Entry	Reviewed	Entry Name	Protein names	Gene Names	Organism	Length	Function [CC]	Miscellaneous [CC]	Gene Ontology (biological process)	Gene Ontology (cellular component)	Gene Ontology (molecular function)	Gene Ontology (GO)	Subcellular location [CC]
A0A087X1C5	reviewed	CP2D7_HUMAN	Putative cytochrome P450 2D7 (EC 1.14.14.1)	CYP2D7	Homo sapiens (Human)	515	FUNCTION: May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine (PubMed:15051713). However, another study could not confirm it (PubMed:18838503). {ECO:0000269|PubMed:15051713, ECO:0000269|PubMed:18838503}.		arachidonic acid metabolic process [GO:0019369]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]	aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; arachidonic acid metabolic process [GO:0019369]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000305|PubMed:15051713}. Mitochondrion {ECO:0000269|PubMed:18838503}.
A0A0B4J2F0	reviewed	PIOS1_HUMAN	Protein PIGBOS1 (PIGB opposite strand protein 1)	PIGBOS1	Homo sapiens (Human)	54	FUNCTION: Plays a role in regulation of the unfolded protein response triggered by endoplasmic reticulum (ER) stress resulting from the presence of unfolded proteins in the ER lumen. {ECO:0000269|PubMed:31653868}.		regulation of endoplasmic reticulum unfolded protein response [GO:1900101]; response to unfolded protein [GO:0006986]	mitochondrial outer membrane [GO:0005741]		mitochondrial outer membrane [GO:0005741]; regulation of endoplasmic reticulum unfolded protein response [GO:1900101]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:31653868}; Single-pass membrane protein {ECO:0000255}.
A0A0B4J2F2	reviewed	SIK1B_HUMAN	Putative serine/threonine-protein kinase SIK1B (EC 2.7.11.1) (Salt-inducible kinase 1B)	SIK1B	Homo sapiens (Human)	783	FUNCTION: Probable serine/threonine-protein kinase. {ECO:0000250|UniProtKB:P57059}.		intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	
A0A0C5B5G6	reviewed	MOTSC_HUMAN	Mitochondrial-derived peptide MOTS-c (Mitochondrial open reading frame of the 12S rRNA-c)	MT-RNR1	Homo sapiens (Human)	16	FUNCTION: Regulates insulin sensitivity and metabolic homeostasis (PubMed:25738459, PubMed:33468709). Inhibits the folate cycle, thereby reducing de novo purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4-carboxamide (AICAR) and the activation of the metabolic regulator 5'-AMP-activated protein kinase (AMPK) (PubMed:25738459). Protects against age-dependent and diet-induced insulin resistance as well as diet-induced obesity (PubMed:25738459). In response to metabolic stress, translocates to the nucleus where it binds to antioxidant response elements (ARE) present in the promoter regions of a number of genes and plays a role in regulating nuclear gene expression in an NFE2L2-dependent manner and increasing cellular resistance to metabolic stress (PubMed:29983246). Increases mitochondrial respiration and levels of CPT1A and cytokines IL1B, IL6, IL8, IL10 and TNF in senescent cells (PubMed:29886458). Increases activity of the serine/threonine protein kinase complex mTORC2 and reduces activity of the PTEN phosphatase, thus promoting phosphorylation of AKT (PubMed:33554779). This promotes AKT-mediated phosphorylation of transcription factor FOXO1 which reduces FOXO1 activity, leading to reduced levels of MSTN and promotion of skeletal muscle growth (PubMed:33554779). Promotes osteogenic differentiation of bone marrow mesenchymal stem cells via the TGFB/SMAD pathway (PubMed:30468456). Promotes osteoblast proliferation and osteoblast synthesis of type I collagens COL1A1 and COL1A2 via the TGFB/SMAD pathway (PubMed:31081069). {ECO:0000269|PubMed:25738459, ECO:0000269|PubMed:29886458, ECO:0000269|PubMed:29983246, ECO:0000269|PubMed:30468456, ECO:0000269|PubMed:31081069, ECO:0000269|PubMed:33468709, ECO:0000269|PubMed:33554779}.	MISCELLANEOUS: Increases survival and decreases bacterial load in mice infected with methicillin-resistant Staphylococcus aureus (MRSA) (PubMed:29096170). Reduces serum levels of inflammatory cytokines such as TNF and IL6 and increases levels of the anti-inflammatory cytokine IL10 (PubMed:29096170). Enhances the phagocytic and bactericidal ability of macrophages and suppresses MAPK pathways while enhancing activation of STAT3 and AHR (PubMed:29096170). {ECO:0000269|PubMed:29096170}.; MISCELLANEOUS: Protects mice against lipopolysaccharide-induced acute lung injury (PubMed:31931370). Reduces body weight loss and pulmonary edema, inhibits neutrophilic tissue infiltration in lung tissue, reduces inflammatory cytokine levels, increases levels of anti-inflammatory cytokines and superoxide dismutase and down-regulates the expression of chemokine CXCL1/CINC1 and adhesion molecule ICAM1 in lung tissues (PubMed:31931370). {ECO:0000269|PubMed:31931370}.; MISCELLANEOUS: Promotes cold adaptation in mice following acute cold exposure (PubMed:31109005). Prevents acute cold-induced liver lipid deposition and increases brown fat activation and white fat browning upon acute cold exposure (PubMed:31109005). Also increases expression of thermogenic genes in vitro (PubMed:31109005). {ECO:0000269|PubMed:31109005}.; MISCELLANEOUS: In a mouse osteolysis model, rescues bone loss, protects bone mass and alleviates inflammation (PubMed:31369811). Decreases TNFSF11/RANKL expression, increases TNFRSF11B/OPG expression and reduces the number of pro-inflammatory macrophages (PubMed:31369811). {ECO:0000269|PubMed:31369811}.; MISCELLANEOUS: In ovarietomized mice, prevents body weight gain, reduces fat mass and adipocyte size, enhances brown fat function, decreases plasma lipid and hepatic triacylglycerol levels, and prevents insulin resistance. {ECO:0000269|PubMed:30725119}.; MISCELLANEOUS: Reduces weight gain in male mice fed a high-fat diet and enhances glucose clearance (PubMed:33468709). Does not reduce weight gain in females on a high-fat diet (PubMed:33468709). {ECO:0000269|PubMed:33468709}.; MISCELLANEOUS: Improves physical performance in both young and aging mice and enhances skeletal muscle adaptation to metabolic stress in vitro. {ECO:0000269|PubMed:33473109}.; MISCELLANEOUS: Reduces vascular calcification (VC) in a rat VC model (PubMed:31694019). Reverses VC-induced reduction in AMPK phosphorylation and decreases expression of receptors AGTR1 and EDNRB (PubMed:31694019). {ECO:0000269|PubMed:31694019}.	activation of protein kinase activity [GO:0032147]; negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:2001145]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; purine-containing compound biosynthetic process [GO:0072522]; regulation of carbohydrate utilization [GO:0043610]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue growth [GO:0048630]	extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]	extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; activation of protein kinase activity [GO:0032147]; negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:2001145]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; purine-containing compound biosynthetic process [GO:0072522]; regulation of carbohydrate utilization [GO:0043610]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue growth [GO:0048630]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25738459}. Mitochondrion {ECO:0000269|PubMed:29983246}. Nucleus {ECO:0000269|PubMed:29983246, ECO:0000269|PubMed:33473109}. Note=Translocates to the nucleus in response to metabolic stress in an AMPK-dependent manner. {ECO:0000269|PubMed:29983246}.
A0A0K2S4Q6	reviewed	CD3CH_HUMAN	Protein CD300H (CD300 antigen-like family member H)	CD300H	Homo sapiens (Human)	201	FUNCTION: May play an important role in innate immunity by mediating a signal for the production of a neutrophil chemoattractant. {ECO:0000269|PubMed:26221034}.		neutrophil chemotaxis [GO:0030593]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; neutrophil chemotaxis [GO:0030593]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:26221034}.
A0A0U1RRE5	reviewed	NBDY_HUMAN	Negative regulator of P-body association (P-body dissociating protein) (Protein NoBody)	NBDY LINC01420	Homo sapiens (Human)	68	FUNCTION: Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process. {ECO:0000269|PubMed:27918561}.		mRNA processing [GO:0006397]; negative regulation of cytoplasmic mRNA processing body assembly [GO:0010607]; nuclear-transcribed mRNA catabolic process [GO:0000956]	P-body [GO:0000932]		P-body [GO:0000932]; mRNA processing [GO:0006397]; negative regulation of cytoplasmic mRNA processing body assembly [GO:0010607]; nuclear-transcribed mRNA catabolic process [GO:0000956]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:27918561}. Note=Localizes to P-bodies at low concentrations without dissociating them. {ECO:0000269|PubMed:27918561}.
A0A1B0GTW7	reviewed	CIROP_HUMAN	Ciliated left-right organizer metallopeptidase (EC 3.4.24.-) (Leishmanolysin-like peptidase 2)	CIROP LMLN2	Homo sapiens (Human)	788	FUNCTION: Putative metalloproteinase that plays a role in left-right patterning process. {ECO:0000250|UniProtKB:A0A1D5NSK0}.		cell adhesion [GO:0007155]; establishment of left/right asymmetry [GO:0061966]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; membrane [GO:0016020]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]	cytoplasm [GO:0005737]; membrane [GO:0016020]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; cell adhesion [GO:0007155]; establishment of left/right asymmetry [GO:0061966]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
A0AV02	reviewed	S12A8_HUMAN	Solute carrier family 12 member 8 (Cation-chloride cotransporter 9)	SLC12A8 CCC9	Homo sapiens (Human)	714	FUNCTION: Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. {ECO:0000269|PubMed:11863360}.		cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]	membrane [GO:0016020]	potassium:chloride symporter activity [GO:0015379]	membrane [GO:0016020]; potassium:chloride symporter activity [GO:0015379]; cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A0AV96	reviewed	RBM47_HUMAN	RNA-binding protein 47 (RNA-binding motif protein 47)	RBM47	Homo sapiens (Human)	593	FUNCTION: Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing (PubMed:24038582, PubMed:24916387, PubMed:27050523, PubMed:30844405, PubMed:31358901, PubMed:34160127). Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules (PubMed:24038582, PubMed:24916387, PubMed:30844405). Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10 (PubMed:34160127). Also involved in the alternative splicing of several genes including TJP1. Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs (PubMed:31358901, PubMed:27050523). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity). {ECO:0000250|UniProtKB:A0A8M1NHK4, ECO:0000269|PubMed:24038582, ECO:0000269|PubMed:24916387, ECO:0000269|PubMed:27050523, ECO:0000269|PubMed:30844405, ECO:0000269|PubMed:31358901, ECO:0000269|PubMed:34160127}.		3'-UTR-mediated mRNA stabilization [GO:0070935]; cytidine to uridine editing [GO:0016554]; hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	enzyme binding [GO:0019899]; enzyme-substrate adaptor activity [GO:0140767]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; enzyme-substrate adaptor activity [GO:0140767]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cytidine to uridine editing [GO:0016554]; hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24038582, ECO:0000269|PubMed:24916387}. Cytoplasm {ECO:0000269|PubMed:24916387}.
A0AVF1	reviewed	IFT56_HUMAN	Intraflagellar transport protein 56 (Tetratricopeptide repeat protein 26) (TPR repeat protein 26)	IFT56 TTC26	Homo sapiens (Human)	554	FUNCTION: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme. {ECO:0000269|PubMed:31595528}.		axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium assembly [GO:0035735]; manchette assembly [GO:1905198]; protein localization to cilium [GO:0061512]; protein transport [GO:0015031]; smoothened signaling pathway [GO:0007224]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]; neuron projection [GO:0043005]	intraciliary transport particle B binding [GO:0120170]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]; neuron projection [GO:0043005]; intraciliary transport particle B binding [GO:0120170]; axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium assembly [GO:0035735]; manchette assembly [GO:1905198]; protein localization to cilium [GO:0061512]; protein transport [GO:0015031]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q8BS45}. Note=Localizes at the base to the ciliary transition zone. {ECO:0000250|UniProtKB:Q8BS45}.
A0AVI4	reviewed	TM129_HUMAN	E3 ubiquitin-protein ligase TM129 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TM129)	TMEM129	Homo sapiens (Human)	362	FUNCTION: E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation. {ECO:0000269|PubMed:24807418}.		protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24807418}; Multi-pass membrane protein {ECO:0000269|PubMed:24807418}.
A0AVK6	reviewed	E2F8_HUMAN	Transcription factor E2F8 (E2F-8)	E2F8	Homo sapiens (Human)	867	FUNCTION: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. {ECO:0000269|PubMed:15897886, ECO:0000269|PubMed:16179649, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:22903062}.		cell cycle comprising mitosis without cytokinesis [GO:0033301]; chorionic trophoblast cell differentiation [GO:0060718]; fibroblast proliferation [GO:0048144]; hepatocyte differentiation [GO:0070365]; negative regulation of cytokinesis [GO:0032466]; negative regulation of transcription by RNA polymerase II [GO:0000122]; placenta development [GO:0001890]; positive regulation of DNA endoreduplication [GO:0032877]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sprouting angiogenesis [GO:0002040]; trophoblast giant cell differentiation [GO:0060707]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell cycle comprising mitosis without cytokinesis [GO:0033301]; chorionic trophoblast cell differentiation [GO:0060718]; fibroblast proliferation [GO:0048144]; hepatocyte differentiation [GO:0070365]; negative regulation of cytokinesis [GO:0032466]; negative regulation of transcription by RNA polymerase II [GO:0000122]; placenta development [GO:0001890]; positive regulation of DNA endoreduplication [GO:0032877]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sprouting angiogenesis [GO:0002040]; trophoblast giant cell differentiation [GO:0060707]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15897886}.
A0AVT1	reviewed	UBA6_HUMAN	Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)	UBA6 MOP4 UBE1L2	Homo sapiens (Human)	1052	FUNCTION: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673}.		amygdala development [GO:0021764]; dendritic spine development [GO:0060996]; hippocampus development [GO:0021766]; learning [GO:0007612]; locomotory behavior [GO:0007626]; protein modification by small protein conjugation [GO:0032446]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; FAT10 activating enzyme activity [GO:0019780]; nucleotidyltransferase activity [GO:0016779]; thiosulfate sulfurtransferase activity [GO:0004792]; ubiquitin activating enzyme activity [GO:0004839]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; FAT10 activating enzyme activity [GO:0019780]; nucleotidyltransferase activity [GO:0016779]; thiosulfate sulfurtransferase activity [GO:0004792]; ubiquitin activating enzyme activity [GO:0004839]; amygdala development [GO:0021764]; dendritic spine development [GO:0060996]; hippocampus development [GO:0021766]; learning [GO:0007612]; locomotory behavior [GO:0007626]; protein modification by small protein conjugation [GO:0032446]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	
A0FGR8	reviewed	ESYT2_HUMAN	Extended synaptotagmin-2 (E-Syt2) (Chr2Syt)	ESYT2 FAM62B KIAA1228	Homo sapiens (Human)	921	FUNCTION: Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}.		endocytosis [GO:0006897]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; membrane [GO:0016020]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; membrane [GO:0016020]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091]; endocytosis [GO:0006897]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:29469807}; Peripheral membrane protein {ECO:0000269|PubMed:17360437}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:29469807}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461, PubMed:27044890). Recruited to the cell membrane via the third C2 domain (PubMed:17360437). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:29469807, ECO:0000269|PubMed:30220461}.
A0FGR9	reviewed	ESYT3_HUMAN	Extended synaptotagmin-3 (E-Syt3) (Chr3Syt)	ESYT3 FAM62C	Homo sapiens (Human)	886	FUNCTION: Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. {ECO:0000250, ECO:0000269|PubMed:23791178}.		endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869]	cytoplasmic side of plasma membrane [GO:0009898]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091]	cytoplasmic side of plasma membrane [GO:0009898]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:29469807}; Peripheral membrane protein {ECO:0000269|PubMed:17360437}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:29469807}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:30220461). Recruited to the cell membrane via the third C2 domain. {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:29469807, ECO:0000269|PubMed:30220461}.
A0JLT2	reviewed	MED19_HUMAN	Mediator of RNA polymerase II transcription subunit 19 (Lung cancer metastasis-related protein 1) (Mediator complex subunit 19)	MED19 LCMR1	Homo sapiens (Human)	244	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.		positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleus [GO:0005634]	transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleus [GO:0005634]; transcription coregulator activity [GO:0003712]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A0JNW5	reviewed	BLT3B_HUMAN	Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like)	BLTP3B KIAA0701 SHIP164 UHRF1BP1L	Homo sapiens (Human)	1464	FUNCTION: Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:35499567, PubMed:20163565). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}.		early endosome to Golgi transport [GO:0034498]; intermembrane lipid transfer [GO:0120009]	cytosol [GO:0005829]; early endosome [GO:0005769]	GARP complex binding [GO:0062069]; lipid transfer activity [GO:0120013]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; early endosome [GO:0005769]; GARP complex binding [GO:0062069]; lipid transfer activity [GO:0120013]; protein homodimerization activity [GO:0042803]; early endosome to Golgi transport [GO:0034498]; intermembrane lipid transfer [GO:0120009]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20163565}. Early endosome {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. Note=Localizes on a subpopulation of vesicle clusters in the early endocytic pathway. {ECO:0000269|PubMed:35499567}.
A0JP26	reviewed	POTB3_HUMAN	POTE ankyrin domain family member B3	POTEB3	Homo sapiens (Human)	581							
A0M8Q6	reviewed	IGLC7_HUMAN	Immunoglobulin lambda constant 7 (Ig lambda-7 chain C region)	IGLC7	Homo sapiens (Human)	106	FUNCTION: Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.	MISCELLANEOUS: Displays the following serological isotype: Ke+, Oz- and two of the three characteristic amino acids of Mgc-isotype: Ala-6 and Ser-8 but instead of Thr-57 it displays Lys-57. Ke+ has Gly-46 and Oz- has Arg-83. {ECO:0000303|Ref.7}.	adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgD immunoglobulin complex [GO:0071738]; IgE immunoglobulin complex [GO:0071742]; IgG immunoglobulin complex [GO:0071735]; IgM immunoglobulin complex [GO:0071753]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgD immunoglobulin complex [GO:0071738]; IgE immunoglobulin complex [GO:0071742]; IgG immunoglobulin complex [GO:0071735]; IgM immunoglobulin complex [GO:0071753]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0MZ66	reviewed	SHOT1_HUMAN	Shootin-1 (Shootin1)	SHTN1 KIAA1598	Homo sapiens (Human)	631	FUNCTION: Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}.		actin filament bundle retrograde transport [GO:0061573]; axonogenesis [GO:0007409]; Cdc42 protein signal transduction [GO:0032488]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; endoplasmic reticulum polarization [GO:0061163]; netrin-activated signaling pathway [GO:0038007]; neuron projection morphogenesis [GO:0048812]; positive regulation of axon extension [GO:0045773]; positive regulation of neuron migration [GO:2001224]; Ras protein signal transduction [GO:0007265]; regulation of establishment of cell polarity [GO:2000114]; substrate-dependent cell migration, cell extension [GO:0006930]	axon [GO:0030424]; axonal growth cone [GO:0044295]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]	axon [GO:0030424]; axonal growth cone [GO:0044295]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; actin filament bundle retrograde transport [GO:0061573]; axonogenesis [GO:0007409]; Cdc42 protein signal transduction [GO:0032488]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; endoplasmic reticulum polarization [GO:0061163]; netrin-activated signaling pathway [GO:0038007]; neuron projection morphogenesis [GO:0048812]; positive regulation of axon extension [GO:0045773]; positive regulation of neuron migration [GO:2001224]; Ras protein signal transduction [GO:0007265]; regulation of establishment of cell polarity [GO:2000114]; substrate-dependent cell migration, cell extension [GO:0006930]	SUBCELLULAR LOCATION: Perikaryon {ECO:0000250|UniProtKB:Q8K2Q9}. Cell projection, axon {ECO:0000250|UniProtKB:Q8K2Q9}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q8K2Q9}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8K2Q9}. Cell projection, filopodium {ECO:0000250|UniProtKB:A0MZ67}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:A0MZ67}. Note=Localizes in multiple growth cones at neurite tips before the neuronal symmetry-breaking step. Accumulates in growth cones of a single nascent axon in a neurite length-dependent manner during the neuronal symmetry-breaking step; when absent from the nascent axon's siblings, probably due to competitive transport, prevents the formation of surplus axons. Transported anterogradely from the soma to the axon growth cone in an actin and myosin-dependent manner and passively diffuses back to the cell bodies. Colocalized with L1CAM in close apposition with actin filaments in filopodia and lamellipodia of axonal growth cones in hippocampal neurons. Exhibits retrograde movements in filopodia and lamellopodia of axonal growth cones. Colocalized with KIF20B along microtubules to the tip of the growing cone in primary hippocampal neurons. Recruited to the growth cone of developing axon in a KIF20B- and microtubule-dependent manner. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}.
A0PJK1	reviewed	SC5AA_HUMAN	Sodium/mannose cotransporter SLC5A10 (Sodium/glucose cotransporter 5) (Na(+)/glucose cotransporter 5) (Solute carrier family 5 member 10)	SLC5A10 SGLT5	Homo sapiens (Human)	596	FUNCTION: [Isoform 1]: Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2 (PubMed:24573086, PubMed:22212718, PubMed:23451068). Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney (PubMed:22212718, PubMed:23451068). {ECO:0000269|PubMed:22212718, ECO:0000269|PubMed:23451068, ECO:0000269|PubMed:24573086}.; FUNCTION: [Isoform 2]: Appears to have no transporter activity. {ECO:0000269|PubMed:22212718}.		hexose transmembrane transport [GO:0008645]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	fructose:sodium symporter activity [GO:0140930]; glucose:sodium symporter activity [GO:0005412]; mannose:sodium symporter activity [GO:0140929]; solute:sodium symporter activity [GO:0015370]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; fructose:sodium symporter activity [GO:0140930]; glucose:sodium symporter activity [GO:0005412]; mannose:sodium symporter activity [GO:0140929]; solute:sodium symporter activity [GO:0015370]; hexose transmembrane transport [GO:0008645]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q5SWY8}; Multi-pass membrane protein {ECO:0000255}.
A0PJY2	reviewed	FEZF1_HUMAN	Fez family zinc finger protein 1 (Zinc finger protein 312B)	FEZF1 FEZ ZNF312B	Homo sapiens (Human)	475	FUNCTION: Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity). {ECO:0000250}.	MISCELLANEOUS: Triggers oncogenic activity specifically in gastric tumors through activation of KRAS in the ERK signaling pathway.	axon guidance [GO:0007411]; cell dedifferentiation [GO:0043697]; forebrain anterior/posterior pattern specification [GO:0021797]; interneuron migration [GO:1904936]; negative regulation of cell population proliferation [GO:0008285]; olfactory bulb development [GO:0021772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; axon guidance [GO:0007411]; cell dedifferentiation [GO:0043697]; forebrain anterior/posterior pattern specification [GO:0021797]; interneuron migration [GO:1904936]; negative regulation of cell population proliferation [GO:0008285]; olfactory bulb development [GO:0021772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19318583}.
A0PK00	reviewed	T120B_HUMAN	Transmembrane protein 120B	TMEM120B	Homo sapiens (Human)	339	FUNCTION: Necessary for efficient adipogenesis. Does not show ion channel activity. {ECO:0000250|UniProtKB:Q3TA38}.		fat cell differentiation [GO:0045444]; protein heterooligomerization [GO:0051291]	nuclear inner membrane [GO:0005637]		nuclear inner membrane [GO:0005637]; fat cell differentiation [GO:0045444]; protein heterooligomerization [GO:0051291]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:Q3TA38}; Multi-pass membrane protein {ECO:0000255}.
A0PK11	reviewed	CLRN2_HUMAN	Clarin-2	CLRN2	Homo sapiens (Human)	232	FUNCTION: Plays a key role to hearing function. Required for normal organization and maintenance of the stereocilia bundle and for mechano-electrical transduction. {ECO:0000250|UniProtKB:B2RVW2}.		auditory receptor cell stereocilium organization [GO:0060088]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045]	stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]		stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; auditory receptor cell stereocilium organization [GO:0060088]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045]	SUBCELLULAR LOCATION: Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:B2RVW2}; Multi-pass membrane protein {ECO:0000255}.
A1A4S6	reviewed	RHG10_HUMAN	Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)	ARHGAP10 GRAF2	Homo sapiens (Human)	786	FUNCTION: GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433). {ECO:0000250|UniProtKB:Q6Y5D8, ECO:0000269|PubMed:11432776, ECO:0000269|PubMed:32344433}.		cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}. Endosome membrane {ECO:0000269|PubMed:32344433}. Note=Association to cell membrane is dependent on PH domain. Colocalized with MICAL1, RAB8A, RAB8B and RAB10 on endosomal tubules (PubMed:32344433). {ECO:0000250, ECO:0000269|PubMed:32344433}.
A1A4Y4	reviewed	IRGM_HUMAN	Immunity-related GTPase family M protein (EC 3.6.5.-) (Immunity-related GTPase family M protein 1) (Interferon-inducible protein 1) (LPS-stimulated RAW 264.7 macrophage protein 47 homolog) (LRG-47)	IRGM IFI1 IRGM1 LRG47	Homo sapiens (Human)	181	FUNCTION: Immunity-related GTPase that plays important roles in innate immunity and inflammatory response (PubMed:16888103, PubMed:19165925, PubMed:25891078). Acts as a dynamin-like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (By similarity). Required for clearance of acute protozoan and bacterial infections by interacting with autophagy and lysosome regulatory proteins, thereby promoting the fusion of phagosomes with lysosomes for efficient degradation of cargo including microbes (PubMed:16888103, PubMed:25891078, PubMed:29420192, PubMed:32939830). Regulates selective autophagy, including xenophagy and mitophagy, both directly and indirectly (PubMed:16888103, PubMed:25891078, PubMed:29420192, PubMed:32939830). Directly regulates autophagy by acting as a molecular adapter that promotes the coassembly of the core autophagy machinery to mediate antimicrobial defense: IRGM (1) activates AMPK, which in turn phosphorylates ULK1 and BECN1 to induce autophagy, (2) promotes the coassembly of ULK1 and BECN1, enhancing BECN1-interacting partners and (3) influences the composition of the BECN1 complex, by competing with the negative regulators BCL2 and RUBCN, to trigger autophagy (PubMed:25891078). Also activates autophagy by promoting recruitment of STX17 to autophagosomes (PubMed:29420192). In collaboration with ATG8 proteins, regulate lysosomal biogenesis, a fundamental process for any autophagic pathway, by promoting TFEB dephosphorylation (PubMed:32753672). Also modulates autophagy by assisting with autophagosome formation and preventing lysosomal deacidification (By similarity). While activating autophagy, acts as a key negative regulator of the inflammatory and interferon responses both by (1) promoting mitophagy and (2) mediating autophagy-dependent degradation of effectors of the inflammatory response (PubMed:30612879, PubMed:32715615, PubMed:36221902). Promotes degradation of damaged and IFNG/IFN-gamma-stressed mitochondria via mitophagy, preventing cytosolic release of ligands that activate inflammation (PubMed:32715615). Acts as a suppressor of inflammation by promoting recruitment of inflammation effectors, such as CGAS, RIGI/RIG-I and NLRP3, to autophagosome membranes, leading to their SQSTM1/p62-dependent autophagic degradation (PubMed:30612879, PubMed:32715615). Also directly inhibits assembly of the NLRP3 inflammasome by preventing the association between NLRP3 and PYCARD (PubMed:30612879). Acts as a negative regulator of antiviral innate immune response by suppressing the RIPK2-dependent pro-inflammatory response: mediates recruitment of RIPosomes, composed of RIPK2 and NOD1 or NOD2, to autophagosome membranes, promoting their SQSTM1/p62-dependent autophagic degradation (PubMed:34467632, PubMed:36221902). {ECO:0000250|UniProtKB:Q60766, ECO:0000269|PubMed:16888103, ECO:0000269|PubMed:19165925, ECO:0000269|PubMed:25891078, ECO:0000269|PubMed:29420192, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:32715615, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:32939830, ECO:0000269|PubMed:34467632, ECO:0000269|PubMed:36221902}.; FUNCTION: [Isoform IRGMd]: Acts as a positive regulator of mitophagy in response to intracellular mycobacteria infection: specifically binds cardiolipin, leading to its translocation to mitochondria, where it promotes affected mitochondrial fission and mitophagy. {ECO:0000269|PubMed:21102437}.; FUNCTION: (Microbial infection) Following infection by hepatitis C virus (HCV), promotes HCV-triggered membrane remodeling, leading to autophagy and Golgi fragmentation, a step required for HCV replication. {ECO:0000269|PubMed:28389568}.	MISCELLANEOUS: There is a huge difference in terms of sequence and regulation of expression compared to the mouse ortholog and hence, the function might be slightly different. {ECO:0000305|PubMed:16277747}.	autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; CAMKK-AMPK signaling cascade [GO:0061762]; cellular response to interferon-beta [GO:0035458]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of defense response to virus [GO:0050687]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of type I interferon production [GO:0032480]; negative regulation of type II interferon production [GO:0032689]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of autophagosome maturation [GO:1901098]; positive regulation of autophagy [GO:0010508]; positive regulation of lysosome organization [GO:1905673]; positive regulation of macrophage activation [GO:0043032]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitophagy [GO:1901526]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; positive regulation of xenophagy [GO:1904417]; protein destabilization [GO:0031648]; protein lipidation involved in autophagosome assembly [GO:0061739]; protein stabilization [GO:0050821]; protein targeting to vacuole involved in autophagy [GO:0071211]; protein-containing complex assembly [GO:0065003]; regulation of protein complex stability [GO:0061635]; regulation of protein-containing complex assembly [GO:0043254]; selective autophagy [GO:0061912]	autophagosome membrane [GO:0000421]; cell projection [GO:0042995]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]	BH3 domain binding [GO:0051434]; CARD domain binding [GO:0050700]; cardiolipin binding [GO:1901612]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; protein-macromolecule adaptor activity [GO:0030674]	autophagosome membrane [GO:0000421]; cell projection [GO:0042995]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; BH3 domain binding [GO:0051434]; CARD domain binding [GO:0050700]; cardiolipin binding [GO:1901612]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; protein-macromolecule adaptor activity [GO:0030674]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; CAMKK-AMPK signaling cascade [GO:0061762]; cellular response to interferon-beta [GO:0035458]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of defense response to virus [GO:0050687]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of type I interferon production [GO:0032480]; negative regulation of type II interferon production [GO:0032689]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of autophagosome maturation [GO:1901098]; positive regulation of autophagy [GO:0010508]; positive regulation of lysosome organization [GO:1905673]; positive regulation of macrophage activation [GO:0043032]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitophagy [GO:1901526]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; positive regulation of xenophagy [GO:1904417]; protein destabilization [GO:0031648]; protein lipidation involved in autophagosome assembly [GO:0061739]; protein stabilization [GO:0050821]; protein targeting to vacuole involved in autophagy [GO:0071211]; protein-containing complex assembly [GO:0065003]; regulation of protein complex stability [GO:0061635]; regulation of protein-containing complex assembly [GO:0043254]; selective autophagy [GO:0061912]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:28389568}. Cell membrane {ECO:0000250|UniProtKB:Q60766}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q60766}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:29420192}. Lysosome membrane {ECO:0000250|UniProtKB:Q60766}. Late endosome membrane {ECO:0000250|UniProtKB:Q60766}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q60766}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q60766}. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing phagosomes. Association with phagosomes is dependent on nucleotide-binding but is IFNG-independent. Also detected in late endosomes and lysosomes. {ECO:0000250|UniProtKB:Q60766}.; SUBCELLULAR LOCATION: [Isoform IRGMd]: Mitochondrion {ECO:0000269|PubMed:21102437}.
A1A519	reviewed	F170A_HUMAN	Protein FAM170A (Zinc finger domain-containing protein) (Zinc finger protein ZNFD)	FAM170A ZNFD	Homo sapiens (Human)	330	FUNCTION: Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE). {ECO:0000269|PubMed:20162441}.		fertilization [GO:0009566]; positive regulation of DNA-templated transcription [GO:0045893]; transcription by RNA polymerase II [GO:0006366]	nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; fertilization [GO:0009566]; positive regulation of DNA-templated transcription [GO:0045893]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20162441}.
A1A5B4	reviewed	ANO9_HUMAN	Anoctamin-9 (Transmembrane protein 16J) (Tumor protein p53-inducible protein 5) (p53-induced gene 5 protein)	ANO9 PIG5 TMEM16J TP53I5	Homo sapiens (Human)	782	FUNCTION: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22178883). Can inhibit the activity of ANO1 (PubMed:20056604, PubMed:22946059). {ECO:0000250|UniProtKB:P86044, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059}.	MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.	calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; establishment of localization in cell [GO:0051649]; lipid metabolic process [GO:0006629]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of intracellular calcium activated chloride channel activity [GO:1902939]	plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; phospholipid scramblase activity [GO:0017128]	plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; phospholipid scramblase activity [GO:0017128]; calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; establishment of localization in cell [GO:0051649]; lipid metabolic process [GO:0006629]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of intracellular calcium activated chloride channel activity [GO:1902939]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
A1A5C7	reviewed	S22AN_HUMAN	Solute carrier family 22 member 23	SLC22A23 C6orf85	Homo sapiens (Human)	686			monoatomic ion transport [GO:0006811]	plasma membrane [GO:0005886]	transmembrane transporter activity [GO:0022857]	plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; monoatomic ion transport [GO:0006811]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A1E959	reviewed	ODAM_HUMAN	Odontogenic ameloblast-associated protein (Apin)	ODAM APIN	Homo sapiens (Human)	279	FUNCTION: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. {ECO:0000269|PubMed:25911094}.	MISCELLANEOUS: ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and, notably, amyloid deposits.	biomineral tissue development [GO:0031214]; inflammatory response [GO:0006954]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein phosphorylation [GO:0001934]; regulation of actin cytoskeleton organization [GO:0032956]	cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; supramolecular fiber [GO:0099512]		cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; supramolecular fiber [GO:0099512]; biomineral tissue development [GO:0031214]; inflammatory response [GO:0006954]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein phosphorylation [GO:0001934]; regulation of actin cytoskeleton organization [GO:0032956]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q3HS83}. Cytoplasm {ECO:0000269|PubMed:25911094}. Nucleus {ECO:0000269|PubMed:25911094}.
A1KXE4	reviewed	F168B_HUMAN	Myelin-associated neurite-outgrowth inhibitor (Mani) (p20)	FAM168B KIAA0280L MANI	Homo sapiens (Human)	195	FUNCTION: Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. {ECO:0000250|UniProtKB:D4AEP3}.			axon [GO:0030424]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]		axon [GO:0030424]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:D4AEP3}. Cell membrane {ECO:0000250|UniProtKB:Q80XQ8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80XQ8}. Cell projection, axon {ECO:0000250|UniProtKB:Q80XQ8}. Note=Expressed in neuronal cell bodies and axonal fibers. {ECO:0000250|UniProtKB:Q80XQ8}.
A1KZ92	reviewed	PXDNL_HUMAN	Probable oxidoreductase PXDNL (EC 1.-.-.-) (Cardiac peroxidase) (Inactive peroxidasin-like protein) (Polysomal ribonuclease 1) (PRM1) (Vascular peroxidase 2)	PXDNL VPO2	Homo sapiens (Human)	1463	FUNCTION: Probable oxidoreductase (Probable). Lacks peroxidase activity (PubMed:24253521). Inhibits the peroxidase activity of PXDN through its interaction (PubMed:24253521). {ECO:0000269|PubMed:24253521, ECO:0000305|PubMed:24253521}.; FUNCTION: [Isoform PMR1]: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs. {ECO:0000269|PubMed:22543864}.		hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	endonuclease activity [GO:0004519]; heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; endonuclease activity [GO:0004519]; heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24253521}. Endoplasmic reticulum {ECO:0000269|PubMed:24253521}. Cell membrane {ECO:0000269|PubMed:24253521}.; SUBCELLULAR LOCATION: [Isoform PMR1]: Cytoplasm. Note=Associates with polysomes.
A1L0T0	reviewed	HACL2_HUMAN	2-hydroxyacyl-CoA lyase 2 (EC 4.1.2.-) (Acetolactate synthase-like protein) (IlvB-like protein)	ILVBL AHAS HACL2	Homo sapiens (Human)	632	FUNCTION: Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. {ECO:0000269|PubMed:28289220}.		fatty acid alpha-oxidation [GO:0001561]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099]	acetolactate synthase complex [GO:0005948]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	acetolactate synthase activity [GO:0003984]; flavin adenine dinucleotide binding [GO:0050660]; lyase activity [GO:0016829]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976]	acetolactate synthase complex [GO:0005948]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; acetolactate synthase activity [GO:0003984]; flavin adenine dinucleotide binding [GO:0050660]; lyase activity [GO:0016829]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976]; fatty acid alpha-oxidation [GO:0001561]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28289220}; Single-pass membrane protein {ECO:0000255}.
A1L167	reviewed	U2QL1_HUMAN	Ubiquitin-conjugating enzyme E2Q-like protein 1 (EC 2.3.2.23) (E2Q-like ubiquitin-conjugating enzyme 1)	UBE2QL1	Homo sapiens (Human)	161	FUNCTION: Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7. {ECO:0000269|PubMed:24000165}.		protein ubiquitination [GO:0016567]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24000165}.
A1L190	reviewed	SYCE3_HUMAN	Synaptonemal complex central element protein 3 (Testis highly expressed gene 2 protein) (THEG-2)	SYCE3 C22orf41 THEG2	Homo sapiens (Human)	88	FUNCTION: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. {ECO:0000250|UniProtKB:B5KM66}.		apoptotic process [GO:0006915]; cell division [GO:0051301]; ectopic germ cell programmed cell death [GO:0035234]; positive regulation of apoptotic process [GO:0043065]; positive regulation of developmental process [GO:0051094]; positive regulation of reproductive process [GO:2000243]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	central element [GO:0000801]; chromosome [GO:0005694]; nucleus [GO:0005634]		central element [GO:0000801]; chromosome [GO:0005694]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; cell division [GO:0051301]; ectopic germ cell programmed cell death [GO:0035234]; positive regulation of apoptotic process [GO:0043065]; positive regulation of developmental process [GO:0051094]; positive regulation of reproductive process [GO:2000243]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B5KM66}. Chromosome {ECO:0000250|UniProtKB:B5KM66}. Note=Colocalizes with SYCE1 in the central elements. {ECO:0000250|UniProtKB:B5KM66}.
A1L390	reviewed	PKHG3_HUMAN	Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3)	PLEKHG3 KIAA0599	Homo sapiens (Human)	1219	FUNCTION: Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}.		regulation of cell migration [GO:0030334]; regulation of establishment of cell polarity [GO:2000114]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]	actin binding [GO:0003779]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; actin binding [GO:0003779]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; regulation of cell migration [GO:0030334]; regulation of establishment of cell polarity [GO:2000114]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:27555588}. Note=Colocalizes with actin at the leading edge of polarized cells. {ECO:0000269|PubMed:27555588}.
A1L3X0	reviewed	ELOV7_HUMAN	Elongation of very long chain fatty acids protein 7 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL7) (ELOVL fatty acid elongase 7) (ELOVL FA elongase 7) (Very long chain 3-ketoacyl-CoA synthase 7) (Very long chain 3-oxoacyl-CoA synthase 7)	ELOVL7	Homo sapiens (Human)	281	FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03207, ECO:0000269|PubMed:19826053, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:21959040, ECO:0000269|PubMed:34117479}.		fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	fatty acid elongase activity [GO:0009922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fatty acid elongase activity [GO:0009922]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03207, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03207}.
A1L4H1	reviewed	SRCRL_HUMAN	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Soluble scavenger protein with 5 SRCR domains) (SSc5D)	SSC5D	Homo sapiens (Human)	1573	FUNCTION: Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity). {ECO:0000250}.		defense response [GO:0006952]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterial lipoprotein [GO:0042494]; innate immune response [GO:0045087]; negative regulation of interleukin-8 production [GO:0032717]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]	extracellular matrix binding [GO:0050840]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; scavenger receptor activity [GO:0005044]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; extracellular matrix binding [GO:0050840]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; scavenger receptor activity [GO:0005044]; defense response [GO:0006952]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterial lipoprotein [GO:0042494]; innate immune response [GO:0045087]; negative regulation of interleukin-8 production [GO:0032717]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}.
A1L4K1	reviewed	FSD2_HUMAN	Fibronectin type III and SPRY domain-containing protein 2 (SPRY domain-containing protein 1)	FSD2 SPRYD1	Homo sapiens (Human)	749				nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum [GO:0016529]		nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum [GO:0016529]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:H0UZ81}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:H0UZ81}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:H0UZ81}. Note=In skeletal muscles and striated muscles flanks Z-disks. Partially colocalizes with RYR2 in the sarcoplasmic reticulum. {ECO:0000250|UniProtKB:H0UZ81}.
A1X283	reviewed	SPD2B_HUMAN	SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)	SH3PXD2B FAD49 KIAA1295 TKS4	Homo sapiens (Human)	911	FUNCTION: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}.		adipose tissue development [GO:0060612]; bone development [GO:0060348]; cell differentiation [GO:0030154]; extracellular matrix disassembly [GO:0022617]; eye development [GO:0001654]; heart development [GO:0007507]; podosome assembly [GO:0071800]; protein localization to membrane [GO:0072657]; skeletal system development [GO:0001501]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; podosome [GO:0002102]	phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-5-phosphate binding [GO:0010314]; SH2 domain binding [GO:0042169]; superoxide-generating NADPH oxidase activator activity [GO:0016176]	anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; podosome [GO:0002102]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-5-phosphate binding [GO:0010314]; SH2 domain binding [GO:0042169]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; adipose tissue development [GO:0060612]; bone development [GO:0060348]; cell differentiation [GO:0030154]; extracellular matrix disassembly [GO:0022617]; eye development [GO:0001654]; heart development [GO:0007507]; podosome assembly [GO:0071800]; protein localization to membrane [GO:0072657]; skeletal system development [GO:0001501]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells. {ECO:0000250}.
A1XBS5	reviewed	CBAR1_HUMAN	CBY1-interacting BAR domain-containing protein 1	CIBAR1 FAM92A FAM92A1	Homo sapiens (Human)	289	FUNCTION: Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis (PubMed:27528616, PubMed:30395363). In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616, PubMed:30395363). Plays an important role in the mitochondrial function and is essential for maintaining mitochondrial morphology and inner membrane ultrastructure (PubMed:30404948). In vitro, can generate membrane curvature through preferential interaction with negatively charged phospholipids such as phosphatidylinositol 4,5-bisphosphate and cardiolipin and hence orchestrate cristae shape (PubMed:30404948). {ECO:0000250|UniProtKB:Q8BP22, ECO:0000269|PubMed:27528616, ECO:0000269|PubMed:30395363, ECO:0000269|PubMed:30404948}.		cilium assembly [GO:0060271]; inner mitochondrial membrane organization [GO:0007007]; limb morphogenesis [GO:0035108]; membrane organization [GO:0061024]; membrane tubulation [GO:0097749]; positive regulation of smoothened signaling pathway [GO:0045880]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	phospholipid binding [GO:0005543]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; phospholipid binding [GO:0005543]; cilium assembly [GO:0060271]; inner mitochondrial membrane organization [GO:0007007]; limb morphogenesis [GO:0035108]; membrane organization [GO:0061024]; membrane tubulation [GO:0097749]; positive regulation of smoothened signaling pathway [GO:0045880]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27528616, ECO:0000269|PubMed:30404948}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:27528616}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27528616, ECO:0000269|PubMed:30395363}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8BP22}. Nucleus {ECO:0000269|PubMed:30404948}. Mitochondrion inner membrane {ECO:0000269|PubMed:30404948}; Peripheral membrane protein {ECO:0000269|PubMed:30404948}; Matrix side {ECO:0000269|PubMed:30404948}. Note=Weak punctate vesicular distribution throughout the cytoplasm (PubMed:27528616). Localizes at the distal end of mother centrioles (PubMed:27528616). Extensive colocalization with CBY1 at mother centrioles (PubMed:27528616). {ECO:0000269|PubMed:27528616}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:17646714}.
A1Z1Q3	reviewed	MACD2_HUMAN	ADP-ribose glycohydrolase MACROD2 (MACRO domain-containing protein 2) (O-acetyl-ADP-ribose deacetylase MACROD2) (EC 3.5.1.-) ([Protein ADP-ribosylaspartate] hydrolase MACROD2) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD2) (EC 3.2.2.-)	MACROD2 C20orf133	Homo sapiens (Human)	425	FUNCTION: Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). {ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712, ECO:0000269|PubMed:23474714}.		brain development [GO:0007420]; DNA damage response [GO:0006974]; peptidyl-glutamate ADP-deribosylation [GO:0140291]; protein de-ADP-ribosylation [GO:0051725]; purine nucleoside metabolic process [GO:0042278]; response to bacterium [GO:0009617]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ADP-ribosylglutamate hydrolase activity [GO:0140293]; deacetylase activity [GO:0019213]; hydrolase activity, acting on glycosyl bonds [GO:0016798]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ADP-ribosylglutamate hydrolase activity [GO:0140293]; deacetylase activity [GO:0019213]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; brain development [GO:0007420]; DNA damage response [GO:0006974]; peptidyl-glutamate ADP-deribosylation [GO:0140291]; protein de-ADP-ribosylation [GO:0051725]; purine nucleoside metabolic process [GO:0042278]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23474712}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. {ECO:0000269|PubMed:23474712}.
A2A288	reviewed	ZC12D_HUMAN	Probable ribonuclease ZC3H12D (EC 3.1.-.-) (MCP-induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain-containing protein 12D) (p34)	ZC3H12D C6orf95 MCPIP4 TFL	Homo sapiens (Human)	527	FUNCTION: May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561). {ECO:0000269|PubMed:17210687, ECO:0000269|PubMed:19531561, ECO:0000269|PubMed:26134560, ECO:0000305}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]	metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:26134560}. Note=Colocalizes with ZC3H12A in GW bodies (GWBs) (PubMed:26134560). {ECO:0000269|PubMed:26134560}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Note=Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.
A2A2Y4	reviewed	FRMD3_HUMAN	FERM domain-containing protein 3 (Band 4.1-like protein 4O) (Ovary type protein 4.1) (4.1O)	FRMD3 EPB41L4O	Homo sapiens (Human)	597	FUNCTION: Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. {ECO:0000269|PubMed:17260017}.		actomyosin structure organization [GO:0031032]	cytoskeleton [GO:0005856]; membrane [GO:0016020]	cytoskeletal protein binding [GO:0008092]	cytoskeleton [GO:0005856]; membrane [GO:0016020]; cytoskeletal protein binding [GO:0008092]; actomyosin structure organization [GO:0031032]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A2IDD5	reviewed	CCD78_HUMAN	Coiled-coil domain-containing protein 78 (hsCCDC78)	CCDC78 C16orf25 JFP10	Homo sapiens (Human)	438	FUNCTION: Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome. {ECO:0000269|PubMed:24075808}.	MISCELLANEOUS: [Isoform 3]: Due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Due to intron retention. {ECO:0000305}.	cell projection organization [GO:0030030]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; skeletal muscle contraction [GO:0003009]	centriole [GO:0005814]; cytoplasm [GO:0005737]; deuterosome [GO:0098536]; perinuclear region of cytoplasm [GO:0048471]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]		centriole [GO:0005814]; cytoplasm [GO:0005737]; deuterosome [GO:0098536]; perinuclear region of cytoplasm [GO:0048471]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; cell projection organization [GO:0030030]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; skeletal muscle contraction [GO:0003009]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, perinuclear region. Cell membrane, sarcolemma. Sarcoplasmic reticulum. Note=Localizes to centrioles and deuterosome. Found primarily in the perinuclear region as well as along the sarcolemmal membrane and in reticular pattern within the sarcoplasm.
A2PYH4	reviewed	HFM1_HUMAN	Probable ATP-dependent DNA helicase HFM1 (EC 3.6.4.12) (SEC63 domain-containing protein 1)	HFM1 SEC3D1	Homo sapiens (Human)	1435	FUNCTION: Required for crossover formation and complete synapsis of homologous chromosomes during meiosis. {ECO:0000250|UniProtKB:D3Z4R1}.		resolution of meiotic recombination intermediates [GO:0000712]	nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; nucleic acid binding [GO:0003676]	nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; nucleic acid binding [GO:0003676]; resolution of meiotic recombination intermediates [GO:0000712]	
A2RRP1	reviewed	NBAS_HUMAN	NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence)	NBAS NAG	Homo sapiens (Human)	2371	FUNCTION: Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Required for normal embryonic development (By similarity). May play a role in the nonsense-mediated decay pathway of mRNAs containing premature stop codons (By similarity). {ECO:0000250|UniProtKB:Q5TYW4, ECO:0000269|PubMed:19369418}.		negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	SNARE binding [GO:0000149]	cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; SNARE binding [GO:0000149]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20577004}. Endoplasmic reticulum {ECO:0000269|PubMed:19369418}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000305}.
A2RTX5	reviewed	SYTC2_HUMAN	Threonine--tRNA ligase 2, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase protein 3)	TARS3 TARSL2	Homo sapiens (Human)	802	FUNCTION: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage. {ECO:0000250|UniProtKB:Q8BLY2}.		threonyl-tRNA aminoacylation [GO:0006435]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; threonine-tRNA ligase activity [GO:0004829]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; threonine-tRNA ligase activity [GO:0004829]; threonyl-tRNA aminoacylation [GO:0006435]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BLY2}. Nucleus {ECO:0000250|UniProtKB:Q8BLY2}. Note=Primarily cytoplasmic. Also detected at lower levels in the nucleus. {ECO:0000250|UniProtKB:Q8BLY2}.
A2RU14	reviewed	TM218_HUMAN	Transmembrane protein 218	TMEM218	Homo sapiens (Human)	115	FUNCTION: May be involved in ciliary biogenesis or function. {ECO:0000250|UniProtKB:Q9CQ44}.			cilium [GO:0005929]; membrane [GO:0016020]		cilium [GO:0005929]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9CQ44}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250|UniProtKB:Q9CQ44}.
A2RU30	reviewed	TESP1_HUMAN	Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1)	TESPA1 KIAA0748 HSPC257	Homo sapiens (Human)	521	FUNCTION: Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269|PubMed:22561606}.		COP9 signalosome assembly [GO:0010387]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein localization [GO:0008104]; T cell differentiation in thymus [GO:0033077]; TCR signalosome assembly [GO:0036399]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; TCR signalosome [GO:0036398]	phospholipase binding [GO:0043274]; signaling receptor binding [GO:0005102]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; TCR signalosome [GO:0036398]; phospholipase binding [GO:0043274]; signaling receptor binding [GO:0005102]; COP9 signalosome assembly [GO:0010387]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein localization [GO:0008104]; T cell differentiation in thymus [GO:0033077]; TCR signalosome assembly [GO:0036399]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22561606, ECO:0000269|PubMed:23501103}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23501103}. Note=May localize to mitochondria-associated endoplasmic reticulum membrane (MAM). {ECO:0000269|PubMed:23501103}.
A2RU49	reviewed	HYKK_HUMAN	Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1)	HYKK AGPHD1	Homo sapiens (Human)	373	FUNCTION: Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine. {ECO:0000269|PubMed:22241472}.		lysine catabolic process [GO:0006554]; phosphorylation [GO:0016310]	mitochondrial matrix [GO:0005759]	amino acid kinase activity [GO:0019202]; hydroxylysine kinase activity [GO:0047992]	mitochondrial matrix [GO:0005759]; amino acid kinase activity [GO:0019202]; hydroxylysine kinase activity [GO:0047992]; lysine catabolic process [GO:0006554]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
A2RUB1	reviewed	MEIOC_HUMAN	Meiosis-specific coiled-coil domain-containing protein MEIOC (Meiosis-specific with coiled-coil domain protein)	MEIOC C17orf104	Homo sapiens (Human)	952	FUNCTION: Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle. {ECO:0000250|UniProtKB:A2AG06}.		chromosome organization involved in meiotic cell cycle [GO:0070192]; double-strand break repair [GO:0006302]; female meiosis I [GO:0007144]; germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; male meiosis I [GO:0007141]; metaphase chromosome alignment [GO:0051310]; mRNA stabilization [GO:0048255]; oocyte development [GO:0048599]; spermatid development [GO:0007286]; synaptonemal complex assembly [GO:0007130]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromosome organization involved in meiotic cell cycle [GO:0070192]; double-strand break repair [GO:0006302]; female meiosis I [GO:0007144]; germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; male meiosis I [GO:0007141]; metaphase chromosome alignment [GO:0051310]; mRNA stabilization [GO:0048255]; oocyte development [GO:0048599]; spermatid development [GO:0007286]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2AG06}. Nucleus {ECO:0000250|UniProtKB:A2AG06}. Note=at late pachytene a fraction is nuclear. {ECO:0000250|UniProtKB:A2AG06}.
A2RUB6	reviewed	CCD66_HUMAN	Coiled-coil domain-containing protein 66	CCDC66	Homo sapiens (Human)	948	FUNCTION: Microtubule-binding protein required for ciliogenesis (PubMed:28235840). May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (PubMed:28235840). Plays a role in retina morphogenesis and/or homeostasis (By similarity). {ECO:0000250|UniProtKB:Q6NS45, ECO:0000269|PubMed:28235840}.		cilium assembly [GO:0060271]; detection of light stimulus involved in visual perception [GO:0050908]; microtubule bundle formation [GO:0001578]; regulation of protein localization to cilium [GO:1903564]; retina homeostasis [GO:0001895]	cell junction [GO:0030054]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; Flemming body [GO:0090543]; microtubule [GO:0005874]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]	cell junction [GO:0030054]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; Flemming body [GO:0090543]; microtubule [GO:0005874]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; cilium assembly [GO:0060271]; detection of light stimulus involved in visual perception [GO:0050908]; microtubule bundle formation [GO:0001578]; regulation of protein localization to cilium [GO:1903564]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28235840}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:28235840}. Cell projection, cilium {ECO:0000269|PubMed:28235840}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28235840}. Photoreceptor inner segment {ECO:0000269|PubMed:19777273}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:19777273}. Note=Restricted to the centrosomes and the spindle microtubules during mitosis (PubMed:28235840). Enriched in the inner segment of the photoreceptor (PubMed:19777273). {ECO:0000269|PubMed:19777273, ECO:0000269|PubMed:28235840}.
A2RUC4	reviewed	TYW5_HUMAN	tRNA wybutosine-synthesizing protein 5 (hTYW5) (tRNA yW-synthesizing protein 5) (EC 1.14.11.42) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase)	TYW5 C2orf60	Homo sapiens (Human)	315	FUNCTION: tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes. {ECO:0000269|PubMed:20739293, ECO:0000269|PubMed:20972222}.		wybutosine biosynthetic process [GO:0031591]	cytoplasm [GO:0005737]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity [GO:0102524]	cytoplasm [GO:0005737]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity [GO:0102524]; wybutosine biosynthetic process [GO:0031591]	
A2RUH7	reviewed	MBPHL_HUMAN	Myosin-binding protein H-like	MYBPHL	Homo sapiens (Human)	354	FUNCTION: Myosin-binding protein which plays a role in cardiac function (PubMed:28778945). Seems to regulate conduction in the atria and ventricular conduction systems (PubMed:28778945). {ECO:0000269|PubMed:28778945}.		in utero embryonic development [GO:0001701]	myofilament [GO:0036379]; sarcomere [GO:0030017]		myofilament [GO:0036379]; sarcomere [GO:0030017]; in utero embryonic development [GO:0001701]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000305|PubMed:28778945}.
A2VDJ0	reviewed	T131L_HUMAN	Transmembrane protein 131-like	TMEM131L KIAA0922	Homo sapiens (Human)	1609	FUNCTION: [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. {ECO:0000269|PubMed:23690469}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23690469}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:23690469}. Note=During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones. {ECO:0000269|PubMed:23690469}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum {ECO:0000269|PubMed:23690469}. Note=Transmembrane localization is essential for Wnt signaling inhibition. {ECO:0000269|PubMed:23690469}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:23690469}. Note=Scattered throughout the cytoplasm in small-sized punctate structures. {ECO:0000269|PubMed:23690469}.
A2VEC9	reviewed	SSPO_HUMAN	SCO-spondin (SCO-spondin pseudogene)	SSPOP KIAA2036 SSPO	Homo sapiens (Human)	5150	FUNCTION: Involved in the modulation of neuronal aggregation (By similarity). May be involved in developmental events during the formation of the central nervous system (By similarity). {ECO:0000250|UniProtKB:P98167}.		cell adhesion [GO:0007155]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane protein complex [GO:0098797]	peptidase inhibitor activity [GO:0030414]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane protein complex [GO:0098797]; peptidase inhibitor activity [GO:0030414]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250|UniProtKB:P98167}.
A3KMH1	reviewed	VWA8_HUMAN	von Willebrand factor A domain-containing protein 8 (PEX7-binding protein 2) (P7BP2)	VWA8 KIAA0564	Homo sapiens (Human)	1905	FUNCTION: Exhibits ATPase activity in vitro. {ECO:0000250|UniProtKB:Q8CC88}.	MISCELLANEOUS: [Isoform 2]: AA 66-79 are essential for peroxisome localization. {ECO:0000269|PubMed:30204880}.		cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:30204880}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000269|PubMed:30204880}. Peroxisome {ECO:0000269|PubMed:30204880}. Note=Localizes to peroxisomes in a PEX7-dependent manner. {ECO:0000269|PubMed:30204880}.
A4D0S4	reviewed	LAMB4_HUMAN	Laminin subunit beta-4 (Laminin beta-1-related protein)	LAMB4	Homo sapiens (Human)	1761	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.		cell adhesion [GO:0007155]	basement membrane [GO:0005604]; extracellular region [GO:0005576]		basement membrane [GO:0005604]; extracellular region [GO:0005576]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
A4D126	reviewed	ISPD_HUMAN	D-ribitol-5-phosphate cytidylyltransferase (EC 2.7.7.40) (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein) (Isoprenoid synthase domain-containing protein) (hISPD)	CRPPA ISPD	Homo sapiens (Human)	451	FUNCTION: Cytidylyltransferase required for protein O-linked mannosylation (PubMed:22522420, PubMed:27130732, PubMed:27601598, PubMed:26687144, PubMed:22522421, PubMed:26923585). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (PubMed:27130732, PubMed:26687144, PubMed:26923585). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:27130732, PubMed:26687144, PubMed:26923585). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (PubMed:26687144). Not Involved in dolichol production (PubMed:26687144). {ECO:0000269|PubMed:22522420, ECO:0000269|PubMed:22522421, ECO:0000269|PubMed:26687144, ECO:0000269|PubMed:26923585, ECO:0000269|PubMed:27130732, ECO:0000269|PubMed:27601598}.		axon guidance [GO:0007411]; isoprenoid biosynthetic process [GO:0008299]; protein O-linked mannosylation [GO:0035269]	cytosol [GO:0005829]	cytidylyltransferase activity [GO:0070567]; D-ribitol-5-phosphate cytidylyltransferase activity [GO:0047349]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; cytidylyltransferase activity [GO:0070567]; D-ribitol-5-phosphate cytidylyltransferase activity [GO:0047349]; protein homodimerization activity [GO:0042803]; axon guidance [GO:0007411]; isoprenoid biosynthetic process [GO:0008299]; protein O-linked mannosylation [GO:0035269]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:26687144}.
A4D161	reviewed	F221A_HUMAN	Protein FAM221A	FAM221A C7orf46	Homo sapiens (Human)	298							
A4D1B5	reviewed	GSAP_HUMAN	Gamma-secretase-activating protein (GSAP) (Protein pigeon homolog) [Cleaved into: Gamma-secretase-activating protein 16 kDa C-terminal form (GSAP-16K)]	GSAP PION	Homo sapiens (Human)	854	FUNCTION: Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. {ECO:0000269|PubMed:20811458}.	MISCELLANEOUS: The gamma-secretase regulator activity is specifically inhibited by imatinib (also known as STI571 or Gleevec), an anticancer drug that selectively decreases amyloid-beta protein production. Imatinib binds PION/GSAP and acts by preventing PION/GSAP interaction with the gamma-secretase substrate, CTF-alpha (PubMed:20811458). {ECO:0000305|PubMed:20811458}.; MISCELLANEOUS: Its role as an activator of amyloid-beta protein production makes it a promising therapeutic target for the treatment of Alzheimer disease. {ECO:0000305|PubMed:20811458}.	positive regulation of amyloid-beta formation [GO:1902004]; regulation of proteolysis [GO:0030162]	trans-Golgi network [GO:0005802]	amyloid-beta binding [GO:0001540]	trans-Golgi network [GO:0005802]; amyloid-beta binding [GO:0001540]; positive regulation of amyloid-beta formation [GO:1902004]; regulation of proteolysis [GO:0030162]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:20811458}.
A4D1E9	reviewed	GTPBA_HUMAN	GTP-binding protein 10 (Protein obg homolog 2) (ObgH2)	GTPBP10 OBGH2 UG0751c10	Homo sapiens (Human)	387	FUNCTION: May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed. {ECO:0000269|PubMed:17054726}.		ribosome biogenesis [GO:0042254]	chromosome [GO:0005694]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723]	chromosome [GO:0005694]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:17054726}. Chromosome {ECO:0000269|PubMed:17054726}. Note=Found in the dense fibrillar compartment region of the nucleolus. At the onset of mitosis moves to the chromosome surface and remains there until anaphase. Gradually re-assembles into the nucleolus at late anaphase to telophase.
A4D1P6	reviewed	WDR91_HUMAN	WD repeat-containing protein 91	WDR91 HSPC049	Homo sapiens (Human)	747	FUNCTION: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity). {ECO:0000250|UniProtKB:Q7TMQ7, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}.		early endosome to late endosome transport [GO:0045022]; regulation of protein catabolic process [GO:0042176]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extrinsic component of endosome membrane [GO:0031313]; late endosome membrane [GO:0031902]	phosphatidylinositol 3-kinase regulator activity [GO:0035014]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extrinsic component of endosome membrane [GO:0031313]; late endosome membrane [GO:0031902]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; early endosome to late endosome transport [GO:0045022]; regulation of protein catabolic process [GO:0042176]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:26783301}; Peripheral membrane protein {ECO:0000269|PubMed:26783301}. Late endosome membrane {ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:28404643}.
A4D1T9	reviewed	PRS37_HUMAN	Probable inactive serine protease 37 (Probable inactive trypsin-X2)	PRSS37 TRYX2	Homo sapiens (Human)	235	FUNCTION: Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system (PubMed:27649891). {ECO:0000250|UniProtKB:Q9DAA4, ECO:0000269|PubMed:27649891}.		binding of sperm to zona pellucida [GO:0007339]; cell migration [GO:0016477]; germ cell migration [GO:0008354]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of fertilization [GO:1905516]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of protein processing [GO:0070613]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; nucleus [GO:0005634]	serine-type endopeptidase activity [GO:0004252]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; nucleus [GO:0005634]; serine-type endopeptidase activity [GO:0004252]; binding of sperm to zona pellucida [GO:0007339]; cell migration [GO:0016477]; germ cell migration [GO:0008354]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of fertilization [GO:1905516]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of protein processing [GO:0070613]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:27649891}. Secreted {ECO:0000305}.
A4D256	reviewed	CC14C_HUMAN	Dual specificity protein phosphatase CDC14C (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog C)	CDC14C CDC14B2 CDC14Bretro	Homo sapiens (Human)	447	FUNCTION: Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity). {ECO:0000250}.	MISCELLANEOUS: May act as an autosomal functional substitute.	cilium assembly [GO:0060271]; dephosphorylation [GO:0016311]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of cytokinesis [GO:0032467]; regulation of exit from mitosis [GO:0007096]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; spindle pole [GO:0000922]	myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; spindle pole [GO:0000922]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cilium assembly [GO:0060271]; dephosphorylation [GO:0016311]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of cytokinesis [GO:0032467]; regulation of exit from mitosis [GO:0007096]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18547142}; Single-pass membrane protein {ECO:0000255}. Note=Retains its endoplasmic reticulum localization during mitosis. {ECO:0000269|PubMed:18547142}.
A4D2B0	reviewed	MBLC1_HUMAN	Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1)	MBLAC1	Homo sapiens (Human)	266	FUNCTION: Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase (PubMed:30507380). Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop (PubMed:30507380). May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage (PubMed:30507380). {ECO:0000269|PubMed:30507380}.		histone mRNA metabolic process [GO:0008334]; mRNA 3'-end processing [GO:0031124]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]; histone mRNA metabolic process [GO:0008334]; mRNA 3'-end processing [GO:0031124]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:30507380}. Nucleus {ECO:0000269|PubMed:30507380}. Note=Localizes in the nucleus during early S-phase of the cell cycle. {ECO:0000269|PubMed:30507380}.
A4D2B8	reviewed	PM2P1_HUMAN	Putative postmeiotic segregation increased 2-like protein 1 (PMS2-related protein 2) (Postmeiotic segregation increased 2-like protein 13) (Postmeiotic segregation increased 2-like protein 6) (Postmeiotic segregation increased 2-like protein 8) (Postmeiotic segregation increased protein 3) (hPMS3) (Postmeiotic segregation increased protein 8) (Putative postmeiotic segregation increased 2 pseudogene 1)	PMS2P1 PMS2L1 PMS2L13 PMS2L6 PMS2L8 PMS3 PMS8 PMSR2	Homo sapiens (Human)	440		MISCELLANEOUS: Encoded by one of the numerous copies of postmeiotic segregation increased 2-like genes scattered in the q11-q22 region of the chromosome 7.	mismatch repair [GO:0006298]; phosphorylation [GO:0016310]	mismatch repair complex [GO:0032300]	ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; kinase activity [GO:0016301]	mismatch repair complex [GO:0032300]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; kinase activity [GO:0016301]; mismatch repair [GO:0006298]; phosphorylation [GO:0016310]	
A4GXA9	reviewed	EME2_HUMAN	Probable crossover junction endonuclease EME2 (EC 3.1.22.-)	EME2	Homo sapiens (Human)	379	FUNCTION: Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. {ECO:0000269|PubMed:17289582}.		double-strand break repair [GO:0006302]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]	endodeoxyribonuclease complex [GO:1905347]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596]	DNA binding [GO:0003677]; endonuclease activity [GO:0004519]	endodeoxyribonuclease complex [GO:1905347]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; double-strand break repair [GO:0006302]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A4UGR9	reviewed	XIRP2_HUMAN	Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin)	XIRP2 CMYA3	Homo sapiens (Human)	3374	FUNCTION: Protects actin filaments from depolymerization. {ECO:0000269|PubMed:15454575}.	MISCELLANEOUS: 'Xin' means 'heart' in Chinese.	actin filament organization [GO:0007015]; cardiac muscle tissue morphogenesis [GO:0055008]; cell-cell junction organization [GO:0045216]; ventricular septum development [GO:0003281]	anchoring junction [GO:0070161]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; alpha-actinin binding [GO:0051393]	anchoring junction [GO:0070161]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; alpha-actinin binding [GO:0051393]; actin filament organization [GO:0007015]; cardiac muscle tissue morphogenesis [GO:0055008]; cell-cell junction organization [GO:0045216]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:15454575}. Note=Colocalizes with actin stress fibers. {ECO:0000250}.
A5A3E0	reviewed	POTEF_HUMAN	POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein)	POTEF A26C1B	Homo sapiens (Human)	1075		MISCELLANEOUS: Results from the insertion of a beta-actin fragment at the C-terminus in the POTEE paralog gene leading to the formation of a new functional chimeric protein. This insertion occured before the divergence of the Old World monkeys and apes.	axonogenesis [GO:0007409]; cell motility [GO:0048870]; retina homeostasis [GO:0001895]	actin filament [GO:0005884]; axon [GO:0030424]; blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202]	protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]	actin filament [GO:0005884]; axon [GO:0030424]; blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202]; protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:17101985}. Note=Colocalizes with actin filaments.
A5D8T8	reviewed	CL18A_HUMAN	C-type lectin domain family 18 member A (Mannose receptor-like protein 2)	CLEC18A MRLP2	Homo sapiens (Human)	446	FUNCTION: Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455). {ECO:0000269|PubMed:26170455}.			endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]	polysaccharide binding [GO:0030247]	endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; polysaccharide binding [GO:0030247]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26170455}. Endoplasmic reticulum {ECO:0000305|PubMed:26170455}. Golgi apparatus {ECO:0000305|PubMed:26170455}. Endosome {ECO:0000305|PubMed:26170455}.
A5D8V6	reviewed	VP37C_HUMAN	Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C)	VPS37C PML39	Homo sapiens (Human)	355	FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15509564}.		macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]	endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]	calcium-dependent protein binding [GO:0048306]	endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; calcium-dependent protein binding [GO:0048306]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000305|PubMed:15509564}; Peripheral membrane protein {ECO:0000305|PubMed:15509564}. Note=Probably associates with membranes. Recruited to the plasma membrane by HIV-1.
A5D8V7	reviewed	ODAD3_HUMAN	Outer dynein arm-docking complex subunit 3 (Coiled-coil domain-containing protein 151)	ODAD3 CCDC151	Homo sapiens (Human)	595	FUNCTION: Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule (PubMed:25192045). Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (PubMed:25192045). {ECO:0000269|PubMed:25192045}.		brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; flagellated sperm motility [GO:0030317]; multicellular organism growth [GO:0035264]; outer dynein arm assembly [GO:0036158]; regulation of cilium assembly [GO:1902017]; spermatogenesis [GO:0007283]	axoneme [GO:0005930]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; ciliary tip [GO:0097542]; cilium [GO:0005929]; extracellular region [GO:0005576]; outer dynein arm docking complex [GO:0120228]		axoneme [GO:0005930]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; ciliary tip [GO:0097542]; cilium [GO:0005929]; extracellular region [GO:0005576]; outer dynein arm docking complex [GO:0120228]; brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; flagellated sperm motility [GO:0030317]; multicellular organism growth [GO:0035264]; outer dynein arm assembly [GO:0036158]; regulation of cilium assembly [GO:1902017]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8BSN3}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8BSN3}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:25192045}.
A5D8W1	reviewed	CFA69_HUMAN	Cilia- and flagella-associated protein 69	CFAP69 C7orf63	Homo sapiens (Human)	941	FUNCTION: Cilium- and flagellum-associated protein (PubMed:29606301). In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability (PubMed:29606301). {ECO:0000250|UniProtKB:Q8BH53, ECO:0000269|PubMed:29606301}.	MISCELLANEOUS: [Isoform 2]: Incomplete sequence. {ECO:0000305}.	flagellated sperm motility [GO:0030317]; olfactory behavior [GO:0042048]; positive regulation of fertilization [GO:1905516]; positive regulation of flagellated sperm motility [GO:1902093]; response to odorant [GO:1990834]; sensory perception of smell [GO:0007608]; sperm axoneme assembly [GO:0007288]	cytoplasm [GO:0005737]; non-motile cilium [GO:0097730]; sperm midpiece [GO:0097225]		cytoplasm [GO:0005737]; non-motile cilium [GO:0097730]; sperm midpiece [GO:0097225]; flagellated sperm motility [GO:0030317]; olfactory behavior [GO:0042048]; positive regulation of fertilization [GO:1905516]; positive regulation of flagellated sperm motility [GO:1902093]; response to odorant [GO:1990834]; sensory perception of smell [GO:0007608]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q8BH53}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:29606301}. Note=Localizes to the midpiece of the sperm flagellum. {ECO:0000269|PubMed:29606301}.
A5LHX3	reviewed	PSB11_HUMAN	Proteasome subunit beta type-11 (EC 3.4.25.1) (Proteasome subunit beta-5t)	PSMB11	Homo sapiens (Human)	300	FUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity). {ECO:0000250}.		CD8-positive, alpha-beta T cell differentiation [GO:0043374]; proteasomal protein catabolic process [GO:0010498]; proteolysis [GO:0006508]; T cell differentiation in thymus [GO:0033077]	cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome core complex, beta-subunit complex [GO:0019774]	endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; threonine-type endopeptidase activity [GO:0004298]	cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome core complex, beta-subunit complex [GO:0019774]; endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; threonine-type endopeptidase activity [GO:0004298]; CD8-positive, alpha-beta T cell differentiation [GO:0043374]; proteasomal protein catabolic process [GO:0010498]; proteolysis [GO:0006508]; T cell differentiation in thymus [GO:0033077]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
A5PKW4	reviewed	PSD1_HUMAN	PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1)	PSD EFA6 EFA6A KIAA2011 PSD1 TYL	Homo sapiens (Human)	1024	FUNCTION: Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity). {ECO:0000250|UniProtKB:Q5DTT2, ECO:0000269|PubMed:23603394}.		neuron projection development [GO:0031175]; regulation of ARF protein signal transduction [GO:0032012]; signal transduction [GO:0007165]	cleavage furrow [GO:0032154]; dendritic spine [GO:0043197]; postsynaptic density, intracellular component [GO:0099092]; ruffle membrane [GO:0032587]	guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543]	cleavage furrow [GO:0032154]; dendritic spine [GO:0043197]; postsynaptic density, intracellular component [GO:0099092]; ruffle membrane [GO:0032587]; guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543]; neuron projection development [GO:0031175]; regulation of ARF protein signal transduction [GO:0032012]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23603394}. Cell projection, ruffle membrane {ECO:0000269|PubMed:23603394}. Cleavage furrow {ECO:0000269|PubMed:23603394}. Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In later cytokinesis phases, fades away from the cleavage furrow and becomes uniformly distributed throughout the plasma membrane. {ECO:0000269|PubMed:23603394}.
A5PLL7	reviewed	PDES1_HUMAN	Plasmanylethanolamine desaturase 1 (EC 1.14.19.77) (Transmembrane protein 189)	PEDS1 KUA PDES TMEM189	Homo sapiens (Human)	270	FUNCTION: Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane (PubMed:31604315, PubMed:32209662, PubMed:33859415). Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms (PubMed:31604315). {ECO:0000269|PubMed:31604315, ECO:0000269|PubMed:32209662, ECO:0000269|PubMed:33859415, ECO:0000303|PubMed:31604315}.	MISCELLANEOUS: In human, PESD1 and UBE2V1 are adjacent genes which can produce independent proteins and can also be fused to form a PESD1-UBE2V1 hybrid protein. {ECO:0000269|PubMed:11076860}.	ether lipid biosynthetic process [GO:0008611]; fatty acid metabolic process [GO:0006631]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	plasmanylethanolamine desaturase activity [GO:0050207]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasmanylethanolamine desaturase activity [GO:0050207]; ether lipid biosynthetic process [GO:0008611]; fatty acid metabolic process [GO:0006631]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11076860, ECO:0000269|PubMed:31604315}; Multi-pass membrane protein {ECO:0000255}.
A5X5Y0	reviewed	5HT3E_HUMAN	5-hydroxytryptamine receptor 3E (5-HT3-E) (5-HT3E) (Serotonin receptor 3E)	HTR3E	Homo sapiens (Human)	456	FUNCTION: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. {ECO:0000269|PubMed:17392525}.		inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; serotonin-gated monoatomic cation-selective channel activity [GO:0022850]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; serotonin-gated monoatomic cation-selective channel activity [GO:0022850]; inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:17392525}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:17392525, ECO:0000269|PubMed:19012743}; Multi-pass membrane protein {ECO:0000255}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. {ECO:0000269|PubMed:17392525}.
A5YKK6	reviewed	CNOT1_HUMAN	CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1)	CNOT1 CDC39 KIAA1007 NOT1 AD-005	Homo sapiens (Human)	2376	FUNCTION: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:10637334, ECO:0000269|PubMed:16778766, ECO:0000269|PubMed:21278420, ECO:0000269|PubMed:21976065, ECO:0000269|PubMed:21984185, ECO:0000269|PubMed:22367759, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:32354837}.		miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of stem cell population maintenance [GO:2000036]; trophectodermal cell differentiation [GO:0001829]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; peroxisomal membrane [GO:0005778]	armadillo repeat domain binding [GO:0070016]; molecular adaptor activity [GO:0060090]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoic acid receptor binding [GO:0042974]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; peroxisomal membrane [GO:0005778]; armadillo repeat domain binding [GO:0070016]; molecular adaptor activity [GO:0060090]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoic acid receptor binding [GO:0042974]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of stem cell population maintenance [GO:2000036]; trophectodermal cell differentiation [GO:0001829]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:21976065}. Nucleus {ECO:0000305|PubMed:21976065}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250|UniProtKB:Q6ZQ08}.
A5YM72	reviewed	CRNS1_HUMAN	Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1)	CARNS1 ATPGD1 KIAA1394	Homo sapiens (Human)	827	FUNCTION: Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. {ECO:0000269|PubMed:20097752}.		carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548]	cytosol [GO:0005829]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; carnosine synthase activity [GO:0047730]; homocarnosine synthase activity [GO:0102102]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; carnosine synthase activity [GO:0047730]; homocarnosine synthase activity [GO:0102102]; metal ion binding [GO:0046872]; carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548]	
A6BM72	reviewed	MEG11_HUMAN	Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11)	MEGF11 KIAA1781 UNQ1949/PRO4432	Homo sapiens (Human)	1044	FUNCTION: May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity). {ECO:0000250}.		homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842]	basolateral plasma membrane [GO:0016323]		basolateral plasma membrane [GO:0016323]; homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17498693}; Single-pass type I membrane protein {ECO:0000269|PubMed:17498693}. Basolateral cell membrane {ECO:0000269|PubMed:17498693}; Single-pass type I membrane protein {ECO:0000269|PubMed:17498693}. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10.
A6H8Y1	reviewed	BDP1_HUMAN	Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator)	BDP1 KIAA1241 KIAA1689 TFNR	Homo sapiens (Human)	2624	FUNCTION: General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}.		RNA polymerase III preinitiation complex assembly [GO:0070898]	nucleoplasm [GO:0005654]; transcription factor TFIIIB complex [GO:0000126]	TFIIIC-class transcription factor complex binding [GO:0001156]	nucleoplasm [GO:0005654]; transcription factor TFIIIB complex [GO:0000126]; TFIIIC-class transcription factor complex binding [GO:0001156]; RNA polymerase III preinitiation complex assembly [GO:0070898]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11161782}.
A6H8Z2	reviewed	F221B_HUMAN	Protein FAM221B	FAM221B C9orf128	Homo sapiens (Human)	402							
A6NC98	reviewed	CC88B_HUMAN	Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3)	CCDC88B BRLZ	Homo sapiens (Human)	1476	FUNCTION: Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}.		cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; defense response to protozoan [GO:0042832]; positive regulation of cytokine production [GO:0001819]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell proliferation [GO:0042102]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	dynein light intermediate chain binding [GO:0051959]; microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; dynein light intermediate chain binding [GO:0051959]; microtubule binding [GO:0008017]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; defense response to protozoan [GO:0042832]; positive regulation of cytokine production [GO:0001819]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell proliferation [GO:0042102]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q4QRL3}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:25762780}. Endoplasmic reticulum {ECO:0000269|PubMed:21289099}. Golgi apparatus {ECO:0000269|PubMed:21289099}. Cytoplasm {ECO:0000269|PubMed:21289099}.
A6NCS4	reviewed	NKX26_HUMAN	Homeobox protein Nkx-2.6 (Homeobox protein NK-2 homolog F)	NKX2-6 NKX2F	Homo sapiens (Human)	301	FUNCTION: Acts as a transcriptional activator (PubMed:15649947). In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. {ECO:0000250|UniProtKB:P43688, ECO:0000269|PubMed:15649947}.		atrial cardiac muscle cell development [GO:0055014]; cell differentiation [GO:0030154]; digestive tract development [GO:0048565]; embryonic heart tube development [GO:0035050]; epithelial cell apoptotic process [GO:1904019]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation [GO:0050673]; hypothalamus development [GO:0021854]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell apoptotic process [GO:1904036]; pericardium development [GO:0060039]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; tongue development [GO:0043586]; ventricular cardiac muscle cell development [GO:0055015]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; atrial cardiac muscle cell development [GO:0055014]; cell differentiation [GO:0030154]; digestive tract development [GO:0048565]; embryonic heart tube development [GO:0035050]; epithelial cell apoptotic process [GO:1904019]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation [GO:0050673]; hypothalamus development [GO:0021854]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell apoptotic process [GO:1904036]; pericardium development [GO:0060039]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; tongue development [GO:0043586]; ventricular cardiac muscle cell development [GO:0055015]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A6ND01	reviewed	JUNO_HUMAN	Sperm-egg fusion protein Juno (Folate receptor 4) (Folate receptor delta) (FR-delta) (IZUMO1 receptor protein JUNO)	IZUMO1R FOLR4 JUNO	Homo sapiens (Human)	250	FUNCTION: Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. {ECO:0000250|UniProtKB:Q9EQF4}.	MISCELLANEOUS: [Isoform 2]: Gene prediction based on similarity to orthologs. {ECO:0000305}.	cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; single fertilization [GO:0007338]; sperm-egg recognition [GO:0035036]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; single fertilization [GO:0007338]; sperm-egg recognition [GO:0035036]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9EQF4}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9EQF4}. Cell projection, microvillus membrane {ECO:0000269|PubMed:36070373}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9EQF4}. Note=GPI-anchored at the oolemma microvilli. {ECO:0000250|UniProtKB:Q9EQF4}.
A6ND36	reviewed	FA83G_HUMAN	Protein FAM83G (Protein associated with SMAD1)	FAM83G PAWS1	Homo sapiens (Human)	823	FUNCTION: Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}.		BMP signaling pathway [GO:0030509]	cytosol [GO:0005829]; nucleus [GO:0005634]	protein kinase binding [GO:0019901]	cytosol [GO:0005829]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; BMP signaling pathway [GO:0030509]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24554596}. Nucleus {ECO:0000269|PubMed:24554596}. Note=Detected predominantly in the cytosol. Upon BMP stimulation, a small portion localizes the nucleus. {ECO:0000269|PubMed:24554596}.
A6NDB9	reviewed	PALM3_HUMAN	Paralemmin-3	PALM3	Homo sapiens (Human)	673	FUNCTION: ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}.		negative regulation of cytokine-mediated signaling pathway [GO:0001960]; regulation of cell shape [GO:0008360]; response to lipopolysaccharide [GO:0032496]; Toll signaling pathway [GO:0008063]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; regulation of cell shape [GO:0008360]; response to lipopolysaccharide [GO:0032496]; Toll signaling pathway [GO:0008063]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
A6NDE4	reviewed	RBY1B_HUMAN	RNA-binding motif protein, Y chromosome, family 1 member B	RBMY1B	Homo sapiens (Human)	496	FUNCTION: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.	MISCELLANEOUS: The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.	male gonad development [GO:0008584]; mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; male gonad development [GO:0008584]; mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus.
A6NDG6	reviewed	PGP_HUMAN	Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP)	PGP	Homo sapiens (Human)	321	FUNCTION: Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity). {ECO:0000250|UniProtKB:Q8CHP8, ECO:0000269|PubMed:26755581}.		glycerol biosynthetic process [GO:0006114]; glycerophospholipid metabolic process [GO:0006650]; negative regulation of gluconeogenesis [GO:0045721]	cytoplasm [GO:0005737]	ADP phosphatase activity [GO:0043262]; glycerol-1-phosphatase activity [GO:0000121]; glycerol-3-phosphatase activity [GO:0043136]; magnesium ion binding [GO:0000287]; phosphoglycolate phosphatase activity [GO:0008967]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; ADP phosphatase activity [GO:0043262]; glycerol-1-phosphatase activity [GO:0000121]; glycerol-3-phosphatase activity [GO:0043136]; magnesium ion binding [GO:0000287]; phosphoglycolate phosphatase activity [GO:0008967]; protein tyrosine phosphatase activity [GO:0004725]; glycerol biosynthetic process [GO:0006114]; glycerophospholipid metabolic process [GO:0006650]; negative regulation of gluconeogenesis [GO:0045721]	
A6NDV4	reviewed	TMM8B_HUMAN	Transmembrane protein 8B (Nasopharyngeal carcinoma-associated gene 6 protein) (Protein NAG-5) (Protein NGX6)	TMEM8B C9orf127 NGX6	Homo sapiens (Human)	472	FUNCTION: May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion. {ECO:0000269|PubMed:15498789, ECO:0000269|PubMed:15723283, ECO:0000269|PubMed:17270023, ECO:0000269|PubMed:17641538}.		cell-matrix adhesion [GO:0007160]; regulation of mitotic cell cycle [GO:0007346]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cell-matrix adhesion [GO:0007160]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:17641538}; Multi-pass membrane protein {ECO:0000269|PubMed:17641538}. Cytoplasm {ECO:0000269|PubMed:17641538}. Nucleus {ECO:0000269|PubMed:17641538}. Mitochondrion {ECO:0000269|PubMed:17641538}. Endoplasmic reticulum {ECO:0000269|PubMed:17641538}. Note=Also detected in mitochondrion and endoplasmic reticulum (PubMed:17641538).
A6NED2	reviewed	RCCD1_HUMAN	RCC1 domain-containing protein 1	RCCD1	Homo sapiens (Human)	376	FUNCTION: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8 (PubMed:24981860). Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8 (PubMed:28455245). {ECO:0000269|PubMed:24981860, ECO:0000269|PubMed:28455245}.		chromatin organization [GO:0006325]	chromosome [GO:0005694]; cytosol [GO:0005829]; plasma membrane [GO:0005886]		chromosome [GO:0005694]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; chromatin organization [GO:0006325]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:24981860}. Note=Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3). {ECO:0000269|PubMed:24981860}.
A6NEM1	reviewed	GG6L9_HUMAN	Golgin subfamily A member 6-like protein 9	GOLGA6L9 GOLGA6L20	Homo sapiens (Human)	432							
A6NFA1	reviewed	TIKI2_HUMAN	Metalloprotease TIKI2 (EC 3.4.-.-) (Heart, kidney and adipose-enriched transmembrane protein homolog) (TRAB domain-containing protein 2B)	TRABD2B HKAT TIKI2	Homo sapiens (Human)	517	FUNCTION: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. {ECO:0000269|PubMed:22726442}.	MISCELLANEOUS: Was named TIKI in reference to large-headed humanoid in Polynesian mythology. {ECO:0000305|PubMed:22726442}.	negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein oxidation [GO:1904808]; positive regulation of protein-containing complex assembly [GO:0031334]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055]	membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; Wnt-protein binding [GO:0017147]	membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; Wnt-protein binding [GO:0017147]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein oxidation [GO:1904808]; positive regulation of protein-containing complex assembly [GO:0031334]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22726442}; Single-pass type I membrane protein {ECO:0000269|PubMed:22726442}.
A6NFQ2	reviewed	TCAF2_HUMAN	TRPM8 channel-associated factor 2 (TRP channel-associated factor 2)	TCAF2 FAM115C FAM139A	Homo sapiens (Human)	919	FUNCTION: [Isoform 2]: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner. {ECO:0000269|PubMed:25559186}.		negative regulation of anion channel activity [GO:0010360]; positive regulation of cell migration [GO:0030335]; positive regulation of protein targeting to membrane [GO:0090314]	cell junction [GO:0030054]; plasma membrane [GO:0005886]	transmembrane transporter binding [GO:0044325]	cell junction [GO:0030054]; plasma membrane [GO:0005886]; transmembrane transporter binding [GO:0044325]; negative regulation of anion channel activity [GO:0010360]; positive regulation of cell migration [GO:0030335]; positive regulation of protein targeting to membrane [GO:0090314]	SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:25559186}. Note=Colocalizes with TRPM8 on the plasma membrane. {ECO:0000269|PubMed:25559186}.
A6NFX1	reviewed	MFS2B_HUMAN	Sphingosine-1-phosphate transporter MFSD2B (Major facilitator superfamily domain-containing protein 2B) (hMfsd2b)	MFSD2B	Homo sapiens (Human)	504	FUNCTION: Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation (By similarity). Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate) (Probable). Release of sphingosine-1-phosphate is facilitated by a proton gradient (By similarity). In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport (Probable). In addition to export, also able to mediate S1P import (By similarity). Does not transport lysophosphatidylcholine (LPC) (Probable). {ECO:0000250|UniProtKB:Q3T9M1, ECO:0000269|PubMed:29045386, ECO:0000305|PubMed:29563527}.		carbohydrate transport [GO:0008643]; lipid transport [GO:0006869]; organic substance transport [GO:0071702]; positive regulation of platelet aggregation [GO:1901731]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]	plasma membrane [GO:0005886]	sphingolipid transporter activity [GO:0046624]; symporter activity [GO:0015293]	plasma membrane [GO:0005886]; sphingolipid transporter activity [GO:0046624]; symporter activity [GO:0015293]; carbohydrate transport [GO:0008643]; lipid transport [GO:0006869]; organic substance transport [GO:0071702]; positive regulation of platelet aggregation [GO:1901731]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29045386, ECO:0000269|PubMed:29563527}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the cell membrane and intracellular membranes. {ECO:0000269|PubMed:29045386}.
A6NFY7	reviewed	SDHF1_HUMAN	Succinate dehydrogenase assembly factor 1, mitochondrial (SDH assembly factor 1) (SDHAF1) (LYR motif-containing protein 8)	SDHAF1 LYRM8	Homo sapiens (Human)	115	FUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954417, PubMed:19465911). Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants (PubMed:24954417). May act together with SDHAF3 (PubMed:24954417). Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (PubMed:26749241). {ECO:0000269|PubMed:19465911, ECO:0000269|PubMed:24954417, ECO:0000269|PubMed:26749241}.	MISCELLANEOUS: Riboflavin supplementation, which is used as a treatment in SDHAF1-deficient patients, enhances SDHA flavinylation and activity and reduces levels of HIF1A, HIF2A and succinate. {ECO:0000269|PubMed:26749241}.	mitochondrial respiratory chain complex II assembly [GO:0034553]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]		mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; mitochondrial respiratory chain complex II assembly [GO:0034553]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:19465911}.
A6NGG8	reviewed	PCARE_HUMAN	Photoreceptor cilium actin regulator	PCARE C2orf71	Homo sapiens (Human)	1288	FUNCTION: Plays an essential role for normal photoreceptor cell maintenance and vision. {ECO:0000269|PubMed:20398886}.		photoreceptor cell outer segment organization [GO:0035845]; protein localization to photoreceptor outer segment [GO:1903546]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	cilium [GO:0005929]; cone photoreceptor outer segment [GO:0120199]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]		cilium [GO:0005929]; cone photoreceptor outer segment [GO:0120199]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; photoreceptor cell outer segment organization [GO:0035845]; protein localization to photoreceptor outer segment [GO:1903546]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:20398886}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q6PAC4}.
A6NGQ2	reviewed	OOEP_HUMAN	Oocyte-expressed protein homolog (KH homology domain-containing protein 2) (Oocyte- and embryo-specific protein 19) (hOEP19)	OOEP C6orf156 KHDC2 OEP19	Homo sapiens (Human)	149	FUNCTION: As part of the OOEP-KHDC3L scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes (By similarity). Thereby contributes to oocyte survival and the resumption and completion of meiosis (By similarity). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). {ECO:0000250|UniProtKB:Q9CWE6}.		actin filament organization [GO:0007015]; embryonic pattern specification [GO:0009880]; establishment of spindle localization [GO:0051293]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of meiotic nuclear division [GO:0045836]; regulation of cell division [GO:0051302]; regulation of establishment of protein localization [GO:0070201]; regulation of protein localization [GO:0032880]; replication fork processing [GO:0031297]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; subcortical maternal complex [GO:0106333]	RNA binding [GO:0003723]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; subcortical maternal complex [GO:0106333]; RNA binding [GO:0003723]; actin filament organization [GO:0007015]; embryonic pattern specification [GO:0009880]; establishment of spindle localization [GO:0051293]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of meiotic nuclear division [GO:0045836]; regulation of cell division [GO:0051302]; regulation of establishment of protein localization [GO:0070201]; regulation of protein localization [GO:0032880]; replication fork processing [GO:0031297]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25542835}. Nucleus {ECO:0000269|PubMed:25542835}.
A6NGU5	reviewed	GGT3_HUMAN	Putative glutathione hydrolase 3 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 3) (Putative gamma-glutamyltranspeptidase 3) (GGT 3) (EC 2.3.2.2) [Cleaved into: Putative glutathione hydrolase 3 heavy chain; Putative glutathione hydrolase 3 light chain]	GGT3P GGT3	Homo sapiens (Human)	568	FUNCTION: Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. {ECO:0000250|UniProtKB:P19440}.		glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]; peptide modification [GO:0031179]; proteolysis [GO:0006508]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]; peptide modification [GO:0031179]; proteolysis [GO:0006508]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P19440}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P07314}.
A6NHL2	reviewed	TBAL3_HUMAN	Tubulin alpha chain-like 3 (EC 3.6.5.-)	TUBAL3	Homo sapiens (Human)	446	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	cytoplasm [GO:0005737]; microtubule [GO:0005874]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
A6NHR9	reviewed	SMHD1_HUMAN	Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-)	SMCHD1 KIAA0650	Homo sapiens (Human)	2005	FUNCTION: Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:25294876, PubMed:24790221). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}.		chromosome organization [GO:0051276]; dosage compensation by inactivation of X chromosome [GO:0009048]; double-strand break repair [GO:0006302]; inactivation of X chromosome by heterochromatin formation [GO:0060820]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; nose development [GO:0043584]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]	Barr body [GO:0001740]; site of double-strand break [GO:0035861]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; protein homodimerization activity [GO:0042803]	Barr body [GO:0001740]; site of double-strand break [GO:0035861]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; protein homodimerization activity [GO:0042803]; chromosome organization [GO:0051276]; dosage compensation by inactivation of X chromosome [GO:0009048]; double-strand break repair [GO:0006302]; inactivation of X chromosome by heterochromatin formation [GO:0060820]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; nose development [GO:0043584]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876}. Note=Recruited to inactivated chromosome X in females by Xist RNA (By similarity). Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:25294876, PubMed:24790221). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876}.
A6NHX0	reviewed	CAST2_HUMAN	Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2)	CASTOR2 GATSL1 GATSL2	Homo sapiens (Human)	329	FUNCTION: Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. {ECO:0000269|PubMed:26972053}.		cellular response to L-arginine [GO:1903577]; negative regulation of TORC1 signaling [GO:1904262]	cytosol [GO:0005829]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; identical protein binding [GO:0042802]; cellular response to L-arginine [GO:1903577]; negative regulation of TORC1 signaling [GO:1904262]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:26972053}.
A6NI15	reviewed	MSGN1_HUMAN	Mesogenin-1 (Paraxial mesoderm-specific mesogenin1) (pMesogenin1) (pMsgn1)	MSGN1	Homo sapiens (Human)	193	FUNCTION: Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; mesoderm formation [GO:0001707]; regulation of transcription by RNA polymerase II [GO:0006357]; segment specification [GO:0007379]; somitogenesis [GO:0001756]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; mesoderm formation [GO:0001707]; regulation of transcription by RNA polymerase II [GO:0006357]; segment specification [GO:0007379]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
A6NI61	reviewed	MYMK_HUMAN	Protein myomaker (Myoblast fusion maker) (Transmembrane protein 226) (Transmembrane protein 8C)	MYMK TMEM226 TMEM8C	Homo sapiens (Human)	221	FUNCTION: Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:28681861). Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX. Acts independently of MYMX (By similarity). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (By similarity). Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satellite cells with myofibers (By similarity). {ECO:0000250|UniProtKB:Q9D1N4, ECO:0000269|PubMed:28681861}.		muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; plasma membrane fusion [GO:0045026]; positive regulation of skeletal muscle hypertrophy [GO:1904206]	Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]		Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; plasma membrane fusion [GO:0045026]; positive regulation of skeletal muscle hypertrophy [GO:1904206]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9D1N4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9D1N4}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9D1N4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9D1N4}. Note=Localizes on the plasma membrane of myoblasts, where it mediates myoblasts fusion. Also localizes in the Golgi apparatus and post-Golgi following palmitoylation; the role of Golgi localization is unclear. {ECO:0000250|UniProtKB:Q9D1N4}.
A6NI73	reviewed	LIRA5_HUMAN	Leukocyte immunoglobulin-like receptor subfamily A member 5 (CD85 antigen-like family member F) (Immunoglobulin-like transcript 11) (ILT-11) (Leukocyte immunoglobulin-like receptor 9) (LIR-9) (CD antigen CD85f)	LILRA5 ILT11 LILRB7 LIR9	Homo sapiens (Human)	299	FUNCTION: May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition. {ECO:0000269|PubMed:16675463}.		cytokine-mediated signaling pathway [GO:0019221]; innate immune response [GO:0045087]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-13 production [GO:0032696]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell activation [GO:0050867]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of tumor necrosis factor production [GO:0032760]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	inhibitory MHC class I receptor activity [GO:0032396]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; inhibitory MHC class I receptor activity [GO:0032396]; cytokine-mediated signaling pathway [GO:0019221]; innate immune response [GO:0045087]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-13 production [GO:0032696]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell activation [GO:0050867]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of tumor necrosis factor production [GO:0032760]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12393390}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:12393390}.
A6NIH7	reviewed	U119B_HUMAN	Protein unc-119 homolog B	UNC119B	Homo sapiens (Human)	251	FUNCTION: Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells. {ECO:0000269|PubMed:22085962}.		cilium assembly [GO:0060271]; lipoprotein transport [GO:0042953]; nervous system development [GO:0007399]	ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]	lipid binding [GO:0008289]	ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; lipid binding [GO:0008289]; cilium assembly [GO:0060271]; lipoprotein transport [GO:0042953]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:22085962}. Note=Enriched at the transition zone and extended into the proximal end of the cilium.
A6NIX2	reviewed	WTIP_HUMAN	Wilms tumor protein 1-interacting protein (WT1-interacting protein)	WTIP	Homo sapiens (Human)	430	FUNCTION: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:A9LS46, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.		cell projection organization [GO:0030030]; cytoskeleton organization [GO:0007010]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of hippo signaling [GO:0035331]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; regulation of cell morphogenesis [GO:0022604]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]	adherens junction [GO:0005912]; nucleus [GO:0005634]; P-body [GO:0000932]; transcription regulator complex [GO:0005667]	metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	adherens junction [GO:0005912]; nucleus [GO:0005634]; P-body [GO:0000932]; transcription regulator complex [GO:0005667]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; cell projection organization [GO:0030030]; cytoskeleton organization [GO:0007010]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of hippo signaling [GO:0035331]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; regulation of cell morphogenesis [GO:0022604]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Cell junction, adherens junction. Nucleus {ECO:0000250}. Cytoplasm, P-body. Note=Following podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide, translocates from sites of cell-cell contacts into the cytosol and nucleus. The shift from cell contacts to intracellular plaques starts as early as 1 hour after LPS stimulation and intranuclear localization begins 3 hours after LPS treatment. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell contacts 24 hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane (By similarity). {ECO:0000250}.
A6NJ46	reviewed	NKX63_HUMAN	Homeobox protein Nkx-6.3	NKX6-3	Homo sapiens (Human)	265	FUNCTION: Putative transcription factor, which may be involved in patterning of central nervous system and pancreas. {ECO:0000250}.		cell differentiation [GO:0030154]; cell fate determination [GO:0001709]; enteroendocrine cell differentiation [GO:0035883]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; cell fate determination [GO:0001709]; enteroendocrine cell differentiation [GO:0035883]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A6NJ78	reviewed	MET15_HUMAN	12S rRNA N4-methylcytidine (m4C) methyltransferase (12S rRNA m4C methyltransferase) (EC 2.1.1.-) (Methyltransferase 5 domain-containing protein 1) (Methyltransferase-like protein 15)	METTL15 METT5D1	Homo sapiens (Human)	407	FUNCTION: N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA (PubMed:31665743, PubMed:32371392). Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits (PubMed:31665743, PubMed:32371392). {ECO:0000269|PubMed:31665743, ECO:0000269|PubMed:32371392}.		rRNA base methylation [GO:0070475]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	rRNA (cytosine-N4-)-methyltransferase activity [GO:0071424]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; rRNA (cytosine-N4-)-methyltransferase activity [GO:0071424]; rRNA base methylation [GO:0070475]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:31665743, ECO:0000269|PubMed:32371392}.
A6NK06	reviewed	IRG1_HUMAN	Cis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein)	ACOD1 IRG1	Homo sapiens (Human)	481	FUNCTION: Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393, PubMed:31548418, PubMed:35662396). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB (PubMed:23610393, PubMed:35662396). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Plays a role in the embryo implantation (By similarity). {ECO:0000250|UniProtKB:P54987, ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393, ECO:0000269|PubMed:31548418, ECO:0000269|PubMed:35662396}.		cellular response to interferon-beta [GO:0035458]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to molecule of bacterial origin [GO:0071219]; cellular response to progesterone stimulus [GO:0071393]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; defense response [GO:0006952]; defense response to virus [GO:0051607]; embryo implantation [GO:0007566]; inflammatory response [GO:0006954]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of type I interferon production [GO:0032480]; positive regulation of antimicrobial humoral response [GO:0002760]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; tolerance induction to lipopolysaccharide [GO:0072573]	mitochondrion [GO:0005739]	aconitate decarboxylase activity [GO:0047613]; protein homodimerization activity [GO:0042803]	mitochondrion [GO:0005739]; aconitate decarboxylase activity [GO:0047613]; protein homodimerization activity [GO:0042803]; cellular response to interferon-beta [GO:0035458]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to molecule of bacterial origin [GO:0071219]; cellular response to progesterone stimulus [GO:0071393]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; defense response [GO:0006952]; defense response to virus [GO:0051607]; embryo implantation [GO:0007566]; inflammatory response [GO:0006954]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of type I interferon production [GO:0032480]; positive regulation of antimicrobial humoral response [GO:0002760]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; tolerance induction to lipopolysaccharide [GO:0072573]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P54987}.
A6NK58	reviewed	LIPT2_HUMAN	Putative lipoyltransferase 2, mitochondrial (EC 2.3.1.181) (Lipoate-protein ligase B) (Lipoyl/octanoyl transferase) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase)	LIPT2	Homo sapiens (Human)	231	FUNCTION: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes, which catalyze essential redox reactions (PubMed:28757203). Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). {ECO:0000250, ECO:0000269|PubMed:28757203}.	MISCELLANEOUS: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. {ECO:0000250}.	carboxylic acid metabolic process [GO:0019752]; positive regulation of oxygen metabolic process [GO:2000376]; protein lipoylation [GO:0009249]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ligase activity [GO:0016874]; lipoyl(octanoyl) transferase activity [GO:0033819]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ligase activity [GO:0016874]; lipoyl(octanoyl) transferase activity [GO:0033819]; carboxylic acid metabolic process [GO:0019752]; positive regulation of oxygen metabolic process [GO:2000376]; protein lipoylation [GO:0009249]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:28628643, ECO:0000269|PubMed:28757203}.
A6NK89	reviewed	RASFA_HUMAN	Ras association domain-containing protein 10	RASSF10	Homo sapiens (Human)	507	FUNCTION: Plays an important role in regulating embryonic neurogenesis. {ECO:0000250|UniProtKB:Q8BL43}.		nervous system development [GO:0007399]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; signal transduction [GO:0007165]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; spindle pole [GO:0000922]		cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; spindle pole [GO:0000922]; nervous system development [GO:0007399]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20956940}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20956940}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20956940}. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm.
A6NKB5	reviewed	PCX2_HUMAN	Pecanex-like protein 2 (Pecanex homolog protein 2)	PCNX2 KIAA0435 PCNXL2	Homo sapiens (Human)	2137	FUNCTION: May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). {ECO:0000269|PubMed:12140758, ECO:0000269|PubMed:14507650}.	MISCELLANEOUS: PCNXL2 is characterized by high mutational frequencies and biallelic mutations in MSI-H colorectal tumors, and is thus likely to be a target gene in these tumors.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NMY6	reviewed	AXA2L_HUMAN	Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene)	ANXA2P2 ANX2L2 ANX2P2 LPC2B	Homo sapiens (Human)	339	FUNCTION: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}.	MISCELLANEOUS: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. {ECO:0000250}.		basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; cytoskeletal protein binding [GO:0008092]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; phospholipase A2 inhibitor activity [GO:0019834]; protease binding [GO:0002020]; virion binding [GO:0046790]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; cytoskeletal protein binding [GO:0008092]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; phospholipase A2 inhibitor activity [GO:0019834]; protease binding [GO:0002020]; virion binding [GO:0046790]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Melanosome {ECO:0000250}. Note=In the lamina beneath the plasma membrane. In melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. {ECO:0000250}.
A6NMZ7	reviewed	CO6A6_HUMAN	Collagen alpha-6(VI) chain	COL6A6	Homo sapiens (Human)	2263	FUNCTION: Collagen VI acts as a cell-binding protein. {ECO:0000250}.		cell adhesion [GO:0007155]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]		collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Deposed in the extracellular matrix of skeletal muscle. {ECO:0000250}.
A6NNB3	reviewed	IFM5_HUMAN	Interferon-induced transmembrane protein 5 (Bone-restricted interferon-induced transmembrane protein-like protein) (BRIL) (Dispanin subfamily A member 1) (DSPA1)	IFITM5	Homo sapiens (Human)	132	FUNCTION: Required for normal bone mineralization. {ECO:0000269|PubMed:24519609}.		bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; in utero embryonic development [GO:0001701]; regulation of bone mineralization [GO:0030500]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; in utero embryonic development [GO:0001701]; regulation of bone mineralization [GO:0030500]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24519609}; Multi-pass membrane protein {ECO:0000255}.
A6NNM8	reviewed	TTL13_HUMAN	Tubulin polyglutamylase TTLL13 (EC 6.3.2.-) (Tubulin tyrosine ligase like 13) (Tubulin tyrosine ligase-like family member 13 pseudogene) (Tubulin--tyrosine ligase-like protein 13)	TTLL13 TTLL13P	Homo sapiens (Human)	815	FUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Mediates ATP-dependent polyglutamate side-chain elongation of the polyglutamylation reaction but not the initiation step. Preferentially modifies the alpha-tubulin tail over a beta-tail. {ECO:0000250|UniProtKB:A4Q9F6}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211]	cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]; microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211]	
A6NNN8	reviewed	S38A8_HUMAN	Solute carrier family 38 member 8 (Amino acid transporter SLC38A8)	SLC38A8	Homo sapiens (Human)	435	FUNCTION: Electrogenic sodium-dependent amino acid transporter with a preference for L-glutamine, L-alanine, L-histidine, L-aspartate and L-arginine. May facilitate glutamine uptake in both excitatory and inhibitory neurons. The transport mechanism and stoichiometry remain to be elucidated. {ECO:0000250|UniProtKB:Q5HZH7}.		amino acid transmembrane transport [GO:0003333]; sodium ion transport [GO:0006814]	membrane [GO:0016020]	L-amino acid transmembrane transporter activity [GO:0015179]	membrane [GO:0016020]; L-amino acid transmembrane transporter activity [GO:0015179]; amino acid transmembrane transport [GO:0003333]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q5HZH7}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q5HZH7}. Cell projection, axon {ECO:0000250|UniProtKB:Q5HZH7}.
A6NNY8	reviewed	UBP27_HUMAN	Ubiquitin carboxyl-terminal hydrolase 27 (EC 3.4.19.12) (Deubiquitinating enzyme 27) (Ubiquitin carboxyl-terminal hydrolase 22-like) (Ubiquitin thioesterase 27) (Ubiquitin-specific-processing protease 27) (X-linked ubiquitin carboxyl-terminal hydrolase 27)	USP27X USP22L USP27	Homo sapiens (Human)	438	FUNCTION: Deubiquitinase involved in innate antiviral immunity by mediating deubiquitination of CGAS and RIGI (PubMed:31534008, PubMed:32027733). Negatively regulates RIGI by mediating 'Lys-63'-linked deubiquitination of RIGI, inhibiting type I interferon signaling (PubMed:32027733). Also regulates 'Lys-63'-linked ubiquitination level of MDA5/IFIH1 (PubMed:32027733). Acts as a positive regulator of the cGAS-STING pathway by catalyzing 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization (PubMed:31534008). Can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal (By similarity). By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity (By similarity). {ECO:0000250|UniProtKB:Q8CEG8, ECO:0000269|PubMed:31534008, ECO:0000269|PubMed:32027733}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of apoptotic process [GO:0043065]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]	cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]	cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of apoptotic process [GO:0043065]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8CEG8}. Nucleus {ECO:0000250|UniProtKB:Q8CEG8}.
A6NNZ2	reviewed	TBB8B_HUMAN	Tubulin beta 8B	TUBB8B	Homo sapiens (Human)	444	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
A6PVC2	reviewed	TTLL8_HUMAN	Protein monoglycylase TTLL8 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 8)	TTLL8	Homo sapiens (Human)	850	FUNCTION: Monoglycylase which modifies both tubulin and non-tubulin proteins, adding a single glycine to the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of target proteins. Not involved in elongation step of the polyglycylation reaction. Preferentially monoglycylates alpha-tubulin over beta-tubulin. Together with TTLL3, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance. Together with TTLL3, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility. Monoglycylates non-tubulin proteins such as ANP32A, ANP32B, SET, NCL and NAP1. {ECO:0000250|UniProtKB:A4Q9F1}.		cilium assembly [GO:0060271]; cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]; protein polyglycylation [GO:0018094]	axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; sperm flagellum [GO:0036126]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glycine ligase activity [GO:0070735]; protein-glycine ligase activity, initiating [GO:0070736]	axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; sperm flagellum [GO:0036126]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glycine ligase activity [GO:0070735]; protein-glycine ligase activity, initiating [GO:0070736]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]; protein polyglycylation [GO:0018094]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A4Q9F1}. Cell projection, cilium {ECO:0000250|UniProtKB:A4Q9F1}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A4Q9F1}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A4Q9F1}.
A7E2V4	reviewed	ZSWM8_HUMAN	Zinc finger SWIM domain-containing protein 8	ZSWIM8 KIAA0913	Homo sapiens (Human)	1837	FUNCTION: Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). {ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.		positive regulation of miRNA catabolic process [GO:2000627]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; target-directed miRNA degradation [GO:0140958]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]	ubiquitin ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270]; positive regulation of miRNA catabolic process [GO:2000627]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; target-directed miRNA degradation [GO:0140958]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q3UHH1}.
A7E2Y1	reviewed	MYH7B_HUMAN	Myosin-7B (Antigen MLAA-21) (Myosin cardiac muscle beta chain) (Myosin heavy chain 7B, cardiac muscle beta isoform) (Slow A MYH14)	MYH7B KIAA1512	Homo sapiens (Human)	1983	FUNCTION: Involved in muscle contraction. {ECO:0000269|PubMed:11919279}.	MISCELLANEOUS: Expression does not vary in normal patients compared to patients with acute monocytic leukemia.; MISCELLANEOUS: The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.		cytoplasm [GO:0005737]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]	cytoplasm [GO:0005737]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15755502}; Peripheral membrane protein {ECO:0000269|PubMed:15755502}.
A7KAX9	reviewed	RHG32_HUMAN	Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)	ARHGAP32 GRIT KIAA0712 RICS	Homo sapiens (Human)	2087	FUNCTION: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.		regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]	GTPase activator activity [GO:0005096]; phosphatidylinositol phosphate binding [GO:1901981]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; GTPase activator activity [GO:0005096]; phosphatidylinositol phosphate binding [GO:1901981]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250|UniProtKB:Q811P8}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q811P8}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12446789}. Endosome membrane {ECO:0000269|PubMed:17663722}. Golgi apparatus membrane {ECO:0000269|PubMed:17663722}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q811P8}. Membrane {ECO:0000269|PubMed:17663722}. Note=Association to membrane via PX domain (PubMed:17663722). Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane upon EGF treatment (PubMed:12446789). Colocalizes with GAB2 at the cell membrane (PubMed:12819203). {ECO:0000250|UniProtKB:Q811P8, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:17663722}.
A7MCY6	reviewed	TBKB1_HUMAN	TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)	TBKBP1 KIAA0775 SINTBAD	Homo sapiens (Human)	615	FUNCTION: Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}.		canonical NF-kappaB signal transduction [GO:0007249]; defense response to virus [GO:0051607]; type I interferon-mediated signaling pathway [GO:0060337]	cytoplasm [GO:0005737]; serine/threonine protein kinase complex [GO:1902554]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; serine/threonine protein kinase complex [GO:1902554]; metal ion binding [GO:0046872]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to virus [GO:0051607]; type I interferon-mediated signaling pathway [GO:0060337]	
A7MD48	reviewed	SRRM4_HUMAN	Serine/arginine repetitive matrix protein 4 (Medulloblastoma antigen MU-MB-2.76) (Neural-specific serine/arginine repetitive splicing factor of 100 kDa) (Neural-specific SR-related protein of 100 kDa) (nSR100)	SRRM4 KIAA1853	Homo sapiens (Human)	611	FUNCTION: Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:30684677). Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (By similarity). {ECO:0000250|UniProtKB:Q8BKA3, ECO:0000269|PubMed:30684677}.		cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; nervous system development [GO:0007399]; neuron maturation [GO:0042551]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; sensory perception of sound [GO:0007605]	nucleus [GO:0005634]	identical protein binding [GO:0042802]; mRNA binding [GO:0003729]	nucleus [GO:0005634]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; nervous system development [GO:0007399]; neuron maturation [GO:0042551]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BKA3}.
A7XYQ1	reviewed	SOBP_HUMAN	Sine oculis-binding protein homolog (Jackson circler protein 1)	SOBP JXC1	Homo sapiens (Human)	873	FUNCTION: Implicated in development of the cochlea. {ECO:0000250|UniProtKB:Q0P5V2}.		animal organ development [GO:0048513]; cochlea development [GO:0090102]; cognition [GO:0050890]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605]	nucleus [GO:0005634]	metal ion binding [GO:0046872]; SUMO polymer binding [GO:0032184]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; SUMO polymer binding [GO:0032184]; animal organ development [GO:0048513]; cochlea development [GO:0090102]; cognition [GO:0050890]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605]	
A8CG34	reviewed	P121C_HUMAN	Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C)	POM121C	Homo sapiens (Human)	1229	FUNCTION: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.		mRNA transport [GO:0051028]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]	endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]	nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]	endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]; mRNA transport [GO:0051028]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:17900573}. Nucleus membrane {ECO:0000269|PubMed:17900573}; Single-pass membrane protein {ECO:0000269|PubMed:17900573}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase. {ECO:0000250}.
A8K0Z3	reviewed	WASH1_HUMAN	WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1)	WASHC1 FAM39E WASH1	Homo sapiens (Human)	465	FUNCTION: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853, ECO:0000305|PubMed:20498093}.	MISCELLANEOUS: WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units. Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene. {ECO:0000305|PubMed:18159949}.	Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; extracellular matrix disassembly [GO:0022617]; negative regulation of autophagy [GO:0010507]; negative regulation of phosphatidylinositol 3-kinase activity [GO:0043553]; positive regulation of cell migration [GO:0030335]; positive regulation of pseudopodium assembly [GO:0031274]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of protein ubiquitination [GO:0031396]; retrograde transport, endosome to Golgi [GO:0042147]	autophagosome [GO:0005776]; centriole [GO:0005814]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]; ubiquitin protein ligase binding [GO:0031625]	autophagosome [GO:0005776]; centriole [GO:0005814]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]; ubiquitin protein ligase binding [GO:0031625]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; extracellular matrix disassembly [GO:0022617]; negative regulation of autophagy [GO:0010507]; negative regulation of phosphatidylinositol 3-kinase activity [GO:0043553]; positive regulation of cell migration [GO:0030335]; positive regulation of pseudopodium assembly [GO:0031274]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of protein ubiquitination [GO:0031396]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:19922874}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8VDD8}. Late endosome {ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:24344185}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q8VDD8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8VDD8}. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2 (PubMed:19922874). Localizes to MMP14-positive late endosomes and transiently to invadipodia (PubMed:24344185). Localized to Salmonella typhimurium entry sites (By similarity). {ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:24344185}.
A8K2U0	reviewed	A2ML1_HUMAN	Alpha-2-macroglobulin-like protein 1 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9)	A2ML1 CPAMD9	Homo sapiens (Human)	1454	FUNCTION: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. {ECO:0000250|UniProtKB:P01023, ECO:0000269|PubMed:16298998}.		regulation of endopeptidase activity [GO:0052548]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	peptidase inhibitor activity [GO:0030414]; serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; peptidase inhibitor activity [GO:0030414]; serine-type endopeptidase inhibitor activity [GO:0004867]; regulation of endopeptidase activity [GO:0052548]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16298998}.
A8K4G0	reviewed	CLM7_HUMAN	CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor expressed on myeloid cells 5) (TREM-5) (CD antigen CD300b)	CD300LB CD300B CLM7 CMRF35A2 IREM3 LMIR5 TREM5 UNQ2530/PRO6029	Homo sapiens (Human)	201	FUNCTION: Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. {ECO:0000269|PubMed:16920917, ECO:0000269|PubMed:17928527}.		immune system process [GO:0002376]	plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]; immune system process [GO:0002376]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
A8K7I4	reviewed	CLCA1_HUMAN	Calcium-activated chloride channel regulator 1 (EC 3.4.-.-) (Calcium-activated chloride channel family member 1) (hCLCA1) (Calcium-activated chloride channel protein 1) (CaCC-1) (hCaCC-1)	CLCA1 CACC1	Homo sapiens (Human)	914	FUNCTION: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:11842292, ECO:0000269|PubMed:11956057, ECO:0000269|PubMed:23112050, ECO:0000269|PubMed:9828122}.		calcium ion transport [GO:0006816]; cellular response to hypoxia [GO:0071456]; monoatomic ion transmembrane transport [GO:0034220]; proteolysis [GO:0006508]	extracellular space [GO:0005615]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; zymogen granule membrane [GO:0042589]	chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	extracellular space [GO:0005615]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; zymogen granule membrane [GO:0042589]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; calcium ion transport [GO:0006816]; cellular response to hypoxia [GO:0071456]; monoatomic ion transmembrane transport [GO:0034220]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:15919655}. Cell membrane {ECO:0000269|PubMed:15919655}; Peripheral membrane protein {ECO:0000269|PubMed:15919655}; Extracellular side {ECO:0000269|PubMed:15919655}. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
A8K830	reviewed	OCAT2_HUMAN	POU class 2 homeobox associating factor 3 (Cancer susceptibility candidate protein 13) (Colorectal cancer-associated protein 2) (Protein OCA-T2)	POU2AF3 C11orf93 CASC13 COLCA2	Homo sapiens (Human)	251	FUNCTION: Transcriptional coactivator that specifically associates with POU2F3 (PubMed:35576971). This complex drives the development of tuft cells, a rare a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971). {ECO:0000269|PubMed:35576971}.			cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA binding [GO:0003677]; POU domain binding [GO:0070974]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; POU domain binding [GO:0070974]; transcription coactivator activity [GO:0003713]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24154973}. Nucleus {ECO:0000269|PubMed:35576971}.
A8K8P3	reviewed	SFI1_HUMAN	Protein SFI1 homolog (hSFI1)	SFI1 KIAA0542	Homo sapiens (Human)	1242	FUNCTION: Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2. {ECO:0000269|PubMed:16956364}.			centriole [GO:0005814]; cytosol [GO:0005829]	phosphatase binding [GO:0019902]	centriole [GO:0005814]; cytosol [GO:0005829]; phosphatase binding [GO:0019902]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:14504268, ECO:0000269|PubMed:16956364}. Note=Localized close to the centriole.
A8K8V0	reviewed	ZN785_HUMAN	Zinc finger protein 785	ZNF785	Homo sapiens (Human)	405	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A8MPY1	reviewed	GBRR3_HUMAN	Gamma-aminobutyric acid receptor subunit rho-3 (GABA(A) receptor subunit rho-3) (GABA(C) receptor)	GABRR3	Homo sapiens (Human)	467	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. {ECO:0000250}.		chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]	chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594]	chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
A8MQ03	reviewed	CRTP1_HUMAN	Cysteine-rich tail protein 1	CYSRT1 C9orf169	Homo sapiens (Human)	144	FUNCTION: Component of the stratum corneum that may contribute to epidermal antimicrobial host defenses. {ECO:0000269|PubMed:36804407}.		biological process involved in interaction with symbiont [GO:0051702]; establishment of skin barrier [GO:0061436]	cornified envelope [GO:0001533]; extracellular exosome [GO:0070062]	identical protein binding [GO:0042802]	cornified envelope [GO:0001533]; extracellular exosome [GO:0070062]; identical protein binding [GO:0042802]; biological process involved in interaction with symbiont [GO:0051702]; establishment of skin barrier [GO:0061436]	SUBCELLULAR LOCATION: Cornified envelope {ECO:0000269|PubMed:36804407}.
A8MQ27	reviewed	NEU1B_HUMAN	E3 ubiquitin-protein ligase NEURL1B (EC 2.3.2.27) (Neuralized-2) (NEUR2) (Neuralized-like protein 1B) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL1B)	NEURL1B NEURL3	Homo sapiens (Human)	555	FUNCTION: E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands. {ECO:0000269|PubMed:19723503}.		Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; ubiquitin-dependent endocytosis [GO:0070086]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; early endosome [GO:0005769]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; early endosome [GO:0005769]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; ubiquitin-dependent endocytosis [GO:0070086]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19723503}.
A8MT69	reviewed	CENPX_HUMAN	Centromere protein X (CENP-X) (FANCM-associated histone fold protein 2) (FANCM-interacting histone fold protein 2) (Fanconi anemia-associated polypeptide of 10 kDa) (Retinoic acid-inducible gene D9 protein homolog) (Stimulated by retinoic acid gene 13 protein homolog)	CENPX FAAP10 MHF2 STRA13	Homo sapiens (Human)	81	FUNCTION: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:20347429). DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347429). {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429}.		cell division [GO:0051301]; chromosome segregation [GO:0007059]; interstrand cross-link repair [GO:0036297]; kinetochore assembly [GO:0051382]; positive regulation of protein ubiquitination [GO:0031398]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]	chromatin [GO:0000785]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]	chromatin [GO:0000785]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; interstrand cross-link repair [GO:0036297]; kinetochore assembly [GO:0051382]; positive regulation of protein ubiquitination [GO:0031398]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}. Chromosome, centromere {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPX being less stably bound at the kinetochore than CENPS. {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}.
A8MTA8	reviewed	CMI2B_HUMAN	Ciliary microtubule inner protein 2B	CIMIP2B FAM166B	Homo sapiens (Human)	275	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.			axonemal microtubule [GO:0005879]		axonemal microtubule [GO:0005879]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
A8MTJ3	reviewed	GNAT3_HUMAN	Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain)	GNAT3	Homo sapiens (Human)	354	FUNCTION: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. {ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:17724330}.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; response to nicotine [GO:0035094]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917]	acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; axoneme [GO:0005930]; heterotrimeric G-protein complex [GO:0005834]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; axoneme [GO:0005930]; heterotrimeric G-protein complex [GO:0005834]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; response to nicotine [GO:0035094]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8015379}. Note=Dual distribution pattern; plasmalemmal pattern with apical region localization and cytosolic pattern with localization throughout the cytoplasm.
A8MTJ6	reviewed	FOXI3_HUMAN	Forkhead box protein I3	FOXI3	Homo sapiens (Human)	420	FUNCTION: Transcription factor required for pharyngeal arch development, which is involved in hair, ear, jaw and dental development (PubMed:37041148). May act as a pioneer transcription factor during pharyngeal arch development (By similarity). Required for epithelial cell differentiation within the epidermis (By similarity). Acts at multiple stages of otic placode induction: necessary for preplacodal ectoderm to execute an inner ear program (By similarity). Required for hair follicle stem cell specification (By similarity). Acts downstream of TBX1 for the formation of the thymus and parathyroid glands from the third pharyngeal pouch (By similarity). {ECO:0000250|UniProtKB:D3Z120, ECO:0000269|PubMed:37041148}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; epidermal cell fate specification [GO:0009957]; hair follicle development [GO:0001942]; odontogenesis of dentin-containing tooth [GO:0042475]; otic placode development [GO:1905040]; parathyroid gland development [GO:0060017]; pharyngeal system development [GO:0060037]; regulation of transcription by RNA polymerase II [GO:0006357]; thymus development [GO:0048538]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; epidermal cell fate specification [GO:0009957]; hair follicle development [GO:0001942]; odontogenesis of dentin-containing tooth [GO:0042475]; otic placode development [GO:1905040]; parathyroid gland development [GO:0060017]; pharyngeal system development [GO:0060037]; regulation of transcription by RNA polymerase II [GO:0006357]; thymus development [GO:0048538]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:37041148}.
A8MTQ0	reviewed	NOTO_HUMAN	Homeobox protein notochord	NOTO	Homo sapiens (Human)	251	FUNCTION: Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (By similarity). {ECO:0000250|UniProtKB:Q5TIS6}.		central nervous system development [GO:0007417]; dorsal/ventral pattern formation [GO:0009953]; embryonic pattern specification [GO:0009880]; heart looping [GO:0001947]; motile cilium assembly [GO:0044458]; neuron differentiation [GO:0030182]; notochord development [GO:0030903]; regulation of cilium assembly [GO:1902017]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; central nervous system development [GO:0007417]; dorsal/ventral pattern formation [GO:0009953]; embryonic pattern specification [GO:0009880]; heart looping [GO:0001947]; motile cilium assembly [GO:0044458]; neuron differentiation [GO:0030182]; notochord development [GO:0030903]; regulation of cilium assembly [GO:1902017]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A8MTZ0	reviewed	BBIP1_HUMAN	BBSome-interacting protein 1 (BBSome-interacting protein of 10 kDa)	BBIP1 BBIP10 NCRNA00081	Homo sapiens (Human)	92	FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for primary cilia assembly and BBSome stability. Regulates cytoplasmic microtubule stability and acetylation. {ECO:0000269|Ref.4}.		cilium assembly [GO:0060271]; eating behavior [GO:0042755]; protein transport [GO:0015031]; receptor localization to non-motile cilium [GO:0097500]	BBSome [GO:0034464]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytosol [GO:0005829]		BBSome [GO:0034464]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cilium assembly [GO:0060271]; eating behavior [GO:0042755]; protein transport [GO:0015031]; receptor localization to non-motile cilium [GO:0097500]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|Ref.4}. Cytoplasm {ECO:0000269|Ref.4}. Note=Localizes inside the primary cilium but not at centriolar satellites.
A8MU46	reviewed	SMTL1_HUMAN	Smoothelin-like protein 1	SMTNL1	Homo sapiens (Human)	494	FUNCTION: Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity). {ECO:0000250}.		actin cytoskeleton organization [GO:0030036]; muscle organ morphogenesis [GO:0048644]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of vasoconstriction [GO:0045907]; response to activity [GO:0014823]; response to xenobiotic stimulus [GO:0009410]; vasoconstriction [GO:0042310]	contractile fiber [GO:0043292]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; I band [GO:0031674]; M band [GO:0031430]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]	calmodulin binding [GO:0005516]; CH domain binding [GO:0051401]; disordered domain specific binding [GO:0097718]; protein phosphatase 1 binding [GO:0008157]; protein self-association [GO:0043621]; tropomyosin binding [GO:0005523]	contractile fiber [GO:0043292]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; I band [GO:0031674]; M band [GO:0031430]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; calmodulin binding [GO:0005516]; CH domain binding [GO:0051401]; disordered domain specific binding [GO:0097718]; protein phosphatase 1 binding [GO:0008157]; protein self-association [GO:0043621]; tropomyosin binding [GO:0005523]; actin cytoskeleton organization [GO:0030036]; muscle organ morphogenesis [GO:0048644]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of vasoconstriction [GO:0045907]; response to activity [GO:0014823]; response to xenobiotic stimulus [GO:0009410]; vasoconstriction [GO:0042310]	SUBCELLULAR LOCATION: Cytoplasm, myofibril {ECO:0000269|PubMed:18310078}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus (By similarity). {ECO:0000250}.
A8MUP2	reviewed	CSKMT_HUMAN	Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial (CS-KMT) (EC 2.1.1.-) (Methyltransferase-like protein 12, mitochondrial)	CSKMT METTL12	Homo sapiens (Human)	240	FUNCTION: Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria (PubMed:28391595, PubMed:28887308). Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methyl group per binding event (PubMed:28887308). {ECO:0000269|PubMed:28391595, ECO:0000269|PubMed:28887308}.		peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; peptidyl-lysine trimethylation [GO:0018023]; protein methylation [GO:0006479]	mitochondrion [GO:0005739]	lysine N-methyltransferase activity [GO:0016278]; protein-lysine N-methyltransferase activity [GO:0016279]	mitochondrion [GO:0005739]; lysine N-methyltransferase activity [GO:0016278]; protein-lysine N-methyltransferase activity [GO:0016279]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; peptidyl-lysine trimethylation [GO:0018023]; protein methylation [GO:0006479]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25023281, ECO:0000269|PubMed:28887308}.
A8MV65	reviewed	VGLL3_HUMAN	Transcription cofactor vestigial-like protein 3 (Vgl-3)	VGLL3	Homo sapiens (Human)	326	FUNCTION: May act as a specific coactivator for the mammalian TEFs. {ECO:0000250|UniProtKB:Q8N8G2}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]		nucleus [GO:0005634]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N8G2}.
A8MVW5	reviewed	HECA2_HUMAN	HEPACAM family member 2 (Mitotic kinetics regulator)	HEPACAM2 MIKI UNQ305/PRO346	Homo sapiens (Human)	462	FUNCTION: Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. {ECO:0000269|PubMed:22864114}.		cell division [GO:0051301]; centrosome cycle [GO:0007098]	centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; spindle [GO:0005819]		centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; cell division [GO:0051301]; centrosome cycle [GO:0007098]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19358830, ECO:0000269|PubMed:22864114}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19358830, ECO:0000269|PubMed:22864114}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19358830, ECO:0000269|PubMed:22864114}. Midbody {ECO:0000269|PubMed:22864114}. Note=In interphase, localizes to the Golgi apparatus. Localizes to centrosomes and spindles during prophase, prometaphase, and metaphase of mitosis, and to midbodies at telophase. Translocation to mitotic centrosomes is the result of poly-ADP-ribosylation (PARsylation). {ECO:0000269|PubMed:19358830, ECO:0000269|PubMed:22864114}.
A8MW92	reviewed	P20L1_HUMAN	PHD finger protein 20-like protein 1	PHF20L1 CGI-72	Homo sapiens (Human)	1017	FUNCTION: Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed:24492612, PubMed:29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity). {ECO:0000250|UniProtKB:Q8CCJ9, ECO:0000269|PubMed:24492612, ECO:0000269|PubMed:29358331}.		negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein catabolic process [GO:0042177]; regulation of transcription by RNA polymerase II [GO:0006357]	NSL complex [GO:0044545]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; methylation-dependent protein binding [GO:0140034]	NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; methylation-dependent protein binding [GO:0140034]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein catabolic process [GO:0042177]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24492612}. Note=Localized to the perinucleolar region. {ECO:0000269|PubMed:24492612}.
A8MW95	reviewed	BECN2_HUMAN	Beclin-2 (Beclin-1 autophagy-related pseudogene 1) (Beclin-1-like protein 1)	BECN2 BECN1L1 BECN1P1	Homo sapiens (Human)	431	FUNCTION: Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1. {ECO:0000269|PubMed:23954414}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cellular response to nitrogen starvation [GO:0006995]; endosome to lysosome transport [GO:0008333]; G protein-coupled receptor catabolic process [GO:1990172]; glucose homeostasis [GO:0042593]; late endosome to vacuole transport [GO:0045324]	phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]	protein-containing complex binding [GO:0044877]	phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]; protein-containing complex binding [GO:0044877]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cellular response to nitrogen starvation [GO:0006995]; endosome to lysosome transport [GO:0008333]; G protein-coupled receptor catabolic process [GO:1990172]; glucose homeostasis [GO:0042593]; late endosome to vacuole transport [GO:0045324]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
A8MW99	reviewed	MEI4_HUMAN	Meiosis-specific protein MEI4	MEI4	Homo sapiens (Human)	385	FUNCTION: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. {ECO:0000250|UniProtKB:Q8BRM6}.		DNA recombination [GO:0006310]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break formation [GO:0042138]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]	lateral element [GO:0000800]		lateral element [GO:0000800]; DNA recombination [GO:0006310]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break formation [GO:0042138]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q8BRM6}. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis. Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema, decreases at zygonema and is strongly reduced in pachynema and subsequent stages. {ECO:0000250|UniProtKB:Q8BRM6}.
A8MXD5	reviewed	GRCR1_HUMAN	Glutaredoxin domain-containing cysteine-rich protein 1	GRXCR1 DFNB25	Homo sapiens (Human)	290	FUNCTION: May play a role in actin filament architecture in developing stereocilia of sensory cells. {ECO:0000250}.		inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell development [GO:0060119]; inner ear receptor cell stereocilium organization [GO:0060122]; post-embryonic animal organ morphogenesis [GO:0048563]; sensory perception of sound [GO:0007605]; vestibular receptor cell development [GO:0060118]	kinocilium [GO:0060091]; microvillus [GO:0005902]; stereocilium [GO:0032420]		kinocilium [GO:0060091]; microvillus [GO:0005902]; stereocilium [GO:0032420]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell development [GO:0060119]; inner ear receptor cell stereocilium organization [GO:0060122]; post-embryonic animal organ morphogenesis [GO:0048563]; sensory perception of sound [GO:0007605]; vestibular receptor cell development [GO:0060118]	SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000250}. Cell projection, microvillus {ECO:0000250}. Cell projection, kinocilium {ECO:0000250}. Note=In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia. {ECO:0000250}.
A8MXV4	reviewed	NUD19_HUMAN	Acyl-coenzyme A diphosphatase NUDT19 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 19) (Nudix motif 19)	NUDT19	Homo sapiens (Human)	375	FUNCTION: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity). Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). {ECO:0000250|UniProtKB:P11930}.		butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; fatty acid catabolic process [GO:0009062]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; propionyl-CoA metabolic process [GO:1902858]; succinyl-CoA catabolic process [GO:1901289]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]	acyl-coenzyme A diphosphatase activity [GO:0106399]; CoA pyrophosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; acyl-coenzyme A diphosphatase activity [GO:0106399]; CoA pyrophosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287]; butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; fatty acid catabolic process [GO:0009062]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; propionyl-CoA metabolic process [GO:1902858]; succinyl-CoA catabolic process [GO:1901289]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:P11930}.
A8MYU2	reviewed	KCNU1_HUMAN	Potassium channel subfamily U member 1 (Calcium-activated potassium channel subunit alpha-3) (Calcium-activated potassium channel, subfamily M subunit alpha-3) (KCa5) (Slowpoke homolog 3)	KCNU1 KCNMA3 KCNMC1 SLO3	Homo sapiens (Human)	1149	FUNCTION: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. {ECO:0000269|PubMed:23129643, ECO:0000269|PubMed:34980136, ECO:0000269|PubMed:35551387}.		potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]; reproductive process [GO:0022414]	membrane [GO:0016020]; plasma membrane [GO:0005886]	potassium channel activity [GO:0005267]; voltage-gated monoatomic ion channel activity [GO:0005244]	membrane [GO:0016020]; plasma membrane [GO:0005886]; potassium channel activity [GO:0005267]; voltage-gated monoatomic ion channel activity [GO:0005244]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]; reproductive process [GO:0022414]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O54982}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O54982}.
A8MZ59	reviewed	LEUTX_HUMAN	Paired-like homeodomain transcription factor LEUTX (Leucine-twenty homeobox) (Paired-like homeobox transcription factor LEUTX) (PRD-LIKE homeobox transcription factor LEUTX)	LEUTX	Homo sapiens (Human)	198	FUNCTION: [Isoform 1]: Paired-like homeobox transcription factor involved in embryogenesis (PubMed:27578796, PubMed:30479355). May act as a regulator of embryo genome activation (PubMed:27578796). Binds to a 36 bp DNA elements containing a 5'-TAATCC-3' sequence motif, referred to as EEA motif (EGA-enriched Alu-motif), present in the promoters of target genes activated in early embryos (PubMed:27578796, PubMed:30479355). {ECO:0000269|PubMed:27578796, ECO:0000269|PubMed:30479355}.; FUNCTION: [Isoform 2]: Inactive transcriptional activity. {ECO:0000269|PubMed:27578796}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27578796}.
A8TX70	reviewed	CO6A5_HUMAN	Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4)	COL6A5 COL29A1 VWA4	Homo sapiens (Human)	2615	FUNCTION: Collagen VI acts as a cell-binding protein. {ECO:0000250}.		cell adhesion [GO:0007155]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Deposed in the extracellular matrix of skeletal muscle. {ECO:0000250}.
A9QM74	reviewed	IMA8_HUMAN	Importin subunit alpha-8 (Karyopherin subunit alpha-7)	KPNA7	Homo sapiens (Human)	516	FUNCTION: Functions in nuclear protein import. {ECO:0000269|PubMed:36647821}.		blastocyst development [GO:0001824]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of gene expression [GO:0010629]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of gene expression [GO:0010628]; protein import into nucleus [GO:0006606]	cytosol [GO:0005829]; female germ cell nucleus [GO:0001674]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]	cytosol [GO:0005829]; female germ cell nucleus [GO:0001674]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; blastocyst development [GO:0001824]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of gene expression [GO:0010629]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of gene expression [GO:0010628]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20701745, ECO:0000269|PubMed:36647821}.
A9UHW6	reviewed	MI4GD_HUMAN	MIF4G domain-containing protein (SLBP-interacting protein 1) (hSLIP1)	MIF4GD SLIP1	Homo sapiens (Human)	222	FUNCTION: Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation. {ECO:0000269|PubMed:18025107}.	MISCELLANEOUS: Depletion of MIF4GD results in cell death and reduced histone mRNA translation.	cap-dependent translational initiation [GO:0002191]; regulation of translational initiation [GO:0006446]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone mRNA stem-loop binding complex [GO:0062073]; nucleolus [GO:0005730]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone mRNA stem-loop binding complex [GO:0062073]; nucleolus [GO:0005730]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]; cap-dependent translational initiation [GO:0002191]; regulation of translational initiation [GO:0006446]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18025107}. Nucleus {ECO:0000269|PubMed:18025107}.
A9YTQ3	reviewed	AHRR_HUMAN	Aryl hydrocarbon receptor repressor (AhR repressor) (AhRR) (Class E basic helix-loop-helix protein 77) (bHLHe77)	AHRR BHLHE77 KIAA1234	Homo sapiens (Human)	701	FUNCTION: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269|PubMed:17890447, ECO:0000269|PubMed:18172554}.			aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983]; transcription cis-regulatory region binding [GO:0000976]	aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983]; transcription cis-regulatory region binding [GO:0000976]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17980155}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:17980155}. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
B0I1T2	reviewed	MYO1G_HUMAN	Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)]	MYO1G HA2	Homo sapiens (Human)	1018	FUNCTION: Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}.		actin filament organization [GO:0007015]; cell gliding [GO:0071976]; cell-substrate adhesion [GO:0031589]; exocytosis [GO:0006887]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; T cell meandering migration [GO:0120117]; T cell mediated immunity [GO:0002456]; T cell migration [GO:0072678]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; microvillus [GO:0005902]; myosin complex [GO:0016459]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; microvillus [GO:0005902]; myosin complex [GO:0016459]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; actin filament organization [GO:0007015]; cell gliding [GO:0071976]; cell-substrate adhesion [GO:0031589]; exocytosis [GO:0006887]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; T cell meandering migration [GO:0120117]; T cell mediated immunity [GO:0002456]; T cell migration [GO:0072678]; vesicle transport along actin filament [GO:0030050]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19968988, ECO:0000269|PubMed:20071333}; Peripheral membrane protein {ECO:0000269|PubMed:19968988, ECO:0000269|PubMed:20071333}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q5SUA5}. Note=Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup. In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membranes are deformed (By similarity). Localization at the membrane is not highly dependent on phosphatidylinositol 4,5-bisphosphate levels. Released from the membrane in the presence of ATP. May be enriched in peripheral processes, such as microvilli or ruffles. {ECO:0000250|UniProtKB:Q5SUA5, ECO:0000269|PubMed:20071333}.
B0L3A2	reviewed	DESPR_HUMAN	Dual endothelin-1/VEGF signal peptide receptor (DEspR protein) (Dual endothelin-1/VEGFsp receptor) (FBXW7 antisense RNA 1)	FBXW7-AS1 DEAR DEspR	Homo sapiens (Human)	85	FUNCTION: Dual receptor for both endothelin-1 and the signal sequence of vascular endothelial growth factor A (PubMed:17446437, PubMed:24465725). Does not act as a receptor for angiotensin-2 (PubMed:17446437). Does not bind the VEGFA mature protein (By similarity). May play a role in angiogenesis with a significant role in cardiovascular and neural development (By similarity). {ECO:0000250|UniProtKB:Q2QKR2, ECO:0000269|PubMed:17446437, ECO:0000269|PubMed:24465725}.		endothelin receptor signaling pathway [GO:0086100]; vascular endothelial growth factor signaling pathway [GO:0038084]	plasma membrane [GO:0005886]	endothelin receptor activity [GO:0004962]; vascular endothelial growth factor binding [GO:0038085]	plasma membrane [GO:0005886]; endothelin receptor activity [GO:0004962]; vascular endothelial growth factor binding [GO:0038085]; endothelin receptor signaling pathway [GO:0086100]; vascular endothelial growth factor signaling pathway [GO:0038084]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24465725, ECO:0000269|PubMed:27301377, ECO:0000269|PubMed:33853558}; Single-pass membrane protein {ECO:0000305|PubMed:27301377}.
B0YJ81	reviewed	HACD1_HUMAN	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 1) (HACD1) (Cementum-attachment protein) (CAP) (Protein-tyrosine phosphatase-like member A)	HACD1 PTPLA	Homo sapiens (Human)	288	FUNCTION: [Isoform 1]: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.; FUNCTION: [Isoform 2]: In tooth development, may play a role in the recruitment and the differentiation of cells that contribute to cementum formation. May also bind hydroxyapatite and regulate its crystal nucleation to form cementum. {ECO:0000269|PubMed:22067203}.	MISCELLANEOUS: [Isoform 2]: Catalytically inactive since it lacks the active site but may have an alternative function. {ECO:0000269|PubMed:22067203}.	cementum mineralization [GO:0071529]; fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cell-substrate adhesion [GO:0010811]; protein-containing complex assembly [GO:0065003]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; hydroxyapatite binding [GO:0046848]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; hydroxyapatite binding [GO:0046848]; cementum mineralization [GO:0071529]; fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cell-substrate adhesion [GO:0010811]; protein-containing complex assembly [GO:0065003]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}.
B1AK53	reviewed	ESPN_HUMAN	Espin (Autosomal recessive deafness type 36 protein) (Ectoplasmic specialization protein)	ESPN DFNB36 LP2654	Homo sapiens (Human)	854	FUNCTION: Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:29572253). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (By similarity). Involved in the elongation of actin in stereocilia (PubMed:29572253). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation. {ECO:0000250|UniProtKB:Q9ET47, ECO:0000269|PubMed:29572253}.		actin filament bundle assembly [GO:0051017]; microvillar actin bundle assembly [GO:0030034]; sensory perception of sound [GO:0007605]	brush border [GO:0005903]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; microvillus [GO:0005902]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]	actin filament binding [GO:0051015]; SH3 domain binding [GO:0017124]	brush border [GO:0005903]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; microvillus [GO:0005902]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; actin filament binding [GO:0051015]; SH3 domain binding [GO:0017124]; actin filament bundle assembly [GO:0051017]; microvillar actin bundle assembly [GO:0030034]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9ET47}. Cell projection, stereocilium {ECO:0000269|PubMed:29572253}. Cell projection, microvillus {ECO:0000269|PubMed:29572253}.
B2RTY4	reviewed	MYO9A_HUMAN	Unconventional myosin-IXa (Unconventional myosin-9a)	MYO9A MYR7	Homo sapiens (Human)	2548	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}.	MISCELLANEOUS: [Isoform 5]: Lacks the ATP-binding domain which suggests that it cannot interact with actin. {ECO:0000305}.	cell junction assembly [GO:0034329]; establishment of epithelial cell apical/basal polarity [GO:0045198]; intracellular signal transduction [GO:0035556]; regulation of neuron projection arborization [GO:0150011]; regulation of small GTPase mediated signal transduction [GO:0051056]; visual perception [GO:0007601]	actin filament [GO:0005884]; axonal growth cone [GO:0044295]; cytosol [GO:0005829]; membrane [GO:0016020]; synapse [GO:0045202]; unconventional myosin complex [GO:0016461]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146]	actin filament [GO:0005884]; axonal growth cone [GO:0044295]; cytosol [GO:0005829]; membrane [GO:0016020]; synapse [GO:0045202]; unconventional myosin complex [GO:0016461]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146]; cell junction assembly [GO:0034329]; establishment of epithelial cell apical/basal polarity [GO:0045198]; intracellular signal transduction [GO:0035556]; regulation of neuron projection arborization [GO:0150011]; regulation of small GTPase mediated signal transduction [GO:0051056]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z1N3}. Synapse {ECO:0000250|UniProtKB:Q8C170}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q8C170}. Note=Localized in the cytoplasm of cell bodies, dendrites and axons with occasional hints of an enrichment near the plasma membrane. Localized at the neuromuscular junction (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}.
B2RUY7	reviewed	VWC2L_HUMAN	von Willebrand factor C domain-containing protein 2-like (VWC2-like protein) (Brorin-like)	VWC2L	Homo sapiens (Human)	222	FUNCTION: May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization. {ECO:0000250}.		negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of neuron differentiation [GO:0045666]	AMPA glutamate receptor complex [GO:0032281]; extracellular space [GO:0005615]; synapse [GO:0045202]		AMPA glutamate receptor complex [GO:0032281]; extracellular space [GO:0005615]; synapse [GO:0045202]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of neuron differentiation [GO:0045666]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Synapse {ECO:0000250}.
B2RUZ4	reviewed	SMIM1_HUMAN	Small integral membrane protein 1 (Vel blood group antigen)	SMIM1	Homo sapiens (Human)	78	FUNCTION: Regulator of red blood cell formation. {ECO:0000250|UniProtKB:B3DHH5}.			cell surface [GO:0009986]; plasma membrane [GO:0005886]	protein homodimerization activity [GO:0042803]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26452714}; Single-pass type II membrane protein {ECO:0000269|PubMed:26452714}.
B2RXF5	reviewed	ZBT42_HUMAN	Zinc finger and BTB domain-containing protein 42	ZBTB42	Homo sapiens (Human)	422	FUNCTION: Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. {ECO:0000250|UniProtKB:Q811H0}.		muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q811H0}. Nucleus {ECO:0000269|PubMed:21193930}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q811H0}. Note=In skeletal myofibers, highly enriched in subsynaptic nuclei at the neuromuscular junctions. {ECO:0000250|UniProtKB:Q811H0}.
B2RXH2	reviewed	KDM4E_HUMAN	Lysine-specific demethylase 4E (EC 1.14.11.66) (KDM4D-like protein) (Lysine-specific demethylase 4D-like) ([histone H3]-trimethyl-L-lysine(9) demethylase 4E)	KDM4E KDM4DL	Homo sapiens (Human)	506	FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. {ECO:0000269|PubMed:21914792}.		chromatin remodeling [GO:0006338]; regulation of gene expression [GO:0010468]	chromatin [GO:0000785]; nucleus [GO:0005634]	histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; metal ion binding [GO:0046872]	chromatin [GO:0000785]; nucleus [GO:0005634]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; metal ion binding [GO:0046872]; chromatin remodeling [GO:0006338]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
B3KU38	reviewed	IQIP1_HUMAN	IQCJ-SCHIP1 readthrough transcript protein	IQCJ-SCHIP1	Homo sapiens (Human)	563	FUNCTION: May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943). May also play a role in axon outgrowth and guidance (By similarity). {ECO:0000250|UniProtKB:A0A088MLT8, ECO:0000269|PubMed:25950943}.	MISCELLANEOUS: [Isoform IQCJ-SCHIP1-1]: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein. {ECO:0000269|PubMed:17045569}.; MISCELLANEOUS: [Isoform IQCJ-SCHIP1-2]: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein. {ECO:0000269|PubMed:17045569}.	negative regulation of cytoskeleton organization [GO:0051494]; positive regulation of hippo signaling [GO:0035332]	axon initial segment [GO:0043194]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]		axon initial segment [GO:0043194]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; negative regulation of cytoskeleton organization [GO:0051494]; positive regulation of hippo signaling [GO:0035332]	SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000250|UniProtKB:A0A088MLT8}. Cytoplasm {ECO:0000269|PubMed:17045569}. Note=Localizes to the axon initial segments (AIS) and nodes of Ranvier of neurons and is absent from dendrites. {ECO:0000250|UniProtKB:A0A088MLT8}.
B6A8C7	reviewed	TARM1_HUMAN	T-cell-interacting, activating receptor on myeloid cells protein 1 (OSCAR-like transcript-2 protein) (OLT-2)	TARM1	Homo sapiens (Human)	271	FUNCTION: May act as receptor (By similarity). Negatively regulates TCR-mediated CD4(+) T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface (PubMed:26311901). Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils (By similarity). {ECO:0000250|UniProtKB:B6A8R8, ECO:0000269|PubMed:26311901}.		adaptive immune response [GO:0002250]; innate immune response [GO:0045087]; negative regulation of CD4-positive, alpha-beta T cell activation [GO:2000515]	plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	immunoglobulin receptor binding [GO:0034987]	plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; immunoglobulin receptor binding [GO:0034987]; adaptive immune response [GO:0002250]; innate immune response [GO:0045087]; negative regulation of CD4-positive, alpha-beta T cell activation [GO:2000515]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26311901}; Single-pass type I membrane protein {ECO:0000305}.
B7U540	reviewed	KCJ18_HUMAN	Inward rectifier potassium channel 18 (Inward rectifier K(+) channel Kir2.6) (Potassium channel, inwardly rectifying subfamily J member 18)	KCNJ18	Homo sapiens (Human)	433	FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000269|PubMed:20074522, ECO:0000269|PubMed:27008341}.		potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765]	plasma membrane [GO:0005886]	inward rectifier potassium channel activity [GO:0005242]	plasma membrane [GO:0005886]; inward rectifier potassium channel activity [GO:0005242]; potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21665951}; Multi-pass membrane protein {ECO:0000255}.
B7ZAQ6	reviewed	GPHRA_HUMAN	Golgi pH regulator A (Protein GPR89A) (Putative MAPK-activating protein PM01) (Putative NF-kappa-B-activating protein 90)	GPR89A GPHRA GPR89 SH120 CGI-13 UNQ192/PRO218	Homo sapiens (Human)	455	FUNCTION: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (PubMed:12761501, PubMed:18794847). Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:Q8BS95, ECO:0000269|PubMed:12761501, ECO:0000269|PubMed:18794847}.	MISCELLANEOUS: Does not seem to be able to bind GTP.	intracellular pH reduction [GO:0051452]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein transport [GO:0015031]; regulation of monoatomic ion transmembrane transport [GO:0034765]; T cell differentiation [GO:0030217]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]	voltage-gated monoatomic anion channel activity [GO:0008308]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; voltage-gated monoatomic anion channel activity [GO:0008308]; intracellular pH reduction [GO:0051452]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein transport [GO:0015031]; regulation of monoatomic ion transmembrane transport [GO:0034765]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:B2ZXD5}; Multi-pass membrane protein {ECO:0000255}.
C4AMC7	reviewed	WASH3_HUMAN	Putative WAS protein family homolog 3 (Protein FAM39DP)	WASH3P FAM39DP	Homo sapiens (Human)	463	FUNCTION: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}.	MISCELLANEOUS: WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units. Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene. {ECO:0000305|PubMed:18159949}.	Arp2/3 complex-mediated actin nucleation [GO:0034314]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; exocytosis [GO:0006887]; protein targeting to lysosome [GO:0006622]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]	autophagosome [GO:0005776]; centriole [GO:0005814]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]	autophagosome [GO:0005776]; centriole [GO:0005814]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; exocytosis [GO:0006887]; protein targeting to lysosome [GO:0006622]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:20175130, ECO:0000269|PubMed:20498093}. Early endosome membrane {ECO:0000250|UniProtKB:A8K0Z3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8VDD8}. Cell projection, lamellipodium {ECO:0000269|PubMed:18159949}. Cell projection, filopodium {ECO:0000269|PubMed:18159949}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q8VDD8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8VDD8}. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2. Localizes to MMP14-positive late endosomes and transiently to invadipodia (By similarity). Localized to Salmonella typhimurium entry sites (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8}.
C9JE40	reviewed	PATL2_HUMAN	Protein PAT1 homolog 2 (PAT1-like protein 2) (Protein PAT1 homolog a) (Pat1a) (hPat1a)	PATL2	Homo sapiens (Human)	543	FUNCTION: RNA-binding protein that acts as a translational repressor. {ECO:0000250|UniProtKB:Q4V7K4}.		deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; negative regulation of cytoplasmic mRNA processing body assembly [GO:0010607]; negative regulation of translation [GO:0017148]; P-body assembly [GO:0033962]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; RNA binding [GO:0003723]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; negative regulation of cytoplasmic mRNA processing body assembly [GO:0010607]; negative regulation of translation [GO:0017148]; P-body assembly [GO:0033962]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:28965849}. Nucleus {ECO:0000250|UniProtKB:A2ARM1}.
C9JLW8	reviewed	MCRI1_HUMAN	Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B)	MCRIP1 FAM195B GRAN2	Homo sapiens (Human)	97	FUNCTION: The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771). {ECO:0000269|PubMed:25728771}.		regulation of epithelial to mesenchymal transition [GO:0010717]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; regulation of epithelial to mesenchymal transition [GO:0010717]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25728771, ECO:0000269|PubMed:26184334}. Cytoplasm, Stress granule {ECO:0000269|PubMed:26184334}.
C9JR72	reviewed	KBTBD_HUMAN	Kelch repeat and BTB domain-containing protein 13	KBTBD13	Homo sapiens (Human)	458	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. {ECO:0000269|PubMed:22542517}.		actin filament organization [GO:0007015]; protein ubiquitination [GO:0016567]; regulation of the force of skeletal muscle contraction [GO:0014728]; relaxation of skeletal muscle [GO:0090076]	cytosol [GO:0005829]	actin filament binding [GO:0051015]	cytosol [GO:0005829]; actin filament binding [GO:0051015]; actin filament organization [GO:0007015]; protein ubiquitination [GO:0016567]; regulation of the force of skeletal muscle contraction [GO:0014728]; relaxation of skeletal muscle [GO:0090076]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21109227, ECO:0000269|PubMed:22542517}.
C9JRZ8	reviewed	AK1BF_HUMAN	Aldo-keto reductase family 1 member B15 (EC 1.1.1.-) (EC 1.1.1.300) (EC 1.1.1.54) (Estradiol 17-beta-dehydrogenase AKR1B15) (Farnesol dehydrogenase) (EC 1.1.1.216) (Testosterone 17beta-dehydrogenase) (EC 1.1.1.64)	AKR1B15	Homo sapiens (Human)	316	FUNCTION: [Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:26222439, PubMed:21276782). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439). {ECO:0000269|PubMed:21276782, ECO:0000269|PubMed:25577493, ECO:0000269|PubMed:26222439}.; FUNCTION: [Isoform 2]: No oxidoreductase activity observed with the tested substrates. {ECO:0000269|PubMed:25577493}.	MISCELLANEOUS: Has no counterpart in murine species. {ECO:0000305}.	estrogen biosynthetic process [GO:0006703]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; allyl-alcohol dehydrogenase activity [GO:0047655]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; farnesol dehydrogenase activity [GO:0047886]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; allyl-alcohol dehydrogenase activity [GO:0047655]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; farnesol dehydrogenase activity [GO:0047886]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; estrogen biosynthetic process [GO:0006703]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:25577493}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:25577493}.
D3W0D1	reviewed	KLRF2_HUMAN	Killer cell lectin-like receptor subfamily F member 2 (Lectin-like receptor F2) (Activating coreceptor NKp65)	KLRF2	Homo sapiens (Human)	207	FUNCTION: C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A. {ECO:0000269|PubMed:20194751}.		natural killer cell degranulation [GO:0043320]; positive regulation of cytokine production [GO:0001819]	plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; protein homodimerization activity [GO:0042803]	plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; protein homodimerization activity [GO:0042803]; natural killer cell degranulation [GO:0043320]; positive regulation of cytokine production [GO:0001819]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20194751}; Single-pass type II membrane protein {ECO:0000269|PubMed:20194751}.
D6RGH6	reviewed	MCIN_HUMAN	Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas)	MCIDAS IDAS MCI MCIN	Homo sapiens (Human)	385	FUNCTION: Transcription regulator specifically required for multiciliate cell differentiation (PubMed:25048963). Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211). {ECO:0000250|UniProtKB:Q08B36, ECO:0000269|PubMed:21543332, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:25048963}.	MISCELLANEOUS: Was named Idas in reference to the cousin of the Gemini in ancient Greek mythology. {ECO:0000305|PubMed:21543332}.	cell cycle [GO:0007049]; centriole assembly [GO:0098534]; cilium assembly [GO:0060271]; motile cilium assembly [GO:0044458]; multi-ciliated epithelial cell differentiation [GO:1903251]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA replication [GO:0008156]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cilium assembly [GO:1902017]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of mitotic cell cycle [GO:0007346]	nuclear body [GO:0016604]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	nuclear body [GO:0016604]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; cell cycle [GO:0007049]; centriole assembly [GO:0098534]; cilium assembly [GO:0060271]; motile cilium assembly [GO:0044458]; multi-ciliated epithelial cell differentiation [GO:1903251]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA replication [GO:0008156]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cilium assembly [GO:1902017]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21543332, ECO:0000269|PubMed:25048963}. Note=Excluded from the nucleolus. {ECO:0000269|PubMed:21543332}.
E0CX11	reviewed	STMP1_HUMAN	Short transmembrane mitochondrial protein 1	STMP1 C7orf73	Homo sapiens (Human)	47	FUNCTION: Microprotein involved in mitochondrial respiratory chain complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV (mitochondrial cytochrome c oxidase complex) assembly (PubMed:35450818). Required for the formation of mitochondrial supercomplexes (SCs) (PubMed:35450818). Also required for the activation of the NLRP3 inflammasome (By similarity). {ECO:0000250|UniProtKB:P0DP99, ECO:0000269|PubMed:35450818}.		innate immune response [GO:0045087]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respirasome assembly [GO:0097250]; mitochondrial respiratory chain complex III assembly [GO:0034551]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; mitochondrial respirasome [GO:0005746]		mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; mitochondrial respirasome [GO:0005746]; innate immune response [GO:0045087]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respirasome assembly [GO:0097250]; mitochondrial respiratory chain complex III assembly [GO:0034551]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:35450818}; Single-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P0DP99}; Single-pass membrane protein {ECO:0000255}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P0DP99}.
F5H094	reviewed	SO1BT_HUMAN	SLCO1B3-SLCO1B7 readthrough transcript protein (Liver specific transporter-3 transmembrane 12) (LST-3TM12) (Organic anion transporting polypeptide 1B3-1B7) (OATP1B3-1B7) (Solute carrier organic anion transporter family member 1B3-1B7) (SLCO1B3-SLCO1B7)	SLCO1B3-SLCO1B7	Homo sapiens (Human)	687	FUNCTION: Mediates the Na(+)-independent uptake of organic anions (PubMed:29248594). Transports the conjugated steroids 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate) or E2G) and dehydroepiandrosterone 3-sulfate (DHEAS) at the smooth endoplasmic reticulum membrane (SER), granting access to metabolizing enzymes (PubMed:29248594, PubMed:31127008, PubMed:32818652). Contributes to the metabolism of bile acids such as taurocholate (cholyltaurine) and lithocholate, by functioning as a doorway between SER and cytosol, thereby decreasing their circulating levels and protecting the organism from their detergent properties (PubMed:31509437). Regulates access or exit of drugs to the SER lumen (PubMed:31127008). {ECO:0000269|PubMed:29248594, ECO:0000269|PubMed:31127008, ECO:0000269|PubMed:31509437, ECO:0000269|PubMed:32818652}.	MISCELLANEOUS: Based on a naturally occurring readthrough transcript which produces an SLCO1B3-SLCO1B7 fusion protein where the first five exons originate from SLCO1B3, while SLCO1B7 provides the remaining exons (PubMed:29248594). The resulting mRNA encodes for a functional transporter SLCO1B3-SLCO1B7 (PubMed:29248594). {ECO:0000269|PubMed:29248594}.	lipid transport [GO:0006869]	plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]	serine-type endopeptidase inhibitor activity [GO:0004867]; transmembrane transporter activity [GO:0022857]	plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; serine-type endopeptidase inhibitor activity [GO:0004867]; transmembrane transporter activity [GO:0022857]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Smooth endoplasmic reticulum membrane {ECO:0000269|PubMed:29248594}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU362056}. Cell membrane {ECO:0000269|PubMed:29248594, ECO:0000269|PubMed:32818652}; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:29248594}; Multi-pass membrane protein.
G2XKQ0	reviewed	SUMO5_HUMAN	Small ubiquitin-related modifier 5 (SUMO-5) (SUMO1 pseudogene 1) (Ubiquitin-like 2) (Ubiquitin-like 6)	SUMO1P1 SUMO5 UBL2 UBL6	Homo sapiens (Human)	101	FUNCTION: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Regulates the life cycle of promyelocytic leukemia nuclear bodies (PML-NBs). PolySUMO1P1/SUMO5 conjugation on 'Lys-160' of PML facilitates recruitment of PML-NB components, which enlarges PML-NB. SUMO1P1/SUMO5 also increases polySUMO2/3 conjugation of PML, resulting in RNF4-mediated disruption of PML-NBs. {ECO:0000269|PubMed:27211601}.	MISCELLANEOUS: Highly conserved among primate species, however is not detected in mice. {ECO:0000269|PubMed:27211601}.	PML body organization [GO:0030578]; protein sumoylation [GO:0016925]	nucleus [GO:0005634]	identical protein binding [GO:0042802]; protein tag activity [GO:0031386]; transcription factor binding [GO:0008134]; ubiquitin-like protein ligase binding [GO:0044389]	nucleus [GO:0005634]; identical protein binding [GO:0042802]; protein tag activity [GO:0031386]; transcription factor binding [GO:0008134]; ubiquitin-like protein ligase binding [GO:0044389]; PML body organization [GO:0030578]; protein sumoylation [GO:0016925]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27211601}. Note=Forms prominent non-membrane-bound structures in the nucleus. {ECO:0000269|PubMed:27211601}.
H0YL14	reviewed	TM250_HUMAN	Transmembrane protein 250 (Herpes virus UL25-binding protein)	TMEM250 C9orf69	Homo sapiens (Human)	139	FUNCTION: May play a role in cell proliferation by promoting progression into S phase. {ECO:0000269|PubMed:21667337}.; FUNCTION: (Microbial infection) Promotes human herpes simplex virus 1/HHV-1 proliferation. {ECO:0000269|PubMed:21667337}.		cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of viral process [GO:0048524]	cell division site [GO:0032153]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; septin complex [GO:0031105]; septin ring [GO:0005940]	GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]	cell division site [GO:0032153]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; septin complex [GO:0031105]; septin ring [GO:0005940]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of viral process [GO:0048524]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:21667337}. Cytoplasm {ECO:0000269|PubMed:21667337}. Note=Upon HHV-1 infection, accumulates arround the nuclear membrane and translocates into the nucleus.
H3BV60	reviewed	TGR3L_HUMAN	Transforming growth factor-beta receptor type 3-like protein (TGF-beta receptor type-3-like protein) (TGFR-3L) (Transforming growth factor-beta receptor type III-like protein) (TGF-beta receptor type III-like protein)	TGFBR3L	Homo sapiens (Human)	292	FUNCTION: Expressed in gonadotrope cells, acts as an inhibin B coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility. {ECO:0000269|PubMed:34910520}.		cell migration [GO:0016477]; epithelial to mesenchymal transition [GO:0001837]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transforming growth factor beta receptor signaling pathway [GO:0007179]	plasma membrane [GO:0005886]	glycosaminoglycan binding [GO:0005539]; transforming growth factor beta receptor activity [GO:0005024]; type II transforming growth factor beta receptor binding [GO:0005114]	plasma membrane [GO:0005886]; glycosaminoglycan binding [GO:0005539]; transforming growth factor beta receptor activity [GO:0005024]; type II transforming growth factor beta receptor binding [GO:0005114]; cell migration [GO:0016477]; epithelial to mesenchymal transition [GO:0001837]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33396509, ECO:0000269|PubMed:34910520}; Single-pass membrane protein {ECO:0000255}.
K7EJ46	reviewed	SIM22_HUMAN	Small integral membrane protein 22 (Cancer-associated small integral membrane open reading frame 1)	SMIM22 CASIMO1	Homo sapiens (Human)	83	FUNCTION: May modulate lipid droplet formation throught interaction with SQLE. {ECO:0000269|PubMed:29765154}.		lipid droplet formation [GO:0140042]; positive regulation of cell migration [GO:0030335]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]	late endosome [GO:0005770]; membrane [GO:0016020]		late endosome [GO:0005770]; membrane [GO:0016020]; lipid droplet formation [GO:0140042]; positive regulation of cell migration [GO:0030335]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Late endosome. Note=Partially colocalizedes with LAMP1 in late endosome. {ECO:0000269|PubMed:29765154}.
K9M1U5	reviewed	IFNL4_HUMAN	Interferon lambda-4 (IFN-lambda-4)	IFNL4	Homo sapiens (Human)	179	FUNCTION: Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes. {ECO:0000269|PubMed:23291588}.	MISCELLANEOUS: [Isoform 1]: Active form which is able to induce an antiviral response and prevent hepatitis C virus (HCV) replication in cell cultures.; MISCELLANEOUS: [Isoform 2]: Inactive form. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Inactive form unable to elicit an antiviral response. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Inactive form unable to elicit an antiviral response. {ECO:0000305}.	cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of immune response [GO:0050778]; type III interferon-mediated signaling pathway [GO:0038196]; tyrosine phosphorylation of STAT protein [GO:0007260]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of immune response [GO:0050778]; type III interferon-mediated signaling pathway [GO:0038196]; tyrosine phosphorylation of STAT protein [GO:0007260]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23291588}. Secreted {ECO:0000269|PubMed:23291588}.
L0R8F8	reviewed	MIDUO_HUMAN	Mitochondrial ribosome and complex I assembly factor AltMIEF1 (Alternative MIEF1 protein) (AltMIEF1) (MIEF1 microprotein) (MIEF1-MP) (alternative transcript upstream of MiD51) (AltMiD51)	MIEF1 AltMiD51 AltMIEF1	Homo sapiens (Human)	70	FUNCTION: Assembly factor involved in the biogenesis of the mitochondrial-specific ribosomes (mitoribosomes) (PubMed:30215512, PubMed:31666358, PubMed:28892042). Specifically associates with intermediates of the mitochondrial ribosome large subunit (mt-LSU) and is required for proper ribosome assembly, possibly preventing premature association of the large and small ribosomal subunits (PubMed:30215512, PubMed:31666358, PubMed:28892042). Thereby, indirectly regulates mitochondrial translation (PubMed:30215512, PubMed:31666358, PubMed:28892042). It is also required for complete assembly of the mitochondrial respiratory chain complex I (PubMed:31666358). May also function in DNM1L-mediated mitochondrial fission (PubMed:29083303). {ECO:0000269|PubMed:28892042, ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:30215512, ECO:0000269|PubMed:31666358}.	MISCELLANEOUS: [Isoform 3]: Product of an upstream open reading frame of the MIEF1 bicistronic gene. {ECO:0000305|PubMed:25621764}.	mitochondrial fission [GO:0000266]; mitochondrial large ribosomal subunit assembly [GO:1902775]; mitochondrial respiratory chain complex I assembly [GO:0032981]; positive regulation of mitochondrial translation [GO:0070131]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	mitochondrial large ribosomal subunit binding [GO:0140978]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; mitochondrial large ribosomal subunit binding [GO:0140978]; mitochondrial fission [GO:0000266]; mitochondrial large ribosomal subunit assembly [GO:1902775]; mitochondrial respiratory chain complex I assembly [GO:0032981]; positive regulation of mitochondrial translation [GO:0070131]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:28892042, ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:30215512}.
M0R2J8	reviewed	DCDC1_HUMAN	Doublecortin domain-containing protein 1 (Doublecortin domain-containing 5 protein)	DCDC1 DCDC5 KIAA1493	Homo sapiens (Human)	1783	FUNCTION: Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412). {ECO:0000269|PubMed:22159412}.		cell cycle [GO:0007049]; cell division [GO:0051301]; intracellular signal transduction [GO:0035556]; regulation of mitotic cytokinesis [GO:1902412]	cytoplasm [GO:0005737]; Flemming body [GO:0090543]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686]	carbohydrate binding [GO:0030246]; microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; Flemming body [GO:0090543]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; carbohydrate binding [GO:0030246]; microtubule binding [GO:0008017]; cell cycle [GO:0007049]; cell division [GO:0051301]; intracellular signal transduction [GO:0035556]; regulation of mitotic cytokinesis [GO:1902412]	SUBCELLULAR LOCATION: Midbody, Midbody ring {ECO:0000269|PubMed:22159412}. Midbody {ECO:0000269|PubMed:22159412}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:22159412}. Note=Associated with microtubules, in particular, with stabilized microtubules of the mitotic spindle during metaphase and with midbody microtubules during cytokinesis. {ECO:0000269|PubMed:22159412}.
O00115	reviewed	DNS2A_HUMAN	Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2)	DNASE2 DNASE2A DNL2	Homo sapiens (Human)	360	FUNCTION: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation (PubMed:29259162, PubMed:31775019). Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells (PubMed:29259162). {ECO:0000269|PubMed:29259162, ECO:0000269|PubMed:31775019}.		apoptotic DNA fragmentation [GO:0006309]; DNA metabolic process [GO:0006259]; enucleate erythrocyte differentiation [GO:0043353]; regulation of immune response [GO:0050776]	extracellular exosome [GO:0070062]; lysosome [GO:0005764]	deoxyribonuclease II activity [GO:0004531]; DNA binding [GO:0003677]	extracellular exosome [GO:0070062]; lysosome [GO:0005764]; deoxyribonuclease II activity [GO:0004531]; DNA binding [GO:0003677]; apoptotic DNA fragmentation [GO:0006309]; DNA metabolic process [GO:0006259]; enucleate erythrocyte differentiation [GO:0043353]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Lysosome.
O00116	reviewed	ADAS_HUMAN	Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase)	AGPS AAG5	Homo sapiens (Human)	658	FUNCTION: Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269|PubMed:8399344, ECO:0000269|PubMed:9553082}.		ether lipid biosynthetic process [GO:0008611]; lipid biosynthetic process [GO:0008610]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	alkylglycerone-phosphate synthase activity [GO:0008609]; FAD binding [GO:0071949]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; alkylglycerone-phosphate synthase activity [GO:0008609]; FAD binding [GO:0071949]; ether lipid biosynthetic process [GO:0008611]; lipid biosynthetic process [GO:0008610]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:P97275}. Peroxisome {ECO:0000250|UniProtKB:P97275}.
O00124	reviewed	UBXN8_HUMAN	UBX domain-containing protein 8 (Reproduction 8 protein) (Rep-8 protein) (UBX domain-containing protein 6)	UBXN8 D8S2298E REP8 UBXD6	Homo sapiens (Human)	270	FUNCTION: Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction. {ECO:0000269|PubMed:21949850}.		single fertilization [GO:0007338]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	protein-macromolecule adaptor activity [GO:0030674]; ubiquitin binding [GO:0043130]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin binding [GO:0043130]; single fertilization [GO:0007338]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21949850}; Multi-pass membrane protein {ECO:0000269|PubMed:21949850}.
O00139	reviewed	KIF2A_HUMAN	Kinesin-like protein KIF2A (Kinesin-2) (hK2)	KIF2A KIF2 KNS2	Homo sapiens (Human)	706	FUNCTION: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309}.	MISCELLANEOUS: HeLa cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles.	cell differentiation [GO:0030154]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; nervous system development [GO:0007399]; regulation of cell migration [GO:0030334]	centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; cell differentiation [GO:0030154]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; nervous system development [GO:0007399]; regulation of cell migration [GO:0030334]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.
O00141	reviewed	SGK1_HUMAN	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1)	SGK1 SGK	Homo sapiens (Human)	431	FUNCTION: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1. {ECO:0000269|PubMed:11154281, ECO:0000269|PubMed:11410590, ECO:0000269|PubMed:11696533, ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:12650886, ECO:0000269|PubMed:12761204, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:14623317, ECO:0000269|PubMed:14706641, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15044175, ECO:0000269|PubMed:15234985, ECO:0000269|PubMed:15319523, ECO:0000269|PubMed:15496163, ECO:0000269|PubMed:15733869, ECO:0000269|PubMed:15737648, ECO:0000269|PubMed:15845389, ECO:0000269|PubMed:15888551, ECO:0000269|PubMed:16036218, ECO:0000269|PubMed:16443776, ECO:0000269|PubMed:16982696, ECO:0000269|PubMed:17382906, ECO:0000269|PubMed:18005662, ECO:0000269|PubMed:18304449, ECO:0000269|PubMed:18753299, ECO:0000269|PubMed:19447520, ECO:0000269|PubMed:19756449, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:20730100, ECO:0000269|PubMed:21865597}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative promoter usage. {ECO:0000305}.	apoptotic process [GO:0006915]; cellular response to aldosterone [GO:1904045]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; neuron projection morphogenesis [GO:0048812]; positive regulation of transporter activity [GO:0032411]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of catalytic activity [GO:0050790]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of gastric acid secretion [GO:0060453]; regulation of signal transduction by p53 class mediator [GO:1901796]; renal sodium ion absorption [GO:0070294]; sodium ion transport [GO:0006814]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; chloride channel regulator activity [GO:0017081]; potassium channel regulator activity [GO:0015459]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; sodium channel regulator activity [GO:0017080]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; chloride channel regulator activity [GO:0017081]; potassium channel regulator activity [GO:0015459]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; sodium channel regulator activity [GO:0017080]; apoptotic process [GO:0006915]; cellular response to aldosterone [GO:1904045]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; neuron projection morphogenesis [GO:0048812]; positive regulation of transporter activity [GO:0032411]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of catalytic activity [GO:0050790]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of gastric acid secretion [GO:0060453]; regulation of signal transduction by p53 class mediator [GO:1901796]; renal sodium ion absorption [GO:0070294]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Cell membrane. Mitochondrion. Note=The subcellular localization is controlled by the cell cycle, as well as by exposure to specific hormones and environmental stress stimuli. In proliferating cells, it shuttles between the nucleus and cytoplasm in synchrony with the cell cycle, and in serum/growth factor-stimulated cells it resides in the nucleus. In contrast, after exposure to environmental stress or treatment with glucocorticoids, it is detected in the cytoplasm and with certain stress conditions is associated with the mitochondria. In osmoregulation through the epithelial sodium channel, it can be localized to the cytoplasmic surface of the cell membrane. Nuclear, upon phosphorylation.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane.
O00142	reviewed	KITM_HUMAN	Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (2'-deoxyuridine kinase TK2) (EC 2.7.1.74) (Deoxycytidine kinase TK2) (EC 2.7.1.-) (Mt-TK)	TK2	Homo sapiens (Human)	265	FUNCTION: Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix (PubMed:9989599, PubMed:11687801). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK (PubMed:9989599). Widely used as target of antiviral and chemotherapeutic agents (PubMed:9989599). {ECO:0000269|PubMed:11687801, ECO:0000269|PubMed:9989599}.		deoxycytidine metabolic process [GO:0046092]; DNA biosynthetic process [GO:0071897]; nucleobase-containing compound metabolic process [GO:0006139]; phosphorylation [GO:0016310]; pyrimidine nucleoside salvage [GO:0043097]; thymidine metabolic process [GO:0046104]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; deoxycytidine kinase activity [GO:0004137]; deoxynucleoside kinase activity [GO:0019136]; nucleoside kinase activity [GO:0019206]; thymidine kinase activity [GO:0004797]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; deoxycytidine kinase activity [GO:0004137]; deoxynucleoside kinase activity [GO:0019136]; nucleoside kinase activity [GO:0019206]; thymidine kinase activity [GO:0004797]; deoxycytidine metabolic process [GO:0046092]; DNA biosynthetic process [GO:0071897]; nucleobase-containing compound metabolic process [GO:0006139]; phosphorylation [GO:0016310]; pyrimidine nucleoside salvage [GO:0043097]; thymidine metabolic process [GO:0046104]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:9989599}.
O00144	reviewed	FZD9_HUMAN	Frizzled-9 (Fz-9) (hFz9) (FzE6) (CD antigen CD349)	FZD9 FZD3	Homo sapiens (Human)	591	FUNCTION: Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). {ECO:0000250|UniProtKB:Q8K4C8, ECO:0000250|UniProtKB:Q9R216, ECO:0000269|PubMed:27509850}.	MISCELLANEOUS: Authors show that FZD9 is responsible for the cellular phenotype found in neural progenitor cells (NPCs) derived from Williams syndrome patients namely increased apoptosis of neural progenitor cells (NPCs). {ECO:0000269|PubMed:27509850}.	B cell differentiation [GO:0030183]; bone regeneration [GO:1990523]; canonical Wnt signaling pathway [GO:0060070]; learning or memory [GO:0007611]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of necroptotic process [GO:0060546]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904394]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; non-canonical Wnt signaling pathway [GO:0035567]; ossification [GO:0001503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neural precursor cell proliferation [GO:2000179]; postsynapse organization [GO:0099173]; regulation of cell cycle [GO:0051726]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566]; regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904393]; release of cytochrome c from mitochondria [GO:0001836]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; filopodium membrane [GO:0031527]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	G protein-coupled receptor activity [GO:0004930]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; filopodium membrane [GO:0031527]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; G protein-coupled receptor activity [GO:0004930]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; B cell differentiation [GO:0030183]; bone regeneration [GO:1990523]; canonical Wnt signaling pathway [GO:0060070]; learning or memory [GO:0007611]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of necroptotic process [GO:0060546]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904394]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; non-canonical Wnt signaling pathway [GO:0035567]; ossification [GO:0001503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neural precursor cell proliferation [GO:2000179]; postsynapse organization [GO:0099173]; regulation of cell cycle [GO:0051726]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566]; regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904393]; release of cytochrome c from mitochondria [GO:0001836]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9R216}; Multi-pass membrane protein {ECO:0000255}. Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. {ECO:0000250|UniProtKB:Q8K4C8}.
O00148	reviewed	DX39A_HUMAN	ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49)	DDX39A DDX39	Homo sapiens (Human)	427	FUNCTION: [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965}.	MISCELLANEOUS: [Isoform 2]: Probably devoid of RNA helicase activity. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Probably devoid of RNA helicase activity. {ECO:0000305}.	mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; RNA export from nucleus [GO:0006405]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; RNA export from nucleus [GO:0006405]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21859714}. Cytoplasm {ECO:0000269|PubMed:21859714}. Note=Can translocate to the cytoplasm in the presence of MX1.
O00151	reviewed	PDLI1_HUMAN	PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36)	PDLIM1 CLIM1 CLP36	Homo sapiens (Human)	329	FUNCTION: Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}.		actin cytoskeleton organization [GO:0030036]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; fibroblast migration [GO:0010761]; heart development [GO:0007507]; maintenance of cell polarity [GO:0030011]; muscle structure development [GO:0061061]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; stress fiber assembly [GO:0043149]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; stress fiber [GO:0001725]; transcription regulator complex [GO:0005667]; Z disc [GO:0030018]	actin binding [GO:0003779]; cadherin binding involved in cell-cell adhesion [GO:0098641]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; transcription coactivator activity [GO:0003713]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; stress fiber [GO:0001725]; transcription regulator complex [GO:0005667]; Z disc [GO:0030018]; actin binding [GO:0003779]; cadherin binding involved in cell-cell adhesion [GO:0098641]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; transcription coactivator activity [GO:0003713]; actin cytoskeleton organization [GO:0030036]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; fibroblast migration [GO:0010761]; heart development [GO:0007507]; maintenance of cell polarity [GO:0030011]; muscle structure development [GO:0061061]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; stress fiber assembly [GO:0043149]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10861853, ECO:0000269|PubMed:11110697}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10861853, ECO:0000269|PubMed:11110697}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:10861853}. Note=Associates with actin stress fibers. {ECO:0000269|PubMed:11110697}.
O00154	reviewed	BACH_HUMAN	Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (hBACH) (CTE-IIa) (CTE-II) (Long chain acyl-CoA thioester hydrolase)	ACOT7 BACH	Homo sapiens (Human)	380	FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10578051). Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:10578051). May play an important physiological function in brain (PubMed:10578051). {ECO:0000269|PubMed:10578051}.	MISCELLANEOUS: [Isoform 4]: Major isoform. {ECO:0000305}.	acyl-CoA metabolic process [GO:0006637]; coenzyme A biosynthetic process [GO:0015937]; long-chain fatty-acyl-CoA catabolic process [GO:0036116]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; palmitic acid biosynthetic process [GO:1900535]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	carboxylic ester hydrolase activity [GO:0052689]; fatty-acyl-CoA binding [GO:0000062]; long-chain fatty acyl-CoA binding [GO:0036042]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; carboxylic ester hydrolase activity [GO:0052689]; fatty-acyl-CoA binding [GO:0000062]; long-chain fatty acyl-CoA binding [GO:0036042]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; protein homodimerization activity [GO:0042803]; acyl-CoA metabolic process [GO:0006637]; coenzyme A biosynthetic process [GO:0015937]; long-chain fatty-acyl-CoA catabolic process [GO:0036116]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; palmitic acid biosynthetic process [GO:1900535]	SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm, cytosol {ECO:0000305|PubMed:12435388}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm, cytosol {ECO:0000305|PubMed:12435388}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:12435388}.; SUBCELLULAR LOCATION: [Isoform 5]: Mitochondrion {ECO:0000269|PubMed:12435388}.
O00155	reviewed	GPR25_HUMAN	Probable G-protein coupled receptor 25	GPR25	Homo sapiens (Human)	361	FUNCTION: Orphan receptor.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O00159	reviewed	MYO1C_HUMAN	Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)	MYO1C	Homo sapiens (Human)	1063	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}.; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. {ECO:0000250|UniProtKB:Q9WTI7}.		actin filament organization [GO:0007015]; cellular response to type II interferon [GO:0071346]; chromatin remodeling [GO:0006338]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration by vascular endothelial growth factor signaling pathway [GO:0038089]; positive regulation of cellular response to insulin stimulus [GO:1900078]; positive regulation of histone acetylation [GO:0035066]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; protein targeting to membrane [GO:0006612]; regulation of bicellular tight junction assembly [GO:2000810]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; B-WICH complex [GO:0110016]; basal plasma membrane [GO:0009925]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; membrane raft [GO:0045121]; microvillus [GO:0005902]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; stereocilium membrane [GO:0060171]; unconventional myosin complex [GO:0016461]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; B-WICH complex [GO:0110016]; basal plasma membrane [GO:0009925]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; membrane raft [GO:0045121]; microvillus [GO:0005902]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; stereocilium membrane [GO:0060171]; unconventional myosin complex [GO:0016461]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; actin filament organization [GO:0007015]; cellular response to type II interferon [GO:0071346]; chromatin remodeling [GO:0006338]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration by vascular endothelial growth factor signaling pathway [GO:0038089]; positive regulation of cellular response to insulin stimulus [GO:1900078]; positive regulation of histone acetylation [GO:0035066]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; protein targeting to membrane [GO:0006612]; regulation of bicellular tight junction assembly [GO:2000810]; vesicle transport along actin filament [GO:0030050]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22736583}. Nucleus {ECO:0000269|PubMed:22736583}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9WTI7}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q92002}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9WTI7}. Cell projection, ruffle membrane {ECO:0000269|PubMed:34380438}. Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane (By similarity). Colocalizes in adipocytes with GLUT4 at actin-based membranes (By similarity). Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane (By similarity). Localizes transiently at cell membrane to region known to be enriched in PIP2 (By similarity). Activation of phospholipase C results in its redistribution to the cytoplasm (By similarity). Colocalizes with RNA polymerase II (PubMed:22736583). Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription (PubMed:22736583). {ECO:0000250|UniProtKB:Q9WTI7, ECO:0000269|PubMed:22736583}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleoplasm {ECO:0000269|PubMed:16133118}. Nucleus, nucleolus {ECO:0000269|PubMed:16133118, ECO:0000269|PubMed:16877530}. Note=Colocalizes with RNA polymerase II in the nucleus (By similarity). Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC) (PubMed:16133118, PubMed:16877530). Accumulates strongly in DFC and GC during activation of transcription (PubMed:16133118). Colocalizes with transcription sites (By similarity). Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6 (PubMed:16877530). Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles (PubMed:16877530). Colocalizes with RPS6 at the nuclear pore level (PubMed:16877530). {ECO:0000250|UniProtKB:Q9WTI7, ECO:0000269|PubMed:16133118, ECO:0000269|PubMed:16877530}.
O00160	reviewed	MYO1F_HUMAN	Unconventional myosin-If (Myosin-Ie)	MYO1F	Homo sapiens (Human)	1098	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; unconventional myosin complex [GO:0016461]; vesicle [GO:0031982]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; unconventional myosin complex [GO:0016461]; vesicle [GO:0031982]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; actin filament organization [GO:0007015]; vesicle transport along actin filament [GO:0030050]	
O00161	reviewed	SNP23_HUMAN	Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23)	SNAP23	Homo sapiens (Human)	211	FUNCTION: Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.		exocytosis [GO:0006887]; histamine secretion by mast cell [GO:0002553]; membrane fusion [GO:0061025]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]; vesicle targeting [GO:0006903]	adherens junction [GO:0005912]; azurophil granule [GO:0042582]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201]; specific granule [GO:0042581]; specific granule membrane [GO:0035579]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [GO:0070032]; tertiary granule membrane [GO:0070821]	SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]	adherens junction [GO:0005912]; azurophil granule [GO:0042582]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201]; specific granule [GO:0042581]; specific granule membrane [GO:0035579]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [GO:0070032]; tertiary granule membrane [GO:0070821]; SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]; exocytosis [GO:0006887]; histamine secretion by mast cell [GO:0002553]; membrane fusion [GO:0061025]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]; vesicle targeting [GO:0006903]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Synapse, synaptosome. Note=Mainly localized to the plasma membrane.
O00165	reviewed	HAX1_HUMAN	HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1)	HAX1 HS1BP1	Homo sapiens (Human)	279	FUNCTION: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. {ECO:0000269|PubMed:15339924, ECO:0000269|PubMed:16857965, ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:18319618, ECO:0000269|PubMed:18971376, ECO:0000269|PubMed:26997484, ECO:0000269|PubMed:9058808}.		cellular response to cytokine stimulus [GO:0071345]; negative regulation of apoptotic process [GO:0043066]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin filament organization [GO:0110053]; regulation of actin filament polymerization [GO:0030833]; regulation of apoptotic process [GO:0042981]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of protein targeting to mitochondrion [GO:1903214]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; clathrin-coated vesicle [GO:0030136]; endoplasmic reticulum [GO:0005783]; lamellipodium [GO:0030027]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; P-body [GO:0000932]; sarcoplasmic reticulum [GO:0016529]; transcription regulator complex [GO:0005667]	interleukin-1 binding [GO:0019966]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; clathrin-coated vesicle [GO:0030136]; endoplasmic reticulum [GO:0005783]; lamellipodium [GO:0030027]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; P-body [GO:0000932]; sarcoplasmic reticulum [GO:0016529]; transcription regulator complex [GO:0005667]; interleukin-1 binding [GO:0019966]; cellular response to cytokine stimulus [GO:0071345]; negative regulation of apoptotic process [GO:0043066]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin filament organization [GO:0110053]; regulation of actin filament polymerization [GO:0030833]; regulation of apoptotic process [GO:0042981]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of protein targeting to mitochondrion [GO:1903214]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:18971376, ECO:0000269|PubMed:9058808}. Endoplasmic reticulum {ECO:0000269|PubMed:18971376, ECO:0000269|PubMed:9058808}. Nucleus membrane {ECO:0000269|PubMed:9058808}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O35387}. Cytoplasm, cell cortex {ECO:0000269|PubMed:26997484}. Cell membrane {ECO:0000269|PubMed:26997484}; Peripheral membrane protein {ECO:0000269|PubMed:26997484}; Cytoplasmic side {ECO:0000269|PubMed:26997484}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q7TSE9}. Cytoplasm, P-body {ECO:0000269|PubMed:23164465}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:23164465, ECO:0000269|PubMed:25298122}. Nucleus {ECO:0000269|PubMed:23164465}. Note=Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited, and in response to cellular stress caused by arsenite (in vitro). {ECO:0000269|PubMed:23164465}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:23164465}. Nucleus {ECO:0000269|PubMed:23164465}. Note=Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro). {ECO:0000269|PubMed:23164465}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:23164465}. Nucleus {ECO:0000269|PubMed:23164465}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000269|PubMed:23164465}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:23164465}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:23164465}.
O00167	reviewed	EYA2_HUMAN	Eyes absent homolog 2 (EC 3.1.3.48)	EYA2 EAB1	Homo sapiens (Human)	538	FUNCTION: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905). {ECO:0000269|PubMed:12500905, ECO:0000269|PubMed:19351884, ECO:0000269|PubMed:21706047, ECO:0000269|PubMed:23435380}.		anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; DNA repair [GO:0006281]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; mesodermal cell fate specification [GO:0007501]; mitochondrial outer membrane permeabilization [GO:0097345]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of DNA repair [GO:0045739]; striated muscle tissue development [GO:0014706]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone H2AXY142 phosphatase activity [GO:0140793]; magnesium ion binding [GO:0000287]; protein tyrosine phosphatase activity [GO:0004725]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone H2AXY142 phosphatase activity [GO:0140793]; magnesium ion binding [GO:0000287]; protein tyrosine phosphatase activity [GO:0004725]; anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; DNA repair [GO:0006281]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; mesodermal cell fate specification [GO:0007501]; mitochondrial outer membrane permeabilization [GO:0097345]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of DNA repair [GO:0045739]; striated muscle tissue development [GO:0014706]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10906137, ECO:0000269|PubMed:12500905}. Nucleus {ECO:0000269|PubMed:10906137, ECO:0000269|PubMed:12500905, ECO:0000269|PubMed:19497856}. Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2 (PubMed:10906137). Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus (PubMed:10906137, PubMed:12500905). {ECO:0000269|PubMed:10906137, ECO:0000269|PubMed:12500905}.
O00168	reviewed	PLM_HUMAN	Phospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1)	FXYD1 PLM	Homo sapiens (Human)	92	FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. {ECO:0000250|UniProtKB:O08589, ECO:0000250|UniProtKB:P56513, ECO:0000250|UniProtKB:Q9Z239}.		chloride transport [GO:0006821]; muscle contraction [GO:0006936]; negative regulation of protein glutathionylation [GO:0010734]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion transport [GO:0006813]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of heart contraction [GO:0008016]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; sodium ion transport [GO:0006814]	apical plasma membrane [GO:0016324]; caveola [GO:0005901]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; T-tubule [GO:0030315]	chloride channel activity [GO:0005254]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]	apical plasma membrane [GO:0016324]; caveola [GO:0005901]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; T-tubule [GO:0030315]; chloride channel activity [GO:0005254]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; chloride transport [GO:0006821]; muscle contraction [GO:0006936]; negative regulation of protein glutathionylation [GO:0010734]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion transport [GO:0006813]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of heart contraction [GO:0008016]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P56513}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O08589}; Single-pass type I membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:O08589}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08589}. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. {ECO:0000250|UniProtKB:O08589}.
O00170	reviewed	AIP_HUMAN	AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9)	AIP XAP2	Homo sapiens (Human)	330	FUNCTION: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein.		protein maturation by protein folding [GO:0022417]; protein targeting to mitochondrion [GO:0006626]; regulation of protein kinase A signaling [GO:0010738]; xenobiotic metabolic process [GO:0006805]	aryl hydrocarbon receptor complex [GO:0034751]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	aryl hydrocarbon receptor binding [GO:0017162]; GAF domain binding [GO:0036004]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; transcription coactivator activity [GO:0003713]; unfolded protein binding [GO:0051082]	aryl hydrocarbon receptor complex [GO:0034751]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; aryl hydrocarbon receptor binding [GO:0017162]; GAF domain binding [GO:0036004]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; transcription coactivator activity [GO:0003713]; unfolded protein binding [GO:0051082]; protein maturation by protein folding [GO:0022417]; protein targeting to mitochondrion [GO:0006626]; regulation of protein kinase A signaling [GO:0010738]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm.
O00175	reviewed	CCL24_HUMAN	C-C motif chemokine 24 (CK-beta-6) (Eosinophil chemotactic protein 2) (Eotaxin-2) (Myeloid progenitor inhibitory factor 2) (MPIF-2) (Small-inducible cytokine A24)	CCL24 MPIF2 SCYA24	Homo sapiens (Human)	119	FUNCTION: Chemotactic for resting T-lymphocytes, and eosinophils (PubMed:9104803, PubMed:9365122). Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes (PubMed:9104803, PubMed:9365122). Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line (PubMed:9104803, PubMed:9365122). Binds to CCR3 (PubMed:9104803, PubMed:9365122). {ECO:0000269|PubMed:9104803, ECO:0000269|PubMed:9365122}.		cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of eosinophil migration [GO:2000418]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of inflammatory response [GO:0050729]; regulation of cell shape [GO:0008360]; signal transduction [GO:0007165]	extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR3 chemokine receptor binding [GO:0031728]; chemokine activity [GO:0008009]; receptor ligand activity [GO:0048018]	extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR3 chemokine receptor binding [GO:0031728]; chemokine activity [GO:0008009]; receptor ligand activity [GO:0048018]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of eosinophil migration [GO:2000418]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of inflammatory response [GO:0050729]; regulation of cell shape [GO:0008360]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9104803, ECO:0000269|PubMed:9365122}.
O00180	reviewed	KCNK1_HUMAN	Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1)	KCNK1 HOHO1 KCNO1 TWIK1	Homo sapiens (Human)	336	FUNCTION: Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478). {ECO:0000250|UniProtKB:O08581, ECO:0000250|UniProtKB:Q9Z2T2, ECO:0000269|PubMed:15820677, ECO:0000269|PubMed:17693262, ECO:0000269|PubMed:19959478, ECO:0000269|PubMed:20498050, ECO:0000269|PubMed:21653227, ECO:0000269|PubMed:22282804, ECO:0000269|PubMed:22431633, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:25001086, ECO:0000269|PubMed:8605869, ECO:0000269|PubMed:8978667}.	MISCELLANEOUS: When the external K(+) concentration is lowered to subphysiological levels, it takes several minutes till the channel has reached a new, stable state characterized by increased Na(+) permeability (PubMed:21653227). Likewise, when the external pH is lowered to values below 6.5, it takes several minutes till the channel has reached a new, stable state characterized by increased Na(+) permeability (PubMed:22431633). When raising the K(+) concentration back to 5 mM, it takes 40 to 70 minutes for the channel to regain its original selectivity for K(+) (PubMed:21653227). Likewise, it takes more that 25 minutes for the channel to regain its original K(+) selectivity when the pH is raised back to 7.4 (PubMed:22431633). {ECO:0000269|PubMed:21653227, ECO:0000269|PubMed:22431633}.	potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of resting membrane potential [GO:0060075]; response to nicotine [GO:0035094]; sodium ion transmembrane transport [GO:0035725]; stabilization of membrane potential [GO:0030322]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; inward rectifier potassium channel complex [GO:1902937]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; recycling endosome [GO:0055037]; synaptic membrane [GO:0097060]; voltage-gated potassium channel complex [GO:0008076]	identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; sodium channel activity [GO:0005272]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; inward rectifier potassium channel complex [GO:1902937]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; recycling endosome [GO:0055037]; synaptic membrane [GO:0097060]; voltage-gated potassium channel complex [GO:0008076]; identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; sodium channel activity [GO:0005272]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of resting membrane potential [GO:0060075]; response to nicotine [GO:0035094]; sodium ion transmembrane transport [GO:0035725]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15820677, ECO:0000269|PubMed:17693262, ECO:0000269|PubMed:20498050, ECO:0000269|PubMed:21653227, ECO:0000269|PubMed:22282804, ECO:0000269|PubMed:22431633, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:25001086, ECO:0000269|PubMed:8605869, ECO:0000269|PubMed:8978667}; Multi-pass membrane protein {ECO:0000269|PubMed:22282804, ECO:0000269|PubMed:8978667, ECO:0000305}. Recycling endosome {ECO:0000269|PubMed:19959478}. Synaptic cell membrane {ECO:0000250|UniProtKB:Q9Z2T2}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O08581}. Perikaryon {ECO:0000250|UniProtKB:O08581}. Cell projection, dendrite {ECO:0000250|UniProtKB:O08581}. Cell projection {ECO:0000250|UniProtKB:O08581}. Apical cell membrane {ECO:0000269|PubMed:21964404}; Multi-pass membrane protein {ECO:0000305}. Note=The heterodimer with KCNK2 is detected at the astrocyte cell membrane. Not detected at the astrocyte cell membrane when KCNK2 is absent. Detected on neuronal cell bodies, and to a lesser degree on neuronal cell projections. Detected on hippocampus dentate gyrus granule cell bodies and to a lesser degree on proximal dendrites. Detected at the apical cell membrane in stria vascularis in the cochlea. Detected at the apical cell membrane of vestibular dark cells situated between the crista and the utricle in the inner ear. Detected at the apical cell membrane in kidney proximal tubule segment S1 and in subapical compartments in segments S1, S2 and S3. Predominantly in cytoplasmic structures in kidney distal convoluted tubules and collecting ducts (By similarity). Detected at the apical cell membrane of bronchial epithelial cells (PubMed:21964404). {ECO:0000250|UniProtKB:O08581, ECO:0000250|UniProtKB:Q9Z2T2, ECO:0000269|PubMed:21964404}.
O00182	reviewed	LEG9_HUMAN	Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21)	LGALS9	Homo sapiens (Human)	355	FUNCTION: Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:24465902, PubMed:16116184). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:25754930, PubMed:16116184). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity). {ECO:0000250|UniProtKB:O08573, ECO:0000250|UniProtKB:P97840, ECO:0000269|PubMed:16116184, ECO:0000269|PubMed:16286920, ECO:0000269|PubMed:18005988, ECO:0000269|PubMed:18977853, ECO:0000269|PubMed:20209097, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:23408620, ECO:0000269|PubMed:23817958, ECO:0000269|PubMed:24465902, ECO:0000269|PubMed:25578313, ECO:0000269|PubMed:25754930}.; FUNCTION: [Isoform 2]: Acts as an eosinophil chemoattractant (PubMed:9642261). It also inhibits angiogenesis (PubMed:24333696). Suppresses IFNG production by natural killer cells (By similarity). {ECO:0000250|UniProtKB:O08573, ECO:0000269|PubMed:24333696, ECO:0000269|PubMed:9642261}.		cellular response to type II interferon [GO:0071346]; cellular response to virus [GO:0098586]; chemotaxis [GO:0006935]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; inflammatory response [GO:0006954]; maternal process involved in female pregnancy [GO:0060135]; natural killer cell tolerance induction [GO:0002519]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of chemokine production [GO:0032682]; negative regulation of gene expression [GO:0010629]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; p38MAPK cascade [GO:0038066]; positive regulation of activated T cell autonomous cell death [GO:0070241]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [GO:0032834]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001190]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of viral entry into host cell [GO:0046598]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]	carbohydrate binding [GO:0030246]; disaccharide binding [GO:0048030]; enzyme binding [GO:0019899]; galactose binding [GO:0005534]; galactoside binding [GO:0016936]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; carbohydrate binding [GO:0030246]; disaccharide binding [GO:0048030]; enzyme binding [GO:0019899]; galactose binding [GO:0005534]; galactoside binding [GO:0016936]; cellular response to type II interferon [GO:0071346]; cellular response to virus [GO:0098586]; chemotaxis [GO:0006935]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; inflammatory response [GO:0006954]; maternal process involved in female pregnancy [GO:0060135]; natural killer cell tolerance induction [GO:0002519]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of chemokine production [GO:0032682]; negative regulation of gene expression [GO:0010629]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; p38MAPK cascade [GO:0038066]; positive regulation of activated T cell autonomous cell death [GO:0070241]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [GO:0032834]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001190]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of viral entry into host cell [GO:0046598]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23242525}. Nucleus {ECO:0000269|PubMed:23242525}. Secreted {ECO:0000269|PubMed:23817958, ECO:0000269|PubMed:25578313}. Note=May also be secreted by a non-classical secretory pathway (By similarity). Secreted by mesenchymal stromal cells upon IFNG stimulation (PubMed:23817958). {ECO:0000250|UniProtKB:O08573, ECO:0000269|PubMed:23817958}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:24333696}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:24333696}.
O00186	reviewed	STXB3_HUMAN	Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C)	STXBP3	Homo sapiens (Human)	592	FUNCTION: Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}.		brain development [GO:0007420]; cellular response to type II interferon [GO:0071346]; insulin secretion [GO:0030073]; intracellular glucose homeostasis [GO:0001678]; intracellular protein transport [GO:0006886]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of glucose import [GO:0046325]; neurotransmitter secretion [GO:0007269]; neutrophil degranulation [GO:0043312]; platelet aggregation [GO:0070527]; protein to membrane docking [GO:0022615]; response to insulin [GO:0032868]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; presynapse [GO:0098793]; secretory granule [GO:0030141]; specific granule [GO:0042581]; tertiary granule [GO:0070820]	protein-containing complex binding [GO:0044877]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; presynapse [GO:0098793]; secretory granule [GO:0030141]; specific granule [GO:0042581]; tertiary granule [GO:0070820]; protein-containing complex binding [GO:0044877]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]; brain development [GO:0007420]; cellular response to type II interferon [GO:0071346]; insulin secretion [GO:0030073]; intracellular glucose homeostasis [GO:0001678]; intracellular protein transport [GO:0006886]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of glucose import [GO:0046325]; neurotransmitter secretion [GO:0007269]; neutrophil degranulation [GO:0043312]; platelet aggregation [GO:0070527]; protein to membrane docking [GO:0022615]; response to insulin [GO:0032868]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10194441}. Cell membrane {ECO:0000269|PubMed:10194441}. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated.
O00187	reviewed	MASP2_HUMAN	Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]	MASP2	Homo sapiens (Human)	686	FUNCTION: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. {ECO:0000269|PubMed:10946292}.		complement activation, classical pathway [GO:0006958]; complement activation, lectin pathway [GO:0001867]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; complement component C4b binding [GO:0001855]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; complement component C4b binding [GO:0001855]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; complement activation, classical pathway [GO:0006958]; complement activation, lectin pathway [GO:0001867]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
O00189	reviewed	AP4M1_HUMAN	AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4)	AP4M1 MUARP2	Homo sapiens (Human)	453	FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10436028, PubMed:11139587, PubMed:10066790, PubMed:11802162, PubMed:20230749). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (PubMed:11139587, PubMed:20230749). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:26544806, PubMed:20230749). The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity). {ECO:0000250|UniProtKB:E2RED8, ECO:0000250|UniProtKB:Q2PWT8, ECO:0000250|UniProtKB:Q9JKC7, ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000269|PubMed:11139587, ECO:0000269|PubMed:11802162, ECO:0000269|PubMed:20230749, ECO:0000269|PubMed:26544806}.		autophagosome assembly [GO:0000045]; Golgi to endosome transport [GO:0006895]; Golgi to lysosome transport [GO:0090160]; intracellular protein transport [GO:0006886]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization [GO:0008104]; protein localization to basolateral plasma membrane [GO:1903361]; protein targeting [GO:0006605]; protein targeting to lysosome [GO:0006622]; vesicle-mediated transport [GO:0016192]	AP-4 adaptor complex [GO:0030124]; clathrin adaptor complex [GO:0030131]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome lumen [GO:0031904]; extracellular exosome [GO:0070062]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	protein domain specific binding [GO:0019904]; protein transmembrane transporter activity [GO:0008320]	AP-4 adaptor complex [GO:0030124]; clathrin adaptor complex [GO:0030131]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome lumen [GO:0031904]; extracellular exosome [GO:0070062]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; protein domain specific binding [GO:0019904]; protein transmembrane transporter activity [GO:0008320]; autophagosome assembly [GO:0000045]; Golgi to endosome transport [GO:0006895]; Golgi to lysosome transport [GO:0090160]; intracellular protein transport [GO:0006886]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization [GO:0008104]; protein localization to basolateral plasma membrane [GO:1903361]; protein targeting [GO:0006605]; protein targeting to lysosome [GO:0006622]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:20230749, ECO:0000269|PubMed:29180427, ECO:0000269|PubMed:32073997}; Peripheral membrane protein {ECO:0000305|PubMed:32073997}. Early endosome {ECO:0000269|PubMed:20230749}. Note=Found in soma and dendritic shafts of neuronal cells. {ECO:0000250|UniProtKB:Q2PWT8}.
O00192	reviewed	ARVC_HUMAN	Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome)	ARVCF	Homo sapiens (Human)	962	FUNCTION: Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}.		cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; messenger ribonucleoprotein complex [GO:1990124]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; messenger ribonucleoprotein complex [GO:1990124]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:10725230, ECO:0000269|PubMed:24644279, ECO:0000305|PubMed:30479852}. Nucleus {ECO:0000269|PubMed:10725230, ECO:0000269|PubMed:24644279}. Cytoplasm {ECO:0000269|PubMed:24644279}. Note=In heart, localizes at area composita, the mixed-type junctional structure composed of both desmosomal and adherens junctional proteins. {ECO:0000250|UniProtKB:B4F7F3}.
O00194	reviewed	RB27B_HUMAN	Ras-related protein Rab-27B (EC 3.6.5.2) (C25KG)	RAB27B	Homo sapiens (Human)	218	FUNCTION: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity). {ECO:0000250|UniProtKB:Q8HZJ5, ECO:0000269|PubMed:21775604, ECO:0000269|PubMed:30771381}.		anterograde axonal protein transport [GO:0099641]; exocytosis [GO:0006887]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exocytosis [GO:0045921]; synaptic vesicle endocytosis [GO:0048488]	apical plasma membrane [GO:0016324]; axon cytoplasm [GO:1904115]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; late endosome [GO:0005770]; melanosome [GO:0042470]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network transport vesicle [GO:0030140]; zymogen granule membrane [GO:0042589]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904]	apical plasma membrane [GO:0016324]; axon cytoplasm [GO:1904115]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; late endosome [GO:0005770]; melanosome [GO:0042470]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network transport vesicle [GO:0030140]; zymogen granule membrane [GO:0042589]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904]; anterograde axonal protein transport [GO:0099641]; exocytosis [GO:0006887]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exocytosis [GO:0045921]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Late endosome {ECO:0000269|PubMed:30771381}.
O00198	reviewed	HRK_HUMAN	Activator of apoptosis harakiri (BH3-interacting domain-containing protein 3) (Neuronal death protein DP5)	HRK BID3	Homo sapiens (Human)	91	FUNCTION: Promotes apoptosis. {ECO:0000269|PubMed:15031724, ECO:0000269|PubMed:9130713}.		apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]	membrane [GO:0016020]; mitochondrion [GO:0005739]		membrane [GO:0016020]; mitochondrion [GO:0005739]; apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]	SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein. Mitochondrion.
O00203	reviewed	AP3B1_HUMAN	AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain)	AP3B1 ADTB3A	Homo sapiens (Human)	1094	FUNCTION: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000305|PubMed:9151686}.		anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; establishment of protein localization to mitochondrial membrane involved in mitochondrial fission [GO:0090152]; granulocyte differentiation [GO:0030851]; hematopoietic progenitor cell differentiation [GO:0002244]; homeostasis of number of cells [GO:0048872]; inflammatory response [GO:0006954]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; intracellular zinc ion homeostasis [GO:0006882]; lung morphogenesis [GO:0060425]; lysosome organization [GO:0007040]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; mRNA transcription by RNA polymerase II [GO:0042789]; platelet dense granule organization [GO:0060155]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cell surface [GO:0034394]; protein modification process [GO:0036211]; protein targeting to lysosome [GO:0006622]; respiratory system process [GO:0003016]; single fertilization [GO:0007338]; skin epidermis development [GO:0098773]; spermatogenesis [GO:0007283]; toll-like receptor signaling pathway [GO:0002224]; vesicle-mediated transport [GO:0016192]	AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin adaptor complex [GO:0030131]; clathrin-coated vesicle membrane [GO:0030665]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrion [GO:0005739]	GTP-dependent protein binding [GO:0030742]; protein phosphatase binding [GO:0019903]	AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin adaptor complex [GO:0030131]; clathrin-coated vesicle membrane [GO:0030665]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrion [GO:0005739]; GTP-dependent protein binding [GO:0030742]; protein phosphatase binding [GO:0019903]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; establishment of protein localization to mitochondrial membrane involved in mitochondrial fission [GO:0090152]; granulocyte differentiation [GO:0030851]; hematopoietic progenitor cell differentiation [GO:0002244]; homeostasis of number of cells [GO:0048872]; inflammatory response [GO:0006954]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; intracellular zinc ion homeostasis [GO:0006882]; lung morphogenesis [GO:0060425]; lysosome organization [GO:0007040]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; mRNA transcription by RNA polymerase II [GO:0042789]; platelet dense granule organization [GO:0060155]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cell surface [GO:0034394]; protein modification process [GO:0036211]; protein targeting to lysosome [GO:0006622]; respiratory system process [GO:0003016]; single fertilization [GO:0007338]; skin epidermis development [GO:0098773]; spermatogenesis [GO:0007283]; toll-like receptor signaling pathway [GO:0002224]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000305|PubMed:9151686}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000305|PubMed:9151686}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000305|PubMed:9151686}.
O00204	reviewed	ST2B1_HUMAN	Sulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1)	SULT2B1 HSST2	Homo sapiens (Human)	365	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:19589875, PubMed:12145317). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:9799594, PubMed:12145317, PubMed:21855633, PubMed:16855051). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). {ECO:0000269|PubMed:12145317, ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:21855633, ECO:0000269|PubMed:28575648, ECO:0000269|PubMed:9799594}.; FUNCTION: [Isoform 2]: Sulfonates pregnenolone but not cholesterol. {ECO:0000269|PubMed:12145317}.		3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; cholesterol metabolic process [GO:0008203]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of epidermal cell differentiation [GO:0045606]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]	cholesterol binding [GO:0015485]; cholesterol sulfotransferase activity [GO:0051922]; nucleic acid binding [GO:0003676]; small molecule binding [GO:0036094]; steroid hormone binding [GO:1990239]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; cholesterol binding [GO:0015485]; cholesterol sulfotransferase activity [GO:0051922]; nucleic acid binding [GO:0003676]; small molecule binding [GO:0036094]; steroid hormone binding [GO:1990239]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; cholesterol metabolic process [GO:0008203]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of epidermal cell differentiation [GO:0045606]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12923182, ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:21855633, ECO:0000269|PubMed:28575648}. Microsome {ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:21855633}. Nucleus {ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:21855633}. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus. {ECO:0000269|PubMed:21855633}.
O00206	reviewed	TLR4_HUMAN	Toll-like receptor 4 (hToll) (CD antigen CD284)	TLR4	Homo sapiens (Human)	839	FUNCTION: Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways (PubMed:16622205, PubMed:10835634, PubMed:15809303, PubMed:17478729, PubMed:20037584, PubMed:20711192, PubMed:23880187, PubMed:27022195, PubMed:17292937, PubMed:29038465). At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+) (PubMed:20711192). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634, PubMed:27022195, PubMed:21393102). Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production (PubMed:14517278). In addition to the secretion of proinflammatory cytokines, initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-kappa-B signaling cascade (PubMed:32894580). In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86 (PubMed:23880187). Upon ligand binding, such as oxLDL or amyloid-beta 42, the TLR4:TLR6 complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway (PubMed:23880187). In myeloid dendritic cells, vesicular stomatitis virus glycoprotein G but not LPS promotes the activation of IRF7, leading to type I IFN production in a CD14-dependent manner (PubMed:23880187, PubMed:15265881). {ECO:0000269|PubMed:10835634, ECO:0000269|PubMed:14517278, ECO:0000269|PubMed:15265881, ECO:0000269|PubMed:15809303, ECO:0000269|PubMed:16622205, ECO:0000269|PubMed:17292937, ECO:0000269|PubMed:17478729, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:20711192, ECO:0000269|PubMed:23880187, ECO:0000269|PubMed:27022195, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:9237759}.	MISCELLANEOUS: His-456 and His-458 are found in TLR4 of human and several other primate species and may be responsible for inflammatory responses triggered by nickel (Ni(2+)). Ni(2+) may cross-link the two receptor monomers through specific histidines, triggering the formation of a dimer that structurally resembles that induced by LPS. This process may be the basis for the development of contact allergy to Ni(2+). A mouse model of contact allergy to Ni(2+) in which TLR4-deficient mice expresses human TLR4 has been proposed. {ECO:0000305|PubMed:20711192}.	astrocyte development [GO:0014002]; B cell proliferation involved in immune response [GO:0002322]; cellular response to amyloid-beta [GO:1904646]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to mechanical stimulus [GO:0071260]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to type II interferon [GO:0071346]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; detection of fungus [GO:0016046]; detection of lipopolysaccharide [GO:0032497]; ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intestinal epithelial structure maintenance [GO:0060729]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation [GO:0042116]; MHC class II biosynthetic process [GO:0045342]; microglia differentiation [GO:0014004]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-23 production [GO:0032707]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide production involved in inflammatory response [GO:0002537]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; phagocytosis [GO:0006909]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cellular response to macrophage colony-stimulating factor stimulus [GO:1903974]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of platelet activation [GO:0010572]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of dendritic cell cytokine production [GO:0002730]; response to lipopolysaccharide [GO:0032496]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; wound healing involved in inflammatory response [GO:0002246]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; lipopolysaccharide receptor complex [GO:0046696]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ruffle [GO:0001726]	amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; lipopolysaccharide receptor complex [GO:0046696]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ruffle [GO:0001726]; amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]; astrocyte development [GO:0014002]; B cell proliferation involved in immune response [GO:0002322]; cellular response to amyloid-beta [GO:1904646]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to mechanical stimulus [GO:0071260]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to type II interferon [GO:0071346]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; detection of fungus [GO:0016046]; detection of lipopolysaccharide [GO:0032497]; ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intestinal epithelial structure maintenance [GO:0060729]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation [GO:0042116]; MHC class II biosynthetic process [GO:0045342]; microglia differentiation [GO:0014004]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-23 production [GO:0032707]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide production involved in inflammatory response [GO:0002537]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; phagocytosis [GO:0006909]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cellular response to macrophage colony-stimulating factor stimulus [GO:1903974]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of platelet activation [GO:0010572]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of dendritic cell cytokine production [GO:0002730]; response to lipopolysaccharide [GO:0032496]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; wound healing involved in inflammatory response [GO:0002246]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11274165, ECO:0000269|PubMed:17098818, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:21393102, ECO:0000269|PubMed:27022195, ECO:0000269|PubMed:9237759}; Single-pass type I membrane protein {ECO:0000269|PubMed:11274165}. Early endosome {ECO:0000269|PubMed:27022195}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9QUK6}. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis (PubMed:20037584). Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation. {ECO:0000269|PubMed:20037584}.
O00212	reviewed	RHOD_HUMAN	Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1)	RHOD ARHD	Homo sapiens (Human)	210	FUNCTION: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. {ECO:0000269|PubMed:23087206, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:24102721}.		actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; focal adhesion assembly [GO:0048041]; lamellipodium assembly [GO:0030032]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; focal adhesion assembly [GO:0048041]; lamellipodium assembly [GO:0030032]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:24102721}. Note=Colocalizes with RAB5 to early endosomes (By similarity). {ECO:0000250|UniProtKB:P97348}.
O00213	reviewed	APBB1_HUMAN	Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65)	APBB1 FE65 RIR	Homo sapiens (Human)	710	FUNCTION: Transcription coregulator that can have both coactivator and corepressor functions (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469, PubMed:33938178). Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 (PubMed:19234442). Required for histone H4 acetylation at double-strand breaks (DSBs) (PubMed:19234442). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed:33938178). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 (PubMed:19343227). Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Plays a role in the maintenance of lens transparency (By similarity). May play a role in muscle cell strength (By similarity). {ECO:0000250|UniProtKB:Q9QXJ1, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:18468999, ECO:0000269|PubMed:18922798, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:25342469, ECO:0000269|PubMed:33938178}.		apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein secretion [GO:0050714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]	amyloid-beta binding [GO:0001540]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; low-density lipoprotein particle receptor binding [GO:0050750]; proline-rich region binding [GO:0070064]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; amyloid-beta binding [GO:0001540]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; low-density lipoprotein particle receptor binding [GO:0050750]; proline-rich region binding [GO:0070064]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein secretion [GO:0050714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18468999}. Cytoplasm {ECO:0000269|PubMed:18468999}. Nucleus {ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:18468999, ECO:0000269|PubMed:18922798, ECO:0000269|PubMed:19343227}. Cell projection, growth cone {ECO:0000250|UniProtKB:P46933}. Nucleus speckle {ECO:0000269|PubMed:17512906}. Note=Colocalizes with TSHZ3 in axonal growth cone (By similarity). Colocalizes with TSHZ3 in the nucleus (PubMed:19343227). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP (PubMed:18468999). Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus (PubMed:18468999). Nuclear translocation is under the regulation of APP (PubMed:18468999). Colocalizes with NEK6 at the nuclear speckles (PubMed:17512906). Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). {ECO:0000250|UniProtKB:P46933, ECO:0000269|PubMed:17512906, ECO:0000269|PubMed:18468999, ECO:0000269|PubMed:19343227}.
O00214	reviewed	LEG8_HUMAN	Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)	LGALS8	Homo sapiens (Human)	317	FUNCTION: Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902). {ECO:0000269|PubMed:21288902, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:28077878}.		cellular response to virus [GO:0098586]; lymphatic endothelial cell migration [GO:1904977]; xenophagy [GO:0098792]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]	carbohydrate binding [GO:0030246]; integrin binding [GO:0005178]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; carbohydrate binding [GO:0030246]; integrin binding [GO:0005178]; cellular response to virus [GO:0098586]; lymphatic endothelial cell migration [GO:1904977]; xenophagy [GO:0098792]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:22246324}. Cytoplasm, cytosol {ECO:0000269|PubMed:22246324}.
O00217	reviewed	NDUS8_HUMAN	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 7.1.1.2) (Complex I-23kD) (CI-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit) (TYKY subunit)	NDUFS8	Homo sapiens (Human)	210	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:22499348). Essential for the catalytic activity and assembly of complex I (PubMed:22499348). {ECO:0000269|PubMed:22499348}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to oxidative stress [GO:0006979]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891, ECO:0000305|PubMed:9666055}; Peripheral membrane protein {ECO:0000250|UniProtKB:P42028}; Matrix side {ECO:0000250|UniProtKB:P42028}.
O00219	reviewed	HYAS3_HUMAN	Hyaluronan synthase 3 (EC 2.4.1.212) (Hyaluronate synthase 3) (Hyaluronic acid synthase 3) (HA synthase 3)	HAS3	Homo sapiens (Human)	553	FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis. {ECO:0000269|PubMed:23303191, ECO:0000269|PubMed:25795779, ECO:0000269|PubMed:26883802}.		carbohydrate metabolic process [GO:0005975]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; hyaluronan biosynthetic process [GO:0030213]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hyaluranon cable assembly [GO:1900106]	early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; hyaluranon cable [GO:0036117]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802]	early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; hyaluranon cable [GO:0036117]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802]; carbohydrate metabolic process [GO:0005975]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; hyaluronan biosynthetic process [GO:0030213]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hyaluranon cable assembly [GO:1900106]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25795779, ECO:0000269|PubMed:26883802, ECO:0000269|PubMed:30394292}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:25795779}; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:O08650}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:26883802}. Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane (PubMed:26883802). Actives only when present in plasma membrane (By similarity). O-GlcNAcylation controls its membrane localization (PubMed:26883802). A rapid recycling of HAS3 between plasma membrane and endosomes is controlled by the cytosolic levels of UDP-GlcUA and UDP-GlcNAc (PubMed:26883802). {ECO:0000250|UniProtKB:O08650, ECO:0000269|PubMed:26883802}.
O00220	reviewed	TR10A_HUMAN	Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)	TNFRSF10A APO2 DR4 TRAILR1	Homo sapiens (Human)	468	FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227). {ECO:0000269|PubMed:19090789, ECO:0000269|PubMed:9430227}.		activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	cell surface [GO:0009986]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	death receptor activity [GO:0005035]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; TRAIL binding [GO:0045569]	cell surface [GO:0009986]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; death receptor activity [GO:0005035]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; TRAIL binding [GO:0045569]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22240897}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:19090789, ECO:0000269|PubMed:22240897}. Cytoplasm, cytosol {ECO:0000269|PubMed:22240897}. Note=Palmitoylation is required for association with membranes. {ECO:0000269|PubMed:22240897}.
O00221	reviewed	IKBE_HUMAN	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)	NFKBIE IKBE	Homo sapiens (Human)	500	FUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:9315679}.		cytoplasmic sequestering of transcription factor [GO:0042994]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; cytoplasmic sequestering of transcription factor [GO:0042994]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O00222	reviewed	GRM8_HUMAN	Metabotropic glutamate receptor 8 (mGluR8)	GRM8 GPRC1H MGLUR8	Homo sapiens (Human)	908	FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:9473604}.		adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; regulation of synaptic transmission, glutamatergic [GO:0051966]; visual perception [GO:0007601]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]; adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; regulation of synaptic transmission, glutamatergic [GO:0051966]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O00231	reviewed	PSD11_HUMAN	26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5)	PSMD11	Homo sapiens (Human)	422	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22972301}.		proteasome assembly [GO:0043248]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; stem cell differentiation [GO:0048863]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]; structural molecule activity [GO:0005198]; proteasome assembly [GO:0043248]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; stem cell differentiation [GO:0048863]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
O00232	reviewed	PSD12_HUMAN	26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55)	PSMD12	Homo sapiens (Human)	456	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	
O00233	reviewed	PSMD9_HUMAN	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27)	PSMD9	Homo sapiens (Human)	223	FUNCTION: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. {ECO:0000269|PubMed:19490896}.		negative regulation of insulin secretion [GO:0046676]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion [GO:0032024]; proteasome regulatory particle assembly [GO:0070682]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome regulatory particle [GO:0005838]	bHLH transcription factor binding [GO:0043425]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome regulatory particle [GO:0005838]; bHLH transcription factor binding [GO:0043425]; transcription coactivator activity [GO:0003713]; negative regulation of insulin secretion [GO:0046676]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion [GO:0032024]; proteasome regulatory particle assembly [GO:0070682]; ubiquitin-dependent protein catabolic process [GO:0006511]	
O00237	reviewed	RN103_HUMAN	E3 ubiquitin-protein ligase RNF103 (EC 2.3.2.27) (KF-1) (hKF-1) (RING finger protein 103) (RING-type E3 ubiquitin transferase RNF103) (Zinc finger protein 103 homolog) (Zfp-103)	RNF103 ZFP103	Homo sapiens (Human)	685	FUNCTION: Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:18675248}.		central nervous system development [GO:0007417]; protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; central nervous system development [GO:0007417]; protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18675248}; Multi-pass membrane protein {ECO:0000269|PubMed:18675248}.
O00238	reviewed	BMR1B_HUMAN	Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)	BMPR1B	Homo sapiens (Human)	502	FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction. {ECO:0000250|UniProtKB:P36898}.		BMP signaling pathway [GO:0030509]; cartilage condensation [GO:0001502]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; central nervous system neuron differentiation [GO:0021953]; chondrocyte development [GO:0002063]; dorsal/ventral pattern formation [GO:0009953]; endochondral bone morphogenesis [GO:0060350]; eye development [GO:0001654]; inflammatory response [GO:0006954]; negative regulation of chondrocyte proliferation [GO:1902731]; osteoblast differentiation [GO:0001649]; ovarian cumulus expansion [GO:0001550]; ovulation cycle [GO:0042698]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; proteoglycan biosynthetic process [GO:0030166]; retina development in camera-type eye [GO:0060041]; retinal ganglion cell axon guidance [GO:0031290]	dendrite [GO:0030425]; HFE-transferrin receptor complex [GO:1990712]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta receptor activity, type I [GO:0005025]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]	dendrite [GO:0030425]; HFE-transferrin receptor complex [GO:1990712]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta receptor activity, type I [GO:0005025]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; BMP signaling pathway [GO:0030509]; cartilage condensation [GO:0001502]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; central nervous system neuron differentiation [GO:0021953]; chondrocyte development [GO:0002063]; dorsal/ventral pattern formation [GO:0009953]; endochondral bone morphogenesis [GO:0060350]; eye development [GO:0001654]; inflammatory response [GO:0006954]; negative regulation of chondrocyte proliferation [GO:1902731]; osteoblast differentiation [GO:0001649]; ovarian cumulus expansion [GO:0001550]; ovulation cycle [GO:0042698]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; proteoglycan biosynthetic process [GO:0030166]; retina development in camera-type eye [GO:0060041]; retinal ganglion cell axon guidance [GO:0031290]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P36898}; Single-pass type I membrane protein {ECO:0000255}.
O00241	reviewed	SIRB1_HUMAN	Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b)	SIRPB1	Homo sapiens (Human)	398	FUNCTION: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985). {ECO:0000269|PubMed:10604985}.		cell surface receptor signaling pathway [GO:0007166]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870]; signal transduction [GO:0007165]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]		cell surface [GO:0009986]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10604985}; Single-pass type I membrane protein {ECO:0000255}.
O00244	reviewed	ATOX1_HUMAN	Copper transport protein ATOX1 (Metal transport protein ATX1)	ATOX1 HAH1	Homo sapiens (Human)	68	FUNCTION: Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.		copper ion transport [GO:0006825]; intracellular copper ion homeostasis [GO:0006878]; response to oxidative stress [GO:0006979]	cytosol [GO:0005829]	copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]; copper-dependent protein binding [GO:0032767]; cuprous ion binding [GO:1903136]; metallochaperone activity [GO:0016530]	cytosol [GO:0005829]; copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]; copper-dependent protein binding [GO:0032767]; cuprous ion binding [GO:1903136]; metallochaperone activity [GO:0016530]; copper ion transport [GO:0006825]; intracellular copper ion homeostasis [GO:0006878]; response to oxidative stress [GO:0006979]	
O00253	reviewed	AGRP_HUMAN	Agouti-related protein	AGRP AGRT ART	Homo sapiens (Human)	132	FUNCTION: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. {ECO:0000250, ECO:0000269|PubMed:10371151, ECO:0000269|PubMed:11145747, ECO:0000269|PubMed:15927146, ECO:0000269|PubMed:17041250, ECO:0000269|PubMed:9892020}.		adult feeding behavior [GO:0008343]; circadian rhythm [GO:0007623]; eating behavior [GO:0042755]; feeding behavior [GO:0007631]; hormone-mediated signaling pathway [GO:0009755]; long-day photoperiodism [GO:0048571]; maternal process involved in female pregnancy [GO:0060135]; neuropeptide signaling pathway [GO:0007218]; positive regulation of feeding behavior [GO:2000253]; regulation of feeding behavior [GO:0060259]; response to insulin [GO:0032868]	extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; neuronal cell body [GO:0043025]	neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102]; type 1 melanocortin receptor binding [GO:0070996]	extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; neuronal cell body [GO:0043025]; neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102]; type 1 melanocortin receptor binding [GO:0070996]; adult feeding behavior [GO:0008343]; circadian rhythm [GO:0007623]; eating behavior [GO:0042755]; feeding behavior [GO:0007631]; hormone-mediated signaling pathway [GO:0009755]; long-day photoperiodism [GO:0048571]; maternal process involved in female pregnancy [GO:0060135]; neuropeptide signaling pathway [GO:0007218]; positive regulation of feeding behavior [GO:2000253]; regulation of feeding behavior [GO:0060259]; response to insulin [GO:0032868]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15927146}. Golgi apparatus lumen {ECO:0000269|PubMed:15927146}.
O00254	reviewed	PAR3_HUMAN	Proteinase-activated receptor 3 (PAR-3) (Coagulation factor II receptor-like 2) (Thrombin receptor-like 2)	F2RL2 PAR3	Homo sapiens (Human)	374	FUNCTION: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. {ECO:0000269|PubMed:10079109}.		blood coagulation [GO:0007596]; ligand-gated ion channel signaling pathway [GO:1990806]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; positive regulation of insulin secretion [GO:0032024]; positive regulation of Rho protein signal transduction [GO:0035025]; response to wounding [GO:0009611]	apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	G protein-coupled receptor activity [GO:0004930]; phosphatidylinositol phospholipase C activity [GO:0004435]; receptor ligand activity [GO:0048018]; thrombin-activated receptor activity [GO:0015057]	apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; G protein-coupled receptor activity [GO:0004930]; phosphatidylinositol phospholipase C activity [GO:0004435]; receptor ligand activity [GO:0048018]; thrombin-activated receptor activity [GO:0015057]; blood coagulation [GO:0007596]; ligand-gated ion channel signaling pathway [GO:1990806]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; positive regulation of insulin secretion [GO:0032024]; positive regulation of Rho protein signal transduction [GO:0035025]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O00255	reviewed	MEN1_HUMAN	Menin	MEN1 SCG2	Homo sapiens (Human)	610	FUNCTION: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. {ECO:0000250|UniProtKB:O88559, ECO:0000269|PubMed:11274402, ECO:0000269|PubMed:11526476, ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:12874027, ECO:0000269|PubMed:14992727, ECO:0000269|PubMed:22327296}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JNK cascade [GO:0046329]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of telomerase activity [GO:0051974]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast development [GO:0002076]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gamma radiation [GO:0010332]; response to UV [GO:0009411]; T-helper 2 cell differentiation [GO:0045064]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; phosphoprotein binding [GO:0051219]; protein-macromolecule adaptor activity [GO:0030674]; R-SMAD binding [GO:0070412]; transcription cis-regulatory region binding [GO:0000976]; Y-form DNA binding [GO:0000403]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; phosphoprotein binding [GO:0051219]; protein-macromolecule adaptor activity [GO:0030674]; R-SMAD binding [GO:0070412]; transcription cis-regulatory region binding [GO:0000976]; Y-form DNA binding [GO:0000403]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JNK cascade [GO:0046329]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of telomerase activity [GO:0051974]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast development [GO:0002076]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gamma radiation [GO:0010332]; response to UV [GO:0009411]; T-helper 2 cell differentiation [GO:0045064]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12874027}. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
O00257	reviewed	CBX4_HUMAN	E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)	CBX4	Homo sapiens (Human)	560	FUNCTION: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}.	MISCELLANEOUS: The human orthologs of the Drosophila Polycomb group protein Pc are CBX2, CBX4, CBX6, CBX7 and CBX8. These show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purified in PubMed:12167701 probably presents a mixture of different complexes containing different Polycomb group proteins.	chromatin organization [GO:0006325]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein sumoylation [GO:0016925]	nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; methylated histone binding [GO:0035064]; phosphoprotein binding [GO:0051219]; single-stranded RNA binding [GO:0003727]; SUMO binding [GO:0032183]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]	nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; methylated histone binding [GO:0035064]; phosphoprotein binding [GO:0051219]; single-stranded RNA binding [GO:0003727]; SUMO binding [GO:0032183]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]; chromatin organization [GO:0006325]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein sumoylation [GO:0016925]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. Nucleus speckle {ECO:0000269|PubMed:19266028}. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235). {ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:22467880}.
O00258	reviewed	GET1_HUMAN	Guided entry of tail-anchored proteins factor 1 (Congenital heart disease 5 protein) (Tail-anchored protein insertion receptor WRB) (Tryptophan-rich basic protein)	GET1 CHD5 WRB	Homo sapiens (Human)	174	FUNCTION: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539). Required to ensure correct topology and ER insertion of CAMLG (PubMed:31417168, PubMed:32187542). {ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:24392163, ECO:0000269|PubMed:27226539, ECO:0000269|PubMed:31417168, ECO:0000269|PubMed:32187542}.		protein insertion into ER membrane [GO:0045048]; protein stabilization [GO:0050821]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	endoplasmic reticulum membrane [GO:0005789]; GET complex [GO:0043529]; nucleus [GO:0005634]	protein-membrane adaptor activity [GO:0043495]	endoplasmic reticulum membrane [GO:0005789]; GET complex [GO:0043529]; nucleus [GO:0005634]; protein-membrane adaptor activity [GO:0043495]; protein insertion into ER membrane [GO:0045048]; protein stabilization [GO:0050821]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21444755}; Multi-pass membrane protein {ECO:0000255}.
O00264	reviewed	PGRC1_HUMAN	Membrane-associated progesterone receptor component 1 (mPR) (Dap1) (IZA)	PGRMC1 HPR6.6 PGRMC	Homo sapiens (Human)	195	FUNCTION: Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036). {ECO:0000250|UniProtKB:O55022, ECO:0000269|PubMed:25675345, ECO:0000269|PubMed:27599036, ECO:0000303|PubMed:28396637}.	MISCELLANEOUS: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). {ECO:0000303|PubMed:23763432, ECO:0000303|PubMed:28396637}.	heme biosynthetic process [GO:0006783]; positive regulation of protein localization to plasma membrane [GO:1903078]	cell body [GO:0044297]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; specific granule membrane [GO:0035579]; synapse [GO:0045202]	amyloid-beta binding [GO:0001540]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; steroid binding [GO:0005496]	cell body [GO:0044297]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; specific granule membrane [GO:0035579]; synapse [GO:0045202]; amyloid-beta binding [GO:0001540]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; steroid binding [GO:0005496]; heme biosynthetic process [GO:0006783]; positive regulation of protein localization to plasma membrane [GO:1903078]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:Q95250}; Single-pass membrane protein {ECO:0000255}. Smooth endoplasmic reticulum membrane {ECO:0000303|PubMed:28396637}; Single-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:O55022}; Single-pass membrane protein {ECO:0000305}; Extracellular side {ECO:0000250|UniProtKB:O55022}. Secreted {ECO:0000269|PubMed:36213313}.
O00267	reviewed	SPT5H_HUMAN	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)	SUPT5H SPT5 SPT5H	Homo sapiens (Human)	1087	FUNCTION: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences. {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}.		negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of macroautophagy [GO:0016239]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673]	DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]	DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of macroautophagy [GO:0016239]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10075709}.
O00268	reviewed	TAF4_HUMAN	Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135)	TAF4 TAF2C TAF2C1 TAF4A TAFII130 TAFII135	Homo sapiens (Human)	1085	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:10594036, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867). {ECO:0000269|PubMed:10594036, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:8942982, ECO:0000269|PubMed:9192867}.		DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; ovarian follicle development [GO:0001541]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	chromatin [GO:0000785]; cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]	aryl hydrocarbon receptor binding [GO:0017162]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]	chromatin [GO:0000785]; cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; aryl hydrocarbon receptor binding [GO:0017162]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; ovarian follicle development [GO:0001541]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus.
O00270	reviewed	GPR31_HUMAN	12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor (12-(S)-HETE receptor) (12-HETER) (G-protein coupled receptor 31) (GPR31/12-HETER)	GPR31	Homo sapiens (Human)	319	FUNCTION: High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers (PubMed:21712392, PubMed:29227475). 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes (PubMed:26965684, PubMed:28619714, PubMed:29227475). 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways leading to cell growth (PubMed:21712392, PubMed:29227475). Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM (PubMed:28619714). Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens (By similarity). Acts also as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury (PubMed:29227475). {ECO:0000250|UniProtKB:F8VQN3, ECO:0000269|PubMed:21712392, ECO:0000269|PubMed:26965684, ECO:0000269|PubMed:28619714, ECO:0000269|PubMed:29227475}.; FUNCTION: Proton-sensing G protein-coupled receptor. {ECO:0000269|PubMed:31119277}.		G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; negative regulation of inflammatory response [GO:0050728]; positive regulation of immune response [GO:0050778]; response to acidic pH [GO:0010447]; response to ischemia [GO:0002931]; response to molecule of bacterial origin [GO:0002237]	plasma membrane [GO:0005886]	arachidonic acid binding [GO:0050544]; bioactive lipid receptor activity [GO:0045125]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; arachidonic acid binding [GO:0050544]; bioactive lipid receptor activity [GO:0045125]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; negative regulation of inflammatory response [GO:0050728]; positive regulation of immune response [GO:0050778]; response to acidic pH [GO:0010447]; response to ischemia [GO:0002931]; response to molecule of bacterial origin [GO:0002237]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21712392, ECO:0000269|PubMed:28619714, ECO:0000269|PubMed:31119277}; Multi-pass membrane protein {ECO:0000255}.
O00273	reviewed	DFFA_HUMAN	DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD)	DFFA DFF1 DFF45 H13	Homo sapiens (Human)	331	FUNCTION: Inhibitor of the caspase-activated DNase (DFF40).		apoptotic DNA fragmentation [GO:0006309]; chaperone-mediated protein folding [GO:0061077]; negative regulation of apoptotic DNA fragmentation [GO:1902511]; negative regulation of deoxyribonuclease activity [GO:0032076]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of apoptotic process [GO:0043065]; thymocyte apoptotic process [GO:0070242]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	deoxyribonuclease inhibitor activity [GO:0060703]; protein domain specific binding [GO:0019904]; protein folding chaperone [GO:0044183]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; deoxyribonuclease inhibitor activity [GO:0060703]; protein domain specific binding [GO:0019904]; protein folding chaperone [GO:0044183]; apoptotic DNA fragmentation [GO:0006309]; chaperone-mediated protein folding [GO:0061077]; negative regulation of apoptotic DNA fragmentation [GO:1902511]; negative regulation of deoxyribonuclease activity [GO:0032076]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of apoptotic process [GO:0043065]; thymocyte apoptotic process [GO:0070242]	SUBCELLULAR LOCATION: Cytoplasm.
O00287	reviewed	RFXAP_HUMAN	Regulatory factor X-associated protein (RFX-associated protein) (RFX DNA-binding complex 36 kDa subunit)	RFXAP	Homo sapiens (Human)	272	FUNCTION: Part of the RFX complex that binds to the X-box of MHC II promoters.		positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
O00291	reviewed	HIP1_HUMAN	Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I)	HIP1	Homo sapiens (Human)	1037	FUNCTION: Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). {ECO:0000250|UniProtKB:Q8VD75, ECO:0000269|PubMed:11007801, ECO:0000269|PubMed:11532990, ECO:0000269|PubMed:11577110, ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:12163454, ECO:0000269|PubMed:14732715, ECO:0000269|PubMed:16027218, ECO:0000269|PubMed:18790740, ECO:0000269|PubMed:9147654}.	MISCELLANEOUS: The affinity of the huntingtin protein-HIP1 interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.	actin filament organization [GO:0007015]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897]; neurotransmitter receptor transport [GO:0099637]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; positive regulation of receptor-mediated endocytosis [GO:0048260]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of endocytosis [GO:0030100]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]	clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]	actin filament binding [GO:0051015]; AP-2 adaptor complex binding [GO:0035612]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; clathrin light chain binding [GO:0032051]; epidermal growth factor receptor binding [GO:0005154]; glutamate receptor binding [GO:0035254]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of cytoskeleton [GO:0005200]	clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; actin filament binding [GO:0051015]; AP-2 adaptor complex binding [GO:0035612]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; clathrin light chain binding [GO:0032051]; epidermal growth factor receptor binding [GO:0005154]; glutamate receptor binding [GO:0035254]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of cytoskeleton [GO:0005200]; actin filament organization [GO:0007015]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897]; neurotransmitter receptor transport [GO:0099637]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; positive regulation of receptor-mediated endocytosis [GO:0048260]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of endocytosis [GO:0030100]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
O00292	reviewed	LFTY2_HUMAN	Left-right determination factor 2 (Endometrial bleeding-associated factor) (Left-right determination factor A) (Protein lefty-2) (Protein lefty-A) (Transforming growth factor beta-4) (TGF-beta-4)	LEFTY2 EBAF LEFTA LEFTYA TGFB4 PSEC0024	Homo sapiens (Human)	366	FUNCTION: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.		anterior/posterior axis specification [GO:0009948]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; transforming growth factor beta receptor binding [GO:0005160]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; transforming growth factor beta receptor binding [GO:0005160]; anterior/posterior axis specification [GO:0009948]	SUBCELLULAR LOCATION: Secreted.
O00294	reviewed	TULP1_HUMAN	Tubby-related protein 1 (Tubby-like protein 1)	TULP1 TUBL1	Homo sapiens (Human)	542	FUNCTION: Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269|PubMed:16303976, ECO:0000269|PubMed:19837063}.		dendrite development [GO:0016358]; detection of light stimulus involved in visual perception [GO:0050908]; eye photoreceptor cell development [GO:0042462]; phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to cilium [GO:0061512]; protein localization to photoreceptor outer segment [GO:1903546]; retina development in camera-type eye [GO:0060041]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]	axon terminus [GO:0043679]; cell projection [GO:0042995]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; synapse [GO:0045202]	actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	axon terminus [GO:0043679]; cell projection [GO:0042995]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; synapse [GO:0045202]; actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; dendrite development [GO:0016358]; detection of light stimulus involved in visual perception [GO:0050908]; eye photoreceptor cell development [GO:0042462]; phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to cilium [GO:0061512]; protein localization to photoreceptor outer segment [GO:1903546]; retina development in camera-type eye [GO:0060041]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16303976}. Cell membrane {ECO:0000269|PubMed:16303976}; Peripheral membrane protein {ECO:0000269|PubMed:16303976}; Cytoplasmic side {ECO:0000269|PubMed:16303976}. Secreted {ECO:0000250}. Synapse {ECO:0000250}. Note=Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway (By similarity). {ECO:0000250}.
O00299	reviewed	CLIC1_HUMAN	Chloride intracellular channel protein 1 (Chloride channel ABP) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC)	CLIC1 G6 NCC27	Homo sapiens (Human)	241	FUNCTION: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. {ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:11195932, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:9139710}.	MISCELLANEOUS: The protein seems to have very low affinity for glutathione, even though glutathione binding was observed in protein crystals.	chloride transport [GO:0006821]; platelet aggregation [GO:0070527]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of monoatomic ion transmembrane transport [GO:0034765]; signal transduction [GO:0007165]	blood microparticle [GO:0072562]; brush border [GO:0005903]; chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	cadherin binding [GO:0045296]; chloride channel activity [GO:0005254]; voltage-gated monoatomic ion channel activity [GO:0005244]	blood microparticle [GO:0072562]; brush border [GO:0005903]; chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; chloride channel activity [GO:0005254]; voltage-gated monoatomic ion channel activity [GO:0005244]; chloride transport [GO:0006821]; platelet aggregation [GO:0070527]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of monoatomic ion transmembrane transport [GO:0034765]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12681486, ECO:0000269|PubMed:9139710}. Nucleus membrane {ECO:0000269|PubMed:9139710}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:12681486, ECO:0000269|PubMed:9139710, ECO:0000305|PubMed:11978800, ECO:0000305|PubMed:14613939}. Cell membrane {ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:14613939, ECO:0000305|PubMed:11978800}; Single-pass membrane protein {ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:14613939}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6MG61}. Note=Mostly in the nucleus including in the nuclear membrane (PubMed:9139710, PubMed:12681486). Small amount in the cytoplasm and the plasma membrane (PubMed:9139710). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (PubMed:11940526, PubMed:11551966, PubMed:14613939, PubMed:12681486, PubMed:9139710). Might not be present in the nucleus of cardiac cells (By similarity). {ECO:0000250|UniProtKB:Q6MG61, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:12681486, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:9139710}.
O00300	reviewed	TR11B_HUMAN	Tumor necrosis factor receptor superfamily member 11B (Osteoclastogenesis inhibitory factor) (Osteoprotegerin)	TNFRSF11B OCIF OPG	Homo sapiens (Human)	401	FUNCTION: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:22664871, ECO:0000269|PubMed:9168977}.		apoptotic process [GO:0006915]; extracellular matrix organization [GO:0030198]; negative regulation of bone resorption [GO:0045779]; negative regulation of odontogenesis of dentin-containing tooth [GO:0042489]; negative regulation of osteoclast differentiation [GO:0045671]; response to arsenic-containing substance [GO:0046685]; response to estrogen [GO:0043627]; response to magnesium ion [GO:0032026]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine activity [GO:0005125]; signaling receptor activity [GO:0038023]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine activity [GO:0005125]; signaling receptor activity [GO:0038023]; apoptotic process [GO:0006915]; extracellular matrix organization [GO:0030198]; negative regulation of bone resorption [GO:0045779]; negative regulation of odontogenesis of dentin-containing tooth [GO:0042489]; negative regulation of osteoclast differentiation [GO:0045671]; response to arsenic-containing substance [GO:0046685]; response to estrogen [GO:0043627]; response to magnesium ion [GO:0032026]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted.
O00303	reviewed	EIF3F_HUMAN	Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47)	EIF3F EIF3S5	Homo sapiens (Human)	357	FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03005, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling. {ECO:0000269|PubMed:21124883}.		formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; protein deubiquitination [GO:0016579]; translational initiation [GO:0006413]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; synapse [GO:0045202]	cysteine-type deubiquitinase activity [GO:0004843]; identical protein binding [GO:0042802]; metal-dependent deubiquitinase activity [GO:0140492]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; synapse [GO:0045202]; cysteine-type deubiquitinase activity [GO:0004843]; identical protein binding [GO:0042802]; metal-dependent deubiquitinase activity [GO:0140492]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]; formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; protein deubiquitination [GO:0016579]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
O00305	reviewed	CACB4_HUMAN	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4)	CACNB4 CACNLB4	Homo sapiens (Human)	520	FUNCTION: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. {ECO:0000269|PubMed:11880487}.	MISCELLANEOUS: [Isoform 4]: Unable to interact with the alpha-1 subunit. {ECO:0000305}.	adult walking behavior [GO:0007628]; cAMP metabolic process [GO:0046058]; cellular response to leukemia inhibitory factor [GO:1990830]; chemical synaptic transmission [GO:0007268]; detection of light stimulus involved in visual perception [GO:0050908]; gamma-aminobutyric acid secretion [GO:0014051]; gamma-aminobutyric acid signaling pathway [GO:0007214]; muscle cell development [GO:0055001]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; neuromuscular junction development [GO:0007528]; neuronal action potential propagation [GO:0019227]; Peyer's patch development [GO:0048541]; positive regulation of protein localization to nucleolus [GO:1904751]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of voltage-gated calcium channel activity [GO:1901385]; spleen development [GO:0048536]; synaptic transmission, glutamatergic [GO:0035249]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]	protein kinase binding [GO:0019901]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]; protein kinase binding [GO:0019901]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626]; adult walking behavior [GO:0007628]; cAMP metabolic process [GO:0046058]; cellular response to leukemia inhibitory factor [GO:1990830]; chemical synaptic transmission [GO:0007268]; detection of light stimulus involved in visual perception [GO:0050908]; gamma-aminobutyric acid secretion [GO:0014051]; gamma-aminobutyric acid signaling pathway [GO:0007214]; muscle cell development [GO:0055001]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; neuromuscular junction development [GO:0007528]; neuronal action potential propagation [GO:0019227]; Peyer's patch development [GO:0048541]; positive regulation of protein localization to nucleolus [GO:1904751]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of voltage-gated calcium channel activity [GO:1901385]; spleen development [GO:0048536]; synaptic transmission, glutamatergic [GO:0035249]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]	
O00308	reviewed	WWP2_HUMAN	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)	WWP2	Homo sapiens (Human)	870	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. {ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:19651900}.	MISCELLANEOUS: A cysteine residue is required for ubiquitin-thioester formation.	extracellular transport [GO:0006858]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein transport [GO:0051224]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transporter activity [GO:0032410]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; transcription by RNA polymerase II [GO:0006366]; viral entry into host cell [GO:0046718]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription factor binding [GO:0008134]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription factor binding [GO:0008134]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; extracellular transport [GO:0006858]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein transport [GO:0051224]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transporter activity [GO:0032410]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; transcription by RNA polymerase II [GO:0006366]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:20858735}.
O00311	reviewed	CDC7_HUMAN	Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1)	CDC7 CDC7L1	Homo sapiens (Human)	574	FUNCTION: Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}.		cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; double-strand break repair via break-induced replication [GO:0000727]; G1/S transition of mitotic cell cycle [GO:0000082]; phosphorylation [GO:0016310]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; double-strand break repair via break-induced replication [GO:0000727]; G1/S transition of mitotic cell cycle [GO:0000082]; phosphorylation [GO:0016310]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:27401717}.
O00322	reviewed	UPK1A_HUMAN	Uroplakin-1a (UP1a) (Tetraspanin-21) (Tspan-21) (Uroplakin Ia) (UPIa) (UPKa)	UPK1A TSPAN21	Homo sapiens (Human)	258	FUNCTION: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity). {ECO:0000250}.		epithelial cell differentiation [GO:0030855]	apical plasma membrane urothelial plaque [GO:0120001]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]		apical plasma membrane urothelial plaque [GO:0120001]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; epithelial cell differentiation [GO:0030855]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
O00327	reviewed	BMAL1_HUMAN	Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3)	BMAL1 ARNTL BHLHE5 MOP3 PASD3	Homo sapiens (Human)	626	FUNCTION: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repressBMAL1 transcription, respectively.BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). {ECO:0000250|UniProtKB:Q9WTL8, ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:23955654, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.; FUNCTION: (Microbial infection) Regulates SARS coronavirus-2/SARS-CoV-2 entry and replication in lung epithelial cells probably through the post-transcriptional regulation of ACE2 and interferon-stimulated gene expression. {ECO:0000269|PubMed:34545347}.	MISCELLANEOUS: CLOCK-BMAL1 double mutations within the PAS domains result in synergistic desensitization to high levels of CRY on repression of CLOCK-BMAL1 transcriptional activity of PER1 and, disrupt circadian rhythmicity.	circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of TOR signaling [GO:0032007]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein acetylation [GO:1901985]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell cycle [GO:0051726]; regulation of cellular senescence [GO:2000772]; regulation of DNA-templated transcription [GO:0006355]; regulation of hair cycle [GO:0042634]; regulation of insulin secretion [GO:0050796]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell development [GO:2000074]; response to redox state [GO:0051775]; spermatogenesis [GO:0007283]	aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; chromatoid body [GO:0033391]; CLOCK-BMAL transcription complex [GO:1990513]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	aryl hydrocarbon receptor binding [GO:0017162]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; Hsp90 protein binding [GO:0051879]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; chromatoid body [GO:0033391]; CLOCK-BMAL transcription complex [GO:1990513]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; aryl hydrocarbon receptor binding [GO:0017162]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; Hsp90 protein binding [GO:0051879]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of TOR signaling [GO:0032007]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein acetylation [GO:1901985]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell cycle [GO:0051726]; regulation of cellular senescence [GO:2000772]; regulation of DNA-templated transcription [GO:0006355]; regulation of hair cycle [GO:0042634]; regulation of insulin secretion [GO:0050796]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell development [GO:2000074]; response to redox state [GO:0051775]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:24005054}. Cytoplasm {ECO:0000250|UniProtKB:Q9WTL8}. Nucleus, PML body {ECO:0000250|UniProtKB:Q9WTL8}. Note=Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2. {ECO:0000250|UniProtKB:Q9WTL8}.
O00329	reviewed	PK3CD_HUMAN	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)	PIK3CD	Homo sapiens (Human)	1044	FUNCTION: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:9235916). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity. {ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:20081091, ECO:0000269|PubMed:22020336, ECO:0000269|PubMed:9235916}.	MISCELLANEOUS: IC87114 inhibitor reduces passive cutaneous anaphylaxis, attenuates allergic airway inflammation and hyperresponsiveness and allergen induced rhinitis response. Inhibitors may have therapeutic potential for the treatment of immune system-mediated diseases such as auto-immune diseases, inflammation and allergy (PubMed:20940048, PubMed:17290298).	adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; B cell chemotaxis [GO:0035754]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; natural killer cell activation [GO:0030101]; natural killer cell chemotaxis [GO:0035747]; natural killer cell differentiation [GO:0001779]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration by vascular endothelial growth factor signaling pathway [GO:0038089]; positive regulation of cytokine production [GO:0001819]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein phosphorylation [GO:0006468]; respiratory burst involved in defense response [GO:0002679]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; kinase activity [GO:0016301]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; B cell chemotaxis [GO:0035754]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; natural killer cell activation [GO:0030101]; natural killer cell chemotaxis [GO:0035747]; natural killer cell differentiation [GO:0001779]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration by vascular endothelial growth factor signaling pathway [GO:0038089]; positive regulation of cytokine production [GO:0001819]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein phosphorylation [GO:0006468]; respiratory burst involved in defense response [GO:0002679]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22020336}.
O00330	reviewed	ODPX_HUMAN	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	PDHX PDX1	Homo sapiens (Human)	501	FUNCTION: Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.		acetyl-CoA biosynthetic process from pyruvate [GO:0006086]	mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254]	acyltransferase activity [GO:0016746]	mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254]; acyltransferase activity [GO:0016746]; acetyl-CoA biosynthetic process from pyruvate [GO:0006086]	SUBCELLULAR LOCATION: Mitochondrion matrix.
O00337	reviewed	S28A1_HUMAN	Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1)	SLC28A1 CNT1	Homo sapiens (Human)	649	FUNCTION: Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity. Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (PubMed:9124315, PubMed:10455109, PubMed:14701834, PubMed:15194733, PubMed:21795683, PubMed:21998139, PubMed:32126230, PubMed:30658162). Involved in renal nucleoside (re)absorption (PubMed:30658162). {ECO:0000269|PubMed:10455109, ECO:0000269|PubMed:14701834, ECO:0000269|PubMed:15194733, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:21998139, ECO:0000269|PubMed:30658162, ECO:0000269|PubMed:32126230, ECO:0000269|PubMed:9124315}.	MISCELLANEOUS: Can also transport the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). {ECO:0000269|PubMed:9124315}.	azole transmembrane transport [GO:0045117]; cytidine transport [GO:0015861]; nucleoside import across plasma membrane [GO:0180015]; nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; pyrimidine nucleobase transport [GO:0015855]; pyrimidine-containing compound transmembrane transport [GO:0072531]; uridine transport [GO:0015862]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]	azole transmembrane transporter activity [GO:1901474]; cytidine transmembrane transporter activity [GO:0015212]; nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; azole transmembrane transporter activity [GO:1901474]; cytidine transmembrane transporter activity [GO:0015212]; nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213]; azole transmembrane transport [GO:0045117]; cytidine transport [GO:0015861]; nucleoside import across plasma membrane [GO:0180015]; nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; pyrimidine nucleobase transport [GO:0015855]; pyrimidine-containing compound transmembrane transport [GO:0072531]; uridine transport [GO:0015862]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21998139}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q62674}. Apical cell membrane {ECO:0000269|PubMed:21998139}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q62674}.
O00338	reviewed	ST1C2_HUMAN	Sulfotransferase 1C2 (ST1C2) (EC 2.8.2.1) (Sulfotransferase 1C1) (SULT1C#1) (humSULTC2)	SULT1C2 SULT1C1	Homo sapiens (Human)	296	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Sulfonates p-nitrophenol, a small phenolic compond. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:9852044, PubMed:10783263, PubMed:10481272). Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:9852044). {ECO:0000269|PubMed:10481272, ECO:0000269|PubMed:10783263, ECO:0000269|PubMed:9852044}.		amine metabolic process [GO:0009308]; sulfation [GO:0051923]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]	aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]; aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]; amine metabolic process [GO:0009308]; sulfation [GO:0051923]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O46503}. Lysosome {ECO:0000250|UniProtKB:Q9WUW8}.
O00339	reviewed	MATN2_HUMAN	Matrilin-2	MATN2 UNQ193/PRO219	Homo sapiens (Human)	956	FUNCTION: Involved in matrix assembly. {ECO:0000250}.		extracellular matrix organization [GO:0030198]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted.
O00341	reviewed	EAA5_HUMAN	Excitatory amino acid transporter 5 (Retinal glutamate transporter) (Solute carrier family 1 member 7)	SLC1A7 EAAT5	Homo sapiens (Human)	560	FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:9108121). Acts primarily as an inhibitory glutamate-gated chloride channel being a major inhibitory presynaptic receptor at mammalian rod bipolar cell axon terminals. Glutamate binding gates a large Cl(-) conductance that mediates inhibition, affecting visual processing in the retina (By similarity). {ECO:0000250|UniProtKB:Q8JZR4, ECO:0000269|PubMed:9108121}.		chloride transmembrane transport [GO:1902476]; dicarboxylic acid transport [GO:0006835]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]	plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synaptic membrane [GO:0097060]	extracellularly glutamate-gated chloride channel activity [GO:0008068]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synaptic membrane [GO:0097060]; extracellularly glutamate-gated chloride channel activity [GO:0008068]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; chloride transmembrane transport [GO:1902476]; dicarboxylic acid transport [GO:0006835]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]	SUBCELLULAR LOCATION: Photoreceptor inner segment membrane {ECO:0000250|UniProtKB:Q8JZR4}; Multi-pass membrane protein {ECO:0000255}. Synaptic cell membrane {ECO:0000250|UniProtKB:Q8JZR4}; Multi-pass membrane protein {ECO:0000255}. Note=Located in both cone and rod photoreceptor terminals and in axon terminals of rod bipolar cells. {ECO:0000250|UniProtKB:Q8JZR4}.
O00358	reviewed	FOXE1_HUMAN	Forkhead box protein E1 (Forkhead box protein E2) (Forkhead-related protein FKHL15) (HFKH4) (HNF-3/fork head-like protein 5) (HFKL5) (Thyroid transcription factor 2) (TTF-2)	FOXE1 FKHL15 FOXE2 TITF2 TTF2	Homo sapiens (Human)	373	FUNCTION: Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. {ECO:0000269|PubMed:12165566, ECO:0000269|PubMed:16882747, ECO:0000269|PubMed:20094846, ECO:0000269|PubMed:20484477, ECO:0000269|PubMed:21177256, ECO:0000269|PubMed:24219130, ECO:0000269|PubMed:25381600, ECO:0000269|PubMed:9697705}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cranial skeletal system development [GO:1904888]; embryonic organ morphogenesis [GO:0048562]; hair follicle morphogenesis [GO:0031069]; hard palate development [GO:0060022]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pharynx development [GO:0060465]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; soft palate development [GO:0060023]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; thyroid hormone generation [GO:0006590]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cranial skeletal system development [GO:1904888]; embryonic organ morphogenesis [GO:0048562]; hair follicle morphogenesis [GO:0031069]; hard palate development [GO:0060022]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pharynx development [GO:0060465]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; soft palate development [GO:0060023]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; thyroid hormone generation [GO:0006590]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21177256}.
O00370	reviewed	LORF2_HUMAN	LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)]		Homo sapiens (Human)	1275	FUNCTION: Has reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition (PubMed:9140393, PubMed:7516468). Also has endonuclease activity that allows the introduction of nicks in the chromosomal target DNA (PubMed:8945517, PubMed:17626046, PubMed:34554261). Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome (PubMed:8945517). Conformational properties of the target DNA sequence rather than specific nucleotides are key determinants of the ORF2p capacity for sequence-specific DNA recognition (PubMed:17626046, PubMed:34554261). Unlike related endonucleases, does not bend the DNA helix but causes compression near the cleavage site (PubMed:34554261). {ECO:0000269|PubMed:17626046, ECO:0000269|PubMed:34554261, ECO:0000269|PubMed:7516468, ECO:0000269|PubMed:8945517, ECO:0000269|PubMed:9140393}.	MISCELLANEOUS: Long interspersed element-1/LINE-1/L1 retrotransposons are present in more than 500'000 full (6 kb) or truncated copies in the human genome. Most of them are inactive but one estimate is that 80 to 100 of those elements could be transcribed, translated and active in any individual. An active LINE-1 encodes for 2 proteins translated from a single RNA containing two non-overlapping ORFs, ORF1 and ORF2. ORF2p is described in this entry as a representative of all ORF2p potentially expressed by active elements. ORF1p is described in the related entry AC Q9UN81.; MISCELLANEOUS: Insertions of LINE-1 (L1) retrotransposons can occur frequently at CRISPR/Cas9 editing sites. The reverse transcriptase activity of ORF2p mediates L1 insertions into CRISPR/Cas9-initiated double-strand breaks (DSB). De novo L1 insertions are rare during genome editing by prime editors and by cytidine or adenine base editors, consistent with their reduced DSB formation. {ECO:0000269|PubMed:35760782}.	DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; retrotransposition [GO:0032197]		metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA-directed DNA polymerase activity [GO:0003964]; type II site-specific deoxyribonuclease activity [GO:0009036]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA-directed DNA polymerase activity [GO:0003964]; type II site-specific deoxyribonuclease activity [GO:0009036]; DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; retrotransposition [GO:0032197]	
O00391	reviewed	QSOX1_HUMAN	Sulfhydryl oxidase 1 (hQSOX) (EC 1.8.3.2) (Quiescin Q6)	QSOX1 QSCN6 UNQ2520/PRO6013	Homo sapiens (Human)	747	FUNCTION: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277). {ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:18393449, ECO:0000269|PubMed:22801504, ECO:0000269|PubMed:23704371, ECO:0000269|PubMed:23867277, ECO:0000269|PubMed:30367560}.	MISCELLANEOUS: 'Quiescin Q6' means that it was the sixth clone to be found at a higher level of expression in quiescent fibroblasts. {ECO:0000305}.	extracellular matrix assembly [GO:0085029]; negative regulation of macroautophagy [GO:0016242]; protein folding [GO:0006457]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; platelet alpha granule lumen [GO:0031093]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	FAD binding [GO:0071949]; flavin-dependent sulfhydryl oxidase activity [GO:0016971]; protein disulfide isomerase activity [GO:0003756]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; platelet alpha granule lumen [GO:0031093]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; FAD binding [GO:0071949]; flavin-dependent sulfhydryl oxidase activity [GO:0016971]; protein disulfide isomerase activity [GO:0003756]; extracellular matrix assembly [GO:0085029]; negative regulation of macroautophagy [GO:0016242]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:23704371}; Single-pass membrane protein {ECO:0000305|PubMed:17331072}. Secreted {ECO:0000269|PubMed:29757379}. Note=A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor. {ECO:0000305|PubMed:29757379}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:10708601}. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells. {ECO:0000269|PubMed:10708601}.
O00399	reviewed	DCTN6_HUMAN	Dynactin subunit 6 (Dynactin subunit p27) (Protein WS-3)	DCTN6 WS3	Homo sapiens (Human)	190	FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000269|PubMed:23455152}.		mitotic spindle organization [GO:0007052]	centrosome [GO:0005813]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; kinetochore [GO:0000776]	dynein complex binding [GO:0070840]	centrosome [GO:0005813]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; kinetochore [GO:0000776]; dynein complex binding [GO:0070840]; mitotic spindle organization [GO:0007052]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:D0G6S1}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:23455152}.
O00400	reviewed	ACATN_HUMAN	Acetyl-coenzyme A transporter 1 (AT-1) (Acetyl-CoA transporter 1) (Solute carrier family 33 member 1)	SLC33A1 ACATN AT1	Homo sapiens (Human)	549	FUNCTION: Acetyl-CoA transporter that mediates active acetyl-CoA import through the endoplasmic reticulum (ER) membrane into the ER lumen where specific ER-based acetyl-CoA:lysine acetyltransferases are responsible for the acetylation of ER-based protein substrates, such as BACE1 (PubMed:24828632, PubMed:20826464). Necessary for O-acetylation of gangliosides (PubMed:9096318). {ECO:0000269|PubMed:20826464, ECO:0000269|PubMed:24828632, ECO:0000269|PubMed:25402622, ECO:0000269|PubMed:9096318}.		acetyl-CoA transmembrane transport [GO:0035348]; transmembrane transport [GO:0055085]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	acetyl-CoA transmembrane transporter activity [GO:0008521]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; acetyl-CoA transmembrane transporter activity [GO:0008521]; protein homodimerization activity [GO:0042803]; acetyl-CoA transmembrane transport [GO:0035348]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20826464, ECO:0000269|PubMed:24828632}; Multi-pass membrane protein {ECO:0000255}.
O00401	reviewed	WASL_HUMAN	Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)	WASL	Homo sapiens (Human)	505	FUNCTION: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:9422512, PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:9422512, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742). {ECO:0000250|UniProtKB:Q91YD9, ECO:0000269|PubMed:16767080, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:22847007, ECO:0000269|PubMed:22921828, ECO:0000269|PubMed:9422512}.		actin filament polymerization [GO:0030041]; actin polymerization or depolymerization [GO:0008154]; cell division [GO:0051301]; dendritic spine morphogenesis [GO:0060997]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of membrane tubulation [GO:1903526]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; protein-containing complex localization [GO:0031503]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; response to bacterium [GO:0009617]; spindle localization [GO:0051653]; vesicle budding from membrane [GO:0006900]; vesicle organization [GO:0016050]; vesicle transport along actin filament [GO:0030050]	actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; GTPase regulator activity [GO:0030695]; microtubule binding [GO:0008017]	actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; GTPase regulator activity [GO:0030695]; microtubule binding [GO:0008017]; actin filament polymerization [GO:0030041]; actin polymerization or depolymerization [GO:0008154]; cell division [GO:0051301]; dendritic spine morphogenesis [GO:0060997]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of membrane tubulation [GO:1903526]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; protein-containing complex localization [GO:0031503]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; response to bacterium [GO:0009617]; spindle localization [GO:0051653]; vesicle budding from membrane [GO:0006900]; vesicle organization [GO:0016050]; vesicle transport along actin filament [GO:0030050]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9422512}. Nucleus {ECO:0000269|PubMed:16767080}. Cytoplasm {ECO:0000250|UniProtKB:Q91YD9}. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity). Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q91YD9}.
O00408	reviewed	PDE2A_HUMAN	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)	PDE2A	Homo sapiens (Human)	941	FUNCTION: cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:9210593, PubMed:29392776, PubMed:15938621). Has a higher efficiency with cGMP compared to cAMP (PubMed:15938621). Plays a role in cell growth and migration (PubMed:24705027). {ECO:0000269|PubMed:15938621, ECO:0000269|PubMed:24705027, ECO:0000269|PubMed:29392776, ECO:0000269|PubMed:9210593}.; FUNCTION: [Isoform PDE2A2]: Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107). {ECO:0000250|UniProtKB:Q922S4, ECO:0000269|PubMed:28463107}.	MISCELLANEOUS: [Isoform PDE2A1]: Soluble form. {ECO:0000305}.; MISCELLANEOUS: [Isoform PDE2A2]: Contains a transit peptide at positions 1-17. {ECO:0000305}.	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; aorta development [GO:0035904]; cAMP-mediated signaling [GO:0019933]; cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to xenobiotic stimulus [GO:0071466]; cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; establishment of endothelial barrier [GO:0061028]; heart valve development [GO:0003170]; monocyte differentiation [GO:0030224]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of vascular permeability [GO:0043117]; regulation of cAMP-mediated signaling [GO:0043949]; regulation of cGMP-mediated signaling [GO:0010752]; regulation of mitochondrion organization [GO:0010821]; ventricular septum development [GO:0003281]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301]; protein homodimerization activity [GO:0042803]; TPR domain binding [GO:0030911]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301]; protein homodimerization activity [GO:0042803]; TPR domain binding [GO:0030911]; zinc ion binding [GO:0008270]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; aorta development [GO:0035904]; cAMP-mediated signaling [GO:0019933]; cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to xenobiotic stimulus [GO:0071466]; cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; establishment of endothelial barrier [GO:0061028]; heart valve development [GO:0003170]; monocyte differentiation [GO:0030224]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of vascular permeability [GO:0043117]; regulation of cAMP-mediated signaling [GO:0043949]; regulation of cGMP-mediated signaling [GO:0010752]; regulation of mitochondrion organization [GO:0010821]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: [Isoform PDE2A3]: Cell membrane {ECO:0000269|PubMed:19632989, ECO:0000269|PubMed:28463107}; Lipid-anchor {ECO:0000269|PubMed:19632989}.; SUBCELLULAR LOCATION: [Isoform PDE2A2]: Mitochondrion matrix {ECO:0000250|UniProtKB:Q922S4}. Mitochondrion inner membrane {ECO:0000269|PubMed:28463107}. Mitochondrion outer membrane {ECO:0000269|PubMed:28463107}.; SUBCELLULAR LOCATION: [Isoform PDE2A1]: Cytoplasm {ECO:0000269|PubMed:19632989, ECO:0000269|PubMed:28463107}.; SUBCELLULAR LOCATION: [Isoform 5]: Mitochondrion {ECO:0000305}.
O00409	reviewed	FOXN3_HUMAN	Forkhead box protein N3 (Checkpoint suppressor 1)	FOXN3 C14orf116 CHES1	Homo sapiens (Human)	490	FUNCTION: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). {ECO:0000269|PubMed:16102918}.		craniofacial suture morphogenesis [GO:0097094]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]	chromatin [GO:0000785]; nucleus [GO:0005634]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	chromatin [GO:0000785]; nucleus [GO:0005634]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; craniofacial suture morphogenesis [GO:0097094]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O00410	reviewed	IPO5_HUMAN	Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)	IPO5 KPNB3 RANBP5	Homo sapiens (Human)	1097	FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:9687515, PubMed:11682607). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000250|UniProtKB:Q8BKC5, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9687515}.		cellular response to amino acid stimulus [GO:0071230]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus [GO:0006606]; ribosomal protein import into nucleus [GO:0006610]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GTPase inhibitor activity [GO:0005095]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; GTPase inhibitor activity [GO:0005095]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; cellular response to amino acid stimulus [GO:0071230]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus [GO:0006606]; ribosomal protein import into nucleus [GO:0006610]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.
O00411	reviewed	RPOM_HUMAN	DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)	POLRMT	Homo sapiens (Human)	1230	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163, PubMed:33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603). Has DNA primase activity (PubMed:18685103, PubMed:33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed:18685103, PubMed:33602924). {ECO:0000269|PubMed:18685103, ECO:0000269|PubMed:21278163, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:33602924}.		mitochondrial transcription [GO:0006390]; transcription initiation at mitochondrial promoter [GO:0006391]	mitochondrial DNA-directed RNA polymerase complex [GO:0034245]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	3'-5'-RNA exonuclease activity [GO:0000175]; DNA primase activity [GO:0003896]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; mitochondrial promoter sequence-specific DNA binding [GO:0001018]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]	mitochondrial DNA-directed RNA polymerase complex [GO:0034245]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; 3'-5'-RNA exonuclease activity [GO:0000175]; DNA primase activity [GO:0003896]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; mitochondrial promoter sequence-specific DNA binding [GO:0001018]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; mitochondrial transcription [GO:0006390]; transcription initiation at mitochondrial promoter [GO:0006391]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:29445193}.
O00418	reviewed	EF2K_HUMAN	Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase)	EEF2K	Homo sapiens (Human)	725	FUNCTION: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}.		cellular response to anoxia [GO:0071454]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to insulin stimulus [GO:0032869]; myosin II filament disassembly [GO:0031037]; negative regulation of apoptotic process [GO:0043066]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of endocytosis [GO:0045807]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of protein autophosphorylation [GO:0031952]; regulation of translation at postsynapse [GO:0140245]; response to ischemia [GO:0002931]; response to prolactin [GO:1990637]; translational elongation [GO:0006414]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; elongation factor-2 kinase activity [GO:0004686]; protein kinase activity [GO:0004672]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; elongation factor-2 kinase activity [GO:0004686]; protein kinase activity [GO:0004672]; translation factor activity, RNA binding [GO:0008135]; cellular response to anoxia [GO:0071454]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to insulin stimulus [GO:0032869]; myosin II filament disassembly [GO:0031037]; negative regulation of apoptotic process [GO:0043066]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of endocytosis [GO:0045807]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of protein autophosphorylation [GO:0031952]; regulation of translation at postsynapse [GO:0140245]; response to ischemia [GO:0002931]; response to prolactin [GO:1990637]; translational elongation [GO:0006414]	
O00421	reviewed	CCRL2_HUMAN	C-C chemokine receptor-like 2 (Chemokine receptor CCR11) (Chemokine receptor X) (Putative MCP-1 chemokine receptor)	CCRL2 CCR11 CCR6 CKRX CRAM HCR	Homo sapiens (Human)	344	FUNCTION: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.	MISCELLANEOUS: It was initially reported that CCRL2 responds functionally to CCL2, CCL5, CCL7, and CCL8 via intracellular calcium mobilization and transwell chemotaxis although no evidence for a direct ligand-receptor interaction was provided in this report. These results are now controversial, and other studies failed to confirm CCRL2 recognition and transwell chemotaxis of these chemokines or a series of other CC- and CXC-chemokines using CCRL2-transfected cells (PubMed:15188357). {ECO:0000305|PubMed:15188357}.	calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; CCR chemokine receptor binding [GO:0048020]; chemokine receptor activity [GO:0004950]; chemokine receptor binding [GO:0042379]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; CCR chemokine receptor binding [GO:0048020]; chemokine receptor activity [GO:0004950]; chemokine receptor binding [GO:0042379]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:20002784}; Multi-pass membrane protein {ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:20002784}.
O00422	reviewed	SAP18_HUMAN	Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18)	SAP18 GIG38	Homo sapiens (Human)	153	FUNCTION: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. {ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:20966198, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:9150135}.		mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380]	ASAP complex [GO:0061574]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]	ASAP complex [GO:0061574]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16314458}. Cytoplasm {ECO:0000269|PubMed:16314458}. Nucleus speckle {ECO:0000269|PubMed:20966198}. Note=Shuttles between the nucleus and the cytoplasm (PubMed:16314458). Colocalizes with ACIN1 and SRSF2 in nuclear speckles (PubMed:20966198). {ECO:0000269|PubMed:16314458, ECO:0000269|PubMed:20966198}.
O00423	reviewed	EMAL1_HUMAN	Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1)	EML1 EMAP1 EMAPL EMAPL1	Homo sapiens (Human)	815	FUNCTION: Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. {ECO:0000250|UniProtKB:Q05BC3}.		brain development [GO:0007420]; hematopoietic progenitor cell differentiation [GO:0002244]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; neuroblast proliferation [GO:0007405]	cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; perinuclear region of cytoplasm [GO:0048471]	calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631]	cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631]; brain development [GO:0007420]; hematopoietic progenitor cell differentiation [GO:0002244]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; neuroblast proliferation [GO:0007405]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q05BC3}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q05BC3}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24859200, ECO:0000269|PubMed:25740311}. Note=Detected in cytoplasmic punctae. Co-localizes with microtubules (PubMed:24859200, PubMed:25740311). Enriched in perinuclear regions during interphase and in the region of spindle microtubules during metaphase. Enriched at the midzone during telophase and cytokinesis. Detected at growth cones in neurons (By similarity). {ECO:0000250|UniProtKB:Q05BC3, ECO:0000269|PubMed:24859200, ECO:0000269|PubMed:25740311}.
O00425	reviewed	IF2B3_HUMAN	Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)	IGF2BP3 IMP3 KOC1 VICKZ3	Homo sapiens (Human)	579	FUNCTION: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}.	MISCELLANEOUS: Autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas.	anatomical structure morphogenesis [GO:0009653]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA transport [GO:0051028]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; regulation of cytokine production [GO:0001817]; regulation of gene expression [GO:0010468]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]	mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182]; anatomical structure morphogenesis [GO:0009653]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA transport [GO:0051028]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; regulation of cytokine production [GO:0001817]; regulation of gene expression [GO:0010468]; translation [GO:0006412]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, P-body {ECO:0000269|PubMed:29476152}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29476152}. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.
O00429	reviewed	DNM1L_HUMAN	Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1)	DNM1L DLP1 DRP1	Homo sapiens (Human)	736	FUNCTION: Functions in mitochondrial and peroxisomal division (PubMed:9570752, PubMed:9786947, PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17553808, PubMed:17460227, PubMed:18695047, PubMed:18838687, PubMed:19638400, PubMed:19411255, PubMed:19342591, PubMed:23921378, PubMed:23283981, PubMed:23530241, PubMed:29478834, PubMed:32484300, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23921378, PubMed:23283981, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:9570752, PubMed:20688057, PubMed:23792689). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.		calcium ion transport [GO:0006816]; endocytosis [GO:0006897]; heart contraction [GO:0060047]; intracellular distribution of mitochondria [GO:0048312]; localization [GO:0051179]; membrane fusion [GO:0061025]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial membrane fission [GO:0090149]; mitochondrion morphogenesis [GO:0070584]; mitochondrion organization [GO:0007005]; mitocytosis [GO:0160040]; necroptotic process [GO:0070266]; peroxisome fission [GO:0016559]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein secretion [GO:0050714]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein complex oligomerization [GO:0051259]; protein localization to mitochondrion [GO:0070585]; protein-containing complex assembly [GO:0065003]; regulation of ATP metabolic process [GO:1903578]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of gene expression [GO:0010468]; regulation of mitochondrion organization [GO:0010821]; regulation of peroxisome organization [GO:1900063]; release of cytochrome c from mitochondria [GO:0001836]; rhythmic process [GO:0048511]	brush border [GO:0005903]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; synaptic vesicle membrane [GO:0030672]	GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625]	brush border [GO:0005903]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; synaptic vesicle membrane [GO:0030672]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625]; calcium ion transport [GO:0006816]; endocytosis [GO:0006897]; heart contraction [GO:0060047]; intracellular distribution of mitochondria [GO:0048312]; localization [GO:0051179]; membrane fusion [GO:0061025]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial membrane fission [GO:0090149]; mitochondrion morphogenesis [GO:0070584]; mitochondrion organization [GO:0007005]; mitocytosis [GO:0160040]; necroptotic process [GO:0070266]; peroxisome fission [GO:0016559]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein secretion [GO:0050714]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein complex oligomerization [GO:0051259]; protein localization to mitochondrion [GO:0070585]; protein-containing complex assembly [GO:0065003]; regulation of ATP metabolic process [GO:1903578]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of gene expression [GO:0010468]; regulation of mitochondrion organization [GO:0010821]; regulation of peroxisome organization [GO:1900063]; release of cytochrome c from mitochondria [GO:0001836]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Golgi apparatus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane {ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:28969390}; Peripheral membrane protein. Peroxisome. Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O35303}. Note=Mainly cytosolic. Recruited by RALA and RALBP1 to mitochondrion during mitosis (PubMed:21822277). Translocated to the mitochondrial membrane through O-GlcNAcylation and interaction with FIS1. Colocalized with MARCHF5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Recruited to the mitochondrial outer membrane by interaction with MIEF1. Mitochondrial recruitment is inhibited by C11orf65/MFI (By similarity). Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex (By similarity). Binds to phospholipid membranes (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:21822277}.
O00442	reviewed	RTCA_HUMAN	RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) (RTC domain-containing protein 1)	RTCA RPC RPC1 RTC1 RTCD1	Homo sapiens (Human)	366	FUNCTION: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (PubMed:9184239). The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product (PubMed:9184239). Likely functions in some aspects of cellular RNA processing (PubMed:9184239, PubMed:25961792). Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury (PubMed:25961792). {ECO:0000269|PubMed:25961792, ECO:0000269|PubMed:9184239}.		RNA processing [GO:0006396]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; RNA binding [GO:0003723]; RNA-3'-phosphate cyclase activity [GO:0003963]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; RNA binding [GO:0003723]; RNA-3'-phosphate cyclase activity [GO:0003963]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:9184239}.
O00443	reviewed	P3C2A_HUMAN	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha)	PIK3C2A	Homo sapiens (Human)	1686	FUNCTION: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}.		clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; exocytosis [GO:0006887]; insulin receptor signaling pathway [GO:0008286]; membrane organization [GO:0061024]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of autophagy [GO:0010508]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; vascular associated smooth muscle contraction [GO:0014829]	clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]	clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]; clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; exocytosis [GO:0006887]; insulin receptor signaling pathway [GO:0008286]; membrane organization [GO:0061024]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of autophagy [GO:0010508]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; vascular associated smooth muscle contraction [GO:0014829]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:17038310}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:11239472}. Nucleus {ECO:0000269|PubMed:11606566}. Cytoplasm {ECO:0000269|PubMed:11606566, ECO:0000269|PubMed:14563213}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:11239472}. Note=Inserts preferentially into membranes containing PtdIns(4,5)P2 (PubMed:17038310). Associated with RNA-containing structures (PubMed:11606566). {ECO:0000269|PubMed:11606566, ECO:0000269|PubMed:17038310}.
O00444	reviewed	PLK4_HUMAN	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)	PLK4 SAK STK18	Homo sapiens (Human)	970	FUNCTION: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}.		centriole replication [GO:0007099]; cilium assembly [GO:0060271]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; positive regulation of centriole replication [GO:0046601]; protein phosphorylation [GO:0006468]; trophoblast giant cell differentiation [GO:0060707]	centriole [GO:0005814]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; deuterosome [GO:0098536]; nucleolus [GO:0005730]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099]; XY body [GO:0001741]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centriole [GO:0005814]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; deuterosome [GO:0098536]; nucleolus [GO:0005730]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099]; XY body [GO:0001741]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; centriole replication [GO:0007099]; cilium assembly [GO:0060271]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; positive regulation of centriole replication [GO:0046601]; protein phosphorylation [GO:0006468]; trophoblast giant cell differentiation [GO:0060707]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27796307}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q64702}. Cleavage furrow {ECO:0000250|UniProtKB:Q64702}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30804208, ECO:0000269|PubMed:32433990}. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.
O00445	reviewed	SYT5_HUMAN	Synaptotagmin-5 (Synaptotagmin V) (SytV)	SYT5	Homo sapiens (Human)	386	FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity). {ECO:0000250}.		calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488]	axon [GO:0030424]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; neuronal cell body [GO:0043025]; neuronal dense core vesicle membrane [GO:0099012]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; proximal neuron projection [GO:1990769]; recycling endosome membrane [GO:0055038]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; syntaxin binding [GO:0019905]	axon [GO:0030424]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; neuronal cell body [GO:0043025]; neuronal dense core vesicle membrane [GO:0099012]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; proximal neuron projection [GO:1990769]; recycling endosome membrane [GO:0055038]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; syntaxin binding [GO:0019905]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=In mast cells, localizes to the endocytic recycling compartment. {ECO:0000250}.
O00451	reviewed	GFRA2_HUMAN	GDNF family receptor alpha-2 (GDNF receptor alpha-2) (GDNFR-alpha-2) (GFR-alpha-2) (GDNF receptor beta) (GDNFR-beta) (Neurturin receptor alpha) (NRTNR-alpha) (NTNR-alpha) (RET ligand 2) (TGF-beta-related neurotrophic factor receptor 2)	GFRA2 GDNFRB RETL2 TRNR2	Homo sapiens (Human)	464	FUNCTION: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.; FUNCTION: [Isoform 2]: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3. {ECO:0000250|UniProtKB:O08842}.		nervous system development [GO:0007399]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	external side of plasma membrane [GO:0009897]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	glial cell-derived neurotrophic factor receptor activity [GO:0016167]	external side of plasma membrane [GO:0009897]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; glial cell-derived neurotrophic factor receptor activity [GO:0016167]; nervous system development [GO:0007399]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
O00453	reviewed	LST1_HUMAN	Leukocyte-specific transcript 1 protein (Protein B144)	LST1 B144	Homo sapiens (Human)	97	FUNCTION: Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation. {ECO:0000269|PubMed:10706707, ECO:0000269|PubMed:11478849}.		anatomical structure morphogenesis [GO:0009653]; cell morphogenesis [GO:0000902]; dendrite development [GO:0016358]; immune response [GO:0006955]; negative regulation of lymphocyte proliferation [GO:0050672]; regulation of cell shape [GO:0008360]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; anatomical structure morphogenesis [GO:0009653]; cell morphogenesis [GO:0000902]; dendrite development [GO:0016358]; immune response [GO:0006955]; negative regulation of lymphocyte proliferation [GO:0050672]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Note=Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.
O00459	reviewed	P85B_HUMAN	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)	PIK3R2	Homo sapiens (Human)	728	FUNCTION: Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). {ECO:0000250|UniProtKB:O08908, ECO:0000269|PubMed:23604317}.		B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; intracellular glucose homeostasis [GO:0001678]; negative regulation of MAPK cascade [GO:0043409]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of cell adhesion [GO:0045785]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; regulation of actin filament polymerization [GO:0030833]; regulation of autophagy [GO:0010506]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of stress fiber assembly [GO:0051492]; response to endoplasmic reticulum stress [GO:0034976]; T cell differentiation [GO:0030217]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphotyrosine residue binding [GO:0001784]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; receptor tyrosine kinase binding [GO:0030971]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphotyrosine residue binding [GO:0001784]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; receptor tyrosine kinase binding [GO:0030971]; B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; intracellular glucose homeostasis [GO:0001678]; negative regulation of MAPK cascade [GO:0043409]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of cell adhesion [GO:0045785]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; regulation of actin filament polymerization [GO:0030833]; regulation of autophagy [GO:0010506]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of stress fiber assembly [GO:0051492]; response to endoplasmic reticulum stress [GO:0034976]; T cell differentiation [GO:0030217]	
O00461	reviewed	GOLI4_HUMAN	Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa)	GOLIM4 GIMPC GOLPH4 GPP130	Homo sapiens (Human)	696	FUNCTION: Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. {ECO:0000269|PubMed:15331763}.			cis-Golgi network [GO:0005801]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133]		cis-Golgi network [GO:0005801]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome.
O00462	reviewed	MANBA_HUMAN	Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase)	MANBA MANB1	Homo sapiens (Human)	879	FUNCTION: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides. {ECO:0000305|PubMed:12890191, ECO:0000305|PubMed:30552791}.		glycoprotein catabolic process [GO:0006516]; oligosaccharide catabolic process [GO:0009313]; protein modification process [GO:0036211]	azurophil granule membrane [GO:0035577]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]	beta-mannosidase activity [GO:0004567]; mannose binding [GO:0005537]	azurophil granule membrane [GO:0035577]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; beta-mannosidase activity [GO:0004567]; mannose binding [GO:0005537]; glycoprotein catabolic process [GO:0006516]; oligosaccharide catabolic process [GO:0009313]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Lysosome {ECO:0000305}.
O00463	reviewed	TRAF5_HUMAN	TNF receptor-associated factor 5 (RING finger protein 84)	TRAF5 RNF84	Homo sapiens (Human)	557	FUNCTION: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. {ECO:0000269|PubMed:15121867}.		apoptotic process [GO:0006915]; interleukin-17-mediated signaling pathway [GO:0097400]; mRNA stabilization [GO:0048255]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]; signal transduction involved in regulation of gene expression [GO:0023019]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	CD40 receptor complex [GO:0035631]; centrosome [GO:0005813]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]	identical protein binding [GO:0042802]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; centrosome [GO:0005813]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; interleukin-17-mediated signaling pathway [GO:0097400]; mRNA stabilization [GO:0048255]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]; signal transduction involved in regulation of gene expression [GO:0023019]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:15121867}. Cytoplasm, cytosol {ECO:0000269|PubMed:15121867}.
O00468	reviewed	AGRIN_HUMAN	Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]	AGRN AGRIN	Homo sapiens (Human)	2068	FUNCTION: [Isoform 1]: Heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.; FUNCTION: [Isoform 2]: Transmembrane form that is the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases.; FUNCTION: Isoform 1, isoform 4 and isoform 5: neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering. Isoform 5, agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the 'z' isoforms.; FUNCTION: Isoform 3 and isoform 6: lack any 'z' insert, are muscle-specific and may be involved in endothelial cell differentiation.; FUNCTION: [Agrin N-terminal 110 kDa subunit]: Is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity). {ECO:0000250, ECO:0000269|PubMed:19631309, ECO:0000269|PubMed:21969364}.; FUNCTION: [Agrin C-terminal 22 kDa fragment]: This released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia.	MISCELLANEOUS: Cleaved C-terminal fragments may be used as a biomarker for sarcopenia, age-related progressive loss of skeletal muscle. {ECO:0000305|PubMed:22683512}.; MISCELLANEOUS: [Isoform 2]: Produced by usage of an alternative first exon. {ECO:0000305}.	clustering of voltage-gated sodium channels [GO:0045162]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; neuromuscular junction development [GO:0007528]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of synaptic assembly at neuromuscular junction [GO:0045887]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; synapse organization [GO:0050808]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; synapse [GO:0045202]	calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; dystroglycan binding [GO:0002162]; heparan sulfate proteoglycan binding [GO:0043395]; laminin binding [GO:0043236]; sialic acid binding [GO:0033691]; structural constituent of cytoskeleton [GO:0005200]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; dystroglycan binding [GO:0002162]; heparan sulfate proteoglycan binding [GO:0043395]; laminin binding [GO:0043236]; sialic acid binding [GO:0033691]; structural constituent of cytoskeleton [GO:0005200]; clustering of voltage-gated sodium channels [GO:0045162]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; neuromuscular junction development [GO:0007528]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of synaptic assembly at neuromuscular junction [GO:0045887]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}. Note=Synaptic basal lamina at the neuromuscular junction. {ECO:0000250|UniProtKB:P31696}.; SUBCELLULAR LOCATION: [Isoform 2]: Synapse {ECO:0000250|UniProtKB:A2ASQ1}. Cell membrane {ECO:0000250|UniProtKB:A2ASQ1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:A2ASQ1}.
O00469	reviewed	PLOD2_HUMAN	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2)	PLOD2	Homo sapiens (Human)	737	FUNCTION: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. {ECO:0000250|UniProtKB:P24802}.		hydroxylysine biosynthetic process [GO:0046947]; peptidyl-lysine hydroxylation [GO:0017185]; protein modification process [GO:0036211]; response to hypoxia [GO:0001666]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; rough endoplasmic reticulum membrane [GO:0030867]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-lysine 5-dioxygenase activity [GO:0008475]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; rough endoplasmic reticulum membrane [GO:0030867]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-lysine 5-dioxygenase activity [GO:0008475]; hydroxylysine biosynthetic process [GO:0046947]; peptidyl-lysine hydroxylation [GO:0017185]; protein modification process [GO:0036211]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
O00470	reviewed	MEIS1_HUMAN	Homeobox protein Meis1	MEIS1	Homo sapiens (Human)	390	FUNCTION: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. {ECO:0000269|PubMed:12609849}.		angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; cell growth involved in cardiac muscle cell development [GO:0061049]; definitive hemopoiesis [GO:0060216]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; hemopoiesis [GO:0030097]; lens morphogenesis in camera-type eye [GO:0002089]; locomotory behavior [GO:0007626]; megakaryocyte development [GO:0035855]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; cell growth involved in cardiac muscle cell development [GO:0061049]; definitive hemopoiesis [GO:0060216]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; hemopoiesis [GO:0030097]; lens morphogenesis in camera-type eye [GO:0002089]; locomotory behavior [GO:0007626]; megakaryocyte development [GO:0035855]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
O00471	reviewed	EXOC5_HUMAN	Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10)	EXOC5 SEC10 SEC10L1	Homo sapiens (Human)	708	FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.		epithelial cell apoptotic process [GO:1904019]; establishment of planar polarity [GO:0001736]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; non-motile cilium assembly [GO:1905515]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; midbody [GO:0030496]	small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; midbody [GO:0030496]; small GTPase binding [GO:0031267]; epithelial cell apoptotic process [GO:1904019]; establishment of planar polarity [GO:0001736]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; non-motile cilium assembly [GO:1905515]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9119050}. Midbody {ECO:0000269|PubMed:18756269}. Note=Localization at the midbody requires the presence of RALA, EXOC2 and EXOC3. {ECO:0000269|PubMed:18756269}.
O00472	reviewed	ELL2_HUMAN	RNA polymerase II elongation factor ELL2	ELL2	Homo sapiens (Human)	640	FUNCTION: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}.		positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription elongation by RNA polymerase II [GO:0006368]	nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]	cis-regulatory region sequence-specific DNA binding [GO:0000987]	nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus.
O00476	reviewed	NPT4_HUMAN	Sodium-dependent phosphate transport protein 4 (Na(+)/PI cotransporter 4) (NPT4) (Sodium/phosphate cotransporter 4) (Solute carrier family 17 member 3)	SLC17A3 NPT4	Homo sapiens (Human)	420	FUNCTION: [Isoform 2]: Transports organic anions in a voltage-driven, multispecific, manner, on the apical side of renal proximal tubule (PubMed:20810651). In particular, participates in the secretion of urate from the cell into the lumen (PubMed:20810651). Urate is the end product of purine metabolism (PubMed:20810651). May have roles in the metabolism and secretion of estrone sulfate, estradiol-17-beta-glucuronide, ochratoxin A, as wells as drugs such as bumetanide (PubMed:20810651). {ECO:0000269|PubMed:20810651, ECO:0000303|PubMed:20810651}.		glucose-6-phosphate transport [GO:0015760]; monoatomic anion transport [GO:0006820]; monoatomic ion transmembrane transport [GO:0034220]; organic anion transport [GO:0015711]; phosphate ion transport [GO:0006817]; sodium ion transport [GO:0006814]; urate metabolic process [GO:0046415]; urate transport [GO:0015747]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	efflux transmembrane transporter activity [GO:0015562]; organic anion transmembrane transporter activity [GO:0008514]; sodium:phosphate symporter activity [GO:0005436]; toxin transmembrane transporter activity [GO:0019534]; urate transmembrane transporter activity [GO:0015143]; voltage-gated monoatomic anion channel activity [GO:0008308]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; efflux transmembrane transporter activity [GO:0015562]; organic anion transmembrane transporter activity [GO:0008514]; sodium:phosphate symporter activity [GO:0005436]; toxin transmembrane transporter activity [GO:0019534]; urate transmembrane transporter activity [GO:0015143]; voltage-gated monoatomic anion channel activity [GO:0008308]; xenobiotic transmembrane transporter activity [GO:0042910]; glucose-6-phosphate transport [GO:0015760]; monoatomic anion transport [GO:0006820]; monoatomic ion transmembrane transport [GO:0034220]; organic anion transport [GO:0015711]; phosphate ion transport [GO:0006817]; sodium ion transport [GO:0006814]; urate metabolic process [GO:0046415]; urate transport [GO:0015747]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15505377}; Multi-pass membrane protein {ECO:0000269|PubMed:15505377}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:20810651}; Multi-pass membrane protein {ECO:0000269|PubMed:20810651}.
O00478	reviewed	BT3A3_HUMAN	Butyrophilin subfamily 3 member A3	BTN3A3 BTF3	Homo sapiens (Human)	584	FUNCTION: Plays a role in T-cell responses in the adaptive immune response. {ECO:0000269|PubMed:22767497}.		regulation of cytokine production [GO:0001817]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor binding [GO:0005102]; regulation of cytokine production [GO:0001817]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}; Single-pass type I membrane protein {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}.
O00481	reviewed	BT3A1_HUMAN	Butyrophilin subfamily 3 member A1 (CD antigen CD277)	BTN3A1 BTF5	Homo sapiens (Human)	513	FUNCTION: Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. {ECO:0000269|PubMed:21113407, ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497, ECO:0000269|PubMed:22846996}.		activated T cell proliferation [GO:0050798]; adaptive immune response [GO:0002250]; positive regulation of cytokine production [GO:0001819]; positive regulation of type II interferon production [GO:0032729]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; signaling receptor binding [GO:0005102]; activated T cell proliferation [GO:0050798]; adaptive immune response [GO:0002250]; positive regulation of cytokine production [GO:0001819]; positive regulation of type II interferon production [GO:0032729]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21113407, ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}; Single-pass type I membrane protein {ECO:0000269|PubMed:21113407, ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}.
O00482	reviewed	NR5A2_HUMAN	Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1)	NR5A2 B1F CPF FTF	Homo sapiens (Human)	541	FUNCTION: Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity). {ECO:0000250|UniProtKB:P45448, ECO:0000269|PubMed:15707893, ECO:0000269|PubMed:15723037, ECO:0000269|PubMed:15897460, ECO:0000269|PubMed:16289203, ECO:0000269|PubMed:20159957}.	MISCELLANEOUS: [Isoform 3]: Does not induce CYP7A promoter activity. {ECO:0000305}.	acinar cell differentiation [GO:0090425]; bile acid metabolic process [GO:0008206]; calcineurin-mediated signaling [GO:0097720]; cellular response to leukemia inhibitory factor [GO:1990830]; cholesterol homeostasis [GO:0042632]; embryo development ending in birth or egg hatching [GO:0009792]; homeostatic process [GO:0042592]; hormone-mediated signaling pathway [GO:0009755]; pancreas morphogenesis [GO:0061113]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of viral genome replication [GO:0045070]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; tissue development [GO:0009888]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; phospholipid binding [GO:0005543]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; phospholipid binding [GO:0005543]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]; acinar cell differentiation [GO:0090425]; bile acid metabolic process [GO:0008206]; calcineurin-mediated signaling [GO:0097720]; cellular response to leukemia inhibitory factor [GO:1990830]; cholesterol homeostasis [GO:0042632]; embryo development ending in birth or egg hatching [GO:0009792]; homeostatic process [GO:0042592]; hormone-mediated signaling pathway [GO:0009755]; pancreas morphogenesis [GO:0061113]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of viral genome replication [GO:0045070]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; tissue development [GO:0009888]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O00483	reviewed	NDUA4_HUMAN	Cytochrome c oxidase subunit NDUFA4 (Complex I-MLRQ) (CI-MLRQ) (NADH-ubiquinone oxidoreductase MLRQ subunit)	NDUFA4	Homo sapiens (Human)	81	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (PubMed:22902835). NDUFA4 is required for complex IV maintenance (PubMed:22902835). {ECO:0000269|PubMed:22902835}.	MISCELLANEOUS: During complex IV purifications dissociates from complex IV upon treatment with standard detergent DDM (decyl beta-D-maltoside) in high concentrations (PubMed:22902835, PubMed:23746447). {ECO:0000305|PubMed:22902835, ECO:0000305|PubMed:23746447}.	cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; positive regulation of cytochrome-c oxidase activity [GO:1904960]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]; protein-containing complex binding [GO:0044877]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; protein-containing complex binding [GO:0044877]; cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; positive regulation of cytochrome-c oxidase activity [GO:1904960]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:23746447, ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
O00487	reviewed	PSDE_HUMAN	26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (26S proteasome-associated PAD1 homolog 1)	PSMD14 POH1	Homo sapiens (Human)	310	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22909820, ECO:0000269|PubMed:9374539}.		double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked deubiquitination [GO:0070536]; regulation of proteasomal protein catabolic process [GO:0061136]; response to ethanol [GO:0045471]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]	endopeptidase activator activity [GO:0061133]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; proteasome binding [GO:0070628]	cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]; endopeptidase activator activity [GO:0061133]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; proteasome binding [GO:0070628]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked deubiquitination [GO:0070536]; regulation of proteasomal protein catabolic process [GO:0061136]; response to ethanol [GO:0045471]; ubiquitin-dependent protein catabolic process [GO:0006511]	
O00488	reviewed	ZN593_HUMAN	Zinc finger protein 593 (Zinc finger protein T86)	ZNF593 ZT86	Homo sapiens (Human)	134	FUNCTION: Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome (PubMed:32669547). Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity (PubMed:9115366). {ECO:0000269|PubMed:9115366, ECO:0000305|PubMed:32669547}.		negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; ribosome biogenesis [GO:0042254]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; preribosome binding [GO:1990275]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; preribosome binding [GO:1990275]; zinc ion binding [GO:0008270]; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Cytoplasm {ECO:0000250|UniProtKB:Q08004}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250|UniProtKB:Q08004}.
O00499	reviewed	BIN1_HUMAN	Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)	BIN1 AMPHL	Homo sapiens (Human)	593	FUNCTION: Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863). {ECO:0000250|UniProtKB:O08839, ECO:0000269|PubMed:24755653, ECO:0000269|PubMed:27179792, ECO:0000269|PubMed:28893863, ECO:0000269|PubMed:8782822}.		cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; lipid tube assembly [GO:0060988]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902960]; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ventricular cardiac muscle cell action potential [GO:1903946]; nucleus localization [GO:0051647]; nucleus organization [GO:0006997]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of endocytosis [GO:0045807]; regulation of cell cycle process [GO:0010564]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of neuron differentiation [GO:0045664]; synaptic vesicle endocytosis [GO:0048488]; T-tubule organization [GO:0033292]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; cerebellar mossy fiber [GO:0044300]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extrinsic component of synaptic vesicle membrane [GO:0098850]; glutamatergic synapse [GO:0098978]; I band [GO:0031674]; lipid tube [GO:0060987]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription repressor complex [GO:0090571]; synaptic vesicle [GO:0008021]; T-tubule [GO:0030315]; varicosity [GO:0043196]; vesicle [GO:0031982]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; clathrin binding [GO:0030276]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; protease binding [GO:0002020]; protein-folding chaperone binding [GO:0051087]; RNA polymerase binding [GO:0070063]; tau protein binding [GO:0048156]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; cerebellar mossy fiber [GO:0044300]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extrinsic component of synaptic vesicle membrane [GO:0098850]; glutamatergic synapse [GO:0098978]; I band [GO:0031674]; lipid tube [GO:0060987]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription repressor complex [GO:0090571]; synaptic vesicle [GO:0008021]; T-tubule [GO:0030315]; varicosity [GO:0043196]; vesicle [GO:0031982]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; clathrin binding [GO:0030276]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; protease binding [GO:0002020]; protein-folding chaperone binding [GO:0051087]; RNA polymerase binding [GO:0070063]; tau protein binding [GO:0048156]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; lipid tube assembly [GO:0060988]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902960]; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ventricular cardiac muscle cell action potential [GO:1903946]; nucleus localization [GO:0051647]; nucleus organization [GO:0006997]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of endocytosis [GO:0045807]; regulation of cell cycle process [GO:0010564]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of neuron differentiation [GO:0045664]; synaptic vesicle endocytosis [GO:0048488]; T-tubule organization [GO:0033292]	SUBCELLULAR LOCATION: [Isoform BIN1]: Nucleus {ECO:0000269|PubMed:8782822}. Cytoplasm {ECO:0000269|PubMed:9182667}. Endosome {ECO:0000250|UniProtKB:O08539}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08839}.; SUBCELLULAR LOCATION: [Isoform IIA]: Cytoplasm {ECO:0000269|PubMed:9182667}.
O00501	reviewed	CLD5_HUMAN	Claudin-5 (Transmembrane protein deleted in VCFS) (TMDVCF)	CLDN5 AWAL TMVCF	Homo sapiens (Human)	218	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; cell-cell junction assembly [GO:0007043]; establishment of blood-retinal barrier [GO:1990963]; face morphogenesis [GO:0060325]; learning [GO:0007612]; maintenance of blood-brain barrier [GO:0035633]; myelination [GO:0042552]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; negative regulation of gene expression [GO:0010629]; negative regulation of vascular permeability [GO:0043116]; outflow tract morphogenesis [GO:0003151]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of gene expression [GO:0010628]; positive regulation of protein binding [GO:0032092]; response to ethanol [GO:0045471]; roof of mouth development [GO:0060021]; tight junction assembly [GO:0120192]; transforming growth factor beta receptor signaling pathway [GO:0007179]	apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; cell-cell junction assembly [GO:0007043]; establishment of blood-retinal barrier [GO:1990963]; face morphogenesis [GO:0060325]; learning [GO:0007612]; maintenance of blood-brain barrier [GO:0035633]; myelination [GO:0042552]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; negative regulation of gene expression [GO:0010629]; negative regulation of vascular permeability [GO:0043116]; outflow tract morphogenesis [GO:0003151]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of gene expression [GO:0010628]; positive regulation of protein binding [GO:0032092]; response to ethanol [GO:0045471]; roof of mouth development [GO:0060021]; tight junction assembly [GO:0120192]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
O00505	reviewed	IMA4_HUMAN	Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma)	KPNA3 QIP2	Homo sapiens (Human)	521	FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.		NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606]; protein-containing complex assembly [GO:0065003]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732]	cytosol [GO:0005829]; host cell [GO:0043657]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]	cytosol [GO:0005829]; host cell [GO:0043657]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606]; protein-containing complex assembly [GO:0065003]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:34564892}. Nucleus {ECO:0000269|PubMed:34564892}.
O00506	reviewed	STK25_HUMAN	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1)	STK25 SOK1 YSK1	Homo sapiens (Human)	426	FUNCTION: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. {ECO:0000269|PubMed:15037601}.		axonogenesis [GO:0007409]; establishment of Golgi localization [GO:0051683]; establishment or maintenance of cell polarity [GO:0007163]; Golgi localization [GO:0051645]; Golgi reassembly [GO:0090168]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; positive regulation of axonogenesis [GO:0050772]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to hydrogen peroxide [GO:0042542]; response to oxidative stress [GO:0006979]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; axonogenesis [GO:0007409]; establishment of Golgi localization [GO:0051683]; establishment or maintenance of cell polarity [GO:0007163]; Golgi localization [GO:0051645]; Golgi reassembly [GO:0090168]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; positive regulation of axonogenesis [GO:0050772]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to hydrogen peroxide [GO:0042542]; response to oxidative stress [GO:0006979]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15037601}. Golgi apparatus {ECO:0000269|PubMed:15037601}. Note=Localizes to the Golgi apparatus.
O00507	reviewed	USP9Y_HUMAN	Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC 3.4.19.12) (Deubiquitinating enzyme FAF-Y) (Fat facets protein-related, Y-linked) (Ubiquitin thioesterase FAF-Y) (Ubiquitin-specific protease 9, Y chromosome) (Ubiquitin-specific-processing protease FAF-Y)	USP9Y DFFRY	Homo sapiens (Human)	2555	FUNCTION: May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform Short]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	BMP signaling pathway [GO:0030509]; cell migration [GO:0016477]; protein deubiquitination [GO:0016579]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	co-SMAD binding [GO:0070410]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; co-SMAD binding [GO:0070410]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; BMP signaling pathway [GO:0030509]; cell migration [GO:0016477]; protein deubiquitination [GO:0016579]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O00512	reviewed	BCL9_HUMAN	B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog)	BCL9	Homo sapiens (Human)	1426	FUNCTION: Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}.		canonical Wnt signaling pathway [GO:0060070]; myoblast differentiation [GO:0045445]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell population maintenance [GO:0035019]; transcription by RNA polymerase II [GO:0006366]	beta-catenin-TCF complex [GO:1990907]; cis-Golgi network [GO:0005801]; nucleoplasm [GO:0005654]; sarcoplasm [GO:0016528]	beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713]	beta-catenin-TCF complex [GO:1990907]; cis-Golgi network [GO:0005801]; nucleoplasm [GO:0005654]; sarcoplasm [GO:0016528]; beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713]; canonical Wnt signaling pathway [GO:0060070]; myoblast differentiation [GO:0045445]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell population maintenance [GO:0035019]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
O00519	reviewed	FAAH1_HUMAN	Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1)	FAAH FAAH1	Homo sapiens (Human)	579	FUNCTION: Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:17015445, PubMed:19926788). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:17015445). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:21049984). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity). {ECO:0000250|UniProtKB:O08914, ECO:0000269|PubMed:17015445, ECO:0000269|PubMed:19926788, ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:9122178}.		arachidonic acid metabolic process [GO:0019369]; fatty acid catabolic process [GO:0009062]; monoacylglycerol catabolic process [GO:0052651]; positive regulation of vasoconstriction [GO:0045907]	cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; organelle membrane [GO:0031090]	acylglycerol lipase activity [GO:0047372]; amidase activity [GO:0004040]; fatty acid amide hydrolase activity [GO:0017064]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]	cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; organelle membrane [GO:0031090]; acylglycerol lipase activity [GO:0047372]; amidase activity [GO:0004040]; fatty acid amide hydrolase activity [GO:0017064]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; arachidonic acid metabolic process [GO:0019369]; fatty acid catabolic process [GO:0009062]; monoacylglycerol catabolic process [GO:0052651]; positive regulation of vasoconstriction [GO:0045907]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:17015445}; Single-pass membrane protein {ECO:0000269|PubMed:17015445}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17015445}. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.
O00522	reviewed	KRIT1_HUMAN	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein)	KRIT1 CCM1	Homo sapiens (Human)	736	FUNCTION: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels. May play a role in the regulation of macroautophagy through the down-regulation of the mTOR pathway (PubMed:26417067). {ECO:0000250|UniProtKB:Q6S5J6, ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:20616044, ECO:0000269|PubMed:20668652, ECO:0000269|PubMed:21633110, ECO:0000269|PubMed:23317506, ECO:0000269|PubMed:26417067}.		angiogenesis [GO:0001525]; cell redox homeostasis [GO:0045454]; endothelium development [GO:0003158]; integrin activation [GO:0033622]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; regulation of angiogenesis [GO:0045765]; regulation of establishment of cell polarity [GO:2000114]; small GTPase mediated signal transduction [GO:0007264]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GTPase regulator activity [GO:0030695]; microtubule binding [GO:0008017]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; GTPase regulator activity [GO:0030695]; microtubule binding [GO:0008017]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; angiogenesis [GO:0001525]; cell redox homeostasis [GO:0045454]; endothelium development [GO:0003158]; integrin activation [GO:0033622]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; regulation of angiogenesis [GO:0045765]; regulation of establishment of cell polarity [GO:2000114]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell junction. Note=KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. Association with RAP1 relocalizes KRIT1 from microtubules to cell junction membranes. Translocates from the cytoplasm along microtubules to the cell membrane in a ITGB1BP1-dependent manner.
O00526	reviewed	UPK2_HUMAN	Uroplakin-2 (UP2) (Uroplakin II) (UPII)	UPK2	Homo sapiens (Human)	184	FUNCTION: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity). {ECO:0000250}.		epithelial cell differentiation [GO:0030855]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]		apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; epithelial cell differentiation [GO:0030855]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}.
O00533	reviewed	NCHL1_HUMAN	Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein]	CHL1 CALL	Homo sapiens (Human)	1208	FUNCTION: Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}.		adult locomotory behavior [GO:0008344]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cognition [GO:0050890]; exploration behavior [GO:0035640]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; signal transduction [GO:0007165]	apical part of cell [GO:0045177]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	protease binding [GO:0002020]	apical part of cell [GO:0045177]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protease binding [GO:0002020]; adult locomotory behavior [GO:0008344]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cognition [GO:0050890]; exploration behavior [GO:0035640]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Soluble forms produced by cleavage/shedding also exist. {ECO:0000250}.; SUBCELLULAR LOCATION: [Processed neural cell adhesion molecule L1-like protein]: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
O00541	reviewed	PESC_HUMAN	Pescadillo homolog	PES1	Homo sapiens (Human)	588	FUNCTION: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03028, ECO:0000269|PubMed:16738141, ECO:0000269|PubMed:17189298, ECO:0000269|PubMed:17353269}.		cell population proliferation [GO:0008283]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of cell cycle [GO:0051726]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]	chromosome [GO:0005694]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]	ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]	chromosome [GO:0005694]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; cell population proliferation [GO:0008283]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of cell cycle [GO:0051726]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255|HAMAP-Rule:MF_03028}.
O00548	reviewed	DLL1_HUMAN	Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1)	DLL1 UNQ146/PRO172	Homo sapiens (Human)	723	FUNCTION: Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:11006133). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:11581320). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B-cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (PubMed:11581320). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation through regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. Regulates growth, blood pressure and energy homeostasis (By similarity). {ECO:0000250|UniProtKB:P97677, ECO:0000250|UniProtKB:Q61483, ECO:0000269|PubMed:11006133, ECO:0000269|PubMed:11581320}.		astrocyte development [GO:0014002]; cell differentiation [GO:0030154]; cell fate determination [GO:0001709]; cerebellar molecular layer formation [GO:0021688]; cerebellar Purkinje cell layer structural organization [GO:0021693]; clathrin-dependent endocytosis [GO:0072583]; compartment pattern specification [GO:0007386]; determination of left/right symmetry [GO:0007368]; endothelial tip cell fate specification [GO:0097102]; energy homeostasis [GO:0097009]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; inhibition of neuroepithelial cell differentiation [GO:0002085]; inner ear auditory receptor cell differentiation [GO:0042491]; lateral inhibition [GO:0046331]; left/right axis specification [GO:0070986]; loop of Henle development [GO:0072070]; marginal zone B cell differentiation [GO:0002315]; myeloid cell differentiation [GO:0030099]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal cell differentiation [GO:0045605]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of Notch signaling pathway [GO:0045746]; nephron development [GO:0072006]; neuroepithelial cell differentiation [GO:0060563]; neuron fate specification [GO:0048665]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in arterial endothelial cell fate commitment [GO:0060853]; organ growth [GO:0035265]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endocytosis [GO:0045807]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal tubule development [GO:0072014]; proximal/distal pattern formation [GO:0009954]; regulation of blood pressure [GO:0008217]; regulation of cell adhesion [GO:0030155]; regulation of cell division [GO:0051302]; regulation of growth [GO:0040008]; regulation of neurogenesis [GO:0050767]; regulation of skeletal muscle tissue growth [GO:0048631]; regulation of somitogenesis [GO:0014807]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746]; retina development in camera-type eye [GO:0060041]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal muscle tissue growth [GO:0048630]; skin epidermis development [GO:0098773]; somite specification [GO:0001757]; somitogenesis [GO:0001756]; spinal cord development [GO:0021510]; type B pancreatic cell development [GO:0003323]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; receptor ligand activity [GO:0048018]; scaffold protein binding [GO:0097110]; Tat protein binding [GO:0030957]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; receptor ligand activity [GO:0048018]; scaffold protein binding [GO:0097110]; Tat protein binding [GO:0030957]; astrocyte development [GO:0014002]; cell differentiation [GO:0030154]; cell fate determination [GO:0001709]; cerebellar molecular layer formation [GO:0021688]; cerebellar Purkinje cell layer structural organization [GO:0021693]; clathrin-dependent endocytosis [GO:0072583]; compartment pattern specification [GO:0007386]; determination of left/right symmetry [GO:0007368]; endothelial tip cell fate specification [GO:0097102]; energy homeostasis [GO:0097009]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; inhibition of neuroepithelial cell differentiation [GO:0002085]; inner ear auditory receptor cell differentiation [GO:0042491]; lateral inhibition [GO:0046331]; left/right axis specification [GO:0070986]; loop of Henle development [GO:0072070]; marginal zone B cell differentiation [GO:0002315]; myeloid cell differentiation [GO:0030099]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal cell differentiation [GO:0045605]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of Notch signaling pathway [GO:0045746]; nephron development [GO:0072006]; neuroepithelial cell differentiation [GO:0060563]; neuron fate specification [GO:0048665]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in arterial endothelial cell fate commitment [GO:0060853]; organ growth [GO:0035265]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endocytosis [GO:0045807]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal tubule development [GO:0072014]; proximal/distal pattern formation [GO:0009954]; regulation of blood pressure [GO:0008217]; regulation of cell adhesion [GO:0030155]; regulation of cell division [GO:0051302]; regulation of growth [GO:0040008]; regulation of neurogenesis [GO:0050767]; regulation of skeletal muscle tissue growth [GO:0048631]; regulation of somitogenesis [GO:0014807]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746]; retina development in camera-type eye [GO:0060041]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal muscle tissue growth [GO:0048630]; skin epidermis development [GO:0098773]; somite specification [GO:0001757]; somitogenesis [GO:0001756]; spinal cord development [GO:0021510]; type B pancreatic cell development [GO:0003323]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q61483}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q61483}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q61483}. Membrane raft {ECO:0000250|UniProtKB:Q61483}. Note=Distributed around adherens junction in the apical endfeet through interactions with MAGI1. {ECO:0000250|UniProtKB:Q61483}.
O00555	reviewed	CAC1A_HUMAN	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1)	CACNA1A CACH4 CACN3 CACNL1A4	Homo sapiens (Human)	2506	FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). {ECO:0000250|UniProtKB:P54282, ECO:0000269|PubMed:10049321, ECO:0000269|PubMed:10753886, ECO:0000269|PubMed:11723274, ECO:0000269|PubMed:15293273, ECO:0000269|PubMed:19232643, ECO:0000269|PubMed:24836863, ECO:0000269|PubMed:26716990}.		calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to amyloid-beta [GO:1904645]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]	amyloid-beta binding [GO:0001540]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; syntaxin binding [GO:0019905]; voltage-gated calcium channel activity [GO:0005245]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]; amyloid-beta binding [GO:0001540]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; syntaxin binding [GO:0019905]; voltage-gated calcium channel activity [GO:0005245]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to amyloid-beta [GO:1904645]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10049321, ECO:0000269|PubMed:26716990}; Multi-pass membrane protein {ECO:0000255}.
O00559	reviewed	RCAS1_HUMAN	Receptor-binding cancer antigen expressed on SiSo cells (Cancer-associated surface antigen RCAS1) (Estrogen receptor-binding fragment-associated gene 9 protein)	EBAG9 RCAS1	Homo sapiens (Human)	213	FUNCTION: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. {ECO:0000269|PubMed:12054692, ECO:0000269|PubMed:12138241, ECO:0000269|PubMed:12672804}.	MISCELLANEOUS: May serve as a prognostic marker for cancers such as adenocarcinomas of the lung and breast cancers. It is present and overexpressed in many patients suffering from breast carcinomas, its level of expression correlates with tumor grade, suggesting that it may be involved in cancer immune escape. According to PubMed:12672804, it is however not directly a tumor-associated antigen, but it rather modulates surface expression of tumor-associated O-linked glycan Tn when it is overexpressed, suggesting that it contributes indirectly to the antigenicity of tumor cells.	adaptive immune memory response involving T cells and B cells [GO:0090717]; regulation of cell growth [GO:0001558]; T cell mediated cytotoxicity [GO:0001913]	Golgi membrane [GO:0000139]; secretory granule [GO:0030141]	peptidase activator activity involved in apoptotic process [GO:0016505]	Golgi membrane [GO:0000139]; secretory granule [GO:0030141]; peptidase activator activity involved in apoptotic process [GO:0016505]; adaptive immune memory response involving T cells and B cells [GO:0090717]; regulation of cell growth [GO:0001558]; T cell mediated cytotoxicity [GO:0001913]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12672804}; Single-pass type III membrane protein {ECO:0000269|PubMed:12672804}. Note=According to PubMed:10426319, it also exists as a soluble form which has the same biological activities. The existence of such soluble form is however uncertain.
O00560	reviewed	SDCB1_HUMAN	Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1)	SDCBP MDA9 SYCL	Homo sapiens (Human)	298	FUNCTION: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}.		actin cytoskeleton organization [GO:0030036]; chemical synaptic transmission [GO:0007268]; intracellular signal transduction [GO:0035556]; negative regulation of receptor internalization [GO:0002091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; presynapse assembly [GO:0099054]; protein targeting to membrane [GO:0006612]; proteolysis [GO:0006508]; Ras protein signal transduction [GO:0007265]; regulation of mitotic cell cycle [GO:0007346]; substrate-dependent cell migration, cell extension [GO:0006930]	adherens junction [GO:0005912]; azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; interleukin-5 receptor complex [GO:0005895]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	cell adhesion molecule binding [GO:0050839]; cytoskeletal anchor activity [GO:0008093]; ephrin receptor binding [GO:0046875]; frizzled binding [GO:0005109]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-5 receptor binding [GO:0005137]; ionotropic glutamate receptor binding [GO:0035255]; neurexin family protein binding [GO:0042043]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; syndecan binding [GO:0045545]	adherens junction [GO:0005912]; azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; interleukin-5 receptor complex [GO:0005895]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; cell adhesion molecule binding [GO:0050839]; cytoskeletal anchor activity [GO:0008093]; ephrin receptor binding [GO:0046875]; frizzled binding [GO:0005109]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-5 receptor binding [GO:0005137]; ionotropic glutamate receptor binding [GO:0035255]; neurexin family protein binding [GO:0042043]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; syndecan binding [GO:0045545]; actin cytoskeleton organization [GO:0030036]; chemical synaptic transmission [GO:0007268]; intracellular signal transduction [GO:0035556]; negative regulation of receptor internalization [GO:0002091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; presynapse assembly [GO:0099054]; protein targeting to membrane [GO:0006612]; proteolysis [GO:0006508]; Ras protein signal transduction [GO:0007265]; regulation of mitotic cell cycle [GO:0007346]; substrate-dependent cell migration, cell extension [GO:0006930]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:11179419}. Cell junction, adherens junction {ECO:0000269|PubMed:11179419}. Cell membrane {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:27386966}; Peripheral membrane protein {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:27386966}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}. Nucleus {ECO:0000269|PubMed:11179419}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Cytoplasm, cytosol {ECO:0000269|PubMed:11179419}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11179419}. Secreted, extracellular exosome {ECO:0000269|PubMed:22660413}. Membrane raft {ECO:0000269|PubMed:25893292}. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966). {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:27386966}.
O00562	reviewed	PITM1_HUMAN	Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)	PITPNM1 DRES9 NIR2 PITPNM	Homo sapiens (Human)	1244	FUNCTION: Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:22822086, PubMed:10531358). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}.		brain development [GO:0007420]; lipid metabolic process [GO:0006629]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipid transport [GO:0015914]; phototransduction [GO:0007602]; protein transport [GO:0015031]	cell body [GO:0044297]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496]	calcium ion binding [GO:0005509]; phosphatidic acid binding [GO:0070300]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; receptor tyrosine kinase binding [GO:0030971]	cell body [GO:0044297]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496]; calcium ion binding [GO:0005509]; phosphatidic acid binding [GO:0070300]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; receptor tyrosine kinase binding [GO:0030971]; brain development [GO:0007420]; lipid metabolic process [GO:0006629]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipid transport [GO:0015914]; phototransduction [GO:0007602]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12225667}; Peripheral membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12225667}; Peripheral membrane protein. Lipid droplet {ECO:0000269|PubMed:12225667}. Cleavage furrow {ECO:0000269|PubMed:15125835}. Midbody {ECO:0000269|PubMed:15125835}. Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets (PubMed:12225667). Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (PubMed:15125835). {ECO:0000269|PubMed:12225667, ECO:0000269|PubMed:15125835}.
O00566	reviewed	MPP10_HUMAN	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10)	MPHOSPH10 MPP10	Homo sapiens (Human)	681	FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}.		maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	chromosome [GO:0005694]; Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]	RNA binding [GO:0003723]	chromosome [GO:0005694]; Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; RNA binding [GO:0003723]; maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:9450966}. Chromosome {ECO:0000269|PubMed:9450966}. Note=Fibrillar region of the nucleolus (PubMed:9450966). After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase (PubMed:9450966). In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin (PubMed:9450966). The reassociation with nucleolus is preceeded by the arrival of fibrillarin (PubMed:9450966). {ECO:0000269|PubMed:9450966}.
O00567	reviewed	NOP56_HUMAN	Nucleolar protein 56 (Nucleolar protein 5A)	NOP56 NOL5A	Homo sapiens (Human)	594	FUNCTION: Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797}.		ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	box C/D RNP complex [GO:0031428]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pre-snoRNP complex [GO:0070761]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]	cadherin binding [GO:0045296]; histone methyltransferase binding [GO:1990226]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]	box C/D RNP complex [GO:0031428]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pre-snoRNP complex [GO:0070761]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; cadherin binding [GO:0045296]; histone methyltransferase binding [GO:1990226]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:9372940}. Cytoplasm {ECO:0000250|UniProtKB:Q9D6Z1}. Nucleus, nucleoplasm {ECO:0000305|PubMed:15574333}.
O00571	reviewed	DDX3X_HUMAN	ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)	DDX3X DBX DDX3	Homo sapiens (Human)	662	FUNCTION: Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:18628297, PubMed:17667941, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:31575075, PubMed:20127681, PubMed:21170385). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:21170385, PubMed:27980081, PubMed:19913487). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}.	MISCELLANEOUS: Encoded by an chromosome X-linked gene which may escape X chromosome inactivation in females. DDX3Y, its homolog on chromosome Y, is located on the Y non-recombinant portion. {ECO:0000269|PubMed:9381176}.	cell differentiation [GO:0030154]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to osmotic stress [GO:0071470]; cellular response to virus [GO:0098586]; chromosome segregation [GO:0007059]; cytosolic ribosome assembly [GO:0042256]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; gamete generation [GO:0007276]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway [GO:0097193]; lipid homeostasis [GO:0055088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of translation [GO:0017148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 8 signaling pathway [GO:0034161]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; positive regulation of translational initiation [GO:0045948]; positive regulation of type I interferon production [GO:0032481]; positive regulation of viral genome replication [GO:0045070]; primary miRNA processing [GO:0031053]; protein localization to cytoplasmic stress granule [GO:1903608]; response to virus [GO:0009615]; RNA secondary structure unwinding [GO:0010501]; stress granule assembly [GO:0034063]; translational initiation [GO:0006413]; Wnt signaling pathway [GO:0016055]	cell leading edge [GO:0031252]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lamellipodium [GO:0030027]; NLRP3 inflammasome complex [GO:0072559]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; CTPase activity [GO:0043273]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; eukaryotic initiation factor 4E binding [GO:0008190]; gamma-tubulin binding [GO:0043015]; GTPase activity [GO:0003924]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; primary miRNA binding [GO:0070878]; protein serine/threonine kinase activator activity [GO:0043539]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613]; RNA strand annealing activity [GO:0033592]; signaling adaptor activity [GO:0035591]; transcription factor binding [GO:0008134]; translation initiation factor binding [GO:0031369]	cell leading edge [GO:0031252]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lamellipodium [GO:0030027]; NLRP3 inflammasome complex [GO:0072559]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; CTPase activity [GO:0043273]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; eukaryotic initiation factor 4E binding [GO:0008190]; gamma-tubulin binding [GO:0043015]; GTPase activity [GO:0003924]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; primary miRNA binding [GO:0070878]; protein serine/threonine kinase activator activity [GO:0043539]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613]; RNA strand annealing activity [GO:0033592]; signaling adaptor activity [GO:0035591]; transcription factor binding [GO:0008134]; translation initiation factor binding [GO:0031369]; cell differentiation [GO:0030154]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to osmotic stress [GO:0071470]; cellular response to virus [GO:0098586]; chromosome segregation [GO:0007059]; cytosolic ribosome assembly [GO:0042256]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; gamete generation [GO:0007276]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway [GO:0097193]; lipid homeostasis [GO:0055088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of translation [GO:0017148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 8 signaling pathway [GO:0034161]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; positive regulation of translational initiation [GO:0045948]; positive regulation of type I interferon production [GO:0032481]; positive regulation of viral genome replication [GO:0045070]; primary miRNA processing [GO:0031053]; protein localization to cytoplasmic stress granule [GO:1903608]; response to virus [GO:0009615]; RNA secondary structure unwinding [GO:0010501]; stress granule assembly [GO:0034063]; translational initiation [GO:0006413]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:29899501}. Nucleus {ECO:0000269|PubMed:10329544, ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:22034099, ECO:0000269|PubMed:29899501, ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075}. Cytoplasm {ECO:0000269|PubMed:10329544, ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22034099, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:27105836, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075}. Cytoplasm, Stress granule {ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29062139}. Inflammasome {ECO:0000250|UniProtKB:Q62167}. Cell projection, lamellipodium {ECO:0000269|PubMed:28733330}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28842590}. Note=Shuttles between the nucleus and the cytosol (PubMed:15507209, PubMed:18636090, PubMed:29899501, PubMed:31575075, PubMed:30131165). Exported from the nucleus partly through the XPO1/CRM1 system and partly through NXF1/TAP (PubMed:15507209, PubMed:18636090, PubMed:18596238, PubMed:31575075, PubMed:30131165). Localizes to nuclear pores on the outer side of the nuclear membrane (PubMed:15507209). In the cytosol, partly colocalizes with mitochondria (PubMed:20127681). At G0, predominantly located in nucleus. In G1/S phase, predominantly cytoplasmic (PubMed:22034099). During prophase/prometaphase, localizes in close proximity to the condensing chromosomes (PubMed:30131165, PubMed:21730191). During telophase, localizes around the newly synthesized nuclear membrane and in the cytoplasm (PubMed:22034099). Colocalizes with TRPV4 at the plasma membrane. When TRPV4 channel is activated, intracellular Ca(2+) levels increase and the calmodulin/CAMKII pathway is activated, relocalizes to the nucleus (PubMed:29899501). WNT3A stimulation promotes DDX3 recruitment to the plasma membrane (PubMed:23413191). At the leading edge of migrating fibroblasts, colocalizes with CAPRIN1 and PABPC1 (PubMed:28733330). Localizes to centrosome throughout the cell cycle and associates with TP53 at centrosome during mitosis (PubMed:28842590). Translocates to the nucleus in response to HPIV-3 virus-mediated infection (PubMed:31575075). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:22034099, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29899501, ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075}.
O00574	reviewed	CXCR6_HUMAN	C-X-C chemokine receptor type 6 (CXC-R6) (CXCR-6) (CDw186) (G-protein coupled receptor STRL33) (G-protein coupled receptor bonzo) (CD antigen CD186)	CXCR6 BONZO STRL33 TYMSTR	Homo sapiens (Human)	342	FUNCTION: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.		calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; viral genome replication [GO:0019079]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine receptor activity [GO:0016494]; coreceptor activity [GO:0015026]; G protein-coupled receptor activity [GO:0004930]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine receptor activity [GO:0016494]; coreceptor activity [GO:0015026]; G protein-coupled receptor activity [GO:0004930]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; viral genome replication [GO:0019079]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O00584	reviewed	RNT2_HUMAN	Ribonuclease T2 (EC 4.6.1.19) (Ribonuclease 6)	RNASET2 RNASE6PL	Homo sapiens (Human)	256	FUNCTION: Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 (PubMed:31778653). Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides (PubMed:31778653). In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 (PubMed:31778653). Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria (PubMed:28730546, PubMed:30184494). Participates as well in degradation of mitochondrion-associated cytosolic rRNAs (PubMed:30385512). {ECO:0000269|PubMed:16620762, ECO:0000269|PubMed:19525954, ECO:0000269|PubMed:22735700, ECO:0000269|PubMed:28730546, ECO:0000269|PubMed:30184494, ECO:0000269|PubMed:30385512, ECO:0000269|PubMed:31778653}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	innate immune response [GO:0045087]; RNA catabolic process [GO:0006401]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; mitochondrial intermembrane space [GO:0005758]	ribonuclease T2 activity [GO:0033897]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA nuclease activity [GO:0004540]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; mitochondrial intermembrane space [GO:0005758]; ribonuclease T2 activity [GO:0033897]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA nuclease activity [GO:0004540]; innate immune response [GO:0045087]; RNA catabolic process [GO:0006401]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15809705, ECO:0000269|PubMed:16620762}. Lysosome lumen {ECO:0000269|PubMed:16620762}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:16620762}. Mitochondrion intermembrane space {ECO:0000269|PubMed:28730546, ECO:0000269|PubMed:30184494, ECO:0000269|PubMed:30385512}. Note=Full-length RNASET2 is found in the endoplasmic reticulum while smaller RNASET2 proteolytic products are found in the lysosome fraction. {ECO:0000269|PubMed:16620762}.
O00585	reviewed	CCL21_HUMAN	C-C motif chemokine 21 (6Ckine) (Beta-chemokine exodus-2) (Secondary lymphoid-tissue chemokine) (SLC) (Small-inducible cytokine A21)	CCL21 SCYA21 UNQ784/PRO1600	Homo sapiens (Human)	134	FUNCTION: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.		activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; cell maturation [GO:0048469]; cell-cell signaling [GO:0007267]; cellular response to chemokine [GO:1990869]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; chemokine-mediated signaling pathway [GO:0070098]; dendritic cell chemotaxis [GO:0002407]; dendritic cell dendrite assembly [GO:0097026]; establishment of T cell polarity [GO:0001768]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; immunological synapse formation [GO:0001771]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; mesangial cell-matrix adhesion [GO:0035759]; monocyte chemotaxis [GO:0002548]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of dendritic cell dendrite assembly [GO:2000548]; negative regulation of leukocyte tethering or rolling [GO:1903237]; neutrophil chemotaxis [GO:0030593]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell motility [GO:2000147]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of chemotaxis [GO:0050921]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of glycoprotein biosynthetic process [GO:0010560]; positive regulation of JNK cascade [GO:0046330]; positive regulation of myeloid dendritic cell chemotaxis [GO:2000529]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T cell migration [GO:2000406]; release of sequestered calcium ion into cytosol [GO:0051209]; response to prostaglandin E [GO:0034695]; ruffle organization [GO:0031529]; T cell costimulation [GO:0031295]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR7 chemokine receptor binding [GO:0031732]; chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR7 chemokine receptor binding [GO:0031732]; chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; cell maturation [GO:0048469]; cell-cell signaling [GO:0007267]; cellular response to chemokine [GO:1990869]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; chemokine-mediated signaling pathway [GO:0070098]; dendritic cell chemotaxis [GO:0002407]; dendritic cell dendrite assembly [GO:0097026]; establishment of T cell polarity [GO:0001768]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; immunological synapse formation [GO:0001771]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; mesangial cell-matrix adhesion [GO:0035759]; monocyte chemotaxis [GO:0002548]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of dendritic cell dendrite assembly [GO:2000548]; negative regulation of leukocyte tethering or rolling [GO:1903237]; neutrophil chemotaxis [GO:0030593]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell motility [GO:2000147]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of chemotaxis [GO:0050921]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of glycoprotein biosynthetic process [GO:0010560]; positive regulation of JNK cascade [GO:0046330]; positive regulation of myeloid dendritic cell chemotaxis [GO:2000529]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T cell migration [GO:2000406]; release of sequestered calcium ion into cytosol [GO:0051209]; response to prostaglandin E [GO:0034695]; ruffle organization [GO:0031529]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: Secreted.
O00587	reviewed	MFNG_HUMAN	Beta-1,3-N-acetylglucosaminyltransferase manic fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)	MFNG	Homo sapiens (Human)	321	FUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). {ECO:0000250|UniProtKB:O09008, ECO:0000269|PubMed:10935626}.		blastocyst formation [GO:0001825]; marginal zone B cell differentiation [GO:0002315]; pattern specification process [GO:0007389]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of Notch signaling pathway [GO:0008593]	extracellular space [GO:0005615]; Golgi membrane [GO:0000139]	metal ion binding [GO:0046872]; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity [GO:0033829]	extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; metal ion binding [GO:0046872]; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity [GO:0033829]; blastocyst formation [GO:0001825]; marginal zone B cell differentiation [GO:0002315]; pattern specification process [GO:0007389]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of Notch signaling pathway [GO:0008593]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
O00590	reviewed	ACKR2_HUMAN	Atypical chemokine receptor 2 (C-C chemokine receptor D6) (Chemokine receptor CCR-10) (Chemokine receptor CCR-9) (Chemokine-binding protein 2) (Chemokine-binding protein D6)	ACKR2 CCBP2 CCR10 CMKBR9 D6	Homo sapiens (Human)	384	FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs. {ECO:0000269|PubMed:23479571, ECO:0000269|PubMed:23633677}.		calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	actin filament [GO:0005884]; cytosol [GO:0005829]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; scavenger receptor activity [GO:0005044]	actin filament [GO:0005884]; cytosol [GO:0005829]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; scavenger receptor activity [GO:0005044]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
O00591	reviewed	GBRP_HUMAN	Gamma-aminobutyric acid receptor subunit pi (GABA(A) receptor subunit pi)	GABRP	Homo sapiens (Human)	440	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.		chloride transmembrane transport [GO:1902476]	chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594]	chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594]; chloride transmembrane transport [GO:1902476]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
O00592	reviewed	PODXL_HUMAN	Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)	PODXL PCLP PCLP1	Homo sapiens (Human)	558	FUNCTION: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}.		cell adhesion [GO:0007155]; cell migration [GO:0016477]; epithelial tube formation [GO:0072175]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-cell adhesion [GO:0022408]; podocyte development [GO:0072015]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; regulation of microvillus assembly [GO:0032534]	apical plasma membrane [GO:0016324]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane raft [GO:0045121]; microvillus membrane [GO:0031528]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; slit diaphragm [GO:0036057]		apical plasma membrane [GO:0016324]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane raft [GO:0045121]; microvillus membrane [GO:0031528]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; slit diaphragm [GO:0036057]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; epithelial tube formation [GO:0072175]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-cell adhesion [GO:0022408]; podocyte development [GO:0072015]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; regulation of microvillus assembly [GO:0032534]	SUBCELLULAR LOCATION: Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus {ECO:0000250}. Membrane raft {ECO:0000250}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with NHERF2 at the apical plasma membrane during epithelial polarization. Colocalizes with NHERF1 at the trans-Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with actin filaments, EZR and NHERF1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and NHERF2 at the apical cell membrane of glomerular epithelium cells (By similarity). Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial cells. Colocalizes with the submembrane actin of lamellipodia, particularly associated with ruffles. Colocalizes with vinculin at protrusions of cells. Colocalizes with ITGB1. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, RAB11A and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis (By similarity). {ECO:0000250}.
O00602	reviewed	FCN1_HUMAN	Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)	FCN1 FCNM	Homo sapiens (Human)	326	FUNCTION: Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. {ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:21037097}.		cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of opsonization [GO:1903028]; protein localization to cell surface [GO:0034394]; proteolysis [GO:0006508]; recognition of apoptotic cell [GO:0043654]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; serine-type endopeptidase complex [GO:1905370]	antigen binding [GO:0003823]; carbohydrate binding [GO:0030246]; carbohydrate derivative binding [GO:0097367]; G protein-coupled receptor binding [GO:0001664]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; serine-type endopeptidase complex [GO:1905370]; antigen binding [GO:0003823]; carbohydrate binding [GO:0030246]; carbohydrate derivative binding [GO:0097367]; G protein-coupled receptor binding [GO:0001664]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of opsonization [GO:1903028]; protein localization to cell surface [GO:0034394]; proteolysis [GO:0006508]; recognition of apoptotic cell [GO:0043654]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}. Cell membrane {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}; Peripheral membrane protein {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}; Extracellular side {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}. Note=Found on the monocyte and granulocyte surface (PubMed:20400674).
O00622	reviewed	CCN1_HUMAN	CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1)	CCN1 CYR61 GIG1 IGFBP10	Homo sapiens (Human)	381	FUNCTION: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.		apoptotic process involved in heart morphogenesis [GO:0003278]; atrial septum morphogenesis [GO:0060413]; atrioventricular valve morphogenesis [GO:0003181]; chemotaxis [GO:0006935]; chondroblast differentiation [GO:0060591]; chorio-allantoic fusion [GO:0060710]; extracellular matrix organization [GO:0030198]; intussusceptive angiogenesis [GO:0002041]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of apoptotic process [GO:0043066]; osteoblast differentiation [GO:0001649]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; reactive oxygen species metabolic process [GO:0072593]; regulation of ERK1 and ERK2 cascade [GO:0070372]; signal transduction [GO:0007165]; ventricular septum development [GO:0003281]; wound healing, spreading of cells [GO:0044319]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]	extracellular matrix binding [GO:0050840]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; integrin binding [GO:0005178]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular matrix binding [GO:0050840]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; apoptotic process involved in heart morphogenesis [GO:0003278]; atrial septum morphogenesis [GO:0060413]; atrioventricular valve morphogenesis [GO:0003181]; chemotaxis [GO:0006935]; chondroblast differentiation [GO:0060591]; chorio-allantoic fusion [GO:0060710]; extracellular matrix organization [GO:0030198]; intussusceptive angiogenesis [GO:0002041]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of apoptotic process [GO:0043066]; osteoblast differentiation [GO:0001649]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; reactive oxygen species metabolic process [GO:0072593]; regulation of ERK1 and ERK2 cascade [GO:0070372]; signal transduction [GO:0007165]; ventricular septum development [GO:0003281]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: Secreted.
O00623	reviewed	PEX12_HUMAN	Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor 3) (PAF-3)	PEX12 PAF3	Homo sapiens (Human)	359	FUNCTION: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:9354782, PubMed:9632816, PubMed:24662292). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (PubMed:24662292). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity). {ECO:0000250|UniProtKB:Q04370, ECO:0000269|PubMed:24662292, ECO:0000269|PubMed:9354782, ECO:0000269|PubMed:9632816}.		cellular response to reactive oxygen species [GO:0034614]; peroxisome organization [GO:0007031]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein targeting to peroxisome [GO:0006625]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	protein transmembrane transporter activity [GO:0008320]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein transmembrane transporter activity [GO:0008320]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; cellular response to reactive oxygen species [GO:0034614]; peroxisome organization [GO:0007031]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein targeting to peroxisome [GO:0006625]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:9922452}; Multi-pass membrane protein {ECO:0000255}.
O00624	reviewed	NPT3_HUMAN	Sodium-dependent phosphate transport protein 3 (Na(+)/PI cotransporter 3) (Sodium/phosphate cotransporter 3) (Solute carrier family 17 member 2)	SLC17A2 NPT3	Homo sapiens (Human)	439	FUNCTION: Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions (By similarity). Mediates chloride-dependent transport of urate (By similarity). Can actively transport inorganic phosphate into cells via Na(+) cotransport (By similarity). {ECO:0000250|UniProtKB:Q5SZA1}.		monoatomic anion transport [GO:0006820]; phosphate-containing compound metabolic process [GO:0006796]; sodium ion transport [GO:0006814]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]	sodium:phosphate symporter activity [GO:0005436]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sodium:phosphate symporter activity [GO:0005436]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143]; monoatomic anion transport [GO:0006820]; phosphate-containing compound metabolic process [GO:0006796]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q5SZA1}; Multi-pass membrane protein {ECO:0000255}.
O00625	reviewed	PIR_HUMAN	Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)	PIR	Homo sapiens (Human)	290	FUNCTION: Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). {ECO:0000269|PubMed:15951572, ECO:0000269|PubMed:17288615, ECO:0000269|PubMed:20010624, ECO:0000269|PubMed:20711196, ECO:0000269|PubMed:23716661}.		digestion [GO:0007586]; monocyte differentiation [GO:0030224]; transcription by RNA polymerase II [GO:0006366]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; quercetin 2,3-dioxygenase activity [GO:0008127]; transcription coregulator activity [GO:0003712]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; quercetin 2,3-dioxygenase activity [GO:0008127]; transcription coregulator activity [GO:0003712]; digestion [GO:0007586]; monocyte differentiation [GO:0030224]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20089166, ECO:0000269|PubMed:9079676}. Cytoplasm {ECO:0000269|PubMed:20089166}. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. {ECO:0000269|PubMed:20089166, ECO:0000269|PubMed:9079676}.
O00626	reviewed	CCL22_HUMAN	C-C motif chemokine 22 (CC chemokine STCP-1) (MDC(1-69)) (Macrophage-derived chemokine) (Small-inducible cytokine A22) (Stimulated T-cell chemotactic protein 1) [Cleaved into: MDC(3-69); MDC(5-69); MDC(7-69)]	CCL22 MDC SCYA22 A-152E5.1	Homo sapiens (Human)	93	FUNCTION: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.		cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; response to virus [GO:0009615]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; response to virus [GO:0009615]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
O00628	reviewed	PEX7_HUMAN	Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7)	PEX7 PTS2R	Homo sapiens (Human)	323	FUNCTION: Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal (PubMed:9090381, PubMed:11931631, PubMed:22057399, PubMed:25538232). Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol (PubMed:11931631, PubMed:22057399, PubMed:25538232). Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex (PubMed:11546814, PubMed:25538232). {ECO:0000269|PubMed:11546814, ECO:0000269|PubMed:11931631, ECO:0000269|PubMed:22057399, ECO:0000269|PubMed:25538232, ECO:0000269|PubMed:9090381}.		endochondral ossification [GO:0001958]; ether lipid biosynthetic process [GO:0008611]; fatty acid beta-oxidation [GO:0006635]; neuron migration [GO:0001764]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	enzyme binding [GO:0019899]; peroxisome matrix targeting signal-2 binding [GO:0005053]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; enzyme binding [GO:0019899]; peroxisome matrix targeting signal-2 binding [GO:0005053]; protein homodimerization activity [GO:0042803]; endochondral ossification [GO:0001958]; ether lipid biosynthetic process [GO:0008611]; fatty acid beta-oxidation [GO:0006635]; neuron migration [GO:0001764]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11931631, ECO:0000269|PubMed:25538232}. Peroxisome matrix {ECO:0000269|PubMed:11546814, ECO:0000269|PubMed:11931631, ECO:0000269|PubMed:25538232}. Note=Translocated into the peroxisome matrix together with PTS2-containing cargo proteins and PEX5. {ECO:0000269|PubMed:25538232}.
O00629	reviewed	IMA3_HUMAN	Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)	KPNA4 QIP1	Homo sapiens (Human)	521	FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.		dopamine secretion [GO:0014046]; gene expression [GO:0010467]; NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606]	cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]	cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; dopamine secretion [GO:0014046]; gene expression [GO:0010467]; NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
O00631	reviewed	SARCO_HUMAN	Sarcolipin	SLN	Homo sapiens (Human)	31	FUNCTION: Reversibly inhibits the activity of ATP2A1 and ATP2A2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CQD6, ECO:0000269|PubMed:11781085, ECO:0000269|PubMed:9575189}.		calcium ion transport [GO:0006816]; negative regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901895]; negative regulation of calcium ion binding [GO:1901877]; negative regulation of calcium ion import [GO:0090281]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of catalytic activity [GO:0043086]; negative regulation of protein-containing complex disassembly [GO:0043242]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein depolymerization [GO:1901881]; regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901894]; regulation of calcium ion transport [GO:0051924]; regulation of relaxation of muscle [GO:1901077]; sarcoplasmic reticulum calcium ion transport [GO:0070296]	membrane [GO:0016020]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]	ATPase binding [GO:0051117]; enzyme inhibitor activity [GO:0004857]	membrane [GO:0016020]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; ATPase binding [GO:0051117]; enzyme inhibitor activity [GO:0004857]; calcium ion transport [GO:0006816]; negative regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901895]; negative regulation of calcium ion binding [GO:1901877]; negative regulation of calcium ion import [GO:0090281]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of catalytic activity [GO:0043086]; negative regulation of protein-containing complex disassembly [GO:0043242]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein depolymerization [GO:1901881]; regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901894]; regulation of calcium ion transport [GO:0051924]; regulation of relaxation of muscle [GO:1901077]; sarcoplasmic reticulum calcium ion transport [GO:0070296]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:11781085, ECO:0000269|PubMed:9575189}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P42532}; Single-pass membrane protein {ECO:0000250}.
O00635	reviewed	TRI38_HUMAN	E3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet)	TRIM38 RNF15 RORET	Homo sapiens (Human)	465	FUNCTION: E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:23056470). Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity). Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (PubMed:24434549). {ECO:0000250|UniProtKB:Q5SZ99, ECO:0000269|PubMed:23056470, ECO:0000269|PubMed:24434549}.		innate immune response [GO:0045087]; negative regulation of defense response to virus [GO:0050687]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of viral entry into host cell [GO:0046598]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; regulation of interferon-beta production [GO:0032648]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; negative regulation of defense response to virus [GO:0050687]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of viral entry into host cell [GO:0046598]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; regulation of interferon-beta production [GO:0032648]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5SZ99}.
O00712	reviewed	NFIB_HUMAN	Nuclear factor 1 B-type (NF1-B) (Nuclear factor 1/B) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/B) (NF-I/B) (NFI-B) (TGGCA-binding protein)	NFIB	Homo sapiens (Human)	420	FUNCTION: Transcriptional activator of GFAP, essential for proper brain development (PubMed:30388402). Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. {ECO:0000269|PubMed:30388402}.		anterior commissure morphogenesis [GO:0021960]; brain development [GO:0007420]; cell differentiation involved in salivary gland development [GO:0060689]; cell proliferation in forebrain [GO:0021846]; chondrocyte differentiation [GO:0002062]; club cell differentiation [GO:0060486]; commissural neuron axon guidance [GO:0071679]; DNA replication [GO:0006260]; exit from mitosis [GO:0010458]; gene expression [GO:0010467]; glandular epithelial cell differentiation [GO:0002067]; glial cell differentiation [GO:0010001]; glial cell fate specification [GO:0021780]; glial cell proliferation [GO:0014009]; hindbrain development [GO:0030902]; lung ciliated cell differentiation [GO:0061141]; negative regulation of DNA binding [GO:0043392]; negative regulation of epithelial cell proliferation involved in lung morphogenesis [GO:2000795]; negative regulation of mesenchymal cell proliferation involved in lung development [GO:2000791]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; regeneration [GO:0031099]; regulation of transcription by RNA polymerase II [GO:0006357]; response to bacterium [GO:0009617]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; salivary gland cavitation [GO:0060662]; stem cell population maintenance [GO:0019827]; stem cell proliferation [GO:0072089]; tissue homeostasis [GO:0001894]; type I pneumocyte differentiation [GO:0060509]; type II pneumocyte differentiation [GO:0060510]	cerebellar mossy fiber [GO:0044300]; chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription regulator inhibitor activity [GO:0140416]	cerebellar mossy fiber [GO:0044300]; chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription regulator inhibitor activity [GO:0140416]; anterior commissure morphogenesis [GO:0021960]; brain development [GO:0007420]; cell differentiation involved in salivary gland development [GO:0060689]; cell proliferation in forebrain [GO:0021846]; chondrocyte differentiation [GO:0002062]; club cell differentiation [GO:0060486]; commissural neuron axon guidance [GO:0071679]; DNA replication [GO:0006260]; exit from mitosis [GO:0010458]; gene expression [GO:0010467]; glandular epithelial cell differentiation [GO:0002067]; glial cell differentiation [GO:0010001]; glial cell fate specification [GO:0021780]; glial cell proliferation [GO:0014009]; hindbrain development [GO:0030902]; lung ciliated cell differentiation [GO:0061141]; negative regulation of DNA binding [GO:0043392]; negative regulation of epithelial cell proliferation involved in lung morphogenesis [GO:2000795]; negative regulation of mesenchymal cell proliferation involved in lung development [GO:2000791]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; regeneration [GO:0031099]; regulation of transcription by RNA polymerase II [GO:0006357]; response to bacterium [GO:0009617]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; salivary gland cavitation [GO:0060662]; stem cell population maintenance [GO:0019827]; stem cell proliferation [GO:0072089]; tissue homeostasis [GO:0001894]; type I pneumocyte differentiation [GO:0060509]; type II pneumocyte differentiation [GO:0060510]	SUBCELLULAR LOCATION: Nucleus.
O00716	reviewed	E2F3_HUMAN	Transcription factor E2F3 (E2F-3)	E2F3 KIAA0075	Homo sapiens (Human)	465	FUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). {ECO:0000250|UniProtKB:O35261}.		G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of fat cell proliferation [GO:0070345]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; protein import into nucleus [GO:0006606]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation at RNA polymerase II promoter [GO:0006367]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of fat cell proliferation [GO:0070345]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; protein import into nucleus [GO:0006606]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus.
O00743	reviewed	PPP6_HUMAN	Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]	PPP6C PPP6	Homo sapiens (Human)	305	FUNCTION: Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956, PubMed:32474700). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (PubMed:29053956). Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32753499, PubMed:32474700). CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700). {ECO:0000269|PubMed:10227379, ECO:0000269|PubMed:17079228, ECO:0000269|PubMed:17568194, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:29053956, ECO:0000269|PubMed:32474700, ECO:0000269|PubMed:32753499}.		COPII vesicle coating [GO:0048208]; G1/S transition of mitotic cell cycle [GO:0000082]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; COPII vesicle coating [GO:0048208]; G1/S transition of mitotic cell cycle [GO:0000082]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:29053956}. Cytoplasm {ECO:0000269|PubMed:16769727, ECO:0000269|PubMed:17568194}.
O00744	reviewed	WN10B_HUMAN	Protein Wnt-10b (Protein Wnt-12)	WNT10B WNT12	Homo sapiens (Human)	389	FUNCTION: Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin. {ECO:0000305|PubMed:16477437, ECO:0000305|PubMed:21447090, ECO:0000305|PubMed:27321946}.		bone trabecula formation [GO:0060346]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to cAMP [GO:0071320]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; epithelial cell differentiation [GO:0030855]; fat cell differentiation [GO:0045444]; fungiform papilla development [GO:0061196]; G2/M transition of mitotic cell cycle [GO:0000086]; hematopoietic stem cell proliferation [GO:0071425]; lipid metabolic process [GO:0006629]; myoblast development [GO:0048627]; myoblast differentiation involved in skeletal muscle regeneration [GO:0014835]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of timing of anagen [GO:0051885]; protein stabilization [GO:0050821]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of skeletal muscle tissue development [GO:0048641]; sensory perception of taste [GO:0050909]; skeletal muscle fiber development [GO:0048741]; smoothened signaling pathway [GO:0007224]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; bone trabecula formation [GO:0060346]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to cAMP [GO:0071320]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; epithelial cell differentiation [GO:0030855]; fat cell differentiation [GO:0045444]; fungiform papilla development [GO:0061196]; G2/M transition of mitotic cell cycle [GO:0000086]; hematopoietic stem cell proliferation [GO:0071425]; lipid metabolic process [GO:0006629]; myoblast development [GO:0048627]; myoblast differentiation involved in skeletal muscle regeneration [GO:0014835]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of timing of anagen [GO:0051885]; protein stabilization [GO:0050821]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of skeletal muscle tissue development [GO:0048641]; sensory perception of taste [GO:0050909]; skeletal muscle fiber development [GO:0048741]; smoothened signaling pathway [GO:0007224]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
O00746	reviewed	NDKM_HUMAN	Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4)	NME4 NM23D	Homo sapiens (Human)	187	FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663). {ECO:0000269|PubMed:10799505, ECO:0000269|PubMed:17028143, ECO:0000269|PubMed:18635542, ECO:0000269|PubMed:23150663, ECO:0000305, ECO:0000305|PubMed:24970086}.		CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; lipid transport [GO:0006869]; nucleoside metabolic process [GO:0009116]; phosphorylation [GO:0016310]; UTP biosynthetic process [GO:0006228]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; cardiolipin binding [GO:1901612]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; cardiolipin binding [GO:1901612]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; lipid transport [GO:0006869]; nucleoside metabolic process [GO:0009116]; phosphorylation [GO:0016310]; UTP biosynthetic process [GO:0006228]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:18635542}; Peripheral membrane protein. Mitochondrion matrix {ECO:0000305|PubMed:18635542}. Note=Predominantly localized in the mitochondrion intermembrane space (PubMed:18635542). Colocalizes with OPA1 in mitochondria (PubMed:24970086). {ECO:0000269|PubMed:18635542, ECO:0000269|PubMed:24970086}.
O00748	reviewed	EST2_HUMAN	Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56)	CES2 ICE	Homo sapiens (Human)	559	FUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984). {ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:9169443, ECO:0000303|PubMed:28677105}.	MISCELLANEOUS: [Isoform 3]: Probably produced by alternative initiation of isoform 1. Does not contain a signal peptide. The biological function of the extra amino acids in the N-terminus remains to be determined. {ECO:0000303|PubMed:28677105}.; MISCELLANEOUS: [Isoform 4]: Probably produced by alternative initiation of isoform 2. Does not contain a signal peptide. The biological function of the extra amino acids in the N-terminus remains to be determined. {ECO:0000303|PubMed:28677105}.	catabolic process [GO:0009056]; prostaglandin metabolic process [GO:0006693]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]	carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; catabolic process [GO:0009056]; prostaglandin metabolic process [GO:0006693]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:22446793}.
O00750	reviewed	P3C2B_HUMAN	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta)	PIK3C2B	Homo sapiens (Human)	1634	FUNCTION: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:9830063, PubMed:11533253). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). {ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11533253, ECO:0000269|PubMed:9830063}.		autophagosome organization [GO:1905037]; cellular response to starvation [GO:0009267]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; autophagosome organization [GO:1905037]; cellular response to starvation [GO:0009267]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Microsome {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:9830063}. Cell membrane {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:9830063}. Cytoplasm, cytosol {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:9830063}. Nucleus {ECO:0000269|PubMed:14563213}. Endoplasmic reticulum {ECO:0000269|PubMed:14563213}. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.
O00754	reviewed	MA2B1_HUMAN	Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide]	MAN2B1 LAMAN MANB	Homo sapiens (Human)	1011	FUNCTION: Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages.		learning or memory [GO:0007611]; mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313]; protein deglycosylation [GO:0006517]; protein modification process [GO:0036211]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]	alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; learning or memory [GO:0007611]; mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313]; protein deglycosylation [GO:0006517]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Lysosome.
O00755	reviewed	WNT7A_HUMAN	Protein Wnt-7a	WNT7A	Homo sapiens (Human)	349	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity). {ECO:0000250|UniProtKB:P24383, ECO:0000269|PubMed:16826533, ECO:0000269|PubMed:30026314}.		angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; asymmetric protein localization involved in cell fate determination [GO:0045167]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cartilage condensation [GO:0001502]; cell fate commitment [GO:0045165]; cell proliferation in forebrain [GO:0021846]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system vasculogenesis [GO:0022009]; cerebellar granule cell differentiation [GO:0021707]; chondrocyte differentiation [GO:0002062]; dendritic spine morphogenesis [GO:0060997]; dorsal/ventral pattern formation [GO:0009953]; embryonic axis specification [GO:0000578]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; establishment of blood-brain barrier [GO:0060856]; establishment of cell polarity [GO:0030010]; excitatory synapse assembly [GO:1904861]; lens fiber cell development [GO:0070307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neurogenesis [GO:0050768]; neuron differentiation [GO:0030182]; neurotransmitter secretion [GO:0007269]; oviduct development [GO:0060066]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of excitatory synapse assembly [GO:1904891]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein localization to presynapse [GO:1905386]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of synapse assembly [GO:0051965]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynapse assembly [GO:0099068]; presynapse assembly [GO:0099054]; regulation of axon diameter [GO:0031133]; regulation of postsynapse organization [GO:0099175]; regulation of presynapse assembly [GO:1905606]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; secondary palate development [GO:0062009]; sex differentiation [GO:0007548]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; stem cell development [GO:0048864]; synaptic vesicle recycling [GO:0036465]; uterus morphogenesis [GO:0061038]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing, spreading of epidermal cells [GO:0035313]	cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; asymmetric protein localization involved in cell fate determination [GO:0045167]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cartilage condensation [GO:0001502]; cell fate commitment [GO:0045165]; cell proliferation in forebrain [GO:0021846]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system vasculogenesis [GO:0022009]; cerebellar granule cell differentiation [GO:0021707]; chondrocyte differentiation [GO:0002062]; dendritic spine morphogenesis [GO:0060997]; dorsal/ventral pattern formation [GO:0009953]; embryonic axis specification [GO:0000578]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; establishment of blood-brain barrier [GO:0060856]; establishment of cell polarity [GO:0030010]; excitatory synapse assembly [GO:1904861]; lens fiber cell development [GO:0070307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neurogenesis [GO:0050768]; neuron differentiation [GO:0030182]; neurotransmitter secretion [GO:0007269]; oviduct development [GO:0060066]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of excitatory synapse assembly [GO:1904891]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein localization to presynapse [GO:1905386]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of synapse assembly [GO:0051965]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynapse assembly [GO:0099068]; presynapse assembly [GO:0099054]; regulation of axon diameter [GO:0031133]; regulation of postsynapse organization [GO:0099175]; regulation of presynapse assembly [GO:1905606]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; secondary palate development [GO:0062009]; sex differentiation [GO:0007548]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; stem cell development [GO:0048864]; synaptic vesicle recycling [GO:0036465]; uterus morphogenesis [GO:0061038]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
O00757	reviewed	F16P2_HUMAN	Fructose-1,6-bisphosphatase isozyme 2 (FBPase 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2) (Muscle FBPase)	FBP2	Homo sapiens (Human)	339	FUNCTION: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. {ECO:0000269|PubMed:17350621, ECO:0000269|PubMed:18214967, ECO:0000269|PubMed:33977262}.	MISCELLANEOUS: Specific for the alpha-anomer of the substrate (PubMed:22120740). The Arg-33 mutant form has been shown to act on the beta-anomer (PubMed:24086250). {ECO:0000305|PubMed:22120740, ECO:0000305|PubMed:24086250}.	fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; sucrose biosynthetic process [GO:0005986]	anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Z disc [GO:0030018]	fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Z disc [GO:0030018]; fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; sucrose biosynthetic process [GO:0005986]	SUBCELLULAR LOCATION: Cell junction {ECO:0000250}. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration. {ECO:0000250}.
O00762	reviewed	UBE2C_HUMAN	Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)	UBE2C UBCH10	Homo sapiens (Human)	179	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. {ECO:0000269|PubMed:15558010, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27259151}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; exit from mitosis [GO:0010458]; free ubiquitin chain polymerization [GO:0010994]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ubiquitin-dependent protein catabolic process [GO:0006511]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-protein transferase activity [GO:0004842]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-protein transferase activity [GO:0004842]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; exit from mitosis [GO:0010458]; free ubiquitin chain polymerization [GO:0010994]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ubiquitin-dependent protein catabolic process [GO:0006511]	
O00763	reviewed	ACACB_HUMAN	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta)	ACACB ACC2 ACCB	Homo sapiens (Human)	2458	FUNCTION: Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:19900410, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). {ECO:0000250|UniProtKB:E9Q4Z2, ECO:0000269|PubMed:16854592, ECO:0000269|PubMed:19236960, ECO:0000269|PubMed:19900410, ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:26976583}.		acetyl-CoA metabolic process [GO:0006084]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of gene expression [GO:0010629]; positive regulation of heart growth [GO:0060421]; positive regulation of lipid storage [GO:0010884]; protein homotetramerization [GO:0051289]; regulation of glucose metabolic process [GO:0010906]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; biotin binding [GO:0009374]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; biotin binding [GO:0009374]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; acetyl-CoA metabolic process [GO:0006084]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of gene expression [GO:0010629]; positive regulation of heart growth [GO:0060421]; positive regulation of lipid storage [GO:0010884]; protein homotetramerization [GO:0051289]; regulation of glucose metabolic process [GO:0010906]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10677481}.
O00764	reviewed	PDXK_HUMAN	Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase)	PDXK C21orf124 C21orf97 PKH PNK PRED79	Homo sapiens (Human)	312	FUNCTION: Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (PubMed:9099727, PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503) (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions. {ECO:0000269|PubMed:10987144, ECO:0000269|PubMed:17766369, ECO:0000269|PubMed:19351586, ECO:0000269|PubMed:31187503, ECO:0000269|PubMed:9099727, ECO:0000305}.		phosphorylation [GO:0016310]; pyridoxal 5'-phosphate salvage [GO:0009443]; pyridoxal metabolic process [GO:0042817]; pyridoxamine metabolic process [GO:0042818]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]	ATP binding [GO:0005524]; lithium ion binding [GO:0031403]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; protein homodimerization activity [GO:0042803]; pyridoxal kinase activity [GO:0008478]; pyridoxal phosphate binding [GO:0030170]; sodium ion binding [GO:0031402]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; ATP binding [GO:0005524]; lithium ion binding [GO:0031403]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; protein homodimerization activity [GO:0042803]; pyridoxal kinase activity [GO:0008478]; pyridoxal phosphate binding [GO:0030170]; sodium ion binding [GO:0031402]; zinc ion binding [GO:0008270]; phosphorylation [GO:0016310]; pyridoxal 5'-phosphate salvage [GO:0009443]; pyridoxal metabolic process [GO:0042817]; pyridoxamine metabolic process [GO:0042818]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:9099727}.
O00767	reviewed	SCD_HUMAN	Stearoyl-CoA desaturase (hSCD1) (EC 1.14.19.1) (Acyl-CoA desaturase) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase)	SCD FADS5 SCD1 SCDOS	Homo sapiens (Human)	359	FUNCTION: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). {ECO:0000250|UniProtKB:P13516, ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:18765284}.		monounsaturated fatty acid biosynthetic process [GO:1903966]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to fatty acid [GO:0070542]; unsaturated fatty acid biosynthetic process [GO:0006636]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleolus [GO:0005730]	iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; palmitoyl-CoA 9-desaturase activity [GO:0032896]; stearoyl-CoA 9-desaturase activity [GO:0004768]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleolus [GO:0005730]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; palmitoyl-CoA 9-desaturase activity [GO:0032896]; stearoyl-CoA 9-desaturase activity [GO:0004768]; monounsaturated fatty acid biosynthetic process [GO:1903966]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to fatty acid [GO:0070542]; unsaturated fatty acid biosynthetic process [GO:0006636]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15907797}; Multi-pass membrane protein {ECO:0000269|PubMed:18765284, ECO:0000305}.
O14490	reviewed	DLGP1_HUMAN	Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)	DLGAP1 DAP1 GKAP	Homo sapiens (Human)	977	FUNCTION: Part of the postsynaptic scaffold in neuronal cells.		chemical synaptic transmission [GO:0007268]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572]	molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; chemical synaptic transmission [GO:0007268]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}.
O14492	reviewed	SH2B2_HUMAN	SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)	SH2B2 APS	Homo sapiens (Human)	632	FUNCTION: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}.		actin cytoskeleton organization [GO:0030036]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell receptor signaling pathway [GO:0050853]; B-1 B cell homeostasis [GO:0001922]; brown fat cell differentiation [GO:0050873]; cytokine-mediated signaling pathway [GO:0019221]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; regulation of metabolic process [GO:0019222]; regulation of Ras protein signal transduction [GO:0046578]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; stress fiber [GO:0001725]	identical protein binding [GO:0042802]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; stress fiber [GO:0001725]; identical protein binding [GO:0042802]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; actin cytoskeleton organization [GO:0030036]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell receptor signaling pathway [GO:0050853]; B-1 B cell homeostasis [GO:0001922]; brown fat cell differentiation [GO:0050873]; cytokine-mediated signaling pathway [GO:0019221]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; regulation of metabolic process [GO:0019222]; regulation of Ras protein signal transduction [GO:0046578]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9989826}. Cell membrane {ECO:0000269|PubMed:9989826}. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.
O14493	reviewed	CLD4_HUMAN	Claudin-4 (Clostridium perfringens enterotoxin receptor) (CPE-R) (CPE-receptor) (Williams-Beuren syndrome chromosomal region 8 protein)	CLDN4 CPER CPETR1 WBSCR8	Homo sapiens (Human)	209	FUNCTION: Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250|UniProtKB:O35054}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; circadian rhythm [GO:0007623]; establishment of skin barrier [GO:0061436]; female pregnancy [GO:0007565]; positive regulation of cell migration [GO:0030335]; positive regulation of metallopeptidase activity [GO:1905050]; positive regulation of wound healing [GO:0090303]; regulation of cell morphogenesis [GO:0022604]; renal absorption [GO:0070293]; response to progesterone [GO:0032570]	apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; basal plasma membrane [GO:0009925]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; chloride channel complex [GO:0034707]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; tight junction [GO:0070160]	chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; transmembrane signaling receptor activity [GO:0004888]	apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; basal plasma membrane [GO:0009925]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; chloride channel complex [GO:0034707]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; tight junction [GO:0070160]; chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; transmembrane signaling receptor activity [GO:0004888]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; circadian rhythm [GO:0007623]; establishment of skin barrier [GO:0061436]; female pregnancy [GO:0007565]; positive regulation of cell migration [GO:0030335]; positive regulation of metallopeptidase activity [GO:1905050]; positive regulation of wound healing [GO:0090303]; regulation of cell morphogenesis [GO:0022604]; renal absorption [GO:0070293]; response to progesterone [GO:0032570]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:O35054}. Cell membrane {ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}. Note=CLDN4 is required for tight junction localization in the kidney. {ECO:0000250|UniProtKB:O35054}.
O14494	reviewed	PLPP1_HUMAN	Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a)	PLPP1 LPP1 PPAP2A	Homo sapiens (Human)	284	FUNCTION: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9305923, PubMed:9705349, PubMed:9607309, PubMed:10962286, PubMed:17379599). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:12909631, PubMed:15461590). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:O08564, ECO:0000269|PubMed:10962286, ECO:0000269|PubMed:12909631, ECO:0000269|PubMed:15461590, ECO:0000269|PubMed:17379599, ECO:0000269|PubMed:9305923, ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349}.		androgen receptor signaling pathway [GO:0030521]; ceramide metabolic process [GO:0006672]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; negative regulation of cell population proliferation [GO:0008285]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of lipid metabolic process [GO:0019216]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148]; sphingosine metabolic process [GO:0006670]	apical plasma membrane [GO:0016324]; caveola [GO:0005901]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	ceramide-1-phosphate phosphatase activity [GO:0106235]; diacylglycerol diphosphate phosphatase activity [GO:0000810]; lipid phosphatase activity [GO:0042577]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392]	apical plasma membrane [GO:0016324]; caveola [GO:0005901]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; ceramide-1-phosphate phosphatase activity [GO:0106235]; diacylglycerol diphosphate phosphatase activity [GO:0000810]; lipid phosphatase activity [GO:0042577]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392]; androgen receptor signaling pathway [GO:0030521]; ceramide metabolic process [GO:0006672]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; negative regulation of cell population proliferation [GO:0008285]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of lipid metabolic process [GO:0019216]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148]; sphingosine metabolic process [GO:0006670]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10962286, ECO:0000269|PubMed:9705349}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:14527693}; Multi-pass membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:17005594}; Multi-pass membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:Q61469}; Multi-pass membrane protein {ECO:0000255}.
O14495	reviewed	PLPP3_HUMAN	Phospholipid phosphatase 3 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP)	PLPP3 LPP3 PPAP2B	Homo sapiens (Human)	311	FUNCTION: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9705349, PubMed:9607309, PubMed:27694435). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:9607309, PubMed:23591818, PubMed:27694435). Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (PubMed:27694435). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (PubMed:23591818). {ECO:0000250|UniProtKB:Q99JY8, ECO:0000269|PubMed:23591818, ECO:0000269|PubMed:27694435, ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349}.; FUNCTION: Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth (PubMed:20123964, PubMed:21569306). Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis (PubMed:12660161, PubMed:16099422). {ECO:0000269|PubMed:12660161, ECO:0000269|PubMed:16099422, ECO:0000269|PubMed:20123964, ECO:0000269|PubMed:21569306}.		Bergmann glial cell differentiation [GO:0060020]; blood vessel development [GO:0001568]; cell-cell adhesion mediated by integrin [GO:0033631]; ceramide metabolic process [GO:0006672]; gastrulation with mouth forming second [GO:0001702]; homotypic cell-cell adhesion [GO:0034109]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of protein phosphorylation [GO:0001933]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein stabilization [GO:0050821]; regulation of sphingolipid mediated signaling pathway [GO:1902068]; regulation of Wnt signaling pathway [GO:0030111]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148]; sphingosine metabolic process [GO:0006670]; wound healing [GO:0042060]	adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	ceramide-1-phosphate phosphatase activity [GO:0106235]; integrin binding [GO:0005178]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392]	adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; ceramide-1-phosphate phosphatase activity [GO:0106235]; integrin binding [GO:0005178]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392]; Bergmann glial cell differentiation [GO:0060020]; blood vessel development [GO:0001568]; cell-cell adhesion mediated by integrin [GO:0033631]; ceramide metabolic process [GO:0006672]; gastrulation with mouth forming second [GO:0001702]; homotypic cell-cell adhesion [GO:0034109]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of protein phosphorylation [GO:0001933]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein stabilization [GO:0050821]; regulation of sphingolipid mediated signaling pathway [GO:1902068]; regulation of Wnt signaling pathway [GO:0030111]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148]; sphingosine metabolic process [GO:0006670]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12660161, ECO:0000269|PubMed:20123964, ECO:0000269|PubMed:9705349}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Basolateral cell membrane {ECO:0000269|PubMed:14527693}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23591818}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:23591818}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Golgi apparatus membrane {ECO:0000269|PubMed:23591818}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:23591818}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Membrane raft {ECO:0000269|PubMed:17005594}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Note=Cycles between the endoplasmic reticulum and the Golgi. {ECO:0000269|PubMed:23591818}.
O14497	reviewed	ARI1A_HUMAN	AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD)	ARID1A BAF250 BAF250A C1orf4 OSA1 SMARCF1	Homo sapiens (Human)	2285	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.		androgen receptor signaling pathway [GO:0030521]; chromatin remodeling [GO:0006338]; glucocorticoid receptor signaling pathway [GO:0042921]; intracellular estrogen receptor signaling pathway [GO:0030520]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]	DNA binding [GO:0003677]; nuclear receptor binding [GO:0016922]; transcription coactivator activity [GO:0003713]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]; DNA binding [GO:0003677]; nuclear receptor binding [GO:0016922]; transcription coactivator activity [GO:0003713]; androgen receptor signaling pathway [GO:0030521]; chromatin remodeling [GO:0006338]; glucocorticoid receptor signaling pathway [GO:0042921]; intracellular estrogen receptor signaling pathway [GO:0030520]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:11318604, ECO:0000269|PubMed:26614907}.
O14503	reviewed	BHE40_HUMAN	Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein)	BHLHE40 BHLHB2 DEC1 SHARP2 STRA13	Homo sapiens (Human)	412	FUNCTION: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:12397359, PubMed:18411297). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (PubMed:15193144). Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:15560782). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706). Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558). May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (PubMed:19786558). Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (PubMed:28797635). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868). {ECO:0000269|PubMed:12397359, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:15193144, ECO:0000269|PubMed:15560782, ECO:0000269|PubMed:18411297, ECO:0000269|PubMed:19786558, ECO:0000269|PubMed:28797635, ECO:0000269|PubMed:30012868}.		anterior/posterior pattern specification [GO:0009952]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleus [GO:0005634]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; MRF binding [GO:0043426]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleus [GO:0005634]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; MRF binding [GO:0043426]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21829689}. Nucleus {ECO:0000269|PubMed:11278694, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:28797635}. Note=Predominantly localized in the nucleus (PubMed:11278694). {ECO:0000269|PubMed:11278694}.
O14508	reviewed	SOCS2_HUMAN	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)	SOCS2 CIS2 SSI2 STATI2	Homo sapiens (Human)	198	FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.		cellular response to hormone stimulus [GO:0032870]; growth hormone receptor signaling pathway [GO:0060396]; intracellular signal transduction [GO:0035556]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of apoptotic process [GO:0043066]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of neuron differentiation [GO:0045666]; protein ubiquitination [GO:0016567]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966]; response to estradiol [GO:0032355]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; growth hormone receptor binding [GO:0005131]; insulin-like growth factor receptor binding [GO:0005159]; JAK pathway signal transduction adaptor activity [GO:0008269]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; growth hormone receptor binding [GO:0005131]; insulin-like growth factor receptor binding [GO:0005159]; JAK pathway signal transduction adaptor activity [GO:0008269]; cellular response to hormone stimulus [GO:0032870]; growth hormone receptor signaling pathway [GO:0060396]; intracellular signal transduction [GO:0035556]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of apoptotic process [GO:0043066]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of neuron differentiation [GO:0045666]; protein ubiquitination [GO:0016567]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966]; response to estradiol [GO:0032355]	
O14511	reviewed	NRG2_HUMAN	Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)]	NRG2 NTAK	Homo sapiens (Human)	850	FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	animal organ development [GO:0048513]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102]; animal organ development [GO:0048513]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Pro-neuregulin-2, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; SUBCELLULAR LOCATION: [Neuregulin-2]: Secreted {ECO:0000250}.
O14512	reviewed	SOCS7_HUMAN	Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)	SOCS7 NAP4 SOCS6	Homo sapiens (Human)	581	FUNCTION: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250, ECO:0000269|PubMed:15677474, ECO:0000269|PubMed:16127460}.		intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; SH3 domain binding [GO:0017124]	cytosol [GO:0005829]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; SH3 domain binding [GO:0017124]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
O14514	reviewed	AGRB1_HUMAN	Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-40 (Vstat40); Vasculostatin-120 (Vstat120)]	ADGRB1 BAI1	Homo sapiens (Human)	1584	FUNCTION: Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720). {ECO:0000250|UniProtKB:C0HL12, ECO:0000250|UniProtKB:Q3UHD1, ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:23782696, ECO:0000269|PubMed:24509909, ECO:0000269|PubMed:26838550}.; FUNCTION: [Vasculostatin-120]: Inhibits angiogenesis in a CD36-dependent manner. {ECO:0000269|PubMed:15782143, ECO:0000269|PubMed:19176395}.; FUNCTION: [Vasculostatin-40]: Inhibits angiogenesis. {ECO:0000269|PubMed:22330140}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic cell clearance [GO:0043277]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; defense response to Gram-negative bacterium [GO:0050829]; engulfment of apoptotic cell [GO:0043652]; G protein-coupled receptor signaling pathway [GO:0007186]; innate immune response [GO:0045087]; muscle organ development [GO:0007517]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; peripheral nervous system development [GO:0007422]; phagocytosis, recognition [GO:0006910]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of synapse assembly [GO:0051965]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165]	cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	G protein-coupled receptor activity [GO:0004930]; lipopolysaccharide binding [GO:0001530]; PDZ domain binding [GO:0030165]; phosphatidylserine binding [GO:0001786]	cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; G protein-coupled receptor activity [GO:0004930]; lipopolysaccharide binding [GO:0001530]; PDZ domain binding [GO:0030165]; phosphatidylserine binding [GO:0001786]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic cell clearance [GO:0043277]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; defense response to Gram-negative bacterium [GO:0050829]; engulfment of apoptotic cell [GO:0043652]; G protein-coupled receptor signaling pathway [GO:0007186]; innate immune response [GO:0045087]; muscle organ development [GO:0007517]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; peripheral nervous system development [GO:0007422]; phagocytosis, recognition [GO:0006910]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of synapse assembly [GO:0051965]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12074842, ECO:0000269|PubMed:26838550}; Multi-pass membrane protein {ECO:0000255}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q3UHD1}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q3UHD1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:C0HL12}. Postsynaptic density {ECO:0000250|UniProtKB:Q3UHD1}.; SUBCELLULAR LOCATION: [Vasculostatin-120]: Secreted {ECO:0000269|PubMed:15782143, ECO:0000269|PubMed:22330140}.; SUBCELLULAR LOCATION: [Vasculostatin-40]: Secreted {ECO:0000269|PubMed:22330140}.
O14519	reviewed	CDKA1_HUMAN	Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor)	CDK2AP1 CDKAP1 DOC1	Homo sapiens (Human)	115	FUNCTION: Inhibitor of cyclin-dependent kinase CDK2 (By similarity). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:20523938, PubMed:16428440, PubMed:28977666). {ECO:0000250|UniProtKB:O35207, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666}.		cell cycle [GO:0007049]; DNA-templated DNA replication [GO:0006261]; positive regulation of protein phosphorylation [GO:0001934]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; perinuclear region of cytoplasm [GO:0048471]	DNA polymerase binding [GO:0070182]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; perinuclear region of cytoplasm [GO:0048471]; DNA polymerase binding [GO:0070182]; cell cycle [GO:0007049]; DNA-templated DNA replication [GO:0006261]; positive regulation of protein phosphorylation [GO:0001934]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Chromosome {ECO:0000269|PubMed:20523938}.
O14520	reviewed	AQP7_HUMAN	Aquaporin-7 (AQP-7) (Aquaglyceroporin-7) (Aquaporin adipose) (AQPap) (Aquaporin-7-like)	AQP7 AQP7L AQP9	Homo sapiens (Human)	342	FUNCTION: Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity). {ECO:0000250|UniProtKB:O54794, ECO:0000269|PubMed:11952783, ECO:0000269|PubMed:30420639, ECO:0000269|PubMed:30423801, ECO:0000269|PubMed:9405233}.		glycerol transmembrane transport [GO:0015793]; water transport [GO:0006833]	basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]	glycerol channel activity [GO:0015254]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250]	basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]; glycerol channel activity [GO:0015254]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250]; glycerol transmembrane transport [GO:0015793]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11952783, ECO:0000269|PubMed:28042826, ECO:0000269|PubMed:30423801, ECO:0000269|PubMed:9405233}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:O54794}. Cytoplasmic vesicle membrane {ECO:0000305|PubMed:27832861}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Lipid droplet {ECO:0000305|PubMed:27832861}. Note=Internalized from the cell membrane in response to catecholamine-induced activation of PKA; detected on intracellular membranes and colocalizes with lipid droplets (By similarity). Colocalizes with PLIN1 in adipocytes, probably on lipid droplets (PubMed:27832861). {ECO:0000250|UniProtKB:O54794, ECO:0000269|PubMed:27832861}.
O14521	reviewed	DHSD_HUMAN	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS) (CII-4) (QPs3) (Succinate dehydrogenase complex subunit D) (Succinate-ubiquinone oxidoreductase cytochrome b small subunit) (Succinate-ubiquinone reductase membrane anchor subunit)	SDHD SDH4	Homo sapiens (Human)	159	FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). {ECO:0000250}.		cellular response to hypoxia [GO:0071456]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; regulation of catecholamine secretion [GO:0050433]; tricarboxylic acid cycle [GO:0006099]	mitochondrial envelope [GO:0005740]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [GO:0005749]; mitochondrion [GO:0005739]	electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; succinate dehydrogenase (ubiquinone) activity [GO:0008177]; ubiquinone binding [GO:0048039]	mitochondrial envelope [GO:0005740]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [GO:0005749]; mitochondrion [GO:0005739]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; succinate dehydrogenase (ubiquinone) activity [GO:0008177]; ubiquinone binding [GO:0048039]; cellular response to hypoxia [GO:0071456]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; regulation of catecholamine secretion [GO:0050433]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
O14522	reviewed	PTPRT_HUMAN	Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho)	PTPRT KIAA0283	Homo sapiens (Human)	1441	FUNCTION: May be involved in both signal transduction and cellular adhesion in the CNS.		cell adhesion [GO:0007155]; cellular response to interleukin-6 [GO:0071354]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; protein dephosphorylation [GO:0006470]; regulation of synapse organization [GO:0050807]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	alpha-actinin binding [GO:0051393]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine phosphatase activity [GO:0004725]; STAT family protein binding [GO:0097677]; thiolester hydrolase activity [GO:0016790]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; alpha-actinin binding [GO:0051393]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine phosphatase activity [GO:0004725]; STAT family protein binding [GO:0097677]; thiolester hydrolase activity [GO:0016790]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; cell adhesion [GO:0007155]; cellular response to interleukin-6 [GO:0071354]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; protein dephosphorylation [GO:0006470]; regulation of synapse organization [GO:0050807]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
O14523	reviewed	C2C2L_HUMAN	Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24)	C2CD2L KIAA0285 TMEM24 DLNB23	Homo sapiens (Human)	706	FUNCTION: Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}.		positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; plasma membrane [GO:0005886]	insulin binding [GO:0043559]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]	cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; plasma membrane [GO:0005886]; insulin binding [GO:0043559]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28209843}; Single-pass membrane protein {ECO:0000269|PubMed:28209843}. Cell membrane {ECO:0000269|PubMed:28209843}; Peripheral membrane protein {ECO:0000269|PubMed:28209843}. Note=Localizes to sites of contact between the endoplasmic reticulum and the cell membrane (PubMed:28209843). Embedded into the endoplasmic reticulum membrane via its N-terminal transmembrane domain and associates with cell membrane via its C-terminus (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane and localizes to the reticular endoplasmic reticulum (PubMed:28209843). Reassociates with cell membrane upon dephosphorylation (PubMed:28209843). {ECO:0000269|PubMed:28209843}.
O14524	reviewed	NEMP1_HUMAN	Nuclear envelope integral membrane protein 1	NEMP1 KIAA0286 TMEM194 TMEM194A	Homo sapiens (Human)	444	FUNCTION: Together with EMD, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). Required for female fertility (By similarity). {ECO:0000250|UniProtKB:Q6ZQE4, ECO:0000269|PubMed:32923640}.		nuclear membrane organization [GO:0071763]	nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]		nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane organization [GO:0071763]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:Q6ZQE4}; Multi-pass membrane protein {ECO:0000255}; Nucleoplasmic side {ECO:0000250|UniProtKB:B9X187}. Nucleus envelope {ECO:0000250|UniProtKB:Q6ZQE4}. Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope. {ECO:0000250|UniProtKB:Q6ZQE4}.
O14525	reviewed	ASTN1_HUMAN	Astrotactin-1	ASTN1 ASTN KIAA0289	Homo sapiens (Human)	1302	FUNCTION: Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development. {ECO:0000250|UniProtKB:Q61137}.		locomotory behavior [GO:0007626]; neuron cell-cell adhesion [GO:0007158]; neuron migration [GO:0001764]	clathrin-coated vesicle [GO:0030136]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; perikaryon [GO:0043204]		clathrin-coated vesicle [GO:0030136]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; perikaryon [GO:0043204]; locomotory behavior [GO:0007626]; neuron cell-cell adhesion [GO:0007158]; neuron migration [GO:0001764]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q61137}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q61137}. Perikaryon {ECO:0000250|UniProtKB:Q61137}. Endosome {ECO:0000250|UniProtKB:Q61137}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q61137}. Note=Detected close to the anterior pole and at the base of the leading process in migrating neurons. Is internalized from the membrane via clathrin-coated vesicles and endosomes, and recycled to the anterior pole of the migrating cell. {ECO:0000250|UniProtKB:Q61137}.
O14526	reviewed	FCHO1_HUMAN	F-BAR domain only protein 1	FCHO1 KIAA0290	Homo sapiens (Human)	889	FUNCTION: Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}.		clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; positive regulation of T cell activation [GO:0050870]; T cell receptor signaling pathway [GO:0050852]	clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	AP-2 adaptor complex binding [GO:0035612]	clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; AP-2 adaptor complex binding [GO:0035612]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; positive regulation of T cell activation [GO:0050870]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150, ECO:0000305|PubMed:32098969}; Peripheral membrane protein {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}; Cytoplasmic side {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes.
O14529	reviewed	CUX2_HUMAN	Homeobox protein cut-like 2 (Homeobox protein cux-2)	CUX2 CUTL2 KIAA0293	Homo sapiens (Human)	1486	FUNCTION: Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner. {ECO:0000250|UniProtKB:P70298}.		cellular response to organic substance [GO:0071310]; cognition [GO:0050890]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of synapse assembly [GO:0051965]; regulation of transcription by RNA polymerase II [GO:0006357]; short-term memory [GO:0007614]	chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to organic substance [GO:0071310]; cognition [GO:0050890]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of synapse assembly [GO:0051965]; regulation of transcription by RNA polymerase II [GO:0006357]; short-term memory [GO:0007614]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00374}.
O14530	reviewed	TXND9_HUMAN	Thioredoxin domain-containing protein 9 (ATP-binding protein associated with cell differentiation) (Protein 1-4)	TXNDC9 APACD	Homo sapiens (Human)	226	FUNCTION: Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin. {ECO:0000269|PubMed:16415341}.		microtubule cytoskeleton organization [GO:0000226]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634]	cadherin binding [GO:0045296]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; microtubule cytoskeleton organization [GO:0000226]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9CQ79}. Nucleus {ECO:0000250|UniProtKB:Q9CQ79}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9CQ79}. Midbody {ECO:0000250|UniProtKB:Q9CQ79}. Note=Co-localizes with beta-tubulin in the centrosome. {ECO:0000250|UniProtKB:Q9CQ79}.
O14531	reviewed	DPYL4_HUMAN	Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4)	DPYSL4 CRMP3 ULIP4	Homo sapiens (Human)	572	FUNCTION: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}.		nervous system development [GO:0007399]	cytosol [GO:0005829]	filamin binding [GO:0031005]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]	cytosol [GO:0005829]; filamin binding [GO:0031005]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O14543	reviewed	SOCS3_HUMAN	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)	SOCS3 CIS3 SSI3	Homo sapiens (Human)	225	FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820). {ECO:0000250|UniProtKB:O35718, ECO:0000269|PubMed:15601820}.		branching involved in labyrinthine layer morphogenesis [GO:0060670]; cellular response to interleukin-17 [GO:0097398]; cellular response to leukemia inhibitory factor [GO:1990830]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; placenta blood vessel development [GO:0060674]; positive regulation of cell differentiation [GO:0045597]; protein ubiquitination [GO:0016567]; T-helper 17 cell lineage commitment [GO:0072540]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; miRNA binding [GO:0035198]; phosphotyrosine residue binding [GO:0001784]; protein kinase inhibitor activity [GO:0004860]; protein tyrosine kinase inhibitor activity [GO:0030292]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; miRNA binding [GO:0035198]; phosphotyrosine residue binding [GO:0001784]; protein kinase inhibitor activity [GO:0004860]; protein tyrosine kinase inhibitor activity [GO:0030292]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cellular response to interleukin-17 [GO:0097398]; cellular response to leukemia inhibitory factor [GO:1990830]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; placenta blood vessel development [GO:0060674]; positive regulation of cell differentiation [GO:0045597]; protein ubiquitination [GO:0016567]; T-helper 17 cell lineage commitment [GO:0072540]	
O14544	reviewed	SOCS6_HUMAN	Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)	SOCS6 CIS4 SOCS4	Homo sapiens (Human)	535	FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}.		defense response [GO:0006952]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; negative regulation of T cell activation [GO:0050868]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of growth [GO:0040008]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; phosphatidylinositol 3-kinase complex [GO:0005942]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; phosphatidylinositol 3-kinase complex [GO:0005942]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; defense response [GO:0006952]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; negative regulation of T cell activation [GO:0050868]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of growth [GO:0040008]	
O14556	reviewed	G3PT_HUMAN	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (EC 1.2.1.12) (Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2) (GAPDH-2) (Spermatogenic glyceraldehyde-3-phosphate dehydrogenase)	GAPDHS GAPD2 GAPDH2 GAPDS HSD-35 HSD35	Homo sapiens (Human)	408	FUNCTION: May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity). {ECO:0000250}.		flagellated sperm motility [GO:0030317]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; positive regulation of glycolytic process [GO:0045821]	cytosol [GO:0005829]; nucleus [GO:0005634]	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; NADP binding [GO:0050661]	cytosol [GO:0005829]; nucleus [GO:0005634]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; flagellated sperm motility [GO:0030317]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; positive regulation of glycolytic process [GO:0045821]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O14558	reviewed	HSPB6_HUMAN	Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20)	HSPB6	Homo sapiens (Human)	160	FUNCTION: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. {ECO:0000269|PubMed:14717697, ECO:0000269|PubMed:19845507, ECO:0000269|PubMed:20843828, ECO:0000269|PubMed:22427880, ECO:0000305, ECO:0000305|PubMed:22794279}.		chaperone-mediated protein folding [GO:0061077]; negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; protein refolding [GO:0042026]; response to heat [GO:0009408]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	protein folding chaperone [GO:0044183]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; structural constituent of eye lens [GO:0005212]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; protein folding chaperone [GO:0044183]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; structural constituent of eye lens [GO:0005212]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]; negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; protein refolding [GO:0042026]; response to heat [GO:0009408]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus {ECO:0000269|PubMed:19464326}. Secreted {ECO:0000269|PubMed:22427880}. Note=Translocates to nuclear foci during heat shock. {ECO:0000269|PubMed:19464326}.
O14559	reviewed	RHG33_HUMAN	Rho GTPase-activating protein 33 (Rho-type GTPase-activating protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein)	ARHGAP33 SNX26 TCGAP	Homo sapiens (Human)	1287	FUNCTION: May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity). {ECO:0000250}.		protein transport [GO:0015031]; regulation of dendritic spine morphogenesis [GO:0061001]; response to toxic substance [GO:0009636]; small GTPase mediated signal transduction [GO:0007264]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GTPase activator activity [GO:0005096]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; GTPase activator activity [GO:0005096]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]; protein transport [GO:0015031]; regulation of dendritic spine morphogenesis [GO:0061001]; response to toxic substance [GO:0009636]; small GTPase mediated signal transduction [GO:0007264]	
O14561	reviewed	ACPM_HUMAN	Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit)	NDUFAB1	Homo sapiens (Human)	156	FUNCTION: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) (PubMed:27626371). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:31664822). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). {ECO:0000250|UniProtKB:P52505, ECO:0000250|UniProtKB:Q9H1K1, ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:31664822}.	MISCELLANEOUS: In contrast to other accessory subunits of complex I, NDUFAB1 is the only subunit that is essential for cell viability in HEK293T cells. Since knockout cells lack assembled complex I and die in galactose media, this suggests that the essential role of NDUFAB1 is independent of complex I. {ECO:0000269|PubMed:27626371}.	[2Fe-2S] cluster assembly [GO:0044571]; aerobic respiration [GO:0009060]; fatty acid biosynthetic process [GO:0006633]; iron-sulfur cluster assembly [GO:0016226]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; protein lipoylation [GO:0009249]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	acyl binding [GO:0000035]; acyl carrier activity [GO:0000036]; calcium ion binding [GO:0005509]; fatty acid binding [GO:0005504]; mitochondrial large ribosomal subunit binding [GO:0140978]	iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; acyl binding [GO:0000035]; acyl carrier activity [GO:0000036]; calcium ion binding [GO:0005509]; fatty acid binding [GO:0005504]; mitochondrial large ribosomal subunit binding [GO:0140978]; [2Fe-2S] cluster assembly [GO:0044571]; aerobic respiration [GO:0009060]; fatty acid biosynthetic process [GO:0006633]; iron-sulfur cluster assembly [GO:0016226]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; protein lipoylation [GO:0009249]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12611891, ECO:0000269|PubMed:28892042}.
O14569	reviewed	C56D2_HUMAN	Transmembrane reductase CYB561D2 (EC 7.2.1.3) (Cytochrome b561 domain-containing protein 2) (Putative tumor suppressor protein 101F6)	CYB561D2 101F6 LUCA12.2	Homo sapiens (Human)	222	FUNCTION: Transmembrane reductase that may use ascorbate as an electron donor in the cytoplasm and transfer electrons across endoplasmic reticulum membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in the lumen of that compartment. {ECO:0000269|PubMed:23235316, ECO:0000269|PubMed:23641721}.		ascorbate homeostasis [GO:0140576]	cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; vesicle [GO:0031982]	heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; transmembrane ascorbate ferrireductase activity [GO:0140571]; transmembrane monodehydroascorbate reductase activity [GO:0140575]	cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; vesicle [GO:0031982]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; transmembrane ascorbate ferrireductase activity [GO:0140571]; transmembrane monodehydroascorbate reductase activity [GO:0140575]; ascorbate homeostasis [GO:0140576]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9WUE3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9WUE3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}.
O14576	reviewed	DC1I1_HUMAN	Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1)	DYNC1I1 DNCI1 DNCIC1	Homo sapiens (Human)	645	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.		transport along microtubule [GO:0010970]; vesicle transport along microtubule [GO:0047496]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule [GO:0005874]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; spindle pole [GO:0000922]; vesicle [GO:0031982]	cytoskeletal motor activity [GO:0003774]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; spectrin binding [GO:0030507]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule [GO:0005874]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; spindle pole [GO:0000922]; vesicle [GO:0031982]; cytoskeletal motor activity [GO:0003774]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; spectrin binding [GO:0030507]; transport along microtubule [GO:0010970]; vesicle transport along microtubule [GO:0047496]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19229290}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19229290}.
O14578	reviewed	CTRO_HUMAN	Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21)	CIT CRIK KIAA0949 STK21	Homo sapiens (Human)	2027	FUNCTION: Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}.		generation of neurons [GO:0048699]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; negative regulation of hippo signaling [GO:0035331]; neuron apoptotic process [GO:0051402]; phosphorylation [GO:0016310]; positive regulation of cytokinesis [GO:0032467]	cytosol [GO:0005829]; membrane [GO:0016020]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase inhibitor activity [GO:0030291]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; transcription coactivator binding [GO:0001223]	cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase inhibitor activity [GO:0030291]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; transcription coactivator binding [GO:0001223]; generation of neurons [GO:0048699]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; negative regulation of hippo signaling [GO:0035331]; neuron apoptotic process [GO:0051402]; phosphorylation [GO:0016310]; positive regulation of cytokinesis [GO:0032467]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O14579	reviewed	COPE_HUMAN	Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP)	COPE	Homo sapiens (Human)	308	FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein localization to axon [GO:0099612]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; transport vesicle [GO:0030133]	structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; transport vesicle [GO:0030133]; structural molecule activity [GO:0005198]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein localization to axon [GO:0099612]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
O14593	reviewed	RFXK_HUMAN	DNA-binding protein RFXANK (Ankyrin repeat family A protein 1) (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein)	RFXANK ANKRA1 RFXB	Homo sapiens (Human)	260	FUNCTION: Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:9806546, PubMed:10072068, PubMed:10725724). May also potentiate the activation of RAF1 (By similarity). {ECO:0000250|UniProtKB:Q9Z205, ECO:0000269|PubMed:10072068, ECO:0000269|PubMed:10725724, ECO:0000269|PubMed:9806546}.; FUNCTION: Isoform 2 is not involved in the positive regulation of MHC class II genes. {ECO:0000269|PubMed:10072068}.		positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Ras protein signal transduction [GO:0007265]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Ras protein signal transduction [GO:0007265]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z205}. Nucleus {ECO:0000250|UniProtKB:Q9Z205}.
O14594	reviewed	NCAN_HUMAN	Neurocan core protein (Chondroitin sulfate proteoglycan 3)	NCAN CSPG3 NEUR	Homo sapiens (Human)	1321	FUNCTION: May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.		cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; perineuronal net [GO:0072534]; synapse [GO:0045202]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; perineuronal net [GO:0072534]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25326458}.
O14595	reviewed	CTDS2_HUMAN	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 2) (NLI-interacting factor 2) (Protein OS-4) (Small C-terminal domain phosphatase 2) (Small CTD phosphatase 2) (SCP2)	CTDSP2 NIF2 OS4 SCP2	Homo sapiens (Human)	271	FUNCTION: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}.		negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of protein phosphorylation [GO:0001933]; protein dephosphorylation [GO:0006470]	nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of protein phosphorylation [GO:0001933]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
O14607	reviewed	UTY_HUMAN	Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY)	UTY KDM6C	Homo sapiens (Human)	1347	FUNCTION: Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. {ECO:0000269|PubMed:24798337}.		regulation of gene expression [GO:0010468]	MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]	chromatin DNA binding [GO:0031490]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; chromatin DNA binding [GO:0031490]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O14610	reviewed	GBGT2_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 (G gamma-C) (G-gamma-8) (G-gamma-9) (Guanine nucleotide binding protein gamma transducing activity polypeptide 2)	GNGT2 GNG8 GNG9 GNGT8	Homo sapiens (Human)	69	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.		G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]	heterotrimeric G-protein complex [GO:0005834]	G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]	heterotrimeric G-protein complex [GO:0005834]; G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
O14613	reviewed	BORG1_HUMAN	Cdc42 effector protein 2 (Binder of Rho GTPases 1)	CDC42EP2 BORG1 CEP2	Homo sapiens (Human)	210	FUNCTION: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}.		actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cellular response to type II interferon [GO:0071346]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; opioid peptide activity [GO:0001515]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; opioid peptide activity [GO:0001515]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cellular response to type II interferon [GO:0071346]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:11035016}; Peripheral membrane protein {ECO:0000269|PubMed:11035016}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11035016}.
O14617	reviewed	AP3D1_HUMAN	AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin)	AP3D1 PRO0039	Homo sapiens (Human)	1153	FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}.		anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; endosome to melanosome transport [GO:0035646]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; platelet dense granule organization [GO:0060155]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to membrane [GO:0072657]; protein targeting to vacuole [GO:0006623]; regulation of sequestering of zinc ion [GO:0061088]; synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle coating [GO:0016183]; synaptic vesicle membrane organization [GO:0048499]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]	AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; postsynapse [GO:0098794]; presynaptic endosome [GO:0098830]; terminal bouton [GO:0043195]		AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; postsynapse [GO:0098794]; presynaptic endosome [GO:0098830]; terminal bouton [GO:0043195]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; endosome to melanosome transport [GO:0035646]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; platelet dense granule organization [GO:0060155]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to membrane [GO:0072657]; protein targeting to vacuole [GO:0006623]; regulation of sequestering of zinc ion [GO:0061088]; synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle coating [GO:0016183]; synaptic vesicle membrane organization [GO:0048499]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
O14618	reviewed	CCS_HUMAN	Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone)	CCS	Homo sapiens (Human)	274	FUNCTION: Delivers copper to copper zinc superoxide dismutase (SOD1).		cellular response to oxidative stress [GO:0034599]; protein maturation by copper ion transfer [GO:0015680]; removal of superoxide radicals [GO:0019430]; superoxide metabolic process [GO:0006801]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; copper ion binding [GO:0005507]; protein-disulfide reductase activity [GO:0015035]; superoxide dismutase copper chaperone activity [GO:0016532]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; copper ion binding [GO:0005507]; protein-disulfide reductase activity [GO:0015035]; superoxide dismutase copper chaperone activity [GO:0016532]; cellular response to oxidative stress [GO:0034599]; protein maturation by copper ion transfer [GO:0015680]; removal of superoxide radicals [GO:0019430]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9726962}.
O14625	reviewed	CXL11_HUMAN	C-X-C motif chemokine 11 (Beta-R1) (H174) (Interferon gamma-inducible protein 9) (IP-9) (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Small-inducible cytokine B11)	CXCL11 ITAC SCYB11 SCYB9B	Homo sapiens (Human)	94	FUNCTION: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]; T cell chemotaxis [GO:0010818]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; heparin binding [GO:0008201]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; heparin binding [GO:0008201]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]; T cell chemotaxis [GO:0010818]	SUBCELLULAR LOCATION: Secreted.
O14627	reviewed	CDX4_HUMAN	Homeobox protein CDX-4 (Caudal-type homeobox protein 4)	CDX4	Homo sapiens (Human)	284			animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; blood vessel development [GO:0001568]; cell differentiation [GO:0030154]; labyrinthine layer development [GO:0060711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; blood vessel development [GO:0001568]; cell differentiation [GO:0030154]; labyrinthine layer development [GO:0060711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
O14628	reviewed	ZN195_HUMAN	Zinc finger protein 195	ZNF195 ZNFP104	Homo sapiens (Human)	629	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O14633	reviewed	LCE2B_HUMAN	Late cornified envelope protein 2B (Late envelope protein 10) (Skin-specific protein Xp5) (Small proline-rich-like epidermal differentiation complex protein 1B)	LCE2B LEP10 SPRL1B XP5	Homo sapiens (Human)	110	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	epidermis development [GO:0008544]; keratinization [GO:0031424]		identical protein binding [GO:0042802]	identical protein binding [GO:0042802]; epidermis development [GO:0008544]; keratinization [GO:0031424]	
O14638	reviewed	ENPP3_HUMAN	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (NPP3) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]	ENPP3 PDNP3	Homo sapiens (Human)	875	FUNCTION: Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has also alkaline phosphodiesterase activity (PubMed:11342463). {ECO:0000250|UniProtKB:Q6DYE8, ECO:0000269|PubMed:11342463, ECO:0000269|PubMed:29717535}.		ATP metabolic process [GO:0046034]; basophil activation involved in immune response [GO:0002276]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of mast cell proliferation [GO:0070667]; nucleoside triphosphate catabolic process [GO:0009143]; phosphate ion homeostasis [GO:0055062]; phosphate-containing compound metabolic process [GO:0006796]; pyrimidine nucleotide metabolic process [GO:0006220]	apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]	calcium ion binding [GO:0005509]; nucleic acid binding [GO:0003676]; nucleoside triphosphate diphosphatase activity [GO:0047429]; phosphodiesterase I activity [GO:0004528]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; nucleic acid binding [GO:0003676]; nucleoside triphosphate diphosphatase activity [GO:0047429]; phosphodiesterase I activity [GO:0004528]; zinc ion binding [GO:0008270]; ATP metabolic process [GO:0046034]; basophil activation involved in immune response [GO:0002276]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of mast cell proliferation [GO:0070667]; nucleoside triphosphate catabolic process [GO:0009143]; phosphate ion homeostasis [GO:0055062]; phosphate-containing compound metabolic process [GO:0006796]; pyrimidine nucleotide metabolic process [GO:0006220]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11342463}; Single-pass type II membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:15072822}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:15072822}. Note=Detected at the cell surface of basophils (PubMed:11342463). Detected at the apical plasma membrane of bile duct cells (PubMed:15072822). Located to the apical surface in intestinal and kidney epithelial cells. Secreted in serum, and in lumen of epithelial cells. {ECO:0000269|PubMed:11342463, ECO:0000269|PubMed:15072822}.
O14639	reviewed	ABLM1_HUMAN	Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin)	ABLIM1 ABLIM KIAA0059 LIMAB1	Homo sapiens (Human)	778	FUNCTION: May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}.		animal organ morphogenesis [GO:0009887]; cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; visual perception [GO:0007601]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; stress fiber [GO:0001725]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; metal ion binding [GO:0046872]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; stress fiber [GO:0001725]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; metal ion binding [GO:0046872]; animal organ morphogenesis [GO:0009887]; cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with the cytoskeleton. {ECO:0000250}.
O14640	reviewed	DVL1_HUMAN	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)	DVL1	Homo sapiens (Human)	695	FUNCTION: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).		axon extension [GO:0048675]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; collateral sprouting [GO:0048668]; convergent extension involved in neural plate elongation [GO:0022007]; cytoplasmic microtubule organization [GO:0031122]; dendrite morphogenesis [GO:0048813]; dendritic spine morphogenesis [GO:0060997]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; negative regulation of protein binding [GO:0032091]; negative regulation of protein kinase activity [GO:0006469]; neural tube development [GO:0021915]; neuromuscular junction development [GO:0007528]; neurotransmitter secretion [GO:0007269]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of neuron projection development [GO:0010976]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to presynapse [GO:1905386]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prepulse inhibition [GO:0060134]; presynapse assembly [GO:0099054]; protein localization to microtubule [GO:0035372]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of DNA-templated transcription [GO:0006355]; regulation of neurotransmitter levels [GO:0001505]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; regulation of synaptic vesicle exocytosis [GO:2000300]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; social behavior [GO:0035176]; synapse organization [GO:0050808]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; Wnt signalosome [GO:1990909]	beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]	clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; Wnt signalosome [GO:1990909]; beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]; axon extension [GO:0048675]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; collateral sprouting [GO:0048668]; convergent extension involved in neural plate elongation [GO:0022007]; cytoplasmic microtubule organization [GO:0031122]; dendrite morphogenesis [GO:0048813]; dendritic spine morphogenesis [GO:0060997]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; negative regulation of protein binding [GO:0032091]; negative regulation of protein kinase activity [GO:0006469]; neural tube development [GO:0021915]; neuromuscular junction development [GO:0007528]; neurotransmitter secretion [GO:0007269]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of neuron projection development [GO:0010976]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to presynapse [GO:1905386]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prepulse inhibition [GO:0060134]; presynapse assembly [GO:0099054]; protein localization to microtubule [GO:0035372]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of DNA-templated transcription [GO:0006355]; regulation of neurotransmitter levels [GO:0001505]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; regulation of synaptic vesicle exocytosis [GO:2000300]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; social behavior [GO:0035176]; synapse organization [GO:0050808]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members. {ECO:0000250}.
O14641	reviewed	DVL2_HUMAN	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)	DVL2	Homo sapiens (Human)	736	FUNCTION: Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499}.		canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340]; cochlea morphogenesis [GO:0090103]; convergent extension involved in neural plate elongation [GO:0022007]; heart development [GO:0007507]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; neural tube closure [GO:0001843]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of DNA-templated transcription [GO:0006355]; segment specification [GO:0007379]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	aggresome [GO:0016235]; apical part of cell [GO:0045177]; clathrin-coated endocytic vesicle [GO:0045334]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein self-association [GO:0043621]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]	aggresome [GO:0016235]; apical part of cell [GO:0045177]; clathrin-coated endocytic vesicle [GO:0045334]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein self-association [GO:0043621]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340]; cochlea morphogenesis [GO:0090103]; convergent extension involved in neural plate elongation [GO:0022007]; heart development [GO:0007507]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; neural tube closure [GO:0001843]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of DNA-templated transcription [GO:0006355]; segment specification [GO:0007379]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q60838}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q60838}; Cytoplasmic side {ECO:0000250|UniProtKB:Q60838}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q60838}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q60838}. Nucleus {ECO:0000269|PubMed:25805136}. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136). {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:25805136}.
O14645	reviewed	IDLC_HUMAN	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28)	DNALI1	Homo sapiens (Human)	258	FUNCTION: May play a dynamic role in flagellar motility.			9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293]; dynein complex [GO:0030286]; filopodium [GO:0030175]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]	dynein heavy chain binding [GO:0045504]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293]; dynein complex [GO:0030286]; filopodium [GO:0030175]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]; dynein heavy chain binding [GO:0045504]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:27120127}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:31178125}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q6GN86}. Cytoplasm {ECO:0000250|UniProtKB:Q8BVN8}.
O14646	reviewed	CHD1_HUMAN	Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1)	CHD1	Homo sapiens (Human)	1710	FUNCTION: ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}.		chromatin remodeling [GO:0006338]; nucleosome organization [GO:0034728]; positive regulation by host of viral transcription [GO:0043923]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; chromatin remodeling [GO:0006338]; nucleosome organization [GO:0034728]; positive regulation by host of viral transcription [GO:0043923]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40201}. Cytoplasm {ECO:0000250|UniProtKB:P40201}. Note=Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis. {ECO:0000250|UniProtKB:P40201}.
O14647	reviewed	CHD2_HUMAN	Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.12) (ATP-dependent helicase CHD2)	CHD2	Homo sapiens (Human)	1828	FUNCTION: DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}.		DNA damage response [GO:0006974]; gene expression [GO:0010467]; hematopoietic stem cell differentiation [GO:0060218]; muscle organ development [GO:0007517]; nucleosome organization [GO:0034728]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; DNA damage response [GO:0006974]; gene expression [GO:0010467]; hematopoietic stem cell differentiation [GO:0060218]; muscle organ development [GO:0007517]; nucleosome organization [GO:0034728]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Binds to myogenic gene promoters. {ECO:0000250}.
O14649	reviewed	KCNK3_HUMAN	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1)	KCNK3 TASK TASK1	Homo sapiens (Human)	394	FUNCTION: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. {ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:9312005}.	MISCELLANEOUS: Inhibited by external acidification. Activated by halothane and isoflurane.	cellular response to hypoxia [GO:0071456]; cellular response to zinc ion [GO:0071294]; chemical synaptic transmission [GO:0007268]; cochlea development [GO:0090102]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of resting membrane potential [GO:0060075]; response to xenobiotic stimulus [GO:0009410]; stabilization of membrane potential [GO:0030322]	plasma membrane [GO:0005886]; synapse [GO:0045202]	monoatomic ion channel activity [GO:0005216]; open rectifier potassium channel activity [GO:0005252]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; S100 protein binding [GO:0044548]	plasma membrane [GO:0005886]; synapse [GO:0045202]; monoatomic ion channel activity [GO:0005216]; open rectifier potassium channel activity [GO:0005252]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; S100 protein binding [GO:0044548]; cellular response to hypoxia [GO:0071456]; cellular response to zinc ion [GO:0071294]; chemical synaptic transmission [GO:0007268]; cochlea development [GO:0090102]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of resting membrane potential [GO:0060075]; response to xenobiotic stimulus [GO:0009410]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23169818}; Multi-pass membrane protein {ECO:0000305}.
O14653	reviewed	GOSR2_HUMAN	Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin)	GOSR2 GS27	Homo sapiens (Human)	212	FUNCTION: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. {ECO:0000269|PubMed:9349823}.		intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; vesicle fusion [GO:0006906]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; SNARE complex [GO:0031201]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; SNARE complex [GO:0031201]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:21549339}; Single-pass type IV membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:9349823}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O35165}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. {ECO:0000250|UniProtKB:O35165}.
O14654	reviewed	IRS4_HUMAN	Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)	IRS4	Homo sapiens (Human)	1257	FUNCTION: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}.		insulin receptor signaling pathway [GO:0008286]; signal transduction [GO:0007165]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	insulin receptor binding [GO:0005158]; phosphatidylinositol 3-kinase binding [GO:0043548]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; insulin receptor binding [GO:0005158]; phosphatidylinositol 3-kinase binding [GO:0043548]; insulin receptor signaling pathway [GO:0008286]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9553137}; Peripheral membrane protein {ECO:0000269|PubMed:9553137}; Cytoplasmic side {ECO:0000269|PubMed:9553137}.
O14656	reviewed	TOR1A_HUMAN	Torsin-1A (Dystonia 1 protein) (Torsin ATPase-1A) (EC 3.6.4.-) (Torsin family 1 member A)	TOR1A DQ2 DYT1 TA TORA	Homo sapiens (Human)	332	FUNCTION: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues. {ECO:0000269|PubMed:15505207, ECO:0000269|PubMed:16361107, ECO:0000269|PubMed:17428918, ECO:0000269|PubMed:18167355, ECO:0000269|PubMed:18827015, ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:20169475, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24930953}.		cell adhesion [GO:0007155]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein folding [GO:0061077]; ER-associated misfolded protein catabolic process [GO:0071712]; intermediate filament cytoskeleton organization [GO:0045104]; neuron projection development [GO:0031175]; nuclear envelope organization [GO:0006998]; nuclear membrane organization [GO:0071763]; organelle organization [GO:0006996]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; protein deneddylation [GO:0000338]; protein localization to nucleus [GO:0034504]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of protein localization to cell surface [GO:2000008]; response to oxidative stress [GO:0006979]; synaptic vesicle membrane organization [GO:0048499]; synaptic vesicle transport [GO:0048489]; wound healing, spreading of cells [GO:0044319]	cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; secretory granule [GO:0030141]; synaptic vesicle [GO:0008021]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; misfolded protein binding [GO:0051787]; unfolded protein binding [GO:0051082]	cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; secretory granule [GO:0030141]; synaptic vesicle [GO:0008021]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; misfolded protein binding [GO:0051787]; unfolded protein binding [GO:0051082]; cell adhesion [GO:0007155]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein folding [GO:0061077]; ER-associated misfolded protein catabolic process [GO:0071712]; intermediate filament cytoskeleton organization [GO:0045104]; neuron projection development [GO:0031175]; nuclear envelope organization [GO:0006998]; nuclear membrane organization [GO:0071763]; organelle organization [GO:0006996]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; protein deneddylation [GO:0000338]; protein localization to nucleus [GO:0034504]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of protein localization to cell surface [GO:2000008]; response to oxidative stress [GO:0006979]; synaptic vesicle membrane organization [GO:0048499]; synaptic vesicle transport [GO:0048489]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:29053766}. Nucleus membrane {ECO:0000269|PubMed:14970196, ECO:0000269|PubMed:29053766}; Peripheral membrane protein {ECO:0000305}. Cell projection, growth cone {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasm, cytoskeleton. Note=Upon oxidative stress, redistributes to protusions from the cell surface (By similarity). Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2. {ECO:0000250}.
O14657	reviewed	TOR1B_HUMAN	Torsin-1B (Torsin ATPase-1B) (EC 3.6.4.-) (Torsin family 1 member B)	TOR1B DQ1 FKSG18	Homo sapiens (Human)	336	FUNCTION: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues. {ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}.		chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum organization [GO:0007029]; nuclear membrane organization [GO:0071763]; protein localization to nucleus [GO:0034504]; response to unfolded protein [GO:0006986]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum organization [GO:0007029]; nuclear membrane organization [GO:0071763]; protein localization to nucleus [GO:0034504]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15147511}. Nucleus membrane {ECO:0000269|PubMed:15147511}.
O14662	reviewed	STX16_HUMAN	Syntaxin-16 (Syn16)	STX16	Homo sapiens (Human)	325	FUNCTION: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}.	MISCELLANEOUS: [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type IV membrane protein.; SUBCELLULAR LOCATION: [Isoform C]: Cytoplasm.
O14669	reviewed	TMG2_HUMAN	Transmembrane gamma-carboxyglutamic acid protein 2 (Proline-rich gamma-carboxyglutamic acid protein 2) (Proline-rich Gla protein 2)	PRRG2 PRGP2 TMG2	Homo sapiens (Human)	202				extracellular space [GO:0005615]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17502622}; Single-pass type I membrane protein {ECO:0000255}.
O14672	reviewed	ADA10_HUMAN	Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)	ADAM10 KUZ MADM	Homo sapiens (Human)	748	FUNCTION: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905, PubMed:29224781). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:24990881). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). {ECO:0000250|UniProtKB:O35598, ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905, ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:24990881, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:29224781}.; FUNCTION: (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. {ECO:0000269|PubMed:20624979, ECO:0000269|PubMed:30463011}.		adherens junction organization [GO:0034332]; amyloid precursor protein catabolic process [GO:0042987]; cell-cell signaling [GO:0007267]; cochlea development [GO:0090102]; constitutive protein ectodomain proteolysis [GO:0051089]; epidermal growth factor receptor ligand maturation [GO:0038004]; extracellular matrix disassembly [GO:0022617]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte activation [GO:0042117]; negative regulation of cell adhesion [GO:0007162]; negative regulation of gene expression [GO:0010629]; Notch signaling pathway [GO:0007219]; pore complex assembly [GO:0046931]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of T cell chemotaxis [GO:0010820]; postsynapse organization [GO:0099173]; protein catabolic process at postsynapse [GO:0140249]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Notch signaling pathway [GO:0008593]; regulation of postsynapse organization [GO:0099175]; regulation of vasculature development [GO:1901342]; response to tumor necrosis factor [GO:0034612]; toxin transport [GO:1901998]	adherens junction [GO:0005912]; axon [GO:0030424]; cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; postsynaptic density [GO:0014069]; specific granule membrane [GO:0035579]; synaptic membrane [GO:0097060]; tertiary granule membrane [GO:0070821]; tetraspanin-enriched microdomain [GO:0097197]	endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; signaling receptor binding [GO:0005102]	adherens junction [GO:0005912]; axon [GO:0030424]; cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; postsynaptic density [GO:0014069]; specific granule membrane [GO:0035579]; synaptic membrane [GO:0097060]; tertiary granule membrane [GO:0070821]; tetraspanin-enriched microdomain [GO:0097197]; endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; signaling receptor binding [GO:0005102]; adherens junction organization [GO:0034332]; amyloid precursor protein catabolic process [GO:0042987]; cell-cell signaling [GO:0007267]; cochlea development [GO:0090102]; constitutive protein ectodomain proteolysis [GO:0051089]; epidermal growth factor receptor ligand maturation [GO:0038004]; extracellular matrix disassembly [GO:0022617]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte activation [GO:0042117]; negative regulation of cell adhesion [GO:0007162]; negative regulation of gene expression [GO:0010629]; Notch signaling pathway [GO:0007219]; pore complex assembly [GO:0046931]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of T cell chemotaxis [GO:0010820]; postsynapse organization [GO:0099173]; protein catabolic process at postsynapse [GO:0140249]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Notch signaling pathway [GO:0008593]; regulation of postsynapse organization [GO:0099175]; regulation of vasculature development [GO:1901342]; response to tumor necrosis factor [GO:0034612]; toxin transport [GO:1901998]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20624979, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:24990881, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:29430990, ECO:0000269|PubMed:30463011}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:12475894}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:12475894}. Cell projection, axon {ECO:0000250|UniProtKB:O35598}. Cell projection, dendrite {ECO:0000250|UniProtKB:O35598}. Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Cytoplasm {ECO:0000269|PubMed:30463011}. Note=Is localized in the plasma membrane but is also expressed in the Golgi apparatus and in clathrin-coated vesicles derived likely from the Golgi (PubMed:12475894). During long term depression, it is recruited to the cell membrane by DLG1 (PubMed:23676497). The immature form is mainly located near cytoplasmic fibrillar structures, while the mature form is predominantly located at zonula adherens and the cell membrane (PubMed:30463011). The localization and clustering of mature ADAM10 to zonula adherens is regulated by AFDN, TSPAN33, PLEKHA7 and PDZD11 (PubMed:30463011). {ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:30463011}.
O14678	reviewed	ABCD4_HUMAN	Lysosomal cobalamin transporter ABCD4 (EC 7.6.2.8) (ATP-binding cassette sub-family D member 4) (PMP70-related protein) (P70R) (Peroxisomal membrane protein 1-like) (PXMP1-L) (Peroxisomal membrane protein 69) (PMP69)	ABCD4 PXMP1L	Homo sapiens (Human)	606	FUNCTION: Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner (PubMed:22922874, PubMed:33845046, PubMed:28572511, PubMed:31467407). Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane (PubMed:27456980). Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791). {ECO:0000269|PubMed:22922874, ECO:0000269|PubMed:27456980, ECO:0000269|PubMed:28572511, ECO:0000269|PubMed:31467407, ECO:0000269|PubMed:33845046, ECO:0000303|PubMed:25535791}.		cellular response to leukemia inhibitory factor [GO:1990830]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import into peroxisome [GO:0015910]; peroxisome organization [GO:0007031]; transmembrane transport [GO:0055085]; very long-chain fatty acid catabolic process [GO:0042760]	ATP-binding cassette (ABC) transporter complex [GO:0043190]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	ABC-type vitamin B12 transporter activity [GO:0015420]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; identical protein binding [GO:0042802]; long-chain fatty acid transporter activity [GO:0005324]	ATP-binding cassette (ABC) transporter complex [GO:0043190]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; ABC-type vitamin B12 transporter activity [GO:0015420]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; identical protein binding [GO:0042802]; long-chain fatty acid transporter activity [GO:0005324]; cellular response to leukemia inhibitory factor [GO:1990830]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import into peroxisome [GO:0015910]; peroxisome organization [GO:0007031]; transmembrane transport [GO:0055085]; very long-chain fatty acid catabolic process [GO:0042760]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27456980}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:22922874, ECO:0000269|PubMed:25535791, ECO:0000269|PubMed:27456980, ECO:0000269|PubMed:28572511, ECO:0000269|PubMed:33845046}; Multi-pass membrane protein {ECO:0000255}. Note=Targeted by LMBRD1 lysosomal chaperone to the lysosomal membrane. {ECO:0000269|PubMed:27456980, ECO:0000269|PubMed:28572511}.
O14681	reviewed	EI24_HUMAN	Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein)	EI24 PIG8	Homo sapiens (Human)	340	FUNCTION: Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). {ECO:0000250}.		apoptotic process [GO:0006915]; macroautophagy [GO:0016236]; negative regulation of cell growth [GO:0030308]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear membrane [GO:0031965]	importin-alpha family protein binding [GO:0061676]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; importin-alpha family protein binding [GO:0061676]; apoptotic process [GO:0006915]; macroautophagy [GO:0016236]; negative regulation of cell growth [GO:0030308]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:21154811}; Multi-pass membrane protein {ECO:0000269|PubMed:21154811}. Cytoplasm {ECO:0000269|PubMed:21154811}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
O14682	reviewed	ENC1_HUMAN	Ectoderm-neural cortex protein 1 (ENC-1) (Kelch-like protein 37) (Nuclear matrix protein NRP/B) (p53-induced gene 10 protein)	ENC1 KLHL37 NRPB PIG10	Homo sapiens (Human)	589	FUNCTION: Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism. {ECO:0000269|PubMed:19424503}.		negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; positive regulation of neuron projection development [GO:0010976]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; protein ubiquitination [GO:0016567]	chromatin [GO:0000785]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	actin binding [GO:0003779]	chromatin [GO:0000785]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; actin binding [GO:0003779]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; positive regulation of neuron projection development [GO:0010976]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:19424503}. Cytoplasm {ECO:0000269|PubMed:19424503}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19424503}.
O14684	reviewed	PTGES_HUMAN	Prostaglandin E synthase (EC 5.3.99.3) (Glutathione peroxidase PTGES) (EC 1.11.1.-) (Glutathione transferase PTGES) (EC 2.5.1.18) (Microsomal glutathione S-transferase 1-like 1) (MGST1-L1) (Microsomal prostaglandin E synthase 1) (MPGES-1) (p53-induced gene 12 protein)	PTGES MGST1L1 MPGES1 PGES PIG12	Homo sapiens (Human)	152	FUNCTION: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:18682561, PubMed:10377395, PubMed:12672824, PubMed:12460774, PubMed:10869354, PubMed:12244105). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824). {ECO:0000250|UniProtKB:Q9JM51, ECO:0000269|PubMed:10377395, ECO:0000269|PubMed:10869354, ECO:0000269|PubMed:12244105, ECO:0000269|PubMed:12460774, ECO:0000269|PubMed:12672824, ECO:0000269|PubMed:18682561}.		cell population proliferation [GO:0008283]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of prostaglandin secretion [GO:0032308]; prostaglandin biosynthetic process [GO:0001516]; prostaglandin metabolic process [GO:0006693]; regulation of fever generation [GO:0031620]; regulation of inflammatory response [GO:0050727]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope lumen [GO:0005641]; perinuclear region of cytoplasm [GO:0048471]	glutathione binding [GO:0043295]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; prostaglandin-D synthase activity [GO:0004667]; prostaglandin-E synthase activity [GO:0050220]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope lumen [GO:0005641]; perinuclear region of cytoplasm [GO:0048471]; glutathione binding [GO:0043295]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; prostaglandin-D synthase activity [GO:0004667]; prostaglandin-E synthase activity [GO:0050220]; cell population proliferation [GO:0008283]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of prostaglandin secretion [GO:0032308]; prostaglandin biosynthetic process [GO:0001516]; prostaglandin metabolic process [GO:0006693]; regulation of fever generation [GO:0031620]; regulation of inflammatory response [GO:0050727]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10377395, ECO:0000269|PubMed:16439136, ECO:0000269|PubMed:18682561, ECO:0000269|PubMed:27684486}; Multi-pass membrane protein {ECO:0000303|PubMed:18682561}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10869354}. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment. {ECO:0000269|PubMed:10869354}.
O14686	reviewed	KMT2D_HUMAN	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	KMT2D ALR MLL2 MLL4	Homo sapiens (Human)	5537	FUNCTION: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:17500065). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.	MISCELLANEOUS: This gene mapped to a chromosomal region involved in duplications and translocations associated with cancer.	beta-catenin-TCF complex assembly [GO:1904837]; heterochromatin formation [GO:0031507]; methylation [GO:0032259]; oocyte growth [GO:0001555]; oogenesis [GO:0048477]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; response to estrogen [GO:0043627]	MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]	MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; beta-catenin-TCF complex assembly [GO:1904837]; heterochromatin formation [GO:0031507]; methylation [GO:0032259]; oocyte growth [GO:0001555]; oogenesis [GO:0048477]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; response to estrogen [GO:0043627]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23508102}.
O14713	reviewed	ITBP1_HUMAN	Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1)	ITGB1BP1 ICAP1	Homo sapiens (Human)	200	FUNCTION: Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. {ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:11807099, ECO:0000269|PubMed:11919189, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:15703214, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20616313, ECO:0000269|PubMed:21768292, ECO:0000269|Ref.19}.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	activation of protein kinase B activity [GO:0032148]; biomineral tissue development [GO:0031214]; blood vessel diameter maintenance [GO:0097746]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; myoblast migration [GO:0051451]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of protein binding [GO:0032091]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; Notch signaling pathway [GO:0007219]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; receptor clustering [GO:0043113]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of GTPase activity [GO:0043087]; regulation of integrin-mediated signaling pathway [GO:2001044]; tube formation [GO:0035148]	cell periphery [GO:0071944]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GDP-dissociation inhibitor activity [GO:0005092]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]	cell periphery [GO:0071944]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; GDP-dissociation inhibitor activity [GO:0005092]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]; activation of protein kinase B activity [GO:0032148]; biomineral tissue development [GO:0031214]; blood vessel diameter maintenance [GO:0097746]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; myoblast migration [GO:0051451]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of protein binding [GO:0032091]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; Notch signaling pathway [GO:0007219]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; receptor clustering [GO:0043113]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of GTPase activity [GO:0043087]; regulation of integrin-mediated signaling pathway [GO:2001044]; tube formation [GO:0035148]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, lamellipodium. Cell projection, ruffle. Note=Nucleocytoplasmic shuttling protein; shuttles between nucleus and cytoplasm in a integrin-dependent manner; probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin; cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 integrin-rich peripheral ruffles and lamellipodia during initial cell spreading on fibronectin and/or collagen.
O14717	reviewed	TRDMT_HUMAN	tRNA (cytosine(38)-C(5))-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog HsaIIP) (DNA MTase homolog HsaIIP) (M.HsaIIP) (PuMet)	TRDMT1 DNMT2	Homo sapiens (Human)	391	FUNCTION: Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). {ECO:0000269|PubMed:16424344}.		response to amphetamine [GO:0001975]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA stabilization [GO:0036416]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]; tRNA (cytosine-5-)-methyltransferase activity [GO:0016428]; tRNA methyltransferase activity [GO:0008175]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; tRNA (cytosine-5-)-methyltransferase activity [GO:0016428]; tRNA methyltransferase activity [GO:0008175]; response to amphetamine [GO:0001975]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA stabilization [GO:0036416]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16424344}.
O14727	reviewed	APAF_HUMAN	Apoptotic protease-activating factor 1 (APAF-1)	APAF1 KIAA0413	Homo sapiens (Human)	1248	FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}.	MISCELLANEOUS: Physiological concentrations of calcium ions negatively affect the assembly of apoptosome by inhibiting nucleotide exchange in the monomeric form.	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cardiac muscle cell apoptotic process [GO:0010659]; cell differentiation [GO:0030154]; cellular response to transforming growth factor beta stimulus [GO:0071560]; forebrain development [GO:0030900]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; nervous system development [GO:0007399]; neural tube closure [GO:0001843]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; regulation of apoptotic DNA fragmentation [GO:1902510]; regulation of apoptotic process [GO:0042981]; response to G1 DNA damage checkpoint signaling [GO:0072432]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]	apoptosome [GO:0043293]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]	apoptosome [GO:0043293]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cardiac muscle cell apoptotic process [GO:0010659]; cell differentiation [GO:0030154]; cellular response to transforming growth factor beta stimulus [GO:0071560]; forebrain development [GO:0030900]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; nervous system development [GO:0007399]; neural tube closure [GO:0001843]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; regulation of apoptotic DNA fragmentation [GO:1902510]; regulation of apoptotic process [GO:0042981]; response to G1 DNA damage checkpoint signaling [GO:0072432]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12804598}.
O14730	reviewed	RIOK3_HUMAN	Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog)	RIOK3 SUDD	Homo sapiens (Human)	519	FUNCTION: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843). {ECO:0000269|PubMed:19557502, ECO:0000269|PubMed:22418843, ECO:0000269|PubMed:24807708, ECO:0000269|PubMed:25865883}.		cellular response to dsDNA [GO:1990786]; cellular response to dsRNA [GO:0071359]; cellular response to virus [GO:0098586]; chromosome segregation [GO:0007059]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; maturation of SSU-rRNA [GO:0030490]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of protein-containing complex assembly [GO:0031333]; phosphorylation [GO:0016310]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]	cytosol [GO:0005829]; preribosome, small subunit precursor [GO:0030688]	ATP binding [GO:0005524]; caspase binding [GO:0089720]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; preribosome, small subunit precursor [GO:0030688]; ATP binding [GO:0005524]; caspase binding [GO:0089720]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cellular response to dsDNA [GO:1990786]; cellular response to dsRNA [GO:0071359]; cellular response to virus [GO:0098586]; chromosome segregation [GO:0007059]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; maturation of SSU-rRNA [GO:0030490]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of protein-containing complex assembly [GO:0031333]; phosphorylation [GO:0016310]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22418843}.
O14732	reviewed	IMPA2_HUMAN	Inositol monophosphatase 2 (IMP 2) (IMPase 2) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 2) (Myo-inositol monophosphatase A2)	IMPA2 IMP.18P	Homo sapiens (Human)	288	FUNCTION: Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. {ECO:0000269|PubMed:17068342}.		inositol biosynthetic process [GO:0006021]; inositol metabolic process [GO:0006020]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; response to lithium ion [GO:0010226]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	inositol monophosphate 1-phosphatase activity [GO:0008934]; inositol monophosphate 3-phosphatase activity [GO:0052832]; inositol monophosphate 4-phosphatase activity [GO:0052833]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; inositol monophosphate 1-phosphatase activity [GO:0008934]; inositol monophosphate 3-phosphatase activity [GO:0052832]; inositol monophosphate 4-phosphatase activity [GO:0052833]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; inositol biosynthetic process [GO:0006021]; inositol metabolic process [GO:0006020]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; response to lithium ion [GO:0010226]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17068342}.
O14733	reviewed	MP2K7_HUMAN	Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)	MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4	Homo sapiens (Human)	419	FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}.	MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.	apoptotic process [GO:0006915]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; phosphorylation [GO:0016310]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of motor neuron apoptotic process [GO:2000671]; response to heat [GO:0009408]; response to osmotic stress [GO:0006970]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; JUN kinase kinase activity [GO:0008545]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; molecular function activator activity [GO:0140677]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; JUN kinase kinase activity [GO:0008545]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; molecular function activator activity [GO:0140677]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein tyrosine kinase activity [GO:0004713]; apoptotic process [GO:0006915]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; phosphorylation [GO:0016310]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of motor neuron apoptotic process [GO:2000671]; response to heat [GO:0009408]; response to osmotic stress [GO:0006970]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}.
O14734	reviewed	ACOT8_HUMAN	Acyl-coenzyme A thioesterase 8 (Acyl-CoA thioesterase 8) (EC 3.1.2.1) (EC 3.1.2.11) (EC 3.1.2.2) (EC 3.1.2.3) (EC 3.1.2.5) (Choloyl-coenzyme A thioesterase) (EC 3.1.2.27) (HIV-Nef-associated acyl-CoA thioesterase) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-CoA thioesterase 1) (Thioesterase II) (hACTE-III) (hACTEIII) (hTE)	ACOT8 ACTEIII PTE1	Homo sapiens (Human)	319	FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:9299485, PubMed:9153233, PubMed:15194431). Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:9299485, PubMed:9153233). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431). {ECO:0000250|UniProtKB:P58137, ECO:0000269|PubMed:15194431, ECO:0000269|PubMed:9153233, ECO:0000269|PubMed:9299485}.; FUNCTION: (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233). {ECO:0000269|PubMed:9153233}.		acyl-CoA metabolic process [GO:0006637]; alpha-linolenic acid metabolic process [GO:0036109]; bile acid biosynthetic process [GO:0006699]; dicarboxylic acid catabolic process [GO:0043649]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid catabolic process [GO:0009062]; negative regulation of CD4 production [GO:0045225]; peroxisome fission [GO:0016559]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]	acetoacetyl-CoA hydrolase activity [GO:0047603]; acetyl-CoA hydrolase activity [GO:0003986]; acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; choloyl-CoA hydrolase activity [GO:0033882]; CoA hydrolase activity [GO:0016289]; glutaryl-CoA hydrolase activity [GO:0044466]; hydroxymethylglutaryl-CoA hydrolase activity [GO:0047994]; medium-chain acyl-CoA hydrolase activity [GO:0052815]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; succinyl-CoA hydrolase activity [GO:0004778]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; acetoacetyl-CoA hydrolase activity [GO:0047603]; acetyl-CoA hydrolase activity [GO:0003986]; acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; choloyl-CoA hydrolase activity [GO:0033882]; CoA hydrolase activity [GO:0016289]; glutaryl-CoA hydrolase activity [GO:0044466]; hydroxymethylglutaryl-CoA hydrolase activity [GO:0047994]; medium-chain acyl-CoA hydrolase activity [GO:0052815]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; succinyl-CoA hydrolase activity [GO:0004778]; acyl-CoA metabolic process [GO:0006637]; alpha-linolenic acid metabolic process [GO:0036109]; bile acid biosynthetic process [GO:0006699]; dicarboxylic acid catabolic process [GO:0043649]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid catabolic process [GO:0009062]; negative regulation of CD4 production [GO:0045225]; peroxisome fission [GO:0016559]	SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000269|PubMed:10092594, ECO:0000269|PubMed:15194431}. Note=Predominantly localized in the peroxisome but a localization to the cytosol cannot be excluded. {ECO:0000269|PubMed:10092594, ECO:0000269|PubMed:15194431}.
O14735	reviewed	CDIPT_HUMAN	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase)	CDIPT PIS PIS1	Homo sapiens (Human)	213	FUNCTION: Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. {ECO:0000269|PubMed:8110188, ECO:0000269|PubMed:9407135}.		phosphatidylinositol biosynthetic process [GO:0006661]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity [GO:0003881]; metal ion binding [GO:0046872]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity [GO:0003881]; metal ion binding [GO:0046872]; phosphatidylinositol biosynthetic process [GO:0006661]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:8110188}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000305|PubMed:8110188}; Multi-pass membrane protein {ECO:0000255}.
O14737	reviewed	PDCD5_HUMAN	Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19)	PDCD5 TFAR19	Homo sapiens (Human)	125	FUNCTION: May function in the process of apoptosis.		apoptotic process [GO:0006915]; cellular response to transforming growth factor beta stimulus [GO:0071560]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chaperone-mediated protein folding [GO:1903645]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of gene expression [GO:0010628]; positive regulation of protein insertion into mitochondrial outer membrane [GO:1903638]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	acetyltransferase activator activity [GO:0010698]; beta-tubulin binding [GO:0048487]; DNA binding [GO:0003677]; heparin binding [GO:0008201]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; acetyltransferase activator activity [GO:0010698]; beta-tubulin binding [GO:0048487]; DNA binding [GO:0003677]; heparin binding [GO:0008201]; apoptotic process [GO:0006915]; cellular response to transforming growth factor beta stimulus [GO:0071560]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chaperone-mediated protein folding [GO:1903645]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of gene expression [GO:0010628]; positive regulation of protein insertion into mitochondrial outer membrane [GO:1903638]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]	
O14744	reviewed	ANM5_HUMAN	Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]	PRMT5 HRMT1L5 IBP72 JBP1 SKB1	Homo sapiens (Human)	637	FUNCTION: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951, PubMed:21081503). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805}.		circadian regulation of gene expression [GO:0032922]; DNA-templated transcription termination [GO:0006353]; endothelial cell activation [GO:0042118]; Golgi ribbon formation [GO:0090161]; liver regeneration [GO:0097421]; negative regulation of cell differentiation [GO:0045596]; peptidyl-arginine methylation [GO:0018216]; peptidyl-arginine N-methylation [GO:0035246]; positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:1904992]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA methylation [GO:0044030]; regulation of DNA-templated transcription [GO:0006355]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of mitotic nuclear division [GO:0007088]; regulation of signal transduction by p53 class mediator [GO:1901796]; spliceosomal snRNP assembly [GO:0000387]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone methyltransferase complex [GO:0035097]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	E-box binding [GO:0070888]; histone arginine N-methyltransferase activity [GO:0008469]; histone H3 methyltransferase activity [GO:0140938]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; methyltransferase activity [GO:0008168]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243]; ribonucleoprotein complex binding [GO:0043021]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone methyltransferase complex [GO:0035097]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; E-box binding [GO:0070888]; histone arginine N-methyltransferase activity [GO:0008469]; histone H3 methyltransferase activity [GO:0140938]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; methyltransferase activity [GO:0008168]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243]; ribonucleoprotein complex binding [GO:0043021]; transcription corepressor activity [GO:0003714]; circadian regulation of gene expression [GO:0032922]; DNA-templated transcription termination [GO:0006353]; endothelial cell activation [GO:0042118]; Golgi ribbon formation [GO:0090161]; liver regeneration [GO:0097421]; negative regulation of cell differentiation [GO:0045596]; peptidyl-arginine methylation [GO:0018216]; peptidyl-arginine N-methylation [GO:0035246]; positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:1904992]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA methylation [GO:0044030]; regulation of DNA-templated transcription [GO:0006355]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of mitotic nuclear division [GO:0007088]; regulation of signal transduction by p53 class mediator [GO:1901796]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951}. Nucleus {ECO:0000269|PubMed:18404153, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951}. Chromosome {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:33376131}. Golgi apparatus {ECO:0000269|PubMed:20421892}. Note=Localizes to promoter regions of target genes on chromosomes (PubMed:33376131). Localizes to methylated chromatin (PubMed:16428440). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:33376131}.
O14745	reviewed	NHRF1_HUMAN	Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)	NHERF1 NHERF SLC9A3R1	Homo sapiens (Human)	358	FUNCTION: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}.		actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; auditory receptor cell stereocilium organization [GO:0060088]; bile acid secretion [GO:0032782]; cerebrospinal fluid circulation [GO:0090660]; cilium organization [GO:0044782]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of Golgi localization [GO:0051683]; fibroblast migration [GO:0010761]; gamma-aminobutyric acid import [GO:0051939]; gland morphogenesis [GO:0022612]; glutathione transport [GO:0034635]; import across plasma membrane [GO:0098739]; intracellular phosphate ion homeostasis [GO:0030643]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; microvillus assembly [GO:0030033]; morphogenesis of an epithelium [GO:0002009]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of sodium ion transport [GO:0010766]; nuclear migration [GO:0007097]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; plasma membrane organization [GO:0007009]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; protein localization to plasma membrane [GO:0072659]; protein-containing complex assembly [GO:0065003]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of protein kinase activity [GO:0045859]; regulation of renal phosphate excretion [GO:1903402]; renal absorption [GO:0070293]; renal phosphate ion absorption [GO:0097291]; renal sodium ion transport [GO:0003096]; sensory perception of sound [GO:0007605]; transport across blood-brain barrier [GO:0150104]; Wnt signaling pathway [GO:0016055]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; membrane [GO:0016020]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane protein complex [GO:0098797]; ruffle [GO:0001726]; sperm midpiece [GO:0097225]; stereocilium tip [GO:0032426]; vesicle [GO:0031982]	beta-2 adrenergic receptor binding [GO:0031698]; beta-catenin binding [GO:0008013]; channel activator activity [GO:0099103]; chloride channel regulator activity [GO:0017081]; dopamine receptor binding [GO:0050780]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; growth factor receptor binding [GO:0070851]; identical protein binding [GO:0042802]; myosin II binding [GO:0045159]; PDZ domain binding [GO:0030165]; phosphatase binding [GO:0019902]; protein self-association [GO:0043621]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; type 2 metabotropic glutamate receptor binding [GO:0031799]; type 3 metabotropic glutamate receptor binding [GO:0031800]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; membrane [GO:0016020]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane protein complex [GO:0098797]; ruffle [GO:0001726]; sperm midpiece [GO:0097225]; stereocilium tip [GO:0032426]; vesicle [GO:0031982]; beta-2 adrenergic receptor binding [GO:0031698]; beta-catenin binding [GO:0008013]; channel activator activity [GO:0099103]; chloride channel regulator activity [GO:0017081]; dopamine receptor binding [GO:0050780]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; growth factor receptor binding [GO:0070851]; identical protein binding [GO:0042802]; myosin II binding [GO:0045159]; PDZ domain binding [GO:0030165]; phosphatase binding [GO:0019902]; protein self-association [GO:0043621]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; type 2 metabotropic glutamate receptor binding [GO:0031799]; type 3 metabotropic glutamate receptor binding [GO:0031800]; actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; auditory receptor cell stereocilium organization [GO:0060088]; bile acid secretion [GO:0032782]; cerebrospinal fluid circulation [GO:0090660]; cilium organization [GO:0044782]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of Golgi localization [GO:0051683]; fibroblast migration [GO:0010761]; gamma-aminobutyric acid import [GO:0051939]; gland morphogenesis [GO:0022612]; glutathione transport [GO:0034635]; import across plasma membrane [GO:0098739]; intracellular phosphate ion homeostasis [GO:0030643]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; microvillus assembly [GO:0030033]; morphogenesis of an epithelium [GO:0002009]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of sodium ion transport [GO:0010766]; nuclear migration [GO:0007097]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; plasma membrane organization [GO:0007009]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; protein localization to plasma membrane [GO:0072659]; protein-containing complex assembly [GO:0065003]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of protein kinase activity [GO:0045859]; regulation of renal phosphate excretion [GO:1903402]; renal absorption [GO:0070293]; renal phosphate ion absorption [GO:0097291]; renal sodium ion transport [GO:0003096]; sensory perception of sound [GO:0007605]; transport across blood-brain barrier [GO:0150104]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Apical cell membrane {ECO:0000250}. Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Note=Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T-cells. {ECO:0000250}.
O14746	reviewed	TERT_HUMAN	Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2)	TERT EST2 TCS1 TRT	Homo sapiens (Human)	1132	FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. {ECO:0000269|PubMed:14963003, ECO:0000269|PubMed:15082768, ECO:0000269|PubMed:15857955, ECO:0000269|PubMed:17026956, ECO:0000269|PubMed:17264120, ECO:0000269|PubMed:17296728, ECO:0000269|PubMed:17548608, ECO:0000269|PubMed:19188162, ECO:0000269|PubMed:19567472, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:19777057, ECO:0000269|PubMed:9389643}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to hypoxia [GO:0071456]; DNA biosynthetic process [GO:0071897]; DNA strand elongation [GO:0022616]; establishment of protein localization to telomere [GO:0070200]; mitochondrion organization [GO:0007005]; negative regulation of cellular senescence [GO:2000773]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of angiogenesis [GO:0045766]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of glucose import [GO:0046326]; positive regulation of hair cycle [GO:0042635]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transdifferentiation [GO:1903620]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of protein stability [GO:0031647]; replicative senescence [GO:0090399]; response to cadmium ion [GO:0046686]; RNA-templated DNA biosynthetic process [GO:0006278]; RNA-templated transcription [GO:0001172]; siRNA processing [GO:0030422]; siRNA transcription [GO:0140745]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; nuclear speck [GO:0016607]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; RNA-directed RNA polymerase complex [GO:0031379]; telomerase catalytic core complex [GO:0000333]; telomerase holoenzyme complex [GO:0005697]; TERT-RMRP complex [GO:1990572]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; RNA-dependent RNA polymerase activity [GO:0003968]; RNA-directed DNA polymerase activity [GO:0003964]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034]; telomerase RNA reverse transcriptase activity [GO:0003721]; telomeric DNA binding [GO:0042162]; template-free RNA nucleotidyltransferase [GO:0098680]; transcription coactivator binding [GO:0001223]; tRNA binding [GO:0000049]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; nuclear speck [GO:0016607]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; RNA-directed RNA polymerase complex [GO:0031379]; telomerase catalytic core complex [GO:0000333]; telomerase holoenzyme complex [GO:0005697]; TERT-RMRP complex [GO:1990572]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; RNA-dependent RNA polymerase activity [GO:0003968]; RNA-directed DNA polymerase activity [GO:0003964]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034]; telomerase RNA reverse transcriptase activity [GO:0003721]; telomeric DNA binding [GO:0042162]; template-free RNA nucleotidyltransferase [GO:0098680]; transcription coactivator binding [GO:0001223]; tRNA binding [GO:0000049]; cellular response to hypoxia [GO:0071456]; DNA biosynthetic process [GO:0071897]; DNA strand elongation [GO:0022616]; establishment of protein localization to telomere [GO:0070200]; mitochondrion organization [GO:0007005]; negative regulation of cellular senescence [GO:2000773]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of angiogenesis [GO:0045766]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of glucose import [GO:0046326]; positive regulation of hair cycle [GO:0042635]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transdifferentiation [GO:1903620]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of protein stability [GO:0031647]; replicative senescence [GO:0090399]; response to cadmium ion [GO:0046686]; RNA-templated DNA biosynthetic process [GO:0006278]; RNA-templated transcription [GO:0001172]; siRNA processing [GO:0030422]; siRNA transcription [GO:0140745]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:22226966}. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body. Note=Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress-mediated phosphorylation at Tyr-707. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT.
O14756	reviewed	H17B6_HUMAN	17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.239) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 6)	HSD17B6 RODH SDR9C6	Homo sapiens (Human)	317	FUNCTION: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. {ECO:0000269|PubMed:10896656, ECO:0000269|PubMed:11360992, ECO:0000269|PubMed:11513953}.		androgen biosynthetic process [GO:0006702]; androgen catabolic process [GO:0006710]; brexanolone catabolic process [GO:0062175]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]	early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]	5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; catalytic activity [GO:0003824]; electron transfer activity [GO:0009055]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; NAD-retinol dehydrogenase activity [GO:0004745]; oxidoreductase activity [GO:0016491]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase (NAD+) activity [GO:0047035]	early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; catalytic activity [GO:0003824]; electron transfer activity [GO:0009055]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; NAD-retinol dehydrogenase activity [GO:0004745]; oxidoreductase activity [GO:0016491]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; androgen biosynthetic process [GO:0006702]; androgen catabolic process [GO:0006710]; brexanolone catabolic process [GO:0062175]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:11360992}; Peripheral membrane protein {ECO:0000269|PubMed:11360992}; Lumenal side {ECO:0000269|PubMed:11360992}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Lumenal side {ECO:0000305}.
O14757	reviewed	CHK1_HUMAN	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)	CHEK1 CHK1	Homo sapiens (Human)	476	FUNCTION: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047, PubMed:32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:9278511, PubMed:12676583, PubMed:14681206, PubMed:12676925, PubMed:12759351, PubMed:19734889, PubMed:14559997). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:9278511, PubMed:12676583, PubMed:14681206, PubMed:12676925, PubMed:12759351, PubMed:19734889). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:9278511, PubMed:19734889, PubMed:20090422). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). {ECO:0000250|UniProtKB:O35280, ECO:0000269|PubMed:10673501, ECO:0000269|PubMed:11535615, ECO:0000269|PubMed:12399544, ECO:0000269|PubMed:12446774, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12676583, ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:12759351, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988723, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15650047, ECO:0000269|PubMed:15659650, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:17296736, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:18451105, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9278511}.; FUNCTION: [Isoform 2]: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition. {ECO:0000269|PubMed:22184239}.		apoptotic process [GO:0006915]; apoptotic process involved in development [GO:1902742]; cellular response to caffeine [GO:0071313]; cellular response to mechanical stimulus [GO:0071260]; chromatin remodeling [GO:0006338]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; G2/M transition of mitotic cell cycle [GO:0000086]; inner cell mass cell proliferation [GO:0001833]; intracellular signal transduction [GO:0035556]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of mitotic nuclear division [GO:0045839]; nucleus organization [GO:0006997]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cell cycle [GO:0045787]; protein phosphorylation [GO:0006468]; regulation of cell population proliferation [GO:0042127]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of mitotic centrosome separation [GO:0046602]; regulation of signal transduction by p53 class mediator [GO:1901796]; replicative senescence [GO:0090399]; signal transduction in response to DNA damage [GO:0042770]	centrosome [GO:0005813]; chromatin [GO:0000785]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; replication fork [GO:0005657]	ATP binding [GO:0005524]; histone H3T11 kinase activity [GO:0035402]; protein domain specific binding [GO:0019904]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; chromatin [GO:0000785]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; replication fork [GO:0005657]; ATP binding [GO:0005524]; histone H3T11 kinase activity [GO:0035402]; protein domain specific binding [GO:0019904]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; apoptotic process involved in development [GO:1902742]; cellular response to caffeine [GO:0071313]; cellular response to mechanical stimulus [GO:0071260]; chromatin remodeling [GO:0006338]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; G2/M transition of mitotic cell cycle [GO:0000086]; inner cell mass cell proliferation [GO:0001833]; intracellular signal transduction [GO:0035556]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of mitotic nuclear division [GO:0045839]; nucleus organization [GO:0006997]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cell cycle [GO:0045787]; protein phosphorylation [GO:0006468]; regulation of cell population proliferation [GO:0042127]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of mitotic centrosome separation [GO:0046602]; regulation of signal transduction by p53 class mediator [GO:1901796]; replicative senescence [GO:0090399]; signal transduction in response to DNA damage [GO:0042770]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12676962, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15710331, ECO:0000269|PubMed:9278511}. Chromosome {ECO:0000269|PubMed:12676962, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:9382850}. Cytoplasm {ECO:0000269|PubMed:12676962}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15311285}. Note=Nuclear export is mediated at least in part by XPO1/CRM1 (PubMed:12676962). Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B (PubMed:15311285). Proteolytic cleavage at the C-terminus by SPRTN promotes removal from chromatin (PubMed:31316063). {ECO:0000269|PubMed:12676962, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:31316063}.
O14763	reviewed	TR10B_HUMAN	Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)	TNFRSF10B DR5 KILLER TRAILR2 TRICK2 ZTNFR9 UNQ160/PRO186	Homo sapiens (Human)	440	FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:10542098, ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:15322075}.	MISCELLANEOUS: [Isoform Long]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform Short]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cellular response to mechanical stimulus [GO:0071260]; defense response to tumor cell [GO:0002357]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of apoptotic process [GO:0042981]; response to endoplasmic reticulum stress [GO:0034976]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]; TRAIL binding [GO:0045569]; TRAIL receptor activity [GO:0036463]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; TRAIL binding [GO:0045569]; TRAIL receptor activity [GO:0036463]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cellular response to mechanical stimulus [GO:0071260]; defense response to tumor cell [GO:0002357]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of apoptotic process [GO:0042981]; response to endoplasmic reticulum stress [GO:0034976]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
O14764	reviewed	GBRD_HUMAN	Gamma-aminobutyric acid receptor subunit delta (GABA(A) receptor subunit delta)	GABRD	Homo sapiens (Human)	452	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.		chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]	axon [GO:0030424]; chloride channel complex [GO:0034707]; dendrite [GO:0030425]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	axon [GO:0030424]; chloride channel complex [GO:0034707]; dendrite [GO:0030425]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
O14770	reviewed	MEIS2_HUMAN	Homeobox protein Meis2 (Meis1-related protein 1)	MEIS2 MRG1	Homo sapiens (Human)	477	FUNCTION: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. {ECO:0000269|PubMed:10764806, ECO:0000269|PubMed:11279116, ECO:0000269|PubMed:21746878}.		animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pancreas development [GO:0031016]; positive regulation of cardiac muscle myoblast proliferation [GO:0110024]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to growth factor [GO:0070848]; response to mechanical stimulus [GO:0009612]; visual learning [GO:0008542]	chromatin [GO:0000785]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription factor binding [GO:0008134]	chromatin [GO:0000785]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription factor binding [GO:0008134]; animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pancreas development [GO:0031016]; positive regulation of cardiac muscle myoblast proliferation [GO:0110024]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to growth factor [GO:0070848]; response to mechanical stimulus [GO:0009612]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P97367}.
O14771	reviewed	ZN213_HUMAN	Zinc finger protein 213 (Putative transcription factor CR53) (Zinc finger protein with KRAB and SCAN domains 21)	ZNF213 ZKSCAN21	Homo sapiens (Human)	459	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
O14772	reviewed	FPGT_HUMAN	Fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) (GDP-L-fucose diphosphorylase) (GDP-L-fucose pyrophosphorylase)	FPGT GFPP	Homo sapiens (Human)	607	FUNCTION: Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate (PubMed:9804772). Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids (PubMed:9804772). {ECO:0000269|PubMed:9804772}.		fucose metabolic process [GO:0006004]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	catalytic activity [GO:0003824]; fucose-1-phosphate guanylyltransferase activity [GO:0047341]; GTP binding [GO:0005525]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; catalytic activity [GO:0003824]; fucose-1-phosphate guanylyltransferase activity [GO:0047341]; GTP binding [GO:0005525]; fucose metabolic process [GO:0006004]	SUBCELLULAR LOCATION: Cytoplasm.
O14773	reviewed	TPP1_HUMAN	Tripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Cell growth-inhibiting gene 1 protein) (Lysosomal pepstatin-insensitive protease) (LPIC) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I)	TPP1 CLN2 GIG1 UNQ267/PRO304	Homo sapiens (Human)	563	FUNCTION: Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:11054422, PubMed:19038966, PubMed:19038967). May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (PubMed:11054422, PubMed:19038966, PubMed:19038967). Requires substrates with an unsubstituted N-terminus (PubMed:19038966). {ECO:0000269|PubMed:11054422, ECO:0000269|PubMed:19038966, ECO:0000269|PubMed:19038967}.		bone resorption [GO:0045453]; central nervous system development [GO:0007417]; epithelial cell differentiation [GO:0030855]; lipid metabolic process [GO:0006629]; lysosomal protein catabolic process [GO:1905146]; lysosome organization [GO:0007040]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; peptide catabolic process [GO:0043171]; protein catabolic process [GO:0030163]; protein localization to chromosome, telomeric region [GO:0070198]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane raft [GO:0045121]; recycling endosome [GO:0055037]	endopeptidase activity [GO:0004175]; lysophosphatidic acid binding [GO:0035727]; metal ion binding [GO:0046872]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; sulfatide binding [GO:0120146]; tripeptidyl-peptidase activity [GO:0008240]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane raft [GO:0045121]; recycling endosome [GO:0055037]; endopeptidase activity [GO:0004175]; lysophosphatidic acid binding [GO:0035727]; metal ion binding [GO:0046872]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; sulfatide binding [GO:0120146]; tripeptidyl-peptidase activity [GO:0008240]; bone resorption [GO:0045453]; central nervous system development [GO:0007417]; epithelial cell differentiation [GO:0030855]; lipid metabolic process [GO:0006629]; lysosomal protein catabolic process [GO:1905146]; lysosome organization [GO:0007040]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; peptide catabolic process [GO:0043171]; protein catabolic process [GO:0030163]; protein localization to chromosome, telomeric region [GO:0070198]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:19941651}. Melanosome {ECO:0000269|PubMed:12643545}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545}.
O14775	reviewed	GNB5_HUMAN	Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5)	GNB5	Homo sapiens (Human)	395	FUNCTION: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (PubMed:27677260). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). {ECO:0000250|UniProtKB:A1L271, ECO:0000250|UniProtKB:P62881, ECO:0000269|PubMed:27677260}.		dark adaptation [GO:1990603]; dopamine receptor signaling pathway [GO:0007212]; G protein-coupled receptor signaling pathway [GO:0007186]; light adaption [GO:0036367]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTPase activator complex [GO:1902773]; heterotrimeric G-protein complex [GO:0005834]; nucleus [GO:0005634]; presynapse [GO:0098793]	G-protein gamma-subunit binding [GO:0031682]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; protein-folding chaperone binding [GO:0051087]; signaling receptor complex adaptor activity [GO:0030159]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTPase activator complex [GO:1902773]; heterotrimeric G-protein complex [GO:0005834]; nucleus [GO:0005634]; presynapse [GO:0098793]; G-protein gamma-subunit binding [GO:0031682]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; protein-folding chaperone binding [GO:0051087]; signaling receptor complex adaptor activity [GO:0030159]; dark adaptation [GO:1990603]; dopamine receptor signaling pathway [GO:0007212]; G protein-coupled receptor signaling pathway [GO:0007186]; light adaption [GO:0036367]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P62881}.
O14776	reviewed	TCRG1_HUMAN	Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150)	TCERG1 CA150 TAF2S	Homo sapiens (Human)	1098	FUNCTION: Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. {ECO:0000269|PubMed:11604498, ECO:0000269|PubMed:9315662}.		mRNA processing [GO:0006397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; transcription elongation factor activity [GO:0003711]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; transcription elongation factor activity [GO:0003711]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; mRNA processing [GO:0006397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10908677, ECO:0000269|PubMed:15485897, ECO:0000269|PubMed:9315662}.
O14777	reviewed	NDC80_HUMAN	Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)	NDC80 HEC HEC1 KNTC2	Homo sapiens (Human)	642	FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}.		attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; centrosome duplication [GO:0051298]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; G2/MI transition of meiotic cell cycle [GO:0008315]; kinetochore organization [GO:0051383]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of protein stability [GO:0031647]; skeletal muscle satellite cell proliferation [GO:0014841]; spindle assembly involved in female meiosis I [GO:0007057]	centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; Ndc80 complex [GO:0031262]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]	cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; kinetochore adaptor activity [GO:0140483]	centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; Ndc80 complex [GO:0031262]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; kinetochore adaptor activity [GO:0140483]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; centrosome duplication [GO:0051298]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; G2/MI transition of meiotic cell cycle [GO:0008315]; kinetochore organization [GO:0051383]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of protein stability [GO:0031647]; skeletal muscle satellite cell proliferation [GO:0014841]; spindle assembly involved in female meiosis I [GO:0007057]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9315664}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14699129}. Note=Localizes to kinetochores from late prophase to anaphase (PubMed:14699129). Localizes specifically to the outer plate of the kinetochore (PubMed:14699129). {ECO:0000269|PubMed:14699129}.
O14782	reviewed	KIF3C_HUMAN	Kinesin-like protein KIF3C	KIF3C	Homo sapiens (Human)	793	FUNCTION: Microtubule-based anterograde translocator for membranous organelles. {ECO:0000250}.		microtubule-based movement [GO:0007018]	ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
O14786	reviewed	NRP1_HUMAN	Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)	NRP1 NRP VEGF165R	Homo sapiens (Human)	923	FUNCTION: Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed:9288753, PubMed:9529250, PubMed:10688880). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:9288753, PubMed:9529250, PubMed:10688880, PubMed:19805273). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799). {ECO:0000250|UniProtKB:P97333, ECO:0000269|PubMed:10688880, ECO:0000269|PubMed:19805273, ECO:0000269|PubMed:30623799, ECO:0000269|PubMed:9288753, ECO:0000269|PubMed:9529250}.; FUNCTION: (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection. {ECO:0000269|PubMed:33082293, ECO:0000269|PubMed:33082294}.; FUNCTION: [Isoform 2]: Binds VEGF-165 and may inhibit its binding to cells (PubMed:10748121, PubMed:26503042). May induce apoptosis by sequestering VEGF-165 (PubMed:10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. {ECO:0000269|PubMed:10748121, ECO:0000269|PubMed:26503042}.		angiogenesis [GO:0001525]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; animal organ morphogenesis [GO:0009887]; artery morphogenesis [GO:0048844]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis involved in innervation [GO:0060385]; basal dendrite arborization [GO:0150020]; basal dendrite development [GO:0150018]; branching involved in blood vessel morphogenesis [GO:0001569]; branchiomotor neuron axon guidance [GO:0021785]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-cell signaling [GO:0007267]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; commissural neuron axon guidance [GO:0071679]; coronary artery morphogenesis [GO:0060982]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; dorsal root ganglion morphogenesis [GO:1904835]; endothelial cell chemotaxis [GO:0035767]; endothelial cell migration [GO:0043542]; endothelial tip cell fate specification [GO:0097102]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; integrin-mediated signaling pathway [GO:0007229]; motor neuron migration [GO:0097475]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; neuropilin signaling pathway [GO:0038189]; otic placode development [GO:1905040]; outflow tract septum morphogenesis [GO:0003148]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive chemotaxis [GO:0050918]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cytokine activity [GO:0060301]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphorylation [GO:0042327]; positive regulation of retinal ganglion cell axon guidance [GO:1902336]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynapse organization [GO:0099173]; protein localization to early endosome [GO:1902946]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of retinal ganglion cell axon guidance [GO:0090259]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; regulation of vesicle-mediated transport [GO:0060627]; renal artery morphogenesis [GO:0061441]; response to wounding [GO:0009611]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal ganglion cell axon guidance [GO:0031290]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sensory neuron axon guidance [GO:0097374]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; substrate-dependent cell migration, cell extension [GO:0006930]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; trigeminal nerve structural organization [GO:0021637]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vasculogenesis [GO:0001570]; VEGF-activated neuropilin signaling pathway [GO:0038190]; VEGF-activated neuropilin signaling pathway involved in axon guidance [GO:1902378]; ventral trunk neural crest cell migration [GO:0036486]; vestibulocochlear nerve structural organization [GO:0021649]; viral entry into host cell [GO:0046718]	axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; mitochondrial membrane [GO:0031966]; neurofilament [GO:0005883]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; receptor complex [GO:0043235]; semaphorin receptor complex [GO:0002116]; sorting endosome [GO:0097443]	coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; GTPase activator activity [GO:0005096]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; semaphorin receptor activity [GO:0017154]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021]	axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; mitochondrial membrane [GO:0031966]; neurofilament [GO:0005883]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; receptor complex [GO:0043235]; semaphorin receptor complex [GO:0002116]; sorting endosome [GO:0097443]; coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; GTPase activator activity [GO:0005096]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; semaphorin receptor activity [GO:0017154]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021]; angiogenesis [GO:0001525]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; animal organ morphogenesis [GO:0009887]; artery morphogenesis [GO:0048844]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis involved in innervation [GO:0060385]; basal dendrite arborization [GO:0150020]; basal dendrite development [GO:0150018]; branching involved in blood vessel morphogenesis [GO:0001569]; branchiomotor neuron axon guidance [GO:0021785]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-cell signaling [GO:0007267]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; commissural neuron axon guidance [GO:0071679]; coronary artery morphogenesis [GO:0060982]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; dorsal root ganglion morphogenesis [GO:1904835]; endothelial cell chemotaxis [GO:0035767]; endothelial cell migration [GO:0043542]; endothelial tip cell fate specification [GO:0097102]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; integrin-mediated signaling pathway [GO:0007229]; motor neuron migration [GO:0097475]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; neuropilin signaling pathway [GO:0038189]; otic placode development [GO:1905040]; outflow tract septum morphogenesis [GO:0003148]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive chemotaxis [GO:0050918]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cytokine activity [GO:0060301]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphorylation [GO:0042327]; positive regulation of retinal ganglion cell axon guidance [GO:1902336]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynapse organization [GO:0099173]; protein localization to early endosome [GO:1902946]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of retinal ganglion cell axon guidance [GO:0090259]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; regulation of vesicle-mediated transport [GO:0060627]; renal artery morphogenesis [GO:0061441]; response to wounding [GO:0009611]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal ganglion cell axon guidance [GO:0031290]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sensory neuron axon guidance [GO:0097374]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; substrate-dependent cell migration, cell extension [GO:0006930]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; trigeminal nerve structural organization [GO:0021637]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vasculogenesis [GO:0001570]; VEGF-activated neuropilin signaling pathway [GO:0038190]; VEGF-activated neuropilin signaling pathway involved in axon guidance [GO:1902378]; ventral trunk neural crest cell migration [GO:0036486]; vestibulocochlear nerve structural organization [GO:0021649]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:10688880}.; SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305|PubMed:30623799}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30623799}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:30623799}.
O14787	reviewed	TNPO2_HUMAN	Transportin-2 (Karyopherin beta-2b)	TNPO2	Homo sapiens (Human)	897	FUNCTION: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO:0000250}.		protein import into nucleus [GO:0006606]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
O14788	reviewed	TNF11_HUMAN	Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]	TNFSF11 OPGL RANKL TRANCE	Homo sapiens (Human)	317	FUNCTION: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity). {ECO:0000250|UniProtKB:O35235, ECO:0000269|PubMed:22664871}.		bone resorption [GO:0045453]; calcium ion homeostasis [GO:0055074]; calcium-mediated signaling [GO:0019722]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to leukemia inhibitory factor [GO:1990830]; cytokine-mediated signaling pathway [GO:0019221]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; JNK cascade [GO:0007254]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell proliferation [GO:0033598]; monocyte chemotaxis [GO:0002548]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification [GO:0001503]; osteoclast development [GO:0036035]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; paracrine signaling [GO:0038001]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of corticotropin-releasing hormone secretion [GO:0051466]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling [GO:0071848]; positive regulation of fever generation by positive regulation of prostaglandin secretion [GO:0071812]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoclast development [GO:2001206]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of T cell activation [GO:0050870]; positive regulation of transcription by RNA polymerase II [GO:0045944]; TNFSF11-mediated signaling pathway [GO:0071847]; tooth eruption [GO:0044691]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]; bone resorption [GO:0045453]; calcium ion homeostasis [GO:0055074]; calcium-mediated signaling [GO:0019722]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to leukemia inhibitory factor [GO:1990830]; cytokine-mediated signaling pathway [GO:0019221]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; JNK cascade [GO:0007254]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell proliferation [GO:0033598]; monocyte chemotaxis [GO:0002548]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification [GO:0001503]; osteoclast development [GO:0036035]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; paracrine signaling [GO:0038001]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of corticotropin-releasing hormone secretion [GO:0051466]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling [GO:0071848]; positive regulation of fever generation by positive regulation of prostaglandin secretion [GO:0071812]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoclast development [GO:2001206]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of T cell activation [GO:0050870]; positive regulation of transcription by RNA polymerase II [GO:0045944]; TNFSF11-mediated signaling pathway [GO:0071847]; tooth eruption [GO:0044691]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted {ECO:0000250}.
O14791	reviewed	APOL1_HUMAN	Apolipoprotein L1 (Apolipoprotein L) (Apo-L) (ApoL) (Apolipoprotein L-I) (ApoL-I)	APOL1 APOL	Homo sapiens (Human)	398	FUNCTION: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.	MISCELLANEOUS: [Isoform 1]: Major isoform.	chloride transmembrane transport [GO:1902476]; cholesterol metabolic process [GO:0008203]; cytolysis by host of symbiont cells [GO:0051838]; innate immune response [GO:0045087]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]	blood microparticle [GO:0072562]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; membrane [GO:0016020]; very-low-density lipoprotein particle [GO:0034361]	chloride channel activity [GO:0005254]; lipid binding [GO:0008289]	blood microparticle [GO:0072562]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; membrane [GO:0016020]; very-low-density lipoprotein particle [GO:0034361]; chloride channel activity [GO:0005254]; lipid binding [GO:0008289]; chloride transmembrane transport [GO:1902476]; cholesterol metabolic process [GO:0008203]; cytolysis by host of symbiont cells [GO:0051838]; innate immune response [GO:0045087]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]	SUBCELLULAR LOCATION: Secreted.
O14792	reviewed	HS3S1_HUMAN	Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1)	HS3ST1 3OST 3OST1	Homo sapiens (Human)	307	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:9346953, PubMed:8900198, PubMed:9988768). Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:8900198, PubMed:9988768). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (PubMed:8900198, PubMed:9988768). {ECO:0000269|PubMed:8900198, ECO:0000269|PubMed:9346953, ECO:0000269|PubMed:9988768}.		glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	Golgi lumen [GO:0005796]	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; sulfotransferase activity [GO:0008146]	Golgi lumen [GO:0005796]; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; sulfotransferase activity [GO:0008146]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	SUBCELLULAR LOCATION: Golgi apparatus lumen {ECO:0000305}.
O14793	reviewed	GDF8_HUMAN	Growth/differentiation factor 8 (GDF-8) (Myostatin)	MSTN GDF8	Homo sapiens (Human)	375	FUNCTION: Acts specifically as a negative regulator of skeletal muscle growth. {ECO:0000250|UniProtKB:O08689}.		cellular response to dexamethasone stimulus [GO:0071549]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of muscle hypertrophy [GO:0014741]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myoblast proliferation [GO:2000818]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; negative regulation of skeletal muscle tissue growth [GO:0048632]; ovulation cycle process [GO:0022602]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of macrophage chemotaxis [GO:0010759]; response to electrical stimulus [GO:0051602]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to gravity [GO:0009629]; response to muscle activity [GO:0014850]; response to testosterone [GO:0033574]; skeletal muscle atrophy [GO:0014732]; skeletal muscle satellite cell differentiation [GO:0014816]; transforming growth factor beta receptor signaling pathway [GO:0007179]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; cellular response to dexamethasone stimulus [GO:0071549]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of muscle hypertrophy [GO:0014741]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myoblast proliferation [GO:2000818]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; negative regulation of skeletal muscle tissue growth [GO:0048632]; ovulation cycle process [GO:0022602]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of macrophage chemotaxis [GO:0010759]; response to electrical stimulus [GO:0051602]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to gravity [GO:0009629]; response to muscle activity [GO:0014850]; response to testosterone [GO:0033574]; skeletal muscle atrophy [GO:0014732]; skeletal muscle satellite cell differentiation [GO:0014816]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O08689}.
O14795	reviewed	UN13B_HUMAN	Protein unc-13 homolog B (Munc13-2) (munc13)	UNC13B UNC13	Homo sapiens (Human)	1591	FUNCTION: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}.		acrosomal vesicle exocytosis [GO:0060478]; cellular response to glucose stimulus [GO:0071333]; chemical synaptic transmission [GO:0007268]; dense core granule priming [GO:0061789]; neuromuscular junction development [GO:0007528]; neuronal dense core vesicle exocytosis [GO:0099011]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of protein secretion [GO:0050714]; positive regulation of synaptic vesicle priming [GO:0010808]; presynaptic dense core vesicle exocytosis [GO:0099525]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle priming [GO:0016082]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; GTP-dependent protein binding [GO:0030742]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]; syntaxin-1 binding [GO:0017075]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; GTP-dependent protein binding [GO:0030742]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]; syntaxin-1 binding [GO:0017075]; acrosomal vesicle exocytosis [GO:0060478]; cellular response to glucose stimulus [GO:0071333]; chemical synaptic transmission [GO:0007268]; dense core granule priming [GO:0061789]; neuromuscular junction development [GO:0007528]; neuronal dense core vesicle exocytosis [GO:0099011]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of protein secretion [GO:0050714]; positive regulation of synaptic vesicle priming [GO:0010808]; presynaptic dense core vesicle exocytosis [GO:0099525]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle priming [GO:0016082]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}. Synapse {ECO:0000250}. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). {ECO:0000250}.
O14796	reviewed	SH21B_HUMAN	SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)	SH2D1B EAT2	Homo sapiens (Human)	132	FUNCTION: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity). {ECO:0000250|UniProtKB:O35324, ECO:0000269|PubMed:11689425, ECO:0000269|PubMed:24687958, ECO:0000305|PubMed:21219180}.		adaptive immune response [GO:0002250]; innate immune response [GO:0045087]; leukocyte activation involved in immune response [GO:0002366]; positive regulation of innate immune response [GO:0045089]; positive regulation of natural killer cell mediated immunity [GO:0002717]	cytosol [GO:0005829]	protein-macromolecule adaptor activity [GO:0030674]	cytosol [GO:0005829]; protein-macromolecule adaptor activity [GO:0030674]; adaptive immune response [GO:0002250]; innate immune response [GO:0045087]; leukocyte activation involved in immune response [GO:0002366]; positive regulation of innate immune response [GO:0045089]; positive regulation of natural killer cell mediated immunity [GO:0002717]	
O14798	reviewed	TR10C_HUMAN	Tumor necrosis factor receptor superfamily member 10C (Antagonist decoy receptor for TRAIL/Apo-2L) (Decoy TRAIL receptor without death domain) (Decoy receptor 1) (DcR1) (Lymphocyte inhibitor of TRAIL) (TNF-related apoptosis-inducing ligand receptor 3) (TRAIL receptor 3) (TRAIL-R3) (TRAIL receptor without an intracellular domain) (CD antigen CD263)	TNFRSF10C DCR1 LIT TRAILR3 TRID UNQ321/PRO366	Homo sapiens (Human)	259	FUNCTION: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.		positive regulation of apoptotic process [GO:0043065]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	TRAIL binding [GO:0045569]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; TRAIL binding [GO:0045569]; transmembrane signaling receptor activity [GO:0004888]; positive regulation of apoptotic process [GO:0043065]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
O14802	reviewed	RPC1_HUMAN	DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)	POLR3A	Homo sapiens (Human)	1390	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. {ECO:0000250, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370}.		defense response to virus [GO:0051607]; DNA-templated transcription [GO:0006351]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; transcription by RNA polymerase III [GO:0006383]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; defense response to virus [GO:0051607]; DNA-templated transcription [GO:0006351]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11416169}.
O14804	reviewed	TAAR5_HUMAN	Trace amine-associated receptor 5 (TaR-5) (Trace amine receptor 5) (hTaar5) (Putative neurotransmitter receptor)	TAAR5 PNR	Homo sapiens (Human)	337	FUNCTION: Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase. {ECO:0000269|PubMed:23393561}.	MISCELLANEOUS: Polymorphic variants of this gene are not associated with specific anosmia for trimethylamine. {ECO:0000305|PubMed:23393561}.	G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]; trimethylamine receptor activity [GO:1990081]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]; trimethylamine receptor activity [GO:1990081]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23393561}; Multi-pass membrane protein {ECO:0000269|PubMed:23393561}.
O14807	reviewed	RASM_HUMAN	Ras-related protein M-Ras (EC 3.6.5.2) (Ras-related protein R-Ras3)	MRAS RRAS3	Homo sapiens (Human)	208	FUNCTION: Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway. {ECO:0000269|PubMed:16630891, ECO:0000269|PubMed:28289718}.		actin cytoskeleton organization [GO:0030036]; cellular response to leukemia inhibitory factor [GO:1990830]; Ras protein signal transduction [GO:0007265]	plasma membrane [GO:0005886]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; actin cytoskeleton organization [GO:0030036]; cellular response to leukemia inhibitory factor [GO:1990830]; Ras protein signal transduction [GO:0007265]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
O14810	reviewed	CPLX1_HUMAN	Complexin-1 (Complexin I) (CPX I) (Synaphin-2)	CPLX1	Homo sapiens (Human)	134	FUNCTION: Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. {ECO:0000250|UniProtKB:P63040, ECO:0000269|PubMed:21785414}.		chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]; regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane [GO:0099145]; regulation of exocytosis [GO:0017157]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; synaptic vesicle exocytosis [GO:0016079]	calyx of Held [GO:0044305]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685]; SNARE complex [GO:0031201]; synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex [GO:0070554]; terminal bouton [GO:0043195]	neurotransmitter transmembrane transporter activity [GO:0005326]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]	calyx of Held [GO:0044305]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685]; SNARE complex [GO:0031201]; synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex [GO:0070554]; terminal bouton [GO:0043195]; neurotransmitter transmembrane transporter activity [GO:0005326]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]; regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane [GO:0099145]; regulation of exocytosis [GO:0017157]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; synaptic vesicle exocytosis [GO:0016079]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P63040}. Perikaryon {ECO:0000250|UniProtKB:P63040}. Presynapse {ECO:0000250|UniProtKB:P63040}. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250|UniProtKB:P63040}.
O14813	reviewed	PHX2A_HUMAN	Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A)	PHOX2A ARIX PMX2A	Homo sapiens (Human)	284	FUNCTION: May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.		dopaminergic neuron differentiation [GO:0071542]; locus ceruleus development [GO:0021703]; midbrain development [GO:0030901]; noradrenergic neuron differentiation [GO:0003357]; oculomotor nerve formation [GO:0021623]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of respiratory gaseous exchange [GO:0043576]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic motor neuron differentiation [GO:0021523]; sympathetic nervous system development [GO:0048485]; trochlear nerve formation [GO:0021642]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; dopaminergic neuron differentiation [GO:0071542]; locus ceruleus development [GO:0021703]; midbrain development [GO:0030901]; noradrenergic neuron differentiation [GO:0003357]; oculomotor nerve formation [GO:0021623]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of respiratory gaseous exchange [GO:0043576]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic motor neuron differentiation [GO:0021523]; sympathetic nervous system development [GO:0048485]; trochlear nerve formation [GO:0021642]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
O14815	reviewed	CAN9_HUMAN	Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (New calpain 4) (nCL-4) (Protein CG36)	CAPN9 NCL4	Homo sapiens (Human)	690	FUNCTION: Calcium-regulated non-lysosomal thiol-protease.		digestion [GO:0007586]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; digestion [GO:0007586]; proteolysis [GO:0006508]	
O14817	reviewed	TSN4_HUMAN	Tetraspanin-4 (Tspan-4) (Novel antigen 2) (NAG-2) (Transmembrane 4 superfamily member 7)	TSPAN4 NAG2 TM4SF7	Homo sapiens (Human)	238			protein-containing complex assembly [GO:0065003]	focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	antigen binding [GO:0003823]; integrin binding [GO:0005178]	focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; antigen binding [GO:0003823]; integrin binding [GO:0005178]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
O14818	reviewed	PSA7_HUMAN	Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7)	PSMA7 HSPC	Homo sapiens (Human)	248	FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; identical protein binding [GO:0042802]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
O14827	reviewed	RGRF2_HUMAN	Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2)	RASGRF2 GRF2	Homo sapiens (Human)	1237	FUNCTION: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}.		long-term synaptic potentiation [GO:0060291]; Ras protein signal transduction [GO:0007265]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to endoplasmic reticulum stress [GO:0034976]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; guanyl-nucleotide exchange factor activity [GO:0005085]; long-term synaptic potentiation [GO:0060291]; Ras protein signal transduction [GO:0007265]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). {ECO:0000250}.
O14828	reviewed	SCAM3_HUMAN	Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3)	SCAMP3 C1orf3 PROPIN1	Homo sapiens (Human)	347	FUNCTION: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.		post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]	extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]	ubiquitin protein ligase binding [GO:0031625]	extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]; ubiquitin protein ligase binding [GO:0031625]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
O14829	reviewed	PPE1_HUMAN	Serine/threonine-protein phosphatase with EF-hands 1 (PPEF-1) (EC 3.1.3.16) (Protein phosphatase with EF calcium-binding domain) (PPEF) (Serine/threonine-protein phosphatase 7) (PP7)	PPEF1 PPEF PPP7C	Homo sapiens (Human)	653	FUNCTION: May have a role in the recovery or adaptation response of photoreceptors. May have a role in development.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May have no functional significance. {ECO:0000305}.	detection of stimulus involved in sensory perception [GO:0050906]; protein dephosphorylation [GO:0006470]	cytosol [GO:0005829]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; detection of stimulus involved in sensory perception [GO:0050906]; protein dephosphorylation [GO:0006470]	
O14830	reviewed	PPE2_HUMAN	Serine/threonine-protein phosphatase with EF-hands 2 (PPEF-2) (EC 3.1.3.16)	PPEF2	Homo sapiens (Human)	753	FUNCTION: May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.		detection of stimulus involved in sensory perception [GO:0050906]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; protein dephosphorylation [GO:0006470]; regulation of JUN kinase activity [GO:0043506]; regulation of MAP kinase activity [GO:0043405]; visual perception [GO:0007601]	cytosol [GO:0005829]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	calcium ion binding [GO:0005509]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; calcium ion binding [GO:0005509]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; detection of stimulus involved in sensory perception [GO:0050906]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; protein dephosphorylation [GO:0006470]; regulation of JUN kinase activity [GO:0043506]; regulation of MAP kinase activity [GO:0043405]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Note=Localized to photoreceptors, PPEF-2(L) is at least 2 fold more abundant in rod inner segments than in the outer segments.
O14832	reviewed	PAHX_HUMAN	Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH)	PHYH PAHX	Homo sapiens (Human)	338	FUNCTION: Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (PubMed:9326939, PubMed:10744784, PubMed:12031666, PubMed:12923223). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl- and 4-methyl-branched acyl-CoAs (PubMed:10744784, PubMed:12923223). {ECO:0000269|PubMed:10744784, ECO:0000269|PubMed:12031666, ECO:0000269|PubMed:12923223, ECO:0000269|PubMed:9326939}.		2-oxobutyrate catabolic process [GO:0019606]; 2-oxoglutarate metabolic process [GO:0006103]; fatty acid alpha-oxidation [GO:0001561]; isoprenoid metabolic process [GO:0006720]; methyl-branched fatty acid metabolic process [GO:0097089]	9+0 non-motile cilium [GO:0097731]; cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	carboxylic acid binding [GO:0031406]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; phytanoyl-CoA dioxygenase activity [GO:0048244]	9+0 non-motile cilium [GO:0097731]; cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; carboxylic acid binding [GO:0031406]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; phytanoyl-CoA dioxygenase activity [GO:0048244]; 2-oxobutyrate catabolic process [GO:0019606]; 2-oxoglutarate metabolic process [GO:0006103]; fatty acid alpha-oxidation [GO:0001561]; isoprenoid metabolic process [GO:0006720]; methyl-branched fatty acid metabolic process [GO:0097089]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:9326939}.
O14836	reviewed	TR13B_HUMAN	Tumor necrosis factor receptor superfamily member 13B (Transmembrane activator and CAML interactor) (CD antigen CD267)	TNFRSF13B TACI	Homo sapiens (Human)	293	FUNCTION: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. {ECO:0000269|PubMed:10956646, ECO:0000269|PubMed:10973284}.		adaptive immune response [GO:0002250]; B cell homeostasis [GO:0001782]; cell surface receptor signaling pathway [GO:0007166]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of B cell proliferation [GO:0030889]	plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; adaptive immune response [GO:0002250]; B cell homeostasis [GO:0001782]; cell surface receptor signaling pathway [GO:0007166]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of B cell proliferation [GO:0030889]	SUBCELLULAR LOCATION: Membrane; Single-pass type III membrane protein.
O14841	reviewed	OPLA_HUMAN	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase)	OPLAH	Homo sapiens (Human)	1288	FUNCTION: Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.		glutathione metabolic process [GO:0006749]	cytosol [GO:0005829]	5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; 5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; glutathione metabolic process [GO:0006749]	
O14842	reviewed	FFAR1_HUMAN	Free fatty acid receptor 1 (G-protein coupled receptor 40)	FFAR1 GPR40	Homo sapiens (Human)	300	FUNCTION: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. {ECO:0000250|UniProtKB:Q76JU9, ECO:0000269|PubMed:12496284, ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:23809162, ECO:0000269|PubMed:24130766, ECO:0000269|PubMed:24742677}.		G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of interleukin-1 beta production [GO:0032691]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of insulin secretion [GO:0032024]; response to fatty acid [GO:0070542]	plasma membrane [GO:0005886]	bioactive lipid receptor activity [GO:0045125]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]	plasma membrane [GO:0005886]; bioactive lipid receptor activity [GO:0045125]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of interleukin-1 beta production [GO:0032691]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of insulin secretion [GO:0032024]; response to fatty acid [GO:0070542]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:25043059}; Multi-pass membrane protein {ECO:0000269|PubMed:25043059}.
O14843	reviewed	FFAR3_HUMAN	Free fatty acid receptor 3 (G-protein coupled receptor 41)	FFAR3 GPR41	Homo sapiens (Human)	346	FUNCTION: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed:12496283, PubMed:12711604). {ECO:0000269|PubMed:12496283, ECO:0000269|PubMed:12711604, ECO:0000269|PubMed:18801738, ECO:0000269|PubMed:23066016}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to fatty acid [GO:0071398]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; mucosal immune response [GO:0002385]; negative regulation of blood pressure [GO:0045776]; positive regulation of acute inflammatory response to non-antigenic stimulus [GO:0002879]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in immune response [GO:0002720]; regulation of hormone biosynthetic process [GO:0046885]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of norepinephrine secretion [GO:0014061]; regulation of peptide hormone secretion [GO:0090276]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to fatty acid [GO:0071398]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; mucosal immune response [GO:0002385]; negative regulation of blood pressure [GO:0045776]; positive regulation of acute inflammatory response to non-antigenic stimulus [GO:0002879]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in immune response [GO:0002720]; regulation of hormone biosynthetic process [GO:0046885]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of norepinephrine secretion [GO:0014061]; regulation of peptide hormone secretion [GO:0090276]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18801738}; Multi-pass membrane protein {ECO:0000269|PubMed:18801738}.
O14862	reviewed	AIM2_HUMAN	Interferon-inducible protein AIM2 (Absent in melanoma 2)	AIM2	Homo sapiens (Human)	343	FUNCTION: Sensor component of the AIM2 inflammasome, which mediates inflammasome activation in response to the presence of double-stranded DNA (dsDNA) in the cytosol, leading to subsequent pyroptosis (PubMed:17726700, PubMed:19158675, PubMed:19158676, PubMed:19158679, PubMed:20566831, PubMed:26197926, PubMed:29440442, PubMed:23530044, PubMed:26583071, PubMed:33980849). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:17726700, PubMed:19158675, PubMed:19158676, PubMed:19158679, PubMed:20566831, PubMed:26197926, PubMed:29440442, PubMed:33980849). Acts as a recognition receptor (PRR): specifically recognizes and binds dsDNA in the cytosol, and mediates the formation of the inflammasome polymeric complex composed of AIM2, CASP1 and PYCARD/ASC (PubMed:17726700, PubMed:19158675, PubMed:19158676, PubMed:19158679, PubMed:20566831, PubMed:26197926, PubMed:29440442, PubMed:33980849). Recruitment of pro-caspase-1 (proCASP1) to the AIM2 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion (PubMed:17726700, PubMed:19158675, PubMed:19158676, PubMed:19158679, PubMed:20566831). In some cells, CASP1 activation mediates cleavage and activation of GSDMD, triggering pyroptosis without promoting cytokine secretion (PubMed:19158675, PubMed:19158676). Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner (PubMed:17726700, PubMed:19158675, PubMed:19158676, PubMed:19158679, PubMed:20566831, PubMed:26197926, PubMed:29440442, PubMed:26583071, PubMed:33980849). Involved in the DNA damage response caused by acute ionizing radiation by mediating pyroptosis of intestinal epithelial cells and bone marrow cells in response to double-strand DNA breaks (By similarity). Mechanistically, AIM2 senses DNA damage in the nucleus to mediate inflammasome assembly and inflammatory cell death (By similarity). Also acts as a regulator of neurodevelopment via its role in the DNA damage response: acts by promoting neural cell death in response to DNA damage in the developing brain, thereby purging genetically compromised cells of the central nervous system (By similarity). Pyroptosis mediated by the AIM2 inflammasome in response to DNA damage is dependent on GSDMD without involving IL1B and IL18 cytokine secretion (By similarity). Also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). Can also trigger PYCARD/ASC-dependent, caspase-1-independent cell death that involves caspase-8 (CASP8) (By similarity). {ECO:0000250|UniProtKB:Q91VJ1, ECO:0000269|PubMed:17726700, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679, ECO:0000269|PubMed:20566831, ECO:0000269|PubMed:23530044, ECO:0000269|PubMed:26197926, ECO:0000269|PubMed:26583071, ECO:0000269|PubMed:29440442, ECO:0000269|PubMed:33980849}.; FUNCTION: Also acts as a tumor suppressor independently of its role in inflammatory response (PubMed:16432157). Able to suppress overt cell proliferation in enterocytes: restricts stem cell proliferation in the intestinal mucosa in an inflammasome-independent manner, contributing to a decrease in the likelihood of colorectal cancer development (By similarity). AIM2 suppresses cell proliferation by inhibiting phosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Inhibits AKT1 phosphorylation both by inhibiting the activity of PRKDC/DNA-PK kinase and promoting dephosphorylation by PP2A phosphatase (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) homeostasis by promoting their stability: acts by preventing AKT1 activation (By similarity). Its role in Treg homeostasis is important to restain autoimmune diseases (By similarity). {ECO:0000250|UniProtKB:Q91VJ1, ECO:0000269|PubMed:16432157}.	MISCELLANEOUS: Defects in AIM2 may be a cause of microsatellite unstable colon cancers. {ECO:0000269|PubMed:17726700}.	activation of innate immune response [GO:0002218]; AIM2 inflammasome complex assembly [GO:0140970]; brain development [GO:0007420]; cellular response to interferon-beta [GO:0035458]; cellular response to xenobiotic stimulus [GO:0071466]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; neuron cellular homeostasis [GO:0070050]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; pyroptosis [GO:0070269]; pyroptosome complex assembly [GO:1904270]; regulation of behavior [GO:0050795]; T cell homeostasis [GO:0043029]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	AIM2 inflammasome complex [GO:0097169]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]	cysteine-type endopeptidase activator activity [GO:0140608]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; signaling adaptor activity [GO:0035591]	AIM2 inflammasome complex [GO:0097169]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; cysteine-type endopeptidase activator activity [GO:0140608]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; signaling adaptor activity [GO:0035591]; activation of innate immune response [GO:0002218]; AIM2 inflammasome complex assembly [GO:0140970]; brain development [GO:0007420]; cellular response to interferon-beta [GO:0035458]; cellular response to xenobiotic stimulus [GO:0071466]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; neuron cellular homeostasis [GO:0070050]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; pyroptosis [GO:0070269]; pyroptosome complex assembly [GO:1904270]; regulation of behavior [GO:0050795]; T cell homeostasis [GO:0043029]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679, ECO:0000269|PubMed:24531343, ECO:0000269|PubMed:8454910}. Inflammasome {ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679}. Nucleus {ECO:0000269|PubMed:15582594}. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles (PubMed:19158679, PubMed:19158676, PubMed:19158675). Activated inflammasomes can also aggregate in the nucleus in response to DNA damage: AIM2 is recruited to double-strand DNA breaks and mediates activation of the AIM2 inflammasome (By similarity). {ECO:0000250|UniProtKB:Q91VJ1, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679}.
O14863	reviewed	ZNT4_HUMAN	Probable proton-coupled zinc antiporter SLC30A4 (Solute carrier family 30 member 4) (Zinc transporter 4) (ZnT-4)	SLC30A4 ZNT4	Homo sapiens (Human)	429	FUNCTION: Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment (PubMed:19521526). Controls zinc deposition in milk (By similarity). {ECO:0000250|UniProtKB:O35149, ECO:0000305|PubMed:19521526}.		regulation of sequestering of zinc ion [GO:0061088]; response to toxic substance [GO:0009636]; response to zinc ion [GO:0010043]; zinc export across plasma membrane [GO:0140882]; zinc ion transmembrane transport [GO:0071577]	cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	antiporter activity [GO:0015297]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385]	cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385]; regulation of sequestering of zinc ion [GO:0061088]; response to toxic substance [GO:0009636]; response to zinc ion [GO:0010043]; zinc export across plasma membrane [GO:0140882]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:O55174}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:17349999}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17349999}; Multi-pass membrane protein {ECO:0000255}. Note=Enriched in vesicles within the basal region of epithelial cells. {ECO:0000250|UniProtKB:O55174}.
O14867	reviewed	BACH1_HUMAN	Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303)	BACH1	Homo sapiens (Human)	736	FUNCTION: Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). {ECO:0000250|UniProtKB:P97302, ECO:0000269|PubMed:24035498}.		DNA repair [GO:0006281]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of metabolic process [GO:0019222]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; regulation of transcription involved in G2/M transition of mitotic cell cycle [GO:0000117]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; heme binding [GO:0020037]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; heme binding [GO:0020037]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; DNA repair [GO:0006281]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of metabolic process [GO:0019222]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; regulation of transcription involved in G2/M transition of mitotic cell cycle [GO:0000117]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:24035498}.
O14874	reviewed	BCKD_HUMAN	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (EC 2.7.11.4) (Branched-chain alpha-ketoacid dehydrogenase kinase) (BCKD-kinase) (BCKDHKIN)	BCKDK	Homo sapiens (Human)	412	FUNCTION: Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. {ECO:0000269|PubMed:24449431}.		amino acid catabolic process [GO:0009063]; branched-chain amino acid catabolic process [GO:0009083]; negative regulation of cellular amino acid metabolic process [GO:0045763]; phosphorylation [GO:0016310]; regulation of glucose metabolic process [GO:0010906]	mitochondrial alpha-ketoglutarate dehydrogenase complex [GO:0005947]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity [GO:0047323]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein serine/threonine kinase activity [GO:0004674]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740]	mitochondrial alpha-ketoglutarate dehydrogenase complex [GO:0005947]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity [GO:0047323]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein serine/threonine kinase activity [GO:0004674]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740]; amino acid catabolic process [GO:0009063]; branched-chain amino acid catabolic process [GO:0009083]; negative regulation of cellular amino acid metabolic process [GO:0045763]; phosphorylation [GO:0016310]; regulation of glucose metabolic process [GO:0010906]	SUBCELLULAR LOCATION: Mitochondrion matrix. Mitochondrion {ECO:0000269|PubMed:24449431}.
O14879	reviewed	IFIT3_HUMAN	Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G)	IFIT3 CIG-49 IFI60 IFIT4 ISG60	Homo sapiens (Human)	490	FUNCTION: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20686046, ECO:0000269|PubMed:21190939, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21813773}.		antiviral innate immune response [GO:0140374]; defense response to virus [GO:0051607]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; identical protein binding [GO:0042802]; antiviral innate immune response [GO:0140374]; defense response to virus [GO:0051607]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:18706081}. Mitochondrion {ECO:0000269|PubMed:21813773}.
O14880	reviewed	MGST3_HUMAN	Glutathione S-transferase 3, mitochondrial (GST-3) (EC 2.5.1.-) (Glutathione peroxidase MGST3) (EC 1.11.1.-) (LTC4 synthase MGST3) (EC 4.4.1.20)	MGST3	Homo sapiens (Human)	152	FUNCTION: Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids, as part of cellular detoxification as well as synthesis of bioactive metabolites (PubMed:9278457, PubMed:36370807). Catalyzes conjugate addition of reduced glutathione to the alpha, beta-unsaturated C=C carbonyl group of eisosanoids such as leukotriene A4 and 15-deoxy-Delta12,14-prostaglandin J2 to form GSH adducts relevant to the inflammatory response (PubMed:9278457, PubMed:36370807). Catalyzes glutathione-dependent reduction of eicosanoid peroxides to yield the corresponding eicosanoid hydroxides (PubMed:9278457). {ECO:0000269|PubMed:36370807, ECO:0000269|PubMed:9278457}.		arachidonic acid metabolic process [GO:0019369]; leukotriene biosynthetic process [GO:0019370]; lipid metabolic process [GO:0006629]; prostanoid metabolic process [GO:0006692]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]	glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464]; arachidonic acid metabolic process [GO:0019369]; leukotriene biosynthetic process [GO:0019370]; lipid metabolic process [GO:0006629]; prostanoid metabolic process [GO:0006692]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:27184847}; Multi-pass membrane protein {ECO:0000255}.
O14893	reviewed	GEMI2_HUMAN	Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1)	GEMIN2 SIP1	Homo sapiens (Human)	280	FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9323129). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (PubMed:18984161, PubMed:9323129). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (PubMed:31799625, PubMed:21816274, PubMed:16314521). {ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9323129}.		mRNA processing [GO:0006397]; negative regulation of RNA binding [GO:1905215]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]	cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]		cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; mRNA processing [GO:0006397]; negative regulation of RNA binding [GO:1905215]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.
O14894	reviewed	T4S5_HUMAN	Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H)	TM4SF5	Homo sapiens (Human)	197	FUNCTION: Acts as a lysosomal membrane arginine sensor (PubMed:30956113). Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations (PubMed:30956113). Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus (PubMed:20399237). CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression (PubMed:20399237). {ECO:0000269|PubMed:20399237, ECO:0000269|PubMed:30956113}.		cell cycle [GO:0007049]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]	lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	arginine binding [GO:0034618]	lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; arginine binding [GO:0034618]; cell cycle [GO:0007049]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:30956113}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30956113}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to cell membrane increases during conditions of arginine depletion and translocation to lysosome membrane seen upon arginine repletion. {ECO:0000269|PubMed:30956113}.
O14896	reviewed	IRF6_HUMAN	Interferon regulatory factor 6 (IRF-6)	IRF6	Homo sapiens (Human)	467	FUNCTION: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). {ECO:0000250}.		cell development [GO:0048468]; cranial skeletal system development [GO:1904888]; immune system process [GO:0002376]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; limb development [GO:0060173]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of stem cell proliferation [GO:2000647]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; stem cell proliferation [GO:0072089]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; cell development [GO:0048468]; cranial skeletal system development [GO:1904888]; immune system process [GO:0002376]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; limb development [GO:0060173]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of stem cell proliferation [GO:2000647]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16049006, ECO:0000269|PubMed:18212048}. Note=Translocates to nucleus in response to an activating signal. {ECO:0000250}.
O14901	reviewed	KLF11_HUMAN	Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2)	KLF11 FKLF TIEG2	Homo sapiens (Human)	512	FUNCTION: Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8K1S5, ECO:0000269|PubMed:10207080, ECO:0000269|PubMed:16131492}.		apoptotic process [GO:0006915]; cellular response to peptide [GO:1901653]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	chromatin [GO:0000785]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; apoptotic process [GO:0006915]; cellular response to peptide [GO:1901653]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9748269}.
O14904	reviewed	WNT9A_HUMAN	Protein Wnt-9a (Protein Wnt-14)	WNT9A WNT14	Homo sapiens (Human)	365	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity. {ECO:0000250|UniProtKB:O42280, ECO:0000250|UniProtKB:Q8R5M2}.		canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; cornea development in camera-type eye [GO:0061303]; embryonic skeletal joint development [GO:0072498]; iris morphogenesis [GO:0061072]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; neuron differentiation [GO:0030182]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; cornea development in camera-type eye [GO:0061303]; embryonic skeletal joint development [GO:0072498]; iris morphogenesis [GO:0061072]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; neuron differentiation [GO:0030182]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
O14905	reviewed	WNT9B_HUMAN	Protein Wnt-9b (Protein Wnt-14b) (Protein Wnt-15)	WNT9B WNT14B WNT15 UNQ6973/PRO21956	Homo sapiens (Human)	357	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity). {ECO:0000250|UniProtKB:O35468, ECO:0000305|PubMed:20093360}.		branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; cellular response to starvation [GO:0009267]; collecting duct development [GO:0072044]; cornea development in camera-type eye [GO:0061303]; embryonic cranial skeleton morphogenesis [GO:0048701]; establishment of planar polarity involved in nephron morphogenesis [GO:0072046]; in utero embryonic development [GO:0001701]; kidney rudiment formation [GO:0072003]; male genitalia development [GO:0030539]; mesenchymal stem cell maintenance involved in nephron morphogenesis [GO:0072038]; mesonephric duct formation [GO:0072181]; metanephric tubule formation [GO:0072174]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of stem cell population maintenance [GO:1902455]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1905438]; regulation of asymmetric cell division [GO:0009786]; regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003339]; regulation of protein phosphorylation [GO:0001932]; regulation of tube size [GO:0035150]; response to retinoic acid [GO:0032526]; roof of mouth development [GO:0060021]; uterus morphogenesis [GO:0061038]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; cellular response to starvation [GO:0009267]; collecting duct development [GO:0072044]; cornea development in camera-type eye [GO:0061303]; embryonic cranial skeleton morphogenesis [GO:0048701]; establishment of planar polarity involved in nephron morphogenesis [GO:0072046]; in utero embryonic development [GO:0001701]; kidney rudiment formation [GO:0072003]; male genitalia development [GO:0030539]; mesenchymal stem cell maintenance involved in nephron morphogenesis [GO:0072038]; mesonephric duct formation [GO:0072181]; metanephric tubule formation [GO:0072174]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of stem cell population maintenance [GO:1902455]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1905438]; regulation of asymmetric cell division [GO:0009786]; regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003339]; regulation of protein phosphorylation [GO:0001932]; regulation of tube size [GO:0035150]; response to retinoic acid [GO:0032526]; roof of mouth development [GO:0060021]; uterus morphogenesis [GO:0061038]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
O14907	reviewed	TX1B3_HUMAN	Tax1-binding protein 3 (Glutaminase-interacting protein 3) (Tax interaction protein 1) (TIP-1) (Tax-interacting protein 1)	TAX1BP3 TIP1	Homo sapiens (Human)	124	FUNCTION: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:16855024, ECO:0000269|PubMed:21139582}.		activation of GTPase activity [GO:0090630]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of Wnt signaling pathway [GO:0030178]; proteolysis [GO:0006508]; Rho protein signal transduction [GO:0007266]; Wnt signaling pathway [GO:0016055]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	beta-catenin binding [GO:0008013]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; activation of GTPase activity [GO:0090630]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of Wnt signaling pathway [GO:0030178]; proteolysis [GO:0006508]; Rho protein signal transduction [GO:0007266]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cell membrane by interaction with membrane proteins.
O14908	reviewed	GIPC1_HUMAN	PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2)	GIPC1 C19orf3 GIPC RGS19IP1	Homo sapiens (Human)	333	FUNCTION: May be involved in G protein-linked signaling.		cellular response to interleukin-7 [GO:0098761]; chemical synaptic transmission [GO:0007268]; endothelial cell migration [GO:0043542]; G protein-coupled receptor signaling pathway [GO:0007186]; glutamate secretion [GO:0014047]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of cytokinesis [GO:0032467]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein targeting [GO:0006605]; regulation of protein stability [GO:0031647]; regulation of synaptic plasticity [GO:0048167]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; vesicle membrane [GO:0012506]	actin binding [GO:0003779]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; vesicle membrane [GO:0012506]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102]; cellular response to interleukin-7 [GO:0098761]; chemical synaptic transmission [GO:0007268]; endothelial cell migration [GO:0043542]; G protein-coupled receptor signaling pathway [GO:0007186]; glutamate secretion [GO:0014047]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of cytokinesis [GO:0032467]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein targeting [GO:0006605]; regulation of protein stability [GO:0031647]; regulation of synaptic plasticity [GO:0048167]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32413282, ECO:0000269|PubMed:9770488}. Membrane {ECO:0000269|PubMed:9770488}; Peripheral membrane protein.
O14910	reviewed	LIN7A_HUMAN	Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1)	LIN7A MALS1 VELI1	Homo sapiens (Human)	233	FUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}.		exocytosis [GO:0006887]; inner ear development [GO:0048839]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neurotransmitter secretion [GO:0007269]; protein localization to basolateral plasma membrane [GO:1903361]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; synaptic vesicle transport [GO:0048489]	basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; MPP7-DLG1-LIN7 complex [GO:0097025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; synapse [GO:0045202]	L27 domain binding [GO:0097016]	basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; MPP7-DLG1-LIN7 complex [GO:0097025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; synapse [GO:0045202]; L27 domain binding [GO:0097016]; exocytosis [GO:0006887]; inner ear development [GO:0048839]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neurotransmitter secretion [GO:0007269]; protein localization to basolateral plasma membrane [GO:1903361]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; synaptic vesicle transport [GO:0048489]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8JZS0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8JZS0}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8JZS0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8JZS0}. Cell junction {ECO:0000250|UniProtKB:Q8JZS0}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q8JZS0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8JZS0}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q8JZS0}. Note=Mainly basolateral in renal epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0}.
O14917	reviewed	PCD17_HUMAN	Protocadherin-17 (Protocadherin-68)	PCDH17 PCDH68 PCH68	Homo sapiens (Human)	1159	FUNCTION: Potential calcium-dependent cell-adhesion protein.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	adult behavior [GO:0030534]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of synaptic transmission [GO:0050805]; presynaptic active zone assembly [GO:1904071]; regulation of synaptic vesicle clustering [GO:2000807]; synaptic membrane adhesion [GO:0099560]	GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	calcium ion binding [GO:0005509]	GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; calcium ion binding [GO:0005509]; adult behavior [GO:0030534]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of synaptic transmission [GO:0050805]; presynaptic active zone assembly [GO:1904071]; regulation of synaptic vesicle clustering [GO:2000807]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
O14920	reviewed	IKKB_HUMAN	Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)	IKBKB IKKB	Homo sapiens (Human)	756	FUNCTION: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484, PubMed:30337470). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:9346484, PubMed:20434986, PubMed:20797629, PubMed:21138416). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:9346484, PubMed:20434986, PubMed:20797629, PubMed:21138416). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:9346484, PubMed:20434986, PubMed:20797629, PubMed:21138416). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:19716809, PubMed:17213322). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:9346484}.		antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to tumor necrosis factor [GO:0071356]; cortical actin cytoskeleton organization [GO:0030866]; Fc-epsilon receptor signaling pathway [GO:0038095]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; protein phosphorylation [GO:0006468]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of phosphorylation [GO:0042325]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to virus [GO:0009615]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 3 signaling pathway [GO:0034138]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; membrane raft [GO:0045121]; nucleus [GO:0005634]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; IkappaB kinase activity [GO:0008384]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; scaffold protein binding [GO:0097110]; transferrin receptor binding [GO:1990459]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; membrane raft [GO:0045121]; nucleus [GO:0005634]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; IkappaB kinase activity [GO:0008384]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; scaffold protein binding [GO:0097110]; transferrin receptor binding [GO:1990459]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to tumor necrosis factor [GO:0071356]; cortical actin cytoskeleton organization [GO:0030866]; Fc-epsilon receptor signaling pathway [GO:0038095]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; protein phosphorylation [GO:0006468]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of phosphorylation [GO:0042325]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to virus [GO:0009615]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 3 signaling pathway [GO:0034138]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20797629}. Nucleus {ECO:0000269|PubMed:20797629}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:17287217}.
O14924	reviewed	RGS12_HUMAN	Regulator of G-protein signaling 12 (RGS12)	RGS12	Homo sapiens (Human)	1447	FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. {ECO:0000250|UniProtKB:O08774}.; FUNCTION: [Isoform 5]: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. {ECO:0000269|PubMed:12024043}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; GTPase regulator activity [GO:0030695]	condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; GTPase regulator activity [GO:0030695]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10869340}. Cytoplasm {ECO:0000250|UniProtKB:O08774}. Cell projection, dendrite {ECO:0000250|UniProtKB:O08774}. Synapse {ECO:0000250|UniProtKB:O08774}.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus matrix {ECO:0000269|PubMed:12024043}. Note=Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains. {ECO:0000269|PubMed:12024043}.
O14925	reviewed	TIM23_HUMAN	Mitochondrial import inner membrane translocase subunit Tim23	TIMM23 TIM23	Homo sapiens (Human)	209	FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. {ECO:0000305|PubMed:10339406}.		intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	protein transmembrane transporter activity [GO:0008320]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; protein transmembrane transporter activity [GO:0008320]; intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:25997101}; Multi-pass membrane protein {ECO:0000255}.
O14926	reviewed	FSCN2_HUMAN	Fascin-2 (Retinal fascin)	FSCN2	Homo sapiens (Human)	492	FUNCTION: Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.		actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; anatomical structure morphogenesis [GO:0009653]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; eye photoreceptor cell development [GO:0042462]; visual perception [GO:0007601]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; stereocilium [GO:0032420]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; protein-macromolecule adaptor activity [GO:0030674]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; stereocilium [GO:0032420]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; protein-macromolecule adaptor activity [GO:0030674]; actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; anatomical structure morphogenesis [GO:0009653]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; eye photoreceptor cell development [GO:0042462]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}.
O14929	reviewed	HAT1_HUMAN	Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1)	HAT1 KAT1	Homo sapiens (Human)	419	FUNCTION: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:31278053, PubMed:20953179, PubMed:23653357, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:22615379, PubMed:11585814). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Acetylates also RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350). {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:23653357, ECO:0000269|PubMed:31278053, ECO:0000269|PubMed:31812350, ECO:0000269|PubMed:32081014}.; FUNCTION: (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell. {ECO:0000269|PubMed:31695772}.		chromosome organization [GO:0051276]; internal protein amino acid acetylation [GO:0006475]; nucleosome assembly [GO:0006334]; subtelomeric heterochromatin formation [GO:0031509]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; chromosome organization [GO:0051276]; internal protein amino acid acetylation [GO:0006475]; nucleosome assembly [GO:0006334]; subtelomeric heterochromatin formation [GO:0031509]	SUBCELLULAR LOCATION: [Isoform A]: Nucleus matrix {ECO:0000269|PubMed:20148353, ECO:0000269|PubMed:23653357}. Mitochondrion {ECO:0000269|PubMed:32081014}.; SUBCELLULAR LOCATION: [Isoform B]: Cytoplasm {ECO:0000269|PubMed:20148353}. Nucleus {ECO:0000269|PubMed:20148353}. Nucleus matrix {ECO:0000269|PubMed:20148353}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20148353}. Note=Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein. {ECO:0000269|PubMed:20148353}.
O14931	reviewed	NCTR3_HUMAN	Natural cytotoxicity triggering receptor 3 (Activating natural killer receptor p30) (Natural killer cell p30-related protein) (NK-p30) (NKp30) (CD antigen CD337)	NCR3 1C7 LY117	Homo sapiens (Human)	201	FUNCTION: Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. {ECO:0000269|PubMed:10562324, ECO:0000269|PubMed:15784725, ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.		cell recognition [GO:0008037]; immune response [GO:0006955]; immune response-activating cell surface receptor signaling pathway [GO:0002429]; inflammatory response [GO:0006954]; natural killer cell activation [GO:0030101]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]	plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; cell recognition [GO:0008037]; immune response [GO:0006955]; immune response-activating cell surface receptor signaling pathway [GO:0002429]; inflammatory response [GO:0006954]; natural killer cell activation [GO:0030101]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10562324}; Single-pass type I membrane protein {ECO:0000255}.
O14933	reviewed	UB2L6_HUMAN	Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)	UBE2L6 UBCH8	Homo sapiens (Human)	153	FUNCTION: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. {ECO:0000269|PubMed:15131269, ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:20508617}.		innate immune response [GO:0045087]; ISG15-protein conjugation [GO:0032020]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	ISG15 transferase activity [GO:0042296]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; ISG15 transferase activity [GO:0042296]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; innate immune response [GO:0045087]; ISG15-protein conjugation [GO:0032020]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	
O14936	reviewed	CSKP_HUMAN	Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)	CASK LIN2	Homo sapiens (Human)	926	FUNCTION: Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O70589, ECO:0000269|PubMed:18423203}.		calcium ion import [GO:0070509]; cell adhesion [GO:0007155]; establishment of localization in cell [GO:0051649]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of wound healing [GO:0061045]; phosphorylation [GO:0016310]; positive regulation of calcium ion import [GO:0090280]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle exocytosis [GO:2000300]	actin cytoskeleton [GO:0015629]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; vesicle [GO:0031982]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; guanylate kinase activity [GO:0004385]; neurexin family protein binding [GO:0042043]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor binding [GO:0005102]	actin cytoskeleton [GO:0015629]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; vesicle [GO:0031982]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; guanylate kinase activity [GO:0004385]; neurexin family protein binding [GO:0042043]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor binding [GO:0005102]; calcium ion import [GO:0070509]; cell adhesion [GO:0007155]; establishment of localization in cell [GO:0051649]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of wound healing [GO:0061045]; phosphorylation [GO:0016310]; positive regulation of calcium ion import [GO:0090280]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle exocytosis [GO:2000300]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q62915}. Cytoplasm {ECO:0000250|UniProtKB:Q62915}. Cell membrane {ECO:0000250|UniProtKB:Q62915}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62915}.
O14939	reviewed	PLD2_HUMAN	Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2)	PLD2	Homo sapiens (Human)	933	FUNCTION: Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). {ECO:0000250|UniProtKB:P97813, ECO:0000269|PubMed:9582313}.		cytoskeleton organization [GO:0007010]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid catabolic process [GO:0009395]; regulation of vesicle-mediated transport [GO:0060627]; small GTPase mediated signal transduction [GO:0007264]; synaptic vesicle recycling [GO:0036465]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; phosphatidylinositol binding [GO:0035091]; phospholipase D activity [GO:0004630]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; phosphatidylinositol binding [GO:0035091]; phospholipase D activity [GO:0004630]; cytoskeleton organization [GO:0007010]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid catabolic process [GO:0009395]; regulation of vesicle-mediated transport [GO:0060627]; small GTPase mediated signal transduction [GO:0007264]; synaptic vesicle recycling [GO:0036465]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P97813}; Lipid-anchor {ECO:0000250|UniProtKB:P97813}.
O14944	reviewed	EREG_HUMAN	Proepiregulin [Cleaved into: Epiregulin (EPR)]	EREG	Homo sapiens (Human)	169	FUNCTION: Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). {ECO:0000269|PubMed:9419975, ECO:0000303|PubMed:24631357}.		anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cell-cell signaling [GO:0007267]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB4 signaling pathway [GO:0038135]; ERBB4-ERBB4 signaling pathway [GO:0038138]; female meiotic nuclear division [GO:0007143]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; luteinizing hormone signaling pathway [GO:0042700]; mRNA transcription [GO:0009299]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of smooth muscle cell differentiation [GO:0051151]; oocyte maturation [GO:0001556]; ovarian cumulus expansion [GO:0001550]; ovulation [GO:0030728]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA replication [GO:0045740]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of smooth muscle cell proliferation [GO:0048661]; primary follicle stage [GO:0048160]; response to peptide hormone [GO:0043434]; wound healing [GO:0042060]	clathrin-coated endocytic vesicle membrane [GO:0030669]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	clathrin-coated endocytic vesicle membrane [GO:0030669]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cell-cell signaling [GO:0007267]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB4 signaling pathway [GO:0038135]; ERBB4-ERBB4 signaling pathway [GO:0038138]; female meiotic nuclear division [GO:0007143]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; luteinizing hormone signaling pathway [GO:0042700]; mRNA transcription [GO:0009299]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of smooth muscle cell differentiation [GO:0051151]; oocyte maturation [GO:0001556]; ovarian cumulus expansion [GO:0001550]; ovulation [GO:0030728]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA replication [GO:0045740]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of smooth muscle cell proliferation [GO:0048661]; primary follicle stage [GO:0048160]; response to peptide hormone [GO:0043434]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: [Epiregulin]: Secreted, extracellular space {ECO:0000269|PubMed:9337852}.; SUBCELLULAR LOCATION: [Proepiregulin]: Cell membrane {ECO:0000269|PubMed:9337852}; Single-pass type I membrane protein {ECO:0000269|PubMed:9337852}.
O14948	reviewed	TFEC_HUMAN	Transcription factor EC (TFE-C) (Class E basic helix-loop-helix protein 34) (bHLHe34) (Transcription factor EC-like) (hTFEC-L)	TFEC BHLHE34 TCFEC TFECL	Homo sapiens (Human)	347	FUNCTION: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. {ECO:0000250, ECO:0000269|PubMed:11467950, ECO:0000269|PubMed:9256061}.		cellular response to heat [GO:0034605]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to heat [GO:0034605]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11467950}.
O14949	reviewed	QCR8_HUMAN	Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C)	UQCRQ	Homo sapiens (Human)	82	FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000250|UniProtKB:P08525}.		cellular respiration [GO:0045333]; cerebellar Purkinje cell layer development [GO:0021680]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; midbrain development [GO:0030901]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; pons development [GO:0021548]; pyramidal neuron development [GO:0021860]; subthalamus development [GO:0021539]; thalamus development [GO:0021794]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]; cellular respiration [GO:0045333]; cerebellar Purkinje cell layer development [GO:0021680]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; midbrain development [GO:0030901]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; pons development [GO:0021548]; pyramidal neuron development [GO:0021860]; subthalamus development [GO:0021539]; thalamus development [GO:0021794]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P08525}; Single-pass membrane protein {ECO:0000250|UniProtKB:P08525}.
O14950	reviewed	ML12B_HUMAN	Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)	MYL12B MRLC2 MYLC2B	Homo sapiens (Human)	172	FUNCTION: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. {ECO:0000269|PubMed:10965042}.	MISCELLANEOUS: This chain binds calcium. {ECO:0000250}.	regulation of cell shape [GO:0008360]	apical part of cell [GO:0045177]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myofibril [GO:0030016]; myosin II complex [GO:0016460]; stress fiber [GO:0001725]; Z disc [GO:0030018]	calcium ion binding [GO:0005509]; myosin heavy chain binding [GO:0032036]	apical part of cell [GO:0045177]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myofibril [GO:0030016]; myosin II complex [GO:0016460]; stress fiber [GO:0001725]; Z disc [GO:0030018]; calcium ion binding [GO:0005509]; myosin heavy chain binding [GO:0032036]; regulation of cell shape [GO:0008360]	
O14958	reviewed	CASQ2_HUMAN	Calsequestrin-2 (Calsequestrin, cardiac muscle isoform)	CASQ2	Homo sapiens (Human)	399	FUNCTION: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000269|PubMed:16908766, ECO:0000269|PubMed:17881003, ECO:0000269|PubMed:18399795, ECO:0000269|PubMed:21416293}.		cardiac muscle contraction [GO:0060048]; cellular response to caffeine [GO:0071313]; detection of calcium ion [GO:0005513]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; protein polymerization [GO:0051258]; Purkinje myocyte to ventricular cardiac muscle cell signaling [GO:0086029]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of heart rate [GO:0002027]; regulation of membrane repolarization [GO:0060306]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; sequestering of calcium ion [GO:0051208]; striated muscle contraction [GO:0006941]	calcium channel complex [GO:0034704]; cytoplasm [GO:0005737]; junctional sarcoplasmic reticulum membrane [GO:0014701]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018]	calcium ion binding [GO:0005509]; calcium ion sequestering activity [GO:0140314]; calcium-dependent protein binding [GO:0048306]; ion binding [GO:0043167]; protein homodimerization activity [GO:0042803]	calcium channel complex [GO:0034704]; cytoplasm [GO:0005737]; junctional sarcoplasmic reticulum membrane [GO:0014701]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018]; calcium ion binding [GO:0005509]; calcium ion sequestering activity [GO:0140314]; calcium-dependent protein binding [GO:0048306]; ion binding [GO:0043167]; protein homodimerization activity [GO:0042803]; cardiac muscle contraction [GO:0060048]; cellular response to caffeine [GO:0071313]; detection of calcium ion [GO:0005513]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; protein polymerization [GO:0051258]; Purkinje myocyte to ventricular cardiac muscle cell signaling [GO:0086029]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of heart rate [GO:0002027]; regulation of membrane repolarization [GO:0060306]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; sequestering of calcium ion [GO:0051208]; striated muscle contraction [GO:0006941]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:O09161}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells. {ECO:0000250|UniProtKB:O09161}.
O14960	reviewed	LECT2_HUMAN	Leukocyte cell-derived chemotaxin-2 (LECT-2) (hLECT2)	LECT2	Homo sapiens (Human)	151	FUNCTION: Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921). {ECO:0000269|PubMed:27334921, ECO:0000269|PubMed:9524238}.		chemotaxis [GO:0006935]; skeletal system development [GO:0001501]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; chemotaxis [GO:0006935]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8877413}. Secreted {ECO:0000269|PubMed:8877413}.
O14964	reviewed	HGS_HUMAN	Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)	HGS HRS	Homo sapiens (Human)	777	FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.	MISCELLANEOUS: [Isoform 2]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.	endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; membrane invagination [GO:0010324]; multivesicular body assembly [GO:0036258]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; protein localization to membrane [GO:0072657]; protein targeting to lysosome [GO:0006622]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; receptor internalization [GO:0031623]; regulation of MAP kinase activity [GO:0043405]; regulation of protein catabolic process [GO:0042176]; signal transduction [GO:0007165]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; ESCRT-0 complex [GO:0033565]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; multivesicular body membrane [GO:0032585]; phagocytic vesicle lumen [GO:0097013]	metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; ubiquitin binding [GO:0043130]; ubiquitin-like protein ligase binding [GO:0044389]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; ESCRT-0 complex [GO:0033565]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; multivesicular body membrane [GO:0032585]; phagocytic vesicle lumen [GO:0097013]; metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; ubiquitin binding [GO:0043130]; ubiquitin-like protein ligase binding [GO:0044389]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; membrane invagination [GO:0010324]; multivesicular body assembly [GO:0036258]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; protein localization to membrane [GO:0072657]; protein targeting to lysosome [GO:0006622]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; receptor internalization [GO:0031623]; regulation of MAP kinase activity [GO:0043405]; regulation of protein catabolic process [GO:0042176]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9JJ50}. Early endosome membrane {ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q9JJ50}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ50}. Note=Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments. {ECO:0000269|PubMed:16159959}.
O14965	reviewed	AURKA_HUMAN	Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	Homo sapiens (Human)	403	FUNCTION: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606, PubMed:12390251, PubMed:18615013, PubMed:11039908, PubMed:17125279, PubMed:17360485). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606, PubMed:14523000). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:18056443, PubMed:15128871, PubMed:14702041, PubMed:11551964, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18615013). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}.	MISCELLANEOUS: Centrosome amplification can occur when the cycles are uncoupled, and this amplification is associated with cancer and with an increase in the levels of chromosomal instability.	anterior/posterior axis specification [GO:0009948]; apoptotic process [GO:0006915]; cell division [GO:0051301]; centrosome localization [GO:0051642]; cilium disassembly [GO:0061523]; G2/M transition of mitotic cell cycle [GO:0000086]; liver regeneration [GO:0097421]; mitotic cell cycle [GO:0000278]; mitotic centrosome separation [GO:0007100]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of protein binding [GO:0032091]; neuron projection extension [GO:1990138]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of oocyte maturation [GO:1900195]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein localization to centrosome [GO:0071539]; protein phosphorylation [GO:0006468]; regulation of centrosome cycle [GO:0046605]; regulation of cytokinesis [GO:0032465]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to wounding [GO:0009611]; spindle assembly involved in female meiosis I [GO:0007057]; spindle organization [GO:0007051]	axon hillock [GO:0043203]; basolateral plasma membrane [GO:0016323]; centriole [GO:0005814]; centrosome [GO:0005813]; chromosome passenger complex [GO:0032133]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; germinal vesicle [GO:0042585]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; meiotic spindle [GO:0072687]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; pronucleus [GO:0045120]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole centrosome [GO:0031616]	ATP binding [GO:0005524]; histone H3S10 kinase activity [GO:0035175]; molecular function activator activity [GO:0140677]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ubiquitin protein ligase binding [GO:0031625]	axon hillock [GO:0043203]; basolateral plasma membrane [GO:0016323]; centriole [GO:0005814]; centrosome [GO:0005813]; chromosome passenger complex [GO:0032133]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; germinal vesicle [GO:0042585]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; meiotic spindle [GO:0072687]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; pronucleus [GO:0045120]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole centrosome [GO:0031616]; ATP binding [GO:0005524]; histone H3S10 kinase activity [GO:0035175]; molecular function activator activity [GO:0140677]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ubiquitin protein ligase binding [GO:0031625]; anterior/posterior axis specification [GO:0009948]; apoptotic process [GO:0006915]; cell division [GO:0051301]; centrosome localization [GO:0051642]; cilium disassembly [GO:0061523]; G2/M transition of mitotic cell cycle [GO:0000086]; liver regeneration [GO:0097421]; mitotic cell cycle [GO:0000278]; mitotic centrosome separation [GO:0007100]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of protein binding [GO:0032091]; neuron projection extension [GO:1990138]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of oocyte maturation [GO:1900195]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein localization to centrosome [GO:0071539]; protein phosphorylation [GO:0006468]; regulation of centrosome cycle [GO:0046605]; regulation of cytokinesis [GO:0032465]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to wounding [GO:0009611]; spindle assembly involved in female meiosis I [GO:0007057]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12576638, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:17229885, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:19357306, ECO:0000269|PubMed:21225229, ECO:0000269|PubMed:22014574, ECO:0000269|PubMed:23213400, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:9153231}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:12576638, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:9153231, ECO:0000269|PubMed:9606188}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:P97477}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P97477}. Cell projection, cilium {ECO:0000269|PubMed:17604723}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17604723}. Basolateral cell membrane {ECO:0000250|UniProtKB:F1PNY0}. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). The localization to the spindle poles is regulated by AAAS (PubMed:26246606). {ECO:0000250|UniProtKB:P97477, ECO:0000269|PubMed:17229885, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:21225229, ECO:0000269|PubMed:22014574, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:9606188}.
O14966	reviewed	RAB7L_HUMAN	Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29)	RAB29 RAB7L1	Homo sapiens (Human)	203	FUNCTION: The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection (PubMed:22042847). {ECO:0000250|UniProtKB:Q63481, ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815}.		cell differentiation [GO:0030154]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; melanosome organization [GO:0032438]; mitochondrion organization [GO:0007005]; modulation by host of viral process [GO:0044788]; negative regulation of neuron projection development [GO:0010977]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of receptor recycling [GO:0001921]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein localization to ciliary membrane [GO:1903441]; protein localization to membrane [GO:0072657]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; response to bacterium [GO:0009617]; retrograde transport, endosome to Golgi [GO:0042147]; synapse assembly [GO:0007416]; T cell activation [GO:0042110]; toxin transport [GO:1901998]	cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; melanosome [GO:0042470]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773]	dynein complex binding [GO:0070840]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267]	cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; melanosome [GO:0042470]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773]; dynein complex binding [GO:0070840]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267]; cell differentiation [GO:0030154]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; melanosome organization [GO:0032438]; mitochondrion organization [GO:0007005]; modulation by host of viral process [GO:0044788]; negative regulation of neuron projection development [GO:0010977]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of receptor recycling [GO:0001921]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein localization to ciliary membrane [GO:1903441]; protein localization to membrane [GO:0072657]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; response to bacterium [GO:0009617]; retrograde transport, endosome to Golgi [GO:0042147]; synapse assembly [GO:0007416]; T cell activation [GO:0042110]; toxin transport [GO:1901998]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:24788816}. Golgi apparatus {ECO:0000269|PubMed:22042847}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815}. Vacuole {ECO:0000269|PubMed:22042847}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22042847}. Note=Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (PubMed:29212815). Colocalizes with GM130 at the Golgi apparatus (PubMed:22042847). Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (PubMed:22042847). Colocalizes with TGN46 at the trans-Golgi network (TGN) (PubMed:24788816). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery (PubMed:22042847). {ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815}.
O14967	reviewed	CLGN_HUMAN	Calmegin	CLGN	Homo sapiens (Human)	610	FUNCTION: Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity). {ECO:0000250}.		binding of sperm to zona pellucida [GO:0007339]; protein folding [GO:0006457]; protein-containing complex assembly [GO:0065003]; single fertilization [GO:0007338]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	calcium ion binding [GO:0005509]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; calcium ion binding [GO:0005509]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]; binding of sperm to zona pellucida [GO:0007339]; protein folding [GO:0006457]; protein-containing complex assembly [GO:0065003]; single fertilization [GO:0007338]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
O14972	reviewed	VP26C_HUMAN	Vacuolar protein sorting-associated protein 26C (Down syndrome critical region protein 3) (Down syndrome critical region protein A)	VPS26C DCRA DSCR3 DSCRA	Homo sapiens (Human)	297	FUNCTION: Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). {ECO:0000269|PubMed:28892079}.; FUNCTION: (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}.		endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]	endosome [GO:0005768]; nucleus [GO:0005634]		endosome [GO:0005768]; nucleus [GO:0005634]; endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Endosome {ECO:0000305|PubMed:28892079}.
O14974	reviewed	MYPT1_HUMAN	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)	PPP1R12A MBS MYPT1	Homo sapiens (Human)	1030	FUNCTION: Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.		cellular response to xenobiotic stimulus [GO:0071466]; centrosome cycle [GO:0007098]; mitotic cell cycle [GO:0000278]; negative regulation of catalytic activity [GO:0043086]; positive regulation of myosin-light-chain-phosphatase activity [GO:0035508]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of myosin-light-chain-phosphatase activity [GO:0035507]; regulation of nucleocytoplasmic transport [GO:0046822]; signal transduction [GO:0007165]	A band [GO:0031672]; actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; contractile fiber [GO:0043292]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; PTW/PP1 phosphatase complex [GO:0072357]; Z disc [GO:0030018]	14-3-3 protein binding [GO:0071889]; enzyme inhibitor activity [GO:0004857]; phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901]	A band [GO:0031672]; actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; contractile fiber [GO:0043292]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; PTW/PP1 phosphatase complex [GO:0072357]; Z disc [GO:0030018]; 14-3-3 protein binding [GO:0071889]; enzyme inhibitor activity [GO:0004857]; phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901]; cellular response to xenobiotic stimulus [GO:0071466]; centrosome cycle [GO:0007098]; mitotic cell cycle [GO:0000278]; negative regulation of catalytic activity [GO:0043086]; positive regulation of myosin-light-chain-phosphatase activity [GO:0035508]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of myosin-light-chain-phosphatase activity [GO:0035507]; regulation of nucleocytoplasmic transport [GO:0046822]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12923170, ECO:0000269|PubMed:18477460}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:12923170}. Note=Also along actomyosin filaments. {ECO:0000269|PubMed:12923170}.
O14975	reviewed	S27A2_HUMAN	Long-chain fatty acid transport protein 2 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Phytanate--CoA ligase) (EC 6.2.1.24) (Solute carrier family 27 member 2) (THCA-CoA ligase) (EC 6.2.1.7) (Very long-chain acyl-CoA synthetase) (VLACS) (VLCS) (EC 6.2.1.-) (Very long-chain-fatty-acid-CoA ligase)	SLC27A2 ACSVL1 FACVL1 FATP2 VLACS	Homo sapiens (Human)	620	FUNCTION: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PubMed:20530735, PubMed:22022213, PubMed:24269233, PubMed:10198260, PubMed:10749848, PubMed:11980911). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:20530735, PubMed:22022213, PubMed:24269233, PubMed:10198260, PubMed:10749848, PubMed:11980911). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:20530735). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). May contribute to the synthesis of sphingosine-1-phosphate (PubMed:24269233). Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). However, it is not critical for THCA activation and bile synthesis in vivo (PubMed:20530735). {ECO:0000269|PubMed:10198260, ECO:0000269|PubMed:10749848, ECO:0000269|PubMed:11980911, ECO:0000269|PubMed:20530735, ECO:0000269|PubMed:22022213, ECO:0000269|PubMed:24269233}.; FUNCTION: [Isoform 1]: Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids (PubMed:21768100, PubMed:10198260). Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol (PubMed:21768100). {ECO:0000269|PubMed:10198260, ECO:0000269|PubMed:21768100}.; FUNCTION: [Isoform 2]: Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids. {ECO:0000269|PubMed:21768100}.		bile acid biosynthetic process [GO:0006699]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; fatty-acyl-CoA biosynthetic process [GO:0046949]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; methyl-branched fatty acid metabolic process [GO:0097089]; very long-chain fatty acid catabolic process [GO:0042760]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; cholate-CoA ligase activity [GO:0047747]; enzyme binding [GO:0019899]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oleate transmembrane transporter activity [GO:1901480]; phytanate-CoA ligase activity [GO:0050197]; pristanate-CoA ligase activity [GO:0070251]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; cholate-CoA ligase activity [GO:0047747]; enzyme binding [GO:0019899]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oleate transmembrane transporter activity [GO:1901480]; phytanate-CoA ligase activity [GO:0050197]; pristanate-CoA ligase activity [GO:0070251]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; bile acid biosynthetic process [GO:0006699]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; fatty-acyl-CoA biosynthetic process [GO:0046949]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; methyl-branched fatty acid metabolic process [GO:0097089]; very long-chain fatty acid catabolic process [GO:0042760]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11980911, ECO:0000269|PubMed:22022213, ECO:0000269|PubMed:24269233}; Multi-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000269|PubMed:10198260, ECO:0000269|PubMed:10640429}; Peripheral membrane protein {ECO:0000269|PubMed:10640429}. Cell membrane {ECO:0000269|PubMed:20530735}; Multi-pass membrane protein {ECO:0000255}. Microsome {ECO:0000269|PubMed:10640429}.
O14976	reviewed	GAK_HUMAN	Cyclin-G-associated kinase (EC 2.7.11.1)	GAK	Homo sapiens (Human)	1311	FUNCTION: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. {ECO:0000269|PubMed:10625686}.		cell cycle [GO:0007049]; chaperone cofactor-dependent protein refolding [GO:0051085]; clathrin coat assembly [GO:0048268]; clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; Golgi to lysosome transport [GO:0090160]; negative regulation of neuron projection development [GO:0010977]; phosphorylation [GO:0016310]; protein localization to Golgi apparatus [GO:0034067]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis [GO:0006898]; synaptic vesicle uncoating [GO:0016191]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; vesicle [GO:0031982]	ATP binding [GO:0005524]; clathrin binding [GO:0030276]; cyclin binding [GO:0030332]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; vesicle [GO:0031982]; ATP binding [GO:0005524]; clathrin binding [GO:0030276]; cyclin binding [GO:0030332]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-folding chaperone binding [GO:0051087]; cell cycle [GO:0007049]; chaperone cofactor-dependent protein refolding [GO:0051085]; clathrin coat assembly [GO:0048268]; clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; Golgi to lysosome transport [GO:0090160]; negative regulation of neuron projection development [GO:0010977]; phosphorylation [GO:0016310]; protein localization to Golgi apparatus [GO:0034067]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis [GO:0006898]; synaptic vesicle uncoating [GO:0016191]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10625686}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:10625686}. Cell junction, focal adhesion {ECO:0000305|PubMed:10625686}. Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.
O14977	reviewed	AZIN1_HUMAN	Antizyme inhibitor 1 (AZI) (AZI1) (Ornithine decarboxylase antizyme inhibitor)	AZIN1 OAZI OAZIN	Homo sapiens (Human)	448	FUNCTION: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). {ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:26305948}.		negative regulation of protein catabolic process [GO:0042177]; positive regulation of polyamine transmembrane transport [GO:1902269]; putrescine biosynthetic process from ornithine [GO:0033387]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ornithine decarboxylase activator activity [GO:0042978]; ornithine decarboxylase activity [GO:0004586]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ornithine decarboxylase activator activity [GO:0042978]; ornithine decarboxylase activity [GO:0004586]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of polyamine transmembrane transport [GO:1902269]; putrescine biosynthetic process from ornithine [GO:0033387]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O35484}.
O14978	reviewed	ZN263_HUMAN	Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12)	ZNF263 FPM315 ZKSCAN12	Homo sapiens (Human)	683	FUNCTION: Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030). {ECO:0000269|PubMed:32051553, ECO:0000269|PubMed:32277030}.	MISCELLANEOUS: May be involved in the EGFR-mediated promotion of invasion and anchorage-independent growth in glioblastomas via silencing of SIX3 (PubMed:32051553). May act as a prognostic indicator in glioblastoma patients, with increased expression correlating with poor prognosis (PubMed:32051553). {ECO:0000269|PubMed:32051553}.	negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32051553}.
O14979	reviewed	HNRDL_HUMAN	Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1)	HNRNPDL HNRPDL JKTBP	Homo sapiens (Human)	420	FUNCTION: Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. {ECO:0000250, ECO:0000269|PubMed:9538234}.		regulation of gene expression [GO:0010468]; RNA processing [GO:0006396]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; poly(A) binding [GO:0008143]; poly(G) binding [GO:0034046]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; poly(A) binding [GO:0008143]; poly(G) binding [GO:0034046]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; regulation of gene expression [GO:0010468]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11705999, ECO:0000269|PubMed:12406575}. Cytoplasm {ECO:0000269|PubMed:11705999, ECO:0000269|PubMed:12406575}. Note=Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner. {ECO:0000269|PubMed:11705999, ECO:0000269|PubMed:12406575}.
O14980	reviewed	XPO1_HUMAN	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)	XPO1 CRM1	Homo sapiens (Human)	1071	FUNCTION: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}.	MISCELLANEOUS: Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor.	mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611]; protein localization to nucleus [GO:0034504]; regulation of centrosome duplication [GO:0010824]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein export from nucleus [GO:0046825]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; ribosomal subunit export from nucleus [GO:0000054]; ribosome biogenesis [GO:0042254]	annulate lamellae [GO:0005642]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]	nuclear export signal receptor activity [GO:0005049]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]	annulate lamellae [GO:0005642]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; nuclear export signal receptor activity [GO:0005049]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611]; protein localization to nucleus [GO:0034504]; regulation of centrosome duplication [GO:0010824]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein export from nucleus [GO:0046825]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; ribosomal subunit export from nucleus [GO:0000054]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.
O14981	reviewed	BTAF1_HUMAN	TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172)	BTAF1 TAF172	Homo sapiens (Human)	1849	FUNCTION: Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.		negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA-templated transcription [GO:0045892]	intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; TBP-class protein binding [GO:0017025]; transcription coregulator activity [GO:0003712]	intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; TBP-class protein binding [GO:0017025]; transcription coregulator activity [GO:0003712]; negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus.
O14983	reviewed	AT2A1_HUMAN	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)	ATP2A1	Homo sapiens (Human)	1001	FUNCTION: Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}.		apoptotic mitochondrial changes [GO:0008637]; calcium ion import [GO:0070509]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; maintenance of mitochondrion location [GO:0051659]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of striated muscle contraction [GO:0045988]; positive regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901896]; positive regulation of calcium ion import into sarcoplasmic reticulum [GO:1902082]; positive regulation of cardiac muscle cell contraction [GO:0106134]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; positive regulation of fast-twitch skeletal muscle fiber contraction [GO:0031448]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; regulation of cardiac conduction [GO:1903779]; regulation of striated muscle contraction [GO:0006942]; relaxation of skeletal muscle [GO:0090076]; response to endoplasmic reticulum stress [GO:0034976]	calcium channel complex [GO:0034704]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; H zone [GO:0031673]; I band [GO:0031674]; membrane [GO:0016020]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; calcium-dependent ATPase activity [GO:0030899]; P-type calcium transporter activity [GO:0005388]; protein homodimerization activity [GO:0042803]	calcium channel complex [GO:0034704]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; H zone [GO:0031673]; I band [GO:0031674]; membrane [GO:0016020]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; calcium-dependent ATPase activity [GO:0030899]; P-type calcium transporter activity [GO:0005388]; protein homodimerization activity [GO:0042803]; apoptotic mitochondrial changes [GO:0008637]; calcium ion import [GO:0070509]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; maintenance of mitochondrion location [GO:0051659]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of striated muscle contraction [GO:0045988]; positive regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901896]; positive regulation of calcium ion import into sarcoplasmic reticulum [GO:1902082]; positive regulation of cardiac muscle cell contraction [GO:0106134]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; positive regulation of fast-twitch skeletal muscle fiber contraction [GO:0031448]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; regulation of cardiac conduction [GO:1903779]; regulation of striated muscle contraction [GO:0006942]; relaxation of skeletal muscle [GO:0090076]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04191}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04191}.
O14986	reviewed	PI51B_HUMAN	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (Protein STM-7) (Type I phosphatidylinositol 4-phosphate 5-kinase beta)	PIP5K1B STM7	Homo sapiens (Human)	540	FUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). {ECO:0000250|UniProtKB:P70181, ECO:0000250|UniProtKB:Q99755}.		phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; uropod [GO:0001931]	1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; phosphatidylinositol kinase activity [GO:0052742]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; uropod [GO:0001931]; 1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; phosphatidylinositol kinase activity [GO:0052742]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P70181}. Cell membrane {ECO:0000250|UniProtKB:P70181}. Endomembrane system. Note=Associated with membranes. {ECO:0000250}.
O14994	reviewed	SYN3_HUMAN	Synapsin-3 (Synapsin III)	SYN3	Homo sapiens (Human)	580	FUNCTION: May be involved in the regulation of neurotransmitter release and synaptogenesis.	MISCELLANEOUS: Regulated by calcium. Calcium inhibits ATP binding to the C-domain.	neurotransmitter secretion [GO:0007269]; regulation of synaptic transmission, GABAergic [GO:0032228]; synaptic vesicle clustering [GO:0097091]	extrinsic component of synaptic vesicle membrane [GO:0098850]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	ATP binding [GO:0005524]	extrinsic component of synaptic vesicle membrane [GO:0098850]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; ATP binding [GO:0005524]; neurotransmitter secretion [GO:0007269]; regulation of synaptic transmission, GABAergic [GO:0032228]; synaptic vesicle clustering [GO:0097091]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.
O15013	reviewed	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	ARHGEF10 KIAA0294	Homo sapiens (Human)	1369	FUNCTION: May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}.		actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; centrosome duplication [GO:0051298]; mitotic spindle assembly [GO:0090307]; myelination in peripheral nervous system [GO:0022011]; positive regulation of stress fiber assembly [GO:0051496]; regulation of small GTPase mediated signal transduction [GO:0051056]	centrosome [GO:0005813]; cytosol [GO:0005829]	guanyl-nucleotide exchange factor activity [GO:0005085]; kinesin binding [GO:0019894]	centrosome [GO:0005813]; cytosol [GO:0005829]; guanyl-nucleotide exchange factor activity [GO:0005085]; kinesin binding [GO:0019894]; actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; centrosome duplication [GO:0051298]; mitotic spindle assembly [GO:0090307]; myelination in peripheral nervous system [GO:0022011]; positive regulation of stress fiber assembly [GO:0051496]; regulation of small GTPase mediated signal transduction [GO:0051056]	
O15014	reviewed	ZN609_HUMAN	Zinc finger protein 609	ZNF609 KIAA0295	Homo sapiens (Human)	1411	FUNCTION: Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}.	MISCELLANEOUS: [Isoform 2]: Produced by a back-splicing reaction which joins the 5'-splice site of the first coding exon with the 3'-splice site of the upstream intron resulting in a circular RNA, called circ-ZNF609. The translation starts with the same initiator methionine as that of the linear transcript encoding isoform 1. The stop codon is created upon circularization. {ECO:0000269|PubMed:28344082}.	muscle organ development [GO:0007517]; positive regulation of neuron migration [GO:2001224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myoblast proliferation [GO:2000291]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; muscle organ development [GO:0007517]; positive regulation of neuron migration [GO:2001224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myoblast proliferation [GO:2000291]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:28344082}.
O15015	reviewed	ZN646_HUMAN	Zinc finger protein 646	ZNF646 KIAA0296	Homo sapiens (Human)	1832	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O15018	reviewed	PDZD2_HUMAN	PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2]	PDZD2 AIPC KIAA0300 PDZK3	Homo sapiens (Human)	2839		MISCELLANEOUS: [Isoform 2]: May be due to aberrant splicing. {ECO:0000305}.	cell adhesion [GO:0007155]	cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9QZR8}. Cytoplasm {ECO:0000269|PubMed:11289102}. Endoplasmic reticulum {ECO:0000269|PubMed:11289102}. Note=At cell-cell contacts in lung epithelial cells. {ECO:0000250|UniProtKB:Q9QZR8}.; SUBCELLULAR LOCATION: [Processed PDZ domain-containing protein 2]: Secreted {ECO:0000250}.
O15020	reviewed	SPTN2_HUMAN	Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)	SPTBN2 KIAA0302 SCA5	Homo sapiens (Human)	2390	FUNCTION: Probably plays an important role in neuronal membrane skeleton.		actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; adult behavior [GO:0030534]; cerebellar Purkinje cell layer morphogenesis [GO:0021692]; multicellular organism growth [GO:0035264]; regulation of postsynaptic specialization assembly [GO:0099150]; synapse assembly [GO:0007416]; vesicle-mediated transport [GO:0016192]	apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; parallel fiber to Purkinje cell synapse [GO:0098688]; paranodal junction [GO:0033010]; plasma membrane [GO:0005886]; postsynaptic spectrin-associated cytoskeleton [GO:0099189]; presynapse [GO:0098793]; spectrin [GO:0008091]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; phospholipid binding [GO:0005543]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynapse [GO:0099186]; structural constituent of synapse [GO:0098918]	apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; parallel fiber to Purkinje cell synapse [GO:0098688]; paranodal junction [GO:0033010]; plasma membrane [GO:0005886]; postsynaptic spectrin-associated cytoskeleton [GO:0099189]; presynapse [GO:0098793]; spectrin [GO:0008091]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; phospholipid binding [GO:0005543]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynapse [GO:0099186]; structural constituent of synapse [GO:0098918]; actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; adult behavior [GO:0030534]; cerebellar Purkinje cell layer morphogenesis [GO:0021692]; multicellular organism growth [GO:0035264]; regulation of postsynaptic specialization assembly [GO:0099150]; synapse assembly [GO:0007416]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
O15021	reviewed	MAST4_HUMAN	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1)	MAST4 KIAA0303	Homo sapiens (Human)	2623			cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
O15027	reviewed	SC16A_HUMAN	Protein transport protein Sec16A (SEC16 homolog A) (p250)	SEC16A KIAA0310 SEC16 SEC16L	Homo sapiens (Human)	2357	FUNCTION: Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:17005010, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}.		autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; Golgi to plasma membrane transport [GO:0006893]; protein exit from endoplasmic reticulum [GO:0032527]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; response to endoplasmic reticulum stress [GO:0034976]; substantia nigra development [GO:0021762]	cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; organelle membrane [GO:0031090]; perinuclear region of cytoplasm [GO:0048471]		cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; organelle membrane [GO:0031090]; perinuclear region of cytoplasm [GO:0048471]; autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; Golgi to plasma membrane transport [GO:0006893]; protein exit from endoplasmic reticulum [GO:0032527]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; response to endoplasmic reticulum stress [GO:0034976]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:29300766}; Peripheral membrane protein {ECO:0000269|PubMed:17005010}. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:E9QAT4}. Cytoplasm, cytosol {ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384}. Microsome membrane {ECO:0000269|PubMed:17428803}. Note=SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation (PubMed:17192411). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). MIA3 and LRRK2 are required for its proper localization to ERES (PubMed:25201882, PubMed:28442536, PubMed:19638414, PubMed:17428803, PubMed:22355596). Recruited to microsomal membrane in SAR1-dependent manner (PubMed:17428803). {ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:19638414, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:28442536}.
O15031	reviewed	PLXB2_HUMAN	Plexin-B2 (MM1)	PLXNB2 KIAA0315	Homo sapiens (Human)	1838	FUNCTION: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458). Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888). May modulate the activity of RAC1 and CDC42 (By similarity). {ECO:0000250|UniProtKB:B2RXS4, ECO:0000269|PubMed:12183458, ECO:0000269|PubMed:15184888}.		brain development [GO:0007420]; excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; neural tube closure [GO:0001843]; neuroblast proliferation [GO:0007405]; positive regulation of axonogenesis [GO:0050772]; positive regulation of neuron projection development [GO:0010976]; positive regulation of translation [GO:0045727]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of neuron migration [GO:2001222]; regulation of protein phosphorylation [GO:0001932]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	semaphorin receptor activity [GO:0017154]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]; semaphorin receptor activity [GO:0017154]; brain development [GO:0007420]; excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; neural tube closure [GO:0001843]; neuroblast proliferation [GO:0007405]; positive regulation of axonogenesis [GO:0050772]; positive regulation of neuron projection development [GO:0010976]; positive regulation of translation [GO:0045727]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of neuron migration [GO:2001222]; regulation of protein phosphorylation [GO:0001932]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12533544}; Single-pass type I membrane protein {ECO:0000255}.
O15033	reviewed	AREL1_HUMAN	Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1)	AREL1 KIAA0317	Homo sapiens (Human)	823	FUNCTION: E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages (PubMed:25752577). E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:23479728, PubMed:31578312). Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro (PubMed:23479728). Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312). {ECO:0000269|PubMed:23479728, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:31578312}.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; protein K11-linked ubiquitination [GO:0070979]; protein K33-linked ubiquitination [GO:1990390]; protein ubiquitination [GO:0016567]; regulation of inflammatory response [GO:0050727]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; protein K11-linked ubiquitination [GO:0070979]; protein K33-linked ubiquitination [GO:1990390]; protein ubiquitination [GO:0016567]; regulation of inflammatory response [GO:0050727]; ubiquitin-dependent protein catabolic process [GO:0006511]	
O15040	reviewed	TCPR2_HUMAN	Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297)	TECPR2 KIAA0297 KIAA0329	Homo sapiens (Human)	1411	FUNCTION: Probably plays a role as positive regulator of autophagy. {ECO:0000269|PubMed:23176824}.		autophagy [GO:0006914]; protein exit from endoplasmic reticulum [GO:0032527]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; autophagy [GO:0006914]; protein exit from endoplasmic reticulum [GO:0032527]	
O15041	reviewed	SEM3E_HUMAN	Semaphorin-3E	SEMA3E KIAA0331 SEMAH	Homo sapiens (Human)	775	FUNCTION: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; branching involved in blood vessel morphogenesis [GO:0001569]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative chemotaxis [GO:0050919]; negative regulation of angiogenesis [GO:0016525]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron apoptotic process [GO:0043524]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; sprouting angiogenesis [GO:0002040]; synapse organization [GO:0050808]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	chemorepellent activity [GO:0045499]; receptor ligand activity [GO:0048018]; semaphorin receptor binding [GO:0030215]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; chemorepellent activity [GO:0045499]; receptor ligand activity [GO:0048018]; semaphorin receptor binding [GO:0030215]; axon guidance [GO:0007411]; branching involved in blood vessel morphogenesis [GO:0001569]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative chemotaxis [GO:0050919]; negative regulation of angiogenesis [GO:0016525]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron apoptotic process [GO:0043524]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; sprouting angiogenesis [GO:0002040]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
O15042	reviewed	SR140_HUMAN	U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140)	U2SURP KIAA0332 SR140	Homo sapiens (Human)	1029			RNA processing [GO:0006396]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20858735}.
O15047	reviewed	SET1A_HUMAN	Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)	SETD1A KIAA0339 KMT2F SET1 SET1A	Homo sapiens (Human)	1707	FUNCTION: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:25561738, PubMed:12670868). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159}.		brain development [GO:0007420]; DNA damage response [GO:0006974]; methylation [GO:0032259]; regulation of chromatin organization [GO:1902275]; regulation of hematopoietic stem cell differentiation [GO:1902036]	chromatin [GO:0000785]; histone methyltransferase complex [GO:0035097]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]	beta-catenin binding [GO:0008013]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	chromatin [GO:0000785]; histone methyltransferase complex [GO:0035097]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]; beta-catenin binding [GO:0008013]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; brain development [GO:0007420]; DNA damage response [GO:0006974]; methylation [GO:0032259]; regulation of chromatin organization [GO:1902275]; regulation of hematopoietic stem cell differentiation [GO:1902036]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:17355966}. Chromosome {ECO:0000269|PubMed:17355966}. Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes.
O15049	reviewed	N4BP3_HUMAN	NEDD4-binding protein 3 (N4BP3)	N4BP3 KIAA0341	Homo sapiens (Human)	544	FUNCTION: Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}.		innate immune response [GO:0045087]; nervous system development [GO:0007399]	axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]		axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; innate immune response [GO:0045087]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:11717310}. Cell projection, axon {ECO:0000250|UniProtKB:Q3LUD3}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q3LUD3}. Note=In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites. {ECO:0000250|UniProtKB:Q3LUD3}.
O15054	reviewed	KDM6B_HUMAN	Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B)	KDM6B JMJD3 KIAA0346	Homo sapiens (Human)	1643	FUNCTION: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). {ECO:0000250|UniProtKB:Q5NCY0, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17825402, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914, ECO:0000269|PubMed:28262558}.		cardiac muscle cell differentiation [GO:0055007]; cell fate commitment [GO:0045165]; cellular response to hydrogen peroxide [GO:0070301]; chromatin remodeling [GO:0006338]; endothelial cell differentiation [GO:0045446]; hippocampus development [GO:0021766]; inflammatory response to antigenic stimulus [GO:0002437]; mesodermal cell differentiation [GO:0048333]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; response to activity [GO:0014823]; response to fungicide [GO:0060992]	MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cardiac muscle cell differentiation [GO:0055007]; cell fate commitment [GO:0045165]; cellular response to hydrogen peroxide [GO:0070301]; chromatin remodeling [GO:0006338]; endothelial cell differentiation [GO:0045446]; hippocampus development [GO:0021766]; inflammatory response to antigenic stimulus [GO:0002437]; mesodermal cell differentiation [GO:0048333]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; response to activity [GO:0014823]; response to fungicide [GO:0060992]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:17825402}.
O15055	reviewed	PER2_HUMAN	Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2)	PER2 KIAA0347	Homo sapiens (Human)	1255	FUNCTION: Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}.		chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; circadian regulation of translation [GO:0097167]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; fatty acid metabolic process [GO:0006631]; gluconeogenesis [GO:0006094]; glycogen biosynthetic process [GO:0005978]; lactate biosynthetic process [GO:0019249]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946]; regulation of insulin secretion [GO:0050796]; regulation of neurogenesis [GO:0050767]; regulation of vasoconstriction [GO:0019229]; response to ischemia [GO:0002931]; white fat cell differentiation [GO:0050872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor binding [GO:0001222]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor binding [GO:0001222]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; circadian regulation of translation [GO:0097167]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; fatty acid metabolic process [GO:0006631]; gluconeogenesis [GO:0006094]; glycogen biosynthetic process [GO:0005978]; lactate biosynthetic process [GO:0019249]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946]; regulation of insulin secretion [GO:0050796]; regulation of neurogenesis [GO:0050767]; regulation of vasoconstriction [GO:0019229]; response to ischemia [GO:0002931]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:22274616}. Cytoplasm {ECO:0000250|UniProtKB:O54943}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54943}. Note=Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2. PML regulates its nuclear localization. {ECO:0000250|UniProtKB:O54943}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, nucleolus {ECO:0000269|PubMed:24202686}.
O15056	reviewed	SYNJ2_HUMAN	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2)	SYNJ2 KIAA0348	Homo sapiens (Human)	1496	FUNCTION: Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.		membrane organization [GO:0061024]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; synaptic vesicle endocytosis [GO:0048488]	cell projection [GO:0042995]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]	cell projection [GO:0042995]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]; membrane organization [GO:0061024]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11084340}. Cell membrane {ECO:0000269|PubMed:11084340}. Membrane raft {ECO:0000269|PubMed:11084340}. Presynapse {ECO:0000250|UniProtKB:O55207}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O55207}. Note=Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340). {ECO:0000269|PubMed:11084340}.
O15060	reviewed	ZBT39_HUMAN	Zinc finger and BTB domain-containing protein 39	ZBTB39 KIAA0352	Homo sapiens (Human)	712	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	nucleoplasm [GO:0005654]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O15061	reviewed	SYNEM_HUMAN	Synemin (Desmuslin)	SYNM DMN KIAA0353 SYN	Homo sapiens (Human)	1565	FUNCTION: Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.		fast-twitch skeletal muscle fiber contraction [GO:0031443]; intermediate filament cytoskeleton organization [GO:0045104]	adherens junction [GO:0005912]; costamere [GO:0043034]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; neurofilament cytoskeleton [GO:0060053]; sarcolemma [GO:0042383]	intermediate filament binding [GO:0019215]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; vinculin binding [GO:0017166]	adherens junction [GO:0005912]; costamere [GO:0043034]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; neurofilament cytoskeleton [GO:0060053]; sarcolemma [GO:0042383]; intermediate filament binding [GO:0019215]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; vinculin binding [GO:0017166]; fast-twitch skeletal muscle fiber contraction [GO:0031443]; intermediate filament cytoskeleton organization [GO:0045104]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere.
O15062	reviewed	ZBTB5_HUMAN	Zinc finger and BTB domain-containing protein 5	ZBTB5 KIAA0354	Homo sapiens (Human)	677	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O15066	reviewed	KIF3B_HUMAN	Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed]	KIF3B KIAA0359	Homo sapiens (Human)	747	FUNCTION: Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity). Plays a role in cilia formation (PubMed:32386558). Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (PubMed:32386558). Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (By similarity). {ECO:0000250|UniProtKB:Q61771, ECO:0000269|PubMed:32386558}.		anterograde axonal transport [GO:0008089]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; intraciliary transport [GO:0042073]; microtubule-based movement [GO:0007018]; mitotic centrosome separation [GO:0007100]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; opsin transport [GO:0036372]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of cytokinesis [GO:0032467]; vesicle-mediated transport [GO:0016192]	axon cytoplasm [GO:1904115]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; kinesin complex [GO:0005871]; kinesin II complex [GO:0016939]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; plus-end kinesin complex [GO:0005873]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; intraciliary transport particle B binding [GO:0120170]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; small GTPase binding [GO:0031267]	axon cytoplasm [GO:1904115]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; kinesin complex [GO:0005871]; kinesin II complex [GO:0016939]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; plus-end kinesin complex [GO:0005873]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; intraciliary transport particle B binding [GO:0120170]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; small GTPase binding [GO:0031267]; anterograde axonal transport [GO:0008089]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; intraciliary transport [GO:0042073]; microtubule-based movement [GO:0007018]; mitotic centrosome separation [GO:0007100]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; opsin transport [GO:0036372]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of cytokinesis [GO:0032467]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:Q61771}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q61771}.
O15067	reviewed	PUR4_HUMAN	Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase)	PFAS KIAA0361	Homo sapiens (Human)	1338	FUNCTION: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}.		'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; anterior head development [GO:0097065]; glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to xenobiotic stimulus [GO:0009410]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylformylglycinamidine synthase activity [GO:0004642]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylformylglycinamidine synthase activity [GO:0004642]; 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; anterior head development [GO:0097065]; glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O15068	reviewed	MCF2L_HUMAN	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein)	MCF2L KIAA0362 OST	Homo sapiens (Human)	1137	FUNCTION: Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). {ECO:0000250|UniProtKB:Q63406, ECO:0000269|PubMed:15157669}.; FUNCTION: [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669). {ECO:0000269|PubMed:15157669}.		intracellular signal transduction [GO:0035556]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; extracellular space [GO:0005615]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol binding [GO:0035091]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; extracellular space [GO:0005615]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol binding [GO:0035091]; intracellular signal transduction [GO:0035556]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:15157669}. Cell membrane {ECO:0000269|PubMed:15157669}; Peripheral membrane protein {ECO:0000269|PubMed:15157669}; Cytoplasmic side {ECO:0000269|PubMed:15157669}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:15157669}. Endomembrane system {ECO:0000269|PubMed:15157669}. Note=Interaction with membranes enriched in phosphoinositides is mediated by the CRAL-TRIO domain. {ECO:0000269|PubMed:15157669}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q64096}. Cell membrane {ECO:0000250|UniProtKB:Q64096}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64096}; Cytoplasmic side {ECO:0000250|UniProtKB:Q64096}.
O15072	reviewed	ATS3_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (EC 3.4.24.-) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme)	ADAMTS3 KIAA0366	Homo sapiens (Human)	1205	FUNCTION: Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.		collagen biosynthetic process [GO:0032964]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; in utero embryonic development [GO:0001701]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; protein processing [GO:0016485]; supramolecular fiber organization [GO:0097435]; vascular endothelial growth factor production [GO:0010573]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	endopeptidase activity [GO:0004175]; heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; endopeptidase activity [GO:0004175]; heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; collagen biosynthetic process [GO:0032964]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; in utero embryonic development [GO:0001701]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; protein processing [GO:0016485]; supramolecular fiber organization [GO:0097435]; vascular endothelial growth factor production [GO:0010573]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28985353}. Secreted, extracellular space, extracellular matrix {ECO:0000250}.
O15075	reviewed	DCLK1_HUMAN	Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)	DCLK1 DCAMKL1 DCDC3A KIAA0369	Homo sapiens (Human)	740	FUNCTION: Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.		axon extension [GO:0048675]; central nervous system development [GO:0007417]; central nervous system projection neuron axonogenesis [GO:0021952]; dendrite morphogenesis [GO:0048813]; endosomal transport [GO:0016197]; forebrain development [GO:0030900]; intracellular signal transduction [GO:0035556]; negative regulation of protein localization to nucleus [GO:1900181]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; neuron projection morphogenesis [GO:0048812]; protein localization to nucleus [GO:0034504]; protein phosphorylation [GO:0006468]; response to virus [GO:0009615]	plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; axon extension [GO:0048675]; central nervous system development [GO:0007417]; central nervous system projection neuron axonogenesis [GO:0021952]; dendrite morphogenesis [GO:0048813]; endosomal transport [GO:0016197]; forebrain development [GO:0030900]; intracellular signal transduction [GO:0035556]; negative regulation of protein localization to nucleus [GO:1900181]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; neuron projection morphogenesis [GO:0048812]; protein localization to nucleus [GO:0034504]; protein phosphorylation [GO:0006468]; response to virus [GO:0009615]	
O15078	reviewed	CE290_HUMAN	Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2)	CEP290 BBS14 KIAA0373 NPHP6	Homo sapiens (Human)	2479	FUNCTION: Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973). {ECO:0000250|UniProtKB:Q6A078, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17705300, ECO:0000269|PubMed:18694559, ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:25552655}.		camera-type eye development [GO:0043010]; ciliary basal body-plasma membrane docking [GO:0097711]; ciliary transition zone assembly [GO:1905349]; cilium assembly [GO:0060271]; eye photoreceptor cell development [GO:0042462]; hindbrain development [GO:0030902]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515]; otic vesicle formation [GO:0030916]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular protein transport [GO:0090316]; pronephros development [GO:0048793]; protein transport [GO:0015031]; regulation of establishment of protein localization [GO:0070201]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; MKS complex [GO:0036038]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580]	identical protein binding [GO:0042802]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; MKS complex [GO:0036038]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580]; identical protein binding [GO:0042802]; camera-type eye development [GO:0043010]; ciliary basal body-plasma membrane docking [GO:0097711]; ciliary transition zone assembly [GO:1905349]; cilium assembly [GO:0060271]; eye photoreceptor cell development [GO:0042462]; hindbrain development [GO:0030902]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515]; otic vesicle formation [GO:0030916]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular protein transport [GO:0090316]; pronephros development [GO:0048793]; protein transport [GO:0015031]; regulation of establishment of protein localization [GO:0070201]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:21493627, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22797915}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:17705300, ECO:0000269|PubMed:21493627, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:23943788, ECO:0000269|PubMed:24121310}. Nucleus {ECO:0000250|UniProtKB:Q6A078}. Cell projection, cilium {ECO:0000269|PubMed:23943788}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q6A078}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22797915}. Cytoplasmic vesicle {ECO:0000303|PubMed:24051377}. Note=Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (PubMed:24121310). Found in the connecting cilium of photoreceptor cells, base of cilium in kidney intramedullary collecting duct cells (By similarity). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:23943788). Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent (PubMed:23943788). {ECO:0000250|UniProtKB:Q6A078, ECO:0000269|PubMed:23943788, ECO:0000269|PubMed:24121310}.
O15079	reviewed	SNPH_HUMAN	Syntaphilin	SNPH KIAA0374	Homo sapiens (Human)	494	FUNCTION: Inhibits SNARE complex formation by absorbing free syntaxin-1. {ECO:0000269|PubMed:10707983}.		neuron differentiation [GO:0030182]; neurotransmitter secretion [GO:0007269]; synaptic vesicle docking [GO:0016081]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; presynapse [GO:0098793]	syntaxin-1 binding [GO:0017075]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; presynapse [GO:0098793]; syntaxin-1 binding [GO:0017075]; neuron differentiation [GO:0030182]; neurotransmitter secretion [GO:0007269]; synaptic vesicle docking [GO:0016081]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Synapse, synaptosome.
O15083	reviewed	ERC2_HUMAN	ERC protein 2	ERC2 KIAA0378	Homo sapiens (Human)	957	FUNCTION: Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.		maintenance of presynaptic active zone structure [GO:0048790]; neuromuscular synaptic transmission [GO:0007274]; regulation of calcium-dependent activation of synaptic vesicle fusion [GO:0150037]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic plasticity [GO:0048167]; synaptic vesicle priming [GO:0016082]	cytoskeleton of presynaptic active zone [GO:0048788]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]	structural constituent of presynaptic active zone [GO:0098882]	cytoskeleton of presynaptic active zone [GO:0048788]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; structural constituent of presynaptic active zone [GO:0098882]; maintenance of presynaptic active zone structure [GO:0048790]; neuromuscular synaptic transmission [GO:0007274]; regulation of calcium-dependent activation of synaptic vesicle fusion [GO:0150037]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic plasticity [GO:0048167]; synaptic vesicle priming [GO:0016082]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12923177}. Synapse {ECO:0000269|PubMed:12923177}. Presynaptic active zone {ECO:0000269|PubMed:12923177}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12923177}. Note=In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density (By similarity). {ECO:0000250}.
O15084	reviewed	ANR28_HUMAN	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK)	ANKRD28 KIAA0379	Homo sapiens (Human)	1053	FUNCTION: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. {ECO:0000269|PubMed:16564677, ECO:0000269|PubMed:18186651}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000305}.		cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:16564677}. Note=Seems to be excluded from nucleoli.
O15085	reviewed	ARHGB_HUMAN	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)	ARHGEF11 KIAA0380	Homo sapiens (Human)	1522	FUNCTION: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}.		actin cytoskeleton organization [GO:0030036]; establishment of cell polarity [GO:0030010]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell growth [GO:0001558]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; striated muscle contraction [GO:0006941]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; actin cytoskeleton organization [GO:0030036]; establishment of cell polarity [GO:0030010]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell growth [GO:0001558]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; striated muscle contraction [GO:0006941]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10900204}. Membrane {ECO:0000269|PubMed:10900204}. Note=Translocated to the membrane upon stimulation.
O15091	reviewed	MRPP3_HUMAN	Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) (Protein only RNase P catalytic subunit)	PRORP KIAA0391 MRPP3	Homo sapiens (Human)	583	FUNCTION: Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853, PubMed:34715011). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853). {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:25953853, ECO:0000269|PubMed:34715011}.		mitochondrial tRNA 5'-end processing [GO:0097745]; tRNA 5'-leader removal [GO:0001682]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; ribonuclease P activity [GO:0004526]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; ribonuclease P activity [GO:0004526]; mitochondrial tRNA 5'-end processing [GO:0097745]; tRNA 5'-leader removal [GO:0001682]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18984158}.
O15105	reviewed	SMAD7_HUMAN	Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)	SMAD7 MADH7 MADH8	Homo sapiens (Human)	426	FUNCTION: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access (PubMed:21791611). Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:11163210, ECO:0000269|PubMed:12023024, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:9892009}.		adherens junction assembly [GO:0034333]; anatomical structure morphogenesis [GO:0009653]; artery morphogenesis [GO:0048844]; cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to transforming growth factor beta stimulus [GO:0071560]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell migration [GO:0030336]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ossification [GO:0030279]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper 17 type immune response [GO:2000317]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of chondrocyte hypertrophy [GO:1903043]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein stabilization [GO:0050821]; protein-containing complex localization [GO:0031503]; regulation of cardiac muscle contraction [GO:0055117]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; response to laminar fluid shear stress [GO:0034616]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular septum morphogenesis [GO:0060412]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; heteromeric SMAD protein complex [GO:0071144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	activin receptor binding [GO:0070697]; beta-catenin binding [GO:0008013]; collagen binding [GO:0005518]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; transcription regulator inhibitor activity [GO:0140416]; type I transforming growth factor beta receptor binding [GO:0034713]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; heteromeric SMAD protein complex [GO:0071144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; activin receptor binding [GO:0070697]; beta-catenin binding [GO:0008013]; collagen binding [GO:0005518]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; transcription regulator inhibitor activity [GO:0140416]; type I transforming growth factor beta receptor binding [GO:0034713]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]; adherens junction assembly [GO:0034333]; anatomical structure morphogenesis [GO:0009653]; artery morphogenesis [GO:0048844]; cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to transforming growth factor beta stimulus [GO:0071560]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell migration [GO:0030336]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ossification [GO:0030279]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper 17 type immune response [GO:2000317]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of chondrocyte hypertrophy [GO:1903043]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein stabilization [GO:0050821]; protein-containing complex localization [GO:0031503]; regulation of cardiac muscle contraction [GO:0055117]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; response to laminar fluid shear stress [GO:0034616]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14657019, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17327236}. Cytoplasm {ECO:0000269|PubMed:14657019, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17327236}. Note=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). {ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17327236}.
O15111	reviewed	IKKA_HUMAN	Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)	CHUK IKKA TCF16	Homo sapiens (Human)	745	FUNCTION: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:9244310, PubMed:9252186, PubMed:9346484, PubMed:18626576). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:9244310, PubMed:9252186, PubMed:9346484, PubMed:18626576, PubMed:35952808). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:9244310, PubMed:9252186, PubMed:9346484, PubMed:18626576). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:9244310, PubMed:9252186, PubMed:9346484, PubMed:18626576). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}.		anatomical structure morphogenesis [GO:0009653]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to cadmium ion [GO:0071276]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; response to acetate [GO:0010034]; response to amino acid [GO:0043200]; response to cholecystokinin [GO:0061847]; response to hydroperoxide [GO:0033194]; response to lipopolysaccharide [GO:0032496]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; Rho protein signal transduction [GO:0007266]; skeletal muscle contraction [GO:0003009]; striated muscle cell differentiation [GO:0051146]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; IkappaB kinase activity [GO:0008384]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; transferrin receptor binding [GO:1990459]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; IkappaB kinase activity [GO:0008384]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; transferrin receptor binding [GO:1990459]; anatomical structure morphogenesis [GO:0009653]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to cadmium ion [GO:0071276]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; response to acetate [GO:0010034]; response to amino acid [GO:0043200]; response to cholecystokinin [GO:0061847]; response to hydroperoxide [GO:0033194]; response to lipopolysaccharide [GO:0032496]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; Rho protein signal transduction [GO:0007266]; skeletal muscle contraction [GO:0003009]; striated muscle cell differentiation [GO:0051146]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:30341167}. Nucleus {ECO:0000269|PubMed:12789342}. Note=Shuttles between the cytoplasm and the nucleus.
O15116	reviewed	LSM1_HUMAN	U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)	LSM1 CASM	Homo sapiens (Human)	133	FUNCTION: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). {ECO:0000250|UniProtKB:P47017, ECO:0000269|PubMed:18172165}.		deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; histone mRNA catabolic process [GO:0071044]; mRNA processing [GO:0006397]; negative regulation of neuron differentiation [GO:0045665]; neuron differentiation [GO:0030182]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; stem cell population maintenance [GO:0019827]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; Lsm1-7-Pat1 complex [GO:1990726]; messenger ribonucleoprotein complex [GO:1990124]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; P-body [GO:0000932]	mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; Lsm1-7-Pat1 complex [GO:1990726]; messenger ribonucleoprotein complex [GO:1990124]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; P-body [GO:0000932]; mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; histone mRNA catabolic process [GO:0071044]; mRNA processing [GO:0006397]; negative regulation of neuron differentiation [GO:0045665]; neuron differentiation [GO:0030182]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:18172165}. Cytoplasm, P-body {ECO:0000305|PubMed:18172165}.
O15117	reviewed	FYB1_HUMAN	FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)	FYB1 FYB SLAP130	Homo sapiens (Human)	783	FUNCTION: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}.		immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; protein localization to plasma membrane [GO:0072659]; T cell receptor signaling pathway [GO:0050852]	actin cytoskeleton [GO:0015629]; anchoring junction [GO:0070161]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	lipid binding [GO:0008289]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]	actin cytoskeleton [GO:0015629]; anchoring junction [GO:0070161]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; lipid binding [GO:0008289]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; protein localization to plasma membrane [GO:0072659]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9671755}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Cell junction {ECO:0000250|UniProtKB:O35601}. Note=Colocalizes with TMEM47 at cell-cell contacts in podocytes. {ECO:0000250|UniProtKB:O35601}.
O15118	reviewed	NPC1_HUMAN	NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein)	NPC1	Homo sapiens (Human)	1278	FUNCTION: Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:9211849, PubMed:9927649, PubMed:10821832, PubMed:18772377, PubMed:27238017, PubMed:12554680). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:9211849, PubMed:9927649, PubMed:18772377, PubMed:19563754, PubMed:27238017, PubMed:28784760). Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed:19563754). Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9 (PubMed:28336668). {ECO:0000269|PubMed:10821832, ECO:0000269|PubMed:12554680, ECO:0000269|PubMed:18772377, ECO:0000269|PubMed:19563754, ECO:0000269|PubMed:27238017, ECO:0000269|PubMed:28336668, ECO:0000269|PubMed:28784760, ECO:0000269|PubMed:9211849, ECO:0000269|PubMed:9927649, ECO:0000305}.; FUNCTION: (Microbial infection) Acts as an endosomal entry receptor for ebolavirus. {ECO:0000269|PubMed:21866103, ECO:0000269|PubMed:25855742, ECO:0000269|PubMed:32855215}.		adult walking behavior [GO:0007628]; autophagy [GO:0006914]; bile acid metabolic process [GO:0008206]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to steroid hormone stimulus [GO:0071383]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; cholesterol transport [GO:0030301]; cyclodextrin metabolic process [GO:2000900]; endocytosis [GO:0006897]; establishment of protein localization to membrane [GO:0090150]; gene expression [GO:0010467]; intestinal cholesterol absorption [GO:0030299]; intracellular cholesterol transport [GO:0032367]; liver development [GO:0001889]; lysosomal transport [GO:0007041]; macroautophagy [GO:0016236]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TORC1 signaling [GO:1904262]; neurogenesis [GO:0022008]; programmed cell death [GO:0012501]; protein glycosylation [GO:0006486]; response to cadmium ion [GO:0046686]; response to xenobiotic stimulus [GO:0009410]; viral entry into host cell [GO:0046718]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; signaling receptor activity [GO:0038023]; sterol transporter activity [GO:0015248]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; signaling receptor activity [GO:0038023]; sterol transporter activity [GO:0015248]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]; adult walking behavior [GO:0007628]; autophagy [GO:0006914]; bile acid metabolic process [GO:0008206]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to steroid hormone stimulus [GO:0071383]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; cholesterol transport [GO:0030301]; cyclodextrin metabolic process [GO:2000900]; endocytosis [GO:0006897]; establishment of protein localization to membrane [GO:0090150]; gene expression [GO:0010467]; intestinal cholesterol absorption [GO:0030299]; intracellular cholesterol transport [GO:0032367]; liver development [GO:0001889]; lysosomal transport [GO:0007041]; macroautophagy [GO:0016236]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TORC1 signaling [GO:1904262]; neurogenesis [GO:0022008]; programmed cell death [GO:0012501]; protein glycosylation [GO:0006486]; response to cadmium ion [GO:0046686]; response to xenobiotic stimulus [GO:0009410]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:12554680}; Multi-pass membrane protein {ECO:0000269|PubMed:10821832, ECO:0000269|PubMed:27238017, ECO:0000269|PubMed:28784760}. Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:9927649}; Multi-pass membrane protein {ECO:0000269|PubMed:10821832, ECO:0000269|PubMed:27238017, ECO:0000269|PubMed:28784760}.
O15119	reviewed	TBX3_HUMAN	T-box transcription factor TBX3 (T-box protein 3)	TBX3	Homo sapiens (Human)	743	FUNCTION: Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}.	MISCELLANEOUS: [Isoform II]: Contains an interrupted T-box domain.; MISCELLANEOUS: [Isoform III]: Contains an interrupted T-box domain. {ECO:0000305}.; MISCELLANEOUS: [Isoform IV]: May be produced by joining exon 1 to exon 7 thereby eliminating the T-box. {ECO:0000305}.	animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification, embryo [GO:0008595]; atrioventricular bundle cell differentiation [GO:0003167]; atrioventricular canal development [GO:0036302]; atrioventricular canal morphogenesis [GO:1905222]; blood vessel development [GO:0001568]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac jelly development [GO:1905072]; cardiac muscle cell fate commitment [GO:0060923]; cell fate specification [GO:0001708]; cellular senescence [GO:0090398]; DNA-templated transcription [GO:0006351]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cushion formation [GO:0003272]; female genitalia development [GO:0030540]; follicle-stimulating hormone secretion [GO:0046884]; forelimb morphogenesis [GO:0035136]; heart looping [GO:0001947]; hepatoblast differentiation [GO:0061017]; in utero embryonic development [GO:0001701]; limbic system development [GO:0021761]; luteinizing hormone secretion [GO:0032275]; male genitalia development [GO:0030539]; mammary gland development [GO:0030879]; mammary placode formation [GO:0060596]; mesoderm morphogenesis [GO:0048332]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation involved in heart morphogenesis [GO:2000137]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of protein complex stability [GO:0061635]; regulation of protein stability [GO:0031647]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; semicircular canal morphogenesis [GO:0048752]; sinoatrial node cell development [GO:0060931]; skeletal system development [GO:0001501]; smooth muscle cell differentiation [GO:0051145]; specification of animal organ position [GO:0010159]; stem cell population maintenance [GO:0019827]; stem cell proliferation [GO:0072089]; ureteric peristalsis [GO:0072105]; ventricular septum morphogenesis [GO:0060412]	chromatin [GO:0000785]; cilium [GO:0005929]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cilium [GO:0005929]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification, embryo [GO:0008595]; atrioventricular bundle cell differentiation [GO:0003167]; atrioventricular canal development [GO:0036302]; atrioventricular canal morphogenesis [GO:1905222]; blood vessel development [GO:0001568]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac jelly development [GO:1905072]; cardiac muscle cell fate commitment [GO:0060923]; cell fate specification [GO:0001708]; cellular senescence [GO:0090398]; DNA-templated transcription [GO:0006351]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cushion formation [GO:0003272]; female genitalia development [GO:0030540]; follicle-stimulating hormone secretion [GO:0046884]; forelimb morphogenesis [GO:0035136]; heart looping [GO:0001947]; hepatoblast differentiation [GO:0061017]; in utero embryonic development [GO:0001701]; limbic system development [GO:0021761]; luteinizing hormone secretion [GO:0032275]; male genitalia development [GO:0030539]; mammary gland development [GO:0030879]; mammary placode formation [GO:0060596]; mesoderm morphogenesis [GO:0048332]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation involved in heart morphogenesis [GO:2000137]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of protein complex stability [GO:0061635]; regulation of protein stability [GO:0031647]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; semicircular canal morphogenesis [GO:0048752]; sinoatrial node cell development [GO:0060931]; skeletal system development [GO:0001501]; smooth muscle cell differentiation [GO:0051145]; specification of animal organ position [GO:0010159]; stem cell population maintenance [GO:0019827]; stem cell proliferation [GO:0072089]; ureteric peristalsis [GO:0072105]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
O15120	reviewed	PLCB_HUMAN	1-acyl-sn-glycerol-3-phosphate acyltransferase beta (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 2) (1-AGP acyltransferase 2) (1-AGPAT 2) (Lysophosphatidic acid acyltransferase beta) (LPAAT-beta)	AGPAT2	Homo sapiens (Human)	278	FUNCTION: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269|PubMed:15629135, ECO:0000269|PubMed:19075029, ECO:0000269|PubMed:21873652, ECO:0000269|PubMed:9242711}.		CDP-diacylglycerol biosynthetic process [GO:0016024]; epidermis development [GO:0008544]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; response to xenobiotic stimulus [GO:0009410]; triglyceride biosynthetic process [GO:0019432]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; CDP-diacylglycerol biosynthetic process [GO:0016024]; epidermis development [GO:0008544]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; response to xenobiotic stimulus [GO:0009410]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21873652}; Multi-pass membrane protein {ECO:0000255}.
O15121	reviewed	DEGS1_HUMAN	Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Dihydroceramide desaturase-1) (Membrane lipid desaturase) (Retinol isomerase) (EC 5.2.1.-)	DEGS1 DES1 MLD MIG15	Homo sapiens (Human)	323	FUNCTION: Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (PubMed:11937514, PubMed:30620337, PubMed:30620338). Catalyzes the equilibrium isomerization of retinols (By similarity). {ECO:0000250|UniProtKB:Q5F3C1, ECO:0000269|PubMed:11937514, ECO:0000269|PubMed:30620337, ECO:0000269|PubMed:30620338}.		ceramide biosynthetic process [GO:0046513]; myelin maintenance [GO:0043217]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	electron transfer activity [GO:0009055]; retinol isomerase activity [GO:0050251]; sphingolipid delta-4 desaturase activity [GO:0042284]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; electron transfer activity [GO:0009055]; retinol isomerase activity [GO:0050251]; sphingolipid delta-4 desaturase activity [GO:0042284]; ceramide biosynthetic process [GO:0046513]; myelin maintenance [GO:0043217]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:19647031, ECO:0000269|PubMed:30620338}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19647031, ECO:0000269|PubMed:30620338, ECO:0000269|PubMed:9188692}; Multi-pass membrane protein {ECO:0000269|PubMed:19647031, ECO:0000269|PubMed:9188692}.
O15123	reviewed	ANGP2_HUMAN	Angiopoietin-2 (ANG-2)	ANGPT2	Homo sapiens (Human)	496	FUNCTION: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Involved in the regulation of lymphangiogenesis (PubMed:32908006). {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:19116766, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:32908006, ECO:0000269|PubMed:9204896}.		angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; cellular response to growth factor stimulus [GO:0071363]; gene expression [GO:0010467]; germ cell development [GO:0007281]; glomerulus vasculature development [GO:0072012]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of positive chemotaxis [GO:0050928]; positive regulation of angiogenesis [GO:0045766]; response to activity [GO:0014823]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]; Tie signaling pathway [GO:0048014]	cell projection [GO:0042995]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	metal ion binding [GO:0046872]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]	cell projection [GO:0042995]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; metal ion binding [GO:0046872]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; cellular response to growth factor stimulus [GO:0071363]; gene expression [GO:0010467]; germ cell development [GO:0007281]; glomerulus vasculature development [GO:0072012]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of positive chemotaxis [GO:0050928]; positive regulation of angiogenesis [GO:0045766]; response to activity [GO:0014823]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]; Tie signaling pathway [GO:0048014]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32908006}.
O15126	reviewed	SCAM1_HUMAN	Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1)	SCAMP1 SCAMP	Homo sapiens (Human)	338	FUNCTION: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	endocytosis [GO:0006897]; establishment of localization in cell [GO:0051649]; exocytosis [GO:0006887]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]	clathrin-coated vesicle [GO:0030136]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; zymogen granule membrane [GO:0042589]	protein domain specific binding [GO:0019904]	clathrin-coated vesicle [GO:0030136]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; zymogen granule membrane [GO:0042589]; protein domain specific binding [GO:0019904]; endocytosis [GO:0006897]; establishment of localization in cell [GO:0051649]; exocytosis [GO:0006887]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15840657}; Multi-pass membrane protein {ECO:0000269|PubMed:15840657}. Recycling endosome membrane {ECO:0000269|PubMed:15840657}; Multi-pass membrane protein {ECO:0000269|PubMed:15840657}.
O15127	reviewed	SCAM2_HUMAN	Secretory carrier-associated membrane protein 2 (Secretory carrier membrane protein 2)	SCAMP2	Homo sapiens (Human)	329	FUNCTION: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.		post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]		extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15840657}; Multi-pass membrane protein {ECO:0000269|PubMed:15840657}. Recycling endosome membrane {ECO:0000269|PubMed:15840657}; Multi-pass membrane protein {ECO:0000269|PubMed:15840657}.
O15130	reviewed	NPFF_HUMAN	Pro-FMRFamide-related neuropeptide FF (FMRFamide-related peptides) [Cleaved into: Neuropeptide SF (NPSF); Neuropeptide FF (NPFF); Neuropeptide AF (NPAF)]	NPFF	Homo sapiens (Human)	113	FUNCTION: Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. {ECO:0000269|PubMed:11587714}.		chemical synaptic transmission [GO:0007268]; excitatory postsynaptic potential [GO:0060079]; neuropeptide signaling pathway [GO:0007218]	axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perikaryon [GO:0043204]; postsynapse [GO:0098794]	G protein-coupled receptor binding [GO:0001664]; neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102]	axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; G protein-coupled receptor binding [GO:0001664]; neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102]; chemical synaptic transmission [GO:0007268]; excitatory postsynaptic potential [GO:0060079]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Secreted.
O15131	reviewed	IMA6_HUMAN	Importin subunit alpha-6 (Karyopherin subunit alpha-5)	KPNA5	Homo sapiens (Human)	539	FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.		NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606]	cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]	cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Cytoplasm.
O15143	reviewed	ARC1B_HUMAN	Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC)	ARPC1B ARC41	Homo sapiens (Human)	372	FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.		Arp2/3 complex-mediated actin nucleation [GO:0034314]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; tubulobulbar complex [GO:0036284]	actin binding [GO:0003779]; protein-containing complex binding [GO:0044877]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; tubulobulbar complex [GO:0036284]; actin binding [GO:0003779]; protein-containing complex binding [GO:0044877]; structural constituent of cytoskeleton [GO:0005200]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:9230079}. Nucleus {ECO:0000269|PubMed:29925947}.
O15144	reviewed	ARPC2_HUMAN	Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)	ARPC2 ARC34 PRO2446	Homo sapiens (Human)	300	FUNCTION: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.		actin filament polymerization [GO:0030041]; actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; muscle cell projection membrane [GO:0036195]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	actin binding [GO:0003779]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; muscle cell projection membrane [GO:0036195]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; actin binding [GO:0003779]; structural constituent of cytoskeleton [GO:0005200]; actin filament polymerization [GO:0030041]; actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9230079}. Cell projection {ECO:0000269|PubMed:9230079}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q9CVB6}. Nucleus {ECO:0000269|PubMed:29925947}.
O15145	reviewed	ARPC3_HUMAN	Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)	ARPC3 ARC21	Homo sapiens (Human)	178	FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.		actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cellular response to nerve growth factor stimulus [GO:1990090]; regulation of actin filament polymerization [GO:0030833]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; growth cone leading edge [GO:0061850]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	actin binding [GO:0003779]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; growth cone leading edge [GO:0061850]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; actin binding [GO:0003779]; structural constituent of cytoskeleton [GO:0005200]; actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cellular response to nerve growth factor stimulus [GO:1990090]; regulation of actin filament polymerization [GO:0030833]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9230079, ECO:0000269|PubMed:9359840}. Cell projection {ECO:0000269|PubMed:9230079, ECO:0000269|PubMed:9359840}. Nucleus {ECO:0000269|PubMed:29925947}.
O15146	reviewed	MUSK_HUMAN	Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)	MUSK	Homo sapiens (Human)	869	FUNCTION: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:25537362}.		cell differentiation [GO:0030154]; memory [GO:0007613]; neuromuscular junction development [GO:0007528]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein geranylgeranylation [GO:2000541]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; Wnt-protein binding [GO:0017147]	neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; Wnt-protein binding [GO:0017147]; cell differentiation [GO:0030154]; memory [GO:0007613]; neuromuscular junction development [GO:0007528]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein geranylgeranylation [GO:2000541]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:23326516}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with acetylcholine receptors (AChR) to the postsynaptic cell membrane of the neuromuscular junction. {ECO:0000269|PubMed:23326516}.
O15151	reviewed	MDM4_HUMAN	Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)	MDM4 MDMX	Homo sapiens (Human)	490	FUNCTION: Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}.	MISCELLANEOUS: [Isoform HDMX211]: Cancer-specific isoform, may counteract MDM2/MDM4-mediated p53 degradation. {ECO:0000305}.	atrial septum development [GO:0003283]; atrioventricular valve morphogenesis [GO:0003181]; cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; endocardial cushion morphogenesis [GO:0003203]; heart valve development [GO:0003170]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; regulation of cell cycle [GO:0051726]; ventricular septum development [GO:0003281]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	enzyme binding [GO:0019899]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; enzyme binding [GO:0019899]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; atrial septum development [GO:0003283]; atrioventricular valve morphogenesis [GO:0003181]; cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; endocardial cushion morphogenesis [GO:0003203]; heart valve development [GO:0003170]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; regulation of cell cycle [GO:0051726]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Nucleus.
O15155	reviewed	BET1_HUMAN	BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18)	BET1	Homo sapiens (Human)	118	FUNCTION: Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). {ECO:0000250}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; vesicle fusion with Golgi apparatus [GO:0048280]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133]	SNAP receptor activity [GO:0005484]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133]; SNAP receptor activity [GO:0005484]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; vesicle fusion with Golgi apparatus [GO:0048280]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). {ECO:0000250}.
O15156	reviewed	ZBT7B_HUMAN	Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK)	ZBTB7B ZBTB15 ZFP67 ZNF857B	Homo sapiens (Human)	539	FUNCTION: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}.		adaptive thermogenesis [GO:1990845]; ectoderm development [GO:0007398]; lactation [GO:0007595]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of gene expression [GO:0010629]; negative regulation of NK T cell proliferation [GO:0051141]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of transcription by RNA polymerase II [GO:0000122]; NK T cell differentiation [GO:0001865]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of SREBP signaling pathway [GO:2000640]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; transcription by RNA polymerase II [GO:0006366]	nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; adaptive thermogenesis [GO:1990845]; ectoderm development [GO:0007398]; lactation [GO:0007595]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of gene expression [GO:0010629]; negative regulation of NK T cell proliferation [GO:0051141]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of transcription by RNA polymerase II [GO:0000122]; NK T cell differentiation [GO:0001865]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of SREBP signaling pathway [GO:2000640]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q64321}.
O15160	reviewed	RPAC1_HUMAN	DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40)	POLR1C POLR1E	Homo sapiens (Human)	346	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). {ECO:0000250|UniProtKB:P07703, ECO:0000305|PubMed:26151409}.		transcription by RNA polymerase I [GO:0006360]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]; RNA polymerase III complex [GO:0005666]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]; RNA polymerase I activity [GO:0001054]; RNA polymerase III activity [GO:0001056]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]; RNA polymerase I activity [GO:0001054]; RNA polymerase III activity [GO:0001056]; transcription by RNA polymerase I [GO:0006360]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26151409}.
O15162	reviewed	PLS1_HUMAN	Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (Mg(2+)-dependent nuclease) (EC 3.1.-.-) (MmTRA1b)	PLSCR1	Homo sapiens (Human)	318	FUNCTION: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:9218461, PubMed:8663431, PubMed:10770950, PubMed:9572851, PubMed:9485382, PubMed:18629440, PubMed:23590222, PubMed:24648509, PubMed:24343571, PubMed:32110987, PubMed:23659204, PubMed:29748552). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (PubMed:27206388, PubMed:17567603). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724). May contribute to cytokine-regulated cell proliferation and differentiation (By similarity). May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes (PubMed:15308695). Inhibits the functions of viral transactivators, including human T-cell leukemia virus (HTLV)-1 protein Tax, human immunodeficiency virus (HIV)-1 Tat, human hepatitis B virus (HBV) HBx, Epstein-Barr virus (EBV) BZLF1 and human cytomegalovirus IE1 and IE2 proteins through direct interactions (PubMed:22789739, PubMed:31434743, PubMed:25365352, PubMed:23501106, PubMed:35138119). Mediates also the inhibition of influenza virus infection by preventing nuclear import of the viral nucleoprotein/NP (PubMed:29352288, PubMed:35595813). Plays a crucial role as a defense factor against SARS-CoV-2 independently of its scramblase activity by directly targeting nascent viral vesicles to prevent virus-membrane fusion and the release of viral RNA into the host-cell cytosol (PubMed:37438530). {ECO:0000250|UniProtKB:Q9JJ00, ECO:0000269|PubMed:10770950, ECO:0000269|PubMed:15308695, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18629440, ECO:0000269|PubMed:21806988, ECO:0000269|PubMed:22789739, ECO:0000269|PubMed:23501106, ECO:0000269|PubMed:23590222, ECO:0000269|PubMed:23659204, ECO:0000269|PubMed:24343571, ECO:0000269|PubMed:24648509, ECO:0000269|PubMed:25365352, ECO:0000269|PubMed:26745724, ECO:0000269|PubMed:27206388, ECO:0000269|PubMed:29748552, ECO:0000269|PubMed:31434743, ECO:0000269|PubMed:32110987, ECO:0000269|PubMed:35138119, ECO:0000269|PubMed:37438530, ECO:0000269|PubMed:8663431, ECO:0000269|PubMed:9218461, ECO:0000269|PubMed:9485382, ECO:0000269|PubMed:9572851}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for HCV. {ECO:0000269|PubMed:21806988}.		acute-phase response [GO:0006953]; apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; negative regulation of phagocytosis [GO:0050765]; negative regulation of viral genome replication [GO:0045071]; phosphatidylserine biosynthetic process [GO:0006659]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]; plasma membrane phospholipid scrambling [GO:0017121]; platelet activation [GO:0030168]; positive regulation of chromosome separation [GO:1905820]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of gene expression [GO:0010628]; positive regulation of innate immune response [GO:0045089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; regulation of mast cell activation [GO:0033003]; response to interferon-beta [GO:0035456]; response to lead ion [GO:0010288]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; CD4 receptor binding [GO:0042609]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; enzyme binding [GO:0019899]; epidermal growth factor receptor binding [GO:0005154]; lead ion binding [GO:0032791]; magnesium ion binding [GO:0000287]; mercury ion binding [GO:0045340]; nuclease activity [GO:0004518]; phospholipid scramblase activity [GO:0017128]; SH3 domain binding [GO:0017124]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; CD4 receptor binding [GO:0042609]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; enzyme binding [GO:0019899]; epidermal growth factor receptor binding [GO:0005154]; lead ion binding [GO:0032791]; magnesium ion binding [GO:0000287]; mercury ion binding [GO:0045340]; nuclease activity [GO:0004518]; phospholipid scramblase activity [GO:0017128]; SH3 domain binding [GO:0017124]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]; acute-phase response [GO:0006953]; apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; negative regulation of phagocytosis [GO:0050765]; negative regulation of viral genome replication [GO:0045071]; phosphatidylserine biosynthetic process [GO:0006659]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]; plasma membrane phospholipid scrambling [GO:0017121]; platelet activation [GO:0030168]; positive regulation of chromosome separation [GO:1905820]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of gene expression [GO:0010628]; positive regulation of innate immune response [GO:0045089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; regulation of mast cell activation [GO:0033003]; response to interferon-beta [GO:0035456]; response to lead ion [GO:0010288]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12564925, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23590222, ECO:0000269|PubMed:24648509, ECO:0000269|PubMed:26745724, ECO:0000269|PubMed:37438530}; Single-pass type II membrane protein {ECO:0000269|PubMed:26745724}. Cell membrane {ECO:0000269|PubMed:12564925}; Lipid-anchor {ECO:0000305|PubMed:12564925}; Cytoplasmic side. Nucleus {ECO:0000269|PubMed:12564925, ECO:0000269|PubMed:16091359, ECO:0000269|PubMed:22789739, ECO:0000269|PubMed:23501106, ECO:0000269|PubMed:24648509, ECO:0000269|PubMed:35595813}. Cytoplasm {ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:22789739, ECO:0000269|PubMed:23501106, ECO:0000269|PubMed:29352288, ECO:0000269|PubMed:35595813}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:26745724}. Note=Localizes to the perinuclear region in the presence of RELT (PubMed:22052202). Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (PubMed:12564925). {ECO:0000269|PubMed:12564925, ECO:0000269|PubMed:22052202}.
O15164	reviewed	TIF1A_HUMAN	Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)	TRIM24 RNF82 TIF1 TIF1A	Homo sapiens (Human)	1050	FUNCTION: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Participates also in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}.		calcium ion homeostasis [GO:0055074]; cellular response to estrogen stimulus [GO:0071391]; epithelial cell proliferation [GO:0050673]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of gene expression [GO:0010628]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of vitamin D receptor signaling pathway [GO:0070562]; response to peptide hormone [GO:0043434]; transcription by RNA polymerase II [GO:0006366]	cytosol [GO:0005829]; euchromatin [GO:0000791]; male germ cell nucleus [GO:0001673]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]	chromatin binding [GO:0003682]; estrogen response element binding [GO:0034056]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; euchromatin [GO:0000791]; male germ cell nucleus [GO:0001673]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; chromatin binding [GO:0003682]; estrogen response element binding [GO:0034056]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; calcium ion homeostasis [GO:0055074]; cellular response to estrogen stimulus [GO:0071391]; epithelial cell proliferation [GO:0050673]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of gene expression [GO:0010628]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of vitamin D receptor signaling pathway [GO:0070562]; response to peptide hormone [GO:0043434]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:32324863}. Cytoplasm {ECO:0000269|PubMed:21164480}. Mitochondrion {ECO:0000269|PubMed:32324863}. Note=Colocalizes with sites of active transcription. Predominantly nuclear. Translocated from nucleus to mitochondria to mediate antiviral immunity (PubMed:32324863). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:32324863}.
O15165	reviewed	LRAD4_HUMAN	Low-density lipoprotein receptor class A domain-containing protein 4	LDLRAD4 C18orf1	Homo sapiens (Human)	306	FUNCTION: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. {ECO:0000269|PubMed:24627487}.		negative regulation of cell migration [GO:0030336]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	R-SMAD binding [GO:0070412]	early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; R-SMAD binding [GO:0070412]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:24627487}; Single-pass membrane protein {ECO:0000269|PubMed:24627487}.
O15169	reviewed	AXIN1_HUMAN	Axin-1 (Axis inhibition protein 1) (hAxin)	AXIN1 AXIN	Homo sapiens (Human)	862	FUNCTION: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}.		activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; axial mesoderm formation [GO:0048320]; canonical Wnt signaling pathway [GO:0060070]; cell development [GO:0048468]; cytoplasmic microtubule organization [GO:0031122]; dorsal/ventral axis specification [GO:0009950]; genomic imprinting [GO:0071514]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; nucleocytoplasmic transport [GO:0006913]; positive regulation of JNK cascade [GO:0046330]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; post-anal tail morphogenesis [GO:0036342]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein-containing complex assembly [GO:0065003]; sensory perception of sound [GO:0007605]	beta-catenin destruction complex [GO:0030877]; cell cortex [GO:0005938]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909]	armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein self-association [GO:0043621]; R-SMAD binding [GO:0070412]; signaling adaptor activity [GO:0035591]; SMAD binding [GO:0046332]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]	beta-catenin destruction complex [GO:0030877]; cell cortex [GO:0005938]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909]; armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein self-association [GO:0043621]; R-SMAD binding [GO:0070412]; signaling adaptor activity [GO:0035591]; SMAD binding [GO:0046332]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; axial mesoderm formation [GO:0048320]; canonical Wnt signaling pathway [GO:0060070]; cell development [GO:0048468]; cytoplasmic microtubule organization [GO:0031122]; dorsal/ventral axis specification [GO:0009950]; genomic imprinting [GO:0071514]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; nucleocytoplasmic transport [GO:0006913]; positive regulation of JNK cascade [GO:0046330]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; post-anal tail morphogenesis [GO:0036342]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein-containing complex assembly [GO:0065003]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16601693}. Nucleus {ECO:0000269|PubMed:17210684}. Membrane {ECO:0000250|UniProtKB:O35625}. Cell membrane {ECO:0000250|UniProtKB:O35625}. Note=MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX (PubMed:17210684). {ECO:0000250|UniProtKB:O35625, ECO:0000269|PubMed:17210684}.
O15173	reviewed	PGRC2_HUMAN	Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6)	PGRMC2 DG6 PMBP	Homo sapiens (Human)	223	FUNCTION: Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). {ECO:0000250|UniProtKB:Q80UU9, ECO:0000269|PubMed:28111073, ECO:0000305|PubMed:28396637}.	MISCELLANEOUS: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). {ECO:0000303|PubMed:28396637}.	adipose tissue development [GO:0060612]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear envelope [GO:0005635]	heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]; nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]; nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]; adipose tissue development [GO:0060612]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:23793472}; Single-pass membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000269|PubMed:27754849, ECO:0000269|PubMed:28111073}. Endoplasmic reticulum {ECO:0000269|PubMed:27754849}.
O15178	reviewed	TBXT_HUMAN	T-box transcription factor T (Brachyury protein) (Protein T)	TBXT T	Homo sapiens (Human)	435	FUNCTION: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site. {ECO:0000250|UniProtKB:P20293}.		anterior/posterior axis specification, embryo [GO:0008595]; cardiac muscle cell myoblast differentiation [GO:0060379]; cell fate specification [GO:0001708]; heart morphogenesis [GO:0003007]; mesoderm development [GO:0007498]; mesoderm formation [GO:0001707]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; somitogenesis [GO:0001756]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior axis specification, embryo [GO:0008595]; cardiac muscle cell myoblast differentiation [GO:0060379]; cell fate specification [GO:0001708]; heart morphogenesis [GO:0003007]; mesoderm development [GO:0007498]; mesoderm formation [GO:0001707]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22611028, ECO:0000269|PubMed:24253444}.
O15182	reviewed	CETN3_HUMAN	Centrin-3	CETN3 CEN3	Homo sapiens (Human)	167	FUNCTION: Plays a fundamental role in microtubule-organizing center structure and function.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000269|PubMed:22307388, ECO:0000305|PubMed:23591820}.		cell division [GO:0051301]; centrosome cycle [GO:0007098]; mRNA transport [GO:0051028]; protein transport [GO:0015031]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; nuclear pore nuclear basket [GO:0044615]; nucleolus [GO:0005730]; photoreceptor connecting cilium [GO:0032391]; transcription export complex 2 [GO:0070390]	calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; microtubule binding [GO:0008017]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; nuclear pore nuclear basket [GO:0044615]; nucleolus [GO:0005730]; photoreceptor connecting cilium [GO:0032391]; transcription export complex 2 [GO:0070390]; calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; microtubule binding [GO:0008017]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; mRNA transport [GO:0051028]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:9256449}. Nucleus, nucleolus {ECO:0000303|PubMed:22307388}. Nucleus envelope {ECO:0000269|PubMed:23591820}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:23591820}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:26337392}. Note=Centrosome of interphase and mitotic cells (PubMed:9256449). Localizes to centriole distal lumen (PubMed:26337392). Localization at the nuclear pore complex requires NUP153 and TPR (PubMed:23591820). {ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:26337392, ECO:0000269|PubMed:9256449}.
O15194	reviewed	CTDSL_HUMAN	CTD small phosphatase-like protein (CTDSP-like) (EC 3.1.3.16) (Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3) (NIF-like protein) (Nuclear LIM interactor-interacting factor 1) (NLI-interacting factor 1) (Protein YA22) (hYA22) (RBSP3) (Small C-terminal domain phosphatase 3) (SCP3) (Small CTD phosphatase 3)	CTDSPL C3orf8 NIF1 NIFL SCP3 YA22	Homo sapiens (Human)	276	FUNCTION: Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. {ECO:0000250, ECO:0000269|PubMed:12721286}.		negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of protein phosphorylation [GO:0001933]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of protein phosphorylation [GO:0001933]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
O15195	reviewed	VILL_HUMAN	Villin-like protein	VILL	Homo sapiens (Human)	856	FUNCTION: Possible tumor suppressor.		actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]	actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; structural constituent of cytoskeleton [GO:0005200]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]	
O15197	reviewed	EPHB6_HUMAN	Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6)	EPHB6	Homo sapiens (Human)	1021	FUNCTION: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. {ECO:0000269|PubMed:12517763, ECO:0000269|PubMed:15955811}.		axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]	cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003]; signaling receptor activity [GO:0038023]; transmembrane-ephrin receptor activity [GO:0005005]	cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003]; signaling receptor activity [GO:0038023]; transmembrane-ephrin receptor activity [GO:0005005]; axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.
O15198	reviewed	SMAD9_HUMAN	Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9)	SMAD9 MADH6 MADH9 SMAD8	Homo sapiens (Human)	467	FUNCTION: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).		anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; regulation of transcription by RNA polymerase II [GO:0006357]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMAD protein complex [GO:0071141]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMAD protein complex [GO:0071141]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; regulation of transcription by RNA polymerase II [GO:0006357]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity). {ECO:0000250}.
O15204	reviewed	ADEC1_HUMAN	ADAM DEC1 (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin-1) (ADAM-like protein decysin-1)	ADAMDEC1	Homo sapiens (Human)	470	FUNCTION: May play an important role in the control of the immune response and during pregnancy. {ECO:0000250}.		immune response [GO:0006955]; negative regulation of cell adhesion [GO:0007162]; proteolysis [GO:0006508]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; immune response [GO:0006955]; negative regulation of cell adhesion [GO:0007162]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
O15205	reviewed	UBD_HUMAN	Ubiquitin D (Diubiquitin) (Ubiquitin-like protein FAT10)	UBD FAT10	Homo sapiens (Human)	165	FUNCTION: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). {ECO:0000269|PubMed:15831455, ECO:0000269|PubMed:16495226, ECO:0000269|PubMed:16495380, ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:18574467, ECO:0000269|PubMed:19028597, ECO:0000269|PubMed:19033385, ECO:0000269|PubMed:19166848, ECO:0000269|PubMed:19726511, ECO:0000269|PubMed:19959714}.	MISCELLANEOUS: Common types of chronic kidney disease are associated with tubulointerstitial up-regulation of FAT10. FAT10 may mediate NF-kappa-B activation and may promote tubulointerstitial inflammation in chronic kidney diseases.	aggresome assembly [GO:0070842]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein modification by small protein conjugation [GO:0032446]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; ubiquitin-dependent protein catabolic process [GO:0006511]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	proteasome binding [GO:0070628]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome binding [GO:0070628]; aggresome assembly [GO:0070842]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein modification by small protein conjugation [GO:0032446]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12730673, ECO:0000269|PubMed:19033385}. Cytoplasm {ECO:0000250}. Note=Accumulates in aggresomes under proteasome inhibition conditions.
O15209	reviewed	ZBT22_HUMAN	Zinc finger and BTB domain-containing protein 22 (Protein BING1) (Zinc finger and BTB domain-containing protein 22A) (Zinc finger protein 297)	ZBTB22 BING1 ZBTB22A ZNF297	Homo sapiens (Human)	634	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O15211	reviewed	RGL2_HUMAN	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L)	RGL2 RAB2L	Homo sapiens (Human)	777	FUNCTION: Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}.		negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; Ras protein signal transduction [GO:0007265]; regulation of Ral protein signal transduction [GO:0032485]	cytosol [GO:0005829]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; guanyl-nucleotide exchange factor activity [GO:0005085]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; Ras protein signal transduction [GO:0007265]; regulation of Ral protein signal transduction [GO:0032485]	
O15212	reviewed	PFD6_HUMAN	Prefoldin subunit 6 (Protein Ke2)	PFDN6 HKE2 PFD6	Homo sapiens (Human)	129	FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.		chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	cytoplasm [GO:0005737]; prefoldin complex [GO:0016272]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]	amyloid-beta binding [GO:0001540]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; prefoldin complex [GO:0016272]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; amyloid-beta binding [GO:0001540]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	
O15213	reviewed	WDR46_HUMAN	WD repeat-containing protein 46 (WD repeat-containing protein BING4)	WDR46 BING4 C6orf11 FP221	Homo sapiens (Human)	610	FUNCTION: Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus (PubMed:23848194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23848194, ECO:0000269|PubMed:34516797}.		maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:23848194, ECO:0000269|PubMed:34516797}.
O15217	reviewed	GSTA4_HUMAN	Glutathione S-transferase A4 (EC 2.5.1.18) (GST class-alpha member 4) (Glutathione S-transferase A4-4)	GSTA4	Homo sapiens (Human)	222	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE). {ECO:0000269|PubMed:10329152, ECO:0000269|PubMed:20085333}.		glutathione metabolic process [GO:0006749]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]	glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; glutathione metabolic process [GO:0006749]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm.
O15226	reviewed	NKRF_HUMAN	NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4)	NKRF ITBA4 NRF	Homo sapiens (Human)	690	FUNCTION: Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}.		negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATPase activator activity [GO:0001671]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATPase activator activity [GO:0001671]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
O15228	reviewed	GNPAT_HUMAN	Dihydroxyacetone phosphate acyltransferase (DAP-AT) (DHAP-AT) (EC 2.3.1.42) (Acyl-CoA:dihydroxyacetonephosphateacyltransferase) (Glycerone-phosphate O-acyltransferase)	GNPAT DAPAT DHAPAT	Homo sapiens (Human)	680	FUNCTION: Dihydroxyacetonephosphate acyltransferase involved in plasmalogen biosynthesis. {ECO:0000269|PubMed:15687349}.		cerebellum morphogenesis [GO:0021587]; ether lipid biosynthetic process [GO:0008611]; fatty acid metabolic process [GO:0006631]; membrane organization [GO:0061024]; paranodal junction assembly [GO:0030913]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]; response to fatty acid [GO:0070542]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416]; triglyceride biosynthetic process [GO:0019432]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; glycerone-phosphate O-acyltransferase activity [GO:0016287]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; glycerone-phosphate O-acyltransferase activity [GO:0016287]; cerebellum morphogenesis [GO:0021587]; ether lipid biosynthetic process [GO:0008611]; fatty acid metabolic process [GO:0006631]; membrane organization [GO:0061024]; paranodal junction assembly [GO:0030913]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]; response to fatty acid [GO:0070542]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:Q9ES71}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9ES71}; Matrix side {ECO:0000250|UniProtKB:Q9ES71}. Note=Exclusively localized to the lumenal side of the peroxisomal membrane. {ECO:0000250, ECO:0000250|UniProtKB:Q9ES71}.
O15229	reviewed	KMO_HUMAN	Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase)	KMO	Homo sapiens (Human)	486	FUNCTION: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). {ECO:0000269|PubMed:23575632, ECO:0000269|PubMed:26752518, ECO:0000269|PubMed:28604669, ECO:0000269|PubMed:29208702, ECO:0000269|PubMed:29429898, ECO:0000305|PubMed:12402501}.	MISCELLANEOUS: Increased in neuroinflammatory conditions. Inhibitors are investigated as potential neuroprotective drugs since they lead to an increased level of kynurenic acid, a neuroprotective NMDA receptor agonist. {ECO:0000269|PubMed:9237672}.; MISCELLANEOUS: [Isoform 3]: Gene model based on mouse cDNA data. {ECO:0000305}.	'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; kynurenic acid biosynthetic process [GO:0034276]; kynurenine metabolic process [GO:0070189]; L-kynurenine metabolic process [GO:0097052]; NAD metabolic process [GO:0019674]; positive regulation of glutamate secretion, neurotransmission [GO:1903296]; quinolinate biosynthetic process [GO:0019805]; response to salt stress [GO:0009651]; tryptophan catabolic process [GO:0006569]	cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]	FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; kynurenine 3-monooxygenase activity [GO:0004502]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]	cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; kynurenine 3-monooxygenase activity [GO:0004502]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; kynurenic acid biosynthetic process [GO:0034276]; kynurenine metabolic process [GO:0070189]; L-kynurenine metabolic process [GO:0097052]; NAD metabolic process [GO:0019674]; positive regulation of glutamate secretion, neurotransmission [GO:1903296]; quinolinate biosynthetic process [GO:0019805]; response to salt stress [GO:0009651]; tryptophan catabolic process [GO:0006569]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}.
O15230	reviewed	LAMA5_HUMAN	Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha)	LAMA5 KIAA0533 KIAA1907	Homo sapiens (Human)	3695	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signaling and PTK2B/PYK2 (PubMed:33242826). {ECO:0000269|PubMed:33242826}.		branching involved in salivary gland morphogenesis [GO:0060445]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell migration [GO:0016477]; cilium assembly [GO:0060271]; hair follicle development [GO:0001942]; integrin-mediated signaling pathway [GO:0007229]; lung development [GO:0030324]; morphogenesis of a polarized epithelium [GO:0001738]; morphogenesis of embryonic epithelium [GO:0016331]; muscle organ development [GO:0007517]; odontogenesis of dentin-containing tooth [GO:0042475]; postsynapse organization [GO:0099173]; protein localization to plasma membrane [GO:0072659]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; regulation of epithelial cell proliferation [GO:0050678]; skeletal system morphogenesis [GO:0048705]; substrate adhesion-dependent cell spreading [GO:0034446]; trunk neural crest cell migration [GO:0036484]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix of synaptic cleft [GO:0098965]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; laminin-10 complex [GO:0043259]; laminin-11 complex [GO:0043260]; laminin-5 complex [GO:0005610]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; synaptic cleft [GO:0043083]	integrin binding [GO:0005178]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix of synaptic cleft [GO:0098965]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; laminin-10 complex [GO:0043259]; laminin-11 complex [GO:0043260]; laminin-5 complex [GO:0005610]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; synaptic cleft [GO:0043083]; integrin binding [GO:0005178]; branching involved in salivary gland morphogenesis [GO:0060445]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell migration [GO:0016477]; cilium assembly [GO:0060271]; hair follicle development [GO:0001942]; integrin-mediated signaling pathway [GO:0007229]; lung development [GO:0030324]; morphogenesis of a polarized epithelium [GO:0001738]; morphogenesis of embryonic epithelium [GO:0016331]; muscle organ development [GO:0007517]; odontogenesis of dentin-containing tooth [GO:0042475]; postsynapse organization [GO:0099173]; protein localization to plasma membrane [GO:0072659]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; regulation of epithelial cell proliferation [GO:0050678]; skeletal system morphogenesis [GO:0048705]; substrate adhesion-dependent cell spreading [GO:0034446]; trunk neural crest cell migration [GO:0036484]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
O15231	reviewed	ZN185_HUMAN	Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A)	ZNF185	Homo sapiens (Human)	689	FUNCTION: May be involved in the regulation of cellular proliferation and/or differentiation.			cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]	zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16799630}. Cell junction, focal adhesion {ECO:0000269|PubMed:16799630}.
O15232	reviewed	MATN3_HUMAN	Matrilin-3	MATN3	Homo sapiens (Human)	486	FUNCTION: Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.		cartilage development [GO:0051216]; extracellular matrix organization [GO:0030198]; skeletal system development [GO:0001501]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; cartilage development [GO:0051216]; extracellular matrix organization [GO:0030198]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O35701}.
O15234	reviewed	CASC3_HUMAN	Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)	CASC3 MLN51	Homo sapiens (Human)	703	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}.		intracellular mRNA localization [GO:0008298]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation [GO:0006417]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; U2-type catalytic step 1 spliceosome [GO:0071006]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; U2-type catalytic step 1 spliceosome [GO:0071006]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; intracellular mRNA localization [GO:0008298]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation [GO:0006417]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12080473}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8K3W3}. Nucleus {ECO:0000269|PubMed:12080473, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. Nucleus speckle {ECO:0000269|PubMed:16170325}. Cytoplasm, Stress granule {ECO:0000269|PubMed:17652158}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q8K3X0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8K3X0}. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:15166247). In nuclear speckles, colocalizes with MAGOH. Under stress conditions, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules (PubMed:17652158). In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (By similarity). {ECO:0000250|UniProtKB:Q8K3X0, ECO:0000269|PubMed:15166247, ECO:0000269|PubMed:17652158}.
O15239	reviewed	NDUA1_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (Complex I-MWFE) (CI-MWFE) (NADH-ubiquinone oxidoreductase MWFE subunit)	NDUFA1	Homo sapiens (Human)	70	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
O15240	reviewed	VGF_HUMAN	Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]]	VGF	Homo sapiens (Human)	615	FUNCTION: [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [Neuroendocrine regulatory peptide-2]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity). {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [VGF-derived peptide TLQP-21]: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [VGF-derived peptide TLQP-62]: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity). {ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Antimicrobial peptide VGF[554-577]]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris. {ECO:0000269|PubMed:23250050}.		carbohydrate homeostasis [GO:0033500]; defense response to bacterium [GO:0042742]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; ovarian follicle development [GO:0001541]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to cAMP [GO:0051591]; response to cold [GO:0009409]; response to dietary excess [GO:0002021]; response to insulin [GO:0032868]; sexual reproduction [GO:0019953]; synaptic signaling via neuropeptide [GO:0099538]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; transport vesicle [GO:0030133]	growth factor activity [GO:0008083]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; transport vesicle [GO:0030133]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; carbohydrate homeostasis [GO:0033500]; defense response to bacterium [GO:0042742]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; ovarian follicle development [GO:0001541]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to cAMP [GO:0051591]; response to cold [GO:0009409]; response to dietary excess [GO:0002021]; response to insulin [GO:0032868]; sexual reproduction [GO:0019953]; synaptic signaling via neuropeptide [GO:0099538]	SUBCELLULAR LOCATION: [Neurosecretory protein VGF]: Secreted {ECO:0000269|PubMed:19194657}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:19194657}. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.
O15243	reviewed	OBRG_HUMAN	Leptin receptor gene-related protein (Endospanin-1) (Leptin receptor overlapping transcript protein) (OB-R gene-related protein) (OB-RGRP)	LEPROT LEPR OBR	Homo sapiens (Human)	131	FUNCTION: Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269|PubMed:18042720, ECO:0000269|PubMed:19907080}.		late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; positive regulation of protein targeting to mitochondrion [GO:1903955]	endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	signaling receptor binding [GO:0005102]	endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; signaling receptor binding [GO:0005102]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; positive regulation of protein targeting to mitochondrion [GO:1903955]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
O15244	reviewed	S22A2_HUMAN	Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2)	SLC22A2 OCT2	Homo sapiens (Human)	555	FUNCTION: Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:9260930, PubMed:9687576). Functions as a Na(+)-independent, bidirectional uniporter (PubMed:9687576, PubMed:21128598). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:9260930, PubMed:9687576, PubMed:15212162). However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (By similarity). Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (PubMed:15783073). Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters (PubMed:9687576, PubMed:16581093, PubMed:17460754). Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system (PubMed:17460754). Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium (PubMed:15817714). Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1-methylnicotinamide (NMN) (PubMed:9260930, PubMed:12089365, PubMed:15212162, PubMed:17072098, PubMed:24961373). Mediates the uptake and efflux of quaternary ammonium compound choline (PubMed:9260930). Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamines putrescine and spermidine (PubMed:12538837, PubMed:21128598). Able to transport non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (PubMed:11907186). Also involved in the uptake of xenobiotic 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (PubMed:12395288, PubMed:16394027). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000250|UniProtKB:Q9R0W2, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:12089365, ECO:0000269|PubMed:12395288, ECO:0000269|PubMed:12538837, ECO:0000269|PubMed:15212162, ECO:0000269|PubMed:15783073, ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:16394027, ECO:0000269|PubMed:16581093, ECO:0000269|PubMed:17072098, ECO:0000269|PubMed:17460754, ECO:0000269|PubMed:21128598, ECO:0000269|PubMed:24961373, ECO:0000269|PubMed:9260930, ECO:0000269|PubMed:9687576, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 2]: In contrast with isoform 1, not able to transport guanidine, creatinine, cimetidine and metformin. {ECO:0000269|PubMed:12089365, ECO:0000269|PubMed:15212162, ECO:0000269|PubMed:16272756}.	MISCELLANEOUS: Mediates the renal secretion of many clinically used cationic drugs (PubMed:12089365, PubMed:16272756). Transports drugs such as diabetes treatment medicine metformin, 1-methyl-4-phenylpyridinium (MPP(+)), famotidine, ranitidine, amantadine, acriflavine, amiloride, memantine, cimetidine, platinum-based drugs cisplatin and oxaliplatin, 3'-azido-3'-deoxythymidine (AZT) and tetraethylammonium (TEA) (PubMed:9260930, PubMed:12089365, PubMed:15496291, PubMed:16314463, PubMed:16272756, PubMed:16006492, PubMed:15783073, PubMed:16394027, PubMed:16951202, PubMed:16914559, PubMed:16581093, PubMed:24961373). Mediates the bidirectional transport of MPP(+) (PubMed:9260930, PubMed:12089365, PubMed:9687576). Metformin competitively inhibits OCT1-mediated thiamine uptake, leading to a decrease in hepatic steatosis (PubMed:24961373). Plays a predominant role in the anticancer activity of cisplatin and oxaliplatin and may contribute to antitumor specificity (PubMed:16951202, PubMed:16914559). Involved in cisplatin-induced nephrotoxicity (By similarity). {ECO:0000250|UniProtKB:Q9R0W2, ECO:0000269|PubMed:12089365, ECO:0000269|PubMed:15496291, ECO:0000269|PubMed:15783073, ECO:0000269|PubMed:16006492, ECO:0000269|PubMed:16272756, ECO:0000269|PubMed:16314463, ECO:0000269|PubMed:16394027, ECO:0000269|PubMed:16581093, ECO:0000269|PubMed:16914559, ECO:0000269|PubMed:16951202, ECO:0000269|PubMed:24961373, ECO:0000269|PubMed:9260930, ECO:0000269|PubMed:9687576, ECO:0000303|PubMed:12089365, ECO:0000303|PubMed:16272756}.	acetylcholine transport [GO:0015870]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; amine transport [GO:0015837]; amino acid import across plasma membrane [GO:0089718]; body fluid secretion [GO:0007589]; choline transport [GO:0015871]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; export across plasma membrane [GO:0140115]; histamine transport [GO:0051608]; histamine uptake [GO:0051615]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-arginine import across plasma membrane [GO:0097638]; monoatomic cation transport [GO:0006812]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; organic cation transport [GO:0015695]; positive regulation of gene expression [GO:0010628]; prostaglandin transport [GO:0015732]; purine-containing compound transmembrane transport [GO:0072530]; putrescine transport [GO:0015847]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; thiamine transmembrane transport [GO:0071934]; toxin transport [GO:1901998]; transport across blood-brain barrier [GO:0150104]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	acetylcholine transmembrane transporter activity [GO:0005277]; amine transmembrane transporter activity [GO:0005275]; choline transmembrane transporter activity [GO:0015220]; efflux transmembrane transporter activity [GO:0015562]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; prostaglandin transmembrane transporter activity [GO:0015132]; putrescine transmembrane transporter activity [GO:0015489]; pyrimidine nucleoside transmembrane transporter activity [GO:0015214]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; spermidine transmembrane transporter activity [GO:0015606]; thiamine transmembrane transporter activity [GO:0015234]; toxin transmembrane transporter activity [GO:0019534]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; acetylcholine transmembrane transporter activity [GO:0005277]; amine transmembrane transporter activity [GO:0005275]; choline transmembrane transporter activity [GO:0015220]; efflux transmembrane transporter activity [GO:0015562]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; prostaglandin transmembrane transporter activity [GO:0015132]; putrescine transmembrane transporter activity [GO:0015489]; pyrimidine nucleoside transmembrane transporter activity [GO:0015214]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; spermidine transmembrane transporter activity [GO:0015606]; thiamine transmembrane transporter activity [GO:0015234]; toxin transmembrane transporter activity [GO:0019534]; xenobiotic transmembrane transporter activity [GO:0042910]; acetylcholine transport [GO:0015870]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; amine transport [GO:0015837]; amino acid import across plasma membrane [GO:0089718]; body fluid secretion [GO:0007589]; choline transport [GO:0015871]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; export across plasma membrane [GO:0140115]; histamine transport [GO:0051608]; histamine uptake [GO:0051615]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-arginine import across plasma membrane [GO:0097638]; monoatomic cation transport [GO:0006812]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; organic cation transport [GO:0015695]; positive regulation of gene expression [GO:0010628]; prostaglandin transport [GO:0015732]; purine-containing compound transmembrane transport [GO:0072530]; putrescine transport [GO:0015847]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; thiamine transmembrane transport [GO:0071934]; toxin transport [GO:1901998]; transport across blood-brain barrier [GO:0150104]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9R0W2}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:9260930}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basal membrane of Sertoli cells (PubMed:35307651). Localized to the basolateral membrane of proximal tubule (PubMed:11912245). Localized to the luminal/apical membrane of distal tubule (PubMed:9260930). Localized to the luminal/apical membrane of ciliated epithelial cells in bronchi (PubMed:15817714). {ECO:0000269|PubMed:11912245, ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:35307651, ECO:0000269|PubMed:9260930}.
O15245	reviewed	S22A1_HUMAN	Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1)	SLC22A1 OCT1	Homo sapiens (Human)	554	FUNCTION: Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:9260930, PubMed:9187257, PubMed:11388889, PubMed:9655880, PubMed:11408531, PubMed:15389554, PubMed:16263091, PubMed:16272756, PubMed:16581093, PubMed:19536068, PubMed:21128598, PubMed:23680637, PubMed:24961373, PubMed:34040533, PubMed:12439218, PubMed:12719534). Functions as a pH- and Na(+)-independent, bidirectional transporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential (i.e. membrane potential and concentration gradient) and substrate selectivity (By similarity). Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (By similarity). Primarily expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (By similarity). Most likely functions as an uptake carrier in enterocytes contributing to the intestinal elimination of organic cations from the systemic circulation (PubMed:16263091). Transports endogenous monoamines such as N-1-methylnicotinamide (NMN), guanidine, histamine, neurotransmitters dopamine, serotonin and adrenaline (PubMed:9260930, PubMed:24961373, PubMed:35469921, PubMed:12439218). Also transports natural polyamines such as spermidine, agmatine and putrescine at low affinity, but relatively high turnover (PubMed:21128598). Involved in the hepatic uptake of vitamin B1/thiamine, hence regulating hepatic lipid and energy metabolism (PubMed:24961373). Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium (PubMed:15817714). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with lower efficency (PubMed:17460754). Also capable of transporting non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (PubMed:11907186). May contribute to the transport of cationic compounds in testes across the blood-testis-barrier (Probable). Also involved in the uptake of xenobiotics tributylmethylammonium (TBuMA), quinidine, N-methyl-quinine (NMQ), N-methyl-quinidine (NMQD) N-(4,4-azo-n-pentyl)-quinuclidine (APQ), azidoprocainamide methoiodide (AMP), N-(4,4-azo-n-pentyl)-21-deoxyajmalinium (APDA) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (PubMed:9260930, PubMed:11408531, PubMed:15389554, PubMed:35469921). {ECO:0000250|UniProtKB:O08966, ECO:0000250|UniProtKB:Q63089, ECO:0000269|PubMed:11388889, ECO:0000269|PubMed:11408531, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:12439218, ECO:0000269|PubMed:12719534, ECO:0000269|PubMed:15389554, ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:16263091, ECO:0000269|PubMed:16272756, ECO:0000269|PubMed:16581093, ECO:0000269|PubMed:17460754, ECO:0000269|PubMed:19536068, ECO:0000269|PubMed:21128598, ECO:0000269|PubMed:23680637, ECO:0000269|PubMed:24961373, ECO:0000269|PubMed:34040533, ECO:0000269|PubMed:35469921, ECO:0000269|PubMed:9187257, ECO:0000269|PubMed:9260930, ECO:0000269|PubMed:9655880, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 1]: Mediates the uptake of 1-methyl-4-phenylpyridinium (MPP(+)). {ECO:0000269|PubMed:11388889}.; FUNCTION: [Isoform 2]: Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+)). {ECO:0000269|PubMed:11388889}.; FUNCTION: [Isoform 3]: Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+)). {ECO:0000269|PubMed:11388889}.; FUNCTION: [Isoform 4]: Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+)). {ECO:0000269|PubMed:11388889}.	MISCELLANEOUS: Involved in the uptake of clinically used drugs including diabetes treatment medicine metformin, neurotoxins 1-methyl-4-phenylpyridinium (MPP(+)) and iobenguane and platinum-based drug cisplatin (PubMed:9260930, PubMed:9187257, PubMed:11388889, PubMed:9655880, PubMed:16263091, PubMed:16272756, PubMed:16951202, PubMed:16914559, PubMed:16581093, PubMed:19536068, PubMed:23680637, PubMed:24961373, PubMed:35469921, PubMed:12439218, PubMed:12719534). Also involved in metformin efflux transport (PubMed:34040533). Metformin competitively inhibits OCT1-mediated thiamine uptake, leading to a decrease in hepatic steatosis (PubMed:24961373). Plays a role in the anticancer activity of cisplatin and may contribute to antitumor specificity (PubMed:16951202, PubMed:16914559). {ECO:0000269|PubMed:11388889, ECO:0000269|PubMed:12439218, ECO:0000269|PubMed:12719534, ECO:0000269|PubMed:16263091, ECO:0000269|PubMed:16272756, ECO:0000269|PubMed:16581093, ECO:0000269|PubMed:16914559, ECO:0000269|PubMed:16951202, ECO:0000269|PubMed:19536068, ECO:0000269|PubMed:23680637, ECO:0000269|PubMed:24961373, ECO:0000269|PubMed:34040533, ECO:0000269|PubMed:35469921, ECO:0000269|PubMed:9187257, ECO:0000269|PubMed:9260930, ECO:0000269|PubMed:9655880}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	acetylcholine transport [GO:0015870]; acyl carnitine transmembrane transport [GO:1902616]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; metanephric proximal tubule development [GO:0072237]; monoamine transport [GO:0015844]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; organic cation transport [GO:0015695]; prostaglandin transport [GO:0015732]; purine-containing compound transmembrane transport [GO:0072530]; putrescine transport [GO:0015847]; quaternary ammonium group transport [GO:0015697]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; thiamine transmembrane transport [GO:0071934]; thiamine transport [GO:0015888]; toxin transport [GO:1901998]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	(R)-carnitine transmembrane transporter activity [GO:1901235]; acetylcholine transmembrane transporter activity [GO:0005277]; dopamine:sodium symporter activity [GO:0005330]; identical protein binding [GO:0042802]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; norepinephrine:sodium symporter activity [GO:0005334]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; prostaglandin transmembrane transporter activity [GO:0015132]; putrescine transmembrane transporter activity [GO:0015489]; pyrimidine nucleoside transmembrane transporter activity [GO:0015214]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; secondary active organic cation transmembrane transporter activity [GO:0008513]; spermidine transmembrane transporter activity [GO:0015606]; thiamine transmembrane transporter activity [GO:0015234]; toxin transmembrane transporter activity [GO:0019534]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; (R)-carnitine transmembrane transporter activity [GO:1901235]; acetylcholine transmembrane transporter activity [GO:0005277]; dopamine:sodium symporter activity [GO:0005330]; identical protein binding [GO:0042802]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; norepinephrine:sodium symporter activity [GO:0005334]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; prostaglandin transmembrane transporter activity [GO:0015132]; putrescine transmembrane transporter activity [GO:0015489]; pyrimidine nucleoside transmembrane transporter activity [GO:0015214]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; secondary active organic cation transmembrane transporter activity [GO:0008513]; spermidine transmembrane transporter activity [GO:0015606]; thiamine transmembrane transporter activity [GO:0015234]; toxin transmembrane transporter activity [GO:0019534]; xenobiotic transmembrane transporter activity [GO:0042910]; acetylcholine transport [GO:0015870]; acyl carnitine transmembrane transport [GO:1902616]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; metanephric proximal tubule development [GO:0072237]; monoamine transport [GO:0015844]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; organic cation transport [GO:0015695]; prostaglandin transport [GO:0015732]; purine-containing compound transmembrane transport [GO:0072530]; putrescine transport [GO:0015847]; quaternary ammonium group transport [GO:0015697]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; thiamine transmembrane transport [GO:0071934]; thiamine transport [GO:0015888]; toxin transport [GO:1901998]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12719534}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:19536068, ECO:0000269|PubMed:23680637}; Multi-pass membrane protein {ECO:0000305}. Lateral cell membrane {ECO:0000269|PubMed:16263091}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:35469921}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the sinusoidal/basolateral membrane of hepatocytes (By similarity). Mainly localized to the basolateral membrane of renal proximal tubular cells (By similarity). However, also identified at the apical side of proximal tubular cells (PubMed:19536068). Mainly expressed at the lateral membrane of enterocytes (PubMed:16263091). Also observed at the apical side of enterocytes (PubMed:23680637). Localized to the luminal/apical membrane of ciliated epithelial cells in bronchi (PubMed:15817714). Localized to the basal membrane of Sertoli cells (PubMed:35307651). {ECO:0000250|UniProtKB:Q63089, ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:16263091, ECO:0000269|PubMed:19536068, ECO:0000269|PubMed:23680637, ECO:0000269|PubMed:35307651}.
O15247	reviewed	CLIC2_HUMAN	Chloride intracellular channel protein 2 (XAP121)	CLIC2	Homo sapiens (Human)	247	FUNCTION: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. {ECO:0000269|PubMed:15147738, ECO:0000269|PubMed:15916532, ECO:0000269|PubMed:17945253}.		chloride transport [GO:0006821]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of binding [GO:0051099]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; signal transduction [GO:0007165]	chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]; glutathione peroxidase activity [GO:0004602]; voltage-gated monoatomic ion channel activity [GO:0005244]	chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; glutathione peroxidase activity [GO:0004602]; voltage-gated monoatomic ion channel activity [GO:0005244]; chloride transport [GO:0006821]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of binding [GO:0051099]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15916532}. Membrane {ECO:0000305|PubMed:15916532}; Single-pass membrane protein {ECO:0000305|PubMed:15916532}. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
O15254	reviewed	ACOX3_HUMAN	Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase)	ACOX3 BRCOX PRCOX	Homo sapiens (Human)	700	FUNCTION: Oxidizes the CoA-esters of 2-methyl-branched fatty acids. {ECO:0000250|UniProtKB:Q63448}.		fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; lipid homeostasis [GO:0055088]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; pristanoyl-CoA oxidase activity [GO:0016402]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; pristanoyl-CoA oxidase activity [GO:0016402]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; lipid homeostasis [GO:0055088]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000305}.
O15258	reviewed	RER1_HUMAN	Protein RER1	RER1	Homo sapiens (Human)	196	FUNCTION: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. {ECO:0000250}.		positive regulation of protein localization to plasma membrane [GO:1903078]; protein retention in ER lumen [GO:0006621]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	acetylcholine receptor binding [GO:0033130]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; acetylcholine receptor binding [GO:0033130]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein retention in ER lumen [GO:0006621]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein.
O15259	reviewed	NPHP1_HUMAN	Nephrocystin-1 (Juvenile nephronophthisis 1 protein)	NPHP1 NPH1	Homo sapiens (Human)	732	FUNCTION: Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development (By similarity). In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q9QY53}.	MISCELLANEOUS: Nephronophthisis type 1 patients deficient for NPHP1 show normal overall integrity of respiratory cilia.	actin cytoskeleton organization [GO:0030036]; cell projection organization [GO:0030030]; cell-cell adhesion [GO:0098609]; positive regulation of bicellular tight junction assembly [GO:1903348]; protein localization involved in establishment of planar polarity [GO:0090251]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; spermatid differentiation [GO:0048515]; visual behavior [GO:0007632]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; motile cilium [GO:0031514]; photoreceptor connecting cilium [GO:0032391]	structural molecule activity [GO:0005198]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; motile cilium [GO:0031514]; photoreceptor connecting cilium [GO:0032391]; structural molecule activity [GO:0005198]; actin cytoskeleton organization [GO:0030036]; cell projection organization [GO:0030030]; cell-cell adhesion [GO:0098609]; positive regulation of bicellular tight junction assembly [GO:1903348]; protein localization involved in establishment of planar polarity [GO:0090251]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; spermatid differentiation [GO:0048515]; visual behavior [GO:0007632]	SUBCELLULAR LOCATION: Cell junction {ECO:0000250|UniProtKB:Q9QY53}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9QY53}. Cell projection, cilium {ECO:0000269|PubMed:16885411}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:16308564, ECO:0000269|PubMed:16885411}. Cell junction, tight junction. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium (By similarity). Colocalizes with E-cadherin and BCAR1 at or near the cell-cell adherens junctions (By similarity). Localized to respiratory cilia axoneme (PubMed:16308564, PubMed:16885411). Localized to the transition zone of respiratory cilia (PubMed:16885411). Localized to the transition zone of photoreceptor-connecting cilia and renal monocilia (By similarity). In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates at basolateral tight junctions (By similarity). {ECO:0000250|UniProtKB:Q9QY53, ECO:0000269|PubMed:16308564, ECO:0000269|PubMed:16885411}.
O15260	reviewed	SURF4_HUMAN	Surfeit locus protein 4	SURF4 SURF-4	Homo sapiens (Human)	269	FUNCTION: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed:30251625, PubMed:29643117, PubMed:33186557). Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed:29643117, PubMed:33186557). Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins (PubMed:33186557). Promotes the secretion of PCSK9 (PubMed:30251625). Also mediates the efficient secretion of erythropoietin (EPO) (PubMed:32989016). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi (PubMed:18287528). {ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:29643117, ECO:0000269|PubMed:30251625, ECO:0000269|PubMed:32989016, ECO:0000269|PubMed:33186557}.		Golgi organization [GO:0007030]; lipid homeostasis [GO:0055088]; lipoprotein transport [GO:0042953]; positive regulation of organelle organization [GO:0010638]; regulation of lipid transport [GO:0032368]	azurophil granule membrane [GO:0035577]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]	cargo receptor activity [GO:0038024]	azurophil granule membrane [GO:0035577]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; cargo receptor activity [GO:0038024]; Golgi organization [GO:0007030]; lipid homeostasis [GO:0055088]; lipoprotein transport [GO:0042953]; positive regulation of organelle organization [GO:0010638]; regulation of lipid transport [GO:0032368]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15308636, ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:30251625, ECO:0000269|PubMed:33186557}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:18287528}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:30251625, ECO:0000269|PubMed:33186557}; Multi-pass membrane protein {ECO:0000255}. Note=Cycles between the endoplasmic reticulum and the Golgi. {ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:33186557}.
O15263	reviewed	DFB4A_HUMAN	Defensin beta 4A (Beta-defensin 2) (BD-2) (hBD-2) (Defensin, beta 2) (Skin-antimicrobial peptide 1) (SAP1)	DEFB4A DEFB102 DEFB2 DEFB4; DEFB4B	Homo sapiens (Human)	64	FUNCTION: Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria (PubMed:9202117, PubMed:10837369). Antimicrobial activity against P.aruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM (PubMed:10837369). Also exhibits antimicrobial activity against the yeast C.albicans (PubMed:9202117, PubMed:10837369, PubMed:30050988). Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death (PubMed:30050988). Acts as a ligand for C-C chemokine receptor CCR6 (PubMed:10521347, PubMed:20068036). Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells, such as immature dendritic cells and memory T cells (PubMed:10521347, PubMed:20068036). {ECO:0000269|PubMed:10521347, ECO:0000269|PubMed:10837369, ECO:0000269|PubMed:20068036, ECO:0000269|PubMed:30050988, ECO:0000269|PubMed:9202117}.		antifungal innate immune response [GO:0061760]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; killing of cells of another organism [GO:0031640]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]	CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; antifungal innate immune response [GO:0061760]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; killing of cells of another organism [GO:0031640]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10837369}.
O15264	reviewed	MK13_HUMAN	Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)	MAPK13 PRKM13 SAPK4	Homo sapiens (Human)	365	FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. {ECO:0000269|PubMed:11500363, ECO:0000269|PubMed:11943212, ECO:0000269|PubMed:15632108, ECO:0000269|PubMed:17256148, ECO:0000269|PubMed:18006338, ECO:0000269|PubMed:18367666, ECO:0000269|PubMed:20478268, ECO:0000269|PubMed:9731215}.		cell cycle [GO:0007049]; cellular response to anisomycin [GO:0072740]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to sodium arsenite [GO:1903936]; cellular response to sorbitol [GO:0072709]; cellular response to UV [GO:0034644]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; response to osmotic stress [GO:0006970]; stress-activated MAPK cascade [GO:0051403]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell cycle [GO:0007049]; cellular response to anisomycin [GO:0072740]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to sodium arsenite [GO:1903936]; cellular response to sorbitol [GO:0072709]; cellular response to UV [GO:0034644]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; response to osmotic stress [GO:0006970]; stress-activated MAPK cascade [GO:0051403]	
O15265	reviewed	ATX7_HUMAN	Ataxin-7 (Spinocerebellar ataxia type 7 protein)	ATXN7 SCA7	Homo sapiens (Human)	892	FUNCTION: Acts as component of the STAGA transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762}.		microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; nucleus organization [GO:0006997]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601]	cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]		cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; nucleus organization [GO:0006997]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: [Isoform a]: Nucleus {ECO:0000269|PubMed:12533095, ECO:0000269|PubMed:16314424, ECO:0000269|PubMed:22100762}. Nucleus, nucleolus {ECO:0000269|PubMed:10441328}. Nucleus matrix {ECO:0000269|PubMed:10441328}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22100762}. Note=In addition to a diffuse distribution throughout the nucleus, it is associated with the nuclear matrix and the nucleolus (PubMed:10441328). It is able to shuttle between the nucleus and cytoplasm (PubMed:16314424). {ECO:0000269|PubMed:10441328, ECO:0000269|PubMed:16314424}.; SUBCELLULAR LOCATION: [Isoform b]: Cytoplasm {ECO:0000269|PubMed:12533095}.
O15266	reviewed	SHOX_HUMAN	Short stature homeobox protein (Pseudoautosomal homeobox-containing osteogenic protein) (Short stature homeobox-containing protein)	SHOX PHOG	Homo sapiens (Human)	292	FUNCTION: Controls fundamental aspects of growth and development.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
O15269	reviewed	SPTC1_HUMAN	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)	SPTLC1 LCB1	Homo sapiens (Human)	473	FUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core (PubMed:19416851, PubMed:33558762). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851, PubMed:33558762). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19648650, PubMed:19416851). The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19648650, PubMed:19416851, PubMed:33558761, PubMed:33558762). Required for adipocyte cell viability and metabolic homeostasis (By similarity). {ECO:0000250|UniProtKB:O35704, ECO:0000269|PubMed:19416851, ECO:0000269|PubMed:19648650, ECO:0000269|PubMed:33558761, ECO:0000269|PubMed:33558762}.		ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; regulation of fat cell apoptotic process [GO:1904649]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid metabolic process [GO:0006665]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; serine C-palmitoyltransferase complex [GO:0017059]; SPOTS complex [GO:0035339]	pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; serine C-palmitoyltransferase complex [GO:0017059]; SPOTS complex [GO:0035339]; pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758]; ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; regulation of fat cell apoptotic process [GO:1904649]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid metabolic process [GO:0006665]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21618344}; Single-pass membrane protein {ECO:0000250|UniProtKB:O35704}.
O15270	reviewed	SPTC2_HUMAN	Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)	SPTLC2 KIAA0526 LCB2	Homo sapiens (Human)	562	FUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:19648650, PubMed:19416851, PubMed:20920666, PubMed:20504773). The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core (PubMed:19416851). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19648650, PubMed:19416851). The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19648650, PubMed:19416851). Crucial for adipogenesis (By similarity). {ECO:0000250|UniProtKB:P97363, ECO:0000269|PubMed:19416851, ECO:0000269|PubMed:19648650, ECO:0000269|PubMed:20504773, ECO:0000269|PubMed:20920666}.		adipose tissue development [GO:0060612]; ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512]	endoplasmic reticulum membrane [GO:0005789]; serine C-palmitoyltransferase complex [GO:0017059]	pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758]	endoplasmic reticulum membrane [GO:0005789]; serine C-palmitoyltransferase complex [GO:0017059]; pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758]; adipose tissue development [GO:0060612]; ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P97363}; Single-pass membrane protein {ECO:0000250|UniProtKB:P97363}.
O15273	reviewed	TELT_HUMAN	Telethonin (Titin cap protein)	TCAP	Homo sapiens (Human)	167	FUNCTION: Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.	MISCELLANEOUS: The C-terminal domain appears to be unstructured in solution. It may promote the assembly of higher-order TTN complexes.	adult heart development [GO:0007512]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of mechanical stimulus [GO:0050982]; detection of muscle stretch [GO:0035995]; otic vesicle formation [GO:0030916]; protein-containing complex assembly [GO:0065003]; response to muscle stretch [GO:0035994]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle contraction [GO:0003009]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]	cytosol [GO:0005829]; I band [GO:0031674]; Z disc [GO:0030018]	BMP binding [GO:0036122]; FATZ binding [GO:0051373]; molecular adaptor activity [GO:0060090]; protein-macromolecule adaptor activity [GO:0030674]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]; titin Z domain binding [GO:0070080]; transmembrane transporter binding [GO:0044325]	cytosol [GO:0005829]; I band [GO:0031674]; Z disc [GO:0030018]; BMP binding [GO:0036122]; FATZ binding [GO:0051373]; molecular adaptor activity [GO:0060090]; protein-macromolecule adaptor activity [GO:0030674]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]; titin Z domain binding [GO:0070080]; transmembrane transporter binding [GO:0044325]; adult heart development [GO:0007512]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of mechanical stimulus [GO:0050982]; detection of muscle stretch [GO:0035995]; otic vesicle formation [GO:0030916]; protein-containing complex assembly [GO:0065003]; response to muscle stretch [GO:0035994]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle contraction [GO:0003009]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:16713295}.
O15287	reviewed	FANCG_HUMAN	Fanconi anemia group G protein (Protein FACG) (DNA repair protein XRCC9)	FANCG XRCC9	Homo sapiens (Human)	622	FUNCTION: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; interstrand cross-link repair [GO:0036297]; mitochondrion organization [GO:0007005]; ovarian follicle development [GO:0001541]; response to radiation [GO:0009314]; spermatid development [GO:0007286]	chromatin [GO:0000785]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	damaged DNA binding [GO:0003684]	chromatin [GO:0000785]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; damaged DNA binding [GO:0003684]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; interstrand cross-link repair [GO:0036297]; mitochondrion organization [GO:0007005]; ovarian follicle development [GO:0001541]; response to radiation [GO:0009314]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18550849}. Cytoplasm {ECO:0000269|PubMed:18550849}. Note=The major form is nuclear. The minor form is cytoplasmic.
O15294	reviewed	OGT1_HUMAN	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT)	OGT	Homo sapiens (Human)	1046	FUNCTION: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:26678539, PubMed:26369908, PubMed:23103939, PubMed:21240259, PubMed:21285374, PubMed:15361863). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, ATG4B, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU, NOD2 and HCFC1 (PubMed:19451179, PubMed:20200153, PubMed:21285374, PubMed:22923583, PubMed:23353889, PubMed:24474760, PubMed:26678539, PubMed:26369908, PubMed:27527864, PubMed:34074792). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (PubMed:26678539). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2 (PubMed:12150998, PubMed:19451179, PubMed:20018868, PubMed:20200153, PubMed:21285374, PubMed:15361863). O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (PubMed:21285374, PubMed:28584052, PubMed:28302723). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Glycosylates HOXA1 (By similarity). O-glycosylates FNIP1 (PubMed:30699359). Promotes autophagy by mediating O-glycosylation of ATG4B (PubMed:27527864). {ECO:0000250|UniProtKB:P56558, ECO:0000250|UniProtKB:Q8CGY8, ECO:0000269|PubMed:12150998, ECO:0000269|PubMed:15361863, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20018868, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:21240259, ECO:0000269|PubMed:21285374, ECO:0000269|PubMed:22121020, ECO:0000269|PubMed:22923583, ECO:0000269|PubMed:23103939, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:26369908, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28302723, ECO:0000269|PubMed:28584052, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:34074792}.; FUNCTION: [Isoform 2]: The mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line. {ECO:0000269|PubMed:20824293}.		apoptotic process [GO:0006915]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; hemopoiesis [GO:0030097]; mitophagy [GO:0000423]; negative regulation of cell migration [GO:0030336]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of proteolysis [GO:0045862]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; positive regulation of translation [GO:0045727]; protein O-linked glycosylation [GO:0006493]; protein processing [GO:0016485]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; regulation of gluconeogenesis [GO:0006111]; regulation of glycolytic process [GO:0006110]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of necroptotic process [GO:0060544]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Rac protein signal transduction [GO:0035020]; regulation of synapse assembly [GO:0051963]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; response to nutrient [GO:0007584]; signal transduction [GO:0007165]	cell projection [GO:0042995]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; histone acetyltransferase complex [GO:0000123]; mitochondrial membrane [GO:0031966]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein N-acetylglucosaminyltransferase complex [GO:0017122]; protein-containing complex [GO:0032991]; Sin3 complex [GO:0016580]	acetylglucosaminyltransferase activity [GO:0008375]; chromatin DNA binding [GO:0031490]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein O-acetylglucosaminyltransferase activity [GO:0097363]	cell projection [GO:0042995]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; histone acetyltransferase complex [GO:0000123]; mitochondrial membrane [GO:0031966]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein N-acetylglucosaminyltransferase complex [GO:0017122]; protein-containing complex [GO:0032991]; Sin3 complex [GO:0016580]; acetylglucosaminyltransferase activity [GO:0008375]; chromatin DNA binding [GO:0031490]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein O-acetylglucosaminyltransferase activity [GO:0097363]; apoptotic process [GO:0006915]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; hemopoiesis [GO:0030097]; mitophagy [GO:0000423]; negative regulation of cell migration [GO:0030336]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of proteolysis [GO:0045862]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; positive regulation of translation [GO:0045727]; protein O-linked glycosylation [GO:0006493]; protein processing [GO:0016485]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; regulation of gluconeogenesis [GO:0006111]; regulation of glycolytic process [GO:0006110]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of necroptotic process [GO:0060544]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Rac protein signal transduction [GO:0035020]; regulation of synapse assembly [GO:0051963]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; response to nutrient [GO:0007584]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26678539}. Cytoplasm {ECO:0000269|PubMed:26678539}. Note=Predominantly localizes to the nucleus. {ECO:0000269|PubMed:26678539}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000269|PubMed:20824293}. Membrane {ECO:0000269|PubMed:20824293}. Note=Associates with the mitochondrial inner membrane. {ECO:0000269|PubMed:20824293}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:21285374}. Nucleus {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21285374}. Cell membrane {ECO:0000250|UniProtKB:P56558}. Mitochondrion membrane {ECO:0000250|UniProtKB:P56558}. Cell projection {ECO:0000250|UniProtKB:P56558}. Note=Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1 (PubMed:21285374). After insulin induction, translocated from the nucleus to the cell membrane via phosphatidylinositide binding. Colocalizes with AKT1 at the plasma membrane. TRAK1 recruits this protein to mitochondria. In the absence of TRAK1, localizes in cytosol and nucleus (By similarity). {ECO:0000250|UniProtKB:P56558, ECO:0000269|PubMed:21285374}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus.
O15296	reviewed	LX15B_HUMAN	Polyunsaturated fatty acid lipoxygenase ALOX15B (15-lipoxygenase 2) (15-LOX-2) (Arachidonate 15-lipoxygenase B) (15-LOX-B) (EC 1.13.11.33) (Arachidonate 15-lipoxygenase type II) (Linoleate 13-lipoxygenase 15-LOb) (EC 1.13.11.-)	ALOX15B	Homo sapiens (Human)	676	FUNCTION: [Isoform A]: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (PubMed:9177185, PubMed:10625675, PubMed:12704195, PubMed:17493578, PubMed:18311922, PubMed:24282679, PubMed:10542053, PubMed:24497644, PubMed:32404334) (Probable). It inserts peroxyl groups at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (PubMed:17493578, PubMed:12704195, PubMed:24282679, PubMed:9177185, PubMed:11956198, PubMed:10625675, PubMed:24497644) (Probable). Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (Probable) (PubMed:10542053, PubMed:27435673). Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist (PubMed:18311922, PubMed:17493578, PubMed:11956198). Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates (PubMed:27145229). Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively down-regulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids (PubMed:27435673). Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation (PubMed:12704195, PubMed:11839751). May also regulate cytokine secretion by macrophages and therefore play a role in the immune response (PubMed:18067895). May also regulate macrophage differentiation into proatherogenic foam cells (PubMed:22912809). {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:10625675, ECO:0000269|PubMed:11839751, ECO:0000269|PubMed:11956198, ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:17493578, ECO:0000269|PubMed:18067895, ECO:0000269|PubMed:18311922, ECO:0000269|PubMed:22912809, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:24497644, ECO:0000269|PubMed:27145229, ECO:0000269|PubMed:27435673, ECO:0000269|PubMed:32404334, ECO:0000269|PubMed:9177185, ECO:0000305|PubMed:10542053, ECO:0000305|PubMed:16112079, ECO:0000305|PubMed:27145229, ECO:0000305|PubMed:27435673}.; FUNCTION: [Isoform B]: Does not convert arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. {ECO:0000269|PubMed:12704195}.		apoptotic process [GO:0006915]; arachidonic acid metabolic process [GO:0019369]; cannabinoid biosynthetic process [GO:1901696]; endocannabinoid signaling pathway [GO:0071926]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxygenase pathway [GO:0019372]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of growth [GO:0045926]; phospholipid metabolic process [GO:0006644]; positive regulation of chemokine production [GO:0032722]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; prostate gland development [GO:0030850]; regulation of epithelial cell differentiation [GO:0030856]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	arachidonate 15-lipoxygenase activity [GO:0050473]; arachidonate 8(S)-lipoxygenase activity [GO:0036403]; calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165]; linoleate 9S-lipoxygenase activity [GO:1990136]; lipid binding [GO:0008289]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; arachidonate 15-lipoxygenase activity [GO:0050473]; arachidonate 8(S)-lipoxygenase activity [GO:0036403]; calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165]; linoleate 9S-lipoxygenase activity [GO:1990136]; lipid binding [GO:0008289]; apoptotic process [GO:0006915]; arachidonic acid metabolic process [GO:0019369]; cannabinoid biosynthetic process [GO:1901696]; endocannabinoid signaling pathway [GO:0071926]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxygenase pathway [GO:0019372]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of growth [GO:0045926]; phospholipid metabolic process [GO:0006644]; positive regulation of chemokine production [GO:0032722]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; prostate gland development [GO:0030850]; regulation of epithelial cell differentiation [GO:0030856]	SUBCELLULAR LOCATION: [Isoform A]: Nucleus {ECO:0000269|PubMed:12704195}. Note=Other isoforms are excluded from the nucleus. {ECO:0000269|PubMed:12704195}.; SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12704195}. Cell membrane {ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:27435673}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12704195}. Membrane {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:24497644}; Peripheral membrane protein {ECO:0000269|PubMed:24497644}. Cell junction, adherens junction {ECO:0000269|PubMed:12704195}. Cell junction, focal adhesion {ECO:0000269|PubMed:12704195}. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:24497644, ECO:0000269|PubMed:27435673}.
O15297	reviewed	PPM1D_HUMAN	Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)	PPM1D WIP1	Homo sapiens (Human)	605	FUNCTION: Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). {ECO:0000250|UniProtKB:Q9QZ67, ECO:0000269|PubMed:15870257, ECO:0000269|PubMed:16311512, ECO:0000269|PubMed:21283629, ECO:0000269|PubMed:23242139}.		cellular response to starvation [GO:0009267]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA methylation [GO:0006306]; G2/M transition of mitotic cell cycle [GO:0000086]; heterochromatin formation [GO:0031507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression, epigenetic [GO:0045814]; peptidyl-threonine dephosphorylation [GO:0035970]; protein dephosphorylation [GO:0006470]; regulation of transcription initiation by RNA polymerase II [GO:0060260]; response to bacterium [GO:0009617]; response to radiation [GO:0009314]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; myosin phosphatase activity [GO:0017018]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; myosin phosphatase activity [GO:0017018]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine phosphatase activity [GO:0004722]; cellular response to starvation [GO:0009267]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA methylation [GO:0006306]; G2/M transition of mitotic cell cycle [GO:0000086]; heterochromatin formation [GO:0031507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression, epigenetic [GO:0045814]; peptidyl-threonine dephosphorylation [GO:0035970]; protein dephosphorylation [GO:0006470]; regulation of transcription initiation by RNA polymerase II [GO:0060260]; response to bacterium [GO:0009617]; response to radiation [GO:0009314]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28343630, ECO:0000269|PubMed:9177166}. Cytoplasm, cytosol {ECO:0000269|PubMed:28343630}.
O15303	reviewed	GRM6_HUMAN	Metabotropic glutamate receptor 6 (mGluR6)	GRM6 GPRC1F MGLUR6	Homo sapiens (Human)	877	FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. {ECO:0000250, ECO:0000269|PubMed:23452348}.		chemical synaptic transmission [GO:0007268]; detection of light stimulus involved in visual perception [GO:0050908]; detection of visible light [GO:0009584]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; locomotory behavior [GO:0007626]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; regulation of synaptic transmission, glutamatergic [GO:0051966]; retina development in camera-type eye [GO:0060041]	dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; new growing cell tip [GO:0035841]; plasma membrane [GO:0005886]; synapse [GO:0045202]	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; protein homodimerization activity [GO:0042803]	dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; new growing cell tip [GO:0035841]; plasma membrane [GO:0005886]; synapse [GO:0045202]; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; protein homodimerization activity [GO:0042803]; chemical synaptic transmission [GO:0007268]; detection of light stimulus involved in visual perception [GO:0050908]; detection of visible light [GO:0009584]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; locomotory behavior [GO:0007626]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; regulation of synaptic transmission, glutamatergic [GO:0051966]; retina development in camera-type eye [GO:0060041]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Golgi apparatus membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Cell projection, dendrite {ECO:0000250}. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
O15304	reviewed	SIVA_HUMAN	Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP)	SIVA1 SIVA	Homo sapiens (Human)	175	FUNCTION: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. {ECO:0000269|PubMed:12011449, ECO:0000269|PubMed:14739602, ECO:0000269|PubMed:15034012, ECO:0000269|PubMed:15958577, ECO:0000269|PubMed:16491128}.	MISCELLANEOUS: [Isoform 2]: Mouse isoform 2 has been shown (PubMed:9177220) to have no pro-apoptotic activity. However, human isoform 2 has been shown to be capable of inducing apoptosis (PubMed:15034012). {ECO:0000305|PubMed:15034012, ECO:0000305|PubMed:9177220}.	activation-induced cell death of T cells [GO:0006924]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	CD27 receptor binding [GO:0005175]; metal ion binding [GO:0046872]; tumor necrosis factor receptor binding [GO:0005164]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; CD27 receptor binding [GO:0005175]; metal ion binding [GO:0046872]; tumor necrosis factor receptor binding [GO:0005164]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]; activation-induced cell death of T cells [GO:0006924]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15034012}. Nucleus {ECO:0000269|PubMed:15034012}. Note=In the nucleus, accumulates in dot-like structures.
O15305	reviewed	PMM2_HUMAN	Phosphomannomutase 2 (PMM 2) (EC 5.4.2.8)	PMM2	Homo sapiens (Human)	246	FUNCTION: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. {ECO:0000250|UniProtKB:Q92871}.		GDP-mannose biosynthetic process [GO:0009298]; mannose metabolic process [GO:0006013]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]	cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; phosphomannomutase activity [GO:0004615]	cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; phosphomannomutase activity [GO:0004615]; GDP-mannose biosynthetic process [GO:0009298]; mannose metabolic process [GO:0006013]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]	SUBCELLULAR LOCATION: Cytoplasm.
O15315	reviewed	RA51B_HUMAN	DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1)	RAD51B RAD51L1 REC2	Homo sapiens (Human)	384	FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11751636, ECO:0000269|PubMed:11842113, ECO:0000269|PubMed:12441335, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.		blastocyst growth [GO:0001832]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; somite development [GO:0061053]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]; blastocyst growth [GO:0001832]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; somite development [GO:0061053]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O15318	reviewed	RPC7_HUMAN	DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) (DNA-directed RNA polymerase III subunit G) (RNA polymerase III 32 kDa apha subunit) (RPC32-alpha) (RNA polymerase III 32 kDa subunit) (RPC32)	POLR3G	Homo sapiens (Human)	223	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:20154270). May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20154270}.		cell population proliferation [GO:0008283]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase III [GO:0006383]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]	chromatin binding [GO:0003682]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]; chromatin binding [GO:0003682]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; cell population proliferation [GO:0008283]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20154270, ECO:0000269|PubMed:21898682}. Cytoplasm {ECO:0000250|UniProtKB:Q6NXY9}. Note=Excluded from nucleoli (PubMed:21898682). In zygotes and the 2-cell stage embryos, mainly in the cytoplasm. Starts to localize to the nucleus in the 8-16 cell stage embryo and early blastocysts (By similarity). {ECO:0000250|UniProtKB:Q6NXY9, ECO:0000269|PubMed:21898682}.
O15327	reviewed	INP4B_HUMAN	Inositol polyphosphate 4-phosphatase type II (Type II inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66)	INPP4B	Homo sapiens (Human)	924	FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). {ECO:0000269|PubMed:19647222, ECO:0000269|PubMed:24070612, ECO:0000269|PubMed:24591580}.		inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	inositol-1,3,4-trisphosphate 4-phosphatase activity [GO:0017161]; inositol-3,4-bisphosphate 4-phosphatase activity [GO:0052828]; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity [GO:0016316]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; inositol-1,3,4-trisphosphate 4-phosphatase activity [GO:0017161]; inositol-3,4-bisphosphate 4-phosphatase activity [GO:0052828]; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity [GO:0016316]; inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; signal transduction [GO:0007165]	
O15342	reviewed	VA0E1_HUMAN	V-type proton ATPase subunit e 1 (V-ATPase subunit e 1) (V-ATPase 9.2 kDa membrane accessory protein) (V-ATPase M9.2 subunit) (Vacuolar proton pump subunit e 1)	ATP6V0E1 ATP6H ATP6V0E	Homo sapiens (Human)	81	FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). {ECO:0000250|UniProtKB:Q2KIB5, ECO:0000269|PubMed:33065002}.		proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; transmembrane transport [GO:0055085]; vacuolar acidification [GO:0007035]	endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; proton-transporting V-type ATPase, V0 domain [GO:0033179]	ATPase-coupled ion transmembrane transporter activity [GO:0042625]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; proton-transporting V-type ATPase, V0 domain [GO:0033179]; ATPase-coupled ion transmembrane transporter activity [GO:0042625]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; transmembrane transport [GO:0055085]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
O15344	reviewed	TRI18_HUMAN	E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)	MID1 FXY RNF59 TRIM18 XPRF	Homo sapiens (Human)	667	FUNCTION: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}.		microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; pattern specification process [GO:0007389]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein localization to microtubule [GO:0035372]; regulation of microtubule cytoskeleton organization [GO:0070507]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; spindle [GO:0005819]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; transferase activity [GO:0016740]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; spindle [GO:0005819]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; transferase activity [GO:0016740]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; pattern specification process [GO:0007389]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein localization to microtubule [GO:0035372]; regulation of microtubule cytoskeleton organization [GO:0070507]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10077590}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10077590}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10077590}. Note=Microtubule-associated. It is associated with microtubules throughout the cell cycle, co-localizing with cytoplasmic fibers in interphase and with the mitotic spindle and midbodies during mitosis and cytokinesis.
O15347	reviewed	HMGB3_HUMAN	High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4)	HMGB3 HMG2A HMG4	Homo sapiens (Human)	200	FUNCTION: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). {ECO:0000250|UniProtKB:O54879, ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P40618}.		DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; innate immune response [GO:0045087]; regulation of transcription by RNA polymerase II [GO:0006357]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA binding, bending [GO:0008301]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; RNA binding [GO:0003723]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding, bending [GO:0008301]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; RNA binding [GO:0003723]; DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; innate immune response [GO:0045087]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40618, ECO:0000255|PROSITE-ProRule:PRU00267}. Chromosome {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:O54879}.
O15350	reviewed	P73_HUMAN	Tumor protein p73 (p53-like transcription factor) (p53-related protein)	TP73 P73	Homo sapiens (Human)	636	FUNCTION: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}.	MISCELLANEOUS: Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not to be frequently mutated in human cancers, in contrast to p53/TP53. Hemizygosity is observed in neuroblastoma and oligodendroglioma.; MISCELLANEOUS: Activated and stabilized by interaction with RANBP9.; MISCELLANEOUS: [Isoform Beta]: Produced by alternative splicing of isoform Alpha. {ECO:0000305}.; MISCELLANEOUS: [Isoform Gamma]: Produced by alternative splicing of isoform Alpha. The splicing of exon 11 results in a frameshift from the original reading frame. {ECO:0000305}.; MISCELLANEOUS: [Isoform Delta]: Produced by alternative splicing of isoform Alpha. {ECO:0000305}.; MISCELLANEOUS: [Isoform Epsilon]: Produced by alternative splicing of isoform Alpha. The splicing of exon 11 results in a frameshift from the original reading frame. The splicing of exon 13 reverts the reading frame to the sequence of isoform Alpha. {ECO:0000305}.; MISCELLANEOUS: [Isoform Zeta]: Produced by alternative splicing of isoform Alpha. {ECO:0000305}.; MISCELLANEOUS: [Isoform dN-Alpha]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform dN-Beta]: Produced by alternative splicing of isoform dN-Alpha. {ECO:0000305}.; MISCELLANEOUS: [Isoform dN-Gamma]: Produced by alternative splicing of isoform dN-Alpha. {ECO:0000305}.	cell cycle [GO:0007049]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; kidney development [GO:0001822]; mismatch repair [GO:0006298]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lung ciliated cell differentiation [GO:1901248]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein tetramerization [GO:0051262]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]; response to organonitrogen compound [GO:0010243]; response to xenobiotic stimulus [GO:0009410]	cell junction [GO:0030054]; chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]	cell junction [GO:0030054]; chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; cell cycle [GO:0007049]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; kidney development [GO:0001822]; mismatch repair [GO:0006298]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lung ciliated cell differentiation [GO:1901248]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein tetramerization [GO:0051262]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]; response to organonitrogen compound [GO:0010243]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24314664}. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage.
O15353	reviewed	FOXN1_HUMAN	Forkhead box protein N1 (Winged-helix transcription factor nude)	FOXN1 RONU WHN	Homo sapiens (Human)	648	FUNCTION: Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891). {ECO:0000250|UniProtKB:Q61575, ECO:0000269|PubMed:21507891}.		animal organ morphogenesis [GO:0009887]; blood vessel morphogenesis [GO:0048514]; defense response [GO:0006952]; epidermis development [GO:0008544]; hair follicle development [GO:0001942]; keratinocyte differentiation [GO:0030216]; lymphoid lineage cell migration into thymus [GO:0097535]; nail development [GO:0035878]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of hair follicle development [GO:0051798]; regulation of positive thymic T cell selection [GO:1902232]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell homeostasis [GO:0043029]; T cell lineage commitment [GO:0002360]; thymus epithelium morphogenesis [GO:0097536]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; transcription cis-regulatory region binding [GO:0000976]; animal organ morphogenesis [GO:0009887]; blood vessel morphogenesis [GO:0048514]; defense response [GO:0006952]; epidermis development [GO:0008544]; hair follicle development [GO:0001942]; keratinocyte differentiation [GO:0030216]; lymphoid lineage cell migration into thymus [GO:0097535]; nail development [GO:0035878]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of hair follicle development [GO:0051798]; regulation of positive thymic T cell selection [GO:1902232]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell homeostasis [GO:0043029]; T cell lineage commitment [GO:0002360]; thymus epithelium morphogenesis [GO:0097536]	SUBCELLULAR LOCATION: Nucleus.
O15354	reviewed	GPR37_HUMAN	Prosaposin receptor GPR37 (Endothelin B receptor-like protein 1) (ETBR-LP-1) (G-protein coupled receptor 37) (Parkin-associated endothelin receptor-like receptor) (PAELR)	GPR37	Homo sapiens (Human)	613	FUNCTION: Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. {ECO:0000269|PubMed:11439185, ECO:0000269|PubMed:23690594, ECO:0000269|PubMed:9526070}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to reactive oxygen species [GO:0034614]; dendrite development [GO:0016358]; dopamine biosynthetic process [GO:0042416]; G protein-coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuropeptide signaling pathway [GO:0007218]; positive regulation of dopamine metabolic process [GO:0045964]; positive regulation of MAPK cascade [GO:0043410]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; synapse [GO:0045202]; ubiquitin ligase complex [GO:0000151]	G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; PDZ domain binding [GO:0030165]; peptide binding [GO:0042277]; prosaposin receptor activity [GO:0036505]; ubiquitin protein ligase binding [GO:0031625]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; synapse [GO:0045202]; ubiquitin ligase complex [GO:0000151]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; PDZ domain binding [GO:0030165]; peptide binding [GO:0042277]; prosaposin receptor activity [GO:0036505]; ubiquitin protein ligase binding [GO:0031625]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to reactive oxygen species [GO:0034614]; dendrite development [GO:0016358]; dopamine biosynthetic process [GO:0042416]; G protein-coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuropeptide signaling pathway [GO:0007218]; positive regulation of dopamine metabolic process [GO:0045964]; positive regulation of MAPK cascade [GO:0043410]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}.
O15355	reviewed	PPM1G_HUMAN	Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma)	PPM1G PPM1C	Homo sapiens (Human)	546			peptidyl-threonine dephosphorylation [GO:0035970]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; peptidyl-threonine dephosphorylation [GO:0035970]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
O15357	reviewed	SHIP2_HUMAN	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)	INPPL1 SHIP2	Homo sapiens (Human)	1258	FUNCTION: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}.	MISCELLANEOUS: Its ability to confer resistance to dietary obesity suggests that it may serve as a possible therapeutic target in cases of type 2 diabetes and obesity.	actin filament organization [GO:0007015]; cell adhesion [GO:0007155]; endochondral ossification [GO:0001958]; endocytosis [GO:0006897]; establishment of mitotic spindle orientation [GO:0000132]; glucose metabolic process [GO:0006006]; immune system process [GO:0002376]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; post-embryonic development [GO:0009791]; regulation of actin filament organization [GO:0110053]; regulation of immune response [GO:0050776]; regulation of protein localization [GO:0032880]; response to insulin [GO:0032868]; ruffle assembly [GO:0097178]	basal plasma membrane [GO:0009925]; cytosol [GO:0005829]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spindle pole [GO:0000922]	actin binding [GO:0003779]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]	basal plasma membrane [GO:0009925]; cytosol [GO:0005829]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spindle pole [GO:0000922]; actin binding [GO:0003779]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; actin filament organization [GO:0007015]; cell adhesion [GO:0007155]; endochondral ossification [GO:0001958]; endocytosis [GO:0006897]; establishment of mitotic spindle orientation [GO:0000132]; glucose metabolic process [GO:0006006]; immune system process [GO:0002376]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; post-embryonic development [GO:0009791]; regulation of actin filament organization [GO:0110053]; regulation of immune response [GO:0050776]; regulation of protein localization [GO:0032880]; response to insulin [GO:0032868]; ruffle assembly [GO:0097178]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11349134}. Cytoplasm, cytoskeleton. Membrane {ECO:0000269|PubMed:11739414}; Peripheral membrane protein. Cell projection, filopodium {ECO:0000269|PubMed:12676785}. Cell projection, lamellipodium {ECO:0000269|PubMed:12676785}. Basal cell membrane {ECO:0000250|UniProtKB:F1PNY0}. Nucleus {ECO:0000250|UniProtKB:D7PF45}. Nucleus speckle {ECO:0000250|UniProtKB:D7PF45}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:F1PNY0}. Note=Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type (PubMed:11739414). Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates its redistribution from the cytosol to the plasma membrane. Recruited to the membrane following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia and the central actin ring. {ECO:0000269|PubMed:11739414}.
O15360	reviewed	FANCA_HUMAN	Fanconi anemia group A protein (Protein FACA)	FANCA FAA FACA FANCH	Homo sapiens (Human)	1455	FUNCTION: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.		DNA repair [GO:0006281]; female gonad development [GO:0008585]; interstrand cross-link repair [GO:0036297]; male gonad development [GO:0008584]; male meiotic nuclear division [GO:0007140]; protein-containing complex assembly [GO:0065003]; regulation of CD40 signaling pathway [GO:2000348]; regulation of germ cell proliferation [GO:1905936]; regulation of inflammatory response [GO:0050727]; regulation of regulatory T cell differentiation [GO:0045589]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		chromatin [GO:0000785]; cytoplasm [GO:0005737]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA repair [GO:0006281]; female gonad development [GO:0008585]; interstrand cross-link repair [GO:0036297]; male gonad development [GO:0008584]; male meiotic nuclear division [GO:0007140]; protein-containing complex assembly [GO:0065003]; regulation of CD40 signaling pathway [GO:2000348]; regulation of germ cell proliferation [GO:1905936]; regulation of inflammatory response [GO:0050727]; regulation of regulatory T cell differentiation [GO:0045589]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.
O15371	reviewed	EIF3D_HUMAN	Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66)	EIF3D EIF3S7	Homo sapiens (Human)	548	FUNCTION: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.		cap-dependent translational initiation [GO:0002191]; formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; synapse [GO:0045202]	mRNA cap binding [GO:0098808]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; synapse [GO:0045202]; mRNA cap binding [GO:0098808]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; cap-dependent translational initiation [GO:0002191]; formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}.
O15372	reviewed	EIF3H_HUMAN	Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit)	EIF3H EIF3S3	Homo sapiens (Human)	352	FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.		formation of cytoplasmic translation initiation complex [GO:0001732]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]	metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; formation of cytoplasmic translation initiation complex [GO:0001732]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
O15374	reviewed	MOT5_HUMAN	Monocarboxylate transporter 5 (MCT 5) (Monocarboxylate transporter 4) (MCT 4) (Solute carrier family 16 member 4)	SLC16A4 MCT4 MCT5	Homo sapiens (Human)	487	FUNCTION: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}.		monocarboxylic acid transport [GO:0015718]	membrane [GO:0016020]; plasma membrane [GO:0005886]	monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]	membrane [GO:0016020]; plasma membrane [GO:0005886]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]; monocarboxylic acid transport [GO:0015718]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O15379	reviewed	HDAC3_HUMAN	Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)	HDAC3	Homo sapiens (Human)	428	FUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates (PubMed:23911289, PubMed:21030595, PubMed:21444723, PubMed:25301942, PubMed:28497810, PubMed:28167758, PubMed:32404892). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:23911289). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:23911289). Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression (PubMed:23911289). Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (By similarity). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (By similarity). During the activation phase, promotes the accumulation of ubiquitinated BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and BMAL1 (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Also functions as deacetylase for non-histone targets, such as KAT5, MEF2D, MAPK14 and RARA (PubMed:21030595, PubMed:21444723, PubMed:25301942, PubMed:28167758). Serves as a corepressor of RARA, mediating its deacetylation and repression, leading to inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:34608293). Catalyzes decrotonylation of MAPRE1/EB1 (PubMed:34608293). {ECO:0000250|UniProtKB:O88895, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21444723, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25301942, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:32404892, ECO:0000269|PubMed:34608293}.		cellular response to fluid shear stress [GO:0071498]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; cornified envelope assembly [GO:1903575]; DNA repair-dependent chromatin remodeling [GO:0140861]; establishment of mitotic spindle orientation [GO:0000132]; establishment of skin barrier [GO:0061436]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JNK cascade [GO:0046329]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; regulation of circadian rhythm [GO:0042752]; regulation of mitotic cell cycle [GO:0007346]; regulation of multicellular organism growth [GO:0040014]; regulation of protein stability [GO:0031647]; spindle assembly [GO:0051225]; transcription by RNA polymerase II [GO:0006366]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone deacetylase complex [GO:0000118]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; cyclin binding [GO:0030332]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; NF-kappaB binding [GO:0051059]; protein de-2-hydroxyisobutyrylase activity [GO:0160010]; protein decrotonylase activity [GO:0160008]; protein lysine deacetylase activity [GO:0033558]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone deacetylase complex [GO:0000118]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; cyclin binding [GO:0030332]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; NF-kappaB binding [GO:0051059]; protein de-2-hydroxyisobutyrylase activity [GO:0160010]; protein decrotonylase activity [GO:0160008]; protein lysine deacetylase activity [GO:0033558]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; cellular response to fluid shear stress [GO:0071498]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; cornified envelope assembly [GO:1903575]; DNA repair-dependent chromatin remodeling [GO:0140861]; establishment of mitotic spindle orientation [GO:0000132]; establishment of skin barrier [GO:0061436]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JNK cascade [GO:0046329]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; regulation of circadian rhythm [GO:0042752]; regulation of mitotic cell cycle [GO:0007346]; regulation of multicellular organism growth [GO:0040014]; regulation of protein stability [GO:0031647]; spindle assembly [GO:0051225]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21030595}. Cytoplasm {ECO:0000269|PubMed:25190803}. Cytoplasm, cytosol {ECO:0000269|PubMed:21030595}. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2 (PubMed:21030595). {ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:25190803}.
O15381	reviewed	NVL_HUMAN	Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein)	NVL NVL2	Homo sapiens (Human)	856	FUNCTION: Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}.		positive regulation of protein binding [GO:0032092]; positive regulation of telomerase activity [GO:0051973]; regulation of protein localization to nucleolus [GO:1904749]; ribosomal large subunit biogenesis [GO:0042273]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275]; RNA binding [GO:0003723]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275]; RNA binding [GO:0003723]; positive regulation of protein binding [GO:0032092]; positive regulation of telomerase activity [GO:0051973]; regulation of protein localization to nucleolus [GO:1904749]; ribosomal large subunit biogenesis [GO:0042273]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, nucleoplasm {ECO:0000269|PubMed:15469983}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:9286697}. Nucleus, nucleoplasm {ECO:0000269|PubMed:15469983}. Note=Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus. {ECO:0000269|PubMed:16782053}.
O15382	reviewed	BCAT2_HUMAN	Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT(m)) (EC 2.6.1.42) (Placental protein 18) (PP18)	BCAT2 BCATM BCT2 ECA40	Homo sapiens (Human)	392	FUNCTION: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine (PubMed:8702755, PubMed:25653144, PubMed:17050531). May also function as a transporter of branched chain alpha-keto acids (By similarity). {ECO:0000250|UniProtKB:O35854, ECO:0000269|PubMed:17050531, ECO:0000269|PubMed:25653144, ECO:0000269|PubMed:8702755}.		branched-chain amino acid biosynthetic process [GO:0009082]; cellular response to leukemia inhibitory factor [GO:1990830]; isoleucine catabolic process [GO:0006550]; leucine biosynthetic process [GO:0009098]; lipid metabolic process [GO:0006629]; regulation of hormone levels [GO:0010817]; valine biosynthetic process [GO:0009099]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	branched-chain-amino-acid transaminase activity [GO:0004084]; L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-leucine:2-oxoglutarate aminotransferase activity [GO:0050048]; L-valine transaminase activity [GO:0052655]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; branched-chain-amino-acid transaminase activity [GO:0004084]; L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-leucine:2-oxoglutarate aminotransferase activity [GO:0050048]; L-valine transaminase activity [GO:0052655]; branched-chain amino acid biosynthetic process [GO:0009082]; cellular response to leukemia inhibitory factor [GO:1990830]; isoleucine catabolic process [GO:0006550]; leucine biosynthetic process [GO:0009098]; lipid metabolic process [GO:0006629]; regulation of hormone levels [GO:0010817]; valine biosynthetic process [GO:0009099]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O35854}.
O15389	reviewed	SIGL5_HUMAN	Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170)	SIGLEC5 CD33L2 OBBP2	Homo sapiens (Human)	551	FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.		cell adhesion [GO:0007155]	ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]	carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]	ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]; carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
O15391	reviewed	TYY2_HUMAN	Transcription factor YY2 (Yin and yang 2) (YY-2) (Zinc finger protein 631)	YY2 ZNF631	Homo sapiens (Human)	372	FUNCTION: Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation. {ECO:0000269|PubMed:16260628}.	MISCELLANEOUS: The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene MBTPS2.	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O15392	reviewed	BIRC5_HUMAN	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)	BIRC5 API4 IAP4	Homo sapiens (Human)	142	FUNCTION: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126, PubMed:25778398, PubMed:28218735). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797). {ECO:0000269|PubMed:10626797, ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:16291752, ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:20929775, ECO:0000269|PubMed:21364656, ECO:0000269|PubMed:21536684, ECO:0000269|PubMed:25778398, ECO:0000269|PubMed:28218735, ECO:0000269|PubMed:9859993}.		apoptotic process [GO:0006915]; cell division [GO:0051301]; establishment of chromosome localization [GO:0051303]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of protein phosphorylation [GO:0001934]; protein phosphorylation [GO:0006468]; protein-containing complex localization [GO:0031503]; sensory perception of sound [GO:0007605]	centriole [GO:0005814]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; interphase microtubule organizing center [GO:0031021]; kinetochore [GO:0000776]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; survivin complex [GO:1990713]	cobalt ion binding [GO:0050897]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]	centriole [GO:0005814]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; interphase microtubule organizing center [GO:0031021]; kinetochore [GO:0000776]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; survivin complex [GO:1990713]; cobalt ion binding [GO:0050897]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; cell division [GO:0051301]; establishment of chromosome localization [GO:0051303]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of protein phosphorylation [GO:0001934]; protein phosphorylation [GO:0006468]; protein-containing complex localization [GO:0031503]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:21364656}. Nucleus {ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:21364656}. Chromosome {ECO:0000269|PubMed:14610074}. Chromosome, centromere {ECO:0000269|PubMed:11084331, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:16322459}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11084331}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11084331}. Midbody {ECO:0000269|PubMed:15665297}. Note=Localizes at the centromeres from prophase to metaphase, at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor (By similarity). Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody (PubMed:11084331). Colocalizes with AURKB at mitotic chromosomes (PubMed:14610074). Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export (PubMed:20826784). {ECO:0000250|UniProtKB:E3SCZ8, ECO:0000269|PubMed:11084331, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:20826784}.
O15393	reviewed	TMPS2_HUMAN	Transmembrane protease serine 2 (EC 3.4.21.122) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain]	TMPRSS2 PRSS10	Homo sapiens (Human)	492	FUNCTION: Plasma membrane-anchored serine protease that cleaves at arginine residues (PubMed:32703818). Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). {ECO:0000250|UniProtKB:Q9JIQ8, ECO:0000269|PubMed:15537383, ECO:0000269|PubMed:25122198, ECO:0000269|PubMed:26018085, ECO:0000269|PubMed:32703818}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876). The cleavage of SARS-COV2 spike glycoprotein occurs between the S2 and S2' site (PubMed:32703818). Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32404436, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:34159616}.		positive regulation of viral entry into host cell [GO:0046598]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; viral translation [GO:0019081]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; positive regulation of viral entry into host cell [GO:0046598]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; viral translation [GO:0019081]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}; Single-pass type II membrane protein {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}.; SUBCELLULAR LOCATION: [Transmembrane protease serine 2 catalytic chain]: Secreted {ECO:0000269|PubMed:20382709}. Note=Activated by cleavage and secreted. {ECO:0000269|PubMed:11245484, ECO:0000269|PubMed:20382709}.
O15394	reviewed	NCAM2_HUMAN	Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2)	NCAM2 NCAM21	Homo sapiens (Human)	837	FUNCTION: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.		axonal fasciculation [GO:0007413]; neuron cell-cell adhesion [GO:0007158]	axon [GO:0030424]; membrane [GO:0016020]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	axon [GO:0030424]; membrane [GO:0016020]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; axonal fasciculation [GO:0007413]; neuron cell-cell adhesion [GO:0007158]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
O15397	reviewed	IPO8_HUMAN	Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8)	IPO8 RANBP8	Homo sapiens (Human)	1037	FUNCTION: Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:9214382). In vitro mediates the nuclear import of the signal recognition particle protein SRP19 (PubMed:11682607). May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines (Probable). {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9214382, ECO:0000305|PubMed:34010604}.		protein import into nucleus [GO:0006606]; signal transduction [GO:0007165]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]	small GTPase binding [GO:0031267]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; small GTPase binding [GO:0031267]; protein import into nucleus [GO:0006606]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
O15399	reviewed	NMDE4_HUMAN	Glutamate receptor ionotropic, NMDA 2D (GluN2D) (EB11) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D)	GRIN2D GluN2D NMDAR2D	Homo sapiens (Human)	1336	FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750). {ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:27616483, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:9489750}.		adult locomotory behavior [GO:0008344]; brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term synaptic potentiation [GO:0060291]; monoatomic cation transmembrane transport [GO:0098655]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic plasticity [GO:0048167]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]	endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]	glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; ionotropic glutamate receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; neurotransmitter binding [GO:0042165]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; voltage-gated monoatomic cation channel activity [GO:0022843]	endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]; glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; ionotropic glutamate receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; neurotransmitter binding [GO:0042165]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; voltage-gated monoatomic cation channel activity [GO:0022843]; adult locomotory behavior [GO:0008344]; brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term synaptic potentiation [GO:0060291]; monoatomic cation transmembrane transport [GO:0098655]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic plasticity [GO:0048167]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:9489750}; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
O15400	reviewed	STX7_HUMAN	Syntaxin-7	STX7	Homo sapiens (Human)	261	FUNCTION: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.		intracellular protein transport [GO:0006886]; organelle assembly [GO:0070925]; organelle localization [GO:0051640]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	azurophil granule [GO:0042582]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; tertiary granule [GO:0070820]; vesicle [GO:0031982]	chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]	azurophil granule [GO:0042582]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; tertiary granule [GO:0070820]; vesicle [GO:0031982]; chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; intracellular protein transport [GO:0006886]; organelle assembly [GO:0070925]; organelle localization [GO:0051640]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
O15405	reviewed	TOX3_HUMAN	TOX high mobility group box family member 3 (CAG trinucleotide repeat-containing gene F9 protein) (Trinucleotide repeat-containing gene 9 protein)	TOX3 CAGF9 TNRC9	Homo sapiens (Human)	576	FUNCTION: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. {ECO:0000269|PubMed:21172805}.		apoptotic process [GO:0006915]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; apoptotic process [GO:0006915]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O15409	reviewed	FOXP2_HUMAN	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein)	FOXP2 CAGH44 TNRC10	Homo sapiens (Human)	715	FUNCTION: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.		caudate nucleus development [GO:0021757]; cerebral cortex development [GO:0021987]; negative regulation of DNA-templated transcription [GO:0045892]; putamen development [GO:0021758]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; caudate nucleus development [GO:0021757]; cerebral cortex development [GO:0021987]; negative regulation of DNA-templated transcription [GO:0045892]; putamen development [GO:0021758]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O15427	reviewed	MOT4_HUMAN	Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3)	SLC16A3 MCT3 MCT4	Homo sapiens (Human)	465	FUNCTION: Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (PubMed:11101640, PubMed:23935841, PubMed:31719150). Plays a predominant role in L-lactate efflux from highly glycolytic cells (By similarity). {ECO:0000250|UniProtKB:O35910, ECO:0000269|PubMed:11101640, ECO:0000269|PubMed:23935841, ECO:0000269|PubMed:31719150}.		lactate transmembrane transport [GO:0035873]; monocarboxylic acid transport [GO:0015718]; protein catabolic process [GO:0030163]; pyruvate catabolic process [GO:0042867]; pyruvate transmembrane transport [GO:1901475]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; synapse [GO:0045202]	lactate:proton symporter activity [GO:0015650]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; pyruvate transmembrane transporter activity [GO:0050833]; RNA binding [GO:0003723]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; synapse [GO:0045202]; lactate:proton symporter activity [GO:0015650]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; pyruvate transmembrane transporter activity [GO:0050833]; RNA binding [GO:0003723]; lactate transmembrane transport [GO:0035873]; monocarboxylic acid transport [GO:0015718]; protein catabolic process [GO:0030163]; pyruvate catabolic process [GO:0042867]; pyruvate transmembrane transport [GO:1901475]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10921872, ECO:0000269|PubMed:11101640, ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:23935841}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:21199217}; Multi-pass membrane protein {ECO:0000255}. Note=Plasma membrane localization is dependent upon the BSG/MCT4 interaction (PubMed:10921872). Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression in polarised epithelial cells (PubMed:21199217). {ECO:0000269|PubMed:10921872, ECO:0000269|PubMed:21199217}.
O15431	reviewed	COPT1_HUMAN	High affinity copper uptake protein 1 (Copper transporter 1) (hCTR1) (Solute carrier family 31 member 1) [Cleaved into: Truncated CTR1 form]	SLC31A1 COPT1 CTR1	Homo sapiens (Human)	190	FUNCTION: [High affinity copper uptake protein 1]: Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane (PubMed:11734551, PubMed:16135512, PubMed:17525160, PubMed:19740744, PubMed:20451502, PubMed:20569931, PubMed:23658018) and delivers directly copper(1+) to specific chaperone such as ATOX1, via a copper(1+)- mediated transient interaction between the C-terminal domain and a copper(1+) chaperone, thus controlling intracellular copper(1+) levels (PubMed:26745413, PubMed:11734551, PubMed:17525160, PubMed:20451502, PubMed:19740744, PubMed:16135512, PubMed:23658018, PubMed:20569931). May function in copper(1+) import from the apical membrane thus may drive intestinal copper absorption (By similarity). The copper(1+) transport mechanism is sodium-independent, saturable and of high-affinity (PubMed:11734551). Also mediates the uptake of silver(1+) (PubMed:20569931). May function in the influx of the platinum-containing chemotherapeutic agents (PubMed:20451502, PubMed:20569931). The platinum-containing chemotherapeutic agents uptake is saturable (By similarity). In vitro, mediates the transport of cadmium(2+) into cells (PubMed:33294387). Also participates in the first step of copper(2+) acquisition by cells through a direct transfer of copper(2+) from copper(2+) carriers in blood, such as ALB to the N-terminal domain of SLC31A1, leading to copper(2+) reduction and probably followed by copper(1+) stabilization (PubMed:30489586). In addition, functions as a redox sensor to promote angiogenesis in endothelial cells, in a copper(1+) transport independent manner, by transmitting the VEGF-induced ROS signal through a sulfenylation at Cys-189 leadin g to a subsequent disulfide bond formation between SLC31A1 and KDR (PubMed:35027734). The SLC31A1-KDR complex is then co-internalized to early endosomes, driving a sustained VEGFR2 signaling (PubMed:35027734). {ECO:0000250|UniProtKB:Q8K211, ECO:0000250|UniProtKB:Q9JK41, ECO:0000269|PubMed:11734551, ECO:0000269|PubMed:16135512, ECO:0000269|PubMed:17525160, ECO:0000269|PubMed:19740744, ECO:0000269|PubMed:20451502, ECO:0000269|PubMed:20569931, ECO:0000269|PubMed:23658018, ECO:0000269|PubMed:26745413, ECO:0000269|PubMed:30489586, ECO:0000269|PubMed:33294387, ECO:0000269|PubMed:35027734}.; FUNCTION: [Truncated CTR1 form]: Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells. {ECO:0000250|UniProtKB:Q8K211}.		angiogenesis [GO:0001525]; copper ion import [GO:0015677]; copper ion transport [GO:0006825]; establishment of localization in cell [GO:0051649]; intracellular copper ion homeostasis [GO:0006878]; plasma membrane copper ion transport [GO:0015679]; protein complex oligomerization [GO:0051259]; silver ion transmembrane transport [GO:1902601]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; xenobiotic transport [GO:0042908]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; early endosome membrane [GO:0031901]; intercalated disc [GO:0014704]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; identical protein binding [GO:0042802]; silver ion transmembrane transporter activity [GO:0015080]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; early endosome membrane [GO:0031901]; intercalated disc [GO:0014704]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; identical protein binding [GO:0042802]; silver ion transmembrane transporter activity [GO:0015080]; xenobiotic transmembrane transporter activity [GO:0042910]; angiogenesis [GO:0001525]; copper ion import [GO:0015677]; copper ion transport [GO:0006825]; establishment of localization in cell [GO:0051649]; intracellular copper ion homeostasis [GO:0006878]; plasma membrane copper ion transport [GO:0015679]; protein complex oligomerization [GO:0051259]; silver ion transmembrane transport [GO:1902601]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11734551, ECO:0000269|PubMed:12023893, ECO:0000269|PubMed:15326162, ECO:0000269|PubMed:17525160, ECO:0000269|PubMed:20451502, ECO:0000269|PubMed:26205368, ECO:0000269|PubMed:26945057, ECO:0000269|PubMed:35913762}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:26945057}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:26945057}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q8K211}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q8K211}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8K211}; Multi-pass membrane protein {ECO:0000255}. Note=The localization is controlled by the intra and extra-cellular copper concentration (PubMed:19740744, PubMed:15326162, PubMed:26205368, PubMed:23658018, PubMed:26945057). Under conditions of elevated extracellular copper concentrations, it is rapidly internalized by endocytosis from the plasma membrane by a clathrin- and dynamin-mediated process and degradated in order to prevent intracellular copper accumulation and to reduce the transport of the copper across the membrane (PubMed:19740744, PubMed:15326162, PubMed:26205368, PubMed:23658018, PubMed:26945057). The internalized SLC31A1 is then localized in early endosomes, and, upon a low extracellular copper concentrations, it is transported back to the plasma membrane in a RAB11A-dependent recycling pathway (PubMed:26945057). Localizes to the apical membrane in intestinal epithelial cells (By similarity). Mainly localized on the basolateral side of renal tubular cells (By similarity). Localizes to the neuronal cell body plasma membranes (By similarity). {ECO:0000250|UniProtKB:Q8K211, ECO:0000250|UniProtKB:Q9JK41, ECO:0000269|PubMed:15326162, ECO:0000269|PubMed:19740744, ECO:0000269|PubMed:23658018, ECO:0000269|PubMed:26205368, ECO:0000269|PubMed:26945057}.
O15432	reviewed	COPT2_HUMAN	Protein SLC31A2 (Copper transporter 2) (hCTR2) (Solute carrier family 31 member 2)	SLC31A2 COPT2 CTR2	Homo sapiens (Human)	143	FUNCTION: Does not function as a copper(1+) importer in vivo (By similarity). However, in vitro functions as low-affinity copper(1+) importer (PubMed:17944601, PubMed:17617060). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (By similarity). {ECO:0000250|UniProtKB:Q9CPU9, ECO:0000269|PubMed:17617060, ECO:0000269|PubMed:17944601}.		copper ion import [GO:0015677]; copper ion transport [GO:0006825]; intracellular copper ion homeostasis [GO:0006878]; regulation of copper ion transmembrane transport [GO:1902311]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	copper ion transmembrane transporter activity [GO:0005375]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; copper ion transmembrane transporter activity [GO:0005375]; copper ion import [GO:0015677]; copper ion transport [GO:0006825]; intracellular copper ion homeostasis [GO:0006878]; regulation of copper ion transmembrane transport [GO:1902311]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17944601}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17944601}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:17617060}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17617060}; Multi-pass membrane protein {ECO:0000255}. Note=Plasma membrane localization is partial. {ECO:0000269|PubMed:17944601}.
O15438	reviewed	MRP3_HUMAN	ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3)	ABCC3 CMOAT2 MLP2 MRP3	Homo sapiens (Human)	1527	FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066, ECO:0000305|PubMed:35307651}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	bile acid and bile salt transport [GO:0015721]; leukotriene transport [GO:0071716]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; glucuronoside transmembrane transporter activity [GO:0015164]; icosanoid transmembrane transporter activity [GO:0071714]; xenobiotic transmembrane transporter activity [GO:0042910]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; glucuronoside transmembrane transporter activity [GO:0015164]; icosanoid transmembrane transporter activity [GO:0071714]; xenobiotic transmembrane transporter activity [GO:0042910]; bile acid and bile salt transport [GO:0015721]; leukotriene transport [GO:0071716]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:10094960, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:15083066, ECO:0000269|PubMed:28408210}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the basolateral membrane of enterocytes (PubMed:28408210). Localized to the basal membrane of Sertoli cells (PubMed:35307651). {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:35307651}.
O15439	reviewed	MRP4_HUMAN	ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4)	ABCC4 MOATB MRP4	Homo sapiens (Human)	1325	FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}.		bile acid and bile salt transport [GO:0015721]; cAMP transport [GO:0070730]; cilium assembly [GO:0060271]; export across plasma membrane [GO:0140115]; leukotriene transport [GO:0071716]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; prostaglandin transport [GO:0015732]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; urate transport [GO:0015747]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; external side of apical plasma membrane [GO:0098591]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]	15-hydroxyprostaglandin dehydrogenase (NAD+) activity [GO:0016404]; ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; guanine nucleotide transmembrane transporter activity [GO:0001409]; prostaglandin transmembrane transporter activity [GO:0015132]; purine nucleotide transmembrane transporter activity [GO:0015216]; urate transmembrane transporter activity [GO:0015143]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; external side of apical plasma membrane [GO:0098591]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity [GO:0016404]; ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; guanine nucleotide transmembrane transporter activity [GO:0001409]; prostaglandin transmembrane transporter activity [GO:0015132]; purine nucleotide transmembrane transporter activity [GO:0015216]; urate transmembrane transporter activity [GO:0015143]; xenobiotic transmembrane transporter activity [GO:0042910]; bile acid and bile salt transport [GO:0015721]; cAMP transport [GO:0070730]; cilium assembly [GO:0060271]; export across plasma membrane [GO:0140115]; leukotriene transport [GO:0071716]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; prostaglandin transport [GO:0015732]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; urate transport [GO:0015747]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:26721430}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:26721430}; Multi-pass membrane protein {ECO:0000255}. Note=Its localization to the basolateral or apical membranes is tissue-dependent. {ECO:0000305|PubMed:26721430}.
O15440	reviewed	MRP5_HUMAN	ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11)	ABCC5 MRP5	Homo sapiens (Human)	1437	FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (PubMed:10893247, PubMed:15899835, PubMed:25964343, PubMed:17229149, PubMed:12695538, PubMed:12637526). Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061). Confers resistance to the antiviral agent PMEA (PubMed:12695538). Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated (PubMed:10840050, PubMed:15899835, PubMed:12435799, PubMed:12695538). Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity). {ECO:0000250|UniProtKB:Q9R1X5, ECO:0000269|PubMed:10840050, ECO:0000269|PubMed:10893247, ECO:0000269|PubMed:12435799, ECO:0000269|PubMed:12637526, ECO:0000269|PubMed:12695538, ECO:0000269|PubMed:15899835, ECO:0000269|PubMed:17229149, ECO:0000269|PubMed:24836561, ECO:0000269|PubMed:25964343, ECO:0000269|PubMed:26515061}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: Although other labs have confirmed the ability of ABCC5 to transport cGMP in an ATP-dependent manner, they obtained a much lower affinity for this substrate (PubMed:12637526, PubMed:12695538). The authors conclude that ABCC5 is a low-affinity cyclic nucleotide transporter a major function in cGMP excretion is unlikely (PubMed:12637526, PubMed:12695538). {ECO:0000269|PubMed:12637526, ECO:0000269|PubMed:12695538}.	cAMP transport [GO:0070730]; cGMP transport [GO:0070731]; export across plasma membrane [GO:0140115]; folate transmembrane transport [GO:0098838]; glutathione transmembrane transport [GO:0034775]; heme transmembrane transport [GO:0035351]; hyaluronan biosynthetic process [GO:0030213]; purine nucleotide transport [GO:0015865]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endosome membrane [GO:0010008]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carbohydrate derivative transmembrane transporter activity [GO:1901505]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; heme transmembrane transporter activity [GO:0015232]; macromolecule transmembrane transporter activity [GO:0022884]; organic anion transmembrane transporter activity [GO:0008514]; purine nucleotide transmembrane transporter activity [GO:0015216]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endosome membrane [GO:0010008]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carbohydrate derivative transmembrane transporter activity [GO:1901505]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; heme transmembrane transporter activity [GO:0015232]; macromolecule transmembrane transporter activity [GO:0022884]; organic anion transmembrane transporter activity [GO:0008514]; purine nucleotide transmembrane transporter activity [GO:0015216]; xenobiotic transmembrane transporter activity [GO:0042910]; cAMP transport [GO:0070730]; cGMP transport [GO:0070731]; export across plasma membrane [GO:0140115]; folate transmembrane transport [GO:0098838]; glutathione transmembrane transport [GO:0034775]; heme transmembrane transport [GO:0035351]; hyaluronan biosynthetic process [GO:0030213]; purine nucleotide transport [GO:0015865]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:24836561}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus lumen {ECO:0000269|PubMed:24836561}. Endosome membrane {ECO:0000269|PubMed:24836561}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9R1X5}. Apical cell membrane {ECO:0000269|PubMed:15501592}; Multi-pass membrane protein {ECO:0000255}. Note=In most cells, routes to the basolateral plasma membrane, but in the brain capillary endothelial cells that form the blood-brain barrier, resides in the apical membrane. {ECO:0000269|PubMed:15501592, ECO:0000269|PubMed:24836561}.
O15444	reviewed	CCL25_HUMAN	C-C motif chemokine 25 (Chemokine TECK) (Small-inducible cytokine A25) (Thymus-expressed chemokine)	CCL25 SCYA25 TECK	Homo sapiens (Human)	150	FUNCTION: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; negative regulation of leukocyte tethering or rolling [GO:1903237]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR10 chemokine receptor binding [GO:0031735]; chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]; hormone activity [GO:0005179]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR10 chemokine receptor binding [GO:0031735]; chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]; hormone activity [GO:0005179]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; negative regulation of leukocyte tethering or rolling [GO:1903237]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	SUBCELLULAR LOCATION: Secreted.
O15446	reviewed	RPA34_HUMAN	DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49)	POLR1G ASE1 CAST CD3EAP PAF49	Homo sapiens (Human)	510	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation.; FUNCTION: Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex.	MISCELLANEOUS: It is in an antisense orientation to and overlaps the gene of the DNA repair enzyme ERCC1. This gene overlap is conserved in mouse, suggesting an important biological function.; MISCELLANEOUS: [Isoform 2]: Has sharply different functional characteristics. {ECO:0000305}.	rRNA transcription [GO:0009303]; transcription by RNA polymerase I [GO:0006360]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	chromosome [GO:0005694]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]; RNA polymerase I transcription regulator complex [GO:0000120]	RNA binding [GO:0003723]	chromosome [GO:0005694]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]; RNA polymerase I transcription regulator complex [GO:0000120]; RNA binding [GO:0003723]; rRNA transcription [GO:0009303]; transcription by RNA polymerase I [GO:0006360]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:9426281}. Chromosome {ECO:0000269|PubMed:9426281}. Note=Found at the fibrillar centers of the nucleolus in interphase and during cell division it is localized to the nucleolus organizer regions of the chromosomes.
O15455	reviewed	TLR3_HUMAN	Toll-like receptor 3 (CD antigen CD283)	TLR3	Homo sapiens (Human)	904	FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:16144834, ECO:0000269|PubMed:16720699, ECO:0000269|PubMed:16858407, ECO:0000269|PubMed:17178723, ECO:0000269|PubMed:18172197, ECO:0000269|PubMed:22611194}.		activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to mechanical stimulus [GO:0071260]; cellular response to type II interferon [GO:0071346]; cellular response to virus [GO:0098586]; cellular response to xenobiotic stimulus [GO:0071466]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; extrinsic apoptotic signaling pathway [GO:0097191]; hyperosmotic response [GO:0006972]; I-kappaB phosphorylation [GO:0007252]; inflammatory response to wounding [GO:0090594]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; male gonad development [GO:0008584]; microglial cell activation [GO:0001774]; necroptotic signaling pathway [GO:0097527]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of type III interferon production [GO:0034346]; regulation of dendritic cell cytokine production [GO:0002730]; response to dsRNA [GO:0043331]; response to exogenous dsRNA [GO:0043330]; signal transduction [GO:0007165]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor signaling pathway [GO:0002224]; type III interferon production [GO:0034343]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to mechanical stimulus [GO:0071260]; cellular response to type II interferon [GO:0071346]; cellular response to virus [GO:0098586]; cellular response to xenobiotic stimulus [GO:0071466]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; extrinsic apoptotic signaling pathway [GO:0097191]; hyperosmotic response [GO:0006972]; I-kappaB phosphorylation [GO:0007252]; inflammatory response to wounding [GO:0090594]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; male gonad development [GO:0008584]; microglial cell activation [GO:0001774]; necroptotic signaling pathway [GO:0097527]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of type III interferon production [GO:0034346]; regulation of dendritic cell cytokine production [GO:0002730]; response to dsRNA [GO:0043331]; response to exogenous dsRNA [GO:0043330]; signal transduction [GO:0007165]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor signaling pathway [GO:0002224]; type III interferon production [GO:0034343]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome {ECO:0000269|PubMed:25736436}.
O15457	reviewed	MSH4_HUMAN	MutS protein homolog 4 (hMSH4)	MSH4	Homo sapiens (Human)	936	FUNCTION: Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.		female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; mismatch repair [GO:0006298]; ovarian follicle development [GO:0001541]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]	chromosome [GO:0005694]; nucleus [GO:0005634]; recombination nodule [GO:0005713]; synaptonemal complex [GO:0000795]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; mismatched DNA binding [GO:0030983]	chromosome [GO:0005694]; nucleus [GO:0005634]; recombination nodule [GO:0005713]; synaptonemal complex [GO:0000795]; ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; mismatched DNA binding [GO:0030983]; female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; mismatch repair [GO:0006298]; ovarian follicle development [GO:0001541]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q99MT2}.
O15460	reviewed	P4HA2_HUMAN	Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)	P4HA2 UNQ290/PRO330	Homo sapiens (Human)	535	FUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:9211872}.			cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
O15466	reviewed	SIA8E_HUMAN	Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-) (Sialyltransferase 8E) (SIAT8-E) (Sialyltransferase St8Sia V) (ST8SiaV)	ST8SIA5 SIAT8E	Homo sapiens (Human)	376	FUNCTION: Involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, GP1c and GT3 from GD1a, GT1b, GM1b and GD3 respectively. {ECO:0000269|PubMed:9199191}.		carbohydrate metabolic process [GO:0005975]; glycosphingolipid biosynthetic process [GO:0006688]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]	Golgi membrane [GO:0000139]	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialyltransferase activity [GO:0008373]	Golgi membrane [GO:0000139]; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialyltransferase activity [GO:0008373]; carbohydrate metabolic process [GO:0005975]; glycosphingolipid biosynthetic process [GO:0006688]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6ZXC8}; Single-pass type II membrane protein {ECO:0000255}.
O15467	reviewed	CCL16_HUMAN	C-C motif chemokine 16 (Chemokine CC-4) (HCC-4) (Chemokine LEC) (IL-10-inducible chemokine) (LCC-1) (Liver-expressed chemokine) (Lymphocyte and monocyte chemoattractant) (LMC) (Monotactin-1) (MTN-1) (NCC-4) (Small-inducible cytokine A16)	CCL16 ILINCK NCC4 SCYA16	Homo sapiens (Human)	120	FUNCTION: Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.		cell communication [GO:0007154]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; cell communication [GO:0007154]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	SUBCELLULAR LOCATION: Secreted.
O15479	reviewed	MAGB2_HUMAN	Melanoma-associated antigen B2 (Cancer/testis antigen 3.2) (CT3.2) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2 antigen) (MAGE-B2 antigen)	MAGEB2	Homo sapiens (Human)	319	FUNCTION: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
O15481	reviewed	MAGB4_HUMAN	Melanoma-associated antigen B4 (MAGE-B4 antigen)	MAGEB4	Homo sapiens (Human)	346			negative regulation of transcription by RNA polymerase II [GO:0000122]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2A9R3}.
O15484	reviewed	CAN5_HUMAN	Calpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3)	CAPN5 NCL3	Homo sapiens (Human)	640	FUNCTION: Calcium-regulated non-lysosomal thiol-protease. {ECO:0000250}.		proteolysis [GO:0006508]; signal transduction [GO:0007165]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; synapse [GO:0045202]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; synapse [GO:0045202]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; proteolysis [GO:0006508]; signal transduction [GO:0007165]	
O15488	reviewed	GLYG2_HUMAN	Glycogenin-2 (GN-2) (GN2) (EC 2.4.1.186)	GYG2	Homo sapiens (Human)	501	FUNCTION: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. {ECO:0000269|PubMed:9346895, ECO:0000269|PubMed:9857012}.		glycogen biosynthetic process [GO:0005978]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	glycogenin glucosyltransferase activity [GO:0008466]; glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872]; UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity [GO:0102751]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glycogenin glucosyltransferase activity [GO:0008466]; glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872]; UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity [GO:0102751]; glycogen biosynthetic process [GO:0005978]	
O15492	reviewed	RGS16_HUMAN	Regulator of G-protein signaling 16 (RGS16) (A28-RGS14P) (Retinal-specific RGS) (RGS-r) (hRGS-r) (Retinally abundant regulator of G-protein signaling)	RGS16 RGSR	Homo sapiens (Human)	202	FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity). {ECO:0000250|UniProtKB:P97428, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:18434541}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P97428}; Lipid-anchor {ECO:0000250|UniProtKB:P97428}.
O15496	reviewed	PA2GX_HUMAN	Group 10 secretory phospholipase A2 (EC 3.1.1.4) (Group X secretory phospholipase A2) (GX sPLA2) (sPLA2-X) (Phosphatidylcholine 2-acylhydrolase 10)	PLA2G10	Homo sapiens (Human)	165	FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:9188469, PubMed:12021277). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls (PubMed:12359733, PubMed:12021277). Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles (PubMed:12021277). Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (PubMed:12021277). Efficiently hydrolyzes and inactivates platelet activating factor (PAF), a potent lipid mediator present in oxidized LDL (PubMed:16962371). May act in an autocrine and paracrine manner. Secreted by lung epithelium, targets membrane phospholipids of infiltrating eosinophils, releasing arachidonate and boosting eicosanoid and cysteinyl leukotriene synthesis involved in airway inflammatory response (By similarity). Secreted by gut epithelium, hydrolyzes dietary and biliary phosphatidylcholines in the gastrointestinal lumen (By similarity). Plays a stem cell regulator role in colon epithelium. Within intracellular compartment, mediates Paneth-like cell differentiation and its stem cell supporting functions by inhibiting the Wnt signaling pathway in intestinal stem cell (ISC). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ISCs and tissue regeneration (By similarity). May participate in hair follicle morphogenesis by regulating phosphatidylethanolamines metabolism at the outermost epithelial layer and facilitating melanin synthesis (By similarity). By releasing lysophosphatidylcholines (LPCs) at sperm acrosome, controls sperm cell capacitation, acrosome reaction and overall fertility (By similarity). May promote neurite outgrowth in neuron fibers involved in nociception (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (PubMed:12359733). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). In pulmonary epithelium, may contribute to host defense response against adenoviral infection. Prevents adenovirus entry into host cells by hydrolyzing host cell plasma membrane, releasing C16:0 LPCs that inhibit virus-mediated membrane fusion and viral infection. Likely prevents adenoviral entry into the endosomes of host cells (PubMed:16146426). May play a role in maturation and activation of innate immune cells including macrophages, group 2 innate lymphoid cells and mast cells (By similarity). {ECO:0000250|UniProtKB:Q9QXX3, ECO:0000269|PubMed:11694541, ECO:0000269|PubMed:12021277, ECO:0000269|PubMed:12359733, ECO:0000269|PubMed:16146426, ECO:0000269|PubMed:16962371, ECO:0000269|PubMed:9188469}.		arachidonic acid metabolic process [GO:0019369]; arachidonic acid secretion [GO:0050482]; axon guidance [GO:0007411]; cellular response to leukemia inhibitory factor [GO:1990830]; cholesterol homeostasis [GO:0042632]; defense response to virus [GO:0051607]; erythrocyte maturation [GO:0043249]; fertilization [GO:0009566]; hair follicle morphogenesis [GO:0031069]; intestinal stem cell homeostasis [GO:0036335]; low-density lipoprotein particle remodeling [GO:0034374]; lysophospholipid transport [GO:0051977]; macrophage activation [GO:0042116]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of inflammatory response [GO:0050728]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644]; platelet activating factor catabolic process [GO:0062234]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein metabolic process [GO:0051247]; production of molecular mediator involved in inflammatory response [GO:0002532]; prostaglandin biosynthetic process [GO:0001516]; regulation of macrophage activation [GO:0043030]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipase activity [GO:0004620]; phospholipid binding [GO:0005543]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipase activity [GO:0004620]; phospholipid binding [GO:0005543]; arachidonic acid metabolic process [GO:0019369]; arachidonic acid secretion [GO:0050482]; axon guidance [GO:0007411]; cellular response to leukemia inhibitory factor [GO:1990830]; cholesterol homeostasis [GO:0042632]; defense response to virus [GO:0051607]; erythrocyte maturation [GO:0043249]; fertilization [GO:0009566]; hair follicle morphogenesis [GO:0031069]; intestinal stem cell homeostasis [GO:0036335]; low-density lipoprotein particle remodeling [GO:0034374]; lysophospholipid transport [GO:0051977]; macrophage activation [GO:0042116]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of inflammatory response [GO:0050728]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644]; platelet activating factor catabolic process [GO:0062234]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein metabolic process [GO:0051247]; production of molecular mediator involved in inflammatory response [GO:0002532]; prostaglandin biosynthetic process [GO:0001516]; regulation of macrophage activation [GO:0043030]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9188469}. Lysosome {ECO:0000250|UniProtKB:Q9QXX3}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9QXX3}.
O15498	reviewed	YKT6_HUMAN	Synaptobrevin homolog YKT6 (EC 2.3.1.-)	YKT6	Homo sapiens (Human)	198	FUNCTION: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:9211930}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking involved in exocytosis [GO:0006904]; vesicle targeting [GO:0006903]	apical dendrite [GO:0097440]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133]	cadherin binding [GO:0045296]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; SNAP receptor activity [GO:0005484]	apical dendrite [GO:0097440]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133]; cadherin binding [GO:0045296]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; SNAP receptor activity [GO:0005484]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking involved in exocytosis [GO:0006904]; vesicle targeting [GO:0006903]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes.
O15499	reviewed	GSC2_HUMAN	Homeobox protein goosecoid-2 (GSC-2) (Homeobox protein goosecoid-like) (GSC-L)	GSC2 GSCL	Homo sapiens (Human)	205	FUNCTION: May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC.		anatomical structure morphogenesis [GO:0009653]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
O15503	reviewed	INSI1_HUMAN	Insulin-induced gene 1 protein (INSIG-1)	INSIG1	Homo sapiens (Human)	277	FUNCTION: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}.		cellular response to insulin stimulus [GO:0032869]; cellular response to sterol [GO:0036315]; cholesterol biosynthetic process [GO:0006695]; cholesterol homeostasis [GO:0042632]; cranial suture morphogenesis [GO:0060363]; inner ear morphogenesis [GO:0042472]; middle ear morphogenesis [GO:0042474]; negative regulation of cargo loading into COPII-coated vesicle [GO:1901303]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of protein exit from endoplasmic reticulum [GO:0070862]; negative regulation of steroid biosynthetic process [GO:0010894]; roof of mouth development [GO:0060021]; SREBP signaling pathway [GO:0032933]; SREBP-SCAP complex retention in endoplasmic reticulum [GO:0036316]; triglyceride metabolic process [GO:0006641]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SREBP-SCAP-Insig complex [GO:0032937]	oxysterol binding [GO:0008142]; protein sequestering activity [GO:0140311]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SREBP-SCAP-Insig complex [GO:0032937]; oxysterol binding [GO:0008142]; protein sequestering activity [GO:0140311]; cellular response to insulin stimulus [GO:0032869]; cellular response to sterol [GO:0036315]; cholesterol biosynthetic process [GO:0006695]; cholesterol homeostasis [GO:0042632]; cranial suture morphogenesis [GO:0060363]; inner ear morphogenesis [GO:0042472]; middle ear morphogenesis [GO:0042474]; negative regulation of cargo loading into COPII-coated vesicle [GO:1901303]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of protein exit from endoplasmic reticulum [GO:0070862]; negative regulation of steroid biosynthetic process [GO:0010894]; roof of mouth development [GO:0060021]; SREBP signaling pathway [GO:0032933]; SREBP-SCAP complex retention in endoplasmic reticulum [GO:0036316]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:32322062}; Multi-pass membrane protein {ECO:0000269|PubMed:12202038}.
O15504	reviewed	NUP42_HUMAN	Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2)	NUP42 CG1 NUPL2	Homo sapiens (Human)	423	FUNCTION: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. {ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:16000379}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. {ECO:0000269|PubMed:12228227}.		mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; nuclear export signal receptor activity [GO:0005049]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; nuclear export signal receptor activity [GO:0005049]; RNA binding [GO:0003723]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:12228227, ECO:0000269|PubMed:16000379}. Nucleus membrane {ECO:0000269|PubMed:12228227, ECO:0000269|PubMed:16000379}; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:12228227}. Note=Excluded from the nucleolus. {ECO:0000269|PubMed:10358091}.
O15511	reviewed	ARPC5_HUMAN	Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)	ARPC5 ARC16	Homo sapiens (Human)	151	FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.		actin cytoskeleton organization [GO:0030036]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell migration [GO:0016477]; regulation of actin filament polymerization [GO:0030833]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; site of double-strand break [GO:0035861]	actin binding [GO:0003779]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; site of double-strand break [GO:0035861]; actin binding [GO:0003779]; structural constituent of cytoskeleton [GO:0005200]; actin cytoskeleton organization [GO:0030036]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell migration [GO:0016477]; regulation of actin filament polymerization [GO:0030833]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9230079}. Cell projection {ECO:0000269|PubMed:9230079}. Nucleus {ECO:0000269|PubMed:29925947}.
O15514	reviewed	RPB4_HUMAN	DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16)	POLR2D	Homo sapiens (Human)	142	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RPB4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.		recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [GO:0034402]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]	nucleotide binding [GO:0000166]; translation initiation factor binding [GO:0031369]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; nucleotide binding [GO:0000166]; translation initiation factor binding [GO:0031369]; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [GO:0034402]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
O15516	reviewed	CLOCK_HUMAN	Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8)	CLOCK BHLHE8 KIAA0334	Homo sapiens (Human)	846	FUNCTION: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.	MISCELLANEOUS: CLOCK-BMAL1 double mutations within the PAS domains result in synergistic desensitization to high levels of CRY on repression of CLOCK-BMAL1 transcriptional activity of PER1 and disrupt circadian rhythmicity.	cellular response to ionizing radiation [GO:0071479]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA damage checkpoint signaling [GO:0000077]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; photoperiodism [GO:0009648]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of inflammatory response [GO:0050729]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein acetylation [GO:0006473]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of hair cycle [GO:0042634]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell development [GO:2000074]; response to redox state [GO:0051775]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; chromatoid body [GO:0033391]; chromosome [GO:0005694]; CLOCK-BMAL transcription complex [GO:1990513]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; histone acetyltransferase activity [GO:0004402]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; chromatoid body [GO:0033391]; chromosome [GO:0005694]; CLOCK-BMAL transcription complex [GO:1990513]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; histone acetyltransferase activity [GO:0004402]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to ionizing radiation [GO:0071479]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA damage checkpoint signaling [GO:0000077]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; photoperiodism [GO:0009648]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of inflammatory response [GO:0050729]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein acetylation [GO:0006473]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of hair cycle [GO:0042634]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell development [GO:2000074]; response to redox state [GO:0051775]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:28985504}. Cytoplasm {ECO:0000250|UniProtKB:O08785}. Cytoplasm, cytosol {ECO:0000269|PubMed:28985504}. Note=Shuttling between the cytoplasm and the nucleus is under circadian regulation and is BMAL1-dependent. Phosphorylated form located in the nucleus while the nonphosphorylated form found only in the cytoplasm. Sequestered to the cytoplasm in the presence of ID2 (By similarity). Localizes to sites of DNA damage in a H2AX-independent manner. {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:21659603}.
O15519	reviewed	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]	CFLAR CASH CASP8AP1 CLARP MRIT	Homo sapiens (Human)	480	FUNCTION: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {ECO:0000269|PubMed:9880531}.	MISCELLANEOUS: [Isoform 9]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	apoptotic process [GO:0006915]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to nitric oxide [GO:0071732]; erythrocyte differentiation [GO:0030218]; keratinocyte differentiation [GO:0030216]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of myoblast fusion [GO:1901740]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron differentiation [GO:0030182]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteolysis [GO:0006508]; regulation of necroptotic process [GO:0060544]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; response to testosterone [GO:0033574]; skeletal muscle atrophy [GO:0014732]; skeletal muscle tissue development [GO:0007519]; skeletal muscle tissue regeneration [GO:0043403]; skeletal myofibril assembly [GO:0014866]; wound healing [GO:0042060]	CD95 death-inducing signaling complex [GO:0031265]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; ripoptosome [GO:0097342]	cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; death receptor binding [GO:0005123]; enzyme activator activity [GO:0008047]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]	CD95 death-inducing signaling complex [GO:0031265]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; ripoptosome [GO:0097342]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; death receptor binding [GO:0005123]; enzyme activator activity [GO:0008047]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; apoptotic process [GO:0006915]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to nitric oxide [GO:0071732]; erythrocyte differentiation [GO:0030218]; keratinocyte differentiation [GO:0030216]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of myoblast fusion [GO:1901740]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron differentiation [GO:0030182]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteolysis [GO:0006508]; regulation of necroptotic process [GO:0060544]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; response to testosterone [GO:0033574]; skeletal muscle atrophy [GO:0014732]; skeletal muscle tissue development [GO:0007519]; skeletal muscle tissue regeneration [GO:0043403]; skeletal myofibril assembly [GO:0014866]; wound healing [GO:0042060]	
O15520	reviewed	FGF10_HUMAN	Fibroblast growth factor 10 (FGF-10) (Keratinocyte growth factor 2)	FGF10	Homo sapiens (Human)	208	FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. {ECO:0000269|PubMed:16597617}.		actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; blood vessel remodeling [GO:0001974]; branch elongation involved in salivary gland morphogenesis [GO:0060667]; branching morphogenesis of an epithelial tube [GO:0048754]; bronchiole morphogenesis [GO:0060436]; bud elongation involved in lung branching [GO:0060449]; bud outgrowth involved in lung branching [GO:0060447]; cell differentiation [GO:0030154]; determination of left/right symmetry [GO:0007368]; embryonic camera-type eye development [GO:0031076]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic genitalia morphogenesis [GO:0030538]; embryonic pattern specification [GO:0009880]; endothelial cell proliferation [GO:0001935]; epithelial cell proliferation [GO:0050673]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; ERK1 and ERK2 cascade [GO:0070371]; establishment of mitotic spindle orientation [GO:0000132]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; female genitalia morphogenesis [GO:0048807]; fibroblast growth factor receptor signaling pathway involved in mammary gland specification [GO:0060595]; fibroblast proliferation [GO:0048144]; hair follicle morphogenesis [GO:0031069]; Harderian gland development [GO:0070384]; induction of positive chemotaxis [GO:0050930]; keratinocyte proliferation [GO:0043616]; lacrimal gland development [GO:0032808]; limb bud formation [GO:0060174]; limb development [GO:0060173]; lung epithelium development [GO:0060428]; lung proximal/distal axis specification [GO:0061115]; lung saccule development [GO:0060430]; male genitalia morphogenesis [GO:0048808]; mammary gland bud formation [GO:0060615]; mesenchymal cell differentiation involved in lung development [GO:0060915]; mesenchymal-epithelial cell signaling involved in lung development [GO:0060496]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; metanephros morphogenesis [GO:0003338]; muscle cell fate commitment [GO:0042693]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of stem cell proliferation [GO:2000647]; odontogenesis of dentin-containing tooth [GO:0042475]; organ induction [GO:0001759]; otic vesicle formation [GO:0030916]; pancreas development [GO:0031016]; pituitary gland development [GO:0021983]; positive chemotaxis [GO:0050918]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA repair [GO:0045739]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of hair follicle cell proliferation [GO:0071338]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of urothelial cell proliferation [GO:0050677]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of white fat cell proliferation [GO:0070352]; prostatic bud formation [GO:0060513]; protein localization to cell surface [GO:0034394]; radial glial cell differentiation [GO:0060019]; regulation of activin receptor signaling pathway [GO:0032925]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of saliva secretion [GO:0046877]; regulation of smoothened signaling pathway [GO:0008589]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; salivary gland development [GO:0007431]; secretion by lung epithelial cell involved in lung growth [GO:0061033]; semicircular canal fusion [GO:0060879]; smooth muscle cell differentiation [GO:0051145]; somatic stem cell population maintenance [GO:0035019]; spleen development [GO:0048536]; stem cell proliferation [GO:0072089]; submandibular salivary gland formation [GO:0060661]; tear secretion [GO:0070075]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; tissue regeneration [GO:0042246]; type II pneumocyte differentiation [GO:0060510]; urothelial cell proliferation [GO:0050674]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; white fat cell differentiation [GO:0050872]; white fat cell proliferation [GO:0070343]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	chemoattractant activity [GO:0042056]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; type 2 fibroblast growth factor receptor binding [GO:0005111]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; chemoattractant activity [GO:0042056]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; type 2 fibroblast growth factor receptor binding [GO:0005111]; actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; blood vessel remodeling [GO:0001974]; branch elongation involved in salivary gland morphogenesis [GO:0060667]; branching morphogenesis of an epithelial tube [GO:0048754]; bronchiole morphogenesis [GO:0060436]; bud elongation involved in lung branching [GO:0060449]; bud outgrowth involved in lung branching [GO:0060447]; cell differentiation [GO:0030154]; determination of left/right symmetry [GO:0007368]; embryonic camera-type eye development [GO:0031076]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic genitalia morphogenesis [GO:0030538]; embryonic pattern specification [GO:0009880]; endothelial cell proliferation [GO:0001935]; epithelial cell proliferation [GO:0050673]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; ERK1 and ERK2 cascade [GO:0070371]; establishment of mitotic spindle orientation [GO:0000132]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; female genitalia morphogenesis [GO:0048807]; fibroblast growth factor receptor signaling pathway involved in mammary gland specification [GO:0060595]; fibroblast proliferation [GO:0048144]; hair follicle morphogenesis [GO:0031069]; Harderian gland development [GO:0070384]; induction of positive chemotaxis [GO:0050930]; keratinocyte proliferation [GO:0043616]; lacrimal gland development [GO:0032808]; limb bud formation [GO:0060174]; limb development [GO:0060173]; lung epithelium development [GO:0060428]; lung proximal/distal axis specification [GO:0061115]; lung saccule development [GO:0060430]; male genitalia morphogenesis [GO:0048808]; mammary gland bud formation [GO:0060615]; mesenchymal cell differentiation involved in lung development [GO:0060915]; mesenchymal-epithelial cell signaling involved in lung development [GO:0060496]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; metanephros morphogenesis [GO:0003338]; muscle cell fate commitment [GO:0042693]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of stem cell proliferation [GO:2000647]; odontogenesis of dentin-containing tooth [GO:0042475]; organ induction [GO:0001759]; otic vesicle formation [GO:0030916]; pancreas development [GO:0031016]; pituitary gland development [GO:0021983]; positive chemotaxis [GO:0050918]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA repair [GO:0045739]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of hair follicle cell proliferation [GO:0071338]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of urothelial cell proliferation [GO:0050677]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of white fat cell proliferation [GO:0070352]; prostatic bud formation [GO:0060513]; protein localization to cell surface [GO:0034394]; radial glial cell differentiation [GO:0060019]; regulation of activin receptor signaling pathway [GO:0032925]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of saliva secretion [GO:0046877]; regulation of smoothened signaling pathway [GO:0008589]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; salivary gland development [GO:0007431]; secretion by lung epithelial cell involved in lung growth [GO:0061033]; semicircular canal fusion [GO:0060879]; smooth muscle cell differentiation [GO:0051145]; somatic stem cell population maintenance [GO:0035019]; spleen development [GO:0048536]; stem cell proliferation [GO:0072089]; submandibular salivary gland formation [GO:0060661]; tear secretion [GO:0070075]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; tissue regeneration [GO:0042246]; type II pneumocyte differentiation [GO:0060510]; urothelial cell proliferation [GO:0050674]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; white fat cell differentiation [GO:0050872]; white fat cell proliferation [GO:0070343]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O15522	reviewed	NKX28_HUMAN	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H)	NKX2-8 NKX-2.8 NKX2G NKX2H	Homo sapiens (Human)	239			axonogenesis [GO:0007409]; cell differentiation [GO:0030154]; DNA-templated transcription [GO:0006351]; epithelial cell proliferation [GO:0050673]; liver development [GO:0001889]; lung development [GO:0030324]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; axonogenesis [GO:0007409]; cell differentiation [GO:0030154]; DNA-templated transcription [GO:0006351]; epithelial cell proliferation [GO:0050673]; liver development [GO:0001889]; lung development [GO:0030324]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O15523	reviewed	DDX3Y_HUMAN	ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal)	DDX3Y DBY	Homo sapiens (Human)	660	FUNCTION: Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}.		cell differentiation [GO:0030154]; gamete generation [GO:0007276]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; cell differentiation [GO:0030154]; gamete generation [GO:0007276]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15294876, ECO:0000269|PubMed:15383328}. Nucleus {ECO:0000269|PubMed:15383328}. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.
O15524	reviewed	SOCS1_HUMAN	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)	SOCS1 SSI1 TIP3	Homo sapiens (Human)	211	FUNCTION: Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:32499645, PubMed:33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480). {ECO:0000250|UniProtKB:O35716, ECO:0000269|PubMed:11278610, ECO:0000269|PubMed:11313480, ECO:0000269|PubMed:32499645, ECO:0000269|PubMed:33087723, ECO:0000269|PubMed:9341160}.		cellular response to amino acid stimulus [GO:0071230]; cytokine-mediated signaling pathway [GO:0019221]; fat cell differentiation [GO:0045444]; intracellular signal transduction [GO:0035556]; macrophage differentiation [GO:0030225]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of regulatory T cell differentiation [GO:0045591]; protein ubiquitination [GO:0016567]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cytokine production [GO:0001817]; regulation of protein phosphorylation [GO:0001932]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase complex [GO:0005942]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; insulin-like growth factor receptor binding [GO:0005159]; kinase inhibitor activity [GO:0019210]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase complex [GO:0005942]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; insulin-like growth factor receptor binding [GO:0005159]; kinase inhibitor activity [GO:0019210]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; cellular response to amino acid stimulus [GO:0071230]; cytokine-mediated signaling pathway [GO:0019221]; fat cell differentiation [GO:0045444]; intracellular signal transduction [GO:0035556]; macrophage differentiation [GO:0030225]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of regulatory T cell differentiation [GO:0045591]; protein ubiquitination [GO:0016567]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cytokine production [GO:0001817]; regulation of protein phosphorylation [GO:0001932]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16410555}. Cytoplasmic vesicle {ECO:0000269|PubMed:16410555}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
O15525	reviewed	MAFG_HUMAN	Transcription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G) (hMAF)	MAFG	Homo sapiens (Human)	162	FUNCTION: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity). {ECO:0000250|UniProtKB:Q76MX4, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9421508}.		adult behavior [GO:0030534]; in utero embryonic development [GO:0001701]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; regulation of cell population proliferation [GO:0042127]; regulation of epidermal cell differentiation [GO:0045604]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; adult behavior [GO:0030534]; in utero embryonic development [GO:0001701]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; regulation of cell population proliferation [GO:0042127]; regulation of epidermal cell differentiation [GO:0045604]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:11154691}.
O15527	reviewed	OGG1_HUMAN	N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]	OGG1 MMH MUTM OGH1	Homo sapiens (Human)	345	FUNCTION: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.		base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; cellular response to cadmium ion [GO:0071276]; depurination [GO:0045007]; depyrimidination [GO:0045008]; DNA damage response [GO:0006974]; negative regulation of apoptotic process [GO:0043066]; negative regulation of double-strand break repair via single-strand annealing [GO:1901291]; nucleotide-excision repair [GO:0006289]; regulation of DNA-templated transcription [GO:0006355]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to light stimulus [GO:0009416]; response to oxidative stress [GO:0006979]; response to radiation [GO:0009314]; response to xenobiotic stimulus [GO:0009410]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; endonuclease activity [GO:0004519]; microtubule binding [GO:0008017]; oxidized purine DNA binding [GO:0032357]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; endonuclease activity [GO:0004519]; microtubule binding [GO:0008017]; oxidized purine DNA binding [GO:0032357]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534]; base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; cellular response to cadmium ion [GO:0071276]; depurination [GO:0045007]; depyrimidination [GO:0045008]; DNA damage response [GO:0006974]; negative regulation of apoptotic process [GO:0043066]; negative regulation of double-strand break repair via single-strand annealing [GO:1901291]; nucleotide-excision repair [GO:0006289]; regulation of DNA-templated transcription [GO:0006355]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to light stimulus [GO:0009416]; response to oxidative stress [GO:0006979]; response to radiation [GO:0009314]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17148573}. Nucleus speckle {ECO:0000269|PubMed:17148573}. Nucleus matrix {ECO:0000269|PubMed:17148573}. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.; SUBCELLULAR LOCATION: [Isoform 1A]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 2A]: Mitochondrion.
O15528	reviewed	CP27B_HUMAN	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (EC 1.14.15.18) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (Calcidiol 1-monooxygenase) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome P450C1 alpha) (Cytochrome P450VD1-alpha) (Cytochrome p450 27B1)	CYP27B1 CYP1ALPHA CYP27B	Homo sapiens (Human)	508	FUNCTION: A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1alpha-position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR) (PubMed:10518789, PubMed:9486994, PubMed:22862690, PubMed:10566658, PubMed:12050193). Has 1alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway (PubMed:10518789, PubMed:22862690). Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2 (PubMed:10518789). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:22862690). {ECO:0000269|PubMed:10518789, ECO:0000269|PubMed:10566658, ECO:0000269|PubMed:12050193, ECO:0000269|PubMed:22862690, ECO:0000269|PubMed:9486994}.		bone mineralization [GO:0030282]; calcitriol biosynthetic process from calciol [GO:0036378]; calcium ion homeostasis [GO:0055074]; calcium ion transport [GO:0006816]; decidualization [GO:0046697]; G1 to G0 transition [GO:0070314]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of vitamin D 24-hydroxylase activity [GO:0010980]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of bone mineralization [GO:0030500]; response to estrogen [GO:0043627]; response to lipopolysaccharide [GO:0032496]; response to type II interferon [GO:0034341]; response to vitamin D [GO:0033280]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; vitamin metabolic process [GO:0006766]	cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	calcidiol 1-monooxygenase activity [GO:0004498]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; secalciferol 1-monooxygenase activity [GO:0062185]	cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; calcidiol 1-monooxygenase activity [GO:0004498]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; secalciferol 1-monooxygenase activity [GO:0062185]; bone mineralization [GO:0030282]; calcitriol biosynthetic process from calciol [GO:0036378]; calcium ion homeostasis [GO:0055074]; calcium ion transport [GO:0006816]; decidualization [GO:0046697]; G1 to G0 transition [GO:0070314]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of vitamin D 24-hydroxylase activity [GO:0010980]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of bone mineralization [GO:0030500]; response to estrogen [GO:0043627]; response to lipopolysaccharide [GO:0032496]; response to type II interferon [GO:0034341]; response to vitamin D [GO:0033280]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; vitamin metabolic process [GO:0006766]	SUBCELLULAR LOCATION: Mitochondrion membrane.
O15529	reviewed	GPR42_HUMAN	G-protein coupled receptor 42	GPR42 GPR42P	Homo sapiens (Human)	346	FUNCTION: G protein-coupled receptor that is activated by short chain fatty acids (SCFAs), such as propionate. Hence may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity. {ECO:0000269|PubMed:19630535}.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
O15530	reviewed	PDPK1_HUMAN	3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)	PDPK1 PDK1	Homo sapiens (Human)	556	FUNCTION: Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive. {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.		actin cytoskeleton organization [GO:0030036]; activation of protein kinase B activity [GO:0032148]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to insulin stimulus [GO:0032869]; epidermal growth factor receptor signaling pathway [GO:0007173]; extrinsic apoptotic signaling pathway [GO:0097191]; hyperosmotic response [GO:0006972]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of mast cell degranulation [GO:0043304]; T cell costimulation [GO:0031295]; type B pancreatic cell development [GO:0003323]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	3-phosphoinositide-dependent protein kinase activity [GO:0004676]; ATP binding [GO:0005524]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; ATP binding [GO:0005524]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; actin cytoskeleton organization [GO:0030036]; activation of protein kinase B activity [GO:0032148]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to insulin stimulus [GO:0032869]; epidermal growth factor receptor signaling pathway [GO:0007173]; extrinsic apoptotic signaling pathway [GO:0097191]; hyperosmotic response [GO:0006972]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of mast cell degranulation [GO:0043304]; T cell costimulation [GO:0031295]; type B pancreatic cell development [GO:0003323]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Cell junction, focal adhesion. Note=Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90 promote its localization to the cell membrane. Its nuclear localization is dependent on its association with PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells it is found in the cytoplasm. The Ser-241 phosphorylated form is distributed along the perinuclear region in neuronal cells while in non-neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II stimulation.
O15533	reviewed	TPSN_HUMAN	Tapasin (TPN) (TPSN) (NGS-17) (TAP-associated protein) (TAP-binding protein)	TAPBP NGS17 TAPA	Homo sapiens (Human)	448	FUNCTION: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). {ECO:0000269|PubMed:10636848, ECO:0000269|PubMed:12582157, ECO:0000269|PubMed:21263072, ECO:0000269|PubMed:26611325}.	MISCELLANEOUS: [Isoform 2]: Due to a partial intron retention. {ECO:0000305}.	antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; MHC class Ib protein complex assembly [GO:0002398]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; peptide antigen stabilization [GO:0050823]; protein-containing complex assembly [GO:0065003]; regulation of gene expression [GO:0010468]; regulation of protein complex stability [GO:0061635]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I peptide loading complex [GO:0042824]; phagocytic vesicle membrane [GO:0030670]; Tapasin-ERp57 complex [GO:0061779]	MHC class I protein binding [GO:0042288]; MHC class I protein complex binding [GO:0023024]; molecular adaptor activity [GO:0060090]; peptide antigen binding [GO:0042605]; TAP complex binding [GO:0062061]; TAP1 binding [GO:0046978]; TAP2 binding [GO:0046979]; unfolded protein binding [GO:0051082]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I peptide loading complex [GO:0042824]; phagocytic vesicle membrane [GO:0030670]; Tapasin-ERp57 complex [GO:0061779]; MHC class I protein binding [GO:0042288]; MHC class I protein complex binding [GO:0023024]; molecular adaptor activity [GO:0060090]; peptide antigen binding [GO:0042605]; TAP complex binding [GO:0062061]; TAP1 binding [GO:0046978]; TAP2 binding [GO:0046979]; unfolded protein binding [GO:0051082]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; MHC class Ib protein complex assembly [GO:0002398]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; peptide antigen stabilization [GO:0050823]; protein-containing complex assembly [GO:0065003]; regulation of gene expression [GO:0010468]; regulation of protein complex stability [GO:0061635]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O15534	reviewed	PER1_HUMAN	Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)	PER1 KIAA0482 PER RIGUI	Homo sapiens (Human)	1290	FUNCTION: Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}.		chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; circadian regulation of translation [GO:0097167]; circadian rhythm [GO:0007623]; entrainment of circadian clock [GO:0009649]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of JNK cascade [GO:0046329]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of circadian rhythm [GO:0042752]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of hair cycle [GO:0042634]; regulation of p38MAPK cascade [GO:1900744]; regulation of sodium ion transport [GO:0002028]; response to cAMP [GO:0051591]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; kinase binding [GO:0019900]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; kinase binding [GO:0019900]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; circadian regulation of translation [GO:0097167]; circadian rhythm [GO:0007623]; entrainment of circadian clock [GO:0009649]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of JNK cascade [GO:0046329]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of circadian rhythm [GO:0042752]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of hair cycle [GO:0042634]; regulation of p38MAPK cascade [GO:1900744]; regulation of sodium ion transport [GO:0002028]; response to cAMP [GO:0051591]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2 (By similarity). {ECO:0000250}.
O15535	reviewed	ZSC9_HUMAN	Zinc finger and SCAN domain-containing protein 9 (Cell proliferation-inducing gene 12 protein) (PRD51) (Zinc finger protein 193)	ZSCAN9 ZNF193 PIG12	Homo sapiens (Human)	394	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
O15537	reviewed	XLRS1_HUMAN	Retinoschisin (X-linked juvenile retinoschisis protein)	RS1 XLRS1	Homo sapiens (Human)	224	FUNCTION: Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531). Required for normal structure and function of the retina (PubMed:19093009). {ECO:0000250|UniProtKB:Q9Z1L4, ECO:0000269|PubMed:19093009, ECO:0000305|PubMed:27114531}.		adaptation of rhodopsin mediated signaling [GO:0016062]; cell adhesion [GO:0007155]; eye development [GO:0001654]; protein homooligomerization [GO:0051260]; retina layer formation [GO:0010842]; visual perception [GO:0007601]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; neuron to neuron synapse [GO:0098984]; photoreceptor inner segment [GO:0001917]	phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylserine binding [GO:0001786]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; neuron to neuron synapse [GO:0098984]; photoreceptor inner segment [GO:0001917]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylserine binding [GO:0001786]; adaptation of rhodopsin mediated signaling [GO:0016062]; cell adhesion [GO:0007155]; eye development [GO:0001654]; protein homooligomerization [GO:0051260]; retina layer formation [GO:0010842]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10915776, ECO:0000269|PubMed:19849666, ECO:0000269|PubMed:26812435}. Cell membrane {ECO:0000250|UniProtKB:Q9Z1L4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z1L4}; Extracellular side {ECO:0000250|UniProtKB:Q9Z1L4}. Note=Binds to phosphatidylserine-containing lipid membranes and embeds itself partially into the lipid bilayer. Lipid-binding requires the presence of Ca(2+) ions. {ECO:0000250|UniProtKB:Q9Z1L4}.
O15540	reviewed	FABP7_HUMAN	Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) (Mammary-derived growth inhibitor related)	FABP7 BLBP FABPB MRG	Homo sapiens (Human)	132	FUNCTION: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity). {ECO:0000250}.		epithelial cell proliferation [GO:0050673]; fatty acid transport [GO:0015908]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]	cytosol [GO:0005829]; nucleus [GO:0005634]	fatty acid binding [GO:0005504]; lipid binding [GO:0008289]	cytosol [GO:0005829]; nucleus [GO:0005634]; fatty acid binding [GO:0005504]; lipid binding [GO:0008289]; epithelial cell proliferation [GO:0050673]; fatty acid transport [GO:0015908]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cytoplasm.
O15541	reviewed	R113A_HUMAN	E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183)	RNF113A RNF113 ZNF183	Homo sapiens (Human)	343	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:29361316, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524). {ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.		DNA repair [GO:0006281]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; protein ubiquitination [GO:0016567]; snoRNA splicing [GO:0034247]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; DNA repair [GO:0006281]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; protein ubiquitination [GO:0016567]; snoRNA splicing [GO:0034247]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316}. Nucleus speckle {ECO:0000269|PubMed:29144457}. Note=Colocalizes with ASCC2 in nuclear foci after DNA damage by alkylating agents. In the absence of DNA damage, colocalizes with the spliceosome components SNRNP200/BRR2 and PRPF8 in nuclear speckles. {ECO:0000269|PubMed:29144457}.
O15547	reviewed	P2RX6_HUMAN	P2X purinoceptor 6 (P2X6) (ATP receptor) (P2XM) (Purinergic receptor) (Purinergic receptor P2X-like 1)	P2RX6 P2RXL1 P2X6	Homo sapiens (Human)	441	FUNCTION: Receptor for ATP that acts as a ligand-gated ion channel. {ECO:0000250}.		calcium ion transmembrane transport [GO:0070588]; muscle contraction [GO:0006936]; response to ATP [GO:0033198]; signal transduction [GO:0007165]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; channel activity [GO:0015267]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; protein-containing complex binding [GO:0044877]; purinergic nucleotide receptor activity [GO:0001614]; transmembrane signaling receptor activity [GO:0004888]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; channel activity [GO:0015267]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; protein-containing complex binding [GO:0044877]; purinergic nucleotide receptor activity [GO:0001614]; transmembrane signaling receptor activity [GO:0004888]; calcium ion transmembrane transport [GO:0070588]; muscle contraction [GO:0006936]; response to ATP [GO:0033198]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
O15550	reviewed	KDM6A_HUMAN	Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)	KDM6A UTX	Homo sapiens (Human)	1401	FUNCTION: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). {ECO:0000250|UniProtKB:O70546, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914}.	MISCELLANEOUS: Escapes X chromosome inactivation.	chromatin remodeling [GO:0006338]; regulation of gene expression [GO:0010468]	histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; chromatin remodeling [GO:0006338]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O15551	reviewed	CLD3_HUMAN	Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE-R 2) (CPE-receptor 2) (Rat ventral prostate.1 protein homolog) (hRVP1)	CLDN3 C7orf1 CPETR2	Homo sapiens (Human)	220	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250|UniProtKB:Q9Z0G9}.		actin cytoskeleton organization [GO:0030036]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; cell junction maintenance [GO:0034331]; epithelial cell morphogenesis [GO:0003382]; establishment of endothelial blood-brain barrier [GO:0014045]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of wound healing [GO:0061045]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; positive regulation of metallopeptidase activity [GO:1905050]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of wound healing [GO:0090303]; regulation of cell morphogenesis [GO:0022604]; regulation of membrane permeability [GO:0090559]; regulation of transepithelial transport [GO:0150111]; response to ethanol [GO:0045471]; response to Gram-positive bacterium [GO:0140459]; response to hypoxia [GO:0001666]	apical junction complex [GO:0043296]; apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; transmembrane signaling receptor activity [GO:0004888]	apical junction complex [GO:0043296]; apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; transmembrane signaling receptor activity [GO:0004888]; actin cytoskeleton organization [GO:0030036]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; cell junction maintenance [GO:0034331]; epithelial cell morphogenesis [GO:0003382]; establishment of endothelial blood-brain barrier [GO:0014045]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of wound healing [GO:0061045]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; positive regulation of metallopeptidase activity [GO:1905050]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of wound healing [GO:0090303]; regulation of cell morphogenesis [GO:0022604]; regulation of membrane permeability [GO:0090559]; regulation of transepithelial transport [GO:0150111]; response to ethanol [GO:0045471]; response to Gram-positive bacterium [GO:0140459]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Z0G9}. Cell membrane {ECO:0000250|UniProtKB:Q9Z0G9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Z0G9}.
O15552	reviewed	FFAR2_HUMAN	Free fatty acid receptor 2 (G-protein coupled receptor 43)	FFAR2 FFA2 GPCR43 GPR43	Homo sapiens (Human)	330	FUNCTION: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097). Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604). Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016). {ECO:0000269|PubMed:12496283, ECO:0000269|PubMed:12684041, ECO:0000269|PubMed:12711604, ECO:0000269|PubMed:18801738, ECO:0000269|PubMed:21037097, ECO:0000269|PubMed:23066016, ECO:0000269|PubMed:23589301}.		cell surface pattern recognition receptor signaling pathway [GO:0002752]; cellular response to fatty acid [GO:0071398]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; ligand-gated ion channel signaling pathway [GO:1990806]; lipid storage [GO:0019915]; mucosal immune response [GO:0002385]; negative regulation of insulin secretion [GO:0046676]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of acute inflammatory response to non-antigenic stimulus [GO:0002879]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-8 production [GO:0032757]; regulation of acute inflammatory response [GO:0002673]; regulation of peptide hormone secretion [GO:0090276]	cell projection [GO:0042995]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]	cell projection [GO:0042995]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; cellular response to fatty acid [GO:0071398]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; ligand-gated ion channel signaling pathway [GO:1990806]; lipid storage [GO:0019915]; mucosal immune response [GO:0002385]; negative regulation of insulin secretion [GO:0046676]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of acute inflammatory response to non-antigenic stimulus [GO:0002879]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-8 production [GO:0032757]; regulation of acute inflammatory response [GO:0002673]; regulation of peptide hormone secretion [GO:0090276]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18801738}; Multi-pass membrane protein {ECO:0000269|PubMed:18801738}.
O15553	reviewed	MEFV_HUMAN	Pyrin (Marenostrin)	MEFV MEF TRIM20	Homo sapiens (Human)	781	FUNCTION: Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923, PubMed:16037825, PubMed:27030597, PubMed:28835462, PubMed:16785446, PubMed:17431422, PubMed:26347139). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (PubMed:16785446, PubMed:17431422, PubMed:26347139). Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (PubMed:16037825, PubMed:27030597, PubMed:28835462). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). {ECO:0000250|UniProtKB:Q9JJ26, ECO:0000269|PubMed:10807793, ECO:0000269|PubMed:11468188, ECO:0000269|PubMed:16037825, ECO:0000269|PubMed:16785446, ECO:0000269|PubMed:17431422, ECO:0000269|PubMed:17964261, ECO:0000269|PubMed:18577712, ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:26347139, ECO:0000269|PubMed:27030597, ECO:0000269|PubMed:28835462}.		inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; protein ubiquitination [GO:0016567]; pyroptosis [GO:0070269]; pyroptosome complex assembly [GO:1904270]; regulation of gene expression [GO:0010468]; regulation of interleukin-1 beta production [GO:0032651]; response to type II interferon [GO:0034341]	autophagosome [GO:0005776]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726]	actin binding [GO:0003779]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	autophagosome [GO:0005776]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726]; actin binding [GO:0003779]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; protein ubiquitination [GO:0016567]; pyroptosis [GO:0070269]; pyroptosome complex assembly [GO:1904270]; regulation of gene expression [GO:0010468]; regulation of interleukin-1 beta production [GO:0032651]; response to type II interferon [GO:0034341]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11468188, ECO:0000269|PubMed:19109554}. Cell projection, ruffle {ECO:0000269|PubMed:11468188}. Cell projection, lamellipodium {ECO:0000269|PubMed:11468188}. Nucleus {ECO:0000269|PubMed:11115844}. Cytoplasm {ECO:0000269|PubMed:10666224, ECO:0000269|PubMed:11498534, ECO:0000269|PubMed:18577712, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:26347139}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:26347139}. Note=Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles (PubMed:11468188). In pre-apoptotic cells, colocalizes with PYCARD/ASC in large specks (inflammasomes) (PubMed:11468188). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC (PubMed:11468188). {ECO:0000269|PubMed:11468188}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:11115844}.
O15554	reviewed	KCNN4_HUMAN	Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos channel)	KCNN4 IK1 IKCA1 KCA4 SK4	Homo sapiens (Human)	427	FUNCTION: Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580). {ECO:0000269|PubMed:17157250, ECO:0000269|PubMed:18796614, ECO:0000269|PubMed:24591580, ECO:0000269|PubMed:26148990}.		calcium ion transport [GO:0006816]; cell volume homeostasis [GO:0006884]; defense response [GO:0006952]; establishment of localization in cell [GO:0051649]; immune system process [GO:0002376]; phospholipid translocation [GO:0045332]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell receptor signaling pathway [GO:0050862]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; saliva secretion [GO:0046541]; stabilization of membrane potential [GO:0030322]	cytosol [GO:0005829]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076]	calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; Intermediate conductance calcium-activated potassium channel activity [GO:0022894]; potassium channel activity [GO:0005267]; protein phosphatase binding [GO:0019903]; small conductance calcium-activated potassium channel activity [GO:0016286]	cytosol [GO:0005829]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076]; calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; Intermediate conductance calcium-activated potassium channel activity [GO:0022894]; potassium channel activity [GO:0005267]; protein phosphatase binding [GO:0019903]; small conductance calcium-activated potassium channel activity [GO:0016286]; calcium ion transport [GO:0006816]; cell volume homeostasis [GO:0006884]; defense response [GO:0006952]; establishment of localization in cell [GO:0051649]; immune system process [GO:0002376]; phospholipid translocation [GO:0045332]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell receptor signaling pathway [GO:0050862]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; saliva secretion [GO:0046541]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26148990}; Multi-pass membrane protein {ECO:0000255}.
O42043	reviewed	ENK18_HUMAN	Endogenous retrovirus group K member 18 Env polyprotein (Envelope polyprotein) (HERV-K(C1a) envelope protein) (HERV-K110 envelope protein) (HERV-K18 envelope protein) (HERV-K18 superantigen) (HERV-K_1q23.3 provirus ancestral Env polyprotein) (IDDMK1,2 22 envelope protein) (IDDMK1,2 22 superantigen) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERVK-18	Homo sapiens (Human)	560	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This envelope protein has superantigenic properties.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: Orthologs in P.troglodytes and G.gorilla.; MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.; MISCELLANEOUS: Autoantibodies reactive to this envelope are detectable in sera from healthy donors and individuals with autoimmune diseases.; MISCELLANEOUS: Intragenic, in the first intron of CD48 gene.		plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.; SUBCELLULAR LOCATION: [Endogenous retrovirus group K member 18 Env polyprotein]: Virion {ECO:0000250}.
O43143	reviewed	DHX15_HUMAN	ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43)	DHX15 DBP1 DDX15	Homo sapiens (Human)	795	FUNCTION: RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:19432882, PubMed:19103666, PubMed:32179686, PubMed:24990078, PubMed:24782566, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (PubMed:19103666). In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (PubMed:19103666). Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome (PubMed:24990078, PubMed:24782566, PubMed:34161762). Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) (PubMed:24990078, PubMed:24782566, PubMed:34161762). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses (PubMed:34161762). The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (PubMed:34161762). Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity). {ECO:0000250|UniProtKB:O35286, ECO:0000269|PubMed:19103666, ECO:0000269|PubMed:19432882, ECO:0000269|PubMed:24782566, ECO:0000269|PubMed:24990078, ECO:0000269|PubMed:32179686, ECO:0000269|PubMed:34161762}.		antiviral innate immune response [GO:0140374]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; response to alkaloid [GO:0043279]; response to toxic substance [GO:0009636]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; antiviral innate immune response [GO:0140374]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; response to alkaloid [GO:0043279]; response to toxic substance [GO:0009636]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12458796}. Nucleus, nucleolus {ECO:0000269|PubMed:12458796}.
O43147	reviewed	SGSM2_HUMAN	Small G protein signaling modulator 2 (RUN and TBC1 domain-containing protein 1)	SGSM2 KIAA0397 RUTBC1	Homo sapiens (Human)	1006	FUNCTION: Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560). {ECO:0000269|PubMed:21808068, ECO:0000269|PubMed:26620560}.		late endosome to Golgi transport [GO:0034499]; positive regulation of GTPase activity [GO:0043547]	cytoplasm [GO:0005737]; melanosome [GO:0042470]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; melanosome [GO:0042470]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; late endosome to Golgi transport [GO:0034499]; positive regulation of GTPase activity [GO:0043547]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26620560}. Melanosome {ECO:0000269|PubMed:26620560}. Note=Melanosomal localization is mediated by RAB9A. {ECO:0000269|PubMed:26620560}.
O43148	reviewed	MCES_HUMAN	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p)	RNMT KIAA0398	Homo sapiens (Human)	476	FUNCTION: Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}.		7-methylguanosine mRNA capping [GO:0006370]; cellular response to leukemia inhibitory factor [GO:1990830]	fibrillar center [GO:0001650]; mRNA cap binding complex [GO:0005845]; mRNA cap methyltransferase complex [GO:0031533]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]	mRNA (guanine-N7-)-methyltransferase activity [GO:0004482]; RNA binding [GO:0003723]	fibrillar center [GO:0001650]; mRNA cap binding complex [GO:0005845]; mRNA cap methyltransferase complex [GO:0031533]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; mRNA (guanine-N7-)-methyltransferase activity [GO:0004482]; RNA binding [GO:0003723]; 7-methylguanosine mRNA capping [GO:0006370]; cellular response to leukemia inhibitory factor [GO:1990830]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:15767670}.
O43149	reviewed	ZZEF1_HUMAN	Zinc finger ZZ-type and EF-hand domain-containing protein 1	ZZEF1 KIAA0399	Homo sapiens (Human)	2961	FUNCTION: Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors. {ECO:0000269|PubMed:33227311}.	MISCELLANEOUS: [Isoform 2]: Incomplete sequence. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to an intron retention. {ECO:0000305}.			calcium ion binding [GO:0005509]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]	calcium ion binding [GO:0005509]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]	
O43150	reviewed	ASAP2_HUMAN	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP)	ASAP2 DDEF2 KIAA0400	Homo sapiens (Human)	1006	FUNCTION: Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:10749932, ECO:0000269|PubMed:11304556}.			cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin and ARF6 in phagocytic cups.
O43151	reviewed	TET3_HUMAN	Methylcytosine dioxygenase TET3 (EC 1.14.11.80)	TET3 KIAA0401	Homo sapiens (Human)	1795	FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization (PubMed:31928709). Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes (PubMed:23217707). In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT (PubMed:23353889). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q8BG87, ECO:0000269|PubMed:23217707, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:31928709}.		5-methylcytosine catabolic process [GO:0006211]; DNA demethylation [GO:0080111]; epigenetic programing of male pronucleus [GO:0044727]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nucleus [GO:0005634]	methyl-CpG binding [GO:0008327]; methylcytosine dioxygenase activity [GO:0070579]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nucleus [GO:0005634]; methyl-CpG binding [GO:0008327]; methylcytosine dioxygenase activity [GO:0070579]; zinc ion binding [GO:0008270]; 5-methylcytosine catabolic process [GO:0006211]; DNA demethylation [GO:0080111]; epigenetic programing of male pronucleus [GO:0044727]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BG87}. Cytoplasm {ECO:0000250|UniProtKB:Q8BG87}. Chromosome {ECO:0000250|UniProtKB:Q8BG87}. Note=At the zygotic stage, localizes in the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages. Binds to the promoter of target genes, close to the transcription start site. {ECO:0000250|UniProtKB:Q8BG87}.
O43155	reviewed	FLRT2_HUMAN	Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2)	FLRT2 KIAA0405 UNQ232/PRO265	Homo sapiens (Human)	660	FUNCTION: Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. {ECO:0000250|UniProtKB:Q8BLU0}.		axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; cell adhesion involved in heart morphogenesis [GO:0061343]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; positive regulation of synapse assembly [GO:0051965]; regulation of neuron migration [GO:2001222]	cell-cell junction [GO:0005911]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]	chemorepellent activity [GO:0045499]; fibroblast growth factor receptor binding [GO:0005104]; protein-macromolecule adaptor activity [GO:0030674]	cell-cell junction [GO:0005911]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]; chemorepellent activity [GO:0045499]; fibroblast growth factor receptor binding [GO:0005104]; protein-macromolecule adaptor activity [GO:0030674]; axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; cell adhesion involved in heart morphogenesis [GO:0061343]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; positive regulation of synapse assembly [GO:0051965]; regulation of neuron migration [GO:2001222]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BLU0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8BLU0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BLU0}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q8BLU0}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q8BLU0}. Microsome membrane {ECO:0000250|UniProtKB:Q8BLU0}. Secreted {ECO:0000250|UniProtKB:Q8BLU0}. Synapse, synaptosome {ECO:0000250|UniProtKB:D3ZTV3}. Note=Proteolytic cleavage gives rise to a shedded ectodomain. {ECO:0000250|UniProtKB:Q8BLU0}.
O43156	reviewed	TTI1_HUMAN	TELO2-interacting protein 1 homolog (Protein SMG10)	TTI1 KIAA0406 SMG10	Homo sapiens (Human)	1089	FUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650}.		chromatin remodeling [GO:0006338]; positive regulation of DNA damage checkpoint [GO:2000003]; protein stabilization [GO:0050821]; regulation of TOR signaling [GO:0032006]	ASTRA complex [GO:0070209]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]; TTT complex [GO:0110078]		ASTRA complex [GO:0070209]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]; TTT complex [GO:0110078]; chromatin remodeling [GO:0006338]; positive regulation of DNA damage checkpoint [GO:2000003]; protein stabilization [GO:0050821]; regulation of TOR signaling [GO:0032006]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23263282}.
O43157	reviewed	PLXB1_HUMAN	Plexin-B1 (Semaphorin receptor SEP)	PLXNB1 KIAA0407 PLXN5 SEP	Homo sapiens (Human)	2135	FUNCTION: Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496). {ECO:0000250|UniProtKB:Q8CJH3, ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496, ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}.		cell migration [GO:0016477]; inhibitory synapse assembly [GO:1904862]; intracellular signal transduction [GO:0035556]; negative regulation of cell adhesion [GO:0007162]; negative regulation of osteoblast proliferation [GO:0033689]; neuron projection morphogenesis [GO:0048812]; ossification involved in bone maturation [GO:0043931]; positive regulation of axonogenesis [GO:0050772]; positive regulation of GTPase activity [GO:0043547]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [GO:1900220]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; semaphorin receptor activity [GO:0017154]; semaphorin receptor binding [GO:0030215]; transmembrane signaling receptor activity [GO:0004888]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]; GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; semaphorin receptor activity [GO:0017154]; semaphorin receptor binding [GO:0030215]; transmembrane signaling receptor activity [GO:0004888]; cell migration [GO:0016477]; inhibitory synapse assembly [GO:1904862]; intracellular signal transduction [GO:0035556]; negative regulation of cell adhesion [GO:0007162]; negative regulation of osteoblast proliferation [GO:0033689]; neuron projection morphogenesis [GO:0048812]; ossification involved in bone maturation [GO:0043931]; positive regulation of axonogenesis [GO:0050772]; positive regulation of GTPase activity [GO:0043547]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [GO:1900220]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12533544}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:10520995}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:10520995}.
O43159	reviewed	RRP8_HUMAN	Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin)	RRP8 KIAA0409 NML hucep-1	Homo sapiens (Human)	456	FUNCTION: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}.		cellular response to glucose starvation [GO:0042149]; energy homeostasis [GO:0097009]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; methylation [GO:0032259]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of histone deacetylation [GO:0031065]; rDNA heterochromatin formation [GO:0000183]; regulation of G1 to G0 transition [GO:1903450]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364]	chromatin silencing complex [GO:0005677]; cytosol [GO:0005829]; eNoSc complex [GO:0061773]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; rDNA heterochromatin [GO:0033553]	methylated histone binding [GO:0035064]; RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	chromatin silencing complex [GO:0005677]; cytosol [GO:0005829]; eNoSc complex [GO:0061773]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; rDNA heterochromatin [GO:0033553]; methylated histone binding [GO:0035064]; RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; cellular response to glucose starvation [GO:0042149]; energy homeostasis [GO:0097009]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; methylation [GO:0032259]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of histone deacetylation [GO:0031065]; rDNA heterochromatin formation [GO:0000183]; regulation of G1 to G0 transition [GO:1903450]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:18485871}. Note=Localizes at rDNA locus.
O43164	reviewed	PJA2_HUMAN	E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2)	PJA2 KIAA0438 RNF131	Homo sapiens (Human)	708	FUNCTION: Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}.		inflammatory response [GO:0006954]; innate immune response [GO:0045087]; long-term memory [GO:0007616]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of macrophage activation [GO:0043030]; regulation of protein kinase A signaling [GO:0010738]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; intermediate filament cytoskeleton [GO:0045111]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	metal ion binding [GO:0046872]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; intermediate filament cytoskeleton [GO:0045111]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; metal ion binding [GO:0046872]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; long-term memory [GO:0007616]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of macrophage activation [GO:0043030]; regulation of protein kinase A signaling [GO:0010738]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21423175}; Peripheral membrane protein {ECO:0000269|PubMed:21423175}. Golgi apparatus membrane {ECO:0000269|PubMed:21423175}; Peripheral membrane protein {ECO:0000269|PubMed:21423175}. Synapse {ECO:0000250|UniProtKB:Q63364}. Postsynaptic density {ECO:0000250|UniProtKB:Q63364}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:33934390}. Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus (PubMed:21423175). Expressed in the postsynaptic density region of synapses (By similarity). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane (PubMed:21423175). {ECO:0000250|UniProtKB:Q63364, ECO:0000269|PubMed:21423175}.
O43166	reviewed	SI1L1_HUMAN	Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)	SIPA1L1 E6TP1 KIAA0440	Homo sapiens (Human)	1804	FUNCTION: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.		actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; ephrin receptor signaling pathway [GO:0048013]; regulation of axonogenesis [GO:0050770]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of synaptic plasticity [GO:0048167]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	ephrin receptor binding [GO:0046875]; GTPase activator activity [GO:0005096]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ephrin receptor binding [GO:0046875]; GTPase activator activity [GO:0005096]; actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; ephrin receptor signaling pathway [GO:0048013]; regulation of axonogenesis [GO:0050770]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of synaptic plasticity [GO:0048167]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity). {ECO:0000250}.
O43167	reviewed	ZBT24_HUMAN	Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450)	ZBTB24 KIAA0441 ZNF450	Homo sapiens (Human)	697	FUNCTION: May be involved in BMP2-induced transcription. {ECO:0000250}.		hematopoietic progenitor cell differentiation [GO:0002244]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O43169	reviewed	CYB5B_HUMAN	Cytochrome b5 type B (Cytochrome b5 outer mitochondrial membrane isoform)	CYB5B CYB5M OMB5	Homo sapiens (Human)	150	FUNCTION: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. {ECO:0000250}.		nitric oxide biosynthetic process [GO:0006809]; response to oxidative stress [GO:0006979]; xenobiotic metabolic process [GO:0006805]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nitric-oxide synthase complex [GO:1903958]	enzyme activator activity [GO:0008047]; heme binding [GO:0020037]; metal ion binding [GO:0046872]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nitric-oxide synthase complex [GO:1903958]; enzyme activator activity [GO:0008047]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; nitric oxide biosynthetic process [GO:0006809]; response to oxidative stress [GO:0006979]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P04166}.
O43172	reviewed	PRP4_HUMAN	U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4)	PRPF4 PRP4	Homo sapiens (Human)	522	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:28781166}.		mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	Cajal body [GO:0015030]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; spliceosomal snRNP complex [GO:0097525]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]	Cajal body [GO:0015030]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; spliceosomal snRNP complex [GO:0097525]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]; mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9257651, ECO:0000269|PubMed:9328476, ECO:0000269|PubMed:9404889}. Nucleus speckle {ECO:0000305}.
O43173	reviewed	SIA8C_HUMAN	Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase (EC 2.4.99.-) (Alpha-2,8-sialyltransferase 8C) (Alpha-2,8-sialyltransferase III) (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3) (Sialyltransferase 8C) (SIAT8-C) (Sialyltransferase St8Sia III) (ST8SiaIII)	ST8SIA3 SIAT8C	Homo sapiens (Human)	380	FUNCTION: Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid. {ECO:0000269|PubMed:10766765, ECO:0000269|PubMed:26192331, ECO:0000269|PubMed:9826427}.		ganglioside biosynthetic process [GO:0001574]; glycoprotein metabolic process [GO:0009100]; glycosphingolipid biosynthetic process [GO:0006688]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; protein sialylation [GO:1990743]	Golgi membrane [GO:0000139]	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; identical protein binding [GO:0042802]; sialic acid binding [GO:0033691]; sialyltransferase activity [GO:0008373]	Golgi membrane [GO:0000139]; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; identical protein binding [GO:0042802]; sialic acid binding [GO:0033691]; sialyltransferase activity [GO:0008373]; ganglioside biosynthetic process [GO:0001574]; glycoprotein metabolic process [GO:0009100]; glycosphingolipid biosynthetic process [GO:0006688]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; protein sialylation [GO:1990743]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
O43174	reviewed	CP26A_HUMAN	Cytochrome P450 26A1 (CYP26A1) (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome)	CYP26A1 CYP26 P450RAI1	Homo sapiens (Human)	497	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed:22020119, PubMed:9228017, PubMed:9716180). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (PubMed:22020119, PubMed:9228017, PubMed:9716180). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA (By similarity) (PubMed:9228017). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed:26937021). {ECO:0000250|UniProtKB:O55127, ECO:0000269|PubMed:22020119, ECO:0000269|PubMed:26937021, ECO:0000269|PubMed:9228017, ECO:0000269|PubMed:9716180, ECO:0000305|PubMed:22020119, ECO:0000305|PubMed:9228017}.		kidney development [GO:0001822]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinoic acid catabolic process [GO:0034653]; retinoic acid metabolic process [GO:0042573]; sterol metabolic process [GO:0016125]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]	all-trans retinoic acid 18-hydroxylase activity [GO:0062183]; all-trans retinoic acid 4-hydrolase activity [GO:0062182]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; oxygen binding [GO:0019825]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]	endoplasmic reticulum membrane [GO:0005789]; all-trans retinoic acid 18-hydroxylase activity [GO:0062183]; all-trans retinoic acid 4-hydrolase activity [GO:0062182]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; oxygen binding [GO:0019825]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]; kidney development [GO:0001822]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinoic acid catabolic process [GO:0034653]; retinoic acid metabolic process [GO:0042573]; sterol metabolic process [GO:0016125]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:9716180}; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:9716180}; Peripheral membrane protein.
O43175	reviewed	SERA_HUMAN	D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37)	PHGDH PGDH3	Homo sapiens (Human)	533	FUNCTION: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}.		brain development [GO:0007420]; G1 to G0 transition [GO:0070314]; gamma-aminobutyric acid metabolic process [GO:0009448]; glial cell development [GO:0021782]; glutamine metabolic process [GO:0006541]; glycine metabolic process [GO:0006544]; L-serine biosynthetic process [GO:0006564]; neural tube development [GO:0021915]; neuron projection development [GO:0031175]; regulation of gene expression [GO:0010468]; spinal cord development [GO:0021510]; taurine metabolic process [GO:0019530]; threonine metabolic process [GO:0006566]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	electron transfer activity [GO:0009055]; L-malate dehydrogenase activity [GO:0030060]; NAD binding [GO:0051287]; phosphoglycerate dehydrogenase activity [GO:0004617]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; electron transfer activity [GO:0009055]; L-malate dehydrogenase activity [GO:0030060]; NAD binding [GO:0051287]; phosphoglycerate dehydrogenase activity [GO:0004617]; brain development [GO:0007420]; G1 to G0 transition [GO:0070314]; gamma-aminobutyric acid metabolic process [GO:0009448]; glial cell development [GO:0021782]; glutamine metabolic process [GO:0006541]; glycine metabolic process [GO:0006544]; L-serine biosynthetic process [GO:0006564]; neural tube development [GO:0021915]; neuron projection development [GO:0031175]; regulation of gene expression [GO:0010468]; spinal cord development [GO:0021510]; taurine metabolic process [GO:0019530]; threonine metabolic process [GO:0006566]	
O43181	reviewed	NDUS4_HUMAN	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (Complex I-AQDQ) (CI-AQDQ) (NADH-ubiquinone oxidoreductase 18 kDa subunit)	NDUFS4	Homo sapiens (Human)	175	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:11181577, ECO:0000269|PubMed:12611891, ECO:0000269|PubMed:9463323}.		aerobic respiration [GO:0009060]; brain development [GO:0007420]; cellular respiration [GO:0045333]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; positive regulation of fibroblast proliferation [GO:0048146]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]; regulation of protein phosphorylation [GO:0001932]; response to cAMP [GO:0051591]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; brain development [GO:0007420]; cellular respiration [GO:0045333]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; positive regulation of fibroblast proliferation [GO:0048146]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]; regulation of protein phosphorylation [GO:0001932]; response to cAMP [GO:0051591]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11181577, ECO:0000269|PubMed:12611891, ECO:0000269|PubMed:31206022}; Peripheral membrane protein {ECO:0000269|PubMed:12611891}; Matrix side {ECO:0000269|PubMed:12611891}. Note=The interaction with BCAP31 mediates mitochondria localization. {ECO:0000269|PubMed:31206022}.
O43182	reviewed	RHG06_HUMAN	Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1)	ARHGAP6 RHOGAP6	Homo sapiens (Human)	974	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}.	MISCELLANEOUS: ARHGAP6 gene undergoes X inactivation.	actin filament polymerization [GO:0030041]; activation of phospholipase C activity [GO:0007202]; focal adhesion assembly [GO:0048041]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of phospholipase activity [GO:0010518]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GTPase activator activity [GO:0005096]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; SH3 domain binding [GO:0017124]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; SH3 domain binding [GO:0017124]; actin filament polymerization [GO:0030041]; activation of phospholipase C activity [GO:0007202]; focal adhesion assembly [GO:0048041]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of phospholipase activity [GO:0010518]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10699171}.
O43184	reviewed	ADA12_HUMAN	Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha)	ADAM12 MLTN UNQ346/PRO545	Homo sapiens (Human)	909	FUNCTION: Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; myoblast fusion [GO:0007520]; positive regulation of angiogenesis [GO:0045766]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; SH3 domain binding [GO:0017124]	extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; SH3 domain binding [GO:0017124]; cell adhesion [GO:0007155]; myoblast fusion [GO:0007520]; positive regulation of angiogenesis [GO:0045766]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000305}.
O43186	reviewed	CRX_HUMAN	Cone-rod homeobox protein	CRX CORD2	Homo sapiens (Human)	299	FUNCTION: Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. {ECO:0000269|PubMed:10625658}.		animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; leucine zipper domain binding [GO:0043522]; nuclear receptor binding [GO:0016922]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; leucine zipper domain binding [GO:0043522]; nuclear receptor binding [GO:0016922]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
O43187	reviewed	IRAK2_HUMAN	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)	IRAK2	Homo sapiens (Human)	625	FUNCTION: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. {ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:9374458}.		canonical NF-kappaB signal transduction [GO:0007249]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein phosphorylation [GO:0006468]; regulation of cytokine-mediated signaling pathway [GO:0001959]; response to interleukin-1 [GO:0070555]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein phosphorylation [GO:0006468]; regulation of cytokine-mediated signaling pathway [GO:0001959]; response to interleukin-1 [GO:0070555]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]	
O43189	reviewed	PHF1_HUMAN	PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1)	PHF1 PCL1	Homo sapiens (Human)	567	FUNCTION: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464, PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. {ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:18385154, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23150668, ECO:0000269|PubMed:23273982}.		chromatin organization [GO:0006325]; DNA repair-dependent chromatin remodeling [GO:0140861]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; transcription corepressor binding [GO:0001222]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; transcription corepressor binding [GO:0001222]; chromatin organization [GO:0006325]; DNA repair-dependent chromatin remodeling [GO:0140861]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes specifically to the promoters of numerous target genes. Localizes to double-strand breaks (DSBs) sites following DNA damage. Co-localizes with NEK6 in the centrosome.
O43193	reviewed	MTLR_HUMAN	Motilin receptor (G-protein coupled receptor 38)	MLNR GPR38 MTLR MTLR1	Homo sapiens (Human)	412	FUNCTION: Receptor for motilin. {ECO:0000269|PubMed:11322507}.		G protein-coupled receptor signaling pathway [GO:0007186]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; hormone binding [GO:0042562]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; hormone binding [GO:0042562]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O43194	reviewed	GPR39_HUMAN	G-protein coupled receptor 39	GPR39	Homo sapiens (Human)	453	FUNCTION: Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity). {ECO:0000250}.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; metal ion binding [GO:0046872]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; metal ion binding [GO:0046872]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O43196	reviewed	MSH5_HUMAN	MutS protein homolog 5 (hMSH5)	MSH5	Homo sapiens (Human)	834	FUNCTION: Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity). {ECO:0000250}.		chiasma assembly [GO:0051026]; mismatch repair [GO:0006298]	nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; double-stranded DNA binding [GO:0003690]; mismatched DNA binding [GO:0030983]	nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; double-stranded DNA binding [GO:0003690]; mismatched DNA binding [GO:0030983]; chiasma assembly [GO:0051026]; mismatch repair [GO:0006298]	
O43236	reviewed	SEPT4_HUMAN	Septin-4 (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Peanut-like protein 2)	SEPTIN4 C17orf47 PNUTL2 SEP4 SEPT4 hucep-7	Homo sapiens (Human)	478	FUNCTION: Filament-forming cytoskeletal GTPase (Probable). Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (By similarity). May also play a role in the regulation of cell fate in the intestine (By similarity). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (By similarity). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (By similarity). Plays an important role in male fertility and sperm motility (By similarity). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (By similarity). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (By similarity). {ECO:0000250|UniProtKB:P28661, ECO:0000305}.; FUNCTION: [Isoform ARTS]: Required for the induction of cell death mediated by TGF-beta and possibly by other apoptotic stimuli (PubMed:11146656, PubMed:15837787). Induces apoptosis through binding and inhibition of XIAP resulting in significant reduction in XIAP levels, leading to caspase activation and cell death (PubMed:15029247). Mediates the interaction between BCL2 and XIAP, thereby positively regulating the ubiquitination and degradation of BCL2 and promoting apoptosis (PubMed:29020630). {ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:15029247, ECO:0000269|PubMed:15837787, ECO:0000269|PubMed:29020630}.	MISCELLANEOUS: Colocalizes with alpha-synuclein in Lewy bodies in the substantia nigra pars compacta of Parkinson disease patients (PubMed:17296554). Shows reduced expression in dopaminergic nerve terminals of the striatum in sporadic Parkinson disease (PubMed:17296554). {ECO:0000269|PubMed:17296554}.; MISCELLANEOUS: [Isoform ARTS]: May be defective in GTP-binding. {ECO:0000305}.	apoptotic process [GO:0006915]; cytoskeleton-dependent cytokinesis [GO:0061640]; flagellated sperm motility [GO:0030317]; hematopoietic stem cell homeostasis [GO:0061484]; neuron migration [GO:0001764]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of exocytosis [GO:0017157]; spermatid differentiation [GO:0048515]	axon [GO:0030424]; cell division site [GO:0032153]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule cytoskeleton [GO:0015630]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; synaptic vesicle [GO:0008021]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198]	axon [GO:0030424]; cell division site [GO:0032153]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule cytoskeleton [GO:0015630]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; synaptic vesicle [GO:0008021]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198]; apoptotic process [GO:0006915]; cytoskeleton-dependent cytokinesis [GO:0061640]; flagellated sperm motility [GO:0030317]; hematopoietic stem cell homeostasis [GO:0061484]; neuron migration [GO:0001764]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of exocytosis [GO:0017157]; spermatid differentiation [GO:0048515]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P28661}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:25588830}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:15116257}. Cell projection, axon {ECO:0000250|UniProtKB:P28661}. Cell projection, dendrite {ECO:0000250|UniProtKB:P28661}. Perikaryon {ECO:0000250|UniProtKB:P28661}. Synapse {ECO:0000269|PubMed:17296554}. Note=In platelets, found in areas surrounding alpha-granules (PubMed:15116257). Found in the sperm annulus, a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum (PubMed:25588830). Expressed and colocalized with SLC6A3 and SNCA in axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:P28661, ECO:0000269|PubMed:15116257, ECO:0000269|PubMed:25588830}.; SUBCELLULAR LOCATION: [Isoform ARTS]: Mitochondrion {ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:15029247, ECO:0000269|PubMed:21695558}. Nucleus {ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:15029247}. Note=While predominantly localized in the mitochondria under resting conditions, translocates into the nucleus after TGF-beta treatment and apoptosis induction. {ECO:0000269|PubMed:11146656}.
O43237	reviewed	DC1L2_HUMAN	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55)	DYNC1LI2 DNCLI2 LIC2	Homo sapiens (Human)	492	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. {ECO:0000305|PubMed:36071160}.		cellular response to nerve growth factor stimulus [GO:1990090]; centrosome localization [GO:0051642]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based movement [GO:0007018]	centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynein complex [GO:0030286]; kinetochore [GO:0000776]; late endosome [GO:0005770]; membrane [GO:0016020]; microtubule [GO:0005874]	ATP binding [GO:0005524]; dynein heavy chain binding [GO:0045504]; identical protein binding [GO:0042802]	centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynein complex [GO:0030286]; kinetochore [GO:0000776]; late endosome [GO:0005770]; membrane [GO:0016020]; microtubule [GO:0005874]; ATP binding [GO:0005524]; dynein heavy chain binding [GO:0045504]; identical protein binding [GO:0042802]; cellular response to nerve growth factor stimulus [GO:1990090]; centrosome localization [GO:0051642]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305|PubMed:36071160}.
O43240	reviewed	KLK10_HUMAN	Kallikrein-10 (EC 3.4.21.-) (Normal epithelial cell-specific 1) (Protease serine-like 1)	KLK10 NES1 PRSSL1	Homo sapiens (Human)	276	FUNCTION: Has a tumor-suppressor role for NES1 in breast and prostate cancer.		cell cycle [GO:0007049]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; secretory granule [GO:0030141]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular region [GO:0005576]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; cell cycle [GO:0007049]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O43242	reviewed	PSMD3_HUMAN	26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)	PSMD3	Homo sapiens (Human)	534	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]	enzyme regulator activity [GO:0030234]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]; enzyme regulator activity [GO:0030234]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent protein catabolic process [GO:0006511]	
O43248	reviewed	HXC11_HUMAN	Homeobox protein Hox-C11 (Homeobox protein Hox-3H)	HOXC11 HOX3H	Homo sapiens (Human)	304	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.		anatomical structure development [GO:0048856]; anterior/posterior pattern specification [GO:0009952]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal joint morphogenesis [GO:0060272]; endoderm development [GO:0007492]; metanephros development [GO:0001656]; organ induction [GO:0001759]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure development [GO:0048856]; anterior/posterior pattern specification [GO:0009952]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal joint morphogenesis [GO:0060272]; endoderm development [GO:0007492]; metanephros development [GO:0001656]; organ induction [GO:0001759]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
O43251	reviewed	RFOX2_HUMAN	RNA binding protein fox-1 homolog 2 (Fox-1 homolog B) (Hexaribonucleotide-binding protein 2) (RNA-binding motif protein 9) (RNA-binding protein 9) (Repressor of tamoxifen transcriptional activity)	RBFOX2 FOX2 HRNBP2 RBM9 RTA	Homo sapiens (Human)	390	FUNCTION: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. {ECO:0000250, ECO:0000269|PubMed:11875103}.		intracellular estrogen receptor signaling pathway [GO:0030520]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of cell population proliferation [GO:0042127]; RNA metabolic process [GO:0016070]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; intracellular estrogen receptor signaling pathway [GO:0030520]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of cell population proliferation [GO:0042127]; RNA metabolic process [GO:0016070]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}.
O43252	reviewed	PAPS1_HUMAN	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]	PAPSS1 ATPSK1 PAPSS	Homo sapiens (Human)	624	FUNCTION: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). {ECO:0000269|PubMed:14747722, ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242, ECO:0000269|PubMed:9668121}.		3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; phosphorylation [GO:0016310]; skeletal system development [GO:0001501]; sulfate assimilation [GO:0000103]	cytosol [GO:0005829]	adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; sulfate adenylyltransferase (ATP) activity [GO:0004781]	cytosol [GO:0005829]; adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; sulfate adenylyltransferase (ATP) activity [GO:0004781]; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; phosphorylation [GO:0016310]; skeletal system development [GO:0001501]; sulfate assimilation [GO:0000103]	
O43255	reviewed	SIAH2_HUMAN	E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2)	SIAH2	Homo sapiens (Human)	324	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:9334332, PubMed:11483518, PubMed:19224863). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:9334332, PubMed:11483518, PubMed:19224863). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:9334332, PubMed:11483518, PubMed:19224863). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:9334332, PubMed:11483518, PubMed:19224863). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (PubMed:22878263). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:9334332, PubMed:11483518, PubMed:19224863, PubMed:22878263). Has some overlapping function with SIAH1 (PubMed:9334332, PubMed:11483518, PubMed:19224863). Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (PubMed:12411493). Promotes monoubiquitination of SNCA (PubMed:19224863). Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (PubMed:26392558). Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1. {ECO:0000250|UniProtKB:Q06986, ECO:0000269|PubMed:11483518, ECO:0000269|PubMed:12411493, ECO:0000269|PubMed:19224863, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:26392558, ECO:0000269|PubMed:28546513, ECO:0000269|PubMed:9334332}.		amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell cycle [GO:0007049]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; regulation of protein ubiquitination [GO:0031396]; rhythmic process [GO:0048511]; small GTPase mediated signal transduction [GO:0007264]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]	transcription corepressor activity [GO:0003714]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; transcription corepressor activity [GO:0003714]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell cycle [GO:0007049]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; regulation of protein ubiquitination [GO:0031396]; rhythmic process [GO:0048511]; small GTPase mediated signal transduction [GO:0007264]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19224863, ECO:0000269|PubMed:22878263}. Nucleus {ECO:0000269|PubMed:22878263}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000269|PubMed:22878263}.
O43257	reviewed	ZNHI1_HUMAN	Zinc finger HIT domain-containing protein 1 (Cyclin-G1-binding protein 1) (Zinc finger protein subfamily 4A member 1) (p18 Hamlet)	ZNHIT1 CGBP1 ZNFN4A1	Homo sapiens (Human)	154	FUNCTION: Plays a role in chromatin remodeling by promoting the incorporation of histone variant H2AZ1/H2A.Z into the genome to regulate gene expression (PubMed:20473270, PubMed:35175558). Promotes SRCAP complex-mediated deposition of histone variant H2AZ1 to lymphoid fate regulator genes, enhancing lymphoid lineage commitment (By similarity). Recruited to the promoter of the transcriptional activator MYOG at the early stages of muscle differentiation where it mediates binding of histone H2AZ1 to chromatin and induces muscle-specific gene expression (PubMed:20473270). Maintains hematopoietic stem cell (HSC) quiescence by determining the chromatin accessibility at distal enhancers of HSC quiescence genes such as PTEN, FSTL1 and KLF4, enhancing deposition of H2AZ1 to promote their sustained transcription and restricting PI3K-AKT signaling inhibition (By similarity). Plays a role in intestinal stem cell maintenance by promoting H2AZ1 deposition at the transcription start sites of genes involved in intestinal stem cell fate determination including LGR5, TGFB1 and TGFBR2, thereby contributing to gene transcription (By similarity). Promotes phosphorylation of the H2AZ1 chaperone VPS72/YL1 which enhances the interaction between HZAZ1 and VPS72 (By similarity). Regulates the entry of male germ cells into meiosis by controlling histone H2AZ1 deposition which facilitates the expression of meiotic genes such as MEIOSIN, leading to the initiation of meiosis (By similarity). Required for postnatal heart function through its role in maintenance of cardiac Ca(2+) homeostasis by modulating the expression of Ca(2+)-regulating proteins CASQ1 and ATP2A2/SERCA2A via deposition of histone H2AZ1 at their promoters (By similarity). During embryonic heart development, required for mitochondrial maturation and oxidative metabolism by functioning through H2AZ1 deposition to activate transcription of metabolic genes and is also required to maintain the stability of the respiratory complex (By similarity). In neural cells, increases deposition of the H2AZ1 histone variant and promotes neurite growth (PubMed:35175558). Plays a role in TP53/p53-mediated apoptosis induction by stimulating the transcriptional activation of several proapoptotic p53 target genes such as PMAIP1/NOXA and BBC3/PUMA (PubMed:17380123). Mediates cell cycle arrest induced in response to gamma-irradiation by enhancing recruitment of TP53/p53 to the promoter of the cell cycle inhibitor CDKN1A, leading to its transcriptional activation (PubMed:17700068). Recruited to the promoter of cyclin-dependent kinase CDK6 and inhibits its transcription, possibly by decreasing the acetylation level of histone H4, leading to cell cycle arrest at the G1 phase (By similarity). Plays a role in lens fiber cell differentiation by regulating the expression of cell cycle regulator CDKN1A/p21Cip1 (By similarity). Binds to transcriptional repressor NR1D2 and relieves it of its inhibitory effect on the transcription of apolipoprotein APOC3 without affecting its DNA-binding activity (PubMed:17892483). {ECO:0000250|UniProtKB:Q8R331, ECO:0000269|PubMed:17380123, ECO:0000269|PubMed:17700068, ECO:0000269|PubMed:17892483, ECO:0000269|PubMed:20473270, ECO:0000269|PubMed:35175558}.		calcium ion homeostasis [GO:0055074]; chromatin remodeling [GO:0006338]; heart process [GO:0003015]; intestinal stem cell homeostasis [GO:0036335]; muscle cell differentiation [GO:0042692]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of lymphoid progenitor cell differentiation [GO:1905458]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA-templated transcription [GO:0006355]	nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]	histone binding [GO:0042393]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]	nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; calcium ion homeostasis [GO:0055074]; chromatin remodeling [GO:0006338]; heart process [GO:0003015]; intestinal stem cell homeostasis [GO:0036335]; muscle cell differentiation [GO:0042692]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of lymphoid progenitor cell differentiation [GO:1905458]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17892483}.
O43264	reviewed	ZW10_HUMAN	Centromere/kinetochore protein zw10 homolog	ZW10	Homo sapiens (Human)	779	FUNCTION: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000305}.	MISCELLANEOUS: Overexpression as well as silencing of ZW10 disrupts the morphology of the ER-Golgi intermediate compartment as well as the Golgi apparatus and slows down ER-Golgi transport.	cell division [GO:0051301]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; meiotic cell cycle [GO:0051321]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of exit from mitosis [GO:0007096]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleus [GO:0005634]; RZZ complex [GO:1990423]; spindle pole [GO:0000922]	centromeric DNA binding [GO:0019237]	cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleus [GO:0005634]; RZZ complex [GO:1990423]; spindle pole [GO:0000922]; centromeric DNA binding [GO:0019237]; cell division [GO:0051301]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; meiotic cell cycle [GO:0051321]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of exit from mitosis [GO:0007096]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15029241}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15029241}; Peripheral membrane protein {ECO:0000269|PubMed:15029241}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11590237}. Lipid droplet {ECO:0000269|PubMed:30970241}. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm (PubMed:15029241). In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone (PubMed:11590237). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241}.
O43272	reviewed	PROD_HUMAN	Proline dehydrogenase 1, mitochondrial (EC 1.5.5.2) (Proline oxidase) (Proline oxidase 2) (p53-induced gene 6 protein)	PRODH PIG6 POX2 PRODH2	Homo sapiens (Human)	600	FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate. {ECO:0000269|PubMed:15662599}.		4-hydroxyproline catabolic process [GO:0019470]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; proline catabolic process [GO:0006562]; proline catabolic process to glutamate [GO:0010133]; proline metabolic process [GO:0006560]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	FAD binding [GO:0071949]; proline dehydrogenase activity [GO:0004657]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; FAD binding [GO:0071949]; proline dehydrogenase activity [GO:0004657]; 4-hydroxyproline catabolic process [GO:0019470]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; proline catabolic process [GO:0006562]; proline catabolic process to glutamate [GO:0010133]; proline metabolic process [GO:0006560]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376]	SUBCELLULAR LOCATION: Mitochondrion matrix.
O43278	reviewed	SPIT1_HUMAN	Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1)	SPINT1 HAI1 UNQ223/PRO256	Homo sapiens (Human)	529	FUNCTION: Inhibitor of HGFAC (PubMed:9045658). Inhibits serine protease activity of ST14/matriptase in vitro (PubMed:28710277). Inhibits serine protease activity of TMPRSS13, via the BPTI/Kunitz inhibitor 1 domain (PubMed:20977675). {ECO:0000269|PubMed:20977675, ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:9045658}.		branching involved in labyrinthine layer morphogenesis [GO:0060670]; cellular response to BMP stimulus [GO:0071773]; epidermis development [GO:0008544]; epithelium development [GO:0060429]; extracellular matrix organization [GO:0030198]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural tube closure [GO:0001843]; placenta blood vessel development [GO:0060674]; positive regulation of glial cell differentiation [GO:0045687]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]	serine-type endopeptidase inhibitor activity [GO:0004867]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; serine-type endopeptidase inhibitor activity [GO:0004867]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cellular response to BMP stimulus [GO:0071773]; epidermis development [GO:0008544]; epithelium development [GO:0060429]; extracellular matrix organization [GO:0030198]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural tube closure [GO:0001843]; placenta blood vessel development [GO:0060674]; positive regulation of glial cell differentiation [GO:0045687]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9045658}. Cytoplasm {ECO:0000269|PubMed:28710277}. Cell membrane {ECO:0000269|PubMed:28710277}.
O43280	reviewed	TREA_HUMAN	Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)	TREH TREA	Homo sapiens (Human)	583	FUNCTION: Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose. {ECO:0000269|PubMed:8773341, ECO:0000269|PubMed:9427547}.		animal organ morphogenesis [GO:0009887]; trehalose catabolic process [GO:0005993]; trehalose metabolic process [GO:0005991]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	alpha,alpha-trehalase activity [GO:0004555]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; alpha,alpha-trehalase activity [GO:0004555]; animal organ morphogenesis [GO:0009887]; trehalose catabolic process [GO:0005993]; trehalose metabolic process [GO:0005991]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P19813}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19813}.
O43281	reviewed	EFS_HUMAN	Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)	EFS CASS3	Homo sapiens (Human)	561	FUNCTION: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; cell migration [GO:0016477]; intracellular signal transduction [GO:0035556]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]	protein domain specific binding [GO:0019904]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; protein domain specific binding [GO:0019904]; SH3 domain binding [GO:0017124]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; intracellular signal transduction [GO:0035556]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	
O43283	reviewed	M3K13_HUMAN	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK)	MAP3K13 LZK	Homo sapiens (Human)	966	FUNCTION: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	JNK cascade [GO:0007254]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of axon extension [GO:0045773]; positive regulation of branching morphogenesis of a nerve [GO:1905492]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron maturation [GO:0014042]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; stress-activated MAPK cascade [GO:0051403]	cytoplasm [GO:0005737]; membrane [GO:0016020]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; IkappaB kinase complex binding [GO:0106137]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; membrane [GO:0016020]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; IkappaB kinase complex binding [GO:0106137]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; JNK cascade [GO:0007254]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of axon extension [GO:0045773]; positive regulation of branching morphogenesis of a nerve [GO:1905492]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron maturation [GO:0014042]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; stress-activated MAPK cascade [GO:0051403]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9353328}. Membrane {ECO:0000269|PubMed:9353328}; Peripheral membrane protein {ECO:0000269|PubMed:9353328}.
O43286	reviewed	B4GT5_HUMAN	Beta-1,4-galactosyltransferase 5 (Beta-1,4-GalTase 5) (Beta4Gal-T5) (b4Gal-T5) (EC 2.4.1.-) (Beta-1,4-GalT II) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5)	B4GALT5	Homo sapiens (Human)	388	FUNCTION: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:24498430). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity). {ECO:0000250|UniProtKB:Q9JMK0, ECO:0000269|PubMed:24498430}.		carbohydrate metabolic process [GO:0005975]; central nervous system myelination [GO:0022010]; central nervous system neuron axonogenesis [GO:0021955]; ganglioside biosynthetic process via lactosylceramide [GO:0010706]; glycoprotein biosynthetic process [GO:0009101]; glycosylation [GO:0070085]; neuron maturation [GO:0042551]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; positive regulation of embryonic development [GO:0040019]; protein glycosylation [GO:0006486]; regulation of protein stability [GO:0031647]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489]; carbohydrate metabolic process [GO:0005975]; central nervous system myelination [GO:0022010]; central nervous system neuron axonogenesis [GO:0021955]; ganglioside biosynthetic process via lactosylceramide [GO:0010706]; glycoprotein biosynthetic process [GO:0009101]; glycosylation [GO:0070085]; neuron maturation [GO:0042551]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; positive regulation of embryonic development [GO:0040019]; protein glycosylation [GO:0006486]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15291}; Single-pass type II membrane protein. Golgi apparatus {ECO:0000250|UniProtKB:A0A1S6M251}. Note=Trans cisternae of Golgi stack. {ECO:0000250|UniProtKB:P15291}.
O43290	reviewed	SNUT1_HUMAN	U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1)	SART1	Homo sapiens (Human)	800	FUNCTION: Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}.		maturation of 5S rRNA [GO:0000481]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of cytotoxic T cell differentiation [GO:0045585]; spliceosomal snRNP assembly [GO:0000387]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	RNA binding [GO:0003723]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; RNA binding [GO:0003723]; maturation of 5S rRNA [GO:0000481]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of cytotoxic T cell differentiation [GO:0045585]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:9449708}. Note=Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells.
O43291	reviewed	SPIT2_HUMAN	Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin)	SPINT2 HAI2 KOP	Homo sapiens (Human)	252	FUNCTION: Inhibitor of HGFAC (PubMed:9346890). Also inhibits plasmin, and plasma and tissue kallikrein (PubMed:9115294). Inhibits serine protease activity of TMPRSS13 (PubMed:20977675, PubMed:28710277). Inhibits serine protease activity of ST14/matriptase in vitro (PubMed:28710277). {ECO:0000269|PubMed:20977675, ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:9115294, ECO:0000269|PubMed:9346890}.		basement membrane organization [GO:0071711]; cellular response to BMP stimulus [GO:0071773]; epithelial cell morphogenesis involved in placental branching [GO:0060672]; establishment or maintenance of cell polarity [GO:0007163]; negative regulation of cell motility [GO:2000146]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural tube closure [GO:0001843]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; basement membrane organization [GO:0071711]; cellular response to BMP stimulus [GO:0071773]; epithelial cell morphogenesis involved in placental branching [GO:0060672]; establishment or maintenance of cell polarity [GO:0007163]; negative regulation of cell motility [GO:2000146]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural tube closure [GO:0001843]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:34562451}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:28710277}.
O43292	reviewed	GPAA1_HUMAN	Glycosylphosphatidylinositol anchor attachment 1 protein (GPI anchor attachment protein 1) (GAA1 protein homolog) (hGAA1)	GPAA1 GAA1	Homo sapiens (Human)	621	FUNCTION: Component of the GPI transamidase complex, necessary for transfer of GPI to proteins (PubMed:34576938). Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. {ECO:0000269|PubMed:29100095, ECO:0000269|PubMed:34576938, ECO:0000269|PubMed:9468317}.		attachment of GPI anchor to protein [GO:0016255]; protein retention in ER lumen [GO:0006621]; protein-containing complex assembly [GO:0065003]	centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]; mitochondrion [GO:0005739]	tubulin binding [GO:0015631]	centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]; mitochondrion [GO:0005739]; tubulin binding [GO:0015631]; attachment of GPI anchor to protein [GO:0016255]; protein retention in ER lumen [GO:0006621]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Multi-pass membrane protein {ECO:0000269|PubMed:11483512}.
O43293	reviewed	DAPK3_HUMAN	Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase)	DAPK3 ZIPK	Homo sapiens (Human)	454	FUNCTION: Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. {ECO:0000269|PubMed:10356987, ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833, ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528, ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639, ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835, ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036, ECO:0000269|PubMed:23454120}.	MISCELLANEOUS: [Isoform 2]: The internal splice site between exon 8 and the 3' UTR, which yields this truncated isoform, is non-canonical. {ECO:0000305}.	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to type II interferon [GO:0071346]; chromatin organization [GO:0006325]; intracellular signal transduction [GO:0035556]; negative regulation of translation [GO:0017148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of DNA-templated transcription [GO:0006355]; regulation of focal adhesion assembly [GO:0051893]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic nuclear division [GO:0007088]; regulation of myosin II filament organization [GO:0043519]; regulation of smooth muscle contraction [GO:0006940]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	ATP binding [GO:0005524]; cAMP response element binding protein binding [GO:0008140]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; ATP binding [GO:0005524]; cAMP response element binding protein binding [GO:0008140]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to type II interferon [GO:0071346]; chromatin organization [GO:0006325]; intracellular signal transduction [GO:0035556]; negative regulation of translation [GO:0017148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of DNA-templated transcription [GO:0006355]; regulation of focal adhesion assembly [GO:0051893]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic nuclear division [GO:0007088]; regulation of myosin II filament organization [GO:0043519]; regulation of smooth muscle contraction [GO:0006940]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:15910542, ECO:0000269|PubMed:20854903}. Cytoplasm {ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:15611134, ECO:0000269|PubMed:17953487, ECO:0000269|PubMed:20854903}. Note=Predominantly localizes to the cytoplasm but can shuttle between the nucleus and cytoplasm; cytoplasmic localization is promoted by phosphorylation at Thr-299 and involves Rho/Rock signaling. {ECO:0000269|PubMed:17953487, ECO:0000269|PubMed:20854903}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:17126281}. Cytoplasm {ECO:0000269|PubMed:17126281}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:17126281}. Cytoplasm {ECO:0000269|PubMed:17126281}.
O43294	reviewed	TGFI1_HUMAN	Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5)	TGFB1I1 ARA55	Homo sapiens (Human)	461	FUNCTION: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}.		cell adhesion [GO:0007155]; cell fate commitment [GO:0045165]; epithelial cell differentiation [GO:0030855]; fat cell differentiation [GO:0045444]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fat cell differentiation [GO:0045599]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; Wnt signaling pathway [GO:0016055]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]	I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; Roundabout binding [GO:0048495]; transcription coactivator activity [GO:0003713]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; Roundabout binding [GO:0048495]; transcription coactivator activity [GO:0003713]; cell adhesion [GO:0007155]; cell fate commitment [GO:0045165]; epithelial cell differentiation [GO:0030855]; fat cell differentiation [GO:0045444]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fat cell differentiation [GO:0045599]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton; colocalizes with stress fibers.
O43295	reviewed	SRGP3_HUMAN	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP)	SRGAP3 ARHGAP14 KIAA0411 KIAA1156 MEGAP SRGAP2	Homo sapiens (Human)	1099	FUNCTION: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}.		negative regulation of cell migration [GO:0030336]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; negative regulation of cell migration [GO:0030336]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	
O43296	reviewed	ZN264_HUMAN	Zinc finger protein 264	ZNF264 KIAA0412	Homo sapiens (Human)	627	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O43298	reviewed	ZBT43_HUMAN	Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x)	ZBTB43 KIAA0414 ZBTB22B ZNF297B	Homo sapiens (Human)	467	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase III general transcription initiation factor binding [GO:0001025]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase III general transcription initiation factor binding [GO:0001025]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O43299	reviewed	AP5Z1_HUMAN	AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5)	AP5Z1 KIAA0415 SPG48	Homo sapiens (Human)	807	FUNCTION: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20613862, ECO:0000269|PubMed:22022230}.		double-strand break repair via homologous recombination [GO:0000724]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; cytoplasm [GO:0005737]; late endosome [GO:0005770]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; cytoplasm [GO:0005737]; late endosome [GO:0005770]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; double-strand break repair via homologous recombination [GO:0000724]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20613862}. Nucleus {ECO:0000269|PubMed:20613862}. Note=By SDS-PAGE, 2 isoforms have been observed, the shorter seems to be predominantly nuclear and the longer is mostly cytoplasmic. {ECO:0000269|PubMed:20613862}.
O43300	reviewed	LRRT2_HUMAN	Leucine-rich repeat transmembrane neuronal protein 2 (Leucine-rich repeat neuronal 2 protein)	LRRTM2 KIAA0416 LRRN2	Homo sapiens (Human)	516	FUNCTION: Involved in the development and maintenance of excitatory synapses in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity). {ECO:0000250|UniProtKB:D4A7P2}.		long-term synaptic potentiation [GO:0060291]; negative regulation of receptor internalization [GO:0002091]; positive regulation of synapse assembly [GO:0051965]; regulation of postsynaptic density assembly [GO:0099151]; synapse organization [GO:0050808]	excitatory synapse [GO:0060076]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; postsynaptic density membrane [GO:0098839]; postsynaptic specialization membrane [GO:0099634]; Schaffer collateral - CA1 synapse [GO:0098685]	neurexin family protein binding [GO:0042043]	excitatory synapse [GO:0060076]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; postsynaptic density membrane [GO:0098839]; postsynaptic specialization membrane [GO:0099634]; Schaffer collateral - CA1 synapse [GO:0098685]; neurexin family protein binding [GO:0042043]; long-term synaptic potentiation [GO:0060291]; negative regulation of receptor internalization [GO:0002091]; positive regulation of synapse assembly [GO:0051965]; regulation of postsynaptic density assembly [GO:0099151]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized to excitatory synapses. {ECO:0000250}.
O43303	reviewed	CP110_HUMAN	Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110)	CCP110 CEP110 CP110 KIAA0419	Homo sapiens (Human)	1012	FUNCTION: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:17681131, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}.		centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; ciliary basal body organization [GO:0032053]; negative regulation of centriole elongation [GO:1903723]; negative regulation of cilium assembly [GO:1902018]; positive regulation of cilium assembly [GO:0045724]; regulation of cytokinesis [GO:0032465]	centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]		centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; ciliary basal body organization [GO:0032053]; negative regulation of centriole elongation [GO:1903723]; negative regulation of cilium assembly [GO:1902018]; positive regulation of cilium assembly [GO:0045724]; regulation of cytokinesis [GO:0032465]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:30375385}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30375385}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q7TSH4}. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24 (PubMed:21620453). Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells. In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact (By similarity). Recruited at the distal end of the mother centriole by MPHOSPH9 (PubMed:30375385). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:30375385}.
O43306	reviewed	ADCY6_HUMAN	Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase)	ADCY6 KIAA0422	Homo sapiens (Human)	1168	FUNCTION: Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity). {ECO:0000250|UniProtKB:Q01341, ECO:0000250|UniProtKB:Q03343, ECO:0000269|PubMed:17110384, ECO:0000269|PubMed:17916776}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; blood vessel diameter maintenance [GO:0097746]; cAMP biosynthetic process [GO:0006171]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to forskolin [GO:1904322]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to vasopressin [GO:1904117]; dopamine receptor signaling pathway [GO:0007212]; intracellular signal transduction [GO:0035556]; negative regulation of neuron projection development [GO:0010977]; negative regulation of urine volume [GO:0035811]; renal water homeostasis [GO:0003091]	cilium [GO:0005929]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]	cilium [GO:0005929]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; blood vessel diameter maintenance [GO:0097746]; cAMP biosynthetic process [GO:0006171]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to forskolin [GO:1904322]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to vasopressin [GO:1904117]; dopamine receptor signaling pathway [GO:0007212]; intracellular signal transduction [GO:0035556]; negative regulation of neuron projection development [GO:0010977]; negative regulation of urine volume [GO:0035811]; renal water homeostasis [GO:0003091]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17110384}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:Q01341}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q01341}.
O43307	reviewed	ARHG9_HUMAN	Rho guanine nucleotide exchange factor 9 (Collybistin) (PEM-2 homolog) (Rac/Cdc42 guanine nucleotide exchange factor 9)	ARHGEF9 ARHDH9 KIAA0424	Homo sapiens (Human)	516	FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity). {ECO:0000250|UniProtKB:Q9QX73, ECO:0000269|PubMed:10559246}.		regulation of postsynaptic specialization assembly [GO:0099150]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of postsynaptic specialization assembly [GO:0099150]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10559246}. Postsynaptic density {ECO:0000250|UniProtKB:Q3UTH8}.
O43309	reviewed	ZSC12_HUMAN	Zinc finger and SCAN domain-containing protein 12 (Zinc finger protein 305) (Zinc finger protein 96)	ZSCAN12 KIAA0426 ZNF305 ZNF96	Homo sapiens (Human)	611	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
O43310	reviewed	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	CTIF KIAA0427	Homo sapiens (Human)	598	FUNCTION: Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}.		nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translational initiation [GO:0006446]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]	RNA binding [GO:0003723]; translation activator activity [GO:0008494]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translational initiation [GO:0006446]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:19648179}.
O43312	reviewed	MTSS1_HUMAN	Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein)	MTSS1 KIAA0429 MIM	Homo sapiens (Human)	755	FUNCTION: May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.		actin cytoskeleton organization [GO:0030036]; adherens junction maintenance [GO:0034334]; cell adhesion [GO:0007155]; cellular response to fluid shear stress [GO:0071498]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; glomerulus morphogenesis [GO:0072102]; microspike assembly [GO:0030035]; negative regulation of epithelial cell proliferation [GO:0050680]; nephron tubule epithelial cell differentiation [GO:0072160]; plasma membrane organization [GO:0007009]; positive regulation of actin filament bundle assembly [GO:0032233]; renal tubule morphogenesis [GO:0061333]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; ruffle [GO:0001726]	actin binding [GO:0003779]; actin monomer binding [GO:0003785]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; ruffle [GO:0001726]; actin binding [GO:0003779]; actin monomer binding [GO:0003785]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102]; actin cytoskeleton organization [GO:0030036]; adherens junction maintenance [GO:0034334]; cell adhesion [GO:0007155]; cellular response to fluid shear stress [GO:0071498]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; glomerulus morphogenesis [GO:0072102]; microspike assembly [GO:0030035]; negative regulation of epithelial cell proliferation [GO:0050680]; nephron tubule epithelial cell differentiation [GO:0072160]; plasma membrane organization [GO:0007009]; positive regulation of actin filament bundle assembly [GO:0032233]; renal tubule morphogenesis [GO:0061333]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
O43313	reviewed	ATMIN_HUMAN	ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ) (Zinc finger protein 822)	ATMIN KIAA0431 ZNF822	Homo sapiens (Human)	823	FUNCTION: Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. {ECO:0000269|PubMed:15933716, ECO:0000269|PubMed:17525732, ECO:0000269|PubMed:22167198}.		DNA damage response [GO:0006974]; motile cilium assembly [GO:0044458]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of non-motile cilium assembly [GO:1902857]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear body [GO:0016604]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; dynein complex binding [GO:0070840]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]	nuclear body [GO:0016604]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; dynein complex binding [GO:0070840]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; DNA damage response [GO:0006974]; motile cilium assembly [GO:0044458]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of non-motile cilium assembly [GO:1902857]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15933716, ECO:0000269|PubMed:17525732}. Note=Nuclear, in discrete foci during G1 phase.
O43314	reviewed	VIP2_HUMAN	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2)	PPIP5K2 HISPPD1 KIAA0433 VIP2	Homo sapiens (Human)	1243	FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}.		inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; phosphorylation [GO:0016310]; sensory perception of sound [GO:0007605]	cytosol [GO:0005829]	ATP binding [GO:0005524]; diphosphoinositol-pentakisphosphate kinase activity [GO:0033857]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 3-kinase activity [GO:0052724]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]	cytosol [GO:0005829]; ATP binding [GO:0005524]; diphosphoinositol-pentakisphosphate kinase activity [GO:0033857]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 3-kinase activity [GO:0052724]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]; inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; phosphorylation [GO:0016310]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17690096}.
O43315	reviewed	AQP9_HUMAN	Aquaporin-9 (AQP-9) (Aquaglyceroporin-9) (Small solute channel 1)	AQP9 SSC1	Homo sapiens (Human)	295	FUNCTION: Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines. {ECO:0000269|PubMed:10564231, ECO:0000269|PubMed:30420639, ECO:0000269|PubMed:9514918}.		amine transport [GO:0015837]; canalicular bile acid transport [GO:0015722]; cellular response to cAMP [GO:0071320]; glycerol transmembrane transport [GO:0015793]; purine nucleobase transport [GO:0006863]; pyrimidine nucleobase transport [GO:0015855]; response to pain [GO:0048265]; urea transmembrane transport [GO:0071918]; water transport [GO:0006833]	basolateral plasma membrane [GO:0016323]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	glycerol channel activity [GO:0015254]; purine nucleobase transmembrane transporter activity [GO:0005345]; pyrimidine nucleobase transmembrane transporter activity [GO:0005350]; urea channel activity [GO:0015265]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250]	basolateral plasma membrane [GO:0016323]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; glycerol channel activity [GO:0015254]; purine nucleobase transmembrane transporter activity [GO:0005345]; pyrimidine nucleobase transmembrane transporter activity [GO:0005350]; urea channel activity [GO:0015265]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250]; amine transport [GO:0015837]; canalicular bile acid transport [GO:0015722]; cellular response to cAMP [GO:0071320]; glycerol transmembrane transport [GO:0015793]; purine nucleobase transport [GO:0006863]; pyrimidine nucleobase transport [GO:0015855]; response to pain [GO:0048265]; urea transmembrane transport [GO:0071918]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10564231, ECO:0000269|PubMed:9514918}; Multi-pass membrane protein {ECO:0000305}.
O43316	reviewed	PAX4_HUMAN	Paired box protein Pax-4	PAX4	Homo sapiens (Human)	350	FUNCTION: Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.		anatomical structure development [GO:0048856]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure development [GO:0048856]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
O43318	reviewed	M3K7_HUMAN	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)	MAP3K7 TAK1	Homo sapiens (Human)	606	FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:9079627, PubMed:16893890). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:8663074, PubMed:11460167). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:8663074, PubMed:11460167, PubMed:12589052). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:8663074, PubMed:12589052). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}.		activation of NF-kappaB-inducing kinase activity [GO:0007250]; anoikis [GO:0043276]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to angiotensin [GO:1904385]; cellular response to oxygen-glucose deprivation [GO:0090650]; cellular response to tumor necrosis factor [GO:0071356]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to bacterium [GO:0042742]; Fc-epsilon receptor signaling pathway [GO:0038095]; histone H3 acetylation [GO:0043966]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-17A-mediated signaling pathway [GO:0038173]; interleukin-33-mediated signaling pathway [GO:0038172]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of gene expression [GO:0010629]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; p38MAPK cascade [GO:0038066]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell size [GO:0045793]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macroautophagy [GO:0016239]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; response to hypoxia [GO:0001666]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; transforming growth factor beta receptor signaling pathway [GO:0007179]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	ATAC complex [GO:0140672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; histone kinase activity [GO:0035173]; identical protein binding [GO:0042802]; linear polyubiquitin binding [GO:1990450]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; MAP kinase kinase kinase activity [GO:0004709]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase binding [GO:0120283]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; transcription coactivator binding [GO:0001223]; type II transforming growth factor beta receptor binding [GO:0005114]; ubiquitin protein ligase binding [GO:0031625]	ATAC complex [GO:0140672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; histone kinase activity [GO:0035173]; identical protein binding [GO:0042802]; linear polyubiquitin binding [GO:1990450]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; MAP kinase kinase kinase activity [GO:0004709]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase binding [GO:0120283]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; transcription coactivator binding [GO:0001223]; type II transforming growth factor beta receptor binding [GO:0005114]; ubiquitin protein ligase binding [GO:0031625]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; anoikis [GO:0043276]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to angiotensin [GO:1904385]; cellular response to oxygen-glucose deprivation [GO:0090650]; cellular response to tumor necrosis factor [GO:0071356]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to bacterium [GO:0042742]; Fc-epsilon receptor signaling pathway [GO:0038095]; histone H3 acetylation [GO:0043966]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-17A-mediated signaling pathway [GO:0038173]; interleukin-33-mediated signaling pathway [GO:0038172]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of gene expression [GO:0010629]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; p38MAPK cascade [GO:0038066]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell size [GO:0045793]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macroautophagy [GO:0016239]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; response to hypoxia [GO:0001666]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; transforming growth factor beta receptor signaling pathway [GO:0007179]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12242293}. Cell membrane {ECO:0000269|PubMed:12242293}; Peripheral membrane protein {ECO:0000269|PubMed:12242293}; Cytoplasmic side {ECO:0000269|PubMed:12242293}. Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.
O43320	reviewed	FGF16_HUMAN	Fibroblast growth factor 16 (FGF-16)	FGF16	Homo sapiens (Human)	207	FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. {ECO:0000269|PubMed:16597617}.		animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; response to temperature stimulus [GO:0009266]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; response to temperature stimulus [GO:0009266]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O54769}.
O43323	reviewed	DHH_HUMAN	Desert hedgehog protein (DHH) (EC 3.1.-.-) (HHG-3) [Cleaved into: Desert hedgehog protein N-product (DHH-N)]	DHH	Homo sapiens (Human)	396	FUNCTION: [Desert hedgehog protein]: The C-terminal part of the desert hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (N-product and C-product) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Functions in cell-cell mediated juxtacrine signaling (PubMed:24342078). Promotes endothelium integrity (PubMed:33063110). Binds to PTCH1 receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes in endothelial cells (PubMed:33063110). In Schwann cells, controls the development of the peripheral nerve sheath and the transition of mesenchymal cells to form the epithelium-like structure of the perineurial tube (By similarity). {ECO:0000250|UniProtKB:Q61488, ECO:0000250|UniProtKB:Q62226, ECO:0000269|PubMed:24342078, ECO:0000269|PubMed:33063110}.; FUNCTION: [Desert hedgehog protein N-product]: The dually lipidated desert hedgehog protein N-product is essential for a variety of patterning events during development (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (PubMed:11472839, PubMed:33063110). Required for normal testis development and spermatogenesis, namely for the formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules (By similarity). Activates primary cilia signaling on neighboring valve interstitial cells through a paracrine mechanism (By similarity). May induce motor neurons in lateral neural tube and may have a polarizing activity (PubMed:11472839). Prevents the desert hedgehog protein precursor binding to PTCH1 (PubMed:33063110). {ECO:0000250|UniProtKB:Q15465, ECO:0000250|UniProtKB:Q61488, ECO:0000250|UniProtKB:Q62226, ECO:0000269|PubMed:11472839, ECO:0000269|PubMed:33063110}.		cell fate specification [GO:0001708]; cell-cell signaling [GO:0007267]; Leydig cell differentiation [GO:0033327]; male sex determination [GO:0030238]; myelination [GO:0042552]; osteoblast differentiation [GO:0001649]; positive regulation of smoothened signaling pathway [GO:0045880]; protein autoprocessing [GO:0016540]; regulation of gene expression [GO:0010468]; regulation of steroid biosynthetic process [GO:0050810]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; self proteolysis [GO:0097264]; smoothened signaling pathway [GO:0007224]; spermatid development [GO:0007286]	endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; patched binding [GO:0005113]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270]	endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; patched binding [GO:0005113]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270]; cell fate specification [GO:0001708]; cell-cell signaling [GO:0007267]; Leydig cell differentiation [GO:0033327]; male sex determination [GO:0030238]; myelination [GO:0042552]; osteoblast differentiation [GO:0001649]; positive regulation of smoothened signaling pathway [GO:0045880]; protein autoprocessing [GO:0016540]; regulation of gene expression [GO:0010468]; regulation of steroid biosynthetic process [GO:0050810]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; self proteolysis [GO:0097264]; smoothened signaling pathway [GO:0007224]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: [Desert hedgehog protein N-product]: Cell membrane {ECO:0000250|UniProtKB:Q62226}; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}.; SUBCELLULAR LOCATION: [Desert hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15465}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15465}. Secreted {ECO:0000269|PubMed:33063110}. Cell membrane {ECO:0000269|PubMed:24342078}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q15465}.
O43324	reviewed	MCA3_HUMAN	Eukaryotic translation elongation factor 1 epsilon-1 (Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3) (Elongation factor p18) (Multisynthase complex auxiliary component p18)	EEF1E1 AIMP3 P18	Homo sapiens (Human)	174	FUNCTION: Positive modulator of ATM response to DNA damage. {ECO:0000250|UniProtKB:Q9D1M4}.		cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cellular senescence [GO:2000774]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; translation [GO:0006412]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cellular senescence [GO:2000774]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15680327}. Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}. Nucleus {ECO:0000269|PubMed:15680327}. Note=Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage.
O43353	reviewed	RIPK2_HUMAN	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)	RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092	Homo sapiens (Human)	540	FUNCTION: Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:9575181, PubMed:9642260, PubMed:14638696, PubMed:21123652, PubMed:17054981, PubMed:28656966). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments (PubMed:17562858, PubMed:21123652, PubMed:17054981, PubMed:22607974, PubMed:28656966, PubMed:29452636, PubMed:30026309). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors (PubMed:22607974, PubMed:29452636, PubMed:28545134, PubMed:30279485, PubMed:30478312, PubMed:30026309). 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (PubMed:22607974, PubMed:17562858, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB (PubMed:18079694). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18079694). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (PubMed:29452636, PubMed:30026309). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (PubMed:21887730). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181). {ECO:0000269|PubMed:14638696, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:17562858, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:21123652, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:28545134, ECO:0000269|PubMed:28656966, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:30279485, ECO:0000269|PubMed:30478312, ECO:0000269|PubMed:9575181, ECO:0000269|PubMed:9642260}.		activation of cysteine-type endopeptidase activity [GO:0097202]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to peptidoglycan [GO:0071224]; cytokine-mediated signaling pathway [GO:0019221]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; ERK1 and ERK2 cascade [GO:0070371]; immature T cell proliferation in thymus [GO:0033080]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein binding [GO:0032092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of xenophagy [GO:1904417]; protein homooligomerization [GO:0051260]; response to exogenous dsRNA [GO:0043330]; response to interleukin-1 [GO:0070555]; response to interleukin-12 [GO:0070671]; response to interleukin-18 [GO:0070673]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; xenophagy [GO:0098792]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; vesicle [GO:0031982]	ATP binding [GO:0005524]; CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; LIM domain binding [GO:0030274]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; vesicle [GO:0031982]; ATP binding [GO:0005524]; CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; LIM domain binding [GO:0030274]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; activation of cysteine-type endopeptidase activity [GO:0097202]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to peptidoglycan [GO:0071224]; cytokine-mediated signaling pathway [GO:0019221]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; ERK1 and ERK2 cascade [GO:0070371]; immature T cell proliferation in thymus [GO:0033080]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein binding [GO:0032092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of xenophagy [GO:1904417]; protein homooligomerization [GO:0051260]; response to exogenous dsRNA [GO:0043330]; response to interleukin-1 [GO:0070555]; response to interleukin-12 [GO:0070671]; response to interleukin-18 [GO:0070673]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; xenophagy [GO:0098792]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21887730}. Cell membrane {ECO:0000269|PubMed:17355968}; Peripheral membrane protein {ECO:0000305|PubMed:17355968}. Endoplasmic reticulum {ECO:0000269|PubMed:28656966}. Note=Recruited to the cell membrane by NOD2 following stimulation by bacterial peptidoglycans. {ECO:0000269|PubMed:17355968}.
O43364	reviewed	HXA2_HUMAN	Homeobox protein Hox-A2 (Homeobox protein Hox-1K)	HOXA2 HOX1K	Homo sapiens (Human)	376	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; brain segmentation [GO:0035284]; cell fate determination [GO:0001709]; cellular response to retinoic acid [GO:0071300]; dorsal/ventral pattern formation [GO:0009953]; embryonic viscerocranium morphogenesis [GO:0048703]; middle ear morphogenesis [GO:0042474]; motor neuron axon guidance [GO:0008045]; muscle structure development [GO:0061061]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of osteoblast differentiation [GO:0045668]; osteoblast development [GO:0002076]; pharyngeal system development [GO:0060037]; positive regulation of transcription by RNA polymerase II [GO:0045944]; rhombomere 2 development [GO:0021568]; rhombomere 3 morphogenesis [GO:0021658]; segment specification [GO:0007379]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; brain segmentation [GO:0035284]; cell fate determination [GO:0001709]; cellular response to retinoic acid [GO:0071300]; dorsal/ventral pattern formation [GO:0009953]; embryonic viscerocranium morphogenesis [GO:0048703]; middle ear morphogenesis [GO:0042474]; motor neuron axon guidance [GO:0008045]; muscle structure development [GO:0061061]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of osteoblast differentiation [GO:0045668]; osteoblast development [GO:0002076]; pharyngeal system development [GO:0060037]; positive regulation of transcription by RNA polymerase II [GO:0045944]; rhombomere 2 development [GO:0021568]; rhombomere 3 morphogenesis [GO:0021658]; segment specification [GO:0007379]	SUBCELLULAR LOCATION: Nucleus.
O43365	reviewed	HXA3_HUMAN	Homeobox protein Hox-A3 (Homeobox protein Hox-1E)	HOXA3 HOX1E	Homo sapiens (Human)	443	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		angiogenesis [GO:0001525]; animal organ formation [GO:0048645]; anterior/posterior pattern specification [GO:0009952]; blood vessel remodeling [GO:0001974]; cartilage development [GO:0051216]; embryonic skeletal system morphogenesis [GO:0048704]; gene expression [GO:0010467]; glossopharyngeal nerve morphogenesis [GO:0021615]; parathyroid gland development [GO:0060017]; positive regulation of stem cell proliferation [GO:2000648]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of animal organ position [GO:0010159]; stem cell proliferation [GO:0072089]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; angiogenesis [GO:0001525]; animal organ formation [GO:0048645]; anterior/posterior pattern specification [GO:0009952]; blood vessel remodeling [GO:0001974]; cartilage development [GO:0051216]; embryonic skeletal system morphogenesis [GO:0048704]; gene expression [GO:0010467]; glossopharyngeal nerve morphogenesis [GO:0021615]; parathyroid gland development [GO:0060017]; positive regulation of stem cell proliferation [GO:2000648]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of animal organ position [GO:0010159]; stem cell proliferation [GO:0072089]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]	SUBCELLULAR LOCATION: Nucleus.
O43374	reviewed	RASL2_HUMAN	Ras GTPase-activating protein 4 (Calcium-promoted Ras inactivator) (Ras p21 protein activator 4) (RasGAP-activating-like protein 2)	RASA4 CAPRI GAPL KIAA0538	Homo sapiens (Human)	803	FUNCTION: Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. {ECO:0000269|PubMed:11448776}.		cellular response to calcium ion [GO:0071277]; intracellular signal transduction [GO:0035556]; negative regulation of GTPase activity [GO:0034260]; negative regulation of Ras protein signal transduction [GO:0046580]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; cellular response to calcium ion [GO:0071277]; intracellular signal transduction [GO:0035556]; negative regulation of GTPase activity [GO:0034260]; negative regulation of Ras protein signal transduction [GO:0046580]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11448776}. Cell membrane {ECO:0000269|PubMed:11448776}; Peripheral membrane protein {ECO:0000269|PubMed:11448776}. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.
O43379	reviewed	WDR62_HUMAN	WD repeat-containing protein 62	WDR62 C19orf14	Homo sapiens (Human)	1518	FUNCTION: Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	centriole replication [GO:0007099]; cerebral cortex development [GO:0021987]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron migration [GO:2001224]; regulation of centrosome cycle [GO:0046605]; regulation of neuron differentiation [GO:0045664]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; spindle pole [GO:0000922]		centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; spindle pole [GO:0000922]; centriole replication [GO:0007099]; cerebral cortex development [GO:0021987]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron migration [GO:2001224]; regulation of centrosome cycle [GO:0046605]; regulation of neuron differentiation [GO:0045664]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:21496009}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:20890279, ECO:0000269|PubMed:28089251}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:21496009, ECO:0000269|PubMed:26297806}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26297806}. Note=Shows cell cycle-dependent localization. Accumulates to the spindle pole during mitosis. Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. {ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}.
O43390	reviewed	HNRPR_HUMAN	Heterogeneous nuclear ribonucleoprotein R (hnRNP R)	HNRNPR HNRPR	Homo sapiens (Human)	633	FUNCTION: Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.	MISCELLANEOUS: [Isoform 3]: Expression is low and neural-specific. {ECO:0000305}.	circadian rhythm [GO:0007623]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]	axon terminus [GO:0043679]; catalytic step 2 spliceosome [GO:0071013]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]	mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	axon terminus [GO:0043679]; catalytic step 2 spliceosome [GO:0071013]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; circadian rhythm [GO:0007623]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31079900}. Microsome {ECO:0000250|UniProtKB:Q7TMK9}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17289661}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). {ECO:0000250|UniProtKB:Q7TMK9, ECO:0000269|PubMed:17289661}.
O43395	reviewed	PRPF3_HUMAN	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein)	PRPF3 HPRP3 PRP3	Homo sapiens (Human)	683	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000305|PubMed:20595234}.		mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]	Cajal body [GO:0015030]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	Cajal body [GO:0015030]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17932117, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9328476, ECO:0000269|PubMed:9404889}. Nucleus speckle.
O43396	reviewed	TXNL1_HUMAN	Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein)	TXNL1 TRP32 TXL TXNL	Homo sapiens (Human)	289	FUNCTION: Active thioredoxin with a redox potential of about -250 mV. {ECO:0000269|PubMed:19349277}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome complex [GO:0000502]	disulfide oxidoreductase activity [GO:0015036]; protein-disulfide reductase activity [GO:0015035]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; disulfide oxidoreductase activity [GO:0015036]; protein-disulfide reductase activity [GO:0015035]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19349277}. Nucleus {ECO:0000269|PubMed:19349277}. Note=At least 85% of the cellular TXNL1 is proteasome-associated.
O43399	reviewed	TPD54_HUMAN	Tumor protein D54 (hD54) (Tumor protein D52-like 2)	TPD52L2	Homo sapiens (Human)	206			carbohydrate metabolic process [GO:0005975]; regulation of cell population proliferation [GO:0042127]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]	protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; carbohydrate metabolic process [GO:0005975]; regulation of cell population proliferation [GO:0042127]	
O43402	reviewed	EMC8_HUMAN	ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B)	EMC8 C16orf2 C16orf4 COX4AL COX4NB FAM158B NOC4	Homo sapiens (Human)	210	FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305}.		protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	cytoplasm [GO:0005737]; EMC complex [GO:0072546]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]		cytoplasm [GO:0005737]; EMC complex [GO:0072546]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Peripheral membrane protein {ECO:0000305|PubMed:32439656}; Cytoplasmic side {ECO:0000269|PubMed:32439656}.
O43405	reviewed	COCH_HUMAN	Cochlin (COCH-5B2)	COCH COCH5B2 UNQ257/PRO294	Homo sapiens (Human)	550	FUNCTION: Plays a role in the control of cell shape and motility in the trabecular meshwork. {ECO:0000269|PubMed:21886777}.		regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]	collagen binding [GO:0005518]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; collagen binding [GO:0005518]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12843317, ECO:0000269|PubMed:22610276}.
O43422	reviewed	P52K_HUMAN	52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (Death-associated protein 4) (THAP domain-containing protein 0) (THAP domain-containing protein 12)	THAP12 DAP4 P52RIPK PRKRIR THAP0	Homo sapiens (Human)	761	FUNCTION: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.		negative regulation of cell population proliferation [GO:0008285]; signal transduction [GO:0007165]	nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]	nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; negative regulation of cell population proliferation [GO:0008285]; signal transduction [GO:0007165]	
O43424	reviewed	GRID2_HUMAN	Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit)	GRID2 GLURD2	Homo sapiens (Human)	1007	FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511). {ECO:0000269|PubMed:27418511}.		cerebellar granule cell differentiation [GO:0021707]; excitatory postsynaptic potential [GO:0060079]; excitatory synapse assembly [GO:1904861]; glutamate receptor signaling pathway [GO:0007215]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; prepulse inhibition [GO:0060134]; protein localization [GO:0008104]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuron projection development [GO:0010975]; regulation of postsynaptic density assembly [GO:0099151]; synaptic transmission, glutamatergic [GO:0035249]	dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; ionotropic glutamate receptor complex [GO:0008328]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; synapse [GO:0045202]	glutamate receptor activity [GO:0008066]; ionotropic glutamate receptor activity [GO:0004970]; PDZ domain binding [GO:0030165]; scaffold protein binding [GO:0097110]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; ionotropic glutamate receptor complex [GO:0008328]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; synapse [GO:0045202]; glutamate receptor activity [GO:0008066]; ionotropic glutamate receptor activity [GO:0004970]; PDZ domain binding [GO:0030165]; scaffold protein binding [GO:0097110]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; cerebellar granule cell differentiation [GO:0021707]; excitatory postsynaptic potential [GO:0060079]; excitatory synapse assembly [GO:1904861]; glutamate receptor signaling pathway [GO:0007215]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; prepulse inhibition [GO:0060134]; protein localization [GO:0008104]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuron projection development [GO:0010975]; regulation of postsynaptic density assembly [GO:0099151]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
O43426	reviewed	SYNJ1_HUMAN	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)	SYNJ1 KIAA0910	Homo sapiens (Human)	1573	FUNCTION: Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:27435091}.		inositol phosphate metabolic process [GO:0043647]; learning [GO:0007612]; membrane organization [GO:0061024]; neurotransmitter transport [GO:0006836]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol metabolic process [GO:0046488]; positive regulation of endosome organization [GO:1904980]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle priming [GO:0016082]; synaptic vesicle transport [GO:0048489]; synaptic vesicle uncoating [GO:0016191]	clathrin coat of coated pit [GO:0030132]; cytosol [GO:0005829]; membrane coat [GO:0030117]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; synaptic membrane [GO:0097060]; terminal bouton [GO:0043195]; vesicle membrane [GO:0012506]	inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]	clathrin coat of coated pit [GO:0030132]; cytosol [GO:0005829]; membrane coat [GO:0030117]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; synaptic membrane [GO:0097060]; terminal bouton [GO:0043195]; vesicle membrane [GO:0012506]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]; inositol phosphate metabolic process [GO:0043647]; learning [GO:0007612]; membrane organization [GO:0061024]; neurotransmitter transport [GO:0006836]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol metabolic process [GO:0046488]; positive regulation of endosome organization [GO:1904980]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle priming [GO:0016082]; synaptic vesicle transport [GO:0048489]; synaptic vesicle uncoating [GO:0016191]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O18964}.
O43427	reviewed	FIBP_HUMAN	Acidic fibroblast growth factor intracellular-binding protein (aFGF intracellular-binding protein) (FGF-1 intracellular-binding protein)	FIBP	Homo sapiens (Human)	364	FUNCTION: May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity). {ECO:0000250|UniProtKB:Q6T938, ECO:0000269|PubMed:9806903}.		fibroblast growth factor receptor signaling pathway [GO:0008543]; platelet aggregation [GO:0070527]	endomembrane system [GO:0012505]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	fibroblast growth factor binding [GO:0017134]	endomembrane system [GO:0012505]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor signaling pathway [GO:0008543]; platelet aggregation [GO:0070527]	SUBCELLULAR LOCATION: Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria.
O43432	reviewed	IF4G3_HUMAN	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII)	EIF4G3	Homo sapiens (Human)	1585	FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}.		positive regulation of translation [GO:0045727]; regulation of translational initiation [GO:0006446]; spermatid development [GO:0007286]; translational initiation [GO:0006413]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; intracellular non-membrane-bounded organelle [GO:0043232]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; intracellular non-membrane-bounded organelle [GO:0043232]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; positive regulation of translation [GO:0045727]; regulation of translational initiation [GO:0006446]; spermatid development [GO:0007286]; translational initiation [GO:0006413]	
O43435	reviewed	TBX1_HUMAN	T-box transcription factor TBX1 (T-box protein 1) (Testis-specific T-box protein)	TBX1	Homo sapiens (Human)	398	FUNCTION: Transcription factor that plays a key role in cardiovascular development by promoting pharyngeal arch segmentation during embryonic development (By similarity). Also involved in craniofacial muscle development (By similarity). Together with NKX2-5, acts as a regulator of asymmetric cardiac morphogenesis by promoting expression of PITX2 (By similarity). Acts upstream of TBX1 for the formation of the thymus and parathyroid glands from the third pharyngeal pouch (By similarity). Required for hair follicle stem cell self-renewal (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence (PubMed:11111039, PubMed:22095455). {ECO:0000250|UniProtKB:P70323, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:22095455}.		angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; aorta morphogenesis [GO:0035909]; artery morphogenesis [GO:0048844]; blood vessel development [GO:0001568]; blood vessel morphogenesis [GO:0048514]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to retinoic acid [GO:0071300]; cochlea morphogenesis [GO:0090103]; coronary artery morphogenesis [GO:0060982]; determination of left/right symmetry [GO:0007368]; ear morphogenesis [GO:0042471]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic viscerocranium morphogenesis [GO:0048703]; enamel mineralization [GO:0070166]; epithelial cell differentiation [GO:0030855]; face morphogenesis [GO:0060325]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; lymph vessel development [GO:0001945]; mesenchymal cell apoptotic process [GO:0097152]; mesoderm development [GO:0007498]; middle ear morphogenesis [GO:0042474]; muscle cell fate commitment [GO:0042693]; muscle organ development [GO:0007517]; muscle organ morphogenesis [GO:0048644]; muscle tissue morphogenesis [GO:0060415]; negative regulation of cell differentiation [GO:0045596]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; neural crest cell migration [GO:0001755]; odontogenesis of dentin-containing tooth [GO:0042475]; outer ear morphogenesis [GO:0042473]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; parathyroid gland development [GO:0060017]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of tongue muscle cell differentiation [GO:2001037]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of animal organ morphogenesis [GO:2000027]; regulation of transcription by RNA polymerase II [GO:0006357]; retinoic acid receptor signaling pathway [GO:0048384]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; soft palate development [GO:0060023]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; tongue morphogenesis [GO:0043587]; vagus nerve morphogenesis [GO:0021644]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; aorta morphogenesis [GO:0035909]; artery morphogenesis [GO:0048844]; blood vessel development [GO:0001568]; blood vessel morphogenesis [GO:0048514]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to retinoic acid [GO:0071300]; cochlea morphogenesis [GO:0090103]; coronary artery morphogenesis [GO:0060982]; determination of left/right symmetry [GO:0007368]; ear morphogenesis [GO:0042471]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic viscerocranium morphogenesis [GO:0048703]; enamel mineralization [GO:0070166]; epithelial cell differentiation [GO:0030855]; face morphogenesis [GO:0060325]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; lymph vessel development [GO:0001945]; mesenchymal cell apoptotic process [GO:0097152]; mesoderm development [GO:0007498]; middle ear morphogenesis [GO:0042474]; muscle cell fate commitment [GO:0042693]; muscle organ development [GO:0007517]; muscle organ morphogenesis [GO:0048644]; muscle tissue morphogenesis [GO:0060415]; negative regulation of cell differentiation [GO:0045596]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; neural crest cell migration [GO:0001755]; odontogenesis of dentin-containing tooth [GO:0042475]; outer ear morphogenesis [GO:0042473]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; parathyroid gland development [GO:0060017]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of tongue muscle cell differentiation [GO:2001037]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of animal organ morphogenesis [GO:2000027]; regulation of transcription by RNA polymerase II [GO:0006357]; retinoic acid receptor signaling pathway [GO:0048384]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; soft palate development [GO:0060023]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; tongue morphogenesis [GO:0043587]; vagus nerve morphogenesis [GO:0021644]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
O43439	reviewed	MTG8R_HUMAN	Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85)	CBFA2T2 EHT MTGR1	Homo sapiens (Human)	604	FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.		DNA-templated transcription [GO:0006351]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron projection development [GO:0010977]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of neuron projection development [GO:0010976]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; DNA-templated transcription [GO:0006351]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron projection development [GO:0010977]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of neuron projection development [GO:0010976]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O43447	reviewed	PPIH_HUMAN	Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP)	PPIH CYP20 CYPH	Homo sapiens (Human)	177	FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. {ECO:0000269|PubMed:11823439, ECO:0000269|PubMed:12875835, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:9570313}.		mRNA splicing, via spliceosome [GO:0000398]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; protein-containing complex assembly [GO:0065003]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; ribonucleoprotein complex binding [GO:0043021]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; ribonucleoprotein complex binding [GO:0043021]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:9570313}. Cytoplasm {ECO:0000269|PubMed:9570313}. Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic.
O43451	reviewed	MGA_HUMAN	Maltase-glucoamylase (Alpha-1,4-glucosidase) (EC 3.2.1.20)	MGAM MGA MGAML	Homo sapiens (Human)	2753	FUNCTION: Alpha-(1,4) exo-glucosidase involved in breakdown of dietary starch oligosaccharides in small intestine. Cleaves the non-reducing alpha-(1,4)-linked glucose residue in linear dextrins with retention of anomeric center stereochemistry (PubMed:12547908, PubMed:18356321, PubMed:27480812, PubMed:18036614, PubMed:22058037). Mainly hydrolyzes short length oligomaltoses having two to seven glucose residues (PubMed:12547908, PubMed:18356321, PubMed:27480812, PubMed:18036614, PubMed:22058037). Can cleave alpha-(1,2), alpha-(1,3) and alpha-(1,6) glycosidic linkages with lower efficiency, whereas beta glycosidic linkages are usually not hydrolyzed (PubMed:27480812). {ECO:0000269|PubMed:12547908, ECO:0000269|PubMed:18036614, ECO:0000269|PubMed:18356321, ECO:0000269|PubMed:22058037, ECO:0000269|PubMed:27480812}.	MISCELLANEOUS: The displayed isoform 2 sequence is inferred based on alignments, homology, conservation, expression and longest protein. RNA-seq transcriptomic analysis supports all introns in a single sample. No single full-size mRNA sequence supports this isoform yet, however it is clearly identified by mass spectrometry analysis. {ECO:0000305}.	dextrin catabolic process [GO:1901027]; maltose catabolic process [GO:0000025]; starch catabolic process [GO:0005983]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	alpha-1,4-glucosidase activity [GO:0004558]; amylase activity [GO:0016160]; carbohydrate binding [GO:0030246]; catalytic activity [GO:0003824]; glucan 1,4-alpha-glucosidase activity [GO:0004339]; maltose alpha-glucosidase activity [GO:0032450]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; alpha-1,4-glucosidase activity [GO:0004558]; amylase activity [GO:0016160]; carbohydrate binding [GO:0030246]; catalytic activity [GO:0003824]; glucan 1,4-alpha-glucosidase activity [GO:0004339]; maltose alpha-glucosidase activity [GO:0032450]; dextrin catabolic process [GO:1901027]; maltose catabolic process [GO:0000025]; starch catabolic process [GO:0005983]	SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type II membrane protein. Note=Brush border. {ECO:0000269|PubMed:3143729}.
O43462	reviewed	MBTP2_HUMAN	Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Sterol regulatory element-binding proteins intramembrane protease) (SREBPs intramembrane protease)	MBTPS2 S2P	Homo sapiens (Human)	519	FUNCTION: Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:11163209, PubMed:10805775). Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached (PubMed:10805775, PubMed:27380894, PubMed:9659902). Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription (PubMed:10805775, PubMed:27380894, PubMed:9659902). Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (PubMed:11163209). Involved in intramembrane proteolysis during bone formation (PubMed:27380894). In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression (PubMed:16417584). {ECO:0000269|PubMed:10805775, ECO:0000269|PubMed:11163209, ECO:0000269|PubMed:16417584, ECO:0000269|PubMed:27380894, ECO:0000269|PubMed:9659902}.		ATF6-mediated unfolded protein response [GO:0036500]; bone maturation [GO:0070977]; cholesterol metabolic process [GO:0008203]; endoplasmic reticulum unfolded protein response [GO:0030968]; membrane protein intracellular domain proteolysis [GO:0031293]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; protein maturation [GO:0051604]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of response to endoplasmic reticulum stress [GO:1905897]; response to endoplasmic reticulum stress [GO:0034976]	cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; ATF6-mediated unfolded protein response [GO:0036500]; bone maturation [GO:0070977]; cholesterol metabolic process [GO:0008203]; endoplasmic reticulum unfolded protein response [GO:0030968]; membrane protein intracellular domain proteolysis [GO:0031293]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; protein maturation [GO:0051604]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of response to endoplasmic reticulum stress [GO:1905897]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:19361614}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:19361614}. Golgi apparatus membrane {ECO:0000305|PubMed:16417584}; Multi-pass membrane protein {ECO:0000255}.
O43463	reviewed	SUV91_HUMAN	Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)	SUV39H1 KMT1A SUV39H	Homo sapiens (Human)	412	FUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. {ECO:0000269|PubMed:14765126, ECO:0000269|PubMed:16449642, ECO:0000269|PubMed:16818776, ECO:0000269|PubMed:16858404, ECO:0000269|PubMed:18004385, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:30111536}.; FUNCTION: (Microbial infection) Plays a role in defense against mycobacterial infections. Methylates M.tuberculosis HupB on 'Lys-140', probably methylates HupB of M.bovis also. Methylation has an inhibitory effect on mycobacterial growth in the host. Macrophages expressing about 60% SUV39H1 are slightly more susceptible to M.bovis or M.tuberculosis infection. Chaetocin (an inhibitor of this enzyme) increases macrophage survival of M.tuberculosis. This protein inhibits biofilm formation by M.tuberculosis via 'Lys-140' trimethylation. {ECO:0000269|PubMed:29170282}.		cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; chromatin organization [GO:0006325]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; energy homeostasis [GO:0097009]; epigenetic programming in the zygotic pronuclei [GO:0044725]; methylation [GO:0032259]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of histone deacetylation [GO:0031065]; rDNA heterochromatin formation [GO:0000183]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364]	chromatin silencing complex [GO:0005677]; chromosome, centromeric region [GO:0000775]; condensed nuclear chromosome [GO:0000794]; cytoplasmic vesicle [GO:0031410]; eNoSc complex [GO:0061773]; heterochromatin [GO:0000792]; nuclear lamina [GO:0005652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; rDNA heterochromatin [GO:0033553]	chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone methyltransferase activity [GO:0042054]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin silencing complex [GO:0005677]; chromosome, centromeric region [GO:0000775]; condensed nuclear chromosome [GO:0000794]; cytoplasmic vesicle [GO:0031410]; eNoSc complex [GO:0061773]; heterochromatin [GO:0000792]; nuclear lamina [GO:0005652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; rDNA heterochromatin [GO:0033553]; chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone methyltransferase activity [GO:0042054]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; chromatin organization [GO:0006325]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; energy homeostasis [GO:0097009]; epigenetic programming in the zygotic pronuclei [GO:0044725]; methylation [GO:0032259]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of histone deacetylation [GO:0031065]; rDNA heterochromatin formation [GO:0000183]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29170282, ECO:0000269|PubMed:30111536}. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.; SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome lumen {ECO:0000269|PubMed:29170282}. Cell membrane {ECO:0000269|PubMed:29170282}. Note=(Microbial infection) Upon infection with M.bovis most protein is found associated with bacteria in phagolysosomes, while part is also found in the cell membrane; localization requires bacterial HupB, when it is deleted SUV39H1 is not phagosomal. {ECO:0000269|PubMed:29170282}.
O43464	reviewed	HTRA2_HUMAN	Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)	HTRA2 OMI PRSS25	Homo sapiens (Human)	458	FUNCTION: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. {ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560}.		adult walking behavior [GO:0007628]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heat [GO:0034605]; cellular response to interferon-beta [GO:0035458]; cellular response to oxidative stress [GO:0034599]; cellular response to retinoic acid [GO:0071300]; ceramide metabolic process [GO:0006672]; execution phase of apoptosis [GO:0097194]; forebrain development [GO:0030900]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitochondrion organization [GO:0007005]; negative regulation of cell cycle [GO:0045786]; negative regulation of mitophagy in response to mitochondrial depolarization [GO:1904924]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; neuron apoptotic process [GO:0051402]; neuron development [GO:0048666]; pentacyclic triterpenoid metabolic process [GO:0019742]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of mitochondrion organization [GO:0010822]; positive regulation of protein targeting to mitochondrion [GO:1903955]; programmed cell death [GO:0012501]; protein autoprocessing [GO:0016540]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of multicellular organism growth [GO:0040014]; response to herbicide [GO:0009635]	CD40 receptor complex [GO:0035631]; chromatin [GO:0000785]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; serine-type endopeptidase complex [GO:1905370]	identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; unfolded protein binding [GO:0051082]	CD40 receptor complex [GO:0035631]; chromatin [GO:0000785]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; serine-type endopeptidase complex [GO:1905370]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; unfolded protein binding [GO:0051082]; adult walking behavior [GO:0007628]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heat [GO:0034605]; cellular response to interferon-beta [GO:0035458]; cellular response to oxidative stress [GO:0034599]; cellular response to retinoic acid [GO:0071300]; ceramide metabolic process [GO:0006672]; execution phase of apoptosis [GO:0097194]; forebrain development [GO:0030900]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitochondrion organization [GO:0007005]; negative regulation of cell cycle [GO:0045786]; negative regulation of mitophagy in response to mitochondrial depolarization [GO:1904924]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; neuron apoptotic process [GO:0051402]; neuron development [GO:0048666]; pentacyclic triterpenoid metabolic process [GO:0019742]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of mitochondrion organization [GO:0010822]; positive regulation of protein targeting to mitochondrion [GO:1903955]; programmed cell death [GO:0012501]; protein autoprocessing [GO:0016540]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of multicellular organism growth [GO:0040014]; response to herbicide [GO:0009635]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum {ECO:0000269|PubMed:10644717}.
O43474	reviewed	KLF4_HUMAN	Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor)	KLF4 EZF GKLF	Homo sapiens (Human)	513	FUNCTION: Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. {ECO:0000269|PubMed:17308127, ECO:0000269|PubMed:20071344}.		canonical Wnt signaling pathway [GO:0060070]; cellular response to growth factor stimulus [GO:0071363]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to leukemia inhibitory factor [GO:1990830]; defense response to tumor cell [GO:0002357]; epidermal cell differentiation [GO:0009913]; epidermis morphogenesis [GO:0048730]; establishment of skin barrier [GO:0061436]; fat cell differentiation [GO:0045444]; glandular epithelial cell differentiation [GO:0002067]; mesodermal cell fate determination [GO:0007500]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of leukocyte adhesion to arterial endothelial cell [GO:1904998]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic camera-type eye development [GO:0031077]; post-embryonic hemopoiesis [GO:0035166]; regulation of axon regeneration [GO:0048679]; regulation of blastocyst development [GO:0120222]; regulation of cell differentiation [GO:0045595]; regulation of transcription by RNA polymerase II [GO:0006357]; response to retinoic acid [GO:0032526]; somatic stem cell population maintenance [GO:0035019]; stem cell population maintenance [GO:0019827]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytosol [GO:0005829]; euchromatin [GO:0000791]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [GO:0001010]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; euchromatin [GO:0000791]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [GO:0001010]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; canonical Wnt signaling pathway [GO:0060070]; cellular response to growth factor stimulus [GO:0071363]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to leukemia inhibitory factor [GO:1990830]; defense response to tumor cell [GO:0002357]; epidermal cell differentiation [GO:0009913]; epidermis morphogenesis [GO:0048730]; establishment of skin barrier [GO:0061436]; fat cell differentiation [GO:0045444]; glandular epithelial cell differentiation [GO:0002067]; mesodermal cell fate determination [GO:0007500]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of leukocyte adhesion to arterial endothelial cell [GO:1904998]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic camera-type eye development [GO:0031077]; post-embryonic hemopoiesis [GO:0035166]; regulation of axon regeneration [GO:0048679]; regulation of blastocyst development [GO:0120222]; regulation of cell differentiation [GO:0045595]; regulation of transcription by RNA polymerase II [GO:0006357]; response to retinoic acid [GO:0032526]; somatic stem cell population maintenance [GO:0035019]; stem cell population maintenance [GO:0019827]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q60793}. Cytoplasm {ECO:0000250|UniProtKB:Q60793}.
O43482	reviewed	MS18B_HUMAN	Protein Mis18-beta (Cancer/testis antigen 86) (CT86) (Opa-interacting protein 5) (OIP-5)	OIP5 MIS18B	Homo sapiens (Human)	229	FUNCTION: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}.		cell communication [GO:0007154]; cell division [GO:0051301]; CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]	Cajal body [GO:0015030]; chromatin [GO:0000785]; chromocenter [GO:0010369]; chromosome, centromeric region [GO:0000775]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	Cajal body [GO:0015030]; chromatin [GO:0000785]; chromocenter [GO:0010369]; chromosome, centromeric region [GO:0000775]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; cell communication [GO:0007154]; cell division [GO:0051301]; CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17199038}. Chromosome {ECO:0000269|PubMed:17199038}. Chromosome, centromere {ECO:0000269|PubMed:17199038}. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
O43488	reviewed	ARK72_HUMAN	Aflatoxin B1 aldehyde reductase member 2 (EC 1.1.1.n11) (AFB1 aldehyde reductase 1) (AFB1-AR 1) (Aldoketoreductase 7) (Succinic semialdehyde reductase) (SSA reductase)	AKR7A2 AFAR AFAR1 AKR7	Homo sapiens (Human)	359	FUNCTION: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:17591773, ECO:0000269|PubMed:9576847}.		carbohydrate metabolic process [GO:0005975]; cellular aldehyde metabolic process [GO:0006081]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; lipid metabolic process [GO:0006629]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]	alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; electron transfer activity [GO:0009055]; phenanthrene-9,10-epoxide hydrolase activity [GO:0019119]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; electron transfer activity [GO:0009055]; phenanthrene-9,10-epoxide hydrolase activity [GO:0019119]; carbohydrate metabolic process [GO:0005975]; cellular aldehyde metabolic process [GO:0006081]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255}. Golgi apparatus {ECO:0000250|UniProtKB:Q8CG45}. Cytoplasm {ECO:0000269|PubMed:9576847}.
O43490	reviewed	PROM1_HUMAN	Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133)	PROM1 PROML1 MSTP061	Homo sapiens (Human)	865	FUNCTION: May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439). {ECO:0000269|PubMed:20818439, ECO:0000269|PubMed:24556617}.	MISCELLANEOUS: Is used as marker for hematopoietic stem and progenitor cells (HSPC) for somatic stem cell isolation.	camera-type eye photoreceptor cell differentiation [GO:0060219]; glomerular parietal epithelial cell differentiation [GO:0072139]; photoreceptor cell maintenance [GO:0045494]; podocyte differentiation [GO:0072112]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; retina layer formation [GO:0010842]; retina morphogenesis in camera-type eye [GO:0060042]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; prominosome [GO:0071914]; vesicle [GO:0031982]	actinin binding [GO:0042805]; cadherin binding [GO:0045296]; cholesterol binding [GO:0015485]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; prominosome [GO:0071914]; vesicle [GO:0031982]; actinin binding [GO:0042805]; cadherin binding [GO:0045296]; cholesterol binding [GO:0015485]; camera-type eye photoreceptor cell differentiation [GO:0060219]; glomerular parietal epithelial cell differentiation [GO:0072139]; photoreceptor cell maintenance [GO:0045494]; podocyte differentiation [GO:0072112]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; retina layer formation [GO:0010842]; retina morphogenesis in camera-type eye [GO:0060042]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.
O43491	reviewed	E41L2_HUMAN	Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G)	EPB41L2	Homo sapiens (Human)	1005	FUNCTION: Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.		actomyosin structure organization [GO:0031032]; cell cycle [GO:0007049]; cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866]; positive regulation of protein localization to cell cortex [GO:1904778]	cell cortex [GO:0005938]; cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; spectrin [GO:0008091]	actin binding [GO:0003779]; PH domain binding [GO:0042731]; spectrin binding [GO:0030507]; structural molecule activity [GO:0005198]	cell cortex [GO:0005938]; cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; spectrin [GO:0008091]; actin binding [GO:0003779]; PH domain binding [GO:0042731]; spectrin binding [GO:0030507]; structural molecule activity [GO:0005198]; actomyosin structure organization [GO:0031032]; cell cycle [GO:0007049]; cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866]; positive regulation of protein localization to cell cortex [GO:1904778]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000269|PubMed:23870127}. Cell membrane {ECO:0000269|PubMed:22361696}.
O43493	reviewed	TGON2_HUMAN	Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2)	TGOLN2 TGN46 TGN51	Homo sapiens (Human)	437	FUNCTION: May be involved in regulating membrane traffic to and from trans-Golgi network.			clathrin-coated endocytic vesicle membrane [GO:0030669]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133]		clathrin-coated endocytic vesicle membrane [GO:0030669]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.
O43497	reviewed	CAC1G_HUMAN	Voltage-dependent T-type calcium channel subunit alpha-1G (Cav3.1c) (NBR13) (Voltage-gated calcium channel subunit alpha Cav3.1)	CACNA1G KIAA1123	Homo sapiens (Human)	2377	FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. {ECO:0000269|PubMed:10648811, ECO:0000269|PubMed:10692398, ECO:0000269|PubMed:26456284, ECO:0000269|PubMed:26715324, ECO:0000269|PubMed:29878067}.		AV node cell action potential [GO:0086016]; AV node cell to bundle of His cell signaling [GO:0086027]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cardiac muscle cell action potential involved in contraction [GO:0086002]; chemical synaptic transmission [GO:0007268]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during SA node cell action potential [GO:0086046]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to nickel cation [GO:0010045]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell signaling [GO:0086018]; sinoatrial node development [GO:0003163]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]	high voltage-gated calcium channel activity [GO:0008331]; low voltage-gated calcium channel activity [GO:0008332]; scaffold protein binding [GO:0097110]; voltage-gated calcium channel activity involved in AV node cell action potential [GO:0086056]; voltage-gated calcium channel activity involved SA node cell action potential [GO:0086059]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]; high voltage-gated calcium channel activity [GO:0008331]; low voltage-gated calcium channel activity [GO:0008332]; scaffold protein binding [GO:0097110]; voltage-gated calcium channel activity involved in AV node cell action potential [GO:0086056]; voltage-gated calcium channel activity involved SA node cell action potential [GO:0086059]; AV node cell action potential [GO:0086016]; AV node cell to bundle of His cell signaling [GO:0086027]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cardiac muscle cell action potential involved in contraction [GO:0086002]; chemical synaptic transmission [GO:0007268]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during SA node cell action potential [GO:0086046]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to nickel cation [GO:0010045]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell signaling [GO:0086018]; sinoatrial node development [GO:0003163]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26715324}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:26715324}.
O43502	reviewed	RA51C_HUMAN	DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2)	RAD51C RAD51L2	Homo sapiens (Human)	376	FUNCTION: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. {ECO:0000269|PubMed:14716019, ECO:0000269|PubMed:16215984, ECO:0000269|PubMed:16395335, ECO:0000269|PubMed:19451272, ECO:0000269|PubMed:19783859, ECO:0000269|PubMed:20413593, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.		DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; female meiosis sister chromatid cohesion [GO:0007066]; male meiosis I [GO:0007141]; meiotic DNA recombinase assembly [GO:0000707]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; sister chromatid cohesion [GO:0007062]; spermatogenesis [GO:0007283]; telomere maintenance via recombination [GO:0000722]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; Rad51C-XRCC3 complex [GO:0033065]; replication fork [GO:0005657]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; Rad51C-XRCC3 complex [GO:0033065]; replication fork [GO:0005657]; ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; female meiosis sister chromatid cohesion [GO:0007066]; male meiosis I [GO:0007141]; meiotic DNA recombinase assembly [GO:0000707]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; sister chromatid cohesion [GO:0007062]; spermatogenesis [GO:0007283]; telomere maintenance via recombination [GO:0000722]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12966089, ECO:0000269|PubMed:16215984}. Cytoplasm {ECO:0000269|PubMed:16215984}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16215984}. Mitochondrion {ECO:0000269|PubMed:20413593}. Note=DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA.
O43504	reviewed	LTOR5_HUMAN	Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5)	LAMTOR5 HBXIP XIP	Homo sapiens (Human)	91	FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:30181260, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:30181260, PubMed:29107538, PubMed:29158492, PubMed:28935770). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:30181260, PubMed:29158492). When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway (PubMed:12773388). {ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:30181260}.		cellular response to amino acid stimulus [GO:0071230]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization to lysosome [GO:0061462]; regulation of cell size [GO:0008361]; response to virus [GO:0009615]; TORC1 signaling [GO:0038202]; viral genome replication [GO:0019079]	cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; protein-containing complex [GO:0032991]; Ragulator complex [GO:0071986]		cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; protein-containing complex [GO:0032991]; Ragulator complex [GO:0071986]; cellular response to amino acid stimulus [GO:0071230]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization to lysosome [GO:0061462]; regulation of cell size [GO:0008361]; response to virus [GO:0009615]; TORC1 signaling [GO:0038202]; viral genome replication [GO:0019079]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:22980980}. Cytoplasm, cytosol {ECO:0000269|PubMed:12773388}.
O43505	reviewed	B4GA1_HUMAN	Beta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) (iGnT) (N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1)	B4GAT1 B3GNT1 B3GNT6	Homo sapiens (Human)	415	FUNCTION: Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1) (PubMed:19587235, PubMed:23359570, PubMed:25279699, PubMed:25279697). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity). {ECO:0000250|UniProtKB:Q8BWP8, ECO:0000269|PubMed:19587235, ECO:0000269|PubMed:23359570, ECO:0000269|PubMed:25279697, ECO:0000269|PubMed:25279699}.		axon guidance [GO:0007411]; keratan sulfate biosynthetic process [GO:0018146]; protein O-linked mannosylation [GO:0035269]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	glucuronosyltransferase activity [GO:0015020]; metal ion binding [GO:0046872]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; glucuronosyltransferase activity [GO:0015020]; metal ion binding [GO:0046872]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; axon guidance [GO:0007411]; keratan sulfate biosynthetic process [GO:0018146]; protein O-linked mannosylation [GO:0035269]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19587235, ECO:0000269|PubMed:23359570, ECO:0000269|PubMed:25279699}; Single-pass type II membrane protein {ECO:0000269|PubMed:23359570}. Note=Localizes near the trans-Golgi apparatus. {ECO:0000269|PubMed:25279699}.
O43506	reviewed	ADA20_HUMAN	Disintegrin and metalloproteinase domain-containing protein 20 (ADAM 20) (EC 3.4.24.-)	ADAM20	Homo sapiens (Human)	726	FUNCTION: May be involved in sperm maturation and/or fertilization.	MISCELLANEOUS: May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human.	male gonad development [GO:0008584]; proteolysis [GO:0006508]; single fertilization [GO:0007338]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; male gonad development [GO:0008584]; proteolysis [GO:0006508]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
O43508	reviewed	TNF12_HUMAN	Tumor necrosis factor ligand superfamily member 12 (APO3 ligand) (TNF-related weak inducer of apoptosis) (TWEAK) [Cleaved into: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form]	TNFSF12 APO3L DR3LG UNQ181/PRO207	Homo sapiens (Human)	249	FUNCTION: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. {ECO:0000269|PubMed:10085077, ECO:0000269|PubMed:23667509}.	MISCELLANEOUS: [Isoform TWE-PRIL]: Based on a readthrough transcript which may produce a TWE-PRIL (TNFSF12-TNFSF13) fusion protein. Expressed at protein level in primary T-lymphocytes and monocytic cell lines. {ECO:0000305}.	angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; endothelial cell migration [GO:0043542]; extrinsic apoptotic signaling pathway [GO:0097191]; immune response [GO:0006955]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of protein catabolic process [GO:0045732]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; endothelial cell migration [GO:0043542]; extrinsic apoptotic signaling pathway [GO:0097191]; immune response [GO:0006955]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of protein catabolic process [GO:0045732]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12411489}; Single-pass type II membrane protein {ECO:0000269|PubMed:12411489}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 12, secreted form]: Secreted.; SUBCELLULAR LOCATION: [Isoform TWE-PRIL]: Cell membrane; Single-pass membrane protein.
O43511	reviewed	S26A4_HUMAN	Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4)	SLC26A4 PDS	Homo sapiens (Human)	780	FUNCTION: Sodium-independent transporter of chloride and iodide (PubMed:10192399, PubMed:12107249, PubMed:11932316, PubMed:16684826, PubMed:24051746). Mediates electroneutral chloride-bicarbonate, chloride-iodide and chloride-formate exchange with 1:1 stoichiometry (PubMed:10644529, PubMed:15155570, PubMed:35601831, PubMed:24051746). Mediates electroneutral iodide-bicarbonate exchange (By similarity). {ECO:0000250|UniProtKB:Q9R155, ECO:0000269|PubMed:10192399, ECO:0000269|PubMed:10644529, ECO:0000269|PubMed:11932316, ECO:0000269|PubMed:12107249, ECO:0000269|PubMed:15155570, ECO:0000269|PubMed:16684826, ECO:0000269|PubMed:24051746, ECO:0000269|PubMed:35601831}.		inorganic anion transport [GO:0015698]; iodide transport [GO:0015705]; monoatomic ion transport [GO:0006811]; regulation of pH [GO:0006885]; regulation of protein localization [GO:0032880]; sensory perception of sound [GO:0007605]; sulfate transport [GO:0008272]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; iodide transmembrane transporter activity [GO:0015111]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; iodide transmembrane transporter activity [GO:0015111]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; inorganic anion transport [GO:0015698]; iodide transport [GO:0015705]; monoatomic ion transport [GO:0006811]; regulation of pH [GO:0006885]; regulation of protein localization [GO:0032880]; sensory perception of sound [GO:0007605]; sulfate transport [GO:0008272]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11932316, ECO:0000269|PubMed:24051746}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:11274445, ECO:0000269|PubMed:35601831}; Multi-pass membrane protein {ECO:0000255}.
O43513	reviewed	MED7_HUMAN	Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33)	MED7 ARC34 CRSP9	Homo sapiens (Human)	233	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.		positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]; transcription initiation at RNA polymerase II promoter [GO:0006367]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ubiquitin ligase complex [GO:0000151]	transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ubiquitin ligase complex [GO:0000151]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus.
O43516	reviewed	WIPF1_HUMAN	WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)	WIPF1 WASPIP WIP	Homo sapiens (Human)	503	FUNCTION: Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}.	MISCELLANEOUS: Recruited to PIP5K-induced vesicle surfaces in the absence of functional WASL. {ECO:0000250}.	actin filament-based movement [GO:0030048]; actin polymerization or depolymerization [GO:0008154]; protein-containing complex assembly [GO:0065003]; response to other organism [GO:0051707]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; ruffle [GO:0001726]	actin binding [GO:0003779]; profilin binding [GO:0005522]; protein folding chaperone [GO:0044183]; SH3 domain binding [GO:0017124]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; ruffle [GO:0001726]; actin binding [GO:0003779]; profilin binding [GO:0005522]; protein folding chaperone [GO:0044183]; SH3 domain binding [GO:0017124]; actin filament-based movement [GO:0030048]; actin polymerization or depolymerization [GO:0008154]; protein-containing complex assembly [GO:0065003]; response to other organism [GO:0051707]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000269|PubMed:19910490}. Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity). {ECO:0000250}.
O43520	reviewed	AT8B1_HUMAN	Phospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1)	ATP8B1 ATPIC FIC1 PFIC	Homo sapiens (Human)	1251	FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:17948906). May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (By similarity). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (PubMed:20512993). Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:25239307, PubMed:27301931). Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (By similarity). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine (PubMed:20510206). Required for the preservation of cochlear hair cells in the inner ear (By similarity). May act as cardiolipin transporter during inflammatory injury (By similarity). {ECO:0000250|UniProtKB:Q148W0, ECO:0000269|PubMed:17948906, ECO:0000269|PubMed:20510206, ECO:0000269|PubMed:20512993, ECO:0000269|PubMed:25239307, ECO:0000269|PubMed:27301931}.		apical protein localization [GO:0045176]; bile acid and bile salt transport [GO:0015721]; bile acid metabolic process [GO:0008206]; Golgi organization [GO:0007030]; inner ear receptor cell development [GO:0060119]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of DNA-templated transcription [GO:0045892]; phospholipid translocation [GO:0045332]; regulation of chloride transport [GO:2001225]; regulation of microvillus assembly [GO:0032534]; regulation of plasma membrane organization [GO:1903729]; sensory perception of sound [GO:0007605]; vestibulocochlear nerve formation [GO:0021650]; xenobiotic transmembrane transport [GO:0006855]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; trans-Golgi network [GO:0005802]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; cardiolipin binding [GO:1901612]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; trans-Golgi network [GO:0005802]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; cardiolipin binding [GO:1901612]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556]; apical protein localization [GO:0045176]; bile acid and bile salt transport [GO:0015721]; bile acid metabolic process [GO:0008206]; Golgi organization [GO:0007030]; inner ear receptor cell development [GO:0060119]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of DNA-templated transcription [GO:0045892]; phospholipid translocation [GO:0045332]; regulation of chloride transport [GO:2001225]; regulation of microvillus assembly [GO:0032534]; regulation of plasma membrane organization [GO:1903729]; sensory perception of sound [GO:0007605]; vestibulocochlear nerve formation [GO:0021650]; xenobiotic transmembrane transport [GO:0006855]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17948906, ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25315773}; Multi-pass membrane protein. Apical cell membrane {ECO:0000269|PubMed:20512993}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q148W0}. Endoplasmic reticulum {ECO:0000269|PubMed:17948906, ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:21914794}. Golgi apparatus {ECO:0000269|PubMed:20961850}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A or TMEM30B (PubMed:20947505). Localizes to apical membranes in epithelial cells (PubMed:20512993). {ECO:0000269|PubMed:20512993, ECO:0000269|PubMed:20947505}.
O43521	reviewed	B2L11_HUMAN	Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)	BCL2L11 BIM	Homo sapiens (Human)	198	FUNCTION: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:15661735, ECO:0000269|PubMed:9430630}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; B cell homeostasis [GO:0001782]; cell-matrix adhesion [GO:0007160]; cellular response to glucocorticoid stimulus [GO:0071385]; developmental pigmentation [GO:0048066]; ear development [GO:0043583]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; kidney development [GO:0001822]; male gonad development [GO:0008584]; mammary gland development [GO:0030879]; meiosis I [GO:0007127]; myeloid cell homeostasis [GO:0002262]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell cycle [GO:0045787]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of T cell apoptotic process [GO:0070234]; post-embryonic animal organ morphogenesis [GO:0048563]; regulation of apoptotic process [GO:0042981]; regulation of developmental pigmentation [GO:0048070]; regulation of organ growth [GO:0046620]; response to endoplasmic reticulum stress [GO:0034976]; spermatogenesis [GO:0007283]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]; thymocyte apoptotic process [GO:0070242]; thymus development [GO:0048538]; tube formation [GO:0035148]	Bcl-2 family protein complex [GO:0097136]; BIM-BCL-2 complex [GO:0097141]; BIM-BCL-xl complex [GO:0097140]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]	Bcl-2 family protein complex [GO:0097136]; BIM-BCL-2 complex [GO:0097141]; BIM-BCL-xl complex [GO:0097140]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; B cell homeostasis [GO:0001782]; cell-matrix adhesion [GO:0007160]; cellular response to glucocorticoid stimulus [GO:0071385]; developmental pigmentation [GO:0048066]; ear development [GO:0043583]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; kidney development [GO:0001822]; male gonad development [GO:0008584]; mammary gland development [GO:0030879]; meiosis I [GO:0007127]; myeloid cell homeostasis [GO:0002262]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell cycle [GO:0045787]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of T cell apoptotic process [GO:0070234]; post-embryonic animal organ morphogenesis [GO:0048563]; regulation of apoptotic process [GO:0042981]; regulation of developmental pigmentation [GO:0048070]; regulation of organ growth [GO:0046620]; response to endoplasmic reticulum stress [GO:0034976]; spermatogenesis [GO:0007283]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]; thymocyte apoptotic process [GO:0070242]; thymus development [GO:0048538]; tube formation [GO:0035148]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with intracytoplasmic membranes. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform BimEL]: Mitochondrion. Note=Translocates from microtubules to mitochondria on loss of cell adherence.; SUBCELLULAR LOCATION: [Isoform BimL]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform BimS]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform Bim-alpha1]: Mitochondrion.
O43524	reviewed	FOXO3_HUMAN	Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)	FOXO3 FKHRL1 FOXO3A	Homo sapiens (Human)	673	FUNCTION: Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}.		apoptotic process [GO:0006915]; cellular response to glucose starvation [GO:0042149]; cellular response to oxidative stress [GO:0034599]; mitochondrial transcription [GO:0006390]; negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of muscle atrophy [GO:0014737]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; response to fatty acid [GO:0070542]; response to starvation [GO:0042594]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription repressor complex [GO:0090571]	beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; mitochondrial transcription factor activity [GO:0034246]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription repressor complex [GO:0090571]; beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; mitochondrial transcription factor activity [GO:0034246]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; apoptotic process [GO:0006915]; cellular response to glucose starvation [GO:0042149]; cellular response to oxidative stress [GO:0034599]; mitochondrial transcription [GO:0006390]; negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of muscle atrophy [GO:0014737]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; response to fatty acid [GO:0070542]; response to starvation [GO:0042594]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:22313691, ECO:0000269|PubMed:22761832, ECO:0000269|PubMed:23283301}. Nucleus {ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:22313691, ECO:0000269|PubMed:22761832, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:29445193}. Mitochondrion matrix {ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:29445193}. Mitochondrion outer membrane {ECO:0000269|PubMed:29445193}; Peripheral membrane protein {ECO:0000269|PubMed:29445193}; Cytoplasmic side {ECO:0000269|PubMed:29445193}. Note=Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106). Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106). Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity). Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, PubMed:29445193). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:29445193}.
O43525	reviewed	KCNQ3_HUMAN	Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3)	KCNQ3	Homo sapiens (Human)	872	FUNCTION: Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (PubMed:28793216). {ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:16319223, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:9872318}.		action potential initiation [GO:0099610]; apoptosome assembly [GO:0097314]; cellular response to calcium ion [GO:0071277]; cellular response to xenobiotic stimulus [GO:0071466]; chemical synaptic transmission [GO:0007268]; excitatory chemical synaptic transmission [GO:0098976]; gene expression [GO:0010467]; inhibitory chemical synaptic transmission [GO:0098977]; membrane hyperpolarization [GO:0060081]; mitochondrial depolarization [GO:0051882]; nerve development [GO:0021675]; neuron apoptotic process [GO:0051402]; neuron remodeling [GO:0016322]; neuronal action potential [GO:0019228]; potassium ion transmembrane transport [GO:0071805]; protein import into nucleus [GO:0006606]; protein targeting [GO:0006605]; psychomotor behavior [GO:0036343]; regulation of action potential firing threshold [GO:0099611]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of synaptic plasticity [GO:0048167]; response to auditory stimulus [GO:0010996]; response to organic cyclic compound [GO:0014070]; sensory perception of sound [GO:0007605]; substantia propria of cornea development [GO:1903701]	axon initial segment [GO:0043194]; cell surface [GO:0009986]; mitochondrion [GO:0005739]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]	calmodulin binding [GO:0005516]; voltage-gated potassium channel activity [GO:0005249]	axon initial segment [GO:0043194]; cell surface [GO:0009986]; mitochondrion [GO:0005739]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]; calmodulin binding [GO:0005516]; voltage-gated potassium channel activity [GO:0005249]; action potential initiation [GO:0099610]; apoptosome assembly [GO:0097314]; cellular response to calcium ion [GO:0071277]; cellular response to xenobiotic stimulus [GO:0071466]; chemical synaptic transmission [GO:0007268]; excitatory chemical synaptic transmission [GO:0098976]; gene expression [GO:0010467]; inhibitory chemical synaptic transmission [GO:0098977]; membrane hyperpolarization [GO:0060081]; mitochondrial depolarization [GO:0051882]; nerve development [GO:0021675]; neuron apoptotic process [GO:0051402]; neuron remodeling [GO:0016322]; neuronal action potential [GO:0019228]; potassium ion transmembrane transport [GO:0071805]; protein import into nucleus [GO:0006606]; protein targeting [GO:0006605]; psychomotor behavior [GO:0036343]; regulation of action potential firing threshold [GO:0099611]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of synaptic plasticity [GO:0048167]; response to auditory stimulus [GO:0010996]; response to organic cyclic compound [GO:0014070]; sensory perception of sound [GO:0007605]; substantia propria of cornea development [GO:1903701]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10788442}; Multi-pass membrane protein {ECO:0000255}.
O43526	reviewed	KCNQ2_HUMAN	Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)	KCNQ2	Homo sapiens (Human)	872	FUNCTION: Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873). KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation. {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:11572947, ECO:0000269|PubMed:12742592, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:17872363, ECO:0000269|PubMed:25740509, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:9836639}.	MISCELLANEOUS: Inclusion of isoform 6 in heteromultimers results in attenuation of potassium current. Prominent expression of isoform 6 in the developing brain may alter firing repertoires of immature neurons excitability to provide cues for proliferation rather than differentiation.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	chemical synaptic transmission [GO:0007268]; nervous system development [GO:0007399]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]	axon initial segment [GO:0043194]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]	ankyrin binding [GO:0030506]; calmodulin binding [GO:0005516]; voltage-gated potassium channel activity [GO:0005249]	axon initial segment [GO:0043194]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]; ankyrin binding [GO:0030506]; calmodulin binding [GO:0005516]; voltage-gated potassium channel activity [GO:0005249]; chemical synaptic transmission [GO:0007268]; nervous system development [GO:0007399]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10788442, ECO:0000269|PubMed:9836639}; Multi-pass membrane protein {ECO:0000255}.
O43529	reviewed	CHSTA_HUMAN	Carbohydrate sulfotransferase 10 (EC 2.8.2.-) (HNK-1 sulfotransferase) (HNK-1ST) (HNK1ST) (HuHNK-1ST)	CHST10	Homo sapiens (Human)	356	FUNCTION: Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis (PubMed:9478973). Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase. Likely defines the chain length of LG epitope, confering binding specificity to extracellular matrix components (PubMed:32149355). Plays a role in down-regulating the steroid hormones. Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility. Has a preference for glucuronyl moiety at the 3-hydroxyl group of a sterol ring rather than the 17-hydroxyl group, showing high catalytic efficiency for 17beta-estradiol 3-O-(beta-D-glucuronate) and dehydroepiandrosterone 3-O-(beta-D-glucuronate) hormones (PubMed:23269668). {ECO:0000269|PubMed:23269668, ECO:0000269|PubMed:32149355, ECO:0000269|PubMed:9478973}.		androgen metabolic process [GO:0008209]; carbohydrate biosynthetic process [GO:0016051]; cell adhesion [GO:0007155]; estrogen metabolic process [GO:0008210]; learning [GO:0007612]; long-term memory [GO:0007616]; proteoglycan biosynthetic process [GO:0030166]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	HNK-1 sulfotransferase activity [GO:0016232]; sulfotransferase activity [GO:0008146]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; HNK-1 sulfotransferase activity [GO:0016232]; sulfotransferase activity [GO:0008146]; androgen metabolic process [GO:0008209]; carbohydrate biosynthetic process [GO:0016051]; cell adhesion [GO:0007155]; estrogen metabolic process [GO:0008210]; learning [GO:0007612]; long-term memory [GO:0007616]; proteoglycan biosynthetic process [GO:0030166]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:O54702}; Single-pass type II membrane protein {ECO:0000255}.
O43541	reviewed	SMAD6_HUMAN	Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)	SMAD6 MADH6	Homo sapiens (Human)	496	FUNCTION: Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta (PubMed:9436979, PubMed:16951688, PubMed:22275001, PubMed:9759503, PubMed:10647776, PubMed:10708948, PubMed:10708949, PubMed:30848080). Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes (PubMed:16951688). Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (PubMed:9436979, PubMed:30848080). Binds to regulatory elements in target promoter regions (PubMed:16491121). {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:16951688, ECO:0000269|PubMed:22275001, ECO:0000269|PubMed:30848080, ECO:0000269|PubMed:9436979, ECO:0000303|PubMed:10647776, ECO:0000303|PubMed:10708948, ECO:0000303|PubMed:10708949, ECO:0000303|PubMed:9759503}.		anatomical structure morphogenesis [GO:0009653]; aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell-substrate adhesion [GO:0031589]; coronary vasculature development [GO:0060976]; fat cell differentiation [GO:0045444]; immune response [GO:0006955]; mitral valve morphogenesis [GO:0003183]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of miRNA transcription [GO:1902895]; pulmonary valve morphogenesis [GO:0003184]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to laminar fluid shear stress [GO:0034616]; response to lipopolysaccharide [GO:0032496]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; ventricular septum development [GO:0003281]; zygotic specification of dorsal/ventral axis [GO:0007352]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; heteromeric SMAD protein complex [GO:0071144]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; co-SMAD binding [GO:0070410]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein sequestering activity [GO:0140311]; R-SMAD binding [GO:0070412]; transcription cis-regulatory region binding [GO:0000976]; transcription regulator inhibitor activity [GO:0140416]; type I activin receptor binding [GO:0070698]; type I transforming growth factor beta receptor binding [GO:0034713]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; heteromeric SMAD protein complex [GO:0071144]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; co-SMAD binding [GO:0070410]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein sequestering activity [GO:0140311]; R-SMAD binding [GO:0070412]; transcription cis-regulatory region binding [GO:0000976]; transcription regulator inhibitor activity [GO:0140416]; type I activin receptor binding [GO:0070698]; type I transforming growth factor beta receptor binding [GO:0034713]; ubiquitin protein ligase binding [GO:0031625]; anatomical structure morphogenesis [GO:0009653]; aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell-substrate adhesion [GO:0031589]; coronary vasculature development [GO:0060976]; fat cell differentiation [GO:0045444]; immune response [GO:0006955]; mitral valve morphogenesis [GO:0003183]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of miRNA transcription [GO:1902895]; pulmonary valve morphogenesis [GO:0003184]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to laminar fluid shear stress [GO:0034616]; response to lipopolysaccharide [GO:0032496]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; ventricular septum development [GO:0003281]; zygotic specification of dorsal/ventral axis [GO:0007352]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16491121}.
O43542	reviewed	XRCC3_HUMAN	DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3)	XRCC3	Homo sapiens (Human)	346	FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. {ECO:0000269|PubMed:14716019, ECO:0000269|PubMed:20413593, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.		DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; interstrand cross-link repair [GO:0036297]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of centrosome duplication [GO:0010824]; resolution of mitotic recombination intermediates [GO:0071140]; response to organic substance [GO:0010033]; t-circle formation [GO:0090656]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomere trimming [GO:0090737]; telomeric loop disassembly [GO:0090657]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Rad51C-XRCC3 complex [GO:0033065]; replication fork [GO:0005657]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Rad51C-XRCC3 complex [GO:0033065]; replication fork [GO:0005657]; ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; interstrand cross-link repair [GO:0036297]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of centrosome duplication [GO:0010824]; resolution of mitotic recombination intermediates [GO:0071140]; response to organic substance [GO:0010033]; t-circle formation [GO:0090656]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomere trimming [GO:0090737]; telomeric loop disassembly [GO:0090657]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.
O43543	reviewed	XRCC2_HUMAN	DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2)	XRCC2	Homo sapiens (Human)	280	FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11834724, ECO:0000269|PubMed:21276791, ECO:0000269|PubMed:23149936, ECO:0000269|PubMed:27233470}.		centrosome cycle [GO:0007098]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; in utero embryonic development [GO:0001701]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; multicellular organism growth [GO:0035264]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; positive regulation of neurogenesis [GO:0050769]; regulation of fibroblast apoptotic process [GO:2000269]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; somitogenesis [GO:0001756]; strand invasion [GO:0042148]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]; ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; centrosome cycle [GO:0007098]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; in utero embryonic development [GO:0001701]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; multicellular organism growth [GO:0035264]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; positive regulation of neurogenesis [GO:0050769]; regulation of fibroblast apoptotic process [GO:2000269]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; somitogenesis [GO:0001756]; strand invasion [GO:0042148]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}.
O43548	reviewed	TGM5_HUMAN	Protein-glutamine gamma-glutamyltransferase 5 (EC 2.3.2.13) (Transglutaminase X) (TG(X)) (TGX) (TGase X) (Transglutaminase-5) (TGase-5)	TGM5 TGMX	Homo sapiens (Human)	720	FUNCTION: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.		epidermis development [GO:0008544]; protein modification process [GO:0036211]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; epidermis development [GO:0008544]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15290349}. Note=Associated with intermediate filaments.
O43556	reviewed	SGCE_HUMAN	Epsilon-sarcoglycan (Epsilon-SG)	SGCE ESG UNQ433/PRO840	Homo sapiens (Human)	437	FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.	MISCELLANEOUS: [Isoform 2]: Brain-specific. {ECO:0000305}.	cell-matrix adhesion [GO:0007160]; muscle organ development [GO:0007517]	cytoskeleton [GO:0005856]; dendrite membrane [GO:0032590]; dystrophin-associated glycoprotein complex [GO:0016010]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]		cytoskeleton [GO:0005856]; dendrite membrane [GO:0032590]; dystrophin-associated glycoprotein complex [GO:0016010]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]; cell-matrix adhesion [GO:0007160]; muscle organ development [GO:0007517]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Golgi apparatus {ECO:0000250}.
O43557	reviewed	TNF14_HUMAN	Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]	TNFSF14 HVEML LIGHT UNQ391/PRO726	Homo sapiens (Human)	240	FUNCTION: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:9462508, PubMed:10754304). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304). {ECO:0000269|PubMed:10754304, ECO:0000269|PubMed:9462508}.		apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; immune response [GO:0006955]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell chemotaxis [GO:0010820]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell costimulation [GO:0031295]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; immune response [GO:0006955]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell chemotaxis [GO:0010820]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell costimulation [GO:0031295]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 14, membrane form]: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 14, soluble form]: Secreted.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
O43559	reviewed	FRS3_HUMAN	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FGFR-signaling adaptor SNT2) (Suc1-associated neurotrophic factor target 2) (SNT-2)	FRS3	Homo sapiens (Human)	492	FUNCTION: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2. {ECO:0000269|PubMed:15094036}.		fibroblast growth factor receptor signaling pathway [GO:0008543]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	fibroblast growth factor receptor binding [GO:0005104]; identical protein binding [GO:0042802]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; fibroblast growth factor receptor binding [GO:0005104]; identical protein binding [GO:0042802]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; fibroblast growth factor receptor signaling pathway [GO:0008543]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
O43561	reviewed	LAT_HUMAN	Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)	LAT	Homo sapiens (Human)	262	FUNCTION: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:25907557, PubMed:23514740). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}.	MISCELLANEOUS: Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC, maybe by inducing the dephosphorylation of LAT.	adaptive immune response [GO:0002250]; calcium-mediated signaling [GO:0019722]; gene expression [GO:0010467]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; lymphocyte homeostasis [GO:0002260]; mast cell degranulation [GO:0043303]; positive regulation of protein kinase activity [GO:0045860]; Ras protein signal transduction [GO:0007265]; regulation of T cell activation [GO:0050863]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]	cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	protein kinase binding [GO:0019901]; signaling receptor complex adaptor activity [GO:0030159]	cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein kinase binding [GO:0019901]; signaling receptor complex adaptor activity [GO:0030159]; adaptive immune response [GO:0002250]; calcium-mediated signaling [GO:0019722]; gene expression [GO:0010467]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; lymphocyte homeostasis [GO:0002260]; mast cell degranulation [GO:0043303]; positive regulation of protein kinase activity [GO:0045860]; Ras protein signal transduction [GO:0007265]; regulation of T cell activation [GO:0050863]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}; Single-pass type III membrane protein {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}. Note=Present in lipid rafts.
O43566	reviewed	RGS14_HUMAN	Regulator of G-protein signaling 14 (RGS14)	RGS14	Homo sapiens (Human)	566	FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}.		cell division [GO:0051301]; chromosome segregation [GO:0007059]; G protein-coupled receptor signaling pathway [GO:0007186]; learning [GO:0007612]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; mitotic cell cycle [GO:0000278]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of synaptic plasticity [GO:0031914]; nucleocytoplasmic transport [GO:0006913]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of neurogenesis [GO:0050769]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to oxidative stress [GO:0006979]; spindle organization [GO:0007051]; visual learning [GO:0008542]; zygote asymmetric cell division [GO:0010070]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; nuclear body [GO:0016604]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic density [GO:0014069]; spindle [GO:0005819]; spindle pole [GO:0000922]	G-protein alpha-subunit binding [GO:0001965]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; signaling receptor complex adaptor activity [GO:0030159]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; nuclear body [GO:0016604]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic density [GO:0014069]; spindle [GO:0005819]; spindle pole [GO:0000922]; G-protein alpha-subunit binding [GO:0001965]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; signaling receptor complex adaptor activity [GO:0030159]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; G protein-coupled receptor signaling pathway [GO:0007186]; learning [GO:0007612]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; mitotic cell cycle [GO:0000278]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of synaptic plasticity [GO:0031914]; nucleocytoplasmic transport [GO:0006913]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of neurogenesis [GO:0050769]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to oxidative stress [GO:0006979]; spindle organization [GO:0007051]; visual learning [GO:0008542]; zygote asymmetric cell division [GO:0010070]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:15917656}. Membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15917656}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Postsynaptic density {ECO:0000250}. Note=Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastral mitotic apparatus and subsequently the barrel-shaped cytoplasmic bridge between the nascent nuclei of the emerging 2-cell embryo. Localizes to a perinuclear compartment near the microtubule-organizing center (MTOC). Expressed in the nucleus during interphase and segregates to the centrosomes and astral MTs during mitosis. Relocalizes to the nucleus in PML nuclear bodies in response to heat stress. Colocalizes with RIC8A in CA2 hippocampal neurons. Localizes to spindle poles during metaphase. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Recruited from the cytosol to the plasma membrane by the inactive GDP-bound forms of G(i) alpha subunits GNAI1 and GNAI3. Recruited from the cytosol to membranes by the active GTP-bound form of HRAS. Colocalizes with G(i) alpha subunit GNAI1 and RIC8A at the plasma membrane. Colocalizes with BRAF and RAF1 in both the cytoplasm and membranes (By similarity). {ECO:0000250}.
O43567	reviewed	RNF13_HUMAN	E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13)	RNF13 RZF	Homo sapiens (Human)	381	FUNCTION: E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:18794910, PubMed:23378536, PubMed:30595371). Involved in apoptosis regulation (PubMed:23378536, PubMed:30595371). Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (PubMed:23378536, PubMed:30595371). Also involved in protein trafficking and localization (PubMed:24387786). {ECO:0000269|PubMed:18794910, ECO:0000269|PubMed:23378536, ECO:0000269|PubMed:24387786, ECO:0000269|PubMed:30595371}.		organelle localization [GO:0051640]; positive regulation of stress-activated protein kinase signaling cascade [GO:0070304]; protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]	JUN kinase binding [GO:0008432]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; JUN kinase binding [GO:0008432]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; organelle localization [GO:0051640]; positive regulation of stress-activated protein kinase signaling cascade [GO:0070304]; protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18794910, ECO:0000269|PubMed:23378536, ECO:0000269|PubMed:24387786}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000305|PubMed:24387786}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000250|UniProtKB:O54965}; Single-pass type I membrane protein {ECO:0000255}. Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane. {ECO:0000250|UniProtKB:O54965}.
O43570	reviewed	CAH12_HUMAN	Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3)	CA12	Homo sapiens (Human)	354	FUNCTION: Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:26911677}.		chloride ion homeostasis [GO:0055064]; estrous cycle [GO:0044849]; one-carbon metabolic process [GO:0006730]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]; chloride ion homeostasis [GO:0055064]; estrous cycle [GO:0044849]; one-carbon metabolic process [GO:0006730]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000269|PubMed:26911677}.
O43572	reviewed	AKA10_HUMAN	A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10)	AKAP10	Homo sapiens (Human)	662	FUNCTION: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}.		protein localization [GO:0008104]; signal transduction [GO:0007165]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	protein kinase A binding [GO:0051018]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; protein kinase A binding [GO:0051018]; protein localization [GO:0008104]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11248059}. Membrane {ECO:0000269|PubMed:11248059}. Cytoplasm {ECO:0000269|PubMed:11248059}. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.
O43581	reviewed	SYT7_HUMAN	Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII)	SYT7 PCANAP7	Homo sapiens (Human)	403	FUNCTION: Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). {ECO:0000250|UniProtKB:Q62747, ECO:0000250|UniProtKB:Q9R0N7, ECO:0000269|PubMed:11342594, ECO:0000269|PubMed:15811535}.	MISCELLANEOUS: [Isoform 1]: Major isoform. {ECO:0000269|PubMed:12071850}.	calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; phagocytosis [GO:0006909]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of bone remodeling [GO:0046850]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of phagocytosis [GO:0050764]; regulation of synaptic vesicle endocytosis [GO:1900242]; short-term synaptic potentiation [GO:1990926]; synaptic vesicle recycling [GO:0036465]; vesicle fusion [GO:0006906]; vesicle-mediated cholesterol transport [GO:0090119]	axon [GO:0030424]; cytosol [GO:0005829]; dense core granule [GO:0031045]; early phagosome [GO:0032009]; extracellular exosome [GO:0070062]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]	axon [GO:0030424]; cytosol [GO:0005829]; dense core granule [GO:0031045]; early phagosome [GO:0032009]; extracellular exosome [GO:0070062]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; phagocytosis [GO:0006909]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of bone remodeling [GO:0046850]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of phagocytosis [GO:0050764]; regulation of synaptic vesicle endocytosis [GO:1900242]; short-term synaptic potentiation [GO:1990926]; synaptic vesicle recycling [GO:0036465]; vesicle fusion [GO:0006906]; vesicle-mediated cholesterol transport [GO:0090119]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q62747}; Single-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9R0N7}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9R0N7}; Single-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q9R0N7}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9R0N7}; Single-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000250|UniProtKB:Q9R0N7}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q62747}; Single-pass membrane protein {ECO:0000255}. Note=Localization to lysosomes is dependent on N-terminal palmitoylation and interaction with CD63. {ECO:0000250|UniProtKB:Q9R0N7}.
O43583	reviewed	DENR_HUMAN	Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3)	DENR DRP1 H14	Homo sapiens (Human)	198	FUNCTION: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. {ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:17878526, ECO:0000269|PubMed:20713520}.		formation of translation preinitiation complex [GO:0001731]; IRES-dependent viral translational initiation [GO:0075522]; ribosome disassembly [GO:0032790]; translation reinitiation [GO:0002188]		mRNA binding [GO:0003729]; translation initiation factor activity [GO:0003743]	mRNA binding [GO:0003729]; translation initiation factor activity [GO:0003743]; formation of translation preinitiation complex [GO:0001731]; IRES-dependent viral translational initiation [GO:0075522]; ribosome disassembly [GO:0032790]; translation reinitiation [GO:0002188]	
O43586	reviewed	PPIP1_HUMAN	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)	PSTPIP1 CD2BP1	Homo sapiens (Human)	416	FUNCTION: Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils. {ECO:0000250, ECO:0000269|PubMed:17964261, ECO:0000269|PubMed:18480402, ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:9857189}.		actin filament polymerization [GO:0030041]; cell adhesion [GO:0007155]; endocytosis [GO:0006897]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; signal transduction [GO:0007165]	actin filament [GO:0005884]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931]	actin filament binding [GO:0051015]; identical protein binding [GO:0042802]	actin filament [GO:0005884]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931]; actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; actin filament polymerization [GO:0030041]; cell adhesion [GO:0007155]; endocytosis [GO:0006897]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9857189}. Cell membrane {ECO:0000269|PubMed:18480402, ECO:0000269|PubMed:9857189}; Peripheral membrane protein {ECO:0000269|PubMed:9857189}. Cell projection, uropodium {ECO:0000269|PubMed:18480402}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P97814}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P97814}. Cleavage furrow {ECO:0000250|UniProtKB:P97814}. Note=Mainly cytoplasmic in T-cells (PubMed:9857189). Colocalizes in cluster with CD2 near the cell surface membrane in activated T-cells (PubMed:9857189). In monocytes, forms a branched filamentous network in the cytoplasm (PubMed:19584923). In transfected cells, forms relatively straight filaments radiating out from the nucleus (PubMed:19584923). Filament formation requires an intact tubulin cytoskeleton (PubMed:19584923). In migrating neutrophils, colocalizes with PIP5K1C and DNM2 to the trailing edge of the uropod in a actin-dependent manner (PubMed:18480402). Colocalized with PTPN12 in the cytoplasm and the perinuclear region. During interphase, colocalizes with F-actin in the cortical cytoskeleton, lamellipodia, and stress fibers. In dividing cells, colocalizes with the F-actin rich cytokinetic cleavage furrow. Colocalized with CD2AP and WAS in the actin cytoskeleton within the cytoplasm. Colocalized with CD2, CD2AP and WAS at the site of T-cell:APC contact (By similarity). {ECO:0000250|UniProtKB:P97814, ECO:0000269|PubMed:18480402, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:9857189}.
O43592	reviewed	XPOT_HUMAN	Exportin-T (Exportin(tRNA)) (tRNA exportin)	XPOT	Homo sapiens (Human)	962	FUNCTION: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:12138183, ECO:0000269|PubMed:9512417, ECO:0000269|PubMed:9660920}.		intracellular protein transport [GO:0006886]; tRNA export from nucleus [GO:0006409]; tRNA re-export from nucleus [GO:0071528]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]	small GTPase binding [GO:0031267]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; small GTPase binding [GO:0031267]; tRNA binding [GO:0000049]; intracellular protein transport [GO:0006886]; tRNA export from nucleus [GO:0006409]; tRNA re-export from nucleus [GO:0071528]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.
O43593	reviewed	HAIR_HUMAN	Lysine-specific demethylase hairless (EC 1.14.11.65) ([histone H3]-dimethyl-L-lysine(9) demethylase hairless)	HR	Homo sapiens (Human)	1189	FUNCTION: Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. {ECO:0000269|PubMed:24334705}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]	chromatin DNA binding [GO:0031490]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; chromatin DNA binding [GO:0031490]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
O43597	reviewed	SPY2_HUMAN	Protein sprouty homolog 2 (Spry-2)	SPRY2	Homo sapiens (Human)	315	FUNCTION: Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561). {ECO:0000250|UniProtKB:Q9QXV8, ECO:0000269|PubMed:17974561}.		animal organ development [GO:0048513]; bud elongation involved in lung branching [GO:0060449]; cell fate commitment [GO:0045165]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; ERK1 and ERK2 cascade [GO:0070371]; establishment of mitotic spindle orientation [GO:0000132]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inner ear morphogenesis [GO:0042472]; lung growth [GO:0060437]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell projection organization [GO:0031345]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of cell migration [GO:0030335]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; sensory perception of sound [GO:0007605]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; microtubule end [GO:1990752]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase inhibitor activity [GO:0030291]; ubiquitin-protein transferase inhibitor activity [GO:0055105]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; microtubule end [GO:1990752]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase inhibitor activity [GO:0030291]; ubiquitin-protein transferase inhibitor activity [GO:0055105]; animal organ development [GO:0048513]; bud elongation involved in lung branching [GO:0060449]; cell fate commitment [GO:0045165]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; ERK1 and ERK2 cascade [GO:0070371]; establishment of mitotic spindle orientation [GO:0000132]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inner ear morphogenesis [GO:0042472]; lung growth [GO:0060437]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell projection organization [GO:0031345]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of cell migration [GO:0030335]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10887178}. Cell projection, ruffle membrane {ECO:0000269|PubMed:10887178}. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). {ECO:0000269|PubMed:10887178}.
O43598	reviewed	DNPH1_HUMAN	2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (EC 3.2.2.-) (c-Myc-responsive protein RCL)	DNPH1 C6orf108 RCL	Homo sapiens (Human)	174	FUNCTION: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. {ECO:0000255|HAMAP-Rule:MF_03036, ECO:0000269|PubMed:24260472, ECO:0000269|PubMed:25108359}.		deoxyribonucleoside monophosphate catabolic process [GO:0009159]; epithelial cell differentiation [GO:0030855]; nucleoside metabolic process [GO:0009116]; positive regulation of cell growth [GO:0030307]; purine nucleotide catabolic process [GO:0006195]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	deoxyribonucleoside 5'-monophosphate N-glycosidase activity [GO:0070694]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; deoxyribonucleoside 5'-monophosphate N-glycosidase activity [GO:0070694]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; deoxyribonucleoside monophosphate catabolic process [GO:0009159]; epithelial cell differentiation [GO:0030855]; nucleoside metabolic process [GO:0009116]; positive regulation of cell growth [GO:0030307]; purine nucleotide catabolic process [GO:0006195]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03036, ECO:0000269|PubMed:18726892}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03036}.
O43602	reviewed	DCX_HUMAN	Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X)	DCX DBCN LISX	Homo sapiens (Human)	365	FUNCTION: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. {ECO:0000269|PubMed:22359282}.		axoneme assembly [GO:0035082]; central nervous system development [GO:0007417]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; retina development in camera-type eye [GO:0060041]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]	microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; axoneme assembly [GO:0035082]; central nervous system development [GO:0007417]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; retina development in camera-type eye [GO:0060041]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9ESI7}. Note=Localizes at neurite tips. {ECO:0000250|UniProtKB:Q9ESI7}.
O43603	reviewed	GALR2_HUMAN	Galanin receptor type 2 (GAL2-R) (GALR-2)	GALR2 GALNR2	Homo sapiens (Human)	387	FUNCTION: Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). {ECO:0000269|PubMed:24517231, ECO:0000269|PubMed:25691535, ECO:0000269|PubMed:9480833, ECO:0000269|PubMed:9685625, ECO:0000269|PubMed:9832121, ECO:0000269|PubMed:9880084}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; feeding behavior [GO:0007631]; galanin-activated signaling pathway [GO:0090663]; inositol phosphate metabolic process [GO:0043647]; learning or memory [GO:0007611]; muscle contraction [GO:0006936]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; phosphatidylinositol metabolic process [GO:0046488]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of large conductance calcium-activated potassium channel activity [GO:1902608]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cilium [GO:0005929]; membrane [GO:0016020]; plasma membrane [GO:0005886]	galanin receptor activity [GO:0004966]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]	cilium [GO:0005929]; membrane [GO:0016020]; plasma membrane [GO:0005886]; galanin receptor activity [GO:0004966]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; feeding behavior [GO:0007631]; galanin-activated signaling pathway [GO:0090663]; inositol phosphate metabolic process [GO:0043647]; learning or memory [GO:0007611]; muscle contraction [GO:0006936]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; phosphatidylinositol metabolic process [GO:0046488]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of large conductance calcium-activated potassium channel activity [GO:1902608]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O43609	reviewed	SPY1_HUMAN	Protein sprouty homolog 1 (Spry-1)	SPRY1	Homo sapiens (Human)	319	FUNCTION: Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q9QXV9}.		animal organ development [GO:0048513]; bud elongation involved in lung branching [GO:0060449]; epithelial to mesenchymal transition involved in cardiac fibroblast development [GO:0060940]; ERK1 and ERK2 cascade [GO:0070371]; establishment of mitotic spindle orientation [GO:0000132]; metanephros development [GO:0001656]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; organ induction [GO:0001759]; ureteric bud development [GO:0001657]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; animal organ development [GO:0048513]; bud elongation involved in lung branching [GO:0060449]; epithelial to mesenchymal transition involved in cardiac fibroblast development [GO:0060940]; ERK1 and ERK2 cascade [GO:0070371]; establishment of mitotic spindle orientation [GO:0000132]; metanephros development [GO:0001656]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; organ induction [GO:0001759]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
O43610	reviewed	SPY3_HUMAN	Protein sprouty homolog 3 (Spry-3) (Sprouty RTK signaling antagonist 3) (Sprouty3)	SPRY3	Homo sapiens (Human)	288	FUNCTION: Inhibits neurite branching, arbor length and neurite complexity (By similarity). Inhibits EGF-mediated p42/44 ERK signaling (By similarity). Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation (PubMed:30878395). May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis (PubMed:9458049). {ECO:0000250|UniProtKB:Q3UUD2, ECO:0000269|PubMed:30878395, ECO:0000269|PubMed:9458049}.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.	animal organ development [GO:0048513]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of neuron projection arborization [GO:0150013]; negative regulation of Ras protein signal transduction [GO:0046580]; nervous system development [GO:0007399]	cytosol [GO:0005829]; membrane [GO:0016020]		cytosol [GO:0005829]; membrane [GO:0016020]; animal organ development [GO:0048513]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of neuron projection arborization [GO:0150013]; negative regulation of Ras protein signal transduction [GO:0046580]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cytoplasm.
O43612	reviewed	OREX_HUMAN	Hypocretin neuropeptide precursor (Hypocretin) (Hcrt) (Orexin precursor) (Prepro-orexin) (Preprohypocretin) [Cleaved into: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)]	HCRT OX PPORX PPOX	Homo sapiens (Human)	131	FUNCTION: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. {ECO:0000250|UniProtKB:O55232}.; FUNCTION: [Orexin-A]: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity). {ECO:0000250|UniProtKB:O55232}.; FUNCTION: [Orexin-B]: Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity). {ECO:0000250|UniProtKB:O55232}.		chemical synaptic transmission [GO:0007268]; eating behavior [GO:0042755]; excitatory postsynaptic potential [GO:0060079]; negative regulation of DNA replication [GO:0008156]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of transmission of nerve impulse [GO:0051970]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transmission of nerve impulse [GO:0051971]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of neurotransmitter secretion [GO:0046928]; response to starvation [GO:0042594]; sleep [GO:0030431]; temperature homeostasis [GO:0001659]	extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; rough endoplasmic reticulum [GO:0005791]; secretory granule [GO:0030141]; synaptic vesicle [GO:0008021]	neuropeptide hormone activity [GO:0005184]; type 1 orexin receptor binding [GO:0031771]; type 2 orexin receptor binding [GO:0031772]	extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; rough endoplasmic reticulum [GO:0005791]; secretory granule [GO:0030141]; synaptic vesicle [GO:0008021]; neuropeptide hormone activity [GO:0005184]; type 1 orexin receptor binding [GO:0031771]; type 2 orexin receptor binding [GO:0031772]; chemical synaptic transmission [GO:0007268]; eating behavior [GO:0042755]; excitatory postsynaptic potential [GO:0060079]; negative regulation of DNA replication [GO:0008156]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of transmission of nerve impulse [GO:0051970]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transmission of nerve impulse [GO:0051971]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of neurotransmitter secretion [GO:0046928]; response to starvation [GO:0042594]; sleep [GO:0030431]; temperature homeostasis [GO:0001659]	SUBCELLULAR LOCATION: Rough endoplasmic reticulum {ECO:0000250|UniProtKB:O55232}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O55232}. Synapse {ECO:0000250|UniProtKB:O55232}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250|UniProtKB:O55232}.
O43613	reviewed	OX1R_HUMAN	Orexin/Hypocretin receptor type 1 (Hypocretin receptor type 1) (Orexin receptor type 1) (Ox-1-R) (Ox1-R) (Ox1R)	HCRTR1	Homo sapiens (Human)	425	FUNCTION: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369). {ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:9491897}.	MISCELLANEOUS: The antagonists suvorexant and SB-674042 bind at the cognate neuropeptide binding site that is situated between the transmembrane helices and accessible from the extracellular side of the membrane. {ECO:0000269|PubMed:26950369}.	cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of cytosolic calcium ion concentration [GO:0051480]	plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled receptor activity [GO:0004930]; orexin receptor activity [GO:0016499]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]	plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled receptor activity [GO:0004930]; orexin receptor activity [GO:0016499]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of cytosolic calcium ion concentration [GO:0051480]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:9491897}; Multi-pass membrane protein {ECO:0000269|PubMed:26950369}.
O43614	reviewed	OX2R_HUMAN	Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2)	HCRTR2	Homo sapiens (Human)	444	FUNCTION: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369). {ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:9491897}.		cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; locomotion [GO:0040011]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]	plasma membrane [GO:0005886]; synapse [GO:0045202]	neuropeptide receptor activity [GO:0008188]; orexin receptor activity [GO:0016499]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]	plasma membrane [GO:0005886]; synapse [GO:0045202]; neuropeptide receptor activity [GO:0008188]; orexin receptor activity [GO:0016499]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; locomotion [GO:0040011]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:9491897, ECO:0000305|PubMed:25533960}; Multi-pass membrane protein {ECO:0000269|PubMed:25533960}.
O43615	reviewed	TIM44_HUMAN	Mitochondrial import inner membrane translocase subunit TIM44	TIMM44 MIMT44 TIM44	Homo sapiens (Human)	452	FUNCTION: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). {ECO:0000250|UniProtKB:O35857, ECO:0000250|UniProtKB:Q01852}.		intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]	fibrillar center [GO:0001650]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	ATP binding [GO:0005524]; protein-folding chaperone binding [GO:0051087]	fibrillar center [GO:0001650]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; ATP binding [GO:0005524]; protein-folding chaperone binding [GO:0051087]; intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:10339406}; Peripheral membrane protein {ECO:0000269|PubMed:10339406}; Matrix side {ECO:0000269|PubMed:10339406}. Mitochondrion matrix {ECO:0000269|PubMed:10339406}.
O43617	reviewed	TPPC3_HUMAN	Trafficking protein particle complex subunit 3 (BET3 homolog)	TRAPPC3 BET3 CDABP0066	Homo sapiens (Human)	180	FUNCTION: May play a role in vesicular transport from endoplasmic reticulum to Golgi.		COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	cis-Golgi network membrane [GO:0033106]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]		cis-Golgi network membrane [GO:0033106]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
O43623	reviewed	SNAI2_HUMAN	Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2)	SNAI2 SLUG SLUGH	Homo sapiens (Human)	268	FUNCTION: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. {ECO:0000250, ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:11912130, ECO:0000269|PubMed:15734731, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}.		aortic valve morphogenesis [GO:0003180]; cartilage morphogenesis [GO:0060536]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to ionizing radiation [GO:0071479]; chromatin organization [GO:0006325]; desmosome disassembly [GO:0035921]; endothelial cell migration [GO:0043542]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; epithelium development [GO:0060429]; hematopoietic stem cell proliferation [GO:0071425]; myeloid cell apoptotic process [GO:0033028]; negative regulation of anoikis [GO:2000811]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of hematopoietic stem cell proliferation [GO:1902034]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D biosynthetic process [GO:0010957]; negative regulation of vitamin D receptor signaling pathway [GO:0070563]; neural crest cell development [GO:0014032]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; osteoblast differentiation [GO:0001649]; pigmentation [GO:0043473]; positive regulation of cell migration [GO:0030335]; positive regulation of fat cell differentiation [GO:0045600]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of branching involved in salivary gland morphogenesis [GO:0060693]; regulation of chemokine production [GO:0032642]; regulation of DNA-templated transcription [GO:0006355]; regulation of osteoblast differentiation [GO:0045667]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; white fat cell differentiation [GO:0050872]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; aortic valve morphogenesis [GO:0003180]; cartilage morphogenesis [GO:0060536]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to ionizing radiation [GO:0071479]; chromatin organization [GO:0006325]; desmosome disassembly [GO:0035921]; endothelial cell migration [GO:0043542]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; epithelium development [GO:0060429]; hematopoietic stem cell proliferation [GO:0071425]; myeloid cell apoptotic process [GO:0033028]; negative regulation of anoikis [GO:2000811]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of hematopoietic stem cell proliferation [GO:1902034]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D biosynthetic process [GO:0010957]; negative regulation of vitamin D receptor signaling pathway [GO:0070563]; neural crest cell development [GO:0014032]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; osteoblast differentiation [GO:0001649]; pigmentation [GO:0043473]; positive regulation of cell migration [GO:0030335]; positive regulation of fat cell differentiation [GO:0045600]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of branching involved in salivary gland morphogenesis [GO:0060693]; regulation of chemokine production [GO:0032642]; regulation of DNA-templated transcription [GO:0006355]; regulation of osteoblast differentiation [GO:0045667]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25893292}. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.
O43633	reviewed	CHM2A_HUMAN	Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1)	CHMP2A BC2 CHMP2	Homo sapiens (Human)	222	FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. {ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692, ECO:0000305}.; FUNCTION: (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844}.	MISCELLANEOUS: Its overexpression strongly inhibits HIV-1 release.	autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; membrane invagination [GO:0010324]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of centriole elongation [GO:1903723]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of exosomal secretion [GO:1903543]; protein homooligomerization [GO:0051260]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]	phosphatidylcholine binding [GO:0031210]; protein domain specific binding [GO:0019904]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]; phosphatidylcholine binding [GO:0031210]; protein domain specific binding [GO:0019904]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; membrane invagination [GO:0010324]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of centriole elongation [GO:1903723]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of exosomal secretion [GO:1903543]; protein homooligomerization [GO:0051260]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Peripheral membrane protein {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Cytoplasmic side {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}. Nucleus envelope {ECO:0000269|PubMed:28242692}. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body. Localizes to the reforming nuclear envelope on chromatin disks during late anaphase (PubMed:28242692). {ECO:0000269|PubMed:28242692}.
O43639	reviewed	NCK2_HUMAN	Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)	NCK2 GRB4	Homo sapiens (Human)	380	FUNCTION: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242}.		actin filament organization [GO:0007015]; cell migration [GO:0016477]; dendritic spine development [GO:0060996]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; immunological synapse formation [GO:0001771]; lamellipodium assembly [GO:0030032]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990441]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; T cell activation [GO:0042110]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; postsynaptic density [GO:0014069]; vesicle membrane [GO:0012506]	cytoskeletal anchor activity [GO:0008093]; phosphotyrosine residue binding [GO:0001784]; protein-containing complex binding [GO:0044877]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; postsynaptic density [GO:0014069]; vesicle membrane [GO:0012506]; cytoskeletal anchor activity [GO:0008093]; phosphotyrosine residue binding [GO:0001784]; protein-containing complex binding [GO:0044877]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; dendritic spine development [GO:0060996]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; immunological synapse formation [GO:0001771]; lamellipodium assembly [GO:0030032]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990441]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16835242}. Endoplasmic reticulum {ECO:0000269|PubMed:16835242}.
O43653	reviewed	PSCA_HUMAN	Prostate stem cell antigen	PSCA UNQ206/PRO232	Homo sapiens (Human)	114	FUNCTION: May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. {ECO:0000269|PubMed:18488030}.; FUNCTION: May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. {ECO:0000305|PubMed:25680266}.		negative regulation of ERK1 and ERK2 cascade [GO:0070373]; regulation of neurotransmitter receptor activity [GO:0099601]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	acetylcholine receptor binding [GO:0033130]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; acetylcholine receptor binding [GO:0033130]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; regulation of neurotransmitter receptor activity [GO:0099601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9465086}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:9465086}.
O43660	reviewed	PLRG1_HUMAN	Pleiotropic regulator 1	PLRG1	Homo sapiens (Human)	514	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:33509932}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site. {ECO:0000305}.	mRNA splicing, via spliceosome [GO:0000398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein localization to nucleus [GO:0034504]	catalytic step 2 spliceosome [GO:0071013]; fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]		catalytic step 2 spliceosome [GO:0071013]; fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein localization to nucleus [GO:0034504]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. Nucleus speckle {ECO:0000269|PubMed:11544257}.
O43663	reviewed	PRC1_HUMAN	Protein regulator of cytokinesis 1	PRC1	Homo sapiens (Human)	620	FUNCTION: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}.		cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle elongation [GO:0000022]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cell population proliferation [GO:0008284]; regulation of cytokinesis [GO:0032465]	chromosome [GO:0005694]; contractile ring [GO:0070938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]	identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]	chromosome [GO:0005694]; contractile ring [GO:0070938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle elongation [GO:0000022]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cell population proliferation [GO:0008284]; regulation of cytokinesis [GO:0032465]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17409436}. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105}. Midbody {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:17409436}. Chromosome {ECO:0000269|PubMed:15297875}. Note=Colocalized with KIF20B in the nucleus of bladder carcinoma cells at the interphase. Colocalized with KIF20B in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis. Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase (PubMed:15297875, PubMed:15625105). {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:17409436}.
O43665	reviewed	RGS10_HUMAN	Regulator of G-protein signaling 10 (RGS10)	RGS10	Homo sapiens (Human)	181	FUNCTION: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196). {ECO:0000269|PubMed:10608901, ECO:0000269|PubMed:11443111, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:8774883, ECO:0000269|PubMed:9353196}.		G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:11443111}. Nucleus {ECO:0000269|PubMed:11443111}. Note=Forskolin treatment promotes phosphorylation and translocation to the nucleus. {ECO:0000269|PubMed:11443111}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10791963}.
O43670	reviewed	ZN207_HUMAN	BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207)	ZNF207 BUGZ	Homo sapiens (Human)	478	FUNCTION: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187, ECO:0000269|PubMed:26388440}.		attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein stabilization [GO:0050821]; regulation of chromosome segregation [GO:0051983]	cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule [GO:0005874]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle matrix [GO:1990047]	DNA binding [GO:0003677]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule [GO:0005874]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle matrix [GO:1990047]; DNA binding [GO:0003677]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein stabilization [GO:0050821]; regulation of chromosome segregation [GO:0051983]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26388440}. Note=Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding. {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187}.
O43674	reviewed	NDUB5_HUMAN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)	NDUFB5	Homo sapiens (Human)	189	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
O43676	reviewed	NDUB3_HUMAN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit)	NDUFB3	Homo sapiens (Human)	98	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
O43678	reviewed	NDUA2_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit)	NDUFA2	Homo sapiens (Human)	99	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; blastocyst hatching [GO:0001835]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; blastocyst hatching [GO:0001835]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
O43679	reviewed	LDB2_HUMAN	LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1)	LDB2 CLIM1	Homo sapiens (Human)	373	FUNCTION: Transcription cofactor. Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. {ECO:0000250|UniProtKB:O55203}.	MISCELLANEOUS: [Isoform 2]: Lacks LIM-binding domain. {ECO:0000305}.	cellular component biogenesis [GO:0044085]; epithelial structure maintenance [GO:0010669]; hair follicle development [GO:0001942]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of cellular component biogenesis [GO:0044089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell migration [GO:0030334]; regulation of kinase activity [GO:0043549]; somatic stem cell population maintenance [GO:0035019]	cell leading edge [GO:0031252]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]	enzyme binding [GO:0019899]; LIM domain binding [GO:0030274]; transcription coregulator activity [GO:0003712]	cell leading edge [GO:0031252]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]; enzyme binding [GO:0019899]; LIM domain binding [GO:0030274]; transcription coregulator activity [GO:0003712]; cellular component biogenesis [GO:0044085]; epithelial structure maintenance [GO:0010669]; hair follicle development [GO:0001942]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of cellular component biogenesis [GO:0044089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell migration [GO:0030334]; regulation of kinase activity [GO:0043549]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9853615}.
O43680	reviewed	TCF21_HUMAN	Transcription factor 21 (TCF-21) (Capsulin) (Class A basic helix-loop-helix protein 23) (bHLHa23) (Epicardin) (Podocyte-expressed 1) (Pod-1)	TCF21 BHLHA23 POD1	Homo sapiens (Human)	179	FUNCTION: Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.		branching involved in ureteric bud morphogenesis [GO:0001658]; branchiomeric skeletal muscle development [GO:0014707]; bronchiole development [GO:0060435]; developmental process [GO:0032502]; diaphragm development [GO:0060539]; embryonic digestive tract morphogenesis [GO:0048557]; epithelial cell differentiation [GO:0030855]; gland development [GO:0048732]; glomerulus development [GO:0032835]; kidney development [GO:0001822]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; lung vasculature development [GO:0060426]; metanephric glomerular capillary formation [GO:0072277]; metanephric mesenchymal cell differentiation [GO:0072162]; morphogenesis of a branching structure [GO:0001763]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; reproductive structure development [GO:0048608]; respiratory system development [GO:0060541]; roof of mouth development [GO:0060021]; Sertoli cell differentiation [GO:0060008]; sex determination [GO:0007530]; spleen development [GO:0048536]; ureteric bud development [GO:0001657]; vasculature development [GO:0001944]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; nuclear androgen receptor binding [GO:0050681]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; nuclear androgen receptor binding [GO:0050681]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; branching involved in ureteric bud morphogenesis [GO:0001658]; branchiomeric skeletal muscle development [GO:0014707]; bronchiole development [GO:0060435]; developmental process [GO:0032502]; diaphragm development [GO:0060539]; embryonic digestive tract morphogenesis [GO:0048557]; epithelial cell differentiation [GO:0030855]; gland development [GO:0048732]; glomerulus development [GO:0032835]; kidney development [GO:0001822]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; lung vasculature development [GO:0060426]; metanephric glomerular capillary formation [GO:0072277]; metanephric mesenchymal cell differentiation [GO:0072162]; morphogenesis of a branching structure [GO:0001763]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; reproductive structure development [GO:0048608]; respiratory system development [GO:0060541]; roof of mouth development [GO:0060021]; Sertoli cell differentiation [GO:0060008]; sex determination [GO:0007530]; spleen development [GO:0048536]; ureteric bud development [GO:0001657]; vasculature development [GO:0001944]	SUBCELLULAR LOCATION: Nucleus.
O43681	reviewed	GET3_HUMAN	ATPase GET3 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Guided entry of tail-anchored proteins factor 3, ATPase) (Transmembrane domain recognition complex 40 kDa ATPase subunit) (hARSA-I) (hASNA-I)	GET3 ARSA ASNA1 TRC40	Homo sapiens (Human)	348	FUNCTION: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. {ECO:0000255|HAMAP-Rule:MF_03112, ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:18477612, ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:31461301}.		post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein insertion into ER membrane [GO:0045048]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; GET complex [GO:0043529]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	arsenite transmembrane transporter activity [GO:0015105]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; membrane insertase activity [GO:0032977]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; GET complex [GO:0043529]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; arsenite transmembrane transporter activity [GO:0015105]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; membrane insertase activity [GO:0032977]; metal ion binding [GO:0046872]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein insertion into ER membrane [GO:0045048]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:9736449}. Endoplasmic reticulum {ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:31461301}. Nucleus, nucleolus {ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:9736449}.
O43683	reviewed	BUB1_HUMAN	Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A)	BUB1 BUB1L	Homo sapiens (Human)	1085	FUNCTION: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}.		apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; mitotic spindle assembly checkpoint signaling [GO:0007094]; phosphorylation [GO:0016310]; positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric [GO:2000720]; regulation of chromosome segregation [GO:0051983]; regulation of sister chromatid cohesion [GO:0007063]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]	ATP binding [GO:0005524]; histone H2A kinase activity [GO:0140995]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; ATP binding [GO:0005524]; histone H2A kinase activity [GO:0140995]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; mitotic spindle assembly checkpoint signaling [GO:0007094]; phosphorylation [GO:0016310]; positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric [GO:2000720]; regulation of chromosome segregation [GO:0051983]; regulation of sister chromatid cohesion [GO:0007063]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Nuclear in interphase cells. Accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase. AURKB, KNL1 and INCENP are required for kinetochore localization (By similarity). {ECO:0000250}.
O43684	reviewed	BUB3_HUMAN	Mitotic checkpoint protein BUB3	BUB3	Homo sapiens (Human)	328	FUNCTION: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:18199686}.		attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; meiotic cell cycle [GO:0051321]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]	bub1-bub3 complex [GO:1990298]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; nucleoplasm [GO:0005654]	ubiquitin binding [GO:0043130]	bub1-bub3 complex [GO:1990298]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; nucleoplasm [GO:0005654]; ubiquitin binding [GO:0043130]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; meiotic cell cycle [GO:0051321]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. {ECO:0000250}.
O43687	reviewed	AKA7A_HUMAN	A-kinase anchor protein 7 isoforms alpha and beta (AKAP-7 isoforms alpha and beta) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoforms alpha/beta) (PRKA7 isoforms alpha/beta)	AKAP7 AKAP15 AKAP18	Homo sapiens (Human)	104	FUNCTION: Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. {ECO:0000269|PubMed:10613906, ECO:0000269|PubMed:17244820, ECO:0000269|PubMed:9545239}.		action potential [GO:0001508]; cellular response to cAMP [GO:0071320]; intracellular signal transduction [GO:0035556]; monoatomic ion transport [GO:0006811]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of potassium ion transmembrane transport [GO:1901381]; protein localization [GO:0008104]; regulation of membrane repolarization [GO:0060306]	apical plasma membrane [GO:0016324]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	protein kinase A binding [GO:0051018]	apical plasma membrane [GO:0016324]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; protein kinase A binding [GO:0051018]; action potential [GO:0001508]; cellular response to cAMP [GO:0071320]; intracellular signal transduction [GO:0035556]; monoatomic ion transport [GO:0006811]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of potassium ion transmembrane transport [GO:1901381]; protein localization [GO:0008104]; regulation of membrane repolarization [GO:0060306]	SUBCELLULAR LOCATION: [Isoform Alpha]: Lateral cell membrane; Lipid-anchor. Note=Targeted predominantly to the lateral membrane.; SUBCELLULAR LOCATION: [Isoform Beta]: Apical cell membrane; Lipid-anchor. Note=Targeted predominantly to the apical membrane.
O43688	reviewed	PLPP2_HUMAN	Phospholipid phosphatase 2 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c)	PLPP2 LPP2 PPAP2C	Homo sapiens (Human)	288	FUNCTION: Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9705349, PubMed:9607309, PubMed:16467304). Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly (PubMed:16467304). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (Probable). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity). {ECO:0000250|UniProtKB:Q8K593, ECO:0000269|PubMed:16467304, ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349, ECO:0000305|PubMed:16467304}.		ceramide metabolic process [GO:0006672]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148]; sphingosine metabolic process [GO:0006670]	caveola [GO:0005901]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ceramide-1-phosphate phosphatase activity [GO:0106235]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392]	caveola [GO:0005901]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ceramide-1-phosphate phosphatase activity [GO:0106235]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392]; ceramide metabolic process [GO:0006672]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148]; sphingosine metabolic process [GO:0006670]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:16467304, ECO:0000269|PubMed:9705349}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:16467304, ECO:0000269|PubMed:9705349}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:16467304}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16467304}; Multi-pass membrane protein {ECO:0000255}.
O43699	reviewed	SIGL6_HUMAN	Sialic acid-binding Ig-like lectin 6 (Siglec-6) (CD33 antigen-like 1) (CDw327) (Obesity-binding protein 1) (OB-BP1) (CD antigen CD327)	SIGLEC6 CD33L CD33L1 OBBP1	Homo sapiens (Human)	453	FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.	MISCELLANEOUS: [Isoform 2]: Should not be confused with SIGLEC5 which has been called CD33L2. {ECO:0000305}.	cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]	cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]	cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
O43704	reviewed	ST1B1_HUMAN	Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase)	SULT1B1 ST1B2 SULT1B2	Homo sapiens (Human)	296	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440). {ECO:0000269|PubMed:28084139, ECO:0000269|PubMed:35165440, ECO:0000269|PubMed:9443824, ECO:0000269|PubMed:9463486}.		3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9443824, ECO:0000269|PubMed:9463486}.
O43707	reviewed	ACTN4_HUMAN	Alpha-actinin-4 (Non-muscle alpha-actinin 4)	ACTN4	Homo sapiens (Human)	911	FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}.	MISCELLANEOUS: [Isoform ACTN4ISO]: Does not colocalize with actin cytoskeleton structures. {ECO:0000269|PubMed:22567897}.	actin cytoskeleton organization [GO:0030036]; muscle cell development [GO:0055001]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of cell migration [GO:0030335]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of sodium:proton antiporter activity [GO:0032417]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; regulation of apoptotic process [GO:0042981]; retinoic acid receptor signaling pathway [GO:0048384]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; protein-containing complex [GO:0032991]; pseudopodium [GO:0031143]; ribonucleoprotein complex [GO:1990904]; Z disc [GO:0030018]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; chromatin DNA binding [GO:0031490]; integrin binding [GO:0005178]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nucleoside binding [GO:0001882]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713]; transmembrane transporter binding [GO:0044325]	actin cytoskeleton [GO:0015629]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; protein-containing complex [GO:0032991]; pseudopodium [GO:0031143]; ribonucleoprotein complex [GO:1990904]; Z disc [GO:0030018]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; chromatin DNA binding [GO:0031490]; integrin binding [GO:0005178]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nucleoside binding [GO:0001882]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713]; transmembrane transporter binding [GO:0044325]; actin cytoskeleton organization [GO:0030036]; muscle cell development [GO:0055001]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of cell migration [GO:0030335]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of sodium:proton antiporter activity [GO:0032417]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; regulation of apoptotic process [GO:0042981]; retinoic acid receptor signaling pathway [GO:0048384]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vesicle transport along actin filament [GO:0030050]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:9508771}. Cytoplasm {ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:9508771}. Cell junction {ECO:0000250|UniProtKB:P57780}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:9508771}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P57780}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity). Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC-2, and bladder cancer KU-7). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:9508771}.
O43708	reviewed	MAAI_HUMAN	Maleylacetoacetate isomerase (MAAI) (EC 5.2.1.2) (GSTZ1-1) (Glutathione S-transferase zeta 1) (EC 2.5.1.18)	GSTZ1 MAAI	Homo sapiens (Human)	216	FUNCTION: Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. {ECO:0000269|PubMed:10739172}.		glutathione metabolic process [GO:0006749]; L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; maleylacetoacetate isomerase activity [GO:0016034]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; maleylacetoacetate isomerase activity [GO:0016034]; protein homodimerization activity [GO:0042803]; glutathione metabolic process [GO:0006749]; L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O43709	reviewed	BUD23_HUMAN	Probable 18S rRNA (guanine-N(7))-methyltransferase (EC 2.1.1.-) (Bud site selection protein 23 homolog) (Metastasis-related methyltransferase 1) (Williams-Beuren syndrome chromosomal region 22 protein) (rRNA methyltransferase and ribosome maturation factor)	BUD23 MERM1 WBSCR22 HUSSY-03 PP3381	Homo sapiens (Human)	281	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492). {ECO:0000250, ECO:0000269|PubMed:24086612, ECO:0000269|PubMed:24488492, ECO:0000269|PubMed:25851604}.		chromatin organization [GO:0006325]; positive regulation of rRNA processing [GO:2000234]; rRNA (guanine-N7)-methylation [GO:0070476]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	methyltransferase activity [GO:0008168]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; rRNA (guanine) methyltransferase activity [GO:0016435]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; methyltransferase activity [GO:0008168]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; rRNA (guanine) methyltransferase activity [GO:0016435]; chromatin organization [GO:0006325]; positive regulation of rRNA processing [GO:2000234]; rRNA (guanine-N7)-methylation [GO:0070476]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24086612, ECO:0000269|PubMed:24488492, ECO:0000269|PubMed:34948388}. Nucleus, nucleoplasm {ECO:0000269|PubMed:25851604}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:25851604}. Cytoplasm {ECO:0000269|PubMed:24488492}. Note=Localized diffusely throughout the nucleus and the cytoplasm (PubMed:24488492). Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604). Localization is not affected by glucocorticoid treatment (PubMed:24488492). {ECO:0000269|PubMed:24488492, ECO:0000269|PubMed:25851604}.
O43711	reviewed	TLX3_HUMAN	T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2)	TLX3 HOX11L2	Homo sapiens (Human)	291			animal organ development [GO:0048513]; central nervous system development [GO:0007417]; GABAergic neuron differentiation [GO:0097154]; negative regulation of neuron differentiation [GO:0045665]; neuron fate specification [GO:0048665]; neuron migration [GO:0001764]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory gaseous exchange by respiratory system [GO:0007585]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ development [GO:0048513]; central nervous system development [GO:0007417]; GABAergic neuron differentiation [GO:0097154]; negative regulation of neuron differentiation [GO:0045665]; neuron fate specification [GO:0048665]; neuron migration [GO:0001764]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O43715	reviewed	TRIA1_HUMAN	TP53-regulated inhibitor of apoptosis 1 (Protein 15E1.1) (WF-1) (p53-inducible cell-survival factor) (p53CSV)	TRIAP1 15E1.1 HSPC132	Homo sapiens (Human)	76	FUNCTION: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003). {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759, ECO:0000269|PubMed:26071602}.		apoptotic process [GO:0006915]; cellular response to UV [GO:0034644]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; intermembrane lipid transfer [GO:0120009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; phospholipid translocation [GO:0045332]; phospholipid transport [GO:0015914]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of membrane lipid distribution [GO:0097035]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	p53 binding [GO:0002039]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; p53 binding [GO:0002039]; apoptotic process [GO:0006915]; cellular response to UV [GO:0034644]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; intermembrane lipid transfer [GO:0120009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; phospholipid translocation [GO:0045332]; phospholipid transport [GO:0015914]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of membrane lipid distribution [GO:0097035]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759}. Mitochondrion intermembrane space {ECO:0000269|PubMed:23931759}.
O43716	reviewed	GATC_HUMAN	Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (Glu-AdT subunit C) (EC 6.3.5.-) (Protein 15E1.2)	GATC 15E1.2	Homo sapiens (Human)	136	FUNCTION: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03149, ECO:0000269|PubMed:19805282}.	MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted. {ECO:0000255|HAMAP-Rule:MF_03149}.	glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543]; regulation of translational fidelity [GO:0006450]	glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567]	glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567]; glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543]; regulation of translational fidelity [GO:0006450]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03149, ECO:0000269|PubMed:19805282}.
O43719	reviewed	HTSF1_HUMAN	HIV Tat-specific factor 1 (Tat-SF1)	HTATSF1	Homo sapiens (Human)	755	FUNCTION: Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}.		mRNA splicing, via spliceosome [GO:0000398]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of transcription by RNA polymerase II [GO:0006357]; U2-type prespliceosome assembly [GO:1903241]; viral genome replication [GO:0019079]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type spliceosomal complex [GO:0005684]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type spliceosomal complex [GO:0005684]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of transcription by RNA polymerase II [GO:0006357]; U2-type prespliceosome assembly [GO:1903241]; viral genome replication [GO:0019079]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15485897, ECO:0000269|PubMed:8849451}.
O43731	reviewed	ERD23_HUMAN	ER lumen protein-retaining receptor 3 (KDEL endoplasmic reticulum protein retention receptor 3) (KDEL receptor 3)	KDELR3 ERD23	Homo sapiens (Human)	214	FUNCTION: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. {ECO:0000269|PubMed:18086916}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]	ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046]	cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]; ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18086916}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Golgi apparatus membrane {ECO:0000269|PubMed:18086916}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:18086916}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. {ECO:0000305|PubMed:18086916}.
O43734	reviewed	CIKS_HUMAN	E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)	TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6	Homo sapiens (Human)	574	FUNCTION: E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). {ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:33723527}.		B cell affinity maturation [GO:0002344]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; CD40 signaling pathway [GO:0023035]; eosinophil homeostasis [GO:1990959]; eosinophil mediated immunity [GO:0002447]; establishment of T cell polarity [GO:0001768]; heart development [GO:0007507]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; intracellular signal transduction [GO:0035556]; kidney development [GO:0001822]; leukocyte activation involved in inflammatory response [GO:0002269]; lymph node development [GO:0048535]; mRNA stabilization [GO:0048255]; mucus secretion [GO:0070254]; neutrophil activation [GO:0042119]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of defense response to virus by host [GO:0002230]; protein import into nucleus [GO:0006606]; protein K63-linked ubiquitination [GO:0070534]; protein localization to P-body [GO:0110012]; response to xenobiotic stimulus [GO:0009410]; signal transduction involved in regulation of gene expression [GO:0023019]; skin development [GO:0043588]; spleen development [GO:0048536]; T cell differentiation [GO:0030217]; T-helper 17 type immune response [GO:0072538]; transitional two stage B cell differentiation [GO:0002334]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type 2 immune response [GO:0042092]	cytoplasmic vesicle [GO:0031410]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nucleus [GO:0005634]	signaling receptor binding [GO:0005102]; ubiquitin protein ligase activity [GO:0061630]	cytoplasmic vesicle [GO:0031410]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nucleus [GO:0005634]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase activity [GO:0061630]; B cell affinity maturation [GO:0002344]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; CD40 signaling pathway [GO:0023035]; eosinophil homeostasis [GO:1990959]; eosinophil mediated immunity [GO:0002447]; establishment of T cell polarity [GO:0001768]; heart development [GO:0007507]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; intracellular signal transduction [GO:0035556]; kidney development [GO:0001822]; leukocyte activation involved in inflammatory response [GO:0002269]; lymph node development [GO:0048535]; mRNA stabilization [GO:0048255]; mucus secretion [GO:0070254]; neutrophil activation [GO:0042119]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of defense response to virus by host [GO:0002230]; protein import into nucleus [GO:0006606]; protein K63-linked ubiquitination [GO:0070534]; protein localization to P-body [GO:0110012]; response to xenobiotic stimulus [GO:0009410]; signal transduction involved in regulation of gene expression [GO:0023019]; skin development [GO:0043588]; spleen development [GO:0048536]; T cell differentiation [GO:0030217]; T-helper 17 type immune response [GO:0072538]; transitional two stage B cell differentiation [GO:0002334]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type 2 immune response [GO:0042092]	
O43739	reviewed	CYH3_HUMAN	Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3)	CYTH3 ARNO3 GRP1 PSCD3	Homo sapiens (Human)	400	FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity). {ECO:0000250|UniProtKB:O08967, ECO:0000269|PubMed:23940353, ECO:0000269|PubMed:9707577}.		establishment of epithelial cell polarity [GO:0090162]; Golgi vesicle transport [GO:0048193]; positive regulation of cell adhesion [GO:0045785]; regulation of ARF protein signal transduction [GO:0032012]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; establishment of epithelial cell polarity [GO:0090162]; Golgi vesicle transport [GO:0048193]; positive regulation of cell adhesion [GO:0045785]; regulation of ARF protein signal transduction [GO:0032012]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane {ECO:0000250|UniProtKB:O08967}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08967}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O08967}. Cell junction, tight junction {ECO:0000250|UniProtKB:O08967}. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000250|UniProtKB:O08967}.
O43741	reviewed	AAKB2_HUMAN	5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2)	PRKAB2	Homo sapiens (Human)	272	FUNCTION: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).		cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; positive regulation of cold-induced thermogenesis [GO:0120162]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]	protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; positive regulation of cold-induced thermogenesis [GO:0120162]; signal transduction [GO:0007165]	
O43745	reviewed	CHP2_HUMAN	Calcineurin B homologous protein 2 (Hepatocellular carcinoma-associated antigen 520)	CHP2 HCA520	Homo sapiens (Human)	196	FUNCTION: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. {ECO:0000269|PubMed:12226101, ECO:0000269|PubMed:18815128}.		cellular response to calcium ion [GO:0071277]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatase activity [GO:0010922]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cellular response to calcium ion [GO:0071277]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatase activity [GO:0010922]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21392185}. Cytoplasm {ECO:0000269|PubMed:21392185}. Cell membrane {ECO:0000269|PubMed:21392185}. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. {ECO:0000250}.
O43747	reviewed	AP1G1_HUMAN	AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1)	AP1G1 ADTG CLAPG1	Homo sapiens (Human)	822	FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000269|PubMed:34102099}.		basolateral protein secretion [GO:0110010]; endosome to melanosome transport [GO:0035646]; Golgi to lysosome transport [GO:0090160]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192]	AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588]	clathrin adaptor activity [GO:0035615]; collagen binding [GO:0005518]; GTP-dependent protein binding [GO:0030742]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267]	AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588]; clathrin adaptor activity [GO:0035615]; collagen binding [GO:0005518]; GTP-dependent protein binding [GO:0030742]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267]; basolateral protein secretion [GO:0110010]; endosome to melanosome transport [GO:0035646]; Golgi to lysosome transport [GO:0090160]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:12773381}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:12773381}; Peripheral membrane protein {ECO:0000269|PubMed:12773381}; Cytoplasmic side {ECO:0000269|PubMed:12773381}. Cytoplasm {ECO:0000269|PubMed:15758025}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15758025, ECO:0000269|PubMed:34102099}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:15758025}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:34102099}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (PubMed:12773381). Co-localizes with AFTPH/aftiphilin in the cytoplasm (PubMed:15758025). {ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:15758025}.
O43749	reviewed	OR1F1_HUMAN	Olfactory receptor 1F1 (Olfactory receptor 16-35) (OR16-35) (Olfactory receptor 1F10) (Olfactory receptor 1F4) (Olfactory receptor 1F5) (Olfactory receptor 1F6) (Olfactory receptor 1F7) (Olfactory receptor 1F8) (Olfactory receptor 1F9) (Olfactory receptor OR16-4)	OR1F1 OLFMF OR1F10 OR1F4 OR1F5 OR1F6 OR1F7 OR1F8 OR1F9	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O43752	reviewed	STX6_HUMAN	Syntaxin-6	STX6	Homo sapiens (Human)	255	FUNCTION: SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. {ECO:0000250|UniProtKB:Q63635}.		endocytic recycling [GO:0032456]; Golgi vesicle transport [GO:0048193]; intracellular protein transport [GO:0006886]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; endocytic recycling [GO:0032456]; Golgi vesicle transport [GO:0048193]; intracellular protein transport [GO:0006886]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23818989}; Single-pass type IV membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q63635}; Single-pass type IV membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q63635}; Single-pass type IV membrane protein {ECO:0000255}.
O43759	reviewed	SNG1_HUMAN	Synaptogyrin-1	SYNGR1	Homo sapiens (Human)	233	FUNCTION: May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:O55100, ECO:0000250|UniProtKB:Q62876}.		cellular response to leukemia inhibitory factor [GO:1990830]; protein targeting [GO:0006605]; regulated exocytosis [GO:0045055]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic vesicle membrane organization [GO:0048499]	azurophil granule membrane [GO:0035577]; melanosome [GO:0042470]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]		azurophil granule membrane [GO:0035577]; melanosome [GO:0042470]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; cellular response to leukemia inhibitory factor [GO:1990830]; protein targeting [GO:0006605]; regulated exocytosis [GO:0045055]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic vesicle membrane organization [GO:0048499]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q62876}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q62876}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.
O43760	reviewed	SNG2_HUMAN	Synaptogyrin-2 (Cellugyrin)	SYNGR2 UNQ352/PRO615	Homo sapiens (Human)	224	FUNCTION: May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. {ECO:0000250|UniProtKB:O54980}.; FUNCTION: (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication. {ECO:0000269|PubMed:27226560}.		regulated exocytosis [GO:0045055]; synaptic vesicle membrane organization [GO:0048499]	extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; synaptic vesicle membrane [GO:0030672]		extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; synaptic vesicle membrane [GO:0030672]; regulated exocytosis [GO:0045055]; synaptic vesicle membrane organization [GO:0048499]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O54980}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O54980}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to cytoplasmic vesicles associated with the recycling endosomes. {ECO:0000250|UniProtKB:O54980}.; SUBCELLULAR LOCATION: Lipid droplet. Note=(Microbial infection) Upon SFTS phlebovirus infection, the protein localizes in lipid droplets and inclusion bodies. {ECO:0000269|PubMed:27226560}.
O43761	reviewed	SNG3_HUMAN	Synaptogyrin-3	SYNGR3	Homo sapiens (Human)	229	FUNCTION: May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal. {ECO:0000250|UniProtKB:Q8R191}.		positive regulation of transporter activity [GO:0032411]; regulated exocytosis [GO:0045055]; regulation of neurotransmitter uptake [GO:0051580]; substantia nigra development [GO:0021762]	membrane [GO:0016020]; neuromuscular junction [GO:0031594]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	SH2 domain binding [GO:0042169]	membrane [GO:0016020]; neuromuscular junction [GO:0031594]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; SH2 domain binding [GO:0042169]; positive regulation of transporter activity [GO:0032411]; regulated exocytosis [GO:0045055]; regulation of neurotransmitter uptake [GO:0051580]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8R191}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q8R191}. Note=Found at the neuromuscular synapses. {ECO:0000250|UniProtKB:Q8R191}.
O43763	reviewed	TLX2_HUMAN	T-cell leukemia homeobox protein 2 (Homeobox protein Hox-11L1) (Neural crest homeobox protein)	TLX2 HOX11L1 NCX	Homo sapiens (Human)	284	FUNCTION: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity). {ECO:0000250}.		animal organ development [GO:0048513]; enteric nervous system development [GO:0048484]; mesoderm formation [GO:0001707]; negative regulation of dendrite morphogenesis [GO:0050774]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ development [GO:0048513]; enteric nervous system development [GO:0048484]; mesoderm formation [GO:0001707]; negative regulation of dendrite morphogenesis [GO:0050774]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O43765	reviewed	SGTA_HUMAN	Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP)	SGTA SGT SGT1	Homo sapiens (Human)	313	FUNCTION: Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). {ECO:0000269|PubMed:18759457, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744). {ECO:0000269|PubMed:24675744}.		negative regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903070]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; TRC complex [GO:0072380]	BAT3 complex binding [GO:1904288]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein self-association [GO:0043621]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; TRC complex [GO:0072380]; BAT3 complex binding [GO:1904288]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein self-association [GO:0043621]; negative regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903070]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16580629}. Nucleus {ECO:0000269|PubMed:16580629}. Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis. {ECO:0000269|PubMed:16580629}.
O43766	reviewed	LIAS_HUMAN	Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase)	LIAS LAS HUSSY-01	Homo sapiens (Human)	372	FUNCTION: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000255|HAMAP-Rule:MF_03123}.		inflammatory response [GO:0006954]; lipoate biosynthetic process [GO:0009107]; neural tube closure [GO:0001843]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	4 iron, 4 sulfur cluster binding [GO:0051539]; lipoate synthase activity [GO:0016992]; metal ion binding [GO:0046872]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 4 iron, 4 sulfur cluster binding [GO:0051539]; lipoate synthase activity [GO:0016992]; metal ion binding [GO:0046872]; inflammatory response [GO:0006954]; lipoate biosynthetic process [GO:0009107]; neural tube closure [GO:0001843]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03123}.
O43768	reviewed	ENSA_HUMAN	Alpha-endosulfine (ARPP-19e)	ENSA	Homo sapiens (Human)	121	FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269|PubMed:9653196}.		cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; negative regulation of protein dephosphorylation [GO:0035308]; regulation of insulin secretion [GO:0050796]; response to nutrient [GO:0007584]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	ion channel inhibitor activity [GO:0008200]; phosphatase inhibitor activity [GO:0019212]; potassium channel inhibitor activity [GO:0019870]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; ion channel inhibitor activity [GO:0008200]; phosphatase inhibitor activity [GO:0019212]; potassium channel inhibitor activity [GO:0019870]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]; signaling receptor binding [GO:0005102]; cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; negative regulation of protein dephosphorylation [GO:0035308]; regulation of insulin secretion [GO:0050796]; response to nutrient [GO:0007584]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O43772	reviewed	MCAT_HUMAN	Mitochondrial carnitine/acylcarnitine carrier protein (Carnitine/acylcarnitine translocase) (CAC) (CACT) (Solute carrier family 25 member 20)	SLC25A20 CAC CACT	Homo sapiens (Human)	301	FUNCTION: Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (PubMed:12892634, PubMed:18307102) (Probable). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange) (PubMed:18307102). {ECO:0000269|PubMed:12892634, ECO:0000269|PubMed:18307102, ECO:0000305|PubMed:18307102, ECO:0000305|PubMed:20347717}.		carnitine shuttle [GO:0006853]; carnitine transmembrane transport [GO:1902603]; in utero embryonic development [GO:0001701]; mitochondrial transport [GO:0006839]	cytosol [GO:0005829]; mitochondrial envelope [GO:0005740]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	acyl carnitine transmembrane transporter activity [GO:0015227]	cytosol [GO:0005829]; mitochondrial envelope [GO:0005740]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; acyl carnitine transmembrane transporter activity [GO:0015227]; carnitine shuttle [GO:0006853]; carnitine transmembrane transport [GO:1902603]; in utero embryonic development [GO:0001701]; mitochondrial transport [GO:0006839]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
O43776	reviewed	SYNC_HUMAN	Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1)	NARS1 NARS NRS	Homo sapiens (Human)	548	FUNCTION: Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:9421509, PubMed:32738225, PubMed:32788587). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:30171954, PubMed:12235211). Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells (PubMed:32788587). {ECO:0000269|PubMed:12235211, ECO:0000269|PubMed:30171954, ECO:0000269|PubMed:32738225, ECO:0000269|PubMed:32788587, ECO:0000269|PubMed:9421509}.	MISCELLANEOUS: Autoantibodies to NARS1, are often detected in sera from patients with interstitial lung disease (ILD). {ECO:0000269|PubMed:9973509}.	asparaginyl-tRNA aminoacylation [GO:0006421]; cell migration [GO:0016477]; cerebral cortex development [GO:0021987]; tRNA aminoacylation for protein translation [GO:0006418]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; CCR3 chemokine receptor binding [GO:0031728]; nucleic acid binding [GO:0003676]; protein dimerization activity [GO:0046983]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; CCR3 chemokine receptor binding [GO:0031728]; nucleic acid binding [GO:0003676]; protein dimerization activity [GO:0046983]; asparaginyl-tRNA aminoacylation [GO:0006421]; cell migration [GO:0016477]; cerebral cortex development [GO:0021987]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:9421509}.
O43781	reviewed	DYRK3_HUMAN	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK)	DYRK3	Homo sapiens (Human)	588	FUNCTION: Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:9748265, PubMed:29634919). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (PubMed:29973724). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (PubMed:29973724). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (PubMed:23415227). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (PubMed:10779429). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). {ECO:0000269|PubMed:10779429, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:29634919, ECO:0000269|PubMed:29973724, ECO:0000269|PubMed:9748265}.		cell cycle [GO:0007049]; cell division [GO:0051301]; erythrocyte differentiation [GO:0030218]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; nuclear speck organization [GO:0035063]; organelle disassembly [GO:1903008]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; protein phosphorylation [GO:0006468]; regulation of cellular response to stress [GO:0080135]; regulation of TORC1 signaling [GO:1903432]; stress granule disassembly [GO:0035617]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; cell cycle [GO:0007049]; cell division [GO:0051301]; erythrocyte differentiation [GO:0030218]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; nuclear speck organization [GO:0035063]; organelle disassembly [GO:1903008]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; protein phosphorylation [GO:0006468]; regulation of cellular response to stress [GO:0080135]; regulation of TORC1 signaling [GO:1903432]; stress granule disassembly [GO:0035617]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10779429, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:29973724}. Cytoplasm {ECO:0000269|PubMed:29973724}. Nucleus speckle {ECO:0000269|PubMed:29973724}. Cytoplasmic granule {ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:29973724}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29973724}. Note=Associates with membraneless organelles in the cytoplasm and nucleus (PubMed:29973724). Shuttles between cytoplasm and stress granules (PubMed:20167603). Localized predominantly on distinct speckles distributed throughout the cytoplasm of the cell (PubMed:20167603). At low concentration, showns a homogeneous distribution throughout the cytoplasm and does not condense in speckles. During oxidative and osmotic stress, localizes to stress granules (PubMed:20167603). {ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:29973724}.
O43790	reviewed	KRT86_HUMAN	Keratin, type II cuticular Hb6 (Hair keratin K2.11) (Keratin-86) (K86) (Type II hair keratin Hb6) (Type-II keratin Kb26)	KRT86 KRTHB6	Homo sapiens (Human)	486		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; extracellular space [GO:0005615]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular space [GO:0005615]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
O43791	reviewed	SPOP_HUMAN	Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)	SPOP	Homo sapiens (Human)	374	FUNCTION: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (PubMed:32109420). {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832, ECO:0000269|PubMed:32109420}.	MISCELLANEOUS: Antigen recognized by serum from scleroderma patient.	localization [GO:0051179]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of proteolysis [GO:0030162]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	molecular function inhibitor activity [GO:0140678]; ubiquitin protein ligase binding [GO:0031625]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; molecular function inhibitor activity [GO:0140678]; ubiquitin protein ligase binding [GO:0031625]; localization [GO:0051179]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of proteolysis [GO:0030162]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22085717}. Nucleus speckle {ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:9414087}.
O43795	reviewed	MYO1B_HUMAN	Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa)	MYO1B	Homo sapiens (Human)	1136	FUNCTION: Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport. {ECO:0000250}.		actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; post-Golgi vesicle-mediated transport [GO:0006892]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; apical part of cell [GO:0045177]; brush border [GO:0005903]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; microvillus [GO:0005902]; myosin complex [GO:0016459]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; apical part of cell [GO:0045177]; brush border [GO:0005903]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; microvillus [GO:0005902]; myosin complex [GO:0016459]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; post-Golgi vesicle-mediated transport [GO:0006892]; vesicle transport along actin filament [GO:0030050]	
O43805	reviewed	SSNA1_HUMAN	Microtubule nucleation factor SSNA1 (Nuclear autoantigen of 14 kDa) (Sjoegren syndrome nuclear autoantigen 1)	SSNA1 NA14	Homo sapiens (Human)	119	FUNCTION: Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST (PubMed:34970964). Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules (By similarity). Plays a role in axon outgrowth and branching (PubMed:25390646). Required for cell division (PubMed:25390646). {ECO:0000250|UniProtKB:Q9XF62, ECO:0000269|PubMed:25390646, ECO:0000269|PubMed:34970964}.		axon arborization [GO:0140060]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; cell cycle [GO:0007049]; cell division [GO:0051301]; ciliary receptor clustering involved in smoothened signaling pathway [GO:0060830]; intraciliary transport [GO:0042073]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]	axon [GO:0030424]; axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; midbody [GO:0030496]; motile cilium [GO:0031514]; nucleus [GO:0005634]; supramolecular fiber [GO:0099512]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein self-association [GO:0043621]	axon [GO:0030424]; axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; midbody [GO:0030496]; motile cilium [GO:0031514]; nucleus [GO:0005634]; supramolecular fiber [GO:0099512]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein self-association [GO:0043621]; axon arborization [GO:0140060]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; cell cycle [GO:0007049]; cell division [GO:0051301]; ciliary receptor clustering involved in smoothened signaling pathway [GO:0060830]; intraciliary transport [GO:0042073]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9430706}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12640030, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:25390646}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:25390646}. Midbody {ECO:0000269|PubMed:25390646}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000269|PubMed:12640030}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:12640030}. Cell projection, axon {ECO:0000250|UniProtKB:Q9JJ94}. Note=In sperm, strongly expressed in the basal body region with weaker expression in the axoneme (PubMed:12640030). Localizes to axon branching points in neurons (By similarity). {ECO:0000250|UniProtKB:Q9JJ94, ECO:0000269|PubMed:12640030}.
O43808	reviewed	PM34_HUMAN	Peroxisomal membrane protein PMP34 (34 kDa peroxisomal membrane protein) (Solute carrier family 25 member 17)	SLC25A17 PMP34	Homo sapiens (Human)	307	FUNCTION: Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. {ECO:0000269|PubMed:22185573}.		ATP transport [GO:0015867]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; fatty acid transport [GO:0015908]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	adenine nucleotide transmembrane transporter activity [GO:0000295]; ADP transmembrane transporter activity [GO:0015217]; AMP transmembrane transporter activity [GO:0080122]; antiporter activity [GO:0015297]; ATP transmembrane transporter activity [GO:0005347]; coenzyme A transmembrane transporter activity [GO:0015228]; FAD transmembrane transporter activity [GO:0015230]; FMN transmembrane transporter activity [GO:0044610]; NAD transmembrane transporter activity [GO:0051724]; protein-folding chaperone binding [GO:0051087]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; adenine nucleotide transmembrane transporter activity [GO:0000295]; ADP transmembrane transporter activity [GO:0015217]; AMP transmembrane transporter activity [GO:0080122]; antiporter activity [GO:0015297]; ATP transmembrane transporter activity [GO:0005347]; coenzyme A transmembrane transporter activity [GO:0015228]; FAD transmembrane transporter activity [GO:0015230]; FMN transmembrane transporter activity [GO:0044610]; NAD transmembrane transporter activity [GO:0051724]; protein-folding chaperone binding [GO:0051087]; ATP transport [GO:0015867]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; fatty acid transport [GO:0015908]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14709540}. Peroxisome membrane {ECO:0000269|PubMed:11121399, ECO:0000269|PubMed:11402059, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:9874197}; Multi-pass membrane protein {ECO:0000255}.
O43809	reviewed	CPSF5_HUMAN	Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit)	NUDT21 CFIM25 CPSF25 CPSF5	Homo sapiens (Human)	227	FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:15937220, PubMed:17024186, PubMed:17098938, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:17098938, PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:17098938, PubMed:20695905, PubMed:29276085). NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7 (PubMed:29276085). Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing (PubMed:8626397, PubMed:14690600, PubMed:15169763, PubMed:17024186, PubMed:22813749, PubMed:20479262). The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA (PubMed:20479262, PubMed:21295486). Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function (By similarity). Binds to chromatin (By similarity). Binds to, but does not hydrolyze mono- and di-adenosine nucleotides (PubMed:18445629). {ECO:0000250|UniProtKB:Q9CQF3, ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:15937220, ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:17098938, ECO:0000269|PubMed:18445629, ECO:0000269|PubMed:20479262, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:22813749, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.		cell differentiation [GO:0030154]; messenger ribonucleoprotein complex assembly [GO:1990120]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; mRNA polyadenylation [GO:0006378]; mRNA processing [GO:0006397]; positive regulation of pro-B cell differentiation [GO:2000975]; positive regulation of stem cell differentiation [GO:2000738]; post-transcriptional regulation of gene expression [GO:0010608]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]	chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; cell differentiation [GO:0030154]; messenger ribonucleoprotein complex assembly [GO:1990120]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; mRNA polyadenylation [GO:0006378]; mRNA processing [GO:0006397]; positive regulation of pro-B cell differentiation [GO:2000975]; positive regulation of stem cell differentiation [GO:2000738]; post-transcriptional regulation of gene expression [GO:0010608]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:9659921}. Cytoplasm {ECO:0000269|PubMed:19864460}. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles (PubMed:15169763). {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460}.
O43813	reviewed	LANC1_HUMAN	Glutathione S-transferase LANCL1 (EC 2.5.1.18) (40 kDa erythrocyte membrane protein) (p40) (LanC-like protein 1)	LANCL1 GPR69A	Homo sapiens (Human)	399	FUNCTION: Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316). {ECO:0000250|UniProtKB:O89112, ECO:0000269|PubMed:19528316}.	MISCELLANEOUS: Was originally thought to be a G-protein coupled receptor. {ECO:0000305|PubMed:9512664}.	carbohydrate metabolic process [GO:0005975]; cellular detoxification [GO:1990748]; G protein-coupled receptor signaling pathway [GO:0007186]; peptide modification [GO:0031179]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; low-density lipoprotein particle receptor binding [GO:0050750]; SH3 domain binding [GO:0017124]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; low-density lipoprotein particle receptor binding [GO:0050750]; SH3 domain binding [GO:0017124]; zinc ion binding [GO:0008270]; carbohydrate metabolic process [GO:0005975]; cellular detoxification [GO:1990748]; G protein-coupled receptor signaling pathway [GO:0007186]; peptide modification [GO:0031179]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15811525}. Cell membrane {ECO:0000269|PubMed:10944443, ECO:0000269|PubMed:16979580}; Peripheral membrane protein {ECO:0000269|PubMed:10944443}.
O43815	reviewed	STRN_HUMAN	Striatin	STRN	Homo sapiens (Human)	780	FUNCTION: Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.		bicellular tight junction assembly [GO:0070830]; dendrite development [GO:0016358]; locomotory behavior [GO:0007626]; negative regulation of cell population proliferation [GO:0008285]; Wnt signaling pathway [GO:0016055]	bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]	armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; nuclear estrogen receptor binding [GO:0030331]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]	bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; nuclear estrogen receptor binding [GO:0030331]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; bicellular tight junction assembly [GO:0070830]; dendrite development [GO:0016358]; locomotory behavior [GO:0007626]; negative regulation of cell population proliferation [GO:0008285]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.
O43818	reviewed	U3IP2_HUMAN	U3 small nucleolar RNA-interacting protein 2 (RRP9 homolog) (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K)	RRP9 RNU3IP2 U355K	Homo sapiens (Human)	475	FUNCTION: Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA) (PubMed:26867678). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:26867678, ECO:0000269|PubMed:34516797}.		ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	box C/D RNP complex [GO:0031428]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; U3 snoRNA binding [GO:0034511]	box C/D RNP complex [GO:0031428]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; U3 snoRNA binding [GO:0034511]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:26867678, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:9418896}.
O43819	reviewed	SCO2_HUMAN	Protein SCO2 homolog, mitochondrial	SCO2	Homo sapiens (Human)	266	FUNCTION: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15229189, PubMed:17189203). Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2 (PubMed:19336478). {ECO:0000269|PubMed:15229189, ECO:0000269|PubMed:17189203, ECO:0000269|PubMed:19336478}.		eye development [GO:0001654]; in utero embryonic development [GO:0001701]; intracellular copper ion homeostasis [GO:0006878]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; muscle system process [GO:0003012]; respiratory electron transport chain [GO:0022904]; response to activity [GO:0014823]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; myofibril [GO:0030016]	copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]; protein-disulfide reductase activity [GO:0015035]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; myofibril [GO:0030016]; copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]; protein-disulfide reductase activity [GO:0015035]; eye development [GO:0001654]; in utero embryonic development [GO:0001701]; intracellular copper ion homeostasis [GO:0006878]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; muscle system process [GO:0003012]; respiratory electron transport chain [GO:0022904]; response to activity [GO:0014823]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:15229189}; Single-pass membrane protein {ECO:0000255}.
O43820	reviewed	HYAL3_HUMAN	Hyaluronidase-3 (Hyal-3) (EC 3.2.1.35) (Hyaluronoglucosaminidase-3) (Lung carcinoma protein 3) (LuCa-3)	HYAL3 LUCA3	Homo sapiens (Human)	417	FUNCTION: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. {ECO:0000250|UniProtKB:Q8VEI3}.	MISCELLANEOUS: [Isoform 2]: Enzymatically inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Enzymatically inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Enzymatically inactive. {ECO:0000305}.	carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; hyaluronan catabolic process [GO:0030214]; inflammatory response [GO:0006954]; negative regulation of ovarian follicle development [GO:2000355]; ovarian follicle atresia [GO:0001552]; penetration of zona pellucida [GO:0007341]; positive regulation of acrosomal vesicle exocytosis [GO:2000368]; response to antibiotic [GO:0046677]; response to virus [GO:0009615]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]	hyaluronoglucuronidase activity [GO:0033906]; hyalurononglucosaminidase activity [GO:0004415]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]; hyaluronoglucuronidase activity [GO:0033906]; hyalurononglucosaminidase activity [GO:0004415]; carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; hyaluronan catabolic process [GO:0030214]; inflammatory response [GO:0006954]; negative regulation of ovarian follicle development [GO:2000355]; ovarian follicle atresia [GO:0001552]; penetration of zona pellucida [GO:0007341]; positive regulation of acrosomal vesicle exocytosis [GO:2000368]; response to antibiotic [GO:0046677]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8VEI3}. Cell membrane {ECO:0000250|UniProtKB:Q8VEI3}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8VEI3}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VEI3}. Early endosome {ECO:0000250|UniProtKB:Q8VEI3}. Note=Mostly present in low-density vesicles. Low levels in higher density vesicles of late endosomes and lysosomes. Localized in punctate cytoplasmic vesicles and in perinuclear structures, but does not colocalize with LAMP1. Localized on the plasma membrane over the acrosome and on the surface of the midpiece of the sperm tail. {ECO:0000250|UniProtKB:Q8VEI3}.
O43822	reviewed	CF410_HUMAN	Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2)	CFAP410 C21orf2 LRRC76	Homo sapiens (Human)	256	FUNCTION: Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490). {ECO:0000250|UniProtKB:Q8C6G1, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:26290490}.		cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; DNA damage response [GO:0006974]; regulation of cell shape [GO:0008360]; smoothened signaling pathway [GO:0007224]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]		ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; DNA damage response [GO:0006974]; regulation of cell shape [GO:0008360]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:9325172}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:26167768, ECO:0000269|PubMed:26294103}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:27548899}. Cytoplasm {ECO:0000269|PubMed:26290490}. Note=Colocalizes with NEK1 and SPATA7 at the basal body. {ECO:0000269|PubMed:26167768}.
O43823	reviewed	AKAP8_HUMAN	A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95)	AKAP8 AKAP95	Homo sapiens (Human)	692	FUNCTION: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}.		cell cycle G2/M phase transition [GO:0044839]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to prostaglandin E stimulus [GO:0071380]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; negative regulation of tumor necrosis factor production [GO:0032720]; protein transport [GO:0015031]; signal transduction [GO:0007165]	condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; NF-kappaB binding [GO:0051059]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; NF-kappaB binding [GO:0051059]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; cell cycle G2/M phase transition [GO:0044839]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to prostaglandin E stimulus [GO:0071380]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; negative regulation of tumor necrosis factor production [GO:0032720]; protein transport [GO:0015031]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19277197, ECO:0000269|PubMed:26683827}. Nucleus matrix {ECO:0000269|PubMed:10601332}. Nucleus, nucleolus {ECO:0000269|PubMed:26683827}. Cytoplasm {ECO:0000250|UniProtKB:Q9DBR0}. Note=Associated with the nuclear matrix in interphase and redistributes mostly to chromatin at mitosis. However, mitotic chromatin localization has been questioned. Upon nuclear reassembly at the end of mitosis, is sequestered into the daughter nuclei where it re-acquires an interphase distribution. Exhibits partial localization to the nucleolus in interphase, where it colocalizes with UBTF/UBF, suggesting localization to the fibrillary center and/or to the dense fibrillary component. Colocalizes with GJA1 at the nuclear membrane specifically during cell cycle G1/S phase. {ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274}.
O43825	reviewed	B3GT2_HUMAN	Beta-1,3-galactosyltransferase 2 (Beta-1,3-GalTase 2) (Beta3Gal-T2) (Beta3GalT2) (EC 2.4.1.86) (UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2)	B3GALT2	Homo sapiens (Human)	422	FUNCTION: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues. {ECO:0000269|PubMed:9417100, ECO:0000269|PubMed:9582303}.		galactosylceramide biosynthetic process [GO:0006682]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity [GO:0047275]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity [GO:0047275]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; galactosylceramide biosynthetic process [GO:0006682]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
O43826	reviewed	G6PT1_HUMAN	Glucose-6-phosphate exchanger SLC37A4 (Glucose-5-phosphate transporter) (Glucose-6-phosphate translocase) (Solute carrier family 37 member 4) (Transformation-related gene 19 protein) (TRG-19)	SLC37A4 G6PT G6PT1 PRO0685 TRG19	Homo sapiens (Human)	429	FUNCTION: Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction (PubMed:33964207). Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels. {ECO:0000269|PubMed:10026167, ECO:0000269|PubMed:21949678, ECO:0000269|PubMed:33964207}.		carbohydrate transport [GO:0008643]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glucose-6-phosphate transport [GO:0015760]; phosphate ion transmembrane transport [GO:0035435]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	glucose 6-phosphate:inorganic phosphate antiporter activity [GO:0061513]; glucose-6-phosphate transmembrane transporter activity [GO:0015152]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; glucose 6-phosphate:inorganic phosphate antiporter activity [GO:0061513]; glucose-6-phosphate transmembrane transporter activity [GO:0015152]; carbohydrate transport [GO:0008643]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glucose-6-phosphate transport [GO:0015760]; phosphate ion transmembrane transport [GO:0035435]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21949678, ECO:0000269|PubMed:32884905, ECO:0000269|PubMed:33964207}; Multi-pass membrane protein {ECO:0000255}.
O43827	reviewed	ANGL7_HUMAN	Angiopoietin-related protein 7 (Angiopoietin-like factor) (Angiopoietin-like protein 7) (Cornea-derived transcript 6 protein)	ANGPTL7 CDT6 UNQ313/PRO356	Homo sapiens (Human)	346	FUNCTION: Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed:21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed:25622036). {ECO:0000269|PubMed:21199193, ECO:0000269|PubMed:25622036}.		negative regulation of vasculature development involved in avascular cornea development in camera-type eye [GO:1901346]; regulation of extracellular matrix organization [GO:1903053]; response to oxidative stress [GO:0006979]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	identical protein binding [GO:0042802]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; identical protein binding [GO:0042802]; negative regulation of vasculature development involved in avascular cornea development in camera-type eye [GO:1901346]; regulation of extracellular matrix organization [GO:1903053]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11682471}.
O43829	reviewed	ZBT14_HUMAN	Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5)	ZBTB14 ZFP161 ZNF478	Homo sapiens (Human)	449	FUNCTION: Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. {ECO:0000269|PubMed:17714511}.		cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart valve development [GO:0003170]; kidney development [GO:0001822]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	aggresome [GO:0016235]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	aggresome [GO:0016235]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart valve development [GO:0003170]; kidney development [GO:0001822]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15629158}. Note=Colocalizes with ZBTB21 in nucleus in HEK293 cells.
O43837	reviewed	IDH3B_HUMAN	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta)	IDH3B	Homo sapiens (Human)	385	FUNCTION: Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. {ECO:0000269|PubMed:28139779}.		isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099]	mitochondrial isocitrate dehydrogenase complex (NAD+) [GO:0005962]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	electron transfer activity [GO:0009055]; isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]	mitochondrial isocitrate dehydrogenase complex (NAD+) [GO:0005962]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; electron transfer activity [GO:0009055]; isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion.
O43847	reviewed	NRDC_HUMAN	Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase)	NRDC NRD1	Homo sapiens (Human)	1151	FUNCTION: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}.		negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of axonogenesis [GO:0050772]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of myelination [GO:0031643]; proteolysis [GO:0006508]; regulation of endopeptidase activity [GO:0052548]	cell surface [GO:0009986]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrion [GO:0005739]	epidermal growth factor binding [GO:0048408]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	cell surface [GO:0009986]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; epidermal growth factor binding [GO:0048408]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of axonogenesis [GO:0050772]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of myelination [GO:0031643]; proteolysis [GO:0006508]; regulation of endopeptidase activity [GO:0052548]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:28017472}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHG1}.
O43852	reviewed	CALU_HUMAN	Calumenin (Crocalbin) (IEF SSP 9302)	CALU	Homo sapiens (Human)	315	FUNCTION: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}.			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; sarcoplasmic reticulum lumen [GO:0033018]	calcium ion binding [GO:0005509]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; sarcoplasmic reticulum lumen [GO:0033018]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10222138}. Golgi apparatus {ECO:0000269|PubMed:10222138}. Secreted {ECO:0000305}. Melanosome {ECO:0000269|PubMed:12643545}. Sarcoplasmic reticulum lumen {ECO:0000305}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545}.
O43854	reviewed	EDIL3_HUMAN	EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1)	EDIL3 DEL1	Homo sapiens (Human)	480	FUNCTION: Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.		cell adhesion [GO:0007155]; positive regulation of cell-substrate adhesion [GO:0010811]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]	calcium ion binding [GO:0005509]; integrin binding [GO:0005178]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; positive regulation of cell-substrate adhesion [GO:0010811]	SUBCELLULAR LOCATION: Secreted.
O43861	reviewed	ATP9B_HUMAN	Probable phospholipid-transporting ATPase IIB (EC 7.6.2.1) (ATPase class II type 9B)	ATP9B ATPIIB NEO1L HUSSY-20	Homo sapiens (Human)	1147			endocytosis [GO:0006897]; phospholipid translocation [GO:0045332]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]	endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; endocytosis [GO:0006897]; phospholipid translocation [GO:0045332]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21914794}; Multi-pass membrane protein {ECO:0000269|PubMed:21914794}. Note=Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B.
O43865	reviewed	SAHH2_HUMAN	S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2)	AHCYL1 DCAL IRBIT XPVKONA	Homo sapiens (Human)	530	FUNCTION: Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed:27995898). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). {ECO:0000250|UniProtKB:B5DFN2, ECO:0000250|UniProtKB:Q80SW1, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:16793548, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:19224921, ECO:0000269|PubMed:20584908, ECO:0000269|PubMed:25237103, ECO:0000269|PubMed:27995898}.	MISCELLANEOUS: Ablation of expression in HeLa cells causes imbalanced dNTP pools and altered cell cycle progression. {ECO:0000269|PubMed:25237103}.	angiotensin-activated signaling pathway [GO:0038166]; apoptotic process [GO:0006915]; epithelial fluid transport [GO:0042045]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; mRNA polyadenylation [GO:0006378]; one-carbon metabolic process [GO:0006730]; positive regulation of sodium ion transport [GO:0010765]; protein export from nucleus [GO:0006611]; regulation of monoatomic anion transport [GO:0044070]; regulation of monoatomic ion transmembrane transporter activity [GO:0032412]; regulation of mRNA 3'-end processing [GO:0031440]; response to calcium ion [GO:0051592]; S-adenosylmethionine cycle [GO:0033353]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]	enzyme regulator activity [GO:0030234]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; enzyme regulator activity [GO:0030234]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; angiotensin-activated signaling pathway [GO:0038166]; apoptotic process [GO:0006915]; epithelial fluid transport [GO:0042045]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; mRNA polyadenylation [GO:0006378]; one-carbon metabolic process [GO:0006730]; positive regulation of sodium ion transport [GO:0010765]; protein export from nucleus [GO:0006611]; regulation of monoatomic anion transport [GO:0044070]; regulation of monoatomic ion transmembrane transporter activity [GO:0032412]; regulation of mRNA 3'-end processing [GO:0031440]; response to calcium ion [GO:0051592]; S-adenosylmethionine cycle [GO:0033353]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:27995898, ECO:0000269|PubMed:28647132}. Cytoplasm, cytosol {ECO:0000269|PubMed:27995898}. Apical cell membrane {ECO:0000250|UniProtKB:B5DFN2}; Peripheral membrane protein {ECO:0000305}. Microsome {ECO:0000250|UniProtKB:Q80SW1}. Note=Associates with membranes when phosphorylated, probably through interaction with ITPR1 (By similarity). Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:27995898). Localization to MAMs is greatly reduced under apoptotic stress conditions (PubMed:27995898). {ECO:0000250|UniProtKB:Q80SW1, ECO:0000269|PubMed:27995898}.
O43866	reviewed	CD5L_HUMAN	CD5 antigen-like (Apoptosis inhibitor expressed by macrophages) (hAIM) (CT-2) (IgM-associated peptide) (SP-alpha)	CD5L API6 UNQ203/PRO229	Homo sapiens (Human)	347	FUNCTION: Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983). {ECO:0000250|UniProtKB:Q9QWK4, ECO:0000269|PubMed:16030018, ECO:0000269|PubMed:24223991, ECO:0000269|PubMed:24295828, ECO:0000269|PubMed:24583716, ECO:0000269|PubMed:25713983}.		apoptotic process [GO:0006915]; cellular defense response [GO:0006968]; immune system process [GO:0002376]; inflammatory response [GO:0006954]; positive regulation of complement-dependent cytotoxicity [GO:1903661]; regulation of complement activation [GO:0030449]; zymogen activation [GO:0031638]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; apoptotic process [GO:0006915]; cellular defense response [GO:0006968]; immune system process [GO:0002376]; inflammatory response [GO:0006954]; positive regulation of complement-dependent cytotoxicity [GO:1903661]; regulation of complement activation [GO:0030449]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24223991, ECO:0000269|PubMed:24804991}. Cytoplasm {ECO:0000250|UniProtKB:Q9QWK4}. Note=Secreted by macrophages and circulates in the blood (PubMed:24223991, PubMed:24804991). Transported in the cytoplasm via CD36-mediated endocytosis (By similarity). {ECO:0000250|UniProtKB:Q9QWK4, ECO:0000269|PubMed:24223991, ECO:0000269|PubMed:24804991}.
O43868	reviewed	S28A2_HUMAN	Sodium/nucleoside cotransporter 2 (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Sodium/purine nucleoside co-transporter) (SPNT) (Solute carrier family 28 member 2)	SLC28A2 CNT2	Homo sapiens (Human)	658	FUNCTION: Sodium-dependent and purine-selective transporter (PubMed:9435697, PubMed:10087507). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (PubMed:9435697, PubMed:10087507, PubMed:21795683). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues (PubMed:9435697). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). {ECO:0000269|PubMed:10087507, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:9435697, ECO:0000305|PubMed:35307651}.		adenosine transport [GO:0032238]; azole transmembrane transport [GO:0045117]; inosine transport [GO:0035340]; neurotransmitter transport [GO:0006836]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine-containing compound transmembrane transport [GO:0072531]; retina homeostasis [GO:0001895]; transport across blood-brain barrier [GO:0150104]; uridine transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]	apicolateral plasma membrane [GO:0016327]; brush border membrane [GO:0031526]; coated vesicle [GO:0030135]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]	azole transmembrane transporter activity [GO:1901474]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; purine nucleoside transmembrane transporter activity [GO:0015211]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213]	apicolateral plasma membrane [GO:0016327]; brush border membrane [GO:0031526]; coated vesicle [GO:0030135]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; azole transmembrane transporter activity [GO:1901474]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; purine nucleoside transmembrane transporter activity [GO:0015211]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213]; adenosine transport [GO:0032238]; azole transmembrane transport [GO:0045117]; inosine transport [GO:0035340]; neurotransmitter transport [GO:0006836]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine-containing compound transmembrane transport [GO:0072531]; retina homeostasis [GO:0001895]; transport across blood-brain barrier [GO:0150104]; uridine transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:9435697}; Multi-pass membrane protein {ECO:0000255}. Apicolateral cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the apicolateral membranes of Sertoli cells and vascular endothelial cells in testis. {ECO:0000269|PubMed:35307651}.
O43889	reviewed	CREB3_HUMAN	Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)]	CREB3 LZIP	Homo sapiens (Human)	371	FUNCTION: Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:9271389, PubMed:19779205, PubMed:10984507, PubMed:15845366, PubMed:16940180). Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death (PubMed:15845366, PubMed:16940180). Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration (PubMed:19779205, PubMed:15001559, PubMed:17296613). Associates with chromatin to the HERPUD1 promoter (PubMed:16940180). Also induces transcriptional activation of chemokine receptors (PubMed:18587271, PubMed:17296613). {ECO:0000269|PubMed:10984507, ECO:0000269|PubMed:15001559, ECO:0000269|PubMed:15845366, ECO:0000269|PubMed:16940180, ECO:0000269|PubMed:17296613, ECO:0000269|PubMed:18587271, ECO:0000269|PubMed:19779205, ECO:0000269|PubMed:9271389}.; FUNCTION: (Microbial infection) Plays a role in human immunodeficiency virus type 1 (HIV-1) virus protein expression. {ECO:0000269|PubMed:17054986}.; FUNCTION: [Isoform 1]: (Microbial infection) May play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HCV) core protein. {ECO:0000269|PubMed:10675342}.; FUNCTION: [Isoform 1]: (Microbial infection) Plays a role in herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestering host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. {ECO:0000269|PubMed:10623756, ECO:0000269|PubMed:15705566}.; FUNCTION: [Isoform 2]: Functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells. {ECO:0000269|PubMed:19779205}.; FUNCTION: [Processed cyclic AMP-responsive element-binding protein 3]: This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many promoters to activate transcription of the genes. Binds to the unfolded protein response element (UPRE) consensus sequences sites. Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II (5'-ATTGG-N-CCACG-3'). {ECO:0000269|PubMed:16940180}.; FUNCTION: [Processed cyclic AMP-responsive element-binding protein 3]: (Microbial infection) Activates transcription of genes required for reactivation of the latent HSV-1 virus. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16. Binds DNA to the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many viral promoters. {ECO:0000269|PubMed:10623756}.; FUNCTION: [Processed cyclic AMP-responsive element-binding protein 3]: (Microbial infection) It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator HCV core protein. {ECO:0000269|PubMed:10675342}.	MISCELLANEOUS: [Isoform 2]: Does not contain a helical transmembrane domain. {ECO:0000305}.	chemotaxis [GO:0006935]; cytoplasmic sequestering of transcription factor [GO:0042994]; DNA-templated transcription [GO:0006351]; establishment of viral latency [GO:0019043]; induction of positive chemotaxis [GO:0050930]; integrated stress response signaling [GO:0140467]; negative regulation of cell cycle [GO:0045786]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of deacetylase activity [GO:0090045]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; regulation of apoptotic process [GO:0042981]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; release from viral latency [GO:0019046]; response to endoplasmic reticulum stress [GO:0034976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	cAMP response element binding protein binding [GO:0008140]; CCR1 chemokine receptor binding [GO:0031726]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coregulator binding [GO:0001221]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; cAMP response element binding protein binding [GO:0008140]; CCR1 chemokine receptor binding [GO:0031726]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coregulator binding [GO:0001221]; chemotaxis [GO:0006935]; cytoplasmic sequestering of transcription factor [GO:0042994]; DNA-templated transcription [GO:0006351]; establishment of viral latency [GO:0019043]; induction of positive chemotaxis [GO:0050930]; integrated stress response signaling [GO:0140467]; negative regulation of cell cycle [GO:0045786]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of deacetylase activity [GO:0090045]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; regulation of apoptotic process [GO:0042981]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; release from viral latency [GO:0019046]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10623756, ECO:0000269|PubMed:12138176, ECO:0000269|PubMed:18391022}; Single-pass type II membrane protein {ECO:0000255, ECO:0000269|PubMed:12138176}. Golgi apparatus {ECO:0000269|PubMed:10623756}. Note=Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (PubMed:10623756). Colocalizes with DCSTAMP in the ER membrane of immature dendritic cell (DC) (PubMed:20546900). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane (PubMed:10623756). {ECO:0000269|PubMed:10623756, ECO:0000269|PubMed:20546900}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Note=(Microbial infection) Sequestered into the cytoplasm by the HCV core protein. {ECO:0000269|PubMed:10675342}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:19779205}. Cytoplasm {ECO:0000269|PubMed:19779205}. Note=Predominantly in the nucleus (PubMed:19779205). Not associated with membranes (PubMed:19779205). {ECO:0000269|PubMed:19779205}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3]: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB). {ECO:0000269|PubMed:10675342, ECO:0000269|PubMed:15705566, ECO:0000269|PubMed:18391022, ECO:0000269|PubMed:20546900}.
O43895	reviewed	XPP2_HUMAN	Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2)	XPNPEP2	Homo sapiens (Human)	674	FUNCTION: Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin. {ECO:0000269|PubMed:15361070}.		proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	aminopeptidase activity [GO:0004177]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; aminopeptidase activity [GO:0004177]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q95333}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q95333}.
O43896	reviewed	KIF1C_HUMAN	Kinesin-like protein KIF1C	KIF1C KIAA0706	Homo sapiens (Human)	1103	FUNCTION: Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}.		anterograde neuronal dense core vesicle transport [GO:1990048]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; retrograde neuronal dense core vesicle transport [GO:1990049]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; kinesin complex [GO:0005871]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]; RNA binding [GO:0003723]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]; RNA binding [GO:0003723]; anterograde neuronal dense core vesicle transport [GO:1990048]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; retrograde neuronal dense core vesicle transport [GO:1990049]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
O43897	reviewed	TLL1_HUMAN	Tolloid-like protein 1 (EC 3.4.24.-)	TLL1 TLL	Homo sapiens (Human)	1013	FUNCTION: Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.		cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; protein processing [GO:0016485]; skeletal system development [GO:0001501]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; protein processing [GO:0016485]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O43900	reviewed	PRIC3_HUMAN	Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6)	PRICKLE3 LMO6	Homo sapiens (Human)	615	FUNCTION: Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}.		cell projection organization [GO:0030030]	mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	zinc ion binding [GO:0008270]	mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; zinc ion binding [GO:0008270]; cell projection organization [GO:0030030]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}. Cell membrane {ECO:0000250|UniProtKB:A8WH69}; Peripheral membrane protein {ECO:0000250|UniProtKB:A8WH69}; Cytoplasmic side {ECO:0000250|UniProtKB:A8WH69}. Mitochondrion {ECO:0000269|PubMed:32516135}. Note=Recruited by VANGL2 to anterior cell borders. This polarity is controlled by Wnt proteins (By similarity). WTIP is involved in the recruitment of PRICKLE3 to the basal body (By similarity). {ECO:0000250|UniProtKB:A8WH69}.
O43903	reviewed	GAS2_HUMAN	Growth arrest-specific protein 2 (GAS-2)	GAS2	Homo sapiens (Human)	313	FUNCTION: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). {ECO:0000250}.		actin crosslink formation [GO:0051764]; antral ovarian follicle growth [GO:0001547]; apoptotic process [GO:0006915]; basement membrane organization [GO:0071711]; cell cycle [GO:0007049]; initiation of primordial ovarian follicle growth [GO:0001544]; ovulation [GO:0030728]; regulation of cell cycle [GO:0051726]; regulation of cell shape [GO:0008360]; regulation of Notch signaling pathway [GO:0008593]	actin filament [GO:0005884]; cytosol [GO:0005829]; membrane [GO:0016020]	actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017]	actin filament [GO:0005884]; cytosol [GO:0005829]; membrane [GO:0016020]; actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017]; actin crosslink formation [GO:0051764]; antral ovarian follicle growth [GO:0001547]; apoptotic process [GO:0006915]; basement membrane organization [GO:0071711]; cell cycle [GO:0007049]; initiation of primordial ovarian follicle growth [GO:0001544]; ovulation [GO:0030728]; regulation of cell cycle [GO:0051726]; regulation of cell shape [GO:0008360]; regulation of Notch signaling pathway [GO:0008593]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:24706950}. Membrane {ECO:0000250|UniProtKB:P11862}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11862}. Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles. {ECO:0000250|UniProtKB:P11862}.
O43909	reviewed	EXTL3_HUMAN	Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3)	EXTL3 EXTL1L EXTR1 KIAA0519	Homo sapiens (Human)	919	FUNCTION: Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS) (PubMed:28132690, PubMed:28148688). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker (PubMed:11390981, PubMed:35676258). May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity) (PubMed:11390981, PubMed:35676258). Lacks glucuronyl transferase II (GlcAT-II) activity (PubMed:11390981, PubMed:35676258). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) (PubMed:28132690, PubMed:28148688, PubMed:11390981, PubMed:22727489, PubMed:35676258). Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion (By similarity). {ECO:0000250|UniProtKB:Q9WVL6, ECO:0000269|PubMed:11390981, ECO:0000269|PubMed:22727489, ECO:0000269|PubMed:28132690, ECO:0000269|PubMed:28148688, ECO:0000269|PubMed:35676258}.; FUNCTION: Receptor for REG3A, REG3B and REG3G, induces the activation of downstream signaling pathways such as PI3K-AKT or RAS-RAF-MEK-ERK signaling pathway (PubMed:22727489, PubMed:34099862, PubMed:27830702). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation (PubMed:22727489). Required for the inhibition of skin inflammation mediated by REGA through the activation of PI3K-AKT-STAT3 pathway (PubMed:27830702). Required for the function of REGA and REG3G in glucose tolerance in pancreas (PubMed:19158046). Expressed in microglia, is activated by nociceptor-derived REG3G in response to endotoxins, leading to the inhibition of kynurenine pathway to prevent endotoxic death (By similarity). {ECO:0000250|UniProtKB:Q9WVL6, ECO:0000269|PubMed:19158046, ECO:0000269|PubMed:22727489, ECO:0000269|PubMed:27830702, ECO:0000269|PubMed:34099862}.		heparan sulfate proteoglycan biosynthetic process [GO:0015012]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of keratinocyte differentiation [GO:0045617]; positive regulation of cell growth [GO:0030307]; positive regulation of detection of glucose [GO:2000972]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888]; glycosyltransferase activity [GO:0016757]; magnesium ion binding [GO:0000287]; protein-hormone receptor activity [GO:0016500]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888]; glycosyltransferase activity [GO:0016757]; magnesium ion binding [GO:0000287]; protein-hormone receptor activity [GO:0016500]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of keratinocyte differentiation [GO:0045617]; positive regulation of cell growth [GO:0030307]; positive regulation of detection of glucose [GO:2000972]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10639137}; Single-pass type II membrane protein {ECO:0000269|PubMed:10639137}. Golgi apparatus {ECO:0000269|PubMed:28132690}. Cell membrane {ECO:0000269|PubMed:19158046}. Nucleus {ECO:0000269|PubMed:19158046}. Note=Interaction with REG3A induces its translocation to the nucleus. {ECO:0000269|PubMed:19158046}.
O43913	reviewed	ORC5_HUMAN	Origin recognition complex subunit 5	ORC5 ORC5L	Homo sapiens (Human)	435	FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. {ECO:0000269|PubMed:31160578}.	MISCELLANEOUS: [Isoform 2]: Does not interact with ORC2. {ECO:0000305}.	DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; regulation of DNA replication [GO:0006275]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]	ATP binding [GO:0005524]; DNA replication origin binding [GO:0003688]; nucleotide binding [GO:0000166]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]; ATP binding [GO:0005524]; DNA replication origin binding [GO:0003688]; nucleotide binding [GO:0000166]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; regulation of DNA replication [GO:0006275]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31160578}. Chromosome {ECO:0000269|PubMed:31160578}.
O43914	reviewed	TYOBP_HUMAN	TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein)	TYROBP DAP12 KARAP	Homo sapiens (Human)	113	FUNCTION: Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (PubMed:9490415, PubMed:9655483, PubMed:10604985). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (PubMed:9490415). Also has an inhibitory role in some cells (PubMed:21727189). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (PubMed:15557162, PubMed:16920917, PubMed:17928527, PubMed:26221034). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (PubMed:10449773). Associates with natural killer (NK) cell receptors such as KIR2DS2 and the KLRD1/KLRC2 heterodimer to mediate NK cell activation (PubMed:9490415, PubMed:9655483, PubMed:23715743). Also enhances trafficking and cell surface expression of NK cell receptors KIR2DS1, KIR2DS2 and KIR2DS4 and ensures their stability at the cell surface (PubMed:23715743). Associates with SIRPB1 to mediate activation of myeloid cells such as monocytes and dendritic cells (PubMed:10604985). Associates with TREM1 to mediate activation of neutrophils and monocytes (PubMed:10799849). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (PubMed:18957693). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (PubMed:25957402). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes pro-inflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity). Positively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allostimulatory ability (By similarity). Negatively regulates B cell proliferation (PubMed:21727189). Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity). Positively regulates multinucleation during osteoclast development (By similarity). {ECO:0000250|UniProtKB:O54885, ECO:0000269|PubMed:10449773, ECO:0000269|PubMed:10604985, ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:11602640, ECO:0000269|PubMed:15557162, ECO:0000269|PubMed:16920917, ECO:0000269|PubMed:17928527, ECO:0000269|PubMed:18957693, ECO:0000269|PubMed:21727189, ECO:0000269|PubMed:23715743, ECO:0000269|PubMed:25957402, ECO:0000269|PubMed:26221034, ECO:0000269|PubMed:9490415, ECO:0000269|PubMed:9655483}.		actin cytoskeleton organization [GO:0030036]; apoptotic cell clearance [GO:0043277]; cellular defense response [GO:0006968]; forebrain development [GO:0030900]; intracellular signal transduction [GO:0035556]; microglial cell activation involved in immune response [GO:0002282]; myeloid leukocyte activation [GO:0002274]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of transforming growth factor beta1 production [GO:0032911]; negative regulation of type I interferon production [GO:0032480]; neutrophil activation involved in immune response [GO:0002283]; osteoclast differentiation [GO:0030316]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of osteoclast development [GO:2001206]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of tumor necrosis factor production [GO:0032760]; protein stabilization [GO:0050821]; response to axon injury [GO:0048678]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stimulatory killer cell immunoglobulin-like receptor signaling pathway [GO:0002222]	cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; actin cytoskeleton organization [GO:0030036]; apoptotic cell clearance [GO:0043277]; cellular defense response [GO:0006968]; forebrain development [GO:0030900]; intracellular signal transduction [GO:0035556]; microglial cell activation involved in immune response [GO:0002282]; myeloid leukocyte activation [GO:0002274]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of transforming growth factor beta1 production [GO:0032911]; negative regulation of type I interferon production [GO:0032480]; neutrophil activation involved in immune response [GO:0002283]; osteoclast differentiation [GO:0030316]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of osteoclast development [GO:2001206]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of tumor necrosis factor production [GO:0032760]; protein stabilization [GO:0050821]; response to axon injury [GO:0048678]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stimulatory killer cell immunoglobulin-like receptor signaling pathway [GO:0002222]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9655483}; Single-pass type I membrane protein {ECO:0000255}.
O43915	reviewed	VEGFD_HUMAN	Vascular endothelial growth factor D (VEGF-D) (c-Fos-induced growth factor) (FIGF)	VEGFD FIGF	Homo sapiens (Human)	354	FUNCTION: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. {ECO:0000269|PubMed:21148085}.		dopaminergic neuron differentiation [GO:0071542]; fibroblast proliferation [GO:0048144]; induction of positive chemotaxis [GO:0050930]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of protein phosphorylation [GO:0001934]; response to bacterium [GO:0009617]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]	chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; platelet-derived growth factor receptor binding [GO:0005161]; vascular endothelial growth factor receptor 3 binding [GO:0043185]; vascular endothelial growth factor receptor binding [GO:0005172]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; platelet-derived growth factor receptor binding [GO:0005161]; vascular endothelial growth factor receptor 3 binding [GO:0043185]; vascular endothelial growth factor receptor binding [GO:0005172]; dopaminergic neuron differentiation [GO:0071542]; fibroblast proliferation [GO:0048144]; induction of positive chemotaxis [GO:0050930]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of protein phosphorylation [GO:0001934]; response to bacterium [GO:0009617]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]	SUBCELLULAR LOCATION: Secreted.
O43916	reviewed	CHST1_HUMAN	Carbohydrate sulfotransferase 1 (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1) (GST-1) (Keratan sulfate Gal-6 sulfotransferase) (KS6ST) (KSGal6ST) (KSST) (EC 2.8.2.21)	CHST1	Homo sapiens (Human)	411	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (PubMed:17690104, PubMed:9405439, PubMed:10642612). Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer (PubMed:9405439). Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain (By similarity). Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking (PubMed:10330415). Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures (PubMed:10642612). {ECO:0000250|UniProtKB:Q9EQC0, ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:10642612, ECO:0000269|PubMed:17690104, ECO:0000269|PubMed:9405439}.		galactose metabolic process [GO:0006012]; inflammatory response [GO:0006954]; keratan sulfate biosynthetic process [GO:0018146]; keratan sulfate metabolic process [GO:0042339]; N-acetylglucosamine metabolic process [GO:0006044]; polysaccharide metabolic process [GO:0005976]; sulfur compound metabolic process [GO:0006790]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	keratan sulfotransferase activity [GO:0045130]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; keratan sulfotransferase activity [GO:0045130]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146]; galactose metabolic process [GO:0006012]; inflammatory response [GO:0006954]; keratan sulfate biosynthetic process [GO:0018146]; keratan sulfate metabolic process [GO:0042339]; N-acetylglucosamine metabolic process [GO:0006044]; polysaccharide metabolic process [GO:0005976]; sulfur compound metabolic process [GO:0006790]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
O43918	reviewed	AIRE_HUMAN	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)	AIRE APECED	Homo sapiens (Human)	545	FUNCTION: Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (PubMed:26084028). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program. Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression. Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes. In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection. In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (By similarity). {ECO:0000250|UniProtKB:Q9Z0E3, ECO:0000269|PubMed:11274163, ECO:0000269|PubMed:18292755, ECO:0000269|PubMed:26084028, ECO:0000305|PubMed:19302042, ECO:0000305|PubMed:26972725}.		central tolerance induction to self antigen [GO:0002509]; humoral immune response [GO:0006959]; immune response [GO:0006955]; negative thymic T cell selection [GO:0045060]; peripheral T cell tolerance induction [GO:0002458]; positive regulation of chemokine production [GO:0032722]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of thymocyte migration [GO:2000410]; thymus epithelium morphogenesis [GO:0097536]; transcription by RNA polymerase II [GO:0006366]	cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; translation regulator activity [GO:0045182]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; translation regulator activity [GO:0045182]; zinc ion binding [GO:0008270]; central tolerance induction to self antigen [GO:0002509]; humoral immune response [GO:0006959]; immune response [GO:0006955]; negative thymic T cell selection [GO:0045060]; peripheral T cell tolerance induction [GO:0002458]; positive regulation of chemokine production [GO:0032722]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of thymocyte migration [GO:2000410]; thymus epithelium morphogenesis [GO:0097536]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14974083, ECO:0000269|PubMed:26084028}. Cytoplasm {ECO:0000269|PubMed:11274163, ECO:0000269|PubMed:14974083}. Note=Predominantly nuclear but also cytoplasmic (PubMed:11274163, PubMed:14974083). Found in nuclear body-like structures (dots) and in a filamentous vimentin-like pattern (PubMed:11274163, PubMed:14974083, PubMed:26084028). Associated with tubular structures (PubMed:11274163, PubMed:14974083). {ECO:0000269|PubMed:11274163, ECO:0000269|PubMed:14974083, ECO:0000269|PubMed:26084028}.
O43920	reviewed	NDUS5_HUMAN	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (Complex I-15 kDa) (CI-15 kDa) (NADH-ubiquinone oxidoreductase 15 kDa subunit)	NDUFS5	Homo sapiens (Human)	106	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}. Mitochondrion intermembrane space {ECO:0000305}.
O43921	reviewed	EFNA2_HUMAN	Ephrin-A2 (EPH-related receptor tyrosine kinase ligand 6) (LERK-6) (HEK7 ligand) (HEK7-L)	EFNA2 EPLG6 LERK6	Homo sapiens (Human)	213	FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; bone remodeling [GO:0046849]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]; olfactory bulb development [GO:0021772]; osteoclast differentiation [GO:0030316]	neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	ephrin receptor binding [GO:0046875]	neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; ephrin receptor binding [GO:0046875]; axon guidance [GO:0007411]; bone remodeling [GO:0046849]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]; olfactory bulb development [GO:0021772]; osteoclast differentiation [GO:0030316]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
O43924	reviewed	PDE6D_HUMAN	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17)	PDE6D PDED	Homo sapiens (Human)	150	FUNCTION: Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). {ECO:0000250|UniProtKB:O55057, ECO:0000269|PubMed:10518933, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23559067, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24166846, ECO:0000269|PubMed:9712853}.		response to stimulus [GO:0050896]; visual perception [GO:0007601]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]	GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:9712853}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9712853}; Peripheral membrane protein {ECO:0000269|PubMed:9712853}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24166846}.
O43927	reviewed	CXL13_HUMAN	C-X-C motif chemokine 13 (Angie) (B cell-attracting chemokine 1) (BCA-1) (B lymphocyte chemoattractant) (CXC chemokine BLC) (Small-inducible cytokine B13)	CXCL13 BCA1 BLC SCYB13	Homo sapiens (Human)	109	FUNCTION: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.		activation of GTPase activity [GO:0090630]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; B cell chemotaxis [GO:0035754]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chronic inflammatory response [GO:0002544]; defense response to bacterium [GO:0042742]; endothelial cell chemotaxis to fibroblast growth factor [GO:0035768]; germinal center formation [GO:0002467]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis across high endothelial venule [GO:0002518]; negative regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000545]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of integrin activation [GO:0033625]; positive regulation of T cell chemotaxis [GO:0010820]; regulation of angiogenesis [GO:0045765]; regulation of humoral immune response [GO:0002920]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR10 chemokine receptor binding [GO:0031735]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; CXCR5 chemokine receptor binding [GO:0031724]; fibroblast growth factor binding [GO:0017134]; heparin binding [GO:0008201]; receptor ligand activity [GO:0048018]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR10 chemokine receptor binding [GO:0031735]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; CXCR5 chemokine receptor binding [GO:0031724]; fibroblast growth factor binding [GO:0017134]; heparin binding [GO:0008201]; receptor ligand activity [GO:0048018]; activation of GTPase activity [GO:0090630]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; B cell chemotaxis [GO:0035754]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chronic inflammatory response [GO:0002544]; defense response to bacterium [GO:0042742]; endothelial cell chemotaxis to fibroblast growth factor [GO:0035768]; germinal center formation [GO:0002467]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis across high endothelial venule [GO:0002518]; negative regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000545]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of integrin activation [GO:0033625]; positive regulation of T cell chemotaxis [GO:0010820]; regulation of angiogenesis [GO:0045765]; regulation of humoral immune response [GO:0002920]	SUBCELLULAR LOCATION: Secreted.
O43929	reviewed	ORC4_HUMAN	Origin recognition complex subunit 4	ORC4 ORC4L	Homo sapiens (Human)	436	FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655}.		DNA replication initiation [GO:0006270]; polar body extrusion after meiotic divisions [GO:0040038]; protein polymerization [GO:0051258]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear origin of replication recognition complex [GO:0005664]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA replication origin binding [GO:0003688]; nucleotide binding [GO:0000166]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear origin of replication recognition complex [GO:0005664]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA replication origin binding [GO:0003688]; nucleotide binding [GO:0000166]; DNA replication initiation [GO:0006270]; polar body extrusion after meiotic divisions [GO:0040038]; protein polymerization [GO:0051258]	SUBCELLULAR LOCATION: Nucleus.
O43933	reviewed	PEX1_HUMAN	Peroxisomal ATPase PEX1 (EC 3.6.4.-) (Peroxin-1) (Peroxisome biogenesis disorder protein 1) (Peroxisome biogenesis factor 1)	PEX1	Homo sapiens (Human)	1283	FUNCTION: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:11439091, PubMed:16314507, PubMed:16854980, PubMed:21362118, PubMed:29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29884772). {ECO:0000269|PubMed:11439091, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118, ECO:0000269|PubMed:29884772}.		microtubule-based peroxisome localization [GO:0060152]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein targeting to peroxisome [GO:0006625]; protein unfolding [GO:0043335]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein transporter activity [GO:0140318]; protein-containing complex binding [GO:0044877]; ubiquitin-dependent protein binding [GO:0140036]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein transporter activity [GO:0140318]; protein-containing complex binding [GO:0044877]; ubiquitin-dependent protein binding [GO:0140036]; microtubule-based peroxisome localization [GO:0060152]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein targeting to peroxisome [GO:0006625]; protein unfolding [GO:0043335]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16854980}. Peroxisome membrane {ECO:0000269|PubMed:11439091, ECO:0000269|PubMed:12717447, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118}. Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes. {ECO:0000269|PubMed:12717447, ECO:0000269|PubMed:16854980}.
O60216	reviewed	RAD21_HUMAN	Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)]	RAD21 HR21 KIAA0078 NXP1 SCC1	Homo sapiens (Human)	631	FUNCTION: [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250|UniProtKB:Q61550, ECO:0000250|UniProtKB:Q6TEL1, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:25575569, ECO:0000305|PubMed:25575569}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}.		apoptotic process [GO:0006915]; cell division [GO:0051301]; chromatin looping [GO:0140588]; chromosome segregation [GO:0007059]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of sister chromatid cohesion [GO:0045876]; protein localization to chromatin [GO:0071168]; reciprocal meiotic recombination [GO:0007131]; regulation of transcription by RNA polymerase II [GO:0006357]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; response to hypoxia [GO:0001666]; sister chromatid cohesion [GO:0007062]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; meiotic cohesin complex [GO:0030893]; membrane [GO:0016020]; midbody [GO:0030496]; mitotic cohesin complex [GO:0030892]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; lncRNA binding [GO:0106222]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; meiotic cohesin complex [GO:0030893]; membrane [GO:0016020]; midbody [GO:0030496]; mitotic cohesin complex [GO:0030892]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; lncRNA binding [GO:0106222]; apoptotic process [GO:0006915]; cell division [GO:0051301]; chromatin looping [GO:0140588]; chromosome segregation [GO:0007059]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of sister chromatid cohesion [GO:0045876]; protein localization to chromatin [GO:0071168]; reciprocal meiotic recombination [GO:0007131]; regulation of transcription by RNA polymerase II [GO:0006357]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; response to hypoxia [GO:0001666]; sister chromatid cohesion [GO:0007062]	SUBCELLULAR LOCATION: [Double-strand-break repair protein rad21 homolog]: Nucleus {ECO:0000269|PubMed:11073952, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:12417729}. Nucleus matrix {ECO:0000269|PubMed:10623634, ECO:0000269|PubMed:11590136}. Chromosome {ECO:0000269|PubMed:11073952, ECO:0000269|PubMed:11590136}. Chromosome, centromere {ECO:0000269|PubMed:11073952}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:11073952, ECO:0000269|PubMed:11590136}. Note=Associates with chromatin (PubMed:11590136, PubMed:11073952). Before prophase, scattered along chromosome arms (PubMed:11073952). During prophase and prometaphase, most cohesins dissociate from the arms of condensing chromosome, possibly through PLK1-mediated phosphorylation (PubMed:11931760). A small amount of cohesin remains in centromeric regions and is removed from chromosomes only at the onset of anaphase. At anaphase, cleavage by separase/ESPL1 leads to the dissociation of cohesin from chromosomes and chromosome separation (PubMed:11073952, PubMed:11509732). {ECO:0000269|PubMed:11073952, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:11931760}.; SUBCELLULAR LOCATION: [64-kDa C-terminal product]: Cytoplasm, cytosol {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}. Nucleus {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}.
O60218	reviewed	AK1BA_HUMAN	Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase)	AKR1B10 AKR1B11	Homo sapiens (Human)	316	FUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:18087047, ECO:0000269|PubMed:19013440, ECO:0000269|PubMed:19563777, ECO:0000269|PubMed:9565553}.	MISCELLANEOUS: Has no counterpart in murine and rat species. {ECO:0000305}.	cellular detoxification of aldehyde [GO:0110095]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; farnesol catabolic process [GO:0016488]; retinoid metabolic process [GO:0001523]	cytosol [GO:0005829]; extracellular region [GO:0005576]; lysosome [GO:0005764]; mitochondrion [GO:0005739]	alcohol dehydrogenase (NADP+) activity [GO:0008106]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; allyl-alcohol dehydrogenase activity [GO:0047655]; geranylgeranyl reductase activity [GO:0045550]; indanol dehydrogenase activity [GO:0047718]; NADP-retinol dehydrogenase activity [GO:0052650]; retinal dehydrogenase activity [GO:0001758]	cytosol [GO:0005829]; extracellular region [GO:0005576]; lysosome [GO:0005764]; mitochondrion [GO:0005739]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; allyl-alcohol dehydrogenase activity [GO:0047655]; geranylgeranyl reductase activity [GO:0045550]; indanol dehydrogenase activity [GO:0047718]; NADP-retinol dehydrogenase activity [GO:0052650]; retinal dehydrogenase activity [GO:0001758]; cellular detoxification of aldehyde [GO:0110095]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; farnesol catabolic process [GO:0016488]; retinoid metabolic process [GO:0001523]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:21585341}. Secreted {ECO:0000269|PubMed:21585341}. Note=Secreted through a lysosome-mediated non-classical pathway.
O60220	reviewed	TIM8A_HUMAN	Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein)	TIMM8A DDP DDP1 TIM8A	Homo sapiens (Human)	97	FUNCTION: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}.		nervous system development [GO:0007399]; protein insertion into mitochondrial inner membrane [GO:0045039]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; mitochondrion [GO:0005739]	identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; mitochondrion [GO:0005739]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; nervous system development [GO:0007399]; protein insertion into mitochondrial inner membrane [GO:0045039]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11489896}; Peripheral membrane protein {ECO:0000269|PubMed:11489896}; Intermembrane side {ECO:0000269|PubMed:11489896}.
O60229	reviewed	KALRN_HUMAN	Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain)	KALRN DUET DUO HAPIP TRAD	Homo sapiens (Human)	2986	FUNCTION: Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. {ECO:0000269|PubMed:10023074}.	MISCELLANEOUS: Called DUO because the encoded protein is closely related to but shorter than TRIO.	axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; protein phosphorylation [GO:0006468]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]	ATP binding [GO:0005524]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; ATP binding [GO:0005524]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; protein phosphorylation [GO:0006468]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10023074}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10023074}. Note=Associated with the cytoskeleton.
O60231	reviewed	DHX16_HUMAN	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16)	DHX16 DBP2 DDX16 KIAA0577 PRP2	Homo sapiens (Human)	1041	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Plays also a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596). {ECO:0000269|PubMed:20423332, ECO:0000269|PubMed:20841358, ECO:0000269|PubMed:25296192, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:35263596, ECO:0000305|PubMed:33509932}.		antiviral innate immune response [GO:0140374]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; molecular adaptor activity [GO:0060090]; pattern recognition receptor activity [GO:0038187]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; ubiquitin binding [GO:0043130]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; molecular adaptor activity [GO:0060090]; pattern recognition receptor activity [GO:0038187]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; ubiquitin binding [GO:0043130]; antiviral innate immune response [GO:0140374]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20423332, ECO:0000269|PubMed:20841358, ECO:0000269|PubMed:25296192, ECO:0000269|PubMed:29360106}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20423332}. Cytoplasm {ECO:0000269|PubMed:35263596}.
O60232	reviewed	ZNRD2_HUMAN	Protein ZNRD2 (Autoantigen p27) (Sjoegren syndrome/scleroderma autoantigen 1) (Zinc ribbon domain-containing protein 2)	ZNRD2 SSSCA1	Homo sapiens (Human)	199	FUNCTION: Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies. {ECO:0000305|PubMed:9486406}.		cell division [GO:0051301]; mitotic cell cycle [GO:0000278]			cell division [GO:0051301]; mitotic cell cycle [GO:0000278]	
O60235	reviewed	TM11D_HUMAN	Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain]	TMPRSS11D HAT	Homo sapiens (Human)	418	FUNCTION: May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. {ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:24227843}.		proteolysis [GO:0006508]; respiratory gaseous exchange by respiratory system [GO:0007585]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted.; SUBCELLULAR LOCATION: [Transmembrane protease serine 11D catalytic chain]: Secreted. Note=Activated by cleavage and secreted.
O60237	reviewed	MYPT2_HUMAN	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)	PPP1R12B MYPT2	Homo sapiens (Human)	982	FUNCTION: Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 4. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative promoter usage. {ECO:0000305}.	regulation of muscle contraction [GO:0006937]; signal transduction [GO:0007165]	A band [GO:0031672]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; Z disc [GO:0030018]	enzyme activator activity [GO:0008047]; enzyme inhibitor activity [GO:0004857]; phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901]	A band [GO:0031672]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; Z disc [GO:0030018]; enzyme activator activity [GO:0008047]; enzyme inhibitor activity [GO:0004857]; phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901]; regulation of muscle contraction [GO:0006937]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12923170}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:12923170}. Note=Along actomyosin filaments. {ECO:0000269|PubMed:12923170}.
O60238	reviewed	BNI3L_HUMAN	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L)	BNIP3L BNIP3A BNIP3H NIX	Homo sapiens (Human)	219	FUNCTION: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.		cellular response to hypoxia [GO:0071456]; defense response to virus [GO:0051607]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrial protein catabolic process [GO:0035694]; negative regulation of apoptotic process [GO:0043066]; negative regulation of programmed cell death [GO:0043069]; positive regulation of apoptotic process [GO:0043065]; positive regulation of macroautophagy [GO:0016239]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of programmed cell death [GO:0043067]; regulation of protein targeting to mitochondrion [GO:1903214]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein homodimerization activity [GO:0042803]; cellular response to hypoxia [GO:0071456]; defense response to virus [GO:0051607]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrial protein catabolic process [GO:0035694]; negative regulation of apoptotic process [GO:0043066]; negative regulation of programmed cell death [GO:0043069]; positive regulation of apoptotic process [GO:0043065]; positive regulation of macroautophagy [GO:0016239]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of programmed cell death [GO:0043067]; regulation of protein targeting to mitochondrion [GO:1903214]	SUBCELLULAR LOCATION: Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Colocalizes with SPATA18 at the mitochondrion outer membrane.
O60239	reviewed	3BP5_HUMAN	SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK)	SH3BP5 SAB	Homo sapiens (Human)	455	FUNCTION: Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}.		intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase inhibitor activity [GO:0004860]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase inhibitor activity [GO:0004860]; SH3 domain binding [GO:0017124]; intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:30217979}; Peripheral membrane protein {ECO:0000269|PubMed:30217979}. Mitochondrion {ECO:0000269|PubMed:12167088}. Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes. {ECO:0000269|PubMed:30217979}.
O60240	reviewed	PLIN1_HUMAN	Perilipin-1 (Lipid droplet-associated protein)	PLIN1 PERI PLIN	Homo sapiens (Human)	522	FUNCTION: Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269|PubMed:23399566}.		cellular response to cold [GO:0070417]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]	lipid binding [GO:0008289]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; lipid binding [GO:0008289]; cellular response to cold [GO:0070417]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:23399566}. Lipid droplet {ECO:0000269|PubMed:23399566, ECO:0000305|PubMed:26357594}. Note=Lipid droplet surface-associated. {ECO:0000269|PubMed:23399566}.
O60241	reviewed	AGRB2_HUMAN	Adhesion G protein-coupled receptor B2 (Brain-specific angiogenesis inhibitor 2)	ADGRB2 BAI2	Homo sapiens (Human)	1585	FUNCTION: Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity). {ECO:0000250|UniProtKB:Q8CGM1, ECO:0000269|PubMed:20367554, ECO:0000269|PubMed:28891236}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcineurin-NFAT signaling cascade [GO:0033173]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of angiogenesis [GO:0016525]; peripheral nervous system development [GO:0007422]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcineurin-NFAT signaling cascade [GO:0033173]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of angiogenesis [GO:0016525]; peripheral nervous system development [GO:0007422]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28891236}; Multi-pass membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:25326458}.
O60242	reviewed	AGRB3_HUMAN	Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3)	ADGRB3 BAI3 KIAA0550	Homo sapiens (Human)	1522	FUNCTION: Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399). {ECO:0000250|UniProtKB:Q80ZF8, ECO:0000269|PubMed:24567399}.	MISCELLANEOUS: Autoproteolysis appears to be cell specific, does not readily undergo proteolytic cleavage in HEK293T cells. {ECO:0000269|PubMed:25713288}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; maintenance of synapse structure [GO:0099558]; motor learning [GO:0061743]; myoblast fusion [GO:0007520]; negative regulation of angiogenesis [GO:0016525]; neuron remodeling [GO:0016322]; positive regulation of synapse assembly [GO:0051965]; regulation of dendrite morphogenesis [GO:0048814]; regulation of synapse maturation [GO:0090128]; regulation of synapse pruning [GO:1905806]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density membrane [GO:0098839]; synaptic cleft [GO:0043083]	G protein-coupled receptor activity [GO:0004930]; GTPase activator activity [GO:0005096]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density membrane [GO:0098839]; synaptic cleft [GO:0043083]; G protein-coupled receptor activity [GO:0004930]; GTPase activator activity [GO:0005096]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; maintenance of synapse structure [GO:0099558]; motor learning [GO:0061743]; myoblast fusion [GO:0007520]; negative regulation of angiogenesis [GO:0016525]; neuron remodeling [GO:0016322]; positive regulation of synapse assembly [GO:0051965]; regulation of dendrite morphogenesis [GO:0048814]; regulation of synapse maturation [GO:0090128]; regulation of synapse pruning [GO:1905806]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21262840, ECO:0000269|PubMed:22333914}; Multi-pass membrane protein {ECO:0000255}.
O60243	reviewed	H6ST1_HUMAN	Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST-1) (EC 2.8.2.-)	HS6ST1 HS6ST	Homo sapiens (Human)	411	FUNCTION: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. {ECO:0000269|PubMed:21700882, ECO:0000269|PubMed:9535912}.		angiogenesis [GO:0001525]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; labyrinthine layer blood vessel development [GO:0060716]; lung alveolus development [GO:0048286]; neuron development [GO:0048666]	Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	heparan sulfate 6-O-sulfotransferase activity [GO:0017095]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; heparan sulfate 6-O-sulfotransferase activity [GO:0017095]; sulfotransferase activity [GO:0008146]; angiogenesis [GO:0001525]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; labyrinthine layer blood vessel development [GO:0060716]; lung alveolus development [GO:0048286]; neuron development [GO:0048666]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
O60244	reviewed	MED14_HUMAN	Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)	MED14 ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170	Homo sapiens (Human)	1454	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}.		positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear receptor coactivator activity [GO:0030374]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear receptor coactivator activity [GO:0030374]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O60248	reviewed	SOX15_HUMAN	Protein SOX-15 (Protein SOX-12) (Protein SOX-20)	SOX15 SOX12 SOX20 SOX26 SOX27	Homo sapiens (Human)	233	FUNCTION: Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity). Acts as a transcriptional activator and repressor (By similarity). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity). Regulates transcription of HRC via binding to it proximal enhancer region (By similarity). Involved in skeletal muscle regeneration (By similarity). Also plays a role in the development of myogenic precursor cells (By similarity). {ECO:0000250|UniProtKB:P43267}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; male gonad development [GO:0008584]; myoblast development [GO:0048627]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue regeneration [GO:0043403]; trophoblast giant cell differentiation [GO:0060707]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; male gonad development [GO:0008584]; myoblast development [GO:0048627]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue regeneration [GO:0043403]; trophoblast giant cell differentiation [GO:0060707]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
O60256	reviewed	KPRB_HUMAN	Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41)	PRPSAP2	Homo sapiens (Human)	369	FUNCTION: Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.		5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; bone development [GO:0060348]; nucleobase-containing compound metabolic process [GO:0006139]; purine nucleotide biosynthetic process [GO:0006164]	cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189]	ATP binding [GO:0005524]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749]	cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189]; ATP binding [GO:0005524]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; bone development [GO:0060348]; nucleobase-containing compound metabolic process [GO:0006139]; purine nucleotide biosynthetic process [GO:0006164]	
O60258	reviewed	FGF17_HUMAN	Fibroblast growth factor 17 (FGF-17)	FGF17 UNQ161/PRO187	Homo sapiens (Human)	216	FUNCTION: Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. {ECO:0000269|PubMed:16597617}.		animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	growth factor activity [GO:0008083]; type 1 fibroblast growth factor receptor binding [GO:0005105]; type 2 fibroblast growth factor receptor binding [GO:0005111]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth factor activity [GO:0008083]; type 1 fibroblast growth factor receptor binding [GO:0005105]; type 2 fibroblast growth factor receptor binding [GO:0005111]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
O60259	reviewed	KLK8_HUMAN	Kallikrein-8 (hK8) (EC 3.4.21.118) (Neuropsin) (NP) (Ovasin) (Serine protease 19) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein)	KLK8 NRPN PRSS19 TADG14 UNQ283/PRO322	Homo sapiens (Human)	260	FUNCTION: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269|PubMed:16337200}.	MISCELLANEOUS: Expressed at high levels in serum, ascites fluid and tumor cytosol of advanced stage ovarian cancer patients and may serve as a marker of ovarian cancer.; MISCELLANEOUS: [Isoform 2]: Produced as a result of a human-specific mutation which is not found in other primates. {ECO:0000305}.	keratinocyte proliferation [GO:0043616]; memory [GO:0007613]; neuron projection morphogenesis [GO:0048812]; proteolysis [GO:0006508]; regulation of synapse organization [GO:0050807]; response to wounding [GO:0009611]; synapse organization [GO:0050808]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; serine protease inhibitor complex [GO:0097180]	serine-type endopeptidase activity [GO:0004252]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; serine protease inhibitor complex [GO:0097180]; serine-type endopeptidase activity [GO:0004252]; keratinocyte proliferation [GO:0043616]; memory [GO:0007613]; neuron projection morphogenesis [GO:0048812]; proteolysis [GO:0006508]; regulation of synapse organization [GO:0050807]; response to wounding [GO:0009611]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17761692}. Cytoplasm {ECO:0000269|PubMed:17761692}. Note=Shows a cytoplasmic distribution in the keratinocytes.
O60260	reviewed	PRKN_HUMAN	E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)	PRKN PARK2	Homo sapiens (Human)	465	FUNCTION: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536, PubMed:32047033, PubMed:29311685, PubMed:22396657). Substrates include SYT11 and VDAC1 (PubMed:32047033, PubMed:29311685). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536, PubMed:22396657). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951, PubMed:32047033, PubMed:25474007). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11431533, PubMed:11590439, PubMed:15105460, PubMed:19229105, PubMed:15728840). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:32047033, PubMed:19029340, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291, PubMed:18957282, PubMed:21376232, PubMed:22396657, PubMed:24660806, PubMed:25474007, PubMed:24784582, PubMed:11439185, PubMed:22082830, PubMed:23933751). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:32047033, PubMed:19029340, PubMed:19801972, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291, PubMed:21376232, PubMed:22396657, PubMed:11439185, PubMed:22082830, PubMed:23933751, PubMed:33499712). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:24660806, PubMed:25474007, PubMed:24784582, PubMed:25527291). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:27534820, PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:21753002, PubMed:23620051, PubMed:24896179, PubMed:25527291, PubMed:22396657, PubMed:23933751). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (PubMed:25621951, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:23620051). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:23620051). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (PubMed:21376232). Limits the production of reactive oxygen species (ROS) (PubMed:18541373). Regulates cyclin-E during neuronal apoptosis (PubMed:12628165). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (PubMed:12719539). {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:10973942, ECO:0000269|PubMed:11431533, ECO:0000269|PubMed:11439185, ECO:0000269|PubMed:11590439, ECO:0000269|PubMed:12150907, ECO:0000269|PubMed:12628165, ECO:0000269|PubMed:12719539, ECO:0000269|PubMed:15105460, ECO:0000269|PubMed:15728840, ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19029340, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19801972, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:22082830, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951, ECO:0000269|PubMed:27534820, ECO:0000269|PubMed:29311685, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:33499712}.	MISCELLANEOUS: The parkin locus (PRKN), adjacent to the 6q telomere is hyper-recombinable and lies within FRA6E, the third most common fragile site in tumor tissue.	adult locomotory behavior [GO:0008344]; aggresome assembly [GO:0070842]; amyloid fibril formation [GO:1990000]; autophagy of mitochondrion [GO:0000422]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; cellular response to unfolded protein [GO:0034620]; central nervous system development [GO:0007417]; dopamine metabolic process [GO:0042417]; dopamine uptake involved in synaptic transmission [GO:0051583]; ERAD pathway [GO:0036503]; free ubiquitin chain polymerization [GO:0010994]; learning [GO:0007612]; macroautophagy [GO:0016236]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005]; mitochondrion to lysosome transport [GO:0099074]; mitophagy [GO:0000423]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of gene expression [GO:0010629]; negative regulation of glucokinase activity [GO:0033132]; negative regulation of insulin secretion [GO:0046676]; negative regulation of intralumenal vesicle formation [GO:1905366]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; negative regulation of JNK cascade [GO:0046329]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of primary amine oxidase activity [GO:1902283]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of spontaneous neurotransmitter secretion [GO:1904049]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron cellular homeostasis [GO:0070050]; norepinephrine metabolic process [GO:0042415]; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:0061734]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of dendrite extension [GO:1903861]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitochondrial fusion [GO:0010636]; positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of neurotransmitter uptake [GO:0051582]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of retrograde transport, endosome to Golgi [GO:1905281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of dopamine metabolic process [GO:0042053]; regulation of dopamine secretion [GO:0014059]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid transport [GO:0032368]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of necroptotic process [GO:0060544]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of synaptic vesicle transport [GO:1902803]; regulation protein catabolic process at presynapse [GO:0140251]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]; ubiquitin-dependent protein catabolic process [GO:0006511]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Lewy body [GO:0097413]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; ubiquitin ligase complex [GO:0000151]	actin binding [GO:0003779]; beta-catenin binding [GO:0008013]; cullin family protein binding [GO:0097602]; enzyme binding [GO:0019899]; F-box domain binding [GO:1990444]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; PDZ domain binding [GO:0030165]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; SH3 domain binding [GO:0017124]; transcription corepressor activity [GO:0003714]; tubulin binding [GO:0015631]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; zinc ion binding [GO:0008270]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Lewy body [GO:0097413]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; ubiquitin ligase complex [GO:0000151]; actin binding [GO:0003779]; beta-catenin binding [GO:0008013]; cullin family protein binding [GO:0097602]; enzyme binding [GO:0019899]; F-box domain binding [GO:1990444]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; PDZ domain binding [GO:0030165]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; SH3 domain binding [GO:0017124]; transcription corepressor activity [GO:0003714]; tubulin binding [GO:0015631]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; zinc ion binding [GO:0008270]; adult locomotory behavior [GO:0008344]; aggresome assembly [GO:0070842]; amyloid fibril formation [GO:1990000]; autophagy of mitochondrion [GO:0000422]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; cellular response to unfolded protein [GO:0034620]; central nervous system development [GO:0007417]; dopamine metabolic process [GO:0042417]; dopamine uptake involved in synaptic transmission [GO:0051583]; ERAD pathway [GO:0036503]; free ubiquitin chain polymerization [GO:0010994]; learning [GO:0007612]; macroautophagy [GO:0016236]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005]; mitochondrion to lysosome transport [GO:0099074]; mitophagy [GO:0000423]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of gene expression [GO:0010629]; negative regulation of glucokinase activity [GO:0033132]; negative regulation of insulin secretion [GO:0046676]; negative regulation of intralumenal vesicle formation [GO:1905366]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; negative regulation of JNK cascade [GO:0046329]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of primary amine oxidase activity [GO:1902283]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of spontaneous neurotransmitter secretion [GO:1904049]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron cellular homeostasis [GO:0070050]; norepinephrine metabolic process [GO:0042415]; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:0061734]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of dendrite extension [GO:1903861]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitochondrial fusion [GO:0010636]; positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of neurotransmitter uptake [GO:0051582]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of retrograde transport, endosome to Golgi [GO:1905281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of dopamine metabolic process [GO:0042053]; regulation of dopamine secretion [GO:0014059]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid transport [GO:0032368]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of necroptotic process [GO:0060544]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of synaptic vesicle transport [GO:1902803]; regulation protein catabolic process at presynapse [GO:0140251]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10319893, ECO:0000269|PubMed:16955485, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19029340, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19501131, ECO:0000269|PubMed:22082830, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24898855}. Nucleus {ECO:0000269|PubMed:16955485}. Endoplasmic reticulum {ECO:0000269|PubMed:19501131}. Mitochondrion {ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19029340, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:22082830, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24898855}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9WVS6}. Cell projection, neuron projection {ECO:0000269|PubMed:12925569}. Postsynaptic density {ECO:0000250|UniProtKB:Q9WVS6}. Presynapse {ECO:0000250|UniProtKB:Q9WVS6}. Note=Mainly localizes in the cytosol (PubMed:19029340, PubMed:19229105). Co-localizes with SYT11 in neutrites (PubMed:12925569). Co-localizes with SNCAIP in brainstem Lewy bodies (PubMed:10319893, PubMed:11431533). Translocates to dysfunctional mitochondria that have lost the mitochondrial membrane potential; recruitment to mitochondria is PINK1-dependent (PubMed:24898855, PubMed:18957282, PubMed:19966284, PubMed:23620051). Mitochondrial localization also gradually increases with cellular growth (PubMed:22082830). {ECO:0000269|PubMed:10319893, ECO:0000269|PubMed:11431533, ECO:0000269|PubMed:12925569, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19029340, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:22082830, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:24898855}.
O60264	reviewed	SMCA5_HUMAN	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)	SMARCA5 SNF2H WCRF135	Homo sapiens (Human)	1052	FUNCTION: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12434153, PubMed:28801535, PubMed:12198550, PubMed:12972596, PubMed:23911928). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}.		cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA-templated transcription initiation [GO:0006352]; heterochromatin formation [GO:0031507]; negative regulation of mitotic chromosome condensation [GO:1905213]; negative regulation of transcription by RNA polymerase I [GO:0016479]; nucleosome assembly [GO:0006334]; positive regulation of DNA replication [GO:0045740]; positive regulation of histone acetylation [GO:0035066]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of histone methylation [GO:0031062]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; rDNA heterochromatin formation [GO:0000183]; regulation of DNA methylation [GO:0044030]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	ACF complex [GO:0016590]; B-WICH complex [GO:0110016]; CHRAC [GO:0008623]; chromatin silencing complex [GO:0005677]; condensed chromosome [GO:0000793]; fibrillar center [GO:0001650]; NoRC complex [GO:0090536]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]; pericentric heterochromatin [GO:0005721]; RSF complex [GO:0031213]; site of double-strand break [GO:0035861]; WICH complex [GO:0090535]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone octamer slider activity [GO:0140751]; nucleosome binding [GO:0031491]	ACF complex [GO:0016590]; B-WICH complex [GO:0110016]; CHRAC [GO:0008623]; chromatin silencing complex [GO:0005677]; condensed chromosome [GO:0000793]; fibrillar center [GO:0001650]; NoRC complex [GO:0090536]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]; pericentric heterochromatin [GO:0005721]; RSF complex [GO:0031213]; site of double-strand break [GO:0035861]; WICH complex [GO:0090535]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone octamer slider activity [GO:0140751]; nucleosome binding [GO:0031491]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA-templated transcription initiation [GO:0006352]; heterochromatin formation [GO:0031507]; negative regulation of mitotic chromosome condensation [GO:1905213]; negative regulation of transcription by RNA polymerase I [GO:0016479]; nucleosome assembly [GO:0006334]; positive regulation of DNA replication [GO:0045740]; positive regulation of histone acetylation [GO:0035066]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of histone methylation [GO:0031062]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; rDNA heterochromatin formation [GO:0000183]; regulation of DNA methylation [GO:0044030]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:33092197}. Chromosome {ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:23911928}. Note=Localizes to mitotic chromosomes (PubMed:12972596). Co-localizes with RSF1 in the nucleus (PubMed:12972596). Co-localizes with PCNA at replication foci during S phase (PubMed:15543136). Co-localizes with BAZ1B/WSTF at replication foci during late-S phase (PubMed:15543136). Recruited to DNA damage sites following interactiuon with SIRT6 (PubMed:23911928). {ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:23911928}.
O60266	reviewed	ADCY3_HUMAN	Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3)	ADCY3 KIAA0511	Homo sapiens (Human)	1144	FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. {ECO:0000250|UniProtKB:Q8VHH7}.		acrosome reaction [GO:0007340]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; cellular response to forskolin [GO:1904322]; flagellated sperm motility [GO:0030317]; intracellular signal transduction [GO:0035556]; olfactory learning [GO:0008355]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]; single fertilization [GO:0007338]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; acrosome reaction [GO:0007340]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; cellular response to forskolin [GO:1904322]; flagellated sperm motility [GO:0030317]; intracellular signal transduction [GO:0035556]; olfactory learning [GO:0008355]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11549699}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:11549699}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8VHH7}. Golgi apparatus {ECO:0000250|UniProtKB:P21932}. Note=Also detected in the cytoplasm, close to lipid droplets. {ECO:0000269|PubMed:11549699}.
O60269	reviewed	GRIN2_HUMAN	G protein-regulated inducer of neurite outgrowth 2 (GRIN2)	GPRIN2 KIAA0514	Homo sapiens (Human)	458	FUNCTION: May be involved in neurite outgrowth. {ECO:0000269|PubMed:10480904}.		neuron projection development [GO:0031175]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; neuron projection development [GO:0031175]	
O60271	reviewed	JIP4_HUMAN	C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1)	SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6	Homo sapiens (Human)	1321	FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}.	MISCELLANEOUS: [Isoform 3]: Due to intron retention. {ECO:0000305}.	lysosome localization [GO:0032418]; negative regulation of dendrite extension [GO:1903860]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cell migration [GO:0030335]; positive regulation of neuron differentiation [GO:0045666]; retrograde transport, endosome to Golgi [GO:0042147]; striated muscle cell differentiation [GO:0051146]; vesicle-mediated transport [GO:0016192]	acrosomal vesicle [GO:0001669]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]	identical protein binding [GO:0042802]; JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; signaling receptor complex adaptor activity [GO:0030159]	acrosomal vesicle [GO:0001669]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; identical protein binding [GO:0042802]; JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; signaling receptor complex adaptor activity [GO:0030159]; lysosome localization [GO:0032418]; negative regulation of dendrite extension [GO:1903860]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cell migration [GO:0030335]; positive regulation of neuron differentiation [GO:0045666]; retrograde transport, endosome to Golgi [GO:0042147]; striated muscle cell differentiation [GO:0051146]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q58A65}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q58A65}. Lysosome membrane {ECO:0000269|PubMed:29146937}. Note=Perinuclear distribution in response to stress signals such as UV radiation. {ECO:0000250|UniProtKB:Q58A65}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:15693750}. Note=Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix. {ECO:0000269|PubMed:15693750}.
O60281	reviewed	ZN292_HUMAN	Zinc finger protein 292	ZNF292 KIAA0530	Homo sapiens (Human)	2723	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O60282	reviewed	KIF5C_HUMAN	Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1)	KIF5C KIAA0531 NKHC2	Homo sapiens (Human)	957	FUNCTION: Microtubule-associated force-producing protein that may play a role in organelle transport. Has ATPase activity (By similarity). Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). {ECO:0000250|UniProtKB:P28738, ECO:0000250|UniProtKB:P56536, ECO:0000269|PubMed:24812067}.		anterograde axonal protein transport [GO:0099641]; anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; axon guidance [GO:0007411]; intracellular mRNA localization [GO:0008298]; motor neuron axon guidance [GO:0008045]; mRNA transport [GO:0051028]; organelle organization [GO:0006996]; synaptic vesicle transport [GO:0048489]	axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; ciliary rootlet [GO:0035253]; dendrite cytoplasm [GO:0032839]; distal axon [GO:0150034]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; postsynaptic cytosol [GO:0099524]	apolipoprotein receptor binding [GO:0034190]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]	axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; ciliary rootlet [GO:0035253]; dendrite cytoplasm [GO:0032839]; distal axon [GO:0150034]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; postsynaptic cytosol [GO:0099524]; apolipoprotein receptor binding [GO:0034190]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; anterograde axonal protein transport [GO:0099641]; anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; axon guidance [GO:0007411]; intracellular mRNA localization [GO:0008298]; motor neuron axon guidance [GO:0008045]; mRNA transport [GO:0051028]; organelle organization [GO:0006996]; synaptic vesicle transport [GO:0048489]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:24812067}. Note=Abundant in distal regions of dendrites. {ECO:0000269|PubMed:24812067}.
O60284	reviewed	ST18_HUMAN	Suppression of tumorigenicity 18 protein (Zinc finger protein 387)	ST18 KIAA0535 ZNF387	Homo sapiens (Human)	1047	FUNCTION: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells. {ECO:0000250, ECO:0000269|PubMed:15489893}.		interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-6-mediated signaling pathway [GO:0070102]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	chromatin [GO:0000785]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-6-mediated signaling pathway [GO:0070102]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15489893}.
O60285	reviewed	NUAK1_HUMAN	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)	NUAK1 ARK5 KIAA0537 OMPHK1	Homo sapiens (Human)	661	FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}.		cell adhesion [GO:0007155]; cellular response to glucose starvation [GO:0042149]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; negative regulation of TOR signaling [GO:0032007]; protein phosphorylation [GO:0006468]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; regulation of cellular senescence [GO:2000772]; regulation of myosin-light-chain-phosphatase activity [GO:0035507]; regulation of signal transduction by p53 class mediator [GO:1901796]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell adhesion [GO:0007155]; cellular response to glucose starvation [GO:0042149]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; negative regulation of TOR signaling [GO:0032007]; protein phosphorylation [GO:0006468]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; regulation of cellular senescence [GO:2000772]; regulation of myosin-light-chain-phosphatase activity [GO:0035507]; regulation of signal transduction by p53 class mediator [GO:1901796]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21317932}. Cytoplasm {ECO:0000269|PubMed:21317932}.
O60291	reviewed	MGRN1_HUMAN	E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1)	MGRN1 KIAA0544 RNF156	Homo sapiens (Human)	552	FUNCTION: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}.		endosome to lysosome transport [GO:0008333]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of smoothened signaling pathway [GO:0045879]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; endosome to lysosome transport [GO:0008333]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of smoothened signaling pathway [GO:0045879]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19737927}. Note=The endosomal localization is dependent on the interaction with TSG101.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol. Cell membrane.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm, cytosol. Cell membrane.
O60292	reviewed	SI1L3_HUMAN	Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3)	SIPA1L3 KIAA0545 SPAL3	Homo sapiens (Human)	1781	FUNCTION: Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.		cytoskeleton organization [GO:0007010]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell polarity [GO:0090162]; eye development [GO:0001654]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of small GTPase mediated signal transduction [GO:0051056]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; tricellular tight junction [GO:0061689]	GTPase activator activity [GO:0005096]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; tricellular tight junction [GO:0061689]; GTPase activator activity [GO:0005096]; cytoskeleton organization [GO:0007010]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell polarity [GO:0090162]; eye development [GO:0001654]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:26231217}. Note=Detected in tricellular junctions. Colocalizes with apical F-actin. {ECO:0000269|PubMed:26231217}.
O60293	reviewed	ZC3H1_HUMAN	Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2)	ZFC3H1 CCDC131 KIAA0546 PSRC2	Homo sapiens (Human)	1989	FUNCTION: Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}.		RNA processing [GO:0006396]	exosome (RNase complex) [GO:0000178]; extracellular space [GO:0005615]; nucleus [GO:0005634]	metal ion binding [GO:0046872]	exosome (RNase complex) [GO:0000178]; extracellular space [GO:0005615]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27871484}. Note=Excluded from the nucleolus. {ECO:0000269|PubMed:27871484}.
O60294	reviewed	TYW4_HUMAN	tRNA wybutosine-synthesizing protein 4 (tRNA yW-synthesizing protein 4) (EC 2.1.1.290) (EC 2.3.1.231) (Leucine carboxyl methyltransferase 2) (tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase)	LCMT2 KIAA0547 TYW4	Homo sapiens (Human)	686	FUNCTION: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues. {ECO:0000250}.		tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; wybutosine biosynthetic process [GO:0031591]	cytoplasm [GO:0005737]	S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA methyltransferase activity [GO:0008175]	cytoplasm [GO:0005737]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA methyltransferase activity [GO:0008175]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; wybutosine biosynthetic process [GO:0031591]	
O60296	reviewed	TRAK2_HUMAN	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein)	TRAK2 ALS2CR3 KIAA0549	Homo sapiens (Human)	914	FUNCTION: May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. {ECO:0000250}.		anterograde axonal transport of mitochondrion [GO:0098957]; anterograde dendritic transport of mitochondrion [GO:0098972]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; protein targeting [GO:0006605]; vesicle transport along microtubule [GO:0047496]	axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; early endosome [GO:0005769]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GABA receptor binding [GO:0050811]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102]	axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; early endosome [GO:0005769]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; GABA receptor binding [GO:0050811]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102]; anterograde axonal transport of mitochondrion [GO:0098957]; anterograde dendritic transport of mitochondrion [GO:0098972]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; protein targeting [GO:0006605]; vesicle transport along microtubule [GO:0047496]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Early endosome {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner (By similarity). {ECO:0000250}.
O60303	reviewed	KATIP_HUMAN	Katanin-interacting protein	KATNIP KIAA0556	Homo sapiens (Human)	1618	FUNCTION: May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. {ECO:0000269|PubMed:26714646}.		cerebrospinal fluid circulation [GO:0090660]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]		cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; cerebrospinal fluid circulation [GO:0090660]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:26714646}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:26714646}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26714646}. Note=When overexpressed, localizes to the cytoplasm where it associates with acetylated alpha-tubulin. {ECO:0000269|PubMed:26714646}.
O60304	reviewed	ZN500_HUMAN	Zinc finger protein 500 (Zinc finger protein with KRAB and SCAN domains 18)	ZNF500 KIAA0557 ZKSCAN18	Homo sapiens (Human)	480	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
O60306	reviewed	AQR_HUMAN	RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160)	AQR KIAA0560	Homo sapiens (Human)	1485	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28502770, PubMed:28076346). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16949364, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.		mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]	3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. Nucleus, nucleoplasm {ECO:0000269|PubMed:16949364}. Note=Localizes to speckle-like regions of the nucleoplasm. {ECO:0000269|PubMed:16949364}.
O60307	reviewed	MAST3_HUMAN	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1)	MAST3 KIAA0561	Homo sapiens (Human)	1309			cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3U214}.
O60308	reviewed	CE104_HUMAN	Centrosomal protein of 104 kDa (Cep104)	CEP104 KIAA0562	Homo sapiens (Human)	925	FUNCTION: Required for ciliogenesis and for structural integrity at the ciliary tip. {ECO:0000269|PubMed:23970417}.			centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737]; spindle pole [GO:0000922]		centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737]; spindle pole [GO:0000922]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:23970417}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:23970417}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23970417}. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase non-ciliated cells, localizes to the distal ends of both the mother and daughter centrioles. In ciliated cells, present at the distal end of the daughter centriole, but not on the mother centriole, and at the tip of primary cilium. Localization at the ciliary tip is also observed in motile cilia. Throughout S phase, associated with both mother and daughter centrioles in each centrosome. During metaphase and telophase, present at both spindle poles. {ECO:0000269|PubMed:23970417}.
O60312	reviewed	AT10A_HUMAN	Phospholipid-transporting ATPase VA (EC 7.6.2.1) (ATPase class V type 10A) (Aminophospholipid translocase VA) (P4-ATPase flippase complex alpha subunit ATP10A)	ATP10A ATP10C ATPVA ATPVC KIAA0566	Homo sapiens (Human)	1499	FUNCTION: Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane (PubMed:25947375, PubMed:29599178, PubMed:30530492). Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking (PubMed:29599178). Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix (PubMed:29599178, PubMed:25947375). Has low flippase activity toward glucosylceramide (GlcCer) (PubMed:30530492). {ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:29599178, ECO:0000269|PubMed:30530492}.		monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]; positive regulation of membrane tubulation [GO:1903527]; regulation of cell shape [GO:0008360]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine floppase activity [GO:0090554]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine floppase activity [GO:0090554]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]; positive regulation of membrane tubulation [GO:1903527]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:30530492}; Multi-pass membrane protein {ECO:0000269|PubMed:21914794}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25947375}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.
O60313	reviewed	OPA1_HUMAN	Dynamin-like 120 kDa protein, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like 120 kDa protein, form S1]	OPA1 KIAA0567	Homo sapiens (Human)	960	FUNCTION: Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (PubMed:20974897, PubMed:18158317). {ECO:0000250|UniProtKB:P58281, ECO:0000269|PubMed:16778770, ECO:0000269|PubMed:17709429, ECO:0000269|PubMed:18158317, ECO:0000269|PubMed:20185555, ECO:0000269|PubMed:20974897, ECO:0000269|PubMed:24616225, ECO:0000269|PubMed:28746876}.; FUNCTION: [Dynamin-like 120 kDa protein, form S1]: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion. {ECO:0000269|PubMed:20038677}.; FUNCTION: Isoforms that contain the alternative exon 4b (present in isoform 4 and isoform 5) are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. {ECO:0000269|PubMed:20974897}.	MISCELLANEOUS: [Isoform 4]: Contains the alternative exon 4b that is important for mitochondrial genome maintenance. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Contains the alternative exon 4b that is important for mitochondrial genome maintenance. {ECO:0000305}.	apoptotic process [GO:0006915]; axonal transport of mitochondrion [GO:0019896]; cellular senescence [GO:0090398]; GTP metabolic process [GO:0046039]; inner mitochondrial membrane organization [GO:0007007]; membrane tubulation [GO:0097749]; mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; mitochondrial genome maintenance [GO:0000002]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; neural tube closure [GO:0001843]; protein complex oligomerization [GO:0051259]; visual perception [GO:0007601]	axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	cardiolipin binding [GO:1901612]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; phosphatidic acid binding [GO:0070300]	axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; cardiolipin binding [GO:1901612]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; phosphatidic acid binding [GO:0070300]; apoptotic process [GO:0006915]; axonal transport of mitochondrion [GO:0019896]; cellular senescence [GO:0090398]; GTP metabolic process [GO:0046039]; inner mitochondrial membrane organization [GO:0007007]; membrane tubulation [GO:0097749]; mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; mitochondrial genome maintenance [GO:0000002]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; neural tube closure [GO:0001843]; protein complex oligomerization [GO:0051259]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11017079, ECO:0000269|PubMed:16778770, ECO:0000269|PubMed:20974897, ECO:0000269|PubMed:28746876}; Single-pass membrane protein {ECO:0000255}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P58281}. Mitochondrion membrane {ECO:0000269|PubMed:24616225}. Note=Detected at contact sites between endoplasmic reticulum and mitochondrion membranes. {ECO:0000269|PubMed:24616225}.
O60315	reviewed	ZEB2_HUMAN	Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b)	ZEB2 KIAA0569 SIP1 ZFHX1B ZFX1B HRIHFB2411	Homo sapiens (Human)	1214	FUNCTION: Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}.		anatomical structure development [GO:0048856]; astrocyte activation [GO:0048143]; developmental pigmentation [GO:0048066]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; fibroblast activation [GO:0072537]; melanocyte migration [GO:0097324]; myofibroblast differentiation [GO:0036446]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of myofibroblast contraction [GO:1904330]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; pyroptosis [GO:0070269]; regulation of blood-brain barrier permeability [GO:1905603]; regulation of melanosome organization [GO:1903056]; regulation of myofibroblast cell apoptotic process [GO:1904520]; regulation of transcription by RNA polymerase II [GO:0006357]; response to oxygen-glucose deprivation [GO:0090649]; stress fiber assembly [GO:0043149]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; phosphatase regulator activity [GO:0019208]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; phosphatase regulator activity [GO:0019208]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure development [GO:0048856]; astrocyte activation [GO:0048143]; developmental pigmentation [GO:0048066]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; fibroblast activation [GO:0072537]; melanocyte migration [GO:0097324]; myofibroblast differentiation [GO:0036446]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of myofibroblast contraction [GO:1904330]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; pyroptosis [GO:0070269]; regulation of blood-brain barrier permeability [GO:1905603]; regulation of melanosome organization [GO:1903056]; regulation of myofibroblast cell apoptotic process [GO:1904520]; regulation of transcription by RNA polymerase II [GO:0006357]; response to oxygen-glucose deprivation [GO:0090649]; stress fiber assembly [GO:0043149]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:9853615}. Chromosome {ECO:0000269|PubMed:20516212}.
O60318	reviewed	GANP_HUMAN	Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase)	MCM3AP GANP KIAA0572 MAP80	Homo sapiens (Human)	1980	FUNCTION: [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:23591820, PubMed:22307388). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}.	MISCELLANEOUS: [Isoform MCM3AP]: Produced via an alternative promoter within an intron of GANP. MCM3AP promoter elements are poorly conserved in mice, suggesting that the regulation of MCM3AP may be human specific. {ECO:0000269|PubMed:21195085}.	mRNA export from nucleus [GO:0006406]; nucleosome organization [GO:0034728]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]; somatic hypermutation of immunoglobulin genes [GO:0016446]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex 2 [GO:0070390]	chromatin binding [GO:0003682]; histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; histone H3 acetyltransferase activity [GO:0010484]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex 2 [GO:0070390]; chromatin binding [GO:0003682]; histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; histone H3 acetyltransferase activity [GO:0010484]; nucleic acid binding [GO:0003676]; mRNA export from nucleus [GO:0006406]; nucleosome organization [GO:0034728]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]; somatic hypermutation of immunoglobulin genes [GO:0016446]	SUBCELLULAR LOCATION: [Isoform GANP]: Nucleus envelope {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:21195085, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:28633435}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20005110}. Chromosome {ECO:0000269|PubMed:23652018}. Note=Predominantly located at the nuclear envelope, facing the nucleus interior (PubMed:20005110, PubMed:21195085, PubMed:23591820). Localization at the nuclear pore complex requires NUP153, TPR and ALYREF/ALY (PubMed:23591820, PubMed:22307388). Also found associated with chromatin (PubMed:23652018). In B-cells, targeted to the immunoglobulin variable region genes (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:21195085, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; SUBCELLULAR LOCATION: [Isoform MCM3AP]: Cytoplasm {ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:21195085}. Nucleus {ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:21195085}. Note=Translocates into the nucleus in the presence of MCM3 (PubMed:12226073). Associates with chromatin possibly through interaction with MCM3 (PubMed:12226073). {ECO:0000269|PubMed:12226073}.
O60331	reviewed	PI51C_HUMAN	Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma)	PIP5K1C KIAA0589	Homo sapiens (Human)	668	FUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:12422219, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed:12847086). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:17261850). Participates in cell junction assembly (PubMed:17261850). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed:17261850). Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed:12422219). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed:12422219). Required for uropodium formation and retraction of the cell rear during directed migration (By similarity). Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937). Negative regulator of T-cell activation and adhesion (By similarity). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (By similarity). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity). {ECO:0000250|UniProtKB:O70161, ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:12422219, ECO:0000269|PubMed:12847086, ECO:0000269|PubMed:17261850, ECO:0000269|PubMed:17635937, ECO:0000269|PubMed:22942276, ECO:0000305|PubMed:19889969}.		actin cytoskeleton organization [GO:0030036]; adherens junction assembly [GO:0034333]; cell-cell adhesion [GO:0098609]; clathrin-dependent endocytosis [GO:0072583]; membrane organization [GO:0061024]; neutrophil chemotaxis [GO:0030593]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]	adherens junction [GO:0005912]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; ruffle membrane [GO:0032587]; uropod [GO:0001931]	1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524]; phosphatidylinositol kinase activity [GO:0052742]	adherens junction [GO:0005912]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; ruffle membrane [GO:0032587]; uropod [GO:0001931]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524]; phosphatidylinositol kinase activity [GO:0052742]; actin cytoskeleton organization [GO:0030036]; adherens junction assembly [GO:0034333]; cell-cell adhesion [GO:0098609]; clathrin-dependent endocytosis [GO:0072583]; membrane organization [GO:0061024]; neutrophil chemotaxis [GO:0030593]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q5I6B8}. Endomembrane system {ECO:0000250|UniProtKB:Q5I6B8}. Cytoplasm {ECO:0000250|UniProtKB:O70161}. Cell junction, focal adhesion {ECO:0000269|PubMed:12422219}. Cell junction, adherens junction {ECO:0000269|PubMed:17261850}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q5I6B8}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70161}. Cell projection, uropodium {ECO:0000250|UniProtKB:O70161}. Note=Detected in plasma membrane invaginations. Isoform 3 is detected in intracellular vesicle-like structures.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.
O60333	reviewed	KIF1B_HUMAN	Kinesin-like protein KIF1B (Klp)	KIF1B KIAA0591 KIAA1448	Homo sapiens (Human)	1816	FUNCTION: Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis. {ECO:0000269|PubMed:18334619}.; FUNCTION: Isoform 1 mediates the transport of synaptic vesicles in neuronal cells. {ECO:0000250|UniProtKB:O88658}.		anterograde axonal transport [GO:0008089]; apoptotic process [GO:0006915]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; neuromuscular synaptic transmission [GO:0007274]; neuron-neuron synaptic transmission [GO:0007270]; vesicle-mediated transport [GO:0016192]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; synaptic vesicle [GO:0008021]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; synaptic vesicle [GO:0008021]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]; anterograde axonal transport [GO:0008089]; apoptotic process [GO:0006915]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; neuromuscular synaptic transmission [GO:0007274]; neuron-neuron synaptic transmission [GO:0007270]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Mitochondrion {ECO:0000269|PubMed:16225668}. Cell projection, axon {ECO:0000250|UniProtKB:Q60575}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:O88658}.
O60336	reviewed	MABP1_HUMAN	Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1)	MAPKBP1 JNKBP1 KIAA0596	Homo sapiens (Human)	1514	FUNCTION: Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}.		negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of defense response to bacterium [GO:1900425]; negative regulation of interleukin-8 production [GO:0032717]; positive regulation of JNK cascade [GO:0046330]	cytoplasm [GO:0005737]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		cytoplasm [GO:0005737]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of defense response to bacterium [GO:1900425]; negative regulation of interleukin-8 production [GO:0032717]; positive regulation of JNK cascade [GO:0046330]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22700971, ECO:0000269|PubMed:28089251}. Nucleus {ECO:0000269|PubMed:22700971}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28089251}. Note=Not detected in the cilium. Localized around the poles of the mitotic spindle from prophase to anaphase in mitotic cells. {ECO:0000269|PubMed:28089251}.
O60337	reviewed	MARH6_HUMAN	E3 ubiquitin-protein ligase MARCHF6 (EC 2.3.2.27) (Doa10 homolog) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) (Protein TEB-4) (RING finger protein 176) (RING-type E3 ubiquitin transferase MARCHF6)	MARCHF6 KIAA0597 MARCH6 RNF176 TEB4	Homo sapiens (Human)	910	FUNCTION: E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation (PubMed:15673284). Promotes ubiquitination of DIO2, leading to its degradation (PubMed:19651899). Promotes ubiquitination of SQLE, leading to its degradation (PubMed:24449766). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 (PubMed:15673284). {ECO:0000269|PubMed:15673284, ECO:0000269|PubMed:19651899, ECO:0000269|PubMed:24449766}.		ERAD pathway [GO:0036503]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER ubiquitin ligase complex [GO:0000835]; membrane [GO:0016020]	enzyme binding [GO:0019899]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER ubiquitin ligase complex [GO:0000835]; membrane [GO:0016020]; enzyme binding [GO:0019899]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; zinc ion binding [GO:0008270]; ERAD pathway [GO:0036503]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15673284}; Multi-pass membrane protein {ECO:0000269|PubMed:15673284}.
O60341	reviewed	KDM1A_HUMAN	Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)	KDM1A AOF2 KDM1 KIAA0601 LSD1	Homo sapiens (Human)	852	FUNCTION: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16140033, PubMed:16079794, PubMed:16079795, PubMed:16223729). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16140033, PubMed:16079794, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). {ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:15620353, ECO:0000269|PubMed:15811342, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:16140033, ECO:0000269|PubMed:16223729, ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:29358331, ECO:0000269|PubMed:29691401}.		alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to cAMP [GO:0071320]; cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; cerebral cortex development [GO:0021987]; DNA repair-dependent chromatin remodeling [GO:0140861]; guanine metabolic process [GO:0046098]; muscle cell development [GO:0055001]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron maturation [GO:0042551]; positive regulation of cell size [GO:0045793]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein demethylation [GO:0006482]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of DNA methylation-dependent heterochromatin formation [GO:0090308]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of protein localization [GO:0032880]; regulation of transcription by RNA polymerase II [GO:0006357]; response to fungicide [GO:0060992]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; DNA repair complex [GO:1990391]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; demethylase activity [GO:0032451]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; flavin adenine dinucleotide binding [GO:0050660]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K9 demethylase activity [GO:0032454]; identical protein binding [GO:0042802]; MRF binding [GO:0043426]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; oxidoreductase activity [GO:0016491]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; telomeric repeat-containing RNA binding [GO:0061752]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; DNA repair complex [GO:1990391]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; demethylase activity [GO:0032451]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; flavin adenine dinucleotide binding [GO:0050660]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K9 demethylase activity [GO:0032454]; identical protein binding [GO:0042802]; MRF binding [GO:0043426]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; oxidoreductase activity [GO:0016491]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; telomeric repeat-containing RNA binding [GO:0061752]; transcription coactivator activity [GO:0003713]; alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to cAMP [GO:0071320]; cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; cerebral cortex development [GO:0021987]; DNA repair-dependent chromatin remodeling [GO:0140861]; guanine metabolic process [GO:0046098]; muscle cell development [GO:0055001]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron maturation [GO:0042551]; positive regulation of cell size [GO:0045793]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein demethylation [GO:0006482]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of DNA methylation-dependent heterochromatin formation [GO:0090308]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of protein localization [GO:0032880]; regulation of transcription by RNA polymerase II [GO:0006357]; response to fungicide [GO:0060992]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11102443, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:33980486}.
O60343	reviewed	TBCD4_HUMAN	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)	TBC1D4 AS160 KIAA0603	Homo sapiens (Human)	1298	FUNCTION: May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}.		cellular response to insulin stimulus [GO:0032869]; negative regulation of vesicle fusion [GO:0031339]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; vesicle [GO:0031982]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; vesicle [GO:0031982]; GTPase activator activity [GO:0005096]; cellular response to insulin stimulus [GO:0032869]; negative regulation of vesicle fusion [GO:0031339]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18771725}. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
O60346	reviewed	PHLP1_HUMAN	PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)	PHLPP1 KIAA0606 PHLPP PLEKHE1 SCOP	Homo sapiens (Human)	1717	FUNCTION: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}.		apoptotic process [GO:0006915]; entrainment of circadian clock [GO:0009649]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; regulation of apoptotic process [GO:0042981]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408]; regulation of p38MAPK cascade [GO:1900744]; regulation of T cell anergy [GO:0002667]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; apoptotic process [GO:0006915]; entrainment of circadian clock [GO:0009649]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; regulation of apoptotic process [GO:0042981]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408]; regulation of p38MAPK cascade [GO:1900744]; regulation of T cell anergy [GO:0002667]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated at the lateral membrane of epithelial cells.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:21804599}.
O60353	reviewed	FZD6_HUMAN	Frizzled-6 (Fz-6) (hFz6)	FZD6	Homo sapiens (Human)	706	FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}.		canonical Wnt signaling pathway [GO:0060070]; cell proliferation in midbrain [GO:0033278]; embryonic nail plate morphogenesis [GO:0035880]; establishment of body hair planar orientation [GO:0048105]; hair follicle development [GO:0001942]; inner ear morphogenesis [GO:0042472]; midbrain morphogenesis [GO:1904693]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; neural tube closure [GO:0001843]; non-canonical Wnt signaling pathway [GO:0035567]; platelet activation [GO:0030168]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; canonical Wnt signaling pathway [GO:0060070]; cell proliferation in midbrain [GO:0033278]; embryonic nail plate morphogenesis [GO:0035880]; establishment of body hair planar orientation [GO:0048105]; hair follicle development [GO:0001942]; inner ear morphogenesis [GO:0042472]; midbrain morphogenesis [GO:1904693]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; neural tube closure [GO:0001843]; non-canonical Wnt signaling pathway [GO:0035567]; platelet activation [GO:0030168]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:Q61089}. Apical cell membrane; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with FZD3 at the apical face of cells (By similarity). Localizes to the endoplasmic reticulum membrane in the presence of LMBR1L (By similarity). {ECO:0000250|UniProtKB:Q61089}.
O60356	reviewed	NUPR1_HUMAN	Nuclear protein 1 (Candidate of metastasis 1) (Protein p8)	NUPR1 COM1	Homo sapiens (Human)	82	FUNCTION: Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:16478804, PubMed:19650074, PubMed:16300740, PubMed:19723804, PubMed:11056169, PubMed:22858377, PubMed:11940591, PubMed:18690848, PubMed:22565310, PubMed:20181828, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). {ECO:0000250|UniProtKB:O54842, ECO:0000250|UniProtKB:Q9WTK0, ECO:0000269|PubMed:11056169, ECO:0000269|PubMed:11940591, ECO:0000269|PubMed:16300740, ECO:0000269|PubMed:16478804, ECO:0000269|PubMed:18690848, ECO:0000269|PubMed:19650074, ECO:0000269|PubMed:19723804, ECO:0000269|PubMed:20181828, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377, ECO:0000269|PubMed:30451898}.	MISCELLANEOUS: Mediates resistance to anticancer drugs, namely taxol, doxorubicin, gemcitabine. {ECO:0000269|PubMed:18690848, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377}.	acute inflammatory response [GO:0002526]; fibroblast apoptotic process [GO:0044346]; fibroblast proliferation [GO:0048144]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of autophagy [GO:0010507]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of glycolytic process [GO:0045820]; negative regulation of programmed necrotic cell death [GO:0062099]; negative regulation of type B pancreatic cell proliferation [GO:1904691]; positive regulation of cell cycle [GO:0045787]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein modification process [GO:0031401]; protein-containing complex assembly [GO:0065003]; regulation of autophagy [GO:0010506]; regulation of female gonad development [GO:2000194]; regulation of response to endoplasmic reticulum stress [GO:1905897]; response to toxic substance [GO:0009636]; skeletal muscle cell differentiation [GO:0035914]	cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-DNA complex [GO:0032993]	acetyltransferase activator activity [GO:0010698]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-DNA complex [GO:0032993]; acetyltransferase activator activity [GO:0010698]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]; acute inflammatory response [GO:0002526]; fibroblast apoptotic process [GO:0044346]; fibroblast proliferation [GO:0048144]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of autophagy [GO:0010507]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of glycolytic process [GO:0045820]; negative regulation of programmed necrotic cell death [GO:0062099]; negative regulation of type B pancreatic cell proliferation [GO:1904691]; positive regulation of cell cycle [GO:0045787]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein modification process [GO:0031401]; protein-containing complex assembly [GO:0065003]; regulation of autophagy [GO:0010506]; regulation of female gonad development [GO:2000194]; regulation of response to endoplasmic reticulum stress [GO:1905897]; response to toxic substance [GO:0009636]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10092851, ECO:0000269|PubMed:16300740}. Cytoplasm {ECO:0000269|PubMed:16300740}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16300740}.
O60359	reviewed	CCG3_HUMAN	Voltage-dependent calcium channel gamma-3 subunit (Neuronal voltage-gated calcium channel gamma-3 subunit) (Transmembrane AMPAR regulatory protein gamma-3) (TARP gamma-3)	CACNG3	Homo sapiens (Human)	315	FUNCTION: Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000250|UniProtKB:Q8VHX0}.		calcium ion transport [GO:0006816]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; protein localization [GO:0008104]; protein targeting [GO:0006605]; regulation of AMPA receptor activity [GO:2000311]; regulation of monoatomic ion transmembrane transport [GO:0034765]; transmission of nerve impulse [GO:0019226]	AMPA glutamate receptor complex [GO:0032281]; dendrite [GO:0030425]; endocytic vesicle membrane [GO:0030666]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; somatodendritic compartment [GO:0036477]; voltage-gated calcium channel complex [GO:0005891]	channel regulator activity [GO:0016247]; ionotropic glutamate receptor binding [GO:0035255]; PDZ domain binding [GO:0030165]; voltage-gated calcium channel activity [GO:0005245]	AMPA glutamate receptor complex [GO:0032281]; dendrite [GO:0030425]; endocytic vesicle membrane [GO:0030666]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; somatodendritic compartment [GO:0036477]; voltage-gated calcium channel complex [GO:0005891]; channel regulator activity [GO:0016247]; ionotropic glutamate receptor binding [GO:0035255]; PDZ domain binding [GO:0030165]; voltage-gated calcium channel activity [GO:0005245]; calcium ion transport [GO:0006816]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; protein localization [GO:0008104]; protein targeting [GO:0006605]; regulation of AMPA receptor activity [GO:2000311]; regulation of monoatomic ion transmembrane transport [GO:0034765]; transmission of nerve impulse [GO:0019226]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Displays a somatodendritic localization and is excluded from axons in neurons. {ECO:0000250|UniProtKB:Q9JJV5}.
O60381	reviewed	HBP1_HUMAN	HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1)	HBP1	Homo sapiens (Human)	514	FUNCTION: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. {ECO:0000269|PubMed:10562551, ECO:0000269|PubMed:10958660, ECO:0000269|PubMed:11500377}.		regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:10562551}.
O60383	reviewed	GDF9_HUMAN	Growth/differentiation factor 9 (GDF-9)	GDF9	Homo sapiens (Human)	454	FUNCTION: Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. {ECO:0000269|PubMed:12050262, ECO:0000269|PubMed:19366876, ECO:0000269|PubMed:20660033, ECO:0000269|PubMed:21632818, ECO:0000269|PubMed:21829661}.	MISCELLANEOUS: Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.	female gamete generation [GO:0007292]; negative regulation of cell growth [GO:0030308]; oocyte growth [GO:0001555]; positive regulation of cell population proliferation [GO:0008284]; regulation of progesterone secretion [GO:2000870]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; female gamete generation [GO:0007292]; negative regulation of cell growth [GO:0030308]; oocyte growth [GO:0001555]; positive regulation of cell population proliferation [GO:0008284]; regulation of progesterone secretion [GO:2000870]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
O60391	reviewed	NMD3B_HUMAN	Glutamate receptor ionotropic, NMDA 3B (GluN3B) (N-methyl-D-aspartate receptor subtype 3B) (NMDAR3B) (NR3B)	GRIN3B	Homo sapiens (Human)	1043	FUNCTION: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.		ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; protein insertion into membrane [GO:0051205]; regulation of calcium ion transport [GO:0051924]; synaptic transmission, glutamatergic [GO:0035249]	neuronal cell body [GO:0043025]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	calcium channel activity [GO:0005262]; glutamate receptor activity [GO:0008066]; glycine binding [GO:0016594]; ionotropic glutamate receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; monoatomic cation channel activity [GO:0005261]; neurotransmitter binding [GO:0042165]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	neuronal cell body [GO:0043025]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; calcium channel activity [GO:0005262]; glutamate receptor activity [GO:0008066]; glycine binding [GO:0016594]; ionotropic glutamate receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; monoatomic cation channel activity [GO:0005261]; neurotransmitter binding [GO:0042165]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; protein insertion into membrane [GO:0051205]; regulation of calcium ion transport [GO:0051924]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane. {ECO:0000250}.
O60393	reviewed	NOBOX_HUMAN	Homeobox protein NOBOX	NOBOX	Homo sapiens (Human)	691	FUNCTION: Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. {ECO:0000269|PubMed:25514101, ECO:0000269|PubMed:27798098}.		oogenesis [GO:0048477]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; oogenesis [GO:0048477]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:27798098}.
O60423	reviewed	AT8B3_HUMAN	Phospholipid-transporting ATPase IK (EC 7.6.2.1) (ATPase class I type 8B member 3)	ATP8B3 ATP1K FOS37502_2	Homo sapiens (Human)	1300	FUNCTION: P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida. {ECO:0000250|UniProtKB:Q6UQ17}.	MISCELLANEOUS: Association with flippase complex beta subunits TMEM30A and TMEM30A has not been detected, neither did their coexpression change the localization in ER. {ECO:0000305|PubMed:20947505}.	binding of sperm to zona pellucida [GO:0007339]; establishment of localization in cell [GO:0051649]; Golgi organization [GO:0007030]; phospholipid translocation [GO:0045332]	acrosomal membrane [GO:0002080]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylserine floppase activity [GO:0090556]	acrosomal membrane [GO:0002080]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylserine floppase activity [GO:0090556]; binding of sperm to zona pellucida [GO:0007339]; establishment of localization in cell [GO:0051649]; Golgi organization [GO:0007030]; phospholipid translocation [GO:0045332]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q6UQ17}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20947505}; Multi-pass membrane protein {ECO:0000255}.
O60427	reviewed	FADS1_HUMAN	Acyl-CoA (8-3)-desaturase (EC 1.14.19.44) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) (Fatty acid desaturase 1)	FADS1 FADSD5	Homo sapiens (Human)	444	FUNCTION: [Isoform 1]: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:10601301, PubMed:10769175). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity). {ECO:0000250|UniProtKB:Q920L1, ECO:0000250|UniProtKB:Q920R3, ECO:0000269|PubMed:10601301, ECO:0000269|PubMed:10769175}.; FUNCTION: [Isoform 2]: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity. {ECO:0000250|UniProtKB:A4UVI1}.		alpha-linolenic acid metabolic process [GO:0036109]; cell-cell signaling [GO:0007267]; cellular response to starvation [GO:0009267]; icosanoid biosynthetic process [GO:0046456]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; long-chain fatty acid biosynthetic process [GO:0042759]; phospholipid biosynthetic process [GO:0008654]; regulation of cell differentiation [GO:0045595]; regulation of DNA-templated transcription [GO:0006355]; unsaturated fatty acid biosynthetic process [GO:0006636]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]	acyl-CoA delta5-desaturase activity [GO:0062076]; C-5 sterol desaturase activity [GO:0000248]; linoleoyl-CoA desaturase activity [GO:0016213]; omega-6 fatty acid desaturase activity [GO:0045485]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; acyl-CoA delta5-desaturase activity [GO:0062076]; C-5 sterol desaturase activity [GO:0000248]; linoleoyl-CoA desaturase activity [GO:0016213]; omega-6 fatty acid desaturase activity [GO:0045485]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]; alpha-linolenic acid metabolic process [GO:0036109]; cell-cell signaling [GO:0007267]; cellular response to starvation [GO:0009267]; icosanoid biosynthetic process [GO:0046456]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; long-chain fatty acid biosynthetic process [GO:0042759]; phospholipid biosynthetic process [GO:0008654]; regulation of cell differentiation [GO:0045595]; regulation of DNA-templated transcription [GO:0006355]; unsaturated fatty acid biosynthetic process [GO:0006636]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A4UVI1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A4UVI1}. Mitochondrion {ECO:0000269|PubMed:22619218}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A4UVI1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A4UVI1}.
O60437	reviewed	PEPL_HUMAN	Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)	PPL KIAA0568	Homo sapiens (Human)	1756	FUNCTION: Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}.		intermediate filament cytoskeleton organization [GO:0045104]; keratinization [GO:0031424]; response to mechanical stimulus [GO:0009612]; wound healing [GO:0042060]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; intermediate filament cytoskeleton organization [GO:0045104]; keratinization [GO:0031424]; response to mechanical stimulus [GO:0009612]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell junction, desmosome {ECO:0000269|PubMed:9412476}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9412476}. Cell membrane {ECO:0000250|UniProtKB:Q9R269}. Cytoplasm {ECO:0000250|UniProtKB:Q9R269}.
O60443	reviewed	GSDME_HUMAN	Gasdermin-E (Inversely correlated with estrogen receptor expression 1) (ICERE-1) (Non-syndromic hearing impairment protein 5) [Cleaved into: Gasdermin-E, N-terminal (GSDME-NT); Gasdermin-E, C-terminal (GSDME-CT)]	GSDME DFNA5 ICERE1	Homo sapiens (Human)	496	FUNCTION: [Gasdermin-E]: Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis (PubMed:27281216, PubMed:28459430, PubMed:33852854, PubMed:35594856). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:28459430). {ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:28459430, ECO:0000269|PubMed:33852854, ECO:0000269|PubMed:35594856}.; FUNCTION: [Gasdermin-E, N-terminal]: Pore-forming protein produced by cleavage by CASP3 or granzyme B (GZMB), which converts non-inflammatory apoptosis to pyroptosis or promotes granzyme-mediated pyroptosis, respectively (PubMed:27281216, PubMed:28459430, PubMed:32188940, PubMed:33852854, PubMed:35594856). After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukins (IL1B and IL16) and triggering pyroptosis (PubMed:28459430, PubMed:32188940, PubMed:33852854, PubMed:35594856). Binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:28459430). Cleavage by CASP3 switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis (PubMed:27281216, PubMed:28459430, PubMed:32188940). Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents (PubMed:28045099). Exhibits bactericidal activity (PubMed:27281216). Cleavage by GZMB promotes tumor suppressor activity by triggering robust anti-tumor immunity (PubMed:21522185, PubMed:32188940). Suppresses tumors by mediating granzyme-mediated pyroptosis in target cells of natural killer (NK) cells: cleavage by granzyme B (GZMB), delivered to target cells from NK-cells, triggers pyroptosis of tumor cells and tumor suppression (PubMed:32188940, PubMed:31953257). May play a role in the p53/TP53-regulated cellular response to DNA damage (PubMed:16897187). {ECO:0000269|PubMed:16897187, ECO:0000269|PubMed:21522185, ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:28045099, ECO:0000269|PubMed:28459430, ECO:0000269|PubMed:31953257, ECO:0000269|PubMed:32188940, ECO:0000269|PubMed:33852854, ECO:0000269|PubMed:35594856}.; FUNCTION: [Gasdermin-E, N-terminal]: (Microbial infection) Pore-forming protein, which promotes maternal placental pyroptosis in response to Zika virus infection, contributing to adverse fetal outcomes. {ECO:0000269|PubMed:35972780}.		cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; inner ear auditory receptor cell differentiation [GO:0042491]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of immune response to tumor cell [GO:0002839]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of MAPK cascade [GO:0043410]; programmed cell death [GO:0012501]; pyroptosis [GO:0070269]; sensory perception of sound [GO:0007605]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cardiolipin binding [GO:1901612]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; wide pore channel activity [GO:0022829]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cardiolipin binding [GO:1901612]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; wide pore channel activity [GO:0022829]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; inner ear auditory receptor cell differentiation [GO:0042491]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of immune response to tumor cell [GO:0002839]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of MAPK cascade [GO:0043410]; programmed cell death [GO:0012501]; pyroptosis [GO:0070269]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: [Gasdermin-E, N-terminal]: Cell membrane {ECO:0000269|PubMed:28045099, ECO:0000269|PubMed:28459430}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.; SUBCELLULAR LOCATION: [Gasdermin-E]: Cytoplasm, cytosol {ECO:0000269|PubMed:28045099}.
O60447	reviewed	EVI5_HUMAN	Ecotropic viral integration site 5 protein homolog (EVI-5) (Neuroblastoma stage 4S gene protein)	EVI5 NB4S	Homo sapiens (Human)	810	FUNCTION: Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. {ECO:0000269|PubMed:16439210}.	MISCELLANEOUS: Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities.	cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of GTPase activity [GO:0043547]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; spindle [GO:0005819]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; spindle [GO:0005819]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of GTPase activity [GO:0043547]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.
O60449	reviewed	LY75_HUMAN	Lymphocyte antigen 75 (Ly-75) (C-type lectin domain family 13 member B) (DEC-205) (gp200-MR6) (CD antigen CD205)	LY75 CD205 CLEC13B	Homo sapiens (Human)	1722	FUNCTION: Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. {ECO:0000250}.	MISCELLANEOUS: Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.; MISCELLANEOUS: [Isoform 2]: Produced by intergenic splicing of LY75 and CD302. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by intergenic splicing of LY75 and CD302. {ECO:0000305}.	endocytosis [GO:0006897]; immune response [GO:0006955]; inflammatory response [GO:0006954]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023]; endocytosis [GO:0006897]; immune response [GO:0006955]; inflammatory response [GO:0006954]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
O60462	reviewed	NRP2_HUMAN	Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2)	NRP2 VEGF165R2	Homo sapiens (Human)	931	FUNCTION: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.; FUNCTION: (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. {ECO:0000269|PubMed:30057110}.		angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to leukemia inhibitory factor [GO:1990830]; dorsal root ganglion morphogenesis [GO:1904835]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative chemotaxis [GO:0050919]; nerve development [GO:0021675]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of postsynapse organization [GO:0099175]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sensory neuron axon guidance [GO:0097374]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; ventral trunk neural crest cell migration [GO:0036486]; vestibulocochlear nerve structural organization [GO:0021649]	axon [GO:0030424]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; semaphorin receptor complex [GO:0002116]	cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; semaphorin receptor activity [GO:0017154]; signaling receptor activity [GO:0038023]; vascular endothelial growth factor receptor activity [GO:0005021]	axon [GO:0030424]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; semaphorin receptor complex [GO:0002116]; cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; semaphorin receptor activity [GO:0017154]; signaling receptor activity [GO:0038023]; vascular endothelial growth factor receptor activity [GO:0005021]; angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to leukemia inhibitory factor [GO:1990830]; dorsal root ganglion morphogenesis [GO:1904835]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative chemotaxis [GO:0050919]; nerve development [GO:0021675]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of postsynapse organization [GO:0099175]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sensory neuron axon guidance [GO:0097374]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; ventral trunk neural crest cell migration [GO:0036486]; vestibulocochlear nerve structural organization [GO:0021649]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11112349}; Single-pass type I membrane protein {ECO:0000269|PubMed:11112349}.; SUBCELLULAR LOCATION: [Isoform s9]: Secreted {ECO:0000269|PubMed:11112349}.
O60469	reviewed	DSCAM_HUMAN	Cell adhesion molecule DSCAM (CHD2) (Down syndrome cell adhesion molecule)	DSCAM	Homo sapiens (Human)	2012	FUNCTION: Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). {ECO:0000250|UniProtKB:F1NY98, ECO:0000250|UniProtKB:Q9ERC8, ECO:0000269|PubMed:10925149, ECO:0000269|PubMed:18585357, ECO:0000269|PubMed:19196994}.		axon guidance [GO:0007411]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cell adhesion [GO:0007155]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; negative regulation of cell adhesion [GO:0007162]; nervous system development [GO:0007399]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of phosphorylation [GO:0042327]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416]	axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]	cell-cell adhesion mediator activity [GO:0098632]; netrin receptor binding [GO:1990890]; protein tyrosine kinase binding [GO:1990782]	axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; cell-cell adhesion mediator activity [GO:0098632]; netrin receptor binding [GO:1990890]; protein tyrosine kinase binding [GO:1990782]; axon guidance [GO:0007411]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cell adhesion [GO:0007155]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; negative regulation of cell adhesion [GO:0007162]; nervous system development [GO:0007399]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of phosphorylation [GO:0042327]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: [Isoform Short]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane {ECO:0000250|UniProtKB:Q9ERC8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9ERC8}. Cell projection, axon {ECO:0000250|UniProtKB:Q9ERC8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9ERC8}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9ERC8}. Synapse {ECO:0000250|UniProtKB:F1NY98}. Note=Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. {ECO:0000250|UniProtKB:Q9ERC8}.
O60476	reviewed	MA1A2_HUMAN	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Mannosidase alpha class 1A member 2) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB)	MAN1A2 MAN1B	Homo sapiens (Human)	641	FUNCTION: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).		carbohydrate metabolic process [GO:0005975]; lung alveolus development [GO:0048286]; N-glycan processing [GO:0006491]; respiratory gaseous exchange by respiratory system [GO:0007585]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]; carbohydrate metabolic process [GO:0005975]; lung alveolus development [GO:0048286]; N-glycan processing [GO:0006491]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein.
O60477	reviewed	BRNP1_HUMAN	BMP/retinoic acid-inducible neural-specific protein 1 (Deleted in bladder cancer protein 1)	BRINP1 DBC1 DBCCR1 FAM5A IB3089A	Homo sapiens (Human)	761	FUNCTION: Plays a role in neurogenesis and brain development (By similarity). May suppress cell cycle progression in postmitotic neurons by inhibiting G1/S transition (PubMed:11420708). {ECO:0000250|UniProtKB:Q920P3, ECO:0000269|PubMed:11420708}.	MISCELLANEOUS: Silenced by methylation in 50% of bladder cancer cell lines.	behavioral fear response [GO:0001662]; cell cycle [GO:0007049]; cellular response to retinoic acid [GO:0071300]; central nervous system neuron development [GO:0021954]; exploration behavior [GO:0035640]; maternal behavior [GO:0042711]; negative regulation of cell cycle [GO:0045786]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of neurogenesis [GO:0050768]; positive regulation of neuron differentiation [GO:0045666]; short-term memory [GO:0007614]; social behavior [GO:0035176]; vocalization behavior [GO:0071625]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]		cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; behavioral fear response [GO:0001662]; cell cycle [GO:0007049]; cellular response to retinoic acid [GO:0071300]; central nervous system neuron development [GO:0021954]; exploration behavior [GO:0035640]; maternal behavior [GO:0042711]; negative regulation of cell cycle [GO:0045786]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of neurogenesis [GO:0050768]; positive regulation of neuron differentiation [GO:0045666]; short-term memory [GO:0007614]; social behavior [GO:0035176]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11420708, ECO:0000269|PubMed:14712213}.
O60478	reviewed	G137B_HUMAN	Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1 protein)	GPR137B TM7SF1	Homo sapiens (Human)	399	FUNCTION: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939). {ECO:0000269|PubMed:31036939}.; FUNCTION: Acts also as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity). {ECO:0000250|UniProtKB:Q8BNQ3}.		autophagy [GO:0006914]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of protein localization to lysosome [GO:0150032]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506]; regulation of GTPase activity [GO:0043087]; regulation of macrophage activation [GO:0043030]	lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]		lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; autophagy [GO:0006914]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of protein localization to lysosome [GO:0150032]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506]; regulation of GTPase activity [GO:0043087]; regulation of macrophage activation [GO:0043030]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:22729905, ECO:0000269|PubMed:31036939}; Multi-pass membrane protein {ECO:0000269|PubMed:22729905}. Note=Colocalized with MTOR in lysosome after amino acid stimulation. {ECO:0000269|PubMed:31036939}.
O60479	reviewed	DLX3_HUMAN	Homeobox protein DLX-3	DLX3	Homo sapiens (Human)	287	FUNCTION: Transcriptional activator (By similarity). Activates transcription of GNRHR, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q64205}.		blood vessel development [GO:0001568]; BMP signaling pathway [GO:0030509]; epithelial cell differentiation [GO:0030855]; gene expression [GO:0010467]; hair cell differentiation [GO:0035315]; hair follicle cell proliferation [GO:0071335]; hair follicle morphogenesis [GO:0031069]; odontoblast differentiation [GO:0071895]; odontogenesis of dentin-containing tooth [GO:0042475]; placenta development [GO:0001890]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; blood vessel development [GO:0001568]; BMP signaling pathway [GO:0030509]; epithelial cell differentiation [GO:0030855]; gene expression [GO:0010467]; hair cell differentiation [GO:0035315]; hair follicle cell proliferation [GO:0071335]; hair follicle morphogenesis [GO:0031069]; odontoblast differentiation [GO:0071895]; odontogenesis of dentin-containing tooth [GO:0042475]; placenta development [GO:0001890]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. Cytoplasm {ECO:0000250|UniProtKB:Q64205}.
O60481	reviewed	ZIC3_HUMAN	Zinc finger protein ZIC 3 (Zinc finger protein 203) (Zinc finger protein of the cerebellum 3)	ZIC3 ZNF203	Homo sapiens (Human)	467	FUNCTION: Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:17764085}.		atrial cardiac muscle tissue development [GO:0003228]; axial mesoderm development [GO:0048318]; central nervous system development [GO:0007417]; central nervous system segmentation [GO:0035283]; cranial skeletal system development [GO:1904888]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of left/right asymmetry in nervous system [GO:0035545]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; embryonic pattern specification [GO:0009880]; face development [GO:0060324]; germ-line stem cell population maintenance [GO:0030718]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; left/right axis specification [GO:0070986]; limb morphogenesis [GO:0035108]; lung development [GO:0030324]; mRNA transcription by RNA polymerase II [GO:0042789]; neural plate development [GO:0001840]; neuron differentiation [GO:0030182]; olfactory bulb development [GO:0021772]; outer ear morphogenesis [GO:0042473]; paraxial mesoderm development [GO:0048339]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; stem cell differentiation [GO:0048863]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator activity [GO:0003713]; atrial cardiac muscle tissue development [GO:0003228]; axial mesoderm development [GO:0048318]; central nervous system development [GO:0007417]; central nervous system segmentation [GO:0035283]; cranial skeletal system development [GO:1904888]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of left/right asymmetry in nervous system [GO:0035545]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; embryonic pattern specification [GO:0009880]; face development [GO:0060324]; germ-line stem cell population maintenance [GO:0030718]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; left/right axis specification [GO:0070986]; limb morphogenesis [GO:0035108]; lung development [GO:0030324]; mRNA transcription by RNA polymerase II [GO:0042789]; neural plate development [GO:0001840]; neuron differentiation [GO:0030182]; olfactory bulb development [GO:0021772]; outer ear morphogenesis [GO:0042473]; paraxial mesoderm development [GO:0048339]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6. {ECO:0000250}.
O60486	reviewed	PLXC1_HUMAN	Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232)	PLXNC1 VESPR	Homo sapiens (Human)	1568	FUNCTION: Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:20727575}.		cell adhesion [GO:0007155]; negative regulation of cell adhesion [GO:0007162]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of synapse pruning [GO:1905806]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; membrane [GO:0016020]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	semaphorin receptor activity [GO:0017154]; signaling receptor binding [GO:0005102]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; membrane [GO:0016020]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]; semaphorin receptor activity [GO:0017154]; signaling receptor binding [GO:0005102]; cell adhesion [GO:0007155]; negative regulation of cell adhesion [GO:0007162]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of synapse pruning [GO:1905806]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O60487	reviewed	MPZL2_HUMAN	Myelin protein zero-like protein 2 (Epithelial V-like antigen 1)	MPZL2 EVA EVA1 UNQ606/PRO1192	Homo sapiens (Human)	215	FUNCTION: Mediates homophilic cell-cell adhesion.		anatomical structure morphogenesis [GO:0009653]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]		cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; anatomical structure morphogenesis [GO:0009653]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O60488	reviewed	ACSL4_HUMAN	Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4)	ACSL4 ACS4 FACL4 LACS4	Homo sapiens (Human)	711	FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590). {ECO:0000250|UniProtKB:O35547, ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}.		embryonic process involved in female pregnancy [GO:0060136]; fatty acid metabolic process [GO:0006631]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; negative regulation of prostaglandin secretion [GO:0032307]; neuron differentiation [GO:0030182]; positive regulation of cell growth [GO:0030307]; positive regulation of insulin secretion [GO:0032024]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]	arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; palmitoyl-CoA ligase activity [GO:0090433]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]; arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; palmitoyl-CoA ligase activity [GO:0090433]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; embryonic process involved in female pregnancy [GO:0060136]; fatty acid metabolic process [GO:0006631]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; negative regulation of prostaglandin secretion [GO:0032307]; neuron differentiation [GO:0030182]; positive regulation of cell growth [GO:0030307]; positive regulation of insulin secretion [GO:0032024]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24269233}; Single-pass type III membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:24269233}.
O60493	reviewed	SNX3_HUMAN	Sorting nexin-3 (Protein SDP3)	SNX3	Homo sapiens (Human)	162	FUNCTION: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282, PubMed:30213940). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551). {ECO:0000250|UniProtKB:O70492, ECO:0000269|PubMed:11433298, ECO:0000269|PubMed:18767904, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:23237080, ECO:0000269|PubMed:24344282, ECO:0000305|PubMed:21725319}.		endocytic recycling [GO:0032456]; intralumenal vesicle formation [GO:0070676]; late endosome to Golgi transport [GO:0034499]; membrane invagination [GO:0010324]; negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein transport [GO:0051224]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of neuron projection development [GO:0010976]; protein to membrane docking [GO:0022615]; protein transport [GO:0015031]; regulation of Wnt signaling pathway [GO:0030111]; response to bacterium [GO:0009617]	clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; retromer complex [GO:0030904]	phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protein phosphatase binding [GO:0019903]; retromer complex binding [GO:1905394]	clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; retromer complex [GO:0030904]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protein phosphatase binding [GO:0019903]; retromer complex binding [GO:1905394]; endocytic recycling [GO:0032456]; intralumenal vesicle formation [GO:0070676]; late endosome to Golgi transport [GO:0034499]; membrane invagination [GO:0010324]; negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein transport [GO:0051224]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of neuron projection development [GO:0010976]; protein to membrane docking [GO:0022615]; protein transport [GO:0015031]; regulation of Wnt signaling pathway [GO:0030111]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:11433298, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:30213940}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:23237080}. Note=Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer-decorated non-branched endosomal tubule structures (PubMed:21725319) Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (PubMed:23237080). In the case of Salmonella enterica infection localizes to Salmonella-containing vacuoles (SCVs) from which SNX3-containing tubules form 30-60 min after infection (PubMed:20482551). {ECO:0000269|PubMed:20482551, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:23237080}.
O60494	reviewed	CUBN_HUMAN	Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor)	CUBN IFCR	Homo sapiens (Human)	3623	FUNCTION: Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PubMed:9572993, PubMed:10371504, PubMed:11717447, PubMed:11606717, PubMed:14576052). Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex (PubMed:9572993, PubMed:14576052). Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium (PubMed:9572993). Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. {ECO:0000269|PubMed:10371504, ECO:0000269|PubMed:11606717, ECO:0000269|PubMed:11717447, ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:9572993}.		cholesterol metabolic process [GO:0008203]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; establishment of localization in cell [GO:0051649]; lipoprotein transport [GO:0042953]; receptor-mediated endocytosis [GO:0006898]; response to bacterium [GO:0009617]; tissue homeostasis [GO:0001894]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extrinsic component of external side of plasma membrane [GO:0031232]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; cobalamin binding [GO:0031419]; protein homodimerization activity [GO:0042803]; signaling receptor activity [GO:0038023]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extrinsic component of external side of plasma membrane [GO:0031232]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; cobalamin binding [GO:0031419]; protein homodimerization activity [GO:0042803]; signaling receptor activity [GO:0038023]; cholesterol metabolic process [GO:0008203]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; establishment of localization in cell [GO:0051649]; lipoprotein transport [GO:0042953]; receptor-mediated endocytosis [GO:0006898]; response to bacterium [GO:0009617]; tissue homeostasis [GO:0001894]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9JLB4}; Peripheral membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:29402915, ECO:0000269|PubMed:30523278}; Peripheral membrane protein {ECO:0000305, ECO:0000305|PubMed:30523278}. Membrane, coated pit {ECO:0000269|PubMed:14576052}. Endosome {ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:29402915}. Lysosome membrane {ECO:0000250|UniProtKB:O70244}; Peripheral membrane protein {ECO:0000305}. Note=Lacks a transmembrane domain and depends on interaction with AMN for location at the plasma membrane (PubMed:29402915, PubMed:30523278). Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells (By similarity). {ECO:0000250|UniProtKB:O70244, ECO:0000269|PubMed:29402915, ECO:0000269|PubMed:30523278}.
O60496	reviewed	DOK2_HUMAN	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))	DOK2	Homo sapiens (Human)	412	FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}.		cell surface receptor signaling pathway [GO:0007166]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	
O60499	reviewed	STX10_HUMAN	Syntaxin-10 (Syn10)	STX10 SYN10	Homo sapiens (Human)	249	FUNCTION: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}.		Golgi vesicle transport [GO:0048193]; intracellular protein transport [GO:0006886]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; Golgi vesicle transport [GO:0048193]; intracellular protein transport [GO:0006886]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
O60500	reviewed	NPHN_HUMAN	Nephrin (Renal glomerulus-specific cell adhesion receptor)	NPHS1 NPHN	Homo sapiens (Human)	1241	FUNCTION: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity). {ECO:0000250|UniProtKB:Q9QZS7, ECO:0000250|UniProtKB:Q9R044}.		cell-cell adhesion [GO:0098609]; glomerular basement membrane development [GO:0032836]; JNK cascade [GO:0007254]; myoblast fusion [GO:0007520]; podocyte development [GO:0072015]; positive regulation of actin filament polymerization [GO:0030838]; protein localization to synapse [GO:0035418]; skeletal muscle tissue development [GO:0007519]; slit diaphragm assembly [GO:0036060]	cell projection [GO:0042995]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057]	cell adhesion molecule binding [GO:0050839]; myosin binding [GO:0017022]	cell projection [GO:0042995]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057]; cell adhesion molecule binding [GO:0050839]; myosin binding [GO:0017022]; cell-cell adhesion [GO:0098609]; glomerular basement membrane development [GO:0032836]; JNK cascade [GO:0007254]; myoblast fusion [GO:0007520]; podocyte development [GO:0072015]; positive regulation of actin filament polymerization [GO:0030838]; protein localization to synapse [GO:0035418]; skeletal muscle tissue development [GO:0007519]; slit diaphragm assembly [GO:0036060]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane. {ECO:0000269|PubMed:10393930, ECO:0000269|PubMed:10550324}.
O60502	reviewed	OGA_HUMAN	Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT)	OGA HEXC KIAA0679 MEA5 MGEA5	Homo sapiens (Human)	916	FUNCTION: [Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11788610, ECO:0000269|PubMed:20673219, ECO:0000269|PubMed:22365600, ECO:0000269|PubMed:24088714}.; FUNCTION: [Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. {ECO:0000269|PubMed:20673219}.		glycoprotein catabolic process [GO:0006516]; glycoprotein metabolic process [GO:0009100]; N-acetylglucosamine metabolic process [GO:0006044]; protein deglycosylation [GO:0006517]; protein O-linked glycosylation [GO:0006493]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102167]; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102571]; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102166]; beta-N-acetylglucosaminidase activity [GO:0016231]; hyalurononglucosaminidase activity [GO:0004415]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102167]; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102571]; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102166]; beta-N-acetylglucosaminidase activity [GO:0016231]; hyalurononglucosaminidase activity [GO:0004415]; identical protein binding [GO:0042802]; glycoprotein catabolic process [GO:0006516]; glycoprotein metabolic process [GO:0009100]; N-acetylglucosamine metabolic process [GO:0006044]; protein deglycosylation [GO:0006517]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:11341771}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11341771, ECO:0000269|PubMed:11788610}.
O60503	reviewed	ADCY9_HUMAN	Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9)	ADCY9 KIAA0520	Homo sapiens (Human)	1353	FUNCTION: Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}.		adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; in utero embryonic development [GO:0001701]; intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; in utero embryonic development [GO:0001701]; intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:9628827}; Multi-pass membrane protein {ECO:0000305}.
O60504	reviewed	VINEX_HUMAN	Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)	SORBS3 SCAM1	Homo sapiens (Human)	671	FUNCTION: Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.		cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; MAPK cascade [GO:0000165]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of stress fiber assembly [GO:0051496]	cell-substrate junction [GO:0030055]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]	structural constituent of cytoskeleton [GO:0005200]; vinculin binding [GO:0017166]	cell-substrate junction [GO:0030055]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; structural constituent of cytoskeleton [GO:0005200]; vinculin binding [GO:0017166]; cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; MAPK cascade [GO:0000165]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of stress fiber assembly [GO:0051496]	SUBCELLULAR LOCATION: [Isoform Alpha]: Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform Beta]: Cell junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus. {ECO:0000250}.
O60506	reviewed	HNRPQ_HUMAN	Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)	SYNCRIP HNRPQ NSAP1	Homo sapiens (Human)	623	FUNCTION: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:11134005, ECO:0000269|PubMed:11352648, ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23071094}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to a competing donor splice site and to an exon inclusion. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be due to a competing donor splice site and to an exon inclusion. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be due to a competing donor splice site and to an exon inclusion. {ECO:0000305}.	cellular response to type II interferon [GO:0071346]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA modification [GO:0016556]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; negative regulation of translation [GO:0017148]; osteoblast differentiation [GO:0001649]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA demethylation [GO:1901537]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	catalytic step 2 spliceosome [GO:0071013]; CRD-mediated mRNA stability complex [GO:0070937]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; GAIT complex [GO:0097452]; histone pre-mRNA 3'end processing complex [GO:0071204]; mCRD-mediated mRNA stability complex [GO:0106002]; membrane [GO:0016020]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; CRD-mediated mRNA stability complex [GO:0070937]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; GAIT complex [GO:0097452]; histone pre-mRNA 3'end processing complex [GO:0071204]; mCRD-mediated mRNA stability complex [GO:0106002]; membrane [GO:0016020]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; cellular response to type II interferon [GO:0071346]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA modification [GO:0016556]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; negative regulation of translation [GO:0017148]; osteoblast differentiation [GO:0001649]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA demethylation [GO:1901537]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:35538151}. Microsome {ECO:0000250|UniProtKB:Q7TMK9}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250|UniProtKB:Q7TMK9}. Note=The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). {ECO:0000250|UniProtKB:O43390, ECO:0000250|UniProtKB:Q7TMK9}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TMK9}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250|UniProtKB:Q7TMK9}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TMK9}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250|UniProtKB:Q7TMK9}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TMK9}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250|UniProtKB:Q7TMK9}.
O60507	reviewed	TPST1_HUMAN	Protein-tyrosine sulfotransferase 1 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 1) (TPST-1)	TPST1	Homo sapiens (Human)	370	FUNCTION: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. {ECO:0000269|PubMed:28821720, ECO:0000269|PubMed:9501187, ECO:0000269|PubMed:9733778}.		3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; inflammatory response [GO:0006954]; peptidyl-tyrosine sulfation [GO:0006478]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	protein homodimerization activity [GO:0042803]; protein-tyrosine sulfotransferase activity [GO:0008476]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; protein homodimerization activity [GO:0042803]; protein-tyrosine sulfotransferase activity [GO:0008476]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; inflammatory response [GO:0006954]; peptidyl-tyrosine sulfation [GO:0006478]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16859706, ECO:0000269|PubMed:25660941}; Single-pass type II membrane protein {ECO:0000269|PubMed:25660941, ECO:0000305|PubMed:16859706}.
O60508	reviewed	PRP17_HUMAN	Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17)	CDC40 EHB3 PRP17 PRPF17	Homo sapiens (Human)	579	FUNCTION: Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:33220177, ECO:0000269|PubMed:9830021}.		embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; U2-type catalytic step 2 spliceosome [GO:0071007]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; U2-type catalytic step 2 spliceosome [GO:0071007]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154}. Nucleus speckle {ECO:0000269|PubMed:9830021}.
O60512	reviewed	B4GT3_HUMAN	Beta-1,4-galactosyltransferase 3 (Beta-1,4-GalTase 3) (Beta4Gal-T3) (b4Gal-T3) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3)	B4GALT3	Homo sapiens (Human)	393	FUNCTION: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. {ECO:0000269|PubMed:11588157, ECO:0000269|PubMed:9405390}.		carbohydrate metabolic process [GO:0005975]; galactosylceramide biosynthetic process [GO:0006682]; glycosylation [GO:0070085]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]; carbohydrate metabolic process [GO:0005975]; galactosylceramide biosynthetic process [GO:0006682]; glycosylation [GO:0070085]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.
O60513	reviewed	B4GT4_HUMAN	Beta-1,4-galactosyltransferase 4 (Beta-1,4-GalTase 4) (Beta4Gal-T4) (b4Gal-T4) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Lactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4)	B4GALT4 UNQ552/PRO1109	Homo sapiens (Human)	344	FUNCTION: Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids (PubMed:9792633, PubMed:17690104, PubMed:12511560, PubMed:32827291). Catalyzes the transfer of Gal residue via a beta1->4 linkage from UDP-Gal to the non-reducing terminal N-acetyl glucosamine 6-O-sulfate (6-O-sulfoGlcNAc) in the linearly growing chain of both N- and O-linked keratan sulfate proteoglycans. Cooperates with B3GNT7 N-acetyl glucosamine transferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (PubMed:17690104). Transfers Gal residue via a beta1->4 linkage to terminal 6-O-sulfoGlcNAc within the LacNac unit of core 2 O-glycans forming 6-sulfo-sialyl-Lewis X (sLex). May contribute to the generation of sLex epitope on mucin-type glycoproteins that serve as ligands for SELL/L-selectin, a major regulator of leukocyte migration (PubMed:12511560). In the biosynthesis pathway of neolacto-series glycosphingolipids, transfers Gal residue via a beta1->4 linkage to terminal GlcNAc of a lactotriaosylceramide (Lc3Cer) acceptor to form a neolactotetraosylceramide (PubMed:9792633). {ECO:0000269|PubMed:12511560, ECO:0000269|PubMed:17690104, ECO:0000269|PubMed:9792633}.		carbohydrate metabolic process [GO:0005975]; glycosylation [GO:0070085]; keratan sulfate biosynthetic process [GO:0018146]; lactosylceramide biosynthetic process [GO:0001572]; membrane lipid metabolic process [GO:0006643]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]; UDP-galactosyltransferase activity [GO:0035250]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]; UDP-galactosyltransferase activity [GO:0035250]; carbohydrate metabolic process [GO:0005975]; glycosylation [GO:0070085]; keratan sulfate biosynthetic process [GO:0018146]; lactosylceramide biosynthetic process [GO:0001572]; membrane lipid metabolic process [GO:0006643]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:32827291}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:32827291}.
O60516	reviewed	4EBP3_HUMAN	Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3)	EIF4EBP3	Homo sapiens (Human)	100	FUNCTION: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:22684010). {ECO:0000250|UniProtKB:Q13541, ECO:0000269|PubMed:22684010}.		negative regulation of translational initiation [GO:0045947]	cytoplasm [GO:0005737]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]	eukaryotic initiation factor 4E binding [GO:0008190]; translation repressor activity [GO:0030371]	cytoplasm [GO:0005737]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; eukaryotic initiation factor 4E binding [GO:0008190]; translation repressor activity [GO:0030371]; negative regulation of translational initiation [GO:0045947]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22684010}. Nucleus {ECO:0000269|PubMed:22684010}.
O60519	reviewed	CRBL2_HUMAN	cAMP-responsive element-binding protein-like 2	CREBL2	Homo sapiens (Human)	120	FUNCTION: Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor. {ECO:0000269|PubMed:9693048}.		cell cycle [GO:0007049]; cell differentiation [GO:0030154]; DNA-templated transcription [GO:0006351]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucose import [GO:0046326]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; DNA-templated transcription [GO:0006351]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucose import [GO:0046326]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
O60524	reviewed	NEMF_HUMAN	Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1)	NEMF SDCCAG1	Homo sapiens (Human)	1076	FUNCTION: Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:25578875, PubMed:32726578, PubMed:33406423, PubMed:33909987). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:25578875, PubMed:33406423, PubMed:33909987). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (PubMed:25578875). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423, PubMed:33909987). Mainly recruits alanine-charged tRNAs, but can also other amino acid-charged tRNAs (PubMed:33406423, PubMed:33909987). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (PubMed:33909987). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (PubMed:33909987). NEMF may also indirectly play a role in nuclear export (PubMed:16103875). {ECO:0000250|UniProtKB:Q12532, ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:25578875, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33406423, ECO:0000269|PubMed:33909987}.		CAT tailing [GO:0140708]; nuclear export [GO:0051168]; protein-containing complex assembly [GO:0065003]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]; RQC complex [GO:1990112]	alpha-aminoacyl-tRNA binding [GO:1904678]; ribosomal large subunit binding [GO:0043023]; tRNA binding [GO:0000049]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]; RQC complex [GO:1990112]; alpha-aminoacyl-tRNA binding [GO:1904678]; ribosomal large subunit binding [GO:0043023]; tRNA binding [GO:0000049]; CAT tailing [GO:0140708]; nuclear export [GO:0051168]; protein-containing complex assembly [GO:0065003]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25578875}. Nucleus {ECO:0000305|PubMed:16103875}.
O60543	reviewed	CIDEA_HUMAN	Lipid transferase CIDEA (Cell death activator CIDE-A) (Cell death-inducing DFFA-like effector A)	CIDEA	Homo sapiens (Human)	219	FUNCTION: Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:19843876, PubMed:26118629). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:19843876). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC (By similarity). May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein (By similarity). By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). When overexpressed, induces apoptosis; the physiological significance of its role in apoptosis is unclear (By similarity). {ECO:0000250|UniProtKB:O70302, ECO:0000269|PubMed:19843876, ECO:0000269|PubMed:26118629}.		apoptotic process [GO:0006915]; cellular response to cold [GO:0070417]; lipid droplet fusion [GO:0160077]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of cytokine production [GO:0001818]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of sequestering of triglyceride [GO:0010890]; regulation of apoptotic DNA fragmentation [GO:1902510]; regulation of apoptotic process [GO:0042981]; response to stilbenoid [GO:0035634]; temperature homeostasis [GO:0001659]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; mitochondrial envelope [GO:0005740]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	lipid transfer activity [GO:0120013]; phosphatidic acid binding [GO:0070300]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; mitochondrial envelope [GO:0005740]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; lipid transfer activity [GO:0120013]; phosphatidic acid binding [GO:0070300]; protein homodimerization activity [GO:0042803]; apoptotic process [GO:0006915]; cellular response to cold [GO:0070417]; lipid droplet fusion [GO:0160077]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of cytokine production [GO:0001818]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of sequestering of triglyceride [GO:0010890]; regulation of apoptotic DNA fragmentation [GO:1902510]; regulation of apoptotic process [GO:0042981]; response to stilbenoid [GO:0035634]; temperature homeostasis [GO:0001659]	SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:18509062}. Nucleus {ECO:0000250|UniProtKB:O70302}. Note=Enriched at lipid droplet contact sites. {ECO:0000269|PubMed:18509062}.
O60547	reviewed	GMDS_HUMAN	GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)	GMDS	Homo sapiens (Human)	372	FUNCTION: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. {ECO:0000269|PubMed:9525924, ECO:0000269|PubMed:9603974}.		'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; GDP-mannose metabolic process [GO:0019673]; Notch signaling pathway [GO:0007219]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GDP-mannose 4,6-dehydratase activity [GO:0008446]; identical protein binding [GO:0042802]; NADP+ binding [GO:0070401]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GDP-mannose 4,6-dehydratase activity [GO:0008446]; identical protein binding [GO:0042802]; NADP+ binding [GO:0070401]; 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; GDP-mannose metabolic process [GO:0019673]; Notch signaling pathway [GO:0007219]	
O60548	reviewed	FOXD2_HUMAN	Forkhead box protein D2 (Forkhead-related protein FKHL17) (Forkhead-related transcription factor 9) (FREAC-9)	FOXD2 FKHL17 FREAC9	Homo sapiens (Human)	495	FUNCTION: Probable transcription factor involved in embryogenesis and somatogenesis. {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
O60551	reviewed	NMT2_HUMAN	Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Peptide N-myristoyltransferase 2) (Protein-lysine myristoyltransferase NMT2) (EC 2.3.1.-) (Type II N-myristoyltransferase)	NMT2	Homo sapiens (Human)	498	FUNCTION: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:25255805, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017). {ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:9506952}.		intracellular transport of virus [GO:0075733]; N-terminal peptidyl-glycine N-myristoylation [GO:0018008]; regulation of rhodopsin mediated signaling pathway [GO:0022400]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; host cell [GO:0043657]; plasma membrane [GO:0005886]	glycylpeptide N-tetradecanoyltransferase activity [GO:0004379]; peptidyl-lysine N6-myristoyltransferase activity [GO:0018030]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; host cell [GO:0043657]; plasma membrane [GO:0005886]; glycylpeptide N-tetradecanoyltransferase activity [GO:0004379]; peptidyl-lysine N6-myristoyltransferase activity [GO:0018030]; intracellular transport of virus [GO:0075733]; N-terminal peptidyl-glycine N-myristoylation [GO:0018008]; regulation of rhodopsin mediated signaling pathway [GO:0022400]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9506952}. Membrane {ECO:0000269|PubMed:9506952}; Peripheral membrane protein {ECO:0000269|PubMed:9506952}.
O60563	reviewed	CCNT1_HUMAN	Cyclin-T1 (CycT1) (Cyclin-T)	CCNT1	Homo sapiens (Human)	726	FUNCTION: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:35393539, PubMed:30134174). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}.		cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366]	cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-TEFb complex [GO:0070691]	7SK snRNA binding [GO:0097322]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; molecular condensate scaffold activity [GO:0140693]; protein kinase binding [GO:0019901]; RNA polymerase binding [GO:0070063]; transcription cis-regulatory region binding [GO:0000976]	cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-TEFb complex [GO:0070691]; 7SK snRNA binding [GO:0097322]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; molecular condensate scaffold activity [GO:0140693]; protein kinase binding [GO:0019901]; RNA polymerase binding [GO:0070063]; transcription cis-regulatory region binding [GO:0000976]; cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:29849146}.
O60565	reviewed	GREM1_HUMAN	Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2)	GREM1 CKTSF1B1 DAND2 DRM PIG2	Homo sapiens (Human)	184	FUNCTION: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). {ECO:0000250|UniProtKB:O35793, ECO:0000250|UniProtKB:O70326, ECO:0000269|PubMed:27036124}.		animal organ morphogenesis [GO:0009887]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell morphogenesis [GO:0000902]; cell-cell signaling [GO:0007267]; collagen fibril organization [GO:0030199]; determination of dorsal identity [GO:0048263]; embryonic limb morphogenesis [GO:0030326]; limb development [GO:0060173]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of bone mineralization [GO:0030502]; negative regulation of bone mineralization involved in bone maturation [GO:1900158]; negative regulation of bone remodeling [GO:0046851]; negative regulation of bone trabecula formation [GO:1900155]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of osteoclast proliferation [GO:0090291]; positive regulation of angiogenesis [GO:0045766]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of receptor internalization [GO:0002092]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; sequestering of BMP from receptor via BMP binding [GO:0038098]; signal transduction [GO:0007165]; ureteric bud formation [GO:0060676]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]	BMP binding [GO:0036122]; cytokine activity [GO:0005125]; morphogen activity [GO:0016015]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; vascular endothelial growth factor receptor 2 binding [GO:0043184]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; BMP binding [GO:0036122]; cytokine activity [GO:0005125]; morphogen activity [GO:0016015]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; animal organ morphogenesis [GO:0009887]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell morphogenesis [GO:0000902]; cell-cell signaling [GO:0007267]; collagen fibril organization [GO:0030199]; determination of dorsal identity [GO:0048263]; embryonic limb morphogenesis [GO:0030326]; limb development [GO:0060173]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of bone mineralization [GO:0030502]; negative regulation of bone mineralization involved in bone maturation [GO:1900158]; negative regulation of bone remodeling [GO:0046851]; negative regulation of bone trabecula formation [GO:1900155]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of osteoclast proliferation [GO:0090291]; positive regulation of angiogenesis [GO:0045766]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of receptor internalization [GO:0002092]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; sequestering of BMP from receptor via BMP binding [GO:0038098]; signal transduction [GO:0007165]; ureteric bud formation [GO:0060676]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O60566	reviewed	BUB1B_HUMAN	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)	BUB1B BUBR1 MAD3L SSK1	Homo sapiens (Human)	1050	FUNCTION: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}.		apoptotic process [GO:0006915]; cell division [GO:0051301]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic spindle assembly checkpoint signaling [GO:0007094]; phosphorylation [GO:0016310]; protein localization to chromosome, centromeric region [GO:0071459]	anaphase-promoting complex [GO:0005680]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule organizing center [GO:0005815]; mitotic checkpoint complex [GO:0033597]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	anaphase-promoting complex [GO:0005680]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule organizing center [GO:0005815]; mitotic checkpoint complex [GO:0033597]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cell division [GO:0051301]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic spindle assembly checkpoint signaling [GO:0007094]; phosphorylation [GO:0016310]; protein localization to chromosome, centromeric region [GO:0071459]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and KNL1.
O60568	reviewed	PLOD3_HUMAN	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]	PLOD3	Homo sapiens (Human)	738	FUNCTION: Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968). Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:9582318, PubMed:9724729, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:10934207, PubMed:11896059, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968). Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660). Essential for normal biosynthesis and secretion of type IV collagens (PubMed:18834968) (Probable). Essential for normal formation of basement membranes (By similarity). {ECO:0000250|UniProtKB:Q9R0E1, ECO:0000269|PubMed:10934207, ECO:0000269|PubMed:11896059, ECO:0000269|PubMed:11956192, ECO:0000269|PubMed:12475640, ECO:0000269|PubMed:18298658, ECO:0000269|PubMed:18834968, ECO:0000269|PubMed:25419660, ECO:0000269|PubMed:30089812, ECO:0000269|PubMed:9582318, ECO:0000269|PubMed:9724729, ECO:0000305}.		basement membrane assembly [GO:0070831]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endothelial cell morphogenesis [GO:0001886]; epidermis morphogenesis [GO:0048730]; hydroxylysine biosynthetic process [GO:0046947]; in utero embryonic development [GO:0001701]; lung morphogenesis [GO:0060425]; neural tube development [GO:0021915]; peptidyl-lysine hydroxylation [GO:0017185]; protein localization [GO:0008104]; protein O-linked glycosylation [GO:0006493]; vasodilation [GO:0042311]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; rough endoplasmic reticulum [GO:0005791]; trans-Golgi network [GO:0005802]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; metal ion binding [GO:0046872]; procollagen galactosyltransferase activity [GO:0050211]; procollagen glucosyltransferase activity [GO:0033823]; procollagen-lysine 5-dioxygenase activity [GO:0008475]; small molecule binding [GO:0036094]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; rough endoplasmic reticulum [GO:0005791]; trans-Golgi network [GO:0005802]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; metal ion binding [GO:0046872]; procollagen galactosyltransferase activity [GO:0050211]; procollagen glucosyltransferase activity [GO:0033823]; procollagen-lysine 5-dioxygenase activity [GO:0008475]; small molecule binding [GO:0036094]; basement membrane assembly [GO:0070831]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endothelial cell morphogenesis [GO:0001886]; epidermis morphogenesis [GO:0048730]; hydroxylysine biosynthetic process [GO:0046947]; in utero embryonic development [GO:0001701]; lung morphogenesis [GO:0060425]; neural tube development [GO:0021915]; peptidyl-lysine hydroxylation [GO:0017185]; protein localization [GO:0008104]; protein O-linked glycosylation [GO:0006493]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Rough endoplasmic reticulum {ECO:0000269|PubMed:10934207}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:20470363}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9R0E1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9R0E1}; Lumenal side {ECO:0000250|UniProtKB:Q9R0E1}. Secreted {ECO:0000269|PubMed:21465473}. Secreted, extracellular space {ECO:0000250|UniProtKB:Q9R0E1}. Note=The majority of the secreted protein is associated with the extracellular matrix. {ECO:0000250|UniProtKB:Q9R0E1}.
O60573	reviewed	IF4E2_HUMAN	Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3)	EIF4E2 EIF4EL3	Homo sapiens (Human)	245	FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation (PubMed:17368478, PubMed:22751931, PubMed:25624349, PubMed:33581076, PubMed:9582349). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). In P-bodies, component of a complex that promotes miRNA-mediated translational repression (PubMed:28487484). Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism (PubMed:28487484, PubMed:33581076). {ECO:0000250|UniProtKB:Q8BMB3, ECO:0000269|PubMed:17368478, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:33581076, ECO:0000269|PubMed:9582349}.; FUNCTION: Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:35878012). In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) with GIGYF2 enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}.		miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; rescue of stalled ribosome [GO:0072344]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; mRNA cap binding complex [GO:0005845]; P-body [GO:0000932]	RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; mRNA cap binding complex [GO:0005845]; P-body [GO:0000932]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; ubiquitin protein ligase binding [GO:0031625]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; rescue of stalled ribosome [GO:0072344]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23991149}. Cytoplasm, P-body {ECO:0000269|PubMed:23991149}.
O60583	reviewed	CCNT2_HUMAN	Cyclin-T2 (CycT2)	CCNT2	Homo sapiens (Human)	730	FUNCTION: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). {ECO:0000250|UniProtKB:Q7TQK0, ECO:0000269|PubMed:11713533, ECO:0000269|PubMed:15563843, ECO:0000269|PubMed:16331689, ECO:0000269|PubMed:9499409}.; FUNCTION: (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. {ECO:0000269|PubMed:21509660}.		cell cycle [GO:0007049]; cell division [GO:0051301]; early viral transcription [GO:0019085]; late viral transcription [GO:0019086]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of muscle cell differentiation [GO:0051147]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue development [GO:0007519]; transcription by RNA polymerase II [GO:0006366]	cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	7SK snRNA binding [GO:0097322]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; protein kinase binding [GO:0019901]; RNA polymerase binding [GO:0070063]; transcription coactivator binding [GO:0001223]	cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; 7SK snRNA binding [GO:0097322]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; protein kinase binding [GO:0019901]; RNA polymerase binding [GO:0070063]; transcription coactivator binding [GO:0001223]; cell cycle [GO:0007049]; cell division [GO:0051301]; early viral transcription [GO:0019085]; late viral transcription [GO:0019086]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of muscle cell differentiation [GO:0051147]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue development [GO:0007519]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TQK0}. Nucleus {ECO:0000250|UniProtKB:Q7TQK0}. Note=Nucleus in differentiating cells. {ECO:0000250|UniProtKB:Q7TQK0}.
O60602	reviewed	TLR5_HUMAN	Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)	TLR5 TIL3	Homo sapiens (Human)	858	FUNCTION: Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity). {ECO:0000250|UniProtKB:Q9JLF7, ECO:0000269|PubMed:11323673, ECO:0000269|PubMed:11489966, ECO:0000269|PubMed:18490781, ECO:0000269|PubMed:20855887, ECO:0000269|PubMed:29934223}.		cellular response to mechanical stimulus [GO:0071260]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of interleukin-8 production [GO:0032757]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor signaling pathway [GO:0002224]	plasma membrane [GO:0005886]	interleukin-1 receptor binding [GO:0005149]; pattern recognition receptor activity [GO:0038187]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; interleukin-1 receptor binding [GO:0005149]; pattern recognition receptor activity [GO:0038187]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; cellular response to mechanical stimulus [GO:0071260]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of interleukin-8 production [GO:0032757]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor signaling pathway [GO:0002224]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24778236}; Single-pass type I membrane protein {ECO:0000255}.
O60603	reviewed	TLR2_HUMAN	Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)	TLR2 TIL4	Homo sapiens (Human)	784	FUNCTION: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity). {ECO:0000250|UniProtKB:Q9QUN7, ECO:0000269|PubMed:10426995, ECO:0000269|PubMed:10426996, ECO:0000269|PubMed:11441107, ECO:0000269|PubMed:15809303, ECO:0000269|PubMed:16622205, ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:17889651, ECO:0000269|PubMed:19362712, ECO:0000269|PubMed:21078852}.		apoptotic process [GO:0006915]; cellular response to bacterial lipopeptide [GO:0071221]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; cellular response to type II interferon [GO:0071346]; central nervous system myelin formation [GO:0032289]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; detection of diacyl bacterial lipopeptide [GO:0042496]; detection of triacyl bacterial lipopeptide [GO:0042495]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; learning [GO:0007612]; leukotriene metabolic process [GO:0006691]; microglia development [GO:0014005]; microglial cell activation [GO:0001774]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phagocytosis [GO:0050765]; negative regulation of synapse assembly [GO:0051964]; nitric oxide metabolic process [GO:0046209]; positive regulation of cellular response to macrophage colony-stimulating factor stimulus [GO:1903974]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of Wnt signaling pathway [GO:0030177]; response to fatty acid [GO:0070542]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; signal transduction [GO:0007165]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]	cell body [GO:0044297]; cell projection [GO:0042995]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; secretory granule membrane [GO:0030667]; Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; pattern recognition receptor activity [GO:0038187]; peptidoglycan binding [GO:0042834]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; Toll-like receptor binding [GO:0035325]; transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497]	cell body [GO:0044297]; cell projection [GO:0042995]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; secretory granule membrane [GO:0030667]; Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]; amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; pattern recognition receptor activity [GO:0038187]; peptidoglycan binding [GO:0042834]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; Toll-like receptor binding [GO:0035325]; transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497]; apoptotic process [GO:0006915]; cellular response to bacterial lipopeptide [GO:0071221]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; cellular response to type II interferon [GO:0071346]; central nervous system myelin formation [GO:0032289]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; detection of diacyl bacterial lipopeptide [GO:0042496]; detection of triacyl bacterial lipopeptide [GO:0042495]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; learning [GO:0007612]; leukotriene metabolic process [GO:0006691]; microglia development [GO:0014005]; microglial cell activation [GO:0001774]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phagocytosis [GO:0050765]; negative regulation of synapse assembly [GO:0051964]; nitric oxide metabolic process [GO:0046209]; positive regulation of cellular response to macrophage colony-stimulating factor stimulus [GO:1903974]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of Wnt signaling pathway [GO:0030177]; response to fatty acid [GO:0070542]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; signal transduction [GO:0007165]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:16880211}. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determines the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers. {ECO:0000269|PubMed:16880211}.
O60609	reviewed	GFRA3_HUMAN	GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3)	GFRA3 UNQ339/PRO538/PRO3664	Homo sapiens (Human)	400	FUNCTION: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. {ECO:0000269|PubMed:9883723}.		nervous system development [GO:0007399]; neuron migration [GO:0001764]; peripheral nervous system development [GO:0007422]; signal transduction [GO:0007165]; sympathetic nervous system development [GO:0048485]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	axon guidance receptor activity [GO:0008046]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; axon guidance receptor activity [GO:0008046]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; peripheral nervous system development [GO:0007422]; signal transduction [GO:0007165]; sympathetic nervous system development [GO:0048485]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
O60610	reviewed	DIAP1_HUMAN	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1)	DIAPH1 DIAP1	Homo sapiens (Human)	1272	FUNCTION: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}.		actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; cellular response to histamine [GO:0071420]; cytoskeleton organization [GO:0007010]; protein localization to microtubule [GO:0035372]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule-based process [GO:0032886]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; sensory perception of sound [GO:0007605]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ficolin-1-rich granule membrane [GO:0101003]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; secretory granule membrane [GO:0030667]	actin binding [GO:0003779]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ficolin-1-rich granule membrane [GO:0101003]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; secretory granule membrane [GO:0030667]; actin binding [GO:0003779]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]; actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; cellular response to histamine [GO:0071420]; cytoskeleton organization [GO:0007010]; protein localization to microtubule [GO:0035372]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule-based process [GO:0032886]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O08808}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O08808}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24781755}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24781755}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:24781755}. Cytoplasm {ECO:0000250|UniProtKB:O08808}. Nucleus {ECO:0000250|UniProtKB:O08808}. Note=Membrane ruffles, especially at the tip of ruffles, of motile cells. {ECO:0000250|UniProtKB:O08808}.
O60613	reviewed	SEP15_HUMAN	Selenoprotein F (15 kDa selenoprotein)	SELENOF SEP15	Homo sapiens (Human)	165	FUNCTION: May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum (PubMed:24415556). May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (PubMed:24415556). {ECO:0000250|UniProtKB:Q923V8, ECO:0000269|PubMed:24415556}.		'de novo' post-translational protein folding [GO:0051084]; sperm DNA condensation [GO:0035092]	endoplasmic reticulum lumen [GO:0005788]	oxidoreductase activity [GO:0016491]; selenium binding [GO:0008430]; thioredoxin peroxidase activity [GO:0008379]	endoplasmic reticulum lumen [GO:0005788]; oxidoreductase activity [GO:0016491]; selenium binding [GO:0008430]; thioredoxin peroxidase activity [GO:0008379]; 'de novo' post-translational protein folding [GO:0051084]; sperm DNA condensation [GO:0035092]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:11278576}. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.
O60635	reviewed	TSN1_HUMAN	Tetraspanin-1 (Tspan-1) (Tetraspan NET-1) (Tetraspanin TM4-C)	TSPAN1	Homo sapiens (Human)	241			protein stabilization [GO:0050821]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]		cell junction [GO:0030054]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:19508227}; Multi-pass membrane protein {ECO:0000269|PubMed:19508227}.
O60636	reviewed	TSN2_HUMAN	Tetraspanin-2 (Tspan-2) (Tetraspan NET-3)	TSPAN2	Homo sapiens (Human)	221	FUNCTION: May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath. {ECO:0000250}.		astrocyte development [GO:0014002]; axon development [GO:0061564]; inflammatory response [GO:0006954]; microglia development [GO:0014005]; myelination [GO:0042552]; oligodendrocyte differentiation [GO:0048709]	membrane [GO:0016020]; myelin sheath [GO:0043209]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		membrane [GO:0016020]; myelin sheath [GO:0043209]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; astrocyte development [GO:0014002]; axon development [GO:0061564]; inflammatory response [GO:0006954]; microglia development [GO:0014005]; myelination [GO:0042552]; oligodendrocyte differentiation [GO:0048709]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O60641	reviewed	AP180_HUMAN	Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20)	SNAP91 KIAA0656	Homo sapiens (Human)	907	FUNCTION: Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; protein transport [GO:0015031]; regulation of clathrin-dependent endocytosis [GO:2000369]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; synaptic vesicle [GO:0008021]	1-phosphatidylinositol binding [GO:0005545]; clathrin heavy chain binding [GO:0032050]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase binding [GO:0019901]; SNARE binding [GO:0000149]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; synaptic vesicle [GO:0008021]; 1-phosphatidylinositol binding [GO:0005545]; clathrin heavy chain binding [GO:0032050]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase binding [GO:0019901]; SNARE binding [GO:0000149]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; protein transport [GO:0015031]; regulation of clathrin-dependent endocytosis [GO:2000369]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.
O60645	reviewed	EXOC3_HUMAN	Exocyst complex component 3 (Exocyst complex component Sec6)	EXOC3 SEC6 SEC6L1	Homo sapiens (Human)	745	FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.		exocyst localization [GO:0051601]; exocytosis [GO:0006887]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	cytosol [GO:0005829]; exocyst [GO:0000145]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; presynaptic membrane [GO:0042734]; secretory granule membrane [GO:0030667]	cadherin binding [GO:0045296]; SNARE binding [GO:0000149]	cytosol [GO:0005829]; exocyst [GO:0000145]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; presynaptic membrane [GO:0042734]; secretory granule membrane [GO:0030667]; cadherin binding [GO:0045296]; SNARE binding [GO:0000149]; exocyst localization [GO:0051601]; exocytosis [GO:0006887]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54921}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54921}. Cell projection, growth cone {ECO:0000250|UniProtKB:O54921}. Midbody {ECO:0000269|PubMed:18756269}. Golgi apparatus {ECO:0000305|PubMed:18756269}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q62825}. Note=Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). During mitosis, early recruitment to the midbody requires RALA, but not RALB, and EXOC2. In late stages of cytokinesis, localization to the midbody is RALB-dependent (PubMed:18756269). {ECO:0000250|UniProtKB:O54921, ECO:0000269|PubMed:18756269}.
O60656	reviewed	UD19_HUMAN	UDP-glucuronosyltransferase 1A9 (UGT1A9) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-9) (UDPGT 1-9) (UGT1*9) (UGT1-09) (UGT1.9) (UDP-glucuronosyltransferase 1-I) (UGT-1I) (UGT1I) (lugP4)	UGT1A9 GNT1 UGT1	Homo sapiens (Human)	530	FUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:15470161, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:19545173). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:20610558). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212). {ECO:0000269|PubMed:12181437, ECO:0000269|PubMed:15470161, ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18052087, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:19545173, ECO:0000269|PubMed:20610558}.; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558}.	MISCELLANEOUS: UGT1A9 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity. {ECO:0000269|PubMed:18004212}.	cellular glucuronidation [GO:0052695]; flavone metabolic process [GO:0051552]; flavonoid glucuronidation [GO:0052696]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; retinoic acid metabolic process [GO:0042573]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]; cellular glucuronidation [GO:0052695]; flavone metabolic process [GO:0051552]; flavonoid glucuronidation [GO:0052696]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; retinoic acid metabolic process [GO:0042573]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17179145}; Single-pass membrane protein {ECO:0000255}.
O60658	reviewed	PDE8A_HUMAN	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)	PDE8A	Homo sapiens (Human)	829	FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). {ECO:0000269|PubMed:18983167, ECO:0000269|PubMed:23509299}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cAMP catabolic process [GO:0006198]; cellular response to epidermal growth factor stimulus [GO:0071364]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; cAMP catabolic process [GO:0006198]; cellular response to epidermal growth factor stimulus [GO:0071364]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]	
O60662	reviewed	KLH41_HUMAN	Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin)	KLHL41 KBTBD10 KRP1	Homo sapiens (Human)	606	FUNCTION: Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. {ECO:0000250|UniProtKB:A2AUC9}.		myofibril assembly [GO:0030239]; protein ubiquitination [GO:0016567]; pseudopodium assembly [GO:0031269]; regulation of myoblast differentiation [GO:0045661]; regulation of myoblast proliferation [GO:2000291]; regulation of skeletal muscle cell differentiation [GO:2001014]; skeletal muscle cell differentiation [GO:0035914]; striated muscle contraction [GO:0006941]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; M band [GO:0031430]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; ruffle [GO:0001726]; sarcoplasmic reticulum membrane [GO:0033017]		Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; M band [GO:0031430]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; ruffle [GO:0001726]; sarcoplasmic reticulum membrane [GO:0033017]; myofibril assembly [GO:0030239]; protein ubiquitination [GO:0016567]; pseudopodium assembly [GO:0031269]; regulation of myoblast differentiation [GO:0045661]; regulation of myoblast proliferation [GO:2000291]; regulation of skeletal muscle cell differentiation [GO:2001014]; skeletal muscle cell differentiation [GO:0035914]; striated muscle contraction [GO:0006941]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19424503}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A2AUC9}. Cell projection, pseudopodium {ECO:0000250|UniProtKB:Q9ER30}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9ER30}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:A2AUC9}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:24268659}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24268659}. Note=Predominantly cytoplasmic but can colocalize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia. {ECO:0000269|PubMed:19424503}.
O60663	reviewed	LMX1B_HUMAN	LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B)	LMX1B	Homo sapiens (Human)	402	FUNCTION: Transcription factor involved in the regulation of podocyte-expressed genes (PubMed:24042019, PubMed:28059119). Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. {ECO:0000269|PubMed:24042019, ECO:0000269|PubMed:28059119}.		dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral pattern formation [GO:0009953]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral pattern formation [GO:0009953]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
O60664	reviewed	PLIN3_HUMAN	Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17)	PLIN3 M6PRBP1 TIP47	Homo sapiens (Human)	434	FUNCTION: Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}.		cellular response to glucose starvation [GO:0042149]; lipid droplet disassembly [GO:1905691]; lipid storage [GO:0019915]; positive regulation of sequestering of triglyceride [GO:0010890]; vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; membrane [GO:0016020]; transport vesicle [GO:0030133]	cadherin binding [GO:0045296]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; membrane [GO:0016020]; transport vesicle [GO:0030133]; cadherin binding [GO:0045296]; cellular response to glucose starvation [GO:0042149]; lipid droplet disassembly [GO:1905691]; lipid storage [GO:0019915]; positive regulation of sequestering of triglyceride [GO:0010890]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:15545278, ECO:0000269|PubMed:34077757}. Endosome membrane {ECO:0000269|PubMed:15545278}; Peripheral membrane protein {ECO:0000269|PubMed:15545278}; Cytoplasmic side {ECO:0000269|PubMed:15545278}. Cytoplasm {ECO:0000269|PubMed:15545278, ECO:0000269|PubMed:26357594, ECO:0000269|PubMed:9590177}. Note=Membrane associated on endosomes (PubMed:15545278). Detected in the envelope and the core of lipid bodies and in lipid sails (PubMed:15545278). {ECO:0000269|PubMed:15545278}.
O60667	reviewed	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 (IgM Fc fragment receptor) (Regulator of Fas-induced apoptosis Toso)	FCMR FAIM3 TOSO	Homo sapiens (Human)	390	FUNCTION: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. {ECO:0000269|PubMed:9586636}.	MISCELLANEOUS: 'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and eternal youth.	cellular defense response [GO:0006968]; immune system process [GO:0002376]; negative regulation of apoptotic process [GO:0043066]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; cellular defense response [GO:0006968]; immune system process [GO:0002376]; negative regulation of apoptotic process [GO:0043066]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000269|PubMed:21908424}; Single-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:21908424}. Note=Detected in the serum. {ECO:0000269|PubMed:21908424}.
O60669	reviewed	MOT2_HUMAN	Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)	SLC16A7 MCT2	Homo sapiens (Human)	478	FUNCTION: Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:9786900, PubMed:32415067). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067). {ECO:0000269|PubMed:32415067, ECO:0000269|PubMed:9786900}.		lactate transmembrane transport [GO:0035873]; monocarboxylic acid transport [GO:0015718]; plasma membrane lactate transport [GO:0035879]; pyruvate transmembrane transport [GO:1901475]; transport across blood-brain barrier [GO:0150104]	basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nucleoplasm [GO:0005654]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]	identical protein binding [GO:0042802]; lactate transmembrane transporter activity [GO:0015129]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; pyruvate secondary active transmembrane transporter activity [GO:0005477]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293]	basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nucleoplasm [GO:0005654]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; identical protein binding [GO:0042802]; lactate transmembrane transporter activity [GO:0015129]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; pyruvate secondary active transmembrane transporter activity [GO:0005477]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293]; lactate transmembrane transport [GO:0035873]; monocarboxylic acid transport [GO:0015718]; plasma membrane lactate transport [GO:0035879]; pyruvate transmembrane transport [GO:1901475]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:32415067}; Multi-pass membrane protein {ECO:0000269|PubMed:32415067}. Basolateral cell membrane {ECO:0000250|UniProtKB:P53988}; Multi-pass membrane protein {ECO:0000269|PubMed:32415067}. Cytoplasm {ECO:0000250|UniProtKB:O70451}. Note=Requires the ancillary protein, EMB for plasma membrane localization (By similarity). Colocalizes with BSG in spermatozoa. Detected in the cytoplasm of Sertoli cells (By similarity). {ECO:0000250|UniProtKB:O70451, ECO:0000250|UniProtKB:Q63344}.
O60671	reviewed	RAD1_HUMAN	Cell cycle checkpoint protein RAD1 (hRAD1) (EC 3.1.11.2) (DNA repair exonuclease rad1 homolog) (Rad1-like DNA damage checkpoint protein)	RAD1 REC1	Homo sapiens (Human)	282	FUNCTION: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799). {ECO:0000269|PubMed:10846170, ECO:0000269|PubMed:10884395, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:15314187, ECO:0000269|PubMed:15556996, ECO:0000269|PubMed:15871698, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:9660799}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; meiotic recombination checkpoint signaling [GO:0051598]; substantia nigra development [GO:0021762]	checkpoint clamp complex [GO:0030896]; chromosome [GO:0005694]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5' exonuclease activity [GO:0008408]; damaged DNA binding [GO:0003684]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]	checkpoint clamp complex [GO:0030896]; chromosome [GO:0005694]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5' exonuclease activity [GO:0008408]; damaged DNA binding [GO:0003684]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; meiotic recombination checkpoint signaling [GO:0051598]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9716408}.
O60673	reviewed	REV3L_HUMAN	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3)	REV3L POLZ REV3	Homo sapiens (Human)	3130	FUNCTION: Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}.		DNA-templated DNA replication [GO:0006261]; double-strand break repair via homologous recombination [GO:0000724]; error-prone translesion synthesis [GO:0042276]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; zeta DNA polymerase complex [GO:0016035]	4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; zeta DNA polymerase complex [GO:0016035]; 4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via homologous recombination [GO:0000724]; error-prone translesion synthesis [GO:0042276]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O60674	reviewed	JAK2_HUMAN	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)	JAK2	Homo sapiens (Human)	1132	FUNCTION: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). {ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:21368206, ECO:0000269|PubMed:21423214, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:9618263}.		actin filament polymerization [GO:0030041]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097296]; activation of Janus kinase activity [GO:0042976]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; axon regeneration [GO:0031103]; cell differentiation [GO:0030154]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to interleukin-3 [GO:0036016]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; collagen-activated signaling pathway [GO:0038065]; cytokine-mediated signaling pathway [GO:0019221]; enzyme-linked receptor protein signaling pathway [GO:0007167]; erythrocyte differentiation [GO:0030218]; extrinsic apoptotic signaling pathway [GO:0097191]; G protein-coupled receptor signaling pathway [GO:0007186]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; growth hormone receptor signaling pathway [GO:0060396]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; immune response [GO:0006955]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-35-mediated signaling pathway [GO:0070757]; interleukin-5-mediated signaling pathway [GO:0038043]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; mammary gland epithelium development [GO:0061180]; mesoderm development [GO:0007498]; microglial cell activation [GO:0001774]; mineralocorticoid receptor signaling pathway [GO:0031959]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of DNA binding [GO:0043392]; negative regulation of neuron apoptotic process [GO:0043524]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [GO:1902728]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of leukocyte proliferation [GO:0070665]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; post-embryonic hemopoiesis [GO:0035166]; post-translational protein modification [GO:0043687]; programmed cell death induced by symbiont [GO:0034050]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of postsynapse to nucleus signaling pathway [GO:1905539]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; response to amine [GO:0014075]; response to antibiotic [GO:0046677]; response to hydroperoxide [GO:0033194]; response to interleukin-12 [GO:0070671]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type II interferon-mediated signaling pathway [GO:0060333]; tyrosine phosphorylation of STAT protein [GO:0007260]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; euchromatin [GO:0000791]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	acetylcholine receptor binding [GO:0033130]; ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; heme binding [GO:0020037]; histone binding [GO:0042393]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; interleukin-12 receptor binding [GO:0005143]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; peptide hormone receptor binding [GO:0051428]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; type 1 angiotensin receptor binding [GO:0031702]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; euchromatin [GO:0000791]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; acetylcholine receptor binding [GO:0033130]; ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; heme binding [GO:0020037]; histone binding [GO:0042393]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; interleukin-12 receptor binding [GO:0005143]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; peptide hormone receptor binding [GO:0051428]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; type 1 angiotensin receptor binding [GO:0031702]; actin filament polymerization [GO:0030041]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097296]; activation of Janus kinase activity [GO:0042976]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; axon regeneration [GO:0031103]; cell differentiation [GO:0030154]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to interleukin-3 [GO:0036016]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; collagen-activated signaling pathway [GO:0038065]; cytokine-mediated signaling pathway [GO:0019221]; enzyme-linked receptor protein signaling pathway [GO:0007167]; erythrocyte differentiation [GO:0030218]; extrinsic apoptotic signaling pathway [GO:0097191]; G protein-coupled receptor signaling pathway [GO:0007186]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; growth hormone receptor signaling pathway [GO:0060396]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; immune response [GO:0006955]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-35-mediated signaling pathway [GO:0070757]; interleukin-5-mediated signaling pathway [GO:0038043]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; mammary gland epithelium development [GO:0061180]; mesoderm development [GO:0007498]; microglial cell activation [GO:0001774]; mineralocorticoid receptor signaling pathway [GO:0031959]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of DNA binding [GO:0043392]; negative regulation of neuron apoptotic process [GO:0043524]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [GO:1902728]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of leukocyte proliferation [GO:0070665]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; post-embryonic hemopoiesis [GO:0035166]; post-translational protein modification [GO:0043687]; programmed cell death induced by symbiont [GO:0034050]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of postsynapse to nucleus signaling pathway [GO:1905539]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; response to amine [GO:0014075]; response to antibiotic [GO:0046677]; response to hydroperoxide [GO:0033194]; response to interleukin-12 [GO:0070671]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type II interferon-mediated signaling pathway [GO:0060333]; tyrosine phosphorylation of STAT protein [GO:0007260]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19783980}. Nucleus {ECO:0000269|PubMed:19783980}.
O60675	reviewed	MAFK_HUMAN	Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit)	MAFK	Homo sapiens (Human)	156	FUNCTION: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9150357, PubMed:8932385). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357). {ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9150357}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
O60678	reviewed	ANM3_HUMAN	Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3)	PRMT3 HRMT1L3	Homo sapiens (Human)	531	FUNCTION: Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (Probable). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (PubMed:33495566). {ECO:0000269|PubMed:33495566, ECO:0000305|PubMed:33495566}.		methylation [GO:0032259]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of retinoic acid biosynthetic process [GO:1900053]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; ribosome binding [GO:0043022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; ribosome binding [GO:0043022]; methylation [GO:0032259]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of retinoic acid biosynthetic process [GO:1900053]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9642256}.
O60682	reviewed	MUSC_HUMAN	Musculin (Activated B-cell factor 1) (ABF-1) (Class A basic helix-loop-helix protein 22) (bHLHa22)	MSC ABF1 BHLHA22	Homo sapiens (Human)	206	FUNCTION: Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.		branchiomeric skeletal muscle development [GO:0014707]; cardiac conduction system development [GO:0003161]; cellular response to leukemia inhibitory factor [GO:1990830]; diaphragm development [GO:0060539]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal muscle tissue development [GO:0007519]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; branchiomeric skeletal muscle development [GO:0014707]; cardiac conduction system development [GO:0003161]; cellular response to leukemia inhibitory factor [GO:1990830]; diaphragm development [GO:0060539]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Nucleus.
O60683	reviewed	PEX10_HUMAN	Peroxisome biogenesis factor 10 (EC 2.3.2.27) (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69)	PEX10 RNF69	Homo sapiens (Human)	326	FUNCTION: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (PubMed:24662292). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity). {ECO:0000250|UniProtKB:Q05568, ECO:0000269|PubMed:24662292}.		cellular response to reactive oxygen species [GO:0034614]; peroxisome organization [GO:0007031]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein ubiquitination [GO:0016567]	peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	protein transmembrane transporter activity [GO:0008320]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein transmembrane transporter activity [GO:0008320]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; cellular response to reactive oxygen species [GO:0034614]; peroxisome organization [GO:0007031]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:9922452}; Multi-pass membrane protein {ECO:0000255}.
O60684	reviewed	IMA7_HUMAN	Importin subunit alpha-7 (Karyopherin subunit alpha-6)	KPNA6 IPOA7	Homo sapiens (Human)	536	FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}.		entry of viral genome into host nucleus through nuclear pore complex via importin [GO:0075506]; maternal process involved in female pregnancy [GO:0060135]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of viral life cycle [GO:1903902]; protein import into nucleus [GO:0006606]; transcription by RNA polymerase II [GO:0006366]; viral genome replication [GO:0019079]	cytosol [GO:0005829]; host cell [GO:0043657]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]	cytosol [GO:0005829]; host cell [GO:0043657]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; entry of viral genome into host nucleus through nuclear pore complex via importin [GO:0075506]; maternal process involved in female pregnancy [GO:0060135]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of viral life cycle [GO:1903902]; protein import into nucleus [GO:0006606]; transcription by RNA polymerase II [GO:0006366]; viral genome replication [GO:0019079]	
O60687	reviewed	SRPX2_HUMAN	Sushi repeat-containing protein SRPX2 (Sushi-repeat protein upregulated in leukemia)	SRPX2 SRPUL	Homo sapiens (Human)	465	FUNCTION: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development. {ECO:0000269|PubMed:16497722, ECO:0000269|PubMed:18718938, ECO:0000269|PubMed:19065654, ECO:0000269|PubMed:24179158}.		angiogenesis [GO:0001525]; cell motility [GO:0048870]; cell-cell adhesion [GO:0098609]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of synapse assembly [GO:0051965]; regulation of phosphorylation [GO:0042325]; vocalization behavior [GO:0071625]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; excitatory synapse [GO:0060076]; extracellular space [GO:0005615]; synaptic membrane [GO:0097060]	hepatocyte growth factor binding [GO:0036458]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; excitatory synapse [GO:0060076]; extracellular space [GO:0005615]; synaptic membrane [GO:0097060]; hepatocyte growth factor binding [GO:0036458]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; angiogenesis [GO:0001525]; cell motility [GO:0048870]; cell-cell adhesion [GO:0098609]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of synapse assembly [GO:0051965]; regulation of phosphorylation [GO:0042325]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22242148}. Cytoplasm. Cell surface. Synapse {ECO:0000250}.
O60701	reviewed	UGDH_HUMAN	UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22)	UGDH	Homo sapiens (Human)	494	FUNCTION: Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21961565, PubMed:21502315, PubMed:23106432, PubMed:22123821, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}.		carbohydrate metabolic process [GO:0005975]; chondroitin sulfate biosynthetic process [GO:0030206]; gastrulation with mouth forming second [GO:0001702]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; neuron development [GO:0048666]; protein hexamerization [GO:0034214]; UDP-glucuronate biosynthetic process [GO:0006065]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979]; carbohydrate metabolic process [GO:0005975]; chondroitin sulfate biosynthetic process [GO:0030206]; gastrulation with mouth forming second [GO:0001702]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; neuron development [GO:0048666]; protein hexamerization [GO:0034214]; UDP-glucuronate biosynthetic process [GO:0006065]	
O60704	reviewed	TPST2_HUMAN	Protein-tyrosine sulfotransferase 2 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 2) (TPST-2)	TPST2	Homo sapiens (Human)	377	FUNCTION: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. {ECO:0000269|PubMed:9733778}.	MISCELLANEOUS: Substrate peptides must be flexible in order to adopt an L-shaped conformation in the deep binding cleft.	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; peptidyl-tyrosine sulfation [GO:0006478]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	protein homodimerization activity [GO:0042803]; protein-tyrosine sulfotransferase activity [GO:0008476]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; protein homodimerization activity [GO:0042803]; protein-tyrosine sulfotransferase activity [GO:0008476]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; peptidyl-tyrosine sulfation [GO:0006478]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:25660941}; Single-pass type II membrane protein {ECO:0000269|PubMed:25660941}.
O60706	reviewed	ABCC9_HUMAN	ATP-binding cassette sub-family C member 9 (Sulfonylurea receptor 2)	ABCC9 SUR2	Homo sapiens (Human)	1549	FUNCTION: Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. {ECO:0000269|PubMed:9831708}.	MISCELLANEOUS: May contribute to the regulation of sleep duration. An intronic variant of this gene may account for about 5% of the variation of sleep duration between individuals (PubMed:22105623). Sleep duration is influenced both by environmental and genetic factors, with an estimated heritability of about 40%. Numerous genes are expected to contribute to the regulation of sleep duration. {ECO:0000305|PubMed:22105623}.	action potential [GO:0001508]; cardiac conduction [GO:0061337]; cardiac muscle cell contraction [GO:0086003]; coronary vasculature development [GO:0060976]; defense response to virus [GO:0051607]; fibroblast proliferation [GO:0048144]; heart morphogenesis [GO:0003007]; inorganic cation transmembrane transport [GO:0098662]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of blood pressure [GO:0045776]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; response to ATP [GO:0033198]; response to xenobiotic stimulus [GO:0009410]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	inward rectifying potassium channel [GO:0008282]; membrane [GO:0016020]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; sarcomere [GO:0030017]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; ATPase-coupled transmembrane transporter activity [GO:0042626]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; sulfonylurea receptor activity [GO:0008281]; transmembrane transporter binding [GO:0044325]	inward rectifying potassium channel [GO:0008282]; membrane [GO:0016020]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; sarcomere [GO:0030017]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; ATPase-coupled transmembrane transporter activity [GO:0042626]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; sulfonylurea receptor activity [GO:0008281]; transmembrane transporter binding [GO:0044325]; action potential [GO:0001508]; cardiac conduction [GO:0061337]; cardiac muscle cell contraction [GO:0086003]; coronary vasculature development [GO:0060976]; defense response to virus [GO:0051607]; fibroblast proliferation [GO:0048144]; heart morphogenesis [GO:0003007]; inorganic cation transmembrane transport [GO:0098662]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of blood pressure [GO:0045776]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; response to ATP [GO:0033198]; response to xenobiotic stimulus [GO:0009410]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
O60711	reviewed	LPXN_HUMAN	Leupaxin	LPXN LDLP	Homo sapiens (Human)	386	FUNCTION: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}.		cell adhesion [GO:0007155]; endothelial cell migration [GO:0043542]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cell adhesion [GO:0007162]; protein-containing complex assembly [GO:0065003]; regulation of cell adhesion mediated by integrin [GO:0033628]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]	metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; cell adhesion [GO:0007155]; endothelial cell migration [GO:0043542]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cell adhesion [GO:0007162]; protein-containing complex assembly [GO:0065003]; regulation of cell adhesion mediated by integrin [GO:0033628]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin.
O60716	reviewed	CTND1_HUMAN	Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))	CTNND1 KIAA0384	Homo sapiens (Human)	968	FUNCTION: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349}.		cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cytoplasmic sequestering of protein [GO:0051220]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein stabilization [GO:0050821]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; Wnt signaling pathway [GO:0016055]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; presynaptic active zone cytoplasmic component [GO:0098831]; Schaffer collateral - CA1 synapse [GO:0098685]; zonula adherens [GO:0005915]	beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; protein tyrosine kinase binding [GO:1990782]; signaling receptor binding [GO:0005102]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; presynaptic active zone cytoplasmic component [GO:0098831]; Schaffer collateral - CA1 synapse [GO:0098685]; zonula adherens [GO:0005915]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; protein tyrosine kinase binding [GO:1990782]; signaling receptor binding [GO:0005102]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cytoplasmic sequestering of protein [GO:0051220]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein stabilization [GO:0050821]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:11896187}. Cytoplasm {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}. Nucleus {ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:17115030}. Cell membrane {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Isoforms 4A and 1AB are excluded from the nucleus (PubMed:11896187). {ECO:0000250|UniProtKB:P30999, ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}.; SUBCELLULAR LOCATION: [Isoform 1A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 2A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 3A]: Nucleus {ECO:0000269|PubMed:11896187}.
O60721	reviewed	NCKX1_HUMAN	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger) (Solute carrier family 24 member 1)	SLC24A1 KIAA0702 NCKX1	Homo sapiens (Human)	1099	FUNCTION: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:26631410). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness (PubMed:20850105). Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (PubMed:20850105). {ECO:0000269|PubMed:20850105, ECO:0000269|PubMed:26631410}.		calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; response to light intensity [GO:0009642]; sodium ion transmembrane transport [GO:0035725]; visual perception [GO:0007601]	cell surface [GO:0009986]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; outer membrane [GO:0019867]; plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]	cell surface [GO:0009986]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; outer membrane [GO:0019867]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; response to light intensity [GO:0009642]; sodium ion transmembrane transport [GO:0035725]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26631410}; Multi-pass membrane protein {ECO:0000255}.
O60725	reviewed	ICMT_HUMAN	Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT)	ICMT PCCMT	Homo sapiens (Human)	284	FUNCTION: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. {ECO:0000269|PubMed:9614111}.		C-terminal protein methylation [GO:0006481]; protein modification process [GO:0036211]; protein targeting to membrane [GO:0006612]; S-adenosylhomocysteine metabolic process [GO:0046498]; S-adenosylmethioninamine metabolic process [GO:0046499]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	protein C-terminal carboxyl O-methyltransferase activity [GO:0003880]; protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity [GO:0004671]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; protein C-terminal carboxyl O-methyltransferase activity [GO:0003880]; protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity [GO:0004671]; C-terminal protein methylation [GO:0006481]; protein modification process [GO:0036211]; protein targeting to membrane [GO:0006612]; S-adenosylhomocysteine metabolic process [GO:0046498]; S-adenosylmethioninamine metabolic process [GO:0046499]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19158273, ECO:0000269|PubMed:9614111}; Multi-pass membrane protein {ECO:0000269|PubMed:19158273}.
O60729	reviewed	CC14B_HUMAN	Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B)	CDC14B	Homo sapiens (Human)	498	FUNCTION: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. {ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:9367992}.		cilium assembly [GO:0060271]; DNA repair [GO:0006281]; microtubule cytoskeleton organization [GO:0000226]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of cytokinesis [GO:0032467]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein dephosphorylation [GO:0006470]; regulation of exit from mitosis [GO:0007096]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cilium assembly [GO:0060271]; DNA repair [GO:0006281]; microtubule cytoskeleton organization [GO:0000226]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of cytokinesis [GO:0032467]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein dephosphorylation [GO:0006470]; regulation of exit from mitosis [GO:0007096]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.
O60733	reviewed	PLPL9_HUMAN	85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (2-lysophosphatidylcholine acylhydrolase) (EC 3.1.1.5) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9)	PLA2G6 PLPLA9	Homo sapiens (Human)	806	FUNCTION: Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:9417066, PubMed:10092647, PubMed:10336645, PubMed:20886109). Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position (PubMed:10092647, PubMed:10336645, PubMed:20886109). Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity) (PubMed:20886109). Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content (PubMed:23533611). Preferentially hydrolyzes oxidized polyunsaturated fatty acyl chains from cardiolipins, yielding monolysocardiolipins that can be reacylated with unoxidized fatty acyls to regenerate native cardiolipin species (By similarity). Hydrolyzes oxidized glycerophosphoethanolamines present in pancreatic islets, releasing oxidized polyunsaturated fatty acids such as hydroxyeicosatetraenoates (HETEs) (By similarity). Has thioesterase activity toward fatty-acyl CoA releasing CoA-SH known to facilitate fatty acid transport and beta-oxidation in mitochondria particularly in skeletal muscle (PubMed:20886109). Plays a role in regulation of membrane dynamics and homeostasis. Selectively hydrolyzes sn-2 arachidonoyl group in plasmalogen phospholipids, structural components of lipid rafts and myelin (By similarity). Regulates F-actin polymerization at the pseudopods, which is required for both speed and directionality of MCP1/CCL2-induced monocyte chemotaxis (PubMed:18208975). Targets membrane phospholipids to produce potent lipid signaling messengers. Generates lysophosphatidate (LPA, 1-acyl-glycerol-3-phosphate), which acts via G-protein receptors in various cell types (By similarity). Has phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent pro-inflammatory signaling lipid (By similarity). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion (By similarity). {ECO:0000250|UniProtKB:A0A3L7I2I8, ECO:0000250|UniProtKB:P97570, ECO:0000250|UniProtKB:P97819, ECO:0000269|PubMed:10092647, ECO:0000269|PubMed:10336645, ECO:0000269|PubMed:18208975, ECO:0000269|PubMed:20886109, ECO:0000269|PubMed:23533611, ECO:0000269|PubMed:9417066}.; FUNCTION: [Isoform Ankyrin-iPLA2-1]: Lacks the catalytic domain and may act as a negative regulator of the catalytically active isoforms. {ECO:0000269|PubMed:9417066}.; FUNCTION: [Isoform Ankyrin-iPLA2-2]: Lacks the catalytic domain and may act as a negative regulator of the catalytically active isoforms. {ECO:0000269|PubMed:9417066}.		antibacterial humoral response [GO:0019731]; cardiolipin acyl-chain remodeling [GO:0035965]; cardiolipin biosynthetic process [GO:0032049]; chemotaxis [GO:0006935]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338]; platelet activating factor metabolic process [GO:0046469]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	cytosol [GO:0005829]; extracellular space [GO:0005615]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium-independent phospholipase A2 activity [GO:0047499]; calmodulin binding [GO:0005516]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; lysophospholipase activity [GO:0004622]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; phosphatidyl phospholipase B activity [GO:0102545]; phospholipase A2 activity [GO:0004623]; serine hydrolase activity [GO:0017171]	cytosol [GO:0005829]; extracellular space [GO:0005615]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium-independent phospholipase A2 activity [GO:0047499]; calmodulin binding [GO:0005516]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; lysophospholipase activity [GO:0004622]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; phosphatidyl phospholipase B activity [GO:0102545]; phospholipase A2 activity [GO:0004623]; serine hydrolase activity [GO:0017171]; antibacterial humoral response [GO:0019731]; cardiolipin acyl-chain remodeling [GO:0035965]; cardiolipin biosynthetic process [GO:0032049]; chemotaxis [GO:0006935]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338]; platelet activating factor metabolic process [GO:0046469]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18208975}. Cell membrane {ECO:0000269|PubMed:18208975}. Mitochondrion {ECO:0000250|UniProtKB:P97819}. Cell projection, pseudopodium {ECO:0000269|PubMed:18208975}. Note=Recruited to the membrane-enriched pseudopods upon MCP1/CCL2 stimulation in monocytes. {ECO:0000269|PubMed:18208975}.
O60741	reviewed	HCN1_HUMAN	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)	HCN1 BCNG1	Homo sapiens (Human)	890	FUNCTION: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. {ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:29936235, ECO:0000269|PubMed:30351409}.		apical protein localization [GO:0045176]; cellular response to cAMP [GO:0071320]; general adaptation syndrome, behavioral process [GO:0051867]; neuronal action potential [GO:0019228]; potassium ion transmembrane transport [GO:0071805]; protein homotetramerization [GO:0051289]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; retinal cone cell development [GO:0046549]; sodium ion transmembrane transport [GO:0035725]	axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; HCN channel complex [GO:0098855]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]	cAMP binding [GO:0030552]; identical protein binding [GO:0042802]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential [GO:0140232]; potassium channel activity [GO:0005267]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]	axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; HCN channel complex [GO:0098855]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]; cAMP binding [GO:0030552]; identical protein binding [GO:0042802]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential [GO:0140232]; potassium channel activity [GO:0005267]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]; apical protein localization [GO:0045176]; cellular response to cAMP [GO:0071320]; general adaptation syndrome, behavioral process [GO:0051867]; neuronal action potential [GO:0019228]; potassium ion transmembrane transport [GO:0071805]; protein homotetramerization [GO:0051289]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; retinal cone cell development [GO:0046549]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:30351409}; Multi-pass membrane protein {ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:30351409}.
O60749	reviewed	SNX2_HUMAN	Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9)	SNX2 TRG9	Homo sapiens (Human)	519	FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:20138391, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:23085988, ECO:0000303|PubMed:16179610}.		early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886]; lamellipodium morphogenesis [GO:0072673]; retrograde transport, endosome to Golgi [GO:0042147]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lamellipodium [GO:0030027]; lysosome [GO:0005764]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]	cadherin binding [GO:0045296]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transferrin receptor binding [GO:1990459]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lamellipodium [GO:0030027]; lysosome [GO:0005764]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; cadherin binding [GO:0045296]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transferrin receptor binding [GO:1990459]; early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886]; lamellipodium morphogenesis [GO:0072673]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}; Peripheral membrane protein {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}; Cytoplasmic side {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (PubMed:20604901). {ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:20604901}.
O60755	reviewed	GALR3_HUMAN	Galanin receptor type 3 (GAL3-R) (GALR-3)	GALR3 GALNR3	Homo sapiens (Human)	368	FUNCTION: Receptor for the hormone galanin (PubMed:25691535). Receptor for the hormone spexin-1 (PubMed:24517231). {ECO:0000269|PubMed:24517231, ECO:0000269|PubMed:25691535, ECO:0000269|PubMed:9722565, ECO:0000269|PubMed:9832121}.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; galanin-activated signaling pathway [GO:0090663]; learning or memory [GO:0007611]; neuropeptide signaling pathway [GO:0007218]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cilium [GO:0005929]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; synapse [GO:0045202]	galanin receptor activity [GO:0004966]; peptide hormone binding [GO:0017046]	cilium [GO:0005929]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; synapse [GO:0045202]; galanin receptor activity [GO:0004966]; peptide hormone binding [GO:0017046]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; galanin-activated signaling pathway [GO:0090663]; learning or memory [GO:0007611]; neuropeptide signaling pathway [GO:0007218]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O60759	reviewed	CYTIP_HUMAN	Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein)	CYTIP PSCDBP	Homo sapiens (Human)	359	FUNCTION: By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.		regulation of cell adhesion [GO:0030155]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; nucleoplasm [GO:0005654]		cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; nucleoplasm [GO:0005654]; regulation of cell adhesion [GO:0030155]	SUBCELLULAR LOCATION: Cytoplasm. Early endosome. Note=Recruited from the cytosol to endosomes by SNX27.
O60760	reviewed	HPGDS_HUMAN	Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase)	HPGDS GSTS PGDS PTGDS2	Homo sapiens (Human)	199	FUNCTION: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12244105, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:19939518, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.		locomotory behavior [GO:0007626]; negative regulation of male germ cell proliferation [GO:2000255]; prostaglandin biosynthetic process [GO:0001516]; prostaglandin metabolic process [GO:0006693]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	calcium ion binding [GO:0005509]; glutathione transferase activity [GO:0004364]; magnesium ion binding [GO:0000287]; prostaglandin-D synthase activity [GO:0004667]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; calcium ion binding [GO:0005509]; glutathione transferase activity [GO:0004364]; magnesium ion binding [GO:0000287]; prostaglandin-D synthase activity [GO:0004667]; protein homodimerization activity [GO:0042803]; locomotory behavior [GO:0007626]; negative regulation of male germ cell proliferation [GO:2000255]; prostaglandin biosynthetic process [GO:0001516]; prostaglandin metabolic process [GO:0006693]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9353279}.
O60762	reviewed	DPM1_HUMAN	Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) (Dolichol-phosphate mannose synthase subunit 1) (DPM synthase subunit 1) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 1) (Mannose-P-dolichol synthase subunit 1) (MPD synthase subunit 1)	DPM1	Homo sapiens (Human)	260	FUNCTION: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. {ECO:0000269|PubMed:10835346}.		dolichol metabolic process [GO:0019348]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; GDP-mannose metabolic process [GO:0019673]; GPI anchor biosynthetic process [GO:0006506]; protein mannosylation [GO:0035268]; protein N-linked glycosylation via asparagine [GO:0018279]; protein O-linked mannosylation [GO:0035269]	dolichol-phosphate-mannose synthase complex [GO:0033185]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]	alcohol binding [GO:0043178]; dolichyl-phosphate beta-D-mannosyltransferase activity [GO:0004582]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]	dolichol-phosphate-mannose synthase complex [GO:0033185]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; alcohol binding [GO:0043178]; dolichyl-phosphate beta-D-mannosyltransferase activity [GO:0004582]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]; dolichol metabolic process [GO:0019348]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; GDP-mannose metabolic process [GO:0019673]; GPI anchor biosynthetic process [GO:0006506]; protein mannosylation [GO:0035268]; protein N-linked glycosylation via asparagine [GO:0018279]; protein O-linked mannosylation [GO:0035269]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000305|PubMed:10835346}.
O60763	reviewed	USO1_HUMAN	General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein)	USO1 VDP	Homo sapiens (Human)	962	FUNCTION: General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi vesicle docking [GO:0048211]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; regulation of cellular response to insulin stimulus [GO:1900076]; secretory granule localization [GO:0032252]; small GTPase mediated signal transduction [GO:0007264]; transcytosis [GO:0045056]; vesicle fusion with Golgi apparatus [GO:0048280]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle [GO:0030133]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle [GO:0030133]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi vesicle docking [GO:0048211]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; regulation of cellular response to insulin stimulus [GO:1900076]; secretory granule localization [GO:0032252]; small GTPase mediated signal transduction [GO:0007264]; transcytosis [GO:0045056]; vesicle fusion with Golgi apparatus [GO:0048280]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:9478999}. Golgi apparatus membrane {ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:9478999}; Peripheral membrane protein {ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:9478999}. Note=Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes. {ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:9478999}.
O60779	reviewed	S19A2_HUMAN	Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1)	SLC19A2 THT1 TRMA	Homo sapiens (Human)	497	FUNCTION: High-affinity transporter for the intake of thiamine (PubMed:10542220, PubMed:10391222, PubMed:33008889, PubMed:35512554, PubMed:35724964). Mediates H(+)-dependent pyridoxine transport (PubMed:33008889, PubMed:35512554, PubMed:35724964). {ECO:0000269|PubMed:10391222, ECO:0000269|PubMed:10542220, ECO:0000269|PubMed:33008889, ECO:0000269|PubMed:35512554, ECO:0000269|PubMed:35724964}.		pyridoxine transport [GO:0031923]; spermatogenesis [GO:0007283]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine transmembrane transport [GO:0071934]; thiamine transport [GO:0015888]; thiamine-containing compound metabolic process [GO:0042723]; transmembrane transport [GO:0055085]	membrane [GO:0016020]; plasma membrane [GO:0005886]	folic acid transmembrane transporter activity [GO:0008517]; thiamine transmembrane transporter activity [GO:0015234]	membrane [GO:0016020]; plasma membrane [GO:0005886]; folic acid transmembrane transporter activity [GO:0008517]; thiamine transmembrane transporter activity [GO:0015234]; pyridoxine transport [GO:0031923]; spermatogenesis [GO:0007283]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine transmembrane transport [GO:0071934]; thiamine transport [GO:0015888]; thiamine-containing compound metabolic process [GO:0042723]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:10391222, ECO:0000305|PubMed:10542220}; Multi-pass membrane protein {ECO:0000255}.
O60783	reviewed	RT14_HUMAN	Small ribosomal subunit protein uS14m (28S ribosomal protein S14, mitochondrial) (MRP-S14) (S14mt)	MRPS14	Homo sapiens (Human)	128			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
O60784	reviewed	TOM1_HUMAN	Target of Myb1 membrane trafficking protein (Target of Myb protein 1)	TOM1	Homo sapiens (Human)	492	FUNCTION: Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}.		autophagosome-lysosome fusion [GO:0061909]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; positive regulation of autophagosome maturation [GO:1901098]; protein transport [GO:0015031]; regulation of endosome organization [GO:1904978]; signal transduction [GO:0007165]; substrate localization to autophagosome [GO:0061753]	azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	clathrin binding [GO:0030276]; clathrin heavy chain binding [GO:0032050]; myosin VI binding [GO:0070853]; phosphatidylinositol-5-phosphate binding [GO:0010314]; polyubiquitin modification-dependent protein binding [GO:0031593]; ubiquitin binding [GO:0043130]	azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; clathrin binding [GO:0030276]; clathrin heavy chain binding [GO:0032050]; myosin VI binding [GO:0070853]; phosphatidylinositol-5-phosphate binding [GO:0010314]; polyubiquitin modification-dependent protein binding [GO:0031593]; ubiquitin binding [GO:0043130]; autophagosome-lysosome fusion [GO:0061909]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; positive regulation of autophagosome maturation [GO:1901098]; protein transport [GO:0015031]; regulation of endosome organization [GO:1904978]; signal transduction [GO:0007165]; substrate localization to autophagosome [GO:0061753]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:14613930, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31263572}. Endosome membrane {ECO:0000269|PubMed:14613930, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31263572}; Peripheral membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582}; Peripheral membrane protein {ECO:0000305}. Note=Localized to endo/exosomal vesicles (PubMed:31263572). Enriched on signaling endosomes (PubMed:25588840). Recruited to early endosomes by TOLLIP and by PtdIns(5)P (PubMed:15047686, PubMed:25588840, PubMed:26320582). {ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31263572}.
O60806	reviewed	TBX19_HUMAN	T-box transcription factor TBX19 (T-box protein 19) (T-box factor, pituitary)	TBX19 TPIT	Homo sapiens (Human)	448	FUNCTION: Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters. {ECO:0000269|PubMed:11290323}.		anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; heart morphogenesis [GO:0003007]; mesoderm formation [GO:0001707]; pituitary gland development [GO:0021983]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; heart morphogenesis [GO:0003007]; mesoderm formation [GO:0001707]; pituitary gland development [GO:0021983]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
O60812	reviewed	HNRC1_HUMAN	Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1)	HNRNPCL1 HNRPCL1	Homo sapiens (Human)	293	FUNCTION: May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}.			nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Component of ribonucleosomes. {ECO:0000250}.
O60814	reviewed	H2B1K_HUMAN	Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1)	H2BC12 H2BFT HIRIP1 HIST1H2BK	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; killing of cells of another organism [GO:0031640]	cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; killing of cells of another organism [GO:0031640]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
O60825	reviewed	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]	PFKFB2	Homo sapiens (Human)	505	FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:11069105}.		fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]; glucose catabolic process [GO:0006007]; glycolytic process [GO:0006096]; lactate metabolic process [GO:0006089]; positive regulation of insulin secretion [GO:0032024]; response to glucose [GO:0009749]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]; protein kinase binding [GO:0019901]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; 6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]; protein kinase binding [GO:0019901]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]; glucose catabolic process [GO:0006007]; glycolytic process [GO:0006096]; lactate metabolic process [GO:0006089]; positive regulation of insulin secretion [GO:0032024]; response to glucose [GO:0009749]	
O60826	reviewed	CCD22_HUMAN	Coiled-coil domain-containing protein 22	CCDC22 CXorf37 JM1	Homo sapiens (Human)	627	FUNCTION: Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:28892079, PubMed:25355947). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). {ECO:0000269|PubMed:23563313, ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.; FUNCTION: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}.		cytoplasmic sequestering of NF-kappaB [GO:0007253]; endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; intracellular copper ion homeostasis [GO:0006878]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein transport [GO:0015031]	centrosome [GO:0005813]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]	cullin family protein binding [GO:0097602]	centrosome [GO:0005813]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; cullin family protein binding [GO:0097602]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; intracellular copper ion homeostasis [GO:0006878]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Endosome {ECO:0000305|PubMed:28892079}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26638075}.
O60828	reviewed	PQBP1_HUMAN	Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1)	PQBP1 NPW38 JM26	Homo sapiens (Human)	265	FUNCTION: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:23512658, PubMed:20410308). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437). {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:21933836, ECO:0000269|PubMed:23512658, ECO:0000269|PubMed:26046437}.		activation of innate immune response [GO:0002218]; alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; neuron projection development [GO:0031175]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type I interferon production [GO:0032481]; regulation of dendrite morphogenesis [GO:0048814]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; neuronal ribonucleoprotein granule [GO:0071598]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; ribonucleoprotein complex binding [GO:0043021]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; neuronal ribonucleoprotein granule [GO:0071598]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; ribonucleoprotein complex binding [GO:0043021]; transcription coactivator activity [GO:0003713]; activation of innate immune response [GO:0002218]; alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; neuron projection development [GO:0031175]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type I interferon production [GO:0032481]; regulation of dendrite morphogenesis [GO:0048814]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:23512658}. Nucleus speckle {ECO:0000250|UniProtKB:Q91VJ5}. Cytoplasmic granule {ECO:0000269|PubMed:21933836}. Note=Colocalizes with SRSF2 in nuclear speckles (By similarity). Colocalized with POU3F2 (PubMed:10332029). Colocalized with ATXN1 in nuclear inclusion bodies (PubMed:12062018). Localizes to cytoplasmic stress granules (PubMed:21933836). {ECO:0000250|UniProtKB:Q91VJ5, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:21933836}.
O60829	reviewed	PAGE4_HUMAN	P antigen family member 4 (PAGE-4) (G antigen family C member 1) (PAGE-1)	PAGE4 GAGEC1 JM27	Homo sapiens (Human)	102	FUNCTION: Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN (PubMed:24263171, PubMed:28289210). Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway (PubMed:21357425, PubMed:25374899, PubMed:30658679). {ECO:0000269|PubMed:21357425, ECO:0000269|PubMed:24263171, ECO:0000269|PubMed:25374899, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:30658679}.		intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; regulation of stress-activated MAPK cascade [GO:0032872]; response to starvation [GO:0042594]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; transcription coactivator activity [GO:0003713]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; regulation of stress-activated MAPK cascade [GO:0032872]; response to starvation [GO:0042594]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12489849, ECO:0000269|PubMed:24559171, ECO:0000269|PubMed:25374899}. Nucleus {ECO:0000269|PubMed:24559171}. Mitochondrion {ECO:0000269|PubMed:25374899}. Note=Translocates to mitochondria in response to stress. {ECO:0000269|PubMed:25374899}.
O60830	reviewed	TI17B_HUMAN	Mitochondrial import inner membrane translocase subunit Tim17-B	TIMM17B TIM17B JM3	Homo sapiens (Human)	172	FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.		intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]	mitochondrial inner membrane [GO:0005743]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	protein transmembrane transporter activity [GO:0008320]	mitochondrial inner membrane [GO:0005743]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; protein transmembrane transporter activity [GO:0008320]; intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
O60831	reviewed	PRAF2_HUMAN	PRA1 family protein 2	PRAF2 JM4	Homo sapiens (Human)	178	FUNCTION: May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis. {ECO:0000269|PubMed:17975142, ECO:0000269|PubMed:18395978}.		L-glutamate transmembrane transport [GO:0015813]; protein transport [GO:0015031]	endosome membrane [GO:0010008]; membrane [GO:0016020]		endosome membrane [GO:0010008]; membrane [GO:0016020]; L-glutamate transmembrane transport [GO:0015813]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000305|PubMed:17975142}; Multi-pass membrane protein {ECO:0000305|PubMed:17975142}.
O60832	reviewed	DKC1_HUMAN	H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)	DKC1 NOLA4	Homo sapiens (Human)	514	FUNCTION: [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}.		box H/ACA RNA 3'-end processing [GO:0000495]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; rRNA pseudouridine synthesis [GO:0031118]; scaRNA localization to Cajal body [GO:0090666]; snRNA pseudouridine synthesis [GO:0031120]; telomerase RNA stabilization [GO:0090669]; telomere maintenance via telomerase [GO:0007004]	box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]	box H/ACA snoRNA binding [GO:0034513]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034]	box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]; box H/ACA snoRNA binding [GO:0034513]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034]; box H/ACA RNA 3'-end processing [GO:0000495]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; rRNA pseudouridine synthesis [GO:0031118]; scaRNA localization to Cajal body [GO:0090666]; snRNA pseudouridine synthesis [GO:0031120]; telomerase RNA stabilization [GO:0090669]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleolus {ECO:0000269|PubMed:10556300, ECO:0000269|PubMed:10591218, ECO:0000269|PubMed:12429849}. Nucleus, Cajal body {ECO:0000250|UniProtKB:P40615}. Note=Also localized to Cajal bodies (coiled bodies). {ECO:0000250|UniProtKB:P40615}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:21820037}.
O60840	reviewed	CAC1F_HUMAN	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage-gated calcium channel subunit alpha Cav1.4)	CACNA1F CACNAF1	Homo sapiens (Human)	1977	FUNCTION: [Isoform 1]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization. {ECO:0000269|PubMed:27226626}.; FUNCTION: [Isoform 4]: Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exhibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations. {ECO:0000269|PubMed:27226626}.; FUNCTION: [Isoform 6]: Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exhibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations. {ECO:0000269|PubMed:27226626}.		calcium ion import across plasma membrane [GO:0098703]; detection of light stimulus involved in visual perception [GO:0050908]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; regulation of monoatomic ion transmembrane transport [GO:0034765]; visual perception [GO:0007601]	membrane [GO:0016020]; perikaryon [GO:0043204]; photoreceptor outer segment [GO:0001750]; voltage-gated calcium channel complex [GO:0005891]	high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]	membrane [GO:0016020]; perikaryon [GO:0043204]; photoreceptor outer segment [GO:0001750]; voltage-gated calcium channel complex [GO:0005891]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; calcium ion import across plasma membrane [GO:0098703]; detection of light stimulus involved in visual perception [GO:0050908]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; regulation of monoatomic ion transmembrane transport [GO:0034765]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
O60841	reviewed	IF2P_HUMAN	Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2)	EIF5B IF2 KIAA0741	Homo sapiens (Human)	1220	FUNCTION: Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}.		regulation of translational initiation [GO:0006446]; ribosome assembly [GO:0042255]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; synapse [GO:0045202]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; synapse [GO:0045202]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049]; regulation of translational initiation [GO:0006446]; ribosome assembly [GO:0042255]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q05D44}.
O60844	reviewed	ZG16_HUMAN	Zymogen granule membrane protein 16 (Zymogen granule protein 16) (hZG16) (Secretory lectin ZG16)	ZG16	Homo sapiens (Human)	167	FUNCTION: May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN. {ECO:0000269|PubMed:17307141}.		defense response to Gram-positive bacterium [GO:0050830]; protein transport [GO:0015031]; suppression of symbiont entry into host [GO:0052373]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; mucus layer [GO:0070701]; zymogen granule membrane [GO:0042589]	carbohydrate binding [GO:0030246]; peptidoglycan binding [GO:0042834]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; mucus layer [GO:0070701]; zymogen granule membrane [GO:0042589]; carbohydrate binding [GO:0030246]; peptidoglycan binding [GO:0042834]; defense response to Gram-positive bacterium [GO:0050830]; protein transport [GO:0015031]; suppression of symbiont entry into host [GO:0052373]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17307141}. Zymogen granule lumen {ECO:0000250|UniProtKB:Q8CJD3}. Golgi apparatus lumen {ECO:0000269|PubMed:17307141}.
O60858	reviewed	TRI13_HUMAN	E3 ubiquitin-protein ligase TRIM13 (EC 2.3.2.27) (B-cell chronic lymphocytic leukemia tumor suppressor Leu5) (Leukemia-associated protein 5) (Putative tumor suppressor RFP2) (RING finger protein 77) (RING-type E3 ubiquitin transferase TRIM13) (Ret finger protein 2) (Tripartite motif-containing protein 13)	TRIM13 LEU5 RFP2 RNF77	Homo sapiens (Human)	407	FUNCTION: Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor (PubMed:22178386). Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation (PubMed:28087809). Participates as well in T-cell receptor-mediated NF-kappa-B activation (PubMed:25088585). In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B (PubMed:25152375). {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386, ECO:0000269|PubMed:25088585, ECO:0000269|PubMed:25152375, ECO:0000269|PubMed:28087809}.	MISCELLANEOUS: Located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia.	anatomical structure morphogenesis [GO:0009653]; innate immune response [GO:0045087]; negative regulation of viral transcription [GO:0032897]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; perinuclear endoplasmic reticulum [GO:0097038]	transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase activity [GO:0061659]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; perinuclear endoplasmic reticulum [GO:0097038]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase activity [GO:0061659]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; anatomical structure morphogenesis [GO:0009653]; innate immune response [GO:0045087]; negative regulation of viral transcription [GO:0032897]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386, ECO:0000269|PubMed:25152375}; Single-pass membrane protein {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386}. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum.
O60861	reviewed	GAS7_HUMAN	Growth arrest-specific protein 7 (GAS-7)	GAS7 KIAA0394	Homo sapiens (Human)	476	FUNCTION: May play a role in promoting maturation and morphological differentiation of cerebellar neurons.		actin filament polymerization [GO:0030041]; neuron projection morphogenesis [GO:0048812]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; identical protein binding [GO:0042802]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; actin filament polymerization [GO:0030041]; neuron projection morphogenesis [GO:0048812]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O60869	reviewed	EDF1_HUMAN	Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1)	EDF1	Homo sapiens (Human)	148	FUNCTION: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. {ECO:0000269|PubMed:10567391, ECO:0000269|PubMed:12040021, ECO:0000269|PubMed:15112053, ECO:0000269|PubMed:9813014}.		endothelial cell differentiation [GO:0045446]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of lipid metabolic process [GO:0019216]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	calmodulin binding [GO:0005516]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; TFIID-class transcription factor complex binding [GO:0001094]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; calmodulin binding [GO:0005516]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; TFIID-class transcription factor complex binding [GO:0001094]; transcription coactivator activity [GO:0003713]; endothelial cell differentiation [GO:0045446]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of lipid metabolic process [GO:0019216]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
O60870	reviewed	KIN17_HUMAN	DNA/RNA-binding protein KIN17 (Binding to curved DNA) (KIN, antigenic determinant of recA protein homolog)	KIN BTCD KIN17	Homo sapiens (Human)	393	FUNCTION: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485, ECO:0000269|PubMed:17045609}.	MISCELLANEOUS: Recognized by antibodies directed against the RecA protein. {ECO:0000250|UniProtKB:Q8K339}.	DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; mRNA processing [GO:0006397]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; mRNA processing [GO:0006397]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. Cytoplasm {ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}.
O60879	reviewed	DIAP2_HUMAN	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2)	DIAPH2 DIA	Homo sapiens (Human)	1101	FUNCTION: Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. {ECO:0000269|PubMed:12577064}.		actin filament polymerization [GO:0030041]; female gamete generation [GO:0007292]; oogenesis [GO:0048477]	actin filament [GO:0005884]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]	actin binding [GO:0003779]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]	actin filament [GO:0005884]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; actin binding [GO:0003779]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; actin filament polymerization [GO:0030041]; female gamete generation [GO:0007292]; oogenesis [GO:0048477]	SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.
O60880	reviewed	SH21A_HUMAN	SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)	SH2D1A DSHP SAP	Homo sapiens (Human)	128	FUNCTION: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. {ECO:0000250|UniProtKB:O88890, ECO:0000269|PubMed:11806999, ECO:0000269|PubMed:12458214, ECO:0000305|PubMed:21219180}.		adaptive immune response [GO:0002250]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; humoral immune response [GO:0006959]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of immune response [GO:0050776]	cytoplasm [GO:0005737]; cytosol [GO:0005829]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; adaptive immune response [GO:0002250]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; humoral immune response [GO:0006959]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
O60882	reviewed	MMP20_HUMAN	Matrix metalloproteinase-20 (MMP-20) (EC 3.4.24.-) (Enamel metalloproteinase) (Enamelysin)	MMP20	Homo sapiens (Human)	483	FUNCTION: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. {ECO:0000269|PubMed:10922468, ECO:0000269|PubMed:9398237}.		amelogenesis [GO:0097186]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of enamel mineralization [GO:0070173]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; amelogenesis [GO:0097186]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of enamel mineralization [GO:0070173]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
O60883	reviewed	G37L1_HUMAN	G-protein coupled receptor 37-like 1 (Endothelin B receptor-like protein 2) (ETBR-LP-2)	GPR37L1 ETBRLP2	Homo sapiens (Human)	481	FUNCTION: G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity). {ECO:0000250|UniProtKB:Q99JG2, ECO:0000269|PubMed:23690594, ECO:0000269|PubMed:27072655, ECO:0000269|PubMed:28688853}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; Bergmann glial cell differentiation [GO:0060020]; cellular response to reactive oxygen species [GO:0034614]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of systemic arterial blood pressure [GO:0003085]; positive regulation of cerebellar granule cell precursor proliferation [GO:0021940]; positive regulation of MAPK cascade [GO:0043410]; smoothened signaling pathway [GO:0007224]	ciliary membrane [GO:0060170]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]; prosaposin receptor activity [GO:0036505]	ciliary membrane [GO:0060170]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]; prosaposin receptor activity [GO:0036505]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; Bergmann glial cell differentiation [GO:0060020]; cellular response to reactive oxygen species [GO:0034614]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of systemic arterial blood pressure [GO:0003085]; positive regulation of cerebellar granule cell precursor proliferation [GO:0021940]; positive regulation of MAPK cascade [GO:0043410]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28688853}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q99JG2}; Multi-pass membrane protein {ECO:0000255}. Note=Associates with the basal membrane of Bergmann glia cell primary cilia. {ECO:0000250|UniProtKB:Q99JG2}.
O60884	reviewed	DNJA2_HUMAN	DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14)	DNAJA2 CPR3 HIRIP4	Homo sapiens (Human)	412	FUNCTION: Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}.		positive regulation of cell population proliferation [GO:0008284]; protein refolding [GO:0042026]; response to heat [GO:0009408]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	ATP binding [GO:0005524]; ATPase activator activity [GO:0001671]; Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; ATP binding [GO:0005524]; ATPase activator activity [GO:0001671]; Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; positive regulation of cell population proliferation [GO:0008284]; protein refolding [GO:0042026]; response to heat [GO:0009408]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
O60885	reviewed	BRD4_HUMAN	Bromodomain-containing protein 4 (Protein HUNK1)	BRD4 HUNK1	Homo sapiens (Human)	1362	FUNCTION: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}.	MISCELLANEOUS: Some specific inhibitors of BRD4 that prevent binding to acetylated histones by binding Asn-140 and Asn-433 are promising therapeutic molecules for the treatment of leukemias. JQ1, a thieno-triazolo-1,4-diazepine derivative, and I-BET, a benzodiazepine derivative, have been tested on tumors with success (PubMed:20871596, PubMed:21068722, PubMed:21964340). Treatment with GSK1210151A (I-BET151, a I-BET derivative) has strong effets on mixed lineage leukemia and promotes myeloid differentiation and leukemia stem-cell depletion (PubMed:21964340). {ECO:0000305|PubMed:20871596, ECO:0000305|PubMed:21068722, ECO:0000305|PubMed:21964340}.; MISCELLANEOUS: [Isoform B]: Does not contain the C-terminal (CTD) region required to recruit the P-TEFb complex. {ECO:0000305}.	chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of inflammatory response [GO:0050727]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; P-TEFb complex binding [GO:0106140]; p53 binding [GO:0002039]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; P-TEFb complex binding [GO:0106140]; p53 binding [GO:0002039]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of inflammatory response [GO:0050727]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:25593309}. Chromosome {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:21890894}. Note=Associates with acetylated chromatin (PubMed:21890894, PubMed:16109376). Released from chromatin upon deacetylation of histones that can be triggered by different signals such as activation of the JNK pathway or nocodazole treatment (PubMed:21890894, PubMed:16109376). Preferentially localizes to mitotic chromosomes, while it does not localize to meiotic chromosomes (PubMed:21890894, PubMed:16109376). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:21890894}.; SUBCELLULAR LOCATION: [Isoform B]: Chromosome {ECO:0000269|PubMed:23728299}.
O60888	reviewed	CUTA_HUMAN	Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor)	CUTA ACHAP C6orf82	Homo sapiens (Human)	179	FUNCTION: May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE).		protein localization [GO:0008104]; response to metal ion [GO:0010038]	extracellular exosome [GO:0070062]; membrane [GO:0016020]	copper ion binding [GO:0005507]; enzyme binding [GO:0019899]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; copper ion binding [GO:0005507]; enzyme binding [GO:0019899]; protein localization [GO:0008104]; response to metal ion [GO:0010038]	
O60890	reviewed	OPHN1_HUMAN	Oligophrenin-1	OPHN1	Homo sapiens (Human)	802	FUNCTION: Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). {ECO:0000250}.		actin cytoskeleton organization [GO:0030036]; axon guidance [GO:0007411]; cell junction assembly [GO:0034329]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cerebellar granule cell differentiation [GO:0021707]; cerebral cortex neuron differentiation [GO:0021895]; establishment of epithelial cell apical/basal polarity [GO:0045198]; maintenance of postsynaptic specialization structure [GO:0098880]; negative regulation of proteasomal protein catabolic process [GO:1901799]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; regulation of endocytosis [GO:0030100]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle endocytosis [GO:1900242]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]; synaptic vesicle endocytosis [GO:0048488]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; terminal bouton [GO:0043195]	actin binding [GO:0003779]; GTPase activator activity [GO:0005096]; ionotropic glutamate receptor binding [GO:0035255]; phospholipid binding [GO:0005543]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; terminal bouton [GO:0043195]; actin binding [GO:0003779]; GTPase activator activity [GO:0005096]; ionotropic glutamate receptor binding [GO:0035255]; phospholipid binding [GO:0005543]; actin cytoskeleton organization [GO:0030036]; axon guidance [GO:0007411]; cell junction assembly [GO:0034329]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cerebellar granule cell differentiation [GO:0021707]; cerebral cortex neuron differentiation [GO:0021895]; establishment of epithelial cell apical/basal polarity [GO:0045198]; maintenance of postsynaptic specialization structure [GO:0098880]; negative regulation of proteasomal protein catabolic process [GO:1901799]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; regulation of endocytosis [GO:0030100]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle endocytosis [GO:1900242]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Postsynapse {ECO:0000250|UniProtKB:P0CAX5}. Presynapse {ECO:0000250|UniProtKB:P0CAX5}. Cell projection, axon {ECO:0000250|UniProtKB:P0CAX5}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P0CAX5}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99J31}. Cytoplasm {ECO:0000250|UniProtKB:Q99J31}.
O60894	reviewed	RAMP1_HUMAN	Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1)	RAMP1	Homo sapiens (Human)	148	FUNCTION: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. {ECO:0000269|PubMed:9620797}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor signaling pathway [GO:0097647]; angiogenesis [GO:0001525]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion transport [GO:0006816]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular protein transport [GO:0006886]; positive regulation of protein glycosylation [GO:0060050]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	amylin receptor complex 1 [GO:0150056]; cell surface [GO:0009986]; CGRP receptor complex [GO:1990406]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	amylin receptor activity [GO:0097643]; calcitonin gene-related peptide binding [GO:1990407]; calcitonin gene-related peptide receptor activity [GO:0001635]; coreceptor activity [GO:0015026]	amylin receptor complex 1 [GO:0150056]; cell surface [GO:0009986]; CGRP receptor complex [GO:1990406]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; amylin receptor activity [GO:0097643]; calcitonin gene-related peptide binding [GO:1990407]; calcitonin gene-related peptide receptor activity [GO:0001635]; coreceptor activity [GO:0015026]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor signaling pathway [GO:0097647]; angiogenesis [GO:0001525]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion transport [GO:0006816]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular protein transport [GO:0006886]; positive regulation of protein glycosylation [GO:0060050]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
O60895	reviewed	RAMP2_HUMAN	Receptor activity-modifying protein 2 (Calcitonin-receptor-like receptor activity-modifying protein 2) (CRLR activity-modifying protein 2)	RAMP2	Homo sapiens (Human)	175	FUNCTION: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269|PubMed:22102369, ECO:0000269|PubMed:9620797}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adherens junction assembly [GO:0034333]; adrenomedullin receptor signaling pathway [GO:1990410]; amylin receptor signaling pathway [GO:0097647]; angiogenesis [GO:0001525]; basement membrane assembly [GO:0070831]; bicellular tight junction assembly [GO:0070830]; calcium ion transport [GO:0006816]; cellular response to hormone stimulus [GO:0032870]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of vascular permeability [GO:0043116]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; regulation of blood pressure [GO:0008217]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; sprouting angiogenesis [GO:0002040]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]	adrenomedullin receptor complex [GO:1903143]; amylin receptor complex 2 [GO:0150057]; cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	adrenomedullin binding [GO:1990409]; adrenomedullin receptor activity [GO:0001605]; coreceptor activity [GO:0015026]	adrenomedullin receptor complex [GO:1903143]; amylin receptor complex 2 [GO:0150057]; cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; adrenomedullin binding [GO:1990409]; adrenomedullin receptor activity [GO:0001605]; coreceptor activity [GO:0015026]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adherens junction assembly [GO:0034333]; adrenomedullin receptor signaling pathway [GO:1990410]; amylin receptor signaling pathway [GO:0097647]; angiogenesis [GO:0001525]; basement membrane assembly [GO:0070831]; bicellular tight junction assembly [GO:0070830]; calcium ion transport [GO:0006816]; cellular response to hormone stimulus [GO:0032870]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of vascular permeability [GO:0043116]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; regulation of blood pressure [GO:0008217]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; sprouting angiogenesis [GO:0002040]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
O60896	reviewed	RAMP3_HUMAN	Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)	RAMP3	Homo sapiens (Human)	148	FUNCTION: Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:9620797}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; amylin receptor signaling pathway [GO:0097647]; calcium ion transport [GO:0006816]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hormone stimulus [GO:0032870]; cross-receptor inhibition within G protein-coupled receptor heterodimer [GO:0038041]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway involved in heart process [GO:0086103]; intracellular protein transport [GO:0006886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of receptor recycling [GO:0001921]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; response to amyloid-beta [GO:1904645]	adrenomedullin receptor complex [GO:1903143]; amylin receptor complex 3 [GO:0150058]; cell surface [GO:0009986]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	adrenomedullin receptor activity [GO:0001605]; amyloid-beta binding [GO:0001540]; coreceptor activity [GO:0015026]	adrenomedullin receptor complex [GO:1903143]; amylin receptor complex 3 [GO:0150058]; cell surface [GO:0009986]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; adrenomedullin receptor activity [GO:0001605]; amyloid-beta binding [GO:0001540]; coreceptor activity [GO:0015026]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; amylin receptor signaling pathway [GO:0097647]; calcium ion transport [GO:0006816]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hormone stimulus [GO:0032870]; cross-receptor inhibition within G protein-coupled receptor heterodimer [GO:0038041]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway involved in heart process [GO:0086103]; intracellular protein transport [GO:0006886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of receptor recycling [GO:0001921]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; response to amyloid-beta [GO:1904645]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.
O60902	reviewed	SHOX2_HUMAN	Short stature homeobox protein 2 (Homeobox protein Og12X) (Paired-related homeobox protein SHOT)	SHOX2 OG12X SHOT	Homo sapiens (Human)	331	FUNCTION: May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.	cardiac pacemaker cell differentiation [GO:0060920]; cardiac right atrium morphogenesis [GO:0003213]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; chondrocyte development [GO:0002063]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic forelimb morphogenesis [GO:0035115]; embryonic skeletal joint morphogenesis [GO:0060272]; mesenchymal cell proliferation [GO:0010463]; muscle tissue morphogenesis [GO:0060415]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; osteoblast differentiation [GO:0001649]; positive regulation of axonogenesis [GO:0050772]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stem cell proliferation [GO:2000648]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of chondrocyte differentiation [GO:0032330]; regulation of heart rate [GO:0002027]; regulation of transcription by RNA polymerase II [GO:0006357]; sinoatrial node cell development [GO:0060931]; sinoatrial node development [GO:0003163]; sinoatrial valve development [GO:0003172]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; stem cell proliferation [GO:0072089]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; cardiac pacemaker cell differentiation [GO:0060920]; cardiac right atrium morphogenesis [GO:0003213]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; chondrocyte development [GO:0002063]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic forelimb morphogenesis [GO:0035115]; embryonic skeletal joint morphogenesis [GO:0060272]; mesenchymal cell proliferation [GO:0010463]; muscle tissue morphogenesis [GO:0060415]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; osteoblast differentiation [GO:0001649]; positive regulation of axonogenesis [GO:0050772]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stem cell proliferation [GO:2000648]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of chondrocyte differentiation [GO:0032330]; regulation of heart rate [GO:0002027]; regulation of transcription by RNA polymerase II [GO:0006357]; sinoatrial node cell development [GO:0060931]; sinoatrial node development [GO:0003163]; sinoatrial valve development [GO:0003172]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Nucleus.
O60906	reviewed	NSMA_HUMAN	Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase) (nSMase1)	SMPD2	Homo sapiens (Human)	423	FUNCTION: Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine (PubMed:10608884). Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo (PubMed:10608884). Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine (PubMed:10608884, PubMed:14741383). {ECO:0000269|PubMed:10608884, ECO:0000269|PubMed:14741383}.		ceramide biosynthetic process [GO:0046513]; sphingolipid catabolic process [GO:0030149]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684]	caveola [GO:0005901]; cell periphery [GO:0071944]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767]	caveola [GO:0005901]; cell periphery [GO:0071944]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767]; ceramide biosynthetic process [GO:0046513]; sphingolipid catabolic process [GO:0030149]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O70572}; Multi-pass membrane protein {ECO:0000255}.
O60907	reviewed	TBL1X_HUMAN	F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked)	TBL1X TBL1	Homo sapiens (Human)	577	FUNCTION: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). {ECO:0000269|PubMed:14980219, ECO:0000269|PubMed:21240272}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]	histone deacetylase complex [GO:0000118]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	histone binding [GO:0042393]; identical protein binding [GO:0042802]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]	histone deacetylase complex [GO:0000118]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalized with MECP2 to the heterochromatin foci. {ECO:0000250|UniProtKB:Q9QXE7}.
O60909	reviewed	B4GT2_HUMAN	Beta-1,4-galactosyltransferase 2 (Beta-1,4-GalTase 2) (Beta4Gal-T2) (b4Gal-T2) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2)	B4GALT2	Homo sapiens (Human)	372	FUNCTION: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids (PubMed:9405390). Can produce lactose (PubMed:9405390). {ECO:0000269|PubMed:9405390}.		carbohydrate metabolic process [GO:0005975]; cerebellar Purkinje cell layer development [GO:0021680]; glycosylation [GO:0070085]; locomotory behavior [GO:0007626]; memory [GO:0007613]; visual learning [GO:0008542]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; galactosyltransferase activity [GO:0008378]; lactose synthase activity [GO:0004461]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; galactosyltransferase activity [GO:0008378]; lactose synthase activity [GO:0004461]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]; carbohydrate metabolic process [GO:0005975]; cerebellar Purkinje cell layer development [GO:0021680]; glycosylation [GO:0070085]; locomotory behavior [GO:0007626]; memory [GO:0007613]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.
O60911	reviewed	CATL2_HUMAN	Cathepsin L2 (EC 3.4.22.43) (Cathepsin U) (Cathepsin V)	CTSV CATL2 CTSL2 CTSU UNQ268/PRO305	Homo sapiens (Human)	334	FUNCTION: Cysteine protease. May have an important role in corneal physiology. {ECO:0000269|PubMed:10029531, ECO:0000269|PubMed:9727401}.		antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; positive regulation of apoptotic signaling pathway [GO:2001235]; proteolysis involved in protein catabolic process [GO:0051603]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]	cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; serine-type endopeptidase activity [GO:0004252]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; positive regulation of apoptotic signaling pathway [GO:2001235]; proteolysis involved in protein catabolic process [GO:0051603]	SUBCELLULAR LOCATION: Lysosome {ECO:0000305}.
O60921	reviewed	HUS1_HUMAN	Checkpoint protein HUS1 (hHUS1)	HUS1	Homo sapiens (Human)	280	FUNCTION: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. {ECO:0000269|PubMed:21659603}.		cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; embryo development ending in birth or egg hatching [GO:0009792]; meiotic DNA integrity checkpoint signaling [GO:0044778]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; nucleotide-excision repair [GO:0006289]; regulation of protein phosphorylation [GO:0001932]; response to UV [GO:0009411]; telomere maintenance [GO:0000723]	checkpoint clamp complex [GO:0030896]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]		checkpoint clamp complex [GO:0030896]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; embryo development ending in birth or egg hatching [GO:0009792]; meiotic DNA integrity checkpoint signaling [GO:0044778]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; nucleotide-excision repair [GO:0006289]; regulation of protein phosphorylation [GO:0001932]; response to UV [GO:0009411]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10846170, ECO:0000269|PubMed:11077446}. Cytoplasm, cytosol {ECO:0000269|PubMed:11077446}. Note=In discrete nuclear foci upon DNA damage. According to PubMed:11077446, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:11077446}.
O60927	reviewed	PP1RB_HUMAN	E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3)	PPP1R11 HCGV TCTE5	Homo sapiens (Human)	126	FUNCTION: Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442). {ECO:0000269|PubMed:27805901, ECO:0000269|PubMed:9843442}.		defense response to Gram-positive bacterium [GO:0050830]; negative regulation of cytokine production [GO:0001818]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	phosphatase binding [GO:0019902]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; phosphatase binding [GO:0019902]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ubiquitin protein ligase activity [GO:0061630]; defense response to Gram-positive bacterium [GO:0050830]; negative regulation of cytokine production [GO:0001818]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	
O60928	reviewed	KCJ13_HUMAN	Inward rectifier potassium channel 13 (Inward rectifier K(+) channel Kir7.1) (Potassium channel, inwardly rectifying subfamily J member 13)	KCNJ13	Homo sapiens (Human)	360	FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.		potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]	plasma membrane [GO:0005886]	inward rectifier potassium channel activity [GO:0005242]	plasma membrane [GO:0005886]; inward rectifier potassium channel activity [GO:0005242]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
O60930	reviewed	RNH1_HUMAN	Ribonuclease H1 (RNase H1) (EC 3.1.26.4) (Ribonuclease H type II)	RNASEH1 RNH1	Homo sapiens (Human)	286	FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224). {ECO:0000269|PubMed:10497183, ECO:0000269|PubMed:21700224}.		DNA replication, removal of RNA primer [GO:0043137]; RNA catabolic process [GO:0006401]	cytoplasm [GO:0005737]	magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; RNA-DNA hybrid ribonuclease activity [GO:0004523]	cytoplasm [GO:0005737]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; DNA replication, removal of RNA primer [GO:0043137]; RNA catabolic process [GO:0006401]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
O60931	reviewed	CTNS_HUMAN	Cystinosin	CTNS	Homo sapiens (Human)	367	FUNCTION: Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (PubMed:11689434, PubMed:18337546, PubMed:22232659, PubMed:29467429, PubMed:33208952, PubMed:15128704). Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis (PubMed:22649030). In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes (By similarity). Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity (By similarity). {ECO:0000250|UniProtKB:P57757, ECO:0000269|PubMed:11689434, ECO:0000269|PubMed:15128704, ECO:0000269|PubMed:18337546, ECO:0000269|PubMed:22232659, ECO:0000269|PubMed:22649030, ECO:0000269|PubMed:29467429, ECO:0000269|PubMed:33208952}.		adult walking behavior [GO:0007628]; amino acid metabolic process [GO:0006520]; ATP metabolic process [GO:0046034]; brain development [GO:0007420]; brush border assembly [GO:1904970]; cognition [GO:0050890]; glutathione metabolic process [GO:0006749]; grooming behavior [GO:0007625]; L-cystine transport [GO:0015811]; lens development in camera-type eye [GO:0002088]; long-term memory [GO:0007616]; melanin biosynthetic process [GO:0042438]; monoatomic ion transport [GO:0006811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of TORC1 signaling [GO:1904263]; protein transport [GO:0015031]; proximal tubule morphogenesis [GO:0072158]; regulation of melanin biosynthetic process [GO:0048021]; renal albumin absorption [GO:0097018]; renal glucose absorption [GO:0035623]; renal phosphate ion absorption [GO:0097291]; renal water absorption [GO:0070295]; thyroid gland development [GO:0030878]; transmembrane transport [GO:0055085]; visual learning [GO:0008542]	extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; plasma membrane [GO:0005886]	L-cystine transmembrane transporter activity [GO:0015184]; solute:proton symporter activity [GO:0015295]	extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; plasma membrane [GO:0005886]; L-cystine transmembrane transporter activity [GO:0015184]; solute:proton symporter activity [GO:0015295]; adult walking behavior [GO:0007628]; amino acid metabolic process [GO:0006520]; ATP metabolic process [GO:0046034]; brain development [GO:0007420]; brush border assembly [GO:1904970]; cognition [GO:0050890]; glutathione metabolic process [GO:0006749]; grooming behavior [GO:0007625]; L-cystine transport [GO:0015811]; lens development in camera-type eye [GO:0002088]; long-term memory [GO:0007616]; melanin biosynthetic process [GO:0042438]; monoatomic ion transport [GO:0006811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of TORC1 signaling [GO:1904263]; protein transport [GO:0015031]; proximal tubule morphogenesis [GO:0072158]; regulation of melanin biosynthetic process [GO:0048021]; renal albumin absorption [GO:0097018]; renal glucose absorption [GO:0035623]; renal phosphate ion absorption [GO:0097291]; renal water absorption [GO:0070295]; thyroid gland development [GO:0030878]; transmembrane transport [GO:0055085]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: [Isoform 1]: Lysosome membrane {ECO:0000269|PubMed:11150305, ECO:0000269|PubMed:11689434, ECO:0000269|PubMed:15128704, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:25753619, ECO:0000269|PubMed:28082515}; Multi-pass membrane protein {ECO:0000255}. Melanosome membrane {ECO:0000269|PubMed:22649030}; Multi-pass membrane protein {ECO:0000255}. Note=AP-3 complex is required for localization to the lysosome. {ECO:0000269|PubMed:25753619}.; SUBCELLULAR LOCATION: [Isoform 2]: Lysosome membrane {ECO:0000269|PubMed:18337546, ECO:0000269|PubMed:27148969}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:18337546, ECO:0000269|PubMed:27148969}; Multi-pass membrane protein {ECO:0000255}.
O60934	reviewed	NBN_HUMAN	Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1)	NBN NBS NBS1 P95	Homo sapiens (Human)	754	FUNCTION: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex. {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:9705271}.	MISCELLANEOUS: In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells.	blastocyst growth [GO:0001832]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; homologous recombination [GO:0035825]; intrinsic apoptotic signaling pathway [GO:0097193]; isotype switching [GO:0045190]; meiotic cell cycle [GO:0051321]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of telomere capping [GO:1904354]; neuroblast proliferation [GO:0007405]; neuromuscular process controlling balance [GO:0050885]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated DNA replication initiation [GO:0030174]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via telomere trimming [GO:0090737]; telomeric 3' overhang formation [GO:0031860]	BRCA1-C complex [GO:0070533]; chromosomal region [GO:0098687]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Mre11 complex [GO:0030870]; nuclear inclusion body [GO:0042405]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]	damaged DNA binding [GO:0003684]; DNA-binding transcription factor binding [GO:0140297]	BRCA1-C complex [GO:0070533]; chromosomal region [GO:0098687]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Mre11 complex [GO:0030870]; nuclear inclusion body [GO:0042405]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]; damaged DNA binding [GO:0003684]; DNA-binding transcription factor binding [GO:0140297]; blastocyst growth [GO:0001832]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; homologous recombination [GO:0035825]; intrinsic apoptotic signaling pathway [GO:0097193]; isotype switching [GO:0045190]; meiotic cell cycle [GO:0051321]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of telomere capping [GO:1904354]; neuroblast proliferation [GO:0007405]; neuromuscular process controlling balance [GO:0050885]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated DNA replication initiation [GO:0030174]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via telomere trimming [GO:0090737]; telomeric 3' overhang formation [GO:0031860]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10783165, ECO:0000269|PubMed:26215093}. Nucleus, PML body {ECO:0000269|PubMed:12470659, ECO:0000269|PubMed:15916964}. Chromosome, telomere {ECO:0000269|PubMed:10888888}. Chromosome {ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26438602}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents (PubMed:26438602, PubMed:10783165, PubMed:26215093). Acetylation of 'Lys-5' of histone H2AX (H2AXK5ac) promotes NBN/NBS1 assembly at the sites of DNA damage (PubMed:26438602). {ECO:0000269|PubMed:10783165, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26438602}.
O60936	reviewed	NOL3_HUMAN	Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30)	NOL3 ARC NOP	Homo sapiens (Human)	208	FUNCTION: [Isoform 1]: May be involved in RNA splicing. {ECO:0000269|PubMed:10196175}.; FUNCTION: [Isoform 2]: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity). {ECO:0000250|UniProtKB:Q62881, ECO:0000250|UniProtKB:Q9D1X0, ECO:0000269|PubMed:15004034, ECO:0000269|PubMed:15509781}.		apoptotic process [GO:0006915]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mRNA splice site recognition [GO:0006376]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; protein complex oligomerization [GO:0051259]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; sarcoplasmic reticulum [GO:0016529]	calcium ion binding [GO:0005509]; caspase binding [GO:0089720]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; sarcoplasmic reticulum [GO:0016529]; calcium ion binding [GO:0005509]; caspase binding [GO:0089720]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mRNA splice site recognition [GO:0006376]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; protein complex oligomerization [GO:0051259]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleolus {ECO:0000269|PubMed:10196175}. Note=The SR-rich C-terminus mediates nuclear localization. {ECO:0000269|PubMed:10196175}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:10196175}. Mitochondrion {ECO:0000250|UniProtKB:Q62881}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q62881}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Phosphorylation at Thr-149 results in translocation to mitochondria. Colocalized with mitochondria in response to oxidative stress. {ECO:0000250|UniProtKB:Q62881}.
O60938	reviewed	KERA_HUMAN	Keratocan (KTN) (Keratan sulfate proteoglycan keratocan)	KERA SLRR2B	Homo sapiens (Human)	352	FUNCTION: May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. {ECO:0000305|PubMed:10802664, ECO:0000305|PubMed:11726611}.		cornea development in camera-type eye [GO:0061303]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]		extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; cornea development in camera-type eye [GO:0061303]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
O60939	reviewed	SCN2B_HUMAN	Sodium channel subunit beta-2	SCN2B UNQ326/PRO386	Homo sapiens (Human)	215	FUNCTION: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). {ECO:0000250}.		cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; chemical synaptic transmission [GO:0007268]; gene expression [GO:0010467]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; nervous system development [GO:0007399]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; response to heat [GO:0009408]; response to pyrethroid [GO:0046684]; sodium ion transmembrane transport [GO:0035725]	plasma membrane [GO:0005886]; synapse [GO:0045202]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518]	sodium channel regulator activity [GO:0017080]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]	plasma membrane [GO:0005886]; synapse [GO:0045202]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518]; sodium channel regulator activity [GO:0017080]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; chemical synaptic transmission [GO:0007268]; gene expression [GO:0010467]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; nervous system development [GO:0007399]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; response to heat [GO:0009408]; response to pyrethroid [GO:0046684]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
O60941	reviewed	DTNB_HUMAN	Dystrobrevin beta (DTN-B) (Beta-dystrobrevin)	DTNB	Homo sapiens (Human)	627	FUNCTION: Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	neuron differentiation [GO:0030182]; synaptic signaling [GO:0099536]	basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; inhibitory synapse [GO:0060077]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	zinc ion binding [GO:0008270]	basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; inhibitory synapse [GO:0060077]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202]; zinc ion binding [GO:0008270]; neuron differentiation [GO:0030182]; synaptic signaling [GO:0099536]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27223470}. Postsynaptic density {ECO:0000250|UniProtKB:P84060}. Cell projection, dendrite {ECO:0000250|UniProtKB:O70585}. Basal cell membrane {ECO:0000250|UniProtKB:O70585}. Postsynapse {ECO:0000250|UniProtKB:O70585}. Nucleus {ECO:0000269|PubMed:27223470}. Note=Localized at inhibitory synapses on the dendrites of cerebellar Purkinje cells. {ECO:0000250|UniProtKB:O70585}.
O60942	reviewed	MCE1_HUMAN	mRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)]	RNGTT CAP1A	Homo sapiens (Human)	597	FUNCTION: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate. {ECO:0000269|PubMed:21636784, ECO:0000269|PubMed:9473487, ECO:0000269|PubMed:9512541}.	MISCELLANEOUS: Isoform 2 to isoform 4 lack mRNA 5'-guanylyltransferase activity due to disruptions of the GTase domain.	7-methylguanosine mRNA capping [GO:0006370]; dephosphorylation [GO:0016311]; RNA processing [GO:0006396]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; inorganic triphosphate phosphatase activity [GO:0050355]; mRNA 5'-phosphatase activity [GO:0140818]; mRNA guanylyltransferase activity [GO:0004484]; polynucleotide 5'-phosphatase activity [GO:0004651]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA guanylyltransferase activity [GO:0008192]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; inorganic triphosphate phosphatase activity [GO:0050355]; mRNA 5'-phosphatase activity [GO:0140818]; mRNA guanylyltransferase activity [GO:0004484]; polynucleotide 5'-phosphatase activity [GO:0004651]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA guanylyltransferase activity [GO:0008192]; 7-methylguanosine mRNA capping [GO:0006370]; dephosphorylation [GO:0016311]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
O75015	reviewed	FCG3B_HUMAN	Low affinity immunoglobulin gamma Fc region receptor III-B (Fc-gamma RIII-beta) (CD16-I) (Fc-gamma RIII) (Fc-gamma RIIIb) (FcRIII) (FcRIIIb) (FcR-10) (IgG Fc receptor III-1) (CD antigen CD16b)	FCGR3B CD16B FCG3 FCGR3 IGFR3	Homo sapiens (Human)	233	FUNCTION: Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.	MISCELLANEOUS: Encoded by one of two nearly identical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue-specific manner. The 'Phe-203' in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring.	cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; regulation of immune response [GO:0050776]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; side of membrane [GO:0098552]	GPI anchor binding [GO:0034235]; IgG binding [GO:0019864]; transmembrane signaling receptor activity [GO:0004888]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; side of membrane [GO:0098552]; GPI anchor binding [GO:0034235]; IgG binding [GO:0019864]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1825220}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1825220}. Secreted. Note=Secreted after cleavage.
O75019	reviewed	LIRA1_HUMAN	Leukocyte immunoglobulin-like receptor subfamily A member 1 (CD85 antigen-like family member I) (Leukocyte immunoglobulin-like receptor 6) (LIR-6) (CD antigen CD85i)	LILRA1 LIR6	Homo sapiens (Human)	489	FUNCTION: May act as receptor for class I MHC antigens.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]	plasma membrane [GO:0005886]	antigen binding [GO:0003823]; inhibitory MHC class I receptor activity [GO:0032396]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; antigen binding [GO:0003823]; inhibitory MHC class I receptor activity [GO:0032396]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
O75022	reviewed	LIRB3_HUMAN	Leukocyte immunoglobulin-like receptor subfamily B member 3 (LIR-3) (Leukocyte immunoglobulin-like receptor 3) (CD85 antigen-like family member A) (Immunoglobulin-like transcript 5) (ILT-5) (Monocyte inhibitory receptor HL9) (CD antigen CD85a)	LILRB3 ILT5 LIR3	Homo sapiens (Human)	631	FUNCTION: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). {ECO:0000250|UniProtKB:P97484}.	MISCELLANEOUS: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.	adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; defense response [GO:0006952]; negative regulation of osteoclast differentiation [GO:0045671]	plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; defense response [GO:0006952]; negative regulation of osteoclast differentiation [GO:0045671]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
O75023	reviewed	LIRB5_HUMAN	Leukocyte immunoglobulin-like receptor subfamily B member 5 (CD85 antigen-like family member C) (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD antigen CD85c)	LILRB5 LIR8	Homo sapiens (Human)	590	FUNCTION: May act as receptor for class I MHC antigens.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; defense response [GO:0006952]	plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; defense response [GO:0006952]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
O75027	reviewed	ABCB7_HUMAN	Iron-sulfur clusters transporter ABCB7, mitochondrial (ATP-binding cassette sub-family B member 7, mitochondrial) (ATP-binding cassette transporter 7) (ABC transporter 7 protein)	ABCB7 ABC7	Homo sapiens (Human)	752	FUNCTION: Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (PubMed:33157103, PubMed:17192393, PubMed:10196363). Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q61102, ECO:0000250|UniProtKB:Q704E8, ECO:0000269|PubMed:10196363, ECO:0000269|PubMed:17192393, ECO:0000269|PubMed:30765471, ECO:0000269|PubMed:33157103}.		intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; iron-sulfur cluster assembly [GO:0016226]; iron-sulfur cluster export from the mitochondrion [GO:0140466]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of iron-sulfur cluster assembly [GO:1903331]; transmembrane transport [GO:0055085]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	ABC-type iron-sulfur cluster transporter activity [GO:0140481]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; heme transmembrane transporter activity [GO:0015232]; protein homodimerization activity [GO:0042803]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ABC-type iron-sulfur cluster transporter activity [GO:0140481]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; heme transmembrane transporter activity [GO:0015232]; protein homodimerization activity [GO:0042803]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; iron-sulfur cluster assembly [GO:0016226]; iron-sulfur cluster export from the mitochondrion [GO:0140466]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of iron-sulfur cluster assembly [GO:1903331]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P40416}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P40416}.
O75030	reviewed	MITF_HUMAN	Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32)	MITF BHLHE32	Homo sapiens (Human)	526	FUNCTION: Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (PubMed:36608670). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). {ECO:0000269|PubMed:10587587, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:27889061, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:9647758}.		bone remodeling [GO:0046849]; camera-type eye development [GO:0043010]; cell fate commitment [GO:0045165]; melanocyte apoptotic process [GO:1902362]; melanocyte differentiation [GO:0030318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoclast differentiation [GO:0030316]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of osteoclast differentiation [GO:0045670]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; bone remodeling [GO:0046849]; camera-type eye development [GO:0043010]; cell fate commitment [GO:0045165]; melanocyte apoptotic process [GO:1902362]; melanocyte differentiation [GO:0030318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoclast differentiation [GO:0030316]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of osteoclast differentiation [GO:0045670]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:27889061, ECO:0000269|PubMed:28842328, ECO:0000269|PubMed:36608670}. Cytoplasm {ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:28842328, ECO:0000269|PubMed:36608670}. Lysosome membrane {ECO:0000269|PubMed:23401004, ECO:0000269|PubMed:36608670}. Note=When nutrients are present, recruited to the lysosomal membrane via association with GDP-bound RagC/RRAGC (or RagD/RRAGD): it is then phosphorylated by MTOR (PubMed:23401004, PubMed:36608670). Phosphorylation by MTOR promotes ubiquitination and degradation (PubMed:36608670). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:36608670). Phosphorylation by MARK3/cTAK1 promotes association with 14-3-3/YWHA adapters and retention in the cytosol (PubMed:16822840). {ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:23401004, ECO:0000269|PubMed:36608670}.
O75031	reviewed	HSF2B_HUMAN	Heat shock factor 2-binding protein	HSF2BP MEILB2	Homo sapiens (Human)	334	FUNCTION: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) (PubMed:31242413). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity). Required for proper recombinase recruitment in female meiosis (By similarity). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). May be involved in modulating HSF2 activation in testis (PubMed:9651507). {ECO:0000250|UniProtKB:Q9D4G2, ECO:0000269|PubMed:31242413, ECO:0000269|PubMed:9651507}.		double-strand break repair involved in meiotic recombination [GO:1990918]; female meiosis I [GO:0007144]; male meiosis I [GO:0007141]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]		chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; double-strand break repair involved in meiotic recombination [GO:1990918]; female meiosis I [GO:0007144]; male meiosis I [GO:0007141]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D4G2}. Chromosome {ECO:0000269|PubMed:31242413}. Note=Localizes on double-strand breaks (DSBs) in mitotic and meiotic chromosomes. {ECO:0000269|PubMed:31242413}.
O75037	reviewed	KI21B_HUMAN	Kinesin-like protein KIF21B	KIF21B KIAA0449	Homo sapiens (Human)	1637	FUNCTION: Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}.		microtubule-based movement [GO:0007018]	cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; growth cone [GO:0030426]; kinesin complex [GO:0005871]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; growth cone [GO:0030426]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QXL1}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QXL1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9QXL1}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QXL1}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:F1M5N7}.
O75038	reviewed	PLCH2_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-2) (Phosphoinositide phospholipase C-like 4) (PLC-L4) (Phospholipase C-like protein 4) (Phospholipase C-eta-2) (PLC-eta2)	PLCH2 KIAA0450 PLCL4	Homo sapiens (Human)	1416	FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:18361507). This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity). {ECO:0000250|UniProtKB:A2AP18, ECO:0000269|PubMed:18361507}.		lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; release of sequestered calcium ion into cytosol [GO:0051209]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; release of sequestered calcium ion into cytosol [GO:0051209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2AP18}. Cell membrane {ECO:0000250|UniProtKB:A2AP18}. Note=Localized predominantly at the plasma membrane. {ECO:0000250|UniProtKB:A2AP18}.
O75044	reviewed	SRGP2_HUMAN	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34)	SRGAP2 ARHGAP34 FNBP2 KIAA0456 SRGAP2A	Homo sapiens (Human)	1071	FUNCTION: Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}.	MISCELLANEOUS: There are 3 duplications of SRGAP2 in the human genome as a result of segmental gene duplications. SRGAP2C is the only one to be fixed at a diploid state in the human genome. Moreover, SRGAP2C is functional, interacts with and inhibits SRGAP2 and is human-specific. The appearance of SRGAP2C in the human genome is estimated to 2,4 million years ago, which corresponds to the beginning of neocortex expansion in human evolution and it may have played an important role in this process through its interaction with SRGAP2 function.	actin filament severing [GO:0051014]; dendritic spine development [GO:0060996]; excitatory synapse assembly [GO:1904861]; extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [GO:0021816]; filopodium assembly [GO:0046847]; inhibitory synapse assembly [GO:1904862]; lamellipodium assembly involved in ameboidal cell migration [GO:0003363]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron migration [GO:2001223]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine head [GO:0044327]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]	GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine head [GO:0044327]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; actin filament severing [GO:0051014]; dendritic spine development [GO:0060996]; excitatory synapse assembly [GO:1904861]; extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [GO:0021816]; filopodium assembly [GO:0046847]; inhibitory synapse assembly [GO:1904862]; lamellipodium assembly involved in ameboidal cell migration [GO:0003363]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron migration [GO:2001223]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21148482}. Cell projection, dendritic spine {ECO:0000303|PubMed:22559944}. Postsynaptic density {ECO:0000250|UniProtKB:Q91Z67}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q91Z67}. Cell projection, lamellipodium {ECO:0000269|PubMed:20810653}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q91Z67}. Nucleus {ECO:0000250|UniProtKB:D4A208}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91Z67}. Note=Recruited to actin-rich phagosomes during phagocytosis (By similarity). Translocates from nucleus to cytoplasm during development (By similarity). {ECO:0000250|UniProtKB:D4A208, ECO:0000250|UniProtKB:Q91Z67}.
O75051	reviewed	PLXA2_HUMAN	Plexin-A2 (Semaphorin receptor OCT)	PLXNA2 KIAA0463 OCT PLXN2 UNQ209/PRO235	Homo sapiens (Human)	1894	FUNCTION: Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:10520995}.		centrosome localization [GO:0051642]; cerebellar granule cell precursor tangential migration [GO:0021935]; limb bud formation [GO:0060174]; negative regulation of cell adhesion [GO:0007162]; neural tube development [GO:0021915]; pharyngeal system development [GO:0060037]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; somitogenesis [GO:0001756]	plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	identical protein binding [GO:0042802]; semaphorin receptor activity [GO:0017154]	plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]; identical protein binding [GO:0042802]; semaphorin receptor activity [GO:0017154]; centrosome localization [GO:0051642]; cerebellar granule cell precursor tangential migration [GO:0021935]; limb bud formation [GO:0060174]; negative regulation of cell adhesion [GO:0007162]; neural tube development [GO:0021915]; pharyngeal system development [GO:0060037]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
O75052	reviewed	CAPON_HUMAN	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein)	NOS1AP CAPON KIAA0464	Homo sapiens (Human)	506	FUNCTION: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). {ECO:0000250|UniProtKB:O54960, ECO:0000269|PubMed:33523862}.		positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of heart rate by chemical signal [GO:0003062]; regulation of high voltage-gated calcium channel activity [GO:1901841]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]	anchoring junction [GO:0070161]; caveola [GO:0005901]; cytosol [GO:0005829]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; podosome [GO:0002102]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017]; T-tubule [GO:0030315]; Z disc [GO:0030018]	nitric-oxide synthase binding [GO:0050998]	anchoring junction [GO:0070161]; caveola [GO:0005901]; cytosol [GO:0005829]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; podosome [GO:0002102]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017]; T-tubule [GO:0030315]; Z disc [GO:0030018]; nitric-oxide synthase binding [GO:0050998]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of heart rate by chemical signal [GO:0003062]; regulation of high voltage-gated calcium channel activity [GO:1901841]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]	SUBCELLULAR LOCATION: Cell projection, filopodium {ECO:0000250|UniProtKB:O54960}. Cell projection, podosome {ECO:0000250|UniProtKB:O54960}.
O75054	reviewed	IGSF3_HUMAN	Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3)	IGSF3 EWI3 KIAA0466	Homo sapiens (Human)	1194		MISCELLANEOUS: Likely interchromosomal Alu-mediated fusion between IGSF3 on 1p13.1 and GGT on 22q11.2. Breakpoints occurred inside Alu elements as well as in the 5' or 3' ends of them.	lacrimal gland development [GO:0032808]	cell surface [GO:0009986]; membrane [GO:0016020]		cell surface [GO:0009986]; membrane [GO:0016020]; lacrimal gland development [GO:0032808]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O75056	reviewed	SDC3_HUMAN	Syndecan-3 (SYND3)	SDC3 KIAA0468	Homo sapiens (Human)	442	FUNCTION: Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. {ECO:0000250, ECO:0000269|PubMed:11527150}.		cell migration [GO:0016477]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; microspike [GO:0044393]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; microspike [GO:0044393]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; cell migration [GO:0016477]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
O75061	reviewed	AUXI_HUMAN	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6)	DNAJC6 KIAA0473	Homo sapiens (Human)	913	FUNCTION: Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity). {ECO:0000250|UniProtKB:Q80TZ3}.		clathrin-dependent endocytosis [GO:0072583]; dephosphorylation [GO:0016311]; regulation of clathrin-dependent endocytosis [GO:2000369]; synaptic vesicle uncoating [GO:0016191]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; intracellular membrane-bounded organelle [GO:0043231]; postsynaptic density [GO:0014069]; vesicle [GO:0031982]	clathrin binding [GO:0030276]; protein tyrosine phosphatase activity [GO:0004725]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; intracellular membrane-bounded organelle [GO:0043231]; postsynaptic density [GO:0014069]; vesicle [GO:0031982]; clathrin binding [GO:0030276]; protein tyrosine phosphatase activity [GO:0004725]; SH3 domain binding [GO:0017124]; clathrin-dependent endocytosis [GO:0072583]; dephosphorylation [GO:0016311]; regulation of clathrin-dependent endocytosis [GO:2000369]; synaptic vesicle uncoating [GO:0016191]	
O75063	reviewed	XYLK_HUMAN	Glycosaminoglycan xylosylkinase (EC 2.7.1.-) (Xylose kinase)	FAM20B KIAA0475	Homo sapiens (Human)	409	FUNCTION: Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized. {ECO:0000269|PubMed:19473117, ECO:0000269|PubMed:24425863}.		phosphorylation [GO:0016310]; proteoglycan biosynthetic process [GO:0030166]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; phosphorylation [GO:0016310]; proteoglycan biosynthetic process [GO:0030166]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19473117}; Single-pass type II membrane protein {ECO:0000269|PubMed:19473117}.
O75069	reviewed	TMCC2_HUMAN	Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11)	TMCC2 KIAA0481 hucep-11	Homo sapiens (Human)	709	FUNCTION: May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}.		amyloid precursor protein metabolic process [GO:0042982]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]		endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; amyloid precursor protein metabolic process [GO:0042982]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21593558, ECO:0000269|PubMed:24454821, ECO:0000269|PubMed:30220460}; Multi-pass membrane protein {ECO:0000255}. Note=Concentrates in discrete patches along peripheral endoplasmic reticulum tubules. {ECO:0000269|PubMed:30220460}.
O75072	reviewed	FKTN_HUMAN	Ribitol-5-phosphate transferase FKTN (EC 2.7.8.-) (Fukutin) (Fukuyama-type congenital muscular dystrophy protein) (Ribitol-5-phosphate transferase)	FKTN FCMD	Homo sapiens (Human)	461	FUNCTION: Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:26923585, PubMed:29477842, PubMed:27194101). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:29477842, PubMed:27194101). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity (PubMed:17034757). May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes (PubMed:25279699). Could be involved in brain development (Probable). {ECO:0000269|PubMed:17034757, ECO:0000269|PubMed:25279699, ECO:0000269|PubMed:26923585, ECO:0000269|PubMed:27194101, ECO:0000269|PubMed:29477842, ECO:0000305|PubMed:11115853}.		muscle organ development [GO:0007517]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of JNK cascade [GO:0046329]; nervous system development [GO:0007399]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]; regulation of protein glycosylation [GO:0060049]	cis-Golgi network [GO:0005801]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]	phosphotransferase activity, for other substituted phosphate groups [GO:0016780]	cis-Golgi network [GO:0005801]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; muscle organ development [GO:0007517]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of JNK cascade [GO:0046329]; nervous system development [GO:0007399]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]; regulation of protein glycosylation [GO:0060049]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:25279699, ECO:0000269|PubMed:29477842, ECO:0000305|PubMed:26923585}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:Q8R507}. Nucleus {ECO:0000250|UniProtKB:Q8R507}. Note=In retinal tissue, does not localize with the Golgi apparatus. {ECO:0000250|UniProtKB:Q8R507}.
O75074	reviewed	LRP3_HUMAN	Low-density lipoprotein receptor-related protein 3 (LRP-3) (105 kDa low-density lipoprotein receptor-related protein) (hLRp105)	LRP3	Homo sapiens (Human)	770	FUNCTION: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.		negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; receptor-mediated endocytosis [GO:0006898]; transport across blood-brain barrier [GO:0150104]	clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886]		clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; receptor-mediated endocytosis [GO:0006898]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Membrane, coated pit {ECO:0000250}.
O75077	reviewed	ADA23_HUMAN	Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3)	ADAM23 MDC3	Homo sapiens (Human)	832	FUNCTION: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.		cell adhesion [GO:0007155]; cellular response to leukemia inhibitory factor [GO:1990830]; central nervous system development [GO:0007417]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; cell adhesion [GO:0007155]; cellular response to leukemia inhibitory factor [GO:1990830]; central nervous system development [GO:0007417]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform Gamma]: Secreted.
O75078	reviewed	ADA11_HUMAN	Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC)	ADAM11 MDC	Homo sapiens (Human)	769	FUNCTION: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress (By similarity). Plays a role in spatial learning and motor coordination (By similarity). Involved in the nociceptive pain response to chemical-derived stimulation (By similarity). {ECO:0000250|UniProtKB:Q9R1V4}.	MISCELLANEOUS: [Isoform Short]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	behavioral response to acetic acid induced pain [GO:0061367]; behavioral response to formalin induced pain [GO:0061368]; establishment of protein localization [GO:0045184]; integrin-mediated signaling pathway [GO:0007229]; multicellular organismal response to stress [GO:0033555]; proteolysis [GO:0006508]	axon [GO:0030424]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	axon [GO:0030424]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; behavioral response to acetic acid induced pain [GO:0061367]; behavioral response to formalin induced pain [GO:0061368]; establishment of protein localization [GO:0045184]; integrin-mediated signaling pathway [GO:0007229]; multicellular organismal response to stress [GO:0033555]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9R1V4}; Single-pass type I membrane protein. Perikaryon {ECO:0000250|UniProtKB:Q9R1V4}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1V4}. Note=Localizes to basket cell terminals and pinceaux. {ECO:0000250|UniProtKB:Q9R1V4}.
O75081	reviewed	MTG16_HUMAN	Protein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4)	CBFA2T3 MTG16 MTGR2 ZMYND4	Homo sapiens (Human)	653	FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665). {ECO:0000250|UniProtKB:O54972, ECO:0000269|PubMed:12183414, ECO:0000269|PubMed:15231665, ECO:0000269|PubMed:16966434, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23840896, ECO:0000269|PubMed:25974097, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.; FUNCTION: Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486). {ECO:0000269|PubMed:11823486}.		DNA-templated transcription [GO:0006351]; granulocyte differentiation [GO:0030851]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glycolytic process [GO:0045820]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of aerobic respiration [GO:1903715]; response to hypoxia [GO:0001666]	Golgi membrane [GO:0000139]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	Golgi membrane [GO:0000139]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; DNA-templated transcription [GO:0006351]; granulocyte differentiation [GO:0030851]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glycolytic process [GO:0045820]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of aerobic respiration [GO:1903715]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleolus. Note=The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, nucleoplasm {ECO:0000269|PubMed:11823486}. Golgi apparatus membrane {ECO:0000269|PubMed:11823486}.
O75083	reviewed	WDR1_HUMAN	WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)	WDR1	Homo sapiens (Human)	606	FUNCTION: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). {ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2, ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608, ECO:0000269|PubMed:25792565, ECO:0000269|PubMed:27557945, ECO:0000269|PubMed:29751004}.		actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; apical junction assembly [GO:0043297]; cortical cytoskeleton organization [GO:0030865]; establishment of planar polarity of follicular epithelium [GO:0042247]; locomotion [GO:0040011]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; platelet formation [GO:0030220]; positive regulation of actin filament depolymerization [GO:0030836]; regulation of actin filament depolymerization [GO:0030834]; regulation of cell shape [GO:0008360]; regulation of oligodendrocyte differentiation [GO:0048713]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sarcomere organization [GO:0045214]; sensory perception of sound [GO:0007605]	cell junction [GO:0030054]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; podosome [GO:0002102]	actin filament binding [GO:0051015]	cell junction [GO:0030054]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; podosome [GO:0002102]; actin filament binding [GO:0051015]; actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; apical junction assembly [GO:0043297]; cortical cytoskeleton organization [GO:0030865]; establishment of planar polarity of follicular epithelium [GO:0042247]; locomotion [GO:0040011]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; platelet formation [GO:0030220]; positive regulation of actin filament depolymerization [GO:0030836]; regulation of actin filament depolymerization [GO:0030834]; regulation of cell shape [GO:0008360]; regulation of oligodendrocyte differentiation [GO:0048713]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sarcomere organization [GO:0045214]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27994071}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5RKI0}. Cell projection, podosome {ECO:0000269|PubMed:22721921}. Cell junction {ECO:0000269|PubMed:25792565}.
O75084	reviewed	FZD7_HUMAN	Frizzled-7 (Fz-7) (hFz7) (FzE3)	FZD7	Homo sapiens (Human)	574	FUNCTION: Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed:26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. {ECO:0000250|UniProtKB:Q61090, ECO:0000269|PubMed:26126266}.; FUNCTION: (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. {ECO:0000269|PubMed:27680706}.		canonical Wnt signaling pathway [GO:0060070]; cellular response to retinoic acid [GO:0071300]; mesenchymal to epithelial transition [GO:0060231]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of ectodermal cell fate specification [GO:0042666]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; non-canonical Wnt signaling pathway via JNK cascade [GO:0038031]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphorylation [GO:0042327]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA-templated transcription [GO:0006355]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; somatic stem cell division [GO:0048103]; stem cell population maintenance [GO:0019827]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell differentiation in thymus [GO:0033077]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	frizzled binding [GO:0005109]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; frizzled binding [GO:0005109]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; canonical Wnt signaling pathway [GO:0060070]; cellular response to retinoic acid [GO:0071300]; mesenchymal to epithelial transition [GO:0060231]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of ectodermal cell fate specification [GO:0042666]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; non-canonical Wnt signaling pathway via JNK cascade [GO:0038031]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphorylation [GO:0042327]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA-templated transcription [GO:0006355]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; somatic stem cell division [GO:0048103]; stem cell population maintenance [GO:0019827]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell differentiation in thymus [GO:0033077]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27386966}; Multi-pass membrane protein {ECO:0000269|PubMed:27386966}. Endosome membrane {ECO:0000269|PubMed:27386966}; Multi-pass membrane protein {ECO:0000269|PubMed:27386966}. Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. {ECO:0000269|PubMed:27386966}.
O75093	reviewed	SLIT1_HUMAN	Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4)	SLIT1 KIAA0813 MEGF4 SLIL1	Homo sapiens (Human)	1534	FUNCTION: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. {ECO:0000250}.		axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; dorsal/ventral axon guidance [GO:0033563]; forebrain morphogenesis [GO:0048853]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of synapse assembly [GO:0051964]; nuclear migration [GO:0007097]; retinal ganglion cell axon guidance [GO:0031290]; spinal cord development [GO:0021510]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]	extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495]	extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; dorsal/ventral axon guidance [GO:0033563]; forebrain morphogenesis [GO:0048853]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of synapse assembly [GO:0051964]; nuclear migration [GO:0007097]; retinal ganglion cell axon guidance [GO:0031290]; spinal cord development [GO:0021510]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
O75094	reviewed	SLIT3_HUMAN	Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5)	SLIT3 KIAA0814 MEGF5 SLIL2 UNQ691/PRO1336	Homo sapiens (Human)	1523	FUNCTION: May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.		aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; atrioventricular valve morphogenesis [GO:0003181]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cellular response to hormone stimulus [GO:0032870]; negative chemotaxis [GO:0050919]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; response to cortisol [GO:0051414]; Roundabout signaling pathway [GO:0035385]; ventricular septum morphogenesis [GO:0060412]	extracellular space [GO:0005615]; mitochondrion [GO:0005739]	calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495]	extracellular space [GO:0005615]; mitochondrion [GO:0005739]; calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; atrioventricular valve morphogenesis [GO:0003181]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cellular response to hormone stimulus [GO:0032870]; negative chemotaxis [GO:0050919]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; response to cortisol [GO:0051414]; Roundabout signaling pathway [GO:0035385]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
O75096	reviewed	LRP4_HUMAN	Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)	LRP4 KIAA0816 LRP10 MEGF7	Homo sapiens (Human)	1905	FUNCTION: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VI56, ECO:0000269|PubMed:20381006, ECO:0000269|PubMed:21471202}.		amyloid-beta clearance by cellular catabolic process [GO:0150094]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; generation of neurons [GO:0048699]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic assembly at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055]	cell surface [GO:0009986]; dendrite [GO:0030425]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060]	apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]	cell surface [GO:0009986]; dendrite [GO:0030425]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060]; apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; generation of neurons [GO:0048699]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic assembly at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VI56}; Single-pass type I membrane protein {ECO:0000255}.
O75106	reviewed	AOC2_HUMAN	Retina-specific copper amine oxidase (RAO) (EC 1.4.3.21) (Amine oxidase [copper-containing]) (Semicarbazide-sensitive amine oxidase) (SSAO)	AOC2	Homo sapiens (Human)	756	FUNCTION: Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076}.		amine metabolic process [GO:0009308]; catecholamine metabolic process [GO:0006584]; visual perception [GO:0007601]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	aminoacetone:oxygen oxidoreductase(deaminating) activity [GO:0052594]; copper ion binding [GO:0005507]; electron transfer activity [GO:0009055]; phenethylamine:oxygen oxidoreductase (deaminating) activity [GO:0052596]; primary amine oxidase activity [GO:0008131]; quinone binding [GO:0048038]; tryptamine:oxygen oxidoreductase (deaminating) activity [GO:0052593]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; aminoacetone:oxygen oxidoreductase(deaminating) activity [GO:0052594]; copper ion binding [GO:0005507]; electron transfer activity [GO:0009055]; phenethylamine:oxygen oxidoreductase (deaminating) activity [GO:0052596]; primary amine oxidase activity [GO:0008131]; quinone binding [GO:0048038]; tryptamine:oxygen oxidoreductase (deaminating) activity [GO:0052593]; amine metabolic process [GO:0009308]; catecholamine metabolic process [GO:0006584]; visual perception [GO:0007601]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:19588076}; Peripheral membrane protein {ECO:0000269|PubMed:19588076}. Note=Present on the surface of the cells. {ECO:0000269|PubMed:19588076}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19588076}. Note=Either not translocated to the plasma membrane or below detection level. {ECO:0000269|PubMed:19588076}.
O75110	reviewed	ATP9A_HUMAN	Probable phospholipid-transporting ATPase IIA (EC 7.6.2.1) (ATPase class II type 9A)	ATP9A ATPIIA KIAA0611	Homo sapiens (Human)	1047	FUNCTION: Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation (PubMed:27733620, PubMed:30213940, PubMed:36604604). Also involved in endosome to trans-Golgi network retrograde transport (PubMed:27733620, PubMed:30213940). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation (PubMed:30213940). Appears to be implicated in intercellular communication by negatively regulating the release of exosomes (PubMed:30947313). The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved (PubMed:30947313). Required for the maintenance of neurite morphology and synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O70228, ECO:0000269|PubMed:27733620, ECO:0000269|PubMed:30213940, ECO:0000269|PubMed:30947313, ECO:0000269|PubMed:36604604}.		endocytosis [GO:0006897]; negative regulation of exosomal secretion [GO:1903542]; neuron projection morphogenesis [GO:0048812]; phospholipid translocation [GO:0045332]; regulation of endocytic recycling [GO:2001135]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; protease binding [GO:0002020]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; protease binding [GO:0002020]; endocytosis [GO:0006897]; negative regulation of exosomal secretion [GO:1903542]; neuron projection morphogenesis [GO:0048812]; phospholipid translocation [GO:0045332]; regulation of endocytic recycling [GO:2001135]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:27733620, ECO:0000269|PubMed:30213940}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:27733620}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:36604604}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:27733620, ECO:0000269|PubMed:30213940}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30947313}; Multi-pass membrane protein. Note=Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B (PubMed:21914794). Transiently expressed in the cell membrane (PubMed:30947313). {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:30947313}.
O75112	reviewed	LDB3_HUMAN	LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein)	LDB3 KIAA0613 ZASP	Homo sapiens (Human)	727	FUNCTION: May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}.		actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]; sarcomere organization [GO:0045214]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; filamentous actin [GO:0031941]; perinuclear region of cytoplasm [GO:0048471]; pseudopodium [GO:0031143]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein kinase C binding [GO:0005080]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; filamentous actin [GO:0031941]; perinuclear region of cytoplasm [GO:0048471]; pseudopodium [GO:0031143]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein kinase C binding [GO:0005080]; actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]; sarcomere organization [GO:0045214]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10427098}. Cell projection, pseudopodium {ECO:0000269|PubMed:10427098}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10427098}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:10427098}. Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
O75113	reviewed	N4BP1_HUMAN	NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-)	N4BP1 KIAA0615	Homo sapiens (Human)	896	FUNCTION: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}.		cellular response to UV [GO:0034644]; innate immune response [GO:0045087]; negative regulation of cytokine production [GO:0001818]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of viral genome replication [GO:0045071]; regulation of innate immune response [GO:0045088]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; PML body [GO:0016605]	mRNA binding [GO:0003729]; RNA nuclease activity [GO:0004540]; ubiquitin binding [GO:0043130]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; PML body [GO:0016605]; mRNA binding [GO:0003729]; RNA nuclease activity [GO:0004540]; ubiquitin binding [GO:0043130]; cellular response to UV [GO:0034644]; innate immune response [GO:0045087]; negative regulation of cytokine production [GO:0001818]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of viral genome replication [GO:0045071]; regulation of innate immune response [GO:0045088]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6A037}. Nucleus {ECO:0000250|UniProtKB:Q6A037}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q6A037}. Nucleus, PML body {ECO:0000250|UniProtKB:Q6A037}. Note=Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated. {ECO:0000250|UniProtKB:Q6A037}.
O75116	reviewed	ROCK2_HUMAN	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)	ROCK2 KIAA0619	Homo sapiens (Human)	1388	FUNCTION: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}.		actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; aortic valve morphogenesis [GO:0003180]; blood vessel diameter maintenance [GO:0097746]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to acetylcholine [GO:1905145]; cellular response to testosterone stimulus [GO:0071394]; centrosome duplication [GO:0051298]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; epithelial to mesenchymal transition [GO:0001837]; mitotic cytokinesis [GO:0000281]; modulation by host of viral process [GO:0044788]; mRNA destabilization [GO:0061157]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of gene expression [GO:0010629]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein localization to lysosome [GO:0150033]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell migration [GO:0030335]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of connective tissue growth factor production [GO:0032723]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of cell adhesion [GO:0030155]; regulation of cell junction assembly [GO:1901888]; regulation of cell motility [GO:2000145]; regulation of cellular response to hypoxia [GO:1900037]; regulation of circadian rhythm [GO:0042752]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of nervous system process [GO:0031644]; regulation of protein metabolic process [GO:0051246]; regulation of stress fiber assembly [GO:0051492]; response to angiotensin [GO:1990776]; response to ischemia [GO:0002931]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; rhythmic process [GO:0048511]; smooth muscle contraction [GO:0006939]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; aortic valve morphogenesis [GO:0003180]; blood vessel diameter maintenance [GO:0097746]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to acetylcholine [GO:1905145]; cellular response to testosterone stimulus [GO:0071394]; centrosome duplication [GO:0051298]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; epithelial to mesenchymal transition [GO:0001837]; mitotic cytokinesis [GO:0000281]; modulation by host of viral process [GO:0044788]; mRNA destabilization [GO:0061157]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of gene expression [GO:0010629]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein localization to lysosome [GO:0150033]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell migration [GO:0030335]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of connective tissue growth factor production [GO:0032723]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of cell adhesion [GO:0030155]; regulation of cell junction assembly [GO:1901888]; regulation of cell motility [GO:2000145]; regulation of cellular response to hypoxia [GO:1900037]; regulation of circadian rhythm [GO:0042752]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of nervous system process [GO:0031644]; regulation of protein metabolic process [GO:0051246]; regulation of stress fiber assembly [GO:0051492]; response to angiotensin [GO:1990776]; response to ischemia [GO:0002931]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; rhythmic process [GO:0048511]; smooth muscle contraction [GO:0006939]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane. {ECO:0000250}.
O75121	reviewed	MFA3L_HUMAN	Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9)	MFAP3L KIAA0626 HSD-39 HSD39	Homo sapiens (Human)	409	FUNCTION: May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. {ECO:0000269|PubMed:24735981}.			cell junction [GO:0030054]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		cell junction [GO:0030054]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24735981}; Single-pass type I membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:24735981}. Cytoplasm {ECO:0000269|PubMed:24735981}. Note=Mainly localized in the nucleus (PubMed:24735981). {ECO:0000269|PubMed:24735981}.
O75122	reviewed	CLAP2_HUMAN	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2)	CLASP2 KIAA0627	Homo sapiens (Human)	1294	FUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.		cell division [GO:0051301]; establishment of mitotic spindle localization [GO:0040001]; establishment or maintenance of cell polarity [GO:0007163]; exit from mitosis [GO:0010458]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; protein localization to plasma membrane [GO:0072659]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axon extension [GO:0030516]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; regulation of microtubule-based process [GO:0032886]; vesicle targeting [GO:0006903]	axonal growth cone [GO:0044295]; basal cortex [GO:0045180]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cortical microtubule plus-end [GO:1903754]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; spindle microtubule [GO:0005876]; trans-Golgi network [GO:0005802]	actin filament binding [GO:0051015]; dystroglycan binding [GO:0002162]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein tyrosine kinase binding [GO:1990782]	axonal growth cone [GO:0044295]; basal cortex [GO:0045180]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cortical microtubule plus-end [GO:1903754]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; spindle microtubule [GO:0005876]; trans-Golgi network [GO:0005802]; actin filament binding [GO:0051015]; dystroglycan binding [GO:0002162]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein tyrosine kinase binding [GO:1990782]; cell division [GO:0051301]; establishment of mitotic spindle localization [GO:0040001]; establishment or maintenance of cell polarity [GO:0007163]; exit from mitosis [GO:0010458]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; protein localization to plasma membrane [GO:0072659]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axon extension [GO:0030516]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; regulation of microtubule-based process [GO:0032886]; vesicle targeting [GO:0006903]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:20937854}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16914514}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514}. Golgi apparatus {ECO:0000250|UniProtKB:Q8BRT1}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:17543864}. Cell membrane {ECO:0000269|PubMed:20937854}. Cell projection, ruffle membrane {ECO:0000269|PubMed:20937854}. Note=Localizes to microtubule plus ends (PubMed:15631994). Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase (PubMed:16866869, PubMed:16914514). In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2 (PubMed:16824950). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane. {ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:20937854}.
O75127	reviewed	PTCD1_HUMAN	Pentatricopeptide repeat-containing protein 1, mitochondrial	PTCD1 KIAA0632	Homo sapiens (Human)	700	FUNCTION: Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs. {ECO:0000269|PubMed:21857155}.		mitochondrial translation [GO:0032543]; tRNA 3'-end processing [GO:0042780]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; tRNA binding [GO:0000049]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]; mitochondrial translation [GO:0032543]; tRNA 3'-end processing [GO:0042780]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19651879, ECO:0000269|PubMed:21857155}. Mitochondrion matrix {ECO:0000250}.
O75128	reviewed	COBL_HUMAN	Protein cordon-bleu	COBL KIAA0633	Homo sapiens (Human)	1261	FUNCTION: Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}.		actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; collateral sprouting in absence of injury [GO:0048669]; digestive tract development [GO:0048565]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; liver development [GO:0001889]; neural tube closure [GO:0001843]; notochord development [GO:0030903]; positive regulation of dendrite development [GO:1900006]; positive regulation of ruffle assembly [GO:1900029]; somite specification [GO:0001757]	actin filament [GO:0005884]; axon [GO:0030424]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; dendrite [GO:0030425]; dendritic growth cone [GO:0044294]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; terminal web [GO:1990357]	actin monomer binding [GO:0003785]	actin filament [GO:0005884]; axon [GO:0030424]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; dendrite [GO:0030425]; dendritic growth cone [GO:0044294]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; terminal web [GO:1990357]; actin monomer binding [GO:0003785]; actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; collateral sprouting in absence of injury [GO:0048669]; digestive tract development [GO:0048565]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; liver development [GO:0001889]; neural tube closure [GO:0001843]; notochord development [GO:0030903]; positive regulation of dendrite development [GO:1900006]; positive regulation of ruffle assembly [GO:1900029]; somite specification [GO:0001757]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Recruited to the cell membrane via interaction with PACSIN1. Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites (By similarity). {ECO:0000250}.
O75129	reviewed	ASTN2_HUMAN	Astrotactin-2	ASTN2 KIAA0634	Homo sapiens (Human)	1339	FUNCTION: Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6). {ECO:0000250|UniProtKB:Q80Z10, ECO:0000269|Ref.6}.		establishment of body hair planar orientation [GO:0048105]; negative regulation of protein localization to cell surface [GO:2000009]; neuron cell-cell adhesion [GO:0007158]; neuron migration [GO:0001764]; protein localization to cell surface [GO:0034394]; protein transport [GO:0015031]	cell cortex [GO:0005938]; cell pole [GO:0060187]; clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome [GO:0005770]; membrane [GO:0016020]; perikaryon [GO:0043204]	calcium ion binding [GO:0005509]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]	cell cortex [GO:0005938]; cell pole [GO:0060187]; clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome [GO:0005770]; membrane [GO:0016020]; perikaryon [GO:0043204]; calcium ion binding [GO:0005509]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; establishment of body hair planar orientation [GO:0048105]; negative regulation of protein localization to cell surface [GO:2000009]; neuron cell-cell adhesion [GO:0007158]; neuron migration [GO:0001764]; protein localization to cell surface [GO:0034394]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q80Z10}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80Z10}. Perikaryon {ECO:0000250|UniProtKB:Q80Z10}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q80Z10}. Early endosome {ECO:0000250|UniProtKB:Q80Z10}. Late endosome {ECO:0000250|UniProtKB:Q80Z10}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q80Z10}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q80Z10}. Note=Integral membrane protein not detected at the cell membrane. Detected in cytoplasmic vesicles in the cell cortex, close to the anterior pole of migrating neurons. Detected at the base of the leading process in migrating neurons. {ECO:0000250|UniProtKB:Q80Z10}.
O75131	reviewed	CPNE3_HUMAN	Copine-3 (Copine III)	CPNE3 CPN3 KIAA0636	Homo sapiens (Human)	537	FUNCTION: Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870). {ECO:0000269|PubMed:20010870}.		cellular response to calcium ion [GO:0071277]; cellular response to growth factor stimulus [GO:0071363]; ERBB2 signaling pathway [GO:0038128]; positive regulation of cell migration [GO:0030335]	azurophil granule membrane [GO:0035577]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]	azurophil granule membrane [GO:0035577]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]; cellular response to calcium ion [GO:0071277]; cellular response to growth factor stimulus [GO:0071363]; ERBB2 signaling pathway [GO:0038128]; positive regulation of cell migration [GO:0030335]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20010870, ECO:0000269|PubMed:21087455}. Cytoplasm {ECO:0000269|PubMed:12949241, ECO:0000269|PubMed:20010870, ECO:0000269|PubMed:21087455}. Cell membrane {ECO:0000269|PubMed:20010870, ECO:0000269|PubMed:21087455}. Cell junction {ECO:0000269|PubMed:20010870}. Cell junction, focal adhesion {ECO:0000269|PubMed:20010870}. Note=Associates to the membrane in a calcium-dependent manner (PubMed:20010870). Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870). {ECO:0000269|PubMed:20010870, ECO:0000269|PubMed:21087455}.
O75132	reviewed	ZBED4_HUMAN	Zinc finger BED domain-containing protein 4	ZBED4 KIAA0637	Homo sapiens (Human)	1171	FUNCTION: Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (By similarity). {ECO:0000250|UniProtKB:Q80WQ9}.		positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17209048, ECO:0000269|PubMed:19369242, ECO:0000269|PubMed:22693546}. Cytoplasm {ECO:0000269|PubMed:17209048, ECO:0000269|PubMed:22693546}. Photoreceptor inner segment {ECO:0000269|PubMed:19369242}.
O75140	reviewed	DEPD5_HUMAN	GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5)	DEPDC5 KIAA0645	Homo sapiens (Human)	1603	FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719, PubMed:31548394, PubMed:29590090, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29769719, PubMed:29590090, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}.	MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to amino acid starvation [GO:0034198]; intracellular signal transduction [GO:0035556]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]	cytosol [GO:0005829]; GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]	GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]; cellular response to amino acid starvation [GO:0034198]; intracellular signal transduction [GO:0035556]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28199306}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P61460}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P61460}. Note=Localization to lysosomes is mediated by the KICSTOR complex and is amino acid-independent. {ECO:0000269|PubMed:28199306}.
O75143	reviewed	ATG13_HUMAN	Autophagy-related protein 13	ATG13 KIAA0652	Homo sapiens (Human)	517	FUNCTION: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}.		autophagosome assembly [GO:0000045]; mitophagy [GO:0000423]; negative regulation of cell population proliferation [GO:0008285]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein localization to phagophore assembly site [GO:0034497]; regulation of protein lipidation [GO:1903059]; response to mitochondrial depolarisation [GO:0098780]	Atg1/ULK1 kinase complex [GO:1990316]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]	protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]	Atg1/ULK1 kinase complex [GO:1990316]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; autophagosome assembly [GO:0000045]; mitophagy [GO:0000423]; negative regulation of cell population proliferation [GO:0008285]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein localization to phagophore assembly site [GO:0034497]; regulation of protein lipidation [GO:1903059]; response to mitochondrial depolarisation [GO:0098780]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19211835}. Preautophagosomal structure {ECO:0000269|PubMed:19211835}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. {ECO:0000269|PubMed:19211835}.
O75144	reviewed	ICOSL_HUMAN	ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)	ICOSLG B7H2 B7RP1 ICOSL KIAA0653	Homo sapiens (Human)	302	FUNCTION: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). {ECO:0000250}.		adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; defense response [GO:0006952]; hyperosmotic response [GO:0006972]; positive regulation of activated T cell proliferation [GO:0042104]; regulation of cytokine production [GO:0001817]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; defense response [GO:0006952]; hyperosmotic response [GO:0006972]; positive regulation of activated T cell proliferation [GO:0042104]; regulation of cytokine production [GO:0001817]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11007762}; Single-pass type I membrane protein {ECO:0000255}.
O75145	reviewed	LIPA3_HUMAN	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3)	PPFIA3 KIAA0654	Homo sapiens (Human)	1194	FUNCTION: May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}.	MISCELLANEOUS: [Isoform 2]: May be due to exon skipping. {ECO:0000305}.	neurotransmitter secretion [GO:0007269]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synapse organization [GO:0050808]; synaptic vesicle docking [GO:0016081]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; epididymosome [GO:0098875]; glutamatergic synapse [GO:0098978]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]		acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; epididymosome [GO:0098875]; glutamatergic synapse [GO:0098978]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; neurotransmitter secretion [GO:0007269]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synapse organization [GO:0050808]; synaptic vesicle docking [GO:0016081]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q91Z79}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:23124857}. Note=Also detected in epididymosome. {ECO:0000250|UniProtKB:Q91Z79}.
O75146	reviewed	HIP1R_HUMAN	Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12)	HIP1R HIP12 KIAA0655	Homo sapiens (Human)	1068	FUNCTION: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}.		actin filament organization [GO:0007015]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; clathrin coat assembly [GO:0048268]; digestive system development [GO:0055123]; endocytosis [GO:0006897]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; positive regulation of apoptotic process [GO:0043065]; positive regulation of clathrin coat assembly [GO:1905445]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; positive regulation of protein binding [GO:0032092]; postsynapse organization [GO:0099173]; protein stabilization [GO:0050821]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of clathrin-dependent endocytosis [GO:2000369]; regulation of endocytosis [GO:0030100]; regulation of gastric acid secretion [GO:0060453]	apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587]; synaptic membrane [GO:0097060]	actin filament binding [GO:0051015]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; clathrin light chain binding [GO:0032051]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SH3 domain binding [GO:0017124]	apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587]; synaptic membrane [GO:0097060]; actin filament binding [GO:0051015]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; clathrin light chain binding [GO:0032051]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SH3 domain binding [GO:0017124]; actin filament organization [GO:0007015]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; clathrin coat assembly [GO:0048268]; digestive system development [GO:0055123]; endocytosis [GO:0006897]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; positive regulation of apoptotic process [GO:0043065]; positive regulation of clathrin coat assembly [GO:1905445]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; positive regulation of protein binding [GO:0032092]; postsynapse organization [GO:0099173]; protein stabilization [GO:0050821]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of clathrin-dependent endocytosis [GO:2000369]; regulation of endocytosis [GO:0030100]; regulation of gastric acid secretion [GO:0060453]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
O75147	reviewed	OBSL1_HUMAN	Obscurin-like protein 1	OBSL1 KIAA0657	Homo sapiens (Human)	1896	FUNCTION: Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. {ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}.		cardiac myofibril assembly [GO:0055003]; cytoskeleton organization [GO:0007010]; Golgi organization [GO:0007030]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of dendrite morphogenesis [GO:0050775]; protein localization to Golgi apparatus [GO:0034067]; regulation of mitotic nuclear division [GO:0007088]	3M complex [GO:1990393]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; M band [GO:0031430]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018]	cytoskeletal anchor activity [GO:0008093]	3M complex [GO:1990393]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; M band [GO:0031430]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018]; cytoskeletal anchor activity [GO:0008093]; cardiac myofibril assembly [GO:0055003]; cytoskeleton organization [GO:0007010]; Golgi organization [GO:0007030]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of dendrite morphogenesis [GO:0050775]; protein localization to Golgi apparatus [GO:0034067]; regulation of mitotic nuclear division [GO:0007088]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24793695}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24793695}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:24793695}. Golgi apparatus {ECO:0000269|PubMed:21572988}. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons (PubMed:21572988).
O75150	reviewed	BRE1B_HUMAN	E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)	RNF40 BRE1B KIAA0661	Homo sapiens (Human)	1001	FUNCTION: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.		chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	HULC complex [GO:0033503]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]	HULC complex [GO:0033503]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10944455}.
O75151	reviewed	PHF2_HUMAN	Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2)	PHF2 CENP-35 KIAA0662	Homo sapiens (Human)	1096	FUNCTION: Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}.		liver development [GO:0001889]; negative regulation of rDNA heterochromatin formation [GO:0061188]; protein demethylation [GO:0006482]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]	kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone H3K9 demethylase activity [GO:0032454]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]	kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone H3K9 demethylase activity [GO:0032454]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]; liver development [GO:0001889]; negative regulation of rDNA heterochromatin formation [GO:0061188]; protein demethylation [GO:0006482]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:20129925}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
O75152	reviewed	ZC11A_HUMAN	Zinc finger CCCH domain-containing protein 11A	ZC3H11A KIAA0663 ZC3HDC11A	Homo sapiens (Human)	810	FUNCTION: RNA-binding protein that interacts with purine-rich sequences and is involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA Export. {ECO:0000269|PubMed:29610341}.		poly(A)+ mRNA export from nucleus [GO:0016973]	nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; poly(A)+ mRNA export from nucleus [GO:0016973]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29610341}.
O75154	reviewed	RFIP3_HUMAN	Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148)	RAB11FIP3 ARFO1 KIAA0665	Homo sapiens (Human)	756	FUNCTION: Downstream effector molecule for Rab11 GTPase which acts as a regulator of endocytic trafficking and intracellular ciliogenesis by participating in membrane delivery (PubMed:16148947, PubMed:15601896, PubMed:17628206, PubMed:17394487, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex then regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is also needed to regulates the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport and fusion of vesicles derived from recycling endosomes to the cleavage furrow during late cytokinesis and abscission (PubMed:16148947, PubMed:15601896). Also regulates cleavage furrow ingression and abscission together with RACGAP1 (PubMed:18511905). Required for ARF6 recruitment to the cleavage furrow during cytokinesis (PubMed:17628206). Involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867). {ECO:0000250|UniProtKB:Q8CHD8, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:17628206, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19327867, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26258637, ECO:0000269|PubMed:31204173}.		cell cycle [GO:0007049]; cell division [GO:0051301]; endocytic recycling [GO:0032456]; negative regulation of adiponectin secretion [GO:0070164]; protein localization to cilium [GO:0061512]; regulation of cilium assembly [GO:1902017]; regulation of cytokinesis [GO:0032465]; regulation of early endosome to recycling endosome transport [GO:1902954]; regulation of endocytic recycling [GO:2001135]; regulation of protein localization to centrosome [GO:1904779]; regulation of vesicle-mediated transport [GO:0060627]; vesicle-mediated transport [GO:0016192]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endocytic vesicle membrane [GO:0030666]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; postsynaptic recycling endosome membrane [GO:0098944]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]	calcium ion binding [GO:0005509]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endocytic vesicle membrane [GO:0030666]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; postsynaptic recycling endosome membrane [GO:0098944]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]; calcium ion binding [GO:0005509]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; cell cycle [GO:0007049]; cell division [GO:0051301]; endocytic recycling [GO:0032456]; negative regulation of adiponectin secretion [GO:0070164]; protein localization to cilium [GO:0061512]; regulation of cilium assembly [GO:1902017]; regulation of cytokinesis [GO:0032465]; regulation of early endosome to recycling endosome transport [GO:1902954]; regulation of endocytic recycling [GO:2001135]; regulation of protein localization to centrosome [GO:1904779]; regulation of vesicle-mediated transport [GO:0060627]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Endosome membrane. Recycling endosome membrane {ECO:0000269|PubMed:11495908, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:17007872, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:20026645}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15158446, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:18511905}. Cleavage furrow {ECO:0000269|PubMed:15158446, ECO:0000269|PubMed:15601896}. Midbody {ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:18511905}. Golgi apparatus membrane {ECO:0000269|PubMed:25673879}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:25673879}; Peripheral membrane protein {ECO:0000305}. Note=During interphase, localized in vesicles continuously moving from peripheral sorting endosomes in the cell towards the pericentrosomal endosomal recycling compartment (ERC) (PubMed:17394487, PubMed:20026645). In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission (PubMed:15158446, PubMed:15601896, PubMed:18511905). Interaction with Rab11 mediates localization to endosomes (PubMed:11495908). Interaction with ARF6 mediates localization to the midbody (PubMed:16148947). Localized to the Golgi and TGN when interacting with RHO in photoreceptors (PubMed:25673879). Localized to rhodopsin transport carriers when interacting with RAB11A and ASAP1 in photoreceptors (PubMed:25673879). {ECO:0000269|PubMed:11495908, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25673879}.
O75155	reviewed	CAND2_HUMAN	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (Epididymis tissue protein Li 169) (TBP-interacting protein of 120 kDa B) (TBP-interacting protein 120B) (p120 CAND2)	CAND2 KIAA0667 TIP120B	Homo sapiens (Human)	1236	FUNCTION: Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. {ECO:0000250}.		positive regulation of DNA-templated transcription [GO:0045893]; protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265]	cytosol [GO:0005829]; nucleus [GO:0005634]	TBP-class protein binding [GO:0017025]	cytosol [GO:0005829]; nucleus [GO:0005634]; TBP-class protein binding [GO:0017025]; positive regulation of DNA-templated transcription [GO:0045893]; protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
O75159	reviewed	SOCS5_HUMAN	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5)	SOCS5 CIS6 CISH5 CISH6 KIAA0671	Homo sapiens (Human)	536	FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. {ECO:0000269|PubMed:15590694}.		cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular signal transduction [GO:0035556]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of signal transduction [GO:0009968]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; protein ubiquitination [GO:0016567]; receptor signaling pathway via JAK-STAT [GO:0007259]; vascular endothelial cell response to fluid shear stress [GO:0097699]	cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; epidermal growth factor receptor binding [GO:0005154]; receptor tyrosine kinase binding [GO:0030971]	cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; epidermal growth factor receptor binding [GO:0005154]; receptor tyrosine kinase binding [GO:0030971]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular signal transduction [GO:0035556]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of signal transduction [GO:0009968]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; protein ubiquitination [GO:0016567]; receptor signaling pathway via JAK-STAT [GO:0007259]; vascular endothelial cell response to fluid shear stress [GO:0097699]	
O75161	reviewed	NPHP4_HUMAN	Nephrocystin-4 (Nephroretinin)	NPHP4 KIAA0673	Homo sapiens (Human)	1426	FUNCTION: Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250|UniProtKB:B0DOB4, ECO:0000250|UniProtKB:P59240, ECO:0000269|PubMed:21498478, ECO:0000269|PubMed:21555462, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22654112, ECO:0000305|PubMed:19755384}.		actin cytoskeleton organization [GO:0030036]; cell-cell adhesion [GO:0098609]; flagellated sperm motility [GO:0030317]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of bicellular tight junction assembly [GO:1903348]; protein localization to ciliary transition zone [GO:1904491]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; visual behavior [GO:0007632]	bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; non-motile cilium [GO:0097730]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; photoreceptor distal connecting cilium [GO:0120206]; ribbon synapse [GO:0097470]	structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; non-motile cilium [GO:0097730]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; photoreceptor distal connecting cilium [GO:0120206]; ribbon synapse [GO:0097470]; structural molecule activity [GO:0005198]; actin cytoskeleton organization [GO:0030036]; cell-cell adhesion [GO:0098609]; flagellated sperm motility [GO:0030317]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of bicellular tight junction assembly [GO:1903348]; protein localization to ciliary transition zone [GO:1904491]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; visual behavior [GO:0007632]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17558407, ECO:0000269|PubMed:26644512}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17558407}. Cell junction, tight junction {ECO:0000250|UniProtKB:P59240}. Nucleus {ECO:0000269|PubMed:22654112}. Note=In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions (By similarity). Localizes to the ciliary transition zone (By similarity). In the retinal photoreceptor cell layer, localizes at the connecting cilium (By similarity). {ECO:0000250|UniProtKB:P59240}.
O75164	reviewed	KDM4A_HUMAN	Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A)	KDM4A JHDM3A JMJD2 JMJD2A KIAA0677	Homo sapiens (Human)	1064	FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}.		apoptotic chromosome condensation [GO:0030263]; cardiac muscle hypertrophy in response to stress [GO:0014898]; chromatin remodeling [GO:0006338]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; regulation of gene expression [GO:0010468]; response to nutrient levels [GO:0031667]	chromatin [GO:0000785]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me2/H3K36me3 demethylase activity [GO:0140681]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; methylated histone binding [GO:0035064]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me2/H3K36me3 demethylase activity [GO:0140681]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; methylated histone binding [GO:0035064]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; apoptotic chromosome condensation [GO:0030263]; cardiac muscle hypertrophy in response to stress [GO:0014898]; chromatin remodeling [GO:0006338]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; regulation of gene expression [GO:0010468]; response to nutrient levels [GO:0031667]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16024779}.
O75165	reviewed	DJC13_HUMAN	DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8) (RME-8)	DNAJC13 KIAA0678 RME8	Homo sapiens (Human)	2243	FUNCTION: Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates the dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499). {ECO:0000269|PubMed:18256511, ECO:0000269|PubMed:18307993, ECO:0000269|PubMed:24643499}.		endosome organization [GO:0007032]; osteoblast differentiation [GO:0001649]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of early endosome to recycling endosome transport [GO:1902954]	azurophil granule membrane [GO:0035577]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]		azurophil granule membrane [GO:0035577]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; endosome organization [GO:0007032]; osteoblast differentiation [GO:0001649]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of early endosome to recycling endosome transport [GO:1902954]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:18256511}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000269|PubMed:18256511}. Endosome membrane {ECO:0000269|PubMed:24643499}.
O75167	reviewed	PHAR2_HUMAN	Phosphatase and actin regulator 2	PHACTR2 C6orf56 KIAA0680	Homo sapiens (Human)	634			actin cytoskeleton organization [GO:0030036]	plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864]	plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864]; actin cytoskeleton organization [GO:0030036]	SUBCELLULAR LOCATION: [Isoform 2]: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
O75170	reviewed	PP6R2_HUMAN	Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2)	PPP6R2 KIAA0685 PP6R2 SAPS2	Homo sapiens (Human)	966	FUNCTION: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}.			cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleus [GO:0005634]	protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16769727}.
O75173	reviewed	ATS4_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1)	ADAMTS4 KIAA0688 UNQ769/PRO1563	Homo sapiens (Human)	837	FUNCTION: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.	MISCELLANEOUS: [Isoform 2]: Functional aggrecanase. {ECO:0000269|PubMed:23897278}.	extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]; skeletal system development [GO:0001501]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nuclear speck [GO:0016607]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nuclear speck [GO:0016607]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
O75175	reviewed	CNOT3_HUMAN	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2)	CNOT3 KIAA0691 LENG2 NOT3	Homo sapiens (Human)	753	FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:22342980, ECO:0000269|PubMed:22367759}.		nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell population maintenance [GO:2000036]; regulatory ncRNA-mediated gene silencing [GO:0031047]; trophectodermal cell differentiation [GO:0001829]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]		CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell population maintenance [GO:2000036]; regulatory ncRNA-mediated gene silencing [GO:0031047]; trophectodermal cell differentiation [GO:0001829]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
O75177	reviewed	CREST_HUMAN	Calcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1)	SS18L1 CREST KIAA0693	Homo sapiens (Human)	396	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.		chromatin organization [GO:0006325]; dendrite development [GO:0016358]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytosol [GO:0005829]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; chromatin organization [GO:0006325]; dendrite development [GO:0016358]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity). {ECO:0000250}.
O75179	reviewed	ANR17_HUMAN	Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16)	ANKRD17 GTAR KIAA0697	Homo sapiens (Human)	2603	FUNCTION: Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.		blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; RNA binding [GO:0003723]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; RNA binding [GO:0003723]; blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:22328336}. Nucleus {ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336}. Note=Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner. {ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984}.
O75182	reviewed	SIN3B_HUMAN	Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)	SIN3B KIAA0700	Homo sapiens (Human)	1162	FUNCTION: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. {ECO:0000250|UniProtKB:Q62141}.		negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]	autosome [GO:0030849]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; X chromosome [GO:0000805]; XY body [GO:0001741]; Y chromosome [GO:0000806]	chromatin binding [GO:0003682]; transcription corepressor activity [GO:0003714]	autosome [GO:0030849]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; X chromosome [GO:0000805]; XY body [GO:0001741]; Y chromosome [GO:0000806]; chromatin binding [GO:0003682]; transcription corepressor activity [GO:0003714]; negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810}.
O75185	reviewed	AT2C2_HUMAN	Calcium-transporting ATPase type 2C member 2 (ATPase 2C2) (EC 7.2.2.10) (Ca(2+)/Mn(2+)-ATPase 2C2) (Secretory pathway Ca(2+)-transporting ATPase type 2) (SPCA2)	ATP2C2 KIAA0703 SPCA2	Homo sapiens (Human)	946	FUNCTION: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:15831496, PubMed:16332677, PubMed:30923126, PubMed:15677451). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:15831496, PubMed:16332677). Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus (PubMed:23840669, PubMed:20887894). {ECO:0000269|PubMed:15677451, ECO:0000269|PubMed:15831496, ECO:0000269|PubMed:16332677, ECO:0000269|PubMed:20887894, ECO:0000269|PubMed:23840669, ECO:0000269|PubMed:30923126}.		calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; mammary gland epithelium development [GO:0061180]; manganese ion transport [GO:0006828]; positive regulation of calcium ion import [GO:0090280]; protein localization to plasma membrane [GO:0072659]	basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type manganese transporter activity [GO:0140613]	basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type manganese transporter activity [GO:0140613]; calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; mammary gland epithelium development [GO:0061180]; manganese ion transport [GO:0006828]; positive regulation of calcium ion import [GO:0090280]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15831496}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:20887894}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:A7L9Z8}; Multi-pass membrane protein {ECO:0000255}.
O75190	reviewed	DNJB6_HUMAN	DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1)	DNAJB6 HSJ2 MRJ MSJ1	Homo sapiens (Human)	326	FUNCTION: Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 (PubMed:10954706, PubMed:28233300). Plays an indispensable role in the organization of KRT8/KRT18 filaments (PubMed:10954706). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed:11896048, PubMed:22366786). Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (PubMed:20159555, PubMed:22366786). Also reduces cellular toxicity and caspase-3 activity (PubMed:11896048). {ECO:0000269|PubMed:10954706, ECO:0000269|PubMed:11896048, ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786, ECO:0000269|PubMed:28233300}.; FUNCTION: [Isoform B]: Isoform B but not isoform A inhibits huntingtin aggregation. {ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786}.		actin cytoskeleton organization [GO:0030036]; chaperone-mediated protein folding [GO:0061077]; chorio-allantoic fusion [GO:0060710]; chorion development [GO:0060717]; extracellular matrix organization [GO:0030198]; intermediate filament organization [GO:0045109]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]; protein localization to nucleus [GO:0034504]; regulation of cellular response to heat [GO:1900034]; regulation of protein localization [GO:0032880]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018]	ATPase activator activity [GO:0001671]; DNA binding [GO:0003677]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018]; ATPase activator activity [GO:0001671]; DNA binding [GO:0003677]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; actin cytoskeleton organization [GO:0030036]; chaperone-mediated protein folding [GO:0061077]; chorio-allantoic fusion [GO:0060710]; chorion development [GO:0060717]; extracellular matrix organization [GO:0030198]; intermediate filament organization [GO:0045109]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]; protein localization to nucleus [GO:0034504]; regulation of cellular response to heat [GO:1900034]; regulation of protein localization [GO:0032880]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10954706}. Nucleus {ECO:0000269|PubMed:10954706}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:22366786}.
O75191	reviewed	XYLB_HUMAN	Xylulose kinase (Xylulokinase) (EC 2.7.1.17)	XYLB	Homo sapiens (Human)	536	FUNCTION: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. {ECO:0000269|PubMed:23179721}.		carbohydrate metabolic process [GO:0005975]; D-xylose metabolic process [GO:0042732]; generation of precursor metabolites and energy [GO:0006091]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; phosphorylation [GO:0016310]; xylulose catabolic process [GO:0005998]; xylulose metabolic process [GO:0005997]	cytosol [GO:0005829]	ATP binding [GO:0005524]; xylulokinase activity [GO:0004856]	cytosol [GO:0005829]; ATP binding [GO:0005524]; xylulokinase activity [GO:0004856]; carbohydrate metabolic process [GO:0005975]; D-xylose metabolic process [GO:0042732]; generation of precursor metabolites and energy [GO:0006091]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; phosphorylation [GO:0016310]; xylulose catabolic process [GO:0005998]; xylulose metabolic process [GO:0005997]	
O75192	reviewed	PX11A_HUMAN	Peroxisomal membrane protein 11A (HsPEX11p) (28 kDa peroxisomal integral membrane protein) (PMP28) (Peroxin-11A) (Peroxisomal biogenesis factor 11A) (Protein PEX11 homolog alpha) (PEX11-alpha)	PEX11A PEX11	Homo sapiens (Human)	247	FUNCTION: May be involved in peroxisomal proliferation and may regulate peroxisomes division (PubMed:9792670). May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455). {ECO:0000250|UniProtKB:O70597, ECO:0000269|PubMed:20826455, ECO:0000269|PubMed:9792670}.		brown fat cell differentiation [GO:0050873]; peroxisome fission [GO:0016559]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; regulation of peroxisome size [GO:0044375]; signal transduction [GO:0007165]	peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	protein homodimerization activity [GO:0042803]	peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; protein homodimerization activity [GO:0042803]; brown fat cell differentiation [GO:0050873]; peroxisome fission [GO:0016559]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; regulation of peroxisome size [GO:0044375]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:20826455, ECO:0000269|PubMed:9714566, ECO:0000269|PubMed:9792670}; Multi-pass membrane protein {ECO:0000269|PubMed:9714566, ECO:0000269|PubMed:9792670}.
O75197	reviewed	LRP5_HUMAN	Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)	LRP5 LR3 LRP7	Homo sapiens (Human)	1615	FUNCTION: Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins (PubMed:11336703, PubMed:11448771, PubMed:15778503, PubMed:11719191, PubMed:15908424, PubMed:16252235). Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11336703, PubMed:11719191). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11719191). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (PubMed:11336703, PubMed:25920554, PubMed:24706814, PubMed:14731402). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (PubMed:27228167, PubMed:16252235). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (By similarity). {ECO:0000250|UniProtKB:Q91VN0, ECO:0000269|PubMed:11336703, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:11719191, ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:15908424, ECO:0000269|PubMed:16252235, ECO:0000269|PubMed:24706814, ECO:0000269|PubMed:25920554, ECO:0000269|PubMed:27228167}.		adipose tissue development [GO:0060612]; amino acid transport [GO:0006865]; anatomical structure regression [GO:0060033]; anterior/posterior pattern specification [GO:0009952]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; bone marrow development [GO:0048539]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion [GO:0098609]; cell-cell signaling involved in mammary gland development [GO:0060764]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; extracellular matrix-cell signaling [GO:0035426]; gastrulation with mouth forming second [GO:0001702]; gene expression [GO:0010467]; glucose catabolic process [GO:0006007]; mesodermal cell migration [GO:0008078]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; Norrin signaling pathway [GO:0110135]; osteoblast development [GO:0002076]; osteoblast proliferation [GO:0033687]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; response to peptide hormone [GO:0043434]; retina morphogenesis in camera-type eye [GO:0060042]; retinal blood vessel morphogenesis [GO:0061304]; somatic stem cell population maintenance [GO:0035019]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Wnt signalosome [GO:1990909]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]	coreceptor activity [GO:0015026]; coreceptor activity involved in canonical Wnt signaling pathway [GO:1904928]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Wnt signalosome [GO:1990909]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]; coreceptor activity [GO:0015026]; coreceptor activity involved in canonical Wnt signaling pathway [GO:1904928]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; adipose tissue development [GO:0060612]; amino acid transport [GO:0006865]; anatomical structure regression [GO:0060033]; anterior/posterior pattern specification [GO:0009952]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; bone marrow development [GO:0048539]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion [GO:0098609]; cell-cell signaling involved in mammary gland development [GO:0060764]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; extracellular matrix-cell signaling [GO:0035426]; gastrulation with mouth forming second [GO:0001702]; gene expression [GO:0010467]; glucose catabolic process [GO:0006007]; mesodermal cell migration [GO:0008078]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; Norrin signaling pathway [GO:0110135]; osteoblast development [GO:0002076]; osteoblast proliferation [GO:0033687]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; response to peptide hormone [GO:0043434]; retina morphogenesis in camera-type eye [GO:0060042]; retinal blood vessel morphogenesis [GO:0061304]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q91VN0}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q91VN0}. Endoplasmic reticulum {ECO:0000269|PubMed:25920554}. Note=Chaperoned to the plasma membrane by MESD. {ECO:0000250|UniProtKB:Q91VN0}.
O75204	reviewed	TM127_HUMAN	Transmembrane protein 127	TMEM127	Homo sapiens (Human)	238	FUNCTION: Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor. {ECO:0000269|PubMed:20154675}.	MISCELLANEOUS: Consistent with the observation that mTORC1 signaling regulates cell growth and size in many species, TMEM127 knockdown cells are larger and proliferate at higher rates compared to control cell lines. In contrast, cell proliferation is reduced in cells overexpressing TMEM127 (PubMed:20154675). {ECO:0000305|PubMed:20154675}.	endosome organization [GO:0007032]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of TOR signaling [GO:0032007]; regulation of TOR signaling [GO:0032006]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; membrane [GO:0016020]; plasma membrane [GO:0005886]	small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; membrane [GO:0016020]; plasma membrane [GO:0005886]; small GTPase binding [GO:0031267]; endosome organization [GO:0007032]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of TOR signaling [GO:0032007]; regulation of TOR signaling [GO:0032006]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20154675, ECO:0000269|PubMed:21156949}; Multi-pass membrane protein {ECO:0000269|PubMed:20154675}. Cytoplasm {ECO:0000269|PubMed:20154675, ECO:0000269|PubMed:21156949}. Note=Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes. {ECO:0000269|PubMed:20154675, ECO:0000269|PubMed:21156949}.
O75208	reviewed	COQ9_HUMAN	Ubiquinone biosynthesis protein COQ9, mitochondrial	COQ9 C16orf49 HSPC326 PSEC0129	Homo sapiens (Human)	318	FUNCTION: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7. {ECO:0000269|PubMed:25339443}.		mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; ubiquinone biosynthetic process [GO:0006744]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ubiquinone biosynthesis complex [GO:0110142]	lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ubiquinone biosynthesis complex [GO:0110142]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8K1Z0}.
O75223	reviewed	GGCT_HUMAN	Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21)	GGCT C7orf24 CRF21	Homo sapiens (Human)	188	FUNCTION: Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:16765912). {ECO:0000269|PubMed:16765912, ECO:0000269|PubMed:18515354}.		release of cytochrome c from mitochondria [GO:0001836]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	gamma-glutamylcyclotransferase activity [GO:0003839]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; gamma-glutamylcyclotransferase activity [GO:0003839]; protein homodimerization activity [GO:0042803]; release of cytochrome c from mitochondria [GO:0001836]	
O75251	reviewed	NDUS7_HUMAN	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 7.1.1.2) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)	NDUFS7	Homo sapiens (Human)	213	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:17275378). Essential for the catalytic activity of complex I (PubMed:17275378). {ECO:0000269|PubMed:17275378}.		aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; neuronal cell body [GO:0043025]; synaptic membrane [GO:0097060]	4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; protease binding [GO:0002020]; quinone binding [GO:0048038]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; neuronal cell body [GO:0043025]; synaptic membrane [GO:0097060]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; protease binding [GO:0002020]; quinone binding [GO:0048038]; aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000250|UniProtKB:P42026}; Matrix side {ECO:0000250|UniProtKB:P42026}.
O75293	reviewed	GA45B_HUMAN	Growth arrest and DNA damage-inducible protein GADD45 beta (Myeloid differentiation primary response protein MyD118) (Negative growth regulatory protein MyD118)	GADD45B MYD118	Homo sapiens (Human)	160	FUNCTION: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.		apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of cell cycle [GO:0051726]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of cell cycle [GO:0051726]	
O75298	reviewed	RTN2_HUMAN	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (Neuroendocrine-specific protein-like I) (NSP-like protein I) (NSPLI)	RTN2 NSPL1	Homo sapiens (Human)	545	FUNCTION: Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity (PubMed:15286784). Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface (By similarity). Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell (By similarity). {ECO:0000250|UniProtKB:O70622, ECO:0000250|UniProtKB:Q6WN19, ECO:0000269|PubMed:15286784}.	MISCELLANEOUS: [Isoform RTN2-C]: Produced by alternative initiation at Met-341 of isoform RTN2-A. {ECO:0000305}.	gene expression [GO:0010467]; intracellular protein transmembrane transport [GO:0065002]; negative regulation of amyloid-beta formation [GO:1902430]; regulation of glucose import [GO:0046324]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intermediate filament [GO:0005882]; sarcoplasmic reticulum membrane [GO:0033017]; T-tubule [GO:0030315]; terminal cisterna [GO:0014802]; Z disc [GO:0030018]		cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intermediate filament [GO:0005882]; sarcoplasmic reticulum membrane [GO:0033017]; T-tubule [GO:0030315]; terminal cisterna [GO:0014802]; Z disc [GO:0030018]; gene expression [GO:0010467]; intracellular protein transmembrane transport [GO:0065002]; negative regulation of amyloid-beta formation [GO:1902430]; regulation of glucose import [GO:0046324]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22232211}; Multi-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:O70622}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q6WN19}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:O70622}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O70622}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:O70622}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70622}. Note=Localizes to intermediate filaments in mononucleated myoblasts and to Z lines in mature myotubes. {ECO:0000250|UniProtKB:O70622}.
O75306	reviewed	NDUS2_HUMAN	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 7.1.1.2) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit)	NDUFS2	Homo sapiens (Human)	463	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30922174, PubMed:22036843). Essential for the catalytic activity of complex I (PubMed:30922174, PubMed:22036843). Essential for the assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (PubMed:30922174). Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity). {ECO:0000250|UniProtKB:Q91WD5, ECO:0000269|PubMed:22036843, ECO:0000269|PubMed:30922174}.		aerobic respiration [GO:0009060]; cellular response to oxygen levels [GO:0071453]; gliogenesis [GO:0042063]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; neural precursor cell proliferation [GO:0061351]; neurogenesis [GO:0022008]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to oxidative stress [GO:0006979]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; oxygen sensor activity [GO:0019826]; quinone binding [GO:0048038]; ubiquitin protein ligase binding [GO:0031625]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; oxygen sensor activity [GO:0019826]; quinone binding [GO:0048038]; ubiquitin protein ligase binding [GO:0031625]; aerobic respiration [GO:0009060]; cellular response to oxygen levels [GO:0071453]; gliogenesis [GO:0042063]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; neural precursor cell proliferation [GO:0061351]; neurogenesis [GO:0022008]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891, ECO:0000305|PubMed:9585441}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q641Y2}; Matrix side {ECO:0000250|UniProtKB:Q641Y2}.
O75309	reviewed	CAD16_HUMAN	Cadherin-16 (Kidney-specific cadherin) (Ksp-cadherin)	CDH16 UNQ695/PRO1340	Homo sapiens (Human)	829	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]	calcium ion binding [GO:0005509]	basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O75311	reviewed	GLRA3_HUMAN	Glycine receptor subunit alpha-3	GLRA3	Homo sapiens (Human)	464	FUNCTION: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity). {ECO:0000250|UniProtKB:P24524, ECO:0000250|UniProtKB:Q91XP5, ECO:0000269|PubMed:26416729, ECO:0000269|PubMed:9677400}.	MISCELLANEOUS: The alpha subunit binds strychnine. {ECO:0000269|PubMed:26416729}.	chloride transmembrane transport [GO:1902476]; protein homooligomerization [GO:0051260]; response to amino acid [GO:0043200]	dendrite [GO:0030425]; glycine-gated chloride channel complex [GO:0016935]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; glycine-gated chloride ion channel activity [GO:0022852]; metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	dendrite [GO:0030425]; glycine-gated chloride channel complex [GO:0016935]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; glycine-gated chloride ion channel activity [GO:0022852]; metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; chloride transmembrane transport [GO:1902476]; protein homooligomerization [GO:0051260]; response to amino acid [GO:0043200]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P24524}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:P24524}. Cell projection, dendrite {ECO:0000250|UniProtKB:P24524}. Synapse {ECO:0000250|UniProtKB:P24524}. Cell membrane {ECO:0000269|PubMed:26416729, ECO:0000269|PubMed:9677400}; Multi-pass membrane protein {ECO:0000269|PubMed:26416729}. Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. {ECO:0000250|UniProtKB:P24524}.
O75312	reviewed	ZPR1_HUMAN	Zinc finger protein ZPR1 (Zinc finger protein 259)	ZPR1 ZNF259	Homo sapiens (Human)	459	FUNCTION: Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression (PubMed:29851065). Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:17068332, ECO:0000269|PubMed:22422766, ECO:0000269|PubMed:29851065}.		apoptotic process involved in development [GO:1902742]; axon development [GO:0061564]; Cajal body organization [GO:0030576]; cell population proliferation [GO:0008283]; cellular response to epidermal growth factor stimulus [GO:0071364]; DNA endoreduplication [GO:0042023]; inner cell mass cell proliferation [GO:0001833]; microtubule cytoskeleton organization [GO:0000226]; mRNA processing [GO:0006397]; negative regulation of motor neuron apoptotic process [GO:2000672]; positive regulation of cell cycle [GO:0045787]; positive regulation of gene expression [GO:0010628]; positive regulation of growth [GO:0045927]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of RNA splicing [GO:0033120]; positive regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071931]; pre-mRNA catabolic process [GO:1990261]; regulation of myelination [GO:0031641]; RNA splicing [GO:0008380]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; trophectodermal cell proliferation [GO:0001834]	axon [GO:0030424]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; Gemini of coiled bodies [GO:0097504]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]	receptor tyrosine kinase binding [GO:0030971]; translation initiation factor binding [GO:0031369]; zinc ion binding [GO:0008270]	axon [GO:0030424]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; Gemini of coiled bodies [GO:0097504]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; receptor tyrosine kinase binding [GO:0030971]; translation initiation factor binding [GO:0031369]; zinc ion binding [GO:0008270]; apoptotic process involved in development [GO:1902742]; axon development [GO:0061564]; Cajal body organization [GO:0030576]; cell population proliferation [GO:0008283]; cellular response to epidermal growth factor stimulus [GO:0071364]; DNA endoreduplication [GO:0042023]; inner cell mass cell proliferation [GO:0001833]; microtubule cytoskeleton organization [GO:0000226]; mRNA processing [GO:0006397]; negative regulation of motor neuron apoptotic process [GO:2000672]; positive regulation of cell cycle [GO:0045787]; positive regulation of gene expression [GO:0010628]; positive regulation of growth [GO:0045927]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of RNA splicing [GO:0033120]; positive regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071931]; pre-mRNA catabolic process [GO:1990261]; regulation of myelination [GO:0031641]; RNA splicing [GO:0008380]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; trophectodermal cell proliferation [GO:0001834]	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Nucleus, gem. Nucleus, Cajal body. Cytoplasm, perinuclear region. Cytoplasm. Cell projection, axon {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity). Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner. {ECO:0000250}.
O75317	reviewed	UBP12_HUMAN	Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.4.19.12) (Deubiquitinating enzyme 12) (Ubiquitin thioesterase 12) (Ubiquitin-hydrolyzing enzyme 1) (Ubiquitin-specific-processing protease 12)	USP12 UBH1 USP12L1	Homo sapiens (Human)	370	FUNCTION: Deubiquitinating enzyme that plays various roles in the regulation of the immune response and inflammation (PubMed:19075014, PubMed:27373336). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). During TCR engagement and activation, translocates into the cytoplasm and deubiquitinates its substrates LAT and TRAT1 and prevents their lysosome-dependent degradation to stabilize the TCR signaling complex at the plasma membrane (PubMed:26811477). Plays an essential role in the selective LPS-induced macrophage response through the activation of NF-kappa-B pathway (PubMed:28063927). In addition, promotes that antiviral immune response through targeting DNA sensor IFI16 to inhibit its proteasome-dependent degradation (PubMed:37410794). Participates in the interferon signaling pathway and antiviral response independently of its deubiquitinase activity by maintaining nuclear phosphorylated STAT1 levels via inhibition of its CREBBP-mediated acetylation and subsequent dephosphorylation (PubMed:31899788). Plays an intrinsic role in promoting the differentiation, activation and proliferation of CD4(+) T-cell by activating the NF-kappa-B signaling pathway through deubiquitinating and stabilizing B-cell lymphoma/leukemia 10/BCL10 (By similarity). In myeloid-derived suppressor cells promotes the activation of the NF-kappa-B via deubiquitination and stabilization of RELA (By similarity). Regulates the 'Lys-63'-linked polyubiquitin chains of BAX and thereby modulates the mitochondrial apoptotic process (PubMed:36361894). {ECO:0000250|UniProtKB:Q9D9M2, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:24145035, ECO:0000269|PubMed:26811477, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:28063927, ECO:0000269|PubMed:31899788, ECO:0000269|PubMed:36361894, ECO:0000269|PubMed:37410794}.; FUNCTION: (Microbial infection) Forms a complex with Epstein-Barr virus protein EBNA3 which is an active deubiquitinase activity that may select specific substrates to promote B-lymphocyte transformation. {ECO:0000269|PubMed:25855980}.	MISCELLANEOUS: Knockdown of USP12 increases Akt activation. {ECO:0000269|PubMed:24145035}.	protein deubiquitination [GO:0016579]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; metal ion binding [GO:0046872]; protein deubiquitination [GO:0016579]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26811477, ECO:0000269|PubMed:30466959}. Cytoplasm {ECO:0000269|PubMed:26811477, ECO:0000269|PubMed:30466959}. Cell membrane {ECO:0000269|PubMed:30466959}. Note=Translocates from the nucleus to the cytosol on TCR stimulation, while it translocates into the nucleus in IFN signaling. {ECO:0000269|PubMed:26811477, ECO:0000269|PubMed:31899788}.
O75319	reviewed	DUS11_HUMAN	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Dual specificity protein phosphatase 11) (Phosphatase that interacts with RNA/RNP complex 1)	DUSP11 PIR1	Homo sapiens (Human)	377	FUNCTION: Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism. {ECO:0000269|PubMed:10347225, ECO:0000269|PubMed:24447265, ECO:0000269|PubMed:9685386}.		protein dephosphorylation [GO:0006470]; RNA processing [GO:0006396]	fibrillar center [GO:0001650]; intercellular bridge [GO:0045171]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	phosphatase activity [GO:0016791]; polynucleotide 5'-phosphatase activity [GO:0004651]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA binding [GO:0003723]	fibrillar center [GO:0001650]; intercellular bridge [GO:0045171]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phosphatase activity [GO:0016791]; polynucleotide 5'-phosphatase activity [GO:0004651]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA binding [GO:0003723]; protein dephosphorylation [GO:0006470]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9685386}. Nucleus speckle {ECO:0000269|PubMed:9685386}.
O75323	reviewed	NIPS2_HUMAN	Protein NipSnap homolog 2 (NipSnap2) (Glioblastoma-amplified sequence)	NIPSNAP2 GBAS	Homo sapiens (Human)	286	FUNCTION: May act as a positive regulator of L-type calcium channels. {ECO:0000250|UniProtKB:O55126}.		mitochondrion organization [GO:0007005]; oxidative phosphorylation [GO:0006119]; positive regulation of high voltage-gated calcium channel activity [GO:1901843]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; mitochondrion organization [GO:0007005]; oxidative phosphorylation [GO:0006119]; positive regulation of high voltage-gated calcium channel activity [GO:1901843]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O55126}. Mitochondrion outer membrane {ECO:0000269|PubMed:26387735}.
O75324	reviewed	SNN_HUMAN	Stannin (AG8_1)	SNN	Homo sapiens (Human)	88	FUNCTION: Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288). {ECO:0000269|PubMed:15269288, ECO:0000269|PubMed:27015288}.		response to toxic substance [GO:0009636]	cytoplasm [GO:0005737]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; metal ion binding [GO:0046872]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:15269288, ECO:0000269|PubMed:16246365}; Single-pass membrane protein {ECO:0000269|PubMed:16246365}.
O75326	reviewed	SEM7A_HUMAN	Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108)	SEMA7A CD108 SEMAL	Homo sapiens (Human)	666	FUNCTION: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. {ECO:0000269|PubMed:12879062, ECO:0000269|PubMed:17377534, ECO:0000269|PubMed:17671519}.		axon extension [GO:0048675]; axon guidance [GO:0007411]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; olfactory lobe development [GO:0021988]; osteoblast differentiation [GO:0001649]; positive regulation of axon extension [GO:0045773]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of protein phosphorylation [GO:0001934]; regulation of inflammatory response [GO:0050727]; semaphorin-plexin signaling pathway [GO:0071526]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]	chemorepellent activity [GO:0045499]; integrin binding [GO:0005178]; semaphorin receptor binding [GO:0030215]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; chemorepellent activity [GO:0045499]; integrin binding [GO:0005178]; semaphorin receptor binding [GO:0030215]; axon extension [GO:0048675]; axon guidance [GO:0007411]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; olfactory lobe development [GO:0021988]; osteoblast differentiation [GO:0001649]; positive regulation of axon extension [GO:0045773]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of protein phosphorylation [GO:0001934]; regulation of inflammatory response [GO:0050727]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}; Extracellular side {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
O75330	reviewed	HMMR_HUMAN	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)	HMMR IHABP RHAMM	Homo sapiens (Human)	724	FUNCTION: Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). {ECO:0000250|UniProtKB:Q00547}.		hyaluronan catabolic process [GO:0030214]; receptor-mediated endocytosis [GO:0006898]	cell surface [GO:0009986]; centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; spindle [GO:0005819]	cargo receptor activity [GO:0038024]; hyaluronic acid binding [GO:0005540]	cell surface [GO:0009986]; centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; spindle [GO:0005819]; cargo receptor activity [GO:0038024]; hyaluronic acid binding [GO:0005540]; hyaluronan catabolic process [GO:0030214]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: Cell surface {ECO:0000250|UniProtKB:Q00547}. Cytoplasm {ECO:0000250|UniProtKB:Q00547}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q00547}.
O75334	reviewed	LIPA2_HUMAN	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2)	PPFIA2	Homo sapiens (Human)	1257	FUNCTION: Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165). {ECO:0000269|PubMed:30021165, ECO:0000269|PubMed:9624153}.		cell-matrix adhesion [GO:0007160]; dense core granule cytoskeletal transport [GO:0099519]; regulation of dendritic spine development [GO:0060998]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of synaptic vesicle exocytosis [GO:2000300]; synapse organization [GO:0050808]	axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; postsynaptic specialization [GO:0099572]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]	structural constituent of presynapse [GO:0099181]	axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; postsynaptic specialization [GO:0099572]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; structural constituent of presynapse [GO:0099181]; cell-matrix adhesion [GO:0007160]; dense core granule cytoskeletal transport [GO:0099519]; regulation of dendritic spine development [GO:0060998]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of synaptic vesicle exocytosis [GO:2000300]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9624153}. Cell surface {ECO:0000269|PubMed:9624153}. Cell projection, dendritic spine {ECO:0000269|PubMed:30021165}. Note=Colocalizes with PTPRF at the cell surface.
O75339	reviewed	CILP1_HUMAN	Cartilage intermediate layer protein 1 (CILP-1) (Cartilage intermediate-layer protein) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2]	CILP UNQ602/PRO1188	Homo sapiens (Human)	1184	FUNCTION: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. {ECO:0000269|PubMed:12746903, ECO:0000269|PubMed:15864306}.	MISCELLANEOUS: Antibodies against CILP are detected in patients with early-stage knee osteoarthritis and rheumatoid arthritis.	negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]		collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:15864306}.
O75340	reviewed	PDCD6_HUMAN	Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2)	PDCD6 ALG2	Homo sapiens (Human)	191	FUNCTION: Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779). {ECO:0000250|UniProtKB:P12815, ECO:0000269|PubMed:16132846, ECO:0000269|PubMed:19520058, ECO:0000269|PubMed:19864416, ECO:0000269|PubMed:20691033, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:25667979, ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27784779, ECO:0000269|PubMed:27813252}.; FUNCTION: [Isoform 2]: Has a lower Ca(2+) affinity than isoform 1 (By similarity). {ECO:0000250|UniProtKB:P12815}.		angiogenesis [GO:0001525]; apoptotic signaling pathway [GO:0097190]; cellular response to heat [GO:0034605]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]	COPII vesicle coat [GO:0030127]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; protein-membrane adaptor activity [GO:0043495]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	COPII vesicle coat [GO:0030127]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; protein-membrane adaptor activity [GO:0043495]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; angiogenesis [GO:0001525]; apoptotic signaling pathway [GO:0097190]; cellular response to heat [GO:0034605]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16957052, ECO:0000269|PubMed:27813252}; Peripheral membrane protein {ECO:0000269|PubMed:16957052}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:27716508}. Cytoplasm {ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27784779}. Nucleus {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:27784779}. Endosome {ECO:0000269|PubMed:19864416}. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus (PubMed:17045351). Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules (PubMed:21122810). In response to calcium increase, relocates from cytoplasm to COPII vesicle coat (PubMed:27716508). Localizes to endoplasmic reticulum exit site (ERES) (PubMed:27813252). {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27813252}.
O75342	reviewed	LX12B_HUMAN	Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12)	ALOX12B	Homo sapiens (Human)	701	FUNCTION: Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:9837935, PubMed:9618483, PubMed:21558561). In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (PubMed:21558561). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:21558561). May also play a role in the regulation of the expression of airway mucins (PubMed:22441738). {ECO:0000269|PubMed:21558561, ECO:0000269|PubMed:22441738, ECO:0000269|PubMed:9618483, ECO:0000269|PubMed:9837935}.		arachidonic acid metabolic process [GO:0019369]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid oxidation [GO:0034440]; lipoxygenase pathway [GO:0019372]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mucus secretion [GO:0070257]; protein lipidation [GO:0006497]; sphingolipid metabolic process [GO:0006665]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]	arachidonate 12(R)-lipoxygenase activity [GO:0106237]; arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 8(R)-lipoxygenase activity [GO:0047677]; iron ion binding [GO:0005506]; isomerase activity [GO:0016853]; linoleate 9S-lipoxygenase activity [GO:1990136]; lyase activity [GO:0016829]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; arachidonate 12(R)-lipoxygenase activity [GO:0106237]; arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 8(R)-lipoxygenase activity [GO:0047677]; iron ion binding [GO:0005506]; isomerase activity [GO:0016853]; linoleate 9S-lipoxygenase activity [GO:1990136]; lyase activity [GO:0016829]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; arachidonic acid metabolic process [GO:0019369]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid oxidation [GO:0034440]; lipoxygenase pathway [GO:0019372]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mucus secretion [GO:0070257]; protein lipidation [GO:0006497]; sphingolipid metabolic process [GO:0006665]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00726}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9837935}.
O75343	reviewed	GCYB2_HUMAN	Guanylate cyclase soluble subunit beta-2 (GCS-beta-2) (EC 4.6.1.2)	GUCY1B2	Homo sapiens (Human)	617		MISCELLANEOUS: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.	cGMP-mediated signaling [GO:0019934]; response to oxygen levels [GO:0070482]	cytosol [GO:0005829]; guanylate cyclase complex, soluble [GO:0008074]	GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; guanylate cyclase complex, soluble [GO:0008074]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; cGMP-mediated signaling [GO:0019934]; response to oxygen levels [GO:0070482]	SUBCELLULAR LOCATION: Cytoplasm.
O75344	reviewed	FKBP6_HUMAN	Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36)	FKBP6 FKBP36	Homo sapiens (Human)	327	FUNCTION: Has an essential role in spermatogenesis (PubMed:36150389). It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis (By similarity). May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). {ECO:0000250|UniProtKB:Q91XW8, ECO:0000269|PubMed:36150389}.		cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; regulatory ncRNA-mediated gene silencing [GO:0031047]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; synaptonemal complex [GO:0000795]	FK506 binding [GO:0005528]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; synaptonemal complex [GO:0000795]; FK506 binding [GO:0005528]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; regulatory ncRNA-mediated gene silencing [GO:0031047]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36150389}. Nucleus {ECO:0000269|PubMed:36150389}. Note=In spermatocytes, it colocalizes with PIWIL1 in large cytoplasmic granules (PubMed:36150389). Does not localize to the synaptonemal complex (PubMed:36150389). {ECO:0000269|PubMed:36150389}.
O75347	reviewed	TBCA_HUMAN	Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA)	TBCA	Homo sapiens (Human)	108	FUNCTION: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.		post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]	beta-tubulin binding [GO:0048487]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; beta-tubulin binding [GO:0048487]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; tubulin binding [GO:0015631]; post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
O75348	reviewed	VATG1_HUMAN	V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16)	ATP6V1G1 ATP6G ATP6G1 ATP6J	Homo sapiens (Human)	118	FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002, PubMed:32001091). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}.		cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:29993276}.
O75351	reviewed	VPS4B_HUMAN	Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1)	VPS4B SKD1 VPS42 MIG1	Homo sapiens (Human)	444	FUNCTION: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission (PubMed:18687924). Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:18687924, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:16193069, ECO:0000269|PubMed:18606141}.		angiogenesis [GO:0001525]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; canonical Wnt signaling pathway [GO:0060070]; cholesterol transport [GO:0030301]; endosomal transport [GO:0016197]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ESCRT III complex disassembly [GO:1904903]; establishment of blood-brain barrier [GO:0060856]; late endosomal microautophagy [GO:0061738]; late endosome to lysosome transport via multivesicular body sorting pathway [GO:0061764]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; negative regulation of exosomal secretion [GO:1903542]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of centriole elongation [GO:1903724]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; potassium ion transport [GO:0006813]; protein depolymerization [GO:0051261]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; response to lipid [GO:0033993]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuole organization [GO:0007033]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	ATPase complex [GO:1904949]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome membrane [GO:0031902]; midbody [GO:0030496]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	ATPase complex [GO:1904949]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome membrane [GO:0031902]; midbody [GO:0030496]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; angiogenesis [GO:0001525]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; canonical Wnt signaling pathway [GO:0060070]; cholesterol transport [GO:0030301]; endosomal transport [GO:0016197]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ESCRT III complex disassembly [GO:1904903]; establishment of blood-brain barrier [GO:0060856]; late endosomal microautophagy [GO:0061738]; late endosome to lysosome transport via multivesicular body sorting pathway [GO:0061764]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; negative regulation of exosomal secretion [GO:1903542]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of centriole elongation [GO:1903724]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; potassium ion transport [GO:0006813]; protein depolymerization [GO:0051261]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; response to lipid [GO:0033993]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuole organization [GO:0007033]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:P46467}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1 particles purified from acutely infected cells. {ECO:0000269|PubMed:14505570}.
O75354	reviewed	ENTP6_HUMAN	Ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase 6) (EC 3.6.1.6) (CD39 antigen-like 2)	ENTPD6 CD39L2 IL6ST2	Homo sapiens (Human)	484	FUNCTION: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PubMed:10948193, PubMed:14529283, PubMed:11041856). The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PubMed:10948193, PubMed:14529283, PubMed:11041856). {ECO:0000269|PubMed:10948193, ECO:0000269|PubMed:11041856, ECO:0000269|PubMed:14529283}.		nucleoside diphosphate catabolic process [GO:0009134]; response to calcium ion [GO:0051592]; response to magnesium ion [GO:0032026]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	CDP phosphatase activity [GO:0036384]; GDP phosphatase activity [GO:0004382]; guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity [GO:0008894]; IDP phosphatase activity [GO:1990003]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; CDP phosphatase activity [GO:0036384]; GDP phosphatase activity [GO:0004382]; guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity [GO:0008894]; IDP phosphatase activity [GO:1990003]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]; nucleoside diphosphate catabolic process [GO:0009134]; response to calcium ion [GO:0051592]; response to magnesium ion [GO:0032026]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ER31}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:10948193, ECO:0000269|PubMed:11041856}. Cell membrane {ECO:0000269|PubMed:10948193, ECO:0000269|PubMed:11041856}; Single-pass type II membrane protein {ECO:0000255}. Note=Exists as a secreted and membrane-bound forms in the medium of transfected cells, the secreted form is predominant. {ECO:0000269|PubMed:10948193, ECO:0000269|PubMed:11041856}.
O75355	reviewed	ENTP3_HUMAN	Ectonucleoside triphosphate diphosphohydrolase 3 (NTPDase 3) (EC 3.6.1.5) (CD39 antigen-like 3) (Ecto-ATP diphosphohydrolase 3) (Ecto-ATPDase 3) (Ecto-ATPase 3) (Ecto-apyrase 3) (HB6)	ENTPD3 CD39L3	Homo sapiens (Human)	529	FUNCTION: Has a threefold preference for the hydrolysis of ATP over ADP. {ECO:0000269|PubMed:10231536, ECO:0000269|PubMed:11300774}.		nucleoside diphosphate catabolic process [GO:0009134]; nucleoside triphosphate catabolic process [GO:0009143]	plasma membrane [GO:0005886]	ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]	plasma membrane [GO:0005886]; ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]; nucleoside diphosphate catabolic process [GO:0009134]; nucleoside triphosphate catabolic process [GO:0009143]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BFW6}; Multi-pass membrane protein {ECO:0000255}.
O75356	reviewed	ENTP5_HUMAN	Nucleoside diphosphate phosphatase ENTPD5 (EC 3.6.1.6) (CD39 antigen-like 4) (ER-UDPase) (Ectonucleoside triphosphate diphosphohydrolase 5) (NTPDase 5) (Guanosine-diphosphatase ENTPD5) (GDPase ENTPD5) (Inosine diphosphate phosphatase ENTPD5) (Nucleoside diphosphatase) (Uridine-diphosphatase ENTPD5) (UDPase ENTPD5)	ENTPD5 CD39L4 PCPH	Homo sapiens (Human)	428	FUNCTION: Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:15698960, PubMed:10400613). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity). {ECO:0000250|UniProtKB:Q9WUZ9, ECO:0000269|PubMed:10400613, ECO:0000269|PubMed:15698960}.	MISCELLANEOUS: May mediate some of the cancer-related phenotypes associated with AKT1 activation: its up-regulation by AKT1 leads to the elevation of aerobic glycolysis seen in tumor cells, a phenomenon known as the Warburg effect. {ECO:0000305|PubMed:21074248}.	'de novo' post-translational protein folding [GO:0051084]; nucleoside diphosphate catabolic process [GO:0009134]; protein N-linked glycosylation [GO:0006487]; UDP catabolic process [GO:0006256]; UDP-glucose metabolic process [GO:0006011]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]	ADP phosphatase activity [GO:0043262]; CDP phosphatase activity [GO:0036384]; GDP phosphatase activity [GO:0004382]; IDP phosphatase activity [GO:1990003]; UDP phosphatase activity [GO:0045134]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; ADP phosphatase activity [GO:0043262]; CDP phosphatase activity [GO:0036384]; GDP phosphatase activity [GO:0004382]; IDP phosphatase activity [GO:1990003]; UDP phosphatase activity [GO:0045134]; 'de novo' post-translational protein folding [GO:0051084]; nucleoside diphosphate catabolic process [GO:0009134]; protein N-linked glycosylation [GO:0006487]; UDP catabolic process [GO:0006256]; UDP-glucose metabolic process [GO:0006011]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9WUZ9}. Secreted {ECO:0000269|PubMed:10400613, ECO:0000269|PubMed:15698960}.
O75360	reviewed	PROP1_HUMAN	Homeobox protein prophet of Pit-1 (PROP-1) (Pituitary-specific homeodomain factor)	PROP1	Homo sapiens (Human)	226	FUNCTION: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.		apoptotic process [GO:0006915]; blood vessel development [GO:0001568]; cell migration [GO:0016477]; central nervous system development [GO:0007417]; dorsal/ventral pattern formation [GO:0009953]; hypophysis morphogenesis [GO:0048850]; hypothalamus cell differentiation [GO:0021979]; negative regulation of apoptotic process [GO:0043066]; regulation of transcription by RNA polymerase II [GO:0006357]; somatotropin secreting cell differentiation [GO:0060126]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; apoptotic process [GO:0006915]; blood vessel development [GO:0001568]; cell migration [GO:0016477]; central nervous system development [GO:0007417]; dorsal/ventral pattern formation [GO:0009953]; hypophysis morphogenesis [GO:0048850]; hypothalamus cell differentiation [GO:0021979]; negative regulation of apoptotic process [GO:0043066]; regulation of transcription by RNA polymerase II [GO:0006357]; somatotropin secreting cell differentiation [GO:0060126]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
O75362	reviewed	ZN217_HUMAN	Zinc finger protein 217	ZNF217 ZABC1	Homo sapiens (Human)	1048	FUNCTION: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	histone deacetylase complex [GO:0000118]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	histone deacetylase complex [GO:0000118]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O75364	reviewed	PITX3_HUMAN	Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3)	PITX3 PTX3	Homo sapiens (Human)	302	FUNCTION: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity). {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; cellular response to glial cell derived neurotrophic factor [GO:1990792]; dopaminergic neuron differentiation [GO:0071542]; lens development in camera-type eye [GO:0002088]; lens fiber cell differentiation [GO:0070306]; lens morphogenesis in camera-type eye [GO:0002089]; locomotory behavior [GO:0007626]; midbrain development [GO:0030901]; negative regulation of gliogenesis [GO:0014014]; neuron development [GO:0048666]; positive regulation of cell proliferation in midbrain [GO:1904935]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cocaine [GO:0042220]; response to immobilization stress [GO:0035902]; response to methamphetamine hydrochloride [GO:1904313]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; cellular response to glial cell derived neurotrophic factor [GO:1990792]; dopaminergic neuron differentiation [GO:0071542]; lens development in camera-type eye [GO:0002088]; lens fiber cell differentiation [GO:0070306]; lens morphogenesis in camera-type eye [GO:0002089]; locomotory behavior [GO:0007626]; midbrain development [GO:0030901]; negative regulation of gliogenesis [GO:0014014]; neuron development [GO:0048666]; positive regulation of cell proliferation in midbrain [GO:1904935]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cocaine [GO:0042220]; response to immobilization stress [GO:0035902]; response to methamphetamine hydrochloride [GO:1904313]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
O75365	reviewed	TP4A3_HUMAN	Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3)	PTP4A3 PRL3	Homo sapiens (Human)	173	FUNCTION: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. {ECO:0000269|PubMed:11355880, ECO:0000269|PubMed:12782572}.	MISCELLANEOUS: [Isoform 2]: Unstructured and inactive. {ECO:0000305}.	cellular response to leukemia inhibitory factor [GO:1990830]; dephosphorylation [GO:0016311]; endothelial cell migration [GO:0043542]; Notch signaling pathway [GO:0007219]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of vascular permeability [GO:0043117]; regulation of DNA-templated transcription [GO:0006355]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	prenylated protein tyrosine phosphatase activity [GO:0004727]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; prenylated protein tyrosine phosphatase activity [GO:0004727]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cellular response to leukemia inhibitory factor [GO:1990830]; dephosphorylation [GO:0016311]; endothelial cell migration [GO:0043542]; Notch signaling pathway [GO:0007219]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of vascular permeability [GO:0043117]; regulation of DNA-templated transcription [GO:0006355]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12782572}. Early endosome {ECO:0000269|PubMed:12782572}.
O75366	reviewed	AVIL_HUMAN	Advillin (p92)	AVIL	Homo sapiens (Human)	819	FUNCTION: Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling (PubMed:29058690). May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690}.		actin filament organization [GO:0007015]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cilium assembly [GO:0060271]; nervous system development [GO:0007399]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of diacylglycerol biosynthetic process [GO:1900480]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; axon [GO:0030424]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; axon [GO:0030424]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; actin filament organization [GO:0007015]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cilium assembly [GO:0060271]; nervous system development [GO:0007399]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of diacylglycerol biosynthetic process [GO:1900480]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:29058690}. Cell projection, lamellipodium {ECO:0000269|PubMed:29058690}. Cell junction, focal adhesion {ECO:0000269|PubMed:29058690}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9WU06}. Cell projection, axon {ECO:0000250|UniProtKB:Q9WU06}. Note=In podocytes, present in the F-actin-enriched cell periphery that generates lamellipodia and focal adhesions. {ECO:0000269|PubMed:29058690}.
O75367	reviewed	H2AY_HUMAN	Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)	MACROH2A1 H2AFY	Homo sapiens (Human)	369	FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (PubMed:15897469). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15897469). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708). {ECO:0000269|PubMed:12718888, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16107708, ECO:0000269|PubMed:16428466}.; FUNCTION: [Isoform 1]: Isoform that specifically binds poly-ADP-ribose and O-acetyl-ADP-ribose and plays a key role in NAD(+) metabolism (PubMed:15902274). Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them (By similarity). This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration (By similarity). Increases the expression of genes involved in redox metabolism, including SOD3 (PubMed:23022728). {ECO:0000250|UniProtKB:Q9QZQ8, ECO:0000269|PubMed:15902274, ECO:0000269|PubMed:23022728}.; FUNCTION: [Isoform 2]: In contrast to isoform 1, does not bind poly-ADP-ribose (PubMed:15902274). Represses SOD3 gene expression (PubMed:23022728). {ECO:0000269|PubMed:15902274, ECO:0000269|PubMed:23022728}.	MISCELLANEOUS: [Isoform 2]: The preferential expression of isoform 2 over that of isoform 1 requires the presence of DDX5/DDX17. {ECO:0000269|PubMed:23022728}.; MISCELLANEOUS: [Isoform 1]: Preferentially expressed over isoform 2 in the absence of DDX5/DDX17. {ECO:0000269|PubMed:23022728}.	DNA repair [GO:0006281]; dosage compensation [GO:0007549]; epigenetic regulation of gene expression [GO:0040029]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of cell cycle G2/M phase transition [GO:1902750]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of protein localization to chromosome, telomeric region [GO:1904815]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of response to oxidative stress [GO:1902883]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; nucleosome assembly [GO:0006334]; positive regulation of endodermal cell differentiation [GO:1903226]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of response to oxidative stress [GO:1902884]; regulation of lipid metabolic process [GO:0019216]; regulation of NAD metabolic process [GO:1902688]; regulation of oxidative phosphorylation [GO:0002082]; regulation of response to oxidative stress [GO:1902882]; transcription initiation-coupled chromatin remodeling [GO:0045815]	Barr body [GO:0001740]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; sex chromatin [GO:0001739]; site of DNA damage [GO:0090734]	ADP-D-ribose binding [GO:0072570]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; double-stranded methylated DNA binding [GO:0010385]; enzyme binding [GO:0019899]; nucleosomal DNA binding [GO:0031492]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; rDNA binding [GO:0000182]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; structural constituent of chromatin [GO:0030527]; transcription cis-regulatory region binding [GO:0000976]	Barr body [GO:0001740]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; sex chromatin [GO:0001739]; site of DNA damage [GO:0090734]; ADP-D-ribose binding [GO:0072570]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; double-stranded methylated DNA binding [GO:0010385]; enzyme binding [GO:0019899]; nucleosomal DNA binding [GO:0031492]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; rDNA binding [GO:0000182]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; structural constituent of chromatin [GO:0030527]; transcription cis-regulatory region binding [GO:0000976]; DNA repair [GO:0006281]; dosage compensation [GO:0007549]; epigenetic regulation of gene expression [GO:0040029]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of cell cycle G2/M phase transition [GO:1902750]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of protein localization to chromosome, telomeric region [GO:1904815]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of response to oxidative stress [GO:1902883]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; nucleosome assembly [GO:0006334]; positive regulation of endodermal cell differentiation [GO:1903226]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of response to oxidative stress [GO:1902884]; regulation of lipid metabolic process [GO:0019216]; regulation of NAD metabolic process [GO:1902688]; regulation of oxidative phosphorylation [GO:0002082]; regulation of response to oxidative stress [GO:1902882]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:9634239}. Chromosome {ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:29905837, ECO:0000269|PubMed:9634239}. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin (PubMed:15621527, PubMed:15897469, PubMed:9634239). Recruited to DNA damage sites in an APLF-dependent manner (PubMed:21211722, PubMed:29905837). {ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:29905837, ECO:0000269|PubMed:9634239}.
O75368	reviewed	SH3L1_HUMAN	Adapter SH3BGRL (SH3 domain-binding glutamic acid-rich-like protein 1)	SH3BGRL	Homo sapiens (Human)	114	FUNCTION: Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs (PubMed:34331014). May function as a ubiquitin ligase-substrate adapter (PubMed:34331014, PubMed:34870550). Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs (PubMed:34331014, PubMed:34870550). {ECO:0000269|PubMed:34331014, ECO:0000269|PubMed:34870550}.		positive regulation of cytoplasmic translational initiation [GO:1904690]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	protein-RNA adaptor activity [GO:0140517]; SH3 domain binding [GO:0017124]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-RNA adaptor activity [GO:0140517]; SH3 domain binding [GO:0017124]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; positive regulation of cytoplasmic translational initiation [GO:1904690]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:34870550, ECO:0000305|PubMed:34331014}. Cell membrane {ECO:0000269|PubMed:32381043}.
O75369	reviewed	FLNB_HUMAN	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	FLNB FLN1L FLN3 TABP TAP	Homo sapiens (Human)	2602	FUNCTION: Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.	MISCELLANEOUS: [Isoform 2]: May be due to exon skipping. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to exon skipping. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be due to competing donor splice sites. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: May be due to exon skipping. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; cellular response to type II interferon [GO:0071346]; epithelial cell morphogenesis [GO:0003382]; keratinocyte development [GO:0003334]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519]	actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]	actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; actin cytoskeleton organization [GO:0030036]; cellular response to type II interferon [GO:0071346]; epithelial cell morphogenesis [GO:0003382]; keratinocyte development [GO:0003334]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, myofibril, sarcomere, Z line. Note=In differentiating myotubes, isoform 1, isoform 2 and isoform 3 are localized diffusely throughout the cytoplasm with regions of enrichment at the longitudinal actin stress fiber. In differentiated tubes, isoform 1 is also detected within the Z-lines.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton, stress fiber.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytoskeleton, stress fiber.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm, cytoskeleton. Note=Polarized at the periphery of myotubes.
O75376	reviewed	NCOR1_HUMAN	Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)	NCOR1 KIAA1047	Homo sapiens (Human)	2440	FUNCTION: Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.		chromatin organization [GO:0006325]; locomotor rhythm [GO:0045475]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glycolytic process [GO:0045820]; negative regulation of JNK cascade [GO:0046329]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; spindle assembly [GO:0051225]	chromatin [GO:0000785]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	histone deacetylase binding [GO:0042826]; nuclear receptor binding [GO:0016922]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; histone deacetylase binding [GO:0042826]; nuclear receptor binding [GO:0016922]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]; chromatin organization [GO:0006325]; locomotor rhythm [GO:0045475]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glycolytic process [GO:0045820]; negative regulation of JNK cascade [GO:0046329]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
O75379	reviewed	VAMP4_HUMAN	Vesicle-associated membrane protein 4 (VAMP-4)	VAMP4	Homo sapiens (Human)	141	FUNCTION: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.		endocytic recycling [GO:0032456]; Golgi ribbon formation [GO:0090161]; regulation of synaptic vesicle endocytosis [GO:1900242]; SNARE complex assembly [GO:0035493]; synaptic vesicle to endosome fusion [GO:0016189]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]		cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; endocytic recycling [GO:0032456]; Golgi ribbon formation [GO:0090161]; regulation of synaptic vesicle endocytosis [GO:1900242]; SNARE complex assembly [GO:0035493]; synaptic vesicle to endosome fusion [GO:0016189]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.
O75381	reviewed	PEX14_HUMAN	Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14)	PEX14	Homo sapiens (Human)	377	FUNCTION: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:9653144, PubMed:24235149, PubMed:28765278). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}.		cellular response to reactive oxygen species [GO:0034614]; microtubule anchoring [GO:0034453]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein binding [GO:0032091]; peroxisome organization [GO:0007031]; peroxisome transport along microtubule [GO:0036250]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein-containing complex assembly [GO:0065003]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	beta-tubulin binding [GO:0048487]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein transmembrane transporter activity [GO:0008320]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; beta-tubulin binding [GO:0048487]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein transmembrane transporter activity [GO:0008320]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714]; cellular response to reactive oxygen species [GO:0034614]; microtubule anchoring [GO:0034453]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein binding [GO:0032091]; peroxisome organization [GO:0007031]; peroxisome transport along microtubule [GO:0036250]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:19197237}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q642G4}.
O75382	reviewed	TRIM3_HUMAN	Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)	TRIM3 BERP RNF22 RNF97	Homo sapiens (Human)	744	FUNCTION: E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A (PubMed:24393003). Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999). {ECO:0000250|UniProtKB:Q9R1R2, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:24393003, ECO:0000269|PubMed:32878999}.		negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]	identical protein binding [GO:0042802]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; identical protein binding [GO:0042802]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36481767}. Early endosome {ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:32878999}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:32878999}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9R1R2}. Note=Mainly located in the Golgi apparatus and transported to the early endosomes upon stimulation with dsRNA. {ECO:0000269|PubMed:32878999}.
O75385	reviewed	ULK1_HUMAN	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)	ULK1 KIAA0722	Homo sapiens (Human)	1050	FUNCTION: Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:31123703, PubMed:29487085). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; axon extension [GO:0048675]; cellular response to nutrient levels [GO:0031669]; late nucleophagy [GO:0044805]; macroautophagy [GO:0016236]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of protein-containing complex assembly [GO:0031333]; neuron projection development [GO:0031175]; neuron projection regeneration [GO:0031102]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; protein autophosphorylation [GO:0046777]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of macroautophagy [GO:0016241]; regulation of protein lipidation [GO:1903059]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	Atg1/ULK1 kinase complex [GO:1990316]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; omegasome membrane [GO:1903349]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome [GO:0055037]	ATP binding [GO:0005524]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]	Atg1/ULK1 kinase complex [GO:1990316]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; omegasome membrane [GO:1903349]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome [GO:0055037]; ATP binding [GO:0005524]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; axon extension [GO:0048675]; cellular response to nutrient levels [GO:0031669]; late nucleophagy [GO:0044805]; macroautophagy [GO:0016236]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of protein-containing complex assembly [GO:0031333]; neuron projection development [GO:0031175]; neuron projection regeneration [GO:0031102]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; protein autophosphorylation [GO:0046777]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of macroautophagy [GO:0016241]; regulation of protein lipidation [GO:1903059]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}.
O75386	reviewed	TULP3_HUMAN	Tubby-related protein 3 (Tubby-like protein 3)	TULP3 TUBL3	Homo sapiens (Human)	442	FUNCTION: Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes. {ECO:0000269|PubMed:11375483, ECO:0000269|PubMed:20889716, ECO:0000269|PubMed:31761534}.		anterior/posterior pattern specification [GO:0009952]; bone development [GO:0060348]; brain development [GO:0007420]; bronchus morphogenesis [GO:0060434]; central nervous system neuron differentiation [GO:0021953]; embryonic camera-type eye development [GO:0031076]; embryonic digit morphogenesis [GO:0042733]; embryonic neurocranium morphogenesis [GO:0048702]; G protein-coupled receptor signaling pathway [GO:0007186]; ganglion development [GO:0061548]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021914]; neural tube closure [GO:0001843]; protein localization to cilium [GO:0061512]; regulation of DNA-templated transcription [GO:0006355]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]	9+0 non-motile cilium [GO:0097731]; axoneme [GO:0005930]; ciliary base [GO:0097546]; cilium [GO:0005929]; extracellular region [GO:0005576]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; intraciliary transport particle A binding [GO:0120160]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-containing complex binding [GO:0044877]	9+0 non-motile cilium [GO:0097731]; axoneme [GO:0005930]; ciliary base [GO:0097546]; cilium [GO:0005929]; extracellular region [GO:0005576]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; intraciliary transport particle A binding [GO:0120160]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-containing complex binding [GO:0044877]; anterior/posterior pattern specification [GO:0009952]; bone development [GO:0060348]; brain development [GO:0007420]; bronchus morphogenesis [GO:0060434]; central nervous system neuron differentiation [GO:0021953]; embryonic camera-type eye development [GO:0031076]; embryonic digit morphogenesis [GO:0042733]; embryonic neurocranium morphogenesis [GO:0048702]; G protein-coupled receptor signaling pathway [GO:0007186]; ganglion development [GO:0061548]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021914]; neural tube closure [GO:0001843]; protein localization to cilium [GO:0061512]; regulation of DNA-templated transcription [GO:0006355]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]	SUBCELLULAR LOCATION: Nucleus. Cell membrane. Cell projection, cilium {ECO:0000269|PubMed:27932497, ECO:0000269|PubMed:35397207}. Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. {ECO:0000250}.
O75387	reviewed	LAT3_HUMAN	Large neutral amino acids transporter small subunit 3 (L-type amino acid transporter 3) (Prostate cancer overexpressed gene 1 protein) (Solute carrier family 43 member 1)	SLC43A1 LAT3 PB39 POV1	Homo sapiens (Human)	559	FUNCTION: Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine (PubMed:12930836). The transport activity is sodium ions-independent, electroneutral and mediated by a facilitated diffusion (PubMed:12930836). {ECO:0000269|PubMed:12930836}.		amino acid transport [GO:0006865]; isoleucine transport [GO:0015818]; L-valine transmembrane transport [GO:1903785]; leucine transport [GO:0015820]; negative regulation of amino acid transport [GO:0051956]; negative regulation of leucine import [GO:0060358]; neutral amino acid transport [GO:0015804]	apical plasma membrane [GO:0016324]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; podocyte foot [GO:0098846]	amino acid transmembrane transporter activity [GO:0015171]; L-amino acid transmembrane transporter activity [GO:0015179]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-leucine transmembrane transporter activity [GO:0015190]; L-valine transmembrane transporter activity [GO:0005304]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	apical plasma membrane [GO:0016324]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; podocyte foot [GO:0098846]; amino acid transmembrane transporter activity [GO:0015171]; L-amino acid transmembrane transporter activity [GO:0015179]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-leucine transmembrane transporter activity [GO:0015190]; L-valine transmembrane transporter activity [GO:0005304]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; amino acid transport [GO:0006865]; isoleucine transport [GO:0015818]; L-valine transmembrane transport [GO:1903785]; leucine transport [GO:0015820]; negative regulation of amino acid transport [GO:0051956]; negative regulation of leucine import [GO:0060358]; neutral amino acid transport [GO:0015804]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BSM7}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19443642}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BSM7}; Multi-pass membrane protein {ECO:0000255}. Note=Located in the apical plasma membrane of the podocyte foot processes (PubMed:19443642). Located in the plasma membrane of liver and skeletal muscle, and in the endoplasmic reticulum and in crystalline inclusions in pancreatic acinar cells (By similarity). {ECO:0000250|UniProtKB:Q8BSM7, ECO:0000269|PubMed:19443642}.
O75390	reviewed	CISY_HUMAN	Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase)	CS	Homo sapiens (Human)	466		MISCELLANEOUS: Citrate synthase is found in nearly all cells capable of oxidative metabolism.	carbohydrate metabolic process [GO:0005975]; citrate metabolic process [GO:0006101]; tricarboxylic acid cycle [GO:0006099]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	citrate (Si)-synthase activity [GO:0004108]; RNA binding [GO:0003723]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; citrate (Si)-synthase activity [GO:0004108]; RNA binding [GO:0003723]; carbohydrate metabolic process [GO:0005975]; citrate metabolic process [GO:0006101]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion matrix.
O75396	reviewed	SC22B_HUMAN	Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)	SEC22B SEC22L1	Homo sapiens (Human)	215	FUNCTION: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of autophagosome assembly [GO:1902902]; positive regulation of protein catabolic process [GO:0045732]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle fusion with Golgi apparatus [GO:0048280]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; melanosome [GO:0042470]; phagocytic vesicle membrane [GO:0030670]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133]	SNAP receptor activity [GO:0005484]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; melanosome [GO:0042470]; phagocytic vesicle membrane [GO:0030670]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133]; SNAP receptor activity [GO:0005484]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of autophagosome assembly [GO:1902902]; positive regulation of protein catabolic process [GO:0045732]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle fusion with Golgi apparatus [GO:0048280]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q4KM74}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q4KM74}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q4KM74}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q4KM74}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q4KM74}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000250|UniProtKB:Q4KM74, ECO:0000269|PubMed:17081065}.
O75398	reviewed	DEAF1_HUMAN	Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5)	DEAF1 SPN ZMYND5	Homo sapiens (Human)	565	FUNCTION: Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. {ECO:0000269|PubMed:10521432, ECO:0000269|PubMed:11427895, ECO:0000269|PubMed:11705868, ECO:0000269|PubMed:18826651, ECO:0000269|PubMed:19668219, ECO:0000269|PubMed:24726472}.	MISCELLANEOUS: Defective DEAF1 could confer a growth advantage to the mutated cells influencing the development and progression of neoplasia, e.g. in the case of colorectal carcinomas. Subcellular location in colorectal carcinomas (cytoplasmic or nuclear) is a prognostic factor that identifies a subgroup of patients with reduced survival. In addition, changes in the subcellular location correlates with the proliferative status of the cells.; MISCELLANEOUS: [Isoform 3]: Has no predictable signal peptide. {ECO:0000305}.	anatomical structure morphogenesis [GO:0009653]; embryonic skeletal system development [GO:0048706]; germ cell development [GO:0007281]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; anatomical structure morphogenesis [GO:0009653]; embryonic skeletal system development [GO:0048706]; germ cell development [GO:0007281]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Cytoplasm. Note=Cytoplasmic in non-mucinous colorectal carcinoma. When expressed alone, localized almost exclusively in the nucleus but, when expressed with isoform 4, nuclear expression decreases to 32% and cytoplasmic expression increases by 270%.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted. Note=Secreted in some cell types.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted. Note=Secreted in some cell types.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus. Note=When expressed alone, localizes mainly in the cytoplasm but, when expressed with isoform 1, nuclear localization is enhanced.
O75400	reviewed	PR40A_HUMAN	Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6)	PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225	Homo sapiens (Human)	957	FUNCTION: Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}.	MISCELLANEOUS: [Isoform 5]: Probable target of nonsense-mediated mRNA decay. {ECO:0000305}.	cell cycle [GO:0007049]; cell division [GO:0051301]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; regulation of cell shape [GO:0008360]; regulation of cytokinesis [GO:0032465]	membrane [GO:0016020]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]	RNA binding [GO:0003723]	membrane [GO:0016020]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]; RNA binding [GO:0003723]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; regulation of cell shape [GO:0008360]; regulation of cytokinesis [GO:0032465]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Nucleus matrix {ECO:0000269|PubMed:16391387}. Note=Colocalizes with AKAP8L in the nuclear matrix. {ECO:0000250}.
O75409	reviewed	HYPM_HUMAN	Huntingtin-interacting protein M (Histone H2A.P) (Huntingtin yeast partner M)	H2AP CXorf27 HYPM	Homo sapiens (Human)	117					DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]	
O75410	reviewed	TACC1_HUMAN	Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1)	TACC1 KIAA1103	Homo sapiens (Human)	805	FUNCTION: Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}.		cell division [GO:0051301]; cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]	nuclear estrogen receptor binding [GO:0030331]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; peroxisome proliferator activated receptor binding [GO:0042975]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; nuclear estrogen receptor binding [GO:0030331]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; peroxisome proliferator activated receptor binding [GO:0042975]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14767476}. Nucleus {ECO:0000269|PubMed:14767476}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21531210}. Midbody {ECO:0000269|PubMed:21531210}. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. {ECO:0000269|PubMed:21531210}.; SUBCELLULAR LOCATION: [Isoform 5]: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 10]: Cytoplasm {ECO:0000269|PubMed:20078863}.
O75414	reviewed	NDK6_HUMAN	Nucleoside diphosphate kinase 6 (NDK 6) (NDP kinase 6) (EC 2.7.4.6) (Inhibitor of p53-induced apoptosis-alpha) (IPIA-alpha) (nm23-H6)	NME6	Homo sapiens (Human)	186	FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.		apoptotic process [GO:0006915]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; negative regulation of cell growth [GO:0030308]; negative regulation of mitotic nuclear division [GO:0045839]; phosphorylation [GO:0016310]; UTP biosynthetic process [GO:0006228]	mitochondrion [GO:0005739]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]	mitochondrion [GO:0005739]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]; apoptotic process [GO:0006915]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; negative regulation of cell growth [GO:0030308]; negative regulation of mitotic nuclear division [GO:0045839]; phosphorylation [GO:0016310]; UTP biosynthetic process [GO:0006228]	
O75417	reviewed	DPOLQ_HUMAN	DNA polymerase theta (EC 2.7.7.7) (DNA polymerase eta)	POLQ POLH	Homo sapiens (Human)	2590	FUNCTION: DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963, PubMed:25643323). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323). POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963). POLQ-mediated MMEJ may be required to promote the survival of cells with a compromised HR repair pathway, thereby preventing genomic havoc by resolving unrepaired lesions (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs. It then extends each strand from the base-paired region using the opposing overhang as a template. Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323). The polymerase activity is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). Also exhibits low-fidelity DNA synthesis, translesion synthesis and lyase activity, and it is implicated in interstrand-cross-link repair, base excision repair and DNA end-joining (PubMed:14576298, PubMed:18503084, PubMed:19188258, PubMed:24648516). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). {ECO:0000250|UniProtKB:Q8CGS6, ECO:0000269|PubMed:14576298, ECO:0000269|PubMed:18503084, ECO:0000269|PubMed:19188258, ECO:0000269|PubMed:21050863, ECO:0000269|PubMed:22135286, ECO:0000269|PubMed:24648516, ECO:0000269|PubMed:25642963, ECO:0000269|PubMed:25643323}.		base-excision repair [GO:0006284]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein homooligomerization [GO:0051260]; somatic hypermutation of immunoglobulin genes [GO:0016446]	chromosome [GO:0005694]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; identical protein binding [GO:0042802]; single-stranded DNA helicase activity [GO:0017116]	chromosome [GO:0005694]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; identical protein binding [GO:0042802]; single-stranded DNA helicase activity [GO:0017116]; base-excision repair [GO:0006284]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein homooligomerization [GO:0051260]; somatic hypermutation of immunoglobulin genes [GO:0016446]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O18475}. Chromosome {ECO:0000269|PubMed:25642963}. Note=Enriched in chromatin in response to ultaviolet (UV) light (PubMed:25642963). Binds to chromatin during early G1 (PubMed:24989122). {ECO:0000269|PubMed:24989122, ECO:0000269|PubMed:25642963}.
O75419	reviewed	CDC45_HUMAN	Cell division control protein 45 homolog (PORC-PI-1)	CDC45 CDC45L CDC45L2 UNQ374/PRO710	Homo sapiens (Human)	566	FUNCTION: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}.		DNA replication checkpoint signaling [GO:0000076]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication preinitiation complex assembly [GO:1902977]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; CMG complex [GO:0071162]; DNA replication preinitiation complex [GO:0031261]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA replication origin binding [GO:0003688]; single-stranded DNA binding [GO:0003697]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; CMG complex [GO:0071162]; DNA replication preinitiation complex [GO:0031261]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA replication origin binding [GO:0003688]; single-stranded DNA binding [GO:0003697]; DNA replication checkpoint signaling [GO:0000076]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication preinitiation complex assembly [GO:1902977]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associates with chromatin. {ECO:0000305|PubMed:35585232}.
O75420	reviewed	GGYF1_HUMAN	GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1)	GIGYF1 CDS2 PERQ1 PP3360	Homo sapiens (Human)	1035	FUNCTION: May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.		insulin-like growth factor receptor signaling pathway [GO:0048009]	cytosol [GO:0005829]; protein-containing complex [GO:0032991]		cytosol [GO:0005829]; protein-containing complex [GO:0032991]; insulin-like growth factor receptor signaling pathway [GO:0048009]	
O75425	reviewed	MSPD3_HUMAN	Motile sperm domain-containing protein 3	MOSPD3	Homo sapiens (Human)	235			heart development [GO:0007507]	cytoplasm [GO:0005737]; membrane [GO:0016020]		cytoplasm [GO:0005737]; membrane [GO:0016020]; heart development [GO:0007507]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O75427	reviewed	LRCH4_HUMAN	Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein)	LRCH4 LRN LRRN1 LRRN4	Homo sapiens (Human)	683	FUNCTION: Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}.		membrane raft assembly [GO:0001765]; nervous system development [GO:0007399]; positive regulation of toll-like receptor signaling pathway [GO:0034123]	plasma membrane [GO:0005886]; PML body [GO:0016605]		plasma membrane [GO:0005886]; PML body [GO:0016605]; membrane raft assembly [GO:0001765]; nervous system development [GO:0007399]; positive regulation of toll-like receptor signaling pathway [GO:0034123]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q921G6}; Single-pass membrane protein {ECO:0000255}.
O75431	reviewed	MTX2_HUMAN	Metaxin-2 (Mitochondrial outer membrane import complex protein 2)	MTX2	Homo sapiens (Human)	263	FUNCTION: Involved in transport of proteins into the mitochondrion. {ECO:0000269|PubMed:10381257}.		inner mitochondrial membrane organization [GO:0007007]; mitochondrial transport [GO:0006839]; mitochondrion organization [GO:0007005]; protein insertion into mitochondrial outer membrane [GO:0045040]	cytoplasm [GO:0005737]; MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; SAM complex [GO:0001401]		cytoplasm [GO:0005737]; MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; SAM complex [GO:0001401]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial transport [GO:0006839]; mitochondrion organization [GO:0007005]; protein insertion into mitochondrial outer membrane [GO:0045040]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:10381257}. Mitochondrion {ECO:0000269|PubMed:25997101}.
O75436	reviewed	VP26A_HUMAN	Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26)	VPS26A VPS26	Homo sapiens (Human)	327	FUNCTION: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO:0000250|UniProtKB:P40336, ECO:0000269|PubMed:15078902, ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:22279231, ECO:0000303|PubMed:20923837, ECO:0000303|PubMed:21602791, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:23563491, ECO:0000305}.		endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosome [GO:0005764]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422]; vesicle [GO:0031982]		cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosome [GO:0005764]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422]; vesicle [GO:0031982]; endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15078903}. Endosome membrane {ECO:0000269|PubMed:22431521}; Peripheral membrane protein {ECO:0000250|UniProtKB:P40336}. Early endosome {ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:16190980, ECO:0000269|PubMed:16732284, ECO:0000269|PubMed:20682791}. Note=Localizes to tubular profiles adjacent to endosomes (PubMed:15078903). Predominantly found in early not late endosomes (By similarity). {ECO:0000250|UniProtKB:P40336}.
O75438	reviewed	NDUB1_HUMAN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (Complex I-MNLL) (CI-MNLL) (NADH-ubiquinone oxidoreductase MNLL subunit)	NDUFB1	Homo sapiens (Human)	58	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
O75439	reviewed	MPPB_HUMAN	Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52)	PMPCB MPPB	Homo sapiens (Human)	489	FUNCTION: Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (PubMed:29576218) (Probable). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (PubMed:22354088). {ECO:0000250|UniProtKB:Q03346, ECO:0000269|PubMed:22354088, ECO:0000269|PubMed:29576218, ECO:0000305|PubMed:22354088}.		mitochondrial calcium ion transmembrane transport [GO:0006851]; protein processing involved in protein targeting to mitochondrion [GO:0006627]	mitochondrial inner membrane [GO:0005743]; mitochondrial processing peptidase complex [GO:0017087]; mitochondrion [GO:0005739]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	mitochondrial inner membrane [GO:0005743]; mitochondrial processing peptidase complex [GO:0017087]; mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; mitochondrial calcium ion transmembrane transport [GO:0006851]; protein processing involved in protein targeting to mitochondrion [GO:0006627]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:22354088}.
O75443	reviewed	TECTA_HUMAN	Alpha-tectorin	TECTA	Homo sapiens (Human)	2155	FUNCTION: One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. {ECO:0000250}.		auditory receptor cell stereocilium organization [GO:0060088]; cell-matrix adhesion [GO:0007160]; sensory perception of sound [GO:0007605]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	extracellular matrix structural constituent [GO:0005201]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; extracellular matrix structural constituent [GO:0005201]; auditory receptor cell stereocilium organization [GO:0060088]; cell-matrix adhesion [GO:0007160]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}; Extracellular side {ECO:0000305}. Secreted, extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane. {ECO:0000250}.
O75444	reviewed	MAF_HUMAN	Transcription factor Maf (Proto-oncogene c-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog)	MAF	Homo sapiens (Human)	373	FUNCTION: Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. {ECO:0000250, ECO:0000269|PubMed:12149651, ECO:0000269|PubMed:14998494, ECO:0000269|PubMed:15007382, ECO:0000269|PubMed:16247450, ECO:0000269|PubMed:19143053}.		inner ear development [GO:0048839]; integrated stress response signaling [GO:0140467]; lens fiber cell differentiation [GO:0070306]; megakaryocyte differentiation [GO:0030219]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; regulation of chondrocyte differentiation [GO:0032330]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; inner ear development [GO:0048839]; integrated stress response signaling [GO:0140467]; lens fiber cell differentiation [GO:0070306]; megakaryocyte differentiation [GO:0030219]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; regulation of chondrocyte differentiation [GO:0032330]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
O75445	reviewed	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	USH2A	Homo sapiens (Human)	5202	FUNCTION: Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. {ECO:0000250|UniProtKB:Q2QI47}.		establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]; collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, stereocilium membrane {ECO:0000269|PubMed:14676276}; Single-pass type I membrane protein {ECO:0000269|PubMed:14676276}. Note=Component of the interstereocilia ankle links in the inner ear sensory cells. In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex. {ECO:0000250|UniProtKB:Q2QI47}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
O75446	reviewed	SAP30_HUMAN	Histone deacetylase complex subunit SAP30 (30 kDa Sin3-associated polypeptide) (Sin3 corepressor complex subunit SAP30) (Sin3-associated polypeptide p30)	SAP30	Homo sapiens (Human)	220	FUNCTION: Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. {ECO:0000250|UniProtKB:O88574, ECO:0000269|PubMed:9651585}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269|PubMed:21221920}.		modulation by host of symbiont transcription [GO:0052472]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of DNA-templated transcription [GO:0006355]; skeletal muscle cell differentiation [GO:0035914]	histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]	histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; modulation by host of symbiont transcription [GO:0052472]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of DNA-templated transcription [GO:0006355]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus.
O75448	reviewed	MED24_HUMAN	Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)	MED24 ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100	Homo sapiens (Human)	989	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:16595664}.		positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O75449	reviewed	KTNA1_HUMAN	Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin)	KATNA1	Homo sapiens (Human)	491	FUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; katanin complex [GO:0008352]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; spindle [GO:0005819]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568]; protein heterodimerization activity [GO:0046982]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; katanin complex [GO:0008352]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; spindle [GO:0005819]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568]; protein heterodimerization activity [GO:0046982]; cell cycle [GO:0007049]; cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:26929214, ECO:0000269|PubMed:9658175}. Midbody {ECO:0000269|PubMed:19261606}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:26929214, ECO:0000269|PubMed:9658175}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26929214}. Note=Predominantly cytoplasmic (PubMed:9658175). Localized diffusely in the cytoplasm during the interphase (PubMed:10751153). During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase and telophase is localized at the midbody region (PubMed:19261606). Also localized to the interphase centrosome and the mitotic spindle poles (By similarity). Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1 (PubMed:10751153). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214). {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:19261606, ECO:0000269|PubMed:26929214, ECO:0000269|PubMed:9658175}.
O75452	reviewed	RDH16_HUMAN	Retinol dehydrogenase 16 (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (Human epidermal retinol dehydrogenase) (hRDH-E) (Microsomal NAD(+)-dependent retinol dehydrogenase 4) (RoDH-4) (Short chain dehydrogenase/reductase family 9C member 8) (Sterol/retinol dehydrogenase)	RDH16 RODH4 SDR9C8	Homo sapiens (Human)	317	FUNCTION: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:9677409, PubMed:29541409). {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:12534290, ECO:0000269|PubMed:29541409, ECO:0000269|PubMed:9677409}.		lipid metabolic process [GO:0006629]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	11-cis-retinol dehydrogenase [GO:0106429]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802]; NAD-retinol dehydrogenase activity [GO:0004745]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; 11-cis-retinol dehydrogenase [GO:0106429]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802]; NAD-retinol dehydrogenase activity [GO:0004745]; lipid metabolic process [GO:0006629]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:9677409}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O54909}; Single-pass membrane protein {ECO:0000305}.
O75460	reviewed	ERN1_HUMAN	Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]	ERN1 IRE1	Homo sapiens (Human)	977	FUNCTION: Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:21317875, PubMed:28128204, PubMed:9637683, PubMed:30118681). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). {ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:21317875, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28128204, ECO:0000269|PubMed:30118681, ECO:0000269|PubMed:9637683, ECO:0000305|PubMed:24508390}.		cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to unfolded protein [GO:0034620]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial cell proliferation [GO:0001935]; insulin metabolic process [GO:1901142]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; mRNA catabolic process [GO:0006402]; mRNA splicing, via endonucleolytic cleavage and ligation [GO:0070054]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine trans-autophosphorylation [GO:1990579]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of RNA splicing [GO:0033120]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of macroautophagy [GO:0016241]; response to endoplasmic reticulum stress [GO:0034976]	AIP1-IRE1 complex [GO:1990597]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Ire1 complex [GO:1990332]; IRE1-RACK1-PP2A complex [GO:1990630]; IRE1-TRAF2-ASK1 complex [GO:1990604]; mitochondrion [GO:0005739]; nuclear inner membrane [GO:0005637]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA endonuclease activity [GO:0004521]; unfolded protein binding [GO:0051082]	AIP1-IRE1 complex [GO:1990597]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Ire1 complex [GO:1990332]; IRE1-RACK1-PP2A complex [GO:1990630]; IRE1-TRAF2-ASK1 complex [GO:1990604]; mitochondrion [GO:0005739]; nuclear inner membrane [GO:0005637]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA endonuclease activity [GO:0004521]; unfolded protein binding [GO:0051082]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to unfolded protein [GO:0034620]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial cell proliferation [GO:0001935]; insulin metabolic process [GO:1901142]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; mRNA catabolic process [GO:0006402]; mRNA splicing, via endonucleolytic cleavage and ligation [GO:0070054]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine trans-autophosphorylation [GO:1990579]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of RNA splicing [GO:0033120]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of macroautophagy [GO:0016241]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9637683}; Single-pass type I membrane protein {ECO:0000269|PubMed:9637683}.
O75461	reviewed	E2F6_HUMAN	Transcription factor E2F6 (E2F-6)	E2F6	Homo sapiens (Human)	281	FUNCTION: Inhibitor of E2F-dependent transcription (PubMed:9689056, PubMed:9704927, PubMed:9501179). Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:9501179). Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9501179). E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9704927, PubMed:9501179). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (PubMed:9689056, PubMed:9501179). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (PubMed:9501179). {ECO:0000250|UniProtKB:O54917, ECO:0000269|PubMed:9501179, ECO:0000269|PubMed:9689056, ECO:0000269|PubMed:9704927}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9689056, ECO:0000269|PubMed:9704927}.
O75462	reviewed	CRLF1_HUMAN	Cytokine receptor-like factor 1 (Cytokine-like factor 1) (CLF-1) (ZcytoR5)	CRLF1 UNQ288/PRO327	Homo sapiens (Human)	422	FUNCTION: In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system. {ECO:0000305|PubMed:26858303}.		cytokine-mediated signaling pathway [GO:0019221]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; ureteric bud development [GO:0001657]	CRLF-CLCF1 complex [GO:0097058]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]	CRLF-CLCF1 complex [GO:0097058]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; cytokine-mediated signaling pathway [GO:0019221]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9686600}.
O75469	reviewed	NR1I2_HUMAN	Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR)	NR1I2 PXR	Homo sapiens (Human)	434	FUNCTION: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}.		cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]	chromatin [GO:0000785]; intermediate filament cytoskeleton [GO:0045111]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear receptor binding [GO:0016922]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; intermediate filament cytoskeleton [GO:0045111]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear receptor binding [GO:0016922]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:12606758}.
O75473	reviewed	LGR5_HUMAN	Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38)	LGR5 GPR49 GPR67	Homo sapiens (Human)	907	FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}.	MISCELLANEOUS: LGR5 is used as a marker of adult tissue stem cells in the intestine, stomach, hair follicle, and mammary epithelium. {ECO:0000305|PubMed:19030762}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; G protein-coupled receptor signaling pathway [GO:0007186]; hair follicle development [GO:0001942]; inner ear development [GO:0048839]; oocyte differentiation [GO:0009994]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of cell population proliferation [GO:0042127]	Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; protein-hormone receptor activity [GO:0016500]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; protein-hormone receptor activity [GO:0016500]; transmembrane signaling receptor activity [GO:0004888]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; G protein-coupled receptor signaling pathway [GO:0007186]; hair follicle development [GO:0001942]; inner ear development [GO:0048839]; oocyte differentiation [GO:0009994]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). {ECO:0000269|PubMed:23439653}.
O75475	reviewed	PSIP1_HUMAN	PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)	PSIP1 DFS70 LEDGF PSIP2	Homo sapiens (Human)	530	FUNCTION: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}.	MISCELLANEOUS: [Isoform 1]: Less active than isoform 2 as transcriptional coactivator, but more abundant in cells.	chromatin remodeling [GO:0006338]; mRNA 5'-splice site recognition [GO:0000395]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]	cytosol [GO:0005829]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; RNA binding [GO:0003723]; supercoiled DNA binding [GO:0097100]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; RNA binding [GO:0003723]; supercoiled DNA binding [GO:0097100]; transcription coactivator activity [GO:0003713]; chromatin remodeling [GO:0006338]; mRNA 5'-splice site recognition [GO:0000395]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15642333, ECO:0000269|PubMed:9885563}. Note=Remains chromatin-associated throughout the cell cycle.
O75477	reviewed	ERLN1_HUMAN	Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1) (Protein KE04) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (SPFH domain-containing protein 1)	ERLIN1 C10orf69 KE04 KEO4 SPFH1	Homo sapiens (Human)	348	FUNCTION: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618). {ECO:0000269|PubMed:19240031, ECO:0000269|PubMed:24217618}.; FUNCTION: (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production. {ECO:0000269|PubMed:31810281}.		cholesterol metabolic process [GO:0008203]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of fatty acid biosynthetic process [GO:0045717]; regulation of cholesterol biosynthetic process [GO:0045540]; SREBP signaling pathway [GO:0032933]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane raft [GO:0045121]; protein-containing complex [GO:0032991]	cholesterol binding [GO:0015485]; ubiquitin protein ligase binding [GO:0031625]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane raft [GO:0045121]; protein-containing complex [GO:0032991]; cholesterol binding [GO:0015485]; ubiquitin protein ligase binding [GO:0031625]; cholesterol metabolic process [GO:0008203]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of fatty acid biosynthetic process [GO:0045717]; regulation of cholesterol biosynthetic process [GO:0045540]; SREBP signaling pathway [GO:0032933]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11118313, ECO:0000269|PubMed:16835267, ECO:0000269|PubMed:19240031}; Single-pass type II membrane protein {ECO:0000269|PubMed:11118313, ECO:0000269|PubMed:16835267, ECO:0000269|PubMed:19240031}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
O75478	reviewed	TAD2A_HUMAN	Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein)	TADA2A TADA2L KL04P	Homo sapiens (Human)	443	FUNCTION: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376). {ECO:0000250|UniProtKB:Q8CHV6, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:22644376}.		chromatin remodeling [GO:0006338]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of histone acetylation [GO:0035065]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]; chromatin remodeling [GO:0006338]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of histone acetylation [GO:0035065]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22644376}. Chromosome {ECO:0000250|UniProtKB:Q8CHV6}.
O75486	reviewed	SUPT3_HUMAN	Transcription initiation protein SPT3 homolog (SPT3-like protein)	SUPT3H SPT3	Homo sapiens (Human)	317	FUNCTION: Probable transcriptional activator. {ECO:0000269|PubMed:9787080}.		positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]	protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9726987}.
O75487	reviewed	GPC4_HUMAN	Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]	GPC4 UNQ474/PRO937	Homo sapiens (Human)	556	FUNCTION: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). {ECO:0000250}.		cell migration [GO:0016477]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of presynapse assembly [GO:1905606]; regulation of signal transduction [GO:0009966]; synaptic membrane adhesion [GO:0099560]; Wnt signaling pathway [GO:0016055]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]; cell migration [GO:0016477]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of presynapse assembly [GO:1905606]; regulation of signal transduction [GO:0009966]; synaptic membrane adhesion [GO:0099560]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.; SUBCELLULAR LOCATION: [Secreted glypican-4]: Secreted, extracellular space {ECO:0000250}.
O75489	reviewed	NDUS3_HUMAN	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC 7.1.1.2) (Complex I-30kD) (CI-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit)	NDUFS3	Homo sapiens (Human)	264	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:14729820, PubMed:30140060). Essential for the catalytic activity and assembly of complex I (PubMed:14729820, PubMed:24028823, PubMed:30140060). {ECO:0000269|PubMed:14729820, ECO:0000269|PubMed:24028823, ECO:0000269|PubMed:30140060}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of cell growth [GO:0030308]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]; substantia nigra development [GO:0021762]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]	electron transfer activity [GO:0009055]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; NADH dehydrogenase activity [GO:0003954]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; electron transfer activity [GO:0009055]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; NADH dehydrogenase activity [GO:0003954]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of cell growth [GO:0030308]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:18826940, ECO:0000305|PubMed:12611891, ECO:0000305|PubMed:17209039}; Peripheral membrane protein {ECO:0000305|PubMed:18826940}; Matrix side {ECO:0000269|PubMed:18826940}.
O75494	reviewed	SRS10_HUMAN	Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)	SRSF10 FUSIP1 FUSIP2 SFRS13A TASR	Homo sapiens (Human)	262	FUNCTION: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}.		cytosolic transport [GO:0016482]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of DNA-templated transcription [GO:0006355]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]	axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]; RS domain binding [GO:0050733]; unfolded protein binding [GO:0051082]	axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; RS domain binding [GO:0050733]; unfolded protein binding [GO:0051082]; cytosolic transport [GO:0016482]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of DNA-templated transcription [GO:0006355]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:26876937}. Cytoplasm {ECO:0000269|PubMed:11684676}.
O75496	reviewed	GEMI_HUMAN	Geminin	GMNN	Homo sapiens (Human)	209	FUNCTION: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:9635433, PubMed:14993212, PubMed:20129055, PubMed:24064211). It is degraded during the mitotic phase of the cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). {ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22615398, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:9635433}.		animal organ morphogenesis [GO:0009887]; DNA replication preinitiation complex assembly [GO:0071163]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA replication [GO:0008156]; negative regulation of DNA-templated DNA replication [GO:2000104]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of chromatin binding [GO:0035563]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of mitotic cell cycle [GO:0007346]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714]; animal organ morphogenesis [GO:0009887]; DNA replication preinitiation complex assembly [GO:0071163]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA replication [GO:0008156]; negative regulation of DNA-templated DNA replication [GO:2000104]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of chromatin binding [GO:0035563]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21543332}. Nucleus {ECO:0000269|PubMed:21543332}. Note=Mainly cytoplasmic but can be relocalized to the nucleus. {ECO:0000269|PubMed:21543332}.
O75503	reviewed	CLN5_HUMAN	Ceroid-lipofuscinosis neuronal protein 5 (Protein CLN5) [Cleaved into: Ceroid-lipofuscinosis neuronal protein 5, secreted form]	CLN5	Homo sapiens (Human)	358	FUNCTION: Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521). {ECO:0000269|PubMed:22431521}.		brain development [GO:0007420]; glycosylation [GO:0070085]; lysosomal lumen acidification [GO:0007042]; lysosome organization [GO:0007040]; neurogenesis [GO:0022008]; neuron maturation [GO:0042551]; positive regulation of GTP binding [GO:1904426]; protein catabolic process [GO:0030163]; retrograde transport, endosome to Golgi [GO:0042147]; signal peptide processing [GO:0006465]; visual perception [GO:0007601]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuolar lumen [GO:0005775]	hydrolase activity, acting on glycosyl bonds [GO:0016798]; mannose binding [GO:0005537]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuolar lumen [GO:0005775]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; mannose binding [GO:0005537]; brain development [GO:0007420]; glycosylation [GO:0070085]; lysosomal lumen acidification [GO:0007042]; lysosome organization [GO:0007040]; neurogenesis [GO:0022008]; neuron maturation [GO:0042551]; positive regulation of GTP binding [GO:1904426]; protein catabolic process [GO:0030163]; retrograde transport, endosome to Golgi [GO:0042147]; signal peptide processing [GO:0006465]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: [Ceroid-lipofuscinosis neuronal protein 5, secreted form]: Lysosome {ECO:0000269|PubMed:11971870, ECO:0000269|PubMed:20052765, ECO:0000269|PubMed:22431521, ECO:0000269|PubMed:24038957, ECO:0000269|PubMed:24058541}.; SUBCELLULAR LOCATION: [Ceroid-lipofuscinosis neuronal protein 5]: Membrane {ECO:0000269|PubMed:24038957}; Single-pass type II membrane protein {ECO:0000269|PubMed:24038957}. Note=An amphipathic anchor region facilitates its association with the membrane. {ECO:0000269|PubMed:24038957}.
O75506	reviewed	HSBP1_HUMAN	Heat shock factor-binding protein 1 (Nasopharyngeal carcinoma-associated antigen 13) (NPC-A-13)	HSBP1 HSF1BP	Homo sapiens (Human)	76	FUNCTION: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.		axonal transport of mitochondrion [GO:0019896]; cellular heat acclimation [GO:0070370]; endodermal cell differentiation [GO:0035987]; negative regulation of transcription by RNA polymerase II [GO:0000122]	axon cytoplasm [GO:1904115]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]	axon cytoplasm [GO:1904115]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]; axonal transport of mitochondrion [GO:0019896]; cellular heat acclimation [GO:0070370]; endodermal cell differentiation [GO:0035987]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus.
O75508	reviewed	CLD11_HUMAN	Claudin-11 (Oligodendrocyte-specific protein)	CLDN11 OSP OTM	Homo sapiens (Human)	207	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.		axon ensheathment [GO:0008366]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; spermatogenesis [GO:0007283]; tight junction assembly [GO:0120192]	axon [GO:0030424]; basal part of cell [GO:0045178]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; lipid droplet [GO:0005811]; neurofilament [GO:0005883]; plasma membrane [GO:0005886]; tight junction [GO:0070160]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	axon [GO:0030424]; basal part of cell [GO:0045178]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; lipid droplet [GO:0005811]; neurofilament [GO:0005883]; plasma membrane [GO:0005886]; tight junction [GO:0070160]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; axon ensheathment [GO:0008366]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; spermatogenesis [GO:0007283]; tight junction assembly [GO:0120192]	SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane {ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}.
O75509	reviewed	TNR21_HUMAN	Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)	TNFRSF21 DR6 UNQ437/PRO868	Homo sapiens (Human)	655	FUNCTION: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (PubMed:34012073). {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:22761420, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:9714541}.		adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; axonal fasciculation [GO:0007413]; B cell apoptotic process [GO:0001783]; cellular response to tumor necrosis factor [GO:0071356]; humoral immune response [GO:0006959]; myelination [GO:0042552]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of myelination [GO:0031642]; negative regulation of T cell proliferation [GO:0042130]; neuron apoptotic process [GO:0051402]; oligodendrocyte apoptotic process [GO:0097252]; regulation of oligodendrocyte differentiation [GO:0048713]; T cell receptor signaling pathway [GO:0050852]	axon [GO:0030424]; plasma membrane [GO:0005886]		axon [GO:0030424]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; axonal fasciculation [GO:0007413]; B cell apoptotic process [GO:0001783]; cellular response to tumor necrosis factor [GO:0071356]; humoral immune response [GO:0006959]; myelination [GO:0042552]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of myelination [GO:0031642]; negative regulation of T cell proliferation [GO:0042130]; neuron apoptotic process [GO:0051402]; oligodendrocyte apoptotic process [GO:0097252]; regulation of oligodendrocyte differentiation [GO:0048713]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19654028}; Single-pass type I membrane protein {ECO:0000269|PubMed:19654028}. Note=Endocytosed following oxidation in response to reactive oxygen species (ROS). {ECO:0000269|PubMed:34012073}.
O75521	reviewed	ECI2_HUMAN	Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1)	ECI2 DRS1 HCA88 PECI	Homo sapiens (Human)	394	FUNCTION: Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates. {ECO:0000269|PubMed:10419495}.		fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; fatty-acyl-CoA binding [GO:0000062]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; fatty-acyl-CoA binding [GO:0000062]; fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000250|UniProtKB:Q5XIC0}.; SUBCELLULAR LOCATION: [Isoform 2]: Peroxisome matrix {ECO:0000269|PubMed:10419495}.
O75525	reviewed	KHDR3_HUMAN	KH domain-containing, RNA-binding, signal transduction-associated protein 3 (RNA-binding protein T-Star) (Sam68-like mammalian protein 2) (SLM-2) (Sam68-like phosphotyrosine protein)	KHDRBS3 SALP SLM2	Homo sapiens (Human)	346	FUNCTION: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. {ECO:0000250|UniProtKB:Q9JLP1, ECO:0000250|UniProtKB:Q9R226, ECO:0000269|PubMed:10564820, ECO:0000269|PubMed:15901763, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:26758068}.; FUNCTION: (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression. {ECO:0000269|PubMed:11741900}.		mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10332027, ECO:0000269|PubMed:15901763}. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
O75528	reviewed	TADA3_HUMAN	Transcriptional adapter 3 (ADA3 homolog) (hADA3) (STAF54) (Transcriptional adapter 3-like) (ADA3-like protein)	TADA3 ADA3 TADA3L	Homo sapiens (Human)	432	FUNCTION: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:11707411, ECO:0000269|PubMed:19103755}.		chromatin organization [GO:0006325]; intracellular estrogen receptor signaling pathway [GO:0030520]; mitotic cell cycle [GO:0000278]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of protein phosphorylation [GO:0001932]; regulation of protein stability [GO:0031647]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]	nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; protein domain specific binding [GO:0019904]; transcription coactivator activity [GO:0003713]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; protein domain specific binding [GO:0019904]; transcription coactivator activity [GO:0003713]; chromatin organization [GO:0006325]; intracellular estrogen receptor signaling pathway [GO:0030520]; mitotic cell cycle [GO:0000278]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of protein phosphorylation [GO:0001932]; regulation of protein stability [GO:0031647]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9674425}.
O75529	reviewed	TAF5L_HUMAN	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (TAF5L) (PCAF-associated factor 65 beta) (PAF65-beta)	TAF5L PAF65B	Homo sapiens (Human)	589	FUNCTION: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity). {ECO:0000250|UniProtKB:Q91WQ5, ECO:0000305|PubMed:9674419}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	cytoplasmic ribonucleoprotein granule [GO:0036464]; histone acetyltransferase complex [GO:0000123]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]	transcription coactivator activity [GO:0003713]	cytoplasmic ribonucleoprotein granule [GO:0036464]; histone acetyltransferase complex [GO:0000123]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]; transcription coactivator activity [GO:0003713]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9674425}.
O75530	reviewed	EED_HUMAN	Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)	EED	Homo sapiens (Human)	441	FUNCTION: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:9584199}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; spinal cord development [GO:0021510]	chromosome [GO:0005694]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; enzyme activator activity [GO:0008047]; histone methyltransferase activity [GO:0042054]; identical protein binding [GO:0042802]; transcription corepressor binding [GO:0001222]	chromosome [GO:0005694]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; enzyme activator activity [GO:0008047]; histone methyltransferase activity [GO:0042054]; identical protein binding [GO:0042802]; transcription corepressor binding [GO:0001222]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; spinal cord development [GO:0021510]	SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes.
O75531	reviewed	BAF_HUMAN	Barrier-to-autointegration factor (Breakpoint cluster region protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed]	BANF1 BAF BCRG1	Homo sapiens (Human)	89	FUNCTION: Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA (PubMed:10908652, PubMed:11792822, PubMed:12163470, PubMed:18005698, PubMed:25991860, PubMed:28841419, PubMed:31796734, PubMed:32792394). Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging (PubMed:9465049). Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner (PubMed:28841419). Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface (PubMed:28841419). Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity (PubMed:32792394). Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses (PubMed:32792394). Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP-ribosyltransferase activity of PARP1 (PubMed:31796734). Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy (PubMed:25991860). In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication (PubMed:18005698). {ECO:0000269|PubMed:10908652, ECO:0000269|PubMed:11792822, ECO:0000269|PubMed:12163470, ECO:0000269|PubMed:18005698, ECO:0000269|PubMed:25991860, ECO:0000269|PubMed:28841419, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32792394, ECO:0000269|PubMed:9465049}.; FUNCTION: (Microbial infection) Exploited by retroviruses for inhibiting self-destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome (PubMed:9465049, PubMed:11005805, PubMed:16680152). EMD and BAF are cooperative cofactors of HIV-1 infection (PubMed:16680152). Association of EMD with the viral DNA requires the presence of BAF and viral integrase (PubMed:16680152). The association of viral DNA with chromatin requires the presence of BAF and EMD (PubMed:16680152). {ECO:0000269|PubMed:11005805, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:9465049}.		chromatin organization [GO:0006325]; DNA integration [GO:0015074]; mitotic nuclear membrane reassembly [GO:0007084]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein ADP-ribosylation [GO:0010836]; negative regulation of type I interferon production [GO:0032480]; negative regulation of viral genome replication [GO:0045071]; response to oxidative stress [GO:0006979]; response to virus [GO:0009615]	chromatin [GO:0000785]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	chromatin [GO:0000785]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; chromatin organization [GO:0006325]; DNA integration [GO:0015074]; mitotic nuclear membrane reassembly [GO:0007084]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein ADP-ribosylation [GO:0010836]; negative regulation of type I interferon production [GO:0032480]; negative regulation of viral genome replication [GO:0045071]; response to oxidative stress [GO:0006979]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18005698, ECO:0000269|PubMed:24600006}. Chromosome {ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:28841419, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32792394}. Nucleus envelope {ECO:0000269|PubMed:24600006}. Cytoplasm {ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18005698, ECO:0000269|PubMed:24600006}. Note=Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase (PubMed:16495336, PubMed:24600006). The phosphorylated form (by VRK1) shows a cytoplasmic localization whereas the unphosphorylated form locates almost exclusively in the nucleus (PubMed:16495336, PubMed:24600006). May be included in HIV-1 virions via its interaction with viral GAG polyprotein (PubMed:14645565). {ECO:0000269|PubMed:14645565, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:24600006}.
O75533	reviewed	SF3B1_HUMAN	Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)	SF3B1 SAP155	Homo sapiens (Human)	1304	FUNCTION: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved in the assembly of the 'E' complex (PubMed:10882114). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077) (Probable). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000305|PubMed:33509932}.		chromatin remodeling [GO:0006338]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of histone acetylation [GO:0035066]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; U2-type prespliceosome assembly [GO:1903241]	B-WICH complex [GO:0110016]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U11/U12 snRNP [GO:0034693]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935]	B-WICH complex [GO:0110016]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U11/U12 snRNP [GO:0034693]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935]; chromatin remodeling [GO:0006338]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of histone acetylation [GO:0035066]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300, ECO:0000269|PubMed:34023904}. Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.
O75534	reviewed	CSDE1_HUMAN	Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR)	CSDE1 D1S155E KIAA0885 NRU UNR	Homo sapiens (Human)	798	FUNCTION: RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}.		CRD-mediated mRNA stabilization [GO:0070934]; IRES-dependent viral translational initiation [GO:0075522]; male gonad development [GO:0008584]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; positive regulation of cytoplasmic translation [GO:2000767]; regulation of translational initiation [GO:0006446]; stress granule assembly [GO:0034063]	CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mCRD-mediated mRNA stability complex [GO:0106002]; P-body [GO:0000932]; plasma membrane [GO:0005886]	RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]	CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mCRD-mediated mRNA stability complex [GO:0106002]; P-body [GO:0000932]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; CRD-mediated mRNA stabilization [GO:0070934]; IRES-dependent viral translational initiation [GO:0075522]; male gonad development [GO:0008584]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; positive regulation of cytoplasmic translation [GO:2000767]; regulation of translational initiation [GO:0006446]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, Stress granule {ECO:0000305|PubMed:29395067}. Cytoplasm, P-body {ECO:0000269|PubMed:32354837}.
O75553	reviewed	DAB1_HUMAN	Disabled homolog 1	DAB1	Homo sapiens (Human)	588	FUNCTION: Adapter molecule functioning in neural development. May regulate SIAH1 activity. {ECO:0000250|UniProtKB:P97318}.		adult walking behavior [GO:0007628]; astrocyte differentiation [GO:0048708]; axonogenesis [GO:0007409]; cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration [GO:0021813]; cerebellum structural organization [GO:0021589]; dendrite development [GO:0016358]; Golgi localization [GO:0051645]; hippocampus development [GO:0021766]; lateral motor column neuron migration [GO:0097477]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell adhesion [GO:0007162]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; positive regulation of neuron differentiation [GO:0045666]; radial glia guided migration of Purkinje cell [GO:0021942]; radial glia-guided pyramidal neuron migration [GO:0140650]; receptor signaling pathway via JAK-STAT [GO:0007259]; small GTPase mediated signal transduction [GO:0007264]; ventral spinal cord development [GO:0021517]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; adult walking behavior [GO:0007628]; astrocyte differentiation [GO:0048708]; axonogenesis [GO:0007409]; cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration [GO:0021813]; cerebellum structural organization [GO:0021589]; dendrite development [GO:0016358]; Golgi localization [GO:0051645]; hippocampus development [GO:0021766]; lateral motor column neuron migration [GO:0097477]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell adhesion [GO:0007162]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; positive regulation of neuron differentiation [GO:0045666]; radial glia guided migration of Purkinje cell [GO:0021942]; radial glia-guided pyramidal neuron migration [GO:0140650]; receptor signaling pathway via JAK-STAT [GO:0007259]; small GTPase mediated signal transduction [GO:0007264]; ventral spinal cord development [GO:0021517]	
O75554	reviewed	WBP4_HUMAN	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4)	WBP4 FBP21 FNBP21	Homo sapiens (Human)	376	FUNCTION: Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:9724750, PubMed:19592703, PubMed:28781166). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9724750}.		mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]	proline-rich region binding [GO:0070064]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; proline-rich region binding [GO:0070064]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28781166}. Nucleus speckle {ECO:0000255|PROSITE-ProRule:PRU00130, ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:9724750}.
O75556	reviewed	SG2A1_HUMAN	Mammaglobin-B (Lacryglobin) (Lipophilin-C) (Mammaglobin-2) (Secretoglobin family 2A member 1)	SCGB2A1 LIPHC MGB2 UGB3	Homo sapiens (Human)	95	FUNCTION: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.		androgen receptor signaling pathway [GO:0030521]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; androgen receptor signaling pathway [GO:0030521]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O75558	reviewed	STX11_HUMAN	Syntaxin-11	STX11	Homo sapiens (Human)	287	FUNCTION: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.		exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]	endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
O75563	reviewed	SKAP2_HUMAN	Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)	SKAP2 PRAP RA70 SAPS SCAP2 SKAP55R	Homo sapiens (Human)	359	FUNCTION: May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}.		B cell activation [GO:0042113]; negative regulation of cell population proliferation [GO:0008285]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; B cell activation [GO:0042113]; negative regulation of cell population proliferation [GO:0008285]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12893833}.
O75564	reviewed	JERKY_HUMAN	Jerky protein homolog	JRK JH8	Homo sapiens (Human)	556	FUNCTION: May bind DNA. {ECO:0000250}.		positive regulation of canonical Wnt signaling pathway [GO:0090263]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	DNA binding [GO:0003677]; mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; DNA binding [GO:0003677]; mRNA binding [GO:0003729]; positive regulation of canonical Wnt signaling pathway [GO:0090263]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00583}.
O75569	reviewed	PRKRA_HUMAN	Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator)	PRKRA PACT RAX HSD-14 HSD14	Homo sapiens (Human)	313	FUNCTION: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250, ECO:0000269|PubMed:10336432, ECO:0000269|PubMed:11238927, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:16982605, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:9687506}.		cellular response to oxidative stress [GO:0034599]; immune response [GO:0006955]; middle ear morphogenesis [GO:0042474]; miRNA processing [GO:0035196]; negative regulation of cell population proliferation [GO:0008285]; outer ear morphogenesis [GO:0042473]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; pre-miRNA processing [GO:0031054]; protein stabilization [GO:0050821]; regulation of regulatory ncRNA processing [GO:0070920]; response to virus [GO:0009615]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422]; skeletal system morphogenesis [GO:0048705]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]	double-stranded RNA binding [GO:0003725]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; pre-miRNA binding [GO:0070883]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; siRNA binding [GO:0035197]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]; double-stranded RNA binding [GO:0003725]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; pre-miRNA binding [GO:0070883]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; siRNA binding [GO:0035197]; cellular response to oxidative stress [GO:0034599]; immune response [GO:0006955]; middle ear morphogenesis [GO:0042474]; miRNA processing [GO:0035196]; negative regulation of cell population proliferation [GO:0008285]; outer ear morphogenesis [GO:0042473]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; pre-miRNA processing [GO:0031054]; protein stabilization [GO:0050821]; regulation of regulatory ncRNA processing [GO:0070920]; response to virus [GO:0009615]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422]; skeletal system morphogenesis [GO:0048705]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Cytoplasm.
O75570	reviewed	RF1M_HUMAN	Peptide chain release factor 1, mitochondrial (MRF-1) (MtRF-1)	MTRF1	Homo sapiens (Human)	445	FUNCTION: Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-canonical stop codons AGG and AGA (PubMed:36302763, PubMed:36596788, PubMed:37141370). Non-canonical termination codons AGG and AGA are found at the end of MT-CO1/COX1 and MT-ND6/ND6 open reading frames, respectively (PubMed:37141370). Recognizes non-canonical stop codons via a network of interactions between the codon, MTRF1 and the ribosomal RNA (rRNA): in contrast to other translation release factors, which identify the codon in the A-site via direct interactions of amino acid side chains with the bases, MTRF1 repositions the first 2 bases of the stop codon to use an intricate network of interactions that includes residues of the release factor, the rRNA of the small ribosomal subunit, as well as neighboring bases of the mRNA (PubMed:37141370). {ECO:0000269|PubMed:36302763, ECO:0000269|PubMed:36596788, ECO:0000269|PubMed:37141370}.		mitochondrial translational termination [GO:0070126]	mitochondrion [GO:0005739]	translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]	mitochondrion [GO:0005739]; translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]; mitochondrial translational termination [GO:0070126]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:17803939, ECO:0000269|PubMed:37141370}.
O75575	reviewed	RPC9_HUMAN	DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17)	CRCP	Homo sapiens (Human)	148	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.; FUNCTION: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; neuropeptide signaling pathway [GO:0007218]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; DNA polymerase III complex [GO:0009360]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; RNA polymerase III complex [GO:0005666]	calcitonin gene-related peptide receptor activity [GO:0001635]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleotide binding [GO:0000166]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; DNA polymerase III complex [GO:0009360]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; RNA polymerase III complex [GO:0005666]; calcitonin gene-related peptide receptor activity [GO:0001635]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleotide binding [GO:0000166]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; neuropeptide signaling pathway [GO:0007218]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
O75578	reviewed	ITA10_HUMAN	Integrin alpha-10	ITGA10 UNQ468/PRO827	Homo sapiens (Human)	1167	FUNCTION: Integrin alpha-10/beta-1 is a receptor for collagen.		cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]	external side of plasma membrane [GO:0009897]; integrin alpha10-beta1 complex [GO:0034680]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]	collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]	external side of plasma membrane [GO:0009897]; integrin alpha10-beta1 complex [GO:0034680]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
O75581	reviewed	LRP6_HUMAN	Low-density lipoprotein receptor-related protein 6 (LRP-6)	LRP6	Homo sapiens (Human)	1613	FUNCTION: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552}.		canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340]; cell-cell adhesion [GO:0098609]; cellular response to cholesterol [GO:0071397]; chemical synaptic transmission [GO:0007268]; dopaminergic neuron differentiation [GO:0071542]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; response to peptide hormone [GO:0043434]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway involved in somitogenesis [GO:0090244]	cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Wnt signalosome [GO:1990909]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]	coreceptor activity [GO:0015026]; coreceptor activity involved in canonical Wnt signaling pathway [GO:1904928]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; kinase inhibitor activity [GO:0019210]; low-density lipoprotein particle receptor activity [GO:0005041]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; toxin transmembrane transporter activity [GO:0019534]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Wnt signalosome [GO:1990909]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]; coreceptor activity [GO:0015026]; coreceptor activity involved in canonical Wnt signaling pathway [GO:1904928]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; kinase inhibitor activity [GO:0019210]; low-density lipoprotein particle receptor activity [GO:0005041]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; toxin transmembrane transporter activity [GO:0019534]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340]; cell-cell adhesion [GO:0098609]; cellular response to cholesterol [GO:0071397]; chemical synaptic transmission [GO:0007268]; dopaminergic neuron differentiation [GO:0071542]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; response to peptide hormone [GO:0043434]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway involved in somitogenesis [GO:0090244]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26387593}; Single-pass type I membrane protein. Endoplasmic reticulum {ECO:0000269|PubMed:26387593}. Membrane raft {ECO:0000269|PubMed:23987510}. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalosomes. Chaperoned to the plasma membrane by MESD (By similarity). {ECO:0000250}.
O75582	reviewed	KS6A5_HUMAN	Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)	RPS6KA5 MSK1	Homo sapiens (Human)	802	FUNCTION: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}.	MISCELLANEOUS: Enzyme activity requires the presence of both kinase domains. {ECO:0000269|PubMed:9687510}.	axon guidance [GO:0007411]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; negative regulation of cytokine production [GO:0001818]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; regulation of postsynapse organization [GO:0099175]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; histone H2AS1 kinase activity [GO:0044024]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; histone H2AS1 kinase activity [GO:0044024]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; axon guidance [GO:0007411]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; negative regulation of cytokine production [GO:0001818]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; regulation of postsynapse organization [GO:0099175]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid.
O75586	reviewed	MED6_HUMAN	Mediator of RNA polymerase II transcription subunit 6 (Activator-recruited cofactor 33 kDa component) (ARC33) (Mediator complex subunit 6) (hMed6) (Renal carcinoma antigen NY-REN-28)	MED6 ARC33	Homo sapiens (Human)	246	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; ubiquitin protein ligase activity [GO:0061630]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Nucleus.
O75592	reviewed	MYCB2_HUMAN	E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Protein associated with Myc)	MYCBP2 KIAA0916 PAM	Homo sapiens (Human)	4678	FUNCTION: Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (PubMed:18308511, PubMed:29643511). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (By similarity). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity). Regulates axon guidance in the olfactory system (By similarity). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (By similarity). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown (PubMed:29643511). Regulates the internalization of TRPV1 in peripheral sensory neurons (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin (PubMed:18308511, PubMed:27278822). Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia (PubMed:26304119). May function as a facilitator or regulator of transcriptional activation by MYC (PubMed:9689053). Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). {ECO:0000250|UniProtKB:Q7TPH6, ECO:0000269|PubMed:18308511, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26304119, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:29643511, ECO:0000269|PubMed:9689053}.		axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; central nervous system projection neuron axonogenesis [GO:0021952]; circadian regulation of gene expression [GO:0032922]; negative regulation of protein catabolic process [GO:0042177]; neuromuscular process [GO:0050905]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; regulation of axon guidance [GO:1902667]; regulation of cytoskeleton organization [GO:0051493]; regulation of protein localization [GO:0032880]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; central nervous system projection neuron axonogenesis [GO:0021952]; circadian regulation of gene expression [GO:0032922]; negative regulation of protein catabolic process [GO:0042177]; neuromuscular process [GO:0050905]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; regulation of axon guidance [GO:1902667]; regulation of cytoskeleton organization [GO:0051493]; regulation of protein localization [GO:0032880]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26304119, ECO:0000269|PubMed:9689053}. Cell projection, axon {ECO:0000250|UniProtKB:Q7TPH6}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q7TPH6}. Note=Localizes to axon shafts and associates with microtubule cytoskeleton (By similarity). Translocates to the nucleus following interaction with sumoylated RANGAP1 (PubMed:26304119). {ECO:0000250|UniProtKB:Q7TPH6, ECO:0000269|PubMed:26304119}.
O75593	reviewed	FOXH1_HUMAN	Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (hFAST-1) (Forkhead activin signal transducer 2) (Fast-2)	FOXH1 FAST1 FAST2	Homo sapiens (Human)	365	FUNCTION: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). {ECO:0000269|PubMed:9702198}.		aorta morphogenesis [GO:0035909]; axial mesoderm development [GO:0048318]; cardiac right ventricle morphogenesis [GO:0003215]; cellular response to cytokine stimulus [GO:0071345]; embryonic heart tube anterior/posterior pattern specification [GO:0035054]; heart looping [GO:0001947]; hepatocyte differentiation [GO:0070365]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900164]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; secondary heart field specification [GO:0003139]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular trabecula myocardium morphogenesis [GO:0003222]	activin responsive factor complex [GO:0032444]; chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; co-SMAD binding [GO:0070410]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; nuclear androgen receptor binding [GO:0050681]; protein domain specific binding [GO:0019904]; R-SMAD binding [GO:0070412]; sequence-specific DNA binding [GO:0043565]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]	activin responsive factor complex [GO:0032444]; chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; co-SMAD binding [GO:0070410]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; nuclear androgen receptor binding [GO:0050681]; protein domain specific binding [GO:0019904]; R-SMAD binding [GO:0070412]; sequence-specific DNA binding [GO:0043565]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]; aorta morphogenesis [GO:0035909]; axial mesoderm development [GO:0048318]; cardiac right ventricle morphogenesis [GO:0003215]; cellular response to cytokine stimulus [GO:0071345]; embryonic heart tube anterior/posterior pattern specification [GO:0035054]; heart looping [GO:0001947]; hepatocyte differentiation [GO:0070365]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900164]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; secondary heart field specification [GO:0003139]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular trabecula myocardium morphogenesis [GO:0003222]	SUBCELLULAR LOCATION: Nucleus.
O75594	reviewed	PGRP1_HUMAN	Peptidoglycan recognition protein 1 (Peptidoglycan recognition protein short) (PGRP-S)	PGLYRP1 PGLYRP PGRP TNFSF3L SBBI68 UNQ639/PRO1269	Homo sapiens (Human)	196	FUNCTION: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed:9707603). Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane (PubMed:21247889, PubMed:26183779). In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement (PubMed:26654597). Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system (PubMed:30713770). Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity (PubMed:29083508, PubMed:28977785). Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (PubMed:28977785, PubMed:25595774). {ECO:0000269|PubMed:21247889, ECO:0000269|PubMed:25595774, ECO:0000269|PubMed:26183779, ECO:0000269|PubMed:26654597, ECO:0000269|PubMed:28977785, ECO:0000269|PubMed:29083508, ECO:0000269|PubMed:30713770, ECO:0000269|PubMed:9707603}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; biological process involved in interaction with host [GO:0051701]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; negative regulation of inflammatory response [GO:0050728]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; negative regulation of type II interferon production [GO:0032689]; peptidoglycan catabolic process [GO:0009253]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle lumen [GO:0097013]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	Hsp70 protein binding [GO:0030544]; molecular adaptor activity [GO:0060090]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; receptor ligand activity [GO:0048018]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle lumen [GO:0097013]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; Hsp70 protein binding [GO:0030544]; molecular adaptor activity [GO:0060090]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; receptor ligand activity [GO:0048018]; zinc ion binding [GO:0008270]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; biological process involved in interaction with host [GO:0051701]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; negative regulation of inflammatory response [GO:0050728]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; negative regulation of type II interferon production [GO:0032689]; peptidoglycan catabolic process [GO:0009253]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16354652}. Cytoplasmic granule {ECO:0000250}.
O75600	reviewed	KBL_HUMAN	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (AKB ligase) (EC 2.3.1.29) (Aminoacetone synthase) (Glycine acetyltransferase)	GCAT KBL	Homo sapiens (Human)	419	FUNCTION: Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA. {ECO:0000250|UniProtKB:Q0P5L8}.		amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058]; threonine catabolic process [GO:0006567]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	glycine C-acetyltransferase activity [GO:0008890]; pyridoxal phosphate binding [GO:0030170]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; glycine C-acetyltransferase activity [GO:0008890]; pyridoxal phosphate binding [GO:0030170]; amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058]; threonine catabolic process [GO:0006567]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q0P5L8}. Nucleus {ECO:0000269|PubMed:17688197}. Note=Translocates to the nucleus upon cold and osmotic stress. {ECO:0000269|PubMed:17688197}.
O75602	reviewed	SPAG6_HUMAN	Sperm-associated antigen 6 (Protein PF16 homolog) (Repro-SA-1) (Sperm flagellar protein)	SPAG6 PF16	Homo sapiens (Human)	509	FUNCTION: Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. {ECO:0000250, ECO:0000269|PubMed:10493827}.		epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; filopodium assembly [GO:0046847]; neuron projection extension [GO:1990138]; sperm axoneme assembly [GO:0007288]	acrosomal vesicle [GO:0001669]; axoneme [GO:0005930]; extracellular region [GO:0005576]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm principal piece [GO:0097228]	microtubule binding [GO:0008017]	acrosomal vesicle [GO:0001669]; axoneme [GO:0005930]; extracellular region [GO:0005576]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm principal piece [GO:0097228]; microtubule binding [GO:0008017]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; filopodium assembly [GO:0046847]; neuron projection extension [GO:1990138]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10493827}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:10493827}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9JLI7}. Note=Associated with microtubules. Detected on the sperm flagellum (PubMed:10493827). Localizes in the cilium axoneme in a SPEF1-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9JLI7, ECO:0000269|PubMed:10493827}.
O75603	reviewed	GCM2_HUMAN	Chorion-specific transcription factor GCMb (hGCMb) (GCM motif protein 2) (Glial cells missing homolog 2)	GCM2 GCMB	Homo sapiens (Human)	506	FUNCTION: Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development. {ECO:0000269|PubMed:20190276, ECO:0000269|PubMed:27745835, ECO:0000269|PubMed:9928992}.		gliogenesis [GO:0042063]; intracellular calcium ion homeostasis [GO:0006874]; intracellular phosphate ion homeostasis [GO:0030643]; parathyroid gland development [GO:0060017]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; gliogenesis [GO:0042063]; intracellular calcium ion homeostasis [GO:0006874]; intracellular phosphate ion homeostasis [GO:0030643]; parathyroid gland development [GO:0060017]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20190276}.
O75604	reviewed	UBP2_HUMAN	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2)	USP2 UBP41	Homo sapiens (Human)	605	FUNCTION: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19917254, PubMed:19838211). Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (PubMed:17290220, PubMed:19838211). Has no deubiquitinase activity against p53/TP53 (PubMed:17290220). Prevents MDM2-mediated degradation of MDM4 (PubMed:17290220). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (PubMed:19917254). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (By similarity). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (By similarity). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and BMAL1 (By similarity). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity). {ECO:0000250|UniProtKB:O88623, ECO:0000250|UniProtKB:Q5U349, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19838211, ECO:0000269|PubMed:19917254}.; FUNCTION: [Isoform 4]: Circadian clock output effector that regulates Ca(2+) absorption in the small intestine. Probably functions by regulating protein levels of the membrane scaffold protein NHERF4 in a rhythmic manner, and is therefore likely to control Ca(2+) membrane permeability mediated by the Ca(2+) channel TRPV6 in the intestine. {ECO:0000250|UniProtKB:O88623}.		cell cycle [GO:0007049]; circadian behavior [GO:0048512]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; locomotor rhythm [GO:0045475]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of mitotic cell cycle [GO:0045931]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of signal transduction by p53 class mediator [GO:1901796]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	cyclin binding [GO:0030332]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase binding [GO:0031625]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; cyclin binding [GO:0030332]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase binding [GO:0031625]; cell cycle [GO:0007049]; circadian behavior [GO:0048512]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; locomotor rhythm [GO:0045475]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of mitotic cell cycle [GO:0045931]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of signal transduction by p53 class mediator [GO:1901796]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O88623}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O88623}. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250|UniProtKB:Q5U349}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000250|UniProtKB:Q5U349}. Membrane {ECO:0000250|UniProtKB:O88623}; Peripheral membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:O88623}. Note=Predominantly expressed at membranes. {ECO:0000250|UniProtKB:O88623}.
O75607	reviewed	NPM3_HUMAN	Nucleoplasmin-3	NPM3	Homo sapiens (Human)	178	FUNCTION: Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning (PubMed:22362753, PubMed:20073534). Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM (PubMed:22362753). Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM (PubMed:15596447). {ECO:0000269|PubMed:15596447, ECO:0000269|PubMed:20073534, ECO:0000269|PubMed:22362753}.		chromatin remodeling [GO:0006338]; rRNA processing [GO:0006364]; rRNA transcription [GO:0009303]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; RNA binding [GO:0003723]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; RNA binding [GO:0003723]; chromatin remodeling [GO:0006338]; rRNA processing [GO:0006364]; rRNA transcription [GO:0009303]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11722795}. Nucleus, nucleolus {ECO:0000269|PubMed:15596447, ECO:0000269|PubMed:22362753}. Note=Mainly found in the granular component of the nucleolus. {ECO:0000269|PubMed:22362753}.
O75608	reviewed	LYPA1_HUMAN	Acyl-protein thioesterase 1 (APT-1) (hAPT1) (EC 3.1.2.-) (Lysophospholipase 1) (Lysophospholipase I) (LPL-I) (LysoPLA I) (Palmitoyl-protein hydrolase) (EC 3.1.2.22)	LYPLA1 APT1 LPL1	Homo sapiens (Human)	230	FUNCTION: Acts as a acyl-protein thioesterase (PubMed:19439193, PubMed:20418879). Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (PubMed:20418879). Has depalmitoylating activity toward KCNMA1 (PubMed:22399288). Could also depalmitoylate ADRB2 (PubMed:27481942). Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) (PubMed:19439193). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (PubMed:19439193). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (PubMed:21393252). {ECO:0000250|UniProtKB:P70470, ECO:0000269|PubMed:19439193, ECO:0000269|PubMed:20418879, ECO:0000269|PubMed:21393252, ECO:0000269|PubMed:22399288, ECO:0000269|PubMed:27481942}.		fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; protein depalmitoylation [GO:0002084]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	carboxylic ester hydrolase activity [GO:0052689]; lipase activity [GO:0016298]; lysophospholipase activity [GO:0004622]; palmitoyl-(protein) hydrolase activity [GO:0008474]; phospholipase activity [GO:0004620]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; carboxylic ester hydrolase activity [GO:0052689]; lipase activity [GO:0016298]; lysophospholipase activity [GO:0004622]; palmitoyl-(protein) hydrolase activity [GO:0008474]; phospholipase activity [GO:0004620]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; protein depalmitoylation [GO:0002084]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19439193}. Cell membrane {ECO:0000269|PubMed:19439193}. Nucleus membrane {ECO:0000269|PubMed:19439193}. Endoplasmic reticulum {ECO:0000269|PubMed:19439193}. Note=Shows predominantly a cytoplasmic localization with a weak expression in the cell membrane, nuclear membrane and endoplasmic reticulum. {ECO:0000269|PubMed:19439193}.
O75610	reviewed	LFTY1_HUMAN	Left-right determination factor 1 (Left-right determination factor B) (Protein lefty-1) (Protein lefty-B)	LEFTY1 LEFTB LEFTYB UNQ278/PRO317	Homo sapiens (Human)	366	FUNCTION: Required for left-right axis determination as a regulator of LEFTY2 and NODAL.		anterior/posterior axis specification [GO:0009948]; determination of left/right symmetry [GO:0007368]; heart morphogenesis [GO:0003007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; transforming growth factor beta receptor signaling pathway [GO:0007179]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; transforming growth factor beta receptor binding [GO:0005160]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; transforming growth factor beta receptor binding [GO:0005160]; anterior/posterior axis specification [GO:0009948]; determination of left/right symmetry [GO:0007368]; heart morphogenesis [GO:0003007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted.
O75616	reviewed	ERAL1_HUMAN	GTPase Era, mitochondrial (H-ERA) (hERA) (Conserved ERA-like GTPase) (CEGA) (ERA-W) (ERA-like protein 1)	ERAL1 HERA	Homo sapiens (Human)	437	FUNCTION: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. {ECO:0000269|PubMed:20430825, ECO:0000269|PubMed:20604745, ECO:0000269|PubMed:28449065}.	MISCELLANEOUS: [Isoform HERA-B]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	ribosomal small subunit assembly [GO:0000028]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GTP binding [GO:0005525]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; GTP binding [GO:0005525]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; ribosomal small subunit assembly [GO:0000028]	SUBCELLULAR LOCATION: Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane.
O75618	reviewed	DEDD_HUMAN	Death effector domain-containing protein (DEDPro1) (Death effector domain-containing testicular molecule) (FLDED-1)	DEDD DEDPRO1 DEFT KE05	Homo sapiens (Human)	318	FUNCTION: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). {ECO:0000250, ECO:0000269|PubMed:12235123}.		decidualization [GO:0046697]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; regulation of apoptotic process [GO:0042981]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	DNA binding [GO:0003677]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; DNA binding [GO:0003677]; decidualization [GO:0046697]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; regulation of apoptotic process [GO:0042981]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. {ECO:0000250}.
O75626	reviewed	PRDM1_HUMAN	PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1)	PRDM1 BLIMP1	Homo sapiens (Human)	825	FUNCTION: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). {ECO:0000250|UniProtKB:Q60636, ECO:0000269|PubMed:12626569, ECO:0000269|PubMed:1851123}.		adaptive immune response [GO:0002250]; aorta development [GO:0035904]; artery morphogenesis [GO:0048844]; cell fate commitment [GO:0045165]; coronary vasculature development [GO:0060976]; eye photoreceptor cell development [GO:0042462]; gene expression [GO:0010467]; germ cell development [GO:0007281]; heart valve development [GO:0003170]; innate immune response [GO:0045087]; intestinal epithelial cell development [GO:0060576]; kidney development [GO:0001822]; maternal placenta development [GO:0001893]; methylation [GO:0032259]; morphogenesis of a branching structure [GO:0001763]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; post-embryonic development [GO:0009791]; regulation of cell population proliferation [GO:0042127]; regulation of extrathymic T cell differentiation [GO:0033082]; regulation of natural killer cell differentiation [GO:0032823]; regulation of NK T cell differentiation [GO:0051136]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal bipolar neuron differentiation [GO:0060040]; sebum secreting cell proliferation [GO:1990654]; trophoblast giant cell differentiation [GO:0060707]; ventricular septum development [GO:0003281]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; adaptive immune response [GO:0002250]; aorta development [GO:0035904]; artery morphogenesis [GO:0048844]; cell fate commitment [GO:0045165]; coronary vasculature development [GO:0060976]; eye photoreceptor cell development [GO:0042462]; gene expression [GO:0010467]; germ cell development [GO:0007281]; heart valve development [GO:0003170]; innate immune response [GO:0045087]; intestinal epithelial cell development [GO:0060576]; kidney development [GO:0001822]; maternal placenta development [GO:0001893]; methylation [GO:0032259]; morphogenesis of a branching structure [GO:0001763]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; post-embryonic development [GO:0009791]; regulation of cell population proliferation [GO:0042127]; regulation of extrathymic T cell differentiation [GO:0033082]; regulation of natural killer cell differentiation [GO:0032823]; regulation of NK T cell differentiation [GO:0051136]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal bipolar neuron differentiation [GO:0060040]; sebum secreting cell proliferation [GO:1990654]; trophoblast giant cell differentiation [GO:0060707]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28842558}. Cytoplasm {ECO:0000269|PubMed:21421998}.
O75628	reviewed	REM1_HUMAN	GTP-binding protein REM 1 (GTPase-regulating endothelial cell sprouting) (Rad and Gem-like GTP-binding protein 1)	REM1 GES REM	Homo sapiens (Human)	298	FUNCTION: Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.		negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; regulation of skeletal muscle contraction by calcium ion signaling [GO:0014722]	I band [GO:0031674]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]	calcium channel regulator activity [GO:0005246]; calmodulin binding [GO:0005516]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; transmembrane transporter binding [GO:0044325]	I band [GO:0031674]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; calcium channel regulator activity [GO:0005246]; calmodulin binding [GO:0005516]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; transmembrane transporter binding [GO:0044325]; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; regulation of skeletal muscle contraction by calcium ion signaling [GO:0014722]	
O75629	reviewed	CREG1_HUMAN	Protein CREG1 (Cellular repressor of E1A-stimulated genes 1)	CREG1 CREG UNQ727/PRO1409	Homo sapiens (Human)	220	FUNCTION: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R. {ECO:0000269|PubMed:12934103, ECO:0000269|PubMed:9710587}.		autophagy [GO:0006914]; endocytosis [GO:0006897]; lysosomal lumen acidification [GO:0007042]; regulation of transcription by RNA polymerase II [GO:0006357]	azurophil granule lumen [GO:0035578]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; transcription regulator complex [GO:0005667]	transcription corepressor activity [GO:0003714]	azurophil granule lumen [GO:0035578]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; transcription regulator complex [GO:0005667]; transcription corepressor activity [GO:0003714]; autophagy [GO:0006914]; endocytosis [GO:0006897]; lysosomal lumen acidification [GO:0007042]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10815803}.
O75631	reviewed	UPK3A_HUMAN	Uroplakin-3a (UP3a) (Uroplakin III) (UPIII)	UPK3A UPK3	Homo sapiens (Human)	287	FUNCTION: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). {ECO:0000250}.		cell morphogenesis [GO:0000902]; epithelial cell differentiation [GO:0030855]; kidney development [GO:0001822]; potassium ion homeostasis [GO:0055075]; sodium ion homeostasis [GO:0055078]; urea transport [GO:0015840]; urinary bladder development [GO:0060157]; water transport [GO:0006833]	apical plasma membrane urothelial plaque [GO:0120001]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]		apical plasma membrane urothelial plaque [GO:0120001]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; cell morphogenesis [GO:0000902]; epithelial cell differentiation [GO:0030855]; kidney development [GO:0001822]; potassium ion homeostasis [GO:0055075]; sodium ion homeostasis [GO:0055078]; urea transport [GO:0015840]; urinary bladder development [GO:0060157]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}.
O75636	reviewed	FCN3_HUMAN	Ficolin-3 (Collagen/fibrinogen domain-containing lectin 3 p35) (Collagen/fibrinogen domain-containing protein 3) (Hakata antigen)	FCN3 FCNH HAKA1	Homo sapiens (Human)	299	FUNCTION: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. {ECO:0000269|PubMed:11907111, ECO:0000269|PubMed:17215869}.		cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation [GO:0006956]; complement activation, lectin pathway [GO:0001867]; defense response to virus [GO:0051607]; negative regulation of RNA biosynthetic process [GO:1902679]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]; recognition of apoptotic cell [GO:0043654]	blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370]	antigen binding [GO:0003823]; carbohydrate binding [GO:0030246]; carbohydrate derivative binding [GO:0097367]; metal ion binding [GO:0046872]; signaling receptor binding [GO:0005102]	blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370]; antigen binding [GO:0003823]; carbohydrate binding [GO:0030246]; carbohydrate derivative binding [GO:0097367]; metal ion binding [GO:0046872]; signaling receptor binding [GO:0005102]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation [GO:0006956]; complement activation, lectin pathway [GO:0001867]; defense response to virus [GO:0051607]; negative regulation of RNA biosynthetic process [GO:1902679]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]; recognition of apoptotic cell [GO:0043654]	SUBCELLULAR LOCATION: Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct.
O75638	reviewed	CTAG2_HUMAN	Cancer/testis antigen 2 (CT2) (Autoimmunogenic cancer/testis antigen NY-ESO-2) (Cancer/testis antigen 6.2) (CT6.2) (L antigen family member 1) (LAGE-1)	CTAG2 ESO2 LAGE1	Homo sapiens (Human)	210			tRNA threonylcarbamoyladenosine metabolic process [GO:0070525]	centrosome [GO:0005813]		centrosome [GO:0005813]; tRNA threonylcarbamoyladenosine metabolic process [GO:0070525]	
O75643	reviewed	U520_HUMAN	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)	SNRNP200 ASCC3L1 BRR2 HELIC2 KIAA0788	Homo sapiens (Human)	2136	FUNCTION: Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}.		cis assembly of pre-catalytic spliceosome [GO:0000354]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [GO:0000388]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; cis assembly of pre-catalytic spliceosome [GO:0000354]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [GO:0000388]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9539711}.
O75648	reviewed	MTU1_HUMAN	Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) (MTO2 homolog)	TRMU MTU1 TRMT1	Homo sapiens (Human)	421	FUNCTION: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. {ECO:0000269|PubMed:15509579, ECO:0000269|PubMed:15944150, ECO:0000269|PubMed:16826519}.	MISCELLANEOUS: During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity). {ECO:0000250}.	tRNA wobble position uridine thiolation [GO:0002143]	mitochondrion [GO:0005739]	ATP binding [GO:0005524]; tRNA binding [GO:0000049]; tRNA-5-taurinomethyluridine 2-sulfurtransferase [GO:0061708]	mitochondrion [GO:0005739]; ATP binding [GO:0005524]; tRNA binding [GO:0000049]; tRNA-5-taurinomethyluridine 2-sulfurtransferase [GO:0061708]; tRNA wobble position uridine thiolation [GO:0002143]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15509579, ECO:0000269|PubMed:15944150, ECO:0000269|PubMed:16513084, ECO:0000269|PubMed:16826519}.
O75663	reviewed	TIPRL_HUMAN	TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP)	TIPRL	Homo sapiens (Human)	272	FUNCTION: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. {ECO:0000269|PubMed:17384681, ECO:0000269|PubMed:26717153}.		DNA damage checkpoint signaling [GO:0000077]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; TOR signaling [GO:0031929]	cytosol [GO:0005829]		cytosol [GO:0005829]; DNA damage checkpoint signaling [GO:0000077]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; TOR signaling [GO:0031929]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17944932}.
O75665	reviewed	OFD1_HUMAN	Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A)	OFD1 CXorf5	Homo sapiens (Human)	1012	FUNCTION: Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}.		cilium assembly [GO:0060271]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; nucleus [GO:0005634]	alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; nucleus [GO:0005634]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; cilium assembly [GO:0060271]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:12595504, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20230748, ECO:0000269|PubMed:26643951}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17761535}. Nucleus {ECO:0000269|PubMed:17761535}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:26643951}. Note=Localizes to centriole distal ends and to centriolar satellites (PubMed:20230748, PubMed:24121310). Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP (PubMed:26643951). {ECO:0000269|PubMed:26643951}.
O75674	reviewed	TM1L1_HUMAN	TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1)	TOM1L1 SRCASM	Homo sapiens (Human)	476	FUNCTION: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). {ECO:0000250}.		activation of protein kinase activity [GO:0032147]; negative regulation of mitotic nuclear division [GO:0045839]; positive regulation of protein autophosphorylation [GO:0031954]; protein transport [GO:0015031]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi stack [GO:0005795]; lysosome [GO:0005764]; membrane [GO:0016020]	clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; ubiquitin binding [GO:0043130]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi stack [GO:0005795]; lysosome [GO:0005764]; membrane [GO:0016020]; clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; ubiquitin binding [GO:0043130]; activation of protein kinase activity [GO:0032147]; negative regulation of mitotic nuclear division [GO:0045839]; positive regulation of protein autophosphorylation [GO:0031954]; protein transport [GO:0015031]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack. Endosome membrane {ECO:0000305}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=A small proportion is membrane-associated. {ECO:0000250}.
O75676	reviewed	KS6A4_HUMAN	Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)	RPS6KA4 MSK2	Homo sapiens (Human)	772	FUNCTION: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}.	MISCELLANEOUS: Enzyme activity requires the presence of both kinase domains. {ECO:0000250|UniProtKB:O75582}.	inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; negative regulation of cytokine production [GO:0001818]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]	ATP binding [GO:0005524]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosomal protein S6 kinase activity [GO:0004711]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]; ATP binding [GO:0005524]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosomal protein S6 kinase activity [GO:0004711]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; negative regulation of cytokine production [GO:0001818]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:9792677}.
O75677	reviewed	RFPL1_HUMAN	Ret finger protein-like 1 (RING finger protein 78)	RFPL1 RFPL1L RNF78	Homo sapiens (Human)	317	FUNCTION: Negatively regulates the G2-M phase transition, possibly by promoting cyclin B1/CCNB1 and CDK1 proteasomal degradation and thereby preventing their accumulation during interphase. {ECO:0000269|PubMed:20725088}.		cell cycle [GO:0007049]; innate immune response [GO:0045087]; negative regulation of cell division [GO:0051782]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001272]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; cell cycle [GO:0007049]; innate immune response [GO:0045087]; negative regulation of cell division [GO:0051782]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001272]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20725088}. Nucleus {ECO:0000269|PubMed:20725088}. Note=A higher concentration is observed in the cytoplasm compared to the nucleus. {ECO:0000269|PubMed:20725088}.
O75679	reviewed	RFPL3_HUMAN	Ret finger protein-like 3	RFPL3	Homo sapiens (Human)	317	FUNCTION: (Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex. {ECO:0000269|PubMed:25107902}.		innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25107902}. Nucleus {ECO:0000269|PubMed:25107902}. Note=A higher concentration of RFPL3 is observed in the cytoplasm compared to the nucleus. {ECO:0000269|PubMed:25107902}.
O75688	reviewed	PPM1B_HUMAN	Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)	PPM1B PP2CB	Homo sapiens (Human)	479	FUNCTION: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}.		N-terminal protein myristoylation [GO:0006499]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein dephosphorylation [GO:0006470]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]	magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; N-terminal protein myristoylation [GO:0006499]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22781750}. Membrane {ECO:0000250|UniProtKB:P36993}; Lipid-anchor {ECO:0000250|UniProtKB:P36993}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250|UniProtKB:P36993}.
O75689	reviewed	ADAP1_HUMAN	Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25)	ADAP1 CENTA1	Homo sapiens (Human)	374	FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). {ECO:0000269|PubMed:10448098, ECO:0000303|PubMed:10333475, ECO:0000305}.		cell surface receptor signaling pathway [GO:0007166]; regulation of GTPase activity [GO:0043087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; metal ion binding [GO:0046872]; phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; metal ion binding [GO:0046872]; phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; cell surface receptor signaling pathway [GO:0007166]; regulation of GTPase activity [GO:0043087]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.
O75691	reviewed	UTP20_HUMAN	Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6)	UTP20 DRIM	Homo sapiens (Human)	2785	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}.		endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; negative regulation of cell population proliferation [GO:0008285]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	90S preribosome [GO:0030686]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; preribosome, small subunit precursor [GO:0030688]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	90S preribosome [GO:0030686]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; preribosome, small subunit precursor [GO:0030688]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; negative regulation of cell population proliferation [GO:0008285]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16458307, ECO:0000269|PubMed:34516797}. Note=Colocalizes with NCL in the nucleolus.
O75694	reviewed	NU155_HUMAN	Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155)	NUP155 KIAA0791	Homo sapiens (Human)	1391	FUNCTION: Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}.		atrial cardiac muscle cell action potential [GO:0086014]; miRNA processing [GO:0035196]; mRNA export from nucleus [GO:0006406]; nuclear envelope organization [GO:0006998]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; protein localization to nuclear inner membrane [GO:0036228]; RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611]; structural constituent of nuclear pore [GO:0017056]; atrial cardiac muscle cell action potential [GO:0086014]; miRNA processing [GO:0035196]; mRNA export from nucleus [GO:0006406]; nuclear envelope organization [GO:0006998]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; protein localization to nuclear inner membrane [GO:0036228]; RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P37199}. Nucleus membrane {ECO:0000250|UniProtKB:P37199}; Peripheral membrane protein {ECO:0000250|UniProtKB:P37199}; Cytoplasmic side {ECO:0000250|UniProtKB:P37199}. Nucleus membrane {ECO:0000250|UniProtKB:P37199}; Peripheral membrane protein {ECO:0000250|UniProtKB:P37199}; Nucleoplasmic side {ECO:0000250|UniProtKB:P37199}. Note=In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis. {ECO:0000250|UniProtKB:P37199}.
O75695	reviewed	XRP2_HUMAN	Protein XRP2	RP2	Homo sapiens (Human)	350	FUNCTION: Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. {ECO:0000269|PubMed:11847227, ECO:0000269|PubMed:18376416, ECO:0000269|PubMed:20106869, ECO:0000269|PubMed:22085962}.		cilium assembly [GO:0060271]; post-Golgi vesicle-mediated transport [GO:0006892]; protein folding [GO:0006457]; protein transport [GO:0015031]; visual perception [GO:0007601]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; periciliary membrane compartment [GO:1990075]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; magnesium ion binding [GO:0000287]; unfolded protein binding [GO:0051082]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; periciliary membrane compartment [GO:1990075]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; magnesium ion binding [GO:0000287]; unfolded protein binding [GO:0051082]; cilium assembly [GO:0060271]; post-Golgi vesicle-mediated transport [GO:0006892]; protein folding [GO:0006457]; protein transport [GO:0015031]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10942419, ECO:0000269|PubMed:12417528}; Lipid-anchor {ECO:0000269|PubMed:10942419}; Cytoplasmic side {ECO:0000269|PubMed:10942419}. Cell projection, cilium {ECO:0000269|PubMed:20106869}. Note=Detected predominantly at the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus. {ECO:0000269|PubMed:12417528}.
O75712	reviewed	CXB3_HUMAN	Gap junction beta-3 protein (Connexin-31) (Cx31)	GJB3 CX31	Homo sapiens (Human)	270	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.		cell-cell signaling [GO:0007267]; cellular response to retinoic acid [GO:0071300]; in utero embryonic development [GO:0001701]; placenta development [GO:0001890]; skin development [GO:0043588]; spermatogenesis [GO:0007283]	cell junction [GO:0030054]; connexin complex [GO:0005922]; cytoplasm [GO:0005737]; gap junction [GO:0005921]; intracellular membrane-bounded organelle [GO:0043231]	gap junction channel activity [GO:0005243]	cell junction [GO:0030054]; connexin complex [GO:0005922]; cytoplasm [GO:0005737]; gap junction [GO:0005921]; intracellular membrane-bounded organelle [GO:0043231]; gap junction channel activity [GO:0005243]; cell-cell signaling [GO:0007267]; cellular response to retinoic acid [GO:0071300]; in utero embryonic development [GO:0001701]; placenta development [GO:0001890]; skin development [GO:0043588]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
O75716	reviewed	STK16_HUMAN	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) (hPSK)	STK16 MPSK1 PKL12 TSF1	Homo sapiens (Human)	305	FUNCTION: Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. {ECO:0000269|PubMed:10364453}.		cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associates with Golgi and Golgi-derived vesicles. {ECO:0000250}.
O75717	reviewed	WDHD1_HUMAN	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1)	WDHD1 AND1	Homo sapiens (Human)	1129	FUNCTION: Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}.		DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; mitotic cell cycle [GO:0000278]	cytoplasm [GO:0005737]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]	cytoplasm [GO:0005737]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000305|PubMed:34694004, ECO:0000305|PubMed:35585232}.
O75718	reviewed	CRTAP_HUMAN	Cartilage-associated protein	CRTAP CASP	Homo sapiens (Human)	401	FUNCTION: Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. {ECO:0000269|PubMed:17055431}.		chaperone-mediated protein folding [GO:0061077]; collagen fibril organization [GO:0030199]; negative regulation of post-translational protein modification [GO:1901874]; protein stabilization [GO:0050821]; spermatogenesis [GO:0007283]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]; chaperone-mediated protein folding [GO:0061077]; collagen fibril organization [GO:0030199]; negative regulation of post-translational protein modification [GO:1901874]; protein stabilization [GO:0050821]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
O75746	reviewed	S2512_HUMAN	Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Araceli hiperlarga) (Aralar) (Aralar1) (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12)	SLC25A12 AGC1 ARALAR1	Homo sapiens (Human)	678	FUNCTION: Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575). Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). {ECO:0000269|PubMed:11566871, ECO:0000269|PubMed:19641205, ECO:0000269|PubMed:24515575}.		aspartate family amino acid metabolic process [GO:0009066]; aspartate transmembrane transport [GO:0015810]; gluconeogenesis [GO:0006094]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; response to calcium ion [GO:0051592]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	3-sulfino-L-alanine: proton, glutamate antiporter activity [GO:0000514]; acidic amino acid transmembrane transporter activity [GO:0015172]; aspartate:glutamate, proton antiporter activity [GO:0000515]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; 3-sulfino-L-alanine: proton, glutamate antiporter activity [GO:0000514]; acidic amino acid transmembrane transporter activity [GO:0015172]; aspartate:glutamate, proton antiporter activity [GO:0000515]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; aspartate family amino acid metabolic process [GO:0009066]; aspartate transmembrane transport [GO:0015810]; gluconeogenesis [GO:0006094]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11566871, ECO:0000269|PubMed:19641205, ECO:0000269|PubMed:24515575, ECO:0000269|PubMed:9722566}; Multi-pass membrane protein {ECO:0000269|PubMed:11566871}.
O75747	reviewed	P3C2G_HUMAN	Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (PI3K-C2-gamma) (PtdIns-3-kinase C2 subunit gamma) (EC 2.7.1.137) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-gamma)	PIK3C2G	Homo sapiens (Human)	1445	FUNCTION: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (By similarity). May play a role in SDF1A-stimulated chemotaxis (By similarity). {ECO:0000250|UniProtKB:O70167, ECO:0000250|UniProtKB:O70173}.		chemotaxis [GO:0006935]; modulation by host of viral process [GO:0044788]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol kinase activity [GO:0052742]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol kinase activity [GO:0052742]; chemotaxis [GO:0006935]; modulation by host of viral process [GO:0044788]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:O70167}; Peripheral membrane protein {ECO:0000250|UniProtKB:O70167}.
O75751	reviewed	S22A3_HUMAN	Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) (OCT3)	SLC22A3 EMTH OCT3	Homo sapiens (Human)	556	FUNCTION: Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10196521, PubMed:10966924, PubMed:12538837, PubMed:17460754, PubMed:20858707). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:10966924). Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter (PubMed:12538837). Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:10196521, PubMed:16581093, PubMed:20858707). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (PubMed:17460754). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (PubMed:10966924). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). Mediates the transport of polyamine spermidine and putrescine (By similarity). Mediates the bidirectional transport of polyamine agmatine (PubMed:12538837). Also transports guanidine (PubMed:10966924). May also mediate intracellular transport of organic cations, thereby playing a role in amine metabolism and intracellular signaling (By similarity). {ECO:0000250|UniProtKB:O88446, ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924, ECO:0000269|PubMed:12538837, ECO:0000269|PubMed:16581093, ECO:0000269|PubMed:17460754, ECO:0000269|PubMed:20858707, ECO:0000305|PubMed:35307651}.	MISCELLANEOUS: Mediates the uptake of clinically used drugs including neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) and platinum-based drug oxaliplatin (PubMed:10196521, PubMed:10966924, PubMed:12538837, PubMed:15817714, PubMed:16263091, PubMed:16914559, PubMed:16581093, PubMed:20858707). Plays a role in the anticancer activity of oxaliplatin and may contribute to antitumor specificity (PubMed:16914559). {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924, ECO:0000269|PubMed:12538837, ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:16263091, ECO:0000269|PubMed:16581093, ECO:0000269|PubMed:16914559, ECO:0000269|PubMed:20858707}.	dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; epinephrine uptake [GO:0051625]; histamine metabolic process [GO:0001692]; histamine transport [GO:0051608]; histamine uptake [GO:0051615]; monoamine transport [GO:0015844]; monoatomic ion transport [GO:0006811]; monocarboxylic acid transport [GO:0015718]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; organic anion transport [GO:0015711]; organic cation transport [GO:0015695]; purine-containing compound transmembrane transport [GO:0072530]; quaternary ammonium group transport [GO:0015697]; regulation of appetite [GO:0032098]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; toxin transport [GO:1901998]; transport across blood-brain barrier [GO:0150104]; xenobiotic transport [GO:0042908]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endomembrane system [GO:0012505]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; spermidine transmembrane transporter activity [GO:0015606]; toxin transmembrane transporter activity [GO:0019534]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endomembrane system [GO:0012505]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; spermidine transmembrane transporter activity [GO:0015606]; toxin transmembrane transporter activity [GO:0019534]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; epinephrine uptake [GO:0051625]; histamine metabolic process [GO:0001692]; histamine transport [GO:0051608]; histamine uptake [GO:0051615]; monoamine transport [GO:0015844]; monoatomic ion transport [GO:0006811]; monocarboxylic acid transport [GO:0015718]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; organic anion transport [GO:0015711]; organic cation transport [GO:0015695]; purine-containing compound transmembrane transport [GO:0072530]; quaternary ammonium group transport [GO:0015697]; regulation of appetite [GO:0032098]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; toxin transport [GO:1901998]; transport across blood-brain barrier [GO:0150104]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:20858707}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:16263091}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:15817714}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000250|UniProtKB:O88446}. Endomembrane system {ECO:0000250|UniProtKB:O88446}. Nucleus membrane {ECO:0000250|UniProtKB:O88446}. Nucleus outer membrane {ECO:0000250|UniProtKB:O88446}. Note=Localized to the apical/brush border membrane of enterocytes (PubMed:16263091). Localized to the luminal/apical membrane of ciliated epithelial cells in bronchi (PubMed:15817714). Localized to the basolateral membrane of intermediate cells in bronchi (PubMed:15817714). Localized to the entire plasma membrane of basal cells in bronchi (PubMed:15817714). {ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:16263091}.
O75752	reviewed	B3GL1_HUMAN	UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (Beta-1,3-GalNAc-T1) (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-GalTase 3) (Beta3Gal-T3) (Beta3GalT3) (b3Gal-T3) (Beta-3-Gx-T3) (Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase) (Globoside synthase) (UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase)	B3GALNT1 B3GALT3 UNQ531/PRO1074	Homo sapiens (Human)	331	FUNCTION: Transfers N-acetylgalactosamine onto globotriaosylceramide (PubMed:10993897). Plays a critical role in preimplantation stage embryonic development (By similarity). {ECO:0000250|UniProtKB:Q920V1, ECO:0000269|PubMed:10993897}.		glycosphingolipid metabolic process [GO:0006687]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity [GO:0047273]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity [GO:0047273]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; glycosphingolipid metabolic process [GO:0006687]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein.
O75762	reviewed	TRPA1_HUMAN	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor)	TRPA1 ANKTM1	Homo sapiens (Human)	1119	FUNCTION: Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:25855297). Shows 8-fold preference for divalent over monovalent cations (PubMed:31447178). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of irritants, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an irritant from tears gas and vehicle exhaust fumes (PubMed:25389312, PubMed:27241698, PubMed:30878828, PubMed:20547126). Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). Is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:25855297, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31447178, ECO:0000305|PubMed:23199233}.		calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to organic substance [GO:0071310]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transport [GO:0006811]; protein homotetramerization [GO:0051289]; response to cold [GO:0009409]; response to organic cyclic compound [GO:0014070]; response to organic substance [GO:0010033]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]	plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]	calcium channel activity [GO:0005262]; calcium-release channel activity [GO:0015278]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; temperature-gated cation channel activity [GO:0097604]	plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]; calcium channel activity [GO:0005262]; calcium-release channel activity [GO:0015278]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; temperature-gated cation channel activity [GO:0097604]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to organic substance [GO:0071310]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transport [GO:0006811]; protein homotetramerization [GO:0051289]; response to cold [GO:0009409]; response to organic cyclic compound [GO:0014070]; response to organic substance [GO:0010033]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:25855297}; Multi-pass membrane protein {ECO:0000305}.
O75771	reviewed	RA51D_HUMAN	DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD)	RAD51D RAD51L3	Homo sapiens (Human)	328	FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM. {ECO:0000269|PubMed:10871607, ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11834724, ECO:0000269|PubMed:11842113, ECO:0000269|PubMed:12975363, ECO:0000269|PubMed:15109494, ECO:0000269|PubMed:23149936}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; reciprocal meiotic recombination [GO:0007131]; regulation of cell cycle [GO:0051726]; strand invasion [GO:0042148]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; gamma-tubulin binding [GO:0043015]; single-stranded DNA binding [GO:0003697]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; gamma-tubulin binding [GO:0043015]; single-stranded DNA binding [GO:0003697]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; reciprocal meiotic recombination [GO:0007131]; regulation of cell cycle [GO:0051726]; strand invasion [GO:0042148]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, telomere.
O75781	reviewed	PALM_HUMAN	Paralemmin-1 (Paralemmin)	PALM KIAA0270	Homo sapiens (Human)	387	FUNCTION: Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to electrical stimulus [GO:0071257]; cytoskeleton organization [GO:0007010]; negative regulation of dopamine receptor signaling pathway [GO:0060160]; positive regulation of filopodium assembly [GO:0051491]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]; synapse maturation [GO:0060074]	apicolateral plasma membrane [GO:0016327]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; dendritic spine [GO:0043197]; filopodium membrane [GO:0031527]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	D3 dopamine receptor binding [GO:0031750]	apicolateral plasma membrane [GO:0016327]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; dendritic spine [GO:0043197]; filopodium membrane [GO:0031527]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; D3 dopamine receptor binding [GO:0031750]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to electrical stimulus [GO:0071257]; cytoskeleton organization [GO:0007010]; negative regulation of dopamine receptor signaling pathway [GO:0060160]; positive regulation of filopodium assembly [GO:0051491]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]; synapse maturation [GO:0060074]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14978216}; Lipid-anchor {ECO:0000269|PubMed:14978216}; Cytoplasmic side {ECO:0000269|PubMed:14978216}. Cell projection, filopodium membrane {ECO:0000269|PubMed:14978216}; Lipid-anchor {ECO:0000269|PubMed:14978216}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Apicolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity.
O75783	reviewed	RHBL1_HUMAN	Rhomboid-related protein 1 (RRP) (EC 3.4.21.105) (Rhomboid-like protein 1)	RHBDL1 RHBDL	Homo sapiens (Human)	438	FUNCTION: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. {ECO:0000250}.		proteolysis [GO:0006508]; signal transduction [GO:0007165]	membrane [GO:0016020]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]	membrane [GO:0016020]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
O75787	reviewed	RENR_HUMAN	Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment]	ATP6AP2 ATP6IP2 CAPER ELDF10 HT028 MSTP009 PSEC0072	Homo sapiens (Human)	350	FUNCTION: Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system (PubMed:12045255, PubMed:29127204, PubMed:30374053, PubMed:32276428). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (PubMed:12045255). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (PubMed:12045255). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity). {ECO:0000250|UniProtKB:Q9CYN9, ECO:0000269|PubMed:12045255, ECO:0000269|PubMed:29127204, ECO:0000269|PubMed:30374053, ECO:0000269|PubMed:32276428}.		angiotensin maturation [GO:0002003]; central nervous system maturation [GO:0021626]; endosomal lumen acidification [GO:0048388]; eye pigmentation [GO:0048069]; Golgi lumen acidification [GO:0061795]; head morphogenesis [GO:0060323]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transforming growth factor beta1 production [GO:0032914]; positive regulation of Wnt signaling pathway [GO:0030177]; proton transmembrane transport [GO:1902600]; regulation of MAPK cascade [GO:0043408]; rostrocaudal neural tube patterning [GO:0021903]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	autophagosome membrane [GO:0000421]; axon [GO:0030424]; clathrin-coated vesicle membrane [GO:0030665]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]; tertiary granule membrane [GO:0070821]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	signaling receptor activity [GO:0038023]	autophagosome membrane [GO:0000421]; axon [GO:0030424]; clathrin-coated vesicle membrane [GO:0030665]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]; tertiary granule membrane [GO:0070821]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; signaling receptor activity [GO:0038023]; angiotensin maturation [GO:0002003]; central nervous system maturation [GO:0021626]; endosomal lumen acidification [GO:0048388]; eye pigmentation [GO:0048069]; Golgi lumen acidification [GO:0061795]; head morphogenesis [GO:0060323]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transforming growth factor beta1 production [GO:0032914]; positive regulation of Wnt signaling pathway [GO:0030177]; proton transmembrane transport [GO:1902600]; regulation of MAPK cascade [GO:0043408]; rostrocaudal neural tube patterning [GO:0021903]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29127204}; Single-pass type I membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:29127204}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q9CYN9}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q9CYN9}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q9CYN9}. Endosome membrane {ECO:0000250|UniProtKB:Q9CYN9}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q6AXS4}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q6AXS4}; Single-pass type I membrane protein {ECO:0000305}.
O75791	reviewed	GRAP2_HUMAN	GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)	GRAP2 GADS GRB2L GRID	Homo sapiens (Human)	330	FUNCTION: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.		cell-cell signaling [GO:0007267]; Ras protein signal transduction [GO:0007265]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	phosphotyrosine residue binding [GO:0001784]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; phosphotyrosine residue binding [GO:0001784]; cell-cell signaling [GO:0007267]; Ras protein signal transduction [GO:0007265]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21179510}. Cytoplasm {ECO:0000269|PubMed:21179510}. Endosome {ECO:0000269|PubMed:21179510}.
O75792	reviewed	RNH2A_HUMAN	Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A)	RNASEH2A RNASEHI RNHIA	Homo sapiens (Human)	299	FUNCTION: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}.		DNA replication [GO:0006260]; DNA replication, removal of RNA primer [GO:0043137]; mismatch repair [GO:0006298]; RNA catabolic process [GO:0006401]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ribonuclease H2 complex [GO:0032299]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; RNA-DNA hybrid ribonuclease activity [GO:0004523]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ribonuclease H2 complex [GO:0032299]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; DNA replication [GO:0006260]; DNA replication, removal of RNA primer [GO:0043137]; mismatch repair [GO:0006298]; RNA catabolic process [GO:0006401]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O75795	reviewed	UDB17_HUMAN	UDP-glucuronosyltransferase 2B17 (UDPGT 2B17) (UGT2B17) (EC 2.4.1.17) (C19-steroid-specific UDP-glucuronosyltransferase) (C19-steroid-specific UDPGT)	UGT2B17	Homo sapiens (Human)	530	FUNCTION: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:8798464, PubMed:16595710, PubMed:18719240, PubMed:19022937, PubMed:23288867). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol) (PubMed:8798464, PubMed:16595710, PubMed:18719240, PubMed:19022937, PubMed:23288867). {ECO:0000269|PubMed:16595710, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19022937, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:8798464}.		cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	glucuronosyltransferase activity [GO:0015020]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; glucuronosyltransferase activity [GO:0015020]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:23288867}; Single-pass membrane protein {ECO:0000255}.
O75800	reviewed	ZMY10_HUMAN	Zinc finger MYND domain-containing protein 10 (Protein BLu)	ZMYND10 BLU LUCA12.4	Homo sapiens (Human)	440	FUNCTION: Plays a role in axonemal structure organization and motility (PubMed:23891469, PubMed:23891471). Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity). May act by indirectly regulating transcription of dynein proteins (By similarity). {ECO:0000250|UniProtKB:Q99ML0, ECO:0000269|PubMed:23891469, ECO:0000269|PubMed:23891471}.		cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; positive regulation of motile cilium assembly [GO:1905505]; protein localization to cilium [GO:0061512]	apical plasma membrane [GO:0016324]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293]	metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein folding chaperone [GO:0044183]	apical plasma membrane [GO:0016324]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein folding chaperone [GO:0044183]; cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; positive regulation of motile cilium assembly [GO:1905505]; protein localization to cilium [GO:0061512]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6AXZ5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q6AXZ5}. Apical cell membrane {ECO:0000250|UniProtKB:Q99ML0}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q5FWU8}.
O75807	reviewed	PR15A_HUMAN	Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog)	PPP1R15A GADD34	Homo sapiens (Human)	674	FUNCTION: Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress (PubMed:26742780, PubMed:26095357). Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1 (PubMed:14718519). May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15' (PubMed:14635196). Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). Acts also a viral restriction factor by attenuating HIV-1 replication (PubMed:31778897). Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation (PubMed:31778897). {ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:26095357, ECO:0000269|PubMed:31778897, ECO:0000269|PubMed:8139541}.; FUNCTION: (Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'-UTR. {ECO:0000269|PubMed:34985336}.	MISCELLANEOUS: The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.	apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation [GO:1903917]; positive regulation of peptidyl-serine dephosphorylation [GO:1902310]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of translational initiation in response to stress [GO:0032058]; protein localization to endoplasmic reticulum [GO:0070972]; regulation of cell cycle [GO:0051726]; regulation of translational initiation by eIF2 alpha dephosphorylation [GO:0036496]; response to endoplasmic reticulum stress [GO:0034976]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein phosphatase type 1 complex [GO:0000164]	protein kinase binding [GO:0019901]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein phosphatase type 1 complex [GO:0000164]; protein kinase binding [GO:0019901]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]; apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation [GO:1903917]; positive regulation of peptidyl-serine dephosphorylation [GO:1902310]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of translational initiation in response to stress [GO:0032058]; protein localization to endoplasmic reticulum [GO:0070972]; regulation of cell cycle [GO:0051726]; regulation of translational initiation by eIF2 alpha dephosphorylation [GO:0036496]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:21518769, ECO:0000269|PubMed:26742780}. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:21518769}. Note=Associates with membranes via an N-terminal amphipathic intramembrane region. {ECO:0000269|PubMed:21518769}.
O75808	reviewed	CAN15_HUMAN	Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog)	CAPN15 SOLH	Homo sapiens (Human)	1086			proteolysis [GO:0006508]	cytoplasm [GO:0005737]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; metal ion binding [GO:0046872]; proteolysis [GO:0006508]	
O75815	reviewed	BCAR3_HUMAN	Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)	BCAR3 NSP2 SH2D3B UNQ271/PRO308	Homo sapiens (Human)	825	FUNCTION: Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}.	MISCELLANEOUS: Overexpression confers anti-estrogen resistance via RRAS-independent activation of the PI3K pathway, and activation of the cyclin D1 promoter in breast cancer cell lines (PubMed:9582273). Plays a role in insulin-mediated ERK activation and DNA synthesis in breast cancer cells (PubMed:24216110). {ECO:0000269|PubMed:24216110, ECO:0000269|PubMed:9582273}.	endothelin receptor signaling pathway [GO:0086100]; insulin receptor signaling pathway [GO:0008286]; lens morphogenesis in camera-type eye [GO:0002089]; positive regulation of DNA replication [GO:0045740]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; membrane [GO:0016020]	guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; phosphotyrosine residue binding [GO:0001784]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; membrane [GO:0016020]; guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; phosphotyrosine residue binding [GO:0001784]; endothelin receptor signaling pathway [GO:0086100]; insulin receptor signaling pathway [GO:0008286]; lens morphogenesis in camera-type eye [GO:0002089]; positive regulation of DNA replication [GO:0045740]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QZK2}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q9QZK2}. Note=Localization to focal adhesions depends on interaction with PTPRA. {ECO:0000250|UniProtKB:Q9QZK2}.
O75817	reviewed	POP7_HUMAN	Ribonuclease P protein subunit p20 (RNaseP protein p20) (Ribonucleases P/MRP protein subunit POP7 homolog) (hPOP7)	POP7 RPP20	Homo sapiens (Human)	140	FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9630247, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9630247}.		rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]; tRNA processing [GO:0008033]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]	ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]; ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723]; rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]; tRNA processing [GO:0008033]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:14715275, ECO:0000269|PubMed:20215441}. Cytoplasm {ECO:0000269|PubMed:14715275}. Cytoplasmic granule {ECO:0000269|PubMed:14715275}. Note=Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules. {ECO:0000269|PubMed:14715275}.
O75818	reviewed	RPP40_HUMAN	Ribonuclease P protein subunit p40 (RNaseP protein p40) (RNase P subunit 1)	RPP40 RNASEP1	Homo sapiens (Human)	363	FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9630247, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9630247}.		endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; tRNA 5'-leader removal [GO:0001682]	multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]	ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]	multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]; ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; tRNA 5'-leader removal [GO:0001682]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305}.
O75821	reviewed	EIF3G_HUMAN	Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44)	EIF3G EIF3S4	Homo sapiens (Human)	320	FUNCTION: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.		formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; perinuclear region of cytoplasm [GO:0048471]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; perinuclear region of cytoplasm [GO:0048471]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17094969}. Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17094969}. Note=Colocalizes with AIFM1 in the nucleus and perinuclear region.
O75822	reviewed	EIF3J_HUMAN	Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35)	EIF3J EIF3S1 PRO0391	Homo sapiens (Human)	258	FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.		formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]	identical protein binding [GO:0042802]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; identical protein binding [GO:0042802]; translation initiation factor activity [GO:0003743]; formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03009}.
O75828	reviewed	CBR3_HUMAN	Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 21C member 2)	CBR3 SDR21C2	Homo sapiens (Human)	277	FUNCTION: Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841). Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin (PubMed:18493841, PubMed:15537833, PubMed:19841672). Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19841672). Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified (PubMed:19841672). {ECO:0000269|PubMed:15537833, ECO:0000269|PubMed:18493841, ECO:0000269|PubMed:19841672}.		cognition [GO:0050890]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]	carbonyl reductase (NADPH) activity [GO:0004090]; NADPH binding [GO:0070402]; NADPH dehydrogenase (quinone) activity [GO:0008753]	cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH binding [GO:0070402]; NADPH dehydrogenase (quinone) activity [GO:0008753]; cognition [GO:0050890]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18493841}.
O75829	reviewed	CNMD_HUMAN	Leukocyte cell-derived chemotaxin 1 (Chondromodulin) [Cleaved into: Chondrosurfactant protein (CH-SP); Chondromodulin-1 (Chondromodulin-I) (ChM-I)]	CNMD CHMI LECT1 MYETS1	Homo sapiens (Human)	334	FUNCTION: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. {ECO:0000269|PubMed:16980969}.		cartilage development [GO:0051216]; cell differentiation [GO:0030154]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; proteoglycan metabolic process [GO:0006029]; skeletal system development [GO:0001501]	endomembrane system [GO:0012505]; extracellular region [GO:0005576]; membrane [GO:0016020]		endomembrane system [GO:0012505]; extracellular region [GO:0005576]; membrane [GO:0016020]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; proteoglycan metabolic process [GO:0006029]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: [Chondromodulin-1]: Secreted, extracellular space, extracellular matrix. Note=Accumulated in the inter-territorial matrix of cartilage.; SUBCELLULAR LOCATION: [Chondrosurfactant protein]: Endomembrane system {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
O75832	reviewed	PSD10_HUMAN	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK))	PSMD10	Homo sapiens (Human)	226	FUNCTION: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.; FUNCTION: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.		apoptotic process [GO:0006915]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; proteasome regulatory particle assembly [GO:0070682]; protein localization to plasma membrane [GO:0072659]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]	cytoskeletal protein binding [GO:0008092]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription factor binding [GO:0008134]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; cytoskeletal protein binding [GO:0008092]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription factor binding [GO:0008134]; transmembrane transporter binding [GO:0044325]; apoptotic process [GO:0006915]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; proteasome regulatory particle assembly [GO:0070682]; protein localization to plasma membrane [GO:0072659]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18040287}. Nucleus {ECO:0000269|PubMed:18040287}.
O75838	reviewed	CIB2_HUMAN	Calcium and integrin-binding family member 2 (Kinase-interacting protein 2) (KIP 2)	CIB2 KIP2	Homo sapiens (Human)	187	FUNCTION: Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis (By similarity). Acts as a auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells (By similarity). Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing (By similarity). Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells (By similarity). Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (By similarity). Critical for proper photoreceptor cell maintenance and function (By similarity). Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release (PubMed:23023331, PubMed:26173970, PubMed:26426422). {ECO:0000250|UniProtKB:Q9Z309, ECO:0000269|PubMed:23023331, ECO:0000269|PubMed:26173970, ECO:0000269|PubMed:26426422}.	MISCELLANEOUS: The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form) (PubMed:22779914). {ECO:0000269|PubMed:22779914}.	calcium ion homeostasis [GO:0055074]; cellular response to ATP [GO:0071318]; photoreceptor cell maintenance [GO:0045494]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	blood microparticle [GO:0072562]; cell periphery [GO:0071944]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; muscle tendon junction [GO:0005927]; neuromuscular junction [GO:0031594]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; sarcolemma [GO:0042383]; stereocilium [GO:0032420]	calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]	blood microparticle [GO:0072562]; cell periphery [GO:0071944]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; muscle tendon junction [GO:0005927]; neuromuscular junction [GO:0031594]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; sarcolemma [GO:0042383]; stereocilium [GO:0032420]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; calcium ion homeostasis [GO:0055074]; cellular response to ATP [GO:0071318]; photoreceptor cell maintenance [GO:0045494]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z309}. Cell projection, stereocilium {ECO:0000269|PubMed:26173970, ECO:0000269|PubMed:26426422}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9Z309}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9Z309}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q9Z309}. Note=Colocalizes with ITGA7 at the myotendinous junctions (MTJ) and at the neuromuscular junctions (NMJ) (By similarity). Located mainly in stereocilia and at the apical surface of hair cells of the cochlea (By similarity). Localizes in the cuticular plate along and at the tip of the stereocilia of vestibular sensory hair cells (PubMed:26173970, PubMed:26426422). {ECO:0000250|UniProtKB:Q9Z309, ECO:0000269|PubMed:26173970, ECO:0000269|PubMed:26426422}.
O75840	reviewed	KLF7_HUMAN	Krueppel-like factor 7 (Ubiquitous krueppel-like factor)	KLF7 UKLF	Homo sapiens (Human)	302	FUNCTION: Transcriptional factor (PubMed:9774444, PubMed:16339272). Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation (PubMed:28916725). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272). Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272). {ECO:0000250|UniProtKB:Q99JB0, ECO:0000269|PubMed:16339272, ECO:0000269|PubMed:28916725, ECO:0000269|PubMed:9774444}.		axon guidance [GO:0007411]; axonogenesis [GO:0007409]; dendrite morphogenesis [GO:0048813]; glucose homeostasis [GO:0042593]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epidermal cell differentiation [GO:0045604]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; dendrite morphogenesis [GO:0048813]; glucose homeostasis [GO:0042593]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epidermal cell differentiation [GO:0045604]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9774444}.
O75841	reviewed	UPK1B_HUMAN	Uroplakin-1b (UP1b) (Tetraspanin-20) (Tspan-20) (Uroplakin Ib) (UPIb)	UPK1B TSPAN20	Homo sapiens (Human)	260	FUNCTION: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity). {ECO:0000250}.		epithelial cell differentiation [GO:0030855]; response to bacterium [GO:0009617]	apical plasma membrane urothelial plaque [GO:0120001]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	structural molecule activity [GO:0005198]	apical plasma membrane urothelial plaque [GO:0120001]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
O75843	reviewed	AP1G2_HUMAN	AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad)	AP1G2	Homo sapiens (Human)	785	FUNCTION: May function in protein sorting in late endosomes or multivesucular bodies (MVBs). {ECO:0000269|PubMed:9733768}.; FUNCTION: (Microbial infection) Involved in MVB-assisted maturation of hepatitis B virus (HBV). {ECO:0000269|PubMed:16867982, ECO:0000269|PubMed:17553870}.		Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	AP-1 adaptor complex [GO:0030121]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; membrane [GO:0016020]; transport vesicle [GO:0030133]	clathrin adaptor activity [GO:0035615]	AP-1 adaptor complex [GO:0030121]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; membrane [GO:0016020]; transport vesicle [GO:0030133]; clathrin adaptor activity [GO:0035615]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11333915, ECO:0000269|PubMed:9762922}; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:11333915}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9733768}; Peripheral membrane protein. Endosome membrane {ECO:0000269|PubMed:16867982}; Peripheral membrane protein. Note=Mainly localized to perinuclear vesicular structures (PubMed:9733768). Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments (PubMed:16867982). Colocalizes with HBV major surface antigen L to cis-Golgi-like structures (PubMed:11333915).
O75844	reviewed	FACE1_HUMAN	CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Prenyl protein-specific endoprotease 1) (Zinc metalloproteinase Ste24 homolog)	ZMPSTE24 FACE1 STE24	Homo sapiens (Human)	475	FUNCTION: Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum (PubMed:33315887, PubMed:33293369). Proteolytically removes the C-terminal three residues of farnesylated proteins (PubMed:33315887, PubMed:33293369). Plays also an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia (PubMed:28246125, PubMed:28169297). Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity (PubMed:35283811). {ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:28246125, ECO:0000269|PubMed:33293369, ECO:0000269|PubMed:33315887, ECO:0000269|PubMed:35283811}.		adult walking behavior [GO:0007628]; bone mineralization [GO:0030282]; CAAX-box protein processing [GO:0071586]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; CAMKK-AMPK signaling cascade [GO:0061762]; cardiac conduction [GO:0061337]; cardiac muscle cell development [GO:0055013]; cardiac ventricle development [GO:0003231]; cellular lipid metabolic process [GO:0044255]; cellular response to gamma radiation [GO:0071480]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; growth plate cartilage development [GO:0003417]; hair follicle development [GO:0001942]; heart morphogenesis [GO:0003007]; inflammatory cell apoptotic process [GO:0006925]; kidney morphogenesis [GO:0060993]; liver development [GO:0001889]; maintenance of rDNA [GO:0043007]; multicellular organism growth [GO:0035264]; negative regulation of miRNA processing [GO:1903799]; neuromuscular process [GO:0050905]; nuclear envelope organization [GO:0006998]; positive regulation of gene expression via CpG island demethylation [GO:0044029]; prenylated protein catabolic process [GO:0030327]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]; regulation of bone mineralization [GO:0030500]; regulation of cell shape [GO:0008360]; regulation of cellular senescence [GO:2000772]; regulation of defense response to virus [GO:0050688]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of DNA methylation [GO:0044030]; regulation of fibroblast proliferation [GO:0048145]; regulation of glucose metabolic process [GO:0010906]; regulation of hormone metabolic process [GO:0032350]; regulation of lipid metabolic process [GO:0019216]; regulation of mitotic cell cycle DNA replication [GO:1903463]; regulation of multicellular organism growth [GO:0040014]; regulation of stress-activated protein kinase signaling cascade [GO:0070302]; regulation of termination of RNA polymerase I transcription [GO:2000730]; regulation of TOR signaling [GO:0032006]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to DNA damage checkpoint signaling [GO:0072423]; thymus development [GO:0048538]; ventricular cardiac muscle tissue development [GO:0003229]	early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; protein-containing complex [GO:0032991]	double-stranded DNA binding [GO:0003690]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloexopeptidase activity [GO:0008235]	early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; protein-containing complex [GO:0032991]; double-stranded DNA binding [GO:0003690]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloexopeptidase activity [GO:0008235]; adult walking behavior [GO:0007628]; bone mineralization [GO:0030282]; CAAX-box protein processing [GO:0071586]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; CAMKK-AMPK signaling cascade [GO:0061762]; cardiac conduction [GO:0061337]; cardiac muscle cell development [GO:0055013]; cardiac ventricle development [GO:0003231]; cellular lipid metabolic process [GO:0044255]; cellular response to gamma radiation [GO:0071480]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; growth plate cartilage development [GO:0003417]; hair follicle development [GO:0001942]; heart morphogenesis [GO:0003007]; inflammatory cell apoptotic process [GO:0006925]; kidney morphogenesis [GO:0060993]; liver development [GO:0001889]; maintenance of rDNA [GO:0043007]; multicellular organism growth [GO:0035264]; negative regulation of miRNA processing [GO:1903799]; neuromuscular process [GO:0050905]; nuclear envelope organization [GO:0006998]; positive regulation of gene expression via CpG island demethylation [GO:0044029]; prenylated protein catabolic process [GO:0030327]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]; regulation of bone mineralization [GO:0030500]; regulation of cell shape [GO:0008360]; regulation of cellular senescence [GO:2000772]; regulation of defense response to virus [GO:0050688]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of DNA methylation [GO:0044030]; regulation of fibroblast proliferation [GO:0048145]; regulation of glucose metabolic process [GO:0010906]; regulation of hormone metabolic process [GO:0032350]; regulation of lipid metabolic process [GO:0019216]; regulation of mitotic cell cycle DNA replication [GO:1903463]; regulation of multicellular organism growth [GO:0040014]; regulation of stress-activated protein kinase signaling cascade [GO:0070302]; regulation of termination of RNA polymerase I transcription [GO:2000730]; regulation of TOR signaling [GO:0032006]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to DNA damage checkpoint signaling [GO:0072423]; thymus development [GO:0048538]; ventricular cardiac muscle tissue development [GO:0003229]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23539603}; Multi-pass membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000269|PubMed:23539603}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:35283811}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:35283811}; Multi-pass membrane protein {ECO:0000255}.
O75845	reviewed	SC5D_HUMAN	Lathosterol oxidase (EC 1.14.19.20) (C-5 sterol desaturase) (Delta(7)-sterol 5-desaturase) (Delta(7)-sterol C5(6)-desaturase) (Lathosterol 5-desaturase) (Sterol-C5-desaturase)	SC5D SC5DL	Homo sapiens (Human)	299	FUNCTION: Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol in cholesterol biosynthesis. {ECO:0000269|PubMed:10786622}.		cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; lipid metabolic process [GO:0006629]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	C-5 sterol desaturase activity [GO:0000248]; delta7-sterol 5(6)-desaturase activity [GO:0050046]; iron ion binding [GO:0005506]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; C-5 sterol desaturase activity [GO:0000248]; delta7-sterol 5(6)-desaturase activity [GO:0050046]; iron ion binding [GO:0005506]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O75864	reviewed	PPR37_HUMAN	Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68)	PPP1R37 KIAA1986 LRRC68	Homo sapiens (Human)	691	FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.	MISCELLANEOUS: [Isoform 2]: Due to an intron retention. {ECO:0000305}.			protein phosphatase inhibitor activity [GO:0004864]	protein phosphatase inhibitor activity [GO:0004864]	
O75865	reviewed	TPC6A_HUMAN	Trafficking protein particle complex subunit 6A (TRAPP complex subunit 6A)	TRAPPC6A HSPC289	Homo sapiens (Human)	159	FUNCTION: May play a role in vesicular transport during the biogenesis of melanosomes. {ECO:0000250|UniProtKB:Q78XR0}.		COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle tethering [GO:0099022]	cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; trans-Golgi network [GO:0005802]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072]		cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; trans-Golgi network [GO:0005802]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
O75871	reviewed	CEAM4_HUMAN	Carcinoembryonic antigen-related cell adhesion molecule 4 (CEA cell adhesion molecule 4) (Carcinoembryonic antigen CGM7) (Non-specific cross-reacting antigen W236)	CEACAM4 CGM7	Homo sapiens (Human)	244	FUNCTION: Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles. {ECO:0000269|PubMed:25567962}.	MISCELLANEOUS: To study the function of the orphan receptor CEACAM4 chimeric proteins containing the extracellular bacteria-binding domain of CEACAM3 and the transmembrane and cytoplasmic part of CEACAM4 has been used. {ECO:0000305|PubMed:25567962}.	phagocytosis [GO:0006909]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]	protein tyrosine kinase binding [GO:1990782]	cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein tyrosine kinase binding [GO:1990782]; phagocytosis [GO:0006909]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
O75874	reviewed	IDHC_HUMAN	Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)	IDH1 PICD	Homo sapiens (Human)	414	FUNCTION: Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity). {ECO:0000250|UniProtKB:Q9XSG3, ECO:0000269|PubMed:10521434, ECO:0000269|PubMed:19935646, ECO:0000303|PubMed:10521434}.		2-oxoglutarate metabolic process [GO:0006103]; female gonad development [GO:0008585]; glutathione metabolic process [GO:0006749]; glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; NADP metabolic process [GO:0006739]; regulation of phospholipid biosynthetic process [GO:0071071]; regulation of phospholipid catabolic process [GO:0060696]; response to oxidative stress [GO:0006979]; response to steroid hormone [GO:0048545]; tricarboxylic acid cycle [GO:0006099]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; 2-oxoglutarate metabolic process [GO:0006103]; female gonad development [GO:0008585]; glutathione metabolic process [GO:0006749]; glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; NADP metabolic process [GO:0006739]; regulation of phospholipid biosynthetic process [GO:0071071]; regulation of phospholipid catabolic process [GO:0060696]; response to oxidative stress [GO:0006979]; response to steroid hormone [GO:0048545]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10521434}. Peroxisome {ECO:0000269|PubMed:10521434}.
O75879	reviewed	GATB_HUMAN	Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112 homolog)	GATB PET112 PET112L HSPC199	Homo sapiens (Human)	557	FUNCTION: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03147, ECO:0000269|PubMed:19805282}.		glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543]	glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567]	glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567]; glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03147, ECO:0000269|PubMed:9878253}.
O75880	reviewed	SCO1_HUMAN	Protein SCO1 homolog, mitochondrial	SCO1 SCOD1	Homo sapiens (Human)	301	FUNCTION: Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478, PubMed:15229189). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity). {ECO:0000250|UniProtKB:Q5SUC9, ECO:0000269|PubMed:15229189, ECO:0000269|PubMed:15659396, ECO:0000269|PubMed:16735468, ECO:0000269|PubMed:17189203, ECO:0000269|PubMed:19336478}.		intracellular copper ion homeostasis [GO:0006878]; mitochondrial cytochrome c oxidase assembly [GO:0033617]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; myofibril [GO:0030016]	copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; myofibril [GO:0030016]; copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]; intracellular copper ion homeostasis [GO:0006878]; mitochondrial cytochrome c oxidase assembly [GO:0033617]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:9878253}. Mitochondrion inner membrane {ECO:0000269|PubMed:15229189}; Single-pass membrane protein {ECO:0000255}.
O75881	reviewed	CP7B1_HUMAN	Cytochrome P450 7B1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (25/26-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.29) (3-hydroxysteroid 7-alpha hydroxylase) (Oxysterol 7-alpha-hydroxylase)	CYP7B1	Homo sapiens (Human)	506	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids (PubMed:10588945, PubMed:24491228). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10588945, PubMed:24491228). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position (PubMed:10588945, PubMed:24491228). Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy steroid 7-alpha hydroxylase (PubMed:24491228). Hydroxylates oxysterols, including 25-hydroxycholesterol and (25R)-cholest-5-ene-3beta,26-diol toward 7-alpha hydroxy derivatives, which may be transported to the liver and converted to bile acids (PubMed:9802883, PubMed:10588945). Via its product 7-alpha,25-dihydroxycholesterol, a ligand for the chemotactic G protein-coupled receptor GPR183/EBI2, regulates B cell migration in germinal centers of lymphoid organs, thus guiding efficient maturation of plasma B cells and overall antigen-specific humoral immune response (By similarity). 7-alpha hydroxylates neurosteroids, including 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone) and pregnenolone, both involved in hippocampus-associated memory and learning (PubMed:24491228). Metabolizes androstanoids toward 6- or 7-alpha hydroxy derivatives (PubMed:24491228). {ECO:0000250|UniProtKB:Q60991, ECO:0000269|PubMed:10588945, ECO:0000269|PubMed:24491228, ECO:0000269|PubMed:9802883}.		B cell chemotaxis [GO:0035754]; bile acid biosynthetic process [GO:0006699]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; epithelial cell proliferation [GO:0050673]; intracellular estrogen receptor signaling pathway [GO:0030520]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; positive regulation of epithelial cell proliferation [GO:0050679]; prostate gland epithelium morphogenesis [GO:0060740]; sterol metabolic process [GO:0016125]	endoplasmic reticulum membrane [GO:0005789]	24-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033782]; 25-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033783]; 27-hydroxycholesterol 7-alpha-monooxygenase activity [GO:0047092]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxysterol 7-alpha-hydroxylase activity [GO:0008396]	endoplasmic reticulum membrane [GO:0005789]; 24-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033782]; 25-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033783]; 27-hydroxycholesterol 7-alpha-monooxygenase activity [GO:0047092]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxysterol 7-alpha-hydroxylase activity [GO:0008396]; B cell chemotaxis [GO:0035754]; bile acid biosynthetic process [GO:0006699]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; epithelial cell proliferation [GO:0050673]; intracellular estrogen receptor signaling pathway [GO:0030520]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; positive regulation of epithelial cell proliferation [GO:0050679]; prostate gland epithelium morphogenesis [GO:0060740]; sterol metabolic process [GO:0016125]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:9802883}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305|PubMed:9802883}; Multi-pass membrane protein {ECO:0000305}.
O75882	reviewed	ATRN_HUMAN	Attractin (DPPT-L) (Mahogany homolog)	ATRN KIAA0548 MGCA	Homo sapiens (Human)	1429	FUNCTION: Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). {ECO:0000250, ECO:0000269|PubMed:9736737}.		cerebellum development [GO:0021549]; inflammatory response [GO:0006954]; myelination [GO:0042552]; pigmentation [GO:0043473]; regulation of multicellular organism growth [GO:0040014]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023]; cerebellum development [GO:0021549]; inflammatory response [GO:0006954]; myelination [GO:0042552]; pigmentation [GO:0043473]; regulation of multicellular organism growth [GO:0040014]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:7539799}; Single-pass type I membrane protein {ECO:0000269|PubMed:7539799}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:7539799, ECO:0000269|PubMed:9736737}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:7539799}.
O75884	reviewed	RBBP9_HUMAN	Serine hydrolase RBBP9 (EC 3.-.-.-) (B5T-overexpressed gene protein) (Protein BOG) (Retinoblastoma-binding protein 10) (RBBP-10) (Retinoblastoma-binding protein 9) (RBBP-9)	RBBP9 BOG RBBP10	Homo sapiens (Human)	186	FUNCTION: Serine hydrolase whose substrates have not been identified yet (PubMed:19329999, PubMed:20080647). May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (PubMed:20080647). May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699). {ECO:0000269|PubMed:19329999, ECO:0000269|PubMed:20080647, ECO:0000269|PubMed:9697699}.	MISCELLANEOUS: Plays a role in maintaining pluripotency in human stem cells in vitro. {ECO:0000269|PubMed:21689726}.	positive regulation of gene expression [GO:0010628]; response to nematode [GO:0009624]; type II pneumocyte differentiation [GO:0060510]	nucleoplasm [GO:0005654]	hydrolase activity [GO:0016787]	nucleoplasm [GO:0005654]; hydrolase activity [GO:0016787]; positive regulation of gene expression [GO:0010628]; response to nematode [GO:0009624]; type II pneumocyte differentiation [GO:0060510]	
O75886	reviewed	STAM2_HUMAN	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)	STAM2 HBP	Homo sapiens (Human)	525	FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}.		macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; ESCRT-0 complex [GO:0033565]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; ESCRT-0 complex [GO:0033565]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:12551915}; Peripheral membrane protein {ECO:0000269|PubMed:12551915}; Cytoplasmic side {ECO:0000269|PubMed:12551915}.
O75888	reviewed	TNF13_HUMAN	Tumor necrosis factor ligand superfamily member 13 (A proliferation-inducing ligand) (APRIL) (TNF- and APOL-related leukocyte expressed ligand 2) (TALL-2) (TNF-related death ligand 1) (TRDL-1) (CD antigen CD256)	TNFSF13 APRIL TALL2 ZTNF2 UNQ383/PRO715	Homo sapiens (Human)	250	FUNCTION: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. {ECO:0000269|PubMed:10973284}.		immune response [GO:0006955]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	cytokine activity [GO:0005125]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; cytokine activity [GO:0005125]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; immune response [GO:0006955]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11571266}.
O75891	reviewed	AL1L1_HUMAN	Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1)	ALDH1L1 FTHFD	Homo sapiens (Human)	902	FUNCTION: Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:19933275, PubMed:21238436). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity). {ECO:0000250|UniProtKB:P28037, ECO:0000269|PubMed:19933275, ECO:0000269|PubMed:21238436}.		10-formyltetrahydrofolate catabolic process [GO:0009258]; biosynthetic process [GO:0009058]; NADPH regeneration [GO:0006740]; one-carbon metabolic process [GO:0006730]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	aldehyde dehydrogenase (NAD+) activity [GO:0004029]; formyltetrahydrofolate dehydrogenase activity [GO:0016155]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; formyltetrahydrofolate dehydrogenase activity [GO:0016155]; 10-formyltetrahydrofolate catabolic process [GO:0009258]; biosynthetic process [GO:0009058]; NADPH regeneration [GO:0006740]; one-carbon metabolic process [GO:0006730]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:19933275}.
O75896	reviewed	TUSC2_HUMAN	Tumor suppressor candidate 2 (Fusion 1 protein) (Fus-1 protein) (PDGFA-associated protein 2)	TUSC2 C3orf11 FUS1 LGCC PDAP2	Homo sapiens (Human)	110	FUNCTION: May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.		cell cycle [GO:0007049]; cell maturation [GO:0048469]; inflammatory response [GO:0006954]; natural killer cell differentiation [GO:0001779]; negative regulation of interleukin-17 production [GO:0032700]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; phagocytosis [GO:0006909]; positive regulation of interleukin-10 production [GO:0032733]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; cell cycle [GO:0007049]; cell maturation [GO:0048469]; inflammatory response [GO:0006954]; natural killer cell differentiation [GO:0001779]; negative regulation of interleukin-17 production [GO:0032700]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; phagocytosis [GO:0006909]; positive regulation of interleukin-10 production [GO:0032733]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377]	
O75897	reviewed	ST1C4_HUMAN	Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2)	SULT1C4 SULT1C2	Homo sapiens (Human)	302	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2) (PubMed:17425406, PubMed:28222028, PubMed:9852044, PubMed:26948952). Mediates the sulfation of doxorubicin and its analog epirubicin, two antitumor anthracyclines (PubMed:26948952). {ECO:0000269|PubMed:17425406, ECO:0000269|PubMed:26948952, ECO:0000269|PubMed:28222028, ECO:0000269|PubMed:9852044}.		3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; doxorubicin metabolic process [GO:0044598]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; doxorubicin metabolic process [GO:0044598]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:28222028}.
O75899	reviewed	GABR2_HUMAN	Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20)	GABBR2 GPR51 GPRC3B	Homo sapiens (Human)	941	FUNCTION: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). {ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:10328880, ECO:0000269|PubMed:15617512, ECO:0000269|PubMed:18165688, ECO:0000269|PubMed:22660477, ECO:0000269|PubMed:24305054, ECO:0000269|PubMed:9872316, ECO:0000269|PubMed:9872744, ECO:0000305}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of adenylate cyclase activity [GO:0007194]; neuron-glial cell signaling [GO:0150099]; synaptic transmission, GABAergic [GO:0051932]	cytoplasm [GO:0005737]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA receptor complex [GO:1902710]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	G protein-coupled GABA receptor activity [GO:0004965]; protein heterodimerization activity [GO:0046982]; transmembrane signaling receptor activity [GO:0004888]	cytoplasm [GO:0005737]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA receptor complex [GO:1902710]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; G protein-coupled GABA receptor activity [GO:0004965]; protein heterodimerization activity [GO:0046982]; transmembrane signaling receptor activity [GO:0004888]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of adenylate cyclase activity [GO:0007194]; neuron-glial cell signaling [GO:0150099]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10328880, ECO:0000269|PubMed:15617512, ECO:0000269|PubMed:9872316}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:O88871}; Multi-pass membrane protein {ECO:0000305}. Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane. {ECO:0000269|PubMed:15617512}.
O75900	reviewed	MMP23_HUMAN	Matrix metalloproteinase-23 (MMP-23) (EC 3.4.24.-) (Femalysin) (MIFR-1) (Matrix metalloproteinase-21) (MMP-21) (Matrix metalloproteinase-22) (MMP-22) [Cleaved into: Matrix metalloproteinase-23, soluble form]	MMP23B MMP21 MMP22	Homo sapiens (Human)	390	FUNCTION: Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity). {ECO:0000250}.		collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]; reproduction [GO:0000003]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]; reproduction [GO:0000003]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Membrane {ECO:0000269|PubMed:11328856}; Single-pass type II membrane protein {ECO:0000269|PubMed:11328856}. Note=A secreted form produced by proteolytic cleavage may also exist. {ECO:0000305}.
O75907	reviewed	DGAT1_HUMAN	Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase)	DGAT1 AGRP1 DGAT	Homo sapiens (Human)	488	FUNCTION: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:9756920, PubMed:32433611, PubMed:32433610). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (PubMed:18768481). In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:16214399). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (PubMed:18768481). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:16214399). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000250|UniProtKB:Q8MK44, ECO:0000250|UniProtKB:Q9Z2A7, ECO:0000269|PubMed:16214399, ECO:0000269|PubMed:18768481, ECO:0000269|PubMed:28420705, ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0000269|PubMed:9756920}.		diacylglycerol metabolic process [GO:0046339]; fatty acid homeostasis [GO:0055089]; lipid storage [GO:0019915]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; monoacylglycerol biosynthetic process [GO:0006640]; triglyceride biosynthetic process [GO:0019432]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle assembly [GO:0034379]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	2-acylglycerol O-acyltransferase activity [GO:0003846]; acyltransferase activity [GO:0016746]; diacylglycerol O-acyltransferase activity [GO:0004144]; identical protein binding [GO:0042802]; retinol O-fatty-acyltransferase activity [GO:0050252]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; 2-acylglycerol O-acyltransferase activity [GO:0003846]; acyltransferase activity [GO:0016746]; diacylglycerol O-acyltransferase activity [GO:0004144]; identical protein binding [GO:0042802]; retinol O-fatty-acyltransferase activity [GO:0050252]; diacylglycerol metabolic process [GO:0046339]; fatty acid homeostasis [GO:0055089]; lipid storage [GO:0019915]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; monoacylglycerol biosynthetic process [GO:0006640]; triglyceride biosynthetic process [GO:0019432]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle assembly [GO:0034379]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z2A7}; Multi-pass membrane protein {ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611}.
O75908	reviewed	SOAT2_HUMAN	Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2)	SOAT2 ACACT2 ACAT2	Homo sapiens (Human)	522	FUNCTION: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16647063, PubMed:11294643). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:11294643). Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates (PubMed:11294643). May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa (PubMed:11294643). {ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:16647063}.; FUNCTION: [Isoform 2]: Has lower enzymatic activity compared to isoform 1. {ECO:0000269|PubMed:16331323}.; FUNCTION: [Isoform 3]: Has lower enzymatic activity compared to isoform 1. {ECO:0000269|PubMed:16331323}.		cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; intestinal cholesterol absorption [GO:0030299]; low-density lipoprotein particle clearance [GO:0034383]; macrophage derived foam cell differentiation [GO:0010742]; very-low-density lipoprotein particle assembly [GO:0034379]	brush border [GO:0005903]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	acyltransferase activity [GO:0016746]; cholesterol binding [GO:0015485]; cholesterol O-acyltransferase activity [GO:0034736]; fatty-acyl-CoA binding [GO:0000062]; sterol O-acyltransferase activity [GO:0004772]	brush border [GO:0005903]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; acyltransferase activity [GO:0016746]; cholesterol binding [GO:0015485]; cholesterol O-acyltransferase activity [GO:0034736]; fatty-acyl-CoA binding [GO:0000062]; sterol O-acyltransferase activity [GO:0004772]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; intestinal cholesterol absorption [GO:0030299]; low-density lipoprotein particle clearance [GO:0034383]; macrophage derived foam cell differentiation [GO:0010742]; very-low-density lipoprotein particle assembly [GO:0034379]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O88908}; Multi-pass membrane protein {ECO:0000255}.
O75909	reviewed	CCNK_HUMAN	Cyclin-K	CCNK CPR4	Homo sapiens (Human)	580	FUNCTION: Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). {ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:9632813}.		cell cycle [GO:0007049]; cell division [GO:0051301]; DNA damage response [GO:0006974]; negative regulation by host of viral genome replication [GO:0044828]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of signal transduction [GO:0009966]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	cyclin K-CDK12 complex [GO:0002944]; cyclin K-CDK13 complex [GO:0002945]; cyclin/CDK positive transcription elongation factor complex [GO:0008024]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase binding [GO:0019901]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]	cyclin K-CDK12 complex [GO:0002944]; cyclin K-CDK13 complex [GO:0002945]; cyclin/CDK positive transcription elongation factor complex [GO:0008024]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase binding [GO:0019901]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; cell cycle [GO:0007049]; cell division [GO:0051301]; DNA damage response [GO:0006974]; negative regulation by host of viral genome replication [GO:0044828]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of signal transduction [GO:0009966]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22012619}.
O75911	reviewed	DHRS3_HUMAN	Short-chain dehydrogenase/reductase 3 (EC 1.1.1.300) (DD83.1) (Retinal short-chain dehydrogenase/reductase 1) (retSDR1) (Retinol dehydrogenase 17) (Short chain dehydrogenase/reductase family 16C member 1)	DHRS3 RDH17 SDR16C1 UNQ2424/PRO4983	Homo sapiens (Human)	302	FUNCTION: Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH. {ECO:0000269|PubMed:9705317}.	MISCELLANEOUS: Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors.	bone morphogenesis [GO:0060349]; cardiac septum morphogenesis [GO:0060411]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; outflow tract morphogenesis [GO:0003151]; regulation of ossification [GO:0030278]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; roof of mouth development [GO:0060021]; visual perception [GO:0007601]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; photoreceptor outer segment membrane [GO:0042622]	electron transfer activity [GO:0009055]; NAD-retinol dehydrogenase activity [GO:0004745]; NADP-retinol dehydrogenase activity [GO:0052650]; nucleotide binding [GO:0000166]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; photoreceptor outer segment membrane [GO:0042622]; electron transfer activity [GO:0009055]; NAD-retinol dehydrogenase activity [GO:0004745]; NADP-retinol dehydrogenase activity [GO:0052650]; nucleotide binding [GO:0000166]; bone morphogenesis [GO:0060349]; cardiac septum morphogenesis [GO:0060411]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; outflow tract morphogenesis [GO:0003151]; regulation of ossification [GO:0030278]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; roof of mouth development [GO:0060021]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O75912	reviewed	DGKI_HUMAN	Diacylglycerol kinase iota (DAG kinase iota) (DGK-iota) (EC 2.7.1.107)	DGKI	Homo sapiens (Human)	1065	FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9830018, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:9830018). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity). {ECO:0000250|UniProtKB:D3YWQ0, ECO:0000269|PubMed:23949095, ECO:0000269|PubMed:9830018, ECO:0000305}.		diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of synaptic transmission, glutamatergic [GO:0051966]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; synaptic vesicle membrane [GO:0030672]	ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; synaptic vesicle membrane [GO:0030672]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872]; diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of synaptic transmission, glutamatergic [GO:0051966]	SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000250|UniProtKB:F1MAB7}. Cell projection, dendrite {ECO:0000250|UniProtKB:F1MAB7}. Presynapse {ECO:0000250|UniProtKB:F1MAB7}. Postsynapse {ECO:0000250|UniProtKB:F1MAB7}. Postsynaptic density {ECO:0000250|UniProtKB:F1MAB7}. Synaptic cell membrane {ECO:0000250|UniProtKB:F1MAB7}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:F1MAB7}. Cytoplasm, cytosol {ECO:0000269|PubMed:9830018}. Nucleus {ECO:0000269|PubMed:9830018}. Note=Excluded from inhibitory synapses (By similarity). Localization between cytoplasm and nucleus is regulated by protein kinase C (PubMed:9830018). Both in the detergent soluble and particulate fractions (By similarity). {ECO:0000250|UniProtKB:F1MAB7, ECO:0000269|PubMed:9830018}.
O75914	reviewed	PAK3_HUMAN	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3)	PAK3 OPHN3	Homo sapiens (Human)	559	FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}.		axonogenesis [GO:0007409]; cellular response to organic cyclic compound [GO:0071407]; dendrite development [GO:0016358]; dendritic spine morphogenesis [GO:0060997]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of axonogenesis [GO:0050770]; regulation of MAPK cascade [GO:0043408]; regulation of postsynapse organization [GO:0099175]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; synapse organization [GO:0050808]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]; axonogenesis [GO:0007409]; cellular response to organic cyclic compound [GO:0071407]; dendrite development [GO:0016358]; dendritic spine morphogenesis [GO:0060997]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of axonogenesis [GO:0050770]; regulation of MAPK cascade [GO:0043408]; regulation of postsynapse organization [GO:0099175]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O75915	reviewed	PRAF3_HUMAN	PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Cytoskeleton-related vitamin A-responsive protein) (Dermal papilla-derived protein 11) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (JM5) (Prenylated Rab acceptor protein 2) (Protein JWa) (Putative MAPK-activating protein PM27)	ARL6IP5 DERP11 JWA PRA2 PRAF3 HSPC127	Homo sapiens (Human)	188	FUNCTION: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q8R5J9, ECO:0000250|UniProtKB:Q9ES40}.		cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; glutathione metabolic process [GO:0006749]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; learning or memory [GO:0007611]; negative regulation of L-glutamate import across plasma membrane [GO:0002037]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of transport [GO:0051051]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]	cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic cytosol [GO:0099523]		cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic cytosol [GO:0099523]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; glutathione metabolic process [GO:0006749]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; learning or memory [GO:0007611]; negative regulation of L-glutamate import across plasma membrane [GO:0002037]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of transport [GO:0051051]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ES40}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9ES40}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9ES40}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9ES40}. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules. {ECO:0000250|UniProtKB:Q9ES40}.
O75916	reviewed	RGS9_HUMAN	Regulator of G-protein signaling 9 (RGS9)	RGS9	Homo sapiens (Human)	674	FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity). {ECO:0000250}.		dark adaptation [GO:1990603]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; light adaption [GO:0036367]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; dark adaptation [GO:1990603]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; light adaption [GO:0036367]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: [Isoform 3]: Membrane; Peripheral membrane protein. Note=Isoform 3 is targeted to the membrane via its interaction with RGS9BP. {ECO:0000250}.
O75920	reviewed	SERF1_HUMAN	Small EDRK-rich factor 1 (Protein 4F5) (h4F5) (SMA modifier 1)	SERF1A FAM2A SERF1 SMAM1; SERF1B FAM2B SERF1 SMAM1	Homo sapiens (Human)	110	FUNCTION: Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760, PubMed:22854022, PubMed:31034892). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (PubMed:20723760, PubMed:22854022, PubMed:31034892). {ECO:0000269|PubMed:20723760, ECO:0000269|PubMed:22854022, ECO:0000269|PubMed:31034892}.		amyloid fibril formation [GO:1990000]; nervous system development [GO:0007399]; protein destabilization [GO:0031648]	cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]		cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; amyloid fibril formation [GO:1990000]; nervous system development [GO:0007399]; protein destabilization [GO:0031648]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:31034892}. Nucleus {ECO:0000269|PubMed:31034892}.
O75923	reviewed	DYSF_HUMAN	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1)	DYSF FER1L1	Homo sapiens (Human)	2080	FUNCTION: Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 14]: Produced by alternative promoter usage. {ECO:0000305}.	macrophage activation involved in immune response [GO:0002281]; monocyte activation involved in immune response [GO:0002280]; negative regulation of phagocytosis [GO:0050765]; regulation of neurotransmitter secretion [GO:0046928]	centriolar satellite [GO:0034451]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; synaptic vesicle membrane [GO:0030672]; T-tubule [GO:0030315]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phospholipid binding [GO:0005543]	centriolar satellite [GO:0034451]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; synaptic vesicle membrane [GO:0030672]; T-tubule [GO:0030315]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phospholipid binding [GO:0005543]; macrophage activation involved in immune response [GO:0002281]; monocyte activation involved in immune response [GO:0002280]; negative regulation of phagocytosis [GO:0050765]; regulation of neurotransmitter secretion [GO:0046928]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane. Note=Colocalizes, during muscle differentiation, with BIN1 in the T-tubule system of myotubules and at the site of contact between two myotubes or a myoblast and a myotube. Wounding of myotubes led to its focal enrichment to the site of injury and to its relocalization in a Ca(2+)-dependent manner toward the plasma membrane. Colocalizes with AHNAK, AHNAK2 and PARVB at the sarcolemma of skeletal muscle. Detected on the apical plasma membrane of the syncytiotrophoblast. Reaches the plasmma membrane through a caveolin-independent mechanism. Retained by caveolin at the plasmma membrane (By similarity). Colocalizes, during muscle differentiation, with CACNA1S in the T-tubule system of myotubules (By similarity). Accumulates and colocalizes with fusion vesicles at the sarcolemma disruption sites (By similarity). {ECO:0000250}.
O75925	reviewed	PIAS1_HUMAN	E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)	PIAS1 DDXBP1	Homo sapiens (Human)	651	FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumolyation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:21965678}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}.		fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of smooth muscle cell differentiation [GO:0051152]; protein sumoylation [GO:0016925]; protein-DNA complex assembly [GO:0065004]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; visual learning [GO:0008542]	nuclear periphery [GO:0034399]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	nuclear periphery [GO:0034399]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of smooth muscle cell differentiation [GO:0051152]; protein sumoylation [GO:0016925]; protein-DNA complex assembly [GO:0065004]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O88907}. Nucleus speckle {ECO:0000269|PubMed:12393906, ECO:0000269|PubMed:9177271}. Nucleus, PML body {ECO:0000250|UniProtKB:O88907}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11672422}. Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton (PubMed:11672422). Interaction with MSX1 is required for localization to the nuclear periphery (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11672422}.
O75928	reviewed	PIAS2_HUMAN	E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)	PIAS2 PIASX	Homo sapiens (Human)	621	FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'. {ECO:0000269|PubMed:15920481, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:22406621}.		DNA-templated transcription [GO:0006351]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; protein sumoylation [GO:0016925]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	DNA binding [GO:0003677]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; DNA binding [GO:0003677]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; DNA-templated transcription [GO:0006351]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; protein sumoylation [GO:0016925]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q8C5D8}. Nucleus, PML body {ECO:0000269|PubMed:12716907, ECO:0000269|PubMed:22406621}. Nucleus {ECO:0000269|PubMed:11477070, ECO:0000269|PubMed:12393906}. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:22406621). Colocalizes with SUMO1 in nuclear granules (By similarity). {ECO:0000250|UniProtKB:Q8C5D8, ECO:0000269|PubMed:22406621}.
O75934	reviewed	SPF27_HUMAN	Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27)	BCAS2 DAM1	Homo sapiens (Human)	225	FUNCTION: Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). {ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30705154}.		mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	catalytic step 2 spliceosome [GO:0071013]; centrosome [GO:0005813]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]		catalytic step 2 spliceosome [GO:0071013]; centrosome [GO:0005813]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12169396, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30705154}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
O75935	reviewed	DCTN3_HUMAN	Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit) (p22)	DCTN3 DCTN22	Homo sapiens (Human)	186	FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis (PubMed:9722614). {ECO:0000250|UniProtKB:F1SEC0, ECO:0000269|PubMed:9722614}.		cytoskeleton-dependent cytokinesis [GO:0061640]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]	structural molecule activity [GO:0005198]	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]; structural molecule activity [GO:0005198]; cytoskeleton-dependent cytokinesis [GO:0061640]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9722614}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:9722614}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:9722614}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9722614}. Cleavage furrow {ECO:0000269|PubMed:9722614}. Midbody {ECO:0000269|PubMed:9722614}. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.
O75936	reviewed	BODG_HUMAN	Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase)	BBOX1 BBH BBOX	Homo sapiens (Human)	387	FUNCTION: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.		carnitine biosynthetic process [GO:0045329]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	gamma-butyrobetaine dioxygenase activity [GO:0008336]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; gamma-butyrobetaine dioxygenase activity [GO:0008336]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; zinc ion binding [GO:0008270]; carnitine biosynthetic process [GO:0045329]	SUBCELLULAR LOCATION: Cytoplasm.
O75937	reviewed	DNJC8_HUMAN	DnaJ homolog subfamily C member 8 (Splicing protein spf31)	DNAJC8 SPF31 HSPC315 HSPC331	Homo sapiens (Human)	253	FUNCTION: Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716). {ECO:0000269|PubMed:27133716}.			cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	Hsp70 protein binding [GO:0030544]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Hsp70 protein binding [GO:0030544]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27133716}.
O75940	reviewed	SPF30_HUMAN	Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1)	SMNDC1 SMNR SPF30	Homo sapiens (Human)	238	FUNCTION: Involved in spliceosome assembly. {ECO:0000269|PubMed:11331295, ECO:0000269|PubMed:11331595, ECO:0000269|PubMed:9817934}.		apoptotic process [GO:0006915]; mRNA processing [GO:0006397]; RNA splicing, via transesterification reactions [GO:0000375]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; mRNA processing [GO:0006397]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11331295, ECO:0000269|PubMed:9817934}. Nucleus, Cajal body {ECO:0000269|PubMed:11331295}. Note=Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies. {ECO:0000269|PubMed:11331295}.
O75943	reviewed	RAD17_HUMAN	Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog)	RAD17 R24L	Homo sapiens (Human)	681	FUNCTION: Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603}.		DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; negative regulation of DNA replication [GO:0008156]; regulation of phosphorylation [GO:0042325]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad17 RFC-like complex [GO:0031389]	ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA clamp loader activity [GO:0003689]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad17 RFC-like complex [GO:0031389]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA clamp loader activity [GO:0003689]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; negative regulation of DNA replication [GO:0008156]; regulation of phosphorylation [GO:0042325]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10232579, ECO:0000269|PubMed:10593953, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12400013}. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
O75951	reviewed	LYZL6_HUMAN	Lysozyme-like protein 6 (EC 3.2.1.17)	LYZL6 LYC1 UNQ754/PRO1485	Homo sapiens (Human)	148	FUNCTION: May be involved sperm-egg plasma membrane adhesion and fusion during fertilization (PubMed:28182716). Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus (PubMed:28182716, PubMed:24013621). Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH (PubMed:28182716). Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (PubMed:28182716). {ECO:0000269|PubMed:24013621, ECO:0000269|PubMed:28182716}.		defense response to bacterium [GO:0042742]; fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; killing of cells of another organism [GO:0031640]; metabolic process [GO:0008152]	acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; extracellular region [GO:0005576]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm plasma membrane [GO:0097524]	lysozyme activity [GO:0003796]	acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; extracellular region [GO:0005576]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm plasma membrane [GO:0097524]; lysozyme activity [GO:0003796]; defense response to bacterium [GO:0042742]; fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; killing of cells of another organism [GO:0031640]; metabolic process [GO:0008152]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28182716}. Cell surface {ECO:0000269|PubMed:28182716}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9DA11}. Note=Detected on the postacrosomal membrane of mature spermatozoa (PubMed:28182716). {ECO:0000269|PubMed:28182716}.
O75952	reviewed	CABYR_HUMAN	Calcium-binding tyrosine phosphorylation-regulated protein (Calcium-binding protein 86) (Cancer/testis antigen 88) (CT88) (Fibrousheathin II) (Fibrousheathin-2) (FSP-2) (Testis-specific calcium-binding protein CBP86)	CABYR CBP86 FSP2	Homo sapiens (Human)	493	FUNCTION: May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; sperm capacitation [GO:0048240]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]	calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; SH3 domain binding [GO:0017124]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
O75955	reviewed	FLOT1_HUMAN	Flotillin-1	FLOT1	Homo sapiens (Human)	427	FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.		axonogenesis [GO:0007409]; cellular response to exogenous dsRNA [GO:0071360]; dsRNA transport [GO:0033227]; extracellular matrix disassembly [GO:0022617]; plasma membrane raft assembly [GO:0044854]; plasma membrane raft organization [GO:0044857]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of cytokine production [GO:0001819]; positive regulation of endocytosis [GO:0045807]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; protein kinase C signaling [GO:0070528]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of neurotransmitter uptake [GO:0051580]; regulation of receptor internalization [GO:0002090]; regulation of Rho protein signal transduction [GO:0035023]; response to endoplasmic reticulum stress [GO:0034976]	adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasmic vesicle [GO:0031410]; dopaminergic synapse [GO:0098691]; early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; sarcolemma [GO:0042383]; uropod [GO:0001931]	ionotropic glutamate receptor binding [GO:0035255]; protease binding [GO:0002020]	adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasmic vesicle [GO:0031410]; dopaminergic synapse [GO:0098691]; early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; sarcolemma [GO:0042383]; uropod [GO:0001931]; ionotropic glutamate receptor binding [GO:0035255]; protease binding [GO:0002020]; axonogenesis [GO:0007409]; cellular response to exogenous dsRNA [GO:0071360]; dsRNA transport [GO:0033227]; extracellular matrix disassembly [GO:0022617]; plasma membrane raft assembly [GO:0044854]; plasma membrane raft organization [GO:0044857]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of cytokine production [GO:0001819]; positive regulation of endocytosis [GO:0045807]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; protein kinase C signaling [GO:0070528]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of neurotransmitter uptake [GO:0051580]; regulation of receptor internalization [GO:0002090]; regulation of Rho protein signal transduction [GO:0035023]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Endosome {ECO:0000269|PubMed:20682791}. Membrane, caveola {ECO:0000250|UniProtKB:O08917}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08917}. Melanosome {ECO:0000269|PubMed:17081065}. Membrane raft {ECO:0000269|PubMed:25893292}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Membrane-associated protein of caveola (By similarity). {ECO:0000250|UniProtKB:O08917, ECO:0000269|PubMed:17081065}.
O75956	reviewed	CDKA2_HUMAN	Cyclin-dependent kinase 2-associated protein 2 (CDK2-associated protein 2) (DOC-1-related protein) (DOC-1R)	CDK2AP2 DOC1R	Homo sapiens (Human)	126	FUNCTION: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:33283408). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148). Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (By similarity). Regulates microtubule organization of metaphase II oocytes (By similarity). {ECO:0000250|UniProtKB:Q9CPY4, ECO:0000269|PubMed:23781148, ECO:0000269|PubMed:33283408}.		negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of stem cell division [GO:2000035]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; NuRD complex [GO:0016581]		cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of stem cell division [GO:2000035]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10082655}. Nucleus {ECO:0000269|PubMed:10082655, ECO:0000269|PubMed:33283408}. Note=Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules. {ECO:0000250|UniProtKB:Q9CPY4}.
O75962	reviewed	TRIO_HUMAN	Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)	TRIO	Homo sapiens (Human)	3097	FUNCTION: Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:22155786, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}.		axon guidance [GO:0007411]; negative regulation of fat cell differentiation [GO:0045599]; neuron projection morphogenesis [GO:0048812]; phosphorylation [GO:0016310]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of small GTPase mediated signal transduction [GO:0051056]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; presynaptic active zone [GO:0048786]	ATP binding [GO:0005524]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; presynaptic active zone [GO:0048786]; ATP binding [GO:0005524]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; axon guidance [GO:0007411]; negative regulation of fat cell differentiation [GO:0045599]; neuron projection morphogenesis [GO:0048812]; phosphorylation [GO:0016310]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of small GTPase mediated signal transduction [GO:0051056]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:22155786}. Cell projection {ECO:0000250|UniProtKB:Q0KL02}.
O75969	reviewed	AKAP3_HUMAN	A-kinase anchor protein 3 (AKAP-3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Cancer/testis antigen 82) (CT82) (Fibrous sheath protein of 95 kDa) (FSP95) (Fibrousheathin I) (Fibrousheathin-1) (Protein kinase A-anchoring protein 3) (PRKA3) (Sperm oocyte-binding protein)	AKAP3 AKAP110 SOB1	Homo sapiens (Human)	853	FUNCTION: May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.		acrosome reaction [GO:0007340]; blastocyst hatching [GO:0001835]; protein localization [GO:0008104]; single fertilization [GO:0007338]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	protein kinase A binding [GO:0051018]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; protein kinase A binding [GO:0051018]; acrosome reaction [GO:0007340]; blastocyst hatching [GO:0001835]; protein localization [GO:0008104]; single fertilization [GO:0007338]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.
O75970	reviewed	MPDZ_HUMAN	Multiple PDZ domain protein (Multi-PDZ domain protein 1)	MPDZ MUPP1	Homo sapiens (Human)	2070	FUNCTION: Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}.		microtubule organizing center organization [GO:0031023]; regulation of microtubule cytoskeleton organization [GO:0070507]; tight junction assembly [GO:0120192]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]		apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; microtubule organizing center organization [GO:0031023]; regulation of microtubule cytoskeleton organization [GO:0070507]; tight junction assembly [GO:0120192]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Synapse. Synapse, synaptosome. Note=Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells (By similarity). Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. {ECO:0000250, ECO:0000250|UniProtKB:O55164}.
O75971	reviewed	SNPC5_HUMAN	snRNA-activating protein complex subunit 5 (SNAPc subunit 5) (Small nuclear RNA-activating complex polypeptide 5) (snRNA-activating protein complex 19 kDa subunit) (SNAPc 19 kDa subunit)	SNAPC5 SNAP19	Homo sapiens (Human)	98	FUNCTION: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.		snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; transcription initiation at RNA polymerase III promoter [GO:0006384]	nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995]	nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; transcription initiation at RNA polymerase III promoter [GO:0006384]	SUBCELLULAR LOCATION: Nucleus.
O75976	reviewed	CBPD_HUMAN	Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)	CPD	Homo sapiens (Human)	1380			peptide metabolic process [GO:0006518]; protein processing [GO:0016485]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]	metallocarboxypeptidase activity [GO:0004181]; serine-type carboxypeptidase activity [GO:0004185]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; metallocarboxypeptidase activity [GO:0004181]; serine-type carboxypeptidase activity [GO:0004185]; zinc ion binding [GO:0008270]; peptide metabolic process [GO:0006518]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q90240}; Single-pass type I membrane protein {ECO:0000255}.
O75995	reviewed	SASH3_HUMAN	SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog)	SASH3 CXorf9 SLY	Homo sapiens (Human)	380	FUNCTION: May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}.		B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; homeostasis of number of cells within a tissue [GO:0048873]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of organ growth [GO:0046622]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; T cell proliferation [GO:0042098]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; homeostasis of number of cells within a tissue [GO:0048873]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of organ growth [GO:0046622]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; T cell proliferation [GO:0042098]	
O76003	reviewed	GLRX3_HUMAN	Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)	GLRX3 PICOT TXNL2 HUSSY-22	Homo sapiens (Human)	335	FUNCTION: Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250|UniProtKB:Q9CQM9, ECO:0000269|PubMed:23615448, ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}.	MISCELLANEOUS: Silencing of Grx3 in HeLa cells decreases the activities of several cytosolic Fe/S proteins, such as ACO1, a major component of post-transcriptional iron regulation. As a consequence, Grx3-depleted cells show decreased levels of ferritin and increased levels of transferrin receptor, features characteristic of cellular iron starvation (PubMed:23615448). {ECO:0000305|PubMed:23615448}.	[2Fe-2S] cluster assembly [GO:0044571]; cell redox homeostasis [GO:0045454]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; regulation of the force of heart contraction [GO:0002026]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; iron-sulfur cluster assembly complex [GO:1990229]; nucleus [GO:0005634]; Z disc [GO:0030018]	identical protein binding [GO:0042802]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; iron-sulfur cluster assembly complex [GO:1990229]; nucleus [GO:0005634]; Z disc [GO:0030018]; identical protein binding [GO:0042802]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; [2Fe-2S] cluster assembly [GO:0044571]; cell redox homeostasis [GO:0045454]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; regulation of the force of heart contraction [GO:0002026]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:27519415}. Cytoplasm, cell cortex {ECO:0000269|PubMed:10636891}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9CQM9}. Note=Under the plasma membrane (By similarity). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250|UniProtKB:Q9CQM9}.
O76011	reviewed	KRT34_HUMAN	Keratin, type I cuticular Ha4 (Hair keratin, type I Ha4) (Keratin-34) (K34)	KRT34 HHA4 HKA4 KRTHA4	Homo sapiens (Human)	394		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
O76013	reviewed	KRT36_HUMAN	Keratin, type I cuticular Ha6 (Hair keratin, type I Ha6) (Keratin-36) (K36)	KRT36 HHA6 HKA6 KRTHA6	Homo sapiens (Human)	467		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; regulation of keratinocyte differentiation [GO:0045616]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; regulation of keratinocyte differentiation [GO:0045616]	
O76014	reviewed	KRT37_HUMAN	Keratin, type I cuticular Ha7 (Hair keratin, type I Ha7) (Keratin-37) (K37)	KRT37 HHA7 HKA7 KRTHA7	Homo sapiens (Human)	449		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
O76015	reviewed	KRT38_HUMAN	Keratin, type I cuticular Ha8 (Hair keratin, type I Ha8) (Keratin-38) (K38)	KRT38 HHA8 HKA8 KRTHA8	Homo sapiens (Human)	456		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
O76021	reviewed	RL1D1_HUMAN	Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)	RSL1D1 CATX11 CSIG PBK1 L12	Homo sapiens (Human)	490	FUNCTION: Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}.		maturation of LSU-rRNA [GO:0000470]; osteoblast differentiation [GO:0001649]; regulation of apoptotic process [GO:0042981]; regulation of cellular senescence [GO:2000772]; regulation of protein localization [GO:0032880]	90S preribosome [GO:0030686]; chromosome [GO:0005694]; cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; nucleolus [GO:0005730]	cadherin binding [GO:0045296]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]	90S preribosome [GO:0030686]; chromosome [GO:0005694]; cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; nucleolus [GO:0005730]; cadherin binding [GO:0045296]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; maturation of LSU-rRNA [GO:0000470]; osteoblast differentiation [GO:0001649]; regulation of apoptotic process [GO:0042981]; regulation of cellular senescence [GO:2000772]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. Note=Colocalizes with ING1 in the nucleolus after UV stress. {ECO:0000269|PubMed:22419112}.
O76024	reviewed	WFS1_HUMAN	Wolframin	WFS1	Homo sapiens (Human)	890	FUNCTION: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (PubMed:16989814). Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism (PubMed:23035048). {ECO:0000269|PubMed:16989814, ECO:0000269|PubMed:23035048}.		calcium ion homeostasis [GO:0055074]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; glucose homeostasis [GO:0042593]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ATF6-mediated unfolded protein response [GO:1903892]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of programmed cell death [GO:0043069]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; nervous system process [GO:0050877]; olfactory behavior [GO:0042048]; pancreas development [GO:0031016]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of growth [GO:0045927]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein ubiquitination [GO:0031398]; protein maturation by protein folding [GO:0022417]; protein stabilization [GO:0050821]; renal water homeostasis [GO:0003091]; response to endoplasmic reticulum stress [GO:0034976]; sensory perception of sound [GO:0007605]; ubiquitin-dependent ERAD pathway [GO:0030433]; visual perception [GO:0007601]	dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672]	ATPase binding [GO:0051117]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; DNA-binding transcription factor binding [GO:0140297]; proteasome binding [GO:0070628]; ubiquitin protein ligase binding [GO:0031625]	dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672]; ATPase binding [GO:0051117]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; DNA-binding transcription factor binding [GO:0140297]; proteasome binding [GO:0070628]; ubiquitin protein ligase binding [GO:0031625]; calcium ion homeostasis [GO:0055074]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; glucose homeostasis [GO:0042593]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ATF6-mediated unfolded protein response [GO:1903892]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of programmed cell death [GO:0043069]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; nervous system process [GO:0050877]; olfactory behavior [GO:0042048]; pancreas development [GO:0031016]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of growth [GO:0045927]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein ubiquitination [GO:0031398]; protein maturation by protein folding [GO:0022417]; protein stabilization [GO:0050821]; renal water homeostasis [GO:0003091]; response to endoplasmic reticulum stress [GO:0034976]; sensory perception of sound [GO:0007605]; ubiquitin-dependent ERAD pathway [GO:0030433]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:23035048}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:23035048}. Note=Co-localizes with ATP6V1A in the secretory granules in neuroblastoma cell lines. {ECO:0000269|PubMed:23035048}.
O76027	reviewed	ANXA9_HUMAN	Annexin A9 (Annexin XXXI) (Annexin-31) (Annexin-9) (Pemphaxin)	ANXA9 ANX31	Homo sapiens (Human)	345	FUNCTION: Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes. {ECO:0000269|PubMed:10899159}.		cell-cell adhesion [GO:0098609]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; vesicle [GO:0031982]	acetylcholine receptor activity [GO:0015464]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; phospholipase A2 inhibitor activity [GO:0019834]; phospholipid binding [GO:0005543]; protease binding [GO:0002020]; virion binding [GO:0046790]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; vesicle [GO:0031982]; acetylcholine receptor activity [GO:0015464]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; phospholipase A2 inhibitor activity [GO:0019834]; phospholipid binding [GO:0005543]; protease binding [GO:0002020]; virion binding [GO:0046790]; cell-cell adhesion [GO:0098609]	
O76031	reviewed	CLPX_HUMAN	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial	CLPX	Homo sapiens (Human)	633	FUNCTION: ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP (PubMed:28874591). Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (PubMed:28874591). Important for efficient erythropoiesis through up-regulation of heme biosynthesis (PubMed:25957689, PubMed:28874591). {ECO:0000269|PubMed:11923310, ECO:0000269|PubMed:22710082, ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:25957689, ECO:0000269|PubMed:28874591}.		ATP metabolic process [GO:0046034]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]	cytosol [GO:0005829]; endopeptidase Clp complex [GO:0009368]; mitochondrial endopeptidase Clp complex [GO:0009841]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; peptidase activator activity [GO:0016504]; protein dimerization activity [GO:0046983]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; endopeptidase Clp complex [GO:0009368]; mitochondrial endopeptidase Clp complex [GO:0009841]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; peptidase activator activity [GO:0016504]; protein dimerization activity [GO:0046983]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]; ATP metabolic process [GO:0046034]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.
O76036	reviewed	NCTR1_HUMAN	Natural cytotoxicity triggering receptor 1 (Lymphocyte antigen 94 homolog) (NK cell-activating receptor) (Natural killer cell p46-related protein) (NK-p46) (NKp46) (hNKp46) (CD antigen CD335)	NCR1 LY94	Homo sapiens (Human)	304	FUNCTION: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. {ECO:0000269|PubMed:9730896}.		cellular defense response [GO:0006968]; natural killer cell activation [GO:0030101]; regulation of natural killer cell mediated cytotoxicity [GO:0042269]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]; SWI/SNF complex [GO:0016514]		plasma membrane [GO:0005886]; SWI/SNF complex [GO:0016514]; cellular defense response [GO:0006968]; natural killer cell activation [GO:0030101]; regulation of natural killer cell mediated cytotoxicity [GO:0042269]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O76039	reviewed	CDKL5_HUMAN	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9)	CDKL5 STK9	Homo sapiens (Human)	960	FUNCTION: Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860, ECO:0000269|PubMed:29420175}.		modulation of chemical synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of GTPase activity [GO:0043547]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cilium assembly [GO:1902017]; regulation of dendrite development [GO:0050773]; regulation of postsynapse organization [GO:0099175]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; dendrite cytoplasm [GO:0032839]; dendritic growth cone [GO:0044294]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density, intracellular component [GO:0099092]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; dendrite cytoplasm [GO:0032839]; dendritic growth cone [GO:0044294]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density, intracellular component [GO:0099092]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]; modulation of chemical synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of GTPase activity [GO:0043547]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cilium assembly [GO:1902017]; regulation of dendrite development [GO:0050773]; regulation of postsynapse organization [GO:0099175]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16935860}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:29420175}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29420175}.
O76041	reviewed	NEBL_HUMAN	Nebulette (Actin-binding Z-disk protein)	NEBL C10orf113 LNEBL	Homo sapiens (Human)	1014	FUNCTION: Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623). Isoform 2 might play a role in the assembly of focal adhesion (PubMed:15004028). {ECO:0000269|PubMed:15004028, ECO:0000269|PubMed:27733623}.	MISCELLANEOUS: [Isoform 2]: Expressed in non-muscle cells. May be transcribed from an upstream promoter active in non-muscle cells. {ECO:0000305}.	cardiac muscle thin filament assembly [GO:0071691]	extracellular exosome [GO:0070062]; I band [GO:0031674]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; cytoskeletal protein binding [GO:0008092]; filamin binding [GO:0031005]; structural constituent of muscle [GO:0008307]; tropomyosin binding [GO:0005523]	extracellular exosome [GO:0070062]; I band [GO:0031674]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; cytoskeletal protein binding [GO:0008092]; filamin binding [GO:0031005]; structural constituent of muscle [GO:0008307]; tropomyosin binding [GO:0005523]; cardiac muscle thin filament assembly [GO:0071691]	SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15004028}.
O76050	reviewed	NEUL1_HUMAN	E3 ubiquitin-protein ligase NEURL1 (EC 2.3.2.27) (Neuralized-like protein 1A) (h-neu) (h-neuralized 1) (RING finger protein 67) (RING-type E3 ubiquitin transferase NEURL1)	NEURL1 NEURL NEURL1A RNF67	Homo sapiens (Human)	574	FUNCTION: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. {ECO:0000269|PubMed:20847082}.		cellular response to amino acid stimulus [GO:0071230]; lactation [GO:0007595]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of Notch signaling pathway [GO:0045746]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; positive regulation of apoptotic process [GO:0043065]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of synapse maturation [GO:0090129]; protein monoubiquitination [GO:0006513]; skeletal muscle tissue development [GO:0007519]; sperm axoneme assembly [GO:0007288]	apical dendrite [GO:0097440]; dendritic spine [GO:0043197]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	metal ion binding [GO:0046872]; translation factor activity, non-nucleic acid binding [GO:0045183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	apical dendrite [GO:0097440]; dendritic spine [GO:0043197]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; metal ion binding [GO:0046872]; translation factor activity, non-nucleic acid binding [GO:0045183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to amino acid stimulus [GO:0071230]; lactation [GO:0007595]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of Notch signaling pathway [GO:0045746]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; positive regulation of apoptotic process [GO:0043065]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of synapse maturation [GO:0090129]; protein monoubiquitination [GO:0006513]; skeletal muscle tissue development [GO:0007519]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:20847082}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Postsynaptic density {ECO:0000250}. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface. {ECO:0000250}.
O76054	reviewed	S14L2_HUMAN	SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (hTAP) (Squalene transfer protein) (Supernatant protein factor) (SPF)	SEC14L2 C22orf6 KIAA1186 KIAA1658	Homo sapiens (Human)	403	FUNCTION: Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.		positive regulation of DNA-templated transcription [GO:0045893]; regulation of cholesterol biosynthetic process [GO:0045540]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	phospholipid binding [GO:0005543]; vitamin E binding [GO:0008431]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phospholipid binding [GO:0005543]; vitamin E binding [GO:0008431]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cholesterol biosynthetic process [GO:0045540]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.
O76061	reviewed	STC2_HUMAN	Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP)	STC2	Homo sapiens (Human)	302	FUNCTION: Has an anti-hypocalcemic action on calcium and phosphate homeostasis.		cellular response to hypoxia [GO:0071456]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; endoplasmic reticulum unfolded protein response [GO:0030968]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; regulation of hormone biosynthetic process [GO:0046885]; regulation of store-operated calcium entry [GO:2001256]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434]; response to vitamin D [GO:0033280]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]	enzyme binding [GO:0019899]; heme binding [GO:0020037]; hormone activity [GO:0005179]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; hormone activity [GO:0005179]; protein homodimerization activity [GO:0042803]; cellular response to hypoxia [GO:0071456]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; endoplasmic reticulum unfolded protein response [GO:0030968]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; regulation of hormone biosynthetic process [GO:0046885]; regulation of store-operated calcium entry [GO:2001256]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434]; response to vitamin D [GO:0033280]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O76062	reviewed	ERG24_HUMAN	Delta(14)-sterol reductase TM7SF2 (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (Another new gene 1 protein) (C-14 sterol reductase) (C14SR) (Putative sterol reductase SR-1) (Sterol C14-reductase) (Transmembrane 7 superfamily member 2)	TM7SF2 ANG1	Homo sapiens (Human)	418	FUNCTION: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. {ECO:0000269|PubMed:16784888}.		cholesterol biosynthetic process [GO:0006695]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	delta14-sterol reductase activity [GO:0050613]; NADP binding [GO:0050661]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; delta14-sterol reductase activity [GO:0050613]; NADP binding [GO:0050661]; cholesterol biosynthetic process [GO:0006695]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:Q71KT5}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:9878250}; Multi-pass membrane protein {ECO:0000255}.
O76064	reviewed	RNF8_HUMAN	E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)	RNF8 KIAA0646	Homo sapiens (Human)	485	FUNCTION: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites (PubMed:11322894, PubMed:14981089, PubMed:17724460, PubMed:18001824, PubMed:18001825, PubMed:18006705, PubMed:18077395, PubMed:18337245, PubMed:18948756, PubMed:19015238, PubMed:19124460, PubMed:19202061, PubMed:19203578, PubMed:19203579, PubMed:20550933, PubMed:21558560, PubMed:21857671, PubMed:21911360, PubMed:22266820, PubMed:22373579, PubMed:22531782, PubMed:22705371, PubMed:22865450, PubMed:22980979). Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity (PubMed:23233665). In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2 (PubMed:11322894, PubMed:14981089, PubMed:17724460, PubMed:18001824, PubMed:18001825, PubMed:18006705, PubMed:18077395, PubMed:18337245, PubMed:18948756, PubMed:19015238, PubMed:19124460, PubMed:19202061, PubMed:19203578, PubMed:19203579, PubMed:20550933, PubMed:21558560, PubMed:21857671, PubMed:21911360, PubMed:22266820, PubMed:22373579, PubMed:22531782, PubMed:22705371, PubMed:22865450, PubMed:22980979). {ECO:0000269|PubMed:11322894, ECO:0000269|PubMed:14981089, ECO:0000269|PubMed:17724460, ECO:0000269|PubMed:18001824, ECO:0000269|PubMed:18001825, ECO:0000269|PubMed:18006705, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:18337245, ECO:0000269|PubMed:18948756, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:20550933, ECO:0000269|PubMed:21558560, ECO:0000269|PubMed:21857671, ECO:0000269|PubMed:21911360, ECO:0000269|PubMed:22266820, ECO:0000269|PubMed:22373579, ECO:0000269|PubMed:22531782, ECO:0000269|PubMed:22705371, ECO:0000269|PubMed:22865450, ECO:0000269|PubMed:22980979, ECO:0000269|PubMed:23233665}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell cycle [GO:0007049]; cell division [GO:0051301]; DNA damage response [GO:0006974]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; epigenetic regulation of gene expression [GO:0040029]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of DNA repair [GO:0045739]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; response to ionizing radiation [GO:0010212]; signal transduction in response to DNA damage [GO:0042770]; sperm DNA condensation [GO:0035092]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; cell division [GO:0051301]; DNA damage response [GO:0006974]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; epigenetic regulation of gene expression [GO:0040029]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of DNA repair [GO:0045739]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; response to ionizing radiation [GO:0010212]; signal transduction in response to DNA damage [GO:0042770]; sperm DNA condensation [GO:0035092]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03067, ECO:0000269|PubMed:11322894, ECO:0000269|PubMed:14981089, ECO:0000269|PubMed:16215985, ECO:0000269|PubMed:23233665}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03067}. Midbody {ECO:0000255|HAMAP-Rule:MF_03067}. Chromosome, telomere {ECO:0000255|HAMAP-Rule:MF_03067}. Note=Recruited at uncapped telomeres (By similarity). Following DNA damage, such as double-strand breaks, recruited to the sites of damage (PubMed:18001824, PubMed:18077395, PubMed:22266820, PubMed:23233665). During prophase, concomitant with nuclear envelope breakdown, localizes throughout the cell, with a dotted pattern. In telophase, again in the nucleus and also with a discrete dotted pattern in the cytoplasm. In late telophase and during cytokinesis, localizes in the midbody of the tubulin bridge joining the daughter cells. Does not seem to be associated with condensed chromosomes at any time during the cell cycle. During spermatogenesis, sequestered in the cytoplasm by PIWIL1: RNF8 is released following ubiquitination and degradation of PIWIL1. {ECO:0000255|HAMAP-Rule:MF_03067, ECO:0000269|PubMed:18001824, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:22266820, ECO:0000269|PubMed:23233665}.
O76070	reviewed	SYUG_HUMAN	Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR)	SNCG BCSG1 PERSYN PRSN	Homo sapiens (Human)	127	FUNCTION: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}.		adult locomotory behavior [GO:0008344]; chemical synaptic transmission [GO:0007268]; protein secretion [GO:0009306]; regulation of dopamine secretion [GO:0014059]; regulation of neurotransmitter secretion [GO:0046928]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488]	axon terminus [GO:0043679]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]	cuprous ion binding [GO:1903136]	axon terminus [GO:0043679]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]; cuprous ion binding [GO:1903136]; adult locomotory behavior [GO:0008344]; chemical synaptic transmission [GO:0007268]; protein secretion [GO:0009306]; regulation of dopamine secretion [GO:0014059]; regulation of neurotransmitter secretion [GO:0046928]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11746666}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11746666}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11746666}. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
O76071	reviewed	CIAO1_HUMAN	Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39)	CIAO1 CIA1 WDR39	Homo sapiens (Human)	339	FUNCTION: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633). {ECO:0000255|HAMAP-Rule:MF_03037, ECO:0000269|PubMed:17937914, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:9556563}.	MISCELLANEOUS: 'Ciao' means 'bridge' in Chinese.	chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]; positive regulation of cell population proliferation [GO:0008284]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; regulation of transcription by RNA polymerase II [GO:0006357]	CIA complex [GO:0097361]; cytoplasm [GO:0005737]; MMXD complex [GO:0071817]		CIA complex [GO:0097361]; cytoplasm [GO:0005737]; MMXD complex [GO:0071817]; chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]; positive regulation of cell population proliferation [GO:0008284]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23585563}.
O76074	reviewed	PDE5A_HUMAN	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE)	PDE5A PDE5	Homo sapiens (Human)	875	FUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334). {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9714779}.		cGMP catabolic process [GO:0046069]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of T cell proliferation [GO:0042130]; oocyte development [GO:0048599]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of oocyte development [GO:0060282]; regulation of nitric oxide mediated signal transduction [GO:0010749]; relaxation of cardiac muscle [GO:0055119]; signal transduction [GO:0007165]; T cell proliferation [GO:0042098]	cytosol [GO:0005829]	3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP binding [GO:0030553]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP binding [GO:0030553]; metal ion binding [GO:0046872]; cGMP catabolic process [GO:0046069]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of T cell proliferation [GO:0042130]; oocyte development [GO:0048599]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of oocyte development [GO:0060282]; regulation of nitric oxide mediated signal transduction [GO:0010749]; relaxation of cardiac muscle [GO:0055119]; signal transduction [GO:0007165]; T cell proliferation [GO:0042098]	
O76075	reviewed	DFFB_HUMAN	DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (Caspase-activated nuclease) (CPAN) (DNA fragmentation factor 40 kDa subunit) (DFF-40)	DFFB CAD DFF2 DFF40	Homo sapiens (Human)	338	FUNCTION: Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.	MISCELLANEOUS: [Isoform Beta]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform Gamma]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform Delta]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	apoptotic chromosome condensation [GO:0030263]; apoptotic DNA fragmentation [GO:0006309]; DNA catabolic process [GO:0006308]; negative regulation of apoptotic DNA fragmentation [GO:1902511]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA nuclease activity [GO:0004536]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA nuclease activity [GO:0004536]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; apoptotic chromosome condensation [GO:0030263]; apoptotic DNA fragmentation [GO:0006309]; DNA catabolic process [GO:0006308]; negative regulation of apoptotic DNA fragmentation [GO:1902511]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
O76076	reviewed	CCN5_HUMAN	CCN family member 5 (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58) (WNT1-inducible-signaling pathway protein 2) (WISP-2)	CCN5 CT58 CTGFL WISP2 UNQ228/PRO261	Homo sapiens (Human)	250	FUNCTION: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.		cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; signal transduction [GO:0007165]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; nucleus [GO:0005634]	heparin binding [GO:0008201]; integrin binding [GO:0005178]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; nucleus [GO:0005634]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O76080	reviewed	ZFAN5_HUMAN	AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216)	ZFAND5 ZA20D2 ZNF216	Homo sapiens (Human)	213	FUNCTION: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}.		face development [GO:0060324]; fibroblast migration [GO:0010761]; in utero embryonic development [GO:0001701]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; respiratory system process [GO:0003016]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745]; vasculature development [GO:0001944]	cytoplasm [GO:0005737]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; face development [GO:0060324]; fibroblast migration [GO:0010761]; in utero embryonic development [GO:0001701]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; respiratory system process [GO:0003016]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745]; vasculature development [GO:0001944]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O76081	reviewed	RGS20_HUMAN	Regulator of G-protein signaling 20 (RGS20) (Gz-selective GTPase-activating protein) (G(z)GAP) (Gz-GAP) (Regulator of G-protein signaling Z1) (Regulator of Gz-selective protein signaling 1)	RGS20 RGSZ1 ZGAP1	Homo sapiens (Human)	388	FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). {ECO:0000250, ECO:0000269|PubMed:12379657}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation. {ECO:0000250}.
O76082	reviewed	S22A5_HUMAN	Organic cation/carnitine transporter 2 (High-affinity sodium-dependent carnitine cotransporter) (Solute carrier family 22 member 5)	SLC22A5 OCTN2	Homo sapiens (Human)	557	FUNCTION: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine (PubMed:10454528, PubMed:10525100, PubMed:10966938, PubMed:17509700, PubMed:20722056, PubMed:33124720). Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 11.3 (PubMed:10454528, PubMed:10525100, PubMed:10966938). In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from Bacillus Subtilis wich induces cytoprotective heat shock proteins contributing to intestinal homeostasis (PubMed:18005709). May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000269|PubMed:10454528, ECO:0000269|PubMed:10525100, ECO:0000269|PubMed:10966938, ECO:0000269|PubMed:17509700, ECO:0000269|PubMed:18005709, ECO:0000269|PubMed:20722056, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 3]: Retained in the ER, unable to perform carnitine uptake. {ECO:0000269|PubMed:17509700}.		(R)-carnitine transmembrane transport [GO:1902270]; (R)-carnitine transport [GO:1900749]; carnitine transmembrane transport [GO:1902603]; carnitine transport [GO:0015879]; positive regulation of intestinal epithelial structure maintenance [GO:0060731]; quaternary ammonium group transport [GO:0015697]; response to symbiotic bacterium [GO:0009609]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; sodium ion transport [GO:0006814]; sodium-dependent organic cation transport [GO:0070715]; transport across blood-brain barrier [GO:0150104]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	(R)-carnitine transmembrane transporter activity [GO:1901235]; amino-acid betaine transmembrane transporter activity [GO:0015199]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; symporter activity [GO:0015293]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; (R)-carnitine transmembrane transporter activity [GO:1901235]; amino-acid betaine transmembrane transporter activity [GO:0015199]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; symporter activity [GO:0015293]; xenobiotic transmembrane transporter activity [GO:0042910]; (R)-carnitine transmembrane transport [GO:1902270]; (R)-carnitine transport [GO:1900749]; carnitine transmembrane transport [GO:1902603]; carnitine transport [GO:0015879]; positive regulation of intestinal epithelial structure maintenance [GO:0060731]; quaternary ammonium group transport [GO:0015697]; response to symbiotic bacterium [GO:0009609]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; sodium ion transport [GO:0006814]; sodium-dependent organic cation transport [GO:0070715]; transport across blood-brain barrier [GO:0150104]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10679939, ECO:0000269|PubMed:17509700, ECO:0000269|PubMed:33334877}; Multi-pass membrane protein {ECO:0000269|PubMed:10679939}. Apical cell membrane {ECO:0000269|PubMed:10966938, ECO:0000269|PubMed:20722056}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000255}. Note=In intestinal cells, apical expression is induced by TNF. Localized to the basal membrane of Sertoli cells (PubMed:35307651). {ECO:0000269|PubMed:20722056, ECO:0000269|PubMed:35307651}.; SUBCELLULAR LOCATION: [Isoform 3]: Endoplasmic reticulum {ECO:0000269|PubMed:17509700}.
O76083	reviewed	PDE9A_HUMAN	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)	PDE9A	Homo sapiens (Human)	593	FUNCTION: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). {ECO:0000250|UniProtKB:Q8QZV1, ECO:0000269|PubMed:18757755, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:25799991, ECO:0000269|PubMed:9624146, ECO:0000305}.	MISCELLANEOUS: PDE9A is a potential target for treatment of diseases such as stress-induced heart disease or long-term memory defects. Specific inhibitors, such as BAY-73-6691 or PF-4449613 are promising candidates for clinical tests. {ECO:0000303|PubMed:24746902, ECO:0000305|PubMed:25799991}.; MISCELLANEOUS: N-(4-methoxyphenyl)-N~2~-[1-(2-methylphenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-L-alaninamide correspond to compound 28. {ECO:0000305|PubMed:22985069}.	cGMP catabolic process [GO:0046069]; cGMP metabolic process [GO:0046068]; negative regulation of neural precursor cell proliferation [GO:2000178]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of long-term synaptic potentiation [GO:1900273]; signal transduction [GO:0007165]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]	3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; cGMP catabolic process [GO:0046069]; cGMP metabolic process [GO:0046068]; negative regulation of neural precursor cell proliferation [GO:2000178]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of long-term synaptic potentiation [GO:1900273]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform PDE9A1]: Cell projection, ruffle membrane {ECO:0000269|PubMed:17090334}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17090334}. Golgi apparatus {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}. Cell membrane, sarcolemma {ECO:0000269|PubMed:25799991}.; SUBCELLULAR LOCATION: [Isoform PDE9A2]: Cell projection, ruffle membrane {ECO:0000269|PubMed:17090334}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17090334}.; SUBCELLULAR LOCATION: [Isoform PDE9A3]: Cytoplasm {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}.; SUBCELLULAR LOCATION: [Isoform PDE9A17]: Cytoplasm {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}.
O76090	reviewed	BEST1_HUMAN	Bestrophin-1 (TU15B) (Vitelliform macular dystrophy protein 2)	BEST1 VMD2	Homo sapiens (Human)	585	FUNCTION: Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. {ECO:0000269|PubMed:11904445, ECO:0000269|PubMed:12907679, ECO:0000269|PubMed:18400985}.		chloride transport [GO:0006821]; detection of light stimulus involved in visual perception [GO:0050908]; monoatomic ion transmembrane transport [GO:0034220]; regulation of calcium ion transport [GO:0051924]; transepithelial chloride transport [GO:0030321]; visual perception [GO:0007601]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; chloride channel complex [GO:0034707]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; intracellular calcium activated chloride channel activity [GO:0005229]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; chloride channel complex [GO:0034707]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; intracellular calcium activated chloride channel activity [GO:0005229]; chloride transport [GO:0006821]; detection of light stimulus involved in visual perception [GO:0050908]; monoatomic ion transmembrane transport [GO:0034220]; regulation of calcium ion transport [GO:0051924]; transepithelial chloride transport [GO:0030321]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19853238, ECO:0000269|PubMed:26200502}; Multi-pass membrane protein {ECO:0000269|PubMed:19853238}. Basolateral cell membrane {ECO:0000269|PubMed:19853238, ECO:0000269|PubMed:26200502}.
O76093	reviewed	FGF18_HUMAN	Fibroblast growth factor 18 (FGF-18) (zFGF5)	FGF18 UNQ420/PRO856	Homo sapiens (Human)	207	FUNCTION: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. {ECO:0000269|PubMed:16597617}.		anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cell-cell signaling [GO:0007267]; chondrocyte development [GO:0002063]; endochondral ossification [GO:0001958]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast growth factor receptor signaling pathway [GO:0008543]; intramembranous ossification [GO:0001957]; lung development [GO:0030324]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleolus [GO:0005730]	growth factor activity [GO:0008083]; type 1 fibroblast growth factor receptor binding [GO:0005105]; type 2 fibroblast growth factor receptor binding [GO:0005111]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; growth factor activity [GO:0008083]; type 1 fibroblast growth factor receptor binding [GO:0005105]; type 2 fibroblast growth factor receptor binding [GO:0005111]; anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cell-cell signaling [GO:0007267]; chondrocyte development [GO:0002063]; endochondral ossification [GO:0001958]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast growth factor receptor signaling pathway [GO:0008543]; intramembranous ossification [GO:0001957]; lung development [GO:0030324]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
O76094	reviewed	SRP72_HUMAN	Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein)	SRP72	Homo sapiens (Human)	671	FUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:27899666, PubMed:21073748). Can bind 7SL RNA with low affinity (PubMed:27899666, PubMed:21073748). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38688, ECO:0000269|PubMed:21073748, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}.		SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]	7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]; TPR domain binding [GO:0030911]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]; TPR domain binding [GO:0030911]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22541560}. Endoplasmic reticulum {ECO:0000269|PubMed:22541560, ECO:0000269|PubMed:28369529}.
O76095	reviewed	JTB_HUMAN	Protein JTB (Jumping translocation breakpoint protein) (Prostate androgen-regulated protein) (PAR protein)	JTB HSPC222	Homo sapiens (Human)	146	FUNCTION: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). {ECO:0000250, ECO:0000269|PubMed:21225229}.		apoptotic mitochondrial changes [GO:0008637]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; positive regulation of protein kinase activity [GO:0045860]; regulation of cell population proliferation [GO:0042127]	cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; spindle [GO:0005819]	protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; spindle [GO:0005819]; protein kinase binding [GO:0019901]; apoptotic mitochondrial changes [GO:0008637]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; positive regulation of protein kinase activity [GO:0045860]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
O76096	reviewed	CYTF_HUMAN	Cystatin-F (Cystatin-7) (Cystatin-like metastasis-associated protein) (CMAP) (Leukocystatin)	CST7	Homo sapiens (Human)	145	FUNCTION: Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.		immune response [GO:0006955]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of peptidase activity [GO:0010466]; positive regulation of myelination [GO:0031643]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosome [GO:0005764]; multivesicular body [GO:0005771]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; peptidase inhibitor activity [GO:0030414]; protein homodimerization activity [GO:0042803]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; peptidase inhibitor activity [GO:0030414]; protein homodimerization activity [GO:0042803]; immune response [GO:0006955]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of peptidase activity [GO:0010466]; positive regulation of myelination [GO:0031643]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12423348}. Cytoplasm {ECO:0000269|PubMed:12423348}.
O77932	reviewed	DXO_HUMAN	Decapping and exoribonuclease protein (DXO) (EC 3.6.1.-) (5'-3' exoribonuclease DXO) (EC 3.1.13.-) (Dom-3 homolog Z) (NAD-capped RNA hydrolase DXO) (DeNADding enzyme DXO) (EC 3.6.1.-)	DXO DOM3L DOM3Z NG6	Homo sapiens (Human)	396	FUNCTION: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (PubMed:28283058). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs (PubMed:28283058). In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:28283058). Preferentially acts on NAD-capped transcripts in response to environmental stress (PubMed:31101919). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (By similarity). Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control (By similarity). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (PubMed:29601584). In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA (By similarity). Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs (PubMed:29601584). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Exhibits decapping activity towards FAD-capped RNAs (PubMed:32374864). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). {ECO:0000250|UniProtKB:O70348, ECO:0000269|PubMed:28283058, ECO:0000269|PubMed:29601584, ECO:0000269|PubMed:31101919, ECO:0000269|PubMed:32374864}.		mRNA catabolic process [GO:0006402]; NAD-cap decapping [GO:0110155]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; RNA destabilization [GO:0050779]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	5'-3' exonuclease activity [GO:0008409]; magnesium ion binding [GO:0000287]; mRNA 5'-diphosphatase activity [GO:0034353]; mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; RNA NAD-cap (NAD-forming) hydrolase activity [GO:0110152]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; 5'-3' exonuclease activity [GO:0008409]; magnesium ion binding [GO:0000287]; mRNA 5'-diphosphatase activity [GO:0034353]; mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; RNA NAD-cap (NAD-forming) hydrolase activity [GO:0110152]; mRNA catabolic process [GO:0006402]; NAD-cap decapping [GO:0110155]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; RNA destabilization [GO:0050779]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21750099, ECO:0000269|PubMed:29601584}.
O94759	reviewed	TRPM2_HUMAN	Transient receptor potential cation channel subfamily M member 2 (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) (Transient receptor potential melastatin 2)	TRPM2 EREG1 KNP3 LTRPC2 TRPC7	Homo sapiens (Human)	1503	FUNCTION: [Isoform 1]: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11960981, PubMed:12594222, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:28775320, PubMed:29745897, PubMed:30467180). Functions as ligand-gated ion channel (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:30467180). Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:29745897, PubMed:30467180). Extracellular calcium passes through the channel and increases channel activity (PubMed:19171771). Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:11960981, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:30467180). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed:20650899, PubMed:25918360). Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed:22493272). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606). {ECO:0000250|UniProtKB:Q91YD4, ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:11509734, ECO:0000269|PubMed:11804595, ECO:0000269|PubMed:11960981, ECO:0000269|PubMed:12594222, ECO:0000269|PubMed:15561722, ECO:0000269|PubMed:16601673, ECO:0000269|PubMed:19171771, ECO:0000269|PubMed:19454650, ECO:0000269|PubMed:20650899, ECO:0000269|PubMed:20660597, ECO:0000269|PubMed:22493272, ECO:0000269|PubMed:25562606, ECO:0000269|PubMed:25620041, ECO:0000269|PubMed:25918360, ECO:0000269|PubMed:27068538, ECO:0000269|PubMed:27383051, ECO:0000269|PubMed:28775320, ECO:0000269|PubMed:29745897, ECO:0000269|PubMed:30467180, ECO:0000305}.; FUNCTION: [Isoform 2]: Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP-ribose. {ECO:0000269|PubMed:11960981}.; FUNCTION: [Isoform 3]: Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress. {ECO:0000269|PubMed:12594222}.		calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to purine-containing compound [GO:0071415]; cellular response to temperature stimulus [GO:0071502]; dendritic cell chemotaxis [GO:0002407]; dendritic cell differentiation [GO:0097028]; protein homotetramerization [GO:0051289]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of filopodium assembly [GO:0051489]; release of sequestered calcium ion into cytosol [GO:0051209]; response to heat [GO:0009408]; response to hydroperoxide [GO:0033194]; response to purine-containing compound [GO:0014074]; temperature homeostasis [GO:0001659]; zinc ion transmembrane transport [GO:0071577]	cell projection [GO:0042995]; cytoplasmic vesicle membrane [GO:0030659]; ficolin-1-rich granule membrane [GO:0101003]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-release channel activity [GO:0015278]; ligand-gated calcium channel activity [GO:0099604]; manganese ion transmembrane transporter activity [GO:0005384]; mono-ADP-D-ribose binding [GO:0072571]; monoatomic cation channel activity [GO:0005261]; sodium channel activity [GO:0005272]	cell projection [GO:0042995]; cytoplasmic vesicle membrane [GO:0030659]; ficolin-1-rich granule membrane [GO:0101003]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-release channel activity [GO:0015278]; ligand-gated calcium channel activity [GO:0099604]; manganese ion transmembrane transporter activity [GO:0005384]; mono-ADP-D-ribose binding [GO:0072571]; monoatomic cation channel activity [GO:0005261]; sodium channel activity [GO:0005272]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to purine-containing compound [GO:0071415]; cellular response to temperature stimulus [GO:0071502]; dendritic cell chemotaxis [GO:0002407]; dendritic cell differentiation [GO:0097028]; protein homotetramerization [GO:0051289]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of filopodium assembly [GO:0051489]; release of sequestered calcium ion into cytosol [GO:0051209]; response to heat [GO:0009408]; response to hydroperoxide [GO:0033194]; response to purine-containing compound [GO:0014074]; temperature homeostasis [GO:0001659]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:11509734, ECO:0000269|PubMed:11804595, ECO:0000269|PubMed:12594222, ECO:0000269|PubMed:15561722, ECO:0000269|PubMed:16601673, ECO:0000269|PubMed:19171771, ECO:0000269|PubMed:20650899, ECO:0000269|PubMed:20660597, ECO:0000269|PubMed:22493272, ECO:0000269|PubMed:25918360, ECO:0000269|PubMed:27068538, ECO:0000269|PubMed:27383051, ECO:0000269|PubMed:30467180}; Multi-pass membrane protein {ECO:0000269|PubMed:30467180}. Perikaryon {ECO:0000250|UniProtKB:E9PTA2}. Cell projection {ECO:0000250|UniProtKB:E9PTA2}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:E9PTA2}. Lysosome {ECO:0000269|PubMed:27068538}. Note=Detected at the cell membrane and in intracellular vesicles in cortical neurons. Detected on neuronal cell bodies and neurites (By similarity). Detected on the cell membrane in polymorphonuclear neutrophils. Detected on cytoplasmic vesicles and lysosomes in immature bone marrow dendritic cells (By similarity). {ECO:0000250|UniProtKB:E9PTA2, ECO:0000250|UniProtKB:Q91YD4}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:11960981, ECO:0000269|PubMed:12594222}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11960981}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:12594222}; Multi-pass membrane protein {ECO:0000255}.
O94760	reviewed	DDAH1_HUMAN	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)	DDAH1 DDAH	Homo sapiens (Human)	285	FUNCTION: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.		arginine catabolic process [GO:0006527]; arginine metabolic process [GO:0006525]; citrulline metabolic process [GO:0000052]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of vascular permeability [GO:0043116]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide metabolic process [GO:0046209]; positive regulation of angiogenesis [GO:0045766]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of systemic arterial blood pressure [GO:0003073]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	amino acid binding [GO:0016597]; catalytic activity [GO:0003824]; dimethylargininase activity [GO:0016403]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; amino acid binding [GO:0016597]; catalytic activity [GO:0003824]; dimethylargininase activity [GO:0016403]; metal ion binding [GO:0046872]; arginine catabolic process [GO:0006527]; arginine metabolic process [GO:0006525]; citrulline metabolic process [GO:0000052]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of vascular permeability [GO:0043116]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide metabolic process [GO:0046209]; positive regulation of angiogenesis [GO:0045766]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of systemic arterial blood pressure [GO:0003073]	
O94761	reviewed	RECQ4_HUMAN	ATP-dependent DNA helicase Q4 (EC 3.6.4.12) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4)	RECQL4 RECQ4	Homo sapiens (Human)	1208	FUNCTION: DNA-dependent ATPase. May modulate chromosome segregation. {ECO:0000269|PubMed:15317757}.		DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]; telomeric D-loop disassembly [GO:0061820]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bubble DNA binding [GO:0000405]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]; oxidized purine DNA binding [GO:0032357]; telomeric D-loop binding [GO:0061821]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bubble DNA binding [GO:0000405]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]; oxidized purine DNA binding [GO:0032357]; telomeric D-loop binding [GO:0061821]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]; telomeric D-loop disassembly [GO:0061820]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15317757}. Nucleus {ECO:0000269|PubMed:10552928}.
O94762	reviewed	RECQ5_HUMAN	ATP-dependent DNA helicase Q5 (EC 3.6.4.12) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5)	RECQL5 RECQ5	Homo sapiens (Human)	991	FUNCTION: DNA helicase that plays an important role in DNA replication, transcription and repair (PubMed:20643585, PubMed:22973052). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability (PubMed:20231364). Associates also with POLR1A and enforces the stability of ribosomal DNA arrays (PubMed:27502483). Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress (PubMed:22013166). Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis (PubMed:28575661). Required for efficient DNA repair, including repair of inter-strand cross-links (PubMed:23715498). Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. {ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20643585, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22973052, ECO:0000269|PubMed:23715498, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:27502483, ECO:0000269|PubMed:28575661}.		cell division [GO:0051301]; cellular response to camptothecin [GO:0072757]; cellular response to ketone [GO:1901655]; cellular response to xenobiotic stimulus [GO:0071466]; chromosome separation [GO:0051304]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; mitotic cell cycle [GO:0000278]; mitotic DNA-templated DNA replication [GO:1990506]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; transcription preinitiation complex [GO:0097550]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; RNA polymerase II complex binding [GO:0000993]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; transcription preinitiation complex [GO:0097550]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; RNA polymerase II complex binding [GO:0000993]; cell division [GO:0051301]; cellular response to camptothecin [GO:0072757]; cellular response to ketone [GO:1901655]; cellular response to xenobiotic stimulus [GO:0071466]; chromosome separation [GO:0051304]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; mitotic cell cycle [GO:0000278]; mitotic DNA-templated DNA replication [GO:1990506]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]	SUBCELLULAR LOCATION: [Isoform Beta]: Nucleus, nucleoplasm {ECO:0000269|PubMed:10710432, ECO:0000269|PubMed:23180761, ECO:0000269|PubMed:23715498}. Nucleus {ECO:0000269|PubMed:23180761}. Note=Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks. Re-localizes from the nucleolus into the nucleus after replicative stress and significantly associates with WRN during S-phase (PubMed:23180761). {ECO:0000269|PubMed:20643585, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22973052, ECO:0000269|PubMed:23180761, ECO:0000269|PubMed:23715498}.; SUBCELLULAR LOCATION: [Isoform Alpha]: Cytoplasm {ECO:0000269|PubMed:10710432}.; SUBCELLULAR LOCATION: [Isoform Gamma]: Cytoplasm {ECO:0000269|PubMed:10710432}.
O94763	reviewed	RMP_HUMAN	Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein)	URI1 C19orf2 NNX3 PPP1R19 RMP URI	Homo sapiens (Human)	535	FUNCTION: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.		cellular response to growth factor stimulus [GO:0071363]; cellular response to steroid hormone stimulus [GO:0071383]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; regulation of cell growth [GO:0001558]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]	chromatin binding [GO:0003682]; phosphatase inhibitor activity [GO:0019212]; phosphoprotein binding [GO:0051219]; protein phosphatase inhibitor activity [GO:0004864]; RNA polymerase II complex binding [GO:0000993]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; chromatin binding [GO:0003682]; phosphatase inhibitor activity [GO:0019212]; phosphoprotein binding [GO:0051219]; protein phosphatase inhibitor activity [GO:0004864]; RNA polymerase II complex binding [GO:0000993]; transcription corepressor activity [GO:0003714]; cellular response to growth factor stimulus [GO:0071363]; cellular response to steroid hormone stimulus [GO:0071383]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; regulation of cell growth [GO:0001558]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite {ECO:0000250}. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.
O94766	reviewed	B3GA3_HUMAN	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 3) (Glucuronosyltransferase I) (GlcAT-I) (UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) (GlcUAT-I)	B3GAT3	Homo sapiens (Human)	335	FUNCTION: Glycosaminoglycans biosynthesis (PubMed:25893793). Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation (PubMed:24425863). {ECO:0000269|PubMed:24425863, ECO:0000269|PubMed:25893793}.		carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; positive regulation of catalytic activity [GO:0043085]; positive regulation of intracellular protein transport [GO:0090316]	cis-Golgi network [GO:0005801]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018]; glucuronosyltransferase activity [GO:0015020]; metal ion binding [GO:0046872]; protein phosphatase activator activity [GO:0072542]	cis-Golgi network [GO:0005801]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018]; glucuronosyltransferase activity [GO:0015020]; metal ion binding [GO:0046872]; protein phosphatase activator activity [GO:0072542]; carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; positive regulation of catalytic activity [GO:0043085]; positive regulation of intracellular protein transport [GO:0090316]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:21763480}; Single-pass type II membrane protein {ECO:0000269|PubMed:21763480}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:21763480, ECO:0000269|PubMed:25893793}.
O94768	reviewed	ST17B_HUMAN	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2)	STK17B DRAK2	Homo sapiens (Human)	372	FUNCTION: Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis. {ECO:0000250, ECO:0000269|PubMed:9786912}.		apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast apoptotic process [GO:2000271]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	actin cytoskeleton [GO:0015629]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Flemming body [GO:0090543]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actin cytoskeleton [GO:0015629]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Flemming body [GO:0090543]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast apoptotic process [GO:2000271]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9786912}. Cell membrane {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Note=Colocalizes with STK17B at the plasma membrane. {ECO:0000250}.
O94769	reviewed	ECM2_HUMAN	Extracellular matrix protein 2 (Matrix glycoprotein SC1/ECM2)	ECM2	Homo sapiens (Human)	699	FUNCTION: Promotes matrix assembly and cell adhesiveness. {ECO:0000250|UniProtKB:Q5FW85}.		cell-matrix adhesion [GO:0007160]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614]	collagen V binding [GO:0070052]; heparin binding [GO:0008201]; integrin binding [GO:0005178]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614]; collagen V binding [GO:0070052]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; cell-matrix adhesion [GO:0007160]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q5FW85}.
O94776	reviewed	MTA2_HUMAN	Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)	MTA2 MTA1L1 PID	Homo sapiens (Human)	668	FUNCTION: May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.		chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA methylation [GO:0006306]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell fate specification [GO:0042659]; regulation of fibroblast migration [GO:0010762]; regulation of stem cell differentiation [GO:2000736]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; histone deacetylase complex [GO:0000118]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; histone deacetylase complex [GO:0000118]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA methylation [GO:0006306]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell fate specification [GO:0042659]; regulation of fibroblast migration [GO:0010762]; regulation of stem cell differentiation [GO:2000736]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}.
O94777	reviewed	DPM2_HUMAN	Dolichol phosphate-mannose biosynthesis regulatory protein (Dolichol-phosphate mannose synthase subunit 2) (DPM synthase subunit 2)	DPM2 My026	Homo sapiens (Human)	84	FUNCTION: Regulates the biosynthesis of dolichol phosphate-mannose (PubMed:10835346). Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1 (PubMed:10835346). Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis (PubMed:16162815). May act by regulating the GPI-GNT complex (PubMed:10944123). {ECO:0000269|PubMed:10835346, ECO:0000269|PubMed:10944123, ECO:0000269|PubMed:16162815}.		dolichol metabolic process [GO:0019348]; GPI anchor biosynthetic process [GO:0006506]; protein O-linked mannosylation [GO:0035269]; regulation of protein stability [GO:0031647]	dolichol-phosphate-mannose synthase complex [GO:0033185]; endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]	enzyme activator activity [GO:0008047]; enzyme regulator activity [GO:0030234]	dolichol-phosphate-mannose synthase complex [GO:0033185]; endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; enzyme activator activity [GO:0008047]; enzyme regulator activity [GO:0030234]; dolichol metabolic process [GO:0019348]; GPI anchor biosynthetic process [GO:0006506]; protein O-linked mannosylation [GO:0035269]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
O94778	reviewed	AQP8_HUMAN	Aquaporin-8 (AQP-8)	AQP8	Homo sapiens (Human)	261	FUNCTION: Channel that allows the facilitated permeation of water and uncharged molecules, such as hydrogen peroxide and the neutral form of ammonia (NH3), through cellular membranes such as plasma membrane, inner mitochondrial membrane and endoplasmic reticulum membrane of several tissues (PubMed:26972385, PubMed:15948717, PubMed:18948439, PubMed:23541115, PubMed:29732408, PubMed:30579780). The transport of the ammonia neutral form induces a parallel transport of proton, at alkaline pH when the concentration of ammonia is high (By similarity). However, it is unclear whether the transport of proton takes place via the aquaporin or via an endogenous pathway (By similarity). Also, may transport ammonia analogs such as formamide and methylamine, a transport favourited at basic pH due to the increase of unprotonated (neutral) form, which is expected to favor diffusion (PubMed:15948717). Does not transport urea or glycerol (PubMed:15948717). The water transport mechanism is mercury- and copper-sensitive and passive in response to osmotic driving forces (PubMed:15948717). At the canicular plasma membrane, mediates the osmotic transport of water toward the bile canaliculus and facilitates the cAMP-induced bile canalicular water secretion, a process involved in bile formation (PubMed:18948439). In addition, mediates the hydrogen peroxide release from hepatocyte mitochondria that modulates the SREBF2-mediated cholesterol synthesis and facilitates the mitochondrial ammonia uptake which is metabolized into urea, mainly under glucagon stimulation (PubMed:30579780, PubMed:34292591). In B cells, transports the CYBB-generated hydrogen peroxide from the external leaflet of the plasma membrane to the cytosol to promote B cell activation and differentiation for signal amplification (By similarity). In the small intestine and colon system, mediates water transport through mitochondria and apical membrane of epithelial cells (By similarity). May play an important role in the adaptive response of proximal tubule cells to acidosis possibly by facilitating the mitochondrial ammonia transport (PubMed:22622463). {ECO:0000250|UniProtKB:P56404, ECO:0000250|UniProtKB:P56405, ECO:0000269|PubMed:15948717, ECO:0000269|PubMed:18948439, ECO:0000269|PubMed:22622463, ECO:0000269|PubMed:23541115, ECO:0000269|PubMed:26972385, ECO:0000269|PubMed:29732408, ECO:0000269|PubMed:30579780, ECO:0000269|PubMed:34292591}.		ammonium import across plasma membrane [GO:0140157]; ammonium transmembrane transport [GO:0072488]; B cell differentiation [GO:0030183]; cellular detoxification [GO:1990748]; cellular response to cAMP [GO:0071320]; hydrogen peroxide transmembrane transport [GO:0080170]; methylammonium transport [GO:0015843]; regulation of cholesterol biosynthetic process [GO:0045540]; transepithelial water transport [GO:0035377]; urea transport [GO:0015840]; water transport [GO:0006833]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; intracellular canaliculus [GO:0046691]; intracellular vesicle [GO:0097708]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; smooth endoplasmic reticulum membrane [GO:0030868]	ammonium transmembrane transporter activity [GO:0008519]; methylammonium channel activity [GO:0015264]; urea channel activity [GO:0015265]; water channel activity [GO:0015250]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; intracellular canaliculus [GO:0046691]; intracellular vesicle [GO:0097708]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; smooth endoplasmic reticulum membrane [GO:0030868]; ammonium transmembrane transporter activity [GO:0008519]; methylammonium channel activity [GO:0015264]; urea channel activity [GO:0015265]; water channel activity [GO:0015250]; ammonium import across plasma membrane [GO:0140157]; ammonium transmembrane transport [GO:0072488]; B cell differentiation [GO:0030183]; cellular detoxification [GO:1990748]; cellular response to cAMP [GO:0071320]; hydrogen peroxide transmembrane transport [GO:0080170]; methylammonium transport [GO:0015843]; regulation of cholesterol biosynthetic process [GO:0045540]; transepithelial water transport [GO:0035377]; urea transport [GO:0015840]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18948439}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:22622463, ECO:0000269|PubMed:34292591, ECO:0000305|PubMed:28042826}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P56404, ECO:0000250|UniProtKB:P56405}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P56405}; Multi-pass membrane protein {ECO:0000255}. Smooth endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P56404}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the hepatocyte canalicular plasma membrane (PubMed:18948439). Localized at the apical membrane of the gall-bladder epithelial cells lining both the neck and corpus regions, the pancreatic acinar cells and mucosal epithelium of the colon and jejunum (By similarity). Trafficking from intracellular vesicles to the hepatocyte canalicular plasma membrane is induced by glucagon or the second messenger 3',5'-cyclic AMP and the translocation is protein kinase A and microtubule-dependent. Localized at the brush border membranes of epithelial cells from jejunum (By similarity). Localized at the luminal membranes of crypts in ascending colon (By similarity). {ECO:0000250|UniProtKB:P56404, ECO:0000250|UniProtKB:P56405, ECO:0000269|PubMed:18948439}.
O94779	reviewed	CNTN5_HUMAN	Contactin-5 (Neural recognition molecule NB-2) (hNB-2)	CNTN5	Homo sapiens (Human)	1100	FUNCTION: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; presynapse assembly [GO:0099054]; sensory perception of sound [GO:0007605]	axon [GO:0030424]; extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; side of membrane [GO:0098552]	cell-cell adhesion mediator activity [GO:0098632]	axon [GO:0030424]; extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; side of membrane [GO:0098552]; cell-cell adhesion mediator activity [GO:0098632]; axon guidance [GO:0007411]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; presynapse assembly [GO:0099054]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
O94782	reviewed	UBP1_HUMAN	Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment]	USP1	Homo sapiens (Human)	785	FUNCTION: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}.	MISCELLANEOUS: HEK293T cells expressing reduced levels of USP1 show a higher level of ubiquitinated PCNA and an increase in point mutations upon UV irradiation.	DNA repair [GO:0006281]; monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of error-prone translesion synthesis [GO:1904333]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; protein deubiquitination [GO:0016579]; regulation of DNA repair [GO:0006282]; response to UV [GO:0009411]; skeletal system development [GO:0001501]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233]; DNA repair [GO:0006281]; monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of error-prone translesion synthesis [GO:1904333]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; protein deubiquitination [GO:0016579]; regulation of DNA repair [GO:0006282]; response to UV [GO:0009411]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15694335}.
O94788	reviewed	AL1A2_HUMAN	Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (ALDH1A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II))	ALDH1A2 RALDH2	Homo sapiens (Human)	518	FUNCTION: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:29240402, PubMed:33565183). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (PubMed:33565183) (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal (By similarity). Displays complete lack of activity with citral (By similarity). {ECO:0000250|UniProtKB:Q63639, ECO:0000269|PubMed:29240402, ECO:0000269|PubMed:33565183, ECO:0000305|PubMed:22075477}.		9-cis-retinoic acid biosynthetic process [GO:0042904]; blood vessel development [GO:0001568]; cardiac muscle tissue development [GO:0048738]; cell population proliferation [GO:0008283]; cellular response to retinoic acid [GO:0071300]; determination of bilateral symmetry [GO:0009855]; embryonic camera-type eye development [GO:0031076]; embryonic digestive tract development [GO:0048566]; embryonic forelimb morphogenesis [GO:0035115]; face development [GO:0060324]; heart morphogenesis [GO:0003007]; hindbrain development [GO:0030902]; kidney development [GO:0001822]; liver development [GO:0001889]; lung development [GO:0030324]; midgut development [GO:0007494]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of cell population proliferation [GO:0008285]; neural crest cell development [GO:0014032]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; pituitary gland development [GO:0021983]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; protein homotetramerization [GO:0051289]; proximal/distal pattern formation [GO:0009954]; regulation of vascular endothelial cell proliferation [GO:1905562]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoic acid metabolic process [GO:0042573]; retinoic acid receptor signaling pathway involved in somitogenesis [GO:0090242]; retinol metabolic process [GO:0042572]; ureter maturation [GO:0035799]; vitamin A metabolic process [GO:0006776]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]	3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; retinal binding [GO:0016918]; retinal dehydrogenase activity [GO:0001758]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; retinal binding [GO:0016918]; retinal dehydrogenase activity [GO:0001758]; 9-cis-retinoic acid biosynthetic process [GO:0042904]; blood vessel development [GO:0001568]; cardiac muscle tissue development [GO:0048738]; cell population proliferation [GO:0008283]; cellular response to retinoic acid [GO:0071300]; determination of bilateral symmetry [GO:0009855]; embryonic camera-type eye development [GO:0031076]; embryonic digestive tract development [GO:0048566]; embryonic forelimb morphogenesis [GO:0035115]; face development [GO:0060324]; heart morphogenesis [GO:0003007]; hindbrain development [GO:0030902]; kidney development [GO:0001822]; liver development [GO:0001889]; lung development [GO:0030324]; midgut development [GO:0007494]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of cell population proliferation [GO:0008285]; neural crest cell development [GO:0014032]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; pituitary gland development [GO:0021983]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; protein homotetramerization [GO:0051289]; proximal/distal pattern formation [GO:0009954]; regulation of vascular endothelial cell proliferation [GO:1905562]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoic acid metabolic process [GO:0042573]; retinoic acid receptor signaling pathway involved in somitogenesis [GO:0090242]; retinol metabolic process [GO:0042572]; ureter maturation [GO:0035799]; vitamin A metabolic process [GO:0006776]	SUBCELLULAR LOCATION: Cytoplasm.
O94804	reviewed	STK10_HUMAN	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase)	STK10 LOK	Homo sapiens (Human)	968	FUNCTION: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}.	MISCELLANEOUS: Inhibition by erlotinib, an orally administered EGFR tyrosine kinase inhibitor used for treatment, enhances STK10-dependent lymphocytic responses, possibly leading to the aggravation of skin inflammation observed upon treatment by erlotinib. {ECO:0000305|PubMed:21606217}.	cell cycle [GO:0007049]; lymphocyte aggregation [GO:0071593]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of lymphocyte migration [GO:2000401]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell cycle [GO:0007049]; lymphocyte aggregation [GO:0071593]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of lymphocyte migration [GO:2000401]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19255442}; Peripheral membrane protein {ECO:0000269|PubMed:19255442}.
O94805	reviewed	ACL6B_HUMAN	Actin-like protein 6B (53 kDa BRG1-associated factor B) (Actin-related protein Baf53b) (ArpNalpha) (BRG1-associated factor 53B) (BAF53B)	ACTL6B ACTL6 BAF53B	Homo sapiens (Human)	426	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity). Essential for neuronal maturation and dendrite development (PubMed:31031012). {ECO:0000250|UniProtKB:Q99MR0, ECO:0000269|PubMed:31031012, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.		chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; dendrite development [GO:0016358]; negative regulation of cell differentiation [GO:0045596]; nervous system development [GO:0007399]; neuron maturation [GO:0042551]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	chromatin binding [GO:0003682]; structural constituent of cytoskeleton [GO:0005200]; transcription coactivator activity [GO:0003713]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; chromatin binding [GO:0003682]; structural constituent of cytoskeleton [GO:0005200]; transcription coactivator activity [GO:0003713]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; dendrite development [GO:0016358]; negative regulation of cell differentiation [GO:0045596]; nervous system development [GO:0007399]; neuron maturation [GO:0042551]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000303|PubMed:26601204}.
O94806	reviewed	KPCD3_HUMAN	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu)	PRKD3 EPK2 PRKCN	Homo sapiens (Human)	890	FUNCTION: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.		protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein kinase D signaling [GO:0089700]; protein phosphorylation [GO:0006468]; sphingolipid biosynthetic process [GO:0030148]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein kinase D signaling [GO:0089700]; protein phosphorylation [GO:0006468]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18076381}. Membrane {ECO:0000269|PubMed:18076381}. Note=Translocation to the cell membrane is required for kinase activation.
O94808	reviewed	GFPT2_HUMAN	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2)	GFPT2	Homo sapiens (Human)	682	FUNCTION: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.		cellular response to leukemia inhibitory factor [GO:1990830]; energy reserve metabolic process [GO:0006112]; fructose 6-phosphate metabolic process [GO:0006002]; glutamine metabolic process [GO:0006541]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047]	cytosol [GO:0005829]	carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360]	cytosol [GO:0005829]; carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360]; cellular response to leukemia inhibitory factor [GO:1990830]; energy reserve metabolic process [GO:0006112]; fructose 6-phosphate metabolic process [GO:0006002]; glutamine metabolic process [GO:0006541]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047]	
O94810	reviewed	RGS11_HUMAN	Regulator of G-protein signaling 11 (RGS11)	RGS11	Homo sapiens (Human)	467	FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.		G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	cytoplasm [GO:0005737]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	G-protein beta-subunit binding [GO:0031681]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; G-protein beta-subunit binding [GO:0031681]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	
O94811	reviewed	TPPP_HUMAN	Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha)	TPPP TPPP1	Homo sapiens (Human)	219	FUNCTION: Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21995432, PubMed:21316364). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514). {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:21316364, ECO:0000269|PubMed:21995432, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:26289831, ECO:0000269|PubMed:31522887}.		astral microtubule organization [GO:0030953]; cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; microtubule nucleation by microtubule organizing center [GO:0051418]; microtubule polymerization [GO:0046785]; myelin assembly [GO:0032288]; negative regulation of tubulin deacetylation [GO:1904428]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; positive regulation of myelination [GO:0031643]; positive regulation of protein polymerization [GO:0032273]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of microtubule cytoskeleton organization [GO:0070507]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic Golgi apparatus [GO:0150051]	GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; microtubule nucleator activity [GO:0140490]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic Golgi apparatus [GO:0150051]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; microtubule nucleator activity [GO:0140490]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; tubulin binding [GO:0015631]; astral microtubule organization [GO:0030953]; cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; microtubule nucleation by microtubule organizing center [GO:0051418]; microtubule polymerization [GO:0046785]; myelin assembly [GO:0032288]; negative regulation of tubulin deacetylation [GO:1904428]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; positive regulation of myelination [GO:0031643]; positive regulation of protein polymerization [GO:0032273]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of microtubule cytoskeleton organization [GO:0070507]	SUBCELLULAR LOCATION: Golgi outpost {ECO:0000250|UniProtKB:D3ZQL7}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:D3ZQL7}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17105200}. Nucleus {ECO:0000269|PubMed:18028908}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:22328514}. Note=Specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity). Mainly localizes to the cytoskeleton (PubMed:18028908). Also found in the nucleus; however, nuclear localization is unclear and requires additional evidences (PubMed:18028908). Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies (PubMed:15590652, PubMed:17027006). During mitosis, colocalizes with LIMK2 at the mitotic spindle (PubMed:22328514). {ECO:0000250|UniProtKB:D3ZQL7, ECO:0000269|PubMed:15590652, ECO:0000269|PubMed:17027006, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514}.
O94812	reviewed	BAIP3_HUMAN	BAI1-associated protein 3 (BAP3) (Brain-specific angiogenesis inhibitor I-associated protein 3)	BAIAP3 KIAA0734	Homo sapiens (Human)	1187	FUNCTION: Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (PubMed:28626000). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity). {ECO:0000250|UniProtKB:Q80TT2, ECO:0000269|PubMed:28626000}.		dense core granule maturation [GO:1990502]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of neurotransmitter secretion [GO:0001956]; regulation of behavior [GO:0050795]; regulation of dense core granule exocytosis [GO:1905413]; regulation of synaptic transmission, GABAergic [GO:0032228]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; recycling endosome membrane [GO:0055038]; secretory vesicle [GO:0099503]; trans-Golgi network membrane [GO:0032588]	calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]	cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; recycling endosome membrane [GO:0055038]; secretory vesicle [GO:0099503]; trans-Golgi network membrane [GO:0032588]; calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; dense core granule maturation [GO:1990502]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of neurotransmitter secretion [GO:0001956]; regulation of behavior [GO:0050795]; regulation of dense core granule exocytosis [GO:1905413]; regulation of synaptic transmission, GABAergic [GO:0032228]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:28626000}. Recycling endosome membrane {ECO:0000269|PubMed:28626000}; Peripheral membrane protein {ECO:0000305|PubMed:28626000}. Late endosome membrane {ECO:0000269|PubMed:28626000}; Peripheral membrane protein {ECO:0000305|PubMed:28626000}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:28626000}; Peripheral membrane protein {ECO:0000305|PubMed:28626000}. Cell membrane {ECO:0000269|PubMed:28626000}; Peripheral membrane protein {ECO:0000305|PubMed:28626000}. Note=Rapidly recruited to the plasma membrane and to Golgi structures in response to increased intracellular calcium concentration. {ECO:0000269|PubMed:28626000}.
O94813	reviewed	SLIT2_HUMAN	Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product]	SLIT2 SLIL3	Homo sapiens (Human)	1529	FUNCTION: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration. {ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:10864954, ECO:0000269|PubMed:10975526, ECO:0000269|PubMed:11239147, ECO:0000269|PubMed:11309622, ECO:0000269|PubMed:11404413}.		aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to heparin [GO:0071504]; cellular response to hormone stimulus [GO:0032870]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; corticospinal neuron axon guidance through spinal cord [GO:0021972]; induction of negative chemotaxis [GO:0050929]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of vascular permeability [GO:0043116]; positive regulation of apoptotic process [GO:0043065]; positive regulation of axonogenesis [GO:0050772]; pulmonary valve morphogenesis [GO:0003184]; response to cortisol [GO:0051414]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; GTPase inhibitor activity [GO:0005095]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; laminin-1 binding [GO:0043237]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; Roundabout binding [GO:0048495]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; GTPase inhibitor activity [GO:0005095]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; laminin-1 binding [GO:0043237]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; Roundabout binding [GO:0048495]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to heparin [GO:0071504]; cellular response to hormone stimulus [GO:0032870]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; corticospinal neuron axon guidance through spinal cord [GO:0021972]; induction of negative chemotaxis [GO:0050929]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of vascular permeability [GO:0043116]; positive regulation of apoptotic process [GO:0043065]; positive regulation of axonogenesis [GO:0050772]; pulmonary valve morphogenesis [GO:0003184]; response to cortisol [GO:0051414]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10102268}. Note=The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.
O94817	reviewed	ATG12_HUMAN	Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like)	ATG12 APG12 APG12L	Homo sapiens (Human)	140	FUNCTION: Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. {ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:17999726, ECO:0000269|PubMed:19074260, ECO:0000269|PubMed:19164948, ECO:0000269|PubMed:23202584}.; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established (PubMed:19666601). {ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:19666601}.	MISCELLANEOUS: Small amount of ATG5-ATG12 conjugate is enough to perform normal autophagy.	autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; macroautophagy [GO:0016236]; negative regulation of defense response to virus [GO:0050687]; negative regulation of innate immune response [GO:0045824]; negative regulation of type I interferon production [GO:0032480]; nucleophagy [GO:0044804]; positive regulation of viral translation [GO:1904973]; regulation of autophagosome maturation [GO:1901096]	Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome [GO:0005776]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site membrane [GO:0034045]; protein-containing complex [GO:0032991]; transferase complex [GO:1990234]		Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome [GO:0005776]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site membrane [GO:0034045]; protein-containing complex [GO:0032991]; transferase complex [GO:1990234]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; macroautophagy [GO:0016236]; negative regulation of defense response to virus [GO:0050687]; negative regulation of innate immune response [GO:0045824]; negative regulation of type I interferon production [GO:0032480]; nucleophagy [GO:0044804]; positive regulation of viral translation [GO:1904973]; regulation of autophagosome maturation [GO:1901096]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000269|PubMed:22342342}; Peripheral membrane protein {ECO:0000269|PubMed:22342342}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
O94818	reviewed	NOL4_HUMAN	Nucleolar protein 4 (Nucleolar-localized protein)	NOL4 NOLP HRIHFB2255	Homo sapiens (Human)	638				nucleolus [GO:0005730]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:9813152, ECO:0000269|PubMed:9853615}.
O94822	reviewed	LTN1_HUMAN	E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294)	LTN1 C21orf10 C21orf98 KIAA0714 RNF160 ZNF294 HSPC087	Homo sapiens (Human)	1766	FUNCTION: E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875, PubMed:28757607). Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains (PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). {ECO:0000250|UniProtKB:Q04781, ECO:0000269|PubMed:23685075, ECO:0000269|PubMed:25132172, ECO:0000269|PubMed:25578875, ECO:0000269|PubMed:28757607}.		protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; RQC complex [GO:1990112]	ribosomal large subunit binding [GO:0043023]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; RQC complex [GO:1990112]; ribosomal large subunit binding [GO:0043023]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:28757607}.
O94823	reviewed	AT10B_HUMAN	Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B)	ATP10B ATPVB KIAA0715	Homo sapiens (Human)	1461	FUNCTION: Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269|PubMed:32172343}.		lysosomal membrane organization [GO:0097212]; phospholipid translocation [GO:0045332]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; lysosomal membrane organization [GO:0097212]; phospholipid translocation [GO:0045332]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:32172343}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:32172343}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25947375}; Multi-pass membrane protein {ECO:0000255}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B.
O94826	reviewed	TOM70_HUMAN	Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70)	TOMM70 KIAA0719 TOM70 TOMM70A	Homo sapiens (Human)	608	FUNCTION: Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812). {ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:32728199, ECO:0000269|PubMed:35025629}.		activation of innate immune response [GO:0002218]; cellular response to virus [GO:0098586]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial inner membrane [GO:0045039]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; regulation of apoptotic process [GO:0042981]; response to thyroxine [GO:0097068]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]	mitochondrion targeting sequence binding [GO:0030943]; molecular adaptor activity [GO:0060090]; protein transmembrane transporter activity [GO:0008320]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; mitochondrion targeting sequence binding [GO:0030943]; molecular adaptor activity [GO:0060090]; protein transmembrane transporter activity [GO:0008320]; activation of innate immune response [GO:0002218]; cellular response to virus [GO:0098586]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial inner membrane [GO:0045039]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; regulation of apoptotic process [GO:0042981]; response to thyroxine [GO:0097068]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:33723040}; Single-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: Note=(Microbial infection) During parasite T.gondii-mediated infection, enriched at the interface between the host mitochondria and the parasitopharous vacuole. {ECO:0000269|PubMed:33723040}.
O94827	reviewed	PKHG5_HUMAN	Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)	PLEKHG5 KIAA0720	Homo sapiens (Human)	1006	FUNCTION: Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation (PubMed:11704860). Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (PubMed:23777631). {ECO:0000250|UniProtKB:Q66T02, ECO:0000269|PubMed:11704860, ECO:0000269|PubMed:23777631}.		endothelial cell chemotaxis [GO:0035767]; endothelial cell migration [GO:0043542]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	axon [GO:0030424]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	axon [GO:0030424]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; endothelial cell chemotaxis [GO:0035767]; endothelial cell migration [GO:0043542]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q66T02}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q66T02}. Cell membrane {ECO:0000250|UniProtKB:Q66T02}. Cell junction {ECO:0000250|UniProtKB:Q66T02}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q66T02}. Note=Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane. Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells. {ECO:0000250|UniProtKB:Q66T02}.
O94829	reviewed	IPO13_HUMAN	Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13)	IPO13 KIAA0724 RANBP13	Homo sapiens (Human)	963	FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. {ECO:0000250, ECO:0000269|PubMed:11447110, ECO:0000269|PubMed:15143176}.		protein import into nucleus [GO:0006606]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; small GTPase binding [GO:0031267]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
O94830	reviewed	DDHD2_HUMAN	Phospholipase DDHD2 (EC 3.1.1.-) (DDHD domain-containing protein 2) (KIAA0725p) (SAM, WWE and DDHD domain-containing protein 1)	DDHD2 KIAA0725 SAMWD1	Homo sapiens (Human)	711	FUNCTION: Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. {ECO:0000269|PubMed:11788596, ECO:0000269|PubMed:20932832, ECO:0000269|PubMed:22922100}.		lipid droplet organization [GO:0034389]; locomotory behavior [GO:0007626]; mitochondrial fission [GO:0000266]; positive regulation of mitochondrial fission [GO:0090141]; triglyceride catabolic process [GO:0019433]; visual learning [GO:0008542]	centriolar satellite [GO:0034451]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	metal ion binding [GO:0046872]; triglyceride lipase activity [GO:0004806]	centriolar satellite [GO:0034451]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; metal ion binding [GO:0046872]; triglyceride lipase activity [GO:0004806]; lipid droplet organization [GO:0034389]; locomotory behavior [GO:0007626]; mitochondrial fission [GO:0000266]; positive regulation of mitochondrial fission [GO:0090141]; triglyceride catabolic process [GO:0019433]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P.
O94832	reviewed	MYO1D_HUMAN	Unconventional myosin-Id	MYO1D KIAA0727	Homo sapiens (Human)	1006	FUNCTION: Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). {ECO:0000250|UniProtKB:F1PRN2, ECO:0000250|UniProtKB:Q63357}.		actin filament organization [GO:0007015]; cellular localization [GO:0051641]; early endosome to recycling endosome transport [GO:0061502]; protein transport [GO:0015031]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; apical dendrite [GO:0097440]; axolemma [GO:0030673]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; myelin sheath [GO:0043209]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904]	actin cytoskeleton [GO:0015629]; apical dendrite [GO:0097440]; axolemma [GO:0030673]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; myelin sheath [GO:0043209]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904]; actin filament organization [GO:0007015]; cellular localization [GO:0051641]; early endosome to recycling endosome transport [GO:0061502]; protein transport [GO:0015031]; vesicle transport along actin filament [GO:0030050]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q63357}. Perikaryon {ECO:0000250|UniProtKB:Q63357}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63357}. Early endosome {ECO:0000250|UniProtKB:F1PRN2}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q63357}. Note=Colocalizes with the actin cytoskeleton in the cell cortex close to the apical cell membrane. Colocalizes with cytoplasmic puncta that are reminiscent of transport vesicles. {ECO:0000250|UniProtKB:Q63357}.
O94842	reviewed	TOX4_HUMAN	TOX high mobility group box family member 4 (Epidermal Langerhans cell protein LCP1)	TOX4 C14orf92 KIAA0737	Homo sapiens (Human)	621	FUNCTION: Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation (By similarity). {ECO:0000250|UniProtKB:Q8BU11, ECO:0000269|PubMed:20516061}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357]	chromatin DNA binding [GO:0031490]	chromatin [GO:0000785]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357]; chromatin DNA binding [GO:0031490]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:20516061}. Note=Associated with chromatin.
O94850	reviewed	DEND_HUMAN	Dendrin	DDN KIAA0749	Homo sapiens (Human)	711	FUNCTION: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity). {ECO:0000250}.		positive regulation of transcription by RNA polymerase II [GO:0045944]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynaptic membrane [GO:0045211]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynaptic membrane [GO:0045211]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Perikaryon {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites. {ECO:0000250}.
O94851	reviewed	MICA2_HUMAN	[F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (MICAL C-terminal-like protein) (Mical-cL) (Molecule interacting with CasL protein 2) (MICAL-2)	MICAL2 KIAA0750 MICAL2PV1 MICAL2PV2 MICALCL	Homo sapiens (Human)	1957	FUNCTION: Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334, PubMed:29343822). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network (PubMed:34106209). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334). {ECO:0000269|PubMed:24440334, ECO:0000269|PubMed:29343822, ECO:0000269|PubMed:34106209}.		actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; heart development [GO:0007507]; heart looping [GO:0001947]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sulfur oxidation [GO:0019417]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; monooxygenase activity [GO:0004497]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; monooxygenase activity [GO:0004497]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; heart development [GO:0007507]; heart looping [GO:0001947]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sulfur oxidation [GO:0019417]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24440334}. Cytoplasm {ECO:0000250|UniProtKB:Q8BML1}.
O94855	reviewed	SC24D_HUMAN	Protein transport protein Sec24D (SEC24-related protein D)	SEC24D KIAA0755	Homo sapiens (Human)	1032	FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}.		COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; in utero embryonic development [GO:0001701]; intracellular protein transport [GO:0006886]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; intracellular membrane-bounded organelle [GO:0043231]	SNARE binding [GO:0000149]; zinc ion binding [GO:0008270]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; intracellular membrane-bounded organelle [GO:0043231]; SNARE binding [GO:0000149]; zinc ion binding [GO:0008270]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; in utero embryonic development [GO:0001701]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:10329445}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53992}; Cytoplasmic side {ECO:0000250|UniProtKB:P53992}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:10329445}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53992}; Cytoplasmic side {ECO:0000250|UniProtKB:P53992}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P53992}.
O94856	reviewed	NFASC_HUMAN	Neurofascin	NFASC KIAA0756	Homo sapiens (Human)	1347	FUNCTION: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be due to intron retention. {ECO:0000305}.	axon guidance [GO:0007411]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; myelination [GO:0042552]; peripheral nervous system development [GO:0007422]	axon [GO:0030424]; axon initial segment [GO:0043194]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; node of Ranvier [GO:0033268]; paranodal junction [GO:0033010]; plasma membrane [GO:0005886]	cell-cell adhesion mediator activity [GO:0098632]	axon [GO:0030424]; axon initial segment [GO:0043194]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; node of Ranvier [GO:0033268]; paranodal junction [GO:0033010]; plasma membrane [GO:0005886]; cell-cell adhesion mediator activity [GO:0098632]; axon guidance [GO:0007411]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; myelination [GO:0042552]; peripheral nervous system development [GO:0007422]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30850329}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 8]: Cell junction, paranodal septate junction {ECO:0000269|PubMed:30124836}.
O94864	reviewed	ST65G_HUMAN	STAGA complex 65 subunit gamma (Adenocarcinoma antigen ART1) (SPTF-associated factor 65 gamma) (STAF65gamma) (Suppressor of Ty 7-like)	SUPT7L KIAA0764	Homo sapiens (Human)	414			maintenance of protein location in nucleus [GO:0051457]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]	protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; maintenance of protein location in nucleus [GO:0051457]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863}.
O94868	reviewed	FCSD2_HUMAN	F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3)	FCHSD2 KIAA0769 SH3MD3	Homo sapiens (Human)	740	FUNCTION: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.		clathrin-dependent endocytosis [GO:0072583]; membrane organization [GO:0061024]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; protein transport [GO:0015031]; regulation of actin filament polymerization [GO:0030833]	anchoring junction [GO:0070161]; clathrin-coated pit [GO:0005905]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; stereocilium shaft [GO:0120043]	phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]	anchoring junction [GO:0070161]; clathrin-coated pit [GO:0005905]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; stereocilium shaft [GO:0120043]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; clathrin-dependent endocytosis [GO:0072583]; membrane organization [GO:0061024]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; protein transport [GO:0015031]; regulation of actin filament polymerization [GO:0030833]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3USJ8}. Cell junction {ECO:0000269|PubMed:14627983}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. Cell membrane {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}; Peripheral membrane protein {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:30249660}; Cytoplasmic side {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:30249660}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q3USJ8}. Note=Partially localized at clathrin-coated pits at the cell membrane (PubMed:30249660). Detected at the cell membrane at sites around clathrin-coated pits, very close to the clathrin-coated pits but not an intrinsic part of the clathrin-coated pits (PubMed:29887380). Colocalizes at cell-cell contacts with CDH1, but is not detected at tight junctions (PubMed:14627983). {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.
O94874	reviewed	UFL1_HUMAN	E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1)	UFL1 KIAA0776 MAXER NLBP RCAD	Homo sapiens (Human)	794	FUNCTION: E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498, PubMed:32160526, PubMed:37311461). In response to endoplasmic reticulum stress, recruited to the endoplasmic reticulum membrane by DDRGK1, and mediates ufmylation of proteins such as RPN1 and RPL26/uL24, thereby promoting reticulophagy of endoplasmic reticulum sheets (PubMed:32160526). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) via ERN1/IRE1-alpha (PubMed:23152784, PubMed:32160526). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (PubMed:32050156). Regulates inflammation in response to endoplasmic reticulum stress by promoting reticulophagy, leading to inhibit the activity of the NF-kappa-B transcription factor (By similarity). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is a collateral effect or is required for ufmylation (PubMed:20531390, PubMed:20018847). Catalyzes ufmylation of various subunits of the ribosomal complex or associated components, such as RPS3/uS3, RPS20/uS10, RPL10/uL16, RPL26/uL24 and EIF6 (By similarity). Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (PubMed:20531390). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 (PubMed:30886146). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (PubMed:25219498). Required for hematopoietic stem cell function and hematopoiesis (By similarity). Required for cardiac homeostasis (By similarity). {ECO:0000250|UniProtKB:A1A4I9, ECO:0000250|UniProtKB:Q8CCJ3, ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:20531390, ECO:0000269|PubMed:23152784, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:32050156, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:37311461}.		DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; erythrocyte differentiation [GO:0030218]; hematopoietic stem cell differentiation [GO:0060218]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein ubiquitination [GO:0031397]; osteoblast differentiation [GO:0001649]; positive regulation of autophagy [GO:0010508]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of glial cell proliferation [GO:0060252]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of inflammatory response [GO:0050727]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein localization [GO:0032880]; response to endoplasmic reticulum stress [GO:0034976]; response to L-glutamate [GO:1902065]; reticulophagy [GO:0061709]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; neuron projection [GO:0043005]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]	protein kinase binding [GO:0019901]; UFM1 ligase activity [GO:0061666]; UFM1 transferase activity [GO:0071568]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; neuron projection [GO:0043005]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]; protein kinase binding [GO:0019901]; UFM1 ligase activity [GO:0061666]; UFM1 transferase activity [GO:0071568]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; erythrocyte differentiation [GO:0030218]; hematopoietic stem cell differentiation [GO:0060218]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein ubiquitination [GO:0031397]; osteoblast differentiation [GO:0001649]; positive regulation of autophagy [GO:0010508]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of glial cell proliferation [GO:0060252]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of inflammatory response [GO:0050727]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein localization [GO:0032880]; response to endoplasmic reticulum stress [GO:0034976]; response to L-glutamate [GO:1902065]; reticulophagy [GO:0061709]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:32160526}. Cytoplasm, cytosol {ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:30886146}. Nucleus {ECO:0000269|PubMed:30886146}. Chromosome {ECO:0000269|PubMed:30886146}. Note=Recruited to double-strand breaks by the MRE11-RAD50-NBN (MRN) complex following DNA damage. {ECO:0000269|PubMed:30886146}.
O94875	reviewed	SRBS2_HUMAN	Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin)	SORBS2 ARGBP2 KIAA0777	Homo sapiens (Human)	1100	FUNCTION: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}.		cell growth involved in cardiac muscle cell development [GO:0061049]; Notch signaling pathway [GO:0007219]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Z disc [GO:0030018]	cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Z disc [GO:0030018]; cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; cell growth involved in cardiac muscle cell development [GO:0061049]; Notch signaling pathway [GO:0007219]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:9211900}. Apical cell membrane {ECO:0000269|PubMed:18559503}. Cell junction, focal adhesion {ECO:0000269|PubMed:18559503}. Cell projection, lamellipodium {ECO:0000269|PubMed:18559503}. Note=Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells. {ECO:0000269|PubMed:18559503}.
O94876	reviewed	TMCC1_HUMAN	Transmembrane and coiled-coil domains protein 1	TMCC1 KIAA0779	Homo sapiens (Human)	653	FUNCTION: Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). {ECO:0000269|PubMed:30220460}.		endoplasmic reticulum organization [GO:0007029]; endosomal transport [GO:0016197]; endosome fission [GO:0140285]; endosome membrane tubulation [GO:0097750]; membrane fission [GO:0090148]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; rough endoplasmic reticulum [GO:0005791]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; rough endoplasmic reticulum [GO:0005791]; identical protein binding [GO:0042802]; endoplasmic reticulum organization [GO:0007029]; endosomal transport [GO:0016197]; endosome fission [GO:0140285]; endosome membrane tubulation [GO:0097750]; membrane fission [GO:0090148]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24454821, ECO:0000269|PubMed:30220460}; Multi-pass membrane protein {ECO:0000255}. Note=Specifically localizes to contact sites between the endoplasmic reticulum and endosomes that are spatially and temporally linked to endosome fission. {ECO:0000269|PubMed:30220460}.
O94880	reviewed	PHF14_HUMAN	PHD finger protein 14	PHF14 KIAA0783	Homo sapiens (Human)	948	FUNCTION: Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}.	MISCELLANEOUS: [Isoform 3]: Dubious isoform. Alternative initiation from a downstream AUG is supported by ribosome profiling data. {ECO:0000305}.	germinal center B cell differentiation [GO:0002314]; lung alveolus development [GO:0048286]; mesenchymal cell proliferation [GO:0010463]; mesenchymal cell proliferation involved in lung development [GO:0060916]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of mesenchymal cell proliferation involved in lung development [GO:2000791]; negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000584]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	histone binding [GO:0042393]; histone reader activity [GO:0140566]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; zinc ion binding [GO:0008270]; germinal center B cell differentiation [GO:0002314]; lung alveolus development [GO:0048286]; mesenchymal cell proliferation [GO:0010463]; mesenchymal cell proliferation involved in lung development [GO:0060916]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of mesenchymal cell proliferation involved in lung development [GO:2000791]; negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000584]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:23688586}. Chromosome {ECO:0000269|PubMed:23688586}. Note=Mainly localized in the nucleus of interphase cells. In mitotic cells, colocalizes with condensed chromatin during metaphase and anaphase. {ECO:0000269|PubMed:23688586}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:23688586}.
O94885	reviewed	SASH1_HUMAN	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein)	SASH1 KIAA0790 PEPE1	Homo sapiens (Human)	1247	FUNCTION: Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}.		positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; protein polyubiquitination [GO:0000209]; regulation of epithelial cell migration [GO:0010632]; regulation of protein autoubiquitination [GO:1902498]; regulation of protein K63-linked ubiquitination [GO:1900044]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	G-protein alpha-subunit binding [GO:0001965]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; G-protein alpha-subunit binding [GO:0001965]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; protein polyubiquitination [GO:0000209]; regulation of epithelial cell migration [GO:0010632]; regulation of protein autoubiquitination [GO:1902498]; regulation of protein K63-linked ubiquitination [GO:1900044]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23333244}.
O94886	reviewed	CSCL1_HUMAN	CSC1-like protein 1 (Transmembrane protein 63A)	TMEM63A KIAA0489 KIAA0792	Homo sapiens (Human)	807	FUNCTION: Acts as an osmosensitive calcium-permeable cation channel (PubMed:30382938, PubMed:31587869). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (PubMed:30382938, PubMed:31587869). {ECO:0000250|UniProtKB:Q91YT8, ECO:0000269|PubMed:30382938, ECO:0000269|PubMed:31587869}.			centriolar satellite [GO:0034451]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	calcium activated cation channel activity [GO:0005227]; mechanosensitive monoatomic ion channel activity [GO:0008381]; nucleic acid binding [GO:0003676]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]	centriolar satellite [GO:0034451]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; calcium activated cation channel activity [GO:0005227]; mechanosensitive monoatomic ion channel activity [GO:0008381]; nucleic acid binding [GO:0003676]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:20957757}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q91YT8}; Multi-pass membrane protein {ECO:0000255}.
O94887	reviewed	FARP2_HUMAN	FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)	FARP2 KIAA0793 PLEKHC3	Homo sapiens (Human)	1054	FUNCTION: Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.		actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; hair cycle process [GO:0022405]; neuron remodeling [GO:0016322]; osteoclast differentiation [GO:0030316]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; regulation of integrin activation [GO:0033623]; semaphorin-plexin signaling pathway [GO:0071526]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]	cytoskeletal protein binding [GO:0008092]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; cytoskeletal protein binding [GO:0008092]; guanyl-nucleotide exchange factor activity [GO:0005085]; actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; hair cycle process [GO:0022405]; neuron remodeling [GO:0016322]; osteoclast differentiation [GO:0030316]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; regulation of integrin activation [GO:0033623]; semaphorin-plexin signaling pathway [GO:0071526]	
O94888	reviewed	UBXN7_HUMAN	UBX domain-containing protein 7	UBXN7 KIAA0794 UBXD7	Homo sapiens (Human)	489	FUNCTION: Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. {ECO:0000269|PubMed:22537386}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22537386}.
O94898	reviewed	LRIG2_HUMAN	Leucine-rich repeats and immunoglobulin-like domains protein 2 (LIG-2)	LRIG2 KIAA0806 LIG2	Homo sapiens (Human)	1065			innervation [GO:0060384]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of axon regeneration [GO:0048681]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to cell surface [GO:0034394]; regulation of neuron migration [GO:2001222]; regulation of platelet-derived growth factor receptor signaling pathway [GO:0010640]; sensory perception of sound [GO:0007605]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; growth cone [GO:0030426]; intracellular vesicle [GO:0097708]; plasma membrane [GO:0005886]	signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; growth cone [GO:0030426]; intracellular vesicle [GO:0097708]; plasma membrane [GO:0005886]; signaling receptor binding [GO:0005102]; innervation [GO:0060384]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of axon regeneration [GO:0048681]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to cell surface [GO:0034394]; regulation of neuron migration [GO:2001222]; regulation of platelet-derived growth factor receptor signaling pathway [GO:0010640]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15145052}; Single-pass type I membrane protein {ECO:0000269|PubMed:15145052}. Cytoplasm {ECO:0000269|PubMed:15145052}.
O94900	reviewed	TOX_HUMAN	Thymocyte selection-associated high mobility group box protein TOX (Thymus high mobility group box protein TOX)	TOX KIAA0808	Homo sapiens (Human)	526	FUNCTION: Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (By similarity). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (By similarity). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC) (By similarity). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (PubMed:21126536) (By similarity). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (By similarity). {ECO:0000250|UniProtKB:Q66JW3, ECO:0000269|PubMed:21126536}.		CD4-positive, alpha-beta T cell lineage commitment [GO:0043373]; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment [GO:0002362]; CD8-positive, alpha-beta T cell lineage commitment [GO:0043375]; cerebral cortex neuron differentiation [GO:0021895]; chromatin organization [GO:0006325]; leukocyte differentiation [GO:0002521]; lymph node development [GO:0048535]; natural killer cell differentiation [GO:0001779]; NK T cell lineage commitment [GO:0002364]; Peyer's patch development [GO:0048541]; positive regulation of DNA demethylation [GO:1901537]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuron projection development [GO:0010976]; regulation of positive thymic T cell selection [GO:1902232]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]	nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; CD4-positive, alpha-beta T cell lineage commitment [GO:0043373]; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment [GO:0002362]; CD8-positive, alpha-beta T cell lineage commitment [GO:0043375]; cerebral cortex neuron differentiation [GO:0021895]; chromatin organization [GO:0006325]; leukocyte differentiation [GO:0002521]; lymph node development [GO:0048535]; natural killer cell differentiation [GO:0001779]; NK T cell lineage commitment [GO:0002364]; Peyer's patch development [GO:0048541]; positive regulation of DNA demethylation [GO:1901537]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuron projection development [GO:0010976]; regulation of positive thymic T cell selection [GO:1902232]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
O94901	reviewed	SUN1_HUMAN	SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1)	SUN1 KIAA0810 UNC84A	Homo sapiens (Human)	785	FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709). {ECO:0000250|UniProtKB:Q9D666, ECO:0000269|PubMed:18039933, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:24375709}.		centrosome localization [GO:0051642]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; ossification [GO:0001503]; response to mechanical stimulus [GO:0009612]; spermatogenesis [GO:0007283]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]	cytoskeleton-nuclear membrane anchor activity [GO:0140444]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein-membrane adaptor activity [GO:0043495]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; cytoskeleton-nuclear membrane anchor activity [GO:0140444]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein-membrane adaptor activity [GO:0043495]; centrosome localization [GO:0051642]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; ossification [GO:0001503]; response to mechanical stimulus [GO:0009612]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:12958361, ECO:0000269|PubMed:16445915, ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:18845190, ECO:0000269|PubMed:19933576}; Single-pass type II membrane protein {ECO:0000269|PubMed:12958361, ECO:0000269|PubMed:16445915, ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:18845190, ECO:0000269|PubMed:19933576}. Note=At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles. {ECO:0000250|UniProtKB:Q9D666}.
O94905	reviewed	ERLN2_HUMAN	Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2)	ERLIN2 C8orf2 SPFH2 UNQ2441/PRO5003/PRO9924	Homo sapiens (Human)	339	FUNCTION: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618). {ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031, ECO:0000269|PubMed:21343306, ECO:0000269|PubMed:24217618}.		cholesterol metabolic process [GO:0008203]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of fatty acid biosynthetic process [GO:0045717]; regulation of cholesterol biosynthetic process [GO:0045540]; SREBP signaling pathway [GO:0032933]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	cholesterol binding [GO:0015485]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; cholesterol binding [GO:0015485]; ubiquitin protein ligase binding [GO:0031625]; cholesterol metabolic process [GO:0008203]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of fatty acid biosynthetic process [GO:0045717]; regulation of cholesterol biosynthetic process [GO:0045540]; SREBP signaling pathway [GO:0032933]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16835267, ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031}; Single-pass type II membrane protein {ECO:0000269|PubMed:16835267, ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
O94906	reviewed	PRP6_HUMAN	Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)	PRPF6 C20orf14	Homo sapiens (Human)	941	FUNCTION: Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:28781166, PubMed:21549338). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962, ECO:0000269|PubMed:21549338, ECO:0000269|PubMed:28781166}.		mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA localization [GO:0006403]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]	identical protein binding [GO:0042802]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; identical protein binding [GO:0042802]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA localization [GO:0006403]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:10561546, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:34023904}. Nucleus speckle {ECO:0000269|PubMed:21549338}. Note=Localized in splicing speckles. {ECO:0000269|PubMed:21549338}.
O94907	reviewed	DKK1_HUMAN	Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK)	DKK1 UNQ492/PRO1008	Homo sapiens (Human)	266	FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity). {ECO:0000250|UniProtKB:O54908, ECO:0000269|PubMed:22000856, ECO:0000303|PubMed:17143291}.		canonical Wnt signaling pathway [GO:0060070]; cell morphogenesis involved in differentiation [GO:0000904]; embryonic limb morphogenesis [GO:0030326]; endocardial cushion development [GO:0003197]; endoderm formation [GO:0001706]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; hair follicle development [GO:0001942]; heart valve development [GO:0003170]; learning or memory [GO:0007611]; limb development [GO:0060173]; mesoderm formation [GO:0001707]; motor learning [GO:0061743]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [GO:1901296]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of mesodermal cell fate specification [GO:0042662]; negative regulation of neuron projection development [GO:0010977]; negative regulation of ossification [GO:0030279]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of presynapse assembly [GO:1905607]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; negative regulation of Wnt-Frizzled-LRP5/6 complex assembly [GO:1904723]; positive regulation of gene expression [GO:0010628]; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [GO:0090082]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of midbrain dopaminergic neuron differentiation [GO:1904958]; positive regulation of tau-protein kinase activity [GO:1902949]; positive regulation of Wnt signaling pathway, calcium modulating pathway [GO:0045813]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of endodermal cell fate specification [GO:0042663]; regulation of neuron apoptotic process [GO:0043523]; regulation of receptor internalization [GO:0002090]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to retinoic acid [GO:0032526]; synapse pruning [GO:0098883]; Wnt signaling pathway involved in somitogenesis [GO:0090244]	early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	co-receptor binding [GO:0039706]; growth factor activity [GO:0008083]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019]	early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; co-receptor binding [GO:0039706]; growth factor activity [GO:0008083]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019]; canonical Wnt signaling pathway [GO:0060070]; cell morphogenesis involved in differentiation [GO:0000904]; embryonic limb morphogenesis [GO:0030326]; endocardial cushion development [GO:0003197]; endoderm formation [GO:0001706]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; hair follicle development [GO:0001942]; heart valve development [GO:0003170]; learning or memory [GO:0007611]; limb development [GO:0060173]; mesoderm formation [GO:0001707]; motor learning [GO:0061743]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [GO:1901296]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of mesodermal cell fate specification [GO:0042662]; negative regulation of neuron projection development [GO:0010977]; negative regulation of ossification [GO:0030279]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of presynapse assembly [GO:1905607]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; negative regulation of Wnt-Frizzled-LRP5/6 complex assembly [GO:1904723]; positive regulation of gene expression [GO:0010628]; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [GO:0090082]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of midbrain dopaminergic neuron differentiation [GO:1904958]; positive regulation of tau-protein kinase activity [GO:1902949]; positive regulation of Wnt signaling pathway, calcium modulating pathway [GO:0045813]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of endodermal cell fate specification [GO:0042663]; regulation of neuron apoptotic process [GO:0043523]; regulation of receptor internalization [GO:0002090]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to retinoic acid [GO:0032526]; synapse pruning [GO:0098883]; Wnt signaling pathway involved in somitogenesis [GO:0090244]	SUBCELLULAR LOCATION: Secreted.
O94910	reviewed	AGRL1_HUMAN	Adhesion G protein-coupled receptor L1 (Calcium-independent alpha-latrotoxin receptor 1) (CIRL-1) (Latrophilin-1) (Lectomedin-2)	ADGRL1 KIAA0821 LEC2 LPHN1	Homo sapiens (Human)	1474	FUNCTION: Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells (PubMed:35907405). Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). {ECO:0000250|UniProtKB:O88917, ECO:0000269|PubMed:35907405}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; positive regulation of synapse maturation [GO:0090129]	axon [GO:0030424]; growth cone [GO:0030426]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]	carbohydrate binding [GO:0030246]; cell adhesion molecule binding [GO:0050839]; G protein-coupled receptor activity [GO:0004930]; latrotoxin receptor activity [GO:0016524]	axon [GO:0030424]; growth cone [GO:0030426]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; carbohydrate binding [GO:0030246]; cell adhesion molecule binding [GO:0050839]; G protein-coupled receptor activity [GO:0004930]; latrotoxin receptor activity [GO:0016524]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; positive regulation of synapse maturation [GO:0090129]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:35907405}; Multi-pass membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:O88917}. Cell projection, growth cone {ECO:0000250|UniProtKB:O88917}. Synapse {ECO:0000250|UniProtKB:O88917}. Presynaptic cell membrane {ECO:0000250|UniProtKB:O88917}. Synapse, synaptosome {ECO:0000250|UniProtKB:O88917}. Note=Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts. {ECO:0000250|UniProtKB:O88917}.
O94911	reviewed	ABCA8_HUMAN	ABC-type organic anion transporter ABCA8 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 8)	ABCA8 KIAA0822	Homo sapiens (Human)	1621	FUNCTION: [Isoform 1]: Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate (PubMed:12379217). In vitro, also imports ochratoxin A (PubMed:12379217). Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes (PubMed:23560799). {ECO:0000269|PubMed:12379217, ECO:0000269|PubMed:23560799}.; FUNCTION: [Isoform 3]: Catalyzes ATP-dependent efflux of cholesterol and taurocholate (PubMed:29300488). Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels (PubMed:28882873). {ECO:0000269|PubMed:28882873, ECO:0000269|PubMed:29300488}.		cholesterol efflux [GO:0033344]; cholesterol transport [GO:0030301]; lipid transport [GO:0006869]; positive regulation of cholesterol efflux [GO:0010875]; regulation of cholesterol efflux [GO:0010874]; sphingomyelin biosynthetic process [GO:0006686]; transmembrane transport [GO:0055085]; xenobiotic transport [GO:0042908]	basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]	basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; cholesterol efflux [GO:0033344]; cholesterol transport [GO:0030301]; lipid transport [GO:0006869]; positive regulation of cholesterol efflux [GO:0010875]; regulation of cholesterol efflux [GO:0010874]; sphingomyelin biosynthetic process [GO:0006686]; transmembrane transport [GO:0055085]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28882873, ECO:0000269|PubMed:29300488}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8K440}. Note=Predominantly expressed on the sinusoidal plasma membrane. {ECO:0000250|UniProtKB:Q8K440}.
O94913	reviewed	PCF11_HUMAN	Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11)	PCF11 KIAA0824	Homo sapiens (Human)	1555	FUNCTION: Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}.		co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; RNA polymerase II complex binding [GO:0000993]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA polymerase II complex binding [GO:0000993]; co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29196535}.
O94915	reviewed	FRYL_HUMAN	Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein)	FRYL AF4P12 KIAA0826	Homo sapiens (Human)	3013	FUNCTION: Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}.		cell morphogenesis [GO:0000902]; neuron projection development [GO:0031175]	cell cortex [GO:0005938]; site of polarized growth [GO:0030427]		cell cortex [GO:0005938]; site of polarized growth [GO:0030427]; cell morphogenesis [GO:0000902]; neuron projection development [GO:0031175]	
O94916	reviewed	NFAT5_HUMAN	Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP)	NFAT5 KIAA0827 TONEBP	Homo sapiens (Human)	1531	FUNCTION: Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}.	MISCELLANEOUS: [Isoform A]: The transcript encoding this isoform contains an alternative coding exon 4 which contains 2 stop codons and could target the transcript to nonsense-mediated mRNA decay after the pioneer round of translation, as suggested by the decreased NFAT5 protein levels when the number of exon 4-containing transcripts increases. The insertion of exon 4 is stimulated in the presence of DDX5 and DDX17. Isoform A sequence described in this entry starts at the first methionine downstream of exon 4 last stop codon. An alternative protein sequence can be predicted from this transcript starting at Met-1. This isoform encodes an 81 amino acid-long protein. {ECO:0000269|PubMed:22266867, ECO:0000305}.; MISCELLANEOUS: [Isoform B]: The transcript encoding this isoform contains an alternative coding exon 4 which contains 2 stop codons and could target the transcript to nonsense-mediated mRNA decay after the pioneer round of translation, as suggested by the decreased NFAT5 protein levels when the number of exon 4-containing transcripts increases. The insertion of exon 4 is stimulated in the presence of DDX5 and DDX17. {ECO:0000269|PubMed:22266867, ECO:0000305}.	calcineurin-NFAT signaling cascade [GO:0033173]; cellular hyperosmotic response [GO:0071474]; cellular response to cytokine stimulus [GO:0071345]; DNA damage response [GO:0006974]; positive regulation of gene expression [GO:0010628]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; R-loop processing [GO:0062176]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; calcineurin-NFAT signaling cascade [GO:0033173]; cellular hyperosmotic response [GO:0071474]; cellular response to cytokine stimulus [GO:0071345]; DNA damage response [GO:0006974]; positive regulation of gene expression [GO:0010628]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; R-loop processing [GO:0062176]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10377394}. Cytoplasm {ECO:0000250|UniProtKB:Q9WV30}. Chromosome {ECO:0000269|PubMed:34049076}. Note=Nuclear distribution increases under hypertonic conditions (By similarity). Recruited to sites of R-loop-associated DNA damage following poly-ADP-ribosylation by PARP1 (PubMed:34049076). {ECO:0000250|UniProtKB:Q9WV30, ECO:0000269|PubMed:34049076}.
O94919	reviewed	ENDD1_HUMAN	Endonuclease domain-containing 1 protein (EC 3.1.30.-)	ENDOD1 KIAA0830	Homo sapiens (Human)	500	FUNCTION: May act as a DNase and a RNase. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. {ECO:0000269|PubMed:32614325}.		innate immune response [GO:0045087]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]	endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O94921	reviewed	CDK14_HUMAN	Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1)	CDK14 KIAA0834 PFTK1	Homo sapiens (Human)	469	FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}.		cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; phosphorylation [GO:0016310]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; Wnt signaling pathway [GO:0016055]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytoplasmic cyclin-dependent protein kinase holoenzyme complex [GO:0000308]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytoplasmic cyclin-dependent protein kinase holoenzyme complex [GO:0000308]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; phosphorylation [GO:0016310]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY.
O94923	reviewed	GLCE_HUMAN	D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase)	GLCE KIAA0836	Homo sapiens (Human)	617	FUNCTION: Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. {ECO:0000269|PubMed:20118238, ECO:0000269|PubMed:22528493, ECO:0000269|PubMed:30872481}.		heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	calcium ion binding [GO:0005509]; heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464]; protein homodimerization activity [GO:0042803]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; calcium ion binding [GO:0005509]; heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464]; protein homodimerization activity [GO:0042803]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EPS3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9EPS3}.
O94925	reviewed	GLSK_HUMAN	Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain]	GLS GLS1 KIAA0838	Homo sapiens (Human)	669	FUNCTION: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30575854, PubMed:30239721, PubMed:30970188). {ECO:0000269|PubMed:30239721, ECO:0000269|PubMed:30575854, ECO:0000269|PubMed:30970188}.; FUNCTION: [Isoform 2]: Lacks catalytic activity. {ECO:0000269|PubMed:11015561}.		chemical synaptic transmission [GO:0007268]; glutamate biosynthetic process [GO:0006537]; glutamine catabolic process [GO:0006543]; intracellular glutamate homeostasis [GO:0090461]; protein homotetramerization [GO:0051289]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; suckling behavior [GO:0001967]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; synapse [GO:0045202]	glutaminase activity [GO:0004359]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; synapse [GO:0045202]; glutaminase activity [GO:0004359]; chemical synaptic transmission [GO:0007268]; glutamate biosynthetic process [GO:0006537]; glutamine catabolic process [GO:0006543]; intracellular glutamate homeostasis [GO:0090461]; protein homotetramerization [GO:0051289]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; suckling behavior [GO:0001967]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000250|UniProtKB:P13264}. Cytoplasm, cytosol {ECO:0000269|PubMed:22228304}. Note=The 74-kDa cytosolic precursor is translocated into the mitochondria and processed via a 72-kDa intermediate to yield the mature 68- and 65-kDa subunits. {ECO:0000250|UniProtKB:P13264}.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion {ECO:0000269|PubMed:22228304}.; SUBCELLULAR LOCATION: [Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix {ECO:0000250|UniProtKB:P13264}. Note=Produced by the proteolytic processing of the 74-kDa cytosolic precursor. {ECO:0000250|UniProtKB:P13264}.; SUBCELLULAR LOCATION: [Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix {ECO:0000250|UniProtKB:P13264}. Note=Produced by the proteolytic processing of the 74-kDa cytosolic precursor. {ECO:0000250|UniProtKB:P13264}.
O94927	reviewed	HAUS5_HUMAN	HAUS augmin-like complex subunit 5	HAUS5 KIAA0841	Homo sapiens (Human)	633	FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.		cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]		centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}.
O94929	reviewed	ABLM3_HUMAN	Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3)	ABLIM3 KIAA0843 HMFN1661	Homo sapiens (Human)	683	FUNCTION: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}.		cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; stress fiber [GO:0001725]	actin filament binding [GO:0051015]; metal ion binding [GO:0046872]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; stress fiber [GO:0001725]; actin filament binding [GO:0051015]; metal ion binding [GO:0046872]; cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O94933	reviewed	SLIK3_HUMAN	SLIT and NTRK-like protein 3	SLITRK3 KIAA0848	Homo sapiens (Human)	977	FUNCTION: Suppresses neurite outgrowth. {ECO:0000250}.		axonogenesis [GO:0007409]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; neurotransmitter-gated ion channel clustering [GO:0072578]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]; synaptic transmission, GABAergic [GO:0051932]; terminal button organization [GO:0072553]	cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic specialization membrane [GO:0099634]		cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic specialization membrane [GO:0099634]; axonogenesis [GO:0007409]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; neurotransmitter-gated ion channel clustering [GO:0072578]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]; synaptic transmission, GABAergic [GO:0051932]; terminal button organization [GO:0072553]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O94941	reviewed	RNF37_HUMAN	RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5)	UBOX5 KIAA0860 RNF37 UBCE7IP5 UIP5	Homo sapiens (Human)	541	FUNCTION: May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. {ECO:0000250|UniProtKB:Q925F4}.		protein polyubiquitination [GO:0000209]	focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-ubiquitin ligase activity [GO:0034450]	focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-ubiquitin ligase activity [GO:0034450]; protein polyubiquitination [GO:0000209]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11274149, ECO:0000269|PubMed:11435423}. Note=Enriched in nuclear bodies. {ECO:0000269|PubMed:11274149}.
O94953	reviewed	KDM4B_HUMAN	Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B)	KDM4B JHDM3B JMJD2B KIAA0876	Homo sapiens (Human)	1096	FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.		brain development [GO:0007420]; chromatin remodeling [GO:0006338]; regulation of gene expression [GO:0010468]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; metal ion binding [GO:0046872]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; metal ion binding [GO:0046872]; brain development [GO:0007420]; chromatin remodeling [GO:0006338]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:15927959}.
O94955	reviewed	RHBT3_HUMAN	Rho-related BTB domain-containing protein 3 (EC 3.6.1.-)	RHOBTB3 KIAA0878	Homo sapiens (Human)	611	FUNCTION: Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. {ECO:0000269|PubMed:19490898}.		male gonad development [GO:0008584]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of proteolysis [GO:0030162]; retrograde transport, endosome to Golgi [GO:0042147]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; trans-Golgi network membrane [GO:0032588]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; GTPase activity [GO:0003924]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; trans-Golgi network membrane [GO:0032588]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; GTPase activity [GO:0003924]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625]; male gonad development [GO:0008584]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of proteolysis [GO:0030162]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:19490898}.
O94956	reviewed	SO2B1_HUMAN	Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Organic anion transporting polypeptide 2B1) (OATP2B1) (Solute carrier family 21 member 9)	SLCO2B1 KIAA0880 OATP2B1 OATPB SLC21A9	Homo sapiens (Human)	709	FUNCTION: Mediates the Na(+)-independent transport of steroid sulfate conjugates and other specific organic anions (PubMed:10873595, PubMed:11159893, PubMed:11932330, PubMed:12724351, PubMed:14610227, PubMed:16908597, PubMed:18501590, PubMed:20507927, PubMed:22201122, PubMed:23531488, PubMed:25132355, PubMed:27576593, PubMed:26383540, PubMed:28408210, PubMed:29871943, PubMed:34628357). Responsible for the transport of estrone 3-sulfate (E1S) through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S) (PubMed:11932330, PubMed:12409283). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver (PubMed:11159893). Mediates the intestinal uptake of sulfated steroids (PubMed:12724351, PubMed:28408210). Mediates the uptake of the neurosteroids DHEA-S and pregnenolone sulfate (PregS) into the endothelial cells of the blood-brain barrier as the first step to enter the brain (PubMed:16908597, PubMed:25132355). Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May act as a heme transporter that promotes cellular iron availability via heme oxygenase/HMOX2 and independently of TFRC (PubMed:35714613). Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (PubMed:26383540). Mediates the uptake of other substrates such as prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), taurocholate, L-thyroxine, leukotriene C4 and thromboxane B2 (PubMed:10873595, PubMed:14610227, PubMed:19129463, Ref.24, PubMed:29871943). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:14610227, PubMed:19129463, PubMed:22201122). The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound (PubMed:19129463, PubMed:20507927, PubMed:26277985). Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions (PubMed:19129463). Cytoplasmic glutamate may also act as counteranion in the placenta (PubMed:26277985). An inwardly directed proton gradient has also been proposed as the driving force of E1S uptake with a (H(+):E1S) stoichiometry of (1:1) (PubMed:20507927). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:12724351, ECO:0000269|PubMed:14610227, ECO:0000269|PubMed:16908597, ECO:0000269|PubMed:18501590, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20507927, ECO:0000269|PubMed:22201122, ECO:0000269|PubMed:23531488, ECO:0000269|PubMed:25132355, ECO:0000269|PubMed:26277985, ECO:0000269|PubMed:26383540, ECO:0000269|PubMed:27576593, ECO:0000269|PubMed:29871943, ECO:0000269|PubMed:34628357, ECO:0000269|PubMed:35714613, ECO:0000269|Ref.24, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 3]: Has estrone 3-sulfate (E1S) transport activity comparable with the full-length isoform 1. {ECO:0000269|PubMed:23531488}.	MISCELLANEOUS: Most likely contributes to the oral absorption and the disposition of a wide range of drugs in the intestine and the liver (PubMed:10873595, PubMed:11159893, PubMed:12724351, PubMed:14610227, PubMed:23531488, PubMed:26277985, Ref.24, PubMed:27576593). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:12724351, ECO:0000269|PubMed:14610227, ECO:0000269|PubMed:23531488, ECO:0000269|PubMed:26277985, ECO:0000269|PubMed:27576593, ECO:0000269|Ref.24}.	heme catabolic process [GO:0042167]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; transmembrane transporter activity [GO:0022857]; heme catabolic process [GO:0042167]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25132355}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:28408210}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:12724351, ECO:0000269|PubMed:28408210}; Multi-pass membrane protein {ECO:0000305}. Note=Expressed at the basal membrane of hepatocytes, syncytiotrophoblast and Sertoli cells (PubMed:11159893, PubMed:11932330, PubMed:12409283, PubMed:35307651). Localized to the basolateral membrane of enterocytes (PubMed:28408210). Also found at the apical membrane of enterocytes (PubMed:12724351, PubMed:28408210). {ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:12724351, ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:35307651}.
O94964	reviewed	SOGA1_HUMAN	Protein SOGA1 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)]	SOGA1 C20orf117 KIAA0889 SOGA	Homo sapiens (Human)	1423	FUNCTION: Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. {ECO:0000250}.		insulin receptor signaling pathway [GO:0008286]; negative regulation of gluconeogenesis [GO:0045721]; regulation of autophagy [GO:0010506]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]		extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; insulin receptor signaling pathway [GO:0008286]; negative regulation of gluconeogenesis [GO:0045721]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: [C-terminal 80 kDa form]: Secreted {ECO:0000250}. Note=Secreted in primary hepatocyte-conditioned media. {ECO:0000250}.
O94966	reviewed	UBP19_HUMAN	Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9)	USP19 KIAA0891 ZMYND9	Homo sapiens (Human)	1318	FUNCTION: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. {ECO:0000269|PubMed:19465887, ECO:0000269|PubMed:21849505, ECO:0000269|PubMed:22128162, ECO:0000269|PubMed:22689415}.		negative regulation of skeletal muscle tissue development [GO:0048642]; positive regulation of cell cycle process [GO:0090068]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of cellular response to hypoxia [GO:1900037]; regulation of ERAD pathway [GO:1904292]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]	cysteine-type deubiquitinase activity [GO:0004843]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; cysteine-type deubiquitinase activity [GO:0004843]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872]; negative regulation of skeletal muscle tissue development [GO:0048642]; positive regulation of cell cycle process [GO:0090068]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of cellular response to hypoxia [GO:1900037]; regulation of ERAD pathway [GO:1904292]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19465887}; Single-pass membrane protein {ECO:0000269|PubMed:19465887}.
O94967	reviewed	WDR47_HUMAN	WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin)	WDR47 KIAA0893	Homo sapiens (Human)	919			adult locomotory behavior [GO:0008344]; anterior commissure morphogenesis [GO:0021960]; autophagy [GO:0006914]; cerebral cortex radial glia-guided migration [GO:0021801]; corpus callosum development [GO:0022038]; detection of hot stimulus involved in thermoception [GO:0120168]; microtubule cytoskeleton organization [GO:0000226]; motor behavior [GO:0061744]; negative regulation of microtubule depolymerization [GO:0007026]; neural precursor cell proliferation [GO:0061351]; neuronal stem cell population maintenance [GO:0097150]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]		cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; adult locomotory behavior [GO:0008344]; anterior commissure morphogenesis [GO:0021960]; autophagy [GO:0006914]; cerebral cortex radial glia-guided migration [GO:0021801]; corpus callosum development [GO:0022038]; detection of hot stimulus involved in thermoception [GO:0120168]; microtubule cytoskeleton organization [GO:0000226]; motor behavior [GO:0061744]; negative regulation of microtubule depolymerization [GO:0007026]; neural precursor cell proliferation [GO:0061351]; neuronal stem cell population maintenance [GO:0097150]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localization along microtubules is mediated by MAP1S. {ECO:0000250}.
O94972	reviewed	TRI37_HUMAN	E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37)	TRIM37 KIAA0898 MUL POB1	Homo sapiens (Human)	964	FUNCTION: E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042, ECO:0000269|PubMed:28724525}.	MISCELLANEOUS: Acts as a proto-oncogene via its ability to monoubiquinate 'Lys-119' of histone H2A (H2AK119Ub): overexpressed in a number of breast cancers and promotes transformation of cells by mediating silencing of tumor suppressor genes (PubMed:25470042). {ECO:0000269|PubMed:25470042}.	aggresome assembly [GO:0070842]; negative regulation of centriole replication [GO:0046600]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoubiquitination [GO:0051865]; protein import into peroxisome matrix [GO:0016558]; protein stabilization [GO:0050821]	aggresome [GO:0016235]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	chromatin binding [GO:0003682]; histone H2AK119 ubiquitin ligase activity [GO:0140862]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	aggresome [GO:0016235]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; chromatin binding [GO:0003682]; histone H2AK119 ubiquitin ligase activity [GO:0140862]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; aggresome assembly [GO:0070842]; negative regulation of centriole replication [GO:0046600]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoubiquitination [GO:0051865]; protein import into peroxisome matrix [GO:0016558]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:25470042}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15885686}. Peroxisome membrane {ECO:0000269|PubMed:11938494, ECO:0000269|PubMed:28724525}; Peripheral membrane protein {ECO:0000269|PubMed:28724525}. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269|PubMed:15885686}.
O94973	reviewed	AP2A2_HUMAN	AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)	AP2A2 ADTAB CLAPA2 HIP9 HYPJ KIAA0899	Homo sapiens (Human)	939	FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:12960147, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}.		clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; vesicle-mediated transport [GO:0016192]	AP-2 adaptor complex [GO:0030122]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; secretory granule membrane [GO:0030667]	clathrin adaptor activity [GO:0035615]; disordered domain specific binding [GO:0097718]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]	AP-2 adaptor complex [GO:0030122]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; secretory granule membrane [GO:0030667]; clathrin adaptor activity [GO:0035615]; disordered domain specific binding [GO:0097718]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P17427}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17427}; Cytoplasmic side {ECO:0000250|UniProtKB:P17427}. Membrane, coated pit {ECO:0000250|UniProtKB:P17427}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17427}; Cytoplasmic side {ECO:0000250|UniProtKB:P17427}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250|UniProtKB:P17427}.
O94979	reviewed	SC31A_HUMAN	Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein)	SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334	Homo sapiens (Human)	1220	FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}.		COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; response to calcium ion [GO:0051592]	COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; vesicle coat [GO:0030120]	calcium-dependent protein binding [GO:0048306]; structural molecule activity [GO:0005198]	COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; vesicle coat [GO:0030120]; calcium-dependent protein binding [GO:0048306]; structural molecule activity [GO:0005198]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:10788476, ECO:0000269|PubMed:16957052, ECO:0000269|PubMed:22358839, ECO:0000269|PubMed:27716508}; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:17428803}. Note=Associates with membranes in a GTP-dependent manner (By similarity). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:25201882, PubMed:28442536, PubMed:17428803). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:28442536}.
O94983	reviewed	CMTA2_HUMAN	Calmodulin-binding transcription activator 2	CAMTA2 KIAA0909	Homo sapiens (Human)	1202	FUNCTION: Transcription activator. May act as tumor suppressor. {ECO:0000269|PubMed:11925432}.		cardiac muscle hypertrophy in response to stress [GO:0014898]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; cardiac muscle hypertrophy in response to stress [GO:0014898]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:11925432}.
O94985	reviewed	CSTN1_HUMAN	Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)]	CLSTN1 CS1 KIAA0911	Homo sapiens (Human)	981	FUNCTION: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles (PubMed:21385839). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (PubMed:12972431). {ECO:0000250|UniProtKB:Q99JH7, ECO:0000250|UniProtKB:Q9EPL2, ECO:0000269|PubMed:12972431, ECO:0000269|PubMed:21385839}.; FUNCTION: [Soluble Alc-alpha]: As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding (PubMed:15037614). {ECO:0000305|PubMed:15037614}.; FUNCTION: [CTF1-alpha]: In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP (PubMed:15037614). {ECO:0000305|PubMed:15037614}.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neurotransmitter receptor transport to postsynaptic membrane [GO:0098969]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; regulation of cell growth [GO:0001558]; regulation of synapse maturation [GO:0090128]; vesicle-mediated transport in synapse [GO:0099003]	cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; postsynaptic endosome [GO:0098845]; postsynaptic membrane [GO:0045211]	amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; kinesin binding [GO:0019894]; X11-like protein binding [GO:0042988]	cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; postsynaptic endosome [GO:0098845]; postsynaptic membrane [GO:0045211]; amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; kinesin binding [GO:0019894]; X11-like protein binding [GO:0042988]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neurotransmitter receptor transport to postsynaptic membrane [GO:0098969]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; regulation of cell growth [GO:0001558]; regulation of synapse maturation [GO:0090128]; vesicle-mediated transport in synapse [GO:0099003]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9EPL2}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17332754}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:17332754, ECO:0000269|PubMed:21385839}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000269|PubMed:17332754}. Note=Localized in the postsynaptic membrane of both excitatory and inhibitory synapses. {ECO:0000250|UniProtKB:Q9EPL2}.; SUBCELLULAR LOCATION: [Soluble Alc-alpha]: Nucleus {ECO:0000269|PubMed:17332754}. Note=The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000269|PubMed:17332754}.
O94986	reviewed	CE152_HUMAN	Centrosomal protein of 152 kDa (Cep152)	CEP152 KIAA0912	Homo sapiens (Human)	1710	FUNCTION: Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}.		cell projection organization [GO:0030030]; centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; deuterosome [GO:0098536]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099]	protein kinase binding [GO:0019901]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; deuterosome [GO:0098536]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099]; protein kinase binding [GO:0019901]; cell projection organization [GO:0030030]; centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20598275, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973, ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:30804208}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26337392, ECO:0000269|PubMed:32060285}. Note=Colocalizes with CDK5RAP2, WDR62 and CEP63 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles (PubMed:21983783, PubMed:26297806). Localizes to the deuterosome (By similarity). Localizes to pericentriolar material (PCM) (PubMed:26337392). {ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26337392}.
O94989	reviewed	ARHGF_HUMAN	Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)	ARHGEF15 KIAA0915	Homo sapiens (Human)	841	FUNCTION: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}.		negative regulation of synapse maturation [GO:2000297]; positive regulation of stress fiber assembly [GO:0051496]; regulation of catalytic activity [GO:0050790]; regulation of postsynapse assembly [GO:0150052]; regulation of small GTPase mediated signal transduction [GO:0051056]; retina vasculature morphogenesis in camera-type eye [GO:0061299]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; negative regulation of synapse maturation [GO:2000297]; positive regulation of stress fiber assembly [GO:0051496]; regulation of catalytic activity [GO:0050790]; regulation of postsynapse assembly [GO:0150052]; regulation of small GTPase mediated signal transduction [GO:0051056]; retina vasculature morphogenesis in camera-type eye [GO:0061299]	SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000250}. Note=Expressed exclusively in dendrites of the developing hippocampus. {ECO:0000250}.
O94991	reviewed	SLIK5_HUMAN	SLIT and NTRK-like protein 5 (Leucine-rich repeat-containing protein 11)	SLITRK5 KIAA0918 LRRC11	Homo sapiens (Human)	958	FUNCTION: Suppresses neurite outgrowth. {ECO:0000250}.		adult behavior [GO:0030534]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; circulatory system development [GO:0072359]; dendrite morphogenesis [GO:0048813]; grooming behavior [GO:0007625]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; response to xenobiotic stimulus [GO:0009410]; skin development [GO:0043588]; striatum development [GO:0021756]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; synapse [GO:0045202]		plasma membrane [GO:0005886]; receptor complex [GO:0043235]; synapse [GO:0045202]; adult behavior [GO:0030534]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; circulatory system development [GO:0072359]; dendrite morphogenesis [GO:0048813]; grooming behavior [GO:0007625]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; response to xenobiotic stimulus [GO:0009410]; skin development [GO:0043588]; striatum development [GO:0021756]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O94992	reviewed	HEXI1_HUMAN	Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1)	HEXIM1 CLP1 EDG1 HIS1 MAQ1	Homo sapiens (Human)	359	FUNCTION: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}.	MISCELLANEOUS: Inhibits Tat activity which is required for HIV-1 transcription.	activation of innate immune response [GO:0002218]; heart development [GO:0007507]; innate immune response [GO:0045087]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of viral transcription [GO:0032897]; positive regulation of signal transduction by p53 class mediator [GO:1901798]	7SK snRNP [GO:0120259]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	7SK snRNA binding [GO:0097322]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; P-TEFb complex binding [GO:0106140]; protein kinase inhibitor activity [GO:0004860]; snRNA binding [GO:0017069]	7SK snRNP [GO:0120259]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 7SK snRNA binding [GO:0097322]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; P-TEFb complex binding [GO:0106140]; protein kinase inhibitor activity [GO:0004860]; snRNA binding [GO:0017069]; activation of innate immune response [GO:0002218]; heart development [GO:0007507]; innate immune response [GO:0045087]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of viral transcription [GO:0032897]; positive regulation of signal transduction by p53 class mediator [GO:1901798]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:12941847, ECO:0000269|PubMed:16362050, ECO:0000269|PubMed:17395637}. Cytoplasm {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:17395637}. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050).
O94993	reviewed	SOX30_HUMAN	Transcription factor SOX-30	SOX30	Homo sapiens (Human)	753	FUNCTION: Acts as both a transcriptional activator and repressor (PubMed:10359848, PubMed:29739711). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:10359848). Binds to its own promoter and activates its own transcription (By similarity). Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (PubMed:29739711). {ECO:0000250|UniProtKB:Q8CGW4, ECO:0000269|PubMed:10359848, ECO:0000269|PubMed:29739711}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proacrosomal vesicle fusion [GO:0120211]; regulation of transcription by RNA polymerase II [GO:0006357]; response to corticosteroid [GO:0031960]; spermatid development [GO:0007286]	chromatin [GO:0000785]; chromocenter [GO:0010369]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	beta-catenin binding [GO:0008013]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; chromocenter [GO:0010369]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; beta-catenin binding [GO:0008013]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proacrosomal vesicle fusion [GO:0120211]; regulation of transcription by RNA polymerase II [GO:0006357]; response to corticosteroid [GO:0031960]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10359848, ECO:0000269|PubMed:29739711}. Cytoplasm {ECO:0000269|PubMed:29739711}. Note=Enriched at the chromocenter. {ECO:0000250|UniProtKB:Q8CGW4}.
O95045	reviewed	UPP2_HUMAN	Uridine phosphorylase 2 (UPase 2) (UrdPase 2) (EC 2.4.2.3)	UPP2	Homo sapiens (Human)	317	FUNCTION: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:12849978, PubMed:21855639). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable). Shows broad substrate specificity and accepts uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates (PubMed:12849978). {ECO:0000269|PubMed:12849978, ECO:0000269|PubMed:21855639, ECO:0000305}.		dCMP catabolic process [GO:0006249]; nucleoside metabolic process [GO:0009116]; UMP salvage [GO:0044206]; uridine catabolic process [GO:0006218]; uridine metabolic process [GO:0046108]	cytosol [GO:0005829]; type III intermediate filament [GO:0045098]	deoxyuridine phosphorylase activity [GO:0047847]; identical protein binding [GO:0042802]; uridine phosphorylase activity [GO:0004850]	cytosol [GO:0005829]; type III intermediate filament [GO:0045098]; deoxyuridine phosphorylase activity [GO:0047847]; identical protein binding [GO:0042802]; uridine phosphorylase activity [GO:0004850]; dCMP catabolic process [GO:0006249]; nucleoside metabolic process [GO:0009116]; UMP salvage [GO:0044206]; uridine catabolic process [GO:0006218]; uridine metabolic process [GO:0046108]	
O95047	reviewed	OR2A4_HUMAN	Olfactory receptor 2A4 (Olfactory receptor 2A10) (Olfactory receptor OR6-37)	OR2A4 OR2A10	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; positive regulation of cytokinesis [GO:0032467]; regulation of actin cytoskeleton organization [GO:0032956]	cleavage furrow [GO:0032154]; Flemming body [GO:0090543]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; recycling endosome [GO:0055037]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	cleavage furrow [GO:0032154]; Flemming body [GO:0090543]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; recycling endosome [GO:0055037]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; positive regulation of cytokinesis [GO:0032467]; regulation of actin cytoskeleton organization [GO:0032956]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O95049	reviewed	ZO3_HUMAN	Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3)	TJP3 ZO3	Homo sapiens (Human)	919	FUNCTION: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}.		cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cell adhesion molecule binding [GO:0050839]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21411630}; Peripheral membrane protein {ECO:0000269|PubMed:21411630}; Cytoplasmic side {ECO:0000269|PubMed:21411630}. Cell junction, tight junction {ECO:0000269|PubMed:21411630, ECO:0000269|PubMed:23608536}. Nucleus {ECO:0000269|PubMed:23608536}. Note=Exhibits predominant nuclear expression in proliferating cells but is exclusively junctionally expressed after confluence is reached (PubMed:23608536). Shows an epithelial-specific tight junction localization in a TJP1/TJP2-dependent fashion (By similarity). {ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:23608536}.
O95050	reviewed	INMT_HUMAN	Indolethylamine N-methyltransferase (Indolamine N-methyltransferase) (EC 2.1.1.49) (EC 2.1.1.96) (Aromatic alkylamine N-methyltransferase) (Amine N-methyltransferase) (Arylamine N-methyltransferase) (Thioether S-methyltransferase) (TEMT)	INMT	Homo sapiens (Human)	263	FUNCTION: Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds. {ECO:0000250, ECO:0000269|PubMed:10552930}.		amine metabolic process [GO:0009308]; methylation [GO:0032259]; response to toxic substance [GO:0009636]	cytosol [GO:0005829]	amine N-methyltransferase activity [GO:0030748]; N-methyltransferase activity [GO:0008170]; S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity [GO:0102707]; thioether S-methyltransferase activity [GO:0004790]	cytosol [GO:0005829]; amine N-methyltransferase activity [GO:0030748]; N-methyltransferase activity [GO:0008170]; S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity [GO:0102707]; thioether S-methyltransferase activity [GO:0004790]; amine metabolic process [GO:0009308]; methylation [GO:0032259]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O95057	reviewed	DIRA1_HUMAN	GTP-binding protein Di-Ras1 (Distinct subgroup of the Ras family member 1) (Ras-related inhibitor of cell growth) (Rig) (Small GTP-binding tumor suppressor 1)	DIRAS1 GBTS1 RIG	Homo sapiens (Human)	198	FUNCTION: Displays low GTPase activity and exists predominantly in the GTP-bound form. {ECO:0000269|PubMed:12194967}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
O95059	reviewed	RPP14_HUMAN	Ribonuclease P protein subunit p14	RPP14	Homo sapiens (Human)	124	FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. {ECO:0000269|PubMed:10024167, ECO:0000269|PubMed:30454648}.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame. {ECO:0000269|PubMed:17898086}.	tRNA 5'-leader removal [GO:0001682]	multimeric ribonuclease P complex [GO:0030681]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]	multimeric ribonuclease P complex [GO:0030681]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; tRNA 5'-leader removal [GO:0001682]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10444065, ECO:0000305}.
O95067	reviewed	CCNB2_HUMAN	G2/mitotic-specific cyclin-B2	CCNB2	Homo sapiens (Human)	398	FUNCTION: Essential for the control of the cell cycle at the G2/M (mitosis) transition.		cell division [GO:0051301]; G2/MI transition of meiotic cell cycle [GO:0008315]; in utero embryonic development [GO:0001701]; mitotic cell cycle phase transition [GO:0044772]; regulation of growth [GO:0040008]; spindle assembly involved in female meiosis I [GO:0007057]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]	centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; cell division [GO:0051301]; G2/MI transition of meiotic cell cycle [GO:0008315]; in utero embryonic development [GO:0001701]; mitotic cell cycle phase transition [GO:0044772]; regulation of growth [GO:0040008]; spindle assembly involved in female meiosis I [GO:0007057]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]	
O95069	reviewed	KCNK2_HUMAN	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK-1) (Two pore potassium channel TPKC1)	KCNK2 TREK TREK1	Homo sapiens (Human)	426	FUNCTION: Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). {ECO:0000250|UniProtKB:P97438, ECO:0000269|PubMed:10784345, ECO:0000269|PubMed:11319556, ECO:0000269|PubMed:23169818}.; FUNCTION: [Isoform 4]: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2. {ECO:0000250}.	MISCELLANEOUS: Activated by volatile general anesthetics such as chloroform, halothane and isoflurane.	cardiac ventricle development [GO:0003231]; cellular response to hypoxia [GO:0071456]; cochlea development [GO:0090102]; G protein-coupled receptor signaling pathway [GO:0007186]; memory [GO:0007613]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of DNA biosynthetic process [GO:2000279]; positive regulation of cellular response to hypoxia [GO:1900039]; potassium ion transmembrane transport [GO:0071805]; response to axon injury [GO:0048678]; response to mechanical stimulus [GO:0009612]; stabilization of membrane potential [GO:0030322]	apical plasma membrane [GO:0016324]; astrocyte projection [GO:0097449]; calyx of Held [GO:0044305]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	outward rectifier potassium channel activity [GO:0015271]; potassium channel inhibitor activity [GO:0019870]; potassium ion leak channel activity [GO:0022841]	apical plasma membrane [GO:0016324]; astrocyte projection [GO:0097449]; calyx of Held [GO:0044305]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; outward rectifier potassium channel activity [GO:0015271]; potassium channel inhibitor activity [GO:0019870]; potassium ion leak channel activity [GO:0022841]; cardiac ventricle development [GO:0003231]; cellular response to hypoxia [GO:0071456]; cochlea development [GO:0090102]; G protein-coupled receptor signaling pathway [GO:0007186]; memory [GO:0007613]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of DNA biosynthetic process [GO:2000279]; positive regulation of cellular response to hypoxia [GO:1900039]; potassium ion transmembrane transport [GO:0071805]; response to axon injury [GO:0048678]; response to mechanical stimulus [GO:0009612]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:23169818}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:10784345}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
O95070	reviewed	YIF1A_HUMAN	Protein YIF1A (54TMp) (YIP1-interacting factor homolog A)	YIF1A 54TM HYIF1P YIF1	Homo sapiens (Human)	293	FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000269|PubMed:15990086}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]		COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15308636}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:15308636, ECO:0000269|PubMed:15990086, ECO:0000269|PubMed:26077767}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:26077767}; Multi-pass membrane protein {ECO:0000255}. Note=Cycles between the endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000269|PubMed:15308636}.
O95071	reviewed	UBR5_HUMAN	E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)	UBR5 EDD EDD1 HYD KIAA0896	Homo sapiens (Human)	2799	FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. {ECO:0000250, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692}.	MISCELLANEOUS: A cysteine residue is required for ubiquitin-thioester formation.	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of protein import into nucleus [GO:0042307]; progesterone receptor signaling pathway [GO:0050847]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of protein import into nucleus [GO:0042307]; progesterone receptor signaling pathway [GO:0050847]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]	SUBCELLULAR LOCATION: Nucleus.
O95072	reviewed	REC8_HUMAN	Meiotic recombination protein REC8 homolog (Cohesin Rec8p)	REC8 REC8L1	Homo sapiens (Human)	547	FUNCTION: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). {ECO:0000250}.		double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; fertilization [GO:0009566]; male meiosis I [GO:0007141]; meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177]; oocyte maturation [GO:0001556]; reciprocal meiotic recombination [GO:0007131]; seminiferous tubule development [GO:0072520]; sister chromatid cohesion [GO:0007062]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	cohesin complex [GO:0008278]; kinetochore [GO:0000776]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; meiotic cohesin complex [GO:0030893]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	cohesin complex [GO:0008278]; kinetochore [GO:0000776]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; meiotic cohesin complex [GO:0030893]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; fertilization [GO:0009566]; male meiosis I [GO:0007141]; meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177]; oocyte maturation [GO:0001556]; reciprocal meiotic recombination [GO:0007131]; seminiferous tubule development [GO:0072520]; sister chromatid cohesion [GO:0007062]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6AYJ4}. Chromosome {ECO:0000250|UniProtKB:Q6AYJ4}. Chromosome, centromere {ECO:0000250|UniProtKB:Q6AYJ4}. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II. Localized to centromeres and spindle poles in endopolyploid tumor cells. {ECO:0000250|UniProtKB:Q6AYJ4}.
O95073	reviewed	FSBP_HUMAN	Fibrinogen silencer-binding protein	FSBP	Homo sapiens (Human)	299	FUNCTION: Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1. {ECO:0000269|PubMed:20531236}.	MISCELLANEOUS: Intragenic, in the second intron of RAB54B gene.		nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20531236}.
O95096	reviewed	NKX22_HUMAN	Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B)	NKX2-2 NKX2.2 NKX2B	Homo sapiens (Human)	273	FUNCTION: Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). {ECO:0000250|UniProtKB:P42586}.		astrocyte differentiation [GO:0048708]; brain development [GO:0007420]; cell differentiation [GO:0030154]; digestive tract development [GO:0048565]; negative regulation of neuron differentiation [GO:0045665]; neuroendocrine cell differentiation [GO:0061101]; neuron fate specification [GO:0048665]; oligodendrocyte development [GO:0014003]; optic nerve development [GO:0021554]; pancreatic A cell fate commitment [GO:0003326]; pancreatic PP cell fate commitment [GO:0003329]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]; response to progesterone [GO:0032570]; smoothened signaling pathway [GO:0007224]; spinal cord motor neuron differentiation [GO:0021522]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; type B pancreatic cell development [GO:0003323]; type B pancreatic cell fate commitment [GO:0003327]; ventral spinal cord interneuron fate determination [GO:0060580]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; astrocyte differentiation [GO:0048708]; brain development [GO:0007420]; cell differentiation [GO:0030154]; digestive tract development [GO:0048565]; negative regulation of neuron differentiation [GO:0045665]; neuroendocrine cell differentiation [GO:0061101]; neuron fate specification [GO:0048665]; oligodendrocyte development [GO:0014003]; optic nerve development [GO:0021554]; pancreatic A cell fate commitment [GO:0003326]; pancreatic PP cell fate commitment [GO:0003329]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]; response to progesterone [GO:0032570]; smoothened signaling pathway [GO:0007224]; spinal cord motor neuron differentiation [GO:0021522]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; type B pancreatic cell development [GO:0003323]; type B pancreatic cell fate commitment [GO:0003327]; ventral spinal cord interneuron fate determination [GO:0060580]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
O95104	reviewed	SCAF4_HUMAN	SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15)	SCAF4 KIAA1172 SFRS15	Homo sapiens (Human)	1147	FUNCTION: Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF8, also acts as a suppressor of transcriptional readthrough (PubMed:31104839). {ECO:0000269|PubMed:31104839}.		negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000805]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000805]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31104839}.
O95125	reviewed	ZN202_HUMAN	Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10)	ZNF202 ZKSCAN10	Homo sapiens (Human)	648	FUNCTION: Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.		lipid metabolic process [GO:0006629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleolus [GO:0005730]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; lipid metabolic process [GO:0006629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
O95136	reviewed	S1PR2_HUMAN	Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (Endothelial differentiation G-protein coupled receptor 5) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5)	S1PR2 EDG5	Homo sapiens (Human)	353	FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). {ECO:0000250|UniProtKB:P47752, ECO:0000269|PubMed:10617617, ECO:0000269|PubMed:29453251}.		actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; excitatory postsynaptic potential [GO:0060079]; filopodium assembly [GO:0046847]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of excitatory postsynaptic potential [GO:0090394]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; regulation of metabolic process [GO:0019222]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; integrin binding [GO:0005178]; lipid binding [GO:0008289]; sphingosine-1-phosphate receptor activity [GO:0038036]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; integrin binding [GO:0005178]; lipid binding [GO:0008289]; sphingosine-1-phosphate receptor activity [GO:0038036]; actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; excitatory postsynaptic potential [GO:0060079]; filopodium assembly [GO:0046847]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of excitatory postsynaptic potential [GO:0090394]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; regulation of metabolic process [GO:0019222]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O95139	reviewed	NDUB6_HUMAN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (Complex I-B17) (CI-B17) (NADH-ubiquinone oxidoreductase B17 subunit)	NDUFB6	Homo sapiens (Human)	128	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
O95140	reviewed	MFN2_HUMAN	Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2)	MFN2 CPRP1 KIAA0214	Homo sapiens (Human)	757	FUNCTION: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:26214738, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). {ECO:0000250|UniProtKB:Q80U63, ECO:0000250|UniProtKB:Q8R500, ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:26085578, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:28114303, ECO:0000305}.		apoptotic process [GO:0006915]; blastocyst formation [GO:0001825]; camera-type eye morphogenesis [GO:0048593]; mitochondrial fusion [GO:0008053]; mitochondrial membrane organization [GO:0007006]; mitochondrion localization [GO:0051646]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of smooth muscle cell proliferation [GO:0048662]; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:0061734]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein localization to phagophore assembly site [GO:0034497]; protein targeting to mitochondrion [GO:0006626]; response to unfolded protein [GO:0006986]	cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; blastocyst formation [GO:0001825]; camera-type eye morphogenesis [GO:0048593]; mitochondrial fusion [GO:0008053]; mitochondrial membrane organization [GO:0007006]; mitochondrion localization [GO:0051646]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of smooth muscle cell proliferation [GO:0048662]; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:0061734]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein localization to phagophore assembly site [GO:0034497]; protein targeting to mitochondrion [GO:0006626]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12499352, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:26214738}; Multi-pass membrane protein {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12499352, ECO:0000269|PubMed:23620051}. Note=Colocalizes with BAX during apoptosis. {ECO:0000269|PubMed:12499352}.
O95147	reviewed	DUS14_HUMAN	Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48) (MKP-1-like protein tyrosine phosphatase) (MKP-L) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6)	DUSP14 MKP6	Homo sapiens (Human)	198	FUNCTION: Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. Plays a negative role in TCR signaling by dephosphorylating MAP3K7 adapter TAB1 leading to its inactivation (PubMed:24403530). {ECO:0000269|PubMed:24403530}.		dephosphorylation [GO:0016311]		MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; protein tyrosine phosphatase activity [GO:0004725]; RNA binding [GO:0003723]	MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; protein tyrosine phosphatase activity [GO:0004725]; RNA binding [GO:0003723]; dephosphorylation [GO:0016311]	
O95149	reviewed	SPN1_HUMAN	Snurportin-1 (RNA U transporter 1)	SNUPN RNUT1 SPN1	Homo sapiens (Human)	360	FUNCTION: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:9670026}.		protein import into nucleus [GO:0006606]; RNA import into nucleus [GO:0006404]; snRNA import into nucleus [GO:0061015]	cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	nuclear import signal receptor activity [GO:0061608]; RNA cap binding [GO:0000339]	cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; nuclear import signal receptor activity [GO:0061608]; RNA cap binding [GO:0000339]; protein import into nucleus [GO:0006606]; RNA import into nucleus [GO:0006404]; snRNA import into nucleus [GO:0061015]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472}. Cytoplasm {ECO:0000269|PubMed:12095920, ECO:0000269|PubMed:9670026, ECO:0000305|PubMed:10209022}. Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920). It is re-exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway (PubMed:10209022). {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:12095920}.
O95150	reviewed	TNF15_HUMAN	Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor) [Cleaved into: Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form]	TNFSF15 TL1 VEGI	Homo sapiens (Human)	251	FUNCTION: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. {ECO:0000269|PubMed:10597252, ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9872942}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; immune response [GO:0006955]; signal transduction [GO:0007165]	extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]	extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; immune response [GO:0006955]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}; Single-pass type II membrane protein {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 15, secreted form]: Secreted.
O95153	reviewed	RIMB1_HUMAN	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1)	TSPOAP1 BZRAP1 KIAA0612 RBP1 RIMBP1	Homo sapiens (Human)	1857				calyx of Held [GO:0044305]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]	benzodiazepine receptor binding [GO:0030156]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626]	calyx of Held [GO:0044305]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; benzodiazepine receptor binding [GO:0030156]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9915832}. Mitochondrion {ECO:0000269|PubMed:9915832}. Note=Preferentially expressed in the mitochondria in the presence of TSPO.
O95154	reviewed	ARK73_HUMAN	Aflatoxin B1 aldehyde reductase member 3 (EC 1.-.-.-) (AFB1 aldehyde reductase 2) (AFB1-AR 2)	AKR7A3 AFAR2	Homo sapiens (Human)	331	FUNCTION: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:18416522}.		cellular aldehyde metabolic process [GO:0006081]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]	aldo-keto reductase (NADP) activity [GO:0004033]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; aldo-keto reductase (NADP) activity [GO:0004033]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802]; cellular aldehyde metabolic process [GO:0006081]	SUBCELLULAR LOCATION: Cytoplasm.
O95155	reviewed	UBE4B_HUMAN	Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)	UBE4B HDNB1 KIAA0684 UFD2	Homo sapiens (Human)	1302	FUNCTION: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}.	MISCELLANEOUS: [Isoform 4]: Expressed exclusively in mature striated muscle cells. {ECO:0000305}.	granzyme-mediated apoptotic signaling pathway [GO:0008626]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; response to UV [GO:0009411]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	enzyme binding [GO:0019899]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; enzyme binding [GO:0019899]; ubiquitin-ubiquitin ligase activity [GO:0034450]; granzyme-mediated apoptotic signaling pathway [GO:0008626]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; response to UV [GO:0009411]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17369820}. Nucleus {ECO:0000250|UniProtKB:Q9ES00}.
O95159	reviewed	ZFPL1_HUMAN	Zinc finger protein-like 1 (Zinc finger protein MCG4)	ZFPL1	Homo sapiens (Human)	310	FUNCTION: Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130. {ECO:0000269|PubMed:18323775}.		regulation of DNA-templated transcription [GO:0006355]; vesicle-mediated transport [GO:0016192]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; regulation of DNA-templated transcription [GO:0006355]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:18323775}; Single-pass membrane protein {ECO:0000269|PubMed:18323775}.
O95163	reviewed	ELP1_HUMAN	Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150)	ELP1 IKAP IKBKAP	Homo sapiens (Human)	1332	FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059). {ECO:0000250|UniProtKB:Q06706, ECO:0000250|UniProtKB:Q7TT37, ECO:0000269|PubMed:9751059, ECO:0000303|PubMed:29332244}.		regulation of translation [GO:0006417]; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926]; tRNA wobble uridine modification [GO:0002098]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634]	protein self-association [GO:0043621]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634]; protein self-association [GO:0043621]; tRNA binding [GO:0000049]; regulation of translation [GO:0006417]; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926]; tRNA wobble uridine modification [GO:0002098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:22854966}. Nucleus {ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576}.
O95166	reviewed	GBRAP_HUMAN	Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)	GABARAP FLC3B HT004	Homo sapiens (Human)	117	FUNCTION: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:9892355). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:15169837, PubMed:20562859, PubMed:22948227). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538). Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction (PubMed:25684205). Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (PubMed:25684205). Involved in apoptosis (PubMed:15977068). {ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:15977068, ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:25684205, ECO:0000269|PubMed:31006538, ECO:0000269|PubMed:9892355}.		autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; chemical synaptic transmission [GO:0007268]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macroautophagy [GO:0016236]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; protein targeting [GO:0006605]; regulation of Rac protein signal transduction [GO:0035020]	actin cytoskeleton [GO:0015629]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; sperm midpiece [GO:0097225]; synapse [GO:0045202]	beta-tubulin binding [GO:0048487]; GABA receptor binding [GO:0050811]; microtubule binding [GO:0008017]; phosphatidylethanolamine binding [GO:0008429]; ubiquitin protein ligase binding [GO:0031625]	actin cytoskeleton [GO:0015629]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; sperm midpiece [GO:0097225]; synapse [GO:0045202]; beta-tubulin binding [GO:0048487]; GABA receptor binding [GO:0050811]; microtubule binding [GO:0008017]; phosphatidylethanolamine binding [GO:0008429]; ubiquitin protein ligase binding [GO:0031625]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; chemical synaptic transmission [GO:0007268]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macroautophagy [GO:0016236]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; protein targeting [GO:0006605]; regulation of Rac protein signal transduction [GO:0035020]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:12507496, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19056683}. Endomembrane system {ECO:0000250|UniProtKB:P60517}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P60517}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P60517}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P60517}. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:P60517, ECO:0000250|UniProtKB:Q9DCD6}.
O95167	reviewed	NDUA3_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (Complex I-B9) (CI-B9) (NADH-ubiquinone oxidoreductase B9 subunit)	NDUFA3	Homo sapiens (Human)	84	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000255}.
O95168	reviewed	NDUB4_HUMAN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (Complex I-B15) (CI-B15) (NADH-ubiquinone oxidoreductase B15 subunit)	NDUFB4	Homo sapiens (Human)	129	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to oxidative stress [GO:0006979]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
O95169	reviewed	NDUB8_HUMAN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (Complex I-ASHI) (CI-ASHI) (NADH-ubiquinone oxidoreductase ASHI subunit)	NDUFB8	Homo sapiens (Human)	186	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
O95171	reviewed	SCEL_HUMAN	Sciellin	SCEL	Homo sapiens (Human)	688	FUNCTION: May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.		embryo development ending in birth or egg hatching [GO:0009792]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; response to mechanical stimulus [GO:0009612]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]	metal ion binding [GO:0046872]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; metal ion binding [GO:0046872]; embryo development ending in birth or egg hatching [GO:0009792]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; response to mechanical stimulus [GO:0009612]	SUBCELLULAR LOCATION: Cytoplasm. Membrane. Note=May become cross-linked to membrane proteins by transglutaminase.
O95180	reviewed	CAC1H_HUMAN	Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2)	CACNA1H	Homo sapiens (Human)	2353	FUNCTION: Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}.		aldosterone biosynthetic process [GO:0032342]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; cellular response to hormone stimulus [GO:0032870]; cellular response to potassium ion [GO:0035865]; cortisol biosynthetic process [GO:0034651]; inorganic cation transmembrane transport [GO:0098662]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; positive regulation of acrosome reaction [GO:2000344]; regulation of heart contraction [GO:0008016]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]	membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]	high voltage-gated calcium channel activity [GO:0008331]; low voltage-gated calcium channel activity [GO:0008332]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110]; voltage-gated monoatomic ion channel activity [GO:0005244]	membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; high voltage-gated calcium channel activity [GO:0008331]; low voltage-gated calcium channel activity [GO:0008332]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110]; voltage-gated monoatomic ion channel activity [GO:0005244]; aldosterone biosynthetic process [GO:0032342]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; cellular response to hormone stimulus [GO:0032870]; cellular response to potassium ion [GO:0035865]; cortisol biosynthetic process [GO:0034651]; inorganic cation transmembrane transport [GO:0098662]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; positive regulation of acrosome reaction [GO:2000344]; regulation of heart contraction [GO:0008016]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755}; Multi-pass membrane protein {ECO:0000305}. Note=Interaction with STAC increases expression at the cell membrane. {ECO:0000269|PubMed:27149520}.
O95182	reviewed	NDUA7_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (Complex I-B14.5a) (CI-B14.5a) (NADH-ubiquinone oxidoreductase subunit B14.5a)	NDUFA7	Homo sapiens (Human)	113	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial translation [GO:0032543]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; structural constituent of ribosome [GO:0003735]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial translation [GO:0032543]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
O95183	reviewed	VAMP5_HUMAN	Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)	VAMP5 HSPC191	Homo sapiens (Human)	116	FUNCTION: May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.		cell differentiation [GO:0030154]; Golgi to plasma membrane protein transport [GO:0043001]; muscle organ development [GO:0007517]; skeletal muscle tissue development [GO:0007519]	cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; late endosome [GO:0005770]; organelle membrane [GO:0031090]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]		cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; late endosome [GO:0005770]; organelle membrane [GO:0031090]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cell differentiation [GO:0030154]; Golgi to plasma membrane protein transport [GO:0043001]; muscle organ development [GO:0007517]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Endomembrane system {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity). {ECO:0000250}.
O95185	reviewed	UNC5C_HUMAN	Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C)	UNC5C UNC5H3	Homo sapiens (Human)	931	FUNCTION: Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). {ECO:0000250|UniProtKB:O08747, ECO:0000250|UniProtKB:Q761X5, ECO:0000269|PubMed:28483977}.	MISCELLANEOUS: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers. {ECO:0000269|PubMed:12655055}.	anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; brain development [GO:0007420]; chemorepulsion of axon [GO:0061643]; dorsal root ganglion development [GO:1990791]; ectopic germ cell programmed cell death [GO:0035234]; positive regulation of apoptotic process [GO:0043065]; positive regulation of developmental process [GO:0051094]; positive regulation of reproductive process [GO:2000243]; regulation of neuron migration [GO:2001222]	cell surface [GO:0009986]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]	netrin receptor activity [GO:0005042]; netrin receptor activity involved in chemorepulsion [GO:0005043]; protein kinase binding [GO:0019901]; tubulin binding [GO:0015631]	cell surface [GO:0009986]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; netrin receptor activity [GO:0005042]; netrin receptor activity involved in chemorepulsion [GO:0005043]; protein kinase binding [GO:0019901]; tubulin binding [GO:0015631]; anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; brain development [GO:0007420]; chemorepulsion of axon [GO:0061643]; dorsal root ganglion development [GO:1990791]; ectopic germ cell programmed cell death [GO:0035234]; positive regulation of apoptotic process [GO:0043065]; positive regulation of developmental process [GO:0051094]; positive regulation of reproductive process [GO:2000243]; regulation of neuron migration [GO:2001222]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25419706}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000269|PubMed:25419706}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q761X5}. Cell projection, axon {ECO:0000250|UniProtKB:O08747}. Cell projection, dendrite {ECO:0000250|UniProtKB:O08747}. Cell projection, growth cone {ECO:0000250|UniProtKB:O08747}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O08747}. Cell projection, filopodium {ECO:0000250|UniProtKB:O08747}.
O95196	reviewed	CSPG5_HUMAN	Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C)	CSPG5 CALEB NGC	Homo sapiens (Human)	566	FUNCTION: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. {ECO:0000269|PubMed:15358134}.	MISCELLANEOUS: Different forms of various molecular weight have been observed. Such forms are possibly due to different levels of glycosylation, phosphorylation and/or protein cleavage (By similarity). {ECO:0000250}.	axon regeneration [GO:0031103]; cell projection morphogenesis [GO:0048858]; cytoskeleton organization [GO:0007010]; glial cell projection elongation [GO:0106091]; intracellular transport [GO:0046907]; nervous system development [GO:0007399]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of synaptic vesicle exocytosis [GO:2000300]	cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	growth factor activity [GO:0008083]	cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; growth factor activity [GO:0008083]; axon regeneration [GO:0031103]; cell projection morphogenesis [GO:0048858]; cytoskeleton organization [GO:0007010]; glial cell projection elongation [GO:0106091]; intracellular transport [GO:0046907]; nervous system development [GO:0007399]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of synaptic vesicle exocytosis [GO:2000300]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9ERQ6}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9ERQ6}. Synaptic cell membrane {ECO:0000250|UniProtKB:Q71M36}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q71M36}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q71M36}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q71M36}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q71M36}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q71M36}. Cell surface {ECO:0000250|UniProtKB:Q71M36}. Secreted {ECO:0000269|PubMed:25326458}. Note=In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi. Partially enriched in lipid rafts. {ECO:0000250|UniProtKB:Q71M36, ECO:0000250|UniProtKB:Q9ERQ6}.
O95197	reviewed	RTN3_HUMAN	Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII)	RTN3 ASYIP NSPL2	Homo sapiens (Human)	1032	FUNCTION: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}.		apoptotic process [GO:0006915]; brain development [GO:0007420]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network organization [GO:0071786]; negative regulation of amyloid-beta formation [GO:1902430]; neuron differentiation [GO:0030182]; vesicle-mediated transport [GO:0016192]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; apoptotic process [GO:0006915]; brain development [GO:0007420]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network organization [GO:0071786]; negative regulation of amyloid-beta formation [GO:1902430]; neuron differentiation [GO:0030182]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12811824, ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:16979658, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17182608, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:29117567, ECO:0000269|PubMed:34313226}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:16979658, ECO:0000269|PubMed:29117567}; Multi-pass membrane protein {ECO:0000255}.
O95198	reviewed	KLHL2_HUMAN	Kelch-like protein 2 (Actin-binding protein Mayven)	KLHL2	Homo sapiens (Human)	593	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation (PubMed:23838290). The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (PubMed:23838290). Plays a role in the reorganization of the actin cytoskeleton (PubMed:10397770). Promotes growth of cell projections in oligodendrocyte precursors (PubMed:15715669). {ECO:0000250|UniProtKB:Q8JZP3, ECO:0000269|PubMed:10397770, ECO:0000269|PubMed:15715669, ECO:0000269|PubMed:23838290}.		protein ubiquitination [GO:0016567]	actin cytoskeleton [GO:0015629]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; ruffle [GO:0001726]	actin binding [GO:0003779]; identical protein binding [GO:0042802]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	actin cytoskeleton [GO:0015629]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; ruffle [GO:0001726]; actin binding [GO:0003779]; identical protein binding [GO:0042802]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10397770, ECO:0000269|PubMed:15715669}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8JZP3}. Cell projection {ECO:0000269|PubMed:15715669}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:F1LZF0}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8JZP3}. Note=A proportion colocalizes with the actin cytoskeleton (PubMed:10397770). When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). {ECO:0000250|UniProtKB:Q8JZP3, ECO:0000269|PubMed:10397770}.
O95201	reviewed	RHIT_HUMAN	Transcriptional repressor RHIT (Repressor of heat-inducible transcription) (RhitH) (Zinc finger protein 205) (Zinc finger protein 210)	ZNF205 RHIT ZNF210	Homo sapiens (Human)	554	FUNCTION: Transcriptional repressor involved in regulating MPV17L expression (PubMed:22306510). By regulating MPV17L expression, contributes to the regulation of genes involved in H(2)O(2) metabolism and the mitochondrial apoptotic cascade (PubMed:22306510). {ECO:0000269|PubMed:22306510}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	mitochondrion [GO:0005739]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	mitochondrion [GO:0005739]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O95202	reviewed	LETM1_HUMAN	Mitochondrial proton/calcium exchanger protein (Electroneutral mitochondrial K(+)/H(+)exchanger) (KHE) (Leucine zipper-EF-hand-containing transmembrane protein 1)	LETM1	Homo sapiens (Human)	739	FUNCTION: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:18628306, PubMed:19797662, PubMed:24898248, PubMed:24344246, PubMed:29123128, PubMed:32139798, PubMed:36321428, PubMed:36055214). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662, PubMed:24344246, PubMed:29123128). Functions also as an electroneutral mitochondrial proton/potassium exchanger (PubMed:24898248, PubMed:36055214, PubMed:36321428). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306, PubMed:36055214). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306, PubMed:32139798). {ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:19797662, ECO:0000269|PubMed:24344246, ECO:0000269|PubMed:24898248, ECO:0000269|PubMed:29123128, ECO:0000269|PubMed:32139798, ECO:0000269|PubMed:36055214, ECO:0000269|PubMed:36321428}.	MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to intron retention. {ECO:0000305}.	calcium export from the mitochondrion [GO:0099093]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrial potassium ion transmembrane transport [GO:0140141]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260]; regulation of cellular hyperosmotic salinity response [GO:1900069]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	calcium ion binding [GO:0005509]; calcium:proton antiporter activity [GO:0015369]; ribosome binding [GO:0043022]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; calcium ion binding [GO:0005509]; calcium:proton antiporter activity [GO:0015369]; ribosome binding [GO:0043022]; calcium export from the mitochondrion [GO:0099093]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrial potassium ion transmembrane transport [GO:0140141]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260]; regulation of cellular hyperosmotic salinity response [GO:1900069]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:14706454, ECO:0000269|PubMed:15138253, ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:19797662, ECO:0000269|PubMed:32139798}; Single-pass membrane protein {ECO:0000255}.
O95206	reviewed	PCDH8_HUMAN	Protocadherin-8 (Arcadlin)	PCDH8	Homo sapiens (Human)	1070	FUNCTION: Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; modulation of chemical synaptic transmission [GO:0050804]; morphogenesis of embryonic epithelium [GO:0016331]; regulation of synaptic membrane adhesion [GO:0099179]; somitogenesis [GO:0001756]	dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]	calcium ion binding [GO:0005509]	dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; modulation of chemical synaptic transmission [GO:0050804]; morphogenesis of embryonic epithelium [GO:0016331]; regulation of synaptic membrane adhesion [GO:0099179]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Presynaptic cell membrane. Postsynaptic cell membrane. Note=Also expressed in neuronal cell bodies. Localized to excitatory, but not with inhibitory, synapses. {ECO:0000250}.
O95208	reviewed	EPN2_HUMAN	Epsin-2 (EPS-15-interacting protein 2)	EPN2 KIAA1065	Homo sapiens (Human)	641	FUNCTION: Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}.		endocytosis [GO:0006897]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of Notch signaling pathway [GO:0045747]	clathrin vesicle coat [GO:0030125]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543]	clathrin vesicle coat [GO:0030125]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543]; endocytosis [GO:0006897]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of Notch signaling pathway [GO:0045747]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10567358}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:10567358}. Note=In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.
O95210	reviewed	STBD1_HUMAN	Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1)	STBD1 GENX-3414	Homo sapiens (Human)	358	FUNCTION: Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}.		glycogen catabolic process [GO:0005980]; glycophagy [GO:0061723]; intracellular transport [GO:0046907]; substrate localization to autophagosome [GO:0061753]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site membrane [GO:0034045]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; tertiary granule membrane [GO:0070821]	cargo receptor activity [GO:0038024]; enzyme binding [GO:0019899]; glycogen binding [GO:2001069]; polysaccharide binding [GO:0030247]; starch binding [GO:2001070]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site membrane [GO:0034045]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; tertiary granule membrane [GO:0070821]; cargo receptor activity [GO:0038024]; enzyme binding [GO:0019899]; glycogen binding [GO:2001069]; polysaccharide binding [GO:0030247]; starch binding [GO:2001070]; glycogen catabolic process [GO:0005980]; glycophagy [GO:0061723]; intracellular transport [GO:0046907]; substrate localization to autophagosome [GO:0061753]	SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000269|PubMed:20810658, ECO:0000305|PubMed:21893048}; Single-pass type III membrane protein {ECO:0000305|PubMed:9794794}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24837458}; Single-pass type III membrane protein {ECO:0000305|PubMed:9794794}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:9794794}. Note=Also detected near the junctional sarcoplasmic reticulum (PubMed:9794794). Concentrates at perinuclear structures (PubMed:21893048). {ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:9794794}.
O95214	reviewed	LERL1_HUMAN	Leptin receptor overlapping transcript-like 1 (Endospanin-2)	LEPROTL1 My047 UNQ577/PRO1139	Homo sapiens (Human)	131	FUNCTION: Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269|PubMed:19907080}.		late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]	endosome [GO:0005768]; membrane [GO:0016020]	identical protein binding [GO:0042802]	endosome [GO:0005768]; membrane [GO:0016020]; identical protein binding [GO:0042802]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O95218	reviewed	ZRAB2_HUMAN	Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing)	ZRANB2 ZIS ZNF265	Homo sapiens (Human)	330	FUNCTION: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987}.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	nucleoplasm [GO:0005654]	lipopolysaccharide binding [GO:0001530]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; lipopolysaccharide binding [GO:0001530]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11448987}.
O95219	reviewed	SNX4_HUMAN	Sorting nexin-4	SNX4	Homo sapiens (Human)	450	FUNCTION: Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011). Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622). {ECO:0000269|PubMed:12668730, ECO:0000269|PubMed:17994011, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:33468622}.		endocytic recycling [GO:0032456]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic endosome [GO:0098830]; protein-containing complex [GO:0032991]; SNARE complex [GO:0031201]	epidermal growth factor receptor binding [GO:0005154]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]; transferrin receptor binding [GO:1990459]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic endosome [GO:0098830]; protein-containing complex [GO:0032991]; SNARE complex [GO:0031201]; epidermal growth factor receptor binding [GO:0005154]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]; transferrin receptor binding [GO:1990459]; endocytic recycling [GO:0032456]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:17994011, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:33468622}; Peripheral membrane protein {ECO:0000269|PubMed:17994011}; Cytoplasmic side {ECO:0000269|PubMed:17994011}. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC). {ECO:0000269|PubMed:17994011}.
O95229	reviewed	ZWINT_HUMAN	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1)	ZWINT	Homo sapiens (Human)	277	FUNCTION: Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. {ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000269|PubMed:16732327}.		cell division [GO:0051301]; establishment of localization in cell [GO:0051649]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinetochore [GO:0000776]; Knl1/Spc105 complex [GO:0180019]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinetochore [GO:0000776]; Knl1/Spc105 complex [GO:0180019]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; cell division [GO:0051301]; establishment of localization in cell [GO:0051649]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
O95231	reviewed	VENTX_HUMAN	Homeobox protein VENTX (VENT homeobox homolog) (VENT-like homeobox protein 2)	VENTX HPX42B VENTX2	Homo sapiens (Human)	258	FUNCTION: May be involved in ventralization.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O95232	reviewed	LC7L3_HUMAN	Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1)	LUC7L3 CREAP1 CROP O48	Homo sapiens (Human)	432	FUNCTION: Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mRNA splice site recognition [GO:0006376]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]	DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]; DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA splice site recognition [GO:0006376]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:10631324, ECO:0000269|PubMed:12565863}. Note=The subnuclear localization is affected by cisplatin.
O95235	reviewed	KI20A_HUMAN	Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6)	KIF20A MKLP2 RAB6KIFL	Homo sapiens (Human)	890	FUNCTION: Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}.		microtubule bundle formation [GO:0001578]; microtubule-based movement [GO:0007018]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]	Golgi apparatus [GO:0005794]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; spindle [GO:0005819]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; protein kinase binding [GO:0019901]	Golgi apparatus [GO:0005794]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; protein kinase binding [GO:0019901]; microtubule bundle formation [GO:0001578]; microtubule-based movement [GO:0007018]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:29357359}. Note=Localizes to the spindle midzone during anaphase and telophase. {ECO:0000269|PubMed:29357359}.
O95236	reviewed	APOL3_HUMAN	Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1)	APOL3	Homo sapiens (Human)	402	FUNCTION: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.		inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]	lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
O95237	reviewed	LRAT_HUMAN	Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase)	LRAT	Homo sapiens (Human)	230	FUNCTION: Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938). Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity). {ECO:0000250|UniProtKB:Q9JI60, ECO:0000269|PubMed:9920938, ECO:0000305|PubMed:9920938}.		cellular response to leukemia inhibitory factor [GO:1990830]; positive regulation of lipid transport [GO:0032370]; response to bacterium [GO:0009617]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]; vitamin A metabolic process [GO:0006776]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum [GO:0005791]	acyltransferase activity [GO:0016746]; lecithin:11-cis retinol acyltransferase activity [GO:0102279]; O-palmitoyltransferase activity [GO:0016416]; phosphatidylcholine-retinol O-acyltransferase activity [GO:0047173]; retinoic acid binding [GO:0001972]; retinol binding [GO:0019841]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum [GO:0005791]; acyltransferase activity [GO:0016746]; lecithin:11-cis retinol acyltransferase activity [GO:0102279]; O-palmitoyltransferase activity [GO:0016416]; phosphatidylcholine-retinol O-acyltransferase activity [GO:0047173]; retinoic acid binding [GO:0001972]; retinol binding [GO:0019841]; cellular response to leukemia inhibitory factor [GO:1990830]; positive regulation of lipid transport [GO:0032370]; response to bacterium [GO:0009617]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]; vitamin A metabolic process [GO:0006776]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Rough endoplasmic reticulum {ECO:0000250}. Endosome, multivesicular body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity). {ECO:0000250}.
O95238	reviewed	SPDEF_HUMAN	SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor)	SPDEF PDEF PSE	Homo sapiens (Human)	335	FUNCTION: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269|PubMed:10625666}.		epithelial cell fate commitment [GO:0072148]; glandular epithelial cell development [GO:0002068]; intestinal epithelial cell development [GO:0060576]; lung goblet cell differentiation [GO:0060480]; negative regulation of cell fate commitment [GO:0010454]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell fate commitment [GO:0010455]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; epithelial cell fate commitment [GO:0072148]; glandular epithelial cell development [GO:0002068]; intestinal epithelial cell development [GO:0060576]; lung goblet cell differentiation [GO:0060480]; negative regulation of cell fate commitment [GO:0010454]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell fate commitment [GO:0010455]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O95239	reviewed	KIF4A_HUMAN	Chromosome-associated kinesin KIF4A (Chromokinesin-A)	KIF4A KIF4	Homo sapiens (Human)	1232	FUNCTION: Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}.		anterograde axonal transport [GO:0008089]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; organelle organization [GO:0006996]; spindle elongation [GO:0051231]	axon cytoplasm [GO:1904115]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; midbody [GO:0030496]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; spindle microtubule [GO:0005876]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	axon cytoplasm [GO:1904115]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; midbody [GO:0030496]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; spindle microtubule [GO:0005876]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; anterograde axonal transport [GO:0008089]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; organelle organization [GO:0006996]; spindle elongation [GO:0051231]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:11736643}. Cytoplasm {ECO:0000269|PubMed:11736643}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:29848660}. Midbody {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:29848660}. Chromosome {ECO:0000269|PubMed:11736643, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:29848660}. Note=Associates with chromosomes at all stage of mitosis (PubMed:11736643, PubMed:15297875, PubMed:15625105). Chromatin localization is dependent on iron-sulfur cluster binding (PubMed:29848660). In anaphase, associates with the mitotic spindle midzone (PubMed:15297875). In telophase and cytokinesis, co-localizes with CIAO2B at the spindle midzone and midbody (PubMed:29848660, PubMed:15297875). Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase (PubMed:15297875, PubMed:15625105). Does not localize to the nucleolus (PubMed:11736643). {ECO:0000269|PubMed:11736643, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}.
O95243	reviewed	MBD4_HUMAN	Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase)	MBD4 MED1	Homo sapiens (Human)	580	FUNCTION: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000269|PubMed:10097147, ECO:0000269|PubMed:10930409}.	MISCELLANEOUS: [Isoform 4]: Possesses uracil DNA glycosylase but not thymine DNA glycosylase activity. {ECO:0000305}.	depyrimidination [GO:0045008]; DNA repair [GO:0006281]; response to estradiol [GO:0032355]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA N-glycosylase activity [GO:0019104]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; satellite DNA binding [GO:0003696]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA N-glycosylase activity [GO:0019104]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; satellite DNA binding [GO:0003696]; depyrimidination [GO:0045008]; DNA repair [GO:0006281]; response to estradiol [GO:0032355]	SUBCELLULAR LOCATION: Nucleus.
O95248	reviewed	MTMR5_HUMAN	Myotubularin-related protein 5 (Inactive phosphatidylinositol 3-phosphatase 5) (SET-binding factor 1) (Sbf1)	SBF1 MTMR5	Homo sapiens (Human)	1868	FUNCTION: Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location (PubMed:12668758). May function as a guanine nucleotide exchange factor (GEF) activating RAB28 (PubMed:20937701). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701). Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts (PubMed:9537414). {ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:9537414}.		protein dephosphorylation [GO:0006470]; spermatid development [GO:0007286]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]	guanyl-nucleotide exchange factor activity [GO:0005085]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein dephosphorylation [GO:0006470]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:20937701}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12668758}.
O95249	reviewed	GOSR1_HUMAN	Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28)	GOSR1 GS28	Homo sapiens (Human)	250	FUNCTION: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:21860593}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion [GO:0006906]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133]	SNAP receptor activity [GO:0005484]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133]; SNAP receptor activity [GO:0005484]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15728195, ECO:0000269|PubMed:17274796, ECO:0000269|PubMed:17337506, ECO:0000269|PubMed:21669198}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15728195, ECO:0000269|PubMed:17274796, ECO:0000269|PubMed:17337506, ECO:0000269|PubMed:21669198}. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius). {ECO:0000250}.
O95251	reviewed	KAT7_HUMAN	Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)	KAT7 HBO1 HBOa MYST2	Homo sapiens (Human)	611	FUNCTION: Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}.		DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication-dependent chromatin disassembly [GO:0140889]; internal peptidyl-lysine acetylation [GO:0018393]; natural killer cell differentiation [GO:0001779]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of DNA-templated transcription [GO:0006355]; regulation of nucleotide-excision repair [GO:2000819]; response to actinomycin D [GO:0072716]; response to anisomycin [GO:0072739]; response to dithiothreitol [GO:0072720]; response to hydroxyurea [GO:0072710]; response to sorbitol [GO:0072708]; stress-activated protein kinase signaling cascade [GO:0031098]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; histone H3-K14 acetyltransferase complex [GO:0036409]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	DNA replication origin binding [GO:0003688]; histone acetyltransferase activity [GO:0004402]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; histone H3-K14 acetyltransferase complex [GO:0036409]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; DNA replication origin binding [GO:0003688]; histone acetyltransferase activity [GO:0004402]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication-dependent chromatin disassembly [GO:0140889]; internal peptidyl-lysine acetylation [GO:0018393]; natural killer cell differentiation [GO:0001779]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of DNA-templated transcription [GO:0006355]; regulation of nucleotide-excision repair [GO:2000819]; response to actinomycin D [GO:0072716]; response to anisomycin [GO:0072739]; response to dithiothreitol [GO:0072720]; response to hydroxyurea [GO:0072710]; response to sorbitol [GO:0072708]; stress-activated protein kinase signaling cascade [GO:0031098]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10930412, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:28719581}. Chromosome {ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:28719581}. Chromosome, centromere {ECO:0000269|PubMed:27270040}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5SVQ0}. Note=Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067, PubMed:20129055). Localizes to transcription start sites (PubMed:21753189, PubMed:24065767). Localizes to ultraviolet-induced DNA damage sites following phosphorylation by ATR (PubMed:28719581). Localizes to centromeres in G1 phase (PubMed:27270040). {ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581}.
O95255	reviewed	MRP6_HUMAN	ATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6)	ABCC6 ARA MRP6	Homo sapiens (Human)	1503	FUNCTION: [Isoform 1]: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:11880368, PubMed:12414644). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed:12414644). {ECO:0000269|PubMed:11880368, ECO:0000269|PubMed:12414644, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 1]: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. {ECO:0000269|PubMed:24277820, ECO:0000269|PubMed:24969777}.; FUNCTION: [Isoform 2]: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. {ECO:0000269|PubMed:23912081}.	MISCELLANEOUS: [Isoform 3]: May function as a half transporter. {ECO:0000305}.	ATP metabolic process [GO:0046034]; ATP transport [GO:0015867]; calcium ion homeostasis [GO:0055074]; gene expression [GO:0010467]; inhibition of non-skeletal tissue mineralization [GO:0140928]; inorganic diphosphate transport [GO:0030505]; intracellular phosphate ion homeostasis [GO:0030643]; leukotriene transport [GO:0071716]; phosphate ion homeostasis [GO:0055062]; response to magnesium ion [GO:0032026]; response to sodium phosphate [GO:1904383]; response to xenobiotic stimulus [GO:0009410]; transmembrane transport [GO:0055085]; visual perception [GO:0007601]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP metabolic process [GO:0046034]; ATP transport [GO:0015867]; calcium ion homeostasis [GO:0055074]; gene expression [GO:0010467]; inhibition of non-skeletal tissue mineralization [GO:0140928]; inorganic diphosphate transport [GO:0030505]; intracellular phosphate ion homeostasis [GO:0030643]; leukotriene transport [GO:0071716]; phosphate ion homeostasis [GO:0055062]; response to magnesium ion [GO:0032026]; response to sodium phosphate [GO:1904383]; response to xenobiotic stimulus [GO:0009410]; transmembrane transport [GO:0055085]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the basal membrane of Sertoli cells. {ECO:0000269|PubMed:35307651}.; SUBCELLULAR LOCATION: [Isoform 1]: Basolateral cell membrane {ECO:0000269|PubMed:12901863, ECO:0000269|PubMed:23625951}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23912081}; Single-pass membrane protein {ECO:0000255}.
O95256	reviewed	I18RA_HUMAN	Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b)	IL18RAP IL1R7	Homo sapiens (Human)	599	FUNCTION: Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable). {ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:9792649, ECO:0000305|PubMed:10653850}.		cell population proliferation [GO:0008283]; cellular response to hydrogen peroxide [GO:0070301]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-18-mediated signaling pathway [GO:0035655]; neutrophil activation [GO:0042119]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]	interleukin-18 receptor complex [GO:0045092]; plasma membrane [GO:0005886]	coreceptor activity [GO:0015026]; interleukin-18 receptor activity [GO:0042008]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]	interleukin-18 receptor complex [GO:0045092]; plasma membrane [GO:0005886]; coreceptor activity [GO:0015026]; interleukin-18 receptor activity [GO:0042008]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; cell population proliferation [GO:0008283]; cellular response to hydrogen peroxide [GO:0070301]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-18-mediated signaling pathway [GO:0035655]; neutrophil activation [GO:0042119]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14528293}; Single-pass type I membrane protein {ECO:0000305}.
O95257	reviewed	GA45G_HUMAN	Growth arrest and DNA damage-inducible protein GADD45 gamma (Cytokine-responsive protein CR6) (DNA damage-inducible transcript 2 protein) (DDIT-2)	GADD45G CR6 DDIT2	Homo sapiens (Human)	159	FUNCTION: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.		apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of cell cycle [GO:0051726]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of cell cycle [GO:0051726]	
O95258	reviewed	UCP5_HUMAN	Brain mitochondrial carrier protein 1 (BMCP-1) (Mitochondrial uncoupling protein 5) (UCP 5) (Solute carrier family 25 member 14)	SLC25A14 BMCP1 UCP5 UNQ791/PRO1682	Homo sapiens (Human)	325	FUNCTION: Transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and glutamate and tricarboxylates (PubMed:31356773). May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide (Probable). Also can mediate a very low unidirectional transport of anions including sulfate, phosphate, (S)-malate, citrate, L-aspartate and L-glutamate (PubMed:31356773). Maintains oxidative balance (through uncoupling activities) and ATP production (by modifying mitochondrial membrane potential) (PubMed:20600837). Is able to transport protons across lipid membranes (PubMed:22524567, PubMed:26182433). Also exhibits transmembrane chloride transport activity to a lesser extent(PubMed:22524567, PubMed:26182433). May modify mitochondrial respiratory efficiency and mitochondrial oxidant production (By similarity). {ECO:0000250|UniProtKB:Q9Z2B2, ECO:0000269|PubMed:20600837, ECO:0000269|PubMed:22524567, ECO:0000269|PubMed:31356773, ECO:0000305|PubMed:31356773}.		aerobic respiration [GO:0009060]; inorganic anion transport [GO:0015698]; mitochondrial transport [GO:0006839]; regulation of cellular response to oxidative stress [GO:1900407]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	chloride transmembrane transporter activity [GO:0015108]; protein homodimerization activity [GO:0042803]; proton transmembrane transporter activity [GO:0015078]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; chloride transmembrane transporter activity [GO:0015108]; protein homodimerization activity [GO:0042803]; proton transmembrane transporter activity [GO:0015078]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857]; aerobic respiration [GO:0009060]; inorganic anion transport [GO:0015698]; mitochondrial transport [GO:0006839]; regulation of cellular response to oxidative stress [GO:1900407]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:20600837}; Multi-pass membrane protein {ECO:0000255}.
O95259	reviewed	KCNH1_HUMAN	Potassium voltage-gated channel subfamily H member 1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Voltage-gated potassium channel subunit Kv10.1)	KCNH1 EAG EAG1	Homo sapiens (Human)	989	FUNCTION: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). {ECO:0000269|PubMed:10880439, ECO:0000269|PubMed:11943152, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:23881642, ECO:0000269|PubMed:25556795, ECO:0000269|PubMed:27005320, ECO:0000269|PubMed:27325704, ECO:0000269|PubMed:27618660, ECO:0000269|PubMed:9738473}.		cellular response to calcium ion [GO:0071277]; myoblast fusion [GO:0007520]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of cell population proliferation [GO:0042127]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]	axon [GO:0030424]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; nuclear inner membrane [GO:0005637]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	calmodulin binding [GO:0005516]; delayed rectifier potassium channel activity [GO:0005251]; phosphatidylinositol bisphosphate binding [GO:1902936]	axon [GO:0030424]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; nuclear inner membrane [GO:0005637]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]; calmodulin binding [GO:0005516]; delayed rectifier potassium channel activity [GO:0005251]; phosphatidylinositol bisphosphate binding [GO:1902936]; cellular response to calcium ion [GO:0071277]; myoblast fusion [GO:0007520]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of cell population proliferation [GO:0042127]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10880439, ECO:0000269|PubMed:11943152, ECO:0000269|PubMed:21559285, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:25556795, ECO:0000269|PubMed:27005320, ECO:0000269|PubMed:27325704, ECO:0000269|PubMed:27618660, ECO:0000269|PubMed:9738473}; Multi-pass membrane protein {ECO:0000269|PubMed:21559285}. Nucleus inner membrane {ECO:0000269|PubMed:21559285}; Multi-pass membrane protein {ECO:0000269|PubMed:21559285}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63472}. Cell projection, axon {ECO:0000250|UniProtKB:Q63472}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q63472}. Perikaryon {ECO:0000250|UniProtKB:Q63472}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q63472}. Early endosome membrane {ECO:0000269|PubMed:22841712}. Note=Perinuclear KCNH1 is located to NPC-free islands.
O95263	reviewed	PDE8B_HUMAN	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein)	PDE8B PIG22	Homo sapiens (Human)	885	FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.	MISCELLANEOUS: [Isoform 1]: Major isoform.	behavioral fear response [GO:0001662]; cAMP catabolic process [GO:0006198]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of steroid hormone biosynthetic process [GO:0090032]; neuromuscular process controlling balance [GO:0050885]; operant conditioning [GO:0035106]; signal transduction [GO:0007165]; visual learning [GO:0008542]	cytosol [GO:0005829]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]; behavioral fear response [GO:0001662]; cAMP catabolic process [GO:0006198]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of steroid hormone biosynthetic process [GO:0090032]; neuromuscular process controlling balance [GO:0050885]; operant conditioning [GO:0035106]; signal transduction [GO:0007165]; visual learning [GO:0008542]	
O95264	reviewed	5HT3B_HUMAN	5-hydroxytryptamine receptor 3B (5-HT3-B) (5-HT3B) (Serotonin receptor 3B)	HTR3B	Homo sapiens (Human)	441	FUNCTION: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. {ECO:0000269|PubMed:10521471, ECO:0000269|PubMed:12867984, ECO:0000269|PubMed:17392525, ECO:0000269|PubMed:9950429}.		inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]	cell surface [GO:0009986]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; serotonin-gated monoatomic cation-selective channel activity [GO:0022850]	cell surface [GO:0009986]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; serotonin-gated monoatomic cation-selective channel activity [GO:0022850]; inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:9950429}; Multi-pass membrane protein {ECO:0000269|PubMed:21138434}. Cell membrane {ECO:0000269|PubMed:21138434}; Multi-pass membrane protein {ECO:0000269|PubMed:21138434}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. {ECO:0000269|PubMed:21138434}.
O95267	reviewed	GRP1_HUMAN	RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein)	RASGRP1 RASGRP	Homo sapiens (Human)	797	FUNCTION: Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types (PubMed:12845332). {ECO:0000250|UniProtKB:Q9Z1S3, ECO:0000269|PubMed:10807788, ECO:0000269|PubMed:12782630, ECO:0000269|PubMed:12839994, ECO:0000269|PubMed:12845332, ECO:0000269|PubMed:15060167, ECO:0000269|PubMed:15184873, ECO:0000269|PubMed:15899849, ECO:0000269|PubMed:19933860, ECO:0000269|PubMed:23908768, ECO:0000269|PubMed:27776107, ECO:0000269|PubMed:29155103}.		activation of GTPase activity [GO:0090630]; B cell activation [GO:0042113]; B cell proliferation [GO:0042100]; cell differentiation [GO:0030154]; inflammatory response to antigenic stimulus [GO:0002437]; mast cell degranulation [GO:0043303]; natural killer cell activation [GO:0030101]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of GTPase activity [GO:0043547]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; Ras protein signal transduction [GO:0007265]; regulation of ERK1 and ERK2 cascade [GO:0070372]; secretory granule localization [GO:0032252]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell proliferation [GO:0042098]; vesicle transport along microtubule [GO:0047496]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; phosphatidylcholine binding [GO:0031210]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; phosphatidylcholine binding [GO:0031210]; zinc ion binding [GO:0008270]; activation of GTPase activity [GO:0090630]; B cell activation [GO:0042113]; B cell proliferation [GO:0042100]; cell differentiation [GO:0030154]; inflammatory response to antigenic stimulus [GO:0002437]; mast cell degranulation [GO:0043303]; natural killer cell activation [GO:0030101]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of GTPase activity [GO:0043547]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; Ras protein signal transduction [GO:0007265]; regulation of ERK1 and ERK2 cascade [GO:0070372]; secretory granule localization [GO:0032252]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell proliferation [GO:0042098]; vesicle transport along microtubule [GO:0047496]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity). {ECO:0000250}.
O95271	reviewed	TNKS1_HUMAN	Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1)	TNKS PARP5A PARPL TIN1 TINF1 TNKS1	Homo sapiens (Human)	1327	FUNCTION: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379}.		cell division [GO:0051301]; mitotic spindle organization [GO:0007052]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; regulation of telomere maintenance via telomerase [GO:0032210]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]	histone binding [GO:0042393]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; zinc ion binding [GO:0008270]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; histone binding [GO:0042393]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; zinc ion binding [GO:0008270]; cell division [GO:0051301]; mitotic spindle organization [GO:0007052]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; regulation of telomere maintenance via telomerase [GO:0032210]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10523501, ECO:0000269|PubMed:21799911, ECO:0000269|PubMed:22864114}. Golgi apparatus membrane {ECO:0000269|PubMed:22864114}; Peripheral membrane protein {ECO:0000269|PubMed:22864114}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10523501, ECO:0000269|PubMed:21799911}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:10523501}. Chromosome, telomere {ECO:0000305|PubMed:9822378}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16076287}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles (PubMed:22864114). A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres (PubMed:10523501). During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1 (PubMed:12768206). Localizes to spindle poles at mitosis onset via interaction with NUMA1 (PubMed:12080061). {ECO:0000269|PubMed:10523501, ECO:0000269|PubMed:12080061, ECO:0000269|PubMed:12768206, ECO:0000269|PubMed:22864114}.
O95273	reviewed	CCDB1_HUMAN	Cyclin-D1-binding protein 1 (Grap2 and cyclin-D-interacting protein) (Human homolog of Maid)	CCNDBP1 DIP1 GCIP HHM	Homo sapiens (Human)	360	FUNCTION: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription. {ECO:0000269|PubMed:10801854}.		cell cycle [GO:0007049]; regulation of cell cycle [GO:0051726]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell cycle [GO:0007049]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
O95274	reviewed	LYPD3_HUMAN	Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4)	LYPD3 C4.4A UNQ491/PRO1007	Homo sapiens (Human)	346	FUNCTION: Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression. {ECO:0000269|PubMed:11179665, ECO:0000269|PubMed:11245483, ECO:0000269|PubMed:12592373, ECO:0000269|PubMed:15012588}.		cell-matrix adhesion [GO:0007160]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	laminin binding [GO:0043236]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; laminin binding [GO:0043236]; cell-matrix adhesion [GO:0007160]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
O95278	reviewed	EPM2A_HUMAN	Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase)	EPM2A	Homo sapiens (Human)	331	FUNCTION: Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:16901901, PubMed:23922729, PubMed:26231210, PubMed:25538239, PubMed:25544560). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:11001928, PubMed:11220751, PubMed:11739371, PubMed:14532330, PubMed:16971387, PubMed:18617530, PubMed:22036712, PubMed:23922729, PubMed:14722920). Has been shown to dephosphorylate MAPT (By similarity). Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin (PubMed:23922729). Also promotes proteasome-independent protein degradation through the macroautophagy pathway (PubMed:20453062). {ECO:0000250|UniProtKB:Q9WUA5, ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:11220751, ECO:0000269|PubMed:11739371, ECO:0000269|PubMed:14532330, ECO:0000269|PubMed:14722920, ECO:0000269|PubMed:16901901, ECO:0000269|PubMed:16971387, ECO:0000269|PubMed:18070875, ECO:0000269|PubMed:18617530, ECO:0000269|PubMed:19036738, ECO:0000269|PubMed:20453062, ECO:0000269|PubMed:22036712, ECO:0000269|PubMed:23624058, ECO:0000269|PubMed:23922729, ECO:0000269|PubMed:25538239, ECO:0000269|PubMed:25544560, ECO:0000269|PubMed:26231210}.; FUNCTION: [Isoform 2]: Does not bind to glycogen (PubMed:18617530). Lacks phosphatase activity and might function as a dominant-negative regulator for the phosphatase activity of isoform 1 and isoform 7 (PubMed:18617530, PubMed:22036712). {ECO:0000269|PubMed:18617530, ECO:0000269|PubMed:22036712}.; FUNCTION: [Isoform 7]: Has phosphatase activity (in vitro). {ECO:0000269|PubMed:22036712}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing. May be due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative initiation at Met-244 of isoform 1. Transcript amplified but protein not detected. {ECO:0000269|PubMed:22036712}.; MISCELLANEOUS: [Isoform 7]: Produced by alternative splicing. Active phosphatase. {ECO:0000269|PubMed:22036712}.; MISCELLANEOUS: [Isoform 8]: Produced by alternative splicing. {ECO:0000305}.	autophagosome assembly [GO:0000045]; calcium ion transport [GO:0006816]; carbohydrate phosphorylation [GO:0046835]; dephosphorylation [GO:0016311]; glial cell proliferation [GO:0014009]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; habituation [GO:0046959]; L-glutamate transmembrane transport [GO:0015813]; mitochondrion organization [GO:0007005]; negative regulation of cell cycle [GO:0045786]; negative regulation of dephosphorylation [GO:0035305]; negative regulation of gene expression [GO:0010629]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of phosphatase activity [GO:0010923]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of macroautophagy [GO:0016239]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; regulation of cell growth [GO:0001558]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein import into nucleus [GO:0042306]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein ubiquitination [GO:0031396]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; carbohydrate phosphatase activity [GO:0019203]; glycogen (starch) synthase activity [GO:0004373]; glycogen binding [GO:2001069]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; starch binding [GO:2001070]	cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; carbohydrate phosphatase activity [GO:0019203]; glycogen (starch) synthase activity [GO:0004373]; glycogen binding [GO:2001069]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; starch binding [GO:2001070]; autophagosome assembly [GO:0000045]; calcium ion transport [GO:0006816]; carbohydrate phosphorylation [GO:0046835]; dephosphorylation [GO:0016311]; glial cell proliferation [GO:0014009]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; habituation [GO:0046959]; L-glutamate transmembrane transport [GO:0015813]; mitochondrion organization [GO:0007005]; negative regulation of cell cycle [GO:0045786]; negative regulation of dephosphorylation [GO:0035305]; negative regulation of gene expression [GO:0010629]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of phosphatase activity [GO:0010923]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of macroautophagy [GO:0016239]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; regulation of cell growth [GO:0001558]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein import into nucleus [GO:0042306]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein ubiquitination [GO:0031396]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:11220751, ECO:0000269|PubMed:11739371, ECO:0000269|PubMed:15102711, ECO:0000269|PubMed:17908927}. Note=Under glycogenolytic conditions localizes to the nucleus. {ECO:0000269|PubMed:17908927}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:11739371, ECO:0000269|PubMed:11883934, ECO:0000269|PubMed:14532330, ECO:0000269|PubMed:18311786, ECO:0000269|PubMed:18617530, ECO:0000269|PubMed:22036712}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:14722920, ECO:0000269|PubMed:18311786}; Peripheral membrane protein {ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:18311786}; Cytoplasmic side {ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:18311786}. Cell membrane {ECO:0000269|PubMed:11220751}. Note=Colocalizes with glycogen synthase in punctate structures in the cytoplasm (PubMed:11739371, PubMed:14532330). Primarily associated with polyribosomes at the rough endoplasmic reticulum, and also detected at the plasma membrane (PubMed:11001928, PubMed:11220751, PubMed:11883934, PubMed:18311786). {ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:11220751, ECO:0000269|PubMed:11739371, ECO:0000269|PubMed:11883934, ECO:0000269|PubMed:14532330, ECO:0000269|PubMed:18311786}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:18617530}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11883934}; Peripheral membrane protein {ECO:0000269|PubMed:11883934}; Cytoplasmic side {ECO:0000269|PubMed:11883934}. Cell membrane {ECO:0000269|PubMed:11883934}. Nucleus {ECO:0000269|PubMed:11883934, ECO:0000269|PubMed:14722920, ECO:0000269|PubMed:18617530}. Note=Also found in the nucleus. {ECO:0000269|PubMed:11883934, ECO:0000269|PubMed:18617530}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:22036712}. Nucleus {ECO:0000269|PubMed:22036712}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:22036712}. Nucleus {ECO:0000269|PubMed:22036712}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm {ECO:0000269|PubMed:22036712}.
O95279	reviewed	KCNK5_HUMAN	Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2)	KCNK5 TASK2	Homo sapiens (Human)	499	FUNCTION: pH-dependent, outwardly rectifying potassium channel (PubMed:9812978). Outward rectification is lost at high external K(+) concentrations (PubMed:9812978). {ECO:0000269|PubMed:9812978}.	MISCELLANEOUS: Inhibited by quinine, quinidine and external acidification. {ECO:0000269|PubMed:9812978}.	potassium ion export across plasma membrane [GO:0097623]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of resting membrane potential [GO:0060075]; stabilization of membrane potential [GO:0030322]	plasma membrane [GO:0005886]	outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; potassium ion export across plasma membrane [GO:0097623]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of resting membrane potential [GO:0060075]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O95292	reviewed	VAPB_HUMAN	Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)	VAPB UNQ484/PRO983	Homo sapiens (Human)	243	FUNCTION: Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and late endosomes via interaction with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732). Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, PubMed:20940299). Involved in cellular calcium homeostasis regulation (PubMed:22131369). {ECO:0000269|PubMed:16891305, ECO:0000269|PubMed:20940299, ECO:0000269|PubMed:22131369, ECO:0000269|PubMed:33124732}.		cholesterol transport [GO:0030301]; COPII-coated vesicle budding [GO:0090114]; endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum unfolded protein response [GO:0030968]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; intracellular calcium ion homeostasis [GO:0006874]; IRE1-mediated unfolded protein response [GO:0036498]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation by virus of viral protein levels in host cell [GO:0046725]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of viral genome replication [GO:0045070]; suppression of viral release by host [GO:0044790]; viral release from host cell [GO:0019076]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; FFAT motif binding [GO:0033149]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; FFAT motif binding [GO:0033149]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; cholesterol transport [GO:0030301]; COPII-coated vesicle budding [GO:0090114]; endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum unfolded protein response [GO:0030968]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; intracellular calcium ion homeostasis [GO:0006874]; IRE1-mediated unfolded protein response [GO:0036498]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation by virus of viral protein levels in host cell [GO:0046725]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of viral genome replication [GO:0045070]; suppression of viral release by host [GO:0044790]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:33124732}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9P0L0}. Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. {ECO:0000269|PubMed:22131369}.
O95294	reviewed	RASL1_HUMAN	RasGAP-activating-like protein 1 (RAS protein activator like 1) (Ras GTPase-activating-like protein)	RASAL1 RASAL	Homo sapiens (Human)	804	FUNCTION: Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:9751798}.		cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of dendrite extension [GO:1903861]; signal transduction [GO:0007165]	cytosol [GO:0005829]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of dendrite extension [GO:1903861]; signal transduction [GO:0007165]	
O95295	reviewed	SNAPN_HUMAN	SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein)	SNAPIN BLOC1S7 SNAP25BP SNAPAP	Homo sapiens (Human)	136	FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:18167355, ECO:0000269|PubMed:25898167}.		anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; autophagosome maturation [GO:0097352]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; late endosome to lysosome transport [GO:1902774]; lysosomal lumen acidification [GO:0007042]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; melanosome organization [GO:0032438]; negative regulation of neuron projection development [GO:0010977]; neuron cellular homeostasis [GO:0070050]; neuron projection development [GO:0031175]; neurotransmitter secretion [GO:0007269]; organelle transport along microtubule [GO:0072384]; positive regulation of late endosome to lysosome transport [GO:1902824]; protein maturation [GO:0051604]; protein-containing complex localization [GO:0031503]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]; regulation of protein binding [GO:0043393]; regulation of synaptic vesicle exocytosis [GO:2000300]; retrograde axonal transport [GO:0008090]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle transport [GO:0048489]; terminal button organization [GO:0072553]	acrosomal vesicle [GO:0001669]; axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; manchette [GO:0002177]; perinuclear region of cytoplasm [GO:0048471]; secretory granule [GO:0030141]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	SNARE binding [GO:0000149]	acrosomal vesicle [GO:0001669]; axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; manchette [GO:0002177]; perinuclear region of cytoplasm [GO:0048471]; secretory granule [GO:0030141]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; SNARE binding [GO:0000149]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; autophagosome maturation [GO:0097352]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; late endosome to lysosome transport [GO:1902774]; lysosomal lumen acidification [GO:0007042]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; melanosome organization [GO:0032438]; negative regulation of neuron projection development [GO:0010977]; neuron cellular homeostasis [GO:0070050]; neuron projection development [GO:0031175]; neurotransmitter secretion [GO:0007269]; organelle transport along microtubule [GO:0072384]; positive regulation of late endosome to lysosome transport [GO:1902824]; protein maturation [GO:0051604]; protein-containing complex localization [GO:0031503]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]; regulation of protein binding [GO:0043393]; regulation of synaptic vesicle exocytosis [GO:2000300]; retrograde axonal transport [GO:0008090]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle transport [GO:0048489]; terminal button organization [GO:0072553]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9Z266}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z266}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z266}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z266}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18167355, ECO:0000269|PubMed:19168546, ECO:0000269|PubMed:21102408}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Z266}. Lysosome membrane {ECO:0000305|PubMed:25898167}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305|PubMed:21102408}. Note=Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells. {ECO:0000269|PubMed:19168546}.
O95297	reviewed	MPZL1_HUMAN	Myelin protein zero-like protein 1 (Protein zero-related)	MPZL1 PZR UNQ849/PRO1787	Homo sapiens (Human)	269	FUNCTION: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}.		cell-cell signaling [GO:0007267]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cell surface [GO:0009986]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	cell surface [GO:0009986]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]; cell-cell signaling [GO:0007267]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O95298	reviewed	NDUC2_HUMAN	NADH dehydrogenase [ubiquinone] 1 subunit C2 (Complex I-B14.5b) (CI-B14.5b) (Human lung cancer oncogene 1 protein) (HLC-1) (NADH-ubiquinone oxidoreductase subunit B14.5b)	NDUFC2 HLC1	Homo sapiens (Human)	119	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:32969598}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
O95299	reviewed	NDUAA_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit)	NDUFA10	Homo sapiens (Human)	355	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:12611891}.
O95302	reviewed	FKBP9_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP9 (PPIase FKBP9) (EC 5.2.1.8) (63 kDa FK506-binding protein) (63 kDa FKBP) (FKBP-63) (FK506-binding protein 9) (FKBP-9) (Rotamase)	FKBP9 FKBP60 FKBP63	Homo sapiens (Human)	570	FUNCTION: PPIases accelerate the folding of proteins during protein synthesis.		protein folding [GO:0006457]	endoplasmic reticulum [GO:0005783]	calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum [GO:0005783]; calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138}.
O95319	reviewed	CELF2_HUMAN	CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (Neuroblastoma apoptosis-related RNA-binding protein) (hNAPOR) (RNA-binding protein BRUNOL-3)	CELF2 BRUNOL3 CUGBP2 ETR3 NAPOR	Homo sapiens (Human)	508	FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250|UniProtKB:Q9Z0H4, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:11577082, ECO:0000269|PubMed:11931771, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:14973222, ECO:0000269|PubMed:15657417, ECO:0000269|PubMed:15894795, ECO:0000269|PubMed:28431233}.		mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of heart contraction [GO:0008016]; RNA processing [GO:0006396]	cytoplasm [GO:0005737]; Flemming body [GO:0090543]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; Flemming body [GO:0090543]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of heart contraction [GO:0008016]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33131106}. Cytoplasm {ECO:0000250|UniProtKB:Q7T2T1, ECO:0000250|UniProtKB:Q9Z0H4}. Note=Accumulates in the cytoplasm after ionizing radiation (By similarity). Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments. {ECO:0000250}.
O95340	reviewed	PAPS2_HUMAN	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]	PAPSS2 ATPSK2	Homo sapiens (Human)	614	FUNCTION: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases (PubMed:19474428, PubMed:11773860, PubMed:23824674, PubMed:25594860). In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway (PubMed:19474428, PubMed:11773860, PubMed:23824674, PubMed:25594860). Plays indirectly an important role in skeletogenesis during postnatal growth (PubMed:9771708). {ECO:0000269|PubMed:11773860, ECO:0000269|PubMed:19474428, ECO:0000269|PubMed:23824674, ECO:0000269|PubMed:25594860, ECO:0000269|PubMed:9771708}.		3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; blood coagulation [GO:0007596]; bone development [GO:0060348]; hormone metabolic process [GO:0042445]; phosphorylation [GO:0016310]; sulfate assimilation [GO:0000103]	cytosol [GO:0005829]	adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; sulfate adenylyltransferase (ATP) activity [GO:0004781]	cytosol [GO:0005829]; adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; sulfate adenylyltransferase (ATP) activity [GO:0004781]; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; blood coagulation [GO:0007596]; bone development [GO:0060348]; hormone metabolic process [GO:0042445]; phosphorylation [GO:0016310]; sulfate assimilation [GO:0000103]	
O95342	reviewed	ABCBB_HUMAN	Bile salt export pump (EC 7.6.2.-) (ATP-binding cassette sub-family B member 11)	ABCB11 BSEP	Homo sapiens (Human)	1321	FUNCTION: Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:16332456, PubMed:22262466, PubMed:15791618, PubMed:18985798, PubMed:19228692, PubMed:20398791, PubMed:24711118, PubMed:29507376, PubMed:20010382, PubMed:32203132). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (PubMed:15901796, PubMed:18245269). {ECO:0000269|PubMed:15791618, ECO:0000269|PubMed:15901796, ECO:0000269|PubMed:16332456, ECO:0000269|PubMed:18245269, ECO:0000269|PubMed:18985798, ECO:0000269|PubMed:19228692, ECO:0000269|PubMed:20010382, ECO:0000269|PubMed:20398791, ECO:0000269|PubMed:22262466, ECO:0000269|PubMed:24711118, ECO:0000269|PubMed:29507376, ECO:0000269|PubMed:32203132}.		bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; bile acid signaling pathway [GO:0038183]; canalicular bile acid transport [GO:0015722]; cholesterol homeostasis [GO:0042632]; fatty acid metabolic process [GO:0006631]; lipid homeostasis [GO:0055088]; phospholipid homeostasis [GO:0055091]; positive regulation of bile acid secretion [GO:0120189]; protein ubiquitination [GO:0016567]; regulation of bile acid metabolic process [GO:1904251]; regulation of fatty acid beta-oxidation [GO:0031998]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; transmembrane transport [GO:0055085]; xenobiotic export from cell [GO:0046618]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; intercellular canaliculus [GO:0046581]; intracellular canaliculus [GO:0046691]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]	ABC-type bile acid transporter activity [GO:0015432]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bile acid transmembrane transporter activity [GO:0015125]; canalicular bile acid transmembrane transporter activity [GO:0015126]; carbohydrate transmembrane transporter activity [GO:0015144]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; intercellular canaliculus [GO:0046581]; intracellular canaliculus [GO:0046691]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; ABC-type bile acid transporter activity [GO:0015432]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bile acid transmembrane transporter activity [GO:0015125]; canalicular bile acid transmembrane transporter activity [GO:0015126]; carbohydrate transmembrane transporter activity [GO:0015144]; bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; bile acid signaling pathway [GO:0038183]; canalicular bile acid transport [GO:0015722]; cholesterol homeostasis [GO:0042632]; fatty acid metabolic process [GO:0006631]; lipid homeostasis [GO:0055088]; phospholipid homeostasis [GO:0055091]; positive regulation of bile acid secretion [GO:0120189]; protein ubiquitination [GO:0016567]; regulation of bile acid metabolic process [GO:1904251]; regulation of fatty acid beta-oxidation [GO:0031998]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; transmembrane transport [GO:0055085]; xenobiotic export from cell [GO:0046618]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:15791618, ECO:0000269|PubMed:22262466}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:O70127}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O70127}. Endosome {ECO:0000250|UniProtKB:O70127}. Cell membrane {ECO:0000269|PubMed:20010382, ECO:0000269|PubMed:22262466, ECO:0000269|PubMed:29507376, ECO:0000269|PubMed:30431138}; Multi-pass membrane protein {ECO:0000255}. Note=Internalized at the canalicular membrane through interaction with the adapter protein complex 2 (AP-2) (PubMed:22262466). At steady state, localizes in the canalicular membrane but is also present in recycling endosomes. ABCB11 constantly and rapidly exchanges between the two sites through tubulo-vesicles carriers that move along microtubules. Microtubule-dependent trafficking of ABCB11 is enhanced by taurocholate and cAMP and regulated by STK11 through a PKA-mediated pathway. Trafficking of newly synthesized ABCB11 through endosomal compartment to the bile canalicular membrane is accelerated by cAMP but not by taurocholate (By similarity). Cell membrane expression is up-regulated by short- and medium-chain fatty acids (PubMed:20398791). {ECO:0000250|UniProtKB:O70127, ECO:0000269|PubMed:20398791, ECO:0000269|PubMed:22262466}.
O95343	reviewed	SIX3_HUMAN	Homeobox protein SIX3 (Sine oculis homeobox homolog 3)	SIX3	Homo sapiens (Human)	332	FUNCTION: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 and CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway. {ECO:0000250|UniProtKB:Q62233, ECO:0000269|PubMed:18791198}.		apoptotic process involved in development [GO:1902742]; brain development [GO:0007420]; cell proliferation in forebrain [GO:0021846]; epithelial cell maturation [GO:0002070]; eye development [GO:0001654]; forebrain dorsal/ventral pattern formation [GO:0021798]; lens development in camera-type eye [GO:0002088]; lens fiber cell apoptotic process [GO:1990086]; lens fiber cell differentiation [GO:0070306]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; neuroblast differentiation [GO:0014016]; neuroblast migration [GO:0097402]; optic vesicle morphogenesis [GO:0003404]; pituitary gland development [GO:0021983]; proximal/distal axis specification [GO:0009946]; regulation of cell cycle phase transition [GO:1901987]; regulation of cell population proliferation [GO:0042127]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of neural retina development [GO:0061074]; regulation of neuroblast proliferation [GO:1902692]; regulation of transcription by RNA polymerase II [GO:0006357]; telencephalon development [GO:0021537]; telencephalon regionalization [GO:0021978]; visual perception [GO:0007601]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor binding [GO:0005102]; transcription corepressor binding [GO:0001222]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor binding [GO:0005102]; transcription corepressor binding [GO:0001222]; apoptotic process involved in development [GO:1902742]; brain development [GO:0007420]; cell proliferation in forebrain [GO:0021846]; epithelial cell maturation [GO:0002070]; eye development [GO:0001654]; forebrain dorsal/ventral pattern formation [GO:0021798]; lens development in camera-type eye [GO:0002088]; lens fiber cell apoptotic process [GO:1990086]; lens fiber cell differentiation [GO:0070306]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; neuroblast differentiation [GO:0014016]; neuroblast migration [GO:0097402]; optic vesicle morphogenesis [GO:0003404]; pituitary gland development [GO:0021983]; proximal/distal axis specification [GO:0009946]; regulation of cell cycle phase transition [GO:1901987]; regulation of cell population proliferation [GO:0042127]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of neural retina development [GO:0061074]; regulation of neuroblast proliferation [GO:1902692]; regulation of transcription by RNA polymerase II [GO:0006357]; telencephalon development [GO:0021537]; telencephalon regionalization [GO:0021978]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q62233, ECO:0000255|PROSITE-ProRule:PRU00108}.
O95347	reviewed	SMC2_HUMAN	Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog)	SMC2 CAPE SMC2L1 PRO0324	Homo sapiens (Human)	1197	FUNCTION: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.		cell division [GO:0051301]; kinetochore organization [GO:0051383]; meiotic chromosome condensation [GO:0010032]; meiotic chromosome segregation [GO:0045132]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	chromatin [GO:0000785]; condensed chromosome [GO:0000793]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; condensed chromosome [GO:0000793]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; single-stranded DNA binding [GO:0003697]; cell division [GO:0051301]; kinetochore organization [GO:0051383]; meiotic chromosome condensation [GO:0010032]; meiotic chromosome segregation [GO:0045132]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
O95352	reviewed	ATG7_HUMAN	Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein)	ATG7 APG7L	Homo sapiens (Human)	703	FUNCTION: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (PubMed:34161705). Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9D906, ECO:0000269|PubMed:11096062, ECO:0000269|PubMed:16303767, ECO:0000269|PubMed:22170151, ECO:0000269|PubMed:34161705}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to hyperoxia [GO:0071455]; cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; defense response to virus [GO:0051607]; late nucleophagy [GO:0044805]; macroautophagy [GO:0016236]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein modification process [GO:0031401]; protein lipidation [GO:0006497]; protein modification by small protein conjugation [GO:0032446]; protein transport [GO:0015031]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]	axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; phagophore assembly site [GO:0000407]; secretory granule lumen [GO:0034774]	Atg12 activating enzyme activity [GO:0019778]; Atg8 activating enzyme activity [GO:0019779]; protein homodimerization activity [GO:0042803]	axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; phagophore assembly site [GO:0000407]; secretory granule lumen [GO:0034774]; Atg12 activating enzyme activity [GO:0019778]; Atg8 activating enzyme activity [GO:0019779]; protein homodimerization activity [GO:0042803]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to hyperoxia [GO:0071455]; cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; defense response to virus [GO:0051607]; late nucleophagy [GO:0044805]; macroautophagy [GO:0016236]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein modification process [GO:0031401]; protein lipidation [GO:0006497]; protein modification by small protein conjugation [GO:0032446]; protein transport [GO:0015031]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
O95359	reviewed	TACC2_HUMAN	Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1)	TACC2	Homo sapiens (Human)	2948	FUNCTION: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}.		cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	nuclear receptor binding [GO:0016922]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; nuclear receptor binding [GO:0016922]; cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10749935}. Nucleus {ECO:0000269|PubMed:10749935, ECO:0000269|PubMed:14767476}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15304323}.
O95361	reviewed	TRI16_HUMAN	Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein)	TRIM16 EBBP	Homo sapiens (Human)	564	FUNCTION: E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}.		positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; response to growth hormone [GO:0060416]; response to organophosphorus [GO:0046683]; response to retinoic acid [GO:0032526]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; PML body [GO:0016605]	DNA binding [GO:0003677]; interleukin-1 binding [GO:0019966]; NACHT domain binding [GO:0032089]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; PML body [GO:0016605]; DNA binding [GO:0003677]; interleukin-1 binding [GO:0019966]; NACHT domain binding [GO:0032089]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; response to growth hormone [GO:0060416]; response to organophosphorus [GO:0046683]; response to retinoic acid [GO:0032526]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27693506}.
O95363	reviewed	SYFM_HUMAN	Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS)	FARS2 FARS1 HSPC320	Homo sapiens (Human)	451	FUNCTION: Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins. {ECO:0000269|PubMed:19549855, ECO:0000269|PubMed:22833457}.		phenylalanyl-tRNA aminoacylation [GO:0006432]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA processing [GO:0008033]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; phenylalanine-tRNA ligase activity [GO:0004826]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; phenylalanine-tRNA ligase activity [GO:0004826]; tRNA binding [GO:0000049]; phenylalanyl-tRNA aminoacylation [GO:0006432]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA processing [GO:0008033]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q6AYQ3}. Mitochondrion {ECO:0000250|UniProtKB:Q6AYQ3}.
O95365	reviewed	ZBT7A_HUMAN	Zinc finger and BTB domain-containing protein 7A (Factor binding IST protein 1) (FBI-1) (Factor that binds to inducer of short transcripts protein 1) (HIV-1 1st-binding protein 1) (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon) (Pokemon 1) (TTF-I-interacting peptide 21) (TIP21) (Zinc finger protein 857A)	ZBTB7A FBI1 LRF ZBTB7 ZNF857A	Homo sapiens (Human)	584	FUNCTION: Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149). {ECO:0000250|UniProtKB:O88939, ECO:0000250|UniProtKB:Q9QZ48, ECO:0000269|PubMed:12004059, ECO:0000269|PubMed:14701838, ECO:0000269|PubMed:17595526, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:24514149, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:26455326, ECO:0000269|PubMed:26816381}.		B cell differentiation [GO:0030183]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; erythrocyte maturation [GO:0043249]; fat cell differentiation [GO:0045444]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein localization to nucleus [GO:0034504]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of glycolytic process [GO:0006110]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription regulatory region DNA binding [GO:2000677]	cytoplasm [GO:0005737]; DNA-dependent protein kinase complex [GO:0070418]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]; transcription corepressor binding [GO:0001222]	cytoplasm [GO:0005737]; DNA-dependent protein kinase complex [GO:0070418]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]; transcription corepressor binding [GO:0001222]; B cell differentiation [GO:0030183]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; erythrocyte maturation [GO:0043249]; fat cell differentiation [GO:0045444]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein localization to nucleus [GO:0034504]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of glycolytic process [GO:0006110]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription regulatory region DNA binding [GO:2000677]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17595526, ECO:0000269|PubMed:24514149}. Note=Recruited to double-strand break sites of damaged DNA. {ECO:0000250|UniProtKB:O88939}.
O95372	reviewed	LYPA2_HUMAN	Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase II) (LPL-II) (LysoPLA II) (Palmitoyl-protein hydrolase) (EC 3.1.2.22)	LYPLA2 APT2	Homo sapiens (Human)	231	FUNCTION: Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951). {ECO:0000269|PubMed:21152083, ECO:0000269|PubMed:25301951, ECO:0000269|PubMed:28826475}.		acylglycerol catabolic process [GO:0046464]; axon guidance [GO:0007411]; fatty acid metabolic process [GO:0006631]; prostaglandin catabolic process [GO:1905344]; protein depalmitoylation [GO:0002084]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi stack [GO:0005795]; nucleoplasm [GO:0005654]	cadherin binding [GO:0045296]; carboxylic ester hydrolase activity [GO:0052689]; lysophospholipase activity [GO:0004622]; palmitoyl-(protein) hydrolase activity [GO:0008474]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi stack [GO:0005795]; nucleoplasm [GO:0005654]; cadherin binding [GO:0045296]; carboxylic ester hydrolase activity [GO:0052689]; lysophospholipase activity [GO:0004622]; palmitoyl-(protein) hydrolase activity [GO:0008474]; acylglycerol catabolic process [GO:0046464]; axon guidance [GO:0007411]; fatty acid metabolic process [GO:0006631]; prostaglandin catabolic process [GO:1905344]; protein depalmitoylation [GO:0002084]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25301951}.
O95373	reviewed	IPO7_HUMAN	Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7)	IPO7 RANBP7	Homo sapiens (Human)	1038	FUNCTION: Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. Promotes odontoblast differentiation via promoting nuclear translocation of DLX3, KLF4, SMAD2, thereby facilitating the transcription of target genes that play a role in odontoblast differentiation (By similarity). Facilitates BMP4-induced translocation of SMAD1 to the nucleus and recruitment to the MSX1 gene promoter, thereby promotes the expression of the odontogenic regulator MSX1 in dental mesenchymal cells (By similarity). Also promotes odontoblast differentiation by facilitating the nuclear translocation of HDAC6 and subsequent repression of RUNX2 expression (By similarity). Inhibits osteoblast differentiation by inhibiting nuclear translocation of RUNX2 and therefore inhibition of RUNX2 target gene transcription (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. {ECO:0000250|UniProtKB:Q9EPL8, ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) Mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. Binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:12853482, ECO:0000269|PubMed:16704975}.		innate immune response [GO:0045087]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of protein localization to nucleus [GO:1900182]; protein import into nucleus [GO:0006606]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]	GTPase regulator activity [GO:0030695]; histone binding [GO:0042393]; SMAD binding [GO:0046332]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; GTPase regulator activity [GO:0030695]; histone binding [GO:0042393]; SMAD binding [GO:0046332]; small GTPase binding [GO:0031267]; innate immune response [GO:0045087]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of protein localization to nucleus [GO:1900182]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9EPL8}. Nucleus {ECO:0000250|UniProtKB:Q9EPL8}. Note=Localizes to the nucleus in the presence of BMP4. {ECO:0000250|UniProtKB:Q9EPL8}.
O95376	reviewed	ARI2_HUMAN	E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein)	ARIH2 ARI2 TRIAD1 HT005	Homo sapiens (Human)	493	FUNCTION: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). {ECO:0000250|UniProtKB:Q9Y4X5, ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:24076655}.		developmental cell growth [GO:0048588]; hematopoietic stem cell proliferation [GO:0071425]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; developmental cell growth [GO:0048588]; hematopoietic stem cell proliferation [GO:0071425]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16118314}. Cytoplasm {ECO:0000269|PubMed:19340006}.
O95377	reviewed	CXB5_HUMAN	Gap junction beta-5 protein (Connexin-31.1) (Cx31.1)	GJB5	Homo sapiens (Human)	273	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.		cell-cell signaling [GO:0007267]; epidermis development [GO:0008544]; epididymis development [GO:1905867]; labyrinthine layer morphogenesis [GO:0060713]; spongiotrophoblast differentiation [GO:0060708]; trophoblast giant cell differentiation [GO:0060707]	connexin complex [GO:0005922]	gap junction channel activity [GO:0005243]	connexin complex [GO:0005922]; gap junction channel activity [GO:0005243]; cell-cell signaling [GO:0007267]; epidermis development [GO:0008544]; epididymis development [GO:1905867]; labyrinthine layer morphogenesis [GO:0060713]; spongiotrophoblast differentiation [GO:0060708]; trophoblast giant cell differentiation [GO:0060707]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
O95379	reviewed	TFIP8_HUMAN	Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1)	TNFAIP8	Homo sapiens (Human)	198	FUNCTION: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. {ECO:0000269|PubMed:10644768, ECO:0000269|PubMed:11346652, ECO:0000269|PubMed:14724590}.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14724590}.
O95382	reviewed	M3K6_HUMAN	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)	MAP3K6 ASK2 MAPKKK6 MEKK6	Homo sapiens (Human)	1288	FUNCTION: Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}.		protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]		ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein serine kinase activity [GO:0106310]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein serine kinase activity [GO:0106310]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	
O95388	reviewed	CCN4_HUMAN	CCN family member 4 (WNT1-inducible-signaling pathway protein 1) (WISP-1) (Wnt-1-induced secreted protein)	CCN4 WISP1	Homo sapiens (Human)	367	FUNCTION: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. {ECO:0000269|PubMed:10716946, ECO:0000269|PubMed:11782444}.		bone development [GO:0060348]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; glucose homeostasis [GO:0042593]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of fat cell differentiation [GO:0045599]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; positive regulation of inflammatory response [GO:0050729]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of wound healing [GO:0090303]; regulation of cytokine production [GO:0001817]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	heparin binding [GO:0008201]; integrin binding [GO:0005178]	cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; bone development [GO:0060348]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; glucose homeostasis [GO:0042593]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of fat cell differentiation [GO:0045599]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; positive regulation of inflammatory response [GO:0050729]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of wound healing [GO:0090303]; regulation of cytokine production [GO:0001817]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Secreted.
O95389	reviewed	CCN6_HUMAN	Cellular communication network factor 6 (CCN family member 6) (WNT1-inducible-signaling pathway protein 3) (WISP-3)	CCN6 WISP3 UNQ462/PRO790/PRO956	Homo sapiens (Human)	354	FUNCTION: Plays a role in mitochondrial electron transport and mitochondrial respiration (PubMed:27252383). Through its regulation of the mitochondrial function may play a role in normal postnatal skeletal growth and cartilage homeostasis (PubMed:27252383, PubMed:10471507). {ECO:0000269|PubMed:10471507, ECO:0000269|PubMed:27252383}.		cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; signal transduction [GO:0007165]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]	growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27252383}. Mitochondrion {ECO:0000269|PubMed:27252383}. Note=Associated with membranes. {ECO:0000269|PubMed:27252383}.
O95390	reviewed	GDF11_HUMAN	Growth/differentiation factor 11 (GDF-11) (Bone morphogenetic protein 11) (BMP-11)	GDF11 BMP11	Homo sapiens (Human)	407	FUNCTION: Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and orofacial development (PubMed:31215115). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634). {ECO:0000250|UniProtKB:Q9Z1W4, ECO:0000269|PubMed:28257634, ECO:0000269|PubMed:31215115}.		amacrine cell differentiation [GO:0035881]; camera-type eye morphogenesis [GO:0048593]; cell population proliferation [GO:0008283]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of amacrine cell differentiation [GO:1902870]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395]; spinal cord anterior/posterior patterning [GO:0021512]; type B pancreatic cell maturation [GO:0072560]; ureteric bud development [GO:0001657]	extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]	extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; amacrine cell differentiation [GO:0035881]; camera-type eye morphogenesis [GO:0048593]; cell population proliferation [GO:0008283]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of amacrine cell differentiation [GO:1902870]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395]; spinal cord anterior/posterior patterning [GO:0021512]; type B pancreatic cell maturation [GO:0072560]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O95391	reviewed	SLU7_HUMAN	Pre-mRNA-splicing factor SLU7 (hSlu7)	SLU7	Homo sapiens (Human)	586	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154). Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:10647016, ECO:0000269|PubMed:12764196, ECO:0000269|PubMed:15181151, ECO:0000269|PubMed:15728250, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}.		alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to heat [GO:0034605]; intracellular protein transport [GO:0006886]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; spliceosomal complex [GO:0005681]	pre-mRNA 3'-splice site binding [GO:0030628]; second spliceosomal transesterification activity [GO:0000386]; zinc ion binding [GO:0008270]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; spliceosomal complex [GO:0005681]; pre-mRNA 3'-splice site binding [GO:0030628]; second spliceosomal transesterification activity [GO:0000386]; zinc ion binding [GO:0008270]; alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to heat [GO:0034605]; intracellular protein transport [GO:0006886]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:15728250, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}. Nucleus speckle {ECO:0000269|PubMed:15181151}. Cytoplasm {ECO:0000269|PubMed:15728250}. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. {ECO:0000269|PubMed:15728250}.
O95393	reviewed	BMP10_HUMAN	Bone morphogenetic protein 10 (BMP-10)	BMP10	Homo sapiens (Human)	424	FUNCTION: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. {ECO:0000269|PubMed:16049014, ECO:0000269|PubMed:17068149, ECO:0000269|PubMed:20608934}.		activin receptor signaling pathway [GO:0032924]; adult heart development [GO:0007512]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; BMP signaling pathway [GO:0030509]; cardiac muscle cell proliferation [GO:0060038]; cell adhesion [GO:0007155]; heart trabecula formation [GO:0060347]; kidney development [GO:0001822]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell migration [GO:0010596]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle hypertrophy in response to stress [GO:1903242]; sarcomere organization [GO:0045214]; ventricular cardiac muscle cell development [GO:0055015]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Z disc [GO:0030018]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; receptor serine/threonine kinase binding [GO:0033612]; telethonin binding [GO:0031433]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Z disc [GO:0030018]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; receptor serine/threonine kinase binding [GO:0033612]; telethonin binding [GO:0031433]; activin receptor signaling pathway [GO:0032924]; adult heart development [GO:0007512]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; BMP signaling pathway [GO:0030509]; cardiac muscle cell proliferation [GO:0060038]; cell adhesion [GO:0007155]; heart trabecula formation [GO:0060347]; kidney development [GO:0001822]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell migration [GO:0010596]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle hypertrophy in response to stress [GO:1903242]; sarcomere organization [GO:0045214]; ventricular cardiac muscle cell development [GO:0055015]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
O95394	reviewed	AGM1_HUMAN	Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3)	PGM3 AGM1	Homo sapiens (Human)	542	FUNCTION: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. {ECO:0000303|PubMed:24589341, ECO:0000303|PubMed:24698316, ECO:0000303|PubMed:24931394}.		carbohydrate metabolic process [GO:0005975]; glucosamine metabolic process [GO:0006041]; hemopoiesis [GO:0030097]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; spermatogenesis [GO:0007283]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	cytosol [GO:0005829]	magnesium ion binding [GO:0000287]; phosphoacetylglucosamine mutase activity [GO:0004610]	cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; phosphoacetylglucosamine mutase activity [GO:0004610]; carbohydrate metabolic process [GO:0005975]; glucosamine metabolic process [GO:0006041]; hemopoiesis [GO:0030097]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; spermatogenesis [GO:0007283]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	
O95395	reviewed	GCNT3_HUMAN	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (hC2GnT-M) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase) (C2/4GnT)	GCNT3	Homo sapiens (Human)	438	FUNCTION: Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. {ECO:0000269|PubMed:9915862}.		carbohydrate metabolic process [GO:0005975]; intestinal absorption [GO:0050892]; kidney morphogenesis [GO:0060993]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; tissue morphogenesis [GO:0048729]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0106325]; acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0106326]; acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0106325]; acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0106326]; acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]; carbohydrate metabolic process [GO:0005975]; intestinal absorption [GO:0050892]; kidney morphogenesis [GO:0060993]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; tissue morphogenesis [GO:0048729]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
O95396	reviewed	MOCS3_HUMAN	Adenylyltransferase and sulfurtransferase MOCS3 (Molybdenum cofactor synthesis protein 3) (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase) [Includes: Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (Adenylyltransferase MOCS3) (Sulfur carrier protein MOCS2A adenylyltransferase); Molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (Sulfur carrier protein MOCS2A sulfurtransferase) (Sulfurtransferase MOCS3)]	MOCS3 UBA4	Homo sapiens (Human)	460	FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 acting as a sulfur donor for thiocarboxylation reactions. {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332, ECO:0000269|PubMed:19017811, ECO:0000269|PubMed:30817134}.		Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor metabolic process [GO:0043545]; protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble position uridine thiolation [GO:0002143]; tRNA wobble uridine modification [GO:0002098]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; molybdopterin-synthase adenylyltransferase activity [GO:0061605]; molybdopterin-synthase sulfurtransferase activity [GO:0061604]; nucleotidyltransferase activity [GO:0016779]; sulfurtransferase activity [GO:0016783]; thiosulfate sulfurtransferase activity [GO:0004792]; URM1 activating enzyme activity [GO:0042292]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; molybdopterin-synthase adenylyltransferase activity [GO:0061605]; molybdopterin-synthase sulfurtransferase activity [GO:0061604]; nucleotidyltransferase activity [GO:0016779]; sulfurtransferase activity [GO:0016783]; thiosulfate sulfurtransferase activity [GO:0004792]; URM1 activating enzyme activity [GO:0042292]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor metabolic process [GO:0043545]; protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble position uridine thiolation [GO:0002143]; tRNA wobble uridine modification [GO:0002098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332, ECO:0000269|PubMed:23593335}.
O95398	reviewed	RPGF3_HUMAN	Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI)	RAPGEF3 CGEF1 EPAC EPAC1	Homo sapiens (Human)	923	FUNCTION: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:9853756}.		adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; associative learning [GO:0008306]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; establishment of endothelial barrier [GO:0061028]; negative regulation of syncytium formation by plasma membrane fusion [GO:0034242]; positive regulation of angiogenesis [GO:0045766]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of syncytium formation by plasma membrane fusion [GO:0060143]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiogenesis [GO:0045765]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; signal transduction [GO:0007165]	endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	cAMP binding [GO:0030552]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein domain specific binding [GO:0019904]	endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; cAMP binding [GO:0030552]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein domain specific binding [GO:0019904]; adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; associative learning [GO:0008306]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; establishment of endothelial barrier [GO:0061028]; negative regulation of syncytium formation by plasma membrane fusion [GO:0034242]; positive regulation of angiogenesis [GO:0045766]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of syncytium formation by plasma membrane fusion [GO:0060143]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiogenesis [GO:0045765]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:10777494}.
O95399	reviewed	UTS2_HUMAN	Urotensin-2 (Urotensin II) (U-II) (UII)	UTS2 UNQ525/PRO1068	Homo sapiens (Human)	124	FUNCTION: Highly potent vasoconstrictor.		blood vessel diameter maintenance [GO:0097746]; chemical synaptic transmission [GO:0007268]; muscle contraction [GO:0006936]; regulation of blood pressure [GO:0008217]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; synapse [GO:0045202]	hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; synapse [GO:0045202]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; blood vessel diameter maintenance [GO:0097746]; chemical synaptic transmission [GO:0007268]; muscle contraction [GO:0006936]; regulation of blood pressure [GO:0008217]	SUBCELLULAR LOCATION: Secreted.
O95400	reviewed	CD2B2_HUMAN	CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K)	CD2BP2 KIAA1178	Homo sapiens (Human)	341	FUNCTION: Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}.		spliceosomal tri-snRNP complex assembly [GO:0000244]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U5 snRNP [GO:0005682]	ribonucleoprotein complex binding [GO:0043021]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U5 snRNP [GO:0005682]; ribonucleoprotein complex binding [GO:0043021]; spliceosomal tri-snRNP complex assembly [GO:0000244]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly nuclear.
O95402	reviewed	MED26_HUMAN	Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70)	MED26 ARC70 CRSP7	Homo sapiens (Human)	600	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.		positive regulation of gene expression [GO:0010628]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O95405	reviewed	ZFYV9_HUMAN	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)	ZFYVE9 MADHIP SARA SMADIP	Homo sapiens (Human)	1425	FUNCTION: Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. {ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:9865696}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	endocytosis [GO:0006897]; endosomal transport [GO:0016197]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; protein-containing complex [GO:0032991]	1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; protein-containing complex [GO:0032991]; 1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm. Early endosome membrane.
O95406	reviewed	CNIH1_HUMAN	Protein cornichon homolog 1 (CNIH-1) (Cornichon family AMPA receptor auxiliary protein 1) (Protein cornichon homolog) (T-cell growth-associated molecule 77) (TGAM77)	CNIH1 CNIH CNIL UNQ155/PRO181	Homo sapiens (Human)	144	FUNCTION: Involved in the selective transport and maturation of TGF-alpha family proteins. {ECO:0000269|PubMed:17607000}.		immune response [GO:0006955]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]		endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; immune response [GO:0006955]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17607000}; Multi-pass membrane protein {ECO:0000269|PubMed:17607000}. Golgi apparatus membrane {ECO:0000269|PubMed:17607000}. Note=Located primarily in the ER; may cycle between the ER and the Golgi apparatus.
O95407	reviewed	TNF6B_HUMAN	Tumor necrosis factor receptor superfamily member 6B (Decoy receptor 3) (DcR3) (Decoy receptor for Fas ligand) (M68)	TNFRSF6B DCR3 TR6 UNQ186/PRO212	Homo sapiens (Human)	300	FUNCTION: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. {ECO:0000269|PubMed:21300286}.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	signaling receptor activity [GO:0038023]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; signaling receptor activity [GO:0038023]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]	SUBCELLULAR LOCATION: Secreted.
O95409	reviewed	ZIC2_HUMAN	Zinc finger protein ZIC 2 (Zinc finger protein of the cerebellum 2)	ZIC2	Homo sapiens (Human)	532	FUNCTION: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.		brain development [GO:0007420]; cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; brain development [GO:0007420]; cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity). {ECO:0000250}.
O95415	reviewed	BRI3_HUMAN	Membrane protein BRI3 (Brain protein I3) (pRGR2)	BRI3	Homo sapiens (Human)	125	FUNCTION: Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055). {ECO:0000269|PubMed:14592447, ECO:0000269|PubMed:20538055}.			azurophil granule membrane [GO:0035577]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	azurophil granule membrane [GO:0035577]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000305|PubMed:14592447}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:30983867}. Note=Co-localizes with MGAT1 and IFITM3 at the perinuclear region. {ECO:0000269|PubMed:30983867}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:30983867}. Nucleus {ECO:0000269|PubMed:30983867}. Note=Diffuse localization in the cytoplasm and nucleus. {ECO:0000269|PubMed:30983867}.
O95416	reviewed	SOX14_HUMAN	Transcription factor SOX-14 (Protein SOX-28)	SOX14 SOX28	Homo sapiens (Human)	240	FUNCTION: Acts as a negative regulator of transcription. {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; entrainment of circadian clock [GO:0009649]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron migration [GO:2001222]; visual perception [GO:0007601]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; entrainment of circadian clock [GO:0009649]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron migration [GO:2001222]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
O95425	reviewed	SVIL_HUMAN	Supervillin (Archvillin) (p205/p250)	SVIL	Homo sapiens (Human)	2214	FUNCTION: [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}.		actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; positive regulation of cytokinesis [GO:0032467]; skeletal muscle tissue development [GO:0007519]	actin cytoskeleton [GO:0015629]; cell projection [GO:0042995]; cleavage furrow [GO:0032154]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; microtubule minus-end [GO:0036449]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102]	actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	actin cytoskeleton [GO:0015629]; cell projection [GO:0042995]; cleavage furrow [GO:0032154]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; microtubule minus-end [GO:0036449]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102]; actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; positive regulation of cytokinesis [GO:0032467]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Midbody {ECO:0000250|UniProtKB:O46385}. Cleavage furrow {ECO:0000250|UniProtKB:O46385}. Note=Tightly associated with both actin filaments and plasma membranes.
O95427	reviewed	PIGN_HUMAN	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (MCD4 homolog) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N)	PIGN MCD4	Homo sapiens (Human)	931	FUNCTION: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation. {ECO:0000250, ECO:0000269|PubMed:23446422}.		preassembly of GPI anchor in ER membrane [GO:0016254]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	mannose-ethanolamine phosphotransferase activity [GO:0051377]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; mannose-ethanolamine phosphotransferase activity [GO:0051377]; preassembly of GPI anchor in ER membrane [GO:0016254]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
O95428	reviewed	PPN_HUMAN	Papilin	PAPLN UNQ2420/PRO4977	Homo sapiens (Human)	1278			extracellular matrix organization [GO:0030198]	extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O95429	reviewed	BAG4_HUMAN	BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains)	BAG4 SODD	Homo sapiens (Human)	457	FUNCTION: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}.		cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mRNA modification [GO:0090367]; negative regulation of protein targeting to mitochondrion [GO:1903215]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell adhesion [GO:0045785]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of stress fiber assembly [GO:0051496]; protein folding [GO:0006457]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; ruffle assembly [GO:0097178]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	adenyl-nucleotide exchange factor activity [GO:0000774]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; adenyl-nucleotide exchange factor activity [GO:0000774]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mRNA modification [GO:0090367]; negative regulation of protein targeting to mitochondrion [GO:1903215]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell adhesion [GO:0045785]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of stress fiber assembly [GO:0051496]; protein folding [GO:0006457]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; ruffle assembly [GO:0097178]	SUBCELLULAR LOCATION: Cytoplasm.
O95433	reviewed	AHSA1_HUMAN	Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1) (p38)	AHSA1 C14orf3 HSPC322	Homo sapiens (Human)	338	FUNCTION: Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). {ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155}.		positive regulation of ATP-dependent activity [GO:0032781]; protein folding [GO:0006457]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]	ATPase activator activity [GO:0001671]; cadherin binding [GO:0045296]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; ATPase activator activity [GO:0001671]; cadherin binding [GO:0045296]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087]; positive regulation of ATP-dependent activity [GO:0032781]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11554768}. Endoplasmic reticulum {ECO:0000269|PubMed:11554768}. Note=May transiently interact with the endoplasmic reticulum.
O95436	reviewed	NPT2B_HUMAN	Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)	SLC34A2	Homo sapiens (Human)	690	FUNCTION: Involved in actively transporting phosphate into cells via Na(+) cotransport. {ECO:0000269|PubMed:10329428}.		in utero embryonic development [GO:0001701]; intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transport [GO:0006817]; protein metabolic process [GO:0019538]; response to estrogen [GO:0043627]; sodium-dependent phosphate transport [GO:0044341]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	phosphate ion binding [GO:0042301]; sodium ion binding [GO:0031402]; sodium:phosphate symporter activity [GO:0005436]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; phosphate ion binding [GO:0042301]; sodium ion binding [GO:0031402]; sodium:phosphate symporter activity [GO:0005436]; in utero embryonic development [GO:0001701]; intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transport [GO:0006817]; protein metabolic process [GO:0019538]; response to estrogen [GO:0043627]; sodium-dependent phosphate transport [GO:0044341]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9DBP0}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of enterocytes. {ECO:0000250|UniProtKB:Q9DBP0}.
O95445	reviewed	APOM_HUMAN	Apolipoprotein M (Apo-M) (ApoM) (Protein G3a)	APOM G3A NG20 HSPC336	Homo sapiens (Human)	188	FUNCTION: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid. {ECO:0000269|PubMed:17525477, ECO:0000269|PubMed:19733574}.		cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; lipoprotein metabolic process [GO:0042157]; negative regulation of plasma lipoprotein oxidation [GO:0034445]; reverse cholesterol transport [GO:0043691]	discoidal high-density lipoprotein particle [GO:0034365]; extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361]	antioxidant activity [GO:0016209]; lipid transporter activity [GO:0005319]; phospholipid binding [GO:0005543]	discoidal high-density lipoprotein particle [GO:0034365]; extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361]; antioxidant activity [GO:0016209]; lipid transporter activity [GO:0005319]; phospholipid binding [GO:0005543]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; lipoprotein metabolic process [GO:0042157]; negative regulation of plasma lipoprotein oxidation [GO:0034445]; reverse cholesterol transport [GO:0043691]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17525477, ECO:0000269|PubMed:18279674, ECO:0000269|PubMed:18460466}. Note=Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL).
O95447	reviewed	LCA5L_HUMAN	Lebercilin-like protein (Leber congenital amaurosis 5-like protein)	LCA5L C21orf13	Homo sapiens (Human)	670			intraciliary transport [GO:0042073]	axoneme [GO:0005930]		axoneme [GO:0005930]; intraciliary transport [GO:0042073]	
O95450	reviewed	ATS2_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI)	ADAMTS2 PCINP PCPNI	Homo sapiens (Human)	1211	FUNCTION: Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (PubMed:31152061). {ECO:0000250|UniProtKB:P79331, ECO:0000269|PubMed:31152061}.	MISCELLANEOUS: [Isoform SpNPI]: Has no significant N-procollagen peptidase activity. {ECO:0000305}.	collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; lung development [GO:0030324]; protein processing [GO:0016485]; skin development [GO:0043588]; spermatogenesis [GO:0007283]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; lung development [GO:0030324]; protein processing [GO:0016485]; skin development [GO:0043588]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
O95452	reviewed	CXB6_HUMAN	Gap junction beta-6 protein (Connexin-30) (Cx30)	GJB6	Homo sapiens (Human)	261	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.		cell-cell signaling [GO:0007267]; cellular response to glucose stimulus [GO:0071333]; ear morphogenesis [GO:0042471]; gap junction assembly [GO:0016264]; gap junction-mediated intercellular transport [GO:1990349]; inner ear development [GO:0048839]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of cell population proliferation [GO:0008285]; response to electrical stimulus [GO:0051602]; response to lipopolysaccharide [GO:0032496]; sensory perception of sound [GO:0007605]; sinoatrial node development [GO:0003163]; transmembrane transport [GO:0055085]	actin filament [GO:0005884]; apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; connexin complex [GO:0005922]; gap junction [GO:0005921]	actin filament binding [GO:0051015]; beta-tubulin binding [GO:0048487]; gap junction channel activity [GO:0005243]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763]; microtubule binding [GO:0008017]	actin filament [GO:0005884]; apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; connexin complex [GO:0005922]; gap junction [GO:0005921]; actin filament binding [GO:0051015]; beta-tubulin binding [GO:0048487]; gap junction channel activity [GO:0005243]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763]; microtubule binding [GO:0008017]; cell-cell signaling [GO:0007267]; cellular response to glucose stimulus [GO:0071333]; ear morphogenesis [GO:0042471]; gap junction assembly [GO:0016264]; gap junction-mediated intercellular transport [GO:1990349]; inner ear development [GO:0048839]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of cell population proliferation [GO:0008285]; response to electrical stimulus [GO:0051602]; response to lipopolysaccharide [GO:0032496]; sensory perception of sound [GO:0007605]; sinoatrial node development [GO:0003163]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
O95453	reviewed	PARN_HUMAN	Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease)	PARN DAN	Homo sapiens (Human)	639	FUNCTION: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:25049417, PubMed:22442037). {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:9736620}.	MISCELLANEOUS: [Isoform 2]: Non canonical splice junctions. {ECO:0000305}.	box H/ACA RNA 3'-end processing [GO:0000495]; female gamete generation [GO:0007292]; miRNA catabolic process [GO:0010587]; ncRNA deadenylation [GO:0110008]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; RNA modification [GO:0009451]; telomerase RNA stabilization [GO:0090669]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]	cation binding [GO:0043169]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; nuclease activity [GO:0004518]; poly(A)-specific ribonuclease activity [GO:0004535]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; cation binding [GO:0043169]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; nuclease activity [GO:0004518]; poly(A)-specific ribonuclease activity [GO:0004535]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; box H/ACA RNA 3'-end processing [GO:0000495]; female gamete generation [GO:0007292]; miRNA catabolic process [GO:0010587]; ncRNA deadenylation [GO:0110008]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; RNA modification [GO:0009451]; telomerase RNA stabilization [GO:0090669]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9736620}. Cytoplasm {ECO:0000269|PubMed:9736620}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:22442037}. Note=Some nuclear fraction is nucleolar.
O95456	reviewed	PSMG1_HUMAN	Proteasome assembly chaperone 1 (PAC-1) (Chromosome 21 leucine-rich protein) (C21-LRP) (Down syndrome critical region protein 2)	PSMG1 C21LRP DSCR2 PAC1	Homo sapiens (Human)	288	FUNCTION: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}.		cerebellar granule cell precursor proliferation [GO:0021930]; chaperone-mediated protein complex assembly [GO:0051131]; proteasome core complex assembly [GO:0080129]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]	molecular adaptor activity [GO:0060090]; proteasome binding [GO:0070628]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; molecular adaptor activity [GO:0060090]; proteasome binding [GO:0070628]; cerebellar granule cell precursor proliferation [GO:0021930]; chaperone-mediated protein complex assembly [GO:0051131]; proteasome core complex assembly [GO:0080129]	SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum.
O95460	reviewed	MATN4_HUMAN	Matrilin-4	MATN4	Homo sapiens (Human)	622	FUNCTION: Major component of the extracellular matrix of cartilage.		extracellular matrix organization [GO:0030198]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; matrilin complex [GO:0120216]	calcium ion binding [GO:0005509]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; matrilin complex [GO:0120216]; calcium ion binding [GO:0005509]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted.
O95461	reviewed	LARG1_HUMAN	Xylosyl- and glucuronyltransferase LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A) (Glycosyltransferase-like protein) (LARGE xylosyl- and glucuronyltransferase 1) [Includes: Alpha-1,3-xylosyltransferase LARGE1 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE1 (EC 2.4.1.-)]	LARGE1 KIAA0609 LARGE	Homo sapiens (Human)	756	FUNCTION: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity (PubMed:22223806, PubMed:15752776, PubMed:15661757, PubMed:25279699, PubMed:25279697, PubMed:23125099, PubMed:21987822). Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:22223806, PubMed:25279699, PubMed:25279697, PubMed:25138275, PubMed:32975514, PubMed:23125099). Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer (PubMed:21987822). Plays a key role in skeletal muscle function and regeneration (By similarity). {ECO:0000250|UniProtKB:Q9Z1M7, ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15752776, ECO:0000269|PubMed:21987822, ECO:0000269|PubMed:22223806, ECO:0000269|PubMed:23125099, ECO:0000269|PubMed:25138275, ECO:0000269|PubMed:25279697, ECO:0000269|PubMed:25279699, ECO:0000269|PubMed:32975514}.		acetylcholine receptor signaling pathway [GO:0095500]; astrocyte differentiation [GO:0048708]; basement membrane organization [GO:0071711]; behavioral fear response [GO:0001662]; blood vessel development [GO:0001568]; bone development [GO:0060348]; cardiac muscle cell development [GO:0055013]; connective tissue development [GO:0061448]; cytoskeleton organization [GO:0007010]; dentate gyrus development [GO:0021542]; determination of adult lifespan [GO:0008340]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; localization of cell [GO:0051674]; long-term synaptic potentiation [GO:0060291]; macrophage differentiation [GO:0030225]; memory [GO:0007613]; multicellular organism growth [GO:0035264]; multicellular organism reproduction [GO:0032504]; muscle cell cellular homeostasis [GO:0046716]; myelination [GO:0042552]; N-acetylglucosamine metabolic process [GO:0006044]; nerve development [GO:0021675]; neuromuscular process controlling posture [GO:0050884]; neuromuscular synaptic transmission [GO:0007274]; neuron migration [GO:0001764]; plasma membrane organization [GO:0007009]; post-embryonic hindlimb morphogenesis [GO:0035129]; post-translational protein modification [GO:0043687]; potassium ion transmembrane transport [GO:0071805]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; protein glycosylation [GO:0006486]; protein localization to plasma membrane [GO:0072659]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]; protein targeting to membrane [GO:0006612]; protein-containing complex assembly [GO:0065003]; reactive gliosis [GO:0150103]; response to light stimulus [GO:0009416]; response to mechanical stimulus [GO:0009612]; retina layer formation [GO:0010842]; retina vasculature development in camera-type eye [GO:0061298]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle organ development [GO:0060538]; skeletal muscle tissue regeneration [GO:0043403]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; synaptic assembly at neuromuscular junction [GO:0051124]; walking behavior [GO:0090659]; water transport [GO:0006833]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyltransferase activity [GO:0015020]; glycosyltransferase activity [GO:0016757]; hexosyltransferase activity [GO:0016758]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyltransferase activity [GO:0042285]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyltransferase activity [GO:0015020]; glycosyltransferase activity [GO:0016757]; hexosyltransferase activity [GO:0016758]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyltransferase activity [GO:0042285]; acetylcholine receptor signaling pathway [GO:0095500]; astrocyte differentiation [GO:0048708]; basement membrane organization [GO:0071711]; behavioral fear response [GO:0001662]; blood vessel development [GO:0001568]; bone development [GO:0060348]; cardiac muscle cell development [GO:0055013]; connective tissue development [GO:0061448]; cytoskeleton organization [GO:0007010]; dentate gyrus development [GO:0021542]; determination of adult lifespan [GO:0008340]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; localization of cell [GO:0051674]; long-term synaptic potentiation [GO:0060291]; macrophage differentiation [GO:0030225]; memory [GO:0007613]; multicellular organism growth [GO:0035264]; multicellular organism reproduction [GO:0032504]; muscle cell cellular homeostasis [GO:0046716]; myelination [GO:0042552]; N-acetylglucosamine metabolic process [GO:0006044]; nerve development [GO:0021675]; neuromuscular process controlling posture [GO:0050884]; neuromuscular synaptic transmission [GO:0007274]; neuron migration [GO:0001764]; plasma membrane organization [GO:0007009]; post-embryonic hindlimb morphogenesis [GO:0035129]; post-translational protein modification [GO:0043687]; potassium ion transmembrane transport [GO:0071805]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; protein glycosylation [GO:0006486]; protein localization to plasma membrane [GO:0072659]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]; protein targeting to membrane [GO:0006612]; protein-containing complex assembly [GO:0065003]; reactive gliosis [GO:0150103]; response to light stimulus [GO:0009416]; response to mechanical stimulus [GO:0009612]; retina layer formation [GO:0010842]; retina vasculature development in camera-type eye [GO:0061298]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle organ development [GO:0060538]; skeletal muscle tissue regeneration [GO:0043403]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; synaptic assembly at neuromuscular junction [GO:0051124]; walking behavior [GO:0090659]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15958417, ECO:0000269|PubMed:25279699}; Single-pass type II membrane protein {ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15958417}.
O95466	reviewed	FMNL1_HUMAN	Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin)	FMNL1 C17orf1 C17orf1B FMNL FRL1	Homo sapiens (Human)	1100	FUNCTION: May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.	MISCELLANEOUS: [Isoform 3]: Due to intron retention. Constitutively activated form, probably due to alterations in the DAD domain. {ECO:0000305}.	actin filament severing [GO:0051014]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; regulation of cell shape [GO:0008360]	bleb [GO:0032059]; cell cortex [GO:0005938]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; GTPase activating protein binding [GO:0032794]; small GTPase binding [GO:0031267]	bleb [GO:0032059]; cell cortex [GO:0005938]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; GTPase activating protein binding [GO:0032794]; small GTPase binding [GO:0031267]; actin filament severing [GO:0051014]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19815554}; Lipid-anchor {ECO:0000269|PubMed:19815554}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions.
O95467	reviewed	GNAS3_HUMAN	Neuroendocrine secretory protein 55 (NESP55) [Cleaved into: LHAL tetrapeptide; GPIPIRRH peptide]	GNAS GNAS1	Homo sapiens (Human)	245		MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the ALEX protein from an overlapping reading frame. {ECO:0000305}.; MISCELLANEOUS: The GNAS locus is imprinted in a complex manner, giving rise to distinct paternally, maternally and biallelically expressed proteins. The XLas isoforms are paternally derived, the Gnas isoforms are biallelically derived and the Nesp55 isoforms are maternally derived.; MISCELLANEOUS: [Isoform Nesp55]: Shares no sequence similarity with other isoforms due to a novel first exon containing the entire reading frame spliced to shared exon 2 so that exons 2-13 make up the 3'-UTR.	female pregnancy [GO:0007565]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of cold-induced thermogenesis [GO:0120162]; protein secretion [GO:0009306]; response to parathyroid hormone [GO:0071107]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle [GO:0030133]		cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle [GO:0030133]; female pregnancy [GO:0007565]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of cold-induced thermogenesis [GO:0120162]; protein secretion [GO:0009306]; response to parathyroid hormone [GO:0071107]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Secreted {ECO:0000250}. Note=Neuroendocrine secretory granules. {ECO:0000250}.
O95470	reviewed	SGPL1_HUMAN	Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)	SGPL1 KIAA1252	Homo sapiens (Human)	568	FUNCTION: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). {ECO:0000250|UniProtKB:Q8R0X7, ECO:0000250|UniProtKB:Q9V7Y2, ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814, ECO:0000269|PubMed:28165339}.		androgen metabolic process [GO:0008209]; apoptotic signaling pathway [GO:0097190]; ceramide metabolic process [GO:0006672]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; fatty acid metabolic process [GO:0006631]; fibroblast migration [GO:0010761]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; regulation of multicellular organism growth [GO:0040014]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid catabolic process [GO:0030149]; vasculogenesis [GO:0001570]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	pyridoxal phosphate binding [GO:0030170]; sphinganine-1-phosphate aldolase activity [GO:0008117]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; pyridoxal phosphate binding [GO:0030170]; sphinganine-1-phosphate aldolase activity [GO:0008117]; androgen metabolic process [GO:0008209]; apoptotic signaling pathway [GO:0097190]; ceramide metabolic process [GO:0006672]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; fatty acid metabolic process [GO:0006631]; fibroblast migration [GO:0010761]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; regulation of multicellular organism growth [GO:0040014]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid catabolic process [GO:0030149]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14570870}; Single-pass type III membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R0X7}.
O95471	reviewed	CLD7_HUMAN	Claudin-7 (CLDN-7)	CLDN7 CEPTRL2 CPETRL2	Homo sapiens (Human)	211	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of protein-containing complex assembly [GO:0031333]; positive regulation of cell motility [GO:2000147]; positive regulation of cell population proliferation [GO:0008284]; response to ethanol [GO:0045471]	apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; structural molecule activity [GO:0005198]	apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of protein-containing complex assembly [GO:0031333]; positive regulation of cell motility [GO:2000147]; positive regulation of cell population proliferation [GO:0008284]; response to ethanol [GO:0045471]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12673207, ECO:0000269|PubMed:14502431, ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:16054130}. Cell junction, tight junction {ECO:0000269|PubMed:16054130}. Note=Co-localizes with EPCAM at the basolateral cell membrane and tight junction. {ECO:0000269|PubMed:16054130}.
O95475	reviewed	SIX6_HUMAN	Homeobox protein SIX6 (Homeodomain protein OPTX2) (Optic homeobox 2) (Sine oculis homeobox homolog 6)	SIX6 OPTX2 SIX9	Homo sapiens (Human)	246	FUNCTION: May be involved in eye development.		animal organ morphogenesis [GO:0009887]; eye development [GO:0001654]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ morphogenesis [GO:0009887]; eye development [GO:0001654]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
O95476	reviewed	CNEP1_HUMAN	CTD nuclear envelope phosphatase 1 (EC 3.1.3.16) (Serine/threonine-protein phosphatase dullard)	CTDNEP1 DULLARD	Homo sapiens (Human)	244	FUNCTION: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. {ECO:0000269|PubMed:17420445, ECO:0000269|PubMed:22134922}.		canonical Wnt signaling pathway [GO:0060070]; gamete generation [GO:0007276]; mesoderm development [GO:0007498]; mitotic nuclear membrane disassembly [GO:0007077]; nuclear envelope organization [GO:0006998]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein dephosphorylation [GO:0006470]; protein localization to nucleus [GO:0034504]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; Nem1-Spo7 phosphatase complex [GO:0071595]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]	myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; Nem1-Spo7 phosphatase complex [GO:0071595]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; canonical Wnt signaling pathway [GO:0060070]; gamete generation [GO:0007276]; mesoderm development [GO:0007498]; mitotic nuclear membrane disassembly [GO:0007077]; nuclear envelope organization [GO:0006998]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein dephosphorylation [GO:0006470]; protein localization to nucleus [GO:0034504]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
O95477	reviewed	ABCA1_HUMAN	Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein)	ABCA1 ABC1 CERP	Homo sapiens (Human)	2261	FUNCTION: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981, PubMed:35974019). Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981, PubMed:35974019). Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain (PubMed:35974019). {ECO:0000269|PubMed:10533863, ECO:0000269|PubMed:14754908, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:35974019}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cholesterol [GO:0071397]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to retinoic acid [GO:0071300]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; endosomal transport [GO:0016197]; export across plasma membrane [GO:0140115]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lysosome organization [GO:0007040]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; platelet dense granule organization [GO:0060155]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of high-density lipoprotein particle assembly [GO:0090107]; response to laminar fluid shear stress [GO:0034616]; response to nutrient [GO:0007584]; reverse cholesterol transport [GO:0043691]; signal release [GO:0023061]	basolateral plasma membrane [GO:0016323]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	ABC-type transporter activity [GO:0140359]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein A-I receptor activity [GO:0034188]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; high-density lipoprotein particle binding [GO:0008035]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transporter activity [GO:0005548]; protein transmembrane transporter activity [GO:0008320]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; sphingolipid floppase activity [GO:0046623]; syntaxin binding [GO:0019905]	basolateral plasma membrane [GO:0016323]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; ABC-type transporter activity [GO:0140359]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein A-I receptor activity [GO:0034188]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; high-density lipoprotein particle binding [GO:0008035]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transporter activity [GO:0005548]; protein transmembrane transporter activity [GO:0008320]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; sphingolipid floppase activity [GO:0046623]; syntaxin binding [GO:0019905]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cholesterol [GO:0071397]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to retinoic acid [GO:0071300]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; endosomal transport [GO:0016197]; export across plasma membrane [GO:0140115]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lysosome organization [GO:0007040]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; platelet dense granule organization [GO:0060155]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of high-density lipoprotein particle assembly [GO:0090107]; response to laminar fluid shear stress [GO:0034616]; response to nutrient [GO:0007584]; reverse cholesterol transport [GO:0043691]; signal release [GO:0023061]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19258317, ECO:0000269|PubMed:19556522, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:35974019}; Multi-pass membrane protein {ECO:0000255}. Endosome {ECO:0000269|PubMed:24097981}.
O95479	reviewed	G6PE_HUMAN	GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) (GDH) (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)]	H6PD GDH	Homo sapiens (Human)	791	FUNCTION: Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (By similarity). Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway (PubMed:12858176, PubMed:18628520, PubMed:23132696). In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (By similarity). May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (By similarity). The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum (PubMed:12858176, PubMed:18628520, PubMed:23132696). By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity (PubMed:18628520). {ECO:0000250|UniProtKB:Q8CFX1, ECO:0000269|PubMed:12858176, ECO:0000269|PubMed:18628520, ECO:0000269|PubMed:23132696}.		glucose metabolic process [GO:0006006]; pentose-phosphate shunt, oxidative branch [GO:0009051]; regulation of cortisol biosynthetic process [GO:2000064]; response to alcohol [GO:0097305]; response to nutrient levels [GO:0031667]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	6-phosphogluconolactonase activity [GO:0017057]; carbohydrate binding [GO:0030246]; glucose 1-dehydrogenase (NAD+) activity [GO:0047934]; glucose 1-dehydrogenase (NADP+) activity [GO:0047935]; glucose 1-dehydrogenase [NAD(P)] activity [GO:0047936]; glucose-6-phosphate dehydrogenase activity [GO:0004345]; NADP binding [GO:0050661]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; 6-phosphogluconolactonase activity [GO:0017057]; carbohydrate binding [GO:0030246]; glucose 1-dehydrogenase (NAD+) activity [GO:0047934]; glucose 1-dehydrogenase (NADP+) activity [GO:0047935]; glucose 1-dehydrogenase [NAD(P)] activity [GO:0047936]; glucose-6-phosphate dehydrogenase activity [GO:0004345]; NADP binding [GO:0050661]; glucose metabolic process [GO:0006006]; pentose-phosphate shunt, oxidative branch [GO:0009051]; regulation of cortisol biosynthetic process [GO:2000064]; response to alcohol [GO:0097305]; response to nutrient levels [GO:0031667]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000305|PubMed:18628520}.
O95484	reviewed	CLD9_HUMAN	Claudin-9	CLDN9	Homo sapiens (Human)	217	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250|UniProtKB:O95832}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. {ECO:0000269|PubMed:17804490, ECO:0000269|PubMed:20375010}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; virus receptor activity [GO:0001618]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; virus receptor activity [GO:0001618]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane {ECO:0000269|PubMed:20375010, ECO:0000269|PubMed:31175426}; Multi-pass membrane protein {ECO:0000255}.
O95486	reviewed	SC24A_HUMAN	Protein transport protein Sec24A (SEC24-related protein A)	SEC24A	Homo sapiens (Human)	1093	FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:20427317, PubMed:17499046, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}.		cholesterol homeostasis [GO:0042632]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; positive regulation of protein secretion [GO:0050714]; regulation of cholesterol transport [GO:0032374]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]	SNARE binding [GO:0000149]; zinc ion binding [GO:0008270]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; SNARE binding [GO:0000149]; zinc ion binding [GO:0008270]; cholesterol homeostasis [GO:0042632]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; positive regulation of protein secretion [GO:0050714]; regulation of cholesterol transport [GO:0032374]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000305|PubMed:17499046}; Peripheral membrane protein {ECO:0000305|PubMed:17499046}; Cytoplasmic side {ECO:0000305|PubMed:17499046}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:17499046}; Peripheral membrane protein {ECO:0000305|PubMed:17499046}; Cytoplasmic side {ECO:0000305|PubMed:17499046}. Cytoplasm, cytosol {ECO:0000305|PubMed:17499046}.
O95487	reviewed	SC24B_HUMAN	Protein transport protein Sec24B (SEC24-related protein B)	SEC24B	Homo sapiens (Human)	1268	FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}.		aorta morphogenesis [GO:0035909]; auditory receptor cell stereocilium organization [GO:0060088]; cochlear nucleus development [GO:0021747]; COPII-coated vesicle cargo loading [GO:0090110]; coronary artery morphogenesis [GO:0060982]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; lung lobe morphogenesis [GO:0060463]; neural tube closure [GO:0001843]; outflow tract morphogenesis [GO:0003151]; pulmonary artery morphogenesis [GO:0061156]; regulation of cargo loading into COPII-coated vesicle [GO:1901301]; regulation of establishment of planar polarity involved in neural tube closure [GO:0090178]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]	SNARE binding [GO:0000149]; zinc ion binding [GO:0008270]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; SNARE binding [GO:0000149]; zinc ion binding [GO:0008270]; aorta morphogenesis [GO:0035909]; auditory receptor cell stereocilium organization [GO:0060088]; cochlear nucleus development [GO:0021747]; COPII-coated vesicle cargo loading [GO:0090110]; coronary artery morphogenesis [GO:0060982]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; lung lobe morphogenesis [GO:0060463]; neural tube closure [GO:0001843]; outflow tract morphogenesis [GO:0003151]; pulmonary artery morphogenesis [GO:0061156]; regulation of cargo loading into COPII-coated vesicle [GO:1901301]; regulation of establishment of planar polarity involved in neural tube closure [GO:0090178]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:10075675}; Peripheral membrane protein {ECO:0000305|PubMed:10075675}; Cytoplasmic side {ECO:0000305|PubMed:10075675}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10075675}; Peripheral membrane protein {ECO:0000269|PubMed:10075675}; Cytoplasmic side {ECO:0000269|PubMed:10075675}. Cytoplasm, cytosol {ECO:0000269|PubMed:10075675}.
O95490	reviewed	AGRL2_HUMAN	Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1)	ADGRL2 KIAA0786 LEC1 LPHH1 LPHN2	Homo sapiens (Human)	1459	FUNCTION: Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. {ECO:0000250|UniProtKB:O88923}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]	carbohydrate binding [GO:0030246]; G protein-coupled receptor activity [GO:0004930]; latrotoxin receptor activity [GO:0016524]	membrane [GO:0016020]; carbohydrate binding [GO:0030246]; G protein-coupled receptor activity [GO:0004930]; latrotoxin receptor activity [GO:0016524]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
O95497	reviewed	VNN1_HUMAN	Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1)	VNN1	Homo sapiens (Human)	513	FUNCTION: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. {ECO:0000269|PubMed:10567687, ECO:0000269|PubMed:11491533, ECO:0000269|PubMed:25478849}.		acute inflammatory response [GO:0002526]; cell-cell adhesion [GO:0098609]; chronic inflammatory response [GO:0002544]; coenzyme A catabolic process [GO:0015938]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; pantothenate metabolic process [GO:0015939]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of T cell differentiation in thymus [GO:0033089]; response to oxidative stress [GO:0006979]	azurophil granule membrane [GO:0035577]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	pantetheine hydrolase activity [GO:0017159]	azurophil granule membrane [GO:0035577]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; pantetheine hydrolase activity [GO:0017159]; acute inflammatory response [GO:0002526]; cell-cell adhesion [GO:0098609]; chronic inflammatory response [GO:0002544]; coenzyme A catabolic process [GO:0015938]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; pantothenate metabolic process [GO:0015939]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of T cell differentiation in thymus [GO:0033089]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:11491533}; Lipid-anchor, GPI-anchor {ECO:0000305}.
O95498	reviewed	VNN2_HUMAN	Pantetheine hydrolase VNN2 (EC 3.5.1.92) (Glycosylphosphatidyl inositol-anchored protein GPI-80) (Protein FOAP-4) (Vascular non-inflammatory molecule 2) (Vanin-2)	VNN2	Homo sapiens (Human)	520	FUNCTION: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine (PubMed:11491533). Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. {ECO:0000269|PubMed:11491533}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	pantothenate metabolic process [GO:0015939]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	pantetheine hydrolase activity [GO:0017159]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; pantetheine hydrolase activity [GO:0017159]; pantothenate metabolic process [GO:0015939]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
O95500	reviewed	CLD14_HUMAN	Claudin-14	CLDN14 UNQ777/PRO1571	Homo sapiens (Human)	239	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; protein-containing complex assembly [GO:0065003]	bicellular tight junction [GO:0005923]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
O95503	reviewed	CBX6_HUMAN	Chromobox protein homolog 6	CBX6	Homo sapiens (Human)	412	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}.	MISCELLANEOUS: The human orthologuous proteins of Drosophila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes.	chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]	chromatin [GO:0000785]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]	chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; single-stranded RNA binding [GO:0003727]	chromatin [GO:0000785]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; single-stranded RNA binding [GO:0003727]; chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18927235}. Chromosome {ECO:0000269|PubMed:18927235}. Note=Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235}.
O95528	reviewed	GTR10_HUMAN	Solute carrier family 2, facilitated glucose transporter member 10 (Glucose transporter type 10) (GLUT-10)	SLC2A10 GLUT10	Homo sapiens (Human)	541	FUNCTION: Facilitative glucose transporter required for the development of the cardiovascular system. {ECO:0000269|PubMed:11592815, ECO:0000269|PubMed:16550171}.		artery development [GO:0060840]; cell redox homeostasis [GO:0045454]; circulatory system development [GO:0072359]; dehydroascorbic acid transport [GO:0070837]; embryonic skeletal joint development [GO:0072498]; galactose transmembrane transport [GO:0015757]; glucose import across plasma membrane [GO:0098708]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; negative regulation of connective tissue growth factor production [GO:0032683]; negative regulation of gene expression [GO:0010629]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; negative regulation of proteoglycan biosynthetic process [GO:1902729]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of gene expression [GO:0010628]; positive regulation of proteoglycan biosynthetic process [GO:1902730]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of extracellular matrix organization [GO:1903053]; skin development [GO:0043588]; transport across blood-brain barrier [GO:0150104]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	carbohydrate:proton symporter activity [GO:0005351]; D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; symporter activity [GO:0015293]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; carbohydrate:proton symporter activity [GO:0005351]; D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; symporter activity [GO:0015293]; artery development [GO:0060840]; cell redox homeostasis [GO:0045454]; circulatory system development [GO:0072359]; dehydroascorbic acid transport [GO:0070837]; embryonic skeletal joint development [GO:0072498]; galactose transmembrane transport [GO:0015757]; glucose import across plasma membrane [GO:0098708]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; negative regulation of connective tissue growth factor production [GO:0032683]; negative regulation of gene expression [GO:0010629]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; negative regulation of proteoglycan biosynthetic process [GO:1902729]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of gene expression [GO:0010628]; positive regulation of proteoglycan biosynthetic process [GO:1902730]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of extracellular matrix organization [GO:1903053]; skin development [GO:0043588]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:16550171}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16550171}.
O95544	reviewed	NADK_HUMAN	NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase)	NADK	Homo sapiens (Human)	446			ATP metabolic process [GO:0046034]; NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741]; phosphorylation [GO:0016310]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	cytosol [GO:0005829]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; NAD+ kinase activity [GO:0003951]	cytosol [GO:0005829]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; NAD+ kinase activity [GO:0003951]; ATP metabolic process [GO:0046034]; NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741]; phosphorylation [GO:0016310]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	
O95551	reviewed	TYDP2_HUMAN	Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase)	TDP2 EAP2 TTRAP AD-022	Homo sapiens (Human)	362	FUNCTION: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (PubMed:27099339, PubMed:27060144). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. {ECO:0000269|PubMed:19794497, ECO:0000269|PubMed:21030584, ECO:0000269|PubMed:21921940, ECO:0000269|PubMed:21980489, ECO:0000269|PubMed:22405347, ECO:0000269|PubMed:22822062, ECO:0000269|PubMed:24658003, ECO:0000269|PubMed:27060144, ECO:0000269|PubMed:27099339}.; FUNCTION: (Microbial infection) Also acts as a 5'-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA. {ECO:0000269|PubMed:22908287}.		cell surface receptor signaling pathway [GO:0007166]; double-strand break repair [GO:0006302]; neuron development [GO:0048666]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	5'-tyrosyl-DNA phosphodiesterase activity [GO:0070260]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nuclease activity [GO:0004518]; single-stranded DNA binding [GO:0003697]; transcription corepressor activity [GO:0003714]; tyrosyl-RNA phosphodiesterase activity [GO:0036317]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; 5'-tyrosyl-DNA phosphodiesterase activity [GO:0070260]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nuclease activity [GO:0004518]; single-stranded DNA binding [GO:0003697]; transcription corepressor activity [GO:0003714]; tyrosyl-RNA phosphodiesterase activity [GO:0036317]; cell surface receptor signaling pathway [GO:0007166]; double-strand break repair [GO:0006302]; neuron development [GO:0048666]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12743594}. Nucleus, PML body {ECO:0000269|PubMed:19794497, ECO:0000269|PubMed:21921940}. Nucleus, nucleolus {ECO:0000269|PubMed:21921940}. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. {ECO:0000269|PubMed:21921940}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22908287}. Note=(Microbial infection) In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation. {ECO:0000269|PubMed:22908287}.
O95562	reviewed	SFT2B_HUMAN	Vesicle transport protein SFT2B (SFT2 domain-containing protein 2)	SFT2D2 UNQ512/PRO1027	Homo sapiens (Human)	160	FUNCTION: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. {ECO:0000250|UniProtKB:P38166}.		protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	extracellular exosome [GO:0070062]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; membrane [GO:0016020]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
O95563	reviewed	MPC2_HUMAN	Mitochondrial pyruvate carrier 2 (Brain protein 44)	MPC2 BRP44	Homo sapiens (Human)	127	FUNCTION: Mediates the uptake of pyruvate into mitochondria. {ECO:0000269|PubMed:22628558, ECO:0000269|PubMed:26253029, ECO:0000269|PubMed:27317664, ECO:0000269|PubMed:29472561}.		acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; mitochondrial pyruvate transmembrane transport [GO:0006850]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	inner mitochondrial membrane protein complex [GO:0098800]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; pyruvate transmembrane transporter activity [GO:0050833]	inner mitochondrial membrane protein complex [GO:0098800]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; pyruvate transmembrane transporter activity [GO:0050833]; acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; mitochondrial pyruvate transmembrane transport [GO:0006850]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:22628558, ECO:0000269|PubMed:26253029, ECO:0000269|PubMed:29472561}; Multi-pass membrane protein {ECO:0000255}.
O95568	reviewed	MET18_HUMAN	Histidine protein methyltransferase 1 homolog (EC 2.1.1.85) (Arsenic-transactivated protein 2) (AsTP2) (Methyltransferase-like protein 18)	METTL18 ASTP2 C1orf156	Homo sapiens (Human)	372	FUNCTION: Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation (PubMed:23349634, PubMed:33693809, PubMed:35674491). Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins (PubMed:35674491). {ECO:0000269|PubMed:23349634, ECO:0000269|PubMed:33693809, ECO:0000269|PubMed:35674491}.		peptidyl-lysine monomethylation [GO:0018026]; regulation of ribosome biogenesis [GO:0090069]; regulation of rRNA processing [GO:2000232]; regulation of translation [GO:0006417]; regulation of translational elongation [GO:0006448]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	heat shock protein binding [GO:0031072]; protein-L-histidine N-tele-methyltransferase activity [GO:0018064]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; heat shock protein binding [GO:0031072]; protein-L-histidine N-tele-methyltransferase activity [GO:0018064]; peptidyl-lysine monomethylation [GO:0018026]; regulation of ribosome biogenesis [GO:0090069]; regulation of rRNA processing [GO:2000232]; regulation of translation [GO:0006417]; regulation of translational elongation [GO:0006448]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:33693809}. Nucleus {ECO:0000269|PubMed:33693809}. Nucleus, nucleolus {ECO:0000269|PubMed:33693809}.
O95571	reviewed	ETHE1_HUMAN	Persulfide dioxygenase ETHE1, mitochondrial (EC 1.13.11.18) (Ethylmalonic encephalopathy protein 1) (Hepatoma subtracted clone one protein) (Sulfur dioxygenase ETHE1)	ETHE1 HSCO	Homo sapiens (Human)	254	FUNCTION: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897). {ECO:0000269|PubMed:12398897, ECO:0000269|PubMed:14732903, ECO:0000269|PubMed:19136963, ECO:0000269|PubMed:23144459}.		glutathione metabolic process [GO:0006749]; hydrogen sulfide metabolic process [GO:0070813]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; sulfur dioxygenase activity [GO:0050313]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; sulfur dioxygenase activity [GO:0050313]; glutathione metabolic process [GO:0006749]; hydrogen sulfide metabolic process [GO:0070813]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12398897}. Nucleus {ECO:0000269|PubMed:12398897}. Mitochondrion matrix {ECO:0000269|PubMed:14732903}.
O95573	reviewed	ACSL3_HUMAN	Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2)	ACSL3 ACS3 FACL3 LACS3	Homo sapiens (Human)	720	FUNCTION: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). {ECO:0000250|UniProtKB:Q63151, ECO:0000269|PubMed:18003621, ECO:0000269|PubMed:22633490}.		fatty acid metabolic process [GO:0006631]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; neuron differentiation [GO:0030182]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; positive regulation of secretion [GO:0051047]; very-low-density lipoprotein particle assembly [GO:0034379]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]	arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; palmitoyl-CoA ligase activity [GO:0090433]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]; arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; palmitoyl-CoA ligase activity [GO:0090433]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; neuron differentiation [GO:0030182]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; positive regulation of secretion [GO:0051047]; very-low-density lipoprotein particle assembly [GO:0034379]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
O95600	reviewed	KLF8_HUMAN	Krueppel-like factor 8 (Basic krueppel-like factor 3) (Zinc finger protein 741)	KLF8 BKLF3 ZNF741	Homo sapiens (Human)	359	FUNCTION: Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). {ECO:0000269|PubMed:10756197, ECO:0000269|PubMed:12820964, ECO:0000269|PubMed:16617055}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	aggresome [GO:0016235]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	aggresome [GO:0016235]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16617055}.
O95602	reviewed	RPA1_HUMAN	DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194)	POLR1A	Homo sapiens (Human)	1720	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). {ECO:0000250|UniProtKB:P10964}.		negative regulation of protein localization to nucleolus [GO:1904750]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA polymerase I activity [GO:0001054]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA polymerase I activity [GO:0001054]; negative regulation of protein localization to nucleolus [GO:1904750]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P10964}. Chromosome {ECO:0000250|UniProtKB:O35134}.
O95613	reviewed	PCNT_HUMAN	Pericentrin (Kendrin) (Pericentrin-B)	PCNT KIAA0402 PCNT2	Homo sapiens (Human)	3336	FUNCTION: Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}.		cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; positive regulation of intracellular protein transport [GO:0090316]; signal transduction [GO:0007165]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]	calmodulin binding [GO:0005516]; molecular adaptor activity [GO:0060090]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; calmodulin binding [GO:0005516]; molecular adaptor activity [GO:0060090]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; positive regulation of intracellular protein transport [GO:0090316]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:30420784}. Note=Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome.
O95619	reviewed	YETS4_HUMAN	YEATS domain-containing protein 4 (Glioma-amplified sequence 41) (Gas41) (NuMA-binding protein 1) (NuBI-1) (NuBI1)	YEATS4 GAS41	Homo sapiens (Human)	227	FUNCTION: Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12963728, PubMed:14966270). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed:29437725, PubMed:30071723, PubMed:29900004). Also able to recognize and bind crotonylated histone H3 (PubMed:30071723). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (PubMed:29463709). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (PubMed:29437725). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity). {ECO:0000250|UniProtKB:Q9CR11, ECO:0000269|PubMed:12963728, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:29437725, ECO:0000269|PubMed:29463709, ECO:0000269|PubMed:29900004, ECO:0000269|PubMed:30071723}.		chromatin remodeling [GO:0006338]; mitotic cell cycle [GO:0000278]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357]	NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; modification-dependent protein binding [GO:0140030]; structural constituent of cytoskeleton [GO:0005200]	NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; modification-dependent protein binding [GO:0140030]; structural constituent of cytoskeleton [GO:0005200]; chromatin remodeling [GO:0006338]; mitotic cell cycle [GO:0000278]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00376, ECO:0000269|PubMed:10913114, ECO:0000269|PubMed:18445686}.
O95622	reviewed	ADCY5_HUMAN	Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5)	ADCY5	Homo sapiens (Human)	1261	FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). {ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:24700542, ECO:0000269|PubMed:24740569, ECO:0000269|PubMed:26206488}.		adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cAMP biosynthetic process [GO:0006171]; cellular response to forskolin [GO:1904322]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; neuromuscular process controlling balance [GO:0050885]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]	cilium [GO:0005929]; membrane [GO:0016020]; plasma membrane [GO:0005886]	adenylate cyclase activity [GO:0004016]; adenylate cyclase binding [GO:0008179]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110]	cilium [GO:0005929]; membrane [GO:0016020]; plasma membrane [GO:0005886]; adenylate cyclase activity [GO:0004016]; adenylate cyclase binding [GO:0008179]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cAMP biosynthetic process [GO:0006171]; cellular response to forskolin [GO:1904322]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; neuromuscular process controlling balance [GO:0050885]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:15385642, ECO:0000305|PubMed:26206488}; Multi-pass membrane protein. Cell projection, cilium {ECO:0000250|UniProtKB:P84309}.
O95628	reviewed	CNOT4_HUMAN	CCR4-NOT transcription complex subunit 4 (EC 2.3.2.27) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) (RING-type E3 ubiquitin transferase CNOT4)	CNOT4 NOT4	Homo sapiens (Human)	575	FUNCTION: Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391). {ECO:0000269|PubMed:11823428, ECO:0000269|PubMed:22159038, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:29861391}.		nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of megakaryocyte differentiation [GO:0045652]; ubiquitin-dependent protein catabolic process [GO:0006511]	CCR4-NOT complex [GO:0030014]; cytosol [GO:0005829]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin-protein transferase activity [GO:0004842]	CCR4-NOT complex [GO:0030014]; cytosol [GO:0005829]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin-protein transferase activity [GO:0004842]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of megakaryocyte differentiation [GO:0045652]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
O95630	reviewed	STABP_HUMAN	STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase)	STAMBP AMSH	Homo sapiens (Human)	424	FUNCTION: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:15314065, PubMed:23542699, PubMed:34425109). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417). Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516). Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583). Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699). {ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699, ECO:0000269|PubMed:34425109}.	MISCELLANEOUS: X-ray crystallography studies of STAMBPL1, another member of the peptidase M67C family, has shown that Glu-280 binds zinc indirectly via a water molecule. Nevertheless, this residue is essential for catalytic activity. {ECO:0000250|UniProtKB:Q96FJ0}.	hippocampal neuron apoptotic process [GO:0110088]; mitotic cytokinesis [GO:0000281]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of cell population proliferation [GO:0008284]; protein deubiquitination [GO:0016579]; receptor signaling pathway via JAK-STAT [GO:0007259]	cleavage furrow [GO:0032154]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	deubiquitinase activity [GO:0101005]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; protein domain specific binding [GO:0019904]	cleavage furrow [GO:0032154]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; deubiquitinase activity [GO:0101005]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; protein domain specific binding [GO:0019904]; hippocampal neuron apoptotic process [GO:0110088]; mitotic cytokinesis [GO:0000281]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of cell population proliferation [GO:0008284]; protein deubiquitination [GO:0016579]; receptor signaling pathway via JAK-STAT [GO:0007259]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17261583, ECO:0000305|PubMed:10383417}. Membrane {ECO:0000269|PubMed:17261583}; Peripheral membrane protein {ECO:0000269|PubMed:17261583}. Cytoplasm {ECO:0000269|PubMed:17261583}. Early endosome {ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583}.
O95631	reviewed	NET1_HUMAN	Netrin-1 (Epididymis tissue protein Li 131P)	NTN1 NTN1L	Homo sapiens (Human)	604	FUNCTION: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335). {ECO:0000269|PubMed:15343335, ECO:0000269|PubMed:28483977}.		anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; Cdc42 protein signal transduction [GO:0032488]; cell-cell adhesion [GO:0098609]; chemorepulsion of axon [GO:0061643]; glial cell proliferation [GO:0014009]; inner ear morphogenesis [GO:0042472]; mammary gland duct morphogenesis [GO:0060603]; motor neuron migration [GO:0097475]; negative regulation of axon extension [GO:0030517]; nuclear migration [GO:0007097]; positive regulation of axon extension [GO:0045773]; positive regulation of cell motility [GO:2000147]; positive regulation of glial cell proliferation [GO:0060252]; Ras protein signal transduction [GO:0007265]; regulation of glial cell migration [GO:1903975]; regulation of synapse assembly [GO:0051963]; regulation of transcription by RNA polymerase II [GO:0006357]; substrate-dependent cell migration, cell extension [GO:0006930]	actin cytoskeleton [GO:0015629]; basement membrane [GO:0005604]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	actin cytoskeleton [GO:0015629]; basement membrane [GO:0005604]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; Cdc42 protein signal transduction [GO:0032488]; cell-cell adhesion [GO:0098609]; chemorepulsion of axon [GO:0061643]; glial cell proliferation [GO:0014009]; inner ear morphogenesis [GO:0042472]; mammary gland duct morphogenesis [GO:0060603]; motor neuron migration [GO:0097475]; negative regulation of axon extension [GO:0030517]; nuclear migration [GO:0007097]; positive regulation of axon extension [GO:0045773]; positive regulation of cell motility [GO:2000147]; positive regulation of glial cell proliferation [GO:0060252]; Ras protein signal transduction [GO:0007265]; regulation of glial cell migration [GO:1903975]; regulation of synapse assembly [GO:0051963]; regulation of transcription by RNA polymerase II [GO:0006357]; substrate-dependent cell migration, cell extension [GO:0006930]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28945198}. Cytoplasm {ECO:0000269|PubMed:28945198}. Note=Mainly secreted. {ECO:0000269|PubMed:28945198}.
O95633	reviewed	FSTL3_HUMAN	Follistatin-related protein 3 (Follistatin-like protein 3) (Follistatin-related gene protein)	FSTL3 FLRG UNQ674/PRO1308	Homo sapiens (Human)	263	FUNCTION: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. {ECO:0000269|PubMed:11948405, ECO:0000269|PubMed:15451575, ECO:0000269|PubMed:15574124, ECO:0000269|PubMed:16336961, ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:17878677}.		cell differentiation [GO:0030154]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0090101]; ossification [GO:0001503]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of BMP signaling pathway [GO:0030510]; regulation of transcription by RNA polymerase II [GO:0006357]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	activin binding [GO:0048185]; fibronectin binding [GO:0001968]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; activin binding [GO:0048185]; fibronectin binding [GO:0001968]; cell differentiation [GO:0030154]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0090101]; ossification [GO:0001503]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of BMP signaling pathway [GO:0030510]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Note=Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to. {ECO:0000269|PubMed:16150905}.
O95639	reviewed	CPSF4_HUMAN	Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog)	CPSF4 CPSF30 NAR NEB1	Homo sapiens (Human)	269	FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:9224719}.	MISCELLANEOUS: [Isoform 3]: May be due to a competing acceptor splice site. {ECO:0000305}.	mRNA processing [GO:0006397]	intracellular membrane-bounded organelle [GO:0043231]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	intracellular membrane-bounded organelle [GO:0043231]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; mRNA processing [GO:0006397]	SUBCELLULAR LOCATION: Nucleus.
O95644	reviewed	NFAC1_HUMAN	Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)	NFATC1 NFAT2 NFATC	Homo sapiens (Human)	943	FUNCTION: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}.	MISCELLANEOUS: [Isoform A-alpha']: Produced by alternative initiation at Met-37 of isoform A-alpha. {ECO:0000305}.	aortic valve morphogenesis [GO:0003180]; calcineurin-NFAT signaling cascade [GO:0033173]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; intracellular signal transduction [GO:0035556]; mononuclear cell differentiation [GO:1903131]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary valve morphogenesis [GO:0003184]; regulation of transcription by RNA polymerase II [GO:0006357]; response to muscle activity [GO:0014850]; skeletal muscle adaptation [GO:0043501]; wound healing [GO:0042060]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasm [GO:0016528]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; FK506 binding [GO:0005528]; mitogen-activated protein kinase p38 binding [GO:0048273]; nucleic acid binding [GO:0003676]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasm [GO:0016528]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; FK506 binding [GO:0005528]; mitogen-activated protein kinase p38 binding [GO:0048273]; nucleic acid binding [GO:0003676]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]; aortic valve morphogenesis [GO:0003180]; calcineurin-NFAT signaling cascade [GO:0033173]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; intracellular signal transduction [GO:0035556]; mononuclear cell differentiation [GO:1903131]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary valve morphogenesis [GO:0003184]; regulation of transcription by RNA polymerase II [GO:0006357]; response to muscle activity [GO:0014850]; skeletal muscle adaptation [GO:0043501]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16511445}. Nucleus {ECO:0000269|PubMed:16511445}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription (PubMed:16511445). Nuclear translocation of NFATC1 is enhanced in the presence of TNFSF11. Nuclear translocation is decreased in the presence of FBN1 which can bind and sequester TNFSF11 (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:16511445}.
O95670	reviewed	VATG2_HUMAN	V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (V-ATPase 13 kDa subunit 2) (Vacuolar proton pump subunit G 2)	ATP6V1G2 ATP6G ATP6G2 NG38	Homo sapiens (Human)	118	FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. {ECO:0000250|UniProtKB:O75348}.		regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]	clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; melanosome [GO:0042470]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	ATP hydrolysis activity [GO:0016887]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; melanosome [GO:0042470]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]; ATP hydrolysis activity [GO:0016887]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]	SUBCELLULAR LOCATION: Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q0VCV6}; Peripheral membrane protein {ECO:0000305}. Note=Highly enriched in late-stage melanosomes. {ECO:0000269|PubMed:17081065}.
O95671	reviewed	ASML_HUMAN	Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)]	ASMTL	Homo sapiens (Human)	621	FUNCTION: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). {ECO:0000269|PubMed:24210219, ECO:0000305}.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It represents a unique fusion product of 2 different genes of different evolutionary origin and function. The N-terminus is homologous to the bacterial maf/orfE genes and the C-terminus is homologous to ASMT. Exon duplication, exon shuffling and gene fusion seem to be common characteristics of the PAR1 region.	methylation [GO:0032259]; nucleotide metabolic process [GO:0009117]	cytosol [GO:0005829]	dTTP diphosphatase activity [GO:0036218]; nucleoside triphosphate diphosphatase activity [GO:0047429]; O-methyltransferase activity [GO:0008171]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; UTP diphosphatase activity [GO:0036221]	cytosol [GO:0005829]; dTTP diphosphatase activity [GO:0036218]; nucleoside triphosphate diphosphatase activity [GO:0047429]; O-methyltransferase activity [GO:0008171]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; UTP diphosphatase activity [GO:0036221]; methylation [GO:0032259]; nucleotide metabolic process [GO:0009117]	
O95672	reviewed	ECEL1_HUMAN	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein)	ECEL1 XCE UNQ2431/PRO4991	Homo sapiens (Human)	775	FUNCTION: May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.		neuropeptide signaling pathway [GO:0007218]; protein processing [GO:0016485]; respiratory system process [GO:0003016]	plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; neuropeptide signaling pathway [GO:0007218]; protein processing [GO:0016485]; respiratory system process [GO:0003016]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
O95674	reviewed	CDS2_HUMAN	Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2)	CDS2	Homo sapiens (Human)	445	FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}.		CDP-diacylglycerol biosynthetic process [GO:0016024]; lipid droplet formation [GO:0140042]; phosphatidylglycerol biosynthetic process [GO:0006655]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]	phosphatidate cytidylyltransferase activity [GO:0004605]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; phosphatidate cytidylyltransferase activity [GO:0004605]; CDP-diacylglycerol biosynthetic process [GO:0016024]; lipid droplet formation [GO:0140042]; phosphatidylglycerol biosynthetic process [GO:0006655]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}; Multi-pass membrane protein {ECO:0000255}.
O95677	reviewed	EYA4_HUMAN	Eyes absent homolog 4 (EC 3.1.3.48)	EYA4	Homo sapiens (Human)	639	FUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250|UniProtKB:Q99502}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; DNA repair [GO:0006281]; inner ear development [GO:0048839]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of DNA repair [GO:0045739]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725]; anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; DNA repair [GO:0006281]; inner ear development [GO:0048839]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of DNA repair [GO:0045739]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99502}. Nucleus {ECO:0000250|UniProtKB:Q99502}.
O95678	reviewed	K2C75_HUMAN	Keratin, type II cytoskeletal 75 (Cytokeratin-75) (CK-75) (Keratin-6 hair follicle) (hK6hf) (Keratin-75) (K75) (Type II keratin-K6hf) (Type-II keratin Kb18)	KRT75 K6HF KB18	Homo sapiens (Human)	551	FUNCTION: Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.	MISCELLANEOUS: May be used as a marker of hair differentiation.; MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	hematopoietic progenitor cell differentiation [GO:0002244]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]; structural molecule activity [GO:0005198]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; structural molecule activity [GO:0005198]; hematopoietic progenitor cell differentiation [GO:0002244]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
O95684	reviewed	CEP43_HUMAN	Centrosomal protein 43 (FGFR1 oncogene partner)	CEP43 FGFR1OP FOP	Homo sapiens (Human)	399	FUNCTION: Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}.		cell projection organization [GO:0030030]; microtubule anchoring [GO:0034453]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]	cell projection [GO:0042995]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein tyrosine kinase inhibitor activity [GO:0030292]	cell projection [GO:0042995]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein tyrosine kinase inhibitor activity [GO:0030292]; cell projection organization [GO:0030030]; microtubule anchoring [GO:0034453]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:16690081, ECO:0000269|PubMed:28659385}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28659385}. Note=Associated with gamma-tubulin (PubMed:16314388). Localizes on both mother and daughter centrioles (PubMed:28625565, PubMed:28428259). Localizes to an axial position on the mother centriole (PubMed:28625565). Localizes to the distal end of the centriole partly on the subdistal appendage region (PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}.
O95696	reviewed	BRD1_HUMAN	Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2)	BRD1 BRL BRPF2	Homo sapiens (Human)	1058	FUNCTION: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}.		chromatin remodeling [GO:0006338]; erythrocyte maturation [GO:0043249]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357]; response to electrical stimulus [GO:0051602]; response to immobilization stress [GO:0035902]	dendrite [GO:0030425]; histone H3-K14 acetyltransferase complex [GO:0036409]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perikaryon [GO:0043204]	histone binding [GO:0042393]; histone reader activity [GO:0140566]; metal ion binding [GO:0046872]	dendrite [GO:0030425]; histone H3-K14 acetyltransferase complex [GO:0036409]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perikaryon [GO:0043204]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; metal ion binding [GO:0046872]; chromatin remodeling [GO:0006338]; erythrocyte maturation [GO:0043249]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357]; response to electrical stimulus [GO:0051602]; response to immobilization stress [GO:0035902]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731, ECO:0000269|PubMed:25593309}. Chromosome {ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:28334966}. Note=Localizes to transcription start sites. {ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:28334966}.
O95704	reviewed	APBB3_HUMAN	Amyloid-beta A4 precursor protein-binding family B member 3 (Protein Fe65-like 2) (Fe65L2)	APBB3 FE65L2	Homo sapiens (Human)	486	FUNCTION: May modulate the internalization of amyloid-beta precursor protein.	MISCELLANEOUS: [Isoform I-214]: Increased expression upon apoptotic stimuli. {ECO:0000305}.	positive regulation of protein secretion [GO:0050714]; regulation of DNA-templated transcription [GO:0006355]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleus [GO:0005634]	amyloid-beta binding [GO:0001540]; low-density lipoprotein particle receptor binding [GO:0050750]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleus [GO:0005634]; amyloid-beta binding [GO:0001540]; low-density lipoprotein particle receptor binding [GO:0050750]; positive regulation of protein secretion [GO:0050714]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12153398}. Nucleus {ECO:0000269|PubMed:12153398}.; SUBCELLULAR LOCATION: [Isoform I-214]: Nucleus.; SUBCELLULAR LOCATION: [Isoform I-245]: Nucleus.
O95707	reviewed	RPP29_HUMAN	Ribonuclease P protein subunit p29 (hPOP4)	POP4 RPP29	Homo sapiens (Human)	220	FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. {ECO:0000269|PubMed:10024167, ECO:0000269|PubMed:10352175, ECO:0000269|PubMed:30454648}.		rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]	multimeric ribonuclease P complex [GO:0030681]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]; ribonuclease P complex [GO:0030677]	ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]	multimeric ribonuclease P complex [GO:0030681]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]; ribonuclease P complex [GO:0030677]; ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10352175}.
O95711	reviewed	LY86_HUMAN	Lymphocyte antigen 86 (Ly-86) (Protein MD-1)	LY86 MD1	Homo sapiens (Human)	162	FUNCTION: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity). {ECO:0000250}.		inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]	SUBCELLULAR LOCATION: Secreted, extracellular space. Note=Associated with CD180 at the cell surface.
O95714	reviewed	HERC2_HUMAN	E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)	HERC2	Homo sapiens (Human)	4834	FUNCTION: E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Modulates also iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}.	MISCELLANEOUS: A regulatory element withinin an intron of the HERC2 gene inhibits OCA2 promoter. There are several single nucleotide polymorphisms within the OCA2 gene and within the HERC2 gene that have a statistical association with human eye color.	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; intracellular protein transport [GO:0006886]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; SUMO binding [GO:0032183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; SUMO binding [GO:0032183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; intracellular protein transport [GO:0006886]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Recruited to sites of DNA damage in response to ionizing radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis.
O95715	reviewed	CXL14_HUMAN	C-X-C motif chemokine 14 (Chemokine BRAK) (MIP-2G) (Small-inducible cytokine B14)	CXCL14 MIP2G NJAC SCYB14 PSEC0212 UNQ240/PRO273	Homo sapiens (Human)	111	FUNCTION: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. {ECO:0000269|PubMed:10049774, ECO:0000269|PubMed:10946286}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; chemotaxis [GO:0006935]; signal transduction [GO:0007165]	extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]	chemokine activity [GO:0008009]	extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; chemokine activity [GO:0008009]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; chemotaxis [GO:0006935]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
O95716	reviewed	RAB3D_HUMAN	Ras-related protein Rab-3D	RAB3D GOV RAB16	Homo sapiens (Human)	219	FUNCTION: Protein transport. Probably involved in regulated exocytosis (By similarity). {ECO:0000250}.		bone resorption [GO:0045453]; positive regulation of regulated secretory pathway [GO:1903307]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904]	azurophil granule membrane [GO:0035577]; cytoplasmic microtubule [GO:0005881]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; secretory vesicle [GO:0099503]; synaptic vesicle [GO:0008021]; zymogen granule [GO:0042588]	GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]	azurophil granule membrane [GO:0035577]; cytoplasmic microtubule [GO:0005881]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; secretory vesicle [GO:0099503]; synaptic vesicle [GO:0008021]; zymogen granule [GO:0042588]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; bone resorption [GO:0045453]; positive regulation of regulated secretory pathway [GO:1903307]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
O95718	reviewed	ERR2_HUMAN	Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)	ESRRB ERRB2 ESRL2 NR3B2	Homo sapiens (Human)	433	FUNCTION: [Isoform 3]: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186, PubMed:19755138). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity). {ECO:0000250|UniProtKB:Q61539, ECO:0000269|PubMed:17920186, ECO:0000269|PubMed:19755138, ECO:0000269|PubMed:23836911}.; FUNCTION: [Isoform 1]: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Positively regulates ESR1 transcriptional activity upon E2 stimulation. {ECO:0000269|PubMed:19755138}.	MISCELLANEOUS: [Isoform 1]: Primate-specific splicing isoform. {ECO:0000303|PubMed:16332939}.; MISCELLANEOUS: [Isoform 2]: Primate-specific splicing isoform. {ECO:0000303|PubMed:16332939}.	cell dedifferentiation [GO:0043697]; cell population proliferation [GO:0008283]; inner ear development [GO:0048839]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; negative regulation of stem cell differentiation [GO:2000737]; photoreceptor cell maintenance [GO:0045494]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071931]; positive regulation of transcription involved in G2/M transition of mitotic cell cycle [GO:0090282]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell division [GO:2000035]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell division [GO:0017145]; stem cell population maintenance [GO:0019827]	chromatin [GO:0000785]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]; cell dedifferentiation [GO:0043697]; cell population proliferation [GO:0008283]; inner ear development [GO:0048839]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; negative regulation of stem cell differentiation [GO:2000737]; photoreceptor cell maintenance [GO:0045494]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071931]; positive regulation of transcription involved in G2/M transition of mitotic cell cycle [GO:0090282]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell division [GO:2000035]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell division [GO:0017145]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18775884}. Cytoplasm {ECO:0000250|UniProtKB:Q61539}. Chromosome {ECO:0000250|UniProtKB:Q61539}.
O95721	reviewed	SNP29_HUMAN	Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29)	SNAP29	Homo sapiens (Human)	258	FUNCTION: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}.		autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; cilium assembly [GO:0060271]; exocytosis [GO:0006887]; membrane fusion [GO:0061025]; protein transport [GO:0015031]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]; vesicle targeting [GO:0006903]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; azurophil granule membrane [GO:0035577]; centrosome [GO:0005813]; ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201]	SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; azurophil granule membrane [GO:0035577]; centrosome [GO:0005813]; ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201]; SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]; autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; cilium assembly [GO:0060271]; exocytosis [GO:0006887]; membrane fusion [GO:0061025]; protein transport [GO:0015031]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]; vesicle targeting [GO:0006903]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23217709}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Z2P6}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:25686604}; Peripheral membrane protein {ECO:0000305}. Cell projection, cilium membrane {ECO:0000269|PubMed:25686250}; Peripheral membrane protein {ECO:0000305}. Note=Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic. Localizes to the ciliary pocket from where the cilium protrudes. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250}.
O95727	reviewed	CRTAM_HUMAN	Cytotoxic and regulatory T-cell molecule (Class-I MHC-restricted T-cell-associated molecule) (CD antigen CD355)	CRTAM	Homo sapiens (Human)	393	FUNCTION: Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). {ECO:0000250|UniProtKB:Q149L7, ECO:0000269|PubMed:15811952}.		adaptive immune response [GO:0002250]; cell recognition [GO:0008037]; detection of stimulus [GO:0051606]; detection of tumor cell [GO:0002355]; establishment of T cell polarity [GO:0001768]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; lymphocyte migration into lymphoid organs [GO:0097021]; negative regulation of activated T cell proliferation [GO:0046007]; positive regulation of cytokine production [GO:0001819]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of type II interferon production [GO:0032729]; regulation of CD8-positive, alpha-beta T cell activation [GO:2001185]; regulation of T cell activation [GO:0050863]; regulation of T cell differentiation [GO:0045580]	immunological synapse [GO:0001772]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]	immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; adaptive immune response [GO:0002250]; cell recognition [GO:0008037]; detection of stimulus [GO:0051606]; detection of tumor cell [GO:0002355]; establishment of T cell polarity [GO:0001768]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; lymphocyte migration into lymphoid organs [GO:0097021]; negative regulation of activated T cell proliferation [GO:0046007]; positive regulation of cytokine production [GO:0001819]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of type II interferon production [GO:0032729]; regulation of CD8-positive, alpha-beta T cell activation [GO:2001185]; regulation of T cell activation [GO:0050863]; regulation of T cell differentiation [GO:0045580]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q149L7}; Single-pass type I membrane protein {ECO:0000255}. Note=In a subset of CD4+ T-cells, colocalizes with SCRIB at the immunological synapse during the late phase of T-cell activation. {ECO:0000250|UniProtKB:Q149L7}.
O95741	reviewed	CPNE6_HUMAN	Copine-6 (Copine VI) (Neuronal-copine) (N-copine)	CPNE6	Homo sapiens (Human)	557	FUNCTION: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q9Z140, ECO:0000269|PubMed:23999003}.		cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]; postsynaptic actin cytoskeleton organization [GO:0098974]	axon [GO:0030424]; clathrin-coated endocytic vesicle [GO:0045334]; dendrite [GO:0030425]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786]	axon [GO:0030424]; clathrin-coated endocytic vesicle [GO:0045334]; dendrite [GO:0030425]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]; postsynaptic actin cytoskeleton organization [GO:0098974]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z140}. Cell membrane {ECO:0000250|UniProtKB:Q9Z140}. Endosome {ECO:0000250|UniProtKB:Q9Z140}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q9Z140}. Perikaryon {ECO:0000250|UniProtKB:Q9Z140}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Z140}. Note=Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to the cell membrane in a calcium-dependent manner. Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner. {ECO:0000250|UniProtKB:Q9Z140}.
O95747	reviewed	OXSR1_HUMAN	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein)	OXSR1 KIAA1101 OSR1	Homo sapiens (Human)	527	FUNCTION: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328, PubMed:17721439). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}.		cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular hypotonic response [GO:0071476]; cellular response to chemokine [GO:1990869]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; intracellular signal transduction [GO:0035556]; negative regulation of potassium ion transmembrane transport [GO:1901380]; osmosensory signaling pathway [GO:0007231]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of T cell chemotaxis [GO:0010820]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; renal sodium ion absorption [GO:0070294]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular hypotonic response [GO:0071476]; cellular response to chemokine [GO:1990869]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; intracellular signal transduction [GO:0035556]; negative regulation of potassium ion transmembrane transport [GO:1901380]; osmosensory signaling pathway [GO:0007231]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of T cell chemotaxis [GO:0010820]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; renal sodium ion absorption [GO:0070294]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22361696, ECO:0000269|PubMed:22989884}.
O95749	reviewed	GGPPS_HUMAN	Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)	GGPS1	Homo sapiens (Human)	300	FUNCTION: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. {ECO:0000269|PubMed:32403198}.		farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384]; geranylgeranyl diphosphate biosynthetic process [GO:0033386]; isoprenoid biosynthetic process [GO:0008299]; isoprenoid metabolic process [GO:0006720]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018]	dimethylallyltranstransferase activity [GO:0004161]; farnesyltranstransferase activity [GO:0004311]; geranyltranstransferase activity [GO:0004337]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; prenyltransferase activity [GO:0004659]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018]; dimethylallyltranstransferase activity [GO:0004161]; farnesyltranstransferase activity [GO:0004311]; geranyltranstransferase activity [GO:0004337]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; prenyltransferase activity [GO:0004659]; farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384]; geranylgeranyl diphosphate biosynthetic process [GO:0033386]; isoprenoid biosynthetic process [GO:0008299]; isoprenoid metabolic process [GO:0006720]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32403198}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:32403198}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:32403198}.
O95750	reviewed	FGF19_HUMAN	Fibroblast growth factor 19 (FGF-19)	FGF19 UNQ334/PRO533	Homo sapiens (Human)	216	FUNCTION: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. {ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:19085950}.	MISCELLANEOUS: Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for FGFR4.	animal organ morphogenesis [GO:0009887]; bile acid and bile salt transport [GO:0015721]; cell differentiation [GO:0030154]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart development [GO:0007507]; negative regulation of bile acid biosynthetic process [GO:0070858]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]; response to bacterium [GO:0009617]; response to ethanol [GO:0045471]; response to organic cyclic compound [GO:0014070]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; animal organ morphogenesis [GO:0009887]; bile acid and bile salt transport [GO:0015721]; cell differentiation [GO:0030154]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart development [GO:0007507]; negative regulation of bile acid biosynthetic process [GO:0070858]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]; response to bacterium [GO:0009617]; response to ethanol [GO:0045471]; response to organic cyclic compound [GO:0014070]	SUBCELLULAR LOCATION: Secreted.
O95751	reviewed	LDOC1_HUMAN	Protein LDOC1 (Leucine zipper protein down-regulated in cancer cells)	LDOC1 BCUR1	Homo sapiens (Human)	146	FUNCTION: May have an important role in the development and/or progression of some cancers.		cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; maternal placenta development [GO:0001893]; maternal process involved in parturition [GO:0060137]; negative regulation of cell population proliferation [GO:0008285]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; maternal placenta development [GO:0001893]; maternal process involved in parturition [GO:0060137]; negative regulation of cell population proliferation [GO:0008285]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10403563}.
O95754	reviewed	SEM4F_HUMAN	Semaphorin-4F (Semaphorin-M) (Sema M) (Semaphorin-W) (Sema W)	SEMA4F SEMAM SEMAW	Homo sapiens (Human)	770	FUNCTION: Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity). Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal ganglion-cell axons (By similarity). {ECO:0000250|UniProtKB:Q9Z123, ECO:0000250|UniProtKB:Q9Z143}.		axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; retinal ganglion cell axon guidance [GO:0031290]; semaphorin-plexin signaling pathway [GO:0071526]	dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; retinal ganglion cell axon guidance [GO:0031290]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000250|UniProtKB:Q9Z143}. Perikaryon {ECO:0000250|UniProtKB:Q9Z123}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Z123}. Note=Colocalizes with DLG4 at synapses. {ECO:0000250|UniProtKB:Q9Z123}.
O95758	reviewed	PTBP3_HUMAN	Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1)	PTBP3 ROD1	Homo sapiens (Human)	552	FUNCTION: RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}.		anatomical structure morphogenesis [GO:0009653]; erythrocyte maturation [GO:0043249]; mRNA processing [GO:0006397]; negative regulation of RNA splicing [GO:0033119]; regulation of cell differentiation [GO:0045595]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	nucleus [GO:0005634]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; anatomical structure morphogenesis [GO:0009653]; erythrocyte maturation [GO:0043249]; mRNA processing [GO:0006397]; negative regulation of RNA splicing [GO:0033119]; regulation of cell differentiation [GO:0045595]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	
O95760	reviewed	IL33_HUMAN	Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)]	IL33 C9orf26 IL1F11 NFHEV	Homo sapiens (Human)	270	FUNCTION: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016, PubMed:19841166). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines (PubMed:17853410, PubMed:18836528). Also involved in activation of mast cells, basophils, eosinophils and natural killer cells (PubMed:17853410, PubMed:18836528). Acts as an enhancer of polarization of alternatively activated macrophages (PubMed:19841166). Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). {ECO:0000250|UniProtKB:Q8BVZ5, ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:17853410, ECO:0000269|PubMed:18836528, ECO:0000269|PubMed:19841166}.; FUNCTION: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or pro-inflammatory activation (PubMed:18787100). {ECO:0000269|PubMed:18787100, ECO:0000269|PubMed:21734074}.	MISCELLANEOUS: [Isoform 3]: Constitutively active. {ECO:0000305}.	cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; gene expression [GO:0010467]; interleukin-33-mediated signaling pathway [GO:0038172]; macrophage differentiation [GO:0030225]; microglial cell activation involved in immune response [GO:0002282]; microglial cell proliferation [GO:0061518]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of macrophage proliferation [GO:0120042]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; positive regulation of CD80 production [GO:0150145]; positive regulation of CD86 production [GO:0150142]; positive regulation of cellular defense response [GO:0010186]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage activation [GO:0043032]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type 2 immune response [GO:0002830]; protein import into nucleus [GO:0006606]; type 2 immune response [GO:0042092]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transport vesicle [GO:0030133]	cytokine activity [GO:0005125]; interleukin-33 receptor binding [GO:0002112]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transport vesicle [GO:0030133]; cytokine activity [GO:0005125]; interleukin-33 receptor binding [GO:0002112]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; gene expression [GO:0010467]; interleukin-33-mediated signaling pathway [GO:0038172]; macrophage differentiation [GO:0030225]; microglial cell activation involved in immune response [GO:0002282]; microglial cell proliferation [GO:0061518]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of macrophage proliferation [GO:0120042]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; positive regulation of CD80 production [GO:0150145]; positive regulation of CD86 production [GO:0150142]; positive regulation of cellular defense response [GO:0010186]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage activation [GO:0043032]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type 2 immune response [GO:0002830]; protein import into nucleus [GO:0006606]; type 2 immune response [GO:0042092]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12819012, ECO:0000269|PubMed:17185418, ECO:0000269|PubMed:18787100, ECO:0000269|PubMed:18836528, ECO:0000269|PubMed:21734074}. Chromosome {ECO:0000269|PubMed:17185418}. Cytoplasm {ECO:0000269|PubMed:32272059}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:22215666}. Secreted {ECO:0000269|PubMed:19465481, ECO:0000269|PubMed:35794369}. Note=Secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore following cleavage by CELA1 (PubMed:35794369). Associates with heterochromatin and mitotic chromosomes (PubMed:17185418). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). {ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:35794369}.
O95772	reviewed	STR3N_HUMAN	STARD3 N-terminal-like protein (MLN64 N-terminal domain homolog)	STARD3NL MENTHO UNQ855/PRO1864	Homo sapiens (Human)	234	FUNCTION: Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). {ECO:0000269|PubMed:24105263}.		cholesterol transport [GO:0030301]; vesicle tethering to endoplasmic reticulum [GO:0099044]	cytosol [GO:0005829]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; organelle membrane contact site [GO:0044232]	cholesterol binding [GO:0015485]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; organelle membrane contact site [GO:0044232]; cholesterol binding [GO:0015485]; protein homodimerization activity [GO:0042803]; cholesterol transport [GO:0030301]; vesicle tethering to endoplasmic reticulum [GO:0099044]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:24105263, ECO:0000269|PubMed:29858488}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA, VAPB or MOSPD2. {ECO:0000269|PubMed:24105263}.
O95777	reviewed	LSM8_HUMAN	U6 snRNA-associated Sm-like protein LSm8	LSM8	Homo sapiens (Human)	96	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.		mRNA splicing, via spliceosome [GO:0000398]	Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]	RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070]	Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
O95782	reviewed	AP2A1_HUMAN	AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)	AP2A1 ADTAA CLAPA1	Homo sapiens (Human)	977	FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}.		clathrin-dependent endocytosis [GO:0072583]; endocytosis [GO:0006897]; Golgi to endosome transport [GO:0006895]; intracellular protein transport [GO:0006886]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; positive regulation of neuron projection development [GO:0010976]; positive regulation of receptor-mediated endocytosis [GO:0048260]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; vesicle-mediated transport [GO:0016192]	AP-2 adaptor complex [GO:0030122]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; filopodium tip [GO:0032433]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	clathrin adaptor activity [GO:0035615]; low-density lipoprotein particle receptor binding [GO:0050750]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]	AP-2 adaptor complex [GO:0030122]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; filopodium tip [GO:0032433]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; clathrin adaptor activity [GO:0035615]; low-density lipoprotein particle receptor binding [GO:0050750]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; clathrin-dependent endocytosis [GO:0072583]; endocytosis [GO:0006897]; Golgi to endosome transport [GO:0006895]; intracellular protein transport [GO:0006886]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; positive regulation of neuron projection development [GO:0010976]; positive regulation of receptor-mediated endocytosis [GO:0048260]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16262731}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250}.
O95785	reviewed	WIZ_HUMAN	Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803)	WIZ ZNF803	Homo sapiens (Human)	1651	FUNCTION: May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}.		positive regulation of nuclear cell cycle DNA replication [GO:0010571]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]	extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]	extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
O95786	reviewed	RIGI_HUMAN	Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)	RIGI DDX58	Homo sapiens (Human)	925	FUNCTION: Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624, PubMed:16125763, PubMed:15708988, PubMed:16127453, PubMed:16153868, PubMed:17190814, PubMed:18636086, PubMed:19122199, PubMed:19211564, PubMed:29117565, PubMed:28469175, PubMed:31006531, PubMed:34935440, PubMed:35263596, PubMed:36793726). Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments (PubMed:15208624, PubMed:15708988). The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531). Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length) (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV) (PubMed:21616437, PubMed:21884169). It also detects rotaviruses and reoviruses (PubMed:21616437, PubMed:21884169). Detects and binds to SARS-CoV-2 RNAs which is inhibited by m6A RNA modifications (Ref.68). Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV) (PubMed:19631370). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration. {ECO:0000269|PubMed:15208624, ECO:0000269|PubMed:15708988, ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:17190814, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19122199, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19576794, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:31006531, ECO:0000269|PubMed:34935440, ECO:0000269|PubMed:35263596, ECO:0000269|PubMed:36793726, ECO:0000269|Ref.68, ECO:0000303|PubMed:21616437, ECO:0000303|PubMed:21884169}.		antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; gene expression [GO:0010467]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell migration [GO:0030334]; regulation of type III interferon production [GO:0034344]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529]	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]; ruffle membrane [GO:0032587]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]; ruffle membrane [GO:0032587]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; gene expression [GO:0010467]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell migration [GO:0030334]; regulation of type III interferon production [GO:0034344]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529]	SUBCELLULAR LOCATION: Cytoplasm. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cell junction, tight junction. Note=Colocalized with TRIM25 at cytoplasmic perinuclear bodies. Associated with the actin cytoskeleton at membrane ruffles.
O95789	reviewed	ZMYM6_HUMAN	Zinc finger MYM-type protein 6 (Transposon-derived Buster2 transposase-like protein) (Zinc finger protein 258)	ZMYM6 Buster2 KIAA1353 ZNF258	Homo sapiens (Human)	1325	FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.		cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]	nucleus [GO:0005634]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O95793	reviewed	STAU1_HUMAN	Double-stranded RNA-binding protein Staufen homolog 1	STAU1 STAU	Homo sapiens (Human)	577	FUNCTION: Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.; FUNCTION: (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process. {ECO:0000269|PubMed:10325410, ECO:0000269|PubMed:18498651, ECO:0000269|PubMed:23926355, ECO:0000269|PubMed:30301857}.		anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; cellular response to oxidative stress [GO:0034599]; germ cell development [GO:0007281]; intracellular mRNA localization [GO:0008298]; lncRNA-mediated post-transcriptional gene silencing [GO:0000512]; modification of postsynaptic structure [GO:0099010]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of viral genome replication [GO:0045070]; protein localization to synapse [GO:0035418]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; messenger ribonucleoprotein complex [GO:1990124]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]	double-stranded RNA binding [GO:0003725]; mRNA binding [GO:0003729]; protein phosphatase 1 binding [GO:0008157]; RNA binding [GO:0003723]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; messenger ribonucleoprotein complex [GO:1990124]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; double-stranded RNA binding [GO:0003725]; mRNA binding [GO:0003729]; protein phosphatase 1 binding [GO:0008157]; RNA binding [GO:0003723]; anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; cellular response to oxidative stress [GO:0034599]; germ cell development [GO:0007281]; intracellular mRNA localization [GO:0008298]; lncRNA-mediated post-transcriptional gene silencing [GO:0000512]; modification of postsynaptic structure [GO:0099010]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of viral genome replication [GO:0045070]; protein localization to synapse [GO:0035418]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19029303}. Rough endoplasmic reticulum {ECO:0000269|PubMed:19029303}. Note=Localizes exclusively with the rough reticulum endoplasmic (RER).
O95801	reviewed	TTC4_HUMAN	Tetratricopeptide repeat protein 4 (TPR repeat protein 4)	TTC4 My044	Homo sapiens (Human)	387	FUNCTION: May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; protein folding [GO:0006457]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18320024}. Cytoplasm {ECO:0000269|PubMed:29251827}. Note=Predominantly nuclear in the G1 and S phases of cell cycle and is evenly distributed between the nucleus and cytoplasm in the G2 phase (By similarity). MSL1 can promote its nuclear localization (By similarity). {ECO:0000250|UniProtKB:Q8R3H9}.
O95803	reviewed	NDST3_HUMAN	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (Glucosaminyl N-deacetylase/N-sulfotransferase 3) (NDST-3) (hNDST-3) (N-heparan sulfate sulfotransferase 3) (N-HSST 3) [Includes: Heparan sulfate N-deacetylase NDST3 (EC 3.-.-.-); [heparan sulfate]-glucosamine N-sulfotransferase NDST3 (EC 2.8.2.8)]	NDST3 HSST3 UNQ2544/PRO4998	Homo sapiens (Human)	873	FUNCTION: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity. {ECO:0000269|PubMed:9915799}.	MISCELLANEOUS: The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences.	heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	[heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
O95807	reviewed	TM50A_HUMAN	Transmembrane protein 50A (Small membrane protein 1)	TMEM50A SMP1 UNQ386/PRO718	Homo sapiens (Human)	157			late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]	endoplasmic reticulum [GO:0005783]; glial cell projection [GO:0097386]; membrane [GO:0016020]; neuronal cell body [GO:0043025]		endoplasmic reticulum [GO:0005783]; glial cell projection [GO:0097386]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O95810	reviewed	CAVN2_HUMAN	Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein)	CAVIN2 SDPR	Homo sapiens (Human)	425	FUNCTION: Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}.	MISCELLANEOUS: Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.	plasma membrane tubulation [GO:0097320]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	phosphatidylserine binding [GO:0001786]; phospholipid binding [GO:0005543]; protein kinase C binding [GO:0005080]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; phosphatidylserine binding [GO:0001786]; phospholipid binding [GO:0005543]; protein kinase C binding [GO:0005080]; plasma membrane tubulation [GO:0097320]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10191091, ECO:0000269|PubMed:2390065}. Membrane, caveola {ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:19525939}. Note=Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000269|PubMed:19262564}.
O95813	reviewed	CER1_HUMAN	Cerberus (Cerberus-related protein) (DAN domain family member 4)	CER1 DAND4	Homo sapiens (Human)	267	FUNCTION: Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity). {ECO:0000250}.		anterior/posterior axis specification [GO:0009948]; anterior/posterior pattern specification [GO:0009952]; bone mineralization [GO:0030282]; cell migration involved in gastrulation [GO:0042074]; cellular response to cadmium ion [GO:0071276]; determination of dorsal identity [GO:0048263]; determination of heart left/right asymmetry [GO:0061371]; gastrulation [GO:0007369]; growth plate cartilage chondrocyte proliferation [GO:0003419]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mesoderm development [GO:2000381]; negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900176]; nervous system development [GO:0007399]; sequestering of BMP in extracellular matrix [GO:0035582]; signal transduction involved in regulation of gene expression [GO:0023019]; ureteric bud development [GO:0001657]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	BMP binding [GO:0036122]; cytokine activity [GO:0005125]; morphogen activity [GO:0016015]; protein homodimerization activity [GO:0042803]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; BMP binding [GO:0036122]; cytokine activity [GO:0005125]; morphogen activity [GO:0016015]; protein homodimerization activity [GO:0042803]; anterior/posterior axis specification [GO:0009948]; anterior/posterior pattern specification [GO:0009952]; bone mineralization [GO:0030282]; cell migration involved in gastrulation [GO:0042074]; cellular response to cadmium ion [GO:0071276]; determination of dorsal identity [GO:0048263]; determination of heart left/right asymmetry [GO:0061371]; gastrulation [GO:0007369]; growth plate cartilage chondrocyte proliferation [GO:0003419]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mesoderm development [GO:2000381]; negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900176]; nervous system development [GO:0007399]; sequestering of BMP in extracellular matrix [GO:0035582]; signal transduction involved in regulation of gene expression [GO:0023019]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O95816	reviewed	BAG2_HUMAN	BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2)	BAG2	Homo sapiens (Human)	211	FUNCTION: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9873016}.		negative regulation of protein binding [GO:0032091]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein processing [GO:0010954]; protein folding [GO:0006457]; protein metabolic process [GO:0019538]; protein stabilization [GO:0050821]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic microtubule [GO:1901588]; protein folding chaperone complex [GO:0101031]	adenyl-nucleotide exchange factor activity [GO:0000774]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; protein-folding chaperone binding [GO:0051087]; tau protein binding [GO:0048156]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic microtubule [GO:1901588]; protein folding chaperone complex [GO:0101031]; adenyl-nucleotide exchange factor activity [GO:0000774]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; protein-folding chaperone binding [GO:0051087]; tau protein binding [GO:0048156]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; negative regulation of protein binding [GO:0032091]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein processing [GO:0010954]; protein folding [GO:0006457]; protein metabolic process [GO:0019538]; protein stabilization [GO:0050821]	
O95817	reviewed	BAG3_HUMAN	BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)	BAG3 BIS	Homo sapiens (Human)	575	FUNCTION: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:9873016}.		aggresome assembly [GO:0070842]; autophagosome assembly [GO:0000045]; cellular response to heat [GO:0034605]; cellular response to mechanical stimulus [GO:0071260]; cellular response to unfolded protein [GO:0034620]; chaperone-mediated autophagy [GO:0061684]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of apoptotic process [GO:0043066]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; negative regulation of transcription from RNA polymerase II promoter in response to stress [GO:0097201]; positive regulation of aggrephagy [GO:1905337]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; protein transport along microtubule [GO:0098840]; striated muscle cell apoptotic process [GO:0010658]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; stress fiber [GO:0001725]; Z disc [GO:0030018]	adenyl-nucleotide exchange factor activity [GO:0000774]; cadherin binding [GO:0045296]; dynein intermediate chain binding [GO:0045505]; protein carrier chaperone [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; stress fiber [GO:0001725]; Z disc [GO:0030018]; adenyl-nucleotide exchange factor activity [GO:0000774]; cadherin binding [GO:0045296]; dynein intermediate chain binding [GO:0045505]; protein carrier chaperone [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; aggresome assembly [GO:0070842]; autophagosome assembly [GO:0000045]; cellular response to heat [GO:0034605]; cellular response to mechanical stimulus [GO:0071260]; cellular response to unfolded protein [GO:0034620]; chaperone-mediated autophagy [GO:0061684]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of apoptotic process [GO:0043066]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; negative regulation of transcription from RNA polymerase II promoter in response to stress [GO:0097201]; positive regulation of aggrephagy [GO:1905337]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; protein transport along microtubule [GO:0098840]; striated muscle cell apoptotic process [GO:0010658]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26159920}. Cytoplasm {ECO:0000269|PubMed:26159920}. Note=Colocalizes with HSF1 to the nucleus upon heat stress (PubMed:26159920). {ECO:0000269|PubMed:26159920}.
O95819	reviewed	M4K4_HUMAN	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)	MAP4K4 HGK KIAA0687 NIK	Homo sapiens (Human)	1239	FUNCTION: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:9890973}.		intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-matrix adhesion [GO:0001953]; neuron projection morphogenesis [GO:0048812]; positive regulation of ARF protein signal transduction [GO:0032014]; positive regulation of cell migration [GO:0030335]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of GTPase activity [GO:0043547]; positive regulation of keratinocyte migration [GO:0051549]; protein phosphorylation [GO:0006468]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]	ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-matrix adhesion [GO:0001953]; neuron projection morphogenesis [GO:0048812]; positive regulation of ARF protein signal transduction [GO:0032014]; positive regulation of cell migration [GO:0030335]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of GTPase activity [GO:0043547]; positive regulation of keratinocyte migration [GO:0051549]; protein phosphorylation [GO:0006468]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14966141}.
O95822	reviewed	DCMC_HUMAN	Malonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9)	MLYCD	Homo sapiens (Human)	493	FUNCTION: Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. {ECO:0000269|PubMed:10455107, ECO:0000269|PubMed:15003260, ECO:0000269|PubMed:18314420, ECO:0000269|PubMed:23482565}.	MISCELLANEOUS: [Isoform Cytoplasmic+peroxisomal]: May be produced by alternative initiation at Met-40 of isoform mitochondrial. Alternatively, represents a proteolytic processed form of the mitochondrial form. {ECO:0000305}.	acetyl-CoA biosynthetic process [GO:0006085]; acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; fatty acid oxidation [GO:0019395]; malonyl-CoA catabolic process [GO:2001294]; positive regulation of fatty acid oxidation [GO:0046321]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of glucose metabolic process [GO:0010906]; response to ischemia [GO:0002931]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	identical protein binding [GO:0042802]; malonyl-CoA decarboxylase activity [GO:0050080]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; identical protein binding [GO:0042802]; malonyl-CoA decarboxylase activity [GO:0050080]; acetyl-CoA biosynthetic process [GO:0006085]; acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; fatty acid oxidation [GO:0019395]; malonyl-CoA catabolic process [GO:2001294]; positive regulation of fatty acid oxidation [GO:0046321]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of glucose metabolic process [GO:0010906]; response to ischemia [GO:0002931]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10417274}. Mitochondrion matrix {ECO:0000269|PubMed:10417274}. Peroxisome {ECO:0000269|PubMed:10417274}. Peroxisome matrix {ECO:0000250|UniProtKB:Q920F5}. Note=Enzymatically active in all three subcellular compartments. {ECO:0000250|UniProtKB:Q920F5}.
O95831	reviewed	AIFM1_HUMAN	Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8)	AIFM1 AIF PDCD8	Homo sapiens (Human)	613	FUNCTION: Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:20362274, PubMed:23217327, PubMed:17094969, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}.	MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cellular response to aldosterone [GO:1904045]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to nitric oxide [GO:0071732]; cellular response to oxygen-glucose deprivation [GO:0090650]; chromosome condensation [GO:0030261]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mitochondrial respiratory chain complex assembly [GO:0033108]; mitochondrial respiratory chain complex I assembly [GO:0032981]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; positive regulation of apoptotic process [GO:0043065]; positive regulation of necroptotic process [GO:0060545]; positive regulation of neuron apoptotic process [GO:0043525]; protein import into mitochondrial intermembrane space [GO:0045041]; regulation of apoptotic DNA fragmentation [GO:1902510]; response to ischemia [GO:0002931]; response to L-glutamate [GO:1902065]; response to toxic substance [GO:0009636]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	DNA binding [GO:0003677]; FAD binding [GO:0071949]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADH dehydrogenase activity [GO:0003954]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]; poly-ADP-D-ribose binding [GO:0072572]; protein dimerization activity [GO:0046983]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; DNA binding [GO:0003677]; FAD binding [GO:0071949]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADH dehydrogenase activity [GO:0003954]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]; poly-ADP-D-ribose binding [GO:0072572]; protein dimerization activity [GO:0046983]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cellular response to aldosterone [GO:1904045]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to nitric oxide [GO:0071732]; cellular response to oxygen-glucose deprivation [GO:0090650]; chromosome condensation [GO:0030261]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mitochondrial respiratory chain complex assembly [GO:0033108]; mitochondrial respiratory chain complex I assembly [GO:0032981]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; positive regulation of apoptotic process [GO:0043065]; positive regulation of necroptotic process [GO:0060545]; positive regulation of neuron apoptotic process [GO:0043525]; protein import into mitochondrial intermembrane space [GO:0045041]; regulation of apoptotic DNA fragmentation [GO:1902510]; response to ischemia [GO:0002931]; response to L-glutamate [GO:1902065]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:15775970, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:26004228}. Mitochondrion inner membrane. Cytoplasm {ECO:0000269|PubMed:15775970, ECO:0000269|PubMed:33168626}. Nucleus {ECO:0000269|PubMed:15775970, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:33168626}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17094969}. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis (PubMed:15775970). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). Translocation into the nucleus is promoted by interaction with (auto-poly-ADP-ribosylated) processed form of PARP1 (PubMed:33168626). Colocalizes with EIF3G in the nucleus and perinuclear region (PubMed:17094969). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:15775970, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:33168626}.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion intermembrane space {ECO:0000269|PubMed:20111043}. Mitochondrion inner membrane {ECO:0000269|PubMed:20111043}. Note=Has a stronger membrane anchorage than isoform 1. {ECO:0000269|PubMed:20111043}.; SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion {ECO:0000269|PubMed:16644725}. Cytoplasm, cytosol {ECO:0000269|PubMed:16644725}. Note=In pro-apoptotic conditions, is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner. {ECO:0000269|PubMed:16644725}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:16365034}.
O95832	reviewed	CLD1_HUMAN	Claudin-1 (Senescence-associated epithelial membrane protein)	CLDN1 CLD1 SEMP1 UNQ481/PRO944	Homo sapiens (Human)	211	FUNCTION: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). {ECO:0000269|PubMed:23407391}.; FUNCTION: (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes (PubMed:17325668, PubMed:20375010, PubMed:24038151). Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PubMed:20375010). Acts as a receptor for dengue virus (PubMed:24074594). {ECO:0000269|PubMed:17325668, ECO:0000269|PubMed:20375010, ECO:0000269|PubMed:24038151, ECO:0000269|PubMed:24074594}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; cell junction maintenance [GO:0034331]; cell-cell junction organization [GO:0045216]; cellular response to butyrate [GO:1903545]; cellular response to lead ion [GO:0071284]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; establishment of blood-nerve barrier [GO:0008065]; establishment of endothelial intestinal barrier [GO:0090557]; establishment of skin barrier [GO:0061436]; liver regeneration [GO:0097421]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of wound healing [GO:0090303]; protein complex oligomerization [GO:0051259]; response to dexamethasone [GO:0071548]; response to ethanol [GO:0045471]; response to interleukin-18 [GO:0070673]; response to lipopolysaccharide [GO:0032496]; response to toxic substance [GO:0009636]; xenobiotic transport across blood-nerve barrier [GO:0061772]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; virus receptor activity [GO:0001618]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; virus receptor activity [GO:0001618]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; cell junction maintenance [GO:0034331]; cell-cell junction organization [GO:0045216]; cellular response to butyrate [GO:1903545]; cellular response to lead ion [GO:0071284]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; establishment of blood-nerve barrier [GO:0008065]; establishment of endothelial intestinal barrier [GO:0090557]; establishment of skin barrier [GO:0061436]; liver regeneration [GO:0097421]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of wound healing [GO:0090303]; protein complex oligomerization [GO:0051259]; response to dexamethasone [GO:0071548]; response to ethanol [GO:0045471]; response to interleukin-18 [GO:0070673]; response to lipopolysaccharide [GO:0032496]; response to toxic substance [GO:0009636]; xenobiotic transport across blood-nerve barrier [GO:0061772]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:20375010, ECO:0000269|PubMed:23407391}. Cell membrane {ECO:0000269|PubMed:23704991}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:20375010}. Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. {ECO:0000269|PubMed:20375010}.
O95833	reviewed	CLIC3_HUMAN	Chloride intracellular channel protein 3	CLIC3	Homo sapiens (Human)	236	FUNCTION: Can insert into membranes and form chloride ion channels. May participate in cellular growth control. {ECO:0000269|PubMed:9880541}.		chloride transport [GO:0006821]; regulation of monoatomic ion transmembrane transport [GO:0034765]; signal transduction [GO:0007165]	chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleus [GO:0005634]	chloride channel activity [GO:0005254]; voltage-gated monoatomic ion channel activity [GO:0005244]	chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleus [GO:0005634]; chloride channel activity [GO:0005254]; voltage-gated monoatomic ion channel activity [GO:0005244]; chloride transport [GO:0006821]; regulation of monoatomic ion transmembrane transport [GO:0034765]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus. Membrane; Single-pass membrane protein. Cytoplasm. Note=Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250}.
O95834	reviewed	EMAL2_HUMAN	Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2)	EML2 EMAP2 EMAPL2	Homo sapiens (Human)	649	FUNCTION: Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules. {ECO:0000269|PubMed:11694528}.		microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule polymerization [GO:0031115]; regulation of microtubule nucleation [GO:0010968]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; spindle [GO:0005819]	microtubule binding [GO:0008017]; protein self-association [GO:0043621]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; spindle [GO:0005819]; microtubule binding [GO:0008017]; protein self-association [GO:0043621]; tubulin binding [GO:0015631]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule polymerization [GO:0031115]; regulation of microtubule nucleation [GO:0010968]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11694528}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11694528}. Note=Colocalizes with the microtubule cytoskeleton. Colocalizes with the mitotic spindle. {ECO:0000269|PubMed:11694528}.
O95835	reviewed	LATS1_HUMAN	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)	LATS1 WARTS	Homo sapiens (Human)	1130	FUNCTION: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:28068668}.		cell division [GO:0051301]; cytoplasmic sequestering of protein [GO:0051220]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; hippo signaling [GO:0035329]; hormone-mediated signaling pathway [GO:0009755]; inner cell mass cell fate commitment [GO:0001827]; inner cell mass cellular morphogenesis [GO:0001828]; keratinocyte differentiation [GO:0030216]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of apoptotic process [GO:0043065]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein phosphorylation [GO:0006468]; regulation of actin filament polymerization [GO:0030833]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of organ growth [GO:0046620]; regulation of protein-containing complex assembly [GO:0043254]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; sister chromatid segregation [GO:0000819]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; nuclear estrogen receptor binding [GO:0030331]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; nuclear estrogen receptor binding [GO:0030331]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell division [GO:0051301]; cytoplasmic sequestering of protein [GO:0051220]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; hippo signaling [GO:0035329]; hormone-mediated signaling pathway [GO:0009755]; inner cell mass cell fate commitment [GO:0001827]; inner cell mass cellular morphogenesis [GO:0001828]; keratinocyte differentiation [GO:0030216]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of apoptotic process [GO:0043065]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein phosphorylation [GO:0006468]; regulation of actin filament polymerization [GO:0030833]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of organ growth [GO:0046620]; regulation of protein-containing complex assembly [GO:0043254]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; sister chromatid segregation [GO:0000819]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10518011}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10518011}. Midbody {ECO:0000269|PubMed:10518011}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:10518011}. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. {ECO:0000269|PubMed:10518011}.
O95837	reviewed	GNA14_HUMAN	Guanine nucleotide-binding protein subunit alpha-14 (G alpha-14) (G-protein subunit alpha-14)	GNA14	Homo sapiens (Human)	355	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.		action potential [GO:0001508]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; signal transduction [GO:0007165]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; action potential [GO:0001508]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; signal transduction [GO:0007165]	
O95843	reviewed	GUC1C_HUMAN	Guanylyl cyclase-activating protein 3 (GCAP 3) (Guanylate cyclase activator 1C)	GUCA1C GCAP3	Homo sapiens (Human)	209	FUNCTION: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.		signal transduction [GO:0007165]; visual perception [GO:0007601]	photoreceptor disc membrane [GO:0097381]	calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]	photoreceptor disc membrane [GO:0097381]; calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]; signal transduction [GO:0007165]; visual perception [GO:0007601]	
O95847	reviewed	UCP4_HUMAN	Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27)	SLC25A27 UCP4 UNQ772/PRO1566	Homo sapiens (Human)	323	FUNCTION: Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q9D6D0, ECO:0000269|PubMed:10025957, ECO:0000269|PubMed:22524567, ECO:0000269|PubMed:26182433}.		inner ear development [GO:0048839]; intracellular triglyceride homeostasis [GO:0035356]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; regulation of glucose import [GO:0046324]; response to cold [GO:0009409]	apical part of cell [GO:0045177]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]	chloride transmembrane transporter activity [GO:0015108]; protein homodimerization activity [GO:0042803]; proton transmembrane transporter activity [GO:0015078]; transmembrane transporter activity [GO:0022857]	apical part of cell [GO:0045177]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; chloride transmembrane transporter activity [GO:0015108]; protein homodimerization activity [GO:0042803]; proton transmembrane transporter activity [GO:0015078]; transmembrane transporter activity [GO:0022857]; inner ear development [GO:0048839]; intracellular triglyceride homeostasis [GO:0035356]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; regulation of glucose import [GO:0046324]; response to cold [GO:0009409]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:10025957}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to neuronal cell body and processes. Within mitochondrial inner membrane, it is mainly observed in the inner boundary membrane locally separated from F(1)F(0) ATP synthase, which is preferentially localized in cristae. {ECO:0000250|UniProtKB:Q9D6D0}.
O95848	reviewed	NUD14_HUMAN	Uridine diphosphate glucose pyrophosphatase NUDT14 (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 14) (Nudix motif 14)	NUDT14 UGPP	Homo sapiens (Human)	222	FUNCTION: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.		nucleoside phosphate metabolic process [GO:0006753]; protein N-linked glycosylation via asparagine [GO:0018279]; ribose phosphate metabolic process [GO:0019693]	cytosol [GO:0005829]	ADP-ribose diphosphatase activity [GO:0047631]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; UDP-sugar diphosphatase activity [GO:0008768]	cytosol [GO:0005829]; ADP-ribose diphosphatase activity [GO:0047631]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; UDP-sugar diphosphatase activity [GO:0008768]; nucleoside phosphate metabolic process [GO:0006753]; protein N-linked glycosylation via asparagine [GO:0018279]; ribose phosphate metabolic process [GO:0019693]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12429023}.
O95858	reviewed	TSN15_HUMAN	Tetraspanin-15 (Tspan-15) (Tetraspan NET-7) (Transmembrane 4 superfamily member 15)	TSPAN15 NET7 TM4SF15 UNQ677/PRO1311	Homo sapiens (Human)	294	FUNCTION: Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011). Promotes ADAM10-mediated cleavage of CDH2 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862). {ECO:0000250|UniProtKB:F7BWT7, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:30463011}.		negative regulation of Notch signaling pathway [GO:0045746]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]	cell junction [GO:0030054]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197]	enzyme binding [GO:0019899]	cell junction [GO:0030054]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197]; enzyme binding [GO:0019899]; negative regulation of Notch signaling pathway [GO:0045746]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:30463011}; Multi-pass membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:26686862}.
O95859	reviewed	TSN12_HUMAN	Tetraspanin-12 (Tspan-12) (Tetraspan NET-2) (Transmembrane 4 superfamily member 12)	TSPAN12 NET2 TM4SF12 UNQ774/PRO1568	Homo sapiens (Human)	305	FUNCTION: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. {ECO:0000250, ECO:0000269|PubMed:19211836, ECO:0000269|PubMed:19587294}.		angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; maintenance of blood-brain barrier [GO:0035633]; Norrin signaling pathway [GO:0110135]; regulation of angiogenesis [GO:0045765]; retina layer formation [GO:0010842]	membrane [GO:0016020]; plasma membrane [GO:0005886]		membrane [GO:0016020]; plasma membrane [GO:0005886]; angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; maintenance of blood-brain barrier [GO:0035633]; Norrin signaling pathway [GO:0110135]; regulation of angiogenesis [GO:0045765]; retina layer formation [GO:0010842]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
O95861	reviewed	BPNT1_HUMAN	3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (Bisphosphate 3'-nucleotidase 1) (PAP-inositol 1,4-phosphatase) (PIP)	BPNT1	Homo sapiens (Human)	308	FUNCTION: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6. {ECO:0000269|PubMed:10224133}.		3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]	cytosol [GO:0005829]	3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; 3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; metal ion binding [GO:0046872]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]	
O95863	reviewed	SNAI1_HUMAN	Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna)	SNAI1 SNAH	Homo sapiens (Human)	264	FUNCTION: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. {ECO:0000250|UniProtKB:Q02085, ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:23721412}.		aortic valve morphogenesis [GO:0003180]; cartilage morphogenesis [GO:0060536]; epithelial cell migration [GO:0010631]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; hair follicle morphogenesis [GO:0031069]; heterochromatin organization [GO:0070828]; left/right pattern formation [GO:0060972]; mesoderm formation [GO:0001707]; negative regulation of cell differentiation involved in embryonic placenta development [GO:0060806]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D biosynthetic process [GO:0010957]; Notch signaling involved in heart development [GO:0061314]; osteoblast differentiation [GO:0001649]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of DNA-templated transcription [GO:0006355]; roof of mouth development [GO:0060021]; trophoblast giant cell differentiation [GO:0060707]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; aortic valve morphogenesis [GO:0003180]; cartilage morphogenesis [GO:0060536]; epithelial cell migration [GO:0010631]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; hair follicle morphogenesis [GO:0031069]; heterochromatin organization [GO:0070828]; left/right pattern formation [GO:0060972]; mesoderm formation [GO:0001707]; negative regulation of cell differentiation involved in embryonic placenta development [GO:0060806]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D biosynthetic process [GO:0010957]; Notch signaling involved in heart development [GO:0061314]; osteoblast differentiation [GO:0001649]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of DNA-templated transcription [GO:0006355]; roof of mouth development [GO:0060021]; trophoblast giant cell differentiation [GO:0060707]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:24157836, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:25893292}. Cytoplasm {ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15833848}. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs. {ECO:0000269|PubMed:15448698}.
O95864	reviewed	FADS2_HUMAN	Acyl-CoA 6-desaturase (EC 1.14.19.3) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) (Fatty acid desaturase 2)	FADS2	Homo sapiens (Human)	444	FUNCTION: Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:12713571). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). Desaturates hexadecanate (palmitate) to produce 6Z-hexadecenoate (sapienate), a fatty acid unique to humans and major component of human sebum, that has been implicated in the development of acne and may have potent antibacterial activity (PubMed:12713571). It can also desaturate (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity). {ECO:0000250|UniProtKB:B8R1K0, ECO:0000250|UniProtKB:Q9Z122, ECO:0000269|PubMed:12713571}.		alpha-linolenic acid metabolic process [GO:0036109]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; unsaturated fatty acid biosynthetic process [GO:0006636]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	linoleoyl-CoA desaturase activity [GO:0016213]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]; stearoyl-CoA 9-desaturase activity [GO:0004768]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; linoleoyl-CoA desaturase activity [GO:0016213]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]; stearoyl-CoA 9-desaturase activity [GO:0004768]; alpha-linolenic acid metabolic process [GO:0036109]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; unsaturated fatty acid biosynthetic process [GO:0006636]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O95865	reviewed	DDAH2_HUMAN	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (DDAH-2) (Dimethylarginine dimethylaminohydrolase 2) (EC 3.5.3.18) (DDAHII) (Dimethylargininase-2) (Protein G6a) (S-phase protein)	DDAH2 DDAH G6A NG30	Homo sapiens (Human)	285	FUNCTION: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. {ECO:0000269|PubMed:10493931}.		arginine catabolic process [GO:0006527]; arginine metabolic process [GO:0006525]; citrulline metabolic process [GO:0000052]; negative regulation of apoptotic process [GO:0043066]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide metabolic process [GO:0046209]; positive regulation of nitric oxide biosynthetic process [GO:0045429]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	amino acid binding [GO:0016597]; catalytic activity [GO:0003824]; dimethylargininase activity [GO:0016403]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; amino acid binding [GO:0016597]; catalytic activity [GO:0003824]; dimethylargininase activity [GO:0016403]; arginine catabolic process [GO:0006527]; arginine metabolic process [GO:0006525]; citrulline metabolic process [GO:0000052]; negative regulation of apoptotic process [GO:0043066]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide metabolic process [GO:0046209]; positive regulation of nitric oxide biosynthetic process [GO:0045429]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21898353}. Mitochondrion {ECO:0000269|PubMed:21898353}. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes.
O95866	reviewed	G6B_HUMAN	Megakaryocyte and platelet inhibitory receptor G6b (Protein G6b)	MPIG6B C6orf25 G6B G6B-B	Homo sapiens (Human)	241	FUNCTION: Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801). {ECO:0000269|PubMed:12665801, ECO:0000269|PubMed:17311996, ECO:0000269|PubMed:27743390}.; FUNCTION: Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B. {ECO:0000305|PubMed:11544253}.		blood coagulation [GO:0007596]; erythrocyte differentiation [GO:0030218]; integrin-mediated signaling pathway [GO:0007229]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; negative regulation of signal transduction [GO:0009968]; platelet formation [GO:0030220]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	heparin binding [GO:0008201]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; heparin binding [GO:0008201]; blood coagulation [GO:0007596]; erythrocyte differentiation [GO:0030218]; integrin-mediated signaling pathway [GO:0007229]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; negative regulation of signal transduction [GO:0009968]; platelet formation [GO:0030220]	SUBCELLULAR LOCATION: [Isoform E]: Endoplasmic reticulum {ECO:0000269|PubMed:11544253}. Golgi apparatus {ECO:0000269|PubMed:11544253}.; SUBCELLULAR LOCATION: [Isoform D]: Endoplasmic reticulum {ECO:0000269|PubMed:11544253}. Golgi apparatus {ECO:0000269|PubMed:11544253}.; SUBCELLULAR LOCATION: [Isoform B]: Cell membrane {ECO:0000269|PubMed:11544253}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform A]: Cell membrane {ECO:0000269|PubMed:11544253}; Single-pass type I membrane protein {ECO:0000305}.
O95867	reviewed	LY66C_HUMAN	Lymphocyte antigen 6 complex locus protein G6c	LY6G6C C6orf24 G6C NG24 UNQ1947/PRO4430	Homo sapiens (Human)	125				extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; side of membrane [GO:0098552]	identical protein binding [GO:0042802]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; side of membrane [GO:0098552]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17008713}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17008713}.
O95868	reviewed	LY66D_HUMAN	Lymphocyte antigen 6 complex locus protein G6d (Protein Ly6-D) (Megakaryocyte-enhanced gene transcript 1 protein)	LY6G6D C6orf23 G6D MEGT1 NG25	Homo sapiens (Human)	133			acetylcholine receptor signaling pathway [GO:0095500]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; filopodium [GO:0030175]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]	acetylcholine receptor inhibitor activity [GO:0030550]; identical protein binding [GO:0042802]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; filopodium [GO:0030175]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; acetylcholine receptor inhibitor activity [GO:0030550]; identical protein binding [GO:0042802]; acetylcholine receptor signaling pathway [GO:0095500]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17008713}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17008713}. Cell projection, filopodium {ECO:0000269|PubMed:17008713}.
O95870	reviewed	ABHGA_HUMAN	Phosphatidylserine lipase ABHD16A (EC 3.1.-.-) (Alpha/beta hydrolase domain-containing protein 16A) (Abhydrolase domain-containing protein 16A) (HLA-B-associated transcript 5) (hBAT5) (Monoacylglycerol lipase ABHD16A) (EC 3.1.1.23) (Protein G5)	ABHD16A BAT5 G5 NG26 PP199	Homo sapiens (Human)	558	FUNCTION: Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914). {ECO:0000250|UniProtKB:Q9Z1Q2, ECO:0000269|PubMed:25290914}.		monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]; prostaglandin catabolic process [GO:1905344]	membrane [GO:0016020]	acylglycerol lipase activity [GO:0047372]; phospholipase activity [GO:0004620]	membrane [GO:0016020]; acylglycerol lipase activity [GO:0047372]; phospholipase activity [GO:0004620]; monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]; prostaglandin catabolic process [GO:1905344]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9Z1Q2}; Multi-pass membrane protein {ECO:0000255}.
O95872	reviewed	GPAN1_HUMAN	G patch domain and ankyrin repeat-containing protein 1 (Ankyrin repeat domain-containing protein 59) (G patch domain-containing protein 10) (HLA-B-associated transcript 4) (Protein G5)	GPANK1 ANKRD59 BAT4 G5 GPATCH10	Homo sapiens (Human)	356					nucleic acid binding [GO:0003676]	nucleic acid binding [GO:0003676]	
O95876	reviewed	FRITZ_HUMAN	WD repeat-containing and planar cell polarity effector protein fritz homolog (hFRTZ) (Bardet-Biedl syndrome 15 protein) (WD repeat-containing and planar cell polarity effector protein)	WDPCP BBS15 C2orf86 FRITZ	Homo sapiens (Human)	746	FUNCTION: Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). {ECO:0000250|UniProtKB:Q32NR9, ECO:0000250|UniProtKB:Q8C456}.		auditory receptor cell morphogenesis [GO:0002093]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; cilium organization [GO:0044782]; circulatory system development [GO:0072359]; digestive system development [GO:0055123]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; establishment of protein localization [GO:0045184]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; nervous system development [GO:0007399]; neural tube development [GO:0021915]; podocyte cell migration [GO:0090521]; regulation of cilium assembly [GO:1902017]; regulation of embryonic cell shape [GO:0016476]; regulation of establishment of cell polarity [GO:2000114]; regulation of fibroblast migration [GO:0010762]; regulation of focal adhesion assembly [GO:0051893]; regulation of protein localization [GO:0032880]; regulation of ruffle assembly [GO:1900027]; respiratory system development [GO:0060541]; roof of mouth development [GO:0060021]; septin cytoskeleton organization [GO:0032185]; smoothened signaling pathway [GO:0007224]; tongue morphogenesis [GO:0043587]	axonemal basal plate [GO:0097541]; axoneme [GO:0005930]; cilium [GO:0005929]; plasma membrane [GO:0005886]		axonemal basal plate [GO:0097541]; axoneme [GO:0005930]; cilium [GO:0005929]; plasma membrane [GO:0005886]; auditory receptor cell morphogenesis [GO:0002093]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; cilium organization [GO:0044782]; circulatory system development [GO:0072359]; digestive system development [GO:0055123]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; establishment of protein localization [GO:0045184]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; nervous system development [GO:0007399]; neural tube development [GO:0021915]; podocyte cell migration [GO:0090521]; regulation of cilium assembly [GO:1902017]; regulation of embryonic cell shape [GO:0016476]; regulation of establishment of cell polarity [GO:2000114]; regulation of fibroblast migration [GO:0010762]; regulation of focal adhesion assembly [GO:0051893]; regulation of protein localization [GO:0032880]; regulation of ruffle assembly [GO:1900027]; respiratory system development [GO:0060541]; roof of mouth development [GO:0060021]; septin cytoskeleton organization [GO:0032185]; smoothened signaling pathway [GO:0007224]; tongue morphogenesis [GO:0043587]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q32NR9}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q32NR9}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q32NR9}.
O95881	reviewed	TXD12_HUMAN	Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19)	TXNDC12 TLP19 UNQ713/PRO1376	Homo sapiens (Human)	172	FUNCTION: Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity. {ECO:0000269|PubMed:12761212}.		negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	protein-disulfide reductase (glutathione) activity [GO:0019153]; protein-disulfide reductase activity [GO:0015035]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; protein-disulfide reductase (glutathione) activity [GO:0019153]; protein-disulfide reductase activity [GO:0015035]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12761212}.
O95886	reviewed	DLGP3_HUMAN	Disks large-associated protein 3 (DAP-3) (PSD-95/SAP90-binding protein 3) (SAP90/PSD-95-associated protein 3) (SAPAP3)	DLGAP3 DAP3	Homo sapiens (Human)	979	FUNCTION: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.		modification of synaptic structure [GO:0099563]; modulation of chemical synaptic transmission [GO:0050804]; signaling [GO:0023052]	cholinergic synapse [GO:0098981]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572]	amyloid-beta binding [GO:0001540]; molecular adaptor activity [GO:0060090]	cholinergic synapse [GO:0098981]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572]; amyloid-beta binding [GO:0001540]; molecular adaptor activity [GO:0060090]; modification of synaptic structure [GO:0099563]; modulation of chemical synaptic transmission [GO:0050804]; signaling [GO:0023052]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.
O95897	reviewed	NOE2_HUMAN	Noelin-2 (Olfactomedin-2)	OLFM2 NOE2	Homo sapiens (Human)	454	FUNCTION: Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity). {ECO:0000250|UniProtKB:Q568Y7, ECO:0000250|UniProtKB:Q8BM13, ECO:0000269|PubMed:25298399}.		positive regulation of smooth muscle cell differentiation [GO:0051152]; protein secretion [GO:0009306]; regulation of vascular associated smooth muscle cell dedifferentiation [GO:1905174]; signal transduction [GO:0007165]	AMPA glutamate receptor complex [GO:0032281]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]		AMPA glutamate receptor complex [GO:0032281]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]; positive regulation of smooth muscle cell differentiation [GO:0051152]; protein secretion [GO:0009306]; regulation of vascular associated smooth muscle cell dedifferentiation [GO:1905174]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21228389}. Synapse {ECO:0000250|UniProtKB:Q8BM13}. Membrane {ECO:0000250|UniProtKB:Q8BM13}. Nucleus {ECO:0000269|PubMed:25298399}. Cytoplasm {ECO:0000269|PubMed:25298399}. Note=Nuclear localization is induced by TGF-beta. {ECO:0000269|PubMed:25298399}.
O95900	reviewed	TRUB2_HUMAN	Pseudouridylate synthase TRUB2, mitochondrial (EC 5.4.99.-) (TruB pseudouridine synthase homolog 2) (tRNA pseudouridine 55 synthase TRUB2) (Psi55 synthase TRUB2) (EC 5.4.99.25)	TRUB2	Homo sapiens (Human)	331	FUNCTION: Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379, PubMed:31477916). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:33023933). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:33023933}.		mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of mitochondrial translation [GO:0070131]; tRNA processing [GO:0008033]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]	pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of mitochondrial translation [GO:0070131]; tRNA processing [GO:0008033]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:33023933}. Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. {ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677}.
O95905	reviewed	ECD_HUMAN	Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1)	ECD	Homo sapiens (Human)	644	FUNCTION: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). {ECO:0000269|PubMed:16849563, ECO:0000269|PubMed:19640839, ECO:0000269|PubMed:19919181, ECO:0000269|PubMed:23880345, ECO:0000269|PubMed:26711270, ECO:0000305|PubMed:24722212, ECO:0000305|PubMed:9928932}.		fibroblast proliferation [GO:0048144]; mRNA processing [GO:0006397]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone acetyltransferase binding [GO:0035035]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone acetyltransferase binding [GO:0035035]; fibroblast proliferation [GO:0048144]; mRNA processing [GO:0006397]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16849563, ECO:0000269|PubMed:19919181, ECO:0000269|PubMed:26711270}. Nucleus {ECO:0000269|PubMed:16849563, ECO:0000269|PubMed:19919181, ECO:0000269|PubMed:26711270}. Note=Predominantly is located in the cytoplasm. {ECO:0000269|PubMed:16849563, ECO:0000269|PubMed:19919181, ECO:0000269|PubMed:26711270}.
O95907	reviewed	MOT3_HUMAN	Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8)	SLC16A8 MCT3	Homo sapiens (Human)	504	FUNCTION: Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity). {ECO:0000250|UniProtKB:O35308, ECO:0000250|UniProtKB:Q90632}.		lactate transport [GO:0015727]; monocarboxylic acid transport [GO:0015718]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	lactate transmembrane transporter activity [GO:0015129]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; lactate transmembrane transporter activity [GO:0015129]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]; lactate transport [GO:0015727]; monocarboxylic acid transport [GO:0015718]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:21199217}; Multi-pass membrane protein {ECO:0000255}. Note=Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression (PubMed:21199217). Colocalizes with BSG in basolateral cell membrane of the retinal pigment epithelium (By similarity). {ECO:0000250|UniProtKB:O35308, ECO:0000269|PubMed:21199217}.
O95922	reviewed	TTLL1_HUMAN	Polyglutamylase complex subunit TTLL1 (EC 6.3.2.-) (Tubulin polyglutamylase TTLL1) (Tubulin polyglutamylase complex subunit 3) (PGs3) (Tubulin--tyrosine ligase-like protein 1)	TTLL1 C22orf7	Homo sapiens (Human)	423	FUNCTION: Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:34782749). Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step. Modifies both alpha- and beta-tubulins with a preference for the alpha-tail. Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity. Part of the neuronal tubulin polyglutamylase complex. Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. Involved in respiratory motile cilia function through the regulation of beating asymmetry. Essential for sperm flagella biogenesis, motility and male fertility. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. {ECO:0000250|UniProtKB:Q91V51, ECO:0000269|PubMed:34782749}.		cerebellar Purkinje cell differentiation [GO:0021702]; immune response in nasopharyngeal-associated lymphoid tissue [GO:0002395]; microtubule cytoskeleton organization [GO:0000226]; mucociliary clearance [GO:0120197]; protein polyglutamylation [GO:0018095]; regulation of blastocyst development [GO:0120222]; sperm axoneme assembly [GO:0007288]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]; cerebellar Purkinje cell differentiation [GO:0021702]; immune response in nasopharyngeal-associated lymphoid tissue [GO:0002395]; microtubule cytoskeleton organization [GO:0000226]; mucociliary clearance [GO:0120197]; protein polyglutamylation [GO:0018095]; regulation of blastocyst development [GO:0120222]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91V51}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q91V51}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q91V51}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q91V51}.
O95925	reviewed	EPPI_HUMAN	Eppin (Cancer/testis antigen 71) (CT71) (Epididymal protease inhibitor) (Protease inhibitor WAP7) (Serine protease inhibitor-like with Kunitz and WAP domains 1) (WAP four-disulfide core domain protein 7)	EPPIN SPINLW1 WAP7 WFDC7	Homo sapiens (Human)	133	FUNCTION: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. {ECO:0000269|PubMed:15229136, ECO:0000269|PubMed:17644992}.	MISCELLANEOUS: Might be used as a target for male contraception. {ECO:0000305|PubMed:22699487}.; MISCELLANEOUS: [Isoform 2]: Lacks a cleavable signal sequence. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Based on a readthrough transcript which may produce a EPPIN-WFDC6 fusion protein. {ECO:0000305}.	defense response to bacterium [GO:0042742]; negative regulation of calcium ion import [GO:0090281]; negative regulation of flagellated sperm motility [GO:1901318]; negative regulation of peptidase activity [GO:0010466]	acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]; sperm plasma membrane [GO:0097524]	serine-type endopeptidase inhibitor activity [GO:0004867]	acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]; sperm plasma membrane [GO:0097524]; serine-type endopeptidase inhibitor activity [GO:0004867]; defense response to bacterium [GO:0042742]; negative regulation of calcium ion import [GO:0090281]; negative regulation of flagellated sperm motility [GO:1901318]; negative regulation of peptidase activity [GO:0010466]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.
O95926	reviewed	SYF2_HUMAN	Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29)	SYF2 CBPIN GCIPIP	Homo sapiens (Human)	243	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.		embryonic organ development [GO:0048568]; gastrulation [GO:0007369]; in utero embryonic development [GO:0001701]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of cell population proliferation [GO:0008284]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007]; RNA binding [GO:0003723]; embryonic organ development [GO:0048568]; gastrulation [GO:0007369]; in utero embryonic development [GO:0001701]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11118353, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
O95931	reviewed	CBX7_HUMAN	Chromobox protein homolog 7	CBX7	Homo sapiens (Human)	251	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. {ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21047797, ECO:0000269|PubMed:21060834, ECO:0000269|PubMed:21282530}.	MISCELLANEOUS: The human orthologuous proteins of Drosophila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes.	chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]		chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14647293, ECO:0000269|PubMed:21060834, ECO:0000269|PubMed:21282530}.
O95932	reviewed	TGM3L_HUMAN	Protein-glutamine gamma-glutamyltransferase 6 (EC 2.3.2.13) (Transglutaminase Y) (TGY) (TGase Y) (Transglutaminase-3-like) (TGase-3-like) (Transglutaminase-6) (TG6) (TGase-6)	TGM6 TGM3L	Homo sapiens (Human)	706	FUNCTION: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. {ECO:0000250}.			cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23206699, ECO:0000269|PubMed:25253745, ECO:0000269|PubMed:29053796}.
O95935	reviewed	TBX18_HUMAN	T-box transcription factor TBX18 (T-box protein 18)	TBX18	Homo sapiens (Human)	607	FUNCTION: Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area. {ECO:0000250|UniProtKB:Q9EPZ6, ECO:0000269|PubMed:26235987}.		cell fate specification [GO:0001708]; cochlea morphogenesis [GO:0090103]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [GO:0060829]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of SA node cell action potential [GO:0098907]; regulation of transcription by RNA polymerase II [GO:0006357]; sinoatrial node cell development [GO:0060931]; sinoatrial node cell fate commitment [GO:0060930]; sinoatrial node development [GO:0003163]; smooth muscle cell differentiation [GO:0051145]; somitogenesis [GO:0001756]; ureter development [GO:0072189]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cell fate specification [GO:0001708]; cochlea morphogenesis [GO:0090103]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [GO:0060829]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of SA node cell action potential [GO:0098907]; regulation of transcription by RNA polymerase II [GO:0006357]; sinoatrial node cell development [GO:0060931]; sinoatrial node cell fate commitment [GO:0060930]; sinoatrial node development [GO:0003163]; smooth muscle cell differentiation [GO:0051145]; somitogenesis [GO:0001756]; ureter development [GO:0072189]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201, ECO:0000269|PubMed:26235987}.
O95936	reviewed	EOMES_HUMAN	Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2)	EOMES TBR2	Homo sapiens (Human)	686	FUNCTION: Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017}.	MISCELLANEOUS: [Isoform 2]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.	adaptive immune response [GO:0002250]; astrocyte differentiation [GO:0048708]; brain development [GO:0007420]; cardioblast differentiation [GO:0010002]; CD8-positive, alpha-beta T cell differentiation involved in immune response [GO:0002302]; cell differentiation involved in embryonic placenta development [GO:0060706]; cerebral cortex neuron differentiation [GO:0021895]; cerebral cortex regionalization [GO:0021796]; chromatin remodeling [GO:0006338]; DNA demethylation [GO:0080111]; DNA methylation [GO:0006306]; endoderm formation [GO:0001706]; endodermal cell fate specification [GO:0001714]; gene expression [GO:0010467]; mesendoderm development [GO:0048382]; mesoderm formation [GO:0001707]; mesodermal to mesenchymal transition involved in gastrulation [GO:0060809]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; stem cell population maintenance [GO:0019827]; trophectodermal cell differentiation [GO:0001829]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; adaptive immune response [GO:0002250]; astrocyte differentiation [GO:0048708]; brain development [GO:0007420]; cardioblast differentiation [GO:0010002]; CD8-positive, alpha-beta T cell differentiation involved in immune response [GO:0002302]; cell differentiation involved in embryonic placenta development [GO:0060706]; cerebral cortex neuron differentiation [GO:0021895]; cerebral cortex regionalization [GO:0021796]; chromatin remodeling [GO:0006338]; DNA demethylation [GO:0080111]; DNA methylation [GO:0006306]; endoderm formation [GO:0001706]; endodermal cell fate specification [GO:0001714]; gene expression [GO:0010467]; mesendoderm development [GO:0048382]; mesoderm formation [GO:0001707]; mesodermal to mesenchymal transition involved in gastrulation [GO:0060809]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; stem cell population maintenance [GO:0019827]; trophectodermal cell differentiation [GO:0001829]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O95944	reviewed	NCTR2_HUMAN	Natural cytotoxicity triggering receptor 2 (Lymphocyte antigen 95 homolog) (NK cell-activating receptor) (Natural killer cell p44-related protein) (NK-p44) (NKp44) (CD antigen CD336)	NCR2 LY95	Homo sapiens (Human)	276	FUNCTION: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. {ECO:0000269|PubMed:10049942}.		cellular defense response [GO:0006968]; signal transduction [GO:0007165]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; cellular defense response [GO:0006968]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O95947	reviewed	TBX6_HUMAN	T-box transcription factor TBX6 (T-box protein 6)	TBX6	Homo sapiens (Human)	436	FUNCTION: T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; heart looping [GO:0001947]; mesoderm development [GO:0007498]; mesodermal cell fate specification [GO:0007501]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of neuron maturation [GO:0014043]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction involved in regulation of gene expression [GO:0023019]; somite rostral/caudal axis specification [GO:0032525]; vasculogenesis [GO:0001570]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; heart looping [GO:0001947]; mesoderm development [GO:0007498]; mesodermal cell fate specification [GO:0007501]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of neuron maturation [GO:0014043]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction involved in regulation of gene expression [GO:0023019]; somite rostral/caudal axis specification [GO:0032525]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
O95948	reviewed	ONEC2_HUMAN	One cut domain family member 2 (Hepatocyte nuclear factor 6-beta) (HNF-6-beta) (One cut homeobox 2) (Transcription factor ONECUT-2) (OC-2)	ONECUT2 HNF6B	Homo sapiens (Human)	504	FUNCTION: Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.		animal organ morphogenesis [GO:0009887]; cell fate commitment [GO:0045165]; cilium assembly [GO:0060271]; endocrine pancreas development [GO:0031018]; epithelial cell development [GO:0002064]; liver development [GO:0001889]; mesenchymal stem cell migration [GO:1905319]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peripheral nervous system neuron development [GO:0048935]; positive regulation of mesenchymal stem cell migration [GO:1905322]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell-matrix adhesion [GO:0001952]; regulation of transcription by RNA polymerase II [GO:0006357]; transforming growth factor beta receptor signaling pathway [GO:0007179]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ morphogenesis [GO:0009887]; cell fate commitment [GO:0045165]; cilium assembly [GO:0060271]; endocrine pancreas development [GO:0031018]; epithelial cell development [GO:0002064]; liver development [GO:0001889]; mesenchymal stem cell migration [GO:1905319]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peripheral nervous system neuron development [GO:0048935]; positive regulation of mesenchymal stem cell migration [GO:1905322]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell-matrix adhesion [GO:0001952]; regulation of transcription by RNA polymerase II [GO:0006357]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Nucleus.
O95954	reviewed	FTCD_HUMAN	Formimidoyltransferase-cyclodeaminase (Formiminotransferase-cyclodeaminase) (FTCD) (LCHC1) [Includes: Glutamate formimidoyltransferase (EC 2.1.2.5) (Glutamate formiminotransferase) (Glutamate formyltransferase); Formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) (Formiminotetrahydrofolate cyclodeaminase)]	FTCD	Homo sapiens (Human)	541	FUNCTION: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. {ECO:0000269|PubMed:12815595}.; FUNCTION: Binds and promotes bundling of vimentin filaments originating from the Golgi. {ECO:0000250|UniProtKB:O88618}.	MISCELLANEOUS: [Isoform E]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cytoskeleton organization [GO:0007010]; folic acid-containing compound metabolic process [GO:0006760]; histidine catabolic process to glutamate and formamide [GO:0019556]; histidine catabolic process to glutamate and formate [GO:0019557]	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]	folic acid binding [GO:0005542]; formimidoyltetrahydrofolate cyclodeaminase activity [GO:0030412]; glutamate formimidoyltransferase activity [GO:0030409]; microtubule binding [GO:0008017]	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; folic acid binding [GO:0005542]; formimidoyltetrahydrofolate cyclodeaminase activity [GO:0030412]; glutamate formimidoyltransferase activity [GO:0030409]; microtubule binding [GO:0008017]; cytoskeleton organization [GO:0007010]; folic acid-containing compound metabolic process [GO:0006760]; histidine catabolic process to glutamate and formamide [GO:0019556]; histidine catabolic process to glutamate and formate [GO:0019557]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9YH58}. Golgi apparatus {ECO:0000250|UniProtKB:Q9YH58}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:16534631}. Note=More abundantly located around the mother centriole. {ECO:0000269|PubMed:16534631}.
O95967	reviewed	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1)	EFEMP2 FBLN4 UNQ200/PRO226	Homo sapiens (Human)	443	FUNCTION: Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta (PubMed:27339457). In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin (By similarity). Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction (PubMed:18973305, PubMed:19570982). Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling (PubMed:23782690). {ECO:0000250|UniProtKB:Q9WVJ9, ECO:0000269|PubMed:18973305, ECO:0000269|PubMed:19570982, ECO:0000269|PubMed:23782690, ECO:0000269|PubMed:27339457}.		aorta development [GO:0035904]; aorta smooth muscle tissue morphogenesis [GO:0060414]; elastic fiber assembly [GO:0048251]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of aortic smooth muscle cell differentiation [GO:1904831]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of smooth muscle cell-matrix adhesion [GO:1905609]; regulation of collagen fibril organization [GO:1904026]; vascular associated smooth muscle cell development [GO:0097084]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; microfibril [GO:0001527]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; microfibril [GO:0001527]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]; aorta development [GO:0035904]; aorta smooth muscle tissue morphogenesis [GO:0060414]; elastic fiber assembly [GO:0048251]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of aortic smooth muscle cell differentiation [GO:1904831]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of smooth muscle cell-matrix adhesion [GO:1905609]; regulation of collagen fibril organization [GO:1904026]; vascular associated smooth muscle cell development [GO:0097084]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20389311, ECO:0000269|PubMed:27339457}. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:Q9WVJ9}. Note=Localizes on the microfibrils surrounding ELN cores. {ECO:0000250|UniProtKB:Q9WVJ9}.
O95968	reviewed	SG1D1_HUMAN	Secretoglobin family 1D member 1 (Lipophilin-A)	SCGB1D1 LIPHA LPNA	Homo sapiens (Human)	90	FUNCTION: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.			extracellular space [GO:0005615]		extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O95970	reviewed	LGI1_HUMAN	Leucine-rich glioma-inactivated protein 1 (Epitempin-1)	LGI1 EPT UNQ775/PRO1569	Homo sapiens (Human)	557	FUNCTION: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. {ECO:0000250, ECO:0000269|PubMed:15047712, ECO:0000269|PubMed:16518856}.		axon guidance [GO:0007411]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of cell growth [GO:0030307]; positive regulation of synaptic transmission [GO:0050806]	axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; synaptic cleft [GO:0043083]	signaling receptor binding [GO:0005102]	axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; synaptic cleft [GO:0043083]; signaling receptor binding [GO:0005102]; axon guidance [GO:0007411]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of cell growth [GO:0030307]; positive regulation of synaptic transmission [GO:0050806]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16787412, ECO:0000269|PubMed:17067999, ECO:0000269|PubMed:17296837}. Synapse {ECO:0000250|UniProtKB:Q8K4Y5}. Cytoplasm {ECO:0000250|UniProtKB:Q9JIA1}.; SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus {ECO:0000269|PubMed:17067999}. Secreted {ECO:0000269|PubMed:9879993}. Cytoplasm {ECO:0000250|UniProtKB:Q9JIA1}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum {ECO:0000269|PubMed:17067999}. Cytoplasm {ECO:0000250|UniProtKB:Q9JIA1}.
O95971	reviewed	BY55_HUMAN	CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]	CD160 BY55	Homo sapiens (Human)	181	FUNCTION: [CD160 antigen]: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:19109136, PubMed:11978774, PubMed:17307798). Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372, PubMed:12486241). In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241). On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144). On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity). {ECO:0000250|UniProtKB:O88875, ECO:0000269|PubMed:11978774, ECO:0000269|PubMed:12486241, ECO:0000269|PubMed:16809620, ECO:0000269|PubMed:17307798, ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:19109136, ECO:0000269|PubMed:25255144, ECO:0000269|PubMed:9973372}.; FUNCTION: [CD160 antigen, soluble form]: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions. {ECO:0000269|PubMed:17237375}.	MISCELLANEOUS: [Isoform 3]: Mutagenesis of Tyr-225 to Phe abolishes intracellular signaling. {ECO:0000269|PubMed:19109136}.	adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; mucosal immune response [GO:0002385]; negative regulation of adaptive immune memory response [GO:1905675]; negative regulation of angiogenesis [GO:0016525]; negative regulation of CD4-positive, alpha-beta T cell costimulation [GO:1900280]; negative regulation of T cell receptor signaling pathway [GO:0050860]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated immune response to tumor cell [GO:0002857]; positive regulation of type II interferon production [GO:0032729]; T cell costimulation [GO:0031295]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	activating MHC class I receptor activity [GO:0032397]; kinase binding [GO:0019900]; MHC class I protein complex binding [GO:0023024]; MHC class I receptor activity [GO:0032393]; MHC class Ib receptor activity [GO:0032394]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; activating MHC class I receptor activity [GO:0032397]; kinase binding [GO:0019900]; MHC class I protein complex binding [GO:0023024]; MHC class I receptor activity [GO:0032393]; MHC class Ib receptor activity [GO:0032394]; signaling receptor binding [GO:0005102]; adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; mucosal immune response [GO:0002385]; negative regulation of adaptive immune memory response [GO:1905675]; negative regulation of angiogenesis [GO:0016525]; negative regulation of CD4-positive, alpha-beta T cell costimulation [GO:1900280]; negative regulation of T cell receptor signaling pathway [GO:0050860]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated immune response to tumor cell [GO:0002857]; positive regulation of type II interferon production [GO:0032729]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: [CD160 antigen]: Cell membrane {ECO:0000269|PubMed:12486241, ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:9973372}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:23761635, ECO:0000269|PubMed:9743336}.; SUBCELLULAR LOCATION: [CD160 antigen, soluble form]: Secreted. Note=Released from the cell membrane by GPI cleavage. {ECO:0000269|PubMed:17237375, ECO:0000269|PubMed:23761635, ECO:0000269|PubMed:9743336}.
O95972	reviewed	BMP15_HUMAN	Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B)	BMP15 GDF9B	Homo sapiens (Human)	392	FUNCTION: May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. {ECO:0000269|PubMed:18227435}.	MISCELLANEOUS: The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa).; MISCELLANEOUS: Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.	female gamete generation [GO:0007292]	endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]	endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; female gamete generation [GO:0007292]	SUBCELLULAR LOCATION: Secreted.
O95977	reviewed	S1PR4_HUMAN	Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6)	S1PR4 EDG6	Homo sapiens (Human)	384	FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. {ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}.		activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of metabolic process [GO:0019222]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; sphingosine-1-phosphate receptor activity [GO:0038036]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; sphingosine-1-phosphate receptor activity [GO:0038036]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of metabolic process [GO:0019222]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O95980	reviewed	RECK_HUMAN	Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein)	RECK ST15	Homo sapiens (Human)	971	FUNCTION: Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:9789069, PubMed:18194466). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069). {ECO:0000250|UniProtKB:Q9Z0J1, ECO:0000269|PubMed:18194466, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314, ECO:0000269|PubMed:9789069}.		blood vessel maturation [GO:0001955]; canonical Wnt signaling pathway [GO:0060070]; embryo implantation [GO:0007566]; embryonic forelimb morphogenesis [GO:0035115]; extracellular matrix organization [GO:0030198]; negative regulation of cell migration [GO:0030336]; negative regulation of metalloendopeptidase activity [GO:1904684]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of angiogenesis [GO:0045765]; regulation of establishment of blood-brain barrier [GO:0090210]; sprouting angiogenesis [GO:0002040]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; Wnt signalosome [GO:1990909]	coreceptor activity [GO:0015026]; endopeptidase inhibitor activity [GO:0004866]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867]; Wnt-protein binding [GO:0017147]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; Wnt signalosome [GO:1990909]; coreceptor activity [GO:0015026]; endopeptidase inhibitor activity [GO:0004866]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867]; Wnt-protein binding [GO:0017147]; blood vessel maturation [GO:0001955]; canonical Wnt signaling pathway [GO:0060070]; embryo implantation [GO:0007566]; embryonic forelimb morphogenesis [GO:0035115]; extracellular matrix organization [GO:0030198]; negative regulation of cell migration [GO:0030336]; negative regulation of metalloendopeptidase activity [GO:1904684]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of angiogenesis [GO:0045765]; regulation of establishment of blood-brain barrier [GO:0090210]; sprouting angiogenesis [GO:0002040]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30026314, ECO:0000269|PubMed:9789069}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:9789069}.
O95983	reviewed	MBD3_HUMAN	Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3)	MBD3	Homo sapiens (Human)	291	FUNCTION: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}.		chromatin remodeling [GO:0006338]; DNA methylation-dependent heterochromatin formation [GO:0006346]; embryonic organ development [GO:0048568]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of DNA methylation [GO:0044030]; regulation of stem cell differentiation [GO:2000736]; response to estradiol [GO:0032355]; response to nutrient levels [GO:0031667]; tissue development [GO:0009888]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; methyl-CpG binding [GO:0008327]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; methyl-CpG binding [GO:0008327]; chromatin remodeling [GO:0006338]; DNA methylation-dependent heterochromatin formation [GO:0006346]; embryonic organ development [GO:0048568]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of DNA methylation [GO:0044030]; regulation of stem cell differentiation [GO:2000736]; response to estradiol [GO:0032355]; response to nutrient levels [GO:0031667]; tissue development [GO:0009888]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15701600, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Chromosome {ECO:0000269|PubMed:27732854}. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes. {ECO:0000269|PubMed:27732854}.
O95985	reviewed	TOP3B_HUMAN	DNA topoisomerase 3-beta-1 (EC 5.6.2.1) (DNA topoisomerase III beta-1)	TOP3B TOP3B1	Homo sapiens (Human)	862	FUNCTION: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity. {ECO:0000250}.		chromosome segregation [GO:0007059]; DNA topological change [GO:0006265]	condensed chromosome [GO:0000793]; DNA topoisomerase III-beta-TDRD3 complex [GO:0140225]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA topoisomerase activity [GO:0003916]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; RNA binding [GO:0003723]	condensed chromosome [GO:0000793]; DNA topoisomerase III-beta-TDRD3 complex [GO:0140225]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA topoisomerase activity [GO:0003916]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; RNA binding [GO:0003723]; chromosome segregation [GO:0007059]; DNA topological change [GO:0006265]	
O95988	reviewed	TCL1B_HUMAN	T-cell leukemia/lymphoma protein 1B (Oncogene TCL-1B) (Oncogene TCL1B) (SYN-1) (Syncytiotrophoblast-specific protein) (TCL1/MTCP1-like protein 1)	TCL1B TCL1	Homo sapiens (Human)	128	FUNCTION: Enhances the phosphorylation and activation of AKT1 and AKT2. {ECO:0000269|PubMed:10983986}.	MISCELLANEOUS: Activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region.	positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein serine/threonine kinase activity [GO:0071902]	protein-containing complex [GO:0032991]	protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]	protein-containing complex [GO:0032991]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein serine/threonine kinase activity [GO:0071902]	
O95989	reviewed	NUDT3_HUMAN	Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mRNA hydrolase) (EC 3.6.1.62) (m7GpppX diphosphatase) (EC 3.6.1.59)	NUDT3 DIPP DIPP1	Homo sapiens (Human)	172	FUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:12370170, PubMed:9822604, PubMed:10585413). InsP6 (inositol hexakisphosphate) is not a substrate (PubMed:9822604). Acts as a negative regulator of the ERK1/2 pathway (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates (PubMed:12370170, PubMed:10419486). The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A (PubMed:12370170). Also able to hydrolyze 5-phosphoribose 1-diphosphate (PubMed:12370170). Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility (PubMed:26932476). Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA (PubMed:32727897). Can hydrolyze unmethylated capped RNAs (By similarity). Divalent cations zinc, magnesium and manganese determine its substrate specificity (PubMed:34788624). Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions, diadenosine hexaphosphate hydrolase activity in the presence of manganese ions and endopolyphosphatase activity in the presence of zinc ions (PubMed:34788624). Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity (PubMed:34788624). {ECO:0000250|UniProtKB:Q9JI46, ECO:0000269|PubMed:10419486, ECO:0000269|PubMed:10585413, ECO:0000269|PubMed:12370170, ECO:0000269|PubMed:34788624, ECO:0000269|PubMed:9822604, ECO:0000305|PubMed:26932476}.		adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; cell-cell signaling [GO:0007267]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diadenosine polyphosphate catabolic process [GO:0015961]; diphosphoinositol polyphosphate catabolic process [GO:0071544]; diphosphoinositol polyphosphate metabolic process [GO:0071543]; RNA decapping [GO:0110154]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity [GO:0140932]; 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842]; inositol diphosphate tetrakisphosphate diphosphatase activity [GO:0052840]; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [GO:0052848]; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [GO:0052845]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity [GO:0140932]; 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842]; inositol diphosphate tetrakisphosphate diphosphatase activity [GO:0052840]; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [GO:0052848]; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [GO:0052845]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; zinc ion binding [GO:0008270]; adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; cell-cell signaling [GO:0007267]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diadenosine polyphosphate catabolic process [GO:0015961]; diphosphoinositol polyphosphate catabolic process [GO:0071544]; diphosphoinositol polyphosphate metabolic process [GO:0071543]; RNA decapping [GO:0110154]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34788624}. Nucleus {ECO:0000269|PubMed:34788624}.
O95990	reviewed	F107A_HUMAN	Actin-associated protein FAM107A (Down-regulated in renal cell carcinoma 1) (Protein TU3A)	FAM107A DRR1 TU3A	Homo sapiens (Human)	144	FUNCTION: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741). May play a role in tumor development (PubMed:10564580). {ECO:0000250|UniProtKB:Q78TU8, ECO:0000269|PubMed:10564580, ECO:0000269|PubMed:20543869, ECO:0000269|PubMed:28604741}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	actin filament bundle assembly [GO:0051017]; actin filament polymerization [GO:0030041]; cell cycle [GO:0007049]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to nutrient levels [GO:0031669]; cognition [GO:0050890]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of long-term synaptic potentiation [GO:1900272]; positive regulation of cell migration [GO:0030335]; positive regulation of protein ubiquitination [GO:0031398]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell growth [GO:0001558]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of protein stability [GO:0031647]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; stress fiber [GO:0001725]; synapse [GO:0045202]	actin binding [GO:0003779]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; stress fiber [GO:0001725]; synapse [GO:0045202]; actin binding [GO:0003779]; actin filament bundle assembly [GO:0051017]; actin filament polymerization [GO:0030041]; cell cycle [GO:0007049]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to nutrient levels [GO:0031669]; cognition [GO:0050890]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of long-term synaptic potentiation [GO:1900272]; positive regulation of cell migration [GO:0030335]; positive regulation of protein ubiquitination [GO:0031398]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell growth [GO:0001558]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10564580, ECO:0000269|PubMed:11256614, ECO:0000269|PubMed:20543869, ECO:0000269|PubMed:28604741}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:20543869, ECO:0000269|PubMed:28604741}. Cell junction, focal adhesion {ECO:0000269|PubMed:20543869}. Cell projection, ruffle membrane {ECO:0000269|PubMed:20543869}. Synapse {ECO:0000250|UniProtKB:Q78TU8}. Note=Colocalizes with F-actin and COMMD1 in the nucleus (PubMed:28604741). Colocalizes with MAP1A along actin stress fibers and membrane ruffles (PubMed:20543869). {ECO:0000269|PubMed:20543869, ECO:0000269|PubMed:28604741}.
O95992	reviewed	CH25H_HUMAN	Cholesterol 25-hydroxylase (EC 1.14.99.38) (Cholesterol 25-monooxygenase) (h25OH)	CH25H	Homo sapiens (Human)	272	FUNCTION: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity). May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing (PubMed:9852097). As an interferon-stimulated gene, has broad antiviral activities against a wide range of enveloped viruses, such as vesicular stomatitis virus (VSV) and SARS coronavirus-2 (SARS-CoV-2). Its product, 25-hydroxycholesterol, activates the ER-localized enzyme ACAT to induce internalization of accessible cholesterol on the plasma membrane and restricts SARS-CoV-2 S protein-mediated fusion which inhibits virus replication (PubMed:33239446, PubMed:32944968). In testis, production of 25-hydroxycholesterol by macrophages plays a role in Leydig cell differentiation (By similarity). Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (By similarity). {ECO:0000250|UniProtKB:Q4QQV7, ECO:0000250|UniProtKB:Q9Z0F5, ECO:0000269|PubMed:32944968, ECO:0000269|PubMed:33239446, ECO:0000269|PubMed:9852097}.		B cell chemotaxis [GO:0035754]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol metabolic process [GO:0090206]; negative regulation of fusion of virus membrane with host plasma membrane [GO:1903914]; response to type I interferon [GO:0034340]; sterol biosynthetic process [GO:0016126]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]	C-4 methylsterol oxidase activity [GO:0000254]; cholesterol 25-hydroxylase activity [GO:0001567]; iron ion binding [GO:0005506]; steroid hydroxylase activity [GO:0008395]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; C-4 methylsterol oxidase activity [GO:0000254]; cholesterol 25-hydroxylase activity [GO:0001567]; iron ion binding [GO:0005506]; steroid hydroxylase activity [GO:0008395]; B cell chemotaxis [GO:0035754]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol metabolic process [GO:0090206]; negative regulation of fusion of virus membrane with host plasma membrane [GO:1903914]; response to type I interferon [GO:0034340]; sterol biosynthetic process [GO:0016126]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z0F5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Z0F5}.
O95994	reviewed	AGR2_HUMAN	Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog)	AGR2 AG2 UNQ515/PRO1030	Homo sapiens (Human)	175	FUNCTION: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). {ECO:0000250, ECO:0000269|PubMed:18199544, ECO:0000269|PubMed:23274113}.		digestive tract morphogenesis [GO:0048546]; inflammatory response [GO:0006954]; lung goblet cell differentiation [GO:0060480]; mucus secretion [GO:0070254]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of developmental growth [GO:0048639]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of gene expression [GO:0010628]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; positive regulation of protein localization to plasma membrane [GO:1903078]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	dystroglycan binding [GO:0002162]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; dystroglycan binding [GO:0002162]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; digestive tract morphogenesis [GO:0048546]; inflammatory response [GO:0006954]; lung goblet cell differentiation [GO:0060480]; mucus secretion [GO:0070254]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of developmental growth [GO:0048639]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of gene expression [GO:0010628]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; positive regulation of protein localization to plasma membrane [GO:1903078]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15834940}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O88312}.
O95995	reviewed	DRC4_HUMAN	Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8)	GAS8 DRC4 GAS11	Homo sapiens (Human)	478	FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning (PubMed:26387594, PubMed:27120127, PubMed:27472056). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q60779, ECO:0000250|UniProtKB:Q7XJ96, ECO:0000269|PubMed:26387594, ECO:0000269|PubMed:27120127, ECO:0000269|PubMed:27472056}.		axoneme assembly [GO:0035082]; brain development [GO:0007420]; cilium movement involved in cell motility [GO:0060294]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization [GO:0008104]; regulation of microtubule binding [GO:1904526]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]	microtubule binding [GO:0008017]; small GTPase binding [GO:0031267]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267]; axoneme assembly [GO:0035082]; brain development [GO:0007420]; cilium movement involved in cell motility [GO:0060294]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization [GO:0008104]; regulation of microtubule binding [GO:1904526]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q60779}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10969087}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q60779}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:16643277, ECO:0000269|PubMed:26387594}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q60779}. Golgi apparatus {ECO:0000269|PubMed:16643277}. Cell projection, cilium {ECO:0000269|PubMed:27120127}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q7XJ96}. Note=Associates with microtubules (PubMed:10969087). Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa (By similarity). {ECO:0000250|UniProtKB:Q60779, ECO:0000269|PubMed:10969087}.
O95996	reviewed	APCL_HUMAN	Adenomatous polyposis coli protein 2 (Adenomatous polyposis coli protein-like) (APC-like)	APC2 APCL	Homo sapiens (Human)	2303	FUNCTION: Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329). {ECO:0000269|PubMed:10021369, ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:25753423, ECO:0000269|PubMed:9823329}.		activation of GTPase activity [GO:0090630]; cell fate specification [GO:0001708]; cell migration [GO:0016477]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; pattern specification process [GO:0007389]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell differentiation [GO:0045595]; Wnt signaling pathway [GO:0016055]	actin filament [GO:0005884]; beta-catenin destruction complex [GO:0030877]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intercellular bridge [GO:0045171]; lamellipodium membrane [GO:0031258]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]	beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; microtubule binding [GO:0008017]	actin filament [GO:0005884]; beta-catenin destruction complex [GO:0030877]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intercellular bridge [GO:0045171]; lamellipodium membrane [GO:0031258]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; microtubule binding [GO:0008017]; activation of GTPase activity [GO:0090630]; cell fate specification [GO:0001708]; cell migration [GO:0016477]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; pattern specification process [GO:0007389]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell differentiation [GO:0045595]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10644998, ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:25753423}. Golgi apparatus {ECO:0000269|PubMed:11691822}. Cytoplasm {ECO:0000269|PubMed:11691822}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10646860}. Note=Associated with actin filaments (PubMed:11691822, PubMed:25753423). Associated with microtubule network (PubMed:10644998, PubMed:11691822, PubMed:25753423). {ECO:0000269|PubMed:10644998, ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:25753423}.
O95997	reviewed	PTTG1_HUMAN	Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG)	PTTG1 EAP1 PTTG TUTR1	Homo sapiens (Human)	202	FUNCTION: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11238996, ECO:0000269|PubMed:11371342, ECO:0000269|PubMed:12355087}.		cell division [GO:0051301]; chromosome organization [GO:0051276]; DNA repair [GO:0006281]; homologous chromosome segregation [GO:0045143]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; molecular function activator activity [GO:0140677]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; molecular function activator activity [GO:0140677]; SH3 domain binding [GO:0017124]; cell division [GO:0051301]; chromosome organization [GO:0051276]; DNA repair [GO:0006281]; homologous chromosome segregation [GO:0045143]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
O95998	reviewed	I18BP_HUMAN	Interleukin-18-binding protein (IL-18BP) (Tadekinig-alfa)	IL18BP	Homo sapiens (Human)	194	FUNCTION: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. {ECO:0000269|PubMed:10023777, ECO:0000269|PubMed:10655506, ECO:0000269|PubMed:31213488}.		cellular response to hydrogen peroxide [GO:0070301]; cellular response to tumor necrosis factor [GO:0071356]; response to lipopolysaccharide [GO:0032496]; T-helper 1 type immune response [GO:0042088]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	interleukin-18 binding [GO:0042007]; receptor antagonist activity [GO:0048019]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-18 binding [GO:0042007]; receptor antagonist activity [GO:0048019]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to tumor necrosis factor [GO:0071356]; response to lipopolysaccharide [GO:0032496]; T-helper 1 type immune response [GO:0042088]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31213488}.
O95999	reviewed	BCL10_HUMAN	B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10)	BCL10 CIPER CLAP	Homo sapiens (Human)	233	FUNCTION: Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:25365219, PubMed:24074955). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:27777308, PubMed:24074955). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:27777308, PubMed:24074955). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). {ECO:0000269|PubMed:10187770, ECO:0000269|PubMed:10187815, ECO:0000269|PubMed:10364242, ECO:0000269|PubMed:10400625, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:25365219, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:27777308}.		adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; B cell apoptotic process [GO:0001783]; canonical NF-kappaB signal transduction [GO:0007249]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of mature B cell apoptotic process [GO:0002906]; neural tube closure [GO:0001843]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lymphotoxin A production [GO:0032761]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell receptor signaling pathway [GO:0050862]; programmed cell death [GO:0012501]; protein homooligomerization [GO:0051260]; response to food [GO:0032094]; T cell apoptotic process [GO:0070231]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor signaling pathway [GO:0002224]	CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; lysosome [GO:0005764]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polkadots [GO:0002096]; protein-containing complex [GO:0032991]	CARD domain binding [GO:0050700]; general transcription initiation factor binding [GO:0140296]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; protease binding [GO:0002020]; protein kinase B binding [GO:0043422]; protein self-association [GO:0043621]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]	CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; lysosome [GO:0005764]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polkadots [GO:0002096]; protein-containing complex [GO:0032991]; CARD domain binding [GO:0050700]; general transcription initiation factor binding [GO:0140296]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; protease binding [GO:0002020]; protein kinase B binding [GO:0043422]; protein self-association [GO:0043621]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]; adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; B cell apoptotic process [GO:0001783]; canonical NF-kappaB signal transduction [GO:0007249]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of mature B cell apoptotic process [GO:0002906]; neural tube closure [GO:0001843]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lymphotoxin A production [GO:0032761]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell receptor signaling pathway [GO:0050862]; programmed cell death [GO:0012501]; protein homooligomerization [GO:0051260]; response to food [GO:0032094]; T cell apoptotic process [GO:0070231]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor signaling pathway [GO:0002224]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17287217}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:17287217}.
O96000	reviewed	NDUBA_HUMAN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (Complex I-PDSW) (CI-PDSW) (NADH-ubiquinone oxidoreductase PDSW subunit)	NDUFB10	Homo sapiens (Human)	172	FUNCTION: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain. {ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:28040730}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:28040730, ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
O96004	reviewed	HAND1_HUMAN	Heart- and neural crest derivatives-expressed protein 1 (Class A basic helix-loop-helix protein 27) (bHLHa27) (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND)	HAND1 BHLHA27 EHAND	Homo sapiens (Human)	215	FUNCTION: Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (PubMed:9931445). {ECO:0000250|UniProtKB:Q64279, ECO:0000269|PubMed:9931445}.		angiogenesis [GO:0001525]; blastocyst development [GO:0001824]; cardiac left ventricle formation [GO:0003218]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cartilage morphogenesis [GO:0060536]; embryonic heart tube development [GO:0035050]; embryonic heart tube formation [GO:0003144]; heart development [GO:0007507]; heart looping [GO:0001947]; mesenchyme development [GO:0060485]; mesoderm formation [GO:0001707]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; trophectodermal cell differentiation [GO:0001829]; trophoblast giant cell differentiation [GO:0060707]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coregulator binding [GO:0001221]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coregulator binding [GO:0001221]; angiogenesis [GO:0001525]; blastocyst development [GO:0001824]; cardiac left ventricle formation [GO:0003218]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cartilage morphogenesis [GO:0060536]; embryonic heart tube development [GO:0035050]; embryonic heart tube formation [GO:0003144]; heart development [GO:0007507]; heart looping [GO:0001947]; mesenchyme development [GO:0060485]; mesoderm formation [GO:0001707]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; trophectodermal cell differentiation [GO:0001829]; trophoblast giant cell differentiation [GO:0060707]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). {ECO:0000250}.
O96005	reviewed	CLPT1_HUMAN	Putative lipid scramblase CLPTM1 (Cleft lip and palate transmembrane protein 1)	CLPTM1	Homo sapiens (Human)	669	FUNCTION: Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate (By similarity). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (PubMed:29255114). May play a role in T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8VBZ3, ECO:0000250|UniProtKB:Q96KA5, ECO:0000269|PubMed:29255114}.		cell differentiation [GO:0030154]; regulation of T cell differentiation in thymus [GO:0033081]	endomembrane system [GO:0012505]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GABA receptor binding [GO:0050811]	endomembrane system [GO:0012505]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; GABA receptor binding [GO:0050811]; cell differentiation [GO:0030154]; regulation of T cell differentiation in thymus [GO:0033081]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
O96006	reviewed	ZBED1_HUMAN	E3 SUMO-protein ligase ZBED1 (EC 2.3.2.-) (DNA replication-related element-binding factor) (Putative Ac-like transposable element) (Zinc finger BED domain-containing protein 1) (dREF homolog)	ZBED1 ALTE DREF hDREF KIAA0785 TRAMP	Homo sapiens (Human)	694	FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747). This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). The resulting increased transcriptional activity drives cell proliferation (PubMed:12663651, PubMed:17220279). Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). {ECO:0000269|PubMed:12663651, ECO:0000269|PubMed:17209048, ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:27068747}.; FUNCTION: (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection. {ECO:0000269|PubMed:25210186}.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.	negative regulation by host of viral genome replication [GO:0044828]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autosumoylation [GO:1990466]; protein sumoylation [GO:0016925]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	centrosome [GO:0005813]; chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	centrosome [GO:0005813]; chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; negative regulation by host of viral genome replication [GO:0044828]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autosumoylation [GO:1990466]; protein sumoylation [GO:0016925]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000269|PubMed:25210186, ECO:0000269|PubMed:27068747}. Nucleus {ECO:0000269|PubMed:12663651, ECO:0000269|PubMed:17209048}. Note=In granular structures. {ECO:0000269|PubMed:12663651, ECO:0000269|PubMed:17209048}.; SUBCELLULAR LOCATION: Nucleus, PML body. Note=(Microbial infection) Upon interaction with human adenovirus early E1A protein, the protein is redistributed to the peripheral areas of PML bodies. {ECO:0000269|PubMed:25210186}.
O96007	reviewed	MOC2B_HUMAN	Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (MOCO1-B) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B) (Molybdopterin-synthase large subunit) (MPT synthase large subunit)	MOCS2 MCBPE MOCO1	Homo sapiens (Human)	188	FUNCTION: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. {ECO:0000255|HAMAP-Rule:MF_03052, ECO:0000269|PubMed:12732628, ECO:0000269|PubMed:15073332}.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame. Expression of these 2 proteins are related since a mutation that removes the start codon of the small subunit (MOCS2A) also impairs expression of the large subunit (MOCS2B).	Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor biosynthetic process [GO:0032324]	cytosol [GO:0005829]; molybdopterin synthase complex [GO:0019008]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	molybdopterin synthase activity [GO:0030366]	cytosol [GO:0005829]; molybdopterin synthase complex [GO:0019008]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; molybdopterin synthase activity [GO:0030366]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor biosynthetic process [GO:0032324]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03052, ECO:0000269|PubMed:15073332}.
O96008	reviewed	TOM40_HUMAN	Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5)	TOMM40 C19orf1 PEREC1 TOM40	Homo sapiens (Human)	361	FUNCTION: Channel-forming protein essential for import of protein precursors into mitochondria (PubMed:15644312, PubMed:31206022). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (PubMed:31206022). {ECO:0000269|PubMed:15644312, ECO:0000269|PubMed:31206022}.		monoatomic ion transport [GO:0006811]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; pore complex [GO:0046930]	porin activity [GO:0015288]; protein transmembrane transporter activity [GO:0008320]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; pore complex [GO:0046930]; porin activity [GO:0015288]; protein transmembrane transporter activity [GO:0008320]; monoatomic ion transport [GO:0006811]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:15644312, ECO:0000269|PubMed:31206022}; Multi-pass membrane protein {ECO:0000255}. Note=Associates with the mitochondria-associated ER membrane via interaction with BCAP31. {ECO:0000269|PubMed:31206022}.
O96009	reviewed	NAPSA_HUMAN	Napsin-A (EC 3.4.23.-) (Aspartyl protease 4) (ASP4) (Asp 4) (Napsin-1) (TA01/TA02)	NAPSA NAP1 NAPA	Homo sapiens (Human)	420	FUNCTION: May be involved in processing of pneumocyte surfactant precursors.		membrane protein proteolysis [GO:0033619]; proteolysis [GO:0006508]; surfactant homeostasis [GO:0043129]	alveolar lamellar body [GO:0097208]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosome [GO:0005764]; multivesicular body lumen [GO:0097486]	aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]	alveolar lamellar body [GO:0097208]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosome [GO:0005764]; multivesicular body lumen [GO:0097486]; aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; membrane protein proteolysis [GO:0033619]; proteolysis [GO:0006508]; surfactant homeostasis [GO:0043129]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O96011	reviewed	PX11B_HUMAN	Peroxisomal membrane protein 11B (Peroxin-11B) (Peroxisomal biogenesis factor 11B) (Protein PEX11 homolog beta) (PEX11-beta)	PEX11B	Homo sapiens (Human)	259	FUNCTION: Involved in peroxisomal proliferation (PubMed:9792670). May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455). {ECO:0000269|PubMed:12618434, ECO:0000269|PubMed:20826455, ECO:0000269|PubMed:9792670}.		peroxisome fission [GO:0016559]; peroxisome organization [GO:0007031]; regulation of peroxisome size [GO:0044375]; signal transduction [GO:0007165]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; peroxisome fission [GO:0016559]; peroxisome organization [GO:0007031]; regulation of peroxisome size [GO:0044375]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:20826455, ECO:0000269|PubMed:9792670, ECO:0000269|PubMed:9826565}; Single-pass membrane protein {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:9792670, ECO:0000269|PubMed:9826565}.
O96013	reviewed	PAK4_HUMAN	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)	PAK4 KIAA1142	Homo sapiens (Human)	591	FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26607847}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell migration [GO:0016477]; cellular response to organic cyclic compound [GO:0071407]; cytoskeleton organization [GO:0007010]; dendritic spine development [GO:0060996]; intracellular signal transduction [GO:0035556]; negative regulation of endothelial cell apoptotic process [GO:2000352]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; regulation of cell growth [GO:0001558]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]	ATP binding [GO:0005524]; cadherin binding involved in cell-cell adhesion [GO:0098641]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; ATP binding [GO:0005524]; cadherin binding involved in cell-cell adhesion [GO:0098641]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell migration [GO:0016477]; cellular response to organic cyclic compound [GO:0071407]; cytoskeleton organization [GO:0007010]; dendritic spine development [GO:0060996]; intracellular signal transduction [GO:0035556]; negative regulation of endothelial cell apoptotic process [GO:2000352]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; regulation of cell growth [GO:0001558]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12356872}. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. {ECO:0000269|PubMed:12356872}.
O96014	reviewed	WNT11_HUMAN	Protein Wnt-11	WNT11	Homo sapiens (Human)	354	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.		adrenal gland development [GO:0030325]; artery morphogenesis [GO:0048844]; atrial septum development [GO:0003283]; bicellular tight junction assembly [GO:0070830]; bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to mechanical stimulus [GO:0071260]; cellular response to retinoic acid [GO:0071300]; cloacal septation [GO:0060197]; convergent extension involved in axis elongation [GO:0060028]; embryonic skeletal system development [GO:0048706]; epithelial cell apoptotic process [GO:1904019]; epithelial to mesenchymal transition [GO:0001837]; lung-associated mesenchyme development [GO:0060484]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesenchymal cell proliferation [GO:0010463]; mesonephric duct development [GO:0072177]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of stem cell proliferation [GO:2000647]; neuroendocrine cell differentiation [GO:0061101]; neuron differentiation [GO:0030182]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; paraxial mesoderm formation [GO:0048341]; planar cell polarity pathway involved in axis elongation [GO:0003402]; planar cell polarity pathway involved in gastrula mediolateral intercalation [GO:0060775]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of GTPase activity [GO:0043547]; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [GO:0090082]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transforming growth factor beta2 production [GO:0032915]; primary heart field specification [GO:0003138]; protein localization to cell surface [GO:0034394]; protein phosphorylation [GO:0006468]; response to nutrient levels [GO:0031667]; secondary heart field specification [GO:0003139]; secondary palate development [GO:0062009]; signal transduction [GO:0007165]; somite development [GO:0061053]; stem cell proliferation [GO:0072089]; ureteric bud morphogenesis [GO:0060675]; ventricular septum morphogenesis [GO:0060412]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; GTPase activator activity [GO:0005096]; protein kinase activator activity [GO:0030295]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; GTPase activator activity [GO:0005096]; protein kinase activator activity [GO:0030295]; adrenal gland development [GO:0030325]; artery morphogenesis [GO:0048844]; atrial septum development [GO:0003283]; bicellular tight junction assembly [GO:0070830]; bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to mechanical stimulus [GO:0071260]; cellular response to retinoic acid [GO:0071300]; cloacal septation [GO:0060197]; convergent extension involved in axis elongation [GO:0060028]; embryonic skeletal system development [GO:0048706]; epithelial cell apoptotic process [GO:1904019]; epithelial to mesenchymal transition [GO:0001837]; lung-associated mesenchyme development [GO:0060484]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesenchymal cell proliferation [GO:0010463]; mesonephric duct development [GO:0072177]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of stem cell proliferation [GO:2000647]; neuroendocrine cell differentiation [GO:0061101]; neuron differentiation [GO:0030182]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; paraxial mesoderm formation [GO:0048341]; planar cell polarity pathway involved in axis elongation [GO:0003402]; planar cell polarity pathway involved in gastrula mediolateral intercalation [GO:0060775]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of GTPase activity [GO:0043547]; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [GO:0090082]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transforming growth factor beta2 production [GO:0032915]; primary heart field specification [GO:0003138]; protein localization to cell surface [GO:0034394]; protein phosphorylation [GO:0006468]; response to nutrient levels [GO:0031667]; secondary heart field specification [GO:0003139]; secondary palate development [GO:0062009]; signal transduction [GO:0007165]; somite development [GO:0061053]; stem cell proliferation [GO:0072089]; ureteric bud morphogenesis [GO:0060675]; ventricular septum morphogenesis [GO:0060412]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
O96015	reviewed	DNAL4_HUMAN	Dynein axonemal light chain 4	DNAL4	Homo sapiens (Human)	105	FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity). {ECO:0000250}.		microtubule-based movement [GO:0007018]	cilium [GO:0005929]; cytoplasm [GO:0005737]; dynein complex [GO:0030286]; microtubule [GO:0005874]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; microtubule motor activity [GO:0003777]	cilium [GO:0005929]; cytoplasm [GO:0005737]; dynein complex [GO:0030286]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}.
O96017	reviewed	CHK2_HUMAN	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)	CHEK2 CDS1 CHK2 RAD53	Homo sapiens (Human)	543	FUNCTION: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}.	MISCELLANEOUS: [Isoform 2]: Lacks enzymatic activity. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Lacks enzymatic activity. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Lacks enzymatic activity. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Retains low level of catalytic activity. {ECO:0000305}.; MISCELLANEOUS: [Isoform 10]: Lacks enzymatic activity. {ECO:0000305}.; MISCELLANEOUS: [Isoform 12]: Lacks enzymatic activity. {ECO:0000305}.	cell division [GO:0051301]; cellular response to gamma radiation [GO:0071480]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic DNA damage checkpoint signaling [GO:0044773]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; mitotic spindle assembly [GO:0090307]; positive regulation of DNA-templated transcription [GO:0045893]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein catabolic process [GO:0042176]; regulation of signal transduction by p53 class mediator [GO:1901796]; replicative senescence [GO:0090399]; signal transduction in response to DNA damage [GO:0042770]; thymocyte apoptotic process [GO:0070242]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase binding [GO:0031625]; cell division [GO:0051301]; cellular response to gamma radiation [GO:0071480]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic DNA damage checkpoint signaling [GO:0044773]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; mitotic spindle assembly [GO:0090307]; positive regulation of DNA-templated transcription [GO:0045893]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein catabolic process [GO:0042176]; regulation of signal transduction by p53 class mediator [GO:1901796]; replicative senescence [GO:0090399]; signal transduction in response to DNA damage [GO:0042770]; thymocyte apoptotic process [GO:0070242]	SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Note=Isoform 10 is present throughout the cell.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 7]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 9]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 12]: Nucleus.; SUBCELLULAR LOCATION: Nucleus, PML body. Nucleus, nucleoplasm. Note=Recruited into PML bodies together with TP53.
O96018	reviewed	APBA3_HUMAN	Amyloid-beta A4 precursor protein-binding family A member 3 (Adapter protein X11gamma) (Neuron-specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3)	APBA3 MINT3 X11L2	Homo sapiens (Human)	575	FUNCTION: May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. {ECO:0000269|PubMed:19726677}.		chemical synaptic transmission [GO:0007268]; in utero embryonic development [GO:0001701]; negative regulation of catalytic activity [GO:0043086]; protein transport [GO:0015031]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	amyloid-beta binding [GO:0001540]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]	cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; amyloid-beta binding [GO:0001540]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; chemical synaptic transmission [GO:0007268]; in utero embryonic development [GO:0001701]; negative regulation of catalytic activity [GO:0043086]; protein transport [GO:0015031]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:19726677}.
O96019	reviewed	ACL6A_HUMAN	Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K)	ACTL6A BAF53 BAF53A INO80K	Homo sapiens (Human)	429	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250|UniProtKB:Q9Z2N8, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:15196461, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.		blastocyst formation [GO:0001825]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; negative regulation of cell differentiation [GO:0045596]; nervous system development [GO:0007399]; neural retina development [GO:0003407]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; telomere maintenance [GO:0000723]	brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; Ino80 complex [GO:0031011]; kinetochore [GO:0000776]; npBAF complex [GO:0071564]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	chromatin binding [GO:0003682]; transcription coactivator activity [GO:0003713]	brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; Ino80 complex [GO:0031011]; kinetochore [GO:0000776]; npBAF complex [GO:0071564]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; chromatin binding [GO:0003682]; transcription coactivator activity [GO:0003713]; blastocyst formation [GO:0001825]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; negative regulation of cell differentiation [GO:0045596]; nervous system development [GO:0007399]; neural retina development [GO:0003407]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18026119}.
O96020	reviewed	CCNE2_HUMAN	G1/S-specific cyclin-E2	CCNE2	Homo sapiens (Human)	404	FUNCTION: Essential for the control of the cell cycle at the late G1 and early S phase.		cell division [GO:0051301]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; homologous chromosome pairing at meiosis [GO:0007129]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of protein localization [GO:0032880]; telomere maintenance [GO:0000723]	centrosome [GO:0005813]; cyclin E1-CDK2 complex [GO:0097134]; cyclin E2-CDK2 complex [GO:0097135]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901]	centrosome [GO:0005813]; cyclin E1-CDK2 complex [GO:0097134]; cyclin E2-CDK2 complex [GO:0097135]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901]; cell division [GO:0051301]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; homologous chromosome pairing at meiosis [GO:0007129]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of protein localization [GO:0032880]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9840943}.
O96024	reviewed	B3GT4_HUMAN	Beta-1,3-galactosyltransferase 4 (Beta-1,3-GalTase 4) (Beta3Gal-T4) (Beta3GalT4) (GalT4) (b3Gal-T4) (EC 2.4.1.62) (Gal-T2) (Ganglioside galactosyltransferase) (UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase)	B3GALT4 GALT4	Homo sapiens (Human)	378	FUNCTION: Involved in GM1/GD1B/GA1 ganglioside biosynthesis. {ECO:0000269|PubMed:9582303}.		ganglioside biosynthetic process [GO:0001574]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	ganglioside galactosyltransferase activity [GO:0047915]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; ganglioside galactosyltransferase activity [GO:0047915]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; ganglioside biosynthetic process [GO:0001574]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Z0F0}; Single-pass type II membrane protein {ECO:0000255}.
O96028	reviewed	NSD2_HUMAN	Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)	NSD2 KIAA1090 MMSET TRX5 WHSC1	Homo sapiens (Human)	1365	FUNCTION: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:27571355, PubMed:22099308, PubMed:19808676, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}.		atrial septum primum morphogenesis [GO:0003289]; atrial septum secundum morphogenesis [GO:0003290]; bone development [GO:0060348]; double-strand break repair [GO:0006302]; membranous septum morphogenesis [GO:0003149]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of establishment of protein localization [GO:0070201]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H4K20 methyltransferase activity [GO:0042799]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H4K20 methyltransferase activity [GO:0042799]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; atrial septum primum morphogenesis [GO:0003289]; atrial septum secundum morphogenesis [GO:0003290]; bone development [GO:0060348]; double-strand break repair [GO:0006302]; membranous septum morphogenesis [GO:0003149]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of establishment of protein localization [GO:0070201]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15677557, ECO:0000269|PubMed:16197452}. Chromosome {ECO:0000250|UniProtKB:Q8BVE8}. Note=In embryonic stem (ES) cells, localizes to small foci, probably corresponding to euchromatin (By similarity). In B-cells, localizes to Ig heavy chain switch region during class switch recombination (By similarity). {ECO:0000250|UniProtKB:Q8BVE8}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:15677557, ECO:0000269|PubMed:16197452}. Chromosome {ECO:0000269|PubMed:15677557}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:15677557, ECO:0000269|PubMed:16197452}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:15677557, ECO:0000269|PubMed:16197452}. Nucleus, nucleolus {ECO:0000269|PubMed:15677557, ECO:0000269|PubMed:16197452}.
O96033	reviewed	MOC2A_HUMAN	Molybdopterin synthase sulfur carrier subunit (MOCO1-A) (Molybdenum cofactor synthesis protein 2 small subunit) (Molybdenum cofactor synthesis protein 2A) (MOCS2A) (Molybdopterin-synthase small subunit) (Sulfur carrier protein MOCS2A)	MOCS2 MOCO1	Homo sapiens (Human)	88	FUNCTION: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. {ECO:0000255|HAMAP-Rule:MF_03051, ECO:0000269|PubMed:12732628}.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B) from an overlapping reading frame. Expression of these 2 proteins are related since a mutation that removes the start codon of the small subunit (MOCS2A) also impairs expression of the large subunit (MOCS2B).	Mo-molybdopterin cofactor biosynthetic process [GO:0006777]	cytosol [GO:0005829]; molybdopterin synthase complex [GO:0019008]	molybdopterin synthase activity [GO:0030366]; nucleotide binding [GO:0000166]	cytosol [GO:0005829]; molybdopterin synthase complex [GO:0019008]; molybdopterin synthase activity [GO:0030366]; nucleotide binding [GO:0000166]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03051, ECO:0000269|PubMed:15073332}.
O97980	reviewed	HMHB1_HUMAN	Minor histocompatibility protein HB-1 [Cleaved into: Minor histocompatibility antigen HB-1 (mHag HB-1)]	HMHB1	Homo sapiens (Human)	41	FUNCTION: Precursor of the histocomplatibility antigen HB-1. More generally, minor histocomplatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocomplatibility antigen in HLA-matched sibling marrow transplants. HB-1 is presented on the cell surface by MHC class I HLA-B44. This complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity in B-cell acute lymphoblastic leukemia (B-ALL) after treatment by HLA-identical allogenic bone marrow transplantation (BMT). It induces cell recognition and lysis by CTL. However, HB-1 restricted expression in B-ALL cells and not in normal tissues may allow a specific CTL reactivity against B-ALL without the risk of evoking graft-versus-host disease. {ECO:0000269|PubMed:15102363, ECO:0000269|PubMed:8992968, ECO:0000269|PubMed:9892612}.		adaptive immune response [GO:0002250]; cellular response to tumor necrosis factor [GO:0071356]; positive regulation of type II interferon production [GO:0032729]; regulation of gene expression [GO:0010468]			adaptive immune response [GO:0002250]; cellular response to tumor necrosis factor [GO:0071356]; positive regulation of type II interferon production [GO:0032729]; regulation of gene expression [GO:0010468]	
P00156	reviewed	CYB_HUMAN	Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit)	MT-CYB COB CYTB MTCYB	Homo sapiens (Human)	380	FUNCTION: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. {ECO:0000250|UniProtKB:P00157}.	MISCELLANEOUS: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm. {ECO:0000250}.	cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]	metal ion binding [GO:0046872]; ubiquinol-cytochrome-c reductase activity [GO:0008121]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00157}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00157}.
P00167	reviewed	CYB5_HUMAN	Cytochrome b5 (Microsomal cytochrome b5 type A) (MCB5)	CYB5A CYB5	Homo sapiens (Human)	134	FUNCTION: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]	cytochrome-c oxidase activity [GO:0004129]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; cytochrome-c oxidase activity [GO:0004129]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
P00325	reviewed	ADH1B_HUMAN	All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta)	ADH1B ADH2	Homo sapiens (Human)	375	FUNCTION: Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387). Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820). {ECO:0000269|PubMed:15369820, ECO:0000269|PubMed:16787387}.	MISCELLANEOUS: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.	ethanol oxidation [GO:0006069]; retinoic acid metabolic process [GO:0042573]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; NAD-retinol dehydrogenase activity [GO:0004745]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; NAD-retinol dehydrogenase activity [GO:0004745]; zinc ion binding [GO:0008270]; ethanol oxidation [GO:0006069]; retinoic acid metabolic process [GO:0042573]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]	SUBCELLULAR LOCATION: Cytoplasm.
P00326	reviewed	ADH1G_HUMAN	Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase subunit gamma)	ADH1C ADH3	Homo sapiens (Human)	375	FUNCTION: Alcohol dehydrogenase. Exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. {ECO:0000269|PubMed:6391957}.	MISCELLANEOUS: There are 7 different ADH's isozymes in human: three belongs to class-I: ADH1A, ADH1B, and ADH1C, one to class-II: ADH4, one to class-III: ADH5, one to class-IV: ADH7 and one to class-V: ADH6.	ethanol oxidation [GO:0006069]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	alcohol dehydrogenase (NAD+) activity [GO:0004022]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; NAD-retinol dehydrogenase activity [GO:0004745]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; alcohol dehydrogenase (NAD+) activity [GO:0004022]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; NAD-retinol dehydrogenase activity [GO:0004745]; zinc ion binding [GO:0008270]; ethanol oxidation [GO:0006069]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]	SUBCELLULAR LOCATION: Cytoplasm.
P00338	reviewed	LDHA_HUMAN	L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)	LDHA PIG19	Homo sapiens (Human)	332	FUNCTION: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}.		glycolytic process [GO:0006096]; lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090]; substantia nigra development [GO:0021762]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; L-lactate dehydrogenase activity [GO:0004459]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; L-lactate dehydrogenase activity [GO:0004459]; glycolytic process [GO:0006096]; lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasm.
P00352	reviewed	AL1A1_HUMAN	Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1)	ALDH1A1 ALDC ALDH1 PUMB1	Homo sapiens (Human)	501	FUNCTION: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:19296407, PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:26373694, PubMed:25450233). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:19296407, PubMed:12941160, PubMed:15623782). Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). {ECO:0000250|UniProtKB:P24549, ECO:0000269|PubMed:12941160, ECO:0000269|PubMed:15623782, ECO:0000269|PubMed:17175089, ECO:0000269|PubMed:19296407, ECO:0000269|PubMed:25450233, ECO:0000269|PubMed:26373694}.		cellular aldehyde metabolic process [GO:0006081]; cellular detoxification of aldehyde [GO:0110095]; fructosamine catabolic process [GO:0030392]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; maintenance of lens transparency [GO:0036438]; negative regulation of cold-induced thermogenesis [GO:0120163]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; synapse [GO:0045202]	3-deoxyglucosone dehydrogenase activity [GO:0106373]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aminobutyraldehyde dehydrogenase activity [GO:0019145]; androgen binding [GO:0005497]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; GTPase activator activity [GO:0005096]; NAD binding [GO:0051287]; retinal dehydrogenase activity [GO:0001758]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; synapse [GO:0045202]; 3-deoxyglucosone dehydrogenase activity [GO:0106373]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aminobutyraldehyde dehydrogenase activity [GO:0019145]; androgen binding [GO:0005497]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; GTPase activator activity [GO:0005096]; NAD binding [GO:0051287]; retinal dehydrogenase activity [GO:0001758]; cellular aldehyde metabolic process [GO:0006081]; cellular detoxification of aldehyde [GO:0110095]; fructosamine catabolic process [GO:0030392]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; maintenance of lens transparency [GO:0036438]; negative regulation of cold-induced thermogenesis [GO:0120163]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12941160}. Cell projection, axon {ECO:0000250|UniProtKB:P24549}.
P00367	reviewed	DHE3_HUMAN	Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)	GLUD1 GLUD	Homo sapiens (Human)	558	FUNCTION: Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:16959573, PubMed:11254391, PubMed:16023112). Plays a role in insulin homeostasis (PubMed:9571255, PubMed:11297618). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). {ECO:0000250|UniProtKB:P10860, ECO:0000269|PubMed:11032875, ECO:0000269|PubMed:11254391, ECO:0000269|PubMed:11297618, ECO:0000269|PubMed:16023112, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:9571255}.		glutamate biosynthetic process [GO:0006537]; glutamate catabolic process [GO:0006538]; glutamine metabolic process [GO:0006541]; positive regulation of insulin secretion [GO:0032024]; substantia nigra development [GO:0021762]; tricarboxylic acid metabolic process [GO:0072350]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; glutamate dehydrogenase (NAD+) activity [GO:0004352]; glutamate dehydrogenase (NADP+) activity [GO:0004354]; glutamate dehydrogenase [NAD(P)+] activity [GO:0004353]; GTP binding [GO:0005525]; leucine binding [GO:0070728]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; glutamate dehydrogenase (NAD+) activity [GO:0004352]; glutamate dehydrogenase (NADP+) activity [GO:0004354]; glutamate dehydrogenase [NAD(P)+] activity [GO:0004353]; GTP binding [GO:0005525]; leucine binding [GO:0070728]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]; glutamate biosynthetic process [GO:0006537]; glutamate catabolic process [GO:0006538]; glutamine metabolic process [GO:0006541]; positive regulation of insulin secretion [GO:0032024]; substantia nigra development [GO:0021762]; tricarboxylic acid metabolic process [GO:0072350]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19448744}. Endoplasmic reticulum {ECO:0000269|PubMed:19448744}. Note=Mostly translocates into the mitochondria, only a small amount of the protein localizes to the endoplasmic reticulum. {ECO:0000269|PubMed:19448744}.
P00374	reviewed	DYR_HUMAN	Dihydrofolate reductase (EC 1.5.1.3)	DHFR	Homo sapiens (Human)	187	FUNCTION: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. {ECO:0000269|PubMed:12096917, ECO:0000269|PubMed:21876188}.		axon regeneration [GO:0031103]; dihydrofolate metabolic process [GO:0046452]; folic acid metabolic process [GO:0046655]; glycine biosynthetic process [GO:0006545]; negative regulation of translation [GO:0017148]; one-carbon metabolic process [GO:0006730]; positive regulation of nitric-oxide synthase activity [GO:0051000]; regulation of removal of superoxide radicals [GO:2000121]; response to methotrexate [GO:0031427]; tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654]; tetrahydrofolate metabolic process [GO:0046653]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	dihydrofolate reductase activity [GO:0004146]; folic acid binding [GO:0005542]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; NADP binding [GO:0050661]; NADPH binding [GO:0070402]; sequence-specific mRNA binding [GO:1990825]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; dihydrofolate reductase activity [GO:0004146]; folic acid binding [GO:0005542]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; NADP binding [GO:0050661]; NADPH binding [GO:0070402]; sequence-specific mRNA binding [GO:1990825]; axon regeneration [GO:0031103]; dihydrofolate metabolic process [GO:0046452]; folic acid metabolic process [GO:0046655]; glycine biosynthetic process [GO:0006545]; negative regulation of translation [GO:0017148]; one-carbon metabolic process [GO:0006730]; positive regulation of nitric-oxide synthase activity [GO:0051000]; regulation of removal of superoxide radicals [GO:2000121]; response to methotrexate [GO:0031427]; tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654]; tetrahydrofolate metabolic process [GO:0046653]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P00375}. Cytoplasm {ECO:0000250|UniProtKB:P00375}.
P00387	reviewed	NB5R3_HUMAN	NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC 1.6.2.2) (Diaphorase-1)	CYB5R3 DIA1	Homo sapiens (Human)	301	FUNCTION: Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor. {ECO:0000269|PubMed:10807796, ECO:0000269|PubMed:1400360, ECO:0000269|PubMed:15953014, ECO:0000269|PubMed:1898726, ECO:0000269|PubMed:2019583, ECO:0000269|PubMed:8119939, ECO:0000269|PubMed:9639531}.		blood circulation [GO:0008015]; cholesterol biosynthetic process [GO:0006695]; nitric oxide biosynthetic process [GO:0006809]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; hemoglobin complex [GO:0005833]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nitric-oxide synthase complex [GO:1903958]	ADP binding [GO:0043531]; AMP binding [GO:0016208]; cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; FAD binding [GO:0071949]; NAD binding [GO:0051287]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; hemoglobin complex [GO:0005833]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nitric-oxide synthase complex [GO:1903958]; ADP binding [GO:0043531]; AMP binding [GO:0016208]; cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; FAD binding [GO:0071949]; NAD binding [GO:0051287]; blood circulation [GO:0008015]; cholesterol biosynthetic process [GO:0006695]; nitric oxide biosynthetic process [GO:0006809]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9639531}; Lipid-anchor {ECO:0000250|UniProtKB:P20070}; Cytoplasmic side {ECO:0000250|UniProtKB:P20070}. Mitochondrion outer membrane {ECO:0000305|PubMed:9639531}; Lipid-anchor {ECO:0000250|UniProtKB:P20070}; Cytoplasmic side {ECO:0000250|UniProtKB:P20070}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:9639531}.
P00390	reviewed	GSHR_HUMAN	Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7)	GSR GLUR GRD1	Homo sapiens (Human)	522	FUNCTION: Maintains high levels of reduced glutathione in the cytosol.	MISCELLANEOUS: The active site is a redox-active disulfide bond.; MISCELLANEOUS: [Isoform Cytoplasmic]: Produced by alternative initiation of isoform Mitochondrial. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Expressed at very high levels in peripheral blood. {ECO:0000305}.	cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glutathione metabolic process [GO:0006749]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; glutathione-disulfide reductase (NADP) activity [GO:0004362]; NADP binding [GO:0050661]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; glutathione-disulfide reductase (NADP) activity [GO:0004362]; NADP binding [GO:0050661]; cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glutathione metabolic process [GO:0006749]	SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm.
P00395	reviewed	COX1_HUMAN	Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide I)	MT-CO1 COI COXI MTCO1	Homo sapiens (Human)	513	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00401}.		cellular respiration [GO:0045333]; cerebellum development [GO:0021549]; electron transport coupled proton transport [GO:0015990]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; response to copper ion [GO:0046688]; response to electrical stimulus [GO:0051602]; response to oxidative stress [GO:0006979]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrial respiratory chain complex IV [GO:0005751]; respiratory chain complex IV [GO:0045277]	cytochrome-c oxidase activity [GO:0004129]; heme binding [GO:0020037]; metal ion binding [GO:0046872]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrial respiratory chain complex IV [GO:0005751]; respiratory chain complex IV [GO:0045277]; cytochrome-c oxidase activity [GO:0004129]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; cellular respiration [GO:0045333]; cerebellum development [GO:0021549]; electron transport coupled proton transport [GO:0015990]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; response to copper ion [GO:0046688]; response to electrical stimulus [GO:0051602]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Multi-pass membrane protein {ECO:0000269|PubMed:30030519}.
P00403	reviewed	COX2_HUMAN	Cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide II)	MT-CO2 COII COX2 COXII MTCO2	Homo sapiens (Human)	227	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00410}.		ATP synthesis coupled electron transport [GO:0042773]; cellular respiration [GO:0045333]; lactation [GO:0007595]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]	copper ion binding [GO:0005507]; cytochrome-c oxidase activity [GO:0004129]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]; copper ion binding [GO:0005507]; cytochrome-c oxidase activity [GO:0004129]; ATP synthesis coupled electron transport [GO:0042773]; cellular respiration [GO:0045333]; lactation [GO:0007595]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Multi-pass membrane protein {ECO:0000269|PubMed:30030519}.
P00414	reviewed	COX3_HUMAN	Cytochrome c oxidase subunit 3 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide III)	MT-CO3 COIII COXIII MTCO3	Homo sapiens (Human)	261	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00420}.		cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; respiratory chain complex IV assembly [GO:0008535]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; respiratory chain complex IV [GO:0045277]	cytochrome-c oxidase activity [GO:0004129]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; respiratory chain complex IV [GO:0045277]; cytochrome-c oxidase activity [GO:0004129]; cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; respiratory chain complex IV assembly [GO:0008535]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Multi-pass membrane protein {ECO:0000269|PubMed:30030519}.
P00439	reviewed	PH4H_HUMAN	Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase)	PAH	Homo sapiens (Human)	452	FUNCTION: Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. {ECO:0000269|PubMed:18460651, ECO:0000269|PubMed:18835579}.		amino acid biosynthetic process [GO:0008652]; catecholamine biosynthetic process [GO:0042423]; L-phenylalanine catabolic process [GO:0006559]; neurotransmitter biosynthetic process [GO:0042136]; tyrosine biosynthetic process [GO:0006571]	cytosol [GO:0005829]	iron ion binding [GO:0005506]; phenylalanine 4-monooxygenase activity [GO:0004505]	cytosol [GO:0005829]; iron ion binding [GO:0005506]; phenylalanine 4-monooxygenase activity [GO:0004505]; amino acid biosynthetic process [GO:0008652]; catecholamine biosynthetic process [GO:0042423]; L-phenylalanine catabolic process [GO:0006559]; neurotransmitter biosynthetic process [GO:0042136]; tyrosine biosynthetic process [GO:0006571]	
P00441	reviewed	SODC_HUMAN	Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1)	SOD1	Homo sapiens (Human)	154	FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:24140062}.	MISCELLANEOUS: The protein (both wild-type and ALS1 variants) has a tendency to form fibrillar aggregates in the absence of the intramolecular disulfide bond or of bound zinc ions. These aggregates may have cytotoxic effects. Zinc binding promotes dimerization and stabilizes the native form.	action potential initiation [GO:0099610]; anterograde axonal transport [GO:0008089]; apoptotic process [GO:0006915]; auditory receptor cell stereocilium organization [GO:0060088]; determination of adult lifespan [GO:0008340]; ectopic germ cell programmed cell death [GO:0035234]; embryo implantation [GO:0007566]; gene expression [GO:0010467]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide biosynthetic process [GO:0050665]; intracellular iron ion homeostasis [GO:0006879]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; myeloid cell homeostasis [GO:0002262]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of developmental process [GO:0051093]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reproductive process [GO:2000242]; neurofilament cytoskeleton organization [GO:0060052]; neuronal action potential [GO:0019228]; ovarian follicle development [GO:0001541]; peripheral nervous system myelin maintenance [GO:0032287]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cytokine production [GO:0001819]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of phagocytosis [GO:0050766]; positive regulation of superoxide anion generation [GO:0032930]; reactive oxygen species metabolic process [GO:0072593]; regulation of blood pressure [GO:0008217]; regulation of GTPase activity [GO:0043087]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of multicellular organism growth [GO:0040014]; regulation of organ growth [GO:0046620]; regulation of protein kinase activity [GO:0045859]; regulation of T cell differentiation in thymus [GO:0033081]; relaxation of vascular associated smooth muscle [GO:0060087]; removal of superoxide radicals [GO:0019430]; response to axon injury [GO:0048678]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to organic substance [GO:0010033]; response to superoxide [GO:0000303]; response to xenobiotic stimulus [GO:0009410]; retina homeostasis [GO:0001895]; retrograde axonal transport [GO:0008090]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]; thymus development [GO:0048538]; transmission of nerve impulse [GO:0019226]	axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein phosphatase 2B binding [GO:0030346]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270]	axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein phosphatase 2B binding [GO:0030346]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270]; action potential initiation [GO:0099610]; anterograde axonal transport [GO:0008089]; apoptotic process [GO:0006915]; auditory receptor cell stereocilium organization [GO:0060088]; determination of adult lifespan [GO:0008340]; ectopic germ cell programmed cell death [GO:0035234]; embryo implantation [GO:0007566]; gene expression [GO:0010467]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide biosynthetic process [GO:0050665]; intracellular iron ion homeostasis [GO:0006879]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; myeloid cell homeostasis [GO:0002262]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of developmental process [GO:0051093]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reproductive process [GO:2000242]; neurofilament cytoskeleton organization [GO:0060052]; neuronal action potential [GO:0019228]; ovarian follicle development [GO:0001541]; peripheral nervous system myelin maintenance [GO:0032287]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cytokine production [GO:0001819]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of phagocytosis [GO:0050766]; positive regulation of superoxide anion generation [GO:0032930]; reactive oxygen species metabolic process [GO:0072593]; regulation of blood pressure [GO:0008217]; regulation of GTPase activity [GO:0043087]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of multicellular organism growth [GO:0040014]; regulation of organ growth [GO:0046620]; regulation of protein kinase activity [GO:0045859]; regulation of T cell differentiation in thymus [GO:0033081]; relaxation of vascular associated smooth muscle [GO:0060087]; removal of superoxide radicals [GO:0019430]; response to axon injury [GO:0048678]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to organic substance [GO:0010033]; response to superoxide [GO:0000303]; response to xenobiotic stimulus [GO:0009410]; retina homeostasis [GO:0001895]; retrograde axonal transport [GO:0008090]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]; thymus development [GO:0048538]; transmission of nerve impulse [GO:0019226]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19741096}. Mitochondrion {ECO:0000269|PubMed:19741096}. Nucleus {ECO:0000269|PubMed:22496122}. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. {ECO:0000269|PubMed:19741096}.
P00450	reviewed	CERU_HUMAN	Ceruloplasmin (EC 1.16.3.1) (Ferroxidase)	CP	Homo sapiens (Human)	1065	FUNCTION: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). {ECO:0000250}.		copper ion transport [GO:0006825]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]	blood microparticle [GO:0072562]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322]; oxidoreductase activity [GO:0016491]; protein-folding chaperone binding [GO:0051087]	blood microparticle [GO:0072562]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322]; oxidoreductase activity [GO:0016491]; protein-folding chaperone binding [GO:0051087]; copper ion transport [GO:0006825]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]	SUBCELLULAR LOCATION: Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments. {ECO:0000250}.
P00451	reviewed	FA8_HUMAN	Coagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain]	F8 F8C	Homo sapiens (Human)	2351	FUNCTION: Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.		acute-phase response [GO:0006953]; blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]	copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491]; acute-phase response [GO:0006953]; blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P00480	reviewed	OTC_HUMAN	Ornithine transcarbamylase, mitochondrial (OTCase) (EC 2.1.3.3) (Ornithine carbamoyltransferase, mitochondrial)	OTC	Homo sapiens (Human)	354	FUNCTION: Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline (PubMed:6372096, PubMed:8112735, PubMed:2556444). The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion (PubMed:2556444). {ECO:0000269|PubMed:2556444, ECO:0000269|PubMed:6372096, ECO:0000269|PubMed:8112735}.		ammonium homeostasis [GO:0097272]; arginine biosynthetic process via ornithine [GO:0042450]; citrulline biosynthetic process [GO:0019240]; liver development [GO:0001889]; midgut development [GO:0007494]; monoatomic anion homeostasis [GO:0055081]; ornithine catabolic process [GO:0006593]; response to biotin [GO:0070781]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; urea cycle [GO:0000050]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; ornithine carbamoyltransferase activity [GO:0004585]; phosphate ion binding [GO:0042301]; phospholipid binding [GO:0005543]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; ornithine carbamoyltransferase activity [GO:0004585]; phosphate ion binding [GO:0042301]; phospholipid binding [GO:0005543]; ammonium homeostasis [GO:0097272]; arginine biosynthetic process via ornithine [GO:0042450]; citrulline biosynthetic process [GO:0019240]; liver development [GO:0001889]; midgut development [GO:0007494]; monoatomic anion homeostasis [GO:0055081]; ornithine catabolic process [GO:0006593]; response to biotin [GO:0070781]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; urea cycle [GO:0000050]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:3895227}.
P00488	reviewed	F13A_HUMAN	Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain)	F13A1 F13A	Homo sapiens (Human)	732	FUNCTION: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. {ECO:0000269|PubMed:27363989}.		blood coagulation [GO:0007596]; blood coagulation, fibrin clot formation [GO:0072378]; peptide cross-linking [GO:0018149]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; transferase complex [GO:1990234]	metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; transferase complex [GO:1990234]; metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; blood coagulation [GO:0007596]; blood coagulation, fibrin clot formation [GO:0072378]; peptide cross-linking [GO:0018149]	SUBCELLULAR LOCATION: Cytoplasm. Secreted {ECO:0000269|PubMed:4405643}. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
P00491	reviewed	PNPH_HUMAN	Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase)	PNP NP	Homo sapiens (Human)	289	FUNCTION: Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:9305964, PubMed:23438750). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (PubMed:9305964). {ECO:0000269|PubMed:23438750, ECO:0000269|PubMed:9305964}.		allantoin metabolic process [GO:0000255]; dAMP catabolic process [GO:0046059]; deoxyadenosine catabolic process [GO:0006157]; deoxyinosine catabolic process [GO:0006149]; immune response [GO:0006955]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; nucleotide biosynthetic process [GO:0009165]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of T cell proliferation [GO:0042102]; purine ribonucleoside salvage [GO:0006166]; purine-containing compound salvage [GO:0043101]; response to xenobiotic stimulus [GO:0009410]; urate biosynthetic process [GO:0034418]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]	guanosine phosphorylase activity [GO:0047975]; identical protein binding [GO:0042802]; nucleoside binding [GO:0001882]; phosphate ion binding [GO:0042301]; purine nucleobase binding [GO:0002060]; purine-nucleoside phosphorylase activity [GO:0004731]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; guanosine phosphorylase activity [GO:0047975]; identical protein binding [GO:0042802]; nucleoside binding [GO:0001882]; phosphate ion binding [GO:0042301]; purine nucleobase binding [GO:0002060]; purine-nucleoside phosphorylase activity [GO:0004731]; allantoin metabolic process [GO:0000255]; dAMP catabolic process [GO:0046059]; deoxyadenosine catabolic process [GO:0006157]; deoxyinosine catabolic process [GO:0006149]; immune response [GO:0006955]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; nucleotide biosynthetic process [GO:0009165]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of T cell proliferation [GO:0042102]; purine ribonucleoside salvage [GO:0006166]; purine-containing compound salvage [GO:0043101]; response to xenobiotic stimulus [GO:0009410]; urate biosynthetic process [GO:0034418]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22509282}.
P00492	reviewed	HPRT_HUMAN	Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8)	HPRT1 HPRT	Homo sapiens (Human)	218	FUNCTION: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.		adenine metabolic process [GO:0046083]; AMP salvage [GO:0044209]; central nervous system neuron development [GO:0021954]; cerebral cortex neuron differentiation [GO:0021895]; dendrite morphogenesis [GO:0048813]; dopamine metabolic process [GO:0042417]; dopaminergic neuron differentiation [GO:0071542]; GMP catabolic process [GO:0046038]; GMP salvage [GO:0032263]; grooming behavior [GO:0007625]; guanine salvage [GO:0006178]; hypoxanthine metabolic process [GO:0046100]; hypoxanthine salvage [GO:0043103]; IMP metabolic process [GO:0046040]; IMP salvage [GO:0032264]; locomotory behavior [GO:0007626]; lymphocyte proliferation [GO:0046651]; positive regulation of dopamine metabolic process [GO:0045964]; protein homotetramerization [GO:0051289]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside salvage [GO:0006166]; response to amphetamine [GO:0001975]; striatum development [GO:0021756]; T cell mediated cytotoxicity [GO:0001913]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	guanine phosphoribosyltransferase activity [GO:0052657]; hypoxanthine phosphoribosyltransferase activity [GO:0004422]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; guanine phosphoribosyltransferase activity [GO:0052657]; hypoxanthine phosphoribosyltransferase activity [GO:0004422]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; adenine metabolic process [GO:0046083]; AMP salvage [GO:0044209]; central nervous system neuron development [GO:0021954]; cerebral cortex neuron differentiation [GO:0021895]; dendrite morphogenesis [GO:0048813]; dopamine metabolic process [GO:0042417]; dopaminergic neuron differentiation [GO:0071542]; GMP catabolic process [GO:0046038]; GMP salvage [GO:0032263]; grooming behavior [GO:0007625]; guanine salvage [GO:0006178]; hypoxanthine metabolic process [GO:0046100]; hypoxanthine salvage [GO:0043103]; IMP metabolic process [GO:0046040]; IMP salvage [GO:0032264]; locomotory behavior [GO:0007626]; lymphocyte proliferation [GO:0046651]; positive regulation of dopamine metabolic process [GO:0045964]; protein homotetramerization [GO:0051289]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside salvage [GO:0006166]; response to amphetamine [GO:0001975]; striatum development [GO:0021756]; T cell mediated cytotoxicity [GO:0001913]	SUBCELLULAR LOCATION: Cytoplasm.
P00505	reviewed	AATM_HUMAN	Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)	GOT2 KYAT4	Homo sapiens (Human)	430	FUNCTION: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:31422819, ECO:0000269|PubMed:9537447}.	MISCELLANEOUS: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.	2-oxoglutarate metabolic process [GO:0006103]; 4-hydroxyproline catabolic process [GO:0019470]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; fatty acid transport [GO:0015908]; glutamate catabolic process to 2-oxoglutarate [GO:0019551]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; oxaloacetate metabolic process [GO:0006107]; response to ethanol [GO:0045471]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	kynurenine-oxoglutarate transaminase activity [GO:0016212]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; pyridoxal phosphate binding [GO:0030170]; RNA binding [GO:0003723]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; pyridoxal phosphate binding [GO:0030170]; RNA binding [GO:0003723]; 2-oxoglutarate metabolic process [GO:0006103]; 4-hydroxyproline catabolic process [GO:0019470]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; fatty acid transport [GO:0015908]; glutamate catabolic process to 2-oxoglutarate [GO:0019551]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; oxaloacetate metabolic process [GO:0006107]; response to ethanol [GO:0045471]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:9537447}. Cell membrane {ECO:0000269|PubMed:9537447}. Note=Exposure to alcohol promotes translocation to the cell membrane. {ECO:0000269|PubMed:9537447}.
P00519	reviewed	ABL1_HUMAN	Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)	ABL1 ABL JTK7	Homo sapiens (Human)	1130	FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.		actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; activated T cell proliferation [GO:0050798]; activation of protein kinase C activity [GO:1990051]; alpha-beta T cell differentiation [GO:0046632]; associative learning [GO:0008306]; autophagy [GO:0006914]; B cell proliferation involved in immune response [GO:0002322]; B cell receptor signaling pathway [GO:0050853]; B-1 B cell homeostasis [GO:0001922]; Bergmann glial cell differentiation [GO:0060020]; BMP signaling pathway [GO:0030509]; canonical NF-kappaB signal transduction [GO:0007249]; cardiac muscle cell proliferation [GO:0060038]; cell-cell adhesion [GO:0098609]; cellular response to dopamine [GO:1903351]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular senescence [GO:0090398]; cerebellum morphogenesis [GO:0021587]; DN4 thymocyte differentiation [GO:1904157]; DNA conformation change [GO:0071103]; DNA damage response [GO:0006974]; endothelial cell migration [GO:0043542]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERK1 and ERK2 cascade [GO:0070371]; establishment of localization in cell [GO:0051649]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; integrin-mediated signaling pathway [GO:0007229]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; microspike assembly [GO:0030035]; mismatch repair [GO:0006298]; mitochondrial depolarization [GO:0051882]; mitotic cell cycle [GO:0000278]; myoblast proliferation [GO:0051450]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cellular senescence [GO:2000773]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phospholipase C activity [GO:1900275]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; neural tube closure [GO:0001843]; neuroepithelial cell differentiation [GO:0060563]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neuropilin signaling pathway [GO:0038189]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; podocyte apoptotic process [GO:1903210]; positive regulation of actin filament binding [GO:1904531]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood vessel branching [GO:1905555]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendrite development [GO:1900006]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of microtubule binding [GO:1904528]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of oxidoreductase activity [GO:0051353]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of vasoconstriction [GO:0045907]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; post-embryonic development [GO:0009791]; protein autophosphorylation [GO:0046777]; protein localization to cytoplasmic microtubule plus-end [GO:1904518]; protein modification process [GO:0036211]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of axon extension [GO:0030516]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of cell motility [GO:2000145]; regulation of DNA-templated transcription [GO:0006355]; regulation of endocytosis [GO:0030100]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of microtubule polymerization [GO:0031113]; regulation of modification of synaptic structure [GO:1905244]; regulation of T cell differentiation [GO:0045580]; response to endoplasmic reticulum stress [GO:0034976]; response to epinephrine [GO:0071871]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]; signal transduction in response to DNA damage [GO:0042770]; spleen development [GO:0048536]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; transitional one stage B cell differentiation [GO:0002333]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; growth cone [GO:0030426]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]	actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; bubble DNA binding [GO:0000405]; delta-catenin binding [GO:0070097]; DNA binding [GO:0003677]; ephrin receptor binding [GO:0046875]; four-way junction DNA binding [GO:0000400]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; mitogen-activated protein kinase binding [GO:0051019]; neuropilin binding [GO:0038191]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; proline-rich region binding [GO:0070064]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein self-association [GO:0043621]; protein tyrosine kinase activity [GO:0004713]; sequence-specific double-stranded DNA binding [GO:1990837]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; syntaxin binding [GO:0019905]; transcription coactivator activity [GO:0003713]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; growth cone [GO:0030426]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; bubble DNA binding [GO:0000405]; delta-catenin binding [GO:0070097]; DNA binding [GO:0003677]; ephrin receptor binding [GO:0046875]; four-way junction DNA binding [GO:0000400]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; mitogen-activated protein kinase binding [GO:0051019]; neuropilin binding [GO:0038191]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; proline-rich region binding [GO:0070064]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein self-association [GO:0043621]; protein tyrosine kinase activity [GO:0004713]; sequence-specific double-stranded DNA binding [GO:1990837]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; syntaxin binding [GO:0019905]; transcription coactivator activity [GO:0003713]; actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; activated T cell proliferation [GO:0050798]; activation of protein kinase C activity [GO:1990051]; alpha-beta T cell differentiation [GO:0046632]; associative learning [GO:0008306]; autophagy [GO:0006914]; B cell proliferation involved in immune response [GO:0002322]; B cell receptor signaling pathway [GO:0050853]; B-1 B cell homeostasis [GO:0001922]; Bergmann glial cell differentiation [GO:0060020]; BMP signaling pathway [GO:0030509]; canonical NF-kappaB signal transduction [GO:0007249]; cardiac muscle cell proliferation [GO:0060038]; cell-cell adhesion [GO:0098609]; cellular response to dopamine [GO:1903351]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular senescence [GO:0090398]; cerebellum morphogenesis [GO:0021587]; DN4 thymocyte differentiation [GO:1904157]; DNA conformation change [GO:0071103]; DNA damage response [GO:0006974]; endothelial cell migration [GO:0043542]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERK1 and ERK2 cascade [GO:0070371]; establishment of localization in cell [GO:0051649]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; integrin-mediated signaling pathway [GO:0007229]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; microspike assembly [GO:0030035]; mismatch repair [GO:0006298]; mitochondrial depolarization [GO:0051882]; mitotic cell cycle [GO:0000278]; myoblast proliferation [GO:0051450]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cellular senescence [GO:2000773]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phospholipase C activity [GO:1900275]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; neural tube closure [GO:0001843]; neuroepithelial cell differentiation [GO:0060563]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neuropilin signaling pathway [GO:0038189]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; podocyte apoptotic process [GO:1903210]; positive regulation of actin filament binding [GO:1904531]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood vessel branching [GO:1905555]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendrite development [GO:1900006]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of microtubule binding [GO:1904528]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of oxidoreductase activity [GO:0051353]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of vasoconstriction [GO:0045907]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; post-embryonic development [GO:0009791]; protein autophosphorylation [GO:0046777]; protein localization to cytoplasmic microtubule plus-end [GO:1904518]; protein modification process [GO:0036211]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of axon extension [GO:0030516]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of cell motility [GO:2000145]; regulation of DNA-templated transcription [GO:0006355]; regulation of endocytosis [GO:0030100]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of microtubule polymerization [GO:0031113]; regulation of modification of synaptic structure [GO:1905244]; regulation of T cell differentiation [GO:0045580]; response to endoplasmic reticulum stress [GO:0034976]; response to epinephrine [GO:0071871]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]; signal transduction in response to DNA damage [GO:0042770]; spleen development [GO:0048536]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; transitional one stage B cell differentiation [GO:0002333]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Nucleus. Mitochondrion {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform IB]: Nucleus membrane; Lipid-anchor. Note=The myristoylated c-ABL protein is reported to be nuclear.
P00533	reviewed	EGFR_HUMAN	Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)	EGFR ERBB ERBB1 HER1	Homo sapiens (Human)	1210	FUNCTION: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.		activation of phospholipase C activity [GO:0007202]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cellular response to amino acid stimulus [GO:0071230]; cellular response to cadmium ion [GO:0071276]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; digestive tract morphogenesis [GO:0048546]; embryonic placenta development [GO:0001892]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation [GO:0050673]; ERBB2-EGFR signaling pathway [GO:0038134]; eyelid development in camera-type eye [GO:0061029]; hair follicle development [GO:0001942]; learning or memory [GO:0007611]; morphogenesis of an epithelial fold [GO:0060571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiocyte differentiation [GO:1905208]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of protein catabolic process [GO:0042177]; neurogenesis [GO:0022008]; ossification [GO:0001503]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; protein insertion into membrane [GO:0051205]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of JNK cascade [GO:0046328]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; response to UV-A [GO:0070141]; salivary gland morphogenesis [GO:0007435]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular vesicle [GO:0097708]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body, internal vesicle lumen [GO:0097489]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; Shc-EGFR complex [GO:0070435]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor activity [GO:0005006]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; MAP kinase kinase kinase activity [GO:0004709]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; ubiquitin protein ligase binding [GO:0031625]; virus receptor activity [GO:0001618]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular vesicle [GO:0097708]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body, internal vesicle lumen [GO:0097489]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; Shc-EGFR complex [GO:0070435]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor activity [GO:0005006]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; MAP kinase kinase kinase activity [GO:0004709]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; ubiquitin protein ligase binding [GO:0031625]; virus receptor activity [GO:0001618]; activation of phospholipase C activity [GO:0007202]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cellular response to amino acid stimulus [GO:0071230]; cellular response to cadmium ion [GO:0071276]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; digestive tract morphogenesis [GO:0048546]; embryonic placenta development [GO:0001892]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation [GO:0050673]; ERBB2-EGFR signaling pathway [GO:0038134]; eyelid development in camera-type eye [GO:0061029]; hair follicle development [GO:0001942]; learning or memory [GO:0007611]; morphogenesis of an epithelial fold [GO:0060571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiocyte differentiation [GO:1905208]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of protein catabolic process [GO:0042177]; neurogenesis [GO:0022008]; ossification [GO:0001503]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; protein insertion into membrane [GO:0051205]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of JNK cascade [GO:0046328]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; response to UV-A [GO:0070141]; salivary gland morphogenesis [GO:0007435]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17182860, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960}; Single-pass type I membrane protein {ECO:0000269|PubMed:27153536}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27153536}; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome {ECO:0000269|PubMed:17182860, ECO:0000269|PubMed:27153536}. Endosome membrane. Nucleus {ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:20551055, ECO:0000269|PubMed:20674546}. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). {ECO:0000269|PubMed:17182860, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:20674546, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
P00540	reviewed	MOS_HUMAN	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Proto-oncogene c-Mos)	MOS	Homo sapiens (Human)	346			chromatin organization [GO:0006325]; establishment of meiotic spindle orientation [GO:0051296]; MAPK cascade [GO:0000165]; meiotic spindle organization [GO:0000212]; negative regulation of metaphase/anaphase transition of meiotic cell cycle [GO:1902103]; positive regulation of MAPK cascade [GO:0043410]; protein autophosphorylation [GO:0046777]; regulation of meiotic nuclear division [GO:0040020]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; chromatin organization [GO:0006325]; establishment of meiotic spindle orientation [GO:0051296]; MAPK cascade [GO:0000165]; meiotic spindle organization [GO:0000212]; negative regulation of metaphase/anaphase transition of meiotic cell cycle [GO:1902103]; positive regulation of MAPK cascade [GO:0043410]; protein autophosphorylation [GO:0046777]; regulation of meiotic nuclear division [GO:0040020]; signal transduction [GO:0007165]	
P00558	reviewed	PGK1_HUMAN	Phosphoglycerate kinase 1 (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2)	PGK1 PGKA MIG10 OK/SW-cl.110	Homo sapiens (Human)	417	FUNCTION: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:7391028}.		canonical glycolysis [GO:0061621]; cellular response to hypoxia [GO:0071456]; epithelial cell differentiation [GO:0030855]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; negative regulation of angiogenesis [GO:0016525]; phosphorylation [GO:0016310]; plasminogen activation [GO:0031639]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]; protein-disulfide reductase (NAD(P)) activity [GO:0047134]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]; protein-disulfide reductase (NAD(P)) activity [GO:0047134]; canonical glycolysis [GO:0061621]; cellular response to hypoxia [GO:0071456]; epithelial cell differentiation [GO:0030855]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; negative regulation of angiogenesis [GO:0016525]; phosphorylation [GO:0016310]; plasminogen activation [GO:0031639]	SUBCELLULAR LOCATION: Cytoplasm.
P00568	reviewed	KAD1_HUMAN	Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.10) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase)	AK1	Homo sapiens (Human)	194	FUNCTION: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP (PubMed:2542324). Exhibits nucleoside diphosphate kinase activity, catalyzing the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and dTTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor (PubMed:23416111). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity). {ECO:0000250|UniProtKB:P05081, ECO:0000255|HAMAP-Rule:MF_03171, ECO:0000269|PubMed:23416111, ECO:0000269|PubMed:2542324}.		ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleoside triphosphate biosynthetic process [GO:0009142]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; outer dense fiber [GO:0001520]	adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside triphosphate adenylate kinase activity [GO:0046899]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; outer dense fiber [GO:0001520]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside triphosphate adenylate kinase activity [GO:0046899]; ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleoside triphosphate biosynthetic process [GO:0009142]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P05081}.
P00709	reviewed	LALBA_HUMAN	Alpha-lactalbumin (Lactose synthase B protein) (Lysozyme-like protein 7)	LALBA LYZL7	Homo sapiens (Human)	142	FUNCTION: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.		apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; defense response to bacterium [GO:0042742]; lactose biosynthetic process [GO:0005989]; signal transduction [GO:0007165]	extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; protein-containing complex [GO:0032991]	calcium ion binding [GO:0005509]; lactose synthase activity [GO:0004461]; lysozyme activity [GO:0003796]	extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; protein-containing complex [GO:0032991]; calcium ion binding [GO:0005509]; lactose synthase activity [GO:0004461]; lysozyme activity [GO:0003796]; apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; defense response to bacterium [GO:0042742]; lactose biosynthetic process [GO:0005989]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P00734	reviewed	THRB_HUMAN	Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]	F2	Homo sapiens (Human)	622	FUNCTION: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. {ECO:0000269|PubMed:2856554}.	MISCELLANEOUS: It is not known whether 1 or 2 smaller activation peptides, with additional cleavage after Arg-314, are released in natural blood clotting.; MISCELLANEOUS: Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin, prior to its activation by factor Xa.; MISCELLANEOUS: The cleavage after Arg-198, observed in vitro, does not occur in plasma.	acute-phase response [GO:0006953]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; blood coagulation [GO:0007596]; cell surface receptor signaling pathway [GO:0007166]; cytolysis by host of symbiont cells [GO:0051838]; fibrinolysis [GO:0042730]; G protein-coupled receptor signaling pathway [GO:0007186]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of platelet activation [GO:0010544]; negative regulation of proteolysis [GO:0045861]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; platelet activation [GO:0030168]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of insulin secretion [GO:0032024]; positive regulation of lipid kinase activity [GO:0090218]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; proteolysis [GO:0006508]; regulation of blood coagulation [GO:0030193]; regulation of cell shape [GO:0008360]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to wounding [GO:0009611]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; lipopolysaccharide binding [GO:0001530]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]; thrombospondin receptor activity [GO:0070053]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; lipopolysaccharide binding [GO:0001530]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]; thrombospondin receptor activity [GO:0070053]; acute-phase response [GO:0006953]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; blood coagulation [GO:0007596]; cell surface receptor signaling pathway [GO:0007166]; cytolysis by host of symbiont cells [GO:0051838]; fibrinolysis [GO:0042730]; G protein-coupled receptor signaling pathway [GO:0007186]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of platelet activation [GO:0010544]; negative regulation of proteolysis [GO:0045861]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; platelet activation [GO:0030168]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of insulin secretion [GO:0032024]; positive regulation of lipid kinase activity [GO:0090218]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; proteolysis [GO:0006508]; regulation of blood coagulation [GO:0030193]; regulation of cell shape [GO:0008360]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P00736	reviewed	C1R_HUMAN	Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain]	C1R	Homo sapiens (Human)	705	FUNCTION: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.		complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; innate immune response [GO:0045087]; zymogen activation [GO:0031638]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; innate immune response [GO:0045087]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27745832}.
P00738	reviewed	HPT_HUMAN	Haptoglobin (Zonulin) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain]	HP	Homo sapiens (Human)	406	FUNCTION: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. {ECO:0000269|PubMed:21248165}.; FUNCTION: The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. {ECO:0000269|PubMed:21248165}.		acute-phase response [GO:0006953]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; immune system process [GO:0002376]; negative regulation of hydrogen peroxide catabolic process [GO:2000296]; negative regulation of oxidoreductase activity [GO:0051354]; response to hydrogen peroxide [GO:0042542]	blood microparticle [GO:0072562]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; haptoglobin-hemoglobin complex [GO:0031838]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	antioxidant activity [GO:0016209]; hemoglobin binding [GO:0030492]; serine-type endopeptidase activity [GO:0004252]	blood microparticle [GO:0072562]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; haptoglobin-hemoglobin complex [GO:0031838]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; antioxidant activity [GO:0016209]; hemoglobin binding [GO:0030492]; serine-type endopeptidase activity [GO:0004252]; acute-phase response [GO:0006953]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; immune system process [GO:0002376]; negative regulation of hydrogen peroxide catabolic process [GO:2000296]; negative regulation of oxidoreductase activity [GO:0051354]; response to hydrogen peroxide [GO:0042542]	SUBCELLULAR LOCATION: Secreted.
P00739	reviewed	HPTR_HUMAN	Haptoglobin-related protein	HPR	Homo sapiens (Human)	348	FUNCTION: Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron. {ECO:0000269|PubMed:16778136}.			blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; spherical high-density lipoprotein particle [GO:0034366]	hemoglobin binding [GO:0030492]; serine-type endopeptidase activity [GO:0004252]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; spherical high-density lipoprotein particle [GO:0034366]; hemoglobin binding [GO:0030492]; serine-type endopeptidase activity [GO:0004252]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16778136}. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL). {ECO:0000269|PubMed:16778136}.
P00740	reviewed	FA9_HUMAN	Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]	F9	Homo sapiens (Human)	461	FUNCTION: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. {ECO:0000269|PubMed:1730085, ECO:0000269|PubMed:19846852, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0000269|PubMed:2592373, ECO:0000269|PubMed:8295821}.	MISCELLANEOUS: In 1952, one of the earliest researchers of the disease, Dr. R.G. Macfarlane used the patient's surname, Christmas, to refer to the disease and also to refer to the clotting factor which he called the 'Christmas Factor'. At the time, Stephen Christmas was a 5-year-old boy. He died in 1993 at the age of 46 from acquired immunodeficiency syndrome contracted through treatment with blood products.	blood coagulation [GO:0007596]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; blood coagulation [GO:0007596]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19846852, ECO:0000269|PubMed:2592373, ECO:0000269|PubMed:3857619, ECO:0000269|PubMed:8295821, ECO:0000269|PubMed:9169594}.
P00742	reviewed	FA10_HUMAN	Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]	F10	Homo sapiens (Human)	488	FUNCTION: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.		blood coagulation [GO:0007596]; positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; proteolysis [GO:0006508]	endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543]; serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543]; serine-type endopeptidase activity [GO:0004252]; blood coagulation [GO:0007596]; positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
P00746	reviewed	CFAD_HUMAN	Complement factor D (EC 3.4.21.46) (Adipsin) (C3 convertase activator) (Properdin factor D)	CFD DF PFD	Homo sapiens (Human)	253	FUNCTION: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.		complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Secreted.
P00747	reviewed	PLMN_HUMAN	Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]	PLG	Homo sapiens (Human)	810	FUNCTION: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093}.; FUNCTION: Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. {ECO:0000269|PubMed:14699093}.; FUNCTION: (Microbial infection) ENO/enoloase from parasite P.falciparum (strain NF54) interacts with PLG present in the mosquito blood meal to promote the invasion of the mosquito midgut by the parasite ookinete (PubMed:21949403). The catalytic active form, plasmin, is essential for the invasion of the mosquito midgut (PubMed:21949403). {ECO:0000269|PubMed:21949403}.; FUNCTION: (Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue. {ECO:0000269|PubMed:22433849}.	MISCELLANEOUS: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.	biological process involved in interaction with symbiont [GO:0051702]; blood coagulation [GO:0007596]; extracellular matrix disassembly [GO:0022617]; fibrinolysis [GO:0042730]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of fibrinolysis [GO:0051919]; proteolysis [GO:0006508]; tissue remodeling [GO:0048771]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]	apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein antigen binding [GO:1990405]; protein domain specific binding [GO:0019904]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein antigen binding [GO:1990405]; protein domain specific binding [GO:0019904]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102]; biological process involved in interaction with symbiont [GO:0051702]; blood coagulation [GO:0007596]; extracellular matrix disassembly [GO:0022617]; fibrinolysis [GO:0042730]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of fibrinolysis [GO:0051919]; proteolysis [GO:0006508]; tissue remodeling [GO:0048771]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10077593, ECO:0000269|PubMed:14699093}. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
P00748	reviewed	FA12_HUMAN	Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]	F12	Homo sapiens (Human)	615	FUNCTION: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. {ECO:0000269|PubMed:21304106}.		blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; Factor XII activation [GO:0002542]; fibrinolysis [GO:0042730]; innate immune response [GO:0045087]; plasma kallikrein-kinin cascade [GO:0002353]; positive regulation of blood coagulation [GO:0030194]; positive regulation of fibrinolysis [GO:0051919]; positive regulation of plasminogen activation [GO:0010756]; protein autoprocessing [GO:0016540]; protein processing [GO:0016485]; response to misfolded protein [GO:0051788]; zymogen activation [GO:0031638]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]	calcium ion binding [GO:0005509]; misfolded protein binding [GO:0051787]; serine-type endopeptidase activity [GO:0004252]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; calcium ion binding [GO:0005509]; misfolded protein binding [GO:0051787]; serine-type endopeptidase activity [GO:0004252]; blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; Factor XII activation [GO:0002542]; fibrinolysis [GO:0042730]; innate immune response [GO:0045087]; plasma kallikrein-kinin cascade [GO:0002353]; positive regulation of blood coagulation [GO:0030194]; positive regulation of fibrinolysis [GO:0051919]; positive regulation of plasminogen activation [GO:0010756]; protein autoprocessing [GO:0016540]; protein processing [GO:0016485]; response to misfolded protein [GO:0051788]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Secreted.
P00749	reviewed	UROK_HUMAN	Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]	PLAU	Homo sapiens (Human)	431	FUNCTION: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.		blood coagulation [GO:0007596]; chemotaxis [GO:0006935]; fibrinolysis [GO:0042730]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; plasminogen activation [GO:0031639]; positive regulation of cell migration [GO:0030335]; proteolysis [GO:0006508]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell population proliferation [GO:0042127]; regulation of fibrinolysis [GO:0051917]; regulation of plasminogen activation [GO:0010755]; regulation of signaling receptor activity [GO:0010469]; regulation of smooth muscle cell migration [GO:0014910]; regulation of smooth muscle cell-matrix adhesion [GO:2000097]; regulation of wound healing [GO:0061041]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; smooth muscle cell migration [GO:0014909]; urokinase plasminogen activator signaling pathway [GO:0038195]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; protein complex involved in cell-matrix adhesion [GO:0098637]; serine protease inhibitor complex [GO:0097180]; serine-type endopeptidase complex [GO:1905370]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	serine-type endopeptidase activity [GO:0004252]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; protein complex involved in cell-matrix adhesion [GO:0098637]; serine protease inhibitor complex [GO:0097180]; serine-type endopeptidase complex [GO:1905370]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; serine-type endopeptidase activity [GO:0004252]; blood coagulation [GO:0007596]; chemotaxis [GO:0006935]; fibrinolysis [GO:0042730]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; plasminogen activation [GO:0031639]; positive regulation of cell migration [GO:0030335]; proteolysis [GO:0006508]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell population proliferation [GO:0042127]; regulation of fibrinolysis [GO:0051917]; regulation of plasminogen activation [GO:0010755]; regulation of signaling receptor activity [GO:0010469]; regulation of smooth muscle cell migration [GO:0014910]; regulation of smooth muscle cell-matrix adhesion [GO:2000097]; regulation of wound healing [GO:0061041]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; smooth muscle cell migration [GO:0014909]; urokinase plasminogen activator signaling pathway [GO:0038195]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24434139}.
P00750	reviewed	TPA_HUMAN	Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]	PLAT	Homo sapiens (Human)	562	FUNCTION: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P19637}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of proteolysis [GO:0045861]; plasminogen activation [GO:0031639]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; prevention of polyspermy [GO:0060468]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; response to hypoxia [GO:0001666]; smooth muscle cell migration [GO:0014909]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]	apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; serine protease inhibitor complex [GO:0097180]	phosphoprotein binding [GO:0051219]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]	apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; serine protease inhibitor complex [GO:0097180]; phosphoprotein binding [GO:0051219]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]; blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of proteolysis [GO:0045861]; plasminogen activation [GO:0031639]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; prevention of polyspermy [GO:0060468]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; response to hypoxia [GO:0001666]; smooth muscle cell migration [GO:0014909]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P00751	reviewed	CFAB_HUMAN	Complement factor B (EC 3.4.21.47) (C3/C5 convertase) (Glycine-rich beta glycoprotein) (GBG) (PBF2) (Properdin factor B) [Cleaved into: Complement factor B Ba fragment; Complement factor B Bb fragment]	CFB BF BFD	Homo sapiens (Human)	764	FUNCTION: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.		complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]	blood microparticle [GO:0072562]; classical-complement-pathway C3/C5 convertase complex [GO:0005601]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	complement binding [GO:0001848]; serine-type endopeptidase activity [GO:0004252]	blood microparticle [GO:0072562]; classical-complement-pathway C3/C5 convertase complex [GO:0005601]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; complement binding [GO:0001848]; serine-type endopeptidase activity [GO:0004252]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Secreted.
P00797	reviewed	RENI_HUMAN	Renin (EC 3.4.23.15) (Angiotensinogenase)	REN	Homo sapiens (Human)	406	FUNCTION: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. {ECO:0000269|PubMed:12045255, ECO:0000269|PubMed:20927107}.		amyloid-beta metabolic process [GO:0050435]; angiotensin maturation [GO:0002003]; cell maturation [GO:0048469]; cellular response to xenobiotic stimulus [GO:0071466]; drinking behavior [GO:0042756]; hormone-mediated signaling pathway [GO:0009755]; juxtaglomerular apparatus development [GO:0072051]; kidney development [GO:0001822]; male gonad development [GO:0008584]; mesonephros development [GO:0001823]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of MAPK cascade [GO:0043408]; renin-angiotensin regulation of aldosterone production [GO:0002018]; response to cAMP [GO:0051591]; response to cGMP [GO:0070305]; response to immobilization stress [GO:0035902]; response to lipopolysaccharide [GO:0032496]	apical part of cell [GO:0045177]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	aspartic-type endopeptidase activity [GO:0004190]; insulin-like growth factor receptor binding [GO:0005159]; peptidase activity [GO:0008233]; signaling receptor binding [GO:0005102]	apical part of cell [GO:0045177]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; aspartic-type endopeptidase activity [GO:0004190]; insulin-like growth factor receptor binding [GO:0005159]; peptidase activity [GO:0008233]; signaling receptor binding [GO:0005102]; amyloid-beta metabolic process [GO:0050435]; angiotensin maturation [GO:0002003]; cell maturation [GO:0048469]; cellular response to xenobiotic stimulus [GO:0071466]; drinking behavior [GO:0042756]; hormone-mediated signaling pathway [GO:0009755]; juxtaglomerular apparatus development [GO:0072051]; kidney development [GO:0001822]; male gonad development [GO:0008584]; mesonephros development [GO:0001823]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of MAPK cascade [GO:0043408]; renin-angiotensin regulation of aldosterone production [GO:0002018]; response to cAMP [GO:0051591]; response to cGMP [GO:0070305]; response to immobilization stress [GO:0035902]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12045255}. Membrane {ECO:0000269|PubMed:12045255}. Note=Associated to membranes via binding to ATP6AP2. {ECO:0000269|PubMed:12045255}.
P00813	reviewed	ADA_HUMAN	Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)	ADA ADA1	Homo sapiens (Human)	363	FUNCTION: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:8452534, PubMed:16670267, PubMed:23193172, PubMed:9361033, PubMed:26166670). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity). {ECO:0000250|UniProtKB:P03958, ECO:0000250|UniProtKB:P56658, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:15016824, ECO:0000269|PubMed:16670267, ECO:0000269|PubMed:20959412, ECO:0000269|PubMed:21919946, ECO:0000269|PubMed:23193172, ECO:0000269|PubMed:26166670, ECO:0000269|PubMed:8452534, ECO:0000269|PubMed:9361033}.		adenosine catabolic process [GO:0006154]; adenosine metabolic process [GO:0046085]; allantoin metabolic process [GO:0000255]; alpha-beta T cell differentiation [GO:0046632]; amide catabolic process [GO:0043605]; AMP catabolic process [GO:0006196]; AMP salvage [GO:0044209]; B cell proliferation [GO:0042100]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; dAMP catabolic process [GO:0046059]; dATP catabolic process [GO:0046061]; deoxyadenosine catabolic process [GO:0006157]; embryonic digestive tract development [GO:0048566]; germinal center B cell differentiation [GO:0002314]; germinal center formation [GO:0002467]; GMP salvage [GO:0032263]; hypoxanthine salvage [GO:0043103]; inosine biosynthetic process [GO:0046103]; leukocyte migration [GO:0050900]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; mature B cell apoptotic process [GO:0002901]; mucus secretion [GO:0070254]; negative regulation of adenosine receptor signaling pathway [GO:0060169]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of mucus secretion [GO:0070256]; negative regulation of penile erection [GO:0060407]; negative regulation of thymocyte apoptotic process [GO:0070244]; penile erection [GO:0043084]; Peyer's patch development [GO:0048541]; placenta development [GO:0001890]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of germinal center formation [GO:0002636]; positive regulation of heart rate [GO:0010460]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of T cell receptor signaling pathway [GO:0050862]; purine nucleotide salvage [GO:0032261]; purine-containing compound salvage [GO:0043101]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to purine-containing compound [GO:0014074]; smooth muscle contraction [GO:0006939]; T cell activation [GO:0042110]; T cell differentiation in thymus [GO:0033077]; T cell receptor signaling pathway [GO:0050852]; thymocyte apoptotic process [GO:0070242]; trophectodermal cell differentiation [GO:0001829]; xanthine biosynthetic process [GO:0046111]; xenobiotic metabolic process [GO:0006805]	anchoring junction [GO:0070161]; cell surface [GO:0009986]; cytoplasmic vesicle lumen [GO:0060205]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]	2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; deaminase activity [GO:0019239]; zinc ion binding [GO:0008270]	anchoring junction [GO:0070161]; cell surface [GO:0009986]; cytoplasmic vesicle lumen [GO:0060205]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; 2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; deaminase activity [GO:0019239]; zinc ion binding [GO:0008270]; adenosine catabolic process [GO:0006154]; adenosine metabolic process [GO:0046085]; allantoin metabolic process [GO:0000255]; alpha-beta T cell differentiation [GO:0046632]; amide catabolic process [GO:0043605]; AMP catabolic process [GO:0006196]; AMP salvage [GO:0044209]; B cell proliferation [GO:0042100]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; dAMP catabolic process [GO:0046059]; dATP catabolic process [GO:0046061]; deoxyadenosine catabolic process [GO:0006157]; embryonic digestive tract development [GO:0048566]; germinal center B cell differentiation [GO:0002314]; germinal center formation [GO:0002467]; GMP salvage [GO:0032263]; hypoxanthine salvage [GO:0043103]; inosine biosynthetic process [GO:0046103]; leukocyte migration [GO:0050900]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; mature B cell apoptotic process [GO:0002901]; mucus secretion [GO:0070254]; negative regulation of adenosine receptor signaling pathway [GO:0060169]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of mucus secretion [GO:0070256]; negative regulation of penile erection [GO:0060407]; negative regulation of thymocyte apoptotic process [GO:0070244]; penile erection [GO:0043084]; Peyer's patch development [GO:0048541]; placenta development [GO:0001890]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of germinal center formation [GO:0002636]; positive regulation of heart rate [GO:0010460]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of T cell receptor signaling pathway [GO:0050862]; purine nucleotide salvage [GO:0032261]; purine-containing compound salvage [GO:0043101]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to purine-containing compound [GO:0014074]; smooth muscle contraction [GO:0006939]; T cell activation [GO:0042110]; T cell differentiation in thymus [GO:0033077]; T cell receptor signaling pathway [GO:0050852]; thymocyte apoptotic process [GO:0070242]; trophectodermal cell differentiation [GO:0001829]; xanthine biosynthetic process [GO:0046111]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:8101391}; Peripheral membrane protein; Extracellular side. Cell junction {ECO:0000269|PubMed:11772392}. Cytoplasmic vesicle lumen {ECO:0000250|UniProtKB:P03958}. Cytoplasm {ECO:0000250}. Lysosome {ECO:0000269|PubMed:8452534}. Note=Colocalized with DPP4 at the cell surface. {ECO:0000269|PubMed:11772392}.
P00846	reviewed	ATP6_HUMAN	ATP synthase subunit a (F-ATPase protein 6)	MT-ATP6 ATP6 ATPASE6 MTATP6	Homo sapiens (Human)	226	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.		proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to hyperoxia [GO:0055093]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]	proton transmembrane transporter activity [GO:0015078]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]; proton transmembrane transporter activity [GO:0015078]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to hyperoxia [GO:0055093]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
P00915	reviewed	CAH1_HUMAN	Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase B) (CAB) (Carbonic anhydrase I) (CA-I) (Cyanamide hydratase CA1) (EC 4.2.1.69)	CA1	Homo sapiens (Human)	261	FUNCTION: Catalyzes the reversible hydration of carbon dioxide (PubMed:10550681, PubMed:18618712, PubMed:16807956, PubMed:16686544, PubMed:17127057, PubMed:19186056, PubMed:19206230, PubMed:16506782, PubMed:17314045, PubMed:17407288). Can hydrate cyanamide to urea (PubMed:10550681). {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:16506782, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17407288, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230}.		one-carbon metabolic process [GO:0006730]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	arylesterase activity [GO:0004064]; carbonate dehydratase activity [GO:0004089]; cyanamide hydratase activity [GO:0018820]; hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; arylesterase activity [GO:0004064]; carbonate dehydratase activity [GO:0004089]; cyanamide hydratase activity [GO:0018820]; hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270]; one-carbon metabolic process [GO:0006730]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B0BNN3}.
P00918	reviewed	CAH2_HUMAN	Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69)	CA2	Homo sapiens (Human)	260	FUNCTION: Catalyzes the reversible hydration of carbon dioxide (PubMed:1909891, PubMed:1910042, PubMed:1336460, PubMed:8485129, PubMed:8399159, PubMed:8218160, PubMed:8262987, PubMed:8451242, PubMed:7901850, PubMed:7761440, PubMed:8639494, PubMed:9265618, PubMed:17330962, PubMed:9398308, PubMed:11327835, PubMed:12056894, PubMed:17346964, PubMed:12171926, PubMed:15453828, PubMed:16214338, PubMed:15865431, PubMed:16106378, PubMed:15300855, PubMed:15667203, PubMed:18942852, PubMed:11831900, PubMed:17251017, PubMed:17314045, PubMed:18618712, PubMed:1336460, PubMed:11802772, PubMed:14736236, PubMed:16290146, PubMed:16759856, PubMed:16807956, PubMed:16686544, PubMed:17705204, PubMed:17127057, PubMed:17540563, PubMed:17588751, PubMed:18266323, PubMed:18024029, PubMed:18162396, PubMed:18374572, PubMed:18640037, PubMed:18481843, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19778001, PubMed:19520834). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}.	MISCELLANEOUS: Target of drugs used in treatments against glaucoma disorder and breast cancer. {ECO:0000269|PubMed:17251017}.	angiotensin-activated signaling pathway [GO:0038166]; carbon dioxide transport [GO:0015670]; morphogenesis of an epithelium [GO:0002009]; neuron cellular homeostasis [GO:0070050]; one-carbon metabolic process [GO:0006730]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of dipeptide transmembrane transport [GO:2001150]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of chloride transport [GO:2001225]; regulation of intracellular pH [GO:0051453]; regulation of monoatomic anion transport [GO:0044070]; secretion [GO:0046903]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]	arylesterase activity [GO:0004064]; carbonate dehydratase activity [GO:0004089]; cyanamide hydratase activity [GO:0018820]; zinc ion binding [GO:0008270]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; arylesterase activity [GO:0004064]; carbonate dehydratase activity [GO:0004089]; cyanamide hydratase activity [GO:0018820]; zinc ion binding [GO:0008270]; angiotensin-activated signaling pathway [GO:0038166]; carbon dioxide transport [GO:0015670]; morphogenesis of an epithelium [GO:0002009]; neuron cellular homeostasis [GO:0070050]; one-carbon metabolic process [GO:0006730]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of dipeptide transmembrane transport [GO:2001150]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of chloride transport [GO:2001225]; regulation of intracellular pH [GO:0051453]; regulation of monoatomic anion transport [GO:0044070]; secretion [GO:0046903]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15990874}. Cell membrane {ECO:0000269|PubMed:15990874}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells. {ECO:0000269|PubMed:15990874}.
P00966	reviewed	ASSY_HUMAN	Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)	ASS1 ASS	Homo sapiens (Human)	412	FUNCTION: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. {ECO:0000305|PubMed:18473344, ECO:0000305|PubMed:27287393, ECO:0000305|PubMed:8792870}.		acute-phase response [GO:0006953]; arginine biosynthetic process [GO:0006526]; argininosuccinate metabolic process [GO:0000053]; aspartate metabolic process [GO:0006531]; cellular response to amine stimulus [GO:0071418]; cellular response to amino acid stimulus [GO:0071230]; cellular response to ammonium ion [GO:0071242]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucagon stimulus [GO:0071377]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oleic acid [GO:0071400]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; circadian rhythm [GO:0007623]; citrulline metabolic process [GO:0000052]; diaphragm development [GO:0060539]; kidney development [GO:0001822]; liver development [GO:0001889]; midgut development [GO:0007494]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; response to estradiol [GO:0032355]; response to growth hormone [GO:0060416]; response to mycotoxin [GO:0010046]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; urea cycle [GO:0000050]	cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]	amino acid binding [GO:0016597]; argininosuccinate synthase activity [GO:0004055]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; toxic substance binding [GO:0015643]	cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; amino acid binding [GO:0016597]; argininosuccinate synthase activity [GO:0004055]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; toxic substance binding [GO:0015643]; acute-phase response [GO:0006953]; arginine biosynthetic process [GO:0006526]; argininosuccinate metabolic process [GO:0000053]; aspartate metabolic process [GO:0006531]; cellular response to amine stimulus [GO:0071418]; cellular response to amino acid stimulus [GO:0071230]; cellular response to ammonium ion [GO:0071242]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucagon stimulus [GO:0071377]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oleic acid [GO:0071400]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; circadian rhythm [GO:0007623]; citrulline metabolic process [GO:0000052]; diaphragm development [GO:0060539]; kidney development [GO:0001822]; liver development [GO:0001889]; midgut development [GO:0007494]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; response to estradiol [GO:0032355]; response to growth hormone [GO:0060416]; response to mycotoxin [GO:0010046]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; urea cycle [GO:0000050]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:28985504, ECO:0000305|PubMed:27287393}.
P00973	reviewed	OAS1_HUMAN	2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (E18/E16) (p46/p42 OAS)	OAS1 OIAS	Homo sapiens (Human)	400	FUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:34581622). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:34581622, PubMed:34145065). Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:12799444, ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:23319625, ECO:0000269|PubMed:34145065, ECO:0000269|PubMed:34581622}.; FUNCTION: [Isoform p46]: When prenylated at C-terminal, acts as a double-stranded RNA (dsRNA) sensor specifically targeted to membranous replicative organelles in SARS coronavirus-2/SARS-CoV-2 infected cells where it binds to dsRNA structures in the SARS-CoV-2 5'-UTR and initiates a potent block to SARS-CoV-2 replication. Recognizes short stretches of dsRNA and activates RNase L. The binding is remarkably specific, with two conserved stem loops in the SARS-CoV-2 5'- untranslated region (UTR) constituting the principal viral target (PubMed:34581622). The same mechanism is necessary to initiate a block to cardiovirus EMCV (PubMed:34581622). {ECO:0000269|PubMed:34581622}.; FUNCTION: [Isoform p42]: Not prenylated at C-terminal, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication. {ECO:0000269|PubMed:34581622}.		antiviral innate immune response [GO:0140374]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of IP-10 production [GO:0071659]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; positive regulation of cellular respiration [GO:1901857]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of tumor necrosis factor production [GO:0032760]; protein complex oligomerization [GO:0051259]; regulation of ribonuclease activity [GO:0060700]; response to virus [GO:0009615]; surfactant homeostasis [GO:0043129]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; type I interferon-mediated signaling pathway [GO:0060337]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]	2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]; 2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; antiviral innate immune response [GO:0140374]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of IP-10 production [GO:0071659]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; positive regulation of cellular respiration [GO:1901857]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of tumor necrosis factor production [GO:0032760]; protein complex oligomerization [GO:0051259]; regulation of ribonuclease activity [GO:0060700]; response to virus [GO:0009615]; surfactant homeostasis [GO:0043129]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:3753689, ECO:0000269|PubMed:3754863}. Mitochondrion {ECO:0000269|PubMed:19923450}. Nucleus {ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:3753689}. Microsome {ECO:0000269|PubMed:19923450}. Endoplasmic reticulum {ECO:0000269|PubMed:19923450}. Secreted {ECO:0000250|UniProtKB:Q29599}. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. {ECO:0000269|PubMed:19923450}.; SUBCELLULAR LOCATION: [Isoform p46]: Note=(Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, prenylated form localizes to membranous perinuclear structures reminiscent of the endoplasmic reticulum rich in viral dsRNA which are SARS-CoV-2 replicative organelles. {ECO:0000269|PubMed:34581622}.; SUBCELLULAR LOCATION: [Isoform p42]: Note=(Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, since its not prenylated, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication. {ECO:0000269|PubMed:34581622}.
P00995	reviewed	ISK1_HUMAN	Serine protease inhibitor Kazal-type 1 (Pancreatic secretory trypsin inhibitor) (Tumor-associated trypsin inhibitor) (TATI)	SPINK1 PSTI	Homo sapiens (Human)	79	FUNCTION: Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:7142173). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity). {ECO:0000250|UniProtKB:P09036, ECO:0000269|PubMed:7142173}.; FUNCTION: In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production. {ECO:0000250|UniProtKB:P09036}.		cellular response to peptide hormone stimulus [GO:0071375]; negative regulation of calcium ion import [GO:0090281]; negative regulation of nitric oxide mediated signal transduction [GO:0010751]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of pancreatic juice secretion [GO:0090187]; positive regulation of peptide hormone secretion [GO:0090277]; regulation of acrosome reaction [GO:0060046]; regulation of store-operated calcium entry [GO:2001256]; response to ethanol [GO:0045471]; response to nutrient levels [GO:0031667]; sperm capacitation [GO:0048240]	extracellular exosome [GO:0070062]	endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular exosome [GO:0070062]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; cellular response to peptide hormone stimulus [GO:0071375]; negative regulation of calcium ion import [GO:0090281]; negative regulation of nitric oxide mediated signal transduction [GO:0010751]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of pancreatic juice secretion [GO:0090187]; positive regulation of peptide hormone secretion [GO:0090277]; regulation of acrosome reaction [GO:0060046]; regulation of store-operated calcium entry [GO:2001256]; response to ethanol [GO:0045471]; response to nutrient levels [GO:0031667]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7142173}.
P01008	reviewed	ANT3_HUMAN	Antithrombin-III (ATIII) (Serpin C1)	SERPINC1 AT3 PRO0309	Homo sapiens (Human)	464	FUNCTION: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15853774, PubMed:15140129). AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129). Its inhibitory activity is greatly enhanced in the presence of heparin. {ECO:0000269|PubMed:15140129, ECO:0000269|PubMed:15853774}.		blood coagulation [GO:0007596]; regulation of blood coagulation [GO:0030193]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; blood coagulation [GO:0007596]; regulation of blood coagulation [GO:0030193]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P01009	reviewed	A1AT_HUMAN	Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]	SERPINA1 AAT PI PRO0684 PRO2209	Homo sapiens (Human)	418	FUNCTION: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; FUNCTION: [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).	MISCELLANEOUS: The aberrant form is found in the plasma of chronic smokers, and persists after smoking is ceased. It can still be found ten years after smoking has ceased.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	acute-phase response [GO:0006953]; blood coagulation [GO:0007596]	collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; platelet alpha granule lumen [GO:0031093]	identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]	collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; platelet alpha granule lumen [GO:0031093]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; acute-phase response [GO:0006953]; blood coagulation [GO:0007596]	SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.; SUBCELLULAR LOCATION: [Short peptide from AAT]: Secreted, extracellular space, extracellular matrix.
P01011	reviewed	AACT_HUMAN	Alpha-1-antichymotrypsin (ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3) [Cleaved into: Alpha-1-antichymotrypsin His-Pro-less]	SERPINA3 AACT GIG24 GIG25	Homo sapiens (Human)	423	FUNCTION: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. {ECO:0000269|PubMed:2404007}.	MISCELLANEOUS: Alpha-1-antichymotrypsin can bind DNA.	acute-phase response [GO:0006953]; inflammatory response [GO:0006954]; maintenance of gastrointestinal epithelium [GO:0030277]; regulation of lipid metabolic process [GO:0019216]	azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774]	DNA binding [GO:0003677]; serine-type endopeptidase inhibitor activity [GO:0004867]	azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774]; DNA binding [GO:0003677]; serine-type endopeptidase inhibitor activity [GO:0004867]; acute-phase response [GO:0006953]; inflammatory response [GO:0006954]; maintenance of gastrointestinal epithelium [GO:0030277]; regulation of lipid metabolic process [GO:0019216]	SUBCELLULAR LOCATION: Secreted.
P01019	reviewed	ANGT_HUMAN	Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4]	AGT SERPINA8	Homo sapiens (Human)	485	FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. {ECO:0000269|PubMed:10619573, ECO:0000269|PubMed:1132082, ECO:0000269|PubMed:17138938}.; FUNCTION: [Angiotensin-2]: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (PubMed:10619573, PubMed:17138938). Acts by binding to angiotensin receptors AGTR1 and AGTR2 (PubMed:1567413). Also binds the DEAR/FBXW7-AS1 receptor (By similarity). {ECO:0000250|UniProtKB:P01015, ECO:0000269|PubMed:10619573, ECO:0000269|PubMed:1567413, ECO:0000269|PubMed:17138938}.; FUNCTION: [Angiotensin-3]: Stimulates aldosterone release. {ECO:0000269|PubMed:1132082}.; FUNCTION: [Angiotensin 1-7]: Is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity). {ECO:0000250|UniProtKB:P11859}.		angiotensin-activated signaling pathway [GO:0038166]; blood vessel remodeling [GO:0001974]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [GO:0007199]; kidney development [GO:0001822]; low-density lipoprotein particle remodeling [GO:0034374]; maintenance of blood vessel diameter homeostasis by renin-angiotensin [GO:0002034]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; nitric oxide mediated signal transduction [GO:0007263]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of NAD(P)H oxidase activity [GO:0033864]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transforming growth factor beta1 activation [GO:1901394]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of blood volume by renin-angiotensin [GO:0002016]; regulation of cardiac conduction [GO:1903779]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; regulation of extracellular matrix assembly [GO:1901201]; regulation of renal output by angiotensin [GO:0002019]; regulation of renal sodium excretion [GO:0035813]; regulation of vasoconstriction [GO:0019229]; renal system process [GO:0003014]; renin-angiotensin regulation of aldosterone production [GO:0002018]; response to muscle activity involved in regulation of muscle adaptation [GO:0014873]; vasoconstriction [GO:0042310]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	growth factor activity [GO:0008083]; hormone activity [GO:0005179]; serine-type endopeptidase inhibitor activity [GO:0004867]; type 1 angiotensin receptor binding [GO:0031702]; type 2 angiotensin receptor binding [GO:0031703]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; serine-type endopeptidase inhibitor activity [GO:0004867]; type 1 angiotensin receptor binding [GO:0031702]; type 2 angiotensin receptor binding [GO:0031703]; angiotensin-activated signaling pathway [GO:0038166]; blood vessel remodeling [GO:0001974]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [GO:0007199]; kidney development [GO:0001822]; low-density lipoprotein particle remodeling [GO:0034374]; maintenance of blood vessel diameter homeostasis by renin-angiotensin [GO:0002034]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; nitric oxide mediated signal transduction [GO:0007263]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of NAD(P)H oxidase activity [GO:0033864]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transforming growth factor beta1 activation [GO:1901394]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of blood volume by renin-angiotensin [GO:0002016]; regulation of cardiac conduction [GO:1903779]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; regulation of extracellular matrix assembly [GO:1901201]; regulation of renal output by angiotensin [GO:0002019]; regulation of renal sodium excretion [GO:0035813]; regulation of vasoconstriction [GO:0019229]; renal system process [GO:0003014]; renin-angiotensin regulation of aldosterone production [GO:0002018]; response to muscle activity involved in regulation of muscle adaptation [GO:0014873]; vasoconstriction [GO:0042310]	SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:4300938, ECO:0000305|PubMed:7259779, ECO:0000305|PubMed:7539791}.
P01023	reviewed	A2MG_HUMAN	Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5)	A2M CPAMD5 FWP007	Homo sapiens (Human)	1474	FUNCTION: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.		acute inflammatory response to antigenic stimulus [GO:0002438]; acute-phase response [GO:0006953]; embryonic liver development [GO:1990402]; luteinization [GO:0001553]; negative regulation of complement activation, lectin pathway [GO:0001869]; response to carbon dioxide [GO:0010037]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584]; response to prostaglandin E [GO:0034695]; stem cell differentiation [GO:0048863]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]	brain-derived neurotrophic factor binding [GO:0048403]; calcium-dependent protein binding [GO:0048306]; endopeptidase inhibitor activity [GO:0004866]; enzyme binding [GO:0019899]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-1 binding [GO:0019966]; interleukin-8 binding [GO:0019959]; nerve growth factor binding [GO:0048406]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]; tumor necrosis factor binding [GO:0043120]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; brain-derived neurotrophic factor binding [GO:0048403]; calcium-dependent protein binding [GO:0048306]; endopeptidase inhibitor activity [GO:0004866]; enzyme binding [GO:0019899]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-1 binding [GO:0019966]; interleukin-8 binding [GO:0019959]; nerve growth factor binding [GO:0048406]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]; tumor necrosis factor binding [GO:0043120]; acute inflammatory response to antigenic stimulus [GO:0002438]; acute-phase response [GO:0006953]; embryonic liver development [GO:1990402]; luteinization [GO:0001553]; negative regulation of complement activation, lectin pathway [GO:0001869]; response to carbon dioxide [GO:0010037]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584]; response to prostaglandin E [GO:0034695]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6203908}.
P01024	reviewed	CO3_HUMAN	Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]	C3 CPAMD1	Homo sapiens (Human)	1663	FUNCTION: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.; FUNCTION: Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. {ECO:0000250}.; FUNCTION: [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. {ECO:0000250}.; FUNCTION: [Acylation stimulating protein]: Adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:8376604, PubMed:2909530, PubMed:9059512, PubMed:10432298, PubMed:15833747, PubMed:16333141, PubMed:19615750). {ECO:0000269|PubMed:10432298, ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:16333141, ECO:0000269|PubMed:19615750, ECO:0000269|PubMed:2909530, ECO:0000269|PubMed:8376604, ECO:0000269|PubMed:9059512}.		amyloid-beta clearance [GO:0097242]; cell surface receptor signaling pathway involved in cell-cell signaling [GO:1905114]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; complement-dependent cytotoxicity [GO:0097278]; complement-mediated synapse pruning [GO:0150062]; fatty acid metabolic process [GO:0006631]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; neuron remodeling [GO:0016322]; oviduct epithelium development [GO:0035846]; positive regulation of activation of membrane attack complex [GO:0001970]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of lipid storage [GO:0010884]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of type IIa hypersensitivity [GO:0001798]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of triglyceride biosynthetic process [GO:0010866]; response to bacterium [GO:0009617]; signal transduction [GO:0007165]; vertebrate eye-specific patterning [GO:0150064]	azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]	C5L2 anaphylatoxin chemotactic receptor binding [GO:0031715]; endopeptidase inhibitor activity [GO:0004866]; signaling receptor binding [GO:0005102]	azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; C5L2 anaphylatoxin chemotactic receptor binding [GO:0031715]; endopeptidase inhibitor activity [GO:0004866]; signaling receptor binding [GO:0005102]; amyloid-beta clearance [GO:0097242]; cell surface receptor signaling pathway involved in cell-cell signaling [GO:1905114]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; complement-dependent cytotoxicity [GO:0097278]; complement-mediated synapse pruning [GO:0150062]; fatty acid metabolic process [GO:0006631]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; neuron remodeling [GO:0016322]; oviduct epithelium development [GO:0035846]; positive regulation of activation of membrane attack complex [GO:0001970]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of lipid storage [GO:0010884]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of type IIa hypersensitivity [GO:0001798]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of triglyceride biosynthetic process [GO:0010866]; response to bacterium [GO:0009617]; signal transduction [GO:0007165]; vertebrate eye-specific patterning [GO:0150064]	SUBCELLULAR LOCATION: Secreted.
P01031	reviewed	CO5_HUMAN	Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain]	C5 CPAMD4	Homo sapiens (Human)	1676	FUNCTION: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.; FUNCTION: [C5a anaphylatoxin]: Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. {ECO:0000269|PubMed:8182049}.		cell surface receptor signaling pathway [GO:0007166]; chemotaxis [GO:0006935]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; killing of cells of another organism [GO:0031640]; negative regulation of macrophage chemotaxis [GO:0010760]; positive regulation of chemokine production [GO:0032722]; positive regulation of vascular endothelial growth factor production [GO:0010575]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]	chemokine activity [GO:0008009]; endopeptidase inhibitor activity [GO:0004866]; signaling receptor binding [GO:0005102]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; chemokine activity [GO:0008009]; endopeptidase inhibitor activity [GO:0004866]; signaling receptor binding [GO:0005102]; cell surface receptor signaling pathway [GO:0007166]; chemotaxis [GO:0006935]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; killing of cells of another organism [GO:0031640]; negative regulation of macrophage chemotaxis [GO:0010760]; positive regulation of chemokine production [GO:0032722]; positive regulation of vascular endothelial growth factor production [GO:0010575]	SUBCELLULAR LOCATION: Secreted.
P01033	reviewed	TIMP1_HUMAN	Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)	TIMP1 CLGI TIMP	Homo sapiens (Human)	207	FUNCTION: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. {ECO:0000269|PubMed:1420137, ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:17050530, ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:20545310, ECO:0000269|PubMed:22427646, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540, ECO:0000269|PubMed:8576151, ECO:0000269|PubMed:9065415}.		cartilage development [GO:0051216]; cellular response to UV-A [GO:0071492]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; negative regulation of apoptotic process [GO:0043066]; negative regulation of catalytic activity [GO:0043086]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of metallopeptidase activity [GO:1905049]; negative regulation of trophoblast cell migration [GO:1901164]; positive regulation of cell population proliferation [GO:0008284]; regulation of integrin-mediated signaling pathway [GO:2001044]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; response to peptide hormone [GO:0043434]	basement membrane [GO:0005604]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; metalloendopeptidase inhibitor activity [GO:0008191]; peptidase inhibitor activity [GO:0030414]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]	basement membrane [GO:0005604]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; metalloendopeptidase inhibitor activity [GO:0008191]; peptidase inhibitor activity [GO:0030414]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]; cartilage development [GO:0051216]; cellular response to UV-A [GO:0071492]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; negative regulation of apoptotic process [GO:0043066]; negative regulation of catalytic activity [GO:0043086]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of metallopeptidase activity [GO:1905049]; negative regulation of trophoblast cell migration [GO:1901164]; positive regulation of cell population proliferation [GO:0008284]; regulation of integrin-mediated signaling pathway [GO:2001044]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; response to peptide hormone [GO:0043434]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3010309, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540}.
P01034	reviewed	CYTC_HUMAN	Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin)	CST3	Homo sapiens (Human)	146	FUNCTION: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.	MISCELLANEOUS: Potential cerebrospinal fluid marker for the diagnosis of Creutzfeldt-Jakob disease.	defense response [GO:0006952]; negative regulation of blood vessel remodeling [GO:0060313]; negative regulation of collagen catabolic process [GO:0010711]; negative regulation of elastin catabolic process [GO:0060311]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]; regulation of tissue remodeling [GO:0034103]; supramolecular fiber organization [GO:0097435]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; tertiary granule lumen [GO:1904724]; vesicle [GO:0031982]	amyloid-beta binding [GO:0001540]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; identical protein binding [GO:0042802]; peptidase inhibitor activity [GO:0030414]; protease binding [GO:0002020]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; tertiary granule lumen [GO:1904724]; vesicle [GO:0031982]; amyloid-beta binding [GO:0001540]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; identical protein binding [GO:0042802]; peptidase inhibitor activity [GO:0030414]; protease binding [GO:0002020]; defense response [GO:0006952]; negative regulation of blood vessel remodeling [GO:0060313]; negative regulation of collagen catabolic process [GO:0010711]; negative regulation of elastin catabolic process [GO:0060311]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]; regulation of tissue remodeling [GO:0034103]; supramolecular fiber organization [GO:0097435]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20189825}.
P01036	reviewed	CYTS_HUMAN	Cystatin-S (Cystatin-4) (Cystatin-SA-III) (Salivary acidic protein 1)	CST4	Homo sapiens (Human)	141	FUNCTION: This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively.		detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; negative regulation of proteolysis [GO:0045861]; retina homeostasis [GO:0001895]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; vesicle [GO:0031982]	cysteine-type endopeptidase inhibitor activity [GO:0004869]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; vesicle [GO:0031982]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; negative regulation of proteolysis [GO:0045861]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20189825}.
P01037	reviewed	CYTN_HUMAN	Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1)	CST1	Homo sapiens (Human)	141	FUNCTION: Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.		detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; vesicle [GO:0031982]	cysteine-type endopeptidase inhibitor activity [GO:0004869]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; vesicle [GO:0031982]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20189825}.
P01040	reviewed	CYTA_HUMAN	Cystatin-A (Cystatin-AS) (Stefin-A) [Cleaved into: Cystatin-A, N-terminally processed]	CSTA STF1 STFA	Homo sapiens (Human)	98	FUNCTION: This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. {ECO:0000269|PubMed:21944047}.		cell-cell adhesion [GO:0098609]; keratinocyte differentiation [GO:0030216]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]; peptide cross-linking [GO:0018149]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; peptidase inhibitor complex [GO:1904090]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; protease binding [GO:0002020]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; peptidase inhibitor complex [GO:1904090]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; protease binding [GO:0002020]; cell-cell adhesion [GO:0098609]; keratinocyte differentiation [GO:0030216]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]; peptide cross-linking [GO:0018149]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21944047}.
P01042	reviewed	KNG1_HUMAN	Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor]	KNG1 BDK KNG	Homo sapiens (Human)	644	FUNCTION: Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.; FUNCTION: [Bradykinin]: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action). {ECO:0000305|PubMed:4322742, ECO:0000305|PubMed:6055465}.		blood coagulation [GO:0007596]; inflammatory response [GO:0006954]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cell adhesion [GO:0007162]; negative regulation of proteolysis [GO:0045861]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; vasodilation [GO:0042311]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; heparin binding [GO:0008201]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; zinc ion binding [GO:0008270]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; heparin binding [GO:0008201]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; zinc ion binding [GO:0008270]; blood coagulation [GO:0007596]; inflammatory response [GO:0006954]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cell adhesion [GO:0007162]; negative regulation of proteolysis [GO:0045861]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P01100	reviewed	FOS_HUMAN	Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)	FOS G0S7	Homo sapiens (Human)	380	FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}.		cellular response to cadmium ion [GO:0071276]; cellular response to calcium ion [GO:0071277]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hypoxia [GO:0071456]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to prolactin [GO:1990646]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to zinc ion starvation [GO:0034224]; conditioned taste aversion [GO:0001661]; DNA methylation [GO:0006306]; female pregnancy [GO:0007565]; inflammatory response [GO:0006954]; integrated stress response signaling [GO:0140467]; mononuclear cell differentiation [GO:1903131]; myoblast proliferation [GO:0051450]; nervous system development [GO:0007399]; osteoclast differentiation [GO:0030316]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to activity [GO:0014823]; response to cAMP [GO:0051591]; response to corticosterone [GO:0051412]; response to ethanol [GO:0045471]; response to gravity [GO:0009629]; response to immobilization stress [GO:0035902]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416]; response to lipopolysaccharide [GO:0032496]; response to muscle stretch [GO:0035994]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle cell proliferation [GO:0014856]; SMAD protein signal transduction [GO:0060395]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; cellular response to cadmium ion [GO:0071276]; cellular response to calcium ion [GO:0071277]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hypoxia [GO:0071456]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to prolactin [GO:1990646]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to zinc ion starvation [GO:0034224]; conditioned taste aversion [GO:0001661]; DNA methylation [GO:0006306]; female pregnancy [GO:0007565]; inflammatory response [GO:0006954]; integrated stress response signaling [GO:0140467]; mononuclear cell differentiation [GO:1903131]; myoblast proliferation [GO:0051450]; nervous system development [GO:0007399]; osteoclast differentiation [GO:0030316]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to activity [GO:0014823]; response to cAMP [GO:0051591]; response to corticosterone [GO:0051412]; response to ethanol [GO:0045471]; response to gravity [GO:0009629]; response to immobilization stress [GO:0035902]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416]; response to lipopolysaccharide [GO:0032496]; response to muscle stretch [GO:0035994]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle cell proliferation [GO:0014856]; SMAD protein signal transduction [GO:0060395]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.
P01106	reviewed	MYC_HUMAN	Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)	MYC BHLHE39	Homo sapiens (Human)	454	FUNCTION: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). {ECO:0000250|UniProtKB:P01108, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25956029}.	MISCELLANEOUS: Alternative translation initiation from an upstream, in-frame non-ATG (CTG) codon or a downstream ATG start site results in the production of 2 isoforms with distinct N-termini, shown in this entry as isoforms 2/3 and isoform 1, respectively. {ECO:0000305|PubMed:3277717}.; MISCELLANEOUS: [Isoform 2]: Produced by alternative translation initiation from a CTG codon, which is translated as Met. {ECO:0000305|PubMed:3277717}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative translation initiation from a CTG codon, which is translated as Met, and alternative splicing. {ECO:0000305|PubMed:3277717}.	branching involved in ureteric bud morphogenesis [GO:0001658]; cellular response to hypoxia [GO:0071456]; cellular response to UV [GO:0034644]; cellular response to xenobiotic stimulus [GO:0071466]; chromatin remodeling [GO:0006338]; chromosome organization [GO:0051276]; DNA damage response [GO:0006974]; DNA methylation-dependent heterochromatin formation [GO:0006346]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast apoptotic process [GO:0044346]; G1/S transition of mitotic cell cycle [GO:0000082]; intracellular iron ion homeostasis [GO:0006879]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell division [GO:0051782]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of metanephric cap mesenchymal cell proliferation [GO:0090096]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex disassembly [GO:0032986]; regulation of cell cycle process [GO:0010564]; regulation of gene expression [GO:0010468]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of telomere maintenance [GO:0032204]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gamma radiation [GO:0010332]; response to growth factor [GO:0070848]; response to xenobiotic stimulus [GO:0009410]	chromatin [GO:0000785]; Myc-Max complex [GO:0071943]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription repressor complex [GO:0090571]	core promoter sequence-specific DNA binding [GO:0001046]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SCF ubiquitin ligase complex binding [GO:1905761]; transcription coregulator binding [GO:0001221]; transcription regulator activator activity [GO:0140537]	chromatin [GO:0000785]; Myc-Max complex [GO:0071943]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription repressor complex [GO:0090571]; core promoter sequence-specific DNA binding [GO:0001046]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SCF ubiquitin ligase complex binding [GO:1905761]; transcription coregulator binding [GO:0001221]; transcription regulator activator activity [GO:0140537]; branching involved in ureteric bud morphogenesis [GO:0001658]; cellular response to hypoxia [GO:0071456]; cellular response to UV [GO:0034644]; cellular response to xenobiotic stimulus [GO:0071466]; chromatin remodeling [GO:0006338]; chromosome organization [GO:0051276]; DNA damage response [GO:0006974]; DNA methylation-dependent heterochromatin formation [GO:0006346]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast apoptotic process [GO:0044346]; G1/S transition of mitotic cell cycle [GO:0000082]; intracellular iron ion homeostasis [GO:0006879]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell division [GO:0051782]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of metanephric cap mesenchymal cell proliferation [GO:0090096]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex disassembly [GO:0032986]; regulation of cell cycle process [GO:0010564]; regulation of gene expression [GO:0010468]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of telomere maintenance [GO:0032204]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gamma radiation [GO:0010332]; response to growth factor [GO:0070848]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17558397}. Nucleus, nucleolus {ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:25775507}.
P01111	reviewed	RASN_HUMAN	GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)	NRAS HRAS1	Homo sapiens (Human)	189	FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. {ECO:0000269|PubMed:30712867}.	MISCELLANEOUS: Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors.	MAPK cascade [GO:0000165]; myoblast differentiation [GO:0045445]; positive regulation of endothelial cell proliferation [GO:0001938]; Ras protein signal transduction [GO:0007265]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-containing complex binding [GO:0044877]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-containing complex binding [GO:0044877]; MAPK cascade [GO:0000165]; myoblast differentiation [GO:0045445]; positive regulation of endothelial cell proliferation [GO:0001938]; Ras protein signal transduction [GO:0007265]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}; Lipid-anchor {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}; Cytoplasmic side {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}. Golgi apparatus membrane {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}; Lipid-anchor {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}. Note=Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}.
P01112	reviewed	RASH_HUMAN	GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]	HRAS HRAS1	Homo sapiens (Human)	189	FUNCTION: Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). {ECO:0000269|PubMed:12740440, ECO:0000269|PubMed:14500341, ECO:0000269|PubMed:22821884, ECO:0000269|PubMed:9020151}.		adipose tissue development [GO:0060612]; animal organ morphogenesis [GO:0009887]; cell surface receptor signaling pathway [GO:0007166]; cellular response to gamma radiation [GO:0071480]; cellular senescence [GO:0090398]; chemotaxis [GO:0006935]; defense response to protozoan [GO:0042832]; endocytosis [GO:0006897]; fibroblast proliferation [GO:0048144]; insulin receptor signaling pathway [GO:0008286]; intrinsic apoptotic signaling pathway [GO:0097193]; MAPK cascade [GO:0000165]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of GTPase activity [GO:0034260]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; oncogene-induced cell senescence [GO:0090402]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of GTPase activity [GO:0043547]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of wound healing [GO:0090303]; Ras protein signal transduction [GO:0007265]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; GTPase complex [GO:1905360]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-membrane adaptor activity [GO:0043495]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; GTPase complex [GO:1905360]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-membrane adaptor activity [GO:0043495]; adipose tissue development [GO:0060612]; animal organ morphogenesis [GO:0009887]; cell surface receptor signaling pathway [GO:0007166]; cellular response to gamma radiation [GO:0071480]; cellular senescence [GO:0090398]; chemotaxis [GO:0006935]; defense response to protozoan [GO:0042832]; endocytosis [GO:0006897]; fibroblast proliferation [GO:0048144]; insulin receptor signaling pathway [GO:0008286]; intrinsic apoptotic signaling pathway [GO:0097193]; MAPK cascade [GO:0000165]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of GTPase activity [GO:0034260]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; oncogene-induced cell senescence [GO:0090402]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of GTPase activity [GO:0043547]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of wound healing [GO:0090303]; Ras protein signal transduction [GO:0007265]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with RACK1 to the perinuclear region.
P01116	reviewed	RASK_HUMAN	GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]	KRAS KRAS2 RASK2	Homo sapiens (Human)	189	FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). {ECO:0000269|PubMed:20949621, ECO:0000269|PubMed:22711838, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24623306, ECO:0000305}.		actin cytoskeleton organization [GO:0030036]; endocrine signaling [GO:0038002]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; forebrain astrocyte development [GO:0021897]; glial cell proliferation [GO:0014009]; homeostasis of number of cells within a tissue [GO:0048873]; MAPK cascade [GO:0000165]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rac protein signal transduction [GO:0035022]; Rac protein signal transduction [GO:0016601]; Ras protein signal transduction [GO:0007265]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic transmission, GABAergic [GO:0032228]; skeletal muscle cell differentiation [GO:0035914]; striated muscle cell differentiation [GO:0051146]; type I pneumocyte differentiation [GO:0060509]; visual learning [GO:0008542]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]; actin cytoskeleton organization [GO:0030036]; endocrine signaling [GO:0038002]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; forebrain astrocyte development [GO:0021897]; glial cell proliferation [GO:0014009]; homeostasis of number of cells within a tissue [GO:0048873]; MAPK cascade [GO:0000165]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rac protein signal transduction [GO:0035022]; Rac protein signal transduction [GO:0016601]; Ras protein signal transduction [GO:0007265]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic transmission, GABAergic [GO:0032228]; skeletal muscle cell differentiation [GO:0035914]; striated muscle cell differentiation [GO:0051146]; type I pneumocyte differentiation [GO:0060509]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:29239724}; Lipid-anchor {ECO:0000269|PubMed:29239724, ECO:0000305|PubMed:23698361}; Cytoplasmic side {ECO:0000305|PubMed:23698361}. Endomembrane system {ECO:0000269|PubMed:29239724}. Cytoplasm, cytosol {ECO:0000269|PubMed:23698361}.; SUBCELLULAR LOCATION: [Isoform 2B]: Cell membrane {ECO:0000269|PubMed:28619714}; Lipid-anchor {ECO:0000305|PubMed:28619714}.
P01127	reviewed	PDGFB_HUMAN	Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (Becaplermin)	PDGFB PDGF2 SIS	Homo sapiens (Human)	241	FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250|UniProtKB:P31240, ECO:0000269|PubMed:26599395}.		cell chemotaxis [GO:0060326]; cellular response to growth factor stimulus [GO:0071363]; cellular response to mycophenolic acid [GO:0071506]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; embryonic placenta development [GO:0001892]; gene expression [GO:0010467]; heart development [GO:0007507]; interleukin-18-mediated signaling pathway [GO:0035655]; metanephric glomerular mesangial cell development [GO:0072255]; monocyte chemotaxis [GO:0002548]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of phosphatidylinositol biosynthetic process [GO:0010512]; negative regulation of platelet activation [GO:0010544]; negative regulation of protein binding [GO:0032091]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; paracrine signaling [GO:0038001]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of metanephric mesenchymal cell migration [GO:2000591]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of vascular associated smooth muscle cell dedifferentiation [GO:1905176]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein kinase C signaling [GO:0070528]; protein phosphorylation [GO:0006468]; reactive oxygen species metabolic process [GO:0072593]; response to wounding [GO:0009611]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; platelet alpha granule lumen [GO:0031093]; platelet-derived growth factor complex [GO:1990265]	chemoattractant activity [GO:0042056]; collagen binding [GO:0005518]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; superoxide-generating NADPH oxidase activator activity [GO:0016176]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; platelet alpha granule lumen [GO:0031093]; platelet-derived growth factor complex [GO:1990265]; chemoattractant activity [GO:0042056]; collagen binding [GO:0005518]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; cell chemotaxis [GO:0060326]; cellular response to growth factor stimulus [GO:0071363]; cellular response to mycophenolic acid [GO:0071506]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; embryonic placenta development [GO:0001892]; gene expression [GO:0010467]; heart development [GO:0007507]; interleukin-18-mediated signaling pathway [GO:0035655]; metanephric glomerular mesangial cell development [GO:0072255]; monocyte chemotaxis [GO:0002548]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of phosphatidylinositol biosynthetic process [GO:0010512]; negative regulation of platelet activation [GO:0010544]; negative regulation of protein binding [GO:0032091]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; paracrine signaling [GO:0038001]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of metanephric mesenchymal cell migration [GO:2000591]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of vascular associated smooth muscle cell dedifferentiation [GO:1905176]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein kinase C signaling [GO:0070528]; protein phosphorylation [GO:0006468]; reactive oxygen species metabolic process [GO:0072593]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Secreted. Note=Released by platelets upon wounding.
P01130	reviewed	LDLR_HUMAN	Low-density lipoprotein receptor (LDL receptor)	LDLR	Homo sapiens (Human)	860	FUNCTION: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. {ECO:0000269|PubMed:3005267, ECO:0000269|PubMed:6091915}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. {ECO:0000269|PubMed:10535997, ECO:0000269|PubMed:12615904}.; FUNCTION: (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. {ECO:0000269|PubMed:23589850}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. {ECO:0000269|PubMed:11100124}.		amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; artery morphogenesis [GO:0048844]; cellular response to fatty acid [GO:0071398]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; high-density lipoprotein particle clearance [GO:0034384]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; long-term memory [GO:0007616]; low-density lipoprotein particle clearance [GO:0034383]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of astrocyte activation [GO:0061889]; negative regulation of gene expression [GO:0010629]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of receptor recycling [GO:0001920]; phagocytosis [GO:0006909]; phospholipid transport [GO:0015914]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of triglyceride biosynthetic process [GO:0010867]; receptor-mediated endocytosis [GO:0006898]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; regulation of cholesterol metabolic process [GO:0090181]; regulation of phosphatidylcholine catabolic process [GO:0010899]; regulation of protein metabolic process [GO:0051246]; response to caloric restriction [GO:0061771]	apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; low-density lipoprotein particle [GO:0034362]; lysosome [GO:0005764]; membrane [GO:0016020]; PCSK9-LDLR complex [GO:1990666]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; somatodendritic compartment [GO:0036477]; sorting endosome [GO:0097443]	amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; clathrin heavy chain binding [GO:0032050]; identical protein binding [GO:0042802]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; molecular adaptor activity [GO:0060090]; protease binding [GO:0002020]; very-low-density lipoprotein particle receptor activity [GO:0030229]; virus receptor activity [GO:0001618]	apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; low-density lipoprotein particle [GO:0034362]; lysosome [GO:0005764]; membrane [GO:0016020]; PCSK9-LDLR complex [GO:1990666]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; somatodendritic compartment [GO:0036477]; sorting endosome [GO:0097443]; amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; clathrin heavy chain binding [GO:0032050]; identical protein binding [GO:0042802]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; molecular adaptor activity [GO:0060090]; protease binding [GO:0002020]; very-low-density lipoprotein particle receptor activity [GO:0030229]; virus receptor activity [GO:0001618]; amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; artery morphogenesis [GO:0048844]; cellular response to fatty acid [GO:0071398]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; high-density lipoprotein particle clearance [GO:0034384]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; long-term memory [GO:0007616]; low-density lipoprotein particle clearance [GO:0034383]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of astrocyte activation [GO:0061889]; negative regulation of gene expression [GO:0010629]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of receptor recycling [GO:0001920]; phagocytosis [GO:0006909]; phospholipid transport [GO:0015914]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of triglyceride biosynthetic process [GO:0010867]; receptor-mediated endocytosis [GO:0006898]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; regulation of cholesterol metabolic process [GO:0090181]; regulation of phosphatidylcholine catabolic process [GO:0010899]; regulation of protein metabolic process [GO:0051246]; response to caloric restriction [GO:0061771]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17461796, ECO:0000269|PubMed:19520913}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P01131}. Membrane, clathrin-coated pit {ECO:0000303|PubMed:6091915}. Golgi apparatus {ECO:0000269|PubMed:17461796}. Early endosome {ECO:0000269|PubMed:17461796}. Late endosome {ECO:0000269|PubMed:17461796}. Lysosome {ECO:0000269|PubMed:17461796}. Note=Rapidly endocytosed upon ligand binding. {ECO:0000269|PubMed:3104336}.
P01133	reviewed	EGF_HUMAN	Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor (Urogastrone)]	EGF	Homo sapiens (Human)	1207	FUNCTION: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941). {ECO:0000269|PubMed:10964941, ECO:0000269|PubMed:17671655}.		angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; cerebellar granule cell precursor proliferation [GO:0021930]; epidermal growth factor receptor signaling pathway [GO:0007173]; epidermal growth factor receptor signaling pathway via MAPK cascade [GO:0038029]; epithelial cell proliferation [GO:0050673]; ERBB2-EGFR signaling pathway [GO:0038134]; ERK1 and ERK2 cascade [GO:0070371]; mammary gland alveolus development [GO:0060749]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of secretion [GO:0051048]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cerebellar granule cell precursor proliferation [GO:0021940]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of receptor internalization [GO:0002092]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; regulation of calcium ion import [GO:0090279]; regulation of protein localization to cell surface [GO:2000008]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	clathrin-coated endocytic vesicle membrane [GO:0030669]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]	calcium ion binding [GO:0005509]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; guanyl-nucleotide exchange factor activity [GO:0005085]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	clathrin-coated endocytic vesicle membrane [GO:0030669]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; calcium ion binding [GO:0005509]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; guanyl-nucleotide exchange factor activity [GO:0005085]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; cerebellar granule cell precursor proliferation [GO:0021930]; epidermal growth factor receptor signaling pathway [GO:0007173]; epidermal growth factor receptor signaling pathway via MAPK cascade [GO:0038029]; epithelial cell proliferation [GO:0050673]; ERBB2-EGFR signaling pathway [GO:0038134]; ERK1 and ERK2 cascade [GO:0070371]; mammary gland alveolus development [GO:0060749]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of secretion [GO:0051048]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cerebellar granule cell precursor proliferation [GO:0021940]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of receptor internalization [GO:0002092]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; regulation of calcium ion import [GO:0090279]; regulation of protein localization to cell surface [GO:2000008]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P01135	reviewed	TGFA_HUMAN	Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1)]	TGFA	Homo sapiens (Human)	160	FUNCTION: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.		angiogenesis [GO:0001525]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2-EGFR signaling pathway [GO:0038134]; hepatocyte proliferation [GO:0072574]; intracellular signal transduction [GO:0035556]; mammary gland alveolus development [GO:0060749]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; angiogenesis [GO:0001525]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2-EGFR signaling pathway [GO:0038134]; hepatocyte proliferation [GO:0072574]; intracellular signal transduction [GO:0035556]; mammary gland alveolus development [GO:0060749]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]	SUBCELLULAR LOCATION: [Transforming growth factor alpha]: Secreted, extracellular space.; SUBCELLULAR LOCATION: [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.
P01137	reviewed	TGFB1_HUMAN	Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]	TGFB1 TGFB	Homo sapiens (Human)	390	FUNCTION: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. {ECO:0000269|PubMed:29109152, ECO:0000303|PubMed:27252363}.; FUNCTION: [Latency-associated peptide]: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix (PubMed:28117447). Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1 (PubMed:2022183, PubMed:8617200, PubMed:8939931, PubMed:19750484, PubMed:22278742, PubMed:19651619). Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia (Probable). Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:22278742, PubMed:19651619). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1 (PubMed:22278742, PubMed:28117447). {ECO:0000269|PubMed:19651619, ECO:0000269|PubMed:19750484, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:28117447, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931, ECO:0000305|PubMed:29909984}.; FUNCTION: [Transforming growth factor beta-1]: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix (PubMed:29109152). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus (PubMed:2022183, PubMed:8617200, PubMed:8939931, PubMed:19750484, PubMed:22278742, PubMed:19651619). TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1 (PubMed:22278742, PubMed:28117447). Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (PubMed:20207738). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules' (By similarity). Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner (By similarity). At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development (By similarity). At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292, PubMed:29483653, PubMed:30696809). Positively regulates odontoblastic differentiation in dental papilla cells, via promotion of IPO7-mediated translocation of phosphorylated SMAD2 to the nucleus and subsequent transcription of target genes (By similarity). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292, PubMed:30696809). {ECO:0000250|UniProtKB:P04202, ECO:0000269|PubMed:19651619, ECO:0000269|PubMed:19750484, ECO:0000269|PubMed:20207738, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:25310401, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:28117447, ECO:0000269|PubMed:29109152, ECO:0000269|PubMed:29483653, ECO:0000269|PubMed:30696809, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}.	MISCELLANEOUS: TGF-beta-1 is inactivated by fresolimumab (also named GC1008), a monoclonal-neutralizing antibody. {ECO:0000269|PubMed:25209176}.	aortic valve morphogenesis [GO:0003180]; ATP biosynthetic process [GO:0006754]; cell-cell junction organization [GO:0045216]; cellular response to hypoxia [GO:0071456]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte differentiation [GO:0002062]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; embryonic liver development [GO:1990402]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial to mesenchymal transition [GO:0001837]; extracellular matrix assembly [GO:0085029]; extrinsic apoptotic signaling pathway [GO:0097191]; heart development [GO:0007507]; heart valve morphogenesis [GO:0003179]; hematopoietic progenitor cell differentiation [GO:0002244]; hyaluronan catabolic process [GO:0030214]; lymph node development [GO:0048535]; macrophage derived foam cell differentiation [GO:0010742]; membrane protein intracellular domain proteolysis [GO:0031293]; myofibroblast differentiation [GO:0036446]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of skeletal muscle tissue development [GO:0048642]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; odontoblast differentiation [GO:0071895]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemotaxis [GO:0050921]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of microglia differentiation [GO:0014008]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NAD+ ADP-ribosyltransferase activity [GO:1901666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of primary miRNA processing [GO:2000636]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular permeability [GO:0043117]; protein export from nucleus [GO:0006611]; receptor catabolic process [GO:0032801]; regulation of blood vessel remodeling [GO:0060312]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of protein import into nucleus [GO:0042306]; regulation of SMAD protein signal transduction [GO:0060390]; regulation of striated muscle tissue development [GO:0016202]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulatory T cell differentiation [GO:0045066]; response to cholesterol [GO:0070723]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; salivary gland morphogenesis [GO:0007435]; selective autophagy [GO:0061912]; sprouting angiogenesis [GO:0002040]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]	antigen binding [GO:0003823]; cytokine activity [GO:0005125]; deubiquitinase activator activity [GO:0035800]; enzyme binding [GO:0019899]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; antigen binding [GO:0003823]; cytokine activity [GO:0005125]; deubiquitinase activator activity [GO:0035800]; enzyme binding [GO:0019899]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714]; aortic valve morphogenesis [GO:0003180]; ATP biosynthetic process [GO:0006754]; cell-cell junction organization [GO:0045216]; cellular response to hypoxia [GO:0071456]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte differentiation [GO:0002062]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; embryonic liver development [GO:1990402]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial to mesenchymal transition [GO:0001837]; extracellular matrix assembly [GO:0085029]; extrinsic apoptotic signaling pathway [GO:0097191]; heart development [GO:0007507]; heart valve morphogenesis [GO:0003179]; hematopoietic progenitor cell differentiation [GO:0002244]; hyaluronan catabolic process [GO:0030214]; lymph node development [GO:0048535]; macrophage derived foam cell differentiation [GO:0010742]; membrane protein intracellular domain proteolysis [GO:0031293]; myofibroblast differentiation [GO:0036446]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of skeletal muscle tissue development [GO:0048642]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; odontoblast differentiation [GO:0071895]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemotaxis [GO:0050921]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of microglia differentiation [GO:0014008]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NAD+ ADP-ribosyltransferase activity [GO:1901666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of primary miRNA processing [GO:2000636]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular permeability [GO:0043117]; protein export from nucleus [GO:0006611]; receptor catabolic process [GO:0032801]; regulation of blood vessel remodeling [GO:0060312]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of protein import into nucleus [GO:0042306]; regulation of SMAD protein signal transduction [GO:0060390]; regulation of striated muscle tissue development [GO:0016202]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulatory T cell differentiation [GO:0045066]; response to cholesterol [GO:0070723]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; salivary gland morphogenesis [GO:0007435]; selective autophagy [GO:0061912]; sprouting angiogenesis [GO:0002040]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	SUBCELLULAR LOCATION: [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17827158}.; SUBCELLULAR LOCATION: [Transforming growth factor beta-1]: Secreted {ECO:0000269|PubMed:17827158, ECO:0000269|PubMed:29483653}.
P01138	reviewed	NGF_HUMAN	Beta-nerve growth factor (Beta-NGF)	NGF NGFB	Homo sapiens (Human)	241	FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:20978020) (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity). {ECO:0000250|UniProtKB:P01139, ECO:0000269|PubMed:14976160, ECO:0000269|PubMed:20164177, ECO:0000269|PubMed:20978020, ECO:0000305|PubMed:10490030, ECO:0000305|PubMed:15131306}.		extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; memory [GO:0007613]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; neuron projection morphogenesis [GO:0048812]; peripheral nervous system development [GO:0007422]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of neuron differentiation [GO:0045664]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; synaptic vesicle [GO:0008021]	growth factor activity [GO:0008083]; lipid binding [GO:0008289]; metalloendopeptidase inhibitor activity [GO:0008191]; nerve growth factor receptor binding [GO:0005163]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; synaptic vesicle [GO:0008021]; growth factor activity [GO:0008083]; lipid binding [GO:0008289]; metalloendopeptidase inhibitor activity [GO:0008191]; nerve growth factor receptor binding [GO:0005163]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; memory [GO:0007613]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; neuron projection morphogenesis [GO:0048812]; peripheral nervous system development [GO:0007422]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of neuron differentiation [GO:0045664]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20978020}. Endosome lumen {ECO:0000250|UniProtKB:P01139}. Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR. {ECO:0000250|UniProtKB:P01139}.
P01148	reviewed	GON1_HUMAN	Progonadoliberin-1 (Progonadoliberin I) [Cleaved into: Gonadoliberin-1 (Gonadoliberin I) (Gonadorelin) (Gonadotropin-releasing hormone I) (GnRH-I) (Luliberin I) (Luteinizing hormone-releasing hormone I) (LH-RH I); GnRH-associated peptide 1 (GnRH-associated peptide I)]	GNRH1 GNRH GRH LHRH	Homo sapiens (Human)	92	FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.	MISCELLANEOUS: The 3D-structure was determined for the synthetic analog Triptorelin. {ECO:0000269|PubMed:26190377}.	cell-cell signaling [GO:0007267]; negative regulation of neuron migration [GO:2001223]; regulation of gene expression [GO:0010468]; regulation of ovarian follicle development [GO:2000354]; reproduction [GO:0000003]; response to ethanol [GO:0045471]; response to steroid hormone [GO:0048545]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	gonadotropin hormone-releasing hormone activity [GO:0005183]; gonadotropin-releasing hormone receptor binding [GO:0031530]; hormone activity [GO:0005179]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; gonadotropin hormone-releasing hormone activity [GO:0005183]; gonadotropin-releasing hormone receptor binding [GO:0031530]; hormone activity [GO:0005179]; cell-cell signaling [GO:0007267]; negative regulation of neuron migration [GO:2001223]; regulation of gene expression [GO:0010468]; regulation of ovarian follicle development [GO:2000354]; reproduction [GO:0000003]; response to ethanol [GO:0045471]; response to steroid hormone [GO:0048545]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P01160	reviewed	ANF_HUMAN	Natriuretic peptides A (Atrial natriuretic factor prohormone) (proANF) (Atrial natriuretic peptide prohormone) (preproANP) (proANP) (Atriopeptigen) (Cardiodilatin) (CDD) (preproCDD-ANF) [Cleaved into: Long-acting natriuretic peptide (LANP) (Long-acting natriuretic hormone) (LANH) (Pro atrial natriuretic factor 1-30) (proANF 1-30) (Pro atrial natriuretic peptide 1-30) (proANP 1-30); Vessel dilator (VSDL) (Pro atrial natriuretic factor 31-67) (proANF 31-67) (Pro atrial natriuretic peptide 31-67) (proANP 31-67); Kaliuretic peptide (KP) (Pro atrial natriuretic factor 79-98) (proANF 79-98) (Pro atrial natriuretic peptide 79-98) (proANP 79-98); Urodilatin (URO) (CDD 95-126) (CDD-ANP (95-126)) (Pro atrial natriuretic peptide 95-126) (proANP 95-126); Auriculin-C (Atrial natriuretic factor 1-33) (ANF 1-33); Auriculin-D (Atrial natriuretic factor 3-33) (ANF 3-33); Atrial natriuretic peptide (ANP) (Alpha-atrial natriuretic peptide) (Alpha-hANP) (Atrial natriuretic factor) (ANF) (CDD-ANF) (CDD-ANP (99-126)) (Cardionatrin) (Pro atrial natriuretic factor 99-126) (proANF 99-126); Auriculin-B (Atrial natriuretic factor 8-33) (ANF 8-33); Auriculin-A; Atriopeptin-1 (Atriopeptin I); Atriopeptin-2 (Atriopeptin II); Atriopeptin-3 (Atriopeptin III)]	NPPA ANP PND	Homo sapiens (Human)	151	FUNCTION: [Atrial natriuretic peptide]: Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (PubMed:8653797, PubMed:7595132, PubMed:2825692, PubMed:7720651, PubMed:8087923, PubMed:2532366, PubMed:22307324, PubMed:18835931, PubMed:21672517, PubMed:15741263, PubMed:16875975). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (PubMed:25401746, PubMed:9893117, PubMed:1672777, PubMed:1660465, PubMed:2162527, PubMed:2825692, PubMed:7720651, PubMed:22307324, PubMed:8384600, PubMed:21098034). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (PubMed:8653797, PubMed:7595132, PubMed:2825692, PubMed:7720651, PubMed:2532366, PubMed:8087923). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (PubMed:16875975). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (PubMed:22307324, PubMed:18835931, PubMed:21672517, PubMed:15741263). This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (PubMed:22307324, PubMed:18835931, PubMed:21672517, PubMed:15741263). Binds the clearance receptor NPR3 which removes the hormone from circulation (PubMed:1672777). {ECO:0000250|UniProtKB:P05125, ECO:0000269|PubMed:15741263, ECO:0000269|PubMed:1660465, ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:16875975, ECO:0000269|PubMed:18835931, ECO:0000269|PubMed:21098034, ECO:0000269|PubMed:2162527, ECO:0000269|PubMed:21672517, ECO:0000269|PubMed:22307324, ECO:0000269|PubMed:2532366, ECO:0000269|PubMed:25401746, ECO:0000269|PubMed:2825692, ECO:0000269|PubMed:7595132, ECO:0000269|PubMed:7720651, ECO:0000269|PubMed:8087923, ECO:0000269|PubMed:8384600, ECO:0000269|PubMed:8653797, ECO:0000269|PubMed:9893117}.; FUNCTION: [Long-acting natriuretic peptide]: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis (PubMed:8653797, PubMed:7955907, PubMed:8087923, PubMed:2825692, PubMed:7595132, PubMed:2532366). In vitro, promotes the production of cGMP and induces vasodilation (PubMed:2825692). May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (PubMed:7720651). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator (PubMed:2162527, PubMed:2825692). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (PubMed:11145122). {ECO:0000250|UniProtKB:P01161, ECO:0000269|PubMed:11145122, ECO:0000269|PubMed:2162527, ECO:0000269|PubMed:2532366, ECO:0000269|PubMed:2825692, ECO:0000269|PubMed:7595132, ECO:0000269|PubMed:7720651, ECO:0000269|PubMed:7955907, ECO:0000269|PubMed:8087923, ECO:0000269|PubMed:8653797}.; FUNCTION: [Vessel dilator]: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation (PubMed:8653797, PubMed:7955907, PubMed:8087923, PubMed:2532366, PubMed:7595132). In vitro, promotes the production of cGMP and induces vasodilation (PubMed:2825692). May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (PubMed:7720651, PubMed:7595132). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (PubMed:7831500). Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides (PubMed:2162527, PubMed:2825692). Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption (PubMed:11145122). {ECO:0000269|PubMed:11145122, ECO:0000269|PubMed:2162527, ECO:0000269|PubMed:2532366, ECO:0000269|PubMed:2825692, ECO:0000269|PubMed:7595132, ECO:0000269|PubMed:7720651, ECO:0000269|PubMed:7831500, ECO:0000269|PubMed:7955907, ECO:0000269|PubMed:8087923, ECO:0000269|PubMed:8653797}.; FUNCTION: [Kaliuretic peptide]: May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis (PubMed:8087923, PubMed:2825692, PubMed:7595132). In vitro, promotes the production of cGMP and induces vasodilation (PubMed:2825692). May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (PubMed:7720651, PubMed:7595132). May have a role in potassium excretion but not sodium excretion (natriuresis) (PubMed:8087923). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (PubMed:11145122). {ECO:0000269|PubMed:11145122, ECO:0000269|PubMed:2825692, ECO:0000269|PubMed:7595132, ECO:0000269|PubMed:7720651, ECO:0000269|PubMed:8087923}.; FUNCTION: [Urodilatin]: Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis (PubMed:8351194, PubMed:8853410, PubMed:8779891). Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance (PubMed:2528951, PubMed:8351194, PubMed:8853410, PubMed:8779891). Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1 (PubMed:8384600, PubMed:9893117). Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney (PubMed:8779891, PubMed:8384600). {ECO:0000269|PubMed:2528951, ECO:0000269|PubMed:8351194, ECO:0000269|PubMed:8384600, ECO:0000269|PubMed:8779891, ECO:0000269|PubMed:8853410, ECO:0000269|PubMed:9893117}.; FUNCTION: [Auriculin-D]: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips. {ECO:0000250|UniProtKB:P01161}.; FUNCTION: [Auriculin-B]: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips. {ECO:0000250|UniProtKB:P01161}.; FUNCTION: [Auriculin-A]: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips. {ECO:0000250|UniProtKB:P01161}.; FUNCTION: [Atriopeptin-2]: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips. {ECO:0000250|UniProtKB:P01161}.; FUNCTION: [Atriopeptin-1]: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips. {ECO:0000250|UniProtKB:P01161}.		aortic valve morphogenesis [GO:0003180]; cardiac conduction system development [GO:0003161]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; female pregnancy [GO:0007565]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of heart rate [GO:0010460]; positive regulation of potassium ion export across plasma membrane [GO:1903766]; protein folding [GO:0006457]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of blood pressure [GO:0008217]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of high voltage-gated calcium channel activity [GO:1901841]; response to muscle stretch [GO:0035994]; sodium ion export across plasma membrane [GO:0036376]; vasodilation [GO:0042311]	cell projection [GO:0042995]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]	hormone activity [GO:0005179]; hormone receptor binding [GO:0051427]; neuropeptide hormone activity [GO:0005184]; neuropeptide receptor binding [GO:0071855]; signaling receptor binding [GO:0005102]	cell projection [GO:0042995]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]; hormone activity [GO:0005179]; hormone receptor binding [GO:0051427]; neuropeptide hormone activity [GO:0005184]; neuropeptide receptor binding [GO:0071855]; signaling receptor binding [GO:0005102]; aortic valve morphogenesis [GO:0003180]; cardiac conduction system development [GO:0003161]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; female pregnancy [GO:0007565]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of heart rate [GO:0010460]; positive regulation of potassium ion export across plasma membrane [GO:1903766]; protein folding [GO:0006457]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of blood pressure [GO:0008217]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of high voltage-gated calcium channel activity [GO:1901841]; response to muscle stretch [GO:0035994]; sodium ion export across plasma membrane [GO:0036376]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: [Long-acting natriuretic peptide]: Secreted {ECO:0000269|PubMed:2532366, ECO:0000269|PubMed:7955907, ECO:0000269|PubMed:7984506, ECO:0000269|PubMed:8653797}. Note=Detected in blood. {ECO:0000269|PubMed:2532366, ECO:0000269|PubMed:7955907, ECO:0000269|PubMed:7984506, ECO:0000269|PubMed:8653797}.; SUBCELLULAR LOCATION: [Vessel dilator]: Secreted {ECO:0000269|PubMed:2532366, ECO:0000269|PubMed:7955907, ECO:0000269|PubMed:7984506, ECO:0000269|PubMed:8653797}. Note=Detected in blood. {ECO:0000269|PubMed:2532366, ECO:0000269|PubMed:7955907, ECO:0000269|PubMed:7984506, ECO:0000269|PubMed:8653797}.; SUBCELLULAR LOCATION: [Kaliuretic peptide]: Secreted {ECO:0000269|PubMed:7984506}. Note=Detected in blood. {ECO:0000269|PubMed:7984506}.; SUBCELLULAR LOCATION: [Urodilatin]: Secreted {ECO:0000269|PubMed:2972874, ECO:0000269|PubMed:8351194, ECO:0000269|PubMed:8779891, ECO:0000269|PubMed:8853410, ECO:0000269|PubMed:9794555, ECO:0000269|PubMed:9893117}. Note=Detected in urine (PubMed:2972874, PubMed:9794555, PubMed:8351194, PubMed:8779891). Not detected in blood (PubMed:8351194). Increased electrolytes, osmolality and intracellular cAMP levels increase peptide secretion/excretion (PubMed:9893117, PubMed:8853410, PubMed:8351194, PubMed:8779891). {ECO:0000269|PubMed:2972874, ECO:0000269|PubMed:8351194, ECO:0000269|PubMed:8779891, ECO:0000269|PubMed:8853410, ECO:0000269|PubMed:9794555, ECO:0000269|PubMed:9893117}.; SUBCELLULAR LOCATION: [Atrial natriuretic peptide]: Secreted {ECO:0000269|PubMed:15741263, ECO:0000269|PubMed:18835931, ECO:0000269|PubMed:2532366, ECO:0000269|PubMed:2972874, ECO:0000269|PubMed:7955907, ECO:0000269|PubMed:7984506, ECO:0000269|PubMed:8351194, ECO:0000269|PubMed:8653797, ECO:0000269|PubMed:8779891, ECO:0000269|PubMed:9893117}. Perikaryon {ECO:0000269|PubMed:30534047}. Cell projection {ECO:0000269|PubMed:30534047}. Note=Detected in blood (PubMed:8351194, PubMed:8779891, PubMed:7955907, PubMed:8653797, PubMed:15741263, PubMed:18835931, PubMed:2532366, PubMed:7984506). Detected in urine in one study (PubMed:8351194). However, in another study, was not detected in urine (PubMed:7984506). Detected in cytoplasmic bodies and neuronal processes of pyramidal neurons (layers II-VI) (PubMed:30534047). Increased secretion in response to the vasopressin AVP (By similarity). Likely to be secreted in response to an increase in atrial pressure or atrial stretch (PubMed:2532366). In kidney cells, secretion increases in response to activated guanylyl cyclases and increased intracellular cAMP levels (PubMed:9893117). Plasma levels increase 15 minutes after a high-salt meal, and decrease back to normal plasma levels 1 hr later (PubMed:8779891). {ECO:0000250|UniProtKB:P01161, ECO:0000269|PubMed:15741263, ECO:0000269|PubMed:18835931, ECO:0000269|PubMed:2532366, ECO:0000269|PubMed:30534047, ECO:0000269|PubMed:7955907, ECO:0000269|PubMed:7984506, ECO:0000269|PubMed:8351194, ECO:0000269|PubMed:8653797, ECO:0000269|PubMed:8779891, ECO:0000269|PubMed:9893117}.; SUBCELLULAR LOCATION: [Atriopeptin-3]: Secreted {ECO:0000250|UniProtKB:P01161}. Note=Detected in blood. Slight increase in secretion in response to the vasopressin AVP. {ECO:0000250|UniProtKB:P01161}.
P01178	reviewed	NEU1_HUMAN	Oxytocin-neurophysin 1 (OT-NPI) [Cleaved into: Oxytocin (Ocytocin); Neurophysin 1]	OXT OT	Homo sapiens (Human)	125	FUNCTION: Neurophysin 1 specifically binds oxytocin.; FUNCTION: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed:18174156). {ECO:0000269|PubMed:18174156}.		positive regulation of cold-induced thermogenesis [GO:0120162]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]	neurohypophyseal hormone activity [GO:0005185]; neuropeptide hormone activity [GO:0005184]; oxytocin receptor binding [GO:0031855]; V1A vasopressin receptor binding [GO:0031894]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; neurohypophyseal hormone activity [GO:0005185]; neuropeptide hormone activity [GO:0005184]; oxytocin receptor binding [GO:0031855]; V1A vasopressin receptor binding [GO:0031894]; positive regulation of cold-induced thermogenesis [GO:0120162]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P01185	reviewed	NEU2_HUMAN	Vasopressin-neurophysin 2-copeptin (AVP-NPII) [Cleaved into: Arg-vasopressin (Arginine-vasopressin); Neurophysin 2 (Neurophysin-II); Copeptin]	AVP ARVP VP	Homo sapiens (Human)	164	FUNCTION: [Neurophysin 2]: Specifically binds vasopressin.; FUNCTION: [Arg-vasopressin]: Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (PubMed:18174156). {ECO:0000269|PubMed:18174156}.		cell-cell signaling [GO:0007267]; ERK1 and ERK2 cascade [GO:0070371]; generation of precursor metabolites and energy [GO:0006091]; grooming behavior [GO:0007625]; locomotory behavior [GO:0007626]; maternal aggressive behavior [GO:0002125]; maternal behavior [GO:0042711]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of female receptivity [GO:0007621]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of transmission of nerve impulse [GO:0051970]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; protein kinase C signaling [GO:0070528]; response to ethanol [GO:0045471]; response to nicotine [GO:0035094]; response to testosterone [GO:0033574]; signal transduction [GO:0007165]; social behavior [GO:0035176]; vasoconstriction [GO:0042310]; viral entry into host cell [GO:0046718]; water transport [GO:0006833]	clathrin-coated endocytic vesicle membrane [GO:0030669]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; secretory granule [GO:0030141]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; neurohypophyseal hormone activity [GO:0005185]; neuropeptide hormone activity [GO:0005184]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102]; V1A vasopressin receptor binding [GO:0031894]; V1B vasopressin receptor binding [GO:0031895]	clathrin-coated endocytic vesicle membrane [GO:0030669]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; secretory granule [GO:0030141]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; neurohypophyseal hormone activity [GO:0005185]; neuropeptide hormone activity [GO:0005184]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102]; V1A vasopressin receptor binding [GO:0031894]; V1B vasopressin receptor binding [GO:0031895]; cell-cell signaling [GO:0007267]; ERK1 and ERK2 cascade [GO:0070371]; generation of precursor metabolites and energy [GO:0006091]; grooming behavior [GO:0007625]; locomotory behavior [GO:0007626]; maternal aggressive behavior [GO:0002125]; maternal behavior [GO:0042711]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of female receptivity [GO:0007621]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of transmission of nerve impulse [GO:0051970]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; protein kinase C signaling [GO:0070528]; response to ethanol [GO:0045471]; response to nicotine [GO:0035094]; response to testosterone [GO:0033574]; signal transduction [GO:0007165]; social behavior [GO:0035176]; vasoconstriction [GO:0042310]; viral entry into host cell [GO:0046718]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Secreted.
P01189	reviewed	COLI_HUMAN	Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]	POMC	Homo sapiens (Human)	267	FUNCTION: [Corticotropin]: Stimulates the adrenal glands to release cortisol.; FUNCTION: [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; FUNCTION: [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes.; FUNCTION: [Beta-endorphin]: Endogenous orexigenic opiate.; FUNCTION: [Met-enkephalin]: Endogenous opiate.		calcium-mediated signaling [GO:0019722]; cell-cell signaling [GO:0007267]; cellular pigmentation [GO:0033059]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; negative regulation of tumor necrosis factor production [GO:0032720]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of oxytocin production [GO:0140668]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of appetite [GO:0032098]; regulation of blood pressure [GO:0008217]; regulation of corticosterone secretion [GO:2000852]; regulation of glycogen metabolic process [GO:0070873]; response to melanocyte-stimulating hormone [GO:1990680]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; secretory granule lumen [GO:0034774]	G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; type 1 melanocortin receptor binding [GO:0070996]; type 3 melanocortin receptor binding [GO:0031781]; type 4 melanocortin receptor binding [GO:0031782]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; secretory granule lumen [GO:0034774]; G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; type 1 melanocortin receptor binding [GO:0070996]; type 3 melanocortin receptor binding [GO:0031781]; type 4 melanocortin receptor binding [GO:0031782]; calcium-mediated signaling [GO:0019722]; cell-cell signaling [GO:0007267]; cellular pigmentation [GO:0033059]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; negative regulation of tumor necrosis factor production [GO:0032720]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of oxytocin production [GO:0140668]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of appetite [GO:0032098]; regulation of blood pressure [GO:0008217]; regulation of corticosterone secretion [GO:2000852]; regulation of glycogen metabolic process [GO:0070873]; response to melanocyte-stimulating hormone [GO:1990680]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}. Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
P01210	reviewed	PENK_HUMAN	Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(114-133); PENK(143-183); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(237-258); Met-enkephalin-Arg-Phe]	PENK	Homo sapiens (Human)	267	FUNCTION: [Met-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. {ECO:0000269|PubMed:7057924}.; FUNCTION: [Leu-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. {ECO:0000269|PubMed:7057924}.; FUNCTION: [Met-enkephalin-Arg-Phe]: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release. {ECO:0000250|UniProtKB:P22005}.; FUNCTION: [PENK(114-133)]: Increases glutamate release in the striatum and decreases GABA concentration in the striatum. {ECO:0000250|UniProtKB:P04094}.; FUNCTION: [PENK(237-258)]: Increases glutamate release in the striatum. {ECO:0000250|UniProtKB:P04094}.		aggressive behavior [GO:0002118]; behavioral fear response [GO:0001662]; cellular response to cAMP [GO:0071320]; cellular response to oxidative stress [GO:0034599]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to virus [GO:0098586]; cellular response to vitamin D [GO:0071305]; chemical synaptic transmission [GO:0007268]; general adaptation syndrome, behavioral process [GO:0051867]; glial cell proliferation [GO:0014009]; locomotory exploration behavior [GO:0035641]; neuropeptide signaling pathway [GO:0007218]; osteoblast differentiation [GO:0001649]; positive regulation of behavioral fear response [GO:2000987]; response to calcium ion [GO:0051592]; response to epinephrine [GO:0071871]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to toxic substance [GO:0009636]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; startle response [GO:0001964]; synaptic signaling via neuropeptide [GO:0099538]	axon terminus [GO:0043679]; cell body fiber [GO:0070852]; chromaffin granule lumen [GO:0034466]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; neuronal dense core vesicle lumen [GO:0099013]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; symmetric synapse [GO:0032280]; synaptic vesicle lumen [GO:0034592]	neuropeptide hormone activity [GO:0005184]; opioid peptide activity [GO:0001515]; opioid receptor binding [GO:0031628]	axon terminus [GO:0043679]; cell body fiber [GO:0070852]; chromaffin granule lumen [GO:0034466]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; neuronal dense core vesicle lumen [GO:0099013]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; symmetric synapse [GO:0032280]; synaptic vesicle lumen [GO:0034592]; neuropeptide hormone activity [GO:0005184]; opioid peptide activity [GO:0001515]; opioid receptor binding [GO:0031628]; aggressive behavior [GO:0002118]; behavioral fear response [GO:0001662]; cellular response to cAMP [GO:0071320]; cellular response to oxidative stress [GO:0034599]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to virus [GO:0098586]; cellular response to vitamin D [GO:0071305]; chemical synaptic transmission [GO:0007268]; general adaptation syndrome, behavioral process [GO:0051867]; glial cell proliferation [GO:0014009]; locomotory exploration behavior [GO:0035641]; neuropeptide signaling pathway [GO:0007218]; osteoblast differentiation [GO:0001649]; positive regulation of behavioral fear response [GO:2000987]; response to calcium ion [GO:0051592]; response to epinephrine [GO:0071871]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to toxic substance [GO:0009636]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; startle response [GO:0001964]; synaptic signaling via neuropeptide [GO:0099538]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen {ECO:0000250|UniProtKB:P01211}. Secreted {ECO:0000250|UniProtKB:P01211}.
P01213	reviewed	PDYN_HUMAN	Proenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin) [Cleaved into: Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin (Big Dyn); Dynorphin A(1-17) (Dyn-A17) (Dynorphin A); Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin (Dynorphin B) (Dyn-B) (Dynorphin B(1-13)); Leumorphin (Dynorphin B-29)]	PDYN	Homo sapiens (Human)	254	FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). {ECO:0000250}.; FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin (By similarity). {ECO:0000250}.; FUNCTION: Leumorphin has a typical opioid activity and may have anti-apoptotic effect. {ECO:0000250}.		chemical synaptic transmission [GO:0007268]; neuropeptide signaling pathway [GO:0007218]; sensory perception [GO:0007600]	axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular region [GO:0005576]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]	opioid peptide activity [GO:0001515]; opioid receptor binding [GO:0031628]	axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular region [GO:0005576]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; opioid peptide activity [GO:0001515]; opioid receptor binding [GO:0031628]; chemical synaptic transmission [GO:0007268]; neuropeptide signaling pathway [GO:0007218]; sensory perception [GO:0007600]	SUBCELLULAR LOCATION: Secreted.
P01215	reviewed	GLHA_HUMAN	Glycoprotein hormones alpha chain (Anterior pituitary glycoprotein hormones common subunit alpha) (Choriogonadotropin alpha chain) (Chorionic gonadotrophin subunit alpha) (CG-alpha) (Follicle-stimulating hormone alpha chain) (FSH-alpha) (Follitropin alpha chain) (Luteinizing hormone alpha chain) (LSH-alpha) (Lutropin alpha chain) (Thyroid-stimulating hormone alpha chain) (TSH-alpha) (Thyrotropin alpha chain)	CGA	Homo sapiens (Human)	116	FUNCTION: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. {ECO:0000269|PubMed:24692546, ECO:0000269|PubMed:2494176}.		follicle-stimulating hormone secretion [GO:0046884]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; luteinizing hormone secretion [GO:0032275]; negative regulation of organ growth [GO:0046621]; organ growth [GO:0035265]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of steroid biosynthetic process [GO:0010893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of signaling receptor activity [GO:0010469]; thyroid gland development [GO:0030878]; thyroid hormone generation [GO:0006590]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; follicle-stimulating hormone complex [GO:0016914]; Golgi lumen [GO:0005796]; pituitary gonadotropin complex [GO:0061696]	follicle-stimulating hormone activity [GO:0016913]; hormone activity [GO:0005179]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; follicle-stimulating hormone complex [GO:0016914]; Golgi lumen [GO:0005796]; pituitary gonadotropin complex [GO:0061696]; follicle-stimulating hormone activity [GO:0016913]; hormone activity [GO:0005179]; follicle-stimulating hormone secretion [GO:0046884]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; luteinizing hormone secretion [GO:0032275]; negative regulation of organ growth [GO:0046621]; organ growth [GO:0035265]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of steroid biosynthetic process [GO:0010893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of signaling receptor activity [GO:0010469]; thyroid gland development [GO:0030878]; thyroid hormone generation [GO:0006590]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24692546, ECO:0000269|PubMed:2494176}.
P01222	reviewed	TSHB_HUMAN	Thyrotropin subunit beta (Thyroid-stimulating hormone subunit beta) (TSH-B) (TSH-beta) (Thyrotropin beta chain) (Thyrotropin alfa)	TSHB	Homo sapiens (Human)	138	FUNCTION: Indispensable for the control of thyroid structure and metabolism.	MISCELLANEOUS: [Isoform 2]: Major isoform in peripheral blood leukocytes and thyroid, may form heterodimers with isoform 1. {ECO:0000305}.	anatomical structure morphogenesis [GO:0009653]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; response to calcium ion [GO:0051592]; response to estrogen [GO:0043627]; response to vitamin A [GO:0033189]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	hormone activity [GO:0005179]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; anatomical structure morphogenesis [GO:0009653]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; response to calcium ion [GO:0051592]; response to estrogen [GO:0043627]; response to vitamin A [GO:0033189]	SUBCELLULAR LOCATION: Secreted.
P01225	reviewed	FSHB_HUMAN	Follitropin subunit beta (Follicle-stimulating hormone beta subunit) (FSH-B) (FSH-beta) (Follitropin beta chain)	FSHB	Homo sapiens (Human)	129	FUNCTION: Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432). {ECO:0000269|PubMed:24692546, ECO:0000269|PubMed:2494176, ECO:0000269|PubMed:407105, ECO:0000269|PubMed:8220432}.		female gamete generation [GO:0007292]; female pregnancy [GO:0007565]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of steroid biosynthetic process [GO:0010893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone biosynthetic process [GO:0006701]; regulation of osteoclast differentiation [GO:0045670]; regulation of signaling receptor activity [GO:0010469]; Sertoli cell proliferation [GO:0060011]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; follicle-stimulating hormone complex [GO:0016914]	follicle-stimulating hormone activity [GO:0016913]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; follicle-stimulating hormone complex [GO:0016914]; follicle-stimulating hormone activity [GO:0016913]; female gamete generation [GO:0007292]; female pregnancy [GO:0007565]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of steroid biosynthetic process [GO:0010893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone biosynthetic process [GO:0006701]; regulation of osteoclast differentiation [GO:0045670]; regulation of signaling receptor activity [GO:0010469]; Sertoli cell proliferation [GO:0060011]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2494176}. Note=Efficient secretion requires dimerization with CGA. {ECO:0000269|PubMed:2494176}.
P01229	reviewed	LSHB_HUMAN	Lutropin subunit beta (Lutropin beta chain) (Luteinizing hormone subunit beta) (LH-B) (LSH-B) (LSH-beta)	LHB	Homo sapiens (Human)	141	FUNCTION: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.		cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; progesterone biosynthetic process [GO:0006701]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; pituitary gonadotropin complex [GO:0061696]	hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; pituitary gonadotropin complex [GO:0061696]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; progesterone biosynthetic process [GO:0006701]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P01236	reviewed	PRL_HUMAN	Prolactin (PRL)	PRL	Homo sapiens (Human)	227	FUNCTION: Prolactin acts primarily on the mammary gland by promoting lactation.		cell surface receptor signaling pathway [GO:0007166]; female pregnancy [GO:0007565]; lactation [GO:0007595]; mammary gland development [GO:0030879]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of lactation [GO:1903489]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; response to nutrient levels [GO:0031667]	endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	hormone activity [GO:0005179]; prolactin receptor binding [GO:0005148]	endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; prolactin receptor binding [GO:0005148]; cell surface receptor signaling pathway [GO:0007166]; female pregnancy [GO:0007565]; lactation [GO:0007595]; mammary gland development [GO:0030879]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of lactation [GO:1903489]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; response to nutrient levels [GO:0031667]	SUBCELLULAR LOCATION: Secreted.
P01241	reviewed	SOMA_HUMAN	Somatotropin (Growth hormone) (GH) (GH-N) (Growth hormone 1) (Pituitary growth hormone)	GH1	Homo sapiens (Human)	217	FUNCTION: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.	MISCELLANEOUS: Circulating GH shows a great heterogeneity due to alternative splicing, differential post-translational modifications of monomeric forms, oligomerization, optional binding to 2 different GH-binding proteins, and potentially proteolytic processing.	animal organ development [GO:0048513]; bone maturation [GO:0070977]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of growth [GO:0045927]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to estradiol [GO:0032355]; response to nutrient levels [GO:0031667]	endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth hormone receptor complex [GO:0070195]	growth factor activity [GO:0008083]; growth hormone receptor binding [GO:0005131]; hormone activity [GO:0005179]; metal ion binding [GO:0046872]; prolactin receptor binding [GO:0005148]	endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth hormone receptor complex [GO:0070195]; growth factor activity [GO:0008083]; growth hormone receptor binding [GO:0005131]; hormone activity [GO:0005179]; metal ion binding [GO:0046872]; prolactin receptor binding [GO:0005148]; animal organ development [GO:0048513]; bone maturation [GO:0070977]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of growth [GO:0045927]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to estradiol [GO:0032355]; response to nutrient levels [GO:0031667]	SUBCELLULAR LOCATION: Secreted.
P01242	reviewed	SOM2_HUMAN	Growth hormone variant (GH-V) (Growth hormone 2) (Placenta-specific growth hormone)	GH2	Homo sapiens (Human)	217	FUNCTION: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.		animal organ development [GO:0048513]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of growth [GO:0045927]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to nutrient levels [GO:0031667]	endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	growth factor activity [GO:0008083]; growth hormone receptor binding [GO:0005131]; hormone activity [GO:0005179]	endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth factor activity [GO:0008083]; growth hormone receptor binding [GO:0005131]; hormone activity [GO:0005179]; animal organ development [GO:0048513]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of growth [GO:0045927]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to nutrient levels [GO:0031667]	SUBCELLULAR LOCATION: Secreted.
P01258	reviewed	CALC_HUMAN	Calcitonin [Cleaved into: Calcitonin; Katacalcin (Calcitonin carboxyl-terminal peptide) (CCP) (PDN-21)]	CALCA CALC1	Homo sapiens (Human)	141	FUNCTION: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.; FUNCTION: Katacalcin is a potent plasma calcium-lowering peptide.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	activation of protein kinase activity [GO:0032147]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure [GO:0001984]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; embryo implantation [GO:0007566]; feeding behavior [GO:0007631]; inflammatory response [GO:0006954]; monocyte chemotaxis [GO:0002548]; negative regulation of bone resorption [GO:0045779]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ossification [GO:0030279]; negative regulation of smooth muscle contraction [GO:0045986]; neuropeptide signaling pathway [GO:0007218]; ossification [GO:0001503]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to heat [GO:0009408]; response to pain [GO:0048265]; smooth muscle contraction [GO:0006939]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; terminal bouton [GO:0043195]	calcitonin receptor binding [GO:0031716]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; terminal bouton [GO:0043195]; calcitonin receptor binding [GO:0031716]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; activation of protein kinase activity [GO:0032147]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure [GO:0001984]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; embryo implantation [GO:0007566]; feeding behavior [GO:0007631]; inflammatory response [GO:0006954]; monocyte chemotaxis [GO:0002548]; negative regulation of bone resorption [GO:0045779]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ossification [GO:0030279]; negative regulation of smooth muscle contraction [GO:0045986]; neuropeptide signaling pathway [GO:0007218]; ossification [GO:0001503]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to heat [GO:0009408]; response to pain [GO:0048265]; smooth muscle contraction [GO:0006939]	SUBCELLULAR LOCATION: Secreted.
P01266	reviewed	THYG_HUMAN	Thyroglobulin (Tg)	TG	Homo sapiens (Human)	2768	FUNCTION: Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:32025030, PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030). {ECO:0000269|PubMed:17532758, ECO:0000269|PubMed:32025030}.		hormone biosynthetic process [GO:0042446]; iodide transport [GO:0015705]; regulation of myelination [GO:0031641]; signal transduction [GO:0007165]; thyroid gland development [GO:0030878]; thyroid hormone generation [GO:0006590]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	hormone activity [GO:0005179]; identical protein binding [GO:0042802]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; hormone biosynthetic process [GO:0042446]; iodide transport [GO:0015705]; regulation of myelination [GO:0031641]; signal transduction [GO:0007165]; thyroid gland development [GO:0030878]; thyroid hormone generation [GO:0006590]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11082042, ECO:0000269|PubMed:19509106, ECO:0000269|PubMed:8626858}. Note=Secreted into the thyroid follicle lumen (PubMed:19509106). Localizes to colloid globules, a structure formed in the thyroid follicle lumen consisting of cross-linked TG arranged in concentric layers (PubMed:8626858, PubMed:11082042). {ECO:0000269|PubMed:11082042, ECO:0000269|PubMed:19509106, ECO:0000269|PubMed:8626858}.
P01270	reviewed	PTHY_HUMAN	Parathyroid hormone (PTH) (Parathormone) (Parathyrin)	PTH	Homo sapiens (Human)	115	FUNCTION: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. {ECO:0000269|PubMed:21076856}.		activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone mineralization [GO:0030282]; bone resorption [GO:0045453]; cAMP metabolic process [GO:0046058]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells within a tissue [GO:0048873]; hormone-mediated apoptotic signaling pathway [GO:0008628]; intracellular calcium ion homeostasis [GO:0006874]; macromolecule biosynthetic process [GO:0009059]; magnesium ion homeostasis [GO:0010960]; negative regulation of apoptotic process in bone marrow cell [GO:0071866]; negative regulation of bone mineralization involved in bone maturation [GO:1900158]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of gene expression [GO:0010629]; phosphate ion homeostasis [GO:0055062]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of osteoclast proliferation [GO:0090290]; positive regulation of signal transduction [GO:0009967]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; response to cadmium ion [GO:0046686]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to lead ion [GO:0010288]; response to parathyroid hormone [GO:0071107]; response to vitamin D [GO:0033280]; response to xenobiotic stimulus [GO:0009410]; Rho protein signal transduction [GO:0007266]; skeletal system development [GO:0001501]; transcription by RNA polymerase II [GO:0006366]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	hormone activity [GO:0005179]; parathyroid hormone receptor binding [GO:0031856]; peptide hormone receptor binding [GO:0051428]; receptor ligand activity [GO:0048018]; type 1 parathyroid hormone receptor binding [GO:0031857]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; parathyroid hormone receptor binding [GO:0031856]; peptide hormone receptor binding [GO:0051428]; receptor ligand activity [GO:0048018]; type 1 parathyroid hormone receptor binding [GO:0031857]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone mineralization [GO:0030282]; bone resorption [GO:0045453]; cAMP metabolic process [GO:0046058]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells within a tissue [GO:0048873]; hormone-mediated apoptotic signaling pathway [GO:0008628]; intracellular calcium ion homeostasis [GO:0006874]; macromolecule biosynthetic process [GO:0009059]; magnesium ion homeostasis [GO:0010960]; negative regulation of apoptotic process in bone marrow cell [GO:0071866]; negative regulation of bone mineralization involved in bone maturation [GO:1900158]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of gene expression [GO:0010629]; phosphate ion homeostasis [GO:0055062]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of osteoclast proliferation [GO:0090290]; positive regulation of signal transduction [GO:0009967]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; response to cadmium ion [GO:0046686]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to lead ion [GO:0010288]; response to parathyroid hormone [GO:0071107]; response to vitamin D [GO:0033280]; response to xenobiotic stimulus [GO:0009410]; Rho protein signal transduction [GO:0007266]; skeletal system development [GO:0001501]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Secreted.
P01275	reviewed	GLUC_HUMAN	Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]	GCG	Homo sapiens (Human)	180	FUNCTION: [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12626323}.; FUNCTION: [Glucagon-like peptide 1]: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). {ECO:0000269|PubMed:22037645, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Glucagon-like peptide 2]: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. {ECO:0000305|PubMed:10322410, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Oxyntomodulin]: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}.; FUNCTION: [Glicentin]: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}.	MISCELLANEOUS: In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to glucagon stimulus [GO:0071377]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; negative regulation of apoptotic process [GO:0043066]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of calcium ion import [GO:0090280]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; protein kinase A signaling [GO:0010737]; regulation of insulin secretion [GO:0050796]; response to activity [GO:0014823]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]	glucagon receptor binding [GO:0031769]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; glucagon receptor binding [GO:0031769]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to glucagon stimulus [GO:0071377]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; negative regulation of apoptotic process [GO:0043066]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of calcium ion import [GO:0090280]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; protein kinase A signaling [GO:0010737]; regulation of insulin secretion [GO:0050796]; response to activity [GO:0014823]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Glucagon-like peptide 1]: Secreted {ECO:0000269|PubMed:22037645}.
P01282	reviewed	VIP_HUMAN	VIP peptides [Cleaved into: Intestinal peptide PHV-42 (Peptide histidine valine 42); Intestinal peptide PHM-27 (Peptide histidine methioninamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)]	VIP	Homo sapiens (Human)	170	FUNCTION: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. {ECO:0000269|PubMed:15013843}.; FUNCTION: PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin. {ECO:0000269|PubMed:15013843}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; body fluid secretion [GO:0007589]; epinephrine secretion [GO:0048242]; G protein-coupled receptor signaling pathway [GO:0007186]; learning or memory [GO:0007611]; mRNA stabilization [GO:0048255]; negative regulation of apoptotic process [GO:0043066]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of smooth muscle cell proliferation [GO:0048662]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epinephrine secretion [GO:0032812]; positive regulation of penile erection [GO:0060406]; positive regulation of protein catabolic process [GO:0045732]; prolactin secretion [GO:0070459]; regulation of protein localization [GO:0032880]	extracellular region [GO:0005576]; neuron projection [GO:0043005]	hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428]	extracellular region [GO:0005576]; neuron projection [GO:0043005]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; body fluid secretion [GO:0007589]; epinephrine secretion [GO:0048242]; G protein-coupled receptor signaling pathway [GO:0007186]; learning or memory [GO:0007611]; mRNA stabilization [GO:0048255]; negative regulation of apoptotic process [GO:0043066]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of smooth muscle cell proliferation [GO:0048662]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epinephrine secretion [GO:0032812]; positive regulation of penile erection [GO:0060406]; positive regulation of protein catabolic process [GO:0045732]; prolactin secretion [GO:0070459]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Secreted.
P01286	reviewed	SLIB_HUMAN	Somatoliberin (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin)	GHRH GHRF	Homo sapiens (Human)	108	FUNCTION: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.		adenohypophysis development [GO:0021984]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell-cell signaling [GO:0007267]; growth hormone secretion [GO:0030252]; multicellular organism growth [GO:0035264]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of circadian sleep/wake cycle, REM sleep [GO:0046005]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of multicellular organism growth [GO:0040018]; response to food [GO:0032094]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; perikaryon [GO:0043204]; terminal bouton [GO:0043195]	growth hormone-releasing hormone activity [GO:0016608]; growth hormone-releasing hormone receptor binding [GO:0031770]; neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; perikaryon [GO:0043204]; terminal bouton [GO:0043195]; growth hormone-releasing hormone activity [GO:0016608]; growth hormone-releasing hormone receptor binding [GO:0031770]; neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428]; adenohypophysis development [GO:0021984]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell-cell signaling [GO:0007267]; growth hormone secretion [GO:0030252]; multicellular organism growth [GO:0035264]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of circadian sleep/wake cycle, REM sleep [GO:0046005]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of multicellular organism growth [GO:0040018]; response to food [GO:0032094]	SUBCELLULAR LOCATION: Secreted.
P01298	reviewed	PAHO_HUMAN	Pancreatic polypeptide prohormone (PH) (Pancreatic polypeptide Y) (Obinepitide) [Cleaved into: Pancreatic polypeptide (HPP) (PP); Pancreatic icosapeptide (PI)]	PPY PNP	Homo sapiens (Human)	95	FUNCTION: [Pancreatic polypeptide]: Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2. {ECO:0000269|PubMed:7493937, ECO:0000269|PubMed:7592911}.		feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; protein secretion [GO:0009306]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; neuropeptide Y receptor binding [GO:0031841]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; neuropeptide Y receptor binding [GO:0031841]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; protein secretion [GO:0009306]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7493937, ECO:0000269|PubMed:7592911, ECO:0000269|PubMed:828120}.
P01303	reviewed	NPY_HUMAN	Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]	NPY	Homo sapiens (Human)	97	FUNCTION: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.		adult feeding behavior [GO:0008343]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; intestinal epithelial cell differentiation [GO:0060575]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of appetite [GO:0032100]; regulation of blood pressure [GO:0008217]; synaptic signaling via neuropeptide [GO:0099538]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; Golgi apparatus [GO:0005794]; neuronal dense core vesicle [GO:0098992]	calcium channel regulator activity [GO:0005246]; G protein-coupled receptor activity [GO:0004930]; neuropeptide hormone activity [GO:0005184]; neuropeptide Y receptor binding [GO:0031841]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; Golgi apparatus [GO:0005794]; neuronal dense core vesicle [GO:0098992]; calcium channel regulator activity [GO:0005246]; G protein-coupled receptor activity [GO:0004930]; neuropeptide hormone activity [GO:0005184]; neuropeptide Y receptor binding [GO:0031841]; signaling receptor binding [GO:0005102]; adult feeding behavior [GO:0008343]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; intestinal epithelial cell differentiation [GO:0060575]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of appetite [GO:0032100]; regulation of blood pressure [GO:0008217]; synaptic signaling via neuropeptide [GO:0099538]	SUBCELLULAR LOCATION: Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle {ECO:0000250|UniProtKB:P07808}.
P01308	reviewed	INS_HUMAN	Insulin [Cleaved into: Insulin B chain; Insulin A chain]	INS	Homo sapiens (Human)	110	FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.		activation of protein kinase B activity [GO:0032148]; acute-phase response [GO:0006953]; alpha-beta T cell activation [GO:0046631]; cell-cell signaling [GO:0007267]; cognition [GO:0050890]; fatty acid homeostasis [GO:0055089]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of feeding behavior [GO:2000252]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of glycogen catabolic process [GO:0045818]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of NAD(P)H oxidase activity [GO:0033861]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein secretion [GO:0050709]; negative regulation of proteolysis [GO:0045861]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; neuron projection maintenance [GO:1990535]; nitric oxide-cGMP-mediated signaling pathway [GO:0038060]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of glycolytic process [GO:0045821]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein secretion [GO:0050714]; positive regulation of respiratory burst [GO:0060267]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein secretion [GO:0050708]; regulation of synaptic plasticity [GO:0048167]; regulation of transmembrane transporter activity [GO:0022898]; vasodilation [GO:0042311]; wound healing [GO:0042060]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; secretory granule lumen [GO:0034774]; transport vesicle [GO:0030133]	hormone activity [GO:0005179]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; protease binding [GO:0002020]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; secretory granule lumen [GO:0034774]; transport vesicle [GO:0030133]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; protease binding [GO:0002020]; activation of protein kinase B activity [GO:0032148]; acute-phase response [GO:0006953]; alpha-beta T cell activation [GO:0046631]; cell-cell signaling [GO:0007267]; cognition [GO:0050890]; fatty acid homeostasis [GO:0055089]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of feeding behavior [GO:2000252]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of glycogen catabolic process [GO:0045818]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of NAD(P)H oxidase activity [GO:0033861]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein secretion [GO:0050709]; negative regulation of proteolysis [GO:0045861]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; neuron projection maintenance [GO:1990535]; nitric oxide-cGMP-mediated signaling pathway [GO:0038060]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of glycolytic process [GO:0045821]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein secretion [GO:0050714]; positive regulation of respiratory burst [GO:0060267]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein secretion [GO:0050708]; regulation of synaptic plasticity [GO:0048167]; regulation of transmembrane transporter activity [GO:0022898]; vasodilation [GO:0042311]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Secreted.
P01344	reviewed	IGF2_HUMAN	Insulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]	IGF2 PP1446	Homo sapiens (Human)	180	FUNCTION: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity). {ECO:0000250|UniProtKB:P09535, ECO:0000269|PubMed:28873464, ECO:0000305|PubMed:24593700}.; FUNCTION: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. {ECO:0000269|PubMed:16912056}.	MISCELLANEOUS: The IGF2 locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is imprinted, hence silenced. Transcripts from 5 promoters P0, P1, P2, P3 and P4 code for the same protein but are differentially regulated in a developmental stage and tissue specificity. {ECO:0000305|PubMed:16531418}.; MISCELLANEOUS: [Isoform 1]: Product of 5 different transcripts regulated by 5 different promoters, denominated P0, P1, P2, P3 and P4. {ECO:0000305|PubMed:16531418}.	animal organ morphogenesis [GO:0009887]; embryonic placenta development [GO:0001892]; embryonic placenta morphogenesis [GO:0060669]; exocrine pancreas development [GO:0031017]; glucose metabolic process [GO:0006006]; in utero embryonic development [GO:0001701]; insulin receptor signaling pathway [GO:0008286]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of organ growth [GO:0046622]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of muscle cell differentiation [GO:0051147]; spongiotrophoblast cell proliferation [GO:0060720]; striated muscle cell differentiation [GO:0051146]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]	growth factor activity [GO:0008083]; hormone activity [GO:0005179]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; integrin binding [GO:0005178]; protein serine/threonine kinase activator activity [GO:0043539]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; integrin binding [GO:0005178]; protein serine/threonine kinase activator activity [GO:0043539]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; animal organ morphogenesis [GO:0009887]; embryonic placenta development [GO:0001892]; embryonic placenta morphogenesis [GO:0060669]; exocrine pancreas development [GO:0031017]; glucose metabolic process [GO:0006006]; in utero embryonic development [GO:0001701]; insulin receptor signaling pathway [GO:0008286]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of organ growth [GO:0046622]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of muscle cell differentiation [GO:0051147]; spongiotrophoblast cell proliferation [GO:0060720]; striated muscle cell differentiation [GO:0051146]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16040806}.
P01350	reviewed	GAST_HUMAN	Gastrin [Cleaved into: Gastrin-71 (Gastrin component I); Gastrin-52 (G52); Big gastrin (Gastrin component II) (Gastrin-34) (G34); Gastrin (Gastrin component III) (Gastrin-17) (G17); Gastrin-14 (G14); Gastrin-6 (G6)]	GAST GAS	Homo sapiens (Human)	101	FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.		G protein-coupled receptor signaling pathway [GO:0007186]; response to food [GO:0032094]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	hormone activity [GO:0005179]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; G protein-coupled receptor signaling pathway [GO:0007186]; response to food [GO:0032094]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P01374	reviewed	TNFB_HUMAN	Lymphotoxin-alpha (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1)	LTA TNFB TNFSF1	Homo sapiens (Human)	205	FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. {ECO:0000269|PubMed:9462508}.		apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; defense response to Gram-positive bacterium [GO:0050830]; humoral immune response [GO:0006959]; lymph node development [GO:0048535]; negative regulation of fibroblast proliferation [GO:0048147]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chronic inflammatory response to antigenic stimulus [GO:0002876]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of type II interferon production [GO:0032729]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; defense response to Gram-positive bacterium [GO:0050830]; humoral immune response [GO:0006959]; lymph node development [GO:0048535]; negative regulation of fibroblast proliferation [GO:0048147]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chronic inflammatory response to antigenic stimulus [GO:0002876]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of type II interferon production [GO:0032729]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated.
P01375	reviewed	TNFA_HUMAN	Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]	TNF TNFA TNFSF2	Homo sapiens (Human)	233	FUNCTION: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (PubMed:12794819). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity). {ECO:0000250|UniProtKB:P06804, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:22517918, ECO:0000269|PubMed:23396208}.; FUNCTION: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. {ECO:0000269|PubMed:16829952}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; antiviral innate immune response [GO:0140374]; astrocyte activation [GO:0048143]; calcium-mediated signaling [GO:0019722]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to amino acid stimulus [GO:0071230]; cellular response to amyloid-beta [GO:1904646]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nicotine [GO:0071316]; cellular response to retinoic acid [GO:0071300]; cellular response to toxic substance [GO:0097237]; cellular response to type II interferon [GO:0071346]; chronic inflammatory response to antigenic stimulus [GO:0002439]; circadian rhythm [GO:0007623]; cognition [GO:0050890]; cortical actin cytoskeleton organization [GO:0030866]; defense response to Gram-positive bacterium [GO:0050830]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; embryonic digestive tract development [GO:0048566]; endothelial cell apoptotic process [GO:0072577]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; extracellular matrix organization [GO:0030198]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; glucose metabolic process [GO:0006006]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; inflammatory response to wounding [GO:0090594]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; JNK cascade [GO:0007254]; leukocyte migration involved in inflammatory response [GO:0002523]; leukocyte tethering or rolling [GO:0050901]; liver regeneration [GO:0097421]; macrophage activation involved in immune response [GO:0002281]; microglial cell activation [GO:0001774]; necroptotic signaling pathway [GO:0097527]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of bile acid secretion [GO:0120190]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of branching involved in lung morphogenesis [GO:0061048]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of glucose import [GO:0046325]; negative regulation of heart rate [GO:0010459]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of L-glutamate import across plasma membrane [GO:0002037]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of lipid storage [GO:0010888]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of myelination [GO:0031642]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; negative regulation of neurogenesis [GO:0050768]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of protein-containing complex disassembly [GO:0043242]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of viral genome replication [GO:0045071]; osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of action potential [GO:0045760]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood microparticle formation [GO:2000334]; positive regulation of calcidiol 1-monooxygenase activity [GO:0060559]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion [GO:0045785]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine production [GO:0032722]; positive regulation of chronic inflammatory response to antigenic stimulus [GO:0002876]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fever generation [GO:0031622]; positive regulation of fractalkine production [GO:0032724]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of hair follicle development [GO:0051798]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-33 production [GO:0150129]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neutrophil activation [GO:1902565]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitrogen compound metabolic process [GO:0051173]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of podosome assembly [GO:0071803]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein transport [GO:0051222]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of superoxide dismutase activity [GO:1901671]; positive regulation of synaptic transmission [GO:0050806]; positive regulation of synoviocyte proliferation [GO:1901647]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational initiation by iron [GO:0045994]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vitamin D biosynthetic process [GO:0060557]; protein localization to plasma membrane [GO:0072659]; regulation of branching involved in salivary gland morphogenesis [GO:0060693]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of fat cell differentiation [GO:0045598]; regulation of immunoglobulin production [GO:0002637]; regulation of insulin secretion [GO:0050796]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synapse organization [GO:0050807]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to 3,3',5-triiodo-L-thyronine [GO:1905242]; response to activity [GO:0014823]; response to ethanol [GO:0045471]; response to fructose [GO:0009750]; response to glucocorticoid [GO:0051384]; response to gold nanoparticle [GO:1990268]; response to Gram-negative bacterium [GO:0140460]; response to hypoxia [GO:0001666]; response to isolation stress [GO:0035900]; response to L-glutamate [GO:1902065]; response to macrophage colony-stimulating factor [GO:0036005]; response to nutrient levels [GO:0031667]; response to salt stress [GO:0009651]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; sequestering of triglyceride [GO:0030730]; skeletal muscle contraction [GO:0003009]; toll-like receptor 3 signaling pathway [GO:0034138]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vascular endothelial growth factor production [GO:0010573]; vasodilation [GO:0042311]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	cytokine activity [GO:0005125]; death receptor agonist activity [GO:0038177]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; transcription cis-regulatory region binding [GO:0000976]; tumor necrosis factor receptor binding [GO:0005164]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; cytokine activity [GO:0005125]; death receptor agonist activity [GO:0038177]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; transcription cis-regulatory region binding [GO:0000976]; tumor necrosis factor receptor binding [GO:0005164]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; antiviral innate immune response [GO:0140374]; astrocyte activation [GO:0048143]; calcium-mediated signaling [GO:0019722]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to amino acid stimulus [GO:0071230]; cellular response to amyloid-beta [GO:1904646]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nicotine [GO:0071316]; cellular response to retinoic acid [GO:0071300]; cellular response to toxic substance [GO:0097237]; cellular response to type II interferon [GO:0071346]; chronic inflammatory response to antigenic stimulus [GO:0002439]; circadian rhythm [GO:0007623]; cognition [GO:0050890]; cortical actin cytoskeleton organization [GO:0030866]; defense response to Gram-positive bacterium [GO:0050830]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; embryonic digestive tract development [GO:0048566]; endothelial cell apoptotic process [GO:0072577]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; extracellular matrix organization [GO:0030198]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; glucose metabolic process [GO:0006006]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; inflammatory response to wounding [GO:0090594]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; JNK cascade [GO:0007254]; leukocyte migration involved in inflammatory response [GO:0002523]; leukocyte tethering or rolling [GO:0050901]; liver regeneration [GO:0097421]; macrophage activation involved in immune response [GO:0002281]; microglial cell activation [GO:0001774]; necroptotic signaling pathway [GO:0097527]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of bile acid secretion [GO:0120190]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of branching involved in lung morphogenesis [GO:0061048]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of glucose import [GO:0046325]; negative regulation of heart rate [GO:0010459]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of L-glutamate import across plasma membrane [GO:0002037]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of lipid storage [GO:0010888]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of myelination [GO:0031642]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; negative regulation of neurogenesis [GO:0050768]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of protein-containing complex disassembly [GO:0043242]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of viral genome replication [GO:0045071]; osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of action potential [GO:0045760]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood microparticle formation [GO:2000334]; positive regulation of calcidiol 1-monooxygenase activity [GO:0060559]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion [GO:0045785]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine production [GO:0032722]; positive regulation of chronic inflammatory response to antigenic stimulus [GO:0002876]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fever generation [GO:0031622]; positive regulation of fractalkine production [GO:0032724]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of hair follicle development [GO:0051798]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-33 production [GO:0150129]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neutrophil activation [GO:1902565]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitrogen compound metabolic process [GO:0051173]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of podosome assembly [GO:0071803]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein transport [GO:0051222]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of superoxide dismutase activity [GO:1901671]; positive regulation of synaptic transmission [GO:0050806]; positive regulation of synoviocyte proliferation [GO:1901647]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational initiation by iron [GO:0045994]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vitamin D biosynthetic process [GO:0060557]; protein localization to plasma membrane [GO:0072659]; regulation of branching involved in salivary gland morphogenesis [GO:0060693]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of fat cell differentiation [GO:0045598]; regulation of immunoglobulin production [GO:0002637]; regulation of insulin secretion [GO:0050796]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synapse organization [GO:0050807]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to 3,3',5-triiodo-L-thyronine [GO:1905242]; response to activity [GO:0014823]; response to ethanol [GO:0045471]; response to fructose [GO:0009750]; response to glucocorticoid [GO:0051384]; response to gold nanoparticle [GO:1990268]; response to Gram-negative bacterium [GO:0140460]; response to hypoxia [GO:0001666]; response to isolation stress [GO:0035900]; response to L-glutamate [GO:1902065]; response to macrophage colony-stimulating factor [GO:0036005]; response to nutrient levels [GO:0031667]; response to salt stress [GO:0009651]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; sequestering of triglyceride [GO:0030730]; skeletal muscle contraction [GO:0003009]; toll-like receptor 3 signaling pathway [GO:0034138]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vascular endothelial growth factor production [GO:0010573]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16829952}; Single-pass type II membrane protein {ECO:0000269|PubMed:16829952}.; SUBCELLULAR LOCATION: [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Tumor necrosis factor, soluble form]: Secreted {ECO:0000269|PubMed:23552949}.; SUBCELLULAR LOCATION: [C-domain 1]: Secreted.; SUBCELLULAR LOCATION: [C-domain 2]: Secreted.
P01562	reviewed	IFNA1_HUMAN	Interferon alpha-1/13 (IFN-alpha-1/13) (Interferon alpha-D) (LeIF D)	IFNA1; IFNA13	Homo sapiens (Human)	189	FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. {ECO:0000269|PubMed:1634550}.	MISCELLANEOUS: Interferons alpha-1 and alpha-13 have identical protein sequences.	adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
P01563	reviewed	IFNA2_HUMAN	Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A)	IFNA2 IFNA2A IFNA2B IFNA2C	Homo sapiens (Human)	188	FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. {ECO:0000269|PubMed:6159538}.		adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; receptor signaling pathway via STAT [GO:0097696]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; receptor signaling pathway via STAT [GO:0097696]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6159538}.
P01566	reviewed	IFN10_HUMAN	Interferon alpha-10 (IFN-alpha-10) (Interferon alpha-6L) (Interferon alpha-C) (LeIF C)	IFNA10	Homo sapiens (Human)	189	FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
P01567	reviewed	IFNA7_HUMAN	Interferon alpha-7 (IFN-alpha-7) (Interferon alpha-J) (LeIF J) (Interferon alpha-J1) (IFN-alpha-J1)	IFNA7	Homo sapiens (Human)	189	FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cell-cell signaling [GO:0007267]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cell-cell signaling [GO:0007267]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
P01568	reviewed	IFN21_HUMAN	Interferon alpha-21 (IFN-alpha-21) (Interferon alpha-F) (LeIF F)	IFNA21	Homo sapiens (Human)	189	FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. {ECO:0000269|PubMed:1634550}.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
P01569	reviewed	IFNA5_HUMAN	Interferon alpha-5 (IFN-alpha-5) (Interferon alpha-61) (Interferon alpha-G) (LeIF G)	IFNA5	Homo sapiens (Human)	189	FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
P01570	reviewed	IFN14_HUMAN	Interferon alpha-14 (IFN-alpha-14) (Interferon alpha-H) (LeIF H) (Interferon lambda-2-H)	IFNA14	Homo sapiens (Human)	189	FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. {ECO:0000269|PubMed:1634550}.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
P01571	reviewed	IFN17_HUMAN	Interferon alpha-17 (IFN-alpha-17) (Interferon alpha-88) (Interferon alpha-I') (LeIF I) (Interferon alpha-T)	IFNA17	Homo sapiens (Human)	189	FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. {ECO:0000269|PubMed:1634550}.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
P01574	reviewed	IFNB_HUMAN	Interferon beta (IFN-beta) (Fibroblast interferon)	IFNB1 IFB IFNB	Homo sapiens (Human)	187	FUNCTION: Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:6157094, PubMed:6171735, PubMed:8027027, PubMed:7665574, PubMed:8969169, PubMed:10049744, PubMed:10556041). Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (PubMed:8027027, PubMed:7665574, PubMed:8969169, PubMed:10049744, PubMed:10556041). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (By similarity). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity). {ECO:0000250|UniProtKB:P01575, ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:10556041, ECO:0000269|PubMed:6157094, ECO:0000269|PubMed:6171735, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:8027027, ECO:0000269|PubMed:8969169}.		adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cell surface receptor signaling pathway [GO:0007166]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of Lewy body formation [GO:0140123]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of viral genome replication [GO:0045071]; neuron cellular homeostasis [GO:0070050]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of autophagy [GO:0010508]; positive regulation of innate immune response [GO:0045089]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of MHC class I biosynthetic process [GO:0045343]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	chloramphenicol O-acetyltransferase activity [GO:0008811]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; chloramphenicol O-acetyltransferase activity [GO:0008811]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cell surface receptor signaling pathway [GO:0007166]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of Lewy body formation [GO:0140123]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of viral genome replication [GO:0045071]; neuron cellular homeostasis [GO:0070050]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of autophagy [GO:0010508]; positive regulation of innate immune response [GO:0045089]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of MHC class I biosynthetic process [GO:0045343]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6157094}.
P01579	reviewed	IFNG_HUMAN	Interferon gamma (IFN-gamma) (Immune interferon)	IFNG	Homo sapiens (Human)	166	FUNCTION: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:16914093, PubMed:8666937). Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation (PubMed:8349687). Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription (PubMed:16914093). Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits (PubMed:8666937). In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading (PubMed:8163024). Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference (PubMed:11112687). Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (PubMed:7729559). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity). {ECO:0000250|UniProtKB:P01580, ECO:0000269|PubMed:11112687, ECO:0000269|PubMed:16914093, ECO:0000269|PubMed:7729559, ECO:0000269|PubMed:8163024, ECO:0000269|PubMed:8349687, ECO:0000269|PubMed:8666937}.		adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; astrocyte activation [GO:0048143]; cell surface receptor signaling pathway [GO:0007166]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; humoral immune response [GO:0006959]; macrophage activation involved in immune response [GO:0002281]; macrophage differentiation [GO:0030225]; microglial cell activation [GO:0001774]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of tau-protein kinase activity [GO:1902948]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroinflammatory response [GO:0150076]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of autophagy [GO:0010508]; positive regulation of calcidiol 1-monooxygenase activity [GO:0060559]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [GO:0032834]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular respiration [GO:1901857]; positive regulation of chemokine production [GO:0032722]; positive regulation of core promoter binding [GO:1904798]; positive regulation of cytokine production [GO:0001819]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity [GO:0060550]; positive regulation of fructose 1,6-bisphosphate metabolic process [GO:0060552]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of iron ion import across plasma membrane [GO:1904440]; positive regulation of killing of cells of another organism [GO:0051712]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of neurogenesis [GO:0050769]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of nitrogen compound metabolic process [GO:0051173]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000309]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vitamin D biosynthetic process [GO:0060557]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of insulin secretion [GO:0050796]; response to virus [GO:0009615]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; type II interferon receptor binding [GO:0005133]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; type II interferon receptor binding [GO:0005133]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; astrocyte activation [GO:0048143]; cell surface receptor signaling pathway [GO:0007166]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; humoral immune response [GO:0006959]; macrophage activation involved in immune response [GO:0002281]; macrophage differentiation [GO:0030225]; microglial cell activation [GO:0001774]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of tau-protein kinase activity [GO:1902948]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroinflammatory response [GO:0150076]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of autophagy [GO:0010508]; positive regulation of calcidiol 1-monooxygenase activity [GO:0060559]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [GO:0032834]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular respiration [GO:1901857]; positive regulation of chemokine production [GO:0032722]; positive regulation of core promoter binding [GO:1904798]; positive regulation of cytokine production [GO:0001819]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity [GO:0060550]; positive regulation of fructose 1,6-bisphosphate metabolic process [GO:0060552]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of iron ion import across plasma membrane [GO:1904440]; positive regulation of killing of cells of another organism [GO:0051712]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of neurogenesis [GO:0050769]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of nitrogen compound metabolic process [GO:0051173]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000309]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vitamin D biosynthetic process [GO:0060557]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of insulin secretion [GO:0050796]; response to virus [GO:0009615]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196]	SUBCELLULAR LOCATION: Secreted.
P01583	reviewed	IL1A_HUMAN	Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1)	IL1A IL1F1	Homo sapiens (Human)	271	FUNCTION: Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems (PubMed:26439902). After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex (PubMed:2950091, PubMed:17507369). Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4 (PubMed:17507369). In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways (PubMed:14687581). Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage (PubMed:15679580). In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity (PubMed:26439902). {ECO:0000269|PubMed:14687581, ECO:0000269|PubMed:15679580, ECO:0000269|PubMed:17507369, ECO:0000269|PubMed:26439902, ECO:0000269|PubMed:2950091, ECO:0000269|PubMed:3258335}.		apoptotic process [GO:0006915]; cellular response to heat [GO:0034605]; cellular response to lipopolysaccharide [GO:0071222]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; cytokine-mediated signaling pathway [GO:0019221]; ectopic germ cell programmed cell death [GO:0035234]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fever generation [GO:0001660]; heart development [GO:0007507]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular sodium ion homeostasis [GO:0006883]; keratinization [GO:0031424]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of establishment of Sertoli cell barrier [GO:1904445]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell division [GO:0051781]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein secretion [GO:0050714]; positive regulation of steroid biosynthetic process [GO:0010893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of actin cytoskeleton organization [GO:0032956]; response to copper ion [GO:0046688]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to L-ascorbic acid [GO:0033591]; response to organonitrogen compound [GO:0010243]; response to ozone [GO:0010193]; spermatogenesis [GO:0007283]	cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]	copper ion binding [GO:0005507]; cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149]	cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; copper ion binding [GO:0005507]; cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149]; apoptotic process [GO:0006915]; cellular response to heat [GO:0034605]; cellular response to lipopolysaccharide [GO:0071222]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; cytokine-mediated signaling pathway [GO:0019221]; ectopic germ cell programmed cell death [GO:0035234]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fever generation [GO:0001660]; heart development [GO:0007507]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular sodium ion homeostasis [GO:0006883]; keratinization [GO:0031424]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of establishment of Sertoli cell barrier [GO:1904445]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell division [GO:0051781]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein secretion [GO:0050714]; positive regulation of steroid biosynthetic process [GO:0010893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of actin cytoskeleton organization [GO:0032956]; response to copper ion [GO:0046688]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to L-ascorbic acid [GO:0033591]; response to organonitrogen compound [GO:0010243]; response to ozone [GO:0010193]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26439902}. Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:26439902}. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). Recruited to DNA damage sites and secreted after genotoxic stress. {ECO:0000269|PubMed:32272059}.
P01584	reviewed	IL1B_HUMAN	Interleukin-1 beta (IL-1 beta) (Catabolin)	IL1B IL1F2	Homo sapiens (Human)	269	FUNCTION: Potent pro-inflammatory cytokine (PubMed:3920526, PubMed:10653850, PubMed:12794819, PubMed:28331908). Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (PubMed:3920526). Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33377178, PubMed:33883744). Acts as a sensor of S.pyogenes infection in skin: cleaved and activated by pyogenes SpeB protease, leading to an inflammatory response that prevents bacterial growth during invasive skin infection (PubMed:28331908). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:28331908, ECO:0000269|PubMed:33377178, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:3920526}.	MISCELLANEOUS: The IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated. {ECO:0000269|PubMed:15192144}.	apoptotic process [GO:0006915]; astrocyte activation [GO:0048143]; canonical NF-kappaB signal transduction [GO:0007249]; cell-cell signaling [GO:0007267]; cellular response to interleukin-17 [GO:0097398]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic substance [GO:0071310]; cellular response to xenobiotic stimulus [GO:0071466]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; ectopic germ cell programmed cell death [GO:0035234]; embryo implantation [GO:0007566]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fever generation [GO:0001660]; hyaluronan biosynthetic process [GO:0030213]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; JNK cascade [GO:0007254]; monocyte aggregation [GO:0070487]; negative regulation of adiponectin secretion [GO:0070164]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of gap junction assembly [GO:1903597]; negative regulation of glucose transmembrane transport [GO:0010829]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neurogenesis [GO:0050768]; negative regulation of synaptic transmission [GO:0050805]; neutrophil chemotaxis [GO:0030593]; positive regulation of angiogenesis [GO:0045766]; positive regulation of calcidiol 1-monooxygenase activity [GO:0060559]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of complement activation [GO:0045917]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fever generation [GO:0031622]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of myosin light chain kinase activity [GO:0035505]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of phagocytosis [GO:0050766]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of RNA biosynthetic process [GO:1902680]; positive regulation of T cell mediated immunity [GO:0002711]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of defense response to virus by host [GO:0050691]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of insulin secretion [GO:0050796]; regulation of neurogenesis [GO:0050767]; regulation of nitric-oxide synthase activity [GO:0050999]; response to ATP [GO:0033198]; response to carbohydrate [GO:0009743]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; sequestering of triglyceride [GO:0030730]; signal transduction [GO:0007165]; smooth muscle adaptation [GO:0014805]; vascular endothelial growth factor production [GO:0010573]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; secretory granule [GO:0030141]	cytokine activity [GO:0005125]; integrin binding [GO:0005178]; interleukin-1 receptor binding [GO:0005149]; protein domain specific binding [GO:0019904]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; secretory granule [GO:0030141]; cytokine activity [GO:0005125]; integrin binding [GO:0005178]; interleukin-1 receptor binding [GO:0005149]; protein domain specific binding [GO:0019904]; apoptotic process [GO:0006915]; astrocyte activation [GO:0048143]; canonical NF-kappaB signal transduction [GO:0007249]; cell-cell signaling [GO:0007267]; cellular response to interleukin-17 [GO:0097398]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic substance [GO:0071310]; cellular response to xenobiotic stimulus [GO:0071466]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; ectopic germ cell programmed cell death [GO:0035234]; embryo implantation [GO:0007566]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fever generation [GO:0001660]; hyaluronan biosynthetic process [GO:0030213]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; JNK cascade [GO:0007254]; monocyte aggregation [GO:0070487]; negative regulation of adiponectin secretion [GO:0070164]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of gap junction assembly [GO:1903597]; negative regulation of glucose transmembrane transport [GO:0010829]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neurogenesis [GO:0050768]; negative regulation of synaptic transmission [GO:0050805]; neutrophil chemotaxis [GO:0030593]; positive regulation of angiogenesis [GO:0045766]; positive regulation of calcidiol 1-monooxygenase activity [GO:0060559]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of complement activation [GO:0045917]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fever generation [GO:0031622]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of myosin light chain kinase activity [GO:0035505]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of phagocytosis [GO:0050766]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of RNA biosynthetic process [GO:1902680]; positive regulation of T cell mediated immunity [GO:0002711]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of defense response to virus by host [GO:0050691]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of insulin secretion [GO:0050796]; regulation of neurogenesis [GO:0050767]; regulation of nitric-oxide synthase activity [GO:0050999]; response to ATP [GO:0033198]; response to carbohydrate [GO:0009743]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; sequestering of triglyceride [GO:0030730]; signal transduction [GO:0007165]; smooth muscle adaptation [GO:0014805]; vascular endothelial growth factor production [GO:0010573]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15192144}. Secreted {ECO:0000269|PubMed:11728343, ECO:0000269|PubMed:15192144, ECO:0000269|PubMed:33883744}. Lysosome {ECO:0000269|PubMed:15192144}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic (PubMed:15192144). In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted (PubMed:24201029, PubMed:33377178, PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:15192144, ECO:0000269|PubMed:24201029, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33377178, ECO:0000269|PubMed:33883744}.
P01588	reviewed	EPO_HUMAN	Erythropoietin (Epoetin)	EPO	Homo sapiens (Human)	193	FUNCTION: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. {ECO:0000269|PubMed:28283061}.		acute-phase response [GO:0006953]; blood circulation [GO:0008015]; cellular hyperosmotic response [GO:0071474]; embryo implantation [GO:0007566]; erythrocyte differentiation [GO:0030218]; erythrocyte maturation [GO:0043249]; erythropoietin-mediated signaling pathway [GO:0038162]; hemoglobin biosynthetic process [GO:0042541]; myeloid cell apoptotic process [GO:0033028]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of cation channel activity [GO:2001258]; negative regulation of erythrocyte apoptotic process [GO:1902251]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to axon injury [GO:0048678]; response to dexamethasone [GO:0071548]; response to electrical stimulus [GO:0051602]; response to estrogen [GO:0043627]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to salt stress [GO:0009651]; response to testosterone [GO:0033574]; response to vitamin A [GO:0033189]; signal transduction [GO:0007165]	cell body [GO:0044297]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; erythropoietin receptor binding [GO:0005128]; hormone activity [GO:0005179]; protein kinase activator activity [GO:0030295]	cell body [GO:0044297]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; erythropoietin receptor binding [GO:0005128]; hormone activity [GO:0005179]; protein kinase activator activity [GO:0030295]; acute-phase response [GO:0006953]; blood circulation [GO:0008015]; cellular hyperosmotic response [GO:0071474]; embryo implantation [GO:0007566]; erythrocyte differentiation [GO:0030218]; erythrocyte maturation [GO:0043249]; erythropoietin-mediated signaling pathway [GO:0038162]; hemoglobin biosynthetic process [GO:0042541]; myeloid cell apoptotic process [GO:0033028]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of cation channel activity [GO:2001258]; negative regulation of erythrocyte apoptotic process [GO:1902251]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to axon injury [GO:0048678]; response to dexamethasone [GO:0071548]; response to electrical stimulus [GO:0051602]; response to estrogen [GO:0043627]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to salt stress [GO:0009651]; response to testosterone [GO:0033574]; response to vitamin A [GO:0033189]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32989016}.
P01589	reviewed	IL2RA_HUMAN	Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25)	IL2RA	Homo sapiens (Human)	272	FUNCTION: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. {ECO:0000269|PubMed:23416241, ECO:0000269|PubMed:24116927}.		activated T cell proliferation [GO:0050798]; activation-induced cell death of T cells [GO:0006924]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; inflammatory response [GO:0006954]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-2-mediated signaling pathway [GO:0038110]; negative regulation of inflammatory response [GO:0050728]; negative regulation of T cell proliferation [GO:0042130]; Notch signaling pathway [GO:0007219]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of T cell differentiation [GO:0045582]; regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000561]; regulation of T cell homeostatic proliferation [GO:0046013]; regulation of T cell tolerance induction [GO:0002664]	external side of plasma membrane [GO:0009897]; interleukin-2 receptor complex [GO:0005893]; plasma membrane [GO:0005886]	interleukin-2 binding [GO:0019976]; interleukin-2 receptor activity [GO:0004911]	external side of plasma membrane [GO:0009897]; interleukin-2 receptor complex [GO:0005893]; plasma membrane [GO:0005886]; interleukin-2 binding [GO:0019976]; interleukin-2 receptor activity [GO:0004911]; activated T cell proliferation [GO:0050798]; activation-induced cell death of T cells [GO:0006924]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; inflammatory response [GO:0006954]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-2-mediated signaling pathway [GO:0038110]; negative regulation of inflammatory response [GO:0050728]; negative regulation of T cell proliferation [GO:0042130]; Notch signaling pathway [GO:0007219]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of T cell differentiation [GO:0045582]; regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000561]; regulation of T cell homeostatic proliferation [GO:0046013]; regulation of T cell tolerance induction [GO:0002664]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P01591	reviewed	IGJ_HUMAN	Immunoglobulin J chain (Joining chain of multimeric IgA and IgM)	JCHAIN IGCJ IGJ	Homo sapiens (Human)	159	FUNCTION: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component. {ECO:0000250|UniProtKB:P01592}.		adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; glomerular filtration [GO:0003094]; humoral immune response [GO:0006959]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of respiratory burst [GO:0060267]; protein-containing complex assembly [GO:0065003]; retina homeostasis [GO:0001895]	blood microparticle [GO:0072562]; dimeric IgA immunoglobulin complex [GO:0071750]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; monomeric IgA immunoglobulin complex [GO:0071748]; pentameric IgM immunoglobulin complex [GO:0071756]; secretory dimeric IgA immunoglobulin complex [GO:0071752]; secretory IgA immunoglobulin complex [GO:0071751]	antigen binding [GO:0003823]; IgA binding [GO:0019862]; immunoglobulin receptor binding [GO:0034987]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]	blood microparticle [GO:0072562]; dimeric IgA immunoglobulin complex [GO:0071750]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; monomeric IgA immunoglobulin complex [GO:0071748]; pentameric IgM immunoglobulin complex [GO:0071756]; secretory dimeric IgA immunoglobulin complex [GO:0071752]; secretory IgA immunoglobulin complex [GO:0071751]; antigen binding [GO:0003823]; IgA binding [GO:0019862]; immunoglobulin receptor binding [GO:0034987]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; glomerular filtration [GO:0003094]; humoral immune response [GO:0006959]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of respiratory burst [GO:0060267]; protein-containing complex assembly [GO:0065003]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01592}.
P01593	reviewed	KVD33_HUMAN	Immunoglobulin kappa variable 1D-33 (Ig kappa chain V-I region AG) (Ig kappa chain V-I region Bi) (Ig kappa chain V-I region Lay) (Ig kappa chain V-I region Ni) (Ig kappa chain V-I region Rei) (Ig kappa chain V-I region Roy) (Ig kappa chain V-I region Scw) (Ig kappa chain V-I region WAT)	IGKV1D-33	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01594	reviewed	KV133_HUMAN	Immunoglobulin kappa variable 1-33 (Ig kappa chain V-I region AU) (Ig kappa chain V-I region Ka)	IGKV1-33	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]; identical protein binding [GO:0042802]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; identical protein binding [GO:0042802]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01597	reviewed	KV139_HUMAN	Immunoglobulin kappa variable 1-39 (Ig kappa chain V-I region DEE) (Ig kappa chain V-I region Hau) (Ig kappa chain V-I region Mev) (Ig kappa chain V-I region OU) (Ig kappa chain V-I region Walker)	IGKV1-39	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01599	reviewed	KV117_HUMAN	Immunoglobulin kappa variable 1-17 (Ig kappa chain V-I region Gal) (Ig kappa chain V-I region WEA)	IGKV1-17	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01602	reviewed	KV105_HUMAN	Immunoglobulin kappa variable 1-5 (Ig kappa chain V-I region CAR) (Ig kappa chain V-I region EU) (Ig kappa chain V-I region HK102) (Ig kappa chain V-I region Kue)	IGKV1-5	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01611	reviewed	KVD12_HUMAN	Immunoglobulin kappa variable 1D-12 (Ig kappa chain V-I region Wes)	IGKV1D-12	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01615	reviewed	KVD28_HUMAN	Immunoglobulin kappa variable 2D-28 (Ig kappa chain V-II region FR) (Ig kappa chain V-II region GM607) (Ig kappa chain V-II region MIL) (Ig kappa chain V-II region TEW)	IGKV2D-28	Homo sapiens (Human)	120	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01619	reviewed	KV320_HUMAN	Immunoglobulin kappa variable 3-20 (Ig kappa chain V-III region B6) (Ig kappa chain V-III region GOL) (Ig kappa chain V-III region HAH) (Ig kappa chain V-III region HIC) (Ig kappa chain V-III region IARC/BL41) (Ig kappa chain V-III region NG9) (Ig kappa chain V-III region SIE) (Ig kappa chain V-III region Ti) (Ig kappa chain V-III region WOL)	IGKV3-20	Homo sapiens (Human)	116	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; glomerular filtration [GO:0003094]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; monomeric IgA immunoglobulin complex [GO:0071748]; pentameric IgM immunoglobulin complex [GO:0071756]; plasma membrane [GO:0005886]; secretory IgA immunoglobulin complex [GO:0071751]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; monomeric IgA immunoglobulin complex [GO:0071748]; pentameric IgM immunoglobulin complex [GO:0071756]; plasma membrane [GO:0005886]; secretory IgA immunoglobulin complex [GO:0071751]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; glomerular filtration [GO:0003094]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01699	reviewed	LV144_HUMAN	Immunoglobulin lambda variable 1-44 (Ig lambda chain V-I region MEM) (Ig lambda chain V-I region VOR)	IGLV1-44	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01700	reviewed	LV147_HUMAN	Immunoglobulin lambda variable 1-47 (Ig lambda chain V-I region HA) (Ig lambda chain V-I region WAH)	IGLV1-47	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01701	reviewed	LV151_HUMAN	Immunoglobulin lambda variable 1-51 (Ig lambda chain V-I region BL2) (Ig lambda chain V-I region EPS) (Ig lambda chain V-I region NEW) (Ig lambda chain V-I region NIG-64)	IGLV1-51	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01704	reviewed	LV214_HUMAN	Immunoglobulin lambda variable 2-14 (Ig lambda chain V-II region NIG-84) (Ig lambda chain V-II region TOG) (Ig lambda chain V-II region VIL)	IGLV2-14	Homo sapiens (Human)	120	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01705	reviewed	LV223_HUMAN	Immunoglobulin lambda variable 2-23 (Ig lambda chain V-II region NEI)	IGLV2-23	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01706	reviewed	LV211_HUMAN	Immunoglobulin lambda variable 2-11 (Ig gamma lambda chain V-II region DOT) (Ig lambda chain V-II region BOH) (Ig lambda chain V-II region BUR) (Ig lambda chain V-II region NIG-58) (Ig lambda chain V-II region TRO) (Ig lambda chain V-II region WIN)	IGLV2-11	Homo sapiens (Human)	119	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01709	reviewed	LV208_HUMAN	Immunoglobulin lambda variable 2-8 (Ig lambda chain V-II region BO) (Ig lambda chain V-II region MGC)	IGLV2-8	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01721	reviewed	LV657_HUMAN	Immunoglobulin lambda variable 6-57 (Ig lambda chain V-VI region AR) (Ig lambda chain V-VI region EB4) (Ig lambda chain V-VI region NIG-48) (Ig lambda chain V-VI region SUT) (Ig lambda chain V-VI region WLT)	IGLV6-57	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01730	reviewed	CD4_HUMAN	T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)	CD4	Homo sapiens (Human)	458	FUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. {ECO:0000269|PubMed:16951326, ECO:0000269|PubMed:24942581, ECO:0000269|PubMed:2823150, ECO:0000269|PubMed:7604010}.; FUNCTION: (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607). {ECO:0000269|PubMed:12089508, ECO:0000269|PubMed:16331979, ECO:0000269|PubMed:17346169, ECO:0000269|PubMed:2214026, ECO:0000269|PubMed:7909607, ECO:0000269|PubMed:9641677}.		adaptive immune response [GO:0002250]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; defense response to Gram-negative bacterium [GO:0050829]; enzyme-linked receptor protein signaling pathway [GO:0007167]; helper T cell enhancement of adaptive immune response [GO:0035397]; immune response [GO:0006955]; interleukin-15-mediated signaling pathway [GO:0035723]; macrophage differentiation [GO:0030225]; maintenance of protein location in cell [GO:0032507]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell activation [GO:0050870]; positive regulation of viral entry into host cell [GO:0046598]; regulation of calcium ion transport [GO:0051924]; regulation of T cell activation [GO:0050863]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell selection [GO:0045058]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	coreceptor activity [GO:0015026]; enzyme binding [GO:0019899]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; interleukin-16 binding [GO:0042011]; interleukin-16 receptor activity [GO:0042012]; lipid binding [GO:0008289]; MHC class II protein binding [GO:0042289]; MHC class II protein complex binding [GO:0023026]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]	clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; coreceptor activity [GO:0015026]; enzyme binding [GO:0019899]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; interleukin-16 binding [GO:0042011]; interleukin-16 receptor activity [GO:0042012]; lipid binding [GO:0008289]; MHC class II protein binding [GO:0042289]; MHC class II protein complex binding [GO:0023026]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]; adaptive immune response [GO:0002250]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; defense response to Gram-negative bacterium [GO:0050829]; enzyme-linked receptor protein signaling pathway [GO:0007167]; helper T cell enhancement of adaptive immune response [GO:0035397]; immune response [GO:0006955]; interleukin-15-mediated signaling pathway [GO:0035723]; macrophage differentiation [GO:0030225]; maintenance of protein location in cell [GO:0032507]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell activation [GO:0050870]; positive regulation of viral entry into host cell [GO:0046598]; regulation of calcium ion transport [GO:0051924]; regulation of T cell activation [GO:0050863]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell selection [GO:0045058]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12089508, ECO:0000269|PubMed:12517957, ECO:0000269|PubMed:2823150, ECO:0000269|PubMed:2990730}; Single-pass type I membrane protein {ECO:0000269|PubMed:12517957, ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:1708753}. Note=Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
P01732	reviewed	CD8A_HUMAN	T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)	CD8A MAL	Homo sapiens (Human)	235	FUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. {ECO:0000269|PubMed:16236125, ECO:0000269|PubMed:17678538, ECO:0000269|PubMed:23657257, ECO:0000269|PubMed:26082771}.		adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; cell surface receptor signaling pathway [GO:0007166]; cytotoxic T cell differentiation [GO:0045065]; immune response [GO:0006955]; T cell activation [GO:0042110]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; receptor complex [GO:0043235]; T cell receptor complex [GO:0042101]	coreceptor activity [GO:0015026]; MHC class I protein binding [GO:0042288]; MHC class I protein complex binding [GO:0023024]; protein kinase binding [GO:0019901]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; receptor complex [GO:0043235]; T cell receptor complex [GO:0042101]; coreceptor activity [GO:0015026]; MHC class I protein binding [GO:0042288]; MHC class I protein complex binding [GO:0023024]; protein kinase binding [GO:0019901]; adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; cell surface receptor signaling pathway [GO:0007166]; cytotoxic T cell differentiation [GO:0045065]; immune response [GO:0006955]; T cell activation [GO:0042110]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:1460019, ECO:0000269|PubMed:17341584, ECO:0000269|PubMed:17678538}; Single-pass type I membrane protein. Note=CD8A localizes to lipid rafts only when associated with its partner CD8B. {ECO:0000269|PubMed:17341584}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:7923932}.
P01742	reviewed	HV169_HUMAN	Immunoglobulin heavy variable 1-69 (Ig heavy chain V-I region EU) (Ig heavy chain V-I region SIE) (Ig heavy chain V-I region WOL)	IGHV1-69	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01764	reviewed	HV323_HUMAN	Immunoglobulin heavy variable 3-23 (Ig heavy chain V-III region LAY) (Ig heavy chain V-III region POM) (Ig heavy chain V-III region TEI) (Ig heavy chain V-III region TIL) (Ig heavy chain V-III region TUR) (Ig heavy chain V-III region VH26) (Ig heavy chain V-III region WAS) (Ig heavy chain V-III region ZAP)	IGHV3-23	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01768	reviewed	HV330_HUMAN	Immunoglobulin heavy variable 3-30 (Ig heavy chain V-III region BUR) (Ig heavy chain V-III region CAM) (Ig heavy chain V-III region GA) (Ig heavy chain V-III region NIE)	IGHV3-30	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01772	reviewed	HV333_HUMAN	Immunoglobulin heavy variable 3-33 (Ig heavy chain V-III region HIL) (Ig heavy chain V-III region KOL)	IGHV3-33	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01814	reviewed	HV270_HUMAN	Immunoglobulin heavy variable 2-70 (Ig heavy chain V-II region COR) (Ig heavy chain V-II region DAW) (Ig heavy chain V-II region OU) (Ig heavy chain V-II region SESS)	IGHV2-70	Homo sapiens (Human)	119	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01833	reviewed	PIGR_HUMAN	Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component]	PIGR	Homo sapiens (Human)	764	FUNCTION: [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. {ECO:0000269|PubMed:10229845, ECO:0000269|PubMed:15530357, ECO:0000269|PubMed:9379029}.; FUNCTION: [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244). {ECO:0000269|PubMed:12150896, ECO:0000269|PubMed:16543244}.		detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc receptor signaling pathway [GO:0038093]; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor [GO:0002415]; receptor clustering [GO:0043113]; retina homeostasis [GO:0001895]	azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; secretory IgA immunoglobulin complex [GO:0071751]	polymeric immunoglobulin receptor activity [GO:0001792]; transmembrane signaling receptor activity [GO:0004888]	azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; secretory IgA immunoglobulin complex [GO:0071751]; polymeric immunoglobulin receptor activity [GO:0001792]; transmembrane signaling receptor activity [GO:0004888]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc receptor signaling pathway [GO:0038093]; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor [GO:0002415]; receptor clustering [GO:0043113]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: [Polymeric immunoglobulin receptor]: Cell membrane {ECO:0000269|PubMed:9379029}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Secretory component]: Secreted {ECO:0000269|PubMed:16543244, ECO:0000269|PubMed:19079336, ECO:0000269|PubMed:8292260}.
P01834	reviewed	IGKC_HUMAN	Immunoglobulin kappa constant (Ig kappa chain C region) (Ig kappa chain C region AG) (Ig kappa chain C region CUM) (Ig kappa chain C region EU) (Ig kappa chain C region OU) (Ig kappa chain C region ROY) (Ig kappa chain C region TI)	IGKC	Homo sapiens (Human)	107	FUNCTION: Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.		adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; retina homeostasis [GO:0001895]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgD immunoglobulin complex [GO:0071738]; IgE immunoglobulin complex [GO:0071742]; IgG immunoglobulin complex [GO:0071735]; IgM immunoglobulin complex [GO:0071753]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgD immunoglobulin complex [GO:0071738]; IgE immunoglobulin complex [GO:0071742]; IgG immunoglobulin complex [GO:0071735]; IgM immunoglobulin complex [GO:0071753]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01848	reviewed	TRAC_HUMAN	T cell receptor alpha chain constant	TRAC TCRA	Homo sapiens (Human)	140	FUNCTION: Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; response to bacterium [GO:0009617]; T cell receptor signaling pathway [GO:0050852]	alpha-beta T cell receptor complex [GO:0042105]; plasma membrane [GO:0005886]		alpha-beta T cell receptor complex [GO:0042105]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; response to bacterium [GO:0009617]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
P01850	reviewed	TRBC1_HUMAN	T cell receptor beta constant 1	TRBC1	Homo sapiens (Human)	176	FUNCTION: Constant region of T cell receptor (TR) beta chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:9382891, PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000269|PubMed:9382891, ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; immune response [GO:0006955]; T cell receptor signaling pathway [GO:0050852]	alpha-beta T cell receptor complex [GO:0042105]; membrane [GO:0016020]; plasma membrane [GO:0005886]		alpha-beta T cell receptor complex [GO:0042105]; membrane [GO:0016020]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; immune response [GO:0006955]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
P01854	reviewed	IGHE_HUMAN	Immunoglobulin heavy constant epsilon (Ig epsilon chain C region) (Ig epsilon chain C region ND)	IGHE	Homo sapiens (Human)	546	FUNCTION: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.; FUNCTION: [Isoform 1]: Constant region of secreted IgE, also known as the Fc region of IgE antibody. Mediates IgE effector functions on myeloid and lymphoid cells primarily via two Fc receptors, the high-affinity IgE Fc receptor complex/FCER1A:MS4A2:FCGR1A and the low-affinity FCER2 receptor, which upon antigen/allergen cross-linking initiate signaling pathways that lead to immune cell activation and differentiation (PubMed:2167225, PubMed:8114916, PubMed:7544003, PubMed:8551243, PubMed:25629393, PubMed:33840121). Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions (PubMed:8114916, PubMed:7544003, PubMed:8551243, PubMed:25629393, PubMed:33840121). Stimulates the high-affinity IgE Fc receptor complex/FCER1A:MS4A2:FCGR1A on mast cells, basophils and eosinophils leading to secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes (PubMed:8114916, PubMed:8551243, PubMed:25629393). On macrophages, cross-linking of FCER2 by IgE immune complexes induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway (PubMed:7544003). Activates macrophages to kill tumor cells via antigen-specific antibody-dependent cytotoxicity (ADCC). Triggers differentiation of quiescent M0 macrophages toward M1 state and reprograms M2 macrophages toward a proinflammatory state with antitumor functions (PubMed:30956175). Stimulates FCER2 on B cells and initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225). {ECO:0000269|PubMed:2167225, ECO:0000269|PubMed:25629393, ECO:0000269|PubMed:30956175, ECO:0000269|PubMed:33840121, ECO:0000269|PubMed:7544003, ECO:0000269|PubMed:8114916, ECO:0000269|PubMed:8551243, ECO:0000303|PubMed:20176268, ECO:0000305|PubMed:10917520, ECO:0000305|PubMed:7995941}.; FUNCTION: [Isoform 2]: Constant region of membrane-bound IgE (long mIgE), part of the B cell receptor complex (BCR). Upon antigen cross-linking triggers quick BCR signaling, ensuring survival of IgE-switched B cells and differentiation into plasma cells, thus regulating both primary and memory IgE responses. {ECO:0000269|PubMed:20458139, ECO:0000269|PubMed:8976175}.; FUNCTION: [Isoform 3]: Constant region of membrane-bound IgE (short mIgE), part of the B cell receptor complex (BCR). Upon antigen cross-linking initiates slower but sustained BCR signaling that negatively regulates mature B cell proliferation. {ECO:0000269|PubMed:8976175}.		adaptive immune memory response [GO:0090716]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; antibody-dependent cellular cytotoxicity [GO:0001788]; B cell antigen processing and presentation [GO:0002450]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; eosinophil degranulation [GO:0043308]; Fc receptor-mediated immune complex endocytosis [GO:0160006]; immune response [GO:0006955]; inflammatory response [GO:0006954]; macrophage activation [GO:0042116]; macrophage differentiation [GO:0030225]; mast cell degranulation [GO:0043303]; primary adaptive immune response [GO:0090720]; type 2 immune response [GO:0042092]; type I hypersensitivity [GO:0016068]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgE B cell receptor complex [GO:0071744]; IgE immunoglobulin complex [GO:0071742]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgE B cell receptor complex [GO:0071744]; IgE immunoglobulin complex [GO:0071742]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]; adaptive immune memory response [GO:0090716]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; antibody-dependent cellular cytotoxicity [GO:0001788]; B cell antigen processing and presentation [GO:0002450]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; eosinophil degranulation [GO:0043308]; Fc receptor-mediated immune complex endocytosis [GO:0160006]; immune response [GO:0006955]; inflammatory response [GO:0006954]; macrophage activation [GO:0042116]; macrophage differentiation [GO:0030225]; mast cell degranulation [GO:0043303]; primary adaptive immune response [GO:0090720]; type 2 immune response [GO:0042092]; type I hypersensitivity [GO:0016068]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000269|PubMed:7995941}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:20458139, ECO:0000269|PubMed:7995941, ECO:0000269|PubMed:8976175}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:8976175}; Single-pass type I membrane protein {ECO:0000255}.
P01857	reviewed	IGHG1_HUMAN	Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)	IGHG1	Homo sapiens (Human)	399	FUNCTION: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Mediates IgG effector functions on monocytes triggering ADCC of virus-infected cells. {ECO:0000269|PubMed:11711607, ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.		adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; antibody-dependent cellular cytotoxicity [GO:0001788]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; complement-dependent cytotoxicity [GO:0097278]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgG immunoglobulin complex [GO:0071735]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]; Fc-gamma receptor I complex binding [GO:0034988]; immunoglobulin receptor binding [GO:0034987]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgG immunoglobulin complex [GO:0071735]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; Fc-gamma receptor I complex binding [GO:0034988]; immunoglobulin receptor binding [GO:0034987]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; antibody-dependent cellular cytotoxicity [GO:0001788]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; complement-dependent cytotoxicity [GO:0097278]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}; Single-pass membrane protein {ECO:0000255}.
P01859	reviewed	IGHG2_HUMAN	Immunoglobulin heavy constant gamma 2 (Ig gamma-2 chain C region) (Ig gamma-2 chain C region DOT) (Ig gamma-2 chain C region TIL) (Ig gamma-2 chain C region ZIE)	IGHG2	Homo sapiens (Human)	395	FUNCTION: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.		adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgG immunoglobulin complex [GO:0071735]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgG immunoglobulin complex [GO:0071735]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}; Single-pass membrane protein {ECO:0000255}.
P01860	reviewed	IGHG3_HUMAN	Immunoglobulin heavy constant gamma 3 (HDC) (Heavy chain disease protein) (Ig gamma-3 chain C region)	IGHG3	Homo sapiens (Human)	446	FUNCTION: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.		adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; retina homeostasis [GO:0001895]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgG immunoglobulin complex [GO:0071735]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgG immunoglobulin complex [GO:0071735]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}; Single-pass membrane protein {ECO:0000255}.
P01861	reviewed	IGHG4_HUMAN	Immunoglobulin heavy constant gamma 4 (Ig gamma-4 chain C region)	IGHG4	Homo sapiens (Human)	396	FUNCTION: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.		adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgG immunoglobulin complex [GO:0071735]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgG immunoglobulin complex [GO:0071735]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}; Single-pass membrane protein {ECO:0000255}.
P01871	reviewed	IGHM_HUMAN	Immunoglobulin heavy constant mu (Ig mu chain C region) (Ig mu chain C region BOT) (Ig mu chain C region GAL) (Ig mu chain C region OU)	IGHM	Homo sapiens (Human)	474	FUNCTION: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553). {ECO:0000269|PubMed:3137579, ECO:0000303|PubMed:16895553, ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.		adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; hexameric IgM immunoglobulin complex [GO:0071757]; IgM immunoglobulin complex [GO:0071753]; immunoglobulin complex, circulating [GO:0042571]; pentameric IgM immunoglobulin complex [GO:0071756]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; hexameric IgM immunoglobulin complex [GO:0071757]; IgM immunoglobulin complex [GO:0071753]; immunoglobulin complex, circulating [GO:0042571]; pentameric IgM immunoglobulin complex [GO:0071756]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.
P01876	reviewed	IGHA1_HUMAN	Immunoglobulin heavy constant alpha 1 (Ig alpha-1 chain C region) (Ig alpha-1 chain C region BUR) (Ig alpha-1 chain C region TRO)	IGHA1	Homo sapiens (Human)	398	FUNCTION: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:2241915}.		adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; glomerular filtration [GO:0003094]; immune response [GO:0006955]; positive regulation of respiratory burst [GO:0060267]; retina homeostasis [GO:0001895]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgG immunoglobulin complex [GO:0071735]; immunoglobulin complex, circulating [GO:0042571]; monomeric IgA immunoglobulin complex [GO:0071748]; plasma membrane [GO:0005886]; secretory dimeric IgA immunoglobulin complex [GO:0071752]; secretory IgA immunoglobulin complex [GO:0071751]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgG immunoglobulin complex [GO:0071735]; immunoglobulin complex, circulating [GO:0042571]; monomeric IgA immunoglobulin complex [GO:0071748]; plasma membrane [GO:0005886]; secretory dimeric IgA immunoglobulin complex [GO:0071752]; secretory IgA immunoglobulin complex [GO:0071751]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; glomerular filtration [GO:0003094]; immune response [GO:0006955]; positive regulation of respiratory burst [GO:0060267]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}; Single-pass type I membrane protein {ECO:0000255}.
P01877	reviewed	IGHA2_HUMAN	Immunoglobulin heavy constant alpha 2 (Ig alpha-2 chain C region) (Ig alpha-2 chain C region BUT) (Ig alpha-2 chain C region LAN)	IGHA2	Homo sapiens (Human)	391	FUNCTION: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:2241915}.		adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; glomerular filtration [GO:0003094]; immune response [GO:0006955]; positive regulation of respiratory burst [GO:0060267]; retina homeostasis [GO:0001895]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; immunoglobulin complex, circulating [GO:0042571]; monomeric IgA immunoglobulin complex [GO:0071748]; plasma membrane [GO:0005886]; secretory dimeric IgA immunoglobulin complex [GO:0071752]; secretory IgA immunoglobulin complex [GO:0071751]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; immunoglobulin complex, circulating [GO:0042571]; monomeric IgA immunoglobulin complex [GO:0071748]; plasma membrane [GO:0005886]; secretory dimeric IgA immunoglobulin complex [GO:0071752]; secretory IgA immunoglobulin complex [GO:0071751]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; glomerular filtration [GO:0003094]; immune response [GO:0006955]; positive regulation of respiratory burst [GO:0060267]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}; Single-pass type I membrane protein {ECO:0000255}.
P01880	reviewed	IGHD_HUMAN	Immunoglobulin heavy constant delta (Ig delta chain C region) (Ig delta chain C region NIG-65) (Ig delta chain C region WAH)	IGHD	Homo sapiens (Human)	430	FUNCTION: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD (PubMed:8774350, PubMed:10702483, PubMed:11282392). {ECO:0000269|PubMed:8774350, ECO:0000303|PubMed:10702483, ECO:0000303|PubMed:11282392, ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.	MISCELLANEOUS: IgD is not present in every species and this does not relate to phylogeny and evolution. IgD is present in primates, dog, mouse and rat whereas it is undetectable in rabbit, guinea pig, swine, cattle, sheep and Xenopus.	adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; positive regulation of interleukin-1 production [GO:0032732]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; IgD immunoglobulin complex [GO:0071738]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; IgD immunoglobulin complex [GO:0071738]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; positive regulation of interleukin-1 production [GO:0032732]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000303|PubMed:11282392}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein {ECO:0000303|PubMed:11282392}.
P01889	reviewed	HLAB_HUMAN	HLA class I histocompatibility antigen, B alpha chain (Human leukocyte antigen B) (HLA-B)	HLA-B HLAB	Homo sapiens (Human)	362	FUNCTION: Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:25808313, PubMed:29531227, PubMed:9620674, PubMed:23209413). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7743181, PubMed:18991276). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:29531227, PubMed:9620674, PubMed:24600035). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227). {ECO:0000269|PubMed:18991276, ECO:0000269|PubMed:23209413, ECO:0000269|PubMed:24600035, ECO:0000269|PubMed:25808313, ECO:0000269|PubMed:29531227, ECO:0000269|PubMed:7743181, ECO:0000269|PubMed:9620674}.; FUNCTION: Allele B*07:02: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and mainly a Leu anchor residue at the C-terminus (PubMed:7743181). Presents a long peptide (APRGPHGGAASGL) derived from the cancer-testis antigen CTAG1A/NY-ESO-1, eliciting a polyclonal CD8-positive T cell response against tumor cells (PubMed:29531227). Presents viral epitopes derived from HIV-1 gag-pol (TPQDLNTML) and Nef (RPQVPLRPM) (PubMed:25808313). Presents an immunodominant epitope derived from SARS-CoV-2 N/nucleoprotein (SPRWYFYYL) (PubMed:32887977). Displays self-peptides including a peptide derived from the signal sequence of HLA-DPB1 (APRTVALTA) (PubMed:7743181). {ECO:0000269|PubMed:25808313, ECO:0000269|PubMed:29531227, ECO:0000269|PubMed:32887977, ECO:0000269|PubMed:7743181}.; FUNCTION: Allele B*08:01: Presents to CD8-positive T cells viral epitopes derived from EBV/HHV-4 EBNA3 (QAKWRLQTL), eliciting cytotoxic T cell response. {ECO:0000269|PubMed:9620674}.; FUNCTION: Allele B*13:02: Presents multiple HIV-1 epitopes derived from gag (RQANFLGKI, GQMREPRGSDI), nef (RQDILDLWI), gag-pol (RQYDQILIE, GQGQWTYQI) and rev (LQLPPLERL), all having in common a Gln residue at position 2 and mainly hydrophobic amino acids Leu, Ile or Val at the C-terminus. Associated with succesful control of HIV-1 infection. {ECO:0000269|PubMed:17251285}.; FUNCTION: Allele B*18:01: Preferentially presents octomeric and nonameric peptides sharing a common motif, namely a Glu at position 2 and Phe or Tyr anchor residues at the C-terminus (PubMed:14978097, PubMed:23749632, PubMed:18991276). Presents an EBV/HHV-4 epitope derived from BZLF1 (SELEIKRY) (PubMed:23749632). May present to CD8-positive T cells an antigenic peptide derived from MAGEA3 (MEVDPIGHLY), triggering an anti-tumor immune response (PubMed:12366779). May display a broad repertoire of self-peptides with a preference for peptides derived from RNA-binding proteins (PubMed:14978097). {ECO:0000269|PubMed:12366779, ECO:0000269|PubMed:14978097, ECO:0000269|PubMed:18991276, ECO:0000269|PubMed:23749632}.; FUNCTION: Allele B*27:05: Presents to CD8-positive T cells immunodominant viral epitopes derived from HCV POLG (ARMILMTHF), HIV-1 gag (KRWIILGLNK), IAV NP (SRYWAIRTR), SARS-CoV-2 N/nucleoprotein (QRNAPRITF), EBV/HHV-4 EBNA4 (HRCQAIRKK) and EBV/HHV-4 EBNA6 (RRIYDLIEL), confering longterm protection against viral infection (PubMed:19139562, PubMed:18385228, PubMed:15113903, PubMed:9620674, PubMed:32887977). Can present self-peptides derived from cytosolic and nuclear proteins. All peptides carry an Arg at position 2 (PubMed:1922338). The peptide-bound form interacts with NK cell inhibitory receptor KIR3DL1 and inhibits NK cell activation in a peptide-specific way, being particularly sensitive to the nature of the amino acid side chain at position 8 of the antigenic peptide (PubMed:8879234, PubMed:15657948). KIR3DL1 fails to recognize HLA-B*27:05 in complex with B2M and EBV/HHV-4 EBNA6 (RRIYDLIEL) peptide, which can lead to increased activation of NK cells during infection (PubMed:15657948). May present an altered repertoire of peptides in the absence of TAP1-TAP2 and TAPBPL (PubMed:9620674). {ECO:0000269|PubMed:15113903, ECO:0000269|PubMed:15657948, ECO:0000269|PubMed:18385228, ECO:0000269|PubMed:19139562, ECO:0000269|PubMed:1922338, ECO:0000269|PubMed:8879234, ECO:0000269|PubMed:9620674}.; FUNCTION: Allele B*40:01: Presents immunodominant viral epitopes derived from EBV/HHV-4 LMP2 (IEDPPFNSL) and SARS-CoV-2 N/nucleoprotein (MEVTPSGTWL), triggering memory CD8-positive T cell response (PubMed:18991276, PubMed:32887977). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and a Leu anchor residue at the C-terminus (PubMed:18991276). {ECO:0000269|PubMed:18991276, ECO:0000269|PubMed:32887977}.; FUNCTION: Allele B*41:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*44:02: Presents immunodominant viral epitopes derived from EBV/HHV-4 EBNA4 (VEITPYKPTW) and EBNA6 (AEGGVGWRHW, EENLLDFVRF), triggering memory CD8-positive T cell response (PubMed:9620674, PubMed:18991276). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Phe, Tyr or Trp anchor residues at the C-terminus (PubMed:18991276). {ECO:0000269|PubMed:18991276, ECO:0000269|PubMed:9620674}.; FUNCTION: Allele B*45:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*46:01: Preferentially presents nonameric peptides sharing a signature motif, namely Ala and Leu at position 2 and Tyr, Phe, Leu, or Met anchor residues at the C-terminus. The peptide-bound form interacts with KIR2DL3 and inhibits NK cell cytotoxic response in a peptide-specific way. {ECO:0000269|PubMed:28514659}.; FUNCTION: Allele B*47:01: Displays self-peptides sharing a signature motif, namely an Asp at position 2 and Leu or Met anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*49:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ile or Val anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*50:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*51:01: Presents an octomeric HIV-1 epitope derived from gag-pol (TAFTIPSI) to the public TRAV17/TRBV7-3 TCR clonotype, strongly suppressing HIV-1 replication. {ECO:0000269|PubMed:24600035}.; FUNCTION: Allele B*54:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus. {ECO:0000269|PubMed:7743181}.; FUNCTION: Allele B*55:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus. {ECO:0000269|PubMed:7743181}.; FUNCTION: Allele B*56:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus. {ECO:0000269|PubMed:7743181}.; FUNCTION: Allele B*57:01: The peptide-bound form recognizes KIR3DL1 and inhibits NK cell cytotoxic response. Presents HIV gag peptides (immunodominant KAFSPEVIPMF and subdominant KALGPAATL epitopes) predominantly to CD8-positive T cell clones expressing a TRAV41-containing TCR, triggering HLA-B-restricted T cell responses. {ECO:0000269|PubMed:22020283, ECO:0000269|PubMed:25480565, ECO:0000269|PubMed:34228645}.; FUNCTION: Allele B*67:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Leu anchor residue at the C-terminus. {ECO:0000269|PubMed:7743181}.		adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; defense response [GO:0006952]; detection of bacterium [GO:0016045]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; regulation of dendritic cell differentiation [GO:2001198]; regulation of interleukin-12 production [GO:0032655]; regulation of interleukin-6 production [GO:0032675]; regulation of T cell anergy [GO:0002667]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]	peptide antigen binding [GO:0042605]; protein-folding chaperone binding [GO:0051087]; signaling receptor binding [GO:0005102]; TAP binding [GO:0046977]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; peptide antigen binding [GO:0042605]; protein-folding chaperone binding [GO:0051087]; signaling receptor binding [GO:0005102]; TAP binding [GO:0046977]; adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; defense response [GO:0006952]; detection of bacterium [GO:0016045]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; regulation of dendritic cell differentiation [GO:2001198]; regulation of interleukin-12 production [GO:0032655]; regulation of interleukin-6 production [GO:0032675]; regulation of T cell anergy [GO:0002667]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25480565, ECO:0000269|PubMed:26439010, ECO:0000269|PubMed:9620674}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:9620674}; Single-pass type I membrane protein {ECO:0000255}.
P01893	reviewed	HLAH_HUMAN	Putative HLA class I histocompatibility antigen, alpha chain H (HLA-12.4) (HLA-AR) (MHC class I antigen H)	HLA-H HLAH	Homo sapiens (Human)	362	FUNCTION: Involved in the presentation of foreign antigens to the immune system.		antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; early endosome membrane [GO:0031901]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	beta-2-microglobulin binding [GO:0030881]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]	azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; early endosome membrane [GO:0031901]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; beta-2-microglobulin binding [GO:0030881]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P01903	reviewed	DRA_HUMAN	HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)	HLA-DRA HLA-DRA1	Homo sapiens (Human)	254	FUNCTION: An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:17334368, PubMed:8145819, PubMed:15322540, PubMed:22327072, PubMed:27591323, PubMed:31495665, PubMed:15265931, PubMed:9075930, PubMed:24190431). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819). {ECO:0000269|PubMed:15265931, ECO:0000269|PubMed:15322540, ECO:0000269|PubMed:17182262, ECO:0000269|PubMed:17334368, ECO:0000269|PubMed:22327072, ECO:0000269|PubMed:23783831, ECO:0000269|PubMed:24190431, ECO:0000269|PubMed:25413013, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:29884618, ECO:0000269|PubMed:31495665, ECO:0000269|PubMed:8145819, ECO:0000269|PubMed:9075930}.		adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class II [GO:0002491]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002504]; cognition [GO:0050890]; immune response [GO:0006955]; myeloid dendritic cell antigen processing and presentation [GO:0002469]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of immune response [GO:0050778]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; regulation of T-helper cell differentiation [GO:0045622]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; immunological synapse [GO:0001772]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]	MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; polysaccharide binding [GO:0030247]; T cell receptor binding [GO:0042608]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; immunological synapse [GO:0001772]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; polysaccharide binding [GO:0030247]; T cell receptor binding [GO:0042608]; adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class II [GO:0002491]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002504]; cognition [GO:0050890]; immune response [GO:0006955]; myeloid dendritic cell antigen processing and presentation [GO:0002469]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of immune response [GO:0050778]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; regulation of T-helper cell differentiation [GO:0045622]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15322540, ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:29884618}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:19117940}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:19117940, ECO:0000269|PubMed:9075930}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:9075930}; Single-pass type I membrane protein {ECO:0000255}. Autolysosome membrane {ECO:0000269|PubMed:17182262}; Single-pass type I membrane protein. Note=The MHCII complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:9075930, PubMed:18305173). Component of immunological synapses at the interface between T cell and APC (PubMed:15322540, PubMed:29884618). {ECO:0000269|PubMed:15322540, ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:29884618, ECO:0000269|PubMed:9075930}.
P01906	reviewed	DQA2_HUMAN	HLA class II histocompatibility antigen, DQ alpha 2 chain (DX alpha chain) (HLA class II histocompatibility antigen, DQ(6) alpha chain) (HLA-DQA1) (MHC class II DQA2)	HLA-DQA2 HLA-DXA	Homo sapiens (Human)	255	FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. {ECO:0000269|PubMed:22407913}.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]	MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Lysosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
P01909	reviewed	DQA1_HUMAN	HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1)	HLA-DQA1	Homo sapiens (Human)	254	FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]	MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
P01911	reviewed	DRB1_HUMAN	HLA class II histocompatibility antigen, DRB1 beta chain (Human leukocyte antigen DRB1) (HLA-DRB1)	HLA-DRB1	Homo sapiens (Human)	266	FUNCTION: A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:22327072, PubMed:27591323, PubMed:8642306, PubMed:15265931, PubMed:31495665, PubMed:16148104). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819). {ECO:0000269|PubMed:15265931, ECO:0000269|PubMed:17182262, ECO:0000269|PubMed:22327072, ECO:0000269|PubMed:23783831, ECO:0000269|PubMed:25413013, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:29884618, ECO:0000269|PubMed:31495665, ECO:0000269|PubMed:8145819, ECO:0000269|PubMed:8642306}.; FUNCTION: Allele DRB1*01:01: Displays an immunodominant epitope derived from Bacillus anthracis pagA/protective antigen, PA (KLPLYISNPNYKVNVYAVT), to both naive and PA-specific memory CD4-positive T cells (PubMed:22327072). Presents immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (PRFSLPFLSIASAYYMFYDG) and VP2 (PHQFINLRSNNSATLIVPYV), contributing to viral clearance (PubMed:27591323). Displays commonly recognized peptides derived from IAV external protein HA (PKYVKQNTLKLAT and SNGNFIAPEYAYKIVK) and from internal proteins M, NP and PB1, with M-derived epitope (GLIYNRMGAVTTEV) being the most immunogenic (PubMed:8145819, PubMed:9075930, PubMed:25413013, PubMed:32668259). Presents a self-peptide derived from COL4A3 (GWISLWKGFSF) to TCR (TRAV14 biased) on CD4-positive, FOXP3-positive regulatory T cells and mediates immune tolerance to self (PubMed:28467828). May present peptides derived from oncofetal trophoblast glycoprotein TPBG 5T4, known to be recognized by both T-helper 1 and regulatory T cells (PubMed:31619516). Displays with low affinity a self-peptide derived from MBP (VHFFKNIVTPRTP) (PubMed:9075930). {ECO:0000269|PubMed:22327072, ECO:0000269|PubMed:25413013, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:28467828, ECO:0000269|PubMed:29884618, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:32668259, ECO:0000269|PubMed:8145819, ECO:0000269|PubMed:9075930}.; FUNCTION: Allele DRB1*03:01: May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN), contributing to viral clearance (PubMed:27591323). Displays self-peptides derived from retinal SAG (NRERRGIALDGKIKHE) and thyroid TG (LSSVVVDPSIRHFDV) (PubMed:25413013). Presents viral epitopes derived from HHV-6B gH/U48 and U85 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). Presents several immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a role in immune recognition and long-term protection (PubMed:19830726). {ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:25413013, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:31020640}.; FUNCTION: Allele DRB1*04:01: Presents an immunodominant bacterial epitope derived from M. tuberculosis esxB/culture filtrate antigen CFP-10 (EISTNIRQAGVQYSR), eliciting CD4-positive T cell effector functions such as IFNG production and cytotoxic activity (PubMed:15265931). May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN), contributing to viral clearance (PubMed:27591323). Presents tumor epitopes derived from melanoma-associated TYR antigen (QNILLSNAPLGPQFP and DYSYLQDSDPDSFQD), triggering CD4-positive T cell effector functions such as GMCSF production (PubMed:8642306). Displays preferentially citrullinated self-peptides derived from VIM (GVYATR/citSSAVR and SAVRAR/citSSVPGVR) and ACAN (VVLLVATEGR/ CitVRVNSAYQDK) (PubMed:24190431). Displays self-peptides derived from COL2A1 (PubMed:9354468). {ECO:0000269|PubMed:15265931, ECO:0000269|PubMed:24190431, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:8642306, ECO:0000269|PubMed:9354468}.; FUNCTION: Allele DRB1*04:02: Displays native or citrullinated self-peptides derived from VIM. {ECO:0000269|PubMed:24190431}.; FUNCTION: Allele DRB1*04:04: May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (HIVMQYMYVPPGAPIPTTRN) and VP2 (RGDSTITSQDVANAVVGYGV), contributing to viral clearance (PubMed:27591323). Displays preferentially citrullinated self-peptides derived from VIM (SAVRAR/citSSVPGVR) (PubMed:24190431). {ECO:0000269|PubMed:24190431, ECO:0000269|PubMed:27591323}.; FUNCTION: Allele DRB1*04:05: May present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies. {ECO:0000269|PubMed:19120973}.; FUNCTION: Allele DRB1*05:01: Presents an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load. {ECO:0000269|PubMed:29884618}.; FUNCTION: Allele DRB1*07:01: Upon EBV infection, presents latent antigen EBNA2 peptide (PRSPTVFYNIPPMPLPPSQL) to CD4-positive T cells, driving oligoclonal expansion and selection of a dominant virus-specific memory T cell subset with cytotoxic potential to directly eliminate virus-infected B cells (PubMed:31308093). May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (PRFSLPFLSIASAYYMFYDG) and VP2 (VPYVNAVPMDSMVRHNNWSL), contributing to viral clearance (PubMed:27591323). In the context of tumor immunesurveillance, may present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (MTEYKLVVVGAVGVGKSALTIQLI), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:22929521). In metastatic epithelial tumors, presents to intratumoral CD4-positive T cells a KRAS neoantigen (MTEYKLVVVGAVGVGKSALTIQLI) carrying G12V hotspot driver mutation and may mediate tumor regression (PubMed:30282837). {ECO:0000269|PubMed:22929521, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:30282837, ECO:0000269|PubMed:31308093}.; FUNCTION: Allele DRB1*11:01: Displays an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (SDRIIQITRGDSTITSQDVA), contributing to viral clearance (PubMed:27591323). Presents several immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a role in immune recognition and longterm protection (PubMed:19830726). In the context of tumor immunesurveillance, may present tumor-derived neoantigens to CD4-positive T cells and trigger anti-tumor helper functions (PubMed:31495665). {ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:29884618, ECO:0000269|PubMed:31495665}.; FUNCTION: Allele DRB1*13:01: Presents viral epitopes derived from HHV-6B antigens to polyfunctional CD4-positive T cells implicated in control of HHV-6B infection. {ECO:0000269|PubMed:31020640}.; FUNCTION: Allele DRB1*15:01: May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (SNNSATLIVPYVNAVPMDSM), contributing to viral clearance (PubMed:27591323). Displays a self-peptide derived from MBP (ENPVVHFFKNIVTPR) (PubMed:9782128, PubMed:25413013). May present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies. {ECO:0000269|PubMed:19120973, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:9782128}.; FUNCTION: Allele DRB1*15:02: Displays an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:19120973). {ECO:0000269|PubMed:19120973, ECO:0000269|PubMed:29884618}.; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus on lymphocytes. {ECO:0000269|PubMed:11864610, ECO:0000269|PubMed:9151859}.		antigen processing and presentation of endogenous peptide antigen via MHC class II [GO:0002491]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; detection of bacterium [GO:0016045]; epidermis development [GO:0008544]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; macrophage differentiation [GO:0030225]; myeloid dendritic cell antigen processing and presentation [GO:0002469]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type II interferon production [GO:0032689]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immune response [GO:0050778]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; positive regulation of viral entry into host cell [GO:0046598]; protein tetramerization [GO:0051262]; regulation of interleukin-10 production [GO:0032653]; regulation of interleukin-4 production [GO:0032673]; regulation of T-helper cell differentiation [GO:0045622]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; immunological synapse [GO:0001772]; intermediate filament [GO:0005882]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]	CD4 receptor binding [GO:0042609]; MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; polysaccharide binding [GO:0030247]; structural constituent of cytoskeleton [GO:0005200]; T cell receptor binding [GO:0042608]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; immunological synapse [GO:0001772]; intermediate filament [GO:0005882]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; CD4 receptor binding [GO:0042609]; MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; polysaccharide binding [GO:0030247]; structural constituent of cytoskeleton [GO:0005200]; T cell receptor binding [GO:0042608]; antigen processing and presentation of endogenous peptide antigen via MHC class II [GO:0002491]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; detection of bacterium [GO:0016045]; epidermis development [GO:0008544]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; macrophage differentiation [GO:0030225]; myeloid dendritic cell antigen processing and presentation [GO:0002469]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type II interferon production [GO:0032689]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immune response [GO:0050778]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; positive regulation of viral entry into host cell [GO:0046598]; protein tetramerization [GO:0051262]; regulation of interleukin-10 production [GO:0032653]; regulation of interleukin-4 production [GO:0032673]; regulation of T-helper cell differentiation [GO:0045622]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:29884618}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:9075930}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:9075930}; Single-pass type I membrane protein {ECO:0000255}. Autolysosome membrane {ECO:0000269|PubMed:17182262}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:18305173). Component of immunological synapses at the interface between T cell and APC (PubMed:29884618). {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:29884618}.
P01920	reviewed	DQB1_HUMAN	HLA class II histocompatibility antigen, DQ beta 1 chain (MHC class II antigen DQB1)	HLA-DQB1 HLA-DQB	Homo sapiens (Human)	261	FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; humoral immune response [GO:0006959]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; T cell receptor signaling pathway [GO:0050852]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]	MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; humoral immune response [GO:0006959]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
P02008	reviewed	HBAZ_HUMAN	Hemoglobin subunit zeta (HBAZ) (Hemoglobin zeta chain) (Zeta-globin)	HBZ HBZ2	Homo sapiens (Human)	142	FUNCTION: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.		carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]	extracellular exosome [GO:0070062]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]	extracellular exosome [GO:0070062]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]	
P02042	reviewed	HBD_HUMAN	Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain)	HBD	Homo sapiens (Human)	147	FUNCTION: Involved in oxygen transport from the lung to the various peripheral tissues.		carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]	blood microparticle [GO:0072562]; cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]	heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]	blood microparticle [GO:0072562]; cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]	
P02100	reviewed	HBE_HUMAN	Hemoglobin subunit epsilon (Epsilon-globin) (Hemoglobin epsilon chain)	HBE1 HBE	Homo sapiens (Human)	147	FUNCTION: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.		carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]; response to organic cyclic compound [GO:0014070]	blood microparticle [GO:0072562]; cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]	heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; protein-containing complex binding [GO:0044877]	blood microparticle [GO:0072562]; cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; protein-containing complex binding [GO:0044877]; carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]; response to organic cyclic compound [GO:0014070]	
P02144	reviewed	MYG_HUMAN	Myoglobin	MB	Homo sapiens (Human)	154	FUNCTION: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.		brown fat cell differentiation [GO:0050873]; enucleate erythrocyte differentiation [GO:0043353]; heart development [GO:0007507]; hydrogen peroxide mediated signaling pathway [GO:0071588]; oxygen transport [GO:0015671]; response to hypoxia [GO:0001666]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; brown fat cell differentiation [GO:0050873]; enucleate erythrocyte differentiation [GO:0043353]; heart development [GO:0007507]; hydrogen peroxide mediated signaling pathway [GO:0071588]; oxygen transport [GO:0015671]; response to hypoxia [GO:0001666]	
P02452	reviewed	CO1A1_HUMAN	Collagen alpha-1(I) chain (Alpha-1 type I collagen)	COL1A1	Homo sapiens (Human)	1464	FUNCTION: Type I collagen is a member of group I collagen (fibrillar forming collagen).		blood vessel development [GO:0001568]; bone trabecula formation [GO:0060346]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to amino acid stimulus [GO:0071230]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to fluoride [GO:1902618]; cellular response to mechanical stimulus [GO:0071260]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin E [GO:0071306]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; embryonic skeletal system development [GO:0048706]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; intramembranous ossification [GO:0001957]; negative regulation of cell-substrate adhesion [GO:0010812]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; protein localization to nucleus [GO:0034504]; protein transport [GO:0015031]; response to cAMP [GO:0051591]; response to estradiol [GO:0032355]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to insulin [GO:0032868]; response to mechanical stimulus [GO:0009612]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; skin development [GO:0043588]; skin morphogenesis [GO:0043589]; tooth mineralization [GO:0034505]; visual perception [GO:0007601]	collagen type I trimer [GO:0005584]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; protease binding [GO:0002020]	collagen type I trimer [GO:0005584]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; protease binding [GO:0002020]; blood vessel development [GO:0001568]; bone trabecula formation [GO:0060346]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to amino acid stimulus [GO:0071230]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to fluoride [GO:1902618]; cellular response to mechanical stimulus [GO:0071260]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin E [GO:0071306]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; embryonic skeletal system development [GO:0048706]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; intramembranous ossification [GO:0001957]; negative regulation of cell-substrate adhesion [GO:0010812]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; protein localization to nucleus [GO:0034504]; protein transport [GO:0015031]; response to cAMP [GO:0051591]; response to estradiol [GO:0032355]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to insulin [GO:0032868]; response to mechanical stimulus [GO:0009612]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; skin development [GO:0043588]; skin morphogenesis [GO:0043589]; tooth mineralization [GO:0034505]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
P02458	reviewed	CO2A1_HUMAN	Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]	COL2A1	Homo sapiens (Human)	1487	FUNCTION: Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.		anterior head development [GO:0097065]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to BMP stimulus [GO:0071773]; central nervous system development [GO:0007417]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; embryonic skeletal joint morphogenesis [GO:0060272]; endochondral ossification [GO:0001958]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; limb bud formation [GO:0060174]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; notochord development [GO:0030903]; otic vesicle development [GO:0071599]; proteoglycan metabolic process [GO:0006029]; regulation of gene expression [GO:0010468]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; tissue homeostasis [GO:0001894]; visual perception [GO:0007601]	basement membrane [GO:0005604]; collagen type II trimer [GO:0005585]; collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]; MHC class II protein binding [GO:0042289]; platelet-derived growth factor binding [GO:0048407]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]	basement membrane [GO:0005604]; collagen type II trimer [GO:0005585]; collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]; MHC class II protein binding [GO:0042289]; platelet-derived growth factor binding [GO:0048407]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; anterior head development [GO:0097065]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to BMP stimulus [GO:0071773]; central nervous system development [GO:0007417]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; embryonic skeletal joint morphogenesis [GO:0060272]; endochondral ossification [GO:0001958]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; limb bud formation [GO:0060174]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; notochord development [GO:0030903]; otic vesicle development [GO:0071599]; proteoglycan metabolic process [GO:0006029]; regulation of gene expression [GO:0010468]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; tissue homeostasis [GO:0001894]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
P02461	reviewed	CO3A1_HUMAN	Collagen alpha-1(III) chain	COL3A1	Homo sapiens (Human)	1466	FUNCTION: Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.		aorta smooth muscle tissue morphogenesis [GO:0060414]; basement membrane organization [GO:0071711]; cell-matrix adhesion [GO:0007160]; cellular response to amino acid stimulus [GO:0071230]; cerebral cortex development [GO:0021987]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; digestive tract development [GO:0048565]; elastic fiber assembly [GO:0048251]; endochondral bone morphogenesis [GO:0060350]; extracellular matrix organization [GO:0030198]; fibroblast proliferation [GO:0048144]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; layer formation in cerebral cortex [GO:0021819]; limb joint morphogenesis [GO:0036022]; lung development [GO:0030324]; multicellular organism growth [GO:0035264]; negative regulation of immune response [GO:0050777]; negative regulation of neuron migration [GO:2001223]; neuron migration [GO:0001764]; peptide cross-linking [GO:0018149]; platelet activation [GO:0030168]; positive regulation of Rho protein signal transduction [GO:0035025]; response to angiotensin [GO:1990776]; response to cytokine [GO:0034097]; response to radiation [GO:0009314]; skin development [GO:0043588]; supramolecular fiber organization [GO:0097435]; tissue homeostasis [GO:0001894]; transforming growth factor beta receptor signaling pathway [GO:0007179]; transforming growth factor beta1 production [GO:0032905]; wound healing [GO:0042060]	collagen type III trimer [GO:0005586]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; protease binding [GO:0002020]; SMAD binding [GO:0046332]	collagen type III trimer [GO:0005586]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; protease binding [GO:0002020]; SMAD binding [GO:0046332]; aorta smooth muscle tissue morphogenesis [GO:0060414]; basement membrane organization [GO:0071711]; cell-matrix adhesion [GO:0007160]; cellular response to amino acid stimulus [GO:0071230]; cerebral cortex development [GO:0021987]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; digestive tract development [GO:0048565]; elastic fiber assembly [GO:0048251]; endochondral bone morphogenesis [GO:0060350]; extracellular matrix organization [GO:0030198]; fibroblast proliferation [GO:0048144]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; layer formation in cerebral cortex [GO:0021819]; limb joint morphogenesis [GO:0036022]; lung development [GO:0030324]; multicellular organism growth [GO:0035264]; negative regulation of immune response [GO:0050777]; negative regulation of neuron migration [GO:2001223]; neuron migration [GO:0001764]; peptide cross-linking [GO:0018149]; platelet activation [GO:0030168]; positive regulation of Rho protein signal transduction [GO:0035025]; response to angiotensin [GO:1990776]; response to cytokine [GO:0034097]; response to radiation [GO:0009314]; skin development [GO:0043588]; supramolecular fiber organization [GO:0097435]; tissue homeostasis [GO:0001894]; transforming growth factor beta receptor signaling pathway [GO:0007179]; transforming growth factor beta1 production [GO:0032905]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
P02462	reviewed	CO4A1_HUMAN	Collagen alpha-1(IV) chain [Cleaved into: Arresten]	COL4A1	Homo sapiens (Human)	1669	FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. {ECO:0000250|UniProtKB:P02463}.; FUNCTION: Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. {ECO:0000269|PubMed:10811134, ECO:0000269|PubMed:18775695}.		basement membrane organization [GO:0071711]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; branching involved in blood vessel morphogenesis [GO:0001569]; cellular response to amino acid stimulus [GO:0071230]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; epithelial cell differentiation [GO:0030855]; extracellular matrix organization [GO:0030198]; neuromuscular junction development [GO:0007528]; renal tubule morphogenesis [GO:0061333]; retinal blood vessel morphogenesis [GO:0061304]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; platelet-derived growth factor binding [GO:0048407]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; platelet-derived growth factor binding [GO:0048407]; basement membrane organization [GO:0071711]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; branching involved in blood vessel morphogenesis [GO:0001569]; cellular response to amino acid stimulus [GO:0071230]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; epithelial cell differentiation [GO:0030855]; extracellular matrix organization [GO:0030198]; neuromuscular junction development [GO:0007528]; renal tubule morphogenesis [GO:0061333]; retinal blood vessel morphogenesis [GO:0061304]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:P02463}.
P02489	reviewed	CRYAA_HUMAN	Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4) [Cleaved into: Alpha-crystallin A(1-172); Alpha-crystallin A(1-168); Alpha-crystallin A(1-162)]	CRYAA CRYA1 HSPB4	Homo sapiens (Human)	173	FUNCTION: Contributes to the transparency and refractive index of the lens (PubMed:18302245). In its oxidized form (absence of intramolecular disulfide bond), acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions (PubMed:22120592, PubMed:31792453, PubMed:18199971, PubMed:19595763). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:28935373). {ECO:0000269|PubMed:18199971, ECO:0000269|PubMed:19595763, ECO:0000269|PubMed:22120592, ECO:0000269|PubMed:28935373, ECO:0000269|PubMed:31792453, ECO:0000303|PubMed:18302245}.		lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intracellular transport [GO:0032387]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; structural constituent of eye lens [GO:0005212]; structural molecule activity [GO:0005198]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; structural constituent of eye lens [GO:0005212]; structural molecule activity [GO:0005198]; unfolded protein binding [GO:0051082]; lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intracellular transport [GO:0032387]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14512969, ECO:0000269|PubMed:19464326, ECO:0000269|PubMed:19503744, ECO:0000269|PubMed:26004348, ECO:0000269|PubMed:30340470}. Nucleus {ECO:0000269|PubMed:19464326}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
P02511	reviewed	CRYAB_HUMAN	Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)	CRYAB CRYA2 HSPB5	Homo sapiens (Human)	175	FUNCTION: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:P23927}.		apoptotic process involved in morphogenesis [GO:0060561]; cellular response to gamma radiation [GO:0071480]; lens development in camera-type eye [GO:0002088]; microtubule polymerization or depolymerization [GO:0031109]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of intracellular transport [GO:0032387]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; protein folding [GO:0006457]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; regulation of programmed cell death [GO:0043067]; response to estradiol [GO:0032355]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; stress-activated MAPK cascade [GO:0051403]; tubulin complex assembly [GO:0007021]	actin filament bundle [GO:0032432]; axon [GO:0030424]; cardiac myofibril [GO:0097512]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]; synaptic membrane [GO:0097060]; Z disc [GO:0030018]	amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; structural constituent of eye lens [GO:0005212]; structural molecule activity [GO:0005198]; unfolded protein binding [GO:0051082]	actin filament bundle [GO:0032432]; axon [GO:0030424]; cardiac myofibril [GO:0097512]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]; synaptic membrane [GO:0097060]; Z disc [GO:0030018]; amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; structural constituent of eye lens [GO:0005212]; structural molecule activity [GO:0005198]; unfolded protein binding [GO:0051082]; apoptotic process involved in morphogenesis [GO:0060561]; cellular response to gamma radiation [GO:0071480]; lens development in camera-type eye [GO:0002088]; microtubule polymerization or depolymerization [GO:0031109]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of intracellular transport [GO:0032387]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; protein folding [GO:0006457]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; regulation of programmed cell death [GO:0043067]; response to estradiol [GO:0032355]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; stress-activated MAPK cascade [GO:0051403]; tubulin complex assembly [GO:0007021]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326, ECO:0000269|PubMed:28493373}. Nucleus {ECO:0000269|PubMed:19464326}. Secreted {ECO:0000269|PubMed:32272059}. Lysosome {ECO:0000250|UniProtKB:P23927}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326). Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373). Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). {ECO:0000269|PubMed:19464326, ECO:0000269|PubMed:28493373, ECO:0000269|PubMed:32272059}.
P02533	reviewed	K1C14_HUMAN	Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14)	KRT14	Homo sapiens (Human)	472	FUNCTION: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. {ECO:0000269|PubMed:11724817}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; hair cycle [GO:0042633]; intermediate filament bundle assembly [GO:0045110]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; stem cell differentiation [GO:0048863]	basal part of cell [GO:0045178]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; nucleus [GO:0005634]	keratin filament binding [GO:1990254]; structural constituent of cytoskeleton [GO:0005200]	basal part of cell [GO:0045178]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; nucleus [GO:0005634]; keratin filament binding [GO:1990254]; structural constituent of cytoskeleton [GO:0005200]; epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; hair cycle [GO:0042633]; intermediate filament bundle assembly [GO:0045110]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11724817, ECO:0000269|PubMed:31995743, ECO:0000269|PubMed:32179842}. Nucleus {ECO:0000269|PubMed:11724817}. Note=Expressed in both as a filamentous pattern. {ECO:0000269|PubMed:11724817}.
P02538	reviewed	K2C6A_HUMAN	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5)	KRT6A K6A KRT6D	Homo sapiens (Human)	564	FUNCTION: Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. {ECO:0000250|UniProtKB:P50446}.	MISCELLANEOUS: There are at least six isoforms of human type II keratin-6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.; MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell differentiation [GO:0030154]; defense response to Gram-positive bacterium [GO:0050830]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; killing of cells of another organism [GO:0031640]; morphogenesis of an epithelium [GO:0002009]; negative regulation of entry of bacterium into host cell [GO:2000536]; positive regulation of cell population proliferation [GO:0008284]; wound healing [GO:0042060]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634]	structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell differentiation [GO:0030154]; defense response to Gram-positive bacterium [GO:0050830]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; killing of cells of another organism [GO:0031640]; morphogenesis of an epithelium [GO:0002009]; negative regulation of entry of bacterium into host cell [GO:2000536]; positive regulation of cell population proliferation [GO:0008284]; wound healing [GO:0042060]	
P02545	reviewed	LMNA_HUMAN	Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]	LMNA LMN1	Homo sapiens (Human)	664	FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:23666920, PubMed:18611980). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:31548606}.; FUNCTION: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence. {ECO:0000269|PubMed:20458013}.	MISCELLANEOUS: There are three types of lamins in human cells: A, B, and C.; MISCELLANEOUS: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.; MISCELLANEOUS: [Isoform 6]: Disease-associated isoform. Polymorphism at codon 608 results in activation of a cryptic splice donor site within exon 11, resulting in a truncated protein product that lacks the site for endoproteolytic cleavage. {ECO:0000305}.	cellular response to hypoxia [GO:0071456]; cellular senescence [GO:0090398]; DNA double-strand break attachment to nuclear envelope [GO:1990683]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; heterochromatin formation [GO:0031507]; muscle organ development [GO:0007517]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; positive regulation of gene expression [GO:0010628]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein localization to nuclear envelope [GO:0090435]; protein localization to nucleus [GO:0034504]; regulation of cell migration [GO:0030334]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein stability [GO:0031647]; regulation of telomere maintenance [GO:0032204]; ventricular cardiac muscle cell development [GO:0055015]	cytosol [GO:0005829]; intermediate filament [GO:0005882]; lamin filament [GO:0005638]; nuclear envelope [GO:0005635]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; site of double-strand break [GO:0035861]	identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]	cytosol [GO:0005829]; intermediate filament [GO:0005882]; lamin filament [GO:0005638]; nuclear envelope [GO:0005635]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; site of double-strand break [GO:0035861]; identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; cellular response to hypoxia [GO:0071456]; cellular senescence [GO:0090398]; DNA double-strand break attachment to nuclear envelope [GO:1990683]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; heterochromatin formation [GO:0031507]; muscle organ development [GO:0007517]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; positive regulation of gene expression [GO:0010628]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein localization to nuclear envelope [GO:0090435]; protein localization to nucleus [GO:0034504]; regulation of cell migration [GO:0030334]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein stability [GO:0031647]; regulation of telomere maintenance [GO:0032204]; ventricular cardiac muscle cell development [GO:0055015]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15372542, ECO:0000269|PubMed:31548606}. Nucleus envelope {ECO:0000269|PubMed:29599122}. Nucleus lamina {ECO:0000305|PubMed:10080180}. Nucleus, nucleoplasm. Nucleus matrix {ECO:0000269|PubMed:31548606}. Note=Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleavage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina (PubMed:15317753). EMD is required for proper localization of non-farnesylated prelamin-A/C (PubMed:19323649). {ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:19323649}.; SUBCELLULAR LOCATION: [Isoform C]: Nucleus speckle {ECO:0000269|PubMed:16061563}.
P02549	reviewed	SPTA1_HUMAN	Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin)	SPTA1 SPTA	Homo sapiens (Human)	2419	FUNCTION: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.	MISCELLANEOUS: This complex is anchored to the cytoplasmic face of the plasma membrane via another protein, ankyrin, which binds to beta-spectrin and mediates the binding of the whole complex to a transmembrane protein band 3. The interaction of erythrocyte spectrin with other proteins through specific binding domains lead to the formation of an extensive subplasmalemmal meshwork which is thought to be responsible for the maintenance of the biconcave shape of human erythrocytes, for the regulation of plasma membrane components and for the maintenance of the lipid asymmetry of the plasma membrane.	actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; actin filament organization [GO:0007015]; hemopoiesis [GO:0030097]; lymphocyte homeostasis [GO:0002260]; plasma membrane organization [GO:0007009]; porphyrin-containing compound biosynthetic process [GO:0006779]; positive regulation of T cell proliferation [GO:0042102]; regulation of cell shape [GO:0008360]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cuticular plate [GO:0032437]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cuticular plate [GO:0032437]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; structural constituent of cytoskeleton [GO:0005200]; actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; actin filament organization [GO:0007015]; hemopoiesis [GO:0030097]; lymphocyte homeostasis [GO:0002260]; plasma membrane organization [GO:0007009]; porphyrin-containing compound biosynthetic process [GO:0006779]; positive regulation of T cell proliferation [GO:0042102]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
P02585	reviewed	TNNC2_HUMAN	Troponin C, skeletal muscle	TNNC2	Homo sapiens (Human)	160	FUNCTION: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. {ECO:0000269|PubMed:33755597}.	MISCELLANEOUS: Skeletal muscle troponin C binds four calcium ions.	regulation of muscle contraction [GO:0006937]; skeletal muscle contraction [GO:0003009]	cytosol [GO:0005829]; troponin complex [GO:0005861]	calcium ion binding [GO:0005509]	cytosol [GO:0005829]; troponin complex [GO:0005861]; calcium ion binding [GO:0005509]; regulation of muscle contraction [GO:0006937]; skeletal muscle contraction [GO:0003009]	
P02647	reviewed	APOA1_HUMAN	Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]	APOA1	Homo sapiens (Human)	267	FUNCTION: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}.		adrenal gland development [GO:0030325]; blood vessel endothelial cell migration [GO:0043534]; cholesterol biosynthetic process [GO:0006695]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; glucocorticoid metabolic process [GO:0008211]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; integrin-mediated signaling pathway [GO:0007229]; lipid storage [GO:0019915]; lipoprotein biosynthetic process [GO:0042158]; negative chemotaxis [GO:0050919]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; peptidyl-methionine modification [GO:0018206]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of hydrolase activity [GO:0051345]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein oxidation [GO:0018158]; protein stabilization [GO:0050821]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of intestinal cholesterol absorption [GO:0030300]; regulation of protein phosphorylation [GO:0001932]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; vitamin transport [GO:0051180]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; high-density lipoprotein particle [GO:0034364]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361]	amyloid-beta binding [GO:0001540]; apolipoprotein A-I receptor binding [GO:0034191]; apolipoprotein receptor binding [GO:0034190]; chemorepellent activity [GO:0045499]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor binding [GO:0070653]; identical protein binding [GO:0042802]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; high-density lipoprotein particle [GO:0034364]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361]; amyloid-beta binding [GO:0001540]; apolipoprotein A-I receptor binding [GO:0034191]; apolipoprotein receptor binding [GO:0034190]; chemorepellent activity [GO:0045499]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor binding [GO:0070653]; identical protein binding [GO:0042802]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; adrenal gland development [GO:0030325]; blood vessel endothelial cell migration [GO:0043534]; cholesterol biosynthetic process [GO:0006695]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; glucocorticoid metabolic process [GO:0008211]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; integrin-mediated signaling pathway [GO:0007229]; lipid storage [GO:0019915]; lipoprotein biosynthetic process [GO:0042158]; negative chemotaxis [GO:0050919]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; peptidyl-methionine modification [GO:0018206]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of hydrolase activity [GO:0051345]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein oxidation [GO:0018158]; protein stabilization [GO:0050821]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of intestinal cholesterol absorption [GO:0030300]; regulation of protein phosphorylation [GO:0001932]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; vitamin transport [GO:0051180]	SUBCELLULAR LOCATION: Secreted.
P02649	reviewed	APOE_HUMAN	Apolipoprotein E (Apo-E)	APOE	Homo sapiens (Human)	317	FUNCTION: APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (PubMed:6860692, PubMed:1911868, PubMed:14754908). APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance (PubMed:6860692, PubMed:2762297, PubMed:1911868, PubMed:1917954, PubMed:9395455, PubMed:14754908, PubMed:23620513). Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma (PubMed:6860692, PubMed:2762297, PubMed:9395455). As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL) (PubMed:6860692, PubMed:1911868). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles (PubMed:2762297, PubMed:1917954, PubMed:7768901, PubMed:8939961, PubMed:12950167, PubMed:20030366, PubMed:2063194, PubMed:8756331, PubMed:20303980, PubMed:1530612, PubMed:7635945). Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells (PubMed:9395455, PubMed:9488694, PubMed:23676495, PubMed:7635945). A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes (PubMed:1911868, PubMed:1917954, PubMed:9395455, PubMed:23676495, PubMed:29516132). APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues (PubMed:2762297, PubMed:29516132). By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis (PubMed:2762297, PubMed:1917954, PubMed:29516132). APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis (PubMed:9395455, PubMed:14754908, PubMed:23620513). First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues (PubMed:14754908, PubMed:23620513). Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes (PubMed:9395455). APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting (PubMed:8939961, PubMed:25173806). APOE is also involved in innate and adaptive immune responses, controlling for instance the survival of myeloid-derived suppressor cells (By similarity). Binds to the immune cell receptor LILRB4 (PubMed:30333625). APOE may also play a role in transcription regulation through a receptor-dependent and cholesterol-independent mechanism, that activates MAP3K12 and a non-canonical MAPK signal transduction pathway that results in enhanced AP-1-mediated transcription of APP (PubMed:28111074). {ECO:0000250|UniProtKB:P08226, ECO:0000269|PubMed:12950167, ECO:0000269|PubMed:14754908, ECO:0000269|PubMed:1530612, ECO:0000269|PubMed:1911868, ECO:0000269|PubMed:1917954, ECO:0000269|PubMed:20030366, ECO:0000269|PubMed:20303980, ECO:0000269|PubMed:2063194, ECO:0000269|PubMed:23620513, ECO:0000269|PubMed:23676495, ECO:0000269|PubMed:2762297, ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:30333625, ECO:0000269|PubMed:6860692, ECO:0000269|PubMed:7635945, ECO:0000269|PubMed:7768901, ECO:0000269|PubMed:8756331, ECO:0000269|PubMed:8939961, ECO:0000269|PubMed:9395455, ECO:0000269|PubMed:9488694, ECO:0000303|PubMed:25173806, ECO:0000303|PubMed:29516132}.; FUNCTION: (Microbial infection) Through its interaction with HCV envelope glycoprotein E2, participates in the attachment of HCV to HSPGs and other receptors (LDLr, VLDLr, and SR-B1) on the cell surface and to the assembly, maturation and infectivity of HCV viral particles (PubMed:25122793, PubMed:29695434). This interaction is probably promoted via the up-regulation of cellular autophagy by the virus (PubMed:29695434). {ECO:0000269|PubMed:25122793, ECO:0000269|PubMed:29695434}.	MISCELLANEOUS: Binds to and activates LILRB4 on acute myeloid leukemia (AML) cells which leads to suppression of T cell proliferation and promotion of AML cell migration and infiltration. {ECO:0000269|PubMed:30333625}.	AMPA glutamate receptor clustering [GO:0097113]; amyloid precursor protein metabolic process [GO:0042982]; artery morphogenesis [GO:0048844]; cGMP-mediated signaling [GO:0019934]; cholesterol catabolic process [GO:0006707]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; chylomicron remnant clearance [GO:0034382]; cytoskeleton organization [GO:0007010]; fatty acid homeostasis [GO:0055089]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; intermediate-density lipoprotein particle clearance [GO:0071831]; intracellular calcium ion homeostasis [GO:0006874]; intracellular transport [GO:0046907]; lipid transport involved in lipid storage [GO:0010877]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein catabolic process [GO:0042159]; locomotory exploration behavior [GO:0035641]; long-chain fatty acid transport [GO:0015909]; long-term memory [GO:0007616]; low-density lipoprotein particle remodeling [GO:0034374]; maintenance of location in cell [GO:0051651]; melanosome organization [GO:0032438]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of blood coagulation [GO:0030195]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron projection development [GO:0010977]; negative regulation of platelet activation [GO:0010544]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of protein secretion [GO:0050709]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of triglyceride metabolic process [GO:0090209]; neuron projection development [GO:0031175]; nitric oxide mediated signal transduction [GO:0007263]; NMDA glutamate receptor clustering [GO:0097114]; phospholipid efflux [GO:0033700]; positive regulation by host of viral process [GO:0044794]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endocytosis [GO:0045807]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heparan sulfate proteoglycan binding [GO:1905860]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of lipid transport across blood-brain barrier [GO:1903002]; positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neuron projection development [GO:0010976]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phospholipid efflux [GO:1902995]; protein import [GO:0017038]; receptor-mediated endocytosis [GO:0006898]; regulation of amyloid fibril formation [GO:1905906]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of amyloid-beta clearance [GO:1900221]; regulation of axon extension [GO:0030516]; regulation of behavioral fear response [GO:2000822]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of cellular response to very-low-density lipoprotein particle stimulus [GO:1905890]; regulation of cholesterol metabolic process [GO:0090181]; regulation of innate immune response [GO:0045088]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein metabolic process [GO:0051246]; regulation of protein-containing complex assembly [GO:0043254]; response to caloric restriction [GO:0061771]; response to dietary excess [GO:0002021]; response to reactive oxygen species [GO:0000302]; reverse cholesterol transport [GO:0043691]; synaptic transmission, cholinergic [GO:0007271]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; triglyceride-rich lipoprotein particle clearance [GO:0071830]; vasodilation [GO:0042311]; very-low-density lipoprotein particle clearance [GO:0034447]; very-low-density lipoprotein particle remodeling [GO:0034372]; virion assembly [GO:0019068]	blood microparticle [GO:0072562]; chylomicron [GO:0042627]; chylomicron remnant [GO:0034360]; clathrin-coated endocytic vesicle membrane [GO:0030669]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; discoidal high-density lipoprotein particle [GO:0034365]; early endosome [GO:0005769]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; high-density lipoprotein particle [GO:0034364]; intermediate-density lipoprotein particle [GO:0034363]; lipoprotein particle [GO:1990777]; low-density lipoprotein particle [GO:0034362]; melanosome [GO:0042470]; membrane [GO:0016020]; multivesicular body, internal vesicle [GO:0097487]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; very-low-density lipoprotein particle [GO:0034361]	amyloid-beta binding [GO:0001540]; antioxidant activity [GO:0016209]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle receptor binding [GO:0050750]; metal chelating activity [GO:0046911]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; very-low-density lipoprotein particle receptor binding [GO:0070326]	blood microparticle [GO:0072562]; chylomicron [GO:0042627]; chylomicron remnant [GO:0034360]; clathrin-coated endocytic vesicle membrane [GO:0030669]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; discoidal high-density lipoprotein particle [GO:0034365]; early endosome [GO:0005769]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; high-density lipoprotein particle [GO:0034364]; intermediate-density lipoprotein particle [GO:0034363]; lipoprotein particle [GO:1990777]; low-density lipoprotein particle [GO:0034362]; melanosome [GO:0042470]; membrane [GO:0016020]; multivesicular body, internal vesicle [GO:0097487]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; very-low-density lipoprotein particle [GO:0034361]; amyloid-beta binding [GO:0001540]; antioxidant activity [GO:0016209]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle receptor binding [GO:0050750]; metal chelating activity [GO:0046911]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; very-low-density lipoprotein particle receptor binding [GO:0070326]; AMPA glutamate receptor clustering [GO:0097113]; amyloid precursor protein metabolic process [GO:0042982]; artery morphogenesis [GO:0048844]; cGMP-mediated signaling [GO:0019934]; cholesterol catabolic process [GO:0006707]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; chylomicron remnant clearance [GO:0034382]; cytoskeleton organization [GO:0007010]; fatty acid homeostasis [GO:0055089]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; intermediate-density lipoprotein particle clearance [GO:0071831]; intracellular calcium ion homeostasis [GO:0006874]; intracellular transport [GO:0046907]; lipid transport involved in lipid storage [GO:0010877]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein catabolic process [GO:0042159]; locomotory exploration behavior [GO:0035641]; long-chain fatty acid transport [GO:0015909]; long-term memory [GO:0007616]; low-density lipoprotein particle remodeling [GO:0034374]; maintenance of location in cell [GO:0051651]; melanosome organization [GO:0032438]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of blood coagulation [GO:0030195]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron projection development [GO:0010977]; negative regulation of platelet activation [GO:0010544]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of protein secretion [GO:0050709]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of triglyceride metabolic process [GO:0090209]; neuron projection development [GO:0031175]; nitric oxide mediated signal transduction [GO:0007263]; NMDA glutamate receptor clustering [GO:0097114]; phospholipid efflux [GO:0033700]; positive regulation by host of viral process [GO:0044794]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endocytosis [GO:0045807]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heparan sulfate proteoglycan binding [GO:1905860]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of lipid transport across blood-brain barrier [GO:1903002]; positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neuron projection development [GO:0010976]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phospholipid efflux [GO:1902995]; protein import [GO:0017038]; receptor-mediated endocytosis [GO:0006898]; regulation of amyloid fibril formation [GO:1905906]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of amyloid-beta clearance [GO:1900221]; regulation of axon extension [GO:0030516]; regulation of behavioral fear response [GO:2000822]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of cellular response to very-low-density lipoprotein particle stimulus [GO:1905890]; regulation of cholesterol metabolic process [GO:0090181]; regulation of innate immune response [GO:0045088]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein metabolic process [GO:0051246]; regulation of protein-containing complex assembly [GO:0043254]; response to caloric restriction [GO:0061771]; response to dietary excess [GO:0002021]; response to reactive oxygen species [GO:0000302]; reverse cholesterol transport [GO:0043691]; synaptic transmission, cholinergic [GO:0007271]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; triglyceride-rich lipoprotein particle clearance [GO:0071830]; vasodilation [GO:0042311]; very-low-density lipoprotein particle clearance [GO:0034447]; very-low-density lipoprotein particle remodeling [GO:0034372]; virion assembly [GO:0019068]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2498325, ECO:0000269|PubMed:30333625}. Secreted, extracellular space {ECO:0000269|PubMed:8340399}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:9488694}. Extracellular vesicle {ECO:0000269|PubMed:26387950}. Endosome, multivesicular body {ECO:0000269|PubMed:26387950}. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins (PubMed:1911868, PubMed:8340399). Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans-dependent manner (PubMed:9488694). Lipidation induces the release from the extracellular matrix (PubMed:9488694). Colocalizes with CD63 and PMEL at exosomes and in intraluminal vesicles within multivesicular endosomes. {ECO:0000269|PubMed:1911868, ECO:0000269|PubMed:26387950, ECO:0000269|PubMed:8340399, ECO:0000269|PubMed:9488694}.
P02652	reviewed	APOA2_HUMAN	Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))]	APOA2	Homo sapiens (Human)	100	FUNCTION: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.		animal organ regeneration [GO:0031100]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; diacylglycerol catabolic process [GO:0046340]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; lipoprotein metabolic process [GO:0042157]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of cholesterol import [GO:0060621]; negative regulation of cholesterol transport [GO:0032375]; negative regulation of cholesterol transporter activity [GO:0060695]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of lipase activity [GO:0060192]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; peptidyl-methionine modification [GO:0018206]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid catabolic process [GO:0009395]; phospholipid efflux [GO:0033700]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of phagocytosis [GO:0050766]; protein oxidation [GO:0018158]; protein stabilization [GO:0050821]; regulation of intestinal cholesterol absorption [GO:0030300]; regulation of protein stability [GO:0031647]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to xenobiotic stimulus [GO:0009410]; reverse cholesterol transport [GO:0043691]; triglyceride metabolic process [GO:0006641]; triglyceride-rich lipoprotein particle remodeling [GO:0034370]	blood microparticle [GO:0072562]; chylomicron [GO:0042627]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361]	apolipoprotein receptor binding [GO:0034190]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor binding [GO:0070653]; lipase inhibitor activity [GO:0055102]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]	blood microparticle [GO:0072562]; chylomicron [GO:0042627]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361]; apolipoprotein receptor binding [GO:0034190]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor binding [GO:0070653]; lipase inhibitor activity [GO:0055102]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; animal organ regeneration [GO:0031100]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; diacylglycerol catabolic process [GO:0046340]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; lipoprotein metabolic process [GO:0042157]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of cholesterol import [GO:0060621]; negative regulation of cholesterol transport [GO:0032375]; negative regulation of cholesterol transporter activity [GO:0060695]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of lipase activity [GO:0060192]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; peptidyl-methionine modification [GO:0018206]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid catabolic process [GO:0009395]; phospholipid efflux [GO:0033700]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of phagocytosis [GO:0050766]; protein oxidation [GO:0018158]; protein stabilization [GO:0050821]; regulation of intestinal cholesterol absorption [GO:0030300]; regulation of protein stability [GO:0031647]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to xenobiotic stimulus [GO:0009410]; reverse cholesterol transport [GO:0043691]; triglyceride metabolic process [GO:0006641]; triglyceride-rich lipoprotein particle remodeling [GO:0034370]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24116940}.
P02654	reviewed	APOC1_HUMAN	Apolipoprotein C-I (Apo-CI) (ApoC-I) (Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I]	APOC1	Homo sapiens (Human)	83	FUNCTION: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. {ECO:0000269|PubMed:17339654, ECO:0000303|PubMed:25160599}.	MISCELLANEOUS: Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon. {ECO:0000303|PubMed:25160599}.	cholesterol efflux [GO:0033344]; cholesterol metabolic process [GO:0008203]; chylomicron remnant clearance [GO:0034382]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; lipoprotein metabolic process [GO:0042157]; negative regulation of cholesterol transport [GO:0032375]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of lipoprotein lipase activity [GO:0051005]; negative regulation of phosphatidylcholine catabolic process [GO:0010900]; negative regulation of receptor-mediated endocytosis [GO:0048261]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; phospholipid efflux [GO:0033700]; plasma lipoprotein particle remodeling [GO:0034369]; regulation of cholesterol transport [GO:0032374]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle assembly [GO:0034379]; very-low-density lipoprotein particle clearance [GO:0034447]	chylomicron [GO:0042627]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; very-low-density lipoprotein particle [GO:0034361]	fatty acid binding [GO:0005504]; lipase inhibitor activity [GO:0055102]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipase inhibitor activity [GO:0004859]	chylomicron [GO:0042627]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; very-low-density lipoprotein particle [GO:0034361]; fatty acid binding [GO:0005504]; lipase inhibitor activity [GO:0055102]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipase inhibitor activity [GO:0004859]; cholesterol efflux [GO:0033344]; cholesterol metabolic process [GO:0008203]; chylomicron remnant clearance [GO:0034382]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; lipoprotein metabolic process [GO:0042157]; negative regulation of cholesterol transport [GO:0032375]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of lipoprotein lipase activity [GO:0051005]; negative regulation of phosphatidylcholine catabolic process [GO:0010900]; negative regulation of receptor-mediated endocytosis [GO:0048261]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; phospholipid efflux [GO:0033700]; plasma lipoprotein particle remodeling [GO:0034369]; regulation of cholesterol transport [GO:0032374]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle assembly [GO:0034379]; very-low-density lipoprotein particle clearance [GO:0034447]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:2835369}.
P02655	reviewed	APOC2_HUMAN	Apolipoprotein C-II (Apo-CII) (ApoC-II) (Apolipoprotein C2) [Cleaved into: Proapolipoprotein C-II (ProapoC-II)]	APOC2 APC2	Homo sapiens (Human)	101	FUNCTION: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. {ECO:0000269|PubMed:2209608, ECO:0000303|PubMed:22304839}.		cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; chylomicron remnant clearance [GO:0034382]; chylomicron remodeling [GO:0034371]; high-density lipoprotein particle clearance [GO:0034384]; lipid catabolic process [GO:0016042]; negative regulation of cholesterol transport [GO:0032375]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of receptor-mediated endocytosis [GO:0048261]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; phospholipid efflux [GO:0033700]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of phospholipid catabolic process [GO:0060697]; positive regulation of triglyceride catabolic process [GO:0010898]; positive regulation of very-low-density lipoprotein particle remodeling [GO:0010902]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; triglyceride-rich lipoprotein particle remodeling [GO:0034370]; very-low-density lipoprotein particle remodeling [GO:0034372]	chylomicron [GO:0042627]; early endosome [GO:0005769]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intermediate-density lipoprotein particle [GO:0034363]; low-density lipoprotein particle [GO:0034362]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361]	lipase inhibitor activity [GO:0055102]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; molecular function activator activity [GO:0140677]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]	chylomicron [GO:0042627]; early endosome [GO:0005769]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intermediate-density lipoprotein particle [GO:0034363]; low-density lipoprotein particle [GO:0034362]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361]; lipase inhibitor activity [GO:0055102]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; molecular function activator activity [GO:0140677]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; chylomicron remnant clearance [GO:0034382]; chylomicron remodeling [GO:0034371]; high-density lipoprotein particle clearance [GO:0034384]; lipid catabolic process [GO:0016042]; negative regulation of cholesterol transport [GO:0032375]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of receptor-mediated endocytosis [GO:0048261]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; phospholipid efflux [GO:0033700]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of phospholipid catabolic process [GO:0060697]; positive regulation of triglyceride catabolic process [GO:0010898]; positive regulation of very-low-density lipoprotein particle remodeling [GO:0010902]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; triglyceride-rich lipoprotein particle remodeling [GO:0034370]; very-low-density lipoprotein particle remodeling [GO:0034372]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3525527}.
P02656	reviewed	APOC3_HUMAN	Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3)	APOC3	Homo sapiens (Human)	99	FUNCTION: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013). {ECO:0000269|PubMed:18408013, ECO:0000303|PubMed:18201179, ECO:0000303|PubMed:22510806}.		cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; chylomicron remnant clearance [GO:0034382]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle remodeling [GO:0034375]; lipoprotein metabolic process [GO:0042157]; negative regulation of cholesterol import [GO:0060621]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of high-density lipoprotein particle clearance [GO:0010987]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of lipoprotein lipase activity [GO:0051005]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of receptor-mediated endocytosis [GO:0048261]; negative regulation of triglyceride catabolic process [GO:0010897]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; phospholipid efflux [GO:0033700]; regulation of Cdc42 protein signal transduction [GO:0032489]; reverse cholesterol transport [GO:0043691]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle assembly [GO:0034379]	chylomicron [GO:0042627]; collagen-containing extracellular matrix [GO:0062023]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intermediate-density lipoprotein particle [GO:0034363]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361]	cholesterol binding [GO:0015485]; enzyme regulator activity [GO:0030234]; high-density lipoprotein particle receptor binding [GO:0070653]; lipase inhibitor activity [GO:0055102]; phospholipid binding [GO:0005543]	chylomicron [GO:0042627]; collagen-containing extracellular matrix [GO:0062023]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intermediate-density lipoprotein particle [GO:0034363]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361]; cholesterol binding [GO:0015485]; enzyme regulator activity [GO:0030234]; high-density lipoprotein particle receptor binding [GO:0070653]; lipase inhibitor activity [GO:0055102]; phospholipid binding [GO:0005543]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; chylomicron remnant clearance [GO:0034382]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle remodeling [GO:0034375]; lipoprotein metabolic process [GO:0042157]; negative regulation of cholesterol import [GO:0060621]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of high-density lipoprotein particle clearance [GO:0010987]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of lipoprotein lipase activity [GO:0051005]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of receptor-mediated endocytosis [GO:0048261]; negative regulation of triglyceride catabolic process [GO:0010897]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; phospholipid efflux [GO:0033700]; regulation of Cdc42 protein signal transduction [GO:0032489]; reverse cholesterol transport [GO:0043691]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle assembly [GO:0034379]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:18201179, ECO:0000303|PubMed:22510806}.
P02671	reviewed	FIBA_HUMAN	Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]	FGA	Homo sapiens (Human)	866	FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.		adaptive immune response [GO:0002250]; blood coagulation, common pathway [GO:0072377]; blood coagulation, fibrin clot formation [GO:0072378]; cell-matrix adhesion [GO:0007160]; fibrinolysis [GO:0042730]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; plasminogen activation [GO:0031639]; platelet aggregation [GO:0070527]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein secretion [GO:0050714]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vasoconstriction [GO:0045907]; protein polymerization [GO:0051258]; protein-containing complex assembly [GO:0065003]; response to calcium ion [GO:0051592]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]	extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; adaptive immune response [GO:0002250]; blood coagulation, common pathway [GO:0072377]; blood coagulation, fibrin clot formation [GO:0072378]; cell-matrix adhesion [GO:0007160]; fibrinolysis [GO:0042730]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; plasminogen activation [GO:0031639]; platelet aggregation [GO:0070527]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein secretion [GO:0050714]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vasoconstriction [GO:0045907]; protein polymerization [GO:0051258]; protein-containing complex assembly [GO:0065003]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9628725}.
P02675	reviewed	FIBB_HUMAN	Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]	FGB	Homo sapiens (Human)	491	FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.		adaptive immune response [GO:0002250]; blood coagulation, fibrin clot formation [GO:0072378]; cell-matrix adhesion [GO:0007160]; cellular response to interleukin-1 [GO:0071347]; cellular response to leptin stimulus [GO:0044320]; fibrinolysis [GO:0042730]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; plasminogen activation [GO:0031639]; platelet aggregation [GO:0070527]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein secretion [GO:0050714]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vasoconstriction [GO:0045907]; protein polymerization [GO:0051258]; protein-containing complex assembly [GO:0065003]; response to calcium ion [GO:0051592]	blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; synapse [GO:0045202]	extracellular matrix structural constituent [GO:0005201]; protein-folding chaperone binding [GO:0051087]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]	blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; synapse [GO:0045202]; extracellular matrix structural constituent [GO:0005201]; protein-folding chaperone binding [GO:0051087]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; adaptive immune response [GO:0002250]; blood coagulation, fibrin clot formation [GO:0072378]; cell-matrix adhesion [GO:0007160]; cellular response to interleukin-1 [GO:0071347]; cellular response to leptin stimulus [GO:0044320]; fibrinolysis [GO:0042730]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; plasminogen activation [GO:0031639]; platelet aggregation [GO:0070527]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein secretion [GO:0050714]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vasoconstriction [GO:0045907]; protein polymerization [GO:0051258]; protein-containing complex assembly [GO:0065003]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10074346, ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9628725}.
P02679	reviewed	FIBG_HUMAN	Fibrinogen gamma chain	FGG PRO2061	Homo sapiens (Human)	453	FUNCTION: Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.	MISCELLANEOUS: The gamma-chain carries the main binding site for the platelet receptor.; MISCELLANEOUS: [Isoform Gamma-B]: Present in about 10% of the fibrinogen molecules in plasma but absent from those in the platelets.	blood coagulation, fibrin clot formation [GO:0072378]; cell-matrix adhesion [GO:0007160]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; fibrinolysis [GO:0042730]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; plasminogen activation [GO:0031639]; platelet aggregation [GO:0070527]; platelet maturation [GO:0036345]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein secretion [GO:0050714]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vasoconstriction [GO:0045907]; protein polymerization [GO:0051258]; protein secretion [GO:0009306]; protein-containing complex assembly [GO:0065003]; response to calcium ion [GO:0051592]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]	cell adhesion molecule binding [GO:0050839]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; cell adhesion molecule binding [GO:0050839]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; blood coagulation, fibrin clot formation [GO:0072378]; cell-matrix adhesion [GO:0007160]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; fibrinolysis [GO:0042730]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; plasminogen activation [GO:0031639]; platelet aggregation [GO:0070527]; platelet maturation [GO:0036345]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein secretion [GO:0050714]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vasoconstriction [GO:0045907]; protein polymerization [GO:0051258]; protein secretion [GO:0009306]; protein-containing complex assembly [GO:0065003]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10074346, ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9628725}.
P02686	reviewed	MBP_HUMAN	Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein)	MBP	Homo sapiens (Human)	304	FUNCTION: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}.	MISCELLANEOUS: [Isoform 3]: Contains a non-traditional PY nuclear localization signal. Mutagenesis of Cys-81 to Ser prevents dimerization. {ECO:0000305}.	axon ensheathment [GO:0008366]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; immune response [GO:0006955]; maintenance of blood-brain barrier [GO:0035633]; MAPK cascade [GO:0000165]; membrane organization [GO:0061024]; myelination [GO:0042552]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of metalloendopeptidase activity [GO:1904685]; response to toxic substance [GO:0009636]; sensory perception of sound [GO:0007605]; substantia nigra development [GO:0021762]	cell periphery [GO:0071944]; cell surface [GO:0009986]; compact myelin [GO:0043218]; cytosol [GO:0005829]; internode region of axon [GO:0033269]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]	calmodulin binding [GO:0005516]; lipid binding [GO:0008289]; protease binding [GO:0002020]; structural constituent of myelin sheath [GO:0019911]	cell periphery [GO:0071944]; cell surface [GO:0009986]; compact myelin [GO:0043218]; cytosol [GO:0005829]; internode region of axon [GO:0033269]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; calmodulin binding [GO:0005516]; lipid binding [GO:0008289]; protease binding [GO:0002020]; structural constituent of myelin sheath [GO:0019911]; axon ensheathment [GO:0008366]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; immune response [GO:0006955]; maintenance of blood-brain barrier [GO:0035633]; MAPK cascade [GO:0000165]; membrane organization [GO:0061024]; myelination [GO:0042552]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of metalloendopeptidase activity [GO:1904685]; response to toxic substance [GO:0009636]; sensory perception of sound [GO:0007605]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:22609403}. Note=Targeted to nucleus in oligodendrocytes.
P02689	reviewed	MYP2_HUMAN	Myelin P2 protein (Peripheral myelin protein 2)	PMP2	Homo sapiens (Human)	132	FUNCTION: May play a role in lipid transport protein in Schwann cells. May bind cholesterol. {ECO:0000269|PubMed:20421974}.	MISCELLANEOUS: P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.	fatty acid transport [GO:0015908]; membrane organization [GO:0061024]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209]; nucleus [GO:0005634]	cholesterol binding [GO:0015485]; fatty acid binding [GO:0005504]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209]; nucleus [GO:0005634]; cholesterol binding [GO:0015485]; fatty acid binding [GO:0005504]; fatty acid transport [GO:0015908]; membrane organization [GO:0061024]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
P02708	reviewed	ACHA_HUMAN	Acetylcholine receptor subunit alpha	CHRNA1 ACHRA CHNRA	Homo sapiens (Human)	457	FUNCTION: [Isoform 1]: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. {ECO:0000269|PubMed:27375219}.; FUNCTION: [Isoform 2]: Non functional acetylcholine receptor alpha subunit which is not integrated into functional acetylcholine-gated cation-selective channels. {ECO:0000269|PubMed:8788941}.	MISCELLANEOUS: [Isoform 2]: Acetylcholine receptors incorporating that alpha subunit do not bind alpha-bungarotoxin. {ECO:0000269|PubMed:8788941}.	muscle cell cellular homeostasis [GO:0046716]; musculoskeletal movement [GO:0050881]; neuromuscular junction development [GO:0007528]; neuromuscular process [GO:0050905]; neuromuscular synaptic transmission [GO:0007274]; neuron cellular homeostasis [GO:0070050]; neuronal action potential [GO:0019228]; regulation of membrane potential [GO:0042391]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; skeletal muscle contraction [GO:0003009]; skeletal muscle tissue growth [GO:0048630]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated channel complex [GO:0005892]; cell surface [GO:0009986]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; monoatomic ion channel activity [GO:0005216]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	acetylcholine-gated channel complex [GO:0005892]; cell surface [GO:0009986]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; monoatomic ion channel activity [GO:0005216]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; muscle cell cellular homeostasis [GO:0046716]; musculoskeletal movement [GO:0050881]; neuromuscular junction development [GO:0007528]; neuromuscular process [GO:0050905]; neuromuscular synaptic transmission [GO:0007274]; neuron cellular homeostasis [GO:0070050]; neuronal action potential [GO:0019228]; regulation of membrane potential [GO:0042391]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; skeletal muscle contraction [GO:0003009]; skeletal muscle tissue growth [GO:0048630]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:27375219}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:27375219}; Multi-pass membrane protein {ECO:0000255}.
P02724	reviewed	GLPA_HUMAN	Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a)	GYPA GPA	Homo sapiens (Human)	150	FUNCTION: Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV). {ECO:0000269|PubMed:10926825, ECO:0000269|PubMed:12813056, ECO:0000269|PubMed:14604989, ECO:0000269|PubMed:15331714, ECO:0000269|PubMed:19438409, ECO:0000269|PubMed:35835865, ECO:0000269|PubMed:8009226}.	MISCELLANEOUS: Involved in several unequal homologous recombinations or gene conversion events, predominantly with GYPB and more rarely with GYPE. The resulting fusion proteins are observed in different phenotypes and encode low incidence bloodgroup antigens.		ankyrin-1 complex [GO:0170014]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; virus receptor activity [GO:0001618]	ankyrin-1 complex [GO:0170014]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; virus receptor activity [GO:0001618]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11402026}; Single-pass type I membrane protein {ECO:0000269|PubMed:11402026}. Note=Appears to be colocalized with SLC4A1.
P02730	reviewed	B3AT_HUMAN	Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233)	SLC4A1 AE1 DI EPB3	Homo sapiens (Human)	911	FUNCTION: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:35835865, PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307, PubMed:1538405, PubMed:20151848). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:35835865, PubMed:1538405, PubMed:20151848). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes. {ECO:0000269|PubMed:14630931}.		bicarbonate transport [GO:0015701]; blood coagulation [GO:0007596]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; erythrocyte development [GO:0048821]; intracellular monoatomic ion homeostasis [GO:0006873]; monoatomic anion transport [GO:0006820]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; negative regulation of urine volume [GO:0035811]; pH elevation [GO:0045852]; plasma membrane phospholipid scrambling [GO:0017121]; protein localization to plasma membrane [GO:0072659]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085]	ankyrin-1 complex [GO:0170014]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cortical cytoskeleton [GO:0030863]; cytoplasmic side of plasma membrane [GO:0009898]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; Z disc [GO:0030018]	ankyrin binding [GO:0030506]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; hemoglobin binding [GO:0030492]; monoatomic anion transmembrane transporter activity [GO:0008509]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; solute:inorganic anion antiporter activity [GO:0005452]	ankyrin-1 complex [GO:0170014]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cortical cytoskeleton [GO:0030863]; cytoplasmic side of plasma membrane [GO:0009898]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; Z disc [GO:0030018]; ankyrin binding [GO:0030506]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; hemoglobin binding [GO:0030492]; monoatomic anion transmembrane transporter activity [GO:0008509]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; solute:inorganic anion antiporter activity [GO:0005452]; bicarbonate transport [GO:0015701]; blood coagulation [GO:0007596]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; erythrocyte development [GO:0048821]; intracellular monoatomic ion homeostasis [GO:0006873]; monoatomic anion transport [GO:0006820]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; negative regulation of urine volume [GO:0035811]; pH elevation [GO:0045852]; plasma membrane phospholipid scrambling [GO:0017121]; protein localization to plasma membrane [GO:0072659]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:26542571, ECO:0000269|PubMed:7506871}; Multi-pass membrane protein {ECO:0000269|PubMed:26542571}. Basolateral cell membrane {ECO:0000269|PubMed:7506871}; Multi-pass membrane protein {ECO:0000269|PubMed:7506871}. Note=Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney. {ECO:0000269|PubMed:7506871}.
P02741	reviewed	CRP_HUMAN	C-reactive protein [Cleaved into: C-reactive protein(1-205)]	CRP PTX1	Homo sapiens (Human)	224	FUNCTION: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.	MISCELLANEOUS: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.	acute-phase response [GO:0006953]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of mononuclear cell proliferation [GO:0032945]; opsonization [GO:0008228]; positive regulation of gene expression [GO:0010628]; positive regulation of superoxide anion generation [GO:0032930]; regulation of interleukin-8 production [GO:0032677]; vasoconstriction [GO:0042310]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; choline binding [GO:0033265]; complement component C1q complex binding [GO:0001849]; identical protein binding [GO:0042802]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor binding [GO:0050750]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; choline binding [GO:0033265]; complement component C1q complex binding [GO:0001849]; identical protein binding [GO:0042802]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor binding [GO:0050750]; acute-phase response [GO:0006953]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of mononuclear cell proliferation [GO:0032945]; opsonization [GO:0008228]; positive regulation of gene expression [GO:0010628]; positive regulation of superoxide anion generation [GO:0032930]; regulation of interleukin-8 production [GO:0032677]; vasoconstriction [GO:0042310]	SUBCELLULAR LOCATION: Secreted.
P02743	reviewed	SAMP_HUMAN	Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]	APCS PTX2	Homo sapiens (Human)	223	FUNCTION: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.		acute-phase response [GO:0006953]; chaperone-mediated protein complex assembly [GO:0051131]; innate immune response [GO:0045087]; negative regulation by host of viral exo-alpha-sialidase activity [GO:0044869]; negative regulation by host of viral glycoprotein metabolic process [GO:0044871]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of exo-alpha-sialidase activity [GO:1903016]; negative regulation of glycoprotein metabolic process [GO:1903019]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral process [GO:0048525]; negative regulation of wound healing [GO:0061045]; protein folding [GO:0006457]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; complement component C1q complex binding [GO:0001849]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082]; virion binding [GO:0046790]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; complement component C1q complex binding [GO:0001849]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082]; virion binding [GO:0046790]; acute-phase response [GO:0006953]; chaperone-mediated protein complex assembly [GO:0051131]; innate immune response [GO:0045087]; negative regulation by host of viral exo-alpha-sialidase activity [GO:0044869]; negative regulation by host of viral glycoprotein metabolic process [GO:0044871]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of exo-alpha-sialidase activity [GO:1903016]; negative regulation of glycoprotein metabolic process [GO:1903019]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral process [GO:0048525]; negative regulation of wound healing [GO:0061045]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Secreted.
P02745	reviewed	C1QA_HUMAN	Complement C1q subcomponent subunit A	C1QA	Homo sapiens (Human)	245	FUNCTION: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.		astrocyte activation [GO:0048143]; cell-cell signaling [GO:0007267]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; complement-mediated synapse pruning [GO:0150062]; innate immune response [GO:0045087]; microglial cell activation [GO:0001774]; neuron remodeling [GO:0016322]; synapse organization [GO:0050808]; synapse pruning [GO:0098883]; vertebrate eye-specific patterning [GO:0150064]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; complement component C1 complex [GO:0005602]; complement component C1q complex [GO:0062167]; extracellular region [GO:0005576]; postsynapse [GO:0098794]; synapse [GO:0045202]	amyloid-beta binding [GO:0001540]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; complement component C1 complex [GO:0005602]; complement component C1q complex [GO:0062167]; extracellular region [GO:0005576]; postsynapse [GO:0098794]; synapse [GO:0045202]; amyloid-beta binding [GO:0001540]; astrocyte activation [GO:0048143]; cell-cell signaling [GO:0007267]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; complement-mediated synapse pruning [GO:0150062]; innate immune response [GO:0045087]; microglial cell activation [GO:0001774]; neuron remodeling [GO:0016322]; synapse organization [GO:0050808]; synapse pruning [GO:0098883]; vertebrate eye-specific patterning [GO:0150064]	SUBCELLULAR LOCATION: Secreted.
P02746	reviewed	C1QB_HUMAN	Complement C1q subcomponent subunit B	C1QB	Homo sapiens (Human)	253	FUNCTION: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.		complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; synapse pruning [GO:0098883]	blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; complement component C1 complex [GO:0005602]; complement component C1q complex [GO:0062167]; extracellular region [GO:0005576]; postsynapse [GO:0098794]; synapse [GO:0045202]		blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; complement component C1 complex [GO:0005602]; complement component C1q complex [GO:0062167]; extracellular region [GO:0005576]; postsynapse [GO:0098794]; synapse [GO:0045202]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; synapse pruning [GO:0098883]	SUBCELLULAR LOCATION: Secreted.
P02747	reviewed	C1QC_HUMAN	Complement C1q subcomponent subunit C	C1QC C1QG	Homo sapiens (Human)	245	FUNCTION: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.		complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of macrophage differentiation [GO:0045650]; synapse pruning [GO:0098883]	blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; complement component C1 complex [GO:0005602]; complement component C1q complex [GO:0062167]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; postsynapse [GO:0098794]; synapse [GO:0045202]		blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; complement component C1 complex [GO:0005602]; complement component C1q complex [GO:0062167]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; postsynapse [GO:0098794]; synapse [GO:0045202]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of macrophage differentiation [GO:0045650]; synapse pruning [GO:0098883]	SUBCELLULAR LOCATION: Secreted.
P02748	reviewed	CO9_HUMAN	Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]	C9	Homo sapiens (Human)	559	FUNCTION: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:9634479, PubMed:9212048, PubMed:26841934). C9 is the pore-forming subunit of the MAC (PubMed:4055801, PubMed:26841934, PubMed:30111885). {ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:30111885, ECO:0000269|PubMed:4055801, ECO:0000269|PubMed:9212048, ECO:0000269|PubMed:9634479}.		cell killing [GO:0001906]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]; protein homooligomerization [GO:0051260]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; other organism cell membrane [GO:0044218]; plasma membrane [GO:0005886]		blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; other organism cell membrane [GO:0044218]; plasma membrane [GO:0005886]; cell killing [GO:0001906]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22832194, ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:8603752, ECO:0000269|PubMed:9212048, ECO:0000269|PubMed:9634479}. Target cell membrane {ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:30111885, ECO:0000269|PubMed:9212048}; Multi-pass membrane protein {ECO:0000269|PubMed:26841934}. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore. {ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:30111885, ECO:0000269|PubMed:4055801, ECO:0000269|PubMed:9634479}.
P02749	reviewed	APOH_HUMAN	Beta-2-glycoprotein 1 (APC inhibitor) (Activated protein C-binding protein) (Anticardiolipin cofactor) (Apolipoprotein H) (Apo-H) (Beta-2-glycoprotein I) (B2GPI) (Beta(2)GPI)	APOH B2G1	Homo sapiens (Human)	345	FUNCTION: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.		blood coagulation, intrinsic pathway [GO:0007597]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood coagulation [GO:0030195]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; plasminogen activation [GO:0031639]; positive regulation of blood coagulation [GO:0030194]; positive regulation of lipoprotein lipase activity [GO:0051006]; regulation of fibrinolysis [GO:0051917]; triglyceride metabolic process [GO:0006641]; triglyceride transport [GO:0034197]	cell surface [GO:0009986]; chylomicron [GO:0042627]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; platelet dense granule lumen [GO:0031089]; very-low-density lipoprotein particle [GO:0034361]	heparin binding [GO:0008201]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; phospholipid binding [GO:0005543]	cell surface [GO:0009986]; chylomicron [GO:0042627]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; platelet dense granule lumen [GO:0031089]; very-low-density lipoprotein particle [GO:0034361]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; phospholipid binding [GO:0005543]; blood coagulation, intrinsic pathway [GO:0007597]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood coagulation [GO:0030195]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; plasminogen activation [GO:0031639]; positive regulation of blood coagulation [GO:0030194]; positive regulation of lipoprotein lipase activity [GO:0051006]; regulation of fibrinolysis [GO:0051917]; triglyceride metabolic process [GO:0006641]; triglyceride transport [GO:0034197]	SUBCELLULAR LOCATION: Secreted.
P02750	reviewed	A2GL_HUMAN	Leucine-rich alpha-2-glycoprotein (LRG)	LRG1 LRG	Homo sapiens (Human)	347			brown fat cell differentiation [GO:0050873]; keratinocyte migration [GO:0051546]; leukocyte adhesion to vascular endothelial cell [GO:0061756]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; response to bacterium [GO:0009617]; wound healing, spreading of epidermal cells [GO:0035313]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; brown fat cell differentiation [GO:0050873]; keratinocyte migration [GO:0051546]; leukocyte adhesion to vascular endothelial cell [GO:0061756]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; response to bacterium [GO:0009617]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: Secreted.
P02751	reviewed	FINC_HUMAN	Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]	FN1 FN	Homo sapiens (Human)	2477	FUNCTION: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617). {ECO:0000250|UniProtKB:P11276, ECO:0000269|PubMed:3024962, ECO:0000269|PubMed:34089617, ECO:0000269|PubMed:3593230, ECO:0000269|PubMed:3900070, ECO:0000269|PubMed:7989369}.; FUNCTION: [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. {ECO:0000269|PubMed:11209058, ECO:0000269|PubMed:15665290, ECO:0000269|PubMed:19379667, ECO:0000269|PubMed:8114919}.; FUNCTION: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. {ECO:0000250|UniProtKB:P11276}.	MISCELLANEOUS: [Isoform 16]: Expressed by fetal and tumor-associated cells. {ECO:0000305}.	acute-phase response [GO:0006953]; angiogenesis [GO:0001525]; biological process involved in interaction with symbiont [GO:0051702]; calcium-independent cell-matrix adhesion [GO:0007161]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell-substrate junction assembly [GO:0007044]; endodermal cell differentiation [GO:0035987]; heart development [GO:0007507]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of monocyte activation [GO:0150102]; negative regulation of transforming growth factor beta production [GO:0071635]; nervous system development [GO:0007399]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; peptide cross-linking [GO:0018149]; positive regulation of axon extension [GO:0045773]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; regulation of cell shape [GO:0008360]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein phosphorylation [GO:0001932]; response to wounding [GO:0009611]; substrate adhesion-dependent cell spreading [GO:0034446]; wound healing [GO:0042060]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]	collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activator activity [GO:0016504]; protease binding [GO:0002020]; proteoglycan binding [GO:0043394]; signaling receptor binding [GO:0005102]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activator activity [GO:0016504]; protease binding [GO:0002020]; proteoglycan binding [GO:0043394]; signaling receptor binding [GO:0005102]; acute-phase response [GO:0006953]; angiogenesis [GO:0001525]; biological process involved in interaction with symbiont [GO:0051702]; calcium-independent cell-matrix adhesion [GO:0007161]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell-substrate junction assembly [GO:0007044]; endodermal cell differentiation [GO:0035987]; heart development [GO:0007507]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of monocyte activation [GO:0150102]; negative regulation of transforming growth factor beta production [GO:0071635]; nervous system development [GO:0007399]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; peptide cross-linking [GO:0018149]; positive regulation of axon extension [GO:0045773]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; regulation of cell shape [GO:0008360]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein phosphorylation [GO:0001932]; response to wounding [GO:0009611]; substrate adhesion-dependent cell spreading [GO:0034446]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:29100092}. Secreted {ECO:0000250|UniProtKB:P11276}.
P02753	reviewed	RET4_HUMAN	Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)]	RBP4 PRO2222	Homo sapiens (Human)	201	FUNCTION: Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496). {ECO:0000269|PubMed:22665496, ECO:0000305, ECO:0000305|PubMed:5541771}.		cardiac muscle tissue development [GO:0048738]; embryonic organ morphogenesis [GO:0048562]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; embryonic skeletal system development [GO:0048706]; eye development [GO:0001654]; female genitalia morphogenesis [GO:0048807]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; lung development [GO:0030324]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of insulin secretion [GO:0032024]; response to retinoic acid [GO:0032526]; retinol metabolic process [GO:0042572]; retinol transport [GO:0034633]; urinary bladder development [GO:0060157]; uterus development [GO:0060065]; vagina development [GO:0060068]; visual perception [GO:0007601]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	retinal binding [GO:0016918]; retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; retinal binding [GO:0016918]; retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632]; cardiac muscle tissue development [GO:0048738]; embryonic organ morphogenesis [GO:0048562]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; embryonic skeletal system development [GO:0048706]; eye development [GO:0001654]; female genitalia morphogenesis [GO:0048807]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; lung development [GO:0030324]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of insulin secretion [GO:0032024]; response to retinoic acid [GO:0032526]; retinol metabolic process [GO:0042572]; retinol transport [GO:0034633]; urinary bladder development [GO:0060157]; uterus development [GO:0060065]; vagina development [GO:0060068]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12237133, ECO:0000269|PubMed:2444024, ECO:0000269|PubMed:5541771}.
P02760	reviewed	AMBP_HUMAN	Protein AMBP (Protein HC) [Cleaved into: Alpha-1-microglobulin (EC 1.6.2.-) (Alpha-1 microglycoprotein) (Complex-forming glycoprotein heterogeneous in charge); Inter-alpha-trypsin inhibitor light chain (ITI-LC) (Bikunin) (EDC1) (HI-30) (Uronic-acid-rich protein); Trypstatin]	AMBP HCP ITIL	Homo sapiens (Human)	352	FUNCTION: [Alpha-1-microglobulin]: Antioxidant and tissue repair protein with reductase, heme-binding and radical-scavenging activities. Removes and protects against harmful oxidants and repairs macromolecules in intravascular and extravascular spaces and in intracellular compartments (PubMed:11877257, PubMed:15683711, PubMed:22096585, PubMed:23157686, PubMed:23642167, PubMed:25698971, PubMed:32823731, PubMed:32092412). Intravascularly, plays a regulatory role in red cell homeostasis by preventing heme- and reactive oxygen species-induced cell damage. Binds and degrades free heme to protect fetal and adult red blood cells from hemolysis (PubMed:11877257, PubMed:32092412). Reduces extracellular methemoglobin, a Fe3+ (ferric) form of hemoglobin that cannot bind oxygen, back to the Fe2+ (ferrous) form deoxyhemoglobin, which has oxygen-carrying potential (PubMed:15683711). Upon acute inflammation, inhibits oxidation of low-density lipoprotein particles by MPO and limits vascular damage (PubMed:25698971). Extravascularly, protects from oxidation products formed on extracellular matrix structures and cell membranes. Catalyzes the reduction of carbonyl groups on oxidized collagen fibers and preserves cellular and extracellular matrix ultrastructures (PubMed:23642167, PubMed:22096585). Importantly, counteracts the oxidative damage at blood-placenta interface, preventing leakage of free fetal hemoglobin into the maternal circulation (PubMed:21356557). Intracellularly, has a role in maintaining mitochondrial redox homeostasis. Bound to complex I of the respiratory chain of mitochondria, may scavenge free radicals and preserve mitochondrial ATP synthesis. Protects renal tubule epithelial cells from heme-induced oxidative damage to mitochondria (PubMed:23157686, PubMed:32823731). Reduces cytochrome c from Fe3+ (ferric) to the Fe2+ (ferrous) state through formation of superoxide anion radicals in the presence of ascorbate or NADH/NADPH electron donor cofactors, ascorbate being the preferred cofactor (PubMed:15683711). Has a chaperone role in facilitating the correct folding of bikunin in the endoplasmic reticulum compartment (By similarity). {ECO:0000250|UniProtKB:Q07456, ECO:0000269|PubMed:11877257, ECO:0000269|PubMed:15683711, ECO:0000269|PubMed:21356557, ECO:0000269|PubMed:22096585, ECO:0000269|PubMed:23157686, ECO:0000269|PubMed:23642167, ECO:0000269|PubMed:25698971, ECO:0000269|PubMed:32092412, ECO:0000269|PubMed:32823731}.; FUNCTION: [Inter-alpha-trypsin inhibitor light chain]: Kunitz-type serine protease inhibitor and structural component of extracellular matrix with a role in extracellular space remodeling and cell adhesion (PubMed:25301953, PubMed:20463016). Among others, has antiprotease activity toward kallikrein, a protease involved in airway inflammation; inhibits GZMK/granzyme, a granule-stored serine protease involved in NK and T cell cytotoxic responses; and inhibits PLG/plasmin, a protease required for activation of matrix metalloproteinases (PubMed:16873769, PubMed:10480954, PubMed:15917224). As part of I-alpha-I complex, provides for the heavy chains to be transferred from I-alpha-I complex to hyaluronan in the presence of TNFAIP6, in a dynamic process that releases free bikunin and remodels extracellular matrix proteoglycan structures. Free bikunin, but not its heavy chain-bound form, acts as potent protease inhibitor in airway secretions (PubMed:16873769). Part of hyaluronan-rich extracellular matrix that surrounds oocyte during cumulus oophorus expansion, an indispensable process for proper ovulation (By similarity). Also inhibits calcium oxalate crystallization (PubMed:7676539). {ECO:0000250|UniProtKB:Q07456, ECO:0000269|PubMed:10480954, ECO:0000269|PubMed:15917224, ECO:0000269|PubMed:16873769, ECO:0000269|PubMed:20463016, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:7676539}.; FUNCTION: [Trypstatin]: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases. {ECO:0000250|UniProtKB:Q64240}.	MISCELLANEOUS: In vitro, the first twelve residues of the amino end of the inhibitor appear to have a reactive site capable of inhibiting the activity of a number of enzymes. Its in vivo function is not known.	cell adhesion [GO:0007155]; female pregnancy [GO:0007565]; heme catabolic process [GO:0042167]; negative regulation of immune response [GO:0050777]; negative regulation of JNK cascade [GO:0046329]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	calcium channel inhibitor activity [GO:0019855]; calcium oxalate binding [GO:0046904]; carbohydrate binding [GO:0030246]; heme binding [GO:0020037]; IgA binding [GO:0019862]; oxidoreductase activity [GO:0016491]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase inhibitor activity [GO:0004867]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; calcium channel inhibitor activity [GO:0019855]; calcium oxalate binding [GO:0046904]; carbohydrate binding [GO:0030246]; heme binding [GO:0020037]; IgA binding [GO:0019862]; oxidoreductase activity [GO:0016491]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase inhibitor activity [GO:0004867]; cell adhesion [GO:0007155]; female pregnancy [GO:0007565]; heme catabolic process [GO:0042167]; negative regulation of immune response [GO:0050777]; negative regulation of JNK cascade [GO:0046329]	SUBCELLULAR LOCATION: [Alpha-1-microglobulin]: Secreted {ECO:0000269|PubMed:11877257, ECO:0000269|PubMed:32092412}. Endoplasmic reticulum {ECO:0000269|PubMed:22096585}. Cytoplasm, cytosol {ECO:0000269|PubMed:32092412}. Cell membrane {ECO:0000269|PubMed:22096585, ECO:0000269|PubMed:32092412}; Peripheral membrane protein {ECO:0000305|PubMed:22096585, ECO:0000305|PubMed:32092412}. Nucleus membrane {ECO:0000269|PubMed:22096585}; Peripheral membrane protein {ECO:0000305|PubMed:22096585}. Mitochondrion inner membrane {ECO:0000305|PubMed:23157686}; Peripheral membrane protein {ECO:0000305|PubMed:23157686}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:22096585}. Note=The cellular uptake occurs via a non-endocytotic pathway and allows for localization to various membrane structures. A specific binding to plasma membrane suggests the presence of a cell receptor, yet to be identified. Directly binds collagen fibers type I. {ECO:0000269|PubMed:22096585}.; SUBCELLULAR LOCATION: [Inter-alpha-trypsin inhibitor light chain]: Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313}.
P02763	reviewed	A1AG1_HUMAN	Alpha-1-acid glycoprotein 1 (AGP 1) (Orosomucoid-1) (OMD 1)	ORM1 AGP1	Homo sapiens (Human)	201	FUNCTION: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. {ECO:0000269|PubMed:17008009, ECO:0000269|PubMed:17321687}.		acute-phase response [GO:0006953]; inflammatory response [GO:0006954]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of immune system process [GO:0002682]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]		blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; acute-phase response [GO:0006953]; inflammatory response [GO:0006954]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Secreted.
P02765	reviewed	FETUA_HUMAN	Alpha-2-HS-glycoprotein (Alpha-2-Z-globulin) (Ba-alpha-2-glycoprotein) (Fetuin-A) [Cleaved into: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B]	AHSG FETUA PRO2743	Homo sapiens (Human)	367	FUNCTION: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.		acute-phase response [GO:0006953]; negative regulation of bone mineralization [GO:0030502]; negative regulation of insulin receptor signaling pathway [GO:0046627]; ossification [GO:0001503]; pinocytosis [GO:0006907]; positive regulation of phagocytosis [GO:0050766]; regulation of bone mineralization [GO:0030500]; regulation of inflammatory response [GO:0050727]; skeletal system development [GO:0001501]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; kinase inhibitor activity [GO:0019210]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; kinase inhibitor activity [GO:0019210]; acute-phase response [GO:0006953]; negative regulation of bone mineralization [GO:0030502]; negative regulation of insulin receptor signaling pathway [GO:0046627]; ossification [GO:0001503]; pinocytosis [GO:0006907]; positive regulation of phagocytosis [GO:0050766]; regulation of bone mineralization [GO:0030500]; regulation of inflammatory response [GO:0050727]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted.
P02766	reviewed	TTHY_HUMAN	Transthyretin (ATTR) (Prealbumin) (TBPA)	TTR PALB	Homo sapiens (Human)	147	FUNCTION: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. {ECO:0000269|PubMed:3714052}.	MISCELLANEOUS: Tetramer dissociation and partial unfolding leads to the formation of aggregates and amyloid fibrils. Small molecules that occupy at least one of the thyroid hormone binding sites stabilize the tetramer, and thereby stabilize the native state and protect against misfolding and the formation of amyloid fibrils.; MISCELLANEOUS: Two binding sites for thyroxine are located in the channel. Less than 1% of plasma prealbumin molecules are normally involved in thyroxine transport. L-thyroxine binds to the transthyretin by an order of magnitude stronger than does the triiodo-L-thyronine. Thyroxine-binding globulin is the major carrier protein for thyroid hormones in man.; MISCELLANEOUS: About 40% of plasma transthyretin circulates in a tight protein-protein complex with the plasma retinol-binding protein (RBP). The formation of the complex with RBP stabilizes the binding of retinol to RBP and decreases the glomerular filtration and renal catabolism of the relatively small RBP molecule. There is evidence for 2 binding sites for RBP, one possibly being a region that includes Ile-104, located on the outer surface of the transthyretin molecule.	purine nucleobase metabolic process [GO:0006144]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	hormone activity [GO:0005179]; identical protein binding [GO:0042802]; thyroid hormone binding [GO:0070324]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; thyroid hormone binding [GO:0070324]; purine nucleobase metabolic process [GO:0006144]	SUBCELLULAR LOCATION: Secreted. Cytoplasm.
P02768	reviewed	ALBU_HUMAN	Albumin	ALB GIG20 GIG42 PRO0903 PRO1708 PRO2044 PRO2619 PRO2675 UNQ696/PRO1341	Homo sapiens (Human)	609	FUNCTION: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017). {ECO:0000250|UniProtKB:P02769, ECO:0000269|PubMed:19021548, ECO:0000269|PubMed:6234017, ECO:0000305|PubMed:1630489}.		cellular response to starvation [GO:0009267]; maintenance of mitochondrion location [GO:0051659]; negative regulation of apoptotic process [GO:0043066]; negative regulation of programmed cell death [GO:0043069]; retina homeostasis [GO:0001895]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; protein-containing complex [GO:0032991]	antioxidant activity [GO:0016209]; copper ion binding [GO:0005507]; DNA binding [GO:0003677]; enterobactin binding [GO:1903981]; exogenous protein binding [GO:0140272]; fatty acid binding [GO:0005504]; identical protein binding [GO:0042802]; protein-folding chaperone binding [GO:0051087]; pyridoxal phosphate binding [GO:0030170]; toxic substance binding [GO:0015643]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; protein-containing complex [GO:0032991]; antioxidant activity [GO:0016209]; copper ion binding [GO:0005507]; DNA binding [GO:0003677]; enterobactin binding [GO:1903981]; exogenous protein binding [GO:0140272]; fatty acid binding [GO:0005504]; identical protein binding [GO:0042802]; protein-folding chaperone binding [GO:0051087]; pyridoxal phosphate binding [GO:0030170]; toxic substance binding [GO:0015643]; cellular response to starvation [GO:0009267]; maintenance of mitochondrion location [GO:0051659]; negative regulation of apoptotic process [GO:0043066]; negative regulation of programmed cell death [GO:0043069]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Secreted.
P02771	reviewed	FETA_HUMAN	Alpha-fetoprotein (Alpha-1-fetoprotein) (Alpha-fetoglobulin)	AFP HPAFP	Homo sapiens (Human)	609	FUNCTION: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.		ovulation from ovarian follicle [GO:0001542]; progesterone metabolic process [GO:0042448]; SMAD protein signal transduction [GO:0060395]	cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; metal ion binding [GO:0046872]; ovulation from ovarian follicle [GO:0001542]; progesterone metabolic process [GO:0042448]; SMAD protein signal transduction [GO:0060395]	SUBCELLULAR LOCATION: Secreted.
P02774	reviewed	VTDB_HUMAN	Vitamin D-binding protein (DBP) (VDB) (Gc protein-derived macrophage activating factor) (Gc-MAF) (GcMAF) (Gc-globulin) (Group-specific component) (Gc) (Vitamin D-binding protein-macrophage activating factor) (DBP-maf)	GC	Homo sapiens (Human)	474	FUNCTION: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. {ECO:0000305|PubMed:16302727}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	vitamin D metabolic process [GO:0042359]; vitamin transport [GO:0051180]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]	actin binding [GO:0003779]; calcidiol binding [GO:1902118]; vitamin D binding [GO:0005499]; vitamin transmembrane transporter activity [GO:0090482]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; actin binding [GO:0003779]; calcidiol binding [GO:1902118]; vitamin D binding [GO:0005499]; vitamin transmembrane transporter activity [GO:0090482]; vitamin D metabolic process [GO:0042359]; vitamin transport [GO:0051180]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2423133}.
P02775	reviewed	CXCL7_HUMAN	Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))]	PPBP CTAP3 CXCL7 SCYB7 TGB1 THBGB1	Homo sapiens (Human)	128	FUNCTION: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; defense response to bacterium [GO:0042742]; glucose transmembrane transport [GO:1904659]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell division [GO:0051781]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; tertiary granule lumen [GO:1904724]	chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; glucose transmembrane transporter activity [GO:0005355]; growth factor activity [GO:0008083]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; tertiary granule lumen [GO:1904724]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; glucose transmembrane transporter activity [GO:0005355]; growth factor activity [GO:0008083]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; defense response to bacterium [GO:0042742]; glucose transmembrane transport [GO:1904659]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell division [GO:0051781]	SUBCELLULAR LOCATION: Secreted.
P02776	reviewed	PLF4_HUMAN	Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form (Endothelial cell growth inhibitor)]	PF4 CXCL4 SCYB4	Homo sapiens (Human)	101	FUNCTION: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. {ECO:0000269|PubMed:7644496}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; cytokine-mediated signaling pathway [GO:0019221]; defense response to protozoan [GO:0042832]; inflammatory response [GO:0006954]; killing by host of symbiont cells [GO:0051873]; leukocyte chemotaxis [GO:0030595]; negative regulation of angiogenesis [GO:0016525]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of MHC class II biosynthetic process [GO:0045347]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell population proliferation [GO:0042127]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]	chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; heparin binding [GO:0008201]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; heparin binding [GO:0008201]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; cytokine-mediated signaling pathway [GO:0019221]; defense response to protozoan [GO:0042832]; inflammatory response [GO:0006954]; killing by host of symbiont cells [GO:0051873]; leukocyte chemotaxis [GO:0030595]; negative regulation of angiogenesis [GO:0016525]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of MHC class II biosynthetic process [GO:0045347]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7644496}.
P02778	reviewed	CXL10_HUMAN	C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73)]	CXCL10 INP10 SCYB10	Homo sapiens (Human)	98	FUNCTION: Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity). {ECO:0000250|UniProtKB:P17515, ECO:0000269|PubMed:11157474, ECO:0000269|PubMed:12663757, ECO:0000269|PubMed:12750173, ECO:0000269|PubMed:19151743, ECO:0000269|PubMed:22652417, ECO:0000269|PubMed:7540647}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; antiviral innate immune response [GO:0140374]; blood circulation [GO:0008015]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to heat [GO:0034605]; cellular response to interleukin-17 [GO:0097398]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; endothelial cell activation [GO:0042118]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; muscle organ development [GO:0007517]; negative regulation of angiogenesis [GO:0016525]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myoblast fusion [GO:1901740]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of T cell migration [GO:2000406]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of endothelial tube morphogenesis [GO:1901509]; regulation of T cell chemotaxis [GO:0010819]; response to auditory stimulus [GO:0010996]; response to gamma radiation [GO:0010332]; response to vitamin D [GO:0033280]; signal transduction [GO:0007165]; T cell chemotaxis [GO:0010818]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cAMP-dependent protein kinase regulator activity [GO:0008603]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cAMP-dependent protein kinase regulator activity [GO:0008603]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; antiviral innate immune response [GO:0140374]; blood circulation [GO:0008015]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to heat [GO:0034605]; cellular response to interleukin-17 [GO:0097398]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; endothelial cell activation [GO:0042118]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; muscle organ development [GO:0007517]; negative regulation of angiogenesis [GO:0016525]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myoblast fusion [GO:1901740]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of T cell migration [GO:2000406]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of endothelial tube morphogenesis [GO:1901509]; regulation of T cell chemotaxis [GO:0010819]; response to auditory stimulus [GO:0010996]; response to gamma radiation [GO:0010332]; response to vitamin D [GO:0033280]; signal transduction [GO:0007165]; T cell chemotaxis [GO:0010818]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21183794}.
P02786	reviewed	TFR1_HUMAN	Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]	TFRC	Homo sapiens (Human)	760	FUNCTION: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). {ECO:0000250, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:3568132}.; FUNCTION: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.	MISCELLANEOUS: Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.; MISCELLANEOUS: Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.	acute-phase response [GO:0006953]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to xenobiotic stimulus [GO:0071466]; intracellular iron ion homeostasis [GO:0006879]; intracellular signal transduction [GO:0035556]; iron ion transport [GO:0006826]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial fusion [GO:0010637]; osteoclast differentiation [GO:0030316]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of gene expression [GO:0010628]; positive regulation of isotype switching [GO:0045830]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of T cell proliferation [GO:0042102]; receptor internalization [GO:0031623]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to manganese ion [GO:0010042]; response to nutrient [GO:0007584]; response to retinoic acid [GO:0032526]; transferrin transport [GO:0033572]; transport across blood-brain barrier [GO:0150104]	basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; HFE-transferrin receptor complex [GO:1990712]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]	double-stranded RNA binding [GO:0003725]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; transferrin receptor activity [GO:0004998]; virus receptor activity [GO:0001618]	basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; HFE-transferrin receptor complex [GO:1990712]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; double-stranded RNA binding [GO:0003725]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; transferrin receptor activity [GO:0004998]; virus receptor activity [GO:0001618]; acute-phase response [GO:0006953]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to xenobiotic stimulus [GO:0071466]; intracellular iron ion homeostasis [GO:0006879]; intracellular signal transduction [GO:0035556]; iron ion transport [GO:0006826]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial fusion [GO:0010637]; osteoclast differentiation [GO:0030316]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of gene expression [GO:0010628]; positive regulation of isotype switching [GO:0045830]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of T cell proliferation [GO:0042102]; receptor internalization [GO:0031623]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to manganese ion [GO:0010042]; response to nutrient [GO:0007584]; response to retinoic acid [GO:0032526]; transferrin transport [GO:0033572]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.; SUBCELLULAR LOCATION: [Transferrin receptor protein 1, serum form]: Secreted {ECO:0000269|PubMed:17081065}.
P02787	reviewed	TRFE_HUMAN	Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)	TF PRO1400	Homo sapiens (Human)	698	FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.; FUNCTION: (Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use. {ECO:0000269|PubMed:22327295, ECO:0000269|PubMed:22343719}.; FUNCTION: (Microbial infection) Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use. {ECO:0000269|PubMed:31636418}.		actin filament organization [GO:0007015]; antibacterial humoral response [GO:0019731]; cellular response to iron ion [GO:0071281]; ERK1 and ERK2 cascade [GO:0070371]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]; osteoclast differentiation [GO:0030316]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell motility [GO:2000147]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of phosphorylation [GO:0042327]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of iron ion transport [GO:0034756]; regulation of protein stability [GO:0031647]; retina homeostasis [GO:0001895]; SMAD protein signal transduction [GO:0060395]	apical plasma membrane [GO:0016324]; basal part of cell [GO:0045178]; basal plasma membrane [GO:0009925]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum lumen [GO:0005788]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982]	ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; iron chaperone activity [GO:0034986]; transferrin receptor binding [GO:1990459]	apical plasma membrane [GO:0016324]; basal part of cell [GO:0045178]; basal plasma membrane [GO:0009925]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum lumen [GO:0005788]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; iron chaperone activity [GO:0034986]; transferrin receptor binding [GO:1990459]; actin filament organization [GO:0007015]; antibacterial humoral response [GO:0019731]; cellular response to iron ion [GO:0071281]; ERK1 and ERK2 cascade [GO:0070371]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]; osteoclast differentiation [GO:0030316]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell motility [GO:2000147]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of phosphorylation [GO:0042327]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of iron ion transport [GO:0034756]; regulation of protein stability [GO:0031647]; retina homeostasis [GO:0001895]; SMAD protein signal transduction [GO:0060395]	SUBCELLULAR LOCATION: Secreted.
P02788	reviewed	TRFL_HUMAN	Lactotransferrin (Lactoferrin) (EC 3.4.21.-) (Growth-inhibiting protein 12) (Talalactoferrin) [Cleaved into: Lactoferricin-H (Lfcin-H); Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C]	LTF GIG12 LF	Homo sapiens (Human)	710	FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. {ECO:0000269|PubMed:22900286}.; FUNCTION: [Lactotransferrin]: Major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions (PubMed:14573629, PubMed:1599934, PubMed:6802759, PubMed:3169987, PubMed:11179314, PubMed:12693969). Has antimicrobial activity, which depends on the extracellular cation concentration (PubMed:6802759). Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane (PubMed:14573629, PubMed:1599934, PubMed:6802759, PubMed:3169987, PubMed:11179314, PubMed:12693969). Can also prevent bacterial biofilm development in P.aeruginosa infection (PubMed:12037568). Has weak antifungal activity against C.albicans (PubMed:11083624). Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth (PubMed:15166119). Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection (PubMed:17079302). Can inhibit papillomavirus infections (PubMed:17481742). Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling (PubMed:20345905). Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells (PubMed:19033648). Stimulates VEGFA-mediated endothelial cell migration and proliferation (PubMed:16842782). Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs) (PubMed:9359845). Also binds specifically to pneumococcal surface protein A (PspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA (PubMed:9359845). {ECO:0000269|PubMed:11083624, ECO:0000269|PubMed:11179314, ECO:0000269|PubMed:12037568, ECO:0000269|PubMed:12693969, ECO:0000269|PubMed:14573629, ECO:0000269|PubMed:15166119, ECO:0000269|PubMed:1599934, ECO:0000269|PubMed:16842782, ECO:0000269|PubMed:17079302, ECO:0000269|PubMed:17481742, ECO:0000269|PubMed:19033648, ECO:0000269|PubMed:20345905, ECO:0000269|PubMed:3169987, ECO:0000269|PubMed:6802759, ECO:0000269|PubMed:9359845}.; FUNCTION: Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection (PubMed:17481742). N-terminal region shows strong antifungal activity against C.albicans (PubMed:11083624). Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site. {ECO:0000269|PubMed:11083624, ECO:0000269|PubMed:17481742}.; FUNCTION: [Kaliocin-1]: Has antimicrobial activity and is able to permeabilize different ions through liposomal membranes. {ECO:0000269|PubMed:12693969}.; FUNCTION: [Lactoferroxin-A]: Has opioid antagonist activity (PubMed:1369293). Shows preference for mu-receptor (PubMed:1369293). {ECO:0000269|PubMed:1369293}.; FUNCTION: [Lactoferroxin-B]: Has opioid antagonist activity (PubMed:1369293). Shows higher degrees of preference for kappa-receptors than for mu-receptors (PubMed:1369293). {ECO:0000269|PubMed:1369293}.; FUNCTION: [Lactoferroxin-C]: Has opioid antagonist activity (PubMed:1369293). Shows higher degrees of preference for kappa-receptors than for mu-receptors (PubMed:1369293). {ECO:0000269|PubMed:1369293}.; FUNCTION: The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions (PubMed:12535064). This function contributes to the antimicrobial activity (PubMed:12535064). Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites (PubMed:12535064). {ECO:0000269|PubMed:12535064}.; FUNCTION: [Isoform DeltaLf]: Transcription factor with antiproliferative properties and ability to induce cell cycle arrest (PubMed:15222485). Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELENOH promoters (PubMed:22320386). {ECO:0000269|PubMed:15222485, ECO:0000269|PubMed:22320386}.	MISCELLANEOUS: [Isoform DeltaLf]: Contains a phosphoserine at position 10 (alternate). Contains a O-linked (GlcNAc) serine at position 10 (alternate). O-GlcNAcylation at Ser-10 inhibits DNA binding and negatively regulates DeltaLf transcriptional activity, whereas phosphorylation activates it. Phosphorylation at Ser-10 also promotes proteasomal degradation. {ECO:0000305}.	antibacterial humoral response [GO:0019731]; antifungal humoral response [GO:0019732]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; bone morphogenesis [GO:0060349]; defense response to Gram-negative bacterium [GO:0050829]; humoral immune response [GO:0006959]; innate immune response in mucosa [GO:0002227]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]; killing of cells of another organism [GO:0031640]; negative regulation by host of viral process [GO:0044793]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of osteoclast development [GO:2001205]; negative regulation of single-species biofilm formation in or on host organism [GO:1900229]; negative regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000308]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral process [GO:0048525]; ossification [GO:0001503]; positive regulation of bone mineralization involved in bone maturation [GO:1900159]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; proteolysis [GO:0006508]; regulation of cytokine production [GO:0001817]; regulation of tumor necrosis factor production [GO:0032680]; retina homeostasis [GO:0001895]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; phagocytic vesicle lumen [GO:0097013]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; secretory granule [GO:0030141]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; DNA binding [GO:0003677]; heparin binding [GO:0008201]; iron ion binding [GO:0005506]; lipopolysaccharide binding [GO:0001530]; membrane destabilizing activity [GO:0140912]; protein serine/threonine kinase activator activity [GO:0043539]; serine-type endopeptidase activity [GO:0004252]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; phagocytic vesicle lumen [GO:0097013]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; secretory granule [GO:0030141]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; DNA binding [GO:0003677]; heparin binding [GO:0008201]; iron ion binding [GO:0005506]; lipopolysaccharide binding [GO:0001530]; membrane destabilizing activity [GO:0140912]; protein serine/threonine kinase activator activity [GO:0043539]; serine-type endopeptidase activity [GO:0004252]; antibacterial humoral response [GO:0019731]; antifungal humoral response [GO:0019732]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; bone morphogenesis [GO:0060349]; defense response to Gram-negative bacterium [GO:0050829]; humoral immune response [GO:0006959]; innate immune response in mucosa [GO:0002227]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]; killing of cells of another organism [GO:0031640]; negative regulation by host of viral process [GO:0044793]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of osteoclast development [GO:2001205]; negative regulation of single-species biofilm formation in or on host organism [GO:1900229]; negative regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000308]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral process [GO:0048525]; ossification [GO:0001503]; positive regulation of bone mineralization involved in bone maturation [GO:1900159]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; proteolysis [GO:0006508]; regulation of cytokine production [GO:0001817]; regulation of tumor necrosis factor production [GO:0032680]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted. Cytoplasmic granule. Note=Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils.; SUBCELLULAR LOCATION: [Isoform DeltaLf]: Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm.
P02790	reviewed	HEMO_HUMAN	Hemopexin (Beta-1B-glycoprotein)	HPX	Homo sapiens (Human)	462	FUNCTION: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	MISCELLANEOUS: The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity). {ECO:0000250}.	heme metabolic process [GO:0042168]; heme transport [GO:0015886]; hemoglobin metabolic process [GO:0020027]; intracellular iron ion homeostasis [GO:0006879]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; type II interferon-mediated signaling pathway [GO:0060333]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	heme transmembrane transporter activity [GO:0015232]; metal ion binding [GO:0046872]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; heme transmembrane transporter activity [GO:0015232]; metal ion binding [GO:0046872]; heme metabolic process [GO:0042168]; heme transport [GO:0015886]; hemoglobin metabolic process [GO:0020027]; intracellular iron ion homeostasis [GO:0006879]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; type II interferon-mediated signaling pathway [GO:0060333]	SUBCELLULAR LOCATION: Secreted.
P02792	reviewed	FRIL_HUMAN	Ferritin light chain (Ferritin L subunit)	FTL	Homo sapiens (Human)	175	FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). {ECO:0000250, ECO:0000269|PubMed:19923220, ECO:0000269|PubMed:20159981}.		intracellular iron ion homeostasis [GO:0006879]; intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826]	autolysosome [GO:0044754]; azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular ferritin complex [GO:0008043]; membrane [GO:0016020]	ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]	autolysosome [GO:0044754]; azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular ferritin complex [GO:0008043]; membrane [GO:0016020]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; intracellular iron ion homeostasis [GO:0006879]; intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826]	
P02794	reviewed	FRIH_HUMAN	Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed]	FTH1 FTH FTHL6 OK/SW-cl.84 PIG15	Homo sapiens (Human)	183	FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). {ECO:0000250|UniProtKB:P09528, ECO:0000269|PubMed:9003196}.		immune response [GO:0006955]; intracellular iron ion homeostasis [GO:0006879]; intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]	autolysosome [GO:0044754]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intracellular ferritin complex [GO:0008043]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]	ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; iron ion sequestering activity [GO:0140315]	autolysosome [GO:0044754]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intracellular ferritin complex [GO:0008043]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; iron ion sequestering activity [GO:0140315]; immune response [GO:0006955]; intracellular iron ion homeostasis [GO:0006879]; intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P19130}.
P02795	reviewed	MT2_HUMAN	Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II)	MT2A CES1 MT2	Homo sapiens (Human)	61	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	MISCELLANEOUS: This metallothionein binds zinc.	cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to erythropoietin [GO:0036018]; cellular response to interleukin-3 [GO:0036016]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular copper ion homeostasis [GO:0006878]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to erythropoietin [GO:0036018]; cellular response to interleukin-3 [GO:0036016]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular copper ion homeostasis [GO:0006878]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	
P02808	reviewed	STAT_HUMAN	Statherin	STATH	Homo sapiens (Human)	62	FUNCTION: Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.		biomineral tissue development [GO:0031214]; defense response to bacterium [GO:0042742]; negative regulation of bone mineralization [GO:0030502]; ossification [GO:0001503]; saliva secretion [GO:0046541]	extracellular region [GO:0005576]	extracellular matrix constituent, lubricant activity [GO:0030197]; hydroxyapatite binding [GO:0046848]; structural constituent of tooth enamel [GO:0030345]	extracellular region [GO:0005576]; extracellular matrix constituent, lubricant activity [GO:0030197]; hydroxyapatite binding [GO:0046848]; structural constituent of tooth enamel [GO:0030345]; biomineral tissue development [GO:0031214]; defense response to bacterium [GO:0042742]; negative regulation of bone mineralization [GO:0030502]; ossification [GO:0001503]; saliva secretion [GO:0046541]	SUBCELLULAR LOCATION: Secreted.
P02810	reviewed	PRPC_HUMAN	Salivary acidic proline-rich phosphoprotein 1/2 (Db-s) (PRP-1/PRP-2) (Parotid acidic protein) (Pa) (Parotid double-band protein) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) [Cleaved into: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (Db-F) (PIF-F) (PRP-3/PRP-4) (Protein A); Peptide P-C]	PRH1; PRH2	Homo sapiens (Human)	166	FUNCTION: PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.			extracellular space [GO:0005615]		extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted.
P02812	reviewed	PRB2_HUMAN	Basic salivary proline-rich protein 2 (Salivary proline-rich protein) (Con1 glycoprotein) [Cleaved into: Basic proline-rich peptide IB-1; Basic proline-rich peptide P-E (IB-9); Basic proline-rich peptide IB-7; Basic proline-rich peptide IB-8c (Basic peptide P-F); Basic proline-rich peptide IB-4]	PRB2	Homo sapiens (Human)	416		MISCELLANEOUS: Peptides IB-9 and P-E are the same peptide.		extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
P02814	reviewed	SMR3B_HUMAN	Submaxillary gland androgen-regulated protein 3B (Proline-rich peptide P-B) (Proline-rich protein 3) [Cleaved into: Peptide P-A; Peptide D1A]	SMR3B PBII PRL3 PROL3	Homo sapiens (Human)	79			regulation of sensory perception of pain [GO:0051930]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	endopeptidase inhibitor activity [GO:0004866]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; endopeptidase inhibitor activity [GO:0004866]; regulation of sensory perception of pain [GO:0051930]	SUBCELLULAR LOCATION: Secreted.
P02818	reviewed	OSTCN_HUMAN	Osteocalcin (Bone Gla protein) (BGP) (Gamma-carboxyglutamic acid-containing protein)	BGLAP	Homo sapiens (Human)	100	FUNCTION: Bone protein that constitutes 1-2% of the total bone protein, and which acts as a negative regulator of bone formation (PubMed:3019668, PubMed:6967872). Functions to limit bone formation without impairing bone resorption or mineralization (By similarity). It binds strongly to apatite and calcium (PubMed:6967872). {ECO:0000250|UniProtKB:P86546, ECO:0000269|PubMed:3019668, ECO:0000269|PubMed:6967872}.; FUNCTION: The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development. {ECO:0000250|UniProtKB:P86546}.		bone development [GO:0060348]; bone mineralization [GO:0030282]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; cellular response to vitamin D [GO:0071305]; cellular response to zinc ion starvation [GO:0034224]; cognition [GO:0050890]; dephosphorylation [GO:0016311]; glucose homeostasis [GO:0042593]; learning or memory [GO:0007611]; negative regulation of bone development [GO:1903011]; osteoblast development [GO:0002076]; osteoblast differentiation [GO:0001649]; positive regulation of neurotransmitter secretion [GO:0001956]; regulation of bone mineralization [GO:0030500]; regulation of bone resorption [GO:0045124]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of osteoclast differentiation [GO:0045670]; regulation of testosterone biosynthetic process [GO:2000224]; response to activity [GO:0014823]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to glucocorticoid [GO:0051384]; response to gravity [GO:0009629]; response to hydroxyisoflavone [GO:0033594]; response to macrophage colony-stimulating factor [GO:0036005]; response to mechanical stimulus [GO:0009612]; response to testosterone [GO:0033574]; response to vitamin D [GO:0033280]; response to vitamin K [GO:0032571]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; skeletal system development [GO:0001501]; stem cell differentiation [GO:0048863]; type B pancreatic cell proliferation [GO:0044342]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; perikaryon [GO:0043204]; vesicle [GO:0031982]	calcium ion binding [GO:0005509]; hormone activity [GO:0005179]; hydroxyapatite binding [GO:0046848]; structural constituent of bone [GO:0008147]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; perikaryon [GO:0043204]; vesicle [GO:0031982]; calcium ion binding [GO:0005509]; hormone activity [GO:0005179]; hydroxyapatite binding [GO:0046848]; structural constituent of bone [GO:0008147]; structural molecule activity [GO:0005198]; bone development [GO:0060348]; bone mineralization [GO:0030282]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; cellular response to vitamin D [GO:0071305]; cellular response to zinc ion starvation [GO:0034224]; cognition [GO:0050890]; dephosphorylation [GO:0016311]; glucose homeostasis [GO:0042593]; learning or memory [GO:0007611]; negative regulation of bone development [GO:1903011]; osteoblast development [GO:0002076]; osteoblast differentiation [GO:0001649]; positive regulation of neurotransmitter secretion [GO:0001956]; regulation of bone mineralization [GO:0030500]; regulation of bone resorption [GO:0045124]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of osteoclast differentiation [GO:0045670]; regulation of testosterone biosynthetic process [GO:2000224]; response to activity [GO:0014823]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to glucocorticoid [GO:0051384]; response to gravity [GO:0009629]; response to hydroxyisoflavone [GO:0033594]; response to macrophage colony-stimulating factor [GO:0036005]; response to mechanical stimulus [GO:0009612]; response to testosterone [GO:0033574]; response to vitamin D [GO:0033280]; response to vitamin K [GO:0032571]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; skeletal system development [GO:0001501]; stem cell differentiation [GO:0048863]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6967872}.
P03372	reviewed	ESR1_HUMAN	Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)	ESR1 ESR NR3A1	Homo sapiens (Human)	595	FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). {ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}.	MISCELLANEOUS: Selective estrogen receptor modulators (SERMs), such as tamoxifen, raloxifene, toremifene, lasofoxifene, clomifene, femarelle and ormeloxifene, have tissue selective agonistic and antagonistic effects on the estrogen receptor (ER). They interfere with the ER association with coactivators or corepressors, mainly involving the AF-2 domain.; MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 3. {ECO:0000305}.	androgen metabolic process [GO:0008209]; antral ovarian follicle growth [GO:0001547]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; chromatin remodeling [GO:0006338]; epithelial cell development [GO:0002064]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; fibroblast proliferation [GO:0048144]; intracellular estrogen receptor signaling pathway [GO:0030520]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; male gonad development [GO:0008584]; mammary gland alveolus development [GO:0060749]; mammary gland branching involved in pregnancy [GO:0060745]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of gene expression [GO:0010629]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; prostate epithelial cord elongation [GO:0060523]; protein localization to chromatin [GO:0071168]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell apoptotic process [GO:1904035]; regulation of inflammatory response [GO:0050727]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; RNA polymerase II preinitiation complex assembly [GO:0051123]; signal transduction [GO:0007165]; stem cell differentiation [GO:0048863]; steroid hormone mediated signaling pathway [GO:0043401]; uterus development [GO:0060065]; vagina development [GO:0060068]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]	14-3-3 protein binding [GO:0071889]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled estrogen receptor activity [GO:0038054]; identical protein binding [GO:0042802]; nitric-oxide synthase regulator activity [GO:0030235]; nuclear estrogen receptor activity [GO:0030284]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor activity [GO:0004879]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; TBP-class protein binding [GO:0017025]; TFIIB-class transcription factor binding [GO:0001093]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]; 14-3-3 protein binding [GO:0071889]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled estrogen receptor activity [GO:0038054]; identical protein binding [GO:0042802]; nitric-oxide synthase regulator activity [GO:0030235]; nuclear estrogen receptor activity [GO:0030284]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor activity [GO:0004879]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; TBP-class protein binding [GO:0017025]; TFIIB-class transcription factor binding [GO:0001093]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]; androgen metabolic process [GO:0008209]; antral ovarian follicle growth [GO:0001547]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; chromatin remodeling [GO:0006338]; epithelial cell development [GO:0002064]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; fibroblast proliferation [GO:0048144]; intracellular estrogen receptor signaling pathway [GO:0030520]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; male gonad development [GO:0008584]; mammary gland alveolus development [GO:0060749]; mammary gland branching involved in pregnancy [GO:0060745]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of gene expression [GO:0010629]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; prostate epithelial cord elongation [GO:0060523]; protein localization to chromatin [GO:0071168]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell apoptotic process [GO:1904035]; regulation of inflammatory response [GO:0050727]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; RNA polymerase II preinitiation complex assembly [GO:0051123]; signal transduction [GO:0007165]; stem cell differentiation [GO:0048863]; steroid hormone mediated signaling pathway [GO:0043401]; uterus development [GO:0060065]; vagina development [GO:0060068]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:12682286, ECO:0000269|PubMed:20074560}. Cytoplasm {ECO:0000269|PubMed:12682286, ECO:0000269|PubMed:24498420}. Cell membrane {ECO:0000269|PubMed:12682286}; Peripheral membrane protein {ECO:0000269|PubMed:12682286}; Cytoplasmic side {ECO:0000269|PubMed:12682286}. Note=A minor fraction is associated with the inner membrane.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Single-pass type I membrane protein. Note=Associated with the inner membrane via palmitoylation (Probable). At least a subset exists as a transmembrane protein with a N-terminal extracellular domain. {ECO:0000305}.; SUBCELLULAR LOCATION: Nucleus. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
P03886	reviewed	NU1M_HUMAN	NADH-ubiquinone oxidoreductase chain 1 (EC 7.1.1.2) (NADH dehydrogenase subunit 1)	MT-ND1 MTND1 NADH1 ND1	Homo sapiens (Human)	318	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:1959619). Essential for the catalytic activity and assembly of complex I (PubMed:26929434, PubMed:1959619). {ECO:0000269|PubMed:1959619, ECO:0000269|PubMed:26929434}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P03887}; Multi-pass membrane protein {ECO:0000255}.
P03891	reviewed	NU2M_HUMAN	NADH-ubiquinone oxidoreductase chain 2 (EC 7.1.1.2) (NADH dehydrogenase subunit 2)	MT-ND2 MTND2 NADH2 ND2	Homo sapiens (Human)	347	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:16996290). Essential for the catalytic activity and assembly of complex I (PubMed:16996290). {ECO:0000269|PubMed:16996290}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]	ionotropic glutamate receptor binding [GO:0035255]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; protein kinase binding [GO:0019901]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; ionotropic glutamate receptor binding [GO:0035255]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; protein kinase binding [GO:0019901]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P03892}; Multi-pass membrane protein {ECO:0000255}.
P03897	reviewed	NU3M_HUMAN	NADH-ubiquinone oxidoreductase chain 3 (EC 7.1.1.2) (NADH dehydrogenase subunit 3)	MT-ND3 MTND3 NADH3 ND3	Homo sapiens (Human)	115	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:25118196). Essential for the catalytic activity of complex I (PubMed:25118196). {ECO:0000269|PubMed:25118196}.		aerobic respiration [GO:0009060]; cellular response to glucocorticoid stimulus [GO:0071385]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to light intensity [GO:0009642]; response to oxidative stress [GO:0006979]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; cellular response to glucocorticoid stimulus [GO:0071385]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to light intensity [GO:0009642]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein {ECO:0000255}.
P03905	reviewed	NU4M_HUMAN	NADH-ubiquinone oxidoreductase chain 4 (EC 7.1.1.2) (NADH dehydrogenase subunit 4)	MT-ND4 MTND4 NADH4 ND4	Homo sapiens (Human)	459	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:8644732, PubMed:8344246, PubMed:15250827). Essential for the catalytic activity and assembly of complex I (PubMed:8644732, PubMed:8344246, PubMed:15250827). {ECO:0000269|PubMed:15250827, ECO:0000269|PubMed:8344246, ECO:0000269|PubMed:8644732}.		aerobic respiration [GO:0009060]; cerebellum development [GO:0021549]; electron transport coupled proton transport [GO:0015990]; in utero embryonic development [GO:0001701]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]; ubiquinone binding [GO:0048039]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; ubiquinone binding [GO:0048039]; aerobic respiration [GO:0009060]; cerebellum development [GO:0021549]; electron transport coupled proton transport [GO:0015990]; in utero embryonic development [GO:0001701]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P03910}; Multi-pass membrane protein {ECO:0000255}.
P03915	reviewed	NU5M_HUMAN	NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) (NADH dehydrogenase subunit 5)	MT-ND5 MTND5 NADH5 ND5	Homo sapiens (Human)	603	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:15250827). Essential for the catalytic activity and assembly of complex I (PubMed:15250827). {ECO:0000269|PubMed:15250827}.		aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to organonitrogen compound [GO:0010243]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]; NADH dehydrogenase activity [GO:0003954]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; NADH dehydrogenase activity [GO:0003954]; aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to organonitrogen compound [GO:0010243]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein {ECO:0000255}.
P03923	reviewed	NU6M_HUMAN	NADH-ubiquinone oxidoreductase chain 6 (EC 7.1.1.2) (NADH dehydrogenase subunit 6)	MT-ND6 MTND6 NADH6 ND6	Homo sapiens (Human)	174	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:8644732, PubMed:14595656). Essential for the catalytic activity and assembly of complex I (PubMed:8644732, PubMed:14595656). {ECO:0000269|PubMed:14595656, ECO:0000269|PubMed:8644732}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to cocaine [GO:0042220]; response to hydrogen peroxide [GO:0042542]; response to nicotine [GO:0035094]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to cocaine [GO:0042220]; response to hydrogen peroxide [GO:0042542]; response to nicotine [GO:0035094]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein {ECO:0000255}.
P03928	reviewed	ATP8_HUMAN	ATP synthase protein 8 (A6L) (F-ATPase subunit 8)	MT-ATP8 ATP8 ATPASE8 MTATP8	Homo sapiens (Human)	68	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity). {ECO:0000250}.		proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]	proton transmembrane transporter activity [GO:0015078]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; proton transmembrane transporter activity [GO:0015078]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane protein.
P03950	reviewed	ANGI_HUMAN	Angiogenin (EC 3.1.27.-) (Ribonuclease 5) (RNase 5)	ANG RNASE5	Homo sapiens (Human)	147	FUNCTION: Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (PubMed:1400510, PubMed:21855800). Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus (PubMed:8127865). Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA (PubMed:12051708). Angiogenin induces vascularization of normal and malignant tissues (PubMed:19354288). Angiogenic activity is regulated by interaction with RNH1 in vivo (PubMed:19354288). {ECO:0000269|PubMed:12051708, ECO:0000269|PubMed:1400510, ECO:0000269|PubMed:19354288, ECO:0000269|PubMed:21855800, ECO:0000269|PubMed:8127865}.		actin filament polymerization [GO:0030041]; activation of phospholipase A2 activity [GO:0032431]; activation of phospholipase C activity [GO:0007202]; activation of protein kinase B activity [GO:0032148]; angiogenesis [GO:0001525]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell communication [GO:0007154]; cell migration [GO:0016477]; defense response to Gram-positive bacterium [GO:0050830]; diacylglycerol biosynthetic process [GO:0006651]; homeostatic process [GO:0042592]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of translation [GO:0017148]; oocyte maturation [GO:0001556]; ovarian follicle development [GO:0001541]; placenta development [GO:0001890]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein secretion [GO:0050714]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; rRNA transcription [GO:0009303]; tRNA catabolic process [GO:0016078]	actin cytoskeleton [GO:0015629]; angiogenin-PRI complex [GO:0032311]; basement membrane [GO:0005604]; chromosome [GO:0005694]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleus [GO:0005634]	actin binding [GO:0003779]; copper ion binding [GO:0005507]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; heparin binding [GO:0008201]; peptide binding [GO:0042277]; protein homodimerization activity [GO:0042803]; RNA endonuclease activity [GO:0004521]; RNA nuclease activity [GO:0004540]; rRNA binding [GO:0019843]; signaling receptor binding [GO:0005102]	actin cytoskeleton [GO:0015629]; angiogenin-PRI complex [GO:0032311]; basement membrane [GO:0005604]; chromosome [GO:0005694]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleus [GO:0005634]; actin binding [GO:0003779]; copper ion binding [GO:0005507]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; heparin binding [GO:0008201]; peptide binding [GO:0042277]; protein homodimerization activity [GO:0042803]; RNA endonuclease activity [GO:0004521]; RNA nuclease activity [GO:0004540]; rRNA binding [GO:0019843]; signaling receptor binding [GO:0005102]; actin filament polymerization [GO:0030041]; activation of phospholipase A2 activity [GO:0032431]; activation of phospholipase C activity [GO:0007202]; activation of protein kinase B activity [GO:0032148]; angiogenesis [GO:0001525]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell communication [GO:0007154]; cell migration [GO:0016477]; defense response to Gram-positive bacterium [GO:0050830]; diacylglycerol biosynthetic process [GO:0006651]; homeostatic process [GO:0042592]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of translation [GO:0017148]; oocyte maturation [GO:0001556]; ovarian follicle development [GO:0001541]; placenta development [GO:0001890]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein secretion [GO:0050714]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; rRNA transcription [GO:0009303]; tRNA catabolic process [GO:0016078]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q3TMQ6}. Secreted {ECO:0000250|UniProtKB:P10152}. Nucleus {ECO:0000269|PubMed:12051708, ECO:0000269|PubMed:25372031, ECO:0000269|PubMed:8127865}. Nucleus, nucleolus {ECO:0000269|PubMed:7945327}. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (PubMed:12051708). {ECO:0000269|PubMed:12051708}.
P03951	reviewed	FA11_HUMAN	Coagulation factor XI (FXI) (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]	F11	Homo sapiens (Human)	625	FUNCTION: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.		blood coagulation [GO:0007596]; plasminogen activation [GO:0031639]; positive regulation of fibrinolysis [GO:0051919]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]	heparin binding [GO:0008201]; identical protein binding [GO:0042802]; serine-type aminopeptidase activity [GO:0070009]; serine-type endopeptidase activity [GO:0004252]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; serine-type aminopeptidase activity [GO:0070009]; serine-type endopeptidase activity [GO:0004252]; blood coagulation [GO:0007596]; plasminogen activation [GO:0031639]; positive regulation of fibrinolysis [GO:0051919]	SUBCELLULAR LOCATION: Secreted.
P03952	reviewed	KLKB1_HUMAN	Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]	KLKB1 KLK3	Homo sapiens (Human)	638	FUNCTION: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.		blood coagulation [GO:0007596]; Factor XII activation [GO:0002542]; fibrinolysis [GO:0042730]; plasminogen activation [GO:0031639]; positive regulation of fibrinolysis [GO:0051919]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; blood coagulation [GO:0007596]; Factor XII activation [GO:0002542]; fibrinolysis [GO:0042730]; plasminogen activation [GO:0031639]; positive regulation of fibrinolysis [GO:0051919]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Secreted.
P03956	reviewed	MMP1_HUMAN	Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]	MMP1 CLG	Homo sapiens (Human)	469	FUNCTION: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369). {ECO:0000269|PubMed:1645757, ECO:0000269|PubMed:16807369, ECO:0000269|PubMed:2153297, ECO:0000269|PubMed:2557822}.		cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of protein-containing complex assembly [GO:0031334]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of protein-containing complex assembly [GO:0031334]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:2167156}.
P03971	reviewed	MIS_HUMAN	Muellerian-inhibiting factor (Anti-Muellerian hormone) (AMH) (Muellerian-inhibiting substance) (MIS)	AMH MIF	Homo sapiens (Human)	560	FUNCTION: Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation (PubMed:3754790, PubMed:34155118, PubMed:8469238). Also plays a role in Leydig cell differentiation and function (By similarity). In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed:14742691). AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression (PubMed:20861221, PubMed:34155118). {ECO:0000250|UniProtKB:P27106, ECO:0000269|PubMed:14742691, ECO:0000269|PubMed:20861221, ECO:0000269|PubMed:34155118, ECO:0000269|PubMed:3754790, ECO:0000269|PubMed:8469238}.		anti-Mullerian hormone signaling pathway [GO:1990262]; cell-cell signaling [GO:0007267]; gonadal mesoderm development [GO:0007506]; Leydig cell differentiation [GO:0033327]; Mullerian duct regression [GO:0001880]; negative regulation of ovarian follicle development [GO:2000355]; ovarian follicle development [GO:0001541]; positive regulation of gene expression [GO:0010628]; positive regulation of SMAD protein signal transduction [GO:0060391]; preantral ovarian follicle growth [GO:0001546]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; sex determination [GO:0007530]; sex differentiation [GO:0007548]; urogenital system development [GO:0001655]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	growth factor activity [GO:0008083]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; type II transforming growth factor beta receptor binding [GO:0005114]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; type II transforming growth factor beta receptor binding [GO:0005114]; anti-Mullerian hormone signaling pathway [GO:1990262]; cell-cell signaling [GO:0007267]; gonadal mesoderm development [GO:0007506]; Leydig cell differentiation [GO:0033327]; Mullerian duct regression [GO:0001880]; negative regulation of ovarian follicle development [GO:2000355]; ovarian follicle development [GO:0001541]; positive regulation of gene expression [GO:0010628]; positive regulation of SMAD protein signal transduction [GO:0060391]; preantral ovarian follicle growth [GO:0001546]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; sex determination [GO:0007530]; sex differentiation [GO:0007548]; urogenital system development [GO:0001655]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2974034, ECO:0000269|PubMed:3754790}.
P03973	reviewed	SLPI_HUMAN	Antileukoproteinase (ALP) (BLPI) (HUSI-1) (Mucus proteinase inhibitor) (MPI) (Protease inhibitor WAP4) (Secretory leukocyte protease inhibitor) (Seminal proteinase inhibitor) (WAP four-disulfide core domain protein 4)	SLPI WAP4 WFDC4	Homo sapiens (Human)	132	FUNCTION: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879). {ECO:0000250|UniProtKB:P97430, ECO:0000269|PubMed:10702419, ECO:0000269|PubMed:2039600, ECO:0000269|PubMed:2110563, ECO:0000269|PubMed:24121345, ECO:0000269|PubMed:24352879, ECO:0000269|PubMed:3462719, ECO:0000269|PubMed:3533531, ECO:0000305}.	MISCELLANEOUS: The pathologies of several chronic and acute diseases of the respiratory tract involve an imbalance between the proteases of cells involved in inflammatory responses and the inhibitors of these proteases. The inflammation-mediated release of neutrophil elastase in the lungs of patients whose levels of active alpha-1-antiprotease are compromised by genetic background, cigarette smoking, air pollutants, or a combination of all three can result in severe lung damage and a decreased lifespan. The relatively small size of this protein, its lack of glycosylation and its stability make this protein a candidate for use as a therapeutic agent in diseases mediated by leukocyte elastase-antielastase imbalances. {ECO:0000305}.	antibacterial humoral response [GO:0019731]; immune response [GO:0006955]; innate immune response [GO:0045087]; modulation of process of another organism [GO:0035821]; negative regulation of protein binding [GO:0032091]; negative regulation of viral genome replication [GO:0045071]; response to lipopolysaccharide [GO:0032496]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; specific granule lumen [GO:0035580]	DNA binding [GO:0003677]; endopeptidase inhibitor activity [GO:0004866]; enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; serine-type endopeptidase inhibitor activity [GO:0004867]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; specific granule lumen [GO:0035580]; DNA binding [GO:0003677]; endopeptidase inhibitor activity [GO:0004866]; enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; serine-type endopeptidase inhibitor activity [GO:0004867]; antibacterial humoral response [GO:0019731]; immune response [GO:0006955]; innate immune response [GO:0045087]; modulation of process of another organism [GO:0035821]; negative regulation of protein binding [GO:0032091]; negative regulation of viral genome replication [GO:0045071]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2039600, ECO:0000269|PubMed:24352879, ECO:0000269|PubMed:3462719, ECO:0000269|PubMed:3485543}.
P03999	reviewed	OPSB_HUMAN	Short-wave-sensitive opsin 1 (Blue cone photoreceptor pigment) (Blue-sensitive opsin) (BOP)	OPN1SW BCP	Homo sapiens (Human)	345	FUNCTION: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (Probable). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (By similarity). Involved in ensuring correct abundance and localization of retinal membrane proteins (By similarity). May increase spectral sensitivity in dim light (By similarity). {ECO:0000250|UniProtKB:P51491, ECO:0000305|PubMed:2937147}.		cellular response to light stimulus [GO:0071482]; cellular response to UV-A [GO:0071492]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; signal transduction [GO:0007165]; visual perception [GO:0007601]	cone photoreceptor outer segment [GO:0120199]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]	G protein-coupled photoreceptor activity [GO:0008020]; signaling receptor activity [GO:0038023]	cone photoreceptor outer segment [GO:0120199]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; G protein-coupled photoreceptor activity [GO:0008020]; signaling receptor activity [GO:0038023]; cellular response to light stimulus [GO:0071482]; cellular response to UV-A [GO:0071492]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2937147, ECO:0000269|PubMed:31380578, ECO:0000269|PubMed:31730232}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P51491}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P51491}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:30168605}.
P04000	reviewed	OPSR_HUMAN	Long-wave-sensitive opsin 1 (Red cone photoreceptor pigment) (Red-sensitive opsin) (ROP)	OPN1LW RCP	Homo sapiens (Human)	364	FUNCTION: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.		cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; positive regulation of cytokinesis [GO:0032467]; signal transduction [GO:0007165]; visual perception [GO:0007601]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]	G protein-coupled photoreceptor activity [GO:0008020]; photoreceptor activity [GO:0009881]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; G protein-coupled photoreceptor activity [GO:0008020]; photoreceptor activity [GO:0009881]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; positive regulation of cytokinesis [GO:0032467]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P04001	reviewed	OPSG_HUMAN	Medium-wave-sensitive opsin 1 (Green cone photoreceptor pigment) (Green-sensitive opsin) (GOP)	OPN1MW GCP	Homo sapiens (Human)	364	FUNCTION: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. {ECO:0000305|PubMed:12051694, ECO:0000305|PubMed:1302020, ECO:0000305|PubMed:2937147}.		cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; positive regulation of cytokinesis [GO:0032467]; visual perception [GO:0007601]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]	G protein-coupled photoreceptor activity [GO:0008020]; identical protein binding [GO:0042802]; photoreceptor activity [GO:0009881]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; G protein-coupled photoreceptor activity [GO:0008020]; identical protein binding [GO:0042802]; photoreceptor activity [GO:0009881]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; positive regulation of cytokinesis [GO:0032467]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20579627}; Multi-pass membrane protein {ECO:0000255}.
P04003	reviewed	C4BPA_HUMAN	C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP)	C4BPA C4BP	Homo sapiens (Human)	597	FUNCTION: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.		complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, classical pathway [GO:0045959]; positive regulation of protein catabolic process [GO:0045732]; regulation of opsonization [GO:1903027]; response to symbiotic bacterium [GO:0009609]; T cell mediated immunity [GO:0002456]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	RNA binding [GO:0003723]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, classical pathway [GO:0045959]; positive regulation of protein catabolic process [GO:0045732]; regulation of opsonization [GO:1903027]; response to symbiotic bacterium [GO:0009609]; T cell mediated immunity [GO:0002456]	SUBCELLULAR LOCATION: Secreted.
P04004	reviewed	VTNC_HUMAN	Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B]	VTN	Homo sapiens (Human)	478	FUNCTION: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.; FUNCTION: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.		cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; immune response [GO:0006955]; liver regeneration [GO:0097421]; negative regulation of blood coagulation [GO:0030195]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of fibrinolysis [GO:0051918]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of wound healing [GO:0090303]; protein polymerization [GO:0051258]; regulation of cell adhesion [GO:0030155]; smooth muscle cell-matrix adhesion [GO:0061302]	alphav-beta3 integrin-vitronectin complex [GO:0071062]; basement membrane [GO:0005604]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; peptidase inhibitor complex [GO:1904090]; protein complex involved in cell-matrix adhesion [GO:0098637]; rough endoplasmic reticulum lumen [GO:0048237]	collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]	alphav-beta3 integrin-vitronectin complex [GO:0071062]; basement membrane [GO:0005604]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; peptidase inhibitor complex [GO:1904090]; protein complex involved in cell-matrix adhesion [GO:0098637]; rough endoplasmic reticulum lumen [GO:0048237]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; immune response [GO:0006955]; liver regeneration [GO:0097421]; negative regulation of blood coagulation [GO:0030195]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of fibrinolysis [GO:0051918]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of wound healing [GO:0090303]; protein polymerization [GO:0051258]; regulation of cell adhesion [GO:0030155]; smooth muscle cell-matrix adhesion [GO:0061302]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:2448300, ECO:0000269|PubMed:29567995}.; SUBCELLULAR LOCATION: Parasitophorous vacuole {ECO:0000269|PubMed:29567995}. Note=(Microbial infection) In P.falciparum-infected red blood cells, VTN internalization is detected at the early trophozoite stage (PubMed:29567995). Colocalizes with SERA5 at the schizont stage and with SERA5 P47 at the merozoite surface (PubMed:29567995). {ECO:0000269|PubMed:29567995}.
P04035	reviewed	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)	HMGCR	Homo sapiens (Human)	888	FUNCTION: Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:2991281, PubMed:21357570, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668). {ECO:0000269|PubMed:11349148, ECO:0000269|PubMed:18540668, ECO:0000269|PubMed:21357570, ECO:0000269|PubMed:2991281, ECO:0000269|PubMed:6995544}.		cholesterol biosynthetic process [GO:0006695]; coenzyme A metabolic process [GO:0015936]; isoprenoid biosynthetic process [GO:0008299]; long-term synaptic potentiation [GO:0060291]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein secretion [GO:0050709]; regulation of ERK1 and ERK2 cascade [GO:0070372]; sterol biosynthetic process [GO:0016126]; visual learning [GO:0008542]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; peroxisomal membrane [GO:0005778]	coenzyme A binding [GO:0120225]; GTPase regulator activity [GO:0030695]; hydroxymethylglutaryl-CoA reductase (NADPH) activity [GO:0004420]; NADPH binding [GO:0070402]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; peroxisomal membrane [GO:0005778]; coenzyme A binding [GO:0120225]; GTPase regulator activity [GO:0030695]; hydroxymethylglutaryl-CoA reductase (NADPH) activity [GO:0004420]; NADPH binding [GO:0070402]; cholesterol biosynthetic process [GO:0006695]; coenzyme A metabolic process [GO:0015936]; isoprenoid biosynthetic process [GO:0008299]; long-term synaptic potentiation [GO:0060291]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein secretion [GO:0050709]; regulation of ERK1 and ERK2 cascade [GO:0070372]; sterol biosynthetic process [GO:0016126]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17180682, ECO:0000305|PubMed:2991281}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}. Peroxisome membrane {ECO:0000269|PubMed:17180682}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}.
P04040	reviewed	CATA_HUMAN	Catalase (EC 1.11.1.6)	CAT	Homo sapiens (Human)	527	FUNCTION: Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}.		aerobic respiration [GO:0009060]; cellular detoxification of hydrogen peroxide [GO:0061692]; cellular response to growth factor stimulus [GO:0071363]; cholesterol metabolic process [GO:0008203]; hemoglobin metabolic process [GO:0020027]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of apoptotic process [GO:0043066]; osteoblast differentiation [GO:0001649]; positive regulation of cell division [GO:0051781]; response to activity [GO:0014823]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to inactivity [GO:0014854]; response to insulin [GO:0032868]; response to L-ascorbic acid [GO:0033591]; response to lead ion [GO:0010288]; response to light intensity [GO:0009642]; response to ozone [GO:0010193]; response to phenylpropanoid [GO:0080184]; response to reactive oxygen species [GO:0000302]; response to vitamin A [GO:0033189]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; triglyceride metabolic process [GO:0006641]; ureteric bud development [GO:0001657]; UV protection [GO:0009650]	catalase complex [GO:0062151]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]	aminoacylase activity [GO:0004046]; antioxidant activity [GO:0016209]; catalase activity [GO:0004096]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; protein homodimerization activity [GO:0042803]	catalase complex [GO:0062151]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; aminoacylase activity [GO:0004046]; antioxidant activity [GO:0016209]; catalase activity [GO:0004096]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; protein homodimerization activity [GO:0042803]; aerobic respiration [GO:0009060]; cellular detoxification of hydrogen peroxide [GO:0061692]; cellular response to growth factor stimulus [GO:0071363]; cholesterol metabolic process [GO:0008203]; hemoglobin metabolic process [GO:0020027]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of apoptotic process [GO:0043066]; osteoblast differentiation [GO:0001649]; positive regulation of cell division [GO:0051781]; response to activity [GO:0014823]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to inactivity [GO:0014854]; response to insulin [GO:0032868]; response to L-ascorbic acid [GO:0033591]; response to lead ion [GO:0010288]; response to light intensity [GO:0009642]; response to ozone [GO:0010193]; response to phenylpropanoid [GO:0080184]; response to reactive oxygen species [GO:0000302]; response to vitamin A [GO:0033189]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; triglyceride metabolic process [GO:0006641]; ureteric bud development [GO:0001657]; UV protection [GO:0009650]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:21976670, ECO:0000269|PubMed:8769411}.
P04049	reviewed	RAF1_HUMAN	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)	RAF1 RAF	Homo sapiens (Human)	648	FUNCTION: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.		activation of adenylate cyclase activity [GO:0007190]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; death-inducing signaling complex assembly [GO:0071550]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intermediate filament cytoskeleton organization [GO:0045104]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of protein-containing complex assembly [GO:0031333]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of cell differentiation [GO:0045595]; regulation of cell motility [GO:2000145]; regulation of Rho protein signal transduction [GO:0035023]; response to muscle stretch [GO:0035994]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; type B pancreatic cell proliferation [GO:0044342]; type II interferon-mediated signaling pathway [GO:0060333]; wound healing [GO:0042060]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; activation of adenylate cyclase activity [GO:0007190]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; death-inducing signaling complex assembly [GO:0071550]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intermediate filament cytoskeleton organization [GO:0045104]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of protein-containing complex assembly [GO:0031333]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of cell differentiation [GO:0045595]; regulation of cell motility [GO:2000145]; regulation of Rho protein signal transduction [GO:0035023]; response to muscle stretch [GO:0035994]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; type B pancreatic cell proliferation [GO:0044342]; type II interferon-mediated signaling pathway [GO:0060333]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Mitochondrion. Nucleus. Note=Colocalizes with RGS14 and BRAF in both the cytoplasm and membranes. Phosphorylation at Ser-259 impairs its membrane accumulation. Recruited to the cell membrane by the active Ras protein. Phosphorylation at Ser-338 and Ser-339 by PAK1 is required for its mitochondrial localization. Retinoic acid-induced Ser-621 phosphorylated form of RAF1 is predominantly localized at the nucleus.
P04053	reviewed	TDT_HUMAN	DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltransferase) (Terminal transferase)	DNTT TDT	Homo sapiens (Human)	509	FUNCTION: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. {ECO:0000250|UniProtKB:P09838}.		DNA metabolic process [GO:0006259]; DNA modification [GO:0006304]; double-strand break repair via nonhomologous end joining [GO:0006303]; response to ATP [GO:0033198]	cytosol [GO:0005829]; euchromatin [GO:0000791]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA nucleotidylexotransferase activity [GO:0003912]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; euchromatin [GO:0000791]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA nucleotidylexotransferase activity [GO:0003912]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; DNA metabolic process [GO:0006259]; DNA modification [GO:0006304]; double-strand break repair via nonhomologous end joining [GO:0006303]; response to ATP [GO:0033198]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16371131}.
P04054	reviewed	PA21B_HUMAN	Phospholipase A2 (EC 3.1.1.4) (Group IB phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 1B)	PLA2G1B PLA2 PLA2A PPLA2	Homo sapiens (Human)	148	FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:1420353, PubMed:10681567, PubMed:17603006). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:1420353, PubMed:10681567, PubMed:17603006). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (PubMed:7721806, PubMed:25335547). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (PubMed:25335547). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity). {ECO:0000250|UniProtKB:P04055, ECO:0000250|UniProtKB:Q9Z0Y2, ECO:0000269|PubMed:10681567, ECO:0000269|PubMed:1420353, ECO:0000269|PubMed:17603006, ECO:0000269|PubMed:25335547, ECO:0000269|PubMed:7721806}.		actin filament organization [GO:0007015]; activation of phospholipase A2 activity [GO:0032431]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; arachidonic acid secretion [GO:0050482]; cellular response to insulin stimulus [GO:0032869]; defense response to Gram-positive bacterium [GO:0050830]; fatty acid biosynthetic process [GO:0006633]; innate immune response in mucosa [GO:0002227]; intracellular signal transduction [GO:0035556]; leukotriene biosynthetic process [GO:0019370]; lipid catabolic process [GO:0016042]; neutrophil chemotaxis [GO:0030593]; neutrophil mediated immunity [GO:0002446]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of immune response [GO:0050778]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of podocyte apoptotic process [GO:1904635]; positive regulation of protein secretion [GO:0050714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of glucose import [GO:0046324]; signal transduction [GO:0007165]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	bile acid binding [GO:0032052]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; bile acid binding [GO:0032052]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102]; actin filament organization [GO:0007015]; activation of phospholipase A2 activity [GO:0032431]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; arachidonic acid secretion [GO:0050482]; cellular response to insulin stimulus [GO:0032869]; defense response to Gram-positive bacterium [GO:0050830]; fatty acid biosynthetic process [GO:0006633]; innate immune response in mucosa [GO:0002227]; intracellular signal transduction [GO:0035556]; leukotriene biosynthetic process [GO:0019370]; lipid catabolic process [GO:0016042]; neutrophil chemotaxis [GO:0030593]; neutrophil mediated immunity [GO:0002446]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of immune response [GO:0050778]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of podocyte apoptotic process [GO:1904635]; positive regulation of protein secretion [GO:0050714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of glucose import [GO:0046324]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19297324}. Note=Secreted from pancreatic acinar cells in its inactive form.
P04062	reviewed	GBA1_HUMAN	Lysosomal acid glucosylceramidase (Lysosomal acid GCase) (EC 3.2.1.45) (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (Beta-GC) (Beta-glucosylceramidase 1) (Cholesterol glucosyltransferase) (SGTase) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase) (EC 3.2.1.-) (D-glucosyl-N-acylsphingosine glucohydrolase) (Glucosylceramidase beta 1) (Imiglucerase) (Lysosomal cholesterol glycosyltransferase) (Lysosomal galactosylceramidase) (EC 3.2.1.46) (Lysosomal glycosylceramidase)	GBA1 GBA GC GLUC	Homo sapiens (Human)	536	FUNCTION: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose (PubMed:9201993, PubMed:24211208, PubMed:15916907, PubMed:32144204). Plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698). Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation (PubMed:19279011). Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol (PubMed:24211208, PubMed:26724485, PubMed:32144204). GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine) (PubMed:24211208). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide (PubMed:26724485) (Probable). Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol (PubMed:24211208, PubMed:26724485). Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers (PubMed:32144204). Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside (PubMed:33361282). {ECO:0000269|PubMed:15916907, ECO:0000269|PubMed:19279011, ECO:0000269|PubMed:24211208, ECO:0000269|PubMed:26724485, ECO:0000269|PubMed:27378698, ECO:0000269|PubMed:32144204, ECO:0000269|PubMed:33361282, ECO:0000269|PubMed:9201993, ECO:0000305|PubMed:32144204}.	MISCELLANEOUS: [Isoform Long]: Major isoform. {ECO:0000269|PubMed:3687939}.; MISCELLANEOUS: [Isoform Short]: Produced by alternative initiation from a downstream AUG. Two to three times less protein is produced from this downstream AUG. {ECO:0000269|PubMed:3687939}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing. {ECO:0000305}.	antigen processing and presentation [GO:0019882]; autophagosome organization [GO:1905037]; autophagy [GO:0006914]; beta-glucoside catabolic process [GO:1901805]; brain morphogenesis [GO:0048854]; cell maturation [GO:0048469]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; cerebellar Purkinje cell layer formation [GO:0021694]; cholesterol metabolic process [GO:0008203]; determination of adult lifespan [GO:0008340]; establishment of skin barrier [GO:0061436]; glucosylceramide catabolic process [GO:0006680]; hematopoietic stem cell proliferation [GO:0071425]; homeostasis of number of cells [GO:0048872]; lipid glycosylation [GO:0030259]; lipid storage [GO:0019915]; lymphocyte migration [GO:0072676]; lysosome organization [GO:0007040]; microglia differentiation [GO:0014004]; microglial cell proliferation [GO:0061518]; motor behavior [GO:0061744]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein-containing complex assembly [GO:0031333]; neuromuscular process [GO:0050905]; neuron apoptotic process [GO:0051402]; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [GO:1904925]; positive regulation of neuronal action potential [GO:1904457]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein lipidation [GO:1903061]; positive regulation of protein-containing complex disassembly [GO:0043243]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; pyramidal neuron differentiation [GO:0021859]; regulation of lysosomal protein catabolic process [GO:1905165]; regulation of macroautophagy [GO:0016241]; regulation of TOR signaling [GO:0032006]; respiratory electron transport chain [GO:0022904]; response to dexamethasone [GO:0071548]; response to estrogen [GO:0043627]; response to pH [GO:0009268]; response to testosterone [GO:0033574]; response to thyroid hormone [GO:0097066]; sphingosine biosynthetic process [GO:0046512]; T cell differentiation in thymus [GO:0033077]; termination of signal transduction [GO:0023021]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; trans-Golgi network [GO:0005802]	galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glucosyltransferase activity [GO:0046527]; scavenger receptor binding [GO:0005124]; signaling receptor binding [GO:0005102]; steryl-beta-glucosidase activity [GO:0050295]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; trans-Golgi network [GO:0005802]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glucosyltransferase activity [GO:0046527]; scavenger receptor binding [GO:0005124]; signaling receptor binding [GO:0005102]; steryl-beta-glucosidase activity [GO:0050295]; antigen processing and presentation [GO:0019882]; autophagosome organization [GO:1905037]; autophagy [GO:0006914]; beta-glucoside catabolic process [GO:1901805]; brain morphogenesis [GO:0048854]; cell maturation [GO:0048469]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; cerebellar Purkinje cell layer formation [GO:0021694]; cholesterol metabolic process [GO:0008203]; determination of adult lifespan [GO:0008340]; establishment of skin barrier [GO:0061436]; glucosylceramide catabolic process [GO:0006680]; hematopoietic stem cell proliferation [GO:0071425]; homeostasis of number of cells [GO:0048872]; lipid glycosylation [GO:0030259]; lipid storage [GO:0019915]; lymphocyte migration [GO:0072676]; lysosome organization [GO:0007040]; microglia differentiation [GO:0014004]; microglial cell proliferation [GO:0061518]; motor behavior [GO:0061744]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein-containing complex assembly [GO:0031333]; neuromuscular process [GO:0050905]; neuron apoptotic process [GO:0051402]; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [GO:1904925]; positive regulation of neuronal action potential [GO:1904457]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein lipidation [GO:1903061]; positive regulation of protein-containing complex disassembly [GO:0043243]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; pyramidal neuron differentiation [GO:0021859]; regulation of lysosomal protein catabolic process [GO:1905165]; regulation of macroautophagy [GO:0016241]; regulation of TOR signaling [GO:0032006]; respiratory electron transport chain [GO:0022904]; response to dexamethasone [GO:0071548]; response to estrogen [GO:0043627]; response to pH [GO:0009268]; response to testosterone [GO:0033574]; response to thyroid hormone [GO:0097066]; sphingosine biosynthetic process [GO:0046512]; T cell differentiation in thymus [GO:0033077]; termination of signal transduction [GO:0023021]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17187079, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:18022370}; Peripheral membrane protein {ECO:0000269|PubMed:10781797, ECO:0000269|PubMed:18022370, ECO:0000269|PubMed:1848227}; Lumenal side {ECO:0000269|PubMed:18022370}. Note=Interaction with saposin-C promotes membrane association (PubMed:10781797). Targeting to lysosomes occurs through an alternative MPR-independent mechanism via SCARB2 (PubMed:18022370). {ECO:0000269|PubMed:10781797, ECO:0000269|PubMed:18022370}.
P04066	reviewed	FUCO_HUMAN	Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1)	FUCA1 Nbla10230	Homo sapiens (Human)	466	FUNCTION: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. {ECO:0000269|PubMed:9741689}.		fucose metabolic process [GO:0006004]; glycolipid catabolic process [GO:0019377]; glycosaminoglycan catabolic process [GO:0006027]; glycoside catabolic process [GO:0016139]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	alpha-L-fucosidase activity [GO:0004560]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; alpha-L-fucosidase activity [GO:0004560]; fucose metabolic process [GO:0006004]; glycolipid catabolic process [GO:0019377]; glycosaminoglycan catabolic process [GO:0006027]; glycoside catabolic process [GO:0016139]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:9741689}.
P04070	reviewed	PROC_HUMAN	Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]	PROC	Homo sapiens (Human)	461	FUNCTION: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845). {ECO:0000269|PubMed:25618265, ECO:0000269|PubMed:25651845}.	MISCELLANEOUS: Calcium also binds, with stronger affinity to another site, beyond the GLA domain. This GLA-independent binding site is necessary for the recognition of the thrombin-thrombomodulin complex.	blood coagulation [GO:0007596]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood coagulation [GO:0030195]; negative regulation of coagulation [GO:0050819]; negative regulation of inflammatory response [GO:0050728]; positive regulation of establishment of endothelial barrier [GO:1903142]; proteolysis [GO:0006508]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]	calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; blood coagulation [GO:0007596]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood coagulation [GO:0030195]; negative regulation of coagulation [GO:0050819]; negative regulation of inflammatory response [GO:0050728]; positive regulation of establishment of endothelial barrier [GO:1903142]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25618265}. Golgi apparatus {ECO:0000269|PubMed:22531345, ECO:0000269|PubMed:25748729}. Endoplasmic reticulum {ECO:0000269|PubMed:22531345, ECO:0000269|PubMed:25748729}.
P04075	reviewed	ALDOA_HUMAN	Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase)	ALDOA ALDA	Homo sapiens (Human)	364	FUNCTION: Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}.	MISCELLANEOUS: In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.	actin filament organization [GO:0007015]; ATP biosynthetic process [GO:0006754]; binding of sperm to zona pellucida [GO:0007339]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose metabolic process [GO:0006000]; glycolytic process [GO:0006096]; muscle cell cellular homeostasis [GO:0046716]; protein homotetramerization [GO:0051289]; regulation of cell shape [GO:0008360]; striated muscle contraction [GO:0006941]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; I band [GO:0031674]; M band [GO:0031430]; membrane [GO:0016020]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774]; sperm head [GO:0061827]; tertiary granule lumen [GO:1904724]	actin binding [GO:0003779]; cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; fructose binding [GO:0070061]; fructose-bisphosphate aldolase activity [GO:0004332]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; tubulin binding [GO:0015631]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; I band [GO:0031674]; M band [GO:0031430]; membrane [GO:0016020]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774]; sperm head [GO:0061827]; tertiary granule lumen [GO:1904724]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; fructose binding [GO:0070061]; fructose-bisphosphate aldolase activity [GO:0004332]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; tubulin binding [GO:0015631]; actin filament organization [GO:0007015]; ATP biosynthetic process [GO:0006754]; binding of sperm to zona pellucida [GO:0007339]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose metabolic process [GO:0006000]; glycolytic process [GO:0006096]; muscle cell cellular homeostasis [GO:0046716]; protein homotetramerization [GO:0051289]; regulation of cell shape [GO:0008360]; striated muscle contraction [GO:0006941]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:P00883}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:P00883}. Note=In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). {ECO:0000250|UniProtKB:P00883}.
P04080	reviewed	CYTB_HUMAN	Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B)	CSTB CST6 STFB	Homo sapiens (Human)	98	FUNCTION: This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.		adult locomotory behavior [GO:0008344]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nucleolus [GO:0005730]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; protease binding [GO:0002020]; RNA binding [GO:0003723]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nucleolus [GO:0005730]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; protease binding [GO:0002020]; RNA binding [GO:0003723]; adult locomotory behavior [GO:0008344]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11139332}. Nucleus {ECO:0000269|PubMed:11139332}.
P04083	reviewed	ANXA1_HUMAN	Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]	ANXA1 ANX1 LPC1	Homo sapiens (Human)	346	FUNCTION: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:22879591, PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}.	MISCELLANEOUS: Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)-dependent binding to phospholipid membranes and can promote membrane aggregation in vitro. Was initially identified as inhibitor of phospholipase A2 activity (in vitro) (PubMed:2936963, PubMed:8425544). Inhibition of phospholipase activity is mediated via its phospholipid binding activity that limits the access of phospholipase to its substrates. {ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; adaptive immune response [GO:0002250]; alpha-beta T cell differentiation [GO:0046632]; arachidonic acid secretion [GO:0050482]; cell surface receptor signaling pathway [GO:0007166]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; DNA duplex unwinding [GO:0032508]; endocrine pancreas development [GO:0031018]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gliogenesis [GO:0042063]; granulocyte chemotaxis [GO:0071621]; hepatocyte differentiation [GO:0070365]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; insulin secretion [GO:0030073]; keratinocyte differentiation [GO:0030216]; localization [GO:0051179]; monocyte chemotaxis [GO:0002548]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of apoptotic process [GO:0043066]; negative regulation of exocytosis [GO:0045920]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; neutrophil activation [GO:0042119]; neutrophil clearance [GO:0097350]; neutrophil homeostasis [GO:0001780]; peptide cross-linking [GO:0018149]; phagocytosis [GO:0006909]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; positive regulation of vesicle fusion [GO:0031340]; positive regulation of wound healing [GO:0090303]; prolactin secretion [GO:0070459]; prostate gland development [GO:0030850]; regulation of cell shape [GO:0008360]; regulation of hormone secretion [GO:0046883]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-1 production [GO:0032652]; regulation of leukocyte migration [GO:0002685]; response to estradiol [GO:0032355]; response to interleukin-1 [GO:0070555]; response to peptide hormone [GO:0043434]; response to X-ray [GO:0010165]; signal transduction [GO:0007165]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lateral plasma membrane [GO:0016328]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; vesicle [GO:0031982]	cadherin binding involved in cell-cell adhesion [GO:0098641]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; lipid binding [GO:0008289]; phospholipase A2 inhibitor activity [GO:0019834]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lateral plasma membrane [GO:0016328]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; vesicle [GO:0031982]; cadherin binding involved in cell-cell adhesion [GO:0098641]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; lipid binding [GO:0008289]; phospholipase A2 inhibitor activity [GO:0019834]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102]; actin cytoskeleton organization [GO:0030036]; adaptive immune response [GO:0002250]; alpha-beta T cell differentiation [GO:0046632]; arachidonic acid secretion [GO:0050482]; cell surface receptor signaling pathway [GO:0007166]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; DNA duplex unwinding [GO:0032508]; endocrine pancreas development [GO:0031018]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gliogenesis [GO:0042063]; granulocyte chemotaxis [GO:0071621]; hepatocyte differentiation [GO:0070365]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; insulin secretion [GO:0030073]; keratinocyte differentiation [GO:0030216]; localization [GO:0051179]; monocyte chemotaxis [GO:0002548]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of apoptotic process [GO:0043066]; negative regulation of exocytosis [GO:0045920]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; neutrophil activation [GO:0042119]; neutrophil clearance [GO:0097350]; neutrophil homeostasis [GO:0001780]; peptide cross-linking [GO:0018149]; phagocytosis [GO:0006909]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; positive regulation of vesicle fusion [GO:0031340]; positive regulation of wound healing [GO:0090303]; prolactin secretion [GO:0070459]; prostate gland development [GO:0030850]; regulation of cell shape [GO:0008360]; regulation of hormone secretion [GO:0046883]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-1 production [GO:0032652]; regulation of leukocyte migration [GO:0002685]; response to estradiol [GO:0032355]; response to interleukin-1 [GO:0070555]; response to peptide hormone [GO:0043434]; response to X-ray [GO:0010165]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10772777, ECO:0000269|PubMed:19625660}. Cytoplasm {ECO:0000269|PubMed:10772777, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660}. Cell projection, cilium {ECO:0000250|UniProtKB:P46193}. Cell membrane {ECO:0000269|PubMed:10772777}. Membrane {ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:8557678}; Peripheral membrane protein {ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:8557678}. Endosome membrane {ECO:0000250|UniProtKB:P07150}; Peripheral membrane protein {ECO:0000250|UniProtKB:P07150}. Basolateral cell membrane {ECO:0000250|UniProtKB:P51662}. Apical cell membrane {ECO:0000250|UniProtKB:P10107}. Lateral cell membrane {ECO:0000250|UniProtKB:P10107}. Secreted {ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:25664854}. Secreted, extracellular space {ECO:0000269|PubMed:25664854}. Cell membrane {ECO:0000269|PubMed:10772777, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:25664854}; Peripheral membrane protein {ECO:0000269|PubMed:10772777, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:25664854}; Extracellular side {ECO:0000269|PubMed:10772777, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:25664854}. Secreted, extracellular exosome {ECO:0000269|PubMed:25664854}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000269|PubMed:10772777}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:P10107}. Early endosome {ECO:0000250|UniProtKB:P19619}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P19619}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19619}. Note=Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Alternatively, the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in the protein translocation from the cytoplasm into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). {ECO:0000250|UniProtKB:P10107, ECO:0000269|PubMed:10772777, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:25664854, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:8557678}.
P04085	reviewed	PDGFA_HUMAN	Platelet-derived growth factor subunit A (PDGF subunit A) (PDGF-1) (Platelet-derived growth factor A chain) (Platelet-derived growth factor alpha polypeptide)	PDGFA PDGF1	Homo sapiens (Human)	211	FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). {ECO:0000250}.		actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cell activation [GO:0001775]; cell projection assembly [GO:0030031]; cell-cell signaling [GO:0007267]; embryonic lung development [GO:1990401]; hair follicle development [GO:0001942]; lung alveolus development [GO:0048286]; negative chemotaxis [GO:0050919]; negative regulation of phosphatidylinositol biosynthetic process [GO:0010512]; negative regulation of platelet activation [GO:0010544]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-alpha signaling pathway [GO:0035790]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein autophosphorylation [GO:0031954]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling [GO:0060683]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of smooth muscle cell migration [GO:0014910]; response to wounding [GO:0009611]; skin development [GO:0043588]; wound healing [GO:0042060]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; microvillus [GO:0005902]; platelet alpha granule lumen [GO:0031093]; platelet-derived growth factor complex [GO:1990265]	collagen binding [GO:0005518]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; microvillus [GO:0005902]; platelet alpha granule lumen [GO:0031093]; platelet-derived growth factor complex [GO:1990265]; collagen binding [GO:0005518]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cell activation [GO:0001775]; cell projection assembly [GO:0030031]; cell-cell signaling [GO:0007267]; embryonic lung development [GO:1990401]; hair follicle development [GO:0001942]; lung alveolus development [GO:0048286]; negative chemotaxis [GO:0050919]; negative regulation of phosphatidylinositol biosynthetic process [GO:0010512]; negative regulation of platelet activation [GO:0010544]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-alpha signaling pathway [GO:0035790]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein autophosphorylation [GO:0031954]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling [GO:0060683]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of smooth muscle cell migration [GO:0014910]; response to wounding [GO:0009611]; skin development [GO:0043588]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Secreted. Note=Released by platelets upon wounding.
P04090	reviewed	REL2_HUMAN	Prorelaxin H2 [Cleaved into: Relaxin B chain; Relaxin A chain]	RLN2	Homo sapiens (Human)	185	FUNCTION: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.		female pregnancy [GO:0007565]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; regulation of catalytic activity [GO:0050790]	extracellular region [GO:0005576]	hormone activity [GO:0005179]	extracellular region [GO:0005576]; hormone activity [GO:0005179]; female pregnancy [GO:0007565]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; regulation of catalytic activity [GO:0050790]	SUBCELLULAR LOCATION: Secreted.
P04114	reviewed	APOB_HUMAN	Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)]	APOB	Homo sapiens (Human)	4563	FUNCTION: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.		artery morphogenesis [GO:0048844]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; in utero embryonic development [GO:0001701]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein catabolic process [GO:0042159]; lipoprotein transport [GO:0042953]; low-density lipoprotein particle clearance [GO:0034383]; low-density lipoprotein particle remodeling [GO:0034374]; nervous system development [GO:0007399]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; post-embryonic development [GO:0009791]; regulation of cholesterol biosynthetic process [GO:0045540]; response to virus [GO:0009615]; spermatogenesis [GO:0007283]; triglyceride catabolic process [GO:0019433]; triglyceride mobilization [GO:0006642]; very-low-density lipoprotein particle assembly [GO:0034379]	chylomicron [GO:0042627]; chylomicron remnant [GO:0034360]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endosome lumen [GO:0031904]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intermediate-density lipoprotein particle [GO:0034363]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; low-density lipoprotein particle [GO:0034362]; lysosomal lumen [GO:0043202]; mature chylomicron [GO:0034359]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; very-low-density lipoprotein particle [GO:0034361]	cholesterol transfer activity [GO:0120020]; heparin binding [GO:0008201]; lipase binding [GO:0035473]; low-density lipoprotein particle receptor binding [GO:0050750]; phospholipid binding [GO:0005543]	chylomicron [GO:0042627]; chylomicron remnant [GO:0034360]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endosome lumen [GO:0031904]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intermediate-density lipoprotein particle [GO:0034363]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; low-density lipoprotein particle [GO:0034362]; lysosomal lumen [GO:0043202]; mature chylomicron [GO:0034359]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; very-low-density lipoprotein particle [GO:0034361]; cholesterol transfer activity [GO:0120020]; heparin binding [GO:0008201]; lipase binding [GO:0035473]; low-density lipoprotein particle receptor binding [GO:0050750]; phospholipid binding [GO:0005543]; artery morphogenesis [GO:0048844]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; in utero embryonic development [GO:0001701]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein catabolic process [GO:0042159]; lipoprotein transport [GO:0042953]; low-density lipoprotein particle clearance [GO:0034383]; low-density lipoprotein particle remodeling [GO:0034374]; nervous system development [GO:0007399]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; post-embryonic development [GO:0009791]; regulation of cholesterol biosynthetic process [GO:0045540]; response to virus [GO:0009615]; spermatogenesis [GO:0007283]; triglyceride catabolic process [GO:0019433]; triglyceride mobilization [GO:0006642]; very-low-density lipoprotein particle assembly [GO:0034379]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22580899}. Secreted {ECO:0000269|PubMed:22580899, ECO:0000269|PubMed:26224785}. Lipid droplet {ECO:0000269|PubMed:28183703}.
P04118	reviewed	COL_HUMAN	Colipase	CLPS	Homo sapiens (Human)	112	FUNCTION: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. {ECO:0000269|PubMed:17401110, ECO:0000269|PubMed:26494624}.; FUNCTION: Enterostatin has a biological activity as a satiety signal. {ECO:0000305}.		digestion [GO:0007586]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; response to bacterium [GO:0009617]; response to food [GO:0032094]	extracellular region [GO:0005576]	enzyme activator activity [GO:0008047]; lipase binding [GO:0035473]	extracellular region [GO:0005576]; enzyme activator activity [GO:0008047]; lipase binding [GO:0035473]; digestion [GO:0007586]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; response to bacterium [GO:0009617]; response to food [GO:0032094]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P04141	reviewed	CSF2_HUMAN	Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (Molgramostin) (Sargramostim)	CSF2 GMCSF	Homo sapiens (Human)	144	FUNCTION: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. {ECO:0000269|PubMed:3925454}.		cell population proliferation [GO:0008283]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell differentiation [GO:0097028]; embryonic placenta development [GO:0001892]; epithelial fluid transport [GO:0042045]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; histamine secretion [GO:0001821]; immune response [GO:0006955]; macrophage differentiation [GO:0030225]; monocyte differentiation [GO:0030224]; myeloid cell differentiation [GO:0030099]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; neutrophil differentiation [GO:0030223]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of leukocyte proliferation [GO:0070665]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of podosome assembly [GO:0071803]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; response to fluid shear stress [GO:0034405]; response to silicon dioxide [GO:0034021]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; granulocyte macrophage colony-stimulating factor receptor binding [GO:0005129]; growth factor activity [GO:0008083]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; granulocyte macrophage colony-stimulating factor receptor binding [GO:0005129]; growth factor activity [GO:0008083]; cell population proliferation [GO:0008283]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell differentiation [GO:0097028]; embryonic placenta development [GO:0001892]; epithelial fluid transport [GO:0042045]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; histamine secretion [GO:0001821]; immune response [GO:0006955]; macrophage differentiation [GO:0030225]; monocyte differentiation [GO:0030224]; myeloid cell differentiation [GO:0030099]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; neutrophil differentiation [GO:0030223]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of leukocyte proliferation [GO:0070665]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of podosome assembly [GO:0071803]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; response to fluid shear stress [GO:0034405]; response to silicon dioxide [GO:0034021]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1737041, ECO:0000269|PubMed:3925454}.
P04150	reviewed	GCR_HUMAN	Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)	NR3C1 GRL	Homo sapiens (Human)	777	FUNCTION: Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:15866175, PubMed:19248771, PubMed:20484466, PubMed:23820903, PubMed:11435610, PubMed:15769988, PubMed:17635946, PubMed:19141540, PubMed:21664385). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:7769088, PubMed:8621628, PubMed:20484466). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.	MISCELLANEOUS: [Isoform Beta]: High constitutive expression by neutrophils may provide a mechanism by which these cells escape glucocorticoid-induced cell death and up-regulation by pro-inflammatory cytokines such as IL8 further enhances their survival in the presence of glucocorticoids during inflammation. {ECO:0000269|PubMed:11238589}.; MISCELLANEOUS: Can up- or down-modulate aggregation and nuclear localization of expanded polyglutamine polypeptides derived from AR and HD through specific regulation of gene expression. Aggregation and nuclear localization of expanded polyglutamine proteins are regulated cellular processes that can be modulated by this receptor, a well-characterized transcriptional regulator. {ECO:0000269|PubMed:10639135}.; MISCELLANEOUS: [Isoform Alpha]: Predominant physiological form. {ECO:0000269|PubMed:15866175}.; MISCELLANEOUS: [Isoform Alpha-2]: Due to a partial intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform Beta-2]: Due to a partial intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform GR-A alpha]: Lacks exons 5, 6 and 7. Found in glucocorticoid-resistant myeloma patients. {ECO:0000269|PubMed:8358712}.; MISCELLANEOUS: [Isoform GR-A beta]: Lacks exons 5, 6 and 7. {ECO:0000269|PubMed:8358712}.; MISCELLANEOUS: [Isoform GR-P]: Encoded by exons 2-7 plus several basepairs from the subsequent intron region. Lacks the ligand binding domain. Accounts for up to 10-20% of mRNAs. {ECO:0000269|PubMed:8358712}.; MISCELLANEOUS: [Isoform Alpha-B]: Produced by alternative initiation at Met-27 of isoform Alpha. {ECO:0000305}.; MISCELLANEOUS: [Isoform Beta-B]: Produced by alternative initiation at Met-27 of isoform Beta. {ECO:0000269|PubMed:15866175, ECO:0000305}.; MISCELLANEOUS: [Isoform Alpha-C1]: Produced by alternative initiation at Met-86 of isoform Alpha. {ECO:0000269|PubMed:15866175}.; MISCELLANEOUS: [Isoform Alpha-C2]: Produced by alternative initiation at Met-90 of isoform Alpha. {ECO:0000269|PubMed:15866175}.; MISCELLANEOUS: [Isoform Alpha-C3]: Produced by alternative initiation at Met-98 of isoform Alpha. {ECO:0000269|PubMed:15866175}.; MISCELLANEOUS: [Isoform Alpha-D1]: Produced by alternative initiation at Met-316 of isoform Alpha. {ECO:0000269|PubMed:15866175}.; MISCELLANEOUS: [Isoform Alpha-D2]: Produced by alternative initiation at Met-331 of isoform Alpha. {ECO:0000269|PubMed:15866175}.; MISCELLANEOUS: [Isoform Alpha-D3]: Produced by alternative initiation at Met-336 of isoform Alpha. {ECO:0000269|PubMed:15866175}.	adrenal gland development [GO:0030325]; apoptotic process [GO:0006915]; astrocyte differentiation [GO:0048708]; cell division [GO:0051301]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chromatin organization [GO:0006325]; chromosome segregation [GO:0007059]; gene expression [GO:0010467]; glucocorticoid metabolic process [GO:0008211]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; mammary gland duct morphogenesis [GO:0060603]; maternal behavior [GO:0042711]; microglia differentiation [GO:0014004]; motor behavior [GO:0061744]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroinflammatory response [GO:0150076]; nucleus localization [GO:0051647]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucocorticoid biosynthetic process [GO:0031946]; regulation of gluconeogenesis [GO:0006111]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; mitochondrial matrix [GO:0005759]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; synapse [GO:0045202]	core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; estrogen response element binding [GO:0034056]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; nuclear glucocorticoid receptor activity [GO:0004883]; nuclear receptor activity [GO:0004879]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; steroid hormone binding [GO:1990239]; TBP-class protein binding [GO:0017025]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; mitochondrial matrix [GO:0005759]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; synapse [GO:0045202]; core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; estrogen response element binding [GO:0034056]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; nuclear glucocorticoid receptor activity [GO:0004883]; nuclear receptor activity [GO:0004879]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; steroid hormone binding [GO:1990239]; TBP-class protein binding [GO:0017025]; zinc ion binding [GO:0008270]; adrenal gland development [GO:0030325]; apoptotic process [GO:0006915]; astrocyte differentiation [GO:0048708]; cell division [GO:0051301]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chromatin organization [GO:0006325]; chromosome segregation [GO:0007059]; gene expression [GO:0010467]; glucocorticoid metabolic process [GO:0008211]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; mammary gland duct morphogenesis [GO:0060603]; maternal behavior [GO:0042711]; microglia differentiation [GO:0014004]; motor behavior [GO:0061744]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroinflammatory response [GO:0150076]; nucleus localization [GO:0051647]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucocorticoid biosynthetic process [GO:0031946]; regulation of gluconeogenesis [GO:0006111]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: [Isoform Alpha]: Cytoplasm {ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:18838540, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:8621628}. Nucleus {ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:18838540, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:8621628}. Mitochondrion {ECO:0000269|PubMed:21664385}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25847991}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25847991}. Note=After ligand activation, translocates from the cytoplasm to the nucleus. In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (By similarity). Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:18838540, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:8621628}.; SUBCELLULAR LOCATION: [Isoform Beta]: Nucleus {ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:8621628}. Cytoplasm {ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:26711253}. Note=Expressed predominantly in the nucleus with some expression also detected in the cytoplasm. {ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:26711253}.; SUBCELLULAR LOCATION: [Isoform Alpha-B]: Nucleus {ECO:0000269|PubMed:15866175}. Cytoplasm {ECO:0000269|PubMed:15866175}. Note=After ligand activation, translocates from the cytoplasm to the nucleus. {ECO:0000269|PubMed:15866175}.
P04155	reviewed	TFF1_HUMAN	Trefoil factor 1 (Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2)	TFF1 BCEI PS2	Homo sapiens (Human)	84	FUNCTION: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. {ECO:0000269|PubMed:16308573}.		carbohydrate metabolic process [GO:0005975]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of cell population proliferation [GO:0008285]; response to immobilization stress [GO:0035902]; response to iron ion [GO:0010039]; response to peptide hormone [GO:0043434]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	growth factor activity [GO:0008083]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth factor activity [GO:0008083]; carbohydrate metabolic process [GO:0005975]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of cell population proliferation [GO:0008285]; response to immobilization stress [GO:0035902]; response to iron ion [GO:0010039]; response to peptide hormone [GO:0043434]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15924415, ECO:0000269|PubMed:3041593}.
P04156	reviewed	PRIO_HUMAN	Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)	PRNP ALTPRP PRIP PRP	Homo sapiens (Human)	253	FUNCTION: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity). {ECO:0000250|UniProtKB:P04925, ECO:0000269|PubMed:12732622, ECO:0000269|PubMed:19936054, ECO:0000269|PubMed:20564047, ECO:0000305}.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the alternative prion protein/AltPrP (AC F7VJQ1) from an overlapping reading frame. {ECO:0000305|PubMed:21478263}.; MISCELLANEOUS: The alternative prion protein/AltPrP (AC F7VJQ1) and PRNP have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP. In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon. {ECO:0000305}.	calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell cycle [GO:0007049]; cellular response to amyloid-beta [GO:1904646]; cellular response to copper ion [GO:0071280]; cellular response to xenobiotic stimulus [GO:0071466]; dendritic spine maintenance [GO:0097062]; intracellular copper ion homeostasis [GO:0006878]; learning or memory [GO:0007611]; long-term memory [GO:0007616]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of dendritic spine maintenance [GO:1902951]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein processing [GO:0010955]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of type II interferon production [GO:0032689]; neuron projection maintenance [GO:1990535]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of protein tyrosine kinase activity [GO:0061098]; protein destabilization [GO:0031648]; protein homooligomerization [GO:0051260]; regulation of calcium ion import across plasma membrane [GO:1905664]; regulation of cell cycle [GO:0051726]; regulation of glutamate receptor signaling pathway [GO:1900449]; regulation of intracellular calcium activated chloride channel activity [GO:1902938]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of potassium ion transmembrane transport [GO:1901379]; response to amyloid-beta [GO:1904645]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; Golgi apparatus [GO:0005794]; inclusion body [GO:0016234]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; terminal bouton [GO:0043195]	amyloid-beta binding [GO:0001540]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; ATP-dependent protein binding [GO:0043008]; copper ion binding [GO:0005507]; cupric ion binding [GO:1903135]; cuprous ion binding [GO:1903136]; glycosaminoglycan binding [GO:0005539]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; molecular function activator activity [GO:0140677]; protease binding [GO:0002020]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; signaling receptor activity [GO:0038023]; transmembrane transporter binding [GO:0044325]; tubulin binding [GO:0015631]; type 5 metabotropic glutamate receptor binding [GO:0031802]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; Golgi apparatus [GO:0005794]; inclusion body [GO:0016234]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; terminal bouton [GO:0043195]; amyloid-beta binding [GO:0001540]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; ATP-dependent protein binding [GO:0043008]; copper ion binding [GO:0005507]; cupric ion binding [GO:1903135]; cuprous ion binding [GO:1903136]; glycosaminoglycan binding [GO:0005539]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; molecular function activator activity [GO:0140677]; protease binding [GO:0002020]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; signaling receptor activity [GO:0038023]; transmembrane transporter binding [GO:0044325]; tubulin binding [GO:0015631]; type 5 metabotropic glutamate receptor binding [GO:0031802]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell cycle [GO:0007049]; cellular response to amyloid-beta [GO:1904646]; cellular response to copper ion [GO:0071280]; cellular response to xenobiotic stimulus [GO:0071466]; dendritic spine maintenance [GO:0097062]; intracellular copper ion homeostasis [GO:0006878]; learning or memory [GO:0007611]; long-term memory [GO:0007616]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of dendritic spine maintenance [GO:1902951]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein processing [GO:0010955]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of type II interferon production [GO:0032689]; neuron projection maintenance [GO:1990535]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of protein tyrosine kinase activity [GO:0061098]; protein destabilization [GO:0031648]; protein homooligomerization [GO:0051260]; regulation of calcium ion import across plasma membrane [GO:1905664]; regulation of cell cycle [GO:0051726]; regulation of glutamate receptor signaling pathway [GO:1900449]; regulation of intracellular calcium activated chloride channel activity [GO:1902938]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of potassium ion transmembrane transport [GO:1901379]; response to amyloid-beta [GO:1904645]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19936054}. Golgi apparatus {ECO:0000250|UniProtKB:P04925}. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis. {ECO:0000269|PubMed:19936054}.
P04179	reviewed	SODM_HUMAN	Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)	SOD2	Homo sapiens (Human)	222	FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:10334867}.		acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0003069]; cellular response to ethanol [GO:0071361]; cellular response to oxidative stress [GO:0034599]; detection of oxygen [GO:0003032]; erythrophore differentiation [GO:0048773]; glutathione metabolic process [GO:0006749]; heart development [GO:0007507]; hemopoiesis [GO:0030097]; hydrogen peroxide biosynthetic process [GO:0050665]; intracellular oxygen homeostasis [GO:0032364]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; liver development [GO:0001889]; locomotory behavior [GO:0007626]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of membrane hyperpolarization [GO:1902631]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; neuron development [GO:0048666]; positive regulation of cell migration [GO:0030335]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [GO:1905932]; post-embryonic development [GO:0009791]; protein homotetramerization [GO:0051289]; regulation of blood pressure [GO:0008217]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of transcription by RNA polymerase II [GO:0006357]; release of cytochrome c from mitochondria [GO:0001836]; removal of superoxide radicals [GO:0019430]; respiratory electron transport chain [GO:0022904]; response to activity [GO:0014823]; response to axon injury [GO:0048678]; response to cadmium ion [GO:0046686]; response to electrical stimulus [GO:0051602]; response to gamma radiation [GO:0010332]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to isolation stress [GO:0035900]; response to L-ascorbic acid [GO:0033591]; response to lipopolysaccharide [GO:0032496]; response to magnetism [GO:0071000]; response to manganese ion [GO:0010042]; response to selenium ion [GO:0010269]; response to silicon dioxide [GO:0034021]; response to superoxide [GO:0000303]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; oxygen binding [GO:0019825]; superoxide dismutase activity [GO:0004784]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; oxygen binding [GO:0019825]; superoxide dismutase activity [GO:0004784]; acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0003069]; cellular response to ethanol [GO:0071361]; cellular response to oxidative stress [GO:0034599]; detection of oxygen [GO:0003032]; erythrophore differentiation [GO:0048773]; glutathione metabolic process [GO:0006749]; heart development [GO:0007507]; hemopoiesis [GO:0030097]; hydrogen peroxide biosynthetic process [GO:0050665]; intracellular oxygen homeostasis [GO:0032364]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; liver development [GO:0001889]; locomotory behavior [GO:0007626]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of membrane hyperpolarization [GO:1902631]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; neuron development [GO:0048666]; positive regulation of cell migration [GO:0030335]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [GO:1905932]; post-embryonic development [GO:0009791]; protein homotetramerization [GO:0051289]; regulation of blood pressure [GO:0008217]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of transcription by RNA polymerase II [GO:0006357]; release of cytochrome c from mitochondria [GO:0001836]; removal of superoxide radicals [GO:0019430]; respiratory electron transport chain [GO:0022904]; response to activity [GO:0014823]; response to axon injury [GO:0048678]; response to cadmium ion [GO:0046686]; response to electrical stimulus [GO:0051602]; response to gamma radiation [GO:0010332]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to isolation stress [GO:0035900]; response to L-ascorbic acid [GO:0033591]; response to lipopolysaccharide [GO:0032496]; response to magnetism [GO:0071000]; response to manganese ion [GO:0010042]; response to selenium ion [GO:0010269]; response to silicon dioxide [GO:0034021]; response to superoxide [GO:0000303]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P04180	reviewed	LCAT_HUMAN	Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (1-alkyl-2-acetylglycerophosphocholine esterase) (EC 3.1.1.47) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase)	LCAT	Homo sapiens (Human)	440	FUNCTION: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:8016111). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (PubMed:8016111). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (PubMed:24620755). {ECO:0000269|PubMed:10329423, ECO:0000269|PubMed:10722751, ECO:0000269|PubMed:12354767, ECO:0000269|PubMed:14636062, ECO:0000269|PubMed:19065001, ECO:0000269|PubMed:24620755, ECO:0000269|PubMed:26195816, ECO:0000269|PubMed:8016111, ECO:0000269|PubMed:8820107}.	MISCELLANEOUS: Levels of LCAT activity correlates inversely with leptin levels as well as with obesity for a wide range of BMI values.	cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; lipoprotein biosynthetic process [GO:0042158]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid metabolic process [GO:0006644]; regulation of high-density lipoprotein particle assembly [GO:0090107]; reverse cholesterol transport [GO:0043691]; very-low-density lipoprotein particle remodeling [GO:0034372]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; apolipoprotein A-I binding [GO:0034186]; phosphatidylcholine-sterol O-acyltransferase activity [GO:0004607]; platelet-activating factor acetyltransferase activity [GO:0047179]; sterol esterase activity [GO:0004771]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; apolipoprotein A-I binding [GO:0034186]; phosphatidylcholine-sterol O-acyltransferase activity [GO:0004607]; platelet-activating factor acetyltransferase activity [GO:0047179]; sterol esterase activity [GO:0004771]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; lipoprotein biosynthetic process [GO:0042158]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid metabolic process [GO:0006644]; regulation of high-density lipoprotein particle assembly [GO:0090107]; reverse cholesterol transport [GO:0043691]; very-low-density lipoprotein particle remodeling [GO:0034372]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10222237, ECO:0000269|PubMed:19065001, ECO:0000269|PubMed:3458198, ECO:0000269|PubMed:8016111, ECO:0000269|PubMed:8820107}. Note=Secreted into blood plasma (PubMed:3458198, PubMed:8820107, PubMed:10222237). Produced in astrocytes and secreted into cerebral spinal fluid (CSF) (PubMed:10222237). {ECO:0000269|PubMed:10222237, ECO:0000269|PubMed:3458198, ECO:0000269|PubMed:8820107}.
P04181	reviewed	OAT_HUMAN	Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form]	OAT	Homo sapiens (Human)	439	FUNCTION: Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate. {ECO:0000269|PubMed:1737786, ECO:0000269|PubMed:23076989}.		arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to proline via ornithine [GO:0010121]; L-proline biosynthetic process [GO:0055129]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]; ornithine(lysine) transaminase activity [GO:0050155]; ornithine-oxo-acid transaminase activity [GO:0004587]; pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; ornithine(lysine) transaminase activity [GO:0050155]; ornithine-oxo-acid transaminase activity [GO:0004587]; pyridoxal phosphate binding [GO:0030170]; arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to proline via ornithine [GO:0010121]; L-proline biosynthetic process [GO:0055129]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:23076989}.
P04183	reviewed	KITH_HUMAN	Thymidine kinase, cytosolic (EC 2.7.1.21)	TK1	Homo sapiens (Human)	234	FUNCTION: Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) (PubMed:22385435). {ECO:0000269|PubMed:22385435, ECO:0000269|PubMed:9575153, ECO:0000305|PubMed:17407781}.	MISCELLANEOUS: Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.	DNA synthesis involved in mitotic DNA replication [GO:1904860]; nucleobase-containing compound metabolic process [GO:0006139]; phosphorylation [GO:0016310]; protein homotetramerization [GO:0051289]; thymidine biosynthetic process [GO:0046105]; thymidine metabolic process [GO:0046104]	cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; thymidine kinase activity [GO:0004797]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; thymidine kinase activity [GO:0004797]; zinc ion binding [GO:0008270]; DNA synthesis involved in mitotic DNA replication [GO:1904860]; nucleobase-containing compound metabolic process [GO:0006139]; phosphorylation [GO:0016310]; protein homotetramerization [GO:0051289]; thymidine biosynthetic process [GO:0046105]; thymidine metabolic process [GO:0046104]	SUBCELLULAR LOCATION: Cytoplasm.
P04196	reviewed	HRG_HUMAN	Histidine-rich glycoprotein (Histidine-proline-rich glycoprotein) (HPRG)	HRG	Homo sapiens (Human)	525	FUNCTION: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis. {ECO:0000269|PubMed:11134179, ECO:0000269|PubMed:12235005, ECO:0000269|PubMed:14744774, ECO:0000269|PubMed:15220341, ECO:0000269|PubMed:15313924, ECO:0000269|PubMed:16436387, ECO:0000269|PubMed:16489009, ECO:0000269|PubMed:19285951, ECO:0000269|PubMed:19535045, ECO:0000269|PubMed:19712047, ECO:0000269|PubMed:19903770, ECO:0000269|PubMed:20573803, ECO:0000269|PubMed:21215706, ECO:0000269|PubMed:21304106}.		angiogenesis [GO:0001525]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chemotaxis [GO:0006935]; cytolysis by host of symbiont cells [GO:0051838]; defense response to fungus [GO:0050832]; fibrinolysis [GO:0042730]; heme transport [GO:0015886]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; platelet activation [GO:0030168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood vessel remodeling [GO:2000504]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of immune response to tumor cell [GO:0002839]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of blood coagulation [GO:0030193]; regulation of gene expression [GO:0010468]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of platelet activation [GO:0010543]; regulation of protein-containing complex assembly [GO:0043254]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endolysosome [GO:0036019]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; heme binding [GO:0020037]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; immunoglobulin binding [GO:0019865]; metal ion binding [GO:0046872]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]; zinc ion binding [GO:0008270]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endolysosome [GO:0036019]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; heme binding [GO:0020037]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; immunoglobulin binding [GO:0019865]; metal ion binding [GO:0046872]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]; zinc ion binding [GO:0008270]; angiogenesis [GO:0001525]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chemotaxis [GO:0006935]; cytolysis by host of symbiont cells [GO:0051838]; defense response to fungus [GO:0050832]; fibrinolysis [GO:0042730]; heme transport [GO:0015886]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; platelet activation [GO:0030168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood vessel remodeling [GO:2000504]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of immune response to tumor cell [GO:0002839]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of blood coagulation [GO:0030193]; regulation of gene expression [GO:0010468]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of platelet activation [GO:0010543]; regulation of protein-containing complex assembly [GO:0043254]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21215706}.
P04198	reviewed	MYCN_HUMAN	N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37)	MYCN BHLHE37 NMYC	Homo sapiens (Human)	464	FUNCTION: Positively regulates the transcription of MYCNOS in neuroblastoma cells. {ECO:0000269|PubMed:24391509}.		negative regulation of gene expression [GO:0010629]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of gene expression [GO:0010629]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P04201	reviewed	MAS_HUMAN	Proto-oncogene Mas	MAS1 MAS	Homo sapiens (Human)	325	FUNCTION: Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. {ECO:0000250, ECO:0000269|PubMed:15809376, ECO:0000269|PubMed:16611642}.		G protein-coupled receptor signaling pathway [GO:0007186]; hippocampus development [GO:0021766]; male gonad development [GO:0008584]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA replication [GO:0045740]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; protein kinase C signaling [GO:0070528]; regulation of inflammatory response [GO:0050727]; response to activity [GO:0014823]; response to gonadotropin [GO:0034698]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	angiotensin receptor activity [GO:0001595]; angiotensin type II receptor activity [GO:0004945]; G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; angiotensin receptor activity [GO:0001595]; angiotensin type II receptor activity [GO:0004945]; G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]; G protein-coupled receptor signaling pathway [GO:0007186]; hippocampus development [GO:0021766]; male gonad development [GO:0008584]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA replication [GO:0045740]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; protein kinase C signaling [GO:0070528]; regulation of inflammatory response [GO:0050727]; response to activity [GO:0014823]; response to gonadotropin [GO:0034698]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16611642}; Multi-pass membrane protein {ECO:0000269|PubMed:16611642}.
P04216	reviewed	THY1_HUMAN	Thy-1 membrane glycoprotein (CDw90) (Thy-1 antigen) (CD antigen CD90)	THY1	Homo sapiens (Human)	161	FUNCTION: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.		angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cytoskeleton organization [GO:0007010]; focal adhesion assembly [GO:0048041]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron projection regeneration [GO:0070571]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of T cell activation [GO:0050870]; receptor clustering [GO:0043113]; regulation of cell-matrix adhesion [GO:0001952]; regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000298]; retinal cone cell development [GO:0046549]; T cell receptor signaling pathway [GO:0050852]	apical plasma membrane [GO:0016324]; axolemma [GO:0030673]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; membrane raft [GO:0045121]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GPI anchor binding [GO:0034235]; GTPase activator activity [GO:0005096]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]	apical plasma membrane [GO:0016324]; axolemma [GO:0030673]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; membrane raft [GO:0045121]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; GPI anchor binding [GO:0034235]; GTPase activator activity [GO:0005096]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]; angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cytoskeleton organization [GO:0007010]; focal adhesion assembly [GO:0048041]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron projection regeneration [GO:0070571]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of T cell activation [GO:0050870]; receptor clustering [GO:0043113]; regulation of cell-matrix adhesion [GO:0001952]; regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000298]; retinal cone cell development [GO:0046549]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
P04217	reviewed	A1BG_HUMAN	Alpha-1B-glycoprotein (Alpha-1-B glycoprotein)	A1BG	Homo sapiens (Human)	495				blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774]		blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774]	SUBCELLULAR LOCATION: Secreted.
P04233	reviewed	HG2A_HUMAN	HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]	CD74 DHLAG	Homo sapiens (Human)	296	FUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250|UniProtKB:P04441, ECO:0000269|PubMed:32855215}.		antigen processing and presentation [GO:0019882]; antigen processing and presentation of endogenous antigen [GO:0019883]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; chaperone cofactor-dependent protein refolding [GO:0051085]; immunoglobulin mediated immune response [GO:0016064]; intracellular protein transport [GO:0006886]; macrophage migration inhibitory factor signaling pathway [GO:0035691]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of peptide secretion [GO:0002792]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of viral entry into host cell [GO:0046597]; negative thymic T cell selection [GO:0045060]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of kinase activity [GO:0033674]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of macrophage migration inhibitory factor signaling pathway [GO:2000448]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of type 2 immune response [GO:0002830]; positive regulation of viral entry into host cell [GO:0046598]; positive thymic T cell selection [GO:0045059]; prostaglandin biosynthetic process [GO:0001516]; protein stabilization [GO:0050821]; protein trimerization [GO:0070206]; protein-containing complex assembly [GO:0065003]; regulation of macrophage activation [GO:0043030]; response to type II interferon [GO:0034341]; T cell activation involved in immune response [GO:0002286]; T cell selection [GO:0045058]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; macrophage migration inhibitory factor receptor complex [GO:0035692]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; multivesicular body [GO:0005771]; NOS2-CD74 complex [GO:0035693]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; vacuole [GO:0005773]	amyloid-beta binding [GO:0001540]; CD4 receptor binding [GO:0042609]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; macrophage migration inhibitory factor binding [GO:0035718]; MHC class II protein binding [GO:0042289]; MHC class II protein binding, via antigen binding groove [GO:0042658]; MHC class II protein complex binding [GO:0023026]; nitric-oxide synthase binding [GO:0050998]; protein folding chaperone [GO:0044183]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; macrophage migration inhibitory factor receptor complex [GO:0035692]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; multivesicular body [GO:0005771]; NOS2-CD74 complex [GO:0035693]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; vacuole [GO:0005773]; amyloid-beta binding [GO:0001540]; CD4 receptor binding [GO:0042609]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; macrophage migration inhibitory factor binding [GO:0035718]; MHC class II protein binding [GO:0042289]; MHC class II protein binding, via antigen binding groove [GO:0042658]; MHC class II protein complex binding [GO:0023026]; nitric-oxide synthase binding [GO:0050998]; protein folding chaperone [GO:0044183]; antigen processing and presentation [GO:0019882]; antigen processing and presentation of endogenous antigen [GO:0019883]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; chaperone cofactor-dependent protein refolding [GO:0051085]; immunoglobulin mediated immune response [GO:0016064]; intracellular protein transport [GO:0006886]; macrophage migration inhibitory factor signaling pathway [GO:0035691]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of peptide secretion [GO:0002792]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of viral entry into host cell [GO:0046597]; negative thymic T cell selection [GO:0045060]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of kinase activity [GO:0033674]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of macrophage migration inhibitory factor signaling pathway [GO:2000448]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of type 2 immune response [GO:0002830]; positive regulation of viral entry into host cell [GO:0046598]; positive thymic T cell selection [GO:0045059]; prostaglandin biosynthetic process [GO:0001516]; protein stabilization [GO:0050821]; protein trimerization [GO:0070206]; protein-containing complex assembly [GO:0065003]; regulation of macrophage activation [GO:0043030]; response to type II interferon [GO:0034341]; T cell activation involved in immune response [GO:0002286]; T cell selection [GO:0045058]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313}. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.; SUBCELLULAR LOCATION: [Isoform p41]: Late endosome {ECO:0000250|UniProtKB:P04441}. Lysosome {ECO:0000250|UniProtKB:P04441}.
P04234	reviewed	CD3D_HUMAN	T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)	CD3D T3D	Homo sapiens (Human)	171	FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456). {ECO:0000269|PubMed:12215456, ECO:0000269|PubMed:12507424, ECO:0000269|PubMed:2470098}.		adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; cell surface receptor signaling pathway [GO:0007166]; positive thymic T cell selection [GO:0045059]; T cell receptor signaling pathway [GO:0050852]	alpha-beta T cell receptor complex [GO:0042105]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]	alpha-beta T cell receptor complex [GO:0042105]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; cell surface receptor signaling pathway [GO:0007166]; positive thymic T cell selection [GO:0045059]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P04259	reviewed	K2C6B_HUMAN	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK-6B) (Keratin-6B) (K6B) (Type-II keratin Kb10)	KRT6B K6B KRTL1	Homo sapiens (Human)	564		MISCELLANEOUS: There are at least six isoforms of human type II keratin-6 (K6).; MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	ectoderm development [GO:0007398]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]	structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280]; ectoderm development [GO:0007398]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
P04264	reviewed	K2C1_HUMAN	Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)	KRT1 KRTA	Homo sapiens (Human)	644	FUNCTION: May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. {ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:21544310}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	complement activation, lectin pathway [GO:0001867]; establishment of skin barrier [GO:0061436]; fibrinolysis [GO:0042730]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; negative regulation of inflammatory response [GO:0050728]; peptide cross-linking [GO:0018149]; protein heterotetramerization [GO:0051290]; regulation of angiogenesis [GO:0045765]; response to oxidative stress [GO:0006979]; retina homeostasis [GO:0001895]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634]	carbohydrate binding [GO:0030246]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; structural constituent of skin epidermis [GO:0030280]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634]; carbohydrate binding [GO:0030246]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; structural constituent of skin epidermis [GO:0030280]; complement activation, lectin pathway [GO:0001867]; establishment of skin barrier [GO:0061436]; fibrinolysis [GO:0042730]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; negative regulation of inflammatory response [GO:0050728]; peptide cross-linking [GO:0018149]; protein heterotetramerization [GO:0051290]; regulation of angiogenesis [GO:0045765]; response to oxidative stress [GO:0006979]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17956333}. Cytoplasm {ECO:0000269|PubMed:32179842}.
P04271	reviewed	S100B_HUMAN	Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)	S100B	Homo sapiens (Human)	92	FUNCTION: Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:6487634, PubMed:20950652). Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (PubMed:6487634, PubMed:20950652). Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity). Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (By similarity). Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (By similarity). Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity). Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (PubMed:20351179). May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (PubMed:22399290). {ECO:0000250|UniProtKB:P02638, ECO:0000250|UniProtKB:P04631, ECO:0000250|UniProtKB:P50114, ECO:0000269|PubMed:20351179, ECO:0000269|PubMed:20950652, ECO:0000269|PubMed:22399290, ECO:0000269|PubMed:6487634}.		adaptive thermogenesis [GO:1990845]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; learning or memory [GO:0007611]; memory [GO:0007613]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of neuron differentiation [GO:0045666]; regulation of neuronal synaptic plasticity [GO:0048168]; sympathetic neuron projection extension [GO:0097490]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ruffle [GO:0001726]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; ion binding [GO:0043167]; protein homodimerization activity [GO:0042803]; RAGE receptor binding [GO:0050786]; S100 protein binding [GO:0044548]; tau protein binding [GO:0048156]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ruffle [GO:0001726]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; ion binding [GO:0043167]; protein homodimerization activity [GO:0042803]; RAGE receptor binding [GO:0050786]; S100 protein binding [GO:0044548]; tau protein binding [GO:0048156]; zinc ion binding [GO:0008270]; adaptive thermogenesis [GO:1990845]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; learning or memory [GO:0007611]; memory [GO:0007613]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of neuron differentiation [GO:0045666]; regulation of neuronal synaptic plasticity [GO:0048168]; sympathetic neuron projection extension [GO:0097490]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9925766}. Nucleus {ECO:0000269|PubMed:9925766}. Secreted {ECO:0000250|UniProtKB:P50114}. Note=Secretion into the medium is promoted by interaction with isoform CLSTN3beta of CLSTN3. {ECO:0000250|UniProtKB:P50114}.
P04275	reviewed	VWF_HUMAN	von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)]	VWF F8VWF	Homo sapiens (Human)	2813	FUNCTION: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.		blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; hemostasis [GO:0007599]; platelet activation [GO:0030168]; positive regulation of intracellular signal transduction [GO:1902533]; response to wounding [GO:0009611]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; Weibel-Palade body [GO:0033093]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; immunoglobulin binding [GO:0019865]; integrin binding [GO:0005178]; protease binding [GO:0002020]; protein-folding chaperone binding [GO:0051087]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; Weibel-Palade body [GO:0033093]; collagen binding [GO:0005518]; identical protein binding [GO:0042802]; immunoglobulin binding [GO:0019865]; integrin binding [GO:0005178]; protease binding [GO:0002020]; protein-folding chaperone binding [GO:0051087]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; hemostasis [GO:0007599]; platelet activation [GO:0030168]; positive regulation of intracellular signal transduction [GO:1902533]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10961880}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10961880}. Note=Localized to storage granules.
P04278	reviewed	SHBG_HUMAN	Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estradiol-binding globulin) (TeBG) (Testosterone-estrogen-binding globulin)	SHBG	Homo sapiens (Human)	402	FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.			extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	androgen binding [GO:0005497]; steroid binding [GO:0005496]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; androgen binding [GO:0005497]; steroid binding [GO:0005496]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. {ECO:0000250}.
P04279	reviewed	SEMG1_HUMAN	Semenogelin-1 (Cancer/testis antigen 103) (Semenogelin I) (SGI) [Cleaved into: Alpha-inhibin-92; Alpha-inhibin-31; Seminal basic protein]	SEMG1 SEMG	Homo sapiens (Human)	462	FUNCTION: Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. {ECO:0000269|PubMed:19889947}.; FUNCTION: Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. {ECO:0000269|PubMed:19889947}.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; coagulation [GO:0050817]; insemination [GO:0007320]; killing of cells of another organism [GO:0031640]; negative regulation of calcium ion import [GO:0090281]; negative regulation of flagellated sperm motility [GO:1901318]; positive regulation of serine-type endopeptidase activity [GO:1900005]; sperm capacitation [GO:0048240]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; zinc ion binding [GO:0008270]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; coagulation [GO:0050817]; insemination [GO:0007320]; killing of cells of another organism [GO:0031640]; negative regulation of calcium ion import [GO:0090281]; negative regulation of flagellated sperm motility [GO:1901318]; positive regulation of serine-type endopeptidase activity [GO:1900005]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Secreted.
P04280	reviewed	PRP1_HUMAN	Basic salivary proline-rich protein 1 (Salivary proline-rich protein) [Cleaved into: Proline-rich peptide II-2; Basic peptide IB-6; Peptide P-H]	PRB1	Homo sapiens (Human)	392				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3521730}.
P04350	reviewed	TBB4A_HUMAN	Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain)	TUBB4A TUBB4 TUBB5	Homo sapiens (Human)	444	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; negative regulation of microtubule polymerization [GO:0031115]	axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; internode region of axon [GO:0033269]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]	axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; internode region of axon [GO:0033269]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; negative regulation of microtubule polymerization [GO:0031115]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P04406	reviewed	G3P_HUMAN	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-)	GAPDH GAPD CDABP0047 OK/SW-cl.12	Homo sapiens (Human)	335	FUNCTION: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:3170585, PubMed:11724794). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:3170585, PubMed:11724794). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to type II interferon [GO:0071346]; defense response to fungus [GO:0050832]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of translation [GO:0017148]; neuron apoptotic process [GO:0051402]; peptidyl-cysteine S-trans-nitrosylation [GO:0035606]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of type I interferon production [GO:0032481]; protein stabilization [GO:0050821]; regulation of macroautophagy [GO:0016241]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GAIT complex [GO:0097452]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; vesicle [GO:0031982]	aspartic-type endopeptidase inhibitor activity [GO:0019828]; disordered domain specific binding [GO:0097718]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; peptidyl-cysteine S-nitrosylase activity [GO:0035605]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GAIT complex [GO:0097452]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; vesicle [GO:0031982]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; disordered domain specific binding [GO:0097718]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; peptidyl-cysteine S-nitrosylase activity [GO:0035605]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to type II interferon [GO:0071346]; defense response to fungus [GO:0050832]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of translation [GO:0017148]; neuron apoptotic process [GO:0051402]; peptidyl-cysteine S-trans-nitrosylation [GO:0035606]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of type I interferon production [GO:0032481]; protein stabilization [GO:0050821]; regulation of macroautophagy [GO:0016241]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12829261}. Nucleus {ECO:0000250|UniProtKB:P04797}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12829261}. Membrane {ECO:0000269|PubMed:12829261}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P04797}. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions (PubMed:12829261). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:12829261}.
P04424	reviewed	ARLY_HUMAN	Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase)	ASL	Homo sapiens (Human)	464	FUNCTION: Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues (PubMed:11747433, PubMed:11747432, PubMed:9045711, PubMed:22081021, PubMed:2263616). Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway (PubMed:22081021). {ECO:0000269|PubMed:11747432, ECO:0000269|PubMed:11747433, ECO:0000269|PubMed:22081021, ECO:0000269|PubMed:9045711}.		ammonia assimilation cycle [GO:0019676]; arginine biosynthetic process [GO:0006526]; arginine biosynthetic process via ornithine [GO:0042450]; arginine metabolic process [GO:0006525]; locomotory behavior [GO:0007626]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; post-embryonic development [GO:0009791]; urea cycle [GO:0000050]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	argininosuccinate lyase activity [GO:0004056]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; argininosuccinate lyase activity [GO:0004056]; identical protein binding [GO:0042802]; ammonia assimilation cycle [GO:0019676]; arginine biosynthetic process [GO:0006526]; arginine biosynthetic process via ornithine [GO:0042450]; arginine metabolic process [GO:0006525]; locomotory behavior [GO:0007626]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; post-embryonic development [GO:0009791]; urea cycle [GO:0000050]	
P04439	reviewed	HLAA_HUMAN	HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)	HLA-A HLAA	Homo sapiens (Human)	365	FUNCTION: Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:2456340, PubMed:2784196, PubMed:1402688, PubMed:7504010, PubMed:9862734, PubMed:10449296, PubMed:12138174, PubMed:12393434, PubMed:15893615, PubMed:17189421, PubMed:19543285, PubMed:21498667, PubMed:24192765, PubMed:7694806, PubMed:24395804, PubMed:28250417). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728, PubMed:7679507). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17189421, PubMed:20364150, PubMed:17079320, PubMed:26929325, PubMed:27049119). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:7504010, PubMed:9862734). {ECO:0000269|PubMed:10449296, ECO:0000269|PubMed:12138174, ECO:0000269|PubMed:12393434, ECO:0000269|PubMed:12796775, ECO:0000269|PubMed:1402688, ECO:0000269|PubMed:15893615, ECO:0000269|PubMed:17079320, ECO:0000269|PubMed:17189421, ECO:0000269|PubMed:18275829, ECO:0000269|PubMed:19542454, ECO:0000269|PubMed:19543285, ECO:0000269|PubMed:20364150, ECO:0000269|PubMed:21498667, ECO:0000269|PubMed:24192765, ECO:0000269|PubMed:24395804, ECO:0000269|PubMed:2456340, ECO:0000269|PubMed:25880248, ECO:0000269|PubMed:26929325, ECO:0000269|PubMed:27049119, ECO:0000269|PubMed:2784196, ECO:0000269|PubMed:28250417, ECO:0000269|PubMed:7504010, ECO:0000269|PubMed:7506728, ECO:0000269|PubMed:7679507, ECO:0000269|PubMed:7694806, ECO:0000269|PubMed:9862734}.; FUNCTION: Allele A*01:01: Presents a restricted peptide repertoire including viral epitopes derived from IAV NP/nucleoprotein (CTELKLSDY), IAV PB1/polymerase basic protein 1 (VSDGGPNLY), HAdV-11 capsid L3/hexon protein (LTDLGQNLLY), SARS-CoV-2 3a/ORF3a (FTSDYYQLY) as well as tumor peptide antigens including MAGE1 (EADPTGHSY), MAGEA3 (EVDPIGHLY) and WT1 (TSEKRPFMCAY), all having in common a canonical motif with a negatively charged Asp or Glu residue at position 3 and a Tyr anchor residue at the C-terminus (PubMed:1402688, PubMed:7504010, PubMed:17189421, PubMed:20364150, PubMed:25880248, PubMed:30530481, PubMed:19177349, PubMed:24395804, PubMed:26758806, PubMed:32887977). A number of HLA-A*01:01-restricted peptides carry a post-translational modification with oxidation and N-terminal acetylation being the most frequent (PubMed:25880248). Fails to present highly immunogenic peptides from the EBV latent antigens (PubMed:18779413). {ECO:0000269|PubMed:1402688, ECO:0000269|PubMed:17189421, ECO:0000269|PubMed:18779413, ECO:0000269|PubMed:19177349, ECO:0000269|PubMed:20364150, ECO:0000269|PubMed:24395804, ECO:0000269|PubMed:25880248, ECO:0000269|PubMed:26758806, ECO:0000269|PubMed:30530481, ECO:0000269|PubMed:7504010}.; FUNCTION: Allele A*02:01: A major allele in human populations, presents immunodominant viral epitopes derived from IAV M/matrix protein 1 (GILGFVFTL), HIV-1 env (TLTSCNTSV), HIV-1 gag-pol (ILKEPVHGV), HTLV-1 Tax (LLFGYPVYV), HBV C/core antigen (FLPSDFFPS), HCMV UL83/pp65 (NLVPMVATV) as well as tumor peptide antigens including MAGEA4 (GVYDGREHTV), WT1 (RMFPNAPYL) and CTAG1A/NY-ESO-1 (SLLMWITQC), all having in common hydrophobic amino acids at position 2 and at the C-terminal anchors. {ECO:0000269|PubMed:11502003, ECO:0000269|PubMed:12138174, ECO:0000269|PubMed:12796775, ECO:0000269|PubMed:17079320, ECO:0000269|PubMed:18275829, ECO:0000269|PubMed:19542454, ECO:0000269|PubMed:20619457, ECO:0000269|PubMed:22245737, ECO:0000269|PubMed:26929325, ECO:0000269|PubMed:2784196, ECO:0000269|PubMed:28250417, ECO:0000269|PubMed:7694806, ECO:0000269|PubMed:7935798, ECO:0000269|PubMed:8630735, ECO:0000269|PubMed:8805302, ECO:0000269|PubMed:8906788, ECO:0000269|PubMed:9177355}.; FUNCTION: Allele A*03:01: Presents viral epitopes derived from IAV NP (ILRGSVAHK), HIV-1 nef (QVPLRPMTYK), HIV-1 gag-pol (AIFQSSMTK), SARS-CoV-2 N/nucleoprotein (KTFPPTEPK) as well as tumor peptide antigens including PMEL (LIYRRRLMK), NODAL (HAYIQSLLK), TRP-2 (RMYNMVPFF), all having in common hydrophobic amino acids at position 2 and Lys or Arg anchor residues at the C-terminus (PubMed:7504010, PubMed:7679507, PubMed:9862734, PubMed:19543285, PubMed:21943705, PubMed:2456340, PubMed:32887977). May also display spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119). {ECO:0000269|PubMed:19543285, ECO:0000269|PubMed:21943705, ECO:0000269|PubMed:2456340, ECO:0000269|PubMed:27049119, ECO:0000269|PubMed:7504010, ECO:0000269|PubMed:7679507, ECO:0000269|PubMed:9862734}.; FUNCTION: Allele A*11:01: Presents several immunodominant epitopes derived from HIV-1 gag-pol and HHV-4 EBNA4, containing the peptide motif with Val, Ile, Thr, Leu, Tyr or Phe at position 2 and Lys anchor residue at the C-terminus. Important in the control of HIV-1, EBV and HBV infections (PubMed:10449296). Presents an immunodominant epitope derived from SARS-CoV-2 N/nucleoprotein (KTFPPTEPK) (PubMed:32887977). {ECO:0000269|PubMed:10449296, ECO:0000269|PubMed:32887977}.; FUNCTION: Allele A*23:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response. {ECO:0000269|PubMed:17182537}.; FUNCTION: Allele A*24:02: Presents viral epitopes derived from HIV-1 nef (RYPLTFGWCF), EBV lytic- and latent-cycle antigens BRLF1 (TYPVLEEMF), BMLF1 (DYNFVKQLF) and LMP2 (IYVLVMLVL), SARS-CoV nucleocapsid/N (QFKDNVILL), as well as tumor peptide antigens including PRAME (LYVDSLFFL), all sharing a common signature motif, namely an aromatic residue Tyr or Phe at position 2 and a nonhydrophobic anchor residue Phe, Leu or Iso at the C-terminus (PubMed:9047241, PubMed:12393434, PubMed:24192765, PubMed:20844028). Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response (PubMed:17182537, PubMed:18502829). {ECO:0000269|PubMed:12393434, ECO:0000269|PubMed:17182537, ECO:0000269|PubMed:18502829, ECO:0000269|PubMed:20844028, ECO:0000269|PubMed:24192765, ECO:0000269|PubMed:9047241}.; FUNCTION: Allele A*26:01: Presents several epitopes derived from HIV-1 gag-pol (EVIPMFSAL, ETKLGKAGY) and env (LVSDGGPNLY), carrying as anchor residues preferentially Glu at position 1, Val or Thr at position 2 and Tyr at the C-terminus. {ECO:0000269|PubMed:15893615}.; FUNCTION: Allele A*29:02: Presents peptides having a common motif, namely a Glu residue at position 2 and Tyr or Leu anchor residues at the C-terminus. {ECO:0000269|PubMed:8622959}.; FUNCTION: Allele A*32:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response. {ECO:0000269|PubMed:17182537}.; FUNCTION: Allele A*68:01: Presents viral epitopes derived from IAV NP (KTGGPIYKR) and HIV-1 tat (ITKGLGISYGR), having a common signature motif namely, Val or Thr at position 2 and positively charged residues Arg or Lys at the C-terminal anchor. {ECO:0000269|PubMed:1448153, ECO:0000269|PubMed:1448154, ECO:0000269|PubMed:2784196}.; FUNCTION: Allele A*74:01: Presents immunodominant HIV-1 epitopes derived from gag-pol (GQMVHQAISPR, QIYPGIKVR) and rev (RQIHSISER), carrying an aliphatic residue at position 2 and Arg anchor residue at the C-terminus. May contribute to viral load control in chronic HIV-1 infection. {ECO:0000269|PubMed:21498667}.		antibacterial humoral response [GO:0019731]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; CD8-positive, alpha-beta T cell activation [GO:0036037]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of CD8-positive, alpha-beta T cell activation [GO:2001187]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of memory T cell activation [GO:2000568]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of type II interferon production [GO:0032729]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; T cell mediated cytotoxicity [GO:0001913]; T cell mediated cytotoxicity directed against tumor cell target [GO:0002419]; T cell receptor signaling pathway [GO:0050852]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	beta-2-microglobulin binding [GO:0030881]; CD8 receptor binding [GO:0042610]; peptide antigen binding [GO:0042605]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608]; TAP binding [GO:0046977]; TAP complex binding [GO:0062061]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; beta-2-microglobulin binding [GO:0030881]; CD8 receptor binding [GO:0042610]; peptide antigen binding [GO:0042605]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608]; TAP binding [GO:0046977]; TAP complex binding [GO:0062061]; antibacterial humoral response [GO:0019731]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; CD8-positive, alpha-beta T cell activation [GO:0036037]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of CD8-positive, alpha-beta T cell activation [GO:2001187]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of memory T cell activation [GO:2000568]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of type II interferon production [GO:0032729]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; T cell mediated cytotoxicity [GO:0001913]; T cell mediated cytotoxicity directed against tumor cell target [GO:0002419]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21263072, ECO:0000269|PubMed:25880248, ECO:0000269|PubMed:8805302}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:8805302}; Single-pass type I membrane protein {ECO:0000255}.
P04440	reviewed	DPB1_HUMAN	HLA class II histocompatibility antigen, DP beta 1 chain (HLA class II histocompatibility antigen, DP(W4) beta chain) (MHC class II antigen DPB1)	HLA-DPB1 HLA-DP1B	Homo sapiens (Human)	258	FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]; T cell receptor signaling pathway [GO:0050852]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]	MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
P04553	reviewed	HSP1_HUMAN	Sperm protamine P1 (Cysteine-rich protamine)	PRM1	Homo sapiens (Human)	51	FUNCTION: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.		chromosome condensation [GO:0030261]; chromosome organization [GO:0051276]; sperm DNA condensation [GO:0035092]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]	DNA binding [GO:0003677]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; DNA binding [GO:0003677]; chromosome condensation [GO:0030261]; chromosome organization [GO:0051276]; sperm DNA condensation [GO:0035092]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P04554	reviewed	PRM2_HUMAN	Protamine-2 (Sperm histone P2) (Sperm protamine P2) [Cleaved into: Basic nuclear protein HPI1; Basic nuclear protein HPI2; Basic nuclear protein HPS1; Basic nuclear protein HPS2; Sperm histone HP4 (Sperm protamine P4); Sperm histone HP2 (Sperm protamine P2) (P2'); Sperm histone HP3 (P2'') (Sperm protamine P3)]	PRM2	Homo sapiens (Human)	102	FUNCTION: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. {ECO:0000250|UniProtKB:P07978}.		chromosome condensation [GO:0030261]; chromosome organization [GO:0051276]; nucleus organization [GO:0006997]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	cadmium ion binding [GO:0046870]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; cadmium ion binding [GO:0046870]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; chromosome condensation [GO:0030261]; chromosome organization [GO:0051276]; nucleus organization [GO:0006997]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P07978}. Chromosome {ECO:0000250|UniProtKB:P07978}.
P04626	reviewed	ERBB2_HUMAN	Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)	ERBB2 HER2 MLN19 NEU NGL	Homo sapiens (Human)	1255	FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at Met-611 of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation at Met-687 of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 1. {ECO:0000305}.	cell surface receptor signaling pathway [GO:0007166]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; enzyme-linked receptor protein signaling pathway [GO:0007167]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERBB2-ERBB4 signaling pathway [GO:0038135]; heart development [GO:0007507]; immature T cell proliferation in thymus [GO:0033080]; intracellular signal transduction [GO:0035556]; motor neuron axon guidance [GO:0008045]; myelination [GO:0042552]; negative regulation of apoptotic process [GO:0043066]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; neurogenesis [GO:0022008]; neuromuscular junction development [GO:0007528]; neuron differentiation [GO:0030182]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine phosphorylation [GO:0018108]; peripheral nervous system development [GO:0007422]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of translation [GO:0045727]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of angiogenesis [GO:0045765]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of microtubule-based process [GO:0032886]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; wound healing [GO:0042060]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; ERBB3:ERBB2 complex [GO:0038143]; membrane [GO:0016020]; myelin sheath [GO:0043209]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]	ATP binding [GO:0005524]; ErbB-3 class receptor binding [GO:0043125]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein tyrosine kinase activity [GO:0004713]; RNA polymerase I core binding [GO:0001042]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; ERBB3:ERBB2 complex [GO:0038143]; membrane [GO:0016020]; myelin sheath [GO:0043209]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; ATP binding [GO:0005524]; ErbB-3 class receptor binding [GO:0043125]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein tyrosine kinase activity [GO:0004713]; RNA polymerase I core binding [GO:0001042]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; enzyme-linked receptor protein signaling pathway [GO:0007167]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERBB2-ERBB4 signaling pathway [GO:0038135]; heart development [GO:0007507]; immature T cell proliferation in thymus [GO:0033080]; intracellular signal transduction [GO:0035556]; motor neuron axon guidance [GO:0008045]; myelination [GO:0042552]; negative regulation of apoptotic process [GO:0043066]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; neurogenesis [GO:0022008]; neuromuscular junction development [GO:0007528]; neuron differentiation [GO:0030182]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine phosphorylation [GO:0018108]; peripheral nervous system development [GO:0007422]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of translation [GO:0045727]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of angiogenesis [GO:0045765]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of microtubule-based process [GO:0032886]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32381043}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:34380438}; Single-pass type I membrane protein {ECO:0000255}. Note=Internalized from the cell membrane in response to EGF stimulation. {ECO:0000269|PubMed:32381043}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:31138794, ECO:0000269|PubMed:33497358}; Single-pass type I membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:31138794}. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). {ECO:0000269|PubMed:31138794}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.
P04628	reviewed	WNT1_HUMAN	Proto-oncogene Wnt-1 (Proto-oncogene Int-1 homolog)	WNT1 INT1	Homo sapiens (Human)	370	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646). {ECO:0000250|UniProtKB:P04426, ECO:0000269|PubMed:23499309, ECO:0000269|PubMed:23656646, ECO:0000269|PubMed:26902720, ECO:0000269|PubMed:28528193, ECO:0000305}.		animal organ regeneration [GO:0031100]; astrocyte-dopaminergic neuron signaling [GO:0036520]; bone development [GO:0060348]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954]; cell fate commitment [GO:0045165]; cell proliferation in midbrain [GO:0033278]; cell-cell signaling [GO:0007267]; cellular response to peptide hormone stimulus [GO:0071375]; central nervous system morphogenesis [GO:0021551]; cerebellum formation [GO:0021588]; diencephalon development [GO:0021536]; embryonic axis specification [GO:0000578]; embryonic brain development [GO:1990403]; fat cell differentiation [GO:0045444]; forebrain anterior/posterior pattern specification [GO:0021797]; hematopoietic stem cell proliferation [GO:0071425]; hepatocyte differentiation [GO:0070365]; inner ear morphogenesis [GO:0042472]; midbrain development [GO:0030901]; midbrain-hindbrain boundary maturation during brain development [GO:0022004]; myoblast fusion [GO:0007520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of cellular senescence [GO:2000773]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neuron differentiation [GO:0030182]; neuron fate determination [GO:0048664]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to wounding [GO:0009611]; signal transduction in response to DNA damage [GO:0042770]; Spemann organizer formation [GO:0060061]; spinal cord association neuron differentiation [GO:0021527]; T cell differentiation in thymus [GO:0033077]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; morphogen activity [GO:0016015]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; morphogen activity [GO:0016015]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; animal organ regeneration [GO:0031100]; astrocyte-dopaminergic neuron signaling [GO:0036520]; bone development [GO:0060348]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954]; cell fate commitment [GO:0045165]; cell proliferation in midbrain [GO:0033278]; cell-cell signaling [GO:0007267]; cellular response to peptide hormone stimulus [GO:0071375]; central nervous system morphogenesis [GO:0021551]; cerebellum formation [GO:0021588]; diencephalon development [GO:0021536]; embryonic axis specification [GO:0000578]; embryonic brain development [GO:1990403]; fat cell differentiation [GO:0045444]; forebrain anterior/posterior pattern specification [GO:0021797]; hematopoietic stem cell proliferation [GO:0071425]; hepatocyte differentiation [GO:0070365]; inner ear morphogenesis [GO:0042472]; midbrain development [GO:0030901]; midbrain-hindbrain boundary maturation during brain development [GO:0022004]; myoblast fusion [GO:0007520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of cellular senescence [GO:2000773]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neuron differentiation [GO:0030182]; neuron fate determination [GO:0048664]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to wounding [GO:0009611]; signal transduction in response to DNA damage [GO:0042770]; Spemann organizer formation [GO:0060061]; spinal cord association neuron differentiation [GO:0021527]; T cell differentiation in thymus [GO:0033077]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
P04629	reviewed	NTRK1_HUMAN	High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)	NTRK1 MTC TRK TRKA	Homo sapiens (Human)	796	FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. {ECO:0000250|UniProtKB:P35739, ECO:0000250|UniProtKB:Q3UFB7, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:1281417, ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:17196528, ECO:0000269|PubMed:1849459, ECO:0000269|PubMed:1850821, ECO:0000269|PubMed:22649032, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27676246, ECO:0000269|PubMed:8155326, ECO:0000269|PubMed:8325889}.; FUNCTION: [Isoform TrkA-III]: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. {ECO:0000269|PubMed:15488758}.	MISCELLANEOUS: Trk also stands for tropomyosin-related kinase since it was first isolated as an oncogenic protein which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1.; MISCELLANEOUS: [Isoform TrkA-II]: Major isoform.; MISCELLANEOUS: [Isoform TrkA-I]: Has enhanced responsiveness to NTF3 neurotrophin. {ECO:0000305}.; MISCELLANEOUS: [Isoform TrkA-III]: Constitutively active. Does not bind NGF and does not interact with GRB2 and FRS2. {ECO:0000305}.	axon guidance [GO:0007411]; axonogenesis involved in innervation [GO:0060385]; B cell differentiation [GO:0030183]; behavioral response to formalin induced pain [GO:0061368]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to nicotine [GO:0071316]; circadian rhythm [GO:0007623]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; learning or memory [GO:0007611]; mechanoreceptor differentiation [GO:0042490]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; nerve growth factor signaling pathway [GO:0038180]; neuron apoptotic process [GO:0051402]; neuron development [GO:0048666]; neuron projection development [GO:0031175]; neurotrophin TRK receptor signaling pathway [GO:0048011]; olfactory nerve development [GO:0021553]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; programmed cell death involved in cell development [GO:0010623]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; response to axon injury [GO:0048678]; response to electrical stimulus [GO:0051602]; response to hydrostatic pressure [GO:0051599]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; Sertoli cell development [GO:0060009]; sympathetic nervous system development [GO:0048485]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; recycling endosome membrane [GO:0055038]	ATP binding [GO:0005524]; GPI-linked ephrin receptor activity [GO:0005004]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; nerve growth factor binding [GO:0048406]; nerve growth factor receptor activity [GO:0010465]; neurotrophin binding [GO:0043121]; neurotrophin p75 receptor binding [GO:0005166]; neurotrophin receptor activity [GO:0005030]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; recycling endosome membrane [GO:0055038]; ATP binding [GO:0005524]; GPI-linked ephrin receptor activity [GO:0005004]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; nerve growth factor binding [GO:0048406]; nerve growth factor receptor activity [GO:0010465]; neurotrophin binding [GO:0043121]; neurotrophin p75 receptor binding [GO:0005166]; neurotrophin receptor activity [GO:0005030]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; axon guidance [GO:0007411]; axonogenesis involved in innervation [GO:0060385]; B cell differentiation [GO:0030183]; behavioral response to formalin induced pain [GO:0061368]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to nicotine [GO:0071316]; circadian rhythm [GO:0007623]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; learning or memory [GO:0007611]; mechanoreceptor differentiation [GO:0042490]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; nerve growth factor signaling pathway [GO:0038180]; neuron apoptotic process [GO:0051402]; neuron development [GO:0048666]; neuron projection development [GO:0031175]; neurotrophin TRK receptor signaling pathway [GO:0048011]; olfactory nerve development [GO:0021553]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; programmed cell death involved in cell development [GO:0010623]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; response to axon injury [GO:0048678]; response to electrical stimulus [GO:0051602]; response to hydrostatic pressure [GO:0051599]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; Sertoli cell development [GO:0060009]; sympathetic nervous system development [GO:0048485]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1281417, ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:17196528, ECO:0000269|PubMed:27676246, ECO:0000269|PubMed:2927393}; Single-pass type I membrane protein {ECO:0000269|PubMed:1281417, ECO:0000269|PubMed:15488758}. Early endosome membrane {ECO:0000250|UniProtKB:P35739}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P35739}. Late endosome membrane {ECO:0000250|UniProtKB:P35739}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P35739}. Recycling endosome membrane {ECO:0000250|UniProtKB:P35739}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P35739}. Note=Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes. {ECO:0000250|UniProtKB:P35739, ECO:0000269|PubMed:1281417}.
P04632	reviewed	CPNS1_HUMAN	Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit)	CAPNS1 CAPN4 CAPNS	Homo sapiens (Human)	268	FUNCTION: Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:O88456}.		positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; regulation of macroautophagy [GO:0016241]	calpain complex [GO:0110158]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	calpain complex [GO:0110158]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; regulation of macroautophagy [GO:0016241]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}.
P04637	reviewed	P53_HUMAN	Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)	TP53 P53	Homo sapiens (Human)	393	FUNCTION: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:9840937, PubMed:24652652). Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:9840937, PubMed:24652652). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:9840937}.	MISCELLANEOUS: [Isoform 2]: Expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Produced by alternative promoter usage and alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Produced by alternative promoter usage and alternative splicing. {ECO:0000305}.	autophagy [GO:0006914]; B cell lineage commitment [GO:0002326]; bone marrow development [GO:0048539]; cardiac muscle cell apoptotic process [GO:0010659]; cardiac septum morphogenesis [GO:0060411]; cellular response to actinomycin D [GO:0072717]; cellular response to gamma radiation [GO:0071480]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; cellular response to UV-C [GO:0071494]; cellular response to xenobiotic stimulus [GO:0071466]; cellular senescence [GO:0090398]; cerebellum development [GO:0021549]; chromosome organization [GO:0051276]; circadian behavior [GO:0048512]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; embryonic organ development [GO:0048568]; entrainment of circadian clock by photoperiod [GO:0043153]; ER overload response [GO:0006983]; fibroblast proliferation [GO:0048144]; gastrulation [GO:0007369]; glial cell proliferation [GO:0014009]; glucose catabolic process to lactate via pyruvate [GO:0019661]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell differentiation [GO:0060218]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; mitochondrial DNA repair [GO:0043504]; mitophagy [GO:0000423]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA transcription [GO:0009299]; multicellular organism growth [GO:0035264]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G1 to G0 transition [GO:1903451]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of glucose catabolic process to lactate via pyruvate [GO:1904024]; negative regulation of helicase activity [GO:0051097]; negative regulation of miRNA processing [GO:1903799]; negative regulation of mitophagy [GO:1901525]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of pentose-phosphate shunt [GO:1905856]; negative regulation of proteolysis [GO:0045861]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of telomerase activity [GO:0051974]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuroblast proliferation [GO:0007405]; neuron apoptotic process [GO:0051402]; nucleotide-excision repair [GO:0006289]; oligodendrocyte apoptotic process [GO:0097252]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cellular senescence [GO:2000774]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; protein-containing complex assembly [GO:0065003]; Ras protein signal transduction [GO:0007265]; reactive oxygen species metabolic process [GO:0072593]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of DNA-templated transcription [GO:0006355]; regulation of fibroblast apoptotic process [GO:2000269]; regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902253]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]; regulation of tissue remodeling [GO:0034103]; regulation of transcription by RNA polymerase II [GO:0006357]; release of cytochrome c from mitochondria [GO:0001836]; replicative senescence [GO:0090399]; response to antibiotic [GO:0046677]; response to gamma radiation [GO:0010332]; response to inorganic substance [GO:0010035]; response to ischemia [GO:0002931]; response to salt stress [GO:0009651]; response to X-ray [GO:0010165]; rRNA transcription [GO:0009303]; signal transduction by p53 class mediator [GO:0072331]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell proliferation involved in immune response [GO:0002309]; thymocyte apoptotic process [GO:0070242]; transcription initiation-coupled chromatin remodeling [GO:0045815]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type II interferon-mediated signaling pathway [GO:0060333]; viral process [GO:0016032]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; germ cell nucleus [GO:0043073]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]	14-3-3 protein binding [GO:0071889]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; copper ion binding [GO:0005507]; core promoter sequence-specific DNA binding [GO:0001046]; disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; general transcription initiation factor binding [GO:0140296]; histone deacetylase binding [GO:0042826]; histone deacetylase regulator activity [GO:0035033]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; molecular function activator activity [GO:0140677]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein phosphatase 2A binding [GO:0051721]; protein self-association [GO:0043621]; protein-folding chaperone binding [GO:0051087]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; TFIID-class transcription factor complex binding [GO:0001094]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; germ cell nucleus [GO:0043073]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]; 14-3-3 protein binding [GO:0071889]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; copper ion binding [GO:0005507]; core promoter sequence-specific DNA binding [GO:0001046]; disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; general transcription initiation factor binding [GO:0140296]; histone deacetylase binding [GO:0042826]; histone deacetylase regulator activity [GO:0035033]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; molecular function activator activity [GO:0140677]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein phosphatase 2A binding [GO:0051721]; protein self-association [GO:0043621]; protein-folding chaperone binding [GO:0051087]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; TFIID-class transcription factor complex binding [GO:0001094]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; autophagy [GO:0006914]; B cell lineage commitment [GO:0002326]; bone marrow development [GO:0048539]; cardiac muscle cell apoptotic process [GO:0010659]; cardiac septum morphogenesis [GO:0060411]; cellular response to actinomycin D [GO:0072717]; cellular response to gamma radiation [GO:0071480]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; cellular response to UV-C [GO:0071494]; cellular response to xenobiotic stimulus [GO:0071466]; cellular senescence [GO:0090398]; cerebellum development [GO:0021549]; chromosome organization [GO:0051276]; circadian behavior [GO:0048512]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; embryonic organ development [GO:0048568]; entrainment of circadian clock by photoperiod [GO:0043153]; ER overload response [GO:0006983]; fibroblast proliferation [GO:0048144]; gastrulation [GO:0007369]; glial cell proliferation [GO:0014009]; glucose catabolic process to lactate via pyruvate [GO:0019661]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell differentiation [GO:0060218]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; mitochondrial DNA repair [GO:0043504]; mitophagy [GO:0000423]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA transcription [GO:0009299]; multicellular organism growth [GO:0035264]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G1 to G0 transition [GO:1903451]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of glucose catabolic process to lactate via pyruvate [GO:1904024]; negative regulation of helicase activity [GO:0051097]; negative regulation of miRNA processing [GO:1903799]; negative regulation of mitophagy [GO:1901525]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of pentose-phosphate shunt [GO:1905856]; negative regulation of proteolysis [GO:0045861]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of telomerase activity [GO:0051974]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuroblast proliferation [GO:0007405]; neuron apoptotic process [GO:0051402]; nucleotide-excision repair [GO:0006289]; oligodendrocyte apoptotic process [GO:0097252]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cellular senescence [GO:2000774]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; protein-containing complex assembly [GO:0065003]; Ras protein signal transduction [GO:0007265]; reactive oxygen species metabolic process [GO:0072593]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of DNA-templated transcription [GO:0006355]; regulation of fibroblast apoptotic process [GO:2000269]; regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902253]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]; regulation of tissue remodeling [GO:0034103]; regulation of transcription by RNA polymerase II [GO:0006357]; release of cytochrome c from mitochondria [GO:0001836]; replicative senescence [GO:0090399]; response to antibiotic [GO:0046677]; response to gamma radiation [GO:0010332]; response to inorganic substance [GO:0010035]; response to ischemia [GO:0002931]; response to salt stress [GO:0009651]; response to X-ray [GO:0010165]; rRNA transcription [GO:0009303]; signal transduction by p53 class mediator [GO:0072331]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell proliferation involved in immune response [GO:0002309]; thymocyte apoptotic process [GO:0070242]; transcription initiation-coupled chromatin remodeling [GO:0045815]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type II interferon-mediated signaling pathway [GO:0060333]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17170702, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:21597459, ECO:0000269|PubMed:22726440}. Nucleus {ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17170702, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:21597459}. Nucleus, PML body {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12810724}. Endoplasmic reticulum {ECO:0000269|PubMed:17170702}. Mitochondrion matrix {ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:25168243, ECO:0000269|PubMed:27323408}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28842590}. Note=Recruited into PML bodies together with CHEK2 (PubMed:12810724). Translocates to mitochondria upon oxidative stress (PubMed:22726440). Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408). {ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:27323408}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:23752197}. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the cytoplasm in some cells.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm following cell stress.; SUBCELLULAR LOCATION: [Isoform 7]: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; SUBCELLULAR LOCATION: [Isoform 8]: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.; SUBCELLULAR LOCATION: [Isoform 9]: Cytoplasm.
P04731	reviewed	MT1A_HUMAN	Metallothionein-1A (MT-1A) (Metallothionein-IA) (MT-IA)	MT1A MT1S	Homo sapiens (Human)	61	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.		cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	
P04732	reviewed	MT1E_HUMAN	Metallothionein-1E (MT-1E) (Metallothionein-IE) (MT-IE)	MT1E	Homo sapiens (Human)	61	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.		cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	
P04733	reviewed	MT1F_HUMAN	Metallothionein-1F (MT-1F) (Metallothionein-IF) (MT-IF)	MT1F PRO0376	Homo sapiens (Human)	61	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.		cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	
P04746	reviewed	AMYP_HUMAN	Pancreatic alpha-amylase (PA) (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)	AMY2A	Homo sapiens (Human)	511			carbohydrate catabolic process [GO:0016052]; carbohydrate metabolic process [GO:0005975]; polysaccharide digestion [GO:0044245]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	alpha-amylase activity [GO:0004556]; calcium ion binding [GO:0005509]; chloride ion binding [GO:0031404]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; alpha-amylase activity [GO:0004556]; calcium ion binding [GO:0005509]; chloride ion binding [GO:0031404]; carbohydrate catabolic process [GO:0016052]; carbohydrate metabolic process [GO:0005975]; polysaccharide digestion [GO:0044245]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P04792	reviewed	HSPB1_HUMAN	Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27)	HSPB1 HSP27 HSP28	Homo sapiens (Human)	205	FUNCTION: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}.		anterograde axonal protein transport [GO:0099641]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chaperone-mediated protein folding [GO:0061077]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein kinase activity [GO:0006469]; platelet aggregation [GO:0070527]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of tumor necrosis factor production [GO:0032760]; protein refolding [GO:0042026]; regulation of autophagy [GO:0010506]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of protein phosphorylation [GO:0001932]; regulation of translational initiation [GO:0006446]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; response to virus [GO:0009615]; retina homeostasis [GO:0001895]	axon cytoplasm [GO:1904115]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; spindle [GO:0005819]; Z disc [GO:0030018]	identical protein binding [GO:0042802]; protein folding chaperone [GO:0044183]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein kinase C inhibitor activity [GO:0008426]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin binding [GO:0043130]; unfolded protein binding [GO:0051082]	axon cytoplasm [GO:1904115]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; spindle [GO:0005819]; Z disc [GO:0030018]; identical protein binding [GO:0042802]; protein folding chaperone [GO:0044183]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein kinase C inhibitor activity [GO:0008426]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin binding [GO:0043130]; unfolded protein binding [GO:0051082]; anterograde axonal protein transport [GO:0099641]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chaperone-mediated protein folding [GO:0061077]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein kinase activity [GO:0006469]; platelet aggregation [GO:0070527]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of tumor necrosis factor production [GO:0032760]; protein refolding [GO:0042026]; regulation of autophagy [GO:0010506]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of protein phosphorylation [GO:0001932]; regulation of translational initiation [GO:0006446]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; response to virus [GO:0009615]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10777697, ECO:0000269|PubMed:28144995}. Nucleus {ECO:0000269|PubMed:19464326}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10777697}. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. {ECO:0000269|PubMed:19464326}.
P04798	reviewed	CP1A1_HUMAN	Cytochrome P450 1A1 (CYPIA1) (EC 1.14.14.1) (Cytochrome P450 form 6) (Cytochrome P450-C) (Cytochrome P450-P1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)	CYP1A1	Homo sapiens (Human)	512	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15041462, ECO:0000269|PubMed:15805301, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20972997, ECO:0000269|PubMed:21068195}.		9-cis-retinoic acid biosynthetic process [GO:0042904]; amine metabolic process [GO:0009308]; camera-type eye development [GO:0043010]; cellular response to copper ion [GO:0071280]; cellular response to organic cyclic compound [GO:0071407]; coumarin metabolic process [GO:0009804]; dibenzo-p-dioxin catabolic process [GO:0019341]; digestive tract development [GO:0048565]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; ethylene metabolic process [GO:0009692]; fatty acid metabolic process [GO:0006631]; flavonoid metabolic process [GO:0009812]; hepatocyte differentiation [GO:0070365]; hydrogen peroxide biosynthetic process [GO:0050665]; insecticide metabolic process [GO:0017143]; lipid hydroxylation [GO:0002933]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty acid metabolic process [GO:0001676]; maternal process involved in parturition [GO:0060137]; omega-hydroxylase P450 pathway [GO:0097267]; porphyrin-containing compound metabolic process [GO:0006778]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; response to arsenic-containing substance [GO:0046685]; response to food [GO:0032094]; response to herbicide [GO:0009635]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to iron(III) ion [GO:0010041]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to vitamin A [GO:0033189]; retinol metabolic process [GO:0042572]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; vitamin D metabolic process [GO:0042359]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]	arachidonic acid monooxygenase activity [GO:0008391]; aromatase activity [GO:0070330]; demethylase activity [GO:0032451]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; flavonoid 3'-monooxygenase activity [GO:0016711]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; long-chain fatty acid omega-1 hydroxylase activity [GO:0120319]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on diphenols and related substances as donors [GO:0016679]; oxygen binding [GO:0019825]; vitamin D 24-hydroxylase activity [GO:0070576]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; arachidonic acid monooxygenase activity [GO:0008391]; aromatase activity [GO:0070330]; demethylase activity [GO:0032451]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; flavonoid 3'-monooxygenase activity [GO:0016711]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; long-chain fatty acid omega-1 hydroxylase activity [GO:0120319]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on diphenols and related substances as donors [GO:0016679]; oxygen binding [GO:0019825]; vitamin D 24-hydroxylase activity [GO:0070576]; 9-cis-retinoic acid biosynthetic process [GO:0042904]; amine metabolic process [GO:0009308]; camera-type eye development [GO:0043010]; cellular response to copper ion [GO:0071280]; cellular response to organic cyclic compound [GO:0071407]; coumarin metabolic process [GO:0009804]; dibenzo-p-dioxin catabolic process [GO:0019341]; digestive tract development [GO:0048565]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; ethylene metabolic process [GO:0009692]; fatty acid metabolic process [GO:0006631]; flavonoid metabolic process [GO:0009812]; hepatocyte differentiation [GO:0070365]; hydrogen peroxide biosynthetic process [GO:0050665]; insecticide metabolic process [GO:0017143]; lipid hydroxylation [GO:0002933]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty acid metabolic process [GO:0001676]; maternal process involved in parturition [GO:0060137]; omega-hydroxylase P450 pathway [GO:0097267]; porphyrin-containing compound metabolic process [GO:0006778]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; response to arsenic-containing substance [GO:0046685]; response to food [GO:0032094]; response to herbicide [GO:0009635]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to iron(III) ion [GO:0010041]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to vitamin A [GO:0033189]; retinol metabolic process [GO:0042572]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; vitamin D metabolic process [GO:0042359]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P00185}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00185}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00185}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00185}. Microsome membrane {ECO:0000250|UniProtKB:P00185}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00185}. Cytoplasm {ECO:0000250|UniProtKB:P00185}.
P04818	reviewed	TYSY_HUMAN	Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)	TYMS TS OK/SW-cl.29	Homo sapiens (Human)	313	FUNCTION: Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway. {ECO:0000269|PubMed:11278511, ECO:0000269|PubMed:21876188}.	MISCELLANEOUS: [Isoform 2]: Expressed both in normal and cancerous tissues. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Expressed only in cancerous tissues. {ECO:0000305}.	cartilage development [GO:0051216]; circadian rhythm [GO:0007623]; developmental growth [GO:0048589]; DNA biosynthetic process [GO:0071897]; dTMP biosynthetic process [GO:0006231]; dTTP biosynthetic process [GO:0006235]; intestinal epithelial cell maturation [GO:0060574]; liver regeneration [GO:0097421]; methylation [GO:0032259]; negative regulation of translation [GO:0017148]; response to cytokine [GO:0034097]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384]; response to organophosphorus [GO:0046683]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; tetrahydrofolate interconversion [GO:0035999]; uracil metabolic process [GO:0019860]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	folic acid binding [GO:0005542]; mRNA regulatory element binding translation repressor activity [GO:0000900]; protein homodimerization activity [GO:0042803]; sequence-specific mRNA binding [GO:1990825]; thymidylate synthase activity [GO:0004799]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; folic acid binding [GO:0005542]; mRNA regulatory element binding translation repressor activity [GO:0000900]; protein homodimerization activity [GO:0042803]; sequence-specific mRNA binding [GO:1990825]; thymidylate synthase activity [GO:0004799]; cartilage development [GO:0051216]; circadian rhythm [GO:0007623]; developmental growth [GO:0048589]; DNA biosynthetic process [GO:0071897]; dTMP biosynthetic process [GO:0006231]; dTTP biosynthetic process [GO:0006235]; intestinal epithelial cell maturation [GO:0060574]; liver regeneration [GO:0097421]; methylation [GO:0032259]; negative regulation of translation [GO:0017148]; response to cytokine [GO:0034097]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384]; response to organophosphorus [GO:0046683]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; tetrahydrofolate interconversion [GO:0035999]; uracil metabolic process [GO:0019860]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21876188}. Cytoplasm {ECO:0000269|PubMed:21876188}. Mitochondrion {ECO:0000269|PubMed:21876188}. Mitochondrion matrix {ECO:0000269|PubMed:21876188}. Mitochondrion inner membrane {ECO:0000269|PubMed:21876188}.
P04839	reviewed	CY24B_HUMAN	Cytochrome b-245 heavy chain (EC 1.-.-.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Heme-binding membrane glycoprotein gp91phox) (NADPH oxidase 2) (Neutrophil cytochrome b 91 kDa polypeptide) (Superoxide-generating NADPH oxidase heavy chain subunit) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome)	CYBB NOX2	Homo sapiens (Human)	570	FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.		cellular response to cadmium ion [GO:0071276]; cellular response to ethanol [GO:0071361]; cellular response to L-glutamine [GO:1904845]; defense response [GO:0006952]; electron transport chain [GO:0022900]; hydrogen peroxide biosynthetic process [GO:0050665]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of angiogenesis [GO:0045766]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of monoatomic ion transmembrane transport [GO:0034765]; respiratory burst [GO:0045730]; response to aldosterone [GO:1904044]; response to angiotensin [GO:1990776]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; NADPH oxidase complex [GO:0043020]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; perinuclear endoplasmic reticulum [GO:0097038]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; voltage-gated monoatomic ion channel activity [GO:0005244]	dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; NADPH oxidase complex [GO:0043020]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; perinuclear endoplasmic reticulum [GO:0097038]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; voltage-gated monoatomic ion channel activity [GO:0005244]; cellular response to cadmium ion [GO:0071276]; cellular response to ethanol [GO:0071361]; cellular response to L-glutamine [GO:1904845]; defense response [GO:0006952]; electron transport chain [GO:0022900]; hydrogen peroxide biosynthetic process [GO:0050665]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of angiogenesis [GO:0045766]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of monoatomic ion transmembrane transport [GO:0034765]; respiratory burst [GO:0045730]; response to aldosterone [GO:1904044]; response to angiotensin [GO:1990776]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=As unassembled monomer may localize to the endoplasmic reticulum. {ECO:0000305|PubMed:28351984}.
P04843	reviewed	RPN1_HUMAN	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)	RPN1	Homo sapiens (Human)	607	FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. {ECO:0000250|UniProtKB:E2RQ08, ECO:0000269|PubMed:31831667}.		protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; melanosome [GO:0042470]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; rough endoplasmic reticulum [GO:0005791]	RNA binding [GO:0003723]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; melanosome [GO:0042470]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; rough endoplasmic reticulum [GO:0005791]; RNA binding [GO:0003723]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:E2RQ08, ECO:0000250|UniProtKB:Q9GMB0}. Endoplasmic reticulum membrane; Single-pass type I membrane protein {ECO:0000305}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
P04844	reviewed	RPN2_HUMAN	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2)	RPN2	Homo sapiens (Human)	631	FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. {ECO:0000250|UniProtKB:F1PCT7, ECO:0000269|PubMed:31831667}.		protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear body [GO:0016604]; oligosaccharyltransferase complex [GO:0008250]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear body [GO:0016604]; oligosaccharyltransferase complex [GO:0008250]; protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:F1PCT7}. Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000305}.
P04899	reviewed	GNAI2_HUMAN	Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)	GNAI2 GNAI2B	Homo sapiens (Human)	355	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0140199]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of synaptic transmission [GO:0050805]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of urine volume [GO:0035810]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of calcium ion transport [GO:0051924]; response to nutrient [GO:0007584]; signal transduction [GO:0007165]	cell body [GO:0044297]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; midbody [GO:0030496]; neuronal dense core vesicle [GO:0098992]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	cell body [GO:0044297]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; midbody [GO:0030496]; neuronal dense core vesicle [GO:0098992]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0140199]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of synaptic transmission [GO:0050805]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of urine volume [GO:0035810]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of calcium ion transport [GO:0051924]; response to nutrient [GO:0007584]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17635935}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.
P04908	reviewed	H2A1B_HUMAN	Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)	H2AC4 H2AFM HIST1H2AB; H2AC8 H2AFA HIST1H2AE	Homo sapiens (Human)	130	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		chromatin organization [GO:0006325]; negative regulation of cell population proliferation [GO:0008285]; protein localization to CENP-A containing chromatin [GO:0061644]	CENP-A containing nucleosome [GO:0043505]; extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	CENP-A containing nucleosome [GO:0043505]; extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; chromatin organization [GO:0006325]; negative regulation of cell population proliferation [GO:0008285]; protein localization to CENP-A containing chromatin [GO:0061644]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P04920	reviewed	B3A2_HUMAN	Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2)	SLC4A2 AE2 EPB3L1 HKB3 MPB3L	Homo sapiens (Human)	1241	FUNCTION: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}.		amelogenesis [GO:0097186]; bicarbonate transport [GO:0015701]; digestive tract development [GO:0048565]; monoatomic anion transport [GO:0006820]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000565]; osteoclast differentiation [GO:0030316]; positive regulation of enamel mineralization [GO:0070175]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of intracellular pH [GO:0051453]; spermatogenesis [GO:0007283]; transmembrane transport [GO:0055085]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]	chloride:bicarbonate antiporter activity [GO:0140900]; enzyme binding [GO:0019899]; monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; chloride:bicarbonate antiporter activity [GO:0140900]; enzyme binding [GO:0019899]; monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857]; amelogenesis [GO:0097186]; bicarbonate transport [GO:0015701]; digestive tract development [GO:0048565]; monoatomic anion transport [GO:0006820]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000565]; osteoclast differentiation [GO:0030316]; positive regulation of enamel mineralization [GO:0070175]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of intracellular pH [GO:0051453]; spermatogenesis [GO:0007283]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: [Isoform A]: Apical cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform B1]: Apical cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform B2]: Apical cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15184086}; Multi-pass membrane protein {ECO:0000255}.
P04921	reviewed	GLPC_HUMAN	Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236)	GYPC GLPC GPC	Homo sapiens (Human)	128	FUNCTION: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.			cortical cytoskeleton [GO:0030863]; membrane [GO:0016020]; plasma membrane [GO:0005886]		cortical cytoskeleton [GO:0030863]; membrane [GO:0016020]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type III membrane protein. Note=Linked to the membrane via band 4.1.
P05000	reviewed	IFNW1_HUMAN	Interferon omega-1 (Interferon alpha-II-1)	IFNW1	Homo sapiens (Human)	195			adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; regulation of cell cycle [GO:0051726]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; regulation of cell cycle [GO:0051726]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
P05013	reviewed	IFNA6_HUMAN	Interferon alpha-6 (IFN-alpha-6) (Interferon alpha-54) (Interferon alpha-K) (LeIF K)	IFNA6	Homo sapiens (Human)	189	FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
P05014	reviewed	IFNA4_HUMAN	Interferon alpha-4 (IFN-alpha-4) (Interferon alpha-4B) (Interferon alpha-76) (Interferon alpha-M1)	IFNA4	Homo sapiens (Human)	189	FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
P05019	reviewed	IGF1_HUMAN	Insulin-like growth factor I (IGF-I) (Mechano growth factor) (MGF) (Somatomedin-C)	IGF1 IBP1	Homo sapiens (Human)	195	FUNCTION: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309). {ECO:0000250|UniProtKB:P05017, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:21076856, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:23243309, ECO:0000269|PubMed:23696648, ECO:0000269|PubMed:24132240}.	MISCELLANEOUS: [Isoform 3]: Expressed in liver. {ECO:0000305}.	activation of protein kinase B activity [GO:0032148]; bone mineralization involved in bone maturation [GO:0035630]; cell activation [GO:0001775]; cell population proliferation [GO:0008283]; cellular response to amyloid-beta [GO:1904646]; epithelial to mesenchymal transition [GO:0001837]; glycolate metabolic process [GO:0009441]; insulin-like growth factor receptor signaling pathway [GO:0048009]; muscle hypertrophy [GO:0014896]; muscle organ development [GO:0007517]; myoblast differentiation [GO:0045445]; myoblast proliferation [GO:0051450]; myotube cell development [GO:0014904]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of oocyte development [GO:0060283]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of glycolytic process [GO:0045821]; positive regulation of glycoprotein biosynthetic process [GO:0010560]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein secretion [GO:0050714]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of trophectodermal cell proliferation [GO:1904075]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein stabilization [GO:0050821]; proteoglycan biosynthetic process [GO:0030166]; Ras protein signal transduction [GO:0007265]; regulation of gene expression [GO:0010468]; regulation of protein phosphorylation [GO:0001932]; response to heat [GO:0009408]; signal transduction [GO:0007165]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; skeletal system development [GO:0001501]; wound healing [GO:0042060]	alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; exocytic vesicle [GO:0070382]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binding protein complex [GO:0016942]; insulin-like growth factor ternary complex [GO:0042567]; platelet alpha granule lumen [GO:0031093]	growth factor activity [GO:0008083]; hormone activity [GO:0005179]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; integrin binding [GO:0005178]	alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; exocytic vesicle [GO:0070382]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binding protein complex [GO:0016942]; insulin-like growth factor ternary complex [GO:0042567]; platelet alpha granule lumen [GO:0031093]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; integrin binding [GO:0005178]; activation of protein kinase B activity [GO:0032148]; bone mineralization involved in bone maturation [GO:0035630]; cell activation [GO:0001775]; cell population proliferation [GO:0008283]; cellular response to amyloid-beta [GO:1904646]; epithelial to mesenchymal transition [GO:0001837]; glycolate metabolic process [GO:0009441]; insulin-like growth factor receptor signaling pathway [GO:0048009]; muscle hypertrophy [GO:0014896]; muscle organ development [GO:0007517]; myoblast differentiation [GO:0045445]; myoblast proliferation [GO:0051450]; myotube cell development [GO:0014904]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of oocyte development [GO:0060283]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of glycolytic process [GO:0045821]; positive regulation of glycoprotein biosynthetic process [GO:0010560]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein secretion [GO:0050714]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of trophectodermal cell proliferation [GO:1904075]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein stabilization [GO:0050821]; proteoglycan biosynthetic process [GO:0030166]; Ras protein signal transduction [GO:0007265]; regulation of gene expression [GO:0010468]; regulation of protein phosphorylation [GO:0001932]; response to heat [GO:0009408]; signal transduction [GO:0007165]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; skeletal system development [GO:0001501]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P05017}.
P05023	reviewed	AT1A1_HUMAN	Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1)	ATP1A1	Homo sapiens (Human)	1023	FUNCTION: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to steroid hormone stimulus [GO:0071383]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; negative regulation of glucocorticoid biosynthetic process [GO:0031947]; negative regulation of heart contraction [GO:0045822]; positive regulation of heart contraction [GO:0045823]; positive regulation of striated muscle contraction [GO:0045989]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of blood pressure [GO:0008217]; regulation of sodium ion transport [GO:0002028]; regulation of the force of heart contraction [GO:0002026]; relaxation of cardiac muscle [GO:0055119]; response to glycoside [GO:1903416]; response to xenobiotic stimulus [GO:0009410]; sodium ion export across plasma membrane [GO:0036376]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; lateral plasma membrane [GO:0016328]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; organelle membrane [GO:0031090]; photoreceptor inner segment membrane [GO:0060342]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm flagellum [GO:0036126]; T-tubule [GO:0030315]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; phosphatase activity [GO:0016791]; potassium ion binding [GO:0030955]; protein heterodimerization activity [GO:0046982]; protein-folding chaperone binding [GO:0051087]; sodium ion binding [GO:0031402]; steroid hormone binding [GO:1990239]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; lateral plasma membrane [GO:0016328]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; organelle membrane [GO:0031090]; photoreceptor inner segment membrane [GO:0060342]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm flagellum [GO:0036126]; T-tubule [GO:0030315]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; phosphatase activity [GO:0016791]; potassium ion binding [GO:0030955]; protein heterodimerization activity [GO:0046982]; protein-folding chaperone binding [GO:0051087]; sodium ion binding [GO:0031402]; steroid hormone binding [GO:1990239]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to steroid hormone stimulus [GO:0071383]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; negative regulation of glucocorticoid biosynthetic process [GO:0031947]; negative regulation of heart contraction [GO:0045822]; positive regulation of heart contraction [GO:0045823]; positive regulation of striated muscle contraction [GO:0045989]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of blood pressure [GO:0008217]; regulation of sodium ion transport [GO:0002028]; regulation of the force of heart contraction [GO:0002026]; relaxation of cardiac muscle [GO:0055119]; response to glycoside [GO:1903416]; response to xenobiotic stimulus [GO:0009410]; sodium ion export across plasma membrane [GO:0036376]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:P06685}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P06685}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.
P05026	reviewed	AT1B1_HUMAN	Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)	ATP1B1 ATP1B	Homo sapiens (Human)	303	FUNCTION: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:19694409). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520). {ECO:0000269|PubMed:19694409, ECO:0000269|PubMed:34011520}.; FUNCTION: Involved in cell adhesion and establishing epithelial cell polarity. {ECO:0000269|PubMed:19694409}.		ATP metabolic process [GO:0046034]; cardiac muscle contraction [GO:0060048]; cell adhesion [GO:0007155]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; innate immune response [GO:0045087]; intracellular calcium ion homeostasis [GO:0006874]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; monoatomic cation transmembrane transport [GO:0098655]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of calcium:sodium antiporter activity [GO:1903281]; positive regulation of P-type sodium:potassium-exchanging transporter activity [GO:1903408]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion import across plasma membrane [GO:1990573]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; protein transport into plasma membrane raft [GO:0044861]; proton transmembrane transport [GO:1902600]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of gene expression [GO:0010468]; relaxation of cardiac muscle [GO:0055119]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm flagellum [GO:0036126]; T-tubule [GO:0030315]	ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; MHC class II protein complex binding [GO:0023026]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm flagellum [GO:0036126]; T-tubule [GO:0030315]; ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; MHC class II protein complex binding [GO:0023026]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; ATP metabolic process [GO:0046034]; cardiac muscle contraction [GO:0060048]; cell adhesion [GO:0007155]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; innate immune response [GO:0045087]; intracellular calcium ion homeostasis [GO:0006874]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; monoatomic cation transmembrane transport [GO:0098655]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of calcium:sodium antiporter activity [GO:1903281]; positive regulation of P-type sodium:potassium-exchanging transporter activity [GO:1903408]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion import across plasma membrane [GO:1990573]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; protein transport into plasma membrane raft [GO:0044861]; proton transmembrane transport [GO:1902600]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of gene expression [GO:0010468]; relaxation of cardiac muscle [GO:0055119]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:34011520}; Single-pass type II membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P07340}; Single-pass type II membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P14094}. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. {ECO:0000250|UniProtKB:P14094}.
P05060	reviewed	SCG1_HUMAN	Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide]	CHGB SCG1	Homo sapiens (Human)	677	FUNCTION: Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.			endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; secretory granule [GO:0030141]	hormone activity [GO:0005179]	endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; hormone activity [GO:0005179]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25326458}. Note=Neuroendocrine and endocrine secretory granules.
P05062	reviewed	ALDOB_HUMAN	Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase)	ALDOB ALDB	Homo sapiens (Human)	364	FUNCTION: Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). {ECO:0000269|PubMed:10970798, ECO:0000269|PubMed:12205126, ECO:0000269|PubMed:20848650, ECO:0000269|PubMed:35122041}.	MISCELLANEOUS: In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.	fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; NADH oxidation [GO:0006116]; negative regulation of pentose-phosphate shunt [GO:1905856]; positive regulation of ATP-dependent activity [GO:0032781]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule organizing center [GO:0005815]	ATPase binding [GO:0051117]; cytoskeletal protein binding [GO:0008092]; fructose binding [GO:0070061]; fructose-1-phosphate aldolase activity [GO:0061609]; fructose-bisphosphate aldolase activity [GO:0004332]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule organizing center [GO:0005815]; ATPase binding [GO:0051117]; cytoskeletal protein binding [GO:0008092]; fructose binding [GO:0070061]; fructose-1-phosphate aldolase activity [GO:0061609]; fructose-bisphosphate aldolase activity [GO:0004332]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; NADH oxidation [GO:0006116]; negative regulation of pentose-phosphate shunt [GO:1905856]; positive regulation of ATP-dependent activity [GO:0032781]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:35122041}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:18000879}.
P05067	reviewed	A4_HUMAN	Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]	APP A4 AD1	Homo sapiens (Human)	770	FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. {ECO:0000250, ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:17062754, ECO:0000269|PubMed:23011729, ECO:0000269|PubMed:25122912}.; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta protein 42 is a more effective reductant than amyloid-beta protein 40. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. APP42-beta may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. {ECO:0000250}.; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.; FUNCTION: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).	MISCELLANEOUS: Chelation of metal ions, notably copper, iron and zinc, can induce histidine-bridging between amyloid-beta molecules resulting in amyloid-beta-metal aggregates. The affinity for copper is much higher than for other transient metals and is increased under acidic conditions. Extracellular zinc-binding increases binding of heparin to APP and inhibits collagen-binding. {ECO:0000269|PubMed:26898943, ECO:0000269|PubMed:28570778}.; MISCELLANEOUS: [Isoform APP770]: A major isoform.; MISCELLANEOUS: [Isoform L-APP677]: The L-isoforms are referred to as appicans. {ECO:0000305}.; MISCELLANEOUS: [Isoform APP695]: A major isoform. {ECO:0000305}.; MISCELLANEOUS: [Isoform L-APP696]: The L-isoforms are referred to as appicans. {ECO:0000305}.; MISCELLANEOUS: [Isoform L-APP733]: The L-isoforms are referred to as appicans. {ECO:0000305}.; MISCELLANEOUS: [Isoform APP751]: A major isoform. {ECO:0000305}.	adult locomotory behavior [GO:0008344]; amyloid fibril formation [GO:1990000]; astrocyte activation [GO:0048143]; astrocyte activation involved in immune response [GO:0002265]; axo-dendritic transport [GO:0008088]; axon midline choice point recognition [GO:0016199]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cellular response to amyloid-beta [GO:1904646]; central nervous system development [GO:0007417]; cholesterol metabolic process [GO:0008203]; cognition [GO:0050890]; collateral sprouting in absence of injury [GO:0048669]; cytoplasmic polyadenylation [GO:0180011]; dendrite development [GO:0016358]; endocytosis [GO:0006897]; extracellular matrix organization [GO:0030198]; forebrain development [GO:0030900]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular copper ion homeostasis [GO:0006878]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; mating behavior [GO:0007617]; microglia development [GO:0014005]; microglial cell activation [GO:0001774]; modulation of excitatory postsynaptic potential [GO:0098815]; mRNA polyadenylation [GO:0006378]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of neuron differentiation [GO:0045665]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; neuron cellular homeostasis [GO:0070050]; neuron projection development [GO:0031175]; neuron projection maintenance [GO:1990535]; neuron remodeling [GO:0016322]; Notch signaling pathway [GO:0007219]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of chemokine production [GO:0032722]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein binding [GO:0032092]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell migration [GO:2000406]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein phosphorylation [GO:0006468]; regulation of epidermal growth factor-activated receptor activity [GO:0007176]; regulation of gene expression [GO:0010468]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of multicellular organism growth [GO:0040014]; regulation of NMDA receptor activity [GO:2000310]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of presynapse assembly [GO:1905606]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synapse structure or activity [GO:0050803]; regulation of translation [GO:0006417]; regulation of Wnt signaling pathway [GO:0030111]; response to interleukin-1 [GO:0070555]; response to oxidative stress [GO:0006979]; smooth endoplasmic reticulum calcium ion homeostasis [GO:0051563]; suckling behavior [GO:0001967]; synapse organization [GO:0050808]; synaptic assembly at neuromuscular junction [GO:0051124]; visual learning [GO:0008542]	apical part of cell [GO:0045177]; axon [GO:0030424]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; ciliary rootlet [GO:0035253]; clathrin-coated pit [GO:0005905]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; endosome lumen [GO:0031904]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi-associated vesicle [GO:0005798]; growth cone [GO:0030426]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuromuscular junction [GO:0031594]; nuclear envelope lumen [GO:0005641]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; presynaptic active zone [GO:0048786]; receptor complex [GO:0043235]; recycling endosome [GO:0055037]; smooth endoplasmic reticulum [GO:0005790]; spindle midzone [GO:0051233]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; PTB domain binding [GO:0051425]; receptor ligand activity [GO:0048018]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor activator activity [GO:0030546]; signaling receptor binding [GO:0005102]; transition metal ion binding [GO:0046914]	apical part of cell [GO:0045177]; axon [GO:0030424]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; ciliary rootlet [GO:0035253]; clathrin-coated pit [GO:0005905]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; endosome lumen [GO:0031904]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi-associated vesicle [GO:0005798]; growth cone [GO:0030426]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuromuscular junction [GO:0031594]; nuclear envelope lumen [GO:0005641]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; presynaptic active zone [GO:0048786]; receptor complex [GO:0043235]; recycling endosome [GO:0055037]; smooth endoplasmic reticulum [GO:0005790]; spindle midzone [GO:0051233]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; PTB domain binding [GO:0051425]; receptor ligand activity [GO:0048018]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor activator activity [GO:0030546]; signaling receptor binding [GO:0005102]; transition metal ion binding [GO:0046914]; adult locomotory behavior [GO:0008344]; amyloid fibril formation [GO:1990000]; astrocyte activation [GO:0048143]; astrocyte activation involved in immune response [GO:0002265]; axo-dendritic transport [GO:0008088]; axon midline choice point recognition [GO:0016199]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cellular response to amyloid-beta [GO:1904646]; central nervous system development [GO:0007417]; cholesterol metabolic process [GO:0008203]; cognition [GO:0050890]; collateral sprouting in absence of injury [GO:0048669]; cytoplasmic polyadenylation [GO:0180011]; dendrite development [GO:0016358]; endocytosis [GO:0006897]; extracellular matrix organization [GO:0030198]; forebrain development [GO:0030900]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular copper ion homeostasis [GO:0006878]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; mating behavior [GO:0007617]; microglia development [GO:0014005]; microglial cell activation [GO:0001774]; modulation of excitatory postsynaptic potential [GO:0098815]; mRNA polyadenylation [GO:0006378]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of neuron differentiation [GO:0045665]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; neuron cellular homeostasis [GO:0070050]; neuron projection development [GO:0031175]; neuron projection maintenance [GO:1990535]; neuron remodeling [GO:0016322]; Notch signaling pathway [GO:0007219]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of chemokine production [GO:0032722]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein binding [GO:0032092]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell migration [GO:2000406]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein phosphorylation [GO:0006468]; regulation of epidermal growth factor-activated receptor activity [GO:0007176]; regulation of gene expression [GO:0010468]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of multicellular organism growth [GO:0040014]; regulation of NMDA receptor activity [GO:2000310]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of presynapse assembly [GO:1905606]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synapse structure or activity [GO:0050803]; regulation of translation [GO:0006417]; regulation of Wnt signaling pathway [GO:0030111]; response to interleukin-1 [GO:0070555]; response to oxidative stress [GO:0006979]; smooth endoplasmic reticulum calcium ion homeostasis [GO:0051563]; suckling behavior [GO:0001967]; synapse organization [GO:0050808]; synaptic assembly at neuromuscular junction [GO:0051124]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10383380, ECO:0000269|PubMed:20580937, ECO:0000269|PubMed:2649245, ECO:0000305|PubMed:25122912}; Single-pass type I membrane protein {ECO:0000269|PubMed:30630874, ECO:0000305|PubMed:10383380, ECO:0000305|PubMed:25122912}. Membrane {ECO:0000269|PubMed:2900137, ECO:0000305|PubMed:22584060}; Single-pass type I membrane protein {ECO:0000269|PubMed:2900137, ECO:0000269|PubMed:30630874, ECO:0000305|PubMed:22584060}. Perikaryon {ECO:0000269|PubMed:10341243}. Cell projection, growth cone {ECO:0000269|PubMed:10341243}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:20580937}. Early endosome {ECO:0000269|PubMed:20580937}. Cytoplasmic vesicle {ECO:0000269|PubMed:20580937, ECO:0000269|PubMed:25122912}. Note=Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proportion is present at the cell membrane; most of the protein is present in intracellular vesicles (PubMed:20580937). During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. APP sorts to the basolateral surface in epithelial cells. During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body (PubMed:10341243). Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment. Associates with GPC1 in perinuclear compartments. Colocalizes with SORL1 in a vesicular pattern in cytoplasm and perinuclear regions. {ECO:0000269|PubMed:10341243, ECO:0000269|PubMed:20580937}.; SUBCELLULAR LOCATION: [C83]: Endoplasmic reticulum {ECO:0000269|PubMed:14527950}. Golgi apparatus {ECO:0000269|PubMed:14527950}. Early endosome {ECO:0000269|PubMed:14527950}.; SUBCELLULAR LOCATION: [C99]: Early endosome {ECO:0000269|PubMed:14527950}.; SUBCELLULAR LOCATION: [Soluble APP-beta]: Secreted {ECO:0000269|PubMed:10656250, ECO:0000269|PubMed:2649245}.; SUBCELLULAR LOCATION: [Amyloid-beta protein 40]: Cell surface {ECO:0000269|PubMed:16154999}.; SUBCELLULAR LOCATION: [Amyloid-beta protein 42]: Cell surface {ECO:0000269|PubMed:11689470, ECO:0000269|PubMed:16154999}. Note=Associates with FPR2 at the cell surface and the complex is then rapidly internalized. {ECO:0000269|PubMed:11689470}.; SUBCELLULAR LOCATION: [Gamma-secretase C-terminal fragment 59]: Nucleus {ECO:0000269|PubMed:11544248}. Cytoplasm {ECO:0000269|PubMed:11544248}. Note=Located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65) (PubMed:11544248). In dopaminergic neurons, the phosphorylated Thr-743 form is localized to the nucleus (By similarity). {ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:11544248}.
P05089	reviewed	ARGI1_HUMAN	Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)	ARG1	Homo sapiens (Human)	322	FUNCTION: Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. {ECO:0000305}.; FUNCTION: Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed:15546957, PubMed:16709924, PubMed:19380772). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure. {ECO:0000250|UniProtKB:Q61176, ECO:0000269|PubMed:15546957, ECO:0000269|PubMed:16709924, ECO:0000269|PubMed:19380772}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site. {ECO:0000305}.	adaptive immune response [GO:0002250]; arginine catabolic process [GO:0006527]; arginine catabolic process to ornithine [GO:0019547]; defense response to protozoan [GO:0042832]; innate immune response [GO:0045087]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; positive regulation of neutrophil mediated killing of fungus [GO:0070965]; urea cycle [GO:0000050]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]	arginase activity [GO:0004053]; manganese ion binding [GO:0030145]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]; arginase activity [GO:0004053]; manganese ion binding [GO:0030145]; adaptive immune response [GO:0002250]; arginine catabolic process [GO:0006527]; arginine catabolic process to ornithine [GO:0019547]; defense response to protozoan [GO:0042832]; innate immune response [GO:0045087]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; positive regulation of neutrophil mediated killing of fungus [GO:0070965]; urea cycle [GO:0000050]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16141327}. Cytoplasmic granule {ECO:0000269|PubMed:15546957}. Note=Localized in azurophil granules of neutrophils (PubMed:15546957). {ECO:0000269|PubMed:15546957}.
P05090	reviewed	APOD_HUMAN	Apolipoprotein D (Apo-D) (ApoD)	APOD	Homo sapiens (Human)	189	FUNCTION: APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.	MISCELLANEOUS: APOD is primarily localized in HDL (60-65%), with most of the remainder in VHDL and only trace amounts in VLDL and LDL.	angiogenesis [GO:0001525]; brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246]	cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]	cholesterol binding [GO:0015485]; lipid transporter activity [GO:0005319]	cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; cholesterol binding [GO:0015485]; lipid transporter activity [GO:0005319]; angiogenesis [GO:0001525]; brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Secreted.
P05091	reviewed	ALDH2_HUMAN	Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI)	ALDH2 ALDM	Homo sapiens (Human)	517	FUNCTION: Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. {ECO:0000269|PubMed:33355142}.		alcohol metabolic process [GO:0006066]; aldehyde catabolic process [GO:0046185]; carbohydrate metabolic process [GO:0005975]; ethanol catabolic process [GO:0006068]; regulation of dopamine biosynthetic process [GO:1903179]; regulation of serotonin biosynthetic process [GO:1905627]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; carboxylesterase activity [GO:0106435]; electron transfer activity [GO:0009055]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; NAD binding [GO:0051287]; nitroglycerin reductase activity [GO:0018547]; phenylacetaldehyde dehydrogenase activity [GO:0008957]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; carboxylesterase activity [GO:0106435]; electron transfer activity [GO:0009055]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; NAD binding [GO:0051287]; nitroglycerin reductase activity [GO:0018547]; phenylacetaldehyde dehydrogenase activity [GO:0008957]; alcohol metabolic process [GO:0006066]; aldehyde catabolic process [GO:0046185]; carbohydrate metabolic process [GO:0005975]; ethanol catabolic process [GO:0006068]; regulation of dopamine biosynthetic process [GO:1903179]; regulation of serotonin biosynthetic process [GO:1905627]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P05093	reviewed	CP17A_HUMAN	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)	CYP17A1 CYP17 S17AH	Homo sapiens (Human)	508	FUNCTION: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis (PubMed:9452426, PubMed:27339894, PubMed:22266943, PubMed:25301938). Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (PubMed:9452426, PubMed:25301938) (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione (PubMed:9452426, PubMed:27339894, PubMed:22266943, PubMed:25301938, PubMed:36640554). Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA (PubMed:36640554). Also 16-alpha hydroxylates androgens, relevant for estriol synthesis (PubMed:27339894, PubMed:25301938). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:9452426, PubMed:27339894, PubMed:22266943, PubMed:25301938). {ECO:0000269|PubMed:22266943, ECO:0000269|PubMed:25301938, ECO:0000269|PubMed:27339894, ECO:0000269|PubMed:36640554, ECO:0000269|PubMed:9452426, ECO:0000305|PubMed:8027220}.		androgen biosynthetic process [GO:0006702]; glucocorticoid biosynthetic process [GO:0006704]; hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]	axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]	17-alpha-hydroxyprogesterone aldolase activity [GO:0047442]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxygen binding [GO:0019825]; steroid 17-alpha-monooxygenase activity [GO:0004508]	axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; 17-alpha-hydroxyprogesterone aldolase activity [GO:0047442]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxygen binding [GO:0019825]; steroid 17-alpha-monooxygenase activity [GO:0004508]; androgen biosynthetic process [GO:0006702]; glucocorticoid biosynthetic process [GO:0006704]; hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:2808364}. Microsome membrane {ECO:0000305|PubMed:2808364}.
P05106	reviewed	ITB3_HUMAN	Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)	ITGB3 GP3A	Homo sapiens (Human)	788	FUNCTION: Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). {ECO:0000250|UniProtKB:O54890, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:9195946, ECO:0000303|PubMed:16322781, ECO:0000303|PubMed:17635696}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9. {ECO:0000269|PubMed:7519807}.; FUNCTION: (Microbial infection) Acts as a receptor for Hantaan virus. {ECO:0000269|PubMed:9618541}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:15834425}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB3 acts as a receptor for Human metapneumovirus. {ECO:0000269|PubMed:24478423}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.		activation of protein kinase activity [GO:0032147]; angiogenesis involved in wound healing [GO:0060055]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; apoptotic cell clearance [GO:0043277]; blood coagulation [GO:0007596]; blood coagulation, fibrin clot formation [GO:0072378]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to mechanical stimulus [GO:0071260]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to xenobiotic stimulus [GO:0071466]; embryo implantation [GO:0007566]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; maintenance of postsynaptic specialization structure [GO:0098880]; mesodermal cell differentiation [GO:0048333]; negative chemotaxis [GO:0050919]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway [GO:1900731]; positive regulation of angiogenesis [GO:0045766]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of extracellular matrix organization [GO:1903053]; regulation of postsynaptic neurotransmitter receptor diffusion trapping [GO:0150054]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of protein localization [GO:0032880]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of serotonin uptake [GO:0051611]; regulation of trophoblast cell migration [GO:1901163]; response to activity [GO:0014823]; smooth muscle cell migration [GO:0014909]; substrate adhesion-dependent cell spreading [GO:0034446]; tube development [GO:0035295]; viral entry into host cell [GO:0046718]; wound healing [GO:0042060]	alpha9-beta1 integrin-ADAM8 complex [GO:0071133]; alphav-beta3 integrin-HMGB1 complex [GO:0035868]; alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; alphav-beta3 integrin-PKCalpha complex [GO:0035866]; alphav-beta3 integrin-vitronectin complex [GO:0071062]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; glycinergic synapse [GO:0098690]; integrin alphav-beta3 complex [GO:0034683]; integrin complex [GO:0008305]; lamellipodium membrane [GO:0031258]; melanosome [GO:0042470]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; synapse [GO:0045202]	cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; enzyme binding [GO:0019899]; extracellular matrix binding [GO:0050840]; fibrinogen binding [GO:0070051]; fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor receptor binding [GO:0005161]; protease binding [GO:0002020]; protein disulfide isomerase activity [GO:0003756]; protein kinase C binding [GO:0005080]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; virus receptor activity [GO:0001618]	alpha9-beta1 integrin-ADAM8 complex [GO:0071133]; alphav-beta3 integrin-HMGB1 complex [GO:0035868]; alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; alphav-beta3 integrin-PKCalpha complex [GO:0035866]; alphav-beta3 integrin-vitronectin complex [GO:0071062]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; glycinergic synapse [GO:0098690]; integrin alphav-beta3 complex [GO:0034683]; integrin complex [GO:0008305]; lamellipodium membrane [GO:0031258]; melanosome [GO:0042470]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; synapse [GO:0045202]; cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; enzyme binding [GO:0019899]; extracellular matrix binding [GO:0050840]; fibrinogen binding [GO:0070051]; fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor receptor binding [GO:0005161]; protease binding [GO:0002020]; protein disulfide isomerase activity [GO:0003756]; protein kinase C binding [GO:0005080]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; virus receptor activity [GO:0001618]; activation of protein kinase activity [GO:0032147]; angiogenesis involved in wound healing [GO:0060055]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; apoptotic cell clearance [GO:0043277]; blood coagulation [GO:0007596]; blood coagulation, fibrin clot formation [GO:0072378]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to mechanical stimulus [GO:0071260]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to xenobiotic stimulus [GO:0071466]; embryo implantation [GO:0007566]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; maintenance of postsynaptic specialization structure [GO:0098880]; mesodermal cell differentiation [GO:0048333]; negative chemotaxis [GO:0050919]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway [GO:1900731]; positive regulation of angiogenesis [GO:0045766]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of extracellular matrix organization [GO:1903053]; regulation of postsynaptic neurotransmitter receptor diffusion trapping [GO:0150054]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of protein localization [GO:0032880]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of serotonin uptake [GO:0051611]; regulation of trophoblast cell migration [GO:1901163]; response to activity [GO:0014823]; smooth muscle cell migration [GO:0014909]; substrate adhesion-dependent cell spreading [GO:0034446]; tube development [GO:0035295]; viral entry into host cell [GO:0046718]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}; Single-pass type I membrane protein {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:20702409}. Cell junction, focal adhesion {ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:35687021}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:O54890}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O54890}. Synapse {ECO:0000250|UniProtKB:O54890}.
P05107	reviewed	ITB2_HUMAN	Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)	ITGB2 CD18 MFI7	Homo sapiens (Human)	769	FUNCTION: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). {ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:28807980, ECO:0000269|PubMed:29100055}.		amyloid-beta clearance [GO:0097242]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell-cell signaling [GO:0007267]; cell-matrix adhesion [GO:0007160]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; endodermal cell differentiation [GO:0035987]; heterotypic cell-cell adhesion [GO:0034113]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; microglial cell activation [GO:0001774]; negative regulation of dopamine metabolic process [GO:0045963]; neutrophil chemotaxis [GO:0030593]; neutrophil migration [GO:1990266]; phagocytosis, engulfment [GO:0006911]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of prostaglandin-E synthase activity [GO:2000363]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of superoxide anion generation [GO:0032930]; receptor clustering [GO:0043113]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of cell shape [GO:0008360]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; integrin alphaL-beta2 complex [GO:0034687]; integrin alphaM-beta2 complex [GO:0034688]; integrin alphaX-beta2 complex [GO:0034689]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	amyloid-beta binding [GO:0001540]; cell adhesion molecule binding [GO:0050839]; complement component C3b binding [GO:0001851]; heat shock protein binding [GO:0031072]; ICAM-3 receptor activity [GO:0030369]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; integrin alphaL-beta2 complex [GO:0034687]; integrin alphaM-beta2 complex [GO:0034688]; integrin alphaX-beta2 complex [GO:0034689]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; amyloid-beta binding [GO:0001540]; cell adhesion molecule binding [GO:0050839]; complement component C3b binding [GO:0001851]; heat shock protein binding [GO:0031072]; ICAM-3 receptor activity [GO:0030369]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; amyloid-beta clearance [GO:0097242]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell-cell signaling [GO:0007267]; cell-matrix adhesion [GO:0007160]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; endodermal cell differentiation [GO:0035987]; heterotypic cell-cell adhesion [GO:0034113]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; microglial cell activation [GO:0001774]; negative regulation of dopamine metabolic process [GO:0045963]; neutrophil chemotaxis [GO:0030593]; neutrophil migration [GO:1990266]; phagocytosis, engulfment [GO:0006911]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of prostaglandin-E synthase activity [GO:2000363]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of superoxide anion generation [GO:0032930]; receptor clustering [GO:0043113]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of cell shape [GO:0008360]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:28807980}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:21193407}; Single-pass type I membrane protein {ECO:0000305}.
P05108	reviewed	CP11A_HUMAN	Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (CYPXIA1) (Cholesterol desmolase) (Cytochrome P450 11A1) (Cytochrome P450(scc))	CYP11A1 CYP11A	Homo sapiens (Human)	521	FUNCTION: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:21636783). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (PubMed:21636783). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:21636783). {ECO:0000269|PubMed:21636783}.		C21-steroid hormone biosynthetic process [GO:0006700]; cellular response to peptide hormone stimulus [GO:0071375]; cholesterol metabolic process [GO:0008203]; cortisol metabolic process [GO:0034650]; glucocorticoid biosynthetic process [GO:0006704]; sterol metabolic process [GO:0016125]; vitamin D metabolic process [GO:0042359]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	cholesterol monooxygenase (side-chain-cleaving) activity [GO:0008386]; heme binding [GO:0020037]; iron ion binding [GO:0005506]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; cholesterol monooxygenase (side-chain-cleaving) activity [GO:0008386]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; C21-steroid hormone biosynthetic process [GO:0006700]; cellular response to peptide hormone stimulus [GO:0071375]; cholesterol metabolic process [GO:0008203]; cortisol metabolic process [GO:0034650]; glucocorticoid biosynthetic process [GO:0006704]; sterol metabolic process [GO:0016125]; vitamin D metabolic process [GO:0042359]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P14137}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the matrix side of the mitochondrion inner membrane. {ECO:0000250|UniProtKB:P14137}.
P05109	reviewed	S10A8_HUMAN	Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A)	S100A8 CAGA CFAG MRP8	Homo sapiens (Human)	93	FUNCTION: S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity. {ECO:0000269|PubMed:12626582, ECO:0000269|PubMed:15331440, ECO:0000269|PubMed:15598812, ECO:0000269|PubMed:15642721, ECO:0000269|PubMed:16258195, ECO:0000269|PubMed:19087201, ECO:0000269|PubMed:19122197, ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:21487906, ECO:0000269|PubMed:22363402, ECO:0000269|PubMed:22808130, ECO:0000269|PubMed:25417112}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, may induce expansion of aberrant immature neutrophils in a TLR4-dependent manner. {ECO:0000305|PubMed:33388094}.	MISCELLANEOUS: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; astrocyte development [GO:0014002]; autocrine signaling [GO:0035425]; autophagy [GO:0006914]; chronic inflammatory response [GO:0002544]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; leukocyte migration involved in inflammatory response [GO:0002523]; neutrophil aggregation [GO:0070488]; neutrophil chemotaxis [GO:0030593]; peptide secretion [GO:0002790]; peptidyl-cysteine S-nitrosylation [GO:0018119]; positive regulation of cell growth [GO:0030307]; positive regulation of inflammatory response [GO:0050729]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptide secretion [GO:0002793]; regulation of cytoskeleton organization [GO:0051493]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to zinc ion [GO:0010043]; sequestering of zinc ion [GO:0032119]	collagen-containing extracellular matrix [GO:0062023]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]	arachidonic acid binding [GO:0050544]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; microtubule binding [GO:0008017]; RAGE receptor binding [GO:0050786]; Toll-like receptor 4 binding [GO:0035662]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; arachidonic acid binding [GO:0050544]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; microtubule binding [GO:0008017]; RAGE receptor binding [GO:0050786]; Toll-like receptor 4 binding [GO:0035662]; zinc ion binding [GO:0008270]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; astrocyte development [GO:0014002]; autocrine signaling [GO:0035425]; autophagy [GO:0006914]; chronic inflammatory response [GO:0002544]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; leukocyte migration involved in inflammatory response [GO:0002523]; neutrophil aggregation [GO:0070488]; neutrophil chemotaxis [GO:0030593]; peptide secretion [GO:0002790]; peptidyl-cysteine S-nitrosylation [GO:0018119]; positive regulation of cell growth [GO:0030307]; positive regulation of inflammatory response [GO:0050729]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptide secretion [GO:0002793]; regulation of cytoskeleton organization [GO:0051493]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to zinc ion [GO:0010043]; sequestering of zinc ion [GO:0032119]	SUBCELLULAR LOCATION: Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.
P05111	reviewed	INHA_HUMAN	Inhibin alpha chain	INHA	Homo sapiens (Human)	366	FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.		cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; erythrocyte differentiation [GO:0030218]; hemoglobin biosynthetic process [GO:0042541]; male gonad development [GO:0008584]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of cell cycle [GO:0045786]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of phosphorylation [GO:0042326]; negative regulation of type II interferon production [GO:0032689]; ovarian follicle development [GO:0001541]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; inhibin A complex [GO:0043512]; inhibin B complex [GO:0043513]; inhibin-betaglycan-ActRII complex [GO:0034673]; neuronal cell body [GO:0043025]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; inhibin binding [GO:0034711]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; inhibin A complex [GO:0043512]; inhibin B complex [GO:0043513]; inhibin-betaglycan-ActRII complex [GO:0034673]; neuronal cell body [GO:0043025]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; inhibin binding [GO:0034711]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; erythrocyte differentiation [GO:0030218]; hemoglobin biosynthetic process [GO:0042541]; male gonad development [GO:0008584]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of cell cycle [GO:0045786]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of phosphorylation [GO:0042326]; negative regulation of type II interferon production [GO:0032689]; ovarian follicle development [GO:0001541]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted.
P05112	reviewed	IL4_HUMAN	Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)	IL4	Homo sapiens (Human)	153	FUNCTION: Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:3016727, PubMed:1993171). Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:1993171). Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (PubMed:2521231). Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (By similarity). Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells (PubMed:10219247, PubMed:11526337, PubMed:18243101). Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6 (PubMed:7721895). {ECO:0000250|UniProtKB:P07750, ECO:0000269|PubMed:10219247, ECO:0000269|PubMed:11526337, ECO:0000269|PubMed:18243101}.		activation of Janus kinase activity [GO:0042976]; B cell costimulation [GO:0031296]; B cell differentiation [GO:0030183]; cholesterol metabolic process [GO:0008203]; dendritic cell differentiation [GO:0097028]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; immune response [GO:0006955]; innate immune response in mucosa [GO:0002227]; interleukin-4-mediated signaling pathway [GO:0035771]; macrophage activation [GO:0042116]; microglial cell activation [GO:0001774]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of complement-dependent cytotoxicity [GO:1903660]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of inflammatory response [GO:0050728]; negative regulation of macrophage activation [GO:0043031]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; neuroinflammatory response [GO:0150076]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular respiration [GO:1901857]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of eosinophil chemotaxis [GO:2000424]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of isotype switching to IgE isotypes [GO:0048295]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of immune response [GO:0050776]; regulation of isotype switching [GO:0045191]; regulation of phosphorylation [GO:0042325]; T cell activation [GO:0042110]; T-helper 2 cell differentiation [GO:0045064]; type 2 immune response [GO:0042092]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-4 receptor binding [GO:0005136]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-4 receptor binding [GO:0005136]; activation of Janus kinase activity [GO:0042976]; B cell costimulation [GO:0031296]; B cell differentiation [GO:0030183]; cholesterol metabolic process [GO:0008203]; dendritic cell differentiation [GO:0097028]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; immune response [GO:0006955]; innate immune response in mucosa [GO:0002227]; interleukin-4-mediated signaling pathway [GO:0035771]; macrophage activation [GO:0042116]; microglial cell activation [GO:0001774]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of complement-dependent cytotoxicity [GO:1903660]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of inflammatory response [GO:0050728]; negative regulation of macrophage activation [GO:0043031]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; neuroinflammatory response [GO:0150076]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular respiration [GO:1901857]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of eosinophil chemotaxis [GO:2000424]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of isotype switching to IgE isotypes [GO:0048295]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of immune response [GO:0050776]; regulation of isotype switching [GO:0045191]; regulation of phosphorylation [GO:0042325]; T cell activation [GO:0042110]; T-helper 2 cell differentiation [GO:0045064]; type 2 immune response [GO:0042092]	SUBCELLULAR LOCATION: Secreted.
P05113	reviewed	IL5_HUMAN	Interleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF)	IL5	Homo sapiens (Human)	134	FUNCTION: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276). Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB (PubMed:1495999, PubMed:22528658). Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (PubMed:7613138). {ECO:0000250|UniProtKB:P04401, ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:22528658, ECO:0000269|PubMed:2653458, ECO:0000269|PubMed:7613138, ECO:0000269|PubMed:9010276}.		immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-5-mediated signaling pathway [GO:0038043]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of eosinophil differentiation [GO:0045645]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of podosome assembly [GO:0071803]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-5 receptor binding [GO:0005137]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-5 receptor binding [GO:0005137]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-5-mediated signaling pathway [GO:0038043]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of eosinophil differentiation [GO:0045645]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of podosome assembly [GO:0071803]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2653458}.
P05114	reviewed	HMGN1_HUMAN	Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1)	HMGN1 HMG14	Homo sapiens (Human)	100	FUNCTION: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}.		chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; post-embryonic camera-type eye morphogenesis [GO:0048597]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; regulation of development, heterochronic [GO:0040034]; regulation of epithelial cell proliferation [GO:0050678]; regulation of transcription by RNA polymerase II [GO:0006357]; response to UV-B [GO:0010224]; response to UV-C [GO:0010225]; transcription-coupled nucleotide-excision repair [GO:0006283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; nucleosomal DNA binding [GO:0031492]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; nucleosomal DNA binding [GO:0031492]; chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; post-embryonic camera-type eye morphogenesis [GO:0048597]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; regulation of development, heterochronic [GO:0040034]; regulation of epithelial cell proliferation [GO:0050678]; regulation of transcription by RNA polymerase II [GO:0006357]; response to UV-B [GO:0010224]; response to UV-C [GO:0010225]; transcription-coupled nucleotide-excision repair [GO:0006283]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
P05120	reviewed	PAI2_HUMAN	Plasminogen activator inhibitor 2 (PAI-2) (Monocyte Arg-serpin) (Placental plasminogen activator inhibitor) (Serpin B2) (Urokinase inhibitor)	SERPINB2 PAI2 PLANH2	Homo sapiens (Human)	415	FUNCTION: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.		fibrinolysis [GO:0042730]; negative regulation of apoptotic process [GO:0043066]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	serine-type endopeptidase inhibitor activity [GO:0004867]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; serine-type endopeptidase inhibitor activity [GO:0004867]; fibrinolysis [GO:0042730]; negative regulation of apoptotic process [GO:0043066]	SUBCELLULAR LOCATION: Cytoplasm. Secreted, extracellular space.
P05121	reviewed	PAI1_HUMAN	Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)	SERPINE1 PAI1 PLANH1	Homo sapiens (Human)	402	FUNCTION: Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084). {ECO:0000250|UniProtKB:P22777, ECO:0000269|PubMed:15001579, ECO:0000269|PubMed:15853774, ECO:0000269|PubMed:16862142, ECO:0000269|PubMed:17912461, ECO:0000269|PubMed:18386027, ECO:0000269|PubMed:25808697, ECO:0000269|PubMed:27046084, ECO:0000269|PubMed:8481516, ECO:0000269|PubMed:9168821, ECO:0000269|PubMed:9175705, ECO:0000269|PubMed:9207454}.		angiogenesis [GO:0001525]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-negative bacterium [GO:0050829]; dentinogenesis [GO:0097187]; fibrinolysis [GO:0042730]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell migration [GO:0030336]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukotriene production involved in inflammatory response [GO:0035491]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of signaling receptor activity [GO:0010469]; replicative senescence [GO:0090399]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; peptidase inhibitor complex [GO:1904090]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; serine protease inhibitor complex [GO:0097180]	protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; peptidase inhibitor complex [GO:1904090]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; serine protease inhibitor complex [GO:0097180]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]; angiogenesis [GO:0001525]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-negative bacterium [GO:0050829]; dentinogenesis [GO:0097187]; fibrinolysis [GO:0042730]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell migration [GO:0030336]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukotriene production involved in inflammatory response [GO:0035491]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of signaling receptor activity [GO:0010469]; replicative senescence [GO:0090399]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2430793}.
P05129	reviewed	KPCG_HUMAN	Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13)	PRKCG PKCG	Homo sapiens (Human)	697	FUNCTION: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624}.		chemical synaptic transmission [GO:0007268]; chemosensory behavior [GO:0007635]; innervation [GO:0060384]; intracellular signal transduction [GO:0035556]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; phosphorylation [GO:0016310]; positive regulation of mismatch repair [GO:0032425]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of phagocytosis [GO:0050764]; regulation of response to food [GO:0032095]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to morphine [GO:0043278]; response to pain [GO:0048265]; response to psychosocial stress [GO:1990911]; response to toxic substance [GO:0009636]; rhythmic process [GO:0048511]	calyx of Held [GO:0044305]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; presynaptic cytosol [GO:0099523]; synaptic membrane [GO:0097060]	ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; zinc ion binding [GO:0008270]	calyx of Held [GO:0044305]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; presynaptic cytosol [GO:0099523]; synaptic membrane [GO:0097060]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; zinc ion binding [GO:0008270]; chemical synaptic transmission [GO:0007268]; chemosensory behavior [GO:0007635]; innervation [GO:0060384]; intracellular signal transduction [GO:0035556]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; phosphorylation [GO:0016310]; positive regulation of mismatch repair [GO:0032425]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of phagocytosis [GO:0050764]; regulation of response to food [GO:0032095]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to morphine [GO:0043278]; response to pain [GO:0048265]; response to psychosocial stress [GO:1990911]; response to toxic substance [GO:0009636]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P63318}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:29053796}; Peripheral membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250|UniProtKB:P63318}. Cell projection, dendrite {ECO:0000250|UniProtKB:P63319}. Note=Translocates to synaptic membranes on stimulation. {ECO:0000250|UniProtKB:P63318}.
P05141	reviewed	ADT2_HUMAN	ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]	SLC25A5 AAC2 ANT2	Homo sapiens (Human)	298	FUNCTION: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P51881, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:31883789}.		adaptive thermogenesis [GO:1990845]; adenine nucleotide transport [GO:0051503]; B cell differentiation [GO:0030183]; cellular response to leukemia inhibitory factor [GO:1990830]; chromosome segregation [GO:0007059]; erythrocyte differentiation [GO:0030218]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mitophagy [GO:1901526]; regulation of mitochondrial membrane permeability [GO:0046902]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; MMXD complex [GO:0071817]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	adenine nucleotide transmembrane transporter activity [GO:0000295]; adenine transmembrane transporter activity [GO:0015207]; ATP:ADP antiporter activity [GO:0005471]; oxidative phosphorylation uncoupler activity [GO:0017077]; proton transmembrane transporter activity [GO:0015078]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; MMXD complex [GO:0071817]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; adenine nucleotide transmembrane transporter activity [GO:0000295]; adenine transmembrane transporter activity [GO:0015207]; ATP:ADP antiporter activity [GO:0005471]; oxidative phosphorylation uncoupler activity [GO:0017077]; proton transmembrane transporter activity [GO:0015078]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; adaptive thermogenesis [GO:1990845]; adenine nucleotide transport [GO:0051503]; B cell differentiation [GO:0030183]; cellular response to leukemia inhibitory factor [GO:1990830]; chromosome segregation [GO:0007059]; erythrocyte differentiation [GO:0030218]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mitophagy [GO:1901526]; regulation of mitochondrial membrane permeability [GO:0046902]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P02722}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:27641616}; Multi-pass membrane protein {ECO:0000255}. Note=May localize to non-mitochondrial membranes. {ECO:0000269|PubMed:27641616}.
P05154	reviewed	IPSP_HUMAN	Plasma serine protease inhibitor (Acrosomal serine protease inhibitor) (Plasminogen activator inhibitor 3) (PAI-3) (PAI3) (Protein C inhibitor) (PCI) (Serpin A5)	SERPINA5 PCI PLANH3 PROCI	Homo sapiens (Human)	406	FUNCTION: Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and pro-inflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue- and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid. {ECO:0000269|PubMed:10340997, ECO:0000269|PubMed:11722589, ECO:0000269|PubMed:14696115, ECO:0000269|PubMed:15140131, ECO:0000269|PubMed:15328353, ECO:0000269|PubMed:15853774, ECO:0000269|PubMed:1725227, ECO:0000269|PubMed:18467335, ECO:0000269|PubMed:2844223, ECO:0000269|PubMed:3501295, ECO:0000269|PubMed:6323392, ECO:0000269|PubMed:7521127, ECO:0000269|PubMed:7548057, ECO:0000269|PubMed:8536714, ECO:0000269|PubMed:8665956, ECO:0000269|PubMed:9473218, ECO:0000269|PubMed:9510955, ECO:0000269|PubMed:9556620}.		fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; lipid transport [GO:0006869]; negative regulation of hydrolase activity [GO:0051346]; spermatogenesis [GO:0007283]	acrosomal membrane [GO:0002080]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule [GO:0031091]; platelet dense tubular network [GO:0031094]; protein C inhibitor-coagulation factor V complex [GO:0097181]; protein C inhibitor-coagulation factor Xa complex [GO:0097182]; protein C inhibitor-coagulation factor XI complex [GO:0097183]; protein C inhibitor-KLK3 complex [GO:0036029]; protein C inhibitor-plasma kallikrein complex [GO:0036030]; protein C inhibitor-PLAT complex [GO:0036026]; protein C inhibitor-PLAU complex [GO:0036027]; protein C inhibitor-thrombin complex [GO:0036028]; protein C inhibitor-TMPRSS11E complex [GO:0036025]; protein C inhibitor-TMPRSS7 complex [GO:0036024]; protein-containing complex [GO:0032991]	acrosin binding [GO:0032190]; glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; phosphatidylcholine binding [GO:0031210]; protease binding [GO:0002020]; retinoic acid binding [GO:0001972]; serine-type endopeptidase inhibitor activity [GO:0004867]	acrosomal membrane [GO:0002080]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule [GO:0031091]; platelet dense tubular network [GO:0031094]; protein C inhibitor-coagulation factor V complex [GO:0097181]; protein C inhibitor-coagulation factor Xa complex [GO:0097182]; protein C inhibitor-coagulation factor XI complex [GO:0097183]; protein C inhibitor-KLK3 complex [GO:0036029]; protein C inhibitor-plasma kallikrein complex [GO:0036030]; protein C inhibitor-PLAT complex [GO:0036026]; protein C inhibitor-PLAU complex [GO:0036027]; protein C inhibitor-thrombin complex [GO:0036028]; protein C inhibitor-TMPRSS11E complex [GO:0036025]; protein C inhibitor-TMPRSS7 complex [GO:0036024]; protein-containing complex [GO:0032991]; acrosin binding [GO:0032190]; glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; phosphatidylcholine binding [GO:0031210]; protease binding [GO:0002020]; retinoic acid binding [GO:0001972]; serine-type endopeptidase inhibitor activity [GO:0004867]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; lipid transport [GO:0006869]; negative regulation of hydrolase activity [GO:0051346]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:1725227, ECO:0000269|PubMed:18467335, ECO:0000269|PubMed:7521127, ECO:0000269|PubMed:8536714, ECO:0000269|PubMed:9510955, ECO:0000269|PubMed:9556620}. Note=Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spermatozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets.
P05155	reviewed	IC1_HUMAN	Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1)	SERPING1 C1IN C1NH	Homo sapiens (Human)	500	FUNCTION: Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. {ECO:0000269|PubMed:8495195}.		blood circulation [GO:0008015]; blood coagulation [GO:0007596]; complement activation, classical pathway [GO:0006958]; fibrinolysis [GO:0042730]; innate immune response [GO:0045087]; negative regulation of complement activation, lectin pathway [GO:0001869]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]	serine-type endopeptidase inhibitor activity [GO:0004867]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; serine-type endopeptidase inhibitor activity [GO:0004867]; blood circulation [GO:0008015]; blood coagulation [GO:0007596]; complement activation, classical pathway [GO:0006958]; fibrinolysis [GO:0042730]; innate immune response [GO:0045087]; negative regulation of complement activation, lectin pathway [GO:0001869]	SUBCELLULAR LOCATION: Secreted.
P05156	reviewed	CFAI_HUMAN	Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain]	CFI IF	Homo sapiens (Human)	583	FUNCTION: Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins (PubMed:7360115, PubMed:17320177). Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces (PubMed:2141838, PubMed:9605165, PubMed:12055245). The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization (PubMed:28671664). {ECO:0000269|PubMed:12055245, ECO:0000269|PubMed:17320177, ECO:0000269|PubMed:2141838, ECO:0000269|PubMed:28671664, ECO:0000269|PubMed:7360115, ECO:0000269|PubMed:9605165}.		complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]	metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space. Secreted {ECO:0000269|PubMed:6327681}.
P05160	reviewed	F13B_HUMAN	Coagulation factor XIII B chain (Fibrin-stabilizing factor B subunit) (Protein-glutamine gamma-glutamyltransferase B chain) (Transglutaminase B chain)	F13B	Homo sapiens (Human)	661	FUNCTION: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. {ECO:0000303|PubMed:21742792, ECO:0000303|PubMed:3021194}.		blood coagulation [GO:0007596]; blood coagulation, fibrin clot formation [GO:0072378]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; transferase complex [GO:1990234]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; transferase complex [GO:1990234]; blood coagulation [GO:0007596]; blood coagulation, fibrin clot formation [GO:0072378]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26247044, ECO:0000269|PubMed:4405643}.
P05161	reviewed	ISG15_HUMAN	Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein) (hUCRP)	ISG15 G1P2 UCRP	Homo sapiens (Human)	165	FUNCTION: Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein (PubMed:33727702). Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Isgylation of the viral sensor IFIH1/MDA5 promotes IFIH1/MDA5 oligomerization and triggers activation of innate immunity against a range of viruses, including coronaviruses, flaviviruses and picornaviruses (PubMed:33727702). Can also isgylate: EIF2AK2/PKR which results in its activation, RIGI which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity, UBE2N and UBE2E1 which negatively regulates their activity, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade thereby inhibiting IFNA-induced JNK signaling. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A, HIV-1 and Ebola virus. Restricts HIV-1 and ebola virus via disruption of viral budding. Inhibits the ubiquitination of HIV-1 Gag and host TSG101 and disrupts their interaction, thereby preventing assembly and release of virions from infected cells. Inhibits Ebola virus budding mediated by the VP40 protein by disrupting ubiquitin ligase activity of NEDD4 and its ability to ubiquitinate VP40. ISGylates influenza A virus NS1 protein which causes a loss of function of the protein and the inhibition of virus replication. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity. The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (PubMed:29100055). {ECO:0000269|PubMed:1373138, ECO:0000269|PubMed:16009940, ECO:0000269|PubMed:16112642, ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:16434471, ECO:0000269|PubMed:16872604, ECO:0000269|PubMed:18305167, ECO:0000269|PubMed:19270716, ECO:0000269|PubMed:19357168, ECO:0000269|PubMed:2005397, ECO:0000269|PubMed:20133869, ECO:0000269|PubMed:20308324, ECO:0000269|PubMed:20639253, ECO:0000269|PubMed:21543490, ECO:0000269|PubMed:22693631, ECO:0000269|PubMed:22859821, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:29100055, ECO:0000269|PubMed:33727702, ECO:0000269|PubMed:7526157, ECO:0000269|PubMed:8550581}.		defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; ISG15-protein conjugation [GO:0032020]; modification-dependent protein catabolic process [GO:0019941]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; positive regulation of bone mineralization [GO:0030501]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of protein oligomerization [GO:0032461]; positive regulation of type II interferon production [GO:0032729]; protein localization to mitochondrion [GO:0070585]; regulation of type II interferon production [GO:0032649]; response to type I interferon [GO:0034340]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]	integrin binding [GO:0005178]; protein tag activity [GO:0031386]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; integrin binding [GO:0005178]; protein tag activity [GO:0031386]; ubiquitin protein ligase binding [GO:0031625]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; ISG15-protein conjugation [GO:0032020]; modification-dependent protein catabolic process [GO:0019941]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; positive regulation of bone mineralization [GO:0030501]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of protein oligomerization [GO:0032461]; positive regulation of type II interferon production [GO:0032729]; protein localization to mitochondrion [GO:0070585]; regulation of type II interferon production [GO:0032649]; response to type I interferon [GO:0034340]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22859821}. Secreted {ECO:0000269|PubMed:22859821}. Note=Exists in three distinct states: free within the cell, released into the extracellular space, or conjugated to target proteins.
P05162	reviewed	LEG2_HUMAN	Galectin-2 (Gal-2) (Beta-galactoside-binding lectin L-14-II) (HL14) (Lactose-binding lectin 2) (S-Lac lectin 2)	LGALS2	Homo sapiens (Human)	132	FUNCTION: This protein binds beta-galactoside. Its physiological function is not yet known.		cell-cell adhesion [GO:0098609]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inflammatory response [GO:0050729]; T cell homeostasis [GO:0043029]	galectin complex [GO:1990724]	carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936]	galectin complex [GO:1990724]; carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936]; cell-cell adhesion [GO:0098609]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inflammatory response [GO:0050729]; T cell homeostasis [GO:0043029]	
P05164	reviewed	PERM_HUMAN	Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]	MPO	Homo sapiens (Human)	745	FUNCTION: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971). {ECO:0000269|PubMed:25698971, ECO:0000269|PubMed:9922160}.		defense response [GO:0006952]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; hydrogen peroxide catabolic process [GO:0042744]; hypochlorous acid biosynthetic process [GO:0002149]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of apoptotic process [GO:0043066]; removal of superoxide radicals [GO:0019430]; respiratory burst involved in defense response [GO:0002679]; response to food [GO:0032094]; response to gold nanoparticle [GO:1990268]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to oxidative stress [GO:0006979]; response to yeast [GO:0001878]	azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle lumen [GO:0097013]; secretory granule [GO:0030141]	chromatin binding [GO:0003682]; heme binding [GO:0020037]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]	azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle lumen [GO:0097013]; secretory granule [GO:0030141]; chromatin binding [GO:0003682]; heme binding [GO:0020037]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; hydrogen peroxide catabolic process [GO:0042744]; hypochlorous acid biosynthetic process [GO:0002149]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of apoptotic process [GO:0043066]; removal of superoxide radicals [GO:0019430]; respiratory burst involved in defense response [GO:0002679]; response to food [GO:0032094]; response to gold nanoparticle [GO:1990268]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to oxidative stress [GO:0006979]; response to yeast [GO:0001878]	SUBCELLULAR LOCATION: Lysosome.
P05165	reviewed	PCCA_HUMAN	Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)	PCCA	Homo sapiens (Human)	728	FUNCTION: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:8434582, PubMed:6765947). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:8434582, PubMed:6765947, PubMed:10101253). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:6765947). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). {ECO:0000250|UniProtKB:P0DTA4, ECO:0000250|UniProtKB:Q5LUF3, ECO:0000269|PubMed:10101253, ECO:0000269|PubMed:6765947, ECO:0000269|PubMed:8434582}.		branched-chain amino acid metabolic process [GO:0009081]; fatty acid metabolic process [GO:0006631]; short-chain fatty acid catabolic process [GO:0019626]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; biotin binding [GO:0009374]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; propionyl-CoA carboxylase activity [GO:0004658]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; biotin binding [GO:0009374]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; propionyl-CoA carboxylase activity [GO:0004658]; branched-chain amino acid metabolic process [GO:0009081]; fatty acid metabolic process [GO:0006631]; short-chain fatty acid catabolic process [GO:0019626]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:10101253, ECO:0000269|PubMed:16023992}.
P05166	reviewed	PCCB_HUMAN	Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)	PCCB	Homo sapiens (Human)	539	FUNCTION: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:6765947, PubMed:15890657). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:6765947, PubMed:15890657). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:6765947). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). {ECO:0000250|UniProtKB:P79384, ECO:0000250|UniProtKB:Q168G2, ECO:0000269|PubMed:15890657, ECO:0000269|PubMed:6765947}.		branched-chain amino acid metabolic process [GO:0009081]; fatty acid metabolic process [GO:0006631]; short-chain fatty acid catabolic process [GO:0019626]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; propionyl-CoA carboxylase activity [GO:0004658]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; propionyl-CoA carboxylase activity [GO:0004658]; branched-chain amino acid metabolic process [GO:0009081]; fatty acid metabolic process [GO:0006631]; short-chain fatty acid catabolic process [GO:0019626]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:16023992}.
P05177	reviewed	CP1A2_HUMAN	Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)	CYP1A2	Homo sapiens (Human)	516	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14725854, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:21068195, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:9435160, ECO:0000305|PubMed:16522833}.		aflatoxin metabolic process [GO:0046222]; alkaloid metabolic process [GO:0009820]; cellular respiration [GO:0045333]; cellular response to cadmium ion [GO:0071276]; cholesterol metabolic process [GO:0008203]; dibenzo-p-dioxin metabolic process [GO:0018894]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; heterocycle metabolic process [GO:0046483]; hydrogen peroxide biosynthetic process [GO:0050665]; long-chain fatty acid biosynthetic process [GO:0042759]; lung development [GO:0030324]; methylation [GO:0032259]; monocarboxylic acid metabolic process [GO:0032787]; monoterpenoid metabolic process [GO:0016098]; omega-hydroxylase P450 pathway [GO:0097267]; oxidative demethylation [GO:0070989]; porphyrin-containing compound metabolic process [GO:0006778]; post-embryonic development [GO:0009791]; regulation of gene expression [GO:0010468]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; toxin biosynthetic process [GO:0009403]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	aromatase activity [GO:0070330]; caffeine oxidase activity [GO:0034875]; demethylase activity [GO:0032451]; electron transfer activity [GO:0009055]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; aromatase activity [GO:0070330]; caffeine oxidase activity [GO:0034875]; demethylase activity [GO:0032451]; electron transfer activity [GO:0009055]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; aflatoxin metabolic process [GO:0046222]; alkaloid metabolic process [GO:0009820]; cellular respiration [GO:0045333]; cellular response to cadmium ion [GO:0071276]; cholesterol metabolic process [GO:0008203]; dibenzo-p-dioxin metabolic process [GO:0018894]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; heterocycle metabolic process [GO:0046483]; hydrogen peroxide biosynthetic process [GO:0050665]; long-chain fatty acid biosynthetic process [GO:0042759]; lung development [GO:0030324]; methylation [GO:0032259]; monocarboxylic acid metabolic process [GO:0032787]; monoterpenoid metabolic process [GO:0016098]; omega-hydroxylase P450 pathway [GO:0097267]; oxidative demethylation [GO:0070989]; porphyrin-containing compound metabolic process [GO:0006778]; post-embryonic development [GO:0009791]; regulation of gene expression [GO:0010468]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; toxin biosynthetic process [GO:0009403]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:21576599}; Peripheral membrane protein.
P05181	reviewed	CP2E1_HUMAN	Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J)	CYP2E1 CYP2E	Homo sapiens (Human)	493	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}.		4-nitrophenol metabolic process [GO:0018960]; benzene metabolic process [GO:0018910]; carbon tetrachloride metabolic process [GO:0018885]; epoxygenase P450 pathway [GO:0019373]; halogenated hydrocarbon metabolic process [GO:0042197]; heterocycle metabolic process [GO:0046483]; lipid hydroxylation [GO:0002933]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty acid metabolic process [GO:0001676]; monoterpenoid metabolic process [GO:0016098]; response to bacterium [GO:0009617]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]	4-nitrophenol 2-monooxygenase activity [GO:0018601]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron ion binding [GO:0005506]; long-chain fatty acid omega-1 hydroxylase activity [GO:0120319]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; 4-nitrophenol 2-monooxygenase activity [GO:0018601]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron ion binding [GO:0005506]; long-chain fatty acid omega-1 hydroxylase activity [GO:0120319]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; 4-nitrophenol metabolic process [GO:0018960]; benzene metabolic process [GO:0018910]; carbon tetrachloride metabolic process [GO:0018885]; epoxygenase P450 pathway [GO:0019373]; halogenated hydrocarbon metabolic process [GO:0042197]; heterocycle metabolic process [GO:0046483]; lipid hydroxylation [GO:0002933]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty acid metabolic process [GO:0001676]; monoterpenoid metabolic process [GO:0016098]; response to bacterium [GO:0009617]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P05182}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05182}. Microsome membrane {ECO:0000250|UniProtKB:P05182}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05182}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P05182}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05182}. Note=Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. {ECO:0000250|UniProtKB:P05182}.
P05186	reviewed	PPBT_HUMAN	Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNS-ALP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1)	ALPL	Homo sapiens (Human)	524	FUNCTION: Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis (PubMed:12162492, PubMed:23688511, PubMed:25982064). Has broad substrate specificity and can hydrolyze a considerable variety of compounds: however, only a few substrates, such as diphosphate (inorganic pyrophosphate; PPi), pyridoxal 5'-phosphate (PLP) and N-phosphocreatine are natural substrates (PubMed:12162492, PubMed:2220817). Plays an essential role in skeletal and dental mineralization via its ability to hydrolyze extracellular diphosphate, a potent mineralization inhibitor, to phosphate: it thereby promotes hydroxyapatite crystal formation and increases inorganic phosphate concentration (PubMed:23688511, PubMed:25982064). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity). Also promotes dephosphorylation of osteopontin (SSP1), an inhibitor of hydroxyapatite crystallization in its phosphorylated state; it is however unclear whether ALPL/TNAP mediates SSP1 dephosphorylation via a direct or indirect manner (By similarity). Catalyzes dephosphorylation of PLP to pyridoxal (PL), the transportable form of vitamin B6, in order to provide a sufficient amount of PLP in the brain, an essential cofactor for enzymes catalyzing the synthesis of diverse neurotransmitters (PubMed:2220817, PubMed:20049532). Additionally, also able to mediate ATP degradation in a stepwise manner to adenosine, thereby regulating the availability of ligands for purinergic receptors (By similarity). Also capable of dephosphorylating microbial products, such as lipopolysaccharides (LPS) as well as other phosphorylated small-molecules, such as poly-inosine:cytosine (poly I:C) (PubMed:28448526). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating hydrolysis of N-phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:P09242, ECO:0000269|PubMed:12162492, ECO:0000269|PubMed:20049532, ECO:0000269|PubMed:2220817, ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064, ECO:0000269|PubMed:28448526}.	MISCELLANEOUS: In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non-specific (liver/bone/kidney) (ALPL/TNAP). {ECO:0000305}.	bone mineralization [GO:0030282]; calcium ion homeostasis [GO:0055074]; cellular homeostasis [GO:0019725]; cellular response to organic cyclic compound [GO:0071407]; cementum mineralization [GO:0071529]; dephosphorylation [GO:0016311]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; futile creatine cycle [GO:0140651]; inhibition of non-skeletal tissue mineralization [GO:0140928]; osteoblast differentiation [GO:0001649]; phosphate ion homeostasis [GO:0055062]; positive regulation of cold-induced thermogenesis [GO:0120162]; pyridoxal phosphate metabolic process [GO:0042822]; response to antibiotic [GO:0046677]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to macrophage colony-stimulating factor [GO:0036005]; response to sodium phosphate [GO:1904383]; response to vitamin B6 [GO:0034516]; response to vitamin D [GO:0033280]; skeletal system development [GO:0001501]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	ADP phosphatase activity [GO:0043262]; alkaline phosphatase activity [GO:0004035]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; inorganic diphosphate phosphatase activity [GO:0004427]; phosphoamidase activity [GO:0050187]; phosphoethanolamine phosphatase activity [GO:0052732]; pyridoxal phosphatase activity [GO:0033883]; pyrophosphatase activity [GO:0016462]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; ADP phosphatase activity [GO:0043262]; alkaline phosphatase activity [GO:0004035]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; inorganic diphosphate phosphatase activity [GO:0004427]; phosphoamidase activity [GO:0050187]; phosphoethanolamine phosphatase activity [GO:0052732]; pyridoxal phosphatase activity [GO:0033883]; pyrophosphatase activity [GO:0016462]; bone mineralization [GO:0030282]; calcium ion homeostasis [GO:0055074]; cellular homeostasis [GO:0019725]; cellular response to organic cyclic compound [GO:0071407]; cementum mineralization [GO:0071529]; dephosphorylation [GO:0016311]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; futile creatine cycle [GO:0140651]; inhibition of non-skeletal tissue mineralization [GO:0140928]; osteoblast differentiation [GO:0001649]; phosphate ion homeostasis [GO:0055062]; positive regulation of cold-induced thermogenesis [GO:0120162]; pyridoxal phosphate metabolic process [GO:0042822]; response to antibiotic [GO:0046677]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to macrophage colony-stimulating factor [GO:0036005]; response to sodium phosphate [GO:1904383]; response to vitamin B6 [GO:0034516]; response to vitamin D [GO:0033280]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2220817, ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064, ECO:0000269|PubMed:33821301}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064}. Extracellular vesicle membrane {ECO:0000250|UniProtKB:P09242}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P09242}. Mitochondrion membrane {ECO:0000250|UniProtKB:P09242}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P09242}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P09242}. Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. Localizes to the mitochondria of thermogenic fat cells: tethered to mitochondrial membranes via a GPI-anchor and probably resides in the mitochondrion intermembrane space. {ECO:0000250|UniProtKB:P09242}.
P05187	reviewed	PPB1_HUMAN	Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1)	ALPP PLAP	Homo sapiens (Human)	535	FUNCTION: Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}.	MISCELLANEOUS: In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non-specific (liver/bone/kidney) (ALPL/TNAP).	dephosphorylation [GO:0016311]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	alkaline phosphatase activity [GO:0004035]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; alkaline phosphatase activity [GO:0004035]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270]; dephosphorylation [GO:0016311]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1730777, ECO:0000269|PubMed:2153284}.
P05198	reviewed	IF2A_HUMAN	Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha)	EIF2S1 EIF2A	Homo sapiens (Human)	315	FUNCTION: Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352}.		cellular response to amino acid starvation [GO:0034198]; cellular response to heat [GO:0034605]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; negative regulation of translational initiation in response to stress [GO:0032057]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; regulation of translation in response to endoplasmic reticulum stress [GO:0036490]; regulation of translational initiation in response to stress [GO:0043558]; response to endoplasmic reticulum stress [GO:0034976]; response to kainic acid [GO:1904373]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; stress granule assembly [GO:0034063]; translational initiation [GO:0006413]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular exosome [GO:0070062]; glial limiting end-foot [GO:0097451]; membrane [GO:0016020]; nucleus [GO:0005634]; polysome [GO:0005844]; synapse [GO:0045202]; translation initiation ternary complex [GO:0044207]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular exosome [GO:0070062]; glial limiting end-foot [GO:0097451]; membrane [GO:0016020]; nucleus [GO:0005634]; polysome [GO:0005844]; synapse [GO:0045202]; translation initiation ternary complex [GO:0044207]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; cellular response to amino acid starvation [GO:0034198]; cellular response to heat [GO:0034605]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; negative regulation of translational initiation in response to stress [GO:0032057]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; regulation of translation in response to endoplasmic reticulum stress [GO:0036490]; regulation of translational initiation in response to stress [GO:0043558]; response to endoplasmic reticulum stress [GO:0034976]; response to kainic acid [GO:1904373]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; stress granule assembly [GO:0034063]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q6ZWX6}. Note=Colocalizes with NANOS3 in the stress granules. {ECO:0000250|UniProtKB:Q6ZWX6}.
P05204	reviewed	HMGN2_HUMAN	Non-histone chromosomal protein HMG-17 (High mobility group nucleosome-binding domain-containing protein 2)	HMGN2 HMG17	Homo sapiens (Human)	90	FUNCTION: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). {ECO:0000250}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chromatin organization [GO:0006325]; killing of cells of another organism [GO:0031640]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chromatin organization [GO:0006325]; killing of cells of another organism [GO:0031640]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10739259}. Cytoplasm {ECO:0000269|PubMed:10739259}. Note=Cytoplasmic enrichment upon phosphorylation.
P05230	reviewed	FGF1_HUMAN	Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1)	FGF1 FGFA	Homo sapiens (Human)	155	FUNCTION: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107). {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:20145243, ECO:0000269|PubMed:20422052, ECO:0000269|PubMed:23469107, ECO:0000269|PubMed:8663044}.		activation of protein kinase B activity [GO:0032148]; anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; branch elongation involved in ureteric bud branching [GO:0060681]; cell differentiation [GO:0030154]; cellular response to heat [GO:0034605]; epithelial cell proliferation [GO:0050673]; fibroblast growth factor receptor signaling pathway [GO:0008543]; lung development [GO:0030324]; mesonephric epithelium development [GO:0072163]; organ induction [GO:0001759]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000544]; regulation of endothelial tube morphogenesis [GO:1901509]; signal transduction [GO:0007165]; wound healing [GO:0042060]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; Hsp70 protein binding [GO:0030544]; integrin binding [GO:0005178]; S100 protein binding [GO:0044548]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; Hsp70 protein binding [GO:0030544]; integrin binding [GO:0005178]; S100 protein binding [GO:0044548]; activation of protein kinase B activity [GO:0032148]; anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; branch elongation involved in ureteric bud branching [GO:0060681]; cell differentiation [GO:0030154]; cellular response to heat [GO:0034605]; epithelial cell proliferation [GO:0050673]; fibroblast growth factor receptor signaling pathway [GO:0008543]; lung development [GO:0030324]; mesonephric epithelium development [GO:0072163]; organ induction [GO:0001759]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000544]; regulation of endothelial tube morphogenesis [GO:1901509]; signal transduction [GO:0007165]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. {ECO:0000250}.
P05231	reviewed	IL6_HUMAN	Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)	IL6 IFNB2	Homo sapiens (Human)	212	FUNCTION: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). {ECO:0000305|PubMed:30995492}.; FUNCTION: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (Probable). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity). {ECO:0000250|UniProtKB:P08505, ECO:0000305|PubMed:30995492}.; FUNCTION: Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability (PubMed:17075861, PubMed:12794819). Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF (PubMed:12794819). Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (PubMed:20823453). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis (By similarity). Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (Probable). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (PubMed:15124018). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity). {ECO:0000250|UniProtKB:P08505, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:15124018, ECO:0000269|PubMed:17075861, ECO:0000269|PubMed:20823453, ECO:0000305|PubMed:30995492}.		acute-phase response [GO:0006953]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; endocrine pancreas development [GO:0031018]; germinal center B cell differentiation [GO:0002314]; glucagon secretion [GO:0070091]; glucose homeostasis [GO:0042593]; hepatic immune response [GO:0002384]; hepatocyte proliferation [GO:0072574]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; inflammatory response to wounding [GO:0090594]; interleukin-6-mediated signaling pathway [GO:0070102]; liver regeneration [GO:0097421]; maintenance of blood-brain barrier [GO:0035633]; monocyte chemotaxis [GO:0002548]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine production [GO:0032682]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of lipid storage [GO:0010888]; negative regulation of neurogenesis [GO:0050768]; negative regulation of primary miRNA processing [GO:2000635]; neuron cellular homeostasis [GO:0070050]; neuron projection development [GO:0031175]; neutrophil apoptotic process [GO:0001781]; neutrophil mediated immunity [GO:0002446]; platelet activation [GO:0030168]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell activation [GO:0050871]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-21 production [GO:0032745]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of angiogenesis [GO:0045765]; regulation of astrocyte activation [GO:0061888]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of microglial cell activation [GO:1903978]; regulation of neuroinflammatory response [GO:0150077]; regulation of vascular endothelial growth factor production [GO:0010574]; response to activity [GO:0014823]; response to glucocorticoid [GO:0051384]; response to peptidoglycan [GO:0032494]; T follicular helper cell differentiation [GO:0061470]; T-helper 17 cell lineage commitment [GO:0072540]; vascular endothelial growth factor production [GO:0010573]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-6 receptor binding [GO:0005138]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-6 receptor binding [GO:0005138]; acute-phase response [GO:0006953]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; endocrine pancreas development [GO:0031018]; germinal center B cell differentiation [GO:0002314]; glucagon secretion [GO:0070091]; glucose homeostasis [GO:0042593]; hepatic immune response [GO:0002384]; hepatocyte proliferation [GO:0072574]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; inflammatory response to wounding [GO:0090594]; interleukin-6-mediated signaling pathway [GO:0070102]; liver regeneration [GO:0097421]; maintenance of blood-brain barrier [GO:0035633]; monocyte chemotaxis [GO:0002548]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine production [GO:0032682]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of lipid storage [GO:0010888]; negative regulation of neurogenesis [GO:0050768]; negative regulation of primary miRNA processing [GO:2000635]; neuron cellular homeostasis [GO:0070050]; neuron projection development [GO:0031175]; neutrophil apoptotic process [GO:0001781]; neutrophil mediated immunity [GO:0002446]; platelet activation [GO:0030168]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell activation [GO:0050871]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-21 production [GO:0032745]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of angiogenesis [GO:0045765]; regulation of astrocyte activation [GO:0061888]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of microglial cell activation [GO:1903978]; regulation of neuroinflammatory response [GO:0150077]; regulation of vascular endothelial growth factor production [GO:0010574]; response to activity [GO:0014823]; response to glucocorticoid [GO:0051384]; response to peptidoglycan [GO:0032494]; T follicular helper cell differentiation [GO:0061470]; T-helper 17 cell lineage commitment [GO:0072540]; vascular endothelial growth factor production [GO:0010573]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11080265}.
P05305	reviewed	EDN1_HUMAN	Endothelin-1 (Preproendothelin-1) (PPET1) [Cleaved into: Endothelin-1 (ET-1); Big endothelin-1]	EDN1	Homo sapiens (Human)	212	FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). {ECO:0000250|UniProtKB:P09558, ECO:0000269|PubMed:17446437, ECO:0000269|PubMed:19086031}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; artery smooth muscle contraction [GO:0014824]; axon extension [GO:0048675]; axonogenesis involved in innervation [GO:0060385]; body fluid secretion [GO:0007589]; branching involved in blood vessel morphogenesis [GO:0001569]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; canonical NF-kappaB signal transduction [GO:0007249]; canonical Wnt signaling pathway [GO:0060070]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cartilage development [GO:0051216]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to calcium ion [GO:0071277]; cellular response to fatty acid [GO:0071398]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to human chorionic gonadotropin stimulus [GO:0044751]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to mineralocorticoid stimulus [GO:0071389]; cellular response to organic substance [GO:0071310]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cellular response to xenobiotic stimulus [GO:0071466]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube development [GO:0035050]; endothelin receptor signaling pathway [GO:0086100]; endothelin receptor signaling pathway involved in heart process [GO:0086101]; epithelial fluid transport [GO:0042045]; ERK1 and ERK2 cascade [GO:0070371]; G protein-coupled receptor signaling pathway [GO:0007186]; histamine secretion [GO:0001821]; in utero embryonic development [GO:0001701]; inositol phosphate-mediated signaling [GO:0048016]; intracellular calcium ion homeostasis [GO:0006874]; leukocyte activation [GO:0045321]; maternal process involved in parturition [GO:0060137]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; membrane depolarization [GO:0051899]; middle ear morphogenesis [GO:0042474]; mitochondrion organization [GO:0007005]; negative regulation of blood coagulation [GO:0030195]; negative regulation of gene expression [GO:0010629]; negative regulation of hormone secretion [GO:0046888]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell fate commitment [GO:0014034]; nitric oxide transport [GO:0030185]; noradrenergic neuron differentiation [GO:0003357]; peptide hormone secretion [GO:0030072]; pharyngeal arch artery morphogenesis [GO:0061626]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phospholipase D-activating G protein-coupled receptor signaling pathway [GO:0031583]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell size [GO:0045793]; positive regulation of chemokine-mediated signaling pathway [GO:0070101]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of heart rate [GO:0010460]; positive regulation of hormone secretion [GO:0046887]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of odontogenesis [GO:0042482]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of prostaglandin-endoperoxide synthase activity [GO:0060585]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of urine volume [GO:0035810]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostaglandin biosynthetic process [GO:0001516]; protein kinase A signaling [GO:0010737]; protein kinase C deactivation [GO:0042313]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of glucose transmembrane transport [GO:0010827]; regulation of pH [GO:0006885]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; renal sodium ion absorption [GO:0070294]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to activity [GO:0014823]; response to amino acid [GO:0043200]; response to amphetamine [GO:0001975]; response to dexamethasone [GO:0071548]; response to leptin [GO:0044321]; response to lipopolysaccharide [GO:0032496]; response to muscle stretch [GO:0035994]; response to nicotine [GO:0035094]; response to ozone [GO:0010193]; response to prostaglandin F [GO:0034696]; response to testosterone [GO:0033574]; rhythmic excitation [GO:0043179]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; superoxide anion generation [GO:0042554]; sympathetic neuron axon guidance [GO:0097492]; thyroid gland development [GO:0030878]; transcription by RNA polymerase II [GO:0006366]; vasoconstriction [GO:0042310]; vein smooth muscle contraction [GO:0014826]	basal part of cell [GO:0045178]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; rough endoplasmic reticulum lumen [GO:0048237]; transport vesicle [GO:0030133]; Weibel-Palade body [GO:0033093]	cytokine activity [GO:0005125]; endothelin A receptor binding [GO:0031707]; endothelin B receptor binding [GO:0031708]; hormone activity [GO:0005179]	basal part of cell [GO:0045178]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; rough endoplasmic reticulum lumen [GO:0048237]; transport vesicle [GO:0030133]; Weibel-Palade body [GO:0033093]; cytokine activity [GO:0005125]; endothelin A receptor binding [GO:0031707]; endothelin B receptor binding [GO:0031708]; hormone activity [GO:0005179]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; artery smooth muscle contraction [GO:0014824]; axon extension [GO:0048675]; axonogenesis involved in innervation [GO:0060385]; body fluid secretion [GO:0007589]; branching involved in blood vessel morphogenesis [GO:0001569]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; canonical NF-kappaB signal transduction [GO:0007249]; canonical Wnt signaling pathway [GO:0060070]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cartilage development [GO:0051216]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to calcium ion [GO:0071277]; cellular response to fatty acid [GO:0071398]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to human chorionic gonadotropin stimulus [GO:0044751]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to mineralocorticoid stimulus [GO:0071389]; cellular response to organic substance [GO:0071310]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cellular response to xenobiotic stimulus [GO:0071466]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube development [GO:0035050]; endothelin receptor signaling pathway [GO:0086100]; endothelin receptor signaling pathway involved in heart process [GO:0086101]; epithelial fluid transport [GO:0042045]; ERK1 and ERK2 cascade [GO:0070371]; G protein-coupled receptor signaling pathway [GO:0007186]; histamine secretion [GO:0001821]; in utero embryonic development [GO:0001701]; inositol phosphate-mediated signaling [GO:0048016]; intracellular calcium ion homeostasis [GO:0006874]; leukocyte activation [GO:0045321]; maternal process involved in parturition [GO:0060137]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; membrane depolarization [GO:0051899]; middle ear morphogenesis [GO:0042474]; mitochondrion organization [GO:0007005]; negative regulation of blood coagulation [GO:0030195]; negative regulation of gene expression [GO:0010629]; negative regulation of hormone secretion [GO:0046888]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell fate commitment [GO:0014034]; nitric oxide transport [GO:0030185]; noradrenergic neuron differentiation [GO:0003357]; peptide hormone secretion [GO:0030072]; pharyngeal arch artery morphogenesis [GO:0061626]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phospholipase D-activating G protein-coupled receptor signaling pathway [GO:0031583]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell size [GO:0045793]; positive regulation of chemokine-mediated signaling pathway [GO:0070101]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of heart rate [GO:0010460]; positive regulation of hormone secretion [GO:0046887]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of odontogenesis [GO:0042482]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of prostaglandin-endoperoxide synthase activity [GO:0060585]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of urine volume [GO:0035810]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostaglandin biosynthetic process [GO:0001516]; protein kinase A signaling [GO:0010737]; protein kinase C deactivation [GO:0042313]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of glucose transmembrane transport [GO:0010827]; regulation of pH [GO:0006885]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; renal sodium ion absorption [GO:0070294]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to activity [GO:0014823]; response to amino acid [GO:0043200]; response to amphetamine [GO:0001975]; response to dexamethasone [GO:0071548]; response to leptin [GO:0044321]; response to lipopolysaccharide [GO:0032496]; response to muscle stretch [GO:0035994]; response to nicotine [GO:0035094]; response to ozone [GO:0010193]; response to prostaglandin F [GO:0034696]; response to testosterone [GO:0033574]; rhythmic excitation [GO:0043179]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; superoxide anion generation [GO:0042554]; sympathetic neuron axon guidance [GO:0097492]; thyroid gland development [GO:0030878]; transcription by RNA polymerase II [GO:0006366]; vasoconstriction [GO:0042310]; vein smooth muscle contraction [GO:0014826]	SUBCELLULAR LOCATION: Secreted.
P05362	reviewed	ICAM1_HUMAN	Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)	ICAM1	Homo sapiens (Human)	532	FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742}.; FUNCTION: (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}.; FUNCTION: (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. {ECO:0000269|PubMed:11413168}.		adhesion of symbiont to host [GO:0044406]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cellular response to amyloid-beta [GO:1904646]; cellular response to glucose stimulus [GO:0071333]; cellular response to leukemia inhibitory factor [GO:1990830]; establishment of endothelial barrier [GO:0061028]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; membrane to membrane docking [GO:0022614]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; receptor-mediated virion attachment to host cell [GO:0046813]; regulation of leukocyte mediated cytotoxicity [GO:0001910]; regulation of ruffle assembly [GO:1900027]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]; T cell antigen processing and presentation [GO:0002457]; T cell extravasation [GO:0072683]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]; adhesion of symbiont to host [GO:0044406]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cellular response to amyloid-beta [GO:1904646]; cellular response to glucose stimulus [GO:0071333]; cellular response to leukemia inhibitory factor [GO:1990830]; establishment of endothelial barrier [GO:0061028]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; membrane to membrane docking [GO:0022614]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; receptor-mediated virion attachment to host cell [GO:0046813]; regulation of leukocyte mediated cytotoxicity [GO:0001910]; regulation of ruffle assembly [GO:1900027]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]; T cell antigen processing and presentation [GO:0002457]; T cell extravasation [GO:0072683]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P05386	reviewed	RLA1_HUMAN	Large ribosomal subunit protein P1 (60S acidic ribosomal protein P1)	RPLP1 RRP1	Homo sapiens (Human)	114	FUNCTION: Plays an important role in the elongation step of protein synthesis.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]; translational elongation [GO:0006414]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]	protein kinase activator activity [GO:0030295]; ribonucleoprotein complex binding [GO:0043021]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; protein kinase activator activity [GO:0030295]; ribonucleoprotein complex binding [GO:0043021]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]; translational elongation [GO:0006414]	
P05387	reviewed	RLA2_HUMAN	Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44)	RPLP2 D11S2243E RPP2	Homo sapiens (Human)	115	FUNCTION: Plays an important role in the elongation step of protein synthesis.		cytoplasmic translation [GO:0002181]; cytoplasmic translational elongation [GO:0002182]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; cytoplasmic translational elongation [GO:0002182]; translation [GO:0006412]	
P05388	reviewed	RLA0_HUMAN	Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (60S ribosomal protein L10E)	RPLP0	Homo sapiens (Human)	317	FUNCTION: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.		cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]	large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19188445}. Cytoplasm {ECO:0000269|PubMed:19188445}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:19188445, PubMed:17289661). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:19188445}.
P05408	reviewed	7B2_HUMAN	Neuroendocrine protein 7B2 (Pituitary polypeptide) (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide]	SCG5 SGNE1	Homo sapiens (Human)	212	FUNCTION: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. {ECO:0000269|PubMed:7913882}.		intracellular protein transport [GO:0006886]; neuropeptide signaling pathway [GO:0007218]; peptide hormone processing [GO:0016486]; regulation of hormone secretion [GO:0046883]	extracellular region [GO:0005576]; nucleus [GO:0005634]; secretory granule [GO:0030141]	enzyme inhibitor activity [GO:0004857]; enzyme regulator activity [GO:0030234]; GTP binding [GO:0005525]; unfolded protein binding [GO:0051082]	extracellular region [GO:0005576]; nucleus [GO:0005634]; secretory granule [GO:0030141]; enzyme inhibitor activity [GO:0004857]; enzyme regulator activity [GO:0030234]; GTP binding [GO:0005525]; unfolded protein binding [GO:0051082]; intracellular protein transport [GO:0006886]; neuropeptide signaling pathway [GO:0007218]; peptide hormone processing [GO:0016486]; regulation of hormone secretion [GO:0046883]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01165}. Note=Neuroendocrine and endocrine secretory granules. {ECO:0000250|UniProtKB:P01165}.
P05412	reviewed	JUN_HUMAN	Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)	JUN	Homo sapiens (Human)	331	FUNCTION: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000250|UniProtKB:P05627, ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}.; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. {ECO:0000269|PubMed:31341047}.		cellular response to cadmium ion [GO:0071276]; cellular response to reactive oxygen species [GO:0034614]; integrated stress response signaling [GO:0140467]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990441]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; release from viral latency [GO:0019046]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]	chromatin [GO:0000785]; euchromatin [GO:0000791]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667]	cAMP response element binding [GO:0035497]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; general transcription initiation factor binding [GO:0140296]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]	chromatin [GO:0000785]; euchromatin [GO:0000791]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667]; cAMP response element binding [GO:0035497]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; general transcription initiation factor binding [GO:0140296]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]; cellular response to cadmium ion [GO:0071276]; cellular response to reactive oxygen species [GO:0034614]; integrated stress response signaling [GO:0140467]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990441]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; release from viral latency [GO:0019046]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Nucleus.
P05413	reviewed	FABPH_HUMAN	Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) (Mammary-derived growth inhibitor) (MDGI) (Muscle fatty acid-binding protein) (M-FABP)	FABP3 FABP11 MDGI	Homo sapiens (Human)	133	FUNCTION: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.		brown fat cell differentiation [GO:0050873]; cholesterol homeostasis [GO:0042632]; intracellular lipid transport [GO:0032365]; long-chain fatty acid transport [GO:0015909]; negative regulation of cell population proliferation [GO:0008285]; phospholipid homeostasis [GO:0055091]; positive regulation of long-chain fatty acid import into cell [GO:0140214]; positive regulation of phospholipid biosynthetic process [GO:0071073]; regulation of fatty acid oxidation [GO:0046320]; regulation of phosphatidylcholine biosynthetic process [GO:2001245]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]	cytoskeletal protein binding [GO:0008092]; long-chain fatty acid binding [GO:0036041]; oleic acid binding [GO:0070538]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]; cytoskeletal protein binding [GO:0008092]; long-chain fatty acid binding [GO:0036041]; oleic acid binding [GO:0070538]; brown fat cell differentiation [GO:0050873]; cholesterol homeostasis [GO:0042632]; intracellular lipid transport [GO:0032365]; long-chain fatty acid transport [GO:0015909]; negative regulation of cell population proliferation [GO:0008285]; phospholipid homeostasis [GO:0055091]; positive regulation of long-chain fatty acid import into cell [GO:0140214]; positive regulation of phospholipid biosynthetic process [GO:0071073]; regulation of fatty acid oxidation [GO:0046320]; regulation of phosphatidylcholine biosynthetic process [GO:2001245]	SUBCELLULAR LOCATION: Cytoplasm.
P05423	reviewed	RPC4_HUMAN	DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog)	POLR3D BN51 BN51T	Homo sapiens (Human)	398	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; tRNA transcription by RNA polymerase III [GO:0042797]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; tRNA transcription by RNA polymerase III [GO:0042797]	SUBCELLULAR LOCATION: Nucleus.
P05451	reviewed	REG1A_HUMAN	Lithostathine-1-alpha (Islet cells regeneration factor) (ICRF) (Islet of Langerhans regenerating protein) (REG) (Pancreatic stone protein) (PSP) (Pancreatic thread protein) (PTP) (Regenerating islet-derived protein 1-alpha) (REG-1-alpha) (Regenerating protein I alpha)	REG1A PSPS PSPS1 REG	Homo sapiens (Human)	166	FUNCTION: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell wall disruption in another organism [GO:0044278]; positive regulation of cell population proliferation [GO:0008284]; response to peptide hormone [GO:0043434]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	growth factor activity [GO:0008083]; molecular function inhibitor activity [GO:0140678]; oligosaccharide binding [GO:0070492]; peptidoglycan binding [GO:0042834]; signaling receptor activity [GO:0038023]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; growth factor activity [GO:0008083]; molecular function inhibitor activity [GO:0140678]; oligosaccharide binding [GO:0070492]; peptidoglycan binding [GO:0042834]; signaling receptor activity [GO:0038023]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell wall disruption in another organism [GO:0044278]; positive regulation of cell population proliferation [GO:0008284]; response to peptide hormone [GO:0043434]	SUBCELLULAR LOCATION: Secreted.
P05452	reviewed	TETN_HUMAN	Tetranectin (TN) (C-type lectin domain family 3 member B) (Plasminogen kringle 4-binding protein)	CLEC3B TNA	Homo sapiens (Human)	202	FUNCTION: Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. Plays a role in retinal function (PubMed:35331648). {ECO:0000269|PubMed:35331648}.		bone mineralization [GO:0030282]; cellular response to organic substance [GO:0071310]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ossification [GO:0001503]; positive regulation of plasminogen activation [GO:0010756]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; granular component [GO:0001652]; platelet dense granule lumen [GO:0031089]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; heparin binding [GO:0008201]; kringle domain binding [GO:0036143]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; granular component [GO:0001652]; platelet dense granule lumen [GO:0031089]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; heparin binding [GO:0008201]; kringle domain binding [GO:0036143]; bone mineralization [GO:0030282]; cellular response to organic substance [GO:0071310]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ossification [GO:0001503]; positive regulation of plasminogen activation [GO:0010756]	SUBCELLULAR LOCATION: Secreted.
P05455	reviewed	LA_HUMAN	Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B)	SSB	Homo sapiens (Human)	408	FUNCTION: Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}.	MISCELLANEOUS: Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.	histone mRNA metabolic process [GO:0008334]; IRES-dependent viral translational initiation [GO:0075522]; nuclear histone mRNA catabolic process [GO:0071045]; positive regulation of translation [GO:0045727]; protein localization to cytoplasmic stress granule [GO:1903608]; tRNA 3'-end processing [GO:0042780]; tRNA 5'-leader removal [GO:0001682]; tRNA export from nucleus [GO:0006409]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA binding [GO:0003729]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; tRNA binding [GO:0000049]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA binding [GO:0003729]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; tRNA binding [GO:0000049]; histone mRNA metabolic process [GO:0008334]; IRES-dependent viral translational initiation [GO:0075522]; nuclear histone mRNA catabolic process [GO:0071045]; positive regulation of translation [GO:0045727]; protein localization to cytoplasmic stress granule [GO:1903608]; tRNA 3'-end processing [GO:0042780]; tRNA 5'-leader removal [GO:0001682]; tRNA export from nucleus [GO:0006409]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P05496	reviewed	AT5G1_HUMAN	ATP synthase F(0) complex subunit C1, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase membrane subunit c locus 1) (ATP synthase proteolipid P1) (ATP synthase proton-transporting mitochondrial F(0) complex subunit C1) (ATPase protein 9) (ATPase subunit c)	ATP5MC1 ATP5G1	Homo sapiens (Human)	136	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.	MISCELLANEOUS: There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).	proton motive force-driven ATP synthesis [GO:0015986]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]	lipid binding [GO:0008289]; proton transmembrane transporter activity [GO:0015078]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]; lipid binding [GO:0008289]; proton transmembrane transporter activity [GO:0015078]; proton motive force-driven ATP synthesis [GO:0015986]	SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane protein.
P05538	reviewed	DQB2_HUMAN	HLA class II histocompatibility antigen, DQ beta 2 chain (HLA class II histocompatibility antigen, DX beta chain) (MHC class II antigen DQB2)	HLA-DQB2 HLA-DXB	Homo sapiens (Human)	268	FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. {ECO:0000269|PubMed:22407913}.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]	MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Lysosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
P05543	reviewed	THBG_HUMAN	Thyroxine-binding globulin (Serpin A7) (T4-binding globulin)	SERPINA7 TBG	Homo sapiens (Human)	415	FUNCTION: Major thyroid hormone transport protein in serum.		thyroid hormone transport [GO:0070327]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; thyroid hormone transport [GO:0070327]	SUBCELLULAR LOCATION: Secreted.
P05546	reviewed	HEP2_HUMAN	Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1)	SERPIND1 HCF2	Homo sapiens (Human)	499	FUNCTION: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. {ECO:0000269|PubMed:1939083}.; FUNCTION: Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. {ECO:0000269|PubMed:1939083}.		blood coagulation [GO:0007596]; chemotaxis [GO:0006935]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	endopeptidase inhibitor activity [GO:0004866]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; endopeptidase inhibitor activity [GO:0004866]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]; blood coagulation [GO:0007596]; chemotaxis [GO:0006935]	
P05549	reviewed	AP2A_HUMAN	Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)	TFAP2A AP2TF TFAP2	Homo sapiens (Human)	437	FUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}.	MISCELLANEOUS: [Isoform 4]: May be an aberrantly processed form with no significant distribution in vivo. {ECO:0000305}.	anatomical structure development [GO:0048856]; bone morphogenesis [GO:0060349]; cellular response to iron ion [GO:0071281]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; eyelid development in camera-type eye [GO:0061029]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oculomotor nerve formation [GO:0021623]; optic cup structural organization [GO:0003409]; optic vesicle morphogenesis [GO:0003404]; positive regulation of bone mineralization [GO:0030501]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; retina layer formation [GO:0010842]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; trigeminal nerve development [GO:0021559]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; nuclear receptor corepressor activity [GO:0140536]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; nuclear receptor corepressor activity [GO:0140536]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure development [GO:0048856]; bone morphogenesis [GO:0060349]; cellular response to iron ion [GO:0071281]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; eyelid development in camera-type eye [GO:0061029]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oculomotor nerve formation [GO:0021623]; optic cup structural organization [GO:0003409]; optic vesicle morphogenesis [GO:0003404]; positive regulation of bone mineralization [GO:0030501]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; retina layer formation [GO:0010842]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; trigeminal nerve development [GO:0021559]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12586840}.
P05556	reviewed	ITB1_HUMAN	Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)	ITGB1 FNRB MDF2 MSK12	Homo sapiens (Human)	798	FUNCTION: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). {ECO:0000250|UniProtKB:P07228, ECO:0000250|UniProtKB:P09055, ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:33962943, ECO:0000269|PubMed:7523423}.; FUNCTION: [Isoform 2]: Interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). {ECO:0000305|PubMed:2249781}.; FUNCTION: [Isoform 5]: Isoform 5 displaces isoform 1 in striated muscles. {ECO:0000250|UniProtKB:P09055}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. {ECO:0000269|PubMed:8411387}.; FUNCTION: (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:20660204}.; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4. {ECO:0000269|PubMed:17945327}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19. {ECO:0000269|PubMed:12907437}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus. {ECO:0000269|PubMed:12941907}.; FUNCTION: (Microbial infection) Acts as a receptor for Mammalian reovirus. {ECO:0000269|PubMed:16501085}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.; FUNCTION: (Microbial infection) Interacts with CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:32487760). Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression (PubMed:32487760). {ECO:0000269|PubMed:32487760}.; FUNCTION: (Microbial infection) May serve as a receptor for adhesin A (nadA) of N.meningitidis. {ECO:0000305|PubMed:21471204}.		axon extension [GO:0048675]; B cell differentiation [GO:0030183]; basement membrane organization [GO:0071711]; calcium-independent cell-matrix adhesion [GO:0007161]; cardiac cell fate specification [GO:0060912]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; CD40 signaling pathway [GO:0023035]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell projection organization [GO:0030030]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cellular defense response [GO:0006968]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; dendrite morphogenesis [GO:0048813]; establishment of mitotic spindle orientation [GO:0000132]; formation of radial glial scaffolds [GO:0021943]; G1/S transition of mitotic cell cycle [GO:0000082]; germ cell migration [GO:0008354]; heterotypic cell-cell adhesion [GO:0034113]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; lamellipodium assembly [GO:0030032]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; maintenance of blood-brain barrier [GO:0035633]; mesodermal cell differentiation [GO:0048333]; muscle organ development [GO:0007517]; myoblast differentiation [GO:0045445]; myoblast fate specification [GO:0048626]; myoblast fusion [GO:0007520]; negative regulation of anoikis [GO:2000811]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of Rho protein signal transduction [GO:0035024]; neuroblast proliferation [GO:0007405]; phagocytosis [GO:0006909]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051951]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of wound healing [GO:0090303]; reactive gliosis [GO:0150103]; receptor internalization [GO:0031623]; regulation of cell cycle [GO:0051726]; regulation of collagen catabolic process [GO:0010710]; regulation of inward rectifier potassium channel activity [GO:1901979]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synapse pruning [GO:1905806]; sarcomere organization [GO:0045214]; visual learning [GO:0008542]; wound healing, spreading of epidermal cells [GO:0035313]	cell surface [GO:0009986]; cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glial cell projection [GO:0097386]; integrin alpha1-beta1 complex [GO:0034665]; integrin alpha10-beta1 complex [GO:0034680]; integrin alpha11-beta1 complex [GO:0034681]; integrin alpha2-beta1 complex [GO:0034666]; integrin alpha3-beta1 complex [GO:0034667]; integrin alpha4-beta1 complex [GO:0034668]; integrin alpha5-beta1 complex [GO:0034674]; integrin alpha7-beta1 complex [GO:0034677]; integrin alpha8-beta1 complex [GO:0034678]; integrin complex [GO:0008305]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; myelin sheath abaxonal region [GO:0035748]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; recycling endosome [GO:0055037]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]	actin binding [GO:0003779]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; collagen binding involved in cell-matrix adhesion [GO:0098639]; coreceptor activity [GO:0015026]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glial cell projection [GO:0097386]; integrin alpha1-beta1 complex [GO:0034665]; integrin alpha10-beta1 complex [GO:0034680]; integrin alpha11-beta1 complex [GO:0034681]; integrin alpha2-beta1 complex [GO:0034666]; integrin alpha3-beta1 complex [GO:0034667]; integrin alpha4-beta1 complex [GO:0034668]; integrin alpha5-beta1 complex [GO:0034674]; integrin alpha7-beta1 complex [GO:0034677]; integrin alpha8-beta1 complex [GO:0034678]; integrin complex [GO:0008305]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; myelin sheath abaxonal region [GO:0035748]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; recycling endosome [GO:0055037]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; collagen binding involved in cell-matrix adhesion [GO:0098639]; coreceptor activity [GO:0015026]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; virus receptor activity [GO:0001618]; axon extension [GO:0048675]; B cell differentiation [GO:0030183]; basement membrane organization [GO:0071711]; calcium-independent cell-matrix adhesion [GO:0007161]; cardiac cell fate specification [GO:0060912]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; CD40 signaling pathway [GO:0023035]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell projection organization [GO:0030030]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cellular defense response [GO:0006968]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; dendrite morphogenesis [GO:0048813]; establishment of mitotic spindle orientation [GO:0000132]; formation of radial glial scaffolds [GO:0021943]; G1/S transition of mitotic cell cycle [GO:0000082]; germ cell migration [GO:0008354]; heterotypic cell-cell adhesion [GO:0034113]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; lamellipodium assembly [GO:0030032]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; maintenance of blood-brain barrier [GO:0035633]; mesodermal cell differentiation [GO:0048333]; muscle organ development [GO:0007517]; myoblast differentiation [GO:0045445]; myoblast fate specification [GO:0048626]; myoblast fusion [GO:0007520]; negative regulation of anoikis [GO:2000811]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of Rho protein signal transduction [GO:0035024]; neuroblast proliferation [GO:0007405]; phagocytosis [GO:0006909]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051951]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of wound healing [GO:0090303]; reactive gliosis [GO:0150103]; receptor internalization [GO:0031623]; regulation of cell cycle [GO:0051726]; regulation of collagen catabolic process [GO:0010710]; regulation of inward rectifier potassium channel activity [GO:1901979]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synapse pruning [GO:1905806]; sarcomere organization [GO:0045214]; visual learning [GO:0008542]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:32487760, ECO:0000269|PubMed:35687021, ECO:0000303|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:11919189}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome {ECO:0000269|PubMed:16256741}. Melanosome {ECO:0000269|PubMed:17081065}. Cleavage furrow {ECO:0000269|PubMed:17956333}. Cell projection, lamellipodium {ECO:0000269|PubMed:11919189}. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:35687021}. Note=Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. {ECO:0000269|PubMed:10455171}.; SUBCELLULAR LOCATION: [Isoform 2]: Note=Does not localize to focal adhesions. {ECO:0000269|PubMed:10455171}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P09055}. Cell junction {ECO:0000250|UniProtKB:P09055}. Note=In cardiac muscle, isoform 5 is found in costameres and intercalated disks. {ECO:0000250|UniProtKB:P09055}.
P05771	reviewed	KPCB_HUMAN	Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)	PRKCB PKCB PRKCB1	Homo sapiens (Human)	671	FUNCTION: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116}.		adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell activation [GO:0042113]; B cell receptor signaling pathway [GO:0050853]; calcium ion transport [GO:0006816]; cellular response to carbohydrate stimulus [GO:0071322]; dibenzo-p-dioxin metabolic process [GO:0018894]; intracellular calcium ion homeostasis [GO:0006874]; intracellular signal transduction [GO:0035556]; lipoprotein transport [GO:0042953]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of glucose transmembrane transport [GO:0010829]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of insulin secretion [GO:0032024]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of odontogenesis of dentin-containing tooth [GO:0042488]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; post-translational protein modification [GO:0043687]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein phosphorylation [GO:0006468]; regulation of dopamine secretion [GO:0014059]; regulation of glucose transmembrane transport [GO:0010827]; regulation of growth [GO:0040008]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to vitamin D [GO:0033280]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]	brush border membrane [GO:0031526]; calyx of Held [GO:0044305]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynaptic cytosol [GO:0099523]; spectrin [GO:0008091]	ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; calcium-dependent protein kinase C activity [GO:0004698]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H3T6 kinase activity [GO:0035403]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; protein kinase C activity [GO:0004697]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]	brush border membrane [GO:0031526]; calyx of Held [GO:0044305]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynaptic cytosol [GO:0099523]; spectrin [GO:0008091]; ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; calcium-dependent protein kinase C activity [GO:0004698]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H3T6 kinase activity [GO:0035403]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; protein kinase C activity [GO:0004697]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell activation [GO:0042113]; B cell receptor signaling pathway [GO:0050853]; calcium ion transport [GO:0006816]; cellular response to carbohydrate stimulus [GO:0071322]; dibenzo-p-dioxin metabolic process [GO:0018894]; intracellular calcium ion homeostasis [GO:0006874]; intracellular signal transduction [GO:0035556]; lipoprotein transport [GO:0042953]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of glucose transmembrane transport [GO:0010829]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of insulin secretion [GO:0032024]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of odontogenesis of dentin-containing tooth [GO:0042488]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; post-translational protein modification [GO:0043687]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein phosphorylation [GO:0006468]; regulation of dopamine secretion [GO:0014059]; regulation of glucose transmembrane transport [GO:0010827]; regulation of growth [GO:0040008]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to vitamin D [GO:0033280]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20228790}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
P05783	reviewed	K1C18_HUMAN	Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)	KRT18 CYK18 PIG46	Homo sapiens (Human)	430	FUNCTION: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	anatomical structure morphogenesis [GO:0009653]; cell cycle [GO:0007049]; extrinsic apoptotic signaling pathway [GO:0097191]; Golgi to plasma membrane protein transport [GO:0043001]; hepatocyte apoptotic process [GO:0097284]; intermediate filament cytoskeleton organization [GO:0045104]; negative regulation of apoptotic process [GO:0043066]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	adherens junction [GO:0005912]; cell periphery [GO:0071944]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; microtubule organizing center [GO:0005815]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]	cadherin binding involved in cell-cell adhesion [GO:0098641]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; structural molecule activity [GO:0005198]	adherens junction [GO:0005912]; cell periphery [GO:0071944]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; microtubule organizing center [GO:0005815]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]; cadherin binding involved in cell-cell adhesion [GO:0098641]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; structural molecule activity [GO:0005198]; anatomical structure morphogenesis [GO:0009653]; cell cycle [GO:0007049]; extrinsic apoptotic signaling pathway [GO:0097191]; Golgi to plasma membrane protein transport [GO:0043001]; hepatocyte apoptotic process [GO:0097284]; intermediate filament cytoskeleton organization [GO:0045104]; negative regulation of apoptotic process [GO:0043066]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250|UniProtKB:Q5BJY9}. Cytoplasm, perinuclear region. Nucleus, nucleolus {ECO:0000269|PubMed:22002106}. Cytoplasm {ECO:0000250|UniProtKB:Q5BJY9}.
P05787	reviewed	K2C8_HUMAN	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)	KRT8 CYK8	Homo sapiens (Human)	483	FUNCTION: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	cell differentiation involved in embryonic placenta development [GO:0060706]; extrinsic apoptotic signaling pathway [GO:0097191]; hepatocyte apoptotic process [GO:0097284]; response to hydrostatic pressure [GO:0051599]; response to other organism [GO:0051707]; sarcomere organization [GO:0045214]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	apicolateral plasma membrane [GO:0016327]; cell-cell junction [GO:0005911]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sarcolemma [GO:0042383]; Z disc [GO:0030018]	protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]	apicolateral plasma membrane [GO:0016327]; cell-cell junction [GO:0005911]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sarcolemma [GO:0042383]; Z disc [GO:0030018]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; cell differentiation involved in embryonic placenta development [GO:0060706]; extrinsic apoptotic signaling pathway [GO:0097191]; hepatocyte apoptotic process [GO:0097284]; response to hydrostatic pressure [GO:0051599]; response to other organism [GO:0051707]; sarcomere organization [GO:0045214]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10973561, ECO:0000269|PubMed:19188445}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q10758}. Nucleus matrix {ECO:0000250|UniProtKB:Q10758}.
P05813	reviewed	CRBA1_HUMAN	Beta-crystallin A3 [Cleaved into: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form]	CRYBA1 CRYB1	Homo sapiens (Human)	215	FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.		lens development in camera-type eye [GO:0002088]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; phagocytosis [GO:0006909]; positive regulation of anoikis [GO:2000210]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	structural constituent of eye lens [GO:0005212]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; structural constituent of eye lens [GO:0005212]; lens development in camera-type eye [GO:0002088]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; phagocytosis [GO:0006909]; positive regulation of anoikis [GO:2000210]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601]	
P05814	reviewed	CASB_HUMAN	Beta-casein	CSN2 CASB	Homo sapiens (Human)	226	FUNCTION: Important role in determination of the surface properties of the casein micelles.		calcium ion transport [GO:0006816]; lactation [GO:0007595]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; enzyme inhibitor activity [GO:0004857]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; enzyme inhibitor activity [GO:0004857]; calcium ion transport [GO:0006816]; lactation [GO:0007595]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]	SUBCELLULAR LOCATION: Secreted.
P05937	reviewed	CALB1_HUMAN	Calbindin (Calbindin D28) (D-28K) (Vitamin D-dependent calcium-binding protein, avian-type)	CALB1 CAB27	Homo sapiens (Human)	261	FUNCTION: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.		cellular response to organic substance [GO:0071310]; cochlea development [GO:0090102]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; metanephric collecting duct development [GO:0072205]; metanephric connecting tubule development [GO:0072286]; metanephric distal convoluted tubule development [GO:0072221]; metanephric part of ureteric bud development [GO:0035502]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; retina layer formation [GO:0010842]; short-term memory [GO:0007614]	axon [GO:0030424]; calyx of Held [GO:0044305]; cuticular plate [GO:0032437]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523]; stereocilium [GO:0032420]; synapse [GO:0045202]; terminal bouton [GO:0043195]	calcium ion binding [GO:0005509]; calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099567]; calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration [GO:0099534]; vitamin D binding [GO:0005499]; zinc ion binding [GO:0008270]	axon [GO:0030424]; calyx of Held [GO:0044305]; cuticular plate [GO:0032437]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523]; stereocilium [GO:0032420]; synapse [GO:0045202]; terminal bouton [GO:0043195]; calcium ion binding [GO:0005509]; calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099567]; calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration [GO:0099534]; vitamin D binding [GO:0005499]; zinc ion binding [GO:0008270]; cellular response to organic substance [GO:0071310]; cochlea development [GO:0090102]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; metanephric collecting duct development [GO:0072205]; metanephric connecting tubule development [GO:0072286]; metanephric distal convoluted tubule development [GO:0072221]; metanephric part of ureteric bud development [GO:0035502]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; retina layer formation [GO:0010842]; short-term memory [GO:0007614]	
P05976	reviewed	MYL1_HUMAN	Myosin light chain 1/3, skeletal muscle isoform (MLC1/MLC3) (MLC1F/MLC3F) (Myosin light chain alkali 1/2) (Myosin light chain A1/A2)	MYL1	Homo sapiens (Human)	194	FUNCTION: Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. {ECO:0000269|PubMed:30215711}.		muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]	contractile fiber [GO:0043292]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]	calcium ion binding [GO:0005509]; structural constituent of muscle [GO:0008307]	contractile fiber [GO:0043292]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; calcium ion binding [GO:0005509]; structural constituent of muscle [GO:0008307]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]	
P05981	reviewed	HEPS_HUMAN	Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain]	HPN TMPRSS1	Homo sapiens (Human)	417	FUNCTION: Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890). {ECO:0000269|PubMed:15839837, ECO:0000269|PubMed:21875933, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:26673890, ECO:0000269|PubMed:8346233}.		basement membrane disassembly [GO:0034769]; cochlea morphogenesis [GO:0090103]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; pilomotor reflex [GO:0097195]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell growth [GO:0030307]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of plasminogen activation [GO:0010756]; positive regulation of thyroid hormone generation [GO:2000611]; potassium ion transmembrane transport [GO:0071805]; proteolysis [GO:0006508]; regulation of cell shape [GO:0008360]; response to thyroid hormone [GO:0097066]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236]; basement membrane disassembly [GO:0034769]; cochlea morphogenesis [GO:0090103]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; pilomotor reflex [GO:0097195]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell growth [GO:0030307]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of plasminogen activation [GO:0010756]; positive regulation of thyroid hormone generation [GO:2000611]; potassium ion transmembrane transport [GO:0071805]; proteolysis [GO:0006508]; regulation of cell shape [GO:0008360]; response to thyroid hormone [GO:0097066]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1885621}; Single-pass type II membrane protein {ECO:0000269|PubMed:1885621}. Apical cell membrane {ECO:0000269|PubMed:26673890}; Single-pass type II membrane protein {ECO:0000305}.
P05997	reviewed	CO5A2_HUMAN	Collagen alpha-2(V) chain	COL5A2	Homo sapiens (Human)	1499	FUNCTION: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). {ECO:0000250}.		cellular response to amino acid stimulus [GO:0071230]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; eye morphogenesis [GO:0048592]; negative regulation of endodermal cell differentiation [GO:1903225]; ossification [GO:0001503]; skeletal system development [GO:0001501]; skin development [GO:0043588]	collagen type V trimer [GO:0005588]; collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]; SMAD binding [GO:0046332]	collagen type V trimer [GO:0005588]; collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]; SMAD binding [GO:0046332]; cellular response to amino acid stimulus [GO:0071230]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; eye morphogenesis [GO:0048592]; negative regulation of endodermal cell differentiation [GO:1903225]; ossification [GO:0001503]; skeletal system development [GO:0001501]; skin development [GO:0043588]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
P06028	reviewed	GLPB_HUMAN	Glycophorin-B (PAS-3) (SS-active sialoglycoprotein) (Sialoglycoprotein delta) (CD antigen CD235b)	GYPB GPB	Homo sapiens (Human)	91	FUNCTION: Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. {ECO:0000269|PubMed:35835865}.			ankyrin-1 complex [GO:0170014]; plasma membrane [GO:0005886]		ankyrin-1 complex [GO:0170014]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P06126	reviewed	CD1A_HUMAN	T-cell surface glycoprotein CD1a (T-cell surface antigen T6/Leu-6) (hTa1 thymocyte antigen) (CD antigen CD1a)	CD1A	Homo sapiens (Human)	327	FUNCTION: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:11231314, ECO:0000269|PubMed:16272286, ECO:0000269|PubMed:18178838}.	MISCELLANEOUS: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.	adaptive immune response [GO:0002250]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipopeptide binding [GO:0071723]	endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipopeptide binding [GO:0071723]; adaptive immune response [GO:0002250]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11231314, ECO:0000269|PubMed:11600221, ECO:0000269|PubMed:18178838}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:18178838}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:11231314}; Single-pass type I membrane protein {ECO:0000255}. Note=Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838). {ECO:0000269|PubMed:11231314, ECO:0000269|PubMed:18178838}.
P06127	reviewed	CD5_HUMAN	T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5)	CD5 LEU1	Homo sapiens (Human)	495	FUNCTION: May act as a receptor in regulating T-cell proliferation.		apoptotic signaling pathway [GO:0097190]; cell recognition [GO:0008037]; T cell costimulation [GO:0031295]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; apoptotic signaling pathway [GO:0097190]; cell recognition [GO:0008037]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P06132	reviewed	DCUP_HUMAN	Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37)	UROD	Homo sapiens (Human)	367	FUNCTION: Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway (PubMed:14633982, PubMed:11069625, PubMed:21668429, PubMed:11719352, PubMed:18004775). Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme (PubMed:14633982, PubMed:11069625, PubMed:21668429, PubMed:11719352). In vitro also decarboxylates pentacarboxylate porphyrinogen I (PubMed:12071824). {ECO:0000269|PubMed:11069625, ECO:0000269|PubMed:11719352, ECO:0000269|PubMed:12071824, ECO:0000269|PubMed:14633982, ECO:0000269|PubMed:18004775, ECO:0000269|PubMed:21668429}.		heme biosynthetic process [GO:0006783]; porphyrin-containing compound catabolic process [GO:0006787]; porphyrin-containing compound metabolic process [GO:0006778]; protoporphyrinogen IX biosynthetic process [GO:0006782]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	uroporphyrinogen decarboxylase activity [GO:0004853]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; uroporphyrinogen decarboxylase activity [GO:0004853]; heme biosynthetic process [GO:0006783]; porphyrin-containing compound catabolic process [GO:0006787]; porphyrin-containing compound metabolic process [GO:0006778]; protoporphyrinogen IX biosynthetic process [GO:0006782]	SUBCELLULAR LOCATION: Cytoplasm.
P06133	reviewed	UD2B4_HUMAN	UDP-glucuronosyltransferase 2B4 (UDPGT 2B4) (UGT2B4) (EC 2.4.1.17) (HLUG25) (Hyodeoxycholic acid-specific UDPGT) (UDPGTh-1)	UGT2B4 UGT2B11	Homo sapiens (Human)	528	FUNCTION: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). {ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:23288867}.		cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]	endoplasmic reticulum membrane [GO:0005789]	glucuronosyltransferase activity [GO:0015020]	endoplasmic reticulum membrane [GO:0005789]; glucuronosyltransferase activity [GO:0015020]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:8333863}; Single-pass membrane protein {ECO:0000255}.
P06213	reviewed	INSR_HUMAN	Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]	INSR	Homo sapiens (Human)	1382	FUNCTION: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}.		activation of protein kinase activity [GO:0032147]; activation of protein kinase B activity [GO:0032148]; adrenal gland development [GO:0030325]; amyloid-beta clearance [GO:0097242]; carbohydrate metabolic process [GO:0005975]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; dendritic spine maintenance [GO:0097062]; epidermis development [GO:0008544]; exocrine pancreas development [GO:0031017]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; heart morphogenesis [GO:0003007]; insulin receptor signaling pathway [GO:0008286]; learning [GO:0007612]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; memory [GO:0007613]; neuron projection maintenance [GO:1990535]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of developmental growth [GO:0048639]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of glycolytic process [GO:0045821]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of meiotic cell cycle [GO:0051446]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of receptor internalization [GO:0002092]; positive regulation of respiratory burst [GO:0060267]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of female gonad development [GO:2000194]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; transport across blood-brain barrier [GO:0150104]; viral entry into host cell [GO:0046718]	axon [GO:0030424]; caveola [GO:0005901]; dendrite membrane [GO:0032590]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; insulin receptor complex [GO:0005899]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; cargo receptor activity [GO:0038024]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; insulin receptor activity [GO:0005009]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; insulin-like growth factor receptor binding [GO:0005159]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein domain specific binding [GO:0019904]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; PTB domain binding [GO:0051425]	axon [GO:0030424]; caveola [GO:0005901]; dendrite membrane [GO:0032590]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; insulin receptor complex [GO:0005899]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; cargo receptor activity [GO:0038024]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; insulin receptor activity [GO:0005009]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; insulin-like growth factor receptor binding [GO:0005159]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein domain specific binding [GO:0019904]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; PTB domain binding [GO:0051425]; activation of protein kinase activity [GO:0032147]; activation of protein kinase B activity [GO:0032148]; adrenal gland development [GO:0030325]; amyloid-beta clearance [GO:0097242]; carbohydrate metabolic process [GO:0005975]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; dendritic spine maintenance [GO:0097062]; epidermis development [GO:0008544]; exocrine pancreas development [GO:0031017]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; heart morphogenesis [GO:0003007]; insulin receptor signaling pathway [GO:0008286]; learning [GO:0007612]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; memory [GO:0007613]; neuron projection maintenance [GO:1990535]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of developmental growth [GO:0048639]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of glycolytic process [GO:0045821]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of meiotic cell cycle [GO:0051446]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of receptor internalization [GO:0002092]; positive regulation of respiratory burst [GO:0060267]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of female gonad development [GO:2000194]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; transport across blood-brain barrier [GO:0150104]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P15208}; Single-pass type I membrane protein {ECO:0000305}. Late endosome {ECO:0000250|UniProtKB:P15208}. Lysosome {ECO:0000250|UniProtKB:P15208}. Note=Binding of insulin to INSR induces internalization and lysosomal degradation of the receptor, a means for down-regulating this signaling pathway after stimulation. In the presence of SORL1, internalized INSR molecules are redirected back to the cell surface, thereby preventing their lysosomal catabolism and strengthening insulin signal reception. {ECO:0000250|UniProtKB:P15208}.
P06239	reviewed	LCK_HUMAN	Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)	LCK	Homo sapiens (Human)	509	FUNCTION: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; B cell receptor signaling pathway [GO:0050853]; Fc-gamma receptor signaling pathway [GO:0038094]; hemopoiesis [GO:0030097]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intracellular zinc ion homeostasis [GO:0006882]; leukocyte migration [GO:0050900]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of leukocyte cell-cell adhesion [GO:1903039]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein phosphorylation [GO:0006468]; regulation of lymphocyte activation [GO:0051249]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; T cell costimulation [GO:0031295]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; pericentriolar material [GO:0000242]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATPase binding [GO:0051117]; CD4 receptor binding [GO:0042609]; CD8 receptor binding [GO:0042610]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol 3-kinase binding [GO:0043548]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine kinase activity [GO:0004713]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; pericentriolar material [GO:0000242]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; CD4 receptor binding [GO:0042609]; CD8 receptor binding [GO:0042610]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol 3-kinase binding [GO:0043548]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine kinase activity [GO:0004713]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; B cell receptor signaling pathway [GO:0050853]; Fc-gamma receptor signaling pathway [GO:0038094]; hemopoiesis [GO:0030097]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intracellular zinc ion homeostasis [GO:0006882]; leukocyte migration [GO:0050900]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of leukocyte cell-cell adhesion [GO:1903039]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein phosphorylation [GO:0006468]; regulation of lymphocyte activation [GO:0051249]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; T cell costimulation [GO:0031295]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:22034844}; Lipid-anchor {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:22034844}; Cytoplasmic side {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:22034844}. Cytoplasm, cytosol {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:22034844}. Note=Present in lipid rafts in an inactive form. {ECO:0000269|PubMed:12218089}.
P06241	reviewed	FYN_HUMAN	Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)	FYN	Homo sapiens (Human)	537	FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789}.		activated T cell proliferation [GO:0050798]; adaptive immune response [GO:0002250]; axon guidance [GO:0007411]; calcium ion transport [GO:0006816]; canonical NF-kappaB signal transduction [GO:0007249]; cell differentiation [GO:0030154]; cellular response to amyloid-beta [GO:1904646]; cellular response to glycine [GO:1905430]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to L-glutamate [GO:1905232]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dendrite morphogenesis [GO:0048813]; dendritic spine maintenance [GO:0097062]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; feeding behavior [GO:0007631]; forebrain development [GO:0030900]; heart process [GO:0003015]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; leukocyte migration [GO:0050900]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine maintenance [GO:1902951]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; neuron migration [GO:0001764]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of calcium ion import across plasma membrane [GO:1905664]; regulation of cell shape [GO:0008360]; regulation of glutamate receptor signaling pathway [GO:1900449]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to amyloid-beta [GO:1904645]; response to ethanol [GO:0045471]; response to singlet oxygen [GO:0000304]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	actin filament [GO:0005884]; cell body [GO:0044297]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; glial cell projection [GO:0097386]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; Schaffer collateral - CA1 synapse [GO:0098685]	alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; growth factor receptor binding [GO:0070851]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; transmembrane transporter binding [GO:0044325]; type 5 metabotropic glutamate receptor binding [GO:0031802]	actin filament [GO:0005884]; cell body [GO:0044297]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; glial cell projection [GO:0097386]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; Schaffer collateral - CA1 synapse [GO:0098685]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; growth factor receptor binding [GO:0070851]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; transmembrane transporter binding [GO:0044325]; type 5 metabotropic glutamate receptor binding [GO:0031802]; activated T cell proliferation [GO:0050798]; adaptive immune response [GO:0002250]; axon guidance [GO:0007411]; calcium ion transport [GO:0006816]; canonical NF-kappaB signal transduction [GO:0007249]; cell differentiation [GO:0030154]; cellular response to amyloid-beta [GO:1904646]; cellular response to glycine [GO:1905430]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to L-glutamate [GO:1905232]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dendrite morphogenesis [GO:0048813]; dendritic spine maintenance [GO:0097062]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; feeding behavior [GO:0007631]; forebrain development [GO:0030900]; heart process [GO:0003015]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; leukocyte migration [GO:0050900]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine maintenance [GO:1902951]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; neuron migration [GO:0001764]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of calcium ion import across plasma membrane [GO:1905664]; regulation of cell shape [GO:0008360]; regulation of glutamate receptor signaling pathway [GO:1900449]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to amyloid-beta [GO:1904645]; response to ethanol [GO:0045471]; response to singlet oxygen [GO:0000304]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15537652, ECO:0000269|PubMed:8206991}. Nucleus {ECO:0000269|PubMed:15537652}. Cell membrane {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:8206991}. Perikaryon {ECO:0000250|UniProtKB:Q62844}. Note=Present and active in lipid rafts (PubMed:12218089). Palmitoylation is crucial for proper trafficking (PubMed:8206991). {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:8206991}.
P06276	reviewed	CHLE_HUMAN	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	BCHE CHE1	Homo sapiens (Human)	602	FUNCTION: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. {ECO:0000269|PubMed:19452557, ECO:0000269|PubMed:19542320}.		acetylcholine catabolic process [GO:0006581]; choline metabolic process [GO:0019695]; cocaine metabolic process [GO:0050783]; learning [GO:0007612]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of synaptic transmission [GO:0050805]; neuroblast differentiation [GO:0014016]; peptide hormone processing [GO:0016486]; response to alkaloid [GO:0043279]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384]; xenobiotic metabolic process [GO:0006805]	blood microparticle [GO:0072562]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nuclear envelope lumen [GO:0005641]; plasma membrane [GO:0005886]	acetylcholinesterase activity [GO:0003990]; amyloid-beta binding [GO:0001540]; catalytic activity [GO:0003824]; choline binding [GO:0033265]; cholinesterase activity [GO:0004104]; enzyme binding [GO:0019899]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]	blood microparticle [GO:0072562]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nuclear envelope lumen [GO:0005641]; plasma membrane [GO:0005886]; acetylcholinesterase activity [GO:0003990]; amyloid-beta binding [GO:0001540]; catalytic activity [GO:0003824]; choline binding [GO:0033265]; cholinesterase activity [GO:0004104]; enzyme binding [GO:0019899]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; acetylcholine catabolic process [GO:0006581]; choline metabolic process [GO:0019695]; cocaine metabolic process [GO:0050783]; learning [GO:0007612]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of synaptic transmission [GO:0050805]; neuroblast differentiation [GO:0014016]; peptide hormone processing [GO:0016486]; response to alkaloid [GO:0043279]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19368529, ECO:0000269|PubMed:19542320}.
P06280	reviewed	AGAL_HUMAN	Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Galactosylgalactosylglucosylceramidase GLA) (Melibiase) (Agalsidase)	GLA	Homo sapiens (Human)	429	FUNCTION: Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome. {ECO:0000269|PubMed:10838196, ECO:0000269|PubMed:8804427}.		glycoside catabolic process [GO:0016139]; glycosphingolipid catabolic process [GO:0046479]; glycosylceramide catabolic process [GO:0046477]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of nitric-oxide synthase activity [GO:0051001]; oligosaccharide metabolic process [GO:0009311]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	alpha-galactosidase activity [GO:0004557]; catalytic activity [GO:0003824]; galactoside binding [GO:0016936]; galactosylgalactosylglucosylceramidase activity [GO:0017041]; hydrolase activity [GO:0016787]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; alpha-galactosidase activity [GO:0004557]; catalytic activity [GO:0003824]; galactoside binding [GO:0016936]; galactosylgalactosylglucosylceramidase activity [GO:0017041]; hydrolase activity [GO:0016787]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; glycoside catabolic process [GO:0016139]; glycosphingolipid catabolic process [GO:0046479]; glycosylceramide catabolic process [GO:0046477]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of nitric-oxide synthase activity [GO:0051001]; oligosaccharide metabolic process [GO:0009311]	SUBCELLULAR LOCATION: Lysosome.
P06307	reviewed	CCKN_HUMAN	Cholecystokinin (CCK) [Cleaved into: Cholecystokinin-58 (CCK58); Cholecystokinin-58 desnonopeptide ((1-49)-CCK58); Cholecystokinin-39 (CCK39); Cholecystokinin-33 (CCK33); Cholecystokinin-25 (CCK25); Cholecystokinin-18 (CCK18); Cholecystokinin-12 (CCK12); Cholecystokinin-8 (CCK8); Cholecystokinin-7 (CCK7); Cholecystokinin-5 (CCK5)]	CCK	Homo sapiens (Human)	115	FUNCTION: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. {ECO:0000250|UniProtKB:Q9TS44}.		axonogenesis [GO:0007409]; digestion [GO:0007586]; eating behavior [GO:0042755]; neuron migration [GO:0001764]; signal transduction [GO:0007165]	axon [GO:0030424]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428]	axon [GO:0030424]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428]; axonogenesis [GO:0007409]; digestion [GO:0007586]; eating behavior [GO:0042755]; neuron migration [GO:0001764]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25326458}.
P06312	reviewed	KV401_HUMAN	Immunoglobulin kappa variable 4-1 (Ig kappa chain V-IV region B17) (Ig kappa chain V-IV region JI) (Ig kappa chain V-IV region Len) (Ig kappa chain V-IV region STH)	IGKV4-1	Homo sapiens (Human)	121	FUNCTION: V segment of the variable domain of immunoglobulins light chain that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P06340	reviewed	DOA_HUMAN	HLA class II histocompatibility antigen, DO alpha chain (MHC DN-alpha) (MHC DZ alpha) (MHC class II antigen DOA)	HLA-DOA HLA-DNA HLA-DZA	Homo sapiens (Human)	250	FUNCTION: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; negative regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002587]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; regulation of T cell differentiation [GO:0045580]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]	MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; negative regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002587]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; regulation of T cell differentiation [GO:0045580]	SUBCELLULAR LOCATION: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
P06396	reviewed	GELS_HUMAN	Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin)	GSN	Homo sapiens (Human)	782	FUNCTION: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (PubMed:19666512). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:19666512, ECO:0000269|PubMed:20393563}.		actin filament capping [GO:0051693]; actin filament depolymerization [GO:0030042]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; amyloid fibril formation [GO:1990000]; barbed-end actin filament capping [GO:0051016]; cardiac muscle cell contraction [GO:0086003]; cell projection assembly [GO:0030031]; cellular response to type II interferon [GO:0071346]; central nervous system development [GO:0007417]; cilium assembly [GO:0060271]; hepatocyte apoptotic process [GO:0097284]; negative regulation of viral entry into host cell [GO:0046597]; phagocytosis, engulfment [GO:0006911]; positive regulation of actin nucleation [GO:0051127]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte apoptotic process [GO:1902174]; positive regulation of protein processing in phagocytic vesicle [GO:1903923]; protein destabilization [GO:0031648]; regulation of establishment of T cell polarity [GO:1903903]; regulation of plasma membrane raft polarization [GO:1903906]; regulation of podosome assembly [GO:0071801]; regulation of receptor clustering [GO:1903909]; relaxation of cardiac muscle [GO:0055119]; renal protein absorption [GO:0097017]; response to muscle stretch [GO:0035994]; sequestering of actin monomers [GO:0042989]; striated muscle atrophy [GO:0014891]	actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; blood microparticle [GO:0072562]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; podosome [GO:0002102]; sarcoplasm [GO:0016528]; secretory granule lumen [GO:0034774]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; myosin II binding [GO:0045159]; phosphatidylinositol 3-kinase catalytic subunit binding [GO:0036313]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; blood microparticle [GO:0072562]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; podosome [GO:0002102]; sarcoplasm [GO:0016528]; secretory granule lumen [GO:0034774]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; myosin II binding [GO:0045159]; phosphatidylinositol 3-kinase catalytic subunit binding [GO:0036313]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; actin filament capping [GO:0051693]; actin filament depolymerization [GO:0030042]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; amyloid fibril formation [GO:1990000]; barbed-end actin filament capping [GO:0051016]; cardiac muscle cell contraction [GO:0086003]; cell projection assembly [GO:0030031]; cellular response to type II interferon [GO:0071346]; central nervous system development [GO:0007417]; cilium assembly [GO:0060271]; hepatocyte apoptotic process [GO:0097284]; negative regulation of viral entry into host cell [GO:0046597]; phagocytosis, engulfment [GO:0006911]; positive regulation of actin nucleation [GO:0051127]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte apoptotic process [GO:1902174]; positive regulation of protein processing in phagocytic vesicle [GO:1903923]; protein destabilization [GO:0031648]; regulation of establishment of T cell polarity [GO:1903903]; regulation of plasma membrane raft polarization [GO:1903906]; regulation of podosome assembly [GO:0071801]; regulation of receptor clustering [GO:1903909]; relaxation of cardiac muscle [GO:0055119]; renal protein absorption [GO:0097017]; response to muscle stretch [GO:0035994]; sequestering of actin monomers [GO:0042989]; striated muscle atrophy [GO:0014891]	SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton.; SUBCELLULAR LOCATION: [Isoform 1]: Secreted.
P06400	reviewed	RB_HUMAN	Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)	RB1	Homo sapiens (Human)	928	FUNCTION: Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}.		aortic valve morphogenesis [GO:0003180]; cell differentiation [GO:0030154]; cell division [GO:0051301]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to insulin stimulus [GO:0032869]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; chromatin remodeling [GO:0006338]; chromosome organization [GO:0051276]; digestive tract development [GO:0048565]; enucleate erythrocyte differentiation [GO:0043353]; epithelial cell proliferation [GO:0050673]; glial cell apoptotic process [GO:0034349]; glial cell proliferation [GO:0014009]; hepatocyte apoptotic process [GO:0097284]; heterochromatin formation [GO:0031507]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; myoblast differentiation [GO:0045445]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of inflammatory response [GO:0050728]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of tau-protein kinase activity [GO:1902948]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071930]; neuron apoptotic process [GO:0051402]; neuron maturation [GO:0042551]; neuron projection development [GO:0031175]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; protein localization to chromosome, centromeric region [GO:0071459]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of centromere complex assembly [GO:0090230]; regulation of DNA-templated transcription [GO:0006355]; regulation of lipid kinase activity [GO:0043550]; regulation of mitotic cell cycle [GO:0007346]; sister chromatid biorientation [GO:0031134]; skeletal muscle cell differentiation [GO:0035914]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]; striated muscle cell differentiation [GO:0051146]; tissue homeostasis [GO:0001894]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; chromatin lock complex [GO:0061793]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; Rb-E2F complex [GO:0035189]; spindle [GO:0005819]; SWI/SNF complex [GO:0016514]	disordered domain specific binding [GO:0097718]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; phosphoprotein binding [GO:0051219]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; chromatin lock complex [GO:0061793]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; Rb-E2F complex [GO:0035189]; spindle [GO:0005819]; SWI/SNF complex [GO:0016514]; disordered domain specific binding [GO:0097718]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; phosphoprotein binding [GO:0051219]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; aortic valve morphogenesis [GO:0003180]; cell differentiation [GO:0030154]; cell division [GO:0051301]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to insulin stimulus [GO:0032869]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; chromatin remodeling [GO:0006338]; chromosome organization [GO:0051276]; digestive tract development [GO:0048565]; enucleate erythrocyte differentiation [GO:0043353]; epithelial cell proliferation [GO:0050673]; glial cell apoptotic process [GO:0034349]; glial cell proliferation [GO:0014009]; hepatocyte apoptotic process [GO:0097284]; heterochromatin formation [GO:0031507]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; myoblast differentiation [GO:0045445]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of inflammatory response [GO:0050728]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of tau-protein kinase activity [GO:1902948]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071930]; neuron apoptotic process [GO:0051402]; neuron maturation [GO:0042551]; neuron projection development [GO:0031175]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; protein localization to chromosome, centromeric region [GO:0071459]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of centromere complex assembly [GO:0090230]; regulation of DNA-templated transcription [GO:0006355]; regulation of lipid kinase activity [GO:0043550]; regulation of mitotic cell cycle [GO:0007346]; sister chromatid biorientation [GO:0031134]; skeletal muscle cell differentiation [GO:0035914]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]; striated muscle cell differentiation [GO:0051146]; tissue homeostasis [GO:0001894]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20940255}. Note=During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. {ECO:0000269|PubMed:20940255}.
P06401	reviewed	PRGR_HUMAN	Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)	PGR NR3C3	Homo sapiens (Human)	933	FUNCTION: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.	MISCELLANEOUS: [Isoform B]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform A]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform B. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing of isoform B. {ECO:0000305}.	cell-cell signaling [GO:0007267]; glandular epithelial cell maturation [GO:0002071]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; lung alveolus development [GO:0048286]; negative regulation of gene expression [GO:0010629]; ovulation from ovarian follicle [GO:0001542]; paracrine signaling [GO:0038001]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; regulation of epithelial cell proliferation [GO:0050678]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ATPase binding [GO:0051117]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; nucleic acid binding [GO:0003676]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; signaling receptor binding [GO:0005102]; steroid binding [GO:0005496]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ATPase binding [GO:0051117]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; nucleic acid binding [GO:0003676]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; signaling receptor binding [GO:0005102]; steroid binding [GO:0005496]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]; cell-cell signaling [GO:0007267]; glandular epithelial cell maturation [GO:0002071]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; lung alveolus development [GO:0048286]; negative regulation of gene expression [GO:0010629]; ovulation from ovarian follicle [GO:0001542]; paracrine signaling [GO:0038001]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; regulation of epithelial cell proliferation [GO:0050678]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; SUBCELLULAR LOCATION: [Isoform A]: Nucleus. Cytoplasm. Note=Mainly nuclear.; SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion outer membrane {ECO:0000269|PubMed:23518922}.
P06454	reviewed	PTMA_HUMAN	Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]	PTMA TMSA	Homo sapiens (Human)	111	FUNCTION: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.		DNA-templated transcription [GO:0006351]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; ion binding [GO:0043167]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; ion binding [GO:0043167]; DNA-templated transcription [GO:0006351]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus.
P06493	reviewed	CDK1_HUMAN	Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)	CDK1 CDC2 CDC28A CDKN1 P34CDC2	Homo sapiens (Human)	297	FUNCTION: Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:17459720, PubMed:16933150, PubMed:18356527, PubMed:19509060, PubMed:20171170, PubMed:19917720, PubMed:20937773, PubMed:20935635, PubMed:21063390, PubMed:23355470, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:17459720, PubMed:16933150, PubMed:18356527, PubMed:19509060, PubMed:20171170, PubMed:19917720, PubMed:20937773, PubMed:20935635, PubMed:21063390, PubMed:23355470, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:32351706, PubMed:26829474, PubMed:30704899, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:34741373}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}.	MISCELLANEOUS: As a key regulator of the cell cycle, CDK1 is a potent therapeutic target for inhibitors in cancer treatment. {ECO:0000305|PubMed:21517772}.	animal organ regeneration [GO:0031100]; apoptotic process [GO:0006915]; cell division [GO:0051301]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to organic cyclic compound [GO:0071407]; centrosome cycle [GO:0007098]; chromosome condensation [GO:0030261]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; epithelial cell differentiation [GO:0030855]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast proliferation [GO:0048144]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; Golgi disassembly [GO:0090166]; microtubule cytoskeleton organization [GO:0000226]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of DNA replication [GO:0045740]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to nucleus [GO:1900182]; pronuclear fusion [GO:0007344]; protein localization to kinetochore [GO:0034501]; protein phosphorylation [GO:0006468]; protein-containing complex assembly [GO:0065003]; regulation of circadian rhythm [GO:0042752]; regulation of embryonic development [GO:0045995]; regulation of Schwann cell differentiation [GO:0014038]; response to activity [GO:0014823]; response to amine [GO:0014075]; response to axon injury [GO:0048678]; response to cadmium ion [GO:0046686]; response to copper ion [GO:0046688]; response to ethanol [GO:0045471]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; rhythmic process [GO:0048511]; ventricular cardiac muscle cell development [GO:0055015]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cyclin A2-CDK1 complex [GO:0097122]; cyclin B1-CDK1 complex [GO:0097125]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]	ATP binding [GO:0005524]; chromatin binding [GO:0003682]; cyclin binding [GO:0030332]; cyclin-dependent protein kinase activity [GO:0097472]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; histone kinase activity [GO:0035173]; Hsp70 protein binding [GO:0030544]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; virus receptor activity [GO:0001618]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cyclin A2-CDK1 complex [GO:0097122]; cyclin B1-CDK1 complex [GO:0097125]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; cyclin binding [GO:0030332]; cyclin-dependent protein kinase activity [GO:0097472]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; histone kinase activity [GO:0035173]; Hsp70 protein binding [GO:0030544]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; virus receptor activity [GO:0001618]; animal organ regeneration [GO:0031100]; apoptotic process [GO:0006915]; cell division [GO:0051301]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to organic cyclic compound [GO:0071407]; centrosome cycle [GO:0007098]; chromosome condensation [GO:0030261]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; epithelial cell differentiation [GO:0030855]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast proliferation [GO:0048144]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; Golgi disassembly [GO:0090166]; microtubule cytoskeleton organization [GO:0000226]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of DNA replication [GO:0045740]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to nucleus [GO:1900182]; pronuclear fusion [GO:0007344]; protein localization to kinetochore [GO:0034501]; protein phosphorylation [GO:0006468]; protein-containing complex assembly [GO:0065003]; regulation of circadian rhythm [GO:0042752]; regulation of embryonic development [GO:0045995]; regulation of Schwann cell differentiation [GO:0014038]; response to activity [GO:0014823]; response to amine [GO:0014075]; response to axon injury [GO:0048678]; response to cadmium ion [GO:0046686]; response to copper ion [GO:0046688]; response to ethanol [GO:0045471]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; rhythmic process [GO:0048511]; ventricular cardiac muscle cell development [GO:0055015]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P11440}. Cytoplasm {ECO:0000250|UniProtKB:P11440}. Mitochondrion {ECO:0000269|PubMed:19917720}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.
P06576	reviewed	ATPB_HUMAN	ATP synthase subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta)	ATP5F1B ATP5B ATPMB ATPSB	Homo sapiens (Human)	529	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. {ECO:0000269|PubMed:36239646}.		angiogenesis [GO:0001525]; ATP biosynthetic process [GO:0006754]; cellular response to interleukin-7 [GO:0098761]; generation of precursor metabolites and energy [GO:0006091]; lipid metabolic process [GO:0006629]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; osteoblast differentiation [GO:0001649]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600]; regulation of intracellular pH [GO:0051453]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, catalytic core [GO:0005754]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]	angiostatin binding [GO:0043532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; MHC class I protein binding [GO:0042288]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, catalytic core [GO:0005754]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; angiostatin binding [GO:0043532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; MHC class I protein binding [GO:0042288]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; angiogenesis [GO:0001525]; ATP biosynthetic process [GO:0006754]; cellular response to interleukin-7 [GO:0098761]; generation of precursor metabolites and energy [GO:0006091]; lipid metabolic process [GO:0006629]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; osteoblast differentiation [GO:0001649]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600]; regulation of intracellular pH [GO:0051453]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00829}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00829}; Matrix side {ECO:0000250|UniProtKB:P00829, ECO:0000269|PubMed:25168243}.
P06681	reviewed	CO2_HUMAN	Complement C2 (EC 3.4.21.43) (C3/C5 convertase) [Cleaved into: Complement C2b fragment; Complement C2a fragment]	C2	Homo sapiens (Human)	752	FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.	MISCELLANEOUS: C2 is a major histocompatibility complex class-III protein.	complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; positive regulation of apoptotic cell clearance [GO:2000427]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to thyroid hormone [GO:0097066]	classical-complement-pathway C3/C5 convertase complex [GO:0005601]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]	classical-complement-pathway C3/C5 convertase complex [GO:0005601]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; positive regulation of apoptotic cell clearance [GO:2000427]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to thyroid hormone [GO:0097066]	SUBCELLULAR LOCATION: Secreted.
P06702	reviewed	S10A9_HUMAN	Protein S100-A9 (Calgranulin-B) (Calprotectin L1H subunit) (Leukocyte L1 complex heavy chain) (Migration inhibitory factor-related protein 14) (MRP-14) (p14) (S100 calcium-binding protein A9)	S100A9 CAGB CFAG MRP14	Homo sapiens (Human)	114	FUNCTION: S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response (PubMed:12626582, PubMed:15331440, PubMed:20103766, PubMed:8423249, PubMed:16258195, PubMed:19122197, PubMed:21325622). It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism (PubMed:12626582, PubMed:15331440, PubMed:20103766). Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions (PubMed:8423249, PubMed:16258195, PubMed:19122197). The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase (PubMed:15331440, PubMed:21325622). Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX (PubMed:15642721, PubMed:22808130). The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities (PubMed:8423249, PubMed:19534726). Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration (PubMed:15598812, PubMed:21487906). Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER) (PubMed:19402754). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade (PubMed:19402754, PubMed:22804476). Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth (PubMed:19087201). Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3 (PubMed:19935772). Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK (PubMed:22363402). Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants (PubMed:22489132, PubMed:21912088). Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread (PubMed:16258195). Has transnitrosylase activity; in oxidatively-modified low-densitity lipoprotein (LDL(ox))-induced S-nitrosylation of GAPDH on 'Cys-247' proposed to transfer the NO moiety from NOS2/iNOS to GAPDH via its own S-nitrosylated Cys-3 (PubMed:25417112). The iNOS-S100A8/A9 transnitrosylase complex is proposed to also direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif (PubMed:25417112). {ECO:0000269|PubMed:12626582, ECO:0000269|PubMed:15331440, ECO:0000269|PubMed:15598812, ECO:0000269|PubMed:15642721, ECO:0000269|PubMed:16258195, ECO:0000269|PubMed:19087201, ECO:0000269|PubMed:19122197, ECO:0000269|PubMed:19402754, ECO:0000269|PubMed:19534726, ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:20103766, ECO:0000269|PubMed:21325622, ECO:0000269|PubMed:21487906, ECO:0000269|PubMed:22363402, ECO:0000269|PubMed:22804476, ECO:0000269|PubMed:22808130, ECO:0000269|PubMed:25417112, ECO:0000269|PubMed:8423249, ECO:0000303|PubMed:21912088, ECO:0000303|PubMed:22489132}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; apoptotic process [GO:0006915]; astrocyte development [GO:0014002]; autocrine signaling [GO:0035425]; autophagy [GO:0006914]; cell-cell signaling [GO:0007267]; chronic inflammatory response [GO:0002544]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; endothelial cell migration [GO:0043542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; leukocyte migration involved in inflammatory response [GO:0002523]; modulation of process of another organism [GO:0035821]; neutrophil aggregation [GO:0070488]; neutrophil chemotaxis [GO:0030593]; peptidyl-cysteine S-trans-nitrosylation [GO:0035606]; positive regulation of cell growth [GO:0030307]; positive regulation of inflammatory response [GO:0050729]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of cytoskeleton organization [GO:0051493]; regulation of integrin biosynthetic process [GO:0045113]; response to lipopolysaccharide [GO:0032496]; sequestering of zinc ion [GO:0032119]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]	antioxidant activity [GO:0016209]; arachidonic acid binding [GO:0050544]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; microtubule binding [GO:0008017]; RAGE receptor binding [GO:0050786]; Toll-like receptor 4 binding [GO:0035662]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; antioxidant activity [GO:0016209]; arachidonic acid binding [GO:0050544]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; microtubule binding [GO:0008017]; RAGE receptor binding [GO:0050786]; Toll-like receptor 4 binding [GO:0035662]; zinc ion binding [GO:0008270]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; apoptotic process [GO:0006915]; astrocyte development [GO:0014002]; autocrine signaling [GO:0035425]; autophagy [GO:0006914]; cell-cell signaling [GO:0007267]; chronic inflammatory response [GO:0002544]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; endothelial cell migration [GO:0043542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; leukocyte migration involved in inflammatory response [GO:0002523]; modulation of process of another organism [GO:0035821]; neutrophil aggregation [GO:0070488]; neutrophil chemotaxis [GO:0030593]; peptidyl-cysteine S-trans-nitrosylation [GO:0035606]; positive regulation of cell growth [GO:0030307]; positive regulation of inflammatory response [GO:0050729]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of cytoskeleton organization [GO:0051493]; regulation of integrin biosynthetic process [GO:0045113]; response to lipopolysaccharide [GO:0032496]; sequestering of zinc ion [GO:0032119]	SUBCELLULAR LOCATION: Secreted. Cytoplasm {ECO:0000269|PubMed:15598812, ECO:0000269|PubMed:8423249}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22489132, ECO:0000269|PubMed:9083090}. Cell membrane {ECO:0000269|PubMed:18786929}; Peripheral membrane protein {ECO:0000305|PubMed:18786929}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane (PubMed:18786929). Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway (PubMed:15598812). {ECO:0000269|PubMed:15598812, ECO:0000269|PubMed:18786929}.
P06703	reviewed	S10A6_HUMAN	Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6)	S100A6 CACY	Homo sapiens (Human)	90	FUNCTION: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. {ECO:0000269|PubMed:22399290}.	MISCELLANEOUS: This protein co-purified with the prolactin receptor.	axonogenesis [GO:0007409]; positive regulation of fibroblast proliferation [GO:0048146]; signal transduction [GO:0007165]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; monoatomic ion transmembrane transporter activity [GO:0015075]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]; tropomyosin binding [GO:0005523]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; monoatomic ion transmembrane transporter activity [GO:0015075]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]; tropomyosin binding [GO:0005523]; zinc ion binding [GO:0008270]; axonogenesis [GO:0007409]; positive regulation of fibroblast proliferation [GO:0048146]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
P06727	reviewed	APOA4_HUMAN	Apolipoprotein A-IV (Apo-AIV) (ApoA-IV) (Apolipoprotein A4)	APOA4	Homo sapiens (Human)	396	FUNCTION: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.		cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; chylomicron assembly [GO:0034378]; chylomicron remodeling [GO:0034371]; high-density lipoprotein particle remodeling [GO:0034375]; hydrogen peroxide catabolic process [GO:0042744]; innate immune response in mucosa [GO:0002227]; leukocyte cell-cell adhesion [GO:0007159]; lipid catabolic process [GO:0016042]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; negative regulation of plasma lipoprotein oxidation [GO:0034445]; peripheral nervous system axon regeneration [GO:0014012]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid efflux [GO:0033700]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of triglyceride catabolic process [GO:0010898]; protein-lipid complex assembly [GO:0065005]; regulation of cholesterol transport [GO:0032374]; regulation of intestinal cholesterol absorption [GO:0030300]; removal of superoxide radicals [GO:0019430]; response to lipid hydroperoxide [GO:0006982]; response to stilbenoid [GO:0035634]; response to triglyceride [GO:0034014]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; very-low-density lipoprotein particle remodeling [GO:0034372]	blood microparticle [GO:0072562]; chylomicron [GO:0042627]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; synapse [GO:0045202]; very-low-density lipoprotein particle [GO:0034361]	antioxidant activity [GO:0016209]; cholesterol transfer activity [GO:0120020]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; protein homodimerization activity [GO:0042803]	blood microparticle [GO:0072562]; chylomicron [GO:0042627]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; synapse [GO:0045202]; very-low-density lipoprotein particle [GO:0034361]; antioxidant activity [GO:0016209]; cholesterol transfer activity [GO:0120020]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; protein homodimerization activity [GO:0042803]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; chylomicron assembly [GO:0034378]; chylomicron remodeling [GO:0034371]; high-density lipoprotein particle remodeling [GO:0034375]; hydrogen peroxide catabolic process [GO:0042744]; innate immune response in mucosa [GO:0002227]; leukocyte cell-cell adhesion [GO:0007159]; lipid catabolic process [GO:0016042]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; negative regulation of plasma lipoprotein oxidation [GO:0034445]; peripheral nervous system axon regeneration [GO:0014012]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid efflux [GO:0033700]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of triglyceride catabolic process [GO:0010898]; protein-lipid complex assembly [GO:0065005]; regulation of cholesterol transport [GO:0032374]; regulation of intestinal cholesterol absorption [GO:0030300]; removal of superoxide radicals [GO:0019430]; response to lipid hydroperoxide [GO:0006982]; response to stilbenoid [GO:0035634]; response to triglyceride [GO:0034014]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; very-low-density lipoprotein particle remodeling [GO:0034372]	SUBCELLULAR LOCATION: Secreted.
P06729	reviewed	CD2_HUMAN	T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)	CD2 SRBC	Homo sapiens (Human)	351	FUNCTION: CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.		apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; heterotypic cell-cell adhesion [GO:0034113]; membrane raft polarization [GO:0001766]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of myeloid dendritic cell activation [GO:0030887]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of T cell differentiation [GO:0045580]; T cell activation [GO:0042110]	cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; protein self-association [GO:0043621]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; protein self-association [GO:0043621]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; heterotypic cell-cell adhesion [GO:0034113]; membrane raft polarization [GO:0001766]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of myeloid dendritic cell activation [GO:0030887]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of T cell differentiation [GO:0045580]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23006327, ECO:0000269|PubMed:2437578}; Single-pass type I membrane protein {ECO:0000305}.
P06730	reviewed	IF4E_HUMAN	Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)	EIF4E EIF4EL1 EIF4F	Homo sapiens (Human)	217	FUNCTION: Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606200, PubMed:24335285, PubMed:29987188, PubMed:22684010, PubMed:22578813). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (PubMed:29987188). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (PubMed:23471078). Promotes the nuclear export of MDM2 mRNA (PubMed:22684010). Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000250|UniProtKB:P63074, ECO:0000269|PubMed:11606200, ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:29987188}.	MISCELLANEOUS: The antiviral drug ribavirin relocalizes nuclear EIF4E to the cytoplasm and reduces the elevated EIF4E levels found in acute myeloid leukemia patients, suggesting its potential use as a therapeutic agent (PubMed:19433856). Ribavirin suppresses EIF4E-mediated oncogenic transformation by binding to EIF4E at the functional site used by the m7G mRNA cap and competing with the mRNA cap for binding to EIF4E which leads to relocalization of the majority of EIF4E to the cytoplasm and inhibition of nucleocytoplasmic mRNA transport (PubMed:15601771). {ECO:0000269|PubMed:15601771, ECO:0000269|PubMed:19433856}.	behavioral fear response [GO:0001662]; cellular response to dexamethasone stimulus [GO:0071549]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; neuron differentiation [GO:0030182]; nuclear export [GO:0051168]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of translation [GO:0006417]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; stem cell population maintenance [GO:0019827]; translational initiation [GO:0006413]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; mRNA cap binding complex [GO:0005845]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; RISC complex [GO:0016442]	DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; eukaryotic initiation factor 4G binding [GO:0031370]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation initiation factor activity [GO:0003743]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; mRNA cap binding complex [GO:0005845]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; RISC complex [GO:0016442]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; eukaryotic initiation factor 4G binding [GO:0031370]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation initiation factor activity [GO:0003743]; behavioral fear response [GO:0001662]; cellular response to dexamethasone stimulus [GO:0071549]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; neuron differentiation [GO:0030182]; nuclear export [GO:0051168]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of translation [GO:0006417]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; stem cell population maintenance [GO:0019827]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:25923732}. Cytoplasm {ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:12554669, ECO:0000269|PubMed:1384058, ECO:0000269|PubMed:15657436, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:36843541}. Cytoplasm, Stress granule {ECO:0000269|PubMed:21883093}. Nucleus {ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:11423616, ECO:0000269|PubMed:1384058, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:36843541}. Nucleus speckle {ECO:0000269|PubMed:10648556}. Nucleus, nuclear body {ECO:0000269|PubMed:12554669, ECO:0000269|PubMed:15657436}. Note=Interaction with EIF4ENIF1/4E-T is required for localization to processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:25923732). Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:10856257). Sequestered in the nucleus by EIF4EBP1 and EIF4EBP2 (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:25923732}.
P06731	reviewed	CEAM5_HUMAN	Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e)	CEACAM5 CEA	Homo sapiens (Human)	702	FUNCTION: Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:2803308}.; FUNCTION: (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. {ECO:0000269|PubMed:18086185}.		apoptotic process [GO:0006915]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; homotypic cell-cell adhesion [GO:0034109]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myotube differentiation [GO:0010832]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	GPI anchor binding [GO:0034235]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; GPI anchor binding [GO:0034235]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; apoptotic process [GO:0006915]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; homotypic cell-cell adhesion [GO:0034109]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myotube differentiation [GO:0010832]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:2317824}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:2317824}. Apical cell membrane {ECO:0000269|PubMed:10436421}. Cell surface {ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:2803308}. Note=Localized to the apical glycocalyx surface. {ECO:0000269|PubMed:10436421}.
P06732	reviewed	KCRM_HUMAN	Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK)	CKM CKMM	Homo sapiens (Human)	381	FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}.		phosphocreatine biosynthetic process [GO:0046314]; phosphorylation [GO:0016310]	cytosol [GO:0005829]; extracellular space [GO:0005615]	ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]	cytosol [GO:0005829]; extracellular space [GO:0005615]; ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; phosphocreatine biosynthetic process [GO:0046314]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm.
P06733	reviewed	ENOA_HUMAN	Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein)	ENO1 ENO1L1 MBPB1 MPB1	Homo sapiens (Human)	434	FUNCTION: Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:29775581, PubMed:1369209). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:2005901, PubMed:10802057, PubMed:12666133, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}.	MISCELLANEOUS: Used as a diagnostic marker for many tumors and, in the heterodimeric form, alpha/gamma, as a marker for hypoxic brain injury after cardiac arrest. Also marker for endometriosis. Antibodies against alpha-enolase are present in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive blinding disease which occurs in the presence of systemic tumor growth, primarily small-cell carcinoma of the lung and other malignancies. Is identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive processes overcome the potential capacity of thyroid replacement leading to hypothyroidism.; MISCELLANEOUS: [Isoform MBP-1]: It is uncertain whether the alternative initiation site is at Met-94 or at Met-97. {ECO:0000305}.	canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of muscle contraction [GO:0045933]; positive regulation of plasminogen activation [GO:0010756]; response to virus [GO:0009615]	cell cortex [GO:0005938]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; M band [GO:0031430]; membrane [GO:0016020]; nuclear outer membrane [GO:0005640]; nucleus [GO:0005634]; phosphopyruvate hydratase complex [GO:0000015]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; GTPase binding [GO:0051020]; magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]	cell cortex [GO:0005938]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; M band [GO:0031430]; membrane [GO:0016020]; nuclear outer membrane [GO:0005640]; nucleus [GO:0005634]; phosphopyruvate hydratase complex [GO:0000015]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; GTPase binding [GO:0051020]; magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of muscle contraction [GO:0045933]; positive regulation of plasminogen activation [GO:0010756]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10802057}. Cell membrane {ECO:0000269|PubMed:10802057}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:10802057}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.; SUBCELLULAR LOCATION: [Isoform MBP-1]: Nucleus.
P06734	reviewed	FCER2_HUMAN	Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form]	FCER2 CD23A CLEC4J FCE2 IGEBF	Homo sapiens (Human)	321	FUNCTION: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225). On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway (PubMed:7544003). {ECO:0000269|PubMed:2167225, ECO:0000269|PubMed:7544003}.	MISCELLANEOUS: There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.	B cell antigen processing and presentation [GO:0002450]; Fc receptor-mediated immune complex endocytosis [GO:0160006]; immune response [GO:0006955]; macrophage activation [GO:0042116]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of another organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; IgE binding [GO:0019863]; integrin binding [GO:0005178]; low-affinity IgE receptor activity [GO:0019769]; metal ion binding [GO:0046872]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; IgE binding [GO:0019863]; integrin binding [GO:0005178]; low-affinity IgE receptor activity [GO:0019769]; metal ion binding [GO:0046872]; B cell antigen processing and presentation [GO:0002450]; Fc receptor-mediated immune complex endocytosis [GO:0160006]; immune response [GO:0006955]; macrophage activation [GO:0042116]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of another organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23.
P06737	reviewed	PYGL_HUMAN	Glycogen phosphorylase, liver form (EC 2.4.1.1)	PYGL	Homo sapiens (Human)	847	FUNCTION: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. {ECO:0000269|PubMed:22225877}.		5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; glucose homeostasis [GO:0042593]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; necroptotic process [GO:0070266]; response to bacterium [GO:0009617]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]	AMP binding [GO:0016208]; ATP binding [GO:0005524]; bile acid binding [GO:0032052]; glucose binding [GO:0005536]; glycogen phosphorylase activity [GO:0008184]; identical protein binding [GO:0042802]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; purine nucleobase binding [GO:0002060]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499]; vitamin binding [GO:0019842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; bile acid binding [GO:0032052]; glucose binding [GO:0005536]; glycogen phosphorylase activity [GO:0008184]; identical protein binding [GO:0042802]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; purine nucleobase binding [GO:0002060]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499]; vitamin binding [GO:0019842]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; glucose homeostasis [GO:0042593]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; necroptotic process [GO:0070266]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:22225877}.
P06744	reviewed	G6PI_HUMAN	Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36)	GPI	Homo sapiens (Human)	558	FUNCTION: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:3352745, PubMed:11004567). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:3352745, PubMed:11004567). {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381, ECO:0000269|PubMed:28803808, ECO:0000269|PubMed:3352745}.		carbohydrate metabolic process [GO:0005975]; erythrocyte homeostasis [GO:0034101]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose homeostasis [GO:0042593]; glycolytic process [GO:0006096]; hemostasis [GO:0007599]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; learning or memory [GO:0007611]; mesoderm formation [GO:0001707]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of immunoglobulin production [GO:0002639]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to immobilization stress [GO:0035902]; response to muscle stretch [GO:0035994]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]	ciliary membrane [GO:0060170]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]	carbohydrate derivative binding [GO:0097367]; cytokine activity [GO:0005125]; glucose-6-phosphate isomerase activity [GO:0004347]; growth factor activity [GO:0008083]; monosaccharide binding [GO:0048029]; ubiquitin protein ligase binding [GO:0031625]	ciliary membrane [GO:0060170]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]; carbohydrate derivative binding [GO:0097367]; cytokine activity [GO:0005125]; glucose-6-phosphate isomerase activity [GO:0004347]; growth factor activity [GO:0008083]; monosaccharide binding [GO:0048029]; ubiquitin protein ligase binding [GO:0031625]; carbohydrate metabolic process [GO:0005975]; erythrocyte homeostasis [GO:0034101]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose homeostasis [GO:0042593]; glycolytic process [GO:0006096]; hemostasis [GO:0007599]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; learning or memory [GO:0007611]; mesoderm formation [GO:0001707]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of immunoglobulin production [GO:0002639]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to immobilization stress [GO:0035902]; response to muscle stretch [GO:0035994]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11437381}. Secreted {ECO:0000269|PubMed:11437381}.
P06746	reviewed	DPOLB_HUMAN	DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18)	POLB	Homo sapiens (Human)	335	FUNCTION: Repair polymerase that plays a key role in base-excision repair (PubMed:9207062, PubMed:9572863, PubMed:10556592). During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap (PubMed:9572863, PubMed:9556598, PubMed:9614142, PubMed:10556592, PubMed:17526740). Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase (PubMed:9614142). {ECO:0000269|PubMed:10556592, ECO:0000269|PubMed:11805079, ECO:0000269|PubMed:17526740, ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9556598, ECO:0000269|PubMed:9572863, ECO:0000269|PubMed:9614142}.		base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via nonhomologous end joining [GO:0006303]; homeostasis of number of cells [GO:0048872]; immunoglobulin heavy chain V-D-J recombination [GO:0071707]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lymph node development [GO:0048535]; neuron apoptotic process [GO:0051402]; pyrimidine dimer repair [GO:0006290]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to hyperoxia [GO:0055093]; salivary gland morphogenesis [GO:0007435]; somatic hypermutation of immunoglobulin genes [GO:0016446]; spleen development [GO:0048536]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle microtubule [GO:0005876]	5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; DNA-directed DNA polymerase activity [GO:0003887]; enzyme binding [GO:0019899]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle microtubule [GO:0005876]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; DNA-directed DNA polymerase activity [GO:0003887]; enzyme binding [GO:0019899]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via nonhomologous end joining [GO:0006303]; homeostasis of number of cells [GO:0048872]; immunoglobulin heavy chain V-D-J recombination [GO:0071707]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lymph node development [GO:0048535]; neuron apoptotic process [GO:0051402]; pyrimidine dimer repair [GO:0006290]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to hyperoxia [GO:0055093]; salivary gland morphogenesis [GO:0007435]; somatic hypermutation of immunoglobulin genes [GO:0016446]; spleen development [GO:0048536]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
P06748	reviewed	NPM_HUMAN	Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)	NPM1 NPM	Homo sapiens (Human)	294	FUNCTION: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}.		cell volume homeostasis [GO:0006884]; cellular response to UV [GO:0034644]; cellular senescence [GO:0090398]; centrosome cycle [GO:0007098]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; intracellular protein transport [GO:0006886]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of centrosome duplication [GO:0010826]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; nucleocytoplasmic transport [GO:0006913]; nucleosome assembly [GO:0006334]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; regulation of cell growth [GO:0001558]; regulation of centriole replication [GO:0046599]; regulation of centrosome duplication [GO:0010824]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of eIF2 alpha phosphorylation by dsRNA [GO:0060735]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of endoribonuclease activity [GO:0060699]; regulation of mRNA stability involved in cellular response to UV [GO:1902629]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]; ribosome assembly [GO:0042255]; rRNA export from nucleus [GO:0006407]; signal transduction [GO:0007165]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; granular component [GO:0001652]; large ribosomal subunit [GO:0015934]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; small ribosomal subunit [GO:0015935]; spindle pole centrosome [GO:0031616]	chromatin binding [GO:0003682]; core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; molecular condensate scaffold activity [GO:0140693]; NF-kappaB binding [GO:0051059]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; unfolded protein binding [GO:0051082]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; granular component [GO:0001652]; large ribosomal subunit [GO:0015934]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; small ribosomal subunit [GO:0015935]; spindle pole centrosome [GO:0031616]; chromatin binding [GO:0003682]; core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; molecular condensate scaffold activity [GO:0140693]; NF-kappaB binding [GO:0051059]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; unfolded protein binding [GO:0051082]; cell volume homeostasis [GO:0006884]; cellular response to UV [GO:0034644]; cellular senescence [GO:0090398]; centrosome cycle [GO:0007098]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; intracellular protein transport [GO:0006886]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of centrosome duplication [GO:0010826]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; nucleocytoplasmic transport [GO:0006913]; nucleosome assembly [GO:0006334]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; regulation of cell growth [GO:0001558]; regulation of centriole replication [GO:0046599]; regulation of centrosome duplication [GO:0010824]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of eIF2 alpha phosphorylation by dsRNA [GO:0060735]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of endoribonuclease activity [GO:0060699]; regulation of mRNA stability involved in cellular response to UV [GO:1902629]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]; ribosome assembly [GO:0042255]; rRNA export from nucleus [GO:0006407]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25818168, ECO:0000269|PubMed:25956029}. Nucleus, nucleoplasm {ECO:0000269|PubMed:25818168}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co- localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis.
P06753	reviewed	TPM3_HUMAN	Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)	TPM3	Homo sapiens (Human)	285	FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}.	MISCELLANEOUS: [Isoform 2]: Peptides 2-27, 41-55, 132-153, 163-169, 216-225 and 237-248 have been identified and sequenced by MS. PubMed:16201836 (ABC40673) sequence corresponds to a TPM3 retrocopy (rcTPM3) on chromosome 16 that is generated by retroposition of reversed transcribed mRNA back to the genome. rcTPM3 functionality is uncertain. It has been detected by MS in primary breast cancer tissues. {ECO:0000269|Ref.10, ECO:0000269|Ref.9, ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Peptides 2-27, 41-55, 132-153 and 163-169 have been identified and sequenced by MS. {ECO:0000269|Ref.10, ECO:0000269|Ref.9, ECO:0000305}.	actin filament organization [GO:0007015]; muscle contraction [GO:0006936]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle thin filament tropomyosin [GO:0005862]; stress fiber [GO:0001725]	actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle thin filament tropomyosin [GO:0005862]; stress fiber [GO:0001725]; actin filament binding [GO:0051015]; actin filament organization [GO:0007015]; muscle contraction [GO:0006936]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
P06756	reviewed	ITAV_HUMAN	Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]	ITGAV MSK8 VNRA VTNR	Homo sapiens (Human)	1048	FUNCTION: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 acts as a receptor for CD40LG (PubMed:31331973). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28117447, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. {ECO:0000269|PubMed:20615244}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:7519807, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. {ECO:0000269|PubMed:24367260}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.		angiogenesis [GO:0001525]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; apoptotic cell clearance [GO:0043277]; calcium ion transmembrane transport [GO:0070588]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; endodermal cell differentiation [GO:0035987]; entry into host cell by a symbiont-containing vacuole [GO:0085017]; ERK1 and ERK2 cascade [GO:0070371]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; negative regulation of entry of bacterium into host cell [GO:2000536]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; regulation of phagocytosis [GO:0050764]; regulation of transforming growth factor beta activation [GO:1901388]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta production [GO:0071604]; vasculogenesis [GO:0001570]; viral entry into host cell [GO:0046718]	alphav-beta3 integrin-HMGB1 complex [GO:0035868]; alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; alphav-beta3 integrin-PKCalpha complex [GO:0035866]; cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; integrin alphav-beta3 complex [GO:0034683]; integrin alphav-beta5 complex [GO:0034684]; integrin alphav-beta6 complex [GO:0034685]; integrin alphav-beta8 complex [GO:0034686]; integrin complex [GO:0008305]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; specific granule membrane [GO:0035579]	coreceptor activity [GO:0015026]; extracellular matrix binding [GO:0050840]; extracellular matrix protein binding [GO:1990430]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; opsonin binding [GO:0001846]; protease binding [GO:0002020]; protein kinase C binding [GO:0005080]; transforming growth factor beta binding [GO:0050431]; virus receptor activity [GO:0001618]; voltage-gated calcium channel activity [GO:0005245]	alphav-beta3 integrin-HMGB1 complex [GO:0035868]; alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; alphav-beta3 integrin-PKCalpha complex [GO:0035866]; cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; integrin alphav-beta3 complex [GO:0034683]; integrin alphav-beta5 complex [GO:0034684]; integrin alphav-beta6 complex [GO:0034685]; integrin alphav-beta8 complex [GO:0034686]; integrin complex [GO:0008305]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; specific granule membrane [GO:0035579]; coreceptor activity [GO:0015026]; extracellular matrix binding [GO:0050840]; extracellular matrix protein binding [GO:1990430]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; opsonin binding [GO:0001846]; protease binding [GO:0002020]; protein kinase C binding [GO:0005080]; transforming growth factor beta binding [GO:0050431]; virus receptor activity [GO:0001618]; voltage-gated calcium channel activity [GO:0005245]; angiogenesis [GO:0001525]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; apoptotic cell clearance [GO:0043277]; calcium ion transmembrane transport [GO:0070588]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; endodermal cell differentiation [GO:0035987]; entry into host cell by a symbiont-containing vacuole [GO:0085017]; ERK1 and ERK2 cascade [GO:0070371]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; negative regulation of entry of bacterium into host cell [GO:2000536]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; regulation of phagocytosis [GO:0050764]; regulation of transforming growth factor beta activation [GO:1901388]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta production [GO:0071604]; vasculogenesis [GO:0001570]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}.
P06850	reviewed	CRF_HUMAN	Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone)	CRH	Homo sapiens (Human)	196	FUNCTION: Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). {ECO:0000250|UniProtKB:P06296, ECO:0000250|UniProtKB:Q8CIT0}.		adrenal gland development [GO:0030325]; chemical synaptic transmission [GO:0007268]; female pregnancy [GO:0007565]; glucocorticoid biosynthetic process [GO:0006704]; inflammatory response [GO:0006954]; learning or memory [GO:0007611]; locomotory exploration behavior [GO:0035641]; lung development [GO:0030324]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of glucagon secretion [GO:0070093]; parturition [GO:0007567]; positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841]; positive regulation of corticotropin secretion [GO:0051461]; positive regulation of cortisol secretion [GO:0051464]; regulation of NMDA receptor activity [GO:2000310]; signal transduction [GO:0007165]; synaptic transmission, dopaminergic [GO:0001963]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; synapse [GO:0045202]	corticotropin-releasing hormone activity [GO:0017045]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; synapse [GO:0045202]; corticotropin-releasing hormone activity [GO:0017045]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102]; adrenal gland development [GO:0030325]; chemical synaptic transmission [GO:0007268]; female pregnancy [GO:0007565]; glucocorticoid biosynthetic process [GO:0006704]; inflammatory response [GO:0006954]; learning or memory [GO:0007611]; locomotory exploration behavior [GO:0035641]; lung development [GO:0030324]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of glucagon secretion [GO:0070093]; parturition [GO:0007567]; positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841]; positive regulation of corticotropin secretion [GO:0051461]; positive regulation of cortisol secretion [GO:0051464]; regulation of NMDA receptor activity [GO:2000310]; signal transduction [GO:0007165]; synaptic transmission, dopaminergic [GO:0001963]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P06296}.
P06858	reviewed	LIPL_HUMAN	Lipoprotein lipase (LPL) (EC 3.1.1.34) (Phospholipase A1) (EC 3.1.1.32)	LPL LIPD	Homo sapiens (Human)	475	FUNCTION: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:8675619, PubMed:11342582, PubMed:27578112). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (PubMed:7592706, PubMed:12032167). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (PubMed:24726386). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (PubMed:11342582, PubMed:27811232). {ECO:0000269|PubMed:11342582, ECO:0000269|PubMed:12032167, ECO:0000269|PubMed:24726386, ECO:0000269|PubMed:27578112, ECO:0000269|PubMed:27811232, ECO:0000269|PubMed:7592706, ECO:0000269|PubMed:8675619}.		cellular response to fatty acid [GO:0071398]; cellular response to nutrient [GO:0031670]; cholesterol homeostasis [GO:0042632]; chylomicron remodeling [GO:0034371]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; low-density lipoprotein particle mediated signaling [GO:0055096]; phospholipid metabolic process [GO:0006644]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine production [GO:0032722]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of sequestering of triglyceride [GO:0010890]; positive regulation of tumor necrosis factor production [GO:0032760]; response to bacterium [GO:0009617]; response to glucose [GO:0009749]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle remodeling [GO:0034372]	catalytic complex [GO:1902494]; cell surface [GO:0009986]; chylomicron [GO:0042627]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361]	1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; lipoprotein particle binding [GO:0071813]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; triglyceride lipase activity [GO:0004806]	catalytic complex [GO:1902494]; cell surface [GO:0009986]; chylomicron [GO:0042627]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361]; 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; lipoprotein particle binding [GO:0071813]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; triglyceride lipase activity [GO:0004806]; cellular response to fatty acid [GO:0071398]; cellular response to nutrient [GO:0031670]; cholesterol homeostasis [GO:0042632]; chylomicron remodeling [GO:0034371]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; low-density lipoprotein particle mediated signaling [GO:0055096]; phospholipid metabolic process [GO:0006644]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine production [GO:0032722]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of sequestering of triglyceride [GO:0010890]; positive regulation of tumor necrosis factor production [GO:0032760]; response to bacterium [GO:0009617]; response to glucose [GO:0009749]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle remodeling [GO:0034372]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P11151}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11151}; Extracellular side {ECO:0000250|UniProtKB:P11151}. Secreted {ECO:0000269|PubMed:11342582, ECO:0000269|PubMed:11893776, ECO:0000269|PubMed:12641539, ECO:0000269|PubMed:1371284, ECO:0000269|PubMed:2340307, ECO:0000269|PubMed:24291057, ECO:0000269|PubMed:27578112, ECO:0000269|PubMed:30559189}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:27811232}. Note=Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently, it becomes attached to heparan proteoglycan on endothelial cells (PubMed:27811232). Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity). {ECO:0000250|UniProtKB:P11151, ECO:0000269|PubMed:27811232}.
P06865	reviewed	HEXA_HUMAN	Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha)	HEXA	Homo sapiens (Human)	529	FUNCTION: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:9694901, PubMed:8672428, PubMed:8123671). The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2 (PubMed:11707436). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:9694901, PubMed:8672428, PubMed:8123671). {ECO:0000269|PubMed:11707436, ECO:0000269|PubMed:8123671, ECO:0000269|PubMed:8672428, ECO:0000269|PubMed:9694901}.		adult walking behavior [GO:0007628]; cell morphogenesis involved in neuron differentiation [GO:0048667]; dermatan sulfate catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; lipid storage [GO:0019915]; lysosome organization [GO:0007040]; maintenance of location in cell [GO:0051651]; myelination [GO:0042552]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; sensory perception of sound [GO:0007605]; sexual reproduction [GO:0019953]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395]	azurophil granule [GO:0042582]; beta-N-acetylhexosaminidase complex [GO:1905379]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]	acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylhexosaminidase activity [GO:0004563]; N-acetyl-beta-D-galactosaminidase activity [GO:0102148]; protein heterodimerization activity [GO:0046982]	azurophil granule [GO:0042582]; beta-N-acetylhexosaminidase complex [GO:1905379]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylhexosaminidase activity [GO:0004563]; N-acetyl-beta-D-galactosaminidase activity [GO:0102148]; protein heterodimerization activity [GO:0046982]; adult walking behavior [GO:0007628]; cell morphogenesis involved in neuron differentiation [GO:0048667]; dermatan sulfate catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; lipid storage [GO:0019915]; lysosome organization [GO:0007040]; maintenance of location in cell [GO:0051651]; myelination [GO:0042552]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; sensory perception of sound [GO:0007605]; sexual reproduction [GO:0019953]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395]	SUBCELLULAR LOCATION: Lysosome.
P06870	reviewed	KLK1_HUMAN	Kallikrein-1 (EC 3.4.21.35) (Kidney/pancreas/salivary gland kallikrein) (Tissue kallikrein)	KLK1	Homo sapiens (Human)	262	FUNCTION: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.; FUNCTION: (Microbial infection) Cleaves Neisseria meningitidis NHBA in saliva; Neisseria is an obligate commensal of the nasopharyngeal mucosa. {ECO:0000269|PubMed:31369555}.		regulation of systemic arterial blood pressure [GO:0003073]; zymogen activation [GO:0031638]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]; secretory granule [GO:0030141]	serine-type endopeptidase activity [GO:0004252]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]; regulation of systemic arterial blood pressure [GO:0003073]; zymogen activation [GO:0031638]	
P06881	reviewed	CALCA_HUMAN	Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)	CALCA CALC1	Homo sapiens (Human)	128	FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. {ECO:0000269|PubMed:1318039}.		activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor signaling pathway [GO:0097647]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; cell-cell signaling [GO:0007267]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor internalization [GO:0002031]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of blood pressure [GO:0045776]; negative regulation of bone resorption [GO:0045779]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of osteoclast differentiation [GO:0045671]; nervous system process involved in regulation of systemic arterial blood pressure [GO:0001976]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage differentiation [GO:0045651]; protein phosphorylation [GO:0006468]; receptor internalization [GO:0031623]; regulation of blood pressure [GO:0008217]; regulation of cytosolic calcium ion concentration [GO:0051480]; vasculature development [GO:0001944]; vasodilation [GO:0042311]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	hormone activity [GO:0005179]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor signaling pathway [GO:0097647]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; cell-cell signaling [GO:0007267]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor internalization [GO:0002031]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of blood pressure [GO:0045776]; negative regulation of bone resorption [GO:0045779]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of osteoclast differentiation [GO:0045671]; nervous system process involved in regulation of systemic arterial blood pressure [GO:0001976]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage differentiation [GO:0045651]; protein phosphorylation [GO:0006468]; receptor internalization [GO:0031623]; regulation of blood pressure [GO:0008217]; regulation of cytosolic calcium ion concentration [GO:0051480]; vasculature development [GO:0001944]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Secreted.
P06899	reviewed	H2B1J_HUMAN	Histone H2B type 1-J (Histone H2B.1) (Histone H2B.r) (H2B/r)	H2BC11 H2BFR HIST1H2BJ	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chromatin organization [GO:0006325]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; killing of cells of another organism [GO:0031640]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nucleosome assembly [GO:0006334]; protein localization to CENP-A containing chromatin [GO:0061644]	CENP-A containing nucleosome [GO:0043505]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; lipopolysaccharide binding [GO:0001530]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	CENP-A containing nucleosome [GO:0043505]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; lipopolysaccharide binding [GO:0001530]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chromatin organization [GO:0006325]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; killing of cells of another organism [GO:0031640]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nucleosome assembly [GO:0006334]; protein localization to CENP-A containing chromatin [GO:0061644]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P07093	reviewed	GDN_HUMAN	Glia-derived nexin (GDN) (Peptidase inhibitor 7) (PI-7) (Protease nexin 1) (PN-1) (Protease nexin I) (Serpin E2)	SERPINE2 PI7 PN1	Homo sapiens (Human)	398	FUNCTION: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.		cell differentiation [GO:0030154]; cerebellar granular layer morphogenesis [GO:0021683]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; innervation [GO:0060384]; long-term synaptic potentiation [GO:0060291]; mating plug formation [GO:0042628]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of proteolysis [GO:0045861]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of sodium ion transport [GO:0010766]; platelet activation [GO:0030168]; positive regulation of astrocyte differentiation [GO:0048711]; protein catabolic process [GO:0030163]; regulation of cell migration [GO:0030334]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of timing of cell differentiation [GO:0048505]; secretion by cell [GO:0032940]; secretory granule organization [GO:0033363]; seminal vesicle epithelium development [GO:0061108]	collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; neuromuscular junction [GO:0031594]; platelet alpha granule [GO:0031091]	glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]	collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; neuromuscular junction [GO:0031594]; platelet alpha granule [GO:0031091]; glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]; cell differentiation [GO:0030154]; cerebellar granular layer morphogenesis [GO:0021683]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; innervation [GO:0060384]; long-term synaptic potentiation [GO:0060291]; mating plug formation [GO:0042628]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of proteolysis [GO:0045861]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of sodium ion transport [GO:0010766]; platelet activation [GO:0030168]; positive regulation of astrocyte differentiation [GO:0048711]; protein catabolic process [GO:0030163]; regulation of cell migration [GO:0030334]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of timing of cell differentiation [GO:0048505]; secretion by cell [GO:0032940]; secretory granule organization [GO:0033363]; seminal vesicle epithelium development [GO:0061108]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P07098	reviewed	LIPF_HUMAN	Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3)	LIPF	Homo sapiens (Human)	398	FUNCTION: Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:2243091, PubMed:10358049). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (PubMed:2243091). {ECO:0000269|PubMed:10358049, ECO:0000269|PubMed:2243091}.		lipid catabolic process [GO:0016042]; malate metabolic process [GO:0006108]; triglyceride metabolic process [GO:0006641]	extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]	lipid binding [GO:0008289]; malate dehydrogenase activity [GO:0016615]; triglyceride lipase activity [GO:0004806]	extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; lipid binding [GO:0008289]; malate dehydrogenase activity [GO:0016615]; triglyceride lipase activity [GO:0004806]; lipid catabolic process [GO:0016042]; malate metabolic process [GO:0006108]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P80035}.
P07099	reviewed	HYEP_HUMAN	Epoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase) (mEH)	EPHX1 EPHX EPOX	Homo sapiens (Human)	455	FUNCTION: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911). {ECO:0000250|UniProtKB:P07687, ECO:0000269|PubMed:22798687, ECO:0000269|PubMed:24958911}.		arachidonic acid metabolic process [GO:0019369]; aromatic compound catabolic process [GO:0019439]; epoxide metabolic process [GO:0097176]; response to organic cyclic compound [GO:0014070]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]	cis-stilbene-oxide hydrolase activity [GO:0033961]; epoxide hydrolase activity [GO:0004301]	endoplasmic reticulum membrane [GO:0005789]; cis-stilbene-oxide hydrolase activity [GO:0033961]; epoxide hydrolase activity [GO:0004301]; arachidonic acid metabolic process [GO:0019369]; aromatic compound catabolic process [GO:0019439]; epoxide metabolic process [GO:0097176]; response to organic cyclic compound [GO:0014070]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:24958911}; Single-pass type III membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P07687}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:P07687}.
P07101	reviewed	TY3H_HUMAN	Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH)	TH TYH	Homo sapiens (Human)	528	FUNCTION: Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:17391063, PubMed:1680128, PubMed:15287903, PubMed:8528210, Ref.18, PubMed:34922205, PubMed:24753243). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). {ECO:0000250|UniProtKB:P04177, ECO:0000250|UniProtKB:P24529, ECO:0000269|PubMed:15287903, ECO:0000269|PubMed:1680128, ECO:0000269|PubMed:17391063, ECO:0000269|PubMed:24753243, ECO:0000269|PubMed:34922205, ECO:0000269|PubMed:8528210, ECO:0000269|Ref.18}.; FUNCTION: [Isoform 5]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}.; FUNCTION: [Isoform 6]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}.		aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; cellular response to alkaloid [GO:0071312]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cellular response to manganese ion [GO:0071287]; cellular response to nicotine [GO:0071316]; cellular response to xenobiotic stimulus [GO:0071466]; cerebral cortex development [GO:0021987]; circadian sleep/wake cycle [GO:0042745]; dopamine biosynthetic process [GO:0042416]; dopamine biosynthetic process from tyrosine [GO:0006585]; eating behavior [GO:0042755]; embryonic camera-type eye morphogenesis [GO:0048596]; epinephrine biosynthetic process [GO:0042418]; eye photoreceptor cell development [GO:0042462]; fatty acid metabolic process [GO:0006631]; glycoside metabolic process [GO:0016137]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; hyaloid vascular plexus regression [GO:1990384]; isoquinoline alkaloid metabolic process [GO:0033076]; learning [GO:0007612]; locomotory behavior [GO:0007626]; mating behavior [GO:0007617]; memory [GO:0007613]; neurotransmitter biosynthetic process [GO:0042136]; norepinephrine biosynthetic process [GO:0042421]; phthalate metabolic process [GO:0018963]; phytoalexin metabolic process [GO:0052314]; pigmentation [GO:0043473]; regulation of heart contraction [GO:0008016]; response to activity [GO:0014823]; response to amphetamine [GO:0001975]; response to corticosterone [GO:0051412]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to ether [GO:0045472]; response to herbicide [GO:0009635]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to isolation stress [GO:0035900]; response to light stimulus [GO:0009416]; response to lipopolysaccharide [GO:0032496]; response to nutrient levels [GO:0031667]; response to peptide hormone [GO:0043434]; response to pyrethroid [GO:0046684]; response to salt stress [GO:0009651]; response to zinc ion [GO:0010043]; social behavior [GO:0035176]; sphingolipid metabolic process [GO:0006665]; synaptic transmission, dopaminergic [GO:0001963]; terpene metabolic process [GO:0042214]; visual perception [GO:0007601]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; melanosome membrane [GO:0033162]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; smooth endoplasmic reticulum [GO:0005790]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195]	amino acid binding [GO:0016597]; dopamine binding [GO:0035240]; enzyme binding [GO:0019899]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; identical protein binding [GO:0042802]; oxygen binding [GO:0019825]; protein domain specific binding [GO:0019904]; tetrahydrobiopterin binding [GO:0034617]; tyrosine 3-monooxygenase activity [GO:0004511]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; melanosome membrane [GO:0033162]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; smooth endoplasmic reticulum [GO:0005790]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195]; amino acid binding [GO:0016597]; dopamine binding [GO:0035240]; enzyme binding [GO:0019899]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; identical protein binding [GO:0042802]; oxygen binding [GO:0019825]; protein domain specific binding [GO:0019904]; tetrahydrobiopterin binding [GO:0034617]; tyrosine 3-monooxygenase activity [GO:0004511]; aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; cellular response to alkaloid [GO:0071312]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cellular response to manganese ion [GO:0071287]; cellular response to nicotine [GO:0071316]; cellular response to xenobiotic stimulus [GO:0071466]; cerebral cortex development [GO:0021987]; circadian sleep/wake cycle [GO:0042745]; dopamine biosynthetic process [GO:0042416]; dopamine biosynthetic process from tyrosine [GO:0006585]; eating behavior [GO:0042755]; embryonic camera-type eye morphogenesis [GO:0048596]; epinephrine biosynthetic process [GO:0042418]; eye photoreceptor cell development [GO:0042462]; fatty acid metabolic process [GO:0006631]; glycoside metabolic process [GO:0016137]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; hyaloid vascular plexus regression [GO:1990384]; isoquinoline alkaloid metabolic process [GO:0033076]; learning [GO:0007612]; locomotory behavior [GO:0007626]; mating behavior [GO:0007617]; memory [GO:0007613]; neurotransmitter biosynthetic process [GO:0042136]; norepinephrine biosynthetic process [GO:0042421]; phthalate metabolic process [GO:0018963]; phytoalexin metabolic process [GO:0052314]; pigmentation [GO:0043473]; regulation of heart contraction [GO:0008016]; response to activity [GO:0014823]; response to amphetamine [GO:0001975]; response to corticosterone [GO:0051412]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to ether [GO:0045472]; response to herbicide [GO:0009635]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to isolation stress [GO:0035900]; response to light stimulus [GO:0009416]; response to lipopolysaccharide [GO:0032496]; response to nutrient levels [GO:0031667]; response to peptide hormone [GO:0043434]; response to pyrethroid [GO:0046684]; response to salt stress [GO:0009651]; response to zinc ion [GO:0010043]; social behavior [GO:0035176]; sphingolipid metabolic process [GO:0006665]; synaptic transmission, dopaminergic [GO:0001963]; terpene metabolic process [GO:0042214]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P24529}. Nucleus {ECO:0000250|UniProtKB:P04177}. Cell projection, axon {ECO:0000250|UniProtKB:P24529}. Cytoplasm {ECO:0000250|UniProtKB:P04177}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:P04177}. Note=When phosphorylated at Ser-19 shows a nuclear distribution and when phosphorylated at Ser-31 as well at Ser-40 shows a cytosolic distribution (By similarity). Expressed in dopaminergic axons and axon terminals. {ECO:0000250|UniProtKB:P04177}.
P07108	reviewed	ACBP_HUMAN	Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP)	DBI	Homo sapiens (Human)	87	FUNCTION: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.	MISCELLANEOUS: [Isoform 6]: Predominantly expressed in adipose tissue and hippocampus. {ECO:0000305}.	fatty acid metabolic process [GO:0006631]; negative regulation of protein lipidation [GO:1903060]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of phospholipid transport [GO:2001140]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear endoplasmic reticulum [GO:0097038]; protein-lipid complex [GO:0032994]	benzodiazepine receptor binding [GO:0030156]; fatty-acyl-CoA binding [GO:0000062]; identical protein binding [GO:0042802]; long-chain fatty acyl-CoA binding [GO:0036042]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear endoplasmic reticulum [GO:0097038]; protein-lipid complex [GO:0032994]; benzodiazepine receptor binding [GO:0030156]; fatty-acyl-CoA binding [GO:0000062]; identical protein binding [GO:0042802]; long-chain fatty acyl-CoA binding [GO:0036042]; fatty acid metabolic process [GO:0006631]; negative regulation of protein lipidation [GO:1903060]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of phospholipid transport [GO:2001140]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:17953517, ECO:0000269|PubMed:21698759}. Golgi apparatus {ECO:0000269|PubMed:17953517, ECO:0000269|PubMed:21698759}. Note=Golgi localization is dependent on ligand binding (PubMed:17953517). {ECO:0000269|PubMed:17953517}.
P07148	reviewed	FABPL_HUMAN	Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver-type fatty acid-binding protein) (L-FABP)	FABP1 FABPL	Homo sapiens (Human)	127	FUNCTION: Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). {ECO:0000250|UniProtKB:P82289, ECO:0000269|PubMed:25732850}.		cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; fatty acid transport [GO:0015908]; intestinal absorption [GO:0050892]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; positive regulation of fatty acid beta-oxidation [GO:0032000]	apical cortex [GO:0045179]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; protein-containing complex [GO:0032991]	antioxidant activity [GO:0016209]; bile acid binding [GO:0032052]; chromatin binding [GO:0003682]; fatty acid binding [GO:0005504]; heterocyclic compound binding [GO:1901363]; long-chain fatty acid transporter activity [GO:0005324]; oleic acid binding [GO:0070538]; phospholipid binding [GO:0005543]	apical cortex [GO:0045179]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; protein-containing complex [GO:0032991]; antioxidant activity [GO:0016209]; bile acid binding [GO:0032052]; chromatin binding [GO:0003682]; fatty acid binding [GO:0005504]; heterocyclic compound binding [GO:1901363]; long-chain fatty acid transporter activity [GO:0005324]; oleic acid binding [GO:0070538]; phospholipid binding [GO:0005543]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; fatty acid transport [GO:0015908]; intestinal absorption [GO:0050892]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; positive regulation of fatty acid beta-oxidation [GO:0032000]	SUBCELLULAR LOCATION: Cytoplasm.
P07195	reviewed	LDHB_HUMAN	L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46)	LDHB	Homo sapiens (Human)	334	FUNCTION: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}.		lactate metabolic process [GO:0006089]; NAD metabolic process [GO:0019674]; pyruvate metabolic process [GO:0006090]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; oxidoreductase complex [GO:1990204]	identical protein binding [GO:0042802]; kinase binding [GO:0019900]; L-lactate dehydrogenase activity [GO:0004459]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; oxidoreductase complex [GO:1990204]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; L-lactate dehydrogenase activity [GO:0004459]; NAD binding [GO:0051287]; lactate metabolic process [GO:0006089]; NAD metabolic process [GO:0019674]; pyruvate metabolic process [GO:0006090]	SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion inner membrane {ECO:0000269|PubMed:27618187}; Peripheral membrane protein {ECO:0000305}.
P07196	reviewed	NFL_HUMAN	Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)	NEFL NF68 NFL	Homo sapiens (Human)	543	FUNCTION: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08551}.	MISCELLANEOUS: NF-L is the most abundant of the three neurofilament proteins and, like the other nonepithelial intermediate filament proteins, it can form homomeric 10-nm filaments.	anterograde axonal transport [GO:0008089]; axonal transport of mitochondrion [GO:0019896]; axonogenesis [GO:0007409]; cerebral cortex development [GO:0021987]; hippocampus development [GO:0021766]; intermediate filament organization [GO:0045109]; intermediate filament polymerization or depolymerization [GO:0045105]; locomotion [GO:0040011]; microtubule cytoskeleton organization [GO:0000226]; motor neuron apoptotic process [GO:0097049]; negative regulation of motor neuron apoptotic process [GO:2000672]; neurofilament bundle assembly [GO:0033693]; neurofilament cytoskeleton organization [GO:0060052]; neuromuscular process controlling balance [GO:0050885]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of axonogenesis [GO:0050772]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein polymerization [GO:0051258]; regulation of axon diameter [GO:0031133]; regulation of synapse maturation [GO:0090128]; response to acrylamide [GO:1903937]; response to corticosterone [GO:0051412]; response to peptide hormone [GO:0043434]; response to sodium arsenite [GO:1903935]; response to toxic substance [GO:0009636]; retrograde axonal transport [GO:0008090]; spinal cord development [GO:0021510]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; cholinergic synapse [GO:0098981]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; intermediate filament [GO:0005882]; neurofilament [GO:0005883]; neuromuscular junction [GO:0031594]; postsynaptic intermediate filament cytoskeleton [GO:0099160]; presynaptic intermediate filament cytoskeleton [GO:0099182]; Schaffer collateral - CA1 synapse [GO:0098685]	identical protein binding [GO:0042802]; phospholipase binding [GO:0043274]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic intermediate filament cytoskeleton [GO:0099184]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; cholinergic synapse [GO:0098981]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; intermediate filament [GO:0005882]; neurofilament [GO:0005883]; neuromuscular junction [GO:0031594]; postsynaptic intermediate filament cytoskeleton [GO:0099160]; presynaptic intermediate filament cytoskeleton [GO:0099182]; Schaffer collateral - CA1 synapse [GO:0098685]; identical protein binding [GO:0042802]; phospholipase binding [GO:0043274]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic intermediate filament cytoskeleton [GO:0099184]; anterograde axonal transport [GO:0008089]; axonal transport of mitochondrion [GO:0019896]; axonogenesis [GO:0007409]; cerebral cortex development [GO:0021987]; hippocampus development [GO:0021766]; intermediate filament organization [GO:0045109]; intermediate filament polymerization or depolymerization [GO:0045105]; locomotion [GO:0040011]; microtubule cytoskeleton organization [GO:0000226]; motor neuron apoptotic process [GO:0097049]; negative regulation of motor neuron apoptotic process [GO:2000672]; neurofilament bundle assembly [GO:0033693]; neurofilament cytoskeleton organization [GO:0060052]; neuromuscular process controlling balance [GO:0050885]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of axonogenesis [GO:0050772]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein polymerization [GO:0051258]; regulation of axon diameter [GO:0031133]; regulation of synapse maturation [GO:0090128]; response to acrylamide [GO:1903937]; response to corticosterone [GO:0051412]; response to peptide hormone [GO:0043434]; response to sodium arsenite [GO:1903935]; response to toxic substance [GO:0009636]; retrograde axonal transport [GO:0008090]; spinal cord development [GO:0021510]	SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000250|UniProtKB:P08551}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P08551}.
P07197	reviewed	NFM_HUMAN	Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)	NEFM NEF3 NFM	Homo sapiens (Human)	916	FUNCTION: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}.		neurofilament bundle assembly [GO:0033693]	axon [GO:0030424]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; neurofibrillary tangle [GO:0097418]; neurofilament [GO:0005883]; postsynaptic intermediate filament cytoskeleton [GO:0099160]	microtubule binding [GO:0008017]; structural constituent of cytoskeleton [GO:0005200]	axon [GO:0030424]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; neurofibrillary tangle [GO:0097418]; neurofilament [GO:0005883]; postsynaptic intermediate filament cytoskeleton [GO:0099160]; microtubule binding [GO:0008017]; structural constituent of cytoskeleton [GO:0005200]; neurofilament bundle assembly [GO:0033693]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P08553}. Cell projection, axon {ECO:0000250|UniProtKB:P08553}.
P07199	reviewed	CENPB_HUMAN	Major centromere autoantigen B (Centromere protein B) (CENP-B)	CENPB	Homo sapiens (Human)	599	FUNCTION: Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). {ECO:0000269|PubMed:11726497, ECO:0000305}.			chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; satellite DNA binding [GO:0003696]; sequence-specific DNA binding [GO:0043565]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; satellite DNA binding [GO:0003696]; sequence-specific DNA binding [GO:0043565]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000255|PROSITE-ProRule:PRU00583, ECO:0000269|PubMed:18072184}. Chromosome, centromere {ECO:0000269|PubMed:18072184}.
P07202	reviewed	PERT_HUMAN	Thyroid peroxidase (TPO) (EC 1.11.1.8)	TPO	Homo sapiens (Human)	933	FUNCTION: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). {ECO:0000250|UniProtKB:P09933}.	MISCELLANEOUS: [Isoform 2]: Lacks exon 10. Found in normal thyroid tissues as well as Graves'tissues. Rapidly degraded after synthesis, does not reach the cell surface. Inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Lacks exon 16. Found in normal thyroid tissues as well as Graves'tissues. Active. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Lacks exon 14. Active. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Lacks exon 8. Does not fold correctly. Does not reach the cell surface. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Lacks exons 10, 12, 13, 14 and 16. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2-3]: Lacks exons 10 and 16. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2-4]: Lacks exons 10 and 14. {ECO:0000305}.	embryonic hemopoiesis [GO:0035162]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979]; thyroid hormone generation [GO:0006590]	cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; heme binding [GO:0020037]; iodide peroxidase activity [GO:0004447]; peroxidase activity [GO:0004601]	cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; heme binding [GO:0020037]; iodide peroxidase activity [GO:0004447]; peroxidase activity [GO:0004601]; embryonic hemopoiesis [GO:0035162]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979]; thyroid hormone generation [GO:0006590]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell surface.
P07203	reviewed	GPX1_HUMAN	Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase)	GPX1	Homo sapiens (Human)	203	FUNCTION: Protects the hemoglobin in erythrocytes from oxidative breakdown. In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism (PubMed:11115402). {ECO:0000269|PubMed:11115402}.		angiogenesis involved in wound healing [GO:0060055]; arachidonic acid metabolic process [GO:0019369]; biological process involved in interaction with symbiont [GO:0051702]; blood vessel endothelial cell migration [GO:0043534]; cell redox homeostasis [GO:0045454]; cellular response to glucose stimulus [GO:0071333]; cellular response to oxidative stress [GO:0034599]; endothelial cell development [GO:0001885]; epigenetic regulation of gene expression [GO:0040029]; fat cell differentiation [GO:0045444]; fibroblast proliferation [GO:0048144]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide catabolic process [GO:0042744]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; lipoxygenase pathway [GO:0019372]; myoblast differentiation [GO:0045445]; myoblast proliferation [GO:0051450]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; neuron apoptotic process [GO:0051402]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of supramolecular fiber organization [GO:1902905]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of proteasomal protein catabolic process [GO:0061136]; response to estradiol [GO:0032355]; response to folic acid [GO:0051593]; response to gamma radiation [GO:0010332]; response to hormone [GO:0009725]; response to hydrogen peroxide [GO:0042542]; response to hydroperoxide [GO:0033194]; response to nicotine [GO:0035094]; response to selenium ion [GO:0010269]; response to symbiotic bacterium [GO:0009609]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue regeneration [GO:0043403]; temperature homeostasis [GO:0001659]; triglyceride metabolic process [GO:0006641]; UV protection [GO:0009650]; vasodilation [GO:0042311]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	glutathione peroxidase activity [GO:0004602]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; glutathione peroxidase activity [GO:0004602]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066]; SH3 domain binding [GO:0017124]; angiogenesis involved in wound healing [GO:0060055]; arachidonic acid metabolic process [GO:0019369]; biological process involved in interaction with symbiont [GO:0051702]; blood vessel endothelial cell migration [GO:0043534]; cell redox homeostasis [GO:0045454]; cellular response to glucose stimulus [GO:0071333]; cellular response to oxidative stress [GO:0034599]; endothelial cell development [GO:0001885]; epigenetic regulation of gene expression [GO:0040029]; fat cell differentiation [GO:0045444]; fibroblast proliferation [GO:0048144]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide catabolic process [GO:0042744]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; lipoxygenase pathway [GO:0019372]; myoblast differentiation [GO:0045445]; myoblast proliferation [GO:0051450]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; neuron apoptotic process [GO:0051402]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of supramolecular fiber organization [GO:1902905]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of proteasomal protein catabolic process [GO:0061136]; response to estradiol [GO:0032355]; response to folic acid [GO:0051593]; response to gamma radiation [GO:0010332]; response to hormone [GO:0009725]; response to hydrogen peroxide [GO:0042542]; response to hydroperoxide [GO:0033194]; response to nicotine [GO:0035094]; response to selenium ion [GO:0010269]; response to symbiotic bacterium [GO:0009609]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue regeneration [GO:0043403]; temperature homeostasis [GO:0001659]; triglyceride metabolic process [GO:0006641]; UV protection [GO:0009650]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Cytoplasm.
P07204	reviewed	TRBM_HUMAN	Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141)	THBD THRM	Homo sapiens (Human)	575	FUNCTION: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.		blood coagulation [GO:0007596]; blood coagulation, common pathway [GO:0072377]; female pregnancy [GO:0007565]; negative regulation of blood coagulation [GO:0030195]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of platelet activation [GO:0010544]; proteolysis [GO:0006508]; response to cAMP [GO:0051591]; response to lipopolysaccharide [GO:0032496]; response to X-ray [GO:0010165]; zymogen activation [GO:0031638]	apicolateral plasma membrane [GO:0016327]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; serine-type endopeptidase complex [GO:1905370]; vacuolar membrane [GO:0005774]	calcium ion binding [GO:0005509]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	apicolateral plasma membrane [GO:0016327]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; serine-type endopeptidase complex [GO:1905370]; vacuolar membrane [GO:0005774]; calcium ion binding [GO:0005509]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; blood coagulation [GO:0007596]; blood coagulation, common pathway [GO:0072377]; female pregnancy [GO:0007565]; negative regulation of blood coagulation [GO:0030195]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of platelet activation [GO:0010544]; proteolysis [GO:0006508]; response to cAMP [GO:0051591]; response to lipopolysaccharide [GO:0032496]; response to X-ray [GO:0010165]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P07205	reviewed	PGK2_HUMAN	Phosphoglycerate kinase 2 (EC 2.7.2.3) (Phosphoglycerate kinase, testis specific)	PGK2 PGKB	Homo sapiens (Human)	417	FUNCTION: Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:P09041, ECO:0000269|PubMed:26677959}.		canonical glycolysis [GO:0061621]; flagellated sperm motility [GO:0030317]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; phosphorylation [GO:0016310]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]; canonical glycolysis [GO:0061621]; flagellated sperm motility [GO:0030317]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
P07225	reviewed	PROS_HUMAN	Vitamin K-dependent protein S	PROS1 PROS	Homo sapiens (Human)	676	FUNCTION: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.		blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]	blood microparticle [GO:0072562]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]	calcium ion binding [GO:0005509]; endopeptidase inhibitor activity [GO:0004866]	blood microparticle [GO:0072562]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; calcium ion binding [GO:0005509]; endopeptidase inhibitor activity [GO:0004866]; blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]	SUBCELLULAR LOCATION: Secreted.
P07237	reviewed	PDIA1_HUMAN	Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)	P4HB ERBA2L PDI PDIA1 PO4DB	Homo sapiens (Human)	508	FUNCTION: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}.	MISCELLANEOUS: Reduces and may activate fusogenic properties of HIV-1 gp120 surface protein, thereby enabling HIV-1 entry into the cell.	cellular response to hypoxia [GO:0071456]; cellular response to interleukin-7 [GO:0098761]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; insulin processing [GO:0030070]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; positive regulation of cell adhesion [GO:0045785]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of viral entry into host cell [GO:0046598]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; response to endoplasmic reticulum stress [GO:0034976]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; procollagen-proline 4-dioxygenase complex [GO:0016222]; protein-containing complex [GO:0032991]	actin binding [GO:0003779]; enzyme binding [GO:0019899]; integrin binding [GO:0005178]; procollagen-proline 4-dioxygenase activity [GO:0004656]; protein disulfide isomerase activity [GO:0003756]; protein heterodimerization activity [GO:0046982]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723]; thiol oxidase activity [GO:0016972]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; procollagen-proline 4-dioxygenase complex [GO:0016222]; protein-containing complex [GO:0032991]; actin binding [GO:0003779]; enzyme binding [GO:0019899]; integrin binding [GO:0005178]; procollagen-proline 4-dioxygenase activity [GO:0004656]; protein disulfide isomerase activity [GO:0003756]; protein heterodimerization activity [GO:0046982]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723]; thiol oxidase activity [GO:0016972]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-7 [GO:0098761]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; insulin processing [GO:0030070]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; positive regulation of cell adhesion [GO:0045785]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of viral entry into host cell [GO:0046598]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:32149426}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:23475612}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Cell membrane {ECO:0000269|PubMed:21670307}; Peripheral membrane protein {ECO:0000305}. Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces (PubMed:11181151). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:10636893). Colocalizes with MTTP in the endoplasmic reticulum (PubMed:23475612). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:11181151, ECO:0000269|PubMed:23475612, ECO:0000305}.
P07288	reviewed	KLK3_HUMAN	Prostate-specific antigen (PSA) (EC 3.4.21.77) (Gamma-seminoprotein) (Seminin) (Kallikrein-3) (P-30 antigen) (Semenogelase)	KLK3 APS	Homo sapiens (Human)	261	FUNCTION: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.		negative regulation of angiogenesis [GO:0016525]; positive regulation of antibacterial peptide production [GO:0002803]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]	endopeptidase activity [GO:0004175]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; endopeptidase activity [GO:0004175]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; negative regulation of angiogenesis [GO:0016525]; positive regulation of antibacterial peptide production [GO:0002803]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
P07305	reviewed	H10_HUMAN	Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed]	H1-0 H1F0 H1FV	Homo sapiens (Human)	194	FUNCTION: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.		chromosome condensation [GO:0030261]; heterochromatin formation [GO:0031507]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; positive regulation of transcription regulatory region DNA binding [GO:2000679]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; euchromatin [GO:0000791]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; euchromatin [GO:0000791]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]; chromosome condensation [GO:0030261]; heterochromatin formation [GO:0031507]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; positive regulation of transcription regulatory region DNA binding [GO:2000679]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:18993075}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:18993075}. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
P07306	reviewed	ASGR1_HUMAN	Asialoglycoprotein receptor 1 (ASGP-R 1) (ASGPR 1) (C-type lectin domain family 4 member H1) (Hepatic lectin H1) (HL-1)	ASGR1 CLEC4H1	Homo sapiens (Human)	291	FUNCTION: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.	MISCELLANEOUS: Calcium is required for ligand binding.	cellular response to extracellular stimulus [GO:0031668]; receptor-mediated endocytosis [GO:0006898]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	asialoglycoprotein receptor activity [GO:0004873]; fucose binding [GO:0042806]; identical protein binding [GO:0042802]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; asialoglycoprotein receptor activity [GO:0004873]; fucose binding [GO:0042806]; identical protein binding [GO:0042802]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]; cellular response to extracellular stimulus [GO:0031668]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: [Isoform H1a]: Membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Isoform H1b]: Secreted {ECO:0000269|PubMed:20886072}.
P07307	reviewed	ASGR2_HUMAN	Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2)	ASGR2 CLEC4H2	Homo sapiens (Human)	311	FUNCTION: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.	MISCELLANEOUS: Calcium is required for ligand binding.	cell surface receptor signaling pathway [GO:0007166]	endoplasmic reticulum quality control compartment [GO:0044322]; external side of plasma membrane [GO:0009897]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	asialoglycoprotein receptor activity [GO:0004873]; fucose binding [GO:0042806]; mannose binding [GO:0005537]	endoplasmic reticulum quality control compartment [GO:0044322]; external side of plasma membrane [GO:0009897]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; asialoglycoprotein receptor activity [GO:0004873]; fucose binding [GO:0042806]; mannose binding [GO:0005537]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
P07315	reviewed	CRGC_HUMAN	Gamma-crystallin C (Gamma-C-crystallin) (Gamma-crystallin 2-1) (Gamma-crystallin 3)	CRYGC CRYG3	Homo sapiens (Human)	174	FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.		lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	structural constituent of eye lens [GO:0005212]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; structural constituent of eye lens [GO:0005212]; lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]	
P07320	reviewed	CRGD_HUMAN	Gamma-crystallin D (Gamma-D-crystallin) (Gamma-crystallin 4)	CRYGD CRYG4	Homo sapiens (Human)	174	FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.		cellular response to reactive oxygen species [GO:0034614]; lens development in camera-type eye [GO:0002088]; lens fiber cell differentiation [GO:0070306]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	structural constituent of eye lens [GO:0005212]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; structural constituent of eye lens [GO:0005212]; cellular response to reactive oxygen species [GO:0034614]; lens development in camera-type eye [GO:0002088]; lens fiber cell differentiation [GO:0070306]; visual perception [GO:0007601]	
P07327	reviewed	ADH1A_HUMAN	Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase subunit alpha)	ADH1A ADH1	Homo sapiens (Human)	375	FUNCTION: Alcohol dehydrogenase (PubMed:2738060). Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate (PubMed:2738060). {ECO:0000269|PubMed:2738060}.	MISCELLANEOUS: There are 7 different ADH's isozymes in human: three belongs to class-I: ADH1A, ADH1B, and ADH1C, one to class-II: ADH4, one to class-III: ADH5, one to class-IV: ADH7 and one to class-V: ADH6.	alcohol metabolic process [GO:0006066]; ethanol oxidation [GO:0006069]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	alcohol dehydrogenase (NAD+) activity [GO:0004022]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; butanol dehydrogenase activity [GO:1990362]; NAD-retinol dehydrogenase activity [GO:0004745]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; alcohol dehydrogenase (NAD+) activity [GO:0004022]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; butanol dehydrogenase activity [GO:1990362]; NAD-retinol dehydrogenase activity [GO:0004745]; zinc ion binding [GO:0008270]; alcohol metabolic process [GO:0006066]; ethanol oxidation [GO:0006069]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]	SUBCELLULAR LOCATION: Cytoplasm.
P07332	reviewed	FES_HUMAN	Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)	FES FPS	Homo sapiens (Human)	822	FUNCTION: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}.	MISCELLANEOUS: Cellular homolog of retroviral oncogenes. In contrast to the viral oncoproteins, the kinase activity of cellular FSP/FES is tightly regulated, and the kinase is inactive in normal cells in the absence of activating stimuli (PubMed:15485904). {ECO:0000305|PubMed:15485904}.	cardiac muscle cell proliferation [GO:0060038]; cell adhesion [GO:0007155]; cellular response to vitamin D [GO:0071305]; centrosome cycle [GO:0007098]; chemotaxis [GO:0006935]; microtubule bundle formation [GO:0001578]; myoblast proliferation [GO:0051450]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of neuron projection development [GO:0010976]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of cell motility [GO:2000145]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of mast cell degranulation [GO:0043304]; regulation of vesicle-mediated transport [GO:0060627]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule cytoskeleton [GO:0015630]	ATP binding [GO:0005524]; immunoglobulin receptor binding [GO:0034987]; microtubule binding [GO:0008017]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol binding [GO:0035091]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule cytoskeleton [GO:0015630]; ATP binding [GO:0005524]; immunoglobulin receptor binding [GO:0034987]; microtubule binding [GO:0008017]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol binding [GO:0035091]; protein tyrosine kinase activity [GO:0004713]; cardiac muscle cell proliferation [GO:0060038]; cell adhesion [GO:0007155]; cellular response to vitamin D [GO:0071305]; centrosome cycle [GO:0007098]; chemotaxis [GO:0006935]; microtubule bundle formation [GO:0001578]; myoblast proliferation [GO:0051450]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of neuron projection development [GO:0010976]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of cell motility [GO:2000145]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of mast cell degranulation [GO:0043304]; regulation of vesicle-mediated transport [GO:0060627]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.
P07333	reviewed	CSF1R_HUMAN	Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)	CSF1R FMS	Homo sapiens (Human)	972	FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (PubMed:20504948, PubMed:30982609). Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages (PubMed:30982608). {ECO:0000269|PubMed:12882960, ECO:0000269|PubMed:15117969, ECO:0000269|PubMed:16170366, ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:16648572, ECO:0000269|PubMed:17121910, ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:18814279, ECO:0000269|PubMed:19193011, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061, ECO:0000269|PubMed:30982608, ECO:0000269|PubMed:30982609, ECO:0000269|PubMed:7683918}.		axon guidance [GO:0007411]; cell population proliferation [GO:0008283]; cell-cell junction maintenance [GO:0045217]; cellular response to cytokine stimulus [GO:0071345]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cytokine-mediated signaling pathway [GO:0019221]; forebrain neuron differentiation [GO:0021879]; hemopoiesis [GO:0030097]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage colony-stimulating factor signaling pathway [GO:0038145]; macrophage differentiation [GO:0030225]; mammary gland duct morphogenesis [GO:0060603]; microglial cell proliferation [GO:0061518]; monocyte differentiation [GO:0030224]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; olfactory bulb development [GO:0021772]; osteoclast differentiation [GO:0030316]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation by host of viral process [GO:0044794]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of cell shape [GO:0008360]; regulation of macrophage migration [GO:1905521]; regulation of MAPK cascade [GO:0043408]; response to ischemia [GO:0002931]; ruffle organization [GO:0031529]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cell surface [GO:0009986]; CSF1-CSF1R complex [GO:1990682]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; macrophage colony-stimulating factor receptor activity [GO:0005011]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]	cell surface [GO:0009986]; CSF1-CSF1R complex [GO:1990682]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; macrophage colony-stimulating factor receptor activity [GO:0005011]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; axon guidance [GO:0007411]; cell population proliferation [GO:0008283]; cell-cell junction maintenance [GO:0045217]; cellular response to cytokine stimulus [GO:0071345]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cytokine-mediated signaling pathway [GO:0019221]; forebrain neuron differentiation [GO:0021879]; hemopoiesis [GO:0030097]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage colony-stimulating factor signaling pathway [GO:0038145]; macrophage differentiation [GO:0030225]; mammary gland duct morphogenesis [GO:0060603]; microglial cell proliferation [GO:0061518]; monocyte differentiation [GO:0030224]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; olfactory bulb development [GO:0021772]; osteoclast differentiation [GO:0030316]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation by host of viral process [GO:0044794]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of cell shape [GO:0008360]; regulation of macrophage migration [GO:1905521]; regulation of MAPK cascade [GO:0043408]; response to ischemia [GO:0002931]; ruffle organization [GO:0031529]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P07339	reviewed	CATD_HUMAN	Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain]	CTSD CPSD	Homo sapiens (Human)	412	FUNCTION: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}.		antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; autophagosome assembly [GO:0000045]; insulin catabolic process [GO:1901143]; insulin receptor recycling [GO:0038020]; lipoprotein catabolic process [GO:0042159]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; proteolysis [GO:0006508]; regulation of establishment of protein localization [GO:0070201]	collagen-containing extracellular matrix [GO:0062023]; endosome lumen [GO:0031904]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane raft [GO:0045121]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	aspartic-type endopeptidase activity [GO:0004190]; aspartic-type peptidase activity [GO:0070001]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233]	collagen-containing extracellular matrix [GO:0062023]; endosome lumen [GO:0031904]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane raft [GO:0045121]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; aspartic-type endopeptidase activity [GO:0004190]; aspartic-type peptidase activity [GO:0070001]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; autophagosome assembly [GO:0000045]; insulin catabolic process [GO:1901143]; insulin receptor recycling [GO:0038020]; lipoprotein catabolic process [GO:0042159]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; proteolysis [GO:0006508]; regulation of establishment of protein localization [GO:0070201]	SUBCELLULAR LOCATION: Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). {ECO:0000269|PubMed:20551380}.
P07355	reviewed	ANXA2_HUMAN	Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	Homo sapiens (Human)	339	FUNCTION: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). {ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}.	MISCELLANEOUS: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.	angiogenesis [GO:0001525]; collagen fibril organization [GO:0030199]; fibrinolysis [GO:0042730]; membrane raft assembly [GO:0001765]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of receptor internalization [GO:0002091]; osteoclast development [GO:0036035]; positive regulation of exocytosis [GO:0045921]; positive regulation of low-density lipoprotein particle clearance [GO:1905581]; positive regulation of low-density lipoprotein particle receptor binding [GO:1905597]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of plasma membrane repair [GO:1905686]; positive regulation of plasminogen activation [GO:0010756]; positive regulation of receptor recycling [GO:0001921]; positive regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905602]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vacuole organization [GO:0044090]; positive regulation of vesicle fusion [GO:0031340]; regulation of neurogenesis [GO:0050767]; vesicle budding from membrane [GO:0006900]	adherens junction [GO:0005912]; AnxA2-p11 complex [GO:1990665]; azurophil granule lumen [GO:0035578]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; myelin sheath adaxonal region [GO:0035749]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; PCSK9-AnxA2 complex [GO:1990667]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; RNA polymerase II transcription regulator complex [GO:0090575]; sarcolemma [GO:0042383]; Schmidt-Lanterman incisure [GO:0043220]; vesicle [GO:0031982]	cadherin binding involved in cell-cell adhesion [GO:0098641]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; phospholipase A2 inhibitor activity [GO:0019834]; protease binding [GO:0002020]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548]; serine-type endopeptidase inhibitor activity [GO:0004867]; virion binding [GO:0046790]	adherens junction [GO:0005912]; AnxA2-p11 complex [GO:1990665]; azurophil granule lumen [GO:0035578]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; myelin sheath adaxonal region [GO:0035749]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; PCSK9-AnxA2 complex [GO:1990667]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; RNA polymerase II transcription regulator complex [GO:0090575]; sarcolemma [GO:0042383]; Schmidt-Lanterman incisure [GO:0043220]; vesicle [GO:0031982]; cadherin binding involved in cell-cell adhesion [GO:0098641]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; phospholipase A2 inhibitor activity [GO:0019834]; protease binding [GO:0002020]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548]; serine-type endopeptidase inhibitor activity [GO:0004867]; virion binding [GO:0046790]; angiogenesis [GO:0001525]; collagen fibril organization [GO:0030199]; fibrinolysis [GO:0042730]; membrane raft assembly [GO:0001765]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of receptor internalization [GO:0002091]; osteoclast development [GO:0036035]; positive regulation of exocytosis [GO:0045921]; positive regulation of low-density lipoprotein particle clearance [GO:1905581]; positive regulation of low-density lipoprotein particle receptor binding [GO:1905597]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of plasma membrane repair [GO:1905686]; positive regulation of plasminogen activation [GO:0010756]; positive regulation of receptor recycling [GO:0001921]; positive regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905602]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vacuole organization [GO:0044090]; positive regulation of vesicle fusion [GO:0031340]; regulation of neurogenesis [GO:0050767]; vesicle budding from membrane [GO:0006900]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
P07357	reviewed	CO8A_HUMAN	Complement component C8 alpha chain (Complement component 8 subunit alpha)	C8A	Homo sapiens (Human)	584	FUNCTION: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. {ECO:0000269|PubMed:17872444, ECO:0000269|PubMed:7440581}.		complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886]	complement binding [GO:0001848]; protein-containing complex binding [GO:0044877]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886]; complement binding [GO:0001848]; protein-containing complex binding [GO:0044877]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]	SUBCELLULAR LOCATION: Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells.
P07358	reviewed	CO8B_HUMAN	Complement component C8 beta chain (Complement component 8 subunit beta)	C8B	Homo sapiens (Human)	591	FUNCTION: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.		complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886]	protein-containing complex binding [GO:0044877]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886]; protein-containing complex binding [GO:0044877]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]	SUBCELLULAR LOCATION: Secreted.
P07359	reviewed	GP1BA_HUMAN	Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (Antigen CD42b-alpha) (CD antigen CD42b) [Cleaved into: Glycocalicin]	GP1BA	Homo sapiens (Human)	652	FUNCTION: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.	MISCELLANEOUS: Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.	blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; fibrinolysis [GO:0042730]; megakaryocyte development [GO:0035855]; platelet activation [GO:0030168]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of platelet activation [GO:0010572]; regulation of blood coagulation [GO:0030193]; release of sequestered calcium ion into cytosol [GO:0051209]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glycoprotein Ib-IX-V complex [GO:1990779]; membrane [GO:0016020]; plasma membrane [GO:0005886]	thrombin-activated receptor activity [GO:0015057]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glycoprotein Ib-IX-V complex [GO:1990779]; membrane [GO:0016020]; plasma membrane [GO:0005886]; thrombin-activated receptor activity [GO:0015057]; blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; fibrinolysis [GO:0042730]; megakaryocyte development [GO:0035855]; platelet activation [GO:0030168]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of platelet activation [GO:0010572]; regulation of blood coagulation [GO:0030193]; release of sequestered calcium ion into cytosol [GO:0051209]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P07360	reviewed	CO8G_HUMAN	Complement component C8 gamma chain	C8G	Homo sapiens (Human)	202	FUNCTION: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.		complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886]	complement binding [GO:0001848]; protein-containing complex binding [GO:0044877]; retinol binding [GO:0019841]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886]; complement binding [GO:0001848]; protein-containing complex binding [GO:0044877]; retinol binding [GO:0019841]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]	SUBCELLULAR LOCATION: Secreted.
P07384	reviewed	CAN1_HUMAN	Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)	CAPN1 CANPL1 PIG30	Homo sapiens (Human)	714	FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}.		mammary gland involution [GO:0060056]; positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; receptor catabolic process [GO:0032801]; regulation of catalytic activity [GO:0050790]; regulation of macroautophagy [GO:0016241]; regulation of NMDA receptor activity [GO:2000310]; self proteolysis [GO:0097264]	calpain complex [GO:0110158]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; peptidase activity [GO:0008233]	calpain complex [GO:0110158]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; peptidase activity [GO:0008233]; mammary gland involution [GO:0060056]; positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; receptor catabolic process [GO:0032801]; regulation of catalytic activity [GO:0050790]; regulation of macroautophagy [GO:0016241]; regulation of NMDA receptor activity [GO:2000310]; self proteolysis [GO:0097264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:8769305}. Cell membrane {ECO:0000269|PubMed:8769305}. Note=Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719). {ECO:0000269|PubMed:21531719}.
P07437	reviewed	TBB5_HUMAN	Tubulin beta chain (Tubulin beta-5 chain)	TUBB TUBB5 OK/SW-cl.56	Homo sapiens (Human)	444	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		cell division [GO:0051301]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267]; odontoblast differentiation [GO:0071895]; regulation of synapse organization [GO:0050807]; spindle assembly [GO:0051225]	azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intercellular bridge [GO:0045171]; membrane raft [GO:0045121]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nuclear envelope lumen [GO:0005641]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; MHC class I protein binding [GO:0042288]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625]	azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intercellular bridge [GO:0045171]; membrane raft [GO:0045121]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nuclear envelope lumen [GO:0005641]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; MHC class I protein binding [GO:0042288]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625]; cell division [GO:0051301]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267]; odontoblast differentiation [GO:0071895]; regulation of synapse organization [GO:0050807]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26637975}.
P07438	reviewed	MT1B_HUMAN	Metallothionein-1B (MT-1B) (Metallothionein-IB) (MT-IB)	MT1B MT1Q	Homo sapiens (Human)	61	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.		cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	
P07451	reviewed	CAH3_HUMAN	Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III)	CA3	Homo sapiens (Human)	260	FUNCTION: Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}.		one-carbon metabolic process [GO:0006730]; response to bacterium [GO:0009617]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	carbonate dehydratase activity [GO:0004089]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; carbonate dehydratase activity [GO:0004089]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270]; one-carbon metabolic process [GO:0006730]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18618712}.
P07476	reviewed	INVO_HUMAN	Involucrin	IVL	Homo sapiens (Human)	585	FUNCTION: Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.		isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine [GO:0018153]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; response to UV-B [GO:0010224]	centrosome [GO:0005813]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]		centrosome [GO:0005813]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine [GO:0018153]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; response to UV-B [GO:0010224]	SUBCELLULAR LOCATION: Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.
P07477	reviewed	TRY1_HUMAN	Serine protease 1 (EC 3.4.21.4) (Anionic trypsin I) (Anionic trypsin-I) (Beta-trypsin) (Cationic trypsinogen) (Pretrypsinogen I) (Trypsin I) (Trypsin-1) [Cleaved into: Alpha-trypsin chain 1; Alpha-trypsin chain 2]	PRSS1 TRP1 TRY1 TRYP1	Homo sapiens (Human)	247	FUNCTION: Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates. {ECO:0000269|PubMed:7945238}.		digestion [GO:0007586]; extracellular matrix disassembly [GO:0022617]; proteolysis [GO:0006508]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; digestion [GO:0007586]; extracellular matrix disassembly [GO:0022617]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P07478	reviewed	TRY2_HUMAN	Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II)	PRSS2 TRY2 TRYP2	Homo sapiens (Human)	247	FUNCTION: In the ileum, may be involved in defensin processing, including DEFA5. {ECO:0000269|PubMed:12021776}.		antimicrobial humoral response [GO:0019730]; collagen catabolic process [GO:0030574]; digestion [GO:0007586]; extracellular matrix disassembly [GO:0022617]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; proteolysis [GO:0006508]	azurophil granule lumen [GO:0035578]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	azurophil granule lumen [GO:0035578]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; antimicrobial humoral response [GO:0019730]; collagen catabolic process [GO:0030574]; digestion [GO:0007586]; extracellular matrix disassembly [GO:0022617]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P07492	reviewed	GRP_HUMAN	Gastrin-releasing peptide (GRP) [Cleaved into: Neuromedin-C (GRP-10) (GRP18-27)]	GRP	Homo sapiens (Human)	148	FUNCTION: Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (By similarity). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). {ECO:0000250|UniProtKB:P24393, ECO:0000250|UniProtKB:P63153, ECO:0000250|UniProtKB:Q8R1I2}.; FUNCTION: [Neuromedin-C]: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation. {ECO:0000250|UniProtKB:Q8R1I2}.		mast cell degranulation [GO:0043303]; negative regulation of voltage-gated potassium channel activity [GO:1903817]; negative regulation of voltage-gated sodium channel activity [GO:1905151]; neuropeptide signaling pathway [GO:0007218]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of respiratory gaseous exchange [GO:1903942]; psychomotor behavior [GO:0036343]; response to external biotic stimulus [GO:0043207]; signal transduction [GO:0007165]; social behavior [GO:0035176]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005]; neuronal dense core vesicle [GO:0098992]; secretory granule lumen [GO:0034774]	neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005]; neuronal dense core vesicle [GO:0098992]; secretory granule lumen [GO:0034774]; neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102]; mast cell degranulation [GO:0043303]; negative regulation of voltage-gated potassium channel activity [GO:1903817]; negative regulation of voltage-gated sodium channel activity [GO:1905151]; neuropeptide signaling pathway [GO:0007218]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of respiratory gaseous exchange [GO:1903942]; psychomotor behavior [GO:0036343]; response to external biotic stimulus [GO:0043207]; signal transduction [GO:0007165]; social behavior [GO:0035176]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3211139}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q863C3}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q8R1I2}. Note=In neurons of the retrotrapezoid nucleus/parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. {ECO:0000250|UniProtKB:Q8R1I2}.
P07498	reviewed	CASK_HUMAN	Kappa-casein	CSN3 CASK CSN10 CSNK	Homo sapiens (Human)	182	FUNCTION: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.		lactation [GO:0007595]; protein stabilization [GO:0050821]	extracellular region [GO:0005576]; extracellular space [GO:0005615]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; lactation [GO:0007595]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Secreted.
P07510	reviewed	ACHG_HUMAN	Acetylcholine receptor subunit gamma	CHRNG ACHRG	Homo sapiens (Human)	517	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.		muscle contraction [GO:0006936]; signal transduction [GO:0007165]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]; muscle contraction [GO:0006936]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
P07550	reviewed	ADRB2_HUMAN	Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)	ADRB2 ADRB2R B2AR	Homo sapiens (Human)	413	FUNCTION: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. {ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}.		activation of adenylate cyclase activity [GO:0007190]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; adrenergic receptor signaling pathway [GO:0071875]; bone resorption [GO:0045453]; brown fat cell differentiation [GO:0050873]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; desensitization of G protein-coupled receptor signaling pathway by arrestin [GO:0002032]; diet induced thermogenesis [GO:0002024]; endosome to lysosome transport [GO:0008333]; heat generation [GO:0031649]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of smooth muscle contraction [GO:0045986]; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002025]; positive regulation of AMPA receptor activity [GO:2000969]; positive regulation of autophagosome maturation [GO:1901098]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of lipophagy [GO:1904504]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mini excitatory postsynaptic potential [GO:0061885]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor-mediated endocytosis [GO:0006898]; regulation of sodium ion transport [GO:0002028]; response to cold [GO:0009409]; response to psychosocial stress [GO:1990911]; smooth muscle contraction [GO:0006939]; transcription by RNA polymerase II [GO:0006366]	apical plasma membrane [GO:0016324]; clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane [GO:0016020]; neuronal dense core vesicle [GO:0098992]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	adenylate cyclase binding [GO:0008179]; amyloid-beta binding [GO:0001540]; beta2-adrenergic receptor activity [GO:0004941]; identical protein binding [GO:0042802]; norepinephrine binding [GO:0051380]; potassium channel regulator activity [GO:0015459]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	apical plasma membrane [GO:0016324]; clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane [GO:0016020]; neuronal dense core vesicle [GO:0098992]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; adenylate cyclase binding [GO:0008179]; amyloid-beta binding [GO:0001540]; beta2-adrenergic receptor activity [GO:0004941]; identical protein binding [GO:0042802]; norepinephrine binding [GO:0051380]; potassium channel regulator activity [GO:0015459]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; activation of adenylate cyclase activity [GO:0007190]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; adrenergic receptor signaling pathway [GO:0071875]; bone resorption [GO:0045453]; brown fat cell differentiation [GO:0050873]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; desensitization of G protein-coupled receptor signaling pathway by arrestin [GO:0002032]; diet induced thermogenesis [GO:0002024]; endosome to lysosome transport [GO:0008333]; heat generation [GO:0031649]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of smooth muscle contraction [GO:0045986]; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002025]; positive regulation of AMPA receptor activity [GO:2000969]; positive regulation of autophagosome maturation [GO:1901098]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of lipophagy [GO:1904504]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mini excitatory postsynaptic potential [GO:0061885]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor-mediated endocytosis [GO:0006898]; regulation of sodium ion transport [GO:0002028]; response to cold [GO:0009409]; response to psychosocial stress [GO:1990911]; smooth muscle contraction [GO:0006939]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23166351, ECO:0000269|PubMed:25220262, ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}; Multi-pass membrane protein {ECO:0000269|PubMed:19584355}. Early endosome {ECO:0000269|PubMed:20559325}. Golgi apparatus {ECO:0000269|PubMed:27481942}. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). {ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:27481942}.
P07585	reviewed	PGS2_HUMAN	Decorin (Bone proteoglycan II) (PG-S2) (PG40)	DCN SLRR1B	Homo sapiens (Human)	359	FUNCTION: May affect the rate of fibrils formation.		animal organ morphogenesis [GO:0009887]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of autophagy [GO:0010508]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]	extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; glycosaminoglycan binding [GO:0005539]; RNA binding [GO:0003723]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; glycosaminoglycan binding [GO:0005539]; RNA binding [GO:0003723]; animal organ morphogenesis [GO:0009887]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of autophagy [GO:0010508]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313}.
P07602	reviewed	SAP_HUMAN	Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]	PSAP GLBA SAP1	Homo sapiens (Human)	524	FUNCTION: Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.; FUNCTION: Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.; FUNCTION: Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).; FUNCTION: [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. {ECO:0000250|UniProtKB:Q61207, ECO:0000269|PubMed:10383054}.; FUNCTION: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.	MISCELLANEOUS: Saposin-B co-purifies with 1 molecule of phosphatidylethanolamine.	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; ganglioside GM1 transport to membrane [GO:1905572]; lysosomal transport [GO:0007041]; positive regulation of beta-galactosidase activity [GO:1903771]; prostate gland growth [GO:0060736]; regulation of autophagy [GO:0010506]; regulation of lipid metabolic process [GO:0019216]; sphingolipid metabolic process [GO:0006665]	azurophil granule membrane [GO:0035577]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	enzyme activator activity [GO:0008047]; ganglioside GM1 binding [GO:1905573]; ganglioside GM2 binding [GO:1905574]; ganglioside GM3 binding [GO:1905575]; ganglioside GP1c binding [GO:1905577]; ganglioside GT1b binding [GO:1905576]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]	azurophil granule membrane [GO:0035577]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; enzyme activator activity [GO:0008047]; ganglioside GM1 binding [GO:1905573]; ganglioside GM2 binding [GO:1905574]; ganglioside GM3 binding [GO:1905575]; ganglioside GP1c binding [GO:1905577]; ganglioside GT1b binding [GO:1905576]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; ganglioside GM1 transport to membrane [GO:1905572]; lysosomal transport [GO:0007041]; positive regulation of beta-galactosidase activity [GO:1903771]; prostate gland growth [GO:0060736]; regulation of autophagy [GO:0010506]; regulation of lipid metabolic process [GO:0019216]; sphingolipid metabolic process [GO:0006665]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:21835174, ECO:0000269|PubMed:22431521}.; SUBCELLULAR LOCATION: [Prosaposin]: Secreted {ECO:0000250|UniProtKB:Q61207}. Note=Secreted as a fully glycosylated 70 kDa protein composed of complex glycans. {ECO:0000250|UniProtKB:Q61207}.
P07686	reviewed	HEXB_HUMAN	Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]	HEXB HCC7	Homo sapiens (Human)	556	FUNCTION: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:9694901, PubMed:8672428, PubMed:8123671). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:9694901, PubMed:8672428, PubMed:8123671). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity). {ECO:0000250|UniProtKB:P20060, ECO:0000269|PubMed:11707436, ECO:0000269|PubMed:8123671, ECO:0000269|PubMed:8672428, ECO:0000269|PubMed:9694901}.		astrocyte cell migration [GO:0043615]; chondroitin sulfate catabolic process [GO:0030207]; dermatan sulfate catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; intracellular calcium ion homeostasis [GO:0006874]; lipid storage [GO:0019915]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; maintenance of location in cell [GO:0051651]; male courtship behavior [GO:0008049]; myelination [GO:0042552]; neuromuscular process controlling balance [GO:0050885]; neuron cellular homeostasis [GO:0070050]; oligosaccharide catabolic process [GO:0009313]; oogenesis [GO:0048477]; penetration of zona pellucida [GO:0007341]; phospholipid biosynthetic process [GO:0008654]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]	acrosomal vesicle [GO:0001669]; azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; beta-N-acetylhexosaminidase complex [GO:1905379]; cortical granule [GO:0060473]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]	acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylhexosaminidase activity [GO:0004563]; identical protein binding [GO:0042802]; N-acetyl-beta-D-galactosaminidase activity [GO:0102148]	acrosomal vesicle [GO:0001669]; azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; beta-N-acetylhexosaminidase complex [GO:1905379]; cortical granule [GO:0060473]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylhexosaminidase activity [GO:0004563]; identical protein binding [GO:0042802]; N-acetyl-beta-D-galactosaminidase activity [GO:0102148]; astrocyte cell migration [GO:0043615]; chondroitin sulfate catabolic process [GO:0030207]; dermatan sulfate catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; intracellular calcium ion homeostasis [GO:0006874]; lipid storage [GO:0019915]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; maintenance of location in cell [GO:0051651]; male courtship behavior [GO:0008049]; myelination [GO:0042552]; neuromuscular process controlling balance [GO:0050885]; neuron cellular homeostasis [GO:0070050]; oligosaccharide catabolic process [GO:0009313]; oogenesis [GO:0048477]; penetration of zona pellucida [GO:0007341]; phospholipid biosynthetic process [GO:0008654]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:9694901}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:P20060}.
P07711	reviewed	CATL1_HUMAN	Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain]	CTSL CTSL1	Homo sapiens (Human)	333	FUNCTION: Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells (By similarity). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (PubMed:10716919). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity). {ECO:0000250|UniProtKB:P06797, ECO:0000250|UniProtKB:P07154, ECO:0000250|UniProtKB:P25975, ECO:0000269|PubMed:10716919, ECO:0000305}.; FUNCTION: (Microbial infection) In cells lacking TMPRSS2 expression, facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via a slow acid-activated route with the proteolysis of coronavirus spike (S) glycoproteins in lysosome for entry into host cell (PubMed:32142651, PubMed:32221306, PubMed:16339146, PubMed:18562523). Proteolysis within lysosomes is sufficient to activate membrane fusion by coronaviruses SARS-CoV and EMC (HCoV-EMC) S as well as Zaire ebolavirus glycoproteins (PubMed:16081529, PubMed:26953343, PubMed:18562523). {ECO:0000269|PubMed:16081529, ECO:0000269|PubMed:16339146, ECO:0000269|PubMed:18562523, ECO:0000269|PubMed:26953343, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32221306, ECO:0000269|PubMed:32855215}.; FUNCTION: [Isoform 2]: Functions in the regulation of cell cycle progression through proteolytic processing of the CUX1 transcription factor (PubMed:15099520). Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and localize to the nucleus where they cleave the CUX1 transcription factor and modify its DNA binding properties (PubMed:15099520). {ECO:0000269|PubMed:15099520}.		adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen [GO:0048002]; CD4-positive, alpha-beta T cell lineage commitment [GO:0043373]; cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; elastin catabolic process [GO:0060309]; enkephalin processing [GO:0034230]; fusion of virus membrane with host endosome membrane [GO:0039654]; fusion of virus membrane with host plasma membrane [GO:0019064]; immune response [GO:0006955]; macrophage apoptotic process [GO:0071888]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; viral entry into host cell [GO:0046718]; zymogen activation [GO:0031638]	apical plasma membrane [GO:0016324]; chromaffin granule [GO:0042583]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle lumen [GO:0071682]; endolysosome lumen [GO:0036021]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	collagen binding [GO:0005518]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; fibronectin binding [GO:0001968]; histone binding [GO:0042393]; proteoglycan binding [GO:0043394]; serpin family protein binding [GO:0097655]	apical plasma membrane [GO:0016324]; chromaffin granule [GO:0042583]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle lumen [GO:0071682]; endolysosome lumen [GO:0036021]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; collagen binding [GO:0005518]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; fibronectin binding [GO:0001968]; histone binding [GO:0042393]; proteoglycan binding [GO:0043394]; serpin family protein binding [GO:0097655]; adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen [GO:0048002]; CD4-positive, alpha-beta T cell lineage commitment [GO:0043373]; cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; elastin catabolic process [GO:0060309]; enkephalin processing [GO:0034230]; fusion of virus membrane with host endosome membrane [GO:0039654]; fusion of virus membrane with host plasma membrane [GO:0019064]; immune response [GO:0006955]; macrophage apoptotic process [GO:0071888]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; viral entry into host cell [GO:0046718]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P06797}. Apical cell membrane {ECO:0000250|UniProtKB:P06797}; Peripheral membrane protein {ECO:0000250|UniProtKB:P06797}; Extracellular side {ECO:0000250|UniProtKB:P06797}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250|UniProtKB:P25975}. Secreted, extracellular space {ECO:0000250|UniProtKB:P06797}. Secreted {ECO:0000250|UniProtKB:P06797}. Note=Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. {ECO:0000250|UniProtKB:P06797}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:15099520}. Note=Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and do not transit through the endoplasmic reticulum to localize to the nucleus (PubMed:15099520). Nuclear location varies during the cell cycle, with higher levels during S phase (PubMed:15099520). {ECO:0000269|PubMed:15099520}.
P07737	reviewed	PROF1_HUMAN	Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)	PFN1	Homo sapiens (Human)	140	FUNCTION: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}.		actin cytoskeleton organization [GO:0030036]; modification of postsynaptic actin cytoskeleton [GO:0098885]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ruffle assembly [GO:1900029]; protein stabilization [GO:0050821]; regulation of actin filament polymerization [GO:0030833]; regulation of transcription by RNA polymerase II [GO:0006357]; synapse maturation [GO:0060074]	blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634]	actin binding [GO:0003779]; actin monomer binding [GO:0003785]; adenyl-nucleotide exchange factor activity [GO:0000774]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphotyrosine residue binding [GO:0001784]; proline-rich region binding [GO:0070064]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]	blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634]; actin binding [GO:0003779]; actin monomer binding [GO:0003785]; adenyl-nucleotide exchange factor activity [GO:0000774]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphotyrosine residue binding [GO:0001784]; proline-rich region binding [GO:0070064]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; modification of postsynaptic actin cytoskeleton [GO:0098885]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ruffle assembly [GO:1900029]; protein stabilization [GO:0050821]; regulation of actin filament polymerization [GO:0030833]; regulation of transcription by RNA polymerase II [GO:0006357]; synapse maturation [GO:0060074]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P07738	reviewed	PMGE_HUMAN	Bisphosphoglycerate mutase (BPGM) (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (EC 5.4.2.11) (2,3-diphosphoglycerate mutase) (DPGM) (BPG-dependent PGAM)	BPGM	Homo sapiens (Human)	259	FUNCTION: Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. {ECO:0000269|PubMed:21045285}.		carbohydrate derivative catabolic process [GO:1901136]; carbohydrate metabolic process [GO:0005975]; defense response to protozoan [GO:0042832]; erythrocyte development [GO:0048821]; establishment of blood-brain barrier [GO:0060856]; glycolytic process [GO:0006096]; neuroinflammatory response [GO:0150076]; nucleoside phosphate metabolic process [GO:0006753]; oxygen transport [GO:0015671]; respiratory gaseous exchange by respiratory system [GO:0007585]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]; carbohydrate derivative catabolic process [GO:1901136]; carbohydrate metabolic process [GO:0005975]; defense response to protozoan [GO:0042832]; erythrocyte development [GO:0048821]; establishment of blood-brain barrier [GO:0060856]; glycolytic process [GO:0006096]; neuroinflammatory response [GO:0150076]; nucleoside phosphate metabolic process [GO:0006753]; oxygen transport [GO:0015671]; respiratory gaseous exchange by respiratory system [GO:0007585]	
P07741	reviewed	APT_HUMAN	Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7)	APRT	Homo sapiens (Human)	180	FUNCTION: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. {ECO:0000269|PubMed:15196008}.		adenine salvage [GO:0006168]; AMP salvage [GO:0044209]; GMP salvage [GO:0032263]; grooming behavior [GO:0007625]; IMP salvage [GO:0032264]; purine ribonucleoside salvage [GO:0006166]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774]	adenine binding [GO:0002055]; adenine phosphoribosyltransferase activity [GO:0003999]; AMP binding [GO:0016208]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774]; adenine binding [GO:0002055]; adenine phosphoribosyltransferase activity [GO:0003999]; AMP binding [GO:0016208]; adenine salvage [GO:0006168]; AMP salvage [GO:0044209]; GMP salvage [GO:0032263]; grooming behavior [GO:0007625]; IMP salvage [GO:0032264]; purine ribonucleoside salvage [GO:0006166]	SUBCELLULAR LOCATION: Cytoplasm.
P07766	reviewed	CD3E_HUMAN	T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)	CD3E T3E	Homo sapiens (Human)	207	FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128). {ECO:0000269|PubMed:10384095, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:15546002, ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:26507128, ECO:0000269|PubMed:8490660}.		adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; apoptotic signaling pathway [GO:0097190]; calcium-mediated signaling [GO:0019722]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell surface receptor signaling pathway [GO:0007166]; cerebellum development [GO:0021549]; dendrite development [GO:0016358]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-delta T cell activation [GO:0046629]; negative regulation of gene expression [GO:0010629]; negative regulation of smoothened signaling pathway [GO:0045879]; negative thymic T cell selection [GO:0045060]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of T cell anergy [GO:0002669]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]; positive thymic T cell selection [GO:0045059]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; signal complex assembly [GO:0007172]; smoothened signaling pathway [GO:0007224]; T cell activation [GO:0042110]; T cell anergy [GO:0002870]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	alpha-beta T cell receptor complex [GO:0042105]; cell body [GO:0044297]; cell-cell junction [GO:0005911]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; gamma-delta T cell receptor complex [GO:0042106]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; signaling receptor complex adaptor activity [GO:0030159]; T cell receptor binding [GO:0042608]; transmembrane signaling receptor activity [GO:0004888]	alpha-beta T cell receptor complex [GO:0042105]; cell body [GO:0044297]; cell-cell junction [GO:0005911]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; gamma-delta T cell receptor complex [GO:0042106]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; signaling receptor complex adaptor activity [GO:0030159]; T cell receptor binding [GO:0042608]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; apoptotic signaling pathway [GO:0097190]; calcium-mediated signaling [GO:0019722]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell surface receptor signaling pathway [GO:0007166]; cerebellum development [GO:0021549]; dendrite development [GO:0016358]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-delta T cell activation [GO:0046629]; negative regulation of gene expression [GO:0010629]; negative regulation of smoothened signaling pathway [GO:0045879]; negative thymic T cell selection [GO:0045060]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of T cell anergy [GO:0002669]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]; positive thymic T cell selection [GO:0045059]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; signal complex assembly [GO:0007172]; smoothened signaling pathway [GO:0007224]; T cell activation [GO:0042110]; T cell anergy [GO:0002870]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10384095, ECO:0000269|PubMed:15294938}; Single-pass type I membrane protein {ECO:0000305}.
P07814	reviewed	SYEP_HUMAN	Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)]	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	Homo sapiens (Human)	1512	FUNCTION: Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (PubMed:1756734, PubMed:24100331, PubMed:23263184). The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex and recruits it to the GAIT complex that binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin), suppressing their translation. Interferon-gamma can therefore redirect, in specific cells, the EPRS1 function from protein synthesis to translation inhibition (PubMed:15479637, PubMed:23071094). Also functions as an effector of the mTORC1 signaling pathway by promoting, through SLC27A1, the uptake of long-chain fatty acid by adipocytes. Thereby, it also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:1756734, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239}.		cellular response to insulin stimulus [GO:0032869]; cellular response to type II interferon [GO:0071346]; glutamyl-tRNA aminoacylation [GO:0006424]; negative regulation of translation [GO:0017148]; prolyl-tRNA aminoacylation [GO:0006433]; protein-containing complex assembly [GO:0065003]; regulation of long-chain fatty acid import into cell [GO:0140212]; tRNA aminoacylation for protein translation [GO:0006418]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GAIT complex [GO:0097452]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]	ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; proline-tRNA ligase activity [GO:0004827]; protein homodimerization activity [GO:0042803]; RNA stem-loop binding [GO:0035613]; zinc ion binding [GO:0008270]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GAIT complex [GO:0097452]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; proline-tRNA ligase activity [GO:0004827]; protein homodimerization activity [GO:0042803]; RNA stem-loop binding [GO:0035613]; zinc ion binding [GO:0008270]; cellular response to insulin stimulus [GO:0032869]; cellular response to type II interferon [GO:0071346]; glutamyl-tRNA aminoacylation [GO:0006424]; negative regulation of translation [GO:0017148]; prolyl-tRNA aminoacylation [GO:0006433]; protein-containing complex assembly [GO:0065003]; regulation of long-chain fatty acid import into cell [GO:0140212]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:19289464}. Membrane {ECO:0000269|PubMed:28178239}; Peripheral membrane protein {ECO:0000305|PubMed:19289464, ECO:0000305|PubMed:28178239}. Note=Translocates from cytosol to membranes upon phosphorylation at Ser-999. {ECO:0000269|PubMed:19289464, ECO:0000269|PubMed:28178239}.
P07858	reviewed	CATB_HUMAN	Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]	CTSB CPSB	Homo sapiens (Human)	339	FUNCTION: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:12220505, ECO:0000269|PubMed:3972105}.		cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; decidualization [GO:0046697]; epithelial cell differentiation [GO:0030855]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; thyroid hormone generation [GO:0006590]; viral entry into host cell [GO:0046718]	apical plasma membrane [GO:0016324]; collagen-containing extracellular matrix [GO:0062023]; endolysosome lumen [GO:0036021]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosome [GO:0005764]; melanosome [GO:0042470]; peptidase inhibitor complex [GO:1904090]; perinuclear region of cytoplasm [GO:0048471]	collagen binding [GO:0005518]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; peptidase activity [GO:0008233]; proteoglycan binding [GO:0043394]	apical plasma membrane [GO:0016324]; collagen-containing extracellular matrix [GO:0062023]; endolysosome lumen [GO:0036021]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosome [GO:0005764]; melanosome [GO:0042470]; peptidase inhibitor complex [GO:1904090]; perinuclear region of cytoplasm [GO:0048471]; collagen binding [GO:0005518]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; peptidase activity [GO:0008233]; proteoglycan binding [GO:0043394]; cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; decidualization [GO:0046697]; epithelial cell differentiation [GO:0030855]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; thyroid hormone generation [GO:0006590]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:16733801}. Melanosome {ECO:0000269|PubMed:17081065}. Secreted, extracellular space {ECO:0000250|UniProtKB:A1E295}. Apical cell membrane {ECO:0000250|UniProtKB:P10605}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10605}; Extracellular side {ECO:0000250|UniProtKB:P10605}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity). {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:17081065}.
P07864	reviewed	LDHC_HUMAN	L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X)	LDHC LDH3 LDHX	Homo sapiens (Human)	332	FUNCTION: Possible role in sperm motility.		ATP biosynthetic process [GO:0006754]; flagellated sperm motility [GO:0030317]; lactate biosynthetic process from pyruvate [GO:0019244]; lactate metabolic process [GO:0006089]; lactate oxidation [GO:0019516]; pyruvate catabolic process [GO:0042867]; pyruvate metabolic process [GO:0006090]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204]	L-lactate dehydrogenase activity [GO:0004459]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204]; L-lactate dehydrogenase activity [GO:0004459]; ATP biosynthetic process [GO:0006754]; flagellated sperm motility [GO:0030317]; lactate biosynthetic process from pyruvate [GO:0019244]; lactate metabolic process [GO:0006089]; lactate oxidation [GO:0019516]; pyruvate catabolic process [GO:0042867]; pyruvate metabolic process [GO:0006090]	SUBCELLULAR LOCATION: Cytoplasm.
P07900	reviewed	HS90A_HUMAN	Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)	HSP90AA1 HSP90A HSPC1 HSPCA	Homo sapiens (Human)	732	FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155, PubMed:12526792). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}.		activation of innate immune response [GO:0002218]; axon extension [GO:0048675]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to heat [GO:0034605]; cellular response to virus [GO:0098586]; central nervous system neuron axonogenesis [GO:0021955]; chaperone-mediated autophagy [GO:0061684]; chaperone-mediated protein complex assembly [GO:0051131]; establishment of cell polarity [GO:0030010]; mitochondrial transport [GO:0006839]; neuron migration [GO:0001764]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of cell size [GO:0045793]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein polymerization [GO:0032273]; positive regulation of tau-protein kinase activity [GO:1902949]; positive regulation of telomerase activity [GO:0051973]; protein folding [GO:0006457]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; protein unfolding [GO:0043335]; regulation of apoptotic process [GO:0042981]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; regulation of protein-containing complex assembly [GO:0043254]; response to antibiotic [GO:0046677]; response to cocaine [GO:0042220]; response to cold [GO:0009409]; response to estrogen [GO:0043627]; response to heat [GO:0009408]; response to salt stress [GO:0009651]; response to unfolded protein [GO:0006986]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle contraction [GO:0003009]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance via telomerase [GO:0007004]	apical plasma membrane [GO:0016324]; axonal growth cone [GO:0044295]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; sperm mitochondrial sheath [GO:0097226]; sperm plasma membrane [GO:0097524]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; CTP binding [GO:0002135]; dATP binding [GO:0032564]; disordered domain specific binding [GO:0097718]; DNA polymerase binding [GO:0070182]; GTP binding [GO:0005525]; GTPase binding [GO:0051020]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; MHC class II protein complex binding [GO:0023026]; mRNA binding [GO:0003729]; nitric-oxide synthase regulator activity [GO:0030235]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; Rho GDP-dissociation inhibitor binding [GO:0051022]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; sulfonylurea receptor binding [GO:0017098]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; UTP binding [GO:0002134]	apical plasma membrane [GO:0016324]; axonal growth cone [GO:0044295]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; sperm mitochondrial sheath [GO:0097226]; sperm plasma membrane [GO:0097524]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; CTP binding [GO:0002135]; dATP binding [GO:0032564]; disordered domain specific binding [GO:0097718]; DNA polymerase binding [GO:0070182]; GTP binding [GO:0005525]; GTPase binding [GO:0051020]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; MHC class II protein complex binding [GO:0023026]; mRNA binding [GO:0003729]; nitric-oxide synthase regulator activity [GO:0030235]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; Rho GDP-dissociation inhibitor binding [GO:0051022]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; sulfonylurea receptor binding [GO:0017098]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; UTP binding [GO:0002134]; activation of innate immune response [GO:0002218]; axon extension [GO:0048675]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to heat [GO:0034605]; cellular response to virus [GO:0098586]; central nervous system neuron axonogenesis [GO:0021955]; chaperone-mediated autophagy [GO:0061684]; chaperone-mediated protein complex assembly [GO:0051131]; establishment of cell polarity [GO:0030010]; mitochondrial transport [GO:0006839]; neuron migration [GO:0001764]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of cell size [GO:0045793]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein polymerization [GO:0032273]; positive regulation of tau-protein kinase activity [GO:1902949]; positive regulation of telomerase activity [GO:0051973]; protein folding [GO:0006457]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; protein unfolding [GO:0043335]; regulation of apoptotic process [GO:0042981]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; regulation of protein-containing complex assembly [GO:0043254]; response to antibiotic [GO:0046677]; response to cocaine [GO:0042220]; response to cold [GO:0009409]; response to estrogen [GO:0043627]; response to heat [GO:0009408]; response to salt stress [GO:0009651]; response to unfolded protein [GO:0006986]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle contraction [GO:0003009]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P07901}. Cytoplasm {ECO:0000250|UniProtKB:P07901}. Melanosome {ECO:0000269|PubMed:17081065}. Cell membrane {ECO:0000269|PubMed:11276205}. Mitochondrion {ECO:0000269|PubMed:25609812}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
P07902	reviewed	GALT_HUMAN	Galactose-1-phosphate uridylyltransferase (Gal-1-P uridylyltransferase) (EC 2.7.7.12) (UDP-glucose--hexose-1-phosphate uridylyltransferase)	GALT	Homo sapiens (Human)	379	FUNCTION: Plays an important role in galactose metabolism. {ECO:0000269|PubMed:22461411, ECO:0000269|PubMed:27005423}.		galactose catabolic process [GO:0019388]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012]; UDP-glucose metabolic process [GO:0006011]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]	UDP-glucose:hexose-1-phosphate uridylyltransferase activity [GO:0008108]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; UDP-glucose:hexose-1-phosphate uridylyltransferase activity [GO:0008108]; zinc ion binding [GO:0008270]; galactose catabolic process [GO:0019388]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012]; UDP-glucose metabolic process [GO:0006011]	
P07910	reviewed	HNRPC_HUMAN	Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)	HNRNPC HNRPC	Homo sapiens (Human)	306	FUNCTION: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}.		3'-UTR-mediated mRNA stabilization [GO:0070935]; chromatin remodeling [GO:0006338]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of telomere maintenance via telomerase [GO:0032211]; osteoblast differentiation [GO:0001649]; RNA splicing [GO:0008380]	actin cytoskeleton [GO:0015629]; catalytic step 2 spliceosome [GO:0071013]; chromatin [GO:0000785]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]	identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; N6-methyladenosine-containing RNA binding [GO:1990247]; nucleosomal DNA binding [GO:0031492]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	actin cytoskeleton [GO:0015629]; catalytic step 2 spliceosome [GO:0071013]; chromatin [GO:0000785]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]; identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; N6-methyladenosine-containing RNA binding [GO:1990247]; nucleosomal DNA binding [GO:0031492]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; chromatin remodeling [GO:0006338]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of telomere maintenance via telomerase [GO:0032211]; osteoblast differentiation [GO:0001649]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus. Note=Component of ribonucleosomes.
P07911	reviewed	UROM_HUMAN	Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]	UMOD	Homo sapiens (Human)	640	FUNCTION: [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515). {ECO:0000269|PubMed:20798515, ECO:0000269|PubMed:3498215, ECO:0000305}.; FUNCTION: [Uromodulin, secreted form]: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals (By similarity). Protects against urinary tract infections by binding to type 1 fimbriated E.coli (PubMed:11134021, PubMed:32616672). Binds to bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E.coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation (PubMed:11134021, PubMed:32616672). Also promotes aggregation of other bacteria including K.pneumoniae, P.aeruginosa and S.mitis and so may also protect against other uropathogens (PubMed:32616672). {ECO:0000250|UniProtKB:Q91X17, ECO:0000269|PubMed:11134021, ECO:0000269|PubMed:32616672}.		antibacterial innate immune response [GO:0140367]; apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; cellular defense response [GO:0006968]; cellular response to unfolded protein [GO:0034620]; chaperone-mediated protein folding [GO:0061077]; citric acid secretion [GO:0046720]; collecting duct development [GO:0072044]; connective tissue replacement [GO:0097709]; defense response to Gram-negative bacterium [GO:0050829]; endoplasmic reticulum organization [GO:0007029]; glomerular filtration [GO:0003094]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; intracellular chloride ion homeostasis [GO:0030644]; intracellular phosphate ion homeostasis [GO:0030643]; intracellular sodium ion homeostasis [GO:0006883]; juxtaglomerular apparatus development [GO:0072051]; leukocyte cell-cell adhesion [GO:0007159]; lipid metabolic process [GO:0006629]; metanephric ascending thin limb development [GO:0072218]; metanephric distal convoluted tubule development [GO:0072221]; metanephric thick ascending limb development [GO:0072233]; micturition [GO:0060073]; multicellular organismal response to stress [GO:0033555]; negative regulation of cell population proliferation [GO:0008285]; neutrophil migration [GO:1990266]; organ or tissue specific immune response [GO:0002251]; potassium ion homeostasis [GO:0055075]; protein localization to vacuole [GO:0072665]; protein transport into plasma membrane raft [GO:0044861]; regulation of blood pressure [GO:0008217]; regulation of protein transport [GO:0051223]; regulation of urine volume [GO:0035809]; renal sodium ion absorption [GO:0070294]; renal urate salt excretion [GO:0097744]; renal water homeostasis [GO:0003091]; response to lipopolysaccharide [GO:0032496]; response to water deprivation [GO:0009414]; response to xenobiotic stimulus [GO:0009410]; RNA splicing [GO:0008380]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; ubiquitin-dependent ERAD pathway [GO:0030433]; urate transport [GO:0015747]; urea transmembrane transport [GO:0071918]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extrinsic component of membrane [GO:0019898]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; side of membrane [GO:0098552]; spindle pole [GO:0000922]	calcium ion binding [GO:0005509]; IgG binding [GO:0019864]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extrinsic component of membrane [GO:0019898]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; side of membrane [GO:0098552]; spindle pole [GO:0000922]; calcium ion binding [GO:0005509]; IgG binding [GO:0019864]; antibacterial innate immune response [GO:0140367]; apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; cellular defense response [GO:0006968]; cellular response to unfolded protein [GO:0034620]; chaperone-mediated protein folding [GO:0061077]; citric acid secretion [GO:0046720]; collecting duct development [GO:0072044]; connective tissue replacement [GO:0097709]; defense response to Gram-negative bacterium [GO:0050829]; endoplasmic reticulum organization [GO:0007029]; glomerular filtration [GO:0003094]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; intracellular chloride ion homeostasis [GO:0030644]; intracellular phosphate ion homeostasis [GO:0030643]; intracellular sodium ion homeostasis [GO:0006883]; juxtaglomerular apparatus development [GO:0072051]; leukocyte cell-cell adhesion [GO:0007159]; lipid metabolic process [GO:0006629]; metanephric ascending thin limb development [GO:0072218]; metanephric distal convoluted tubule development [GO:0072221]; metanephric thick ascending limb development [GO:0072233]; micturition [GO:0060073]; multicellular organismal response to stress [GO:0033555]; negative regulation of cell population proliferation [GO:0008285]; neutrophil migration [GO:1990266]; organ or tissue specific immune response [GO:0002251]; potassium ion homeostasis [GO:0055075]; protein localization to vacuole [GO:0072665]; protein transport into plasma membrane raft [GO:0044861]; regulation of blood pressure [GO:0008217]; regulation of protein transport [GO:0051223]; regulation of urine volume [GO:0035809]; renal sodium ion absorption [GO:0070294]; renal urate salt excretion [GO:0097744]; renal water homeostasis [GO:0003091]; response to lipopolysaccharide [GO:0032496]; response to water deprivation [GO:0009414]; response to xenobiotic stimulus [GO:0009410]; RNA splicing [GO:0008380]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; ubiquitin-dependent ERAD pathway [GO:0030433]; urate transport [GO:0015747]; urea transmembrane transport [GO:0071918]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:22776760, ECO:0000269|PubMed:23988501, ECO:0000269|PubMed:26673890, ECO:0000269|PubMed:7028707}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2249987}. Basolateral cell membrane {ECO:0000269|PubMed:7028707}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2249987}. Cell projection, cilium membrane {ECO:0000269|PubMed:20172860}. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization (PubMed:22776760). Secreted into urine after cleavage (PubMed:18375198, PubMed:26811476). Colocalizes with NPHP1 and KIF3A (PubMed:20172860). {ECO:0000269|PubMed:18375198, ECO:0000269|PubMed:20172860, ECO:0000269|PubMed:26811476, ECO:0000269|PubMed:3453112, ECO:0000269|PubMed:7028707}.; SUBCELLULAR LOCATION: [Uromodulin, secreted form]: Secreted {ECO:0000269|PubMed:18375198, ECO:0000269|PubMed:19005207, ECO:0000269|PubMed:26673890, ECO:0000269|PubMed:26811476, ECO:0000269|PubMed:3453112, ECO:0000269|PubMed:7028707}. Note=Detected in urine. {ECO:0000269|PubMed:18375198, ECO:0000269|PubMed:26811476, ECO:0000269|PubMed:3453112, ECO:0000269|PubMed:7028707}.
P07919	reviewed	QCR6_HUMAN	Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein)	UQCRH	Homo sapiens (Human)	91	FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}.		aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]	mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]	ubiquinol-cytochrome-c reductase activity [GO:0008121]	mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00127}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00127}; Intermembrane side {ECO:0000250|UniProtKB:P00127}.
P07942	reviewed	LAMB1_HUMAN	Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta)	LAMB1	Homo sapiens (Human)	1786	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}.		cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; neuron projection development [GO:0031175]; neuronal-glial interaction involved in cerebral cortex radial glia guided migration [GO:0021812]; odontogenesis [GO:0042476]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; substrate adhesion-dependent cell spreading [GO:0034446]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-1 complex [GO:0005606]; laminin-10 complex [GO:0043259]; laminin-2 complex [GO:0005607]; laminin-8 complex [GO:0043257]; perinuclear region of cytoplasm [GO:0048471]; protein complex involved in cell-matrix adhesion [GO:0098637]	extracellular matrix structural constituent [GO:0005201]; structural molecule activity [GO:0005198]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-1 complex [GO:0005606]; laminin-10 complex [GO:0043259]; laminin-2 complex [GO:0005607]; laminin-8 complex [GO:0043257]; perinuclear region of cytoplasm [GO:0048471]; protein complex involved in cell-matrix adhesion [GO:0098637]; extracellular matrix structural constituent [GO:0005201]; structural molecule activity [GO:0005198]; cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; neuron projection development [GO:0031175]; neuronal-glial interaction involved in cerebral cortex radial glia guided migration [GO:0021812]; odontogenesis [GO:0042476]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
P07947	reviewed	YES_HUMAN	Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)	YES1 YES	Homo sapiens (Human)	543	FUNCTION: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}.		cell differentiation [GO:0030154]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; leukocyte migration [GO:0050900]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; phosphorylation [GO:0016310]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein modification process [GO:0036211]; regulation of glucose transmembrane transport [GO:0010827]; regulation of vascular permeability [GO:0043114]; T cell costimulation [GO:0031295]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	actin filament [GO:0005884]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]	actin filament [GO:0005884]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; cell differentiation [GO:0030154]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; leukocyte migration [GO:0050900]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; phosphorylation [GO:0016310]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein modification process [GO:0036211]; regulation of glucose transmembrane transport [GO:0010827]; regulation of vascular permeability [GO:0043114]; T cell costimulation [GO:0031295]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.
P07948	reviewed	LYN_HUMAN	Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)	LYN JTK8	Homo sapiens (Human)	512	FUNCTION: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}.		adaptive immune response [GO:0002250]; B cell homeostasis [GO:0001782]; B cell receptor signaling pathway [GO:0050853]; C-X-C chemokine receptor CXCR4 signaling pathway [GO:0038159]; cellular response to extracellular stimulus [GO:0031668]; cellular response to heat [GO:0034605]; cellular response to retinoic acid [GO:0071300]; dendritic cell differentiation [GO:0097028]; DNA damage response [GO:0006974]; eosinophil differentiation [GO:0030222]; ephrin receptor signaling pathway [GO:0048013]; erythrocyte differentiation [GO:0030218]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; Fc receptor mediated stimulatory signaling pathway [GO:0002431]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; hematopoietic progenitor cell differentiation [GO:0002244]; histamine secretion by mast cell [GO:0002553]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; innate immune response [GO:0045087]; interleukin-5-mediated signaling pathway [GO:0038043]; intracellular signal transduction [GO:0035556]; leukocyte migration [GO:0050900]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of immune response [GO:0050777]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of intracellular signal transduction [GO:1902532]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of mast cell proliferation [GO:0070667]; negative regulation of myeloid leukocyte differentiation [GO:0002762]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; neuron projection development [GO:0031175]; oligodendrocyte development [GO:0014003]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet degranulation [GO:0002576]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060369]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of neuron projection development [GO:0010976]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress-activated protein kinase signaling cascade [GO:0070304]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of B cell apoptotic process [GO:0002902]; regulation of B cell receptor signaling pathway [GO:0050855]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cytokine production [GO:0001817]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of erythrocyte differentiation [GO:0045646]; regulation of mast cell activation [GO:0033003]; regulation of mast cell degranulation [GO:0043304]; regulation of monocyte chemotaxis [GO:0090025]; regulation of platelet aggregation [GO:0090330]; regulation of protein phosphorylation [GO:0001932]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; response to amino acid [GO:0043200]; response to axon injury [GO:0048678]; response to carbohydrate [GO:0009743]; response to hormone [GO:0009725]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070]; response to sterol depletion [GO:0006991]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell costimulation [GO:0031295]; tolerance induction to self antigen [GO:0002513]; toll-like receptor 4 signaling pathway [GO:0034142]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; integrin alpha2-beta1 complex [GO:0034666]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane raft [GO:0045121]; mitochondrial crista [GO:0030061]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic specialization, intracellular component [GO:0099091]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; gamma-tubulin binding [GO:0043015]; glycosphingolipid binding [GO:0043208]; integrin binding [GO:0005178]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphoprotein binding [GO:0051219]; phosphorylation-dependent protein binding [GO:0140031]; platelet-derived growth factor receptor binding [GO:0005161]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]	adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; integrin alpha2-beta1 complex [GO:0034666]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane raft [GO:0045121]; mitochondrial crista [GO:0030061]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic specialization, intracellular component [GO:0099091]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; gamma-tubulin binding [GO:0043015]; glycosphingolipid binding [GO:0043208]; integrin binding [GO:0005178]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphoprotein binding [GO:0051219]; phosphorylation-dependent protein binding [GO:0140031]; platelet-derived growth factor receptor binding [GO:0005161]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; adaptive immune response [GO:0002250]; B cell homeostasis [GO:0001782]; B cell receptor signaling pathway [GO:0050853]; C-X-C chemokine receptor CXCR4 signaling pathway [GO:0038159]; cellular response to extracellular stimulus [GO:0031668]; cellular response to heat [GO:0034605]; cellular response to retinoic acid [GO:0071300]; dendritic cell differentiation [GO:0097028]; DNA damage response [GO:0006974]; eosinophil differentiation [GO:0030222]; ephrin receptor signaling pathway [GO:0048013]; erythrocyte differentiation [GO:0030218]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; Fc receptor mediated stimulatory signaling pathway [GO:0002431]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; hematopoietic progenitor cell differentiation [GO:0002244]; histamine secretion by mast cell [GO:0002553]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; innate immune response [GO:0045087]; interleukin-5-mediated signaling pathway [GO:0038043]; intracellular signal transduction [GO:0035556]; leukocyte migration [GO:0050900]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of immune response [GO:0050777]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of intracellular signal transduction [GO:1902532]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of mast cell proliferation [GO:0070667]; negative regulation of myeloid leukocyte differentiation [GO:0002762]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; neuron projection development [GO:0031175]; oligodendrocyte development [GO:0014003]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet degranulation [GO:0002576]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060369]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of neuron projection development [GO:0010976]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress-activated protein kinase signaling cascade [GO:0070304]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of B cell apoptotic process [GO:0002902]; regulation of B cell receptor signaling pathway [GO:0050855]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cytokine production [GO:0001817]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of erythrocyte differentiation [GO:0045646]; regulation of mast cell activation [GO:0033003]; regulation of mast cell degranulation [GO:0043304]; regulation of monocyte chemotaxis [GO:0090025]; regulation of platelet aggregation [GO:0090330]; regulation of protein phosphorylation [GO:0001932]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; response to amino acid [GO:0043200]; response to axon injury [GO:0048678]; response to carbohydrate [GO:0009743]; response to hormone [GO:0009725]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070]; response to sterol depletion [GO:0006991]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell costimulation [GO:0031295]; tolerance induction to self antigen [GO:0002513]; toll-like receptor 4 signaling pathway [GO:0034142]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts.
P07949	reviewed	RET_HUMAN	Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]	RET CDHF12 CDHR16 PTC RET51	Homo sapiens (Human)	1114	FUNCTION: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration. Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways (PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL (PubMed:28846099). {ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886}.	MISCELLANEOUS: Treatment with withaferin A (WA) leads tumor regression in medullary thyroid carcinomas (MTC).	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; axon guidance [GO:0007411]; cellular response to retinoic acid [GO:0071300]; embryonic epithelial tube formation [GO:0001838]; enteric nervous system development [GO:0048484]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; innervation [GO:0060384]; lymphocyte migration into lymphoid organs [GO:0097021]; MAPK cascade [GO:0000165]; membrane protein proteolysis [GO:0033619]; neural crest cell migration [GO:0001755]; neuron cell-cell adhesion [GO:0007158]; neuron maturation [GO:0042551]; Peyer's patch morphogenesis [GO:0061146]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration [GO:0030335]; positive regulation of cell size [GO:0045793]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of neuron maturation [GO:0014042]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; posterior midgut development [GO:0007497]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of cell adhesion [GO:0030155]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; ureter maturation [GO:0035799]; ureteric bud development [GO:0001657]	axon [GO:0030424]; dendrite [GO:0030425]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; protein tyrosine kinase activity [GO:0004713]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	axon [GO:0030424]; dendrite [GO:0030425]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; protein tyrosine kinase activity [GO:0004713]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; axon guidance [GO:0007411]; cellular response to retinoic acid [GO:0071300]; embryonic epithelial tube formation [GO:0001838]; enteric nervous system development [GO:0048484]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; innervation [GO:0060384]; lymphocyte migration into lymphoid organs [GO:0097021]; MAPK cascade [GO:0000165]; membrane protein proteolysis [GO:0033619]; neural crest cell migration [GO:0001755]; neuron cell-cell adhesion [GO:0007158]; neuron maturation [GO:0042551]; Peyer's patch morphogenesis [GO:0061146]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration [GO:0030335]; positive regulation of cell size [GO:0045793]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of neuron maturation [GO:0014042]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; posterior midgut development [GO:0007497]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of cell adhesion [GO:0030155]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; ureter maturation [GO:0035799]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19823924, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:28953886}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}. Endosome membrane {ECO:0000269|PubMed:19823924, ECO:0000269|PubMed:23333276}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}. Note=Predominantly located on the plasma membrane. In the presence of SORL1 and GFRA1, directed to endosomes. {ECO:0000269|PubMed:23333276}.
P07951	reviewed	TPM2_HUMAN	Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)	TPM2 TMSB	Homo sapiens (Human)	284	FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}.		actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; regulation of ATP-dependent activity [GO:0043462]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytosol [GO:0005829]; muscle thin filament tropomyosin [GO:0005862]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytosol [GO:0005829]; muscle thin filament tropomyosin [GO:0005862]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307]; actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; regulation of ATP-dependent activity [GO:0043462]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P58775}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P58775}.
P07954	reviewed	FUMH_HUMAN	Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2)	FH	Homo sapiens (Human)	510	FUNCTION: Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:30761759). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). {ECO:0000269|PubMed:30761759, ECO:0000305}.; FUNCTION: [Isoform Mitochondrial]: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. {ECO:0000250|UniProtKB:P10173}.; FUNCTION: [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate (By similarity). Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (PubMed:20231875, PubMed:26237645). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (PubMed:26237645). {ECO:0000250|UniProtKB:P97807, ECO:0000269|PubMed:20231875, ECO:0000269|PubMed:26237645}.	MISCELLANEOUS: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. {ECO:0000250|UniProtKB:P05042, ECO:0000250|UniProtKB:P9WN93}.	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; fumarate metabolic process [GO:0006106]; homeostasis of number of cells within a tissue [GO:0048873]; malate metabolic process [GO:0006108]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; regulation of arginine metabolic process [GO:0000821]; tricarboxylic acid cycle [GO:0006099]; urea cycle [GO:0000050]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; tricarboxylic acid cycle enzyme complex [GO:0045239]	fumarate hydratase activity [GO:0004333]; histone binding [GO:0042393]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; tricarboxylic acid cycle enzyme complex [GO:0045239]; fumarate hydratase activity [GO:0004333]; histone binding [GO:0042393]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; fumarate metabolic process [GO:0006106]; homeostasis of number of cells within a tissue [GO:0048873]; malate metabolic process [GO:0006108]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; regulation of arginine metabolic process [GO:0000821]; tricarboxylic acid cycle [GO:0006099]; urea cycle [GO:0000050]	SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion {ECO:0000269|PubMed:27037871}.; SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm, cytosol {ECO:0000269|PubMed:20231875, ECO:0000269|PubMed:22509282, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:27037871}. Nucleus {ECO:0000269|PubMed:20231875, ECO:0000269|PubMed:26237645}. Chromosome {ECO:0000269|PubMed:26237645}. Note=Translocates to the nucleus in response to DNA damage: localizes to DNA double-strand breaks (DSBs) following phosphorylation by PRKDC. {ECO:0000269|PubMed:26237645}.
P07988	reviewed	PSPB_HUMAN	Pulmonary surfactant-associated protein B (SP-B) (18 kDa pulmonary-surfactant protein) (6 kDa protein) (Pulmonary surfactant-associated proteolipid SPL(Phe))	SFTPB SFTP3	Homo sapiens (Human)	381	FUNCTION: Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).	animal organ morphogenesis [GO:0009887]; respiratory gaseous exchange by respiratory system [GO:0007585]; sphingolipid metabolic process [GO:0006665]	alveolar lamellar body [GO:0097208]; clathrin-coated endocytic vesicle [GO:0045334]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; multivesicular body lumen [GO:0097486]		alveolar lamellar body [GO:0097208]; clathrin-coated endocytic vesicle [GO:0045334]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; multivesicular body lumen [GO:0097486]; animal organ morphogenesis [GO:0009887]; respiratory gaseous exchange by respiratory system [GO:0007585]; sphingolipid metabolic process [GO:0006665]	SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
P07992	reviewed	ERCC1_HUMAN	DNA excision repair protein ERCC-1	ERCC1	Homo sapiens (Human)	297	FUNCTION: [Isoform 1]: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. {ECO:0000269|PubMed:17273966, ECO:0000269|PubMed:23623389, ECO:0000269|PubMed:24036546}.; FUNCTION: [Isoform 2]: Not functional in the nucleotide excision repair pathway. {ECO:0000305|PubMed:24036546}.; FUNCTION: [Isoform 3]: Not functional in the nucleotide excision repair pathway. {ECO:0000305|PubMed:24036546}.; FUNCTION: [Isoform 4]: Not functional in the nucleotide excision repair pathway. {ECO:0000305|PubMed:24036546}.		cell population proliferation [GO:0008283]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; double-strand break repair via nonhomologous end joining [GO:0006303]; embryonic organ development [GO:0048568]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; male gonad development [GO:0008584]; mitotic recombination [GO:0006312]; multicellular organism growth [GO:0035264]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of telomere maintenance [GO:0032205]; nucleotide-excision repair [GO:0006289]; oogenesis [GO:0048477]; positive regulation of t-circle formation [GO:1904431]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; post-embryonic hemopoiesis [GO:0035166]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; replicative senescence [GO:0090399]; response to cadmium ion [GO:0046686]; response to immobilization stress [GO:0035902]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to sucrose [GO:0009744]; response to X-ray [GO:0010165]; spermatogenesis [GO:0007283]; syncytium formation [GO:0006949]; t-circle formation [GO:0090656]; telomeric DNA-containing double minutes formation [GO:0061819]; UV protection [GO:0009650]; UV-damage excision repair [GO:0070914]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; ERCC4-ERCC1 complex [GO:0070522]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 1 complex [GO:0000110]	damaged DNA binding [GO:0003684]; promoter-specific chromatin binding [GO:1990841]; single-stranded DNA binding [GO:0003697]; TFIID-class transcription factor complex binding [GO:0001094]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; ERCC4-ERCC1 complex [GO:0070522]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 1 complex [GO:0000110]; damaged DNA binding [GO:0003684]; promoter-specific chromatin binding [GO:1990841]; single-stranded DNA binding [GO:0003697]; TFIID-class transcription factor complex binding [GO:0001094]; cell population proliferation [GO:0008283]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; double-strand break repair via nonhomologous end joining [GO:0006303]; embryonic organ development [GO:0048568]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; male gonad development [GO:0008584]; mitotic recombination [GO:0006312]; multicellular organism growth [GO:0035264]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of telomere maintenance [GO:0032205]; nucleotide-excision repair [GO:0006289]; oogenesis [GO:0048477]; positive regulation of t-circle formation [GO:1904431]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; post-embryonic hemopoiesis [GO:0035166]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; replicative senescence [GO:0090399]; response to cadmium ion [GO:0046686]; response to immobilization stress [GO:0035902]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to sucrose [GO:0009744]; response to X-ray [GO:0010165]; spermatogenesis [GO:0007283]; syncytium formation [GO:0006949]; t-circle formation [GO:0090656]; telomeric DNA-containing double minutes formation [GO:0061819]; UV protection [GO:0009650]; UV-damage excision repair [GO:0070914]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:24036546}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:24036546}. Nucleus {ECO:0000269|PubMed:24036546}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:24036546}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000269|PubMed:24036546}.
P07996	reviewed	TSP1_HUMAN	Thrombospondin-1 (Glycoprotein G)	THBS1 TSP TSP1	Homo sapiens (Human)	1170	FUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions (PubMed:2430973, PubMed:6489349, PubMed:15014436, PubMed:18285447). Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis (PubMed:14568985, PubMed:1371676, PubMed:10613822, PubMed:11134179, PubMed:24511121, PubMed:29042481, PubMed:32679764). Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis (PubMed:14568985). Ligand for receptor CD47 (PubMed:8550562, PubMed:19004835). Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS (PubMed:29042481). Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). Negatively modulates wound healing, acting via CD47 (By similarity). Ligand for receptor CD36 (PubMed:1371676, PubMed:10613822, PubMed:11134179). Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36 (By similarity). Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47 (PubMed:1371676, PubMed:10613822, PubMed:32679764, PubMed:11134179). Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner (PubMed:29042481). Ligand for immunoglobulin-like cell surface receptor SIRPA (PubMed:24511121). Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA (PubMed:24511121). Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity; its effects may be mediated, at least in part, through enhanced adipocyte proliferation (By similarity). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). May be involved in age-related conditions, including metabolic dysregulation, during normal aging (PubMed:29042481, PubMed:32679764). {ECO:0000250|UniProtKB:P35441, ECO:0000269|PubMed:10613822, ECO:0000269|PubMed:11134179, ECO:0000269|PubMed:1371676, ECO:0000269|PubMed:14568985, ECO:0000269|PubMed:15014436, ECO:0000269|PubMed:18285447, ECO:0000269|PubMed:19004835, ECO:0000269|PubMed:2430973, ECO:0000269|PubMed:24511121, ECO:0000269|PubMed:29042481, ECO:0000269|PubMed:32679764, ECO:0000269|PubMed:6489349, ECO:0000269|PubMed:8550562}.		apoptotic process [GO:0006915]; behavioral response to pain [GO:0048266]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heat [GO:0034605]; cellular response to tumor necrosis factor [GO:0071356]; chronic inflammatory response [GO:0002544]; engulfment of apoptotic cell [GO:0043652]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002581]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of nitric oxide mediated signal transduction [GO:0010751]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of sprouting angiogenesis [GO:1903671]; peptide cross-linking [GO:0018149]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of transforming growth factor beta1 production [GO:0032914]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor production [GO:0032760]; response to calcium ion [GO:0051592]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to magnesium ion [GO:0032026]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to unfolded protein [GO:0006986]; response to xenobiotic stimulus [GO:0009410]; sprouting angiogenesis [GO:0002040]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; sarcoplasmic reticulum [GO:0016529]; secretory granule [GO:0030141]	calcium ion binding [GO:0005509]; collagen V binding [GO:0070052]; endopeptidase inhibitor activity [GO:0004866]; extracellular matrix structural constituent [GO:0005201]; fibrinogen binding [GO:0070051]; fibroblast growth factor binding [GO:0017134]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; low-density lipoprotein particle binding [GO:0030169]; phosphatidylserine binding [GO:0001786]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; transforming growth factor beta binding [GO:0050431]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; sarcoplasmic reticulum [GO:0016529]; secretory granule [GO:0030141]; calcium ion binding [GO:0005509]; collagen V binding [GO:0070052]; endopeptidase inhibitor activity [GO:0004866]; extracellular matrix structural constituent [GO:0005201]; fibrinogen binding [GO:0070051]; fibroblast growth factor binding [GO:0017134]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; low-density lipoprotein particle binding [GO:0030169]; phosphatidylserine binding [GO:0001786]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; transforming growth factor beta binding [GO:0050431]; apoptotic process [GO:0006915]; behavioral response to pain [GO:0048266]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heat [GO:0034605]; cellular response to tumor necrosis factor [GO:0071356]; chronic inflammatory response [GO:0002544]; engulfment of apoptotic cell [GO:0043652]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002581]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of nitric oxide mediated signal transduction [GO:0010751]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of sprouting angiogenesis [GO:1903671]; peptide cross-linking [GO:0018149]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of transforming growth factor beta1 production [GO:0032914]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor production [GO:0032760]; response to calcium ion [GO:0051592]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to magnesium ion [GO:0032026]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to unfolded protein [GO:0006986]; response to xenobiotic stimulus [GO:0009410]; sprouting angiogenesis [GO:0002040]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:101549, ECO:0000269|PubMed:14568985, ECO:0000269|PubMed:6777381}. Cell surface {ECO:0000269|PubMed:6777381}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18285447, ECO:0000269|PubMed:6341993}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P35441}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:P35441}. Note=Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381, PubMed:101549). Incorporated into the extracellular matrix (ECM) of fibroblasts (PubMed:6341993). The C-terminal region in trimeric form is required for retention in the ECM (PubMed:18285447). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity). {ECO:0000250|UniProtKB:P35441, ECO:0000269|PubMed:6341993, ECO:0000269|PubMed:6777381}.
P07998	reviewed	RNAS1_HUMAN	Ribonuclease pancreatic (EC 4.6.1.18) (HP-RNase) (RIB-1) (RNase UpI-1) (Ribonuclease 1) (RNase 1) (Ribonuclease A) (RNase A)	RNASE1 RIB1 RNS1	Homo sapiens (Human)	156	FUNCTION: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA. {ECO:0000269|PubMed:17350650}.		defense response to Gram-positive bacterium [GO:0050830]	extracellular exosome [GO:0070062]	lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540]	extracellular exosome [GO:0070062]; lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540]; defense response to Gram-positive bacterium [GO:0050830]	SUBCELLULAR LOCATION: Secreted.
P08034	reviewed	CXB1_HUMAN	Gap junction beta-1 protein (Connexin-32) (Cx32) (GAP junction 28 kDa liver protein)	GJB1 CX32	Homo sapiens (Human)	283	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.		cell-cell signaling [GO:0007267]; epididymis development [GO:1905867]; gap junction assembly [GO:0016264]; nervous system development [GO:0007399]; purine ribonucleotide transport [GO:0015868]	connexin complex [GO:0005922]; endoplasmic reticulum membrane [GO:0005789]; lateral plasma membrane [GO:0016328]	gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802]	connexin complex [GO:0005922]; endoplasmic reticulum membrane [GO:0005789]; lateral plasma membrane [GO:0016328]; gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802]; cell-cell signaling [GO:0007267]; epididymis development [GO:1905867]; gap junction assembly [GO:0016264]; nervous system development [GO:0007399]; purine ribonucleotide transport [GO:0015868]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
P08047	reviewed	SP1_HUMAN	Transcription factor Sp1	SP1 TSFP1	Homo sapiens (Human)	785	FUNCTION: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247, PubMed:21046154). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}.	MISCELLANEOUS: In the hepatoma cell line Hep-G2, SP1 precursor mRNA may undergo homotype trans-splicing leading to the duplication of exons 2 and 3.	cellular response to estrogen stimulus [GO:0071391]; cellular response to insulin stimulus [GO:0032869]; cellular response to wortmannin [GO:1904568]; cellular response to zinc ion starvation [GO:0034224]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of hydrogen sulfide biosynthetic process [GO:1904828]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hydroperoxide [GO:0033194]; rhythmic process [GO:0048511]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription repressor complex [GO:0017053]	bHLH transcription factor binding [GO:0043425]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription repressor complex [GO:0017053]; bHLH transcription factor binding [GO:0043425]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; cellular response to estrogen stimulus [GO:0071391]; cellular response to insulin stimulus [GO:0032869]; cellular response to wortmannin [GO:1904568]; cellular response to zinc ion starvation [GO:0034224]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of hydrogen sulfide biosynthetic process [GO:1904828]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hydroperoxide [GO:0033194]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.
P08048	reviewed	ZFY_HUMAN	Zinc finger Y-chromosomal protein	ZFY	Homo sapiens (Human)	801	FUNCTION: Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'. {ECO:0000269|PubMed:20028140}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P08069	reviewed	IGF1R_HUMAN	Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]	IGF1R	Homo sapiens (Human)	1367	FUNCTION: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.		amyloid-beta clearance [GO:0097242]; axonogenesis [GO:0007409]; cardiac atrium development [GO:0003230]; cellular response to aldosterone [GO:1904045]; cellular response to amyloid-beta [GO:1904646]; cellular response to angiotensin [GO:1904385]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to mechanical stimulus [GO:0071260]; cellular response to progesterone stimulus [GO:0071393]; cellular response to testosterone stimulus [GO:0071394]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to zinc ion starvation [GO:0034224]; cellular senescence [GO:0090398]; cerebellum development [GO:0021549]; dendritic spine maintenance [GO:0097062]; establishment of cell polarity [GO:0030010]; estrous cycle [GO:0044849]; hippocampus development [GO:0021766]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cholangiocyte apoptotic process [GO:1904193]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of muscle cell apoptotic process [GO:0010656]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytokinesis [GO:0032467]; positive regulation of DNA metabolic process [GO:0051054]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of steroid hormone biosynthetic process [GO:0090031]; protein autophosphorylation [GO:0046777]; regulation of JNK cascade [GO:0046328]; response to alkaloid [GO:0043279]; response to ethanol [GO:0045471]; response to L-glutamate [GO:1902065]; response to nicotine [GO:0035094]; response to vitamin E [GO:0033197]; signal transduction [GO:0007165]; transcytosis [GO:0045056]	alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; axon [GO:0030424]; caveola [GO:0005901]; insulin receptor complex [GO:0005899]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; protein kinase complex [GO:1902911]; receptor complex [GO:0043235]; T-tubule [GO:0030315]	ATP binding [GO:0005524]; G-protein alpha-subunit binding [GO:0001965]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; insulin receptor activity [GO:0005009]; insulin receptor binding [GO:0005158]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor receptor activity [GO:0005010]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein transporter activity [GO:0140318]; protein tyrosine kinase activity [GO:0004713]	alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; axon [GO:0030424]; caveola [GO:0005901]; insulin receptor complex [GO:0005899]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; protein kinase complex [GO:1902911]; receptor complex [GO:0043235]; T-tubule [GO:0030315]; ATP binding [GO:0005524]; G-protein alpha-subunit binding [GO:0001965]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; insulin receptor activity [GO:0005009]; insulin receptor binding [GO:0005158]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor receptor activity [GO:0005010]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein transporter activity [GO:0140318]; protein tyrosine kinase activity [GO:0004713]; amyloid-beta clearance [GO:0097242]; axonogenesis [GO:0007409]; cardiac atrium development [GO:0003230]; cellular response to aldosterone [GO:1904045]; cellular response to amyloid-beta [GO:1904646]; cellular response to angiotensin [GO:1904385]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to mechanical stimulus [GO:0071260]; cellular response to progesterone stimulus [GO:0071393]; cellular response to testosterone stimulus [GO:0071394]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to zinc ion starvation [GO:0034224]; cellular senescence [GO:0090398]; cerebellum development [GO:0021549]; dendritic spine maintenance [GO:0097062]; establishment of cell polarity [GO:0030010]; estrous cycle [GO:0044849]; hippocampus development [GO:0021766]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cholangiocyte apoptotic process [GO:1904193]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of muscle cell apoptotic process [GO:0010656]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytokinesis [GO:0032467]; positive regulation of DNA metabolic process [GO:0051054]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of steroid hormone biosynthetic process [GO:0090031]; protein autophosphorylation [GO:0046777]; regulation of JNK cascade [GO:0046328]; response to alkaloid [GO:0043279]; response to ethanol [GO:0045471]; response to L-glutamate [GO:1902065]; response to nicotine [GO:0035094]; response to vitamin E [GO:0033197]; signal transduction [GO:0007165]; transcytosis [GO:0045056]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17524361}; Single-pass type I membrane protein {ECO:0000269|PubMed:17524361}.
P08100	reviewed	OPSD_HUMAN	Rhodopsin (Opsin-2)	RHO OPN2	Homo sapiens (Human)	348	FUNCTION: Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343). {ECO:0000269|PubMed:12566452, ECO:0000269|PubMed:2215617, ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425, ECO:0000269|PubMed:7846071, ECO:0000269|PubMed:8107847, ECO:0000305|PubMed:28524165}.		absorption of visible light [GO:0016038]; adaptation of rhodopsin mediated signaling [GO:0016062]; cellular response to light stimulus [GO:0071482]; detection of temperature stimulus involved in thermoception [GO:0050960]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; photoreceptor cell maintenance [GO:0045494]; phototransduction [GO:0007602]; phototransduction, visible light [GO:0007603]; rhodopsin mediated signaling pathway [GO:0016056]; rod bipolar cell differentiation [GO:1904389]; thermotaxis [GO:0043052]; visual perception [GO:0007601]	cell-cell junction [GO:0005911]; ciliary membrane [GO:0060170]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; membrane [GO:0016020]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; photoreceptor inner segment membrane [GO:0060342]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]; sperm head plasma membrane [GO:1990913]; sperm midpiece [GO:0097225]	11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]; metal ion binding [GO:0046872]	cell-cell junction [GO:0005911]; ciliary membrane [GO:0060170]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; membrane [GO:0016020]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; photoreceptor inner segment membrane [GO:0060342]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]; sperm head plasma membrane [GO:1990913]; sperm midpiece [GO:0097225]; 11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]; metal ion binding [GO:0046872]; absorption of visible light [GO:0016038]; adaptation of rhodopsin mediated signaling [GO:0016062]; cellular response to light stimulus [GO:0071482]; detection of temperature stimulus involved in thermoception [GO:0050960]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; photoreceptor cell maintenance [GO:0045494]; phototransduction [GO:0007602]; phototransduction, visible light [GO:0007603]; rhodopsin mediated signaling pathway [GO:0016056]; rod bipolar cell differentiation [GO:1904389]; thermotaxis [GO:0043052]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12566452, ECO:0000269|PubMed:19934218, ECO:0000269|PubMed:25664179, ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425}; Multi-pass membrane protein {ECO:0000269|PubMed:19934218, ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:25664179}. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia. {ECO:0000269|PubMed:25664179}.
P08118	reviewed	MSMB_HUMAN	Beta-microseminoprotein (Immunoglobulin-binding factor) (IGBF) (PN44) (Prostate secreted seminal plasma protein) (Prostate secretory protein of 94 amino acids) (PSP-94) (PSP94) (Seminal plasma beta-inhibin)	MSMB PRSP	Homo sapiens (Human)	114		MISCELLANEOUS: Specific receptors for this protein are found on spermatozoa and in the prostate.		extracellular space [GO:0005615]; nucleus [GO:0005634]		extracellular space [GO:0005615]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Secreted. Note=Sperm surface.
P08123	reviewed	CO1A2_HUMAN	Collagen alpha-2(I) chain (Alpha-2 type I collagen)	COL1A2	Homo sapiens (Human)	1366	FUNCTION: Type I collagen is a member of group I collagen (fibrillar forming collagen).		blood vessel development [GO:0001568]; bone mineralization [GO:0030282]; cellular response to amino acid stimulus [GO:0071230]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; extracellular matrix assembly [GO:0085029]; extracellular matrix organization [GO:0030198]; odontogenesis [GO:0042476]; protein heterotrimerization [GO:0070208]; regulation of blood pressure [GO:0008217]; Rho protein signal transduction [GO:0007266]; skeletal system development [GO:0001501]; skin morphogenesis [GO:0043589]; transforming growth factor beta receptor signaling pathway [GO:0007179]	collagen type I trimer [GO:0005584]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; protease binding [GO:0002020]; protein-macromolecule adaptor activity [GO:0030674]; SMAD binding [GO:0046332]	collagen type I trimer [GO:0005584]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; protease binding [GO:0002020]; protein-macromolecule adaptor activity [GO:0030674]; SMAD binding [GO:0046332]; blood vessel development [GO:0001568]; bone mineralization [GO:0030282]; cellular response to amino acid stimulus [GO:0071230]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; extracellular matrix assembly [GO:0085029]; extracellular matrix organization [GO:0030198]; odontogenesis [GO:0042476]; protein heterotrimerization [GO:0070208]; regulation of blood pressure [GO:0008217]; Rho protein signal transduction [GO:0007266]; skeletal system development [GO:0001501]; skin morphogenesis [GO:0043589]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
P08133	reviewed	ANXA6_HUMAN	Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70)	ANXA6 ANX6	Homo sapiens (Human)	673	FUNCTION: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.	MISCELLANEOUS: Seems to bind one calcium ion with high affinity.	apoptotic signaling pathway [GO:0097190]; growth plate cartilage chondrocyte differentiation [GO:0003418]; mitochondrial calcium ion homeostasis [GO:0051560]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of sequestering of calcium ion [GO:0051283]; neural crest cell migration [GO:0001755]; plasma membrane repair [GO:0001778]; regulation of muscle contraction [GO:0006937]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; sarcolemma [GO:0042383]	actin filament binding [GO:0051015]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; cholesterol binding [GO:0015485]; chondroitin sulfate binding [GO:0035374]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity [GO:0015276]; lipid binding [GO:0008289]; phosphatidylserine binding [GO:0001786]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; sarcolemma [GO:0042383]; actin filament binding [GO:0051015]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; cholesterol binding [GO:0015485]; chondroitin sulfate binding [GO:0035374]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity [GO:0015276]; lipid binding [GO:0008289]; phosphatidylserine binding [GO:0001786]; apoptotic signaling pathway [GO:0097190]; growth plate cartilage chondrocyte differentiation [GO:0003418]; mitochondrial calcium ion homeostasis [GO:0051560]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of sequestering of calcium ion [GO:0051283]; neural crest cell migration [GO:0001755]; plasma membrane repair [GO:0001778]; regulation of muscle contraction [GO:0006937]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
P08134	reviewed	RHOC_HUMAN	Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)	RHOC ARH9 ARHC	Homo sapiens (Human)	193	FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:20974804}.		actin filament organization [GO:0007015]; apical junction assembly [GO:0043297]; mitotic cytokinesis [GO:0000281]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of lipase activity [GO:0060193]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of stress fiber assembly [GO:0051496]; signal transduction [GO:0007165]; skeletal muscle satellite cell migration [GO:1902766]; small GTPase mediated signal transduction [GO:0007264]; wound healing, spreading of cells [GO:0044319]	cleavage furrow [GO:0032154]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]	cleavage furrow [GO:0032154]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin filament organization [GO:0007015]; apical junction assembly [GO:0043297]; mitotic cytokinesis [GO:0000281]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of lipase activity [GO:0060193]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of stress fiber assembly [GO:0051496]; signal transduction [GO:0007165]; skeletal muscle satellite cell migration [GO:1902766]; small GTPase mediated signal transduction [GO:0007264]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cleavage furrow {ECO:0000269|PubMed:16236794}. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
P08138	reviewed	TNR16_HUMAN	Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (p75 ICD) (CD antigen CD271)	NGFR TNFRSF16	Homo sapiens (Human)	427	FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). {ECO:0000250, ECO:0000250|UniProtKB:Q9Z0W1, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:3022937}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; axon guidance [GO:0007411]; cellular response to amyloid-beta [GO:1904646]; central nervous system development [GO:0007417]; circadian regulation of gene expression [GO:0032922]; detection of temperature stimulus [GO:0016048]; dorsal aorta development [GO:0035907]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast proliferation [GO:0048144]; glucose homeostasis [GO:0042593]; hair follicle morphogenesis [GO:0031069]; intracellular glucose homeostasis [GO:0001678]; intracellular protein transport [GO:0006886]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of hair follicle development [GO:0051799]; nerve development [GO:0021675]; neuron apoptotic process [GO:0051402]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of odontogenesis of dentin-containing tooth [GO:0042488]; positive regulation of protein localization to nucleus [GO:1900182]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; Rho protein signal transduction [GO:0007266]	cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endosome [GO:0005768]; extracellular region [GO:0005576]; growth cone [GO:0030426]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]	amyloid-beta binding [GO:0001540]; calmodulin binding [GO:0005516]; coreceptor activity [GO:0015026]; death receptor activity [GO:0005035]; nerve growth factor binding [GO:0048406]; neurotrophin binding [GO:0043121]; signaling receptor activity [GO:0038023]; small GTPase binding [GO:0031267]; transmembrane signaling receptor activity [GO:0004888]; ubiquitin protein ligase binding [GO:0031625]	cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endosome [GO:0005768]; extracellular region [GO:0005576]; growth cone [GO:0030426]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; amyloid-beta binding [GO:0001540]; calmodulin binding [GO:0005516]; coreceptor activity [GO:0015026]; death receptor activity [GO:0005035]; nerve growth factor binding [GO:0048406]; neurotrophin binding [GO:0043121]; signaling receptor activity [GO:0038023]; small GTPase binding [GO:0031267]; transmembrane signaling receptor activity [GO:0004888]; ubiquitin protein ligase binding [GO:0031625]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; axon guidance [GO:0007411]; cellular response to amyloid-beta [GO:1904646]; central nervous system development [GO:0007417]; circadian regulation of gene expression [GO:0032922]; detection of temperature stimulus [GO:0016048]; dorsal aorta development [GO:0035907]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast proliferation [GO:0048144]; glucose homeostasis [GO:0042593]; hair follicle morphogenesis [GO:0031069]; intracellular glucose homeostasis [GO:0001678]; intracellular protein transport [GO:0006886]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of hair follicle development [GO:0051799]; nerve development [GO:0021675]; neuron apoptotic process [GO:0051402]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of odontogenesis of dentin-containing tooth [GO:0042488]; positive regulation of protein localization to nucleus [GO:1900182]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:3022937}; Single-pass type I membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z0W1}.
P08151	reviewed	GLI1_HUMAN	Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)	GLI1 GLI	Homo sapiens (Human)	1106	FUNCTION: Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24076122, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.	MISCELLANEOUS: [Isoform 2]: Undetectable in normal cells but highly expressed in cancer cells. {ECO:0000305}.	cerebellar cortex morphogenesis [GO:0021696]; digestive tract morphogenesis [GO:0048546]; dorsal/ventral pattern formation [GO:0009953]; epidermal cell differentiation [GO:0009913]; liver regeneration [GO:0097421]; lung development [GO:0030324]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; notochord regression [GO:0060032]; osteoblast differentiation [GO:0001649]; pituitary gland development [GO:0021983]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; proximal/distal pattern formation [GO:0009954]; regulation of hepatocyte proliferation [GO:2000345]; regulation of osteoblast differentiation [GO:0045667]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]; response to wounding [GO:0009611]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [GO:0021938]; spermatid development [GO:0007286]; ventral midline development [GO:0007418]	axoneme [GO:0005930]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]	axoneme [GO:0005930]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; cerebellar cortex morphogenesis [GO:0021696]; digestive tract morphogenesis [GO:0048546]; dorsal/ventral pattern formation [GO:0009953]; epidermal cell differentiation [GO:0009913]; liver regeneration [GO:0097421]; lung development [GO:0030324]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; notochord regression [GO:0060032]; osteoblast differentiation [GO:0001649]; pituitary gland development [GO:0021983]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; proximal/distal pattern formation [GO:0009954]; regulation of hepatocyte proliferation [GO:2000345]; regulation of osteoblast differentiation [GO:0045667]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]; response to wounding [GO:0009611]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [GO:0021938]; spermatid development [GO:0007286]; ventral midline development [GO:0007418]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24076122}. Nucleus {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456}. Note=Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19878745}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19706761}. Nucleus {ECO:0000269|PubMed:19706761}.
P08172	reviewed	ACM2_HUMAN	Muscarinic acetylcholine receptor M2	CHRM2	Homo sapiens (Human)	466	FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}.		adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; chemical synaptic transmission [GO:0007268]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; nervous system development [GO:0007399]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of heart contraction [GO:0008016]; regulation of smooth muscle contraction [GO:0006940]; response to virus [GO:0009615]	asymmetric synapse [GO:0032279]; axon terminus [GO:0043679]; cholinergic synapse [GO:0098981]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; symmetric synapse [GO:0032280]; synapse [GO:0045202]	arrestin family protein binding [GO:1990763]; G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]	asymmetric synapse [GO:0032279]; axon terminus [GO:0043679]; cholinergic synapse [GO:0098981]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; symmetric synapse [GO:0032280]; synapse [GO:0045202]; arrestin family protein binding [GO:1990763]; G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; chemical synaptic transmission [GO:0007268]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; nervous system development [GO:0007399]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of heart contraction [GO:0008016]; regulation of smooth muscle contraction [GO:0006940]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}; Multi-pass membrane protein {ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:24256733}. Postsynaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250|UniProtKB:P06199}.
P08173	reviewed	ACM4_HUMAN	Muscarinic acetylcholine receptor M4	CHRM4	Homo sapiens (Human)	479	FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.		adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; cell surface receptor signaling pathway [GO:0007166]; chemical synaptic transmission [GO:0007268]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; regulation of locomotion [GO:0040012]; signal transduction [GO:0007165]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; cell surface receptor signaling pathway [GO:0007166]; chemical synaptic transmission [GO:0007268]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; regulation of locomotion [GO:0040012]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
P08174	reviewed	DAF_HUMAN	Complement decay-accelerating factor (CD antigen CD55)	CD55 CR DAF	Homo sapiens (Human)	381	FUNCTION: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}.	MISCELLANEOUS: [Isoform 6]: Includes partial sequence of the intron 7. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Includes full sequence of the intron 7. {ECO:0000305}.	complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation [GO:0045916]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of T cell cytokine production [GO:0002726]; regulation of complement activation [GO:0030449]; regulation of complement-dependent cytotoxicity [GO:1903659]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; respiratory burst [GO:0045730]	cell surface [GO:0009986]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; side of membrane [GO:0098552]; transport vesicle [GO:0030133]	lipid binding [GO:0008289]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; side of membrane [GO:0098552]; transport vesicle [GO:0030133]; lipid binding [GO:0008289]; virus receptor activity [GO:0001618]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation [GO:0045916]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of T cell cytokine production [GO:0002726]; regulation of complement activation [GO:0030449]; regulation of complement-dependent cytotoxicity [GO:1903659]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; respiratory burst [GO:0045730]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:16503113}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000269|PubMed:16503113}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000269|PubMed:16503113}.; SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane {ECO:0000305|PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:16503113}.; SUBCELLULAR LOCATION: [Isoform 7]: Cell membrane {ECO:0000305|PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:16503113}.
P08183	reviewed	MDR1_HUMAN	ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243)	ABCB1 MDR1 PGY1	Homo sapiens (Human)	1280	FUNCTION: Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218, PubMed:35970996). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218, PubMed:35970996). {ECO:0000269|PubMed:2897240, ECO:0000269|PubMed:35970996, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9038218}.		carboxylic acid transmembrane transport [GO:1905039]; ceramide translocation [GO:0099040]; export across plasma membrane [GO:0140115]; G2/M transition of mitotic cell cycle [GO:0000086]; phospholipid translocation [GO:0045332]; positive regulation of anion channel activity [GO:1901529]; regulation of chloride transport [GO:2001225]; regulation of response to osmotic stress [GO:0047484]; response to xenobiotic stimulus [GO:0009410]; stem cell proliferation [GO:0072089]; terpenoid transport [GO:0046865]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport across blood-brain barrier [GO:1990962]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carboxylic acid transmembrane transporter activity [GO:0046943]; ceramide floppase activity [GO:0099038]; efflux transmembrane transporter activity [GO:0015562]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylethanolamine flippase activity [GO:0090555]; transmembrane transporter activity [GO:0022857]; ubiquitin protein ligase binding [GO:0031625]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carboxylic acid transmembrane transporter activity [GO:0046943]; ceramide floppase activity [GO:0099038]; efflux transmembrane transporter activity [GO:0015562]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylethanolamine flippase activity [GO:0090555]; transmembrane transporter activity [GO:0022857]; ubiquitin protein ligase binding [GO:0031625]; xenobiotic transmembrane transporter activity [GO:0042910]; carboxylic acid transmembrane transport [GO:1905039]; ceramide translocation [GO:0099040]; export across plasma membrane [GO:0140115]; G2/M transition of mitotic cell cycle [GO:0000086]; phospholipid translocation [GO:0045332]; positive regulation of anion channel activity [GO:1901529]; regulation of chloride transport [GO:2001225]; regulation of response to osmotic stress [GO:0047484]; response to xenobiotic stimulus [GO:0009410]; stem cell proliferation [GO:0072089]; terpenoid transport [GO:0046865]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport across blood-brain barrier [GO:1990962]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:35970996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:8898203}. Cytoplasm {ECO:0000269|PubMed:35970996}. Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). Localized to the apical membrane of enterocytes (PubMed:28408210). {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:35970996}.
P08185	reviewed	CBG_HUMAN	Corticosteroid-binding globulin (CBG) (Serpin A6) (Transcortin)	SERPINA6 CBG	Homo sapiens (Human)	405	FUNCTION: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. {ECO:0000269|PubMed:18513745}.		glucocorticoid metabolic process [GO:0008211]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]; steroid binding [GO:0005496]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; steroid binding [GO:0005496]; glucocorticoid metabolic process [GO:0008211]	SUBCELLULAR LOCATION: Secreted.
P08195	reviewed	4F2_HUMAN	Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)	SLC3A2 MDU1	Homo sapiens (Human)	630	FUNCTION: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:11557028, PubMed:9829974, PubMed:9751058, PubMed:9878049, PubMed:10574970, PubMed:10903140, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:9829974, PubMed:10903140). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:11557028, PubMed:10574970, PubMed:11389679, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:15980244, PubMed:12716892, PubMed:33298890, PubMed:33758168, PubMed:30867591). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:15625115, PubMed:11121428). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}.		amino acid transport [GO:0006865]; calcium ion transport [GO:0006816]; carbohydrate metabolic process [GO:0005975]; isoleucine transport [GO:0015818]; L-alanine import across plasma membrane [GO:1904273]; L-histidine transport [GO:1902024]; L-leucine import across plasma membrane [GO:1903801]; leucine import across plasma membrane [GO:0098713]; leucine transport [GO:0015820]; methionine transport [GO:0015821]; phenylalanine transport [GO:0015823]; proline transport [GO:0015824]; response to exogenous dsRNA [GO:0043330]; thyroid hormone transport [GO:0070327]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828]; valine transport [GO:0015829]; viral entry into host cell [GO:0046718]	amino acid transport complex [GO:1990184]; anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; apical pole of neuron [GO:0044225]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202]	aromatic amino acid transmembrane transporter activity [GO:0015173]; cadherin binding [GO:0045296]; calcium:sodium antiporter activity [GO:0005432]; double-stranded RNA binding [GO:0003725]; exogenous protein binding [GO:0140272]; L-alanine transmembrane transporter activity [GO:0015180]; L-leucine transmembrane transporter activity [GO:0015190]; neutral L-amino acid secondary active transmembrane transporter activity [GO:0005294]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; virus receptor activity [GO:0001618]	amino acid transport complex [GO:1990184]; anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; apical pole of neuron [GO:0044225]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202]; aromatic amino acid transmembrane transporter activity [GO:0015173]; cadherin binding [GO:0045296]; calcium:sodium antiporter activity [GO:0005432]; double-stranded RNA binding [GO:0003725]; exogenous protein binding [GO:0140272]; L-alanine transmembrane transporter activity [GO:0015180]; L-leucine transmembrane transporter activity [GO:0015190]; neutral L-amino acid secondary active transmembrane transporter activity [GO:0005294]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; virus receptor activity [GO:0001618]; amino acid transport [GO:0006865]; calcium ion transport [GO:0006816]; carbohydrate metabolic process [GO:0005975]; isoleucine transport [GO:0015818]; L-alanine import across plasma membrane [GO:1904273]; L-histidine transport [GO:1902024]; L-leucine import across plasma membrane [GO:1903801]; leucine import across plasma membrane [GO:0098713]; leucine transport [GO:0015820]; methionine transport [GO:0015821]; phenylalanine transport [GO:0015823]; proline transport [GO:0015824]; response to exogenous dsRNA [GO:0043330]; thyroid hormone transport [GO:0070327]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828]; valine transport [GO:0015829]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11742812}. Cell membrane {ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:3476959, ECO:0000269|PubMed:3480538, ECO:0000269|PubMed:36028562, ECO:0000269|PubMed:9829974}; Single-pass type II membrane protein {ECO:0000269|PubMed:30867591}. Cell junction {ECO:0000250|UniProtKB:P10852}. Lysosome membrane {ECO:0000269|PubMed:25998567}. Melanosome {ECO:0000269|PubMed:17081065}. Basolateral cell membrane {ECO:0000250|UniProtKB:P10852}. Note=Localized at the plasma membrane when associated with SLC7A5/LAT1 or SLC7A8/LAT2 (PubMed:9751058, PubMed:11311135). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250|UniProtKB:P10852, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}.
P08217	reviewed	CEL2A_HUMAN	Chymotrypsin-like elastase family member 2A (EC 3.4.21.71) (Elastase-2A)	CELA2A ELA2A	Homo sapiens (Human)	269	FUNCTION: Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. {ECO:0000269|PubMed:31358993}.		insulin catabolic process [GO:1901143]; proteolysis [GO:0006508]; regulation of insulin secretion [GO:0050796]; regulation of platelet aggregation [GO:0090330]; response to insulin [GO:0032868]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; keratohyalin granule [GO:0036457]	endopeptidase activity [GO:0004175]; serine hydrolase activity [GO:0017171]; serine-type endopeptidase activity [GO:0004252]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; keratohyalin granule [GO:0036457]; endopeptidase activity [GO:0004175]; serine hydrolase activity [GO:0017171]; serine-type endopeptidase activity [GO:0004252]; insulin catabolic process [GO:1901143]; proteolysis [GO:0006508]; regulation of insulin secretion [GO:0050796]; regulation of platelet aggregation [GO:0090330]; response to insulin [GO:0032868]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31358993}.
P08218	reviewed	CEL2B_HUMAN	Chymotrypsin-like elastase family member 2B (EC 3.4.21.71) (Elastase-2B)	CELA2B ELA2B	Homo sapiens (Human)	269	FUNCTION: Acts upon elastin.		proteolysis [GO:0006508]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
P08235	reviewed	MCR_HUMAN	Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2)	NR3C2 MCR MLR	Homo sapiens (Human)	984	FUNCTION: Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}.	MISCELLANEOUS: [Isoform 2]: Lacks steroid-binding activity and acts as ligand-independent transactivator. {ECO:0000305}.	intracellular steroid hormone receptor signaling pathway [GO:0030518]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; receptor complex [GO:0043235]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; TBP-class protein binding [GO:0017025]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; receptor complex [GO:0043235]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; TBP-class protein binding [GO:0017025]; zinc ion binding [GO:0008270]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
P08236	reviewed	BGLR_HUMAN	Beta-glucuronidase (EC 3.2.1.31) (Beta-G1)	GUSB	Homo sapiens (Human)	651	FUNCTION: Plays an important role in the degradation of dermatan and keratan sulfates.		carbohydrate metabolic process [GO:0005975]; chondroitin sulfate catabolic process [GO:0030207]; glucuronoside catabolic process [GO:0019391]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; hyaluronan catabolic process [GO:0030214]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]	beta-glucuronidase activity [GO:0004566]; carbohydrate binding [GO:0030246]; protein domain specific binding [GO:0019904]; signaling receptor binding [GO:0005102]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; beta-glucuronidase activity [GO:0004566]; carbohydrate binding [GO:0030246]; protein domain specific binding [GO:0019904]; signaling receptor binding [GO:0005102]; carbohydrate metabolic process [GO:0005975]; chondroitin sulfate catabolic process [GO:0030207]; glucuronoside catabolic process [GO:0019391]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; hyaluronan catabolic process [GO:0030214]	SUBCELLULAR LOCATION: Lysosome.
P08237	reviewed	PFKAM_HUMAN	ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase)	PFKM PFKX	Homo sapiens (Human)	780	FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.	MISCELLANEOUS: In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes.	canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glucose homeostasis [GO:0042593]; glycogen catabolic process [GO:0005980]; glycolysis from storage polysaccharide through glucose-1-phosphate [GO:0093001]; glycolytic process [GO:0006096]; glycolytic process through fructose-6-phosphate [GO:0061615]; muscle cell cellular homeostasis [GO:0046716]; positive regulation of insulin secretion [GO:0032024]; positive regulation of transcription by RNA polymerase II [GO:0045944]	6-phosphofructokinase complex [GO:0005945]; apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; sperm principal piece [GO:0097228]	6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; fructose binding [GO:0070061]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]	6-phosphofructokinase complex [GO:0005945]; apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; sperm principal piece [GO:0097228]; 6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; fructose binding [GO:0070061]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]; canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glucose homeostasis [GO:0042593]; glycogen catabolic process [GO:0005980]; glycolysis from storage polysaccharide through glucose-1-phosphate [GO:0093001]; glycolytic process [GO:0006096]; glycolytic process through fructose-6-phosphate [GO:0061615]; muscle cell cellular homeostasis [GO:0046716]; positive regulation of insulin secretion [GO:0032024]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
P08238	reviewed	HS90B_HUMAN	Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84)	HSP90AB1 HSP90B HSPC2 HSPCB	Homo sapiens (Human)	724	FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}.		axon extension [GO:0048675]; cellular response to heat [GO:0034605]; cellular response to interleukin-4 [GO:0071353]; central nervous system neuron axonogenesis [GO:0021955]; chaperone-mediated protein complex assembly [GO:0051131]; establishment of cell polarity [GO:0030010]; negative regulation of apoptotic process [GO:0043066]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transforming growth factor beta activation [GO:1901389]; placenta development [GO:0001890]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cyclin-dependent protein kinase activity [GO:1904031]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of tau-protein kinase activity [GO:1902949]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986]; supramolecular fiber organization [GO:0097435]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance via telomerase [GO:0007004]; virion attachment to host cell [GO:0019062]	aryl hydrocarbon receptor complex [GO:0034751]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; dynein axonemal particle [GO:0120293]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; HSP90-CDC37 chaperone complex [GO:1990565]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein binding [GO:0043008]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; disordered domain specific binding [GO:0097718]; DNA polymerase binding [GO:0070182]; double-stranded RNA binding [GO:0003725]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; MHC class II protein complex binding [GO:0023026]; nitric-oxide synthase regulator activity [GO:0030235]; peptide binding [GO:0042277]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	aryl hydrocarbon receptor complex [GO:0034751]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; dynein axonemal particle [GO:0120293]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; HSP90-CDC37 chaperone complex [GO:1990565]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein binding [GO:0043008]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; disordered domain specific binding [GO:0097718]; DNA polymerase binding [GO:0070182]; double-stranded RNA binding [GO:0003725]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; MHC class II protein complex binding [GO:0023026]; nitric-oxide synthase regulator activity [GO:0030235]; peptide binding [GO:0042277]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; axon extension [GO:0048675]; cellular response to heat [GO:0034605]; cellular response to interleukin-4 [GO:0071353]; central nervous system neuron axonogenesis [GO:0021955]; chaperone-mediated protein complex assembly [GO:0051131]; establishment of cell polarity [GO:0030010]; negative regulation of apoptotic process [GO:0043066]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transforming growth factor beta activation [GO:1901389]; placenta development [GO:0001890]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cyclin-dependent protein kinase activity [GO:1904031]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of tau-protein kinase activity [GO:1902949]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986]; supramolecular fiber organization [GO:0097435]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance via telomerase [GO:0007004]; virion attachment to host cell [GO:0019062]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16580629, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:24880080, ECO:0000269|PubMed:9482106}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus {ECO:0000269|PubMed:18239673}. Secreted {ECO:0000269|PubMed:20599762}. Cell membrane {ECO:0000269|PubMed:20599762}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q6AZV1}. Cell surface {ECO:0000269|PubMed:21949862}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673). Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762). {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:20599762}.
P08240	reviewed	SRPRA_HUMAN	Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha)	SRPRA SRPR	Homo sapiens (Human)	638	FUNCTION: Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}.		cotranslational protein targeting to membrane [GO:0006613]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; signal recognition particle receptor complex [GO:0005785]	ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; signal recognition particle receptor complex [GO:0005785]; ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]; cotranslational protein targeting to membrane [GO:0006613]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32916}; Peripheral membrane protein {ECO:0000250|UniProtKB:P32916}; Cytoplasmic side {ECO:0000250|UniProtKB:P32916}. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain. {ECO:0000250|UniProtKB:P32916}.
P08243	reviewed	ASNS_HUMAN	Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) (Cell cycle control protein TS11) (Glutamine-dependent asparagine synthetase)	ASNS TS11	Homo sapiens (Human)	561			asparagine biosynthetic process [GO:0006529]; cellular response to glucose starvation [GO:0042149]; glutamine metabolic process [GO:0006541]; L-asparagine biosynthetic process [GO:0070981]; negative regulation of apoptotic process [GO:0043066]; positive regulation of mitotic cell cycle [GO:0045931]	cytosol [GO:0005829]	asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]; ATP binding [GO:0005524]	cytosol [GO:0005829]; asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]; ATP binding [GO:0005524]; asparagine biosynthetic process [GO:0006529]; cellular response to glucose starvation [GO:0042149]; glutamine metabolic process [GO:0006541]; L-asparagine biosynthetic process [GO:0070981]; negative regulation of apoptotic process [GO:0043066]; positive regulation of mitotic cell cycle [GO:0045931]	
P08246	reviewed	ELNE_HUMAN	Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase)	ELANE ELA2	Homo sapiens (Human)	267	FUNCTION: Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022). Promotes cleavage of GSDMB, thereby inhibiting pyroptosis (PubMed:36899106). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984). {ECO:0000269|PubMed:10947984, ECO:0000269|PubMed:15140022, ECO:0000269|PubMed:36899106}.		acute inflammatory response to antigenic stimulus [GO:0002438]; biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0002812]; defense response to bacterium [GO:0042742]; extracellular matrix disassembly [GO:0022617]; intracellular calcium ion homeostasis [GO:0006874]; leukocyte migration involved in inflammatory response [GO:0002523]; negative regulation of chemokine production [GO:0032682]; negative regulation of chemotaxis [GO:0050922]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neutrophil-mediated killing of fungus [GO:0070947]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; phagocytosis [GO:0006909]; positive regulation of immune response [GO:0050778]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; response to lipopolysaccharide [GO:0032496]; response to UV [GO:0009411]; response to yeast [GO:0001878]	azurophil granule lumen [GO:0035578]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle [GO:0045335]; secretory granule [GO:0030141]; specific granule lumen [GO:0035580]; transcription repressor complex [GO:0017053]	cytokine binding [GO:0019955]; endopeptidase activity [GO:0004175]; heparin binding [GO:0008201]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; transcription corepressor activity [GO:0003714]	azurophil granule lumen [GO:0035578]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle [GO:0045335]; secretory granule [GO:0030141]; specific granule lumen [GO:0035580]; transcription repressor complex [GO:0017053]; cytokine binding [GO:0019955]; endopeptidase activity [GO:0004175]; heparin binding [GO:0008201]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; transcription corepressor activity [GO:0003714]; acute inflammatory response to antigenic stimulus [GO:0002438]; biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0002812]; defense response to bacterium [GO:0042742]; extracellular matrix disassembly [GO:0022617]; intracellular calcium ion homeostasis [GO:0006874]; leukocyte migration involved in inflammatory response [GO:0002523]; negative regulation of chemokine production [GO:0032682]; negative regulation of chemotaxis [GO:0050922]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neutrophil-mediated killing of fungus [GO:0070947]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; phagocytosis [GO:0006909]; positive regulation of immune response [GO:0050778]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; response to lipopolysaccharide [GO:0032496]; response to UV [GO:0009411]; response to yeast [GO:0001878]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:10947984}. Note=Localized in phagolysosomes following ingestion of E.coli by neutrophils. {ECO:0000269|PubMed:10947984}.
P08247	reviewed	SYPH_HUMAN	Synaptophysin (Major synaptic vesicle protein p38)	SYP	Homo sapiens (Human)	313	FUNCTION: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). {ECO:0000250}.		cellular response to organic substance [GO:0071310]; endocytosis [GO:0006897]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of opioid receptor signaling pathway [GO:2000474]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle membrane organization [GO:0048499]	excitatory synapse [GO:0060076]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	cholesterol binding [GO:0015485]; identical protein binding [GO:0042802]; SH2 domain binding [GO:0042169]	excitatory synapse [GO:0060076]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; cholesterol binding [GO:0015485]; identical protein binding [GO:0042802]; SH2 domain binding [GO:0042169]; cellular response to organic substance [GO:0071310]; endocytosis [GO:0006897]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of opioid receptor signaling pathway [GO:2000474]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle membrane organization [GO:0048499]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:18662323}; Multi-pass membrane protein {ECO:0000255}. Synapse, synaptosome {ECO:0000269|PubMed:18662323}.
P08253	reviewed	MMP2_HUMAN	72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX]	MMP2 CLG4A	Homo sapiens (Human)	660	FUNCTION: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION: PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.; FUNCTION: [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.	MISCELLANEOUS: [Isoform 2]: Induced by oxidative stress. {ECO:0000305}.	angiogenesis [GO:0001525]; blood vessel maturation [GO:0001955]; bone trabecula formation [GO:0060346]; cellular response to amino acid stimulus [GO:0071230]; cellular response to estradiol stimulus [GO:0071392]; cellular response to fluid shear stress [GO:0071498]; cellular response to interleukin-1 [GO:0071347]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; embryo implantation [GO:0007566]; endodermal cell differentiation [GO:0035987]; ephrin receptor signaling pathway [GO:0048013]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; heart development [GO:0007507]; intramembranous ossification [GO:0001957]; luteinization [GO:0001553]; macrophage chemotaxis [GO:0048246]; negative regulation of cell adhesion [GO:0007162]; negative regulation of vasoconstriction [GO:0045906]; ovarian follicle development [GO:0001541]; ovulation from ovarian follicle [GO:0001542]; parturition [GO:0007567]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostate gland epithelium morphogenesis [GO:0060740]; protein catabolic process [GO:0030163]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]; response to activity [GO:0014823]; response to amyloid-beta [GO:1904645]; response to electrical stimulus [GO:0051602]; response to estrogen [GO:0043627]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to nicotine [GO:0035094]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; tissue remodeling [GO:0048771]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcomere [GO:0030017]	endopeptidase activity [GO:0004175]; fibronectin binding [GO:0001968]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcomere [GO:0030017]; endopeptidase activity [GO:0004175]; fibronectin binding [GO:0001968]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; angiogenesis [GO:0001525]; blood vessel maturation [GO:0001955]; bone trabecula formation [GO:0060346]; cellular response to amino acid stimulus [GO:0071230]; cellular response to estradiol stimulus [GO:0071392]; cellular response to fluid shear stress [GO:0071498]; cellular response to interleukin-1 [GO:0071347]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; embryo implantation [GO:0007566]; endodermal cell differentiation [GO:0035987]; ephrin receptor signaling pathway [GO:0048013]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; heart development [GO:0007507]; intramembranous ossification [GO:0001957]; luteinization [GO:0001553]; macrophage chemotaxis [GO:0048246]; negative regulation of cell adhesion [GO:0007162]; negative regulation of vasoconstriction [GO:0045906]; ovarian follicle development [GO:0001541]; ovulation from ovarian follicle [GO:0001542]; parturition [GO:0007567]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostate gland epithelium morphogenesis [GO:0060740]; protein catabolic process [GO:0030163]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]; response to activity [GO:0014823]; response to amyloid-beta [GO:1904645]; response to electrical stimulus [GO:0051602]; response to estrogen [GO:0043627]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to nicotine [GO:0035094]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; tissue remodeling [GO:0048771]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:2834383}. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Mitochondrion.
P08254	reviewed	MMP3_HUMAN	Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1)	MMP3 STMY1	Homo sapiens (Human)	477	FUNCTION: Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9 (PubMed:11029580, PubMed:1371271). Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway (PubMed:2383557). Acts also intracellularly (PubMed:22265821). For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage (PubMed:21330369). In addition, plays a role in immune response and possesses antiviral activity against various viruses such as vesicular stomatitis virus, influenza A virus (H1N1) and human herpes virus 1 (PubMed:35940311). Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities (PubMed:35940311). {ECO:0000269|PubMed:11029580, ECO:0000269|PubMed:1371271, ECO:0000269|PubMed:21330369, ECO:0000269|PubMed:22265821, ECO:0000269|PubMed:2383557, ECO:0000269|PubMed:35940311}.		cellular response to lipopolysaccharide [GO:0071222]; cellular response to nitric oxide [GO:0071732]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; innate immune response [GO:0045087]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein-containing complex assembly [GO:0031334]; proteolysis [GO:0006508]; regulation of neuroinflammatory response [GO:0150077]; response to amyloid-beta [GO:1904645]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]	endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nitric oxide [GO:0071732]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; innate immune response [GO:0045087]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein-containing complex assembly [GO:0031334]; proteolysis [GO:0006508]; regulation of neuroinflammatory response [GO:0150077]; response to amyloid-beta [GO:1904645]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Nucleus {ECO:0000269|PubMed:35940311}. Cytoplasm {ECO:0000269|PubMed:35940311}.
P08263	reviewed	GSTA1_HUMAN	Glutathione S-transferase A1 (EC 2.5.1.18) (13-hydroperoxyoctadecadienoate peroxidase) (EC 1.11.1.-) (Androst-5-ene-3,17-dione isomerase) (EC 5.3.3.-) (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1) [Cleaved into: Glutathione S-transferase A1, N-terminally processed]	GSTA1	Homo sapiens (Human)	222	FUNCTION: Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487). {ECO:0000269|PubMed:11152686, ECO:0000269|PubMed:16624487, ECO:0000269|PubMed:9084911, ECO:0000305|PubMed:20606271}.		epithelial cell differentiation [GO:0030855]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; linoleic acid metabolic process [GO:0043651]; prostaglandin metabolic process [GO:0006693]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	fatty acid binding [GO:0005504]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; steroid delta-isomerase activity [GO:0004769]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fatty acid binding [GO:0005504]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; steroid delta-isomerase activity [GO:0004769]; epithelial cell differentiation [GO:0030855]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; linoleic acid metabolic process [GO:0043651]; prostaglandin metabolic process [GO:0006693]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm.
P08294	reviewed	SODE_HUMAN	Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1)	SOD3	Homo sapiens (Human)	240	FUNCTION: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.		blood vessel diameter maintenance [GO:0097746]; removal of superoxide radicals [GO:0019430]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]	copper ion binding [GO:0005507]; heparin binding [GO:0008201]; molecular adaptor activity [GO:0060090]; superoxide dismutase activity [GO:0004784]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; copper ion binding [GO:0005507]; heparin binding [GO:0008201]; molecular adaptor activity [GO:0060090]; superoxide dismutase activity [GO:0004784]; blood vessel diameter maintenance [GO:0097746]; removal of superoxide radicals [GO:0019430]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Secreted, extracellular space. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O09164}. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.
P08311	reviewed	CATG_HUMAN	Cathepsin G (CG) (EC 3.4.21.20) [Cleaved into: Cathepsin G, C-terminal truncated form]	CTSG	Homo sapiens (Human)	255	FUNCTION: Serine protease with trypsin- and chymotrypsin-like specificity (PubMed:8194606, PubMed:29652924). Also displays antibacterial activity against Gram-negative and Gram-positive bacteria independent of its protease activity (PubMed:2116408, PubMed:2117044). Prefers Phe and Tyr residues in the P1 position of substrates but also cleaves efficiently after Trp and Leu (PubMed:29652924). Shows a preference for negatively charged amino acids in the P2' position and for aliphatic amino acids both upstream and downstream of the cleavage site (PubMed:29652924). Required for recruitment and activation of platelets which is mediated by the F2RL3/PAR4 platelet receptor (PubMed:3390156, PubMed:10702240). Binds reversibly to and stimulates B cells and CD4(+) and CD8(+) T cells (PubMed:7842483, PubMed:9000539). Also binds reversibly to natural killer (NK) cells and enhances NK cell cytotoxicity through its protease activity (PubMed:9000539, PubMed:9536127). Cleaves complement C3 (PubMed:1861080). Cleaves vimentin (By similarity). Cleaves thrombin receptor F2R/PAR1 and acts as either an agonist or an inhibitor, depending on the F2R cleavage site (PubMed:10702240, PubMed:7744748). Cleavage of F2R at '41-Arg-|-Ser-42' results in receptor activation while cleavage at '55-Phe-|-Trp-56' results in inhibition of receptor activation (PubMed:7744748). Cleaves the synovial mucin-type protein PRG4/lubricin (PubMed:32144329). Cleaves and activates IL36G which promotes expression of chemokines CXCL1 and CXLC8 in keratinocytes (PubMed:30804664). Cleaves IL33 into mature forms which have greater activity than the unprocessed form (PubMed:22307629). Cleaves coagulation factor F8 to produce a partially activated form (PubMed:18217133). Also cleaves and activates coagulation factor F10 (PubMed:8920993). Cleaves leukocyte cell surface protein SPN/CD43 to releases its extracellular domain and trigger its intramembrane proteolysis by gamma-secretase, releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus (PubMed:18586676). Cleaves CCL5/RANTES to produce RANTES(4-68) lacking the N-terminal three amino acids which exhibits reduced chemotactic and antiviral activities (PubMed:16963625). During apoptosis, cleaves SMARCA2/BRM to produce a 160 kDa cleavage product which localizes to the cytosol (PubMed:11259672). Cleaves myelin basic protein MBP in B cell lysosomes at '224-Phe-|-Lys-225' and '248-Phe-|-Ser-249', degrading the major immunogenic MBP epitope and preventing the activation of MBP-specific autoreactive T cells (PubMed:15100291). Cleaves annexin ANXA1 and antimicrobial peptide CAMP to produce peptides which act on neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). Acts as a ligand for the N-formyl peptide receptor FPR1, enhancing phagocyte chemotaxis (PubMed:15210802). Has antibacterial activity against the Gram-negative bacteria N.gonorrhoeae and P.aeruginosa (PubMed:2116408, PubMed:1937776). Likely to act against N.gonorrhoeae by interacting with N.gonorrhoeae penA/PBP2 (PubMed:2126324). Exhibits potent antimicrobial activity against the Gram-positive bacterium L.monocytogenes (PubMed:2117044). Has antibacterial activity against the Gram-positive bacterium S.aureus and degrades S.aureus biofilms, allowing polymorphonuclear leukocytes to penetrate the biofilm and phagocytose bacteria (PubMed:2117044, PubMed:32995850). Has antibacterial activity against M.tuberculosis (PubMed:15385470). Mediates CASP4 activation induced by the Td92 surface protein of the periodontal pathogen T.denticola, causing production and secretion of IL1A and leading to pyroptosis of gingival fibroblasts (PubMed:29077095). {ECO:0000250|UniProtKB:P28293, ECO:0000269|PubMed:10702240, ECO:0000269|PubMed:11259672, ECO:0000269|PubMed:15100291, ECO:0000269|PubMed:15210802, ECO:0000269|PubMed:15385470, ECO:0000269|PubMed:16963625, ECO:0000269|PubMed:18217133, ECO:0000269|PubMed:18586676, ECO:0000269|PubMed:1861080, ECO:0000269|PubMed:1937776, ECO:0000269|PubMed:2116408, ECO:0000269|PubMed:2117044, ECO:0000269|PubMed:2126324, ECO:0000269|PubMed:22307629, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:29077095, ECO:0000269|PubMed:29652924, ECO:0000269|PubMed:30804664, ECO:0000269|PubMed:32144329, ECO:0000269|PubMed:32995850, ECO:0000269|PubMed:3390156, ECO:0000269|PubMed:7744748, ECO:0000269|PubMed:7842483, ECO:0000269|PubMed:8194606, ECO:0000269|PubMed:8920993, ECO:0000269|PubMed:9000539, ECO:0000269|PubMed:9536127}.		angiotensin maturation [GO:0002003]; antibacterial humoral response [GO:0019731]; biofilm matrix disassembly [GO:0098786]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; monocyte chemotaxis [GO:0002548]; negative regulation of T cell activation [GO:0050868]; neutrophil activation [GO:0042119]; neutrophil-mediated killing of gram-positive bacterium [GO:0070946]; platelet activation [GO:0030168]; positive regulation of immune response [GO:0050778]; positive regulation of platelet aggregation [GO:1901731]; protein metabolic process [GO:0019538]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; proteolysis [GO:0006508]; purinergic nucleotide receptor signaling pathway [GO:0035590]	azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]	caspase binding [GO:0089720]; heparin binding [GO:0008201]; peptidase activity [GO:0008233]; receptor ligand activity [GO:0048018]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; caspase binding [GO:0089720]; heparin binding [GO:0008201]; peptidase activity [GO:0008233]; receptor ligand activity [GO:0048018]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; angiotensin maturation [GO:0002003]; antibacterial humoral response [GO:0019731]; biofilm matrix disassembly [GO:0098786]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; monocyte chemotaxis [GO:0002548]; negative regulation of T cell activation [GO:0050868]; neutrophil activation [GO:0042119]; neutrophil-mediated killing of gram-positive bacterium [GO:0070946]; platelet activation [GO:0030168]; positive regulation of immune response [GO:0050778]; positive regulation of platelet aggregation [GO:1901731]; protein metabolic process [GO:0019538]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; proteolysis [GO:0006508]; purinergic nucleotide receptor signaling pathway [GO:0035590]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15100291, ECO:0000269|PubMed:29077095, ECO:0000269|PubMed:8194606}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic granule {ECO:0000269|PubMed:7499346}. Secreted {ECO:0000269|PubMed:29077095, ECO:0000269|PubMed:32144329, ECO:0000269|PubMed:3390156}. Cytoplasm, cytosol {ECO:0000269|PubMed:29077095}. Lysosome {ECO:0000269|PubMed:15100291, ECO:0000269|PubMed:29077095}. Nucleus {ECO:0000269|PubMed:11259672}. Note=Secreted by activated neutrophils (PubMed:3390156). Detected in synovial fluid (PubMed:32144329). Localizes to lysosomes in B cells where it is not endogenously synthesized but is internalized from the cell membrane (PubMed:15100291). Localizes to the nucleus during apoptosis (PubMed:11259672). {ECO:0000269|PubMed:11259672, ECO:0000269|PubMed:15100291, ECO:0000269|PubMed:32144329, ECO:0000269|PubMed:3390156}.
P08319	reviewed	ADH4_HUMAN	All-trans-retinol dehydrogenase [NAD(+)] ADH4 (EC 1.1.1.105) (Alcohol dehydrogenase 2) (Alcohol dehydrogenase 4) (Alcohol dehydrogenase class II pi chain)	ADH4 ADH2	Homo sapiens (Human)	380	FUNCTION: Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444). {ECO:0000269|PubMed:10514444, ECO:0000269|PubMed:16081420, ECO:0000269|PubMed:17279314}.	MISCELLANEOUS: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.	alcohol catabolic process [GO:0046164]; alcohol metabolic process [GO:0006066]; cellular aldehyde metabolic process [GO:0006081]; ethanol oxidation [GO:0006069]; fatty acid omega-oxidation [GO:0010430]; formaldehyde catabolic process [GO:0046294]; quinone metabolic process [GO:1901661]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	alcohol dehydrogenase (NAD+) activity [GO:0004022]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; all-trans retinal binding [GO:0005503]; benzaldehyde dehydrogenase [NAD(P)+] activity [GO:0019115]; NAD binding [GO:0051287]; NAD-retinol dehydrogenase activity [GO:0004745]; NADPH:quinone reductase activity [GO:0003960]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; retinol binding [GO:0019841]; S-(hydroxymethyl)glutathione dehydrogenase activity [GO:0051903]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; alcohol dehydrogenase (NAD+) activity [GO:0004022]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; all-trans retinal binding [GO:0005503]; benzaldehyde dehydrogenase [NAD(P)+] activity [GO:0019115]; NAD binding [GO:0051287]; NAD-retinol dehydrogenase activity [GO:0004745]; NADPH:quinone reductase activity [GO:0003960]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; retinol binding [GO:0019841]; S-(hydroxymethyl)glutathione dehydrogenase activity [GO:0051903]; zinc ion binding [GO:0008270]; alcohol catabolic process [GO:0046164]; alcohol metabolic process [GO:0006066]; cellular aldehyde metabolic process [GO:0006081]; ethanol oxidation [GO:0006069]; fatty acid omega-oxidation [GO:0010430]; formaldehyde catabolic process [GO:0046294]; quinone metabolic process [GO:1901661]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]	SUBCELLULAR LOCATION: Cytoplasm.
P08397	reviewed	HEM3_HUMAN	Porphobilinogen deaminase (PBG-D) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase)	HMBS PBGD UPS	Homo sapiens (Human)	361	FUNCTION: As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen (PubMed:18936296, PubMed:19138865, PubMed:23815679, PubMed:18004775). Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact (PubMed:18936296). {ECO:0000269|PubMed:18004775, ECO:0000269|PubMed:18936296, ECO:0000269|PubMed:19138865, ECO:0000269|PubMed:23815679}.		heme biosynthetic process [GO:0006783]; protoporphyrinogen IX biosynthetic process [GO:0006782]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	hydroxymethylbilane synthase activity [GO:0004418]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; hydroxymethylbilane synthase activity [GO:0004418]; heme biosynthetic process [GO:0006783]; protoporphyrinogen IX biosynthetic process [GO:0006782]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P08473	reviewed	NEP_HUMAN	Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10)	MME EPN	Homo sapiens (Human)	750	FUNCTION: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:6349683, PubMed:6208535, PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:6349683, PubMed:17101991). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (PubMed:6208535). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:6349683, PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:2531377, PubMed:2972276, PubMed:16254193). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). {ECO:0000269|PubMed:15283675, ECO:0000269|PubMed:17101991, ECO:0000269|PubMed:20876573, ECO:0000269|PubMed:2531377, ECO:0000269|PubMed:27588448, ECO:0000269|PubMed:2972276, ECO:0000269|PubMed:6208535, ECO:0000269|PubMed:6349683}.	MISCELLANEOUS: Important cell surface marker in the diagnostic of human acute lymphocytic leukemia. {ECO:0000269|PubMed:2528730, ECO:0000269|PubMed:2968607, ECO:0000269|PubMed:2971756}.	amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta metabolic process [GO:0050435]; bradykinin catabolic process [GO:0010815]; cellular response to cytokine stimulus [GO:0071345]; cellular response to UV-A [GO:0071492]; cellular response to UV-B [GO:0071493]; creatinine metabolic process [GO:0046449]; hormone catabolic process [GO:0042447]; kidney development [GO:0001822]; learning or memory [GO:0007611]; lung development [GO:0030324]; neuropeptide processing [GO:0061837]; peptide metabolic process [GO:0006518]; placenta development [GO:0001890]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neurogenesis [GO:0050769]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; replicative senescence [GO:0090399]; response to estrogen [GO:0043627]; sensory perception of pain [GO:0019233]; substance P catabolic process [GO:0010814]	axon [GO:0030424]; brush border [GO:0005903]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]	cardiolipin binding [GO:1901612]; endopeptidase activity [GO:0004175]; exopeptidase activity [GO:0008238]; metalloendopeptidase activity [GO:0004222]; oligopeptidase activity [GO:0070012]; peptide binding [GO:0042277]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	axon [GO:0030424]; brush border [GO:0005903]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; cardiolipin binding [GO:1901612]; endopeptidase activity [GO:0004175]; exopeptidase activity [GO:0008238]; metalloendopeptidase activity [GO:0004222]; oligopeptidase activity [GO:0070012]; peptide binding [GO:0042277]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta metabolic process [GO:0050435]; bradykinin catabolic process [GO:0010815]; cellular response to cytokine stimulus [GO:0071345]; cellular response to UV-A [GO:0071492]; cellular response to UV-B [GO:0071493]; creatinine metabolic process [GO:0046449]; hormone catabolic process [GO:0042447]; kidney development [GO:0001822]; learning or memory [GO:0007611]; lung development [GO:0030324]; neuropeptide processing [GO:0061837]; peptide metabolic process [GO:0006518]; placenta development [GO:0001890]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neurogenesis [GO:0050769]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; replicative senescence [GO:0090399]; response to estrogen [GO:0043627]; sensory perception of pain [GO:0019233]; substance P catabolic process [GO:0010814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20876573}; Single-pass type II membrane protein {ECO:0000255}.
P08476	reviewed	INHBA_HUMAN	Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF)	INHBA	Homo sapiens (Human)	426	FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.		activin receptor signaling pathway [GO:0032924]; cardiac fibroblast cell development [GO:0060936]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; cellular response to cholesterol [GO:0071397]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; endodermal cell differentiation [GO:0035987]; erythrocyte differentiation [GO:0030218]; extrinsic apoptotic signaling pathway [GO:0097191]; eyelid development in camera-type eye [GO:0061029]; GABAergic neuron differentiation [GO:0097154]; hair follicle development [GO:0001942]; hematopoietic progenitor cell differentiation [GO:0002244]; hemoglobin biosynthetic process [GO:0042541]; male gonad development [GO:0008584]; mesodermal cell differentiation [GO:0048333]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of phosphorylation [GO:0042326]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; odontogenesis [GO:0042476]; ovarian follicle development [GO:0001541]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of gene expression [GO:0010628]; positive regulation of ovulation [GO:0060279]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; progesterone secretion [GO:0042701]; regulation of follicle-stimulating hormone secretion [GO:0046880]; regulation of transcription by RNA polymerase II [GO:0006357]; response to aldosterone [GO:1904044]; roof of mouth development [GO:0060021]; striatal medium spiny neuron differentiation [GO:0021773]; transcription by RNA polymerase II [GO:0006366]	activin A complex [GO:0043509]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; inhibin A complex [GO:0043512]; perinuclear region of cytoplasm [GO:0048471]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; peptide hormone binding [GO:0017046]; protein-containing complex binding [GO:0044877]; type II activin receptor binding [GO:0070699]	activin A complex [GO:0043509]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; inhibin A complex [GO:0043512]; perinuclear region of cytoplasm [GO:0048471]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; peptide hormone binding [GO:0017046]; protein-containing complex binding [GO:0044877]; type II activin receptor binding [GO:0070699]; activin receptor signaling pathway [GO:0032924]; cardiac fibroblast cell development [GO:0060936]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; cellular response to cholesterol [GO:0071397]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; endodermal cell differentiation [GO:0035987]; erythrocyte differentiation [GO:0030218]; extrinsic apoptotic signaling pathway [GO:0097191]; eyelid development in camera-type eye [GO:0061029]; GABAergic neuron differentiation [GO:0097154]; hair follicle development [GO:0001942]; hematopoietic progenitor cell differentiation [GO:0002244]; hemoglobin biosynthetic process [GO:0042541]; male gonad development [GO:0008584]; mesodermal cell differentiation [GO:0048333]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of phosphorylation [GO:0042326]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; odontogenesis [GO:0042476]; ovarian follicle development [GO:0001541]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of gene expression [GO:0010628]; positive regulation of ovulation [GO:0060279]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; progesterone secretion [GO:0042701]; regulation of follicle-stimulating hormone secretion [GO:0046880]; regulation of transcription by RNA polymerase II [GO:0006357]; response to aldosterone [GO:1904044]; roof of mouth development [GO:0060021]; striatal medium spiny neuron differentiation [GO:0021773]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Secreted.
P08493	reviewed	MGP_HUMAN	Matrix Gla protein (MGP) (Cell growth-inhibiting gene 36 protein)	MGP MGLAP GIG36	Homo sapiens (Human)	103	FUNCTION: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.		cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; ossification [GO:0001503]; regulation of bone mineralization [GO:0030500]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; structural constituent of bone [GO:0008147]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; structural constituent of bone [GO:0008147]; cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; ossification [GO:0001503]; regulation of bone mineralization [GO:0030500]	SUBCELLULAR LOCATION: Secreted.
P08514	reviewed	ITA2B_HUMAN	Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]	ITGA2B GP2B ITGAB	Homo sapiens (Human)	1039	FUNCTION: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.		angiogenesis [GO:0001525]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of leukocyte migration [GO:0002687]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	extracellular matrix binding [GO:0050840]; fibrinogen binding [GO:0070051]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; extracellular matrix binding [GO:0050840]; fibrinogen binding [GO:0070051]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; angiogenesis [GO:0001525]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of leukocyte migration [GO:0002687]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P08519	reviewed	APOA_HUMAN	Apolipoprotein(a) (Apo(a)) (Lp(a)) (EC 3.4.21.-)	LPA	Homo sapiens (Human)	2040	FUNCTION: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. {ECO:0000269|PubMed:2531657}.	MISCELLANEOUS: Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding.	blood circulation [GO:0008015]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma lipoprotein particle [GO:0034358]	apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; endopeptidase inhibitor activity [GO:0004866]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma lipoprotein particle [GO:0034358]; apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; endopeptidase inhibitor activity [GO:0004866]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]; blood circulation [GO:0008015]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; proteolysis [GO:0006508]	
P08559	reviewed	ODPA_HUMAN	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	PDHA1 PHE1A	Homo sapiens (Human)	390	FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:19081061, ECO:0000269|PubMed:7782287}.		acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099]	mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pyruvate dehydrogenase complex [GO:0045254]	pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]; pyruvate dehydrogenase (NAD+) activity [GO:0034604]	mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pyruvate dehydrogenase complex [GO:0045254]; pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]; pyruvate dehydrogenase (NAD+) activity [GO:0034604]; acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P08567	reviewed	PLEK_HUMAN	Pleckstrin (Platelet 47 kDa protein) (p47)	PLEK P47	Homo sapiens (Human)	350	FUNCTION: Major protein kinase C substrate of platelets.		actin cytoskeleton organization [GO:0030036]; cell projection organization [GO:0030030]; cortical actin cytoskeleton organization [GO:0030866]; hematopoietic progenitor cell differentiation [GO:0002244]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of calcium-mediated signaling [GO:0050849]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of inositol phosphate biosynthetic process [GO:0010920]; phosphatidylinositol metabolic process [GO:0046488]; phospholipase C-inhibiting G protein-coupled receptor signaling pathway [GO:0030845]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of inositol-polyphosphate 5-phosphatase activity [GO:0010925]; positive regulation of integrin activation [GO:0033625]; positive regulation of platelet activation [GO:0010572]; protein kinase C signaling [GO:0070528]; protein secretion by platelet [GO:0070560]; regulation of cell diameter [GO:0060305]; ruffle organization [GO:0031529]; thrombin-activated receptor signaling pathway [GO:0070493]; vesicle docking involved in exocytosis [GO:0006904]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; actin cytoskeleton organization [GO:0030036]; cell projection organization [GO:0030030]; cortical actin cytoskeleton organization [GO:0030866]; hematopoietic progenitor cell differentiation [GO:0002244]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of calcium-mediated signaling [GO:0050849]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of inositol phosphate biosynthetic process [GO:0010920]; phosphatidylinositol metabolic process [GO:0046488]; phospholipase C-inhibiting G protein-coupled receptor signaling pathway [GO:0030845]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of inositol-polyphosphate 5-phosphatase activity [GO:0010925]; positive regulation of integrin activation [GO:0033625]; positive regulation of platelet activation [GO:0010572]; protein kinase C signaling [GO:0070528]; protein secretion by platelet [GO:0070560]; regulation of cell diameter [GO:0060305]; ruffle organization [GO:0031529]; thrombin-activated receptor signaling pathway [GO:0070493]; vesicle docking involved in exocytosis [GO:0006904]	
P08571	reviewed	CD14_HUMAN	Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]	CD14	Homo sapiens (Human)	375	FUNCTION: Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655, PubMed:22265692). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). {ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:20133493, ECO:0000269|PubMed:22265692, ECO:0000269|PubMed:23264655, ECO:0000269|PubMed:23880187, ECO:0000269|PubMed:8612135}.		apoptotic process [GO:0006915]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; cell surface receptor signaling pathway [GO:0007166]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to molecule of bacterial origin [GO:0071219]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; phagocytosis [GO:0006909]; positive regulation of cytokine production [GO:0001819]; positive regulation of endocytosis [GO:0045807]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type II interferon production [GO:0032729]; receptor-mediated endocytosis [GO:0006898]; response to electrical stimulus [GO:0051602]; response to ethanol [GO:0045471]; response to magnesium ion [GO:0032026]; response to tumor necrosis factor [GO:0034612]; toll-like receptor 4 signaling pathway [GO:0034142]	endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; lipopolysaccharide receptor complex [GO:0046696]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; lipoteichoic acid binding [GO:0070891]; opsonin receptor activity [GO:0001847]; peptidoglycan immune receptor activity [GO:0016019]	endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; lipopolysaccharide receptor complex [GO:0046696]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; lipoteichoic acid binding [GO:0070891]; opsonin receptor activity [GO:0001847]; peptidoglycan immune receptor activity [GO:0016019]; apoptotic process [GO:0006915]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; cell surface receptor signaling pathway [GO:0007166]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to molecule of bacterial origin [GO:0071219]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; phagocytosis [GO:0006909]; positive regulation of cytokine production [GO:0001819]; positive regulation of endocytosis [GO:0045807]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type II interferon production [GO:0032729]; receptor-mediated endocytosis [GO:0006898]; response to electrical stimulus [GO:0051602]; response to ethanol [GO:0045471]; response to magnesium ion [GO:0032026]; response to tumor necrosis factor [GO:0034612]; toll-like receptor 4 signaling pathway [GO:0034142]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:3385210}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:3385210}. Secreted {ECO:0000269|PubMed:25497142, ECO:0000269|PubMed:2779588}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus {ECO:0000269|PubMed:16880211}. Note=Secreted forms may arise by cleavage of the GPI anchor. {ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:2779588, ECO:0000269|PubMed:3385210}.
P08572	reviewed	CO4A2_HUMAN	Collagen alpha-2(IV) chain [Cleaved into: Canstatin]	COL4A2	Homo sapiens (Human)	1712	FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.		angiogenesis [GO:0001525]; cellular response to transforming growth factor beta stimulus [GO:0071560]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; DNA-templated transcription [GO:0006351]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; negative regulation of angiogenesis [GO:0016525]; response to activity [GO:0014823]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; molecular adaptor activity [GO:0060090]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; molecular adaptor activity [GO:0060090]; angiogenesis [GO:0001525]; cellular response to transforming growth factor beta stimulus [GO:0071560]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; DNA-templated transcription [GO:0006351]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; negative regulation of angiogenesis [GO:0016525]; response to activity [GO:0014823]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
P08574	reviewed	CY1_HUMAN	Cytochrome c1, heme protein, mitochondrial (EC 7.1.1.8) (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)	CYC1	Homo sapiens (Human)	325	FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c. {ECO:0000250|UniProtKB:P07143}.		cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; response to glucagon [GO:0033762]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	heme binding [GO:0020037]; metal ion binding [GO:0046872]; ubiquinol-cytochrome-c reductase activity [GO:0008121]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; response to glucagon [GO:0033762]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07143}; Single-pass membrane protein {ECO:0000250|UniProtKB:P07143}.
P08575	reviewed	PTPRC_HUMAN	Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)	PTPRC CD45	Homo sapiens (Human)	1306	FUNCTION: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:2845400}.; FUNCTION: (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. {ECO:0000269|PubMed:22174689}.		alpha-beta T cell proliferation [GO:0046633]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; bone marrow development [GO:0048539]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell cycle phase transition [GO:0044770]; cell surface receptor signaling pathway [GO:0007166]; cellular response to extracellular stimulus [GO:0031668]; defense response to virus [GO:0051607]; dephosphorylation [GO:0016311]; DN2 thymocyte differentiation [GO:1904155]; extrinsic apoptotic signaling pathway [GO:0097191]; gamma-delta T cell differentiation [GO:0042492]; hematopoietic progenitor cell differentiation [GO:0002244]; heterotypic cell-cell adhesion [GO:0034113]; leukocyte cell-cell adhesion [GO:0007159]; MAPK cascade [GO:0000165]; natural killer cell differentiation [GO:0001779]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative thymic T cell selection [GO:0045060]; plasma membrane raft distribution [GO:0044855]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of antigen receptor-mediated signaling pathway [GO:0050857]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein tyrosine phosphatase activity [GO:1903615]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; positive thymic T cell selection [GO:0045059]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of interleukin-8 production [GO:0032677]; regulation of phagocytosis [GO:0050764]; regulation of protein tyrosine kinase activity [GO:0061097]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; release of sequestered calcium ion into cytosol [GO:0051209]; response to aldosterone [GO:1904044]; response to gamma radiation [GO:0010332]; stem cell development [GO:0048864]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]	bleb [GO:0032059]; cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane microdomain [GO:0098857]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	ankyrin binding [GO:0030506]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; signaling receptor binding [GO:0005102]; spectrin binding [GO:0030507]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	bleb [GO:0032059]; cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane microdomain [GO:0098857]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; ankyrin binding [GO:0030506]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; signaling receptor binding [GO:0005102]; spectrin binding [GO:0030507]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; alpha-beta T cell proliferation [GO:0046633]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; bone marrow development [GO:0048539]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell cycle phase transition [GO:0044770]; cell surface receptor signaling pathway [GO:0007166]; cellular response to extracellular stimulus [GO:0031668]; defense response to virus [GO:0051607]; dephosphorylation [GO:0016311]; DN2 thymocyte differentiation [GO:1904155]; extrinsic apoptotic signaling pathway [GO:0097191]; gamma-delta T cell differentiation [GO:0042492]; hematopoietic progenitor cell differentiation [GO:0002244]; heterotypic cell-cell adhesion [GO:0034113]; leukocyte cell-cell adhesion [GO:0007159]; MAPK cascade [GO:0000165]; natural killer cell differentiation [GO:0001779]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative thymic T cell selection [GO:0045060]; plasma membrane raft distribution [GO:0044855]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of antigen receptor-mediated signaling pathway [GO:0050857]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein tyrosine phosphatase activity [GO:1903615]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; positive thymic T cell selection [GO:0045059]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of interleukin-8 production [GO:0032677]; regulation of phagocytosis [GO:0050764]; regulation of protein tyrosine kinase activity [GO:0061097]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; release of sequestered calcium ion into cytosol [GO:0051209]; response to aldosterone [GO:1904044]; response to gamma radiation [GO:0010332]; stem cell development [GO:0048864]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12676959, ECO:0000269|PubMed:22174689}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:12676959}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:12676959}.
P08579	reviewed	RU2B_HUMAN	U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'')	SNRPB2	Homo sapiens (Human)	225	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9716128}.	MISCELLANEOUS: Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins.	mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; cytoplasmic ribonucleoprotein granule [GO:0036464]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]	snRNP binding [GO:0070990]; U1 snRNA binding [GO:0030619]	catalytic step 2 spliceosome [GO:0071013]; cytoplasmic ribonucleoprotein granule [GO:0036464]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; snRNP binding [GO:0070990]; U1 snRNA binding [GO:0030619]; mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}.
P08581	reviewed	MET_HUMAN	Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)	MET	Homo sapiens (Human)	1390	FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). {ECO:0000250|UniProtKB:P16056}.; FUNCTION: (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. {ECO:0000269|PubMed:11081636, ECO:0000305|PubMed:17662939, ECO:0000305|PubMed:19900460}.		branching morphogenesis of an epithelial tube [GO:0048754]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; endothelial cell morphogenesis [GO:0001886]; establishment of skin barrier [GO:0061436]; liver development [GO:0001889]; negative regulation of autophagy [GO:0010507]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; phagocytosis [GO:0006909]; phosphorylation [GO:0016310]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of transcription by RNA polymerase II [GO:0045944]; semaphorin-plexin signaling pathway [GO:0071526]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	basal plasma membrane [GO:0009925]; cell surface [GO:0009986]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; hepatocyte growth factor receptor activity [GO:0005008]; identical protein binding [GO:0042802]; molecular function activator activity [GO:0140677]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; semaphorin receptor activity [GO:0017154]	basal plasma membrane [GO:0009925]; cell surface [GO:0009986]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; hepatocyte growth factor receptor activity [GO:0005008]; identical protein binding [GO:0042802]; molecular function activator activity [GO:0140677]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; semaphorin receptor activity [GO:0017154]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; endothelial cell morphogenesis [GO:0001886]; establishment of skin barrier [GO:0061436]; liver development [GO:0001889]; negative regulation of autophagy [GO:0010507]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; phagocytosis [GO:0006909]; phosphorylation [GO:0016310]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of transcription by RNA polymerase II [GO:0045944]; semaphorin-plexin signaling pathway [GO:0071526]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
P08582	reviewed	TRFM_HUMAN	Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228)	MELTF MAP97 MFI2	Homo sapiens (Human)	738	FUNCTION: Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. {ECO:0000269|PubMed:7556058}.		iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of plasminogen activation [GO:0010756]	cell surface [GO:0009986]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; side of membrane [GO:0098552]	iron ion binding [GO:0005506]	cell surface [GO:0009986]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; side of membrane [GO:0098552]; iron ion binding [GO:0005506]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of plasminogen activation [GO:0010756]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.
P08588	reviewed	ADRB1_HUMAN	Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor)	ADRB1 ADRB1R B1AR	Homo sapiens (Human)	477	FUNCTION: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062). {ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:31473062}.		adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; brown fat cell differentiation [GO:0050873]; diet induced thermogenesis [GO:0002024]; fear response [GO:0042596]; heat generation [GO:0031649]; negative regulation of multicellular organism growth [GO:0040015]; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002025]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of GTPase activity [GO:0043547]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of the force of heart contraction by epinephrine-norepinephrine [GO:0001997]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; response to cold [GO:0009409]	early endosome [GO:0005769]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]	alpha-2A adrenergic receptor binding [GO:0031694]; beta-adrenergic receptor activity [GO:0004939]; beta1-adrenergic receptor activity [GO:0004940]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [GO:0099579]; PDZ domain binding [GO:0030165]; protein heterodimerization activity [GO:0046982]	early endosome [GO:0005769]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; alpha-2A adrenergic receptor binding [GO:0031694]; beta-adrenergic receptor activity [GO:0004939]; beta1-adrenergic receptor activity [GO:0004940]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [GO:0099579]; PDZ domain binding [GO:0030165]; protein heterodimerization activity [GO:0046982]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; brown fat cell differentiation [GO:0050873]; diet induced thermogenesis [GO:0002024]; fear response [GO:0042596]; heat generation [GO:0031649]; negative regulation of multicellular organism growth [GO:0040015]; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002025]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of GTPase activity [GO:0043547]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of the force of heart contraction by epinephrine-norepinephrine [GO:0001997]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; response to cold [GO:0009409]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18090}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18090}. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. {ECO:0000250}.
P08590	reviewed	MYL3_HUMAN	Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb)	MYL3	Homo sapiens (Human)	195	FUNCTION: Regulatory light chain of myosin. Does not bind calcium.		cardiac muscle contraction [GO:0060048]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of striated muscle contraction [GO:0006942]; regulation of the force of heart contraction [GO:0002026]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	A band [GO:0031672]; cytosol [GO:0005829]; I band [GO:0031674]; muscle myosin complex [GO:0005859]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]	actin monomer binding [GO:0003785]; calcium ion binding [GO:0005509]; myosin II heavy chain binding [GO:0032038]; structural constituent of muscle [GO:0008307]	A band [GO:0031672]; cytosol [GO:0005829]; I band [GO:0031674]; muscle myosin complex [GO:0005859]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; actin monomer binding [GO:0003785]; calcium ion binding [GO:0005509]; myosin II heavy chain binding [GO:0032038]; structural constituent of muscle [GO:0008307]; cardiac muscle contraction [GO:0060048]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of striated muscle contraction [GO:0006942]; regulation of the force of heart contraction [GO:0002026]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	
P08603	reviewed	CFAH_HUMAN	Complement factor H (H factor 1)	CFH HF HF1 HF2	Homo sapiens (Human)	1231	FUNCTION: Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces (PubMed:21285368, PubMed:25402769). Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop (PubMed:19503104, PubMed:26700768). As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b (PubMed:23332154, PubMed:18252712, PubMed:28671664). In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed (PubMed:9558116, PubMed:20008295). {ECO:0000269|PubMed:18252712, ECO:0000269|PubMed:19503104, ECO:0000269|PubMed:20008295, ECO:0000269|PubMed:21285368, ECO:0000269|PubMed:23332154, ECO:0000269|PubMed:25402769, ECO:0000269|PubMed:26700768, ECO:0000269|PubMed:28671664, ECO:0000269|PubMed:9558116}.; FUNCTION: (Microbial infection) In the mosquito midgut, binds to the surface of parasite P.falciparum gametocytes and protects the parasite from alternative complement pathway-mediated elimination. {ECO:0000269|PubMed:23332154}.		complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; proteolysis [GO:0006508]; regulation of complement activation [GO:0030449]; regulation of complement activation, alternative pathway [GO:0030451]; regulation of complement-dependent cytotoxicity [GO:1903659]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370]; symbiont cell surface [GO:0106139]	complement component C3b binding [GO:0001851]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370]; symbiont cell surface [GO:0106139]; complement component C3b binding [GO:0001851]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; proteolysis [GO:0006508]; regulation of complement activation [GO:0030449]; regulation of complement activation, alternative pathway [GO:0030451]; regulation of complement-dependent cytotoxicity [GO:1903659]	SUBCELLULAR LOCATION: Secreted.; SUBCELLULAR LOCATION: Note=(Microbial infection) In the mosquito midgut, localizes to P.falciparum (NF54 strain) macrogamete and young zygote cell membranes. {ECO:0000269|PubMed:23332154}.
P08620	reviewed	FGF4_HUMAN	Fibroblast growth factor 4 (FGF-4) (Heparin secretory-transforming protein 1) (HST) (HST-1) (HSTF-1) (Heparin-binding growth factor 4) (HBGF-4) (Transforming protein KS3)	FGF4 HST HSTF1 KS3	Homo sapiens (Human)	206	FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells (By similarity). {ECO:0000250|UniProtKB:P11403, ECO:0000269|PubMed:8663044}.	MISCELLANEOUS: [Isoform 2]: Antagonist of isoform 1, shutting down FGF4-induced Erk1/2 phosphorylation. {ECO:0000305}.	animal organ morphogenesis [GO:0009887]; apoptotic process involved in morphogenesis [GO:0060561]; cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; cellular response to leukemia inhibitory factor [GO:1990830]; chondroblast differentiation [GO:0060591]; cranial suture morphogenesis [GO:0060363]; embryonic hindlimb morphogenesis [GO:0035116]; epithelial cell apoptotic process [GO:1904019]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mesenchymal cell proliferation [GO:0010463]; negative regulation of apoptotic process [GO:0043066]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell migration [GO:0030334]; regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000544]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; stem cell proliferation [GO:0072089]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; animal organ morphogenesis [GO:0009887]; apoptotic process involved in morphogenesis [GO:0060561]; cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; cellular response to leukemia inhibitory factor [GO:1990830]; chondroblast differentiation [GO:0060591]; cranial suture morphogenesis [GO:0060363]; embryonic hindlimb morphogenesis [GO:0035116]; epithelial cell apoptotic process [GO:1904019]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mesenchymal cell proliferation [GO:0010463]; negative regulation of apoptotic process [GO:0043066]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell migration [GO:0030334]; regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000544]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P08621	reviewed	RU17_HUMAN	U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)	SNRNP70 RNPU1Z RPU1 SNRP70 U1AP1	Homo sapiens (Human)	437	FUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158). {ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2467746, ECO:0000269|PubMed:25555158}.; FUNCTION: [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.; FUNCTION: [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.	MISCELLANEOUS: Major ribonucleoprotein antigen recognized by the sera from patients with autoimmune diseases, such as systemic lupus erythematosus.	mRNA splicing, via spliceosome [GO:0000398]; negative regulation of chaperone-mediated autophagy [GO:1904715]; negative regulation of protein refolding [GO:0061084]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of ATP-dependent activity [GO:0043462]; regulation of RNA splicing [GO:0043484]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of chaperone-mediated autophagy [GO:1904715]; negative regulation of protein refolding [GO:0061084]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of ATP-dependent activity [GO:0043462]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:17656373}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17656373, ECO:0000269|PubMed:21113136}. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250|UniProtKB:Q62376}.
P08631	reviewed	HCK_HUMAN	Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)	HCK	Homo sapiens (Human)	526	FUNCTION: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}.	MISCELLANEOUS: [Isoform 1]: Initiates from a CTG codon.; MISCELLANEOUS: [Isoform 4]: Initiates from a CTG codon. {ECO:0000305}.	cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cytokine-mediated signaling pathway [GO:0019221]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; innate immune response-activating signaling pathway [GO:0002758]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; leukocyte degranulation [GO:0043299]; leukocyte migration involved in immune response [GO:0002522]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; localization [GO:0051179]; mesoderm development [GO:0007498]; negative regulation of apoptotic process [GO:0043066]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell population proliferation [GO:0008284]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of inflammatory response [GO:0050727]; regulation of phagocytosis [GO:0050764]; regulation of podosome assembly [GO:0071801]; respiratory burst after phagocytosis [GO:0045728]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; type II interferon-mediated signaling pathway [GO:0060333]	caveola [GO:0005901]; cell projection [GO:0042995]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]	ATP binding [GO:0005524]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]	caveola [GO:0005901]; cell projection [GO:0042995]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; ATP binding [GO:0005524]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cytokine-mediated signaling pathway [GO:0019221]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; innate immune response-activating signaling pathway [GO:0002758]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; leukocyte degranulation [GO:0043299]; leukocyte migration involved in immune response [GO:0002522]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; localization [GO:0051179]; mesoderm development [GO:0007498]; negative regulation of apoptotic process [GO:0043066]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell population proliferation [GO:0008284]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of inflammatory response [GO:0050727]; regulation of phagocytosis [GO:0050764]; regulation of podosome assembly [GO:0071801]; respiratory burst after phagocytosis [GO:0045728]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; type II interferon-mediated signaling pathway [GO:0060333]	SUBCELLULAR LOCATION: [Isoform 1]: Lysosome. Membrane; Lipid-anchor. Cell projection, podosome membrane; Lipid-anchor. Cytoplasm, cytosol. Note=Associated with specialized secretory lysosomes called azurophil granules. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11904303}; Lipid-anchor {ECO:0000269|PubMed:11904303}. Membrane, caveola {ECO:0000269|PubMed:11904303}; Lipid-anchor {ECO:0000269|PubMed:11904303}. Cell junction, focal adhesion {ECO:0000269|PubMed:11904303}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11904303}. Golgi apparatus {ECO:0000269|PubMed:11904303}. Cytoplasmic vesicle {ECO:0000269|PubMed:11904303}. Lysosome {ECO:0000269|PubMed:11904303}. Nucleus {ECO:0000269|PubMed:11904303}. Note=20% of this isoform is associated with caveolae. Localization at the cell membrane and at caveolae requires palmitoylation at Cys-3. Colocalizes with the actin cytoskeleton at focal adhesions.; SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol.
P08637	reviewed	FCG3A_HUMAN	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)	FCGR3A CD16A FCG3 FCGR3 IGFR3	Homo sapiens (Human)	254	FUNCTION: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (PubMed:24412922, PubMed:25786175, PubMed:21768335, PubMed:22023369, PubMed:8609432, PubMed:9242542, PubMed:25816339, PubMed:11711607, PubMed:28652325). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC (PubMed:25786175, PubMed:24412922). Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (PubMed:9916693, PubMed:29967280). Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation. The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation (PubMed:2532305, PubMed:1825220, PubMed:23024279). Costimulates NK cells and trigger lysis of target cells independently of IgG binding (PubMed:23006327, PubMed:10318937). Mediates the antitumor activities of therapeutic antibodies. Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (PubMed:27670158). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821). {ECO:0000269|PubMed:10318937, ECO:0000269|PubMed:11711607, ECO:0000269|PubMed:1825220, ECO:0000269|PubMed:21768335, ECO:0000269|PubMed:22023369, ECO:0000269|PubMed:23006327, ECO:0000269|PubMed:23024279, ECO:0000269|PubMed:24412922, ECO:0000269|PubMed:2532305, ECO:0000269|PubMed:25786175, ECO:0000269|PubMed:25816339, ECO:0000269|PubMed:27670158, ECO:0000269|PubMed:29967280, ECO:0000269|PubMed:34485821, ECO:0000269|PubMed:8609432, ECO:0000269|PubMed:9242542, ECO:0000269|PubMed:9916693}.; FUNCTION: (Microbial infection) Involved in Dengue virus pathogenesis via antibody-dependent enhancement (ADE) mechanism. Secondary infection with Dengue virus triggers elevated levels of afucosylated non-neutralizing IgG1s with reactivity to viral envelope/E protein. Viral antigen-IgG1 complexes bind with high affinity to FCGR3A, facilitating virus entry in myeloid cells and subsequent viral replication. {ECO:0000269|PubMed:28126818}.	MISCELLANEOUS: Encoded by one of two nearly identical genes: FCGR3A (shown here) and FCGR3B which are expressed in a tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the 'Ser-203' in III-B determines the GPI-anchoring.; MISCELLANEOUS: FCGR3A in mammals is the true ortholog of FCGR4 in rodents. The FCGR2A-HSPA6-FCGR4-FCGR2B module was duplicated in great apes through non-allelic homologous recombination, giving rise to two FCGR4-type genes and to FCGR2C, a hybrid gene combining FCGR2A and FCGR2B. While FCGR3A kept the original FCGR4 functionality, FCGR3B rapidly evolved and acquired specific features coding for a GPI-anchored receptor. {ECO:0000269|PubMed:31244843}.	antibody-dependent cellular cytotoxicity [GO:0001788]; calcium-mediated signaling [GO:0019722]; cell surface receptor signaling pathway [GO:0007166]; Fc-gamma receptor signaling pathway [GO:0038094]; immune response [GO:0006955]; macrophage activation [GO:0042116]; natural killer cell activation [GO:0030101]; natural killer cell degranulation [GO:0043320]; natural killer cell mediated cytotoxicity [GO:0042267]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of immune response [GO:0050776]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Fc-gamma receptor III complex [GO:0033001]; plasma membrane [GO:0005886]	IgG binding [GO:0019864]; immune receptor activity [GO:0140375]; low-affinity IgG receptor activity [GO:0019772]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Fc-gamma receptor III complex [GO:0033001]; plasma membrane [GO:0005886]; IgG binding [GO:0019864]; immune receptor activity [GO:0140375]; low-affinity IgG receptor activity [GO:0019772]; transmembrane signaling receptor activity [GO:0004888]; antibody-dependent cellular cytotoxicity [GO:0001788]; calcium-mediated signaling [GO:0019722]; cell surface receptor signaling pathway [GO:0007166]; Fc-gamma receptor signaling pathway [GO:0038094]; immune response [GO:0006955]; macrophage activation [GO:0042116]; natural killer cell activation [GO:0030101]; natural killer cell degranulation [GO:0043320]; natural killer cell mediated cytotoxicity [GO:0042267]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1825220, ECO:0000269|PubMed:23006327, ECO:0000269|PubMed:24337742, ECO:0000269|PubMed:2532305, ECO:0000269|PubMed:28652325, ECO:0000269|PubMed:29967280}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:25816339, ECO:0000269|PubMed:29967280}. Note=Exists also as a soluble receptor. {ECO:0000269|PubMed:25816339, ECO:0000269|PubMed:29967280}.
P08648	reviewed	ITA5_HUMAN	Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]	ITGA5 FNRA	Homo sapiens (Human)	1049	FUNCTION: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:33962943}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. {ECO:0000269|PubMed:12907437}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. {ECO:0000269|PubMed:24478423}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.		angiogenesis [GO:0001525]; CD40 signaling pathway [GO:0023035]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; endodermal cell differentiation [GO:0035987]; female pregnancy [GO:0007565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; memory [GO:0007613]; negative regulation of anoikis [GO:2000811]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; wound healing, spreading of epidermal cells [GO:0035313]	alphav-beta3 integrin-vitronectin complex [GO:0071062]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; integrin alpha5-beta1 complex [GO:0034674]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; ruffle [GO:0001726]	epidermal growth factor receptor binding [GO:0005154]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor receptor binding [GO:0005161]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; virus receptor activity [GO:0001618]	alphav-beta3 integrin-vitronectin complex [GO:0071062]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; integrin alpha5-beta1 complex [GO:0034674]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; ruffle [GO:0001726]; epidermal growth factor receptor binding [GO:0005154]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor receptor binding [GO:0005161]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; virus receptor activity [GO:0001618]; angiogenesis [GO:0001525]; CD40 signaling pathway [GO:0023035]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; endodermal cell differentiation [GO:0035987]; female pregnancy [GO:0007565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; memory [GO:0007613]; negative regulation of anoikis [GO:2000811]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17158881}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}.
P08651	reviewed	NFIC_HUMAN	Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)	NFIC NFI	Homo sapiens (Human)	508	FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.		DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
P08670	reviewed	VIME_HUMAN	Vimentin	VIM	Homo sapiens (Human)	466	FUNCTION: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. {ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}.		astrocyte development [GO:0014002]; Bergmann glial cell differentiation [GO:0060020]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to type II interferon [GO:0071346]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307]; negative regulation of neuron projection development [GO:0010977]; neuron projection development [GO:0031175]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of translation [GO:0045727]; regulation of mRNA stability [GO:0043488]; SMAD protein signal transduction [GO:0060395]	axon [GO:0030424]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; microtubule organizing center [GO:0005815]; nuclear matrix [GO:0016363]; peroxisome [GO:0005777]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]	double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; keratin filament binding [GO:1990254]; molecular adaptor activity [GO:0060090]; protein domain specific binding [GO:0019904]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212]	axon [GO:0030424]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; microtubule organizing center [GO:0005815]; nuclear matrix [GO:0016363]; peroxisome [GO:0005777]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; keratin filament binding [GO:1990254]; molecular adaptor activity [GO:0060090]; protein domain specific binding [GO:0019904]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212]; astrocyte development [GO:0014002]; Bergmann glial cell differentiation [GO:0060020]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to type II interferon [GO:0071346]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307]; negative regulation of neuron projection development [GO:0010977]; neuron projection development [GO:0031175]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of translation [GO:0045727]; regulation of mRNA stability [GO:0043488]; SMAD protein signal transduction [GO:0060395]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:29496907}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18408015, ECO:0000269|PubMed:29496907}. Nucleus matrix {ECO:0000250|UniProtKB:P31000}. Cell membrane {ECO:0000250|UniProtKB:P20152}.
P08684	reviewed	CP3A4_HUMAN	Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55)	CYP3A4 CYP3A3	Homo sapiens (Human)	503	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15373842, PubMed:15764715, PubMed:20702771, PubMed:19965576, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:2732228, PubMed:14559847, PubMed:12865317, PubMed:15373842, PubMed:15764715, PubMed:21576599, PubMed:21490593). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:14559847, PubMed:12865317). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:2732228, PubMed:15373842, PubMed:15764715, PubMed:22773874). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:2732228, PubMed:15373842, PubMed:15764715). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}.	MISCELLANEOUS: Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664). {ECO:0000305|PubMed:11726664}.	aflatoxin metabolic process [GO:0046222]; alkaloid catabolic process [GO:0009822]; androgen metabolic process [GO:0008209]; cholesterol metabolic process [GO:0008203]; estrogen metabolic process [GO:0008210]; heterocycle metabolic process [GO:0046483]; lipid hydroxylation [GO:0002933]; lipid metabolic process [GO:0006629]; long-chain fatty acid biosynthetic process [GO:0042759]; monoterpenoid metabolic process [GO:0016098]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; steroid metabolic process [GO:0008202]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	1,8-cineole 2-exo-monooxygenase activity [GO:0102320]; 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity [GO:0062181]; anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; aromatase activity [GO:0070330]; caffeine oxidase activity [GO:0034875]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxygen binding [GO:0019825]; quinine 3-monooxygenase activity [GO:0050591]; retinoic acid 4-hydroxylase activity [GO:0008401]; steroid binding [GO:0005496]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]; vitamin D 24-hydroxylase activity [GO:0070576]; vitamin D3 25-hydroxylase activity [GO:0030343]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; 1,8-cineole 2-exo-monooxygenase activity [GO:0102320]; 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity [GO:0062181]; anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; aromatase activity [GO:0070330]; caffeine oxidase activity [GO:0034875]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxygen binding [GO:0019825]; quinine 3-monooxygenase activity [GO:0050591]; retinoic acid 4-hydroxylase activity [GO:0008401]; steroid binding [GO:0005496]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]; vitamin D 24-hydroxylase activity [GO:0070576]; vitamin D3 25-hydroxylase activity [GO:0030343]; aflatoxin metabolic process [GO:0046222]; alkaloid catabolic process [GO:0009822]; androgen metabolic process [GO:0008209]; cholesterol metabolic process [GO:0008203]; estrogen metabolic process [GO:0008210]; heterocycle metabolic process [GO:0046483]; lipid hydroxylation [GO:0002933]; lipid metabolic process [GO:0006629]; long-chain fatty acid biosynthetic process [GO:0042759]; monoterpenoid metabolic process [GO:0016098]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; steroid metabolic process [GO:0008202]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane {ECO:0000269|PubMed:21576599}; Single-pass membrane protein.
P08686	reviewed	CP21A_HUMAN	Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) (Cytochrome P450-C21B)	CYP21A2 CYP21 CYP21B	Homo sapiens (Human)	494	FUNCTION: A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:25855791, PubMed:10602386, PubMed:16984992, PubMed:22014889, PubMed:27721825). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791). {ECO:0000269|PubMed:10602386, ECO:0000269|PubMed:16984992, ECO:0000269|PubMed:22014889, ECO:0000269|PubMed:25855791, ECO:0000269|PubMed:27721825}.		glucocorticoid biosynthetic process [GO:0006704]; mineralocorticoid biosynthetic process [GO:0006705]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; sterol metabolic process [GO:0016125]	endoplasmic reticulum membrane [GO:0005789]	17-hydroxyprogesterone 21-hydroxylase activity [GO:0103069]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; progesterone 21-hydroxylase activity [GO:0106309]; steroid 21-monooxygenase activity [GO:0004509]; steroid binding [GO:0005496]; steroid hydroxylase activity [GO:0008395]	endoplasmic reticulum membrane [GO:0005789]; 17-hydroxyprogesterone 21-hydroxylase activity [GO:0103069]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; progesterone 21-hydroxylase activity [GO:0106309]; steroid 21-monooxygenase activity [GO:0004509]; steroid binding [GO:0005496]; steroid hydroxylase activity [GO:0008395]; glucocorticoid biosynthetic process [GO:0006704]; mineralocorticoid biosynthetic process [GO:0006705]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; sterol metabolic process [GO:0016125]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000269|PubMed:10198222}. Microsome membrane {ECO:0000269|PubMed:10198222}; Peripheral membrane protein {ECO:0000269|PubMed:10198222}.
P08697	reviewed	A2AP_HUMAN	Alpha-2-antiplasmin (Alpha-2-AP) (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Serpin F2)	SERPINF2 AAP PLI	Homo sapiens (Human)	491	FUNCTION: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. {ECO:0000269|PubMed:15853774}.		acute-phase response [GO:0006953]; blood vessel morphogenesis [GO:0048514]; collagen fibril organization [GO:0030199]; fibrinolysis [GO:0042730]; maintenance of blood vessel diameter homeostasis by renin-angiotensin [GO:0002034]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta production [GO:0071636]; response to organic substance [GO:0010033]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; platelet alpha granule lumen [GO:0031093]	endopeptidase inhibitor activity [GO:0004866]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase inhibitor activity [GO:0004867]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; platelet alpha granule lumen [GO:0031093]; endopeptidase inhibitor activity [GO:0004866]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase inhibitor activity [GO:0004867]; acute-phase response [GO:0006953]; blood vessel morphogenesis [GO:0048514]; collagen fibril organization [GO:0030199]; fibrinolysis [GO:0042730]; maintenance of blood vessel diameter homeostasis by renin-angiotensin [GO:0002034]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta production [GO:0071636]; response to organic substance [GO:0010033]	SUBCELLULAR LOCATION: Secreted.
P08700	reviewed	IL3_HUMAN	Interleukin-3 (IL-3) (Hematopoietic growth factor) (Mast cell growth factor) (MCGF) (Multipotential colony-stimulating factor) (P-cell-stimulating factor)	IL3	Homo sapiens (Human)	152	FUNCTION: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:2556442). Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated (PubMed:10779277, PubMed:32889153). In addition, plays an important role in neural cell proliferation and survival (PubMed:23226269). Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation (PubMed:12816992). Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (PubMed:29374162). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (By similarity). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (PubMed:27862234). {ECO:0000250|UniProtKB:P01586, ECO:0000269|PubMed:10779277, ECO:0000269|PubMed:12816992, ECO:0000269|PubMed:23226269, ECO:0000269|PubMed:2556442, ECO:0000269|PubMed:27862234, ECO:0000269|PubMed:29374162, ECO:0000269|PubMed:32889153}.		cell-cell signaling [GO:0007267]; embryonic hemopoiesis [GO:0035162]; immune response [GO:0006955]; interleukin-3-mediated signaling pathway [GO:0038156]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-3 receptor binding [GO:0005135]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-3 receptor binding [GO:0005135]; cell-cell signaling [GO:0007267]; embryonic hemopoiesis [GO:0035162]; immune response [GO:0006955]; interleukin-3-mediated signaling pathway [GO:0038156]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]	SUBCELLULAR LOCATION: Secreted.
P08708	reviewed	RS17_HUMAN	Small ribosomal subunit protein eS17 (40S ribosomal protein S17)	RPS17 RPS17L	Homo sapiens (Human)	135	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; erythrocyte homeostasis [GO:0034101]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; erythrocyte homeostasis [GO:0034101]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
P08709	reviewed	FA7_HUMAN	Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain]	F7	Homo sapiens (Human)	466	FUNCTION: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.		animal organ regeneration [GO:0031100]; blood coagulation [GO:0007596]; circadian rhythm [GO:0007623]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell migration [GO:0030335]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet-derived growth factor receptor signaling pathway [GO:0010641]; positive regulation of positive chemotaxis [GO:0050927]; protein processing [GO:0016485]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]; response to astaxanthin [GO:1905217]; response to carbon dioxide [GO:0010037]; response to cholesterol [GO:0070723]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to genistein [GO:0033595]; response to growth hormone [GO:0060416]; response to hypoxia [GO:0001666]; response to Thyroid stimulating hormone [GO:1904400]; response to thyrotropin-releasing hormone [GO:1905225]; response to thyroxine [GO:0097068]; response to vitamin K [GO:0032571]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; serine-type peptidase complex [GO:1905286]; vesicle [GO:0031982]	calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; serine-type peptidase complex [GO:1905286]; vesicle [GO:0031982]; calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102]; animal organ regeneration [GO:0031100]; blood coagulation [GO:0007596]; circadian rhythm [GO:0007623]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell migration [GO:0030335]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet-derived growth factor receptor signaling pathway [GO:0010641]; positive regulation of positive chemotaxis [GO:0050927]; protein processing [GO:0016485]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]; response to astaxanthin [GO:1905217]; response to carbon dioxide [GO:0010037]; response to cholesterol [GO:0070723]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to genistein [GO:0033595]; response to growth hormone [GO:0060416]; response to hypoxia [GO:0001666]; response to Thyroid stimulating hormone [GO:1904400]; response to thyrotropin-releasing hormone [GO:1905225]; response to thyroxine [GO:0097068]; response to vitamin K [GO:0032571]	SUBCELLULAR LOCATION: Secreted.
P08727	reviewed	K1C19_HUMAN	Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)	KRT19	Homo sapiens (Human)	400	FUNCTION: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	cell differentiation involved in embryonic placenta development [GO:0060706]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; Notch signaling pathway [GO:0007219]; response to estrogen [GO:0043627]; sarcomere organization [GO:0045214]	apicolateral plasma membrane [GO:0016327]; cell periphery [GO:0071944]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; terminal web [GO:1990357]; Z disc [GO:0030018]	structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]	apicolateral plasma membrane [GO:0016327]; cell periphery [GO:0071944]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; terminal web [GO:1990357]; Z disc [GO:0030018]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; cell differentiation involved in embryonic placenta development [GO:0060706]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; Notch signaling pathway [GO:0007219]; response to estrogen [GO:0043627]; sarcomere organization [GO:0045214]	
P08729	reviewed	K2C7_HUMAN	Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)	KRT7 SCL	Homo sapiens (Human)	469	FUNCTION: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). {ECO:0000269|PubMed:10492017, ECO:0000269|PubMed:12072504}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nucleus [GO:0005634]	structural constituent of skin epidermis [GO:0030280]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nucleus [GO:0005634]; structural constituent of skin epidermis [GO:0030280]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:2459129}.
P08754	reviewed	GNAI3_HUMAN	Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)	GNAI3	Homo sapiens (Human)	354	FUNCTION: Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). {ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:8774883}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell cycle [GO:0007049]; cell division [GO:0051301]; dopamine receptor signaling pathway [GO:0007212]; GTP metabolic process [GO:0046039]; negative regulation of adenylate cyclase activity [GO:0007194]; positive regulation of macroautophagy [GO:0016239]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell cycle [GO:0007049]; cell division [GO:0051301]; dopamine receptor signaling pathway [GO:0007212]; GTP metabolic process [GO:0046039]; negative regulation of adenylate cyclase activity [GO:0007194]; positive regulation of macroautophagy [GO:0016239]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:27864364}; Lipid-anchor {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. {ECO:0000269|PubMed:17635935}.
P08758	reviewed	ANXA5_HUMAN	Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha)	ANXA5 ANX5 ENX2 PP4	Homo sapiens (Human)	320	FUNCTION: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.		blood coagulation [GO:0007596]; negative regulation of apoptotic process [GO:0043066]; negative regulation of coagulation [GO:0050819]; response to organic substance [GO:0010033]; signal transduction [GO:0007165]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endothelial microparticle [GO:0072563]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; sarcolemma [GO:0042383]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786]; phospholipase inhibitor activity [GO:0004859]; phospholipid binding [GO:0005543]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endothelial microparticle [GO:0072563]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; sarcolemma [GO:0042383]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786]; phospholipase inhibitor activity [GO:0004859]; phospholipid binding [GO:0005543]; blood coagulation [GO:0007596]; negative regulation of apoptotic process [GO:0043066]; negative regulation of coagulation [GO:0050819]; response to organic substance [GO:0010033]; signal transduction [GO:0007165]	
P08779	reviewed	K1C16_HUMAN	Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16)	KRT16 KRT16A	Homo sapiens (Human)	473	FUNCTION: Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. {ECO:0000250|UniProtKB:Q9Z2K1}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; establishment of skin barrier [GO:0061436]; hair cycle [GO:0042633]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; keratinocyte migration [GO:0051546]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cell migration [GO:0030336]	cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; nucleus [GO:0005634]	structural constituent of cytoskeleton [GO:0005200]	cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; nucleus [GO:0005634]; structural constituent of cytoskeleton [GO:0005200]; cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; establishment of skin barrier [GO:0061436]; hair cycle [GO:0042633]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; keratinocyte migration [GO:0051546]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cell migration [GO:0030336]	
P08833	reviewed	IBP1_HUMAN	Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12)	IGFBP1 IBP1	Homo sapiens (Human)	259	FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. {ECO:0000269|PubMed:15972819}.		insulin receptor signaling pathway [GO:0008286]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of cell growth [GO:0030307]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]; tissue regeneration [GO:0042246]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]	insulin-like growth factor binding [GO:0005520]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102]; insulin receptor signaling pathway [GO:0008286]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of cell growth [GO:0030307]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Secreted.
P08842	reviewed	STS_HUMAN	Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Estrone sulfatase) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase)	STS ARSC1	Homo sapiens (Human)	583	FUNCTION: Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. {ECO:0000269|PubMed:10844566, ECO:0000269|PubMed:23466819, ECO:0000269|PubMed:9252398}.		epidermis development [GO:0008544]; female pregnancy [GO:0007565]; steroid catabolic process [GO:0006706]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]	arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; steryl-sulfatase activity [GO:0004773]; sulfuric ester hydrolase activity [GO:0008484]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; steryl-sulfatase activity [GO:0004773]; sulfuric ester hydrolase activity [GO:0008484]; epidermis development [GO:0008544]; female pregnancy [GO:0007565]; steroid catabolic process [GO:0006706]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, microneme membrane {ECO:0000269|PubMed:2668275}; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:2668275}; Multi-pass membrane protein.
P08861	reviewed	CEL3B_HUMAN	Chymotrypsin-like elastase family member 3B (EC 3.4.21.70) (Elastase IIIB) (Elastase-3B) (Protease E)	CELA3B ELA3B	Homo sapiens (Human)	270	FUNCTION: Efficient protease with alanine specificity but only little elastolytic activity.		proteolysis [GO:0006508]	extracellular space [GO:0005615]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	extracellular space [GO:0005615]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	
P08865	reviewed	RSSA_HUMAN	Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4)	RPSA LAMBR LAMR1	Homo sapiens (Human)	295	FUNCTION: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:6300843}.; FUNCTION: (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. {ECO:0000269|PubMed:16973587}.; FUNCTION: (Microbial infection) Acts as a receptor for the Dengue virus. {ECO:0000269|PubMed:15507651}.; FUNCTION: (Microbial infection) Acts as a receptor for the Sindbis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the pathogenic prion protein. {ECO:0000269|PubMed:11689427, ECO:0000269|PubMed:9396609}.; FUNCTION: (Microbial infection) Acts as a receptor for bacteria. {ECO:0000269|PubMed:15516338}.	MISCELLANEOUS: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.; MISCELLANEOUS: It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.	cell adhesion [GO:0007155]; cytoplasmic translation [GO:0002181]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	laminin binding [GO:0043236]; laminin receptor activity [GO:0005055]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; virus receptor activity [GO:0001618]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; laminin binding [GO:0043236]; laminin receptor activity [GO:0005055]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; virus receptor activity [GO:0001618]; cell adhesion [GO:0007155]; cytoplasmic translation [GO:0002181]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cell membrane. Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255|HAMAP-Rule:MF_03016}.
P08887	reviewed	IL6RA_HUMAN	Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)]	IL6R	Homo sapiens (Human)	468	FUNCTION: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (PubMed:30995492, PubMed:31235509). The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). {ECO:0000269|PubMed:28265003, ECO:0000269|PubMed:31235509, ECO:0000305|PubMed:30995492}.; FUNCTION: [Isoform 1]: Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (By similarity). {ECO:0000250|UniProtKB:P22272, ECO:0000305|PubMed:30995492}.; FUNCTION: [Isoform 2]: Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:21990364). The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed:21990364). In complex with IL6, is required for induction of VEGF production (PubMed:12794819). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity). {ECO:0000250|UniProtKB:P22272, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:21990364}.; FUNCTION: [Soluble interleukin-6 receptor subunit alpha]: Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:21990364). The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed:21990364). In complex with IL6, is required for induction of VEGF production (PubMed:12794819). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity). {ECO:0000250|UniProtKB:P22272, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:21990364}.		acute-phase response [GO:0006953]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; endocrine pancreas development [GO:0031018]; extrinsic apoptotic signaling pathway [GO:0097191]; hepatic immune response [GO:0002384]; interleukin-6-mediated signaling pathway [GO:0070102]; monocyte chemotaxis [GO:0002548]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of interleukin-8 production [GO:0032717]; neutrophil mediated immunity [GO:0002446]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to cytokine [GO:0034097]; T-helper 17 cell lineage commitment [GO:0072540]; vascular endothelial growth factor production [GO:0010573]	apical plasma membrane [GO:0016324]; ciliary neurotrophic factor receptor complex [GO:0070110]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ciliary neurotrophic factor binding [GO:0070119]; cytokine receptor activity [GO:0004896]; enzyme binding [GO:0019899]; interleukin-11 binding [GO:0019970]; interleukin-11 receptor activity [GO:0004921]; interleukin-6 binding [GO:0019981]; interleukin-6 receptor activity [GO:0004915]; protein homodimerization activity [GO:0042803]	apical plasma membrane [GO:0016324]; ciliary neurotrophic factor receptor complex [GO:0070110]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ciliary neurotrophic factor binding [GO:0070119]; cytokine receptor activity [GO:0004896]; enzyme binding [GO:0019899]; interleukin-11 binding [GO:0019970]; interleukin-11 receptor activity [GO:0004921]; interleukin-6 binding [GO:0019981]; interleukin-6 receptor activity [GO:0004915]; protein homodimerization activity [GO:0042803]; acute-phase response [GO:0006953]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; endocrine pancreas development [GO:0031018]; extrinsic apoptotic signaling pathway [GO:0097191]; hepatic immune response [GO:0002384]; interleukin-6-mediated signaling pathway [GO:0070102]; monocyte chemotaxis [GO:0002548]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of interleukin-8 production [GO:0032717]; neutrophil mediated immunity [GO:0002446]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to cytokine [GO:0034097]; T-helper 17 cell lineage commitment [GO:0072540]; vascular endothelial growth factor production [GO:0010573]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:P22272}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:28060820}.; SUBCELLULAR LOCATION: [Soluble interleukin-6 receptor subunit alpha]: Secreted {ECO:0000269|PubMed:28060820}.
P08908	reviewed	5HT1A_HUMAN	5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (G-21) (Serotonin receptor 1A)	HTR1A ADRB2RL1 ADRBRL1	Homo sapiens (Human)	422	FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8138923, ECO:0000269|PubMed:8393041}.		adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; behavioral fear response [GO:0001662]; chemical synaptic transmission [GO:0007268]; exploration behavior [GO:0035640]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gamma-aminobutyric acid signaling pathway [GO:0007214]; positive regulation of cell population proliferation [GO:0008284]; regulation of behavior [GO:0050795]; regulation of dopamine metabolic process [GO:0042053]; regulation of hormone secretion [GO:0046883]; regulation of serotonin secretion [GO:0014062]; regulation of vasoconstriction [GO:0019229]; serotonin metabolic process [GO:0042428]; serotonin receptor signaling pathway [GO:0007210]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; receptor-receptor interaction [GO:0090722]; serotonin binding [GO:0051378]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; receptor-receptor interaction [GO:0090722]; serotonin binding [GO:0051378]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; behavioral fear response [GO:0001662]; chemical synaptic transmission [GO:0007268]; exploration behavior [GO:0035640]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gamma-aminobutyric acid signaling pathway [GO:0007214]; positive regulation of cell population proliferation [GO:0008284]; regulation of behavior [GO:0050795]; regulation of dopamine metabolic process [GO:0042053]; regulation of hormone secretion [GO:0046883]; regulation of serotonin secretion [GO:0014062]; regulation of vasoconstriction [GO:0019229]; serotonin metabolic process [GO:0042428]; serotonin receptor signaling pathway [GO:0007210]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}; Multi-pass membrane protein {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}. Cell projection, dendrite {ECO:0000250|UniProtKB:P19327}.
P08910	reviewed	ABHD2_HUMAN	Monoacylglycerol lipase ABHD2 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 2) (Acetylesterase) (EC 3.1.1.6) (Lung alpha/beta hydrolase 2) (Progesterone-sensitive lipase) (EC 3.1.1.79) (Protein PHPS1-2)	ABHD2 LABH2	Homo sapiens (Human)	425	FUNCTION: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester (PubMed:27247428). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity). {ECO:0000250|UniProtKB:Q9QXM0, ECO:0000269|PubMed:26989199, ECO:0000269|PubMed:27247428}.		acrosome reaction [GO:0007340]; acylglycerol catabolic process [GO:0046464]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793]; negative regulation of smooth muscle cell migration [GO:0014912]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; smooth muscle cell migration [GO:0014909]; sperm capacitation [GO:0048240]; steroid hormone mediated signaling pathway [GO:0043401]	acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126]; sperm plasma membrane [GO:0097524]	acetylesterase activity [GO:0008126]; acylglycerol lipase activity [GO:0047372]; hormone binding [GO:0042562]; hormone-sensitive lipase activity [GO:0033878]; nuclear steroid receptor activity [GO:0003707]; triglyceride lipase activity [GO:0004806]	acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126]; sperm plasma membrane [GO:0097524]; acetylesterase activity [GO:0008126]; acylglycerol lipase activity [GO:0047372]; hormone binding [GO:0042562]; hormone-sensitive lipase activity [GO:0033878]; nuclear steroid receptor activity [GO:0003707]; triglyceride lipase activity [GO:0004806]; acrosome reaction [GO:0007340]; acylglycerol catabolic process [GO:0046464]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793]; negative regulation of smooth muscle cell migration [GO:0014912]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; smooth muscle cell migration [GO:0014909]; sperm capacitation [GO:0048240]; steroid hormone mediated signaling pathway [GO:0043401]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000305|PubMed:26989199}; Single-pass type II membrane protein {ECO:0000305}. Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
P08912	reviewed	ACM5_HUMAN	Muscarinic acetylcholine receptor M5	CHRM5	Homo sapiens (Human)	532	FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.		adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; dopamine transport [GO:0015872]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gastric acid secretion [GO:0001696]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]; transmission of nerve impulse [GO:0019226]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; phosphatidylinositol phospholipase C activity [GO:0004435]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; phosphatidylinositol phospholipase C activity [GO:0004435]; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; dopamine transport [GO:0015872]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gastric acid secretion [GO:0001696]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]; transmission of nerve impulse [GO:0019226]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
P08913	reviewed	ADA2A_HUMAN	Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR)	ADRA2A ADRA2R ADRAR	Homo sapiens (Human)	465	FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}.		actin cytoskeleton organization [GO:0030036]; activation of protein kinase activity [GO:0032147]; activation of protein kinase B activity [GO:0032148]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting adrenergic receptor signaling pathway [GO:0071881]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adrenergic receptor signaling pathway [GO:0071875]; cellular response to hormone stimulus [GO:0032870]; DNA replication [GO:0006260]; fear response [GO:0042596]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; intestinal absorption [GO:0050892]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of insulin secretion [GO:0046676]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of norepinephrine secretion [GO:0010700]; negative regulation of uterine smooth muscle contraction [GO:0070473]; phospholipase C-activating adrenergic receptor signaling pathway [GO:0071882]; platelet activation [GO:0030168]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of wound healing [GO:0090303]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; Ras protein signal transduction [GO:0007265]; receptor transactivation [GO:0035624]; regulation of vasoconstriction [GO:0019229]; Rho protein signal transduction [GO:0007266]; thermoception [GO:0050955]; vasodilation [GO:0042311]	axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; dopaminergic synapse [GO:0098691]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]; receptor complex [GO:0043235]	alpha-1B adrenergic receptor binding [GO:0031692]; alpha-2C adrenergic receptor binding [GO:0031696]; alpha2-adrenergic receptor activity [GO:0004938]; epinephrine binding [GO:0051379]; heterotrimeric G-protein binding [GO:0032795]; norepinephrine binding [GO:0051380]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996]	axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; dopaminergic synapse [GO:0098691]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]; receptor complex [GO:0043235]; alpha-1B adrenergic receptor binding [GO:0031692]; alpha-2C adrenergic receptor binding [GO:0031696]; alpha2-adrenergic receptor activity [GO:0004938]; epinephrine binding [GO:0051379]; heterotrimeric G-protein binding [GO:0032795]; norepinephrine binding [GO:0051380]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996]; actin cytoskeleton organization [GO:0030036]; activation of protein kinase activity [GO:0032147]; activation of protein kinase B activity [GO:0032148]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting adrenergic receptor signaling pathway [GO:0071881]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adrenergic receptor signaling pathway [GO:0071875]; cellular response to hormone stimulus [GO:0032870]; DNA replication [GO:0006260]; fear response [GO:0042596]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; intestinal absorption [GO:0050892]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of insulin secretion [GO:0046676]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of norepinephrine secretion [GO:0010700]; negative regulation of uterine smooth muscle contraction [GO:0070473]; phospholipase C-activating adrenergic receptor signaling pathway [GO:0071882]; platelet activation [GO:0030168]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of wound healing [GO:0090303]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; Ras protein signal transduction [GO:0007265]; receptor transactivation [GO:0035624]; regulation of vasoconstriction [GO:0019229]; Rho protein signal transduction [GO:0007266]; thermoception [GO:0050955]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23105096}; Multi-pass membrane protein {ECO:0000269|PubMed:23105096}.
P08922	reviewed	ROS1_HUMAN	Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)	ROS1 MCF3 ROS	Homo sapiens (Human)	2347	FUNCTION: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.		cell differentiation [GO:0030154]; columnar/cuboidal epithelial cell development [GO:0002066]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of TOR signaling [GO:0032006]; spermatogenesis [GO:0007283]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; cell differentiation [GO:0030154]; columnar/cuboidal epithelial cell development [GO:0002066]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of TOR signaling [GO:0032006]; spermatogenesis [GO:0007283]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
P08949	reviewed	NMB_HUMAN	Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]	NMB	Homo sapiens (Human)	121	FUNCTION: Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity). {ECO:0000250|UniProtKB:P01297, ECO:0000250|UniProtKB:Q9CR53, ECO:0000269|PubMed:31601264}.		antiviral innate immune response [GO:0140374]; arachidonic acid secretion [GO:0050482]; cell-cell signaling [GO:0007267]; Leydig cell proliferation [GO:0160024]; negative regulation of hormone secretion [GO:0046888]; negative regulation of interleukin-6 production [GO:0032715]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of hormone secretion [GO:0046887]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of osteoclast proliferation [GO:0090290]; positive regulation of respiratory gaseous exchange [GO:1903942]; positive regulation of testosterone secretion [GO:2000845]; sensory perception of itch [GO:0160025]; signal transduction [GO:0007165]; sneeze reflex [GO:0160023]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005]	hormone activity [GO:0005179]; neuromedin B receptor binding [GO:0031710]; neuropeptide hormone activity [GO:0005184]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005]; hormone activity [GO:0005179]; neuromedin B receptor binding [GO:0031710]; neuropeptide hormone activity [GO:0005184]; antiviral innate immune response [GO:0140374]; arachidonic acid secretion [GO:0050482]; cell-cell signaling [GO:0007267]; Leydig cell proliferation [GO:0160024]; negative regulation of hormone secretion [GO:0046888]; negative regulation of interleukin-6 production [GO:0032715]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of hormone secretion [GO:0046887]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of osteoclast proliferation [GO:0090290]; positive regulation of respiratory gaseous exchange [GO:1903942]; positive regulation of testosterone secretion [GO:2000845]; sensory perception of itch [GO:0160025]; signal transduction [GO:0007165]; sneeze reflex [GO:0160023]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9CR53}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9CR53}. Note=In neurons of the retrotrapezoid nucleus//parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. {ECO:0000250|UniProtKB:Q9CR53}.
P08962	reviewed	CD63_HUMAN	CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Lysosome integral membrane protein 1) (Limp1) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63)	CD63 MLA1 TSPAN30	Homo sapiens (Human)	238	FUNCTION: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:21803846, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}.	MISCELLANEOUS: Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.; MISCELLANEOUS: This antigen is associated with early stages of melanoma tumor progression.	cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; endosome to melanosome transport [GO:0035646]; pigment granule maturation [GO:0048757]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746]	azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; endosome lumen [GO:0031904]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; multivesicular body membrane [GO:0032585]; multivesicular body, internal vesicle [GO:0097487]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]		azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; endosome lumen [GO:0031904]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; multivesicular body membrane [GO:0032585]; multivesicular body, internal vesicle [GO:0097487]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; endosome to melanosome transport [GO:0035646]; pigment granule maturation [GO:0048757]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15351990, ECO:0000269|PubMed:19640571, ECO:0000269|PubMed:23632027}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:19640571, ECO:0000269|PubMed:1993697, ECO:0000269|PubMed:22431521, ECO:0000269|PubMed:23632027}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:10793155, ECO:0000269|PubMed:23632027}; Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body {ECO:0000269|PubMed:21962903}. Melanosome {ECO:0000269|PubMed:21962903}. Secreted, extracellular exosome {ECO:0000269|PubMed:22660413}. Cell surface {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}. Note=Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903). {ECO:0000269|PubMed:10793155, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:7682577}.
P08F94	reviewed	PKHD1_HUMAN	Fibrocystin (Polycystic kidney and hepatic disease 1 protein) (Polyductin) (Tigmin)	PKHD1 FCYT TIGM1	Homo sapiens (Human)	4074	FUNCTION: Promotes ciliogenesis in renal epithelial cells and therefore participates in the tubules formation and/ or ensures the maintenance of the architecture of the lumen of the kidney (By similarity). Has an impact on cellular symmetry by ensuring correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly and by maintaining oriented cell division (OCD) during tubular elongation through planar cell polarity (PCP) pathway (PubMed:20554582). During epithelial cell morphogenesis regulates also cell-cell and cell-matrix adhesion and participates in cell motility (By similarity). Promotes cell-cell contact through the positive regulation of PTK2 kinase activity leading to either positive regulation of epithelial cell proliferation through the HRAS/RAF1 pathways, or negative regulation of apoptosis through the PDK1/AKT1 pathway (By similarity). May act in collecting-duct and biliary differentiation (PubMed:11919560). May participate in the regulation of the cholangiocytes proliferation and the CCN2 production in an CXCL8-dependent manner (PubMed:30898581). {ECO:0000250|UniProtKB:E2RK30, ECO:0000250|UniProtKB:E9PZ36, ECO:0000269|PubMed:11919560, ECO:0000269|PubMed:20554582, ECO:0000269|PubMed:30898581}.		branching morphogenesis of an epithelial tube [GO:0048754]; cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; homeostatic process [GO:0042592]; intracellular calcium ion homeostasis [GO:0006874]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of cell adhesion [GO:0030155]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell-matrix adhesion [GO:0001952]; regulation of centrosome duplication [GO:0010824]; regulation of cholangiocyte proliferation [GO:1904054]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of establishment of planar polarity [GO:0090175]; regulation of TOR signaling [GO:0032006]	9+0 non-motile cilium [GO:0097731]; apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	signaling receptor activity [GO:0038023]	9+0 non-motile cilium [GO:0097731]; apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; signaling receptor activity [GO:0038023]; branching morphogenesis of an epithelial tube [GO:0048754]; cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; homeostatic process [GO:0042592]; intracellular calcium ion homeostasis [GO:0006874]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of cell adhesion [GO:0030155]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell-matrix adhesion [GO:0001952]; regulation of centrosome duplication [GO:0010824]; regulation of cholangiocyte proliferation [GO:1904054]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of establishment of planar polarity [GO:0090175]; regulation of TOR signaling [GO:0032006]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15458427}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:15458427}. Cell projection, cilium {ECO:0000269|PubMed:14978161, ECO:0000269|PubMed:15458427, ECO:0000269|PubMed:17470460}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:14978161}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20554582}. Chromosome, centromere {ECO:0000269|PubMed:20554582}. Apical cell membrane {ECO:0000250|UniProtKB:E9PZ36}. Nucleus {ECO:0000250|UniProtKB:E9PZ36}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:E9PZ36}. Secreted {ECO:0000250|UniProtKB:E9PZ36}. Endoplasmic reticulum {ECO:0000250|UniProtKB:E9PZ36}. Golgi apparatus {ECO:0000250|UniProtKB:E9PZ36}. Note=The intracellular C-terminal fragment (ICD) translocates to the nucleus and is not detected in primary cilia (PubMed:17470460, PubMed:16956880). The extracellular domain (PECD) traffics beyond the mid-Golgi and localizes on exosome like vesicles (ELVs) attached to the primary cilium (By similarity). In the urine, the extracellular domain (PECD) exists as an highly abundant secreted form and a less abundant PECD form that is either tethered to or shed with the C-terminal fragment (PTM) in ELVs (By similarity). The majority of full length PKHD1 protein resides at the endoplasmic reticulum and cannot pass beyond the mid-Golgi apparatus and is not detected in primary cilia (By similarity). The intra-cellular C-terminal fragment of 21-kDa translocates to the nucleus. The extracellular domain traffics beyond the mid-Golgi and localizes on exosome like vesicles (ELVs) attached to the primary cilium (By similarity). {ECO:0000250|UniProtKB:E9PZ36, ECO:0000269|PubMed:16956880, ECO:0000269|PubMed:17470460}.
P09012	reviewed	SNRPA_HUMAN	U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A)	SNRPA	Homo sapiens (Human)	282	FUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs. {ECO:0000269|PubMed:9848648}.		mRNA splicing, via spliceosome [GO:0000398]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619]; U1 snRNP binding [GO:1990446]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619]; U1 snRNP binding [GO:1990446]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus.
P09016	reviewed	HXD4_HUMAN	Homeobox protein Hox-D4 (Homeobox protein HHO.C13) (Homeobox protein Hox-4B) (Homeobox protein Hox-5.1)	HOXD4 HOX4B	Homo sapiens (Human)	255	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; embryonic organ development [GO:0048568]; embryonic skeletal system morphogenesis [GO:0048704]; positive regulation of transcription by RNA polymerase II [GO:0045944]; stem cell differentiation [GO:0048863]	cell junction [GO:0030054]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	cell junction [GO:0030054]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; embryonic organ development [GO:0048568]; embryonic skeletal system morphogenesis [GO:0048704]; positive regulation of transcription by RNA polymerase II [GO:0045944]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Nucleus.
P09017	reviewed	HXC4_HUMAN	Homeobox protein Hox-C4 (Homeobox protein CP19) (Homeobox protein Hox-3E)	HOXC4 HOX3E	Homo sapiens (Human)	264	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; cartilage development [GO:0051216]; embryonic skeletal system morphogenesis [GO:0048704]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; cartilage development [GO:0051216]; embryonic skeletal system morphogenesis [GO:0048704]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus.
P09038	reviewed	FGF2_HUMAN	Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)	FGF2 FGFB	Homo sapiens (Human)	288	FUNCTION: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3964259, PubMed:3732516). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879). {ECO:0000269|PubMed:1721615, ECO:0000269|PubMed:29501879, ECO:0000269|PubMed:3732516, ECO:0000269|PubMed:3964259}.	MISCELLANEOUS: This protein binds heparin more strongly than does aFGF.; MISCELLANEOUS: [Isoform 1]: Starts at an alternative CUG codon.; MISCELLANEOUS: [Isoform 2]: Starts at an alternative CUG codon. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Starts at an alternative CUG codon. {ECO:0000305}.	angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; animal organ morphogenesis [GO:0009887]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to mechanical stimulus [GO:0071260]; cerebellar granule cell precursor proliferation [GO:0021930]; chemotaxis [GO:0006935]; chondroblast differentiation [GO:0060591]; corticotropin hormone secreting cell differentiation [GO:0060128]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic morphogenesis [GO:0048598]; endothelial cell proliferation [GO:0001935]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glial cell differentiation [GO:0010001]; growth factor dependent regulation of skeletal muscle satellite cell proliferation [GO:0014843]; hyaluronan catabolic process [GO:0030214]; inner ear auditory receptor cell differentiation [GO:0042491]; inositol phosphate biosynthetic process [GO:0032958]; lung development [GO:0030324]; lymphatic endothelial cell migration [GO:1904977]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of gene expression [GO:0010629]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of wound healing [GO:0061045]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; organ induction [GO:0001759]; osteoblast differentiation [GO:0001649]; paracrine signaling [GO:0038001]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell division [GO:0051781]; positive regulation of cell fate specification [GO:0042660]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cerebellar granule cell precursor proliferation [GO:0021940]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of inner ear auditory receptor cell differentiation [GO:0045609]; positive regulation of lens fiber cell differentiation [GO:1902748]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuroepithelial cell differentiation [GO:1902913]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; Ras protein signal transduction [GO:0007265]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903587]; regulation of cell cycle [GO:0051726]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000544]; regulation of retinal cell programmed cell death [GO:0046668]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; signal transduction [GO:0007165]; stem cell development [GO:0048864]; stem cell proliferation [GO:0072089]; substantia nigra development [GO:0021762]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; transcription by RNA polymerase II [GO:0006366]; wound healing [GO:0042060]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]	chemoattractant activity [GO:0042056]; chemokine binding [GO:0019956]; cytokine activity [GO:0005125]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; nuclear receptor coactivator activity [GO:0030374]; receptor-receptor interaction [GO:0090722]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; chemoattractant activity [GO:0042056]; chemokine binding [GO:0019956]; cytokine activity [GO:0005125]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; nuclear receptor coactivator activity [GO:0030374]; receptor-receptor interaction [GO:0090722]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; animal organ morphogenesis [GO:0009887]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to mechanical stimulus [GO:0071260]; cerebellar granule cell precursor proliferation [GO:0021930]; chemotaxis [GO:0006935]; chondroblast differentiation [GO:0060591]; corticotropin hormone secreting cell differentiation [GO:0060128]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic morphogenesis [GO:0048598]; endothelial cell proliferation [GO:0001935]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glial cell differentiation [GO:0010001]; growth factor dependent regulation of skeletal muscle satellite cell proliferation [GO:0014843]; hyaluronan catabolic process [GO:0030214]; inner ear auditory receptor cell differentiation [GO:0042491]; inositol phosphate biosynthetic process [GO:0032958]; lung development [GO:0030324]; lymphatic endothelial cell migration [GO:1904977]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of gene expression [GO:0010629]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of wound healing [GO:0061045]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; organ induction [GO:0001759]; osteoblast differentiation [GO:0001649]; paracrine signaling [GO:0038001]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell division [GO:0051781]; positive regulation of cell fate specification [GO:0042660]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cerebellar granule cell precursor proliferation [GO:0021940]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of inner ear auditory receptor cell differentiation [GO:0045609]; positive regulation of lens fiber cell differentiation [GO:1902748]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuroepithelial cell differentiation [GO:1902913]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; Ras protein signal transduction [GO:0007265]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903587]; regulation of cell cycle [GO:0051726]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000544]; regulation of retinal cell programmed cell death [GO:0046668]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; signal transduction [GO:0007165]; stem cell development [GO:0048864]; stem cell proliferation [GO:0072089]; substantia nigra development [GO:0021762]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; transcription by RNA polymerase II [GO:0006366]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20230531}. Nucleus {ECO:0000269|PubMed:22321063}. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063). {ECO:0000269|PubMed:20230531, ECO:0000269|PubMed:22321063}.
P09067	reviewed	HXB5_HUMAN	Homeobox protein Hox-B5 (Homeobox protein HHO.C10) (Homeobox protein Hox-2A) (Homeobox protein Hu-1)	HOXB5 HOX2A	Homo sapiens (Human)	269	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; endothelial cell differentiation [GO:0045446]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; endothelial cell differentiation [GO:0045446]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P09086	reviewed	PO2F2_HUMAN	POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2)	POU2F2 OCT2 OTF2	Homo sapiens (Human)	479	FUNCTION: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874). {ECO:0000250|UniProtKB:Q00196, ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:2328728, ECO:0000269|PubMed:2901913, ECO:0000269|PubMed:2904654, ECO:0000269|PubMed:7859290}.; FUNCTION: [Isoform 5]: Activates the U2 small nuclear RNA (snRNA) promoter. {ECO:0000269|PubMed:1739980}.	MISCELLANEOUS: [Isoform 5]: Incomplete sequence. {ECO:0000305}.	cellular response to virus [GO:0098586]; humoral immune response [GO:0006959]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cellular response to virus [GO:0098586]; humoral immune response [GO:0006959]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus.
P09104	reviewed	ENOG_HUMAN	Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE)	ENO2	Homo sapiens (Human)	434	FUNCTION: Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}.		canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; perikaryon [GO:0043204]; phosphopyruvate hydratase complex [GO:0000015]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]	magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; perikaryon [GO:0043204]; phosphopyruvate hydratase complex [GO:0000015]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]; canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. {ECO:0000250}.
P09110	reviewed	THIK_HUMAN	3-ketoacyl-CoA thiolase, peroxisomal (EC 2.3.1.16) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Acetyl-CoA acyltransferase) (EC 2.3.1.9) (Beta-ketothiolase) (Peroxisomal 3-oxoacyl-CoA thiolase)	ACAA1 ACAA PTHIO	Homo sapiens (Human)	424	FUNCTION: Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (PubMed:2882519, PubMed:11734571). Plays an important role in fatty acid peroxisomal beta-oxidation (PubMed:2882519, PubMed:11734571). Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs (PubMed:2882519, PubMed:11734571). {ECO:0000305|PubMed:11734571, ECO:0000305|PubMed:2882519}.		alpha-linolenic acid metabolic process [GO:0036109]; bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; phenylacetate catabolic process [GO:0010124]; very long-chain fatty acid metabolic process [GO:0000038]	cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; specific granule lumen [GO:0035580]	acetate CoA-transferase activity [GO:0008775]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; palmitoyl-CoA oxidase activity [GO:0016401]	cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; specific granule lumen [GO:0035580]; acetate CoA-transferase activity [GO:0008775]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; palmitoyl-CoA oxidase activity [GO:0016401]; alpha-linolenic acid metabolic process [GO:0036109]; bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; phenylacetate catabolic process [GO:0010124]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:22057399, ECO:0000269|PubMed:25538232}. Note=Transported into peroxisomes following association with PEX7. {ECO:0000269|PubMed:22057399, ECO:0000269|PubMed:25538232}.
P09132	reviewed	SRP19_HUMAN	Signal recognition particle 19 kDa protein (SRP19)	SRP19	Homo sapiens (Human)	144	FUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity). {ECO:0000250|UniProtKB:J9PAS6}.		cotranslational protein targeting to membrane [GO:0006613]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]	7S RNA binding [GO:0008312]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; cotranslational protein targeting to membrane [GO:0006613]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10618370, ECO:0000269|PubMed:11682607}. Nucleus, nucleolus {ECO:0000269|PubMed:10618370, ECO:0000269|PubMed:11682607}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11682607}. Note=Although the signal recognition particle complex acts in the cytoplasm, it assembles at least in part in the nucleus and/or the nucleolus. SRP19 nuclear import may be mediated by IPO8/Imp8 and TPNO1/Trn. {ECO:0000269|PubMed:11682607}.
P09172	reviewed	DOPO_HUMAN	Dopamine beta-hydroxylase (EC 1.14.17.1) (Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase]	DBH	Homo sapiens (Human)	617	FUNCTION: Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters. {ECO:0000269|PubMed:27148966, ECO:0000269|PubMed:3443096, ECO:0000269|PubMed:7961964, ECO:0000269|PubMed:8546710}.		behavioral response to ethanol [GO:0048149]; blood vessel remodeling [GO:0001974]; chemical synaptic transmission [GO:0007268]; dopamine catabolic process [GO:0042420]; fear response [GO:0042596]; glucose homeostasis [GO:0042593]; homoiothermy [GO:0042309]; leukocyte mediated immunity [GO:0002443]; leukocyte migration [GO:0050900]; locomotory behavior [GO:0007626]; maternal behavior [GO:0042711]; memory [GO:0007613]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of vasoconstriction [GO:0045907]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]; regulation of vascular associated smooth muscle cell proliferation [GO:1904705]; regulation of vascular endothelial cell proliferation [GO:1905562]; response to amphetamine [GO:0001975]; response to pain [GO:0048265]; vasoconstriction [GO:0042310]; visual learning [GO:0008542]	centriolar satellite [GO:0034451]; chromaffin granule lumen [GO:0034466]; chromaffin granule membrane [GO:0042584]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658]	catalytic activity [GO:0003824]; copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; L-ascorbic acid binding [GO:0031418]	centriolar satellite [GO:0034451]; chromaffin granule lumen [GO:0034466]; chromaffin granule membrane [GO:0042584]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658]; catalytic activity [GO:0003824]; copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; L-ascorbic acid binding [GO:0031418]; behavioral response to ethanol [GO:0048149]; blood vessel remodeling [GO:0001974]; chemical synaptic transmission [GO:0007268]; dopamine catabolic process [GO:0042420]; fear response [GO:0042596]; glucose homeostasis [GO:0042593]; homoiothermy [GO:0042309]; leukocyte mediated immunity [GO:0002443]; leukocyte migration [GO:0050900]; locomotory behavior [GO:0007626]; maternal behavior [GO:0042711]; memory [GO:0007613]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of vasoconstriction [GO:0045907]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]; regulation of vascular associated smooth muscle cell proliferation [GO:1904705]; regulation of vascular endothelial cell proliferation [GO:1905562]; response to amphetamine [GO:0001975]; response to pain [GO:0048265]; vasoconstriction [GO:0042310]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: [Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000269|PubMed:7961964}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen {ECO:0000269|PubMed:7961964}. Secreted {ECO:0000269|PubMed:7961964, ECO:0000269|PubMed:8546710}.; SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:7961964}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000269|PubMed:7961964}; Single-pass type II membrane protein {ECO:0000305}.
P09210	reviewed	GSTA2_HUMAN	Glutathione S-transferase A2 (EC 2.5.1.18) (GST HA subunit 2) (GST class-alpha member 2) (GST-gamma) (GSTA2-2) (GTH2)	GSTA2 GST2	Homo sapiens (Human)	222	FUNCTION: Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds. {ECO:0000250|UniProtKB:P10648}.		epithelial cell differentiation [GO:0030855]; glutathione metabolic process [GO:0006749]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	glutathione transferase activity [GO:0004364]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutathione transferase activity [GO:0004364]; epithelial cell differentiation [GO:0030855]; glutathione metabolic process [GO:0006749]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm.
P09211	reviewed	GSTP1_HUMAN	Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1)	GSTP1 FAEES3 GST3	Homo sapiens (Human)	210	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}.		cellular response to lipopolysaccharide [GO:0071222]; central nervous system development [GO:0007417]; common myeloid progenitor cell proliferation [GO:0035726]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of biosynthetic process [GO:0009890]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of leukocyte proliferation [GO:0070664]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nitric oxide storage [GO:0035732]; positive regulation of superoxide anion generation [GO:0032930]; prostaglandin metabolic process [GO:0006693]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of stress-activated MAPK cascade [GO:0032872]; response to reactive oxygen species [GO:0000302]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; TRAF2-GSTP1 complex [GO:0097057]; vesicle [GO:0031982]	dinitrosyl-iron complex binding [GO:0035731]; fatty acid binding [GO:0005504]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; JUN kinase binding [GO:0008432]; kinase regulator activity [GO:0019207]; nitric oxide binding [GO:0070026]; S-nitrosoglutathione binding [GO:0035730]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; TRAF2-GSTP1 complex [GO:0097057]; vesicle [GO:0031982]; dinitrosyl-iron complex binding [GO:0035731]; fatty acid binding [GO:0005504]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; JUN kinase binding [GO:0008432]; kinase regulator activity [GO:0019207]; nitric oxide binding [GO:0070026]; S-nitrosoglutathione binding [GO:0035730]; cellular response to lipopolysaccharide [GO:0071222]; central nervous system development [GO:0007417]; common myeloid progenitor cell proliferation [GO:0035726]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of biosynthetic process [GO:0009890]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of leukocyte proliferation [GO:0070664]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nitric oxide storage [GO:0035732]; positive regulation of superoxide anion generation [GO:0032930]; prostaglandin metabolic process [GO:0006693]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of stress-activated MAPK cascade [GO:0032872]; response to reactive oxygen species [GO:0000302]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19269317}. Mitochondrion {ECO:0000269|PubMed:19269317}. Nucleus {ECO:0000269|PubMed:19269317}. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.
P09228	reviewed	CYTT_HUMAN	Cystatin-SA (Cystatin-2) (Cystatin-S5)	CST2	Homo sapiens (Human)	141	FUNCTION: Thiol protease inhibitor.		detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; vesicle [GO:0031982]	cysteine-type endopeptidase inhibitor activity [GO:0004869]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; vesicle [GO:0031982]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20189825}.
P09234	reviewed	RU1C_HUMAN	U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C)	SNRPC	Homo sapiens (Human)	159	FUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:1826349, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2136774, ECO:0000269|PubMed:8798632}.		mRNA 5'-splice site recognition [GO:0000395]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal snRNP assembly [GO:0000387]	Cajal body [GO:0015030]; commitment complex [GO:0000243]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]	mRNA binding [GO:0003729]; pre-mRNA 5'-splice site binding [GO:0030627]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	Cajal body [GO:0015030]; commitment complex [GO:0000243]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]; mRNA binding [GO:0003729]; pre-mRNA 5'-splice site binding [GO:0030627]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]; mRNA 5'-splice site recognition [GO:0000395]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:2136774}.
P09237	reviewed	MMP7_HUMAN	Matrilysin (EC 3.4.24.23) (Matrin) (Matrix metalloproteinase-7) (MMP-7) (Pump-1 protease) (Uterine metalloproteinase)	MMP7 MPSL1 PUMP1	Homo sapiens (Human)	267	FUNCTION: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. {ECO:0000269|PubMed:2550050}.		collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; positive regulation of cell migration [GO:0030335]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; positive regulation of cell migration [GO:0030335]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
P09238	reviewed	MMP10_HUMAN	Stromelysin-2 (SL-2) (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2)	MMP10 STMY2	Homo sapiens (Human)	476	FUNCTION: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.		collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
P09326	reviewed	CD48_HUMAN	CD48 antigen (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (TCT.1) (CD antigen CD48)	CD48 BCM1 BLAST1	Homo sapiens (Human)	243	FUNCTION: Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:27249817, PubMed:12007789). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex (PubMed:19494291). In turn, promotes LCK phosphorylation and subsequent activation (PubMed:12007789). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (PubMed:9841922, PubMed:27249817). {ECO:0000269|PubMed:12007789, ECO:0000269|PubMed:19494291, ECO:0000269|PubMed:27249817, ECO:0000269|PubMed:9841922}.		defense response [GO:0006952]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; defense response [GO:0006952]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1999351, ECO:0000269|PubMed:9041467}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1999351}. Secreted {ECO:0000269|PubMed:9418191}.
P09327	reviewed	VILI_HUMAN	Villin-1	VIL1 VIL	Homo sapiens (Human)	827	FUNCTION: Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. {ECO:0000269|PubMed:11500485, ECO:0000269|PubMed:14594952, ECO:0000269|PubMed:15084600, ECO:0000269|PubMed:15272027, ECO:0000269|PubMed:15342783, ECO:0000269|PubMed:16921170, ECO:0000269|PubMed:17182858, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:17606613, ECO:0000269|PubMed:18054784, ECO:0000269|PubMed:18198174, ECO:0000269|PubMed:19808673, ECO:0000269|PubMed:3087992}.		actin filament capping [GO:0051693]; actin filament depolymerization [GO:0030042]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; apoptotic process [GO:0006915]; barbed-end actin filament capping [GO:0051016]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell differentiation [GO:0030855]; intestinal D-glucose absorption [GO:0001951]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein-containing complex assembly [GO:0065003]; regulation of actin nucleation [GO:0051125]; regulation of cell shape [GO:0008360]; regulation of lamellipodium morphogenesis [GO:2000392]; regulation of microvillus length [GO:0032532]; regulation of wound healing [GO:0061041]; response to bacterium [GO:0009617]; terminal web assembly [GO:1902896]	actin cytoskeleton [GO:0015629]; actin filament bundle [GO:0032432]; brush border [GO:0005903]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; lysophosphatidic acid binding [GO:0035727]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein homodimerization activity [GO:0042803]	actin cytoskeleton [GO:0015629]; actin filament bundle [GO:0032432]; brush border [GO:0005903]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; lysophosphatidic acid binding [GO:0035727]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein homodimerization activity [GO:0042803]; actin filament capping [GO:0051693]; actin filament depolymerization [GO:0030042]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; apoptotic process [GO:0006915]; barbed-end actin filament capping [GO:0051016]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell differentiation [GO:0030855]; intestinal D-glucose absorption [GO:0001951]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein-containing complex assembly [GO:0065003]; regulation of actin nucleation [GO:0051125]; regulation of cell shape [GO:0008360]; regulation of lamellipodium morphogenesis [GO:2000392]; regulation of microvillus length [GO:0032532]; regulation of wound healing [GO:0061041]; response to bacterium [GO:0009617]; terminal web assembly [GO:1902896]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, microvillus. Cell projection, filopodium tip {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Relocalized in the tip of cellular protrusions and filipodial extensions upon infection with S.flexneri in primary intestinal epithelial cells (IEC) and in the tail-like structures forming the actin comets of S.flexneri. Redistributed to the leading edge of hepatocyte growth factor (HGF)-induced lamellipodia (By similarity). Rapidly redistributed to ruffles and lamellipodia structures in response to autotaxin, lysophosphatidic acid (LPA) and epidermal growth factor (EGF) treatment. {ECO:0000250}.
P09341	reviewed	GROA_HUMAN	Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)]	CXCL1 GRO GRO1 GROA MGSA SCYB1	Homo sapiens (Human)	107	FUNCTION: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. {ECO:0000269|PubMed:10095777}.		actin cytoskeleton organization [GO:0030036]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; neutrophil chemotaxis [GO:0030593]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; enzyme activator activity [GO:0008047]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; enzyme activator activity [GO:0008047]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102]; actin cytoskeleton organization [GO:0030036]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; neutrophil chemotaxis [GO:0030593]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P09382	reviewed	LEG1_HUMAN	Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)	LGALS1	Homo sapiens (Human)	135	FUNCTION: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. {ECO:0000269|PubMed:14617626, ECO:0000269|PubMed:18796645, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:24945728}.		apoptotic process [GO:0006915]; cell-cell adhesion [GO:0098609]; myoblast differentiation [GO:0045445]; plasma cell differentiation [GO:0002317]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of inflammatory response [GO:0050729]; positive regulation of viral entry into host cell [GO:0046598]; regulation of apoptotic process [GO:0042981]; T cell costimulation [GO:0031295]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; galectin complex [GO:1990724]	carbohydrate binding [GO:0030246]; laminin binding [GO:0043236]; RNA binding [GO:0003723]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; galectin complex [GO:1990724]; carbohydrate binding [GO:0030246]; laminin binding [GO:0043236]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; cell-cell adhesion [GO:0098609]; myoblast differentiation [GO:0045445]; plasma cell differentiation [GO:0002317]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of inflammatory response [GO:0050729]; positive regulation of viral entry into host cell [GO:0046598]; regulation of apoptotic process [GO:0042981]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:14617626}. Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:32272059}. Note=Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}.
P09417	reviewed	DHPR_HUMAN	Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) (Short chain dehydrogenase/reductase family 33C member 1)	QDPR DHPR SDR33C1	Homo sapiens (Human)	244	FUNCTION: Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin. {ECO:0000269|PubMed:3033643, ECO:0000269|PubMed:8262916}.		amino acid metabolic process [GO:0006520]; dihydrobiopterin metabolic process [GO:0051066]; L-phenylalanine catabolic process [GO:0006559]; tetrahydrobiopterin biosynthetic process [GO:0006729]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	6,7-dihydropteridine reductase activity [GO:0004155]; electron transfer activity [GO:0009055]; NADH binding [GO:0070404]; NADPH binding [GO:0070402]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 6,7-dihydropteridine reductase activity [GO:0004155]; electron transfer activity [GO:0009055]; NADH binding [GO:0070404]; NADPH binding [GO:0070402]; amino acid metabolic process [GO:0006520]; dihydrobiopterin metabolic process [GO:0051066]; L-phenylalanine catabolic process [GO:0006559]; tetrahydrobiopterin biosynthetic process [GO:0006729]	
P09429	reviewed	HMGB1_HUMAN	High mobility group protein B1 (High mobility group protein 1) (HMG-1)	HMGB1 HMG1	Homo sapiens (Human)	215	FUNCTION: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19446504, PubMed:19360789). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}.	MISCELLANEOUS: Proposed to contribute to the pathogenesis of various chronic inflammatory and autoimmune diseases, and cancer. High serum levels are found in several inflammatory events including sepsis, rheumatoid arthritis, artherosclerosis chronic kidney disease, systemic lupus erythematosus (SLE). Seems to be implicated in other diseases characterized by cell death and damage, including diabetes and Alzheimer's disease. Its nucleosome-associated release during secondary necrosis may play a role in SLE (PubMed:19064698). During chemotherapy can mediate regrowth and metastasis of remaining cells in a AGER/RAGE-dependent manner (PubMed:23040637). Purified HMG box 1 acts as a specific antagonist to HGMB1 pro-inflammatory activities (PubMed:14695889). {ECO:0000269|PubMed:14695889, ECO:0000269|PubMed:23040637, ECO:0000305, ECO:0000305|PubMed:19064698, ECO:0000305|PubMed:24220159, ECO:0000305|PubMed:26078984}.	activation of innate immune response [GO:0002218]; apoptotic cell clearance [GO:0043277]; autophagy [GO:0006914]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell chemotaxis [GO:0002407]; DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; DNA topological change [GO:0006265]; double-strand break repair via nonhomologous end joining [GO:0006303]; heterochromatin formation [GO:0031507]; inflammatory response [GO:0006954]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; myeloid dendritic cell activation [GO:0001773]; negative regulation of apoptotic cell clearance [GO:2000426]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0017055]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; neuron projection development [GO:0031175]; neutrophil clearance [GO:0097350]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA ligation [GO:0051106]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mismatch repair [GO:0032425]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; positive regulation of viral entry into host cell [GO:0046598]; regulation of restriction endodeoxyribonuclease activity [GO:0032072]; regulation of T cell mediated immune response to tumor cell [GO:0002840]; regulation of tolerance induction [GO:0002643]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 1 cell activation [GO:0035711]; T-helper 1 cell differentiation [GO:0045063]; V(D)J recombination [GO:0033151]	alphav-beta3 integrin-HMGB1 complex [GO:0035868]; cell surface [GO:0009986]; condensed chromosome [GO:0000793]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; transcription repressor complex [GO:0017053]	bubble DNA binding [GO:0000405]; C-X-C chemokine binding [GO:0019958]; chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; damaged DNA binding [GO:0003684]; DNA binding, bending [GO:0008301]; DNA polymerase binding [GO:0070182]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; integrin binding [GO:0005178]; lipopolysaccharide binding [GO:0001530]; lyase activity [GO:0016829]; phosphatidylserine binding [GO:0001786]; RAGE receptor binding [GO:0050786]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	alphav-beta3 integrin-HMGB1 complex [GO:0035868]; cell surface [GO:0009986]; condensed chromosome [GO:0000793]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; transcription repressor complex [GO:0017053]; bubble DNA binding [GO:0000405]; C-X-C chemokine binding [GO:0019958]; chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; damaged DNA binding [GO:0003684]; DNA binding, bending [GO:0008301]; DNA polymerase binding [GO:0070182]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; integrin binding [GO:0005178]; lipopolysaccharide binding [GO:0001530]; lyase activity [GO:0016829]; phosphatidylserine binding [GO:0001786]; RAGE receptor binding [GO:0050786]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; activation of innate immune response [GO:0002218]; apoptotic cell clearance [GO:0043277]; autophagy [GO:0006914]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell chemotaxis [GO:0002407]; DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; DNA topological change [GO:0006265]; double-strand break repair via nonhomologous end joining [GO:0006303]; heterochromatin formation [GO:0031507]; inflammatory response [GO:0006954]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; myeloid dendritic cell activation [GO:0001773]; negative regulation of apoptotic cell clearance [GO:2000426]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0017055]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; neuron projection development [GO:0031175]; neutrophil clearance [GO:0097350]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA ligation [GO:0051106]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mismatch repair [GO:0032425]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; positive regulation of viral entry into host cell [GO:0046598]; regulation of restriction endodeoxyribonuclease activity [GO:0032072]; regulation of T cell mediated immune response to tumor cell [GO:0002840]; regulation of tolerance induction [GO:0002643]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 1 cell activation [GO:0035711]; T-helper 1 cell differentiation [GO:0045063]; V(D)J recombination [GO:0033151]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12231511, ECO:0000269|PubMed:17114460, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:22696656, ECO:0000269|PubMed:22869893, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:33147444}. Chromosome {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63159, ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:11154118, ECO:0000269|PubMed:12231511, ECO:0000269|PubMed:17114460, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:22869893, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34971702}. Secreted {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:12231511, ECO:0000269|PubMed:14532127, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:19811284, ECO:0000269|PubMed:22869893, ECO:0000269|PubMed:33147444}. Cell membrane {ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:11154118}; Peripheral membrane protein {ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:11154118}; Extracellular side {ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:11154118}. Endosome {ECO:0000250|UniProtKB:P63158}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:P63158}. Note=In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460). Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940). Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity). Passively released to the extracellular milieu from necrotic cells by diffusion, involving the fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284). Also released from apoptotic cells (PubMed:16855214, PubMed:18631454). Active secretion from a variety of immune and non-immune cells such as macrophages, monocytes, neutrophils, dendritic cells and natural killer cells in response to various stimuli such as LPS and cytokines involves a nonconventional secretory process via secretory lysosomes (PubMed:12231511, PubMed:14532127, PubMed:15944249). Secreted by plasma cells in response to LPS (By similarity). Found on the surface of activated platelets (PubMed:11154118). An increased chromatin association is observed when associated with the adenovirus protein pVII (PubMed:27362237). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:11154118, ECO:0000269|PubMed:12231511, ECO:0000269|PubMed:14532127, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:16855214, ECO:0000269|PubMed:17114460, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19811284, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:27362237, ECO:0000305|PubMed:20123072}.; SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:35239449}. Note=(Microbial infection) SARS-COV-2 ORF3A promotes HMGB1 translocation from the nucleus to the cytoplasm where it is recruited by and colocalizes with ORF3A at the endoplasmic reticulum. {ECO:0000269|PubMed:35239449}.
P09430	reviewed	STP1_HUMAN	Spermatid nuclear transition protein 1 (STP-1) (TP-1)	TNP1	Homo sapiens (Human)	55	FUNCTION: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. {ECO:0000250|UniProtKB:P10856}.		chromatin remodeling [GO:0006338]; flagellated sperm motility [GO:0030317]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome disassembly [GO:0006337]; positive regulation of protein processing [GO:0010954]; sexual reproduction [GO:0019953]; single strand break repair [GO:0000012]; sperm DNA condensation [GO:0035092]; sperm DNA decondensation [GO:0035041]; spermatid development [GO:0007286]; spermatid nucleus differentiation [GO:0007289]; spermatid nucleus elongation [GO:0007290]	male germ cell nucleus [GO:0001673]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]	male germ cell nucleus [GO:0001673]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; chromatin remodeling [GO:0006338]; flagellated sperm motility [GO:0030317]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome disassembly [GO:0006337]; positive regulation of protein processing [GO:0010954]; sexual reproduction [GO:0019953]; single strand break repair [GO:0000012]; sperm DNA condensation [GO:0035092]; sperm DNA decondensation [GO:0035041]; spermatid development [GO:0007286]; spermatid nucleus differentiation [GO:0007289]; spermatid nucleus elongation [GO:0007290]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10856}. Chromosome {ECO:0000250|UniProtKB:P10856}. Note=Loaded onto the nucleosomes of condensing spermatids. {ECO:0000250|UniProtKB:P10856}.
P09455	reviewed	RET1_HUMAN	Retinol-binding protein 1 (Cellular retinol-binding protein) (CRBP) (Cellular retinol-binding protein I) (CRBP-I)	RBP1 CRBP1	Homo sapiens (Human)	135	FUNCTION: Cytoplasmic retinol-binding protein (PubMed:22665496, PubMed:26900151, PubMed:28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed:15632377, PubMed:22665496). {ECO:0000269|PubMed:15632377, ECO:0000269|PubMed:22665496, ECO:0000269|PubMed:26900151, ECO:0000269|PubMed:28057518}.		fatty acid transport [GO:0015908]; lipid homeostasis [GO:0055088]; retinoic acid biosynthetic process [GO:0002138]; vitamin A metabolic process [GO:0006776]	cytosol [GO:0005829]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	all-trans-retinol binding [GO:1904768]; fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoid binding [GO:0005501]	cytosol [GO:0005829]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; all-trans-retinol binding [GO:1904768]; fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoid binding [GO:0005501]; fatty acid transport [GO:0015908]; lipid homeostasis [GO:0055088]; retinoic acid biosynthetic process [GO:0002138]; vitamin A metabolic process [GO:0006776]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:22665496}. Lipid droplet {ECO:0000269|PubMed:15632377}.
P09466	reviewed	PAEP_HUMAN	Glycodelin (GD) (Placental protein 14) (PP14) (Pregnancy-associated endometrial alpha-2 globulin) (PAEG) (PEG) (Progestagen-associated endometrial protein) (Progesterone-associated endometrial protein) (Zona-binding inhibitory factor-1) (ZIF-1)	PAEP	Homo sapiens (Human)	180	FUNCTION: Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155). {ECO:0000269|PubMed:12672671, ECO:0000269|PubMed:15883155, ECO:0000269|PubMed:17192260, ECO:0000269|PubMed:7531163, ECO:0000269|PubMed:9918684}.		apoptotic process [GO:0006915]; negative regulation of sperm capacitation [GO:1902491]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; regulation of binding of sperm to zona pellucida [GO:2000359]	extracellular region [GO:0005576]	small molecule binding [GO:0036094]	extracellular region [GO:0005576]; small molecule binding [GO:0036094]; apoptotic process [GO:0006915]; negative regulation of sperm capacitation [GO:1902491]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; regulation of binding of sperm to zona pellucida [GO:2000359]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12672671, ECO:0000269|PubMed:17192260, ECO:0000269|PubMed:3667877}.
P09467	reviewed	F16P1_HUMAN	Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase)	FBP1 FBP	Homo sapiens (Human)	338	FUNCTION: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}.		cellular hyperosmotic salinity response [GO:0071475]; cellular hypotonic salinity response [GO:0071477]; cellular response to cAMP [GO:0071320]; cellular response to insulin stimulus [GO:0032869]; cellular response to magnesium ion [GO:0071286]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to raffinose [GO:0097403]; cellular response to xenobiotic stimulus [GO:0071466]; dephosphorylation [GO:0016311]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; negative regulation of cell growth [GO:0030308]; negative regulation of glycolytic process [GO:0045820]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gluconeogenesis [GO:0006111]; response to nutrient levels [GO:0031667]; sucrose biosynthetic process [GO:0005986]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	AMP binding [GO:0016208]; fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; AMP binding [GO:0016208]; fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; cellular hyperosmotic salinity response [GO:0071475]; cellular hypotonic salinity response [GO:0071477]; cellular response to cAMP [GO:0071320]; cellular response to insulin stimulus [GO:0032869]; cellular response to magnesium ion [GO:0071286]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to raffinose [GO:0097403]; cellular response to xenobiotic stimulus [GO:0071466]; dephosphorylation [GO:0016311]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; negative regulation of cell growth [GO:0030308]; negative regulation of glycolytic process [GO:0045820]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gluconeogenesis [GO:0006111]; response to nutrient levels [GO:0031667]; sucrose biosynthetic process [GO:0005986]	
P09471	reviewed	GNAO_HUMAN	Guanine nucleotide-binding protein G(o) subunit alpha	GNAO1	Homo sapiens (Human)	354	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; dopamine receptor signaling pathway [GO:0007212]; muscle contraction [GO:0006936]	heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]	corticotropin-releasing hormone receptor 1 binding [GO:0051430]; G protein-coupled serotonin receptor binding [GO:0031821]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; mu-type opioid receptor binding [GO:0031852]	heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; corticotropin-releasing hormone receptor 1 binding [GO:0051430]; G protein-coupled serotonin receptor binding [GO:0031821]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; mu-type opioid receptor binding [GO:0031852]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; dopamine receptor signaling pathway [GO:0007212]; muscle contraction [GO:0006936]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:34685729}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
P09486	reviewed	SPRC_HUMAN	SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine)	SPARC ON	Homo sapiens (Human)	303	FUNCTION: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.		anatomical structure development [GO:0048856]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of endothelial cell migration [GO:0010595]; regulation of cell morphogenesis [GO:0022604]	basement membrane [GO:0005604]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endocytic vesicle lumen [GO:0071682]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; platelet alpha granule membrane [GO:0031092]	calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]	basement membrane [GO:0005604]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endocytic vesicle lumen [GO:0071682]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; platelet alpha granule membrane [GO:0031092]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; anatomical structure development [GO:0048856]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of endothelial cell migration [GO:0010595]; regulation of cell morphogenesis [GO:0022604]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2306517, ECO:0000269|PubMed:3400777, ECO:0000269|PubMed:7495300, ECO:0000269|PubMed:9457905}. Note=In or around the basement membrane.
P09488	reviewed	GSTM1_HUMAN	Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST HB subunit 4) (GST class-mu 1) (GSTM1-1) (GSTM1a-1a) (GSTM1b-1b) (GTH4)	GSTM1 GST1	Homo sapiens (Human)	218	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). {ECO:0000269|PubMed:16548513, ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:9084911}.		cellular detoxification of nitrogen compound [GO:0070458]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; hepoxilin biosynthetic process [GO:0051122]; nitrobenzene metabolic process [GO:0018916]; prostaglandin metabolic process [GO:0006693]; xenobiotic catabolic process [GO:0042178]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]	enzyme binding [GO:0019899]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; enzyme binding [GO:0019899]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; protein homodimerization activity [GO:0042803]; cellular detoxification of nitrogen compound [GO:0070458]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; hepoxilin biosynthetic process [GO:0051122]; nitrobenzene metabolic process [GO:0018916]; prostaglandin metabolic process [GO:0006693]; xenobiotic catabolic process [GO:0042178]	SUBCELLULAR LOCATION: Cytoplasm.
P09493	reviewed	TPM1_HUMAN	Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)	TPM1 C15orf13 TMSA	Homo sapiens (Human)	284	FUNCTION: Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.	MISCELLANEOUS: [Isoform 2]: Incomplete sequence. {ECO:0000305}.	actin filament organization [GO:0007015]; cardiac muscle contraction [GO:0060048]; cellular response to reactive oxygen species [GO:0034614]; cytoskeleton organization [GO:0007010]; muscle filament sliding [GO:0030049]; negative regulation of cell migration [GO:0030336]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of cell adhesion [GO:0045785]; positive regulation of heart rate by epinephrine [GO:0003065]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell shape [GO:0008360]; regulation of heart contraction [GO:0008016]; regulation of muscle contraction [GO:0006937]; ruffle organization [GO:0031529]; sarcomere organization [GO:0045214]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; wound healing [GO:0042060]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; bleb [GO:0032059]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; muscle thin filament tropomyosin [GO:0005862]; ruffle membrane [GO:0032587]; sarcomere [GO:0030017]; stress fiber [GO:0001725]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; bleb [GO:0032059]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; muscle thin filament tropomyosin [GO:0005862]; ruffle membrane [GO:0032587]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; actin filament organization [GO:0007015]; cardiac muscle contraction [GO:0060048]; cellular response to reactive oxygen species [GO:0034614]; cytoskeleton organization [GO:0007010]; muscle filament sliding [GO:0030049]; negative regulation of cell migration [GO:0030336]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of cell adhesion [GO:0045785]; positive regulation of heart rate by epinephrine [GO:0003065]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell shape [GO:0008360]; regulation of heart contraction [GO:0008016]; regulation of muscle contraction [GO:0006937]; ruffle organization [GO:0031529]; sarcomere organization [GO:0045214]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P04692}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P04692}.
P09496	reviewed	CLCA_HUMAN	Clathrin light chain A (Lca)	CLTA	Homo sapiens (Human)	248	FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582). {ECO:0000305|PubMed:15858577, ECO:0000305|PubMed:21297582}.		cell cycle [GO:0007049]; cell division [GO:0051301]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]	clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin vesicle coat [GO:0030125]; clathrin-coated endocytic vesicle [GO:0045334]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic endocytic zone cytoplasmic component [GO:0099631]; presynaptic endocytic zone membrane [GO:0098835]; spindle [GO:0005819]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network membrane [GO:0032588]	clathrin heavy chain binding [GO:0032050]; GTPase binding [GO:0051020]; peptide binding [GO:0042277]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]	clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin vesicle coat [GO:0030125]; clathrin-coated endocytic vesicle [GO:0045334]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic endocytic zone cytoplasmic component [GO:0099631]; presynaptic endocytic zone membrane [GO:0098835]; spindle [GO:0005819]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network membrane [GO:0032588]; clathrin heavy chain binding [GO:0032050]; GTPase binding [GO:0051020]; peptide binding [GO:0042277]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]; cell cycle [GO:0007049]; cell division [GO:0051301]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:21297582, ECO:0000305|PubMed:15858577}. Note=Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles. {ECO:0000305}.
P09497	reviewed	CLCB_HUMAN	Clathrin light chain B (Lcb)	CLTB	Homo sapiens (Human)	229	FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.		clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]	ciliary membrane [GO:0060170]; clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin vesicle coat [GO:0030125]; clathrin-coated endocytic vesicle [GO:0045334]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; postsynaptic endocytic zone cytoplasmic component [GO:0099631]; presynaptic endocytic zone membrane [GO:0098835]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]	clathrin heavy chain binding [GO:0032050]; peptide binding [GO:0042277]; structural molecule activity [GO:0005198]	ciliary membrane [GO:0060170]; clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin vesicle coat [GO:0030125]; clathrin-coated endocytic vesicle [GO:0045334]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; postsynaptic endocytic zone cytoplasmic component [GO:0099631]; presynaptic endocytic zone membrane [GO:0098835]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; clathrin heavy chain binding [GO:0032050]; peptide binding [GO:0042277]; structural molecule activity [GO:0005198]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
P09525	reviewed	ANXA4_HUMAN	Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II)	ANXA4 ANX4	Homo sapiens (Human)	319	FUNCTION: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. {ECO:0000250}.	MISCELLANEOUS: Seems to bind one calcium ion with high affinity.	epithelial cell differentiation [GO:0030855]; negative regulation of apoptotic process [GO:0043066]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; Notch signaling pathway [GO:0007219]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; phospholipase inhibitor activity [GO:0004859]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; phospholipase inhibitor activity [GO:0004859]; epithelial cell differentiation [GO:0030855]; negative regulation of apoptotic process [GO:0043066]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; Notch signaling pathway [GO:0007219]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Zymogen granule membrane {ECO:0000250|UniProtKB:P50994}; Peripheral membrane protein {ECO:0000250|UniProtKB:P50994}.
P09529	reviewed	INHBB_HUMAN	Inhibin beta B chain (Activin beta-B chain)	INHBB	Homo sapiens (Human)	407	FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.		activin receptor signaling pathway [GO:0032924]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to cholesterol [GO:0071397]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-1 [GO:0071347]; cellular response to leptin stimulus [GO:0044320]; cellular response to starvation [GO:0009267]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; cellular response to thyroid hormone stimulus [GO:0097067]; defense response [GO:0006952]; fat cell differentiation [GO:0045444]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of hepatocyte growth factor production [GO:0032686]; negative regulation of insulin secretion [GO:0046676]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; pituitary gland development [GO:0021983]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of ovulation [GO:0060279]; response to gonadotropin [GO:0034698]; response to insecticide [GO:0017085]; response to wounding [GO:0009611]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283]	cell periphery [GO:0071944]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; host cell surface receptor binding [GO:0046789]; protein homodimerization activity [GO:0042803]	cell periphery [GO:0071944]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; host cell surface receptor binding [GO:0046789]; protein homodimerization activity [GO:0042803]; activin receptor signaling pathway [GO:0032924]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to cholesterol [GO:0071397]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-1 [GO:0071347]; cellular response to leptin stimulus [GO:0044320]; cellular response to starvation [GO:0009267]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; cellular response to thyroid hormone stimulus [GO:0097067]; defense response [GO:0006952]; fat cell differentiation [GO:0045444]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of hepatocyte growth factor production [GO:0032686]; negative regulation of insulin secretion [GO:0046676]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; pituitary gland development [GO:0021983]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of ovulation [GO:0060279]; response to gonadotropin [GO:0034698]; response to insecticide [GO:0017085]; response to wounding [GO:0009611]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Secreted.
P09543	reviewed	CN37_HUMAN	2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)	CNP	Homo sapiens (Human)	421	FUNCTION: Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates (By similarity). May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity). {ECO:0000250|UniProtKB:P06623, ECO:0000250|UniProtKB:P16330}.		adult locomotory behavior [GO:0008344]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; cyclic nucleotide catabolic process [GO:0009214]; forebrain development [GO:0030900]; oligodendrocyte differentiation [GO:0048709]; regulation of mitochondrial membrane permeability [GO:0046902]; response to lipopolysaccharide [GO:0032496]; response to toxic substance [GO:0009636]; substantia nigra development [GO:0021762]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; membrane [GO:0016020]; microtubule [GO:0005874]; microvillus [GO:0005902]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; myelin sheath abaxonal region [GO:0035748]; myelin sheath adaxonal region [GO:0035749]; perinuclear region of cytoplasm [GO:0048471]; pseudopodium [GO:0031143]; synapse [GO:0045202]	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [GO:0004113]; cyclic nucleotide binding [GO:0030551]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; membrane [GO:0016020]; microtubule [GO:0005874]; microvillus [GO:0005902]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; myelin sheath abaxonal region [GO:0035748]; myelin sheath adaxonal region [GO:0035749]; perinuclear region of cytoplasm [GO:0048471]; pseudopodium [GO:0031143]; synapse [GO:0045202]; 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [GO:0004113]; cyclic nucleotide binding [GO:0030551]; RNA binding [GO:0003723]; adult locomotory behavior [GO:0008344]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; cyclic nucleotide catabolic process [GO:0009214]; forebrain development [GO:0030900]; oligodendrocyte differentiation [GO:0048709]; regulation of mitochondrial membrane permeability [GO:0046902]; response to lipopolysaccharide [GO:0032496]; response to toxic substance [GO:0009636]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P16330}; Lipid-anchor {ECO:0000250|UniProtKB:P16330}. Melanosome {ECO:0000269|PubMed:12643545}. Note=Firmly bound to membrane structures of brain white matter. {ECO:0000250|UniProtKB:P16330}.
P09544	reviewed	WNT2_HUMAN	Protein Wnt-2 (Int-1-like protein 1) (Int-1-related protein) (IRP)	WNT2 INT1L1 IRP	Homo sapiens (Human)	360	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). {ECO:0000250|UniProtKB:P21552, ECO:0000269|PubMed:20018874}.		atrial cardiac muscle tissue morphogenesis [GO:0055009]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell proliferation [GO:0060038]; cell fate commitment [GO:0045165]; cell proliferation in midbrain [GO:0033278]; cell-cell signaling [GO:0007267]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; iris morphogenesis [GO:0061072]; labyrinthine layer blood vessel development [GO:0060716]; lens development in camera-type eye [GO:0002088]; lung induction [GO:0060492]; mammary gland epithelium development [GO:0061180]; mesenchymal cell proliferation [GO:0010463]; midbrain dopaminergic neuron differentiation [GO:1904948]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription by RNA polymerase II [GO:0045944]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Wnt signalosome [GO:1990909]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Wnt signalosome [GO:1990909]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell proliferation [GO:0060038]; cell fate commitment [GO:0045165]; cell proliferation in midbrain [GO:0033278]; cell-cell signaling [GO:0007267]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; iris morphogenesis [GO:0061072]; labyrinthine layer blood vessel development [GO:0060716]; lens development in camera-type eye [GO:0002088]; lung induction [GO:0060492]; mammary gland epithelium development [GO:0061180]; mesenchymal cell proliferation [GO:0010463]; midbrain dopaminergic neuron differentiation [GO:1904948]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:20018874}.
P09564	reviewed	CD7_HUMAN	T-cell antigen CD7 (GP40) (T-cell leukemia antigen) (T-cell surface antigen Leu-9) (TP41) (CD antigen CD7)	CD7	Homo sapiens (Human)	240	FUNCTION: Not yet known.		adaptive immune response [GO:0002250]; immune response [GO:0006955]; T cell activation [GO:0042110]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	membrane [GO:0016020]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; T cell activation [GO:0042110]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P09601	reviewed	HMOX1_HUMAN	Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form]	HMOX1 HO HO1	Homo sapiens (Human)	288	FUNCTION: [Heme oxygenase 1]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:7703255, PubMed:11121422, PubMed:19556236). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707). {ECO:0000269|PubMed:11121422, ECO:0000269|PubMed:19556236, ECO:0000269|PubMed:7703255, ECO:0000303|PubMed:20055707}.; FUNCTION: [Heme oxygenase 1]: (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy. {ECO:0000269|PubMed:35239449}.; FUNCTION: [Heme oxygenase 1 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:7703255}.		angiogenesis [GO:0001525]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to cadmium ion [GO:0071276]; cellular response to cisplatin [GO:0072719]; cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; endothelial cell proliferation [GO:0001935]; epithelial cell apoptotic process [GO:1904019]; erythrocyte homeostasis [GO:0034101]; heme catabolic process [GO:0042167]; heme oxidation [GO:0006788]; intracellular iron ion homeostasis [GO:0006879]; intracellular signal transduction [GO:0035556]; low-density lipoprotein particle clearance [GO:0034383]; macroautophagy [GO:0016236]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of macroautophagy [GO:0016242]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of chemokine production [GO:0032722]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of macroautophagy [GO:0016239]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of angiogenesis [GO:0045765]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of transcription from RNA polymerase II promoter in response to iron [GO:0034395]; regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619]; response to hydrogen peroxide [GO:0042542]; response to nicotine [GO:0035094]; response to oxidative stress [GO:0006979]; smooth muscle hyperplasia [GO:0014806]; wound healing involved in inflammatory response [GO:0002246]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	enzyme binding [GO:0019899]; heme binding [GO:0020037]; heme oxygenase (decyclizing) activity [GO:0004392]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; heme oxygenase (decyclizing) activity [GO:0004392]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198]; angiogenesis [GO:0001525]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to cadmium ion [GO:0071276]; cellular response to cisplatin [GO:0072719]; cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; endothelial cell proliferation [GO:0001935]; epithelial cell apoptotic process [GO:1904019]; erythrocyte homeostasis [GO:0034101]; heme catabolic process [GO:0042167]; heme oxidation [GO:0006788]; intracellular iron ion homeostasis [GO:0006879]; intracellular signal transduction [GO:0035556]; low-density lipoprotein particle clearance [GO:0034383]; macroautophagy [GO:0016236]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of macroautophagy [GO:0016242]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of chemokine production [GO:0032722]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of macroautophagy [GO:0016239]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of angiogenesis [GO:0045765]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of transcription from RNA polymerase II promoter in response to iron [GO:0034395]; regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619]; response to hydrogen peroxide [GO:0042542]; response to nicotine [GO:0035094]; response to oxidative stress [GO:0006979]; smooth muscle hyperplasia [GO:0014806]; wound healing involved in inflammatory response [GO:0002246]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19556236, ECO:0000269|PubMed:22419571, ECO:0000269|PubMed:27184847}; Single-pass type IV membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000269|PubMed:22419571}.
P09603	reviewed	CSF1_HUMAN	Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) (Proteoglycan macrophage colony-stimulating factor) (PG-M-CSF) [Cleaved into: Processed macrophage colony-stimulating factor 1; Macrophage colony-stimulating factor 1 43 kDa subunit]	CSF1	Homo sapiens (Human)	554	FUNCTION: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061, ECO:0000269|PubMed:8051056}.		branching involved in mammary gland duct morphogenesis [GO:0060444]; developmental process involved in reproduction [GO:0003006]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage colony-stimulating factor signaling pathway [GO:0038145]; macrophage differentiation [GO:0030225]; macrophage homeostasis [GO:0061519]; mammary duct terminal end bud growth [GO:0060763]; mammary gland fat development [GO:0060611]; microglial cell proliferation [GO:0061518]; monocyte activation [GO:0042117]; monocyte differentiation [GO:0030224]; monocyte homeostasis [GO:0035702]; myeloid leukocyte migration [GO:0097529]; neutrophil homeostasis [GO:0001780]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage colony-stimulating factor signaling pathway [GO:1902228]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of macrophage migration [GO:1905523]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of mononuclear cell proliferation [GO:0032946]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of odontogenesis of dentin-containing tooth [GO:0042488]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]; regulation of macrophage derived foam cell differentiation [GO:0010743]; regulation of ossification [GO:0030278]; response to ischemia [GO:0002931]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	CSF1-CSF1R complex [GO:1990682]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; macrophage colony-stimulating factor receptor binding [GO:0005157]; protein homodimerization activity [GO:0042803]	CSF1-CSF1R complex [GO:1990682]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; macrophage colony-stimulating factor receptor binding [GO:0005157]; protein homodimerization activity [GO:0042803]; branching involved in mammary gland duct morphogenesis [GO:0060444]; developmental process involved in reproduction [GO:0003006]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage colony-stimulating factor signaling pathway [GO:0038145]; macrophage differentiation [GO:0030225]; macrophage homeostasis [GO:0061519]; mammary duct terminal end bud growth [GO:0060763]; mammary gland fat development [GO:0060611]; microglial cell proliferation [GO:0061518]; monocyte activation [GO:0042117]; monocyte differentiation [GO:0030224]; monocyte homeostasis [GO:0035702]; myeloid leukocyte migration [GO:0097529]; neutrophil homeostasis [GO:0001780]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage colony-stimulating factor signaling pathway [GO:1902228]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of macrophage migration [GO:1905523]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of mononuclear cell proliferation [GO:0032946]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of odontogenesis of dentin-containing tooth [GO:0042488]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]; regulation of macrophage derived foam cell differentiation [GO:0010743]; regulation of ossification [GO:0030278]; response to ischemia [GO:0002931]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}; Single-pass type I membrane protein {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}.; SUBCELLULAR LOCATION: [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.
P09619	reviewed	PGFRB_HUMAN	Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)	PDGFRB PDGFR PDGFR1	Homo sapiens (Human)	1106	FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164, ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858, ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854, ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772, ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273, ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:8195171}.		aorta morphogenesis [GO:0035909]; cardiac myofibril assembly [GO:0055003]; cell chemotaxis [GO:0060326]; cell migration involved in coronary angiogenesis [GO:0060981]; cell migration involved in vasculogenesis [GO:0035441]; metanephric glomerular capillary formation [GO:0072277]; metanephric glomerular mesangial cell proliferation involved in metanephros development [GO:0072262]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol metabolic process [GO:0046488]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of calcium ion import [GO:0090280]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of chemotaxis [GO:0050921]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; smooth muscle cell chemotaxis [GO:0071670]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; platelet activating factor receptor activity [GO:0004992]; platelet-derived growth factor beta-receptor activity [GO:0005019]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor activity [GO:0005017]; platelet-derived growth factor receptor binding [GO:0005161]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; vascular endothelial growth factor binding [GO:0038085]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; platelet activating factor receptor activity [GO:0004992]; platelet-derived growth factor beta-receptor activity [GO:0005019]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor activity [GO:0005017]; platelet-derived growth factor receptor binding [GO:0005161]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; vascular endothelial growth factor binding [GO:0038085]; aorta morphogenesis [GO:0035909]; cardiac myofibril assembly [GO:0055003]; cell chemotaxis [GO:0060326]; cell migration involved in coronary angiogenesis [GO:0060981]; cell migration involved in vasculogenesis [GO:0035441]; metanephric glomerular capillary formation [GO:0072277]; metanephric glomerular mesangial cell proliferation involved in metanephros development [GO:0072262]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol metabolic process [GO:0046488]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of calcium ion import [GO:0090280]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of chemotaxis [GO:0050921]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; smooth muscle cell chemotaxis [GO:0071670]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
P09622	reviewed	DLDH_HUMAN	Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)	DLD GCSL LAD PHE3	Homo sapiens (Human)	509	FUNCTION: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). {ECO:0000250|UniProtKB:Q811C4, ECO:0000269|PubMed:15712224, ECO:0000269|PubMed:16442803, ECO:0000269|PubMed:16770810, ECO:0000269|PubMed:17404228, ECO:0000269|PubMed:20160912, ECO:0000269|PubMed:20385101, ECO:0000269|PubMed:29211711}.	MISCELLANEOUS: The active site is a redox-active disulfide bond. {ECO:0000250|UniProtKB:P09624}.	acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; branched-chain amino acid catabolic process [GO:0009083]; gastrulation [GO:0007369]; histone succinylation [GO:0106077]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proteolysis [GO:0006508]; regulation of membrane potential [GO:0042391]; sperm capacitation [GO:0048240]	acetyltransferase complex [GO:1902493]; acrosomal matrix [GO:0043159]; mitochondrial alpha-ketoglutarate dehydrogenase complex [GO:0005947]; mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252]; pyruvate dehydrogenase complex [GO:0045254]	dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660]	acetyltransferase complex [GO:1902493]; acrosomal matrix [GO:0043159]; mitochondrial alpha-ketoglutarate dehydrogenase complex [GO:0005947]; mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252]; pyruvate dehydrogenase complex [GO:0045254]; dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660]; acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; branched-chain amino acid catabolic process [GO:0009083]; gastrulation [GO:0007369]; histone succinylation [GO:0106077]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proteolysis [GO:0006508]; regulation of membrane potential [GO:0042391]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:29211711, ECO:0000305|PubMed:3693355}. Nucleus {ECO:0000269|PubMed:29211711}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q811C4}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:15888450}. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation. {ECO:0000269|PubMed:29211711}.
P09629	reviewed	HXB7_HUMAN	Homeobox protein Hox-B7 (Homeobox protein HHO.C1) (Homeobox protein Hox-2C)	HOXB7 HOX2C	Homo sapiens (Human)	217	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; embryonic organ development [GO:0048568]; embryonic skeletal system morphogenesis [GO:0048704]; myeloid cell differentiation [GO:0030099]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; embryonic organ development [GO:0048568]; embryonic skeletal system morphogenesis [GO:0048704]; myeloid cell differentiation [GO:0030099]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P09651	reviewed	ROA1_HUMAN	Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]	HNRNPA1 HNRPA1	Homo sapiens (Human)	372	FUNCTION: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}.	MISCELLANEOUS: [Isoform A1-A]: Is twenty times more abundant than isoform A1-B. {ECO:0000305}.	amyloid fibril formation [GO:1990000]; cellular response to glucose starvation [GO:0042149]; cellular response to sodium arsenite [GO:1903936]; import into nucleus [GO:0051170]; localization [GO:0051179]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear export [GO:0051168]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA export from nucleus [GO:0006405]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]	DNA binding [GO:0003677]; G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; pre-mRNA binding [GO:0036002]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; telomeric repeat-containing RNA binding [GO:0061752]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; DNA binding [GO:0003677]; G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; pre-mRNA binding [GO:0036002]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; telomeric repeat-containing RNA binding [GO:0061752]; amyloid fibril formation [GO:1990000]; cellular response to glucose starvation [GO:0042149]; cellular response to sodium arsenite [GO:1903936]; import into nucleus [GO:0051170]; localization [GO:0051179]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear export [GO:0051168]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA export from nucleus [GO:0006405]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:27694260}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes (PubMed:17289661). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:27694260}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17229681}. Note=(Microbial infection) In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner. {ECO:0000269|PubMed:17229681}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33360543}. Note=(Microbial infection) SARS coronavirus-2/SARS-CoV-2 ORF6 protein increases accumulation to the nucleus. {ECO:0000269|PubMed:33360543}.
P09661	reviewed	RU2A_HUMAN	U2 small nuclear ribonucleoprotein A' (U2 snRNP A')	SNRPA1	Homo sapiens (Human)	255	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:27035939). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128, PubMed:27035939). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:27035939, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9716128}.		mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]	RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620]	catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}.
P09668	reviewed	CATH_HUMAN	Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain]	CTSH CPSB	Homo sapiens (Human)	335	FUNCTION: Important for the overall degradation of proteins in lysosomes.		adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; bradykinin catabolic process [GO:0010815]; cellular response to thyroid hormone stimulus [GO:0097067]; dichotomous subdivision of terminal units involved in lung branching [GO:0060448]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; membrane protein proteolysis [GO:0033619]; metanephros development [GO:0001656]; negative regulation of apoptotic process [GO:0043066]; neuropeptide catabolic process [GO:0010813]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidase activity [GO:0010952]; protein destabilization [GO:0031648]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to retinoic acid [GO:0032526]; surfactant homeostasis [GO:0043129]; T cell mediated cytotoxicity [GO:0001913]; zymogen activation [GO:0031638]	alveolar lamellar body [GO:0097208]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; multivesicular body lumen [GO:0097486]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]	aminopeptidase activity [GO:0004177]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175]; HLA-A specific activating MHC class I receptor activity [GO:0030108]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; thyroid hormone binding [GO:0070324]	alveolar lamellar body [GO:0097208]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; multivesicular body lumen [GO:0097486]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]; aminopeptidase activity [GO:0004177]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175]; HLA-A specific activating MHC class I receptor activity [GO:0030108]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; thyroid hormone binding [GO:0070324]; adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; bradykinin catabolic process [GO:0010815]; cellular response to thyroid hormone stimulus [GO:0097067]; dichotomous subdivision of terminal units involved in lung branching [GO:0060448]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; membrane protein proteolysis [GO:0033619]; metanephros development [GO:0001656]; negative regulation of apoptotic process [GO:0043066]; neuropeptide catabolic process [GO:0010813]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidase activity [GO:0010952]; protein destabilization [GO:0031648]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to retinoic acid [GO:0032526]; surfactant homeostasis [GO:0043129]; T cell mediated cytotoxicity [GO:0001913]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Lysosome.
P09669	reviewed	COX6C_HUMAN	Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc)	COX6C	Homo sapiens (Human)	75	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04038}.		cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
P09681	reviewed	GIP_HUMAN	Gastric inhibitory polypeptide (GIP) (Glucose-dependent insulinotropic polypeptide) (Incretin hormone)	GIP	Homo sapiens (Human)	153	FUNCTION: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adult locomotory behavior [GO:0008344]; digestive system development [GO:0055123]; endocrine pancreas development [GO:0031018]; exploration behavior [GO:0035640]; female pregnancy [GO:0007565]; gastric inhibitory peptide signaling pathway [GO:0038192]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of insulin secretion [GO:0032024]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of insulin secretion [GO:0050796]; response to acidic pH [GO:0010447]; response to amino acid [GO:0043200]; response to axon injury [GO:0048678]; response to glucose [GO:0009749]; response to lipid [GO:0033993]; response to organic cyclic compound [GO:0014070]; response to peptide hormone [GO:0043434]; response to selenium ion [GO:0010269]; response to starvation [GO:0042594]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; triglyceride homeostasis [GO:0070328]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; secretory granule lumen [GO:0034774]	gastric inhibitory polypeptide receptor binding [GO:0031767]; glucagon receptor binding [GO:0031769]; hormone activity [GO:0005179]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; secretory granule lumen [GO:0034774]; gastric inhibitory polypeptide receptor binding [GO:0031767]; glucagon receptor binding [GO:0031769]; hormone activity [GO:0005179]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adult locomotory behavior [GO:0008344]; digestive system development [GO:0055123]; endocrine pancreas development [GO:0031018]; exploration behavior [GO:0035640]; female pregnancy [GO:0007565]; gastric inhibitory peptide signaling pathway [GO:0038192]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of insulin secretion [GO:0032024]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of insulin secretion [GO:0050796]; response to acidic pH [GO:0010447]; response to amino acid [GO:0043200]; response to axon injury [GO:0048678]; response to glucose [GO:0009749]; response to lipid [GO:0033993]; response to organic cyclic compound [GO:0014070]; response to peptide hormone [GO:0043434]; response to selenium ion [GO:0010269]; response to starvation [GO:0042594]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Secreted.
P09683	reviewed	SECR_HUMAN	Secretin	SCT	Homo sapiens (Human)	121	FUNCTION: Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973). Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells (PubMed:25332973). Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content (By similarity). Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (Probable). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (By similarity). Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity). {ECO:0000250|UniProtKB:P11384, ECO:0000250|UniProtKB:Q08535, ECO:0000303|PubMed:25332973, ECO:0000305|PubMed:30449620}.		brain development [GO:0007420]; diet induced thermogenesis [GO:0002024]; embryonic digestive tract development [GO:0048566]; hippocampus development [GO:0021766]; intracellular water homeostasis [GO:0009992]; negative regulation of gastrin-induced gastric acid secretion [GO:1903640]; pancreatic juice secretion [GO:0030157]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of pancreatic juice secretion [GO:0090187]; positive regulation of somatostatin secretion [GO:0090274]; regulation of appetite [GO:0032098]; regulation of synaptic plasticity [GO:0048167]; response to nutrient levels [GO:0031667]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	digestive hormone activity [GO:0046659]; G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; digestive hormone activity [GO:0046659]; G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; brain development [GO:0007420]; diet induced thermogenesis [GO:0002024]; embryonic digestive tract development [GO:0048566]; hippocampus development [GO:0021766]; intracellular water homeostasis [GO:0009992]; negative regulation of gastrin-induced gastric acid secretion [GO:1903640]; pancreatic juice secretion [GO:0030157]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of pancreatic juice secretion [GO:0090187]; positive regulation of somatostatin secretion [GO:0090274]; regulation of appetite [GO:0032098]; regulation of synaptic plasticity [GO:0048167]; response to nutrient levels [GO:0031667]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.2}.
P09693	reviewed	CD3G_HUMAN	T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)	CD3G T3G	Homo sapiens (Human)	182	FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. {ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:8187769, ECO:0000269|PubMed:8636209}.		adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; cell surface receptor signaling pathway [GO:0007166]; establishment or maintenance of cell polarity [GO:0007163]; gamma-delta T cell activation [GO:0046629]; positive thymic T cell selection [GO:0045059]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; regulation of lymphocyte apoptotic process [GO:0070228]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]	alpha-beta T cell receptor complex [GO:0042105]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; gamma-delta T cell receptor complex [GO:0042106]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; signaling receptor complex adaptor activity [GO:0030159]; T cell receptor binding [GO:0042608]; transmembrane signaling receptor activity [GO:0004888]	alpha-beta T cell receptor complex [GO:0042105]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; gamma-delta T cell receptor complex [GO:0042106]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; signaling receptor complex adaptor activity [GO:0030159]; T cell receptor binding [GO:0042608]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; cell surface receptor signaling pathway [GO:0007166]; establishment or maintenance of cell polarity [GO:0007163]; gamma-delta T cell activation [GO:0046629]; positive thymic T cell selection [GO:0045059]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; regulation of lymphocyte apoptotic process [GO:0070228]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8636209}; Single-pass type I membrane protein.
P09758	reviewed	TACD2_HUMAN	Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2) (Membrane component chromosome 1 surface marker 1) (Pancreatic carcinoma marker protein GA733-1)	TACSTD2 GA733-1 M1S1 TROP2	Homo sapiens (Human)	323	FUNCTION: May function as a growth factor receptor.		negative regulation of branching involved in ureteric bud morphogenesis [GO:0090191]; negative regulation of cell motility [GO:2000146]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of stem cell differentiation [GO:2000738]; regulation of epithelial cell proliferation [GO:0050678]; response to stimulus [GO:0050896]; ureteric bud morphogenesis [GO:0060675]; visual perception [GO:0007601]	basal plasma membrane [GO:0009925]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; nucleus [GO:0005634]		basal plasma membrane [GO:0009925]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; nucleus [GO:0005634]; negative regulation of branching involved in ureteric bud morphogenesis [GO:0090191]; negative regulation of cell motility [GO:2000146]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of stem cell differentiation [GO:2000738]; regulation of epithelial cell proliferation [GO:0050678]; response to stimulus [GO:0050896]; ureteric bud morphogenesis [GO:0060675]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P09769	reviewed	FGR_HUMAN	Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)	FGR SRC2	Homo sapiens (Human)	529	FUNCTION: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}.		bone mineralization [GO:0030282]; cell differentiation [GO:0030154]; defense response to Gram-positive bacterium [GO:0050830]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; myoblast proliferation [GO:0051450]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of natural killer cell activation [GO:0032815]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokine production [GO:0001819]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; regulation of innate immune response [GO:0045088]; regulation of phagocytosis [GO:0050764]; regulation of protein kinase activity [GO:0045859]; response to virus [GO:0009615]; skeletal system morphogenesis [GO:0048705]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	actin cytoskeleton [GO:0015629]; aggresome [GO:0016235]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; secretory granule lumen [GO:0034774]	ATP binding [GO:0005524]; Fc-gamma receptor I complex binding [GO:0034988]; immunoglobulin receptor binding [GO:0034987]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]	actin cytoskeleton [GO:0015629]; aggresome [GO:0016235]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; secretory granule lumen [GO:0034774]; ATP binding [GO:0005524]; Fc-gamma receptor I complex binding [GO:0034988]; immunoglobulin receptor binding [GO:0034987]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; bone mineralization [GO:0030282]; cell differentiation [GO:0030154]; defense response to Gram-positive bacterium [GO:0050830]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; myoblast proliferation [GO:0051450]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of natural killer cell activation [GO:0032815]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokine production [GO:0001819]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; regulation of innate immune response [GO:0045088]; regulation of phagocytosis [GO:0050764]; regulation of protein kinase activity [GO:0045859]; response to virus [GO:0009615]; skeletal system morphogenesis [GO:0048705]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}. Note=Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. {ECO:0000250}.
P09848	reviewed	LPH_HUMAN	Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)]	LCT LPH	Homo sapiens (Human)	1927	FUNCTION: Broad specificity glycosidase of the intestinal brush border membrane that hydrolyzes lactose, the main sugar in mammalian milk, to produce D-glucose and D-galactose (PubMed:3929764, PubMed:9762914, PubMed:12594539, PubMed:16400612). The mature protein is composed of two domains that catalyze the hydrolysis of beta-glucopyranosides and beta-galactopyranosides, with a preference for hydrophilic aglycones (in lactose and cellobiose) for one domain and hydrophobic aglycones (in phlorizin and glycosylceramides) for the other (PubMed:3929764, PubMed:9762914, PubMed:12594539). {ECO:0000269|PubMed:12594539, ECO:0000269|PubMed:16400612, ECO:0000269|PubMed:3929764, ECO:0000269|PubMed:9762914}.		cellobiose catabolic process [GO:2000892]; glycosylceramide catabolic process [GO:0046477]; lactose catabolic process [GO:0005990]; quercetin catabolic process [GO:1901733]	external side of apical plasma membrane [GO:0098591]; plasma membrane [GO:0005886]	beta-glucosidase activity [GO:0008422]; cellobiose glucosidase activity [GO:0080079]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glycosylceramidase activity [GO:0017042]; lactase activity [GO:0000016]; phlorizin hydrolase activity [GO:0140749]; protein homodimerization activity [GO:0042803]	external side of apical plasma membrane [GO:0098591]; plasma membrane [GO:0005886]; beta-glucosidase activity [GO:0008422]; cellobiose glucosidase activity [GO:0080079]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glycosylceramidase activity [GO:0017042]; lactase activity [GO:0000016]; phlorizin hydrolase activity [GO:0140749]; protein homodimerization activity [GO:0042803]; cellobiose catabolic process [GO:2000892]; glycosylceramide catabolic process [GO:0046477]; lactose catabolic process [GO:0005990]; quercetin catabolic process [GO:1901733]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:9593732}; Single-pass type I membrane protein {ECO:0000305|PubMed:9593732}. Note=Brush border. {ECO:0000250|UniProtKB:P09849}.
P09871	reviewed	C1S_HUMAN	Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain]	C1S	Homo sapiens (Human)	688	FUNCTION: C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.		complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; proteolysis [GO:0006508]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; proteolysis [GO:0006508]	
P09874	reviewed	PARP1_HUMAN	Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]	PARP1 ADPRT PPOL	Homo sapiens (Human)	1014	FUNCTION: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18172500, PubMed:20388712, PubMed:19344625, PubMed:19661379, PubMed:21680843, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:32028527, PubMed:30104678, PubMed:33186521, PubMed:31796734, PubMed:32358582, PubMed:34737271, PubMed:34465625, PubMed:18055453, PubMed:22582261, PubMed:26626479, PubMed:26626480, PubMed:32241924). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:7852410, PubMed:9315851, PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:34874266, PubMed:34625544, PubMed:33589610). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:34874266, PubMed:34625544, PubMed:33589610). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:30257210, PubMed:29954836). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34874266, PubMed:34465625). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:34732825, PubMed:33683197, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:17177976, PubMed:19344625, PubMed:15607977, PubMed:27256882, PubMed:32844745, PubMed:32315358, PubMed:35124853, PubMed:35460603, PubMed:35393539). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32844745, PubMed:32315358, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}.		apoptotic process [GO:0006915]; ATP generation from poly-ADP-D-ribose [GO:1990966]; carbohydrate biosynthetic process [GO:0016051]; cellular response to amyloid-beta [GO:1904646]; cellular response to insulin stimulus [GO:0032869]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; cellular response to zinc ion [GO:0071294]; decidualization [GO:0046697]; DNA ADP-ribosylation [GO:0030592]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; macrophage differentiation [GO:0030225]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of innate immune response [GO:0045824]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of myofibroblast differentiation [GO:1904762]; positive regulation of necroptotic process [GO:0060545]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of single strand break repair [GO:1903518]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein auto-ADP-ribosylation [GO:0070213]; protein autoprocessing [GO:0016540]; protein localization to chromatin [GO:0071168]; protein modification process [GO:0036211]; protein poly-ADP-ribosylation [GO:0070212]; regulation of base-excision repair [GO:1905051]; regulation of catalytic activity [GO:0050790]; regulation of circadian sleep/wake cycle, non-REM sleep [GO:0045188]; regulation of DNA methylation [GO:0044030]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376]; regulation of protein localization [GO:0032880]; replication fork reversal [GO:0071932]; response to aldosterone [GO:1904044]; response to gamma radiation [GO:0010332]; signal transduction involved in regulation of gene expression [GO:0023019]; telomere maintenance [GO:0000723]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-histone H2BS6 serine ADP-ribosyltransferase activity [GO:0140816]; NAD+-histone H3S10 serine ADP-ribosyltransferase activity [GO:0140817]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-histidine ADP-ribosyltransferase activity [GO:0140815]; NAD+-protein-serine ADP-ribosyltransferase activity [GO:0140805]; NAD+-protein-tyrosine ADP-ribosyltransferase activity [GO:0140808]; nuclear estrogen receptor binding [GO:0030331]; nucleosome binding [GO:0031491]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-histone H2BS6 serine ADP-ribosyltransferase activity [GO:0140816]; NAD+-histone H3S10 serine ADP-ribosyltransferase activity [GO:0140817]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-histidine ADP-ribosyltransferase activity [GO:0140815]; NAD+-protein-serine ADP-ribosyltransferase activity [GO:0140805]; NAD+-protein-tyrosine ADP-ribosyltransferase activity [GO:0140808]; nuclear estrogen receptor binding [GO:0030331]; nucleosome binding [GO:0031491]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; ATP generation from poly-ADP-D-ribose [GO:1990966]; carbohydrate biosynthetic process [GO:0016051]; cellular response to amyloid-beta [GO:1904646]; cellular response to insulin stimulus [GO:0032869]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; cellular response to zinc ion [GO:0071294]; decidualization [GO:0046697]; DNA ADP-ribosylation [GO:0030592]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; macrophage differentiation [GO:0030225]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of innate immune response [GO:0045824]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of myofibroblast differentiation [GO:1904762]; positive regulation of necroptotic process [GO:0060545]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of single strand break repair [GO:1903518]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein auto-ADP-ribosylation [GO:0070213]; protein autoprocessing [GO:0016540]; protein localization to chromatin [GO:0071168]; protein modification process [GO:0036211]; protein poly-ADP-ribosylation [GO:0070212]; regulation of base-excision repair [GO:1905051]; regulation of catalytic activity [GO:0050790]; regulation of circadian sleep/wake cycle, non-REM sleep [GO:0045188]; regulation of DNA methylation [GO:0044030]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376]; regulation of protein localization [GO:0032880]; replication fork reversal [GO:0071932]; response to aldosterone [GO:1904044]; response to gamma radiation [GO:0010332]; signal transduction involved in regulation of gene expression [GO:0023019]; telomere maintenance [GO:0000723]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:22683995, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:30675909, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:35013556}. Nucleus {ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:21799911, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:35460603}. Nucleus, nucleolus {ECO:0000269|PubMed:9518481}. Cytoplasm, cytosol {ECO:0000269|PubMed:35460603}. Note=Localizes to sites of DNA damage (PubMed:23230272, PubMed:26344098, PubMed:27568560, PubMed:30675909, PubMed:34625544, PubMed:34795260, PubMed:32358582, PubMed:22683995, PubMed:32241924). Recognizes (via PARP-type zinc-fingers) and binds DNA strand breaks (PubMed:22683995). Also binds normal/undamaged chromatin (PubMed:15607977). Auto poly-ADP-ribosylation promotes dissociation from chromatin (PubMed:15607977, PubMed:30675909, PubMed:32358582, PubMed:34625544). Extracted from chromatin by VCP/p97 following sumoylation and ubiquitination (PubMed:35013556). Translocates from the nucleus to the cytosol following phosphorylation by PRKDC (PubMed:35460603). Recruited to replication forks following interaction with CARM1 (PubMed:33412112). {ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:22683995, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:30675909, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:35013556, ECO:0000269|PubMed:35460603}.; SUBCELLULAR LOCATION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome {ECO:0000269|PubMed:33168626, ECO:0000269|PubMed:35104452, ECO:0000269|PubMed:9721847}. Note=Following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, this cleavage form irreversibly binds to DNA breaks. {ECO:0000269|PubMed:33168626, ECO:0000269|PubMed:35104452, ECO:0000269|PubMed:9721847}.; SUBCELLULAR LOCATION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm {ECO:0000269|PubMed:33168626}. Note=Following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, translocates into the cytoplasm, where the auto-poly-ADP-ribosylated form serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis. {ECO:0000269|PubMed:33168626}.
P09884	reviewed	DPOLA_HUMAN	DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180)	POLA1 POLA	Homo sapiens (Human)	1462	FUNCTION: Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). {ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:27019227, ECO:0000269|PubMed:31006512, ECO:0000269|PubMed:9518481}.	MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.	DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair via nonhomologous end joining [GO:0006303]; lagging strand elongation [GO:0006273]; leading strand elongation [GO:0006272]; mitotic DNA replication initiation [GO:1902975]; regulation of type I interferon production [GO:0032479]	alpha DNA polymerase:primase complex [GO:0005658]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA replication origin binding [GO:0003688]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166]; protein kinase binding [GO:0019901]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270]	alpha DNA polymerase:primase complex [GO:0005658]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA replication origin binding [GO:0003688]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166]; protein kinase binding [GO:0019901]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair via nonhomologous end joining [GO:0006303]; lagging strand elongation [GO:0006273]; leading strand elongation [GO:0006272]; mitotic DNA replication initiation [GO:1902975]; regulation of type I interferon production [GO:0032479]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27019227}. Cytoplasm, cytosol {ECO:0000269|PubMed:27019227}. Note=In the cytosol, colocalizes with RNA:DNA hybrids with a speckled pattern. {ECO:0000269|PubMed:27019227}.
P09912	reviewed	IFI6_HUMAN	Interferon alpha-inducible protein 6 (Interferon-induced protein 6-16) (Ifi-6-16)	IFI6 G1P3	Homo sapiens (Human)	130	FUNCTION: Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses (PubMed:31142663). Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication (PubMed:30224801). Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells (PubMed:25757571). Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression (PubMed:33868257). Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642). However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746). Modulates innate immune response mediated by RIGI by preventing its activation (PubMed:36793726). {ECO:0000269|PubMed:15685448, ECO:0000269|PubMed:17823654, ECO:0000269|PubMed:25757571, ECO:0000269|PubMed:26244642, ECO:0000269|PubMed:27673746, ECO:0000269|PubMed:30224801, ECO:0000269|PubMed:31142663, ECO:0000269|PubMed:33868257, ECO:0000269|PubMed:36793726}.		apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; immune response [GO:0006955]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of mitochondrial depolarization [GO:0051902]; reactive oxygen species metabolic process [GO:0072593]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; release of cytochrome c from mitochondria [GO:0001836]	endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]		endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; immune response [GO:0006955]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of mitochondrial depolarization [GO:0051902]; reactive oxygen species metabolic process [GO:0072593]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; release of cytochrome c from mitochondria [GO:0001836]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30224801, ECO:0000269|PubMed:31142663}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:15685448, ECO:0000269|PubMed:17823654, ECO:0000269|PubMed:25757571, ECO:0000269|PubMed:27673746, ECO:0000269|PubMed:29899394}; Multi-pass membrane protein {ECO:0000255}.
P09913	reviewed	IFIT2_HUMAN	Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (ISG-54 K) (Interferon-induced 54 kDa protein) (IFI-54K) (P54)	IFIT2 CIG-42 G10P2 IFI54 ISG54	Homo sapiens (Human)	472	FUNCTION: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. {ECO:0000269|PubMed:21190939}.		antiviral innate immune response [GO:0140374]; apoptotic mitochondrial changes [GO:0008637]; defense response to virus [GO:0051607]; negative regulation of protein binding [GO:0032091]; positive regulation of apoptotic process [GO:0043065]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; RNA binding [GO:0003723]; antiviral innate immune response [GO:0140374]; apoptotic mitochondrial changes [GO:0008637]; defense response to virus [GO:0051607]; negative regulation of protein binding [GO:0032091]; positive regulation of apoptotic process [GO:0043065]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21190939}. Endoplasmic reticulum {ECO:0000269|PubMed:21190939}.
P09914	reviewed	IFIT1_HUMAN	Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56)	IFIT1 G10P1 IFI56 IFNAI1 ISG56	Homo sapiens (Human)	478	FUNCTION: Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:19416887, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420}.		antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to type I interferon [GO:0071357]; defense response to virus [GO:0051607]; intracellular transport of viral protein in host cell [GO:0019060]; negative regulation of helicase activity [GO:0051097]; negative regulation of protein binding [GO:0032091]; negative regulation of viral genome replication [GO:0045071]; positive regulation of viral genome replication [GO:0045070]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; host cell [GO:0043657]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; host cell [GO:0043657]; RNA binding [GO:0003723]; antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to type I interferon [GO:0071357]; defense response to virus [GO:0051607]; intracellular transport of viral protein in host cell [GO:0019060]; negative regulation of helicase activity [GO:0051097]; negative regulation of protein binding [GO:0032091]; negative regulation of viral genome replication [GO:0045071]; positive regulation of viral genome replication [GO:0045070]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:21642987}.
P09917	reviewed	LOX5_HUMAN	Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34)	ALOX5 LOG5	Homo sapiens (Human)	674	FUNCTION: Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:8631361, PubMed:21233389, PubMed:22516296, PubMed:24282679, PubMed:19022417, PubMed:23246375, PubMed:8615788, PubMed:24893149, PubMed:31664810). Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE) (PubMed:23246375). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene (PubMed:31664810). Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (PubMed:21206090, PubMed:31664810, PubMed:8615788, PubMed:17114001, PubMed:32404334). Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma) (By similarity). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31664810). In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (By similarity). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 (PubMed:21200133). May also play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P48999, ECO:0000269|PubMed:17114001, ECO:0000269|PubMed:19022417, ECO:0000269|PubMed:21200133, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:21233389, ECO:0000269|PubMed:22516296, ECO:0000269|PubMed:23246375, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:24893149, ECO:0000269|PubMed:31664810, ECO:0000269|PubMed:32404334, ECO:0000269|PubMed:8615788, ECO:0000269|PubMed:8631361}.		arachidonic acid metabolic process [GO:0019369]; dendritic cell migration [GO:0036336]; glucose homeostasis [GO:0042593]; hepoxilin biosynthetic process [GO:0051122]; humoral immune response [GO:0006959]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; leukocyte migration involved in inflammatory response [GO:0002523]; leukotriene A4 biosynthetic process [GO:1901753]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene production involved in inflammatory response [GO:0002540]; linoleic acid metabolic process [GO:0043651]; lipid oxidation [GO:0034440]; lipoxin biosynthetic process [GO:2001301]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of inflammatory response [GO:0050728]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; positive regulation of bone mineralization [GO:0030501]; positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of fat cell differentiation [GO:0045598]; regulation of inflammatory response [GO:0050727]; regulation of inflammatory response to wounding [GO:0106014]; regulation of insulin secretion [GO:0050796]; regulation of reactive oxygen species biosynthetic process [GO:1903426]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nuclear envelope [GO:0005635]; nuclear envelope lumen [GO:0005641]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; secretory granule lumen [GO:0034774]	arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 5-lipoxygenase activity [GO:0004051]; arachidonate 8(S)-lipoxygenase activity [GO:0036403]; hydrolase activity [GO:0016787]; iron ion binding [GO:0005506]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nuclear envelope [GO:0005635]; nuclear envelope lumen [GO:0005641]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; secretory granule lumen [GO:0034774]; arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 5-lipoxygenase activity [GO:0004051]; arachidonate 8(S)-lipoxygenase activity [GO:0036403]; hydrolase activity [GO:0016787]; iron ion binding [GO:0005506]; arachidonic acid metabolic process [GO:0019369]; dendritic cell migration [GO:0036336]; glucose homeostasis [GO:0042593]; hepoxilin biosynthetic process [GO:0051122]; humoral immune response [GO:0006959]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; leukocyte migration involved in inflammatory response [GO:0002523]; leukotriene A4 biosynthetic process [GO:1901753]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene production involved in inflammatory response [GO:0002540]; linoleic acid metabolic process [GO:0043651]; lipid oxidation [GO:0034440]; lipoxin biosynthetic process [GO:2001301]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of inflammatory response [GO:0050728]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; positive regulation of bone mineralization [GO:0030501]; positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of fat cell differentiation [GO:0045598]; regulation of inflammatory response [GO:0050727]; regulation of inflammatory response to wounding [GO:0106014]; regulation of insulin secretion [GO:0050796]; regulation of reactive oxygen species biosynthetic process [GO:1903426]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P48999, ECO:0000269|PubMed:18978352}. Nucleus matrix {ECO:0000269|PubMed:19233132}. Nucleus membrane {ECO:0000269|PubMed:16275640}; Peripheral membrane protein {ECO:0000269|PubMed:16275640}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19022417}. Cytoplasm, cytosol {ECO:0000269|PubMed:19233132}. Nucleus envelope {ECO:0000269|PubMed:16275640, ECO:0000269|PubMed:19233132, ECO:0000269|PubMed:8245774}. Nucleus intermembrane space {ECO:0000269|PubMed:8245774}. Note=Shuttles between cytoplasm and nucleus (PubMed:19233132). Found exclusively in the nucleus, when phosphorylated on Ser-272 (PubMed:18978352). Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association (PubMed:19233132, PubMed:3118366, PubMed:8245774, PubMed:16275640). {ECO:0000269|PubMed:16275640, ECO:0000269|PubMed:18978352, ECO:0000269|PubMed:19233132, ECO:0000269|PubMed:3118366, ECO:0000269|PubMed:8245774}.
P09919	reviewed	CSF3_HUMAN	Granulocyte colony-stimulating factor (G-CSF) (Pluripoietin) (Filgrastim) (Lenograstim)	CSF3 C17orf33 GCSF	Homo sapiens (Human)	207	FUNCTION: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.		cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; granulocyte differentiation [GO:0030851]; immune response [GO:0006955]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin filament organization [GO:0110053]; response to ethanol [GO:0045471]	endocytic vesicle lumen [GO:0071682]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]	cytokine activity [GO:0005125]; enzyme binding [GO:0019899]; granulocyte colony-stimulating factor receptor binding [GO:0005130]; growth factor activity [GO:0008083]	endocytic vesicle lumen [GO:0071682]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; cytokine activity [GO:0005125]; enzyme binding [GO:0019899]; granulocyte colony-stimulating factor receptor binding [GO:0005130]; growth factor activity [GO:0008083]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; granulocyte differentiation [GO:0030851]; immune response [GO:0006955]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin filament organization [GO:0110053]; response to ethanol [GO:0045471]	SUBCELLULAR LOCATION: Secreted.
P09923	reviewed	PPBI_HUMAN	Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1)	ALPI	Homo sapiens (Human)	528	FUNCTION: Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}.	MISCELLANEOUS: In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non-specific (liver/bone/kidney) (ALPL/TNAP).	dephosphorylation [GO:0016311]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	alkaline phosphatase activity [GO:0004035]; magnesium ion binding [GO:0000287]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; alkaline phosphatase activity [GO:0004035]; magnesium ion binding [GO:0000287]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]; dephosphorylation [GO:0016311]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P15693}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P15693}.
P09936	reviewed	UCHL1_HUMAN	Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)	UCHL1	Homo sapiens (Human)	223	FUNCTION: Deubiquitinase that plays a role in the regulation of several processes such as maintenance of synaptic function, cardiac function, inflammatory response or osteoclastogenesis (PubMed:22212137, PubMed:23359680). Abrogates the ubiquitination of multiple proteins including WWTR1/TAZ, EGFR, HIF1A and beta-site amyloid precursor protein cleaving enzyme 1/BACE1 (PubMed:22212137, PubMed:25615526). In addition, recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin to maintain a stable pool of monoubiquitin that is a key requirement for the ubiquitin-proteasome and the autophagy-lysosome pathways (PubMed:9774100, PubMed:8639624, PubMed:12408865). Regulates amyloid precursor protein/APP processing by promoting BACE1 degradation resulting in decreased amyloid beta production (PubMed:22212137). Plays a role in the immune response by regulating the ability of MHC I molecules to reach cross-presentation compartments competent for generating Ag-MHC I complexes (By similarity). Mediates the 'Lys-48'-linked deubiquitination of the transcriptional coactivator WWTR1/TAZ leading to its stabilization and inhibition of osteoclastogenesis (By similarity). Deubiquitinates and stabilizes epidermal growth factor receptor EGFR to prevent its degradation and to activate its downstream mediators (By similarity). Modulates oxidative activity in skeletal muscle by regulating key mitochondrial oxidative proteins (By similarity). Enhances the activity of hypoxia-inducible factor 1-alpha/HIF1A by abrogateing its VHL E3 ligase-mediated ubiquitination and consequently inhibiting its degradation (PubMed:25615526). {ECO:0000250|UniProtKB:Q9R0P9, ECO:0000269|PubMed:12408865, ECO:0000269|PubMed:22212137, ECO:0000269|PubMed:23359680, ECO:0000269|PubMed:25615526, ECO:0000269|PubMed:8639624, ECO:0000269|PubMed:9774100}.	MISCELLANEOUS: Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles. In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.	adult walking behavior [GO:0007628]; axon target recognition [GO:0007412]; axonal transport of mitochondrion [GO:0019896]; cellular response to xenobiotic stimulus [GO:0071466]; eating behavior [GO:0042755]; male germ cell proliferation [GO:0002176]; muscle cell development [GO:0055001]; negative regulation of MAP kinase activity [GO:0043407]; neuromuscular process [GO:0050905]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of macroautophagy [GO:0016241]; response to ischemia [GO:0002931]	axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]	alpha-2A adrenergic receptor binding [GO:0031694]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; omega peptidase activity [GO:0008242]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]	axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; alpha-2A adrenergic receptor binding [GO:0031694]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; omega peptidase activity [GO:0008242]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; adult walking behavior [GO:0007628]; axon target recognition [GO:0007412]; axonal transport of mitochondrion [GO:0019896]; cellular response to xenobiotic stimulus [GO:0071466]; eating behavior [GO:0042755]; male germ cell proliferation [GO:0002176]; muscle cell development [GO:0055001]; negative regulation of MAP kinase activity [GO:0043407]; neuromuscular process [GO:0050905]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of macroautophagy [GO:0016241]; response to ischemia [GO:0002931]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19261853}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19261853}; Lipid-anchor {ECO:0000269|PubMed:19261853}. Note=About 30% of total UCHL1 is associated with membranes in brain. Localizes near and/or within mitochondria to potentially interact with mitochondrial proteins. {ECO:0000250|UniProtKB:Q9R0P9}.
P09958	reviewed	FURIN_HUMAN	Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE)	FURIN FUR PACE PCSK3	Homo sapiens (Human)	794	FUNCTION: Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) (PubMed:20489134, PubMed:21763278). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (By similarity). {ECO:0000250|UniProtKB:P23188, ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:1629222, ECO:0000269|PubMed:1713771, ECO:0000269|PubMed:20489134, ECO:0000269|PubMed:21763278, ECO:0000269|PubMed:2251280, ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0000269|PubMed:7592877, ECO:0000269|PubMed:7690548, ECO:0000269|PubMed:7737999, ECO:0000269|PubMed:9130696}.; FUNCTION: (Microbial infection) Cleaves and activates diphtheria toxin DT. {ECO:0000269|PubMed:8253774}.; FUNCTION: (Microbial infection) Cleaves and activates anthrax toxin protective antigen (PA). {ECO:0000269|PubMed:1438214, ECO:0000269|PubMed:1644824}.; FUNCTION: (Microbial infection) Cleaves and activates HIV-1 virus Envelope glycoprotein gp160. {ECO:0000269|PubMed:31091448}.; FUNCTION: (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. {ECO:0000269|PubMed:25974265}.; FUNCTION: (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP. {ECO:0000269|PubMed:27582320}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses EMC and SARS-CoV-2 infections by proteolytically cleaving the spike protein at the monobasic S1/S2 cleavage site. This cleavage is essential for spike protein-mediated cell-cell fusion and entry into human lung cells. {ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818}.; FUNCTION: (Microbial infection) Facilitates mumps virus infection by proteolytically cleaving the viral fusion protein F. {ECO:0000269|PubMed:32295904}.		amyloid fibril formation [GO:1990000]; blastocyst formation [GO:0001825]; collagen catabolic process [GO:0030574]; cytokine precursor processing [GO:0140447]; dibasic protein processing [GO:0090472]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor production [GO:0032902]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; plasma lipoprotein particle remodeling [GO:0034369]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of viral entry into host cell [GO:0046598]; protein maturation [GO:0051604]; protein processing [GO:0016485]; regulation of cholesterol transport [GO:0032374]; regulation of endopeptidase activity [GO:0052548]; regulation of protein catabolic process [GO:0042176]; regulation of signal transduction [GO:0009966]; secretion by cell [GO:0032940]; signal peptide processing [GO:0006465]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral life cycle [GO:0019058]; viral protein processing [GO:0019082]; viral translation [GO:0019081]; zymogen activation [GO:0031638]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]	endopeptidase activity [GO:0004175]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; nerve growth factor binding [GO:0048406]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; serine-type endopeptidase inhibitor activity [GO:0004867]; serine-type peptidase activity [GO:0008236]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]; endopeptidase activity [GO:0004175]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; nerve growth factor binding [GO:0048406]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; serine-type endopeptidase inhibitor activity [GO:0004867]; serine-type peptidase activity [GO:0008236]; amyloid fibril formation [GO:1990000]; blastocyst formation [GO:0001825]; collagen catabolic process [GO:0030574]; cytokine precursor processing [GO:0140447]; dibasic protein processing [GO:0090472]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor production [GO:0032902]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; plasma lipoprotein particle remodeling [GO:0034369]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of viral entry into host cell [GO:0046598]; protein maturation [GO:0051604]; protein processing [GO:0016485]; regulation of cholesterol transport [GO:0032374]; regulation of endopeptidase activity [GO:0052548]; regulation of protein catabolic process [GO:0042176]; regulation of signal transduction [GO:0009966]; secretion by cell [GO:0032940]; signal peptide processing [GO:0006465]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral life cycle [GO:0019058]; viral protein processing [GO:0019082]; viral translation [GO:0019081]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:8846780, ECO:0000269|PubMed:9130696, ECO:0000269|PubMed:9412467}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:9130696, ECO:0000269|PubMed:9412467}; Single-pass type I membrane protein {ECO:0000305}. Secreted {ECO:0000305|PubMed:11799113}. Endosome membrane {ECO:0000269|PubMed:9412467}; Single-pass type I membrane protein {ECO:0000305}. Note=Shuttles between the trans-Golgi network and the cell surface (PubMed:9412467, PubMed:11799113). Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin (PubMed:11799113). {ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:9412467}.
P09960	reviewed	LKHA4_HUMAN	Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4)	LTA4H LTA4	Homo sapiens (Human)	611	FUNCTION: Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}.		leukotriene biosynthetic process [GO:0019370]; lipid metabolic process [GO:0006629]; peptide catabolic process [GO:0043171]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]; response to peptide hormone [GO:0043434]; response to zinc ion [GO:0010043]; type I pneumocyte differentiation [GO:0060509]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]	aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; leukotriene-A4 hydrolase activity [GO:0004463]; metalloaminopeptidase activity [GO:0070006]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]; tripeptide aminopeptidase activity [GO:0045148]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]; aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; leukotriene-A4 hydrolase activity [GO:0004463]; metalloaminopeptidase activity [GO:0070006]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]; tripeptide aminopeptidase activity [GO:0045148]; zinc ion binding [GO:0008270]; leukotriene biosynthetic process [GO:0019370]; lipid metabolic process [GO:0006629]; peptide catabolic process [GO:0043171]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]; response to peptide hormone [GO:0043434]; response to zinc ion [GO:0010043]; type I pneumocyte differentiation [GO:0060509]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:6490615}.
P09972	reviewed	ALDOC_HUMAN	Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase)	ALDOC ALDC	Homo sapiens (Human)	364		MISCELLANEOUS: In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.	epithelial cell differentiation [GO:0030855]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]	cytoskeletal protein binding [GO:0008092]; fructose-bisphosphate aldolase activity [GO:0004332]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]; cytoskeletal protein binding [GO:0008092]; fructose-bisphosphate aldolase activity [GO:0004332]; epithelial cell differentiation [GO:0030855]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]	
P0C024	reviewed	NUDT7_HUMAN	Peroxisomal coenzyme A diphosphatase NUDT7 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 7) (Nudix motif 7)	NUDT7	Homo sapiens (Human)	238	FUNCTION: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (By similarity). Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (By similarity). Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (By similarity). May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (By similarity). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). {ECO:0000250|UniProtKB:Q99P30}.		acetyl-CoA catabolic process [GO:0046356]; brown fat cell differentiation [GO:0050873]; butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; nucleoside diphosphate metabolic process [GO:0009132]; propionyl-CoA catabolic process [GO:1902859]; propionyl-CoA metabolic process [GO:1902858]; succinyl-CoA catabolic process [GO:1901289]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	CoA pyrophosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; snoRNA binding [GO:0030515]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; CoA pyrophosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; snoRNA binding [GO:0030515]; acetyl-CoA catabolic process [GO:0046356]; brown fat cell differentiation [GO:0050873]; butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; nucleoside diphosphate metabolic process [GO:0009132]; propionyl-CoA catabolic process [GO:1902859]; propionyl-CoA metabolic process [GO:1902858]; succinyl-CoA catabolic process [GO:1901289]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q99P30}.
P0C0L4	reviewed	CO4A_HUMAN	Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain]	C4A CO4 CPAMD2	Homo sapiens (Human)	1744	FUNCTION: Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.; FUNCTION: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.		complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of apoptotic cell clearance [GO:2000427]	axon [GO:0030424]; blood microparticle [GO:0072562]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]	complement component C1q complex binding [GO:0001849]; endopeptidase inhibitor activity [GO:0004866]	axon [GO:0030424]; blood microparticle [GO:0072562]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; complement component C1q complex binding [GO:0001849]; endopeptidase inhibitor activity [GO:0004866]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of apoptotic cell clearance [GO:2000427]	SUBCELLULAR LOCATION: Secreted. Synapse {ECO:0000269|PubMed:26814963}. Cell projection, axon {ECO:0000269|PubMed:26814963}. Cell projection, dendrite {ECO:0000269|PubMed:26814963}.
P0C0L5	reviewed	CO4B_HUMAN	Complement C4-B (Basic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3) [Cleaved into: Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; C4b-B; C4d-B; Complement C4 gamma chain]	C4B CO4 CPAMD3; C4B_2	Homo sapiens (Human)	1744	FUNCTION: Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.; FUNCTION: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.		complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; detection of molecule of bacterial origin [GO:0032490]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; opsonization [GO:0008228]; positive regulation of apoptotic cell clearance [GO:2000427]	axon [GO:0030424]; blood microparticle [GO:0072562]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]; synapse [GO:0045202]	carbohydrate binding [GO:0030246]; complement binding [GO:0001848]; endopeptidase inhibitor activity [GO:0004866]	axon [GO:0030424]; blood microparticle [GO:0072562]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]; synapse [GO:0045202]; carbohydrate binding [GO:0030246]; complement binding [GO:0001848]; endopeptidase inhibitor activity [GO:0004866]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; detection of molecule of bacterial origin [GO:0032490]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; opsonization [GO:0008228]; positive regulation of apoptotic cell clearance [GO:2000427]	SUBCELLULAR LOCATION: Secreted. Synapse {ECO:0000269|PubMed:26814963}. Cell projection, axon {ECO:0000269|PubMed:26814963}. Cell projection, dendrite {ECO:0000269|PubMed:26814963}.
P0C0S5	reviewed	H2AZ_HUMAN	Histone H2A.Z (H2A/z)	H2AZ1 H2AFZ H2AZ	Homo sapiens (Human)	128	FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. {ECO:0000269|PubMed:15878876}.		cellular response to estradiol stimulus [GO:0071392]; chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944]	euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; heterochromatin [GO:0000792]; nucleosome [GO:0000786]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; nucleosomal DNA binding [GO:0031492]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; structural constituent of chromatin [GO:0030527]	euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; heterochromatin [GO:0000792]; nucleosome [GO:0000786]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; nucleosomal DNA binding [GO:0031492]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; structural constituent of chromatin [GO:0030527]; cellular response to estradiol stimulus [GO:0071392]; chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P0C0S8	reviewed	H2A1_HUMAN	Histone H2A type 1 (H2A.1) (Histone H2A/ptl)	H2AC11 H2AFP HIST1H2AG; H2AC13 H2AFC HIST1H2AI; H2AC15 H2AFD HIST1H2AK; H2AC16 H2AFI HIST1H2AL; H2AC17 H2AFN HIST1H2AM	Homo sapiens (Human)	130	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.			extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P0C1S8	reviewed	WEE2_HUMAN	Wee1-like protein kinase 2 (EC 2.7.10.2) (Wee1-like protein kinase 1B) (Wee1B kinase)	WEE2 WEE1B	Homo sapiens (Human)	567	FUNCTION: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity). {ECO:0000250|UniProtKB:Q66JT0, ECO:0000269|PubMed:29606300}.		female meiotic nuclear division [GO:0007143]; female pronucleus assembly [GO:0035038]; mitotic cell cycle [GO:0000278]; negative regulation of oocyte maturation [GO:1900194]; phosphorylation [GO:0016310]; positive regulation of phosphorylation [GO:0042327]; regulation of fertilization [GO:0080154]; regulation of meiosis I [GO:0060631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; female meiotic nuclear division [GO:0007143]; female pronucleus assembly [GO:0035038]; mitotic cell cycle [GO:0000278]; negative regulation of oocyte maturation [GO:1900194]; phosphorylation [GO:0016310]; positive regulation of phosphorylation [GO:0042327]; regulation of fertilization [GO:0080154]; regulation of meiosis I [GO:0060631]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11029659, ECO:0000269|PubMed:29606300}.
P0C1Z6	reviewed	TFPT_HUMAN	TCF3 fusion partner (INO80 complex subunit F) (Protein FB1)	TFPT INO80F	Homo sapiens (Human)	253	FUNCTION: Appears to promote apoptosis in a p53/TP53-independent manner.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.		apoptotic signaling pathway [GO:0097190]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; male gonad development [GO:0008584]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; apoptotic signaling pathway [GO:0097190]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; male gonad development [GO:0008584]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18922472}.
P0C264	reviewed	SBK3_HUMAN	Uncharacterized serine/threonine-protein kinase SBK3 (EC 2.7.11.1) (SH3 domain-binding kinase family member 3) (Sugen kinase 110)	SBK3 SGK110	Homo sapiens (Human)	359			phosphorylation [GO:0016310]		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	
P0C2W1	reviewed	FBSP1_HUMAN	F-box/SPRY domain-containing protein 1 (F-box only protein 45) (hFbxo45)	FBXO45 FBX45	Homo sapiens (Human)	286	FUNCTION: Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1 (PubMed:29997255). Functions in substrate recognition but plays also an important role in assembly of the complex (PubMed:29997255). Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Regulates neuron migration during brain development through interaction with N-cadherin/CDH2 after secretion via a non-classical mechanism (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. Polyubiquitinates NMNAT2, an adenylyltransferase that acts as an axon maintenance factor, and regulates its stability and degradation by the proteasome (PubMed:29997255). Acts also by ubiquitinating FBXW7 during prolonged mitotic arrest and promotes FBXW7 proteasomal degradation (PubMed:31285543). Induces subsequently an increase in mitotic slippage and prevents mitotic cell death (PubMed:31285543). In response to influenza infection, mediates interferon-lambda receptor IFNLR1 polyubiquitination and degradation through the ubiquitin-proteasome system by docking with its intracellular receptor domain (PubMed:36379255). {ECO:0000250|UniProtKB:P0CH38, ECO:0000250|UniProtKB:Q8K3B1, ECO:0000269|PubMed:19581926, ECO:0000269|PubMed:29997255, ECO:0000269|PubMed:31285543, ECO:0000269|PubMed:36379255}.		anterior commissure morphogenesis [GO:0021960]; cerebral cortex radially oriented cell migration [GO:0021799]; cerebral cortex tangential migration [GO:0021800]; corticospinal tract morphogenesis [GO:0021957]; DNA damage response [GO:0006974]; neuron migration [GO:0001764]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of synaptic vesicle exocytosis [GO:2000300]; synapse assembly involved in innervation [GO:0060386]; ubiquitin-dependent protein catabolic process [GO:0006511]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic cytosol [GO:0099523]; presynaptic membrane [GO:0042734]; SCF ubiquitin ligase complex [GO:0019005]; synapse [GO:0045202]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic cytosol [GO:0099523]; presynaptic membrane [GO:0042734]; SCF ubiquitin ligase complex [GO:0019005]; synapse [GO:0045202]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; anterior commissure morphogenesis [GO:0021960]; cerebral cortex radially oriented cell migration [GO:0021799]; cerebral cortex tangential migration [GO:0021800]; corticospinal tract morphogenesis [GO:0021957]; DNA damage response [GO:0006974]; neuron migration [GO:0001764]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of synaptic vesicle exocytosis [GO:2000300]; synapse assembly involved in innervation [GO:0060386]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32341084}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P0CH38}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P0CH38}. Nucleus {ECO:0000269|PubMed:26068074}. Note=Secreted by a non-classical mechanism. {ECO:0000269|PubMed:32341084}.
P0C5Y9	reviewed	H2AB1_HUMAN	Histone H2A-Bbd type 1 (H2A Barr body-deficient) (H2A.B) (H2A.Bbd)	H2AB1 H2AFB1	Homo sapiens (Human)	115	FUNCTION: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PubMed:17591702, PubMed:24753410). They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134). {ECO:0000269|PubMed:15257289, ECO:0000269|PubMed:16287874, ECO:0000269|PubMed:16957777, ECO:0000269|PubMed:17591702, ECO:0000269|PubMed:17726088, ECO:0000269|PubMed:18329190, ECO:0000269|PubMed:22795134, ECO:0000269|PubMed:24336483, ECO:0000269|PubMed:24753410}.	MISCELLANEOUS: In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications. {ECO:0000305}.	mRNA processing [GO:0006397]; nucleosome assembly [GO:0006334]	euchromatin [GO:0000791]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	euchromatin [GO:0000791]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; mRNA processing [GO:0006397]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20008104, ECO:0000269|PubMed:24336483}. Chromosome {ECO:0000269|PubMed:20008104, ECO:0000269|PubMed:22795134, ECO:0000269|PubMed:24336483}. Note=Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies. {ECO:0000269|PubMed:20008104}.
P0C5Z0	reviewed	H2AB2_HUMAN	Histone H2A-Bbd type 2/3 (H2A Barr body-deficient) (H2A.Bbd)	H2AB2 H2AFB2; H2AB3 H2ABBD H2AFB H2AFB3	Homo sapiens (Human)	115	FUNCTION: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis. {ECO:0000269|PubMed:15257289, ECO:0000269|PubMed:16287874, ECO:0000269|PubMed:16957777, ECO:0000269|PubMed:17591702, ECO:0000269|PubMed:17726088, ECO:0000269|PubMed:18329190, ECO:0000269|PubMed:22795134}.	MISCELLANEOUS: In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications.	mRNA processing [GO:0006397]; nucleosome assembly [GO:0006334]	euchromatin [GO:0000791]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	euchromatin [GO:0000791]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; mRNA processing [GO:0006397]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20008104}. Chromosome {ECO:0000269|PubMed:20008104, ECO:0000269|PubMed:22795134}. Note=Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies. {ECO:0000269|PubMed:20008104}.
P0C7P0	reviewed	CISD3_HUMAN	CDGSH iron-sulfur domain-containing protein 3, mitochondrial (MitoNEET-related protein 2) (Miner2) (Mitochondrial inner NEET protein) (MiNT)	CISD3	Homo sapiens (Human)	127	FUNCTION: Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function. {ECO:0000269|PubMed:29259115}.		protein maturation by [2Fe-2S] cluster transfer [GO:0106034]	mitochondrion [GO:0005739]	2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]	mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; protein maturation by [2Fe-2S] cluster transfer [GO:0106034]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:17376863}.
P0C7P3	reviewed	SLN14_HUMAN	Protein SLFN14 [Cleaved into: C-terminally truncated SLFN14 endoribonuclease (EC 3.1.-.-) (Schlafen family member 14)]	SLFN14	Homo sapiens (Human)	912	FUNCTION: [Protein SLFN14]: Shows no ribosome-associated and endoribonuclease activities. {ECO:0000269|PubMed:25996083}.; FUNCTION: [C-terminally truncated SLFN14 endoribonuclease]: Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension. {ECO:0000250|UniProtKB:G1SRW8, ECO:0000269|PubMed:25996083, ECO:0000269|PubMed:26769223, ECO:0000305|PubMed:25996083}.		cellular response to magnesium ion [GO:0071286]; cellular response to manganese ion [GO:0071287]; mRNA catabolic process [GO:0006402]; platelet maturation [GO:0036345]; rRNA catabolic process [GO:0016075]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ribosome binding [GO:0043022]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ribosome binding [GO:0043022]; RNA endonuclease activity [GO:0004521]; cellular response to magnesium ion [GO:0071286]; cellular response to manganese ion [GO:0071287]; mRNA catabolic process [GO:0006402]; platelet maturation [GO:0036345]; rRNA catabolic process [GO:0016075]	SUBCELLULAR LOCATION: [Protein SLFN14]: Nucleus {ECO:0000269|PubMed:25996083, ECO:0000269|PubMed:26280575}.
P0C7T5	reviewed	ATX1L_HUMAN	Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1)	ATXN1L BOAT BOAT1	Homo sapiens (Human)	689	FUNCTION: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}.		anatomical structure development [GO:0048856]; brain development [GO:0007420]; extracellular matrix organization [GO:0030198]; learning [GO:0007612]; lung alveolus development [GO:0048286]; memory [GO:0007613]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; regulation of DNA-templated transcription [GO:0006355]; social behavior [GO:0035176]; transcription by RNA polymerase II [GO:0006366]	dendrite [GO:0030425]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; RNA binding [GO:0003723]	dendrite [GO:0030425]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; anatomical structure development [GO:0048856]; brain development [GO:0007420]; extracellular matrix organization [GO:0030198]; learning [GO:0007612]; lung alveolus development [GO:0048286]; memory [GO:0007613]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; regulation of DNA-templated transcription [GO:0006355]; social behavior [GO:0035176]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16121196}. Cell projection, dendrite {ECO:0000269|PubMed:16121196}. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
P0C7W6	reviewed	CC172_HUMAN	Coiled-coil domain-containing protein 172	CCDC172 C10orf96	Homo sapiens (Human)	258				cytoplasm [GO:0005737]; sperm midpiece [GO:0097225]		cytoplasm [GO:0005737]; sperm midpiece [GO:0097225]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q810N9}. Cell projection, cilium {ECO:0000250|UniProtKB:Q6AXT4}. Note=In spermatozoa, localized in the middle piece, predominantly concentrated at the mitochondrial sheath of the flagella and to a lesser extent with outer dense fibers (ODF) (By similarity). Colocalized with TEKT2 at the perinuclear region (By similarity). {ECO:0000250|UniProtKB:Q6AXT4, ECO:0000250|UniProtKB:Q810N9}.
P0C7X2	reviewed	ZN688_HUMAN	Zinc finger protein 688	ZNF688	Homo sapiens (Human)	276	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P0C869	reviewed	PA24B_HUMAN	Cytosolic phospholipase A2 beta (cPLA2-beta) (EC 3.1.1.4) (Lysophospholipase A1 group IVB) (EC 3.1.1.5) (Phospholipase A2 group IVB)	PLA2G4B	Homo sapiens (Human)	781	FUNCTION: Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059}.; FUNCTION: [Isoform 3]: Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines. {ECO:0000269|PubMed:16617059}.; FUNCTION: [Isoform 5]: Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059}.	MISCELLANEOUS: [Isoform 2]: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein. {ECO:0000305}.	arachidonic acid metabolic process [GO:0019369]; calcium-mediated signaling [GO:0019722]; glycerophospholipid catabolic process [GO:0046475]; inflammatory response [GO:0006954]; parturition [GO:0007567]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]; arachidonic acid metabolic process [GO:0019369]; calcium-mediated signaling [GO:0019722]; glycerophospholipid catabolic process [GO:0046475]; inflammatory response [GO:0006954]; parturition [GO:0007567]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]	SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol {ECO:0000269|PubMed:16617059}. Mitochondrion membrane {ECO:0000269|PubMed:16617059}; Peripheral membrane protein. Early endosome membrane {ECO:0000269|PubMed:16617059}; Peripheral membrane protein. Note=Translocates to membrane vesicles in a calcium-dependent fashion. {ECO:0000269|PubMed:16617059}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm, cytosol {ECO:0000269|PubMed:16617059}.
P0C870	reviewed	JMJD7_HUMAN	Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 (EC 1.14.11.63) (EC 3.4.-.-) (JmjC domain-containing protein 7) (Jumonji domain-containing protein 7) (L-lysine (3S)-hydroxylase JMJD7)	JMJD7	Homo sapiens (Human)	316	FUNCTION: Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (PubMed:28847961, PubMed:29915238). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4 (PubMed:28847961). After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery (PubMed:29915238). Acts as Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (PubMed:29915238). {ECO:0000269|PubMed:28847961, ECO:0000269|PubMed:29915238}.		protein hydroxylation [GO:0018126]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; monooxygenase activity [GO:0004497]; peptidyl-lysine 3-dioxygenase activity [GO:0106155]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; monooxygenase activity [GO:0004497]; peptidyl-lysine 3-dioxygenase activity [GO:0106155]; protein hydroxylation [GO:0018126]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29915238}. Cytoplasm {ECO:0000269|PubMed:29915238}.
P0CAP1	reviewed	MYZAP_HUMAN	Myocardial zonula adherens protein (GRINL1A upstream protein) (Gup)	MYZAP MYOZAP	Homo sapiens (Human)	466	FUNCTION: Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). {ECO:0000250}.	MISCELLANEOUS: The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene.; MISCELLANEOUS: [Isoform 11]: Based on a naturally occurring readthrough transcript which produces a MYZAP-POLR2M fusion protein. {ECO:0000305}.	intracellular signal transduction [GO:0035556]; maintenance of ER location [GO:0051685]	anchoring junction [GO:0070161]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic side of plasma membrane [GO:0009898]; I band [GO:0031674]; nuclear envelope [GO:0005635]; RNA polymerase II, holoenzyme [GO:0016591]; Z disc [GO:0030018]		anchoring junction [GO:0070161]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic side of plasma membrane [GO:0009898]; I band [GO:0031674]; nuclear envelope [GO:0005635]; RNA polymerase II, holoenzyme [GO:0016591]; Z disc [GO:0030018]; intracellular signal transduction [GO:0035556]; maintenance of ER location [GO:0051685]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5EB94}. Cell membrane {ECO:0000250|UniProtKB:Q5EB94}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q5EB94}; Cytoplasmic side {ECO:0000250|UniProtKB:Q5EB94}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:Q5EB94}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q5EB94}. Cell junction {ECO:0000269|PubMed:18849881, ECO:0000269|PubMed:21240187}. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin. {ECO:0000250|UniProtKB:Q5EB94}.
P0CAP2	reviewed	GRL1A_HUMAN	DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A)	POLR2M GRINL1A	Homo sapiens (Human)	368	FUNCTION: Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269|PubMed:16769904}.	MISCELLANEOUS: The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene.	intracellular signal transduction [GO:0035556]; maintenance of ER location [GO:0051685]; transcription elongation by RNA polymerase II [GO:0006368]	I band [GO:0031674]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase II, holoenzyme [GO:0016591]; transcription preinitiation complex [GO:0097550]	transcription elongation factor activity [GO:0003711]	I band [GO:0031674]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase II, holoenzyme [GO:0016591]; transcription preinitiation complex [GO:0097550]; transcription elongation factor activity [GO:0003711]; intracellular signal transduction [GO:0035556]; maintenance of ER location [GO:0051685]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000305}.
P0CB47	reviewed	UBFL1_HUMAN	Upstream-binding factor 1-like protein 1	UBTFL1 C11orf27	Homo sapiens (Human)	393	FUNCTION: Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development. {ECO:0000250|UniProtKB:Q3USZ2}.		blastocyst growth [GO:0001832]; embryo implantation [GO:0007566]; positive regulation of transcription by RNA polymerase I [GO:0045943]; transcription by RNA polymerase I [GO:0006360]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; blastocyst growth [GO:0001832]; embryo implantation [GO:0007566]; positive regulation of transcription by RNA polymerase I [GO:0045943]; transcription by RNA polymerase I [GO:0006360]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3USZ2}. Nucleus {ECO:0000250|UniProtKB:Q3USZ2, ECO:0000255|PROSITE-ProRule:PRU00267}. Note=Mainly cytoplasmic from the 4-cell stage to the morula stage. Becomes nuclear at the blastocyst stage. {ECO:0000250|UniProtKB:Q3USZ2}.
P0CG04	reviewed	IGLC1_HUMAN	Immunoglobulin lambda constant 1 (Ig lambda chain C region MGC) (Ig lambda-1 chain C region)	IGLC1	Homo sapiens (Human)	106	FUNCTION: Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.		adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgD immunoglobulin complex [GO:0071738]; IgE immunoglobulin complex [GO:0071742]; IgG immunoglobulin complex [GO:0071735]; IgM immunoglobulin complex [GO:0071753]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgD immunoglobulin complex [GO:0071738]; IgE immunoglobulin complex [GO:0071742]; IgG immunoglobulin complex [GO:0071735]; IgM immunoglobulin complex [GO:0071753]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0CG20	reviewed	PRR35_HUMAN	Proline-rich protein 35 (Uncharacterized protein RJD1)	PRR35 C16orf11	Homo sapiens (Human)	571							
P0CG30	reviewed	GSTT2_HUMAN	Glutathione S-transferase theta-2B (EC 2.5.1.18) (Glutathione S-transferase theta-2) (GST class-theta-2)	GSTT2B GSTT2	Homo sapiens (Human)	244	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:1417752). Has a sulfatase activity (PubMed:1417752). {ECO:0000269|PubMed:1417752}.		glutathione metabolic process [GO:0006749]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	glutathione transferase activity [GO:0004364]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutathione transferase activity [GO:0004364]; glutathione metabolic process [GO:0006749]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1417752}.
P0CG37	reviewed	CFC1_HUMAN	Cryptic protein (Cryptic family protein 1)	CFC1	Homo sapiens (Human)	223	FUNCTION: NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation. {ECO:0000269|PubMed:11062482}.		anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; determination of left/right symmetry [GO:0007368]; gastrulation [GO:0007369]; heart development [GO:0007507]; nodal signaling pathway [GO:0038092]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	activin receptor binding [GO:0070697]; nodal binding [GO:0038100]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; activin receptor binding [GO:0070697]; nodal binding [GO:0038100]; anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; determination of left/right symmetry [GO:0007368]; gastrulation [GO:0007369]; heart development [GO:0007507]; nodal signaling pathway [GO:0038092]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18930707}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18930707}. Secreted {ECO:0000269|PubMed:18930707}. Note=Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI-signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates.
P0CG47	reviewed	UBB_HUMAN	Polyubiquitin-B [Cleaved into: Ubiquitin]	UBB	Homo sapiens (Human)	229	FUNCTION: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.	MISCELLANEOUS: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.; MISCELLANEOUS: The mRNA encoding variant UBB(+1) is produced by an unknown mechanism involving the deletion of a GT dinucleotide in the close proximity of a GAGAG motif (PubMed:9422699). This variant mRNA is found in normal brain, but the encoded protein accumulates only in brain neurofibrillary tangles and neuritic plaques in Alzheimer disease and other tauopathies, as well as polyglutaminopathies (PubMed:14597671). UBB(+1) variant cannot be used for polyubiquitination, is not effectively degraded by the proteasome when ubiquitinated and ubiquitinated UBB(+1) is refractory to disassembly by deubiquitinating enzymes (DUBs). In healthy brain, UBB(+1) C-terminus can be cleaved by UCHL3 (PubMed:21762696). {ECO:0000305|PubMed:14597671, ECO:0000305|PubMed:21762696, ECO:0000305|PubMed:9422699}.; MISCELLANEOUS: For a better understanding, features related to ubiquitin are only indicated for the first chain.	energy homeostasis [GO:0097009]; fat pad development [GO:0060613]; female gonad development [GO:0008585]; female meiosis I [GO:0007144]; hypothalamus gonadotrophin-releasing hormone neuron development [GO:0021888]; male meiosis I [GO:0007141]; mitochondrion transport along microtubule [GO:0047497]; modification-dependent protein catabolic process [GO:0019941]; neuron projection morphogenesis [GO:0048812]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of protein monoubiquitination [GO:1902527]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of neuron apoptotic process [GO:0043523]; regulation of proteasomal protein catabolic process [GO:0061136]; seminiferous tubule development [GO:0072520]	cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	protein tag activity [GO:0031386]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; protein tag activity [GO:0031386]; ubiquitin protein ligase binding [GO:0031625]; energy homeostasis [GO:0097009]; fat pad development [GO:0060613]; female gonad development [GO:0008585]; female meiosis I [GO:0007144]; hypothalamus gonadotrophin-releasing hormone neuron development [GO:0021888]; male meiosis I [GO:0007141]; mitochondrion transport along microtubule [GO:0047497]; modification-dependent protein catabolic process [GO:0019941]; neuron projection morphogenesis [GO:0048812]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of protein monoubiquitination [GO:1902527]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of neuron apoptotic process [GO:0043523]; regulation of proteasomal protein catabolic process [GO:0061136]; seminiferous tubule development [GO:0072520]	SUBCELLULAR LOCATION: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion outer membrane {ECO:0000269|PubMed:24751536}; Peripheral membrane protein {ECO:0000305|PubMed:24751536}.
P0CG48	reviewed	UBC_HUMAN	Polyubiquitin-C [Cleaved into: Ubiquitin]	UBC	Homo sapiens (Human)	685	FUNCTION: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.	MISCELLANEOUS: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.; MISCELLANEOUS: For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.	modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	protease binding [GO:0002020]; protein tag activity [GO:0031386]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; protease binding [GO:0002020]; protein tag activity [GO:0031386]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion outer membrane {ECO:0000269|PubMed:24751536}; Peripheral membrane protein {ECO:0000305|PubMed:24751536}.
P0CW18	reviewed	PRS56_HUMAN	Serine protease 56 (EC 3.4.21.-)	PRSS56	Homo sapiens (Human)	603	FUNCTION: Serine protease required during eye development. {ECO:0000269|PubMed:21397065}.		blood coagulation [GO:0007596]; camera-type eye development [GO:0043010]; positive regulation of leukocyte chemotaxis [GO:0002690]; proteolysis [GO:0006508]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; blood coagulation [GO:0007596]; camera-type eye development [GO:0043010]; positive regulation of leukocyte chemotaxis [GO:0002690]; proteolysis [GO:0006508]	
P0DI81	reviewed	TPC2A_HUMAN	Trafficking protein particle complex subunit 2 (Sedlin)	TRAPPC2 SEDL	Homo sapiens (Human)	140	FUNCTION: Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000250}.	MISCELLANEOUS: A paralogous gene encoding an identical protein appears to have arisen by retrotransposition of a cDNA from this locus and to have acquired a promoter and non-coding 5' UTR from the ZNF547 gene.	COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; skeletal system development [GO:0001501]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]	transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]; transmembrane transporter binding [GO:0044325]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; skeletal system development [GO:0001501]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11031107}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:11031107}. Nucleus {ECO:0000269|PubMed:20498720, ECO:0000269|PubMed:25918224}. Cytoplasm {ECO:0000269|PubMed:20498720}. Note=Localized in perinuclear granular structures. {ECO:0000269|PubMed:11031107}.
P0DI82	reviewed	TPC2B_HUMAN	Trafficking protein particle complex subunit 2B (MBP-1-interacting protein 2A) (MIP-2A)	TRAPPC2B SEDLP1 TRAPPC2.19 TRAPPC2P1	Homo sapiens (Human)	140	FUNCTION: Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000269|PubMed:11134351}.	MISCELLANEOUS: The gene encoding this protein appears to have arisen by retrotransposition of a cDNA from the X-linked locus TRAPPC2. The site of integration of this retrotransposed cDNA appears to lie within an intron of the ZNF547 gene, which provides a promoter and non-coding 5' exon. TRAPPC2 and this protein are indistinguishable at protein level, and both proteins have been identified and functionally characterized.	COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of gene expression [GO:0010628]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; intracellular membrane-bounded organelle [GO:0043231]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]	transcription corepressor binding [GO:0001222]; transcription regulator inhibitor activity [GO:0140416]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; intracellular membrane-bounded organelle [GO:0043231]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]; transcription corepressor binding [GO:0001222]; transcription regulator inhibitor activity [GO:0140416]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of gene expression [GO:0010628]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0DI81}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11134351}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:P0DI81}. Cytoplasm {ECO:0000250|UniProtKB:P0DI81}. Note=Localized in perinuclear granular structures. {ECO:0000250|UniProtKB:P0DI81}.
P0DI83	reviewed	NARR_HUMAN	Ras-related protein Rab-34, isoform NARR (Nine amino-acid residue-repeats)	RAB34 NARR	Homo sapiens (Human)	198				nucleolus [GO:0005730]		nucleolus [GO:0005730]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21586586}. Nucleus, nucleolus {ECO:0000269|PubMed:21586586}. Note=Colocalizes with rDNA clusters.
P0DJD3	reviewed	RBY1A_HUMAN	RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY)	RBMY1A1 RBM1 RBM2 YRRM1 YRRM2	Homo sapiens (Human)	496	FUNCTION: RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:8269511}.	MISCELLANEOUS: The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.	mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9108067}.
P0DJD4	reviewed	RBY1C_HUMAN	RNA-binding motif protein, Y chromosome, family 1 member C	RBMY1C	Homo sapiens (Human)	496	FUNCTION: RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.	MISCELLANEOUS: The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.	mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9108067}.
P0DJD7	reviewed	PEPA4_HUMAN	Pepsin A-4 (EC 3.4.23.1) (Pepsinogen-4)	PGA4	Homo sapiens (Human)	388	FUNCTION: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.		digestion [GO:0007586]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; multivesicular body lumen [GO:0097486]	aspartic-type endopeptidase activity [GO:0004190]	extracellular exosome [GO:0070062]; multivesicular body lumen [GO:0097486]; aspartic-type endopeptidase activity [GO:0004190]; digestion [GO:0007586]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
P0DJD8	reviewed	PEPA3_HUMAN	Pepsin A-3 (EC 3.4.23.1) (Pepsinogen-3)	PGA3	Homo sapiens (Human)	388	FUNCTION: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.		digestion [GO:0007586]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; multivesicular body lumen [GO:0097486]	aspartic-type endopeptidase activity [GO:0004190]	extracellular exosome [GO:0070062]; multivesicular body lumen [GO:0097486]; aspartic-type endopeptidase activity [GO:0004190]; digestion [GO:0007586]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
P0DJD9	reviewed	PEPA5_HUMAN	Pepsin A-5 (EC 3.4.23.1) (Pepsinogen-5)	PGA5	Homo sapiens (Human)	388	FUNCTION: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.		digestion [GO:0007586]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; multivesicular body lumen [GO:0097486]	aspartic-type endopeptidase activity [GO:0004190]	extracellular exosome [GO:0070062]; multivesicular body lumen [GO:0097486]; aspartic-type endopeptidase activity [GO:0004190]; digestion [GO:0007586]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
P0DJI8	reviewed	SAA1_HUMAN	Serum amyloid A-1 protein (SAA) [Cleaved into: Amyloid protein A (Amyloid fibril protein AA); Serum amyloid protein A(2-104); Serum amyloid protein A(3-104); Serum amyloid protein A(2-103); Serum amyloid protein A(2-102); Serum amyloid protein A(4-101)]	SAA1	Homo sapiens (Human)	122	FUNCTION: Major acute phase protein.		acute-phase response [GO:0006953]; lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; negative regulation of inflammatory response [GO:0050728]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of interleukin-1 production [GO:0032732]; regulation of protein secretion [GO:0050708]	cytoplasmic microtubule [GO:0005881]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]	G protein-coupled receptor binding [GO:0001664]; heparin binding [GO:0008201]	cytoplasmic microtubule [GO:0005881]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; G protein-coupled receptor binding [GO:0001664]; heparin binding [GO:0008201]; acute-phase response [GO:0006953]; lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; negative regulation of inflammatory response [GO:0050728]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of interleukin-1 production [GO:0032732]; regulation of protein secretion [GO:0050708]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7115671}.
P0DJI9	reviewed	SAA2_HUMAN	Serum amyloid A-2 protein (SAA2) [Cleaved into: Amyloid A2 protein (AA2)]	SAA2	Homo sapiens (Human)	122	FUNCTION: Major acute phase reactant. {ECO:0000250|UniProtKB:P05366}.		acute-phase response [GO:0006953]	extracellular exosome [GO:0070062]; high-density lipoprotein particle [GO:0034364]		extracellular exosome [GO:0070062]; high-density lipoprotein particle [GO:0034364]; acute-phase response [GO:0006953]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0DJI8}.
P0DJJ0	reviewed	SRG2C_HUMAN	SLIT-ROBO Rho GTPase-activating protein 2C (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1)	SRGAP2C SRGAP2P1	Homo sapiens (Human)	459	FUNCTION: Human-specific protein that acts as a key modifier of cortical connectivity in the human brain (PubMed:22559944, PubMed:27373832, PubMed:34707291). Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation (PubMed:27373832, PubMed:28333212, PubMed:31822692). Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to an increase in synaptic density and protracted synaptic maturation of both excitatory and inhibitory synapses (PubMed:27373832, PubMed:34707291). Modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons (PubMed:34707291). Also able to increase the probability of sensory-evoked responses by layer 2/3 pyramidal neurons (PubMed:34707291). {ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212, ECO:0000269|PubMed:31822692, ECO:0000269|PubMed:34707291}.	MISCELLANEOUS: This is one of the 3 duplications of the ancestral gene SRGAP2/SRGAP2A which has undergone human-specific segmental gene duplications (PubMed:22559944, PubMed:22559943). The appearance of SRGAP2C in the human genome is estimated to 2,4 million years and corresponds to the beginning of neocortex expansion in human evolution (PubMed:22559944, PubMed:22559943, PubMed:34707291). The emergence of SRGAP2C at the birth of the Homo lineage probably contributed to the evolution of specific structural and functional features of cortical circuits in the human cortex (PubMed:34707291). {ECO:0000269|PubMed:22559943, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:34707291}.; MISCELLANEOUS: Expression of SRGAP2C in mouse cortical pyramidal neurons leads to the emergence of human-specific traits of synaptic development, characterized by increases in the density of both excitatory and inhibitory synapses received by layer 2/3 pyramidal neurons and neotenic features of excitatory and inhibitory synaptic development (PubMed:22559944, PubMed:27373832, PubMed:34707291). Mice humanized for SRGAP2C expression in all cortical pyramidal neurons show a shift in the fraction of layer 2/3 pyramidal neurons activated by sensory stimulation and an enhanced ability to learn a cortex-dependent sensory-discrimination task (PubMed:34707291). {ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:34707291}.	cerebral cortex development [GO:0021987]; excitatory synapse assembly [GO:1904861]; extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [GO:0021816]; inhibitory synapse assembly [GO:1904862]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of filopodium assembly [GO:0051490]; positive regulation of neuron migration [GO:2001224]		protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; cerebral cortex development [GO:0021987]; excitatory synapse assembly [GO:1904861]; extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [GO:0021816]; inhibitory synapse assembly [GO:1904862]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of filopodium assembly [GO:0051490]; positive regulation of neuron migration [GO:2001224]	
P0DMC3	reviewed	ELA_HUMAN	Apelin receptor early endogenous ligand (Protein Elabela) (ELA) (Protein Toddler)	APELA ELA TDL	Homo sapiens (Human)	54	FUNCTION: Endogenous ligand for the apelin receptor (APLNR) (PubMed:25639753, PubMed:28137936). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis (PubMed:25639753, PubMed:28137936). Drives internalization of APLNR. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating APLNR. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Plays a role in placental vascular development; promotes placental trophoblast invasion and spiral artery remodeling in the uterus. Involved in the regulation of maternal cardiovascular homeostasis to prevent gestational hypertension and for potent cardioprotective functions during heart failure. Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). {ECO:0000250|UniProtKB:P0DMC2, ECO:0000250|UniProtKB:P0DMC4, ECO:0000250|UniProtKB:P0DP76, ECO:0000269|PubMed:25639753, ECO:0000269|PubMed:28137936}.		adult heart development [GO:0007512]; angiogenesis [GO:0001525]; apelin receptor signaling pathway [GO:0060183]; cell migration involved in mesendoderm migration [GO:0090134]; coronary vasculature development [GO:0060976]; embryonic heart tube development [GO:0035050]; endoderm development [GO:0007492]; heart development [GO:0007507]; mesendoderm migration [GO:0090133]; mesoderm migration involved in gastrulation [GO:0007509]; placenta blood vessel development [GO:0060674]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor internalization [GO:1904022]; positive regulation of heart contraction [GO:0045823]; positive regulation of trophoblast cell migration [GO:1901165]; vasculogenesis [GO:0001570]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	apelin receptor binding [GO:0031704]; hormone activity [GO:0005179]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; apelin receptor binding [GO:0031704]; hormone activity [GO:0005179]; adult heart development [GO:0007512]; angiogenesis [GO:0001525]; apelin receptor signaling pathway [GO:0060183]; cell migration involved in mesendoderm migration [GO:0090134]; coronary vasculature development [GO:0060976]; embryonic heart tube development [GO:0035050]; endoderm development [GO:0007492]; heart development [GO:0007507]; mesendoderm migration [GO:0090133]; mesoderm migration involved in gastrulation [GO:0007509]; placenta blood vessel development [GO:0060674]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor internalization [GO:1904022]; positive regulation of heart contraction [GO:0045823]; positive regulation of trophoblast cell migration [GO:1901165]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24316148, ECO:0000269|PubMed:28137936}. Secreted, extracellular space {ECO:0000269|PubMed:28137936}. Note=Found in blood plasma (PubMed:28137936). Found in serum of pregnant mice, peaking at midgestation; indicating a maternal and zygotic origin of circulating APELA during pregnancy (By similarity). {ECO:0000250|UniProtKB:P0DMC4}.
P0DME0	reviewed	SETLP_HUMAN	Protein SETSIP (SET pseudogene protein 18) (SET similar protein) (Similar to SET translocation protein)	SETSIP SETP18	Homo sapiens (Human)	302	FUNCTION: Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter. {ECO:0000269|PubMed:22869753}.	MISCELLANEOUS: Probable retrogene derived from SET transcript.	endothelial cell differentiation [GO:0045446]; nucleosome assembly [GO:0006334]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; endothelial cell differentiation [GO:0045446]; nucleosome assembly [GO:0006334]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22869753}. Nucleus {ECO:0000269|PubMed:22869753}. Note=Translocated from the cytoplasm to the nucleus in protein-induced pluripotent stem (PiPS) endothelial cells.
P0DML2	reviewed	CSH1_HUMAN	Chorionic somatomammotropin hormone 1 (Choriomammotropin) (Lactogen) (Placental lactogen) (PL)	CSH1	Homo sapiens (Human)	217	FUNCTION: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. {ECO:0000269|PubMed:16546209}.	MISCELLANEOUS: CSH1 sequence only differs from CSH2 sequence in 1 aa.	animal organ development [GO:0048513]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of growth [GO:0045927]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to nutrient levels [GO:0031667]	endoplasmic reticulum [GO:0005783]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; vesicle [GO:0031982]	growth factor activity [GO:0008083]; growth hormone receptor binding [GO:0005131]; hormone activity [GO:0005179]; metal ion binding [GO:0046872]	endoplasmic reticulum [GO:0005783]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; vesicle [GO:0031982]; growth factor activity [GO:0008083]; growth hormone receptor binding [GO:0005131]; hormone activity [GO:0005179]; metal ion binding [GO:0046872]; animal organ development [GO:0048513]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of growth [GO:0045927]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to nutrient levels [GO:0031667]	SUBCELLULAR LOCATION: Secreted.
P0DML3	reviewed	CSH2_HUMAN	Chorionic somatomammotropin hormone 2 (Choriomammotropin) (Lactogen) (Placental lactogen) (PL)	CSH2	Homo sapiens (Human)	217	FUNCTION: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. {ECO:0000269|PubMed:16546209}.	MISCELLANEOUS: CSH2 sequence only differs from CSH1 sequence in 1 aa.	animal organ development [GO:0048513]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of growth [GO:0045927]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to nutrient levels [GO:0031667]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; vesicle [GO:0031982]	growth factor activity [GO:0008083]; growth hormone receptor binding [GO:0005131]; hormone activity [GO:0005179]; metal ion binding [GO:0046872]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; vesicle [GO:0031982]; growth factor activity [GO:0008083]; growth hormone receptor binding [GO:0005131]; hormone activity [GO:0005179]; metal ion binding [GO:0046872]; animal organ development [GO:0048513]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of growth [GO:0045927]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to nutrient levels [GO:0031667]	SUBCELLULAR LOCATION: Secreted.
P0DMM9	reviewed	ST1A3_HUMAN	Sulfotransferase 1A3 (ST1A3) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Catecholamine-sulfating phenol sulfotransferase) (HAST3) (M-PST) (Monoamine-sulfating phenol sulfotransferase) (Placental estrogen sulfotransferase) (Sulfotransferase 1A3/1A4) (Sulfotransferase, monoamine-preferring) (Thermolabile phenol sulfotransferase) (TL-PST)	SULT1A3 STM	Homo sapiens (Human)	295	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs. {ECO:0000269|PubMed:15358107, ECO:0000269|PubMed:8093002}.		3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; cellular response to dopamine [GO:1903351]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	amine sulfotransferase activity [GO:0047685]; aryl sulfotransferase activity [GO:0004062]; sulfate binding [GO:0043199]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; amine sulfotransferase activity [GO:0047685]; aryl sulfotransferase activity [GO:0004062]; sulfate binding [GO:0043199]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; cellular response to dopamine [GO:1903351]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8093002}.
P0DMN0	reviewed	ST1A4_HUMAN	Sulfotransferase 1A4 (ST1A4) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Sulfotransferase 1A3/1A4)	SULT1A4	Homo sapiens (Human)	295	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.		catecholamine metabolic process [GO:0006584]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	aryl sulfotransferase activity [GO:0004062]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; catecholamine metabolic process [GO:0006584]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]	SUBCELLULAR LOCATION: Cytoplasm.
P0DMS8	reviewed	AA3R_HUMAN	Adenosine receptor A3	ADORA3	Homo sapiens (Human)	318	FUNCTION: [Isoform 2]: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:8234299). {ECO:0000269|PubMed:8234299}.		activation of adenylate cyclase activity [GO:0007190]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; inflammatory response [GO:0006954]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of heart contraction [GO:0008016]; regulation of norepinephrine secretion [GO:0014061]; response to wounding [GO:0009611]; signal transduction [GO:0007165]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]	G protein-coupled adenosine receptor activity [GO:0001609]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; G protein-coupled adenosine receptor activity [GO:0001609]; activation of adenylate cyclase activity [GO:0007190]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; inflammatory response [GO:0006954]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of heart contraction [GO:0008016]; regulation of norepinephrine secretion [GO:0014061]; response to wounding [GO:0009611]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q28309}; Multi-pass membrane protein {ECO:0000255}.
P0DMS9	reviewed	TMIG3_HUMAN	Transmembrane domain-containing protein TMIGD3	TMIGD3 UNQ1931/PRO4406	Homo sapiens (Human)	266	FUNCTION: [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186). {ECO:0000269|PubMed:27886186}.	MISCELLANEOUS: [Isoform 1]: The first exon of TMIGD3 isoform 1 (i1) is shared with the first exon of ADORA3 isoform 2 (A3AR i2, commonly known as A3AR), resulting in a fusion protein. {ECO:0000303|PubMed:27886186}.	activation of adenylate cyclase activity [GO:0007190]; inflammatory response [GO:0006954]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; regulation of heart contraction [GO:0008016]; response to wounding [GO:0009611]; signal transduction [GO:0007165]	membrane [GO:0016020]; plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; activation of adenylate cyclase activity [GO:0007190]; inflammatory response [GO:0006954]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; regulation of heart contraction [GO:0008016]; response to wounding [GO:0009611]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:27886186}; Multi-pass membrane protein {ECO:0000255}.
P0DMV8	reviewed	HS71A_HUMAN	Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1)	HSPA1A HSP72 HSPA1 HSX70	Homo sapiens (Human)	641	FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}.		ATP metabolic process [GO:0046034]; cellular heat acclimation [GO:0070370]; cellular response to heat [GO:0034605]; cellular response to oxidative stress [GO:0034599]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to unfolded protein [GO:0034620]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein complex assembly [GO:0051131]; lysosomal transport [GO:0007041]; mRNA catabolic process [GO:0006402]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of endoribonuclease activity [GO:1902380]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of RNA splicing [GO:0033120]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986]	aggresome [GO:0016235]; blood microparticle [GO:0072562]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; inclusion body [GO:0016234]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; vesicle [GO:0031982]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ATP-dependent protein folding chaperone [GO:0140662]; C3HC4-type RING finger domain binding [GO:0055131]; cadherin binding [GO:0045296]; death receptor agonist activity [GO:0038177]; denatured protein binding [GO:0031249]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; misfolded protein binding [GO:0051787]; protein folding chaperone [GO:0044183]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; virus receptor activity [GO:0001618]	aggresome [GO:0016235]; blood microparticle [GO:0072562]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; inclusion body [GO:0016234]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; vesicle [GO:0031982]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ATP-dependent protein folding chaperone [GO:0140662]; C3HC4-type RING finger domain binding [GO:0055131]; cadherin binding [GO:0045296]; death receptor agonist activity [GO:0038177]; denatured protein binding [GO:0031249]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; misfolded protein binding [GO:0051787]; protein folding chaperone [GO:0044183]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; virus receptor activity [GO:0001618]; ATP metabolic process [GO:0046034]; cellular heat acclimation [GO:0070370]; cellular response to heat [GO:0034605]; cellular response to oxidative stress [GO:0034599]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to unfolded protein [GO:0034620]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein complex assembly [GO:0051131]; lysosomal transport [GO:0007041]; mRNA catabolic process [GO:0006402]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of endoribonuclease activity [GO:1902380]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of RNA splicing [GO:0033120]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17289661}. Nucleus {ECO:0000269|PubMed:27137183}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27137183}. Secreted {ECO:0000250|UniProtKB:Q61696}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
P0DMV9	reviewed	HS71B_HUMAN	Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2)	HSPA1B HSP72	Homo sapiens (Human)	641	FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}.		ATP metabolic process [GO:0046034]; cellular heat acclimation [GO:0070370]; cellular response to heat [GO:0034605]; cellular response to oxidative stress [GO:0034599]; cellular response to steroid hormone stimulus [GO:0071383]; chaperone cofactor-dependent protein refolding [GO:0051085]; mRNA catabolic process [GO:0006402]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein ubiquitination [GO:0031396]	aggresome [GO:0016235]; blood microparticle [GO:0072562]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; inclusion body [GO:0016234]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; vesicle [GO:0031982]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ATP-dependent protein folding chaperone [GO:0140662]; C3HC4-type RING finger domain binding [GO:0055131]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; virus receptor activity [GO:0001618]	aggresome [GO:0016235]; blood microparticle [GO:0072562]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; inclusion body [GO:0016234]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; vesicle [GO:0031982]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ATP-dependent protein folding chaperone [GO:0140662]; C3HC4-type RING finger domain binding [GO:0055131]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; virus receptor activity [GO:0001618]; ATP metabolic process [GO:0046034]; cellular heat acclimation [GO:0070370]; cellular response to heat [GO:0034605]; cellular response to oxidative stress [GO:0034599]; cellular response to steroid hormone stimulus [GO:0071383]; chaperone cofactor-dependent protein refolding [GO:0051085]; mRNA catabolic process [GO:0006402]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein ubiquitination [GO:0031396]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17289661}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27137183}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
P0DMW2	reviewed	PYDC4_HUMAN	NLR family pyrin domain-containing protein 2B (Pyrin domain-containing protein 2-like protein POP4) (Pyrin-only protein 4)	NLRP2B CLRX.1 NLRP2P NOD24 POP4	Homo sapiens (Human)	45	FUNCTION: May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at 'Ser-536', thereby inhibiting its transcriptional activity. Through NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate immunity. May also play a role in cell cycle progression and apoptotic process. {ECO:0000269|PubMed:24871464}.		innate immune response [GO:0045087]; negative regulation of cell cycle [GO:0045786]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of apoptotic process [GO:0043065]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; innate immune response [GO:0045087]; negative regulation of cell cycle [GO:0045786]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24871464}. Nucleus {ECO:0000269|PubMed:24871464}. Note=Targeted to the nucleus upon TNF-alpha treatment. {ECO:0000269|PubMed:24871464}.
P0DN84	reviewed	DWORF_HUMAN	Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (SERCA regulator DWORF) (Dwarf open reading frame) (DWORF) (Small transmembrane regulator of ion transport 1)	STRIT1 DWORF	Homo sapiens (Human)	35	FUNCTION: Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN). {ECO:0000250|UniProtKB:P0DN83}.		positive regulation of calcium ion import into sarcoplasmic reticulum [GO:1902082]; regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901894]; regulation of slow-twitch skeletal muscle fiber contraction [GO:0031449]	sarcoplasmic reticulum membrane [GO:0033017]	enzyme activator activity [GO:0008047]	sarcoplasmic reticulum membrane [GO:0033017]; enzyme activator activity [GO:0008047]; positive regulation of calcium ion import into sarcoplasmic reticulum [GO:1902082]; regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901894]; regulation of slow-twitch skeletal muscle fiber contraction [GO:0031449]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P0DN83}; Single-pass membrane protein {ECO:0000255}.
P0DN86	reviewed	CGB3_HUMAN	Choriogonadotropin subunit beta 3 (Choriogonadotropin subunit beta) (CG-beta) (Chorionic gonadotropin chain beta)	CGB3 CGB; CGB5; CGB8	Homo sapiens (Human)	165	FUNCTION: Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. {ECO:0000305}.	MISCELLANEOUS: Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates. {ECO:0000269|PubMed:11861891}.	apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; female gamete generation [GO:0007292]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; pituitary gonadotropin complex [GO:0061696]	hormone activity [GO:0005179]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; pituitary gonadotropin complex [GO:0061696]; hormone activity [GO:0005179]; apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; female gamete generation [GO:0007292]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16123088}.
P0DOY2	reviewed	IGLC2_HUMAN	Immunoglobulin lambda constant 2 (Ig lambda chain C region Kern) (Ig lambda chain C region NIG-64) (Ig lambda chain C region SH) (Ig lambda chain C region X) (Ig lambda-2 chain C region)	IGLC2	Homo sapiens (Human)	106	FUNCTION: Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.	MISCELLANEOUS: Displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83. {ECO:0000303|Ref.12}.	immunoglobulin mediated immune response [GO:0016064]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgG immunoglobulin complex [GO:0071735]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgG immunoglobulin complex [GO:0071735]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DOY3	reviewed	IGLC3_HUMAN	Immunoglobulin lambda constant 3 (Ig lambda chain C region DOT) (Ig lambda chain C region NEWM) (Ig lambda-3 chain C regions)	IGLC3	Homo sapiens (Human)	106	FUNCTION: Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.	MISCELLANEOUS: Alleles IGLC3*01, IGLC3*02, and IGLC3*03 display the following serological isotype: Mcg-, Kern- and Oz+. The Mcg-isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz+ marker by Lys-83. Allele IGLC3*04 displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83. {ECO:0000303|Ref.10}.	adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immunoglobulin mediated immune response [GO:0016064]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgD immunoglobulin complex [GO:0071738]; IgE immunoglobulin complex [GO:0071742]; IgG immunoglobulin complex [GO:0071735]; IgM immunoglobulin complex [GO:0071753]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgD immunoglobulin complex [GO:0071738]; IgE immunoglobulin complex [GO:0071742]; IgG immunoglobulin complex [GO:0071735]; IgM immunoglobulin complex [GO:0071753]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DP23	reviewed	CALM1_HUMAN	Calmodulin-1	CALM1 CALM CAM CAM1	Homo sapiens (Human)	149	FUNCTION: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:23893133, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:26969752, ECO:0000269|PubMed:27165696, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:31454269, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity. {ECO:0000269|PubMed:31330532}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631}.	MISCELLANEOUS: This protein has four functional calcium-binding sites. {ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677}.	autophagosome membrane docking [GO:0016240]; cellular response to interferon-beta [GO:0035458]; cellular response to type II interferon [GO:0071346]; detection of calcium ion [GO:0005513]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; negative regulation of calcium ion export across plasma membrane [GO:1905913]; negative regulation of high voltage-gated calcium channel activity [GO:1901842]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; organelle localization by membrane tethering [GO:0140056]; positive regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051343]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytokinesis [GO:0032465]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; response to calcium ion [GO:0051592]; substantia nigra development [GO:0021762]	calcium channel complex [GO:0034704]; catalytic complex [GO:1902494]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; myelin sheath [GO:0043209]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076]	adenylate cyclase activator activity [GO:0010856]; calcium channel inhibitor activity [GO:0019855]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein kinase binding [GO:0019901]; protein phosphatase activator activity [GO:0072542]; protein serine/threonine kinase activator activity [GO:0043539]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325]	calcium channel complex [GO:0034704]; catalytic complex [GO:1902494]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; myelin sheath [GO:0043209]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076]; adenylate cyclase activator activity [GO:0010856]; calcium channel inhibitor activity [GO:0019855]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein kinase binding [GO:0019901]; protein phosphatase activator activity [GO:0072542]; protein serine/threonine kinase activator activity [GO:0043539]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325]; autophagosome membrane docking [GO:0016240]; cellular response to interferon-beta [GO:0035458]; cellular response to type II interferon [GO:0071346]; detection of calcium ion [GO:0005513]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; negative regulation of calcium ion export across plasma membrane [GO:1905913]; negative regulation of high voltage-gated calcium channel activity [GO:1901842]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; organelle localization by membrane tethering [GO:0140056]; positive regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051343]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytokinesis [GO:0032465]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; response to calcium ion [GO:0051592]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:P0DP26}. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
P0DP24	reviewed	CALM2_HUMAN	Calmodulin-2	CALM2 CAM2 CAMB	Homo sapiens (Human)	149	FUNCTION: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:26969752, PubMed:27165696). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:35568036, PubMed:26969752, PubMed:27165696). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:35568036, PubMed:26969752, PubMed:27165696). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:26969752, ECO:0000269|PubMed:27165696, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631}.	MISCELLANEOUS: This protein has four functional calcium-binding sites. {ECO:0000269|PubMed:1474585}.	detection of calcium ion [GO:0005513]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of calcium ion export across plasma membrane [GO:1905913]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051343]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytokinesis [GO:0032465]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to calcium ion [GO:0051592]; substantia nigra development [GO:0021762]	calcium channel complex [GO:0034704]; catalytic complex [GO:1902494]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; myelin sheath [GO:0043209]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076]	adenylate cyclase activator activity [GO:0010856]; adenylate cyclase binding [GO:0008179]; calcium channel inhibitor activity [GO:0019855]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein kinase binding [GO:0019901]; protein phosphatase activator activity [GO:0072542]; protein serine/threonine kinase activator activity [GO:0043539]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325]	calcium channel complex [GO:0034704]; catalytic complex [GO:1902494]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; myelin sheath [GO:0043209]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076]; adenylate cyclase activator activity [GO:0010856]; adenylate cyclase binding [GO:0008179]; calcium channel inhibitor activity [GO:0019855]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein kinase binding [GO:0019901]; protein phosphatase activator activity [GO:0072542]; protein serine/threonine kinase activator activity [GO:0043539]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325]; detection of calcium ion [GO:0005513]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of calcium ion export across plasma membrane [GO:1905913]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051343]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytokinesis [GO:0032465]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to calcium ion [GO:0051592]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
P0DP25	reviewed	CALM3_HUMAN	Calmodulin-3	CALM3 CALML2 CAM3 CAMC CAMIII	Homo sapiens (Human)	149	FUNCTION: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:31454269). Calcium-binding is required for the activation of calmodulin (PubMed:35568036, PubMed:16760425, PubMed:31454269). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:31454269, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631}.	MISCELLANEOUS: This protein has four functional calcium-binding sites. {ECO:0000269|PubMed:1474585}.	detection of calcium ion [GO:0005513]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of calcium ion export across plasma membrane [GO:1905913]; negative regulation of high voltage-gated calcium channel activity [GO:1901842]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051343]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytokinesis [GO:0032465]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to calcium ion [GO:0051592]; substantia nigra development [GO:0021762]	calcium channel complex [GO:0034704]; catalytic complex [GO:1902494]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; myelin sheath [GO:0043209]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076]	adenylate cyclase activator activity [GO:0010856]; adenylate cyclase binding [GO:0008179]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein kinase binding [GO:0019901]; protein phosphatase activator activity [GO:0072542]; protein serine/threonine kinase activator activity [GO:0043539]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325]	calcium channel complex [GO:0034704]; catalytic complex [GO:1902494]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; myelin sheath [GO:0043209]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076]; adenylate cyclase activator activity [GO:0010856]; adenylate cyclase binding [GO:0008179]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein kinase binding [GO:0019901]; protein phosphatase activator activity [GO:0072542]; protein serine/threonine kinase activator activity [GO:0043539]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325]; detection of calcium ion [GO:0005513]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of calcium ion export across plasma membrane [GO:1905913]; negative regulation of high voltage-gated calcium channel activity [GO:1901842]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051343]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytokinesis [GO:0032465]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to calcium ion [GO:0051592]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
P0DP57	reviewed	SLUR2_HUMAN	Secreted Ly-6/uPAR domain-containing protein 2 (Secreted LY6/PLAUR domain-containing protein 2) (Secreted Ly-6/uPAR-related protein 2) (SLURP-2)	SLURP2	Homo sapiens (Human)	97	FUNCTION: Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner. {ECO:0000269|PubMed:16575903, ECO:0000269|PubMed:27485575}.		acetylcholine receptor signaling pathway [GO:0095500]; regulation of neurotransmitter receptor activity [GO:0099601]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; synapse [GO:0045202]	acetylcholine receptor binding [GO:0033130]; acetylcholine receptor regulator activity [GO:0030548]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; synapse [GO:0045202]; acetylcholine receptor binding [GO:0033130]; acetylcholine receptor regulator activity [GO:0030548]; acetylcholine receptor signaling pathway [GO:0095500]; regulation of neurotransmitter receptor activity [GO:0099601]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16575903}.
P0DP58	reviewed	LYNX1_HUMAN	Ly-6/neurotoxin-like protein 1 (Endogenous prototoxin LYNX1) (Testicular tissue protein Li 112)	LYNX1	Homo sapiens (Human)	116	FUNCTION: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:21252236). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR (By similarity). In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs (PubMed:28100642). Prevents plasticity in the primary visual cortex late in life (By similarity). {ECO:0000250|UniProtKB:P0DP60, ECO:0000269|PubMed:21252236, ECO:0000269|PubMed:28100642}.	MISCELLANEOUS: Isoform 1 is considered to be an endogenous 'prototoxin', that shares a N-terminal three-finger structure with snake alpha-neurotoxins. {ECO:0000303|PubMed:21252236}.; MISCELLANEOUS: [Isoform 2]: Based on a naturally occurring readthrough transcript which produces a LYNX1-SLURP2 fusion protein. {ECO:0000305|PubMed:26033490}.	regulation of neurotransmitter receptor activity [GO:0099601]	dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	acetylcholine receptor binding [GO:0033130]; acetylcholine receptor regulator activity [GO:0030548]	dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; acetylcholine receptor binding [GO:0033130]; acetylcholine receptor regulator activity [GO:0030548]; regulation of neurotransmitter receptor activity [GO:0099601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:P0DP60}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P0DP60}. Note=Detected in Purkinje cells soma and proximal dendrites. {ECO:0000250|UniProtKB:P0DP60}.
P0DP91	reviewed	ERPG3_HUMAN	Chimeric ERCC6-PGBD3 protein (Chimeric CSB-PGBD3 protein)	ERCC6	Homo sapiens (Human)	1061	FUNCTION: Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6. In the presence of ERCC6, regulates the expression of genes involved in metabolism regulation, including IGFBP5 and IGFBP7. In vitro binds to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF. {ECO:0000269|PubMed:22483866}.	MISCELLANEOUS: [Isoform CSB-PGBD3]: Produced by an alternative splicing event that joins the first 5 exons of ERCC6 gene in frame to the entire PGBD3 coding region, which is located within ERCC6 intron 5. The resulting chimeric protein consists of the N-terminal 465 residues of ERCC6 tethered to the entire PGBD3 sequence. {ECO:0000269|PubMed:18369450}.	positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA repair [GO:0045739]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	sequence-specific DNA binding [GO:0043565]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; sequence-specific DNA binding [GO:0043565]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA repair [GO:0045739]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26218421}.
P0DPB3	reviewed	SCHI1_HUMAN	Schwannomin-interacting protein 1 (SCHIP-1)	SCHIP1	Homo sapiens (Human)	487			positive regulation of hippo signaling [GO:0035332]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; positive regulation of hippo signaling [GO:0035332]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10669747}.
P0DPB6	reviewed	RPAC2_HUMAN	DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) (RNA polymerase I 16 kDa subunit) (RPA16) (RPC16) (hRPA19)	POLR1D	Homo sapiens (Human)	133	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.		transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase III [GO:0006383]	RNA polymerase I complex [GO:0005736]; RNA polymerase III complex [GO:0005666]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]	RNA polymerase I complex [GO:0005736]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P0DPD6	reviewed	ECE2_HUMAN	Endothelin-converting enzyme 2 (ECE-2) (EC 3.4.24.71)	ECE2 KIAA0604 UNQ403/PRO740	Homo sapiens (Human)	811	FUNCTION: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity). {ECO:0000250|UniProtKB:B2RQR8, ECO:0000269|PubMed:12560336}.		cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; methylation [GO:0032259]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]	cytoplasmic vesicle membrane [GO:0030659]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; methyltransferase activity [GO:0008168]	cytoplasmic vesicle membrane [GO:0030659]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; methyltransferase activity [GO:0008168]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; methylation [GO:0032259]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:F1N476}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:F1N476}.
P0DPD7	reviewed	EFMT4_HUMAN	EEF1A lysine methyltransferase 4 (EC 2.1.1.-)	EEF1AKMT4	Homo sapiens (Human)	255	FUNCTION: Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2). {ECO:0000269|PubMed:28520920}.		methylation [GO:0032259]		methyltransferase activity [GO:0008168]; protein-lysine N-methyltransferase activity [GO:0016279]	methyltransferase activity [GO:0008168]; protein-lysine N-methyltransferase activity [GO:0016279]; methylation [GO:0032259]	
P0DPD8	reviewed	EFCE2_HUMAN	EEF1AKMT4-ECE2 readthrough transcript protein (EC 3.4.24.71) [Includes: Methyltransferase-like region (EC 2.1.1.-); Endothelin-converting enzyme 2 region (EC 3.4.24.71)]	EEF1AKMT4-ECE2	Homo sapiens (Human)	883	FUNCTION: Converts big endothelin-1 to endothelin-1. May also have methyltransferase activity (By similarity). May play a role in amyloid-beta processing (By similarity). {ECO:0000250|UniProtKB:P0DPD9, ECO:0000250|UniProtKB:P0DPE2}.	MISCELLANEOUS: [Isoform EEF1AKMT4-ECE2-1]: Based on a naturally occurring readthrough transcript which produces an EEF1AKMT4-ECE2 fusion protein. {ECO:0000305}.	brain development [GO:0007420]; cardioblast differentiation [GO:0010002]; heart development [GO:0007507]; methylation [GO:0032259]; protein processing [GO:0016485]	Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; brain development [GO:0007420]; cardioblast differentiation [GO:0010002]; heart development [GO:0007507]; methylation [GO:0032259]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:P0DPE2}; Single-pass membrane protein {ECO:0000250|UniProtKB:P0DPE2}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P0DPE2}.
P0DPH7	reviewed	TBA3C_HUMAN	Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain]	TUBA3C TUBA2	Homo sapiens (Human)	450	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		male germ-line stem cell population maintenance [GO:0036098]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; male germ-line stem cell population maintenance [GO:0036098]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P0DPH8	reviewed	TBA3D_HUMAN	Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain]	TUBA3D	Homo sapiens (Human)	450	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P0DPK2	reviewed	H3Y1_HUMAN	Histone H3.Y (Histone H3.Y1)	H3Y1	Homo sapiens (Human)	136	FUNCTION: Primate-specific variant histone H3, which constitutes a core component of nucleosomes (PubMed:20819935, PubMed:27016736). Histone H3.Y-containing nucleosomes accumulate around transcription start sites and have flexible DNA ends, suggesting that they form relaxed chromatin that allows transcription factor access (PubMed:27016736). Histone H1 binds less efficiently to histone H3.Y-containing nucleosomes (PubMed:27016736). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (Probable). {ECO:0000269|PubMed:20819935, ECO:0000269|PubMed:27016736, ECO:0000305}.			nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	nucleosomal DNA binding [GO:0031492]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; nucleosomal DNA binding [GO:0031492]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20819935}. Chromosome {ECO:0000269|PubMed:27016736, ECO:0000269|PubMed:28334823, ECO:0000305|PubMed:20819935}. Note=Histone H3.Y-containing nucleosomes are depleted from repressive post-translational histone modifications (PubMed:28334823). Histone H3.Y-containing nucleosomes accumulate around transcription start sites (PubMed:27016736). {ECO:0000269|PubMed:27016736, ECO:0000269|PubMed:28334823}.
P0DPK3	reviewed	NT2NB_HUMAN	Notch homolog 2 N-terminal-like protein B	NOTCH2NLB	Homo sapiens (Human)	275	FUNCTION: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954, PubMed:29856955). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (PubMed:29856955). {ECO:0000269|PubMed:29561261, ECO:0000269|PubMed:29856954, ECO:0000269|PubMed:29856955}.	MISCELLANEOUS: NOTCH2NLA, NOTCH2NLB and NOTCH2NLC paralogs arose between 4 and 3 million years ago, after the separation of hominids from the chimpanzee and during the early stages of the expansion of the human cortex. {ECO:0000269|PubMed:29856954}.	cerebral cortex development [GO:0021987]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]	extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; Notch binding [GO:0005112]	extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; cerebral cortex development [GO:0021987]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29856954, ECO:0000269|PubMed:29856955}.
P0DPK4	reviewed	NT2NC_HUMAN	Notch homolog 2 N-terminal-like protein C	NOTCH2NLC	Homo sapiens (Human)	293	FUNCTION: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity). {ECO:0000250|UniProtKB:P0DPK3, ECO:0000269|PubMed:29561261, ECO:0000269|PubMed:29856954, ECO:0000269|PubMed:29856955}.	MISCELLANEOUS: NOTCH2NLA, NOTCH2NLB and NOTCH2NLC paralogs arose between 4 and 3 million years ago, after the separation of hominids from the chimpanzee and during the early stages of the expansion of the human cortex. {ECO:0000269|PubMed:29856954}.	cerebral cortex development [GO:0021987]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]	extracellular region [GO:0005576]	calcium ion binding [GO:0005509]	extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; cerebral cortex development [GO:0021987]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29856954, ECO:0000269|PubMed:33693509}.
P0DPK5	reviewed	H3Y2_HUMAN	Histone H3.X (Histone H3.Y2)	H3Y2	Homo sapiens (Human)	147	FUNCTION: Primate-specific variant histone H3, which constitutes a core component of nucleosomes (PubMed:20819935). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (Probable). {ECO:0000269|PubMed:20819935, ECO:0000305}.			nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20819935}. Chromosome {ECO:0000305|PubMed:20819935}.
P0DTE4	reviewed	UD2A1_HUMAN	UDP-glucuronosyltransferase 2A1 (UDPGT 2A1) (UGT2A1) (EC 2.4.1.17)	UGT2A1	Homo sapiens (Human)	527	FUNCTION: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10359671, PubMed:19858781, PubMed:18719240, PubMed:19022937, PubMed:23756265, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:10359671, PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone and epitestosterone) and estrogens (estradiol and epiestriol) (PubMed:18719240, PubMed:19858781, PubMed:19022937, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction (PubMed:10359671). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781). {ECO:0000269|PubMed:10359671, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19022937, ECO:0000269|PubMed:19858781, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:23756265}.	MISCELLANEOUS: UGT2A1 isoform is part of the UGT2A complex locus which displays alternative use of promoters and exons. The locus is defined by 2 alternative promoters giving rise to 2 fonctionally active polypeptides UGT2A1 and UGT2A2. Alternative splicing of exons results in additional isoforms for each protein class. {ECO:0000303|PubMed:19858781}.	bile acid metabolic process [GO:0008206]; cellular glucuronidation [GO:0052695]; response to stimulus [GO:0050896]; sensory perception of chemical stimulus [GO:0007606]; sensory perception of smell [GO:0007608]	endoplasmic reticulum membrane [GO:0005789]	glucuronosyltransferase activity [GO:0015020]	endoplasmic reticulum membrane [GO:0005789]; glucuronosyltransferase activity [GO:0015020]; bile acid metabolic process [GO:0008206]; cellular glucuronidation [GO:0052695]; response to stimulus [GO:0050896]; sensory perception of chemical stimulus [GO:0007606]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:10359671}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:19858781}; Single-pass membrane protein {ECO:0000255}.
P0DTE5	reviewed	UD2A2_HUMAN	UDP-glucuronosyltransferase 2A2 (UDPGT 2A2) (EC 2.4.1.17)	UGT2A2	Homo sapiens (Human)	536	FUNCTION: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:19858781, PubMed:18719240, PubMed:23756265, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormone estradiol (PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781). {ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19858781, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:23756265}.	MISCELLANEOUS: UGT2A2 isoform is part of the UGT2A complex locus which displays alternative use of promoters and exons. The locus is defined by 2 alternative promoters resulting in 2 fonctionally active polypeptides UGT2A1 and UGT2A2. Alternative splicing of exons results in additional isoforms for each protein class. {ECO:0000303|PubMed:19858781}.	bile acid metabolic process [GO:0008206]; cellular glucuronidation [GO:0052695]	endoplasmic reticulum membrane [GO:0005789]	glucuronosyltransferase activity [GO:0015020]	endoplasmic reticulum membrane [GO:0005789]; glucuronosyltransferase activity [GO:0015020]; bile acid metabolic process [GO:0008206]; cellular glucuronidation [GO:0052695]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:19858781}; Multi-pass membrane protein {ECO:0000255}.
P0DTE7	reviewed	AMY1B_HUMAN	Alpha-amylase 1B (EC 3.2.1.1)	AMY1B AMY1	Homo sapiens (Human)	511	FUNCTION: Calcium-binding enzyme that initiates starch digestion in the oral cavity (PubMed:12527308). Catalyzes the hydrolysis of internal (1->4)-alpha-D-glucosidic bonds, yielding a mixture of maltose, isomaltose, small amounts of glucose as well as small linear and branched oligosaccharides called dextrins (PubMed:12527308). {ECO:0000269|PubMed:12527308}.		carbohydrate metabolic process [GO:0005975]; oligosaccharide metabolic process [GO:0009311]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	alpha-amylase activity [GO:0004556]; calcium ion binding [GO:0005509]; chloride ion binding [GO:0031404]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; alpha-amylase activity [GO:0004556]; calcium ion binding [GO:0005509]; chloride ion binding [GO:0031404]; carbohydrate metabolic process [GO:0005975]; oligosaccharide metabolic process [GO:0009311]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P0DTE8	reviewed	AMY1C_HUMAN	Alpha-amylase 1C (EC 3.2.1.1)	AMY1C AMY1	Homo sapiens (Human)	511	FUNCTION: Calcium-binding enzyme that initiates starch digestion in the oral cavity (PubMed:12527308). Catalyzes the hydrolysis of internal (1->4)-alpha-D-glucosidic bonds, yielding a mixture of maltose, isomaltose, small amounts of glucose as well as small linear and branched oligosaccharides called dextrins (PubMed:12527308). {ECO:0000269|PubMed:12527308}.		carbohydrate metabolic process [GO:0005975]; oligosaccharide metabolic process [GO:0009311]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	alpha-amylase activity [GO:0004556]; calcium ion binding [GO:0005509]; chloride ion binding [GO:0031404]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; alpha-amylase activity [GO:0004556]; calcium ion binding [GO:0005509]; chloride ion binding [GO:0031404]; carbohydrate metabolic process [GO:0005975]; oligosaccharide metabolic process [GO:0009311]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P0DTU3	reviewed	TRAR2_HUMAN	T cell receptor alpha chain MC.7.G5 (MC.7.G5 TRA) (TR alpha chain TRAV38-2DV8*01J31*01C*01)	TRA	Homo sapiens (Human)	275	FUNCTION: The alpha chain of TRAV38-2DV8*01J31*01C*01/TRBV25-1*01J2S3*01C2*01 alpha-beta T cell receptor (TR) clonotype that displays pan-cancer cell recognition via the invariant MR1 molecule. On CD8-positive T cell clone MC.7.G5, likely recognizes tumor-specific or -associated metabolite(s) essential for cancer cell survival, triggering killing of many cancer cell types including lung, melanoma, leukemia, colon, breast, prostate, bone and ovarian cancer cells. Mediates cancer cell cytotoxicity in an HLA-independent manner. Has no reactivity to healthy cells, even stressed or infected by bacteria (PubMed:31959982). Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity). {ECO:0000250|UniProtKB:P01848, ECO:0000269|PubMed:31959982}.		detection of tumor cell [GO:0002355]; response to bacterium [GO:0009617]; T cell mediated cytotoxicity directed against tumor cell target [GO:0002419]	alpha-beta T cell receptor complex [GO:0042105]	signaling receptor activity [GO:0038023]	alpha-beta T cell receptor complex [GO:0042105]; signaling receptor activity [GO:0038023]; detection of tumor cell [GO:0002355]; response to bacterium [GO:0009617]; T cell mediated cytotoxicity directed against tumor cell target [GO:0002419]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31959982}.
P0DTU4	reviewed	TRBR2_HUMAN	T cell receptor beta chain MC.7.G5 (TR beta chain TRBV25-1*01J2S3*01C2*01) (MC.7.G5 TRB)	TRB	Homo sapiens (Human)	315	FUNCTION: The beta chain of TRAV38-2DV8*01J31*01C*01/TRBV25-1*01J2S3*01C2*01 alpha-beta T cell receptor (TR) clonotype that displays pan-cancer cell recognition via the invariant MR1 molecule. On CD8-positive T cell clone MC.7.G5, likely recognizes tumor-specific or -associated metabolite(s) essential for cancer cell survival, triggering killing of many cancer cell types including lung, melanoma, leukemia, colon, breast, prostate, bone and ovarian cancer cells. Mediates cancer cell cytotoxicity in an HLA-independent manner. Has no reactivity to healthy cells even stressed or infected by bacteria (PubMed:31959982). Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity). {ECO:0000250|UniProtKB:P01848, ECO:0000269|PubMed:31959982}.		cell surface receptor signaling pathway [GO:0007166]; detection of tumor cell [GO:0002355]; T cell mediated cytotoxicity directed against tumor cell target [GO:0002419]	alpha-beta T cell receptor complex [GO:0042105]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	alpha-beta T cell receptor complex [GO:0042105]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; cell surface receptor signaling pathway [GO:0007166]; detection of tumor cell [GO:0002355]; T cell mediated cytotoxicity directed against tumor cell target [GO:0002419]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31959982}.
P0DUB6	reviewed	AMY1A_HUMAN	Alpha-amylase 1A (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase 1) (Salivary alpha-amylase)	AMY1A AMY1	Homo sapiens (Human)	511	FUNCTION: Calcium-binding enzyme that initiates starch digestion in the oral cavity (PubMed:12527308). Catalyzes the hydrolysis of internal (1->4)-alpha-D-glucosidic bonds, yielding a mixture of maltose, isomaltose, small amounts of glucose as well as small linear and branched oligosaccharides called dextrins (PubMed:12527308). {ECO:0000269|PubMed:12527308}.		carbohydrate metabolic process [GO:0005975]; oligosaccharide metabolic process [GO:0009311]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	alpha-amylase activity [GO:0004556]; calcium ion binding [GO:0005509]; chloride ion binding [GO:0031404]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; alpha-amylase activity [GO:0004556]; calcium ion binding [GO:0005509]; chloride ion binding [GO:0031404]; carbohydrate metabolic process [GO:0005975]; oligosaccharide metabolic process [GO:0009311]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P10070	reviewed	GLI2_HUMAN	Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein)	GLI2 THP	Homo sapiens (Human)	1586	FUNCTION: Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}.		axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cellular response to virus [GO:0098586]; cerebellar cortex morphogenesis [GO:0021696]; developmental growth [GO:0048589]; embryonic digestive tract development [GO:0048566]; epidermal cell differentiation [GO:0009913]; floor plate formation [GO:0021508]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; hindbrain development [GO:0030902]; hindgut morphogenesis [GO:0007442]; kidney development [GO:0001822]; lung development [GO:0030324]; mammary gland development [GO:0030879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast development [GO:0002076]; osteoblast differentiation [GO:0001649]; pattern specification process [GO:0007389]; pituitary gland development [GO:0021983]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; spinal cord dorsal/ventral patterning [GO:0021513]; spinal cord ventral commissure morphogenesis [GO:0021965]; tube development [GO:0035295]; ventral midline development [GO:0007418]; ventral spinal cord development [GO:0021517]	ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cellular response to virus [GO:0098586]; cerebellar cortex morphogenesis [GO:0021696]; developmental growth [GO:0048589]; embryonic digestive tract development [GO:0048566]; epidermal cell differentiation [GO:0009913]; floor plate formation [GO:0021508]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; hindbrain development [GO:0030902]; hindgut morphogenesis [GO:0007442]; kidney development [GO:0001822]; lung development [GO:0030324]; mammary gland development [GO:0030879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast development [GO:0002076]; osteoblast differentiation [GO:0001649]; pattern specification process [GO:0007389]; pituitary gland development [GO:0021983]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; spinal cord dorsal/ventral patterning [GO:0021513]; spinal cord ventral commissure morphogenesis [GO:0021965]; tube development [GO:0035295]; ventral midline development [GO:0007418]; ventral spinal cord development [GO:0021517]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26565916}. Cytoplasm {ECO:0000250|UniProtKB:Q0VGT2}. Cell projection, cilium {ECO:0000250|UniProtKB:Q0VGT2}. Note=STK36 promotes translocation to the nucleus. In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus. {ECO:0000250|UniProtKB:Q0VGT2}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:9557682}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:9557682}.
P10071	reviewed	GLI3_HUMAN	Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)]	GLI3	Homo sapiens (Human)	1580	FUNCTION: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}.		alpha-beta T cell differentiation [GO:0046632]; anterior semicircular canal development [GO:0060873]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; axon guidance [GO:0007411]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye morphogenesis [GO:0048593]; cell differentiation involved in kidney development [GO:0061005]; chondrocyte differentiation [GO:0002062]; developmental growth [GO:0048589]; embryonic digestive tract development [GO:0048566]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic neurocranium morphogenesis [GO:0048702]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain radial glial cell differentiation [GO:0021861]; frontal suture morphogenesis [GO:0060364]; heart development [GO:0007507]; hindgut morphogenesis [GO:0007442]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; lambdoid suture morphogenesis [GO:0060366]; larynx morphogenesis [GO:0120223]; lateral ganglionic eminence cell proliferation [GO:0022018]; lateral semicircular canal development [GO:0060875]; layer formation in cerebral cortex [GO:0021819]; limb morphogenesis [GO:0035108]; lung development [GO:0030324]; mammary gland specification [GO:0060594]; melanocyte differentiation [GO:0030318]; metanephros development [GO:0001656]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative thymic T cell selection [GO:0045060]; neuroblast proliferation [GO:0007405]; nose morphogenesis [GO:0043585]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; optic nerve morphogenesis [GO:0021631]; osteoblast differentiation [GO:0001649]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein processing [GO:0016485]; proximal/distal pattern formation [GO:0009954]; regulation of bone development [GO:1903010]; regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901620]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; sagittal suture morphogenesis [GO:0060367]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; thymocyte apoptotic process [GO:0070242]; tongue development [GO:0043586]; vocalization behavior [GO:0071625]	axoneme [GO:0005930]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; mediator complex binding [GO:0036033]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	axoneme [GO:0005930]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; mediator complex binding [GO:0036033]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; alpha-beta T cell differentiation [GO:0046632]; anterior semicircular canal development [GO:0060873]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; axon guidance [GO:0007411]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye morphogenesis [GO:0048593]; cell differentiation involved in kidney development [GO:0061005]; chondrocyte differentiation [GO:0002062]; developmental growth [GO:0048589]; embryonic digestive tract development [GO:0048566]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic neurocranium morphogenesis [GO:0048702]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain radial glial cell differentiation [GO:0021861]; frontal suture morphogenesis [GO:0060364]; heart development [GO:0007507]; hindgut morphogenesis [GO:0007442]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; lambdoid suture morphogenesis [GO:0060366]; larynx morphogenesis [GO:0120223]; lateral ganglionic eminence cell proliferation [GO:0022018]; lateral semicircular canal development [GO:0060875]; layer formation in cerebral cortex [GO:0021819]; limb morphogenesis [GO:0035108]; lung development [GO:0030324]; mammary gland specification [GO:0060594]; melanocyte differentiation [GO:0030318]; metanephros development [GO:0001656]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative thymic T cell selection [GO:0045060]; neuroblast proliferation [GO:0007405]; nose morphogenesis [GO:0043585]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; optic nerve morphogenesis [GO:0021631]; osteoblast differentiation [GO:0001649]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein processing [GO:0016485]; proximal/distal pattern formation [GO:0009954]; regulation of bone development [GO:1903010]; regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901620]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; sagittal suture morphogenesis [GO:0060367]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; thymocyte apoptotic process [GO:0070242]; tongue development [GO:0043586]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cell projection, cilium. Note=GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requires the presence of KIF7 and SMO. Translocation to the nucleus is promoted by interaction with ZIC1.
P10073	reviewed	ZSC22_HUMAN	Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50)	ZSCAN22 HKR2 ZNF50	Homo sapiens (Human)	491	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
P10074	reviewed	TZAP_HUMAN	Telomere zinc finger-associated protein (TZAP) (Krueppel-related zinc finger protein 3) (hKR3) (Zinc finger and BTB domain-containing protein 48) (Zinc finger protein 855)	ZBTB48 HKR3 TZAP ZNF855	Homo sapiens (Human)	688	FUNCTION: Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). {ECO:0000269|PubMed:24382891, ECO:0000269|PubMed:28082411, ECO:0000269|PubMed:28500257, ECO:0000269|PubMed:7969177}.		positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; telomere maintenance via telomere lengthening [GO:0010833]	chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; double-stranded telomeric DNA binding [GO:0003691]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; double-stranded telomeric DNA binding [GO:0003691]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; telomere maintenance via telomere lengthening [GO:0010833]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere {ECO:0000269|PubMed:28082411, ECO:0000269|PubMed:28500257}. Note=Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2 (PubMed:28082411). According to another report, binds telomeres regardless of their length (PubMed:28500257). {ECO:0000269|PubMed:28082411, ECO:0000269|PubMed:28500257}.
P10082	reviewed	PYY_HUMAN	Peptide YY (PYY) (PYY-I) (Peptide tyrosine tyrosine) [Cleaved into: Peptide YY(3-36) (PYY-II)]	PYY	Homo sapiens (Human)	97	FUNCTION: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.		feeding behavior [GO:0007631]; intestinal epithelial cell differentiation [GO:0060575]; neuropeptide signaling pathway [GO:0007218]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; neuropeptide Y receptor binding [GO:0031841]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; neuropeptide Y receptor binding [GO:0031841]; feeding behavior [GO:0007631]; intestinal epithelial cell differentiation [GO:0060575]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Secreted.
P10092	reviewed	CALCB_HUMAN	Calcitonin gene-related peptide 2 (Beta-type CGRP) (Beta-CGRP) (Calcitonin gene-related peptide II) (CGRP-II)	CALCB CALC2	Homo sapiens (Human)	127	FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; intracellular calcium ion homeostasis [GO:0006874]; regulation of cytosolic calcium ion concentration [GO:0051480]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcitonin receptor binding [GO:0031716]; neuropeptide hormone activity [GO:0005184]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcitonin receptor binding [GO:0031716]; neuropeptide hormone activity [GO:0005184]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; intracellular calcium ion homeostasis [GO:0006874]; regulation of cytosolic calcium ion concentration [GO:0051480]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P10109	reviewed	ADX_HUMAN	Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin)	FDX1 ADX	Homo sapiens (Human)	184	FUNCTION: Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). {ECO:0000250|UniProtKB:P00257, ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}.		cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cholesterol metabolic process [GO:0008203]; electron transport chain [GO:0022900]; hormone biosynthetic process [GO:0042446]; P450-containing electron transport chain [GO:0140647]; steroid biosynthetic process [GO:0006694]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]; cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cholesterol metabolic process [GO:0008203]; electron transport chain [GO:0022900]; hormone biosynthetic process [GO:0042446]; P450-containing electron transport chain [GO:0140647]; steroid biosynthetic process [GO:0006694]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:20547883}.
P10114	reviewed	RAP2A_HUMAN	Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30)	RAP2A	Homo sapiens (Human)	183	FUNCTION: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. {ECO:0000269|PubMed:14966141, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:16246175, ECO:0000269|PubMed:16540189, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:20159449}.		actin cytoskeleton organization [GO:0030036]; cellular response to xenobiotic stimulus [GO:0071466]; establishment of protein localization [GO:0045184]; microvillus assembly [GO:0030033]; negative regulation of cell migration [GO:0030336]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein phosphorylation [GO:0001934]; protein localization [GO:0008104]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; regulation of dendrite morphogenesis [GO:0048814]; regulation of JNK cascade [GO:0046328]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of synapse assembly [GO:0051963]	cytosol [GO:0005829]; midbody [GO:0030496]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; midbody [GO:0030496]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; actin cytoskeleton organization [GO:0030036]; cellular response to xenobiotic stimulus [GO:0071466]; establishment of protein localization [GO:0045184]; microvillus assembly [GO:0030033]; negative regulation of cell migration [GO:0030336]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein phosphorylation [GO:0001934]; protein localization [GO:0008104]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; regulation of dendrite morphogenesis [GO:0048814]; regulation of JNK cascade [GO:0046328]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of synapse assembly [GO:0051963]	SUBCELLULAR LOCATION: Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995). Colocalizes with RASGEF1B to midbody at telophase (PubMed:23894443). {ECO:0000269|PubMed:23894443, ECO:0000269|PubMed:7962206, ECO:0000269|PubMed:8391995}.
P10124	reviewed	SRGN_HUMAN	Serglycin (Hematopoietic proteoglycan core protein) (Platelet proteoglycan core protein) (P.PG) (Secretory granule proteoglycan core protein)	SRGN PRG PRG1	Homo sapiens (Human)	158	FUNCTION: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization. {ECO:0000269|PubMed:11911826, ECO:0000269|PubMed:16420477, ECO:0000269|PubMed:16870619}.		apoptotic process [GO:0006915]; biomineral tissue development [GO:0031214]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; maintenance of granzyme B location in T cell secretory granule [GO:0033382]; maintenance of protease location in mast cell secretory granule [GO:0033373]; mast cell secretory granule organization [GO:0033364]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cytokine production [GO:0001818]; protein processing [GO:0016485]; regulation of postsynapse organization [GO:0099175]; secretory granule organization [GO:0033363]; T cell secretory granule organization [GO:0033371]	cytolytic granule [GO:0044194]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; mast cell granule [GO:0042629]; platelet alpha granule lumen [GO:0031093]; postsynaptic specialization, intracellular component [GO:0099091]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]		cytolytic granule [GO:0044194]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; mast cell granule [GO:0042629]; platelet alpha granule lumen [GO:0031093]; postsynaptic specialization, intracellular component [GO:0099091]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; apoptotic process [GO:0006915]; biomineral tissue development [GO:0031214]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; maintenance of granzyme B location in T cell secretory granule [GO:0033382]; maintenance of protease location in mast cell secretory granule [GO:0033373]; mast cell secretory granule organization [GO:0033364]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cytokine production [GO:0001818]; protein processing [GO:0016485]; regulation of postsynapse organization [GO:0099175]; secretory granule organization [GO:0033363]; T cell secretory granule organization [GO:0033371]	SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000269|PubMed:11154222}. Cytolytic granule {ECO:0000269|PubMed:11154222}. Secreted, extracellular space {ECO:0000269|PubMed:11154222, ECO:0000269|PubMed:16870619}. Golgi apparatus {ECO:0000269|PubMed:11154222, ECO:0000269|PubMed:15136585}. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity). Secreted constitutively by endothelial cells and macrophages (PubMed:11154222). Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585). {ECO:0000250|UniProtKB:P13609, ECO:0000269|PubMed:11154222, ECO:0000269|PubMed:15136585}.
P10144	reviewed	GRAB_HUMAN	Granzyme B (EC 3.4.21.79) (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (T-cell serine protease 1-3E)	GZMB CGL1 CSPB CTLA1 GRB	Homo sapiens (Human)	247	FUNCTION: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3262682, PubMed:3263427, PubMed:1985927). It cleaves after Asp (PubMed:8258716, PubMed:1985927). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed:32188940, PubMed:31953257). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis (PubMed:9852092). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (By similarity). {ECO:0000250|UniProtKB:P04187, ECO:0000269|PubMed:1985927, ECO:0000269|PubMed:31953257, ECO:0000269|PubMed:32188940, ECO:0000269|PubMed:3262682, ECO:0000269|PubMed:3263427, ECO:0000269|PubMed:8258716, ECO:0000269|PubMed:9852092}.		apoptotic process [GO:0006915]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; killing of cells of another organism [GO:0031640]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of translation [GO:0017148]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; protein maturation [GO:0051604]; proteolysis involved in protein catabolic process [GO:0051603]; pyroptosis [GO:0070269]	cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; apoptotic process [GO:0006915]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; killing of cells of another organism [GO:0031640]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of translation [GO:0017148]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; protein maturation [GO:0051604]; proteolysis involved in protein catabolic process [GO:0051603]; pyroptosis [GO:0070269]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:8258716}. Cytolytic granule {ECO:0000269|PubMed:1985927, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:8258716}. Note=Delivered into the target cell by perforin (PubMed:20038786). {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:8258716}.
P10145	reviewed	IL8_HUMAN	Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)]	CXCL8 IL8	Homo sapiens (Human)	99	FUNCTION: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:7636208, PubMed:18692776). Also plays an important role in neutrophil activation (PubMed:9623510, PubMed:2145175). Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells (PubMed:1840701, PubMed:1891716). G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways (PubMed:8662698, PubMed:11971003). {ECO:0000269|PubMed:11971003, ECO:0000269|PubMed:11978786, ECO:0000269|PubMed:1840701, ECO:0000269|PubMed:18692776, ECO:0000269|PubMed:1891716, ECO:0000269|PubMed:2145175, ECO:0000269|PubMed:2212672, ECO:0000269|PubMed:7636208, ECO:0000269|PubMed:8662698, ECO:0000269|PubMed:9623510}.		angiogenesis [GO:0001525]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; calcium-mediated signaling [GO:0019722]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; embryonic digestive tract development [GO:0048566]; G protein-coupled receptor signaling pathway [GO:0007186]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of gene expression [GO:0010629]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cellular biosynthetic process [GO:0031328]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil chemotaxis [GO:0090023]; receptor internalization [GO:0031623]; regulation of cell adhesion [GO:0030155]; regulation of entry of bacterium into host cell [GO:2000535]; regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045091]; response to endoplasmic reticulum stress [GO:0034976]; response to molecule of bacterial origin [GO:0002237]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; heparin binding [GO:0008201]; interleukin-8 receptor binding [GO:0005153]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; heparin binding [GO:0008201]; interleukin-8 receptor binding [GO:0005153]; angiogenesis [GO:0001525]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; calcium-mediated signaling [GO:0019722]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; embryonic digestive tract development [GO:0048566]; G protein-coupled receptor signaling pathway [GO:0007186]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of gene expression [GO:0010629]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cellular biosynthetic process [GO:0031328]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil chemotaxis [GO:0090023]; receptor internalization [GO:0031623]; regulation of cell adhesion [GO:0030155]; regulation of entry of bacterium into host cell [GO:2000535]; regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045091]; response to endoplasmic reticulum stress [GO:0034976]; response to molecule of bacterial origin [GO:0002237]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P10147	reviewed	CCL3_HUMAN	C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]	CCL3 G0S19-1 MIP1A SCYA3	Homo sapiens (Human)	92	FUNCTION: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). {ECO:0000269|PubMed:8525373}.		astrocyte cell migration [GO:0043615]; calcium ion transport [GO:0006816]; calcium-mediated signaling [GO:0019722]; cell activation [GO:0001775]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; eosinophil degranulation [GO:0043308]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; MAPK cascade [GO:0000165]; monocyte chemotaxis [GO:0002548]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of bone mineralization [GO:0030502]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoclast differentiation [GO:0045671]; neutrophil chemotaxis [GO:0030593]; osteoblast differentiation [GO:0001649]; positive regulation of calcium ion import [GO:0090280]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of natural killer cell chemotaxis [GO:2000503]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of behavior [GO:0050795]; regulation of cell shape [GO:0008360]; regulation of sensory perception of pain [GO:0051930]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to cholesterol [GO:0070723]; response to toxic substance [GO:0009636]; signaling [GO:0023052]; T cell chemotaxis [GO:0010818]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR1 chemokine receptor binding [GO:0031726]; CCR5 chemokine receptor binding [GO:0031730]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; phospholipase activator activity [GO:0016004]; protein kinase activity [GO:0004672]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR1 chemokine receptor binding [GO:0031726]; CCR5 chemokine receptor binding [GO:0031730]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; phospholipase activator activity [GO:0016004]; protein kinase activity [GO:0004672]; astrocyte cell migration [GO:0043615]; calcium ion transport [GO:0006816]; calcium-mediated signaling [GO:0019722]; cell activation [GO:0001775]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; eosinophil degranulation [GO:0043308]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; MAPK cascade [GO:0000165]; monocyte chemotaxis [GO:0002548]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of bone mineralization [GO:0030502]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoclast differentiation [GO:0045671]; neutrophil chemotaxis [GO:0030593]; osteoblast differentiation [GO:0001649]; positive regulation of calcium ion import [GO:0090280]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of natural killer cell chemotaxis [GO:2000503]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of behavior [GO:0050795]; regulation of cell shape [GO:0008360]; regulation of sensory perception of pain [GO:0051930]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to cholesterol [GO:0070723]; response to toxic substance [GO:0009636]; signaling [GO:0023052]; T cell chemotaxis [GO:0010818]	SUBCELLULAR LOCATION: Secreted.
P10153	reviewed	RNAS2_HUMAN	Non-secretory ribonuclease (EC 4.6.1.18) (Eosinophil-derived neurotoxin) (RNase UpI-2) (Ribonuclease 2) (RNase 2) (Ribonuclease US)	RNASE2 EDN RNS2	Homo sapiens (Human)	161	FUNCTION: This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:3458170}.		chemotaxis [GO:0006935]; defense response to virus [GO:0051607]; innate immune response in mucosa [GO:0002227]; RNA catabolic process [GO:0006401]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540]; chemotaxis [GO:0006935]; defense response to virus [GO:0051607]; innate immune response in mucosa [GO:0002227]; RNA catabolic process [GO:0006401]	SUBCELLULAR LOCATION: Lysosome {ECO:0000305}. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule.
P10155	reviewed	RO60_HUMAN	RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2)	RO60 SSA2 TROVE2	Homo sapiens (Human)	538	FUNCTION: RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:18056422, PubMed:26382853). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion (PubMed:26382853). Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853). May play roles in cilia formation and/or maintenance (By similarity). {ECO:0000250|UniProtKB:O08848, ECO:0000269|PubMed:18056422, ECO:0000269|PubMed:26382853}.	MISCELLANEOUS: Antibodies against normal cellular SSA2 protein are found in sera from patients with systemic lupus erythematosus (SLE).	cellular response to interferon-alpha [GO:0035457]; cilium assembly [GO:0060271]; immune system development [GO:0002520]; regulation of gene expression [GO:0010468]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase III [GO:0006383]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620]; cellular response to interferon-alpha [GO:0035457]; cilium assembly [GO:0060271]; immune system development [GO:0002520]; regulation of gene expression [GO:0010468]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:17289661}.
P10163	reviewed	PRB4_HUMAN	Basic salivary proline-rich protein 4 (Salivary proline-rich protein Po) (Parotid o protein) (Salivary proline-rich protein II-1) [Cleaved into: Protein N1; Glycosylated protein A; Peptide P-D (Proline-rich peptide IB-5)]	PRB4	Homo sapiens (Human)	310				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted.
P10176	reviewed	COX8A_HUMAN	Cytochrome c oxidase subunit 8A, mitochondrial (Cytochrome c oxidase polypeptide VIII-liver/heart) (Cytochrome c oxidase subunit 8-2)	COX8A COX8 COX8L	Homo sapiens (Human)	69	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10175}.		cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]	cytochrome-c oxidase activity [GO:0004129]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]; cytochrome-c oxidase activity [GO:0004129]; cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
P10242	reviewed	MYB_HUMAN	Transcriptional activator Myb (Proto-oncogene c-Myb)	MYB	Homo sapiens (Human)	640	FUNCTION: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; erythrocyte differentiation [GO:0030218]; mitotic cell cycle [GO:0000278]; myeloid cell development [GO:0061515]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell proliferation [GO:1904899]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of testosterone secretion [GO:2000845]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; skeletal muscle cell proliferation [GO:0014856]; T-helper 2 cell differentiation [GO:0045064]	cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; erythrocyte differentiation [GO:0030218]; mitotic cell cycle [GO:0000278]; myeloid cell development [GO:0061515]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell proliferation [GO:1904899]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of testosterone secretion [GO:2000845]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; skeletal muscle cell proliferation [GO:0014856]; T-helper 2 cell differentiation [GO:0045064]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:19646965}.
P10243	reviewed	MYBA_HUMAN	Myb-related protein A (A-Myb) (Myb-like protein 1)	MYBL1 AMYB	Homo sapiens (Human)	752	FUNCTION: Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity). {ECO:0000250|UniProtKB:P51960, ECO:0000269|PubMed:7987850, ECO:0000269|PubMed:8058310}.		cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; mitotic cell cycle [GO:0000278]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of piRNA transcription [GO:0140543]; positive regulation of transcription by RNA polymerase II [GO:0045944]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; mitotic cell cycle [GO:0000278]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of piRNA transcription [GO:0140543]; positive regulation of transcription by RNA polymerase II [GO:0045944]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P51960}.
P10244	reviewed	MYBB_HUMAN	Myb-related protein B (B-Myb) (Myb-like protein 2)	MYBL2 BMYB	Homo sapiens (Human)	700	FUNCTION: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}.		cellular response to leukemia inhibitory factor [GO:1990830]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytosol [GO:0005829]; Myb complex [GO:0031523]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	cytosol [GO:0005829]; Myb complex [GO:0031523]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to leukemia inhibitory factor [GO:1990830]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus.
P10253	reviewed	LYAG_HUMAN	Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase]	GAA	Homo sapiens (Human)	952	FUNCTION: Essential for the degradation of glycogen in lysosomes (PubMed:1856189, PubMed:7717400, PubMed:14695532, PubMed:18429042). Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans (PubMed:29061980). {ECO:0000269|PubMed:14695532, ECO:0000269|PubMed:18429042, ECO:0000269|PubMed:1856189, ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:7717400}.		aorta development [GO:0035904]; cardiac muscle contraction [GO:0060048]; diaphragm contraction [GO:0002086]; glucose metabolic process [GO:0006006]; glycogen catabolic process [GO:0005980]; glycophagy [GO:0061723]; heart morphogenesis [GO:0003007]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; maltose metabolic process [GO:0000023]; muscle cell cellular homeostasis [GO:0046716]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; regulation of the force of heart contraction [GO:0002026]; sucrose metabolic process [GO:0005985]; tissue development [GO:0009888]; vacuolar sequestering [GO:0043181]	autolysosome lumen [GO:0120282]; azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	alpha-1,4-glucosidase activity [GO:0004558]; alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246]; maltose alpha-glucosidase activity [GO:0032450]	autolysosome lumen [GO:0120282]; azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; alpha-1,4-glucosidase activity [GO:0004558]; alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246]; maltose alpha-glucosidase activity [GO:0032450]; aorta development [GO:0035904]; cardiac muscle contraction [GO:0060048]; diaphragm contraction [GO:0002086]; glucose metabolic process [GO:0006006]; glycogen catabolic process [GO:0005980]; glycophagy [GO:0061723]; heart morphogenesis [GO:0003007]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; maltose metabolic process [GO:0000023]; muscle cell cellular homeostasis [GO:0046716]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; regulation of the force of heart contraction [GO:0002026]; sucrose metabolic process [GO:0005985]; tissue development [GO:0009888]; vacuolar sequestering [GO:0043181]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:17897319}. Lysosome membrane {ECO:0000269|PubMed:17897319}.
P10265	reviewed	VPK10_HUMAN	Endogenous retrovirus group K member 10 Pro protein (HERV-K10 Pro protein) (HERV-K107 Pro protein) (HERV-K_5q33.3 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)	ERVK-10	Homo sapiens (Human)	156	FUNCTION: Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein has retained most of the characteristics of retroviral proteases.		proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; proteolysis [GO:0006508]	
P10275	reviewed	ANDR_HUMAN	Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)	AR DHTR NR3C4	Homo sapiens (Human)	920	FUNCTION: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.	MISCELLANEOUS: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.; MISCELLANEOUS: Transcriptional activity is enhanced by binding to RANBP9.; MISCELLANEOUS: The level of tyrosine phosphorylation may serve as a diagnostic tool to predict patient outcome in response to hormone-ablation therapy. Inhibition of tyrosine phosphorylation may be an effective intervention target for hormone-refractory prostate cancer.; MISCELLANEOUS: [Isoform 3]: Minor isoform up-regulated in prostate cancer cells. {ECO:0000269|PubMed:19244107}.; MISCELLANEOUS: [Isoform 4]: Minor isoform identified in prostate cancer cells. {ECO:0000269|PubMed:19244107}.	activation of prostate induction by androgen receptor signaling pathway [GO:0060520]; androgen receptor signaling pathway [GO:0030521]; animal organ formation [GO:0048645]; cell-cell signaling [GO:0007267]; cellular response to estrogen stimulus [GO:0071391]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to testosterone stimulus [GO:0071394]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; epithelial cell morphogenesis [GO:0003382]; epithelial cell proliferation [GO:0050673]; in utero embryonic development [GO:0001701]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular estrogen receptor signaling pathway [GO:0030520]; intracellular receptor signaling pathway [GO:0030522]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599]; Leydig cell differentiation [GO:0033327]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; male somatic sex determination [GO:0019102]; mammary gland alveolus development [GO:0060749]; MAPK cascade [GO:0000165]; morphogenesis of an epithelial fold [GO:0060571]; multicellular organism growth [GO:0035264]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of integrin biosynthetic process [GO:0045720]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland growth [GO:0060736]; regulation of developmental growth [GO:0048638]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of systemic arterial blood pressure [GO:0003073]; seminiferous tubule development [GO:0072520]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	androgen binding [GO:0005497]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled receptor activity [GO:0004930]; molecular adaptor activity [GO:0060090]; nuclear receptor activity [GO:0004879]; POU domain binding [GO:0070974]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]; steroid binding [GO:0005496]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; androgen binding [GO:0005497]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled receptor activity [GO:0004930]; molecular adaptor activity [GO:0060090]; nuclear receptor activity [GO:0004879]; POU domain binding [GO:0070974]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]; steroid binding [GO:0005496]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]; activation of prostate induction by androgen receptor signaling pathway [GO:0060520]; androgen receptor signaling pathway [GO:0030521]; animal organ formation [GO:0048645]; cell-cell signaling [GO:0007267]; cellular response to estrogen stimulus [GO:0071391]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to testosterone stimulus [GO:0071394]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; epithelial cell morphogenesis [GO:0003382]; epithelial cell proliferation [GO:0050673]; in utero embryonic development [GO:0001701]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular estrogen receptor signaling pathway [GO:0030520]; intracellular receptor signaling pathway [GO:0030522]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599]; Leydig cell differentiation [GO:0033327]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; male somatic sex determination [GO:0019102]; mammary gland alveolus development [GO:0060749]; MAPK cascade [GO:0000165]; morphogenesis of an epithelial fold [GO:0060571]; multicellular organism growth [GO:0035264]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of integrin biosynthetic process [GO:0045720]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland growth [GO:0060736]; regulation of developmental growth [GO:0048638]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of systemic arterial blood pressure [GO:0003073]; seminiferous tubule development [GO:0072520]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:15634333, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:19244107, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:25091737}. Cytoplasm {ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:19244107}. Note=Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. {ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:25091737}.
P10276	reviewed	RARA_HUMAN	Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)	RARA NR1B1	Homo sapiens (Human)	462	FUNCTION: Receptor for retinoic acid (PubMed:19850744, PubMed:16417524, PubMed:20215566). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:28167758). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:28167758, PubMed:19398580). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:9267036, PubMed:19850744, PubMed:20215566). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19398580, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:9267036}.	MISCELLANEOUS: [Isoform Alpha-1-deltaBC]: Does not bind nor transactivate RARE on its own but may do so as a heterodimer with Alpha-1. {ECO:0000305}.	apoptotic cell clearance [GO:0043277]; cell differentiation [GO:0030154]; cellular response to estrogen stimulus [GO:0071391]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; chondroblast differentiation [GO:0060591]; embryonic camera-type eye development [GO:0031076]; face development [GO:0060324]; female pregnancy [GO:0007565]; germ cell development [GO:0007281]; glandular epithelial cell development [GO:0002068]; growth plate cartilage development [GO:0003417]; hippocampus development [GO:0021766]; hormone-mediated signaling pathway [GO:0009755]; limb development [GO:0060173]; liver development [GO:0001889]; mRNA transcription by RNA polymerase II [GO:0042789]; multicellular organism growth [GO:0035264]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; neural tube closure [GO:0001843]; positive regulation of binding [GO:0051099]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of myelination [GO:0031641]; regulation of synaptic plasticity [GO:0048167]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinoic acid receptor signaling pathway [GO:0048384]; Sertoli cell fate commitment [GO:0060010]; trachea cartilage development [GO:0060534]; ureteric bud development [GO:0001657]; ventricular cardiac muscle cell differentiation [GO:0055012]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	alpha-actinin binding [GO:0051393]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; mRNA 5'-UTR binding [GO:0048027]; mRNA regulatory element binding translation repressor activity [GO:0000900]; nuclear receptor activity [GO:0004879]; protein domain specific binding [GO:0019904]; protein kinase A binding [GO:0051018]; protein kinase B binding [GO:0043422]; retinoic acid binding [GO:0001972]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor binding [GO:0005102]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]; alpha-actinin binding [GO:0051393]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; mRNA 5'-UTR binding [GO:0048027]; mRNA regulatory element binding translation repressor activity [GO:0000900]; nuclear receptor activity [GO:0004879]; protein domain specific binding [GO:0019904]; protein kinase A binding [GO:0051018]; protein kinase B binding [GO:0043422]; retinoic acid binding [GO:0001972]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor binding [GO:0005102]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]; apoptotic cell clearance [GO:0043277]; cell differentiation [GO:0030154]; cellular response to estrogen stimulus [GO:0071391]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; chondroblast differentiation [GO:0060591]; embryonic camera-type eye development [GO:0031076]; face development [GO:0060324]; female pregnancy [GO:0007565]; germ cell development [GO:0007281]; glandular epithelial cell development [GO:0002068]; growth plate cartilage development [GO:0003417]; hippocampus development [GO:0021766]; hormone-mediated signaling pathway [GO:0009755]; limb development [GO:0060173]; liver development [GO:0001889]; mRNA transcription by RNA polymerase II [GO:0042789]; multicellular organism growth [GO:0035264]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; neural tube closure [GO:0001843]; positive regulation of binding [GO:0051099]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of myelination [GO:0031641]; regulation of synaptic plasticity [GO:0048167]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinoic acid receptor signaling pathway [GO:0048384]; Sertoli cell fate commitment [GO:0060010]; trachea cartilage development [GO:0060534]; ureteric bud development [GO:0001657]; ventricular cardiac muscle cell differentiation [GO:0055012]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:28167758}. Cytoplasm {ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:28167758}. Note=Nuclear localization depends on ligand binding, phosphorylation and sumoylation (PubMed:19850744). Translocation to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation (By similarity). Increased nuclear localization upon pulsatile shear stress (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:28167758}.
P10301	reviewed	RRAS_HUMAN	Ras-related protein R-Ras (EC 3.6.5.-) (p23)	RRAS	Homo sapiens (Human)	218	FUNCTION: Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). {ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:18270267}.		face morphogenesis [GO:0060325]; leukocyte differentiation [GO:0002521]; negative regulation of Schwann cell migration [GO:1900148]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of vasculogenesis [GO:2001214]; Ras protein signal transduction [GO:0007265]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; Schwann cell migration [GO:0036135]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-containing complex binding [GO:0044877]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-containing complex binding [GO:0044877]; face morphogenesis [GO:0060325]; leukocyte differentiation [GO:0002521]; negative regulation of Schwann cell migration [GO:1900148]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of vasculogenesis [GO:2001214]; Ras protein signal transduction [GO:0007265]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; Schwann cell migration [GO:0036135]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
P10321	reviewed	HLAC_HUMAN	HLA class I histocompatibility antigen, C alpha chain (HLA-C) (HLA-Cw) (Human leukocyte antigen C)	HLA-C HLAC	Homo sapiens (Human)	366	FUNCTION: Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity (PubMed:20972337, PubMed:24091323, PubMed:20439706, PubMed:11172028, PubMed:20104487, PubMed:28649982, PubMed:29312307). In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells (PubMed:16141329). In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary for placentation and overall fetal growth (PubMed:20972337, PubMed:24091323). During viral infection, may present viral peptides with low affinity for KIRs, impeding KIR-mediated inhibition through peptide antagonism and favoring lysis of infected cells (PubMed:20439706). Presents a restricted repertoire of viral peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-C-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected cells, particularly in chronic viral infection settings such as HIV-1 or CMV infection (PubMed:11172028, PubMed:20104487, PubMed:28649982). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (By similarity). Typically presents intracellular peptide antigens of 9 amino acids that arise from cytosolic proteolysis via proteasome. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9. Preferentially displays peptides having a restricted repertoire of hydrophobic or aromatic amino acids (Phe, Ile, Leu, Met, Val and Tyr) at the C-terminal anchor (PubMed:8265661, PubMed:25311805). {ECO:0000250|UniProtKB:P04439, ECO:0000269|PubMed:11172028, ECO:0000269|PubMed:16141329, ECO:0000269|PubMed:20104487, ECO:0000269|PubMed:20439706, ECO:0000269|PubMed:20972337, ECO:0000269|PubMed:24091323, ECO:0000269|PubMed:25311805, ECO:0000269|PubMed:28649982, ECO:0000269|PubMed:29312307, ECO:0000269|PubMed:8265661}.; FUNCTION: ALLELE C*01:02: The peptide-bound form interacts with KIR2DL2 and KIR2DL3 inhibitory receptors on NK cells. The low affinity peptides compete with the high affinity peptides impeding KIR-mediated inhibition and favoring lysis of infected cells (PubMed:20439706). Presents to CD8-positive T cells a CMV epitope derived from UL83/pp65 (RCPEMISVL), an immediate-early antigen necessary for initiating viral replication (PubMed:12947002). {ECO:0000269|PubMed:12947002, ECO:0000269|PubMed:20439706}.; FUNCTION: ALLELE C*04:01: Presents a conserved HIV-1 epitope derived from env (SFNCGGEFF) to memory CD8-positive T cells, eliciting very strong IFNG responses (PubMed:20104487). Presents CMV epitope derived from UL83/pp65 (QYDPVAALF) to CD8-positive T cells, triggering T cell cytotoxic response (PubMed:12947002). {ECO:0000269|PubMed:12947002, ECO:0000269|PubMed:20104487}.; FUNCTION: ALLELE C*05:01: Presents HIV-1 epitope derived from rev (SAEPVPLQL) to CD8-positive T cells, triggering T cell cytotoxic response. {ECO:0000269|PubMed:11172028}.; FUNCTION: ALLELE C*06:02: In trophoblasts, interacts with KIR2DS2 on uterine NK cells and triggers NK cell activation, including secretion of cytokines such as GMCSF that enhances trophoblast migration. {ECO:0000269|PubMed:24091323}.; FUNCTION: ALLELE C*07:02: Plays an important role in the control of chronic CMV infection. Presents immunodominant CMV epitopes derived from IE1 (LSEFCRVL and CRVLCCYVL) and UL28 (FRCPRRFCF), both antigens synthesized during immediate-early period of viral replication. Elicits a strong anti-viral CD8-positive T cell immune response that increases markedly with age. {ECO:0000269|PubMed:29312307}.; FUNCTION: ALLELE C*08:01: Presents viral epitopes derived from CMV UL83 (VVCAHELVC) and IAV M1 (GILGFVFTL), triggering CD8-positive T cell cytotoxic response. {ECO:0000269|PubMed:12947002, ECO:0000269|PubMed:24990997}.; FUNCTION: ALLELE C*12:02: Presents CMV epitope derived from UL83 (VAFTSHEHF) to CD8-positive T cells. {ECO:0000269|PubMed:12947002}.; FUNCTION: ALLELE C*15:02: Presents CMV epitope derived from UL83 CC (VVCAHELVC) to CD8-positive T cells, triggering T cell cytotoxic response. {ECO:0000269|PubMed:12947002}.	MISCELLANEOUS: [Isoform 2]: A transcript of allele C*16:01. This isoform lacks the transmembrane domain and is predicted to be a secreted protein. {ECO:0000305|PubMed:2914713}.	adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]	peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]; TAP binding [GO:0046977]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]; TAP binding [GO:0046977]; adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18420581, ECO:0000269|PubMed:20972337, ECO:0000269|PubMed:28649982}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:18420581}; Single-pass membrane protein {ECO:0000255}.
P10323	reviewed	ACRO_HUMAN	Acrosin (EC 3.4.21.10) [Cleaved into: Acrosin light chain; Acrosin heavy chain]	ACR ACRS	Homo sapiens (Human)	421	FUNCTION: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.		acrosome matrix dispersal [GO:0002077]; acrosome reaction [GO:0007340]; activation of adenylate cyclase activity [GO:0007190]; binding of sperm to zona pellucida [GO:0007339]; penetration of zona pellucida [GO:0007341]; response to steroid hormone [GO:0048545]; single fertilization [GO:0007338]	acrosomal matrix [GO:0043159]; extracellular region [GO:0005576]; Golgi-associated vesicle [GO:0005798]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	amidase activity [GO:0004040]; copper ion binding [GO:0005507]; DNA binding [GO:0003677]; fucose binding [GO:0042806]; mannose binding [GO:0005537]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; zinc ion binding [GO:0008270]	acrosomal matrix [GO:0043159]; extracellular region [GO:0005576]; Golgi-associated vesicle [GO:0005798]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; amidase activity [GO:0004040]; copper ion binding [GO:0005507]; DNA binding [GO:0003677]; fucose binding [GO:0042806]; mannose binding [GO:0005537]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; zinc ion binding [GO:0008270]; acrosome matrix dispersal [GO:0002077]; acrosome reaction [GO:0007340]; activation of adenylate cyclase activity [GO:0007190]; binding of sperm to zona pellucida [GO:0007339]; penetration of zona pellucida [GO:0007341]; response to steroid hormone [GO:0048545]; single fertilization [GO:0007338]	
P10398	reviewed	ARAF_HUMAN	Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)	ARAF ARAF1 PKS PKS2	Homo sapiens (Human)	606	FUNCTION: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}.	MISCELLANEOUS: [Isoform 2]: Has a wider tissue distribution than isoform 1, and acts as dominant-negative antagonist. {ECO:0000305}.	MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; phosphorylation [GO:0016310]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein modification process [GO:0036211]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of TOR signaling [GO:0032006]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; phosphorylation [GO:0016310]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein modification process [GO:0036211]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of TOR signaling [GO:0032006]	
P10412	reviewed	H14_HUMAN	Histone H1.4 (Histone H1b) (Histone H1s-4)	H1-4 H1F4 HIST1H1E	Homo sapiens (Human)	219	FUNCTION: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.	MISCELLANEOUS: This variant accounts for 60% of histone H1.	chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]	heterochromatin [GO:0000792]; nucleosome [GO:0000786]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]	heterochromatin [GO:0000792]; nucleosome [GO:0000786]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]; chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Mainly localizes in heterochromatin. Dysplays a punctuate staining pattern in the nucleus.
P10415	reviewed	BCL2_HUMAN	Apoptosis regulator Bcl-2	BCL2	Homo sapiens (Human)	239	FUNCTION: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:21358617, PubMed:20889974). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:1508712, ECO:0000269|PubMed:17418785, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:8183370, ECO:0000303|PubMed:11368354}.		actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; axon regeneration [GO:0031103]; axonogenesis [GO:0007409]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell lineage commitment [GO:0002326]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; behavioral fear response [GO:0001662]; branching involved in ureteric bud morphogenesis [GO:0001658]; calcium ion transport into cytosol [GO:0060402]; CD8-positive, alpha-beta T cell lineage commitment [GO:0043375]; cell-cell adhesion [GO:0098609]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; cellular response to organic substance [GO:0071310]; cochlear nucleus development [GO:0021747]; defense response to virus [GO:0051607]; dendritic cell apoptotic process [GO:0097048]; digestive tract morphogenesis [GO:0048546]; DNA damage response [GO:0006974]; ear development [GO:0043583]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial cell apoptotic process [GO:1904019]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; female pregnancy [GO:0007565]; focal adhesion assembly [GO:0048041]; G1/S transition of mitotic cell cycle [GO:0000082]; gland morphogenesis [GO:0022612]; glomerulus development [GO:0032835]; hair follicle morphogenesis [GO:0031069]; hematopoietic stem cell differentiation [GO:0060218]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; lymphoid progenitor cell differentiation [GO:0002320]; male gonad development [GO:0008584]; melanin metabolic process [GO:0006582]; melanocyte differentiation [GO:0030318]; mesenchymal cell development [GO:0014031]; metanephros development [GO:0001656]; motor neuron apoptotic process [GO:0097049]; myeloid cell apoptotic process [GO:0033028]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of autophagy [GO:0010507]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular pH reduction [GO:0032848]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of retinal cell programmed cell death [GO:0046671]; negative regulation of T cell apoptotic process [GO:0070233]; neuron apoptotic process [GO:0051402]; neuron maturation [GO:0042551]; oocyte development [GO:0048599]; organ growth [GO:0035265]; ossification [GO:0001503]; osteoblast proliferation [GO:0033687]; ovarian follicle development [GO:0001541]; pigment granule organization [GO:0048753]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuron maturation [GO:0014042]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of smooth muscle cell migration [GO:0014911]; post-embryonic development [GO:0009791]; protein polyubiquitination [GO:0000209]; reactive oxygen species metabolic process [GO:0072593]; regulation of calcium ion transport [GO:0051924]; regulation of cell-matrix adhesion [GO:0001952]; regulation of gene expression [GO:0010468]; regulation of glycoprotein biosynthetic process [GO:0010559]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of nitrogen utilization [GO:0006808]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647]; regulation of transmembrane transporter activity [GO:0022898]; regulation of viral genome replication [GO:0045069]; release of cytochrome c from mitochondria [GO:0001836]; renal system process [GO:0003014]; response to amino acid [GO:0043200]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to iron ion [GO:0010039]; response to ischemia [GO:0002931]; response to nicotine [GO:0035094]; response to radiation [GO:0009314]; response to toxic substance [GO:0009636]; response to UV-B [GO:0010224]; response to xenobiotic stimulus [GO:0009410]; retinal cell programmed cell death [GO:0046666]; skeletal muscle fiber development [GO:0048741]; smooth muscle cell migration [GO:0014909]; spleen development [GO:0048536]; stem cell development [GO:0048864]; T cell apoptotic process [GO:0070231]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]	BAD-BCL-2 complex [GO:0097138]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; pore complex [GO:0046930]; protein-containing complex [GO:0032991]	BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; channel inhibitor activity [GO:0016248]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase binding [GO:0031625]	BAD-BCL-2 complex [GO:0097138]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; pore complex [GO:0046930]; protein-containing complex [GO:0032991]; BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; channel inhibitor activity [GO:0016248]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase binding [GO:0031625]; actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; axon regeneration [GO:0031103]; axonogenesis [GO:0007409]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell lineage commitment [GO:0002326]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; behavioral fear response [GO:0001662]; branching involved in ureteric bud morphogenesis [GO:0001658]; calcium ion transport into cytosol [GO:0060402]; CD8-positive, alpha-beta T cell lineage commitment [GO:0043375]; cell-cell adhesion [GO:0098609]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; cellular response to organic substance [GO:0071310]; cochlear nucleus development [GO:0021747]; defense response to virus [GO:0051607]; dendritic cell apoptotic process [GO:0097048]; digestive tract morphogenesis [GO:0048546]; DNA damage response [GO:0006974]; ear development [GO:0043583]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial cell apoptotic process [GO:1904019]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; female pregnancy [GO:0007565]; focal adhesion assembly [GO:0048041]; G1/S transition of mitotic cell cycle [GO:0000082]; gland morphogenesis [GO:0022612]; glomerulus development [GO:0032835]; hair follicle morphogenesis [GO:0031069]; hematopoietic stem cell differentiation [GO:0060218]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; lymphoid progenitor cell differentiation [GO:0002320]; male gonad development [GO:0008584]; melanin metabolic process [GO:0006582]; melanocyte differentiation [GO:0030318]; mesenchymal cell development [GO:0014031]; metanephros development [GO:0001656]; motor neuron apoptotic process [GO:0097049]; myeloid cell apoptotic process [GO:0033028]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of autophagy [GO:0010507]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular pH reduction [GO:0032848]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of retinal cell programmed cell death [GO:0046671]; negative regulation of T cell apoptotic process [GO:0070233]; neuron apoptotic process [GO:0051402]; neuron maturation [GO:0042551]; oocyte development [GO:0048599]; organ growth [GO:0035265]; ossification [GO:0001503]; osteoblast proliferation [GO:0033687]; ovarian follicle development [GO:0001541]; pigment granule organization [GO:0048753]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuron maturation [GO:0014042]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of smooth muscle cell migration [GO:0014911]; post-embryonic development [GO:0009791]; protein polyubiquitination [GO:0000209]; reactive oxygen species metabolic process [GO:0072593]; regulation of calcium ion transport [GO:0051924]; regulation of cell-matrix adhesion [GO:0001952]; regulation of gene expression [GO:0010468]; regulation of glycoprotein biosynthetic process [GO:0010559]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of nitrogen utilization [GO:0006808]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647]; regulation of transmembrane transporter activity [GO:0022898]; regulation of viral genome replication [GO:0045069]; release of cytochrome c from mitochondria [GO:0001836]; renal system process [GO:0003014]; response to amino acid [GO:0043200]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to iron ion [GO:0010039]; response to ischemia [GO:0002931]; response to nicotine [GO:0035094]; response to radiation [GO:0009314]; response to toxic substance [GO:0009636]; response to UV-B [GO:0010224]; response to xenobiotic stimulus [GO:0009410]; retinal cell programmed cell death [GO:0046666]; skeletal muscle fiber development [GO:0048741]; smooth muscle cell migration [GO:0014909]; spleen development [GO:0048536]; stem cell development [GO:0048864]; T cell apoptotic process [GO:0070231]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P10417}.
P10451	reviewed	OSTP_HUMAN	Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)	SPP1 BNSP OPN PSEC0156	Homo sapiens (Human)	314	FUNCTION: Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}.		androgen catabolic process [GO:0006710]; biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; cellular response to testosterone stimulus [GO:0071394]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; negative regulation of collateral sprouting of intact axon in response to injury [GO:0048685]; osteoblast differentiation [GO:0001649]; positive regulation of bone resorption [GO:0045780]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of estradiol secretion [GO:2000866]; response to macrophage colony-stimulating factor [GO:0036005]; response to steroid hormone [GO:0048545]; response to vitamin D [GO:0033280]	cell projection [GO:0042995]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]	cytokine activity [GO:0005125]; extracellular matrix binding [GO:0050840]; integrin binding [GO:0005178]; ion binding [GO:0043167]; small molecule binding [GO:0036094]	cell projection [GO:0042995]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; cytokine activity [GO:0005125]; extracellular matrix binding [GO:0050840]; integrin binding [GO:0005178]; ion binding [GO:0043167]; small molecule binding [GO:0036094]; androgen catabolic process [GO:0006710]; biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; cellular response to testosterone stimulus [GO:0071394]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; negative regulation of collateral sprouting of intact axon in response to injury [GO:0048685]; osteoblast differentiation [GO:0001649]; positive regulation of bone resorption [GO:0045780]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of estradiol secretion [GO:2000866]; response to macrophage colony-stimulating factor [GO:0036005]; response to steroid hormone [GO:0048545]; response to vitamin D [GO:0033280]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313}.
P10515	reviewed	ODP2_HUMAN	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)	DLAT DLTA	Homo sapiens (Human)	647	FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.		acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254]	dihydrolipoyllysine-residue acetyltransferase activity [GO:0004742]; identical protein binding [GO:0042802]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254]; dihydrolipoyllysine-residue acetyltransferase activity [GO:0004742]; identical protein binding [GO:0042802]; acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P10523	reviewed	ARRS_HUMAN	S-arrestin (48 kDa protein) (Retinal S-antigen) (S-AG) (Rod photoreceptor arrestin)	SAG	Homo sapiens (Human)	405	FUNCTION: Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (By similarity). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049). {ECO:0000250|UniProtKB:P08168, ECO:0000305|PubMed:9565049}.		cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor internalization [GO:0002031]; rhodopsin mediated signaling pathway [GO:0016056]	cytosol [GO:0005829]; membrane [GO:0016020]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	G protein-coupled receptor binding [GO:0001664]; opsin binding [GO:0002046]; phosphoprotein binding [GO:0051219]; protein phosphatase inhibitor activity [GO:0004864]	cytosol [GO:0005829]; membrane [GO:0016020]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; G protein-coupled receptor binding [GO:0001664]; opsin binding [GO:0002046]; phosphoprotein binding [GO:0051219]; protein phosphatase inhibitor activity [GO:0004864]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor internalization [GO:0002031]; rhodopsin mediated signaling pathway [GO:0016056]	SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:3720866}. Membrane {ECO:0000250|UniProtKB:P20443}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20443}. Note=Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity). Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes (PubMed:3720866). {ECO:0000250|UniProtKB:P08168, ECO:0000269|PubMed:3720866}.
P10586	reviewed	PTPRF_HUMAN	Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)	PTPRF LAR	Homo sapiens (Human)	1907	FUNCTION: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; FUNCTION: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.		cell adhesion [GO:0007155]; cell migration [GO:0016477]; negative regulation of receptor binding [GO:1900121]; neuron projection regeneration [GO:0031102]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of axon regeneration [GO:0048679]; synaptic membrane adhesion [GO:0099560]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]	extracellular exosome [GO:0070062]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	cell adhesion molecule binding [GO:0050839]; chondroitin sulfate proteoglycan binding [GO:0035373]; heparin binding [GO:0008201]; protein tyrosine phosphatase activity [GO:0004725]; protein-containing complex binding [GO:0044877]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	extracellular exosome [GO:0070062]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; chondroitin sulfate proteoglycan binding [GO:0035373]; heparin binding [GO:0008201]; protein tyrosine phosphatase activity [GO:0004725]; protein-containing complex binding [GO:0044877]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; negative regulation of receptor binding [GO:1900121]; neuron projection regeneration [GO:0031102]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of axon regeneration [GO:0048679]; synaptic membrane adhesion [GO:0099560]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P10588	reviewed	NR2F6_HUMAN	Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2)	NR2F6 EAR2 ERBAL2	Homo sapiens (Human)	404	FUNCTION: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}.		anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:18701084}.
P10589	reviewed	COT1_HUMAN	COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3)	NR2F1 EAR3 ERBAL3 TFCOUP1	Homo sapiens (Human)	423	FUNCTION: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:11682620}.		anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P10599	reviewed	THIO_HUMAN	Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)	TXN TRDX TRX TRX1	Homo sapiens (Human)	105	FUNCTION: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:2176490, PubMed:17182577, PubMed:19032234). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity (PubMed:16408020, PubMed:17606900). Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (PubMed:9108029, PubMed:11118054). {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:16408020, ECO:0000269|PubMed:17182577, ECO:0000269|PubMed:17606900, ECO:0000269|PubMed:19032234, ECO:0000269|PubMed:2176490, ECO:0000269|PubMed:9108029}.; FUNCTION: ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).		activation of protein kinase B activity [GO:0032148]; cell redox homeostasis [GO:0045454]; cellular detoxification of hydrogen peroxide [GO:0061692]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA binding [GO:0043388]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; response to nitric oxide [GO:0071731]; response to radiation [GO:0009314]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein homodimerization activity [GO:0042803]; protein-disulfide reductase (NAD(P)) activity [GO:0047134]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein homodimerization activity [GO:0042803]; protein-disulfide reductase (NAD(P)) activity [GO:0047134]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]; activation of protein kinase B activity [GO:0032148]; cell redox homeostasis [GO:0045454]; cellular detoxification of hydrogen peroxide [GO:0061692]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA binding [GO:0043388]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; response to nitric oxide [GO:0071731]; response to radiation [GO:0009314]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:9108029}. Cytoplasm {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:9108029}. Secreted {ECO:0000269|PubMed:1332947}. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947). {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:1332947, ECO:0000269|PubMed:9108029}.
P10600	reviewed	TGFB3_HUMAN	Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)]	TGFB3	Homo sapiens (Human)	412	FUNCTION: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. {ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202}.; FUNCTION: [Latency-associated peptide]: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity). {ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202, ECO:0000250|UniProtKB:P17125}.; FUNCTION: Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). {ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202, ECO:0000250|UniProtKB:P17125}.		cell-cell junction organization [GO:0045216]; detection of hypoxia [GO:0070483]; digestive tract development [GO:0048565]; embryonic neurocranium morphogenesis [GO:0048702]; face morphogenesis [GO:0060325]; female pregnancy [GO:0007565]; frontal suture morphogenesis [GO:0060364]; in utero embryonic development [GO:0001701]; inner ear development [GO:0048839]; lung alveolus development [GO:0048286]; mammary gland development [GO:0030879]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; odontogenesis [GO:0042476]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein secretion [GO:0050714]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to laminar fluid shear stress [GO:0034616]; response to progesterone [GO:0032570]; salivary gland morphogenesis [GO:0007435]; secondary palate development [GO:0062009]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterine wall breakdown [GO:0042704]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; T-tubule [GO:0030315]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; transforming growth factor beta binding [GO:0050431]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; T-tubule [GO:0030315]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; transforming growth factor beta binding [GO:0050431]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714]; cell-cell junction organization [GO:0045216]; detection of hypoxia [GO:0070483]; digestive tract development [GO:0048565]; embryonic neurocranium morphogenesis [GO:0048702]; face morphogenesis [GO:0060325]; female pregnancy [GO:0007565]; frontal suture morphogenesis [GO:0060364]; in utero embryonic development [GO:0001701]; inner ear development [GO:0048839]; lung alveolus development [GO:0048286]; mammary gland development [GO:0030879]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; odontogenesis [GO:0042476]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein secretion [GO:0050714]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to laminar fluid shear stress [GO:0034616]; response to progesterone [GO:0032570]; salivary gland morphogenesis [GO:0007435]; secondary palate development [GO:0062009]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterine wall breakdown [GO:0042704]	SUBCELLULAR LOCATION: [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137}.; SUBCELLULAR LOCATION: [Transforming growth factor beta-3]: Secreted {ECO:0000250|UniProtKB:P01137}.
P10606	reviewed	COX5B_HUMAN	Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb)	COX5B	Homo sapiens (Human)	129	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04037}.		cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; respiratory gaseous exchange by respiratory system [GO:0007585]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]	cytochrome-c oxidase activity [GO:0004129]; metal ion binding [GO:0046872]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; cytochrome-c oxidase activity [GO:0004129]; metal ion binding [GO:0046872]; cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Peripheral membrane protein {ECO:0000269|PubMed:30030519}; Matrix side {ECO:0000269|PubMed:30030519}.
P10619	reviewed	PPGB_HUMAN	Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]	CTSA PPGB	Homo sapiens (Human)	480	FUNCTION: Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins. {ECO:0000269|PubMed:1907282}.		intracellular protein transport [GO:0006886]; negative regulation of chaperone-mediated autophagy [GO:1904715]; proteolysis [GO:0006508]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of protein stability [GO:0031647]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]	carboxypeptidase activity [GO:0004180]; enzyme activator activity [GO:0008047]; serine-type carboxypeptidase activity [GO:0004185]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; carboxypeptidase activity [GO:0004180]; enzyme activator activity [GO:0008047]; serine-type carboxypeptidase activity [GO:0004185]; intracellular protein transport [GO:0006886]; negative regulation of chaperone-mediated autophagy [GO:1904715]; proteolysis [GO:0006508]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Lysosome.
P10620	reviewed	MGST1_HUMAN	Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I)	MGST1 GST12 MGST	Homo sapiens (Human)	155	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000250|UniProtKB:P08011}.		cellular response to lipid hydroperoxide [GO:0071449]; glutathione transport [GO:0034635]	azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]	glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]	azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; cellular response to lipid hydroperoxide [GO:0071449]; glutathione transport [GO:0034635]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P08011}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P08011}.
P10632	reviewed	CP2C8_HUMAN	Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase)	CYP2C8	Homo sapiens (Human)	490	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:7574697, PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond (PubMed:7574697, PubMed:15766564, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form (PubMed:11093772). Displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1) (PubMed:14559847). Plays a role in the oxidative metabolism of xenobiotics. It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol) (PubMed:26427316). {ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15766564, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:26427316, ECO:0000269|PubMed:7574697}.		epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; icosanoid biosynthetic process [GO:0046456]; lipid hydroxylation [GO:0002933]; long-chain fatty acid biosynthetic process [GO:0042759]; omega-hydroxylase P450 pathway [GO:0097267]; organic acid metabolic process [GO:0006082]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; caffeine oxidase activity [GO:0034875]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; caffeine oxidase activity [GO:0034875]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; icosanoid biosynthetic process [GO:0046456]; lipid hydroxylation [GO:0002933]; long-chain fatty acid biosynthetic process [GO:0042759]; omega-hydroxylase P450 pathway [GO:0097267]; organic acid metabolic process [GO:0006082]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
P10635	reviewed	CP2D6_HUMAN	Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase)	CYP2D6 CYP2DL1	Homo sapiens (Human)	497	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:19965576, PubMed:20972997). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:18698000, PubMed:21289075). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid (PubMed:10681376). Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:16352597, ECO:0000269|PubMed:18698000, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20972997, ECO:0000269|PubMed:21289075, ECO:0000269|PubMed:21576599}.		alkaloid catabolic process [GO:0009822]; alkaloid metabolic process [GO:0009820]; arachidonic acid metabolic process [GO:0019369]; cholesterol metabolic process [GO:0008203]; coumarin metabolic process [GO:0009804]; estrogen metabolic process [GO:0008210]; heterocycle metabolic process [GO:0046483]; isoquinoline alkaloid metabolic process [GO:0033076]; long-chain fatty acid biosynthetic process [GO:0042759]; monoterpenoid metabolic process [GO:0016098]; negative regulation of binding [GO:0051100]; negative regulation of cellular organofluorine metabolic process [GO:0090350]; oxidative demethylation [GO:0070989]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]	anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; alkaloid catabolic process [GO:0009822]; alkaloid metabolic process [GO:0009820]; arachidonic acid metabolic process [GO:0019369]; cholesterol metabolic process [GO:0008203]; coumarin metabolic process [GO:0009804]; estrogen metabolic process [GO:0008210]; heterocycle metabolic process [GO:0046483]; isoquinoline alkaloid metabolic process [GO:0033076]; long-chain fatty acid biosynthetic process [GO:0042759]; monoterpenoid metabolic process [GO:0016098]; negative regulation of binding [GO:0051100]; negative regulation of cellular organofluorine metabolic process [GO:0090350]; oxidative demethylation [GO:0070989]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:21576599}; Peripheral membrane protein.
P10636	reviewed	TAU_HUMAN	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	MAPT MAPTL MTBT1 TAU	Homo sapiens (Human)	758	FUNCTION: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; amyloid fibril formation [GO:1990000]; astrocyte activation [GO:0048143]; axon development [GO:0061564]; axonal transport [GO:0098930]; axonal transport of mitochondrion [GO:0019896]; cell-cell signaling [GO:0007267]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to heat [GO:0034605]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to reactive oxygen species [GO:0034614]; central nervous system neuron development [GO:0021954]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; generation of neurons [GO:0048699]; internal protein amino acid acetylation [GO:0006475]; intracellular distribution of mitochondria [GO:0048312]; learning or memory [GO:0007611]; memory [GO:0007613]; microglial cell activation [GO:0001774]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; negative regulation of establishment of protein localization to mitochondrion [GO:1903748]; negative regulation of gene expression [GO:0010629]; negative regulation of kinase activity [GO:0033673]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of tubulin deacetylation [GO:1904428]; neurofibrillary tangle assembly [GO:1902988]; neuron projection development [GO:0031175]; plus-end-directed organelle transport along microtubule [GO:0072386]; positive regulation of axon extension [GO:0045773]; positive regulation of diacylglycerol kinase activity [GO:1905689]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of protein localization [GO:1903829]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of superoxide anion generation [GO:0032930]; protein homooligomerization [GO:0051260]; protein polymerization [GO:0051258]; regulation of autophagy [GO:0010506]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cellular response to heat [GO:1900034]; regulation of chromosome organization [GO:0033044]; regulation of long-term synaptic depression [GO:1900452]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; regulation of mitochondrial fission [GO:0090140]; regulation of synaptic plasticity [GO:0048167]; response to lead ion [GO:0010288]; rRNA metabolic process [GO:0016072]; stress granule assembly [GO:0034063]; supramolecular fiber organization [GO:0097435]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]	axolemma [GO:0030673]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; glial cell projection [GO:0097386]; growth cone [GO:0030426]; main axon [GO:0044304]; membrane raft [GO:0045121]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; neurofibrillary tangle [GO:0097418]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear periphery [GO:0034399]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; somatodendritic compartment [GO:0036477]; tubulin complex [GO:0045298]	actin binding [GO:0003779]; apolipoprotein binding [GO:0034185]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; dynactin binding [GO:0034452]; enzyme binding [GO:0019899]; histone-dependent DNA binding [GO:0099077]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; lipoprotein particle binding [GO:0071813]; microtubule binding [GO:0008017]; microtubule lateral binding [GO:0099609]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol bisphosphate binding [GO:1902936]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; SH3 domain binding [GO:0017124]; single-stranded DNA binding [GO:0003697]	axolemma [GO:0030673]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; glial cell projection [GO:0097386]; growth cone [GO:0030426]; main axon [GO:0044304]; membrane raft [GO:0045121]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; neurofibrillary tangle [GO:0097418]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear periphery [GO:0034399]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; somatodendritic compartment [GO:0036477]; tubulin complex [GO:0045298]; actin binding [GO:0003779]; apolipoprotein binding [GO:0034185]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; dynactin binding [GO:0034452]; enzyme binding [GO:0019899]; histone-dependent DNA binding [GO:0099077]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; lipoprotein particle binding [GO:0071813]; microtubule binding [GO:0008017]; microtubule lateral binding [GO:0099609]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol bisphosphate binding [GO:1902936]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; SH3 domain binding [GO:0017124]; single-stranded DNA binding [GO:0003697]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; amyloid fibril formation [GO:1990000]; astrocyte activation [GO:0048143]; axon development [GO:0061564]; axonal transport [GO:0098930]; axonal transport of mitochondrion [GO:0019896]; cell-cell signaling [GO:0007267]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to heat [GO:0034605]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to reactive oxygen species [GO:0034614]; central nervous system neuron development [GO:0021954]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; generation of neurons [GO:0048699]; internal protein amino acid acetylation [GO:0006475]; intracellular distribution of mitochondria [GO:0048312]; learning or memory [GO:0007611]; memory [GO:0007613]; microglial cell activation [GO:0001774]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; negative regulation of establishment of protein localization to mitochondrion [GO:1903748]; negative regulation of gene expression [GO:0010629]; negative regulation of kinase activity [GO:0033673]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of tubulin deacetylation [GO:1904428]; neurofibrillary tangle assembly [GO:1902988]; neuron projection development [GO:0031175]; plus-end-directed organelle transport along microtubule [GO:0072386]; positive regulation of axon extension [GO:0045773]; positive regulation of diacylglycerol kinase activity [GO:1905689]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of protein localization [GO:1903829]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of superoxide anion generation [GO:0032930]; protein homooligomerization [GO:0051260]; protein polymerization [GO:0051258]; regulation of autophagy [GO:0010506]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cellular response to heat [GO:1900034]; regulation of chromosome organization [GO:0033044]; regulation of long-term synaptic depression [GO:1900452]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; regulation of mitochondrial fission [GO:0090140]; regulation of synaptic plasticity [GO:0048167]; response to lead ion [GO:0010288]; rRNA metabolic process [GO:0016072]; stress granule assembly [GO:0034063]; supramolecular fiber organization [GO:0097435]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10747907, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:26014385}. Cell membrane {ECO:0000269|PubMed:10747907}; Peripheral membrane protein {ECO:0000269|PubMed:10747907}; Cytoplasmic side {ECO:0000269|PubMed:10747907}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10747907}. Cell projection, axon {ECO:0000269|PubMed:10747907}. Cell projection, dendrite {ECO:0000269|PubMed:23666762}. Secreted {ECO:0000269|PubMed:32272059}. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907). Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). {ECO:0000269|PubMed:10747907, ECO:0000269|PubMed:32272059}.
P10643	reviewed	CO7_HUMAN	Complement component C7	C7	Homo sapiens (Human)	843	FUNCTION: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.		complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886]		extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]	SUBCELLULAR LOCATION: Secreted.
P10644	reviewed	KAP0_HUMAN	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)	PRKAR1A PKR1 PRKAR1 TSE1	Homo sapiens (Human)	381	FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:26405036}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cardiac muscle cell proliferation [GO:0060038]; cellular response to glucagon stimulus [GO:0071377]; intracellular signal transduction [GO:0035556]; mesoderm formation [GO:0001707]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; negative regulation of gene expression [GO:0010629]; positive regulation of insulin secretion [GO:0032024]; regulation of transcription by RNA polymerase II [GO:0006357]; sarcomere organization [GO:0045214]	cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; multivesicular body [GO:0005771]; neuromuscular junction [GO:0031594]; nucleotide-activated protein kinase complex [GO:0031588]; plasma membrane raft [GO:0044853]; protein-containing complex [GO:0032991]; sperm connecting piece [GO:0097224]	cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein domain specific binding [GO:0019904]; protein kinase A catalytic subunit binding [GO:0034236]; ubiquitin protein ligase binding [GO:0031625]	cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; multivesicular body [GO:0005771]; neuromuscular junction [GO:0031594]; nucleotide-activated protein kinase complex [GO:0031588]; plasma membrane raft [GO:0044853]; protein-containing complex [GO:0032991]; sperm connecting piece [GO:0097224]; cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein domain specific binding [GO:0019904]; protein kinase A catalytic subunit binding [GO:0034236]; ubiquitin protein ligase binding [GO:0031625]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cardiac muscle cell proliferation [GO:0060038]; cellular response to glucagon stimulus [GO:0071377]; intracellular signal transduction [GO:0035556]; mesoderm formation [GO:0001707]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; negative regulation of gene expression [GO:0010629]; positive regulation of insulin secretion [GO:0032024]; regulation of transcription by RNA polymerase II [GO:0006357]; sarcomere organization [GO:0045214]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23115245}.
P10645	reviewed	CMGA_HUMAN	Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor]	CHGA	Homo sapiens (Human)	457	FUNCTION: [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}.	MISCELLANEOUS: Binds calcium with a low-affinity.	adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation [GO:0086030]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; mast cell activation [GO:0045576]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; negative regulation of catecholamine secretion [GO:0033604]; negative regulation of insulin secretion [GO:0046676]; organelle organization [GO:0006996]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of dense core granule biogenesis [GO:2000707]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of relaxation of cardiac muscle [GO:1901899]; protein localization to secretory granule [GO:0033366]; regulation of blood pressure [GO:0008217]; regulation of the force of heart contraction [GO:0002026]	chromaffin granule [GO:0042583]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; perinuclear region of cytoplasm [GO:0048471]; secretory granule [GO:0030141]; transport vesicle [GO:0030133]		chromaffin granule [GO:0042583]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; perinuclear region of cytoplasm [GO:0048471]; secretory granule [GO:0030141]; transport vesicle [GO:0030133]; adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation [GO:0086030]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; mast cell activation [GO:0045576]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; negative regulation of catecholamine secretion [GO:0033604]; negative regulation of insulin secretion [GO:0046676]; organelle organization [GO:0006996]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of dense core granule biogenesis [GO:2000707]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of relaxation of cardiac muscle [GO:1901899]; protein localization to secretory granule [GO:0033366]; regulation of blood pressure [GO:0008217]; regulation of the force of heart contraction [GO:0002026]	SUBCELLULAR LOCATION: [Serpinin]: Secreted {ECO:0000250|UniProtKB:P26339}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P26339}. Note=Pyroglutaminated serpinin localizes to secretory vesicle. {ECO:0000250|UniProtKB:P26339}.; SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P10354}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle {ECO:0000250|UniProtKB:P10354}. Secreted {ECO:0000269|PubMed:25326458}. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. In pituitary gonadotropes, located in large secretory granules. {ECO:0000250|UniProtKB:P10354}.
P10646	reviewed	TFPI1_HUMAN	Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI)	TFPI LACI TFPI1	Homo sapiens (Human)	304	FUNCTION: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.	MISCELLANEOUS: [Isoform Beta]: GPI-anchored. {ECO:0000305}.	blood coagulation [GO:0007596]; cellular response to steroid hormone stimulus [GO:0071383]; negative regulation of blood coagulation [GO:0030195]	caveola [GO:0005901]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]	caveola [GO:0005901]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; blood coagulation [GO:0007596]; cellular response to steroid hormone stimulus [GO:0071383]; negative regulation of blood coagulation [GO:0030195]	SUBCELLULAR LOCATION: [Isoform Alpha]: Secreted.; SUBCELLULAR LOCATION: [Isoform Beta]: Microsome membrane {ECO:0000269|PubMed:22144186}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:22144186}.
P10696	reviewed	PPBN_HUMAN	Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like)	ALPG ALPPL ALPPL2	Homo sapiens (Human)	532	FUNCTION: Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}.	MISCELLANEOUS: In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non-specific (liver/bone/kidney) (ALPL/TNAP). {ECO:0000305}.	dephosphorylation [GO:0016311]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	alkaline phosphatase activity [GO:0004035]; metal ion binding [GO:0046872]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; alkaline phosphatase activity [GO:0004035]; metal ion binding [GO:0046872]; dephosphorylation [GO:0016311]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
P10720	reviewed	PF4V_HUMAN	Platelet factor 4 variant (C-X-C motif chemokine 4 variant) (CXCL4L1) (PF4alt) (PF4var1) [Cleaved into: Platelet factor 4 variant(4-74); Platelet factor 4 variant(5-74); Platelet factor 4 variant(6-74)]	PF4V1 CXCL4V1 SCYB4V1	Homo sapiens (Human)	104	FUNCTION: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro). {ECO:0000269|PubMed:15459074}.	MISCELLANEOUS: Binding to heparin is much weaker than in the close homolog PF4/CXCL4.	antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]	extracellular space [GO:0005615]	chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; heparin binding [GO:0008201]	extracellular space [GO:0005615]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; heparin binding [GO:0008201]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]	SUBCELLULAR LOCATION: Secreted.
P10721	reviewed	KIT_HUMAN	Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)	KIT SCFR	Homo sapiens (Human)	976	FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}.	MISCELLANEOUS: Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to determine which are directly phosphorylated by KIT under in vivo conditions.	actin cytoskeleton organization [GO:0030036]; B cell differentiation [GO:0030183]; cell chemotaxis [GO:0060326]; cellular response to thyroid hormone stimulus [GO:0097067]; cytokine-mediated signaling pathway [GO:0019221]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; digestive tract development [GO:0048565]; ectopic germ cell programmed cell death [GO:0035234]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation [GO:0050673]; erythrocyte differentiation [GO:0030218]; erythropoietin-mediated signaling pathway [GO:0038162]; Fc receptor signaling pathway [GO:0038093]; germ cell migration [GO:0008354]; glycosphingolipid metabolic process [GO:0006687]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell migration [GO:0035701]; hemopoiesis [GO:0030097]; immature B cell differentiation [GO:0002327]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; Kit signaling pathway [GO:0038109]; lamellipodium assembly [GO:0030032]; lymphoid progenitor cell differentiation [GO:0002320]; male gonad development [GO:0008584]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; mast cell proliferation [GO:0070662]; megakaryocyte development [GO:0035855]; melanocyte adhesion [GO:0097326]; melanocyte differentiation [GO:0030318]; melanocyte migration [GO:0097324]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of developmental process [GO:0051093]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reproductive process [GO:2000242]; ovarian follicle development [GO:0001541]; pigmentation [GO:0043473]; positive regulation of cell migration [GO:0030335]; positive regulation of colon smooth muscle contraction [GO:1904343]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of pyloric antrum smooth muscle contraction [GO:0120072]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of small intestine smooth muscle contraction [GO:1904349]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; protein autophosphorylation [GO:0046777]; regulation of bile acid metabolic process [GO:1904251]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; response to cadmium ion [GO:0046686]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]; T cell differentiation [GO:0030217]; tongue development [GO:0043586]; visual learning [GO:0008542]	acrosomal vesicle [GO:0001669]; cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; SH2 domain binding [GO:0042169]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	acrosomal vesicle [GO:0001669]; cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; SH2 domain binding [GO:0042169]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; actin cytoskeleton organization [GO:0030036]; B cell differentiation [GO:0030183]; cell chemotaxis [GO:0060326]; cellular response to thyroid hormone stimulus [GO:0097067]; cytokine-mediated signaling pathway [GO:0019221]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; digestive tract development [GO:0048565]; ectopic germ cell programmed cell death [GO:0035234]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation [GO:0050673]; erythrocyte differentiation [GO:0030218]; erythropoietin-mediated signaling pathway [GO:0038162]; Fc receptor signaling pathway [GO:0038093]; germ cell migration [GO:0008354]; glycosphingolipid metabolic process [GO:0006687]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell migration [GO:0035701]; hemopoiesis [GO:0030097]; immature B cell differentiation [GO:0002327]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; Kit signaling pathway [GO:0038109]; lamellipodium assembly [GO:0030032]; lymphoid progenitor cell differentiation [GO:0002320]; male gonad development [GO:0008584]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; mast cell proliferation [GO:0070662]; megakaryocyte development [GO:0035855]; melanocyte adhesion [GO:0097326]; melanocyte differentiation [GO:0030318]; melanocyte migration [GO:0097324]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of developmental process [GO:0051093]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reproductive process [GO:2000242]; ovarian follicle development [GO:0001541]; pigmentation [GO:0043473]; positive regulation of cell migration [GO:0030335]; positive regulation of colon smooth muscle contraction [GO:1904343]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of pyloric antrum smooth muscle contraction [GO:0120072]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of small intestine smooth muscle contraction [GO:1904349]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; protein autophosphorylation [GO:0046777]; regulation of bile acid metabolic process [GO:1904251]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; response to cadmium ion [GO:0046686]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]; T cell differentiation [GO:0030217]; tongue development [GO:0043586]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:20601678}. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head. {ECO:0000269|PubMed:20601678}.
P10745	reviewed	RET3_HUMAN	Retinol-binding protein 3 (Interphotoreceptor retinoid-binding protein) (IRBP) (Interstitial retinol-binding protein)	RBP3	Homo sapiens (Human)	1247	FUNCTION: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.		lipid metabolic process [GO:0006629]; proteolysis [GO:0006508]; retinoid metabolic process [GO:0001523]; visual perception [GO:0007601]	cone matrix sheath [GO:0090658]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]	retinal binding [GO:0016918]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]; serine-type peptidase activity [GO:0008236]	cone matrix sheath [GO:0090658]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; retinal binding [GO:0016918]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]; serine-type peptidase activity [GO:0008236]; lipid metabolic process [GO:0006629]; proteolysis [GO:0006508]; retinoid metabolic process [GO:0001523]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
P10746	reviewed	HEM4_HUMAN	Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase)	UROS	Homo sapiens (Human)	265	FUNCTION: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins (PubMed:11689424, PubMed:18004775). Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). {ECO:0000269|PubMed:11689424, ECO:0000269|PubMed:18004775}.		cellular response to amine stimulus [GO:0071418]; cellular response to arsenic-containing substance [GO:0071243]; heme biosynthetic process [GO:0006783]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to platinum ion [GO:0070541]; uroporphyrinogen III biosynthetic process [GO:0006780]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	folic acid binding [GO:0005542]; uroporphyrinogen-III synthase activity [GO:0004852]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; folic acid binding [GO:0005542]; uroporphyrinogen-III synthase activity [GO:0004852]; cellular response to amine stimulus [GO:0071418]; cellular response to arsenic-containing substance [GO:0071243]; heme biosynthetic process [GO:0006783]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to platinum ion [GO:0070541]; uroporphyrinogen III biosynthetic process [GO:0006780]	
P10747	reviewed	CD28_HUMAN	T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28)	CD28	Homo sapiens (Human)	220	FUNCTION: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). {ECO:0000269|PubMed:15067037, ECO:0000269|PubMed:8617933}.		apoptotic signaling pathway [GO:0097190]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell surface receptor signaling pathway [GO:0007166]; humoral immune response [GO:0006959]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative thymic T cell selection [GO:0045060]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cytokine production [GO:0001819]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of viral genome replication [GO:0045070]; regulation of regulatory T cell differentiation [GO:0045589]; regulatory T cell differentiation [GO:0045066]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; transcription by RNA polymerase II [GO:0006366]	cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]	coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]	cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; apoptotic signaling pathway [GO:0097190]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell surface receptor signaling pathway [GO:0007166]; humoral immune response [GO:0006959]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative thymic T cell selection [GO:0045060]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cytokine production [GO:0001819]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of viral genome replication [GO:0045070]; regulation of regulatory T cell differentiation [GO:0045589]; regulatory T cell differentiation [GO:0045066]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell surface {ECO:0000269|PubMed:15067037}.
P10767	reviewed	FGF6_HUMAN	Fibroblast growth factor 6 (FGF-6) (Heparin secretory-transforming protein 2) (HST-2) (HSTF-2) (Heparin-binding growth factor 6) (HBGF-6)	FGF6 HST2 HSTF2	Homo sapiens (Human)	208	FUNCTION: Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. {ECO:0000269|PubMed:8663044}.		angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; fibroblast growth factor receptor signaling pathway [GO:0008543]; myoblast differentiation [GO:0045445]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; sarcolemma [GO:0042383]	fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; sarcolemma [GO:0042383]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; fibroblast growth factor receptor signaling pathway [GO:0008543]; myoblast differentiation [GO:0045445]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P10768	reviewed	ESTD_HUMAN	S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56)	ESD	Homo sapiens (Human)	282	FUNCTION: Serine hydrolase involved in the detoxification of formaldehyde. {ECO:0000269|PubMed:3770744, ECO:0000269|PubMed:4768551}.		formaldehyde catabolic process [GO:0046294]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]	carboxylic ester hydrolase activity [GO:0052689]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; S-formylglutathione hydrolase activity [GO:0018738]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; carboxylic ester hydrolase activity [GO:0052689]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; S-formylglutathione hydrolase activity [GO:0018738]; formaldehyde catabolic process [GO:0046294]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle.
P10809	reviewed	CH60_HUMAN	60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein)	HSPD1 HSP60	Homo sapiens (Human)	573	FUNCTION: Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}.		'de novo' protein folding [GO:0006458]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic mitochondrial changes [GO:0008637]; B cell activation [GO:0042113]; B cell proliferation [GO:0042100]; biological process involved in interaction with symbiont [GO:0051702]; cellular response to interleukin-7 [GO:0098761]; chaperone-mediated protein complex assembly [GO:0051131]; isotype switching to IgG isotypes [GO:0048291]; mitochondrial unfolded protein response [GO:0034514]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage activation [GO:0043032]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; positive regulation of type II interferon production [GO:0032729]; protein folding [GO:0006457]; protein import into mitochondrial intermembrane space [GO:0045041]; protein maturation [GO:0051604]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; response to cold [GO:0009409]; response to unfolded protein [GO:0006986]; T cell activation [GO:0042110]	cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; coated vesicle [GO:0030135]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lipopolysaccharide receptor complex [GO:0046696]; membrane [GO:0016020]; migrasome [GO:0140494]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; sperm midpiece [GO:0097225]; sperm plasma membrane [GO:0097524]	apolipoprotein A-I binding [GO:0034186]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; DNA replication origin binding [GO:0003688]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; high-density lipoprotein particle binding [GO:0008035]; isomerase activity [GO:0016853]; lipopolysaccharide binding [GO:0001530]; p53 binding [GO:0002039]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; coated vesicle [GO:0030135]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lipopolysaccharide receptor complex [GO:0046696]; membrane [GO:0016020]; migrasome [GO:0140494]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; sperm midpiece [GO:0097225]; sperm plasma membrane [GO:0097524]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; DNA replication origin binding [GO:0003688]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; high-density lipoprotein particle binding [GO:0008035]; isomerase activity [GO:0016853]; lipopolysaccharide binding [GO:0001530]; p53 binding [GO:0002039]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; 'de novo' protein folding [GO:0006458]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic mitochondrial changes [GO:0008637]; B cell activation [GO:0042113]; B cell proliferation [GO:0042100]; biological process involved in interaction with symbiont [GO:0051702]; cellular response to interleukin-7 [GO:0098761]; chaperone-mediated protein complex assembly [GO:0051131]; isotype switching to IgG isotypes [GO:0048291]; mitochondrial unfolded protein response [GO:0034514]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage activation [GO:0043032]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; positive regulation of type II interferon production [GO:0032729]; protein folding [GO:0006457]; protein import into mitochondrial intermembrane space [GO:0045041]; protein maturation [GO:0051604]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; response to cold [GO:0009409]; response to unfolded protein [GO:0006986]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P10826	reviewed	RARB_HUMAN	Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon)	RARB HAP NR1B2	Homo sapiens (Human)	455	FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (PubMed:12554770). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (PubMed:29021580). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). {ECO:0000250|UniProtKB:P22605, ECO:0000269|PubMed:12554770, ECO:0000269|PubMed:29021580}.		apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; embryonic digestive tract development [GO:0048566]; embryonic eye morphogenesis [GO:0048048]; embryonic hindlimb morphogenesis [GO:0035116]; glandular epithelial cell development [GO:0002068]; growth plate cartilage development [GO:0003417]; hormone-mediated signaling pathway [GO:0009755]; multicellular organism growth [GO:0035264]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural precursor cell proliferation [GO:0061351]; neurogenesis [GO:0022008]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myelination [GO:0031641]; retinoic acid receptor signaling pathway [GO:0048384]; signal transduction [GO:0007165]; stem cell proliferation [GO:0072089]; striatum development [GO:0021756]; ureteric bud development [GO:0001657]; ventricular cardiac muscle cell differentiation [GO:0055012]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; embryonic digestive tract development [GO:0048566]; embryonic eye morphogenesis [GO:0048048]; embryonic hindlimb morphogenesis [GO:0035116]; glandular epithelial cell development [GO:0002068]; growth plate cartilage development [GO:0003417]; hormone-mediated signaling pathway [GO:0009755]; multicellular organism growth [GO:0035264]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural precursor cell proliferation [GO:0061351]; neurogenesis [GO:0022008]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myelination [GO:0031641]; retinoic acid receptor signaling pathway [GO:0048384]; signal transduction [GO:0007165]; stem cell proliferation [GO:0072089]; striatum development [GO:0021756]; ureteric bud development [GO:0001657]; ventricular cardiac muscle cell differentiation [GO:0055012]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28167758}. Cytoplasm {ECO:0000269|PubMed:28167758}.; SUBCELLULAR LOCATION: [Isoform Beta-1]: Nucleus.; SUBCELLULAR LOCATION: [Isoform Beta-2]: Nucleus.; SUBCELLULAR LOCATION: [Isoform Beta-4]: Cytoplasm.
P10827	reviewed	THA_HUMAN	Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)	THRA EAR7 ERBA1 NR1A1 THRA1 THRA2	Homo sapiens (Human)	490	FUNCTION: [Isoform Alpha-1]: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. {ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:19926848}.; FUNCTION: [Isoform Alpha-2]: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. {ECO:0000269|PubMed:8910441}.	MISCELLANEOUS: [Isoform Alpha-2]: Does not bind thyroid hormone T3. {ECO:0000305|PubMed:20078863}.	cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; erythrocyte differentiation [GO:0030218]; female courtship behavior [GO:0008050]; hormone-mediated signaling pathway [GO:0009755]; learning or memory [GO:0007611]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of DNA-templated transcription initiation [GO:2000143]; negative regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0017055]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification [GO:0001503]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of female receptivity [GO:0045925]; positive regulation of thyroid hormone mediated signaling pathway [GO:0002157]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart contraction [GO:0008016]; regulation of lipid catabolic process [GO:0050994]; regulation of myeloid cell apoptotic process [GO:0033032]; regulation of thyroid hormone mediated signaling pathway [GO:0002155]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cold [GO:0009409]; retinoic acid receptor signaling pathway [GO:0048384]; thyroid gland development [GO:0030878]; thyroid hormone mediated signaling pathway [GO:0002154]; transcription by RNA polymerase II [GO:0006366]; type I pneumocyte differentiation [GO:0060509]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; general transcription initiation factor binding [GO:0140296]; nuclear receptor activity [GO:0004879]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; TBP-class protein binding [GO:0017025]; thyroid hormone binding [GO:0070324]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; general transcription initiation factor binding [GO:0140296]; nuclear receptor activity [GO:0004879]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; TBP-class protein binding [GO:0017025]; thyroid hormone binding [GO:0070324]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; erythrocyte differentiation [GO:0030218]; female courtship behavior [GO:0008050]; hormone-mediated signaling pathway [GO:0009755]; learning or memory [GO:0007611]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of DNA-templated transcription initiation [GO:2000143]; negative regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0017055]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification [GO:0001503]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of female receptivity [GO:0045925]; positive regulation of thyroid hormone mediated signaling pathway [GO:0002157]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart contraction [GO:0008016]; regulation of lipid catabolic process [GO:0050994]; regulation of myeloid cell apoptotic process [GO:0033032]; regulation of thyroid hormone mediated signaling pathway [GO:0002155]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cold [GO:0009409]; retinoic acid receptor signaling pathway [GO:0048384]; thyroid gland development [GO:0030878]; thyroid hormone mediated signaling pathway [GO:0002154]; transcription by RNA polymerase II [GO:0006366]; type I pneumocyte differentiation [GO:0060509]	SUBCELLULAR LOCATION: Nucleus.; SUBCELLULAR LOCATION: [Isoform Alpha-2]: Cytoplasm {ECO:0000250|UniProtKB:P63058}. Nucleus {ECO:0000250|UniProtKB:P63058}. Note=When overexpressed found in the cytoplasm where it colocalizes with TACC1. {ECO:0000250|UniProtKB:P63058}.
P10828	reviewed	THB_HUMAN	Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)	THRB ERBA2 NR1A2 THR1	Homo sapiens (Human)	461	FUNCTION: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. {ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:16781732, ECO:0000269|PubMed:17418816, ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:18798561, ECO:0000269|PubMed:19926848}.		cell differentiation [GO:0030154]; cellular response to thyroid hormone stimulus [GO:0097067]; DNA-templated transcription [GO:0006351]; female courtship behavior [GO:0008050]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of female receptivity [GO:0007621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of thyroid hormone mediated signaling pathway [GO:0002157]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart contraction [GO:0008016]; retinal cone cell apoptotic process [GO:0097474]; retinal cone cell development [GO:0046549]; retinoic acid receptor signaling pathway [GO:0048384]; sensory perception of sound [GO:0007605]; thyroid hormone mediated signaling pathway [GO:0002154]; type I pneumocyte differentiation [GO:0060509]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; thyroid hormone binding [GO:0070324]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; thyroid hormone binding [GO:0070324]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; cellular response to thyroid hormone stimulus [GO:0097067]; DNA-templated transcription [GO:0006351]; female courtship behavior [GO:0008050]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of female receptivity [GO:0007621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of thyroid hormone mediated signaling pathway [GO:0002157]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart contraction [GO:0008016]; retinal cone cell apoptotic process [GO:0097474]; retinal cone cell development [GO:0046549]; retinoic acid receptor signaling pathway [GO:0048384]; sensory perception of sound [GO:0007605]; thyroid hormone mediated signaling pathway [GO:0002154]; type I pneumocyte differentiation [GO:0060509]	SUBCELLULAR LOCATION: Nucleus.
P10909	reviewed	CLUS_HUMAN	Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)]	CLU APOJ CLI KUB1 AAG4	Homo sapiens (Human)	449	FUNCTION: [Isoform 1]: Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed:11123922, PubMed:12176985, PubMed:17260971, PubMed:19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed:12047389, PubMed:17412999, PubMed:17407782). Does not require ATP (PubMed:11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed:11123922). Does not refold proteins by itself (PubMed:11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed:21505792). Protects cells against apoptosis and against cytolysis by complement (PubMed:2780565). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed:20068069). Modulates NF-kappa-B transcriptional activity (PubMed:12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed:16113678, PubMed:17689225). Plays a role in the regulation of cell proliferation (PubMed:19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed:22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). {ECO:0000250|UniProtKB:P05371, ECO:0000250|UniProtKB:Q06890, ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389, ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782, ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225, ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339, ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069, ECO:0000269|PubMed:21505792, ECO:0000269|PubMed:22689054, ECO:0000269|PubMed:24073260, ECO:0000269|PubMed:2780565}.; FUNCTION: [Isoform 6]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. {ECO:0000269|PubMed:24073260}.; FUNCTION: [Isoform 4]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed:21567405). {ECO:0000269|PubMed:21567405, ECO:0000269|PubMed:24073260}.	MISCELLANEOUS: [Isoform 1]: Major isoform. Major isoform. Detectable at protein level in stressed and unstressed cells (PubMed:24073260). {ECO:0000269|PubMed:24073260}.; MISCELLANEOUS: [Isoform 4]: Minor isoform that has been detected in a breast cancer cell line, but not in any other tissues or cell lines (PubMed:12551933). Not glycosylated. Not detected in unstressed cells. Detectable at low level in stressed cells (PubMed:24073260). {ECO:0000269|PubMed:24073260, ECO:0000303|PubMed:12551933}.; MISCELLANEOUS: [Isoform 6]: Translated from an unconventional translation initiation site CTG (PubMed:24073260). Not glycosylated (PubMed:24073260). Not detected in unstressed cells. Detectable at low level in stressed cells (PubMed:24073260). {ECO:0000269|PubMed:24073260}.	cell morphogenesis [GO:0000902]; central nervous system myelin maintenance [GO:0032286]; chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; immune complex clearance [GO:0002434]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; lipid metabolic process [GO:0006629]; microglial cell activation [GO:0001774]; microglial cell proliferation [GO:0061518]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neurofibrillary tangle assembly [GO:1902998]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of tau-protein kinase activity [GO:1902949]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein import [GO:0017038]; protein stabilization [GO:0050821]; protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740]; regulation of amyloid-beta clearance [GO:1900221]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of neuronal signal transduction [GO:1902847]; release of cytochrome c from mitochondria [GO:0001836]; response to misfolded protein [GO:0051788]; response to virus [GO:0009615]; reverse cholesterol transport [GO:0043691]	apical dendrite [GO:0097440]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; chromaffin granule [GO:0042583]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neurofibrillary tangle [GO:0097418]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum lumen [GO:0099020]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule lumen [GO:0031093]; protein-containing complex [GO:0032991]; spherical high-density lipoprotein particle [GO:0034366]; synapse [GO:0045202]	amyloid-beta binding [GO:0001540]; low-density lipoprotein particle receptor binding [GO:0050750]; misfolded protein binding [GO:0051787]; protein carrier chaperone [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; signaling receptor binding [GO:0005102]; tau protein binding [GO:0048156]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	apical dendrite [GO:0097440]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; chromaffin granule [GO:0042583]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neurofibrillary tangle [GO:0097418]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum lumen [GO:0099020]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule lumen [GO:0031093]; protein-containing complex [GO:0032991]; spherical high-density lipoprotein particle [GO:0034366]; synapse [GO:0045202]; amyloid-beta binding [GO:0001540]; low-density lipoprotein particle receptor binding [GO:0050750]; misfolded protein binding [GO:0051787]; protein carrier chaperone [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; signaling receptor binding [GO:0005102]; tau protein binding [GO:0048156]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; cell morphogenesis [GO:0000902]; central nervous system myelin maintenance [GO:0032286]; chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; immune complex clearance [GO:0002434]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; lipid metabolic process [GO:0006629]; microglial cell activation [GO:0001774]; microglial cell proliferation [GO:0061518]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neurofibrillary tangle assembly [GO:1902998]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of tau-protein kinase activity [GO:1902949]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein import [GO:0017038]; protein stabilization [GO:0050821]; protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740]; regulation of amyloid-beta clearance [GO:1900221]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of neuronal signal transduction [GO:1902847]; release of cytochrome c from mitochondria [GO:0001836]; response to misfolded protein [GO:0051788]; response to virus [GO:0009615]; reverse cholesterol transport [GO:0043691]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17451556, ECO:0000269|PubMed:2387851, ECO:0000269|PubMed:24073260, ECO:0000269|PubMed:2780565, ECO:0000269|PubMed:3154963, ECO:0000269|PubMed:8292612, ECO:0000269|PubMed:8328966}. Note=Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. {ECO:0000269|PubMed:17451556}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:24073260}. Note=Keeps cytoplasmic localization in stressed and unstressed cell. {ECO:0000269|PubMed:24073260}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000269|PubMed:24073260}. Note=Keeps cytoplasmic localization in stressed and unstressed cell. {ECO:0000269|PubMed:24073260}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12551933, ECO:0000269|PubMed:19137541}. Cytoplasm {ECO:0000269|PubMed:12551933, ECO:0000269|PubMed:17689225, ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:20068069, ECO:0000269|PubMed:22689054, ECO:0000269|PubMed:24073260}. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:17689225}. Cytoplasm, cytosol {ECO:0000269|PubMed:17451556, ECO:0000269|PubMed:22689054, ECO:0000269|PubMed:24073260}. Microsome {ECO:0000269|PubMed:22689054}. Endoplasmic reticulum {ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:22689054}. Mitochondrion {ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:22689054}. Mitochondrion membrane {ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:17689225}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P05371}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250}. Note=Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress (PubMed:17451556). Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (PubMed:20068069). Detected at the mitochondrion membrane upon induction of apoptosis (PubMed:17689225). Under ER stress, a immaturely glycosylated pre-secreted form retrotranslocates from the endoplasmic reticulum (ER)-Golgi network to the cytoplasm to localize in the mitochondria through HSPA5 interaction (PubMed:22689054). ER stress reduces secretion (PubMed:22689054). Under the stress, minor amounts of non-secreted forms accumulate in cytoplasm (PubMed:24073260, PubMed:22689054, PubMed:17451556). Non-secreted forms emerge mainly from failed translocation, alternative splicing or non-canonical initiation start codon (PubMed:24073260, PubMed:12551933). {ECO:0000269|PubMed:12551933, ECO:0000269|PubMed:17451556, ECO:0000269|PubMed:17689225, ECO:0000269|PubMed:20068069, ECO:0000269|PubMed:22689054, ECO:0000269|PubMed:24073260}.
P10911	reviewed	MCF2_HUMAN	Proto-oncogene DBL (Proto-oncogene MCF-2) [Cleaved into: MCF2-transforming protein; DBL-transforming protein]	MCF2 DBL	Homo sapiens (Human)	925	FUNCTION: Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.		cellular response to leukemia inhibitory factor [GO:1990830]; dendrite development [GO:0016358]; intracellular signal transduction [GO:0035556]; negative regulation of axonogenesis [GO:0050771]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020]; guanyl-nucleotide exchange factor activity [GO:0005085]; cellular response to leukemia inhibitory factor [GO:1990830]; dendrite development [GO:0016358]; intracellular signal transduction [GO:0035556]; negative regulation of axonogenesis [GO:0050771]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15157669}.; SUBCELLULAR LOCATION: [Isoform 1]: Membrane.; SUBCELLULAR LOCATION: [Isoform 3]: Membrane. Note=Colocalizes with CDC42 to plasma membrane.
P10912	reviewed	GHR_HUMAN	Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]	GHR	Homo sapiens (Human)	638	FUNCTION: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). {ECO:0000250}.; FUNCTION: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.; FUNCTION: Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.	MISCELLANEOUS: [Isoform 4]: Arises by species-specific retrovirus-mediated alternative splice mimicry. {ECO:0000305}.	cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to hormone stimulus [GO:0032870]; cellular response to insulin stimulus [GO:0032869]; cytokine-mediated signaling pathway [GO:0019221]; endocytosis [GO:0006897]; growth hormone receptor signaling pathway [GO:0060396]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; insulin-like growth factor receptor signaling pathway [GO:0048009]; positive regulation of cell differentiation [GO:0045597]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor internalization [GO:0031623]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of multicellular organism growth [GO:0040014]; regulation of response to nutrient levels [GO:0032107]; response to cycloheximide [GO:0046898]; response to estradiol [GO:0032355]; response to food [GO:0032094]; response to glucocorticoid [GO:0051384]; response to gravity [GO:0009629]; response to interleukin-1 [GO:0070555]; taurine metabolic process [GO:0019530]	cell surface [GO:0009986]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth hormone receptor complex [GO:0070195]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; growth hormone receptor activity [GO:0004903]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; peptide hormone binding [GO:0017046]; proline-rich region binding [GO:0070064]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SH2 domain binding [GO:0042169]	cell surface [GO:0009986]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth hormone receptor complex [GO:0070195]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; growth hormone receptor activity [GO:0004903]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; peptide hormone binding [GO:0017046]; proline-rich region binding [GO:0070064]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SH2 domain binding [GO:0042169]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to hormone stimulus [GO:0032870]; cellular response to insulin stimulus [GO:0032869]; cytokine-mediated signaling pathway [GO:0019221]; endocytosis [GO:0006897]; growth hormone receptor signaling pathway [GO:0060396]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; insulin-like growth factor receptor signaling pathway [GO:0048009]; positive regulation of cell differentiation [GO:0045597]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor internalization [GO:0031623]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of multicellular organism growth [GO:0040014]; regulation of response to nutrient levels [GO:0032107]; response to cycloheximide [GO:0046898]; response to estradiol [GO:0032355]; response to food [GO:0032094]; response to glucocorticoid [GO:0051384]; response to gravity [GO:0009629]; response to interleukin-1 [GO:0070555]; taurine metabolic process [GO:0019530]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Note=Remains fixed to the cell membrane and is not internalized.; SUBCELLULAR LOCATION: [Growth hormone-binding protein]: Secreted. Note=Complexed to a substantial fraction of circulating GH. {ECO:0000250}.
P10914	reviewed	IRF1_HUMAN	Interferon regulatory factor 1 (IRF-1)	IRF1	Homo sapiens (Human)	325	FUNCTION: Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195, PubMed:32385160). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:21389130, PubMed:22367195). Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters (PubMed:32385160). Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as GBP2, GBP5 and NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (PubMed:18641303, PubMed:22200613). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (PubMed:15509808, PubMed:18084608). Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (PubMed:20049431). {ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:15509808, ECO:0000269|PubMed:17516545, ECO:0000269|PubMed:17942705, ECO:0000269|PubMed:18084608, ECO:0000269|PubMed:18497060, ECO:0000269|PubMed:18641303, ECO:0000269|PubMed:19404407, ECO:0000269|PubMed:19851330, ECO:0000269|PubMed:21389130, ECO:0000269|PubMed:22200613, ECO:0000269|PubMed:22367195, ECO:0000269|PubMed:32385160, ECO:0000303|PubMed:11244049, ECO:0000303|PubMed:11846971, ECO:0000303|PubMed:11846974, ECO:0000303|PubMed:16932750, ECO:0000303|PubMed:20049431}.	MISCELLANEOUS: Deletion or rearrangement of IRF1 are found in preleukemic myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML).	apoptotic process [GO:0006915]; CD8-positive, alpha-beta T cell differentiation [GO:0043374]; cellular response to interferon-beta [GO:0035458]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of regulatory T cell differentiation [GO:0045590]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; regulation of adaptive immune response [GO:0002819]; regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000564]; regulation of cell cycle [GO:0051726]; regulation of innate immune response [GO:0045088]; regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034124]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]; type II interferon-mediated signaling pathway [GO:0060333]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; apoptotic process [GO:0006915]; CD8-positive, alpha-beta T cell differentiation [GO:0043374]; cellular response to interferon-beta [GO:0035458]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of regulatory T cell differentiation [GO:0045590]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; regulation of adaptive immune response [GO:0002819]; regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000564]; regulation of cell cycle [GO:0051726]; regulation of innate immune response [GO:0045088]; regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034124]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]; type II interferon-mediated signaling pathway [GO:0060333]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P15314}. Cytoplasm {ECO:0000250|UniProtKB:P15314}. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1. {ECO:0000250|UniProtKB:P15314}.
P10915	reviewed	HPLN1_HUMAN	Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Cartilage-link protein) (Proteoglycan link protein)	HAPLN1 CRTL1	Homo sapiens (Human)	354	FUNCTION: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.		cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202]	hyaluronic acid binding [GO:0005540]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202]; hyaluronic acid binding [GO:0005540]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
P10916	reviewed	MLRV_HUMAN	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)	MYL2 MLC2	Homo sapiens (Human)	166	FUNCTION: Contractile protein that plays a role in heart development and function (PubMed:23365102, PubMed:32453731). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). {ECO:0000250|UniProtKB:P08733, ECO:0000269|PubMed:23365102, ECO:0000269|PubMed:32453731}.	MISCELLANEOUS: This chain binds calcium.	cardiac muscle contraction [GO:0060048]; cardiac myofibril assembly [GO:0055003]; heart contraction [GO:0060047]; heart development [GO:0007507]; muscle cell fate specification [GO:0042694]; negative regulation of cell growth [GO:0030308]; positive regulation of the force of heart contraction [GO:0098735]; regulation of striated muscle contraction [GO:0006942]; regulation of the force of heart contraction [GO:0002026]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	A band [GO:0031672]; cardiac myofibril [GO:0097512]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; myofibril [GO:0030016]; myosin complex [GO:0016459]; sarcomere [GO:0030017]	actin monomer binding [GO:0003785]; calcium ion binding [GO:0005509]; myosin heavy chain binding [GO:0032036]; structural constituent of muscle [GO:0008307]	A band [GO:0031672]; cardiac myofibril [GO:0097512]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; myofibril [GO:0030016]; myosin complex [GO:0016459]; sarcomere [GO:0030017]; actin monomer binding [GO:0003785]; calcium ion binding [GO:0005509]; myosin heavy chain binding [GO:0032036]; structural constituent of muscle [GO:0008307]; cardiac muscle contraction [GO:0060048]; cardiac myofibril assembly [GO:0055003]; heart contraction [GO:0060047]; heart development [GO:0007507]; muscle cell fate specification [GO:0042694]; negative regulation of cell growth [GO:0030308]; positive regulation of the force of heart contraction [GO:0098735]; regulation of striated muscle contraction [GO:0006942]; regulation of the force of heart contraction [GO:0002026]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:P08733}.
P10966	reviewed	CD8B_HUMAN	T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b)	CD8B CD8B1	Homo sapiens (Human)	210	FUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells. {ECO:0000250|UniProtKB:P10300, ECO:0000269|PubMed:10925291, ECO:0000269|PubMed:11714755, ECO:0000269|PubMed:17145893}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; T cell receptor complex [GO:0042101]	coreceptor activity [GO:0015026]; MHC class I protein binding [GO:0042288]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; T cell receptor complex [GO:0042101]; coreceptor activity [GO:0015026]; MHC class I protein binding [GO:0042288]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:11714755, ECO:0000269|PubMed:3145196}; Single-pass type I membrane protein {ECO:0000305}. Note=Requires the partner CD8A for efficient cell surface expression (PubMed:3145196). The heterodimer CD8A/CD8B localizes to lipid rafts due to CD8B cytoplasmic tail palmitoylation. {ECO:0000269|PubMed:10925291, ECO:0000269|PubMed:11714755, ECO:0000269|PubMed:3145196}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted {ECO:0000305}.
P10997	reviewed	IAPP_HUMAN	Islet amyloid polypeptide (Amylin) (Diabetes-associated peptide) (DAP) (Insulinoma amyloid peptide)	IAPP	Homo sapiens (Human)	89	FUNCTION: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.	MISCELLANEOUS: IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor signaling pathway [GO:0097647]; apoptotic process [GO:0006915]; bone resorption [GO:0045453]; cell-cell signaling [GO:0007267]; eating behavior [GO:0042755]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of bone resorption [GO:0045779]; negative regulation of mitochondrion organization [GO:0010823]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein-containing complex assembly [GO:0031333]; osteoclast differentiation [GO:0030316]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase A signaling [GO:0010739]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	amyloid-beta binding [GO:0001540]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; amyloid-beta binding [GO:0001540]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; signaling receptor binding [GO:0005102]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor signaling pathway [GO:0097647]; apoptotic process [GO:0006915]; bone resorption [GO:0045453]; cell-cell signaling [GO:0007267]; eating behavior [GO:0042755]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of bone resorption [GO:0045779]; negative regulation of mitochondrion organization [GO:0010823]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein-containing complex assembly [GO:0031333]; osteoclast differentiation [GO:0030316]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase A signaling [GO:0010739]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17374526}.
P11021	reviewed	BIP_HUMAN	Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)	HSPA5 GRP78	Homo sapiens (Human)	654	FUNCTION: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:33432092, PubMed:15098107, PubMed:28053106). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:24355926, PubMed:20484814, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}.		cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-4 [GO:0071353]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum structural organization [GO:0021589]; chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell migration [GO:0030335]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; post-translational protein targeting to membrane, translocation [GO:0031204]; protein folding in endoplasmic reticulum [GO:0034975]; protein refolding [GO:0042026]; regulation of ATF6-mediated unfolded protein response [GO:1903891]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; regulation of PERK-mediated unfolded protein response [GO:1903897]; regulation of protein folding in endoplasmic reticulum [GO:0060904]; substantia nigra development [GO:0021762]; ubiquitin-dependent ERAD pathway [GO:0030433]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; misfolded protein binding [GO:0051787]; protein domain specific binding [GO:0019904]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; ribosome binding [GO:0043022]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; misfolded protein binding [GO:0051787]; protein domain specific binding [GO:0019904]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; ribosome binding [GO:0043022]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-4 [GO:0071353]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum structural organization [GO:0021589]; chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell migration [GO:0030335]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; post-translational protein targeting to membrane, translocation [GO:0031204]; protein folding in endoplasmic reticulum [GO:0034975]; protein refolding [GO:0042026]; regulation of ATF6-mediated unfolded protein response [GO:1903891]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; regulation of PERK-mediated unfolded protein response [GO:1903897]; regulation of protein folding in endoplasmic reticulum [GO:0060904]; substantia nigra development [GO:0021762]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:21080038, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:29497057}. Melanosome {ECO:0000269|PubMed:12643545}. Cytoplasm {ECO:0000250|UniProtKB:P20029}. Cell surface {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:27159390, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). Localizes to the cell surface of epithelial cells in response to high levels of free iron (PubMed:20484814, PubMed:24355926, PubMed:27159390). {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:27159390}.
P11047	reviewed	LAMC1_HUMAN	Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma)	LAMC1 LAMB2	Homo sapiens (Human)	1609	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.		cell adhesion [GO:0007155]; cell migration [GO:0016477]; endoderm development [GO:0007492]; extracellular matrix disassembly [GO:0022617]; hemidesmosome assembly [GO:0031581]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of cell adhesion [GO:0045785]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; protein-containing complex assembly [GO:0065003]; regulation of basement membrane organization [GO:0110011]; substrate adhesion-dependent cell spreading [GO:0034446]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-1 complex [GO:0005606]; laminin-10 complex [GO:0043259]; laminin-11 complex [GO:0043260]; protein complex involved in cell-matrix adhesion [GO:0098637]	extracellular matrix structural constituent [GO:0005201]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-1 complex [GO:0005606]; laminin-10 complex [GO:0043259]; laminin-11 complex [GO:0043260]; protein complex involved in cell-matrix adhesion [GO:0098637]; extracellular matrix structural constituent [GO:0005201]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; endoderm development [GO:0007492]; extracellular matrix disassembly [GO:0022617]; hemidesmosome assembly [GO:0031581]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of cell adhesion [GO:0045785]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; protein-containing complex assembly [GO:0065003]; regulation of basement membrane organization [GO:0110011]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
P11049	reviewed	CD37_HUMAN	Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26) (CD antigen CD37)	CD37 TSPAN26	Homo sapiens (Human)	281				extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P11055	reviewed	MYH3_HUMAN	Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE)	MYH3	Homo sapiens (Human)	1940	FUNCTION: Muscle contraction.		actin filament-based movement [GO:0030048]; ATP metabolic process [GO:0046034]; embryonic limb morphogenesis [GO:0030326]; face morphogenesis [GO:0060325]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; muscle organ development [GO:0007517]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; myosin phosphatase activity [GO:0017018]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; myosin phosphatase activity [GO:0017018]; actin filament-based movement [GO:0030048]; ATP metabolic process [GO:0046034]; embryonic limb morphogenesis [GO:0030326]; face morphogenesis [GO:0060325]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; muscle organ development [GO:0007517]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]	SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
P11086	reviewed	PNMT_HUMAN	Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase)	PNMT PENT	Homo sapiens (Human)	282	FUNCTION: Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117). Other substrates include phenylethanolamine and octopamine (PubMed:8812853, PubMed:16363801, PubMed:16277617). Also methylates normetanephrine (By similarity). {ECO:0000250|UniProtKB:P10937, ECO:0000269|PubMed:16277617, ECO:0000269|PubMed:16363801, ECO:0000269|PubMed:20496117, ECO:0000269|PubMed:8812853}.		catecholamine biosynthetic process [GO:0042423]; epinephrine biosynthetic process [GO:0042418]; methylation [GO:0032259]	cytosol [GO:0005829]	phenylethanolamine N-methyltransferase activity [GO:0004603]	cytosol [GO:0005829]; phenylethanolamine N-methyltransferase activity [GO:0004603]; catecholamine biosynthetic process [GO:0042423]; epinephrine biosynthetic process [GO:0042418]; methylation [GO:0032259]	
P11117	reviewed	PPAL_HUMAN	Lysosomal acid phosphatase (LAP) (EC 3.1.3.2)	ACP2	Homo sapiens (Human)	423			dephosphorylation [GO:0016311]; lysosome organization [GO:0007040]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]	acid phosphatase activity [GO:0003993]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; acid phosphatase activity [GO:0003993]; dephosphorylation [GO:0016311]; lysosome organization [GO:0007040]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:2684640, ECO:0000269|PubMed:3056714}; Single-pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000305|PubMed:2684640, ECO:0000305|PubMed:3056714}. Lysosome lumen. Note=The soluble form arises by proteolytic processing of the membrane-bound form. {ECO:0000269|PubMed:2684640, ECO:0000269|PubMed:3056714}.
P11137	reviewed	MTAP2_HUMAN	Microtubule-associated protein 2 (MAP-2)	MAP2	Homo sapiens (Human)	1827	FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.		central nervous system neuron development [GO:0021954]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of axon extension [GO:0030517]; negative regulation of microtubule binding [GO:1904527]; negative regulation of microtubule polymerization [GO:0031115]; neuron projection development [GO:0031175]; positive regulation of anterograde dense core granule transport [GO:1901953]; positive regulation of anterograde synaptic vesicle transport [GO:1903744]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle transport along microtubule [GO:1902513]; regulation of protein localization [GO:0032880]	apical distal dendrite [GO:0150014]; axon hillock [GO:0043203]; axon initial segment [GO:0043194]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; dendritic branch [GO:0044307]; dendritic filopodium [GO:1902737]; dendritic growth cone [GO:0044294]; dendritic shaft [GO:0043198]; distal dendrite [GO:0150002]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; primary dendrite [GO:0150001]; proximal dendrite [GO:1990635]; proximal neuron projection [GO:1990769]	calmodulin binding [GO:0005516]; dystroglycan binding [GO:0002162]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]	apical distal dendrite [GO:0150014]; axon hillock [GO:0043203]; axon initial segment [GO:0043194]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; dendritic branch [GO:0044307]; dendritic filopodium [GO:1902737]; dendritic growth cone [GO:0044294]; dendritic shaft [GO:0043198]; distal dendrite [GO:0150002]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; primary dendrite [GO:0150001]; proximal dendrite [GO:1990635]; proximal neuron projection [GO:1990769]; calmodulin binding [GO:0005516]; dystroglycan binding [GO:0002162]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; central nervous system neuron development [GO:0021954]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of axon extension [GO:0030517]; negative regulation of microtubule binding [GO:1904527]; negative regulation of microtubule polymerization [GO:0031115]; neuron projection development [GO:0031175]; positive regulation of anterograde dense core granule transport [GO:1901953]; positive regulation of anterograde synaptic vesicle transport [GO:1903744]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle transport along microtubule [GO:1902513]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:P20357}.
P11142	reviewed	HSP7C_HUMAN	Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)	HSPA8 HSC70 HSP73 HSPA10	Homo sapiens (Human)	646	FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:2799391, PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488, PubMed:12526792). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488, PubMed:12526792). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24318877, PubMed:27474739, PubMed:24121476, PubMed:26865365). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:2799391, PubMed:11559757, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:2799391, PubMed:11559757, PubMed:36586411). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). Interacts with VGF-derived peptide TLQP-21 (PubMed:28934328). {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:28934328, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}.		ATP metabolic process [GO:0046034]; cellular response to starvation [GO:0009267]; cellular response to steroid hormone stimulus [GO:0071383]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated autophagy [GO:0061684]; chaperone-mediated autophagy translocation complex disassembly [GO:1904764]; clathrin coat disassembly [GO:0072318]; late endosomal microautophagy [GO:0061738]; membrane organization [GO:0061024]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of supramolecular fiber organization [GO:1902904]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; protein folding [GO:0006457]; protein refolding [GO:0042026]; protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740]; regulation of cell cycle [GO:0051726]; regulation of postsynapse organization [GO:0099175]; regulation of protein complex stability [GO:0061635]; regulation of protein import [GO:1904589]; regulation of protein stability [GO:0031647]; regulation of protein-containing complex assembly [GO:0043254]; response to unfolded protein [GO:0006986]; slow axonal transport [GO:1990832]	autophagosome [GO:0005776]; blood microparticle [GO:0072562]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; glycinergic synapse [GO:0098690]; late endosome [GO:0005770]; lumenal side of lysosomal membrane [GO:0098575]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic specialization membrane [GO:0099634]; presynaptic cytosol [GO:0099523]; protein folding chaperone complex [GO:0101031]; Prp19 complex [GO:0000974]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]; spliceosomal complex [GO:0005681]; terminal bouton [GO:0043195]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ATP-dependent protein folding chaperone [GO:0140662]; C3HC4-type RING finger domain binding [GO:0055131]; cadherin binding [GO:0045296]; clathrin-uncoating ATPase activity [GO:1990833]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; MHC class II protein complex binding [GO:0023026]; phosphatidylserine binding [GO:0001786]; protein carrier chaperone [GO:0140597]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	autophagosome [GO:0005776]; blood microparticle [GO:0072562]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; glycinergic synapse [GO:0098690]; late endosome [GO:0005770]; lumenal side of lysosomal membrane [GO:0098575]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic specialization membrane [GO:0099634]; presynaptic cytosol [GO:0099523]; protein folding chaperone complex [GO:0101031]; Prp19 complex [GO:0000974]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]; spliceosomal complex [GO:0005681]; terminal bouton [GO:0043195]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ATP-dependent protein folding chaperone [GO:0140662]; C3HC4-type RING finger domain binding [GO:0055131]; cadherin binding [GO:0045296]; clathrin-uncoating ATPase activity [GO:1990833]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; MHC class II protein complex binding [GO:0023026]; phosphatidylserine binding [GO:0001786]; protein carrier chaperone [GO:0140597]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; ATP metabolic process [GO:0046034]; cellular response to starvation [GO:0009267]; cellular response to steroid hormone stimulus [GO:0071383]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated autophagy [GO:0061684]; chaperone-mediated autophagy translocation complex disassembly [GO:1904764]; clathrin coat disassembly [GO:0072318]; late endosomal microautophagy [GO:0061738]; membrane organization [GO:0061024]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of supramolecular fiber organization [GO:1902904]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; protein folding [GO:0006457]; protein refolding [GO:0042026]; protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740]; regulation of cell cycle [GO:0051726]; regulation of postsynapse organization [GO:0099175]; regulation of protein complex stability [GO:0061635]; regulation of protein import [GO:1904589]; regulation of protein stability [GO:0031647]; regulation of protein-containing complex assembly [GO:0043254]; response to unfolded protein [GO:0006986]; slow axonal transport [GO:1990832]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17289661}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus, nucleolus {ECO:0000269|PubMed:1586970}. Cell membrane. Lysosome membrane {ECO:0000269|PubMed:11559757}; Peripheral membrane protein {ECO:0000269|PubMed:11559757}; Cytoplasmic side {ECO:0000269|PubMed:11559757}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock (PubMed:1586970). {ECO:0000269|PubMed:1586970, ECO:0000269|PubMed:17289661}.
P11150	reviewed	LIPC_HUMAN	Hepatic triacylglycerol lipase (HL) (Hepatic lipase) (EC 3.1.1.3) (Lipase member C) (Lysophospholipase) (EC 3.1.1.5) (Phospholipase A1) (EC 3.1.1.32)	LIPC HTGL	Homo sapiens (Human)	499	FUNCTION: Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:7592706, PubMed:8798474, PubMed:12032167, PubMed:26193433). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (PubMed:26193433). {ECO:0000250|UniProtKB:P07867, ECO:0000269|PubMed:12032167, ECO:0000269|PubMed:26193433, ECO:0000269|PubMed:7592706, ECO:0000269|PubMed:8798474}.		cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; chylomicron remnant clearance [GO:0034382]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; intermediate-density lipoprotein particle remodeling [GO:0034373]; low-density lipoprotein particle remodeling [GO:0034374]; phosphatidylcholine catabolic process [GO:0034638]; reverse cholesterol transport [GO:0043691]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; very-low-density lipoprotein particle remodeling [GO:0034372]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]	1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; apolipoprotein binding [GO:0034185]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; low-density lipoprotein particle binding [GO:0030169]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]; triglyceride lipase activity [GO:0004806]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; apolipoprotein binding [GO:0034185]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; low-density lipoprotein particle binding [GO:0030169]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]; triglyceride lipase activity [GO:0004806]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; chylomicron remnant clearance [GO:0034382]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; intermediate-density lipoprotein particle remodeling [GO:0034373]; low-density lipoprotein particle remodeling [GO:0034374]; phosphatidylcholine catabolic process [GO:0034638]; reverse cholesterol transport [GO:0043691]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; very-low-density lipoprotein particle remodeling [GO:0034372]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2828141}.
P11161	reviewed	EGR2_HUMAN	E3 SUMO-protein ligase EGR2 (EC 2.3.2.-) (AT591) (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20)	EGR2 KROX20	Homo sapiens (Human)	476	FUNCTION: Sequence-specific DNA-binding transcription factor (PubMed:17717711). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity). {ECO:0000250|UniProtKB:P08152, ECO:0000269|PubMed:17717711}.; FUNCTION: E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity. {ECO:0000269|PubMed:21836637}.		aorta development [GO:0035904]; brain development [GO:0007420]; brain segmentation [GO:0035284]; cellular response to organic substance [GO:0071310]; facial nerve structural organization [GO:0021612]; fat cell differentiation [GO:0045444]; gene expression [GO:0010467]; learning or memory [GO:0007611]; motor neuron axon guidance [GO:0008045]; myelination [GO:0042552]; peripheral nervous system development [GO:0007422]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myelination [GO:0031643]; positive regulation of Schwann cell differentiation [GO:0014040]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein export from nucleus [GO:0006611]; protein sumoylation [GO:0016925]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of ossification [GO:0030278]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; rhombomere 3 formation [GO:0021660]; rhombomere 3 structural organization [GO:0021659]; rhombomere 5 formation [GO:0021666]; rhombomere 5 structural organization [GO:0021665]; rhythmic behavior [GO:0007622]; Schwann cell differentiation [GO:0014037]; skeletal muscle cell differentiation [GO:0035914]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; SUMO ligase activity [GO:0061665]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; SUMO ligase activity [GO:0061665]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; aorta development [GO:0035904]; brain development [GO:0007420]; brain segmentation [GO:0035284]; cellular response to organic substance [GO:0071310]; facial nerve structural organization [GO:0021612]; fat cell differentiation [GO:0045444]; gene expression [GO:0010467]; learning or memory [GO:0007611]; motor neuron axon guidance [GO:0008045]; myelination [GO:0042552]; peripheral nervous system development [GO:0007422]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myelination [GO:0031643]; positive regulation of Schwann cell differentiation [GO:0014040]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein export from nucleus [GO:0006611]; protein sumoylation [GO:0016925]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of ossification [GO:0030278]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; rhombomere 3 formation [GO:0021660]; rhombomere 3 structural organization [GO:0021659]; rhombomere 5 formation [GO:0021666]; rhombomere 5 structural organization [GO:0021665]; rhythmic behavior [GO:0007622]; Schwann cell differentiation [GO:0014037]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P08152}.
P11166	reviewed	GTR1_HUMAN	Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)	SLC2A1 GLUT1	Homo sapiens (Human)	492	FUNCTION: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:10227690). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P17809, ECO:0000250|UniProtKB:P46896, ECO:0000269|PubMed:10227690, ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:27078104}.		cellular hyperosmotic response [GO:0071474]; cellular response to glucose starvation [GO:0042149]; cellular response to mechanical stimulus [GO:0071260]; central nervous system development [GO:0007417]; cerebral cortex development [GO:0021987]; dehydroascorbic acid transport [GO:0070837]; female pregnancy [GO:0007565]; glucose import [GO:0046323]; glucose import across plasma membrane [GO:0098708]; glucose transmembrane transport [GO:1904659]; L-ascorbic acid metabolic process [GO:0019852]; long-chain fatty acid import across plasma membrane [GO:0015911]; photoreceptor cell maintenance [GO:0045494]; protein-containing complex assembly [GO:0065003]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to Thyroglobulin triiodothyronine [GO:1904016]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; caveola [GO:0005901]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; female germ cell nucleus [GO:0001674]; female pronucleus [GO:0001939]; glucose transporter complex [GO:1990350]; Golgi membrane [GO:0000139]; intercalated disc [GO:0014704]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; Z disc [GO:0030018]	D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; glucose transmembrane transporter activity [GO:0005355]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; long-chain fatty acid transporter activity [GO:0005324]; protein self-association [GO:0043621]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; caveola [GO:0005901]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; female germ cell nucleus [GO:0001674]; female pronucleus [GO:0001939]; glucose transporter complex [GO:1990350]; Golgi membrane [GO:0000139]; intercalated disc [GO:0014704]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; Z disc [GO:0030018]; D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; glucose transmembrane transporter activity [GO:0005355]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; long-chain fatty acid transporter activity [GO:0005324]; protein self-association [GO:0043621]; xenobiotic transmembrane transporter activity [GO:0042910]; cellular hyperosmotic response [GO:0071474]; cellular response to glucose starvation [GO:0042149]; cellular response to mechanical stimulus [GO:0071260]; central nervous system development [GO:0007417]; cerebral cortex development [GO:0021987]; dehydroascorbic acid transport [GO:0070837]; female pregnancy [GO:0007565]; glucose import [GO:0046323]; glucose import across plasma membrane [GO:0098708]; glucose transmembrane transport [GO:1904659]; L-ascorbic acid metabolic process [GO:0019852]; long-chain fatty acid import across plasma membrane [GO:0015911]; photoreceptor cell maintenance [GO:0045494]; protein-containing complex assembly [GO:0065003]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to Thyroglobulin triiodothyronine [GO:1904016]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:24847886, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:30197081}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P17809}. Note=Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:25982116, PubMed:24847886). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:24847886, ECO:0000269|PubMed:25982116}.
P11168	reviewed	GTR2_HUMAN	Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2)	SLC2A2 GLUT2	Homo sapiens (Human)	524	FUNCTION: Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:8027028, PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). {ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:23396969, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:3399500, ECO:0000269|PubMed:8027028, ECO:0000269|PubMed:8457197}.		carbohydrate metabolic process [GO:0005975]; dehydroascorbic acid transport [GO:0070837]; fructose transmembrane transport [GO:0015755]; galactose transmembrane transport [GO:0015757]; glucose import [GO:0046323]; glucose transmembrane transport [GO:1904659]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; fructose transmembrane transporter activity [GO:0005353]; galactose transmembrane transporter activity [GO:0005354]; glucose transmembrane transporter activity [GO:0005355]; hexose transmembrane transporter activity [GO:0015149]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; fructose transmembrane transporter activity [GO:0005353]; galactose transmembrane transporter activity [GO:0005354]; glucose transmembrane transporter activity [GO:0005355]; hexose transmembrane transporter activity [GO:0015149]; carbohydrate metabolic process [GO:0005975]; dehydroascorbic acid transport [GO:0070837]; fructose transmembrane transport [GO:0015755]; galactose transmembrane transport [GO:0015757]; glucose import [GO:0046323]; glucose transmembrane transport [GO:1904659]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28083649}; Multi-pass membrane protein {ECO:0000255}.
P11169	reviewed	GTR3_HUMAN	Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3)	SLC2A3 GLUT3	Homo sapiens (Human)	496	FUNCTION: Facilitative glucose transporter (PubMed:9477959, PubMed:26176916). Can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P32037, ECO:0000269|PubMed:26176916, ECO:0000269|PubMed:8457197, ECO:0000269|PubMed:9477959}.		carbohydrate metabolic process [GO:0005975]; dehydroascorbic acid transport [GO:0070837]; galactose transmembrane transport [GO:0015757]; glucose import [GO:0046323]; glucose import across plasma membrane [GO:0098708]; glucose transmembrane transport [GO:1904659]; L-ascorbic acid metabolic process [GO:0019852]; transport across blood-brain barrier [GO:0150104]	aggresome [GO:0016235]; cell projection [GO:0042995]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; galactose transmembrane transporter activity [GO:0005354]; glucose binding [GO:0005536]; glucose transmembrane transporter activity [GO:0005355]	aggresome [GO:0016235]; cell projection [GO:0042995]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; galactose transmembrane transporter activity [GO:0005354]; glucose binding [GO:0005536]; glucose transmembrane transporter activity [GO:0005355]; carbohydrate metabolic process [GO:0005975]; dehydroascorbic acid transport [GO:0070837]; galactose transmembrane transport [GO:0015757]; glucose import [GO:0046323]; glucose import across plasma membrane [GO:0098708]; glucose transmembrane transport [GO:1904659]; L-ascorbic acid metabolic process [GO:0019852]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9477959, ECO:0000305|PubMed:26176916}; Multi-pass membrane protein {ECO:0000269|PubMed:26176916}. Perikaryon {ECO:0000250|UniProtKB:Q07647}. Cell projection {ECO:0000250|UniProtKB:Q07647}. Note=Localized to densely spaced patches along neuronal processes. {ECO:0000250|UniProtKB:Q07647}.
P11171	reviewed	EPB41_HUMAN	Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1)	EPB41 E41P	Homo sapiens (Human)	864	FUNCTION: Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.		actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell cycle [GO:0007049]; cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to cell cortex [GO:1904778]; protein-containing complex assembly [GO:0065003]; regulation of calcium ion transport [GO:0051924]; regulation of intestinal absorption [GO:1904478]	basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cortical cytoskeleton [GO:0030863]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spectrin-associated cytoskeleton [GO:0014731]	1-phosphatidylinositol binding [GO:0005545]; actin binding [GO:0003779]; calmodulin binding [GO:0005516]; phosphoprotein binding [GO:0051219]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]	basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cortical cytoskeleton [GO:0030863]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spectrin-associated cytoskeleton [GO:0014731]; 1-phosphatidylinositol binding [GO:0005545]; actin binding [GO:0003779]; calmodulin binding [GO:0005516]; phosphoprotein binding [GO:0051219]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell cycle [GO:0007049]; cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to cell cortex [GO:1904778]; protein-containing complex assembly [GO:0065003]; regulation of calcium ion transport [GO:0051924]; regulation of intestinal absorption [GO:1904478]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12427749}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12427749, ECO:0000269|PubMed:23870127}. Nucleus {ECO:0000269|PubMed:12427749}.
P11172	reviewed	UMPS_HUMAN	Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)]	UMPS OK/SW-cl.21	Homo sapiens (Human)	480	FUNCTION: Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP). {ECO:0000269|PubMed:18184586, ECO:0000269|PubMed:9042911}.		'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; cellular response to xenobiotic stimulus [GO:0071466]; female pregnancy [GO:0007565]; lactation [GO:0007595]; pyrimidine nucleobase biosynthetic process [GO:0019856]; UDP biosynthetic process [GO:0006225]; UMP biosynthetic process [GO:0006222]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; orotate phosphoribosyltransferase activity [GO:0004588]; orotidine-5'-phosphate decarboxylase activity [GO:0004590]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; orotate phosphoribosyltransferase activity [GO:0004588]; orotidine-5'-phosphate decarboxylase activity [GO:0004590]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; cellular response to xenobiotic stimulus [GO:0071466]; female pregnancy [GO:0007565]; lactation [GO:0007595]; pyrimidine nucleobase biosynthetic process [GO:0019856]; UDP biosynthetic process [GO:0006225]; UMP biosynthetic process [GO:0006222]	
P11177	reviewed	ODPB_HUMAN	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)	PDHB PHE1B	Homo sapiens (Human)	359	FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:17474719, ECO:0000269|PubMed:19081061}.		acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099]	mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pyruvate dehydrogenase complex [GO:0045254]	pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]	mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pyruvate dehydrogenase complex [GO:0045254]; pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]; acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P11182	reviewed	ODB2_HUMAN	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)	DBT BCATE2	Homo sapiens (Human)	482	FUNCTION: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component.		branched-chain amino acid catabolic process [GO:0009083]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitochondrial alpha-ketoglutarate dehydrogenase complex [GO:0005947]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	acetyltransferase activity [GO:0016407]; dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity [GO:0043754]; lipoic acid binding [GO:0031405]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitochondrial alpha-ketoglutarate dehydrogenase complex [GO:0005947]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; acetyltransferase activity [GO:0016407]; dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity [GO:0043754]; lipoic acid binding [GO:0031405]; ubiquitin protein ligase binding [GO:0031625]; branched-chain amino acid catabolic process [GO:0009083]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P11215	reviewed	ITAM_HUMAN	Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)	ITGAM CD11B CR3A	Homo sapiens (Human)	1152	FUNCTION: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). {ECO:0000250|UniProtKB:P05555, ECO:0000269|PubMed:20008295, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:28807980, ECO:0000269|PubMed:9558116, ECO:0000305}.		amyloid-beta clearance [GO:0097242]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell surface receptor signaling pathway involved in cell-cell signaling [GO:1905114]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell-matrix adhesion [GO:0007160]; complement-mediated synapse pruning [GO:0150062]; ectodermal cell differentiation [GO:0010668]; forebrain development [GO:0030900]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; microglial cell activation [GO:0001774]; negative regulation of dopamine metabolic process [GO:0045963]; phagocytosis, engulfment [GO:0006911]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of prostaglandin-E synthase activity [GO:2000363]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of superoxide anion generation [GO:0032930]; receptor-mediated endocytosis [GO:0006898]; vertebrate eye-specific patterning [GO:0150064]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; integrin alphaM-beta2 complex [GO:0034688]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; complement component C3b binding [GO:0001851]; heat shock protein binding [GO:0031072]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; integrin alphaM-beta2 complex [GO:0034688]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; complement component C3b binding [GO:0001851]; heat shock protein binding [GO:0031072]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; amyloid-beta clearance [GO:0097242]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell surface receptor signaling pathway involved in cell-cell signaling [GO:1905114]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell-matrix adhesion [GO:0007160]; complement-mediated synapse pruning [GO:0150062]; ectodermal cell differentiation [GO:0010668]; forebrain development [GO:0030900]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; microglial cell activation [GO:0001774]; negative regulation of dopamine metabolic process [GO:0045963]; phagocytosis, engulfment [GO:0006911]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of prostaglandin-E synthase activity [GO:2000363]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of superoxide anion generation [GO:0032930]; receptor-mediated endocytosis [GO:0006898]; vertebrate eye-specific patterning [GO:0150064]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21193407}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:21193407}; Single-pass type I membrane protein {ECO:0000305}.
P11216	reviewed	PYGB_HUMAN	Glycogen phosphorylase, brain form (EC 2.4.1.1)	PYGB	Homo sapiens (Human)	843	FUNCTION: Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228). {ECO:0000269|PubMed:27402852, ECO:0000303|PubMed:3346228}.		glycogen catabolic process [GO:0005980]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]	glycogen phosphorylase activity [GO:0008184]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; glycogen phosphorylase activity [GO:0008184]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499]; glycogen catabolic process [GO:0005980]	
P11217	reviewed	PYGM_HUMAN	Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase)	PYGM	Homo sapiens (Human)	842	FUNCTION: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. {ECO:0000269|PubMed:8316268}.		glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	glycogen phosphorylase activity [GO:0008184]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; nucleotide binding [GO:0000166]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycogen phosphorylase activity [GO:0008184]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; nucleotide binding [GO:0000166]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]	
P11226	reviewed	MBL2_HUMAN	Mannose-binding protein C (MBP-C) (Collectin-1) (MBP1) (Mannan-binding protein) (Mannose-binding lectin)	MBL2 COLEC1 MBL	Homo sapiens (Human)	248	FUNCTION: Calcium-dependent lectin involved in innate immune defense (PubMed:35102342). Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342). {ECO:0000269|PubMed:14515269, ECO:0000269|PubMed:35102342}.		acute-phase response [GO:0006953]; antiviral innate immune response [GO:0140374]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, classical pathway [GO:0006958]; complement activation, lectin pathway [GO:0001867]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; killing by host of symbiont cells [GO:0051873]; negative regulation of viral process [GO:0048525]; opsonization [GO:0008228]; positive regulation of opsonization [GO:1903028]; positive regulation of phagocytosis [GO:0050766]; proteolysis [GO:0006508]; response to oxidative stress [GO:0006979]; surfactant homeostasis [GO:0043129]	cell surface [GO:0009986]; collagen trimer [GO:0005581]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; multivesicular body [GO:0005771]; serine-type endopeptidase complex [GO:1905370]	calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; mannose binding [GO:0005537]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; collagen trimer [GO:0005581]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; multivesicular body [GO:0005771]; serine-type endopeptidase complex [GO:1905370]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; mannose binding [GO:0005537]; signaling receptor binding [GO:0005102]; acute-phase response [GO:0006953]; antiviral innate immune response [GO:0140374]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, classical pathway [GO:0006958]; complement activation, lectin pathway [GO:0001867]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; killing by host of symbiont cells [GO:0051873]; negative regulation of viral process [GO:0048525]; opsonization [GO:0008228]; positive regulation of opsonization [GO:1903028]; positive regulation of phagocytosis [GO:0050766]; proteolysis [GO:0006508]; response to oxidative stress [GO:0006979]; surfactant homeostasis [GO:0043129]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7982896}.
P11229	reviewed	ACM1_HUMAN	Muscarinic acetylcholine receptor M1	CHRM1	Homo sapiens (Human)	460	FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.		adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of monoatomic ion transport [GO:0043270]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of glial cell proliferation [GO:0060251]; regulation of locomotion [GO:0040012]; regulation of postsynaptic membrane potential [GO:0060078]; saliva secretion [GO:0046541]; signal transduction [GO:0007165]	axon terminus [GO:0043679]; cholinergic synapse [GO:0098981]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]	G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; phosphatidylinositol phospholipase C activity [GO:0004435]	axon terminus [GO:0043679]; cholinergic synapse [GO:0098981]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; phosphatidylinositol phospholipase C activity [GO:0004435]; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of monoatomic ion transport [GO:0043270]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of glial cell proliferation [GO:0060251]; regulation of locomotion [GO:0040012]; regulation of postsynaptic membrane potential [GO:0060078]; saliva secretion [GO:0046541]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
P11230	reviewed	ACHB_HUMAN	Acetylcholine receptor subunit beta	CHRNB1 ACHRB CHRNB	Homo sapiens (Human)	501	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. {ECO:0000269|PubMed:27375219}.		behavioral response to nicotine [GO:0035095]; monoatomic cation transport [GO:0006812]; muscle cell development [GO:0055001]; muscle contraction [GO:0006936]; nervous system process [GO:0050877]; neuromuscular synaptic transmission [GO:0007274]; postsynaptic membrane organization [GO:0001941]; regulation of membrane potential [GO:0042391]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]	acetylcholine binding [GO:0042166]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]; ligand-gated monoatomic ion channel activity [GO:0015276]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; acetylcholine binding [GO:0042166]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]; ligand-gated monoatomic ion channel activity [GO:0015276]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; behavioral response to nicotine [GO:0035095]; monoatomic cation transport [GO:0006812]; muscle cell development [GO:0055001]; muscle contraction [GO:0006936]; nervous system process [GO:0050877]; neuromuscular synaptic transmission [GO:0007274]; postsynaptic membrane organization [GO:0001941]; regulation of membrane potential [GO:0042391]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
P11233	reviewed	RALA_HUMAN	Ras-related protein Ral-A (EC 3.6.5.2)	RALA RAL	Homo sapiens (Human)	206	FUNCTION: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors (PubMed:18756269, PubMed:19306925, PubMed:20005108, PubMed:21822277, PubMed:30500825). Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (PubMed:21822277). {ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:20005108, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:30500825}.		cell cycle [GO:0007049]; cell division [GO:0051301]; chemotaxis [GO:0006935]; establishment of protein localization to mitochondrion [GO:0072655]; exocytosis [GO:0006887]; membrane raft localization [GO:0051665]; neural tube closure [GO:0001843]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of mitochondrial fission [GO:0090141]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of exocytosis [GO:0017157]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; signal transduction [GO:0007165]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]	ATPase binding [GO:0051117]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin binding [GO:0017022]; ubiquitin protein ligase binding [GO:0031625]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]; ATPase binding [GO:0051117]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin binding [GO:0017022]; ubiquitin protein ligase binding [GO:0031625]; cell cycle [GO:0007049]; cell division [GO:0051301]; chemotaxis [GO:0006935]; establishment of protein localization to mitochondrion [GO:0072655]; exocytosis [GO:0006887]; membrane raft localization [GO:0051665]; neural tube closure [GO:0001843]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of mitochondrial fission [GO:0090141]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of exocytosis [GO:0017157]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925}; Lipid-anchor {ECO:0000269|PubMed:17875936}; Cytoplasmic side. Cleavage furrow {ECO:0000269|PubMed:18756269}. Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Mitochondrion {ECO:0000269|PubMed:21822277}. Note=Predominantly at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles (PubMed:19306925). May colocalize with CNTRL/centriolin at the midbody ring (PubMed:16213214). However, localization at the midbody at late cytokinesis was not confirmed (PubMed:18756269). Relocalizes to the mitochondrion during mitosis where it regulates mitochondrial fission (PubMed:21822277). {ECO:0000269|PubMed:16213214, ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:21822277}.
P11234	reviewed	RALB_HUMAN	Ras-related protein Ral-B (EC 3.6.5.2)	RALB	Homo sapiens (Human)	206	FUNCTION: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269). Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (PubMed:10393179). {ECO:0000250|UniProtKB:P36860, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to starvation [GO:0009267]; negative regulation of protein binding [GO:0032091]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of exocyst assembly [GO:0001928]; regulation of exocyst localization [GO:0060178]; signal transduction [GO:0007165]	extracellular exosome [GO:0070062]; midbody [GO:0030496]; plasma membrane [GO:0005886]	ATPase binding [GO:0051117]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ubiquitin protein ligase binding [GO:0031625]	extracellular exosome [GO:0070062]; midbody [GO:0030496]; plasma membrane [GO:0005886]; ATPase binding [GO:0051117]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to starvation [GO:0009267]; negative regulation of protein binding [GO:0032091]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of exocyst assembly [GO:0001928]; regulation of exocyst localization [GO:0060178]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17875936}; Lipid-anchor {ECO:0000269|PubMed:17875936}; Cytoplasmic side {ECO:0000269|PubMed:17875936}. Midbody {ECO:0000269|PubMed:18756269}. Note=During late cytokinesis, enriched at the midbody. {ECO:0000269|PubMed:18756269}.
P11245	reviewed	ARY2_HUMAN	Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (N-acetyltransferase type 2) (NAT-2) (Polymorphic arylamine N-acetyltransferase) (PNAT)	NAT2 AAC2	Homo sapiens (Human)	290	FUNCTION: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.		xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]	arylamine N-acetyltransferase activity [GO:0004060]	cytosol [GO:0005829]; arylamine N-acetyltransferase activity [GO:0004060]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm.
P11274	reviewed	BCR_HUMAN	Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)	BCR BCR1 D22S11	Homo sapiens (Human)	1271	FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}.		actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; brain development [GO:0007420]; cellular response to lipopolysaccharide [GO:0071222]; definitive hemopoiesis [GO:0060216]; focal adhesion assembly [GO:0048041]; homeostasis of number of cells [GO:0048872]; inner ear morphogenesis [GO:0042472]; intracellular protein transmembrane transport [GO:0065002]; keratinocyte differentiation [GO:0030216]; macrophage migration [GO:1905517]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of blood vessel remodeling [GO:0060313]; negative regulation of cellular extravasation [GO:0002692]; negative regulation of inflammatory response [GO:0050728]; negative regulation of macrophage migration [GO:1905522]; negative regulation of neutrophil degranulation [GO:0043314]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of respiratory burst [GO:0060268]; neuromuscular process controlling balance [GO:0050885]; neutrophil degranulation [GO:0043312]; phagocytosis [GO:0006909]; positive regulation of phagocytosis [GO:0050766]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of vascular permeability [GO:0043114]; renal system process [GO:0003014]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	axon [GO:0030424]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]	ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	axon [GO:0030424]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]; ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; brain development [GO:0007420]; cellular response to lipopolysaccharide [GO:0071222]; definitive hemopoiesis [GO:0060216]; focal adhesion assembly [GO:0048041]; homeostasis of number of cells [GO:0048872]; inner ear morphogenesis [GO:0042472]; intracellular protein transmembrane transport [GO:0065002]; keratinocyte differentiation [GO:0030216]; macrophage migration [GO:1905517]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of blood vessel remodeling [GO:0060313]; negative regulation of cellular extravasation [GO:0002692]; negative regulation of inflammatory response [GO:0050728]; negative regulation of macrophage migration [GO:1905522]; negative regulation of neutrophil degranulation [GO:0043314]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of respiratory burst [GO:0060268]; neuromuscular process controlling balance [GO:0050885]; neutrophil degranulation [GO:0043312]; phagocytosis [GO:0006909]; positive regulation of phagocytosis [GO:0050766]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of vascular permeability [GO:0043114]; renal system process [GO:0003014]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250|UniProtKB:Q6PAJ1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q6PAJ1}. Cell projection, axon {ECO:0000250|UniProtKB:Q6PAJ1}. Synapse {ECO:0000250|UniProtKB:F1LXF1}.
P11277	reviewed	SPTB1_HUMAN	Spectrin beta chain, erythrocytic (Beta-I spectrin)	SPTB SPTB1	Homo sapiens (Human)	2137	FUNCTION: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.	MISCELLANEOUS: This complex is anchored to the cytoplasmic face of the plasma membrane via another protein, ankyrin, which binds to beta-spectrin and mediates the binding of the whole complex to a transmembrane protein band 3. The interaction of erythrocyte spectrin with other proteins through specific binding domains lead to the formation of an extensive subplasmalemmal meshwork which is thought to be responsible for the maintenance of the biconcave shape of human erythrocytes, for the regulation of plasma membrane components and for the maintenance of the lipid asymmetry of the plasma membrane.; MISCELLANEOUS: [Isoform 3]: Due to exon skipping. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; modification of postsynaptic actin cytoskeleton [GO:0098885]	actin cytoskeleton [GO:0015629]; cell junction [GO:0030054]; cell projection [GO:0042995]; cell surface [GO:0009986]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; cell junction [GO:0030054]; cell projection [GO:0042995]; cell surface [GO:0009986]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; structural constituent of cytoskeleton [GO:0005200]; actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; modification of postsynaptic actin cytoskeleton [GO:0098885]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
P11279	reviewed	LAMP1_HUMAN	Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a)	LAMP1	Homo sapiens (Human)	417	FUNCTION: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Also plays an important role in NK-cells cytotoxicity (PubMed:2022921, PubMed:23632890). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (PubMed:7685349). {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23632890, ECO:0000269|PubMed:23847195, ECO:0000269|PubMed:37390818, ECO:0000269|PubMed:7685349}.; FUNCTION: (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085, PubMed:25972533, PubMed:27605678, PubMed:28448640). Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909). {ECO:0000269|PubMed:24970085, ECO:0000269|PubMed:25972533, ECO:0000269|PubMed:27605678, ECO:0000269|PubMed:28448640, ECO:0000269|PubMed:29295909}.; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. {ECO:0000269|PubMed:32295904}.		establishment of protein localization to organelle [GO:0072594]; Golgi to lysosome transport [GO:0090160]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; protein stabilization [GO:0050821]; regulation of organelle transport along microtubule [GO:1902513]	autolysosome [GO:0044754]; autophagosome membrane [GO:0000421]; azurophil granule membrane [GO:0035577]; cytolytic granule membrane [GO:0101004]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; phagolysosome membrane [GO:0061474]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; synaptic vesicle [GO:0008021]	enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; virus receptor activity [GO:0001618]	autolysosome [GO:0044754]; autophagosome membrane [GO:0000421]; azurophil granule membrane [GO:0035577]; cytolytic granule membrane [GO:0101004]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; phagolysosome membrane [GO:0061474]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; synaptic vesicle [GO:0008021]; enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; virus receptor activity [GO:0001618]; establishment of protein localization to organelle [GO:0072594]; Golgi to lysosome transport [GO:0090160]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; protein stabilization [GO:0050821]; regulation of organelle transport along microtubule [GO:1902513]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:16176980}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:16176980}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23847195}; Single-pass type I membrane protein {ECO:0000255}. Cytolytic granule membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:24088571}; Single-pass type I membrane protein {ECO:0000255}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). {ECO:0000250|UniProtKB:P05300, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}.
P11308	reviewed	ERG_HUMAN	Transcriptional regulator ERG (Transforming protein ERG)	ERG	Homo sapiens (Human)	479	FUNCTION: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.		positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:17289661}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
P11309	reviewed	PIM1_HUMAN	Serine/threonine-protein kinase pim-1 (EC 2.7.11.1)	PIM1	Homo sapiens (Human)	313	FUNCTION: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis (PubMed:15528381, PubMed:1825810, PubMed:31548394). Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3) (PubMed:18593906). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity (By similarity). The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis (By similarity). Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1 (By similarity). Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis (PubMed:19749799). Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C (PubMed:16356754). Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability (PubMed:12431783). Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels (PubMed:18593906). Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome-dependent degradation (PubMed:18593906). May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3 (PubMed:10664448). Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis (By similarity). Acts as a positive regulator of mTORC1 signaling by mediating phosphorylation and inhibition of DEPDC5 component of the GATOR1 complex (PubMed:31548394). Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells (PubMed:18056989). Promotes brown adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:P06803, ECO:0000269|PubMed:10664448, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:15528381, ECO:0000269|PubMed:16356754, ECO:0000269|PubMed:18056989, ECO:0000269|PubMed:1825810, ECO:0000269|PubMed:18593906, ECO:0000269|PubMed:19749799, ECO:0000269|PubMed:31548394}.	MISCELLANEOUS: [Isoform 2]: Initiates from CTG codon. {ECO:0000269|PubMed:16186805, ECO:0000269|PubMed:1825810}.	apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cellular detoxification [GO:1990748]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardioblast proliferation [GO:1905062]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TORC1 signaling [GO:1904263]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of transmembrane transporter activity [GO:0022898]; vitamin D receptor signaling pathway [GO:0070561]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; ribosomal small subunit binding [GO:0043024]; transcription factor binding [GO:0008134]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; ribosomal small subunit binding [GO:0043024]; transcription factor binding [GO:0008134]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cellular detoxification [GO:1990748]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardioblast proliferation [GO:1905062]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TORC1 signaling [GO:1904263]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of transmembrane transporter activity [GO:0022898]; vitamin D receptor signaling pathway [GO:0070561]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane.
P11310	reviewed	ACADM_HUMAN	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7) (Medium chain acyl-CoA dehydrogenase) (MCADH)	ACADM	Homo sapiens (Human)	421	FUNCTION: Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:1970566, PubMed:8823175, PubMed:21237683, PubMed:2251268). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:2251268). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:25416781, PubMed:15159392). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains (PubMed:1970566, PubMed:8823175, PubMed:21237683, PubMed:2251268). {ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:1970566, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:2251268, ECO:0000269|PubMed:25416781, ECO:0000269|PubMed:8823175}.		cardiac muscle cell differentiation [GO:0055007]; carnitine biosynthetic process [GO:0045329]; carnitine metabolic process, CoA-linked [GO:0019254]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; glycogen biosynthetic process [GO:0005978]; liver development [GO:0001889]; medium-chain fatty acid catabolic process [GO:0051793]; medium-chain fatty acid metabolic process [GO:0051791]; post-embryonic development [GO:0009791]; regulation of gluconeogenesis [GO:0006111]; response to cold [GO:0009409]; response to starvation [GO:0042594]	axon [GO:0030424]; cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; medium-chain-acyl-CoA dehydrogenase activity [GO:0070991]	axon [GO:0030424]; cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; medium-chain-acyl-CoA dehydrogenase activity [GO:0070991]; cardiac muscle cell differentiation [GO:0055007]; carnitine biosynthetic process [GO:0045329]; carnitine metabolic process, CoA-linked [GO:0019254]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; glycogen biosynthetic process [GO:0005978]; liver development [GO:0001889]; medium-chain fatty acid catabolic process [GO:0051793]; medium-chain fatty acid metabolic process [GO:0051791]; post-embryonic development [GO:0009791]; regulation of gluconeogenesis [GO:0006111]; response to cold [GO:0009409]; response to starvation [GO:0042594]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:16020546}.
P11362	reviewed	FGFR1_HUMAN	Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)	FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR	Homo sapiens (Human)	822	FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}.		cell migration [GO:0016477]; chordate embryonic development [GO:0043009]; epithelial to mesenchymal transition [GO:0001837]; fibroblast growth factor receptor signaling pathway [GO:0008543]; MAPK cascade [GO:0000165]; neuron migration [GO:0001764]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell differentiation [GO:0045595]; regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001239]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; receptor-receptor interaction [GO:0090722]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; receptor-receptor interaction [GO:0090722]; cell migration [GO:0016477]; chordate embryonic development [GO:0043009]; epithelial to mesenchymal transition [GO:0001837]; fibroblast growth factor receptor signaling pathway [GO:0008543]; MAPK cascade [GO:0000165]; neuron migration [GO:0001764]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell differentiation [GO:0045595]; regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001239]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
P11387	reviewed	TOP1_HUMAN	DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)	TOP1	Homo sapiens (Human)	765	FUNCTION: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the BMAL1 promoter. {ECO:0000250|UniProtKB:Q13472, ECO:0000269|PubMed:14594810, ECO:0000269|PubMed:16033260, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:22904072, ECO:0000269|PubMed:2833744}.	MISCELLANEOUS: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.	chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; programmed cell death [GO:0012501]; response to xenobiotic stimulus [GO:0009410]	chromosome [GO:0005694]; fibrillar center [GO:0001650]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perikaryon [GO:0043204]; protein-DNA complex [GO:0032993]	ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; double-stranded DNA binding [GO:0003690]; protein domain specific binding [GO:0019904]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]	chromosome [GO:0005694]; fibrillar center [GO:0001650]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perikaryon [GO:0043204]; protein-DNA complex [GO:0032993]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; double-stranded DNA binding [GO:0003690]; protein domain specific binding [GO:0019904]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]; chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; programmed cell death [GO:0012501]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12149243}. Nucleus, nucleoplasm {ECO:0000269|PubMed:12149243}. Note=Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumoylated forms found in both nucleoplasm and nucleoli.
P11388	reviewed	TOP2A_HUMAN	DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)	TOP2A TOP2	Homo sapiens (Human)	1531	FUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}.	MISCELLANEOUS: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.	apoptotic chromosome condensation [GO:0030263]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA ligation [GO:0006266]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; female meiotic nuclear division [GO:0007143]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of DNA duplex unwinding [GO:1905463]; positive regulation of apoptotic process [GO:0043065]; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045870]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; resolution of meiotic recombination intermediates [GO:0000712]; rhythmic process [GO:0048511]; sister chromatid segregation [GO:0000819]	chromosome, centromeric region [GO:0000775]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]	ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]	chromosome, centromeric region [GO:0000775]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; apoptotic chromosome condensation [GO:0030263]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA ligation [GO:0006266]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; female meiotic nuclear division [GO:0007143]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of DNA duplex unwinding [GO:1905463]; positive regulation of apoptotic process [GO:0043065]; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045870]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; resolution of meiotic recombination intermediates [GO:0000712]; rhythmic process [GO:0048511]; sister chromatid segregation [GO:0000819]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9155056}. Nucleus, nucleoplasm {ECO:0000269|PubMed:8299728}. Nucleus {ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:8299728, ECO:0000269|PubMed:9155056}. Nucleus, nucleolus {ECO:0000269|PubMed:9155056}.
P11413	reviewed	G6PD_HUMAN	Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49)	G6PD	Homo sapiens (Human)	515	FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:743300}.	MISCELLANEOUS: Binds two molecules of NADP. The first one is a cosubstrate (bound to the N-terminal domain), the second is bound to the C-terminal domain and functions as a structural element.	cellular response to oxidative stress [GO:0034599]; cholesterol biosynthetic process [GO:0006695]; erythrocyte maturation [GO:0043249]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glutathione metabolic process [GO:0006749]; lipid metabolic process [GO:0006629]; NADP metabolic process [GO:0006739]; NADPH regeneration [GO:0006740]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of protein glutathionylation [GO:0010734]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904879]; regulation of neuron apoptotic process [GO:0043523]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to iron(III) ion [GO:0010041]; response to organic cyclic compound [GO:0014070]; ribose phosphate biosynthetic process [GO:0046390]; substantia nigra development [GO:0021762]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	glucose binding [GO:0005536]; glucose-6-phosphate dehydrogenase activity [GO:0004345]; identical protein binding [GO:0042802]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; glucose binding [GO:0005536]; glucose-6-phosphate dehydrogenase activity [GO:0004345]; identical protein binding [GO:0042802]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; cellular response to oxidative stress [GO:0034599]; cholesterol biosynthetic process [GO:0006695]; erythrocyte maturation [GO:0043249]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glutathione metabolic process [GO:0006749]; lipid metabolic process [GO:0006629]; NADP metabolic process [GO:0006739]; NADPH regeneration [GO:0006740]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of protein glutathionylation [GO:0010734]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904879]; regulation of neuron apoptotic process [GO:0043523]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to iron(III) ion [GO:0010041]; response to organic cyclic compound [GO:0014070]; ribose phosphate biosynthetic process [GO:0046390]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:743300}. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:743300}.
P11441	reviewed	UBL4A_HUMAN	Ubiquitin-like protein 4A (Ubiquitin-like protein GDX)	UBL4A DXS254E GDX UBL4	Homo sapiens (Human)	157	FUNCTION: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892}.		post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein modification process [GO:0036211]; regulation of protein stability [GO:0031647]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent protein catabolic process [GO:0006511]	BAT3 complex [GO:0071818]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein-folding chaperone binding [GO:0051087]; ubiquitin-like protein transferase activity [GO:0019787]	BAT3 complex [GO:0071818]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-folding chaperone binding [GO:0051087]; ubiquitin-like protein transferase activity [GO:0019787]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein modification process [GO:0036211]; regulation of protein stability [GO:0031647]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303}. Nucleus {ECO:0000269|PubMed:21636303}.
P11464	reviewed	PSG1_HUMAN	Pregnancy-specific beta-1-glycoprotein 1 (PS-beta-G-1) (PSBG-1) (Pregnancy-specific glycoprotein 1) (CD66 antigen-like family member F) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (CD antigen CD66f)	PSG1 B1G1 PSBG1 PSGGA	Homo sapiens (Human)	419			female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	protein tyrosine kinase binding [GO:1990782]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein tyrosine kinase binding [GO:1990782]; female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P11473	reviewed	VDR_HUMAN	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)	VDR NR1I1	Homo sapiens (Human)	427	FUNCTION: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638). {ECO:0000250|UniProtKB:P13053, ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:12016314, ECO:0000269|PubMed:15728261, ECO:0000269|PubMed:16913708, ECO:0000269|PubMed:28698609, ECO:0000269|PubMed:32354638}.		apoptotic process involved in mammary gland involution [GO:0060057]; bile acid signaling pathway [GO:0038183]; calcium ion transport [GO:0006816]; cell differentiation [GO:0030154]; cell morphogenesis [GO:0000902]; decidualization [GO:0046697]; intestinal absorption [GO:0050892]; intracellular calcium ion homeostasis [GO:0006874]; lactation [GO:0007595]; mammary gland branching involved in pregnancy [GO:0060745]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphate ion transmembrane transport [GO:0035435]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of bone mineralization [GO:0030501]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vitamin D 24-hydroxylase activity [GO:0010980]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of calcidiol 1-monooxygenase activity [GO:0060558]; response to bile acid [GO:1903412]; skeletal system development [GO:0001501]; vitamin D receptor signaling pathway [GO:0070561]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575]	calcitriol binding [GO:1902098]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; lithocholic acid binding [GO:1902121]; lithocholic acid receptor activity [GO:0038186]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575]; calcitriol binding [GO:1902098]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; lithocholic acid binding [GO:1902121]; lithocholic acid receptor activity [GO:0038186]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; apoptotic process involved in mammary gland involution [GO:0060057]; bile acid signaling pathway [GO:0038183]; calcium ion transport [GO:0006816]; cell differentiation [GO:0030154]; cell morphogenesis [GO:0000902]; decidualization [GO:0046697]; intestinal absorption [GO:0050892]; intracellular calcium ion homeostasis [GO:0006874]; lactation [GO:0007595]; mammary gland branching involved in pregnancy [GO:0060745]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphate ion transmembrane transport [GO:0035435]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of bone mineralization [GO:0030501]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vitamin D 24-hydroxylase activity [GO:0010980]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of calcidiol 1-monooxygenase activity [GO:0060558]; response to bile acid [GO:1903412]; skeletal system development [GO:0001501]; vitamin D receptor signaling pathway [GO:0070561]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:28698609}. Cytoplasm {ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:28698609}. Note=Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331). Translocated into the nucleus via both ligand-dependent and ligand-independent pathways; ligand-independent nuclear translocation is mediated by IPO4 (PubMed:16207705). {ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:28698609}.
P11474	reviewed	ERR1_HUMAN	Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)	ESRRA ERR1 ESRL1 NR3B1	Homo sapiens (Human)	423	FUNCTION: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. {ECO:0000269|PubMed:12522104, ECO:0000269|PubMed:16150865, ECO:0000269|PubMed:17676930, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:23836911, ECO:0000269|PubMed:9271417}.		intracellular steroid hormone receptor signaling pathway [GO:0030518]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; protein domain specific binding [GO:0019904]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; protein domain specific binding [GO:0019904]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:21190936}. Cytoplasm {ECO:0000269|PubMed:21190936}. Note=Co-localizes to the cytoplasm only in presence of MAPK15. {ECO:0000269|PubMed:21190936}.
P11487	reviewed	FGF3_HUMAN	Fibroblast growth factor 3 (FGF-3) (Heparin-binding growth factor 3) (HBGF-3) (Proto-oncogene Int-2)	FGF3 INT2	Homo sapiens (Human)	239	FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. {ECO:0000269|PubMed:8663044}.		anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of cardiac muscle tissue development [GO:0055026]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of cardiac muscle tissue development [GO:0055026]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P11488	reviewed	GNAT1_HUMAN	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain)	GNAT1 GNATR	Homo sapiens (Human)	350	FUNCTION: Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). {ECO:0000250|UniProtKB:P04695, ECO:0000269|PubMed:22190596}.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; background adaptation [GO:0120302]; cell population proliferation [GO:0008283]; cellular response to electrical stimulus [GO:0071257]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; detection of light stimulus involved in visual perception [GO:0050908]; dopamine secretion [GO:0014046]; eye photoreceptor cell development [GO:0042462]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; neural tissue regeneration [GO:0097719]; phototransduction, visible light [GO:0007603]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; response to light stimulus [GO:0009416]; response to organic cyclic compound [GO:0014070]; retinal cone cell differentiation [GO:0042670]; retinal rod cell differentiation [GO:0060221]; rhodopsin mediated signaling pathway [GO:0016056]; sensory perception of umami taste [GO:0050917]; signal transduction [GO:0007165]; visual behavior [GO:0007632]; visual perception [GO:0007601]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; photoreceptor connecting cilium [GO:0032391]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]	acyl binding [GO:0000035]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; photoreceptor connecting cilium [GO:0032391]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; acyl binding [GO:0000035]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; background adaptation [GO:0120302]; cell population proliferation [GO:0008283]; cellular response to electrical stimulus [GO:0071257]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; detection of light stimulus involved in visual perception [GO:0050908]; dopamine secretion [GO:0014046]; eye photoreceptor cell development [GO:0042462]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; neural tissue regeneration [GO:0097719]; phototransduction, visible light [GO:0007603]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; response to light stimulus [GO:0009416]; response to organic cyclic compound [GO:0014070]; retinal cone cell differentiation [GO:0042670]; retinal rod cell differentiation [GO:0060221]; rhodopsin mediated signaling pathway [GO:0016056]; sensory perception of umami taste [GO:0050917]; signal transduction [GO:0007165]; visual behavior [GO:0007632]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P04695}. Membrane {ECO:0000250|UniProtKB:P04695}; Peripheral membrane protein {ECO:0000250|UniProtKB:P04695}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P20612}. Note=Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light. {ECO:0000250|UniProtKB:P20612}.
P11498	reviewed	PYC_HUMAN	Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)	PC	Homo sapiens (Human)	1178	FUNCTION: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. {ECO:0000269|PubMed:9585002}.		gluconeogenesis [GO:0006094]; lipid metabolic process [GO:0006629]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; negative regulation of gene expression [GO:0010629]; positive regulation by host of viral process [GO:0044794]; pyruvate metabolic process [GO:0006090]; viral release from host cell [GO:0019076]; viral RNA genome packaging [GO:0019074]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; biotin binding [GO:0009374]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pyruvate carboxylase activity [GO:0004736]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; biotin binding [GO:0009374]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pyruvate carboxylase activity [GO:0004736]; gluconeogenesis [GO:0006094]; lipid metabolic process [GO:0006629]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; negative regulation of gene expression [GO:0010629]; positive regulation by host of viral process [GO:0044794]; pyruvate metabolic process [GO:0006090]; viral release from host cell [GO:0019076]; viral RNA genome packaging [GO:0019074]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:9585002}.
P11509	reviewed	CP2A6_HUMAN	Cytochrome P450 2A6 (EC 1.14.14.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIA6) (Coumarin 7-hydroxylase) (Cytochrome P450 IIA3) (Cytochrome P450(I))	CYP2A6 CYP2A3	Homo sapiens (Human)	494	FUNCTION: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity. {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:16086027, ECO:0000269|PubMed:17125252, ECO:0000269|PubMed:18779312, ECO:0000269|PubMed:1889415, ECO:0000269|PubMed:1944238}.		coumarin catabolic process [GO:0046226]; coumarin metabolic process [GO:0009804]; epoxygenase P450 pathway [GO:0019373]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	arachidonic acid epoxygenase activity [GO:0008392]; coumarin 7-hydroxylase activity [GO:0008389]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; arachidonic acid epoxygenase activity [GO:0008392]; coumarin 7-hydroxylase activity [GO:0008389]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; coumarin catabolic process [GO:0046226]; coumarin metabolic process [GO:0009804]; epoxygenase P450 pathway [GO:0019373]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
P11511	reviewed	CP19A_HUMAN	Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase)	CYP19A1 ARO1 CYAR CYP19	Homo sapiens (Human)	503	FUNCTION: A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively (PubMed:27702664, PubMed:2848247). Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid (PubMed:20385561). Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen (PubMed:22773874). Also displays 2-hydroxylase activity toward estrone (PubMed:22773874). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:20385561, PubMed:22773874). {ECO:0000269|PubMed:20385561, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:27702664, ECO:0000269|PubMed:2848247}.		androgen catabolic process [GO:0006710]; estrogen biosynthetic process [GO:0006703]; female genitalia development [GO:0030540]; female gonad development [GO:0008585]; mammary gland development [GO:0030879]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of macrophage chemotaxis [GO:0010760]; positive regulation of estradiol secretion [GO:2000866]; prostate gland growth [GO:0060736]; response to estradiol [GO:0032355]; steroid biosynthetic process [GO:0006694]; sterol metabolic process [GO:0016125]; syncytium formation [GO:0006949]; testosterone biosynthetic process [GO:0061370]; uterus development [GO:0060065]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	aromatase activity [GO:0070330]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; steroid hydroxylase activity [GO:0008395]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; aromatase activity [GO:0070330]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; steroid hydroxylase activity [GO:0008395]; androgen catabolic process [GO:0006710]; estrogen biosynthetic process [GO:0006703]; female genitalia development [GO:0030540]; female gonad development [GO:0008585]; mammary gland development [GO:0030879]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of macrophage chemotaxis [GO:0010760]; positive regulation of estradiol secretion [GO:2000866]; prostate gland growth [GO:0060736]; response to estradiol [GO:0032355]; steroid biosynthetic process [GO:0006694]; sterol metabolic process [GO:0016125]; syncytium formation [GO:0006949]; testosterone biosynthetic process [GO:0061370]; uterus development [GO:0060065]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:2973313}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000269|PubMed:2973313}; Multi-pass membrane protein {ECO:0000305}.
P11532	reviewed	DMD_HUMAN	Dystrophin	DMD	Homo sapiens (Human)	3685	FUNCTION: Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}.	MISCELLANEOUS: The DMD gene is the largest known gene in humans. It is 2.4 million base-pairs in size, comprises 79 exons and takes over 16 hours to be transcribed and cotranscriptionally spliced.; MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing of isoform 4. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Produced by alternative splicing of isoform 6. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Produced by alternative splicing of isoform 6. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Produced by alternative splicing of isoform 6. {ECO:0000305}.; MISCELLANEOUS: [Isoform 10]: Produced by alternative splicing of isoform 6. {ECO:0000305}.; MISCELLANEOUS: [Isoform 11]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 12]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 13]: Produced by alternative splicing of isoform 12. {ECO:0000305}.; MISCELLANEOUS: [Isoform 14]: Produced by alternative splicing of isoform 12. {ECO:0000305}.; MISCELLANEOUS: [Isoform 15]: Produced by alternative splicing of isoform 12. {ECO:0000305}.; MISCELLANEOUS: [Isoform 16]: Produced by alternative splicing of isoform 12. {ECO:0000305}.; MISCELLANEOUS: [Isoform 17]: Produced by alternative splicing of isoform 12. {ECO:0000305}.	cardiac muscle cell action potential [GO:0086001]; cardiac muscle contraction [GO:0060048]; maintenance of blood-brain barrier [GO:0035633]; motile cilium assembly [GO:0044458]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]; muscle organ development [GO:0007517]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; neuron development [GO:0048666]; peptide biosynthetic process [GO:0043043]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cellular response to growth factor stimulus [GO:0090287]; regulation of heart rate [GO:0002027]; regulation of muscle system process [GO:0090257]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of skeletal muscle contraction [GO:0014819]; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809]; regulation of voltage-gated calcium channel activity [GO:1901385]; response to muscle stretch [GO:0035994]; skeletal muscle tissue development [GO:0007519]; synaptic signaling [GO:0099536]	cell surface [GO:0009986]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202]; syntrophin complex [GO:0016013]; Z disc [GO:0030018]	actin binding [GO:0003779]; dystroglycan binding [GO:0002162]; myosin binding [GO:0017022]; nitric-oxide synthase binding [GO:0050998]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; vinculin binding [GO:0017166]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202]; syntrophin complex [GO:0016013]; Z disc [GO:0030018]; actin binding [GO:0003779]; dystroglycan binding [GO:0002162]; myosin binding [GO:0017022]; nitric-oxide synthase binding [GO:0050998]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; vinculin binding [GO:0017166]; zinc ion binding [GO:0008270]; cardiac muscle cell action potential [GO:0086001]; cardiac muscle contraction [GO:0060048]; maintenance of blood-brain barrier [GO:0035633]; motile cilium assembly [GO:0044458]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]; muscle organ development [GO:0007517]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; neuron development [GO:0048666]; peptide biosynthetic process [GO:0043043]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cellular response to growth factor stimulus [GO:0090287]; regulation of heart rate [GO:0002027]; regulation of muscle system process [GO:0090257]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of skeletal muscle contraction [GO:0014819]; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809]; regulation of voltage-gated calcium channel activity [GO:1901385]; response to muscle stretch [GO:0035994]; skeletal muscle tissue development [GO:0007519]; synaptic signaling [GO:0099536]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P11531}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11531}; Cytoplasmic side {ECO:0000250|UniProtKB:P11531}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P11531}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P11531}. Note=In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs). In adult muscle, NMJ localization depends upon ANK2 presence, but not in newborn animals. {ECO:0000250|UniProtKB:P11531}.
P11586	reviewed	C1TC_HUMAN	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]	MTHFD1 MTHFC MTHFD	Homo sapiens (Human)	935	FUNCTION: Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:1881876, PubMed:10828945, PubMed:18767138). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:25633902, PubMed:18767138). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}.		10-formyltetrahydrofolate biosynthetic process [GO:0009257]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; heart development [GO:0007507]; histidine biosynthetic process [GO:0000105]; methionine biosynthetic process [GO:0009086]; methionine metabolic process [GO:0006555]; neural tube closure [GO:0001843]; neutrophil homeostasis [GO:0001780]; one-carbon metabolic process [GO:0006730]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleotide biosynthetic process [GO:0009152]; serine family amino acid biosynthetic process [GO:0009070]; serine family amino acid metabolic process [GO:0009069]; somite development [GO:0061053]; tetrahydrofolate interconversion [GO:0035999]; transsulfuration [GO:0019346]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity [GO:0004486]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity [GO:0004486]; 10-formyltetrahydrofolate biosynthetic process [GO:0009257]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; heart development [GO:0007507]; histidine biosynthetic process [GO:0000105]; methionine biosynthetic process [GO:0009086]; methionine metabolic process [GO:0006555]; neural tube closure [GO:0001843]; neutrophil homeostasis [GO:0001780]; one-carbon metabolic process [GO:0006730]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleotide biosynthetic process [GO:0009152]; serine family amino acid biosynthetic process [GO:0009070]; serine family amino acid metabolic process [GO:0009069]; somite development [GO:0061053]; tetrahydrofolate interconversion [GO:0035999]; transsulfuration [GO:0019346]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:3053686}.
P11597	reviewed	CETP_HUMAN	Cholesteryl ester transfer protein (Lipid transfer protein I)	CETP	Homo sapiens (Human)	493	FUNCTION: Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641, PubMed:3281933). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796). {ECO:0000269|PubMed:24293641, ECO:0000269|PubMed:3281933, ECO:0000303|PubMed:17237796, ECO:0000305|PubMed:3600759}.		cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; high-density lipoprotein particle remodeling [GO:0034375]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of phospholipid transport [GO:2001140]; regulation of cholesterol efflux [GO:0010874]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; triglyceride transport [GO:0034197]; very-low-density lipoprotein particle remodeling [GO:0034372]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; vesicle [GO:0031982]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; lipid binding [GO:0008289]; phosphatidylcholine binding [GO:0031210]; phospholipid transporter activity [GO:0005548]; triglyceride binding [GO:0017129]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; vesicle [GO:0031982]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; lipid binding [GO:0008289]; phosphatidylcholine binding [GO:0031210]; phospholipid transporter activity [GO:0005548]; triglyceride binding [GO:0017129]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; high-density lipoprotein particle remodeling [GO:0034375]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of phospholipid transport [GO:2001140]; regulation of cholesterol efflux [GO:0010874]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; triglyceride transport [GO:0034197]; very-low-density lipoprotein particle remodeling [GO:0034372]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24293641, ECO:0000269|PubMed:3281933}. Note=Secreted in plasma. {ECO:0000269|PubMed:3281933}.
P11678	reviewed	PERE_HUMAN	Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]	EPX EPER EPO EPP	Homo sapiens (Human)	715	FUNCTION: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. {ECO:0000269|PubMed:12540536, ECO:0000269|PubMed:18694936}.		defense response to bacterium [GO:0042742]; defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of macrophage cytokine production [GO:0010936]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule lumen [GO:0034774]	heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule lumen [GO:0034774]; heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]; defense response to bacterium [GO:0042742]; defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of macrophage cytokine production [GO:0010936]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.
P11684	reviewed	UTER_HUMAN	Uteroglobin (Club cell phospholipid-binding protein) (CCPBP) (Club cells 10 kDa secretory protein) (CC10) (Secretoglobin family 1A member 1) (Urinary protein 1) (UP-1) (UP1) (Urine protein 1)	SCGB1A1 CC10 CCSP UGB	Homo sapiens (Human)	91	FUNCTION: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.		embryo implantation [GO:0007566]; female pregnancy [GO:0007565]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; regulation of inflammatory response [GO:0050727]; regulation of mRNA stability [GO:0043488]; response to cytokine [GO:0034097]; response to fibroblast growth factor [GO:0071774]; response to glucocorticoid [GO:0051384]; response to lipopolysaccharide [GO:0032496]; response to ozone [GO:0010193]; response to silicon dioxide [GO:0034021]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; T cell proliferation [GO:0042098]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nuclear envelope [GO:0005635]; secretory granule [GO:0030141]	phospholipase A2 inhibitor activity [GO:0019834]; polychlorinated biphenyl binding [GO:0097160]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nuclear envelope [GO:0005635]; secretory granule [GO:0030141]; phospholipase A2 inhibitor activity [GO:0019834]; polychlorinated biphenyl binding [GO:0097160]; embryo implantation [GO:0007566]; female pregnancy [GO:0007565]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; regulation of inflammatory response [GO:0050727]; regulation of mRNA stability [GO:0043488]; response to cytokine [GO:0034097]; response to fibroblast growth factor [GO:0071774]; response to glucocorticoid [GO:0051384]; response to lipopolysaccharide [GO:0032496]; response to ozone [GO:0010193]; response to silicon dioxide [GO:0034021]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Secreted.
P11686	reviewed	PSPC_HUMAN	Pulmonary surfactant-associated protein C (SP-C) (Pulmonary surfactant-associated proteolipid SPL(Val)) (SP5)	SFTPC SFTP2	Homo sapiens (Human)	197	FUNCTION: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.	MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).	respiratory gaseous exchange by respiratory system [GO:0007585]	alveolar lamellar body [GO:0097208]; clathrin-coated endocytic vesicle [GO:0045334]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; multivesicular body lumen [GO:0097486]	identical protein binding [GO:0042802]	alveolar lamellar body [GO:0097208]; clathrin-coated endocytic vesicle [GO:0045334]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; multivesicular body lumen [GO:0097486]; identical protein binding [GO:0042802]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
P11712	reviewed	CP2C9_HUMAN	Cytochrome P450 2C9 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase)	CYP2C9 CYP2C10	Homo sapiens (Human)	490	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:7574697, PubMed:15766564, PubMed:19965576, PubMed:9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9866708, PubMed:9435160). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031). {ECO:0000269|PubMed:11950794, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15766564, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:25994031, ECO:0000269|PubMed:7574697, ECO:0000269|PubMed:9435160, ECO:0000269|PubMed:9866708}.		amide metabolic process [GO:0043603]; cholesterol metabolic process [GO:0008203]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; icosanoid biosynthetic process [GO:0046456]; long-chain fatty acid biosynthetic process [GO:0042759]; monocarboxylic acid metabolic process [GO:0032787]; monoterpenoid metabolic process [GO:0016098]; omega-hydroxylase P450 pathway [GO:0097267]; oxidative demethylation [GO:0070989]; steroid metabolic process [GO:0008202]; urea metabolic process [GO:0019627]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	(R)-limonene 6-monooxygenase activity [GO:0052741]; (S)-limonene 6-monooxygenase activity [GO:0018675]; (S)-limonene 7-monooxygenase activity [GO:0018676]; arachidonic acid 11,12-epoxygenase activity [GO:0008405]; arachidonic acid 14,15-epoxygenase activity [GO:0008404]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; caffeine oxidase activity [GO:0034875]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; (R)-limonene 6-monooxygenase activity [GO:0052741]; (S)-limonene 6-monooxygenase activity [GO:0018675]; (S)-limonene 7-monooxygenase activity [GO:0018676]; arachidonic acid 11,12-epoxygenase activity [GO:0008405]; arachidonic acid 14,15-epoxygenase activity [GO:0008404]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; caffeine oxidase activity [GO:0034875]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]; amide metabolic process [GO:0043603]; cholesterol metabolic process [GO:0008203]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; icosanoid biosynthetic process [GO:0046456]; long-chain fatty acid biosynthetic process [GO:0042759]; monocarboxylic acid metabolic process [GO:0032787]; monoterpenoid metabolic process [GO:0016098]; omega-hydroxylase P450 pathway [GO:0097267]; oxidative demethylation [GO:0070989]; steroid metabolic process [GO:0008202]; urea metabolic process [GO:0019627]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:21576599}; Peripheral membrane protein.
P11717	reviewed	MPRI_HUMAN	Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)	IGF2R MPRI	Homo sapiens (Human)	2491	FUNCTION: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}.		animal organ regeneration [GO:0031100]; G protein-coupled receptor signaling pathway [GO:0007186]; liver development [GO:0001889]; lysosomal transport [GO:0007041]; positive regulation by host of viral process [GO:0044794]; positive regulation of apoptotic process [GO:0043065]; post-embryonic development [GO:0009791]; receptor-mediated endocytosis [GO:0006898]; response to retinoic acid [GO:0032526]; response to tetrachloromethane [GO:1904772]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	cell surface [GO:0009986]; clathrin coat [GO:0030118]; clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; membrane [GO:0016020]; nuclear envelope lumen [GO:0005641]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133]	enzyme binding [GO:0019899]; G-protein alpha-subunit binding [GO:0001965]; identical protein binding [GO:0042802]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor II binding [GO:0031995]; insulin-like growth factor receptor activity [GO:0005010]; mannose binding [GO:0005537]; phosphoprotein binding [GO:0051219]; retinoic acid binding [GO:0001972]; retromer complex binding [GO:1905394]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; clathrin coat [GO:0030118]; clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; membrane [GO:0016020]; nuclear envelope lumen [GO:0005641]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133]; enzyme binding [GO:0019899]; G-protein alpha-subunit binding [GO:0001965]; identical protein binding [GO:0042802]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor II binding [GO:0031995]; insulin-like growth factor receptor activity [GO:0005010]; mannose binding [GO:0005537]; phosphoprotein binding [GO:0051219]; retinoic acid binding [GO:0001972]; retromer complex binding [GO:1905394]; signaling receptor activity [GO:0038023]; animal organ regeneration [GO:0031100]; G protein-coupled receptor signaling pathway [GO:0007186]; liver development [GO:0001889]; lysosomal transport [GO:0007041]; positive regulation by host of viral process [GO:0044794]; positive regulation of apoptotic process [GO:0043065]; post-embryonic development [GO:0009791]; receptor-mediated endocytosis [GO:0006898]; response to retinoic acid [GO:0032526]; response to tetrachloromethane [GO:1904772]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:18817523}; Single-pass type I membrane protein {ECO:0000269|PubMed:2957598}. Endosome membrane {ECO:0000269|PubMed:18817523}; Single-pass type I membrane protein {ECO:0000269|PubMed:2957598}. Note=Mainly localized in the Golgi at steady state and not detectable in lysosome (PubMed:18817523). Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18817523}.
P11766	reviewed	ADHX_HUMAN	Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284)	ADH5 ADHX FDH	Homo sapiens (Human)	374	FUNCTION: Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (PubMed:33355142). {ECO:0000269|PubMed:16081420, ECO:0000269|PubMed:33355142, ECO:0000269|PubMed:8460164}.	MISCELLANEOUS: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.	ethanol oxidation [GO:0006069]; fatty acid omega-oxidation [GO:0010430]; formaldehyde catabolic process [GO:0046294]; positive regulation of blood pressure [GO:0045777]; respiratory system process [GO:0003016]; response to lipopolysaccharide [GO:0032496]; response to nitrosative stress [GO:0051409]; response to redox state [GO:0051775]; retinoid metabolic process [GO:0001523]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; electron transfer activity [GO:0009055]; fatty acid binding [GO:0005504]; formaldehyde dehydrogenase activity [GO:0018467]; identical protein binding [GO:0042802]; S-(hydroxymethyl)glutathione dehydrogenase activity [GO:0051903]; S-(hydroxymethyl)glutathione dehydrogenase NAD activity [GO:0106322]; S-(hydroxymethyl)glutathione dehydrogenase NADP activity [GO:0106321]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; electron transfer activity [GO:0009055]; fatty acid binding [GO:0005504]; formaldehyde dehydrogenase activity [GO:0018467]; identical protein binding [GO:0042802]; S-(hydroxymethyl)glutathione dehydrogenase activity [GO:0051903]; S-(hydroxymethyl)glutathione dehydrogenase NAD activity [GO:0106322]; S-(hydroxymethyl)glutathione dehydrogenase NADP activity [GO:0106321]; zinc ion binding [GO:0008270]; ethanol oxidation [GO:0006069]; fatty acid omega-oxidation [GO:0010430]; formaldehyde catabolic process [GO:0046294]; positive regulation of blood pressure [GO:0045777]; respiratory system process [GO:0003016]; response to lipopolysaccharide [GO:0032496]; response to nitrosative stress [GO:0051409]; response to redox state [GO:0051775]; retinoid metabolic process [GO:0001523]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P11801	reviewed	KPSH1_HUMAN	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (Protein serine kinase H1) (PSK-H1)	PSKH1	Homo sapiens (Human)	424	FUNCTION: May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing. {ECO:0000269|PubMed:12466556}.		determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; phosphorylation [GO:0016310]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; microtubule organizing center [GO:0005815]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; microtubule organizing center [GO:0005815]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle. Endoplasmic reticulum membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Cytoplasm. Note=Localized in the brefeldin A-sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes.
P11802	reviewed	CDK4_HUMAN	Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)	CDK4	Homo sapiens (Human)	303	FUNCTION: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:9003781}.		cell division [GO:0051301]; cellular response to interleukin-4 [GO:0071353]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; regulation of transcription initiation by RNA polymerase II [GO:0060260]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to organic substance [GO:0010033]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]	bicellular tight junction [GO:0005923]; chromatin [GO:0000785]; cyclin D1-CDK4 complex [GO:0097128]; cyclin D2-CDK4 complex [GO:0097129]; cyclin D3-CDK4 complex [GO:0097130]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein serine kinase activity [GO:0106310]	bicellular tight junction [GO:0005923]; chromatin [GO:0000785]; cyclin D1-CDK4 complex [GO:0097128]; cyclin D2-CDK4 complex [GO:0097129]; cyclin D3-CDK4 complex [GO:0097130]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein serine kinase activity [GO:0106310]; cell division [GO:0051301]; cellular response to interleukin-4 [GO:0071353]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; regulation of transcription initiation by RNA polymerase II [GO:0060260]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to organic substance [GO:0010033]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18827403}. Nucleus {ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:20399237, ECO:0000269|PubMed:9106657}. Nucleus membrane {ECO:0000269|PubMed:18827403}. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus. {ECO:0000269|PubMed:18827403}.
P11831	reviewed	SRF_HUMAN	Serum response factor (SRF)	SRF	Homo sapiens (Human)	508	FUNCTION: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250|UniProtKB:Q9JM73}.		actin cytoskeleton organization [GO:0030036]; angiogenesis involved in wound healing [GO:0060055]; associative learning [GO:0008306]; axon extension [GO:0048675]; bicellular tight junction assembly [GO:0070830]; branching involved in blood vessel morphogenesis [GO:0001569]; bronchus cartilage development [GO:0060532]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac myofibril assembly [GO:0055003]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-matrix adhesion [GO:0007160]; cellular response to glucose stimulus [GO:0071333]; cellular senescence [GO:0090398]; dorsal aorta morphogenesis [GO:0035912]; epithelial cell-cell adhesion [GO:0090136]; epithelial structure maintenance [GO:0010669]; erythrocyte development [GO:0048821]; establishment of skin barrier [GO:0061436]; eyelid development in camera-type eye [GO:0061029]; face development [GO:0060324]; filopodium assembly [GO:0046847]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula formation [GO:0060347]; hematopoietic stem cell differentiation [GO:0060218]; hippocampus development [GO:0021766]; long-term memory [GO:0007616]; long-term synaptic depression [GO:0060292]; lung morphogenesis [GO:0060425]; lung smooth muscle development [GO:0061145]; megakaryocyte development [GO:0035855]; mesoderm formation [GO:0001707]; morphogenesis of an epithelial sheet [GO:0002011]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of miRNA transcription [GO:1902894]; neuron development [GO:0048666]; neuron migration [GO:0001764]; platelet activation [GO:0030168]; platelet formation [GO:0030220]; positive regulation of axon extension [GO:0045773]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by glucose [GO:0046016]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; positive thymic T cell selection [GO:0045059]; primitive streak formation [GO:0090009]; regulation of cell adhesion [GO:0030155]; regulation of smooth muscle cell differentiation [GO:0051150]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; sarcomere organization [GO:0045214]; skin morphogenesis [GO:0043589]; stress fiber assembly [GO:0043149]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea cartilage development [GO:0060534]; transcription by RNA polymerase II [GO:0006366]; trophectodermal cell differentiation [GO:0001829]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; serum response element binding [GO:0010736]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; serum response element binding [GO:0010736]; actin cytoskeleton organization [GO:0030036]; angiogenesis involved in wound healing [GO:0060055]; associative learning [GO:0008306]; axon extension [GO:0048675]; bicellular tight junction assembly [GO:0070830]; branching involved in blood vessel morphogenesis [GO:0001569]; bronchus cartilage development [GO:0060532]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac myofibril assembly [GO:0055003]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-matrix adhesion [GO:0007160]; cellular response to glucose stimulus [GO:0071333]; cellular senescence [GO:0090398]; dorsal aorta morphogenesis [GO:0035912]; epithelial cell-cell adhesion [GO:0090136]; epithelial structure maintenance [GO:0010669]; erythrocyte development [GO:0048821]; establishment of skin barrier [GO:0061436]; eyelid development in camera-type eye [GO:0061029]; face development [GO:0060324]; filopodium assembly [GO:0046847]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula formation [GO:0060347]; hematopoietic stem cell differentiation [GO:0060218]; hippocampus development [GO:0021766]; long-term memory [GO:0007616]; long-term synaptic depression [GO:0060292]; lung morphogenesis [GO:0060425]; lung smooth muscle development [GO:0061145]; megakaryocyte development [GO:0035855]; mesoderm formation [GO:0001707]; morphogenesis of an epithelial sheet [GO:0002011]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of miRNA transcription [GO:1902894]; neuron development [GO:0048666]; neuron migration [GO:0001764]; platelet activation [GO:0030168]; platelet formation [GO:0030220]; positive regulation of axon extension [GO:0045773]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by glucose [GO:0046016]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; positive thymic T cell selection [GO:0045059]; primitive streak formation [GO:0090009]; regulation of cell adhesion [GO:0030155]; regulation of smooth muscle cell differentiation [GO:0051150]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; sarcomere organization [GO:0045214]; skin morphogenesis [GO:0043589]; stress fiber assembly [GO:0043149]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea cartilage development [GO:0060534]; transcription by RNA polymerase II [GO:0006366]; trophectodermal cell differentiation [GO:0001829]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:19350017}.
P11836	reviewed	CD20_HUMAN	B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20)	MS4A1 CD20	Homo sapiens (Human)	297	FUNCTION: B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:7684739, PubMed:12920111, PubMed:18474602). {ECO:0000269|PubMed:12920111, ECO:0000269|PubMed:18474602, ECO:0000269|PubMed:3925015, ECO:0000269|PubMed:7684739}.		B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; calcium ion import into cytosol [GO:1902656]; cell surface receptor signaling pathway [GO:0007166]; humoral immune response [GO:0006959]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; protein tetramerization [GO:0051262]; response to bacterium [GO:0009617]; store-operated calcium entry [GO:0002115]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]	epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; immunoglobulin binding [GO:0019865]; MHC class II protein complex binding [GO:0023026]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; immunoglobulin binding [GO:0019865]; MHC class II protein complex binding [GO:0023026]; B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; calcium ion import into cytosol [GO:1902656]; cell surface receptor signaling pathway [GO:0007166]; humoral immune response [GO:0006959]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; protein tetramerization [GO:0051262]; response to bacterium [GO:0009617]; store-operated calcium entry [GO:0002115]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12920111, ECO:0000269|PubMed:22615937}; Multi-pass membrane protein {ECO:0000269|PubMed:22615937}. Cell membrane {ECO:0000269|PubMed:22615937}; Lipid-anchor {ECO:0000269|PubMed:22615937}. Note=Constitutively associated with membrane rafts. {ECO:0000269|PubMed:12920111}.
P11908	reviewed	PRPS2_HUMAN	Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II)	PRPS2	Homo sapiens (Human)	318	FUNCTION: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.		5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; nucleobase-containing compound metabolic process [GO:0006139]; pentose-phosphate shunt [GO:0006098]; phosphorylation [GO:0016310]; purine nucleotide biosynthetic process [GO:0006164]; ribonucleoside monophosphate biosynthetic process [GO:0009156]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribose phosphate diphosphokinase complex [GO:0002189]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribose phosphate diphosphokinase complex [GO:0002189]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; nucleobase-containing compound metabolic process [GO:0006139]; pentose-phosphate shunt [GO:0006098]; phosphorylation [GO:0016310]; purine nucleotide biosynthetic process [GO:0006164]; ribonucleoside monophosphate biosynthetic process [GO:0009156]	
P11912	reviewed	CD79A_HUMAN	B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)	CD79A IGA MB1	Homo sapiens (Human)	226	FUNCTION: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells. {ECO:0000269|PubMed:8617796, ECO:0000269|PubMed:9057631}.		adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]	B cell receptor complex [GO:0019815]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]	B cell receptor complex [GO:0019815]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.
P11926	reviewed	DCOR_HUMAN	Ornithine decarboxylase (ODC) (EC 4.1.1.17)	ODC1	Homo sapiens (Human)	461	FUNCTION: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. {ECO:0000269|PubMed:17900240}.		cell population proliferation [GO:0008283]; kidney development [GO:0001822]; polyamine metabolic process [GO:0006595]; positive regulation of cell population proliferation [GO:0008284]; putrescine biosynthetic process from ornithine [GO:0033387]; regulation of protein catabolic process [GO:0042176]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ornithine decarboxylase activity [GO:0004586]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ornithine decarboxylase activity [GO:0004586]; protein homodimerization activity [GO:0042803]; cell population proliferation [GO:0008283]; kidney development [GO:0001822]; polyamine metabolic process [GO:0006595]; positive regulation of cell population proliferation [GO:0008284]; putrescine biosynthetic process from ornithine [GO:0033387]; regulation of protein catabolic process [GO:0042176]; response to virus [GO:0009615]	
P11940	reviewed	PABP1_HUMAN	Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)	PABPC1 PAB1 PABP PABP1 PABPC2	Homo sapiens (Human)	636	FUNCTION: Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}.	MISCELLANEOUS: Many viruses shutoff host mRNA translational machinery by inhibiting cellular PABPC1 activity using different mechanisms. Picornaviruses, caliciviruses or lentiviruses encode proteases that cleave PABPC1 at several defined sites in the proline-rich linker region between RRMs and the C-terminal domain. Rotaviruses, gammherpesviruses and bunyamwera virus relocalize PABPC1 from the cytoplasm to the nucleus thus altering its function. Many of these viruses translate their mRNA in a PABPC1-independent manner and are unaffected by host PABPC1 inhibition.	CRD-mediated mRNA stabilization [GO:0070934]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of viral genome replication [GO:0045070]; regulatory ncRNA-mediated gene silencing [GO:0031047]	catalytic step 2 spliceosome [GO:0071013]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mCRD-mediated mRNA stability complex [GO:0106002]; membrane [GO:0016020]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]	catalytic step 2 spliceosome [GO:0071013]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mCRD-mediated mRNA stability complex [GO:0106002]; membrane [GO:0016020]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of viral genome replication [GO:0045070]; regulatory ncRNA-mediated gene silencing [GO:0031047]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:31649314, ECO:0000269|PubMed:7908267, ECO:0000269|PubMed:9582337}. Cytoplasm, Stress granule {ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:27573237}. Nucleus {ECO:0000269|PubMed:18799579, ECO:0000269|PubMed:9582337}. Cell projection, lamellipodium {ECO:0000269|PubMed:28733330}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Shuttles between the cytoplasm and the nucleus (PubMed:9582337). During stress and in the absence of DDX3X, localizes to the nucleus (PubMed:21883093). At the leading edge of migrating fibroblasts, colocalizes with DDX3X (PubMed:28733330). Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with ENDOV (PubMed:27573237). In case of HRSV infection, localizes in cytoplasmic inclusion bodies substructures called inclusion bodies associated granules (IBAGs) (PubMed:31649314). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:31649314, ECO:0000269|PubMed:9582337}.
P12004	reviewed	PCNA_HUMAN	Proliferating cell nuclear antigen (PCNA) (Cyclin)	PCNA	Homo sapiens (Human)	261	FUNCTION: Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (PubMed:35585232). Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (PubMed:24695737). {ECO:0000269|PubMed:18719106, ECO:0000269|PubMed:19443450, ECO:0000269|PubMed:24695737, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:35585232}.	MISCELLANEOUS: Antibodies against PCNA are present in sera from patients with systemic lupus erythematosus.	base-excision repair, gap-filling [GO:0006287]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to UV [GO:0034644]; cellular response to xenobiotic stimulus [GO:0071466]; epithelial cell differentiation [GO:0030855]; estrous cycle [GO:0044849]; heart development [GO:0007507]; leading strand elongation [GO:0006272]; liver regeneration [GO:0097421]; mismatch repair [GO:0006298]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of deoxyribonuclease activity [GO:0032077]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; replication fork processing [GO:0031297]; response to cadmium ion [GO:0046686]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to L-glutamate [GO:1902065]; translesion synthesis [GO:0019985]	centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear lamina [GO:0005652]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCNA complex [GO:0043626]; PCNA-p21 complex [GO:0070557]; replication fork [GO:0005657]; replisome [GO:0030894]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; dinucleotide insertion or deletion binding [GO:0032139]; DNA polymerase binding [GO:0070182]; DNA polymerase processivity factor activity [GO:0030337]; enzyme binding [GO:0019899]; histone acetyltransferase binding [GO:0035035]; identical protein binding [GO:0042802]; MutLalpha complex binding [GO:0032405]; nuclear estrogen receptor binding [GO:0030331]; protein-containing complex binding [GO:0044877]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]; receptor tyrosine kinase binding [GO:0030971]	centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear lamina [GO:0005652]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCNA complex [GO:0043626]; PCNA-p21 complex [GO:0070557]; replication fork [GO:0005657]; replisome [GO:0030894]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; dinucleotide insertion or deletion binding [GO:0032139]; DNA polymerase binding [GO:0070182]; DNA polymerase processivity factor activity [GO:0030337]; enzyme binding [GO:0019899]; histone acetyltransferase binding [GO:0035035]; identical protein binding [GO:0042802]; MutLalpha complex binding [GO:0032405]; nuclear estrogen receptor binding [GO:0030331]; protein-containing complex binding [GO:0044877]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]; receptor tyrosine kinase binding [GO:0030971]; base-excision repair, gap-filling [GO:0006287]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to UV [GO:0034644]; cellular response to xenobiotic stimulus [GO:0071466]; epithelial cell differentiation [GO:0030855]; estrous cycle [GO:0044849]; heart development [GO:0007507]; leading strand elongation [GO:0006272]; liver regeneration [GO:0097421]; mismatch repair [GO:0006298]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of deoxyribonuclease activity [GO:0032077]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; replication fork processing [GO:0031297]; response to cadmium ion [GO:0046686]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to L-glutamate [GO:1902065]; translesion synthesis [GO:0019985]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:24115439, ECO:0000269|PubMed:24939902}. Note=Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. {ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:24939902}.
P12018	reviewed	VPREB_HUMAN	Immunoglobulin iota chain (CD179 antigen-like family member A) (Protein VPreB1) (V(pre)B protein) (VpreB protein) (CD antigen CD179a)	VPREB1 VPREB	Homo sapiens (Human)	145	FUNCTION: Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.		immune response [GO:0006955]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]		endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:P13372}.
P12034	reviewed	FGF5_HUMAN	Fibroblast growth factor 5 (FGF-5) (Heparin-binding growth factor 5) (HBGF-5) (Smag-82)	FGF5	Homo sapiens (Human)	268	FUNCTION: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity). {ECO:0000250|UniProtKB:Q20FD0, ECO:0000269|PubMed:8663044}.	MISCELLANEOUS: [Isoform Short]: Seems to have an antagonistic effect compared to that of the isoform Long. {ECO:0000305}.	animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glial cell differentiation [GO:0010001]; nervous system development [GO:0007399]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]; signal transduction involved in regulation of gene expression [GO:0023019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glial cell differentiation [GO:0010001]; nervous system development [GO:0007399]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]; signal transduction involved in regulation of gene expression [GO:0023019]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P12035	reviewed	K2C3_HUMAN	Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3)	KRT3	Homo sapiens (Human)	628		MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	epithelial cell differentiation [GO:0030855]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; epithelial cell differentiation [GO:0030855]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
P12036	reviewed	NFH_HUMAN	Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein)	NEFH KIAA0845 NFH	Homo sapiens (Human)	1026	FUNCTION: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}.		axon development [GO:0061564]; axonogenesis [GO:0007409]; cell projection assembly [GO:0030031]; cellular response to leukemia inhibitory factor [GO:1990830]; intermediate filament bundle assembly [GO:0045110]; microtubule cytoskeleton organization [GO:0000226]; neurofilament bundle assembly [GO:0033693]; neurofilament cytoskeleton organization [GO:0060052]; peripheral nervous system neuron axonogenesis [GO:0048936]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of organelle transport along microtubule [GO:1902513]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; neurofibrillary tangle [GO:0097418]; neurofilament [GO:0005883]; postsynaptic density [GO:0014069]; postsynaptic intermediate filament cytoskeleton [GO:0099160]; Schaffer collateral - CA1 synapse [GO:0098685]	dynein complex binding [GO:0070840]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic intermediate filament cytoskeleton [GO:0099184]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; neurofibrillary tangle [GO:0097418]; neurofilament [GO:0005883]; postsynaptic density [GO:0014069]; postsynaptic intermediate filament cytoskeleton [GO:0099160]; Schaffer collateral - CA1 synapse [GO:0098685]; dynein complex binding [GO:0070840]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic intermediate filament cytoskeleton [GO:0099184]; axon development [GO:0061564]; axonogenesis [GO:0007409]; cell projection assembly [GO:0030031]; cellular response to leukemia inhibitory factor [GO:1990830]; intermediate filament bundle assembly [GO:0045110]; microtubule cytoskeleton organization [GO:0000226]; neurofilament bundle assembly [GO:0033693]; neurofilament cytoskeleton organization [GO:0060052]; peripheral nervous system neuron axonogenesis [GO:0048936]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of organelle transport along microtubule [GO:1902513]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:27040688}. Cell projection, axon {ECO:0000250|UniProtKB:P19246}.
P12074	reviewed	CX6A1_HUMAN	Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver) (Cytochrome c oxidase subunit VIA-liver) (COX VIa-L)	COX6A1 COX6AL	Homo sapiens (Human)	109	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P32799}.		cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]	enzyme regulator activity [GO:0030234]; oxidoreductase activity [GO:0016491]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; enzyme regulator activity [GO:0030234]; oxidoreductase activity [GO:0016491]; cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
P12081	reviewed	HARS1_HUMAN	Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)	HARS1 HARS HRS	Homo sapiens (Human)	509	FUNCTION: Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516). {ECO:0000269|PubMed:26072516, ECO:0000269|PubMed:29235198}.		histidyl-tRNA aminoacylation [GO:0006427]; mitochondrial translation [GO:0032543]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; histidine-tRNA ligase activity [GO:0004821]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; histidine-tRNA ligase activity [GO:0004821]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; histidyl-tRNA aminoacylation [GO:0006427]; mitochondrial translation [GO:0032543]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:F1Q5D5}.
P12104	reviewed	FABPI_HUMAN	Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP)	FABP2 FABPI	Homo sapiens (Human)	132	FUNCTION: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.		fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; intestinal lipid absorption [GO:0098856]	apical cortex [GO:0045179]; cytosol [GO:0005829]; microvillus [GO:0005902]; nucleus [GO:0005634]	fatty acid binding [GO:0005504]; long-chain fatty acid binding [GO:0036041]; long-chain fatty acid transporter activity [GO:0005324]	apical cortex [GO:0045179]; cytosol [GO:0005829]; microvillus [GO:0005902]; nucleus [GO:0005634]; fatty acid binding [GO:0005504]; long-chain fatty acid binding [GO:0036041]; long-chain fatty acid transporter activity [GO:0005324]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; intestinal lipid absorption [GO:0098856]	SUBCELLULAR LOCATION: Cytoplasm.
P12107	reviewed	COBA1_HUMAN	Collagen alpha-1(XI) chain	COL11A1 COLL6	Homo sapiens (Human)	1806	FUNCTION: May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.		cartilage condensation [GO:0001502]; chondrocyte development [GO:0002063]; collagen fibril organization [GO:0030199]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; embryonic skeletal system morphogenesis [GO:0048704]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; inner ear morphogenesis [GO:0042472]; ossification [GO:0001503]; proteoglycan metabolic process [GO:0006029]; sensory perception of sound [GO:0007605]; tendon development [GO:0035989]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visual perception [GO:0007601]	collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]	collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; cartilage condensation [GO:0001502]; chondrocyte development [GO:0002063]; collagen fibril organization [GO:0030199]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; embryonic skeletal system morphogenesis [GO:0048704]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; inner ear morphogenesis [GO:0042472]; ossification [GO:0001503]; proteoglycan metabolic process [GO:0006029]; sensory perception of sound [GO:0007605]; tendon development [GO:0035989]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
P12109	reviewed	CO6A1_HUMAN	Collagen alpha-1(VI) chain	COL6A1	Homo sapiens (Human)	1028	FUNCTION: Collagen VI acts as a cell-binding protein.		cell adhesion [GO:0007155]; cellular response to amino acid stimulus [GO:0071230]; endodermal cell differentiation [GO:0035987]; osteoblast differentiation [GO:0001649]	collagen type VI trimer [GO:0005589]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]	collagen binding [GO:0005518]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; platelet-derived growth factor binding [GO:0048407]	collagen type VI trimer [GO:0005589]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; collagen binding [GO:0005518]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; platelet-derived growth factor binding [GO:0048407]; cell adhesion [GO:0007155]; cellular response to amino acid stimulus [GO:0071230]; endodermal cell differentiation [GO:0035987]; osteoblast differentiation [GO:0001649]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
P12110	reviewed	CO6A2_HUMAN	Collagen alpha-2(VI) chain	COL6A2	Homo sapiens (Human)	1019	FUNCTION: Collagen VI acts as a cell-binding protein.		cell adhesion [GO:0007155]; response to glucose [GO:0009749]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]	collagen binding [GO:0005518]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; collagen binding [GO:0005518]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; cell adhesion [GO:0007155]; response to glucose [GO:0009749]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:8305732}. Membrane {ECO:0000269|PubMed:8305732}; Peripheral membrane protein {ECO:0000269|PubMed:8305732}. Note=Recruited on membranes by CSPG4.
P12111	reviewed	CO6A3_HUMAN	Collagen alpha-3(VI) chain	COL6A3	Homo sapiens (Human)	3177	FUNCTION: Collagen VI acts as a cell-binding protein.		cell adhesion [GO:0007155]; muscle organ development [GO:0007517]; response to glucose [GO:0009749]	collagen type VI trimer [GO:0005589]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; sarcolemma [GO:0042383]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; serine-type endopeptidase inhibitor activity [GO:0004867]	collagen type VI trimer [GO:0005589]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; sarcolemma [GO:0042383]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; serine-type endopeptidase inhibitor activity [GO:0004867]; cell adhesion [GO:0007155]; muscle organ development [GO:0007517]; response to glucose [GO:0009749]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
P12235	reviewed	ADT1_HUMAN	ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4)	SLC25A4 AAC1 ANT1	Homo sapiens (Human)	298	FUNCTION: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:21586654, PubMed:27693233). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31883789). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:21586654, ECO:0000269|PubMed:27693233, ECO:0000269|PubMed:31883789}.		adaptive thermogenesis [GO:1990845]; ADP transport [GO:0015866]; apoptotic mitochondrial changes [GO:0008637]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; mitochondrial genome maintenance [GO:0000002]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of necroptotic process [GO:0060546]; positive regulation of mitophagy [GO:1901526]; regulation of mitochondrial membrane permeability [GO:0046902]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	adenine transmembrane transporter activity [GO:0015207]; ATP:ADP antiporter activity [GO:0005471]; oxidative phosphorylation uncoupler activity [GO:0017077]; proton transmembrane transporter activity [GO:0015078]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; adenine transmembrane transporter activity [GO:0015207]; ATP:ADP antiporter activity [GO:0005471]; oxidative phosphorylation uncoupler activity [GO:0017077]; proton transmembrane transporter activity [GO:0015078]; adaptive thermogenesis [GO:1990845]; ADP transport [GO:0015866]; apoptotic mitochondrial changes [GO:0008637]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; mitochondrial genome maintenance [GO:0000002]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of necroptotic process [GO:0060546]; positive regulation of mitophagy [GO:1901526]; regulation of mitochondrial membrane permeability [GO:0046902]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21586654}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:27641616}; Multi-pass membrane protein {ECO:0000255}. Note=The complex formed with ARL2BP, ARL2 and SLC25A4/ANT1 is expressed in mitochondria (By similarity). May localize to non-mitochondrial membranes (PubMed:27641616). {ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:27641616}.
P12236	reviewed	ADT3_HUMAN	ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed]	SLC25A6 AAC3 ANT3 CDABP0051	Homo sapiens (Human)	298	FUNCTION: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:15033708). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:15033708). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:15033708}.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes and escapes X-inactivation. {ECO:0000269|PubMed:8486369}.	apoptotic process [GO:0006915]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	ATP:ADP antiporter activity [GO:0005471]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; ATP:ADP antiporter activity [GO:0005471]; apoptotic process [GO:0006915]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P02722}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:27641616}; Multi-pass membrane protein {ECO:0000255}. Note=The complex formed with ARL2BP, ARL2 and SLC25A6/ANT3 is expressed in mitochondria (By similarity). May localize to non-mitochondrial membranes (By similarity). {ECO:0000250|UniProtKB:P12235}.
P12259	reviewed	FA5_HUMAN	Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]	F5	Homo sapiens (Human)	2224	FUNCTION: Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.		blood circulation [GO:0008015]; blood coagulation [GO:0007596]; response to vitamin K [GO:0032571]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]	copper ion binding [GO:0005507]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; copper ion binding [GO:0005507]; blood circulation [GO:0008015]; blood coagulation [GO:0007596]; response to vitamin K [GO:0032571]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
P12268	reviewed	IMDH2_HUMAN	Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II)	IMPDH2 IMPD2	Homo sapiens (Human)	514	FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7903306, PubMed:7763314). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}.	MISCELLANEOUS: Because IMPDH activity is tightly linked with cell proliferation, it has been recognized as a target for cancer and viral chemotherapy and as a target for immunosuppressive drugs. The activities of the antitumor drug tiazofurin, the antiviral drug ribavirin, and the immunosuppressive drugs mizoribine and mycophenolic acid (MPA) are attributed to the inhibition of IMPDH. In addition, bacterial and parasitic IMPDH's differ significantly from mammalian enzymes, which makes it a suitable target for anti-infective drugs.	'de novo' XMP biosynthetic process [GO:0097294]; cellular response to interleukin-4 [GO:0071353]; circadian rhythm [GO:0007623]; GMP biosynthetic process [GO:0006177]; GTP biosynthetic process [GO:0006183]; lymphocyte proliferation [GO:0046651]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; secretory granule lumen [GO:0034774]	DNA binding [GO:0003677]; IMP dehydrogenase activity [GO:0003938]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; secretory granule lumen [GO:0034774]; DNA binding [GO:0003677]; IMP dehydrogenase activity [GO:0003938]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; 'de novo' XMP biosynthetic process [GO:0097294]; cellular response to interleukin-4 [GO:0071353]; circadian rhythm [GO:0007623]; GMP biosynthetic process [GO:0006177]; GTP biosynthetic process [GO:0006183]; lymphocyte proliferation [GO:0046651]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000269|PubMed:14766016}. Cytoplasm, cytosol {ECO:0000269|PubMed:31337707}. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion. {ECO:0000269|PubMed:24477477, ECO:0000269|PubMed:31337707}.
P12270	reviewed	TPR_HUMAN	Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)	TPR	Homo sapiens (Human)	2363	FUNCTION: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824, PubMed:11952838). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}.		cell division [GO:0051301]; cellular response to heat [GO:0034605]; cellular response to interferon-alpha [GO:0035457]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA export from nucleus [GO:0006406]; mRNA export from nucleus in response to heat stress [GO:0031990]; negative regulation of RNA export from nucleus [GO:0046832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translational initiation [GO:0045947]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of heterochromatin formation [GO:0031453]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus [GO:0006606]; regulation of mitotic sister chromatid separation [GO:0010965]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein localization [GO:0032880]; response to epidermal growth factor [GO:0070849]; RNA export from nucleus [GO:0006405]; RNA import into nucleus [GO:0006404]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; heat shock protein binding [GO:0031072]; mitogen-activated protein kinase binding [GO:0051019]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; structural constituent of nuclear pore [GO:0017056]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; heat shock protein binding [GO:0031072]; mitogen-activated protein kinase binding [GO:0051019]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; structural constituent of nuclear pore [GO:0017056]; tubulin binding [GO:0015631]; cell division [GO:0051301]; cellular response to heat [GO:0034605]; cellular response to interferon-alpha [GO:0035457]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA export from nucleus [GO:0006406]; mRNA export from nucleus in response to heat stress [GO:0031990]; negative regulation of RNA export from nucleus [GO:0046832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translational initiation [GO:0045947]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of heterochromatin formation [GO:0031453]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus [GO:0006606]; regulation of mitotic sister chromatid separation [GO:0010965]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein localization [GO:0032880]; response to epidermal growth factor [GO:0070849]; RNA export from nucleus [GO:0006405]; RNA import into nucleus [GO:0006404]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12802065}. Nucleus membrane {ECO:0000269|PubMed:11514627, ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:9024684, ECO:0000269|PubMed:9828100, ECO:0000269|PubMed:9864356}; Peripheral membrane protein {ECO:0000269|PubMed:11514627, ECO:0000269|PubMed:9024684, ECO:0000269|PubMed:9828100, ECO:0000269|PubMed:9864356}; Nucleoplasmic side {ECO:0000269|PubMed:11514627, ECO:0000269|PubMed:9024684, ECO:0000269|PubMed:9828100, ECO:0000269|PubMed:9864356}. Nucleus envelope {ECO:0000269|PubMed:12424524, ECO:0000269|PubMed:7798308}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:11514627, ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:7798308, ECO:0000269|PubMed:9024684, ECO:0000269|PubMed:9828100, ECO:0000269|PubMed:9864356}. Cytoplasm {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:12802065}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19273613}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:18981471}. Nucleus membrane {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:7798308}; Peripheral membrane protein {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:7798308}; Cytoplasmic side {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:7798308}. Note=Detected as discrete intranuclear foci with IFI204 (By similarity). In interphase, localizes to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Detected exclusively to the cytoplasmic margin of NPC (PubMed:7798308). Docking to the inner nucleoplasmic side of the NPC is mediated through binding to nucleoporins. Anchored by NUP153 to the NPC. The assembly of the NPC is a stepwise process in which Trp-containing peripheral structures assemble after other components, including p62. Detected as filaments that emanate from the nuclear basket of the NPC and extend to the nucleolus to delineate a chromatin-free network extending from the nuclear envelope to the perinucleolar region. Detected in diffuse and discrete spheroidal intranuclear foci. Nucleocytoplasmic shuttling protein imported into the nucleus in a XPO1/CRM1- and Importin alpha/Importin beta receptor-dependent manner. Remains localized to the nuclear membrane after poliovirus (PV) infection. During mitosis, remains associated with the nuclear envelope until prometaphase. Associated with the mitotic spindle from late prometaphase until anaphase. Reorganized during mitosis in a viscous and dynamic nuclear-derived spindle matrix that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner. Recruited to the reforming nuclear envelope during telophase and cytokinesis. Detected at kinetochores during prometaphase (PubMed:18981471). Colocalizes with MAD2L1 in the spindle matrix but not at kinetochore (PubMed:19273613). Colocalizes with dynein, dynactin, tubulin at kinetochore during the metaphase-anaphase transition. Colocalizes with DYNLL1 at the mitotic spindle. {ECO:0000250, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:7798308}.
P12271	reviewed	RLBP1_HUMAN	Retinaldehyde-binding protein 1 (Cellular retinaldehyde-binding protein)	RLBP1 CRALBP	Homo sapiens (Human)	317	FUNCTION: Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. {ECO:0000269|PubMed:19846785}.		response to stimulus [GO:0050896]; visual perception [GO:0007601]; vitamin A metabolic process [GO:0006776]	cell body [GO:0044297]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	11-cis retinal binding [GO:0005502]; phosphatidylinositol bisphosphate binding [GO:1902936]; retinol binding [GO:0019841]	cell body [GO:0044297]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; 11-cis retinal binding [GO:0005502]; phosphatidylinositol bisphosphate binding [GO:1902936]; retinol binding [GO:0019841]; response to stimulus [GO:0050896]; visual perception [GO:0007601]; vitamin A metabolic process [GO:0006776]	SUBCELLULAR LOCATION: Cytoplasm.
P12272	reviewed	PTHR_HUMAN	Parathyroid hormone-related protein (PTH-rP) (PTHrP) (Parathyroid hormone-like protein) (PLP) [Cleaved into: PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])]	PTHLH PTHRP	Homo sapiens (Human)	177	FUNCTION: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1. {ECO:0000250, ECO:0000269|PubMed:20637541}.; FUNCTION: Osteostatin is a potent inhibitor of osteoclastic bone resorption. {ECO:0000269|PubMed:20637541}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone mineralization [GO:0030282]; cAMP metabolic process [GO:0046058]; cell-cell signaling [GO:0007267]; epidermis development [GO:0008544]; female pregnancy [GO:0007565]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte development [GO:0061182]; negative regulation of chondrocyte differentiation [GO:0032331]; osteoblast development [GO:0002076]; positive regulation of cell population proliferation [GO:0008284]; regulation of chondrocyte differentiation [GO:0032330]; regulation of gene expression [GO:0010468]; skeletal system development [GO:0001501]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	hormone activity [GO:0005179]; peptide hormone receptor binding [GO:0051428]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; hormone activity [GO:0005179]; peptide hormone receptor binding [GO:0051428]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone mineralization [GO:0030282]; cAMP metabolic process [GO:0046058]; cell-cell signaling [GO:0007267]; epidermis development [GO:0008544]; female pregnancy [GO:0007565]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte development [GO:0061182]; negative regulation of chondrocyte differentiation [GO:0032331]; osteoblast development [GO:0002076]; positive regulation of cell population proliferation [GO:0008284]; regulation of chondrocyte differentiation [GO:0032330]; regulation of gene expression [GO:0010468]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Secreted.
P12273	reviewed	PIP_HUMAN	Prolactin-inducible protein (Gross cystic disease fluid protein 15) (GCDFP-15) (Prolactin-induced protein) (Secretory actin-binding protein) (SABP) (gp17)	PIP GCDFP15 GPIP4	Homo sapiens (Human)	146			detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of gene expression [GO:0010628]; proteolysis [GO:0006508]; regulation of immune system process [GO:0002682]; retina homeostasis [GO:0001895]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]	actin binding [GO:0003779]; aspartic-type endopeptidase activity [GO:0004190]; identical protein binding [GO:0042802]; IgG binding [GO:0019864]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; actin binding [GO:0003779]; aspartic-type endopeptidase activity [GO:0004190]; identical protein binding [GO:0042802]; IgG binding [GO:0019864]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of gene expression [GO:0010628]; proteolysis [GO:0006508]; regulation of immune system process [GO:0002682]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Secreted.
P12277	reviewed	KCRB_HUMAN	Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B)	CKB CKBB	Homo sapiens (Human)	381	FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}.		futile creatine cycle [GO:0140651]; phosphocreatine biosynthetic process [GO:0046314]; phosphorylation [GO:0016310]; substantia nigra development [GO:0021762]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; ubiquitin protein ligase binding [GO:0031625]; futile creatine cycle [GO:0140651]; phosphocreatine biosynthetic process [GO:0046314]; phosphorylation [GO:0016310]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04447}. Mitochondrion {ECO:0000250|UniProtKB:Q04447}. Cell membrane {ECO:0000269|PubMed:18566107}. Note=Localizes to the mitochondria of thermogenic fat cells via the internal MTS-like signal (iMTS-L) region. {ECO:0000250|UniProtKB:Q04447}.
P12314	reviewed	FCGR1_HUMAN	High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)	FCGR1A FCG1 FCGR1 IGFR1	Homo sapiens (Human)	374	FUNCTION: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells. {ECO:0000269|PubMed:10397749, ECO:0000269|PubMed:10514529, ECO:0000269|PubMed:11711607, ECO:0000269|PubMed:21965667, ECO:0000269|PubMed:8611682, ECO:0000269|PubMed:9881690}.		antibody-dependent cellular cytotoxicity [GO:0001788]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; cell surface receptor signaling pathway [GO:0007166]; defense response to bacterium [GO:0042742]; immune response [GO:0006955]; innate immune response [GO:0045087]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of type IIa hypersensitivity [GO:0001798]; positive regulation of type III hypersensitivity [GO:0001805]; receptor-mediated endocytosis [GO:0006898]; regulation of immune response [GO:0050776]; signal transduction [GO:0007165]	clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome membrane [GO:0031901]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	high-affinity IgG receptor activity [GO:0019771]; IgG binding [GO:0019864]; transmembrane signaling receptor activity [GO:0004888]	clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome membrane [GO:0031901]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; high-affinity IgG receptor activity [GO:0019771]; IgG binding [GO:0019864]; transmembrane signaling receptor activity [GO:0004888]; antibody-dependent cellular cytotoxicity [GO:0001788]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; cell surface receptor signaling pathway [GO:0007166]; defense response to bacterium [GO:0042742]; immune response [GO:0006955]; innate immune response [GO:0045087]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of type IIa hypersensitivity [GO:0001798]; positive regulation of type III hypersensitivity [GO:0001805]; receptor-mediated endocytosis [GO:0006898]; regulation of immune response [GO:0050776]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}. Note=Stabilized at the cell membrane through interaction with FCER1G.
P12318	reviewed	FCG2A_HUMAN	Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32)	FCGR2A CD32 FCG2 FCGR2A1 IGFR2	Homo sapiens (Human)	317	FUNCTION: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. {ECO:0000269|PubMed:19011614}.		cell surface receptor signaling pathway [GO:0007166]; immune system process [GO:0002376]; regulation of immune response [GO:0050776]	plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	IgG binding [GO:0019864]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; IgG binding [GO:0019864]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; immune system process [GO:0002376]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19011614}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011614}.
P12319	reviewed	FCERA_HUMAN	High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha)	FCER1A FCE1A	Homo sapiens (Human)	257	FUNCTION: High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. {ECO:0000269|PubMed:8114916, ECO:0000269|PubMed:8551243}.		cell surface receptor signaling pathway [GO:0007166]; eosinophil degranulation [GO:0043308]; mast cell degranulation [GO:0043303]; regulation of immune response [GO:0050776]; type 2 immune response [GO:0042092]; type I hypersensitivity [GO:0016068]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	high-affinity IgE receptor activity [GO:0019768]; IgE binding [GO:0019863]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; high-affinity IgE receptor activity [GO:0019768]; IgE binding [GO:0019863]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; eosinophil degranulation [GO:0043308]; mast cell degranulation [GO:0043303]; regulation of immune response [GO:0050776]; type 2 immune response [GO:0042092]; type I hypersensitivity [GO:0016068]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8114916}; Single-pass type I membrane protein.
P12429	reviewed	ANXA3_HUMAN	Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)	ANXA3 ANX3	Homo sapiens (Human)	323	FUNCTION: Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.		animal organ regeneration [GO:0031100]; defense response to bacterium [GO:0042742]; hippocampus development [GO:0021766]; neutrophil degranulation [GO:0043312]; phagocytosis [GO:0006909]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA metabolic process [GO:0051054]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell migration [GO:0010595]; response to glucocorticoid [GO:0051384]; response to growth factor [GO:0070848]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; specific granule [GO:0042581]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; phospholipase A2 inhibitor activity [GO:0019834]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; specific granule [GO:0042581]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; phospholipase A2 inhibitor activity [GO:0019834]; animal organ regeneration [GO:0031100]; defense response to bacterium [GO:0042742]; hippocampus development [GO:0021766]; neutrophil degranulation [GO:0043312]; phagocytosis [GO:0006909]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA metabolic process [GO:0051054]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell migration [GO:0010595]; response to glucocorticoid [GO:0051384]; response to growth factor [GO:0070848]	
P12524	reviewed	MYCL_HUMAN	Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog)	MYCL BHLHE38 LMYC MYCL1	Homo sapiens (Human)	364			regulation of inner ear auditory receptor cell differentiation [GO:0045607]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of inner ear auditory receptor cell differentiation [GO:0045607]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:2548855}.
P12532	reviewed	KCRU_HUMAN	Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK)	CKMT1A CKMT; CKMT1B CKMT	Homo sapiens (Human)	417	FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.	MISCELLANEOUS: Mitochondrial creatine kinase binds cardiolipin.	phosphocreatine biosynthetic process [GO:0046314]; phosphorylation [GO:0016310]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; phosphocreatine biosynthetic process [GO:0046314]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
P12544	reviewed	GRAA_HUMAN	Granzyme A (EC 3.4.21.78) (CTL tryptase) (Cytotoxic T-lymphocyte proteinase 1) (Fragmentin-1) (Granzyme-1) (Hanukkah factor) (H factor) (HF)	GZMA CTLA3 HFSP	Homo sapiens (Human)	262	FUNCTION: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3257574, PubMed:3262682, PubMed:3263427, PubMed:32299851, PubMed:12819770). It cleaves after Lys or Arg (PubMed:32299851, PubMed:12819770). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death (PubMed:32299851, PubMed:34022140, PubMed:36157507, PubMed:36899106). Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity (PubMed:12524539). Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (PubMed:11555662, PubMed:12628186, PubMed:16818237). {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:12819770, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:32299851, ECO:0000269|PubMed:3257574, ECO:0000269|PubMed:3262682, ECO:0000269|PubMed:3263427, ECO:0000269|PubMed:34022140, ECO:0000269|PubMed:36157507, ECO:0000269|PubMed:36899106}.		apoptotic process [GO:0006915]; cytotoxic T cell pyroptotic process [GO:1902483]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; immune response [GO:0006955]; killing of cells of another organism [GO:0031640]; negative regulation of DNA binding [GO:0043392]; negative regulation of endodeoxyribonuclease activity [GO:0032078]; negative regulation of oxidoreductase activity [GO:0051354]; positive regulation of apoptotic process [GO:0043065]; protein maturation [GO:0051604]; proteolysis involved in protein catabolic process [GO:0051603]; pyroptosis [GO:0070269]; response to bacterium [GO:0009617]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; immunological synapse [GO:0001772]; nucleus [GO:0005634]	protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; immunological synapse [GO:0001772]; nucleus [GO:0005634]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]; apoptotic process [GO:0006915]; cytotoxic T cell pyroptotic process [GO:1902483]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; immune response [GO:0006955]; killing of cells of another organism [GO:0031640]; negative regulation of DNA binding [GO:0043392]; negative regulation of endodeoxyribonuclease activity [GO:0032078]; negative regulation of oxidoreductase activity [GO:0051354]; positive regulation of apoptotic process [GO:0043065]; protein maturation [GO:0051604]; proteolysis involved in protein catabolic process [GO:0051603]; pyroptosis [GO:0070269]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: [Isoform alpha]: Secreted {ECO:0000269|PubMed:3257574}. Cytoplasmic granule {ECO:0000269|PubMed:3257574}. Note=Delivered into the target cell by perforin. {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:32299851}.
P12643	reviewed	BMP2_HUMAN	Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)	BMP2 BMP2A	Homo sapiens (Human)	396	FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis (PubMed:18436533, PubMed:31019025, PubMed:24362451). Induces cartilage and bone formation (PubMed:3201241). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:15064755, PubMed:17295905, PubMed:18436533). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A (PubMed:7791754). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3 (PubMed:31800957). Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation (PubMed:20851880, PubMed:16771708). Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). {ECO:0000250|UniProtKB:P21274, ECO:0000269|PubMed:15064755, ECO:0000269|PubMed:17295905, ECO:0000269|PubMed:18436533, ECO:0000269|PubMed:20851880, ECO:0000269|PubMed:24362451, ECO:0000269|PubMed:31019025, ECO:0000269|PubMed:31800957, ECO:0000269|PubMed:3201241, ECO:0000269|PubMed:7791754}.		ameloblast differentiation [GO:0036305]; animal organ morphogenesis [GO:0009887]; aortic valve development [GO:0003176]; astrocyte differentiation [GO:0048708]; atrioventricular canal morphogenesis [GO:1905222]; atrioventricular valve morphogenesis [GO:0003181]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; bone mineralization [GO:0030282]; branching involved in ureteric bud morphogenesis [GO:0001658]; cardiac atrium formation [GO:0003210]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac jelly development [GO:1905072]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiocyte differentiation [GO:0035051]; cell fate commitment [GO:0045165]; cell-cell signaling [GO:0007267]; cellular response to BMP stimulus [GO:0071773]; cellular response to organic cyclic compound [GO:0071407]; chondrocyte differentiation [GO:0002062]; corticotropin hormone secreting cell differentiation [GO:0060128]; embryonic heart tube anterior/posterior pattern specification [GO:0035054]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; endodermal-mesodermal cell signaling [GO:0003133]; epithelial to mesenchymal transition [GO:0001837]; heart development [GO:0007507]; heart induction [GO:0003129]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; inner ear development [GO:0048839]; lung vasculature development [GO:0060426]; mesenchymal cell differentiation [GO:0048762]; mesenchymal cell proliferation involved in ureteric bud development [GO:0072138]; mesenchyme development [GO:0060485]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of calcium-independent cell-cell adhesion [GO:0051042]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of Wnt signaling pathway involved in heart development [GO:0003308]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; pericardium development [GO:0060039]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of bone mineralization [GO:0030501]; positive regulation of bone mineralization involved in bone maturation [GO:1900159]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of odontogenesis [GO:0042482]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of phosphatase activity [GO:0010922]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of Wnt signaling pathway [GO:0030177]; protein destabilization [GO:0031648]; proteoglycan metabolic process [GO:0006029]; regulation of DNA-templated transcription [GO:0006355]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; response to bacterium [GO:0009617]; response to hypoxia [GO:0001666]; skeletal system development [GO:0001501]; telencephalon development [GO:0021537]; telencephalon regionalization [GO:0021978]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; transcription by RNA polymerase II [GO:0006366]	BMP receptor complex [GO:0070724]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]	BMP receptor binding [GO:0070700]; co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; phosphatase activator activity [GO:0019211]; protein serine/threonine kinase activator activity [GO:0043539]; signaling receptor binding [GO:0005102]; SMAD binding [GO:0046332]	BMP receptor complex [GO:0070724]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; BMP receptor binding [GO:0070700]; co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; phosphatase activator activity [GO:0019211]; protein serine/threonine kinase activator activity [GO:0043539]; signaling receptor binding [GO:0005102]; SMAD binding [GO:0046332]; ameloblast differentiation [GO:0036305]; animal organ morphogenesis [GO:0009887]; aortic valve development [GO:0003176]; astrocyte differentiation [GO:0048708]; atrioventricular canal morphogenesis [GO:1905222]; atrioventricular valve morphogenesis [GO:0003181]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; bone mineralization [GO:0030282]; branching involved in ureteric bud morphogenesis [GO:0001658]; cardiac atrium formation [GO:0003210]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac jelly development [GO:1905072]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiocyte differentiation [GO:0035051]; cell fate commitment [GO:0045165]; cell-cell signaling [GO:0007267]; cellular response to BMP stimulus [GO:0071773]; cellular response to organic cyclic compound [GO:0071407]; chondrocyte differentiation [GO:0002062]; corticotropin hormone secreting cell differentiation [GO:0060128]; embryonic heart tube anterior/posterior pattern specification [GO:0035054]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; endodermal-mesodermal cell signaling [GO:0003133]; epithelial to mesenchymal transition [GO:0001837]; heart development [GO:0007507]; heart induction [GO:0003129]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; inner ear development [GO:0048839]; lung vasculature development [GO:0060426]; mesenchymal cell differentiation [GO:0048762]; mesenchymal cell proliferation involved in ureteric bud development [GO:0072138]; mesenchyme development [GO:0060485]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of calcium-independent cell-cell adhesion [GO:0051042]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of Wnt signaling pathway involved in heart development [GO:0003308]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; pericardium development [GO:0060039]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of bone mineralization [GO:0030501]; positive regulation of bone mineralization involved in bone maturation [GO:1900159]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of odontogenesis [GO:0042482]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of phosphatase activity [GO:0010922]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of Wnt signaling pathway [GO:0030177]; protein destabilization [GO:0031648]; proteoglycan metabolic process [GO:0006029]; regulation of DNA-templated transcription [GO:0006355]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; response to bacterium [GO:0009617]; response to hypoxia [GO:0001666]; skeletal system development [GO:0001501]; telencephalon development [GO:0021537]; telencephalon regionalization [GO:0021978]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Secreted.
P12644	reviewed	BMP4_HUMAN	Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)	BMP4 BMP2B DVR4	Homo sapiens (Human)	408	FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (PubMed:31363885). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:25868050, PubMed:8006002). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:25868050, PubMed:29212066). Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus (By similarity). Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades (PubMed:31363885). For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (PubMed:31363885). {ECO:0000250|UniProtKB:P21275, ECO:0000269|PubMed:25868050, ECO:0000269|PubMed:29212066, ECO:0000269|PubMed:31363885, ECO:0000269|PubMed:8006002}.		ameloblast differentiation [GO:0036305]; anterior/posterior axis specification [GO:0009948]; aortic valve morphogenesis [GO:0003180]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; BMP signaling pathway [GO:0030509]; branching involved in prostate gland morphogenesis [GO:0060442]; branching involved in ureteric bud morphogenesis [GO:0001658]; bronchus development [GO:0060433]; bud dilation involved in lung branching [GO:0060503]; bud elongation involved in lung branching [GO:0060449]; cardiac muscle cell differentiation [GO:0055007]; cardiac septum development [GO:0003279]; cellular response to BMP stimulus [GO:0071773]; chondrocyte differentiation [GO:0002062]; coronary vasculature development [GO:0060976]; cranial suture morphogenesis [GO:0060363]; deltoid tuberosity development [GO:0035993]; dorsal/ventral neural tube patterning [GO:0021904]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal joint morphogenesis [GO:0060272]; endocardial cushion development [GO:0003197]; endochondral ossification [GO:0001958]; endoderm development [GO:0007492]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; epithelial-mesenchymal cell signaling [GO:0060684]; erythrocyte differentiation [GO:0030218]; germ cell development [GO:0007281]; glomerular capillary formation [GO:0072104]; heart induction [GO:0003129]; heart morphogenesis [GO:0003007]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear auditory receptor cell differentiation [GO:0042491]; intermediate mesodermal cell differentiation [GO:0048392]; kidney development [GO:0001822]; lens induction in camera-type eye [GO:0060235]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; lung vasculature development [GO:0060426]; lymphoid progenitor cell differentiation [GO:0002320]; macrophage differentiation [GO:0030225]; mammary gland formation [GO:0060592]; membranous septum morphogenesis [GO:0003149]; mesodermal cell fate determination [GO:0007500]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; monocyte differentiation [GO:0030224]; negative regulation of branching involved in ureteric bud morphogenesis [GO:0090191]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gene expression [GO:0010629]; negative regulation of glomerular mesangial cell proliferation [GO:0072125]; negative regulation of glomerulus development [GO:0090194]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of mesenchymal cell proliferation involved in ureter development [GO:0072200]; negative regulation of metanephric comma-shaped body morphogenesis [GO:2000007]; negative regulation of metanephric S-shaped body morphogenesis [GO:2000005]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of mitotic nuclear division [GO:0045839]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of T cell differentiation in thymus [GO:0033085]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; nephric duct formation [GO:0072179]; neural tube closure [GO:0001843]; neuron fate commitment [GO:0048663]; odontogenesis [GO:0042476]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; outflow tract septum morphogenesis [GO:0003148]; pericyte cell differentiation [GO:1904238]; pharyngeal arch artery morphogenesis [GO:0061626]; pituitary gland development [GO:0021983]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of branching involved in lung morphogenesis [GO:0061047]; positive regulation of cardiac muscle fiber development [GO:0055020]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of primary miRNA processing [GO:2000636]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; prostatic bud formation [GO:0060513]; pulmonary valve morphogenesis [GO:0003184]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of cell fate commitment [GO:0010453]; regulation of mesodermal cell differentiation [GO:1905770]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of protein import into nucleus [GO:0042306]; regulation of smooth muscle cell differentiation [GO:0051150]; renal system process [GO:0003014]; secondary heart field specification [GO:0003139]; sinoatrial node development [GO:0003163]; SMAD protein signal transduction [GO:0060395]; smooth muscle cell differentiation [GO:0051145]; smooth muscle tissue development [GO:0048745]; specification of animal organ position [GO:0010159]; telencephalon development [GO:0021537]; telencephalon regionalization [GO:0021978]; tendon cell differentiation [GO:0035990]; trachea development [GO:0060438]; trachea formation [GO:0060440]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell development [GO:0003323]; ureter morphogenesis [GO:0072197]; ureteric bud development [GO:0001657]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	BMP receptor binding [GO:0070700]; chemoattractant activity [GO:0042056]; co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; BMP receptor binding [GO:0070700]; chemoattractant activity [GO:0042056]; co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; ameloblast differentiation [GO:0036305]; anterior/posterior axis specification [GO:0009948]; aortic valve morphogenesis [GO:0003180]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; BMP signaling pathway [GO:0030509]; branching involved in prostate gland morphogenesis [GO:0060442]; branching involved in ureteric bud morphogenesis [GO:0001658]; bronchus development [GO:0060433]; bud dilation involved in lung branching [GO:0060503]; bud elongation involved in lung branching [GO:0060449]; cardiac muscle cell differentiation [GO:0055007]; cardiac septum development [GO:0003279]; cellular response to BMP stimulus [GO:0071773]; chondrocyte differentiation [GO:0002062]; coronary vasculature development [GO:0060976]; cranial suture morphogenesis [GO:0060363]; deltoid tuberosity development [GO:0035993]; dorsal/ventral neural tube patterning [GO:0021904]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal joint morphogenesis [GO:0060272]; endocardial cushion development [GO:0003197]; endochondral ossification [GO:0001958]; endoderm development [GO:0007492]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; epithelial-mesenchymal cell signaling [GO:0060684]; erythrocyte differentiation [GO:0030218]; germ cell development [GO:0007281]; glomerular capillary formation [GO:0072104]; heart induction [GO:0003129]; heart morphogenesis [GO:0003007]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear auditory receptor cell differentiation [GO:0042491]; intermediate mesodermal cell differentiation [GO:0048392]; kidney development [GO:0001822]; lens induction in camera-type eye [GO:0060235]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; lung vasculature development [GO:0060426]; lymphoid progenitor cell differentiation [GO:0002320]; macrophage differentiation [GO:0030225]; mammary gland formation [GO:0060592]; membranous septum morphogenesis [GO:0003149]; mesodermal cell fate determination [GO:0007500]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; monocyte differentiation [GO:0030224]; negative regulation of branching involved in ureteric bud morphogenesis [GO:0090191]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gene expression [GO:0010629]; negative regulation of glomerular mesangial cell proliferation [GO:0072125]; negative regulation of glomerulus development [GO:0090194]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of mesenchymal cell proliferation involved in ureter development [GO:0072200]; negative regulation of metanephric comma-shaped body morphogenesis [GO:2000007]; negative regulation of metanephric S-shaped body morphogenesis [GO:2000005]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of mitotic nuclear division [GO:0045839]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of T cell differentiation in thymus [GO:0033085]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; nephric duct formation [GO:0072179]; neural tube closure [GO:0001843]; neuron fate commitment [GO:0048663]; odontogenesis [GO:0042476]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; outflow tract septum morphogenesis [GO:0003148]; pericyte cell differentiation [GO:1904238]; pharyngeal arch artery morphogenesis [GO:0061626]; pituitary gland development [GO:0021983]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of branching involved in lung morphogenesis [GO:0061047]; positive regulation of cardiac muscle fiber development [GO:0055020]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of primary miRNA processing [GO:2000636]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; prostatic bud formation [GO:0060513]; pulmonary valve morphogenesis [GO:0003184]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of cell fate commitment [GO:0010453]; regulation of mesodermal cell differentiation [GO:1905770]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of protein import into nucleus [GO:0042306]; regulation of smooth muscle cell differentiation [GO:0051150]; renal system process [GO:0003014]; secondary heart field specification [GO:0003139]; sinoatrial node development [GO:0003163]; SMAD protein signal transduction [GO:0060395]; smooth muscle cell differentiation [GO:0051145]; smooth muscle tissue development [GO:0048745]; specification of animal organ position [GO:0010159]; telencephalon development [GO:0021537]; telencephalon regionalization [GO:0021978]; tendon cell differentiation [GO:0035990]; trachea development [GO:0060438]; trachea formation [GO:0060440]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell development [GO:0003323]; ureter morphogenesis [GO:0072197]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
P12645	reviewed	BMP3_HUMAN	Bone morphogenetic protein 3 (BMP-3) (Bone morphogenetic protein 3A) (BMP-3A) (Osteogenin)	BMP3 BMP3A	Homo sapiens (Human)	472	FUNCTION: Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification (PubMed:11138004, PubMed:15269709). Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways (PubMed:31665064). {ECO:0000269|PubMed:11138004, ECO:0000269|PubMed:15269709, ECO:0000269|PubMed:31665064}.		cartilage development [GO:0051216]; cell-cell signaling [GO:0007267]; osteoblast differentiation [GO:0001649]; skeletal system development [GO:0001501]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102]; cartilage development [GO:0051216]; cell-cell signaling [GO:0007267]; osteoblast differentiation [GO:0001649]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted.
P12694	reviewed	ODBA_HUMAN	2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha)	BCKDHA	Homo sapiens (Human)	445	FUNCTION: Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. {ECO:0000269|PubMed:10745006, ECO:0000269|PubMed:7883996, ECO:0000269|PubMed:9582350}.		branched-chain amino acid catabolic process [GO:0009083]	mitochondrial alpha-ketoglutarate dehydrogenase complex [GO:0005947]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity [GO:0003863]; carboxy-lyase activity [GO:0016831]; metal ion binding [GO:0046872]	mitochondrial alpha-ketoglutarate dehydrogenase complex [GO:0005947]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity [GO:0003863]; carboxy-lyase activity [GO:0016831]; metal ion binding [GO:0046872]; branched-chain amino acid catabolic process [GO:0009083]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:10745006}.
P12724	reviewed	ECP_HUMAN	Eosinophil cationic protein (ECP) (EC 3.1.27.-) (Ribonuclease 3) (RNase 3)	RNASE3 ECP RNS3	Homo sapiens (Human)	160	FUNCTION: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. {ECO:0000269|PubMed:19450231, ECO:0000269|PubMed:2501794}.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chemotaxis [GO:0006935]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; RNA catabolic process [GO:0006401]	azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	endonuclease activity [GO:0004519]; lipopolysaccharide binding [GO:0001530]; nucleic acid binding [GO:0003676]; RNA nuclease activity [GO:0004540]	azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; endonuclease activity [GO:0004519]; lipopolysaccharide binding [GO:0001530]; nucleic acid binding [GO:0003676]; RNA nuclease activity [GO:0004540]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chemotaxis [GO:0006935]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; RNA catabolic process [GO:0006401]	SUBCELLULAR LOCATION: Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
P12755	reviewed	SKI_HUMAN	Ski oncogene (Proto-oncogene c-Ski)	SKI	Homo sapiens (Human)	728	FUNCTION: May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}.		anterior/posterior axis specification [GO:0009948]; bone morphogenesis [GO:0060349]; camera-type eye development [GO:0043010]; camera-type eye morphogenesis [GO:0048593]; cardiac muscle cell proliferation [GO:0060038]; cell motility [GO:0048870]; embryonic limb morphogenesis [GO:0030326]; face morphogenesis [GO:0060325]; lens morphogenesis in camera-type eye [GO:0002089]; myelination in peripheral nervous system [GO:0022011]; myotube differentiation [GO:0014902]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neural tube closure [GO:0001843]; nose morphogenesis [GO:0043585]; olfactory bulb development [GO:0021772]; positive regulation of DNA binding [GO:0043388]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; retina development in camera-type eye [GO:0060041]; roof of mouth development [GO:0060021]; skeletal muscle fiber development [GO:0048741]; SMAD protein signal transduction [GO:0060395]; somatic stem cell population maintenance [GO:0035019]; transforming growth factor beta receptor signaling pathway [GO:0007179]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase inhibitor activity [GO:0046811]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase inhibitor activity [GO:0046811]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; anterior/posterior axis specification [GO:0009948]; bone morphogenesis [GO:0060349]; camera-type eye development [GO:0043010]; camera-type eye morphogenesis [GO:0048593]; cardiac muscle cell proliferation [GO:0060038]; cell motility [GO:0048870]; embryonic limb morphogenesis [GO:0030326]; face morphogenesis [GO:0060325]; lens morphogenesis in camera-type eye [GO:0002089]; myelination in peripheral nervous system [GO:0022011]; myotube differentiation [GO:0014902]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neural tube closure [GO:0001843]; nose morphogenesis [GO:0043585]; olfactory bulb development [GO:0021772]; positive regulation of DNA binding [GO:0043388]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; retina development in camera-type eye [GO:0060041]; roof of mouth development [GO:0060021]; skeletal muscle fiber development [GO:0048741]; SMAD protein signal transduction [GO:0060395]; somatic stem cell population maintenance [GO:0035019]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Nucleus.
P12757	reviewed	SKIL_HUMAN	Ski-like protein (Ski-related oncogene) (Ski-related protein)	SKIL SNO	Homo sapiens (Human)	684	FUNCTION: May have regulatory role in cell division or differentiation in response to extracellular signals.		blastocyst formation [GO:0001825]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lens fiber cell differentiation [GO:0070306]; lymphocyte homeostasis [GO:0002260]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell differentiation [GO:0045596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of axonogenesis [GO:0050772]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; regulation of cell cycle [GO:0051726]; response to antibiotic [GO:0046677]; response to cytokine [GO:0034097]; response to growth factor [GO:0070848]; skeletal muscle tissue development [GO:0007519]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332]; blastocyst formation [GO:0001825]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lens fiber cell differentiation [GO:0070306]; lymphocyte homeostasis [GO:0002260]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell differentiation [GO:0045596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of axonogenesis [GO:0050772]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; regulation of cell cycle [GO:0051726]; response to antibiotic [GO:0046677]; response to cytokine [GO:0034097]; response to growth factor [GO:0070848]; skeletal muscle tissue development [GO:0007519]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179]	
P12814	reviewed	ACTN1_HUMAN	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)	ACTN1	Homo sapiens (Human)	892	FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.		actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; focal adhesion assembly [GO:0048041]; muscle cell development [GO:0055001]; platelet formation [GO:0030220]; platelet morphogenesis [GO:0036344]; regulation of apoptotic process [GO:0042981]	brush border [GO:0005903]; cell junction [GO:0030054]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fascia adherens [GO:0005916]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; pseudopodium [GO:0031143]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; double-stranded RNA binding [GO:0003725]; integrin binding [GO:0005178]; nuclear receptor coactivator activity [GO:0030374]; protein homodimerization activity [GO:0042803]; structural constituent of postsynapse [GO:0099186]; transmembrane transporter binding [GO:0044325]; vinculin binding [GO:0017166]	brush border [GO:0005903]; cell junction [GO:0030054]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fascia adherens [GO:0005916]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; pseudopodium [GO:0031143]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; double-stranded RNA binding [GO:0003725]; integrin binding [GO:0005178]; nuclear receptor coactivator activity [GO:0030374]; protein homodimerization activity [GO:0042803]; structural constituent of postsynapse [GO:0099186]; transmembrane transporter binding [GO:0044325]; vinculin binding [GO:0017166]; actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; focal adhesion assembly [GO:0048041]; muscle cell development [GO:0055001]; platelet formation [GO:0030220]; platelet morphogenesis [GO:0036344]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24069336, ECO:0000269|PubMed:7750553}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:7750553}. Cell membrane {ECO:0000250|UniProtKB:Q9Z1P2}. Cell junction {ECO:0000250|UniProtKB:Q9Z1P2}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q7TPR4}. Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures. {ECO:0000250|UniProtKB:Q7TPR4}.
P12821	reviewed	ACE_HUMAN	Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form]	ACE DCP DCP1	Homo sapiens (Human)	1306	FUNCTION: Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity (PubMed:2558109, PubMed:4322742, PubMed:7683654, PubMed:7523412, PubMed:15615692, PubMed:20826823). Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates (PubMed:1851160, PubMed:1320019, PubMed:7683654, PubMed:7876104, PubMed:10913258, PubMed:19773553). Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin (PubMed:4322742, PubMed:1851160, PubMed:11432860, PubMed:19773553, PubMed:23056909). Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response (PubMed:2558109, PubMed:6055465, PubMed:4322742, PubMed:6270633, PubMed:7683654, PubMed:15615692). Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins (PubMed:656131, PubMed:6270633, PubMed:6208535, PubMed:15615692). Catalyzes degradation of different enkephalin neuropeptides (Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Phe and possibly Met-enkephalin-Arg-Gly-Leu) (PubMed:656131, PubMed:6270633, PubMed:2982830). Acts as a regulator of synaptic plasticity in the nucleus accumbens of the brain by mediating cleavage of Met-enkephalin-Arg-Phe, a strong ligand of Mu-type opioid receptor OPRM1, into Met-enkephalin (By similarity). Met-enkephalin-Arg-Phe cleavage by ACE decreases activation of OPRM1, leading to long-term synaptic potentiation of glutamate release (By similarity). Also acts as a regulator of hematopoietic stem cell differentiation by mediating degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) (PubMed:8257427, PubMed:7876104, PubMed:8609242, PubMed:26403559). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (PubMed:18077343). Involved in amyloid-beta metabolism by catalyzing degradation of Amyloid-beta protein 40 and Amyloid-beta protein 42 peptides, thereby preventing plaque formation (PubMed:11604391, PubMed:16154999, PubMed:19773553). Catalyzes cleavage of cholecystokinin (maturation of Cholecystokinin-8 and Cholecystokinin-5) and Gonadoliberin-1 (both maturation and degradation) hormones (PubMed:2983326, PubMed:7683654, PubMed:9371719, PubMed:10336644). Degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) and amyloid-beta proteins is mediated by the N-terminal catalytic domain, while angiotensin I and cholecystokinin cleavage is mediated by the C-terminal catalytic region (PubMed:7876104, PubMed:10336644, PubMed:19773553). {ECO:0000250|UniProtKB:P09470, ECO:0000269|PubMed:10336644, ECO:0000269|PubMed:10913258, ECO:0000269|PubMed:11432860, ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:1320019, ECO:0000269|PubMed:15615692, ECO:0000269|PubMed:16154999, ECO:0000269|PubMed:18077343, ECO:0000269|PubMed:1851160, ECO:0000269|PubMed:19773553, ECO:0000269|PubMed:20826823, ECO:0000269|PubMed:23056909, ECO:0000269|PubMed:2558109, ECO:0000269|PubMed:26403559, ECO:0000269|PubMed:2982830, ECO:0000269|PubMed:2983326, ECO:0000269|PubMed:4322742, ECO:0000269|PubMed:6055465, ECO:0000269|PubMed:6208535, ECO:0000269|PubMed:6270633, ECO:0000269|PubMed:656131, ECO:0000269|PubMed:7523412, ECO:0000269|PubMed:7683654, ECO:0000269|PubMed:7876104, ECO:0000269|PubMed:8257427, ECO:0000269|PubMed:8609242, ECO:0000269|PubMed:9371719}.; FUNCTION: [Angiotensin-converting enzyme, soluble form]: Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region. {ECO:0000269|PubMed:10769174, ECO:0000269|PubMed:11274151, ECO:0000269|PubMed:7499427, ECO:0000269|PubMed:8253769}.; FUNCTION: [Isoform Testis-specific]: Isoform produced by alternative promoter usage that is specifically expressed in spermatocytes and adult testis, and which is required for male fertility (PubMed:1651327, PubMed:1668266). In contrast to somatic isoforms, only contains one catalytic domain (PubMed:1651327, PubMed:1668266). Acts as a dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of substrates (PubMed:1668266, PubMed:24297181). The identity of substrates that are needed for male fertility is unknown (By similarity). May also have a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. The GPIase activity was reported to be essential for the egg-binding ability of the sperm (By similarity). This activity is however unclear and has been challenged by other groups, suggesting that it may be indirect (By similarity). {ECO:0000250|UniProtKB:P09470, ECO:0000269|PubMed:1651327, ECO:0000269|PubMed:1668266, ECO:0000269|PubMed:24297181}.	MISCELLANEOUS: Inhibitors of ACE are commonly used to treat hypertension and some types of renal and cardiac dysfunction.; MISCELLANEOUS: [Isoform Somatic-2]: Incomplete sequence. {ECO:0000305}.	amyloid-beta metabolic process [GO:0050435]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; angiotensin maturation [GO:0002003]; animal organ regeneration [GO:0031100]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; arachidonic acid secretion [GO:0050482]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; bradykinin catabolic process [GO:0010815]; cell proliferation in bone marrow [GO:0071838]; cellular response to aldosterone [GO:1904045]; cellular response to glucose stimulus [GO:0071333]; eating behavior [GO:0042755]; embryo development ending in birth or egg hatching [GO:0009792]; female pregnancy [GO:0007565]; heart contraction [GO:0060047]; hematopoietic stem cell differentiation [GO:0060218]; hormone catabolic process [GO:0042447]; hormone metabolic process [GO:0042445]; kidney development [GO:0001822]; lung alveolus development [GO:0048286]; male gonad development [GO:0008584]; mononuclear cell proliferation [GO:0032943]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gap junction assembly [GO:1903597]; negative regulation of gene expression [GO:0010629]; negative regulation of glucose import [GO:0046325]; neutrophil mediated immunity [GO:0002446]; peptide catabolic process [GO:0043171]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neurogenesis [GO:0050769]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; post-transcriptional regulation of gene expression [GO:0010608]; proteolysis [GO:0006508]; regulation of angiotensin metabolic process [GO:0060177]; regulation of blood pressure [GO:0008217]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of renal output by angiotensin [GO:0002019]; regulation of smooth muscle cell migration [GO:0014910]; regulation of synaptic plasticity [GO:0048167]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; regulation of vasoconstriction [GO:0019229]; response to dexamethasone [GO:0071548]; response to hypoxia [GO:0001666]; response to laminar fluid shear stress [GO:0034616]; response to lipopolysaccharide [GO:0032496]; response to nutrient levels [GO:0031667]; response to thyroid hormone [GO:0097066]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]; substance P catabolic process [GO:0010814]; vasoconstriction [GO:0042310]	basal plasma membrane [GO:0009925]; brush border membrane [GO:0031526]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]	actin binding [GO:0003779]; bradykinin receptor binding [GO:0031711]; calmodulin binding [GO:0005516]; carboxypeptidase activity [GO:0004180]; chloride ion binding [GO:0031404]; endopeptidase activity [GO:0004175]; exopeptidase activity [GO:0008238]; heterocyclic compound binding [GO:1901363]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; mitogen-activated protein kinase binding [GO:0051019]; mitogen-activated protein kinase kinase binding [GO:0031434]; peptidase activity [GO:0008233]; peptidyl-dipeptidase activity [GO:0008241]; tripeptidyl-peptidase activity [GO:0008240]; zinc ion binding [GO:0008270]	basal plasma membrane [GO:0009925]; brush border membrane [GO:0031526]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]; actin binding [GO:0003779]; bradykinin receptor binding [GO:0031711]; calmodulin binding [GO:0005516]; carboxypeptidase activity [GO:0004180]; chloride ion binding [GO:0031404]; endopeptidase activity [GO:0004175]; exopeptidase activity [GO:0008238]; heterocyclic compound binding [GO:1901363]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; mitogen-activated protein kinase binding [GO:0051019]; mitogen-activated protein kinase kinase binding [GO:0031434]; peptidase activity [GO:0008233]; peptidyl-dipeptidase activity [GO:0008241]; tripeptidyl-peptidase activity [GO:0008240]; zinc ion binding [GO:0008270]; amyloid-beta metabolic process [GO:0050435]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; angiotensin maturation [GO:0002003]; animal organ regeneration [GO:0031100]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; arachidonic acid secretion [GO:0050482]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; bradykinin catabolic process [GO:0010815]; cell proliferation in bone marrow [GO:0071838]; cellular response to aldosterone [GO:1904045]; cellular response to glucose stimulus [GO:0071333]; eating behavior [GO:0042755]; embryo development ending in birth or egg hatching [GO:0009792]; female pregnancy [GO:0007565]; heart contraction [GO:0060047]; hematopoietic stem cell differentiation [GO:0060218]; hormone catabolic process [GO:0042447]; hormone metabolic process [GO:0042445]; kidney development [GO:0001822]; lung alveolus development [GO:0048286]; male gonad development [GO:0008584]; mononuclear cell proliferation [GO:0032943]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gap junction assembly [GO:1903597]; negative regulation of gene expression [GO:0010629]; negative regulation of glucose import [GO:0046325]; neutrophil mediated immunity [GO:0002446]; peptide catabolic process [GO:0043171]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neurogenesis [GO:0050769]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; post-transcriptional regulation of gene expression [GO:0010608]; proteolysis [GO:0006508]; regulation of angiotensin metabolic process [GO:0060177]; regulation of blood pressure [GO:0008217]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of renal output by angiotensin [GO:0002019]; regulation of smooth muscle cell migration [GO:0014910]; regulation of synaptic plasticity [GO:0048167]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; regulation of vasoconstriction [GO:0019229]; response to dexamethasone [GO:0071548]; response to hypoxia [GO:0001666]; response to laminar fluid shear stress [GO:0034616]; response to lipopolysaccharide [GO:0032496]; response to nutrient levels [GO:0031667]; response to thyroid hormone [GO:0097066]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]; substance P catabolic process [GO:0010814]; vasoconstriction [GO:0042310]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12386153}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P09470}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250|UniProtKB:P09470}.; SUBCELLULAR LOCATION: [Angiotensin-converting enzyme, soluble form]: Secreted {ECO:0000269|PubMed:10769174, ECO:0000269|PubMed:11274151, ECO:0000269|PubMed:7499427, ECO:0000269|PubMed:8253769}.; SUBCELLULAR LOCATION: [Isoform Testis-specific]: Cell membrane {ECO:0000269|PubMed:1668266, ECO:0000269|PubMed:8626443}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:1668266}. Note=The testis-specific isoform can be cleaved before the transmembrane region, releasing a soluble form. {ECO:0000269|PubMed:1668266}.
P12829	reviewed	MYL4_HUMAN	Myosin light chain 4 (Myosin light chain 1, embryonic muscle/atrial isoform) (Myosin light chain alkali GT-1 isoform)	MYL4 MLC1 PRO1957	Homo sapiens (Human)	197	FUNCTION: Regulatory light chain of myosin. Does not bind calcium.		cardiac muscle contraction [GO:0060048]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of the force of heart contraction [GO:0002026]	A band [GO:0031672]; cytosol [GO:0005829]; myosin II complex [GO:0016460]	actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; calcium ion binding [GO:0005509]; myosin II heavy chain binding [GO:0032038]	A band [GO:0031672]; cytosol [GO:0005829]; myosin II complex [GO:0016460]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; calcium ion binding [GO:0005509]; myosin II heavy chain binding [GO:0032038]; cardiac muscle contraction [GO:0060048]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of the force of heart contraction [GO:0002026]	
P12830	reviewed	CADH1_HUMAN	Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]	CDH1 CDHE UVO	Homo sapiens (Human)	882	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cellular response to indole-3-methanol [GO:0071681]; cellular response to lithium ion [GO:0071285]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of axon extension [GO:0030517]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-cell adhesion [GO:0022408]; neuron projection development [GO:0031175]; pituitary gland development [GO:0021983]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; protein localization to plasma membrane [GO:0072659]; regulation of gene expression [GO:0010468]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; response to Gram-positive bacterium [GO:0140459]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cytoplasmic side of plasma membrane [GO:0009898]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; flotillin complex [GO:0016600]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; trans-Golgi network [GO:0005802]	ankyrin binding [GO:0030506]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; gamma-catenin binding [GO:0045295]; GTPase activating protein binding [GO:0032794]; identical protein binding [GO:0042802]; protein tyrosine kinase binding [GO:1990782]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cytoplasmic side of plasma membrane [GO:0009898]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; flotillin complex [GO:0016600]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; trans-Golgi network [GO:0005802]; ankyrin binding [GO:0030506]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; gamma-catenin binding [GO:0045295]; GTPase activating protein binding [GO:0032794]; identical protein binding [GO:0042802]; protein tyrosine kinase binding [GO:1990782]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cellular response to indole-3-methanol [GO:0071681]; cellular response to lithium ion [GO:0071285]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of axon extension [GO:0030517]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-cell adhesion [GO:0022408]; neuron projection development [GO:0031175]; pituitary gland development [GO:0021983]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; protein localization to plasma membrane [GO:0072659]; regulation of gene expression [GO:0010468]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; response to Gram-positive bacterium [GO:0140459]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:28169360}. Cell membrane {ECO:0000269|PubMed:19403558, ECO:0000269|PubMed:28301459}; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
P12838	reviewed	DEF4_HUMAN	Defensin alpha 4 (Corticostatin HP-4) (HNP-4) (HP-4) (Neutrophil defensin 4)	DEFA4 DEF4	Homo sapiens (Human)	97	FUNCTION: Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi (PubMed:2500436, PubMed:2501794, PubMed:15317502, PubMed:15616305, PubMed:30658057). Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro) (PubMed:2500436, PubMed:2501794, PubMed:15317502, PubMed:15616305, PubMed:17088326, PubMed:30658057). Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B.anthracis anthrax lethal factor lef (PubMed:15620707, PubMed:30658057). Protects blood cells against infection with HIV-1 (in vitro) (PubMed:15620707). Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro) (PubMed:30658057). Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro) (PubMed:2843187). {ECO:0000269|PubMed:15317502, ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:15620707, ECO:0000269|PubMed:17088326, ECO:0000269|PubMed:2500436, ECO:0000269|PubMed:2501794, ECO:0000269|PubMed:2843187, ECO:0000269|PubMed:30658057}.		antibacterial humoral response [GO:0019731]; antifungal humoral response [GO:0019732]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; antimicrobial humoral response [GO:0019730]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; killing of cells of another organism [GO:0031640]; perturbation of plasma membrane integrity in another organism [GO:0051673]	azurophil granule [GO:0042582]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; specific granule lumen [GO:0035580]; transport vesicle [GO:0030133]	protein homodimerization activity [GO:0042803]	azurophil granule [GO:0042582]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; specific granule lumen [GO:0035580]; transport vesicle [GO:0030133]; protein homodimerization activity [GO:0042803]; antibacterial humoral response [GO:0019731]; antifungal humoral response [GO:0019732]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; antimicrobial humoral response [GO:0019730]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; killing of cells of another organism [GO:0031640]; perturbation of plasma membrane integrity in another organism [GO:0051673]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q01523}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:2500436, ECO:0000269|PubMed:2501794}. Note=Stored as mature peptide in neutrophil granules. {ECO:0000269|PubMed:2500436}.
P12882	reviewed	MYH1_HUMAN	Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1)	MYH1	Homo sapiens (Human)	1939	FUNCTION: Muscle contraction.		muscle contraction [GO:0006936]	A band [GO:0031672]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; intercalated disc [GO:0014704]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]	A band [GO:0031672]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; intercalated disc [GO:0014704]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; muscle contraction [GO:0006936]	SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
P12883	reviewed	MYH7_HUMAN	Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)	MYH7 MYHCB	Homo sapiens (Human)	1935	FUNCTION: Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.	MISCELLANEOUS: The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.	adult heart development [GO:0007512]; ATP metabolic process [GO:0046034]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy in response to stress [GO:0014898]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; regulation of heart rate [GO:0002027]; regulation of slow-twitch skeletal muscle fiber contraction [GO:0031449]; regulation of the force of heart contraction [GO:0002026]; regulation of the force of skeletal muscle contraction [GO:0014728]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]; striated muscle contraction [GO:0006941]; transition between fast and slow fiber [GO:0014883]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	cytoplasm [GO:0005737]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin complex [GO:0016459]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]	cytoplasm [GO:0005737]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin complex [GO:0016459]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; adult heart development [GO:0007512]; ATP metabolic process [GO:0046034]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy in response to stress [GO:0014898]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; regulation of heart rate [GO:0002027]; regulation of slow-twitch skeletal muscle fiber contraction [GO:0031449]; regulation of the force of heart contraction [GO:0002026]; regulation of the force of skeletal muscle contraction [GO:0014728]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]; striated muscle contraction [GO:0006941]; transition between fast and slow fiber [GO:0014883]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	SUBCELLULAR LOCATION: Cytoplasm, myofibril {ECO:0000250|UniProtKB:P02564}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:P02564}. Note=Thick filaments of the myofibrils. {ECO:0000250|UniProtKB:P02564}.
P12931	reviewed	SRC_HUMAN	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)	SRC SRC1	Homo sapiens (Human)	536	FUNCTION: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.		adherens junction organization [GO:0034332]; angiotensin-activated signaling pathway involved in heart process [GO:0086098]; bone resorption [GO:0045453]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cell-cell adhesion [GO:0098609]; cellular response to fatty acid [GO:0071398]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to progesterone stimulus [GO:0071393]; cellular response to prolactin [GO:1990646]; DNA biosynthetic process [GO:0071897]; entry of bacterium into host cell [GO:0035635]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2 signaling pathway [GO:0038128]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; focal adhesion assembly [GO:0048041]; forebrain development [GO:0030900]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; intracellular signal transduction [GO:0035556]; learning or memory [GO:0007611]; leukocyte migration [GO:0050900]; macroautophagy [GO:0016236]; myoblast proliferation [GO:0051450]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; neurotrophin TRK receptor signaling pathway [GO:0048011]; odontogenesis [GO:0042476]; oogenesis [GO:0048477]; osteoclast development [GO:0036035]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cytokine production [GO:0001819]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of hippo signaling [GO:0035332]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of integrin activation [GO:0033625]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of male germ cell proliferation [GO:2000256]; positive regulation of non-membrane spanning protein tyrosine kinase activity [GO:1903997]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein processing [GO:0010954]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein transport [GO:0051222]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; primary ovarian follicle growth [GO:0001545]; progesterone receptor signaling pathway [GO:0050847]; protein autophosphorylation [GO:0046777]; protein destabilization [GO:0031648]; regulation of bone resorption [GO:0045124]; regulation of caveolin-mediated endocytosis [GO:2001286]; regulation of cell projection assembly [GO:0060491]; regulation of cell-cell adhesion [GO:0022407]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of epithelial cell migration [GO:0010632]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of toll-like receptor 3 signaling pathway [GO:0034139]; regulation of vascular permeability [GO:0043114]; response to acidic pH [GO:0010447]; response to electrical stimulus [GO:0051602]; response to interleukin-1 [GO:0070555]; response to mechanical stimulus [GO:0009612]; response to mineralocorticoid [GO:0051385]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; skeletal muscle cell proliferation [GO:0014856]; spermatogenesis [GO:0007283]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress fiber assembly [GO:0043149]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell costimulation [GO:0031295]; transcytosis [GO:0045056]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	actin filament [GO:0005884]; caveola [GO:0005901]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic filopodium [GO:1902737]; dendritic growth cone [GO:0044294]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic specialization, intracellular component [GO:0099091]; ruffle membrane [GO:0032587]; synaptic membrane [GO:0097060]	ATP binding [GO:0005524]; ATPase binding [GO:0051117]; BMP receptor binding [GO:0070700]; cadherin binding [GO:0045296]; connexin binding [GO:0071253]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; heme binding [GO:0020037]; insulin receptor binding [GO:0005158]; integrin binding [GO:0005178]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; nuclear estrogen receptor binding [GO:0030331]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]	actin filament [GO:0005884]; caveola [GO:0005901]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic filopodium [GO:1902737]; dendritic growth cone [GO:0044294]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic specialization, intracellular component [GO:0099091]; ruffle membrane [GO:0032587]; synaptic membrane [GO:0097060]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; BMP receptor binding [GO:0070700]; cadherin binding [GO:0045296]; connexin binding [GO:0071253]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; heme binding [GO:0020037]; insulin receptor binding [GO:0005158]; integrin binding [GO:0005178]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; nuclear estrogen receptor binding [GO:0030331]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; adherens junction organization [GO:0034332]; angiotensin-activated signaling pathway involved in heart process [GO:0086098]; bone resorption [GO:0045453]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cell-cell adhesion [GO:0098609]; cellular response to fatty acid [GO:0071398]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to progesterone stimulus [GO:0071393]; cellular response to prolactin [GO:1990646]; DNA biosynthetic process [GO:0071897]; entry of bacterium into host cell [GO:0035635]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2 signaling pathway [GO:0038128]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; focal adhesion assembly [GO:0048041]; forebrain development [GO:0030900]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; intracellular signal transduction [GO:0035556]; learning or memory [GO:0007611]; leukocyte migration [GO:0050900]; macroautophagy [GO:0016236]; myoblast proliferation [GO:0051450]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; neurotrophin TRK receptor signaling pathway [GO:0048011]; odontogenesis [GO:0042476]; oogenesis [GO:0048477]; osteoclast development [GO:0036035]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cytokine production [GO:0001819]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of hippo signaling [GO:0035332]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of integrin activation [GO:0033625]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of male germ cell proliferation [GO:2000256]; positive regulation of non-membrane spanning protein tyrosine kinase activity [GO:1903997]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein processing [GO:0010954]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein transport [GO:0051222]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; primary ovarian follicle growth [GO:0001545]; progesterone receptor signaling pathway [GO:0050847]; protein autophosphorylation [GO:0046777]; protein destabilization [GO:0031648]; regulation of bone resorption [GO:0045124]; regulation of caveolin-mediated endocytosis [GO:2001286]; regulation of cell projection assembly [GO:0060491]; regulation of cell-cell adhesion [GO:0022407]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of epithelial cell migration [GO:0010632]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of toll-like receptor 3 signaling pathway [GO:0034139]; regulation of vascular permeability [GO:0043114]; response to acidic pH [GO:0010447]; response to electrical stimulus [GO:0051602]; response to interleukin-1 [GO:0070555]; response to mechanical stimulus [GO:0009612]; response to mineralocorticoid [GO:0051385]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; skeletal muscle cell proliferation [GO:0014856]; spermatogenesis [GO:0007283]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress fiber assembly [GO:0043149]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell costimulation [GO:0031295]; transcytosis [GO:0045056]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7525268}; Lipid-anchor {ECO:0000269|PubMed:22801373}. Mitochondrion inner membrane {ECO:0000269|PubMed:12615910}. Nucleus {ECO:0000269|PubMed:7853507}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7525268}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19307596}. Cell junction, focal adhesion {ECO:0000269|PubMed:22801373}. Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268). Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596). {ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:22801373, ECO:0000269|PubMed:7525268}.
P12955	reviewed	PEPD_HUMAN	Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase)	PEPD PRD	Homo sapiens (Human)	493	FUNCTION: Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position (PubMed:17081196, PubMed:35165443). The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved (PubMed:17081196). Plays an important role in collagen metabolism because the high level of iminoacids in collagen (PubMed:2925654). {ECO:0000269|PubMed:17081196, ECO:0000269|PubMed:2925654, ECO:0000269|PubMed:35165443}.		amino acid metabolic process [GO:0006520]; collagen catabolic process [GO:0030574]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]	manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metallocarboxypeptidase activity [GO:0004181]; peptidase activity [GO:0008233]; proline dipeptidase activity [GO:0102009]	extracellular exosome [GO:0070062]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metallocarboxypeptidase activity [GO:0004181]; peptidase activity [GO:0008233]; proline dipeptidase activity [GO:0102009]; amino acid metabolic process [GO:0006520]; collagen catabolic process [GO:0030574]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]	
P12956	reviewed	XRCC6_HUMAN	X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)	XRCC6 G22P1	Homo sapiens (Human)	609	FUNCTION: Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912, PubMed:20493174, PubMed:2466842, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912, PubMed:20493174, PubMed:2466842, PubMed:9742108). Also has a role in chromosome translocation (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912, PubMed:20493174, PubMed:2466842, PubMed:9742108). Has a role in chromosome translocation (PubMed:7957065, PubMed:20493174, PubMed:2466842, PubMed:9742108, PubMed:8621488, PubMed:12145306, PubMed:11493912). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:7957065, PubMed:8621488, PubMed:20493174, PubMed:2466842, PubMed:9742108, PubMed:12145306, PubMed:11493912). It works in the 3'-5' direction (PubMed:20493174, PubMed:2466842, PubMed:9742108, PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:7957065, PubMed:8621488, PubMed:20493174, PubMed:2466842, PubMed:9742108, PubMed:12145306, PubMed:11493912). Binding to DNA may be mediated by XRCC6 (PubMed:20493174, PubMed:2466842, PubMed:9742108, PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912). The XRCC5-XRRC6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912, PubMed:20493174, PubMed:2466842, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912, PubMed:20493174, PubMed:2466842, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912, PubMed:20493174, PubMed:2466842, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}.	MISCELLANEOUS: Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to XRCC5 and XRCC6. Existence of a major autoantigenic epitope or epitopes on the C-terminal 190 amino acids of XRCC6 containing the leucine repeat. The majority of autoantibodies to XRCC6 in most sera from patients with SLE seem to be reactive with this region.	activation of innate immune response [GO:0002218]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to gamma radiation [GO:0071480]; cellular response to X-ray [GO:0071481]; DNA ligation [GO:0006266]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of transcription by RNA polymerase II [GO:0045944]; recombinational repair [GO:0000725]; regulation of smooth muscle cell proliferation [GO:0048660]; telomere maintenance [GO:0000723]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; secretory granule lumen [GO:0034774]; transcription regulator complex [GO:0005667]	5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; cyclin binding [GO:0030332]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; double-stranded DNA binding [GO:0003690]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; telomeric DNA binding [GO:0042162]; transcription cis-regulatory region binding [GO:0000976]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; secretory granule lumen [GO:0034774]; transcription regulator complex [GO:0005667]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; cyclin binding [GO:0030332]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; double-stranded DNA binding [GO:0003690]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; telomeric DNA binding [GO:0042162]; transcription cis-regulatory region binding [GO:0000976]; activation of innate immune response [GO:0002218]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to gamma radiation [GO:0071480]; cellular response to X-ray [GO:0071481]; DNA ligation [GO:0006266]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of transcription by RNA polymerase II [GO:0045944]; recombinational repair [GO:0000725]; regulation of smooth muscle cell proliferation [GO:0048660]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22442688}. Chromosome {ECO:0000269|PubMed:22442688}.
P12980	reviewed	LYL1_HUMAN	Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1)	LYL1 BHLHA18	Homo sapiens (Human)	280			B cell differentiation [GO:0030183]; blood vessel maturation [GO:0001955]; definitive hemopoiesis [GO:0060216]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; B cell differentiation [GO:0030183]; blood vessel maturation [GO:0001955]; definitive hemopoiesis [GO:0060216]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
P13010	reviewed	XRCC5_HUMAN	X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))	XRCC5 G22P2	Homo sapiens (Human)	732	FUNCTION: Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912). Required for double-strand break repair and V(D)J recombination (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912). Also has a role in chromosome translocation (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912). It works in the 3'-5' direction (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912). Binding to DNA may be mediated by XRCC6 (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912). The XRCC5-XRRC6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:20383123, PubMed:11493912). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:20383123). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:20383123). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}.	MISCELLANEOUS: Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to XRCC6 and XRCC5. {ECO:0000269|PubMed:7957065}.	activation of innate immune response [GO:0002218]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to fatty acid [GO:0071398]; cellular response to gamma radiation [GO:0071480]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to X-ray [GO:0071481]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell proliferation [GO:0071425]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of t-circle formation [GO:1904430]; neurogenesis [GO:0022008]; positive regulation of catalytic activity [GO:0043085]; positive regulation of neurogenesis [GO:0050769]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein localization to chromosome, telomeric region [GO:0070198]; recombinational repair [GO:0000725]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of telomere maintenance [GO:0032204]; response to xenobiotic stimulus [GO:0009410]; small-subunit processome assembly [GO:0034462]; telomere maintenance [GO:0000723]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; extracellular region [GO:0005576]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]; site of DNA damage [GO:0090734]; small-subunit processome [GO:0032040]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA end binding [GO:0045027]; DNA helicase activity [GO:0003678]; double-stranded DNA binding [GO:0003690]; enzyme activator activity [GO:0008047]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]; transcription cis-regulatory region binding [GO:0000976]; U3 snoRNA binding [GO:0034511]; ubiquitin protein ligase binding [GO:0031625]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; extracellular region [GO:0005576]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]; site of DNA damage [GO:0090734]; small-subunit processome [GO:0032040]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA end binding [GO:0045027]; DNA helicase activity [GO:0003678]; double-stranded DNA binding [GO:0003690]; enzyme activator activity [GO:0008047]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]; transcription cis-regulatory region binding [GO:0000976]; U3 snoRNA binding [GO:0034511]; ubiquitin protein ligase binding [GO:0031625]; activation of innate immune response [GO:0002218]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to fatty acid [GO:0071398]; cellular response to gamma radiation [GO:0071480]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to X-ray [GO:0071481]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell proliferation [GO:0071425]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of t-circle formation [GO:1904430]; neurogenesis [GO:0022008]; positive regulation of catalytic activity [GO:0043085]; positive regulation of neurogenesis [GO:0050769]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein localization to chromosome, telomeric region [GO:0070198]; recombinational repair [GO:0000725]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of telomere maintenance [GO:0032204]; response to xenobiotic stimulus [GO:0009410]; small-subunit processome assembly [GO:0034462]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22442688, ECO:0000269|PubMed:32103174}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:32103174}. Chromosome {ECO:0000269|PubMed:22442688}.
P13051	reviewed	UNG_HUMAN	Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)	UNG DGU UNG1 UNG15	Homo sapiens (Human)	313	FUNCTION: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.		base-excision repair [GO:0006284]; base-excision repair, AP site formation via deaminated base removal [GO:0097510]; depyrimidination [GO:0045008]; DNA repair [GO:0006281]; isotype switching [GO:0045190]; negative regulation of apoptotic process [GO:0043066]; somatic hypermutation of immunoglobulin genes [GO:0016446]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	damaged DNA binding [GO:0003684]; ribosomal small subunit binding [GO:0043024]; uracil DNA N-glycosylase activity [GO:0004844]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; damaged DNA binding [GO:0003684]; ribosomal small subunit binding [GO:0043024]; uracil DNA N-glycosylase activity [GO:0004844]; base-excision repair [GO:0006284]; base-excision repair, AP site formation via deaminated base removal [GO:0097510]; depyrimidination [GO:0045008]; DNA repair [GO:0006281]; isotype switching [GO:0045190]; negative regulation of apoptotic process [GO:0043066]; somatic hypermutation of immunoglobulin genes [GO:0016446]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
P13056	reviewed	NR2C1_HUMAN	Nuclear receptor subfamily 2 group C member 1 (Orphan nuclear receptor TR2) (Testicular receptor 2)	NR2C1 TR2	Homo sapiens (Human)	603	FUNCTION: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. {ECO:0000269|PubMed:12093804, ECO:0000269|PubMed:17010934}.		anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; PML body [GO:0016605]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor activity [GO:0038023]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; PML body [GO:0016605]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor activity [GO:0038023]; zinc ion binding [GO:0008270]; anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Nucleus, PML body {ECO:0000250}. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation. {ECO:0000250}.
P13073	reviewed	COX41_HUMAN	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)	COX4I1 COX4	Homo sapiens (Human)	169	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}.		cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	cytochrome-c oxidase activity [GO:0004129]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; cytochrome-c oxidase activity [GO:0004129]; cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
P13164	reviewed	IFM1_HUMAN	Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Interferon-induced protein 17) (Interferon-inducible protein 9-27) (Leu-13 antigen) (CD antigen CD225)	IFITM1 CD225 IFI17	Homo sapiens (Human)	125	FUNCTION: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Inhibits SARS-CoV-2 S protein-mediated syncytia formation (PubMed:33051876). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:22634173, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:33270927}.		cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral genome replication [GO:0045071]; ossification [GO:0001503]; positive regulation of osteoblast differentiation [GO:0045669]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]		lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral genome replication [GO:0045071]; ossification [GO:0001503]; positive regulation of osteoblast differentiation [GO:0045669]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:19499152, ECO:0000269|PubMed:25105503, ECO:0000269|PubMed:26354436}; Single-pass membrane protein {ECO:0000269|PubMed:19499152}. Lysosome membrane {ECO:0000269|PubMed:26354436}.
P13196	reviewed	HEM1_HUMAN	5-aminolevulinate synthase, non-specific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1)	ALAS1 ALAS3 ALASH OK/SW-cl.121	Homo sapiens (Human)	640	FUNCTION: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. {ECO:0000269|PubMed:16234850, ECO:0000269|PubMed:17975826}.		erythrocyte development [GO:0048821]; heme biosynthetic process [GO:0006783]; hemoglobin biosynthetic process [GO:0042541]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to bile acid [GO:1903412]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	5-aminolevulinate synthase activity [GO:0003870]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; 5-aminolevulinate synthase activity [GO:0003870]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; erythrocyte development [GO:0048821]; heme biosynthetic process [GO:0006783]; hemoglobin biosynthetic process [GO:0042541]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to bile acid [GO:1903412]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P22557}; Peripheral membrane protein {ECO:0000250|UniProtKB:P22557}. Note=Localizes to the matrix side of the mitochondrion inner membrane. {ECO:0000250|UniProtKB:P22557}.
P13224	reviewed	GP1BB_HUMAN	Platelet glycoprotein Ib beta chain (GP-Ib beta) (GPIb-beta) (GPIbB) (Antigen CD42b-beta) (CD antigen CD42c)	GP1BB	Homo sapiens (Human)	206	FUNCTION: Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.	MISCELLANEOUS: Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.	blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; megakaryocyte development [GO:0035855]; platelet activation [GO:0030168]; positive regulation of platelet activation [GO:0010572]; release of sequestered calcium ion into cytosol [GO:0051209]	glycoprotein Ib-IX-V complex [GO:1990779]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]	glycoprotein Ib-IX-V complex [GO:1990779]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]; blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; megakaryocyte development [GO:0035855]; platelet activation [GO:0030168]; positive regulation of platelet activation [GO:0010572]; release of sequestered calcium ion into cytosol [GO:0051209]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P13232	reviewed	IL7_HUMAN	Interleukin-7 (IL-7)	IL7	Homo sapiens (Human)	177	FUNCTION: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis (PubMed:7527823, PubMed:25870237). Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG (PubMed:8128231). Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5 (PubMed:18523275, PubMed:20974963). {ECO:0000269|PubMed:18523275, ECO:0000269|PubMed:20974963, ECO:0000269|PubMed:25870237, ECO:0000269|PubMed:7527823, ECO:0000269|PubMed:8128231}.		animal organ morphogenesis [GO:0009887]; B cell proliferation [GO:0042100]; bone resorption [GO:0045453]; cell-cell signaling [GO:0007267]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; organ growth [GO:0035265]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of organ growth [GO:0046622]; positive regulation of T cell differentiation [GO:0045582]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; T cell lineage commitment [GO:0002360]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-7 receptor binding [GO:0005139]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-7 receptor binding [GO:0005139]; animal organ morphogenesis [GO:0009887]; B cell proliferation [GO:0042100]; bone resorption [GO:0045453]; cell-cell signaling [GO:0007267]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; organ growth [GO:0035265]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of organ growth [GO:0046622]; positive regulation of T cell differentiation [GO:0045582]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; T cell lineage commitment [GO:0002360]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25870237}.
P13236	reviewed	CCL4_HUMAN	C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]	CCL4 LAG1 MIP1B SCYA4	Homo sapiens (Human)	92	FUNCTION: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}.		cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; establishment or maintenance of cell polarity [GO:0007163]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; negative regulation by host of viral transcription [GO:0043922]; neutrophil chemotaxis [GO:0030593]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of natural killer cell chemotaxis [GO:2000503]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR1 chemokine receptor binding [GO:0031726]; CCR5 chemokine receptor binding [GO:0031730]; chemokine activity [GO:0008009]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR1 chemokine receptor binding [GO:0031726]; CCR5 chemokine receptor binding [GO:0031730]; chemokine activity [GO:0008009]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; establishment or maintenance of cell polarity [GO:0007163]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; negative regulation by host of viral transcription [GO:0043922]; neutrophil chemotaxis [GO:0030593]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of natural killer cell chemotaxis [GO:2000503]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P13284	reviewed	GILT_HUMAN	Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.-.-) (Gamma-interferon-inducible protein IP-30) (Legumaturain)	IFI30 GILT IP30	Homo sapiens (Human)	250	FUNCTION: Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). {ECO:0000250}.	MISCELLANEOUS: Both precursor form and mature form have thiol reductase activity.	antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; negative regulation of fibroblast proliferation [GO:0048147]; protein stabilization [GO:0050821]	cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	oxidoreductase activity, acting on a sulfur group of donors [GO:0016667]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]	cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; oxidoreductase activity, acting on a sulfur group of donors [GO:0016667]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; negative regulation of fibroblast proliferation [GO:0048147]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10639150, ECO:0000269|PubMed:3136170}. Lysosome {ECO:0000269|PubMed:10639150, ECO:0000269|PubMed:3136170}.
P13349	reviewed	MYF5_HUMAN	Myogenic factor 5 (Myf-5) (Class C basic helix-loop-helix protein 2) (bHLHc2)	MYF5 BHLHC2	Homo sapiens (Human)	255	FUNCTION: Transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation (PubMed:29887215). Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. {ECO:0000269|PubMed:2721498, ECO:0000269|PubMed:29887215}.		camera-type eye development [GO:0043010]; cartilage condensation [GO:0001502]; embryonic skeletal system morphogenesis [GO:0048704]; extracellular matrix organization [GO:0030198]; muscle cell fate commitment [GO:0042693]; muscle organ development [GO:0007517]; muscle tissue morphogenesis [GO:0060415]; ossification [GO:0001503]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of skeletal muscle fiber development [GO:0048743]; regulation of cell-matrix adhesion [GO:0001952]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; camera-type eye development [GO:0043010]; cartilage condensation [GO:0001502]; embryonic skeletal system morphogenesis [GO:0048704]; extracellular matrix organization [GO:0030198]; muscle cell fate commitment [GO:0042693]; muscle organ development [GO:0007517]; muscle tissue morphogenesis [GO:0060415]; ossification [GO:0001503]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of skeletal muscle fiber development [GO:0048743]; regulation of cell-matrix adhesion [GO:0001952]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29887215}.
P13378	reviewed	HXD8_HUMAN	Homeobox protein Hox-D8 (Homeobox protein Hox-4E) (Homeobox protein Hox-5.4)	HOXD8 HOX4E	Homo sapiens (Human)	290	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior axis specification, embryo [GO:0008595]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system morphogenesis [GO:0048705]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior axis specification, embryo [GO:0008595]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system morphogenesis [GO:0048705]	SUBCELLULAR LOCATION: Nucleus.
P13385	reviewed	TDGF1_HUMAN	Protein Cripto (Cripto, EGF-CFC family member) (Cripto-1 growth factor) (CRGF) (Epidermal growth factor-like cripto protein CR1) (Teratocarcinoma-derived growth factor 1)	CRIPTO CRIPTO-1 TDGF1	Homo sapiens (Human)	188	FUNCTION: GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953). {ECO:0000269|PubMed:11909953, ECO:0000269|PubMed:27881714}.		anterior/posterior axis specification, embryo [GO:0008595]; anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; cell differentiation [GO:0030154]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to interleukin-6 [GO:0071354]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; determination of left/right symmetry [GO:0007368]; embryo development ending in birth or egg hatching [GO:0009792]; heart development [GO:0007507]; mammary gland development [GO:0030879]; morphogenesis of a branching structure [GO:0001763]; negative regulation of apoptotic process [GO:0043066]; nodal signaling pathway [GO:0038092]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of signal transduction [GO:0009966]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extrinsic component of plasma membrane [GO:0019897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	activin receptor binding [GO:0070697]; growth factor activity [GO:0008083]; nodal binding [GO:0038100]; signaling receptor binding [GO:0005102]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extrinsic component of plasma membrane [GO:0019897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; activin receptor binding [GO:0070697]; growth factor activity [GO:0008083]; nodal binding [GO:0038100]; signaling receptor binding [GO:0005102]; anterior/posterior axis specification, embryo [GO:0008595]; anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; cell differentiation [GO:0030154]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to interleukin-6 [GO:0071354]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; determination of left/right symmetry [GO:0007368]; embryo development ending in birth or egg hatching [GO:0009792]; heart development [GO:0007507]; mammary gland development [GO:0030879]; morphogenesis of a branching structure [GO:0001763]; negative regulation of apoptotic process [GO:0043066]; nodal signaling pathway [GO:0038092]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18930707, ECO:0000269|PubMed:27881714}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18930707, ECO:0000269|PubMed:27881714}. Secreted {ECO:0000269|PubMed:27881714}. Note=Released from the cell membrane by GPI cleavage. {ECO:0000269|PubMed:27881714}.
P13473	reviewed	LAMP2_HUMAN	Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b)	LAMP2	Homo sapiens (Human)	410	FUNCTION: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032, PubMed:36586411, PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032, PubMed:36586411). Functions by binding target proteins, such as GAPDH, NLRP3 and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:36586411). In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 (PubMed:36586411). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820). {ECO:0000250|UniProtKB:P17046, ECO:0000269|PubMed:11082038, ECO:0000269|PubMed:18644871, ECO:0000269|PubMed:20518820, ECO:0000269|PubMed:24880125, ECO:0000269|PubMed:27628032, ECO:0000269|PubMed:36586411, ECO:0000269|PubMed:37390818, ECO:0000269|PubMed:8662539}.; FUNCTION: [Isoform LAMP-2C]: Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII. {ECO:0000269|PubMed:26856698}.; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. {ECO:0000269|PubMed:32295904}.		autophagosome maturation [GO:0097352]; cellular response to starvation [GO:0009267]; chaperone-mediated autophagy [GO:0061684]; lysosomal protein catabolic process [GO:1905146]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of protein-containing complex assembly [GO:0031333]; protein catabolic process [GO:0030163]; protein import [GO:0017038]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740]; regulation of protein stability [GO:0031647]	autolysosome [GO:0044754]; autophagosome membrane [GO:0000421]; azurophil granule membrane [GO:0035577]; chaperone-mediated autophagy translocation complex [GO:0061742]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; trans-Golgi network [GO:0005802]	enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; signaling adaptor activity [GO:0035591]	autolysosome [GO:0044754]; autophagosome membrane [GO:0000421]; azurophil granule membrane [GO:0035577]; chaperone-mediated autophagy translocation complex [GO:0061742]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; trans-Golgi network [GO:0005802]; enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; signaling adaptor activity [GO:0035591]; autophagosome maturation [GO:0097352]; cellular response to starvation [GO:0009267]; chaperone-mediated autophagy [GO:0061684]; lysosomal protein catabolic process [GO:1905146]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of protein-containing complex assembly [GO:0031333]; protein catabolic process [GO:0030163]; protein import [GO:0017038]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:11082038, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:18644871, ECO:0000269|PubMed:2912382}; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Endosome membrane {ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Cell membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:2912382}; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:P17047}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. {ECO:0000269|PubMed:17897319}.
P13489	reviewed	RINI_HUMAN	Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI)	RNH1 PRI RNH	Homo sapiens (Human)	461	FUNCTION: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218, ECO:0000269|PubMed:17292889}.		cell migration [GO:0016477]; mRNA catabolic process [GO:0006402]; regulation of angiogenesis [GO:0045765]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]	angiogenin-PRI complex [GO:0032311]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ribonuclease inhibitor activity [GO:0008428]	angiogenin-PRI complex [GO:0032311]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ribonuclease inhibitor activity [GO:0008428]; cell migration [GO:0016477]; mRNA catabolic process [GO:0006402]; regulation of angiogenesis [GO:0045765]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]	SUBCELLULAR LOCATION: Cytoplasm.
P13497	reviewed	BMP1_HUMAN	Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP)	BMP1 PCOLC	Homo sapiens (Human)	986	FUNCTION: Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546). Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:33169406, PubMed:32636307). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers (PubMed:31152061, PubMed:33206546). Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307). {ECO:0000269|PubMed:31152061, ECO:0000269|PubMed:32636307, ECO:0000269|PubMed:33169406, ECO:0000269|PubMed:33206546}.; FUNCTION: [Isoform BMP1-3]: Plays an important role in bone repair by acting as a coactivator of BMP7. {ECO:0000269|PubMed:21453682}.	MISCELLANEOUS: [Isoform BMP1-4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform BMP1-5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform BMP1-6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; ossification [GO:0001503]; positive regulation of cartilage development [GO:0061036]; protein processing [GO:0016485]; proteolysis [GO:0006508]; skeletal system development [GO:0001501]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; vesicle [GO:0031982]	calcium ion binding [GO:0005509]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; vesicle [GO:0031982]; calcium ion binding [GO:0005509]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; ossification [GO:0001503]; positive regulation of cartilage development [GO:0061036]; protein processing [GO:0016485]; proteolysis [GO:0006508]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:12637569}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12637569}. Secreted {ECO:0000269|PubMed:33206546}. Note=Co-localizes with POSTN in the Golgi. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform BMP1-3]: Secreted {ECO:0000269|PubMed:21453682}.
P13498	reviewed	CY24A_HUMAN	Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox)	CYBA	Homo sapiens (Human)	195	FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. {ECO:0000269|PubMed:15824103}.		cytochrome complex assembly [GO:0017004]; establishment of localization in cell [GO:0051649]; hydrogen peroxide biosynthetic process [GO:0050665]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mucus secretion [GO:0070254]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mucus secretion [GO:0070257]; positive regulation of phagocytosis [GO:0050766]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; respiratory burst [GO:0045730]; smooth muscle hypertrophy [GO:0014895]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; SH3 domain binding [GO:0017124]	endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; SH3 domain binding [GO:0017124]; cytochrome complex assembly [GO:0017004]; establishment of localization in cell [GO:0051649]; hydrogen peroxide biosynthetic process [GO:0050665]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mucus secretion [GO:0070254]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mucus secretion [GO:0070257]; positive regulation of phagocytosis [GO:0050766]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; respiratory burst [GO:0045730]; smooth muscle hypertrophy [GO:0014895]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15585859, ECO:0000269|PubMed:22808130}. Note=As unassembled monomer may localize to the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q61462}.
P13500	reviewed	CCL2_HUMAN	C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)	CCL2 MCP1 SCYA2	Homo sapiens (Human)	99	FUNCTION: Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690). {ECO:0000269|PubMed:10529171, ECO:0000269|PubMed:10587439, ECO:0000269|PubMed:8107690, ECO:0000269|PubMed:8195247, ECO:0000269|PubMed:8627182, ECO:0000269|PubMed:9792674, ECO:0000269|PubMed:9837883}.		angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; astrocyte cell migration [GO:0043615]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular homeostasis [GO:0019725]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; helper T cell extravasation [GO:0035684]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of natural killer cell chemotaxis [GO:2000502]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; neutrophil chemotaxis [GO:0030593]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of calcium ion import [GO:0090280]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of T cell activation [GO:0050870]; protein phosphorylation [GO:0006468]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell shape [GO:0008360]; response to bacterium [GO:0009617]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; viral genome replication [GO:0019079]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR2 chemokine receptor binding [GO:0031727]; chemokine activity [GO:0008009]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR2 chemokine receptor binding [GO:0031727]; chemokine activity [GO:0008009]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; astrocyte cell migration [GO:0043615]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular homeostasis [GO:0019725]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; helper T cell extravasation [GO:0035684]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of natural killer cell chemotaxis [GO:2000502]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; neutrophil chemotaxis [GO:0030593]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of calcium ion import [GO:0090280]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of T cell activation [GO:0050870]; protein phosphorylation [GO:0006468]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell shape [GO:0008360]; response to bacterium [GO:0009617]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; viral genome replication [GO:0019079]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:2513477}.
P13501	reviewed	CCL5_HUMAN	C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]	CCL5 D17S136E SCYA5	Homo sapiens (Human)	91	FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485). {ECO:0000269|PubMed:1380064, ECO:0000269|PubMed:15923218, ECO:0000269|PubMed:16791620, ECO:0000269|PubMed:17001303, ECO:0000269|PubMed:23979485, ECO:0000269|PubMed:8525373, ECO:0000269|PubMed:9516414}.		activation of phospholipase D activity [GO:0031584]; calcium ion transport [GO:0006816]; cell-cell signaling [GO:0007267]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cellular response to virus [GO:0098586]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; eosinophil chemotaxis [GO:0048245]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; leukocyte cell-cell adhesion [GO:0007159]; lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of viral genome replication [GO:0045071]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cellular biosynthetic process [GO:0031328]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of innate immune response [GO:0045089]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of natural killer cell chemotaxis [GO:2000503]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell apoptotic process [GO:0070234]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of translational initiation [GO:0045948]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of viral genome replication [GO:0045070]; regulation of chronic inflammatory response [GO:0002676]; regulation of insulin secretion [GO:0050796]; regulation of T cell activation [GO:0050863]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR1 chemokine receptor binding [GO:0031726]; CCR4 chemokine receptor binding [GO:0031729]; CCR5 chemokine receptor binding [GO:0031730]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; chemokine receptor antagonist activity [GO:0046817]; chemokine receptor binding [GO:0042379]; identical protein binding [GO:0042802]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase activator activity [GO:0016004]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein self-association [GO:0043621]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR1 chemokine receptor binding [GO:0031726]; CCR4 chemokine receptor binding [GO:0031729]; CCR5 chemokine receptor binding [GO:0031730]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; chemokine receptor antagonist activity [GO:0046817]; chemokine receptor binding [GO:0042379]; identical protein binding [GO:0042802]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase activator activity [GO:0016004]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein self-association [GO:0043621]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; activation of phospholipase D activity [GO:0031584]; calcium ion transport [GO:0006816]; cell-cell signaling [GO:0007267]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cellular response to virus [GO:0098586]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; eosinophil chemotaxis [GO:0048245]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; leukocyte cell-cell adhesion [GO:0007159]; lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of viral genome replication [GO:0045071]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cellular biosynthetic process [GO:0031328]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of innate immune response [GO:0045089]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of natural killer cell chemotaxis [GO:2000503]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell apoptotic process [GO:0070234]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of translational initiation [GO:0045948]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of viral genome replication [GO:0045070]; regulation of chronic inflammatory response [GO:0002676]; regulation of insulin secretion [GO:0050796]; regulation of T cell activation [GO:0050863]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Secreted.
P13521	reviewed	SCG2_HUMAN	Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin]	SCG2 CHGC	Homo sapiens (Human)	617	FUNCTION: Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {ECO:0000269|PubMed:19357184}.	MISCELLANEOUS: Binds calcium with a low-affinity.	angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]; eosinophil chemotaxis [GO:0048245]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell proliferation [GO:0001938]; protein secretion [GO:0009306]	endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; secretory granule [GO:0030141]	chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]	endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; secretory granule [GO:0030141]; chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]; eosinophil chemotaxis [GO:0048245]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell proliferation [GO:0001938]; protein secretion [GO:0009306]	SUBCELLULAR LOCATION: Secreted. Note=Neuroendocrine and endocrine secretory granules.
P13533	reviewed	MYH6_HUMAN	Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)	MYH6 MYHCA	Homo sapiens (Human)	1939	FUNCTION: Muscle contraction.	MISCELLANEOUS: The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.	adult heart development [GO:0007512]; ATP metabolic process [GO:0046034]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy in response to stress [GO:0014898]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; myofibril assembly [GO:0030239]; regulation of ATP-dependent activity [GO:0043462]; regulation of blood pressure [GO:0008217]; regulation of heart contraction [GO:0008016]; regulation of heart growth [GO:0060420]; regulation of heart rate [GO:0002027]; regulation of the force of heart contraction [GO:0002026]; sarcomere organization [GO:0045214]; striated muscle contraction [GO:0006941]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visceral muscle development [GO:0007522]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin complex [GO:0016459]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; myosin phosphatase activity [GO:0017018]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin complex [GO:0016459]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; myosin phosphatase activity [GO:0017018]; protein kinase binding [GO:0019901]; adult heart development [GO:0007512]; ATP metabolic process [GO:0046034]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy in response to stress [GO:0014898]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; myofibril assembly [GO:0030239]; regulation of ATP-dependent activity [GO:0043462]; regulation of blood pressure [GO:0008217]; regulation of heart contraction [GO:0008016]; regulation of heart growth [GO:0060420]; regulation of heart rate [GO:0002027]; regulation of the force of heart contraction [GO:0002026]; sarcomere organization [GO:0045214]; striated muscle contraction [GO:0006941]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visceral muscle development [GO:0007522]	SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
P13535	reviewed	MYH8_HUMAN	Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)	MYH8	Homo sapiens (Human)	1937	FUNCTION: Muscle contraction.		ATP metabolic process [GO:0046034]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle contraction [GO:0003009]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; myosin light chain binding [GO:0032027]; myosin phosphatase activity [GO:0017018]; structural constituent of muscle [GO:0008307]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; myosin light chain binding [GO:0032027]; myosin phosphatase activity [GO:0017018]; structural constituent of muscle [GO:0008307]; ATP metabolic process [GO:0046034]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle contraction [GO:0003009]	SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
P13569	reviewed	CFTR_HUMAN	Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)	CFTR ABCC7	Homo sapiens (Human)	1480	FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:15010471, PubMed:12588899, PubMed:17036051, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:1712898, PubMed:8910473, PubMed:9804160, PubMed:12529365, PubMed:17182731, PubMed:26846474, PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17434346, PubMed:27941075, PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}.	MISCELLANEOUS: [Isoform 2]: Exon 9 splicing depends upon 2 polymorphic tracts within intron 8, a T(n) tract and TG(n) tract, where the number of T and/or TG repeats affect the extent of correct splicing of exon 9. Low numbers of T residues and high numbers of TG repeats give rise to less efficient splicing. Transcripts that lack exon 9 sequences fail to mature. Causes congenital bilateral absence of the vas deferens (CBAVD). {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Alternative acceptor site favored by mutation in an exonic splicing enhancer (ESE). Causes cystic fibrosis (CF). {ECO:0000305}.	amelogenesis [GO:0097186]; bicarbonate transport [GO:0015701]; cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; chloride transmembrane transport [GO:1902476]; cholesterol biosynthetic process [GO:0006695]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; intracellular pH elevation [GO:0051454]; membrane hyperpolarization [GO:0060081]; multicellular organismal-level water homeostasis [GO:0050891]; positive regulation of cyclic nucleotide-gated ion channel activity [GO:1902161]; positive regulation of enamel mineralization [GO:0070175]; positive regulation of exocytosis [GO:0045921]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of voltage-gated chloride channel activity [GO:1902943]; response to endoplasmic reticulum stress [GO:0034976]; sperm capacitation [GO:0048240]; transepithelial water transport [GO:0035377]; transmembrane transport [GO:0055085]; vesicle docking involved in exocytosis [GO:0006904]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; chloride channel complex [GO:0034707]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi-associated vesicle membrane [GO:0030660]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride channel inhibitor activity [GO:0019869]; chloride channel regulator activity [GO:0017081]; chloride transmembrane transporter activity [GO:0015108]; enzyme binding [GO:0019899]; intracellularly ATP-gated chloride channel activity [GO:0005260]; isomerase activity [GO:0016853]; PDZ domain binding [GO:0030165]; protein-folding chaperone binding [GO:0051087]; Sec61 translocon complex binding [GO:0106138]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; chloride channel complex [GO:0034707]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi-associated vesicle membrane [GO:0030660]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride channel inhibitor activity [GO:0019869]; chloride channel regulator activity [GO:0017081]; chloride transmembrane transporter activity [GO:0015108]; enzyme binding [GO:0019899]; intracellularly ATP-gated chloride channel activity [GO:0005260]; isomerase activity [GO:0016853]; PDZ domain binding [GO:0030165]; protein-folding chaperone binding [GO:0051087]; Sec61 translocon complex binding [GO:0106138]; amelogenesis [GO:0097186]; bicarbonate transport [GO:0015701]; cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; chloride transmembrane transport [GO:1902476]; cholesterol biosynthetic process [GO:0006695]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; intracellular pH elevation [GO:0051454]; membrane hyperpolarization [GO:0060081]; multicellular organismal-level water homeostasis [GO:0050891]; positive regulation of cyclic nucleotide-gated ion channel activity [GO:1902161]; positive regulation of enamel mineralization [GO:0070175]; positive regulation of exocytosis [GO:0045921]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of voltage-gated chloride channel activity [GO:1902943]; response to endoplasmic reticulum stress [GO:0034976]; sperm capacitation [GO:0048240]; transepithelial water transport [GO:0035377]; transmembrane transport [GO:0055085]; vesicle docking involved in exocytosis [GO:0006904]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:1284548, ECO:0000269|PubMed:15247260, ECO:0000269|PubMed:15716351, ECO:0000269|PubMed:17462998, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:20008117, ECO:0000269|PubMed:22207244, ECO:0000269|PubMed:28130590}; Multi-pass membrane protein {ECO:0000269|Ref.55}. Early endosome membrane {ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20008117}; Multi-pass membrane protein {ECO:0000269|Ref.55}. Cell membrane {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:28001373, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:28130590, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:8910473}; Multi-pass membrane protein {ECO:0000269|Ref.55}. Recycling endosome membrane {ECO:0000305|PubMed:17462998}; Multi-pass membrane protein {ECO:0000269|Ref.55}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:25330774}; Multi-pass membrane protein {ECO:0000269|Ref.55}. Nucleus {ECO:0000250|UniProtKB:P34158}. Note=The channel is internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:17462998, PubMed:19398555, PubMed:20008117). In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia (PubMed:22207244). In Sertoli cells, a processed product is detected in the nucleus (By similarity). ER stress induces GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:P34158, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20008117, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22207244, ECO:0000305|PubMed:17462998}.
P13584	reviewed	CP4B1_HUMAN	Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (Cytochrome P450-HP)	CYP4B1	Homo sapiens (Human)	511	FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.		biphenyl metabolic process [GO:0018879]; fatty acid metabolic process [GO:0006631]	endoplasmic reticulum membrane [GO:0005789]	aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxygen binding [GO:0019825]	endoplasmic reticulum membrane [GO:0005789]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxygen binding [GO:0019825]; biphenyl metabolic process [GO:0018879]; fatty acid metabolic process [GO:0006631]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
P13591	reviewed	NCAM1_HUMAN	Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56)	NCAM1 NCAM	Homo sapiens (Human)	858	FUNCTION: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.; FUNCTION: (Microbial infection) Acts as a receptor for rabies virus. {ECO:0000269|PubMed:9696812}.; FUNCTION: (Microbial infection) Acts as a receptor for Zika virus. {ECO:0000269|PubMed:32753727}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell adhesion [GO:0007155]; commissural neuron axon guidance [GO:0071679]; epithelial to mesenchymal transition [GO:0001837]; regulation of semaphorin-plexin signaling pathway [GO:2001260]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	virus receptor activity [GO:0001618]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; virus receptor activity [GO:0001618]; cell adhesion [GO:0007155]; commissural neuron axon guidance [GO:0071679]; epithelial to mesenchymal transition [GO:0001837]; regulation of semaphorin-plexin signaling pathway [GO:2001260]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted {ECO:0000305}.
P13598	reviewed	ICAM2_HUMAN	Intercellular adhesion molecule 2 (ICAM-2) (CD antigen CD102)	ICAM2	Homo sapiens (Human)	275	FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.		cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]	cleavage furrow [GO:0032154]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; uropod [GO:0001931]	integrin binding [GO:0005178]	cleavage furrow [GO:0032154]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; uropod [GO:0001931]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P35330}. Note=Co-localizes with RDX, EZR and MSN in microvilli. {ECO:0000250|UniProtKB:P35330}.
P13611	reviewed	CSPG2_HUMAN	Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M)	VCAN CSPG2	Homo sapiens (Human)	3396	FUNCTION: May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.		cell adhesion [GO:0007155]; cell recognition [GO:0008037]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; glial cell migration [GO:0008347]; osteoblast differentiation [GO:0001649]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; interphotoreceptor matrix [GO:0033165]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; perineuronal net [GO:0072534]; photoreceptor outer segment [GO:0001750]; synapse [GO:0045202]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; glycosaminoglycan binding [GO:0005539]; hyaluronic acid binding [GO:0005540]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; interphotoreceptor matrix [GO:0033165]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; perineuronal net [GO:0072534]; photoreceptor outer segment [GO:0001750]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; glycosaminoglycan binding [GO:0005539]; hyaluronic acid binding [GO:0005540]; cell adhesion [GO:0007155]; cell recognition [GO:0008037]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; glial cell migration [GO:0008347]; osteoblast differentiation [GO:0001649]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:2583089}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:29777959}. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix {ECO:0000269|PubMed:29777959}. Secreted {ECO:0000269|PubMed:25326458}.
P13612	reviewed	ITA4_HUMAN	Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)	ITGA4 CD49D	Homo sapiens (Human)	1032	FUNCTION: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). {ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877}.		axonogenesis involved in innervation [GO:0060385]; B cell differentiation [GO:0030183]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-cell adhesion in response to extracellular stimulus [GO:0140039]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-matrix adhesion involved in ameboidal cell migration [GO:0003366]; cellular response to amyloid-beta [GO:1904646]; cellular response to cytokine stimulus [GO:0071345]; clathrin-dependent extracellular exosome endocytosis [GO:1990771]; diapedesis [GO:0050904]; endodermal cell differentiation [GO:0035987]; heterotypic cell-cell adhesion [GO:0034113]; immune response in gut-associated lymphoid tissue [GO:0002387]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; negative regulation of protein homodimerization activity [GO:0090074]; neuron projection extension [GO:1990138]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; receptor clustering [GO:0043113]; substrate adhesion-dependent cell spreading [GO:0034446]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; integrin alpha4-beta1 complex [GO:0034668]; integrin alpha4-beta7 complex [GO:0034669]; integrin complex [GO:0008305]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; protein antigen binding [GO:1990405]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; integrin alpha4-beta1 complex [GO:0034668]; integrin alpha4-beta7 complex [GO:0034669]; integrin complex [GO:0008305]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; protein antigen binding [GO:1990405]; axonogenesis involved in innervation [GO:0060385]; B cell differentiation [GO:0030183]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-cell adhesion in response to extracellular stimulus [GO:0140039]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-matrix adhesion involved in ameboidal cell migration [GO:0003366]; cellular response to amyloid-beta [GO:1904646]; cellular response to cytokine stimulus [GO:0071345]; clathrin-dependent extracellular exosome endocytosis [GO:1990771]; diapedesis [GO:0050904]; endodermal cell differentiation [GO:0035987]; heterotypic cell-cell adhesion [GO:0034113]; immune response in gut-associated lymphoid tissue [GO:0002387]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; negative regulation of protein homodimerization activity [GO:0090074]; neuron projection extension [GO:1990138]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; receptor clustering [GO:0043113]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P13631	reviewed	RARG_HUMAN	Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3)	RARG NR1B3	Homo sapiens (Human)	454	FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). {ECO:0000250}.		anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; embryonic camera-type eye development [GO:0031076]; embryonic eye morphogenesis [GO:0048048]; embryonic hindlimb morphogenesis [GO:0035116]; face development [GO:0060324]; glandular epithelial cell development [GO:0002068]; growth plate cartilage chondrocyte growth [GO:0003430]; Harderian gland development [GO:0070384]; hormone-mediated signaling pathway [GO:0009755]; multicellular organism growth [GO:0035264]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland epithelium morphogenesis [GO:0060740]; regulation of cell size [GO:0008361]; regulation of myelination [GO:0031641]; regulation of myeloid cell differentiation [GO:0045637]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]; stem cell proliferation [GO:0072089]; trachea cartilage development [GO:0060534]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; embryonic camera-type eye development [GO:0031076]; embryonic eye morphogenesis [GO:0048048]; embryonic hindlimb morphogenesis [GO:0035116]; face development [GO:0060324]; glandular epithelial cell development [GO:0002068]; growth plate cartilage chondrocyte growth [GO:0003430]; Harderian gland development [GO:0070384]; hormone-mediated signaling pathway [GO:0009755]; multicellular organism growth [GO:0035264]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland epithelium morphogenesis [GO:0060740]; regulation of cell size [GO:0008361]; regulation of myelination [GO:0031641]; regulation of myeloid cell differentiation [GO:0045637]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]; stem cell proliferation [GO:0072089]; trachea cartilage development [GO:0060534]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28167758}. Cytoplasm {ECO:0000269|PubMed:28167758}.
P13637	reviewed	AT1A3_HUMAN	Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3)	ATP1A3	Homo sapiens (Human)	1013	FUNCTION: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}.		cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to amyloid-beta [GO:1904646]; cellular response to steroid hormone stimulus [GO:0071383]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; neuron projection maintenance [GO:1990535]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of resting membrane potential [GO:0060075]; response to glycoside [GO:1903416]; sodium ion export across plasma membrane [GO:0036376]	axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuron to neuron synapse [GO:0098984]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; organelle membrane [GO:0031090]; photoreceptor inner segment [GO:0001917]; photoreceptor inner segment membrane [GO:0060342]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; synapse [GO:0045202]	amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; protein-folding chaperone binding [GO:0051087]; steroid hormone binding [GO:1990239]	axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuron to neuron synapse [GO:0098984]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; organelle membrane [GO:0031090]; photoreceptor inner segment [GO:0001917]; photoreceptor inner segment membrane [GO:0060342]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; synapse [GO:0045202]; amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; protein-folding chaperone binding [GO:0051087]; steroid hormone binding [GO:1990239]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to amyloid-beta [GO:1904646]; cellular response to steroid hormone stimulus [GO:0071383]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; neuron projection maintenance [GO:1990535]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of resting membrane potential [GO:0060075]; response to glycoside [GO:1903416]; sodium ion export across plasma membrane [GO:0036376]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000269|PubMed:7711835}.
P13639	reviewed	EF2_HUMAN	Elongation factor 2 (EF-2) (EC 3.6.5.-)	EEF2 EF2	Homo sapiens (Human)	858	FUNCTION: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}.		hematopoietic progenitor cell differentiation [GO:0002244]; positive regulation of translation [GO:0045727]; translational elongation [GO:0006414]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]; synapse [GO:0045202]	cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]; synapse [GO:0045202]; cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; hematopoietic progenitor cell differentiation [GO:0002244]; positive regulation of translation [GO:0045727]; translational elongation [GO:0006414]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25064856}. Nucleus {ECO:0000269|PubMed:24648518}. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. {ECO:0000269|PubMed:24648518}.
P13640	reviewed	MT1G_HUMAN	Metallothionein-1G (MT-1G) (Metallothionein-1K) (MT-1K) (Metallothionein-IG) (MT-IG)	MT1G MT1K MT1M	Homo sapiens (Human)	62	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.		cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; monocyte activation [GO:0042117]; monocyte differentiation [GO:0030224]; negative regulation of growth [GO:0045926]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; monocyte activation [GO:0042117]; monocyte differentiation [GO:0030224]; negative regulation of growth [GO:0045926]	
P13645	reviewed	K1C10_HUMAN	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)	KRT10 KPP	Homo sapiens (Human)	584	FUNCTION: Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium (By similarity). {ECO:0000250|UniProtKB:P02535}.; FUNCTION: (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization. {ECO:0000269|PubMed:15385531}.; FUNCTION: (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur. {ECO:0000269|PubMed:19627498}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; positive regulation of epidermis development [GO:0045684]; protein heterotetramerization [GO:0051290]	cell surface [GO:0009986]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634]	protein heterodimerization activity [GO:0046982]; structural constituent of skin epidermis [GO:0030280]	cell surface [GO:0009986]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634]; protein heterodimerization activity [GO:0046982]; structural constituent of skin epidermis [GO:0030280]; epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; positive regulation of epidermis development [GO:0045684]; protein heterotetramerization [GO:0051290]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:12427098}. Cell surface {ECO:0000269|PubMed:19627498}. Cytoplasm {ECO:0000269|PubMed:32179842}.
P13646	reviewed	K1C13_HUMAN	Keratin, type I cytoskeletal 13 (Cytokeratin-13) (CK-13) (Keratin-13) (K13)	KRT13	Homo sapiens (Human)	458	FUNCTION: Type 1 keratin (Probable). Maintains postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially via regulation of the G1/S phase cyclins CCNE1 and CCNE2 (By similarity). {ECO:0000250|UniProtKB:P08730, ECO:0000305}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; regulation of translation in response to stress [GO:0043555]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nucleus [GO:0005634]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nucleus [GO:0005634]; structural molecule activity [GO:0005198]; cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; regulation of translation in response to stress [GO:0043555]	
P13647	reviewed	K2C5_HUMAN	Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)	KRT5	Homo sapiens (Human)	590	FUNCTION: Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity). {ECO:0000250|UniProtKB:Q922U2}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; intermediate filament polymerization [GO:0045107]; keratinization [GO:0031424]; regulation of cell migration [GO:0030334]; regulation of protein localization [GO:0032880]; response to mechanical stimulus [GO:0009612]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634]	scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280]; epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; intermediate filament polymerization [GO:0045107]; keratinization [GO:0031424]; regulation of cell migration [GO:0030334]; regulation of protein localization [GO:0032880]; response to mechanical stimulus [GO:0009612]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20128788}.
P13667	reviewed	PDIA4_HUMAN	Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)	PDIA4 ERP70 ERP72	Homo sapiens (Human)	645			chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; protein secretion [GO:0009306]; response to endoplasmic reticulum stress [GO:0034976]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; melanosome [GO:0042470]	protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; melanosome [GO:0042470]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723]; chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; protein secretion [GO:0009306]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:12643545}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065}.
P13671	reviewed	CO6_HUMAN	Complement component C6	C6	Homo sapiens (Human)	934	FUNCTION: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.		complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886]		extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]	SUBCELLULAR LOCATION: Secreted.
P13674	reviewed	P4HA1_HUMAN	Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)	P4HA1 P4HA	Homo sapiens (Human)	534	FUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:9211872}.		collagen fibril organization [GO:0030199]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; procollagen-proline 4-dioxygenase complex [GO:0016222]	identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; procollagen-proline 4-dioxygenase complex [GO:0016222]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656]; collagen fibril organization [GO:0030199]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
P13682	reviewed	ZNF35_HUMAN	Zinc finger protein 35 (Zinc finger protein HF.10)	ZNF35	Homo sapiens (Human)	527	FUNCTION: May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.		cellular response to retinoic acid [GO:0071300]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; cellular response to retinoic acid [GO:0071300]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P13686	reviewed	PPA5_HUMAN	Tartrate-resistant acid phosphatase type 5 (TR-AP) (EC 3.1.3.2) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase)	ACP5	Homo sapiens (Human)	325	FUNCTION: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.		bone morphogenesis [GO:0060349]; bone resorption [GO:0045453]; defense response to Gram-positive bacterium [GO:0050830]; dephosphorylation [GO:0016311]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of superoxide anion generation [GO:0032929]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide biosynthetic process [GO:0006809]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; superoxide anion generation [GO:0042554]	cytosol [GO:0005829]; lysosome [GO:0005764]; membrane [GO:0016020]	acid phosphatase activity [GO:0003993]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]	cytosol [GO:0005829]; lysosome [GO:0005764]; membrane [GO:0016020]; acid phosphatase activity [GO:0003993]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; bone morphogenesis [GO:0060349]; bone resorption [GO:0045453]; defense response to Gram-positive bacterium [GO:0050830]; dephosphorylation [GO:0016311]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of superoxide anion generation [GO:0032929]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide biosynthetic process [GO:0006809]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; superoxide anion generation [GO:0042554]	SUBCELLULAR LOCATION: Lysosome.
P13688	reviewed	CEAM1_HUMAN	Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (CD antigen CD66a)	CEACAM1 BGP BGP1	Homo sapiens (Human)	526	FUNCTION: [Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R by down-regulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Down-regulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809, ECO:0000269|PubMed:16291724, ECO:0000269|PubMed:18424730, ECO:0000269|PubMed:23696226, ECO:0000269|PubMed:25363763}.; FUNCTION: [Isoform 8]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809}.	MISCELLANEOUS: [Isoform 8]: Pseudophosphorylated double mutant Thr-457->Asp and Ser-459->Asp. The single mutant Ser-459->Asp mutant highly binds with ANXA2. {ECO:0000269|PubMed:14522961}.	angiogenesis [GO:0001525]; bile acid and bile salt transport [GO:0015721]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cellular response to insulin stimulus [GO:0032869]; common myeloid progenitor cell proliferation [GO:0035726]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; insulin catabolic process [GO:1901143]; insulin receptor internalization [GO:0038016]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of lipid biosynthetic process [GO:0051055]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of vascular permeability [GO:0043116]; positive regulation of vasculogenesis [GO:2001214]; regulation of blood vessel remodeling [GO:0060312]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of endothelial cell differentiation [GO:0045601]; regulation of endothelial cell migration [GO:0010594]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of homophilic cell adhesion [GO:1903385]; regulation of immune system process [GO:0002682]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of sprouting angiogenesis [GO:1903670]; signal transduction [GO:0007165]; wound healing, spreading of cells [GO:0044319]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; transport vesicle membrane [GO:0030658]	actin binding [GO:0003779]; bile acid transmembrane transporter activity [GO:0015125]; calmodulin binding [GO:0005516]; filamin binding [GO:0031005]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; transport vesicle membrane [GO:0030658]; actin binding [GO:0003779]; bile acid transmembrane transporter activity [GO:0015125]; calmodulin binding [GO:0005516]; filamin binding [GO:0031005]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; angiogenesis [GO:0001525]; bile acid and bile salt transport [GO:0015721]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cellular response to insulin stimulus [GO:0032869]; common myeloid progenitor cell proliferation [GO:0035726]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; insulin catabolic process [GO:1901143]; insulin receptor internalization [GO:0038016]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of lipid biosynthetic process [GO:0051055]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of vascular permeability [GO:0043116]; positive regulation of vasculogenesis [GO:2001214]; regulation of blood vessel remodeling [GO:0060312]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of endothelial cell differentiation [GO:0045601]; regulation of endothelial cell migration [GO:0010594]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of homophilic cell adhesion [GO:1903385]; regulation of immune system process [GO:0002682]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of sprouting angiogenesis [GO:1903670]; signal transduction [GO:0007165]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:P16573}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16573}. Lateral cell membrane {ECO:0000250|UniProtKB:P16573}. Apical cell membrane {ECO:0000250|UniProtKB:P16573}. Basal cell membrane {ECO:0000250|UniProtKB:P16573}. Cell junction {ECO:0000269|PubMed:16291724}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P16573}. Note=Canalicular domain of hepatocyte plasma membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions. Found as dimer in the solution. Predominantly localized to the lateral cell membranes. {ECO:0000250|UniProtKB:P16573}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:2025273}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:2025273}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000269|PubMed:2025273}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 7]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 8]: Cell membrane {ECO:0000269|PubMed:14522961}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16573}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:14522961}. Lateral cell membrane {ECO:0000250|UniProtKB:P16573}. Apical cell membrane {ECO:0000250|UniProtKB:P16573}. Basal cell membrane {ECO:0000250|UniProtKB:P16573}. Cell junction {ECO:0000269|PubMed:8018919}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P16573}. Note=Predominantly localized to the lateral cell membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (By similarity). Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (PubMed:14522961). {ECO:0000250|UniProtKB:P16573, ECO:0000269|PubMed:14522961}.; SUBCELLULAR LOCATION: Cell projection, microvillus membrane {ECO:0000250|UniProtKB:P31809}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:10436421}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized to the apical glycocalyx surface (PubMed:10436421). Colocalizes with CEACAM20 at the apical brush border of intestinal cells. {ECO:0000250|UniProtKB:P31809, ECO:0000269|PubMed:10436421}.
P13693	reviewed	TCTP_HUMAN	Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23)	TPT1	Homo sapiens (Human)	172	FUNCTION: Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:18325344). {ECO:0000269|PubMed:12167714, ECO:0000269|PubMed:15162379, ECO:0000269|PubMed:15958728, ECO:0000269|PubMed:18325344}.		calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ectoderm development [GO:2000384]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; regulation of apoptotic process [GO:0042981]; response to virus [GO:0009615]; stem cell population maintenance [GO:0019827]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	calcium ion binding [GO:0005509]; DNA-binding transcription factor binding [GO:0140297]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; calcium ion binding [GO:0005509]; DNA-binding transcription factor binding [GO:0140297]; RNA binding [GO:0003723]; calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ectoderm development [GO:2000384]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; regulation of apoptotic process [GO:0042981]; response to virus [GO:0009615]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9059837}.
P13716	reviewed	HEM2_HUMAN	Delta-aminolevulinic acid dehydratase (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase)	ALAD	Homo sapiens (Human)	330	FUNCTION: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. {ECO:0000269|PubMed:11032836, ECO:0000269|PubMed:19812033}.		cellular response to interleukin-4 [GO:0071353]; cellular response to lead ion [GO:0071284]; heme biosynthetic process [GO:0006783]; negative regulation of proteasomal protein catabolic process [GO:1901799]; protein homooligomerization [GO:0051260]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to activity [GO:0014823]; response to aluminum ion [GO:0010044]; response to amino acid [GO:0043200]; response to arsenic-containing substance [GO:0046685]; response to cadmium ion [GO:0046686]; response to cobalt ion [GO:0032025]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to herbicide [GO:0009635]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to iron ion [GO:0010039]; response to lipopolysaccharide [GO:0032496]; response to mercury ion [GO:0046689]; response to methylmercury [GO:0051597]; response to oxidative stress [GO:0006979]; response to platinum ion [GO:0070541]; response to selenium ion [GO:0010269]; response to vitamin B1 [GO:0010266]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]	catalytic activity [GO:0003824]; identical protein binding [GO:0042802]; porphobilinogen synthase activity [GO:0004655]; proteasome core complex binding [GO:1904854]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; catalytic activity [GO:0003824]; identical protein binding [GO:0042802]; porphobilinogen synthase activity [GO:0004655]; proteasome core complex binding [GO:1904854]; zinc ion binding [GO:0008270]; cellular response to interleukin-4 [GO:0071353]; cellular response to lead ion [GO:0071284]; heme biosynthetic process [GO:0006783]; negative regulation of proteasomal protein catabolic process [GO:1901799]; protein homooligomerization [GO:0051260]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to activity [GO:0014823]; response to aluminum ion [GO:0010044]; response to amino acid [GO:0043200]; response to arsenic-containing substance [GO:0046685]; response to cadmium ion [GO:0046686]; response to cobalt ion [GO:0032025]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to herbicide [GO:0009635]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to iron ion [GO:0010039]; response to lipopolysaccharide [GO:0032496]; response to mercury ion [GO:0046689]; response to methylmercury [GO:0051597]; response to oxidative stress [GO:0006979]; response to platinum ion [GO:0070541]; response to selenium ion [GO:0010269]; response to vitamin B1 [GO:0010266]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]	
P13725	reviewed	ONCM_HUMAN	Oncostatin-M (OSM)	OSM	Homo sapiens (Human)	252	FUNCTION: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:1542792, ECO:0000269|PubMed:1542793}.		immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hormone secretion [GO:0046888]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of hematopoietic stem cell differentiation [GO:1902036]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; oncostatin-M receptor binding [GO:0005147]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; oncostatin-M receptor binding [GO:0005147]; immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hormone secretion [GO:0046888]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of hematopoietic stem cell differentiation [GO:1902036]	SUBCELLULAR LOCATION: Secreted.
P13726	reviewed	TF_HUMAN	Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)	F3	Homo sapiens (Human)	295	FUNCTION: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. {ECO:0000269|PubMed:12652293}.		activation of blood coagulation via clotting cascade [GO:0002543]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of plasma proteins involved in acute inflammatory response [GO:0002541]; blood coagulation [GO:0007596]; cytokine-mediated signaling pathway [GO:0019221]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet-derived growth factor receptor signaling pathway [GO:0010641]; positive regulation of positive chemotaxis [GO:0050927]; protein processing [GO:0016485]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; serine-type peptidase complex [GO:1905286]	cytokine receptor activity [GO:0004896]; phospholipid binding [GO:0005543]; protease binding [GO:0002020]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; serine-type peptidase complex [GO:1905286]; cytokine receptor activity [GO:0004896]; phospholipid binding [GO:0005543]; protease binding [GO:0002020]; activation of blood coagulation via clotting cascade [GO:0002543]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of plasma proteins involved in acute inflammatory response [GO:0002541]; blood coagulation [GO:0007596]; cytokine-mediated signaling pathway [GO:0019221]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet-derived growth factor receptor signaling pathway [GO:0010641]; positive regulation of positive chemotaxis [GO:0050927]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000269|PubMed:12652293}; Single-pass type I membrane protein {ECO:0000269|PubMed:12652293}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:12652293}.
P13727	reviewed	PRG2_HUMAN	Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]	PRG2 MBP	Homo sapiens (Human)	222	FUNCTION: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. {ECO:0000269|PubMed:10913121}.	MISCELLANEOUS: Binds heparin. Does not bind calcium.	defense response to bacterium [GO:0042742]; defense response to nematode [GO:0002215]; immune response [GO:0006955]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of macrophage cytokine production [GO:0010936]; positive regulation of interleukin-4 production [GO:0032753]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; transport vesicle [GO:0030133]	carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; heparin binding [GO:0008201]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; transport vesicle [GO:0030133]; carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; heparin binding [GO:0008201]; defense response to bacterium [GO:0042742]; defense response to nematode [GO:0002215]; immune response [GO:0006955]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of macrophage cytokine production [GO:0010936]; positive regulation of interleukin-4 production [GO:0032753]	SUBCELLULAR LOCATION: [Bone marrow proteoglycan]: Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313}. Note=The proform is secreted.; SUBCELLULAR LOCATION: [Eosinophil granule major basic protein]: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
P13747	reviewed	HLAE_HUMAN	HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]	HLA-E HLA-6.2 HLAE	Homo sapiens (Human)	358	FUNCTION: Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides - VMAPRT[V/L][L/V/I/F]L) (PubMed:9754572, PubMed:18083576, PubMed:37264229, PubMed:18339401, PubMed:35705051). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576, PubMed:37264229). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159, PubMed:37264229). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8-positive cytotoxic T cells, ultimately triggering antimicrobial immune response (PubMed:16474394, PubMed:30087334, PubMed:20195504, PubMed:34228645). Presents HIV gag peptides (immunodominant KAFSPEVIPMF and subdominant KALGPAATL epitopes) predominantly to CD8-positive T cell clones expressing a TRAV17-containing TCR, triggering HLA-E-restricted T cell responses (PubMed:34228645). Presents mycobacterial peptides to HLA-E-restricted CD8-positive T cells eliciting both cytotoxic and immunoregulatory functions (PubMed:20195504, PubMed:35705051). {ECO:0000269|PubMed:12461076, ECO:0000269|PubMed:16474394, ECO:0000269|PubMed:17179229, ECO:0000269|PubMed:18083576, ECO:0000269|PubMed:18339401, ECO:0000269|PubMed:20195504, ECO:0000269|PubMed:30087334, ECO:0000269|PubMed:30134159, ECO:0000269|PubMed:34228645, ECO:0000269|PubMed:35705051, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9486650, ECO:0000269|PubMed:9754572}.; FUNCTION: (Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells. {ECO:0000269|PubMed:10799855, ECO:0000269|PubMed:23335510}.; FUNCTION: (Microbial infection) May bind HIV-1 gag/Capsid protein p24-derived peptide (AISPRTLNA) on infected cells and may inhibit NK cell cytotoxicity, a mechanism that allows HIV-1 to escape immune recognition. {ECO:0000269|PubMed:15751767}.; FUNCTION: (Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells (PubMed:32859121). Binds SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening of antiviral immune surveillance (PubMed:32859121). {ECO:0000269|PubMed:32859121}.		adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; antigen processing and presentation of exogenous peptide antigen via MHC class Ib [GO:0002477]; CD8-positive, alpha-beta T cell activation [GO:0036037]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; innate immune response [GO:0045087]; natural killer cell tolerance induction [GO:0002519]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of antibody-dependent cellular cytotoxicity [GO:0001815]; positive regulation of CD8-positive, alpha-beta T cell activation [GO:2001187]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated immunity [GO:0002717]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of TRAIL production [GO:0032759]; positive regulation of tumor necrosis factor production [GO:0032760]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; regulation of natural killer cell mediated immunity [GO:0002715]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; MHC class Ib protein complex [GO:0032398]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	beta-2-microglobulin binding [GO:0030881]; MHC class I protein binding [GO:0042288]; natural killer cell lectin-like receptor binding [GO:0046703]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; MHC class Ib protein complex [GO:0032398]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; beta-2-microglobulin binding [GO:0030881]; MHC class I protein binding [GO:0042288]; natural killer cell lectin-like receptor binding [GO:0046703]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; antigen processing and presentation of exogenous peptide antigen via MHC class Ib [GO:0002477]; CD8-positive, alpha-beta T cell activation [GO:0036037]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; innate immune response [GO:0045087]; natural killer cell tolerance induction [GO:0002519]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of antibody-dependent cellular cytotoxicity [GO:0001815]; positive regulation of CD8-positive, alpha-beta T cell activation [GO:2001187]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated immunity [GO:0002717]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of TRAIL production [GO:0032759]; positive regulation of tumor necrosis factor production [GO:0032760]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; regulation of natural killer cell mediated immunity [GO:0002715]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17179229, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9427624}; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000269|PubMed:17179229}.; SUBCELLULAR LOCATION: [Soluble HLA class I histocompatibility antigen, alpha chain E]: Secreted {ECO:0000269|PubMed:17179229}.
P13762	reviewed	DRB4_HUMAN	HLA class II histocompatibility antigen, DR beta 4 chain (MHC class II antigen DRB4)	HLA-DRB4	Homo sapiens (Human)	266	FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]	MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
P13765	reviewed	DOB_HUMAN	HLA class II histocompatibility antigen, DO beta chain (MHC class II antigen DOB)	HLA-DOB	Homo sapiens (Human)	273	FUNCTION: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; negative regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002587]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; MHC class II protein complex [GO:0042613]	MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; MHC class II protein complex [GO:0042613]; MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; negative regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002587]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	SUBCELLULAR LOCATION: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
P13796	reviewed	PLSL_HUMAN	Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1)	LCP1 PLS2	Homo sapiens (Human)	627	FUNCTION: Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}.		actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; animal organ regeneration [GO:0031100]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; extracellular matrix disassembly [GO:0022617]; positive regulation of podosome assembly [GO:0071803]; protein kinase A signaling [GO:0010737]; regulation of intracellular protein transport [GO:0033157]; T cell activation involved in immune response [GO:0002286]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; actin filament bundle [GO:0032432]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glial cell projection [GO:0097386]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; GTPase binding [GO:0051020]; integrin binding [GO:0005178]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; actin filament bundle [GO:0032432]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glial cell projection [GO:0097386]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; GTPase binding [GO:0051020]; integrin binding [GO:0005178]; actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; animal organ regeneration [GO:0031100]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; extracellular matrix disassembly [GO:0022617]; positive regulation of podosome assembly [GO:0071803]; protein kinase A signaling [GO:0010737]; regulation of intracellular protein transport [GO:0033157]; T cell activation involved in immune response [GO:0002286]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16636079}. Cell junction {ECO:0000269|PubMed:17294403}. Cell projection {ECO:0000269|PubMed:16636079}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q61233, ECO:0000269|PubMed:16636079}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q61233}; Cytoplasmic side {ECO:0000250|UniProtKB:Q61233}. Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Associated with the actin cytoskeleton at membrane ruffles. Relocalizes to actin-rich cell projections upon serine phosphorylation (PubMed:16636079). {ECO:0000250|UniProtKB:Q61233, ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403}.
P13797	reviewed	PLST_HUMAN	Plastin-3 (T-plastin)	PLS3	Homo sapiens (Human)	630	FUNCTION: Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.		actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; bone development [GO:0060348]	actin filament [GO:0005884]; actin filament bundle [GO:0032432]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]	actin filament [GO:0005884]; actin filament bundle [GO:0032432]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; bone development [GO:0060348]	SUBCELLULAR LOCATION: Cytoplasm.
P13798	reviewed	ACPH_HUMAN	Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH)	APEH D3F15S2 D3S48E DNF15S2	Homo sapiens (Human)	732	FUNCTION: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:10719179, PubMed:2006156, PubMed:1740429). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins (PubMed:10719179). {ECO:0000250|UniProtKB:P13676, ECO:0000269|PubMed:10719179, ECO:0000269|PubMed:1740429, ECO:0000269|PubMed:2006156}.		amyloid-beta metabolic process [GO:0050435]; proteolysis [GO:0006508]; translational termination [GO:0006415]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nuclear membrane [GO:0031965]	identical protein binding [GO:0042802]; omega peptidase activity [GO:0008242]; RNA binding [GO:0003723]; serine-type endopeptidase activity [GO:0004252]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nuclear membrane [GO:0031965]; identical protein binding [GO:0042802]; omega peptidase activity [GO:0008242]; RNA binding [GO:0003723]; serine-type endopeptidase activity [GO:0004252]; amyloid-beta metabolic process [GO:0050435]; proteolysis [GO:0006508]; translational termination [GO:0006415]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10719179}.
P13804	reviewed	ETFA_HUMAN	Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF)	ETFA	Homo sapiens (Human)	333	FUNCTION: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}.		amino acid catabolic process [GO:0009063]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904]	electron transfer flavoprotein complex [GO:0045251]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity [GO:0016491]	electron transfer flavoprotein complex [GO:0045251]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity [GO:0016491]; amino acid catabolic process [GO:0009063]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305}.
P13805	reviewed	TNNT1_HUMAN	Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT)	TNNT1 TNT	Homo sapiens (Human)	278	FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.		negative regulation of muscle contraction [GO:0045932]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]; slow-twitch skeletal muscle fiber contraction [GO:0031444]; transition between fast and slow fiber [GO:0014883]	cytosol [GO:0005829]; troponin complex [GO:0005861]	tropomyosin binding [GO:0005523]; troponin T binding [GO:0031014]	cytosol [GO:0005829]; troponin complex [GO:0005861]; tropomyosin binding [GO:0005523]; troponin T binding [GO:0031014]; negative regulation of muscle contraction [GO:0045932]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]; slow-twitch skeletal muscle fiber contraction [GO:0031444]; transition between fast and slow fiber [GO:0014883]	
P13807	reviewed	GYS1_HUMAN	Glycogen [starch] synthase, muscle (EC 2.4.1.11)	GYS1 GYS	Homo sapiens (Human)	737	FUNCTION: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000250|UniProtKB:P13834}.		glycogen biosynthetic process [GO:0005978]; heart development [GO:0007507]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; membrane [GO:0016020]	glucose binding [GO:0005536]; glycogen (starch) synthase activity [GO:0004373]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; membrane [GO:0016020]; glucose binding [GO:0005536]; glycogen (starch) synthase activity [GO:0004373]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547]; protein kinase binding [GO:0019901]; glycogen biosynthetic process [GO:0005978]; heart development [GO:0007507]	
P13861	reviewed	KAP2_HUMAN	cAMP-dependent protein kinase type II-alpha regulatory subunit	PRKAR2A PKR2 PRKAR2	Homo sapiens (Human)	404	FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.		intracellular signal transduction [GO:0035556]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]	cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleotide-activated protein kinase complex [GO:0031588]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; protein-containing complex [GO:0032991]	cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein domain specific binding [GO:0019904]; protein kinase A catalytic subunit binding [GO:0034236]; ubiquitin protein ligase binding [GO:0031625]	cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleotide-activated protein kinase complex [GO:0031588]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; protein-containing complex [GO:0032991]; cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein domain specific binding [GO:0019904]; protein kinase A catalytic subunit binding [GO:0034236]; ubiquitin protein ligase binding [GO:0031625]; intracellular signal transduction [GO:0035556]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane.
P13866	reviewed	SC5A1_HUMAN	Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1)	SLC5A1 NAGT SGLT1	Homo sapiens (Human)	664	FUNCTION: Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:35077764, PubMed:8563765, PubMed:34880492). Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (PubMed:8563765) (By similarity). Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (PubMed:28974690). Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine. {ECO:0000250|UniProtKB:Q8C3K6, ECO:0000269|PubMed:14695256, ECO:0000269|PubMed:20980548, ECO:0000269|PubMed:26945065, ECO:0000269|PubMed:28974690, ECO:0000269|PubMed:34880492, ECO:0000269|PubMed:35077764, ECO:0000269|PubMed:8563765}.		alpha-glucoside transport [GO:0000017]; fucose transmembrane transport [GO:0015756]; galactose transmembrane transport [GO:0015757]; glucose import across plasma membrane [GO:0098708]; glucose transmembrane transport [GO:1904659]; intestinal D-glucose absorption [GO:0001951]; intestinal hexose absorption [GO:0106001]; myo-inositol transport [GO:0015798]; pentose transmembrane transport [GO:0015750]; renal glucose absorption [GO:0035623]; response to inorganic substance [GO:0010035]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transport [GO:0006814]; transepithelial water transport [GO:0035377]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; intracellular organelle [GO:0043229]; intracellular vesicle [GO:0097708]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	alpha-glucoside transmembrane transporter activity [GO:0015151]; D-glucose transmembrane transporter activity [GO:0055056]; fucose transmembrane transporter activity [GO:0015150]; galactose transmembrane transporter activity [GO:0005354]; galactose:sodium symporter activity [GO:0015371]; glucose transmembrane transporter activity [GO:0005355]; glucose:sodium symporter activity [GO:0005412]; myo-inositol:sodium symporter activity [GO:0005367]; pentose transmembrane transporter activity [GO:0015146]; water transmembrane transporter activity [GO:0005372]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; intracellular organelle [GO:0043229]; intracellular vesicle [GO:0097708]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; alpha-glucoside transmembrane transporter activity [GO:0015151]; D-glucose transmembrane transporter activity [GO:0055056]; fucose transmembrane transporter activity [GO:0015150]; galactose transmembrane transporter activity [GO:0005354]; galactose:sodium symporter activity [GO:0015371]; glucose transmembrane transporter activity [GO:0005355]; glucose:sodium symporter activity [GO:0005412]; myo-inositol:sodium symporter activity [GO:0005367]; pentose transmembrane transporter activity [GO:0015146]; water transmembrane transporter activity [GO:0005372]; alpha-glucoside transport [GO:0000017]; fucose transmembrane transport [GO:0015756]; galactose transmembrane transport [GO:0015757]; glucose import across plasma membrane [GO:0098708]; glucose transmembrane transport [GO:1904659]; intestinal D-glucose absorption [GO:0001951]; intestinal hexose absorption [GO:0106001]; myo-inositol transport [GO:0015798]; pentose transmembrane transport [GO:0015750]; renal glucose absorption [GO:0035623]; response to inorganic substance [GO:0010035]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transport [GO:0006814]; transepithelial water transport [GO:0035377]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:26945065}; Multi-pass membrane protein {ECO:0000255}.
P13928	reviewed	ANXA8_HUMAN	Annexin A8 (Annexin VIII) (Annexin-8) (Vascular anticoagulant-beta) (VAC-beta)	ANXA8 ANX8	Homo sapiens (Human)	327	FUNCTION: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.		blood coagulation [GO:0007596]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; negative regulation of phospholipase A2 activity [GO:1900138]; negative regulation of serine-type endopeptidase activity [GO:1900004]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; blood coagulation [GO:0007596]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; negative regulation of phospholipase A2 activity [GO:1900138]; negative regulation of serine-type endopeptidase activity [GO:1900004]	
P13929	reviewed	ENOB_HUMAN	Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase)	ENO3	Homo sapiens (Human)	434	FUNCTION: Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}.		canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; phosphopyruvate hydratase complex [GO:0000015]; plasma membrane [GO:0005886]	magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; phosphopyruvate hydratase complex [GO:0000015]; plasma membrane [GO:0005886]; magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]; canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]	SUBCELLULAR LOCATION: Cytoplasm. Note=Localized to the Z line. Some colocalization with CKM at M-band (By similarity). {ECO:0000250}.
P13942	reviewed	COBA2_HUMAN	Collagen alpha-2(XI) chain	COL11A2	Homo sapiens (Human)	1736	FUNCTION: May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.		cartilage development [GO:0051216]; collagen fibril organization [GO:0030199]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; soft palate development [GO:0060023]	collagen trimer [GO:0005581]; collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]	collagen trimer [GO:0005581]; collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; cartilage development [GO:0051216]; collagen fibril organization [GO:0030199]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; soft palate development [GO:0060023]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
P13945	reviewed	ADRB3_HUMAN	Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) (Beta-3 adrenoceptor)	ADRB3 ADRB3R B3AR	Homo sapiens (Human)	408	FUNCTION: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.		activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; brown fat cell differentiation [GO:0050873]; carbohydrate metabolic process [GO:0005975]; diet induced thermogenesis [GO:0002024]; eating behavior [GO:0042755]; energy reserve metabolic process [GO:0006112]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; generation of precursor metabolites and energy [GO:0006091]; heat generation [GO:0031649]; negative regulation of multicellular organism growth [GO:0040015]; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002025]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of MAPK cascade [GO:0043410]; response to cold [GO:0009409]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]	beta-3 adrenergic receptor binding [GO:0031699]; beta-adrenergic receptor activity [GO:0004939]; beta3-adrenergic receptor activity [GO:0015052]; epinephrine binding [GO:0051379]; norepinephrine binding [GO:0051380]; protein homodimerization activity [GO:0042803]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; beta-3 adrenergic receptor binding [GO:0031699]; beta-adrenergic receptor activity [GO:0004939]; beta3-adrenergic receptor activity [GO:0015052]; epinephrine binding [GO:0051379]; norepinephrine binding [GO:0051380]; protein homodimerization activity [GO:0042803]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; brown fat cell differentiation [GO:0050873]; carbohydrate metabolic process [GO:0005975]; diet induced thermogenesis [GO:0002024]; eating behavior [GO:0042755]; energy reserve metabolic process [GO:0006112]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; generation of precursor metabolites and energy [GO:0006091]; heat generation [GO:0031649]; negative regulation of multicellular organism growth [GO:0040015]; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002025]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of MAPK cascade [GO:0043410]; response to cold [GO:0009409]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P13984	reviewed	T2FB_HUMAN	General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30)	GTF2F2 RAP30	Homo sapiens (Human)	249	FUNCTION: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. {ECO:0000269|PubMed:2477704}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]	microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIF complex [GO:0005674]	DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIF complex [GO:0005674]; DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10454543}.
P13987	reviewed	CD59_HUMAN	CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59)	CD59 MIC11 MIN1 MIN2 MIN3 MSK21	Homo sapiens (Human)	128	FUNCTION: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.; FUNCTION: The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.		blood coagulation [GO:0007596]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of activation of membrane attack complex [GO:0001971]; regulation of complement activation [GO:0030449]; regulation of complement-dependent cytotoxicity [GO:1903659]	cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; transport vesicle [GO:0030133]; vesicle [GO:0031982]	complement binding [GO:0001848]	cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; transport vesicle [GO:0030133]; vesicle [GO:0031982]; complement binding [GO:0001848]; blood coagulation [GO:0007596]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of activation of membrane attack complex [GO:0001971]; regulation of complement activation [GO:0030449]; regulation of complement-dependent cytotoxicity [GO:1903659]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Soluble form found in a number of tissues.
P13994	reviewed	YJU2B_HUMAN	Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130)	YJU2B CCDC130 SB115	Homo sapiens (Human)	396	FUNCTION: May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}.		mRNA splicing, via spliceosome [GO:0000398]; response to virus [GO:0009615]; RNA splicing [GO:0008380]	post-mRNA release spliceosomal complex [GO:0071014]; U2-type spliceosomal complex [GO:0005684]		post-mRNA release spliceosomal complex [GO:0071014]; U2-type spliceosomal complex [GO:0005684]; mRNA splicing, via spliceosome [GO:0000398]; response to virus [GO:0009615]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BW85}.
P13995	reviewed	MTDC_HUMAN	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]	MTHFD2 NMDMC	Homo sapiens (Human)	350	FUNCTION: Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. {ECO:0000269|PubMed:16100107}.	MISCELLANEOUS: This NAD-dependent bifunctional enzyme has very different kinetic properties than the larger NADP-dependent trifunctional enzyme and is unique in that it requires formation of an enzyme-magnesium complex to allow binding of NAD.	folic acid metabolic process [GO:0046655]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	magnesium ion binding [GO:0000287]; methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; phosphate ion binding [GO:0042301]	extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; magnesium ion binding [GO:0000287]; methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; phosphate ion binding [GO:0042301]; folic acid metabolic process [GO:0046655]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	SUBCELLULAR LOCATION: Mitochondrion.
P14060	reviewed	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1) (Trophoblast antigen FDO161G)	HSD3B1 3BH HSDB3A	Homo sapiens (Human)	373	FUNCTION: A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1401999, PubMed:2139411). Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable). {ECO:0000269|PubMed:1401999, ECO:0000269|PubMed:2139411, ECO:0000305|PubMed:1401999}.		androgen biosynthetic process [GO:0006702]; C21-steroid hormone metabolic process [GO:0008207]; estrogen biosynthetic process [GO:0006703]; hippocampus development [GO:0021766]; response to corticosterone [GO:0051412]; steroid biosynthetic process [GO:0006694]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; nucleolus [GO:0005730]; smooth endoplasmic reticulum membrane [GO:0030868]	3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; 3-keto sterol reductase activity [GO:0000253]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; cholesterol dehydrogenase activity [GO:0102294]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid delta-isomerase activity [GO:0004769]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; nucleolus [GO:0005730]; smooth endoplasmic reticulum membrane [GO:0030868]; 3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; 3-keto sterol reductase activity [GO:0000253]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; cholesterol dehydrogenase activity [GO:0102294]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid delta-isomerase activity [GO:0004769]; androgen biosynthetic process [GO:0006702]; C21-steroid hormone metabolic process [GO:0008207]; estrogen biosynthetic process [GO:0006703]; hippocampus development [GO:0021766]; response to corticosterone [GO:0051412]; steroid biosynthetic process [GO:0006694]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
P14061	reviewed	DHB1_HUMAN	17-beta-hydroxysteroid dehydrogenase type 1 (17-beta-HSD 1) (EC 1.1.1.51) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 1) (EC 1.1.1.62) (Placental 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 1)	HSD17B1 E17KSR EDH17B1 EDH17B2 EDHB17 SDR28C1	Homo sapiens (Human)	328	FUNCTION: Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH. {ECO:0000269|PubMed:8994190}.		adipose tissue development [GO:0060612]; bone development [GO:0060348]; cellular response to metal ion [GO:0071248]; estrogen biosynthetic process [GO:0006703]; estrogen metabolic process [GO:0008210]; gene expression [GO:0010467]; lysosome organization [GO:0007040]; skeletal muscle tissue development [GO:0007519]; steroid biosynthetic process [GO:0006694]; testosterone biosynthetic process [GO:0061370]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	17-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0072582]; catalytic activity [GO:0003824]; dihydrotestosterone 17-beta-dehydrogenase activity [GO:0035410]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; estradiol binding [GO:1903924]; NADP binding [GO:0050661]; NADP+ binding [GO:0070401]; protein homodimerization activity [GO:0042803]; small molecule binding [GO:0036094]; steroid binding [GO:0005496]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; testosterone dehydrogenase [NAD(P)] activity [GO:0030283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; 17-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0072582]; catalytic activity [GO:0003824]; dihydrotestosterone 17-beta-dehydrogenase activity [GO:0035410]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; estradiol binding [GO:1903924]; NADP binding [GO:0050661]; NADP+ binding [GO:0070401]; protein homodimerization activity [GO:0042803]; small molecule binding [GO:0036094]; steroid binding [GO:0005496]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; testosterone dehydrogenase [NAD(P)] activity [GO:0030283]; adipose tissue development [GO:0060612]; bone development [GO:0060348]; cellular response to metal ion [GO:0071248]; estrogen biosynthetic process [GO:0006703]; estrogen metabolic process [GO:0008210]; gene expression [GO:0010467]; lysosome organization [GO:0007040]; skeletal muscle tissue development [GO:0007519]; steroid biosynthetic process [GO:0006694]; testosterone biosynthetic process [GO:0061370]	SUBCELLULAR LOCATION: Cytoplasm.
P14091	reviewed	CATE_HUMAN	Cathepsin E (EC 3.4.23.34) [Cleaved into: Cathepsin E form I; Cathepsin E form II]	CTSE	Homo sapiens (Human)	396	FUNCTION: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. {ECO:0000269|PubMed:8765029}.	MISCELLANEOUS: [Isoform 3]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]	endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]	aspartic-type endopeptidase activity [GO:0004190]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]	endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; aspartic-type endopeptidase activity [GO:0004190]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:7983070}. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
P14136	reviewed	GFAP_HUMAN	Glial fibrillary acidic protein (GFAP)	GFAP	Homo sapiens (Human)	432	FUNCTION: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.		astrocyte development [GO:0014002]; Bergmann glial cell differentiation [GO:0060020]; D-aspartate import across plasma membrane [GO:0070779]; extracellular matrix organization [GO:0030198]; gene expression [GO:0010467]; intermediate filament organization [GO:0045109]; intracellular protein transport [GO:0006886]; long-term synaptic potentiation [GO:0060291]; negative regulation of neuron projection development [GO:0010977]; neuron projection regeneration [GO:0031102]; positive regulation of Schwann cell proliferation [GO:0010625]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of neurotransmitter uptake [GO:0051580]; regulation of protein-containing complex assembly [GO:0043254]; Schwann cell proliferation [GO:0014010]	astrocyte end-foot [GO:0097450]; cell body [GO:0044297]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]	identical protein binding [GO:0042802]; integrin binding [GO:0005178]; kinase binding [GO:0019900]; structural constituent of cytoskeleton [GO:0005200]	astrocyte end-foot [GO:0097450]; cell body [GO:0044297]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; kinase binding [GO:0019900]; structural constituent of cytoskeleton [GO:0005200]; astrocyte development [GO:0014002]; Bergmann glial cell differentiation [GO:0060020]; D-aspartate import across plasma membrane [GO:0070779]; extracellular matrix organization [GO:0030198]; gene expression [GO:0010467]; intermediate filament organization [GO:0045109]; intracellular protein transport [GO:0006886]; long-term synaptic potentiation [GO:0060291]; negative regulation of neuron projection development [GO:0010977]; neuron projection regeneration [GO:0031102]; positive regulation of Schwann cell proliferation [GO:0010625]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of neurotransmitter uptake [GO:0051580]; regulation of protein-containing complex assembly [GO:0043254]; Schwann cell proliferation [GO:0014010]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12058025}. Note=Associated with intermediate filaments. {ECO:0000269|PubMed:12058025}.
P14138	reviewed	EDN3_HUMAN	Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3)	EDN3	Homo sapiens (Human)	238	FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides.		axon extension [GO:0048675]; axon guidance [GO:0007411]; blood circulation [GO:0008015]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; establishment of localization in cell [GO:0051649]; inositol phosphate-mediated signaling [GO:0048016]; intracellular calcium ion homeostasis [GO:0006874]; intracellular magnesium ion homeostasis [GO:0010961]; melanocyte differentiation [GO:0030318]; neural crest cell migration [GO:0001755]; neutrophil chemotaxis [GO:0030593]; peptide hormone secretion [GO:0030072]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of heart rate [GO:0010460]; positive regulation of hormone secretion [GO:0046887]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transmembrane transport [GO:0071805]; regulation of developmental pigmentation [GO:0048070]; regulation of gene expression [GO:0010468]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; signal transduction [GO:0007165]; vasoconstriction [GO:0042310]; vein smooth muscle contraction [GO:0014826]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	endothelin B receptor binding [GO:0031708]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; endothelin B receptor binding [GO:0031708]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; axon extension [GO:0048675]; axon guidance [GO:0007411]; blood circulation [GO:0008015]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; establishment of localization in cell [GO:0051649]; inositol phosphate-mediated signaling [GO:0048016]; intracellular calcium ion homeostasis [GO:0006874]; intracellular magnesium ion homeostasis [GO:0010961]; melanocyte differentiation [GO:0030318]; neural crest cell migration [GO:0001755]; neutrophil chemotaxis [GO:0030593]; peptide hormone secretion [GO:0030072]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of heart rate [GO:0010460]; positive regulation of hormone secretion [GO:0046887]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transmembrane transport [GO:0071805]; regulation of developmental pigmentation [GO:0048070]; regulation of gene expression [GO:0010468]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; signal transduction [GO:0007165]; vasoconstriction [GO:0042310]; vein smooth muscle contraction [GO:0014826]	SUBCELLULAR LOCATION: Secreted.
P14151	reviewed	LYAM1_HUMAN	L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)	SELL LNHR LYAM1	Homo sapiens (Human)	372	FUNCTION: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641). {ECO:0000269|PubMed:12403782, ECO:0000269|PubMed:28011641, ECO:0000305|PubMed:28489325}.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; response to cytokine [GO:0034097]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; glycosphingolipid binding [GO:0043208]; heparin binding [GO:0008201]; oligosaccharide binding [GO:0070492]; protease binding [GO:0002020]; sialic acid binding [GO:0033691]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; glycosphingolipid binding [GO:0043208]; heparin binding [GO:0008201]; oligosaccharide binding [GO:0070492]; protease binding [GO:0002020]; sialic acid binding [GO:0033691]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; response to cytokine [GO:0034097]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2509939, ECO:0000269|PubMed:2663882, ECO:0000269|PubMed:28011641}; Single-pass type I membrane protein {ECO:0000305|PubMed:2663882}.
P14174	reviewed	MIF_HUMAN	Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase)	MIF GLIF MMIF	Homo sapiens (Human)	115	FUNCTION: Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens (PubMed:15908412, PubMed:17443469, PubMed:23776208). The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense (PubMed:15908412, PubMed:17443469, PubMed:23776208). Counteracts the anti-inflammatory activity of glucocorticoids (PubMed:15908412, PubMed:17443469, PubMed:23776208). Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known (PubMed:11439086, PubMed:17526494). It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (PubMed:11439086, PubMed:17526494). {ECO:0000269|PubMed:11439086, ECO:0000269|PubMed:15908412, ECO:0000269|PubMed:17443469, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:23776208}.	MISCELLANEOUS: Serum levels of MIF are elevated in patients with severe sepsis or septic shock. High levels of MIF are correlated with low survival. Drugs that inhibit tautomerase activity protect against death due to sepsis. {ECO:0000269|PubMed:17443469}.	carboxylic acid metabolic process [GO:0019752]; cell surface receptor signaling pathway [GO:0007166]; cellular senescence [GO:0090398]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of macrophage chemotaxis [GO:0010760]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of protein metabolic process [GO:0051248]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of myeloid leukocyte cytokine production involved in immune response [GO:0061081]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphorylation [GO:0042327]; positive regulation of prostaglandin secretion involved in immune response [GO:0061078]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of tumor necrosis factor production [GO:0032760]; prostaglandin biosynthetic process [GO:0001516]; protein homotrimerization [GO:0070207]; regulation of macrophage activation [GO:0043030]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982]	chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; dopachrome isomerase activity [GO:0004167]; identical protein binding [GO:0042802]; phenylpyruvate tautomerase activity [GO:0050178]; protease binding [GO:0002020]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982]; chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; dopachrome isomerase activity [GO:0004167]; identical protein binding [GO:0042802]; phenylpyruvate tautomerase activity [GO:0050178]; protease binding [GO:0002020]; carboxylic acid metabolic process [GO:0019752]; cell surface receptor signaling pathway [GO:0007166]; cellular senescence [GO:0090398]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of macrophage chemotaxis [GO:0010760]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of protein metabolic process [GO:0051248]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of myeloid leukocyte cytokine production involved in immune response [GO:0061081]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphorylation [GO:0042327]; positive regulation of prostaglandin secretion involved in immune response [GO:0061078]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of tumor necrosis factor production [GO:0032760]; prostaglandin biosynthetic process [GO:0001516]; protein homotrimerization [GO:0070207]; regulation of macrophage activation [GO:0043030]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15908412, ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:2552447, ECO:0000269|PubMed:8234256}. Cytoplasm {ECO:0000269|PubMed:11089976, ECO:0000269|PubMed:19454686}. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. {ECO:0000269|PubMed:15908412}.
P14207	reviewed	FOLR2_HUMAN	Folate receptor beta (FR-beta) (Folate receptor 2) (Folate receptor, fetal/placental) (Placental folate-binding protein) (FBP)	FOLR2	Homo sapiens (Human)	255	FUNCTION: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. {ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:4066659}.		cell adhesion [GO:0007155]; folic acid transport [GO:0015884]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; inflammatory response [GO:0006954]; positive regulation of cell population proliferation [GO:0008284]; sperm-egg recognition [GO:0035036]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	folic acid binding [GO:0005542]; folic acid receptor activity [GO:0061714]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; folic acid binding [GO:0005542]; folic acid receptor activity [GO:0061714]; signaling receptor activity [GO:0038023]; cell adhesion [GO:0007155]; folic acid transport [GO:0015884]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; inflammatory response [GO:0006954]; positive regulation of cell population proliferation [GO:0008284]; sperm-egg recognition [GO:0035036]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}.
P14209	reviewed	CD99_HUMAN	CD99 antigen (12E7) (E2 antigen) (Protein MIC2) (T-cell surface glycoprotein E2) (CD antigen CD99)	CD99 MIC2 MIC2X MIC2Y	Homo sapiens (Human)	185	FUNCTION: Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity). {ECO:0000250}.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.	homotypic cell-cell adhesion [GO:0034109]; positive regulation of neutrophil extravasation [GO:2000391]; T cell extravasation [GO:0072683]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; homotypic cell-cell adhesion [GO:0034109]; positive regulation of neutrophil extravasation [GO:2000391]; T cell extravasation [GO:0072683]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
P14210	reviewed	HGF_HUMAN	Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]	HGF HPTA	Homo sapiens (Human)	728	FUNCTION: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (PubMed:20977675, PubMed:15167892). Activates MAPK signaling following TMPRSS13 cleavage and activation (PubMed:20977675). {ECO:0000269|PubMed:15167892, ECO:0000269|PubMed:20624990, ECO:0000269|PubMed:20977675}.	MISCELLANEOUS: [Isoform 4]: Acts as a competitive antagonist in MET-signaling. {ECO:0000305}.	cell chemotaxis [GO:0060326]; cell morphogenesis [GO:0000902]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; liver development [GO:0001889]; mitotic cell cycle [GO:0000278]; myoblast proliferation [GO:0051450]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of p38MAPK cascade [GO:1900744]; skeletal muscle cell proliferation [GO:0014856]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]	chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; cell chemotaxis [GO:0060326]; cell morphogenesis [GO:0000902]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; liver development [GO:0001889]; mitotic cell cycle [GO:0000278]; myoblast proliferation [GO:0051450]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of p38MAPK cascade [GO:1900744]; skeletal muscle cell proliferation [GO:0014856]	
P14222	reviewed	PERF_HUMAN	Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)	PRF1 PFP	Homo sapiens (Human)	555	FUNCTION: Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells (PubMed:9058810, PubMed:9164947, PubMed:20889983, PubMed:24558045, PubMed:21037563). Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease (PubMed:9058810). Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores (PubMed:20889983, PubMed:21037563). Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes (PubMed:20038786, PubMed:20225066, PubMed:24558045, PubMed:32299851). Facilitates the delivery of cationic cargo protein, while anionic or neural proteins are not delivered efficiently (PubMed:24558045). Perforin pores allow the release of mature caspase-7 (CASP7) into the extracellular milieu (By similarity). {ECO:0000250|UniProtKB:P10820, ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:20225066, ECO:0000269|PubMed:20889983, ECO:0000269|PubMed:21037563, ECO:0000269|PubMed:24558045, ECO:0000269|PubMed:32299851, ECO:0000269|PubMed:9058810, ECO:0000269|PubMed:9164947}.		apoptotic process [GO:0006915]; cellular defense response [GO:0006968]; defense response to tumor cell [GO:0002357]; defense response to virus [GO:0051607]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; immune response to tumor cell [GO:0002418]; immunological synapse formation [GO:0001771]; killing of cells of another organism [GO:0031640]; positive regulation of killing of cells of another organism [GO:0051712]; protein homooligomerization [GO:0051260]; protein import [GO:0017038]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; T cell mediated cytotoxicity [GO:0001913]	cytolytic granule [GO:0044194]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; pore-forming activity [GO:0140911]; wide pore channel activity [GO:0022829]	cytolytic granule [GO:0044194]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; pore-forming activity [GO:0140911]; wide pore channel activity [GO:0022829]; apoptotic process [GO:0006915]; cellular defense response [GO:0006968]; defense response to tumor cell [GO:0002357]; defense response to virus [GO:0051607]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; immune response to tumor cell [GO:0002418]; immunological synapse formation [GO:0001771]; killing of cells of another organism [GO:0031640]; positive regulation of killing of cells of another organism [GO:0051712]; protein homooligomerization [GO:0051260]; protein import [GO:0017038]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; T cell mediated cytotoxicity [GO:0001913]	SUBCELLULAR LOCATION: Cytolytic granule {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:24088571}. Secreted. Cell membrane {ECO:0000269|PubMed:20889983, ECO:0000269|PubMed:21037563}; Multi-pass membrane protein {ECO:0000269|PubMed:20889983, ECO:0000269|PubMed:21037563}. Endosome lumen {ECO:0000269|PubMed:20038786}. Note=Stored in cytolytic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell (PubMed:20038786). Inserts into the cell membrane of target cells and forms pores (PubMed:20889983). Membrane insertion and pore formation requires a major conformation change (PubMed:20889983). May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes (PubMed:20038786). {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:20889983}.
P14314	reviewed	GLU2B_HUMAN	Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH)	PRKCSH G19P1	Homo sapiens (Human)	528	FUNCTION: Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}.		intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; N-glycan processing [GO:0006491]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; glucosidase II complex [GO:0017177]; intracellular membrane-bounded organelle [GO:0043231]	calcium ion binding [GO:0005509]; phosphoprotein binding [GO:0051219]; protein kinase C binding [GO:0005080]; transmembrane transporter binding [GO:0044325]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; glucosidase II complex [GO:0017177]; intracellular membrane-bounded organelle [GO:0043231]; calcium ion binding [GO:0005509]; phosphoprotein binding [GO:0051219]; protein kinase C binding [GO:0005080]; transmembrane transporter binding [GO:0044325]; intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; N-glycan processing [GO:0006491]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000305|PubMed:10929008}.
P14316	reviewed	IRF2_HUMAN	Interferon regulatory factor 2 (IRF-2)	IRF2	Homo sapiens (Human)	349	FUNCTION: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. {ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}.	MISCELLANEOUS: [Isoform 2]: Unable to bind to IRF2BP1 and IRF2BP2 corepressors and cannot mediate repression. {ECO:0000305}.	cell population proliferation [GO:0008283]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; cell population proliferation [GO:0008283]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P14317	reviewed	HCLS1_HUMAN	Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75)	HCLS1 HS1	Homo sapiens (Human)	486	FUNCTION: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.		actin filament organization [GO:0007015]; cellular response to cytokine stimulus [GO:0071345]; erythrocyte differentiation [GO:0030218]; intracellular signal transduction [GO:0035556]; negative regulation of leukocyte apoptotic process [GO:2000107]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of actin filament polymerization [GO:0030833]; regulation of DNA-templated transcription [GO:0006355]; response to hormone [GO:0009725]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]	actin filament binding [GO:0051015]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]; actin filament binding [GO:0051015]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SH3 domain binding [GO:0017124]; actin filament organization [GO:0007015]; cellular response to cytokine stimulus [GO:0071345]; erythrocyte differentiation [GO:0030218]; intracellular signal transduction [GO:0035556]; negative regulation of leukocyte apoptotic process [GO:2000107]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of actin filament polymerization [GO:0030833]; regulation of DNA-templated transcription [GO:0006355]; response to hormone [GO:0009725]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:7682714}; Peripheral membrane protein {ECO:0000269|PubMed:7682714}. Cytoplasm {ECO:0000269|PubMed:7682714}. Mitochondrion {ECO:0000305|PubMed:7682714}.
P14324	reviewed	FPPS_HUMAN	Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase)	FDPS FPS KIAA1293	Homo sapiens (Human)	419	FUNCTION: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.		cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	dimethylallyltranstransferase activity [GO:0004161]; geranyltranstransferase activity [GO:0004337]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; dimethylallyltranstransferase activity [GO:0004161]; geranyltranstransferase activity [GO:0004337]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384]	SUBCELLULAR LOCATION: Cytoplasm.
P14373	reviewed	TRI27_HUMAN	Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27)	TRIM27 RFP RNF76	Homo sapiens (Human)	513	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:22829933, PubMed:24144979, PubMed:29688809, PubMed:36111389). Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. Forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-alpha-induced apoptosis (PubMed:24144979). In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation (PubMed:26358190, PubMed:29688809). Acts as a negative regulator of NOD2 signaling by mediating ubiquitination of NOD2, promoting its degradation by the proteasome (PubMed:22829933). Alternatively, facilitates mitophagy via stabilization of active TBK1 (PubMed:36111389). Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1 (PubMed:35670107). During starvation-induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy (PubMed:35670107). {ECO:0000269|PubMed:10976108, ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329, ECO:0000269|PubMed:22829933, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:26358190, ECO:0000269|PubMed:29688809, ECO:0000269|PubMed:35670107, ECO:0000269|PubMed:36111389}.; FUNCTION: (Microbial infection) Positively regulates hepatitis C virus replication by suppressing type I IFN response during infection. {ECO:0000269|PubMed:29688809}.		Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of autophagy [GO:0010507]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon production [GO:0032480]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of type II interferon production [GO:0032729]; protein K63-linked ubiquitination [GO:0070534]; protein sumoylation [GO:0016925]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]; suppression of viral release by host [GO:0044790]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of autophagy [GO:0010507]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon production [GO:0032480]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of type II interferon production [GO:0032729]; protein K63-linked ubiquitination [GO:0070534]; protein sumoylation [GO:0016925]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]; suppression of viral release by host [GO:0044790]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17156811}. Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:36111389}. Nucleus, PML body {ECO:0000250}. Early endosome {ECO:0000269|PubMed:1437549, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:9247190}. Mitochondrion {ECO:0000269|PubMed:24144979}. Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). Co-localizes with p62/SQSTM1 and TBK1 in cytoplasmic structures that are closely associated with the mitochondria (PubMed:36111389). {ECO:0000250, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:36111389}.
P14384	reviewed	CBPM_HUMAN	Carboxypeptidase M (CPM) (EC 3.4.17.12)	CPM	Homo sapiens (Human)	443	FUNCTION: Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. {ECO:0000269|PubMed:12457462}.		anatomical structure morphogenesis [GO:0009653]; peptide metabolic process [GO:0006518]; protein processing [GO:0016485]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	carboxypeptidase activity [GO:0004180]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; carboxypeptidase activity [GO:0004180]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; anatomical structure morphogenesis [GO:0009653]; peptide metabolic process [GO:0006518]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12457462}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12457462}.
P14406	reviewed	CX7A2_HUMAN	Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L) (Cytochrome c oxidase subunit VIIaL)	COX7A2 COX7AL	Homo sapiens (Human)	83	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10174}.		cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]	mitochondrial membrane [GO:0031966]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex IV [GO:0005751]	oxidoreductase activity [GO:0016491]	mitochondrial membrane [GO:0031966]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex IV [GO:0005751]; oxidoreductase activity [GO:0016491]; cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
P14410	reviewed	SUIS_HUMAN	Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]	SI	Homo sapiens (Human)	1827	FUNCTION: Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides. {ECO:0000269|PubMed:20356844}.	MISCELLANEOUS: There is a high degree of homology between the isomaltase and sucrase portions (41% of amino acid identity) indicating that this protein is evolved by partial gene duplication.	polysaccharide digestion [GO:0044245]; sucrose catabolic process [GO:0005987]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]; oligo-1,6-glucosidase activity [GO:0004574]; sucrose alpha-glucosidase activity [GO:0004575]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]; oligo-1,6-glucosidase activity [GO:0004574]; sucrose alpha-glucosidase activity [GO:0004575]; polysaccharide digestion [GO:0044245]; sucrose catabolic process [GO:0005987]	SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type II membrane protein. Note=Brush border.
P14415	reviewed	AT1B2_HUMAN	Sodium/potassium-transporting ATPase subunit beta-2 (Adhesion molecule in glia) (AMOG) (Sodium/potassium-dependent ATPase subunit beta-2)	ATP1B2	Homo sapiens (Human)	290	FUNCTION: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.; FUNCTION: Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth. {ECO:0000250}.		cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-substrate adhesion [GO:0031589]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; lateral ventricle development [GO:0021670]; membrane repolarization [GO:0086009]; motor behavior [GO:0061744]; negative regulation of glial cell migration [GO:1903976]; neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration [GO:0021944]; photoreceptor cell maintenance [GO:0045494]; plasma membrane bounded cell projection organization [GO:0120036]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of neuron projection development [GO:0010976]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion import across plasma membrane [GO:1990573]; protein stabilization [GO:0050821]; retina homeostasis [GO:0001895]; sodium ion export across plasma membrane [GO:0036376]; third ventricle development [GO:0021678]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; astrocyte projection [GO:0097449]; cell body membrane [GO:0044298]; cell periphery [GO:0071944]; cell projection membrane [GO:0031253]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron to neuron synapse [GO:0098984]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]	ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674]	apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; astrocyte projection [GO:0097449]; cell body membrane [GO:0044298]; cell periphery [GO:0071944]; cell projection membrane [GO:0031253]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron to neuron synapse [GO:0098984]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-substrate adhesion [GO:0031589]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; lateral ventricle development [GO:0021670]; membrane repolarization [GO:0086009]; motor behavior [GO:0061744]; negative regulation of glial cell migration [GO:1903976]; neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration [GO:0021944]; photoreceptor cell maintenance [GO:0045494]; plasma membrane bounded cell projection organization [GO:0120036]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of neuron projection development [GO:0010976]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion import across plasma membrane [GO:1990573]; protein stabilization [GO:0050821]; retina homeostasis [GO:0001895]; sodium ion export across plasma membrane [GO:0036376]; third ventricle development [GO:0021678]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.
P14416	reviewed	DRD2_HUMAN	D(2) dopamine receptor (Dopamine D2 receptor)	DRD2	Homo sapiens (Human)	443	FUNCTION: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). {ECO:0000250|UniProtKB:P61168, ECO:0000269|PubMed:21645528}.		acid secretion [GO:0046717]; adenohypophysis development [GO:0021984]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; adult walking behavior [GO:0007628]; arachidonic acid secretion [GO:0050482]; associative learning [GO:0008306]; auditory behavior [GO:0031223]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; behavioral response to cocaine [GO:0048148]; behavioral response to ethanol [GO:0048149]; branching morphogenesis of a nerve [GO:0048755]; cerebral cortex GABAergic interneuron migration [GO:0021853]; circadian regulation of gene expression [GO:0032922]; dopamine metabolic process [GO:0042417]; dopamine uptake involved in synaptic transmission [GO:0051583]; drinking behavior [GO:0042756]; epithelial cell proliferation [GO:0050673]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled receptor internalization [GO:0002031]; grooming behavior [GO:0007625]; hyaloid vascular plexus regression [GO:1990384]; intracellular calcium ion homeostasis [GO:0006874]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of circadian sleep/wake cycle, sleep [GO:0042321]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of dopamine receptor signaling pathway [GO:0060160]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of innate immune response [GO:0045824]; negative regulation of insulin secretion [GO:0046676]; negative regulation of neuron migration [GO:2001223]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein secretion [GO:0050709]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; nervous system process involved in regulation of systemic arterial blood pressure [GO:0001976]; neuroblast proliferation [GO:0007405]; neuron-neuron synaptic transmission [GO:0007270]; orbitofrontal cortex development [GO:0021769]; peristalsis [GO:0030432]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; pigmentation [GO:0043473]; positive regulation of cytokinesis [GO:0032467]; positive regulation of dopamine uptake involved in synaptic transmission [GO:0051586]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of glial cell-derived neurotrophic factor production [GO:1900168]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of receptor internalization [GO:0002092]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of urine volume [GO:0035810]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein localization [GO:0008104]; regulation of dopamine secretion [GO:0014059]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of heart rate [GO:0002027]; regulation of locomotion involved in locomotory behavior [GO:0090325]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of potassium ion transport [GO:0043266]; regulation of sodium ion transport [GO:0002028]; regulation of synapse structural plasticity [GO:0051823]; regulation of synaptic transmission, GABAergic [GO:0032228]; release of sequestered calcium ion into cytosol [GO:0051209]; response to amphetamine [GO:0001975]; response to axon injury [GO:0048678]; response to cocaine [GO:0042220]; response to histamine [GO:0034776]; response to hypoxia [GO:0001666]; response to inactivity [GO:0014854]; response to iron ion [GO:0010039]; response to light stimulus [GO:0009416]; response to morphine [GO:0043278]; response to nicotine [GO:0035094]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; sensory perception of smell [GO:0007608]; striatum development [GO:0021756]; synapse assembly [GO:0007416]; temperature homeostasis [GO:0001659]; visual learning [GO:0008542]; Wnt signaling pathway [GO:0016055]	acrosomal vesicle [GO:0001669]; axon [GO:0030424]; axon terminus [GO:0043679]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; dopaminergic synapse [GO:0098691]; endocytic vesicle [GO:0030139]; G protein-coupled receptor complex [GO:0097648]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; lateral plasma membrane [GO:0016328]; non-motile cilium [GO:0097730]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; sperm flagellum [GO:0036126]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]	dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; heterocyclic compound binding [GO:1901363]; heterotrimeric G-protein binding [GO:0032795]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; potassium channel regulator activity [GO:0015459]	acrosomal vesicle [GO:0001669]; axon [GO:0030424]; axon terminus [GO:0043679]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; dopaminergic synapse [GO:0098691]; endocytic vesicle [GO:0030139]; G protein-coupled receptor complex [GO:0097648]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; lateral plasma membrane [GO:0016328]; non-motile cilium [GO:0097730]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; sperm flagellum [GO:0036126]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]; dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; heterocyclic compound binding [GO:1901363]; heterotrimeric G-protein binding [GO:0032795]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; potassium channel regulator activity [GO:0015459]; acid secretion [GO:0046717]; adenohypophysis development [GO:0021984]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; adult walking behavior [GO:0007628]; arachidonic acid secretion [GO:0050482]; associative learning [GO:0008306]; auditory behavior [GO:0031223]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; behavioral response to cocaine [GO:0048148]; behavioral response to ethanol [GO:0048149]; branching morphogenesis of a nerve [GO:0048755]; cerebral cortex GABAergic interneuron migration [GO:0021853]; circadian regulation of gene expression [GO:0032922]; dopamine metabolic process [GO:0042417]; dopamine uptake involved in synaptic transmission [GO:0051583]; drinking behavior [GO:0042756]; epithelial cell proliferation [GO:0050673]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled receptor internalization [GO:0002031]; grooming behavior [GO:0007625]; hyaloid vascular plexus regression [GO:1990384]; intracellular calcium ion homeostasis [GO:0006874]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of circadian sleep/wake cycle, sleep [GO:0042321]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of dopamine receptor signaling pathway [GO:0060160]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of innate immune response [GO:0045824]; negative regulation of insulin secretion [GO:0046676]; negative regulation of neuron migration [GO:2001223]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein secretion [GO:0050709]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; nervous system process involved in regulation of systemic arterial blood pressure [GO:0001976]; neuroblast proliferation [GO:0007405]; neuron-neuron synaptic transmission [GO:0007270]; orbitofrontal cortex development [GO:0021769]; peristalsis [GO:0030432]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; pigmentation [GO:0043473]; positive regulation of cytokinesis [GO:0032467]; positive regulation of dopamine uptake involved in synaptic transmission [GO:0051586]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of glial cell-derived neurotrophic factor production [GO:1900168]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of receptor internalization [GO:0002092]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of urine volume [GO:0035810]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein localization [GO:0008104]; regulation of dopamine secretion [GO:0014059]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of heart rate [GO:0002027]; regulation of locomotion involved in locomotory behavior [GO:0090325]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of potassium ion transport [GO:0043266]; regulation of sodium ion transport [GO:0002028]; regulation of synapse structural plasticity [GO:0051823]; regulation of synaptic transmission, GABAergic [GO:0032228]; release of sequestered calcium ion into cytosol [GO:0051209]; response to amphetamine [GO:0001975]; response to axon injury [GO:0048678]; response to cocaine [GO:0042220]; response to histamine [GO:0034776]; response to hypoxia [GO:0001666]; response to inactivity [GO:0014854]; response to iron ion [GO:0010039]; response to light stimulus [GO:0009416]; response to morphine [GO:0043278]; response to nicotine [GO:0035094]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; sensory perception of smell [GO:0007608]; striatum development [GO:0021756]; synapse assembly [GO:0007416]; temperature homeostasis [GO:0001659]; visual learning [GO:0008542]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21645528, ECO:0000269|PubMed:26535572}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:26535572}; Multi-pass membrane protein {ECO:0000255}.
P14543	reviewed	NID1_HUMAN	Nidogen-1 (NID-1) (Entactin)	NID1 NID	Homo sapiens (Human)	1247	FUNCTION: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.		basement membrane organization [GO:0071711]; canonical Wnt signaling pathway [GO:0060070]; cell-matrix adhesion [GO:0007160]; glomerular basement membrane development [GO:0032836]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; protein complex involved in cell-matrix adhesion [GO:0098637]	calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; laminin binding [GO:0043236]; laminin-1 binding [GO:0043237]; proteoglycan binding [GO:0043394]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; protein complex involved in cell-matrix adhesion [GO:0098637]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; laminin binding [GO:0043236]; laminin-1 binding [GO:0043237]; proteoglycan binding [GO:0043394]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; basement membrane organization [GO:0071711]; canonical Wnt signaling pathway [GO:0060070]; cell-matrix adhesion [GO:0007160]; glomerular basement membrane development [GO:0032836]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
P14550	reviewed	AK1A1_HUMAN	Aldo-keto reductase family 1 member A1 (EC 1.1.1.2) (EC 1.1.1.372) (EC 1.1.1.54) (Alcohol dehydrogenase [NADP(+)]) (Aldehyde reductase) (Glucuronate reductase) (EC 1.1.1.19) (Glucuronolactone reductase) (EC 1.1.1.20)	AKR1A1 ALDR1 ALR	Homo sapiens (Human)	325	FUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:18276838, PubMed:11306097). Displays no reductase activity towards retinoids (By similarity). {ECO:0000250|UniProtKB:P50578, ECO:0000250|UniProtKB:P51635, ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:11306097, ECO:0000269|PubMed:18276838}.		aldehyde catabolic process [GO:0046185]; cellular detoxification of aldehyde [GO:0110095]; D-glucuronate catabolic process [GO:0042840]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; glutathione derivative biosynthetic process [GO:1901687]; L-ascorbic acid biosynthetic process [GO:0019853]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; synapse [GO:0045202]	alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; allyl-alcohol dehydrogenase activity [GO:0047655]; glucuronolactone reductase activity [GO:0047941]; glycerol dehydrogenase [NADP+] activity [GO:0047956]; L-glucuronate reductase activity [GO:0047939]; methylglyoxal reductase (NADPH-dependent, acetol producing) [GO:1990002]; oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [GO:0016657]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; synapse [GO:0045202]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; allyl-alcohol dehydrogenase activity [GO:0047655]; glucuronolactone reductase activity [GO:0047941]; glycerol dehydrogenase [NADP+] activity [GO:0047956]; L-glucuronate reductase activity [GO:0047939]; methylglyoxal reductase (NADPH-dependent, acetol producing) [GO:1990002]; oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [GO:0016657]; aldehyde catabolic process [GO:0046185]; cellular detoxification of aldehyde [GO:0110095]; D-glucuronate catabolic process [GO:0042840]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; glutathione derivative biosynthetic process [GO:1901687]; L-ascorbic acid biosynthetic process [GO:0019853]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JII6}. Apical cell membrane {ECO:0000250|UniProtKB:Q9JII6}.
P14555	reviewed	PA2GA_HUMAN	Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Non-pancreatic secretory phospholipase A2) (NPS-PLA2) (Phosphatidylcholine 2-acylhydrolase 2A)	PLA2G2A PLA2B PLA2L RASF-A	Homo sapiens (Human)	144	FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (PubMed:10455175, PubMed:10681567, PubMed:2925633). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10455175, PubMed:10681567). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541, PubMed:10358193). Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (PubMed:25082876). Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370). Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536). {ECO:0000250|UniProtKB:P31482, ECO:0000269|PubMed:10358193, ECO:0000269|PubMed:10455175, ECO:0000269|PubMed:10681567, ECO:0000269|PubMed:11694541, ECO:0000269|PubMed:14998370, ECO:0000269|PubMed:25082876, ECO:0000269|PubMed:2925633}.	MISCELLANEOUS: Group II phospholipase A2 is found in many cells and also extracellularly. The membrane-bound and secreted forms are identical and are encoded by a single gene.; MISCELLANEOUS: Interaction with integrin ITGA4:ITGB3 is inhibited by a number of synthetic peptides including R-Ala-Trp-Asp-Ile and R-Gly-Arg-Gly-Asp-Asp-Asp which bind to PLA2G2A and disrupt its integrin-binding activity. {ECO:0000269|PubMed:23164706}.	arachidonic acid secretion [GO:0050482]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; intestinal stem cell homeostasis [GO:0036335]; killing of cells of another organism [GO:0031640]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of T cell proliferation [GO:0042130]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phospholipid metabolic process [GO:0006644]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; regulation of neutrophil activation [GO:1902563]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543]; arachidonic acid secretion [GO:0050482]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; intestinal stem cell homeostasis [GO:0036335]; killing of cells of another organism [GO:0031640]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of T cell proliferation [GO:0042130]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phospholipid metabolic process [GO:0006644]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; regulation of neutrophil activation [GO:1902563]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2925608, ECO:0000269|PubMed:2925633}. Cell membrane {ECO:0000269|PubMed:2775276}; Peripheral membrane protein {ECO:0000305}. Mitochondrion outer membrane {ECO:0000269|PubMed:25082876}; Peripheral membrane protein {ECO:0000305}.
P14598	reviewed	NCF1_HUMAN	Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)	NCF1 NOXO2 SH3PXD1A	Homo sapiens (Human)	390	FUNCTION: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933}.	MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.	cellular defense response [GO:0006968]; cellular response to cadmium ion [GO:0071276]; cellular response to glucose stimulus [GO:0071333]; cellular response to reactive oxygen species [GO:0034614]; cellular response to testosterone stimulus [GO:0071394]; innate immune response [GO:0045087]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein targeting to membrane [GO:0006612]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of respiratory burst involved in inflammatory response [GO:0060264]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; neuronal cell body [GO:0043025]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]	electron transfer activity [GO:0009055]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; SH3 domain binding [GO:0017124]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activator activity [GO:0016176]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; neuronal cell body [GO:0043025]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; SH3 domain binding [GO:0017124]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; cellular defense response [GO:0006968]; cellular response to cadmium ion [GO:0071276]; cellular response to glucose stimulus [GO:0071333]; cellular response to reactive oxygen species [GO:0034614]; cellular response to testosterone stimulus [GO:0071394]; innate immune response [GO:0045087]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein targeting to membrane [GO:0006612]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of respiratory burst involved in inflammatory response [GO:0060264]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:2550933}. Membrane {ECO:0000269|PubMed:12356722}; Peripheral membrane protein {ECO:0000269|PubMed:12356722}; Cytoplasmic side {ECO:0000269|PubMed:12356722}.
P14616	reviewed	INSRR_HUMAN	Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]	INSRR IRR	Homo sapiens (Human)	1297	FUNCTION: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. {ECO:0000269|PubMed:21641549}.		actin cytoskeleton organization [GO:0030036]; cellular response to alkaline pH [GO:0071469]; male sex determination [GO:0030238]; protein autophosphorylation [GO:0046777]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	axon [GO:0030424]; insulin receptor complex [GO:0005899]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; insulin receptor activity [GO:0005009]; insulin receptor substrate binding [GO:0043560]; phosphatidylinositol 3-kinase binding [GO:0043548]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	axon [GO:0030424]; insulin receptor complex [GO:0005899]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; insulin receptor activity [GO:0005009]; insulin receptor substrate binding [GO:0043560]; phosphatidylinositol 3-kinase binding [GO:0043548]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; actin cytoskeleton organization [GO:0030036]; cellular response to alkaline pH [GO:0071469]; male sex determination [GO:0030238]; protein autophosphorylation [GO:0046777]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P14618	reviewed	KPYM_HUMAN	Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58)	PKM OIP3 PK2 PK3 PKM2	Homo sapiens (Human)	531	FUNCTION: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:20847263, PubMed:15996096, PubMed:1854723). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:20847263, PubMed:15996096, PubMed:1854723). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:20847263, PubMed:15996096, PubMed:1854723). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}.	MISCELLANEOUS: There are 4 isozymes of pyruvate kinase in mammals (L, R, M1, M2) encoded by 2 different genes: PKLR and PKM. The L and R isozymes are generated from the PKLR by differential splicing of RNA; the M1 and M2 forms are produced from the PKM gene by differential splicing. L type is major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues as well as in most cancer cells.	canonical glycolysis [GO:0061621]; cellular response to insulin stimulus [GO:0032869]; glycolytic process [GO:0006096]; phosphorylation [GO:0016310]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; programmed cell death [GO:0012501]	cilium [GO:0005929]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; rough endoplasmic reticulum [GO:0005791]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; histone H3T11 kinase activity [GO:0035402]; magnesium ion binding [GO:0000287]; MHC class II protein complex binding [GO:0023026]; mRNA binding [GO:0003729]; potassium ion binding [GO:0030955]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; pyruvate kinase activity [GO:0004743]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	cilium [GO:0005929]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; rough endoplasmic reticulum [GO:0005791]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; histone H3T11 kinase activity [GO:0035402]; magnesium ion binding [GO:0000287]; MHC class II protein complex binding [GO:0023026]; mRNA binding [GO:0003729]; potassium ion binding [GO:0030955]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; pyruvate kinase activity [GO:0004743]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; canonical glycolysis [GO:0061621]; cellular response to insulin stimulus [GO:0032869]; glycolytic process [GO:0006096]; phosphorylation [GO:0016310]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; programmed cell death [GO:0012501]	SUBCELLULAR LOCATION: [Isoform M2]: Cytoplasm {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352, ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352, ECO:0000269|PubMed:32268273}. Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylation by EP300 (PubMed:24120661). Deacetylation by SIRT6 promotes its nuclear export in a process dependent of XPO4, thereby suppressing its ability to activate transcription and promote tumorigenesis (PubMed:26787900). {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; SUBCELLULAR LOCATION: [Isoform M1]: Cytoplasm {ECO:0000305}.
P14625	reviewed	ENPL_HUMAN	Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog)	HSP90B1 GRP94 TRA1	Homo sapiens (Human)	803	FUNCTION: Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000250|UniProtKB:P08113, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:32272059}.		actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; cellular response to manganese ion [GO:0071287]; negative regulation of apoptotic process [GO:0043066]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein transport [GO:0015031]; regulation of phosphoprotein phosphatase activity [GO:0043666]; response to endoplasmic reticulum stress [GO:0034976]; response to hypoxia [GO:0001666]; retrograde protein transport, ER to cytosol [GO:0030970]; sequestering of calcium ion [GO:0051208]; ubiquitin-dependent ERAD pathway [GO:0030433]	collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790]; sperm plasma membrane [GO:0097524]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; calcium ion binding [GO:0005509]; low-density lipoprotein particle receptor binding [GO:0050750]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]	collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790]; sperm plasma membrane [GO:0097524]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; calcium ion binding [GO:0005509]; low-density lipoprotein particle receptor binding [GO:0050750]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; cellular response to manganese ion [GO:0071287]; negative regulation of apoptotic process [GO:0043066]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein transport [GO:0015031]; regulation of phosphoprotein phosphatase activity [GO:0043666]; response to endoplasmic reticulum stress [GO:0034976]; response to hypoxia [GO:0001666]; retrograde protein transport, ER to cytosol [GO:0030970]; sequestering of calcium ion [GO:0051208]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000305|PubMed:12475965}. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P41148}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}.
P14635	reviewed	CCNB1_HUMAN	G2/mitotic-specific cyclin-B1	CCNB1 CCNB	Homo sapiens (Human)	433	FUNCTION: Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533}.		cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; in utero embryonic development [GO:0001701]; mitotic cell cycle phase transition [GO:0044772]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	centrosome [GO:0005813]; cyclin B1-CDK1 complex [GO:0097125]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; patched binding [GO:0005113]; protein kinase binding [GO:0019901]; ubiquitin-like protein ligase binding [GO:0044389]	centrosome [GO:0005813]; cyclin B1-CDK1 complex [GO:0097125]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; patched binding [GO:0005113]; protein kinase binding [GO:0019901]; ubiquitin-like protein ligase binding [GO:0044389]; cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; in utero embryonic development [GO:0001701]; mitotic cell cycle phase transition [GO:0044772]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
P14649	reviewed	MYL6B_HUMAN	Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B)	MYL6B MLC1SA	Homo sapiens (Human)	208	FUNCTION: Regulatory light chain of myosin. Does not bind calcium.		muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle tissue development [GO:0007519]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle myosin complex [GO:0005859]; myosin complex [GO:0016459]; myosin II complex [GO:0016460]; unconventional myosin complex [GO:0016461]	calcium ion binding [GO:0005509]; cytoskeletal motor activity [GO:0003774]; structural constituent of muscle [GO:0008307]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle myosin complex [GO:0005859]; myosin complex [GO:0016459]; myosin II complex [GO:0016460]; unconventional myosin complex [GO:0016461]; calcium ion binding [GO:0005509]; cytoskeletal motor activity [GO:0003774]; structural constituent of muscle [GO:0008307]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle tissue development [GO:0007519]	
P14651	reviewed	HXB3_HUMAN	Homeobox protein Hox-B3 (Homeobox protein Hox-2.7) (Homeobox protein Hox-2G)	HOXB3 HOX2G	Homo sapiens (Human)	431	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; cartilage development [GO:0051216]; definitive hemopoiesis [GO:0060216]; embryonic skeletal system morphogenesis [GO:0048704]; face development [GO:0060324]; glossopharyngeal nerve morphogenesis [GO:0021615]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; rhombomere development [GO:0021546]; thyroid gland development [GO:0030878]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; cartilage development [GO:0051216]; definitive hemopoiesis [GO:0060216]; embryonic skeletal system morphogenesis [GO:0048704]; face development [GO:0060324]; glossopharyngeal nerve morphogenesis [GO:0021615]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; rhombomere development [GO:0021546]; thyroid gland development [GO:0030878]	SUBCELLULAR LOCATION: Nucleus.
P14652	reviewed	HXB2_HUMAN	Homeobox protein Hox-B2 (Homeobox protein Hox-2.8) (Homeobox protein Hox-2H) (K8)	HOXB2 HOX2H	Homo sapiens (Human)	356	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. {ECO:0000269|PubMed:10595394}.		anterior/posterior pattern specification [GO:0009952]; dorsal/ventral pattern formation [GO:0009953]; embryonic skeletal system morphogenesis [GO:0048704]; facial nerve structural organization [GO:0021612]; morphogenesis of an epithelial sheet [GO:0002011]; nervous system development [GO:0007399]; neural nucleus development [GO:0048857]; positive regulation of transcription by RNA polymerase II [GO:0045944]; rhombomere 3 development [GO:0021569]; rhombomere 4 development [GO:0021570]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; dorsal/ventral pattern formation [GO:0009953]; embryonic skeletal system morphogenesis [GO:0048704]; facial nerve structural organization [GO:0021612]; morphogenesis of an epithelial sheet [GO:0002011]; nervous system development [GO:0007399]; neural nucleus development [GO:0048857]; positive regulation of transcription by RNA polymerase II [GO:0045944]; rhombomere 3 development [GO:0021569]; rhombomere 4 development [GO:0021570]	SUBCELLULAR LOCATION: Nucleus.
P14653	reviewed	HXB1_HUMAN	Homeobox protein Hox-B1 (Homeobox protein Hox-2I)	HOXB1 HOX2I	Homo sapiens (Human)	301	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.		anatomical structure formation involved in morphogenesis [GO:0048646]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; facial nerve structural organization [GO:0021612]; facial nucleus development [GO:0021754]; pattern specification process [GO:0007389]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rhombomere 4 development [GO:0021570]; rhombomere 5 development [GO:0021571]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure formation involved in morphogenesis [GO:0048646]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; facial nerve structural organization [GO:0021612]; facial nucleus development [GO:0021754]; pattern specification process [GO:0007389]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rhombomere 4 development [GO:0021570]; rhombomere 5 development [GO:0021571]	SUBCELLULAR LOCATION: Nucleus.
P14672	reviewed	GLUT4_HUMAN	Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)	SLC2A4 GLUT4	Homo sapiens (Human)	509	FUNCTION: Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. {ECO:0000250|UniProtKB:P19357}.	MISCELLANEOUS: Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation. {ECO:0000250|UniProtKB:P14142}.	amylopectin biosynthetic process [GO:0010021]; brown fat cell differentiation [GO:0050873]; carbohydrate metabolic process [GO:0005975]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to osmotic stress [GO:0071470]; cellular response to tumor necrosis factor [GO:0071356]; dehydroascorbic acid transport [GO:0070837]; glucose homeostasis [GO:0042593]; glucose import [GO:0046323]; glucose import in response to insulin stimulus [GO:0044381]; glucose transmembrane transport [GO:1904659]; learning or memory [GO:0007611]; long-term memory [GO:0007616]; positive regulation of brain-derived neurotrophic factor receptor signaling pathway [GO:0031550]; regulation of synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0098694]; response to ethanol [GO:0045471]; short-term memory [GO:0007614]; transport across blood-brain barrier [GO:0150104]; white fat cell proliferation [GO:0070343]	cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; insulin-responsive compartment [GO:0032593]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; T-tubule [GO:0030315]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]; vesicle membrane [GO:0012506]	D-glucose transmembrane transporter activity [GO:0055056]; glucose transmembrane transporter activity [GO:0005355]; glucose uniporter activity [GO:0015304]	cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; insulin-responsive compartment [GO:0032593]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; T-tubule [GO:0030315]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]; vesicle membrane [GO:0012506]; D-glucose transmembrane transporter activity [GO:0055056]; glucose transmembrane transporter activity [GO:0005355]; glucose uniporter activity [GO:0015304]; amylopectin biosynthetic process [GO:0010021]; brown fat cell differentiation [GO:0050873]; carbohydrate metabolic process [GO:0005975]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to osmotic stress [GO:0071470]; cellular response to tumor necrosis factor [GO:0071356]; dehydroascorbic acid transport [GO:0070837]; glucose homeostasis [GO:0042593]; glucose import [GO:0046323]; glucose import in response to insulin stimulus [GO:0044381]; glucose transmembrane transport [GO:1904659]; learning or memory [GO:0007611]; long-term memory [GO:0007616]; positive regulation of brain-derived neurotrophic factor receptor signaling pathway [GO:0031550]; regulation of synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0098694]; response to ethanol [GO:0045471]; short-term memory [GO:0007614]; transport across blood-brain barrier [GO:0150104]; white fat cell proliferation [GO:0070343]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P14142}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P14142}. Endomembrane system {ECO:0000269|PubMed:8300557}; Multi-pass membrane protein {ECO:0000269|PubMed:8300557}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P14142}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:8300557). The dileucine internalization motif is critical for intracellular sequestration (PubMed:8300557). Insulin stimulation induces translocation to the cell membrane (By similarity). {ECO:0000250|UniProtKB:P14142, ECO:0000269|PubMed:8300557}.
P14678	reviewed	RSMB_HUMAN	Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/B') (SmB/B')	SNRPB COD SNRPB1	Homo sapiens (Human)	240	FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (PubMed:12975319). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12975319, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}.	MISCELLANEOUS: Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. B/b' bear Sm epitopes.	7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; protein methylation [GO:0006479]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone pre-mRNA 3'end processing complex [GO:0071204]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683]	histone pre-mRNA DCP binding [GO:0071208]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; U1 snRNP binding [GO:1990446]; U2 snRNP binding [GO:1990447]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone pre-mRNA 3'end processing complex [GO:0071204]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683]; histone pre-mRNA DCP binding [GO:0071208]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; U1 snRNP binding [GO:1990446]; U2 snRNP binding [GO:1990447]; 7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; protein methylation [GO:0006479]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
P14679	reviewed	TYRO_HUMAN	Tyrosinase (EC 1.14.18.1) (LB24-AB) (Monophenol monooxygenase) (SK29-AB) (Tumor rejection antigen AB)	TYR	Homo sapiens (Human)	529	FUNCTION: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed:28661582). {ECO:0000250|UniProtKB:P11344, ECO:0000269|PubMed:28661582}.		cell population proliferation [GO:0008283]; eye pigment biosynthetic process [GO:0006726]; melanin biosynthetic process [GO:0042438]; melanin biosynthetic process from tyrosine [GO:0006583]; pigmentation [GO:0043473]; response to blue light [GO:0009637]; response to cAMP [GO:0051591]; response to UV [GO:0009411]; response to vitamin D [GO:0033280]; thymus development [GO:0048538]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; perinuclear region of cytoplasm [GO:0048471]	copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; tyrosinase activity [GO:0004503]	cytoplasm [GO:0005737]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; perinuclear region of cytoplasm [GO:0048471]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; tyrosinase activity [GO:0004503]; cell population proliferation [GO:0008283]; eye pigment biosynthetic process [GO:0006726]; melanin biosynthetic process [GO:0042438]; melanin biosynthetic process from tyrosine [GO:0006583]; pigmentation [GO:0043473]; response to blue light [GO:0009637]; response to cAMP [GO:0051591]; response to UV [GO:0009411]; response to vitamin D [GO:0033280]; thymus development [GO:0048538]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000250|UniProtKB:P11344}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250|UniProtKB:P11344}.
P14735	reviewed	IDE_HUMAN	Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)	IDE	Homo sapiens (Human)	1019	FUNCTION: Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (PubMed:2293021, PubMed:10684867, PubMed:26968463, PubMed:17051221, PubMed:17613531, PubMed:18986166, PubMed:19321446, PubMed:23922390, PubMed:24847884, PubMed:26394692, PubMed:29596046, PubMed:21098034). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (PubMed:23922390, PubMed:26394692, PubMed:29596046). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity). Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (PubMed:9830016, PubMed:26394692) (Probable). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (PubMed:21098034). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (PubMed:21098034). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I. {ECO:0000250|UniProtKB:Q9JHR7, ECO:0000269|PubMed:10684867, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0000269|PubMed:20364150, ECO:0000269|PubMed:21098034, ECO:0000269|PubMed:2293021, ECO:0000269|PubMed:23922390, ECO:0000269|PubMed:24847884, ECO:0000269|PubMed:26394692, ECO:0000269|PubMed:26968463, ECO:0000269|PubMed:29596046, ECO:0000269|PubMed:9830016, ECO:0000305|PubMed:23922390}.; FUNCTION: (Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV). {ECO:0000269|PubMed:17055432, ECO:0000269|PubMed:17553876}.	MISCELLANEOUS: ATP-binding induces a conformation change. {ECO:0000269|PubMed:17613531}.	amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta metabolic process [GO:0050435]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; bradykinin catabolic process [GO:0010815]; hormone catabolic process [GO:0042447]; insulin catabolic process [GO:1901143]; insulin metabolic process [GO:1901142]; insulin receptor signaling pathway [GO:0008286]; peptide catabolic process [GO:0043171]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of aerobic respiration [GO:1903715]; ubiquitin recycling [GO:0010992]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	ATP binding [GO:0005524]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; metalloendopeptidase activity [GO:0004222]; peptide binding [GO:0042277]; protein homodimerization activity [GO:0042803]; ubiquitin-dependent protein binding [GO:0140036]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; ATP binding [GO:0005524]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; metalloendopeptidase activity [GO:0004222]; peptide binding [GO:0042277]; protein homodimerization activity [GO:0042803]; ubiquitin-dependent protein binding [GO:0140036]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]; amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta metabolic process [GO:0050435]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; bradykinin catabolic process [GO:0010815]; hormone catabolic process [GO:0042447]; insulin catabolic process [GO:1901143]; insulin metabolic process [GO:1901142]; insulin receptor signaling pathway [GO:0008286]; peptide catabolic process [GO:0043171]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of aerobic respiration [GO:1903715]; ubiquitin recycling [GO:0010992]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20364150, ECO:0000269|PubMed:9830016}. Cell membrane {ECO:0000250|UniProtKB:P35559}. Secreted {ECO:0000269|PubMed:9830016}. Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
P14770	reviewed	GPIX_HUMAN	Platelet glycoprotein IX (GP-IX) (GPIX) (Glycoprotein 9) (CD antigen CD42a)	GP9	Homo sapiens (Human)	177	FUNCTION: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.	MISCELLANEOUS: Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.	blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; megakaryocyte development [GO:0035855]; positive regulation of platelet activation [GO:0010572]; release of sequestered calcium ion into cytosol [GO:0051209]	glycoprotein Ib-IX-V complex [GO:1990779]; plasma membrane [GO:0005886]		glycoprotein Ib-IX-V complex [GO:1990779]; plasma membrane [GO:0005886]; blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; megakaryocyte development [GO:0035855]; positive regulation of platelet activation [GO:0010572]; release of sequestered calcium ion into cytosol [GO:0051209]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P14778	reviewed	IL1R1_HUMAN	Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]	IL1R1 IL1R IL1RA IL1RT1	Homo sapiens (Human)	569	FUNCTION: Receptor for IL1A, IL1B and IL1RN (PubMed:2950091). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:10671496, ECO:0000269|PubMed:2950091}.		cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; positive regulation of interleukin-1-mediated signaling pathway [GO:2000661]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of type II interferon production [GO:0032729]; regulation of inflammatory response [GO:0050727]; response to interleukin-1 [GO:0070555]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	interleukin-1 binding [GO:0019966]; interleukin-1 receptor activity [GO:0004908]; interleukin-1, type I, activating receptor activity [GO:0004909]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; platelet-derived growth factor receptor binding [GO:0005161]; protease binding [GO:0002020]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; interleukin-1 binding [GO:0019966]; interleukin-1 receptor activity [GO:0004908]; interleukin-1, type I, activating receptor activity [GO:0004909]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; platelet-derived growth factor receptor binding [GO:0005161]; protease binding [GO:0002020]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; positive regulation of interleukin-1-mediated signaling pathway [GO:2000661]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of type II interferon production [GO:0032729]; regulation of inflammatory response [GO:0050727]; response to interleukin-1 [GO:0070555]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8142597}; Single-pass type I membrane protein {ECO:0000269|PubMed:8142597}. Cell membrane {ECO:0000305|PubMed:8142597}. Secreted {ECO:0000269|PubMed:8142597}.
P14780	reviewed	MMP9_HUMAN	Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]	MMP9 CLG4B	Homo sapiens (Human)	707	FUNCTION: Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed:2551898, PubMed:1480034, PubMed:12879005). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond (PubMed:12879005). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:32883094). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (PubMed:1480034). Degrades fibronectin but not laminin or Pz-peptide. {ECO:0000250|UniProtKB:P41245, ECO:0000269|PubMed:12879005, ECO:0000269|PubMed:1480034, ECO:0000269|PubMed:2551898, ECO:0000269|PubMed:32883094}.	MISCELLANEOUS: In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.	apoptotic process [GO:0006915]; cell migration [GO:0016477]; cellular response to cadmium ion [GO:0071276]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; embryo implantation [GO:0007566]; endodermal cell differentiation [GO:0035987]; ephrin receptor signaling pathway [GO:0048013]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; macrophage differentiation [GO:0030225]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cation channel activity [GO:2001258]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]; negative regulation of epithelial cell differentiation involved in kidney development [GO:2000697]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA binding [GO:0043388]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor binding [GO:1900122]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteolysis [GO:0006508]; regulation of neuroinflammatory response [GO:0150077]; response to amyloid-beta [GO:1904645]; skeletal system development [GO:0001501]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724]	collagen binding [GO:0005518]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724]; collagen binding [GO:0005518]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; cell migration [GO:0016477]; cellular response to cadmium ion [GO:0071276]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; embryo implantation [GO:0007566]; endodermal cell differentiation [GO:0035987]; ephrin receptor signaling pathway [GO:0048013]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; macrophage differentiation [GO:0030225]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cation channel activity [GO:2001258]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]; negative regulation of epithelial cell differentiation involved in kidney development [GO:2000697]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA binding [GO:0043388]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor binding [GO:1900122]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteolysis [GO:0006508]; regulation of neuroinflammatory response [GO:0150077]; response to amyloid-beta [GO:1904645]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:2551898}.
P14784	reviewed	IL2RB_HUMAN	Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)	IL2RB IL15RB	Homo sapiens (Human)	551	FUNCTION: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185). {ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:31040184, ECO:0000269|PubMed:31040185}.		cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; negative regulation of apoptotic process [GO:0043066]; positive regulation of phagocytosis [GO:0050766]; protein-containing complex assembly [GO:0065003]; signal transduction [GO:0007165]	cell surface [GO:0009986]; cytosol [GO:0005829]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; interleukin-2 receptor complex [GO:0005893]; membrane [GO:0016020]; plasma membrane [GO:0005886]	coreceptor activity [GO:0015026]; cytokine receptor activity [GO:0004896]; interleukin-15 receptor activity [GO:0042010]; interleukin-2 binding [GO:0019976]; interleukin-2 receptor activity [GO:0004911]	cell surface [GO:0009986]; cytosol [GO:0005829]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; interleukin-2 receptor complex [GO:0005893]; membrane [GO:0016020]; plasma membrane [GO:0005886]; coreceptor activity [GO:0015026]; cytokine receptor activity [GO:0004896]; interleukin-15 receptor activity [GO:0042010]; interleukin-2 binding [GO:0019976]; interleukin-2 receptor activity [GO:0004911]; cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; negative regulation of apoptotic process [GO:0043066]; positive regulation of phagocytosis [GO:0050766]; protein-containing complex assembly [GO:0065003]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:31040184, ECO:0000269|PubMed:31040185}; Single-pass type I membrane protein {ECO:0000255}.
P14854	reviewed	CX6B1_HUMAN	Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1)	COX6B1 COX6B	Homo sapiens (Human)	86	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:Q01519}.		cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; substantia nigra development [GO:0021762]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]	cytochrome-c oxidase activity [GO:0004129]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]; cytochrome-c oxidase activity [GO:0004129]; cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Peripheral membrane protein {ECO:0000269|PubMed:30030519}; Intermembrane side {ECO:0000269|PubMed:30030519}.
P14859	reviewed	PO2F1_HUMAN	POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1)	POU2F1 OCT1 OTF1	Homo sapiens (Human)	743	FUNCTION: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}.		negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; sequence-specific DNA binding [GO:0043565]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P14866	reviewed	HNRPL_HUMAN	Heterogeneous nuclear ribonucleoprotein L (hnRNP L)	HNRNPL HNRPL P/OKcl.14	Homo sapiens (Human)	589	FUNCTION: Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}.	MISCELLANEOUS: Excess hnRNP L activates NMD of its own mRNA by promoting the inclusion of a 'poison exon' containing a premature stop codon and leading to nonsense-mediated decay. It also cross-regulates inclusion of an analogous 'poison exon' in the hnRNP L-like pre-mRNA (PubMed:19124611). {ECO:0000305|PubMed:19124611}.	mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770]	mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770]; mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:2687284, ECO:0000305|PubMed:26051023, ECO:0000305|PubMed:36537238}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules. {ECO:0000269|PubMed:17289661}.
P14867	reviewed	GBRA1_HUMAN	Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1)	GABRA1	Homo sapiens (Human)	456	FUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). {ECO:0000250|UniProtKB:P62812, ECO:0000250|UniProtKB:P62813, ECO:0000269|PubMed:23909897, ECO:0000269|PubMed:25489750, ECO:0000269|PubMed:29950725}.		chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; dendrite membrane [GO:0032590]; GABA receptor complex [GO:1902710]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; dendrite membrane [GO:0032590]; GABA receptor complex [GO:1902710]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P08219}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:2465923}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P62813}.
P14868	reviewed	SYDC_HUMAN	Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein)	DARS1 DARS PIG40	Homo sapiens (Human)	501	FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000250|UniProtKB:P15178}.		aspartyl-tRNA aminoacylation [GO:0006422]; protein-containing complex assembly [GO:0065003]; translation [GO:0006412]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202]	aminoacylase activity [GO:0004046]; aspartate-tRNA ligase activity [GO:0004815]; ATP binding [GO:0005524]; RNA binding [GO:0003723]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202]; aminoacylase activity [GO:0004046]; aspartate-tRNA ligase activity [GO:0004815]; ATP binding [GO:0005524]; RNA binding [GO:0003723]; aspartyl-tRNA aminoacylation [GO:0006422]; protein-containing complex assembly [GO:0065003]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}.
P14902	reviewed	I23O1_HUMAN	Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)	IDO1 IDO INDO	Homo sapiens (Human)	403	FUNCTION: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). {ECO:0000269|PubMed:14502282, ECO:0000269|PubMed:17671174, ECO:0000303|PubMed:23103127, ECO:0000303|PubMed:25157255, ECO:0000303|PubMed:25691885}.	MISCELLANEOUS: IDO1 is the target for therapy in a range of clinical settings, including cancer, chronic infections, autoimmune and allergic syndromes, and transplantation. {ECO:0000303|PubMed:25970480}.; MISCELLANEOUS: IDO1 and IDO2 are 2 distinct enzymes which catalyze the same reaction. IDO2 affinity for tryptophan is much lower than that of IDO1. 50% of Caucasians harbor polymorphisms which abolish IDO2 enzymatic activity. IDO2 is expressed in human tumors in an inactive form: tryptophan degradation is entirely provided by IDO1 in these cells (PubMed:18418598). IDO2 may play a role as a negative regulator of IDO1 by competing for heme-binding with IDO1 (PubMed:25394548). Low efficiency IDO2 enzymes have been conserved throughout vertebrate evolution, whereas higher efficiency IDO1 enzymes are dispensable in many lower vertebrate lineages (PubMed:25950090). IDO1 may have arisen by gene duplication of a more ancient proto-IDO gene before the divergence of marsupial and eutherian (placental) mammals. {ECO:0000269|PubMed:18418598, ECO:0000269|PubMed:25394548, ECO:0000269|PubMed:25950090}.; MISCELLANEOUS: Elevated IDO1 expression is a hallmark of major viral infections including HIV, HBV, HCV or influenza and also of major bacteria infections, such as Tb, CAP, listeriosis and sepsis. Depletion of tryptophan and production of tryptophan metabolites with bactericidal activity are important as direct anti-pathogen mechanisms. Pathogens are able to highjack the immunosuppressive effects of IDO1 and make use of them to facilitate their own life cycle. {ECO:0000303|PubMed:25157255}.	'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; female pregnancy [GO:0007565]; inflammatory response [GO:0006954]; kynurenic acid biosynthetic process [GO:0034276]; multicellular organismal response to stress [GO:0033555]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of chronic inflammatory response [GO:0002678]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of T cell apoptotic process [GO:0070234]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of type 2 immune response [GO:0002830]; response to lipopolysaccharide [GO:0032496]; swimming behavior [GO:0036269]; T cell proliferation [GO:0042098]; tryptophan catabolic process [GO:0006569]; tryptophan catabolic process to kynurenine [GO:0019441]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; smooth muscle contractile fiber [GO:0030485]; stereocilium bundle [GO:0032421]	electron transfer activity [GO:0009055]; heme binding [GO:0020037]; indoleamine 2,3-dioxygenase activity [GO:0033754]; metal ion binding [GO:0046872]; tryptophan 2,3-dioxygenase activity [GO:0004833]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; smooth muscle contractile fiber [GO:0030485]; stereocilium bundle [GO:0032421]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; indoleamine 2,3-dioxygenase activity [GO:0033754]; metal ion binding [GO:0046872]; tryptophan 2,3-dioxygenase activity [GO:0004833]; 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; female pregnancy [GO:0007565]; inflammatory response [GO:0006954]; kynurenic acid biosynthetic process [GO:0034276]; multicellular organismal response to stress [GO:0033555]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of chronic inflammatory response [GO:0002678]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of T cell apoptotic process [GO:0070234]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of type 2 immune response [GO:0002830]; response to lipopolysaccharide [GO:0032496]; swimming behavior [GO:0036269]; T cell proliferation [GO:0042098]; tryptophan catabolic process [GO:0006569]; tryptophan catabolic process to kynurenine [GO:0019441]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P28776, ECO:0000303|PubMed:25691885}.
P14920	reviewed	OXDA_HUMAN	D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3)	DAO DAMOX	Homo sapiens (Human)	347	FUNCTION: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. {ECO:0000269|PubMed:17303072}.		D-alanine catabolic process [GO:0055130]; D-serine catabolic process [GO:0036088]; D-serine metabolic process [GO:0070178]; dopamine biosynthetic process [GO:0042416]; proline catabolic process [GO:0006562]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	D-amino-acid oxidase activity [GO:0003884]; FAD binding [GO:0071949]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; D-amino-acid oxidase activity [GO:0003884]; FAD binding [GO:0071949]; identical protein binding [GO:0042802]; D-alanine catabolic process [GO:0055130]; D-serine catabolic process [GO:0036088]; D-serine metabolic process [GO:0070178]; dopamine biosynthetic process [GO:0042416]; proline catabolic process [GO:0006562]	SUBCELLULAR LOCATION: Peroxisome.
P14921	reviewed	ETS1_HUMAN	Protein C-ets-1 (p54)	ETS1 EWSR2	Homo sapiens (Human)	441	FUNCTION: Transcription factor (PubMed:10698492, PubMed:11909962). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (PubMed:20378371). May control the differentiation, survival and proliferation of lymphoid cells (PubMed:20378371). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (PubMed:15247905, PubMed:15592518). {ECO:0000269|PubMed:10698492, ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000303|PubMed:20378371}.; FUNCTION: [Isoform Ets-1 p27]: Acts as a dominant-negative for isoform c-ETS-1A. {ECO:0000269|PubMed:19377509}.		cell motility [GO:0048870]; immune response [GO:0006955]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; PML body organization [GO:0030578]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]; response to antibiotic [GO:0046677]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; nuclear receptor coactivator activity [GO:0030374]; nucleic acid binding [GO:0003676]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; nuclear receptor coactivator activity [GO:0030374]; nucleic acid binding [GO:0003676]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; cell motility [GO:0048870]; immune response [GO:0006955]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; PML body organization [GO:0030578]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]; response to antibiotic [GO:0046677]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:19377509}. Cytoplasm {ECO:0000269|PubMed:19377509}. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. {ECO:0000269|PubMed:19377509}.
P14923	reviewed	PLAK_HUMAN	Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)	JUP CTNNG DP3	Homo sapiens (Human)	745	FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}.		bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cellular response to indole-3-methanol [GO:0071681]; desmosome assembly [GO:0002159]; detection of mechanical stimulus [GO:0050982]; endothelial cell-cell adhesion [GO:0071603]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; regulation of cell population proliferation [GO:0042127]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; skin development [GO:0043588]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; gamma-catenin-TCF7L2 complex [GO:0071665]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-DNA complex [GO:0032993]; specific granule lumen [GO:0035580]; Z disc [GO:0030018]; zonula adherens [GO:0005915]	alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; cytoskeletal protein-membrane anchor activity [GO:0106006]; DNA-binding transcription factor binding [GO:0140297]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; structural molecule activity [GO:0005198]; transcription coactivator activity [GO:0003713]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; gamma-catenin-TCF7L2 complex [GO:0071665]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-DNA complex [GO:0032993]; specific granule lumen [GO:0035580]; Z disc [GO:0030018]; zonula adherens [GO:0005915]; alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; cytoskeletal protein-membrane anchor activity [GO:0106006]; DNA-binding transcription factor binding [GO:0140297]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; structural molecule activity [GO:0005198]; transcription coactivator activity [GO:0003713]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cellular response to indole-3-methanol [GO:0071681]; desmosome assembly [GO:0002159]; detection of mechanical stimulus [GO:0050982]; endothelial cell-cell adhesion [GO:0071603]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; regulation of cell population proliferation [GO:0042127]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; skin development [GO:0043588]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:22781308}. Cell junction, desmosome {ECO:0000269|PubMed:22781308}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22781308}. Membrane {ECO:0000269|PubMed:11790773, ECO:0000269|PubMed:22781308}; Peripheral membrane protein {ECO:0000269|PubMed:22781308}. Note=Cytoplasmic in a soluble and membrane-associated form.
P14927	reviewed	QCR7_HUMAN	Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein)	UQCRB UQBP	Homo sapiens (Human)	111	FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000250|UniProtKB:P00128}.		aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]	mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex III [GO:0005750]		mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex III [GO:0005750]; aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00128}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00128}; Matrix side {ECO:0000250|UniProtKB:P00128}.
P15018	reviewed	LIF_HUMAN	Leukemia inhibitory factor (LIF) (Differentiation-stimulating factor) (D factor) (Melanoma-derived LPL inhibitor) (MLPLI) (Emfilermin)	LIF HILDA	Homo sapiens (Human)	202	FUNCTION: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.		blood vessel remodeling [GO:0001974]; cell morphogenesis [GO:0000902]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; immune response [GO:0006955]; leukemia inhibitory factor signaling pathway [GO:0048861]; lung alveolus development [GO:0048286]; lung lobe morphogenesis [GO:0060463]; lung vasculature development [GO:0060426]; macrophage differentiation [GO:0030225]; meiotic nuclear division [GO:0140013]; muscle organ morphogenesis [GO:0048644]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of hormone secretion [GO:0046888]; negative regulation of meiotic nuclear division [GO:0045835]; neuron development [GO:0048666]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via STAT [GO:0097696]; regulation of cell differentiation [GO:0045595]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; response to hypoxia [GO:0001666]; somatic stem cell population maintenance [GO:0035019]; spongiotrophoblast differentiation [GO:0060708]; stem cell differentiation [GO:0048863]; trophoblast giant cell differentiation [GO:0060707]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; leukemia inhibitory factor receptor binding [GO:0005146]; signaling receptor binding [GO:0005102]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; leukemia inhibitory factor receptor binding [GO:0005146]; signaling receptor binding [GO:0005102]; blood vessel remodeling [GO:0001974]; cell morphogenesis [GO:0000902]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; immune response [GO:0006955]; leukemia inhibitory factor signaling pathway [GO:0048861]; lung alveolus development [GO:0048286]; lung lobe morphogenesis [GO:0060463]; lung vasculature development [GO:0060426]; macrophage differentiation [GO:0030225]; meiotic nuclear division [GO:0140013]; muscle organ morphogenesis [GO:0048644]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of hormone secretion [GO:0046888]; negative regulation of meiotic nuclear division [GO:0045835]; neuron development [GO:0048666]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via STAT [GO:0097696]; regulation of cell differentiation [GO:0045595]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; response to hypoxia [GO:0001666]; somatic stem cell population maintenance [GO:0035019]; spongiotrophoblast differentiation [GO:0060708]; stem cell differentiation [GO:0048863]; trophoblast giant cell differentiation [GO:0060707]	SUBCELLULAR LOCATION: Secreted.
P15036	reviewed	ETS2_HUMAN	Protein C-ets-2	ETS2	Homo sapiens (Human)	469	FUNCTION: Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}.		ectodermal cell fate commitment [GO:0001712]; mesoderm development [GO:0007498]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear glucocorticoid receptor binding [GO:0035259]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear glucocorticoid receptor binding [GO:0035259]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; ectodermal cell fate commitment [GO:0001712]; mesoderm development [GO:0007498]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Nucleus.
P15056	reviewed	BRAF_HUMAN	Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)	BRAF BRAF1 RAFB1	Homo sapiens (Human)	766	FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}.		animal organ morphogenesis [GO:0009887]; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; cellular response to calcium ion [GO:0071277]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to xenobiotic stimulus [GO:0071466]; endothelial cell apoptotic process [GO:0072577]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERK1 and ERK2 cascade [GO:0070371]; establishment of protein localization to membrane [GO:0090150]; face development [GO:0060324]; head morphogenesis [GO:0060323]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; positive regulation of axon regeneration [GO:0048680]; positive regulation of axonogenesis [GO:0050772]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein phosphorylation [GO:0006468]; regulation of T cell differentiation [GO:0045580]; response to cAMP [GO:0051591]; response to peptide hormone [GO:0043434]; somatic stem cell population maintenance [GO:0035019]; stress fiber assembly [GO:0043149]; substrate adhesion-dependent cell spreading [GO:0034446]; synaptic vesicle exocytosis [GO:0016079]; T cell differentiation in thymus [GO:0033077]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trehalose metabolism in response to stress [GO:0070413]; visual learning [GO:0008542]	cell body [GO:0044297]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; MAP kinase kinase activity [GO:0004708]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]	cell body [GO:0044297]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; MAP kinase kinase activity [GO:0004708]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; animal organ morphogenesis [GO:0009887]; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; cellular response to calcium ion [GO:0071277]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to xenobiotic stimulus [GO:0071466]; endothelial cell apoptotic process [GO:0072577]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERK1 and ERK2 cascade [GO:0070371]; establishment of protein localization to membrane [GO:0090150]; face development [GO:0060324]; head morphogenesis [GO:0060323]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; positive regulation of axon regeneration [GO:0048680]; positive regulation of axonogenesis [GO:0050772]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein phosphorylation [GO:0006468]; regulation of T cell differentiation [GO:0045580]; response to cAMP [GO:0051591]; response to peptide hormone [GO:0043434]; somatic stem cell population maintenance [GO:0035019]; stress fiber assembly [GO:0043149]; substrate adhesion-dependent cell spreading [GO:0034446]; synaptic vesicle exocytosis [GO:0016079]; T cell differentiation in thymus [GO:0033077]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trehalose metabolism in response to stress [GO:0070413]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19710016}. Cell membrane {ECO:0000269|PubMed:19710016}. Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. {ECO:0000250}.
P15085	reviewed	CBPA1_HUMAN	Carboxypeptidase A1 (EC 3.4.17.1)	CPA1 CPA	Homo sapiens (Human)	419	FUNCTION: Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (PubMed:8806703). Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (By similarity). {ECO:0000250|UniProtKB:P00730, ECO:0000269|PubMed:8806703}.		leukotriene metabolic process [GO:0006691]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to cadmium ion [GO:0046686]	extracellular space [GO:0005615]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	extracellular space [GO:0005615]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; leukotriene metabolic process [GO:0006691]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to cadmium ion [GO:0046686]	SUBCELLULAR LOCATION: Secreted.
P15086	reviewed	CBPB1_HUMAN	Carboxypeptidase B (EC 3.4.17.2) (Pancreas-specific protein) (PASP)	CPB1 CPB PCPB	Homo sapiens (Human)	417			proteolysis [GO:0006508]	cytoplasmic vesicle [GO:0031410]; extracellular space [GO:0005615]	carboxypeptidase activity [GO:0004180]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	cytoplasmic vesicle [GO:0031410]; extracellular space [GO:0005615]; carboxypeptidase activity [GO:0004180]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P00732}. Zymogen granule lumen {ECO:0000250|UniProtKB:P55261}.
P15090	reviewed	FABP4_HUMAN	Fatty acid-binding protein, adipocyte (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)	FABP4	Homo sapiens (Human)	132	FUNCTION: Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. {ECO:0000250|UniProtKB:P04117}.		brown fat cell differentiation [GO:0050873]; cellular response to lithium ion [GO:0071285]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; fatty acid transport [GO:0015908]; long-chain fatty acid transport [GO:0015909]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of inflammatory response [GO:0050729]; response to bacterium [GO:0009617]; white fat cell differentiation [GO:0050872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; nucleus [GO:0005634]	fatty acid binding [GO:0005504]; hormone receptor binding [GO:0051427]; long-chain fatty acid binding [GO:0036041]; long-chain fatty acid transporter activity [GO:0005324]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; fatty acid binding [GO:0005504]; hormone receptor binding [GO:0051427]; long-chain fatty acid binding [GO:0036041]; long-chain fatty acid transporter activity [GO:0005324]; brown fat cell differentiation [GO:0050873]; cellular response to lithium ion [GO:0071285]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; fatty acid transport [GO:0015908]; long-chain fatty acid transport [GO:0015909]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of inflammatory response [GO:0050729]; response to bacterium [GO:0009617]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P04117}. Nucleus {ECO:0000250|UniProtKB:P04117}. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export. {ECO:0000250|UniProtKB:P04117}.
P15104	reviewed	GLNA_HUMAN	Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225)	GLUL GLNS	Homo sapiens (Human)	373	FUNCTION: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351). {ECO:0000250|UniProtKB:P15105, ECO:0000269|PubMed:16267323, ECO:0000269|PubMed:18662667, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:30158707}.		angiogenesis [GO:0001525]; cell population proliferation [GO:0008283]; cellular response to starvation [GO:0009267]; glutamate catabolic process [GO:0006538]; glutamine biosynthetic process [GO:0006542]; protein palmitoylation [GO:0018345]; regulation of endothelial cell migration [GO:0010594]; regulation of protein localization to nucleolus [GO:1904749]; regulation of sprouting angiogenesis [GO:1903670]; response to glucose [GO:0009749]; ribosome biogenesis [GO:0042254]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; glutamine synthetase activity [GO:0004356]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; glutamine synthetase activity [GO:0004356]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; angiogenesis [GO:0001525]; cell population proliferation [GO:0008283]; cellular response to starvation [GO:0009267]; glutamate catabolic process [GO:0006538]; glutamine biosynthetic process [GO:0006542]; protein palmitoylation [GO:0018345]; regulation of endothelial cell migration [GO:0010594]; regulation of protein localization to nucleolus [GO:1904749]; regulation of sprouting angiogenesis [GO:1903670]; response to glucose [GO:0009749]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:30158707}. Microsome {ECO:0000250|UniProtKB:P09606}. Mitochondrion {ECO:0000250|UniProtKB:P09606}. Cell membrane {ECO:0000269|PubMed:30158707}; Lipid-anchor {ECO:0000269|PubMed:30158707}. Note=Mainly localizes in the cytosol, with a fraction associated with the cell membrane. {ECO:0000269|PubMed:30158707}.
P15121	reviewed	ALDR_HUMAN	Aldo-keto reductase family 1 member B1 (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) (EC 1.1.1.21)	AKR1B1 ALDR1 ALR2	Homo sapiens (Human)	316	FUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:17381426, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:1936586, ECO:0000269|PubMed:21329684, ECO:0000269|PubMed:8343525}.		C21-steroid hormone biosynthetic process [GO:0006700]; carbohydrate metabolic process [GO:0005975]; cellular hyperosmotic salinity response [GO:0071475]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; epithelial cell maturation [GO:0002070]; fructose biosynthetic process [GO:0046370]; L-ascorbic acid biosynthetic process [GO:0019853]; metanephric collecting duct development [GO:0072205]; negative regulation of apoptotic process [GO:0043066]; regulation of urine volume [GO:0035809]; renal water homeostasis [GO:0003091]; retinoid metabolic process [GO:0001523]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]	alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; allyl-alcohol dehydrogenase activity [GO:0047655]; electron transfer activity [GO:0009055]; glyceraldehyde oxidoreductase activity [GO:0043795]; glycerol dehydrogenase [NADP+] activity [GO:0047956]; L-glucuronate reductase activity [GO:0047939]; NADP-retinol dehydrogenase activity [GO:0052650]; prostaglandin H2 endoperoxidase reductase activity [GO:0036130]; retinal dehydrogenase activity [GO:0001758]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; allyl-alcohol dehydrogenase activity [GO:0047655]; electron transfer activity [GO:0009055]; glyceraldehyde oxidoreductase activity [GO:0043795]; glycerol dehydrogenase [NADP+] activity [GO:0047956]; L-glucuronate reductase activity [GO:0047939]; NADP-retinol dehydrogenase activity [GO:0052650]; prostaglandin H2 endoperoxidase reductase activity [GO:0036130]; retinal dehydrogenase activity [GO:0001758]; C21-steroid hormone biosynthetic process [GO:0006700]; carbohydrate metabolic process [GO:0005975]; cellular hyperosmotic salinity response [GO:0071475]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; epithelial cell maturation [GO:0002070]; fructose biosynthetic process [GO:0046370]; L-ascorbic acid biosynthetic process [GO:0019853]; metanephric collecting duct development [GO:0072205]; negative regulation of apoptotic process [GO:0043066]; regulation of urine volume [GO:0035809]; renal water homeostasis [GO:0003091]; retinoid metabolic process [GO:0001523]	SUBCELLULAR LOCATION: Cytoplasm.
P15144	reviewed	AMPN_HUMAN	Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13)	ANPEP APN CD13 PEPN	Homo sapiens (Human)	967	FUNCTION: Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity). {ECO:0000250|UniProtKB:P97449, ECO:0000269|PubMed:10605003, ECO:0000269|PubMed:10676659, ECO:0000269|PubMed:11384645, ECO:0000269|PubMed:12473585, ECO:0000269|PubMed:7576235, ECO:0000269|PubMed:8102610, ECO:0000269|PubMed:9056417}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. {ECO:0000269|PubMed:12551991, ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485, ECO:0000269|PubMed:9367365}.; FUNCTION: (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. {ECO:0000269|PubMed:8105105}.	MISCELLANEOUS: Found to serve as a receptor for tumor-homing peptides, more specifically NGR peptides. It could serve thus as a target for delivering drugs into tumors. Concentration in human hepatic bile, varies from 17.3 to 57.6 micrograms/ml. {ECO:0000269|PubMed:10676659}.	angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237]; peptide binding [GO:0042277]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237]; peptide binding [GO:0042277]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2564851, ECO:0000269|PubMed:9056417}; Single-pass type II membrane protein {ECO:0000305|PubMed:1350662}. Note=Also found as a soluble form. {ECO:0000269|PubMed:7902291}.
P15151	reviewed	PVR_HUMAN	Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)	PVR PVS	Homo sapiens (Human)	417	FUNCTION: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. {ECO:0000269|PubMed:15471548, ECO:0000269|PubMed:15607800}.; FUNCTION: (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. {ECO:0000269|PubMed:2538245}.; FUNCTION: (Microbial infection) Acts as a receptor for Pseudorabies virus. {ECO:0000269|PubMed:9616127}.; FUNCTION: (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells. {ECO:0000269|PubMed:15640804}.	MISCELLANEOUS: The V-type domain is necessary and sufficient for virus binding and uptake.	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271]; susceptibility to T cell mediated cytotoxicity [GO:0060370]	adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cell adhesion molecule binding [GO:0050839]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618]	adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271]; susceptibility to T cell mediated cytotoxicity [GO:0060370]	SUBCELLULAR LOCATION: [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Delta]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Beta]: Secreted.; SUBCELLULAR LOCATION: [Isoform Gamma]: Secreted.
P15153	reviewed	RAC2_HUMAN	Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)	RAC2	Homo sapiens (Human)	192	FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. {ECO:0000269|PubMed:1660188, ECO:0000269|PubMed:30723080}.		actin filament organization [GO:0007015]; bone resorption [GO:0045453]; cell projection assembly [GO:0030031]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; lymphocyte aggregation [GO:0071593]; mast cell proliferation [GO:0070662]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of cell migration [GO:0030334]; regulation of cell-substrate adhesion [GO:0010810]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mast cell chemotaxis [GO:0060753]; regulation of mast cell degranulation [GO:0043304]; regulation of neutrophil migration [GO:1902622]; regulation of respiratory burst [GO:0060263]; regulation of T cell proliferation [GO:0042129]; respiratory burst [GO:0045730]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mitochondrial outer membrane [GO:0005741]; NADPH oxidase complex [GO:0043020]; nuclear envelope [GO:0005635]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase regulator activity [GO:0019887]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mitochondrial outer membrane [GO:0005741]; NADPH oxidase complex [GO:0043020]; nuclear envelope [GO:0005635]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase regulator activity [GO:0019887]; actin filament organization [GO:0007015]; bone resorption [GO:0045453]; cell projection assembly [GO:0030031]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; lymphocyte aggregation [GO:0071593]; mast cell proliferation [GO:0070662]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of cell migration [GO:0030334]; regulation of cell-substrate adhesion [GO:0010810]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mast cell chemotaxis [GO:0060753]; regulation of mast cell degranulation [GO:0043304]; regulation of neutrophil migration [GO:1902622]; regulation of respiratory burst [GO:0060263]; regulation of T cell proliferation [GO:0042129]; respiratory burst [GO:0045730]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm. Note=Membrane-associated when activated.
P15169	reviewed	CBPN_HUMAN	Carboxypeptidase N catalytic chain (CPN) (EC 3.4.17.3) (Anaphylatoxin inactivator) (Arginine carboxypeptidase) (Carboxypeptidase N polypeptide 1) (Carboxypeptidase N small subunit) (Kininase-1) (Lysine carboxypeptidase) (Plasma carboxypeptidase B) (Serum carboxypeptidase N) (SCPN)	CPN1 ACBP	Homo sapiens (Human)	458	FUNCTION: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.		bradykinin catabolic process [GO:0010815]; peptide metabolic process [GO:0006518]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; response to glucocorticoid [GO:0051384]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; bradykinin catabolic process [GO:0010815]; peptide metabolic process [GO:0006518]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; response to glucocorticoid [GO:0051384]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P15170	reviewed	ERF3A_HUMAN	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog)	GSPT1 ERF3A	Homo sapiens (Human)	499	FUNCTION: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:2511002, PubMed:15987998, PubMed:19417105, PubMed:27863242). GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242). GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:16777602, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:15987998, ECO:0000269|PubMed:16777602, ECO:0000269|PubMed:19417105, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:2511002, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:30682371}.		G1/S transition of mitotic cell cycle [GO:0000082]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]; regulation of translational termination [GO:0006449]; translation [GO:0006412]; translational termination [GO:0006415]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; translation release factor complex [GO:0018444]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation release factor activity [GO:0003747]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; translation release factor complex [GO:0018444]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation release factor activity [GO:0003747]; G1/S transition of mitotic cell cycle [GO:0000082]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]; regulation of translational termination [GO:0006449]; translation [GO:0006412]; translational termination [GO:0006415]	
P15172	reviewed	MYOD1_HUMAN	Myoblast determination protein 1 (Class C basic helix-loop-helix protein 1) (bHLHc1) (Myogenic factor 3) (Myf-3)	MYOD1 BHLHC1 MYF3 MYOD	Homo sapiens (Human)	320	FUNCTION: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). {ECO:0000250}.		cellular response to estradiol stimulus [GO:0071392]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to oxygen levels [GO:0071453]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; muscle cell fate commitment [GO:0042693]; muscle organ development [GO:0007517]; myoblast fate determination [GO:0007518]; myoblast fusion [GO:0007520]; myotube cell development [GO:0014904]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; negative regulation of myoblast proliferation [GO:2000818]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of skeletal muscle tissue regeneration [GO:0043415]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue development [GO:0007519]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; euchromatin [GO:0000791]; myofibril [GO:0030016]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	bHLH transcription factor binding [GO:0043425]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; euchromatin [GO:0000791]; myofibril [GO:0030016]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; bHLH transcription factor binding [GO:0043425]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; ubiquitin protein ligase binding [GO:0031625]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to oxygen levels [GO:0071453]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; muscle cell fate commitment [GO:0042693]; muscle organ development [GO:0007517]; myoblast fate determination [GO:0007518]; myoblast fusion [GO:0007520]; myotube cell development [GO:0014904]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; negative regulation of myoblast proliferation [GO:2000818]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of skeletal muscle tissue regeneration [GO:0043415]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue development [GO:0007519]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
P15173	reviewed	MYOG_HUMAN	Myogenin (Class C basic helix-loop-helix protein 3) (bHLHc3) (Myogenic factor 4) (Myf-4)	MYOG BHLHC3 MYF4	Homo sapiens (Human)	224	FUNCTION: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity). {ECO:0000250}.		cell cycle [GO:0007049]; cellular response to estradiol stimulus [GO:0071392]; cellular response to growth factor stimulus [GO:0071363]; cellular response to lithium ion [GO:0071285]; cellular response to tumor necrosis factor [GO:0071356]; muscle cell fate commitment [GO:0042693]; negative regulation of cell population proliferation [GO:0008285]; ossification [GO:0001503]; positive regulation of muscle atrophy [GO:0014737]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of myoblast fusion [GO:1901739]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878]; response to muscle activity involved in regulation of muscle adaptation [GO:0014873]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue development [GO:0007519]; striated muscle atrophy [GO:0014891]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]	chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; cell cycle [GO:0007049]; cellular response to estradiol stimulus [GO:0071392]; cellular response to growth factor stimulus [GO:0071363]; cellular response to lithium ion [GO:0071285]; cellular response to tumor necrosis factor [GO:0071356]; muscle cell fate commitment [GO:0042693]; negative regulation of cell population proliferation [GO:0008285]; ossification [GO:0001503]; positive regulation of muscle atrophy [GO:0014737]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of myoblast fusion [GO:1901739]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878]; response to muscle activity involved in regulation of muscle adaptation [GO:0014873]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue development [GO:0007519]; striated muscle atrophy [GO:0014891]	SUBCELLULAR LOCATION: Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos. {ECO:0000250}.
P15248	reviewed	IL9_HUMAN	Interleukin-9 (IL-9) (Cytokine P40) (T-cell growth factor P40)	IL9	Homo sapiens (Human)	144	FUNCTION: Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:29742432). Affects intestinal epithelial permeability and adaptive immunity (PubMed:29742432). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5. {ECO:0000250|UniProtKB:P15247, ECO:0000269|PubMed:29742432}.		B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of interleukin-5 production [GO:0032754]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-9 receptor binding [GO:0005140]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-9 receptor binding [GO:0005140]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of interleukin-5 production [GO:0032754]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	SUBCELLULAR LOCATION: Secreted.
P15259	reviewed	PGAM2_HUMAN	Phosphoglycerate mutase 2 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase) (Phosphoglycerate mutase isozyme M) (PGAM-M)	PGAM2 PGAMM	Homo sapiens (Human)	253	FUNCTION: Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.		canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; Notch signaling pathway [GO:0007219]; response to mercury ion [GO:0046689]; spermatogenesis [GO:0007283]; striated muscle contraction [GO:0006941]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; phosphoglycerate mutase activity [GO:0004619]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; phosphoglycerate mutase activity [GO:0004619]; canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; Notch signaling pathway [GO:0007219]; response to mercury ion [GO:0046689]; spermatogenesis [GO:0007283]; striated muscle contraction [GO:0006941]	
P15260	reviewed	INGR1_HUMAN	Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)	IFNGR1	Homo sapiens (Human)	489	FUNCTION: Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). {ECO:0000250|UniProtKB:P15261, ECO:0000269|PubMed:10986460, ECO:0000269|PubMed:20015550, ECO:0000269|PubMed:28883123, ECO:0000269|PubMed:2971451, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7617032, ECO:0000269|PubMed:7673114}.		astrocyte activation [GO:0048143]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; microglial cell activation [GO:0001774]; negative regulation of amyloid-beta clearance [GO:1900222]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of gene expression [GO:0010628]; positive regulation of tumor necrosis factor production [GO:0032760]; response to virus [GO:0009615]; signal transduction [GO:0007165]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196]	membrane [GO:0016020]; plasma membrane [GO:0005886]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; type II interferon receptor activity [GO:0004906]	membrane [GO:0016020]; plasma membrane [GO:0005886]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; type II interferon receptor activity [GO:0004906]; astrocyte activation [GO:0048143]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; microglial cell activation [GO:0001774]; negative regulation of amyloid-beta clearance [GO:1900222]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of gene expression [GO:0010628]; positive regulation of tumor necrosis factor production [GO:0032760]; response to virus [GO:0009615]; signal transduction [GO:0007165]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10811850, ECO:0000269|PubMed:28883123}; Single-pass type I membrane protein {ECO:0000255}.
P15289	reviewed	ARSA_HUMAN	Arylsulfatase A (ASA) (EC 3.1.6.8) (Cerebroside-sulfatase) [Cleaved into: Arylsulfatase A component B; Arylsulfatase A component C]	ARSA	Homo sapiens (Human)	507	FUNCTION: Hydrolyzes cerebroside sulfate. {ECO:0000269|PubMed:10751093, ECO:0000269|PubMed:24294900}.	MISCELLANEOUS: The metal cofactor was first identified as magnesium ion, based on the structure of the recombinant protein, but when purified from human placenta, the protein contains 1 calcium ion per subunit.	lipid metabolic process [GO:0006629]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; cerebroside-sulfatase activity [GO:0004098]; sulfuric ester hydrolase activity [GO:0008484]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; cerebroside-sulfatase activity [GO:0004098]; sulfuric ester hydrolase activity [GO:0008484]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:9342345}. Lysosome {ECO:0000305|PubMed:2562955}.
P15291	reviewed	B4GT1_HUMAN	Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1]	B4GALT1 GGTB2	Homo sapiens (Human)	398	FUNCTION: [Beta-1,4-galactosyltransferase 1]: The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. {ECO:0000269|PubMed:16157350}.; FUNCTION: [Processed beta-1,4-galactosyltransferase 1]: The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. {ECO:0000269|PubMed:16157350}.		acute inflammatory response [GO:0002526]; angiogenesis involved in wound healing [GO:0060055]; binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; development of secondary sexual characteristics [GO:0045136]; epithelial cell development [GO:0002064]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; galactose metabolic process [GO:0006012]; lactose biosynthetic process [GO:0005989]; lipid metabolic process [GO:0006629]; macrophage migration [GO:1905517]; negative regulation of epithelial cell proliferation [GO:0050680]; oligosaccharide biosynthetic process [GO:0009312]; penetration of zona pellucida [GO:0007341]; positive regulation of apoptotic process [GO:0043065]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; protein N-linked glycosylation [GO:0006487]; regulation of acrosome reaction [GO:0060046]	azurophil granule membrane [GO:0035577]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; desmosome [GO:0030057]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule membrane [GO:0030667]	alpha-tubulin binding [GO:0043014]; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; beta-tubulin binding [GO:0048487]; cytoskeletal protein binding [GO:0008092]; galactosyltransferase activity [GO:0008378]; identical protein binding [GO:0042802]; lactose synthase activity [GO:0004461]; manganese ion binding [GO:0030145]; N-acetyllactosamine synthase activity [GO:0003945]; UDP-galactosyltransferase activity [GO:0035250]	azurophil granule membrane [GO:0035577]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; desmosome [GO:0030057]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule membrane [GO:0030667]; alpha-tubulin binding [GO:0043014]; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; beta-tubulin binding [GO:0048487]; cytoskeletal protein binding [GO:0008092]; galactosyltransferase activity [GO:0008378]; identical protein binding [GO:0042802]; lactose synthase activity [GO:0004461]; manganese ion binding [GO:0030145]; N-acetyllactosamine synthase activity [GO:0003945]; UDP-galactosyltransferase activity [GO:0035250]; acute inflammatory response [GO:0002526]; angiogenesis involved in wound healing [GO:0060055]; binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; development of secondary sexual characteristics [GO:0045136]; epithelial cell development [GO:0002064]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; galactose metabolic process [GO:0006012]; lactose biosynthetic process [GO:0005989]; lipid metabolic process [GO:0006629]; macrophage migration [GO:1905517]; negative regulation of epithelial cell proliferation [GO:0050680]; oligosaccharide biosynthetic process [GO:0009312]; penetration of zona pellucida [GO:0007341]; positive regulation of apoptotic process [GO:0043065]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; protein N-linked glycosylation [GO:0006487]; regulation of acrosome reaction [GO:0060046]	SUBCELLULAR LOCATION: [Isoform Long]: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:1714903, ECO:0000269|PubMed:20378551}; Single-pass type II membrane protein. Cell membrane {ECO:0000269|PubMed:1714903}; Single-pass type II membrane protein. Cell surface {ECO:0000269|PubMed:1714903}. Cell projection, filopodium {ECO:0000250|UniProtKB:P15535}. Note=Found in trans cisternae of Golgi but is mainly localized at the plasma membrane (PubMed:1714903). B4GALT1 cell surface expression is regulated by UBE2Q1 (By similarity). {ECO:0000250|UniProtKB:P15535, ECO:0000269|PubMed:1714903}.; SUBCELLULAR LOCATION: [Isoform Short]: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:1714903}; Single-pass type II membrane protein. Note=Found in trans cisternae of Golgi. {ECO:0000269|PubMed:1714903}.; SUBCELLULAR LOCATION: [Processed beta-1,4-galactosyltransferase 1]: Secreted {ECO:0000303|PubMed:2120039}. Note=Soluble form found in body fluids. {ECO:0000303|PubMed:2120039}.
P15309	reviewed	PPAP_HUMAN	Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5'-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39]	ACP3 ACPP	Homo sapiens (Human)	386	FUNCTION: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins (PubMed:10506173, PubMed:15280042, PubMed:20498373, PubMed:9584846). Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (PubMed:10506173, PubMed:15280042). {ECO:0000269|PubMed:10506173, ECO:0000269|PubMed:15280042, ECO:0000269|PubMed:20498373, ECO:0000269|PubMed:9584846}.; FUNCTION: [Isoform 2]: Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling (PubMed:20498373). In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor (By similarity). {ECO:0000250|UniProtKB:Q8CE08, ECO:0000269|PubMed:20498373}.; FUNCTION: [PAPf39]: (Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection (PubMed:18083097, PubMed:19451623, PubMed:19897482). SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea (PubMed:19451623). Target cell attachment and enhancement of HIV infection is inhibited by surfen (PubMed:19897482). Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection (PubMed:19403677). {ECO:0000269|PubMed:18083097, ECO:0000269|PubMed:19403677, ECO:0000269|PubMed:19451623, ECO:0000269|PubMed:19897482}.	MISCELLANEOUS: Has been used as a diagnostic tool for staging metastatic prostatic cancer.	adenosine metabolic process [GO:0046085]; dephosphorylation [GO:0016311]; lipid metabolic process [GO:0006629]; lysosome organization [GO:0007040]; nucleotide metabolic process [GO:0009117]; positive regulation of adenosine receptor signaling pathway [GO:0060168]; purine nucleobase metabolic process [GO:0006144]; regulation of sensory perception of pain [GO:0051930]; thiamine metabolic process [GO:0006772]	apical part of cell [GO:0045177]; azurophil granule membrane [GO:0035577]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi cisterna [GO:0031985]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]	5'-nucleotidase activity [GO:0008253]; acid phosphatase activity [GO:0003993]; choline binding [GO:0033265]; identical protein binding [GO:0042802]; lysophosphatidic acid phosphatase activity [GO:0052642]; molecular adaptor activity [GO:0060090]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity [GO:0004725]; thiamine phosphate phosphatase activity [GO:0042131]; XMP 5'-nucleosidase activity [GO:0106411]	apical part of cell [GO:0045177]; azurophil granule membrane [GO:0035577]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi cisterna [GO:0031985]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; 5'-nucleotidase activity [GO:0008253]; acid phosphatase activity [GO:0003993]; choline binding [GO:0033265]; identical protein binding [GO:0042802]; lysophosphatidic acid phosphatase activity [GO:0052642]; molecular adaptor activity [GO:0060090]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity [GO:0004725]; thiamine phosphate phosphatase activity [GO:0042131]; XMP 5'-nucleosidase activity [GO:0106411]; adenosine metabolic process [GO:0046085]; dephosphorylation [GO:0016311]; lipid metabolic process [GO:0006629]; lysosome organization [GO:0007040]; nucleotide metabolic process [GO:0009117]; positive regulation of adenosine receptor signaling pathway [GO:0060168]; purine nucleobase metabolic process [GO:0006144]; regulation of sensory perception of pain [GO:0051930]; thiamine metabolic process [GO:0006772]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000305|PubMed:17638863}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:17638863, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:20498373}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17638863, ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:20498373}. Cytoplasm, cytosol {ECO:0000269|PubMed:20498373}. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (PubMed:17897319). {ECO:0000269|PubMed:17638863, ECO:0000269|PubMed:17897319}.
P15311	reviewed	EZRI_HUMAN	Ezrin (Cytovillin) (Villin-2) (p81)	EZR VIL2	Homo sapiens (Human)	586	FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.		actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; astral microtubule organization [GO:0030953]; cellular response to cAMP [GO:0071320]; cortical microtubule organization [GO:0043622]; establishment of centrosome localization [GO:0051660]; establishment of endothelial barrier [GO:0061028]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; filopodium assembly [GO:0046847]; intestinal D-glucose absorption [GO:0001951]; leukocyte cell-cell adhesion [GO:0007159]; membrane to membrane docking [GO:0022614]; microvillus assembly [GO:0030033]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of gene expression [GO:0010628]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to plasma membrane [GO:1903078]; postsynaptic actin cytoskeleton organization [GO:0098974]; protein kinase A signaling [GO:0010737]; protein localization to cell cortex [GO:0072697]; protein localization to plasma membrane [GO:0072659]; protein-containing complex localization [GO:0031503]; receptor internalization [GO:0031623]; regulation of cell shape [GO:0008360]; regulation of microvillus length [GO:0032532]; regulation of organelle assembly [GO:1902115]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; terminal web assembly [GO:1902896]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cell periphery [GO:0071944]; cell projection [GO:0042995]; ciliary basal body [GO:0036064]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; uropod [GO:0001931]; vesicle [GO:0031982]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein kinase A binding [GO:0051018]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cell periphery [GO:0071944]; cell projection [GO:0042995]; ciliary basal body [GO:0036064]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; uropod [GO:0001931]; vesicle [GO:0031982]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein kinase A binding [GO:0051018]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548]; actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; astral microtubule organization [GO:0030953]; cellular response to cAMP [GO:0071320]; cortical microtubule organization [GO:0043622]; establishment of centrosome localization [GO:0051660]; establishment of endothelial barrier [GO:0061028]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; filopodium assembly [GO:0046847]; intestinal D-glucose absorption [GO:0001951]; leukocyte cell-cell adhesion [GO:0007159]; membrane to membrane docking [GO:0022614]; microvillus assembly [GO:0030033]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of gene expression [GO:0010628]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to plasma membrane [GO:1903078]; postsynaptic actin cytoskeleton organization [GO:0098974]; protein kinase A signaling [GO:0010737]; protein localization to cell cortex [GO:0072697]; protein localization to plasma membrane [GO:0072659]; protein-containing complex localization [GO:0031503]; receptor internalization [GO:0031623]; regulation of cell shape [GO:0008360]; regulation of microvillus length [GO:0032532]; regulation of organelle assembly [GO:1902115]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; terminal web assembly [GO:1902896]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection {ECO:0000269|PubMed:18046454}. Cell projection, microvillus membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18046454}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18046454}. Cell projection, microvillus {ECO:0000250|UniProtKB:P26040}. Note=Localization to the apical membrane of parietal cells depends on the interaction with PALS1. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). {ECO:0000250|UniProtKB:P31977}.
P15313	reviewed	VATB1_HUMAN	V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1)	ATP6V1B1 ATP6B1 VATB VPP3	Homo sapiens (Human)	513	FUNCTION: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:16769747). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). Essential for the proper assembly and activity of V-ATPase (PubMed:16769747). In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification (PubMed:16769747). Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium (By similarity). {ECO:0000250|UniProtKB:Q91YH6, ECO:0000269|PubMed:16769747, ECO:0000303|PubMed:32001091}.		adult behavior [GO:0030534]; ATP metabolic process [GO:0046034]; calcium ion homeostasis [GO:0055074]; chloride ion homeostasis [GO:0055064]; inner ear morphogenesis [GO:0042472]; olfactory behavior [GO:0042048]; ossification [GO:0001503]; pH reduction [GO:0045851]; potassium ion homeostasis [GO:0055075]; prostaglandin metabolic process [GO:0006693]; proton transmembrane transport [GO:1902600]; regulation of gene expression [GO:0010468]; regulation of macroautophagy [GO:0016241]; regulation of pH [GO:0006885]; renal sodium excretion [GO:0035812]; renal sodium ion transport [GO:0003096]; renal tubular secretion [GO:0097254]; renal water homeostasis [GO:0003091]; sensory perception of sound [GO:0007605]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; lateral plasma membrane [GO:0016328]; microvillus [GO:0005902]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	ATP binding [GO:0005524]; protein-containing complex binding [GO:0044877]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; lateral plasma membrane [GO:0016328]; microvillus [GO:0005902]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]; ATP binding [GO:0005524]; protein-containing complex binding [GO:0044877]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; adult behavior [GO:0030534]; ATP metabolic process [GO:0046034]; calcium ion homeostasis [GO:0055074]; chloride ion homeostasis [GO:0055064]; inner ear morphogenesis [GO:0042472]; olfactory behavior [GO:0042048]; ossification [GO:0001503]; pH reduction [GO:0045851]; potassium ion homeostasis [GO:0055075]; prostaglandin metabolic process [GO:0006693]; proton transmembrane transport [GO:1902600]; regulation of gene expression [GO:0010468]; regulation of macroautophagy [GO:0016241]; regulation of pH [GO:0006885]; renal sodium excretion [GO:0035812]; renal sodium ion transport [GO:0003096]; renal tubular secretion [GO:0097254]; renal water homeostasis [GO:0003091]; sensory perception of sound [GO:0007605]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:16769747, ECO:0000269|PubMed:29993276}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q91YH6}.
P15328	reviewed	FOLR1_HUMAN	Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18)	FOLR1 FOLR	Homo sapiens (Human)	257	FUNCTION: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728, PubMed:19074442). Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728). Required for normal embryonic development and normal cell proliferation (By similarity). {ECO:0000250|UniProtKB:P35846, ECO:0000269|PubMed:19074442, ECO:0000269|PubMed:23851396, ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}.		anterior neural tube closure [GO:0061713]; axon regeneration [GO:0031103]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell adhesion [GO:0007155]; cellular response to folic acid [GO:0071231]; folic acid metabolic process [GO:0046655]; folic acid transport [GO:0015884]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; heart looping [GO:0001947]; neural crest cell migration involved in heart formation [GO:0003147]; pharyngeal arch artery morphogenesis [GO:0061626]; receptor-mediated endocytosis [GO:0006898]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; sperm-egg recognition [GO:0035036]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]	folic acid binding [GO:0005542]; folic acid receptor activity [GO:0061714]; signaling receptor activity [GO:0038023]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; folic acid binding [GO:0005542]; folic acid receptor activity [GO:0061714]; signaling receptor activity [GO:0038023]; anterior neural tube closure [GO:0061713]; axon regeneration [GO:0031103]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell adhesion [GO:0007155]; cellular response to folic acid [GO:0071231]; folic acid metabolic process [GO:0046655]; folic acid transport [GO:0015884]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; heart looping [GO:0001947]; neural crest cell migration involved in heart formation [GO:0003147]; pharyngeal arch artery morphogenesis [GO:0061626]; receptor-mediated endocytosis [GO:0006898]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; sperm-egg recognition [GO:0035036]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Apical cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Basolateral cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Secreted {ECO:0000305|PubMed:3476960}. Cytoplasmic vesicle {ECO:0000269|PubMed:8567728}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:8567728}. Endosome {ECO:0000269|PubMed:8567728}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. {ECO:0000269|PubMed:8567728}.
P15336	reviewed	ATF2_HUMAN	Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)	ATF2 CREB2 CREBP1	Homo sapiens (Human)	505	FUNCTION: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}.		abducens nucleus development [GO:0021742]; adipose tissue development [GO:0060612]; apoptotic process involved in development [GO:1902742]; BMP signaling pathway [GO:0030509]; brainstem development [GO:0003360]; cellular lipid metabolic process [GO:0044255]; cellular response to anisomycin [GO:0072740]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; cellular response to virus [GO:0098586]; detection of cell density [GO:0060245]; DNA damage response [GO:0006974]; facial nucleus development [GO:0021754]; growth plate cartilage chondrocyte differentiation [GO:0003418]; growth plate cartilage chondrocyte proliferation [GO:0003419]; hematopoietic progenitor cell differentiation [GO:0002244]; hepatocyte apoptotic process [GO:0097284]; hypoglossal nucleus development [GO:0021743]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; JNK cascade [GO:0007254]; liver development [GO:0001889]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; motor neuron apoptotic process [GO:0097049]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurofilament cytoskeleton organization [GO:0060052]; NK T cell differentiation [GO:0001865]; outflow tract morphogenesis [GO:0003151]; p38MAPK cascade [GO:0038066]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle myoblast proliferation [GO:0110024]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of transforming growth factor beta2 production [GO:0032915]; protein import into nucleus [GO:0006606]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to organic cyclic compound [GO:0014070]; response to osmotic stress [GO:0006970]; transcription initiation-coupled chromatin remodeling [GO:0045815]; vacuole organization [GO:0007033]; white fat cell differentiation [GO:0050872]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; H4 histone acetyltransferase complex [GO:1902562]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; site of double-strand break [GO:0035861]	cAMP response element binding [GO:0035497]; cAMP response element binding protein binding [GO:0008140]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone acetyltransferase activity [GO:0004402]; histone H2B acetyltransferase activity [GO:0044013]; histone H4 acetyltransferase activity [GO:0010485]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; H4 histone acetyltransferase complex [GO:1902562]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; site of double-strand break [GO:0035861]; cAMP response element binding [GO:0035497]; cAMP response element binding protein binding [GO:0008140]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone acetyltransferase activity [GO:0004402]; histone H2B acetyltransferase activity [GO:0044013]; histone H4 acetyltransferase activity [GO:0010485]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; abducens nucleus development [GO:0021742]; adipose tissue development [GO:0060612]; apoptotic process involved in development [GO:1902742]; BMP signaling pathway [GO:0030509]; brainstem development [GO:0003360]; cellular lipid metabolic process [GO:0044255]; cellular response to anisomycin [GO:0072740]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; cellular response to virus [GO:0098586]; detection of cell density [GO:0060245]; DNA damage response [GO:0006974]; facial nucleus development [GO:0021754]; growth plate cartilage chondrocyte differentiation [GO:0003418]; growth plate cartilage chondrocyte proliferation [GO:0003419]; hematopoietic progenitor cell differentiation [GO:0002244]; hepatocyte apoptotic process [GO:0097284]; hypoglossal nucleus development [GO:0021743]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; JNK cascade [GO:0007254]; liver development [GO:0001889]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; motor neuron apoptotic process [GO:0097049]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurofilament cytoskeleton organization [GO:0060052]; NK T cell differentiation [GO:0001865]; outflow tract morphogenesis [GO:0003151]; p38MAPK cascade [GO:0038066]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle myoblast proliferation [GO:0110024]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of transforming growth factor beta2 production [GO:0032915]; protein import into nucleus [GO:0006606]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to organic cyclic compound [GO:0014070]; response to osmotic stress [GO:0006970]; transcription initiation-coupled chromatin remodeling [GO:0045815]; vacuole organization [GO:0007033]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Mitochondrion outer membrane. Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).
P15374	reviewed	UCHL3_HUMAN	Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3)	UCHL3	Homo sapiens (Human)	230	FUNCTION: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0000269|PubMed:9790970}.	MISCELLANEOUS: Identified as a tumor-specific antigen in colon cancer.	post-translational protein modification [GO:0043687]; protein catabolic process [GO:0030163]; protein deubiquitination [GO:0016579]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	cysteine-type deubiquitinase activity [GO:0004843]; deNEDDylase activity [GO:0019784]; peptidase activity [GO:0008233]; ubiquitin binding [GO:0043130]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; cysteine-type deubiquitinase activity [GO:0004843]; deNEDDylase activity [GO:0019784]; peptidase activity [GO:0008233]; ubiquitin binding [GO:0043130]; post-translational protein modification [GO:0043687]; protein catabolic process [GO:0030163]; protein deubiquitination [GO:0016579]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm.
P15382	reviewed	KCNE1_HUMAN	Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel)	KCNE1	Homo sapiens (Human)	129	FUNCTION: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). {ECO:0000269|PubMed:19219384}.		cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to acidic pH [GO:0071468]; cellular response to cAMP [GO:0071320]; cellular response to light stimulus [GO:0071482]; epithelial cell maturation [GO:0002070]; male gonad development [GO:0008584]; membrane repolarization [GO:0086009]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; negative regulation of protein targeting to membrane [GO:0090315]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; regulation of delayed rectifier potassium channel activity [GO:1902259]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; secretory granule organization [GO:0033363]; sensory perception of sound [GO:0007605]; ventricular cardiac muscle cell action potential [GO:0086005]; vestibular nucleus development [GO:0021750]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; lysosome [GO:0005764]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; Z disc [GO:0030018]	delayed rectifier potassium channel activity [GO:0005251]; potassium channel regulator activity [GO:0015459]; protein-containing complex binding [GO:0044877]; telethonin binding [GO:0031433]; transmembrane transporter binding [GO:0044325]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; lysosome [GO:0005764]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; Z disc [GO:0030018]; delayed rectifier potassium channel activity [GO:0005251]; potassium channel regulator activity [GO:0015459]; protein-containing complex binding [GO:0044877]; telethonin binding [GO:0031433]; transmembrane transporter binding [GO:0044325]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to acidic pH [GO:0071468]; cellular response to cAMP [GO:0071320]; cellular response to light stimulus [GO:0071482]; epithelial cell maturation [GO:0002070]; male gonad development [GO:0008584]; membrane repolarization [GO:0086009]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; negative regulation of protein targeting to membrane [GO:0090315]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; regulation of delayed rectifier potassium channel activity [GO:1902259]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; secretory granule organization [GO:0033363]; sensory perception of sound [GO:0007605]; ventricular cardiac muscle cell action potential [GO:0086005]; vestibular nucleus development [GO:0021750]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19219384}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:P15383}. Membrane raft {ECO:0000269|PubMed:20533308}. Note=Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KCNQ1 (PubMed:20533308). {ECO:0000250|UniProtKB:P15383, ECO:0000269|PubMed:20533308}.
P15391	reviewed	CD19_HUMAN	B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)	CD19	Homo sapiens (Human)	556	FUNCTION: Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:9382888, PubMed:9317126, PubMed:12387743, PubMed:16672701). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:2463100, PubMed:1373518). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:9317126, PubMed:12387743, PubMed:16672701). {ECO:0000250|UniProtKB:P25918, ECO:0000269|PubMed:12387743, ECO:0000269|PubMed:1373518, ECO:0000269|PubMed:16672701, ECO:0000269|PubMed:2463100, ECO:0000269|PubMed:9317126, ECO:0000269|PubMed:9382888}.		antigen receptor-mediated signaling pathway [GO:0050851]; B cell proliferation involved in immune response [GO:0002322]; B cell receptor signaling pathway [GO:0050853]; B-1 B cell differentiation [GO:0001923]; immunoglobulin mediated immune response [GO:0016064]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of B cell activation [GO:0050864]; regulation of B cell receptor signaling pathway [GO:0050855]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]		external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell proliferation involved in immune response [GO:0002322]; B cell receptor signaling pathway [GO:0050853]; B-1 B cell differentiation [GO:0001923]; immunoglobulin mediated immune response [GO:0016064]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of B cell activation [GO:0050864]; regulation of B cell receptor signaling pathway [GO:0050855]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1373518, ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:16672701, ECO:0000269|PubMed:1702139, ECO:0000269|PubMed:2463100, ECO:0000269|PubMed:9317126, ECO:0000269|PubMed:9382888}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000250|UniProtKB:P25918}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25918}.
P15407	reviewed	FOSL1_HUMAN	Fos-related antigen 1 (FRA-1)	FOSL1 FRA1	Homo sapiens (Human)	271			cellular defense response [GO:0006968]; cellular response to extracellular stimulus [GO:0031668]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; female pregnancy [GO:0007565]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; integrated stress response signaling [GO:0140467]; learning [GO:0007612]; negative regulation of cell population proliferation [GO:0008285]; placenta blood vessel development [GO:0060674]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of miRNA transcription [GO:1902895]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to corticosterone [GO:0051412]; response to gravity [GO:0009629]; response to hydrogen peroxide [GO:0042542]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to virus [GO:0009615]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; toll-like receptor signaling pathway [GO:0002224]; vitellogenesis [GO:0007296]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynaptic membrane [GO:0042734]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynaptic membrane [GO:0042734]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular defense response [GO:0006968]; cellular response to extracellular stimulus [GO:0031668]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; female pregnancy [GO:0007565]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; integrated stress response signaling [GO:0140467]; learning [GO:0007612]; negative regulation of cell population proliferation [GO:0008285]; placenta blood vessel development [GO:0060674]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of miRNA transcription [GO:1902895]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to corticosterone [GO:0051412]; response to gravity [GO:0009629]; response to hydrogen peroxide [GO:0042542]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to virus [GO:0009615]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; toll-like receptor signaling pathway [GO:0002224]; vitellogenesis [GO:0007296]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P51145}.
P15408	reviewed	FOSL2_HUMAN	Fos-related antigen 2 (FRA-2)	FOSL2 FRA2	Homo sapiens (Human)	326	FUNCTION: Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}.		alveolar secondary septum development [GO:0061144]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; bone mineralization [GO:0030282]; cell death [GO:0008219]; cell morphogenesis [GO:0000902]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; collagen biosynthetic process [GO:0032964]; fat cell apoptotic process [GO:1904606]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; growth plate cartilage development [GO:0003417]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; insulin metabolic process [GO:1901142]; keratinocyte development [GO:0003334]; lung connective tissue development [GO:0060427]; macrophage differentiation [GO:0030225]; mucus secretion [GO:0070254]; multicellular organism growth [GO:0035264]; myofibroblast differentiation [GO:0036446]; neutrophil differentiation [GO:0030223]; NK T cell differentiation [GO:0001865]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of multicellular organism growth [GO:0040014]; regulation of myofibroblast differentiation [GO:1904760]; regulation of transcription by RNA polymerase II [GO:0006357]; response to bleomycin [GO:1904975]; response to glucocorticoid [GO:0051384]; response to Gram-positive bacterium [GO:0140459]; response to hypoxia [GO:0001666]; response to interleukin-13 [GO:0035962]; response to interleukin-7 [GO:0098760]; response to leukemia inhibitory factor [GO:1990823]; response to lipopolysaccharide [GO:0032496]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; T cell receptor signaling pathway [GO:0050852]; tissue remodeling [GO:0048771]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; alveolar secondary septum development [GO:0061144]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; bone mineralization [GO:0030282]; cell death [GO:0008219]; cell morphogenesis [GO:0000902]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; collagen biosynthetic process [GO:0032964]; fat cell apoptotic process [GO:1904606]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; growth plate cartilage development [GO:0003417]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; insulin metabolic process [GO:1901142]; keratinocyte development [GO:0003334]; lung connective tissue development [GO:0060427]; macrophage differentiation [GO:0030225]; mucus secretion [GO:0070254]; multicellular organism growth [GO:0035264]; myofibroblast differentiation [GO:0036446]; neutrophil differentiation [GO:0030223]; NK T cell differentiation [GO:0001865]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of multicellular organism growth [GO:0040014]; regulation of myofibroblast differentiation [GO:1904760]; regulation of transcription by RNA polymerase II [GO:0006357]; response to bleomycin [GO:1904975]; response to glucocorticoid [GO:0051384]; response to Gram-positive bacterium [GO:0140459]; response to hypoxia [GO:0001666]; response to interleukin-13 [GO:0035962]; response to interleukin-7 [GO:0098760]; response to leukemia inhibitory factor [GO:1990823]; response to lipopolysaccharide [GO:0032496]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; T cell receptor signaling pathway [GO:0050852]; tissue remodeling [GO:0048771]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P51145}.
P15428	reviewed	PGDH_HUMAN	15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Eicosanoid/docosanoid dehydrogenase [NAD(+)]) (EC 1.1.1.-, EC 1.1.1.232) (Prostaglandin dehydrogenase 1) (Short chain dehydrogenase/reductase family 36C member 1)	HPGD PGDH1 SDR36C1	Homo sapiens (Human)	266	FUNCTION: Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (PubMed:8086429, PubMed:10837478, PubMed:16828555, PubMed:16757471, PubMed:21916491, PubMed:25586183). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression (PubMed:25586183, PubMed:15574495). Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (PubMed:16757471, PubMed:22844113). {ECO:0000269|PubMed:10837478, ECO:0000269|PubMed:15574495, ECO:0000269|PubMed:16757471, ECO:0000269|PubMed:16828555, ECO:0000269|PubMed:21916491, ECO:0000269|PubMed:22844113, ECO:0000269|PubMed:25586183, ECO:0000269|PubMed:8086429}.		ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; kidney development [GO:0001822]; lipoxygenase pathway [GO:0019372]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; positive regulation of apoptotic process [GO:0043065]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostaglandin metabolic process [GO:0006693]; regulation of prostaglandin catabolic process [GO:1905828]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; thrombin-activated receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	15-hydroxyprostaglandin dehydrogenase (NAD+) activity [GO:0016404]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E receptor activity [GO:0004957]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity [GO:0016404]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E receptor activity [GO:0004957]; ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; kidney development [GO:0001822]; lipoxygenase pathway [GO:0019372]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; positive regulation of apoptotic process [GO:0043065]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostaglandin metabolic process [GO:0006693]; regulation of prostaglandin catabolic process [GO:1905828]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; thrombin-activated receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm.
P15498	reviewed	VAV_HUMAN	Proto-oncogene vav	VAV1 VAV	Homo sapiens (Human)	845	FUNCTION: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.	MISCELLANEOUS: 'Vav' stands for the sixth letter of the Hebrew alphabet.	cell migration [GO:0016477]; cellular response to xenobiotic stimulus [GO:0071466]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; reactive oxygen species metabolic process [GO:0072593]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; T cell costimulation [GO:0031295]; T cell differentiation [GO:0030217]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphorylation-dependent protein binding [GO:0140031]; phosphotyrosine residue binding [GO:0001784]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphorylation-dependent protein binding [GO:0140031]; phosphotyrosine residue binding [GO:0001784]; cell migration [GO:0016477]; cellular response to xenobiotic stimulus [GO:0071466]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; reactive oxygen species metabolic process [GO:0072593]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; T cell costimulation [GO:0031295]; T cell differentiation [GO:0030217]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	
P15502	reviewed	ELN_HUMAN	Elastin (Tropoelastin)	ELN	Homo sapiens (Human)	786	FUNCTION: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). {ECO:0000250|UniProtKB:P54320}.		animal organ morphogenesis [GO:0009887]; aortic valve morphogenesis [GO:0003180]; blood circulation [GO:0008015]; extracellular matrix assembly [GO:0085029]; outflow tract morphogenesis [GO:0003151]; regulation of actin filament polymerization [GO:0030833]; regulation of smooth muscle cell proliferation [GO:0048660]; respiratory gaseous exchange by respiratory system [GO:0007585]; skeletal muscle tissue development [GO:0007519]; stress fiber assembly [GO:0043149]	collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	extracellular matrix binding [GO:0050840]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]	collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular matrix binding [GO:0050840]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; animal organ morphogenesis [GO:0009887]; aortic valve morphogenesis [GO:0003180]; blood circulation [GO:0008015]; extracellular matrix assembly [GO:0085029]; outflow tract morphogenesis [GO:0003151]; regulation of actin filament polymerization [GO:0030833]; regulation of smooth muscle cell proliferation [GO:0048660]; respiratory gaseous exchange by respiratory system [GO:0007585]; skeletal muscle tissue development [GO:0007519]; stress fiber assembly [GO:0043149]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17035250}. Note=Extracellular matrix of elastic fibers. {ECO:0000269|PubMed:17035250}.
P15509	reviewed	CSF2R_HUMAN	Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (GM-CSF-R-alpha) (GMCSFR-alpha) (GMR-alpha) (CDw116) (CD antigen CD116)	CSF2RA CSF2R CSF2RY	Homo sapiens (Human)	400	FUNCTION: Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.	cytokine-mediated signaling pathway [GO:0019221]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; positive regulation of leukocyte proliferation [GO:0070665]; receptor signaling pathway via JAK-STAT [GO:0007259]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; signaling receptor activity [GO:0038023]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; signaling receptor activity [GO:0038023]; cytokine-mediated signaling pathway [GO:0019221]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; positive regulation of leukocyte proliferation [GO:0070665]; receptor signaling pathway via JAK-STAT [GO:0007259]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted {ECO:0000305}.
P15514	reviewed	AREG_HUMAN	Amphiregulin (AR) (Colorectum cell-derived growth factor) (CRDGF)	AREG AREGB SDGF	Homo sapiens (Human)	252	FUNCTION: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.	MISCELLANEOUS: AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.	cell-cell signaling [GO:0007267]; dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis [GO:0060598]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; ERBB2-EGFR signaling pathway [GO:0038134]; G protein-coupled receptor signaling pathway [GO:0007186]; glial cell proliferation [GO:0014009]; mammary gland alveolus development [GO:0060749]; mammary gland branching involved in thelarche [GO:0060744]; negative regulation of osteoblast differentiation [GO:0045668]; neuron projection development [GO:0031175]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; response to cAMP [GO:0051591]; response to estradiol [GO:0032355]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to peptide hormone [GO:0043434]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]	cytokine activity [GO:0005125]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; cytokine activity [GO:0005125]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; cell-cell signaling [GO:0007267]; dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis [GO:0060598]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; ERBB2-EGFR signaling pathway [GO:0038134]; G protein-coupled receptor signaling pathway [GO:0007186]; glial cell proliferation [GO:0014009]; mammary gland alveolus development [GO:0060749]; mammary gland branching involved in thelarche [GO:0060744]; negative regulation of osteoblast differentiation [GO:0045668]; neuron projection development [GO:0031175]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; response to cAMP [GO:0051591]; response to estradiol [GO:0032355]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to peptide hormone [GO:0043434]	SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.
P15515	reviewed	HIS1_HUMAN	Histatin-1 (Histidine-rich protein 1) (Post-PB protein) (PPB) [Cleaved into: His1-(31-57)-peptide (His1 31/57) (His1-(12-38)-peptide) (His1 12/38) (Histatin-2)]	HTN1 HIS1	Homo sapiens (Human)	57	FUNCTION: Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.	MISCELLANEOUS: The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions within the precursor, and not in the mature protein, as has formerly been proposed. {ECO:0000305|PubMed:20973643}.	biomineral tissue development [GO:0031214]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; killing of cells of another organism [GO:0031640]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; biomineral tissue development [GO:0031214]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; killing of cells of another organism [GO:0031640]	SUBCELLULAR LOCATION: Secreted.
P15516	reviewed	HIS3_HUMAN	Histatin-3 (Basic histidine-rich protein) (Hst) (Histidine-rich protein 3) (PB) [Cleaved into: Histatin-3; His3-(20-44)-peptide (His3 20/44) (His3-(1-25)-peptide) (His3 1/25) (Histatin-3 1/25) (Histatin-6); His3-(20-43)-peptide (His3 20/43) (His3-(1-24)-peptide) (His3 1/24) (Histatin-3 1/24) (Histatin-5); His3-(20-32)-peptide (His3 20/32) (His3-(1-13)-peptide) (His3 1/13) (Histatin-3 1/13); His3-(20-31)-peptide (His3 20/31) (His3-(1-12)-peptide) (His3 1/12) (Histatin-3 1/12); His3-(20-30)-peptide (His3 20/30) (His3-(1-11)-peptide) (His3 1/11) (Histatin-3 1/11); His3-(24-32)-peptide (His3 24/32) (His3-(5-13)-peptide) (His3 5/13) (Histatin-3 5/13); His3-(24-31)-peptide (His3 24/31) (His3-(5-12)-peptide) (His3 5/12) (Histatin-11) (Histatin-3 5/12); His3-(24-30)-peptide (His3 24/30) (His3-(5-11)-peptide) (His3 5/11) (Histatin-12) (Histatin-3 5/11); His3-(25-32)-peptide (His3 25/32) (His3-(6-13)-peptide) (His3 6/13) (Histatin-3 6/13); His3-(25-30)-peptide (His3 25/30) (His3-(6-11)-peptide) (His3 6/11) (Histatin-3 6/11); His3-(26-32)-peptide (His3 26/32) (His3-(7-13)-peptide) (His3 7/13) (Histatin-3 7/13); His3-(26-31)-peptide (His3 26/31) (His3-(7-12)-peptide) (His3 7/12) (Histatin-3 7/12); His3-(26-30)-peptide (His3 26/30) (His3-(7-11)-peptide) (His3 7/11) (Histatin-3 7/11); His3-(31-51)-peptide (His3 31/51) (His3-(12-32)-peptide) (His3 12/32) (Histatin-3 12/32) (Histatin-4); His3-(31-44)-peptide (His3 31/44) (His3-(12-25)-peptide) (His3 12/25) (Histatin-3 12/25) (Histatin-9); His3-(31-43)-peptide (His3 31/43) (His3-(12-24)-peptide) (His3 12/24) (Histatin-3 12/24) (Histatin-7); His3-(32-44)-peptide (His3 32/44) (His3-(13-25)-peptide) (His3 13/25) (Histatin-10) (Histatin-3 13/25); His3-(32-43)-peptide (His3 32-43) (His3-(13-24)-peptide) (His3 13/24) (Histatin-3 13/24) (Histatin-8); His3-(33-44)-peptide (His3 33/44) (His3-(14-25)-peptide) (His3 14/25) (Histatin-3 14/25); His3-(33-43)-peptide (His3 33/43) (His3-(14-24)-peptide) (His3 14/24) (Histatin-3 14/24); His3-(34-44)-peptide (His3 34/44) (His3-(15-25)-peptide) (His3 15/25) (Histatin-3 15/25); His3-(34-43)-peptide (His3 34/43) (His3-(15-24)-peptide) (His3 15/24) (Histatin-3 15/24); His3-(45-51)-peptide (His3 45/51) (His3-(26-32)-peptide) (His3 26/32) (Histatin-3 26/32); His3-(47-51)-peptide (His3 47/51) (His3-(28-32)-peptide) (His3 28/32) (Histatin-3 28/32); His3-(48-51)-peptide (His3 48/51) (His3-(29-32)-peptide) (His3 29/32) (Histatin-3 29/32)]	HTN3 HIS2	Homo sapiens (Human)	51	FUNCTION: Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9. {ECO:0000269|PubMed:11179305, ECO:0000269|PubMed:8945538}.	MISCELLANEOUS: The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions within the precursor, and not in the mature protein, as has formerly been proposed. {ECO:0000305|PubMed:20973643}.	biomineral tissue development [GO:0031214]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; killing of cells of another organism [GO:0031640]	extracellular region [GO:0005576]	metal ion binding [GO:0046872]	extracellular region [GO:0005576]; metal ion binding [GO:0046872]; biomineral tissue development [GO:0031214]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; killing of cells of another organism [GO:0031640]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14966203}. Note=Secreted by serous acinar and demilune cells.
P15529	reviewed	MCP_HUMAN	Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)	CD46 MCP MIC10	Homo sapiens (Human)	392	FUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. {ECO:0000269|PubMed:10843656, ECO:0000269|PubMed:12540904}.; FUNCTION: (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.; FUNCTION: (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. {ECO:0000269|PubMed:12915534, ECO:0000269|PubMed:14566335, ECO:0000269|PubMed:15047806, ECO:0000269|PubMed:15078926, ECO:0000269|PubMed:15919905, ECO:0000269|PubMed:16254377}.; FUNCTION: (Microbial infection) Acts as a receptor for cultured Measles virus. {ECO:0000269|PubMed:10972291}.; FUNCTION: (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. {ECO:0000269|PubMed:12663806, ECO:0000269|PubMed:12724329}.; FUNCTION: (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).		adaptive immune response [GO:0002250]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, classical pathway [GO:0045959]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of Notch signaling pathway [GO:0008593]; sequestering of extracellular ligand from receptor [GO:0035581]; single fertilization [GO:0007338]; T cell mediated immunity [GO:0002456]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; inner acrosomal membrane [GO:0002079]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; inner acrosomal membrane [GO:0002079]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618]; adaptive immune response [GO:0002250]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, classical pathway [GO:0045959]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of Notch signaling pathway [GO:0008593]; sequestering of extracellular ligand from receptor [GO:0035581]; single fertilization [GO:0007338]; T cell mediated immunity [GO:0002456]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane {ECO:0000269|PubMed:12112588, ECO:0000269|PubMed:14597734, ECO:0000269|PubMed:15307194}; Single-pass type I membrane protein {ECO:0000269|PubMed:12112588, ECO:0000269|PubMed:14597734, ECO:0000269|PubMed:15307194}. Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.
P15531	reviewed	NDKA_HUMAN	Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)	NME1 NDPKA NM23	Homo sapiens (Human)	152	FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}.	MISCELLANEOUS: The role of this protein in tumor development and progression is uncertain. This protein is found in reduced amount in some tumor cells of high metastatic potential. However, increased NME1 levels correlate with aggressive tumor features in neuroblastoma. May have distinct if not opposite roles in different tumors.	cell differentiation [GO:0030154]; CTP biosynthetic process [GO:0006241]; endocytosis [GO:0006897]; GTP biosynthetic process [GO:0006183]; lactation [GO:0007595]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; positive regulation of DNA binding [GO:0043388]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of apoptotic process [GO:0042981]; UTP biosynthetic process [GO:0006228]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]	ATP binding [GO:0005524]; DNA nuclease activity [GO:0004536]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleoside diphosphate kinase activity [GO:0004550]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; ATP binding [GO:0005524]; DNA nuclease activity [GO:0004536]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleoside diphosphate kinase activity [GO:0004550]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; cell differentiation [GO:0030154]; CTP biosynthetic process [GO:0006241]; endocytosis [GO:0006897]; GTP biosynthetic process [GO:0006183]; lactation [GO:0007595]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; positive regulation of DNA binding [GO:0043388]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of apoptotic process [GO:0042981]; UTP biosynthetic process [GO:0006228]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16442775}. Nucleus {ECO:0000269|PubMed:16442775}. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
P15538	reviewed	C11B1_HUMAN	Cytochrome P450 11B1, mitochondrial (CYP11B1) (CYPXIB1) (Cytochrome P-450c11) (Cytochrome P450C11) (Steroid 11-beta-hydroxylase, CYP11B1) (EC 1.14.15.4)	CYP11B1 S11BH	Homo sapiens (Human)	503	FUNCTION: A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PubMed:1775135, PubMed:1518866, PubMed:12530636, PubMed:18215163, PubMed:23322723). Catalyzes a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19 (By similarity). Catalyzes the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone (PubMed:18215163, PubMed:1518866, PubMed:1775135, PubMed:12530636, PubMed:23322723). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:18215163). Due to its lack of 18-oxidation activity, it is incapable of generating aldosterone (PubMed:23322723). Could also be involved in the androgen metabolic pathway (Probable). {ECO:0000250|UniProtKB:P15393, ECO:0000269|PubMed:12530636, ECO:0000269|PubMed:1518866, ECO:0000269|PubMed:1775135, ECO:0000269|PubMed:18215163, ECO:0000269|PubMed:23322723, ECO:0000305|PubMed:23322723}.		aldosterone biosynthetic process [GO:0032342]; C21-steroid hormone biosynthetic process [GO:0006700]; cellular response to hormone stimulus [GO:0032870]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to potassium ion [GO:0035865]; cholesterol metabolic process [GO:0008203]; cortisol biosynthetic process [GO:0034651]; cortisol metabolic process [GO:0034650]; glucocorticoid biosynthetic process [GO:0006704]; glucose homeostasis [GO:0042593]; immune response [GO:0006955]; regulation of blood pressure [GO:0008217]; sterol metabolic process [GO:0016125]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	corticosterone 18-monooxygenase activity [GO:0047783]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 11-beta-monooxygenase activity [GO:0004507]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; corticosterone 18-monooxygenase activity [GO:0047783]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 11-beta-monooxygenase activity [GO:0004507]; aldosterone biosynthetic process [GO:0032342]; C21-steroid hormone biosynthetic process [GO:0006700]; cellular response to hormone stimulus [GO:0032870]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to potassium ion [GO:0035865]; cholesterol metabolic process [GO:0008203]; cortisol biosynthetic process [GO:0034651]; cortisol metabolic process [GO:0034650]; glucocorticoid biosynthetic process [GO:0006704]; glucose homeostasis [GO:0042593]; immune response [GO:0006955]; regulation of blood pressure [GO:0008217]; sterol metabolic process [GO:0016125]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P14137}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14137}.
P15559	reviewed	NQO1_HUMAN	NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1)	NQO1 DIA4 NMOR1	Homo sapiens (Human)	274	FUNCTION: Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (PubMed:8999809, PubMed:9271353) (By similarity). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (PubMed:8999809, PubMed:9271353, PubMed:15102952). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (PubMed:8999809). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (PubMed:15687255, PubMed:28291250). {ECO:0000250|UniProtKB:P05982, ECO:0000269|PubMed:15102952, ECO:0000269|PubMed:15687255, ECO:0000269|PubMed:28291250, ECO:0000269|PubMed:8999809, ECO:0000269|PubMed:9271353}.	MISCELLANEOUS: Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.	cell redox homeostasis [GO:0045454]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to metal ion [GO:0071248]; cellular response to oxidative stress [GO:0034599]; innate immune response [GO:0045087]; NADH oxidation [GO:0006116]; NADPH oxidation [GO:0070995]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of neuron apoptotic process [GO:0043525]; protein catabolic process [GO:0030163]; removal of superoxide radicals [GO:0019430]; response to alkaloid [GO:0043279]; response to amine [GO:0014075]; response to carbohydrate [GO:0009743]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to flavonoid [GO:1905395]; response to hormone [GO:0009725]; response to hydrogen sulfide [GO:1904880]; response to ischemia [GO:0002931]; response to L-glutamine [GO:1904844]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to testosterone [GO:0033574]; response to tetrachloromethane [GO:1904772]; response to toxic substance [GO:0009636]; synaptic transmission, cholinergic [GO:0007271]; ubiquinone metabolic process [GO:0006743]; vitamin E metabolic process [GO:0042360]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synapse [GO:0045202]	cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; identical protein binding [GO:0042802]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADH dehydrogenase (quinone) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; RNA binding [GO:0003723]; superoxide dismutase activity [GO:0004784]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synapse [GO:0045202]; cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; identical protein binding [GO:0042802]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADH dehydrogenase (quinone) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; RNA binding [GO:0003723]; superoxide dismutase activity [GO:0004784]; cell redox homeostasis [GO:0045454]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to metal ion [GO:0071248]; cellular response to oxidative stress [GO:0034599]; innate immune response [GO:0045087]; NADH oxidation [GO:0006116]; NADPH oxidation [GO:0070995]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of neuron apoptotic process [GO:0043525]; protein catabolic process [GO:0030163]; removal of superoxide radicals [GO:0019430]; response to alkaloid [GO:0043279]; response to amine [GO:0014075]; response to carbohydrate [GO:0009743]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to flavonoid [GO:1905395]; response to hormone [GO:0009725]; response to hydrogen sulfide [GO:1904880]; response to ischemia [GO:0002931]; response to L-glutamine [GO:1904844]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to testosterone [GO:0033574]; response to tetrachloromethane [GO:1904772]; response to toxic substance [GO:0009636]; synaptic transmission, cholinergic [GO:0007271]; ubiquinone metabolic process [GO:0006743]; vitamin E metabolic process [GO:0042360]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P05982}.
P15586	reviewed	GNS_HUMAN	N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S)	GNS	Homo sapiens (Human)	552			glycosaminoglycan catabolic process [GO:0006027]; keratan sulfate catabolic process [GO:0042340]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]	glycosaminoglycan binding [GO:0005539]; metal ion binding [GO:0046872]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]; sulfate binding [GO:0043199]; sulfuric ester hydrolase activity [GO:0008484]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; glycosaminoglycan binding [GO:0005539]; metal ion binding [GO:0046872]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]; sulfate binding [GO:0043199]; sulfuric ester hydrolase activity [GO:0008484]; glycosaminoglycan catabolic process [GO:0006027]; keratan sulfate catabolic process [GO:0042340]	SUBCELLULAR LOCATION: Lysosome.
P15622	reviewed	ZN250_HUMAN	Zinc finger protein 250 (Zinc finger protein 647)	ZNF250 ZNF647	Homo sapiens (Human)	560	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P15692	reviewed	VEGFA_HUMAN	Vascular endothelial growth factor A, long form (L-VEGF) (Vascular permeability factor) (VPF) [Cleaved into: N-VEGF; VEGFA]	VEGFA VEGF	Homo sapiens (Human)	395	FUNCTION: [N-VEGF]: Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (By similarity). {ECO:0000250|UniProtKB:Q00731, ECO:0000269|PubMed:35455969}.; FUNCTION: [VEGFA]: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). {ECO:0000250|UniProtKB:Q00731, ECO:0000269|PubMed:11427521, ECO:0000269|PubMed:16489009, ECO:0000269|PubMed:17446437, ECO:0000269|PubMed:25825981}.; FUNCTION: [Isoform VEGF165B]: Binds to the KDR receptor but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. {ECO:0000269|PubMed:15520188}.	MISCELLANEOUS: [Isoform L-VEGF189]: Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon.; MISCELLANEOUS: [Isoform L-VEGF165]: Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon.; MISCELLANEOUS: [Isoform L-VEGF121]: Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon.; MISCELLANEOUS: [Isoform L-VEGF206]: Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon. {ECO:0000305}.; MISCELLANEOUS: [Isoform 15]: Starts at an alternative upstream CUG codon. {ECO:0000305}.; MISCELLANEOUS: [Isoform 16]: Starts at an alternative upstream CUG codon. {ECO:0000305}.; MISCELLANEOUS: [Isoform 17]: Starts at an alternative upstream CUG codon. {ECO:0000305}.; MISCELLANEOUS: [Isoform 18]: Starts at an alternative upstream CUG codon. {ECO:0000305}.	activation of protein kinase activity [GO:0032147]; angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; basophil chemotaxis [GO:0002575]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye morphogenesis [GO:0048593]; cardiac muscle cell development [GO:0055013]; cardiac vascular smooth muscle cell development [GO:0060948]; cell maturation [GO:0048469]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to hypoxia [GO:0071456]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular stress response to acid chemical [GO:0097533]; commissural neuron axon guidance [GO:0071679]; coronary artery morphogenesis [GO:0060982]; coronary vein morphogenesis [GO:0003169]; dopaminergic neuron differentiation [GO:0071542]; endothelial cell chemotaxis [GO:0035767]; epithelial cell differentiation [GO:0030855]; eye photoreceptor cell development [GO:0042462]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; induction of positive chemotaxis [GO:0050930]; kidney development [GO:0001822]; lactation [GO:0007595]; lung development [GO:0030324]; lymph vessel morphogenesis [GO:0036303]; macrophage differentiation [GO:0030225]; mammary gland alveolus development [GO:0060749]; mesoderm development [GO:0007498]; monocyte differentiation [GO:0030224]; motor neuron migration [GO:0097475]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of establishment of endothelial barrier [GO:1903141]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; outflow tract morphogenesis [GO:0003151]; ovarian follicle development [GO:0001541]; positive chemotaxis [GO:0050918]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration by vascular endothelial growth factor signaling pathway [GO:0038089]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor internalization [GO:0002092]; positive regulation of retinal ganglion cell axon guidance [GO:1902336]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of trophoblast cell migration [GO:1901165]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; positive regulation of vascular permeability [GO:0043117]; post-embryonic camera-type eye development [GO:0031077]; primitive erythrocyte differentiation [GO:0060319]; regulation of cell shape [GO:0008360]; regulation of nitric oxide mediated signal transduction [GO:0010749]; regulation of retinal ganglion cell axon guidance [GO:0090259]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; surfactant homeostasis [GO:0043129]; tube formation [GO:0035148]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; vascular endothelial growth factor signaling pathway [GO:0038084]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]; VEGF-activated neuropilin signaling pathway [GO:0038190]	adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; secretory granule [GO:0030141]; VEGF-A complex [GO:1990150]	chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; extracellular matrix binding [GO:0050840]; fibronectin binding [GO:0001968]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; neuropilin binding [GO:0038191]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; vascular endothelial growth factor receptor binding [GO:0005172]	adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; secretory granule [GO:0030141]; VEGF-A complex [GO:1990150]; chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; extracellular matrix binding [GO:0050840]; fibronectin binding [GO:0001968]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; neuropilin binding [GO:0038191]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; vascular endothelial growth factor receptor binding [GO:0005172]; activation of protein kinase activity [GO:0032147]; angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; basophil chemotaxis [GO:0002575]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye morphogenesis [GO:0048593]; cardiac muscle cell development [GO:0055013]; cardiac vascular smooth muscle cell development [GO:0060948]; cell maturation [GO:0048469]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to hypoxia [GO:0071456]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular stress response to acid chemical [GO:0097533]; commissural neuron axon guidance [GO:0071679]; coronary artery morphogenesis [GO:0060982]; coronary vein morphogenesis [GO:0003169]; dopaminergic neuron differentiation [GO:0071542]; endothelial cell chemotaxis [GO:0035767]; epithelial cell differentiation [GO:0030855]; eye photoreceptor cell development [GO:0042462]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; induction of positive chemotaxis [GO:0050930]; kidney development [GO:0001822]; lactation [GO:0007595]; lung development [GO:0030324]; lymph vessel morphogenesis [GO:0036303]; macrophage differentiation [GO:0030225]; mammary gland alveolus development [GO:0060749]; mesoderm development [GO:0007498]; monocyte differentiation [GO:0030224]; motor neuron migration [GO:0097475]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of establishment of endothelial barrier [GO:1903141]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; outflow tract morphogenesis [GO:0003151]; ovarian follicle development [GO:0001541]; positive chemotaxis [GO:0050918]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration by vascular endothelial growth factor signaling pathway [GO:0038089]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor internalization [GO:0002092]; positive regulation of retinal ganglion cell axon guidance [GO:1902336]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of trophoblast cell migration [GO:1901165]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; positive regulation of vascular permeability [GO:0043117]; post-embryonic camera-type eye development [GO:0031077]; primitive erythrocyte differentiation [GO:0060319]; regulation of cell shape [GO:0008360]; regulation of nitric oxide mediated signal transduction [GO:0010749]; regulation of retinal ganglion cell axon guidance [GO:0090259]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; surfactant homeostasis [GO:0043129]; tube formation [GO:0035148]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; vascular endothelial growth factor signaling pathway [GO:0038084]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]; VEGF-activated neuropilin signaling pathway [GO:0038190]	SUBCELLULAR LOCATION: [N-VEGF]: Cytoplasm {ECO:0000269|PubMed:15896327}. Nucleus {ECO:0000269|PubMed:15896327, ECO:0000269|PubMed:35455969}. Note=Cytoplasmic in normoxic conditions and localizes to the nucleus under hypoxic conditions. {ECO:0000269|PubMed:15896327, ECO:0000269|PubMed:35455969}.; SUBCELLULAR LOCATION: [VEGFA]: Secreted {ECO:0000269|PubMed:11563986, ECO:0000269|PubMed:11731620, ECO:0000269|PubMed:15896327}.; SUBCELLULAR LOCATION: [Isoform L-VEGF189]: Endoplasmic reticulum {ECO:0000269|PubMed:11731620}. Golgi apparatus {ECO:0000269|PubMed:11731620}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11563986}.; SUBCELLULAR LOCATION: [Isoform VEGF121]: Secreted {ECO:0000269|PubMed:15896327}.; SUBCELLULAR LOCATION: [Isoform VEGF165]: Secreted {ECO:0000269|PubMed:15896327}.; SUBCELLULAR LOCATION: [Isoform VEGF189]: Secreted. Note=Cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
P15735	reviewed	PHKG2_HUMAN	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2)	PHKG2	Homo sapiens (Human)	406	FUNCTION: Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity). {ECO:0000250, ECO:0000269|PubMed:10487978}.		generation of precursor metabolites and energy [GO:0006091]; glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; positive regulation of glycogen catabolic process [GO:0045819]; protein phosphorylation [GO:0006468]	cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; phosphorylase kinase activity [GO:0004689]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]	cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; phosphorylase kinase activity [GO:0004689]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]; generation of precursor metabolites and energy [GO:0006091]; glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; positive regulation of glycogen catabolic process [GO:0045819]; protein phosphorylation [GO:0006468]	
P15812	reviewed	CD1E_HUMAN	T-cell surface glycoprotein CD1e, membrane-associated (hCD1e) (R2G1) (CD antigen CD1e) [Cleaved into: T-cell surface glycoprotein CD1e, soluble (sCD1e)]	CD1E	Homo sapiens (Human)	388	FUNCTION: T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. {ECO:0000269|PubMed:10948205, ECO:0000269|PubMed:16311334, ECO:0000269|PubMed:21788486}.		adaptive immune response [GO:0002250]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipopeptide binding [GO:0071723]	early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipopeptide binding [GO:0071723]; adaptive immune response [GO:0002250]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	SUBCELLULAR LOCATION: [T-cell surface glycoprotein CD1e, membrane-associated]: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.; SUBCELLULAR LOCATION: [T-cell surface glycoprotein CD1e, soluble]: Lysosome lumen.
P15813	reviewed	CD1D_HUMAN	Antigen-presenting glycoprotein CD1d (R3G1) (CD antigen CD1d)	CD1D	Homo sapiens (Human)	335	FUNCTION: Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:17475845}.	MISCELLANEOUS: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface. {ECO:0000250}.	antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; detection of bacterium [GO:0016045]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; T cell selection [GO:0045058]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	beta-2-microglobulin binding [GO:0030881]; cell adhesion molecule binding [GO:0050839]; endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; histone binding [GO:0042393]; lipid antigen binding [GO:0030882]; lipopeptide binding [GO:0071723]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; beta-2-microglobulin binding [GO:0030881]; cell adhesion molecule binding [GO:0050839]; endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; histone binding [GO:0042393]; lipid antigen binding [GO:0030882]; lipopeptide binding [GO:0071723]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; detection of bacterium [GO:0016045]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; T cell selection [GO:0045058]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11927549, ECO:0000269|PubMed:17475845, ECO:0000269|PubMed:9973405}; Single-pass type I membrane protein {ECO:0000305|PubMed:9973405}. Basolateral cell membrane {ECO:0000269|PubMed:9973405}; Single-pass type I membrane protein {ECO:0000305|PubMed:9973405}. Endosome membrane {ECO:0000269|PubMed:11927549, ECO:0000269|PubMed:9973405}; Single-pass type I membrane protein {ECO:0000305|PubMed:9973405}. Lysosome membrane {ECO:0000269|PubMed:17475845, ECO:0000269|PubMed:9973405}; Single-pass type I membrane protein {ECO:0000269|PubMed:9973405}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11927549}; Single-pass type I membrane protein {ECO:0000269|PubMed:11927549}. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. {ECO:0000269|PubMed:9973405}.
P15814	reviewed	IGLL1_HUMAN	Immunoglobulin lambda-like polypeptide 1 (CD179 antigen-like family member B) (Ig lambda-5) (Immunoglobulin omega polypeptide) (Immunoglobulin-related protein 14.1) (CD antigen CD179b)	IGLL1 IGL1	Homo sapiens (Human)	213	FUNCTION: Critical for B-cell development. {ECO:0000269|PubMed:9419212}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; IgG immunoglobulin complex [GO:0071735]; membrane [GO:0016020]	antigen binding [GO:0003823]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; IgG immunoglobulin complex [GO:0071735]; membrane [GO:0016020]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:P20764}. Secreted {ECO:0000269|PubMed:9419212}. Note=In pre-B cells, localizes predominantly to the endoplasmic reticulum. {ECO:0000250|UniProtKB:P20764}.
P15822	reviewed	ZEP1_HUMAN	Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1)	HIVEP1 ZNF40	Homo sapiens (Human)	2718	FUNCTION: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.		BMP signaling pathway [GO:0030509]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; BMP signaling pathway [GO:0030509]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|Ref.2}. Nucleus {ECO:0000269|Ref.2}.
P15848	reviewed	ARSB_HUMAN	Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S)	ARSB	Homo sapiens (Human)	533	FUNCTION: Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). {ECO:0000250|UniProtKB:P50430, ECO:0000269|PubMed:19306108}.		autophagy [GO:0006914]; colon epithelial cell migration [GO:0061580]; lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268]	azurophil granule lumen [GO:0035578]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943]	azurophil granule lumen [GO:0035578]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943]; autophagy [GO:0006914]; colon epithelial cell migration [GO:0061580]; lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268]	SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P50429}. Cell surface {ECO:0000250|UniProtKB:P50429}.
P15863	reviewed	PAX1_HUMAN	Paired box protein Pax-1 (HuP48)	PAX1 HUP48	Homo sapiens (Human)	534	FUNCTION: This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity). {ECO:0000250}.		anatomical structure development [GO:0048856]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure development [GO:0048856]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
P15880	reviewed	RS2_HUMAN	Small ribosomal subunit protein uS5 (40S ribosomal protein S2) (40S ribosomal protein S4) (Protein LLRep3)	RPS2 RPS4	Homo sapiens (Human)	293	FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399). Plays a role in the assembly and function of the 40S ribosomal subunit (By similarity). Mutations in this protein affects the control of translational fidelity (By similarity). Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). {ECO:0000250|UniProtKB:P25443, ECO:0000269|PubMed:23636399}.		cytoplasmic translation [GO:0002181]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:30530495}. Nucleus, nucleolus {ECO:0000269|PubMed:30530495}. Note=Probably localized to nucleolus and cytoplasm in complex with ZNF277. {ECO:0000269|PubMed:30530495}.
P15882	reviewed	CHIN_HUMAN	N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2)	CHN1 ARHGAP2 CHN	Homo sapiens (Human)	459	FUNCTION: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.		ephrin receptor signaling pathway [GO:0048013]; motor neuron axon guidance [GO:0008045]; regulation of axonogenesis [GO:0050770]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytosol [GO:0005829]	ephrin receptor binding [GO:0046875]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; ephrin receptor binding [GO:0046875]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; ephrin receptor signaling pathway [GO:0048013]; motor neuron axon guidance [GO:0008045]; regulation of axonogenesis [GO:0050770]; regulation of small GTPase mediated signal transduction [GO:0051056]	
P15884	reviewed	ITF2_HUMAN	Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)	TCF4 BHLHB19 ITF2 SEF2	Homo sapiens (Human)	667	FUNCTION: Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}.		cell differentiation [GO:0030154]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex assembly [GO:0065004]; regulation of transcription by RNA polymerase II [GO:0006357]	beta-catenin-TCF complex [GO:1990907]; beta-catenin-TCF7L2 complex [GO:0070369]; chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; TFIIB-class transcription factor binding [GO:0001093]	beta-catenin-TCF complex [GO:1990907]; beta-catenin-TCF7L2 complex [GO:0070369]; chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; TFIIB-class transcription factor binding [GO:0001093]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex assembly [GO:0065004]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:22777675}.
P15907	reviewed	SIAT1_HUMAN	Beta-galactoside alpha-2,6-sialyltransferase 1 (Alpha 2,6-ST 1) (EC 2.4.3.1) (B-cell antigen CD75) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1) (ST6Gal I) (ST6GalI) (Sialyltransferase 1)	ST6GAL1 SIAT1	Homo sapiens (Human)	406	FUNCTION: Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. {ECO:0000269|PubMed:21081508, ECO:0000269|PubMed:23999306}.		humoral immune response [GO:0006959]; N-acetylneuraminate metabolic process [GO:0006054]; negative regulation of chemotaxis [GO:0050922]; negative regulation of macrophage apoptotic process [GO:2000110]; O-glycan processing [GO:0016266]; positive regulation of mononuclear cell proliferation [GO:0032946]; protein N-linked glycosylation via asparagine [GO:0018279]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; response to ethanol [GO:0045471]; sialylation [GO:0097503]; viral protein processing [GO:0019082]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]	beta-galactoside alpha-2,6-sialyltransferase activity [GO:0003835]; protein homodimerization activity [GO:0042803]; sialyltransferase activity [GO:0008373]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; beta-galactoside alpha-2,6-sialyltransferase activity [GO:0003835]; protein homodimerization activity [GO:0042803]; sialyltransferase activity [GO:0008373]; humoral immune response [GO:0006959]; N-acetylneuraminate metabolic process [GO:0006054]; negative regulation of chemotaxis [GO:0050922]; negative regulation of macrophage apoptotic process [GO:2000110]; O-glycan processing [GO:0016266]; positive regulation of mononuclear cell proliferation [GO:0032946]; protein N-linked glycosylation via asparagine [GO:0018279]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; response to ethanol [GO:0045471]; sialylation [GO:0097503]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:20378551}; Single-pass type II membrane protein {ECO:0000305}. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
P15918	reviewed	RAG1_HUMAN	V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74) [Includes: Endonuclease RAG1 (EC 3.1.-.-); E3 ubiquitin-protein ligase RAG1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RAG1)]	RAG1 RNF74	Homo sapiens (Human)	1043	FUNCTION: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. Mediates polyubiquitination of KPNA1 (By similarity). {ECO:0000250}.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; chromatin organization [GO:0006325]; DNA recombination [GO:0006310]; immune response [GO:0006955]; negative regulation of thymocyte apoptotic process [GO:0070244]; positive regulation of T cell differentiation [GO:0045582]; pre-B cell allelic exclusion [GO:0002331]; protein autoubiquitination [GO:0051865]; regulation of behavioral fear response [GO:2000822]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; V(D)J recombination [GO:0033151]; visual learning [GO:0008542]	DNA recombinase complex [GO:0097519]; endodeoxyribonuclease complex [GO:1905347]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	DNA recombinase complex [GO:0097519]; endodeoxyribonuclease complex [GO:1905347]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; chromatin organization [GO:0006325]; DNA recombination [GO:0006310]; immune response [GO:0006955]; negative regulation of thymocyte apoptotic process [GO:0070244]; positive regulation of T cell differentiation [GO:0045582]; pre-B cell allelic exclusion [GO:0002331]; protein autoubiquitination [GO:0051865]; regulation of behavioral fear response [GO:2000822]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; V(D)J recombination [GO:0033151]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00820}.
P15923	reviewed	TFE2_HUMAN	Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)	TCF3 BHLHB21 E2A ITF1	Homo sapiens (Human)	654	FUNCTION: Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}.	MISCELLANEOUS: [Isoform E47]: The bHLH domain encompassing amino acids 546 to 599 is sufficient to mediate DNA-binding and homodimerization. Combined mutagenesis of Phe-566 and Leu-569 to Asp-566 and Glu-569, mutagenesis of Lys-585 to Ala-585 or combined mutagenesis of Ile-588 and Leu-589 to Asp-588 and Glu-589 prevents DNA-binding and homodimerization. Mutagenesis of Arg-548 to Lys-548, combined mutagenesis of Arg-547 and Arg-548 to Gly-547 and Gly-548, mutagenesis of Arg-556 to Lys-556, mutagenesis of Arg-558 to Lys-558, or combined mutagenesis of Arg-556 and Arg-558 to Gly-556 and Gly-558, alter DNA-binding but not dimerization. {ECO:0000305}.	B cell differentiation [GO:0030183]; B cell lineage commitment [GO:0002326]; immunoglobulin V(D)J recombination [GO:0033152]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; vitamin D response element binding [GO:0070644]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]; bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; vitamin D response element binding [GO:0070644]; B cell differentiation [GO:0030183]; B cell lineage commitment [GO:0002326]; immunoglobulin V(D)J recombination [GO:0033152]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31696227}.
P15924	reviewed	DESP_HUMAN	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)	DSP	Homo sapiens (Human)	2871	FUNCTION: Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}.	MISCELLANEOUS: [Isoform DSPIa]: Minor isoform. {ECO:0000305}.	adherens junction organization [GO:0034332]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; epidermis development [GO:0008544]; epithelial cell-cell adhesion [GO:0090136]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; protein localization to cell-cell junction [GO:0150105]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; skin development [GO:0043588]; ventricular compact myocardium morphogenesis [GO:0003223]; wound healing [GO:0042060]	adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; fascia adherens [GO:0005916]; ficolin-1-rich granule membrane [GO:0101003]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]	adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; fascia adherens [GO:0005916]; ficolin-1-rich granule membrane [GO:0101003]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; adherens junction organization [GO:0034332]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; epidermis development [GO:0008544]; epithelial cell-cell adhesion [GO:0090136]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; protein localization to cell-cell junction [GO:0150105]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; skin development [GO:0043588]; ventricular compact myocardium morphogenesis [GO:0003223]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell junction, desmosome {ECO:0000250|UniProtKB:E9Q557}. Cell membrane {ECO:0000250|UniProtKB:E9Q557}. Note=Localizes at the intercalated disk in cardiomyocytes. {ECO:0000250|UniProtKB:E9Q557}.
P15927	reviewed	RFA2_HUMAN	Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)	RPA2 REPA2 RPA32 RPA34	Homo sapiens (Human)	270	FUNCTION: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. {ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}.		base-excision repair [GO:0006284]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; mismatch repair [GO:0006298]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; nucleotide-excision repair [GO:0006289]; protein localization to chromosome [GO:0034502]; regulation of DNA damage checkpoint [GO:2000001]; regulation of double-strand break repair via homologous recombination [GO:0010569]; telomere maintenance [GO:0000723]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; DNA replication factor A complex [GO:0005662]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	damaged DNA binding [GO:0003684]; enzyme binding [GO:0019899]; G-rich strand telomeric DNA binding [GO:0098505]; protein phosphatase binding [GO:0019903]; single-stranded DNA binding [GO:0003697]; telomeric DNA binding [GO:0042162]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; DNA replication factor A complex [GO:0005662]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; damaged DNA binding [GO:0003684]; enzyme binding [GO:0019899]; G-rich strand telomeric DNA binding [GO:0098505]; protein phosphatase binding [GO:0019903]; single-stranded DNA binding [GO:0003697]; telomeric DNA binding [GO:0042162]; ubiquitin protein ligase binding [GO:0031625]; base-excision repair [GO:0006284]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; mismatch repair [GO:0006298]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; nucleotide-excision repair [GO:0006289]; protein localization to chromosome [GO:0034502]; regulation of DNA damage checkpoint [GO:2000001]; regulation of double-strand break repair via homologous recombination [GO:0010569]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10982866, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906}. Nucleus, PML body {ECO:0000269|PubMed:12814551}. Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. {ECO:0000269|PubMed:12814551}.
P15941	reviewed	MUC1_HUMAN	Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]	MUC1 PUM	Homo sapiens (Human)	1255	FUNCTION: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.; FUNCTION: The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.	MISCELLANEOUS: The name KL-6 was originally that of a murine monoclonal antibody reacting with pulmonary adenocarcinoma cell lines and pulmonary epithelial cells. This antibody recognizes a sialylated carbohydrate chain on MUC1.; MISCELLANEOUS: [Isoform Y-LSP]: Lacks the mucin repeats. {ECO:0000305}.; MISCELLANEOUS: [Isoform ZD]: Lacks the mucin repeats. Exists as a disulfide-linked oligomer. {ECO:0000305}.	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; localization [GO:0051179]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of transcription by competitive promoter binding [GO:0010944]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; regulation of transcription from RNA polymerase II promoter in response to stress [GO:0043618]	apical plasma membrane [GO:0016324]; chromatin [GO:0000785]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	p53 binding [GO:0002039]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]	apical plasma membrane [GO:0016324]; chromatin [GO:0000785]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; p53 binding [GO:0002039]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; localization [GO:0051179]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of transcription by competitive promoter binding [GO:0010944]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; regulation of transcription from RNA polymerase II promoter in response to stress [GO:0043618]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}; Single-pass type I membrane protein {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform Y]: Secreted.; SUBCELLULAR LOCATION: [Isoform 9]: Secreted.; SUBCELLULAR LOCATION: [Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus.
P15954	reviewed	COX7C_HUMAN	Cytochrome c oxidase subunit 7C, mitochondrial (Cytochrome c oxidase polypeptide VIIc)	COX7C	Homo sapiens (Human)	63	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04039}.		cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
P15976	reviewed	GATA1_HUMAN	Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein)	GATA1 ERYF1 GF1	Homo sapiens (Human)	413	FUNCTION: Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). {ECO:0000269|PubMed:22235304, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:35030251}.	MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation at Met-84 of isoform 1. {ECO:0000305}.	animal organ regeneration [GO:0031100]; basophil differentiation [GO:0030221]; bone mineralization [GO:0030282]; cell fate commitment [GO:0045165]; cell-cell signaling [GO:0007267]; cellular response to cAMP [GO:0071320]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to thyroid hormone stimulus [GO:0097067]; dendritic cell differentiation [GO:0097028]; eosinophil differentiation [GO:0030222]; eosinophil fate commitment [GO:0035854]; erythrocyte development [GO:0048821]; erythrocyte differentiation [GO:0030218]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; male gonad development [GO:0008584]; megakaryocyte differentiation [GO:0030219]; myeloid cell apoptotic process [GO:0033028]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; osteoblast proliferation [GO:0033687]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive erythrocyte differentiation [GO:0060319]; regulation of definitive erythrocyte differentiation [GO:0010724]; regulation of glycoprotein biosynthetic process [GO:0010559]; regulation of primitive erythrocyte differentiation [GO:0010725]; Sertoli cell development [GO:0060009]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]	C2H2 zinc finger domain binding [GO:0070742]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; p53 binding [GO:0002039]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]; C2H2 zinc finger domain binding [GO:0070742]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; p53 binding [GO:0002039]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]; animal organ regeneration [GO:0031100]; basophil differentiation [GO:0030221]; bone mineralization [GO:0030282]; cell fate commitment [GO:0045165]; cell-cell signaling [GO:0007267]; cellular response to cAMP [GO:0071320]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to thyroid hormone stimulus [GO:0097067]; dendritic cell differentiation [GO:0097028]; eosinophil differentiation [GO:0030222]; eosinophil fate commitment [GO:0035854]; erythrocyte development [GO:0048821]; erythrocyte differentiation [GO:0030218]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; male gonad development [GO:0008584]; megakaryocyte differentiation [GO:0030219]; myeloid cell apoptotic process [GO:0033028]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; osteoblast proliferation [GO:0033687]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive erythrocyte differentiation [GO:0060319]; regulation of definitive erythrocyte differentiation [GO:0010724]; regulation of glycoprotein biosynthetic process [GO:0010559]; regulation of primitive erythrocyte differentiation [GO:0010725]; Sertoli cell development [GO:0060009]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35030251}.
P16035	reviewed	TIMP2_HUMAN	Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)	TIMP2	Homo sapiens (Human)	220	FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. {ECO:0000269|PubMed:11710594, ECO:0000269|PubMed:2554304, ECO:0000269|PubMed:2793861}.		negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of metallopeptidase activity [GO:1905049]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	metalloendopeptidase inhibitor activity [GO:0008191]; molecular function inhibitor activity [GO:0140678]; peptidase inhibitor activity [GO:0030414]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; metalloendopeptidase inhibitor activity [GO:0008191]; molecular function inhibitor activity [GO:0140678]; peptidase inhibitor activity [GO:0030414]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of metallopeptidase activity [GO:1905049]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]	SUBCELLULAR LOCATION: Secreted.
P16050	reviewed	LOX15_HUMAN	Polyunsaturated fatty acid lipoxygenase ALOX15 (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (EC 1.13.11.31) (Arachidonate 15-lipoxygenase) (15-LOX) (15-LOX-1) (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (Hepoxilin A3 synthase Alox15) (EC 1.13.11.-) (Linoleate 13S-lipoxygenase) (EC 1.13.11.12)	ALOX15 LOG15	Homo sapiens (Human)	662	FUNCTION: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:1944593, PubMed:8334154, PubMed:17052953, PubMed:24282679, PubMed:25293588, PubMed:32404334). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:1944593, PubMed:8334154, PubMed:17052953, PubMed:24282679). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (PubMed:8334154). May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (PubMed:25293588). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 (PubMed:21831839). {ECO:0000250|UniProtKB:P39654, ECO:0000250|UniProtKB:Q02759, ECO:0000269|PubMed:17052953, ECO:0000269|PubMed:1944593, ECO:0000269|PubMed:21831839, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:25293588, ECO:0000269|PubMed:32404334, ECO:0000269|PubMed:8334154}.		apoptotic cell clearance [GO:0043277]; arachidonic acid metabolic process [GO:0019369]; bone mineralization [GO:0030282]; cellular response to calcium ion [GO:0071277]; cellular response to interleukin-13 [GO:0035963]; fatty acid oxidation [GO:0019395]; hepoxilin biosynthetic process [GO:0051122]; inflammatory response [GO:0006954]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of adaptive immune response [GO:0002820]; ossification [GO:0001503]; phosphatidylethanolamine biosynthetic process [GO:0006646]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of engulfment of apoptotic cell [GO:1901074]; regulation of inflammatory response [GO:0050727]; regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358]; response to endoplasmic reticulum stress [GO:0034976]; wound healing [GO:0042060]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886]	arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 15-lipoxygenase activity [GO:0050473]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886]; arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 15-lipoxygenase activity [GO:0050473]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; apoptotic cell clearance [GO:0043277]; arachidonic acid metabolic process [GO:0019369]; bone mineralization [GO:0030282]; cellular response to calcium ion [GO:0071277]; cellular response to interleukin-13 [GO:0035963]; fatty acid oxidation [GO:0019395]; hepoxilin biosynthetic process [GO:0051122]; inflammatory response [GO:0006954]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of adaptive immune response [GO:0002820]; ossification [GO:0001503]; phosphatidylethanolamine biosynthetic process [GO:0006646]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of engulfment of apoptotic cell [GO:1901074]; regulation of inflammatory response [GO:0050727]; regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358]; response to endoplasmic reticulum stress [GO:0034976]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17052953, ECO:0000269|PubMed:21831839}. Cell membrane {ECO:0000269|PubMed:21831839}; Peripheral membrane protein {ECO:0000269|PubMed:17052953}. Lipid droplet {ECO:0000269|PubMed:19528634}. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding (By similarity). Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells (By similarity). {ECO:0000250|UniProtKB:P39654}.
P16066	reviewed	ANPRA_HUMAN	Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)	NPR1 ANPRA	Homo sapiens (Human)	1061	FUNCTION: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. {ECO:0000269|PubMed:1672777}.		blood vessel diameter maintenance [GO:0097746]; body fluid secretion [GO:0007589]; cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; dopamine metabolic process [GO:0042417]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of urine volume [GO:0035810]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; G protein-coupled peptide receptor activity [GO:0008528]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; G protein-coupled peptide receptor activity [GO:0008528]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]; blood vessel diameter maintenance [GO:0097746]; body fluid secretion [GO:0007589]; cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; dopamine metabolic process [GO:0042417]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of urine volume [GO:0035810]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P16070	reviewed	CD44_HUMAN	CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)	CD44 LHR MDU2 MDU3 MIC4	Homo sapiens (Human)	742	FUNCTION: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}.	MISCELLANEOUS: [Isoform 1]: Corresponds to the largest isoform.; MISCELLANEOUS: [Isoform 3]: Alternative splice donor/acceptor on exon 5. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Lacks exon 6. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Alternative splice donor/acceptor on exon 7. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Lacks exon 10. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Lacks exon 13. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Lacks exon 14. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Lacks exon 19. {ECO:0000305}.; MISCELLANEOUS: [Isoform 10]: Lacks exons 6-11. {ECO:0000305}.; MISCELLANEOUS: [Isoform 11]: Lacks exons 6-13. {ECO:0000305}.; MISCELLANEOUS: [Isoform 12]: Lacks exons 6-14. {ECO:0000305}.; MISCELLANEOUS: [Isoform 13]: Lacks exons 6-11 and exon 14. {ECO:0000305}.; MISCELLANEOUS: [Isoform 14]: Lacks exons 6-11, exon 13 and exon 14. {ECO:0000305}.; MISCELLANEOUS: [Isoform 15]: Lacks exons 6-14 and exon 19. {ECO:0000305}.; MISCELLANEOUS: [Isoform 16]: Alternative splice donor/acceptor on exon 5 and lacks exon 10. {ECO:0000305}.; MISCELLANEOUS: [Isoform 17]: Alternative splice donor/acceptor on exon 7 and lacks exon 10. {ECO:0000305}.; MISCELLANEOUS: [Isoform 19]: Soluble isoform, has enhanced hyaluronan binding. {ECO:0000305}.	cartilage development [GO:0051216]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cytokine-mediated signaling pathway [GO:0019221]; hyaluronan catabolic process [GO:0030214]; inflammatory response [GO:0006954]; monocyte aggregation [GO:0070487]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of monocyte aggregation [GO:1900625]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of lamellipodium morphogenesis [GO:2000392]; T cell activation [GO:0042110]; wound healing, spreading of cells [GO:0044319]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium membrane [GO:0031258]; macrophage migration inhibitory factor receptor complex [GO:0035692]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	collagen binding [GO:0005518]; hyaluronic acid binding [GO:0005540]; transmembrane signaling receptor activity [GO:0004888]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium membrane [GO:0031258]; macrophage migration inhibitory factor receptor complex [GO:0035692]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; collagen binding [GO:0005518]; hyaluronic acid binding [GO:0005540]; transmembrane signaling receptor activity [GO:0004888]; cartilage development [GO:0051216]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cytokine-mediated signaling pathway [GO:0019221]; hyaluronan catabolic process [GO:0030214]; inflammatory response [GO:0006954]; monocyte aggregation [GO:0070487]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of monocyte aggregation [GO:1900625]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of lamellipodium morphogenesis [GO:2000392]; T cell activation [GO:0042110]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P15379}. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313}. Note=Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. Localizes to cholesterol-rich membrane-bound lipid raft domains. {ECO:0000250|UniProtKB:P15379, ECO:0000269|PubMed:23589287}.
P16083	reviewed	NQO2_HUMAN	Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2)	NQO2 NMOR2	Homo sapiens (Human)	231	FUNCTION: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. {ECO:0000269|PubMed:18254726}.	MISCELLANEOUS: Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.	quinone catabolic process [GO:1901662]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	chloride ion binding [GO:0031404]; dihydronicotinamide riboside quinone reductase activity [GO:0001512]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; melatonin binding [GO:1904408]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; protein homodimerization activity [GO:0042803]; resveratrol binding [GO:1905594]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; chloride ion binding [GO:0031404]; dihydronicotinamide riboside quinone reductase activity [GO:0001512]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; melatonin binding [GO:1904408]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; protein homodimerization activity [GO:0042803]; resveratrol binding [GO:1905594]; zinc ion binding [GO:0008270]; quinone catabolic process [GO:1901662]	SUBCELLULAR LOCATION: Cytoplasm.
P16104	reviewed	H2AX_HUMAN	Histone H2AX (H2a/x) (Histone H2A.X)	H2AX H2AFX	Homo sapiens (Human)	143	FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:26438602}.		cellular response to gamma radiation [GO:0071480]; cellular senescence [GO:0090398]; cerebral cortex development [GO:0021987]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; meiotic cell cycle [GO:0051321]; nucleosome assembly [GO:0006334]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212]; spermatogenesis [GO:0007283]	centrosome [GO:0005813]; condensed nuclear chromosome [GO:0000794]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; XY body [GO:0001741]	damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	centrosome [GO:0005813]; condensed nuclear chromosome [GO:0000794]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; XY body [GO:0001741]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; cellular response to gamma radiation [GO:0071480]; cellular senescence [GO:0090398]; cerebral cortex development [GO:0021987]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; meiotic cell cycle [GO:0051321]; nucleosome assembly [GO:0006334]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12660252, ECO:0000269|PubMed:12697768, ECO:0000269|PubMed:15613478, ECO:0000269|PubMed:24429368}. Chromosome {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12660252, ECO:0000269|PubMed:15059890, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15613478}.
P16109	reviewed	LYAM3_HUMAN	P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)	SELP GMRP GRMP	Homo sapiens (Human)	830	FUNCTION: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. {ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:28011641, ECO:0000269|PubMed:7585950}.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell adhesion [GO:0007155]; defense response to Gram-negative bacterium [GO:0050829]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; regulation of integrin activation [GO:0033623]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; platelet dense granule membrane [GO:0031088]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; fucose binding [GO:0042806]; glycosphingolipid binding [GO:0043208]; heparin binding [GO:0008201]; lipopolysaccharide binding [GO:0001530]; oligosaccharide binding [GO:0070492]; sialic acid binding [GO:0033691]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; platelet dense granule membrane [GO:0031088]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; fucose binding [GO:0042806]; glycosphingolipid binding [GO:0043208]; heparin binding [GO:0008201]; lipopolysaccharide binding [GO:0001530]; oligosaccharide binding [GO:0070492]; sialic acid binding [GO:0033691]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell adhesion [GO:0007155]; defense response to Gram-negative bacterium [GO:0050829]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; regulation of integrin activation [GO:0033623]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28011641}; Single-pass type I membrane protein {ECO:0000305|PubMed:28011641}.
P16112	reviewed	PGCA_HUMAN	Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2]	ACAN AGC1 CSPG1 MSK16	Homo sapiens (Human)	2530	FUNCTION: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.		cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; proteolysis [GO:0006508]; skeletal system development [GO:0001501]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; perineuronal net [GO:0072534]; synapse [GO:0045202]	carbohydrate binding [GO:0030246]; extracellular matrix structural constituent [GO:0005201]; hyaluronic acid binding [GO:0005540]; metal ion binding [GO:0046872]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; perineuronal net [GO:0072534]; synapse [GO:0045202]; carbohydrate binding [GO:0030246]; extracellular matrix structural constituent [GO:0005201]; hyaluronic acid binding [GO:0005540]; metal ion binding [GO:0046872]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; proteolysis [GO:0006508]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
P16118	reviewed	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase 1) (PFK/FBPase 1) (6PF-2-K/Fru-2,6-P2ase liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]	PFKFB1 F6PK PFRX	Homo sapiens (Human)	471	FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:2837207}.		animal organ regeneration [GO:0031100]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; response to cAMP [GO:0051591]; response to glucagon [GO:0033762]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; response to starvation [GO:0042594]	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex [GO:0043540]; cytosol [GO:0005829]	6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex [GO:0043540]; cytosol [GO:0005829]; 6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; animal organ regeneration [GO:0031100]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; response to cAMP [GO:0051591]; response to glucagon [GO:0033762]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; response to starvation [GO:0042594]	
P16144	reviewed	ITB4_HUMAN	Integrin beta-4 (GP150) (CD antigen CD104)	ITGB4	Homo sapiens (Human)	1822	FUNCTION: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.		autophagy [GO:0006914]; cell adhesion [GO:0007155]; cell motility [GO:0048870]; cell-matrix adhesion [GO:0007160]; filopodium assembly [GO:0046847]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229]; mesodermal cell differentiation [GO:0048333]; nail development [GO:0035878]; peripheral nervous system myelin formation [GO:0032290]; response to wounding [GO:0009611]; skin morphogenesis [GO:0043589]; trophoblast cell migration [GO:0061450]	basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; integrin complex [GO:0008305]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled receptor binding [GO:0001664]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]	basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; integrin complex [GO:0008305]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled receptor binding [GO:0001664]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; autophagy [GO:0006914]; cell adhesion [GO:0007155]; cell motility [GO:0048870]; cell-matrix adhesion [GO:0007160]; filopodium assembly [GO:0046847]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229]; mesodermal cell differentiation [GO:0048333]; nail development [GO:0035878]; peripheral nervous system myelin formation [GO:0032290]; response to wounding [GO:0009611]; skin morphogenesis [GO:0043589]; trophoblast cell migration [GO:0061450]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes.
P16150	reviewed	LEUK_HUMAN	Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]	SPN CD43	Homo sapiens (Human)	400	FUNCTION: Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity). {ECO:0000250|UniProtKB:P15702, ECO:0000269|PubMed:18036228, ECO:0000269|PubMed:24328034}.; FUNCTION: [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival. {ECO:0000250|UniProtKB:P15702}.		apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; establishment or maintenance of cell polarity [GO:0007163]; immune response [GO:0006955]; leukocyte tethering or rolling [GO:0050901]; negative regulation of cell adhesion [GO:0007162]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type IV hypersensitivity [GO:0001808]; negative thymic T cell selection [GO:0045060]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of defense response to virus [GO:0050688]; regulation of immune response [GO:0050776]; regulation of T cell migration [GO:2000404]; response to protozoan [GO:0001562]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]; T-helper 1 cell lineage commitment [GO:0002296]	basement membrane [GO:0005604]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; PML body [GO:0016605]; uropod [GO:0001931]	heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; transmembrane signaling receptor activity [GO:0004888]	basement membrane [GO:0005604]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; PML body [GO:0016605]; uropod [GO:0001931]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; transmembrane signaling receptor activity [GO:0004888]; apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; establishment or maintenance of cell polarity [GO:0007163]; immune response [GO:0006955]; leukocyte tethering or rolling [GO:0050901]; negative regulation of cell adhesion [GO:0007162]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type IV hypersensitivity [GO:0001808]; negative thymic T cell selection [GO:0045060]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of defense response to virus [GO:0050688]; regulation of immune response [GO:0050776]; regulation of T cell migration [GO:2000404]; response to protozoan [GO:0001562]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]; T-helper 1 cell lineage commitment [GO:0002296]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P13838}. Cell projection, uropodium {ECO:0000250|UniProtKB:P15702}. Note=Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). {ECO:0000250|UniProtKB:P13838, ECO:0000250|UniProtKB:P15702}.; SUBCELLULAR LOCATION: [CD43 cytoplasmic tail]: Nucleus {ECO:0000269|PubMed:15003504}. Nucleus, PML body {ECO:0000250|UniProtKB:P15702}. Note=The sumoylated form localizes to the PML body. {ECO:0000250|UniProtKB:P15702}.
P16152	reviewed	CBR1_HUMAN	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1)	CBR1 CBR CRN SDR21C1	Homo sapiens (Human)	277	FUNCTION: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:18449627, PubMed:15799708, PubMed:17912391, PubMed:7005231, PubMed:1921984, PubMed:17344335, PubMed:18826943). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:18826943, PubMed:17344335). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267). {ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943, ECO:0000269|PubMed:1921984, ECO:0000269|PubMed:28878267, ECO:0000269|PubMed:7005231}.		cyclooxygenase pathway [GO:0019371]; epithelial cell differentiation [GO:0030855]; glucocorticoid metabolic process [GO:0008211]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]	15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; carbonyl reductase (NADPH) activity [GO:0004090]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin-E2 9-reductase activity [GO:0050221]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; 15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; carbonyl reductase (NADPH) activity [GO:0004090]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin-E2 9-reductase activity [GO:0050221]; cyclooxygenase pathway [GO:0019371]; epithelial cell differentiation [GO:0030855]; glucocorticoid metabolic process [GO:0008211]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P16157	reviewed	ANK1_HUMAN	Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin)	ANK1 ANK	Homo sapiens (Human)	1881	FUNCTION: Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}.	MISCELLANEOUS: [Isoform Er1]: Major erythrocyte-specific isoform. Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform Er2]: Predominant form of minor erythrocyte-specific isoforms. Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er3]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er4]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er5]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er6]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er7]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er9]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er10]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er11]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er12]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er13]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er14]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er15]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Er16]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform Mu17]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform Mu18]: Produced by alternative splicing of isoform Mu17. {ECO:0000305}.; MISCELLANEOUS: [Isoform Mu19]: Produced by alternative splicing of isoform Mu17. {ECO:0000305}.; MISCELLANEOUS: [Isoform Mu20]: Produced by alternative splicing of isoform Mu17. {ECO:0000305}.; MISCELLANEOUS: [Isoform Br21]: Produced by alternative splicing of isoform Er1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 22]: Produced by alternative splicing. {ECO:0000305}.	cytoskeleton organization [GO:0007010]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein localization to plasma membrane [GO:0072659]; signal transduction [GO:0007165]	ankyrin-1 complex [GO:0170014]; axolemma [GO:0030673]; basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; M band [GO:0031430]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; spectrin-associated cytoskeleton [GO:0014731]; Z disc [GO:0030018]	ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; protein phosphatase binding [GO:0019903]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325]	ankyrin-1 complex [GO:0170014]; axolemma [GO:0030673]; basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; M band [GO:0031430]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; spectrin-associated cytoskeleton [GO:0014731]; Z disc [GO:0030018]; ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; protein phosphatase binding [GO:0019903]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325]; cytoskeleton organization [GO:0007010]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein localization to plasma membrane [GO:0072659]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform Er1]: Cytoplasm, cytoskeleton. Note=Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane.; SUBCELLULAR LOCATION: [Isoform Mu17]: Membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Colocalizes with OBSCN isoform 3/obscurin at the M line in differentiated skeletal muscle cells.; SUBCELLULAR LOCATION: [Isoform Mu18]: Sarcoplasmic reticulum {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform Mu19]: Sarcoplasmic reticulum {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform Mu20]: Sarcoplasmic reticulum {ECO:0000305}.
P16219	reviewed	ACADS_HUMAN	Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase)	ACADS	Homo sapiens (Human)	412	FUNCTION: Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:21237683, PubMed:11134486). {ECO:0000250|UniProtKB:P15651, ECO:0000269|PubMed:11134486, ECO:0000269|PubMed:21237683}.		butyrate catabolic process [GO:0046359]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]	centrosome [GO:0005813]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	acyl-CoA dehydrogenase activity [GO:0003995]; butyryl-CoA dehydrogenase activity [GO:0004085]; flavin adenine dinucleotide binding [GO:0050660]	centrosome [GO:0005813]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; acyl-CoA dehydrogenase activity [GO:0003995]; butyryl-CoA dehydrogenase activity [GO:0004085]; flavin adenine dinucleotide binding [GO:0050660]; butyrate catabolic process [GO:0046359]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q3ZBF6}.
P16220	reviewed	CREB1_HUMAN	Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1)	CREB1	Homo sapiens (Human)	327	FUNCTION: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity). {ECO:0000250|UniProtKB:P27925, ECO:0000250|UniProtKB:Q01147, ECO:0000269|PubMed:14536081}.	MISCELLANEOUS: [Isoform 3]: Highly expressed in adult testis and sperm. {ECO:0000305}.	axonogenesis [GO:0007409]; cAMP-mediated signaling [GO:0019933]; cellular response to forskolin [GO:1904322]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; cellular response to zinc ion [GO:0071294]; circadian rhythm [GO:0007623]; hormone secretion [GO:0046879]; lactation [GO:0007595]; lung saccule development [GO:0060430]; memory [GO:0007613]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by competitive promoter binding [GO:0010944]; osteoclast differentiation [GO:0030316]; pituitary gland development [GO:0021983]; positive regulation of cardiac muscle tissue development [GO:0055025]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hormone secretion [GO:0046887]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of cell size [GO:0008361]; regulation of testosterone biosynthetic process [GO:2000224]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucagon [GO:0033762]; response to organic substance [GO:0010033]; response to purine-containing compound [GO:0014074]; response to xenobiotic stimulus [GO:0009410]; secretory granule organization [GO:0033363]; signal transduction [GO:0007165]; type I pneumocyte differentiation [GO:0060509]	ATF4-CREB1 transcription factor complex [GO:1990589]; chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	cAMP response element binding [GO:0035497]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	ATF4-CREB1 transcription factor complex [GO:1990589]; chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; cAMP response element binding [GO:0035497]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; axonogenesis [GO:0007409]; cAMP-mediated signaling [GO:0019933]; cellular response to forskolin [GO:1904322]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; cellular response to zinc ion [GO:0071294]; circadian rhythm [GO:0007623]; hormone secretion [GO:0046879]; lactation [GO:0007595]; lung saccule development [GO:0060430]; memory [GO:0007613]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by competitive promoter binding [GO:0010944]; osteoclast differentiation [GO:0030316]; pituitary gland development [GO:0021983]; positive regulation of cardiac muscle tissue development [GO:0055025]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hormone secretion [GO:0046887]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of cell size [GO:0008361]; regulation of testosterone biosynthetic process [GO:2000224]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucagon [GO:0033762]; response to organic substance [GO:0010033]; response to purine-containing compound [GO:0014074]; response to xenobiotic stimulus [GO:0009410]; secretory granule organization [GO:0033363]; signal transduction [GO:0007165]; type I pneumocyte differentiation [GO:0060509]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00312, ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12552083}.
P16233	reviewed	LIPP_HUMAN	Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3)	PNLIP	Homo sapiens (Human)	465	FUNCTION: Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones. {ECO:0000269|PubMed:10769148, ECO:0000269|PubMed:17401110}.		intestinal cholesterol absorption [GO:0030299]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; positive regulation of triglyceride lipase activity [GO:0061365]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; lipase activity [GO:0016298]; metal ion binding [GO:0046872]; triglyceride lipase activity [GO:0004806]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; lipase activity [GO:0016298]; metal ion binding [GO:0046872]; triglyceride lipase activity [GO:0004806]; intestinal cholesterol absorption [GO:0030299]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; positive regulation of triglyceride lipase activity [GO:0061365]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25862608}.
P16234	reviewed	PGFRA_HUMAN	Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)	PDGFRA PDGFR2 RHEPDGFRA	Homo sapiens (Human)	1089	FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}.		adrenal gland development [GO:0030325]; cardiac myofibril assembly [GO:0055003]; cell activation [GO:0001775]; cell chemotaxis [GO:0060326]; cellular response to amino acid stimulus [GO:0071230]; cellular response to reactive oxygen species [GO:0034614]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic skeletal system morphogenesis [GO:0048704]; estrogen metabolic process [GO:0008210]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; hematopoietic progenitor cell differentiation [GO:0002244]; in utero embryonic development [GO:0001701]; Leydig cell differentiation [GO:0033327]; lung development [GO:0030324]; luteinization [GO:0001553]; male genitalia development [GO:0030539]; metanephric glomerular capillary formation [GO:0072277]; negative regulation of platelet activation [GO:0010544]; odontogenesis of dentin-containing tooth [GO:0042475]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-alpha signaling pathway [GO:0035790]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of chemotaxis [GO:0050921]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C activity [GO:0010863]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of mesenchymal stem cell differentiation [GO:2000739]; retina vasculature development in camera-type eye [GO:0061298]; roof of mouth development [GO:0060021]; signal transduction involved in regulation of gene expression [GO:0023019]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; white fat cell differentiation [GO:0050872]; wound healing [GO:0042060]	cell junction [GO:0030054]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; BBSome binding [GO:0062063]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021]	cell junction [GO:0030054]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; BBSome binding [GO:0062063]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021]; adrenal gland development [GO:0030325]; cardiac myofibril assembly [GO:0055003]; cell activation [GO:0001775]; cell chemotaxis [GO:0060326]; cellular response to amino acid stimulus [GO:0071230]; cellular response to reactive oxygen species [GO:0034614]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic skeletal system morphogenesis [GO:0048704]; estrogen metabolic process [GO:0008210]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; hematopoietic progenitor cell differentiation [GO:0002244]; in utero embryonic development [GO:0001701]; Leydig cell differentiation [GO:0033327]; lung development [GO:0030324]; luteinization [GO:0001553]; male genitalia development [GO:0030539]; metanephric glomerular capillary formation [GO:0072277]; negative regulation of platelet activation [GO:0010544]; odontogenesis of dentin-containing tooth [GO:0042475]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-alpha signaling pathway [GO:0035790]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of chemotaxis [GO:0050921]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C activity [GO:0010863]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of mesenchymal stem cell differentiation [GO:2000739]; retina vasculature development in camera-type eye [GO:0061298]; roof of mouth development [GO:0060021]; signal transduction involved in regulation of gene expression [GO:0023019]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; white fat cell differentiation [GO:0050872]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}; Single-pass type I membrane protein {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}. Cell projection, cilium {ECO:0000250|UniProtKB:P26618}. Golgi apparatus {ECO:0000250|UniProtKB:P26618}.
P16278	reviewed	BGAL_HUMAN	Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) (Elastin receptor 1)	GLB1 ELNR1	Homo sapiens (Human)	677	FUNCTION: [Isoform 1]: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. {ECO:0000269|PubMed:15714521, ECO:0000269|PubMed:19472408, ECO:0000269|PubMed:2511208, ECO:0000269|PubMed:25936995, ECO:0000269|PubMed:8200356}.; FUNCTION: [Isoform 2]: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers. {ECO:0000269|PubMed:10841810, ECO:0000269|PubMed:8922281}.		carbohydrate metabolic process [GO:0005975]; galactose catabolic process [GO:0019388]; glycosphingolipid metabolic process [GO:0006687]; heparan sulfate proteoglycan catabolic process [GO:0030200]; keratan sulfate catabolic process [GO:0042340]; response to cortisone [GO:0051413]; response to Thyroglobulin triiodothyronine [GO:1904016]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; perinuclear region of cytoplasm [GO:0048471]; vacuole [GO:0005773]	beta-galactosidase activity [GO:0004565]; galactoside binding [GO:0016936]; protein homodimerization activity [GO:0042803]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; perinuclear region of cytoplasm [GO:0048471]; vacuole [GO:0005773]; beta-galactosidase activity [GO:0004565]; galactoside binding [GO:0016936]; protein homodimerization activity [GO:0042803]; carbohydrate metabolic process [GO:0005975]; galactose catabolic process [GO:0019388]; glycosphingolipid metabolic process [GO:0006687]; heparan sulfate proteoglycan catabolic process [GO:0030200]; keratan sulfate catabolic process [GO:0042340]; response to cortisone [GO:0051413]; response to Thyroglobulin triiodothyronine [GO:1904016]	SUBCELLULAR LOCATION: [Isoform 1]: Lysosome {ECO:0000269|PubMed:2511208, ECO:0000269|PubMed:3084261}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:2511208}. Note=Localized to the perinuclear area of the cytoplasm but not to lysosomes. {ECO:0000269|PubMed:2511208}.
P16284	reviewed	PECA1_HUMAN	Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)	PECAM1	Homo sapiens (Human)	738	FUNCTION: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q08481, ECO:0000269|PubMed:12110892, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18672896, ECO:0000269|PubMed:19342684, ECO:0000269|PubMed:27958302}.; FUNCTION: [Isoform Delta15]: Does not protect against apoptosis. {ECO:0000269|PubMed:18388311}.		bicellular tight junction assembly [GO:0070830]; cell recognition [GO:0008037]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; diapedesis [GO:0050904]; establishment of endothelial barrier [GO:0061028]; glomerular endothelium development [GO:0072011]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; leukocyte cell-cell adhesion [GO:0007159]; maintenance of blood-brain barrier [GO:0035633]; monocyte extravasation [GO:0035696]; neutrophil extravasation [GO:0072672]; phagocytosis [GO:0006909]; positive regulation of cell migration [GO:0030335]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein localization to cell-cell junction [GO:0150107]; positive regulation of protein phosphorylation [GO:0001934]; signal transduction [GO:0007165]	cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; protein-containing complex [GO:0032991]; secretory granule membrane [GO:0030667]	protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888]	cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; protein-containing complex [GO:0032991]; secretory granule membrane [GO:0030667]; protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888]; bicellular tight junction assembly [GO:0070830]; cell recognition [GO:0008037]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; diapedesis [GO:0050904]; establishment of endothelial barrier [GO:0061028]; glomerular endothelium development [GO:0072011]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; leukocyte cell-cell adhesion [GO:0007159]; maintenance of blood-brain barrier [GO:0035633]; monocyte extravasation [GO:0035696]; neutrophil extravasation [GO:0072672]; phagocytosis [GO:0006909]; positive regulation of cell migration [GO:0030335]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein localization to cell-cell junction [GO:0150107]; positive regulation of protein phosphorylation [GO:0001934]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17580308}; Single-pass type I membrane protein {ECO:0000305}. Note=Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation. {ECO:0000269|PubMed:17580308}.; SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane {ECO:0000269|PubMed:18388311, ECO:0000269|PubMed:19342684}; Single-pass type I membrane protein {ECO:0000305|PubMed:18388311}. Membrane raft {ECO:0000269|PubMed:17139370, ECO:0000269|PubMed:22496122}. Cell junction {ECO:0000269|PubMed:18388311}. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. {ECO:0000269|PubMed:19342684}.; SUBCELLULAR LOCATION: [Isoform Delta15]: Cell junction {ECO:0000269|PubMed:18388311}. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
P16298	reviewed	PP2BB_HUMAN	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta)	PPP3CB CALNA2 CALNB CNA2	Homo sapiens (Human)	524	FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:32753672, PubMed:26794871). Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (PubMed:25720963, PubMed:32753672). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity). {ECO:0000250|UniProtKB:P48453, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:32753672}.	MISCELLANEOUS: Unlike for protein substrates, PPP3CB activity towards synthetic phosphatase substrate p-nitrophenyl phosphate (pNPP) is increased in presence of the immunosuppressant complex FKBP12-FK506. {ECO:0000269|PubMed:26794871}.	axon extension [GO:0048675]; calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; calcium-ion regulated exocytosis [GO:0017156]; dephosphorylation [GO:0016311]; heart development [GO:0007507]; learning [GO:0007612]; locomotion involved in locomotory behavior [GO:0031987]; lymphangiogenesis [GO:0001946]; memory [GO:0007613]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; negative regulation of signaling [GO:0023057]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of lysosome organization [GO:1905673]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein dephosphorylation [GO:0006470]; protein phosphorylation [GO:0006468]; regulation of insulin secretion [GO:0050796]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle endocytosis [GO:1900242]; response to cytokine [GO:0034097]; signal transduction [GO:0007165]; skeletal muscle fiber development [GO:0048741]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell homeostasis [GO:0043029]; T cell mediated cytotoxicity [GO:0001913]; T cell proliferation [GO:0042098]	calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein serine/threonine phosphatase complex [GO:0008287]; T-tubule [GO:0030315]; Z disc [GO:0030018]	calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; enzyme binding [GO:0019899]; myosin phosphatase activity [GO:0017018]; protein dimerization activity [GO:0046983]; protein phosphatase 2B binding [GO:0030346]; protein serine/threonine phosphatase activity [GO:0004722]	calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein serine/threonine phosphatase complex [GO:0008287]; T-tubule [GO:0030315]; Z disc [GO:0030018]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; enzyme binding [GO:0019899]; myosin phosphatase activity [GO:0017018]; protein dimerization activity [GO:0046983]; protein phosphatase 2B binding [GO:0030346]; protein serine/threonine phosphatase activity [GO:0004722]; axon extension [GO:0048675]; calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; calcium-ion regulated exocytosis [GO:0017156]; dephosphorylation [GO:0016311]; heart development [GO:0007507]; learning [GO:0007612]; locomotion involved in locomotory behavior [GO:0031987]; lymphangiogenesis [GO:0001946]; memory [GO:0007613]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; negative regulation of signaling [GO:0023057]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of lysosome organization [GO:1905673]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein dephosphorylation [GO:0006470]; protein phosphorylation [GO:0006468]; regulation of insulin secretion [GO:0050796]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle endocytosis [GO:1900242]; response to cytokine [GO:0034097]; signal transduction [GO:0007165]; skeletal muscle fiber development [GO:0048741]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell homeostasis [GO:0043029]; T cell mediated cytotoxicity [GO:0001913]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19154138}.
P16333	reviewed	NCK1_HUMAN	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha)	NCK1 NCK	Homo sapiens (Human)	377	FUNCTION: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}.		actin filament organization [GO:0007015]; antiviral innate immune response [GO:0140374]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; lamellipodium assembly [GO:0030032]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990441]; peptidyl-serine dephosphorylation [GO:0070262]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cap-dependent translational initiation [GO:1903676]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of neuron projection development [GO:0010976]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of cell migration [GO:0030334]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]; T cell activation [GO:0042110]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 1 complex [GO:0000164]; ribosome [GO:0005840]; vesicle membrane [GO:0012506]	cadherin binding [GO:0045296]; cytoskeletal anchor activity [GO:0008093]; ephrin receptor binding [GO:0046875]; eukaryotic initiation factor eIF2 binding [GO:0071074]; molecular condensate scaffold activity [GO:0140693]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; signaling receptor complex adaptor activity [GO:0030159]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 1 complex [GO:0000164]; ribosome [GO:0005840]; vesicle membrane [GO:0012506]; cadherin binding [GO:0045296]; cytoskeletal anchor activity [GO:0008093]; ephrin receptor binding [GO:0046875]; eukaryotic initiation factor eIF2 binding [GO:0071074]; molecular condensate scaffold activity [GO:0140693]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; signaling receptor complex adaptor activity [GO:0030159]; actin filament organization [GO:0007015]; antiviral innate immune response [GO:0140374]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; lamellipodium assembly [GO:0030032]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990441]; peptidyl-serine dephosphorylation [GO:0070262]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cap-dependent translational initiation [GO:1903676]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of neuron projection development [GO:0010976]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of cell migration [GO:0030334]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
P16383	reviewed	GCFC2_HUMAN	Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9)	GCFC2 C2orf3 GCF TCF9	Homo sapiens (Human)	781	FUNCTION: Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}.		mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; spliceosomal complex assembly [GO:0000245]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type post-mRNA release spliceosomal complex [GO:0071008]	DNA binding [GO:0003677]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type post-mRNA release spliceosomal complex [GO:0071008]; DNA binding [GO:0003677]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; spliceosomal complex assembly [GO:0000245]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:24304693}. Nucleus, nucleolus {ECO:0000269|PubMed:24304693}.
P16389	reviewed	KCNA2_HUMAN	Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2)	KCNA2	Homo sapiens (Human)	499	FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559, PubMed:11211111, PubMed:23769686). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559, PubMed:20220134). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:23769686). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity). {ECO:0000250|UniProtKB:P63141, ECO:0000250|UniProtKB:P63142, ECO:0000269|PubMed:11211111, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:20220134, ECO:0000269|PubMed:23769686, ECO:0000269|PubMed:8495559, ECO:0000305}.	MISCELLANEOUS: The delay or D-type current observed in hippocampus pyramidal neurons is probably mediated by potassium channels containing KCNA2 plus KCNA1 or other family members. It is activated at about -50 mV, i.e. below the action potential threshold, and is characterized by slow inactivation, extremely slow recovery from inactivation, sensitivity to dendrotoxin (DTX) and to 4-aminopyridine (4-AP). {ECO:0000305|PubMed:17917103}.	cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; neuronal action potential [GO:0019228]; optic nerve structural organization [GO:0021633]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of circadian sleep/wake cycle, non-REM sleep [GO:0045188]; regulation of dopamine secretion [GO:0014059]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sensory perception of pain [GO:0019233]	axon [GO:0030424]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; calyx of Held [GO:0044305]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; neuronal cell body membrane [GO:0032809]; paranodal junction [GO:0033010]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; kinesin binding [GO:0019894]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1905030]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]	axon [GO:0030424]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; calyx of Held [GO:0044305]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; neuronal cell body membrane [GO:0032809]; paranodal junction [GO:0033010]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; kinesin binding [GO:0019894]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1905030]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; neuronal action potential [GO:0019228]; optic nerve structural organization [GO:0021633]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of circadian sleep/wake cycle, non-REM sleep [GO:0045188]; regulation of dopamine secretion [GO:0014059]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sensory perception of pain [GO:0019233]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11211111, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:20220134, ECO:0000269|PubMed:23769686, ECO:0000269|PubMed:8495559}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P63142, ECO:0000305}. Membrane {ECO:0000250|UniProtKB:P63142}. Cell projection, axon {ECO:0000269|PubMed:16473933}. Synapse {ECO:0000250|UniProtKB:P63142}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P63142}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:P63142}. Synapse, synaptosome {ECO:0000250|UniProtKB:P63141}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P63141}. Cell projection, dendrite {ECO:0000250|UniProtKB:P63141}. Cell junction, paranodal septate junction {ECO:0000250|UniProtKB:P63141}. Note=KCNA2 by itself is detected both at the endoplasmic reticulum and at the cell membrane. Coexpression with KCNA4 or with beta subunits promotes expression at the cell membrane. Coexpression with KCNA1 inhibits cell surface expression. In myelinated peripheral axons, clustered in the juxtaparadonal region and at an internodal line located along the mesaxon and below the Schmidt-Lanterman incisures (By similarity). {ECO:0000250|UniProtKB:P63141, ECO:0000250|UniProtKB:P63142}.
P16401	reviewed	H15_HUMAN	Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)	H1-5 H1F5 HIST1H1B	Homo sapiens (Human)	226	FUNCTION: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.		chromatin organization [GO:0006325]; chromosome condensation [GO:0030261]; establishment of protein localization to chromatin [GO:0071169]; muscle organ development [GO:0007517]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]; protein stabilization [GO:0050821]	chromatin [GO:0000785]; chromosome [GO:0005694]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]	chromatin [GO:0000785]; chromosome [GO:0005694]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]; chromatin organization [GO:0006325]; chromosome condensation [GO:0030261]; establishment of protein localization to chromatin [GO:0071169]; muscle organ development [GO:0007517]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10997781, ECO:0000269|PubMed:15911621}. Chromosome. Note=Mainly localizes with heterochromatin (PubMed:15911621). Associates with actively transcribed chromatin and not heterochromatin (PubMed:10997781). {ECO:0000269|PubMed:10997781, ECO:0000269|PubMed:15911621}.
P16402	reviewed	H13_HUMAN	Histone H1.3 (Histone H1c) (Histone H1s-2)	H1-3 H1F3 HIST1H1D	Homo sapiens (Human)	221	FUNCTION: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.		chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]	chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleosome [GO:0000786]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]	chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleosome [GO:0000786]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]; chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in euchromatin. According to PubMed:10997781 is associated with inactive chromatin.
P16403	reviewed	H12_HUMAN	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	H1-2 H1F2 HIST1H1C	Homo sapiens (Human)	213	FUNCTION: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.		chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]	euchromatin [GO:0000791]; nucleosome [GO:0000786]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]	euchromatin [GO:0000791]; nucleosome [GO:0000786]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]; chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.
P16410	reviewed	CTLA4_HUMAN	Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152)	CTLA4 CD152	Homo sapiens (Human)	223	FUNCTION: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. {ECO:0000269|PubMed:16551244, ECO:0000269|PubMed:1714933}.	MISCELLANEOUS: The therapeutic antibody Ipilimumab competes for the binding site of the endogenous ligands CD80/B7-1, CD86/B7-2 and ICOSLG.	adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; DNA damage response [GO:0006974]; immune response [GO:0006955]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of regulatory T cell differentiation [GO:0045590]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of apoptotic process [GO:0043065]; T cell receptor signaling pathway [GO:0050852]	clathrin-coated endocytic vesicle [GO:0045334]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]		clathrin-coated endocytic vesicle [GO:0045334]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]; adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; DNA damage response [GO:0006974]; immune response [GO:0006955]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of regulatory T cell differentiation [GO:0045590]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of apoptotic process [GO:0043065]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18468488, ECO:0000269|PubMed:28484017}; Single-pass type I membrane protein {ECO:0000269|PubMed:18468488, ECO:0000269|PubMed:28484017}. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalization.
P16422	reviewed	EPCAM_HUMAN	Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)	EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1	Homo sapiens (Human)	314	FUNCTION: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. {ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:15922867, ECO:0000269|PubMed:19785009, ECO:0000269|PubMed:20064925}.		negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction involved in regulation of gene expression [GO:0023019]; stem cell differentiation [GO:0048863]; ureteric bud development [GO:0001657]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	cadherin binding involved in cell-cell adhesion [GO:0098641]; protein-containing complex binding [GO:0044877]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; cadherin binding involved in cell-cell adhesion [GO:0098641]; protein-containing complex binding [GO:0044877]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction involved in regulation of gene expression [GO:0023019]; stem cell differentiation [GO:0048863]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Lateral cell membrane {ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:16054130, ECO:0000269|PubMed:19785009}; Single-pass type I membrane protein {ECO:0000269|PubMed:16054130}. Cell junction, tight junction {ECO:0000269|PubMed:16054130}. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. {ECO:0000269|PubMed:16054130}.
P16435	reviewed	NCPR_HUMAN	NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4)	POR CYPOR	Homo sapiens (Human)	677	FUNCTION: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. {ECO:0000255|HAMAP-Rule:MF_03212}.		cellular organofluorine metabolic process [GO:0090346]; electron transport chain [GO:0022900]; positive regulation of monooxygenase activity [GO:0032770]; response to hormone [GO:0009725]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP binding [GO:0050661]; NADPH-hemoprotein reductase activity [GO:0003958]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP binding [GO:0050661]; NADPH-hemoprotein reductase activity [GO:0003958]; cellular organofluorine metabolic process [GO:0090346]; electron transport chain [GO:0022900]; positive regulation of monooxygenase activity [GO:0032770]; response to hormone [GO:0009725]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03212}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03212}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03212}.
P16442	reviewed	BGAT_HUMAN	Histo-blood group ABO system transferase (Fucosylglycoprotein 3-alpha-galactosyltransferase) (Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase) (Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase) (EC 2.4.1.40) (Glycoprotein-fucosylgalactoside alpha-galactosyltransferase) (EC 2.4.1.37) (Histo-blood group A transferase) (A transferase) (Histo-blood group B transferase) (B transferase) (NAGAT) [Cleaved into: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form]	ABO	Homo sapiens (Human)	354	FUNCTION: This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.		carbohydrate metabolic process [GO:0005975]; lipid glycosylation [GO:0030259]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; vesicle [GO:0031982]	antigen binding [GO:0003823]; fucosylgalactoside 3-alpha-galactosyltransferase activity [GO:0004381]; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity [GO:0004380]; manganese ion binding [GO:0030145]; nucleotide binding [GO:0000166]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; vesicle [GO:0031982]; antigen binding [GO:0003823]; fucosylgalactoside 3-alpha-galactosyltransferase activity [GO:0004381]; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity [GO:0004380]; manganese ion binding [GO:0030145]; nucleotide binding [GO:0000166]; carbohydrate metabolic process [GO:0005975]; lipid glycosylation [GO:0030259]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
P16444	reviewed	DPEP1_HUMAN	Dipeptidase 1 (EC 3.4.13.19) (Beta-lactamase) (EC 3.5.2.6) (Dehydropeptidase-I) (Microsomal dipeptidase) (Renal dipeptidase) (hRDP)	DPEP1 MDP RDP	Homo sapiens (Human)	411	FUNCTION: Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:6334084, PubMed:31442408, PubMed:32325220). Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (PubMed:32325220). Possesses also beta lactamase activity and can hydrolyze the beta-lactam antibiotic imipenem (PubMed:6334084, PubMed:32325220). {ECO:0000250|UniProtKB:P31428, ECO:0000269|PubMed:2303490, ECO:0000269|PubMed:31442408, ECO:0000269|PubMed:32325220, ECO:0000269|PubMed:6334084}.; FUNCTION: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver. {ECO:0000250|UniProtKB:P31428}.		antibiotic metabolic process [GO:0016999]; cellular response to calcium ion [GO:0071277]; cellular response to nitric oxide [GO:0071732]; cellular response to xenobiotic stimulus [GO:0071466]; glutathione catabolic process [GO:0006751]; glutathione metabolic process [GO:0006749]; homocysteine metabolic process [GO:0050667]; inflammatory response [GO:0006954]; lactam catabolic process [GO:0072340]; leukotriene D4 catabolic process [GO:1901749]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; neutrophil chemotaxis [GO:0030593]; proteolysis [GO:0006508]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	beta-lactamase activity [GO:0008800]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; dipeptidase activity [GO:0016805]; GPI anchor binding [GO:0034235]; metallodipeptidase activity [GO:0070573]; metalloexopeptidase activity [GO:0008235]; modified amino acid binding [GO:0072341]; zinc ion binding [GO:0008270]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; beta-lactamase activity [GO:0008800]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; dipeptidase activity [GO:0016805]; GPI anchor binding [GO:0034235]; metallodipeptidase activity [GO:0070573]; metalloexopeptidase activity [GO:0008235]; modified amino acid binding [GO:0072341]; zinc ion binding [GO:0008270]; antibiotic metabolic process [GO:0016999]; cellular response to calcium ion [GO:0071277]; cellular response to nitric oxide [GO:0071732]; cellular response to xenobiotic stimulus [GO:0071466]; glutathione catabolic process [GO:0006751]; glutathione metabolic process [GO:0006749]; homocysteine metabolic process [GO:0050667]; inflammatory response [GO:0006954]; lactam catabolic process [GO:0072340]; leukotriene D4 catabolic process [GO:1901749]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; neutrophil chemotaxis [GO:0030593]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:28413640}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2168407}. Cell projection, microvillus membrane {ECO:0000269|PubMed:2168407}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2168407}. Note=Brush border membrane. {ECO:0000250|UniProtKB:P31429}.
P16452	reviewed	EPB42_HUMAN	Protein 4.2 (P4.2) (Erythrocyte membrane protein band 4.2) (Erythrocyte protein 4.2)	EPB42 E42P	Homo sapiens (Human)	691	FUNCTION: Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. {ECO:0000269|PubMed:35835865}.	MISCELLANEOUS: The substitution of an Ala for a Cys in the active site may be responsible for the lack of transglutaminase activity of band 4.2.; MISCELLANEOUS: [Isoform Short]: Major isoform.	cell morphogenesis [GO:0000902]; erythrocyte maturation [GO:0043249]; hemoglobin metabolic process [GO:0020027]; multicellular organismal-level iron ion homeostasis [GO:0060586]; regulation of cell shape [GO:0008360]; spleen development [GO:0048536]	ankyrin-1 complex [GO:0170014]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; structural constituent of cytoskeleton [GO:0005200]	ankyrin-1 complex [GO:0170014]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; structural constituent of cytoskeleton [GO:0005200]; cell morphogenesis [GO:0000902]; erythrocyte maturation [GO:0043249]; hemoglobin metabolic process [GO:0020027]; multicellular organismal-level iron ion homeostasis [GO:0060586]; regulation of cell shape [GO:0008360]; spleen development [GO:0048536]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic surface of erythrocyte membranes.
P16455	reviewed	MGMT_HUMAN	Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)	MGMT	Homo sapiens (Human)	207	FUNCTION: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.	MISCELLANEOUS: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.	DNA dealkylation involved in DNA repair [GO:0006307]; DNA ligation [GO:0006266]; DNA repair [GO:0006281]; negative regulation of apoptotic process [GO:0043066]; positive regulation of double-strand break repair [GO:2000781]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-methyltransferase activity [GO:0009008]; metal ion binding [GO:0046872]; methylated-DNA-[protein]-cysteine S-methyltransferase activity [GO:0003908]; methyltransferase activity [GO:0008168]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-methyltransferase activity [GO:0009008]; metal ion binding [GO:0046872]; methylated-DNA-[protein]-cysteine S-methyltransferase activity [GO:0003908]; methyltransferase activity [GO:0008168]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA ligation [GO:0006266]; DNA repair [GO:0006281]; negative regulation of apoptotic process [GO:0043066]; positive regulation of double-strand break repair [GO:2000781]	SUBCELLULAR LOCATION: Nucleus.
P16471	reviewed	PRLR_HUMAN	Prolactin receptor (PRL-R)	PRLR	Homo sapiens (Human)	622	FUNCTION: This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269|PubMed:12580759, ECO:0000269|PubMed:20032052}.	MISCELLANEOUS: [Isoform 3]: Soluble isoform that appears specific for the BT-474 breast cancer cell line. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Includes exon 11. Does not transduce prolactin signaling. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by deletion of part of exon 10 and frameshift. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Does not transduce prolactin signaling. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Splices from exon 7 to exon 11. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: SF1b with deletion of exon 4. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	activation of Janus kinase activity [GO:0042976]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cytokine-mediated signaling pathway [GO:0019221]; embryo implantation [GO:0007566]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of apoptotic process [GO:0043066]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein autophosphorylation [GO:0031954]; prostate gland growth [GO:0060736]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell adhesion [GO:0030155]; regulation of epithelial cell differentiation [GO:0030856]; response to bacterium [GO:0009617]; steroid biosynthetic process [GO:0006694]	cell surface [GO:0009986]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; peptide hormone binding [GO:0017046]; prolactin receptor activity [GO:0004925]; protein kinase binding [GO:0019901]	cell surface [GO:0009986]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; peptide hormone binding [GO:0017046]; prolactin receptor activity [GO:0004925]; protein kinase binding [GO:0019901]; activation of Janus kinase activity [GO:0042976]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cytokine-mediated signaling pathway [GO:0019221]; embryo implantation [GO:0007566]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of apoptotic process [GO:0043066]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein autophosphorylation [GO:0031954]; prostate gland growth [GO:0060736]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell adhesion [GO:0030155]; regulation of epithelial cell differentiation [GO:0030856]; response to bacterium [GO:0009617]; steroid biosynthetic process [GO:0006694]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}; Single-pass type I membrane protein {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted.
P16473	reviewed	TSHR_HUMAN	Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)	TSHR LGR3	Homo sapiens (Human)	764	FUNCTION: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity). {ECO:0000250|UniProtKB:P21463, ECO:0000269|PubMed:11847099, ECO:0000269|PubMed:12045258}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to glycoprotein [GO:1904588]; cellular response to thyrotropin-releasing hormone [GO:1905229]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; thyroid-stimulating hormone signaling pathway [GO:0038194]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled peptide receptor activity [GO:0008528]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; thyroid-stimulating hormone receptor activity [GO:0004996]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled peptide receptor activity [GO:0008528]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; thyroid-stimulating hormone receptor activity [GO:0004996]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to glycoprotein [GO:1904588]; cellular response to thyrotropin-releasing hormone [GO:1905229]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; thyroid-stimulating hormone signaling pathway [GO:0038194]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11847099}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:11847099}; Multi-pass membrane protein {ECO:0000305}.
P16499	reviewed	PDE6A_HUMAN	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) (PDE V-B1)	PDE6A PDEA	Homo sapiens (Human)	860	FUNCTION: Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP (PubMed:20940301). This protein participates in processes of transmission and amplification of the visual signal. {ECO:0000269|PubMed:20940301}.		retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; visual perception [GO:0007601]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]	3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:20940301}.
P16519	reviewed	NEC2_HUMAN	Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2)	PCSK2 NEC2	Homo sapiens (Human)	638	FUNCTION: Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. {ECO:0000269|PubMed:28719828, ECO:0000269|PubMed:9287128}.		enkephalin processing [GO:0034230]; insulin processing [GO:0030070]; islet amyloid polypeptide processing [GO:0034231]; nervous system development [GO:0007399]; peptide hormone processing [GO:0016486]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]	dendrite [GO:0030425]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; secretory granule [GO:0030141]; transport vesicle [GO:0030133]	serine-type endopeptidase activity [GO:0004252]	dendrite [GO:0030425]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; secretory granule [GO:0030141]; transport vesicle [GO:0030133]; serine-type endopeptidase activity [GO:0004252]; enkephalin processing [GO:0034230]; insulin processing [GO:0030070]; islet amyloid polypeptide processing [GO:0034231]; nervous system development [GO:0007399]; peptide hormone processing [GO:0016486]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Secreted {ECO:0000269|PubMed:28719828}. Note=Localized in the secretion granules.
P16520	reviewed	GBB3_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (Transducin beta chain 3)	GNB3	Homo sapiens (Human)	340	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.		cell volume homeostasis [GO:0006884]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of blood pressure [GO:0008217]; regulation of cholesterol metabolic process [GO:0090181]; regulation of fat cell differentiation [GO:0045598]; regulation of gene expression [GO:0010468]; regulation of glucose metabolic process [GO:0010906]; regulation of hormone metabolic process [GO:0032350]; regulation of phospholipid metabolic process [GO:1903725]; regulation of triglyceride metabolic process [GO:0090207]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]	GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; signaling receptor complex adaptor activity [GO:0030159]; spectrin binding [GO:0030507]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; signaling receptor complex adaptor activity [GO:0030159]; spectrin binding [GO:0030507]; cell volume homeostasis [GO:0006884]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of blood pressure [GO:0008217]; regulation of cholesterol metabolic process [GO:0090181]; regulation of fat cell differentiation [GO:0045598]; regulation of gene expression [GO:0010468]; regulation of glucose metabolic process [GO:0010906]; regulation of hormone metabolic process [GO:0032350]; regulation of phospholipid metabolic process [GO:1903725]; regulation of triglyceride metabolic process [GO:0090207]	
P16581	reviewed	LYAM2_HUMAN	E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)	SELE ELAM1	Homo sapiens (Human)	610	FUNCTION: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. {ECO:0000269|PubMed:1689848, ECO:0000269|PubMed:28011641}.		actin filament-based process [GO:0030029]; activation of phospholipase C activity [GO:0007202]; calcium-mediated signaling [GO:0019722]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration involved in inflammatory response [GO:0002523]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of receptor internalization [GO:0002092]; regulation of inflammatory response [GO:0050727]; response to cytokine [GO:0034097]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]	caveola [GO:0005901]; clathrin-coated pit [GO:0005905]; cortical cytoskeleton [GO:0030863]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; oligosaccharide binding [GO:0070492]; phospholipase binding [GO:0043274]; sialic acid binding [GO:0033691]; transmembrane signaling receptor activity [GO:0004888]	caveola [GO:0005901]; clathrin-coated pit [GO:0005905]; cortical cytoskeleton [GO:0030863]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; oligosaccharide binding [GO:0070492]; phospholipase binding [GO:0043274]; sialic acid binding [GO:0033691]; transmembrane signaling receptor activity [GO:0004888]; actin filament-based process [GO:0030029]; activation of phospholipase C activity [GO:0007202]; calcium-mediated signaling [GO:0019722]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration involved in inflammatory response [GO:0002523]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of receptor internalization [GO:0002092]; regulation of inflammatory response [GO:0050727]; response to cytokine [GO:0034097]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12649084, ECO:0000269|PubMed:28011641}; Single-pass type I membrane protein.
P16591	reviewed	FER_HUMAN	Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer)	FER TYK3	Homo sapiens (Human)	822	FUNCTION: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. {ECO:0000269|PubMed:12972546, ECO:0000269|PubMed:14517306, ECO:0000269|PubMed:19147545, ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:19738202, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21518868, ECO:0000269|PubMed:22223638, ECO:0000269|PubMed:7623846, ECO:0000269|PubMed:9722593}.	MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; adherens junction assembly [GO:0034333]; adherens junction disassembly [GO:0120179]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to reactive oxygen species [GO:0034614]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; diapedesis [GO:0050904]; extracellular matrix-cell signaling [GO:0035426]; Fc-epsilon receptor signaling pathway [GO:0038095]; germ cell development [GO:0007281]; insulin receptor signaling pathway [GO:0008286]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; Kit signaling pathway [GO:0038109]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of mast cell activation involved in immune response [GO:0033007]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of fibroblast migration [GO:0010762]; regulation of lamellipodium assembly [GO:0010591]; regulation of mast cell degranulation [GO:0043304]; regulation of protein phosphorylation [GO:0001932]; response to lipopolysaccharide [GO:0032496]; response to platelet-derived growth factor [GO:0036119]; seminiferous tubule development [GO:0072520]; Sertoli cell development [GO:0060009]; substrate adhesion-dependent cell spreading [GO:0034446]; tyrosine phosphorylation of STAT protein [GO:0007260]	adherens junction [GO:0005912]; cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; epidermal growth factor receptor binding [GO:0005154]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase 1 binding [GO:0008157]; protein tyrosine kinase activity [GO:0004713]	adherens junction [GO:0005912]; cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; epidermal growth factor receptor binding [GO:0005154]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase 1 binding [GO:0008157]; protein tyrosine kinase activity [GO:0004713]; actin cytoskeleton organization [GO:0030036]; adherens junction assembly [GO:0034333]; adherens junction disassembly [GO:0120179]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to reactive oxygen species [GO:0034614]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; diapedesis [GO:0050904]; extracellular matrix-cell signaling [GO:0035426]; Fc-epsilon receptor signaling pathway [GO:0038095]; germ cell development [GO:0007281]; insulin receptor signaling pathway [GO:0008286]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; Kit signaling pathway [GO:0038109]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of mast cell activation involved in immune response [GO:0033007]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of fibroblast migration [GO:0010762]; regulation of lamellipodium assembly [GO:0010591]; regulation of mast cell degranulation [GO:0043304]; regulation of protein phosphorylation [GO:0001932]; response to lipopolysaccharide [GO:0032496]; response to platelet-derived growth factor [GO:0036119]; seminiferous tubule development [GO:0072520]; Sertoli cell development [GO:0060009]; substrate adhesion-dependent cell spreading [GO:0034446]; tyrosine phosphorylation of STAT protein [GO:0007260]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.
P16615	reviewed	AT2A2_HUMAN	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)	ATP2A2 ATP2B	Homo sapiens (Human)	1042	FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:16402920, PubMed:12542527). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.	MISCELLANEOUS: [Isoform 1]: Ubiquitous housekeeping isoform.; MISCELLANEOUS: [Isoform 2]: Cardiac/slow twitch, muscle specific isoform. Has a lower affinity for calcium and a higher catalytic turnover rate. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to intron retention. Shows a lower apparent affinity for cytosolic calcium than isoform 2 and a catalytic turnover rate similar to isoform 1. {ECO:0000305}.	autophagosome assembly [GO:0000045]; autophagosome membrane docking [GO:0016240]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport from cytosol to endoplasmic reticulum [GO:1903515]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cell adhesion [GO:0007155]; cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epidermis development [GO:0008544]; ER-nucleus signaling pathway [GO:0006984]; intracellular calcium ion homeostasis [GO:0006874]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of heart contraction [GO:0045822]; negative regulation of receptor binding [GO:1900121]; neuron cellular homeostasis [GO:0070050]; organelle localization by membrane tethering [GO:0140056]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; positive regulation of heart rate [GO:0010460]; regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903233]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of the force of heart contraction [GO:0002026]; relaxation of cardiac muscle [GO:0055119]; response to endoplasmic reticulum stress [GO:0034976]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; transition between fast and slow fiber [GO:0014883]	calcium ion-transporting ATPase complex [GO:0090534]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; longitudinal sarcoplasmic reticulum [GO:0014801]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; ribbon synapse [GO:0097470]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; P-type calcium transporter activity [GO:0005388]; P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential [GO:0086039]; S100 protein binding [GO:0044548]; transmembrane transporter binding [GO:0044325]	calcium ion-transporting ATPase complex [GO:0090534]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; longitudinal sarcoplasmic reticulum [GO:0014801]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; ribbon synapse [GO:0097470]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; P-type calcium transporter activity [GO:0005388]; P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential [GO:0086039]; S100 protein binding [GO:0044548]; transmembrane transporter binding [GO:0044325]; autophagosome assembly [GO:0000045]; autophagosome membrane docking [GO:0016240]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport from cytosol to endoplasmic reticulum [GO:1903515]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cell adhesion [GO:0007155]; cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epidermis development [GO:0008544]; ER-nucleus signaling pathway [GO:0006984]; intracellular calcium ion homeostasis [GO:0006874]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of heart contraction [GO:0045822]; negative regulation of receptor binding [GO:1900121]; neuron cellular homeostasis [GO:0070050]; organelle localization by membrane tethering [GO:0140056]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; positive regulation of heart rate [GO:0010460]; regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903233]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of the force of heart contraction [GO:0002026]; relaxation of cardiac muscle [GO:0055119]; response to endoplasmic reticulum stress [GO:0034976]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; transition between fast and slow fiber [GO:0014883]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O55143}; Multi-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:12804600}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with FLVCR2 at the mitochondrial-ER contact junction. {ECO:0000250|UniProtKB:O55143}.
P16619	reviewed	CL3L1_HUMAN	C-C motif chemokine 3-like 1 (G0/G1 switch regulatory protein 19-2) (LD78-beta(1-70)) (PAT 464.2) (Small-inducible cytokine A3-like 1) (Tonsillar lymphocyte LD78 beta protein) [Cleaved into: LD78-beta(3-70); LD78-beta(5-70)]	CCL3L1 D17S1718 G0S19-2 SCYA3L1; CCL3L3	Homo sapiens (Human)	93	FUNCTION: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. {ECO:0000269|PubMed:10961862, ECO:0000269|PubMed:11449371}.		cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; negative regulation of cell population proliferation [GO:0008285]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; negative regulation of cell population proliferation [GO:0008285]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	SUBCELLULAR LOCATION: Secreted.
P16662	reviewed	UD2B7_HUMAN	UDP-glucuronosyltransferase 2B7 (UDPGT 2B7) (UGT2B7) (EC 2.4.1.17) (3,4-catechol estrogen-specific UDPGT) (UDP-glucuronosyltransferase 2B9) (UDPGT 2B9) (UDPGTh-2)	UGT2B7 UGTB2B9	Homo sapiens (Human)	529	FUNCTION: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10702251, PubMed:15472229, PubMed:15470161, PubMed:18674515, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:23756265, PubMed:26220143, PubMed:17442341). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15470161, PubMed:18674515, PubMed:23756265). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:2159463, PubMed:15472229, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:26220143, PubMed:17442341). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development (PubMed:10702251). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161). {ECO:0000269|PubMed:10702251, ECO:0000269|PubMed:15470161, ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:17442341, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19022937, ECO:0000269|PubMed:2159463, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:23756265, ECO:0000269|PubMed:26220143}.		androgen metabolic process [GO:0008209]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	glucuronosyltransferase activity [GO:0015020]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; glucuronosyltransferase activity [GO:0015020]; androgen metabolic process [GO:0008209]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10702251}; Single-pass membrane protein {ECO:0000255}.
P16671	reviewed	CD36_HUMAN	Platelet glycoprotein 4 (Fatty acid translocase) (FAT) (Glycoprotein IIIb) (GPIIIB) (Leukocyte differentiation antigen CD36) (PAS IV) (PAS-4) (Platelet collagen receptor) (Platelet glycoprotein IV) (GPIV) (Thrombospondin receptor) (CD antigen CD36)	CD36 GP3B GP4	Homo sapiens (Human)	472	FUNCTION: Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). Mechanistically, binding of fatty acids activates downstream kinase LYN, which phosphorylates the palmitoyltransferase ZDHHC5 and inactivates it, resulting in the subsequent depalmitoylation of CD36 and caveolar endocytosis (PubMed:32958780). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thrombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting together with THBS1 (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211). {ECO:0000250|UniProtKB:Q07969, ECO:0000250|UniProtKB:Q08857, ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:18353783, ECO:0000269|PubMed:18753675, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:21395585, ECO:0000269|PubMed:21610069, ECO:0000269|PubMed:22240721, ECO:0000269|PubMed:25822988, ECO:0000305|PubMed:19471024}.; FUNCTION: (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling. {ECO:0000269|PubMed:10890433, ECO:0000269|PubMed:12506336, ECO:0000269|PubMed:19864601}.		amyloid fibril formation [GO:1990000]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; apoptotic cell clearance [GO:0043277]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to hydroperoxide [GO:0071447]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cGMP-mediated signaling [GO:0019934]; cholesterol import [GO:0070508]; cholesterol transport [GO:0030301]; defense response to Gram-positive bacterium [GO:0050830]; energy homeostasis [GO:0097009]; fatty acid metabolic process [GO:0006631]; intestinal absorption [GO:0050892]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; lipid transport across blood-brain barrier [GO:1990379]; lipoprotein transport [GO:0042953]; long-chain fatty acid import across plasma membrane [GO:0015911]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid transport [GO:0015909]; low-density lipoprotein particle clearance [GO:0034383]; low-density lipoprotein particle mediated signaling [GO:0055096]; MAPK cascade [GO:0000165]; negative regulation of gene expression [GO:0010629]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nitric oxide mediated signal transduction [GO:0007263]; oxidised low-density lipoprotein particle clearance [GO:0150024]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood microparticle formation [GO:2000334]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of tumor necrosis factor production [GO:0032760]; production of molecular mediator involved in inflammatory response [GO:0002532]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of action potential [GO:0098900]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of protein-containing complex assembly [GO:0043254]; regulation of removal of superoxide radicals [GO:2000121]; regulation of toll-like receptor signaling pathway [GO:0034121]; response to fatty acid [GO:0070542]; response to linoleic acid [GO:0070543]; response to lipid [GO:0033993]; response to stilbenoid [GO:0035634]; sensory perception of taste [GO:0050909]; short-chain fatty acid transport [GO:0015912]; triglyceride transport [GO:0034197]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; caveola [GO:0005901]; cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]	amyloid-beta binding [GO:0001540]; fatty acid binding [GO:0005504]; high-density lipoprotein particle binding [GO:0008035]; lipid binding [GO:0008289]; lipoprotein particle binding [GO:0071813]; lipoteichoic acid immune receptor activity [GO:0070892]; long-chain fatty acid transporter activity [GO:0005324]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; oleate transmembrane transporter activity [GO:1901480]; oxidised low-density lipoprotein particle receptor activity [GO:0150025]; protein-containing complex binding [GO:0044877]; scavenger receptor activity [GO:0005044]; short-chain fatty acid transmembrane transporter activity [GO:0015636]; thrombospondin receptor activity [GO:0070053]; Toll-like receptor binding [GO:0035325]; transforming growth factor beta binding [GO:0050431]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; caveola [GO:0005901]; cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; amyloid-beta binding [GO:0001540]; fatty acid binding [GO:0005504]; high-density lipoprotein particle binding [GO:0008035]; lipid binding [GO:0008289]; lipoprotein particle binding [GO:0071813]; lipoteichoic acid immune receptor activity [GO:0070892]; long-chain fatty acid transporter activity [GO:0005324]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; oleate transmembrane transporter activity [GO:1901480]; oxidised low-density lipoprotein particle receptor activity [GO:0150025]; protein-containing complex binding [GO:0044877]; scavenger receptor activity [GO:0005044]; short-chain fatty acid transmembrane transporter activity [GO:0015636]; thrombospondin receptor activity [GO:0070053]; Toll-like receptor binding [GO:0035325]; transforming growth factor beta binding [GO:0050431]; amyloid fibril formation [GO:1990000]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; apoptotic cell clearance [GO:0043277]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to hydroperoxide [GO:0071447]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cGMP-mediated signaling [GO:0019934]; cholesterol import [GO:0070508]; cholesterol transport [GO:0030301]; defense response to Gram-positive bacterium [GO:0050830]; energy homeostasis [GO:0097009]; fatty acid metabolic process [GO:0006631]; intestinal absorption [GO:0050892]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; lipid transport across blood-brain barrier [GO:1990379]; lipoprotein transport [GO:0042953]; long-chain fatty acid import across plasma membrane [GO:0015911]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid transport [GO:0015909]; low-density lipoprotein particle clearance [GO:0034383]; low-density lipoprotein particle mediated signaling [GO:0055096]; MAPK cascade [GO:0000165]; negative regulation of gene expression [GO:0010629]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nitric oxide mediated signal transduction [GO:0007263]; oxidised low-density lipoprotein particle clearance [GO:0150024]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood microparticle formation [GO:2000334]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of tumor necrosis factor production [GO:0032760]; production of molecular mediator involved in inflammatory response [GO:0002532]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of action potential [GO:0098900]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of protein-containing complex assembly [GO:0043254]; regulation of removal of superoxide radicals [GO:2000121]; regulation of toll-like receptor signaling pathway [GO:0034121]; response to fatty acid [GO:0070542]; response to linoleic acid [GO:0070543]; response to lipid [GO:0033993]; response to stilbenoid [GO:0035634]; sensory perception of taste [GO:0050909]; short-chain fatty acid transport [GO:0015912]; triglyceride transport [GO:0034197]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:32958780}; Multi-pass membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus {ECO:0000269|PubMed:16880211}. Apical cell membrane {ECO:0000250|UniProtKB:Q08857}. Note=Upon ligand-binding, internalized through dynamin-dependent endocytosis. {ECO:0000269|PubMed:20037584}.
P16860	reviewed	ANFB_HUMAN	Natriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into: NT-proBNP (NT-pro-BNP) (NT-proBNP(1-76)); proBNP(3-108); Brain natriuretic peptide 32 (BNP(1-32)) (BNP-32) (Brain natriuretic peptide) (BNP); BNP(1-30); BNP(1-29); BNP(1-28); BNP(2-31); BNP(3-32) (des-SerPro-BNP) (proBNP(79-108)); BNP(3-30); BNP(3-29); Brain natriuretic peptide 29 (BNP(4-32)); BNP(4-31); BNP(4-30); BNP(4-29); BNP(4-27); BNP(5-32); BNP(5-31); BNP(5-29)]	NPPB	Homo sapiens (Human)	134	FUNCTION: [Brain natriuretic peptide 32]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:9458824, PubMed:1672777, PubMed:1914098, PubMed:17372040). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:9458824, PubMed:1672777, PubMed:17372040, PubMed:21098034, PubMed:17349887, PubMed:25339504). Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed:9458824, PubMed:1914098). Binds the clearance receptor NPR3 (PubMed:16870210). {ECO:0000250|UniProtKB:P40753, ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:16870210, ECO:0000269|PubMed:17349887, ECO:0000269|PubMed:17372040, ECO:0000269|PubMed:1914098, ECO:0000269|PubMed:21098034, ECO:0000269|PubMed:25339504, ECO:0000269|PubMed:9458824}.; FUNCTION: [NT-proBNP]: May affect cardio-renal homeostasis (PubMed:17372040). Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32 (PubMed:17372040). {ECO:0000269|PubMed:17372040}.; FUNCTION: [BNP(3-32)]: May have a role in cardio-renal homeostasis (PubMed:17372040). Able to promote the production of cGMP (PubMed:17372040). {ECO:0000269|PubMed:17372040}.	MISCELLANEOUS: Plasma levels of natriuretic peptides B, brain natriuretic peptide 32 and NT-proBNP are widely used for screening and diagnosis of heart failure (HF), as these markers are typically higher in patients with severe HF. {ECO:0000269|PubMed:17349887, ECO:0000269|PubMed:17372040, ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:21482747, ECO:0000269|PubMed:25339504}.	blood vessel diameter maintenance [GO:0097746]; body fluid secretion [GO:0007589]; cardiac conduction system development [GO:0003161]; cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of urine volume [GO:0035810]; protein folding [GO:0006457]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]; vasodilation [GO:0042311]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]	diuretic hormone activity [GO:0008613]; hormone activity [GO:0005179]; hormone receptor binding [GO:0051427]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]; diuretic hormone activity [GO:0008613]; hormone activity [GO:0005179]; hormone receptor binding [GO:0051427]; signaling receptor binding [GO:0005102]; blood vessel diameter maintenance [GO:0097746]; body fluid secretion [GO:0007589]; cardiac conduction system development [GO:0003161]; cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of urine volume [GO:0035810]; protein folding [GO:0006457]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: [NT-proBNP]: Secreted {ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:25339504}. Note=Detected in blood. {ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:25339504}.; SUBCELLULAR LOCATION: [proBNP(3-108)]: Secreted {ECO:0000269|PubMed:17367664}. Note=Detected in blood. {ECO:0000269|PubMed:17367664}.; SUBCELLULAR LOCATION: [Brain natriuretic peptide 32]: Secreted {ECO:0000269|PubMed:17367664, ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:1914098, ECO:0000269|PubMed:25339504}. Note=Detected in blood. {ECO:0000269|PubMed:17367664, ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:1914098, ECO:0000269|PubMed:25339504}.; SUBCELLULAR LOCATION: [BNP(3-32)]: Secreted {ECO:0000269|PubMed:17367664}. Note=Detected in blood. {ECO:0000269|PubMed:17367664}.
P16870	reviewed	CBPE_HUMAN	Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase)	CPE	Homo sapiens (Human)	476	FUNCTION: Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. {ECO:0000250|UniProtKB:Q00493}.		cardiac left ventricle morphogenesis [GO:0003214]; insulin processing [GO:0030070]; neuropeptide signaling pathway [GO:0007218]; peptide hormone secretion [GO:0030072]; peptide metabolic process [GO:0006518]; protein localization to membrane [GO:0072657]; protein localization to secretory granule [GO:0033366]; protein modification process [GO:0036211]; protein processing [GO:0016485]; Wnt signaling pathway [GO:0016055]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]	carboxypeptidase activity [GO:0004180]; cell adhesion molecule binding [GO:0050839]; metallocarboxypeptidase activity [GO:0004181]; neurexin family protein binding [GO:0042043]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]; carboxypeptidase activity [GO:0004180]; cell adhesion molecule binding [GO:0050839]; metallocarboxypeptidase activity [GO:0004181]; neurexin family protein binding [GO:0042043]; zinc ion binding [GO:0008270]; cardiac left ventricle morphogenesis [GO:0003214]; insulin processing [GO:0030070]; neuropeptide signaling pathway [GO:0007218]; peptide hormone secretion [GO:0030072]; peptide metabolic process [GO:0006518]; protein localization to membrane [GO:0072657]; protein localization to secretory granule [GO:0033366]; protein modification process [GO:0036211]; protein processing [GO:0016485]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q00493}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P15087}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15087}. Secreted {ECO:0000250|UniProtKB:P15087}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250|UniProtKB:Q00493}.
P16871	reviewed	IL7RA_HUMAN	Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)	IL7R	Homo sapiens (Human)	459	FUNCTION: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).		B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; gene expression [GO:0010467]; hemopoiesis [GO:0030097]; immune response [GO:0006955]; lymph node development [GO:0048535]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of T cell differentiation in thymus [GO:0033089]; regulation of cell size [GO:0008361]; regulation of DNA recombination [GO:0000018]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; T cell mediated cytotoxicity [GO:0001913]	clathrin-coated endocytic vesicle membrane [GO:0030669]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]; cytokine receptor activity [GO:0004896]; interleukin-7 receptor activity [GO:0004917]	clathrin-coated endocytic vesicle membrane [GO:0030669]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; cytokine receptor activity [GO:0004896]; interleukin-7 receptor activity [GO:0004917]; B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; gene expression [GO:0010467]; hemopoiesis [GO:0030097]; immune response [GO:0006955]; lymph node development [GO:0048535]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of T cell differentiation in thymus [GO:0033089]; regulation of cell size [GO:0008361]; regulation of DNA recombination [GO:0000018]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; T cell mediated cytotoxicity [GO:0001913]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.
P16885	reviewed	PLCG2_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)	PLCG2	Homo sapiens (Human)	1265	FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:0000269|PubMed:23000145}.		antifungal innate immune response [GO:0061760]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; calcium-mediated signaling [GO:0019722]; cell activation [GO:0001775]; cellular response to calcium ion [GO:0071277]; cellular response to lectin [GO:1990858]; cellular response to lipid [GO:0071396]; Fc-epsilon receptor signaling pathway [GO:0038095]; follicular B cell differentiation [GO:0002316]; inositol trisphosphate biosynthetic process [GO:0032959]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; negative regulation of programmed cell death [GO:0043069]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid catabolic process [GO:0009395]; platelet activation [GO:0030168]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of receptor internalization [GO:0002092]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; programmed cell death [GO:0012501]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of lipid metabolic process [GO:0019216]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; response to yeast [GO:0001878]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor signaling pathway [GO:0002224]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; phosphorylation-dependent protein binding [GO:0140031]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; scaffold protein binding [GO:0097110]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; phosphorylation-dependent protein binding [GO:0140031]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; scaffold protein binding [GO:0097110]; antifungal innate immune response [GO:0061760]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; calcium-mediated signaling [GO:0019722]; cell activation [GO:0001775]; cellular response to calcium ion [GO:0071277]; cellular response to lectin [GO:1990858]; cellular response to lipid [GO:0071396]; Fc-epsilon receptor signaling pathway [GO:0038095]; follicular B cell differentiation [GO:0002316]; inositol trisphosphate biosynthetic process [GO:0032959]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; negative regulation of programmed cell death [GO:0043069]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid catabolic process [GO:0009395]; platelet activation [GO:0030168]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of receptor internalization [GO:0002092]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; programmed cell death [GO:0012501]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of lipid metabolic process [GO:0019216]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; response to yeast [GO:0001878]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor signaling pathway [GO:0002224]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Membrane raft {ECO:0000250|UniProtKB:Q8CIH5}.
P16930	reviewed	FAAA_HUMAN	Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) (Fumarylacetoacetate hydrolase)	FAH	Homo sapiens (Human)	419			arginine catabolic process [GO:0006527]; homogentisate catabolic process [GO:1902000]; L-phenylalanine catabolic process [GO:0006559]; lipid metabolic process [GO:0006629]; tyrosine catabolic process [GO:0006572]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	fumarylacetoacetase activity [GO:0004334]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fumarylacetoacetase activity [GO:0004334]; metal ion binding [GO:0046872]; arginine catabolic process [GO:0006527]; homogentisate catabolic process [GO:1902000]; L-phenylalanine catabolic process [GO:0006559]; lipid metabolic process [GO:0006629]; tyrosine catabolic process [GO:0006572]	
P16949	reviewed	STMN1_HUMAN	Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17)	STMN1 C1orf215 LAP18 OP18	Homo sapiens (Human)	149	FUNCTION: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}.		axonogenesis [GO:0007409]; establishment of skin barrier [GO:0061436]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; intracellular signal transduction [GO:0035556]; microtubule depolymerization [GO:0007019]; mitotic cytokinesis [GO:0000281]; mitotic spindle organization [GO:0007052]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; neuron projection development [GO:0031175]; regulation of cell migration [GO:0030334]; regulation of microtubule polymerization or depolymerization [GO:0031110]; response to virus [GO:0009615]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microtubule [GO:0005874]; neuron projection [GO:0043005]	tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microtubule [GO:0005874]; neuron projection [GO:0043005]; tubulin binding [GO:0015631]; axonogenesis [GO:0007409]; establishment of skin barrier [GO:0061436]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; intracellular signal transduction [GO:0035556]; microtubule depolymerization [GO:0007019]; mitotic cytokinesis [GO:0000281]; mitotic spindle organization [GO:0007052]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; neuron projection development [GO:0031175]; regulation of cell migration [GO:0030334]; regulation of microtubule polymerization or depolymerization [GO:0031110]; response to virus [GO:0009615]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P16989	reviewed	YBOX3_HUMAN	Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB)	YBX3 CSDA DBPA	Homo sapiens (Human)	372	FUNCTION: Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}.		3'-UTR-mediated mRNA stabilization [GO:0070935]; apoptotic process [GO:0006915]; cellular hyperosmotic response [GO:0071474]; cellular response to tumor necrosis factor [GO:0071356]; ectopic germ cell programmed cell death [GO:0035234]; fertilization [GO:0009566]; in utero embryonic development [GO:0001701]; male gonad development [GO:0008584]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of necroptotic process [GO:0060546]; negative regulation of reproductive process [GO:2000242]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of organ growth [GO:0046622]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283]	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]	mRNA 3'-UTR binding [GO:0003730]; nucleic acid binding [GO:0003676]; polysome binding [GO:1905538]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; small GTPase binding [GO:0031267]	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]; mRNA 3'-UTR binding [GO:0003730]; nucleic acid binding [GO:0003676]; polysome binding [GO:1905538]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; small GTPase binding [GO:0031267]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; apoptotic process [GO:0006915]; cellular hyperosmotic response [GO:0071474]; cellular response to tumor necrosis factor [GO:0071356]; ectopic germ cell programmed cell death [GO:0035234]; fertilization [GO:0009566]; in utero embryonic development [GO:0001701]; male gonad development [GO:0008584]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of necroptotic process [GO:0060546]; negative regulation of reproductive process [GO:2000242]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of organ growth [GO:0046622]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
P17010	reviewed	ZFX_HUMAN	Zinc finger X-chromosomal protein	ZFX	Homo sapiens (Human)	805	FUNCTION: Probable transcriptional activator.		fertilization [GO:0009566]; homeostasis of number of cells [GO:0048872]; multicellular organism growth [GO:0035264]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; parental behavior [GO:0060746]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	chromatin insulator sequence binding [GO:0043035]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; chromatin insulator sequence binding [GO:0043035]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; fertilization [GO:0009566]; homeostasis of number of cells [GO:0048872]; multicellular organism growth [GO:0035264]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; parental behavior [GO:0060746]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus.
P17014	reviewed	ZNF12_HUMAN	Zinc finger protein 12 (Gonadotropin-inducible ovary transcription repressor 3) (GIOT-3) (Zinc finger protein 325) (Zinc finger protein KOX3)	ZNF12 GIOT3 KOX3 ZNF325	Homo sapiens (Human)	697	FUNCTION: Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity. {ECO:0000269|PubMed:16806083}.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	centrosome [GO:0005813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	centrosome [GO:0005813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16806083}.
P17020	reviewed	ZNF16_HUMAN	Zinc finger protein 16 (Zinc finger protein KOX9)	ZNF16 HZF1 KOX9	Homo sapiens (Human)	682	FUNCTION: Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Also plays a role as an inhibitor of cell apoptosis. {ECO:0000269|PubMed:16628192, ECO:0000269|PubMed:19763908, ECO:0000269|PubMed:21874239}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to sodium dodecyl sulfate [GO:0072707]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell cycle phase transition [GO:1901989]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of kinase activity [GO:0033674]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to sodium dodecyl sulfate [GO:0072707]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell cycle phase transition [GO:1901989]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of kinase activity [GO:0033674]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16628192}.
P17021	reviewed	ZNF17_HUMAN	Zinc finger protein 17 (Zinc finger protein HPF3) (Zinc finger protein KOX10)	ZNF17 KIAA1947 KOX10	Homo sapiens (Human)	662	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17022	reviewed	ZNF18_HUMAN	Zinc finger protein 18 (Heart development-specific gene 1 protein) (Zinc finger protein 535) (Zinc finger protein KOX11) (Zinc finger protein with KRAB and SCAN domains 6)	ZNF18 HDSG1 KOX11 ZKSCAN6 ZNF535	Homo sapiens (Human)	549	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
P17023	reviewed	ZNF19_HUMAN	Zinc finger protein 19 (Zinc finger protein KOX12)	ZNF19 KOX12	Homo sapiens (Human)	458	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17024	reviewed	ZNF20_HUMAN	Zinc finger protein 20 (Zinc finger protein KOX13)	ZNF20 KOX13	Homo sapiens (Human)	532	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17027	reviewed	ZNF23_HUMAN	Zinc finger protein 23 (Zinc finger protein 359) (Zinc finger protein 612) (Zinc finger protein KOX16)	ZNF23 KOX16 ZNF359 ZNF612	Homo sapiens (Human)	643	FUNCTION: May be involved in transcriptional regulation. May have a role in embryonic development.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17028	reviewed	ZNF24_HUMAN	Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17)	ZNF24 KOX17 ZNF191 ZSCAN3	Homo sapiens (Human)	368	FUNCTION: Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}.		myelination [GO:0042552]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; myelination [GO:0042552]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187, ECO:0000269|PubMed:24224020}.
P17036	reviewed	ZNF3_HUMAN	Zinc finger protein 3 (Zinc finger protein HF.12) (Zinc finger protein HZF3.1) (Zinc finger protein KOX25)	ZNF3 KOX25	Homo sapiens (Human)	446	FUNCTION: Involved in cell differentiation and/or proliferation.		cell differentiation [GO:0030154]; leukocyte activation [GO:0045321]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; leukocyte activation [GO:0045321]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17040	reviewed	ZSC20_HUMAN	Zinc finger and SCAN domain-containing protein 20 (Zinc finger protein 31) (Zinc finger protein 360) (Zinc finger protein KOX29)	ZSCAN20 KOX29 ZNF31 ZNF360	Homo sapiens (Human)	1043	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
P17041	reviewed	ZNF32_HUMAN	Zinc finger protein 32 (C2H2-546) (Zinc finger protein KOX30)	ZNF32 KOX30	Homo sapiens (Human)	273	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17050	reviewed	NAGAB_HUMAN	Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B)	NAGA	Homo sapiens (Human)	411	FUNCTION: Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids. {ECO:0000269|PubMed:9741689}.	MISCELLANEOUS: Alpha-galactosidase B was first found to be an isoenzyme of alpha-galactosidases, but apparently it differs from alpha-galactosidase A in substrate specificity and is alpha-N-acetylgalactosaminidase.	carbohydrate catabolic process [GO:0016052]; glycolipid catabolic process [GO:0019377]; glycoside catabolic process [GO:0016139]; oligosaccharide metabolic process [GO:0009311]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]	alpha-galactosidase activity [GO:0004557]; alpha-N-acetylgalactosaminidase activity [GO:0008456]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; alpha-galactosidase activity [GO:0004557]; alpha-N-acetylgalactosaminidase activity [GO:0008456]; protein homodimerization activity [GO:0042803]; carbohydrate catabolic process [GO:0016052]; glycolipid catabolic process [GO:0019377]; glycoside catabolic process [GO:0016139]; oligosaccharide metabolic process [GO:0009311]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:9741689}.
P17066	reviewed	HSP76_HUMAN	Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B')	HSPA6 HSP70B'	Homo sapiens (Human)	643	FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}.		cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026]; response to unfolded protein [GO:0006986]	blood microparticle [GO:0072562]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	blood microparticle [GO:0072562]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026]; response to unfolded protein [GO:0006986]	
P17081	reviewed	RHOQ_HUMAN	Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)	RHOQ ARHQ RASL7A TC10	Homo sapiens (Human)	205	FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. {ECO:0000269|PubMed:15546864}.		actin filament organization [GO:0007015]; cellular response to insulin stimulus [GO:0032869]; cortical actin cytoskeleton organization [GO:0030866]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]; GTP metabolic process [GO:0046039]; insulin receptor signaling pathway [GO:0008286]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of glucose import [GO:0046326]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	actin filament [GO:0005884]; extracellular exosome [GO:0070062]; Golgi-associated vesicle membrane [GO:0030660]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GBD domain binding [GO:0032427]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; profilin binding [GO:0005522]; protein kinase binding [GO:0019901]	actin filament [GO:0005884]; extracellular exosome [GO:0070062]; Golgi-associated vesicle membrane [GO:0030660]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; GBD domain binding [GO:0032427]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; profilin binding [GO:0005522]; protein kinase binding [GO:0019901]; actin filament organization [GO:0007015]; cellular response to insulin stimulus [GO:0032869]; cortical actin cytoskeleton organization [GO:0030866]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]; GTP metabolic process [GO:0046039]; insulin receptor signaling pathway [GO:0008286]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of glucose import [GO:0046326]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15546864}. Cell membrane {ECO:0000269|PubMed:15546864}; Lipid-anchor {ECO:0000269|PubMed:15546864}.
P17096	reviewed	HMGA1_HUMAN	High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R)	HMGA1 HMGIY	Homo sapiens (Human)	107	FUNCTION: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.		base-excision repair [GO:0006284]; DNA unwinding involved in DNA replication [GO:0006268]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome disassembly [GO:0006337]; oncogene-induced cell senescence [GO:0090402]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; senescence-associated heterochromatin focus [GO:0035985]; transcription regulator complex [GO:0005667]	5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; enzyme binding [GO:0019899]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; peroxisome proliferator activated receptor binding [GO:0042975]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; structural constituent of chromatin [GO:0030527]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription coregulator binding [GO:0001221]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; senescence-associated heterochromatin focus [GO:0035985]; transcription regulator complex [GO:0005667]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; enzyme binding [GO:0019899]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; peroxisome proliferator activated receptor binding [GO:0042975]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; structural constituent of chromatin [GO:0030527]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription coregulator binding [GO:0001221]; base-excision repair [GO:0006284]; DNA unwinding involved in DNA replication [GO:0006268]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome disassembly [GO:0006337]; oncogene-induced cell senescence [GO:0090402]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P17152	reviewed	TMM11_HUMAN	Transmembrane protein 11, mitochondrial (Protein PM1) (Protein PMI)	TMEM11 C17orf35 PM1	Homo sapiens (Human)	192	FUNCTION: Plays a role in mitochondrial morphogenesis. {ECO:0000269|PubMed:21274005}.		inner mitochondrial membrane organization [GO:0007007]; mitochondrion organization [GO:0007005]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; inner mitochondrial membrane organization [GO:0007007]; mitochondrion organization [GO:0007005]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21274005}; Multi-pass membrane protein {ECO:0000269|PubMed:21274005}.
P17174	reviewed	AATC_HUMAN	Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)	GOT1	Homo sapiens (Human)	413	FUNCTION: Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}.	MISCELLANEOUS: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.; MISCELLANEOUS: Aspartate aminotransferase activity found to be increased in cerebral spinal fluid (CSF) of patients with Alzheimer disease (PubMed:16039064). Fetal serum levels of the enzyme in the umbilical artery and vein are found to be significantly higher than maternal serum levels (PubMed:22633534). {ECO:0000305|PubMed:16039064, ECO:0000305|PubMed:22633534}.	2-oxoglutarate metabolic process [GO:0006103]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; cellular response to insulin stimulus [GO:0032869]; fatty acid homeostasis [GO:0055089]; gluconeogenesis [GO:0006094]; glutamate catabolic process to 2-oxoglutarate [GO:0019551]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; glycerol biosynthetic process [GO:0006114]; Notch signaling pathway [GO:0007219]; oxaloacetate metabolic process [GO:0006107]; response to glucocorticoid [GO:0051384]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; L-cysteine transaminase activity [GO:0047801]; phosphatidylserine decarboxylase activity [GO:0004609]; pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; L-cysteine transaminase activity [GO:0047801]; phosphatidylserine decarboxylase activity [GO:0004609]; pyridoxal phosphate binding [GO:0030170]; 2-oxoglutarate metabolic process [GO:0006103]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; cellular response to insulin stimulus [GO:0032869]; fatty acid homeostasis [GO:0055089]; gluconeogenesis [GO:0006094]; glutamate catabolic process to 2-oxoglutarate [GO:0019551]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; glycerol biosynthetic process [GO:0006114]; Notch signaling pathway [GO:0007219]; oxaloacetate metabolic process [GO:0006107]; response to glucocorticoid [GO:0051384]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1974457}.
P17181	reviewed	INAR1_HUMAN	Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)	IFNAR1 IFNAR	Homo sapiens (Human)	557	FUNCTION: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:2153461, PubMed:7813427, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:24075985, PubMed:21854986, PubMed:31270247, PubMed:33252644, PubMed:35442418). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:7665574, PubMed:10049744, PubMed:21854986). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:7813427, PubMed:7665574, PubMed:21854986, PubMed:32972995). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (PubMed:7813427, PubMed:7526154, PubMed:7665574, PubMed:21854986, PubMed:32972995). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:7813427, PubMed:7665574, PubMed:9121453, PubMed:19561067, PubMed:21854986, PubMed:32972995). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). {ECO:0000250|UniProtKB:P33896, ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:15337770, ECO:0000269|PubMed:19561067, ECO:0000269|PubMed:2153461, ECO:0000269|PubMed:21854986, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:31270247, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33252644, ECO:0000269|PubMed:35442418, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:9121453}.	MISCELLANEOUS: [Isoform 2]: Incomplete sequence. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Incomplete sequence. {ECO:0000305}.	cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; positive regulation of cellular respiration [GO:1901857]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to lipopolysaccharide [GO:0032496]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	cytokine binding [GO:0019955]; JAK pathway signal transduction adaptor activity [GO:0008269]; type I interferon binding [GO:0019962]; type I interferon receptor activity [GO:0004905]	late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; cytokine binding [GO:0019955]; JAK pathway signal transduction adaptor activity [GO:0008269]; type I interferon binding [GO:0019962]; type I interferon receptor activity [GO:0004905]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; positive regulation of cellular respiration [GO:1901857]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to lipopolysaccharide [GO:0032496]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:18056411, ECO:0000269|PubMed:2153461, ECO:0000269|PubMed:35442418, ECO:0000305|PubMed:7665574}; Single-pass type I membrane protein {ECO:0000305}. Late endosome {ECO:0000269|PubMed:18056411, ECO:0000305|PubMed:14532120}. Lysosome {ECO:0000269|PubMed:18056411, ECO:0000305|PubMed:14532120}. Note=Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes. {ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:18056411}.
P17213	reviewed	BPI_HUMAN	Bactericidal permeability-increasing protein (BPI) (CAP 57)	BPI	Homo sapiens (Human)	487	FUNCTION: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. {ECO:0000269|PubMed:1937776, ECO:0000269|PubMed:2722846}.		defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of macrophage activation [GO:0043031]; negative regulation of tumor necrosis factor production [GO:0032720]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; specific granule lumen [GO:0035580]	lipopolysaccharide binding [GO:0001530]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; specific granule lumen [GO:0035580]; lipopolysaccharide binding [GO:0001530]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of macrophage activation [GO:0043031]; negative regulation of tumor necrosis factor production [GO:0032720]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8812832}. Cytoplasmic granule membrane {ECO:0000269|PubMed:2722846}. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000269|PubMed:2722846}.
P17252	reviewed	KPCA_HUMAN	Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)	PRKCA PKCA PRKACA	Homo sapiens (Human)	672	FUNCTION: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}.		angiogenesis [GO:0001525]; apoptotic signaling pathway [GO:0097190]; cell adhesion [GO:0007155]; desmosome assembly [GO:0002159]; intracellular signal transduction [GO:0035556]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of glial cell apoptotic process [GO:0034351]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of angiogenesis [GO:0045766]; positive regulation of angiotensin-activated signaling pathway [GO:0110063]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of bone resorption [GO:0045780]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of dense core granule biogenesis [GO:2000707]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic cell cycle [GO:0045931]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of mRNA stability [GO:0043488]; regulation of platelet aggregation [GO:0090330]; response to interleukin-1 [GO:0070555]	alphav-beta3 integrin-PKCalpha complex [GO:0035866]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; enzyme binding [GO:0019899]; histone H3T6 kinase activity [GO:0035403]; integrin binding [GO:0005178]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]	alphav-beta3 integrin-PKCalpha complex [GO:0035866]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; enzyme binding [GO:0019899]; histone H3T6 kinase activity [GO:0035403]; integrin binding [GO:0005178]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]; angiogenesis [GO:0001525]; apoptotic signaling pathway [GO:0097190]; cell adhesion [GO:0007155]; desmosome assembly [GO:0002159]; intracellular signal transduction [GO:0035556]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of glial cell apoptotic process [GO:0034351]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of angiogenesis [GO:0045766]; positive regulation of angiotensin-activated signaling pathway [GO:0110063]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of bone resorption [GO:0045780]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of dense core granule biogenesis [GO:2000707]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic cell cycle [GO:0045931]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of mRNA stability [GO:0043488]; regulation of platelet aggregation [GO:0090330]; response to interleukin-1 [GO:0070555]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23990668}. Cell membrane {ECO:0000269|PubMed:23990668}; Peripheral membrane protein {ECO:0000305|PubMed:23990668}. Mitochondrion membrane {ECO:0000269|PubMed:9738012}; Peripheral membrane protein {ECO:0000305|PubMed:9738012}. Nucleus {ECO:0000250|UniProtKB:P20444}.
P17275	reviewed	JUNB_HUMAN	Transcription factor JunB (Transcription factor AP-1 subunit JunB)	JUNB	Homo sapiens (Human)	347	FUNCTION: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P09450}.		cellular response to calcium ion [GO:0071277]; decidualization [GO:0046697]; embryonic process involved in female pregnancy [GO:0060136]; integrated stress response signaling [GO:0140467]; labyrinthine layer blood vessel development [GO:0060716]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of T-helper 17 cell differentiation [GO:2000319]; regulation of transcription by RNA polymerase II [GO:0006357]; trophectodermal cell differentiation [GO:0001829]; vasculogenesis [GO:0001570]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to calcium ion [GO:0071277]; decidualization [GO:0046697]; embryonic process involved in female pregnancy [GO:0060136]; integrated stress response signaling [GO:0140467]; labyrinthine layer blood vessel development [GO:0060716]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of T-helper 17 cell differentiation [GO:2000319]; regulation of transcription by RNA polymerase II [GO:0006357]; trophectodermal cell differentiation [GO:0001829]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Nucleus.
P17301	reviewed	ITA2_HUMAN	Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)	ITGA2 CD49B	Homo sapiens (Human)	1181	FUNCTION: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. {ECO:0000269|PubMed:12941907}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. {ECO:0000269|PubMed:8411387}.		animal organ morphogenesis [GO:0009887]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cellular response to estradiol stimulus [GO:0071392]; cellular response to mechanical stimulus [GO:0071260]; collagen-activated signaling pathway [GO:0038065]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; female pregnancy [GO:0007565]; focal adhesion assembly [GO:0048041]; hepatocyte differentiation [GO:0070365]; hypotonic response [GO:0006971]; integrin-mediated signaling pathway [GO:0007229]; mammary gland development [GO:0030879]; mesodermal cell differentiation [GO:0048333]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell projection organization [GO:0031346]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of translation [GO:0045727]; positive regulation of transmission of nerve impulse [GO:0051971]; response to amine [GO:0014075]; response to hypoxia [GO:0001666]; response to L-ascorbic acid [GO:0033591]; response to muscle activity [GO:0014850]; response to parathyroid hormone [GO:0071107]; response to xenobiotic stimulus [GO:0009410]; skin morphogenesis [GO:0043589]; substrate-dependent cell migration [GO:0006929]	axon terminus [GO:0043679]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alpha2-beta1 complex [GO:0034666]; integrin complex [GO:0008305]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	amyloid-beta binding [GO:0001540]; collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; collagen receptor activity [GO:0038064]; heparan sulfate proteoglycan binding [GO:0043395]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; virus receptor activity [GO:0001618]	axon terminus [GO:0043679]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alpha2-beta1 complex [GO:0034666]; integrin complex [GO:0008305]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; amyloid-beta binding [GO:0001540]; collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; collagen receptor activity [GO:0038064]; heparan sulfate proteoglycan binding [GO:0043395]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; virus receptor activity [GO:0001618]; animal organ morphogenesis [GO:0009887]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cellular response to estradiol stimulus [GO:0071392]; cellular response to mechanical stimulus [GO:0071260]; collagen-activated signaling pathway [GO:0038065]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; female pregnancy [GO:0007565]; focal adhesion assembly [GO:0048041]; hepatocyte differentiation [GO:0070365]; hypotonic response [GO:0006971]; integrin-mediated signaling pathway [GO:0007229]; mammary gland development [GO:0030879]; mesodermal cell differentiation [GO:0048333]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell projection organization [GO:0031346]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of translation [GO:0045727]; positive regulation of transmission of nerve impulse [GO:0051971]; response to amine [GO:0014075]; response to hypoxia [GO:0001666]; response to L-ascorbic acid [GO:0033591]; response to muscle activity [GO:0014850]; response to parathyroid hormone [GO:0071107]; response to xenobiotic stimulus [GO:0009410]; skin morphogenesis [GO:0043589]; substrate-dependent cell migration [GO:0006929]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P17302	reviewed	CXA1_HUMAN	Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)	GJA1 GJAL	Homo sapiens (Human)	382	FUNCTION: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}.		atrial cardiac muscle cell action potential [GO:0086014]; bone development [GO:0060348]; bone remodeling [GO:0046849]; cardiac conduction system development [GO:0003161]; cell communication by electrical coupling [GO:0010644]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-cell signaling [GO:0007267]; cellular response to amyloid-beta [GO:1904646]; establishment of mitotic spindle orientation [GO:0000132]; export across plasma membrane [GO:0140115]; gap junction assembly [GO:0016264]; glutamate secretion [GO:0014047]; heart development [GO:0007507]; maintenance of blood-brain barrier [GO:0035633]; microtubule-based transport [GO:0099111]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cell growth [GO:0030308]; negative regulation of gonadotropin secretion [GO:0032277]; negative regulation of trophoblast cell migration [GO:1901164]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of gene expression [GO:0010628]; positive regulation of mesodermal cell differentiation [GO:1905772]; positive regulation of morphogenesis of an epithelium [GO:1905332]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein localization [GO:0008104]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; xenobiotic transport [GO:0042908]	apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; connexin complex [GO:0005922]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; gap junction [GO:0005921]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; tight junction [GO:0070160]	alpha-tubulin binding [GO:0043014]; beta-catenin binding [GO:0008013]; efflux transmembrane transporter activity [GO:0015562]; gap junction channel activity [GO:0005243]; gap junction channel activity involved in cardiac conduction electrical coupling [GO:0086075]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763]; gap junction hemi-channel activity [GO:0055077]; glutathione transmembrane transporter activity [GO:0034634]; monoatomic ion transmembrane transporter activity [GO:0015075]; tubulin binding [GO:0015631]	apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; connexin complex [GO:0005922]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; gap junction [GO:0005921]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; tight junction [GO:0070160]; alpha-tubulin binding [GO:0043014]; beta-catenin binding [GO:0008013]; efflux transmembrane transporter activity [GO:0015562]; gap junction channel activity [GO:0005243]; gap junction channel activity involved in cardiac conduction electrical coupling [GO:0086075]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763]; gap junction hemi-channel activity [GO:0055077]; glutathione transmembrane transporter activity [GO:0034634]; monoatomic ion transmembrane transporter activity [GO:0015075]; tubulin binding [GO:0015631]; atrial cardiac muscle cell action potential [GO:0086014]; bone development [GO:0060348]; bone remodeling [GO:0046849]; cardiac conduction system development [GO:0003161]; cell communication by electrical coupling [GO:0010644]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-cell signaling [GO:0007267]; cellular response to amyloid-beta [GO:1904646]; establishment of mitotic spindle orientation [GO:0000132]; export across plasma membrane [GO:0140115]; gap junction assembly [GO:0016264]; glutamate secretion [GO:0014047]; heart development [GO:0007507]; maintenance of blood-brain barrier [GO:0035633]; microtubule-based transport [GO:0099111]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cell growth [GO:0030308]; negative regulation of gonadotropin secretion [GO:0032277]; negative regulation of trophoblast cell migration [GO:1901164]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of gene expression [GO:0010628]; positive regulation of mesodermal cell differentiation [GO:1905772]; positive regulation of morphogenesis of an epithelium [GO:1905332]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein localization [GO:0008104]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22411987, ECO:0000269|PubMed:25398053}; Multi-pass membrane protein {ECO:0000255}. Cell junction, gap junction {ECO:0000269|PubMed:22411987, ECO:0000269|PubMed:25398053}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P23242}. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65. {ECO:0000250|UniProtKB:P23242}.
P17342	reviewed	ANPRC_HUMAN	Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C)	NPR3 ANPRC C5orf23 NPRC	Homo sapiens (Human)	541	FUNCTION: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. {ECO:0000250|UniProtKB:P70180}.	MISCELLANEOUS: Has low affinity for peptide hormones in the absence of bound chloride.	angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; negative regulation of cold-induced thermogenesis [GO:0120163]; osteoclast proliferation [GO:0002158]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of urine volume [GO:0035810]; regulation of blood pressure [GO:0008217]; regulation of osteoblast proliferation [GO:0033688]; response to ischemia [GO:0002931]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	chloride ion binding [GO:0031404]; G protein-coupled peptide receptor activity [GO:0008528]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; chloride ion binding [GO:0031404]; G protein-coupled peptide receptor activity [GO:0008528]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; negative regulation of cold-induced thermogenesis [GO:0120163]; osteoclast proliferation [GO:0002158]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of urine volume [GO:0035810]; regulation of blood pressure [GO:0008217]; regulation of osteoblast proliferation [GO:0033688]; response to ischemia [GO:0002931]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30032985}; Single-pass type I membrane protein.
P17405	reviewed	ASM_HUMAN	Sphingomyelin phosphodiesterase (EC 3.1.4.12) (EC 3.1.4.3) (Acid sphingomyelinase) (aSMase) [Cleaved into: Sphingomyelin phosphodiesterase, processed form]	SMPD1 ASM	Homo sapiens (Human)	631	FUNCTION: Converts sphingomyelin to ceramide (PubMed:1840600, PubMed:18815062, PubMed:27659707, PubMed:25920558, PubMed:25339683, PubMed:33163980, PubMed:12563314). Exists as two enzymatic forms that arise from alternative trafficking of a single protein precursor, one that is targeted to the endolysosomal compartment, whereas the other is released extracellularly (PubMed:21098024, PubMed:9660788, PubMed:20807762). However, in response to various forms of stress, lysosomal exocytosis may represent a major source of the secretory form (PubMed:20530211, PubMed:12563314, PubMed:20807762, PubMed:9393854, PubMed:22573858). {ECO:0000269|PubMed:12563314, ECO:0000269|PubMed:1840600, ECO:0000269|PubMed:18815062, ECO:0000269|PubMed:20530211, ECO:0000269|PubMed:20807762, ECO:0000269|PubMed:21098024, ECO:0000269|PubMed:22573858, ECO:0000269|PubMed:25339683, ECO:0000269|PubMed:25920558, ECO:0000269|PubMed:27659707, ECO:0000269|PubMed:33163980, ECO:0000269|PubMed:9393854, ECO:0000269|PubMed:9660788, ECO:0000305}.; FUNCTION: In the lysosomes, converts sphingomyelin to ceramide (PubMed:20807762, PubMed:21098024). Plays an important role in the export of cholesterol from the intraendolysosomal membranes (PubMed:25339683). Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol (PubMed:25339683). Modulates stress-induced apoptosis through the production of ceramide (PubMed:8706124). {ECO:0000269|PubMed:20807762, ECO:0000269|PubMed:21098024, ECO:0000269|PubMed:25339683, ECO:0000269|PubMed:8706124}.; FUNCTION: When secreted, modulates cell signaling with its ability to reorganize the plasma membrane by converting sphingomyelin to ceramide (PubMed:12563314, PubMed:20807762, PubMed:17303575). Secreted form is increased in response to stress and inflammatory mediators such as IL1B, IFNG or TNF as well as upon infection with bacteria and viruses (PubMed:12563314, PubMed:20807762, PubMed:9393854). Produces the release of ceramide in the outer leaflet of the plasma membrane playing a central role in host defense (PubMed:12563314, PubMed:20807762, PubMed:9393854). Ceramide reorganizes these rafts into larger signaling platforms that are required to internalize P. aeruginosa, induce apoptosis and regulate the cytokine response in infected cells (PubMed:12563314). In wounded cells, the lysosomal form is released extracellularly in the presence of Ca(2+) and promotes endocytosis and plasma membrane repair (PubMed:20530211). {ECO:0000269|PubMed:12563314, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:20530211, ECO:0000269|PubMed:20807762, ECO:0000269|PubMed:9393854}.; FUNCTION: [Sphingomyelin phosphodiesterase, processed form]: This form is generated following cleavage by CASP7 in the extracellular milieu in response to bacterial infection (PubMed:21157428). It shows increased ability to convert sphingomyelin to ceramide and promotes plasma membrane repair (By similarity). Plasma membrane repair by ceramide counteracts the action of gasdermin-D (GSDMD) perforin (PRF1) pores that are formed in response to bacterial infection (By similarity). {ECO:0000250|UniProtKB:Q04519, ECO:0000269|PubMed:21157428}.; FUNCTION: (Microbial infection) Secretion is activated by bacteria such as P. aeruginos, N. gonorrhoeae and others, this activation results in the release of ceramide in the outer leaflet of the plasma membrane which facilitates the infection. {ECO:0000269|PubMed:12563314, ECO:0000269|PubMed:9393854, ECO:0000305|PubMed:31155842}.; FUNCTION: (Microbial infection) Secretion is activated by human coronaviruses SARS-CoV and SARS-CoV-2 as well as Zaire ebolavirus, this activation results in the release of ceramide in the outer leaflet of the plasma membrane which facilitates the infection. {ECO:0000269|PubMed:22573858, ECO:0000269|PubMed:33163980}.; FUNCTION: [Isoform 2]: Lacks residues that bind the cofactor Zn(2+) and has no enzyme activity. {ECO:0000269|PubMed:1840600, ECO:0000305}.; FUNCTION: [Isoform 3]: Lacks residues that bind the cofactor Zn(2+) and has no enzyme activity. {ECO:0000269|PubMed:1840600, ECO:0000305}.	MISCELLANEOUS: There are two types of sphingomyelinases: ASM (acid), and NSM (neutral).; MISCELLANEOUS: [Isoform 1]: Most abundant (90%).; MISCELLANEOUS: [Isoform 2]: Intermediate abundance (10%). {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Low abundance (<1%). {ECO:0000305}.	cellular response to calcium ion [GO:0071277]; cellular response to UV [GO:0034644]; ceramide biosynthetic process [GO:0046513]; cholesterol metabolic process [GO:0008203]; glycosphingolipid metabolic process [GO:0006687]; negative regulation of MAP kinase activity [GO:0043407]; nervous system development [GO:0007399]; plasma membrane repair [GO:0001778]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endocytosis [GO:0045807]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of viral entry into host cell [GO:0046598]; response to cocaine [GO:0042220]; response to interleukin-1 [GO:0070555]; response to ionizing radiation [GO:0010212]; response to tumor necrosis factor [GO:0034612]; response to type I interferon [GO:0034340]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684]; termination of signal transduction [GO:0023021]; viral entry into host cell [GO:0046718]; wound healing [GO:0042060]	endolysosome [GO:0036019]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; lipid droplet [GO:0005811]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	acid sphingomyelin phosphodiesterase activity [GO:0061750]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; phosphatidylcholine phospholipase C activity [GO:0034480]; sphingomyelin phosphodiesterase activity [GO:0004767]; zinc ion binding [GO:0008270]	endolysosome [GO:0036019]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; lipid droplet [GO:0005811]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; acid sphingomyelin phosphodiesterase activity [GO:0061750]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; phosphatidylcholine phospholipase C activity [GO:0034480]; sphingomyelin phosphodiesterase activity [GO:0004767]; zinc ion binding [GO:0008270]; cellular response to calcium ion [GO:0071277]; cellular response to UV [GO:0034644]; ceramide biosynthetic process [GO:0046513]; cholesterol metabolic process [GO:0008203]; glycosphingolipid metabolic process [GO:0006687]; negative regulation of MAP kinase activity [GO:0043407]; nervous system development [GO:0007399]; plasma membrane repair [GO:0001778]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endocytosis [GO:0045807]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of viral entry into host cell [GO:0046598]; response to cocaine [GO:0042220]; response to interleukin-1 [GO:0070555]; response to ionizing radiation [GO:0010212]; response to tumor necrosis factor [GO:0034612]; response to type I interferon [GO:0034340]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684]; termination of signal transduction [GO:0023021]; viral entry into host cell [GO:0046718]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:18815062, ECO:0000269|PubMed:20530211, ECO:0000269|PubMed:20807762, ECO:0000269|PubMed:27659707, ECO:0000269|PubMed:9660788}. Lipid droplet {ECO:0000269|PubMed:25339683}. Secreted {ECO:0000269|PubMed:12563314, ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:20530211, ECO:0000269|PubMed:20807762, ECO:0000269|PubMed:22573858, ECO:0000269|PubMed:27659707, ECO:0000269|PubMed:8702487, ECO:0000269|PubMed:9030779, ECO:0000269|PubMed:9660788}. Note=The secreted form is induced in a time- and dose-dependent by IL1B and TNF as well as stress and viral infection. This increase of the secreted form seems to be due to exocytosis of the lysosomal form and is Ca(2+)-dependent (PubMed:20807762, PubMed:22573858, PubMed:20530211). Secretion is dependent of phosphorylation at Ser-510 (PubMed:17303575). Secretion is induced by inflammatory mediators such as IL1B, IFNG or TNF as well as infection with bacteria and viruses (PubMed:12563314, PubMed:20807762). {ECO:0000269|PubMed:12563314, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:20530211, ECO:0000269|PubMed:20807762, ECO:0000269|PubMed:22573858}.; SUBCELLULAR LOCATION: [Sphingomyelin phosphodiesterase, processed form]: Secreted, extracellular space {ECO:0000250|UniProtKB:Q04519}. Note=This form is generated following cleavage by CASP7. {ECO:0000250|UniProtKB:Q04519}.
P17480	reviewed	UBF1_HUMAN	Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1)	UBTF UBF UBF1	Homo sapiens (Human)	764	FUNCTION: Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. {ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}.		positive regulation of transcription by RNA polymerase I [GO:0045943]; transcription by RNA polymerase I [GO:0006360]; transcription initiation at RNA polymerase I promoter [GO:0006361]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; RNA binding [GO:0003723]; RNA polymerase I cis-regulatory region sequence-specific DNA binding [GO:0001165]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; scaffold protein binding [GO:0097110]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; RNA binding [GO:0003723]; RNA polymerase I cis-regulatory region sequence-specific DNA binding [GO:0001165]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; scaffold protein binding [GO:0097110]; positive regulation of transcription by RNA polymerase I [GO:0045943]; transcription by RNA polymerase I [GO:0006360]; transcription initiation at RNA polymerase I promoter [GO:0006361]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P25976}.
P17481	reviewed	HXB8_HUMAN	Homeobox protein Hox-B8 (Homeobox protein Hox-2.4) (Homeobox protein Hox-2D)	HOXB8 HOX2D	Homo sapiens (Human)	243	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		adult locomotory behavior [GO:0008344]; anterior/posterior pattern specification [GO:0009952]; dorsal spinal cord development [GO:0021516]; embryonic skeletal system morphogenesis [GO:0048704]; grooming behavior [GO:0007625]; negative regulation of myeloid cell differentiation [GO:0045638]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of pain [GO:0019233]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; adult locomotory behavior [GO:0008344]; anterior/posterior pattern specification [GO:0009952]; dorsal spinal cord development [GO:0021516]; embryonic skeletal system morphogenesis [GO:0048704]; grooming behavior [GO:0007625]; negative regulation of myeloid cell differentiation [GO:0045638]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of pain [GO:0019233]	SUBCELLULAR LOCATION: Nucleus.
P17482	reviewed	HXB9_HUMAN	Homeobox protein Hox-B9 (Homeobox protein Hox-2.5) (Homeobox protein Hox-2E)	HOXB9 HOX2E	Homo sapiens (Human)	250	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; cell chemotaxis [GO:0060326]; DNA-templated transcription [GO:0006351]; embryonic skeletal system morphogenesis [GO:0048704]; mammary gland development [GO:0030879]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; cell chemotaxis [GO:0060326]; DNA-templated transcription [GO:0006351]; embryonic skeletal system morphogenesis [GO:0048704]; mammary gland development [GO:0030879]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P17483	reviewed	HXB4_HUMAN	Homeobox protein Hox-B4 (Homeobox protein Hox-2.6) (Homeobox protein Hox-2F)	HOXB4 HOX2F	Homo sapiens (Human)	251	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; bone marrow development [GO:0048539]; definitive hemopoiesis [GO:0060216]; embryonic skeletal system morphogenesis [GO:0048704]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell proliferation [GO:0071425]; morphogenesis of an epithelial sheet [GO:0002011]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; somatic stem cell division [GO:0048103]; spleen development [GO:0048536]	centrosome [GO:0005813]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	centrosome [GO:0005813]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; bone marrow development [GO:0048539]; definitive hemopoiesis [GO:0060216]; embryonic skeletal system morphogenesis [GO:0048704]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell proliferation [GO:0071425]; morphogenesis of an epithelial sheet [GO:0002011]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; somatic stem cell division [GO:0048103]; spleen development [GO:0048536]	SUBCELLULAR LOCATION: Nucleus.
P17509	reviewed	HXB6_HUMAN	Homeobox protein Hox-B6 (Homeobox protein Hox-2.2) (Homeobox protein Hox-2B) (Homeobox protein Hu-2)	HOXB6 HOX2B	Homo sapiens (Human)	224	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; erythrocyte homeostasis [GO:0034101]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; erythrocyte homeostasis [GO:0034101]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P17516	reviewed	AK1C4_HUMAN	Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha-hydroxysteroid dehydrogenase type I) (3-alpha-HSD1) (EC 1.1.1.357) (3alpha-hydroxysteroid 3-dehydrogenase) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA)	AKR1C4 CHDR	Homo sapiens (Human)	323	FUNCTION: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Liver specific enzyme that acts as NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain (PubMed:14672942, PubMed:10998348, PubMed:7650035, PubMed:1530633, PubMed:11158055, PubMed:10634139, PubMed:19218247). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:14672942). Acts preferentially as a 3-alpha-hydroxysteroid dehydrogenase (HSD) with a subsidiary 3-beta-HSD activity (PubMed:14672942). Catalyzes efficiently the transformation of the potent androgen 5-alpha-dihydrotestosterone (5alpha-DHT or 17beta-hydroxy-5alpha-androstan-3-one) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:11158055, PubMed:10998348, PubMed:14672942). Catalyzes the reduction of estrone into 17beta-estradiol but with low efficiency (PubMed:14672942). Metabolizes a broad spectrum of natural and synthetic therapeutic steroid and plays an important role in metabolism of androgens, estrogens, progestereone and conjugated steroids (PubMed:10998348, PubMed:14672942, PubMed:19218247). Catalyzes the biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leading to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route (PubMed:2427522). {ECO:0000269|PubMed:10634139, ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11158055, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:1530633, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:2427522, ECO:0000269|PubMed:7650035}.		androgen metabolic process [GO:0008209]; bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; cellular response to jasmonic acid stimulus [GO:0071395]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; bile acid transmembrane transporter activity [GO:0015125]; chlordecone reductase activity [GO:0047743]; dihydrotestosterone 17-beta-dehydrogenase activity [GO:0035410]; electron transfer activity [GO:0009055]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; retinal dehydrogenase activity [GO:0001758]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase (NAD+) activity [GO:0047035]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; bile acid transmembrane transporter activity [GO:0015125]; chlordecone reductase activity [GO:0047743]; dihydrotestosterone 17-beta-dehydrogenase activity [GO:0035410]; electron transfer activity [GO:0009055]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; retinal dehydrogenase activity [GO:0001758]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; androgen metabolic process [GO:0008209]; bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; cellular response to jasmonic acid stimulus [GO:0071395]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04828}.
P17535	reviewed	JUND_HUMAN	Transcription factor JunD (Transcription factor AP-1 subunit JunD)	JUND	Homo sapiens (Human)	347	FUNCTION: Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:9989505, PubMed:28981703). {ECO:0000269|PubMed:28981703, ECO:0000269|PubMed:9989505}.		cellular response to calcium ion [GO:0071277]; gene expression [GO:0010467]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast development [GO:0002076]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; cellular response to calcium ion [GO:0071277]; gene expression [GO:0010467]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast development [GO:0002076]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P17540	reviewed	KCRS_HUMAN	Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK)	CKMT2	Homo sapiens (Human)	419	FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.	MISCELLANEOUS: Mitochondrial creatine kinase binds cardiolipin.	muscle contraction [GO:0006936]; phosphocreatine biosynthetic process [GO:0046314]; phosphorylation [GO:0016310]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; muscle contraction [GO:0006936]; phosphocreatine biosynthetic process [GO:0046314]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
P17542	reviewed	TAL1_HUMAN	T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5)	TAL1 BHLHA17 SCL TCL5	Homo sapiens (Human)	331	FUNCTION: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:1396592}.		angiogenesis [GO:0001525]; astrocyte fate commitment [GO:0060018]; basophil differentiation [GO:0030221]; cell fate commitment [GO:0045165]; definitive hemopoiesis [GO:0060216]; embryonic hemopoiesis [GO:0035162]; erythrocyte differentiation [GO:0030218]; erythrocyte maturation [GO:0043249]; hemangioblast cell differentiation [GO:0060217]; hematopoietic stem cell differentiation [GO:0060218]; hemopoiesis [GO:0030097]; locomotory behavior [GO:0007626]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet formation [GO:0030220]; positive regulation of cell division [GO:0051781]; positive regulation of chromatin organization [GO:1905269]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of mast cell differentiation [GO:0060375]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord association neuron differentiation [GO:0021527]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; angiogenesis [GO:0001525]; astrocyte fate commitment [GO:0060018]; basophil differentiation [GO:0030221]; cell fate commitment [GO:0045165]; definitive hemopoiesis [GO:0060216]; embryonic hemopoiesis [GO:0035162]; erythrocyte differentiation [GO:0030218]; erythrocyte maturation [GO:0043249]; hemangioblast cell differentiation [GO:0060217]; hematopoietic stem cell differentiation [GO:0060218]; hemopoiesis [GO:0030097]; locomotory behavior [GO:0007626]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet formation [GO:0030220]; positive regulation of cell division [GO:0051781]; positive regulation of chromatin organization [GO:1905269]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of mast cell differentiation [GO:0060375]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord association neuron differentiation [GO:0021527]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
P17544	reviewed	ATF7_HUMAN	Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A)	ATF7 ATFA	Homo sapiens (Human)	483	FUNCTION: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation (PubMed:29490055). In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (By similarity). Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (By similarity). In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening (PubMed:29490055). Also plays a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (By similarity). {ECO:0000250|UniProtKB:Q8R0S1, ECO:0000269|PubMed:29490055}.; FUNCTION: [Isoform 4]: Acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.; FUNCTION: [Isoform 5]: Acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. {ECO:0000269|PubMed:21858082}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	cAMP response element binding [GO:0035497]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; cAMP response element binding [GO:0035497]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:17264123}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17264123}. Chromosome, telomere {ECO:0000269|PubMed:29490055}. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:21858082}.
P17568	reviewed	NDUB7_HUMAN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (Cell adhesion protein SQM1) (Complex I-B18) (CI-B18) (NADH-ubiquinone oxidoreductase B18 subunit)	NDUFB7	Homo sapiens (Human)	137	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:33502047}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21310150}; Peripheral membrane protein {ECO:0000269|PubMed:21310150}. Mitochondrion intermembrane space {ECO:0000269|PubMed:21310150}.
P17600	reviewed	SYN1_HUMAN	Synapsin-1 (Brain protein 4.1) (Synapsin I)	SYN1	Homo sapiens (Human)	705	FUNCTION: Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}.		chemical synaptic transmission [GO:0007268]; neuron development [GO:0048666]; neurotransmitter secretion [GO:0007269]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of synaptic vesicle exocytosis [GO:2000300]; synapse organization [GO:0050808]; synaptic vesicle clustering [GO:0097091]	axon [GO:0030424]; cell body [GO:0044297]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi apparatus [GO:0005794]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; synaptonemal complex [GO:0000795]	actin binding [GO:0003779]; ATP binding [GO:0005524]; calcium-dependent protein binding [GO:0048306]; cytoskeletal protein-membrane anchor activity [GO:0106006]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]	axon [GO:0030424]; cell body [GO:0044297]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi apparatus [GO:0005794]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; synaptonemal complex [GO:0000795]; actin binding [GO:0003779]; ATP binding [GO:0005524]; calcium-dependent protein binding [GO:0048306]; cytoskeletal protein-membrane anchor activity [GO:0106006]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; chemical synaptic transmission [GO:0007268]; neuron development [GO:0048666]; neurotransmitter secretion [GO:0007269]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of synaptic vesicle exocytosis [GO:2000300]; synapse organization [GO:0050808]; synaptic vesicle clustering [GO:0097091]	SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:O88935}. Golgi apparatus {ECO:0000250|UniProtKB:O88935}. Presynapse {ECO:0000269|PubMed:21441247}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:P09951}. Note=Dissociates from synaptic vesicles and redistributes into the axon during action potential firing, in a step that precedes fusion of vesicles with the plasma membrane. Reclusters to presynapses after the cessation of synaptic activity. {ECO:0000250|UniProtKB:P09951}.
P17612	reviewed	KAPCA_HUMAN	cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)	PRKACA PKACA	Homo sapiens (Human)	351	FUNCTION: Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to cold [GO:0070417]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to heat [GO:0034605]; cellular response to parathyroid hormone stimulus [GO:0071374]; cytokine-mediated signaling pathway [GO:0019221]; high-density lipoprotein particle assembly [GO:0034380]; mesoderm formation [GO:0001707]; mRNA processing [GO:0006397]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; negative regulation of TORC1 signaling [GO:1904262]; neural tube closure [GO:0001843]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein export from nucleus [GO:0046827]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein export from nucleus [GO:0006611]; protein kinase A signaling [GO:0010737]; protein localization to lipid droplet [GO:1990044]; protein phosphorylation [GO:0006468]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell cycle [GO:0051726]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of macroautophagy [GO:0016241]; regulation of osteoblast differentiation [GO:0045667]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein binding [GO:0043393]; regulation of protein processing [GO:0070613]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; renal water homeostasis [GO:0003091]; sperm capacitation [GO:0048240]	acrosomal vesicle [GO:0001669]; calcium channel complex [GO:0034704]; cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]	AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein domain specific binding [GO:0019904]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ubiquitin protein ligase binding [GO:0031625]	acrosomal vesicle [GO:0001669]; calcium channel complex [GO:0034704]; cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein domain specific binding [GO:0019904]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ubiquitin protein ligase binding [GO:0031625]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to cold [GO:0070417]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to heat [GO:0034605]; cellular response to parathyroid hormone stimulus [GO:0071374]; cytokine-mediated signaling pathway [GO:0019221]; high-density lipoprotein particle assembly [GO:0034380]; mesoderm formation [GO:0001707]; mRNA processing [GO:0006397]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; negative regulation of TORC1 signaling [GO:1904262]; neural tube closure [GO:0001843]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein export from nucleus [GO:0046827]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein export from nucleus [GO:0006611]; protein kinase A signaling [GO:0010737]; protein localization to lipid droplet [GO:1990044]; protein phosphorylation [GO:0006468]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell cycle [GO:0051726]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of macroautophagy [GO:0016241]; regulation of osteoblast differentiation [GO:0045667]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein binding [GO:0043393]; regulation of protein processing [GO:0070613]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; renal water homeostasis [GO:0003091]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:19210988, ECO:0000269|PubMed:21423175}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Nucleus {ECO:0000269|PubMed:21085490}. Mitochondrion {ECO:0000250|UniProtKB:P05132}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). Colocalizes with HSF1 in nuclear stress bodies (nSBs) upon heat shock (PubMed:21085490). Recruited to the cell membrane through interaction with SMO (By similarity). {ECO:0000250|UniProtKB:P05132, ECO:0000269|PubMed:21085490}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell projection, cilium, flagellum {ECO:0000269|PubMed:10906071}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P05132}. Note=Expressed in the midpiece region of the sperm flagellum (PubMed:10906071). Colocalizes with MROH2B and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm (By similarity). {ECO:0000250|UniProtKB:P05132, ECO:0000269|PubMed:10906071}.
P17643	reviewed	TYRP1_HUMAN	5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA oxidase) (EC 1.14.18.-) (Catalase B) (Glycoprotein 75) (Melanoma antigen gp75) (Tyrosinase-related protein 1) (TRP) (TRP-1) (TRP1)	TYRP1 CAS2 TYRP TYRRP	Homo sapiens (Human)	537	FUNCTION: Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458, PubMed:23504663). Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity). {ECO:0000250|UniProtKB:P07147, ECO:0000269|PubMed:16704458, ECO:0000269|PubMed:22556244, ECO:0000269|PubMed:23504663, ECO:0000269|PubMed:28661582}.		acetoacetic acid metabolic process [GO:0043438]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; melanosome organization [GO:0032438]; positive regulation of melanin biosynthetic process [GO:0048023]	clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; intracellular vesicle [GO:0097708]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]	metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; protein homodimerization activity [GO:0042803]; tyrosinase activity [GO:0004503]	clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; intracellular vesicle [GO:0097708]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; protein homodimerization activity [GO:0042803]; tyrosinase activity [GO:0004503]; acetoacetic acid metabolic process [GO:0043438]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; melanosome organization [GO:0032438]; positive regulation of melanin biosynthetic process [GO:0048023]	SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000250|UniProtKB:P07147}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P07147}. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250|UniProtKB:P07147}.
P17655	reviewed	CAN2_HUMAN	Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)	CAPN2 CANPL2	Homo sapiens (Human)	700	FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). {ECO:0000250|UniProtKB:O08529, ECO:0000269|PubMed:17650508}.		behavioral response to pain [GO:0048266]; blastocyst development [GO:0001824]; cellular response to amino acid stimulus [GO:0071230]; cellular response to interferon-beta [GO:0035458]; cellular response to lipopolysaccharide [GO:0071222]; female pregnancy [GO:0007565]; myoblast fusion [GO:0007520]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cytoskeleton organization [GO:0051493]; regulation of interleukin-6 production [GO:0032675]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]	calpain complex [GO:0110158]; chromatin [GO:0000785]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type peptidase activity [GO:0008234]; cytoskeletal protein binding [GO:0008092]; enzyme binding [GO:0019899]; protein-containing complex binding [GO:0044877]	calpain complex [GO:0110158]; chromatin [GO:0000785]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type peptidase activity [GO:0008234]; cytoskeletal protein binding [GO:0008092]; enzyme binding [GO:0019899]; protein-containing complex binding [GO:0044877]; behavioral response to pain [GO:0048266]; blastocyst development [GO:0001824]; cellular response to amino acid stimulus [GO:0071230]; cellular response to interferon-beta [GO:0035458]; cellular response to lipopolysaccharide [GO:0071222]; female pregnancy [GO:0007565]; myoblast fusion [GO:0007520]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cytoskeleton organization [GO:0051493]; regulation of interleukin-6 production [GO:0032675]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.
P17658	reviewed	KCNA6_HUMAN	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel HBK2) (Voltage-gated potassium channel subunit Kv1.6)	KCNA6	Homo sapiens (Human)	529	FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305). {ECO:0000250|UniProtKB:P17659, ECO:0000269|PubMed:14575698, ECO:0000269|PubMed:2347305}.		potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	axon terminus [GO:0043679]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14575698, ECO:0000269|PubMed:2347305}; Multi-pass membrane protein {ECO:0000305}.
P17661	reviewed	DESM_HUMAN	Desmin	DES	Homo sapiens (Human)	470	FUNCTION: Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}.		cytoskeleton organization [GO:0007010]; intermediate filament organization [GO:0045109]; muscle contraction [GO:0006936]; regulation of heart contraction [GO:0008016]; skeletal muscle organ development [GO:0060538]	cardiac myofibril [GO:0097512]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fascia adherens [GO:0005916]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; sarcolemma [GO:0042383]; Z disc [GO:0030018]	cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200]	cardiac myofibril [GO:0097512]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fascia adherens [GO:0005916]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; sarcolemma [GO:0042383]; Z disc [GO:0030018]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200]; cytoskeleton organization [GO:0007010]; intermediate filament organization [GO:0045109]; muscle contraction [GO:0006936]; regulation of heart contraction [GO:0008016]; skeletal muscle organ development [GO:0060538]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:26724190, ECO:0000269|PubMed:30262925}. Cytoplasm {ECO:0000269|PubMed:25394388}. Cell membrane, sarcolemma {ECO:0000269|PubMed:25394388}. Nucleus {ECO:0000250|UniProtKB:P31001}. Note=Localizes in the intercalated disks which occur at the Z line of cardiomyocytes (PubMed:24200904, PubMed:26724190). Localizes in the nucleus exclusively in differentiating cardiac progenitor cells and premature cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:26724190}.
P17676	reviewed	CEBPB_HUMAN	CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5)	CEBPB TCF5 PP9092	Homo sapiens (Human)	345	FUNCTION: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}.		acute-phase response [GO:0006953]; brown fat cell differentiation [GO:0050873]; cellular response to amino acid stimulus [GO:0071230]; defense response to bacterium [GO:0042742]; embryonic placenta development [GO:0001892]; granuloma formation [GO:0002432]; hepatocyte proliferation [GO:0072574]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrated stress response signaling [GO:0140467]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; liver regeneration [GO:0097421]; mammary gland epithelial cell differentiation [GO:0060644]; mammary gland epithelial cell proliferation [GO:0033598]; myeloid cell development [GO:0061515]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; ovarian follicle development [GO:0001541]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of sodium-dependent phosphate transport [GO:2000120]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; regulation of cell differentiation [GO:0045595]; regulation of dendritic cell differentiation [GO:2001198]; regulation of DNA-templated transcription [GO:0006355]; regulation of interleukin-6 production [GO:0032675]; regulation of odontoblast differentiation [GO:1901329]; regulation of osteoclast differentiation [GO:0045670]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to lipopolysaccharide [GO:0032496]; T-helper 1 cell activation [GO:0035711]; transcription by RNA polymerase II [GO:0006366]	C/EBP complex [GO:1990647]; CHOP-C/EBP complex [GO:0036488]; chromatin [GO:0000785]; condensed chromosome, centromeric region [GO:0000779]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; kinase binding [GO:0019900]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin-like protein ligase binding [GO:0044389]	C/EBP complex [GO:1990647]; CHOP-C/EBP complex [GO:0036488]; chromatin [GO:0000785]; condensed chromosome, centromeric region [GO:0000779]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; kinase binding [GO:0019900]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin-like protein ligase binding [GO:0044389]; acute-phase response [GO:0006953]; brown fat cell differentiation [GO:0050873]; cellular response to amino acid stimulus [GO:0071230]; defense response to bacterium [GO:0042742]; embryonic placenta development [GO:0001892]; granuloma formation [GO:0002432]; hepatocyte proliferation [GO:0072574]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrated stress response signaling [GO:0140467]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; liver regeneration [GO:0097421]; mammary gland epithelial cell differentiation [GO:0060644]; mammary gland epithelial cell proliferation [GO:0033598]; myeloid cell development [GO:0061515]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; ovarian follicle development [GO:0001541]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of sodium-dependent phosphate transport [GO:2000120]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; regulation of cell differentiation [GO:0045595]; regulation of dendritic cell differentiation [GO:2001198]; regulation of DNA-templated transcription [GO:0006355]; regulation of interleukin-6 production [GO:0032675]; regulation of odontoblast differentiation [GO:1901329]; regulation of osteoclast differentiation [GO:0045670]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to lipopolysaccharide [GO:0032496]; T-helper 1 cell activation [GO:0035711]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20829347}. Cytoplasm {ECO:0000269|PubMed:9374525}. Note=Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity). {ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:9374525}.
P17677	reviewed	NEUM_HUMAN	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46)	GAP43	Homo sapiens (Human)	238	FUNCTION: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}.		astrocyte differentiation [GO:0048708]; axon choice point recognition [GO:0016198]; axon regeneration [GO:0031103]; cell fate commitment [GO:0045165]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; radial glial cell differentiation [GO:0060019]; regulation of filopodium assembly [GO:0051489]; regulation of growth [GO:0040008]; regulation of postsynaptic specialization assembly [GO:0099150]; response to wounding [GO:0009611]; tissue regeneration [GO:0042246]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; filopodium membrane [GO:0031527]; GABA-ergic synapse [GO:0098982]; growth cone membrane [GO:0032584]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]	calmodulin binding [GO:0005516]; lysophosphatidic acid binding [GO:0035727]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylserine binding [GO:0001786]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; filopodium membrane [GO:0031527]; GABA-ergic synapse [GO:0098982]; growth cone membrane [GO:0032584]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; calmodulin binding [GO:0005516]; lysophosphatidic acid binding [GO:0035727]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylserine binding [GO:0001786]; astrocyte differentiation [GO:0048708]; axon choice point recognition [GO:0016198]; axon regeneration [GO:0031103]; cell fate commitment [GO:0045165]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; radial glial cell differentiation [GO:0060019]; regulation of filopodium assembly [GO:0051489]; regulation of growth [GO:0040008]; regulation of postsynaptic specialization assembly [GO:0099150]; response to wounding [GO:0009611]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14978216}; Peripheral membrane protein {ECO:0000269|PubMed:14978216}; Cytoplasmic side {ECO:0000269|PubMed:14978216}. Cell projection, growth cone membrane {ECO:0000269|PubMed:14978216}; Peripheral membrane protein {ECO:0000269|PubMed:14978216}; Cytoplasmic side {ECO:0000269|PubMed:14978216}. Synapse {ECO:0000269|PubMed:14978216}. Cell projection, filopodium membrane {ECO:0000269|PubMed:14978216}; Peripheral membrane protein {ECO:0000269|PubMed:14978216}. Perikaryon {ECO:0000250|UniProtKB:P07936}. Cell projection, dendrite {ECO:0000250|UniProtKB:P07936}. Cell projection, axon {ECO:0000250|UniProtKB:P07936}. Cytoplasm {ECO:0000250|UniProtKB:P07936}. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes. {ECO:0000269|PubMed:14978216}.
P17693	reviewed	HLAG_HUMAN	HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)]	HLA-G HLA-6.0 HLAG	Homo sapiens (Human)	338	FUNCTION: [Isoform 1]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110, PubMed:27859042). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799). Through interaction with KIR2DL4 receptor on decidual macrophages induces pro-inflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:11290782, PubMed:24453251). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251). May induce immune activation/suppression via intercellular membrane transfer (trogocytosis), likely enabling interaction with KIR2DL4, which resides mostly in endosomes (PubMed:20179272, PubMed:26460007). Through interaction with the inhibitory receptor CD160 on endothelial cells may control angiogenesis in immune privileged sites (PubMed:16809620). {ECO:0000269|PubMed:10190900, ECO:0000269|PubMed:11290782, ECO:0000269|PubMed:16366734, ECO:0000269|PubMed:16809620, ECO:0000269|PubMed:19304799, ECO:0000269|PubMed:20179272, ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:23184984, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:26460007, ECO:0000269|PubMed:27859042, ECO:0000269|PubMed:29262349, ECO:0000269|PubMed:7584149, ECO:0000269|PubMed:8805247}.; FUNCTION: [Isoform 2]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782). {ECO:0000269|PubMed:11290782, ECO:0000305}.; FUNCTION: [Isoform 3]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782). {ECO:0000269|PubMed:11290782, ECO:0000305}.; FUNCTION: [Isoform 4]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782). {ECO:0000269|PubMed:11290782, ECO:0000305}.; FUNCTION: [Isoform 5]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799). Through interaction with KIR2DL4 receptor on decidual macrophages induces pro-inflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251). {ECO:0000269|PubMed:16366734, ECO:0000269|PubMed:19304799, ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:23184984, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:29262349, ECO:0000269|PubMed:7584149, ECO:0000269|PubMed:8805247}.; FUNCTION: [Isoform 6]: Likely does not bind B2M and presents peptides. {ECO:0000305}.; FUNCTION: [Isoform 7]: Likely does not bind B2M and presents peptides. {ECO:0000305}.		antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; cellular defense response [GO:0006968]; immune response [GO:0006955]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; negative regulation of angiogenesis [GO:0016525]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of immune response [GO:0050777]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell proliferation [GO:0042130]; peripheral B cell tolerance induction [GO:0002451]; positive regulation of cellular senescence [GO:2000774]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction [GO:0002645]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; protein homotrimerization [GO:0070207]	cis-Golgi network membrane [GO:0033106]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; filopodium membrane [GO:0031527]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	CD8 receptor binding [GO:0042610]; identical protein binding [GO:0042802]; peptide antigen binding [GO:0042605]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]	cis-Golgi network membrane [GO:0033106]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; filopodium membrane [GO:0031527]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; CD8 receptor binding [GO:0042610]; identical protein binding [GO:0042802]; peptide antigen binding [GO:0042605]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; cellular defense response [GO:0006968]; immune response [GO:0006955]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; negative regulation of angiogenesis [GO:0016525]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of immune response [GO:0050777]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell proliferation [GO:0042130]; peripheral B cell tolerance induction [GO:0002451]; positive regulation of cellular senescence [GO:2000774]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction [GO:0002645]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; protein homotrimerization [GO:0070207]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:7584149}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11520457}. Early endosome membrane {ECO:0000269|PubMed:16366734}.; SUBCELLULAR LOCATION: [Soluble HLA class I histocompatibility antigen, alpha chain G]: Secreted {ECO:0000269|PubMed:23737137}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11290782}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:11290782}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:11290782}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000269|PubMed:11137219, ECO:0000269|PubMed:7558941, ECO:0000269|PubMed:7584149, ECO:0000269|PubMed:7989753}. Early endosome {ECO:0000269|PubMed:16366734}.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted {ECO:0000269|PubMed:7989753}.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted {ECO:0000269|PubMed:11137219}.; SUBCELLULAR LOCATION: Cell projection, filopodium membrane {ECO:0000269|PubMed:26460007}. Note=HLA-G trogocytosis from extravillous trophoblast's filopodia occurs in the majority of decidual NK cells. {ECO:0000269|PubMed:26460007}.
P17706	reviewed	PTN2_HUMAN	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP)	PTPN2 PTPT	Homo sapiens (Human)	415	FUNCTION: Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA. {ECO:0000269|PubMed:10734133, ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12138178, ECO:0000269|PubMed:12612081, ECO:0000269|PubMed:14966296, ECO:0000269|PubMed:15592458, ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:9488479}.	MISCELLANEOUS: [Isoform 1]: Minor isoform.; MISCELLANEOUS: [Isoform 2]: Major isoform. Contains a nuclear location signal at positions 377-381 (PubMed:7593185) and an autoinhibitory region acting through intramolecular interactions is found at positions 353-387. {ECO:0000269|PubMed:15030318, ECO:0000305|PubMed:7593185}.	B cell differentiation [GO:0030183]; erythrocyte differentiation [GO:0030218]; glucose homeostasis [GO:0042593]; insulin receptor recycling [GO:0038020]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of interleukin-2-mediated signaling pathway [GO:1902206]; negative regulation of interleukin-4-mediated signaling pathway [GO:1902215]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage colony-stimulating factor signaling pathway [GO:1902227]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of positive thymic T cell selection [GO:1902233]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; regulation of hepatocyte growth factor receptor signaling pathway [GO:1902202]; regulation of type II interferon-mediated signaling pathway [GO:0060334]; T cell differentiation [GO:0030217]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome lumen [GO:0031904]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; STAT family protein binding [GO:0097677]; syntaxin binding [GO:0019905]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome lumen [GO:0031904]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; STAT family protein binding [GO:0097677]; syntaxin binding [GO:0019905]; B cell differentiation [GO:0030183]; erythrocyte differentiation [GO:0030218]; glucose homeostasis [GO:0042593]; insulin receptor recycling [GO:0038020]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of interleukin-2-mediated signaling pathway [GO:1902206]; negative regulation of interleukin-4-mediated signaling pathway [GO:1902215]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage colony-stimulating factor signaling pathway [GO:1902227]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of positive thymic T cell selection [GO:1902233]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; regulation of hepatocyte growth factor receptor signaling pathway [GO:1902202]; regulation of type II interferon-mediated signaling pathway [GO:0060334]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum {ECO:0000269|PubMed:7593185}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:7593185}. Note=Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region. {ECO:0000269|PubMed:7593185}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localizes to chromatin (By similarity). Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors (PubMed:9488479). Recruited by activated ITGA1 at the plasma membrane. {ECO:0000250, ECO:0000269|PubMed:9488479}.
P17707	reviewed	DCAM_HUMAN	S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain]	AMD1 AMD	Homo sapiens (Human)	334	FUNCTION: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000250|UniProtKB:P0DMN7}.		polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597]	cytosol [GO:0005829]	adenosylmethionine decarboxylase activity [GO:0004014]; identical protein binding [GO:0042802]; putrescine binding [GO:0019810]	cytosol [GO:0005829]; adenosylmethionine decarboxylase activity [GO:0004014]; identical protein binding [GO:0042802]; putrescine binding [GO:0019810]; polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597]	
P17735	reviewed	ATTY_HUMAN	Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase)	TAT	Homo sapiens (Human)	454	FUNCTION: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. {ECO:0000269|PubMed:16640556, ECO:0000269|PubMed:7999802}.		2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; glutamate metabolic process [GO:0006536]; L-phenylalanine catabolic process [GO:0006559]; response to dexamethasone [GO:0071548]; response to mercury ion [GO:0046689]; response to oxidative stress [GO:0006979]; tyrosine catabolic process [GO:0006572]	cytosol [GO:0005829]	amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; L-tyrosine:2-oxoglutarate aminotransferase activity [GO:0004838]; pyridoxal phosphate binding [GO:0030170]	cytosol [GO:0005829]; amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; L-tyrosine:2-oxoglutarate aminotransferase activity [GO:0004838]; pyridoxal phosphate binding [GO:0030170]; 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; glutamate metabolic process [GO:0006536]; L-phenylalanine catabolic process [GO:0006559]; response to dexamethasone [GO:0071548]; response to mercury ion [GO:0046689]; response to oxidative stress [GO:0006979]; tyrosine catabolic process [GO:0006572]	
P17752	reviewed	TPH1_HUMAN	Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1)	TPH1 TPH TPRH TRPH	Homo sapiens (Human)	444	FUNCTION: Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. {ECO:0000250|UniProtKB:P17532}.		aromatic amino acid metabolic process [GO:0009072]; bone remodeling [GO:0046849]; circadian rhythm [GO:0007623]; mammary gland alveolus development [GO:0060749]; negative regulation of ossification [GO:0030279]; platelet degranulation [GO:0002576]; positive regulation of fat cell differentiation [GO:0045600]; regulation of hemostasis [GO:1900046]; response to immobilization stress [GO:0035902]; serotonin biosynthetic process [GO:0042427]	cytosol [GO:0005829]; neuron projection [GO:0043005]	iron ion binding [GO:0005506]; tryptophan 5-monooxygenase activity [GO:0004510]	cytosol [GO:0005829]; neuron projection [GO:0043005]; iron ion binding [GO:0005506]; tryptophan 5-monooxygenase activity [GO:0004510]; aromatic amino acid metabolic process [GO:0009072]; bone remodeling [GO:0046849]; circadian rhythm [GO:0007623]; mammary gland alveolus development [GO:0060749]; negative regulation of ossification [GO:0030279]; platelet degranulation [GO:0002576]; positive regulation of fat cell differentiation [GO:0045600]; regulation of hemostasis [GO:1900046]; response to immobilization stress [GO:0035902]; serotonin biosynthetic process [GO:0042427]	
P17787	reviewed	ACHB2_HUMAN	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	Homo sapiens (Human)	502	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. {ECO:0000269|PubMed:22361591}.		acetylcholine receptor signaling pathway [GO:0095500]; associative learning [GO:0008306]; B cell activation [GO:0042113]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; central nervous system projection neuron axonogenesis [GO:0021952]; cognition [GO:0050890]; lateral geniculate nucleus development [GO:0021771]; learning [GO:0007612]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; memory [GO:0007613]; monoatomic ion transport [GO:0006811]; negative regulation of action potential [GO:0045759]; nervous system process [GO:0050877]; optic nerve morphogenesis [GO:0021631]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of dopamine secretion [GO:0033603]; regulation of circadian sleep/wake cycle, REM sleep [GO:0042320]; regulation of dendrite morphogenesis [GO:0048814]; regulation of dopamine metabolic process [GO:0042053]; regulation of dopamine secretion [GO:0014059]; regulation of synapse assembly [GO:0051963]; regulation of synaptic transmission, dopaminergic [GO:0032225]; response to acetylcholine [GO:1905144]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; sensory perception of pain [GO:0019233]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]; social behavior [GO:0035176]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]; vestibulocochlear nerve development [GO:0021562]; visual learning [GO:0008542]; visual perception [GO:0007601]	acetylcholine-gated channel complex [GO:0005892]; cholinergic synapse [GO:0098981]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; heterocyclic compound binding [GO:1901363]; ligand-gated monoatomic ion channel activity [GO:0015276]; protein-containing complex binding [GO:0044877]	acetylcholine-gated channel complex [GO:0005892]; cholinergic synapse [GO:0098981]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; heterocyclic compound binding [GO:1901363]; ligand-gated monoatomic ion channel activity [GO:0015276]; protein-containing complex binding [GO:0044877]; acetylcholine receptor signaling pathway [GO:0095500]; associative learning [GO:0008306]; B cell activation [GO:0042113]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; central nervous system projection neuron axonogenesis [GO:0021952]; cognition [GO:0050890]; lateral geniculate nucleus development [GO:0021771]; learning [GO:0007612]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; memory [GO:0007613]; monoatomic ion transport [GO:0006811]; negative regulation of action potential [GO:0045759]; nervous system process [GO:0050877]; optic nerve morphogenesis [GO:0021631]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of dopamine secretion [GO:0033603]; regulation of circadian sleep/wake cycle, REM sleep [GO:0042320]; regulation of dendrite morphogenesis [GO:0048814]; regulation of dopamine metabolic process [GO:0042053]; regulation of dopamine secretion [GO:0014059]; regulation of synapse assembly [GO:0051963]; regulation of synaptic transmission, dopaminergic [GO:0032225]; response to acetylcholine [GO:1905144]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; sensory perception of pain [GO:0019233]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]; social behavior [GO:0035176]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]; vestibulocochlear nerve development [GO:0021562]; visual learning [GO:0008542]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
P17812	reviewed	PYRG1_HUMAN	CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1)	CTPS1 CTPS	Homo sapiens (Human)	591	FUNCTION: This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. {ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:24870241}.		'de novo' CTP biosynthetic process [GO:0044210]; B cell proliferation [GO:0042100]; CTP biosynthetic process [GO:0006241]; glutamine metabolic process [GO:0006541]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleobase biosynthetic process [GO:0019856]; response to xenobiotic stimulus [GO:0009410]; T cell proliferation [GO:0042098]	cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802]	cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802]; 'de novo' CTP biosynthetic process [GO:0044210]; B cell proliferation [GO:0042100]; CTP biosynthetic process [GO:0006241]; glutamine metabolic process [GO:0006541]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleobase biosynthetic process [GO:0019856]; response to xenobiotic stimulus [GO:0009410]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25223282}. Note=Mainly cytosolic but when active detected in long filamentous structures (PubMed:25223282). Co-localizes with TNK2 in the cytosolic filaments (By similarity). {ECO:0000250|UniProtKB:P70698, ECO:0000269|PubMed:25223282}.
P17813	reviewed	EGLN_HUMAN	Endoglin (CD antigen CD105)	ENG END	Homo sapiens (Human)	658	FUNCTION: Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529). {ECO:0000250|UniProtKB:Q63961, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:21737454, ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:7894484, ECO:0000269|PubMed:8370410, ECO:0000305|PubMed:1692830}.		artery morphogenesis [GO:0048844]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; atrioventricular canal morphogenesis [GO:1905222]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac atrium morphogenesis [GO:0003209]; cardiac ventricle morphogenesis [GO:0003208]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell migration involved in endocardial cushion formation [GO:0003273]; cell motility [GO:0048870]; cellular response to mechanical stimulus [GO:0071260]; central nervous system vasculogenesis [GO:0022009]; detection of hypoxia [GO:0070483]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion morphogenesis [GO:0003203]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; extracellular matrix constituent secretion [GO:0070278]; extracellular matrix disassembly [GO:0022617]; heart looping [GO:0001947]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of phosphorylation [GO:0042325]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060]	cell surface [GO:0009986]; endothelial microparticle [GO:0072563]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	activin binding [GO:0048185]; coreceptor activity [GO:0015026]; galactose binding [GO:0005534]; glycosaminoglycan binding [GO:0005539]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transmembrane signaling receptor activity [GO:0004888]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]	cell surface [GO:0009986]; endothelial microparticle [GO:0072563]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; activin binding [GO:0048185]; coreceptor activity [GO:0015026]; galactose binding [GO:0005534]; glycosaminoglycan binding [GO:0005539]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transmembrane signaling receptor activity [GO:0004888]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; artery morphogenesis [GO:0048844]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; atrioventricular canal morphogenesis [GO:1905222]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac atrium morphogenesis [GO:0003209]; cardiac ventricle morphogenesis [GO:0003208]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell migration involved in endocardial cushion formation [GO:0003273]; cell motility [GO:0048870]; cellular response to mechanical stimulus [GO:0071260]; central nervous system vasculogenesis [GO:0022009]; detection of hypoxia [GO:0070483]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion morphogenesis [GO:0003203]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; extracellular matrix constituent secretion [GO:0070278]; extracellular matrix disassembly [GO:0022617]; heart looping [GO:0001947]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of phosphorylation [GO:0042325]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10545596, ECO:0000269|PubMed:1326540, ECO:0000269|PubMed:1692830, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:8370410}; Single-pass type I membrane protein {ECO:0000305|PubMed:1692830, ECO:0000305|PubMed:8370410}.
P17844	reviewed	DDX5_HUMAN	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)	DDX5 G17P1 HELR HLR1	Homo sapiens (Human)	614	FUNCTION: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}.		alternative mRNA splicing, via spliceosome [GO:0000380]; androgen receptor signaling pathway [GO:0030521]; BMP signaling pathway [GO:0030509]; epithelial to mesenchymal transition [GO:0001837]; intracellular estrogen receptor signaling pathway [GO:0030520]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; miRNA transcription [GO:0061614]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription [GO:0009299]; myoblast differentiation [GO:0045445]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; primary miRNA processing [GO:0031053]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of osteoblast differentiation [GO:0045667]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of viral genome replication [GO:0045069]; rhythmic process [GO:0048511]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; MH2 domain binding [GO:0035500]; mRNA 3'-UTR binding [GO:0003730]; nuclear androgen receptor binding [GO:0050681]; pre-mRNA binding [GO:0036002]; primary miRNA binding [GO:0070878]; promoter-specific chromatin binding [GO:1990841]; R-SMAD binding [GO:0070412]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; SMAD binding [GO:0046332]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; MH2 domain binding [GO:0035500]; mRNA 3'-UTR binding [GO:0003730]; nuclear androgen receptor binding [GO:0050681]; pre-mRNA binding [GO:0036002]; primary miRNA binding [GO:0070878]; promoter-specific chromatin binding [GO:1990841]; R-SMAD binding [GO:0070412]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; SMAD binding [GO:0046332]; alternative mRNA splicing, via spliceosome [GO:0000380]; androgen receptor signaling pathway [GO:0030521]; BMP signaling pathway [GO:0030509]; epithelial to mesenchymal transition [GO:0001837]; intracellular estrogen receptor signaling pathway [GO:0030520]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; miRNA transcription [GO:0061614]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription [GO:0009299]; myoblast differentiation [GO:0045445]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; primary miRNA processing [GO:0031053]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of osteoblast differentiation [GO:0045667]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of viral genome replication [GO:0045069]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22034099}. Nucleus, nucleolus {ECO:0000269|PubMed:10837141, ECO:0000269|PubMed:1996094}. Nucleus speckle {ECO:0000269|PubMed:24644279}. Cytoplasm {ECO:0000269|PubMed:22034099}. Note=During the G0 phase, predominantly located in the nucleus. Cytoplasmic levels increase during the G1/S phase. During the M phase, located at the vicinity of the condensed chromosomes. At G1, localizes in the cytoplasm. {ECO:0000269|PubMed:22034099}.
P17858	reviewed	PFKAL_HUMAN	ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)	PFKL	Homo sapiens (Human)	780	FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). {ECO:0000250|UniProtKB:P12382, ECO:0000255|HAMAP-Rule:MF_03184, ECO:0000269|PubMed:22923583}.	MISCELLANEOUS: In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes.; MISCELLANEOUS: Glycosylation may play a role in cancer cell proliferation: inhibition of 6-phosphofructokinase activity and subsequent redirection of the glucose flux through the oxidative pentose phosphate pathway confers a selective growth advantage on cancer cells. Moreover GlcNAcylation is observed in multiple cancer cell lines and tissue samples and GlcNAcylation leads to larger xenografts tunors in mice (PubMed:22923583). {ECO:0000305|PubMed:22923583}.	canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glycolytic process [GO:0006096]; negative regulation of insulin secretion [GO:0046676]; response to glucose [GO:0009749]	6-phosphofructokinase complex [GO:0005945]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]	6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; fructose binding [GO:0070061]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]	6-phosphofructokinase complex [GO:0005945]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]; 6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; fructose binding [GO:0070061]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]; canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glycolytic process [GO:0006096]; negative regulation of insulin secretion [GO:0046676]; response to glucose [GO:0009749]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
P17861	reviewed	XBP1_HUMAN	X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]	XBP1 TREB5 XBP2	Homo sapiens (Human)	261	FUNCTION: Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:8349596}.; FUNCTION: [Isoform 1]: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:2321018, PubMed:2196176, PubMed:1903538, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:1903538, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:21233347, ECO:0000269|PubMed:2196176, ECO:0000269|PubMed:2321018, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:8657566}.; FUNCTION: [Isoform 2]: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Improves also glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:15466483, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:25280941}.	MISCELLANEOUS: [Isoform 2]: Potent transcriptional activator. Induced by unconventional ERN1-dependent splicing in response to endoplasmic reticulum stress (PubMed:11779464, PubMed:19622636, PubMed:19394296). ERN1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript (PubMed:11779464). {ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:19622636}.	adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; ATF6-mediated unfolded protein response [GO:0036500]; autophagy [GO:0006914]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cholesterol homeostasis [GO:0042632]; endoplasmic reticulum unfolded protein response [GO:0030968]; endothelial cell proliferation [GO:0001935]; ERAD pathway [GO:0036503]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; immune response [GO:0006955]; intracellular triglyceride homeostasis [GO:0035356]; IRE1-mediated unfolded protein response [GO:0036498]; liver development [GO:0001889]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron development [GO:0048666]; organelle organization [GO:0006996]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of histone methylation [GO:0031062]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipid biosynthetic process [GO:0071073]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular wound healing [GO:0035470]; protein destabilization [GO:0031648]; protein transport [GO:0015031]; regulation of cell growth [GO:0001558]; regulation of protein stability [GO:0031647]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; sterol homeostasis [GO:0055092]; transcription by RNA polymerase II [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin DNA binding [GO:0031490]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin DNA binding [GO:0031490]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; ATF6-mediated unfolded protein response [GO:0036500]; autophagy [GO:0006914]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cholesterol homeostasis [GO:0042632]; endoplasmic reticulum unfolded protein response [GO:0030968]; endothelial cell proliferation [GO:0001935]; ERAD pathway [GO:0036503]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; immune response [GO:0006955]; intracellular triglyceride homeostasis [GO:0035356]; IRE1-mediated unfolded protein response [GO:0036498]; liver development [GO:0001889]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron development [GO:0048666]; organelle organization [GO:0006996]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of histone methylation [GO:0031062]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipid biosynthetic process [GO:0071073]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular wound healing [GO:0035470]; protein destabilization [GO:0031648]; protein transport [GO:0015031]; regulation of cell growth [GO:0001558]; regulation of protein stability [GO:0031647]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; sterol homeostasis [GO:0055092]; transcription by RNA polymerase II [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:23529610}. Note=Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). {ECO:0000269|PubMed:23529610}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296}. Cytoplasm {ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:25190803}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25239945}; Single-pass type II membrane protein {ECO:0000269|PubMed:25239945}. Endoplasmic reticulum membrane {ECO:0000303|PubMed:25239945}; Peripheral membrane protein {ECO:0000303|PubMed:25239945}. Membrane {ECO:0000269|PubMed:19394296}; Peripheral membrane protein {ECO:0000303|PubMed:19394296}. Note=Shows no preferential localization to either the nucleus or the cytoplasm (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:16461360). Localizes predominantly at the endoplasmic reticulum membrane as a membrane-spanning protein; whereas may be only marginally localized on the cytosolic side of the ER membrane as a peripheral membrane (PubMed:19394296, PubMed:25190803). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:25190803}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:20955178}. Cytoplasm {ECO:0000250|UniProtKB:O35426}. Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin-dependent manner (By similarity). {ECO:0000250|UniProtKB:O35426}.; SUBCELLULAR LOCATION: [X-box-binding protein 1, cytoplasmic form]: Cytoplasm {ECO:0000269|PubMed:25239945}. Nucleus {ECO:0000269|PubMed:25239945}. Note=Localizes in the cytoplasm and nucleus after HM13/SPP-mediated intramembranaire proteolytic cleavage of isoform 1 (PubMed:25239945). {ECO:0000269|PubMed:25239945}.
P17900	reviewed	SAP3_HUMAN	Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) [Cleaved into: Ganglioside GM2 activator isoform short]	GM2A	Homo sapiens (Human)	193	FUNCTION: The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (By similarity). Has cholesterol transfer activity (PubMed:17552909). {ECO:0000250|UniProtKB:Q60648, ECO:0000269|PubMed:17552909}.		ganglioside catabolic process [GO:0006689]; glycosphingolipid metabolic process [GO:0006687]; learning or memory [GO:0007611]; lipid storage [GO:0019915]; lipid transport [GO:0006869]; maintenance of location in cell [GO:0051651]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]	apical plasma membrane [GO:0016324]; azurophil granule lumen [GO:0035578]; basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]	beta-N-acetylgalactosaminidase activity [GO:0032428]; lipid transporter activity [GO:0005319]; phospholipase activator activity [GO:0016004]; sphingolipid activator protein activity [GO:0030290]	apical plasma membrane [GO:0016324]; azurophil granule lumen [GO:0035578]; basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; beta-N-acetylgalactosaminidase activity [GO:0032428]; lipid transporter activity [GO:0005319]; phospholipase activator activity [GO:0016004]; sphingolipid activator protein activity [GO:0030290]; ganglioside catabolic process [GO:0006689]; glycosphingolipid metabolic process [GO:0006687]; learning or memory [GO:0007611]; lipid storage [GO:0019915]; lipid transport [GO:0006869]; maintenance of location in cell [GO:0051651]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]	SUBCELLULAR LOCATION: Lysosome.
P17927	reviewed	CR1_HUMAN	Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)	CR1 C3BR	Homo sapiens (Human)	2039	FUNCTION: Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728). {ECO:0000269|PubMed:25742728, ECO:0000269|PubMed:2963069, ECO:0000269|PubMed:2972794, ECO:0000269|PubMed:8175757}.; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus. {ECO:0000269|PubMed:23416052}.		ATP export [GO:1904669]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; complement receptor mediated signaling pathway [GO:0002430]; immune complex clearance by erythrocytes [GO:0002435]; negative regulation of activation of membrane attack complex [GO:0001971]; negative regulation of complement activation [GO:0045916]; negative regulation of complement activation, alternative pathway [GO:0045957]; negative regulation of complement activation, classical pathway [GO:0045959]; negative regulation of complement-dependent cytotoxicity [GO:1903660]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of plasma cell differentiation [GO:1900099]; negative regulation of serine-type endopeptidase activity [GO:1900004]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type II interferon production [GO:0032689]; plasma membrane organization [GO:0007009]; positive regulation of activation of membrane attack complex [GO:0001970]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of serine-type endopeptidase activity [GO:1900005]; T cell mediated immunity [GO:0002456]	cell surface [GO:0009986]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; secretory granule membrane [GO:0030667]	complement component C3b binding [GO:0001851]; complement component C3b receptor activity [GO:0004877]; complement component C4b binding [GO:0001855]; complement component C4b receptor activity [GO:0001861]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; secretory granule membrane [GO:0030667]; complement component C3b binding [GO:0001851]; complement component C3b receptor activity [GO:0004877]; complement component C4b binding [GO:0001855]; complement component C4b receptor activity [GO:0001861]; virus receptor activity [GO:0001618]; ATP export [GO:1904669]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; complement receptor mediated signaling pathway [GO:0002430]; immune complex clearance by erythrocytes [GO:0002435]; negative regulation of activation of membrane attack complex [GO:0001971]; negative regulation of complement activation [GO:0045916]; negative regulation of complement activation, alternative pathway [GO:0045957]; negative regulation of complement activation, classical pathway [GO:0045959]; negative regulation of complement-dependent cytotoxicity [GO:1903660]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of plasma cell differentiation [GO:1900099]; negative regulation of serine-type endopeptidase activity [GO:1900004]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type II interferon production [GO:0032689]; plasma membrane organization [GO:0007009]; positive regulation of activation of membrane attack complex [GO:0001970]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of serine-type endopeptidase activity [GO:1900005]; T cell mediated immunity [GO:0002456]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:1385479}; Single-pass type I membrane protein.
P17931	reviewed	LEG3_HUMAN	Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen)	LGALS3 MAC2	Homo sapiens (Human)	250	FUNCTION: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. {ECO:0000250, ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:19594635, ECO:0000269|PubMed:19616076, ECO:0000269|PubMed:27693506}.		eosinophil chemotaxis [GO:0048245]; epithelial cell differentiation [GO:0030855]; innate immune response [GO:0045087]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; mononuclear cell migration [GO:0071674]; mRNA processing [GO:0006397]; negative regulation of endocytosis [GO:0045806]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of immunological synapse formation [GO:2000521]; negative regulation of protein tyrosine phosphatase activity [GO:1903614]; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001189]; negative regulation of T cell receptor signaling pathway [GO:0050860]; neutrophil chemotaxis [GO:0030593]; positive chemotaxis [GO:0050918]; positive regulation of calcium ion import [GO:0090280]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of T cell apoptotic process [GO:0070232]; regulation of T cell proliferation [GO:0042129]; RNA splicing [GO:0008380]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; immunological synapse [GO:0001772]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; spliceosomal complex [GO:0005681]	carbohydrate binding [GO:0030246]; chemoattractant activity [GO:0042056]; IgE binding [GO:0019863]; laminin binding [GO:0043236]; molecular condensate scaffold activity [GO:0140693]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; RNA binding [GO:0003723]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; immunological synapse [GO:0001772]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; spliceosomal complex [GO:0005681]; carbohydrate binding [GO:0030246]; chemoattractant activity [GO:0042056]; IgE binding [GO:0019863]; laminin binding [GO:0043236]; molecular condensate scaffold activity [GO:0140693]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; RNA binding [GO:0003723]; eosinophil chemotaxis [GO:0048245]; epithelial cell differentiation [GO:0030855]; innate immune response [GO:0045087]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; mononuclear cell migration [GO:0071674]; mRNA processing [GO:0006397]; negative regulation of endocytosis [GO:0045806]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of immunological synapse formation [GO:2000521]; negative regulation of protein tyrosine phosphatase activity [GO:1903614]; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001189]; negative regulation of T cell receptor signaling pathway [GO:0050860]; neutrophil chemotaxis [GO:0030593]; positive chemotaxis [GO:0050918]; positive regulation of calcium ion import [GO:0090280]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of T cell apoptotic process [GO:0070232]; regulation of T cell proliferation [GO:0042129]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Nucleus. Secreted {ECO:0000269|PubMed:32272059}. Note=Secreted by a non-classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). {ECO:0000269|PubMed:32272059}.
P17936	reviewed	IBP3_HUMAN	Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)	IGFBP3 IBP3	Homo sapiens (Human)	291	FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). {ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:20353938}.		apoptotic process [GO:0006915]; MAPK cascade [GO:0000165]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of signal transduction [GO:0009968]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; osteoblast differentiation [GO:0001649]; positive regulation of apoptotic process [GO:0043065]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast differentiation [GO:0045663]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of glucose metabolic process [GO:0010906]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; type B pancreatic cell proliferation [GO:0044342]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binding protein complex [GO:0016942]; insulin-like growth factor ternary complex [GO:0042567]; nucleus [GO:0005634]	fibronectin binding [GO:0001968]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activator activity [GO:0008160]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binding protein complex [GO:0016942]; insulin-like growth factor ternary complex [GO:0042567]; nucleus [GO:0005634]; fibronectin binding [GO:0001968]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activator activity [GO:0008160]; apoptotic process [GO:0006915]; MAPK cascade [GO:0000165]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of signal transduction [GO:0009968]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; osteoblast differentiation [GO:0001649]; positive regulation of apoptotic process [GO:0043065]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast differentiation [GO:0045663]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of glucose metabolic process [GO:0010906]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20353938}.
P17947	reviewed	SPI1_HUMAN	Transcription factor PU.1 (31 kDa-transforming protein)	SPI1	Homo sapiens (Human)	270	FUNCTION: Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:33951726). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P17433, ECO:0000250|UniProtKB:Q6BDS1, ECO:0000269|PubMed:23658224, ECO:0000269|PubMed:33951726}.		anatomical structure regression [GO:0060033]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; defense response to tumor cell [GO:0002357]; endothelial to hematopoietic transition [GO:0098508]; erythrocyte differentiation [GO:0030218]; follicular B cell differentiation [GO:0002316]; germinal center B cell differentiation [GO:0002314]; granulocyte differentiation [GO:0030851]; immature B cell differentiation [GO:0002327]; interleukin-6-mediated signaling pathway [GO:0070102]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage differentiation [GO:0030225]; myeloid dendritic cell differentiation [GO:0043011]; myeloid leukocyte differentiation [GO:0002573]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of neutrophil degranulation [GO:0043314]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oncogene-induced cell senescence [GO:0090402]; pericyte cell differentiation [GO:1904238]; positive regulation of antifungal innate immune response [GO:1905036]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of myeloid dendritic cell chemotaxis [GO:2000529]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pro-T cell differentiation [GO:0002572]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of DNA-templated transcription [GO:0006355]; regulation of erythrocyte differentiation [GO:0045646]; regulation of myeloid progenitor cell differentiation [GO:1905453]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; TRAIL-activated apoptotic signaling pathway [GO:0036462]; transcription initiation-coupled chromatin remodeling [GO:0045815]; transforming growth factor beta receptor signaling pathway [GO:0007179]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; molecular adaptor activity [GO:0060090]; NFAT protein binding [GO:0051525]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; molecular adaptor activity [GO:0060090]; NFAT protein binding [GO:0051525]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure regression [GO:0060033]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; defense response to tumor cell [GO:0002357]; endothelial to hematopoietic transition [GO:0098508]; erythrocyte differentiation [GO:0030218]; follicular B cell differentiation [GO:0002316]; germinal center B cell differentiation [GO:0002314]; granulocyte differentiation [GO:0030851]; immature B cell differentiation [GO:0002327]; interleukin-6-mediated signaling pathway [GO:0070102]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage differentiation [GO:0030225]; myeloid dendritic cell differentiation [GO:0043011]; myeloid leukocyte differentiation [GO:0002573]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of neutrophil degranulation [GO:0043314]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oncogene-induced cell senescence [GO:0090402]; pericyte cell differentiation [GO:1904238]; positive regulation of antifungal innate immune response [GO:1905036]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of myeloid dendritic cell chemotaxis [GO:2000529]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pro-T cell differentiation [GO:0002572]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of DNA-templated transcription [GO:0006355]; regulation of erythrocyte differentiation [GO:0045646]; regulation of myeloid progenitor cell differentiation [GO:1905453]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; TRAIL-activated apoptotic signaling pathway [GO:0036462]; transcription initiation-coupled chromatin remodeling [GO:0045815]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:33951726}.
P17948	reviewed	VGFR1_HUMAN	Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)	FLT1 FLT FRT VEGFR1	Homo sapiens (Human)	1338	FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}.		angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; embryonic morphogenesis [GO:0048598]; hyaloid vascular plexus regression [GO:1990384]; monocyte chemotaxis [GO:0002548]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C activity [GO:0010863]; protein autophosphorylation [GO:0046777]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-1 signaling pathway [GO:0036323]	actin cytoskeleton [GO:0015629]; endosome [GO:0005768]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; growth factor binding [GO:0019838]; placental growth factor receptor activity [GO:0036332]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; vascular endothelial growth factor receptor activity [GO:0005021]	actin cytoskeleton [GO:0015629]; endosome [GO:0005768]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; placental growth factor receptor activity [GO:0036332]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; vascular endothelial growth factor receptor activity [GO:0005021]; angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; embryonic morphogenesis [GO:0048598]; hyaloid vascular plexus regression [GO:1990384]; monocyte chemotaxis [GO:0002548]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C activity [GO:0010863]; protein autophosphorylation [GO:0046777]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-1 signaling pathway [GO:0036323]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Endosome. Note=Autophosphorylation promotes ubiquitination and endocytosis.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:8248162}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm {ECO:0000305}.
P17980	reviewed	PRS6A_HUMAN	26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)	PSMC3 TBP1	Homo sapiens (Human)	439	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.		modulation by host of viral transcription [GO:0043921]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; secretory granule lumen [GO:0034774]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; proteasome-activating activity [GO:0036402]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; secretory granule lumen [GO:0034774]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; proteasome-activating activity [GO:0036402]; modulation by host of viral transcription [GO:0043921]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250|UniProtKB:O88685}.
P17987	reviewed	TCPA_HUMAN	T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha)	TCP1 CCT1 CCTA	Homo sapiens (Human)	556	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.		binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666]; tubulin complex assembly [GO:0007021]	acrosomal vesicle [GO:0001669]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; heterochromatin [GO:0000792]; microtubule [GO:0005874]; pericentriolar material [GO:0000242]; zona pellucida receptor complex [GO:0002199]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	acrosomal vesicle [GO:0001669]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; heterochromatin [GO:0000792]; microtubule [GO:0005874]; pericentriolar material [GO:0000242]; zona pellucida receptor complex [GO:0002199]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666]; tubulin complex assembly [GO:0007021]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1630492}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20080638}.
P18031	reviewed	PTN1_HUMAN	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)	PTPN1 PTP1B	Homo sapiens (Human)	435	FUNCTION: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.		actin cytoskeleton organization [GO:0030036]; cellular response to unfolded protein [GO:0034620]; endoplasmic reticulum unfolded protein response [GO:0030968]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; insulin receptor recycling [GO:0038020]; insulin receptor signaling pathway [GO:0008286]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of signal transduction [GO:0009968]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of receptor catabolic process [GO:2000646]; protein dephosphorylation [GO:0006470]; regulation of endocytosis [GO:0030100]; regulation of hepatocyte growth factor receptor signaling pathway [GO:1902202]; regulation of intracellular protein transport [GO:0033157]; regulation of signal transduction [GO:0009966]; regulation of type I interferon-mediated signaling pathway [GO:0060338]	cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endosome lumen [GO:0031904]; mitochondrial crista [GO:0030061]; mitochondrial matrix [GO:0005759]; protein-containing complex [GO:0032991]; sorting endosome [GO:0097443]	cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; insulin receptor binding [GO:0005158]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endosome lumen [GO:0031904]; mitochondrial crista [GO:0030061]; mitochondrial matrix [GO:0005759]; protein-containing complex [GO:0032991]; sorting endosome [GO:0097443]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; insulin receptor binding [GO:0005158]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; actin cytoskeleton organization [GO:0030036]; cellular response to unfolded protein [GO:0034620]; endoplasmic reticulum unfolded protein response [GO:0030968]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; insulin receptor recycling [GO:0038020]; insulin receptor signaling pathway [GO:0008286]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of signal transduction [GO:0009968]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of receptor catabolic process [GO:2000646]; protein dephosphorylation [GO:0006470]; regulation of endocytosis [GO:0030100]; regulation of hepatocyte growth factor receptor signaling pathway [GO:1902202]; regulation of intracellular protein transport [GO:0033157]; regulation of signal transduction [GO:0009966]; regulation of type I interferon-mediated signaling pathway [GO:0060338]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Peripheral membrane protein {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Cytoplasmic side {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}. Note=Interacts with EPHA3 at the cell membrane.
P18054	reviewed	LOX12_HUMAN	Polyunsaturated fatty acid lipoxygenase ALOX12 (EC 1.13.11.-) (Arachidonate (12S)-lipoxygenase) (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Arachidonate (15S)-lipoxygenase) (EC 1.13.11.33) (Linoleate (13S)-lipoxygenase) (Lipoxin synthase 12-LO) (EC 3.3.2.-) (Platelet-type lipoxygenase 12)	ALOX12 12LO LOG12	Homo sapiens (Human)	663	FUNCTION: Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:17493578, PubMed:1851637, PubMed:8319693, PubMed:8500694, PubMed:18311922, PubMed:32404334). Mainly converts arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to the specific bioactive lipid (12S)-hydroperoxyeicosatetraenoate/(12S)-HPETE (PubMed:17493578, PubMed:22984144, PubMed:24282679, PubMed:8319693, PubMed:8500694). Through the production of bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation (PubMed:8319693, PubMed:8500694). It can also catalyze the epoxidation of double bonds of polyunsaturated fatty acids such as (14S)-hydroperoxy-docosahexaenoate/(14S)-HPDHA resulting in the formation of (13S,14S)-epoxy-DHA (PubMed:23504711). Furthermore, it may participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). An additional function involves a multistep process by which it transforms leukotriene A4/LTA4 into the bioactive lipids lipoxin A4/LXA4 and lipoxin B4/LXB4, both are vasoactive and LXA4 may regulate neutrophil function via occupancy of specific recognition sites (PubMed:8250832). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to (13S)-hydroperoxyoctadecadienoate/ (13S-HPODE) (By similarity). Due to its role in regulating both the expression of the vascular endothelial growth factor (VEGF, an angiogenic factor involved in the survival and metastasis of solid tumors) and the expression of integrin beta-1 (known to affect tumor cell migration and proliferation), it can be regarded as protumorigenic (PubMed:9751607, PubMed:16638750, PubMed:22237009). Important for cell survival, as it may play a role not only in proliferation but also in the prevention of apoptosis in vascular smooth muscle cells (PubMed:23578768). {ECO:0000250|UniProtKB:P39655, ECO:0000269|PubMed:16638750, ECO:0000269|PubMed:17493578, ECO:0000269|PubMed:18311922, ECO:0000269|PubMed:1851637, ECO:0000269|PubMed:22237009, ECO:0000269|PubMed:22984144, ECO:0000269|PubMed:23504711, ECO:0000269|PubMed:23578768, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:32404334, ECO:0000269|PubMed:8250832, ECO:0000269|PubMed:8319693, ECO:0000269|PubMed:8500694, ECO:0000269|PubMed:9751607}.		arachidonic acid metabolic process [GO:0019369]; establishment of skin barrier [GO:0061436]; fatty acid oxidation [GO:0019395]; hepoxilin biosynthetic process [GO:0051122]; leukotriene A4 metabolic process [GO:1901751]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxin B4 biosynthetic process [GO:2001306]; lipoxygenase pathway [GO:0019372]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of platelet aggregation [GO:0090331]; superoxide anion generation [GO:0042554]; unsaturated fatty acid metabolic process [GO:0033559]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; sarcolemma [GO:0042383]	arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 15-lipoxygenase activity [GO:0050473]; hepoxilin-epoxide hydrolase activity [GO:0047977]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; sarcolemma [GO:0042383]; arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 15-lipoxygenase activity [GO:0050473]; hepoxilin-epoxide hydrolase activity [GO:0047977]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165]; arachidonic acid metabolic process [GO:0019369]; establishment of skin barrier [GO:0061436]; fatty acid oxidation [GO:0019395]; hepoxilin biosynthetic process [GO:0051122]; leukotriene A4 metabolic process [GO:1901751]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxin B4 biosynthetic process [GO:2001306]; lipoxygenase pathway [GO:0019372]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of platelet aggregation [GO:0090331]; superoxide anion generation [GO:0042554]; unsaturated fatty acid metabolic process [GO:0033559]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF.
P18065	reviewed	IBP2_HUMAN	Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2)	IGFBP2 BP2 IBP2	Homo sapiens (Human)	325	FUNCTION: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. {ECO:0000269|PubMed:19081843}.		cellular response to hormone stimulus [GO:0032870]; female pregnancy [GO:0007565]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of activated T cell proliferation [GO:0042104]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to mechanical stimulus [GO:0009612]; response to nutrient [GO:0007584]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102]; cellular response to hormone stimulus [GO:0032870]; female pregnancy [GO:0007565]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of activated T cell proliferation [GO:0042104]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to mechanical stimulus [GO:0009612]; response to nutrient [GO:0007584]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Secreted.
P18074	reviewed	ERCC2_HUMAN	General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 3.6.4.12) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein)	ERCC2 XPD XPDC	Homo sapiens (Human)	760	FUNCTION: ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:15494306, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:8413672}.		apoptotic process [GO:0006915]; bone mineralization [GO:0030282]; central nervous system myelin formation [GO:0032289]; chromosome segregation [GO:0007059]; determination of adult lifespan [GO:0008340]; embryonic cleavage [GO:0040016]; embryonic organ development [GO:0048568]; erythrocyte maturation [GO:0043249]; extracellular matrix organization [GO:0030198]; hair cell differentiation [GO:0035315]; hair follicle maturation [GO:0048820]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell proliferation [GO:0071425]; in utero embryonic development [GO:0001701]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; multicellular organism growth [GO:0035264]; nucleotide-excision repair [GO:0006289]; positive regulation of mitotic recombination [GO:0045951]; post-embryonic development [GO:0009791]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; spinal cord development [GO:0021510]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; transcription-coupled nucleotide-excision repair [GO:0006283]; UV protection [GO:0009650]	CAK-ERCC2 complex [GO:0070516]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]	4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; damaged DNA binding [GO:0003684]; DNA helicase activity [GO:0003678]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]	CAK-ERCC2 complex [GO:0070516]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; 4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; damaged DNA binding [GO:0003684]; DNA helicase activity [GO:0003678]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; apoptotic process [GO:0006915]; bone mineralization [GO:0030282]; central nervous system myelin formation [GO:0032289]; chromosome segregation [GO:0007059]; determination of adult lifespan [GO:0008340]; embryonic cleavage [GO:0040016]; embryonic organ development [GO:0048568]; erythrocyte maturation [GO:0043249]; extracellular matrix organization [GO:0030198]; hair cell differentiation [GO:0035315]; hair follicle maturation [GO:0048820]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell proliferation [GO:0071425]; in utero embryonic development [GO:0001701]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; multicellular organism growth [GO:0035264]; nucleotide-excision repair [GO:0006289]; positive regulation of mitotic recombination [GO:0045951]; post-embryonic development [GO:0009791]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; spinal cord development [GO:0021510]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; transcription-coupled nucleotide-excision repair [GO:0006283]; UV protection [GO:0009650]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:23585563}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20797633}.
P18075	reviewed	BMP7_HUMAN	Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)	BMP7 OP1	Homo sapiens (Human)	431	FUNCTION: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:9748228, PubMed:12667445). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509). {ECO:0000269|PubMed:12478285, ECO:0000269|PubMed:12667445, ECO:0000269|PubMed:27923061, ECO:0000269|PubMed:30097509, ECO:0000269|PubMed:31208997, ECO:0000269|PubMed:9748228}.		allantois development [GO:1905069]; ameloblast differentiation [GO:0036305]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; branching involved in salivary gland morphogenesis [GO:0060445]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac muscle tissue development [GO:0048738]; cardiac septum morphogenesis [GO:0060411]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; cellular response to hypoxia [GO:0071456]; chorio-allantoic fusion [GO:0060710]; dendrite development [GO:0016358]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic skeletal joint morphogenesis [GO:0060272]; endocardial cushion formation [GO:0003272]; epithelial to mesenchymal transition [GO:0001837]; heart trabecula morphogenesis [GO:0061384]; hindbrain development [GO:0030902]; mesenchymal cell apoptotic process involved in nephron morphogenesis [GO:1901145]; mesenchymal cell differentiation [GO:0048762]; mesenchyme development [GO:0060485]; mesoderm formation [GO:0001707]; mesonephros development [GO:0001823]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; metanephric mesenchyme morphogenesis [GO:0072133]; metanephros development [GO:0001656]; monocyte aggregation [GO:0070487]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glomerular mesangial cell proliferation [GO:0072125]; negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis [GO:0072040]; negative regulation of mitotic nuclear division [GO:0045839]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neural fold elevation formation [GO:0021502]; neuron projection morphogenesis [GO:0048812]; odontogenesis of dentin-containing tooth [GO:0042475]; ossification [GO:0001503]; pericardium morphogenesis [GO:0003344]; pharyngeal system development [GO:0060037]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of dendrite development [GO:1900006]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of hyaluranon cable assembly [GO:1900106]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of phosphorylation [GO:0042325]; regulation of removal of superoxide radicals [GO:2000121]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]; response to vitamin D [GO:0033280]; skeletal system development [GO:0001501]; ureteric bud development [GO:0001657]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; vesicle [GO:0031982]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; vesicle [GO:0031982]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; allantois development [GO:1905069]; ameloblast differentiation [GO:0036305]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; branching involved in salivary gland morphogenesis [GO:0060445]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac muscle tissue development [GO:0048738]; cardiac septum morphogenesis [GO:0060411]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; cellular response to hypoxia [GO:0071456]; chorio-allantoic fusion [GO:0060710]; dendrite development [GO:0016358]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic skeletal joint morphogenesis [GO:0060272]; endocardial cushion formation [GO:0003272]; epithelial to mesenchymal transition [GO:0001837]; heart trabecula morphogenesis [GO:0061384]; hindbrain development [GO:0030902]; mesenchymal cell apoptotic process involved in nephron morphogenesis [GO:1901145]; mesenchymal cell differentiation [GO:0048762]; mesenchyme development [GO:0060485]; mesoderm formation [GO:0001707]; mesonephros development [GO:0001823]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; metanephric mesenchyme morphogenesis [GO:0072133]; metanephros development [GO:0001656]; monocyte aggregation [GO:0070487]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glomerular mesangial cell proliferation [GO:0072125]; negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis [GO:0072040]; negative regulation of mitotic nuclear division [GO:0045839]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neural fold elevation formation [GO:0021502]; neuron projection morphogenesis [GO:0048812]; odontogenesis of dentin-containing tooth [GO:0042475]; ossification [GO:0001503]; pericardium morphogenesis [GO:0003344]; pharyngeal system development [GO:0060037]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of dendrite development [GO:1900006]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of hyaluranon cable assembly [GO:1900106]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of phosphorylation [GO:0042325]; regulation of removal of superoxide radicals [GO:2000121]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]; response to vitamin D [GO:0033280]; skeletal system development [GO:0001501]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Secreted.
P18077	reviewed	RL35A_HUMAN	Large ribosomal subunit protein eL33 (60S ribosomal protein L35a) (Cell growth-inhibiting gene 33 protein)	RPL35A GIG33	Homo sapiens (Human)	110	FUNCTION: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Required for the proliferation and viability of hematopoietic cells (PubMed:18535205). {ECO:0000269|PubMed:18535205, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.	MISCELLANEOUS: Knockdown of RPL35A in hematopoietic cell lines results in decreased cell proliferation, increased apoptosis, decreased biogenesis of mature 60S ribosomal subunit, and abnormal processing of large ribosomal subunit rRNA. {ECO:0000269|PubMed:18535205}.	cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P18084	reviewed	ITB5_HUMAN	Integrin beta-5	ITGB5	Homo sapiens (Human)	799	FUNCTION: Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:20615244}.		cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; epithelial cell-cell adhesion [GO:0090136]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alphav-beta5 complex [GO:0034684]; integrin complex [GO:0008305]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	integrin binding [GO:0005178]; metal ion binding [GO:0046872]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alphav-beta5 complex [GO:0034684]; integrin complex [GO:0008305]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; virus receptor activity [GO:0001618]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; epithelial cell-cell adhesion [GO:0090136]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P18085	reviewed	ARF4_HUMAN	ADP-ribosylation factor 4	ARF4 ARF2	Homo sapiens (Human)	180	FUNCTION: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000269|PubMed:25673879}.		activation of phospholipase D activity [GO:0031584]; apical protein localization [GO:0045176]; cell migration [GO:0016477]; cilium assembly [GO:0060271]; dendritic spine development [GO:0060996]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular protein transport [GO:0006886]; learning [GO:0007612]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cilium [GO:0061512]; regulation of cilium assembly [GO:1902017]; regulation of postsynapse organization [GO:0099175]; regulation of reactive oxygen species metabolic process [GO:2000377]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	epidermal growth factor receptor binding [GO:0005154]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]	cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; epidermal growth factor receptor binding [GO:0005154]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; activation of phospholipase D activity [GO:0031584]; apical protein localization [GO:0045176]; cell migration [GO:0016477]; cilium assembly [GO:0060271]; dendritic spine development [GO:0060996]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular protein transport [GO:0006886]; learning [GO:0007612]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cilium [GO:0061512]; regulation of cilium assembly [GO:1902017]; regulation of postsynapse organization [GO:0099175]; regulation of reactive oxygen species metabolic process [GO:2000377]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:25673879}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
P18089	reviewed	ADA2B_HUMAN	Alpha-2B adrenergic receptor (Alpha-2 adrenergic receptor subtype C2) (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR)	ADRA2B ADRA2L1 ADRA2RL1	Homo sapiens (Human)	450	FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. {ECO:0000269|PubMed:23105096}.		activation of protein kinase B activity [GO:0032148]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adrenergic receptor signaling pathway [GO:0071875]; angiogenesis [GO:0001525]; cell-cell signaling [GO:0007267]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; MAPK cascade [GO:0000165]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of norepinephrine secretion [GO:0010700]; platelet activation [GO:0030168]; positive regulation of blood pressure [GO:0045777]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of uterine smooth muscle contraction [GO:0070474]; receptor transactivation [GO:0035624]; regulation of vascular associated smooth muscle contraction [GO:0003056]	cell surface [GO:0009986]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	alpha2-adrenergic receptor activity [GO:0004938]; epinephrine binding [GO:0051379]	cell surface [GO:0009986]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; alpha2-adrenergic receptor activity [GO:0004938]; epinephrine binding [GO:0051379]; activation of protein kinase B activity [GO:0032148]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adrenergic receptor signaling pathway [GO:0071875]; angiogenesis [GO:0001525]; cell-cell signaling [GO:0007267]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; MAPK cascade [GO:0000165]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of norepinephrine secretion [GO:0010700]; platelet activation [GO:0030168]; positive regulation of blood pressure [GO:0045777]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of uterine smooth muscle contraction [GO:0070474]; receptor transactivation [GO:0035624]; regulation of vascular associated smooth muscle contraction [GO:0003056]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23105096, ECO:0000269|PubMed:26811329, ECO:0000269|PubMed:27901063}; Multi-pass membrane protein {ECO:0000269|PubMed:23105096}. Note=Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. {ECO:0000269|PubMed:23105096, ECO:0000269|PubMed:26811329, ECO:0000269|PubMed:27901063}.
P18124	reviewed	RL7_HUMAN	Large ribosomal subunit protein uL30 (60S ribosomal protein L7)	RPL7	Homo sapiens (Human)	248	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). Binds to G-rich structures in 28S rRNA and in mRNAs (PubMed:12962325). Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (PubMed:12962325). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P18146	reviewed	EGR1_HUMAN	Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24)	EGR1 KROX24 ZNF225	Homo sapiens (Human)	543	FUNCTION: Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). {ECO:0000250|UniProtKB:P08046, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311}.		BMP signaling pathway [GO:0030509]; cellular response to gamma radiation [GO:0071480]; cellular response to heparin [GO:0071504]; cellular response to interleukin-8 [GO:0098759]; cellular response to mycophenolic acid [GO:0071506]; circadian regulation of gene expression [GO:0032922]; circadian temperature homeostasis [GO:0060086]; estrous cycle [GO:0044849]; glomerular mesangial cell proliferation [GO:0072110]; interleukin-1-mediated signaling pathway [GO:0070498]; locomotor rhythm [GO:0045475]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chemokine production [GO:0032722]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular metanephric mesangial cell proliferation [GO:0072303]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of post-translational protein modification [GO:1901875]; positive regulation of tau-protein kinase activity [GO:1902949]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron apoptotic process [GO:0043523]; regulation of progesterone biosynthetic process [GO:2000182]; regulation of protein sumoylation [GO:0033233]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to ischemia [GO:0002931]; skeletal muscle cell differentiation [GO:0035914]; T cell differentiation [GO:0030217]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded methylated DNA binding [GO:0010385]; hemi-methylated DNA-binding [GO:0044729]; histone acetyltransferase binding [GO:0035035]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded methylated DNA binding [GO:0010385]; hemi-methylated DNA-binding [GO:0044729]; histone acetyltransferase binding [GO:0035035]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; BMP signaling pathway [GO:0030509]; cellular response to gamma radiation [GO:0071480]; cellular response to heparin [GO:0071504]; cellular response to interleukin-8 [GO:0098759]; cellular response to mycophenolic acid [GO:0071506]; circadian regulation of gene expression [GO:0032922]; circadian temperature homeostasis [GO:0060086]; estrous cycle [GO:0044849]; glomerular mesangial cell proliferation [GO:0072110]; interleukin-1-mediated signaling pathway [GO:0070498]; locomotor rhythm [GO:0045475]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chemokine production [GO:0032722]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular metanephric mesangial cell proliferation [GO:0072303]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of post-translational protein modification [GO:1901875]; positive regulation of tau-protein kinase activity [GO:1902949]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron apoptotic process [GO:0043523]; regulation of progesterone biosynthetic process [GO:2000182]; regulation of protein sumoylation [GO:0033233]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to ischemia [GO:0002931]; skeletal muscle cell differentiation [GO:0035914]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20363028}. Cytoplasm {ECO:0000269|PubMed:20363028}.
P18206	reviewed	VINC_HUMAN	Vinculin (Metavinculin) (MV)	VCL	Homo sapiens (Human)	1134	FUNCTION: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}.		adherens junction assembly [GO:0034333]; apical junction assembly [GO:0043297]; axon extension [GO:0048675]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; epithelial cell-cell adhesion [GO:0090136]; lamellipodium assembly [GO:0030032]; maintenance of blood-brain barrier [GO:0035633]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cell migration [GO:0030336]; platelet aggregation [GO:0070527]; protein localization to cell surface [GO:0034394]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of protein localization to adherens junction [GO:1904702]	adherens junction [GO:0005912]; brush border [GO:0005903]; cell projection [GO:0042995]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; fascia adherens [GO:0005916]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; inner dense plaque of desmosome [GO:0090637]; membrane raft [GO:0045121]; outer dense plaque of desmosome [GO:0090636]; plasma membrane [GO:0005886]; podosome ring [GO:0061826]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; terminal web [GO:1990357]; zonula adherens [GO:0005915]	actin binding [GO:0003779]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; dystroglycan binding [GO:0002162]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625]	adherens junction [GO:0005912]; brush border [GO:0005903]; cell projection [GO:0042995]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; fascia adherens [GO:0005916]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; inner dense plaque of desmosome [GO:0090637]; membrane raft [GO:0045121]; outer dense plaque of desmosome [GO:0090636]; plasma membrane [GO:0005886]; podosome ring [GO:0061826]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; terminal web [GO:1990357]; zonula adherens [GO:0005915]; actin binding [GO:0003779]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; dystroglycan binding [GO:0002162]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625]; adherens junction assembly [GO:0034333]; apical junction assembly [GO:0043297]; axon extension [GO:0048675]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; epithelial cell-cell adhesion [GO:0090136]; lamellipodium assembly [GO:0030032]; maintenance of blood-brain barrier [GO:0035633]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cell migration [GO:0030336]; platelet aggregation [GO:0070527]; protein localization to cell surface [GO:0034394]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of protein localization to adherens junction [GO:1904702]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P12003}; Peripheral membrane protein {ECO:0000250|UniProtKB:P12003}; Cytoplasmic side {ECO:0000250|UniProtKB:P12003}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P12003}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P12003}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P85972}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q64727}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64727}; Cytoplasmic side {ECO:0000250|UniProtKB:Q64727}. Cell projection, podosome {ECO:0000250|UniProtKB:Q64727}. Note=Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions. {ECO:0000250|UniProtKB:P12003}.
P18283	reviewed	GPX2_HUMAN	Glutathione peroxidase 2 (GPx-2) (GSHPx-2) (EC 1.11.1.9) (Gastrointestinal glutathione peroxidase) (Glutathione peroxidase-gastrointestinal) (GPx-GI) (GSHPx-GI) (Glutathione peroxidase-related protein 2) (GPRP-2)	GPX2	Homo sapiens (Human)	190	FUNCTION: Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides (PubMed:8428933). Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors (PubMed:8428933). {ECO:0000269|PubMed:8428933}.		response to oxidative stress [GO:0006979]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]	electron transfer activity [GO:0009055]; glutathione peroxidase activity [GO:0004602]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; electron transfer activity [GO:0009055]; glutathione peroxidase activity [GO:0004602]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:8428933}.
P18405	reviewed	S5A1_HUMAN	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.22) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1)	SRD5A1	Homo sapiens (Human)	259	FUNCTION: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. {ECO:0000269|PubMed:2339109}.		androgen biosynthetic process [GO:0006702]; androgen catabolic process [GO:0006710]; bone development [GO:0060348]; cell differentiation [GO:0030154]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to estradiol stimulus [GO:0071392]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; cellular response to starvation [GO:0009267]; cellular response to testosterone stimulus [GO:0071394]; cerebral cortex development [GO:0021987]; diterpenoid metabolic process [GO:0016101]; female genitalia development [GO:0030540]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; liver development [GO:0001889]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; pituitary gland development [GO:0021983]; progesterone metabolic process [GO:0042448]; response to estrogen [GO:0043627]; response to follicle-stimulating hormone [GO:0032354]; response to fungicide [GO:0060992]; response to growth hormone [GO:0060416]; response to muscle activity [GO:0014850]; response to xenobiotic stimulus [GO:0009410]; serotonin metabolic process [GO:0042428]; sex determination [GO:0007530]; spinal cord development [GO:0021510]; steroid biosynthetic process [GO:0006694]; thalamus development [GO:0021794]; urogenital system development [GO:0001655]	cell body fiber [GO:0070852]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]	3-oxo-5-alpha-steroid 4-dehydrogenase activity [GO:0003865]; 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) [GO:0047751]; amide binding [GO:0033218]; electron transfer activity [GO:0009055]; NADPH binding [GO:0070402]	cell body fiber [GO:0070852]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; 3-oxo-5-alpha-steroid 4-dehydrogenase activity [GO:0003865]; 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) [GO:0047751]; amide binding [GO:0033218]; electron transfer activity [GO:0009055]; NADPH binding [GO:0070402]; androgen biosynthetic process [GO:0006702]; androgen catabolic process [GO:0006710]; bone development [GO:0060348]; cell differentiation [GO:0030154]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to estradiol stimulus [GO:0071392]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; cellular response to starvation [GO:0009267]; cellular response to testosterone stimulus [GO:0071394]; cerebral cortex development [GO:0021987]; diterpenoid metabolic process [GO:0016101]; female genitalia development [GO:0030540]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; liver development [GO:0001889]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; pituitary gland development [GO:0021983]; progesterone metabolic process [GO:0042448]; response to estrogen [GO:0043627]; response to follicle-stimulating hormone [GO:0032354]; response to fungicide [GO:0060992]; response to growth hormone [GO:0060416]; response to muscle activity [GO:0014850]; response to xenobiotic stimulus [GO:0009410]; serotonin metabolic process [GO:0042428]; sex determination [GO:0007530]; spinal cord development [GO:0021510]; steroid biosynthetic process [GO:0006694]; thalamus development [GO:0021794]; urogenital system development [GO:0001655]	SUBCELLULAR LOCATION: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P18428	reviewed	LBP_HUMAN	Lipopolysaccharide-binding protein (LBP)	LBP	Homo sapiens (Human)	481	FUNCTION: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359). {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:20133493, ECO:0000269|PubMed:24120359, ECO:0000269|PubMed:7517398, ECO:0000305|PubMed:17481951}.		acute-phase response [GO:0006953]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of molecule of bacterial origin [GO:0032490]; innate immune response [GO:0045087]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; lipopolysaccharide transport [GO:0015920]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; negative regulation of tumor necrosis factor production [GO:0032720]; neutrophil chemotaxis [GO:0030593]; opsonization [GO:0008228]; positive regulation of chemokine production [GO:0032722]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage activation [GO:0043032]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of respiratory burst involved in inflammatory response [GO:0060265]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor production [GO:0032760]; response to lipopolysaccharide [GO:0032496]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]	coreceptor activity [GO:0015026]; lipopeptide binding [GO:0071723]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; coreceptor activity [GO:0015026]; lipopeptide binding [GO:0071723]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; signaling receptor binding [GO:0005102]; acute-phase response [GO:0006953]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of molecule of bacterial origin [GO:0032490]; innate immune response [GO:0045087]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; lipopolysaccharide transport [GO:0015920]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; negative regulation of tumor necrosis factor production [GO:0032720]; neutrophil chemotaxis [GO:0030593]; opsonization [GO:0008228]; positive regulation of chemokine production [GO:0032722]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage activation [GO:0043032]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of respiratory burst involved in inflammatory response [GO:0060265]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor production [GO:0032760]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2402637, ECO:0000269|PubMed:24120359, ECO:0000269|PubMed:7517398}. Cytoplasmic granule membrane {ECO:0000250|UniProtKB:P17213}. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000250|UniProtKB:P17213}.
P18433	reviewed	PTPRA_HUMAN	Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)	PTPRA PTPA PTPRL2	Homo sapiens (Human)	802	FUNCTION: Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity). {ECO:0000250|UniProtKB:P18052}.		dephosphorylation [GO:0016311]; insulin receptor signaling pathway [GO:0008286]; integrin-mediated signaling pathway [GO:0007229]; modulation of chemical synaptic transmission [GO:0050804]; regulation of focal adhesion assembly [GO:0051893]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]	protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; dephosphorylation [GO:0016311]; insulin receptor signaling pathway [GO:0008286]; integrin-mediated signaling pathway [GO:0007229]; modulation of chemical synaptic transmission [GO:0050804]; regulation of focal adhesion assembly [GO:0051893]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P18052}. Note=Localizes to focal adhesion sites following integrin engagement. {ECO:0000250|UniProtKB:P18052}.
P18440	reviewed	ARY1_HUMAN	Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N-acetyltransferase type 1) (NAT-1)	NAT1 AAC1	Homo sapiens (Human)	290	FUNCTION: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.	MISCELLANEOUS: NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme.	xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]	arylamine N-acetyltransferase activity [GO:0004060]	cytosol [GO:0005829]; arylamine N-acetyltransferase activity [GO:0004060]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm.
P18505	reviewed	GBRB1_HUMAN	Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1)	GABRB1	Homo sapiens (Human)	474	FUNCTION: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. {ECO:0000269|PubMed:26950270}.		cellular response to histamine [GO:0071420]; central nervous system neuron development [GO:0021954]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; monoatomic ion transport [GO:0006811]; ovulation cycle [GO:0042698]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; signal transduction [GO:0007165]	chloride channel complex [GO:0034707]; dendrite [GO:0030425]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]	G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential [GO:0150047]; GABA receptor binding [GO:0050811]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; ligand-gated monoatomic ion channel activity [GO:0015276]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	chloride channel complex [GO:0034707]; dendrite [GO:0030425]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential [GO:0150047]; GABA receptor binding [GO:0050811]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; ligand-gated monoatomic ion channel activity [GO:0015276]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; cellular response to histamine [GO:0071420]; central nervous system neuron development [GO:0021954]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; monoatomic ion transport [GO:0006811]; ovulation cycle [GO:0042698]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P50571}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P50571}. Cell membrane {ECO:0000269|PubMed:26950270}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P50571}.
P18507	reviewed	GBRG2_HUMAN	Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2)	GABRG2	Homo sapiens (Human)	475	FUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2538761, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750, PubMed:27864268). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). {ECO:0000250|UniProtKB:P22723, ECO:0000269|PubMed:23909897, ECO:0000269|PubMed:2538761, ECO:0000269|PubMed:25489750, ECO:0000269|PubMed:27864268, ECO:0000269|PubMed:29950725}.	MISCELLANEOUS: This subunit carries the benzodiazepine binding site.	adult behavior [GO:0030534]; cellular response to histamine [GO:0071420]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; post-embryonic development [GO:0009791]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	axon [GO:0030424]; chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	benzodiazepine receptor activity [GO:0008503]; chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	axon [GO:0030424]; chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; benzodiazepine receptor activity [GO:0008503]; chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; adult behavior [GO:0030534]; cellular response to histamine [GO:0071420]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; post-embryonic development [GO:0009791]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:2538761}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:2538761, ECO:0000269|PubMed:27864268}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:P22723}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P18508}.
P18509	reviewed	PACA_HUMAN	Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)]	ADCYAP1	Homo sapiens (Human)	176	FUNCTION: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). {ECO:0000250|UniProtKB:O70176, ECO:0000250|UniProtKB:P13589, ECO:0000269|PubMed:11175907, ECO:0000269|PubMed:23800469}.		activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP-mediated signaling [GO:0019933]; cell-cell signaling [GO:0007267]; female pregnancy [GO:0007565]; insulin secretion [GO:0030073]; negative regulation of cell cycle [GO:0045786]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of protein localization [GO:0032880]	extracellular region [GO:0005576]; neuron projection [GO:0043005]; perikaryon [GO:0043204]	neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428]; pituitary adenylate cyclase activating polypeptide activity [GO:0016521]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428]; pituitary adenylate cyclase activating polypeptide activity [GO:0016521]; signaling receptor binding [GO:0005102]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP-mediated signaling [GO:0019933]; cell-cell signaling [GO:0007267]; female pregnancy [GO:0007565]; insulin secretion [GO:0030073]; negative regulation of cell cycle [GO:0045786]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Secreted.
P18510	reviewed	IL1RA_HUMAN	Interleukin-1 receptor antagonist protein (IL-1RN) (IL-1ra) (IRAP) (ICIL-1RA) (IL1 inhibitor) (Anakinra)	IL1RN IL1F3 IL1RA	Homo sapiens (Human)	177	FUNCTION: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. {ECO:0000250|UniProtKB:P25085, ECO:0000269|PubMed:7775431}.		acute-phase response [GO:0006953]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; insulin secretion [GO:0030073]; lipid metabolic process [GO:0006629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; response to glucocorticoid [GO:0051384]	centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; interleukin-1 receptor antagonist activity [GO:0005152]; interleukin-1 receptor binding [GO:0005149]; interleukin-1 type I receptor antagonist activity [GO:0045352]; interleukin-1 type II receptor antagonist activity [GO:0045353]; interleukin-1, type I receptor binding [GO:0005150]; interleukin-1, type II receptor binding [GO:0005151]	centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; interleukin-1 receptor antagonist activity [GO:0005152]; interleukin-1 receptor binding [GO:0005149]; interleukin-1 type I receptor antagonist activity [GO:0045352]; interleukin-1 type II receptor antagonist activity [GO:0045353]; interleukin-1, type I receptor binding [GO:0005150]; interleukin-1, type II receptor binding [GO:0005151]; acute-phase response [GO:0006953]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; insulin secretion [GO:0030073]; lipid metabolic process [GO:0006629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; response to glucocorticoid [GO:0051384]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000269|PubMed:32384874}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
P18545	reviewed	CNRG_HUMAN	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (GMP-PDE gamma) (EC 3.1.4.35)	PDE6G PDEG	Homo sapiens (Human)	87	FUNCTION: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.		positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of MAPK cascade [GO:0043410]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]	3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cGMP binding [GO:0030553]; enzyme inhibitor activity [GO:0004857]; spectrin binding [GO:0030507]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cGMP binding [GO:0030553]; enzyme inhibitor activity [GO:0004857]; spectrin binding [GO:0030507]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of MAPK cascade [GO:0043410]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	
P18564	reviewed	ITB6_HUMAN	Integrin beta-6	ITGB6	Homo sapiens (Human)	788	FUNCTION: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881). It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881). Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:25383667, ECO:0000269|PubMed:28117447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260). {ECO:0000269|PubMed:24367260}.		bone development [GO:0060348]; bronchiole development [GO:0060435]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell morphogenesis [GO:0000902]; cell-matrix adhesion [GO:0007160]; cellular response to ionizing radiation [GO:0071479]; enamel mineralization [GO:0070166]; hard palate development [GO:0060022]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; Langerhans cell differentiation [GO:0061520]; lung alveolus development [GO:0048286]; phospholipid homeostasis [GO:0055091]; regulation of transforming growth factor beta activation [GO:1901388]; response to virus [GO:0009615]; skin development [GO:0043588]; SMAD protein signal transduction [GO:0060395]; surfactant homeostasis [GO:0043129]; transforming growth factor beta production [GO:0071604]; transforming growth factor beta receptor signaling pathway [GO:0007179]; wound healing [GO:0042060]	cell junction [GO:0030054]; cell surface [GO:0009986]; centrosome [GO:0005813]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alphav-beta6 complex [GO:0034685]; integrin complex [GO:0008305]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	integrin binding [GO:0005178]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; virus receptor activity [GO:0001618]	cell junction [GO:0030054]; cell surface [GO:0009986]; centrosome [GO:0005813]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alphav-beta6 complex [GO:0034685]; integrin complex [GO:0008305]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; virus receptor activity [GO:0001618]; bone development [GO:0060348]; bronchiole development [GO:0060435]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell morphogenesis [GO:0000902]; cell-matrix adhesion [GO:0007160]; cellular response to ionizing radiation [GO:0071479]; enamel mineralization [GO:0070166]; hard palate development [GO:0060022]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; Langerhans cell differentiation [GO:0061520]; lung alveolus development [GO:0048286]; phospholipid homeostasis [GO:0055091]; regulation of transforming growth factor beta activation [GO:1901388]; response to virus [GO:0009615]; skin development [GO:0043588]; SMAD protein signal transduction [GO:0060395]; surfactant homeostasis [GO:0043129]; transforming growth factor beta production [GO:0071604]; transforming growth factor beta receptor signaling pathway [GO:0007179]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17545607}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}.
P18577	reviewed	RHCE_HUMAN	Blood group Rh(CE) polypeptide (Rh polypeptide 1) (RhPI) (Rh30A) (RhIXB) (Rhesus C/E antigens) (CD antigen CD240CE)	RHCE RHC RHE	Homo sapiens (Human)	417	FUNCTION: Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Mediates the primary membrane attachment site for ANK1 when associated with RHAG (PubMed:35835865). May participate in the ammonium and carbon dioxide transport through the heterotrimer form (Probable). {ECO:0000269|PubMed:35835865, ECO:0000305}.		ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]	ankyrin-1 complex [GO:0170014]; plasma membrane [GO:0005886]	ammonium transmembrane transporter activity [GO:0008519]	ankyrin-1 complex [GO:0170014]; plasma membrane [GO:0005886]; ammonium transmembrane transporter activity [GO:0008519]; ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P18583	reviewed	SON_HUMAN	Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3)	SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312	Homo sapiens (Human)	2426	FUNCTION: RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}.	MISCELLANEOUS: [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform E]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; regulation of cell cycle [GO:0051726]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]	DNA binding [GO:0003677]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; regulation of cell cycle [GO:0051726]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:1424986, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:34023904}. Note=Colocalizes with the pre-mRNA splicing factor SRSF2.
P18615	reviewed	NELFE_HUMAN	Negative elongation factor E (NELF-E) (RNA-binding protein RD)	NELFE RD RDBP	Homo sapiens (Human)	380	FUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27282391, PubMed:27256882). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}.		localization [GO:0051179]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; NELF complex [GO:0032021]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	chromatin binding [GO:0003682]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	chromatin [GO:0000785]; NELF complex [GO:0032021]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; chromatin binding [GO:0003682]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; localization [GO:0051179]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14701750}. Chromosome {ECO:0000269|PubMed:14701750}. Note=Localizes to chromatin (PubMed:14701750). Phosphorylation by the P-TEFb complex promotes its release from chromatin (PubMed:14701750). {ECO:0000269|PubMed:14701750}.
P18621	reviewed	RL17_HUMAN	Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (60S ribosomal protein L23) (PD-1)	RPL17	Homo sapiens (Human)	184	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P18627	reviewed	LAG3_HUMAN	Lymphocyte activation gene 3 protein (LAG-3) (CD antigen CD223) [Cleaved into: Secreted lymphocyte activation gene 3 protein (sLAG-3)]	LAG3 FDC	Homo sapiens (Human)	525	FUNCTION: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185). {ECO:0000250|UniProtKB:Q61790, ECO:0000269|PubMed:20421648, ECO:0000269|PubMed:7805750, ECO:0000269|PubMed:8647185}.; FUNCTION: [Secreted lymphocyte activation gene 3 protein]: May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response. {ECO:0000250|UniProtKB:Q61790}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of regulatory T cell differentiation [GO:0045590]; plasmacytoid dendritic cell activation [GO:0002270]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of immune response [GO:0050776]; T cell activation [GO:0042110]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]; MHC class II protein binding [GO:0042289]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; MHC class II protein binding [GO:0042289]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of regulatory T cell differentiation [GO:0045590]; plasmacytoid dendritic cell activation [GO:0002270]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of immune response [GO:0050776]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: [Lymphocyte activation gene 3 protein]: Cell membrane {ECO:0000269|PubMed:1380059, ECO:0000269|PubMed:1692078, ECO:0000269|PubMed:9634475}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Secreted lymphocyte activation gene 3 protein]: Secreted {ECO:0000250|UniProtKB:Q61790}. Note=Produced following cleavage of the main chain. {ECO:0000250|UniProtKB:Q61790}.
P18669	reviewed	PGAM1_HUMAN	Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B)	PGAM1 PGAMA CDABP0006	Homo sapiens (Human)	254	FUNCTION: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202). {ECO:0000269|PubMed:23653202}.		canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; regulation of glycolytic process [GO:0006110]; regulation of pentose-phosphate shunt [GO:0043456]; respiratory burst [GO:0045730]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]; phosphoglycerate mutase activity [GO:0004619]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]; phosphoglycerate mutase activity [GO:0004619]; protein kinase binding [GO:0019901]; canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; regulation of glycolytic process [GO:0006110]; regulation of pentose-phosphate shunt [GO:0043456]; respiratory burst [GO:0045730]	
P18754	reviewed	RCC1_HUMAN	Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)	RCC1 CHC1	Homo sapiens (Human)	421	FUNCTION: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:1944575, PubMed:17435751, PubMed:20668449, PubMed:22215983, PubMed:11336674). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:3678831}.	MISCELLANEOUS: Patients with Raynaud disease produce antibodies that bind to RCC1.	cell division [GO:0051301]; chromosome segregation [GO:0007059]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic nuclear membrane reassembly [GO:0007084]; mitotic spindle organization [GO:0007052]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly [GO:0051225]; viral process [GO:0016032]	chromatin [GO:0000785]; chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; guanyl-nucleotide exchange factor activity [GO:0005085]; histone binding [GO:0042393]; nucleosomal DNA binding [GO:0031492]; nucleosome binding [GO:0031491]; protein heterodimerization activity [GO:0046982]; small GTPase binding [GO:0031267]; sulfate binding [GO:0043199]	chromatin [GO:0000785]; chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; guanyl-nucleotide exchange factor activity [GO:0005085]; histone binding [GO:0042393]; nucleosomal DNA binding [GO:0031492]; nucleosome binding [GO:0031491]; protein heterodimerization activity [GO:0046982]; small GTPase binding [GO:0031267]; sulfate binding [GO:0043199]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic nuclear membrane reassembly [GO:0007084]; mitotic spindle organization [GO:0007052]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly [GO:0051225]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:16820410, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:2236072}. Chromosome {ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:20668449}. Cytoplasm {ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:20668449}. Note=Predominantly nuclear in interphase cells (PubMed:12194828). Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449). {ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:20668449}.
P18825	reviewed	ADA2C_HUMAN	Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR)	ADRA2C ADRA2L2 ADRA2RL2	Homo sapiens (Human)	462	FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.		activation of protein kinase B activity [GO:0032148]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adrenergic receptor signaling pathway [GO:0071875]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of norepinephrine secretion [GO:0010700]; platelet activation [GO:0030168]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron differentiation [GO:0045666]; receptor transactivation [GO:0035624]; regulation of smooth muscle contraction [GO:0006940]; regulation of vasoconstriction [GO:0019229]	cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886]	alpha-2A adrenergic receptor binding [GO:0031694]; alpha2-adrenergic receptor activity [GO:0004938]; epinephrine binding [GO:0051379]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886]; alpha-2A adrenergic receptor binding [GO:0031694]; alpha2-adrenergic receptor activity [GO:0004938]; epinephrine binding [GO:0051379]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; activation of protein kinase B activity [GO:0032148]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adrenergic receptor signaling pathway [GO:0071875]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of norepinephrine secretion [GO:0010700]; platelet activation [GO:0030168]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron differentiation [GO:0045666]; receptor transactivation [GO:0035624]; regulation of smooth muscle contraction [GO:0006940]; regulation of vasoconstriction [GO:0019229]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P18827	reviewed	SDC1_HUMAN	Syndecan-1 (SYND1) (CD antigen CD138)	SDC1 SDC	Homo sapiens (Human)	310	FUNCTION: Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). {ECO:0000250|UniProtKB:P18828, ECO:0000269|PubMed:22660413}.		canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; myoblast development [GO:0048627]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; receptor-mediated endocytosis [GO:0006898]; response to calcium ion [GO:0051592]; response to cAMP [GO:0051591]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to toxic substance [GO:0009636]; Sertoli cell development [GO:0060009]; striated muscle cell development [GO:0055002]; ureteric bud development [GO:0001657]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	cargo receptor activity [GO:0038024]; identical protein binding [GO:0042802]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; cargo receptor activity [GO:0038024]; identical protein binding [GO:0042802]; canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; myoblast development [GO:0048627]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; receptor-mediated endocytosis [GO:0006898]; response to calcium ion [GO:0051592]; response to cAMP [GO:0051591]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to toxic substance [GO:0009636]; Sertoli cell development [GO:0060009]; striated muscle cell development [GO:0055002]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:9169435}. Secreted, extracellular exosome {ECO:0000269|PubMed:22660413}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000269|PubMed:9169435}.
P18846	reviewed	ATF1_HUMAN	Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36)	ATF1	Homo sapiens (Human)	271	FUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}.		cAMP-mediated signaling [GO:0019933]; positive regulation of DNA replication [GO:0045740]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cobalt ion [GO:0032025]; response to purine-containing compound [GO:0014074]	ATF1-ATF4 transcription factor complex [GO:1990590]; ATF4-CREB1 transcription factor complex [GO:1990589]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	ATF1-ATF4 transcription factor complex [GO:1990590]; ATF4-CREB1 transcription factor complex [GO:1990589]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cAMP-mediated signaling [GO:0019933]; positive regulation of DNA replication [GO:0045740]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cobalt ion [GO:0032025]; response to purine-containing compound [GO:0014074]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29983246}.
P18847	reviewed	ATF3_HUMAN	Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)	ATF3	Homo sapiens (Human)	181	FUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. {ECO:0000269|PubMed:7515060}.; FUNCTION: [Isoform 2]: Activates transcription presumably by sequestering inhibitory cofactors away from the promoters. {ECO:0000269|PubMed:7515060}.; FUNCTION: [Isoform 3]: Stress-induced isoform, counteracts the transcriptional repression of isoform 1. {ECO:0000269|PubMed:12034827}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to amino acid starvation [GO:0034198]; endoplasmic reticulum unfolded protein response [GO:0030968]; gluconeogenesis [GO:0006094]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of TRAIL-activated apoptotic signaling pathway [GO:1903984]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]	CHOP-ATF3 complex [GO:1990622]; chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	CHOP-ATF3 complex [GO:1990622]; chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cellular response to amino acid starvation [GO:0034198]; endoplasmic reticulum unfolded protein response [GO:0030968]; gluconeogenesis [GO:0006094]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of TRAIL-activated apoptotic signaling pathway [GO:1903984]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12034827}.
P18848	reviewed	ATF4_HUMAN	Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67)	ATF4 CREB2 TXREB	Homo sapiens (Human)	351	FUNCTION: Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (PubMed:17684156, PubMed:16682973, PubMed:31444471, PubMed:32132707). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress (PubMed:32132707). During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (PubMed:32132706, PubMed:32132707). Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity). Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress (PubMed:26086088). Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress (PubMed:11960987). However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation (PubMed:18940792). Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (By similarity). Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress (PubMed:15775988). May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress (PubMed:33384352). In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (PubMed:15109498). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). Activates transcription of SIRT4 (By similarity). Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4 (By similarity). Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (By similarity). Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (By similarity). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471). {ECO:0000250|UniProtKB:Q06507, ECO:0000269|PubMed:11960987, ECO:0000269|PubMed:15109498, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17684156, ECO:0000269|PubMed:18940792, ECO:0000269|PubMed:26086088, ECO:0000269|PubMed:31444471, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:33384352}.; FUNCTION: (Microbial infection) Binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. {ECO:0000269|PubMed:1847461}.		bone mineralization [GO:0030282]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; cellular response to oxygen-glucose deprivation [GO:0090650]; cellular response to UV [GO:0034644]; circadian regulation of gene expression [GO:0032922]; embryonic hemopoiesis [GO:0035162]; endoplasmic reticulum unfolded protein response [GO:0030968]; gamma-aminobutyric acid signaling pathway [GO:0007214]; gluconeogenesis [GO:0006094]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; intracellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; L-asparagine metabolic process [GO:0070982]; lens fiber cell morphogenesis [GO:0070309]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translational initiation in response to stress [GO:0032057]; neuron differentiation [GO:0030182]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of apoptotic process [GO:0043065]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of sodium-dependent phosphate transport [GO:2000120]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0036091]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of DNA-templated transcription [GO:0006355]; regulation of osteoblast differentiation [GO:0045667]; regulation of synaptic plasticity [GO:0048167]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; response to nutrient levels [GO:0031667]; response to toxic substance [GO:0009636]; transcription by RNA polymerase II [GO:0006366]	ATF1-ATF4 transcription factor complex [GO:1990590]; ATF4-CREB1 transcription factor complex [GO:1990589]; CHOP-ATF4 complex [GO:1990617]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite membrane [GO:0032590]; Lewy body core [GO:1990037]; microtubule organizing center [GO:0005815]; neuron projection [GO:0043005]; nuclear periphery [GO:0034399]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]	cAMP response element binding protein binding [GO:0008140]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; general transcription initiation factor binding [GO:0140296]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	ATF1-ATF4 transcription factor complex [GO:1990590]; ATF4-CREB1 transcription factor complex [GO:1990589]; CHOP-ATF4 complex [GO:1990617]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite membrane [GO:0032590]; Lewy body core [GO:1990037]; microtubule organizing center [GO:0005815]; neuron projection [GO:0043005]; nuclear periphery [GO:0034399]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; cAMP response element binding protein binding [GO:0008140]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; general transcription initiation factor binding [GO:0140296]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; bone mineralization [GO:0030282]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; cellular response to oxygen-glucose deprivation [GO:0090650]; cellular response to UV [GO:0034644]; circadian regulation of gene expression [GO:0032922]; embryonic hemopoiesis [GO:0035162]; endoplasmic reticulum unfolded protein response [GO:0030968]; gamma-aminobutyric acid signaling pathway [GO:0007214]; gluconeogenesis [GO:0006094]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; intracellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; L-asparagine metabolic process [GO:0070982]; lens fiber cell morphogenesis [GO:0070309]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translational initiation in response to stress [GO:0032057]; neuron differentiation [GO:0030182]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of apoptotic process [GO:0043065]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of sodium-dependent phosphate transport [GO:2000120]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0036091]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of DNA-templated transcription [GO:0006355]; regulation of osteoblast differentiation [GO:0045667]; regulation of synaptic plasticity [GO:0048167]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; response to nutrient levels [GO:0031667]; response to toxic substance [GO:0009636]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:22974638, ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:31444471}. Nucleus speckle {ECO:0000269|PubMed:16219772}. Cytoplasm {ECO:0000250|UniProtKB:Q9ES19}. Cell membrane {ECO:0000250|UniProtKB:Q9ES19}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20873783}. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783). Recruited to nuclear speckles following interaction with EP300/p300 (PubMed:16219772). {ECO:0000250|UniProtKB:Q9ES19, ECO:0000269|PubMed:16219772, ECO:0000269|PubMed:20873783}.
P18850	reviewed	ATF6A_HUMAN	Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha]	ATF6	Homo sapiens (Human)	670	FUNCTION: [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed:10564271, PubMed:11163209, PubMed:11158310, PubMed:11779464). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed:10564271, PubMed:11158310, PubMed:11779464). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (PubMed:10564271, PubMed:11158310, PubMed:11779464). May play a role in foveal development and cone function in the retina (PubMed:26029869). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11163209, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:26029869}.		ATF6-mediated unfolded protein response [GO:0036500]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; eye development [GO:0001654]; positive regulation of apoptotic process [GO:0043065]; positive regulation of ATF6-mediated unfolded protein response [GO:1903893]; positive regulation of autophagy [GO:0010508]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; protein folding [GO:0006457]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; visual perception [GO:0007601]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ATF6-mediated unfolded protein response [GO:0036500]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; eye development [GO:0001654]; positive regulation of apoptotic process [GO:0043065]; positive regulation of ATF6-mediated unfolded protein response [GO:1903893]; positive regulation of autophagy [GO:0010508]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; protein folding [GO:0006457]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:12782636}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:12782636}; Single-pass type II membrane protein {ECO:0000255}. Note=Translocates from the endoplasmic reticulum to the Golgi, where it is processed. {ECO:0000269|PubMed:12782636}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:12782636}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus (PubMed:10564271, PubMed:12782636). THBS4 promotes its nuclear shuttling (By similarity). {ECO:0000250|UniProtKB:F6VAN0, ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:12782636}.
P18858	reviewed	DNLI1_HUMAN	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1)	LIG1	Homo sapiens (Human)	919	FUNCTION: DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}.		anatomical structure morphogenesis [GO:0009653]; base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; cell division [GO:0051301]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; lagging strand elongation [GO:0006273]; mismatch repair [GO:0006298]; Okazaki fragment processing involved in mitotic DNA replication [GO:1903461]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; metal ion binding [GO:0046872]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; metal ion binding [GO:0046872]; anatomical structure morphogenesis [GO:0009653]; base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; cell division [GO:0051301]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; lagging strand elongation [GO:0006273]; mismatch repair [GO:0006298]; Okazaki fragment processing involved in mitotic DNA replication [GO:1903461]	SUBCELLULAR LOCATION: Nucleus.
P18859	reviewed	ATP5J_HUMAN	ATP synthase-coupling factor 6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6)	ATP5PF ATP5A ATP5J ATPM	Homo sapiens (Human)	108	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.		proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; substantia nigra development [GO:0021762]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]	proton transmembrane transporter activity [GO:0015078]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]; proton transmembrane transporter activity [GO:0015078]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane.
P18887	reviewed	XRCC1_HUMAN	DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)	XRCC1	Homo sapiens (Human)	633	FUNCTION: Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:34102106, PubMed:34811483, PubMed:28002403). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}.		base-excision repair [GO:0006284]; cerebellum morphogenesis [GO:0021587]; double-strand break repair via nonhomologous end joining [GO:0006303]; hippocampus development [GO:0021766]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of protein ADP-ribosylation [GO:0010836]; positive regulation of DNA ligase activity [GO:1904877]; positive regulation of single strand break repair [GO:1903518]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; response to hydroperoxide [GO:0033194]; response to hypoxia [GO:0001666]; response to organic substance [GO:0010033]; response to xenobiotic stimulus [GO:0009410]; single strand break repair [GO:0000012]; telomeric DNA-containing double minutes formation [GO:0061819]; voluntary musculoskeletal movement [GO:0050882]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; ERCC4-ERCC1 complex [GO:0070522]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	3' overhang single-stranded DNA endodeoxyribonuclease activity [GO:1990599]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; enzyme binding [GO:0019899]; oxidized DNA binding [GO:0032356]; poly-ADP-D-ribose binding [GO:0072572]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; ERCC4-ERCC1 complex [GO:0070522]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; 3' overhang single-stranded DNA endodeoxyribonuclease activity [GO:1990599]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; enzyme binding [GO:0019899]; oxidized DNA binding [GO:0032356]; poly-ADP-D-ribose binding [GO:0072572]; base-excision repair [GO:0006284]; cerebellum morphogenesis [GO:0021587]; double-strand break repair via nonhomologous end joining [GO:0006303]; hippocampus development [GO:0021766]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of protein ADP-ribosylation [GO:0010836]; positive regulation of DNA ligase activity [GO:1904877]; positive regulation of single strand break repair [GO:1903518]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; response to hydroperoxide [GO:0033194]; response to hypoxia [GO:0001666]; response to organic substance [GO:0010033]; response to xenobiotic stimulus [GO:0009410]; single strand break repair [GO:0000012]; telomeric DNA-containing double minutes formation [GO:0061819]; voluntary musculoskeletal movement [GO:0050882]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:28002403}. Chromosome {ECO:0000269|PubMed:14500814}. Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage (PubMed:28002403). Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains (PubMed:14500814). {ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403}.
P19012	reviewed	K1C15_HUMAN	Keratin, type I cytoskeletal 15 (Cytokeratin-15) (CK-15) (Keratin-15) (K15)	KRT15 KRTB	Homo sapiens (Human)	456		MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; nucleus [GO:0005634]	scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
P19013	reviewed	K2C4_HUMAN	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Type-II keratin Kb4)	KRT4 CYK4	Homo sapiens (Human)	520		MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; negative regulation of epithelial cell proliferation [GO:0050680]	cell surface [GO:0009986]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nucleus [GO:0005634]	structural constituent of skin epidermis [GO:0030280]	cell surface [GO:0009986]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nucleus [GO:0005634]; structural constituent of skin epidermis [GO:0030280]; cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; negative regulation of epithelial cell proliferation [GO:0050680]	
P19021	reviewed	AMD_HUMAN	Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]	PAM	Homo sapiens (Human)	973	FUNCTION: Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides (PubMed:12699694). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monooxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate (PubMed:12699694). The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate (PubMed:12699694). Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate (By similarity). {ECO:0000250|UniProtKB:P14925, ECO:0000269|PubMed:12699694}.	MISCELLANEOUS: [Isoform 3]: Soluble. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Soluble. {ECO:0000305}.	fatty acid primary amide biosynthetic process [GO:0062112]; peptide amidation [GO:0001519]; response to zinc ion [GO:0010043]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]	calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; L-ascorbic acid binding [GO:0031418]; peptidylamidoglycolate lyase activity [GO:0004598]; peptidylglycine monooxygenase activity [GO:0004504]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]; calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; L-ascorbic acid binding [GO:0031418]; peptidylamidoglycolate lyase activity [GO:0004598]; peptidylglycine monooxygenase activity [GO:0004504]; zinc ion binding [GO:0008270]; fatty acid primary amide biosynthetic process [GO:0062112]; peptide amidation [GO:0001519]; response to zinc ion [GO:0010043]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P10731}; Single-pass membrane protein {ECO:0000250|UniProtKB:P10731}. Note=Secretory granules. {ECO:0000250|UniProtKB:P10731}.; SUBCELLULAR LOCATION: [Isoform 1]: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted. Note=Secreted from secretory granules.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted. Note=Secreted from secretory granules.
P19022	reviewed	CADH2_HUMAN	Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)	CDH2 CDHN NCAD	Homo sapiens (Human)	906	FUNCTION: Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. {ECO:0000250|UniProtKB:P10288, ECO:0000250|UniProtKB:P15116, ECO:0000269|PubMed:31585109}.		adherens junction organization [GO:0034332]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; brain morphogenesis [GO:0048854]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cerebral cortex development [GO:0021987]; detection of muscle stretch [GO:0035995]; glial cell differentiation [GO:0010001]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homeostasis of number of cells [GO:0048872]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; mesenchymal cell migration [GO:0090497]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neural crest cell development [GO:0014032]; neuroepithelial cell differentiation [GO:0060563]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of synaptic vesicle clustering [GO:2000809]; protein localization to plasma membrane [GO:0072659]; radial glial cell differentiation [GO:0060019]; regulation of axonogenesis [GO:0050770]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; regulation of postsynaptic density protein 95 clustering [GO:1902897]; regulation of synaptic transmission, glutamatergic [GO:0051966]; striated muscle cell differentiation [GO:0051146]; synapse assembly [GO:0007416]; synaptic vesicle clustering [GO:0097091]; type B pancreatic cell development [GO:0003323]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; endoplasmic reticulum lumen [GO:0005788]; fascia adherens [GO:0005916]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; sarcolemma [GO:0042383]	alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; endoplasmic reticulum lumen [GO:0005788]; fascia adherens [GO:0005916]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; adherens junction organization [GO:0034332]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; brain morphogenesis [GO:0048854]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cerebral cortex development [GO:0021987]; detection of muscle stretch [GO:0035995]; glial cell differentiation [GO:0010001]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homeostasis of number of cells [GO:0048872]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; mesenchymal cell migration [GO:0090497]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neural crest cell development [GO:0014032]; neuroepithelial cell differentiation [GO:0060563]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of synaptic vesicle clustering [GO:2000809]; protein localization to plasma membrane [GO:0072659]; radial glial cell differentiation [GO:0060019]; regulation of axonogenesis [GO:0050770]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; regulation of postsynaptic density protein 95 clustering [GO:1902897]; regulation of synaptic transmission, glutamatergic [GO:0051966]; striated muscle cell differentiation [GO:0051146]; synapse assembly [GO:0007416]; synaptic vesicle clustering [GO:0097091]; type B pancreatic cell development [GO:0003323]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P15116}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P15116}. Cell junction {ECO:0000269|PubMed:28169360}. Cell surface {ECO:0000250|UniProtKB:P15116}. Cell junction, desmosome {ECO:0000250|UniProtKB:P15116}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P15116}. Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes. {ECO:0000250|UniProtKB:P15116}.
P19075	reviewed	TSN8_HUMAN	Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3) (Tumor-associated antigen CO-029)	TSPAN8 TM4SF3	Homo sapiens (Human)	237			negative regulation of blood coagulation [GO:0030195]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	integrin binding [GO:0005178]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; integrin binding [GO:0005178]; negative regulation of blood coagulation [GO:0030195]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P19086	reviewed	GNAZ_HUMAN	Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha)	GNAZ	Homo sapiens (Human)	355	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; negative regulation of insulin secretion [GO:0046676]	cell body [GO:0044297]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; heterotrimeric G-protein complex [GO:0005834]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]	adenylate cyclase inhibitor activity [GO:0010855]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled serotonin receptor binding [GO:0031821]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	cell body [GO:0044297]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; heterotrimeric G-protein complex [GO:0005834]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; adenylate cyclase inhibitor activity [GO:0010855]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled serotonin receptor binding [GO:0031821]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; negative regulation of insulin secretion [GO:0046676]	SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
P19087	reviewed	GNAT2_HUMAN	Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain)	GNAT2 GNATC	Homo sapiens (Human)	354	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; background adaptation [GO:0120302]; cell morphogenesis [GO:0000902]; cone retinal bipolar cell differentiation [GO:1904390]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; detection of light stimulus involved in visual perception [GO:0050908]; dopamine metabolic process [GO:0042417]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; homeostasis of number of retina cells [GO:0048877]; L-glutamate import [GO:0051938]; neural tissue regeneration [GO:0097719]; phototransduction [GO:0007602]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein localization [GO:0008104]; reactive gliosis [GO:0150103]; response to organic cyclic compound [GO:0014070]; response to UV [GO:0009411]; retinal cone cell development [GO:0046549]; retinal rod cell differentiation [GO:0060221]; tissue remodeling [GO:0048771]; visual behavior [GO:0007632]; visual perception [GO:0007601]	heterotrimeric G-protein complex [GO:0005834]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	heterotrimeric G-protein complex [GO:0005834]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; background adaptation [GO:0120302]; cell morphogenesis [GO:0000902]; cone retinal bipolar cell differentiation [GO:1904390]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; detection of light stimulus involved in visual perception [GO:0050908]; dopamine metabolic process [GO:0042417]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; homeostasis of number of retina cells [GO:0048877]; L-glutamate import [GO:0051938]; neural tissue regeneration [GO:0097719]; phototransduction [GO:0007602]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein localization [GO:0008104]; reactive gliosis [GO:0150103]; response to organic cyclic compound [GO:0014070]; response to UV [GO:0009411]; retinal cone cell development [GO:0046549]; retinal rod cell differentiation [GO:0060221]; tissue remodeling [GO:0048771]; visual behavior [GO:0007632]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P50149}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P50149}. Note=Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light. {ECO:0000250|UniProtKB:P50149}.
P19099	reviewed	C11B2_HUMAN	Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Corticosterone 18-monooxygenase, CYP11B2) (EC 1.14.15.5) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Steroid 11-beta-hydroxylase, CYP11B2) (EC 1.14.15.4) (Steroid 18-hydroxylase)	CYP11B2	Homo sapiens (Human)	503	FUNCTION: A cytochrome P450 monooxygenase that catalyzes the biosynthesis of aldosterone, the main mineralocorticoid in the human body responsible for salt and water homeostasis, thus involved in blood pressure regulation, arterial hypertension, and the development of heart failure (PubMed:1775135, PubMed:1518866, PubMed:9814482, PubMed:15356073, PubMed:12530636, PubMed:22446688, PubMed:11856349, PubMed:23322723, PubMed:1594605, PubMed:9814506). Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone (21-hydroxyprogesterone), namely 11-beta hydroxylation, followed by two successive oxidations at C18 yielding 18-hydroxy and then 18-oxo intermediates (that would not leave the enzyme active site during the consecutive hydroxylation reactions), ending with the formation of aldosterone (PubMed:1775135, PubMed:1518866, PubMed:12530636, PubMed:22446688, PubMed:11856349, PubMed:23322723, PubMed:1594605, PubMed:9814506). Can also produce 18-hydroxycortisol and 18-oxocortisol, derived from successive oxidations of cortisol at C18, normally found at very low levels, but significantly increased in primary aldosteronism, the most common form of secondary hypertension (PubMed:15356073, PubMed:9814482). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:11856349, PubMed:1594605, PubMed:23322723, PubMed:9814506). Could also be involved in the androgen metabolic pathway (Probable). {ECO:0000269|PubMed:11856349, ECO:0000269|PubMed:12530636, ECO:0000269|PubMed:1518866, ECO:0000269|PubMed:15356073, ECO:0000269|PubMed:1594605, ECO:0000269|PubMed:1775135, ECO:0000269|PubMed:22446688, ECO:0000269|PubMed:23322723, ECO:0000269|PubMed:9814482, ECO:0000269|PubMed:9814506, ECO:0000305|PubMed:23322723}.	MISCELLANEOUS: Expressed in aldosterone-secreting tumors and in adrenal glands of patients with idiopathic hyperaldosteronism. {ECO:0000269|PubMed:2040591}.	aldosterone biosynthetic process [GO:0032342]; C21-steroid hormone biosynthetic process [GO:0006700]; cellular response to hormone stimulus [GO:0032870]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to potassium ion [GO:0035865]; cholesterol metabolic process [GO:0008203]; cortisol biosynthetic process [GO:0034651]; cortisol metabolic process [GO:0034650]; glucocorticoid biosynthetic process [GO:0006704]; mineralocorticoid biosynthetic process [GO:0006705]; potassium ion homeostasis [GO:0055075]; regulation of blood volume by renal aldosterone [GO:0002017]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; sterol metabolic process [GO:0016125]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	corticosterone 18-monooxygenase activity [GO:0047783]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 11-beta-monooxygenase activity [GO:0004507]; steroid hydroxylase activity [GO:0008395]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; corticosterone 18-monooxygenase activity [GO:0047783]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 11-beta-monooxygenase activity [GO:0004507]; steroid hydroxylase activity [GO:0008395]; aldosterone biosynthetic process [GO:0032342]; C21-steroid hormone biosynthetic process [GO:0006700]; cellular response to hormone stimulus [GO:0032870]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to potassium ion [GO:0035865]; cholesterol metabolic process [GO:0008203]; cortisol biosynthetic process [GO:0034651]; cortisol metabolic process [GO:0034650]; glucocorticoid biosynthetic process [GO:0006704]; mineralocorticoid biosynthetic process [GO:0006705]; potassium ion homeostasis [GO:0055075]; regulation of blood volume by renal aldosterone [GO:0002017]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; sterol metabolic process [GO:0016125]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P14137}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14137}.
P19105	reviewed	ML12A_HUMAN	Myosin regulatory light chain 12A (Epididymis secretory protein Li 24) (HEL-S-24) (MLC-2B) (Myosin RLC) (Myosin regulatory light chain 2, nonsarcomeric) (Myosin regulatory light chain MRLC3)	MYL12A MLCB MRLC3 RLC	Homo sapiens (Human)	171	FUNCTION: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). {ECO:0000250}.	MISCELLANEOUS: This chain binds calcium.	platelet aggregation [GO:0070527]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myosin II complex [GO:0016460]; stress fiber [GO:0001725]; Z disc [GO:0030018]	calcium ion binding [GO:0005509]; glutamate receptor binding [GO:0035254]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myosin II complex [GO:0016460]; stress fiber [GO:0001725]; Z disc [GO:0030018]; calcium ion binding [GO:0005509]; glutamate receptor binding [GO:0035254]; platelet aggregation [GO:0070527]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]	
P19113	reviewed	DCHS_HUMAN	Histidine decarboxylase (HDC) (EC 4.1.1.22)	HDC	Homo sapiens (Human)	662	FUNCTION: Catalyzes the biosynthesis of histamine from histidine. {ECO:0000269|PubMed:22767596}.		catecholamine biosynthetic process [GO:0042423]; histamine biosynthetic process [GO:0001694]; histidine catabolic process [GO:0006548]; histidine metabolic process [GO:0006547]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	histidine decarboxylase activity [GO:0004398]; pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; histidine decarboxylase activity [GO:0004398]; pyridoxal phosphate binding [GO:0030170]; catecholamine biosynthetic process [GO:0042423]; histamine biosynthetic process [GO:0001694]; histidine catabolic process [GO:0006548]; histidine metabolic process [GO:0006547]	
P19174	reviewed	PLCG1_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)	PLCG1 PLC1	Homo sapiens (Human)	1290	FUNCTION: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814}.		calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc-epsilon receptor signaling pathway [GO:0038095]; in utero embryonic development [GO:0001701]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid catabolic process [GO:0009395]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; release of sequestered calcium ion into cytosol [GO:0051209]; T cell receptor signaling pathway [GO:0050852]	cell projection [GO:0042995]; cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; Schaffer collateral - CA1 synapse [GO:0098685]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase C activity [GO:0050429]; glutamate receptor binding [GO:0035254]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; protein kinase binding [GO:0019901]; receptor tyrosine kinase binding [GO:0030971]	cell projection [GO:0042995]; cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; Schaffer collateral - CA1 synapse [GO:0098685]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase C activity [GO:0050429]; glutamate receptor binding [GO:0035254]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; protein kinase binding [GO:0019901]; receptor tyrosine kinase binding [GO:0030971]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc-epsilon receptor signaling pathway [GO:0038095]; in utero embryonic development [GO:0001701]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid catabolic process [GO:0009395]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; release of sequestered calcium ion into cytosol [GO:0051209]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000269|PubMed:17229814}. Cell projection, ruffle {ECO:0000269|PubMed:17229814}. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. {ECO:0000269|PubMed:17229814}.
P19224	reviewed	UD16_HUMAN	UDP-glucuronosyltransferase 1-6 (UDPGT 1-6) (UGT1*6) (UGT1-06) (UGT1.6) (EC 2.4.1.17) (Phenol-metabolizing UDP-glucuronosyltransferase) (UDP-glucuronosyltransferase 1-F) (UGT-1F) (UGT1F) (UDP-glucuronosyltransferase 1A6)	UGT1A6 GNT1 UGT1	Homo sapiens (Human)	532	FUNCTION: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). {ECO:0000250}.	MISCELLANEOUS: The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.	cellular glucuronidation [GO:0052695]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; cellular glucuronidation [GO:0052695]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P19235	reviewed	EPOR_HUMAN	Erythropoietin receptor (EPO-R)	EPOR	Homo sapiens (Human)	508	FUNCTION: Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.; FUNCTION: Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.		brain development [GO:0007420]; cytokine-mediated signaling pathway [GO:0019221]; decidualization [GO:0046697]; heart development [GO:0007507]; hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284]; signal transduction [GO:0007165]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]	erythropoietin receptor activity [GO:0004900]; identical protein binding [GO:0042802]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; erythropoietin receptor activity [GO:0004900]; identical protein binding [GO:0042802]; brain development [GO:0007420]; cytokine-mediated signaling pathway [GO:0019221]; decidualization [GO:0046697]; heart development [GO:0007507]; hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform EPOR-S]: Secreted {ECO:0000269|PubMed:11722595}. Note=Secreted and located to the cell surface.
P19237	reviewed	TNNI1_HUMAN	Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform)	TNNI1	Homo sapiens (Human)	187	FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.		cardiac muscle contraction [GO:0060048]; regulation of striated muscle contraction [GO:0006942]; skeletal muscle contraction [GO:0003009]; transition between fast and slow fiber [GO:0014883]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	cytosol [GO:0005829]; troponin complex [GO:0005861]	actin binding [GO:0003779]	cytosol [GO:0005829]; troponin complex [GO:0005861]; actin binding [GO:0003779]; cardiac muscle contraction [GO:0060048]; regulation of striated muscle contraction [GO:0006942]; skeletal muscle contraction [GO:0003009]; transition between fast and slow fiber [GO:0014883]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	
P19256	reviewed	LFA3_HUMAN	Lymphocyte function-associated antigen 3 (Ag3) (Surface glycoprotein LFA-3) (CD antigen CD58)	CD58 LFA3	Homo sapiens (Human)	250	FUNCTION: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000269|PubMed:14759258}.	cell-cell adhesion [GO:0098609]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; heterotypic cell-cell adhesion [GO:0034113]; positive regulation of interleukin-8 production [GO:0032757]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; signaling receptor binding [GO:0005102]; cell-cell adhesion [GO:0098609]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; heterotypic cell-cell adhesion [GO:0034113]; positive regulation of interleukin-8 production [GO:0032757]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.
P19320	reviewed	VCAM1_HUMAN	Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1]	VCAM1	Homo sapiens (Human)	739	FUNCTION: Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034). During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration (PubMed:22970700). Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation (PubMed:35210567). {ECO:0000269|PubMed:10209034, ECO:0000269|PubMed:22970700, ECO:0000269|PubMed:31310649, ECO:0000269|PubMed:35210567}.	MISCELLANEOUS: [Isoform 1]: Major isoform.	amine metabolic process [GO:0009308]; B cell differentiation [GO:0030183]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cardiac neuron differentiation [GO:0060945]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell adhesion in response to extracellular stimulus [GO:0140039]; cell-matrix adhesion [GO:0007160]; cellular response to amyloid-beta [GO:1904646]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chronic inflammatory response [GO:0002544]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; heterotypic cell-cell adhesion [GO:0034113]; inflammatory response [GO:0006954]; innervation [GO:0060384]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; positive regulation of T cell proliferation [GO:0042102]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to nutrient [GO:0007584]; response to zinc ion [GO:0010043]	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex [GO:0071065]; apical part of cell [GO:0045177]; cell surface [GO:0009986]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; podosome [GO:0002102]; sarcolemma [GO:0042383]	cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; primary amine oxidase activity [GO:0008131]	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex [GO:0071065]; apical part of cell [GO:0045177]; cell surface [GO:0009986]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; podosome [GO:0002102]; sarcolemma [GO:0042383]; cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; primary amine oxidase activity [GO:0008131]; amine metabolic process [GO:0009308]; B cell differentiation [GO:0030183]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cardiac neuron differentiation [GO:0060945]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell adhesion in response to extracellular stimulus [GO:0140039]; cell-matrix adhesion [GO:0007160]; cellular response to amyloid-beta [GO:1904646]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chronic inflammatory response [GO:0002544]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; heterotypic cell-cell adhesion [GO:0034113]; inflammatory response [GO:0006954]; innervation [GO:0060384]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; positive regulation of T cell proliferation [GO:0042102]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to nutrient [GO:0007584]; response to zinc ion [GO:0010043]	SUBCELLULAR LOCATION: [Vascular cell adhesion protein 1]: Cell membrane {ECO:0000305|PubMed:12878595}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Soluble Vascular Cell Adhesion Molecule-1]: Secreted {ECO:0000269|PubMed:12878595, ECO:0000269|PubMed:36127634}.
P19338	reviewed	NUCL_HUMAN	Nucleolin (Protein C23)	NCL	Homo sapiens (Human)	710	FUNCTION: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}.		angiogenesis [GO:0001525]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of translation [GO:0017148]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]	cell cortex [GO:0005938]; chromosome [GO:0005694]; cornified envelope [GO:0001533]; cytoplasmic ribonucleoprotein granule [GO:0036464]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]	DNA topoisomerase binding [GO:0044547]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; mRNA 5'-UTR binding [GO:0048027]; PH domain binding [GO:0042731]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]	cell cortex [GO:0005938]; chromosome [GO:0005694]; cornified envelope [GO:0001533]; cytoplasmic ribonucleoprotein granule [GO:0036464]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; DNA topoisomerase binding [GO:0044547]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; mRNA 5'-UTR binding [GO:0048027]; PH domain binding [GO:0042731]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]; angiogenesis [GO:0001525]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of translation [GO:0017148]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
P19367	reviewed	HXK1_HUMAN	Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A)	HK1	Homo sapiens (Human)	917	FUNCTION: Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}.		canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; establishment of protein localization to mitochondrion [GO:0072655]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular glucose homeostasis [GO:0001678]; maintenance of protein location in mitochondrion [GO:0072656]; mannose metabolic process [GO:0006013]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-1 beta production [GO:0032731]	cytosol [GO:0005829]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucosamine kinase activity [GO:0047931]; glucose binding [GO:0005536]; hexokinase activity [GO:0004396]; mannokinase activity [GO:0019158]; peptidoglycan binding [GO:0042834]	cytosol [GO:0005829]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucosamine kinase activity [GO:0047931]; glucose binding [GO:0005536]; hexokinase activity [GO:0004396]; mannokinase activity [GO:0019158]; peptidoglycan binding [GO:0042834]; canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; establishment of protein localization to mitochondrion [GO:0072655]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular glucose homeostasis [GO:0001678]; maintenance of protein location in mitochondrion [GO:0072656]; mannose metabolic process [GO:0006013]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-1 beta production [GO:0032731]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:1985912, ECO:0000269|PubMed:27374331}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:27374331}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (Probable). Dissociates from the mitochondrial outer membrane following inhibition by N-acetyl-D-glucosamine, leading to relocation to the cytosol (PubMed:27374331). {ECO:0000269|PubMed:27374331, ECO:0000305|PubMed:1985912}.
P19387	reviewed	RPB3_HUMAN	DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31)	POLR2C A-152E5.7	Homo sapiens (Human)	275	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.		transcription by RNA polymerase II [GO:0006366]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
P19388	reviewed	RPAB1_HUMAN	DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4)	POLR2E	Homo sapiens (Human)	210	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.		protein stabilization [GO:0050821]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein stabilization [GO:0050821]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
P19397	reviewed	CD53_HUMAN	Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)	CD53 MOX44 TSPAN25	Homo sapiens (Human)	219	FUNCTION: Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity). {ECO:0000250}.		positive regulation of myoblast fusion [GO:1901741]; signal transduction [GO:0007165]	cell surface [GO:0009986]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	identical protein binding [GO:0042802]	cell surface [GO:0009986]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; identical protein binding [GO:0042802]; positive regulation of myoblast fusion [GO:1901741]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cell junction {ECO:0000250}. Membrane; Multi-pass membrane protein. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes. {ECO:0000250}.
P19404	reviewed	NDUV2_HUMAN	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 7.1.1.2) (NADH-ubiquinone oxidoreductase 24 kDa subunit)	NDUFV2	Homo sapiens (Human)	249	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. {ECO:0000250|UniProtKB:P04394}.		aerobic respiration [GO:0009060]; cardiac muscle tissue development [GO:0048738]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; nervous system development [GO:0007399]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; cardiac muscle tissue development [GO:0048738]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; nervous system development [GO:0007399]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P04394}; Peripheral membrane protein {ECO:0000250|UniProtKB:P04394}; Matrix side {ECO:0000250|UniProtKB:P04394}.
P19419	reviewed	ELK1_HUMAN	ETS domain-containing protein Elk-1	ELK1	Homo sapiens (Human)	428	FUNCTION: Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity). {ECO:0000250|UniProtKB:A4GTP4, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}.		cellular response to gamma radiation [GO:0071480]; cellular response to testosterone stimulus [GO:0071394]; gene expression [GO:0010467]; hippocampal neuron apoptotic process [GO:0110088]; liver development [GO:0001889]; lung development [GO:0030324]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to fibroblast growth factor [GO:0071774]; response to light stimulus [GO:0009416]	axon terminus [GO:0043679]; chromatin [GO:0000785]; dendrite [GO:0030425]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor coactivator activity [GO:0030374]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	axon terminus [GO:0043679]; chromatin [GO:0000785]; dendrite [GO:0030425]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor coactivator activity [GO:0030374]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cellular response to gamma radiation [GO:0071480]; cellular response to testosterone stimulus [GO:0071394]; gene expression [GO:0010467]; hippocampal neuron apoptotic process [GO:0110088]; liver development [GO:0001889]; lung development [GO:0030324]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to fibroblast growth factor [GO:0071774]; response to light stimulus [GO:0009416]	SUBCELLULAR LOCATION: Nucleus.
P19429	reviewed	TNNI3_HUMAN	Troponin I, cardiac muscle (Cardiac troponin I)	TNNI3 TNNC1	Homo sapiens (Human)	210	FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.		cardiac muscle contraction [GO:0060048]; heart contraction [GO:0060047]; heart development [GO:0007507]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of ATP-dependent activity [GO:0032780]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of smooth muscle contraction [GO:0006940]; regulation of systemic arterial blood pressure by ischemic conditions [GO:0001980]; skeletal muscle contraction [GO:0003009]; vasculogenesis [GO:0001570]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	cardiac myofibril [GO:0097512]; cardiac Troponin complex [GO:1990584]; cytosol [GO:0005829]; sarcomere [GO:0030017]; troponin complex [GO:0005861]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium channel inhibitor activity [GO:0019855]; calcium-dependent protein binding [GO:0048306]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; troponin C binding [GO:0030172]; troponin T binding [GO:0031014]	cardiac myofibril [GO:0097512]; cardiac Troponin complex [GO:1990584]; cytosol [GO:0005829]; sarcomere [GO:0030017]; troponin complex [GO:0005861]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium channel inhibitor activity [GO:0019855]; calcium-dependent protein binding [GO:0048306]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; troponin C binding [GO:0030172]; troponin T binding [GO:0031014]; cardiac muscle contraction [GO:0060048]; heart contraction [GO:0060047]; heart development [GO:0007507]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of ATP-dependent activity [GO:0032780]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of smooth muscle contraction [GO:0006940]; regulation of systemic arterial blood pressure by ischemic conditions [GO:0001980]; skeletal muscle contraction [GO:0003009]; vasculogenesis [GO:0001570]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	
P19438	reviewed	TNR1A_HUMAN	Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]	TNFRSF1A TNFAR TNFR1	Homo sapiens (Human)	455	FUNCTION: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.	MISCELLANEOUS: [Isoform 4]: Disease-associated isoform. Isoform 4 splicing pattern is driven by a variation in the exon 6/intron 6 boundary region that alters exon 6 splicing. Exon 6 skipping introduces a frameshift and the translation of a protein lacking the intracellular, the transmembrane and part of the extracellular domain. {ECO:0000305}.	aortic valve development [GO:0003176]; cellular response to mechanical stimulus [GO:0071260]; cytokine-mediated signaling pathway [GO:0019221]; defense response to bacterium [GO:0042742]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of inflammatory response [GO:0050728]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of inflammatory response [GO:0050729]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; prostaglandin metabolic process [GO:0006693]; protein localization to plasma membrane [GO:0072659]; pulmonary valve development [GO:0003177]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; transcription by RNA polymerase II [GO:0006366]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; tumor necrosis factor receptor superfamily complex [GO:0002947]	tumor necrosis factor binding [GO:0043120]; tumor necrosis factor receptor activity [GO:0005031]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; tumor necrosis factor receptor superfamily complex [GO:0002947]; tumor necrosis factor binding [GO:0043120]; tumor necrosis factor receptor activity [GO:0005031]; aortic valve development [GO:0003176]; cellular response to mechanical stimulus [GO:0071260]; cytokine-mediated signaling pathway [GO:0019221]; defense response to bacterium [GO:0042742]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of inflammatory response [GO:0050728]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of inflammatory response [GO:0050729]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; prostaglandin metabolic process [GO:0006693]; protein localization to plasma membrane [GO:0072659]; pulmonary valve development [GO:0003177]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; transcription by RNA polymerase II [GO:0006366]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22801493}; Single-pass type I membrane protein {ECO:0000269|PubMed:22801493}. Golgi apparatus membrane {ECO:0000269|PubMed:22801493}; Single-pass type I membrane protein {ECO:0000269|PubMed:22801493}. Secreted {ECO:0000269|PubMed:22801493}. Note=A secreted form is produced through proteolytic processing.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted. Note=Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
P19440	reviewed	GGT1_HUMAN	Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]	GGT1 GGT	Homo sapiens (Human)	569	FUNCTION: Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4) (PubMed:17924658, PubMed:21447318, PubMed:27791009). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases (PubMed:27791009). In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:17924658, PubMed:7673200, PubMed:7759490, PubMed:8095045, PubMed:8827453, PubMed:21447318). Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4. {ECO:0000269|PubMed:17924658, ECO:0000269|PubMed:20622017, ECO:0000269|PubMed:21447318, ECO:0000269|PubMed:24047895, ECO:0000269|PubMed:27791009, ECO:0000269|PubMed:7673200, ECO:0000269|PubMed:7759490, ECO:0000269|PubMed:8095045, ECO:0000269|PubMed:8827453}.; FUNCTION: [Isoform 3]: Seems to be inactive. {ECO:0000269|PubMed:7689219}.	MISCELLANEOUS: Cys-454 was thought to bind the gamma-glutamyl moiety, but mutagenesis of this residue had no effect on activity. {ECO:0000269|PubMed:7759490}.; MISCELLANEOUS: Chloride ions bound in the active site cavity may contribute to stabilize the protein fold. {ECO:0000305|PubMed:24047895}.; MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000305}.	amino acid metabolic process [GO:0006520]; cysteine biosynthetic process [GO:0019344]; fatty acid metabolic process [GO:0006631]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]; leukotriene metabolic process [GO:0006691]; peptide modification [GO:0031179]; proteolysis [GO:0006508]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; spermatogenesis [GO:0007283]; zymogen activation [GO:0031638]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; leukotriene-C(4) hydrolase [GO:0002951]; peptidyltransferase activity [GO:0000048]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; leukotriene-C(4) hydrolase [GO:0002951]; peptidyltransferase activity [GO:0000048]; amino acid metabolic process [GO:0006520]; cysteine biosynthetic process [GO:0019344]; fatty acid metabolic process [GO:0006631]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]; leukotriene metabolic process [GO:0006691]; peptide modification [GO:0031179]; proteolysis [GO:0006508]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; spermatogenesis [GO:0007283]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23682772, ECO:0000269|PubMed:8095045}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P07314}.
P19447	reviewed	ERCC3_HUMAN	General transcription and DNA repair factor IIH helicase subunit XPB (TFIIH subunit XPB) (EC 3.6.4.12) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein)	ERCC3 XPB XPBC	Homo sapiens (Human)	782	FUNCTION: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation (PubMed:8157004, PubMed:30894545). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:30894545, ECO:0000269|PubMed:8157004}.		apoptotic process [GO:0006915]; DNA repair [GO:0006281]; DNA topological change [GO:0006265]; embryonic organ development [GO:0048568]; hair cell differentiation [GO:0035315]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA duplex unwinding [GO:0000717]; positive regulation of apoptotic process [GO:0043065]; protein localization [GO:0008104]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]; UV protection [GO:0009650]	nucleoplasm [GO:0005654]; nucleotide-excision repair factor 3 complex [GO:0000112]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription preinitiation complex [GO:0097550]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; promoter-specific chromatin binding [GO:1990841]	nucleoplasm [GO:0005654]; nucleotide-excision repair factor 3 complex [GO:0000112]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription preinitiation complex [GO:0097550]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; promoter-specific chromatin binding [GO:1990841]; apoptotic process [GO:0006915]; DNA repair [GO:0006281]; DNA topological change [GO:0006265]; embryonic organ development [GO:0048568]; hair cell differentiation [GO:0035315]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA duplex unwinding [GO:0000717]; positive regulation of apoptotic process [GO:0043065]; protein localization [GO:0008104]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]; UV protection [GO:0009650]	SUBCELLULAR LOCATION: Nucleus.
P19474	reviewed	RO52_HUMAN	E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)	TRIM21 RNF81 RO52 SSA1	Homo sapiens (Human)	475	FUNCTION: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2 (PubMed:26347139, PubMed:16297862, PubMed:16316627, PubMed:16472766, PubMed:16880511, PubMed:18022694, PubMed:18361920, PubMed:18641315, PubMed:18845142, PubMed:19675099). Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination (PubMed:16880511, PubMed:19675099). Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes (PubMed:16880511). A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome (PubMed:16880511). Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling (PubMed:19675099). Negatively regulates IFN-beta production post-pathogen recognition by catalyzing polyubiquitin-mediated degradation of IRF3 (PubMed:18641315). Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway (PubMed:18022694). Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages (By similarity). Plays a role in the regulation of the cell cycle progression (PubMed:16880511). Enhances the decapping activity of DCP2 (PubMed:18361920). Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules (PubMed:1985094, PubMed:8666824). At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified (PubMed:8666824). The common feature of these proteins is their ability to bind HY RNAs.2 (PubMed:8666824). Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:26347139). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (PubMed:26347139). Regulates also autophagy through FIP200/RB1CC1 ubiquitination and subsequent decreased protein stability (PubMed:36359729). Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI (PubMed:26342464). During viral infection, promotes cell pyroptosis by mediating 'Lys-6'-linked ubiquitination of ISG12a/IFI27, facilitating its translocation into the mitochondria and subsequent CASP3 activation (PubMed:36426955). When up-regulated through the IFN/JAK/STAT signaling pathway, promotes 'Lys-27'-linked ubiquitination of MAVS, leading to the recruitment of TBK1 and up-regulation of innate immunity (PubMed:29743353). Mediates 'Lys-63'-linked polyubiquitination of G3BP1 in response to heat shock, leading to stress granule disassembly (PubMed:36692217). {ECO:0000250|UniProtKB:Q62191, ECO:0000269|PubMed:16297862, ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:16880511, ECO:0000269|PubMed:18022694, ECO:0000269|PubMed:18361920, ECO:0000269|PubMed:18641315, ECO:0000269|PubMed:18845142, ECO:0000269|PubMed:19675099, ECO:0000269|PubMed:1985094, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:26347139, ECO:0000269|PubMed:29743353, ECO:0000269|PubMed:36359729, ECO:0000269|PubMed:36426955, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:8666824}.		cell cycle [GO:0007049]; cellular response to chemical stress [GO:0062197]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein deubiquitination [GO:0090086]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of protein binding [GO:0032092]; positive regulation of viral entry into host cell [GO:0046598]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; pyroptosis [GO:0070269]; regulation of protein localization [GO:0032880]; regulation of type I interferon production [GO:0032479]; regulation of viral entry into host cell [GO:0046596]; response to type II interferon [GO:0034341]; suppression of viral release by host [GO:0044790]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; cellular response to chemical stress [GO:0062197]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein deubiquitination [GO:0090086]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of protein binding [GO:0032092]; positive regulation of viral entry into host cell [GO:0046598]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; pyroptosis [GO:0070269]; regulation of protein localization [GO:0032880]; regulation of type I interferon production [GO:0032479]; regulation of viral entry into host cell [GO:0046596]; response to type II interferon [GO:0034341]; suppression of viral release by host [GO:0044790]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:26347139, ECO:0000269|PubMed:36426955}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:26347139}. Nucleus {ECO:0000269|PubMed:17156811}. Cytoplasm, P-body {ECO:0000269|PubMed:18361920}. Cytoplasm, Stress granule {ECO:0000269|PubMed:17156811}. Note=Enters the nucleus upon exposure to nitric oxide (PubMed:18361920). Localizes to small dot- or rod-like structures in the cytoplasm, called processing bodies (P-bodies) that are located underneath the plasma membrane and also diffusely in the cytoplasm (PubMed:18361920). They are located along the microtubules and are highly motile in cells (PubMed:18361920). Colocalizes with DCP2 in P-bodies (PubMed:18361920). Localizes to stress granules in response to oxidative stress (PubMed:36692217). {ECO:0000269|PubMed:18361920, ECO:0000269|PubMed:36692217}.
P19484	reviewed	TFEB_HUMAN	Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35)	TFEB BHLHE35	Homo sapiens (Human)	476	FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}.		adaptive immune response [GO:0002250]; antibacterial innate immune response [GO:0140367]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; cellular response to starvation [GO:0009267]; embryonic placenta development [GO:0001892]; humoral immune response [GO:0006959]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; adaptive immune response [GO:0002250]; antibacterial innate immune response [GO:0140367]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; cellular response to starvation [GO:0009267]; embryonic placenta development [GO:0001892]; humoral immune response [GO:0006959]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23401004, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27184844, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:33691586, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37079666}. Cytoplasm, cytosol {ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:23401004, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27184844, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:33691586, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37079666}. Lysosome membrane {ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23401004, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:36697823}. Note=Mainly present in the cytoplasm (PubMed:23434374, PubMed:33691586, PubMed:35662396). When nutrients are present, recruited to the lysosomal membrane via association with GDP-bound RagC/RRAGC (or RagD/RRAGD): it is then phosphorylated by MTOR (PubMed:23401004, PubMed:32612235, PubMed:36697823). Phosphorylation by MTOR prevents nuclear translocation and activity by promoting interaction with 14-3-3 proteins, such as YWHAZ (PubMed:22343943, PubMed:22692423, PubMed:23401004, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:37079666). Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:25720963, PubMed:32753672). The translocation to the nucleus is regulated by ATP13A2 (PubMed:23434374, PubMed:27278822). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:22343943, PubMed:22692423, PubMed:37079666). Exported from the nucleus in response to nutrient availability (PubMed:30120233). In macrophages, translocates into the nucleus upon live S.enterica infection (PubMed:27184844). {ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23401004, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27184844, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:33691586, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37079666}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33691586}. Note=(Microbial infection) Following Coxsackievirus B3 infection, full length TFEB and viral protease 3C-mediated cleavage product are translocated from the cytoplasm to the nucleus. {ECO:0000269|PubMed:33691586}.
P19525	reviewed	E2AK2_HUMAN	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)	EIF2AK2 PKR PRKR	Homo sapiens (Human)	551	FUNCTION: IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19507191, PubMed:19189853, PubMed:21123651, PubMed:21072047, PubMed:22948139, PubMed:23229543, PubMed:22381929). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:20171114, PubMed:19840259, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:22214662, PubMed:19229320). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}.		antiviral innate immune response [GO:0140374]; cellular response to amino acid starvation [GO:0034198]; defense response to virus [GO:0051607]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of NLRP3 inflammasome complex assembly [GO:1900225]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]	ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein phosphatase regulator activity [GO:0019888]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein phosphatase regulator activity [GO:0019888]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; antiviral innate immune response [GO:0140374]; cellular response to amino acid starvation [GO:0034198]; defense response to virus [GO:0051607]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of NLRP3 inflammasome complex assembly [GO:1900225]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:21029237, ECO:0000269|PubMed:22214662}. Nucleus {ECO:0000269|PubMed:21029237, ECO:0000269|PubMed:21072047}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15121867}. Note=Nuclear localization is elevated in acute leukemia, myelodysplastic syndrome (MDS), melanoma, breast, colon, prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced Creutzfeldt-Jakob disease patients. {ECO:0000269|PubMed:21072047}.
P19526	reviewed	FUT1_HUMAN	Galactoside alpha-(1,2)-fucosyltransferase 1 (Alpha(1,2)FT 1) (Blood group H alpha 2-fucosyltransferase) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.344)	FUT1 H HSC	Homo sapiens (Human)	365	FUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:2118655). H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (PubMed:18205178). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity). {ECO:0000250|UniProtKB:O09160, ECO:0000269|PubMed:18205178, ECO:0000269|PubMed:2118655}.	MISCELLANEOUS: There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively. {ECO:0000305}.	carbohydrate metabolic process [GO:0005975]; fucosylation [GO:0036065]; L-fucose catabolic process [GO:0042355]; lipid metabolic process [GO:0006629]; olfactory bulb development [GO:0021772]; oligosaccharide biosynthetic process [GO:0009312]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of sprouting angiogenesis [GO:1903672]; protein glycosylation [GO:0006486]; regulation of cell adhesion [GO:0030155]; regulation of endothelial cell proliferation [GO:0001936]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	alpha-(1,2)-fucosyltransferase activity [GO:0031127]; fucosyltransferase activity [GO:0008417]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; alpha-(1,2)-fucosyltransferase activity [GO:0031127]; fucosyltransferase activity [GO:0008417]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]; carbohydrate metabolic process [GO:0005975]; fucosylation [GO:0036065]; L-fucose catabolic process [GO:0042355]; lipid metabolic process [GO:0006629]; olfactory bulb development [GO:0021772]; oligosaccharide biosynthetic process [GO:0009312]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of sprouting angiogenesis [GO:1903672]; protein glycosylation [GO:0006486]; regulation of cell adhesion [GO:0030155]; regulation of endothelial cell proliferation [GO:0001936]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:O09160}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O09160}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250|UniProtKB:O09160}.
P19532	reviewed	TFE3_HUMAN	Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33)	TFE3 BHLHE33	Homo sapiens (Human)	575	FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:24448649, PubMed:29146937, PubMed:30733432, PubMed:31672913, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:24448649). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:24448649, PubMed:31672913, PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:24448649, PubMed:31672913, PubMed:36608670). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:24448649). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (By similarity). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}.		adaptive immune response [GO:0002250]; humoral immune response [GO:0006959]; lysosome organization [GO:0007040]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of osteoclast differentiation [GO:0045670]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; adaptive immune response [GO:0002250]; humoral immune response [GO:0006959]; lysosome organization [GO:0007040]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of osteoclast differentiation [GO:0045670]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}. Nucleus {ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}. Lysosome membrane {ECO:0000269|PubMed:24448649}. Note=When nutrients are present, recruited to the lysosomal membrane via association with GDP-bound RagC/RRAGC (or RagD/RRAGD): it is then phosphorylated by MTOR (PubMed:24448649, PubMed:37079666). Phosphorylation by MTOR prevents nuclear translocation and promotes ubiquitination and degradation (PubMed:22692423, PubMed:30733432, PubMed:36608670, PubMed:37079666). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:22692423, PubMed:30733432, PubMed:37079666). {ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}.
P19544	reviewed	WT1_HUMAN	Wilms tumor protein (WT33)	WT1	Homo sapiens (Human)	449	FUNCTION: Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). {ECO:0000269|PubMed:15520190, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17716689, ECO:0000269|PubMed:19123921, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:7862533}.	MISCELLANEOUS: Presence of the KTS motif hinders interactions between DNA and zinc-finger 4.; MISCELLANEOUS: [Isoform 1]: Detected in nucleus speckle, may bind mRNA.; MISCELLANEOUS: [Isoform 7]: Produced by alternative initiation of isoform 1. Extended N-terminus. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Produced by alternative initiation of isoform 1. Extended N-terminus. {ECO:0000305}.	adrenal cortex formation [GO:0035802]; adrenal gland development [GO:0030325]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye development [GO:0043010]; cardiac muscle cell fate commitment [GO:0060923]; cellular response to cAMP [GO:0071320]; cellular response to gonadotropin stimulus [GO:0071371]; diaphragm development [GO:0060539]; epithelial cell differentiation [GO:0030855]; germ cell development [GO:0007281]; glomerular basement membrane development [GO:0032836]; glomerulus development [GO:0032835]; gonad development [GO:0008406]; heart development [GO:0007507]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; mesenchymal to epithelial transition [GO:0060231]; metanephric epithelium development [GO:0072207]; metanephric mesenchyme development [GO:0072075]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of female gonad development [GO:2000195]; negative regulation of metanephric glomerular mesangial cell proliferation [GO:0072302]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; podocyte differentiation [GO:0072112]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA methylation [GO:1905643]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of heart growth [GO:0060421]; positive regulation of male gonad development [GO:2000020]; positive regulation of metanephric ureteric bud development [GO:2001076]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; posterior mesonephric tubule development [GO:0072166]; regulation of animal organ formation [GO:0003156]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380]; sex determination [GO:0007530]; thorax and anterior abdomen determination [GO:0007356]; tissue development [GO:0009888]; ureteric bud development [GO:0001657]; vasculogenesis [GO:0001570]; visceral serous pericardium development [GO:0061032]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	C2H2 zinc finger domain binding [GO:0070742]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded methylated DNA binding [GO:0010385]; hemi-methylated DNA-binding [GO:0044729]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; C2H2 zinc finger domain binding [GO:0070742]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded methylated DNA binding [GO:0010385]; hemi-methylated DNA-binding [GO:0044729]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; adrenal cortex formation [GO:0035802]; adrenal gland development [GO:0030325]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye development [GO:0043010]; cardiac muscle cell fate commitment [GO:0060923]; cellular response to cAMP [GO:0071320]; cellular response to gonadotropin stimulus [GO:0071371]; diaphragm development [GO:0060539]; epithelial cell differentiation [GO:0030855]; germ cell development [GO:0007281]; glomerular basement membrane development [GO:0032836]; glomerulus development [GO:0032835]; gonad development [GO:0008406]; heart development [GO:0007507]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; mesenchymal to epithelial transition [GO:0060231]; metanephric epithelium development [GO:0072207]; metanephric mesenchyme development [GO:0072075]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of female gonad development [GO:2000195]; negative regulation of metanephric glomerular mesangial cell proliferation [GO:0072302]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; podocyte differentiation [GO:0072112]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA methylation [GO:1905643]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of heart growth [GO:0060421]; positive regulation of male gonad development [GO:2000020]; positive regulation of metanephric ureteric bud development [GO:2001076]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; posterior mesonephric tubule development [GO:0072166]; regulation of animal organ formation [GO:0003156]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380]; sex determination [GO:0007530]; thorax and anterior abdomen determination [GO:0007356]; tissue development [GO:0009888]; ureteric bud development [GO:0001657]; vasculogenesis [GO:0001570]; visceral serous pericardium development [GO:0061032]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15520190}. Nucleus, nucleolus. Cytoplasm {ECO:0000250}. Note=Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190). Shuttles between nucleus and cytoplasm. {ECO:0000250, ECO:0000269|PubMed:15520190}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus speckle {ECO:0000269|PubMed:15520190}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleoplasm {ECO:0000269|PubMed:15520190}.
P19622	reviewed	HME2_HUMAN	Homeobox protein engrailed-2 (Homeobox protein en-2) (Hu-En-2)	EN2	Homo sapiens (Human)	333			dopaminergic neuron differentiation [GO:0071542]; embryonic brain development [GO:1990403]; hindbrain development [GO:0030902]; midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; dopaminergic neuron differentiation [GO:0071542]; embryonic brain development [GO:1990403]; hindbrain development [GO:0030902]; midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P19623	reviewed	SPEE_HUMAN	Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)	SRM SPS1 SRML1	Homo sapiens (Human)	302	FUNCTION: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine. {ECO:0000269|PubMed:17585781}.		cellular response to leukemia inhibitory factor [GO:1990830]; polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295]	cytosol [GO:0005829]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; spermidine synthase activity [GO:0004766]	cytosol [GO:0005829]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; spermidine synthase activity [GO:0004766]; cellular response to leukemia inhibitory factor [GO:1990830]; polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295]	
P19634	reviewed	SL9A1_HUMAN	Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)	SLC9A1 APNH1 NHE1	Homo sapiens (Human)	815	FUNCTION: Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:7110335, PubMed:7603840, PubMed:11532004, PubMed:11350981, PubMed:15035633, PubMed:14680478, PubMed:17073455, PubMed:22020933, PubMed:27650500, PubMed:15677483, PubMed:32130622, PubMed:17493937). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:8901634, PubMed:12947095, PubMed:15096511, PubMed:22020933). In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}.	MISCELLANEOUS: Predicted models used for more than 20 years predicted 10-12 transmembrane segments (PubMed:9688597, PubMed:10713111). Recently, the stucture of SLC9A1 has been solved and reveals that SLC9A1 posseses 13 transmembranes (PubMed:34108458). {ECO:0000269|PubMed:10713111, ECO:0000269|PubMed:34108458, ECO:0000269|PubMed:9688597}.	cardiac muscle cell contraction [GO:0086003]; cardiac muscle cell differentiation [GO:0055007]; cell migration [GO:0016477]; cellular response to acidic pH [GO:0071468]; cellular response to antibiotic [GO:0071236]; cellular response to cold [GO:0070417]; cellular response to electrical stimulus [GO:0071257]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to mechanical stimulus [GO:0071260]; intracellular sodium ion homeostasis [GO:0006883]; maintenance of cell polarity [GO:0030011]; monoatomic ion transport [GO:0006811]; negative regulation of apoptotic process [GO:0043066]; positive regulation of action potential [GO:0045760]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium:sodium antiporter activity [GO:1903281]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell growth [GO:0030307]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of the force of heart contraction [GO:0098735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; potassium ion transmembrane transport [GO:0071805]; protein complex oligomerization [GO:0051259]; proton transmembrane transport [GO:1902600]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of focal adhesion assembly [GO:0051893]; regulation of intracellular pH [GO:0051453]; regulation of pH [GO:0006885]; regulation of stress fiber assembly [GO:0051492]; regulation of the force of heart contraction by cardiac conduction [GO:0086092]; response to acidic pH [GO:0010447]; response to muscle stretch [GO:0035994]; sodium ion export across plasma membrane [GO:0036376]; sodium ion import across plasma membrane [GO:0098719]; stem cell differentiation [GO:0048863]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cation-transporting ATPase complex [GO:0090533]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]	calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; ion binding [GO:0043167]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipid binding [GO:0005543]; potassium:proton antiporter activity [GO:0015386]; protein phosphatase 2B binding [GO:0030346]; protein-macromolecule adaptor activity [GO:0030674]; sodium:proton antiporter activity [GO:0015385]; sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential [GO:0086040]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cation-transporting ATPase complex [GO:0090533]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; ion binding [GO:0043167]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipid binding [GO:0005543]; potassium:proton antiporter activity [GO:0015386]; protein phosphatase 2B binding [GO:0030346]; protein-macromolecule adaptor activity [GO:0030674]; sodium:proton antiporter activity [GO:0015385]; sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential [GO:0086040]; cardiac muscle cell contraction [GO:0086003]; cardiac muscle cell differentiation [GO:0055007]; cell migration [GO:0016477]; cellular response to acidic pH [GO:0071468]; cellular response to antibiotic [GO:0071236]; cellular response to cold [GO:0070417]; cellular response to electrical stimulus [GO:0071257]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to mechanical stimulus [GO:0071260]; intracellular sodium ion homeostasis [GO:0006883]; maintenance of cell polarity [GO:0030011]; monoatomic ion transport [GO:0006811]; negative regulation of apoptotic process [GO:0043066]; positive regulation of action potential [GO:0045760]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium:sodium antiporter activity [GO:1903281]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell growth [GO:0030307]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of the force of heart contraction [GO:0098735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; potassium ion transmembrane transport [GO:0071805]; protein complex oligomerization [GO:0051259]; proton transmembrane transport [GO:1902600]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of focal adhesion assembly [GO:0051893]; regulation of intracellular pH [GO:0051453]; regulation of pH [GO:0006885]; regulation of stress fiber assembly [GO:0051492]; regulation of the force of heart contraction by cardiac conduction [GO:0086092]; response to acidic pH [GO:0010447]; response to muscle stretch [GO:0035994]; sodium ion export across plasma membrane [GO:0036376]; sodium ion import across plasma membrane [GO:0098719]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:34108458}; Multi-pass membrane protein {ECO:0000269|PubMed:34108458}. Basolateral cell membrane {ECO:0000250|UniProtKB:P48762}; Multi-pass membrane protein {ECO:0000269|PubMed:34108458}. Note=Localized basolaterally in every epithelial cell, except in the choroid plexus where SLC9A1 is expressed luminally. {ECO:0000269|PubMed:19369449}.
P19652	reviewed	A1AG2_HUMAN	Alpha-1-acid glycoprotein 2 (AGP 2) (Orosomucoid-2) (OMD 2)	ORM2 AGP2	Homo sapiens (Human)	201	FUNCTION: Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction. {ECO:0000269|PubMed:21349832}.		acute-phase response [GO:0006953]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of immune system process [GO:0002682]	azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; specific granule lumen [GO:0035580]		azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; specific granule lumen [GO:0035580]; acute-phase response [GO:0006953]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Secreted.
P19784	reviewed	CSK22_HUMAN	Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1)	CSNK2A2 CK2A2	Homo sapiens (Human)	350	FUNCTION: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. {ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064}.	MISCELLANEOUS: Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome.	apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cerebral cortex development [GO:0021987]; liver regeneration [GO:0097421]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of chromosome separation [GO:1905818]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055]	acrosomal vesicle [GO:0001669]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein kinase CK2 complex [GO:0005956]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	acrosomal vesicle [GO:0001669]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein kinase CK2 complex [GO:0005956]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cerebral cortex development [GO:0021987]; liver regeneration [GO:0097421]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of chromosome separation [GO:1905818]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O54833}. Cytoplasm {ECO:0000250|UniProtKB:O54833}. Note=Interaction with SIRT6 prevents translocation into the nucleus. {ECO:0000250|UniProtKB:O54833}.
P19793	reviewed	RXRA_HUMAN	Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)	RXRA NR2B1	Homo sapiens (Human)	462	FUNCTION: Receptor for retinoic acid that acts as a transcription factor (PubMed:11162439, PubMed:11915042). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:28167758, PubMed:17761950, PubMed:16107141, PubMed:18800767, PubMed:19167885). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632). {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:11162439, ECO:0000269|PubMed:11915042, ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:1310260, ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:25417649, ECO:0000269|PubMed:26463675, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:29021580, ECO:0000269|PubMed:30216632, ECO:0000269|PubMed:9267036}.		anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; hormone-mediated signaling pathway [GO:0009755]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of thyroid hormone mediated signaling pathway [GO:0002157]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transporter activity [GO:0032411]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	DNA binding domain binding [GO:0050692]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ion binding [GO:0043167]; LBD domain binding [GO:0050693]; nuclear receptor activity [GO:0004879]; nuclear receptor binding [GO:0016922]; nuclear steroid receptor activity [GO:0003707]; nuclear vitamin D receptor binding [GO:0042809]; peptide binding [GO:0042277]; retinoic acid binding [GO:0001972]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]; DNA binding domain binding [GO:0050692]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ion binding [GO:0043167]; LBD domain binding [GO:0050693]; nuclear receptor activity [GO:0004879]; nuclear receptor binding [GO:0016922]; nuclear steroid receptor activity [GO:0003707]; nuclear vitamin D receptor binding [GO:0042809]; peptide binding [GO:0042277]; retinoic acid binding [GO:0001972]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]; anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; hormone-mediated signaling pathway [GO:0009755]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of thyroid hormone mediated signaling pathway [GO:0002157]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transporter activity [GO:0032411]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:11915042, ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:28167758}. Cytoplasm {ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:15509776}. Mitochondrion {ECO:0000269|PubMed:17761950}. Note=Localization to the nucleus is enhanced by vitamin D3 (PubMed:15509776). Nuclear localization may be enhanced by the interaction with heterodimerization partner VDR (PubMed:12145331). Translocation to the mitochondrion upon interaction with NR4A1 (PubMed:17761950, PubMed:15509776). Increased nuclear localization upon pulsatile shear stress (PubMed:28167758). {ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:28167758}.
P19801	reviewed	AOC1_HUMAN	Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO)	AOC1 ABP1 DAO1	Homo sapiens (Human)	751	FUNCTION: Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.	MISCELLANEOUS: Inhibited by amiloride in a competitive manner. {ECO:0000250}.	amine metabolic process [GO:0009308]; cellular response to azide [GO:0097185]; cellular response to copper ion [GO:0071280]; cellular response to copper ion starvation [GO:0035874]; cellular response to heparin [GO:0071504]; cellular response to histamine [GO:0071420]; putrescine metabolic process [GO:0009445]; response to antibiotic [GO:0046677]	bicellular tight junction [GO:0005923]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]	calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; diamine oxidase activity [GO:0052597]; heparin binding [GO:0008201]; histamine oxidase activity [GO:0052598]; methylputrescine oxidase activity [GO:0052599]; primary amine oxidase activity [GO:0008131]; propane-1,3-diamine oxidase activity [GO:0052600]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; quinone binding [GO:0048038]; zinc ion binding [GO:0008270]	bicellular tight junction [GO:0005923]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; diamine oxidase activity [GO:0052597]; heparin binding [GO:0008201]; histamine oxidase activity [GO:0052598]; methylputrescine oxidase activity [GO:0052599]; primary amine oxidase activity [GO:0008131]; propane-1,3-diamine oxidase activity [GO:0052600]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; quinone binding [GO:0048038]; zinc ion binding [GO:0008270]; amine metabolic process [GO:0009308]; cellular response to azide [GO:0097185]; cellular response to copper ion [GO:0071280]; cellular response to copper ion starvation [GO:0035874]; cellular response to heparin [GO:0071504]; cellular response to histamine [GO:0071420]; putrescine metabolic process [GO:0009445]; response to antibiotic [GO:0046677]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P19823	reviewed	ITIH2_HUMAN	Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP)	ITIH2 IGHEP2	Homo sapiens (Human)	946	FUNCTION: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.		hyaluronan metabolic process [GO:0030212]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	endopeptidase inhibitor activity [GO:0004866]; hyaluronic acid binding [GO:0005540]; serine-type endopeptidase inhibitor activity [GO:0004867]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; endopeptidase inhibitor activity [GO:0004866]; hyaluronic acid binding [GO:0005540]; serine-type endopeptidase inhibitor activity [GO:0004867]; hyaluronan metabolic process [GO:0030212]	SUBCELLULAR LOCATION: Secreted.
P19827	reviewed	ITIH1_HUMAN	Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP)	ITIH1 IGHEP1	Homo sapiens (Human)	911	FUNCTION: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.; FUNCTION: Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.		hyaluronan metabolic process [GO:0030212]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540]; serine-type endopeptidase inhibitor activity [GO:0004867]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540]; serine-type endopeptidase inhibitor activity [GO:0004867]; hyaluronan metabolic process [GO:0030212]	SUBCELLULAR LOCATION: Secreted.
P19835	reviewed	CEL_HUMAN	Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (EC 3.1.1.6) (Bile salt-stimulated lipase) (BSSL) (Bucelipase) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase)	CEL BAL	Homo sapiens (Human)	753	FUNCTION: Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs) (PubMed:8471055, PubMed:27509211, PubMed:10220579, PubMed:27650499). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (PubMed:8471055, PubMed:27509211, PubMed:10220579, PubMed:27650499). {ECO:0000250|UniProtKB:Q64285, ECO:0000269|PubMed:10220579, ECO:0000269|PubMed:27509211, ECO:0000269|PubMed:27650499, ECO:0000269|PubMed:8471055}.		ceramide catabolic process [GO:0046514]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; pancreatic juice secretion [GO:0030157]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	acetylesterase activity [GO:0008126]; catalytic activity [GO:0003824]; heparin binding [GO:0008201]; hydrolase activity [GO:0016787]; retinyl-palmitate esterase activity [GO:0050253]; sterol esterase activity [GO:0004771]; triglyceride lipase activity [GO:0004806]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; acetylesterase activity [GO:0008126]; catalytic activity [GO:0003824]; heparin binding [GO:0008201]; hydrolase activity [GO:0016787]; retinyl-palmitate esterase activity [GO:0050253]; sterol esterase activity [GO:0004771]; triglyceride lipase activity [GO:0004806]; ceramide catabolic process [GO:0046514]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; pancreatic juice secretion [GO:0030157]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21784842}.
P19838	reviewed	NFKB1_HUMAN	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]	NFKB1	Homo sapiens (Human)	968	FUNCTION: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. {ECO:0000269|PubMed:15485931, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:2203531, ECO:0000269|PubMed:2234062, ECO:0000269|PubMed:7830764}.; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B (PubMed:1423592). Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 (PubMed:1423592). {ECO:0000269|PubMed:1423592}.; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor (PubMed:1740106, PubMed:7830764). Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions (PubMed:1740106, PubMed:7830764). {ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:7830764}.		apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to angiotensin [GO:1904385]; cellular response to dsRNA [GO:0071359]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-17 [GO:0097398]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; mammary gland involution [GO:0060056]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of cholesterol transport [GO:0032375]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D biosynthetic process [GO:0010957]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cytokine [GO:0034097]; response to muscle stretch [GO:0035994]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; I-kappaB/NF-kappaB complex [GO:0033256]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]	actinin binding [GO:0042805]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; I-kappaB/NF-kappaB complex [GO:0033256]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; actinin binding [GO:0042805]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator activity [GO:0003712]; apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to angiotensin [GO:1904385]; cellular response to dsRNA [GO:0071359]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-17 [GO:0097398]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; mammary gland involution [GO:0060056]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of cholesterol transport [GO:0032375]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D biosynthetic process [GO:0010957]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cytokine [GO:0034097]; response to muscle stretch [GO:0035994]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: [Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm {ECO:0000269|PubMed:1423592}.; SUBCELLULAR LOCATION: [Nuclear factor NF-kappa-B p50 subunit]: Nucleus {ECO:0000269|PubMed:9865693}. Cytoplasm {ECO:0000269|PubMed:9865693}. Note=Association with NFKBIA inhibitor (I-kappa-B), promotes its retention in the cytoplasm in an inactive form (PubMed:9865693). Translocates into the nucleus following NFKBIA degradation (PubMed:9865693). {ECO:0000269|PubMed:9865693}.
P19875	reviewed	CXCL2_HUMAN	C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]	CXCL2 GRO2 GROB MIP2A SCYB2	Homo sapiens (Human)	107	FUNCTION: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. {ECO:0000269|PubMed:10725737}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; response to molecule of bacterial origin [GO:0002237]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; response to molecule of bacterial origin [GO:0002237]	SUBCELLULAR LOCATION: Secreted.
P19876	reviewed	CXCL3_HUMAN	C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)]	CXCL3 GRO3 GROG SCYB3	Homo sapiens (Human)	107	FUNCTION: Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. {ECO:0000250, ECO:0000269|PubMed:10095777}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]	SUBCELLULAR LOCATION: Secreted.
P19878	reviewed	NCF2_HUMAN	Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox)	NCF2 NOXA2 P67PHOX	Homo sapiens (Human)	526	FUNCTION: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000269|PubMed:12207919}.		cellular defense response [GO:0006968]; innate immune response [GO:0045087]; phagocytosis [GO:0006909]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]	electron transfer activity [GO:0009055]; small GTPase binding [GO:0031267]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activator activity [GO:0016176]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; small GTPase binding [GO:0031267]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; cellular defense response [GO:0006968]; innate immune response [GO:0045087]; phagocytosis [GO:0006909]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Cytoplasm.
P19883	reviewed	FST_HUMAN	Follistatin (FS) (Activin-binding protein)	FST	Homo sapiens (Human)	344	FUNCTION: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).		ameloblast differentiation [GO:0036305]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; female gonad development [GO:0008585]; gamete generation [GO:0007276]; hair follicle morphogenesis [GO:0031069]; hematopoietic progenitor cell differentiation [GO:0002244]; keratinocyte proliferation [GO:0043616]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis of dentin-containing tooth [GO:0042475]; pattern specification process [GO:0007389]; positive regulation of hair follicle development [GO:0051798]; regulation of BMP signaling pathway [GO:0030510]; response to organic cyclic compound [GO:0014070]; skeletal system development [GO:0001501]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]	activin binding [GO:0048185]; activin receptor antagonist activity [GO:0038102]; heparan sulfate proteoglycan binding [GO:0043395]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; activin binding [GO:0048185]; activin receptor antagonist activity [GO:0038102]; heparan sulfate proteoglycan binding [GO:0043395]; ameloblast differentiation [GO:0036305]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; female gonad development [GO:0008585]; gamete generation [GO:0007276]; hair follicle morphogenesis [GO:0031069]; hematopoietic progenitor cell differentiation [GO:0002244]; keratinocyte proliferation [GO:0043616]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis of dentin-containing tooth [GO:0042475]; pattern specification process [GO:0007389]; positive regulation of hair follicle development [GO:0051798]; regulation of BMP signaling pathway [GO:0030510]; response to organic cyclic compound [GO:0014070]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted.
P19957	reviewed	ELAF_HUMAN	Elafin (Elastase-specific inhibitor) (ESI) (Peptidase inhibitor 3) (PI-3) (Protease inhibitor WAP3) (Skin-derived antileukoproteinase) (SKALP) (WAP four-disulfide core domain protein 14)	PI3 WAP3 WFDC14	Homo sapiens (Human)	117	FUNCTION: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648). {ECO:0000269|PubMed:29483648}.		antibacterial humoral response [GO:0019731]; copulation [GO:0007620]; innate immune response [GO:0045087]; peptide cross-linking [GO:0018149]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; structural constituent of skin epidermis [GO:0030280]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; structural constituent of skin epidermis [GO:0030280]; antibacterial humoral response [GO:0019731]; copulation [GO:0007620]; innate immune response [GO:0045087]; peptide cross-linking [GO:0018149]	SUBCELLULAR LOCATION: Secreted.
P19971	reviewed	TYPH_HUMAN	Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase)	TYMP ECGF1	Homo sapiens (Human)	482	FUNCTION: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269|PubMed:1590793}.; FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:1590793}.		angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; dTMP catabolic process [GO:0046074]; mitochondrial genome maintenance [GO:0000002]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]; regulation of gastric motility [GO:1905333]; regulation of myelination [GO:0031641]; regulation of transmission of nerve impulse [GO:0051969]	cytosol [GO:0005829]	1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; pyrimidine-nucleoside phosphorylase activity [GO:0016154]; thymidine phosphorylase activity [GO:0009032]	cytosol [GO:0005829]; 1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; pyrimidine-nucleoside phosphorylase activity [GO:0016154]; thymidine phosphorylase activity [GO:0009032]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; dTMP catabolic process [GO:0046074]; mitochondrial genome maintenance [GO:0000002]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]; regulation of gastric motility [GO:1905333]; regulation of myelination [GO:0031641]; regulation of transmission of nerve impulse [GO:0051969]	
P20020	reviewed	AT2B1_HUMAN	Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1)	ATP2B1 PMCA1	Homo sapiens (Human)	1220	FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:35358416). Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles. {ECO:0000250|UniProtKB:G5E829, ECO:0000269|PubMed:29104511, ECO:0000269|PubMed:35358416}.		calcium ion export across plasma membrane [GO:1990034]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport [GO:0051928]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of vascular associated smooth muscle contraction [GO:0003056]	basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165]	basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165]; calcium ion export across plasma membrane [GO:1990034]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport [GO:0051928]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of vascular associated smooth muscle contraction [GO:0003056]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18029012, ECO:0000269|PubMed:35358416}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:G5E829}. Synapse {ECO:0000250|UniProtKB:G5E829}. Presynaptic cell membrane {ECO:0000250|UniProtKB:G5E829}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:G5E829}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with SV2A in photoreceptor synaptic terminals. Colocalizes with NPTN to the immunological synapse. Colocalizes with EPB41 to the basolateral membrane in enterocyte. Preferentially sorted to recycling synaptic vesicles. {ECO:0000250|UniProtKB:G5E829}.
P20023	reviewed	CR2_HUMAN	Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21)	CR2 C3DR	Homo sapiens (Human)	1033	FUNCTION: Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes activation (PubMed:7753047). {ECO:0000269|PubMed:7753047}.; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus. {ECO:0000269|PubMed:2460635}.		B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; negative regulation of complement activation, classical pathway [GO:0045959]; T cell mediated immunity [GO:0002456]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	complement binding [GO:0001848]; complement receptor activity [GO:0004875]; DNA binding [GO:0003677]; immunoglobulin receptor binding [GO:0034987]; protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; complement binding [GO:0001848]; complement receptor activity [GO:0004875]; DNA binding [GO:0003677]; immunoglobulin receptor binding [GO:0034987]; protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; negative regulation of complement activation, classical pathway [GO:0045959]; T cell mediated immunity [GO:0002456]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:1702139}; Single-pass type I membrane protein.
P20036	reviewed	DPA1_HUMAN	HLA class II histocompatibility antigen, DP alpha 1 chain (DP(W3)) (DP(W4)) (HLA-SB alpha chain) (MHC class II DP3-alpha) (MHC class II DPA1)	HLA-DPA1 HLA-DP1A HLASB	Homo sapiens (Human)	260	FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cellular response to type II interferon [GO:0071346]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]	MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cellular response to type II interferon [GO:0071346]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
P20042	reviewed	IF2B_HUMAN	Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta)	EIF2S2 EIF2B	Homo sapiens (Human)	333	FUNCTION: Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. {ECO:0000250|UniProtKB:P05198}.		formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; in utero embryonic development [GO:0001701]; male germ cell proliferation [GO:0002176]; male gonad development [GO:0008584]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2 complex [GO:0005850]; synapse [GO:0045202]	metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2 complex [GO:0005850]; synapse [GO:0045202]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]; formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; in utero embryonic development [GO:0001701]; male germ cell proliferation [GO:0002176]; male gonad development [GO:0008584]; translational initiation [GO:0006413]	
P20061	reviewed	TCO1_HUMAN	Transcobalamin-1 (TC-1) (Haptocorrin) (HC) (Protein R) (Transcobalamin I) (TC I) (TCI)	TCN1 TC1	Homo sapiens (Human)	433	FUNCTION: Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.		cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	cobalamin binding [GO:0031419]; molecular sequestering activity [GO:0140313]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; cobalamin binding [GO:0031419]; molecular sequestering activity [GO:0140313]; cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824]	SUBCELLULAR LOCATION: Secreted.
P20062	reviewed	TCO2_HUMAN	Transcobalamin-2 (TC-2) (Transcobalamin II) (TC II) (TCII)	TCN2 TC2	Homo sapiens (Human)	427	FUNCTION: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. {ECO:0000269|PubMed:8443384}.		cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]	cargo receptor ligand activity [GO:0140355]; cobalamin binding [GO:0031419]; metal ion binding [GO:0046872]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; cargo receptor ligand activity [GO:0140355]; cobalamin binding [GO:0031419]; metal ion binding [GO:0046872]; cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3782074, ECO:0000269|PubMed:8443384}.
P20073	reviewed	ANXA7_HUMAN	Annexin A7 (Annexin VII) (Annexin-7) (Synexin)	ANXA7 ANX7 SNX OK/SW-cl.95	Homo sapiens (Human)	488	FUNCTION: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.		autophagy [GO:0006914]; epithelial cell differentiation [GO:0030855]; negative regulation of gene expression [GO:0010629]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; integrin binding [GO:0005178]; RNA binding [GO:0003723]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; integrin binding [GO:0005178]; RNA binding [GO:0003723]; autophagy [GO:0006914]; epithelial cell differentiation [GO:0030855]; negative regulation of gene expression [GO:0010629]	
P20132	reviewed	SDHL_HUMAN	L-serine dehydratase/L-threonine deaminase (SDH) (EC 4.3.1.17) (L-serine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19)	SDS SDH	Homo sapiens (Human)	328			gluconeogenesis [GO:0006094]; isoleucine biosynthetic process [GO:0009097]; L-serine catabolic process [GO:0006565]; lipid metabolic process [GO:0006629]; pyruvate biosynthetic process [GO:0042866]; threonine catabolic process [GO:0006567]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	L-serine ammonia-lyase activity [GO:0003941]; L-threonine ammonia-lyase activity [GO:0004794]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; L-serine ammonia-lyase activity [GO:0003941]; L-threonine ammonia-lyase activity [GO:0004794]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; gluconeogenesis [GO:0006094]; isoleucine biosynthetic process [GO:0009097]; L-serine catabolic process [GO:0006565]; lipid metabolic process [GO:0006629]; pyruvate biosynthetic process [GO:0042866]; threonine catabolic process [GO:0006567]	SUBCELLULAR LOCATION: Cytoplasm.
P20138	reviewed	CD33_HUMAN	Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33)	CD33 SIGLEC3	Homo sapiens (Human)	364	FUNCTION: Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323). {ECO:0000269|PubMed:10206955, ECO:0000269|PubMed:10556798, ECO:0000269|PubMed:10611343, ECO:0000269|PubMed:10887109, ECO:0000269|PubMed:11320212, ECO:0000269|PubMed:15597323, ECO:0000269|PubMed:28325905, ECO:0000269|PubMed:7718872}.	MISCELLANEOUS: [Isoform CD33m]: Mostly detected on NKL and myeloid cell lines but poorly expressed on B-cell lines and T-lymphocytes. {ECO:0000305}.	cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; immune response-inhibiting signal transduction [GO:0002765]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of monocyte activation [GO:0150102]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of protein secretion [GO:0050714]; positive regulation of protein tyrosine phosphatase activity [GO:1903615]; signal transduction [GO:0007165]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	carbohydrate binding [GO:0030246]; protein phosphatase binding [GO:0019903]; sialic acid binding [GO:0033691]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; carbohydrate binding [GO:0030246]; protein phosphatase binding [GO:0019903]; sialic acid binding [GO:0033691]; signaling receptor activity [GO:0038023]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; immune response-inhibiting signal transduction [GO:0002765]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of monocyte activation [GO:0150102]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of protein secretion [GO:0050714]; positive regulation of protein tyrosine phosphatase activity [GO:1903615]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform CD33M]: Cell membrane {ECO:0000269|PubMed:10611343, ECO:0000269|PubMed:28747436}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform CD33m]: Peroxisome {ECO:0000269|PubMed:28747436}. Note=CD33m isoform does not localize to cell surfaces but instead accumulates in peroxisomes. {ECO:0000269|PubMed:28747436}.
P20142	reviewed	PEPC_HUMAN	Gastricsin (EC 3.4.23.3) (Pepsinogen C)	PGC	Homo sapiens (Human)	388	FUNCTION: Hydrolyzes a variety of proteins.		digestion [GO:0007586]; positive regulation of antibacterial peptide production [GO:0002803]; proteolysis [GO:0006508]	extracellular space [GO:0005615]	aspartic-type endopeptidase activity [GO:0004190]	extracellular space [GO:0005615]; aspartic-type endopeptidase activity [GO:0004190]; digestion [GO:0007586]; positive regulation of antibacterial peptide production [GO:0002803]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
P20151	reviewed	KLK2_HUMAN	Kallikrein-2 (EC 3.4.21.35) (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2)	KLK2	Homo sapiens (Human)	261	FUNCTION: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; secretory granule [GO:0030141]	serine-type endopeptidase activity [GO:0004252]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	
P20155	reviewed	ISK2_HUMAN	Serine protease inhibitor Kazal-type 2 (Acrosin-trypsin inhibitor) (Epididymis tissue protein Li 172) (HUSI-II)	SPINK2	Homo sapiens (Human)	84	FUNCTION: As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin. {ECO:0000250|UniProtKB:Q8BMY7, ECO:0000269|PubMed:19422058, ECO:0000269|PubMed:28554943}.		acrosome assembly [GO:0001675]; spermatid development [GO:0007286]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]	endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; acrosome assembly [GO:0001675]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:28554943}.
P20160	reviewed	CAP7_HUMAN	Azurocidin (Cationic antimicrobial protein CAP37) (Heparin-binding protein) (HBP) (hHBP)	AZU1	Homo sapiens (Human)	251	FUNCTION: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G. {ECO:0000269|PubMed:1399008, ECO:0000269|PubMed:1937776, ECO:0000269|PubMed:2312733}.		antimicrobial humoral response [GO:0019730]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell chemotaxis [GO:0060326]; cellular extravasation [GO:0045123]; defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; glial cell migration [GO:0008347]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; macrophage chemotaxis [GO:0048246]; microglial cell activation [GO:0001774]; monocyte activation [GO:0042117]; negative regulation of apoptotic process [GO:0043066]; neutrophil-mediated killing of bacterium [GO:0070944]; positive regulation of cell adhesion [GO:0045785]; positive regulation of fractalkine production [GO:0032724]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of tumor necrosis factor production [GO:0032760]; protein kinase C signaling [GO:0070528]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; proteolysis [GO:0006508]; regulation of vascular permeability [GO:0043114]	azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; toxic substance binding [GO:0015643]	azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; toxic substance binding [GO:0015643]; antimicrobial humoral response [GO:0019730]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell chemotaxis [GO:0060326]; cellular extravasation [GO:0045123]; defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; glial cell migration [GO:0008347]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; macrophage chemotaxis [GO:0048246]; microglial cell activation [GO:0001774]; monocyte activation [GO:0042117]; negative regulation of apoptotic process [GO:0043066]; neutrophil-mediated killing of bacterium [GO:0070944]; positive regulation of cell adhesion [GO:0045785]; positive regulation of fractalkine production [GO:0032724]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of tumor necrosis factor production [GO:0032760]; protein kinase C signaling [GO:0070528]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; proteolysis [GO:0006508]; regulation of vascular permeability [GO:0043114]	SUBCELLULAR LOCATION: Cytoplasmic granule membrane {ECO:0000269|PubMed:2312733, ECO:0000269|PubMed:2501794}; Peripheral membrane protein {ECO:0000269|PubMed:2312733}; Cytoplasmic side {ECO:0000269|PubMed:2312733}. Note=Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides. {ECO:0000269|PubMed:2312733, ECO:0000269|PubMed:2501794}.
P20226	reviewed	TBP_HUMAN	TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)	TBP GTF2D1 TF2D TFIID	Homo sapiens (Human)	339	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473, PubMed:27193682, PubMed:2194289, PubMed:2363050, PubMed:2374612). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:27007846). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TBP forms the TFIID-A module together with TAF3 and TAF5 (PubMed:33795473). TBP is a general transcription factor that functions at the core of the TFIID complex (PubMed:33795473, PubMed:27193682, PubMed:2194289, PubMed:2363050, PubMed:2374612, PubMed:9836642). During assembly of the core PIC on the promoter, as part of TFIID, TBP binds to and also bends promoter DNA, irrespective of whether the promoter contains a TATA box (PubMed:33795473). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter (PubMed:15970593). SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA (PubMed:15970593). {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:2194289, ECO:0000269|PubMed:2363050, ECO:0000269|PubMed:2374612, ECO:0000269|PubMed:26638071, ECO:0000269|PubMed:27007846, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:9836642}.		DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase II promoter [GO:0006367]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; female germ cell nucleus [GO:0001674]; female pronucleus [GO:0001939]; male germ cell nucleus [GO:0001673]; male pronucleus [GO:0001940]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase transcription factor SL1 complex [GO:0005668]; transcription factor TFIIA complex [GO:0005672]; transcription factor TFIID complex [GO:0005669]	aryl hydrocarbon receptor binding [GO:0017162]; core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; TFIIB-class transcription factor binding [GO:0001093]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; female germ cell nucleus [GO:0001674]; female pronucleus [GO:0001939]; male germ cell nucleus [GO:0001673]; male pronucleus [GO:0001940]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase transcription factor SL1 complex [GO:0005668]; transcription factor TFIIA complex [GO:0005672]; transcription factor TFIID complex [GO:0005669]; aryl hydrocarbon receptor binding [GO:0017162]; core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; TFIIB-class transcription factor binding [GO:0001093]; transcription cis-regulatory region binding [GO:0000976]; DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27007846}.
P20231	reviewed	TRYB2_HUMAN	Tryptase beta-2 (Tryptase-2) (EC 3.4.21.59) (Tryptase II)	TPSB2 TPS2	Homo sapiens (Human)	275	FUNCTION: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. {ECO:0000250, ECO:0000250|UniProtKB:P21845}.		proteolysis [GO:0006508]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted. Note=Released from the secretory granules upon mast cell activation.
P20248	reviewed	CCNA2_HUMAN	Cyclin-A2 (Cyclin-A) (Cyclin A)	CCNA2 CCN1 CCNA	Homo sapiens (Human)	432	FUNCTION: Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. {ECO:0000269|PubMed:1312467}.		animal organ regeneration [GO:0031100]; cell cycle G1/S phase transition [GO:0044843]; cell division [GO:0051301]; cellular response to cocaine [GO:0071314]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hypoxia [GO:0071456]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to leptin stimulus [GO:0044320]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to nitric oxide [GO:0071732]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cochlea development [GO:0090102]; DNA-templated transcription [GO:0006351]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle phase transition [GO:0044772]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; post-translational protein modification [GO:0043687]; Ras protein signal transduction [GO:0007265]; regulation of DNA replication [GO:0006275]; response to glucagon [GO:0033762]	cyclin A2-CDK1 complex [GO:0097122]; cyclin A2-CDK2 complex [GO:0097124]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]	cyclin A2-CDK1 complex [GO:0097122]; cyclin A2-CDK2 complex [GO:0097124]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; animal organ regeneration [GO:0031100]; cell cycle G1/S phase transition [GO:0044843]; cell division [GO:0051301]; cellular response to cocaine [GO:0071314]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hypoxia [GO:0071456]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to leptin stimulus [GO:0044320]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to nitric oxide [GO:0071732]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cochlea development [GO:0090102]; DNA-templated transcription [GO:0006351]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle phase transition [GO:0044772]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; post-translational protein modification [GO:0043687]; Ras protein signal transduction [GO:0007265]; regulation of DNA replication [GO:0006275]; response to glucagon [GO:0033762]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606}. Cytoplasm {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606}. Note=Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606). {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606}.
P20264	reviewed	PO3F3_HUMAN	POU domain, class 3, transcription factor 3 (Brain-specific homeobox/POU domain protein 1) (Brain-1) (Brn-1) (Octamer-binding protein 8) (Oct-8) (Octamer-binding transcription factor 8) (OTF-8)	POU3F3 BRN1 OTF8	Homo sapiens (Human)	500	FUNCTION: Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development (PubMed:31303265). Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity). {ECO:0000250|UniProtKB:P31361, ECO:0000250|UniProtKB:Q63262, ECO:0000269|PubMed:31303265}.		central nervous system development [GO:0007417]; cerebral cortex radially oriented cell migration [GO:0021799]; chemical homeostasis [GO:0048878]; forebrain ventricular zone progenitor cell division [GO:0021869]; metanephric ascending thin limb development [GO:0072218]; metanephric DCT cell differentiation [GO:0072240]; metanephric loop of Henle development [GO:0072236]; metanephric macula densa development [GO:0072227]; metanephric thick ascending limb development [GO:0072233]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; urea transmembrane transport [GO:0071918]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; central nervous system development [GO:0007417]; cerebral cortex radially oriented cell migration [GO:0021799]; chemical homeostasis [GO:0048878]; forebrain ventricular zone progenitor cell division [GO:0021869]; metanephric ascending thin limb development [GO:0072218]; metanephric DCT cell differentiation [GO:0072240]; metanephric loop of Henle development [GO:0072236]; metanephric macula densa development [GO:0072227]; metanephric thick ascending limb development [GO:0072233]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; urea transmembrane transport [GO:0071918]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31303265}.
P20265	reviewed	PO3F2_HUMAN	POU domain, class 3, transcription factor 2 (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Brn-2) (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Octamer-binding protein 7) (Oct-7) (Octamer-binding transcription factor 7) (OTF-7)	POU3F2 BRN2 OCT7 OTF7	Homo sapiens (Human)	443	FUNCTION: Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). {ECO:0000250|UniProtKB:P31360, ECO:0000250|UniProtKB:P56222}.		cellular response to organic substance [GO:0071310]; cerebral cortex radially oriented cell migration [GO:0021799]; epidermis development [GO:0008544]; forebrain astrocyte development [GO:0021897]; forebrain ventricular zone progenitor cell division [GO:0021869]; hypothalamus cell differentiation [GO:0021979]; myelination in peripheral nervous system [GO:0022011]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; neuroendocrine cell differentiation [GO:0061101]; neurohypophysis development [GO:0021985]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of axonogenesis [GO:0050770]; regulation of cell differentiation [GO:0045595]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to organic substance [GO:0071310]; cerebral cortex radially oriented cell migration [GO:0021799]; epidermis development [GO:0008544]; forebrain astrocyte development [GO:0021897]; forebrain ventricular zone progenitor cell division [GO:0021869]; hypothalamus cell differentiation [GO:0021979]; myelination in peripheral nervous system [GO:0022011]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; neuroendocrine cell differentiation [GO:0061101]; neurohypophysis development [GO:0021985]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of axonogenesis [GO:0050770]; regulation of cell differentiation [GO:0045595]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P20273	reviewed	CD22_HUMAN	B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)	CD22 SIGLEC2	Homo sapiens (Human)	847	FUNCTION: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.		B cell activation [GO:0042113]; cell adhesion [GO:0007155]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of calcium-mediated signaling [GO:0050849]; negative regulation of immunoglobulin production [GO:0002638]; regulation of B cell proliferation [GO:0030888]; regulation of endocytosis [GO:0030100]; regulation of immune response [GO:0050776]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	carbohydrate binding [GO:0030246]; CD4 receptor binding [GO:0042609]; IgM binding [GO:0001791]; protein phosphatase binding [GO:0019903]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; carbohydrate binding [GO:0030246]; CD4 receptor binding [GO:0042609]; IgM binding [GO:0001791]; protein phosphatase binding [GO:0019903]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]; B cell activation [GO:0042113]; cell adhesion [GO:0007155]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of calcium-mediated signaling [GO:0050849]; negative regulation of immunoglobulin production [GO:0002638]; regulation of B cell proliferation [GO:0030888]; regulation of endocytosis [GO:0030100]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P20290	reviewed	BTF3_HUMAN	Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3)	BTF3 NACB OK/SW-cl.8	Homo sapiens (Human)	206	FUNCTION: When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}.		negative regulation of protein localization to endoplasmic reticulum [GO:1905551]; protein transport [GO:0015031]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; RNA binding [GO:0003723]; negative regulation of protein localization to endoplasmic reticulum [GO:1905551]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10982809}. Nucleus {ECO:0000269|PubMed:10982809}. Note=The heterodimer with NACA is cytoplasmic.
P20292	reviewed	AL5AP_HUMAN	Arachidonate 5-lipoxygenase-activating protein (FLAP) (MK-886-binding protein)	ALOX5AP FLAP	Homo sapiens (Human)	161	FUNCTION: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {ECO:0000269|PubMed:2300173, ECO:0000269|PubMed:8440384}.		cellular response to calcium ion [GO:0071277]; leukotriene biosynthetic process [GO:0019370]; leukotriene production involved in inflammatory response [GO:0002540]; lipoxygenase pathway [GO:0019372]; positive regulation of acute inflammatory response [GO:0002675]; protein homotrimerization [GO:0070207]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]	arachidonate 5-lipoxygenase activity [GO:0004051]; arachidonic acid binding [GO:0050544]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464]; protein-containing complex binding [GO:0044877]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; arachidonate 5-lipoxygenase activity [GO:0004051]; arachidonic acid binding [GO:0050544]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464]; protein-containing complex binding [GO:0044877]; cellular response to calcium ion [GO:0071277]; leukotriene biosynthetic process [GO:0019370]; leukotriene production involved in inflammatory response [GO:0002540]; lipoxygenase pathway [GO:0019372]; positive regulation of acute inflammatory response [GO:0002675]; protein homotrimerization [GO:0070207]	SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
P20309	reviewed	ACM3_HUMAN	Muscarinic acetylcholine receptor M3	CHRM3	Homo sapiens (Human)	590	FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:7565628}.		acetylcholine receptor signaling pathway [GO:0095500]; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; calcium-mediated signaling [GO:0019722]; chemical synaptic transmission [GO:0007268]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; nervous system development [GO:0007399]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of insulin secretion [GO:0032024]; positive regulation of smooth muscle contraction [GO:0045987]; protein modification process [GO:0036211]; regulation of monoatomic ion transmembrane transporter activity [GO:0032412]; regulation of vascular associated smooth muscle contraction [GO:0003056]; saliva secretion [GO:0046541]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	acetylcholine binding [GO:0042166]; G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; phosphatidylinositol phospholipase C activity [GO:0004435]; signaling receptor activity [GO:0038023]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; acetylcholine binding [GO:0042166]; G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; phosphatidylinositol phospholipase C activity [GO:0004435]; signaling receptor activity [GO:0038023]; acetylcholine receptor signaling pathway [GO:0095500]; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; calcium-mediated signaling [GO:0019722]; chemical synaptic transmission [GO:0007268]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; nervous system development [GO:0007399]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of insulin secretion [GO:0032024]; positive regulation of smooth muscle contraction [GO:0045987]; protein modification process [GO:0036211]; regulation of monoatomic ion transmembrane transporter activity [GO:0032412]; regulation of vascular associated smooth muscle contraction [GO:0003056]; saliva secretion [GO:0046541]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21056967}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15870063}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21056967}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane. {ECO:0000269|PubMed:21056967}.
P20333	reviewed	TNR1B_HUMAN	Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]	TNFRSF1B TNFBR TNFR2	Homo sapiens (Human)	461	FUNCTION: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. {ECO:0000269|PubMed:12370298}.		aortic valve development [GO:0003176]; cellular response to growth factor stimulus [GO:0071363]; cellular response to lipopolysaccharide [GO:0071222]; extrinsic apoptotic signaling pathway [GO:0097191]; glial cell-neuron signaling [GO:0150098]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of neuroinflammatory response [GO:0150079]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; pulmonary valve development [GO:0003177]; regulation of cytokine production involved in immune response [GO:0002718]; regulation of myelination [GO:0031641]; regulation of neuroinflammatory response [GO:0150077]; regulation of T cell cytokine production [GO:0002724]; regulation of T cell proliferation [GO:0042129]; RNA destabilization [GO:0050779]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	extracellular region [GO:0005576]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tumor necrosis factor receptor superfamily complex [GO:0002947]; varicosity [GO:0043196]	tumor necrosis factor binding [GO:0043120]; tumor necrosis factor receptor activity [GO:0005031]; ubiquitin protein ligase binding [GO:0031625]	extracellular region [GO:0005576]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tumor necrosis factor receptor superfamily complex [GO:0002947]; varicosity [GO:0043196]; tumor necrosis factor binding [GO:0043120]; tumor necrosis factor receptor activity [GO:0005031]; ubiquitin protein ligase binding [GO:0031625]; aortic valve development [GO:0003176]; cellular response to growth factor stimulus [GO:0071363]; cellular response to lipopolysaccharide [GO:0071222]; extrinsic apoptotic signaling pathway [GO:0097191]; glial cell-neuron signaling [GO:0150098]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of neuroinflammatory response [GO:0150079]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; pulmonary valve development [GO:0003177]; regulation of cytokine production involved in immune response [GO:0002718]; regulation of myelination [GO:0031641]; regulation of neuroinflammatory response [GO:0150077]; regulation of T cell cytokine production [GO:0002724]; regulation of T cell proliferation [GO:0042129]; RNA destabilization [GO:0050779]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Tumor necrosis factor-binding protein 2]: Secreted.
P20336	reviewed	RAB3A_HUMAN	Ras-related protein Rab-3A	RAB3A	Homo sapiens (Human)	220	FUNCTION: Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMed:30599141). Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity). {ECO:0000250|UniProtKB:P63011, ECO:0000250|UniProtKB:P63012, ECO:0000269|PubMed:22248876, ECO:0000269|PubMed:27325790, ECO:0000269|PubMed:30599141}.		acrosomal vesicle exocytosis [GO:0060478]; axonogenesis [GO:0007409]; calcium-ion regulated exocytosis [GO:0017156]; constitutive secretory pathway [GO:0045054]; evoked neurotransmitter secretion [GO:0061670]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]; lung development [GO:0030324]; lysosome localization [GO:0032418]; maintenance of presynaptic active zone structure [GO:0048790]; mitochondrion organization [GO:0007005]; neuromuscular synaptic transmission [GO:0007274]; plasma membrane repair [GO:0001778]; positive regulation of exocytosis [GO:0045921]; positive regulation of regulated secretory pathway [GO:1903307]; post-embryonic development [GO:0009791]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulated exocytosis [GO:0045055]; regulation of exocytosis [GO:0017157]; regulation of plasma membrane repair [GO:1905684]; regulation of presynaptic dense core granule exocytosis [GO:0099161]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; respiratory system process [GO:0003016]; response to electrical stimulus [GO:0051602]; sensory perception of touch [GO:0050975]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle recycling [GO:0036465]; synaptic vesicle transport [GO:0048489]; vesicle docking involved in exocytosis [GO:0006904]	acrosomal vesicle [GO:0001669]; axon [GO:0030424]; clathrin-sculpted acetylcholine transport vesicle membrane [GO:0060201]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular vesicle [GO:1903561]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; secretory granule membrane [GO:0030667]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein-macromolecule adaptor activity [GO:0030674]	acrosomal vesicle [GO:0001669]; axon [GO:0030424]; clathrin-sculpted acetylcholine transport vesicle membrane [GO:0060201]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular vesicle [GO:1903561]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; secretory granule membrane [GO:0030667]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein-macromolecule adaptor activity [GO:0030674]; acrosomal vesicle exocytosis [GO:0060478]; axonogenesis [GO:0007409]; calcium-ion regulated exocytosis [GO:0017156]; constitutive secretory pathway [GO:0045054]; evoked neurotransmitter secretion [GO:0061670]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]; lung development [GO:0030324]; lysosome localization [GO:0032418]; maintenance of presynaptic active zone structure [GO:0048790]; mitochondrion organization [GO:0007005]; neuromuscular synaptic transmission [GO:0007274]; plasma membrane repair [GO:0001778]; positive regulation of exocytosis [GO:0045921]; positive regulation of regulated secretory pathway [GO:1903307]; post-embryonic development [GO:0009791]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulated exocytosis [GO:0045055]; regulation of exocytosis [GO:0017157]; regulation of plasma membrane repair [GO:1905684]; regulation of presynaptic dense core granule exocytosis [GO:0099161]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; respiratory system process [GO:0003016]; response to electrical stimulus [GO:0051602]; sensory perception of touch [GO:0050975]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle recycling [GO:0036465]; synaptic vesicle transport [GO:0048489]; vesicle docking involved in exocytosis [GO:0006904]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P63012}. Lysosome {ECO:0000269|PubMed:27325790}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P63012}. Cell projection, axon {ECO:0000250|UniProtKB:P63011}. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Presynapse {ECO:0000250|UniProtKB:P63011}. Postsynapse {ECO:0000250|UniProtKB:P63011}. Note=Cycles between a vesicle-associated GTP-bound form and a cytosolic GDP-bound form. {ECO:0000250|UniProtKB:P63012}.
P20337	reviewed	RAB3B_HUMAN	Ras-related protein Rab-3B	RAB3B	Homo sapiens (Human)	219	FUNCTION: Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250}.		antigen processing and presentation [GO:0019882]; positive regulation of dopamine uptake involved in synaptic transmission [GO:0051586]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of vesicle size [GO:0097494]; vesicle docking involved in exocytosis [GO:0006904]	cytoplasm [GO:0005737]; dopaminergic synapse [GO:0098691]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]	cytoplasm [GO:0005737]; dopaminergic synapse [GO:0098691]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; antigen processing and presentation [GO:0019882]; positive regulation of dopamine uptake involved in synaptic transmission [GO:0051586]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of vesicle size [GO:0097494]; vesicle docking involved in exocytosis [GO:0006904]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q9CZT8}. Note=Colocalizes with GAS8/DRC4 in the Golgi apparatus. {ECO:0000250|UniProtKB:Q9CZT8}.
P20338	reviewed	RAB4A_HUMAN	Ras-related protein Rab-4A (EC 3.6.5.2)	RAB4A RAB4	Homo sapiens (Human)	218	FUNCTION: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:15907487, PubMed:16034420). Involved in protein transport (PubMed:29425100). Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). {ECO:0000250|UniProtKB:P56371, ECO:0000269|PubMed:15907487, ECO:0000269|PubMed:16034420, ECO:0000269|PubMed:29425100}.		antigen processing and presentation [GO:0019882]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192]	cytoplasmic vesicle membrane [GO:0030659]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; insulin-responsive compartment [GO:0032593]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic recycling endosome [GO:0098837]; recycling endosome membrane [GO:0055038]; vesicle [GO:0031982]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasmic vesicle membrane [GO:0030659]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; insulin-responsive compartment [GO:0032593]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic recycling endosome [GO:0098837]; recycling endosome membrane [GO:0055038]; vesicle [GO:0031982]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; antigen processing and presentation [GO:0019882]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein {ECO:0000269|PubMed:1425574}. Cytoplasm {ECO:0000269|PubMed:1425574}. Early endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. {ECO:0000269|PubMed:1425574}.
P20339	reviewed	RAB5A_HUMAN	Ras-related protein Rab-5A (EC 3.6.5.2)	RAB5A RAB5	Homo sapiens (Human)	215	FUNCTION: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). {ECO:0000250|UniProtKB:Q9CQD1, ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077, ECO:0000269|PubMed:22660413}.		amyloid-beta clearance by transcytosis [GO:0150093]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; modulation by host of viral process [GO:0044788]; phagocytosis [GO:0006909]; positive regulation of exocytosis [GO:0045921]; receptor internalization involved in canonical Wnt signaling pathway [GO:2000286]; regulation of autophagosome assembly [GO:2000785]; regulation of endosome size [GO:0051036]; regulation of filopodium assembly [GO:0051489]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle recycling [GO:0036465]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon terminus [GO:0043679]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytoplasmic side of early endosome membrane [GO:0098559]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endomembrane system [GO:0012505]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic early endosome [GO:0098842]; ruffle [GO:0001726]; somatodendritic compartment [GO:0036477]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon terminus [GO:0043679]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytoplasmic side of early endosome membrane [GO:0098559]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endomembrane system [GO:0012505]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic early endosome [GO:0098842]; ruffle [GO:0001726]; somatodendritic compartment [GO:0036477]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; amyloid-beta clearance by transcytosis [GO:0150093]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; modulation by host of viral process [GO:0044788]; phagocytosis [GO:0006909]; positive regulation of exocytosis [GO:0045921]; receptor internalization involved in canonical Wnt signaling pathway [GO:2000286]; regulation of autophagosome assembly [GO:2000785]; regulation of endosome size [GO:0051036]; regulation of filopodium assembly [GO:0051489]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle recycling [GO:0036465]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23815289}; Lipid-anchor {ECO:0000305|PubMed:7991565}; Cytoplasmic side {ECO:0000269|PubMed:23382462}. Early endosome membrane {ECO:0000269|PubMed:23815289, ECO:0000269|PubMed:25869668}; Lipid-anchor {ECO:0000305|PubMed:7991565}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasmic vesicle {ECO:0000269|PubMed:10818110}. Cell projection, ruffle {ECO:0000250|UniProtKB:P18066}. Membrane {ECO:0000269|PubMed:23815289}. Cytoplasm, cytosol {ECO:0000269|PubMed:23382462}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9CQD1}. Endosome membrane {ECO:0000269|PubMed:22431521, ECO:0000269|PubMed:23382462}. Note=Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable). {ECO:0000269|PubMed:17081065, ECO:0000305}.
P20340	reviewed	RAB6A_HUMAN	Ras-related protein Rab-6A (Rab-6)	RAB6A RAB6	Homo sapiens (Human)	208	FUNCTION: Regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}.		antigen processing and presentation [GO:0019882]; early endosome to Golgi transport [GO:0034498]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; localization [GO:0051179]; minus-end-directed organelle transport along microtubule [GO:0072385]; neuron projection development [GO:0031175]; peptidyl-cysteine methylation [GO:0018125]; protein localization to Golgi apparatus [GO:0034067]; protein localization to Golgi membrane [GO:1903292]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	acrosomal membrane [GO:0002080]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endosome to plasma membrane transport vesicle [GO:0070381]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904]	acrosomal membrane [GO:0002080]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endosome to plasma membrane transport vesicle [GO:0070381]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904]; antigen processing and presentation [GO:0019882]; early endosome to Golgi transport [GO:0034498]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; localization [GO:0051179]; minus-end-directed organelle transport along microtubule [GO:0072385]; neuron projection development [GO:0031175]; peptidyl-cysteine methylation [GO:0018125]; protein localization to Golgi apparatus [GO:0034067]; protein localization to Golgi membrane [GO:1903292]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:25962623}; Lipid-anchor {ECO:0000269|PubMed:25962623}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P35279}; Peripheral membrane protein {ECO:0000305}. Note=BICD2 facilitates its targeting to Golgi apparatus membrane. {ECO:0000269|PubMed:25962623}.; SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:11071909}; Lipid-anchor {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane {ECO:0000269|PubMed:11071909}; Lipid-anchor {ECO:0000305}.
P20366	reviewed	TKN1_HUMAN	Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]	TAC1 NKA NKNA TAC2	Homo sapiens (Human)	129	FUNCTION: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.		cell-cell signaling [GO:0007267]; cellular response to nerve growth factor stimulus [GO:1990090]; chemical synaptic transmission [GO:0007268]; detection of abiotic stimulus [GO:0009582]; inflammatory response [GO:0006954]; insemination [GO:0007320]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to pain [GO:0048265]; sensory perception of pain [GO:0019233]; tachykinin receptor signaling pathway [GO:0007217]	axon [GO:0030424]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; synapse [GO:0045202]	substance P receptor binding [GO:0031835]	axon [GO:0030424]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; synapse [GO:0045202]; substance P receptor binding [GO:0031835]; cell-cell signaling [GO:0007267]; cellular response to nerve growth factor stimulus [GO:1990090]; chemical synaptic transmission [GO:0007268]; detection of abiotic stimulus [GO:0009582]; inflammatory response [GO:0006954]; insemination [GO:0007320]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to pain [GO:0048265]; sensory perception of pain [GO:0019233]; tachykinin receptor signaling pathway [GO:0007217]	SUBCELLULAR LOCATION: Secreted.
P20393	reviewed	NR1D1_HUMAN	Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1)	NR1D1 EAR1 HREV THRAL	Homo sapiens (Human)	614	FUNCTION: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity). {ECO:0000250|UniProtKB:Q3UV55, ECO:0000269|PubMed:12021280, ECO:0000269|PubMed:15761026, ECO:0000269|PubMed:16968709, ECO:0000269|PubMed:18006707, ECO:0000269|PubMed:19710360, ECO:0000269|PubMed:1971514, ECO:0000269|PubMed:21479263, ECO:0000269|PubMed:22184247, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:2539258}.		cell differentiation [GO:0030154]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; circadian regulation of gene expression [GO:0032922]; circadian temperature homeostasis [GO:0060086]; glycogen biosynthetic process [GO:0005978]; hormone-mediated signaling pathway [GO:0009755]; intracellular glucose homeostasis [GO:0001678]; negative regulation of astrocyte activation [GO:0061889]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of bile acid biosynthetic process [GO:0070859]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasomal protein catabolic process [GO:0010498]; protein destabilization [GO:0031648]; regulation of circadian rhythm [GO:0042752]; regulation of circadian sleep/wake cycle [GO:0042749]; regulation of fat cell differentiation [GO:0045598]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of lipid metabolic process [GO:0019216]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to leptin [GO:0044321]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; heme binding [GO:0020037]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; heme binding [GO:0020037]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; circadian regulation of gene expression [GO:0032922]; circadian temperature homeostasis [GO:0060086]; glycogen biosynthetic process [GO:0005978]; hormone-mediated signaling pathway [GO:0009755]; intracellular glucose homeostasis [GO:0001678]; negative regulation of astrocyte activation [GO:0061889]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of bile acid biosynthetic process [GO:0070859]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasomal protein catabolic process [GO:0010498]; protein destabilization [GO:0031648]; regulation of circadian rhythm [GO:0042752]; regulation of circadian sleep/wake cycle [GO:0042749]; regulation of fat cell differentiation [GO:0045598]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of lipid metabolic process [GO:0019216]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to leptin [GO:0044321]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3UV55}. Cytoplasm {ECO:0000250|UniProtKB:Q3UV55}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q3UV55}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q3UV55}. Note=Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. Localizes predominantly to the nucleus at ZT8 whereas it is cytoplasmic at ZT20. Phosphorylation by CSNK1E enhances its cytoplasmic localization. {ECO:0000250|UniProtKB:Q3UV55}.
P20396	reviewed	TRH_HUMAN	Pro-thyrotropin-releasing hormone (Pro-TRH) (Prothyroliberin) [Cleaved into: Thyrotropin-releasing hormone (TRH) (Protirelin) (TSH-releasing factor) (Thyroliberin) (Thyrotropin-releasing factor) (TRF)]	TRH	Homo sapiens (Human)	242	FUNCTION: As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes. {ECO:0000269|PubMed:19825978}.		adult walking behavior [GO:0007628]; cell-cell signaling [GO:0007267]; eating behavior [GO:0042755]; histamine metabolic process [GO:0001692]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of glutamate secretion [GO:0014050]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of insulin secretion [GO:0032024]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; secretory granule [GO:0030141]	thyrotropin-releasing hormone activity [GO:0008437]	extracellular region [GO:0005576]; secretory granule [GO:0030141]; thyrotropin-releasing hormone activity [GO:0008437]; adult walking behavior [GO:0007628]; cell-cell signaling [GO:0007267]; eating behavior [GO:0042755]; histamine metabolic process [GO:0001692]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of glutamate secretion [GO:0014050]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of insulin secretion [GO:0032024]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P20472	reviewed	PRVA_HUMAN	Parvalbumin alpha	PVALB	Homo sapiens (Human)	110	FUNCTION: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.		excitatory chemical synaptic transmission [GO:0098976]; gene expression [GO:0010467]; inhibitory chemical synaptic transmission [GO:0098977]	axon [GO:0030424]; cytoplasm [GO:0005737]; synapse [GO:0045202]	calcium ion binding [GO:0005509]	axon [GO:0030424]; cytoplasm [GO:0005737]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; excitatory chemical synaptic transmission [GO:0098976]; gene expression [GO:0010467]; inhibitory chemical synaptic transmission [GO:0098977]	
P20585	reviewed	MSH3_HUMAN	DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1)	MSH3 DUC1 DUG	Homo sapiens (Human)	1137	FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.		DNA repair [GO:0006281]; maintenance of DNA repeat elements [GO:0043570]; mismatch repair [GO:0006298]; mitotic recombination [GO:0006312]; negative regulation of DNA recombination [GO:0045910]; positive regulation of helicase activity [GO:0051096]; somatic recombination of immunoglobulin gene segments [GO:0016447]	membrane [GO:0016020]; MutSbeta complex [GO:0032302]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; mismatched DNA binding [GO:0030983]	membrane [GO:0016020]; MutSbeta complex [GO:0032302]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; mismatched DNA binding [GO:0030983]; DNA repair [GO:0006281]; maintenance of DNA repeat elements [GO:0043570]; mismatch repair [GO:0006298]; mitotic recombination [GO:0006312]; negative regulation of DNA recombination [GO:0045910]; positive regulation of helicase activity [GO:0051096]; somatic recombination of immunoglobulin gene segments [GO:0016447]	
P20591	reviewed	MX1_HUMAN	Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding protein Mx1, N-terminally processed]	MX1	Homo sapiens (Human)	662	FUNCTION: Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs. {ECO:0000269|PubMed:11880649, ECO:0000269|PubMed:14687945, ECO:0000269|PubMed:14752052, ECO:0000269|PubMed:15047845, ECO:0000269|PubMed:15355513, ECO:0000269|PubMed:15757897, ECO:0000269|PubMed:16202617, ECO:0000269|PubMed:16413306, ECO:0000269|PubMed:17374778, ECO:0000269|PubMed:18668195, ECO:0000269|PubMed:19109387, ECO:0000269|PubMed:21900240, ECO:0000269|PubMed:21992152}.		antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; defense response [GO:0006952]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of viral genome replication [GO:0045071]; response to type I interferon [GO:0034340]; response to virus [GO:0009615]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; defense response [GO:0006952]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of viral genome replication [GO:0045071]; response to type I interferon [GO:0034340]; response to virus [GO:0009615]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11880649, ECO:0000269|PubMed:21859714, ECO:0000269|PubMed:21992152, ECO:0000269|PubMed:9060610}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15355513, ECO:0000269|PubMed:16413306, ECO:0000269|PubMed:21992152}; Peripheral membrane protein {ECO:0000269|PubMed:16413306}; Cytoplasmic side. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15047845}. Note=Binds preferentially to negatively charged phospholipids (PubMed:21900240). Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845). {ECO:0000269|PubMed:15047845, ECO:0000269|PubMed:21900240}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:20603636}. Nucleus {ECO:0000269|PubMed:20603636}. Note=Translocates into the nuclei of HSV-1 infected cells (PubMed:20603636). {ECO:0000269|PubMed:20603636}.
P20592	reviewed	MX2_HUMAN	Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (Myxovirus resistance protein 2) (p78-related protein)	MX2	Homo sapiens (Human)	715	FUNCTION: Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. {ECO:0000269|PubMed:15184662, ECO:0000269|PubMed:24048477, ECO:0000269|PubMed:24055605, ECO:0000269|PubMed:24121441}.		defense response [GO:0006952]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; mRNA transport [GO:0051028]; protein transport [GO:0015031]; regulation of cell cycle [GO:0051726]; regulation of nucleocytoplasmic transport [GO:0046822]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear pore [GO:0005643]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; defense response [GO:0006952]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; mRNA transport [GO:0051028]; protein transport [GO:0015031]; regulation of cell cycle [GO:0051726]; regulation of nucleocytoplasmic transport [GO:0046822]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15184662}. Nucleus {ECO:0000269|PubMed:15184662}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15184662}. Note=Localization to nuclear pores requires GTP-binding.
P20594	reviewed	ANPRB_HUMAN	Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B)	NPR2 ANPRB	Homo sapiens (Human)	1047	FUNCTION: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. {ECO:0000269|PubMed:15146390, ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:24001744, ECO:0000269|PubMed:24471569, ECO:0000269|PubMed:26980729}.	MISCELLANEOUS: [Isoform Short]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	activation of meiosis involved in egg activation [GO:0060466]; axonogenesis involved in innervation [GO:0060385]; blood vessel remodeling [GO:0001974]; c-di-GMP signaling [GO:0061939]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to peptide [GO:1901653]; cGMP biosynthetic process [GO:0006182]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; chromosome organization [GO:0051276]; collateral sprouting [GO:0048668]; cumulus cell differentiation [GO:0001549]; digestive tract morphogenesis [GO:0048546]; endochondral ossification [GO:0001958]; epidermal growth factor receptor signaling pathway [GO:0007173]; execution phase of apoptosis [GO:0097194]; female genitalia development [GO:0030540]; gastric emptying [GO:0035483]; genitalia morphogenesis [GO:0035112]; growth plate cartilage development [GO:0003417]; limb morphogenesis [GO:0035108]; lymph vessel development [GO:0001945]; MAPK cascade [GO:0000165]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; multicellular organism growth [GO:0035264]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of oocyte maturation [GO:1900194]; neuron apoptotic process [GO:0051402]; neuronal action potential [GO:0019228]; post-anal tail morphogenesis [GO:0036342]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; response to fibroblast growth factor [GO:0071774]; response to luteinizing hormone [GO:0034699]; response to salt [GO:1902074]; sensory perception of sound [GO:0007605]; smooth muscle tissue development [GO:0048745]; spermatogenesis [GO:0007283]; startle response [GO:0001964]; vacuole organization [GO:0007033]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]; vestibulocochlear nerve maturation [GO:0021647]; white fat cell differentiation [GO:0050872]	cilium [GO:0005929]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; identical protein binding [GO:0042802]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; protein kinase activity [GO:0004672]	cilium [GO:0005929]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; identical protein binding [GO:0042802]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; protein kinase activity [GO:0004672]; activation of meiosis involved in egg activation [GO:0060466]; axonogenesis involved in innervation [GO:0060385]; blood vessel remodeling [GO:0001974]; c-di-GMP signaling [GO:0061939]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to peptide [GO:1901653]; cGMP biosynthetic process [GO:0006182]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; chromosome organization [GO:0051276]; collateral sprouting [GO:0048668]; cumulus cell differentiation [GO:0001549]; digestive tract morphogenesis [GO:0048546]; endochondral ossification [GO:0001958]; epidermal growth factor receptor signaling pathway [GO:0007173]; execution phase of apoptosis [GO:0097194]; female genitalia development [GO:0030540]; gastric emptying [GO:0035483]; genitalia morphogenesis [GO:0035112]; growth plate cartilage development [GO:0003417]; limb morphogenesis [GO:0035108]; lymph vessel development [GO:0001945]; MAPK cascade [GO:0000165]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; multicellular organism growth [GO:0035264]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of oocyte maturation [GO:1900194]; neuron apoptotic process [GO:0051402]; neuronal action potential [GO:0019228]; post-anal tail morphogenesis [GO:0036342]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; response to fibroblast growth factor [GO:0071774]; response to luteinizing hormone [GO:0034699]; response to salt [GO:1902074]; sensory perception of sound [GO:0007605]; smooth muscle tissue development [GO:0048745]; spermatogenesis [GO:0007283]; startle response [GO:0001964]; vacuole organization [GO:0007033]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]; vestibulocochlear nerve maturation [GO:0021647]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24001744, ECO:0000269|PubMed:26980729}; Single-pass type I membrane protein {ECO:0000305|PubMed:26980729}.
P20618	reviewed	PSB1_HUMAN	Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain)	PSMB1 PSC5	Homo sapiens (Human)	241	FUNCTION: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; secretory granule lumen [GO:0034774]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; secretory granule lumen [GO:0034774]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
P20645	reviewed	MPRD_HUMAN	Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)	M6PR MPR46 MPRD	Homo sapiens (Human)	277	FUNCTION: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.	MISCELLANEOUS: This receptor has optimal binding in the presence of divalent cations.	endosome to lysosome transport [GO:0008333]; lysosomal transport [GO:0007041]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; secretion of lysosomal enzymes [GO:0033299]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endosome [GO:0005768]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]	protein domain specific binding [GO:0019904]; retromer complex binding [GO:1905394]; transmembrane signaling receptor activity [GO:0004888]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endosome [GO:0005768]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; protein domain specific binding [GO:0019904]; retromer complex binding [GO:1905394]; transmembrane signaling receptor activity [GO:0004888]; endosome to lysosome transport [GO:0008333]; lysosomal transport [GO:0007041]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; secretion of lysosomal enzymes [GO:0033299]	SUBCELLULAR LOCATION: Lysosome membrane; Single-pass type I membrane protein.
P20648	reviewed	ATP4A_HUMAN	Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)	ATP4A	Homo sapiens (Human)	1035	FUNCTION: The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity). {ECO:0000250|UniProtKB:P09626, ECO:0000250|UniProtKB:P19156, ECO:0000250|UniProtKB:Q64436}.		intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; monoatomic ion transmembrane transport [GO:0034220]; pH reduction [GO:0045851]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; proton transmembrane transport [GO:1902600]; regulation of proton transport [GO:0010155]; response to xenobiotic stimulus [GO:0009410]; sodium ion export across plasma membrane [GO:0036376]	apical plasma membrane [GO:0016324]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; potassium:proton exchanging ATPase complex [GO:0005889]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; magnesium ion binding [GO:0000287]; P-type potassium:proton transporter activity [GO:0008900]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; potassium ion binding [GO:0030955]	apical plasma membrane [GO:0016324]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; potassium:proton exchanging ATPase complex [GO:0005889]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; magnesium ion binding [GO:0000287]; P-type potassium:proton transporter activity [GO:0008900]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; potassium ion binding [GO:0030955]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; monoatomic ion transmembrane transport [GO:0034220]; pH reduction [GO:0045851]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; proton transmembrane transport [GO:1902600]; regulation of proton transport [GO:0010155]; response to xenobiotic stimulus [GO:0009410]; sodium ion export across plasma membrane [GO:0036376]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:24188822}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the apical canalicular membrane of parietal cells (PubMed:24188822). Localized in the apical canalicular membrane of parietal cells (PubMed:24188822). {ECO:0000269|PubMed:24188822}.
P20671	reviewed	H2A1D_HUMAN	Histone H2A type 1-D (Histone H2A.3) (Histone H2A/g)	H2AC7 H2AFG HIST1H2AD	Homo sapiens (Human)	130	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.			extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P20674	reviewed	COX5A_HUMAN	Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)	COX5A	Homo sapiens (Human)	150	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00427}.		cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]	cytochrome-c oxidase activity [GO:0004129]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; cytochrome-c oxidase activity [GO:0004129]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Peripheral membrane protein {ECO:0000269|PubMed:30030519}; Matrix side {ECO:0000269|PubMed:30030519}.
P20700	reviewed	LMNB1_HUMAN	Lamin-B1	LMNB1 LMN2 LMNB	Homo sapiens (Human)	586	FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}.	MISCELLANEOUS: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.	heterochromatin formation [GO:0031507]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; protein localization to nuclear envelope [GO:0090435]	lamin filament [GO:0005638]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	phospholipase binding [GO:0043274]; sequence-specific double-stranded DNA binding [GO:1990837]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]	lamin filament [GO:0005638]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phospholipase binding [GO:0043274]; sequence-specific double-stranded DNA binding [GO:1990837]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; heterochromatin formation [GO:0031507]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; protein localization to nuclear envelope [GO:0090435]	SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}.
P20701	reviewed	ITAL_HUMAN	Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)	ITGAL CD11A	Homo sapiens (Human)	1170	FUNCTION: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000250|UniProtKB:P24063, ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:15528364, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:29100055}.		cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; memory T cell extravasation [GO:0035683]; phagocytosis [GO:0006909]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; integrin alphaL-beta2 complex [GO:0034687]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	cell adhesion molecule binding [GO:0050839]; ICAM-3 receptor activity [GO:0030369]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; integrin alphaL-beta2 complex [GO:0034687]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; cell adhesion molecule binding [GO:0050839]; ICAM-3 receptor activity [GO:0030369]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; memory T cell extravasation [GO:0035683]; phagocytosis [GO:0006909]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16301335}; Single-pass type I membrane protein {ECO:0000255}.
P20702	reviewed	ITAX_HUMAN	Integrin alpha-X (CD11 antigen-like family member C) (Leu M5) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c)	ITGAX CD11C	Homo sapiens (Human)	1163	FUNCTION: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.		animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; defense response to virus [GO:0051607]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial tube morphogenesis [GO:1905956]; positive regulation of gene expression [GO:0010628]; positive regulation of myelination [GO:0031643]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; ficolin-1-rich granule membrane [GO:0101003]; integrin alphaX-beta2 complex [GO:0034689]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]	integrin binding [GO:0005178]; metal ion binding [GO:0046872]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; ficolin-1-rich granule membrane [GO:0101003]; integrin alphaX-beta2 complex [GO:0034689]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor activity [GO:0038023]; animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; defense response to virus [GO:0051607]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial tube morphogenesis [GO:1905956]; positive regulation of gene expression [GO:0010628]; positive regulation of myelination [GO:0031643]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P20711	reviewed	DDC_HUMAN	Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC)	DDC AADC	Homo sapiens (Human)	480	FUNCTION: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin. {ECO:0000250|UniProtKB:P80041}.		amino acid metabolic process [GO:0006520]; catecholamine metabolic process [GO:0006584]; dopamine biosynthetic process [GO:0042416]; response to toxic substance [GO:0009636]; serotonin biosynthetic process [GO:0042427]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	5-hydroxy-L-tryptophan decarboxylase activity [GO:0036467]; aromatic-L-amino-acid decarboxylase activity [GO:0004058]; enzyme binding [GO:0019899]; L-dopa decarboxylase activity [GO:0036468]; pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 5-hydroxy-L-tryptophan decarboxylase activity [GO:0036467]; aromatic-L-amino-acid decarboxylase activity [GO:0004058]; enzyme binding [GO:0019899]; L-dopa decarboxylase activity [GO:0036468]; pyridoxal phosphate binding [GO:0030170]; amino acid metabolic process [GO:0006520]; catecholamine metabolic process [GO:0006584]; dopamine biosynthetic process [GO:0042416]; response to toxic substance [GO:0009636]; serotonin biosynthetic process [GO:0042427]	
P20718	reviewed	GRAH_HUMAN	Granzyme H (EC 3.4.21.-) (CCP-X) (Cathepsin G-like 2) (CTSGL2) (Cytotoxic T-lymphocyte proteinase) (Cytotoxic serine protease C) (CSP-C)	GZMH CGL2 CTSGL2	Homo sapiens (Human)	246	FUNCTION: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. {ECO:0000269|PubMed:22156497, ECO:0000269|PubMed:23269243}.		apoptotic process [GO:0006915]; killing of cells of another organism [GO:0031640]; proteolysis [GO:0006508]	cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	serine-type endopeptidase activity [GO:0004252]	cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; serine-type endopeptidase activity [GO:0004252]; apoptotic process [GO:0006915]; killing of cells of another organism [GO:0031640]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytolytic granule {ECO:0000269|PubMed:23269243}.
P20719	reviewed	HXA5_HUMAN	Homeobox protein Hox-A5 (Homeobox protein Hox-1C)	HOXA5 HOX1C	Homo sapiens (Human)	270	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.		anterior/posterior pattern specification [GO:0009952]; bronchiole development [GO:0060435]; cell migration [GO:0016477]; cell-cell signaling involved in mammary gland development [GO:0060764]; embryonic skeletal system morphogenesis [GO:0048704]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; intestinal epithelial cell maturation [GO:0060574]; lung alveolus development [GO:0048286]; lung goblet cell differentiation [GO:0060480]; lung-associated mesenchyme development [GO:0060484]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell differentiation [GO:0060644]; mesenchymal-epithelial cell signaling [GO:0060638]; multicellular organism growth [GO:0035264]; negative regulation of angiogenesis [GO:0016525]; negative regulation of erythrocyte differentiation [GO:0045647]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory system process [GO:0003016]; thyroid gland development [GO:0030878]; trachea cartilage morphogenesis [GO:0060535]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; bronchiole development [GO:0060435]; cell migration [GO:0016477]; cell-cell signaling involved in mammary gland development [GO:0060764]; embryonic skeletal system morphogenesis [GO:0048704]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; intestinal epithelial cell maturation [GO:0060574]; lung alveolus development [GO:0048286]; lung goblet cell differentiation [GO:0060480]; lung-associated mesenchyme development [GO:0060484]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell differentiation [GO:0060644]; mesenchymal-epithelial cell signaling [GO:0060638]; multicellular organism growth [GO:0035264]; negative regulation of angiogenesis [GO:0016525]; negative regulation of erythrocyte differentiation [GO:0045647]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory system process [GO:0003016]; thyroid gland development [GO:0030878]; trachea cartilage morphogenesis [GO:0060535]	SUBCELLULAR LOCATION: Nucleus.
P20742	reviewed	PZP_HUMAN	Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6)	PZP CPAMD6	Homo sapiens (Human)	1482	FUNCTION: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.		female pregnancy [GO:0007565]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	endopeptidase inhibitor activity [GO:0004866]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; endopeptidase inhibitor activity [GO:0004866]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; female pregnancy [GO:0007565]	SUBCELLULAR LOCATION: Secreted.
P20749	reviewed	BCL3_HUMAN	B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3)	BCL3 BCL4 D19S37	Homo sapiens (Human)	454	FUNCTION: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250, ECO:0000269|PubMed:8453667}.		antimicrobial humoral response [GO:0019730]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of type II interferon production [GO:0032729]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of DNA binding [GO:0051101]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to UV-C [GO:0010225]; response to virus [GO:0009615]; spleen development [GO:0048536]; T cell apoptotic process [GO:0070231]; T-helper 1 type immune response [GO:0042088]; T-helper 2 cell differentiation [GO:0045064]	Bcl3-Bcl10 complex [GO:0032996]; Bcl3/NF-kappaB2 complex [GO:0033257]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	Bcl3-Bcl10 complex [GO:0032996]; Bcl3/NF-kappaB2 complex [GO:0033257]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; antimicrobial humoral response [GO:0019730]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of type II interferon production [GO:0032729]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of DNA binding [GO:0051101]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to UV-C [GO:0010225]; response to virus [GO:0009615]; spleen development [GO:0048536]; T cell apoptotic process [GO:0070231]; T-helper 1 type immune response [GO:0042088]; T-helper 2 cell differentiation [GO:0045064]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. {ECO:0000250}.
P20774	reviewed	MIME_HUMAN	Mimecan (Osteoglycin) (Osteoinductive factor) (OIF)	OGN OIF SLRR3A	Homo sapiens (Human)	298	FUNCTION: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2. {ECO:0000250|UniProtKB:P19879}.		articular cartilage development [GO:0061975]; bone development [GO:0060348]; negative regulation of smooth muscle cell proliferation [GO:0048662]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]	growth factor activity [GO:0008083]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; growth factor activity [GO:0008083]; articular cartilage development [GO:0061975]; bone development [GO:0060348]; negative regulation of smooth muscle cell proliferation [GO:0048662]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q8MJF1}.
P20783	reviewed	NTF3_HUMAN	Neurotrophin-3 (NT-3) (HDNF) (Nerve growth factor 2) (NGF-2) (Neurotrophic factor)	NTF3	Homo sapiens (Human)	257	FUNCTION: Seems to promote the survival of visceral and proprioceptive sensory neurons.		activation of GTPase activity [GO:0090630]; activation of protein kinase B activity [GO:0032148]; cell-cell signaling [GO:0007267]; induction of positive chemotaxis [GO:0050930]; memory [GO:0007613]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; peripheral nervous system development [GO:0007422]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of receptor internalization [GO:0002092]; regulation of apoptotic process [GO:0042981]; regulation of neuron differentiation [GO:0045664]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; synaptic vesicle [GO:0008021]	chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; nerve growth factor receptor binding [GO:0005163]; signaling receptor binding [GO:0005102]	axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; synaptic vesicle [GO:0008021]; chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; nerve growth factor receptor binding [GO:0005163]; signaling receptor binding [GO:0005102]; activation of GTPase activity [GO:0090630]; activation of protein kinase B activity [GO:0032148]; cell-cell signaling [GO:0007267]; induction of positive chemotaxis [GO:0050930]; memory [GO:0007613]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; peripheral nervous system development [GO:0007422]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of receptor internalization [GO:0002092]; regulation of apoptotic process [GO:0042981]; regulation of neuron differentiation [GO:0045664]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Secreted.
P20794	reviewed	MAK_HUMAN	Serine/threonine-protein kinase MAK (EC 2.7.11.1) (Male germ cell-associated kinase)	MAK	Homo sapiens (Human)	623	FUNCTION: Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. {ECO:0000250, ECO:0000269|PubMed:12084720, ECO:0000269|PubMed:16951154, ECO:0000269|PubMed:21986944}.		cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; intraciliary transport [GO:0042073]; negative regulation of non-motile cilium assembly [GO:1902856]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283]	axoneme [GO:0005930]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; motile cilium [GO:0031514]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transcription coactivator activity [GO:0003713]	axoneme [GO:0005930]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; motile cilium [GO:0031514]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transcription coactivator activity [GO:0003713]; cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; intraciliary transport [GO:0042073]; negative regulation of non-motile cilium assembly [GO:1902856]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Photoreceptor inner segment. Note=Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase. {ECO:0000250}.
P20800	reviewed	EDN2_HUMAN	Endothelin-2 (ET-2) (Preproendothelin-2) (PPET2)	EDN2	Homo sapiens (Human)	178	FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides.		angiogenesis [GO:0001525]; artery smooth muscle contraction [GO:0014824]; axon extension [GO:0048675]; calcium-mediated signaling [GO:0019722]; cell surface receptor signaling pathway [GO:0007166]; cell tip growth [GO:0009932]; cytokine-mediated signaling pathway [GO:0019221]; endothelial cell migration [GO:0043542]; energy homeostasis [GO:0097009]; hormonal regulation of the force of heart contraction [GO:0003058]; inositol phosphate-mediated signaling [GO:0048016]; intracellular calcium ion homeostasis [GO:0006874]; lung alveolus development [GO:0048286]; macrophage activation [GO:0042116]; macrophage chemotaxis [GO:0048246]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of heart rate [GO:0010460]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of prostaglandin-endoperoxide synthase activity [GO:0060585]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of the force of heart contraction by chemical signal [GO:0003099]; prostaglandin biosynthetic process [GO:0001516]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; temperature homeostasis [GO:0001659]; vasoconstriction [GO:0042310]; vein smooth muscle contraction [GO:0014826]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	endothelin B receptor binding [GO:0031708]; hormone activity [GO:0005179]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; endothelin B receptor binding [GO:0031708]; hormone activity [GO:0005179]; angiogenesis [GO:0001525]; artery smooth muscle contraction [GO:0014824]; axon extension [GO:0048675]; calcium-mediated signaling [GO:0019722]; cell surface receptor signaling pathway [GO:0007166]; cell tip growth [GO:0009932]; cytokine-mediated signaling pathway [GO:0019221]; endothelial cell migration [GO:0043542]; energy homeostasis [GO:0097009]; hormonal regulation of the force of heart contraction [GO:0003058]; inositol phosphate-mediated signaling [GO:0048016]; intracellular calcium ion homeostasis [GO:0006874]; lung alveolus development [GO:0048286]; macrophage activation [GO:0042116]; macrophage chemotaxis [GO:0048246]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of heart rate [GO:0010460]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of prostaglandin-endoperoxide synthase activity [GO:0060585]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of the force of heart contraction by chemical signal [GO:0003099]; prostaglandin biosynthetic process [GO:0001516]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; temperature homeostasis [GO:0001659]; vasoconstriction [GO:0042310]; vein smooth muscle contraction [GO:0014826]	SUBCELLULAR LOCATION: Secreted.
P20807	reviewed	CAN3_HUMAN	Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1)	CAPN3 CANP3 CANPL3 NCL1	Homo sapiens (Human)	821	FUNCTION: Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). {ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:27657329}.		apoptotic process [GO:0006915]; calcium-dependent self proteolysis [GO:1990092]; cellular response to calcium ion [GO:0071277]; cellular response to salt stress [GO:0071472]; G1 to G0 transition involved in cell differentiation [GO:0070315]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein sumoylation [GO:0033234]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014718]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to membrane [GO:0072657]; protein-containing complex assembly [GO:0065003]; proteolysis [GO:0006508]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of catalytic activity [GO:0050790]; regulation of myoblast differentiation [GO:0045661]; response to calcium ion [GO:0051592]; response to muscle activity [GO:0014850]; sarcomere organization [GO:0045214]; self proteolysis [GO:0097264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; myofibril [GO:0030016]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; T-tubule [GO:0030315]; Z disc [GO:0030018]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; catalytic activity [GO:0003824]; cysteine-type peptidase activity [GO:0008234]; identical protein binding [GO:0042802]; ligase regulator activity [GO:0055103]; molecular adaptor activity [GO:0060090]; peptidase activity [GO:0008233]; sodium ion binding [GO:0031402]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; myofibril [GO:0030016]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; T-tubule [GO:0030315]; Z disc [GO:0030018]; calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; catalytic activity [GO:0003824]; cysteine-type peptidase activity [GO:0008234]; identical protein binding [GO:0042802]; ligase regulator activity [GO:0055103]; molecular adaptor activity [GO:0060090]; peptidase activity [GO:0008233]; sodium ion binding [GO:0031402]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]; apoptotic process [GO:0006915]; calcium-dependent self proteolysis [GO:1990092]; cellular response to calcium ion [GO:0071277]; cellular response to salt stress [GO:0071472]; G1 to G0 transition involved in cell differentiation [GO:0070315]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein sumoylation [GO:0033234]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014718]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to membrane [GO:0072657]; protein-containing complex assembly [GO:0065003]; proteolysis [GO:0006508]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of catalytic activity [GO:0050790]; regulation of myoblast differentiation [GO:0045661]; response to calcium ion [GO:0051592]; response to muscle activity [GO:0014850]; sarcomere organization [GO:0045214]; self proteolysis [GO:0097264]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus {ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:27657329}.
P20809	reviewed	IL11_HUMAN	Interleukin-11 (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin)	IL11	Homo sapiens (Human)	199	FUNCTION: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168). {ECO:0000250|UniProtKB:P47873, ECO:0000269|PubMed:12919066, ECO:0000269|PubMed:2145578, ECO:0000269|PubMed:30279168}.		B cell differentiation [GO:0030183]; cell population proliferation [GO:0008283]; fat cell differentiation [GO:0045444]; interleukin-11-mediated signaling pathway [GO:0038154]; megakaryocyte differentiation [GO:0030219]; negative regulation of hormone secretion [GO:0046888]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-11 receptor binding [GO:0005142]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-11 receptor binding [GO:0005142]; B cell differentiation [GO:0030183]; cell population proliferation [GO:0008283]; fat cell differentiation [GO:0045444]; interleukin-11-mediated signaling pathway [GO:0038154]; megakaryocyte differentiation [GO:0030219]; negative regulation of hormone secretion [GO:0046888]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1828438, ECO:0000269|PubMed:2145578}.
P20810	reviewed	ICAL_HUMAN	Calpastatin (Calpain inhibitor) (Sperm BS-17 component)	CAST	Homo sapiens (Human)	708	FUNCTION: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.		inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; presynaptic active zone organization [GO:1990709]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	cadherin binding [GO:0045296]; calcium-dependent cysteine-type endopeptidase inhibitor activity [GO:0010859]; endopeptidase inhibitor activity [GO:0004866]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; cadherin binding [GO:0045296]; calcium-dependent cysteine-type endopeptidase inhibitor activity [GO:0010859]; endopeptidase inhibitor activity [GO:0004866]; RNA binding [GO:0003723]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; presynaptic active zone organization [GO:1990709]	
P20813	reviewed	CP2B6_HUMAN	Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1)	CYP2B6	Homo sapiens (Human)	491	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:21289075, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed:21289075, PubMed:12865317). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed:11695850, PubMed:22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:21289075, ECO:0000269|PubMed:22909231}.; FUNCTION: Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs. {ECO:0000269|PubMed:21289075}.		cellular ketone metabolic process [GO:0042180]; epoxygenase P450 pathway [GO:0019373]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; arachidonic acid epoxygenase activity [GO:0008392]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; testosterone 16-alpha-hydroxylase activity [GO:0008390]; testosterone 16-beta-hydroxylase activity [GO:0062184]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; arachidonic acid epoxygenase activity [GO:0008392]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; testosterone 16-alpha-hydroxylase activity [GO:0008390]; testosterone 16-beta-hydroxylase activity [GO:0062184]; cellular ketone metabolic process [GO:0042180]; epoxygenase P450 pathway [GO:0019373]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
P20815	reviewed	CP3A5_HUMAN	Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450-PCN3)	CYP3A5	Homo sapiens (Human)	502	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:2732228, PubMed:10681376, PubMed:11093772, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:2732228, PubMed:10681376, PubMed:11093772). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:2732228}.	MISCELLANEOUS: Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664). {ECO:0000305|PubMed:11726664}.	aflatoxin metabolic process [GO:0046222]; alkaloid catabolic process [GO:0009822]; estrogen metabolic process [GO:0008210]; lipid hydroxylation [GO:0002933]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	aromatase activity [GO:0070330]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxygen binding [GO:0019825]; retinoic acid 4-hydroxylase activity [GO:0008401]; testosterone 6-beta-hydroxylase activity [GO:0050649]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; aromatase activity [GO:0070330]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxygen binding [GO:0019825]; retinoic acid 4-hydroxylase activity [GO:0008401]; testosterone 6-beta-hydroxylase activity [GO:0050649]; aflatoxin metabolic process [GO:0046222]; alkaloid catabolic process [GO:0009822]; estrogen metabolic process [GO:0008210]; lipid hydroxylation [GO:0002933]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
P20823	reviewed	HNF1A_HUMAN	Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)	HNF1A TCF1	Homo sapiens (Human)	631	FUNCTION: Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:12453420, PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). {ECO:0000250|UniProtKB:P22361, ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:12453420}.	MISCELLANEOUS: [Isoform 7]: Due to intron retention. {ECO:0000305}.	glucose homeostasis [GO:0042593]; glucose import [GO:0046323]; insulin secretion [GO:0030073]; liver development [GO:0001889]; pancreas development [GO:0031016]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; renal glucose absorption [GO:0035623]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; glucose homeostasis [GO:0042593]; glucose import [GO:0046323]; insulin secretion [GO:0030073]; liver development [GO:0001889]; pancreas development [GO:0031016]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; renal glucose absorption [GO:0035623]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:10966642}.
P20827	reviewed	EFNA1_HUMAN	Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor alpha-induced protein 4) (TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form]	EFNA1 EPLG1 LERK1 TNFAIP4	Homo sapiens (Human)	205	FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269|PubMed:17332925, ECO:0000269|PubMed:18794797}.		angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cell-cell signaling [GO:0007267]; endocardial cushion to mesenchymal transition involved in heart valve formation [GO:0003199]; ephrin receptor signaling pathway [GO:0048013]; mitral valve morphogenesis [GO:0003183]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of proteolysis involved in protein catabolic process [GO:1903051]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; notochord formation [GO:0014028]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; protein stabilization [GO:0050821]; regulation of angiogenesis [GO:0045765]; regulation of axonogenesis [GO:0050770]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; substrate adhesion-dependent cell spreading [GO:0034446]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	ephrin receptor binding [GO:0046875]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; ephrin receptor binding [GO:0046875]; signaling receptor binding [GO:0005102]; angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cell-cell signaling [GO:0007267]; endocardial cushion to mesenchymal transition involved in heart valve formation [GO:0003199]; ephrin receptor signaling pathway [GO:0048013]; mitral valve morphogenesis [GO:0003183]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of proteolysis involved in protein catabolic process [GO:1903051]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; notochord formation [GO:0014028]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; protein stabilization [GO:0050821]; regulation of angiogenesis [GO:0045765]; regulation of axonogenesis [GO:0050770]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18794797}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18794797}.; SUBCELLULAR LOCATION: [Ephrin-A1, secreted form]: Secreted {ECO:0000269|PubMed:18794797}.
P20839	reviewed	IMDH1_HUMAN	Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I)	IMPDH1 IMPD1	Homo sapiens (Human)	514	FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	MISCELLANEOUS: Because IMPDH activity is tightly linked with cell proliferation, it has been recognized as a target for cancer and viral chemotherapy and as a target for immunosuppressive drugs. The activities of the antitumor drug tiazofurin, the antiviral drug ribavirin, and the immunosuppressive drugs mizoribine and mycophenolic acid (MPA) are attributed to the inhibition of IMPDH. In addition, bacterial and parasitic IMPDH's differ significantly from mammalian enzymes, which makes it a suitable target for anti-infective drugs.	GMP biosynthetic process [GO:0006177]; GTP biosynthetic process [GO:0006183]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; IMP dehydrogenase activity [GO:0003938]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; IMP dehydrogenase activity [GO:0003938]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; GMP biosynthetic process [GO:0006177]; GTP biosynthetic process [GO:0006183]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}.
P20848	reviewed	A1ATR_HUMAN	Alpha-1-antitrypsin-related protein (AAT-related protein) (Protease inhibitor 1-like) (Serpin A2)	SERPINA2 ARGS ATR PIL SERPINA2P	Homo sapiens (Human)	421	FUNCTION: Putative serine protease inhibitor.			endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:23826168}.
P20849	reviewed	CO9A1_HUMAN	Collagen alpha-1(IX) chain	COL9A1	Homo sapiens (Human)	921	FUNCTION: Structural component of hyaline cartilage and vitreous of the eye.		animal organ morphogenesis [GO:0009887]; extracellular matrix organization [GO:0030198]	collagen type IX trimer [GO:0005594]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]	collagen type IX trimer [GO:0005594]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; animal organ morphogenesis [GO:0009887]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
P20851	reviewed	C4BPB_HUMAN	C4b-binding protein beta chain	C4BPB	Homo sapiens (Human)	252	FUNCTION: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.		blood coagulation [GO:0007596]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, classical pathway [GO:0045959]; positive regulation of protein catabolic process [GO:0045732]; regulation of opsonization [GO:1903027]; response to symbiotic bacterium [GO:0009609]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; blood coagulation [GO:0007596]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, classical pathway [GO:0045959]; positive regulation of protein catabolic process [GO:0045732]; regulation of opsonization [GO:1903027]; response to symbiotic bacterium [GO:0009609]	SUBCELLULAR LOCATION: Secreted.
P20853	reviewed	CP2A7_HUMAN	Cytochrome P450 2A7 (EC 1.14.14.1) (CYPIIA7) (Cytochrome P450 IIA4)	CYP2A7	Homo sapiens (Human)	494	FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.		coumarin metabolic process [GO:0009804]; epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; coumarin metabolic process [GO:0009804]; epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
P20908	reviewed	CO5A1_HUMAN	Collagen alpha-1(V) chain	COL5A1	Homo sapiens (Human)	1838	FUNCTION: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.		blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; eye morphogenesis [GO:0048592]; heart morphogenesis [GO:0003007]; integrin biosynthetic process [GO:0045112]; negative regulation of endodermal cell differentiation [GO:1903225]; regulation of cellular component organization [GO:0051128]; skin development [GO:0043588]; supramolecular fiber organization [GO:0097435]; tendon development [GO:0035989]; wound healing, spreading of epidermal cells [GO:0035313]	basement membrane [GO:0005604]; collagen type V trimer [GO:0005588]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; proteoglycan binding [GO:0043394]	basement membrane [GO:0005604]; collagen type V trimer [GO:0005588]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; proteoglycan binding [GO:0043394]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; eye morphogenesis [GO:0048592]; heart morphogenesis [GO:0003007]; integrin biosynthetic process [GO:0045112]; negative regulation of endodermal cell differentiation [GO:1903225]; regulation of cellular component organization [GO:0051128]; skin development [GO:0043588]; supramolecular fiber organization [GO:0097435]; tendon development [GO:0035989]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
P20916	reviewed	MAG_HUMAN	Myelin-associated glycoprotein (Siglec-4a)	MAG GMA	Homo sapiens (Human)	626	FUNCTION: Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity). {ECO:0000250|UniProtKB:P07722, ECO:0000250|UniProtKB:P20917}.		axon regeneration [GO:0031103]; cell adhesion [GO:0007155]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cellular response to mechanical stimulus [GO:0071260]; central nervous system myelin formation [GO:0032289]; negative regulation of axon extension [GO:0030517]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of neuron projection development [GO:0010977]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of myelination [GO:0031643]; substantia nigra development [GO:0021762]; transmission of nerve impulse [GO:0019226]	compact myelin [GO:0043218]; membrane raft [GO:0045121]; mesaxon [GO:0097453]; myelin sheath [GO:0043209]; myelin sheath adaxonal region [GO:0035749]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220]	carbohydrate binding [GO:0030246]; ganglioside GT1b binding [GO:1905576]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	compact myelin [GO:0043218]; membrane raft [GO:0045121]; mesaxon [GO:0097453]; myelin sheath [GO:0043209]; myelin sheath adaxonal region [GO:0035749]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220]; carbohydrate binding [GO:0030246]; ganglioside GT1b binding [GO:1905576]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]; axon regeneration [GO:0031103]; cell adhesion [GO:0007155]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cellular response to mechanical stimulus [GO:0071260]; central nervous system myelin formation [GO:0032289]; negative regulation of axon extension [GO:0030517]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of neuron projection development [GO:0010977]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of myelination [GO:0031643]; substantia nigra development [GO:0021762]; transmission of nerve impulse [GO:0019226]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26179919}; Single-pass type I membrane protein {ECO:0000269|PubMed:26179919}. Membrane raft {ECO:0000250|UniProtKB:P07722}.
P20929	reviewed	NEBU_HUMAN	Nebulin	NEB	Homo sapiens (Human)	6669	FUNCTION: This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin.		cardiac muscle thin filament assembly [GO:0071691]; muscle organ development [GO:0007517]; regulation of actin filament length [GO:0030832]; somatic muscle development [GO:0007525]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; structural constituent of muscle [GO:0008307]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; structural constituent of muscle [GO:0008307]; cardiac muscle thin filament assembly [GO:0071691]; muscle organ development [GO:0007517]; regulation of actin filament length [GO:0030832]; somatic muscle development [GO:0007525]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton.
P20930	reviewed	FILA_HUMAN	Filaggrin	FLG	Homo sapiens (Human)	4061	FUNCTION: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.		establishment of skin barrier [GO:0061436]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]	collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; structural constituent of skin epidermis [GO:0030280]; transition metal ion binding [GO:0046914]	collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; structural constituent of skin epidermis [GO:0030280]; transition metal ion binding [GO:0046914]; establishment of skin barrier [GO:0061436]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]	SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000269|PubMed:16710414}. Note=In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719). {ECO:0000269|PubMed:1429717, ECO:0000269|PubMed:21531719}.
P20933	reviewed	ASPG_HUMAN	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain]	AGA	Homo sapiens (Human)	346	FUNCTION: Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. {ECO:0000269|PubMed:1703489, ECO:0000269|PubMed:1904874, ECO:0000269|PubMed:2401370}.		protein deglycosylation [GO:0006517]; proteolysis [GO:0006508]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]	asparaginase activity [GO:0004067]; beta-aspartyl-peptidase activity [GO:0008798]; N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity [GO:0003948]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; asparaginase activity [GO:0004067]; beta-aspartyl-peptidase activity [GO:0008798]; N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity [GO:0003948]; protein deglycosylation [GO:0006517]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Lysosome.
P20936	reviewed	RASA1_HUMAN	Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)	RASA1 GAP RASA	Homo sapiens (Human)	1047	FUNCTION: Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1. {ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:8360177}.		blood vessel morphogenesis [GO:0048514]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of RNA metabolic process [GO:0051252]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; phosphotyrosine residue binding [GO:0001784]; potassium channel inhibitor activity [GO:0019870]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; phosphotyrosine residue binding [GO:0001784]; potassium channel inhibitor activity [GO:0019870]; signaling receptor binding [GO:0005102]; blood vessel morphogenesis [GO:0048514]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of RNA metabolic process [GO:0051252]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8360177}.
P20941	reviewed	PHOS_HUMAN	Phosducin (PHD) (33 kDa phototransducing protein) (Protein MEKA)	PDC	Homo sapiens (Human)	246	FUNCTION: May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX. {ECO:0000269|PubMed:10866677}.		G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; visual perception [GO:0007601]	cytosol [GO:0005829]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	phospholipase inhibitor activity [GO:0004859]	cytosol [GO:0005829]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; phospholipase inhibitor activity [GO:0004859]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10866677}. Nucleus {ECO:0000269|PubMed:10866677}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P19632}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P19632}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:10866677}.
P20963	reviewed	CD3Z_HUMAN	T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247)	CD247 CD3Z T3Z TCRZ	Homo sapiens (Human)	164	FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity). {ECO:0000250|UniProtKB:P24161, ECO:0000269|PubMed:16027224, ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:28465009, ECO:0000269|PubMed:7509083}.		adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; cell surface receptor signaling pathway [GO:0007166]; Fc-gamma receptor signaling pathway [GO:0038094]; gamma-delta T cell activation [GO:0046629]; positive regulation of protein localization to cell surface [GO:2000010]; protein complex oligomerization [GO:0051259]; protein-containing complex assembly [GO:0065003]; T cell receptor signaling pathway [GO:0050852]	alpha-beta T cell receptor complex [GO:0042105]; cytoplasm [GO:0005737]; Fc-gamma receptor III complex [GO:0033001]; gamma-delta T cell receptor complex [GO:0042106]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase binding [GO:1990782]; transmembrane signaling receptor activity [GO:0004888]	alpha-beta T cell receptor complex [GO:0042105]; cytoplasm [GO:0005737]; Fc-gamma receptor III complex [GO:0033001]; gamma-delta T cell receptor complex [GO:0042106]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase binding [GO:1990782]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; cell surface receptor signaling pathway [GO:0007166]; Fc-gamma receptor signaling pathway [GO:0038094]; gamma-delta T cell activation [GO:0046629]; positive regulation of protein localization to cell surface [GO:2000010]; protein complex oligomerization [GO:0051259]; protein-containing complex assembly [GO:0065003]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P24161}; Single-pass type I membrane protein.
P21108	reviewed	PRPS3_HUMAN	Ribose-phosphate pyrophosphokinase 3 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 1-like 1) (PRPS1-like 1) (Phosphoribosyl pyrophosphate synthase III) (PRS-III)	PRPS1L1 PRPS3 PRPSL	Homo sapiens (Human)	318	FUNCTION: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.		5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; male gonad development [GO:0008584]; phosphorylation [GO:0016310]; purine nucleotide biosynthetic process [GO:0006164]; ribonucleoside monophosphate biosynthetic process [GO:0009156]	cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189]	ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749]	cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; male gonad development [GO:0008584]; phosphorylation [GO:0016310]; purine nucleotide biosynthetic process [GO:0006164]; ribonucleoside monophosphate biosynthetic process [GO:0009156]	
P21127	reviewed	CD11B_HUMAN	Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)	CDK11B CDC2L1 CDK11 PITSLREA PK58	Homo sapiens (Human)	795	FUNCTION: Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}.	MISCELLANEOUS: Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.; MISCELLANEOUS: [Isoform 7]: Produced by alternative initiation at Met-357 of isoform SV9 via an internal ribosomal entry site (IRES). {ECO:0000305}.	apoptotic process [GO:0006915]; mitotic cell cycle [GO:0000278]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of centrosome cycle [GO:0046605]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of mRNA processing [GO:0050684]; regulation of RNA splicing [GO:0043484]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; mitotic cell cycle [GO:0000278]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of centrosome cycle [GO:0046605]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of mRNA processing [GO:0050684]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
P21128	reviewed	ENDOU_HUMAN	Uridylate-specific endoribonuclease (EC 4.6.1.-) (Placental protein 11) (PP11) (Protein endoU)	ENDOU	Homo sapiens (Human)	410	FUNCTION: Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end. The UU and GU sites are more efficiently cleaved than CU and AU sites. {ECO:0000269|PubMed:18936097}.		female pregnancy [GO:0007565]; immune response [GO:0006955]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	growth factor activity [GO:0008083]; lyase activity [GO:0016829]; manganese ion binding [GO:0030145]; polysaccharide binding [GO:0030247]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; scavenger receptor activity [GO:0005044]; serine-type peptidase activity [GO:0008236]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; growth factor activity [GO:0008083]; lyase activity [GO:0016829]; manganese ion binding [GO:0030145]; polysaccharide binding [GO:0030247]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; scavenger receptor activity [GO:0005044]; serine-type peptidase activity [GO:0008236]; female pregnancy [GO:0007565]; immune response [GO:0006955]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P21145	reviewed	MAL_HUMAN	Myelin and lymphocyte protein (T-lymphocyte maturation-associated protein)	MAL	Homo sapiens (Human)	153	FUNCTION: Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.		apical protein localization [GO:0045176]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; central nervous system myelination [GO:0022010]; membrane raft polarization [GO:0001766]; myelination [GO:0042552]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; protein insertion into plasma membrane [GO:0098737]; protein localization to paranode region of axon [GO:0002175]	apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; hinge region between urothelial plaques of apical plasma membrane [GO:0120003]; membrane raft [GO:0045121]; plasma membrane raft [GO:0044853]; Schmidt-Lanterman incisure [GO:0043220]	lipid binding [GO:0008289]; peptidase activator activity involved in apoptotic process [GO:0016505]; structural constituent of myelin sheath [GO:0019911]	apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; hinge region between urothelial plaques of apical plasma membrane [GO:0120003]; membrane raft [GO:0045121]; plasma membrane raft [GO:0044853]; Schmidt-Lanterman incisure [GO:0043220]; lipid binding [GO:0008289]; peptidase activator activity involved in apoptotic process [GO:0016505]; structural constituent of myelin sheath [GO:0019911]; apical protein localization [GO:0045176]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; central nervous system myelination [GO:0022010]; membrane raft polarization [GO:0001766]; myelination [GO:0042552]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; protein insertion into plasma membrane [GO:0098737]; protein localization to paranode region of axon [GO:0002175]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P21217	reviewed	FUT3_HUMAN	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (EC 2.4.1.65) (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (Alpha-3-fucosyltransferase FUT3) (EC 2.4.1.-) (Blood group Lewis alpha-4-fucosyltransferase) (Lewis FT) (Fucosyltransferase 3) (Fucosyltransferase III) (FucT-III)	FUT3 FT3B LE	Homo sapiens (Human)	361	FUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens (PubMed:12668675, PubMed:1977660, PubMed:11058871). Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration (PubMed:12668675, PubMed:11058871, PubMed:27453266). Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin (PubMed:11058871, PubMed:29593094). Prefers type 1 chain over type 2 acceptors (PubMed:7721776). Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred (PubMed:7721776). Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme (PubMed:1977660). {ECO:0000269|PubMed:11058871, ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:1977660, ECO:0000269|PubMed:27453266, ECO:0000269|PubMed:7721776}.		cell-cell recognition [GO:0009988]; ceramide metabolic process [GO:0006672]; fucosylation [GO:0036065]; macromolecule glycosylation [GO:0043413]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]; positive regulation of cell-cell adhesion [GO:0022409]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]	extracellular exosome [GO:0070062]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity [GO:0017060]; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]	extracellular exosome [GO:0070062]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity [GO:0017060]; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]; cell-cell recognition [GO:0009988]; ceramide metabolic process [GO:0006672]; fucosylation [GO:0036065]; macromolecule glycosylation [GO:0043413]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]; positive regulation of cell-cell adhesion [GO:0022409]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein {ECO:0000269|PubMed:1977660}. Note=Membrane-bound form in trans cisternae of Golgi.
P21246	reviewed	PTN_HUMAN	Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neurite outgrowth-promoting factor) (HBNF) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Osteoblast-specific factor 1) (OSF-1)	PTN HBNF1 NEGF1	Homo sapiens (Human)	168	FUNCTION: Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:16814777, PubMed:11278720, PubMed:19141530). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (PubMed:26896299, PubMed:27445335). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:1733956, PubMed:1768439, PubMed:11278720, PubMed:19141530, PubMed:27445335, PubMed:30667096, PubMed:19442624). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:17681947, PubMed:27445335, PubMed:30667096, PubMed:16814777, PubMed:10706604). Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:27445335, PubMed:30667096). Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (PubMed:19141530). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion (By similarity). Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (PubMed:11278720). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway (By similarity). Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration (By similarity). In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (By similarity). {ECO:0000250|UniProtKB:P63089, ECO:0000250|UniProtKB:P63090, ECO:0000269|PubMed:10706604, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:16814777, ECO:0000269|PubMed:1733956, ECO:0000269|PubMed:17681947, ECO:0000269|PubMed:1768439, ECO:0000269|PubMed:19141530, ECO:0000269|PubMed:19442624, ECO:0000269|PubMed:26896299, ECO:0000269|PubMed:27445335, ECO:0000269|PubMed:30667096}.		bone mineralization [GO:0030282]; decidualization [GO:0046697]; dendrite arborization [GO:0140059]; dendrite regeneration [GO:0031104]; estrous cycle [GO:0044849]; integrin-mediated signaling pathway [GO:0007229]; learning [GO:0007612]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; memory [GO:0007613]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of neuroblast proliferation [GO:0007406]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; ossification involved in bone remodeling [GO:0043932]; positive regulation of axon regeneration [GO:0048680]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite development [GO:1900006]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of neuron projection development [GO:0010976]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of ossification [GO:0045778]; positive regulation of stem cell differentiation [GO:2000738]; receptor clustering [GO:0043113]; regulation of endothelial cell migration [GO:0010594]; regulation of hemopoiesis [GO:1903706]; regulation of myelination [GO:0031641]; regulation of stem cell population maintenance [GO:2000036]; regulation of synaptic plasticity [GO:0048167]; response to auditory stimulus [GO:0010996]; tissue regeneration [GO:0042246]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]	carbohydrate binding [GO:0030246]; chondroitin sulfate binding [GO:0035374]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; molecular function activator activity [GO:0140677]; protein kinase binding [GO:0019901]; protein phosphatase inhibitor activity [GO:0004864]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]; carbohydrate binding [GO:0030246]; chondroitin sulfate binding [GO:0035374]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; molecular function activator activity [GO:0140677]; protein kinase binding [GO:0019901]; protein phosphatase inhibitor activity [GO:0004864]; bone mineralization [GO:0030282]; decidualization [GO:0046697]; dendrite arborization [GO:0140059]; dendrite regeneration [GO:0031104]; estrous cycle [GO:0044849]; integrin-mediated signaling pathway [GO:0007229]; learning [GO:0007612]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; memory [GO:0007613]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of neuroblast proliferation [GO:0007406]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; ossification involved in bone remodeling [GO:0043932]; positive regulation of axon regeneration [GO:0048680]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite development [GO:1900006]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of neuron projection development [GO:0010976]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of ossification [GO:0045778]; positive regulation of stem cell differentiation [GO:2000738]; receptor clustering [GO:0043113]; regulation of endothelial cell migration [GO:0010594]; regulation of hemopoiesis [GO:1903706]; regulation of myelination [GO:0031641]; regulation of stem cell population maintenance [GO:2000036]; regulation of synaptic plasticity [GO:0048167]; response to auditory stimulus [GO:0010996]; tissue regeneration [GO:0042246]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1733956, ECO:0000269|PubMed:8241100}.
P21266	reviewed	GSTM3_HUMAN	Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3)	GSTM3 GST5	Homo sapiens (Human)	225	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers. {ECO:0000269|PubMed:10587441}.		cellular detoxification of nitrogen compound [GO:0070458]; establishment of blood-nerve barrier [GO:0008065]; glutathione metabolic process [GO:0006749]; nitrobenzene metabolic process [GO:0018916]; response to estrogen [GO:0043627]; xenobiotic catabolic process [GO:0042178]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]	enzyme binding [GO:0019899]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]; enzyme binding [GO:0019899]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; cellular detoxification of nitrogen compound [GO:0070458]; establishment of blood-nerve barrier [GO:0008065]; glutathione metabolic process [GO:0006749]; nitrobenzene metabolic process [GO:0018916]; response to estrogen [GO:0043627]; xenobiotic catabolic process [GO:0042178]	SUBCELLULAR LOCATION: Cytoplasm.
P21281	reviewed	VATB2_HUMAN	V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2)	ATP6V1B2 ATP6B2 VPP3	Homo sapiens (Human)	511	FUNCTION: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity). {ECO:0000250|UniProtKB:P62814, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}.		ATP metabolic process [GO:0046034]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	ATP binding [GO:0005524]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]; ATP binding [GO:0005524]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP metabolic process [GO:0046034]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:29993276}. Melanosome {ECO:0000269|PubMed:12643545}. Cytoplasm {ECO:0000250|UniProtKB:P62814}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P62815}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P62815}; Peripheral membrane protein {ECO:0000305}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545}.
P21283	reviewed	VATC1_HUMAN	V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1)	ATP6V1C1 ATP6C ATP6D VATC	Homo sapiens (Human)	382	FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). {ECO:0000250|UniProtKB:P21282, ECO:0000250|UniProtKB:P31412, ECO:0000269|PubMed:33065002}.		proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]	apical part of cell [GO:0045177]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical part of cell [GO:0045177]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q5FVI6}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q5FVI6}; Peripheral membrane protein {ECO:0000305}.
P21291	reviewed	CSRP1_HUMAN	Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP) (CRP1) (Epididymis luminal protein 141) (HEL-141)	CSRP1 CSRP CYRP	Homo sapiens (Human)	193	FUNCTION: Could play a role in neuronal development.		muscle tissue development [GO:0060537]; platelet aggregation [GO:0070527]; sarcomere organization [GO:0045214]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; Z disc [GO:0030018]	actinin binding [GO:0042805]; RNA binding [GO:0003723]; structural constituent of muscle [GO:0008307]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; Z disc [GO:0030018]; actinin binding [GO:0042805]; RNA binding [GO:0003723]; structural constituent of muscle [GO:0008307]; zinc ion binding [GO:0008270]; muscle tissue development [GO:0060537]; platelet aggregation [GO:0070527]; sarcomere organization [GO:0045214]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26924529}.
P21333	reviewed	FLNA_HUMAN	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	FLNA FLN FLN1	Homo sapiens (Human)	2647	FUNCTION: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.		actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; angiogenesis [GO:0001525]; blood coagulation, intrinsic pathway [GO:0007597]; blood vessel remodeling [GO:0001974]; cell-cell junction organization [GO:0045216]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; cytoplasmic sequestering of protein [GO:0051220]; early endosome to late endosome transport [GO:0045022]; epithelial to mesenchymal transition [GO:0001837]; establishment of protein localization [GO:0045184]; establishment of Sertoli cell barrier [GO:0097368]; formation of radial glial scaffolds [GO:0021943]; heart morphogenesis [GO:0003007]; megakaryocyte development [GO:0035855]; mitotic spindle assembly [GO:0090307]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase I [GO:0016479]; platelet aggregation [GO:0070527]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of axon regeneration [GO:0048680]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuron migration [GO:2001224]; positive regulation of platelet activation [GO:0010572]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to bicellular tight junction [GO:1902396]; protein localization to cell surface [GO:0034394]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of cell migration [GO:0030334]; regulation of membrane repolarization during atrial cardiac muscle cell action potential [GO:1905000]; regulation of membrane repolarization during cardiac muscle cell action potential [GO:1905031]; release of sequestered calcium ion into cytosol [GO:0051209]; semaphorin-plexin signaling pathway [GO:0071526]; synapse organization [GO:0050808]; tubulin deacetylation [GO:0090042]; wound healing, spreading of cells [GO:0044319]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; actin filament bundle [GO:0032432]; apical dendrite [GO:0097440]; axonal growth cone [GO:0044295]; brush border [GO:0005903]; cell-cell junction [GO:0005911]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; glycoprotein Ib-IX-V complex [GO:1990779]; membrane [GO:0016020]; Myb complex [GO:0031523]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; trans-Golgi network [GO:0005802]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; DNA-binding transcription factor binding [GO:0140297]; Fc-gamma receptor I complex binding [GO:0034988]; G protein-coupled receptor binding [GO:0001664]; GTPase binding [GO:0051020]; kinase binding [GO:0019900]; potassium channel regulator activity [GO:0015459]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; actin filament bundle [GO:0032432]; apical dendrite [GO:0097440]; axonal growth cone [GO:0044295]; brush border [GO:0005903]; cell-cell junction [GO:0005911]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; glycoprotein Ib-IX-V complex [GO:1990779]; membrane [GO:0016020]; Myb complex [GO:0031523]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; trans-Golgi network [GO:0005802]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; DNA-binding transcription factor binding [GO:0140297]; Fc-gamma receptor I complex binding [GO:0034988]; G protein-coupled receptor binding [GO:0001664]; GTPase binding [GO:0051020]; kinase binding [GO:0019900]; potassium channel regulator activity [GO:0015459]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]; actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; angiogenesis [GO:0001525]; blood coagulation, intrinsic pathway [GO:0007597]; blood vessel remodeling [GO:0001974]; cell-cell junction organization [GO:0045216]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; cytoplasmic sequestering of protein [GO:0051220]; early endosome to late endosome transport [GO:0045022]; epithelial to mesenchymal transition [GO:0001837]; establishment of protein localization [GO:0045184]; establishment of Sertoli cell barrier [GO:0097368]; formation of radial glial scaffolds [GO:0021943]; heart morphogenesis [GO:0003007]; megakaryocyte development [GO:0035855]; mitotic spindle assembly [GO:0090307]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase I [GO:0016479]; platelet aggregation [GO:0070527]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of axon regeneration [GO:0048680]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuron migration [GO:2001224]; positive regulation of platelet activation [GO:0010572]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to bicellular tight junction [GO:1902396]; protein localization to cell surface [GO:0034394]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of cell migration [GO:0030334]; regulation of membrane repolarization during atrial cardiac muscle cell action potential [GO:1905000]; regulation of membrane repolarization during cardiac muscle cell action potential [GO:1905031]; release of sequestered calcium ion into cytosol [GO:0051209]; semaphorin-plexin signaling pathway [GO:0071526]; synapse organization [GO:0050808]; tubulin deacetylation [GO:0090042]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:16291724}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8BTM8}. Perikaryon {ECO:0000250|UniProtKB:Q8BTM8}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q8BTM8}. Note=Colocalizes with CPMR1 in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity). {ECO:0000250|UniProtKB:Q8BTM8}.
P21359	reviewed	NF1_HUMAN	Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated]	NF1	Homo sapiens (Human)	2839	FUNCTION: Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}.		actin cytoskeleton organization [GO:0030036]; adrenal gland development [GO:0030325]; amygdala development [GO:0021764]; angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; brain development [GO:0007420]; camera-type eye morphogenesis [GO:0048593]; cell communication [GO:0007154]; cellular response to heat [GO:0034605]; cerebral cortex development [GO:0021987]; cognition [GO:0050890]; collagen fibril organization [GO:0030199]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; fibroblast proliferation [GO:0048144]; forebrain astrocyte development [GO:0021897]; forebrain morphogenesis [GO:0048853]; gamma-aminobutyric acid secretion, neurotransmission [GO:0061534]; glutamate secretion, neurotransmission [GO:0061535]; hair follicle maturation [GO:0048820]; heart development [GO:0007507]; liver development [GO:0001889]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; mast cell apoptotic process [GO:0033024]; mast cell proliferation [GO:0070662]; metanephros development [GO:0001656]; myelination in peripheral nervous system [GO:0022011]; myeloid leukocyte migration [GO:0097529]; negative regulation of angiogenesis [GO:0016525]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of mast cell proliferation [GO:0070667]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of Rac protein signal transduction [GO:0035021]; negative regulation of Schwann cell migration [GO:1900148]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; neural tube development [GO:0021915]; neuroblast proliferation [GO:0007405]; neuron apoptotic process [GO:0051402]; observational learning [GO:0098597]; oligodendrocyte differentiation [GO:0048709]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; peripheral nervous system development [GO:0007422]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; pigmentation [GO:0043473]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mast cell apoptotic process [GO:0033027]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein import into nucleus [GO:0006606]; Rac protein signal transduction [GO:0016601]; Ras protein signal transduction [GO:0007265]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of bone resorption [GO:0045124]; regulation of cell-matrix adhesion [GO:0001952]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of gene expression [GO:0010468]; regulation of glial cell differentiation [GO:0045685]; regulation of GTPase activity [GO:0043087]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic transmission, GABAergic [GO:0032228]; response to hypoxia [GO:0001666]; Schwann cell development [GO:0014044]; Schwann cell migration [GO:0036135]; Schwann cell proliferation [GO:0014010]; skeletal muscle tissue development [GO:0007519]; smooth muscle tissue development [GO:0048745]; spinal cord development [GO:0021510]; stem cell proliferation [GO:0072089]; sympathetic nervous system development [GO:0048485]; vascular associated smooth muscle cell migration [GO:1904738]; vascular associated smooth muscle cell proliferation [GO:1990874]; visual learning [GO:0008542]; wound healing [GO:0042060]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GTPase activator activity [GO:0005096]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; GTPase activator activity [GO:0005096]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; actin cytoskeleton organization [GO:0030036]; adrenal gland development [GO:0030325]; amygdala development [GO:0021764]; angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; brain development [GO:0007420]; camera-type eye morphogenesis [GO:0048593]; cell communication [GO:0007154]; cellular response to heat [GO:0034605]; cerebral cortex development [GO:0021987]; cognition [GO:0050890]; collagen fibril organization [GO:0030199]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; fibroblast proliferation [GO:0048144]; forebrain astrocyte development [GO:0021897]; forebrain morphogenesis [GO:0048853]; gamma-aminobutyric acid secretion, neurotransmission [GO:0061534]; glutamate secretion, neurotransmission [GO:0061535]; hair follicle maturation [GO:0048820]; heart development [GO:0007507]; liver development [GO:0001889]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; mast cell apoptotic process [GO:0033024]; mast cell proliferation [GO:0070662]; metanephros development [GO:0001656]; myelination in peripheral nervous system [GO:0022011]; myeloid leukocyte migration [GO:0097529]; negative regulation of angiogenesis [GO:0016525]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of mast cell proliferation [GO:0070667]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of Rac protein signal transduction [GO:0035021]; negative regulation of Schwann cell migration [GO:1900148]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; neural tube development [GO:0021915]; neuroblast proliferation [GO:0007405]; neuron apoptotic process [GO:0051402]; observational learning [GO:0098597]; oligodendrocyte differentiation [GO:0048709]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; peripheral nervous system development [GO:0007422]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; pigmentation [GO:0043473]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mast cell apoptotic process [GO:0033027]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein import into nucleus [GO:0006606]; Rac protein signal transduction [GO:0016601]; Ras protein signal transduction [GO:0007265]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of bone resorption [GO:0045124]; regulation of cell-matrix adhesion [GO:0001952]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of gene expression [GO:0010468]; regulation of glial cell differentiation [GO:0045685]; regulation of GTPase activity [GO:0043087]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic transmission, GABAergic [GO:0032228]; response to hypoxia [GO:0001666]; Schwann cell development [GO:0014044]; Schwann cell migration [GO:0036135]; Schwann cell proliferation [GO:0014010]; skeletal muscle tissue development [GO:0007519]; smooth muscle tissue development [GO:0048745]; spinal cord development [GO:0021510]; stem cell proliferation [GO:0072089]; sympathetic nervous system development [GO:0048485]; vascular associated smooth muscle cell migration [GO:1904738]; vascular associated smooth muscle cell proliferation [GO:1990874]; visual learning [GO:0008542]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14988005}. Nucleus, nucleolus {ECO:0000269|PubMed:14988005}. Cell membrane {ECO:0000269|PubMed:34626534}.
P21397	reviewed	AOFA_HUMAN	Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A)	MAOA	Homo sapiens (Human)	527	FUNCTION: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:20493079, PubMed:8316221, PubMed:18391214, PubMed:24169519). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity). {ECO:0000250|UniProtKB:P21396, ECO:0000269|PubMed:18391214, ECO:0000269|PubMed:20493079, ECO:0000269|PubMed:24169519, ECO:0000269|PubMed:8316221}.		biogenic amine metabolic process [GO:0006576]; dopamine catabolic process [GO:0042420]; neurotransmitter catabolic process [GO:0042135]; positive regulation of signal transduction [GO:0009967]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	aliphatic amine oxidase activity [GO:0052595]; flavin adenine dinucleotide binding [GO:0050660]; monoamine oxidase activity [GO:0097621]; phenethylamine:oxygen oxidoreductase (deaminating) activity [GO:0052596]; primary amine oxidase activity [GO:0008131]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; aliphatic amine oxidase activity [GO:0052595]; flavin adenine dinucleotide binding [GO:0050660]; monoamine oxidase activity [GO:0097621]; phenethylamine:oxygen oxidoreductase (deaminating) activity [GO:0052596]; primary amine oxidase activity [GO:0008131]; biogenic amine metabolic process [GO:0006576]; dopamine catabolic process [GO:0042420]; neurotransmitter catabolic process [GO:0042135]; positive regulation of signal transduction [GO:0009967]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21396}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:P21396}; Cytoplasmic side {ECO:0000250|UniProtKB:P21396}.
P21399	reviewed	ACOHC_HUMAN	Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)	ACO1 IREB1	Homo sapiens (Human)	889	FUNCTION: Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1946430, PubMed:1281544, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:1946430, PubMed:1281544, PubMed:8041788, PubMed:23891004). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1946430, PubMed:1281544, PubMed:8041788, PubMed:23891004). {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:8041788}.; FUNCTION: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}.		citrate metabolic process [GO:0006101]; intestinal absorption [GO:0050892]; intracellular iron ion homeostasis [GO:0006879]; post-embryonic development [GO:0009791]; regulation of translation [GO:0006417]; response to iron(II) ion [GO:0010040]; tricarboxylic acid cycle [GO:0006099]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]	3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; citrate dehydratase activity [GO:0047780]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; citrate dehydratase activity [GO:0047780]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; citrate metabolic process [GO:0006101]; intestinal absorption [GO:0050892]; intracellular iron ion homeostasis [GO:0006879]; post-embryonic development [GO:0009791]; regulation of translation [GO:0006417]; response to iron(II) ion [GO:0010040]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1281544}.
P21439	reviewed	MDR3_HUMAN	Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3)	ABCB4 MDR3 PGY3	Homo sapiens (Human)	1286	FUNCTION: [Isoform 1]: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390, PubMed:31873305). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571, PubMed:28012258). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity). {ECO:0000250|UniProtKB:P21440, ECO:0000269|PubMed:17523162, ECO:0000269|PubMed:21820390, ECO:0000269|PubMed:23468132, ECO:0000269|PubMed:24045840, ECO:0000269|PubMed:24594635, ECO:0000269|PubMed:24723470, ECO:0000269|PubMed:24806754, ECO:0000269|PubMed:28012258, ECO:0000269|PubMed:31873305, ECO:0000269|PubMed:7957936, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9366571}.		bile acid secretion [GO:0032782]; cellular response to bile acid [GO:1903413]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; phospholipid translocation [GO:0045332]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of phospholipid translocation [GO:0061092]; positive regulation of phospholipid transport [GO:2001140]; response to fenofibrate [GO:1901557]; transmembrane transport [GO:0055085]	apical plasma membrane [GO:0016324]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intercellular canaliculus [GO:0046581]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; phosphatidylcholine floppase activity [GO:0090554]; phospholipid transporter activity [GO:0005548]	apical plasma membrane [GO:0016324]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intercellular canaliculus [GO:0046581]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; phosphatidylcholine floppase activity [GO:0090554]; phospholipid transporter activity [GO:0005548]; bile acid secretion [GO:0032782]; cellular response to bile acid [GO:1903413]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; phospholipid translocation [GO:0045332]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of phospholipid translocation [GO:0061092]; positive regulation of phospholipid transport [GO:2001140]; response to fenofibrate [GO:1901557]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23468132, ECO:0000269|PubMed:24045840, ECO:0000269|PubMed:24806754, ECO:0000269|PubMed:28012258}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane {ECO:0000269|PubMed:15258199, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:21820390, ECO:0000269|PubMed:24122873, ECO:0000269|PubMed:24594635, ECO:0000269|PubMed:24723470, ECO:0000269|PubMed:8898203}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Membrane raft {ECO:0000269|PubMed:23468132}. Cytoplasm {ECO:0000269|PubMed:24045840}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q08201}. Note=Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules (By similarity). Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner (PubMed:19674157). Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA-dependent manner (PubMed:15258199). Localized preferentially in lipid nonraft domains of canalicular plasma membranes (PubMed:23468132). {ECO:0000250|UniProtKB:P21440, ECO:0000269|PubMed:15258199, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:23468132}.
P21452	reviewed	NK2R_HUMAN	Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2)	TACR2 NK2R NKNAR TAC2R	Homo sapiens (Human)	398	FUNCTION: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. {ECO:0000269|PubMed:1659297}.		intestine smooth muscle contraction [GO:0014827]; muscle contraction [GO:0006936]; negative regulation of luteinizing hormone secretion [GO:0033685]; operant conditioning [GO:0035106]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of monoatomic ion transport [GO:0043270]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of uterine smooth muscle contraction [GO:0070474]; positive regulation of vascular permeability [GO:0043117]; prolactin secretion [GO:0070459]; response to electrical stimulus [GO:0051602]; tachykinin receptor signaling pathway [GO:0007217]	plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; sperm midpiece [GO:0097225]	substance K receptor activity [GO:0016497]; tachykinin receptor activity [GO:0004995]	plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; sperm midpiece [GO:0097225]; substance K receptor activity [GO:0016497]; tachykinin receptor activity [GO:0004995]; intestine smooth muscle contraction [GO:0014827]; muscle contraction [GO:0006936]; negative regulation of luteinizing hormone secretion [GO:0033685]; operant conditioning [GO:0035106]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of monoatomic ion transport [GO:0043270]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of uterine smooth muscle contraction [GO:0070474]; positive regulation of vascular permeability [GO:0043117]; prolactin secretion [GO:0070459]; response to electrical stimulus [GO:0051602]; tachykinin receptor signaling pathway [GO:0007217]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P21453	reviewed	S1PR1_HUMAN	Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363)	S1PR1 CHEDG1 EDG1	Homo sapiens (Human)	382	FUNCTION: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. {ECO:0000250, ECO:0000269|PubMed:10982820, ECO:0000269|PubMed:11230698, ECO:0000269|PubMed:11583630, ECO:0000269|PubMed:11604399, ECO:0000269|PubMed:19286607, ECO:0000269|PubMed:22344443, ECO:0000269|PubMed:8626678, ECO:0000269|PubMed:9488656}.		actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; angiogenesis [GO:0001525]; blood vessel maturation [GO:0001955]; brain development [GO:0007420]; cardiac muscle tissue growth involved in heart morphogenesis [GO:0003245]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; chemotaxis [GO:0006935]; endothelial cell differentiation [GO:0045446]; G protein-coupled receptor signaling pathway [GO:0007186]; heart trabecula morphogenesis [GO:0061384]; lamellipodium assembly [GO:0030032]; leukocyte chemotaxis [GO:0030595]; negative regulation of stress fiber assembly [GO:0051497]; neuron differentiation [GO:0030182]; positive regulation of cell migration [GO:0030335]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bone mineralization [GO:0030500]; regulation of bone resorption [GO:0045124]; regulation of cell adhesion [GO:0030155]; regulation of metabolic process [GO:0019222]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; T cell migration [GO:0072678]; transmission of nerve impulse [GO:0019226]	cytoplasm [GO:0005737]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; sphingolipid binding [GO:0046625]; sphingosine-1-phosphate receptor activity [GO:0038036]	cytoplasm [GO:0005737]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; sphingolipid binding [GO:0046625]; sphingosine-1-phosphate receptor activity [GO:0038036]; actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; angiogenesis [GO:0001525]; blood vessel maturation [GO:0001955]; brain development [GO:0007420]; cardiac muscle tissue growth involved in heart morphogenesis [GO:0003245]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; chemotaxis [GO:0006935]; endothelial cell differentiation [GO:0045446]; G protein-coupled receptor signaling pathway [GO:0007186]; heart trabecula morphogenesis [GO:0061384]; lamellipodium assembly [GO:0030032]; leukocyte chemotaxis [GO:0030595]; negative regulation of stress fiber assembly [GO:0051497]; neuron differentiation [GO:0030182]; positive regulation of cell migration [GO:0030335]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bone mineralization [GO:0030500]; regulation of bone resorption [GO:0045124]; regulation of cell adhesion [GO:0030155]; regulation of metabolic process [GO:0019222]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; T cell migration [GO:0072678]; transmission of nerve impulse [GO:0019226]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29185452}; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
P21462	reviewed	FPR1_HUMAN	fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) (FPR) (N-formylpeptide chemoattractant receptor)	FPR1	Homo sapiens (Human)	350	FUNCTION: High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520, PubMed:15210802). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (PubMed:15210802). {ECO:0000269|PubMed:10514456, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2161213, ECO:0000269|PubMed:2176894, ECO:0000269|PubMed:25109685, ECO:0000303|PubMed:10514456, ECO:0000303|PubMed:1712023, ECO:0000303|PubMed:2161213, ECO:0000303|PubMed:2176894}.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; nitric oxide mediated signal transduction [GO:0007263]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; signal transduction [GO:0007165]	azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; N-formyl peptide receptor activity [GO:0004982]; RAGE receptor binding [GO:0050786]; scavenger receptor binding [GO:0005124]	azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; N-formyl peptide receptor activity [GO:0004982]; RAGE receptor binding [GO:0050786]; scavenger receptor binding [GO:0005124]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; nitric oxide mediated signal transduction [GO:0007263]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2176894, ECO:0000269|PubMed:25109685, ECO:0000305|PubMed:10514456}; Multi-pass membrane protein {ECO:0000255}. Note=Internalizes in presence of its ligands, fMLP, TAFA4 and CTSG. {ECO:0000269|PubMed:15210802, ECO:0000269|PubMed:25109685}.
P21549	reviewed	AGT1_HUMAN	Alanine--glyoxylate aminotransferase (AGT) (EC 2.6.1.44) (Serine--pyruvate aminotransferase) (SPT) (EC 2.6.1.51)	AGXT AGT1 SPAT	Homo sapiens (Human)	392	FUNCTION: Peroxisomal aminotransferase that catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification (PubMed:10960483, PubMed:12777626, PubMed:24055001, PubMed:23229545, PubMed:26149463). Also catalyzes the transamination between L-serine and pyruvate and contributes to gluconeogenesis from the L-serine metabolism (PubMed:10347152). {ECO:0000269|PubMed:10347152, ECO:0000269|PubMed:10960483, ECO:0000269|PubMed:12777626, ECO:0000269|PubMed:23229545, ECO:0000269|PubMed:24055001, ECO:0000269|PubMed:26149463}.		glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; glyoxylate metabolic process [GO:0046487]; L-alanine catabolic process [GO:0042853]; L-cysteine catabolic process [GO:0019448]; L-serine metabolic process [GO:0006563]; Notch signaling pathway [GO:0007219]; oxalic acid secretion [GO:0046724]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	alanine-glyoxylate transaminase activity [GO:0008453]; amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]; pyridoxal phosphate binding [GO:0030170]; serine-pyruvate transaminase activity [GO:0004760]; transaminase activity [GO:0008483]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; alanine-glyoxylate transaminase activity [GO:0008453]; amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]; pyridoxal phosphate binding [GO:0030170]; serine-pyruvate transaminase activity [GO:0004760]; transaminase activity [GO:0008483]; glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; glyoxylate metabolic process [GO:0046487]; L-alanine catabolic process [GO:0042853]; L-cysteine catabolic process [GO:0019448]; L-serine metabolic process [GO:0006563]; Notch signaling pathway [GO:0007219]; oxalic acid secretion [GO:0046724]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:10960483, ECO:0000269|PubMed:12777626, ECO:0000269|PubMed:1703535, ECO:0000269|PubMed:23229545, ECO:0000269|PubMed:24055001, ECO:0000269|PubMed:26149463}.
P21554	reviewed	CNR1_HUMAN	Cannabinoid receptor 1 (CB-R) (CB1) (CANN6)	CNR1 CNR	Homo sapiens (Human)	472	FUNCTION: G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (PubMed:17895407). In cerebral vascular smooth muscle cells, cannabinoid-induced inhibition of voltage-gated Ca(2+) channels leads to vasodilation and decreased vascular tone (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes (By similarity). In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism (By similarity). In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (By similarity). In response to cannabinoid anandamide, elicits a pro-inflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712). {ECO:0000250|UniProtKB:O02777, ECO:0000250|UniProtKB:P47746, ECO:0000269|PubMed:15620723, ECO:0000269|PubMed:1718258, ECO:0000269|PubMed:17895407, ECO:0000269|PubMed:21895628, ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727}.; FUNCTION: [Isoform 1]: Binds both 2-arachidonoylglycerol (2-AG) and anandamide. {ECO:0000269|PubMed:15620723}.; FUNCTION: [Isoform 2]: Only binds 2-arachidonoylglycerol (2-AG) with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 2 in assays measuring GTP binding to membranes. {ECO:0000269|PubMed:15620723}.; FUNCTION: [Isoform 3]: Only binds 2-arachidonoylglycerol (2-AG) with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 3 in assays measuring GTP binding to membranes. {ECO:0000269|PubMed:15620723}.	MISCELLANEOUS: High-fat diet also increases the hepatic levels of CNR1 ligand anandamide, but not that of 2-arachidonoylglycerol. {ECO:0000250|UniProtKB:P47746}.; MISCELLANEOUS: [Isoform 2]: Dubious isoform. A putative downstream initiation AUG is used to produce isoform 2 (PubMed:1718258). The use of the first AUG (same as isoform 1) gives a truncated protein of 36 AA. {ECO:0000305|PubMed:1718258}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; axonal fasciculation [GO:0007413]; cannabinoid signaling pathway [GO:0038171]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose homeostasis [GO:0042593]; maternal process involved in female pregnancy [GO:0060135]; memory [GO:0007613]; negative regulation of action potential [GO:0045759]; negative regulation of blood pressure [GO:0045776]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of mast cell activation [GO:0033004]; negative regulation of serotonin secretion [GO:0014063]; positive regulation of acute inflammatory response to antigenic stimulus [GO:0002866]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood pressure [GO:0045777]; positive regulation of fever generation [GO:0031622]; positive regulation of neuron projection development [GO:0010976]; regulation of feeding behavior [GO:0060259]; regulation of insulin secretion [GO:0050796]; regulation of metabolic process [GO:0019222]; regulation of penile erection [GO:0060405]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic transmission, GABAergic [GO:0032228]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to nutrient [GO:0007584]; retrograde trans-synaptic signaling by endocannabinoid [GO:0098921]; spermatogenesis [GO:0007283]; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	cannabinoid receptor activity [GO:0004949]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; cannabinoid receptor activity [GO:0004949]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; axonal fasciculation [GO:0007413]; cannabinoid signaling pathway [GO:0038171]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose homeostasis [GO:0042593]; maternal process involved in female pregnancy [GO:0060135]; memory [GO:0007613]; negative regulation of action potential [GO:0045759]; negative regulation of blood pressure [GO:0045776]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of mast cell activation [GO:0033004]; negative regulation of serotonin secretion [GO:0014063]; positive regulation of acute inflammatory response to antigenic stimulus [GO:0002866]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood pressure [GO:0045777]; positive regulation of fever generation [GO:0031622]; positive regulation of neuron projection development [GO:0010976]; regulation of feeding behavior [GO:0060259]; regulation of insulin secretion [GO:0050796]; regulation of metabolic process [GO:0019222]; regulation of penile erection [GO:0060405]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic transmission, GABAergic [GO:0032228]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to nutrient [GO:0007584]; retrograde trans-synaptic signaling by endocannabinoid [GO:0098921]; spermatogenesis [GO:0007283]; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21895628}; Multi-pass membrane protein {ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727}. Membrane raft {ECO:0000269|PubMed:21895628}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P47746}. Cell projection, axon {ECO:0000250|UniProtKB:P20272}. Presynapse {ECO:0000250|UniProtKB:P20272}. Note=Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular. In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic (By similarity). Found on presynaptic axon terminals in some GABAergic neurons in the somatosensory cortex (By similarity). {ECO:0000250|UniProtKB:P20272, ECO:0000250|UniProtKB:P47746}.
P21579	reviewed	SYT1_HUMAN	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65)	SYT1 SVP65 SYT	Homo sapiens (Human)	422	FUNCTION: Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P46096, ECO:0000269|PubMed:23999003}.		calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; detection of calcium ion [GO:0005513]; fast, calcium ion-dependent exocytosis of neurotransmitter [GO:0098746]; neurotransmitter secretion [GO:0007269]; positive regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903235]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of synaptic transmission [GO:0050806]; protein heterooligomerization [GO:0051291]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; regulation of exocytosis [GO:0017157]; regulation of regulated secretory pathway [GO:1903305]; regulation of synaptic transmission, glutamatergic [GO:0051966]; spontaneous neurotransmitter secretion [GO:0061669]; synaptic vesicle endocytosis [GO:0048488]; synchronous neurotransmitter secretion [GO:0071911]; vesicle docking [GO:0048278]	axon [GO:0030424]; chromaffin granule membrane [GO:0042584]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-sculpted acetylcholine transport vesicle membrane [GO:0060201]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; cytoplasm [GO:0005737]; dense core granule [GO:0031045]; excitatory synapse [GO:0060076]; exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]; syntaxin-3 binding [GO:0030348]	axon [GO:0030424]; chromaffin granule membrane [GO:0042584]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-sculpted acetylcholine transport vesicle membrane [GO:0060201]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; cytoplasm [GO:0005737]; dense core granule [GO:0031045]; excitatory synapse [GO:0060076]; exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]; syntaxin-3 binding [GO:0030348]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; detection of calcium ion [GO:0005513]; fast, calcium ion-dependent exocytosis of neurotransmitter [GO:0098746]; neurotransmitter secretion [GO:0007269]; positive regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903235]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of synaptic transmission [GO:0050806]; protein heterooligomerization [GO:0051291]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; regulation of exocytosis [GO:0017157]; regulation of regulated secretory pathway [GO:1903305]; regulation of synaptic transmission, glutamatergic [GO:0051966]; spontaneous neurotransmitter secretion [GO:0061669]; synaptic vesicle endocytosis [GO:0048488]; synchronous neurotransmitter secretion [GO:0071911]; vesicle docking [GO:0048278]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasm {ECO:0000250|UniProtKB:P21707}.
P21580	reviewed	TNAP3_HUMAN	Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37]	TNFAIP3 OTUD7C	Homo sapiens (Human)	790	FUNCTION: Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages. {ECO:0000269|PubMed:14748687, ECO:0000269|PubMed:15258597, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17961127, ECO:0000269|PubMed:18164316, ECO:0000269|PubMed:18952128, ECO:0000269|PubMed:19494296, ECO:0000269|PubMed:22099304, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:8692885, ECO:0000269|PubMed:9299557, ECO:0000269|PubMed:9882303}.		apoptotic process [GO:0006915]; B-1 B cell homeostasis [GO:0001922]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; cytoskeleton organization [GO:0007010]; establishment of protein localization to vacuole [GO:0072666]; inflammatory response [GO:0006954]; negative regulation of B cell activation [GO:0050869]; negative regulation of bone resorption [GO:0045779]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of CD40 signaling pathway [GO:2000349]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070429]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of osteoclast proliferation [GO:0090291]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of toll-like receptor 5 signaling pathway [GO:0034148]; negative regulation of tumor necrosis factor production [GO:0032720]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked deubiquitination [GO:0070536]; regulation of defense response to virus by host [GO:0050691]; regulation of germinal center formation [GO:0002634]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; regulation of vascular wound healing [GO:0061043]; response to molecule of bacterial origin [GO:0002237]; response to muramyl dipeptide [GO:0032495]; tolerance induction to lipopolysaccharide [GO:0072573]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; K63-linked deubiquitinase activity [GO:0061578]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein self-association [GO:0043621]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; K63-linked deubiquitinase activity [GO:0061578]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein self-association [GO:0043621]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; B-1 B cell homeostasis [GO:0001922]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; cytoskeleton organization [GO:0007010]; establishment of protein localization to vacuole [GO:0072666]; inflammatory response [GO:0006954]; negative regulation of B cell activation [GO:0050869]; negative regulation of bone resorption [GO:0045779]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of CD40 signaling pathway [GO:2000349]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070429]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of osteoclast proliferation [GO:0090291]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of toll-like receptor 5 signaling pathway [GO:0034148]; negative regulation of tumor necrosis factor production [GO:0032720]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked deubiquitination [GO:0070536]; regulation of defense response to virus by host [GO:0050691]; regulation of germinal center formation [GO:0002634]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; regulation of vascular wound healing [GO:0061043]; response to molecule of bacterial origin [GO:0002237]; response to muramyl dipeptide [GO:0032495]; tolerance induction to lipopolysaccharide [GO:0072573]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Lysosome.; SUBCELLULAR LOCATION: [A20p50]: Cytoplasm.
P21583	reviewed	SCF_HUMAN	Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]	KITLG MGF SCF	Homo sapiens (Human)	273	FUNCTION: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.		cell adhesion [GO:0007155]; ectopic germ cell programmed cell death [GO:0035234]; embryonic hemopoiesis [GO:0035162]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; hematopoietic progenitor cell differentiation [GO:0002244]; male gonad development [GO:0008584]; mast cell apoptotic process [GO:0033024]; mast cell migration [GO:0097531]; mast cell proliferation [GO:0070662]; melanocyte migration [GO:0097324]; myeloid leukocyte differentiation [GO:0002573]; negative regulation of mast cell apoptotic process [GO:0033026]; neural crest cell migration [GO:0001755]; ovarian follicle development [GO:0001541]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of myeloid leukocyte differentiation [GO:0002763]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of T cell proliferation [GO:0042102]; Ras protein signal transduction [GO:0007265]; response to organic cyclic compound [GO:0014070]; T cell proliferation [GO:0042098]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; stem cell factor receptor binding [GO:0005173]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; stem cell factor receptor binding [GO:0005173]; cell adhesion [GO:0007155]; ectopic germ cell programmed cell death [GO:0035234]; embryonic hemopoiesis [GO:0035162]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; hematopoietic progenitor cell differentiation [GO:0002244]; male gonad development [GO:0008584]; mast cell apoptotic process [GO:0033024]; mast cell migration [GO:0097531]; mast cell proliferation [GO:0070662]; melanocyte migration [GO:0097324]; myeloid leukocyte differentiation [GO:0002573]; negative regulation of mast cell apoptotic process [GO:0033026]; neural crest cell migration [GO:0001755]; ovarian follicle development [GO:0001541]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of myeloid leukocyte differentiation [GO:0002763]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of T cell proliferation [GO:0042102]; Ras protein signal transduction [GO:0007265]; response to organic cyclic compound [GO:0014070]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:26522471}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:26522471}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000269|PubMed:26522471}. Cell projection, filopodium {ECO:0000269|PubMed:26522471}.; SUBCELLULAR LOCATION: [Soluble KIT ligand]: Secreted.
P21589	reviewed	5NTD_HUMAN	5'-nucleotidase (5'-NT) (EC 3.1.3.35) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.91) (EC 3.1.3.99) (5'-deoxynucleotidase) (Ecto-5'-nucleotidase) (IMP-specific 5'-nucleotidase) (Thymidylate 5'-phosphatase) (CD antigen CD73)	NT5E NT5 NTE	Homo sapiens (Human)	574	FUNCTION: Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate (PubMed:21933152, PubMed:34403084, PubMed:24887587, PubMed:22997138, PubMed:23142347). Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms (PubMed:34403084). Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN (PubMed:21933152, PubMed:34403084, PubMed:24887587, PubMed:22997138, PubMed:23142347). {ECO:0000269|PubMed:21933152, ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubMed:24887587, ECO:0000269|PubMed:34403084}.		adenosine biosynthetic process [GO:0046086]; ADP catabolic process [GO:0046032]; AMP catabolic process [GO:0006196]; ATP metabolic process [GO:0046034]; calcium ion homeostasis [GO:0055074]; DNA metabolic process [GO:0006259]; inhibition of non-skeletal tissue mineralization [GO:0140928]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of inflammatory response [GO:0050728]; response to ATP [GO:0033198]; response to inorganic substance [GO:0010035]	cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	5'-deoxynucleotidase activity [GO:0002953]; 5'-nucleotidase activity [GO:0008253]; GMP 5'-nucleotidase activity [GO:0050484]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; nucleotide binding [GO:0000166]; thymidylate 5'-phosphatase activity [GO:0050340]; XMP 5'-nucleosidase activity [GO:0106411]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; 5'-deoxynucleotidase activity [GO:0002953]; 5'-nucleotidase activity [GO:0008253]; GMP 5'-nucleotidase activity [GO:0050484]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; nucleotide binding [GO:0000166]; thymidylate 5'-phosphatase activity [GO:0050340]; XMP 5'-nucleosidase activity [GO:0106411]; zinc ion binding [GO:0008270]; adenosine biosynthetic process [GO:0046086]; ADP catabolic process [GO:0046032]; AMP catabolic process [GO:0006196]; ATP metabolic process [GO:0046034]; calcium ion homeostasis [GO:0055074]; DNA metabolic process [GO:0006259]; inhibition of non-skeletal tissue mineralization [GO:0140928]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of inflammatory response [GO:0050728]; response to ATP [GO:0033198]; response to inorganic substance [GO:0010035]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2129526, ECO:0000269|PubMed:24887587}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2129526}.
P21673	reviewed	SAT1_HUMAN	Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1)	SAT1 SAT	Homo sapiens (Human)	171	FUNCTION: Enzyme which catalyzes the acetylation of polyamines (PubMed:15283699, PubMed:16455797, PubMed:17516632). Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine (PubMed:17516632). This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (PubMed:16455797). Also involved in the regulation of polyamine transport out of cells (PubMed:16455797). Also acts on 1,3-diaminopropane and 1,5-diaminopentane (PubMed:16455797, PubMed:17516632). {ECO:0000269|PubMed:15283699, ECO:0000269|PubMed:16455797, ECO:0000269|PubMed:17516632}.		angiogenesis [GO:0001525]; polyamine biosynthetic process [GO:0006596]; putrescine catabolic process [GO:0009447]; spermidine acetylation [GO:0032918]	cytosol [GO:0005829]	diamine N-acetyltransferase activity [GO:0004145]; identical protein binding [GO:0042802]; N-acetyltransferase activity [GO:0008080]; spermidine binding [GO:0019809]	cytosol [GO:0005829]; diamine N-acetyltransferase activity [GO:0004145]; identical protein binding [GO:0042802]; N-acetyltransferase activity [GO:0008080]; spermidine binding [GO:0019809]; angiogenesis [GO:0001525]; polyamine biosynthetic process [GO:0006596]; putrescine catabolic process [GO:0009447]; spermidine acetylation [GO:0032918]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:1985966, ECO:0000305|PubMed:2241897}.
P21675	reviewed	TAF1_HUMAN	Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)	TAF1 BA2R CCG1 CCGS TAF2A	Homo sapiens (Human)	1893	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly (PubMed:25412659, PubMed:27007846, PubMed:33795473). TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2 (PubMed:33795473). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors (PubMed:25412659, PubMed:8625415). Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53 (PubMed:25412659). Phosphorylates GTF2A1 and GTF2F1 on Ser residues (PubMed:25412659). Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300). {ECO:0000269|PubMed:11278496, ECO:0000269|PubMed:15053879, ECO:0000269|PubMed:15870300, ECO:0000269|PubMed:2038334, ECO:0000269|PubMed:25412659, ECO:0000269|PubMed:27007846, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:8450888, ECO:0000269|PubMed:8625415, ECO:0000269|PubMed:9660973, ECO:0000269|PubMed:9858607}.	MISCELLANEOUS: [Isoform 16]: May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2a]: May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable). {ECO:0000305, ECO:0000305|PubMed:17952504}.; MISCELLANEOUS: [Isoform 2c]: May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable). {ECO:0000305, ECO:0000305|PubMed:17952504}.; MISCELLANEOUS: [Isoform 2d]: May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable). {ECO:0000305, ECO:0000305|PubMed:17952504}.; MISCELLANEOUS: [Isoform 2e]: May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable). {ECO:0000305, ECO:0000305|PubMed:17952504}.; MISCELLANEOUS: [Isoform 2h]: May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable). {ECO:0000305, ECO:0000305|PubMed:17952504}.; MISCELLANEOUS: [Isoform 2i]: May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable). {ECO:0000305, ECO:0000305|PubMed:17952504}.; MISCELLANEOUS: [Isoform 2g]: Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable). {ECO:0000305|PubMed:17952504}.; MISCELLANEOUS: [Isoform 15]: May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform N-TAF1]: Only detected in brain, highest expression in the caudate nucleus. {ECO:0000305}.	cell cycle [GO:0007049]; cellular response to ATP [GO:0071318]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; midbrain development [GO:0030901]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of gene expression [GO:0010629]; negative regulation of protein autoubiquitination [GO:1905524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of androgen receptor activity [GO:2000825]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of signal transduction by p53 class mediator [GO:1901796]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase I promoter [GO:0006361]; transcription initiation at RNA polymerase II promoter [GO:0006367]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription regulator complex [GO:0005667]	ATP binding [GO:0005524]; histone acetyltransferase activity [GO:0004402]; kinase activity [GO:0016301]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; TBP-class protein binding [GO:0017025]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin conjugating enzyme activity [GO:0061631]	chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription regulator complex [GO:0005667]; ATP binding [GO:0005524]; histone acetyltransferase activity [GO:0004402]; kinase activity [GO:0016301]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; TBP-class protein binding [GO:0017025]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin conjugating enzyme activity [GO:0061631]; cell cycle [GO:0007049]; cellular response to ATP [GO:0071318]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; midbrain development [GO:0030901]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of gene expression [GO:0010629]; negative regulation of protein autoubiquitination [GO:1905524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of androgen receptor activity [GO:2000825]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of signal transduction by p53 class mediator [GO:1901796]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase I promoter [GO:0006361]; transcription initiation at RNA polymerase II promoter [GO:0006367]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:2038334, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:27007846}.
P21695	reviewed	GPDA_HUMAN	Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)	GPD1	Homo sapiens (Human)	349	FUNCTION: Has glycerol-3-phosphate dehydrogenase activity. {ECO:0000269|PubMed:7772607}.		cellular response to cAMP [GO:0071320]; cellular response to tumor necrosis factor [GO:0071356]; gluconeogenesis [GO:0006094]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerolipid metabolic process [GO:0046486]; glycerophosphate shuttle [GO:0006127]; NADH metabolic process [GO:0006734]; NADH oxidation [GO:0006116]; positive regulation of glycolytic process [GO:0045821]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycerol-3-phosphate dehydrogenase complex [GO:0009331]	glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]; glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952]; NAD binding [GO:0051287]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycerol-3-phosphate dehydrogenase complex [GO:0009331]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]; glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952]; NAD binding [GO:0051287]; protein homodimerization activity [GO:0042803]; cellular response to cAMP [GO:0071320]; cellular response to tumor necrosis factor [GO:0071356]; gluconeogenesis [GO:0006094]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerolipid metabolic process [GO:0046486]; glycerophosphate shuttle [GO:0006127]; NADH metabolic process [GO:0006734]; NADH oxidation [GO:0006116]; positive regulation of glycolytic process [GO:0045821]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7772607}.
P21709	reviewed	EPHA1_HUMAN	Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)	EPHA1 EPH EPHT EPHT1	Homo sapiens (Human)	976	FUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. {ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:19118217, ECO:0000269|PubMed:20043122}.		activation of GTPase activity [GO:0090630]; angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of cell migration [GO:0030336]; negative regulation of protein kinase activity [GO:0006469]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of stress fiber assembly [GO:0051496]; protein autophosphorylation [GO:0046777]; regulation of GTPase activity [GO:0043087]; substrate adhesion-dependent cell spreading [GO:0034446]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; fibronectin binding [GO:0001968]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; fibronectin binding [GO:0001968]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; activation of GTPase activity [GO:0090630]; angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of cell migration [GO:0030336]; negative regulation of protein kinase activity [GO:0006469]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of stress fiber assembly [GO:0051496]; protein autophosphorylation [GO:0046777]; regulation of GTPase activity [GO:0043087]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19118217}; Single-pass type I membrane protein {ECO:0000269|PubMed:19118217}.
P21728	reviewed	DRD1_HUMAN	D(1A) dopamine receptor (Dopamine D1 receptor)	DRD1	Homo sapiens (Human)	446	FUNCTION: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.		activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adult walking behavior [GO:0007628]; astrocyte development [GO:0014002]; behavioral fear response [GO:0001662]; behavioral response to cocaine [GO:0048148]; cellular response to catecholamine stimulus [GO:0071870]; cerebral cortex GABAergic interneuron migration [GO:0021853]; conditioned taste aversion [GO:0001661]; dentate gyrus development [GO:0021542]; dopamine metabolic process [GO:0042417]; dopamine receptor signaling pathway [GO:0007212]; dopamine transport [GO:0015872]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose import [GO:0046323]; grooming behavior [GO:0007625]; habituation [GO:0046959]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; maternal behavior [GO:0042711]; mating behavior [GO:0007617]; memory [GO:0007613]; modification of postsynaptic structure [GO:0099010]; neuronal action potential [GO:0019228]; operant conditioning [GO:0035106]; peristalsis [GO:0030432]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell migration [GO:0030335]; positive regulation of neuron migration [GO:2001224]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein import into nucleus [GO:0006606]; regulation of dopamine metabolic process [GO:0042053]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of protein phosphorylation [GO:0001932]; response to amphetamine [GO:0001975]; response to xenobiotic stimulus [GO:0009410]; sensitization [GO:0046960]; striatum development [GO:0021756]; synapse assembly [GO:0007416]; synaptic transmission, glutamatergic [GO:0035249]; temperature homeostasis [GO:0001659]; transmission of nerve impulse [GO:0019226]; vasodilation [GO:0042311]; visual learning [GO:0008542]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; G protein-coupled receptor complex [GO:0097648]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	arrestin family protein binding [GO:1990763]; dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity [GO:0004952]; dopamine neurotransmitter receptor activity, coupled via Gs [GO:0001588]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; heterotrimeric G-protein binding [GO:0032795]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; G protein-coupled receptor complex [GO:0097648]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; arrestin family protein binding [GO:1990763]; dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity [GO:0004952]; dopamine neurotransmitter receptor activity, coupled via Gs [GO:0001588]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; heterotrimeric G-protein binding [GO:0032795]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adult walking behavior [GO:0007628]; astrocyte development [GO:0014002]; behavioral fear response [GO:0001662]; behavioral response to cocaine [GO:0048148]; cellular response to catecholamine stimulus [GO:0071870]; cerebral cortex GABAergic interneuron migration [GO:0021853]; conditioned taste aversion [GO:0001661]; dentate gyrus development [GO:0021542]; dopamine metabolic process [GO:0042417]; dopamine receptor signaling pathway [GO:0007212]; dopamine transport [GO:0015872]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose import [GO:0046323]; grooming behavior [GO:0007625]; habituation [GO:0046959]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; maternal behavior [GO:0042711]; mating behavior [GO:0007617]; memory [GO:0007613]; modification of postsynaptic structure [GO:0099010]; neuronal action potential [GO:0019228]; operant conditioning [GO:0035106]; peristalsis [GO:0030432]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell migration [GO:0030335]; positive regulation of neuron migration [GO:2001224]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein import into nucleus [GO:0006606]; regulation of dopamine metabolic process [GO:0042053]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of protein phosphorylation [GO:0001932]; response to amphetamine [GO:0001975]; response to xenobiotic stimulus [GO:0009410]; sensitization [GO:0046960]; striatum development [GO:0021756]; synapse assembly [GO:0007416]; synaptic transmission, glutamatergic [GO:0035249]; temperature homeostasis [GO:0001659]; transmission of nerve impulse [GO:0019226]; vasodilation [GO:0042311]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18901}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18901}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q61616}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q61616}. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250|UniProtKB:P18901}.
P21730	reviewed	C5AR1_HUMAN	C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88)	C5AR1 C5AR C5R1	Homo sapiens (Human)	350	FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:29300009, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}.		activation of phospholipase C activity [GO:0007202]; amyloid-beta clearance [GO:0097242]; astrocyte activation [GO:0048143]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; cognition [GO:0050890]; complement component C5a signaling pathway [GO:0038178]; complement receptor mediated signaling pathway [GO:0002430]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; inflammatory response [GO:0006954]; microglial cell activation [GO:0001774]; mRNA transcription by RNA polymerase II [GO:0042789]; neutrophil chemotaxis [GO:0030593]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of vascular endothelial growth factor production [GO:0010575]; presynapse organization [GO:0099172]; regulation of tau-protein kinase activity [GO:1902947]; response to peptidoglycan [GO:0032494]; sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165]	apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	complement component C5a receptor activity [GO:0004878]; G protein-coupled receptor activity [GO:0004930]	apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; complement component C5a receptor activity [GO:0004878]; G protein-coupled receptor activity [GO:0004930]; activation of phospholipase C activity [GO:0007202]; amyloid-beta clearance [GO:0097242]; astrocyte activation [GO:0048143]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; cognition [GO:0050890]; complement component C5a signaling pathway [GO:0038178]; complement receptor mediated signaling pathway [GO:0002430]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; inflammatory response [GO:0006954]; microglial cell activation [GO:0001774]; mRNA transcription by RNA polymerase II [GO:0042789]; neutrophil chemotaxis [GO:0030593]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of vascular endothelial growth factor production [GO:0010575]; presynapse organization [GO:0099172]; regulation of tau-protein kinase activity [GO:1902947]; response to peptidoglycan [GO:0032494]; sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12464600, ECO:0000269|PubMed:29300009}; Multi-pass membrane protein {ECO:0000269|PubMed:29300009}. Cytoplasmic vesicle {ECO:0000269|PubMed:12464600}. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000269|PubMed:12464600}.
P21731	reviewed	TA2R_HUMAN	Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)	TBXA2R	Homo sapiens (Human)	343	FUNCTION: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. {ECO:0000269|PubMed:8613548}.; FUNCTION: [Isoform 1]: Activates adenylyl cyclase. {ECO:0000269|PubMed:8613548}.; FUNCTION: [Isoform 2]: Inhibits adenylyl cyclase. {ECO:0000269|PubMed:8613548}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to lipopolysaccharide [GO:0071222]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of vasoconstriction [GO:0045907]; response to ethanol [GO:0045471]; response to nutrient [GO:0007584]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; second-messenger-mediated signaling [GO:0019932]; smooth muscle contraction [GO:0006939]	acrosomal vesicle [GO:0001669]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; thromboxane A2 receptor activity [GO:0004961]	acrosomal vesicle [GO:0001669]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; thromboxane A2 receptor activity [GO:0004961]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to lipopolysaccharide [GO:0071222]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of vasoconstriction [GO:0045907]; response to ethanol [GO:0045471]; response to nutrient [GO:0007584]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; second-messenger-mediated signaling [GO:0019932]; smooth muscle contraction [GO:0006939]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P21741	reviewed	MK_HUMAN	Midkine (MK) (Amphiregulin-associated protein) (ARAP) (Midgestation and kidney protein) (Neurite outgrowth-promoting factor 2) (Neurite outgrowth-promoting protein)	MDK MK1 NEGF2	Homo sapiens (Human)	143	FUNCTION: Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:18469519, PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:24458438, PubMed:15466886, PubMed:12084985, PubMed:10772929). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:12084985, PubMed:10212223). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:10683378, PubMed:24458438, PubMed:22323540, PubMed:12084985, PubMed:15466886, PubMed:10772929). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:24458438). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:22323540). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (PubMed:10212223). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (PubMed:12084985, PubMed:1768439). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:12084985). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886, PubMed:1768439). Binds LRP1; promotes neuronal survival (PubMed:10772929). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (PubMed:12122009). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (PubMed:18469519). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity). {ECO:0000250|UniProtKB:P12025, ECO:0000250|UniProtKB:Q9R1S9, ECO:0000269|PubMed:10212223, ECO:0000269|PubMed:10683378, ECO:0000269|PubMed:10772929, ECO:0000269|PubMed:12084985, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:12573468, ECO:0000269|PubMed:15466886, ECO:0000269|PubMed:1768439, ECO:0000269|PubMed:18469519, ECO:0000269|PubMed:22323540, ECO:0000269|PubMed:24458438}.	MISCELLANEOUS: [Isoform 2]: Found in cancer tissues with expression in the tumor bodies and surrounding normal cells. {ECO:0000305}.	adrenal gland development [GO:0030325]; behavioral fear response [GO:0001662]; cell differentiation [GO:0030154]; cerebellar granular layer development [GO:0021681]; cerebral cortex development [GO:0021987]; cytoskeleton organization [GO:0007010]; defecation [GO:0030421]; dentate gyrus development [GO:0021542]; estrous cycle [GO:0044849]; glial cell projection elongation [GO:0106091]; intracellular signal transduction [GO:0035556]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell adhesion [GO:0007162]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of regulatory T cell differentiation [GO:0045590]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of blood vessel branching [GO:1905555]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of inflammatory response [GO:0050729]; positive regulation of inflammatory response to wounding [GO:0106016]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of leukocyte cell-cell adhesion [GO:1903039]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of behavior [GO:0050795]; regulation of bone remodeling [GO:0046850]; regulation of chondrocyte differentiation [GO:0032330]; response to auditory stimulus [GO:0010996]; response to wounding [GO:0009611]; short-term memory [GO:0007614]; signal transduction [GO:0007165]; T cell activation involved in immune response [GO:0002286]; tissue regeneration [GO:0042246]	extracellular region [GO:0005576]	chondroitin sulfate binding [GO:0035374]; growth factor activity [GO:0008083]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]	extracellular region [GO:0005576]; chondroitin sulfate binding [GO:0035374]; growth factor activity [GO:0008083]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; adrenal gland development [GO:0030325]; behavioral fear response [GO:0001662]; cell differentiation [GO:0030154]; cerebellar granular layer development [GO:0021681]; cerebral cortex development [GO:0021987]; cytoskeleton organization [GO:0007010]; defecation [GO:0030421]; dentate gyrus development [GO:0021542]; estrous cycle [GO:0044849]; glial cell projection elongation [GO:0106091]; intracellular signal transduction [GO:0035556]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell adhesion [GO:0007162]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of regulatory T cell differentiation [GO:0045590]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of blood vessel branching [GO:1905555]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of inflammatory response [GO:0050729]; positive regulation of inflammatory response to wounding [GO:0106016]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of leukocyte cell-cell adhesion [GO:1903039]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of behavior [GO:0050795]; regulation of bone remodeling [GO:0046850]; regulation of chondrocyte differentiation [GO:0032330]; response to auditory stimulus [GO:0010996]; response to wounding [GO:0009611]; short-term memory [GO:0007614]; signal transduction [GO:0007165]; T cell activation involved in immune response [GO:0002286]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Secreted.
P21754	reviewed	ZP3_HUMAN	Zona pellucida sperm-binding protein 3 (Sperm receptor) (ZP3A/ZP3B) (Zona pellucida glycoprotein 3) (Zp-3) (Zona pellucida protein C) [Cleaved into: Processed zona pellucida sperm-binding protein 3]	ZP3 ZP3A ZP3B ZPC	Homo sapiens (Human)	424	FUNCTION: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.	MISCELLANEOUS: [Isoform ZP3B]: Found in a second polymorphic locus which, due to an extra G residue in exon 8, has the potential to encode a truncated protein of 372 amino acids. {ECO:0000305}.	binding of sperm to zona pellucida [GO:0007339]; blastocyst formation [GO:0001825]; egg coat formation [GO:0035803]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; negative regulation of DNA-templated transcription [GO:0045892]; oocyte development [GO:0048599]; positive regulation of acrosomal vesicle exocytosis [GO:2000368]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of humoral immune response [GO:0002922]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]; positive regulation of type IV hypersensitivity [GO:0001809]	collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	acrosin binding [GO:0032190]; carbohydrate binding [GO:0030246]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018]; structural constituent of egg coat [GO:0035804]	collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; acrosin binding [GO:0032190]; carbohydrate binding [GO:0030246]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018]; structural constituent of egg coat [GO:0035804]; binding of sperm to zona pellucida [GO:0007339]; blastocyst formation [GO:0001825]; egg coat formation [GO:0035803]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; negative regulation of DNA-templated transcription [GO:0045892]; oocyte development [GO:0048599]; positive regulation of acrosomal vesicle exocytosis [GO:2000368]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of humoral immune response [GO:0002922]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]; positive regulation of type IV hypersensitivity [GO:0001809]	SUBCELLULAR LOCATION: [Processed zona pellucida sperm-binding protein 3]: Zona pellucida {ECO:0000269|PubMed:29895852}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48833}; Single-pass type I membrane protein {ECO:0000255}.
P21757	reviewed	MSRE_HUMAN	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204)	MSR1 SCARA1	Homo sapiens (Human)	451	FUNCTION: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586). {ECO:0000269|PubMed:2251254, ECO:0000269|PubMed:9548586}.	MISCELLANEOUS: [Isoform II]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	amyloid-beta clearance [GO:0097242]; cellular response to organic cyclic compound [GO:0071407]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; lipoprotein transport [GO:0042953]; negative regulation of gene expression [GO:0010629]; phagocytosis, engulfment [GO:0006911]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; receptor-mediated endocytosis [GO:0006898]	collagen trimer [GO:0005581]; endocytic vesicle membrane [GO:0030666]; low-density lipoprotein particle [GO:0034362]; membrane [GO:0016020]; plasma membrane [GO:0005886]	amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; low-density lipoprotein particle binding [GO:0030169]; scavenger receptor activity [GO:0005044]	collagen trimer [GO:0005581]; endocytic vesicle membrane [GO:0030666]; low-density lipoprotein particle [GO:0034362]; membrane [GO:0016020]; plasma membrane [GO:0005886]; amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; low-density lipoprotein particle binding [GO:0030169]; scavenger receptor activity [GO:0005044]; amyloid-beta clearance [GO:0097242]; cellular response to organic cyclic compound [GO:0071407]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; lipoprotein transport [GO:0042953]; negative regulation of gene expression [GO:0010629]; phagocytosis, engulfment [GO:0006911]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
P21781	reviewed	FGF7_HUMAN	Fibroblast growth factor 7 (FGF-7) (Heparin-binding growth factor 7) (HBGF-7) (Keratinocyte growth factor)	FGF7 KGF	Homo sapiens (Human)	194	FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:8663044}.		actin cytoskeleton organization [GO:0030036]; animal organ morphogenesis [GO:0009887]; branching involved in salivary gland morphogenesis [GO:0060445]; cell differentiation [GO:0030154]; endothelial cell proliferation [GO:0001935]; epidermis development [GO:0008544]; fibroblast growth factor receptor signaling pathway [GO:0008543]; hair follicle morphogenesis [GO:0031069]; lung development [GO:0030324]; mesenchymal cell proliferation [GO:0010463]; myoblast proliferation [GO:0051450]; positive chemotaxis [GO:0050918]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein localization to cell surface [GO:0034394]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of cell migration [GO:0030334]; response to wounding [GO:0009611]; secretion by lung epithelial cell involved in lung growth [GO:0061033]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]	chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; type 2 fibroblast growth factor receptor binding [GO:0005111]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; type 2 fibroblast growth factor receptor binding [GO:0005111]; actin cytoskeleton organization [GO:0030036]; animal organ morphogenesis [GO:0009887]; branching involved in salivary gland morphogenesis [GO:0060445]; cell differentiation [GO:0030154]; endothelial cell proliferation [GO:0001935]; epidermis development [GO:0008544]; fibroblast growth factor receptor signaling pathway [GO:0008543]; hair follicle morphogenesis [GO:0031069]; lung development [GO:0030324]; mesenchymal cell proliferation [GO:0010463]; myoblast proliferation [GO:0051450]; positive chemotaxis [GO:0050918]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein localization to cell surface [GO:0034394]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of cell migration [GO:0030334]; response to wounding [GO:0009611]; secretion by lung epithelial cell involved in lung growth [GO:0061033]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P21796	reviewed	VDAC1_HUMAN	Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)	VDAC1 VDAC	Homo sapiens (Human)	283	FUNCTION: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). {ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.		apoptotic process [GO:0006915]; behavioral fear response [GO:0001662]; epithelial cell differentiation [GO:0030855]; learning [GO:0007612]; monoatomic anion transport [GO:0006820]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcium import into the mitochondrion [GO:0110099]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neuron-neuron synaptic transmission [GO:0007270]; positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:1905091]; pyruvate metabolic process [GO:0006090]; regulation of autophagy of mitochondrion [GO:1903146]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; synapse [GO:0045202]	ceramide binding [GO:0097001]; cholesterol binding [GO:0015485]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]; porin activity [GO:0015288]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic anion channel activity [GO:0008308]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; synapse [GO:0045202]; ceramide binding [GO:0097001]; cholesterol binding [GO:0015485]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]; porin activity [GO:0015288]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic anion channel activity [GO:0008308]; apoptotic process [GO:0006915]; behavioral fear response [GO:0001662]; epithelial cell differentiation [GO:0030855]; learning [GO:0007612]; monoatomic anion transport [GO:0006820]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcium import into the mitochondrion [GO:0110099]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neuron-neuron synaptic transmission [GO:0007270]; positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:1905091]; pyruvate metabolic process [GO:0006090]; regulation of autophagy of mitochondrion [GO:1903146]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:7539795}; Multi-pass membrane protein {ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:18832158, ECO:0000269|PubMed:27641616}. Cell membrane {ECO:0000269|PubMed:25168729, ECO:0000269|PubMed:25296756}; Multi-pass membrane protein {ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:18832158}. Membrane raft {ECO:0000269|PubMed:25168729}; Multi-pass membrane protein {ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:18832158}.
P21802	reviewed	FGFR2_HUMAN	Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)	FGFR2 BEK KGFR KSAM	Homo sapiens (Human)	821	FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.		angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; bone development [GO:0060348]; bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; branch elongation involved in salivary gland morphogenesis [GO:0060667]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; branching involved in prostate gland morphogenesis [GO:0060442]; branching involved in salivary gland morphogenesis [GO:0060445]; branching morphogenesis of a nerve [GO:0048755]; bud elongation involved in lung branching [GO:0060449]; cell fate commitment [GO:0045165]; cell-cell signaling [GO:0007267]; cellular response to hypoxia [GO:0071456]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; digestive tract development [GO:0048565]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic organ development [GO:0048568]; embryonic organ morphogenesis [GO:0048562]; embryonic pattern specification [GO:0009880]; endochondral bone growth [GO:0003416]; epidermis morphogenesis [GO:0048730]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; epithelial to mesenchymal transition [GO:0001837]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast growth factor receptor signaling pathway involved in hemopoiesis [GO:0035603]; fibroblast growth factor receptor signaling pathway involved in mammary gland specification [GO:0060595]; fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell [GO:0035602]; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [GO:0035607]; fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow [GO:0035604]; gland morphogenesis [GO:0022612]; hair follicle morphogenesis [GO:0031069]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; lacrimal gland development [GO:0032808]; lateral sprouting from an epithelium [GO:0060601]; limb bud formation [GO:0060174]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung lobe morphogenesis [GO:0060463]; lung-associated mesenchyme development [GO:0060484]; mammary gland bud formation [GO:0060615]; membranous septum morphogenesis [GO:0003149]; mesenchymal cell differentiation [GO:0048762]; mesenchymal cell differentiation involved in lung development [GO:0060915]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesodermal cell differentiation [GO:0048333]; midbrain development [GO:0030901]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; orbitofrontal cortex development [GO:0021769]; organ growth [GO:0035265]; otic vesicle formation [GO:0030916]; outflow tract septum morphogenesis [GO:0003148]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of Wnt signaling pathway [GO:0030177]; post-embryonic development [GO:0009791]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; prostate epithelial cord elongation [GO:0060523]; prostate gland morphogenesis [GO:0060512]; protein autophosphorylation [GO:0046777]; pyramidal neuron development [GO:0021860]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of morphogenesis of a branching structure [GO:0060688]; regulation of osteoblast differentiation [GO:0045667]; regulation of osteoblast proliferation [GO:0033688]; regulation of smooth muscle cell differentiation [GO:0051150]; regulation of smoothened signaling pathway [GO:0008589]; reproductive structure development [GO:0048608]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; skeletal system morphogenesis [GO:0048705]; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; ureteric bud development [GO:0001657]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular zone neuroblast division [GO:0021847]	cell cortex [GO:0005938]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; excitatory synapse [GO:0060076]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]	cell cortex [GO:0005938]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; excitatory synapse [GO:0060076]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; bone development [GO:0060348]; bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; branch elongation involved in salivary gland morphogenesis [GO:0060667]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; branching involved in prostate gland morphogenesis [GO:0060442]; branching involved in salivary gland morphogenesis [GO:0060445]; branching morphogenesis of a nerve [GO:0048755]; bud elongation involved in lung branching [GO:0060449]; cell fate commitment [GO:0045165]; cell-cell signaling [GO:0007267]; cellular response to hypoxia [GO:0071456]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; digestive tract development [GO:0048565]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic organ development [GO:0048568]; embryonic organ morphogenesis [GO:0048562]; embryonic pattern specification [GO:0009880]; endochondral bone growth [GO:0003416]; epidermis morphogenesis [GO:0048730]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; epithelial to mesenchymal transition [GO:0001837]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast growth factor receptor signaling pathway involved in hemopoiesis [GO:0035603]; fibroblast growth factor receptor signaling pathway involved in mammary gland specification [GO:0060595]; fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell [GO:0035602]; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [GO:0035607]; fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow [GO:0035604]; gland morphogenesis [GO:0022612]; hair follicle morphogenesis [GO:0031069]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; lacrimal gland development [GO:0032808]; lateral sprouting from an epithelium [GO:0060601]; limb bud formation [GO:0060174]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung lobe morphogenesis [GO:0060463]; lung-associated mesenchyme development [GO:0060484]; mammary gland bud formation [GO:0060615]; membranous septum morphogenesis [GO:0003149]; mesenchymal cell differentiation [GO:0048762]; mesenchymal cell differentiation involved in lung development [GO:0060915]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesodermal cell differentiation [GO:0048333]; midbrain development [GO:0030901]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; orbitofrontal cortex development [GO:0021769]; organ growth [GO:0035265]; otic vesicle formation [GO:0030916]; outflow tract septum morphogenesis [GO:0003148]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of Wnt signaling pathway [GO:0030177]; post-embryonic development [GO:0009791]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; prostate epithelial cord elongation [GO:0060523]; prostate gland morphogenesis [GO:0060512]; protein autophosphorylation [GO:0046777]; pyramidal neuron development [GO:0021860]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of morphogenesis of a branching structure [GO:0060688]; regulation of osteoblast differentiation [GO:0045667]; regulation of osteoblast proliferation [GO:0033688]; regulation of smooth muscle cell differentiation [GO:0051150]; regulation of smoothened signaling pathway [GO:0008589]; reproductive structure development [GO:0048608]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; skeletal system morphogenesis [GO:0048705]; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; ureteric bud development [GO:0001657]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular zone neuroblast division [GO:0021847]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted.; SUBCELLULAR LOCATION: [Isoform 13]: Secreted.
P21810	reviewed	PGS1_HUMAN	Biglycan (Bone/cartilage proteoglycan I) (PG-S1)	BGN SLRR1A	Homo sapiens (Human)	368	FUNCTION: May be involved in collagen fiber assembly. {ECO:0000250}.		articular cartilage development [GO:0061975]; bone development [GO:0060348]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; sarcolemma [GO:0042383]; transport vesicle [GO:0030133]	cytokine binding [GO:0019955]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; glycosaminoglycan binding [GO:0005539]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; sarcolemma [GO:0042383]; transport vesicle [GO:0030133]; cytokine binding [GO:0019955]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; glycosaminoglycan binding [GO:0005539]; articular cartilage development [GO:0061975]; bone development [GO:0060348]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
P21815	reviewed	SIAL_HUMAN	Bone sialoprotein 2 (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) (Integrin-binding sialoprotein)	IBSP BNSP	Homo sapiens (Human)	317	FUNCTION: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.	MISCELLANEOUS: It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.	bone mineralization [GO:0030282]; cell adhesion [GO:0007155]; cellular response to growth factor stimulus [GO:0071363]; extracellular matrix organization [GO:0030198]; osteoblast differentiation [GO:0001649]; positive regulation of cell adhesion [GO:0045785]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; vesicle [GO:0031982]	integrin binding [GO:0005178]; small molecule binding [GO:0036094]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; vesicle [GO:0031982]; integrin binding [GO:0005178]; small molecule binding [GO:0036094]; bone mineralization [GO:0030282]; cell adhesion [GO:0007155]; cellular response to growth factor stimulus [GO:0071363]; extracellular matrix organization [GO:0030198]; osteoblast differentiation [GO:0001649]; positive regulation of cell adhesion [GO:0045785]	SUBCELLULAR LOCATION: Secreted.
P21817	reviewed	RYR1_HUMAN	Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)	RYR1 RYDR	Homo sapiens (Human)	5038	FUNCTION: Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:18650434, PubMed:18268335, PubMed:11741831, PubMed:16163667, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0, ECO:0000269|PubMed:18268335, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:26115329, ECO:0000305|PubMed:11741831, ECO:0000305|PubMed:16163667}.	MISCELLANEOUS: Coexpression of normal and mutant Thr-4898 RYR1 in a 1:1 ratio produces RYR1 channels with normal halothane and caffeine sensitivities, but maximal levels of Ca(2+) release are reduced by 67%. Binding of [3H]ryanodine indicates that the heterozygous channel is activated by Ca(2+) concentrations 4-fold lower than normal. Single-cell analysis of cotransfected cells shows a significantly increased resting cytoplasmic Ca(2+) level and a significantly reduced luminal Ca(2+) level. These data indicated a leaky channel, possibly caused by a reduction in the Ca(2+) concentration required for channel activation. Comparison with 2 other coexpressed mutant/normal channels suggests that the Thr-4898 mutation produces one of the most abnormal RYR1 channels that has been investigated, and this level of abnormality is reflected in the severe and penetrant phenotype of affected CCD individuals. {ECO:0000269|PubMed:10097181}.	calcium ion transport [GO:0006816]; cellular response to caffeine [GO:0071313]; cellular response to calcium ion [GO:0071277]; muscle contraction [GO:0006936]; ossification involved in bone maturation [GO:0043931]; outflow tract morphogenesis [GO:0003151]; protein homotetramerization [GO:0051289]; regulation of cytosolic calcium ion concentration [GO:0051480]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to caffeine [GO:0031000]; response to hypoxia [GO:0001666]; skeletal muscle fiber development [GO:0048741]; skin development [GO:0043588]; striated muscle contraction [GO:0006941]	calcium channel complex [GO:0034704]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; I band [GO:0031674]; junctional sarcoplasmic reticulum membrane [GO:0014701]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; ryanodine receptor complex [GO:1990425]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; terminal cisterna [GO:0014802]; Z disc [GO:0030018]	ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calcium-release channel activity [GO:0015278]; calmodulin binding [GO:0005516]; ryanodine-sensitive calcium-release channel activity [GO:0005219]; voltage-gated calcium channel activity [GO:0005245]	calcium channel complex [GO:0034704]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; I band [GO:0031674]; junctional sarcoplasmic reticulum membrane [GO:0014701]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; ryanodine receptor complex [GO:1990425]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; terminal cisterna [GO:0014802]; Z disc [GO:0030018]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calcium-release channel activity [GO:0015278]; calmodulin binding [GO:0005516]; ryanodine-sensitive calcium-release channel activity [GO:0005219]; voltage-gated calcium channel activity [GO:0005245]; calcium ion transport [GO:0006816]; cellular response to caffeine [GO:0071313]; cellular response to calcium ion [GO:0071277]; muscle contraction [GO:0006936]; ossification involved in bone maturation [GO:0043931]; outflow tract morphogenesis [GO:0003151]; protein homotetramerization [GO:0051289]; regulation of cytosolic calcium ion concentration [GO:0051480]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to caffeine [GO:0031000]; response to hypoxia [GO:0001666]; skeletal muscle fiber development [GO:0048741]; skin development [GO:0043588]; striated muscle contraction [GO:0006941]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:7556644}; Multi-pass membrane protein {ECO:0000255}. Note=The number of predicted transmembrane domains varies between orthologs. Both N-terminus and C-terminus are cytoplasmic. {ECO:0000250|UniProtKB:P11716}.
P21854	reviewed	CD72_HUMAN	B-cell differentiation antigen CD72 (Lyb-2) (CD antigen CD72)	CD72	Homo sapiens (Human)	359	FUNCTION: Plays a role in B-cell proliferation and differentiation.		cell adhesion [GO:0007155]	plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
P21860	reviewed	ERBB3_HUMAN	Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)	ERBB3 HER3	Homo sapiens (Human)	1342	FUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}.		cranial nerve development [GO:0021545]; endocardial cushion development [GO:0003197]; ERBB2-ERBB3 signaling pathway [GO:0038133]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heart development [GO:0007507]; motor neuron apoptotic process [GO:0097049]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of secretion [GO:0051048]; negative regulation of signal transduction [GO:0009968]; neurogenesis [GO:0022008]; neuron apoptotic process [GO:0051402]; peripheral nervous system development [GO:0007422]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cardiac muscle tissue development [GO:0055025]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein tyrosine kinase activity [GO:0061098]; regulation of cell population proliferation [GO:0042127]; Schwann cell differentiation [GO:0014037]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; wound healing [GO:0042060]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; ERBB3:ERBB2 complex [GO:0038143]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; ErbB-3 class receptor binding [GO:0043125]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; neuregulin binding [GO:0038132]; neuregulin receptor activity [GO:0038131]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein tyrosine kinase activator activity [GO:0030296]; transmembrane signaling receptor activity [GO:0004888]; ubiquitin protein ligase binding [GO:0031625]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; ERBB3:ERBB2 complex [GO:0038143]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; ErbB-3 class receptor binding [GO:0043125]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; neuregulin binding [GO:0038132]; neuregulin receptor activity [GO:0038131]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein tyrosine kinase activator activity [GO:0030296]; transmembrane signaling receptor activity [GO:0004888]; ubiquitin protein ligase binding [GO:0031625]; cranial nerve development [GO:0021545]; endocardial cushion development [GO:0003197]; ERBB2-ERBB3 signaling pathway [GO:0038133]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heart development [GO:0007507]; motor neuron apoptotic process [GO:0097049]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of secretion [GO:0051048]; negative regulation of signal transduction [GO:0009968]; neurogenesis [GO:0022008]; neuron apoptotic process [GO:0051402]; peripheral nervous system development [GO:0007422]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cardiac muscle tissue development [GO:0055025]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein tyrosine kinase activity [GO:0061098]; regulation of cell population proliferation [GO:0042127]; Schwann cell differentiation [GO:0014037]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:33497358}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
P21912	reviewed	SDHB_HUMAN	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip)	SDHB SDH SDH1	Homo sapiens (Human)	280	FUNCTION: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). {ECO:0000269|PubMed:26925370, ECO:0000269|PubMed:27604842}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory electron transport chain [GO:0022904]; tricarboxylic acid cycle [GO:0006099]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [GO:0005749]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	2 iron, 2 sulfur cluster binding [GO:0051537]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; fumarate reductase (menaquinone) [GO:0102040]; metal ion binding [GO:0046872]; succinate dehydrogenase (ubiquinone) activity [GO:0008177]; ubiquinone binding [GO:0048039]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [GO:0005749]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; 2 iron, 2 sulfur cluster binding [GO:0051537]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; fumarate reductase (menaquinone) [GO:0102040]; metal ion binding [GO:0046872]; succinate dehydrogenase (ubiquinone) activity [GO:0008177]; ubiquinone binding [GO:0048039]; aerobic respiration [GO:0009060]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory electron transport chain [GO:0022904]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
P21917	reviewed	DRD4_HUMAN	D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor)	DRD4	Homo sapiens (Human)	419	FUNCTION: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). {ECO:0000250|UniProtKB:P51436, ECO:0000269|PubMed:16423344, ECO:0000269|PubMed:1840645, ECO:0000269|PubMed:27659709, ECO:0000269|PubMed:29051383, ECO:0000269|PubMed:7512953, ECO:0000269|PubMed:7643093, ECO:0000269|PubMed:8078498, ECO:0000269|PubMed:9003072}.		adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; adult locomotory behavior [GO:0008344]; arachidonic acid secretion [GO:0050482]; behavioral fear response [GO:0001662]; behavioral response to cocaine [GO:0048148]; behavioral response to ethanol [GO:0048149]; chemical synaptic transmission [GO:0007268]; dopamine metabolic process [GO:0042417]; dopamine receptor signaling pathway [GO:0007212]; fear response [GO:0042596]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inhibitory postsynaptic potential [GO:0060080]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of protein secretion [GO:0050709]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; positive regulation of dopamine uptake involved in synaptic transmission [GO:0051586]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of sodium:proton antiporter activity [GO:0032417]; regulation of circadian rhythm [GO:0042752]; regulation of dopamine metabolic process [GO:0042053]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; response to amphetamine [GO:0001975]; response to histamine [GO:0034776]; rhythmic process [GO:0048511]; social behavior [GO:0035176]	centrosome [GO:0005813]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity [GO:0004952]; dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; epinephrine binding [GO:0051379]; G protein-coupled serotonin receptor activity [GO:0004993]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; neurotransmitter receptor activity [GO:0030594]; norepinephrine binding [GO:0051380]; potassium channel regulator activity [GO:0015459]; serotonin binding [GO:0051378]; SH3 domain binding [GO:0017124]	centrosome [GO:0005813]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity [GO:0004952]; dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; epinephrine binding [GO:0051379]; G protein-coupled serotonin receptor activity [GO:0004993]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; neurotransmitter receptor activity [GO:0030594]; norepinephrine binding [GO:0051380]; potassium channel regulator activity [GO:0015459]; serotonin binding [GO:0051378]; SH3 domain binding [GO:0017124]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; adult locomotory behavior [GO:0008344]; arachidonic acid secretion [GO:0050482]; behavioral fear response [GO:0001662]; behavioral response to cocaine [GO:0048148]; behavioral response to ethanol [GO:0048149]; chemical synaptic transmission [GO:0007268]; dopamine metabolic process [GO:0042417]; dopamine receptor signaling pathway [GO:0007212]; fear response [GO:0042596]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inhibitory postsynaptic potential [GO:0060080]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of protein secretion [GO:0050709]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; positive regulation of dopamine uptake involved in synaptic transmission [GO:0051586]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of sodium:proton antiporter activity [GO:0032417]; regulation of circadian rhythm [GO:0042752]; regulation of dopamine metabolic process [GO:0042053]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; response to amphetamine [GO:0001975]; response to histamine [GO:0034776]; rhythmic process [GO:0048511]; social behavior [GO:0035176]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1319557, ECO:0000269|PubMed:16423344, ECO:0000269|PubMed:1840645, ECO:0000269|PubMed:20100572, ECO:0000269|PubMed:27659709, ECO:0000269|PubMed:29051383, ECO:0000269|PubMed:7512953, ECO:0000269|PubMed:7643093, ECO:0000269|PubMed:8078498, ECO:0000269|PubMed:9003072}; Multi-pass membrane protein {ECO:0000269|PubMed:20100572, ECO:0000269|PubMed:29051383}.
P21918	reviewed	DRD5_HUMAN	D(1B) dopamine receptor (D(5) dopamine receptor) (D1beta dopamine receptor) (Dopamine D5 receptor)	DRD5 DRD1B DRD1L2	Homo sapiens (Human)	477	FUNCTION: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. {ECO:0000269|PubMed:1834671}.		activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; associative learning [GO:0008306]; cellular response to catecholamine stimulus [GO:0071870]; chemical synaptic transmission [GO:0007268]; dopamine receptor signaling pathway [GO:0007212]; intracellular calcium ion homeostasis [GO:0006874]; long-term synaptic depression [GO:0060292]; negative regulation of blood pressure [GO:0045776]; negative regulation of NAD(P)H oxidase activity [GO:0033861]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; positive regulation of adenylate cyclase activity [GO:0045762]; reactive oxygen species metabolic process [GO:0072593]; regulation of female receptivity [GO:0045924]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; response to amphetamine [GO:0001975]; response to cocaine [GO:0042220]; sensitization [GO:0046960]; synaptic transmission, dopaminergic [GO:0001963]; transmission of nerve impulse [GO:0019226]; wound healing [GO:0042060]	brush border membrane [GO:0031526]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; synapse [GO:0045202]	dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity [GO:0004952]; dopamine neurotransmitter receptor activity, coupled via Gs [GO:0001588]; G protein-coupled receptor activity [GO:0004930]	brush border membrane [GO:0031526]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; synapse [GO:0045202]; dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity [GO:0004952]; dopamine neurotransmitter receptor activity, coupled via Gs [GO:0001588]; G protein-coupled receptor activity [GO:0004930]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; associative learning [GO:0008306]; cellular response to catecholamine stimulus [GO:0071870]; chemical synaptic transmission [GO:0007268]; dopamine receptor signaling pathway [GO:0007212]; intracellular calcium ion homeostasis [GO:0006874]; long-term synaptic depression [GO:0060292]; negative regulation of blood pressure [GO:0045776]; negative regulation of NAD(P)H oxidase activity [GO:0033861]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; positive regulation of adenylate cyclase activity [GO:0045762]; reactive oxygen species metabolic process [GO:0072593]; regulation of female receptivity [GO:0045924]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; response to amphetamine [GO:0001975]; response to cocaine [GO:0042220]; sensitization [GO:0046960]; synaptic transmission, dopaminergic [GO:0001963]; transmission of nerve impulse [GO:0019226]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P21926	reviewed	CD9_HUMAN	CD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9)	CD9 MIC3 TSPAN29 GIG2	Homo sapiens (Human)	228	FUNCTION: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:8478605, PubMed:14575715, PubMed:18541721). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (PubMed:18541721). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (PubMed:8478605, PubMed:7511626). {ECO:0000250|UniProtKB:P40240, ECO:0000269|PubMed:12796480, ECO:0000269|PubMed:14575715, ECO:0000269|PubMed:18541721, ECO:0000269|PubMed:7511626, ECO:0000269|PubMed:8478605}.		cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; glial cell migration [GO:0008347]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of platelet aggregation [GO:0090331]; paranodal junction assembly [GO:0030913]; platelet activation [GO:0030168]; receptor internalization [GO:0031623]; regulation of macrophage migration [GO:1905521]; sperm-egg recognition [GO:0035036]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; protein-containing complex [GO:0032991]	integrin binding [GO:0005178]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; protein-containing complex [GO:0032991]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; glial cell migration [GO:0008347]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of platelet aggregation [GO:0090331]; paranodal junction assembly [GO:0030913]; platelet activation [GO:0030168]; receptor internalization [GO:0031623]; regulation of macrophage migration [GO:1905521]; sperm-egg recognition [GO:0035036]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19640571}; Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Membrane {ECO:0000269|PubMed:19640571}; Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P40240}. Note=Present at the cell surface of oocytes. Accumulates in the adhesion area between the sperm and egg following interaction between IZUMO1 and its receptor IZUMO1R/JUNO. {ECO:0000250|UniProtKB:P40240}.
P21941	reviewed	MATN1_HUMAN	Cartilage matrix protein (Matrilin-1)	MATN1 CMP CRTM	Homo sapiens (Human)	496	FUNCTION: Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.		extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; protein-containing complex assembly [GO:0065003]; regulation of bone mineralization [GO:0030500]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; protein-containing complex assembly [GO:0065003]; regulation of bone mineralization [GO:0030500]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
P21953	reviewed	ODBB_HUMAN	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta)	BCKDHB	Homo sapiens (Human)	392	FUNCTION: Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. {ECO:0000269|PubMed:10745006, ECO:0000269|PubMed:9582350}.		branched-chain amino acid catabolic process [GO:0009083]; lipid metabolic process [GO:0006629]; response to cAMP [GO:0051591]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584]	mitochondrial alpha-ketoglutarate dehydrogenase complex [GO:0005947]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity [GO:0003863]; protein-containing complex binding [GO:0044877]	mitochondrial alpha-ketoglutarate dehydrogenase complex [GO:0005947]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity [GO:0003863]; protein-containing complex binding [GO:0044877]; branched-chain amino acid catabolic process [GO:0009083]; lipid metabolic process [GO:0006629]; response to cAMP [GO:0051591]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000303|PubMed:10745006}.
P21964	reviewed	COMT_HUMAN	Catechol O-methyltransferase (EC 2.1.1.6)	COMT	Homo sapiens (Human)	271	FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. {ECO:0000269|PubMed:11559542, ECO:0000269|PubMed:21846718}.		catecholamine catabolic process [GO:0042424]; cellular response to phosphate starvation [GO:0016036]; developmental process [GO:0032502]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; lipid metabolic process [GO:0006629]; methylation [GO:0032259]; neurotransmitter catabolic process [GO:0042135]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]	catechol O-methyltransferase activity [GO:0016206]; L-dopa O-methyltransferase activity [GO:0102084]; magnesium ion binding [GO:0000287]; methyltransferase activity [GO:0008168]; O-methyltransferase activity [GO:0008171]; orcinol O-methyltransferase activity [GO:0102938]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; catechol O-methyltransferase activity [GO:0016206]; L-dopa O-methyltransferase activity [GO:0102084]; magnesium ion binding [GO:0000287]; methyltransferase activity [GO:0008168]; O-methyltransferase activity [GO:0008171]; orcinol O-methyltransferase activity [GO:0102938]; catecholamine catabolic process [GO:0042424]; cellular response to phosphate starvation [GO:0016036]; developmental process [GO:0032502]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; lipid metabolic process [GO:0006629]; methylation [GO:0032259]; neurotransmitter catabolic process [GO:0042135]	SUBCELLULAR LOCATION: [Isoform Soluble]: Cytoplasm {ECO:0000269|PubMed:11559542}.; SUBCELLULAR LOCATION: [Isoform Membrane-bound]: Cell membrane {ECO:0000269|PubMed:21846718}; Single-pass type II membrane protein {ECO:0000269|PubMed:21846718}; Extracellular side {ECO:0000269|PubMed:21846718}.
P21980	reviewed	TGM2_HUMAN	Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2)	TGM2	Homo sapiens (Human)	687	FUNCTION: Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:9252372, PubMed:23941696, PubMed:31991788). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:7935379, PubMed:9252372, PubMed:27270573). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:7649299, PubMed:7592956, PubMed:18092889). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:9623982, PubMed:20547769). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {ECO:0000250|UniProtKB:P08587, ECO:0000250|UniProtKB:P21981, ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874, ECO:0000269|PubMed:18092889, ECO:0000269|PubMed:20547769, ECO:0000269|PubMed:23797785, ECO:0000269|PubMed:23941696, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:26250429, ECO:0000269|PubMed:27131890, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:30458214, ECO:0000269|PubMed:30867594, ECO:0000269|PubMed:31991788, ECO:0000269|PubMed:32273471, ECO:0000269|PubMed:7592956, ECO:0000269|PubMed:7649299, ECO:0000269|PubMed:7935379, ECO:0000269|PubMed:8943303, ECO:0000269|PubMed:9252372, ECO:0000269|PubMed:9623982, ECO:0000303|PubMed:27270573}.; FUNCTION: [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {ECO:0000269|PubMed:17116873}.		apoptotic cell clearance [GO:0043277]; bone development [GO:0060348]; branching involved in salivary gland morphogenesis [GO:0060445]; cellular response to cocaine [GO:0071314]; cellular response to dopamine [GO:1903351]; cellular response to serotonin [GO:1904015]; dopamine secretion [GO:0014046]; gene expression [GO:0010467]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; peptide cross-linking [GO:0018149]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of neurogenesis [GO:0050769]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; protein deamination [GO:0018277]; protein homooligomerization [GO:0051260]; proteolysis [GO:0006508]; regulation of apoptotic cell clearance [GO:2000425]; regulation of apoptotic process [GO:0042981]; salivary gland cavitation [GO:0060662]	chromatin [GO:0000785]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; histone dopaminyltransferase activity [GO:0120297]; histone serotonyltransferase activity [GO:0120295]; peptidase activity [GO:0008233]; peptide histaminyltransferase activity [GO:0120299]; peptide noradrenalinyltransferase activity [GO:0120298]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; protein-glutamine glutaminase activity [GO:0050568]	chromatin [GO:0000785]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; histone dopaminyltransferase activity [GO:0120297]; histone serotonyltransferase activity [GO:0120295]; peptidase activity [GO:0008233]; peptide histaminyltransferase activity [GO:0120299]; peptide noradrenalinyltransferase activity [GO:0120298]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; protein-glutamine glutaminase activity [GO:0050568]; apoptotic cell clearance [GO:0043277]; bone development [GO:0060348]; branching involved in salivary gland morphogenesis [GO:0060445]; cellular response to cocaine [GO:0071314]; cellular response to dopamine [GO:1903351]; cellular response to serotonin [GO:1904015]; dopamine secretion [GO:0014046]; gene expression [GO:0010467]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; peptide cross-linking [GO:0018149]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of neurogenesis [GO:0050769]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; protein deamination [GO:0018277]; protein homooligomerization [GO:0051260]; proteolysis [GO:0006508]; regulation of apoptotic cell clearance [GO:2000425]; regulation of apoptotic process [GO:0042981]; salivary gland cavitation [GO:0060662]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:9575137}. Nucleus {ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:9575137}. Chromosome {ECO:0000269|PubMed:9575137}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874}. Cell membrane {ECO:0000250|UniProtKB:Q9WVJ6}. Mitochondrion {ECO:0000269|PubMed:24349085}. Note=Mainly localizes to the cytosol (PubMed:9575137). Present at much lower level in the nucleus and chromatin (PubMed:9575137). Also secreted via a non-classical secretion pathway to the extracellular matrix (PubMed:27270573). {ECO:0000269|PubMed:9575137, ECO:0000303|PubMed:27270573}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17116873}.
P22001	reviewed	KCNA3_HUMAN	Potassium voltage-gated channel subfamily A member 3 (HGK5) (HLK3) (HPCN3) (Voltage-gated K(+) channel HuKIII) (Voltage-gated potassium channel subunit Kv1.3)	KCNA3 HGK5	Homo sapiens (Human)	575	FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.		corpus callosum development [GO:0022038]; optic nerve development [GO:0021554]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	axon [GO:0030424]; calyx of Held [GO:0044305]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; voltage-gated monoatomic ion channel activity [GO:0005244]	axon [GO:0030424]; calyx of Held [GO:0044305]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; voltage-gated monoatomic ion channel activity [GO:0005244]; corpus callosum development [GO:0022038]; optic nerve development [GO:0021554]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein.
P22003	reviewed	BMP5_HUMAN	Bone morphogenetic protein 5 (BMP-5)	BMP5	Homo sapiens (Human)	454	FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:29321139, PubMed:11580864). Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509). {ECO:0000269|PubMed:11580864, ECO:0000269|PubMed:20402566, ECO:0000269|PubMed:29321139, ECO:0000269|PubMed:30097509}.		allantois development [GO:1905069]; anterior head development [GO:0097065]; BMP signaling pathway [GO:0030509]; cardiac muscle tissue development [GO:0048738]; cardiac septum morphogenesis [GO:0060411]; cartilage development [GO:0051216]; chorio-allantoic fusion [GO:0060710]; ear development [GO:0043583]; endocardial cushion formation [GO:0003272]; heart trabecula morphogenesis [GO:0061384]; hindbrain development [GO:0030902]; male genitalia development [GO:0030539]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of steroid biosynthetic process [GO:0010894]; neural fold elevation formation [GO:0021502]; ossification [GO:0001503]; pattern specification process [GO:0007389]; pericardium morphogenesis [GO:0003344]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal system development [GO:0001501]; type B pancreatic cell development [GO:0003323]	extracellular space [GO:0005615]; vesicle [GO:0031982]	BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]	extracellular space [GO:0005615]; vesicle [GO:0031982]; BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; allantois development [GO:1905069]; anterior head development [GO:0097065]; BMP signaling pathway [GO:0030509]; cardiac muscle tissue development [GO:0048738]; cardiac septum morphogenesis [GO:0060411]; cartilage development [GO:0051216]; chorio-allantoic fusion [GO:0060710]; ear development [GO:0043583]; endocardial cushion formation [GO:0003272]; heart trabecula morphogenesis [GO:0061384]; hindbrain development [GO:0030902]; male genitalia development [GO:0030539]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of steroid biosynthetic process [GO:0010894]; neural fold elevation formation [GO:0021502]; ossification [GO:0001503]; pattern specification process [GO:0007389]; pericardium morphogenesis [GO:0003344]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal system development [GO:0001501]; type B pancreatic cell development [GO:0003323]	SUBCELLULAR LOCATION: Secreted.
P22004	reviewed	BMP6_HUMAN	Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1)	BMP6 VGR	Homo sapiens (Human)	513	FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (PubMed:31019025). Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV (PubMed:26582087). Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3 (PubMed:30097509, PubMed:31800957). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B (PubMed:18070108). In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (PubMed:33021694). {ECO:0000269|PubMed:18070108, ECO:0000269|PubMed:26582087, ECO:0000269|PubMed:30097509, ECO:0000269|PubMed:31019025, ECO:0000269|PubMed:31800957, ECO:0000269|PubMed:33021694}.		BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; cellular response to iron ion [GO:0071281]; cellular response to mechanical stimulus [GO:0071260]; endochondral ossification [GO:0001958]; eye development [GO:0001654]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular iron ion homeostasis [GO:0006879]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein secretion [GO:0050714]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular permeability [GO:0043117]; response to activity [GO:0014823]; response to glucocorticoid [GO:0051384]; response to magnesium ion [GO:0032026]; response to retinoic acid [GO:0032526]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395]; type B pancreatic cell development [GO:0003323]	extracellular space [GO:0005615]; vesicle [GO:0031982]	BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein heterodimerization activity [GO:0046982]	extracellular space [GO:0005615]; vesicle [GO:0031982]; BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein heterodimerization activity [GO:0046982]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; cellular response to iron ion [GO:0071281]; cellular response to mechanical stimulus [GO:0071260]; endochondral ossification [GO:0001958]; eye development [GO:0001654]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular iron ion homeostasis [GO:0006879]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein secretion [GO:0050714]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular permeability [GO:0043117]; response to activity [GO:0014823]; response to glucocorticoid [GO:0051384]; response to magnesium ion [GO:0032026]; response to retinoic acid [GO:0032526]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395]; type B pancreatic cell development [GO:0003323]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26582087}.
P22033	reviewed	MUTA_HUMAN	Methylmalonyl-CoA mutase, mitochondrial (MCM) (EC 5.4.99.2) (Methylmalonyl-CoA isomerase)	MMUT MUT	Homo sapiens (Human)	750	FUNCTION: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. {ECO:0000269|PubMed:1346616, ECO:0000269|PubMed:1978672, ECO:0000269|PubMed:21138732, ECO:0000269|PubMed:24458, ECO:0000269|PubMed:2453061, ECO:0000269|PubMed:25125334, ECO:0000269|PubMed:27167370, ECO:0000269|PubMed:28101778, ECO:0000269|PubMed:28943303, ECO:0000269|PubMed:29056341}.		homocysteine metabolic process [GO:0050667]; positive regulation of GTPase activity [GO:0043547]; post-embryonic development [GO:0009791]; propionate metabolic process, methylmalonyl pathway [GO:0019678]; succinyl-CoA biosynthetic process [GO:1901290]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	cobalamin binding [GO:0031419]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methylmalonyl-CoA mutase activity [GO:0004494]; modified amino acid binding [GO:0072341]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; cobalamin binding [GO:0031419]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methylmalonyl-CoA mutase activity [GO:0004494]; modified amino acid binding [GO:0072341]; protein homodimerization activity [GO:0042803]; homocysteine metabolic process [GO:0050667]; positive regulation of GTPase activity [GO:0043547]; post-embryonic development [GO:0009791]; propionate metabolic process, methylmalonyl pathway [GO:0019678]; succinyl-CoA biosynthetic process [GO:1901290]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:24458}. Mitochondrion {ECO:0000269|PubMed:28943303}. Cytoplasm {ECO:0000269|PubMed:28943303}.
P22059	reviewed	OSBP1_HUMAN	Oxysterol-binding protein 1	OSBP OSBP1	Homo sapiens (Human)	807	FUNCTION: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}.		bile acid biosynthetic process [GO:0006699]; ceramide transport [GO:0035627]; intracellular cholesterol transport [GO:0032367]; phospholipid transport [GO:0015914]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of secretory granule organization [GO:1904411]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; sphingomyelin biosynthetic process [GO:0006686]; sterol transport [GO:0015918]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	oxysterol binding [GO:0008142]; phosphatidylinositol-4-phosphate binding [GO:0070273]; protein domain specific binding [GO:0019904]; sterol binding [GO:0032934]; sterol transfer activity [GO:0120015]; sterol transporter activity [GO:0015248]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; oxysterol binding [GO:0008142]; phosphatidylinositol-4-phosphate binding [GO:0070273]; protein domain specific binding [GO:0019904]; sterol binding [GO:0032934]; sterol transfer activity [GO:0120015]; sterol transporter activity [GO:0015248]; bile acid biosynthetic process [GO:0006699]; ceramide transport [GO:0035627]; intracellular cholesterol transport [GO:0032367]; phospholipid transport [GO:0015914]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of secretory granule organization [GO:1904411]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; sphingomyelin biosynthetic process [GO:0006686]; sterol transport [GO:0015918]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24209621, ECO:0000269|PubMed:29514919}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:24209621}. Golgi apparatus membrane; Peripheral membrane protein {ECO:0000269|PubMed:24209621}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000269|PubMed:24209621}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:29514919}. Note=Predominantly cytosolic. {ECO:0000269|PubMed:24209621}.
P22061	reviewed	PIMT_HUMAN	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase)	PCMT1	Homo sapiens (Human)	227	FUNCTION: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity). {ECO:0000250|UniProtKB:P23506, ECO:0000269|PubMed:3167043, ECO:0000269|PubMed:6469980}.		protein methylation [GO:0006479]; protein repair [GO:0030091]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]	cadherin binding [GO:0045296]; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; cadherin binding [GO:0045296]; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719]; protein methylation [GO:0006479]; protein repair [GO:0030091]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:3167043}.
P22079	reviewed	PERL_HUMAN	Lactoperoxidase (LPO) (EC 1.11.1.7) (Salivary peroxidase) (SPO)	LPO SAPX	Homo sapiens (Human)	712	FUNCTION: Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (By similarity). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism (PubMed:12626341). Shows antibacterial properties against Pseudomonas aeruginosa (PubMed:12626341). The lactoperoxidase-SCN(-)-H2O2 system shows antibacterial properties against Burkholderia cepacia and Haemophilus influenzae in vitro (PubMed:12626341). Present in mammary and salivary gland secretions and may contribute to airway host defense against infection (PubMed:12626341). May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity). {ECO:0000250|UniProtKB:P80025, ECO:0000250|UniProtKB:Q5SW46, ECO:0000269|PubMed:12626341}.	MISCELLANEOUS: Thiocyanate (SCN(-)) and hypothiocyanite (OSCN(-)) are bound in the distal heme cavity. The iodide ion (I(-)) occupies a position which is stabilized by the interactions with heme moiety, His-226, Arg-372 and Glu-375. Hydrogen peroxide is held between the heme iron and His-226. {ECO:0000250|UniProtKB:P80025}.	defense response to bacterium [GO:0042742]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; thiocyanate peroxidase activity [GO:0036393]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; thiocyanate peroxidase activity [GO:0036393]; defense response to bacterium [GO:0042742]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12626341}. Cytoplasm {ECO:0000250|UniProtKB:Q5SW46}.
P22083	reviewed	FUT4_HUMAN	Alpha-(1,3)-fucosyltransferase 4 (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (ELAM-1 ligand fucosyltransferase) (Fucosyltransferase 4) (Fucosyltransferase IV) (Fuc-TIV) (FucT-IV) (Galactoside 3-L-fucosyltransferase)	FUT4 ELFT FCT3A	Homo sapiens (Human)	530	FUNCTION: [Isoform Short]: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins (PubMed:29593094, PubMed:1702034, PubMed:1716630). Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins (PubMed:29593094, PubMed:1716630). Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity). In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (PubMed:1716630, PubMed:11278338). {ECO:0000250|UniProtKB:Q11127, ECO:0000269|PubMed:1702034, ECO:0000269|PubMed:1716630, ECO:0000269|PubMed:29593094}.; FUNCTION: [Isoform Long]: Does not generate Lewis X antigens. {ECO:0000269|PubMed:29593094}.		carbohydrate metabolic process [GO:0005975]; fucosylation [GO:0036065]; glycosphingolipid biosynthetic process [GO:0006688]; inflammatory response [GO:0006954]; L-fucose catabolic process [GO:0042355]; lymphocyte migration into lymph node [GO:0097022]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of neutrophil migration [GO:1902624]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; regulation of leukocyte cell-cell adhesion [GO:1903037]	cell periphery [GO:0071944]; cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]	cell periphery [GO:0071944]; cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]; carbohydrate metabolic process [GO:0005975]; fucosylation [GO:0036065]; glycosphingolipid biosynthetic process [GO:0006688]; inflammatory response [GO:0006954]; L-fucose catabolic process [GO:0042355]; lymphocyte migration into lymph node [GO:0097022]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of neutrophil migration [GO:1902624]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; regulation of leukocyte cell-cell adhesion [GO:1903037]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
P22087	reviewed	FBRL_HUMAN	rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase) (U6 snRNA 2'-O-methyltransferase fibrillarin)	FBL FIB1 FLRN	Homo sapiens (Human)	321	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:24352239, PubMed:30540930, PubMed:32017898). Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:30540930). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239, PubMed:30540930). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P15646, ECO:0000269|PubMed:24352239, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:32017898, ECO:0000269|PubMed:34516797}.		box C/D RNA 3'-end processing [GO:0000494]; osteoblast differentiation [GO:0001649]; ribosomal small subunit biogenesis [GO:0042274]; rRNA methylation [GO:0031167]; rRNA processing [GO:0006364]; snoRNA localization [GO:0048254]	box C/D RNP complex [GO:0031428]; Cajal body [GO:0015030]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; granular component [GO:0001652]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]	ATPase binding [GO:0051117]; histone H2AQ104 methyltransferase activity [GO:1990259]; RNA binding [GO:0003723]; rRNA methyltransferase activity [GO:0008649]; TFIID-class transcription factor complex binding [GO:0001094]	box C/D RNP complex [GO:0031428]; Cajal body [GO:0015030]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; granular component [GO:0001652]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; ATPase binding [GO:0051117]; histone H2AQ104 methyltransferase activity [GO:1990259]; RNA binding [GO:0003723]; rRNA methyltransferase activity [GO:0008649]; TFIID-class transcription factor complex binding [GO:0001094]; box C/D RNA 3'-end processing [GO:0000494]; osteoblast differentiation [GO:0001649]; ribosomal small subunit biogenesis [GO:0042274]; rRNA methylation [GO:0031167]; rRNA processing [GO:0006364]; snoRNA localization [GO:0048254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:14583623, ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:2026646, ECO:0000269|PubMed:2414294, ECO:0000269|PubMed:24352239, ECO:0000269|PubMed:34516797}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P35550}. Note=Fibrillar region of the nucleolus.
P22102	reviewed	PUR2_HUMAN	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]	GART PGFT PRGS	Homo sapiens (Human)	1010	FUNCTION: Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}.		'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; adenine biosynthetic process [GO:0046084]; brainstem development [GO:0003360]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; glycine metabolic process [GO:0006544]; GMP biosynthetic process [GO:0006177]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to inorganic substance [GO:0010035]; response to organic substance [GO:0010033]; tetrahydrofolate biosynthetic process [GO:0046654]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylamine-glycine ligase activity [GO:0004637]; phosphoribosylformylglycinamidine cyclo-ligase activity [GO:0004641]; phosphoribosylglycinamide formyltransferase activity [GO:0004644]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylamine-glycine ligase activity [GO:0004637]; phosphoribosylformylglycinamidine cyclo-ligase activity [GO:0004641]; phosphoribosylglycinamide formyltransferase activity [GO:0004644]; 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; adenine biosynthetic process [GO:0046084]; brainstem development [GO:0003360]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; glycine metabolic process [GO:0006544]; GMP biosynthetic process [GO:0006177]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to inorganic substance [GO:0010035]; response to organic substance [GO:0010033]; tetrahydrofolate biosynthetic process [GO:0046654]	
P22105	reviewed	TENX_HUMAN	Tenascin-X (TN-X) (Hexabrachion-like protein)	TNXB HXBL TNX TNXB1 TNXB2 XB	Homo sapiens (Human)	4244	FUNCTION: Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. {ECO:0000269|PubMed:17033827}.	MISCELLANEOUS: [Isoform 4]: May be due to competing acceptor splice site in exon 24.; MISCELLANEOUS: [Isoform 5]: May be due to competing donor splice site in exon 1. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; fatty acid metabolic process [GO:0006631]; neuron projection development [GO:0031175]; positive regulation of cell fate determination [GO:1905935]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transforming growth factor beta activation [GO:1901390]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of cell migration [GO:0030334]; triglyceride metabolic process [GO:0006641]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; tenascin complex [GO:0090733]	collagen binding [GO:0005518]; collagen fibril binding [GO:0098633]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; integrin binding [GO:0005178]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; tenascin complex [GO:0090733]; collagen binding [GO:0005518]; collagen fibril binding [GO:0098633]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; fatty acid metabolic process [GO:0006631]; neuron projection development [GO:0031175]; positive regulation of cell fate determination [GO:1905935]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transforming growth factor beta activation [GO:1901390]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of cell migration [GO:0030334]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
P22223	reviewed	CADH3_HUMAN	Cadherin-3 (Placental cadherin) (P-cadherin)	CDH3 CDHP	Homo sapiens (Human)	829	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; hair cycle process [GO:0022405]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinization [GO:0031424]; negative regulation of timing of catagen [GO:0051796]; negative regulation of transforming growth factor beta2 production [GO:0032912]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of melanosome transport [GO:1902910]; positive regulation of tyrosinase activity [GO:0032773]; regulation of hair cycle by canonical Wnt signaling pathway [GO:0060901]; response to xenobiotic stimulus [GO:0009410]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; hair cycle process [GO:0022405]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinization [GO:0031424]; negative regulation of timing of catagen [GO:0051796]; negative regulation of transforming growth factor beta2 production [GO:0032912]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of melanosome transport [GO:1902910]; positive regulation of tyrosinase activity [GO:0032773]; regulation of hair cycle by canonical Wnt signaling pathway [GO:0060901]; response to xenobiotic stimulus [GO:0009410]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P22234	reviewed	PUR6_HUMAN	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)]	PAICS ADE2 AIRC PAIS	Homo sapiens (Human)	425	FUNCTION: Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}.		'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	5-amino-4-imidazole carboxylate lyase activity [GO:0043727]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphoribosylaminoimidazole carboxylase activity [GO:0004638]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; 5-amino-4-imidazole carboxylate lyase activity [GO:0043727]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphoribosylaminoimidazole carboxylase activity [GO:0004638]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639]; 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113]	
P22301	reviewed	IL10_HUMAN	Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF)	IL10	Homo sapiens (Human)	178	FUNCTION: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed:1940799, PubMed:7512027, PubMed:11564774). Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity). {ECO:0000250|UniProtKB:P18893, ECO:0000269|PubMed:11564774, ECO:0000269|PubMed:16982608, ECO:0000269|PubMed:18025162, ECO:0000269|PubMed:1940799, ECO:0000269|PubMed:7512027, ECO:0000269|PubMed:8144879}.		B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to lipopolysaccharide [GO:0071222]; chronic inflammatory response to antigenic stimulus [GO:0002439]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; endothelial cell apoptotic process [GO:0072577]; hemopoiesis [GO:0030097]; leukocyte chemotaxis [GO:0030595]; liver regeneration [GO:0097421]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of chronic inflammatory response to antigenic stimulus [GO:0002875]; negative regulation of cytokine activity [GO:0060302]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-18 production [GO:0032701]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of myeloid dendritic cell activation [GO:0030886]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of macrophage activation [GO:0043032]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of gene expression [GO:0010468]; regulation of isotype switching [GO:0045191]; regulation of response to wounding [GO:1903034]; regulation of synapse organization [GO:0050807]; response to activity [GO:0014823]; response to carbon monoxide [GO:0034465]; response to glucocorticoid [GO:0051384]; response to inactivity [GO:0014854]; response to insulin [GO:0032868]; response to molecule of bacterial origin [GO:0002237]; response to xenobiotic stimulus [GO:0009410]; type 2 immune response [GO:0042092]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-10 receptor binding [GO:0005141]; protein dimerization activity [GO:0046983]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-10 receptor binding [GO:0005141]; protein dimerization activity [GO:0046983]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to lipopolysaccharide [GO:0071222]; chronic inflammatory response to antigenic stimulus [GO:0002439]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; endothelial cell apoptotic process [GO:0072577]; hemopoiesis [GO:0030097]; leukocyte chemotaxis [GO:0030595]; liver regeneration [GO:0097421]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of chronic inflammatory response to antigenic stimulus [GO:0002875]; negative regulation of cytokine activity [GO:0060302]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-18 production [GO:0032701]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of myeloid dendritic cell activation [GO:0030886]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of macrophage activation [GO:0043032]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of gene expression [GO:0010468]; regulation of isotype switching [GO:0045191]; regulation of response to wounding [GO:1903034]; regulation of synapse organization [GO:0050807]; response to activity [GO:0014823]; response to carbon monoxide [GO:0034465]; response to glucocorticoid [GO:0051384]; response to inactivity [GO:0014854]; response to insulin [GO:0032868]; response to molecule of bacterial origin [GO:0002237]; response to xenobiotic stimulus [GO:0009410]; type 2 immune response [GO:0042092]	SUBCELLULAR LOCATION: Secreted.
P22303	reviewed	ACES_HUMAN	Acetylcholinesterase (AChE) (EC 3.1.1.7)	ACHE	Homo sapiens (Human)	614	FUNCTION: Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis. {ECO:0000269|PubMed:11985878, ECO:0000269|PubMed:1517212, ECO:0000269|PubMed:1748670, ECO:0000269|PubMed:2714437}.		acetylcholine catabolic process [GO:0006581]; acetylcholine catabolic process in synaptic cleft [GO:0001507]; acetylcholine receptor signaling pathway [GO:0095500]; amyloid precursor protein metabolic process [GO:0042982]; cell adhesion [GO:0007155]; negative regulation of synaptic transmission, cholinergic [GO:0032223]; nervous system development [GO:0007399]; osteoblast development [GO:0002076]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein secretion [GO:0050714]; receptor internalization [GO:0031623]; regulation of receptor recycling [GO:0001919]; retina development in camera-type eye [GO:0060041]; synapse assembly [GO:0007416]	basement membrane [GO:0005604]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	acetylcholine binding [GO:0042166]; acetylcholinesterase activity [GO:0003990]; amyloid-beta binding [GO:0001540]; cholinesterase activity [GO:0004104]; collagen binding [GO:0005518]; hydrolase activity [GO:0016787]; laminin binding [GO:0043236]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]; serine hydrolase activity [GO:0017171]	basement membrane [GO:0005604]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]; synaptic cleft [GO:0043083]; acetylcholine binding [GO:0042166]; acetylcholinesterase activity [GO:0003990]; amyloid-beta binding [GO:0001540]; cholinesterase activity [GO:0004104]; collagen binding [GO:0005518]; hydrolase activity [GO:0016787]; laminin binding [GO:0043236]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]; serine hydrolase activity [GO:0017171]; acetylcholine catabolic process [GO:0006581]; acetylcholine catabolic process in synaptic cleft [GO:0001507]; acetylcholine receptor signaling pathway [GO:0095500]; amyloid precursor protein metabolic process [GO:0042982]; cell adhesion [GO:0007155]; negative regulation of synaptic transmission, cholinergic [GO:0032223]; nervous system development [GO:0007399]; osteoblast development [GO:0002076]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein secretion [GO:0050714]; receptor internalization [GO:0031623]; regulation of receptor recycling [GO:0001919]; retina development in camera-type eye [GO:0060041]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:11985878, ECO:0000269|PubMed:1748670}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform T]: Nucleus. Note=Only observed in apoptotic nuclei.; SUBCELLULAR LOCATION: [Isoform H]: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.
P22304	reviewed	IDS_HUMAN	Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain]	IDS SIDS	Homo sapiens (Human)	550	FUNCTION: Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. {ECO:0000269|PubMed:10838181, ECO:0000269|PubMed:11731225, ECO:0000269|PubMed:28593992}.		dermatan sulfate catabolic process [GO:0030209]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]	cytoplasm [GO:0005737]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	calcium ion binding [GO:0005509]; iduronate-2-sulfatase activity [GO:0004423]	cytoplasm [GO:0005737]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; calcium ion binding [GO:0005509]; iduronate-2-sulfatase activity [GO:0004423]; dermatan sulfate catabolic process [GO:0030209]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:10838181}.
P22307	reviewed	SCP2_HUMAN	Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (SCPX) (Sterol carrier protein X) (SCP-X)	SCP2	Homo sapiens (Human)	547	FUNCTION: [Isoform SCPx]: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:10706581). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:10706581). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity). {ECO:0000250|UniProtKB:P11915, ECO:0000250|UniProtKB:P32020, ECO:0000269|PubMed:10706581}.; FUNCTION: [Isoform SCP2]: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (PubMed:17157249, PubMed:8300590, PubMed:7642518). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity). {ECO:0000250|UniProtKB:P11915, ECO:0000250|UniProtKB:P32020, ECO:0000269|PubMed:17157249, ECO:0000269|PubMed:7642518, ECO:0000269|PubMed:8300590}.	MISCELLANEOUS: [Isoform SCP2]: Contains a putative mitochondrial transit peptide at positions 1-20. {ECO:0000305|PubMed:17157249}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Produced by alternative splicing. {ECO:0000305}.	alpha-linolenic acid metabolic process [GO:0036109]; bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; inositol trisphosphate biosynthetic process [GO:0032959]; intracellular cholesterol transport [GO:0032367]; lipid hydroperoxide transport [GO:1901373]; phospholipid transport [GO:0015914]; positive regulation of intracellular cholesterol transport [GO:0032385]; positive regulation of steroid metabolic process [GO:0045940]; progesterone biosynthetic process [GO:0006701]; protein localization to plasma membrane [GO:0072659]; regulation of phospholipid biosynthetic process [GO:0071071]; steroid biosynthetic process [GO:0006694]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; fatty-acyl-CoA binding [GO:0000062]; long-chain fatty acyl-CoA binding [GO:0036042]; oleic acid binding [GO:0070538]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylinositol transfer activity [GO:0008526]; propanoyl-CoA C-acyltransferase activity [GO:0033814]; propionyl-CoA C2-trimethyltridecanoyltransferase activity [GO:0050632]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; fatty-acyl-CoA binding [GO:0000062]; long-chain fatty acyl-CoA binding [GO:0036042]; oleic acid binding [GO:0070538]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylinositol transfer activity [GO:0008526]; propanoyl-CoA C-acyltransferase activity [GO:0033814]; propionyl-CoA C2-trimethyltridecanoyltransferase activity [GO:0050632]; signaling receptor binding [GO:0005102]; alpha-linolenic acid metabolic process [GO:0036109]; bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; inositol trisphosphate biosynthetic process [GO:0032959]; intracellular cholesterol transport [GO:0032367]; lipid hydroperoxide transport [GO:1901373]; phospholipid transport [GO:0015914]; positive regulation of intracellular cholesterol transport [GO:0032385]; positive regulation of steroid metabolic process [GO:0045940]; progesterone biosynthetic process [GO:0006701]; protein localization to plasma membrane [GO:0072659]; regulation of phospholipid biosynthetic process [GO:0071071]; steroid biosynthetic process [GO:0006694]	SUBCELLULAR LOCATION: [Isoform SCP2]: Peroxisome {ECO:0000250|UniProtKB:P32020}. Cytoplasm {ECO:0000269|PubMed:10706581, ECO:0000269|PubMed:17157249}. Mitochondrion {ECO:0000269|PubMed:17157249}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P32020}. Mitochondrion {ECO:0000250|UniProtKB:P32020}.; SUBCELLULAR LOCATION: [Isoform SCPx]: Peroxisome {ECO:0000250|UniProtKB:P11915}.
P22309	reviewed	UD11_HUMAN	UDP-glucuronosyltransferase 1A1 (UGT1A1) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 1) (hUG-BR1) (UDP-glucuronosyltransferase 1-1) (UDPGT 1-1) (UGT1*1) (UGT1-01) (UGT1.1) (UDP-glucuronosyltransferase 1A isoform 1)	UGT1A1 GNT1 UGT1	Homo sapiens (Human)	533	FUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:18004206, PubMed:18004212, PubMed:18719240, PubMed:19830808, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004206, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:15472229, PubMed:18719240, PubMed:23288867). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (PubMed:17187418, PubMed:18004206, PubMed:19830808). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558). {ECO:0000269|PubMed:12181437, ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:17187418, ECO:0000269|PubMed:18004206, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18052087, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19545173, ECO:0000269|PubMed:19830808, ECO:0000269|PubMed:20610558, ECO:0000269|PubMed:23288867}.; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:17187418, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558}.	MISCELLANEOUS: UGT1A1 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity. {ECO:0000269|PubMed:18004212}.	acute-phase response [GO:0006953]; animal organ regeneration [GO:0031100]; bilirubin conjugation [GO:0006789]; biphenyl catabolic process [GO:0070980]; cellular glucuronidation [GO:0052695]; cellular response to estradiol stimulus [GO:0071392]; cellular response to ethanol [GO:0071361]; cellular response to glucocorticoid stimulus [GO:0071385]; estrogen metabolic process [GO:0008210]; flavone metabolic process [GO:0051552]; flavonoid glucuronidation [GO:0052696]; heterocycle metabolic process [GO:0046483]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; negative regulation of steroid metabolic process [GO:0045939]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; retinoic acid metabolic process [GO:0042573]; steroid metabolic process [GO:0008202]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]	cytochrome complex [GO:0070069]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]; steroid binding [GO:0005496]	cytochrome complex [GO:0070069]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]; steroid binding [GO:0005496]; acute-phase response [GO:0006953]; animal organ regeneration [GO:0031100]; bilirubin conjugation [GO:0006789]; biphenyl catabolic process [GO:0070980]; cellular glucuronidation [GO:0052695]; cellular response to estradiol stimulus [GO:0071392]; cellular response to ethanol [GO:0071361]; cellular response to glucocorticoid stimulus [GO:0071385]; estrogen metabolic process [GO:0008210]; flavone metabolic process [GO:0051552]; flavonoid glucuronidation [GO:0052696]; heterocycle metabolic process [GO:0046483]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; negative regulation of steroid metabolic process [GO:0045939]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; retinoic acid metabolic process [GO:0042573]; steroid metabolic process [GO:0008202]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17179145, ECO:0000269|PubMed:17187418}; Single-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17187418}.
P22310	reviewed	UD14_HUMAN	UDP-glucuronosyltransferase 1A4 (UGT1A4) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 2) (hUG-BR2) (UDP-glucuronosyltransferase 1-4) (UDPGT 1-4) (UGT1*4) (UGT1-04) (UGT1.4) (UDP-glucuronosyltransferase 1-D) (UGT-1D) (UGT1D)	UGT1A4 GNT1 UGT1	Homo sapiens (Human)	534	FUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18177842, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18177842). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption (PubMed:18177842). {ECO:0000269|PubMed:18177842, ECO:0000269|PubMed:24641623}.; FUNCTION: [Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558}.	MISCELLANEOUS: UGT1A4 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity. {ECO:0000269|PubMed:18004212}.	bilirubin conjugation [GO:0006789]; cellular glucuronidation [GO:0052695]; heme catabolic process [GO:0042167]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; vitamin D3 metabolic process [GO:0070640]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; bilirubin conjugation [GO:0006789]; cellular glucuronidation [GO:0052695]; heme catabolic process [GO:0042167]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; vitamin D3 metabolic process [GO:0070640]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17179145}; Single-pass membrane protein {ECO:0000255}.
P22314	reviewed	UBA1_HUMAN	Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)	UBA1 A1S9T UBE1	Homo sapiens (Human)	1058	FUNCTION: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}.	MISCELLANEOUS: There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. {ECO:0000250|UniProtKB:P22515}.	DNA damage response [GO:0006974]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin activating enzyme activity [GO:0004839]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin activating enzyme activity [GO:0004839]; DNA damage response [GO:0006974]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1376922}. Mitochondrion {ECO:0000269|PubMed:1376922}. Nucleus {ECO:0000269|PubMed:1376922, ECO:0000269|PubMed:22456334}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:33108101, ECO:0000269|PubMed:7528747, ECO:0000269|PubMed:9099746}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:33108101, ECO:0000269|PubMed:7528747}.
P22352	reviewed	GPX3_HUMAN	Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P)	GPX3 GPXP	Homo sapiens (Human)	226	FUNCTION: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. {ECO:0000269|PubMed:1897960}.		hydrogen peroxide catabolic process [GO:0042744]; response to lipid hydroperoxide [GO:0006982]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	glutathione peroxidase activity [GO:0004602]; identical protein binding [GO:0042802]; selenium binding [GO:0008430]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutathione peroxidase activity [GO:0004602]; identical protein binding [GO:0042802]; selenium binding [GO:0008430]; hydrogen peroxide catabolic process [GO:0042744]; response to lipid hydroperoxide [GO:0006982]	SUBCELLULAR LOCATION: Secreted.
P22362	reviewed	CCL1_HUMAN	C-C motif chemokine 1 (Small-inducible cytokine A1) (T lymphocyte-secreted protein I-309)	CCL1 SCYA1	Homo sapiens (Human)	96	FUNCTION: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. {ECO:0000269|PubMed:1557400}.		cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of monocyte chemotaxis [GO:0090026]; signal transduction [GO:0007165]; viral process [GO:0016032]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of monocyte chemotaxis [GO:0090026]; signal transduction [GO:0007165]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Secreted.
P22392	reviewed	NDKB_HUMAN	Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2)	NME2 NM23B	Homo sapiens (Human)	152	FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752, PubMed:19435876). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}.	MISCELLANEOUS: [Isoform 3]: Based on a naturally occurring readthrough transcript which produces an NME1-NME2 fusion protein. {ECO:0000269|PubMed:16442775}.	cell adhesion [GO:0007155]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of apoptotic process [GO:0043066]; nucleoside triphosphate biosynthetic process [GO:0009142]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of epidermis development [GO:0045682]; UTP biosynthetic process [GO:0006228]	cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; G-quadruplex DNA binding [GO:0051880]; GDP binding [GO:0019003]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]; protein histidine kinase activity [GO:0004673]; transcription coactivator activity [GO:0003713]	cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; G-quadruplex DNA binding [GO:0051880]; GDP binding [GO:0019003]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]; protein histidine kinase activity [GO:0004673]; transcription coactivator activity [GO:0003713]; cell adhesion [GO:0007155]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of apoptotic process [GO:0043066]; nucleoside triphosphate biosynthetic process [GO:0009142]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of epidermis development [GO:0045682]; UTP biosynthetic process [GO:0006228]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17532299}. Cell projection, lamellipodium {ECO:0000269|PubMed:11919189}. Cell projection, ruffle {ECO:0000269|PubMed:11919189}. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {ECO:0000269|PubMed:11919189}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16442775}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16442775}. Nucleus {ECO:0000269|PubMed:16442775}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:16442775}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16442775}. Nucleus {ECO:0000269|PubMed:16442775}.
P22413	reviewed	ENPP1_HUMAN	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Membrane component chromosome 6 surface marker 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]	ENPP1 M6S1 NPPS PC1 PDNP1	Homo sapiens (Human)	925	FUNCTION: Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (By similarity). PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals (PubMed:11004006). Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP (PubMed:27467858, PubMed:8001561, PubMed:25344812, PubMed:28011303, PubMed:35147247). May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling (PubMed:27467858, PubMed:8001561). Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect (By similarity). Appears to modulate insulin sensitivity and function (PubMed:10615944). Also involved in melanogenesis (PubMed:28964717). Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production (PubMed:25344812). 2',3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2',3'-cGAMP hydrolysis is therefore unclear (PubMed:25344812). Not able to hydrolyze the 2',3'-cGAMP linkage isomer 3'-3'-cGAMP (PubMed:25344812). {ECO:0000250|UniProtKB:P06802, ECO:0000269|PubMed:10615944, ECO:0000269|PubMed:25344812, ECO:0000269|PubMed:27467858, ECO:0000269|PubMed:28011303, ECO:0000269|PubMed:28964717, ECO:0000269|PubMed:35147247, ECO:0000269|PubMed:8001561, ECO:0000305|PubMed:11004006}.		3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; ATP metabolic process [GO:0046034]; bone mineralization [GO:0030282]; cellular response to insulin stimulus [GO:0032869]; gene expression [GO:0010467]; generation of precursor metabolites and energy [GO:0006091]; immune response [GO:0006955]; inorganic diphosphate transport [GO:0030505]; intracellular phosphate ion homeostasis [GO:0030643]; melanocyte differentiation [GO:0030318]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell growth [GO:0030308]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of glucose import [GO:0046325]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of hh target transcription factor activity [GO:1990787]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of protein autophosphorylation [GO:0031953]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; nucleoside triphosphate catabolic process [GO:0009143]; phosphate ion homeostasis [GO:0055062]; phosphate-containing compound metabolic process [GO:0006796]; regulation of bone mineralization [GO:0030500]; response to ATP [GO:0033198]; response to inorganic substance [GO:0010035]; sequestering of triglyceride [GO:0030730]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; ATP binding [GO:0005524]; ATP diphosphatase activity [GO:0047693]; calcium ion binding [GO:0005509]; cyclic-GMP-AMP hydrolase activity [GO:0106177]; dinucleotide phosphatase activity [GO:0004551]; exonuclease activity [GO:0004527]; GTP diphosphatase activity [GO:0036219]; insulin receptor binding [GO:0005158]; nucleic acid binding [GO:0003676]; nucleoside triphosphate diphosphatase activity [GO:0047429]; phosphatase activity [GO:0016791]; phosphodiesterase I activity [GO:0004528]; polysaccharide binding [GO:0030247]; protein homodimerization activity [GO:0042803]; scavenger receptor activity [GO:0005044]; UTP diphosphatase activity [GO:0036221]; zinc ion binding [GO:0008270]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; ATP binding [GO:0005524]; ATP diphosphatase activity [GO:0047693]; calcium ion binding [GO:0005509]; cyclic-GMP-AMP hydrolase activity [GO:0106177]; dinucleotide phosphatase activity [GO:0004551]; exonuclease activity [GO:0004527]; GTP diphosphatase activity [GO:0036219]; insulin receptor binding [GO:0005158]; nucleic acid binding [GO:0003676]; nucleoside triphosphate diphosphatase activity [GO:0047429]; phosphatase activity [GO:0016791]; phosphodiesterase I activity [GO:0004528]; polysaccharide binding [GO:0030247]; protein homodimerization activity [GO:0042803]; scavenger receptor activity [GO:0005044]; UTP diphosphatase activity [GO:0036221]; zinc ion binding [GO:0008270]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; ATP metabolic process [GO:0046034]; bone mineralization [GO:0030282]; cellular response to insulin stimulus [GO:0032869]; gene expression [GO:0010467]; generation of precursor metabolites and energy [GO:0006091]; immune response [GO:0006955]; inorganic diphosphate transport [GO:0030505]; intracellular phosphate ion homeostasis [GO:0030643]; melanocyte differentiation [GO:0030318]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell growth [GO:0030308]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of glucose import [GO:0046325]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of hh target transcription factor activity [GO:1990787]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of protein autophosphorylation [GO:0031953]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; nucleoside triphosphate catabolic process [GO:0009143]; phosphate ion homeostasis [GO:0055062]; phosphate-containing compound metabolic process [GO:0006796]; regulation of bone mineralization [GO:0030500]; response to ATP [GO:0033198]; response to inorganic substance [GO:0010035]; sequestering of triglyceride [GO:0030730]	SUBCELLULAR LOCATION: [Ectonucleotide pyrophosphatase/phosphodiesterase family member 1]: Cell membrane {ECO:0000269|PubMed:15072822, ECO:0000269|PubMed:27467858, ECO:0000269|PubMed:8001561}; Single-pass type II membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:11598187}; Single-pass type II membrane protein. Note=Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts (PubMed:11598187). In bile duct cells and cancer cells, located to the apical cytoplasmic side (PubMed:11598187). {ECO:0000269|PubMed:11598187}.; SUBCELLULAR LOCATION: [Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]: Secreted {ECO:0000250|UniProtKB:P06802}. Note=Secreted following proteolytic cleavage. {ECO:0000250|UniProtKB:P06802}.
P22415	reviewed	USF1_HUMAN	Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1)	USF1 BHLHB11 USF	Homo sapiens (Human)	310	FUNCTION: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.		carbon catabolite regulation of transcription [GO:0045990]; cellular response to insulin stimulus [GO:0032869]; glucose homeostasis [GO:0042593]; late viral transcription [GO:0019086]; lipid homeostasis [GO:0055088]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter by glucose [GO:0000430]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]	chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; carbon catabolite regulation of transcription [GO:0045990]; cellular response to insulin stimulus [GO:0032869]; glucose homeostasis [GO:0042593]; late viral transcription [GO:0019086]; lipid homeostasis [GO:0055088]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter by glucose [GO:0000430]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]	SUBCELLULAR LOCATION: Nucleus.
P22455	reviewed	FGFR4_HUMAN	Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)	FGFR4 JTK2 TKF	Homo sapiens (Human)	802	FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. {ECO:0000269|PubMed:11433297, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:18670643, ECO:0000269|PubMed:20018895, ECO:0000269|PubMed:20683963, ECO:0000269|PubMed:20798051, ECO:0000269|PubMed:20876804, ECO:0000269|PubMed:21653700, ECO:0000269|PubMed:7518429, ECO:0000269|PubMed:7680645, ECO:0000269|PubMed:8663044}.		cell migration [GO:0016477]; cholesterol homeostasis [GO:0042632]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glucose homeostasis [GO:0042593]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphate ion homeostasis [GO:0055062]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of proteolysis [GO:0045862]; protein autophosphorylation [GO:0046777]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of lipid metabolic process [GO:0019216]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transport vesicle [GO:0030133]	ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]	endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transport vesicle [GO:0030133]; ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]; cell migration [GO:0016477]; cholesterol homeostasis [GO:0042632]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glucose homeostasis [GO:0042593]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphate ion homeostasis [GO:0055062]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of proteolysis [GO:0045862]; protein autophosphorylation [GO:0046777]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of lipid metabolic process [GO:0019216]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
P22459	reviewed	KCNA4_HUMAN	Potassium voltage-gated channel subfamily A member 4 (HPCN2) (Voltage-gated K(+) channel HuKII) (Voltage-gated potassium channel HBK4) (Voltage-gated potassium channel HK1) (Voltage-gated potassium channel subunit Kv1.4)	KCNA4 KCNA4L	Homo sapiens (Human)	653	FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). {ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:27582084, ECO:0000269|PubMed:8495559}.		potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	axon [GO:0030424]; axon initial segment [GO:0043194]; dendritic spine [GO:0043197]; membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; potassium ion binding [GO:0030955]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]	axon [GO:0030424]; axon initial segment [GO:0043194]; dendritic spine [GO:0043197]; membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; potassium ion binding [GO:0030955]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:19968958, ECO:0000269|PubMed:8495559}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P15385}.
P22460	reviewed	KCNA5_HUMAN	Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5)	KCNA5	Homo sapiens (Human)	613	FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461). {ECO:0000269|PubMed:11524461, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:8505626}.		atrial cardiac muscle cell action potential [GO:0086014]; membrane hyperpolarization [GO:0060081]; membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; membrane repolarization during bundle of His cell action potential [GO:0086050]; membrane repolarization during SA node cell action potential [GO:0086052]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; Notch signaling pathway [GO:0007219]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of myoblast proliferation [GO:2000288]; potassium ion export across plasma membrane [GO:0097623]; potassium ion homeostasis [GO:0055075]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of insulin secretion [GO:0050796]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transport [GO:0043266]; regulation of vasoconstriction [GO:0019229]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]	cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; intracellular canaliculus [GO:0046691]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; voltage-gated potassium channel complex [GO:0008076]; Z disc [GO:0030018]	alpha-actinin binding [GO:0051393]; delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]; voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization [GO:0086087]; voltage-gated potassium channel activity involved in SA node cell action potential repolarization [GO:0086090]	cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; intracellular canaliculus [GO:0046691]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; voltage-gated potassium channel complex [GO:0008076]; Z disc [GO:0030018]; alpha-actinin binding [GO:0051393]; delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]; voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization [GO:0086087]; voltage-gated potassium channel activity involved in SA node cell action potential repolarization [GO:0086090]; atrial cardiac muscle cell action potential [GO:0086014]; membrane hyperpolarization [GO:0060081]; membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; membrane repolarization during bundle of His cell action potential [GO:0086050]; membrane repolarization during SA node cell action potential [GO:0086052]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; Notch signaling pathway [GO:0007219]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of myoblast proliferation [GO:2000288]; potassium ion export across plasma membrane [GO:0097623]; potassium ion homeostasis [GO:0055075]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of insulin secretion [GO:0050796]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transport [GO:0043266]; regulation of vasoconstriction [GO:0019229]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:8505626}; Multi-pass membrane protein {ECO:0000305}.
P22466	reviewed	GALA_HUMAN	Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide (GMAP)]	GAL GAL1 GALN GLNN	Homo sapiens (Human)	123	FUNCTION: Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion. {ECO:0000269|PubMed:1370155, ECO:0000269|PubMed:1722333, ECO:0000269|PubMed:25691535}.		cAMP-mediated signaling [GO:0019933]; feeding behavior [GO:0007631]; insulin secretion [GO:0030073]; negative regulation of lymphocyte proliferation [GO:0050672]; neuropeptide signaling pathway [GO:0007218]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cortisol secretion [GO:0051464]; positive regulation of large conductance calcium-activated potassium channel activity [GO:1902608]; positive regulation of timing of catagen [GO:0051795]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein kinase A signaling [GO:0010737]; regulation of glucocorticoid metabolic process [GO:0031943]; response to estrogen [GO:0043627]; response to immobilization stress [GO:0035902]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; secretory granule [GO:0030141]	galanin receptor activity [GO:0004966]; galanin receptor binding [GO:0031763]; neuropeptide hormone activity [GO:0005184]; type 1 galanin receptor binding [GO:0031764]; type 2 galanin receptor binding [GO:0031765]; type 3 galanin receptor binding [GO:0031766]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; secretory granule [GO:0030141]; galanin receptor activity [GO:0004966]; galanin receptor binding [GO:0031763]; neuropeptide hormone activity [GO:0005184]; type 1 galanin receptor binding [GO:0031764]; type 2 galanin receptor binding [GO:0031765]; type 3 galanin receptor binding [GO:0031766]; cAMP-mediated signaling [GO:0019933]; feeding behavior [GO:0007631]; insulin secretion [GO:0030073]; negative regulation of lymphocyte proliferation [GO:0050672]; neuropeptide signaling pathway [GO:0007218]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cortisol secretion [GO:0051464]; positive regulation of large conductance calcium-activated potassium channel activity [GO:1902608]; positive regulation of timing of catagen [GO:0051795]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein kinase A signaling [GO:0010737]; regulation of glucocorticoid metabolic process [GO:0031943]; response to estrogen [GO:0043627]; response to immobilization stress [GO:0035902]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1370155, ECO:0000269|PubMed:1722333}.
P22492	reviewed	H1T_HUMAN	Histone H1t (Testicular H1 histone)	H1-6 H1FT H1T HIST1H1T	Homo sapiens (Human)	207	FUNCTION: Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable). {ECO:0000269|PubMed:26757249, ECO:0000305}.		cell differentiation [GO:0030154]; chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	nucleosome [GO:0000786]; nucleus [GO:0005634]	double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; structural constituent of chromatin [GO:0030527]	nucleosome [GO:0000786]; nucleus [GO:0005634]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; structural constituent of chromatin [GO:0030527]; cell differentiation [GO:0030154]; chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
P22528	reviewed	SPR1B_HUMAN	Cornifin-B (14.9 kDa pancornulin) (Small proline-rich protein IB) (SPR-IB)	SPRR1B	Homo sapiens (Human)	89	FUNCTION: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.		epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	structural molecule activity [GO:0005198]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; structural molecule activity [GO:0005198]; epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]	SUBCELLULAR LOCATION: Cytoplasm.
P22557	reviewed	HEM0_HUMAN	5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS-E) (EC 2.3.1.37) (5-aminolevulinic acid synthase 2) (Delta-ALA synthase 2) (Delta-aminolevulinate synthase 2)	ALAS2 ALASE ASB	Homo sapiens (Human)	587	FUNCTION: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:14643893, PubMed:32499479, PubMed:21252495, PubMed:21653323, PubMed:21309041). Contributes significantly to heme formation during erythropoiesis (PubMed:2050125). {ECO:0000269|PubMed:14643893, ECO:0000269|PubMed:21252495, ECO:0000269|PubMed:21309041, ECO:0000269|PubMed:21653323, ECO:0000269|PubMed:32499479, ECO:0000303|PubMed:2050125}.; FUNCTION: [Isoform 3]: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:14643893). Catalytic activity is 75-85% of isoform 1 activity (PubMed:14643893). {ECO:0000269|PubMed:14643893}.; FUNCTION: [Isoform 4]: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:14643893). Catalytic activity is 65-75% of isoform 1 activity (PubMed:14643893). {ECO:0000269|PubMed:14643893}.		erythrocyte development [GO:0048821]; erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; hemoglobin biosynthetic process [GO:0042541]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to hypoxia [GO:0001666]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	5-aminolevulinate synthase activity [GO:0003870]; pyridoxal phosphate binding [GO:0030170]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 5-aminolevulinate synthase activity [GO:0003870]; pyridoxal phosphate binding [GO:0030170]; erythrocyte development [GO:0048821]; erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; hemoglobin biosynthetic process [GO:0042541]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:14643893}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the matrix side of the mitochondrion inner membrane. {ECO:0000269|PubMed:14643893}.; SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion inner membrane {ECO:0000269|PubMed:14643893}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the matrix side of the mitochondrion inner membrane. {ECO:0000269|PubMed:14643893}.
P22570	reviewed	ADRO_HUMAN	NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase)	FDXR ADXR	Homo sapiens (Human)	491	FUNCTION: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. {ECO:0000250|UniProtKB:P08165}.	MISCELLANEOUS: [Isoform Long]: Represents 10-20% of all adrenodoxin reductase mRNAs and seems to be inactive. {ECO:0000305}.	cholesterol metabolic process [GO:0008203]; generation of precursor metabolites and energy [GO:0006091]; steroid biosynthetic process [GO:0006694]; ubiquinone biosynthetic process [GO:0006744]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ferredoxin-NADP+ reductase activity [GO:0004324]; NADPH-adrenodoxin reductase activity [GO:0015039]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ferredoxin-NADP+ reductase activity [GO:0004324]; NADPH-adrenodoxin reductase activity [GO:0015039]; cholesterol metabolic process [GO:0008203]; generation of precursor metabolites and energy [GO:0006091]; steroid biosynthetic process [GO:0006694]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P48360}; Peripheral membrane protein {ECO:0000305}.
P22607	reviewed	FGFR3_HUMAN	Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)	FGFR3 JTK4	Homo sapiens (Human)	806	FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269|PubMed:10611230, ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:11703096, ECO:0000269|PubMed:14534538, ECO:0000269|PubMed:16410555, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17145761, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:19286672, ECO:0000269|PubMed:8663044}.		bone maturation [GO:0070977]; bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; cell-cell signaling [GO:0007267]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; endochondral bone growth [GO:0003416]; endochondral ossification [GO:0001958]; fibroblast growth factor receptor apoptotic signaling pathway [GO:1902178]; fibroblast growth factor receptor signaling pathway [GO:0008543]; MAPK cascade [GO:0000165]; negative regulation of developmental growth [GO:0048640]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; skeletal system development [GO:0001501]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transport vesicle [GO:0030133]	ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; identical protein binding [GO:0042802]; protein tyrosine kinase activity [GO:0004713]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transport vesicle [GO:0030133]; ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; identical protein binding [GO:0042802]; protein tyrosine kinase activity [GO:0004713]; bone maturation [GO:0070977]; bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; cell-cell signaling [GO:0007267]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; endochondral bone growth [GO:0003416]; endochondral ossification [GO:0001958]; fibroblast growth factor receptor apoptotic signaling pathway [GO:1902178]; fibroblast growth factor receptor signaling pathway [GO:0008543]; MAPK cascade [GO:0000165]; negative regulation of developmental growth [GO:0048640]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; skeletal system development [GO:0001501]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. Note=The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
P22612	reviewed	KAPCG_HUMAN	cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11)	PRKACG	Homo sapiens (Human)	351	FUNCTION: Phosphorylates a large number of substrates in the cytoplasm and the nucleus.		high-density lipoprotein particle assembly [GO:0034380]; male gonad development [GO:0008584]; phosphorylation [GO:0016310]; protein kinase A signaling [GO:0010737]; renal water homeostasis [GO:0003091]; spermatogenesis [GO:0007283]	cAMP-dependent protein kinase complex [GO:0005952]; ciliary base [GO:0097546]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; protein kinase A regulatory subunit binding [GO:0034237]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cAMP-dependent protein kinase complex [GO:0005952]; ciliary base [GO:0097546]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; protein kinase A regulatory subunit binding [GO:0034237]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; high-density lipoprotein particle assembly [GO:0034380]; male gonad development [GO:0008584]; phosphorylation [GO:0016310]; protein kinase A signaling [GO:0010737]; renal water homeostasis [GO:0003091]; spermatogenesis [GO:0007283]	
P22626	reviewed	ROA2_HUMAN	Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)	HNRNPA2B1 HNRPA2B1	Homo sapiens (Human)	353	FUNCTION: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}.		G-quadruplex DNA unwinding [GO:0044806]; miRNA transport [GO:1990428]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of telomerase RNA reverse transcriptase activity [GO:1905663]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; primary miRNA processing [GO:0031053]; RNA transport [GO:0050658]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]	G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; N6-methyladenosine-containing RNA binding [GO:1990247]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; single-stranded telomeric DNA binding [GO:0043047]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; N6-methyladenosine-containing RNA binding [GO:1990247]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; single-stranded telomeric DNA binding [GO:0043047]; G-quadruplex DNA unwinding [GO:0044806]; miRNA transport [GO:1990428]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of telomerase RNA reverse transcriptase activity [GO:1905663]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; primary miRNA processing [GO:0031053]; RNA transport [GO:0050658]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31320558}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17289661}. Cytoplasm {ECO:0000269|PubMed:31320558}. Cytoplasmic granule {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:24356509}. Secreted, extracellular exosome {ECO:0000269|PubMed:24356509}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Component of ribonucleosomes (PubMed:17289661). Not found in the nucleolus (PubMed:17289661). Found in exosomes following sumoylation (PubMed:24356509). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:24356509}.; SUBCELLULAR LOCATION: [Isoform A2]: Nucleus {ECO:0000269|PubMed:10772824, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:24098712}. Cytoplasm {ECO:0000269|PubMed:10772824, ECO:0000269|PubMed:17289661}. Note=Predominantly nucleoplasmic, however is also found in the cytoplasm of cells in some tissues (PubMed:17289661). {ECO:0000269|PubMed:17289661}.
P22670	reviewed	RFX1_HUMAN	MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1)	RFX1	Homo sapiens (Human)	979	FUNCTION: Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.		immune response [GO:0006955]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; immune response [GO:0006955]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P22674	reviewed	CCNO_HUMAN	Cyclin-O	CCNO	Homo sapiens (Human)	350	FUNCTION: Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking. {ECO:0000269|PubMed:24747639, ECO:0000269|PubMed:26777464}.		cell division [GO:0051301]; cilium assembly [GO:0060271]; mitotic cell cycle [GO:0000278]; mitotic cell cycle phase transition [GO:0044772]; multi-ciliated epithelial cell differentiation [GO:1903251]; response to xenobiotic stimulus [GO:0009410]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; cell division [GO:0051301]; cilium assembly [GO:0060271]; mitotic cell cycle [GO:0000278]; mitotic cell cycle phase transition [GO:0044772]; multi-ciliated epithelial cell differentiation [GO:1903251]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24747639}. Nucleus, nucleolus {ECO:0000269|PubMed:28860486, ECO:0000269|PubMed:30087414}. Note=Localizes to the apical part of cytoplasm. {ECO:0000269|PubMed:24747639}.
P22680	reviewed	CP7A1_HUMAN	Cytochrome P450 7A1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cholesterol 7-alpha-monooxygenase) (EC 1.14.14.23)	CYP7A1 CYP7	Homo sapiens (Human)	504	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:2384150, PubMed:21813643). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:2384150, PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:21813643). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (PubMed:12077124, PubMed:19965590, PubMed:2384150). 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol (PubMed:11013305, PubMed:12077124). Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (PubMed:21813643). {ECO:0000269|PubMed:11013305, ECO:0000269|PubMed:12077124, ECO:0000269|PubMed:19965590, ECO:0000269|PubMed:21813643, ECO:0000269|PubMed:2384150}.		bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; bile acid signaling pathway [GO:0038183]; cellular response to cholesterol [GO:0071397]; cellular response to glucose stimulus [GO:0071333]; cholesterol catabolic process [GO:0006707]; cholesterol homeostasis [GO:0042632]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of fatty acid biosynthetic process [GO:0045717]; positive regulation of cholesterol biosynthetic process [GO:0045542]; regulation of bile acid biosynthetic process [GO:0070857]; response to ethanol [GO:0045471]; sterol metabolic process [GO:0016125]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	24-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033782]; cholesterol 7-alpha-monooxygenase activity [GO:0008123]; heme binding [GO:0020037]; iron ion binding [GO:0005506]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; 24-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033782]; cholesterol 7-alpha-monooxygenase activity [GO:0008123]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; bile acid signaling pathway [GO:0038183]; cellular response to cholesterol [GO:0071397]; cellular response to glucose stimulus [GO:0071333]; cholesterol catabolic process [GO:0006707]; cholesterol homeostasis [GO:0042632]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of fatty acid biosynthetic process [GO:0045717]; positive regulation of cholesterol biosynthetic process [GO:0045542]; regulation of bile acid biosynthetic process [GO:0070857]; response to ethanol [GO:0045471]; sterol metabolic process [GO:0016125]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:11013305, ECO:0000305|PubMed:2384150}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305|PubMed:11013305, ECO:0000305|PubMed:2384150}; Single-pass membrane protein {ECO:0000305}.
P22681	reviewed	CBL_HUMAN	E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)	CBL CBL2 RNF55	Homo sapiens (Human)	906	FUNCTION: Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:17094949). Ubiquitinates SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates EGFR (PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750}.	MISCELLANEOUS: This protein has one functional calcium-binding site.	cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to oxygen-glucose deprivation [GO:0090650]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage response [GO:0006974]; entry of bacterium into host cell [GO:0035635]; male gonad development [GO:0008584]; mast cell degranulation [GO:0043303]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein ubiquitination [GO:0016567]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; regulation of Rap protein signal transduction [GO:0032487]; response to activity [GO:0014823]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]; signal transduction [GO:0007165]; ubiquitin-dependent endocytosis [GO:0070086]; ubiquitin-dependent protein catabolic process [GO:0006511]	cilium [GO:0005929]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; ephrin receptor binding [GO:0046875]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cilium [GO:0005929]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; ephrin receptor binding [GO:0046875]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to oxygen-glucose deprivation [GO:0090650]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage response [GO:0006974]; entry of bacterium into host cell [GO:0035635]; male gonad development [GO:0008584]; mast cell degranulation [GO:0043303]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein ubiquitination [GO:0016567]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; regulation of Rap protein signal transduction [GO:0032487]; response to activity [GO:0014823]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]; signal transduction [GO:0007165]; ubiquitin-dependent endocytosis [GO:0070086]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Cell projection, cilium {ECO:0000269|PubMed:29237719}. Golgi apparatus {ECO:0000269|PubMed:29237719}. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane.
P22692	reviewed	IBP4_HUMAN	Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4)	IGFBP4 IBP4	Homo sapiens (Human)	258	FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.		MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAPK cascade [GO:0043410]; regulation of cell growth [GO:0001558]; regulation of glucose metabolic process [GO:0010906]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]; type B pancreatic cell proliferation [GO:0044342]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102]; MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAPK cascade [GO:0043410]; regulation of cell growth [GO:0001558]; regulation of glucose metabolic process [GO:0010906]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Secreted.
P22694	reviewed	KAPCB_HUMAN	cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)	PRKACB	Homo sapiens (Human)	351	FUNCTION: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}.	MISCELLANEOUS: [Isoform 3]: Incomplete sequence. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Incomplete sequence. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Incomplete sequence. {ECO:0000305}.	adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; high-density lipoprotein particle assembly [GO:0034380]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; negative regulation of TORC1 signaling [GO:1904262]; neural tube closure [GO:0001843]; protein kinase A signaling [GO:0010737]; protein phosphorylation [GO:0006468]; regulation of protein processing [GO:0070613]; renal water homeostasis [GO:0003091]; signal transduction [GO:0007165]	cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase binding [GO:0031625]	cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase binding [GO:0031625]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; high-density lipoprotein particle assembly [GO:0034380]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; negative regulation of TORC1 signaling [GO:1904262]; neural tube closure [GO:0001843]; protein kinase A signaling [GO:0010737]; protein phosphorylation [GO:0006468]; regulation of protein processing [GO:0070613]; renal water homeostasis [GO:0003091]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Nucleus {ECO:0000250|UniProtKB:P05131}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. {ECO:0000250|UniProtKB:P05131}.
P22695	reviewed	QCR2_HUMAN	Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2)	UQCRC2	Homo sapiens (Human)	453	FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). {ECO:0000250|UniProtKB:P07257, ECO:0000250|UniProtKB:P23004, ECO:0000305|PubMed:29243944}.		aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]; proteolysis [GO:0006508]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07257}; Peripheral membrane protein {ECO:0000250|UniProtKB:P07257}; Matrix side {ECO:0000250|UniProtKB:P07257}.
P22732	reviewed	GTR5_HUMAN	Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)	SLC2A5 GLUT5	Homo sapiens (Human)	501	FUNCTION: Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543, PubMed:16186102, PubMed:28083649, PubMed:17710649, PubMed:29548810). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity). {ECO:0000250|UniProtKB:Q9WV38, ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:1695905, ECO:0000269|PubMed:17710649, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:29548810, ECO:0000269|PubMed:8333543}.		carbohydrate metabolic process [GO:0005975]; cellular response to fructose stimulus [GO:0071332]; fructose import across plasma membrane [GO:1990539]; fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; intestinal hexose absorption [GO:0106001]; regulation of systemic arterial blood pressure mediated by a chemical signal [GO:0003044]; response to fructose [GO:0009750]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; specific granule membrane [GO:0035579]	fructose binding [GO:0070061]; fructose transmembrane transporter activity [GO:0005353]; glucose transmembrane transporter activity [GO:0005355]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; specific granule membrane [GO:0035579]; fructose binding [GO:0070061]; fructose transmembrane transporter activity [GO:0005353]; glucose transmembrane transporter activity [GO:0005355]; carbohydrate metabolic process [GO:0005975]; cellular response to fructose stimulus [GO:0071332]; fructose import across plasma membrane [GO:1990539]; fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; intestinal hexose absorption [GO:0106001]; regulation of systemic arterial blood pressure mediated by a chemical signal [GO:0003044]; response to fructose [GO:0009750]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9WV38}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WV38}. Cell membrane {ECO:0000269|PubMed:1695905, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:7619085, ECO:0000269|PubMed:8333543}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WV38}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P43427}. Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A. {ECO:0000250|UniProtKB:Q9WV38}.
P22735	reviewed	TGM1_HUMAN	Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1)	TGM1 KTG	Homo sapiens (Human)	817	FUNCTION: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141). {ECO:0000269|PubMed:26220141}.		cell envelope organization [GO:0043163]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838]; protein modification process [GO:0036211]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; cell envelope organization [GO:0043163]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17762858}; Lipid-anchor {ECO:0000305|PubMed:17762858}.
P22736	reviewed	NR4A1_HUMAN	Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)	NR4A1 GFRP1 HMR NAK1	Homo sapiens (Human)	598	FUNCTION: Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:9315652, PubMed:8121493). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}.		apoptotic process [GO:0006915]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; detection of lipopolysaccharide [GO:0032497]; endothelial cell chemotaxis [GO:0035767]; fat cell differentiation [GO:0045444]; inflammatory response [GO:0006954]; negative regulation of cell cycle [GO:0045786]; neurotransmitter secretion involved in regulation of skeletal muscle contraction [GO:0014860]; non-canonical inflammasome complex assembly [GO:0160075]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to amphetamine [GO:0001975]; response to electrical stimulus [GO:0051602]; signal transduction [GO:0007165]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynapse [GO:0098793]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynapse [GO:0098793]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; detection of lipopolysaccharide [GO:0032497]; endothelial cell chemotaxis [GO:0035767]; fat cell differentiation [GO:0045444]; inflammatory response [GO:0006954]; negative regulation of cell cycle [GO:0045786]; neurotransmitter secretion involved in regulation of skeletal muscle contraction [GO:0014860]; non-canonical inflammasome complex assembly [GO:0160075]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to amphetamine [GO:0001975]; response to electrical stimulus [GO:0051602]; signal transduction [GO:0007165]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:20438716, ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493}. Cytoplasm, cytosol {ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:20438716, ECO:0000269|PubMed:22427340}. Mitochondrion {ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18690216}. Note=Nuclear export to the cytosol is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). {ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:22427340}.
P22748	reviewed	CAH4_HUMAN	Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV)	CA4	Homo sapiens (Human)	312	FUNCTION: Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH (PubMed:15563508, PubMed:17652713, PubMed:7625839, PubMed:16807956, PubMed:16686544, PubMed:17705204, PubMed:17127057, PubMed:17314045, PubMed:19186056, PubMed:19206230, PubMed:18618712). May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis (PubMed:15563508). It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid (PubMed:15563508). {ECO:0000269|PubMed:15563508, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17652713, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:7625839}.		bicarbonate transport [GO:0015701]; one-carbon metabolic process [GO:0006730]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; transport vesicle membrane [GO:0030658]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; transport vesicle membrane [GO:0030658]; carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]; bicarbonate transport [GO:0015701]; one-carbon metabolic process [GO:0006730]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15563508}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:7625839}.
P22749	reviewed	GNLY_HUMAN	Granulysin (Lymphokine LAG-2) (Protein NKG5) (T-cell activation protein 519)	GNLY LAG2 NKG5 TLA519	Homo sapiens (Human)	145	FUNCTION: Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular defense response [GO:0006968]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; killing of cells of another organism [GO:0031640]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle lumen [GO:0097013]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle lumen [GO:0097013]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular defense response [GO:0006968]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; killing of cells of another organism [GO:0031640]	SUBCELLULAR LOCATION: Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.
P22760	reviewed	AAAD_HUMAN	Arylacetamide deacetylase (EC 3.1.1.3)	AADAC DAC	Homo sapiens (Human)	399	FUNCTION: Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000269|PubMed:17936933, ECO:0000269|PubMed:19339378, ECO:0000269|PubMed:22207054, ECO:0000269|PubMed:22415931, ECO:0000269|PubMed:23542347}.	MISCELLANEOUS: Can hydrolyze a number of clinical drugs such as flutamide, an antiandrogen drug used for the treatment of prostate cancer; phenacetin, an analgesic antipyretic which has been withdrawn from the market due to its links with renal failure; and rifamycins which have been used as antituberculosis drugs.	lipid metabolic process [GO:0006629]; positive regulation of triglyceride catabolic process [GO:0010898]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]	catalytic activity [GO:0003824]; deacetylase activity [GO:0019213]; lipase activity [GO:0016298]; serine hydrolase activity [GO:0017171]; triglyceride lipase activity [GO:0004806]	endoplasmic reticulum membrane [GO:0005789]; catalytic activity [GO:0003824]; deacetylase activity [GO:0019213]; lipase activity [GO:0016298]; serine hydrolase activity [GO:0017171]; triglyceride lipase activity [GO:0004806]; lipid metabolic process [GO:0006629]; positive regulation of triglyceride catabolic process [GO:0010898]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.
P22792	reviewed	CPN2_HUMAN	Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit)	CPN2 ACBP	Homo sapiens (Human)	545	FUNCTION: The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.		protein stabilization [GO:0050821]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	enzyme regulator activity [GO:0030234]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; enzyme regulator activity [GO:0030234]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Secreted.
P22794	reviewed	EVI2A_HUMAN	Protein EVI2A (Ecotropic viral integration site 2A protein homolog) (EVI-2A)	EVI2A EVDA EVI2	Homo sapiens (Human)	236	FUNCTION: May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.			membrane [GO:0016020]	transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; transmembrane signaling receptor activity [GO:0004888]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P22830	reviewed	HEMH_HUMAN	Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase)	FECH	Homo sapiens (Human)	423	FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX. {ECO:0000269|PubMed:27599036, ECO:0000269|PubMed:8276824}.		cellular response to dexamethasone stimulus [GO:0071549]; cholesterol metabolic process [GO:0008203]; detection of UV [GO:0009589]; erythrocyte differentiation [GO:0030218]; generation of precursor metabolites and energy [GO:0006091]; heme biosynthetic process [GO:0006783]; multicellular organismal-level iron ion homeostasis [GO:0060586]; protoporphyrinogen IX metabolic process [GO:0046501]; regulation of eIF2 alpha phosphorylation by heme [GO:0010999]; regulation of hemoglobin biosynthetic process [GO:0046984]; response to arsenic-containing substance [GO:0046685]; response to ethanol [GO:0045471]; response to insecticide [GO:0017085]; response to lead ion [GO:0010288]; response to light stimulus [GO:0009416]; response to methylmercury [GO:0051597]; response to platinum ion [GO:0070541]; response to xenobiotic stimulus [GO:0009410]; very-low-density lipoprotein particle assembly [GO:0034379]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	2 iron, 2 sulfur cluster binding [GO:0051537]; ferrochelatase activity [GO:0004325]; ferrous iron binding [GO:0008198]; heme binding [GO:0020037]; iron-responsive element binding [GO:0030350]; protein homodimerization activity [GO:0042803]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; ferrochelatase activity [GO:0004325]; ferrous iron binding [GO:0008198]; heme binding [GO:0020037]; iron-responsive element binding [GO:0030350]; protein homodimerization activity [GO:0042803]; cellular response to dexamethasone stimulus [GO:0071549]; cholesterol metabolic process [GO:0008203]; detection of UV [GO:0009589]; erythrocyte differentiation [GO:0030218]; generation of precursor metabolites and energy [GO:0006091]; heme biosynthetic process [GO:0006783]; multicellular organismal-level iron ion homeostasis [GO:0060586]; protoporphyrinogen IX metabolic process [GO:0046501]; regulation of eIF2 alpha phosphorylation by heme [GO:0010999]; regulation of hemoglobin biosynthetic process [GO:0046984]; response to arsenic-containing substance [GO:0046685]; response to ethanol [GO:0045471]; response to insecticide [GO:0017085]; response to lead ion [GO:0010288]; response to light stimulus [GO:0009416]; response to methylmercury [GO:0051597]; response to platinum ion [GO:0070541]; response to xenobiotic stimulus [GO:0009410]; very-low-density lipoprotein particle assembly [GO:0034379]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
P22888	reviewed	LSHR_HUMAN	Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R)	LHCGR LCGR LGR2 LHRHR	Homo sapiens (Human)	699	FUNCTION: Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). {ECO:0000269|PubMed:11847099}.		activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; arachidonic acid secretion [GO:0050482]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to luteinizing hormone stimulus [GO:0071373]; cognition [GO:0050890]; development of secondary male sexual characteristics [GO:0046544]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated signaling pathway [GO:0009755]; luteinizing hormone signaling pathway [GO:0042700]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; ovarian follicle development [GO:0001541]; ovulation cycle process [GO:0022602]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; protein targeting to lysosome [GO:0006622]; regulation of steroid hormone biosynthetic process [GO:0090030]; response to xenobiotic stimulus [GO:0009410]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283]; uterus development [GO:0060065]	centriolar satellite [GO:0034451]; endosome [GO:0005768]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATPase binding [GO:0051117]; choriogonadotropin hormone binding [GO:0038106]; choriogonadotropin hormone receptor activity [GO:0035472]; G protein-coupled peptide receptor activity [GO:0008528]; identical protein binding [GO:0042802]; luteinizing hormone receptor activity [GO:0004964]; peptide hormone binding [GO:0017046]	centriolar satellite [GO:0034451]; endosome [GO:0005768]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATPase binding [GO:0051117]; choriogonadotropin hormone binding [GO:0038106]; choriogonadotropin hormone receptor activity [GO:0035472]; G protein-coupled peptide receptor activity [GO:0008528]; identical protein binding [GO:0042802]; luteinizing hormone receptor activity [GO:0004964]; peptide hormone binding [GO:0017046]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; arachidonic acid secretion [GO:0050482]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to luteinizing hormone stimulus [GO:0071373]; cognition [GO:0050890]; development of secondary male sexual characteristics [GO:0046544]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated signaling pathway [GO:0009755]; luteinizing hormone signaling pathway [GO:0042700]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; ovarian follicle development [GO:0001541]; ovulation cycle process [GO:0022602]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; protein targeting to lysosome [GO:0006622]; regulation of steroid hormone biosynthetic process [GO:0090030]; response to xenobiotic stimulus [GO:0009410]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283]; uterus development [GO:0060065]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11847099}; Multi-pass membrane protein {ECO:0000305}.
P22891	reviewed	PROZ_HUMAN	Vitamin K-dependent protein Z	PROZ	Homo sapiens (Human)	400	FUNCTION: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.		blood coagulation [GO:0007596]; proteolysis [GO:0006508]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]	calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; blood coagulation [GO:0007596]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
P22894	reviewed	MMP8_HUMAN	Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL)	MMP8 CLG1	Homo sapiens (Human)	467	FUNCTION: Can degrade fibrillar type I, II, and III collagens.		cellular response to lipopolysaccharide [GO:0071222]; collagen catabolic process [GO:0030574]; endodermal cell differentiation [GO:0035987]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteolysis [GO:0006508]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; tumor necrosis factor binding [GO:0043120]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; tumor necrosis factor binding [GO:0043120]; zinc ion binding [GO:0008270]; cellular response to lipopolysaccharide [GO:0071222]; collagen catabolic process [GO:0030574]; endodermal cell differentiation [GO:0035987]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasmic granule. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Note=Stored in intracellular granules.
P22897	reviewed	MRC1_HUMAN	Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206)	MRC1 CLEC13D CLEC13DL MRC1L1	Homo sapiens (Human)	1456	FUNCTION: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; FUNCTION: (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.; FUNCTION: (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. {ECO:0000269|PubMed:18266465}.; FUNCTION: (Microbial infection) Interacts with Hepatitis B virus envelope protein. {ECO:0000269|PubMed:19683778}.		cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; receptor-mediated endocytosis [GO:0006898]	cell surface [GO:0009986]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	cargo receptor activity [GO:0038024]; mannose binding [GO:0005537]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; cargo receptor activity [GO:0038024]; mannose binding [GO:0005537]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:20035344}; Single-pass type I membrane protein {ECO:0000269|PubMed:20035344}. Cell membrane {ECO:0000269|PubMed:20035344}; Single-pass type I membrane protein {ECO:0000269|PubMed:20035344}.
P22914	reviewed	CRYGS_HUMAN	Gamma-crystallin S (Beta-crystallin S) (Gamma-S-crystallin)	CRYGS CRYG8	Homo sapiens (Human)	178	FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.		lens development in camera-type eye [GO:0002088]; morphogenesis of an epithelium [GO:0002009]; visual perception [GO:0007601]		structural constituent of eye lens [GO:0005212]	structural constituent of eye lens [GO:0005212]; lens development in camera-type eye [GO:0002088]; morphogenesis of an epithelium [GO:0002009]; visual perception [GO:0007601]	
P23025	reviewed	XPA_HUMAN	DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein)	XPA XPAC	Homo sapiens (Human)	273	FUNCTION: Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. {ECO:0000269|PubMed:19197159}.		base-excision repair [GO:0006284]; DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair involved in interstrand cross-link repair [GO:1901255]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; protein localization to nucleus [GO:0034504]; response to auditory stimulus [GO:0010996]; UV protection [GO:0009650]; UV-damage excision repair [GO:0070914]	intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleotide-excision repair factor 1 complex [GO:0000110]; nucleus [GO:0005634]	damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; sequence-specific double-stranded DNA binding [GO:1990837]	intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleotide-excision repair factor 1 complex [GO:0000110]; nucleus [GO:0005634]; damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; sequence-specific double-stranded DNA binding [GO:1990837]; base-excision repair [GO:0006284]; DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair involved in interstrand cross-link repair [GO:1901255]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; protein localization to nucleus [GO:0034504]; response to auditory stimulus [GO:0010996]; UV protection [GO:0009650]; UV-damage excision repair [GO:0070914]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1918083, ECO:0000269|PubMed:19197159, ECO:0000269|PubMed:20304803}.
P23083	reviewed	HV102_HUMAN	Immunoglobulin heavy variable 1-2 (Ig heavy chain V-I region ND) (Ig heavy chain V-I region V35)	IGHV1-2	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P23109	reviewed	AMPD1_HUMAN	AMP deaminase 1 (EC 3.5.4.6) (AMP deaminase isoform M) (Myoadenylate deaminase)	AMPD1	Homo sapiens (Human)	747	FUNCTION: AMP deaminase plays a critical role in energy metabolism. {ECO:0000269|PubMed:11102975}.		AMP metabolic process [GO:0046033]; GMP salvage [GO:0032263]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264]	cytosol [GO:0005829]	AMP deaminase activity [GO:0003876]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; AMP deaminase activity [GO:0003876]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; AMP metabolic process [GO:0046033]; GMP salvage [GO:0032263]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264]	
P23141	reviewed	EST1_HUMAN	Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cholesteryl ester hydrolase) (CEH) (EC 3.1.1.13) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH)	CES1 CES2 SES1	Homo sapiens (Human)	567	FUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:7980644, PubMed:9169443, PubMed:9490062, PubMed:18762277). Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester (PubMed:7980644, PubMed:9169443, PubMed:9490062, PubMed:18762277). Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine (PubMed:7980644). Catalyzes the transesterification of cocaine to form cocaethylene (PubMed:7980644). Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate (PubMed:7980644). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984). Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process (PubMed:18762277, PubMed:16024911, PubMed:11015575, PubMed:16971496). First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile (PubMed:18762277, PubMed:18599737, PubMed:16971496). {ECO:0000269|PubMed:11015575, ECO:0000269|PubMed:16024911, ECO:0000269|PubMed:16971496, ECO:0000269|PubMed:18599737, ECO:0000269|PubMed:18762277, ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062}.		cellular response to cholesterol [GO:0071397]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol biosynthetic process [GO:0006695]; cholesterol ester hydrolysis involved in cholesterol transport [GO:0090122]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; epithelial cell differentiation [GO:0030855]; lipid catabolic process [GO:0016042]; medium-chain fatty acid metabolic process [GO:0051791]; negative regulation of cholesterol storage [GO:0010887]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of bile acid secretion [GO:0120188]; response to toxic substance [GO:0009636]; reverse cholesterol transport [GO:0043691]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; lipid droplet [GO:0005811]	carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; sterol esterase activity [GO:0004771]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; lipid droplet [GO:0005811]; carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; sterol esterase activity [GO:0004771]; cellular response to cholesterol [GO:0071397]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol biosynthetic process [GO:0006695]; cholesterol ester hydrolysis involved in cholesterol transport [GO:0090122]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; epithelial cell differentiation [GO:0030855]; lipid catabolic process [GO:0016042]; medium-chain fatty acid metabolic process [GO:0051791]; negative regulation of cholesterol storage [GO:0010887]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of bile acid secretion [GO:0120188]; response to toxic substance [GO:0009636]; reverse cholesterol transport [GO:0043691]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:10562416}. Cytoplasm {ECO:0000269|PubMed:16024911}. Lipid droplet {ECO:0000269|PubMed:16024911}. Note=Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the droplets and hydrolyzes cholesteryl esters more efficiently from mixed droplets. {ECO:0000269|PubMed:16024911}.
P23142	reviewed	FBLN1_HUMAN	Fibulin-1 (FIBL-1)	FBLN1 PP213	Homo sapiens (Human)	703	FUNCTION: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}.		blood coagulation, fibrin clot formation [GO:0072378]; embryo implantation [GO:0007566]; extracellular matrix organization [GO:0030198]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell motility [GO:2000146]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; negative regulation of transformation of host cell by virus [GO:1904188]; negative regulation of transforming growth factor beta production [GO:0071635]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; fibrinogen binding [GO:0070051]; fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activator activity [GO:0016504]; protein-containing complex binding [GO:0044877]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; fibrinogen binding [GO:0070051]; fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activator activity [GO:0016504]; protein-containing complex binding [GO:0044877]; blood coagulation, fibrin clot formation [GO:0072378]; embryo implantation [GO:0007566]; extracellular matrix organization [GO:0030198]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell motility [GO:2000146]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; negative regulation of transformation of host cell by virus [GO:1904188]; negative regulation of transforming growth factor beta production [GO:0071635]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
P23193	reviewed	TCEA1_HUMAN	Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o)	TCEA1 GTF2S TFIIS	Homo sapiens (Human)	301	FUNCTION: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.	MISCELLANEOUS: S-II binds to RNA-polymerase II in the absence of transcription.	DNA-templated transcription [GO:0006351]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; DNA-templated transcription [GO:0006351]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus.
P23219	reviewed	PGH1_HUMAN	Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1)	PTGS1 COX1	Homo sapiens (Human)	599	FUNCTION: Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975). Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (By similarity). {ECO:0000250|UniProtKB:P05979, ECO:0000269|PubMed:7947975, ECO:0000305|PubMed:10966456, ECO:0000305|PubMed:24605250}.	MISCELLANEOUS: The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.; MISCELLANEOUS: Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.; MISCELLANEOUS: PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.	cyclooxygenase pathway [GO:0019371]; prostaglandin biosynthetic process [GO:0001516]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127]; response to oxidative stress [GO:0006979]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; photoreceptor outer segment [GO:0001750]	heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; peroxidase activity [GO:0004601]; prostaglandin-endoperoxide synthase activity [GO:0004666]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; photoreceptor outer segment [GO:0001750]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; peroxidase activity [GO:0004601]; prostaglandin-endoperoxide synthase activity [GO:0004666]; cyclooxygenase pathway [GO:0019371]; prostaglandin biosynthetic process [GO:0001516]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
P23229	reviewed	ITA6_HUMAN	Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)]	ITGA6	Homo sapiens (Human)	1130	FUNCTION: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000250|UniProtKB:Q61739, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.		cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to organic cyclic compound [GO:0071407]; ectodermal cell differentiation [GO:0010668]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; nail development [GO:0035878]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skin morphogenesis [GO:0043589]	adherens junction [GO:0005912]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; integrin alpha6-beta4 complex [GO:0034676]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; insulin-like growth factor I binding [GO:0031994]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; neuregulin binding [GO:0038132]	adherens junction [GO:0005912]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; integrin alpha6-beta4 complex [GO:0034676]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; insulin-like growth factor I binding [GO:0031994]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; neuregulin binding [GO:0038132]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to organic cyclic compound [GO:0071407]; ectodermal cell differentiation [GO:0010668]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; nail development [GO:0035878]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skin morphogenesis [GO:0043589]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22314500}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:22314500}; Lipid-anchor {ECO:0000269|PubMed:22314500}.
P23246	reviewed	SFPQ_HUMAN	Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)	SFPQ PSF	Homo sapiens (Human)	707	FUNCTION: DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}.		activation of innate immune response [GO:0002218]; alternative mRNA splicing, via spliceosome [GO:0000380]; chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]; activation of innate immune response [GO:0002218]; alternative mRNA splicing, via spliceosome [GO:0000380]; chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:25765647}. Nucleus matrix {ECO:0000269|PubMed:10653975, ECO:0000269|PubMed:19439179, ECO:0000269|PubMed:9848648}. Cytoplasm {ECO:0000269|PubMed:19439179}. Note=Predominantly in nuclear matrix. {ECO:0000269|PubMed:19439179}.
P23258	reviewed	TBG1_HUMAN	Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1)	TUBG1 TUBG	Homo sapiens (Human)	451	FUNCTION: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.		cytoplasmic microtubule organization [GO:0031122]; meiotic spindle organization [GO:0000212]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052]	apical part of cell [GO:0045177]; cell leading edge [GO:0031252]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; microtubule [GO:0005874]; mitotic spindle microtubule [GO:1990498]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; polar microtubule [GO:0005827]; recycling endosome [GO:0055037]; spindle [GO:0005819]	GTP binding [GO:0005525]; identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200]	apical part of cell [GO:0045177]; cell leading edge [GO:0031252]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; microtubule [GO:0005874]; mitotic spindle microtubule [GO:1990498]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; polar microtubule [GO:0005827]; recycling endosome [GO:0055037]; spindle [GO:0005819]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200]; cytoplasmic microtubule organization [GO:0031122]; meiotic spindle organization [GO:0000212]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:24107630, ECO:0000269|PubMed:9566967, ECO:0000269|PubMed:9566969}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:30723163}. Note=Localizes to mitotic spindle microtubules. {ECO:0000269|PubMed:30723163}.
P23276	reviewed	KELL_HUMAN	Kell blood group glycoprotein (EC 3.4.24.-) (CD antigen CD238)	KEL	Homo sapiens (Human)	732	FUNCTION: Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. {ECO:0000269|PubMed:10438732}.		establishment of localization in cell [GO:0051649]; intracellular calcium ion homeostasis [GO:0006874]; intracellular magnesium ion homeostasis [GO:0010961]; myelination [GO:0042552]; negative regulation of potassium ion transmembrane transport [GO:1901380]; potassium ion transmembrane transport [GO:0071805]; protein processing [GO:0016485]; regulation of axon diameter [GO:0031133]; regulation of cell size [GO:0008361]; skeletal muscle fiber development [GO:0048741]; vasoconstriction [GO:0042310]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; establishment of localization in cell [GO:0051649]; intracellular calcium ion homeostasis [GO:0006874]; intracellular magnesium ion homeostasis [GO:0010961]; myelination [GO:0042552]; negative regulation of potassium ion transmembrane transport [GO:1901380]; potassium ion transmembrane transport [GO:0071805]; protein processing [GO:0016485]; regulation of axon diameter [GO:0031133]; regulation of cell size [GO:0008361]; skeletal muscle fiber development [GO:0048741]; vasoconstriction [GO:0042310]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.
P23280	reviewed	CAH6_HUMAN	Carbonic anhydrase 6 (EC 4.2.1.1) (Carbonate dehydratase VI) (Carbonic anhydrase VI) (CA-VI) (Salivary carbonic anhydrase) (Secreted carbonic anhydrase)	CA6	Homo sapiens (Human)	308	FUNCTION: Reversible hydration of carbon dioxide. Its role in saliva is unknown.		detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; one-carbon metabolic process [GO:0006730]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; one-carbon metabolic process [GO:0006730]	SUBCELLULAR LOCATION: Secreted.
P23284	reviewed	PPIB_HUMAN	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	PPIB CYPB	Homo sapiens (Human)	216	FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269|PubMed:20676357}.		bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; neutrophil chemotaxis [GO:0030593]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by host of viral process [GO:0044794]; positive regulation of multicellular organism growth [GO:0040018]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; protein stabilization [GO:0050821]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; smooth endoplasmic reticulum [GO:0005790]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; smooth endoplasmic reticulum [GO:0005790]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; unfolded protein binding [GO:0051082]; bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; neutrophil chemotaxis [GO:0030593]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by host of viral process [GO:0044794]; positive regulation of multicellular organism growth [GO:0040018]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:20147391}. Note=(Microbial infection).; SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:1530944}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065}.
P23297	reviewed	S10A1_HUMAN	Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)	S100A1 S100A	Homo sapiens (Human)	94	FUNCTION: Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446). {ECO:0000269|PubMed:11717446, ECO:0000269|PubMed:12804600, ECO:0000269|PubMed:22399290, ECO:0000269|PubMed:23351007}.	MISCELLANEOUS: Able to bind zinc in vitro; the binding sites are different from the calcium binding sites. The physiological relevance of zinc binding is unclear. Physiological concentrations of potassium antagonize the binding of both divalent cations, especially affecting the high-affinity calcium-binding sites. {ECO:0000250|UniProtKB:P02639}.	intracellular signal transduction [GO:0035556]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of heart contraction [GO:0008016]; substantia nigra development [GO:0021762]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; sarcoplasmic reticulum [GO:0016529]	ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; sarcoplasmic reticulum [GO:0016529]; ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]; intracellular signal transduction [GO:0035556]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of heart contraction [GO:0008016]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15171681}. Sarcoplasmic reticulum {ECO:0000269|PubMed:12804600}. Mitochondrion {ECO:0000250|UniProtKB:P56565}.
P23327	reviewed	SRCH_HUMAN	Sarcoplasmic reticulum histidine-rich calcium-binding protein	HRC HCP	Homo sapiens (Human)	699	FUNCTION: May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.		muscle contraction [GO:0006936]; positive regulation of heart contraction [GO:0045823]; positive regulation of heart rate [GO:0010460]; positive regulation of relaxation of cardiac muscle [GO:1901899]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]	endoplasmic reticulum lumen [GO:0005788]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018]	ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; transmembrane transporter binding [GO:0044325]	endoplasmic reticulum lumen [GO:0005788]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018]; ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; transmembrane transporter binding [GO:0044325]; muscle contraction [GO:0006936]; positive regulation of heart contraction [GO:0045823]; positive regulation of heart rate [GO:0010460]; positive regulation of relaxation of cardiac muscle [GO:1901899]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum lumen.
P23352	reviewed	KALM_HUMAN	Anosmin-1 (Adhesion molecule-like X-linked) (Kallmann syndrome protein)	ANOS1 ADMLX KAL KAL1 KALIG1	Homo sapiens (Human)	680	FUNCTION: Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. {ECO:0000250, ECO:0000269|PubMed:19696444}.		axon guidance [GO:0007411]; cell adhesion [GO:0007155]; chemotaxis [GO:0006935]; neuron differentiation [GO:0030182]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; chemotaxis [GO:0006935]; neuron differentiation [GO:0030182]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8842728}; Peripheral membrane protein {ECO:0000269|PubMed:8842728}. Secreted {ECO:0000269|PubMed:8842728}. Note=Proteolytic cleavage may release it from the cell surface into the extracellular space.
P23368	reviewed	MAOM_HUMAN	NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38) (Malic enzyme 2)	ME2	Homo sapiens (Human)	584	FUNCTION: NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate. {ECO:0000269|PubMed:12121650, ECO:0000269|PubMed:1993674}.	MISCELLANEOUS: This isoenzyme can also use NADP(+) but is more effective with NAD(+). {ECO:0000269|PubMed:12121650, ECO:0000269|PubMed:1993674}.	malate metabolic process [GO:0006108]; pyruvate metabolic process [GO:0006090]; regulation of NADP metabolic process [GO:1902031]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	electron transfer activity [GO:0009055]; malate dehydrogenase (decarboxylating) (NAD+) activity [GO:0004471]; malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; malic enzyme activity [GO:0004470]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; oxaloacetate decarboxylase activity [GO:0008948]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; electron transfer activity [GO:0009055]; malate dehydrogenase (decarboxylating) (NAD+) activity [GO:0004471]; malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; malic enzyme activity [GO:0004470]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; oxaloacetate decarboxylase activity [GO:0008948]; malate metabolic process [GO:0006108]; pyruvate metabolic process [GO:0006090]; regulation of NADP metabolic process [GO:1902031]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:1993674}.
P23378	reviewed	GCSP_HUMAN	Glycine dehydrogenase (decarboxylating), mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring))	GLDC GCSP	Homo sapiens (Human)	1020	FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH). {ECO:0000269|PubMed:1993704, ECO:0000269|PubMed:1996985, ECO:0000269|PubMed:28244183}.		cellular response to leukemia inhibitory factor [GO:1990830]; glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]; response to lipoic acid [GO:1903442]; response to methylamine [GO:0036255]	glycine cleavage complex [GO:0005960]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	electron transfer activity [GO:0009055]; glycine binding [GO:0016594]; glycine dehydrogenase (decarboxylating) activity [GO:0004375]; lyase activity [GO:0016829]; protein homodimerization activity [GO:0042803]; pyridoxal binding [GO:0070280]; pyridoxal phosphate binding [GO:0030170]	glycine cleavage complex [GO:0005960]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; glycine binding [GO:0016594]; glycine dehydrogenase (decarboxylating) activity [GO:0004375]; lyase activity [GO:0016829]; protein homodimerization activity [GO:0042803]; pyridoxal binding [GO:0070280]; pyridoxal phosphate binding [GO:0030170]; cellular response to leukemia inhibitory factor [GO:1990830]; glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]; response to lipoic acid [GO:1903442]; response to methylamine [GO:0036255]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:28244183}.
P23381	reviewed	SYWC_HUMAN	Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]	WARS1 IFI53 WARS WRS	Homo sapiens (Human)	471	FUNCTION: Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:14630953, ECO:0000269|PubMed:28369220}.		angiogenesis [GO:0001525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of gene expression [GO:0010628]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of angiogenesis [GO:0045765]; translation [GO:0006412]; tryptophanyl-tRNA aminoacylation [GO:0006436]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; kinase inhibitor activity [GO:0019210]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; tryptophan-tRNA ligase activity [GO:0004830]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; kinase inhibitor activity [GO:0019210]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; tryptophan-tRNA ligase activity [GO:0004830]; angiogenesis [GO:0001525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of gene expression [GO:0010628]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of angiogenesis [GO:0045765]; translation [GO:0006412]; tryptophanyl-tRNA aminoacylation [GO:0006436]	SUBCELLULAR LOCATION: Cytoplasm.
P23396	reviewed	RS3_HUMAN	Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18)	RPS3 OK/SW-cl.26	Homo sapiens (Human)	243	FUNCTION: Component of the small ribosomal subunit (PubMed:8706699, PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:8706699, PubMed:23636399). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}.		apoptotic process [GO:0006915]; base-excision repair [GO:0006284]; cell division [GO:0051301]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; chromosome segregation [GO:0007059]; cytoplasmic translation [GO:0002181]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of DNA repair [GO:0045738]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of translation [GO:0017148]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of base-excision repair [GO:1905053]; positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001272]; positive regulation of DNA repair [GO:0045739]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of apoptotic process [GO:0042981]; response to TNF agonist [GO:0061481]; spindle assembly [GO:0051225]; translation [GO:0006412]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitotic spindle [GO:0072686]; NF-kappaB complex [GO:0071159]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polysome [GO:0005844]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; ruffle membrane [GO:0032587]	class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron-sulfur cluster binding [GO:0051536]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; mRNA binding [GO:0003729]; oxidized purine DNA binding [GO:0032357]; oxidized pyrimidine DNA binding [GO:0032358]; protein kinase A binding [GO:0051018]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; supercoiled DNA binding [GO:0097100]; tubulin binding [GO:0015631]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitotic spindle [GO:0072686]; NF-kappaB complex [GO:0071159]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polysome [GO:0005844]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; ruffle membrane [GO:0032587]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron-sulfur cluster binding [GO:0051536]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; mRNA binding [GO:0003729]; oxidized purine DNA binding [GO:0032357]; oxidized pyrimidine DNA binding [GO:0032358]; protein kinase A binding [GO:0051018]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; supercoiled DNA binding [GO:0097100]; tubulin binding [GO:0015631]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; apoptotic process [GO:0006915]; base-excision repair [GO:0006284]; cell division [GO:0051301]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; chromosome segregation [GO:0007059]; cytoplasmic translation [GO:0002181]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of DNA repair [GO:0045738]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of translation [GO:0017148]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of base-excision repair [GO:1905053]; positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001272]; positive regulation of DNA repair [GO:0045739]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of apoptotic process [GO:0042981]; response to TNF agonist [GO:0061481]; spindle assembly [GO:0051225]; translation [GO:0006412]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16314389, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:17560175, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:21871177, ECO:0000269|PubMed:23636399}. Nucleus {ECO:0000269|PubMed:17560175, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:19460357, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:21871177}. Nucleus, nucleolus {ECO:0000269|PubMed:16314389, ECO:0000269|PubMed:19460357}. Mitochondrion inner membrane {ECO:0000269|PubMed:23911537}; Peripheral membrane protein {ECO:0000269|PubMed:23911537}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23131551}. Note=In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis (By similarity). Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Accumulates in the mitochondrion in response to increased ROS levels (PubMed:23911537). Localizes to the spindle during mitosis (PubMed:23131551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). {ECO:0000250|UniProtKB:P62908, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:17560175, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23911537}.
P23409	reviewed	MYF6_HUMAN	Myogenic factor 6 (Myf-6) (Class C basic helix-loop-helix protein 4) (bHLHc4) (Muscle-specific regulatory factor 4)	MYF6 BHLHC4 MRF4	Homo sapiens (Human)	242	FUNCTION: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.		muscle cell fate commitment [GO:0042693]; muscle tissue morphogenesis [GO:0060415]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; muscle cell fate commitment [GO:0042693]; muscle tissue morphogenesis [GO:0060415]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Nucleus.
P23415	reviewed	GLRA1_HUMAN	Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit)	GLRA1	Homo sapiens (Human)	457	FUNCTION: Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). {ECO:0000250|UniProtKB:Q64018, ECO:0000269|PubMed:14551753, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:2155780, ECO:0000269|PubMed:22715885, ECO:0000269|PubMed:22973015, ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:25730860, ECO:0000269|PubMed:25973519, ECO:0000269|PubMed:7920629, ECO:0000269|PubMed:7925268, ECO:0000269|PubMed:9009272, ECO:0000305|PubMed:8298642}.	MISCELLANEOUS: The alpha subunit binds strychnine. {ECO:0000269|PubMed:2155780}.	acrosome reaction [GO:0007340]; adult walking behavior [GO:0007628]; cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; inhibitory postsynaptic potential [GO:0060080]; monoatomic ion transport [GO:0006811]; muscle contraction [GO:0006936]; negative regulation of transmission of nerve impulse [GO:0051970]; neuromuscular process controlling posture [GO:0050884]; neuronal action potential [GO:0019228]; neuropeptide signaling pathway [GO:0007218]; positive regulation of acrosome reaction [GO:2000344]; regulation of membrane potential [GO:0042391]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; response to alcohol [GO:0097305]; response to amino acid [GO:0043200]; righting reflex [GO:0060013]; startle response [GO:0001964]; synaptic transmission, glycinergic [GO:0060012]; visual perception [GO:0007601]	chloride channel complex [GO:0034707]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; glycinergic synapse [GO:0098690]; inhibitory synapse [GO:0060077]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; taurine binding [GO:0030977]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; zinc ion binding [GO:0008270]	chloride channel complex [GO:0034707]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; glycinergic synapse [GO:0098690]; inhibitory synapse [GO:0060077]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; taurine binding [GO:0030977]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; zinc ion binding [GO:0008270]; acrosome reaction [GO:0007340]; adult walking behavior [GO:0007628]; cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; inhibitory postsynaptic potential [GO:0060080]; monoatomic ion transport [GO:0006811]; muscle contraction [GO:0006936]; negative regulation of transmission of nerve impulse [GO:0051970]; neuromuscular process controlling posture [GO:0050884]; neuronal action potential [GO:0019228]; neuropeptide signaling pathway [GO:0007218]; positive regulation of acrosome reaction [GO:2000344]; regulation of membrane potential [GO:0042391]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; response to alcohol [GO:0097305]; response to amino acid [GO:0043200]; righting reflex [GO:0060013]; startle response [GO:0001964]; synaptic transmission, glycinergic [GO:0060012]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q64018}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q64018}. Synapse {ECO:0000250|UniProtKB:Q64018}. Perikaryon {ECO:0000250|UniProtKB:Q64018}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q64018}. Cell membrane {ECO:0000269|PubMed:14551753, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:2155780, ECO:0000269|PubMed:22715885, ECO:0000269|PubMed:22973015, ECO:0000269|PubMed:24108130, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:25730860, ECO:0000269|PubMed:25973519, ECO:0000269|PubMed:7920629, ECO:0000269|PubMed:7925268, ECO:0000269|PubMed:9009272}; Multi-pass membrane protein {ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25730860, ECO:0000305|PubMed:2155780}.
P23416	reviewed	GLRA2_HUMAN	Glycine receptor subunit alpha-2	GLRA2	Homo sapiens (Human)	452	FUNCTION: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488, PubMed:26370147, PubMed:34473954). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in synaptic plasticity (By similarity). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467). {ECO:0000250|UniProtKB:Q7TNC8, ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:2155780, ECO:0000269|PubMed:23895467, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:34473954}.	MISCELLANEOUS: The alpha subunit binds strychnine. {ECO:0000269|PubMed:2155780}.	cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218]; response to amino acid [GO:0043200]	chloride channel complex [GO:0034707]; glycinergic synapse [GO:0098690]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; glycine-gated chloride ion channel activity [GO:0022852]; metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	chloride channel complex [GO:0034707]; glycinergic synapse [GO:0098690]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; glycine-gated chloride ion channel activity [GO:0022852]; metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218]; response to amino acid [GO:0043200]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q7TNC8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Synapse {ECO:0000250|UniProtKB:Q7TNC8}. Cell membrane {ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:2155780, ECO:0000269|PubMed:23895467, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:26370147}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cell projection {ECO:0000250|UniProtKB:Q7TNC8}.
P23434	reviewed	GCSH_HUMAN	Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)	GCSH	Homo sapiens (Human)	173	FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). {ECO:0000269|PubMed:1671321}.		glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]; protein lipoylation [GO:0009249]	cytoplasm [GO:0005737]; glycine cleavage complex [GO:0005960]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	aminomethyltransferase activity [GO:0004047]	cytoplasm [GO:0005737]; glycine cleavage complex [GO:0005960]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; aminomethyltransferase activity [GO:0004047]; glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]; protein lipoylation [GO:0009249]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P20821}.
P23435	reviewed	CBLN1_HUMAN	Cerebellin-1 (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin]	CBLN1	Homo sapiens (Human)	193	FUNCTION: Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (PubMed:27418511). Essential for long-term maintenance but not establishment of excitatory synapses (By similarity). Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells (By similarity). {ECO:0000250|UniProtKB:Q9R171, ECO:0000269|PubMed:27418511}.; FUNCTION: The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity). {ECO:0000250|UniProtKB:P63182}.		cerebellar granule cell differentiation [GO:0021707]; chemical synaptic transmission [GO:0007268]; establishment of localization in cell [GO:0051649]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; maintenance of synapse structure [GO:0099558]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of inhibitory synapse assembly [GO:1905703]; nervous system development [GO:0007399]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; protein secretion [GO:0009306]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic membrane [GO:0045211]; synaptic cleft [GO:0043083]	identical protein binding [GO:0042802]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic membrane [GO:0045211]; synaptic cleft [GO:0043083]; identical protein binding [GO:0042802]; cerebellar granule cell differentiation [GO:0021707]; chemical synaptic transmission [GO:0007268]; establishment of localization in cell [GO:0051649]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; maintenance of synapse structure [GO:0099558]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of inhibitory synapse assembly [GO:1905703]; nervous system development [GO:0007399]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; protein secretion [GO:0009306]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9R171}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9R171}.
P23443	reviewed	KS6B1_HUMAN	Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA)	RPS6KB1 STK14A	Homo sapiens (Human)	525	FUNCTION: Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:23429703, PubMed:28178239, PubMed:22017876). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:23429703, PubMed:28178239, PubMed:22017876). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}.		apoptotic process [GO:0006915]; behavioral fear response [GO:0001662]; cell migration [GO:0016477]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; cellular response to nutrient [GO:0031670]; cellular response to type II interferon [GO:0071346]; G1/S transition of mitotic cell cycle [GO:0000082]; germ cell development [GO:0007281]; long-chain fatty acid import into cell [GO:0044539]; long-term memory [GO:0007616]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of insulin receptor signaling pathway [GO:0046627]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of glucose import [GO:0046324]; response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to glucose [GO:0009749]; response to leucine [GO:0043201]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; response to testosterone [GO:0033574]; response to toxic substance [GO:0009636]; response to tumor necrosis factor [GO:0034612]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; skeletal muscle atrophy [GO:0014732]; skeletal muscle contraction [GO:0003009]; TOR signaling [GO:0031929]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; peptide binding [GO:0042277]; protein kinase activity [GO:0004672]; protein phosphatase 2A binding [GO:0051721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ribosomal protein S6 kinase activity [GO:0004711]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; peptide binding [GO:0042277]; protein kinase activity [GO:0004672]; protein phosphatase 2A binding [GO:0051721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ribosomal protein S6 kinase activity [GO:0004711]; apoptotic process [GO:0006915]; behavioral fear response [GO:0001662]; cell migration [GO:0016477]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; cellular response to nutrient [GO:0031670]; cellular response to type II interferon [GO:0071346]; G1/S transition of mitotic cell cycle [GO:0000082]; germ cell development [GO:0007281]; long-chain fatty acid import into cell [GO:0044539]; long-term memory [GO:0007616]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of insulin receptor signaling pathway [GO:0046627]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of glucose import [GO:0046324]; response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to glucose [GO:0009749]; response to leucine [GO:0043201]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; response to testosterone [GO:0033574]; response to toxic substance [GO:0009636]; response to tumor necrosis factor [GO:0034612]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; skeletal muscle atrophy [GO:0014732]; skeletal muscle contraction [GO:0003009]; TOR signaling [GO:0031929]	SUBCELLULAR LOCATION: Synapse, synaptosome {ECO:0000250}. Mitochondrion outer membrane. Mitochondrion. Note=Colocalizes with URI1 at mitochondrion.; SUBCELLULAR LOCATION: [Isoform Alpha I]: Nucleus. Cytoplasm.; SUBCELLULAR LOCATION: [Isoform Alpha II]: Cytoplasm.
P23458	reviewed	JAK1_HUMAN	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)	JAK1 JAK1A JAK1B	Homo sapiens (Human)	1154	FUNCTION: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:8232552, PubMed:7615558, PubMed:28111307, PubMed:32750333, PubMed:16239216). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:8232552, PubMed:7615558, PubMed:28111307, PubMed:32750333, PubMed:16239216). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:8232552, PubMed:16239216, PubMed:32750333). {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16239216, ECO:0000269|PubMed:28111307, ECO:0000269|PubMed:32750333, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:8232552}.		cell differentiation [GO:0030154]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-6-mediated signaling pathway [GO:0070102]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular signal transduction [GO:0035556]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of sprouting angiogenesis [GO:1903672]; protein localization to cell-cell junction [GO:0150105]; protein phosphorylation [GO:0006468]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to antibiotic [GO:0046677]; T-helper 17 cell lineage commitment [GO:0072540]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; CCR5 chemokine receptor binding [GO:0031730]; growth hormone receptor binding [GO:0005131]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; CCR5 chemokine receptor binding [GO:0031730]; growth hormone receptor binding [GO:0005131]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; ubiquitin protein ligase binding [GO:0031625]; cell differentiation [GO:0030154]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-6-mediated signaling pathway [GO:0070102]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular signal transduction [GO:0035556]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of sprouting angiogenesis [GO:1903672]; protein localization to cell-cell junction [GO:0150105]; protein phosphorylation [GO:0006468]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to antibiotic [GO:0046677]; T-helper 17 cell lineage commitment [GO:0072540]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196]	SUBCELLULAR LOCATION: Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
P23467	reviewed	PTPRB_HUMAN	Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)	PTPRB PTPB	Homo sapiens (Human)	1997	FUNCTION: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity). {ECO:0000250, ECO:0000269|PubMed:19116766, ECO:0000269|PubMed:19136612}.		angiogenesis [GO:0001525]; dephosphorylation [GO:0016311]; glial cell migration [GO:0008347]; phosphate-containing compound metabolic process [GO:0006796]; protein dephosphorylation [GO:0006470]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	cadherin binding [GO:0045296]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; cadherin binding [GO:0045296]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; angiogenesis [GO:0001525]; dephosphorylation [GO:0016311]; glial cell migration [GO:0008347]; phosphate-containing compound metabolic process [GO:0006796]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
P23468	reviewed	PTPRD_HUMAN	Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48)	PTPRD	Homo sapiens (Human)	1912	FUNCTION: Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. {ECO:0000250|UniProtKB:Q64487}.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; neuron differentiation [GO:0030182]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of synapse assembly [GO:0051965]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein dephosphorylation [GO:0006470]; regulation of immune response [GO:0050776]; regulation of postsynaptic density assembly [GO:0099151]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling by trans-synaptic complex [GO:0099545]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]	extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]	cell adhesion molecule binding [GO:0050839]; protein tyrosine phosphatase activity [GO:0004725]; signaling receptor binding [GO:0005102]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; cell adhesion molecule binding [GO:0050839]; protein tyrosine phosphatase activity [GO:0004725]; signaling receptor binding [GO:0005102]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; neuron differentiation [GO:0030182]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of synapse assembly [GO:0051965]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein dephosphorylation [GO:0006470]; regulation of immune response [GO:0050776]; regulation of postsynaptic density assembly [GO:0099151]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling by trans-synaptic complex [GO:0099545]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P23469	reviewed	PTPRE_HUMAN	Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)	PTPRE	Homo sapiens (Human)	700	FUNCTION: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). {ECO:0000250}.; FUNCTION: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity). {ECO:0000250}.; FUNCTION: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation at Met-86 of isoform 1. {ECO:0000305}.	negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
P23470	reviewed	PTPRG_HUMAN	Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48)	PTPRG PTPG	Homo sapiens (Human)	1445	FUNCTION: Possesses tyrosine phosphatase activity. {ECO:0000269|PubMed:19167335}.		dephosphorylation [GO:0016311]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of neuron projection development [GO:0010977]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; dephosphorylation [GO:0016311]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of neuron projection development [GO:0010977]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
P23471	reviewed	PTPRZ_HUMAN	Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2)	PTPRZ1 HTPZP2 PTPRZ PTPRZ2 PTPZ	Homo sapiens (Human)	2315	FUNCTION: Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). {ECO:0000250}.		axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; hematopoietic progenitor cell differentiation [GO:0002244]; learning or memory [GO:0007611]; negative regulation of neuron apoptotic process [GO:0043524]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of oligodendrocyte differentiation [GO:0048714]; protein dephosphorylation [GO:0006470]; regulation of myelination [GO:0031641]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]	extracellular region [GO:0005576]; perineuronal net [GO:0072534]; plasma membrane [GO:0005886]; synapse [GO:0045202]	integrin binding [GO:0005178]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	extracellular region [GO:0005576]; perineuronal net [GO:0072534]; plasma membrane [GO:0005886]; synapse [GO:0045202]; integrin binding [GO:0005178]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; hematopoietic progenitor cell differentiation [GO:0002244]; learning or memory [GO:0007611]; negative regulation of neuron apoptotic process [GO:0043524]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of oligodendrocyte differentiation [GO:0048714]; protein dephosphorylation [GO:0006470]; regulation of myelination [GO:0031641]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted {ECO:0000250}. Note=A secreted form is apparently generated by shedding of the extracellular domain. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
P23490	reviewed	LORI_HUMAN	Loricrin	LORICRIN LOR LRN	Homo sapiens (Human)	312	FUNCTION: Major keratinocyte cell envelope protein.		keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm.
P23497	reviewed	SP100_HUMAN	Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)	SP100	Homo sapiens (Human)	879	FUNCTION: Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}.	MISCELLANEOUS: The major isoform Sp100-A, has a calculated molecular weight of 54 kDa, but exhibits aberrant electrophoretic mobilities, with an apparent molecular weight of 100 kDa.; MISCELLANEOUS: [Isoform Sp100-A]: Major isoform. {ECO:0000305}.	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; maintenance of protein location [GO:0045185]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Fas signaling pathway [GO:1902044]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cytokine [GO:0034097]; response to retinoic acid [GO:0032526]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; retinoic acid receptor signaling pathway [GO:0048384]; telomere maintenance [GO:0000723]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear periphery [GO:0034399]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear periphery [GO:0034399]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; maintenance of protein location [GO:0045185]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Fas signaling pathway [GO:1902044]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cytokine [GO:0034097]; response to retinoic acid [GO:0032526]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; retinoic acid receptor signaling pathway [GO:0048384]; telomere maintenance [GO:0000723]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309}. Nucleus, PML body {ECO:0000269|PubMed:27211601}. Nucleus, nuclear body {ECO:0000269|PubMed:17245429}. Cytoplasm {ECO:0000269|PubMed:17245429}. Note=Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon-dependent. Accumulates in the cytoplasm upon FAS activation. {ECO:0000269|PubMed:17245429}.; SUBCELLULAR LOCATION: [Isoform Sp100-C]: Nucleus {ECO:0000269|PubMed:11313457}. Note=Forms a reticulate or track-like nuclear pattern with denser concentrations at the nuclear lamina and surrounding the nucleoli, a pattern reminiscent of heterochromatin-rich regions according to PubMed:11313457.
P23508	reviewed	CRCM_HUMAN	Colorectal mutant cancer protein (Protein MCC)	MCC	Homo sapiens (Human)	829	FUNCTION: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}.		establishment of protein localization [GO:0045184]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; establishment of protein localization [GO:0045184]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane. Cell projection, lamellipodium. Nucleus {ECO:0000269|PubMed:24824780}. Cytoplasm {ECO:0000269|PubMed:24824780}. Note=Colocalizes with actin at the leading edge of polarized cells.
P23510	reviewed	TNFL4_HUMAN	Tumor necrosis factor ligand superfamily member 4 (Glycoprotein Gp34) (OX40 ligand) (OX40L) (TAX transcriptionally-activated glycoprotein 1) (CD antigen CD252)	TNFSF4 TXGP1	Homo sapiens (Human)	183	FUNCTION: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.		acute inflammatory response [GO:0002526]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to prostaglandin E stimulus [GO:0071380]; defense response to nematode [GO:0002215]; immune response [GO:0006955]; inflammatory response [GO:0006954]; memory T cell activation [GO:0035709]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of regulatory T cell differentiation [GO:0045590]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of type II interferon production [GO:0032689]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of B cell activation [GO:0050871]; positive regulation of CD4-positive, alpha-beta T cell costimulation [GO:1900281]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of immunoglobulin mediated immune response [GO:0002891]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-4-dependent isotype switching to IgE isotypes [GO:2000572]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of type 2 immune response [GO:0002830]; positive regulation of type II interferon production [GO:0032729]; regulation of adaptive immune response [GO:0002819]; regulation of inflammatory response [GO:0050727]; response to nitrogen dioxide [GO:0035713]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T-helper 2 cell activation [GO:0035712]	cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]	cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]; acute inflammatory response [GO:0002526]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to prostaglandin E stimulus [GO:0071380]; defense response to nematode [GO:0002215]; immune response [GO:0006955]; inflammatory response [GO:0006954]; memory T cell activation [GO:0035709]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of regulatory T cell differentiation [GO:0045590]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of type II interferon production [GO:0032689]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of B cell activation [GO:0050871]; positive regulation of CD4-positive, alpha-beta T cell costimulation [GO:1900281]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of immunoglobulin mediated immune response [GO:0002891]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-4-dependent isotype switching to IgE isotypes [GO:2000572]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of type 2 immune response [GO:0002830]; positive regulation of type II interferon production [GO:0032729]; regulation of adaptive immune response [GO:0002819]; regulation of inflammatory response [GO:0050727]; response to nitrogen dioxide [GO:0035713]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T-helper 2 cell activation [GO:0035712]	SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
P23511	reviewed	NFYA_HUMAN	Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA)	NFYA	Homo sapiens (Human)	347	FUNCTION: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1. {ECO:0000269|PubMed:12741956}.		positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of histone acetylation [GO:0035065]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; transcription by RNA polymerase II [GO:0006366]	CCAAT-binding factor complex [GO:0016602]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	CCAAT-binding factor complex [GO:0016602]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of histone acetylation [GO:0035065]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
P23515	reviewed	OMGP_HUMAN	Oligodendrocyte-myelin glycoprotein	OMG OMGP	Homo sapiens (Human)	440	FUNCTION: Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.		cell adhesion [GO:0007155]; neuron projection regeneration [GO:0031102]	plasma membrane [GO:0005886]; side of membrane [GO:0098552]		plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell adhesion [GO:0007155]; neuron projection regeneration [GO:0031102]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
P23526	reviewed	SAHH_HUMAN	Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase)	AHCY SAHH	Homo sapiens (Human)	432	FUNCTION: Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity). {ECO:0000250|UniProtKB:P50247, ECO:0000269|PubMed:10933798}.		one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; nucleus [GO:0005634]	adenosylhomocysteinase activity [GO:0004013]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; nucleus [GO:0005634]; adenosylhomocysteinase activity [GO:0004013]; one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus {ECO:0000269|PubMed:28647132}. Endoplasmic reticulum {ECO:0000269|PubMed:28647132}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
P23527	reviewed	H2B1O_HUMAN	Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n)	H2BC17 H2BFH H2BFN HIST1H2BO	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	MISCELLANEOUS: The mouse orthologous protein seems not to exist.	nucleosome assembly [GO:0006334]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P23528	reviewed	COF1_HUMAN	Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)	CFL1 CFL	Homo sapiens (Human)	166	FUNCTION: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). {ECO:0000250|UniProtKB:P18760, ECO:0000269|PubMed:11812157, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:23633677}.		actin cytoskeleton organization [GO:0030036]; actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; actin filament severing [GO:0051014]; cytoskeleton organization [GO:0007010]; establishment of spindle localization [GO:0051293]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; positive regulation by host of viral process [GO:0044794]; positive regulation of embryonic development [GO:0040019]; regulation of cell morphogenesis [GO:0022604]; regulation of dendritic spine morphogenesis [GO:0061001]; response to virus [GO:0009615]; Rho protein signal transduction [GO:0007266]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; vesicle [GO:0031982]	actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; actin cytoskeleton organization [GO:0030036]; actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; actin filament severing [GO:0051014]; cytoskeleton organization [GO:0007010]; establishment of spindle localization [GO:0051293]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; positive regulation by host of viral process [GO:0044794]; positive regulation of embryonic development [GO:0040019]; regulation of cell morphogenesis [GO:0022604]; regulation of dendritic spine morphogenesis [GO:0061001]; response to virus [GO:0009615]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P18760}. Cell projection, growth cone {ECO:0000250|UniProtKB:P18760}. Cell projection, axon {ECO:0000250|UniProtKB:P18760}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
P23560	reviewed	BDNF_HUMAN	Brain-derived neurotrophic factor (BDNF) (Abrineurin) [Cleaved into: BDNF precursor form (ProBDNF)]	BDNF	Homo sapiens (Human)	247	FUNCTION: Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:12553913, ECO:0000269|PubMed:29909994}.; FUNCTION: [BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity). {ECO:0000250|UniProtKB:P21237, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:29909994}.		axon guidance [GO:0007411]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; collateral sprouting [GO:0048668]; memory [GO:0007613]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neuron apoptotic process [GO:0043524]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; peripheral nervous system development [GO:0007422]; positive regulation of brain-derived neurotrophic factor receptor signaling pathway [GO:0031550]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of receptor binding [GO:1900122]; positive regulation of synapse assembly [GO:0051965]; regulation of neuron differentiation [GO:0045664]; regulation of protein localization to cell surface [GO:2000008]; synapse assembly [GO:0007416]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; synaptic vesicle [GO:0008021]	growth factor activity [GO:0008083]; nerve growth factor receptor binding [GO:0005163]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; synaptic vesicle [GO:0008021]; growth factor activity [GO:0008083]; nerve growth factor receptor binding [GO:0005163]; axon guidance [GO:0007411]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; collateral sprouting [GO:0048668]; memory [GO:0007613]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neuron apoptotic process [GO:0043524]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; peripheral nervous system development [GO:0007422]; positive regulation of brain-derived neurotrophic factor receptor signaling pathway [GO:0031550]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of receptor binding [GO:1900122]; positive regulation of synapse assembly [GO:0051965]; regulation of neuron differentiation [GO:0045664]; regulation of protein localization to cell surface [GO:2000008]; synapse assembly [GO:0007416]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:19467646, ECO:0000269|PubMed:8527932}.; SUBCELLULAR LOCATION: [BDNF precursor form]: Secreted {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:19467646}. Note=A proportion of BDNF is secreted as immature precursor (proBDNF). {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:19467646}.
P23582	reviewed	ANFC_HUMAN	C-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53]	NPPC CNP2	Homo sapiens (Human)	126	FUNCTION: [CNP-22]: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic (PubMed:1672777). Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:1672777, PubMed:21098034). Binds the clearance receptor NPR3 (PubMed:11533490). {ECO:0000250|UniProtKB:Q61839, ECO:0000269|PubMed:11533490, ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:21098034}.		angiogenesis [GO:0001525]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; c-di-GMP signaling [GO:0061939]; cellular response to glycoprotein [GO:1904588]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; chromosome organization [GO:0051276]; cumulus cell differentiation [GO:0001549]; gastric emptying [GO:0035483]; growth plate cartilage chondrocyte differentiation [GO:0003418]; growth plate cartilage chondrocyte proliferation [GO:0003419]; intracellular calcium ion homeostasis [GO:0006874]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; multicellular organismal locomotion [GO:0071965]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oocyte maturation [GO:1900194]; ossification [GO:0001503]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of osteoblast differentiation [GO:0045669]; post-embryonic development [GO:0009791]; protein folding [GO:0006457]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of multicellular organism growth [GO:0040014]; regulation of smooth muscle cell proliferation [GO:0048660]; response to axon injury [GO:0048678]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; response to oxygen-glucose deprivation [GO:0090649]; response to xenobiotic stimulus [GO:0009410]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]	hormone activity [GO:0005179]; hormone receptor binding [GO:0051427]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; hormone activity [GO:0005179]; hormone receptor binding [GO:0051427]; signaling receptor binding [GO:0005102]; angiogenesis [GO:0001525]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; c-di-GMP signaling [GO:0061939]; cellular response to glycoprotein [GO:1904588]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; chromosome organization [GO:0051276]; cumulus cell differentiation [GO:0001549]; gastric emptying [GO:0035483]; growth plate cartilage chondrocyte differentiation [GO:0003418]; growth plate cartilage chondrocyte proliferation [GO:0003419]; intracellular calcium ion homeostasis [GO:0006874]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; multicellular organismal locomotion [GO:0071965]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oocyte maturation [GO:1900194]; ossification [GO:0001503]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of osteoblast differentiation [GO:0045669]; post-embryonic development [GO:0009791]; protein folding [GO:0006457]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of multicellular organism growth [GO:0040014]; regulation of smooth muscle cell proliferation [GO:0048660]; response to axon injury [GO:0048678]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; response to oxygen-glucose deprivation [GO:0090649]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Secreted.
P23588	reviewed	IF4B_HUMAN	Eukaryotic translation initiation factor 4B (eIF-4B)	EIF4B	Homo sapiens (Human)	611	FUNCTION: Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.		regulation of translational initiation [GO:0006446]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; regulation of translational initiation [GO:0006446]	
P23610	reviewed	HAP40_HUMAN	40-kDa huntingtin-associated protein (HAP40) (CpG island protein) (Factor VIII intron 22 protein)	F8A1; F8A2; F8A3	Homo sapiens (Human)	371	FUNCTION: RAB5A effector molecule that is involved in vesicular trafficking of early endosomes (PubMed:16476778). Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed:16476778). {ECO:0000269|PubMed:16476778}.		negative regulation of proteasomal protein catabolic process [GO:1901799]; vesicle cytoskeletal trafficking [GO:0099518]	early endosome [GO:0005769]; nuclear body [GO:0016604]; nucleus [GO:0005634]		early endosome [GO:0005769]; nuclear body [GO:0016604]; nucleus [GO:0005634]; negative regulation of proteasomal protein catabolic process [GO:1901799]; vesicle cytoskeletal trafficking [GO:0099518]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16476778}. Nucleus {ECO:0000269|PubMed:16476778}. Early endosome {ECO:0000269|PubMed:16476778}. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q00558}. Note=Diffuse presence in the cytoplasm and accumulation in the nucleus (PubMed:16476778). In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (By similarity). Colocalized with HTT in endosomes (PubMed:16476778). In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (By similarity). {ECO:0000250|UniProtKB:Q00558, ECO:0000269|PubMed:16476778}.
P23634	reviewed	AT2B4_HUMAN	Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)	ATP2B4 ATP2B2 MXRA1	Homo sapiens (Human)	1241	FUNCTION: Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}.		calcium ion export [GO:1901660]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; cellular response to acetylcholine [GO:1905145]; cellular response to epinephrine stimulus [GO:0071872]; flagellated sperm motility [GO:0030317]; hippocampus development [GO:0021766]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0140199]; negative regulation of angiogenesis [GO:0016525]; negative regulation of arginine catabolic process [GO:1900082]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cellular response to vascular endothelial growth factor stimulus [GO:1902548]; negative regulation of citrulline biosynthetic process [GO:1903249]; negative regulation of gene expression [GO:0010629]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of nitric oxide mediated signal transduction [GO:0010751]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; negative regulation of the force of heart contraction [GO:0098736]; neural retina development [GO:0003407]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of cardiac conduction [GO:1903779]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hydrostatic pressure [GO:0051599]; spermatogenesis [GO:0007283]; transport across blood-brain barrier [GO:0150104]; urinary bladder smooth muscle contraction [GO:0014832]	basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; sperm flagellum [GO:0036126]; sperm principal piece [GO:0097228]; T-tubule [GO:0030315]; Z disc [GO:0030018]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; nitric-oxide synthase binding [GO:0050998]; nitric-oxide synthase inhibitor activity [GO:0036487]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein phosphatase 2B binding [GO:0030346]; scaffold protein binding [GO:0097110]; sodium channel regulator activity [GO:0017080]	basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; sperm flagellum [GO:0036126]; sperm principal piece [GO:0097228]; T-tubule [GO:0030315]; Z disc [GO:0030018]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; nitric-oxide synthase binding [GO:0050998]; nitric-oxide synthase inhibitor activity [GO:0036487]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein phosphatase 2B binding [GO:0030346]; scaffold protein binding [GO:0097110]; sodium channel regulator activity [GO:0017080]; calcium ion export [GO:1901660]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; cellular response to acetylcholine [GO:1905145]; cellular response to epinephrine stimulus [GO:0071872]; flagellated sperm motility [GO:0030317]; hippocampus development [GO:0021766]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0140199]; negative regulation of angiogenesis [GO:0016525]; negative regulation of arginine catabolic process [GO:1900082]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cellular response to vascular endothelial growth factor stimulus [GO:1902548]; negative regulation of citrulline biosynthetic process [GO:1903249]; negative regulation of gene expression [GO:0010629]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of nitric oxide mediated signal transduction [GO:0010751]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; negative regulation of the force of heart contraction [GO:0098736]; neural retina development [GO:0003407]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of cardiac conduction [GO:1903779]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hydrostatic pressure [GO:0051599]; spermatogenesis [GO:0007283]; transport across blood-brain barrier [GO:0150104]; urinary bladder smooth muscle contraction [GO:0014832]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2137451}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q6Q477}; Multi-pass membrane protein {ECO:0000255}.
P23677	reviewed	IP3KA_HUMAN	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A)	ITPKA	Homo sapiens (Human)	461	FUNCTION: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:15350214, ECO:0000269|PubMed:1847047}.		actin cytoskeleton organization [GO:0030036]; cellular response to calcium ion [GO:0071277]; dendritic spine maintenance [GO:0097062]; inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; modification of postsynaptic actin cytoskeleton [GO:0098885]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of dendritic spine morphogenesis [GO:0061003]; regulation of synaptic plasticity [GO:0048167]; response to calcium ion [GO:0051592]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic actin cytoskeleton [GO:0098871]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic actin cytoskeleton [GO:0098871]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; cellular response to calcium ion [GO:0071277]; dendritic spine maintenance [GO:0097062]; inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; modification of postsynaptic actin cytoskeleton [GO:0098885]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of dendritic spine morphogenesis [GO:0061003]; regulation of synaptic plasticity [GO:0048167]; response to calcium ion [GO:0051592]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12747803}.
P23743	reviewed	DGKA_HUMAN	Diacylglycerol kinase alpha (DAG kinase alpha) (EC 2.7.1.107) (80 kDa diacylglycerol kinase) (Diglyceride kinase alpha) (DGK-alpha)	DGKA DAGK DAGK1	Homo sapiens (Human)	735	FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:2175712, PubMed:15544348). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:2175712, PubMed:15544348). Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group (PubMed:15544348). Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol (PubMed:22627129). {ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:2175712, ECO:0000269|PubMed:22627129, ECO:0000305}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]	cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; kinase activity [GO:0016301]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; kinase activity [GO:0016301]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543]; diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:2175712}.
P23759	reviewed	PAX7_HUMAN	Paired box protein Pax-7 (HuP1)	PAX7 HUP1	Homo sapiens (Human)	505	FUNCTION: Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration. {ECO:0000269|PubMed:31092906}.		anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P47239}.
P23760	reviewed	PAX3_HUMAN	Paired box protein Pax-3 (HuP2)	PAX3 HUP2	Homo sapiens (Human)	479	FUNCTION: Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087). {ECO:0000269|PubMed:16951170, ECO:0000269|PubMed:21965087}.		anatomical structure development [GO:0048856]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure development [GO:0048856]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21965087}.
P23763	reviewed	VAMP1_HUMAN	Vesicle-associated membrane protein 1 (VAMP-1) (Synaptobrevin-1)	VAMP1 SYB1	Homo sapiens (Human)	118	FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane.		SNARE complex assembly [GO:0035493]; vesicle fusion [GO:0006906]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]; tertiary granule membrane [GO:0070821]	SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]; tertiary granule membrane [GO:0070821]; SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]; SNARE complex assembly [GO:0035493]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasmic vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion outer membrane; Single-pass type IV membrane protein {ECO:0000269|PubMed:9658161}.
P23769	reviewed	GATA2_HUMAN	Endothelial transcription factor GATA-2 (GATA-binding protein 2)	GATA2	Homo sapiens (Human)	480	FUNCTION: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.		brown fat cell differentiation [GO:0050873]; cell differentiation in hindbrain [GO:0021533]; cell fate commitment [GO:0045165]; cell fate determination [GO:0001709]; central nervous system neuron development [GO:0021954]; cochlea development [GO:0090102]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; definitive hemopoiesis [GO:0060216]; embryonic placenta development [GO:0001892]; eosinophil fate commitment [GO:0035854]; fat cell differentiation [GO:0045444]; GABAergic neuron differentiation [GO:0097154]; glandular epithelial cell maturation [GO:0002071]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; homeostasis of number of cells within a tissue [GO:0048873]; inner ear morphogenesis [GO:0042472]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of gene expression [GO:0010629]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast proliferation [GO:0007405]; neuron maturation [GO:0042551]; neuron migration [GO:0001764]; phagocytosis [GO:0006909]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of forebrain neuron differentiation [GO:2000977]; regulation of histone acetylation [GO:0035065]; regulation of primitive erythrocyte differentiation [GO:0010725]; response to lipid [GO:0033993]; semicircular canal development [GO:0060872]; somatic stem cell population maintenance [GO:0035019]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; transcription by RNA polymerase II [GO:0006366]; urogenital system development [GO:0001655]; vascular wound healing [GO:0061042]; ventral spinal cord interneuron differentiation [GO:0021514]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]; brown fat cell differentiation [GO:0050873]; cell differentiation in hindbrain [GO:0021533]; cell fate commitment [GO:0045165]; cell fate determination [GO:0001709]; central nervous system neuron development [GO:0021954]; cochlea development [GO:0090102]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; definitive hemopoiesis [GO:0060216]; embryonic placenta development [GO:0001892]; eosinophil fate commitment [GO:0035854]; fat cell differentiation [GO:0045444]; GABAergic neuron differentiation [GO:0097154]; glandular epithelial cell maturation [GO:0002071]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; homeostasis of number of cells within a tissue [GO:0048873]; inner ear morphogenesis [GO:0042472]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of gene expression [GO:0010629]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast proliferation [GO:0007405]; neuron maturation [GO:0042551]; neuron migration [GO:0001764]; phagocytosis [GO:0006909]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of forebrain neuron differentiation [GO:2000977]; regulation of histone acetylation [GO:0035065]; regulation of primitive erythrocyte differentiation [GO:0010725]; response to lipid [GO:0033993]; semicircular canal development [GO:0060872]; somatic stem cell population maintenance [GO:0035019]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; transcription by RNA polymerase II [GO:0006366]; urogenital system development [GO:0001655]; vascular wound healing [GO:0061042]; ventral spinal cord interneuron differentiation [GO:0021514]	SUBCELLULAR LOCATION: Nucleus.
P23771	reviewed	GATA3_HUMAN	Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3)	GATA3	Homo sapiens (Human)	443	FUNCTION: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. {ECO:0000250|UniProtKB:P23772, ECO:0000269|PubMed:23824597}.		anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; aortic valve morphogenesis [GO:0003180]; axon guidance [GO:0007411]; canonical Wnt signaling pathway involved in metanephric kidney development [GO:0061290]; cardiac right ventricle morphogenesis [GO:0003215]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cell fate determination [GO:0001709]; cell maturation [GO:0048469]; cellular response to BMP stimulus [GO:0071773]; cellular response to interferon-alpha [GO:0035457]; cellular response to interleukin-4 [GO:0071353]; cellular response to tumor necrosis factor [GO:0071356]; chromatin remodeling [GO:0006338]; defense response [GO:0006952]; developmental growth [GO:0048589]; ear development [GO:0043583]; embryonic hemopoiesis [GO:0035162]; embryonic organ development [GO:0048568]; erythrocyte differentiation [GO:0030218]; humoral immune response [GO:0006959]; immune system development [GO:0002520]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; lymphocyte migration [GO:0072676]; macrophage differentiation [GO:0030225]; male gonad development [GO:0008584]; mast cell differentiation [GO:0060374]; mesenchymal to epithelial transition [GO:0060231]; mesonephros development [GO:0001823]; natural killer cell activation [GO:0030101]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell motility [GO:2000146]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell proliferation involved in mesonephros development [GO:2000607]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [GO:2000703]; negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation [GO:2000734]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; nephric duct formation [GO:0072179]; nephric duct morphogenesis [GO:0072178]; neuron migration [GO:0001764]; norepinephrine biosynthetic process [GO:0042421]; otic vesicle development [GO:0071599]; parathyroid gland development [GO:0060017]; parathyroid hormone secretion [GO:0035898]; pharyngeal system development [GO:0060037]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of signal transduction [GO:0009967]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of ureteric bud formation [GO:0072107]; post-embryonic development [GO:0009791]; pro-T cell differentiation [GO:0002572]; regulation of cellular response to X-ray [GO:2000683]; regulation of cytokine production [GO:0001817]; regulation of epithelial cell differentiation [GO:0030856]; regulation of establishment of cell polarity [GO:2000114]; regulation of nephron tubule epithelial cell differentiation [GO:0072182]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuron projection development [GO:0010975]; regulation of T-helper cell differentiation [GO:0045622]; response to estrogen [GO:0043627]; response to virus [GO:0009615]; signal transduction [GO:0007165]; sympathetic nervous system development [GO:0048485]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]; T-helper 2 cell differentiation [GO:0045064]; thymic T cell selection [GO:0045061]; thymus development [GO:0048538]; TOR signaling [GO:0031929]; transcription by RNA polymerase II [GO:0006366]; ureter maturation [GO:0035799]; ureter morphogenesis [GO:0072197]; ureteric bud formation [GO:0060676]; uterus development [GO:0060065]; ventricular septum development [GO:0003281]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; HMG box domain binding [GO:0071837]; identical protein binding [GO:0042802]; interleukin-2 receptor binding [GO:0005134]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; HMG box domain binding [GO:0071837]; identical protein binding [GO:0042802]; interleukin-2 receptor binding [GO:0005134]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]; anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; aortic valve morphogenesis [GO:0003180]; axon guidance [GO:0007411]; canonical Wnt signaling pathway involved in metanephric kidney development [GO:0061290]; cardiac right ventricle morphogenesis [GO:0003215]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cell fate determination [GO:0001709]; cell maturation [GO:0048469]; cellular response to BMP stimulus [GO:0071773]; cellular response to interferon-alpha [GO:0035457]; cellular response to interleukin-4 [GO:0071353]; cellular response to tumor necrosis factor [GO:0071356]; chromatin remodeling [GO:0006338]; defense response [GO:0006952]; developmental growth [GO:0048589]; ear development [GO:0043583]; embryonic hemopoiesis [GO:0035162]; embryonic organ development [GO:0048568]; erythrocyte differentiation [GO:0030218]; humoral immune response [GO:0006959]; immune system development [GO:0002520]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; lymphocyte migration [GO:0072676]; macrophage differentiation [GO:0030225]; male gonad development [GO:0008584]; mast cell differentiation [GO:0060374]; mesenchymal to epithelial transition [GO:0060231]; mesonephros development [GO:0001823]; natural killer cell activation [GO:0030101]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell motility [GO:2000146]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell proliferation involved in mesonephros development [GO:2000607]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [GO:2000703]; negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation [GO:2000734]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; nephric duct formation [GO:0072179]; nephric duct morphogenesis [GO:0072178]; neuron migration [GO:0001764]; norepinephrine biosynthetic process [GO:0042421]; otic vesicle development [GO:0071599]; parathyroid gland development [GO:0060017]; parathyroid hormone secretion [GO:0035898]; pharyngeal system development [GO:0060037]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of signal transduction [GO:0009967]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of ureteric bud formation [GO:0072107]; post-embryonic development [GO:0009791]; pro-T cell differentiation [GO:0002572]; regulation of cellular response to X-ray [GO:2000683]; regulation of cytokine production [GO:0001817]; regulation of epithelial cell differentiation [GO:0030856]; regulation of establishment of cell polarity [GO:2000114]; regulation of nephron tubule epithelial cell differentiation [GO:0072182]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuron projection development [GO:0010975]; regulation of T-helper cell differentiation [GO:0045622]; response to estrogen [GO:0043627]; response to virus [GO:0009615]; signal transduction [GO:0007165]; sympathetic nervous system development [GO:0048485]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]; T-helper 2 cell differentiation [GO:0045064]; thymic T cell selection [GO:0045061]; thymus development [GO:0048538]; TOR signaling [GO:0031929]; transcription by RNA polymerase II [GO:0006366]; ureter maturation [GO:0035799]; ureter morphogenesis [GO:0072197]; ureteric bud formation [GO:0060676]; uterus development [GO:0060065]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Nucleus.
P23786	reviewed	CPT2_HUMAN	Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II)	CPT2 CPT1	Homo sapiens (Human)	658	FUNCTION: Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056). {ECO:0000269|PubMed:20538056, ECO:0000269|PubMed:24780397}.		carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; fatty acid beta-oxidation [GO:0006635]; in utero embryonic development [GO:0001701]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of cold-induced thermogenesis [GO:0120162]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	acyltransferase activity [GO:0016746]; carnitine O-octanoyltransferase activity [GO:0008458]; carnitine O-palmitoyltransferase activity [GO:0004095]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; acyltransferase activity [GO:0016746]; carnitine O-octanoyltransferase activity [GO:0008458]; carnitine O-palmitoyltransferase activity [GO:0004095]; carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; fatty acid beta-oxidation [GO:0006635]; in utero embryonic development [GO:0001701]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of cold-induced thermogenesis [GO:0120162]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
P23919	reviewed	KTHY_HUMAN	Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)	DTYMK CDC8 TMPK TYMK	Homo sapiens (Human)	212	FUNCTION: Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+). {ECO:0000269|PubMed:12614151, ECO:0000269|PubMed:2017365, ECO:0000269|PubMed:34918187, ECO:0000269|PubMed:8024690, ECO:0000305|PubMed:18469}.		cellular response to growth factor stimulus [GO:0071363]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227]; myoblast differentiation [GO:0045445]; phosphorylation [GO:0016310]; response to cadmium ion [GO:0046686]; response to estrogen [GO:0043627]; thymidine biosynthetic process [GO:0046105]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550]; thymidylate kinase activity [GO:0004798]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550]; thymidylate kinase activity [GO:0004798]; cellular response to growth factor stimulus [GO:0071363]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227]; myoblast differentiation [GO:0045445]; phosphorylation [GO:0016310]; response to cadmium ion [GO:0046686]; response to estrogen [GO:0043627]; thymidine biosynthetic process [GO:0046105]	
P23921	reviewed	RIR1_HUMAN	Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)	RRM1 RR1	Homo sapiens (Human)	792	FUNCTION: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	MISCELLANEOUS: Two distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic site, located on M1, is formed only in the presence of the second subunit M2.; MISCELLANEOUS: The level of the enzyme activity is closely correlated with the growth rate of a cell and appears to vary with the cell cycle.	2'-deoxyribonucleotide biosynthetic process [GO:0009265]; cell proliferation in forebrain [GO:0021846]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; male gonad development [GO:0008584]; mitochondrial DNA replication [GO:0006264]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein heterotetramerization [GO:0051290]; pyrimidine nucleobase metabolic process [GO:0006206]; response to ionizing radiation [GO:0010212]; retina development in camera-type eye [GO:0060041]; ribonucleoside diphosphate metabolic process [GO:0009185]	cell projection [GO:0042995]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; ribonucleoside-diphosphate reductase complex [GO:0005971]	ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; ribonucleoside-diphosphate reductase activity [GO:0061731]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]	cell projection [GO:0042995]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; ribonucleoside-diphosphate reductase complex [GO:0005971]; ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; ribonucleoside-diphosphate reductase activity [GO:0061731]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]; 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; cell proliferation in forebrain [GO:0021846]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; male gonad development [GO:0008584]; mitochondrial DNA replication [GO:0006264]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein heterotetramerization [GO:0051290]; pyrimidine nucleobase metabolic process [GO:0006206]; response to ionizing radiation [GO:0010212]; retina development in camera-type eye [GO:0060041]; ribonucleoside diphosphate metabolic process [GO:0009185]	SUBCELLULAR LOCATION: Cytoplasm.
P23942	reviewed	PRPH2_HUMAN	Peripherin-2 (Retinal degeneration slow protein) (Tetraspanin-22) (Tspan-22)	PRPH2 PRPH RDS TSPAN22	Homo sapiens (Human)	346	FUNCTION: Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). {ECO:0000250|UniProtKB:P15499}.		cell adhesion [GO:0007155]; detection of light stimulus involved in visual perception [GO:0050908]; photoreceptor cell outer segment organization [GO:0035845]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; response to low light intensity stimulus [GO:0009645]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	membrane [GO:0016020]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	protein homodimerization activity [GO:0042803]	membrane [GO:0016020]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; protein homodimerization activity [GO:0042803]; cell adhesion [GO:0007155]; detection of light stimulus involved in visual perception [GO:0050908]; photoreceptor cell outer segment organization [GO:0035845]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; response to low light intensity stimulus [GO:0009645]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P17810}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P15499}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P15499}.
P23945	reviewed	FSHR_HUMAN	Follicle-stimulating hormone receptor (FSH-R) (Follitropin receptor)	FSHR LGR1	Homo sapiens (Human)	695	FUNCTION: G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690). {ECO:0000269|PubMed:11847099, ECO:0000269|PubMed:24058690, ECO:0000269|PubMed:24692546}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; female gamete generation [GO:0007292]; female gonad development [GO:0008585]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; gonad development [GO:0008406]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of protein kinase A signaling [GO:0010738]; spermatogenesis [GO:0007283]	membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	follicle-stimulating hormone receptor activity [GO:0004963]; G protein-coupled peptide receptor activity [GO:0008528]	membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; follicle-stimulating hormone receptor activity [GO:0004963]; G protein-coupled peptide receptor activity [GO:0008528]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; female gamete generation [GO:0007292]; female gonad development [GO:0008585]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; gonad development [GO:0008406]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of protein kinase A signaling [GO:0010738]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11847099, ECO:0000269|PubMed:24692546}; Multi-pass membrane protein {ECO:0000305}.
P23946	reviewed	CMA1_HUMAN	Chymase (EC 3.4.21.39) (Alpha-chymase) (Mast cell protease I)	CMA1 CYH CYM	Homo sapiens (Human)	247	FUNCTION: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.		angiotensin maturation [GO:0002003]; basement membrane disassembly [GO:0034769]; cellular response to glucose stimulus [GO:0071333]; cytokine precursor processing [GO:0140447]; extracellular matrix disassembly [GO:0022617]; midbrain development [GO:0030901]; positive regulation of angiogenesis [GO:0045766]; protein catabolic process [GO:0030163]; regulation of inflammatory response [GO:0050727]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; secretory granule [GO:0030141]	endopeptidase activity [GO:0004175]; peptide binding [GO:0042277]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; secretory granule [GO:0030141]; endopeptidase activity [GO:0004175]; peptide binding [GO:0042277]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; angiotensin maturation [GO:0002003]; basement membrane disassembly [GO:0034769]; cellular response to glucose stimulus [GO:0071333]; cytokine precursor processing [GO:0140447]; extracellular matrix disassembly [GO:0022617]; midbrain development [GO:0030901]; positive regulation of angiogenesis [GO:0045766]; protein catabolic process [GO:0030163]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule. Note=Mast cell granules.
P23975	reviewed	SC6A2_HUMAN	Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2)	SLC6A2 NAT1 NET1 SLC6A5	Homo sapiens (Human)	617	FUNCTION: Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:2008212, PubMed:8125921). Can also mediate sodium- and chloride-dependent transport of dopamine (PubMed:8125921, PubMed:11093780). {ECO:0000269|PubMed:11093780, ECO:0000269|PubMed:2008212, ECO:0000269|PubMed:8125921}.	MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.	chemical synaptic transmission [GO:0007268]; dopamine uptake involved in synaptic transmission [GO:0051583]; monoamine transport [GO:0015844]; neuron cellular homeostasis [GO:0070050]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sodium ion transmembrane transport [GO:0035725]	cell surface [GO:0009986]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; dopamine:sodium symporter activity [GO:0005330]; metal ion binding [GO:0046872]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; neurotransmitter:sodium symporter activity [GO:0005328]; norepinephrine:sodium symporter activity [GO:0005334]	cell surface [GO:0009986]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; dopamine:sodium symporter activity [GO:0005330]; metal ion binding [GO:0046872]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; neurotransmitter:sodium symporter activity [GO:0005328]; norepinephrine:sodium symporter activity [GO:0005334]; chemical synaptic transmission [GO:0007268]; dopamine uptake involved in synaptic transmission [GO:0051583]; monoamine transport [GO:0015844]; neuron cellular homeostasis [GO:0070050]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11343649}; Multi-pass membrane protein {ECO:0000255}.
P24001	reviewed	IL32_HUMAN	Interleukin-32 (IL-32) (Natural killer cells protein 4) (Tumor necrosis factor alpha-inducing factor)	IL32 NK4 TAIF	Homo sapiens (Human)	234	FUNCTION: Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. {ECO:0000269|PubMed:15664165}.		cell adhesion [GO:0007155]; defense response [GO:0006952]; immune response [GO:0006955]; negative regulation of viral life cycle [GO:1903901]; positive regulation of gene expression [GO:0010628]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of type III interferon production [GO:0034346]	cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]	cytokine activity [GO:0005125]	cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; cytokine activity [GO:0005125]; cell adhesion [GO:0007155]; defense response [GO:0006952]; immune response [GO:0006955]; negative regulation of viral life cycle [GO:1903901]; positive regulation of gene expression [GO:0010628]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of type III interferon production [GO:0034346]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15664165}.
P24043	reviewed	LAMA2_HUMAN	Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain)	LAMA2 LAMM	Homo sapiens (Human)	3122	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.		axon guidance [GO:0007411]; cell adhesion [GO:0007155]; maintenance of blood-brain barrier [GO:0035633]; muscle organ development [GO:0007517]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; regulation of basement membrane organization [GO:0110011]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; Schwann cell differentiation [GO:0014037]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; neuromuscular junction [GO:0031594]; protein complex involved in cell-matrix adhesion [GO:0098637]; sarcolemma [GO:0042383]; synaptic cleft [GO:0043083]	signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; neuromuscular junction [GO:0031594]; protein complex involved in cell-matrix adhesion [GO:0098637]; sarcolemma [GO:0042383]; synaptic cleft [GO:0043083]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; maintenance of blood-brain barrier [GO:0035633]; muscle organ development [GO:0007517]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; regulation of basement membrane organization [GO:0110011]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; Schwann cell differentiation [GO:0014037]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
P24046	reviewed	GBRR1_HUMAN	Gamma-aminobutyric acid receptor subunit rho-1 (GABA(A) receptor subunit rho-1) (GABA(C) receptor)	GABRR1	Homo sapiens (Human)	479	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.		chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; modulation of chemical synaptic transmission [GO:0050804]	chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]	chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; neurotransmitter receptor activity [GO:0030594]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]	chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; neurotransmitter receptor activity [GO:0030594]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; modulation of chemical synaptic transmission [GO:0050804]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
P24071	reviewed	FCAR_HUMAN	Immunoglobulin alpha Fc receptor (IgA Fc receptor) (CD antigen CD89)	FCAR CD89	Homo sapiens (Human)	287	FUNCTION: Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. {ECO:0000269|PubMed:12768205}.	MISCELLANEOUS: [Isoform B-delta-S2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to interferon-alpha [GO:0035457]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; Fc receptor signaling pathway [GO:0038093]; immune response [GO:0006955]; neutrophil activation [GO:0042119]; neutrophil mediated immunity [GO:0002446]; positive regulation of neutrophil apoptotic process [GO:0033031]	extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	IgA binding [GO:0019862]; IgA receptor activity [GO:0019766]	extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; IgA binding [GO:0019862]; IgA receptor activity [GO:0019766]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to interferon-alpha [GO:0035457]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; Fc receptor signaling pathway [GO:0038093]; immune response [GO:0006955]; neutrophil activation [GO:0042119]; neutrophil mediated immunity [GO:0002446]; positive regulation of neutrophil apoptotic process [GO:0033031]	SUBCELLULAR LOCATION: [Isoform A.1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform A.2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform A.3]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform B]: Secreted.; SUBCELLULAR LOCATION: [Isoform B-delta-S2]: Secreted.
P24158	reviewed	PRTN3_HUMAN	Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)	PRTN3 MBN	Homo sapiens (Human)	256	FUNCTION: Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). {ECO:0000269|PubMed:2033050, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:23202369, ECO:0000269|PubMed:28240246, ECO:0000269|PubMed:3198760}.		antimicrobial humoral response [GO:0019730]; cell-cell junction maintenance [GO:0045217]; collagen catabolic process [GO:0030574]; mature conventional dendritic cell differentiation [GO:0097029]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of phagocytosis [GO:0050765]; neutrophil extravasation [GO:0072672]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of GTPase activity [GO:0043547]; proteolysis [GO:0006508]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]	enzyme binding [GO:0019899]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; enzyme binding [GO:0019899]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102]; antimicrobial humoral response [GO:0019730]; cell-cell junction maintenance [GO:0045217]; collagen catabolic process [GO:0030574]; mature conventional dendritic cell differentiation [GO:0097029]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of phagocytosis [GO:0050765]; neutrophil extravasation [GO:0072672]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of GTPase activity [GO:0043547]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:2033050, ECO:0000269|PubMed:3198760, ECO:0000269|PubMed:7897245, ECO:0000305|PubMed:17244676}. Secreted {ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:28240246}. Cell membrane {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246}; Peripheral membrane protein {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246}; Extracellular side {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246}. Membrane raft {ECO:0000269|PubMed:21193407}; Peripheral membrane protein {ECO:0000269|PubMed:21193407}; Extracellular side {ECO:0000269|PubMed:21193407}. Note=Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils (PubMed:2033050, PubMed:3198760, PubMed:7897245, PubMed:18462208). Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (PubMed:22266279, PubMed:28240246). Following secretion tethered to the cell membrane by CD177 (PubMed:18462208, PubMed:22266279). {ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:2033050, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246, ECO:0000269|PubMed:3198760, ECO:0000269|PubMed:7897245}.
P24278	reviewed	ZBT25_HUMAN	Zinc finger and BTB domain-containing protein 25 (Zinc finger protein 46) (Zinc finger protein KUP)	ZBTB25 C14orf51 KUP ZNF46	Homo sapiens (Human)	435	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	nucleoplasm [GO:0005654]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus.
P24298	reviewed	ALAT1_HUMAN	Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1)	GPT AAT1 GPT1	Homo sapiens (Human)	496	FUNCTION: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). {ECO:0000250}.		biosynthetic process [GO:0009058]; cellular response to insulin stimulus [GO:0032869]; L-alanine catabolic process [GO:0042853]; positive regulation of gluconeogenesis [GO:0045722]; response to starvation [GO:0042594]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]; biosynthetic process [GO:0009058]; cellular response to insulin stimulus [GO:0032869]; L-alanine catabolic process [GO:0042853]; positive regulation of gluconeogenesis [GO:0045722]; response to starvation [GO:0042594]	SUBCELLULAR LOCATION: Cytoplasm.
P24310	reviewed	CX7A1_HUMAN	Cytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c oxidase subunit VIIa-heart) (Cytochrome c oxidase subunit VIIa-H) (Cytochrome c oxidase subunit VIIa-muscle) (Cytochrome c oxidase subunit VIIa-M)	COX7A1 COX7AH	Homo sapiens (Human)	79	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10174}.		generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]	mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]	cytochrome-c oxidase activity [GO:0004129]	mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; cytochrome-c oxidase activity [GO:0004129]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07470}; Single-pass membrane protein {ECO:0000250|UniProtKB:P07470}.
P24311	reviewed	COX7B_HUMAN	Cytochrome c oxidase subunit 7B, mitochondrial (Cytochrome c oxidase polypeptide VIIb)	COX7B	Homo sapiens (Human)	80	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity). Plays a role in proper central nervous system (CNS) development in vertebrates (PubMed:23122588). {ECO:0000250|UniProtKB:P13183, ECO:0000269|PubMed:23122588}.		cellular respiration [GO:0045333]; central nervous system development [GO:0007417]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]	cytochrome-c oxidase activity [GO:0004129]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]; cytochrome-c oxidase activity [GO:0004129]; cellular respiration [GO:0045333]; central nervous system development [GO:0007417]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
P24347	reviewed	MMP11_HUMAN	Stromelysin-3 (SL-3) (ST3) (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11)	MMP11 STMY3	Homo sapiens (Human)	488	FUNCTION: May play an important role in the progression of epithelial malignancies.		basement membrane organization [GO:0071711]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; negative regulation of fat cell differentiation [GO:0045599]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]	metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; basement membrane organization [GO:0071711]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; negative regulation of fat cell differentiation [GO:0045599]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
P24385	reviewed	CCND1_HUMAN	G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)	CCND1 BCL1 PRAD1	Homo sapiens (Human)	295	FUNCTION: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162, PubMed:33854235). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162). Hypophosphorylates RB1 in early G(1) phase (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:1833066, PubMed:1827756, PubMed:8302605, PubMed:19412162). Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed:15241418). Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:9106657). Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed:16569215, PubMed:18417529). {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:1827756, ECO:0000269|PubMed:1833066, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:19412162, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:8114739, ECO:0000269|PubMed:8302605, ECO:0000269|PubMed:9106657}.		cell division [GO:0051301]; DNA damage response [GO:0006974]; endoplasmic reticulum unfolded protein response [GO:0030968]; fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; lactation [GO:0007595]; liver regeneration [GO:0097421]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell proliferation [GO:0033598]; mitotic cell cycle phase transition [GO:0044772]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of protein phosphorylation [GO:0001934]; re-entry into mitotic cell cycle [GO:0000320]; response to leptin [GO:0044321]; response to UV-A [GO:0070141]; response to xenobiotic stimulus [GO:0009410]; Wnt signaling pathway [GO:0016055]	bicellular tight junction [GO:0005923]; cyclin D1-CDK4 complex [GO:0097128]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; proline-rich region binding [GO:0070064]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; transcription corepressor activity [GO:0003714]	bicellular tight junction [GO:0005923]; cyclin D1-CDK4 complex [GO:0097128]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; proline-rich region binding [GO:0070064]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; transcription corepressor activity [GO:0003714]; cell division [GO:0051301]; DNA damage response [GO:0006974]; endoplasmic reticulum unfolded protein response [GO:0030968]; fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; lactation [GO:0007595]; liver regeneration [GO:0097421]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell proliferation [GO:0033598]; mitotic cell cycle phase transition [GO:0044772]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of protein phosphorylation [GO:0001934]; re-entry into mitotic cell cycle [GO:0000320]; response to leptin [GO:0044321]; response to UV-A [GO:0070141]; response to xenobiotic stimulus [GO:0009410]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20399237, ECO:0000269|PubMed:9106657}. Cytoplasm {ECO:0000269|PubMed:9106657}. Nucleus membrane {ECO:0000269|PubMed:9106657}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000269|PubMed:9106657}.
P24386	reviewed	RAE1_HUMAN	Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein)	CHM REP1 TCD	Homo sapiens (Human)	653	FUNCTION: Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. {ECO:0000269|PubMed:18532927, ECO:0000269|PubMed:7957092}.		protein geranylgeranylation [GO:0018344]; protein targeting to membrane [GO:0006612]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; Rab-protein geranylgeranyltransferase complex [GO:0005968]	GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; Rab-protein geranylgeranyltransferase complex [GO:0005968]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267]; protein geranylgeranylation [GO:0018344]; protein targeting to membrane [GO:0006612]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:7957092}.
P24387	reviewed	CRHBP_HUMAN	Corticotropin-releasing factor-binding protein (CRF-BP) (CRF-binding protein) (Corticotropin-releasing hormone-binding protein) (CRH-BP)	CRHBP CRFBP	Homo sapiens (Human)	322	FUNCTION: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.		behavioral response to ethanol [GO:0048149]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to cocaine [GO:0071314]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; cellular response to gonadotropin-releasing hormone [GO:0097211]; cellular response to potassium ion [GO:0035865]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; female pregnancy [GO:0007565]; hormone-mediated signaling pathway [GO:0009755]; inflammatory response [GO:0006954]; learning or memory [GO:0007611]; negative regulation of corticotropin secretion [GO:0051460]; negative regulation of corticotropin-releasing hormone receptor activity [GO:1900011]; regulated exocytosis [GO:0045055]; regulation of cellular response to stress [GO:0080135]; regulation of corticotropin secretion [GO:0051459]; regulation of NMDA receptor activity [GO:2000310]; signal transduction [GO:0007165]; synaptic transmission, dopaminergic [GO:0001963]	axon terminus [GO:0043679]; dendrite [GO:0030425]; dense core granule [GO:0031045]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microtubule [GO:0005874]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; perikaryon [GO:0043204]; secondary lysosome [GO:0005767]; secretory granule [GO:0030141]; varicosity [GO:0043196]	corticotropin-releasing hormone binding [GO:0051424]; peptide binding [GO:0042277]	axon terminus [GO:0043679]; dendrite [GO:0030425]; dense core granule [GO:0031045]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microtubule [GO:0005874]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; perikaryon [GO:0043204]; secondary lysosome [GO:0005767]; secretory granule [GO:0030141]; varicosity [GO:0043196]; corticotropin-releasing hormone binding [GO:0051424]; peptide binding [GO:0042277]; behavioral response to ethanol [GO:0048149]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to cocaine [GO:0071314]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; cellular response to gonadotropin-releasing hormone [GO:0097211]; cellular response to potassium ion [GO:0035865]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; female pregnancy [GO:0007565]; hormone-mediated signaling pathway [GO:0009755]; inflammatory response [GO:0006954]; learning or memory [GO:0007611]; negative regulation of corticotropin secretion [GO:0051460]; negative regulation of corticotropin-releasing hormone receptor activity [GO:1900011]; regulated exocytosis [GO:0045055]; regulation of cellular response to stress [GO:0080135]; regulation of corticotropin secretion [GO:0051459]; regulation of NMDA receptor activity [GO:2000310]; signal transduction [GO:0007165]; synaptic transmission, dopaminergic [GO:0001963]	SUBCELLULAR LOCATION: Secreted.
P24390	reviewed	ERD21_HUMAN	ER lumen protein-retaining receptor 1 (KDEL endoplasmic reticulum protein retention receptor 1) (KDEL receptor 1) (Putative MAPK-activating protein PM23)	KDELR1 ERD2.1	Homo sapiens (Human)	212	FUNCTION: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. {ECO:0000269|PubMed:11703931, ECO:0000269|PubMed:14517323, ECO:0000269|PubMed:18086916, ECO:0000269|PubMed:30846601, ECO:0000269|PubMed:8392934}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; T cell apoptotic process [GO:0070231]; T cell differentiation [GO:0030217]	cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]	ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046]	cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]; ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; T cell apoptotic process [GO:0070231]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:18086916, ECO:0000269|PubMed:2172835, ECO:0000269|PubMed:30846601, ECO:0000269|PubMed:8392934}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:18086916}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18086916, ECO:0000269|PubMed:30846601, ECO:0000269|PubMed:8392934}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:P33946}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. {ECO:0000269|PubMed:18086916, ECO:0000269|PubMed:30846601, ECO:0000269|PubMed:8392934}.
P24394	reviewed	IL4RA_HUMAN	Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]	IL4R IL4RA 582J2.1	Homo sapiens (Human)	825	FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269|PubMed:8124718}.; FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. {ECO:0000269|PubMed:8124718}.		cytokine-mediated signaling pathway [GO:0019221]; defense response to protozoan [GO:0042832]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; interleukin-4-mediated signaling pathway [GO:0035771]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; positive regulation of chemokine production [GO:0032722]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of macrophage activation [GO:0043032]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; production of molecular mediator involved in inflammatory response [GO:0002532]; signal transduction [GO:0007165]; T-helper 1 cell differentiation [GO:0045063]; T-helper 2 cell differentiation [GO:0045064]	centriolar satellite [GO:0034451]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine receptor activity [GO:0004896]; interleukin-4 receptor activity [GO:0004913]	centriolar satellite [GO:0034451]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine receptor activity [GO:0004896]; interleukin-4 receptor activity [GO:0004913]; cytokine-mediated signaling pathway [GO:0019221]; defense response to protozoan [GO:0042832]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; interleukin-4-mediated signaling pathway [GO:0035771]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; positive regulation of chemokine production [GO:0032722]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of macrophage activation [GO:0043032]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; production of molecular mediator involved in inflammatory response [GO:0002532]; signal transduction [GO:0007165]; T-helper 1 cell differentiation [GO:0045063]; T-helper 2 cell differentiation [GO:0045064]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
P24462	reviewed	CP3A7_HUMAN	Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (Cytochrome P450-HFLA) (P450HLp2)	CYP3A7	Homo sapiens (Human)	503	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis (PubMed:9555064, PubMed:11093772, PubMed:14559847, PubMed:12865317, PubMed:17178770). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9555064, PubMed:11093772, PubMed:14559847, PubMed:12865317, PubMed:17178770). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones (PubMed:9555064, PubMed:17178770). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position (PubMed:14559847, PubMed:12865317). Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics including anticonvulsants (PubMed:9555064). {ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:17178770, ECO:0000269|PubMed:9555064}.		estrogen metabolic process [GO:0008210]; lipid hydroxylation [GO:0002933]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]	all-trans retinoic acid 18-hydroxylase activity [GO:0062183]; aromatase activity [GO:0070330]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxygen binding [GO:0019825]; retinoic acid 4-hydroxylase activity [GO:0008401]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]	endoplasmic reticulum membrane [GO:0005789]; all-trans retinoic acid 18-hydroxylase activity [GO:0062183]; aromatase activity [GO:0070330]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxygen binding [GO:0019825]; retinoic acid 4-hydroxylase activity [GO:0008401]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]; estrogen metabolic process [GO:0008210]; lipid hydroxylation [GO:0002933]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane {ECO:0000305|PubMed:2492179}; Peripheral membrane protein.
P24468	reviewed	COT2_HUMAN	COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2)	NR2F2 ARP1 TFCOUP2	Homo sapiens (Human)	414	FUNCTION: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development (PubMed:29478779). {ECO:0000269|PubMed:18798693, ECO:0000269|PubMed:1899293, ECO:0000269|PubMed:29478779, ECO:0000269|PubMed:9343308}.		anatomical structure development [GO:0048856]; anterior/posterior pattern specification [GO:0009952]; blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; female gonad development [GO:0008585]; fertilization [GO:0009566]; forebrain development [GO:0030900]; interneuron migration [GO:1904936]; lymphatic endothelial cell fate commitment [GO:0060838]; maternal placenta development [GO:0001893]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of transcription by RNA polymerase II [GO:0000122]; placenta blood vessel development [GO:0060674]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of transcription by RNA polymerase II [GO:0045944]; radial pattern formation [GO:0009956]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; skeletal muscle tissue development [GO:0007519]; trophoblast giant cell differentiation [GO:0060707]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; nuclear receptor activity [GO:0004879]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; nuclear receptor activity [GO:0004879]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]; anatomical structure development [GO:0048856]; anterior/posterior pattern specification [GO:0009952]; blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; female gonad development [GO:0008585]; fertilization [GO:0009566]; forebrain development [GO:0030900]; interneuron migration [GO:1904936]; lymphatic endothelial cell fate commitment [GO:0060838]; maternal placenta development [GO:0001893]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of transcription by RNA polymerase II [GO:0000122]; placenta blood vessel development [GO:0060674]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of transcription by RNA polymerase II [GO:0045944]; radial pattern formation [GO:0009956]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; skeletal muscle tissue development [GO:0007519]; trophoblast giant cell differentiation [GO:0060707]	SUBCELLULAR LOCATION: Nucleus.
P24522	reviewed	GA45A_HUMAN	Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1)	GADD45A DDIT1 GADD45	Homo sapiens (Human)	165	FUNCTION: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. {ECO:0000250}.		apoptotic process [GO:0006915]; cellular response to ionizing radiation [GO:0071479]; cellular response to mechanical stimulus [GO:0071260]; centrosome cycle [GO:0007098]; DNA repair [GO:0006281]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033140]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; signal transduction in response to DNA damage [GO:0042770]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	kinase binding [GO:0019900]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; kinase binding [GO:0019900]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; apoptotic process [GO:0006915]; cellular response to ionizing radiation [GO:0071479]; cellular response to mechanical stimulus [GO:0071260]; centrosome cycle [GO:0007098]; DNA repair [GO:0006281]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033140]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; signal transduction in response to DNA damage [GO:0042770]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7973727}.
P24530	reviewed	EDNRB_HUMAN	Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type)	EDNRB ETRB	Homo sapiens (Human)	442	FUNCTION: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:7536888}.		aldosterone metabolic process [GO:0032341]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; canonical NF-kappaB signal transduction [GO:0007249]; canonical Wnt signaling pathway [GO:0060070]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; cGMP-mediated signaling [GO:0019934]; developmental pigmentation [GO:0048066]; endothelin receptor signaling pathway [GO:0086100]; enteric nervous system development [GO:0048484]; enteric smooth muscle cell differentiation [GO:0035645]; epithelial fluid transport [GO:0042045]; establishment of endothelial barrier [GO:0061028]; gene expression [GO:0010467]; heparin metabolic process [GO:0030202]; macrophage chemotaxis [GO:0048246]; melanocyte differentiation [GO:0030318]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron maturation [GO:0014043]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neuroblast migration [GO:0097402]; peripheral nervous system development [GO:0007422]; pharynx development [GO:0060465]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; podocyte differentiation [GO:0072112]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of penile erection [GO:0060406]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of urine volume [GO:0035810]; posterior midgut development [GO:0007497]; protein transmembrane transport [GO:0071806]; regulation of epithelial cell proliferation [GO:0050678]; regulation of fever generation [GO:0031620]; regulation of heart rate [GO:0002027]; regulation of pH [GO:0006885]; renal albumin absorption [GO:0097018]; renal sodium excretion [GO:0035812]; renal sodium ion absorption [GO:0070294]; renin secretion into blood stream [GO:0002001]; response to endothelin [GO:1990839]; response to organic cyclic compound [GO:0014070]; response to pain [GO:0048265]; response to sodium phosphate [GO:1904383]; vasoconstriction [GO:0042310]; vasodilation [GO:0042311]; vein smooth muscle contraction [GO:0014826]	nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	endothelin receptor activity [GO:0004962]; peptide hormone binding [GO:0017046]; type 1 angiotensin receptor binding [GO:0031702]	nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; endothelin receptor activity [GO:0004962]; peptide hormone binding [GO:0017046]; type 1 angiotensin receptor binding [GO:0031702]; aldosterone metabolic process [GO:0032341]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; canonical NF-kappaB signal transduction [GO:0007249]; canonical Wnt signaling pathway [GO:0060070]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; cGMP-mediated signaling [GO:0019934]; developmental pigmentation [GO:0048066]; endothelin receptor signaling pathway [GO:0086100]; enteric nervous system development [GO:0048484]; enteric smooth muscle cell differentiation [GO:0035645]; epithelial fluid transport [GO:0042045]; establishment of endothelial barrier [GO:0061028]; gene expression [GO:0010467]; heparin metabolic process [GO:0030202]; macrophage chemotaxis [GO:0048246]; melanocyte differentiation [GO:0030318]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron maturation [GO:0014043]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neuroblast migration [GO:0097402]; peripheral nervous system development [GO:0007422]; pharynx development [GO:0060465]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; podocyte differentiation [GO:0072112]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of penile erection [GO:0060406]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of urine volume [GO:0035810]; posterior midgut development [GO:0007497]; protein transmembrane transport [GO:0071806]; regulation of epithelial cell proliferation [GO:0050678]; regulation of fever generation [GO:0031620]; regulation of heart rate [GO:0002027]; regulation of pH [GO:0006885]; renal albumin absorption [GO:0097018]; renal sodium excretion [GO:0035812]; renal sodium ion absorption [GO:0070294]; renin secretion into blood stream [GO:0002001]; response to endothelin [GO:1990839]; response to organic cyclic compound [GO:0014070]; response to pain [GO:0048265]; response to sodium phosphate [GO:1904383]; vasoconstriction [GO:0042310]; vasodilation [GO:0042311]; vein smooth muscle contraction [GO:0014826]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28236341}; Multi-pass membrane protein. Note=internalized after activation by endothelins. {ECO:0000269|PubMed:28236341}.
P24534	reviewed	EF1B_HUMAN	Elongation factor 1-beta (EF-1-beta)	EEF1B2 EEF1B EF1B	Homo sapiens (Human)	225	FUNCTION: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.		translational elongation [GO:0006414]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853]	guanyl-nucleotide exchange factor activity [GO:0005085]; translation elongation factor activity [GO:0003746]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853]; guanyl-nucleotide exchange factor activity [GO:0005085]; translation elongation factor activity [GO:0003746]; translational elongation [GO:0006414]	
P24539	reviewed	AT5F1_HUMAN	ATP synthase F(0) complex subunit B1, mitochondrial (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b)	ATP5PB ATP5F1	Homo sapiens (Human)	256	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.		proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; substantia nigra development [GO:0021762]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	proton transmembrane transporter activity [GO:0015078]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; proton transmembrane transporter activity [GO:0015078]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane.
P24557	reviewed	THAS_HUMAN	Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)	TBXAS1 CYP5 CYP5A1 TXAS	Homo sapiens (Human)	533	FUNCTION: Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:8436233, PubMed:11297515, PubMed:9873013, PubMed:11097184, PubMed:24009185, PubMed:22735388). Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 (PubMed:11297515, PubMed:9873013, PubMed:22735388). Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (PubMed:17459323). {ECO:0000269|PubMed:11097184, ECO:0000269|PubMed:11297515, ECO:0000269|PubMed:17459323, ECO:0000269|PubMed:22735388, ECO:0000269|PubMed:24009185, ECO:0000269|PubMed:8436233, ECO:0000269|PubMed:9873013}.		cyclooxygenase pathway [GO:0019371]; icosanoid metabolic process [GO:0006690]; intracellular chloride ion homeostasis [GO:0030644]; positive regulation of vasoconstriction [GO:0045907]; prostaglandin biosynthetic process [GO:0001516]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	12-hydroxyheptadecatrienoic acid synthase activity [GO:0036134]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; thromboxane-A synthase activity [GO:0004796]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; 12-hydroxyheptadecatrienoic acid synthase activity [GO:0036134]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; thromboxane-A synthase activity [GO:0004796]; cyclooxygenase pathway [GO:0019371]; icosanoid metabolic process [GO:0006690]; intracellular chloride ion homeostasis [GO:0030644]; positive regulation of vasoconstriction [GO:0045907]; prostaglandin biosynthetic process [GO:0001516]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8366093}; Multi-pass membrane protein {ECO:0000255}.
P24588	reviewed	AKAP5_HUMAN	A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein)	AKAP5 AKAP79	Homo sapiens (Human)	427	FUNCTION: Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740). {ECO:0000269|PubMed:1512224, ECO:0000269|PubMed:25589740}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; negative regulation of adenylate cyclase activity [GO:0007194]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of endosome to plasma membrane protein transport [GO:1905751]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of protein kinase A signaling [GO:0010738]; signal transduction [GO:0007165]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendrite membrane [GO:0032590]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic recycling endosome [GO:0098837]; protein serine/threonine phosphatase complex [GO:0008287]	adenylate cyclase binding [GO:0008179]; beta-2 adrenergic receptor binding [GO:0031698]; calmodulin binding [GO:0005516]; GABA receptor binding [GO:0050811]; glutamate receptor binding [GO:0035254]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein phosphatase 2B binding [GO:0030346]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendrite membrane [GO:0032590]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic recycling endosome [GO:0098837]; protein serine/threonine phosphatase complex [GO:0008287]; adenylate cyclase binding [GO:0008179]; beta-2 adrenergic receptor binding [GO:0031698]; calmodulin binding [GO:0005516]; GABA receptor binding [GO:0050811]; glutamate receptor binding [GO:0035254]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein phosphatase 2B binding [GO:0030346]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; negative regulation of adenylate cyclase activity [GO:0007194]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of endosome to plasma membrane protein transport [GO:1905751]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of protein kinase A signaling [GO:0010738]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Postsynaptic recycling endosome membrane {ECO:0000269|PubMed:21771783, ECO:0000269|PubMed:25589740}; Lipid-anchor {ECO:0000269|PubMed:21771783}. Note=Associates with lipid rafts. {ECO:0000269|PubMed:21771783}.
P24592	reviewed	IBP6_HUMAN	Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6)	IGFBP6 IBP6	Homo sapiens (Human)	240	FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration (PubMed:24003225). {ECO:0000269|PubMed:24003225}.		cell migration [GO:0016477]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of stress-activated MAPK cascade [GO:0032874]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binary complex [GO:0042568]	fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binary complex [GO:0042568]; fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102]; cell migration [GO:0016477]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of stress-activated MAPK cascade [GO:0032874]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24003225}.
P24593	reviewed	IBP5_HUMAN	Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5)	IGFBP5 IBP5	Homo sapiens (Human)	272	FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.		cellular response to cAMP [GO:0071320]; cellular response to organic cyclic compound [GO:0071407]; female pregnancy [GO:0007565]; glucose homeostasis [GO:0042593]; hair follicle morphogenesis [GO:0031069]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; lung alveolus development [GO:0048286]; mammary gland involution [GO:0060056]; negative regulation of cell migration [GO:0030336]; negative regulation of growth [GO:0045926]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of muscle tissue development [GO:1901862]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of skeletal muscle hypertrophy [GO:1904205]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of translation [GO:0017148]; osteoblast differentiation [GO:0001649]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of cell growth [GO:0001558]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to growth hormone [GO:0060416]; signal transduction [GO:0007165]; striated muscle cell differentiation [GO:0051146]; type B pancreatic cell proliferation [GO:0044342]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binding protein complex [GO:0016942]; insulin-like growth factor ternary complex [GO:0042567]	fibronectin binding [GO:0001968]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binding protein complex [GO:0016942]; insulin-like growth factor ternary complex [GO:0042567]; fibronectin binding [GO:0001968]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; cellular response to cAMP [GO:0071320]; cellular response to organic cyclic compound [GO:0071407]; female pregnancy [GO:0007565]; glucose homeostasis [GO:0042593]; hair follicle morphogenesis [GO:0031069]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; lung alveolus development [GO:0048286]; mammary gland involution [GO:0060056]; negative regulation of cell migration [GO:0030336]; negative regulation of growth [GO:0045926]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of muscle tissue development [GO:1901862]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of skeletal muscle hypertrophy [GO:1904205]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of translation [GO:0017148]; osteoblast differentiation [GO:0001649]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of cell growth [GO:0001558]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to growth hormone [GO:0060416]; signal transduction [GO:0007165]; striated muscle cell differentiation [GO:0051146]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Secreted.
P24666	reviewed	PPAC_HUMAN	Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1)	ACP1	Homo sapiens (Human)	158	FUNCTION: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2. {ECO:0000269|PubMed:10336608, ECO:0000269|PubMed:9705307}.; FUNCTION: [Isoform 3]: Does not possess phosphatase activity. {ECO:0000269|PubMed:10336608}.			cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; sarcolemma [GO:0042383]	acid phosphatase activity [GO:0003993]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; sarcolemma [GO:0042383]; acid phosphatase activity [GO:0003993]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]	SUBCELLULAR LOCATION: Cytoplasm.
P24723	reviewed	KPCL_HUMAN	Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta)	PRKCH PKCL PRKCL	Homo sapiens (Human)	683	FUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. {ECO:0000269|PubMed:10806212, ECO:0000269|PubMed:11112424, ECO:0000269|PubMed:11772428, ECO:0000269|PubMed:15489897, ECO:0000269|PubMed:17146445, ECO:0000269|PubMed:18780722, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:20558593, ECO:0000269|PubMed:21820409, ECO:0000269|PubMed:22304920}.		cell differentiation [GO:0030154]; intracellular signal transduction [GO:0035556]; negative regulation of glial cell apoptotic process [GO:0034351]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein kinase C signaling [GO:0070528]; protein phosphorylation [GO:0006468]; regulation of bicellular tight junction assembly [GO:2000810]; signal transduction [GO:0007165]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; calcium-independent protein kinase C activity [GO:0004699]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; calcium-independent protein kinase C activity [GO:0004699]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]; cell differentiation [GO:0030154]; intracellular signal transduction [GO:0035556]; negative regulation of glial cell apoptotic process [GO:0034351]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein kinase C signaling [GO:0070528]; protein phosphorylation [GO:0006468]; regulation of bicellular tight junction assembly [GO:2000810]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
P24752	reviewed	THIL_HUMAN	Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2)	ACAT1 ACAT MAT	Homo sapiens (Human)	427	FUNCTION: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:17371050, PubMed:1715688, PubMed:7728148, PubMed:9744475). {ECO:0000269|PubMed:1715688, ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148, ECO:0000269|PubMed:9744475}.		acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA catabolic process [GO:0046356]; adipose tissue development [GO:0060612]; coenzyme A biosynthetic process [GO:0015937]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; isoleucine catabolic process [GO:0006550]; ketone body catabolic process [GO:0046952]; ketone body metabolic process [GO:1902224]; liver development [GO:0001889]; metanephric proximal convoluted tubule development [GO:0072229]; propionyl-CoA biosynthetic process [GO:1902860]; response to hormone [GO:0009725]; response to organic cyclic compound [GO:0014070]; response to starvation [GO:0042594]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	acetyl-CoA C-acetyltransferase activity [GO:0003985]; C-acetyltransferase activity [GO:0016453]; cholesterol O-acyltransferase activity [GO:0034736]; coenzyme A binding [GO:0120225]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; potassium ion binding [GO:0030955]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; C-acetyltransferase activity [GO:0016453]; cholesterol O-acyltransferase activity [GO:0034736]; coenzyme A binding [GO:0120225]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; potassium ion binding [GO:0030955]; acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA catabolic process [GO:0046356]; adipose tissue development [GO:0060612]; coenzyme A biosynthetic process [GO:0015937]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; isoleucine catabolic process [GO:0006550]; ketone body catabolic process [GO:0046952]; ketone body metabolic process [GO:1902224]; liver development [GO:0001889]; metanephric proximal convoluted tubule development [GO:0072229]; propionyl-CoA biosynthetic process [GO:1902860]; response to hormone [GO:0009725]; response to organic cyclic compound [GO:0014070]; response to starvation [GO:0042594]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:1979337}.
P24821	reviewed	TENA_HUMAN	Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C)	TNC HXB	Homo sapiens (Human)	2201	FUNCTION: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}.		bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; prostate gland epithelium morphogenesis [GO:0060740]; regulation of cell adhesion [GO:0030155]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of inflammatory response [GO:0050727]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; response to wounding [GO:0009611]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; interstitial matrix [GO:0005614]; membrane [GO:0016020]; perisynaptic extracellular matrix [GO:0098966]; tenascin complex [GO:0090733]	extracellular matrix structural constituent [GO:0005201]; syndecan binding [GO:0045545]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; interstitial matrix [GO:0005614]; membrane [GO:0016020]; perisynaptic extracellular matrix [GO:0098966]; tenascin complex [GO:0090733]; extracellular matrix structural constituent [GO:0005201]; syndecan binding [GO:0045545]; bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; prostate gland epithelium morphogenesis [GO:0060740]; regulation of cell adhesion [GO:0030155]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of inflammatory response [GO:0050727]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
P24844	reviewed	MYL9_HUMAN	Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1)	MYL9 MLC2 MRLC1 MYRL2	Homo sapiens (Human)	172	FUNCTION: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). {ECO:0000250|UniProtKB:Q9CQ19, ECO:0000269|PubMed:11942626, ECO:0000269|PubMed:2526655}.	MISCELLANEOUS: This chain binds calcium.	myofibril assembly [GO:0030239]; platelet aggregation [GO:0070527]; regulation of muscle contraction [GO:0006937]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; stress fiber [GO:0001725]; Z disc [GO:0030018]	calcium ion binding [GO:0005509]; myosin heavy chain binding [GO:0032036]; structural constituent of muscle [GO:0008307]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; stress fiber [GO:0001725]; Z disc [GO:0030018]; calcium ion binding [GO:0005509]; myosin heavy chain binding [GO:0032036]; structural constituent of muscle [GO:0008307]; myofibril assembly [GO:0030239]; platelet aggregation [GO:0070527]; regulation of muscle contraction [GO:0006937]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9CQ19}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9CQ19}. Note=Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts. {ECO:0000250|UniProtKB:Q9CQ19}.
P24855	reviewed	DNAS1_HUMAN	Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) (Dornase alfa)	DNASE1 DNL1 DRNI	Homo sapiens (Human)	282	FUNCTION: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). {ECO:0000250|UniProtKB:P00639, ECO:0000250|UniProtKB:P21704, ECO:0000250|UniProtKB:P49183, ECO:0000269|PubMed:11241278, ECO:0000269|PubMed:2251263, ECO:0000269|PubMed:2277032}.		apoptotic process [GO:0006915]; DNA catabolic process [GO:0006308]; neutrophil activation involved in immune response [GO:0002283]; regulation of acute inflammatory response [GO:0002673]; regulation of neutrophil mediated cytotoxicity [GO:0070948]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; zymogen granule [GO:0042588]	actin binding [GO:0003779]; deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; zymogen granule [GO:0042588]; actin binding [GO:0003779]; deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]; apoptotic process [GO:0006915]; DNA catabolic process [GO:0006308]; neutrophil activation involved in immune response [GO:0002283]; regulation of acute inflammatory response [GO:0002673]; regulation of neutrophil mediated cytotoxicity [GO:0070948]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2277032}. Zymogen granule {ECO:0000305}. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope.
P24863	reviewed	CCNC_HUMAN	Cyclin-C (SRB11 homolog) (hSRB11)	CCNC	Homo sapiens (Human)	283	FUNCTION: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. {ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:8700522}.		G0 to G1 transition [GO:0045023]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of transcription by RNA polymerase II [GO:0045944]	CKM complex [GO:1990508]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; identical protein binding [GO:0042802]	CKM complex [GO:1990508]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; identical protein binding [GO:0042802]; G0 to G1 transition [GO:0045023]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P24864	reviewed	CCNE1_HUMAN	G1/S-specific cyclin-E1	CCNE1 CCNE	Homo sapiens (Human)	410	FUNCTION: Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}.	MISCELLANEOUS: [Isoform E1S]: Lacks 49 residues within the cyclin box and cannot complex with CDK2. {ECO:0000305}.	cell division [GO:0051301]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; homologous chromosome pairing at meiosis [GO:0007129]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of protein localization [GO:0032880]; telomere maintenance [GO:0000723]; Wnt signaling pathway [GO:0016055]	centrosome [GO:0005813]; cyclin E1-CDK2 complex [GO:0097134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; kinase activity [GO:0016301]; protein kinase binding [GO:0019901]	centrosome [GO:0005813]; cyclin E1-CDK2 complex [GO:0097134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; kinase activity [GO:0016301]; protein kinase binding [GO:0019901]; cell division [GO:0051301]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; homologous chromosome pairing at meiosis [GO:0007129]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of protein localization [GO:0032880]; telomere maintenance [GO:0000723]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7739542}.
P24903	reviewed	CP2F1_HUMAN	Cytochrome P450 2F1 (EC 1.14.14.1) (CYPIIF1)	CYP2F1	Homo sapiens (Human)	491	FUNCTION: May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. {ECO:0000269|PubMed:1974816}.		epoxygenase P450 pathway [GO:0019373]; naphthalene catabolic process [GO:1901170]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; epoxygenase P450 pathway [GO:0019373]; naphthalene catabolic process [GO:1901170]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:10383923}; Peripheral membrane protein {ECO:0000305|PubMed:10383923}. Microsome membrane {ECO:0000269|PubMed:10383923}; Peripheral membrane protein {ECO:0000269|PubMed:10383923}.
P24928	reviewed	RPB1_HUMAN	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	POLR2A POLR2	Homo sapiens (Human)	1970	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Regulation of gene expression levels depends on the balance between methylation and acetylation levels of tha CTD-lysines (By similarity). Initiation or early elongation steps of transcription of growth-factors-induced immediate early genes are regulated by the acetylation status of the CTD (PubMed:24207025). Methylation and dimethylation have a repressive effect on target genes expression (By similarity). {ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:9852112}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.	MISCELLANEOUS: The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion.	DNA-templated transcription termination [GO:0006353]; positive regulation of RNA splicing [GO:0033120]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; microfibril binding [GO:0050436]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; RNA polymerase II activity [GO:0001055]; RNA-dependent RNA polymerase activity [GO:0003968]; ubiquitin protein ligase binding [GO:0031625]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; microfibril binding [GO:0050436]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; RNA polymerase II activity [GO:0001055]; RNA-dependent RNA polymerase activity [GO:0003968]; ubiquitin protein ligase binding [GO:0031625]; DNA-templated transcription termination [GO:0006353]; positive regulation of RNA splicing [GO:0033120]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26566685, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9852112}. Cytoplasm {ECO:0000269|PubMed:26566685}. Chromosome {ECO:0000269|PubMed:28076779}. Note=Hypophosphorylated form is mainly found in the cytoplasm, while the hyperphosphorylated and active form is nuclear (PubMed:26566685). Co-localizes with kinase SRPK2 and helicase DDX23 at chromatin loci where unscheduled R-loops form (PubMed:28076779). {ECO:0000269|PubMed:26566685, ECO:0000269|PubMed:28076779}.
P24941	reviewed	CDK2_HUMAN	Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)	CDK2 CDKN2	Homo sapiens (Human)	298	FUNCTION: Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). {ECO:0000250|UniProtKB:P97377, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:11051553, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:12944431, ECO:0000269|PubMed:15800615, ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:18372919, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20079829, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20195506, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:21319273, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:28666995, ECO:0000269|PubMed:29203878}.		cell division [GO:0051301]; cellular response to nitric oxide [GO:0071732]; cellular senescence [GO:0090398]; centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated transcription [GO:0006351]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; meiotic cell cycle [GO:0051321]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated DNA replication initiation [GO:0032298]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of heterochromatin formation [GO:0031453]; post-translational protein modification [GO:0043687]; potassium ion transport [GO:0006813]; protein phosphorylation [GO:0006468]; Ras protein signal transduction [GO:0007265]; regulation of anaphase-promoting complex-dependent catabolic process [GO:1905784]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; response to organic substance [GO:0010033]; signal transduction [GO:0007165]	Cajal body [GO:0015030]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; cyclin A1-CDK2 complex [GO:0097123]; cyclin A2-CDK2 complex [GO:0097124]; cyclin E1-CDK2 complex [GO:0097134]; cyclin E2-CDK2 complex [GO:0097135]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; male germ cell nucleus [GO:0001673]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; X chromosome [GO:0000805]; Y chromosome [GO:0000806]	ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein kinase activity [GO:0097472]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; magnesium ion binding [GO:0000287]; protein domain specific binding [GO:0019904]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	Cajal body [GO:0015030]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; cyclin A1-CDK2 complex [GO:0097123]; cyclin A2-CDK2 complex [GO:0097124]; cyclin E1-CDK2 complex [GO:0097134]; cyclin E2-CDK2 complex [GO:0097135]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; male germ cell nucleus [GO:0001673]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; X chromosome [GO:0000805]; Y chromosome [GO:0000806]; ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein kinase activity [GO:0097472]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; magnesium ion binding [GO:0000287]; protein domain specific binding [GO:0019904]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell division [GO:0051301]; cellular response to nitric oxide [GO:0071732]; cellular senescence [GO:0090398]; centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated transcription [GO:0006351]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; meiotic cell cycle [GO:0051321]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated DNA replication initiation [GO:0032298]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of heterochromatin formation [GO:0031453]; post-translational protein modification [GO:0043687]; potassium ion transport [GO:0006813]; protein phosphorylation [GO:0006468]; Ras protein signal transduction [GO:0007265]; regulation of anaphase-promoting complex-dependent catabolic process [GO:1905784]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; response to organic substance [GO:0010033]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).
P25021	reviewed	HRH2_HUMAN	Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I)	HRH2	Homo sapiens (Human)	359	FUNCTION: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity). {ECO:0000250}.	MISCELLANEOUS: Antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the gastrointestinal tract. Certain antagonists are used in the treatment of neuropsychiatric and neurological diseases such as schizophrenia, Alzheimer disease and Parkinson disease.	chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gastric acid secretion [GO:0001696]; immune response [GO:0006955]; positive regulation of vasoconstriction [GO:0045907]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gastric acid secretion [GO:0001696]; immune response [GO:0006955]; positive regulation of vasoconstriction [GO:0045907]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P25024	reviewed	CXCR1_HUMAN	C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)	CXCR1 CMKAR1 IL8RA	Homo sapiens (Human)	350	FUNCTION: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor (PubMed:1840701). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). {ECO:0000269|PubMed:1840701, ECO:0000269|PubMed:8662698}.		calcium-mediated signaling [GO:0019722]; cell surface receptor signaling pathway [GO:0007166]; dendritic cell chemotaxis [GO:0002407]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; neutrophil chemotaxis [GO:0030593]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; receptor internalization [GO:0031623]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; G protein-coupled receptor activity [GO:0004930]; interleukin-8 binding [GO:0019959]; interleukin-8 receptor activity [GO:0004918]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; G protein-coupled receptor activity [GO:0004930]; interleukin-8 binding [GO:0019959]; interleukin-8 receptor activity [GO:0004918]; calcium-mediated signaling [GO:0019722]; cell surface receptor signaling pathway [GO:0007166]; dendritic cell chemotaxis [GO:0002407]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; neutrophil chemotaxis [GO:0030593]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; receptor internalization [GO:0031623]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P25025	reviewed	CXCR2_HUMAN	C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182)	CXCR2 IL8RB	Homo sapiens (Human)	360	FUNCTION: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. {ECO:0000269|PubMed:1891716, ECO:0000269|PubMed:8662698}.		acute inflammatory response to antigenic stimulus [GO:0002438]; calcium-mediated signaling [GO:0019722]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-8-mediated signaling pathway [GO:0038112]; metanephric tubule morphogenesis [GO:0072173]; midbrain development [GO:0030901]; negative regulation of neutrophil apoptotic process [GO:0033030]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of vascular permeability [GO:0043117]; receptor internalization [GO:0031623]; signal transduction [GO:0007165]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; mast cell granule [GO:0042629]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine receptor activity [GO:0016494]; G protein-coupled receptor activity [GO:0004930]; interleukin-8 binding [GO:0019959]; interleukin-8 receptor activity [GO:0004918]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; mast cell granule [GO:0042629]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine receptor activity [GO:0016494]; G protein-coupled receptor activity [GO:0004930]; interleukin-8 binding [GO:0019959]; interleukin-8 receptor activity [GO:0004918]; acute inflammatory response to antigenic stimulus [GO:0002438]; calcium-mediated signaling [GO:0019722]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-8-mediated signaling pathway [GO:0038112]; metanephric tubule morphogenesis [GO:0072173]; midbrain development [GO:0030901]; negative regulation of neutrophil apoptotic process [GO:0033030]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of vascular permeability [GO:0043117]; receptor internalization [GO:0031623]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P25054	reviewed	APC_HUMAN	Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)	APC DP2.5	Homo sapiens (Human)	2843	FUNCTION: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.	MISCELLANEOUS: APC mutations have led to some interesting observations. (1) the great majority of the mutations found to date would result in truncation of the APC product. (2) almost all the mutations have occurred within the first half of the coding sequence, and somatic mutations in colorectal tumors are further clustered in a particular region, called MCR (mutation cluster region). (3) most identified point mutations in the APC gene are transitions from cytosine to other nucleotides. (4) the location of germline mutations tends to correlate with the number of colorectal polyps in FAP1 patients. Inactivation of both alleles of the APC gene seems to be required as an early event to develop most adenomas and carcinomas in the colon and rectum as well as some of those in the stomach.; MISCELLANEOUS: [Isoform 1B]: Produced by alternative promoter usage. {ECO:0000269|PubMed:19527921}.	bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; cell migration [GO:0016477]; DNA damage response [GO:0006974]; endocardial cushion morphogenesis [GO:0003203]; heart valve development [GO:0003170]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; pattern specification process [GO:0007389]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of pseudopodium assembly [GO:0031274]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of cell differentiation [GO:0045595]; regulation of microtubule-based process [GO:0032886]; Wnt signaling pathway [GO:0016055]	adherens junction [GO:0005912]; beta-catenin destruction complex [GO:0030877]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; Wnt signalosome [GO:1990909]	beta-catenin binding [GO:0008013]; dynein complex binding [GO:0070840]; gamma-catenin binding [GO:0045295]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; ubiquitin protein ligase binding [GO:0031625]	adherens junction [GO:0005912]; beta-catenin destruction complex [GO:0030877]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; Wnt signalosome [GO:1990909]; beta-catenin binding [GO:0008013]; dynein complex binding [GO:0070840]; gamma-catenin binding [GO:0045295]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; ubiquitin protein ligase binding [GO:0031625]; bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; cell migration [GO:0016477]; DNA damage response [GO:0006974]; endocardial cushion morphogenesis [GO:0003203]; heart valve development [GO:0003170]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; pattern specification process [GO:0007389]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of pseudopodium assembly [GO:0031274]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of cell differentiation [GO:0045595]; regulation of microtubule-based process [GO:0032886]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:16611247}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:20937854}. Cell projection, lamellipodium {ECO:0000269|PubMed:19151759}. Cell projection, ruffle membrane {ECO:0000269|PubMed:19151759}. Cytoplasm {ECO:0000269|PubMed:10947987}. Cell membrane {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:16611247, ECO:0000269|PubMed:20937854}. Note=Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). MAPRE1 may be required for targeting to the growing microtubule plus ends (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). {ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:20937854}.
P25063	reviewed	CD24_HUMAN	Signal transducer CD24 (Small cell lung carcinoma cluster 4 antigen) (CD antigen CD24)	CD24 CD24A	Homo sapiens (Human)	80	FUNCTION: May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity). {ECO:0000250|UniProtKB:P24807, ECO:0000269|PubMed:11313396}.		B cell receptor transport into membrane raft [GO:0032597]; cell activation [GO:0001775]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; chemokine receptor transport out of membrane raft [GO:0032600]; cholesterol homeostasis [GO:0042632]; glomerular parietal epithelial cell differentiation [GO:0072139]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of transforming growth factor beta3 production [GO:0032913]; podocyte differentiation [GO:0072112]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; regulation of cytokine-mediated signaling pathway [GO:0001959]; regulation of epithelial cell differentiation [GO:0030856]; regulation of MAPK cascade [GO:0043408]; regulation of phosphorylation [GO:0042325]; respiratory burst [GO:0045730]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to molecule of bacterial origin [GO:0002237]; T cell costimulation [GO:0031295]; Wnt signaling pathway [GO:0016055]	cell surface [GO:0009986]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	protein kinase binding [GO:0019901]; protein tyrosine kinase activator activity [GO:0030296]	cell surface [GO:0009986]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; protein kinase binding [GO:0019901]; protein tyrosine kinase activator activity [GO:0030296]; B cell receptor transport into membrane raft [GO:0032597]; cell activation [GO:0001775]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; chemokine receptor transport out of membrane raft [GO:0032600]; cholesterol homeostasis [GO:0042632]; glomerular parietal epithelial cell differentiation [GO:0072139]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of transforming growth factor beta3 production [GO:0032913]; podocyte differentiation [GO:0072112]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; regulation of cytokine-mediated signaling pathway [GO:0001959]; regulation of epithelial cell differentiation [GO:0030856]; regulation of MAPK cascade [GO:0043408]; regulation of phosphorylation [GO:0042325]; respiratory burst [GO:0045730]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to molecule of bacterial origin [GO:0002237]; T cell costimulation [GO:0031295]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
P25067	reviewed	CO8A2_HUMAN	Collagen alpha-2(VIII) chain (Endothelial collagen)	COL8A2	Homo sapiens (Human)	703	FUNCTION: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). {ECO:0000250}.		angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; cell-cell adhesion [GO:0098609]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198]	basement membrane [GO:0005604]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674]	basement membrane [GO:0005604]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674]; angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; cell-cell adhesion [GO:0098609]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
P25090	reviewed	FPR2_HUMAN	N-formyl peptide receptor 2 (FMLP-related receptor I) (FMLP-R-I) (Formyl peptide receptor-like 1) (HM63) (Lipoxin A4 receptor) (LXA4 receptor) (RFP)	FPR2 FPRH1 FPRL1 LXA4R	Homo sapiens (Human)	351	FUNCTION: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity). Acts as a receptor for humanin (PubMed:15465011). {ECO:0000250|UniProtKB:O88536, ECO:0000269|PubMed:1374236, ECO:0000269|PubMed:15465011, ECO:0000269|PubMed:9547339}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; astrocyte activation [GO:0048143]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; defense response to bacterium [GO:0042742]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; inflammatory response [GO:0006954]; microglial cell activation [GO:0001774]; negative regulation of inflammatory response [GO:0050728]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive chemotaxis [GO:0050918]; positive regulation of 1-phosphatidylinositol-3-kinase activity [GO:0061903]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of innate immune response [GO:0045089]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of superoxide anion generation [GO:0032930]; receptor-mediated endocytosis [GO:0006898]	cytoplasm [GO:0005737]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; N-formyl peptide receptor activity [GO:0004982]; scavenger receptor binding [GO:0005124]; signaling receptor activity [GO:0038023]	cytoplasm [GO:0005737]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; N-formyl peptide receptor activity [GO:0004982]; scavenger receptor binding [GO:0005124]; signaling receptor activity [GO:0038023]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; astrocyte activation [GO:0048143]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; defense response to bacterium [GO:0042742]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; inflammatory response [GO:0006954]; microglial cell activation [GO:0001774]; negative regulation of inflammatory response [GO:0050728]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive chemotaxis [GO:0050918]; positive regulation of 1-phosphatidylinositol-3-kinase activity [GO:0061903]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of innate immune response [GO:0045089]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of superoxide anion generation [GO:0032930]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11689470, ECO:0000269|PubMed:15465011}; Multi-pass membrane protein. Note=Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470). Also internalized in the presence of humanin (PubMed:15465011). {ECO:0000269|PubMed:11689470, ECO:0000269|PubMed:15465011}.
P25092	reviewed	GUC2C_HUMAN	Guanylyl cyclase C (GC-C) (EC 4.6.1.2) (Heat-stable enterotoxin receptor) (STA receptor) (hSTAR) (Intestinal guanylate cyclase)	GUCY2C GUC2C STAR	Homo sapiens (Human)	1073	FUNCTION: Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:1718270, PubMed:11950846, PubMed:23269669, PubMed:22521417, PubMed:22436048). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1718270, PubMed:1680854). Also activated by the endogenous peptides guanylin and uroguanylin (PubMed:8381596). {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:1680854, ECO:0000269|PubMed:1718270, ECO:0000269|PubMed:22436048, ECO:0000269|PubMed:22521417, ECO:0000269|PubMed:23269669, ECO:0000269|PubMed:8381596}.		cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of cell population proliferation [GO:0042127]; response to toxic substance [GO:0009636]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]; toxic substance binding [GO:0015643]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]; toxic substance binding [GO:0015643]; cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of cell population proliferation [GO:0042127]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23269669}; Single-pass type I membrane protein {ECO:0000269|PubMed:23269669}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23269669}; Single-pass type I membrane protein {ECO:0000269|PubMed:23269669}. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form. {ECO:0000269|PubMed:23269669}.
P25098	reviewed	ARBK1_HUMAN	Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)	GRK2 ADRBK1 BARK BARK1	Homo sapiens (Human)	689	FUNCTION: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927). {ECO:0000250|UniProtKB:P21146, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19715378, ECO:0000269|PubMed:30284927}.		cardiac muscle contraction [GO:0060048]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; negative regulation of relaxation of smooth muscle [GO:1901081]; negative regulation of striated muscle contraction [GO:0045988]; negative regulation of the force of heart contraction by chemical signal [GO:0003108]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of catecholamine secretion [GO:0033605]; receptor internalization [GO:0031623]; regulation of the force of heart contraction [GO:0002026]; tachykinin receptor signaling pathway [GO:0007217]; viral entry into host cell [GO:0046718]; viral genome replication [GO:0019079]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]	alpha-2A adrenergic receptor binding [GO:0031694]; ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled receptor kinase activity [GO:0004703]; protein kinase activity [GO:0004672]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; alpha-2A adrenergic receptor binding [GO:0031694]; ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled receptor kinase activity [GO:0004703]; protein kinase activity [GO:0004672]; cardiac muscle contraction [GO:0060048]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; negative regulation of relaxation of smooth muscle [GO:1901081]; negative regulation of striated muscle contraction [GO:0045988]; negative regulation of the force of heart contraction by chemical signal [GO:0003108]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of catecholamine secretion [GO:0033605]; receptor internalization [GO:0031623]; regulation of the force of heart contraction [GO:0002026]; tachykinin receptor signaling pathway [GO:0007217]; viral entry into host cell [GO:0046718]; viral genome replication [GO:0019079]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P26817}. Cell membrane {ECO:0000250|UniProtKB:P21146}. Postsynapse {ECO:0000250|UniProtKB:P26817}. Presynapse {ECO:0000250|UniProtKB:P26817}.
P25100	reviewed	ADA1D_HUMAN	Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a)	ADRA1D ADRA1A	Homo sapiens (Human)	572	FUNCTION: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.		adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; neuron-glial cell signaling [GO:0150099]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of vasoconstriction [GO:0045907]	plasma membrane [GO:0005886]	alpha1-adrenergic receptor activity [GO:0004937]; identical protein binding [GO:0042802]	plasma membrane [GO:0005886]; alpha1-adrenergic receptor activity [GO:0004937]; identical protein binding [GO:0042802]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; neuron-glial cell signaling [GO:0150099]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of vasoconstriction [GO:0045907]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P25101	reviewed	EDNRA_HUMAN	Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR)	EDNRA ETA ETRA	Homo sapiens (Human)	427	FUNCTION: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.		activation of adenylate cyclase activity [GO:0007190]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; aorta development [GO:0035904]; artery smooth muscle contraction [GO:0014824]; atrial cardiac muscle tissue development [GO:0003228]; axon extension [GO:0048675]; axonogenesis involved in innervation [GO:0060385]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; calcium ion transmembrane transport [GO:0070588]; canonical NF-kappaB signal transduction [GO:0007249]; canonical Wnt signaling pathway [GO:0060070]; cardiac chamber formation [GO:0003207]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell population proliferation [GO:0008283]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to human chorionic gonadotropin stimulus [GO:0044751]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to oxidative stress [GO:0034599]; cranial skeletal system development [GO:1904888]; developmental pigmentation [GO:0048066]; embryonic heart tube development [GO:0035050]; embryonic skeletal system development [GO:0048706]; endothelin receptor signaling pathway [GO:0086100]; endothelin receptor signaling pathway involved in heart process [GO:0086101]; enteric nervous system development [GO:0048484]; establishment of endothelial barrier [GO:0061028]; face development [GO:0060324]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; glomerular endothelium development [GO:0072011]; glomerular filtration [GO:0003094]; heparin metabolic process [GO:0030202]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; mesenchymal cell apoptotic process [GO:0097152]; middle ear morphogenesis [GO:0042474]; mitochondrion organization [GO:0007005]; mitotic cell cycle [GO:0000278]; neural crest cell fate commitment [GO:0014034]; neuromuscular process [GO:0050905]; neuron remodeling [GO:0016322]; noradrenergic neuron differentiation [GO:0003357]; norepinephrine metabolic process [GO:0042415]; pharyngeal arch artery morphogenesis [GO:0061626]; podocyte apoptotic process [GO:1903210]; podocyte differentiation [GO:0072112]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein kinase A signaling [GO:0010737]; protein transmembrane transport [GO:0071806]; regulation of blood pressure [GO:0008217]; regulation of glucose transmembrane transport [GO:0010827]; regulation of heart rate [GO:0002027]; regulation of protein localization to cell leading edge [GO:1905871]; renal albumin absorption [GO:0097018]; renal sodium ion absorption [GO:0070294]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to acetylcholine [GO:1905144]; response to amphetamine [GO:0001975]; response to hypoxia [GO:0001666]; response to wounding [GO:0009611]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]; sodium ion homeostasis [GO:0055078]; sympathetic nervous system development [GO:0048485]; sympathetic neuron axon guidance [GO:0097492]; thyroid gland development [GO:0030878]; vascular associated smooth muscle cell development [GO:0097084]; vasoconstriction [GO:0042310]	plasma membrane [GO:0005886]	endothelin receptor activity [GO:0004962]; phosphatidylinositol phospholipase C activity [GO:0004435]	plasma membrane [GO:0005886]; endothelin receptor activity [GO:0004962]; phosphatidylinositol phospholipase C activity [GO:0004435]; activation of adenylate cyclase activity [GO:0007190]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; aorta development [GO:0035904]; artery smooth muscle contraction [GO:0014824]; atrial cardiac muscle tissue development [GO:0003228]; axon extension [GO:0048675]; axonogenesis involved in innervation [GO:0060385]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; calcium ion transmembrane transport [GO:0070588]; canonical NF-kappaB signal transduction [GO:0007249]; canonical Wnt signaling pathway [GO:0060070]; cardiac chamber formation [GO:0003207]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell population proliferation [GO:0008283]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to human chorionic gonadotropin stimulus [GO:0044751]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to oxidative stress [GO:0034599]; cranial skeletal system development [GO:1904888]; developmental pigmentation [GO:0048066]; embryonic heart tube development [GO:0035050]; embryonic skeletal system development [GO:0048706]; endothelin receptor signaling pathway [GO:0086100]; endothelin receptor signaling pathway involved in heart process [GO:0086101]; enteric nervous system development [GO:0048484]; establishment of endothelial barrier [GO:0061028]; face development [GO:0060324]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; glomerular endothelium development [GO:0072011]; glomerular filtration [GO:0003094]; heparin metabolic process [GO:0030202]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; mesenchymal cell apoptotic process [GO:0097152]; middle ear morphogenesis [GO:0042474]; mitochondrion organization [GO:0007005]; mitotic cell cycle [GO:0000278]; neural crest cell fate commitment [GO:0014034]; neuromuscular process [GO:0050905]; neuron remodeling [GO:0016322]; noradrenergic neuron differentiation [GO:0003357]; norepinephrine metabolic process [GO:0042415]; pharyngeal arch artery morphogenesis [GO:0061626]; podocyte apoptotic process [GO:1903210]; podocyte differentiation [GO:0072112]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein kinase A signaling [GO:0010737]; protein transmembrane transport [GO:0071806]; regulation of blood pressure [GO:0008217]; regulation of glucose transmembrane transport [GO:0010827]; regulation of heart rate [GO:0002027]; regulation of protein localization to cell leading edge [GO:1905871]; renal albumin absorption [GO:0097018]; renal sodium ion absorption [GO:0070294]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to acetylcholine [GO:1905144]; response to amphetamine [GO:0001975]; response to hypoxia [GO:0001666]; response to wounding [GO:0009611]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]; sodium ion homeostasis [GO:0055078]; sympathetic nervous system development [GO:0048485]; sympathetic neuron axon guidance [GO:0097492]; thyroid gland development [GO:0030878]; vascular associated smooth muscle cell development [GO:0097084]; vasoconstriction [GO:0042310]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P25103	reviewed	NK1R_HUMAN	Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1)	TACR1 NK1R TAC1R	Homo sapiens (Human)	407	FUNCTION: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.	MISCELLANEOUS: [Isoform 2]: In contrast to Fong et al. data (PubMed:1310144), isoform 2 is not detected by PCR in any of 24 human tissues examined including the placenta (PubMed:11864635). {ECO:0000305|PubMed:11864635, ECO:0000305|PubMed:1310144}.	aggressive behavior [GO:0002118]; angiotensin-mediated drinking behavior [GO:0003051]; associative learning [GO:0008306]; behavioral response to pain [GO:0048266]; detection of abiotic stimulus [GO:0009582]; eating behavior [GO:0042755]; inflammatory response [GO:0006954]; long-term memory [GO:0007616]; operant conditioning [GO:0035106]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of action potential [GO:0045760]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of hormone secretion [GO:0046887]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of ossification [GO:0045778]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of uterine smooth muscle contraction [GO:0070474]; positive regulation of vascular permeability [GO:0043117]; positive regulation of vasoconstriction [GO:0045907]; regulation of smooth muscle cell migration [GO:0014910]; regulation of smooth muscle cell proliferation [GO:0048660]; response to auditory stimulus [GO:0010996]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to nicotine [GO:0035094]; response to ozone [GO:0010193]; response to progesterone [GO:0032570]; smooth muscle contraction involved in micturition [GO:0060083]; sperm ejaculation [GO:0042713]; tachykinin receptor signaling pathway [GO:0007217]	cell body [GO:0044297]; cell surface [GO:0009986]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; sperm midpiece [GO:0097225]	substance P receptor activity [GO:0016496]; tachykinin receptor activity [GO:0004995]	cell body [GO:0044297]; cell surface [GO:0009986]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; sperm midpiece [GO:0097225]; substance P receptor activity [GO:0016496]; tachykinin receptor activity [GO:0004995]; aggressive behavior [GO:0002118]; angiotensin-mediated drinking behavior [GO:0003051]; associative learning [GO:0008306]; behavioral response to pain [GO:0048266]; detection of abiotic stimulus [GO:0009582]; eating behavior [GO:0042755]; inflammatory response [GO:0006954]; long-term memory [GO:0007616]; operant conditioning [GO:0035106]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of action potential [GO:0045760]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of hormone secretion [GO:0046887]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of ossification [GO:0045778]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of uterine smooth muscle contraction [GO:0070474]; positive regulation of vascular permeability [GO:0043117]; positive regulation of vasoconstriction [GO:0045907]; regulation of smooth muscle cell migration [GO:0014910]; regulation of smooth muscle cell proliferation [GO:0048660]; response to auditory stimulus [GO:0010996]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to nicotine [GO:0035094]; response to ozone [GO:0010193]; response to progesterone [GO:0032570]; smooth muscle contraction involved in micturition [GO:0060083]; sperm ejaculation [GO:0042713]; tachykinin receptor signaling pathway [GO:0007217]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P25105	reviewed	PTAFR_HUMAN	Platelet-activating factor receptor (PAF-R) (PAFr)	PTAFR PAFR	Homo sapiens (Human)	342	FUNCTION: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:1281995, ECO:0000269|PubMed:1374385, ECO:0000269|PubMed:1656963, ECO:0000269|PubMed:1657923}.		cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine [GO:1904317]; cellular response to cAMP [GO:0071320]; cellular response to fatty acid [GO:0071398]; cellular response to gravity [GO:0071258]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; inositol trisphosphate biosynthetic process [GO:0032959]; negative regulation of blood pressure [GO:0045776]; parturition [GO:0007567]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of gastro-intestinal system smooth muscle contraction [GO:1904306]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of maternal process involved in parturition [GO:1904303]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcytosis [GO:1904300]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of transcription by RNA polymerase II [GO:0006357]; response to dexamethasone [GO:0071548]; response to symbiotic bacterium [GO:0009609]; transcytosis [GO:0045056]	membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]	G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; mitogen-activated protein kinase binding [GO:0051019]; phospholipid binding [GO:0005543]; platelet activating factor receptor activity [GO:0004992]	membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; mitogen-activated protein kinase binding [GO:0051019]; phospholipid binding [GO:0005543]; platelet activating factor receptor activity [GO:0004992]; cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine [GO:1904317]; cellular response to cAMP [GO:0071320]; cellular response to fatty acid [GO:0071398]; cellular response to gravity [GO:0071258]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; inositol trisphosphate biosynthetic process [GO:0032959]; negative regulation of blood pressure [GO:0045776]; parturition [GO:0007567]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of gastro-intestinal system smooth muscle contraction [GO:1904306]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of maternal process involved in parturition [GO:1904303]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcytosis [GO:1904300]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of transcription by RNA polymerase II [GO:0006357]; response to dexamethasone [GO:0071548]; response to symbiotic bacterium [GO:0009609]; transcytosis [GO:0045056]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1374385}; Multi-pass membrane protein {ECO:0000269|PubMed:1374385}.
P25106	reviewed	ACKR3_HUMAN	Atypical chemokine receptor 3 (C-X-C chemokine receptor type 7) (CXC-R7) (CXCR-7) (Chemokine orphan receptor 1) (G-protein coupled receptor 159) (G-protein coupled receptor RDC1 homolog) (RDC-1)	ACKR3 CMKOR1 CXCR7 GPR159 RDC1	Homo sapiens (Human)	362	FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1 (PubMed:16107333, PubMed:19255243, PubMed:19380869, PubMed:20161793, PubMed:22300987). Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway (PubMed:16940167, PubMed:18653785, PubMed:20018651). Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness (PubMed:16940167, PubMed:18653785). In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival (PubMed:16940167, PubMed:20388803). Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration (PubMed:17804806, PubMed:18653785, PubMed:19641136, PubMed:20887389). Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12 (PubMed:18653785). Required for heart valve development (PubMed:17804806). Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels (PubMed:31211835). {ECO:0000269|PubMed:16107333, ECO:0000269|PubMed:16940167, ECO:0000269|PubMed:17804806, ECO:0000269|PubMed:18653785, ECO:0000269|PubMed:19255243, ECO:0000269|PubMed:19380869, ECO:0000269|PubMed:19641136, ECO:0000269|PubMed:20018651, ECO:0000269|PubMed:20161793, ECO:0000269|PubMed:20388803, ECO:0000269|PubMed:20887389, ECO:0000269|PubMed:22300987, ECO:0000269|PubMed:31211835}.; FUNCTION: (Microbial infection) Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. {ECO:0000305|PubMed:23153575}.		angiogenesis [GO:0001525]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; chemokine-mediated signaling pathway [GO:0070098]; immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; oculomotor nerve development [GO:0021557]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of mesenchymal stem cell migration [GO:1905322]; receptor internalization [GO:0031623]; vasculogenesis [GO:0001570]	cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine binding [GO:0019958]; C-X-C chemokine receptor activity [GO:0016494]; coreceptor activity [GO:0015026]; scavenger receptor activity [GO:0005044]	cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine binding [GO:0019958]; C-X-C chemokine receptor activity [GO:0016494]; coreceptor activity [GO:0015026]; scavenger receptor activity [GO:0005044]; angiogenesis [GO:0001525]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; chemokine-mediated signaling pathway [GO:0070098]; immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; oculomotor nerve development [GO:0021557]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of mesenchymal stem cell migration [GO:1905322]; receptor internalization [GO:0031623]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31211835}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:22457824}. Recycling endosome {ECO:0000269|PubMed:22457824}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits in a beta-arrestin-dependent manner. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. {ECO:0000269|PubMed:22457824}.
P25116	reviewed	PAR1_HUMAN	Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)	F2R CF2R PAR1 TR	Homo sapiens (Human)	425	FUNCTION: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. {ECO:0000269|PubMed:10079109}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; anatomical structure morphogenesis [GO:0009653]; cell-cell junction maintenance [GO:0045217]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; dendritic cell homeostasis [GO:0036145]; establishment of synaptic specificity at neuromuscular junction [GO:0007529]; G protein-coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of glomerular filtration [GO:0003105]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of renin secretion into blood stream [GO:1900134]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of blood coagulation [GO:0030194]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of vasoconstriction [GO:0045907]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of blood coagulation [GO:0030193]; regulation of interleukin-1 beta production [GO:0032651]; regulation of sensory perception of pain [GO:0051930]; release of sequestered calcium ion into cytosol [GO:0051209]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553]	caveola [GO:0005901]; cell surface [GO:0009986]; early endosome [GO:0005769]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; platelet dense tubular network [GO:0031094]; postsynaptic membrane [GO:0045211]	G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; signaling receptor binding [GO:0005102]; thrombin-activated receptor activity [GO:0015057]	caveola [GO:0005901]; cell surface [GO:0009986]; early endosome [GO:0005769]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; platelet dense tubular network [GO:0031094]; postsynaptic membrane [GO:0045211]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; signaling receptor binding [GO:0005102]; thrombin-activated receptor activity [GO:0015057]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; anatomical structure morphogenesis [GO:0009653]; cell-cell junction maintenance [GO:0045217]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; dendritic cell homeostasis [GO:0036145]; establishment of synaptic specificity at neuromuscular junction [GO:0007529]; G protein-coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of glomerular filtration [GO:0003105]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of renin secretion into blood stream [GO:1900134]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of blood coagulation [GO:0030194]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of vasoconstriction [GO:0045907]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of blood coagulation [GO:0030193]; regulation of interleukin-1 beta production [GO:0032651]; regulation of sensory perception of pain [GO:0051930]; release of sequestered calcium ion into cytosol [GO:0051209]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P25189	reviewed	MYP0_HUMAN	Myelin protein P0 (Myelin peripheral protein) (MPP) (Myelin protein zero)	MPZ	Homo sapiens (Human)	248	FUNCTION: Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. {ECO:0000269|PubMed:10545037, ECO:0000269|PubMed:18337304}.	MISCELLANEOUS: [Isoform L-MPZ]: Based on a naturally occurring readthrough transcript. Highly antigenic. {ECO:0000305}.	cell aggregation [GO:0098743]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; chemical synaptic transmission [GO:0007268]; myelination [GO:0042552]	myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; synapse [GO:0045202]	structural molecule activity [GO:0005198]	myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; synapse [GO:0045202]; structural molecule activity [GO:0005198]; cell aggregation [GO:0098743]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; chemical synaptic transmission [GO:0007268]; myelination [GO:0042552]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18337304}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform L-MPZ]: Myelin membrane {ECO:0000269|PubMed:22457349}; Single-pass type I membrane protein {ECO:0000269|PubMed:22457349}.
P25205	reviewed	MCM3_HUMAN	DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)	MCM3	Homo sapiens (Human)	808	FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}.	MISCELLANEOUS: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex.	DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; regulation of DNA-templated DNA replication initiation [GO:0030174]	alpha DNA polymerase:primase complex [GO:0005658]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; single-stranded DNA binding [GO:0003697]	alpha DNA polymerase:primase complex [GO:0005658]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; single-stranded DNA binding [GO:0003697]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; regulation of DNA-templated DNA replication initiation [GO:0030174]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000305|PubMed:35585232}.
P25208	reviewed	NFYB_HUMAN	Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB)	NFYB HAP3	Homo sapiens (Human)	207	FUNCTION: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.		cellular response to leukemia inhibitory factor [GO:1990830]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of histone acetylation [GO:0035065]; regulation of transcription by RNA polymerase II [GO:0006357]	CCAAT-binding factor complex [GO:0016602]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	CCAAT-binding factor complex [GO:0016602]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cellular response to leukemia inhibitory factor [GO:1990830]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of histone acetylation [GO:0035065]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P25311	reviewed	ZA2G_HUMAN	Zinc-alpha-2-glycoprotein (Zn-alpha-2-GP) (Zn-alpha-2-glycoprotein)	AZGP1 ZAG ZNGP1	Homo sapiens (Human)	298	FUNCTION: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.		cell adhesion [GO:0007155]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; retina homeostasis [GO:0001895]	collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]	protein transmembrane transporter activity [GO:0008320]; RNA nuclease activity [GO:0004540]	collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; protein transmembrane transporter activity [GO:0008320]; RNA nuclease activity [GO:0004540]; cell adhesion [GO:0007155]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Secreted.
P25325	reviewed	THTM_HUMAN	3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2)	MPST TST2	Homo sapiens (Human)	297	FUNCTION: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions. {ECO:0000250|UniProtKB:P97532}.	MISCELLANEOUS: Thioredoxin (Trx) or dihydrolipoic acid (DHLA) are required to release hydrogen sulfide from the persulfide intermediate. {ECO:0000250|UniProtKB:Q99J99}.	cyanate catabolic process [GO:0009440]; hydrogen sulfide biosynthetic process [GO:0070814]; kidney development [GO:0001822]; liver development [GO:0001889]; response to toxic substance [GO:0009636]; spinal cord development [GO:0021510]; sulfur amino acid catabolic process [GO:0000098]; transsulfuration [GO:0019346]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; synapse [GO:0045202]	3-mercaptopyruvate sulfurtransferase activity [GO:0016784]; identical protein binding [GO:0042802]; thiosulfate sulfurtransferase activity [GO:0004792]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; synapse [GO:0045202]; 3-mercaptopyruvate sulfurtransferase activity [GO:0016784]; identical protein binding [GO:0042802]; thiosulfate sulfurtransferase activity [GO:0004792]; cyanate catabolic process [GO:0009440]; hydrogen sulfide biosynthetic process [GO:0070814]; kidney development [GO:0001822]; liver development [GO:0001889]; response to toxic substance [GO:0009636]; spinal cord development [GO:0021510]; sulfur amino acid catabolic process [GO:0000098]; transsulfuration [GO:0019346]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P97532}. Mitochondrion {ECO:0000250|UniProtKB:P97532}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q99J99}.
P25391	reviewed	LAMA1_HUMAN	Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha)	LAMA1 LAMA	Homo sapiens (Human)	3075	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.		branching involved in salivary gland morphogenesis [GO:0060445]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of epithelial cell apical/basal polarity [GO:0045198]; morphogenesis of an epithelial sheet [GO:0002011]; neuron projection development [GO:0031175]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; retinal blood vessel morphogenesis [GO:0061304]	basement membrane [GO:0005604]; cell-cell junction [GO:0005911]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-1 complex [GO:0005606]; laminin-3 complex [GO:0005608]; membrane [GO:0016020]; protein complex involved in cell-matrix adhesion [GO:0098637]	extracellular matrix structural constituent [GO:0005201]; glycosphingolipid binding [GO:0043208]; signaling receptor binding [GO:0005102]	basement membrane [GO:0005604]; cell-cell junction [GO:0005911]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-1 complex [GO:0005606]; laminin-3 complex [GO:0005608]; membrane [GO:0016020]; protein complex involved in cell-matrix adhesion [GO:0098637]; extracellular matrix structural constituent [GO:0005201]; glycosphingolipid binding [GO:0043208]; signaling receptor binding [GO:0005102]; branching involved in salivary gland morphogenesis [GO:0060445]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of epithelial cell apical/basal polarity [GO:0045198]; morphogenesis of an epithelial sheet [GO:0002011]; neuron projection development [GO:0031175]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; retinal blood vessel morphogenesis [GO:0061304]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
P25398	reviewed	RS12_HUMAN	Small ribosomal subunit protein eS12 (40S ribosomal protein S12)	RPS12	Homo sapiens (Human)	132	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Subunit of the 40S ribosomal complex (By similarity). {ECO:0000250|UniProtKB:P80455, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
P25440	reviewed	BRD2_HUMAN	Bromodomain-containing protein 2 (O27.1.1) (Really interesting new gene 3 protein)	BRD2 KIAA9001 RING3	Homo sapiens (Human)	801	FUNCTION: May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. {ECO:0000250, ECO:0000269|PubMed:18406326}.		neural tube closure [GO:0001843]; nucleosome assembly [GO:0006334]; protein phosphorylation [GO:0006468]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; lysine-acetylated histone binding [GO:0070577]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; lysine-acetylated histone binding [GO:0070577]; protein serine/threonine kinase activity [GO:0004674]; neural tube closure [GO:0001843]; nucleosome assembly [GO:0006334]; protein phosphorylation [GO:0006468]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:25593309}. Note=Detected on chromatin and nucleosomes. {ECO:0000269|PubMed:18406326}.
P25445	reviewed	TNR6_HUMAN	Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)	FAS APT1 FAS1 TNFRSF6	Homo sapiens (Human)	335	FUNCTION: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Dominant negative isoform, resistant to Fas-mediated apoptosis. {ECO:0000305}.	activation-induced cell death of T cells [GO:0006924]; apoptotic process [GO:0006915]; cellular response to amino acid starvation [GO:0034198]; cellular response to hyperoxia [GO:0071455]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; Fas signaling pathway [GO:0036337]; immune response [GO:0006955]; motor neuron apoptotic process [GO:0097049]; necroptotic signaling pathway [GO:0097527]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of protein phosphorylation [GO:0001934]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of stress-activated MAPK cascade [GO:0032872]; signal transduction [GO:0007165]	CD95 death-inducing signaling complex [GO:0031265]; cell surface [GO:0009986]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; signaling receptor activity [GO:0038023]; tumor necrosis factor receptor activity [GO:0005031]	CD95 death-inducing signaling complex [GO:0031265]; cell surface [GO:0009986]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; signaling receptor activity [GO:0038023]; tumor necrosis factor receptor activity [GO:0005031]; activation-induced cell death of T cells [GO:0006924]; apoptotic process [GO:0006915]; cellular response to amino acid starvation [GO:0034198]; cellular response to hyperoxia [GO:0071455]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; Fas signaling pathway [GO:0036337]; immune response [GO:0006955]; motor neuron apoptotic process [GO:0097049]; necroptotic signaling pathway [GO:0097527]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of protein phosphorylation [GO:0001934]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of stress-activated MAPK cascade [GO:0032872]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:1713127, ECO:0000269|PubMed:25301068}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:25301068}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted.
P25490	reviewed	TYY1_HUMAN	Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1)	YY1 INO80S	Homo sapiens (Human)	414	FUNCTION: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence (PubMed:1655281). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed (PubMed:11158321). Involved in DNA repair (PubMed:18026119, PubMed:28575647). In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). {ECO:0000269|PubMed:11158321, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:1655281, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:24326773, ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119}.		anterior/posterior pattern specification [GO:0009952]; B cell differentiation [GO:0030183]; camera-type eye morphogenesis [GO:0048593]; cellular response to interleukin-1 [GO:0071347]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; immunoglobulin heavy chain V-D-J recombination [GO:0071707]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of gene expression [GO:0010629]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; response to prostaglandin F [GO:0034696]; response to UV-C [GO:0010225]; RNA localization [GO:0006403]; spermatogenesis [GO:0007283]; telomere maintenance [GO:0000723]	chromatin silencing complex [GO:0005677]; Ino80 complex [GO:0031011]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; four-way junction DNA binding [GO:0000400]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]	chromatin silencing complex [GO:0005677]; Ino80 complex [GO:0031011]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; four-way junction DNA binding [GO:0000400]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]; anterior/posterior pattern specification [GO:0009952]; B cell differentiation [GO:0030183]; camera-type eye morphogenesis [GO:0048593]; cellular response to interleukin-1 [GO:0071347]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; immunoglobulin heavy chain V-D-J recombination [GO:0071707]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of gene expression [GO:0010629]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; response to prostaglandin F [GO:0034696]; response to UV-C [GO:0010225]; RNA localization [GO:0006403]; spermatogenesis [GO:0007283]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:23385818, ECO:0000269|PubMed:9493912}. Note=Associated with the nuclear matrix. {ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:23385818, ECO:0000269|PubMed:9493912}.
P25685	reviewed	DNJB1_HUMAN	DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1)	DNAJB1 DNAJ1 HDJ1 HSPF1	Homo sapiens (Human)	340	FUNCTION: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}.		cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0051085]; forebrain development [GO:0030900]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of cellular response to heat [GO:1900034]; response to unfolded protein [GO:0006986]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; sperm head [GO:0061827]	ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; sperm head [GO:0061827]; ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; unfolded protein binding [GO:0051082]; cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0051085]; forebrain development [GO:0030900]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of cellular response to heat [GO:1900034]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1586970}. Nucleus {ECO:0000269|PubMed:1586970}. Nucleus, nucleolus {ECO:0000269|PubMed:1586970}. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.
P25686	reviewed	DNJB2_HUMAN	DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1)	DNAJB2 HSJ1 HSPF3	Homo sapiens (Human)	324	FUNCTION: Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). {ECO:0000269|PubMed:12754272, ECO:0000269|PubMed:15936278, ECO:0000269|PubMed:20889486, ECO:0000269|PubMed:21625540, ECO:0000269|PubMed:21719532, ECO:0000269|PubMed:22219199, ECO:0000269|PubMed:22396390, ECO:0000269|PubMed:24023695, ECO:0000269|PubMed:7957263}.		chaperone-mediated protein folding [GO:0061077]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of protein binding [GO:0032091]; negative regulation of protein deubiquitination [GO:0090086]; neuron cellular homeostasis [GO:0070050]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein refolding [GO:0042026]; regulation of chaperone-mediated protein folding [GO:1903644]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; inclusion body [GO:0016234]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATPase activator activity [GO:0001671]; Hsp70 protein binding [GO:0030544]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-dependent protein binding [GO:0140036]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; inclusion body [GO:0016234]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATPase activator activity [GO:0001671]; Hsp70 protein binding [GO:0030544]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-dependent protein binding [GO:0140036]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of protein binding [GO:0032091]; negative regulation of protein deubiquitination [GO:0090086]; neuron cellular homeostasis [GO:0070050]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein refolding [GO:0042026]; regulation of chaperone-mediated protein folding [GO:1903644]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:12754272, ECO:0000269|PubMed:21625540}. Nucleus {ECO:0000269|PubMed:12754272}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12754272}; Lipid-anchor {ECO:0000269|PubMed:12754272}; Cytoplasmic side {ECO:0000269|PubMed:12754272}.
P25705	reviewed	ATPA_HUMAN	ATP synthase subunit alpha, mitochondrial (ATP synthase F1 subunit alpha)	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	Homo sapiens (Human)	553	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159}.	MISCELLANEOUS: The siderophore enterobactin (Ent) produced by enteric bacteria binds Fe(3+) and helps bacteria scavenge iron ions from the environment (PubMed:30146159). As a consequence, the mammalian siderocalin LCN2 plays an important role in defense against bacterial infections by sequestering iron bound to microbial siderophores. LCN2 can also bind iron bound to endogenous or nutrient-derived iron chelators and plays an important role in cellular iron homeostasis. Enterobactin produced by non-pathogenic E.coli strains can facilitate mitochondrial iron assimilation, suggesting that iron bound to siderophores from non-pathogenic bacteria may contribute to iron absorption by the host (PubMed:30146159). {ECO:0000269|PubMed:30146159, ECO:0000305}.	ATP biosynthetic process [GO:0006754]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to nitric oxide [GO:0071732]; lipid metabolic process [GO:0006629]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to ethanol [GO:0045471]; response to muscle activity [GO:0014850]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, catalytic core [GO:0005754]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]	ADP binding [GO:0043531]; angiostatin binding [GO:0043532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; MHC class I protein binding [GO:0042288]; protease binding [GO:0002020]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; RNA binding [GO:0003723]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, catalytic core [GO:0005754]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; ADP binding [GO:0043531]; angiostatin binding [GO:0043532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; MHC class I protein binding [GO:0042288]; protease binding [GO:0002020]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; RNA binding [GO:0003723]; ATP biosynthetic process [GO:0006754]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to nitric oxide [GO:0071732]; lipid metabolic process [GO:0006629]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to ethanol [GO:0045471]; response to muscle activity [GO:0014850]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:30146159}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P19483}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19483}; Matrix side {ECO:0000250|UniProtKB:P19483}. Cell membrane {ECO:0000269|PubMed:10077593}; Peripheral membrane protein {ECO:0000269|PubMed:10077593}; Extracellular side {ECO:0000269|PubMed:10077593}. Note=Colocalizes with HRG on the cell surface of T-cells (PubMed:19285951). {ECO:0000269|PubMed:19285951}.
P25713	reviewed	MT3_HUMAN	Metallothionein-3 (MT-3) (GIFB) (GIF) (Growth inhibitory factor) (Metallothionein-III) (MT-III)	MT3	Homo sapiens (Human)	68	FUNCTION: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.		activation of protein kinase B activity [GO:0032148]; cellular detoxification [GO:1990748]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; energy reserve metabolic process [GO:0006112]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; leptin-mediated signaling pathway [GO:0033210]; negative regulation of axon extension [GO:0030517]; negative regulation of cell growth [GO:0030308]; negative regulation of hydrogen peroxide catabolic process [GO:2000296]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oxidoreductase activity [GO:0051354]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of oxygen metabolic process [GO:2000376]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein stabilization [GO:0050821]; regulation of response to food [GO:0032095]; removal of superoxide radicals [GO:0019430]; response to hypoxia [GO:0001666]; zinc ion transport [GO:0006829]	astrocyte end-foot [GO:0097450]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular space [GO:0005615]; inclusion body [GO:0016234]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]; synaptic vesicle [GO:0008021]	antioxidant activity [GO:0016209]; cadmium ion binding [GO:0046870]; copper ion binding [GO:0005507]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; zinc ion binding [GO:0008270]	astrocyte end-foot [GO:0097450]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular space [GO:0005615]; inclusion body [GO:0016234]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]; synaptic vesicle [GO:0008021]; antioxidant activity [GO:0016209]; cadmium ion binding [GO:0046870]; copper ion binding [GO:0005507]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; zinc ion binding [GO:0008270]; activation of protein kinase B activity [GO:0032148]; cellular detoxification [GO:1990748]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; energy reserve metabolic process [GO:0006112]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; leptin-mediated signaling pathway [GO:0033210]; negative regulation of axon extension [GO:0030517]; negative regulation of cell growth [GO:0030308]; negative regulation of hydrogen peroxide catabolic process [GO:2000296]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oxidoreductase activity [GO:0051354]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of oxygen metabolic process [GO:2000376]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein stabilization [GO:0050821]; regulation of response to food [GO:0032095]; removal of superoxide radicals [GO:0019430]; response to hypoxia [GO:0001666]; zinc ion transport [GO:0006829]	
P25774	reviewed	CATS_HUMAN	Cathepsin S (EC 3.4.22.27)	CTSS	Homo sapiens (Human)	331	FUNCTION: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. {ECO:0000269|PubMed:30612035}.		adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen [GO:0048002]; basement membrane disassembly [GO:0034769]; cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cation channel activity [GO:2001259]; protein processing [GO:0016485]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to acidic pH [GO:0010447]; toll-like receptor signaling pathway [GO:0002224]	collagen-containing extracellular matrix [GO:0062023]; endolysosome lumen [GO:0036021]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; tertiary granule lumen [GO:1904724]	collagen binding [GO:0005518]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; proteoglycan binding [GO:0043394]; serine-type endopeptidase activity [GO:0004252]	collagen-containing extracellular matrix [GO:0062023]; endolysosome lumen [GO:0036021]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; tertiary granule lumen [GO:1904724]; collagen binding [GO:0005518]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; proteoglycan binding [GO:0043394]; serine-type endopeptidase activity [GO:0004252]; adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen [GO:0048002]; basement membrane disassembly [GO:0034769]; cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cation channel activity [GO:2001259]; protein processing [GO:0016485]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to acidic pH [GO:0010447]; toll-like receptor signaling pathway [GO:0002224]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:1377692}. Secreted {ECO:0000269|PubMed:9524075}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:30612035}.
P25786	reviewed	PSA1_HUMAN	Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)	PSMA1 HC2 NU PROS30 PSC2	Homo sapiens (Human)	263	FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		immune system process [GO:0002376]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]	lipopolysaccharide binding [GO:0001530]; RNA binding [GO:0003723]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; lipopolysaccharide binding [GO:0001530]; RNA binding [GO:0003723]; immune system process [GO:0002376]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
P25787	reviewed	PSA2_HUMAN	Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3)	PSMA2 HC3 PSC3	Homo sapiens (Human)	234	FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; secretory granule lumen [GO:0034774]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; secretory granule lumen [GO:0034774]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951). Colocalizes with TRIM5 in cytoplasmic bodies (By similarity). {ECO:0000250|UniProtKB:P49722, ECO:0000269|PubMed:34711951}.
P25788	reviewed	PSA3_HUMAN	Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)	PSMA3 HC8 PSC8	Homo sapiens (Human)	255	FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}.		proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of endopeptidase activity [GO:0052548]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; synapse [GO:0045202]	ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; synapse [GO:0045202]; ubiquitin protein ligase binding [GO:0031625]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of endopeptidase activity [GO:0052548]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
P25789	reviewed	PSA4_HUMAN	Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L)	PSMA4 HC9 PSC9	Homo sapiens (Human)	261	FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951). Colocalizes with TRIM5 in the cytoplasmic bodies (By similarity). {ECO:0000250|UniProtKB:Q9R1P0, ECO:0000269|PubMed:34711951}.
P25791	reviewed	RBTN2_HUMAN	Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)	LMO2 RBTN2 RBTNL1 RHOM2 TTG2	Homo sapiens (Human)	158	FUNCTION: Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to thyroid hormone stimulus [GO:0097067]; positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; cellular response to thyroid hormone stimulus [GO:0097067]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P25800	reviewed	RBTN1_HUMAN	Rhombotin-1 (Cysteine-rich protein TTG-1) (LIM domain only protein 1) (LMO-1) (T-cell translocation protein 1)	LMO1 RBTN1 RHOM1 TTG1	Homo sapiens (Human)	156	FUNCTION: May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. {ECO:0000269|PubMed:1703797}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of T cell homeostatic proliferation [GO:0046013]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of T cell homeostatic proliferation [GO:0046013]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P25815	reviewed	S100P_HUMAN	Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P)	S100P S100E	Homo sapiens (Human)	95	FUNCTION: May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). {ECO:0000269|PubMed:14617629, ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290}.	MISCELLANEOUS: This protein binds two calcium ions.	endothelial cell migration [GO:0043542]; response to organic substance [GO:0010033]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; transition metal ion binding [GO:0046914]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; transition metal ion binding [GO:0046914]; endothelial cell migration [GO:0043542]; response to organic substance [GO:0010033]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.
P25874	reviewed	UCP1_HUMAN	Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin)	UCP1 SLC25A7 UCP	Homo sapiens (Human)	307	FUNCTION: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960, PubMed:28781081). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity). {ECO:0000250|UniProtKB:P12242, ECO:0000269|PubMed:24196960, ECO:0000269|PubMed:28781081}.		adaptive thermogenesis [GO:1990845]; brown fat cell differentiation [GO:0050873]; cellular response to cold [GO:0070417]; cellular response to dehydroepiandrosterone [GO:1903495]; cellular response to fatty acid [GO:0071398]; cellular response to hormone stimulus [GO:0032870]; cellular response to reactive oxygen species [GO:0034614]; diet induced thermogenesis [GO:0002024]; mitochondrial transmembrane transport [GO:1990542]; mitochondrial transport [GO:0006839]; positive regulation of cold-induced thermogenesis [GO:0120162]; proton transmembrane transport [GO:1902600]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cold [GO:0009409]; response to nutrient levels [GO:0031667]; response to temperature stimulus [GO:0009266]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	cardiolipin binding [GO:1901612]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; long-chain fatty acid binding [GO:0036041]; oxidative phosphorylation uncoupler activity [GO:0017077]; proton transmembrane transporter activity [GO:0015078]; purine ribonucleotide binding [GO:0032555]; transmembrane transporter activity [GO:0022857]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; cardiolipin binding [GO:1901612]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; long-chain fatty acid binding [GO:0036041]; oxidative phosphorylation uncoupler activity [GO:0017077]; proton transmembrane transporter activity [GO:0015078]; purine ribonucleotide binding [GO:0032555]; transmembrane transporter activity [GO:0022857]; adaptive thermogenesis [GO:1990845]; brown fat cell differentiation [GO:0050873]; cellular response to cold [GO:0070417]; cellular response to dehydroepiandrosterone [GO:1903495]; cellular response to fatty acid [GO:0071398]; cellular response to hormone stimulus [GO:0032870]; cellular response to reactive oxygen species [GO:0034614]; diet induced thermogenesis [GO:0002024]; mitochondrial transmembrane transport [GO:1990542]; mitochondrial transport [GO:0006839]; positive regulation of cold-induced thermogenesis [GO:0120162]; proton transmembrane transport [GO:1902600]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cold [GO:0009409]; response to nutrient levels [GO:0031667]; response to temperature stimulus [GO:0009266]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P12242}; Multi-pass membrane protein {ECO:0000255}.
P25929	reviewed	NPY1R_HUMAN	Neuropeptide Y receptor type 1 (NPY1-R)	NPY1R NPYR NPYY1	Homo sapiens (Human)	384	FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose metabolic process [GO:0006006]; locomotory behavior [GO:0007626]; outflow tract morphogenesis [GO:0003151]; regulation of blood pressure [GO:0008217]; regulation of multicellular organism growth [GO:0040014]; sensory perception of pain [GO:0019233]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]	neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]; pancreatic polypeptide receptor activity [GO:0001602]; peptide YY receptor activity [GO:0001601]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]; pancreatic polypeptide receptor activity [GO:0001602]; peptide YY receptor activity [GO:0001601]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose metabolic process [GO:0006006]; locomotory behavior [GO:0007626]; outflow tract morphogenesis [GO:0003151]; regulation of blood pressure [GO:0008217]; regulation of multicellular organism growth [GO:0040014]; sensory perception of pain [GO:0019233]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P25940	reviewed	CO5A3_HUMAN	Collagen alpha-3(V) chain	COL5A3	Homo sapiens (Human)	1745	FUNCTION: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.		cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; skin development [GO:0043588]	collagen type V trimer [GO:0005588]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; proteoglycan binding [GO:0043394]	collagen type V trimer [GO:0005588]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; proteoglycan binding [GO:0043394]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; skin development [GO:0043588]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
P25942	reviewed	TNR5_HUMAN	Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)	CD40 TNFRSF5	Homo sapiens (Human)	277	FUNCTION: Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). {ECO:0000250|UniProtKB:P27512, ECO:0000269|PubMed:31331973}.		B cell activation [GO:0042113]; B cell mediated immunity [GO:0019724]; B cell proliferation [GO:0042100]; CD40 signaling pathway [GO:0023035]; cellular response to erythropoietin [GO:0036018]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to tumor necrosis factor [GO:0071356]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet activation [GO:0030168]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein-containing complex assembly [GO:0065003]; response to cobalamin [GO:0033590]; response to peptide [GO:1901652]; response to type II interferon [GO:0034341]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	CD40 receptor complex [GO:0035631]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; varicosity [GO:0043196]	antigen binding [GO:0003823]; enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]	CD40 receptor complex [GO:0035631]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; varicosity [GO:0043196]; antigen binding [GO:0003823]; enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]; B cell activation [GO:0042113]; B cell mediated immunity [GO:0019724]; B cell proliferation [GO:0042100]; CD40 signaling pathway [GO:0023035]; cellular response to erythropoietin [GO:0036018]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to tumor necrosis factor [GO:0071356]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet activation [GO:0030168]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein-containing complex assembly [GO:0065003]; response to cobalamin [GO:0033590]; response to peptide [GO:1901652]; response to type II interferon [GO:0034341]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	SUBCELLULAR LOCATION: [Isoform I]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform II]: Secreted.
P25963	reviewed	IKBA_HUMAN	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)	NFKBIA IKBA MAD3 NFKBI	Homo sapiens (Human)	317	FUNCTION: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:7479976, PubMed:36651806). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7796813, PubMed:7628694, PubMed:7878466, PubMed:7479976). {ECO:0000269|PubMed:1493333, ECO:0000269|PubMed:36651806, ECO:0000269|PubMed:7479976, ECO:0000269|PubMed:7628694, ECO:0000269|PubMed:7796813, ECO:0000269|PubMed:7878466}.		apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to cold [GO:0070417]; cellular response to tumor necrosis factor [GO:0071356]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; cytoplasmic sequestering of transcription factor [GO:0042994]; interleukin-1-mediated signaling pathway [GO:0070498]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of DNA binding [GO:0043392]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Notch signaling pathway [GO:0045746]; non-canonical NF-kappaB signal transduction [GO:0038061]; Notch signaling pathway [GO:0007219]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of inflammatory response [GO:0050729]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein import into nucleus [GO:0006606]; regulation of cell population proliferation [GO:0042127]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; I-kappaB/NF-kappaB complex [GO:0033256]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; NF-kappaB binding [GO:0051059]; nuclear localization sequence binding [GO:0008139]; protein sequestering activity [GO:0140311]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; I-kappaB/NF-kappaB complex [GO:0033256]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; NF-kappaB binding [GO:0051059]; nuclear localization sequence binding [GO:0008139]; protein sequestering activity [GO:0140311]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to cold [GO:0070417]; cellular response to tumor necrosis factor [GO:0071356]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; cytoplasmic sequestering of transcription factor [GO:0042994]; interleukin-1-mediated signaling pathway [GO:0070498]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of DNA binding [GO:0043392]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Notch signaling pathway [GO:0045746]; non-canonical NF-kappaB signal transduction [GO:0038061]; Notch signaling pathway [GO:0007219]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of inflammatory response [GO:0050729]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein import into nucleus [GO:0006606]; regulation of cell population proliferation [GO:0042127]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10655476}. Nucleus {ECO:0000269|PubMed:10655476, ECO:0000269|PubMed:16648481, ECO:0000269|PubMed:9566872}. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. {ECO:0000269|PubMed:10655476, ECO:0000269|PubMed:9566872}.
P26006	reviewed	ITA3_HUMAN	Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]	ITGA3 MSK18	Homo sapiens (Human)	1051	FUNCTION: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. {ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:15181153}.; FUNCTION: (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression. {ECO:0000269|PubMed:32487760}.		cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; dendritic spine maintenance [GO:0097062]; exploration behavior [GO:0035640]; heart development [GO:0007507]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; lung development [GO:0030324]; maternal process involved in female pregnancy [GO:0060135]; memory [GO:0007613]; mesodermal cell differentiation [GO:0048333]; negative regulation of cell projection organization [GO:0031345]; negative regulation of Rho protein signal transduction [GO:0035024]; nephron development [GO:0072006]; neuron migration [GO:0001764]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of BMP signaling pathway [GO:0030510]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of Wnt signaling pathway [GO:0030111]; renal filtration [GO:0097205]; response to gonadotropin [GO:0034698]; response to xenobiotic stimulus [GO:0009410]; Rho protein signal transduction [GO:0007266]; skin development [GO:0043588]; synaptic membrane adhesion [GO:0099560]	basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]; cell surface [GO:0009986]; excitatory synapse [GO:0060076]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone filopodium [GO:1990812]; integrin alpha3-beta1 complex [GO:0034667]; integrin complex [GO:0008305]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]; receptor complex [GO:0043235]; synaptic membrane [GO:0097060]	collagen binding [GO:0005518]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]	basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]; cell surface [GO:0009986]; excitatory synapse [GO:0060076]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone filopodium [GO:1990812]; integrin alpha3-beta1 complex [GO:0034667]; integrin complex [GO:0008305]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]; receptor complex [GO:0043235]; synaptic membrane [GO:0097060]; collagen binding [GO:0005518]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; dendritic spine maintenance [GO:0097062]; exploration behavior [GO:0035640]; heart development [GO:0007507]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; lung development [GO:0030324]; maternal process involved in female pregnancy [GO:0060135]; memory [GO:0007613]; mesodermal cell differentiation [GO:0048333]; negative regulation of cell projection organization [GO:0031345]; negative regulation of Rho protein signal transduction [GO:0035024]; nephron development [GO:0072006]; neuron migration [GO:0001764]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of BMP signaling pathway [GO:0030510]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of Wnt signaling pathway [GO:0030111]; renal filtration [GO:0097205]; response to gonadotropin [GO:0034698]; response to xenobiotic stimulus [GO:0009410]; Rho protein signal transduction [GO:0007266]; skin development [GO:0043588]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15611341, ECO:0000269|PubMed:32487760}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15611341}; Lipid-anchor {ECO:0000269|PubMed:15611341}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, filopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. {ECO:0000269|PubMed:10455171}.
P26010	reviewed	ITB7_HUMAN	Integrin beta-7 (Gut homing receptor beta subunit)	ITGB7	Homo sapiens (Human)	798	FUNCTION: Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract (PubMed:10837471, PubMed:14608374). Interacts also with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable). Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin (PubMed:10837471). {ECO:0000269|PubMed:10837471, ECO:0000269|PubMed:14608374, ECO:0000305|PubMed:12297042}.; FUNCTION: (Microbial infection) Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. {ECO:0000269|PubMed:18264102}.		cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell-matrix adhesion involved in ameboidal cell migration [GO:0003366]; heterotypic cell-cell adhesion [GO:0034113]; immune response in gut-associated lymphoid tissue [GO:0002387]; integrin-mediated signaling pathway [GO:0007229]; leukocyte tethering or rolling [GO:0050901]; receptor clustering [GO:0043113]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell migration [GO:0072678]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alpha4-beta7 complex [GO:0034669]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alpha4-beta7 complex [GO:0034669]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; virus receptor activity [GO:0001618]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell-matrix adhesion involved in ameboidal cell migration [GO:0003366]; heterotypic cell-cell adhesion [GO:0034113]; immune response in gut-associated lymphoid tissue [GO:0002387]; integrin-mediated signaling pathway [GO:0007229]; leukocyte tethering or rolling [GO:0050901]; receptor clustering [GO:0043113]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell migration [GO:0072678]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
P26012	reviewed	ITB8_HUMAN	Integrin beta-8	ITGB8	Homo sapiens (Human)	769	FUNCTION: Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072). It recognizes the sequence R-G-D in its ligands (PubMed:1918072). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity). {ECO:0000250|UniProtKB:Q0VBD0, ECO:0000269|PubMed:1918072, ECO:0000305|PubMed:22278742}.		cartilage development [GO:0051216]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; ganglioside metabolic process [GO:0001573]; hard palate development [GO:0060022]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; Langerhans cell differentiation [GO:0061520]; negative regulation of gene expression [GO:0010629]; placenta blood vessel development [GO:0060674]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; regulation of transforming growth factor beta activation [GO:1901388]; response to virus [GO:0009615]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alphav-beta8 complex [GO:0034686]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]	extracellular matrix protein binding [GO:1990430]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alphav-beta8 complex [GO:0034686]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; extracellular matrix protein binding [GO:1990430]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; cartilage development [GO:0051216]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; ganglioside metabolic process [GO:0001573]; hard palate development [GO:0060022]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; Langerhans cell differentiation [GO:0061520]; negative regulation of gene expression [GO:0010629]; placenta blood vessel development [GO:0060674]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; regulation of transforming growth factor beta activation [GO:1901388]; response to virus [GO:0009615]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1918072}; Single-pass type I membrane protein {ECO:0000255}.
P26022	reviewed	PTX3_HUMAN	Pentraxin-related protein PTX3 (Pentaxin-related protein PTX3) (Tumor necrosis factor alpha-induced protein 5) (TNF alpha-induced protein 5) (Tumor necrosis factor-inducible gene 14 protein) (TSG-14)	PTX3 TNFAIP5 TSG14	Homo sapiens (Human)	381	FUNCTION: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. {ECO:0000305|PubMed:12763682}.		extracellular matrix organization [GO:0030198]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation by host of viral exo-alpha-sialidase activity [GO:0044869]; negative regulation by host of viral glycoprotein metabolic process [GO:0044871]; negative regulation by host of viral process [GO:0044793]; negative regulation of exo-alpha-sialidase activity [GO:1903016]; negative regulation of glycoprotein metabolic process [GO:1903019]; negative regulation of viral entry into host cell [GO:0046597]; opsonization [GO:0008228]; ovarian cumulus expansion [GO:0001550]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phagocytosis [GO:0050766]; response to yeast [GO:0001878]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	(1->3)-beta-D-glucan binding [GO:0001872]; complement component C1q complex binding [GO:0001849]; identical protein binding [GO:0042802]; virion binding [GO:0046790]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; (1->3)-beta-D-glucan binding [GO:0001872]; complement component C1q complex binding [GO:0001849]; identical protein binding [GO:0042802]; virion binding [GO:0046790]; extracellular matrix organization [GO:0030198]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation by host of viral exo-alpha-sialidase activity [GO:0044869]; negative regulation by host of viral glycoprotein metabolic process [GO:0044871]; negative regulation by host of viral process [GO:0044793]; negative regulation of exo-alpha-sialidase activity [GO:1903016]; negative regulation of glycoprotein metabolic process [GO:1903019]; negative regulation of viral entry into host cell [GO:0046597]; opsonization [GO:0008228]; ovarian cumulus expansion [GO:0001550]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phagocytosis [GO:0050766]; response to yeast [GO:0001878]	SUBCELLULAR LOCATION: Secreted.
P26038	reviewed	MOES_HUMAN	Moesin (Membrane-organizing extension spike protein)	MSN	Homo sapiens (Human)	577	FUNCTION: Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}.		cellular response to testosterone stimulus [GO:0071394]; establishment of endothelial barrier [GO:0061028]; establishment of epithelial cell apical/basal polarity [GO:0045198]; gland morphogenesis [GO:0022612]; immunological synapse formation [GO:0001771]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; membrane to membrane docking [GO:0022614]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of gene expression [GO:0010628]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to early endosome [GO:1902966]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of lymphocyte migration [GO:2000401]; regulation of organelle assembly [GO:1902115]; T cell aggregation [GO:0070489]; T cell migration [GO:0072678]; T cell proliferation [GO:0042098]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; uropod [GO:0001931]; vesicle [GO:0031982]	actin binding [GO:0003779]; cell adhesion molecule binding [GO:0050839]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; protein kinase binding [GO:0019901]; signaling receptor binding [GO:0005102]; structural constituent of cytoskeleton [GO:0005200]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; uropod [GO:0001931]; vesicle [GO:0031982]; actin binding [GO:0003779]; cell adhesion molecule binding [GO:0050839]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; protein kinase binding [GO:0019901]; signaling receptor binding [GO:0005102]; structural constituent of cytoskeleton [GO:0005200]; cellular response to testosterone stimulus [GO:0071394]; establishment of endothelial barrier [GO:0061028]; establishment of epithelial cell apical/basal polarity [GO:0045198]; gland morphogenesis [GO:0022612]; immunological synapse formation [GO:0001771]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; membrane to membrane docking [GO:0022614]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of gene expression [GO:0010628]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to early endosome [GO:1902966]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of lymphocyte migration [GO:2000401]; regulation of organelle assembly [GO:1902115]; T cell aggregation [GO:0070489]; T cell migration [GO:0072678]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11728332, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:7884872, ECO:0000269|PubMed:9298994}; Peripheral membrane protein {ECO:0000250|UniProtKB:P26041}; Cytoplasmic side {ECO:0000250|UniProtKB:P26041}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P26041}. Apical cell membrane {ECO:0000250|UniProtKB:P26041}; Peripheral membrane protein {ECO:0000250|UniProtKB:P26041}; Cytoplasmic side {ECO:0000250|UniProtKB:P26041}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:P26041}; Peripheral membrane protein {ECO:0000250|UniProtKB:P26041}; Cytoplasmic side {ECO:0000250|UniProtKB:P26041}. Cell projection, microvillus {ECO:0000250|UniProtKB:P26041}. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment (By similarity). Localizes at the uropods of T lymphoblasts. {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:9298994}.
P26045	reviewed	PTN3_HUMAN	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1)	PTPN3 PTPH1	Homo sapiens (Human)	913	FUNCTION: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.		liver regeneration [GO:0097421]; MAPK cascade [GO:0000165]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of mitotic cell cycle [GO:0045930]; protein dephosphorylation [GO:0006470]; regulation of membrane depolarization during action potential [GO:0098902]; regulation of sodium ion transmembrane transporter activity [GO:2000649]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	ATPase binding [GO:0051117]; cytoskeletal protein binding [GO:0008092]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine phosphatase activity [GO:0004725]; sodium channel regulator activity [GO:0017080]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ATPase binding [GO:0051117]; cytoskeletal protein binding [GO:0008092]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine phosphatase activity [GO:0004725]; sodium channel regulator activity [GO:0017080]; liver regeneration [GO:0097421]; MAPK cascade [GO:0000165]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of mitotic cell cycle [GO:0045930]; protein dephosphorylation [GO:0006470]; regulation of membrane depolarization during action potential [GO:0098902]; regulation of sodium ion transmembrane transporter activity [GO:2000649]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
P26196	reviewed	DDX6_HUMAN	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK)	DDX6 HLR2 RCK	Homo sapiens (Human)	483	FUNCTION: Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:25995375, ECO:0000269|PubMed:26098573, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:31422817}.		miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; neuron differentiation [GO:0030182]; P-body assembly [GO:0033962]; stem cell population maintenance [GO:0019827]; stress granule assembly [GO:0034063]; viral RNA genome packaging [GO:0019074]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; RISC complex [GO:0016442]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; helicase activity [GO:0004386]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; RISC complex [GO:0016442]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; helicase activity [GO:0004386]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; neuron differentiation [GO:0030182]; P-body assembly [GO:0033962]; stem cell population maintenance [GO:0019827]; stress granule assembly [GO:0034063]; viral RNA genome packaging [GO:0019074]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16699599, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:25995375, ECO:0000269|PubMed:26184334, ECO:0000269|PubMed:31422817, ECO:0000269|PubMed:32354837}. Cytoplasm {ECO:0000269|PubMed:26184334, ECO:0000269|PubMed:28216671}. Nucleus {ECO:0000269|PubMed:26184334, ECO:0000269|PubMed:28216671}. Note=Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:28216671). Upon cellular stress, relocalizes to stress granules (PubMed:26184334). {ECO:0000269|PubMed:26184334, ECO:0000269|PubMed:28216671}.
P26232	reviewed	CTNA2_HUMAN	Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein)	CTNNA2 CAPR	Homo sapiens (Human)	953	FUNCTION: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}.		axonogenesis [GO:0007409]; brain morphogenesis [GO:0048854]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; dendrite morphogenesis [GO:0048813]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; prepulse inhibition [GO:0060134]; radial glia guided migration of Purkinje cell [GO:0021942]; regulation of neuron migration [GO:2001222]; regulation of neuron projection development [GO:0010975]; regulation of synapse structural plasticity [GO:0051823]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; axon [GO:0030424]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; axon [GO:0030424]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; structural constituent of cytoskeleton [GO:0005200]; axonogenesis [GO:0007409]; brain morphogenesis [GO:0048854]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; dendrite morphogenesis [GO:0048813]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; prepulse inhibition [GO:0060134]; radial glia guided migration of Purkinje cell [GO:0021942]; regulation of neuron migration [GO:2001222]; regulation of neuron projection development [GO:0010975]; regulation of synapse structural plasticity [GO:0051823]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q61301}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q61301}; Cytoplasmic side {ECO:0000250|UniProtKB:Q61301}. Cytoplasm {ECO:0000269|PubMed:16182284}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q61301}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q61301}. Cell projection, axon {ECO:0000250|UniProtKB:Q61301}. Nucleus {ECO:0000269|PubMed:16182284}.
P26358	reviewed	DNMT1_HUMAN	DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)	DNMT1 AIM CXXC9 DNMT	Homo sapiens (Human)	1616	FUNCTION: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}.		cellular response to amino acid stimulus [GO:0071230]; cellular response to bisphenol A [GO:1903926]; DNA methylation on cytosine within a CG sequence [GO:0010424]; DNA methylation-dependent heterochromatin formation [GO:0006346]; DNA-templated transcription [GO:0006351]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of gene expression [GO:0010629]; negative regulation of gene expression via CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460]; negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [GO:1905931]; positive regulation of gene expression [GO:0010628]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; post-fertilization epigenetic regulation of gene expression [GO:0043045]	female germ cell nucleus [GO:0001674]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; replication fork [GO:0005657]	DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA binding [GO:0003677]; DNA-methyltransferase activity [GO:0009008]; methyl-CpG binding [GO:0008327]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	female germ cell nucleus [GO:0001674]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; replication fork [GO:0005657]; DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA binding [GO:0003677]; DNA-methyltransferase activity [GO:0009008]; methyl-CpG binding [GO:0008327]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; cellular response to amino acid stimulus [GO:0071230]; cellular response to bisphenol A [GO:1903926]; DNA methylation on cytosine within a CG sequence [GO:0010424]; DNA methylation-dependent heterochromatin formation [GO:0006346]; DNA-templated transcription [GO:0006351]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of gene expression [GO:0010629]; negative regulation of gene expression via CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460]; negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [GO:1905931]; positive regulation of gene expression [GO:0010628]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; post-fertilization epigenetic regulation of gene expression [GO:0043045]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12145218, ECO:0000269|PubMed:24492612}. Note=Localized to the perinucleolar region. {ECO:0000269|PubMed:24492612}.
P26367	reviewed	PAX6_HUMAN	Paired box protein Pax-6 (Aniridia type II protein) (Oculorhombin)	PAX6 AN2	Homo sapiens (Human)	422	FUNCTION: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P63015}.		anatomical structure development [GO:0048856]; animal organ morphogenesis [GO:0009887]; astrocyte differentiation [GO:0048708]; axon guidance [GO:0007411]; blood vessel development [GO:0001568]; cell fate determination [GO:0001709]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; central nervous system development [GO:0007417]; cerebellum development [GO:0021549]; cerebral cortex regionalization [GO:0021796]; chromatin remodeling [GO:0006338]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; cornea development in camera-type eye [GO:0061303]; DNA demethylation [GO:0080111]; DNA methylation [GO:0006306]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; establishment of mitotic spindle orientation [GO:0000132]; eye development [GO:0001654]; eye photoreceptor cell development [GO:0042462]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain-midbrain boundary formation [GO:0021905]; glucose homeostasis [GO:0042593]; habenula development [GO:0021986]; insulin metabolic process [GO:1901142]; interkinetic nuclear migration [GO:0022027]; iris morphogenesis [GO:0061072]; keratinocyte differentiation [GO:0030216]; lacrimal gland development [GO:0032808]; learned vocalization behavior or vocal learning [GO:0098598]; lens development in camera-type eye [GO:0002088]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; neuron fate commitment [GO:0048663]; olfactory bulb mitral cell layer development [GO:0061034]; oligodendrocyte cell fate specification [GO:0021778]; pancreatic A cell development [GO:0003322]; pituitary gland development [GO:0021983]; positive regulation of cell fate specification [GO:0042660]; positive regulation of core promoter binding [GO:1904798]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamatergic neuron differentiation [GO:0120008]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron migration [GO:2001224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to organelle [GO:0033365]; regulation of asymmetric cell division [GO:0009786]; regulation of neuron projection development [GO:0010975]; regulation of timing of cell differentiation [GO:0048505]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ethanol [GO:0045471]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; rhombomere morphogenesis [GO:0021593]; salivary gland morphogenesis [GO:0007435]; sensory neuron migration [GO:1904937]; signal transduction involved in regulation of gene expression [GO:0023019]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell differentiation [GO:0003309]; ventral spinal cord development [GO:0021517]; visual perception [GO:0007601]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; HMG box domain binding [GO:0071837]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; HMG box domain binding [GO:0071837]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; ubiquitin protein ligase binding [GO:0031625]; anatomical structure development [GO:0048856]; animal organ morphogenesis [GO:0009887]; astrocyte differentiation [GO:0048708]; axon guidance [GO:0007411]; blood vessel development [GO:0001568]; cell fate determination [GO:0001709]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; central nervous system development [GO:0007417]; cerebellum development [GO:0021549]; cerebral cortex regionalization [GO:0021796]; chromatin remodeling [GO:0006338]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; cornea development in camera-type eye [GO:0061303]; DNA demethylation [GO:0080111]; DNA methylation [GO:0006306]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; establishment of mitotic spindle orientation [GO:0000132]; eye development [GO:0001654]; eye photoreceptor cell development [GO:0042462]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain-midbrain boundary formation [GO:0021905]; glucose homeostasis [GO:0042593]; habenula development [GO:0021986]; insulin metabolic process [GO:1901142]; interkinetic nuclear migration [GO:0022027]; iris morphogenesis [GO:0061072]; keratinocyte differentiation [GO:0030216]; lacrimal gland development [GO:0032808]; learned vocalization behavior or vocal learning [GO:0098598]; lens development in camera-type eye [GO:0002088]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; neuron fate commitment [GO:0048663]; olfactory bulb mitral cell layer development [GO:0061034]; oligodendrocyte cell fate specification [GO:0021778]; pancreatic A cell development [GO:0003322]; pituitary gland development [GO:0021983]; positive regulation of cell fate specification [GO:0042660]; positive regulation of core promoter binding [GO:1904798]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamatergic neuron differentiation [GO:0120008]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron migration [GO:2001224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to organelle [GO:0033365]; regulation of asymmetric cell division [GO:0009786]; regulation of neuron projection development [GO:0010975]; regulation of timing of cell differentiation [GO:0048505]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ethanol [GO:0045471]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; rhombomere morphogenesis [GO:0021593]; salivary gland morphogenesis [GO:0007435]; sensory neuron migration [GO:1904937]; signal transduction involved in regulation of gene expression [GO:0023019]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell differentiation [GO:0003309]; ventral spinal cord development [GO:0021517]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P63015}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:P63016}.; SUBCELLULAR LOCATION: [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016}.
P26368	reviewed	U2AF2_HUMAN	Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)	U2AF2 U2AF65	Homo sapiens (Human)	475	FUNCTION: Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186). {ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:19470458, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:21536736}.		mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of RNA splicing [GO:0033120]	commitment complex [GO:0000243]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type prespliceosome [GO:0071004]; U2AF complex [GO:0089701]	C2H2 zinc finger domain binding [GO:0070742]; enzyme binding [GO:0019899]; molecular function inhibitor activity [GO:0140678]; poly-pyrimidine tract binding [GO:0008187]; pre-mRNA 3'-splice site binding [GO:0030628]; RNA binding [GO:0003723]	commitment complex [GO:0000243]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type prespliceosome [GO:0071004]; U2AF complex [GO:0089701]; C2H2 zinc finger domain binding [GO:0070742]; enzyme binding [GO:0019899]; molecular function inhibitor activity [GO:0140678]; poly-pyrimidine tract binding [GO:0008187]; pre-mRNA 3'-splice site binding [GO:0030628]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of RNA splicing [GO:0033120]	SUBCELLULAR LOCATION: Nucleus.
P26371	reviewed	KRA59_HUMAN	Keratin-associated protein 5-9 (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (Keratin-associated protein 5.9) (UHS keratin A) (UHS KerA) (Ultrahigh sulfur keratin-associated protein 5.9)	KRTAP5-9 KAP5.9 KRN1 KRTAP5.9 UHSK1	Homo sapiens (Human)	169	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.		epidermis development [GO:0008544]	cytosol [GO:0005829]; intermediate filament [GO:0005882]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; intermediate filament [GO:0005882]; identical protein binding [GO:0042802]; epidermis development [GO:0008544]	
P26373	reviewed	RL13_HUMAN	Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1)	RPL13 BBC1 OK/SW-cl.46	Homo sapiens (Human)	211	FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:31630789, PubMed:23636399, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (PubMed:31630789). Plays a role in bone development (PubMed:31630789). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:31630789, ECO:0000269|PubMed:32669547}.		blastocyst development [GO:0001824]; bone development [GO:0060348]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; synapse [GO:0045202]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; blastocyst development [GO:0001824]; bone development [GO:0060348]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399, ECO:0000305|PubMed:31630789}.
P26374	reviewed	RAE2_HUMAN	Rab proteins geranylgeranyltransferase component A 2 (Choroideremia-like protein) (Rab escort protein 2) (REP-2)	CHML REP2	Homo sapiens (Human)	656	FUNCTION: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. {ECO:0000269|PubMed:12356470, ECO:0000269|PubMed:15186776, ECO:0000269|PubMed:8294464}.	MISCELLANEOUS: Substitutes for REP-1 thereby preventing widespread tissue abnormalities in patients with choroideremia who lack REP-1.	intracellular protein transport [GO:0006886]; protein geranylgeranylation [GO:0018344]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rab-protein geranylgeranyltransferase complex [GO:0005968]	GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rab-protein geranylgeranyltransferase complex [GO:0005968]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; intracellular protein transport [GO:0006886]; protein geranylgeranylation [GO:0018344]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12356470}.
P26378	reviewed	ELAV4_HUMAN	ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD)	ELAVL4 HUD PNEM	Homo sapiens (Human)	385	FUNCTION: RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed:12034726). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:12034726). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:12034726, PubMed:12468554, PubMed:17234598, PubMed:18218628). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed:12468554, PubMed:17234598). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed:24857657). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:12034726). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed:17035636). {ECO:0000250|UniProtKB:O09032, ECO:0000250|UniProtKB:Q61701, ECO:0000269|PubMed:10710437, ECO:0000269|PubMed:12034726, ECO:0000269|PubMed:12468554, ECO:0000269|PubMed:17035636, ECO:0000269|PubMed:17234598, ECO:0000269|PubMed:18218628, ECO:0000269|PubMed:24857657, ECO:0000269|PubMed:7898713}.		3'-UTR-mediated mRNA stabilization [GO:0070935]; associative learning [GO:0008306]; cellular response to nerve growth factor stimulus [GO:1990090]; cerebral cortex neuron differentiation [GO:0021895]; dendrite morphogenesis [GO:0048813]; locomotory behavior [GO:0007626]; mRNA processing [GO:0006397]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; positive regulation of dendrite development [GO:1900006]; regeneration [GO:0031099]; regulation of translation at postsynapse [GO:0140245]; response to cocaine [GO:0042220]; response to endoplasmic reticulum stress [GO:0034976]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; nuclear envelope [GO:0005635]; perikaryon [GO:0043204]; polysomal ribosome [GO:0042788]; postsynapse [GO:0098794]	mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; pre-mRNA intronic pyrimidine-rich binding [GO:0097158]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; nuclear envelope [GO:0005635]; perikaryon [GO:0043204]; polysomal ribosome [GO:0042788]; postsynapse [GO:0098794]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; pre-mRNA intronic pyrimidine-rich binding [GO:0097158]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; associative learning [GO:0008306]; cellular response to nerve growth factor stimulus [GO:1990090]; cerebral cortex neuron differentiation [GO:0021895]; dendrite morphogenesis [GO:0048813]; locomotory behavior [GO:0007626]; mRNA processing [GO:0006397]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; positive regulation of dendrite development [GO:1900006]; regeneration [GO:0031099]; regulation of translation at postsynapse [GO:0140245]; response to cocaine [GO:0042220]; response to endoplasmic reticulum stress [GO:0034976]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21088113}. Perikaryon {ECO:0000250|UniProtKB:O09032}. Cell projection, dendrite {ECO:0000250|UniProtKB:O09032}. Cell projection, axon {ECO:0000250|UniProtKB:Q61701}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q61701}. Note=Co-localizes with ribosomal RNA in polysomes. {ECO:0000250|UniProtKB:O09032}.
P26436	reviewed	ASPX_HUMAN	Acrosomal protein SP-10 (Acrosomal vesicle protein 1)	ACRV1	Homo sapiens (Human)	265			spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]		acrosomal vesicle [GO:0001669]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Nascent acrosomal vesicle of Golgi phase spermatids.
P26439	reviewed	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) (3-beta-HSD adrenal and gonadal type) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)]	HSD3B2 HSDB3B	Homo sapiens (Human)	372	FUNCTION: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. {ECO:0000269|PubMed:1741954}.		androgen biosynthetic process [GO:0006702]; C21-steroid hormone metabolic process [GO:0008207]; hippocampus development [GO:0021766]; response to corticosterone [GO:0051412]; steroid biosynthetic process [GO:0006694]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; nucleolus [GO:0005730]; smooth endoplasmic reticulum membrane [GO:0030868]	3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; cholesterol dehydrogenase activity [GO:0102294]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid delta-isomerase activity [GO:0004769]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; nucleolus [GO:0005730]; smooth endoplasmic reticulum membrane [GO:0030868]; 3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; cholesterol dehydrogenase activity [GO:0102294]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid delta-isomerase activity [GO:0004769]; androgen biosynthetic process [GO:0006702]; C21-steroid hormone metabolic process [GO:0008207]; hippocampus development [GO:0021766]; response to corticosterone [GO:0051412]; steroid biosynthetic process [GO:0006694]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25322271}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane; Single-pass membrane protein {ECO:0000255}.
P26440	reviewed	IVD_HUMAN	Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4) (Butyryl-CoA dehydrogenase) (EC 1.3.8.1)	IVD	Homo sapiens (Human)	426	FUNCTION: Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway (PubMed:7640268). To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA (PubMed:7640268). {ECO:0000269|PubMed:7640268}.		branched-chain amino acid catabolic process [GO:0009083]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; leucine catabolic process [GO:0006552]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	butyryl-CoA dehydrogenase activity [GO:0004085]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; isovaleryl-CoA dehydrogenase activity [GO:0008470]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; butyryl-CoA dehydrogenase activity [GO:0004085]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; isovaleryl-CoA dehydrogenase activity [GO:0008470]; branched-chain amino acid catabolic process [GO:0009083]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; leucine catabolic process [GO:0006552]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P12007}.
P26441	reviewed	CNTF_HUMAN	Ciliary neurotrophic factor (CNTF)	CNTF	Homo sapiens (Human)	200	FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.		astrocyte activation [GO:0048143]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; muscle organ morphogenesis [GO:0048644]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of photoreceptor cell differentiation [GO:0046533]; neuron development [GO:0048666]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of retinal cell programmed cell death [GO:0046668]; retinal rod cell differentiation [GO:0060221]; signal transduction [GO:0007165]	axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-6 receptor binding [GO:0005138]; protein-containing complex binding [GO:0044877]	axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-6 receptor binding [GO:0005138]; protein-containing complex binding [GO:0044877]; astrocyte activation [GO:0048143]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; muscle organ morphogenesis [GO:0048644]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of photoreceptor cell differentiation [GO:0046533]; neuron development [GO:0048666]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of retinal cell programmed cell death [GO:0046668]; retinal rod cell differentiation [GO:0060221]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm.
P26447	reviewed	S10A4_HUMAN	Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)	S100A4 CAPL MTS1	Homo sapiens (Human)	101	FUNCTION: Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:30713770, PubMed:26654597). {ECO:0000250|UniProtKB:P07091, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:23752197, ECO:0000269|PubMed:26654597, ECO:0000269|PubMed:30713770}.		epithelial to mesenchymal transition [GO:0001837]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	actin binding [GO:0003779]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; chemoattractant activity [GO:0042056]; identical protein binding [GO:0042802]; RAGE receptor binding [GO:0050786]; RNA binding [GO:0003723]; transition metal ion binding [GO:0046914]	collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; actin binding [GO:0003779]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; chemoattractant activity [GO:0042056]; identical protein binding [GO:0042802]; RAGE receptor binding [GO:0050786]; RNA binding [GO:0003723]; transition metal ion binding [GO:0046914]; epithelial to mesenchymal transition [GO:0001837]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26654597, ECO:0000269|PubMed:30713770}. Nucleus {ECO:0000269|PubMed:23752197}. Cytoplasm {ECO:0000250|UniProtKB:P07091}.
P26572	reviewed	MGAT1_HUMAN	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (GNT-I) (GlcNAc-T I)	MGAT1 GGNT1 GLCT1 GLYT1 MGAT	Homo sapiens (Human)	445	FUNCTION: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. {ECO:0000269|PubMed:1702225}.		in utero embryonic development [GO:0001701]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; UDP-N-acetylglucosamine catabolic process [GO:0006049]; viral protein processing [GO:0019082]	endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0003827]; manganese ion binding [GO:0030145]	endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0003827]; manganese ion binding [GO:0030145]; in utero embryonic development [GO:0001701]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; UDP-N-acetylglucosamine catabolic process [GO:0006049]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:20378551}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:30983867}. Note=Co-localizes with BRI3 isoform 1 at the perinuclear region. {ECO:0000269|PubMed:30983867}.
P26583	reviewed	HMGB2_HUMAN	High mobility group protein B2 (High mobility group protein 2) (HMG-2)	HMGB2 HMG2	Homo sapiens (Human)	209	FUNCTION: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). {ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P30681, ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:18413230, ECO:0000269|PubMed:19522541, ECO:0000269|PubMed:19811285, ECO:0000269|PubMed:19965638, ECO:0000269|PubMed:23877675, ECO:0000269|PubMed:7797075, ECO:0000305|PubMed:20123072}.		cell chemotaxis [GO:0060326]; cellular response to lipopolysaccharide [GO:0071222]; chromatin organization [GO:0006325]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; DNA geometric change [GO:0032392]; DNA topological change [GO:0006265]; double-strand break repair via nonhomologous end joining [GO:0006303]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; male gonad development [GO:0008584]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of nuclease activity [GO:0032075]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; response to steroid hormone [GO:0048545]; spermatid nucleus differentiation [GO:0007289]; V(D)J recombination [GO:0033151]	chromatin [GO:0000785]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	chemoattractant activity [GO:0042056]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; non-sequence-specific DNA binding, bending [GO:0044378]; protein domain specific binding [GO:0019904]; RAGE receptor binding [GO:0050786]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]	chromatin [GO:0000785]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; chemoattractant activity [GO:0042056]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; non-sequence-specific DNA binding, bending [GO:0044378]; protein domain specific binding [GO:0019904]; RAGE receptor binding [GO:0050786]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; cell chemotaxis [GO:0060326]; cellular response to lipopolysaccharide [GO:0071222]; chromatin organization [GO:0006325]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; DNA geometric change [GO:0032392]; DNA topological change [GO:0006265]; double-strand break repair via nonhomologous end joining [GO:0006303]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; male gonad development [GO:0008584]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of nuclease activity [GO:0032075]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; response to steroid hormone [GO:0048545]; spermatid nucleus differentiation [GO:0007289]; V(D)J recombination [GO:0033151]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:12925773, ECO:0000269|PubMed:23877675}. Chromosome {ECO:0000269|PubMed:12925773}. Cytoplasm {ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:23877675}. Secreted {ECO:0000269|PubMed:19811285, ECO:0000269|PubMed:23877675}. Note=In basal state predominantly nuclear. {ECO:0000305}.
P26599	reviewed	PTBP1_HUMAN	Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)	PTBP1 PTB	Homo sapiens (Human)	557	FUNCTION: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9 (PubMed:14966131). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:14966131, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:16179478, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:21518806}.		IRES-dependent viral translational initiation [GO:0075522]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of RNA splicing [GO:0033119]; neurogenesis [GO:0022008]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of cell differentiation [GO:0045595]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; mRNA binding [GO:0003729]; poly-pyrimidine tract binding [GO:0008187]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; mRNA binding [GO:0003729]; poly-pyrimidine tract binding [GO:0008187]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; IRES-dependent viral translational initiation [GO:0075522]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of RNA splicing [GO:0033119]; neurogenesis [GO:0022008]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of cell differentiation [GO:0045595]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus.
P26639	reviewed	SYTC_HUMAN	Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1)	TARS1 TARS	Homo sapiens (Human)	723	FUNCTION: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}.		threonyl-tRNA aminoacylation [GO:0006435]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; threonine-tRNA ligase activity [GO:0004829]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; threonine-tRNA ligase activity [GO:0004829]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; threonyl-tRNA aminoacylation [GO:0006435]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D0R2}.
P26640	reviewed	SYVC_HUMAN	Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS)	VARS1 G7A VARS VARS2	Homo sapiens (Human)	1264	FUNCTION: Catalyzes the attachment of valine to tRNA(Val). {ECO:0000269|PubMed:8428657}.		tRNA aminoacylation for protein translation [GO:0006418]; valyl-tRNA aminoacylation [GO:0006438]	cytosol [GO:0005829]	aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832]	cytosol [GO:0005829]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832]; tRNA aminoacylation for protein translation [GO:0006418]; valyl-tRNA aminoacylation [GO:0006438]	
P26641	reviewed	EF1G_HUMAN	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)	EEF1G EF1G PRO1608	Homo sapiens (Human)	437	FUNCTION: Probably plays a role in anchoring the complex to other cellular components.		response to virus [GO:0009615]; translational elongation [GO:0006414]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; translation elongation factor activity [GO:0003746]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; translation elongation factor activity [GO:0003746]; response to virus [GO:0009615]; translational elongation [GO:0006414]	
P26651	reviewed	TTP_HUMAN	mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36)	ZFP36 G0S24 NUP475 RNF162A TIS11A TTP	Homo sapiens (Human)	326	FUNCTION: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:9703499, PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:27193233, PubMed:23644599, PubMed:25815583, PubMed:31439631). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:19188452, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; hematopoietic stem cell differentiation [GO:0060218]; MAPK cascade [GO:0000165]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA catabolic process [GO:0006402]; mRNA transport [GO:0051028]; myeloid cell differentiation [GO:0030099]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of polynucleotide adenylyltransferase activity [GO:1904246]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral transcription [GO:0032897]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; p38MAPK cascade [GO:0038066]; positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA [GO:1901835]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of keratinocyte apoptotic process [GO:1902172]; regulation of keratinocyte differentiation [GO:0045616]; regulation of keratinocyte proliferation [GO:0010837]; regulation of mRNA stability [GO:0043488]; regulation of tumor necrosis factor production [GO:0032680]; response to starvation [GO:0042594]; response to wounding [GO:0009611]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]	14-3-3 protein binding [GO:0071889]; C-C chemokine binding [GO:0019957]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]; 14-3-3 protein binding [GO:0071889]; C-C chemokine binding [GO:0019957]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; hematopoietic stem cell differentiation [GO:0060218]; MAPK cascade [GO:0000165]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA catabolic process [GO:0006402]; mRNA transport [GO:0051028]; myeloid cell differentiation [GO:0030099]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of polynucleotide adenylyltransferase activity [GO:1904246]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral transcription [GO:0032897]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; p38MAPK cascade [GO:0038066]; positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA [GO:1901835]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of keratinocyte apoptotic process [GO:1902172]; regulation of keratinocyte differentiation [GO:0045616]; regulation of keratinocyte proliferation [GO:0010837]; regulation of mRNA stability [GO:0043488]; regulation of tumor necrosis factor production [GO:0032680]; response to starvation [GO:0042594]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:27182009}. Cytoplasm {ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:14766228, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:20221403}. Cytoplasmic granule {ECO:0000269|PubMed:15014438}. Cytoplasm, P-body {ECO:0000269|PubMed:17369404}. Note=Shuttles between nucleus and cytoplasm in a CRM1-dependent manner (By similarity). Localized predominantly in the cytoplasm in a p38 MAPK- and YWHAB-dependent manner (By similarity). Colocalizes with SH3KBP1 and MAP3K4 in the cytoplasm (PubMed:20221403). Component of cytoplasmic stress granules (SGs) (By similarity). Localizes to cytoplasmic stress granules upon energy starvation (PubMed:15014438). Localizes in processing bodies (PBs) (PubMed:17369404). Excluded from stress granules in a phosphorylation MAPKAPK2-dependent manner (By similarity). Shuttles in and out of both cytoplasmic P-body and SGs (By similarity). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:20221403}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14679154}. Cytoplasm {ECO:0000269|PubMed:14679154}. Note=(Microbial infection) Colocalizes with HTLV-1 TAX in the nucleus and the cytoplasm in a region surrounding the nucleus. {ECO:0000269|PubMed:14679154}.
P26678	reviewed	PPLA_HUMAN	Cardiac phospholamban (PLB)	PLN PLB	Homo sapiens (Human)	52	FUNCTION: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation (By similarity). {ECO:0000250|UniProtKB:P61014, ECO:0000269|PubMed:22427649, ECO:0000269|PubMed:22707725, ECO:0000269|PubMed:28890335}.	MISCELLANEOUS: For practical reasons, PLN activity is most often studied with ATP2A1 instead of ATP2A2.	acrosome assembly [GO:0001675]; adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0086023]; blood circulation [GO:0008015]; cardiac muscle tissue development [GO:0048738]; intracellular calcium ion homeostasis [GO:0006874]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901895]; negative regulation of calcium ion binding [GO:1901877]; negative regulation of calcium ion import [GO:0090281]; negative regulation of calcium ion import into sarcoplasmic reticulum [GO:1902081]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of catalytic activity [GO:0043086]; negative regulation of heart rate [GO:0010459]; Notch signaling pathway [GO:0007219]; regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901894]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart contraction [GO:0008016]; regulation of relaxation of cardiac muscle [GO:1901897]; regulation of the force of heart contraction [GO:0002026]; regulation of the force of heart contraction by cardiac conduction [GO:0086092]; relaxation of cardiac muscle [GO:0055119]	calcium ion-transporting ATPase complex [GO:0090534]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]	ATPase binding [GO:0051117]; ATPase inhibitor activity [GO:0042030]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	calcium ion-transporting ATPase complex [GO:0090534]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; ATPase binding [GO:0051117]; ATPase inhibitor activity [GO:0042030]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; acrosome assembly [GO:0001675]; adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0086023]; blood circulation [GO:0008015]; cardiac muscle tissue development [GO:0048738]; intracellular calcium ion homeostasis [GO:0006874]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901895]; negative regulation of calcium ion binding [GO:1901877]; negative regulation of calcium ion import [GO:0090281]; negative regulation of calcium ion import into sarcoplasmic reticulum [GO:1902081]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of catalytic activity [GO:0043086]; negative regulation of heart rate [GO:0010459]; Notch signaling pathway [GO:0007219]; regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901894]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart contraction [GO:0008016]; regulation of relaxation of cardiac muscle [GO:1901897]; regulation of the force of heart contraction [GO:0002026]; regulation of the force of heart contraction by cardiac conduction [GO:0086092]; relaxation of cardiac muscle [GO:0055119]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17241641}; Single-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:12804600, ECO:0000269|PubMed:15598648, ECO:0000269|PubMed:22427649}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:A4IFH6}; Single-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:P61014}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648). {ECO:0000269|PubMed:15598648, ECO:0000269|PubMed:17241641}.
P26715	reviewed	NKG2A_HUMAN	NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a)	KLRC1 NKG2A	Homo sapiens (Human)	233	FUNCTION: Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:9486650, PubMed:18083576, PubMed:9430220, PubMed:37264229). Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:9485206, PubMed:12165520). Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:9486650, PubMed:9430220, PubMed:9485206, PubMed:30860984). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984). {ECO:0000269|PubMed:12165520, ECO:0000269|PubMed:12387742, ECO:0000269|PubMed:18064301, ECO:0000269|PubMed:18083576, ECO:0000269|PubMed:30503213, ECO:0000269|PubMed:30860984, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9430220, ECO:0000269|PubMed:9485206, ECO:0000269|PubMed:9486650}.; FUNCTION: (Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells. Recognizes HLA-E in complex with human cytomegalovirus UL40-derived peptide (VMAPRTLIL) and inhibits NK cell cytotoxicity. {ECO:0000269|PubMed:10669413, ECO:0000269|PubMed:23335510}.; FUNCTION: (Microbial infection) May recognize HLA-E in complex with HIV-1 gag/Capsid protein p24-derived peptide (AISPRTLNA) on infected cells and may inhibit NK cell cytotoxicity, a mechanism that allows HIV-1 to escape immune recognition. {ECO:0000269|PubMed:15751767}.; FUNCTION: (Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells (PubMed:32203188, PubMed:32859121). On NK cells, may recognize HLA-E in complex with SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening antiviral immune surveillance (PubMed:32859121). {ECO:0000269|PubMed:32203188, ECO:0000269|PubMed:32859121}.		adaptive immune response [GO:0002250]; CD8-positive, gamma-delta intraepithelial T cell differentiation [GO:0002305]; cell surface receptor signaling pathway [GO:0007166]; innate immune response [GO:0045087]; natural killer cell inhibitory signaling pathway [GO:0002769]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	carbohydrate binding [GO:0030246]; HLA-E specific inhibitory MHC class Ib receptor activity [GO:0062082]; MHC class I protein complex binding [GO:0023024]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; carbohydrate binding [GO:0030246]; HLA-E specific inhibitory MHC class Ib receptor activity [GO:0062082]; MHC class I protein complex binding [GO:0023024]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; CD8-positive, gamma-delta intraepithelial T cell differentiation [GO:0002305]; cell surface receptor signaling pathway [GO:0007166]; innate immune response [GO:0045087]; natural killer cell inhibitory signaling pathway [GO:0002769]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12165520, ECO:0000269|PubMed:20952657}; Single-pass type II membrane protein {ECO:0000255}.
P26717	reviewed	NKG2C_HUMAN	NKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c)	KLRC2 NKG2C	Homo sapiens (Human)	231	FUNCTION: Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159, PubMed:37264229). Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed:21825173, PubMed:20952657). Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed:9655483, PubMed:15940674). {ECO:0000269|PubMed:15940674, ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:21825173, ECO:0000269|PubMed:30134159, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9655483, ECO:0000269|PubMed:9754572}.		adaptive immune response [GO:0002250]; cellular defense response [GO:0006968]; natural killer cell mediated immunity [GO:0002228]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	activating MHC class Ib receptor activity [GO:0062081]; carbohydrate binding [GO:0030246]; MHC class I protein complex binding [GO:0023024]; protein antigen binding [GO:1990405]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; activating MHC class Ib receptor activity [GO:0062081]; carbohydrate binding [GO:0030246]; MHC class I protein complex binding [GO:0023024]; protein antigen binding [GO:1990405]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; cellular defense response [GO:0006968]; natural killer cell mediated immunity [GO:0002228]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:21825173}; Single-pass type II membrane protein {ECO:0000255}.
P26718	reviewed	NKG2D_HUMAN	NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)	KLRK1 D12S2489E NKG2D	Homo sapiens (Human)	216	FUNCTION: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:19658097, ECO:0000269|PubMed:21898152, ECO:0000269|PubMed:23298206, ECO:0000269|PubMed:28559451}.	MISCELLANEOUS: Is not capable of signal transduction by itself, but operates through the adapter protein HCST (PubMed:10426994, PubMed:15894612). Some families of ligands for human and mouse KLRK1 receptors have been characterized being very similar in structure and highly likely to be orthologs. In humans, an additional distinct subfamily of ligands (MICA and MICB) differs structurally, having an extra MHC alpha 3-like domain (PubMed:23298206). {ECO:0000305|PubMed:23298206}.	adaptive immune response [GO:0002250]; cell differentiation [GO:0030154]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-positive bacterium [GO:0050830]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of GTPase activity [GO:0034260]; negative regulation of natural killer cell chemotaxis [GO:2000502]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell costimulation [GO:0031295]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; MHC class I protein binding [GO:0042288]; MHC class Ib receptor activity [GO:0032394]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; MHC class I protein binding [GO:0042288]; MHC class Ib receptor activity [GO:0032394]; signaling receptor activity [GO:0038023]; adaptive immune response [GO:0002250]; cell differentiation [GO:0030154]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-positive bacterium [GO:0050830]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of GTPase activity [GO:0034260]; negative regulation of natural killer cell chemotaxis [GO:2000502]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}; Single-pass type II membrane protein {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}. Note=Colocalized with HCST on the cell surface.
P26842	reviewed	CD27_HUMAN	CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27)	CD27 TNFRSF7	Homo sapiens (Human)	260	FUNCTION: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.		cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway [GO:0097191]; immunoglobulin mediated immune response [GO:0016064]; negative regulation of apoptotic process [GO:0043066]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of JNK cascade [GO:0046330]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell differentiation [GO:0045582]; response to ethanol [GO:0045471]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway [GO:0097191]; immunoglobulin mediated immune response [GO:0016064]; negative regulation of apoptotic process [GO:0043066]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of JNK cascade [GO:0046330]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell differentiation [GO:0045582]; response to ethanol [GO:0045471]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P26885	reviewed	FKBP2_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase)	FKBP2 FKBP13	Homo sapiens (Human)	142	FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.		chaperone-mediated protein folding [GO:0061077]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; chaperone-mediated protein folding [GO:0061077]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
P26927	reviewed	HGFL_HUMAN	Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (Macrophage-stimulating protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain]	MST1 D3F15S2 DNF15S2 HGFL	Homo sapiens (Human)	711			negative regulation of gluconeogenesis [GO:0045721]; proteolysis [GO:0006508]; regulation of cAMP-dependent protein kinase activity [GO:2000479]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	receptor tyrosine kinase binding [GO:0030971]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; receptor tyrosine kinase binding [GO:0030971]; negative regulation of gluconeogenesis [GO:0045721]; proteolysis [GO:0006508]; regulation of cAMP-dependent protein kinase activity [GO:2000479]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	SUBCELLULAR LOCATION: Secreted.
P26951	reviewed	IL3RA_HUMAN	Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)	IL3RA IL3R	Homo sapiens (Human)	378	FUNCTION: Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity). {ECO:0000250|UniProtKB:P26952, ECO:0000269|PubMed:10527461, ECO:0000269|PubMed:29374162}.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.	cytokine-mediated signaling pathway [GO:0019221]; interleukin-3-mediated signaling pathway [GO:0038156]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-3 receptor activity [GO:0004912]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-3 receptor activity [GO:0004912]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-3-mediated signaling pathway [GO:0038156]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P26992	reviewed	CNTFR_HUMAN	Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)	CNTFR	Homo sapiens (Human)	372	FUNCTION: Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1 (PubMed:19386761). {ECO:0000269|PubMed:19386761, ECO:0000269|PubMed:26858303}.		brainstem development [GO:0003360]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; motor neuron apoptotic process [GO:0097049]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]; sex differentiation [GO:0007548]; signal transduction [GO:0007165]; skeletal muscle organ development [GO:0060538]; suckling behavior [GO:0001967]	apical plasma membrane [GO:0016324]; ciliary neurotrophic factor receptor complex [GO:0070110]; CNTFR-CLCF1 complex [GO:0097059]; external side of plasma membrane [GO:0009897]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]	ciliary neurotrophic factor receptor activity [GO:0004897]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; signaling receptor binding [GO:0005102]	apical plasma membrane [GO:0016324]; ciliary neurotrophic factor receptor complex [GO:0070110]; CNTFR-CLCF1 complex [GO:0097059]; external side of plasma membrane [GO:0009897]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; ciliary neurotrophic factor receptor activity [GO:0004897]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; signaling receptor binding [GO:0005102]; brainstem development [GO:0003360]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; motor neuron apoptotic process [GO:0097049]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]; sex differentiation [GO:0007548]; signal transduction [GO:0007165]; skeletal muscle organ development [GO:0060538]; suckling behavior [GO:0001967]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
P26998	reviewed	CRBB3_HUMAN	Beta-crystallin B3 (Beta-B3 crystallin) [Cleaved into: Beta-crystallin B3, N-terminally processed]	CRYBB3 CRYB3	Homo sapiens (Human)	211	FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.		lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]		structural constituent of eye lens [GO:0005212]	structural constituent of eye lens [GO:0005212]; lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]	
P27037	reviewed	AVR2A_HUMAN	Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)	ACVR2A ACVR2	Homo sapiens (Human)	513	FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed:17911401). Mediates induction of adipogenesis by GDF6 (By similarity). {ECO:0000250|UniProtKB:P27038, ECO:0000269|PubMed:1314589, ECO:0000269|PubMed:17911401}.		activin receptor signaling pathway [GO:0032924]; anterior/posterior pattern specification [GO:0009952]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; embryonic skeletal system development [GO:0048706]; gastrulation with mouth forming second [GO:0001702]; mesoderm development [GO:0007498]; odontogenesis of dentin-containing tooth [GO:0042475]; penile erection [GO:0043084]; phosphorylation [GO:0016310]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of bone mineralization [GO:0030501]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of nitric oxide biosynthetic process [GO:0045428]; Sertoli cell proliferation [GO:0060011]; sperm ejaculation [GO:0042713]; spermatogenesis [GO:0007283]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]	activin receptor complex [GO:0048179]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; inhibin-betaglycan-ActRII complex [GO:0034673]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	activin binding [GO:0048185]; activin receptor activity [GO:0017002]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; coreceptor activity [GO:0015026]; growth factor binding [GO:0019838]; inhibin binding [GO:0034711]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein self-association [GO:0043621]; protein serine/threonine kinase activity [GO:0004674]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]	activin receptor complex [GO:0048179]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; inhibin-betaglycan-ActRII complex [GO:0034673]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; activin binding [GO:0048185]; activin receptor activity [GO:0017002]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; coreceptor activity [GO:0015026]; growth factor binding [GO:0019838]; inhibin binding [GO:0034711]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein self-association [GO:0043621]; protein serine/threonine kinase activity [GO:0004674]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; activin receptor signaling pathway [GO:0032924]; anterior/posterior pattern specification [GO:0009952]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; embryonic skeletal system development [GO:0048706]; gastrulation with mouth forming second [GO:0001702]; mesoderm development [GO:0007498]; odontogenesis of dentin-containing tooth [GO:0042475]; penile erection [GO:0043084]; phosphorylation [GO:0016310]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of bone mineralization [GO:0030501]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of nitric oxide biosynthetic process [GO:0045428]; Sertoli cell proliferation [GO:0060011]; sperm ejaculation [GO:0042713]; spermatogenesis [GO:0007283]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P27038}; Single-pass type I membrane protein {ECO:0000255}.
P27105	reviewed	STOM_HUMAN	Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b)	STOM BND7 EPB72	Homo sapiens (Human)	288	FUNCTION: Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.		positive regulation by host of viral genome replication [GO:0044829]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of viral process [GO:0048524]; regulation of monoatomic ion transmembrane transport [GO:0034765]	azurophil granule membrane [GO:0035577]; blood microparticle [GO:0072562]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; vesicle [GO:0031982]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase binding [GO:0070063]	azurophil granule membrane [GO:0035577]; blood microparticle [GO:0072562]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; vesicle [GO:0031982]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase binding [GO:0070063]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of viral process [GO:0048524]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9243190}; Peripheral membrane protein {ECO:0000269|PubMed:9243190}; Cytoplasmic side {ECO:0000269|PubMed:9243190}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9243190}. Cell membrane {ECO:0000269|PubMed:12130500}; Lipid-anchor {ECO:0000269|PubMed:12130500}; Cytoplasmic side {ECO:0000269|PubMed:12130500}. Membrane raft {ECO:0000269|PubMed:12130500, ECO:0000269|PubMed:23219802}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P54116}. Note=Localizes to juxtanuclear structure probably derived from the Golgi apparatus (PubMed:9243190). Colocalizes with cortical actin microfilaments at small plasma membrane protrusions (PubMed:9243190). Associates with alpha-granular lipid rafts (PubMed:12130500). Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles (PubMed:12130500). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12130500, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:9243190}.
P27144	reviewed	KAD4_HUMAN	Adenylate kinase 4, mitochondrial (AK 4) (EC 2.7.4.10) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4)	AK4 AK3 AK3L1	Homo sapiens (Human)	223	FUNCTION: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (PubMed:19073142, PubMed:19766732, PubMed:23416111, PubMed:24767988). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (PubMed:19073142, PubMed:19766732, PubMed:23416111). Also displays broad nucleoside diphosphate kinase activity (PubMed:19073142, PubMed:19766732, PubMed:23416111). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (PubMed:24767988, PubMed:26980435). Plays a protective role in the cellular response to oxidative stress (PubMed:19130895, PubMed:23474458, PubMed:26980435). {ECO:0000255|HAMAP-Rule:MF_03170, ECO:0000269|PubMed:19073142, ECO:0000269|PubMed:19130895, ECO:0000269|PubMed:19766732, ECO:0000269|PubMed:23416111, ECO:0000269|PubMed:23474458, ECO:0000269|PubMed:24767988, ECO:0000269|PubMed:26980435}.		ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; cellular response to hypoxia [GO:0071456]; GTP metabolic process [GO:0046039]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleoside triphosphate biosynthetic process [GO:0009142]; phosphorylation [GO:0016310]; regulation of oxidative phosphorylation [GO:0002082]; ribonucleoside diphosphate biosynthetic process [GO:0009188]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside monophosphate kinase activity [GO:0050145]; nucleoside triphosphate adenylate kinase activity [GO:0046899]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside monophosphate kinase activity [GO:0050145]; nucleoside triphosphate adenylate kinase activity [GO:0046899]; ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; cellular response to hypoxia [GO:0071456]; GTP metabolic process [GO:0046039]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleoside triphosphate biosynthetic process [GO:0009142]; phosphorylation [GO:0016310]; regulation of oxidative phosphorylation [GO:0002082]; ribonucleoside diphosphate biosynthetic process [GO:0009188]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03170, ECO:0000269|PubMed:11485571, ECO:0000269|PubMed:19766732, ECO:0000269|PubMed:26980435}.
P27169	reviewed	PON1_HUMAN	Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1)	PON1 PON	Homo sapiens (Human)	355	FUNCTION: Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. {ECO:0000269|PubMed:10479665, ECO:0000269|PubMed:15772423}.	MISCELLANEOUS: The preferential association of PON1 with HDL is mediated in part by its signal peptide, by binding phospholipids directly, rather than binding apo AI. The retained signal peptide may allow transfer of the protein between phospholipid surfaces.	aromatic compound catabolic process [GO:0019439]; carboxylic acid catabolic process [GO:0046395]; cholesterol metabolic process [GO:0008203]; organophosphate catabolic process [GO:0046434]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of binding [GO:0051099]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of transporter activity [GO:0032411]; response to toxic substance [GO:0009636]	blood microparticle [GO:0072562]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; spherical high-density lipoprotein particle [GO:0034366]	acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; aryldialkylphosphatase activity [GO:0004063]; arylesterase activity [GO:0004064]; calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543]; protein homodimerization activity [GO:0042803]	blood microparticle [GO:0072562]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; spherical high-density lipoprotein particle [GO:0034366]; acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; aryldialkylphosphatase activity [GO:0004063]; arylesterase activity [GO:0004064]; calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543]; protein homodimerization activity [GO:0042803]; aromatic compound catabolic process [GO:0019439]; carboxylic acid catabolic process [GO:0046395]; cholesterol metabolic process [GO:0008203]; organophosphate catabolic process [GO:0046434]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of binding [GO:0051099]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of transporter activity [GO:0032411]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P27216	reviewed	ANX13_HUMAN	Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA)	ANXA13 ANX13	Homo sapiens (Human)	316	FUNCTION: [Isoform A]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed:27676605, PubMed:30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed:27676605). {ECO:0000269|PubMed:27676605, ECO:0000269|PubMed:30610115}.; FUNCTION: [Isoform B]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium. {ECO:0000269|PubMed:27676605}.		cell differentiation [GO:0030154]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylglycerol binding [GO:1901611]; phosphatidylserine binding [GO:0001786]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylglycerol binding [GO:1901611]; phosphatidylserine binding [GO:0001786]; cell differentiation [GO:0030154]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:1530946}. Cell membrane {ECO:0000269|PubMed:30610115}; Lipid-anchor {ECO:0000269|PubMed:30610115}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q99JG3}. Note=Myristoylation anchors the protein to the membrane, but the protein also displays calcium-dependent, reversible binding to lipid membranes (PubMed:30610115). Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes (PubMed:1530946). {ECO:0000269|PubMed:1530946, ECO:0000269|PubMed:30610115}.
P27338	reviewed	AOFB_HUMAN	Amine oxidase [flavin-containing] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B)	MAOB	Homo sapiens (Human)	520	FUNCTION: Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079). Preferentially degrades benzylamine and phenylethylamine (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079). {ECO:0000269|PubMed:11049757, ECO:0000269|PubMed:11134050, ECO:0000269|PubMed:20493079, ECO:0000269|PubMed:8316221, ECO:0000269|PubMed:8665924}.		dopamine catabolic process [GO:0042420]; hydrogen peroxide biosynthetic process [GO:0050665]; negative regulation of serotonin secretion [GO:0014063]; neurotransmitter catabolic process [GO:0042135]; positive regulation of dopamine metabolic process [GO:0045964]; response to aluminum ion [GO:0010044]; response to corticosterone [GO:0051412]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to selenium ion [GO:0010269]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; substantia nigra development [GO:0021762]	mitochondrial envelope [GO:0005740]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	aliphatic amine oxidase activity [GO:0052595]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; monoamine oxidase activity [GO:0097621]; phenethylamine:oxygen oxidoreductase (deaminating) activity [GO:0052596]; primary amine oxidase activity [GO:0008131]	mitochondrial envelope [GO:0005740]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; aliphatic amine oxidase activity [GO:0052595]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; monoamine oxidase activity [GO:0097621]; phenethylamine:oxygen oxidoreductase (deaminating) activity [GO:0052596]; primary amine oxidase activity [GO:0008131]; dopamine catabolic process [GO:0042420]; hydrogen peroxide biosynthetic process [GO:0050665]; negative regulation of serotonin secretion [GO:0014063]; neurotransmitter catabolic process [GO:0042135]; positive regulation of dopamine metabolic process [GO:0045964]; response to aluminum ion [GO:0010044]; response to corticosterone [GO:0051412]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to selenium ion [GO:0010269]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
P27348	reviewed	1433T_HUMAN	14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)	YWHAQ	Homo sapiens (Human)	245	FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monoatomic ion transmembrane transport [GO:0034766]; protein targeting [GO:0006605]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; substantia nigra development [GO:0021762]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; synapse [GO:0045202]	14-3-3 protein binding [GO:0071889]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; 14-3-3 protein binding [GO:0071889]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; transmembrane transporter binding [GO:0044325]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monoatomic ion transmembrane transport [GO:0034766]; protein targeting [GO:0006605]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.
P27352	reviewed	IF_HUMAN	Cobalamin binding intrinsic factor (Gastric intrinsic factor) (Intrinsic factor) (IF) (INF)	CBLIF GIF IFMH	Homo sapiens (Human)	417	FUNCTION: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.		cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824]	apical plasma membrane [GO:0016324]; endosome [GO:0005768]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; microvillus [GO:0005902]	cargo receptor ligand activity [GO:0140355]; cobalamin binding [GO:0031419]	apical plasma membrane [GO:0016324]; endosome [GO:0005768]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; microvillus [GO:0005902]; cargo receptor ligand activity [GO:0140355]; cobalamin binding [GO:0031419]; cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824]	SUBCELLULAR LOCATION: Secreted.
P27361	reviewed	MK03_HUMAN	Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)	MAPK3 ERK1 PRKM3	Homo sapiens (Human)	379	FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:34497368). MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DEPTOR, FRS2 or GRB10) (PubMed:35216969). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. {ECO:0000269|PubMed:10393181, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:34497368, ECO:0000269|PubMed:35216969, ECO:0000269|PubMed:8325880, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9480836}.		apoptotic process [GO:0006915]; Bergmann glial cell differentiation [GO:0060020]; BMP signaling pathway [GO:0030509]; cardiac neural crest cell development involved in heart development [GO:0061308]; cartilage development [GO:0051216]; caveolin-mediated endocytosis [GO:0072584]; cell cycle [GO:0007049]; cellular response to amino acid starvation [GO:0034198]; cellular response to cadmium ion [GO:0071276]; cellular response to mechanical stimulus [GO:0071260]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; DNA-templated transcription [GO:0006351]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; lung morphogenesis [GO:0060425]; MAPK cascade [GO:0000165]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of TORC1 signaling [GO:1904262]; outer ear morphogenesis [GO:0042473]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphorylation [GO:0016310]; positive regulation of cyclase activity [GO:0031281]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of xenophagy [GO:1904417]; protein phosphorylation [GO:0006468]; regulation of cellular pH [GO:0030641]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of ossification [GO:0030278]; regulation of stress-activated MAPK cascade [GO:0032872]; response to epidermal growth factor [GO:0070849]; response to exogenous dsRNA [GO:0043330]; sensory perception of pain [GO:0019233]; signal transduction in response to DNA damage [GO:0042770]; stress-activated MAPK cascade [GO:0051403]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]; xenophagy [GO:0098792]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]	ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; phosphatase binding [GO:0019902]; phosphotyrosine residue binding [GO:0001784]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; phosphatase binding [GO:0019902]; phosphotyrosine residue binding [GO:0001784]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; Bergmann glial cell differentiation [GO:0060020]; BMP signaling pathway [GO:0030509]; cardiac neural crest cell development involved in heart development [GO:0061308]; cartilage development [GO:0051216]; caveolin-mediated endocytosis [GO:0072584]; cell cycle [GO:0007049]; cellular response to amino acid starvation [GO:0034198]; cellular response to cadmium ion [GO:0071276]; cellular response to mechanical stimulus [GO:0071260]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; DNA-templated transcription [GO:0006351]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; lung morphogenesis [GO:0060425]; MAPK cascade [GO:0000165]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of TORC1 signaling [GO:1904262]; outer ear morphogenesis [GO:0042473]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphorylation [GO:0016310]; positive regulation of cyclase activity [GO:0031281]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of xenophagy [GO:1904417]; protein phosphorylation [GO:0006468]; regulation of cellular pH [GO:0030641]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of ossification [GO:0030278]; regulation of stress-activated MAPK cascade [GO:0032872]; response to epidermal growth factor [GO:0070849]; response to exogenous dsRNA [GO:0043330]; sensory perception of pain [GO:0019233]; signal transduction in response to DNA damage [GO:0042770]; stress-activated MAPK cascade [GO:0051403]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]; xenophagy [GO:0098792]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P21708}. Nucleus. Membrane, caveola {ECO:0000250|UniProtKB:P21708}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q63844}. Note=Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q63844, ECO:0000269|PubMed:19060905}.
P27448	reviewed	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)	MARK3 CTAK1 EMK2	Homo sapiens (Human)	753	FUNCTION: Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}.		intracellular signal transduction [GO:0035556]; negative regulation of hippo signaling [GO:0035331]; negative regulation of protein localization to nucleus [GO:1900181]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of protein binding [GO:0032092]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; intracellular signal transduction [GO:0035556]; negative regulation of hippo signaling [GO:0035331]; negative regulation of protein localization to nucleus [GO:1900181]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of protein binding [GO:0032092]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:21145462}. Cell projection, dendrite {ECO:0000269|PubMed:23666762}. Cytoplasm {ECO:0000269|PubMed:23666762}.
P27449	reviewed	VATL_HUMAN	V-type proton ATPase 16 kDa proteolipid subunit c (V-ATPase 16 kDa proteolipid subunit c) (Vacuolar proton pump 16 kDa proteolipid subunit c)	ATP6V0C ATP6C ATP6L ATPL	Homo sapiens (Human)	155	FUNCTION: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). {ECO:0000250|UniProtKB:P23956, ECO:0000269|PubMed:33065002}.		endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; positive regulation of Wnt signaling pathway [GO:0030177]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; vacuolar acidification [GO:0007035]	azurophil granule membrane [GO:0035577]; clathrin-coated vesicle membrane [GO:0030665]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]; tertiary granule membrane [GO:0070821]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ubiquitin protein ligase binding [GO:0031625]	azurophil granule membrane [GO:0035577]; clathrin-coated vesicle membrane [GO:0030665]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]; tertiary granule membrane [GO:0070821]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ubiquitin protein ligase binding [GO:0031625]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; positive regulation of Wnt signaling pathway [GO:0030177]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P63081}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P63081}; Multi-pass membrane protein {ECO:0000255}.
P27469	reviewed	G0S2_HUMAN	G0/G1 switch protein 2 (G0/G1 switch regulatory protein 2) (Putative lymphocyte G0/G1 switch gene)	G0S2	Homo sapiens (Human)	103	FUNCTION: Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. {ECO:0000269|PubMed:19706769}.		extrinsic apoptotic signaling pathway [GO:0097191]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]	lipid droplet [GO:0005811]; mitochondrion [GO:0005739]		lipid droplet [GO:0005811]; mitochondrion [GO:0005739]; extrinsic apoptotic signaling pathway [GO:0097191]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19706769}.
P27487	reviewed	DPP4_HUMAN	Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]	DPP4 ADCP2 CD26	Homo sapiens (Human)	766	FUNCTION: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:14691230). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed:16651416, PubMed:10593948). May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed:18708048). When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790). Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 (PubMed:16254193, PubMed:10570924). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed:10593948). {ECO:0000269|PubMed:10570924, ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:14691230, ECO:0000269|PubMed:16254193, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:17549790, ECO:0000269|PubMed:18708048}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2. {ECO:0000269|PubMed:23835475}.	MISCELLANEOUS: Level of plasma concentrations of the soluble form (SDPP) can be managed as a colon carcinoma diagnostic and prognostic marker.	behavioral fear response [GO:0001662]; cell adhesion [GO:0007155]; endothelial cell migration [GO:0043542]; glucagon processing [GO:0120116]; locomotory exploration behavior [GO:0035641]; membrane fusion [GO:0061025]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of neutrophil chemotaxis [GO:0090024]; peptide hormone processing [GO:0016486]; positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; psychomotor behavior [GO:0036343]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; receptor-mediated virion attachment to host cell [GO:0046813]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; response to hypoxia [GO:0001666]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; viral entry into host cell [GO:0046718]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; intercellular canaliculus [GO:0046581]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	aminopeptidase activity [GO:0004177]; chemorepellent activity [GO:0045499]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; intercellular canaliculus [GO:0046581]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; aminopeptidase activity [GO:0004177]; chemorepellent activity [GO:0045499]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618]; behavioral fear response [GO:0001662]; cell adhesion [GO:0007155]; endothelial cell migration [GO:0043542]; glucagon processing [GO:0120116]; locomotory exploration behavior [GO:0035641]; membrane fusion [GO:0061025]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of neutrophil chemotaxis [GO:0090024]; peptide hormone processing [GO:0016486]; positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; psychomotor behavior [GO:0036343]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; receptor-mediated virion attachment to host cell [GO:0046813]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; response to hypoxia [GO:0001666]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: [Dipeptidyl peptidase 4 soluble form]: Secreted {ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:16254193}. Note=Detected in the serum and the seminal fluid. {ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:16254193}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:11772392, ECO:0000305|PubMed:8101391}; Single-pass type II membrane protein. Apical cell membrane {ECO:0000269|PubMed:11773049}; Single-pass type II membrane protein. Cell projection, invadopodium membrane {ECO:0000269|PubMed:16651416}; Single-pass type II membrane protein. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16651416}; Single-pass type II membrane protein. Cell junction {ECO:0000269|PubMed:11772392}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids (PubMed:11773049). Redistributed to membrane rafts in T-cell in an interleukin-12-dependent activation (PubMed:12676959). Its interaction with CAV1 is necessary for its translocation to membrane rafts (PubMed:17287217). Colocalized with PTPRC in membrane rafts (PubMed:12676959). Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma (PubMed:16651416). Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion (PubMed:11772392). Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:11773049, ECO:0000269|PubMed:12676959, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17287217}.
P27539	reviewed	GDF1_HUMAN	Embryonic growth/differentiation factor 1 (GDF-1)	GDF1	Homo sapiens (Human)	372	FUNCTION: May mediate cell differentiation events during embryonic development.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the CERS1 protein from a non-overlapping reading frame.		extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]	SUBCELLULAR LOCATION: Secreted.
P27540	reviewed	ARNT_HUMAN	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)	ARNT BHLHE2	Homo sapiens (Human)	789	FUNCTION: Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). {ECO:0000250|UniProtKB:P53762, ECO:0000269|PubMed:28396409, ECO:0000269|PubMed:34521881, ECO:0000305|PubMed:34521881}.		cell differentiation [GO:0030154]; embryonic placenta development [GO:0001892]; negative regulation of inflammatory response [GO:0050728]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of glycolytic process [GO:0045821]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619]; response to hypoxia [GO:0001666]	aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear aryl hydrocarbon receptor complex [GO:0034753]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	aryl hydrocarbon receptor binding [GO:0017162]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear aryl hydrocarbon receptor complex [GO:0034753]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; aryl hydrocarbon receptor binding [GO:0017162]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; embryonic placenta development [GO:0001892]; negative regulation of inflammatory response [GO:0050728]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of glycolytic process [GO:0045821]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:34521881}.
P27544	reviewed	CERS1_HUMAN	Ceramide synthase 1 (CerS1) (LAG1 longevity assurance homolog 1) (Longevity assurance gene 1 protein homolog 1) (Protein UOG-1) (Sphingoid base N-stearoyltransferase CERS1) (EC 2.3.1.299)	CERS1 LAG1 LASS1 UOG1	Homo sapiens (Human)	350	FUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA) (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624, PubMed:24782409). Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity. Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21-dependent way (By similarity). Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function (By similarity). In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging. Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria (PubMed:22922758). {ECO:0000250|UniProtKB:P27545, ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:22922758, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:24782409, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:31916624}.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame. {ECO:0000269|PubMed:2034669}.	cellular response to dithiothreitol [GO:0072721]; cellular response to mycotoxin [GO:0036146]; cellular response to UV-A [GO:0071492]; cellular response to xenobiotic stimulus [GO:0071466]; ceramide biosynthetic process [GO:0046513]; negative regulation of telomerase activity [GO:0051974]; positive regulation of mitophagy [GO:1901526]; sphingolipid biosynthetic process [GO:0030148]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	sphingosine N-acyltransferase activity [GO:0050291]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; sphingosine N-acyltransferase activity [GO:0050291]; cellular response to dithiothreitol [GO:0072721]; cellular response to mycotoxin [GO:0036146]; cellular response to UV-A [GO:0071492]; cellular response to xenobiotic stimulus [GO:0071466]; ceramide biosynthetic process [GO:0046513]; negative regulation of telomerase activity [GO:0051974]; positive regulation of mitophagy [GO:1901526]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24782409}; Multi-pass membrane protein {ECO:0000255}.
P27635	reviewed	RL10_HUMAN	Large ribosomal subunit protein uL16 (60S ribosomal protein L10) (Laminin receptor homolog) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM)	RPL10 DXS648E QM	Homo sapiens (Human)	214	FUNCTION: Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788). {ECO:0000269|PubMed:25316788, ECO:0000269|PubMed:26290468, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; embryonic brain development [GO:1990403]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of translation [GO:0006417]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182]; cytoplasmic translation [GO:0002181]; embryonic brain development [GO:1990403]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of translation [GO:0006417]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6ZWV3}.
P27658	reviewed	CO8A1_HUMAN	Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin]	COL8A1 C3orf7	Homo sapiens (Human)	744	FUNCTION: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. {ECO:0000269|PubMed:11708810}.; FUNCTION: Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis. {ECO:0000269|PubMed:11708810}.	MISCELLANEOUS: Four consecutive Gly-Pro-Pro triplets are present at the C-terminus of the triple-helical region. These may provide the high thermal stability of this region.	angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]	collagen type VIII trimer [GO:0005591]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen type VIII trimer [GO:0005591]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
P27694	reviewed	RFA1_HUMAN	Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]	RPA1 REPA1 RPA70	Homo sapiens (Human)	616	FUNCTION: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:27723720, PubMed:27723717). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}.		base-excision repair [GO:0006284]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via homologous recombination [GO:0000724]; meiotic cell cycle [GO:0051321]; mismatch repair [GO:0006298]; nucleotide-excision repair [GO:0006289]; protein localization to chromosome [GO:0034502]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]	chromosome, telomeric region [GO:0000781]; DNA replication factor A complex [GO:0005662]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of DNA damage [GO:0090734]	damaged DNA binding [GO:0003684]; G-rich strand telomeric DNA binding [GO:0098505]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; single-stranded telomeric DNA binding [GO:0043047]	chromosome, telomeric region [GO:0000781]; DNA replication factor A complex [GO:0005662]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of DNA damage [GO:0090734]; damaged DNA binding [GO:0003684]; G-rich strand telomeric DNA binding [GO:0098505]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; single-stranded telomeric DNA binding [GO:0043047]; base-excision repair [GO:0006284]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via homologous recombination [GO:0000724]; meiotic cell cycle [GO:0051321]; mismatch repair [GO:0006298]; nucleotide-excision repair [GO:0006289]; protein localization to chromosome [GO:0034502]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17959650}. Nucleus, PML body {ECO:0000269|PubMed:17959650}. Note=Enriched in PML bodies in cells displaying alternative lengthening of their telomeres. {ECO:0000269|PubMed:17959650}.
P27695	reviewed	APEX1_HUMAN	DNA-(apurinic or apyrimidinic site) endonuclease (EC 3.1.11.2) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial]	APEX1 APE APE1 APEX APX HAP1 REF1	Homo sapiens (Human)	318	FUNCTION: Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA. {ECO:0000269|PubMed:10023679, ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:11452037, ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:11832948, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:16617147, ECO:0000269|PubMed:1719477, ECO:0000269|PubMed:18179823, ECO:0000269|PubMed:18439621, ECO:0000269|PubMed:18579163, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:19401441, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20699270, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21762700, ECO:0000269|PubMed:8355688, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:8932375, ECO:0000269|PubMed:9108029, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9560228, ECO:0000269|PubMed:9804799}.	MISCELLANEOUS: Extract of mitochondria, but not of nuclei or cytosol, cleaves recombinant APEX1 to generate a mitochondrial APEX1-sized product (By similarity). The specific activity of the cleaved mitochondrial endodeoxyribonuclease appeared to be about 3-fold higher than that of the full-length form. {ECO:0000250}.	base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; cell redox homeostasis [GO:0045454]; DNA catabolic process [GO:0006308]; DNA demethylation [GO:0080111]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of mRNA stability [GO:0043488]; telomere maintenance [GO:0000723]; telomere maintenance via base-excision repair [GO:0097698]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]	3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; chromatin DNA binding [GO:0031490]; class II DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0052720]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA-(abasic site) binding [GO:0140431]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; double-stranded DNA exodeoxyribonuclease activity [GO:0008309]; double-stranded telomeric DNA binding [GO:0003691]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands [GO:0090580]; phosphodiesterase I activity [GO:0004528]; phosphoric diester hydrolase activity [GO:0008081]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; uracil DNA N-glycosylase activity [GO:0004844]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]; 3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; chromatin DNA binding [GO:0031490]; class II DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0052720]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA-(abasic site) binding [GO:0140431]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; double-stranded DNA exodeoxyribonuclease activity [GO:0008309]; double-stranded telomeric DNA binding [GO:0003691]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands [GO:0090580]; phosphodiesterase I activity [GO:0004528]; phosphoric diester hydrolase activity [GO:0008081]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; uracil DNA N-glycosylase activity [GO:0004844]; base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; cell redox homeostasis [GO:0045454]; DNA catabolic process [GO:0006308]; DNA demethylation [GO:0080111]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of mRNA stability [GO:0043488]; telomere maintenance [GO:0000723]; telomere maintenance via base-excision repair [GO:0097698]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00764}. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm. Note=Detected in the cytoplasm of B-cells stimulated to switch (By similarity). Colocalized with SIRT1 in the nucleus. Colocalized with YBX1 in nuclear speckles after genotoxic stress. Together with OGG1 is recruited to nuclear speckles in UVA-irradiated cells. Colocalized with nucleolin and NPM1 in the nucleolus. Its nucleolar localization is cell cycle dependent and requires active rRNA transcription. Colocalized with calreticulin in the endoplasmic reticulum. Translocation from the nucleus to the cytoplasm is stimulated in presence of nitric oxide (NO) and function in a CRM1-dependent manner, possibly as a consequence of demasking a nuclear export signal (amino acid position 64-80). S-nitrosylation at Cys-93 and Cys-310 regulates its nuclear-cytosolic shuttling. Ubiquitinated form is localized predominantly in the cytoplasm. {ECO:0000250}.; SUBCELLULAR LOCATION: [DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial]: Mitochondrion. Note=The cleaved APEX2 is only detected in mitochondria (By similarity). Translocation from the cytoplasm to the mitochondria is mediated by ROS signaling and cleavage mediated by granzyme A. Tom20-dependent translocated mitochondrial APEX1 level is significantly increased after genotoxic stress. {ECO:0000250}.
P27701	reviewed	CD82_HUMAN	CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82)	CD82 KAI1 SAR2 ST6 TSPAN27	Homo sapiens (Human)	267	FUNCTION: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.			extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]		extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30463011}; Multi-pass membrane protein {ECO:0000255}.
P27707	reviewed	DCK_HUMAN	Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113)	DCK	Homo sapiens (Human)	260	FUNCTION: Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:1996353, PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445). {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:1996353, ECO:0000269|PubMed:20614893, ECO:0000269|PubMed:20637175}.		dAMP salvage [GO:0106383]; nucleoside phosphate biosynthetic process [GO:1901293]; phosphorylation [GO:0016310]; pyrimidine nucleotide metabolic process [GO:0006220]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; deoxyadenosine kinase activity [GO:0004136]; deoxycytidine kinase activity [GO:0004137]; deoxyguanosine kinase activity [GO:0004138]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; deoxyadenosine kinase activity [GO:0004136]; deoxycytidine kinase activity [GO:0004137]; deoxyguanosine kinase activity [GO:0004138]; protein homodimerization activity [GO:0042803]; dAMP salvage [GO:0106383]; nucleoside phosphate biosynthetic process [GO:1901293]; phosphorylation [GO:0016310]; pyrimidine nucleotide metabolic process [GO:0006220]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9342341}.
P27708	reviewed	PYR1_HUMAN	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]	CAD	Homo sapiens (Human)	2225	FUNCTION: This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). {ECO:0000269|PubMed:24332717}.	MISCELLANEOUS: GATase (glutamine amidotransferase) and CPSase (carbamoyl phosphate synthase) form together the glutamine-dependent CPSase (GD-CPSase) (EC 6.3.5.5). {ECO:0000305}.	'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; animal organ regeneration [GO:0031100]; cellular response to epidermal growth factor stimulus [GO:0071364]; citrulline biosynthetic process [GO:0019240]; female pregnancy [GO:0007565]; glutamine metabolic process [GO:0006541]; heart development [GO:0007507]; lactation [GO:0007595]; liver development [GO:0001889]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; response to amine [GO:0014075]; response to caffeine [GO:0031000]; response to cortisol [GO:0051414]; response to insulin [GO:0032868]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]; UDP biosynthetic process [GO:0006225]; UTP biosynthetic process [GO:0006228]; xenobiotic metabolic process [GO:0006805]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; terminal bouton [GO:0043195]	aspartate binding [GO:0070335]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; dihydroorotase activity [GO:0004151]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; zinc ion binding [GO:0008270]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; terminal bouton [GO:0043195]; aspartate binding [GO:0070335]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; dihydroorotase activity [GO:0004151]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; zinc ion binding [GO:0008270]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; animal organ regeneration [GO:0031100]; cellular response to epidermal growth factor stimulus [GO:0071364]; citrulline biosynthetic process [GO:0019240]; female pregnancy [GO:0007565]; glutamine metabolic process [GO:0006541]; heart development [GO:0007507]; lactation [GO:0007595]; liver development [GO:0001889]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; response to amine [GO:0014075]; response to caffeine [GO:0031000]; response to cortisol [GO:0051414]; response to insulin [GO:0032868]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]; UDP biosynthetic process [GO:0006225]; UTP biosynthetic process [GO:0006228]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15890648}. Nucleus {ECO:0000269|PubMed:15890648}. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.
P27797	reviewed	CALR_HUMAN	Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)	CALR CRTC	Homo sapiens (Human)	417	FUNCTION: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}.		cardiac muscle cell differentiation [GO:0055007]; cellular response to electrical stimulus [GO:0071257]; cellular response to lithium ion [GO:0071285]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; cortical actin cytoskeleton organization [GO:0030866]; glucocorticoid receptor signaling pathway [GO:0042921]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; negative regulation of trophoblast cell migration [GO:1901164]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phagocytosis [GO:0050766]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein export from nucleus [GO:0006611]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein localization to nucleus [GO:0034504]; protein maturation by protein folding [GO:0022417]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; regulation of meiotic nuclear division [GO:0040020]; response to estradiol [GO:0032355]; response to glycoside [GO:1903416]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; selective autophagy [GO:0061912]; sequestering of calcium ion [GO:0051208]; spermatogenesis [GO:0007283]; ubiquitin-dependent ERAD pathway [GO:0030433]	acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cortical granule [GO:0060473]; cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; polysome [GO:0005844]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; complement component C1q complex binding [GO:0001849]; DNA binding [GO:0003677]; hormone binding [GO:0042562]; integrin binding [GO:0005178]; iron ion binding [GO:0005506]; mRNA binding [GO:0003729]; nuclear androgen receptor binding [GO:0050681]; nuclear export signal receptor activity [GO:0005049]; peptide binding [GO:0042277]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]	acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cortical granule [GO:0060473]; cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; polysome [GO:0005844]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; complement component C1q complex binding [GO:0001849]; DNA binding [GO:0003677]; hormone binding [GO:0042562]; integrin binding [GO:0005178]; iron ion binding [GO:0005506]; mRNA binding [GO:0003729]; nuclear androgen receptor binding [GO:0050681]; nuclear export signal receptor activity [GO:0005049]; peptide binding [GO:0042277]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]; cardiac muscle cell differentiation [GO:0055007]; cellular response to electrical stimulus [GO:0071257]; cellular response to lithium ion [GO:0071285]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; cortical actin cytoskeleton organization [GO:0030866]; glucocorticoid receptor signaling pathway [GO:0042921]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; negative regulation of trophoblast cell migration [GO:1901164]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phagocytosis [GO:0050766]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein export from nucleus [GO:0006611]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein localization to nucleus [GO:0034504]; protein maturation by protein folding [GO:0022417]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; regulation of meiotic nuclear division [GO:0040020]; response to estradiol [GO:0032355]; response to glycoside [GO:1903416]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; selective autophagy [GO:0061912]; sequestering of calcium ion [GO:0051208]; spermatogenesis [GO:0007283]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:10358038, ECO:0000269|PubMed:11149926}. Cytoplasm, cytosol {ECO:0000269|PubMed:11149926}. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Cell surface {ECO:0000269|PubMed:10358038}. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P28491}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8K3H7}. Cytolytic granule {ECO:0000269|PubMed:8418194}. Note=Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038). During oocyte maturation and after parthenogenetic activation accumulates in cortical granules. In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity). In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:8418194}.
P27815	reviewed	PDE4A_HUMAN	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46)	PDE4A DPDE2	Homo sapiens (Human)	886	FUNCTION: Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Probably represents a non-functional splice isoform. {ECO:0000305}.	cAMP catabolic process [GO:0006198]; cellular response to xenobiotic stimulus [GO:0071466]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106070]; regulation of protein kinase A signaling [GO:0010738]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; cAMP binding [GO:0030552]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; cAMP binding [GO:0030552]; metal ion binding [GO:0046872]; cAMP catabolic process [GO:0006198]; cellular response to xenobiotic stimulus [GO:0071466]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106070]; regulation of protein kinase A signaling [GO:0010738]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15738310}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15738310}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15738310}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol {ECO:0000269|PubMed:7888306}.; SUBCELLULAR LOCATION: [Isoform 4]: Membrane; Peripheral membrane protein {ECO:0000269|PubMed:9677330}. Note=Isoform 4 has propensity for association with membranes. {ECO:0000269|PubMed:9677330}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm, cytosol. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:18095939}. Note=Predominantly cytosolic. {ECO:0000269|PubMed:18095939}.
P27816	reviewed	MAP4_HUMAN	Microtubule-associated protein 4 (MAP-4)	MAP4	Homo sapiens (Human)	1152	FUNCTION: Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell division [GO:0051301]; cilium disassembly [GO:0061523]; establishment of spindle orientation [GO:0051294]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; microtubule sliding [GO:0051012]; mitotic spindle organization [GO:0007052]; negative regulation of non-motile cilium assembly [GO:1902856]; neuron projection development [GO:0031175]	axon [GO:0030424]; axoneme [GO:0005930]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	microtubule binding [GO:0008017]; microtubule stabilizing activity [GO:0140778]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]	axon [GO:0030424]; axoneme [GO:0005930]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; microtubule binding [GO:0008017]; microtubule stabilizing activity [GO:0140778]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; cell division [GO:0051301]; cilium disassembly [GO:0061523]; establishment of spindle orientation [GO:0051294]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; microtubule sliding [GO:0051012]; mitotic spindle organization [GO:0007052]; negative regulation of non-motile cilium assembly [GO:1902856]; neuron projection development [GO:0031175]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:34782749}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:29180244}. Note=Recruitment to microtubule is inhibited by microtubules polyglutamylation. {ECO:0000269|PubMed:34782749}.
P27824	reviewed	CALX_HUMAN	Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)	CANX	Homo sapiens (Human)	592	FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.		clathrin-dependent endocytosis [GO:0072583]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein secretion [GO:0009306]; synaptic vesicle endocytosis [GO:0048488]; ubiquitin-dependent ERAD pathway [GO:0030433]; viral protein processing [GO:0019082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; extracellular exosome [GO:0070062]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; nuclear membrane [GO:0031965]; presynapse [GO:0098793]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; extracellular exosome [GO:0070062]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; nuclear membrane [GO:0031965]; presynapse [GO:0098793]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; clathrin-dependent endocytosis [GO:0072583]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein secretion [GO:0009306]; synaptic vesicle endocytosis [GO:0048488]; ubiquitin-dependent ERAD pathway [GO:0030433]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22314232}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:22314232}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232). {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:22314232}.
P27918	reviewed	PROP_HUMAN	Properdin (Complement factor P)	CFP PFC	Homo sapiens (Human)	469	FUNCTION: A positive regulator of the alternate pathway (AP) of complement (PubMed:20382442, PubMed:28264884). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed:20382442, PubMed:28264884). Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed:31507604). {ECO:0000269|PubMed:20382442, ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604}.		complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; defense response to bacterium [GO:0042742]; immune response [GO:0006955]; positive regulation of immune response [GO:0050778]; positive regulation of opsonization [GO:1903028]	cytoplasmic side of Golgi membrane [GO:0098548]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]		cytoplasmic side of Golgi membrane [GO:0098548]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; defense response to bacterium [GO:0042742]; immune response [GO:0006955]; positive regulation of immune response [GO:0050778]; positive regulation of opsonization [GO:1903028]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604}.
P27930	reviewed	IL1R2_HUMAN	Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)]	IL1R2 IL1RB	Homo sapiens (Human)	398	FUNCTION: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269|PubMed:10975853, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9862719}.		immune response [GO:0006955]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of protein processing [GO:0010955]; protein processing [GO:0016485]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	interleukin-1 binding [GO:0019966]; interleukin-1 receptor activity [GO:0004908]; interleukin-1, type II, blocking receptor activity [GO:0004910]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; interleukin-1 binding [GO:0019966]; interleukin-1 receptor activity [GO:0004908]; interleukin-1, type II, blocking receptor activity [GO:0004910]; immune response [GO:0006955]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of protein processing [GO:0010955]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: [Isoform Short]: Secreted {ECO:0000269|PubMed:8702856}.; SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane; Single-pass type I membrane protein.
P27986	reviewed	P85A_HUMAN	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)	PIK3R1 GRB1	Homo sapiens (Human)	724	FUNCTION: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}.		B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cellular response to UV [GO:0034644]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; growth hormone receptor signaling pathway [GO:0060396]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular glucose homeostasis [GO:0001678]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; myeloid leukocyte migration [GO:0097529]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of stress fiber assembly [GO:0051497]; osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of glucose import [GO:0046326]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of RNA splicing [GO:0033120]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of phosphatidylinositol 3-kinase activity [GO:0043551]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; response to endoplasmic reticulum stress [GO:0034976]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]	cell-cell junction [GO:0005911]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum membrane [GO:1990578]; perinuclear region of cytoplasm [GO:0048471]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; ErbB-3 class receptor binding [GO:0043125]; insulin binding [GO:0043559]; insulin receptor binding [GO:0005158]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor receptor binding [GO:0005159]; kinase activator activity [GO:0019209]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphatidylinositol kinase activity [GO:0052742]; phosphotyrosine residue binding [GO:0001784]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	cell-cell junction [GO:0005911]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum membrane [GO:1990578]; perinuclear region of cytoplasm [GO:0048471]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; ErbB-3 class receptor binding [GO:0043125]; insulin binding [GO:0043559]; insulin receptor binding [GO:0005158]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor receptor binding [GO:0005159]; kinase activator activity [GO:0019209]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphatidylinositol kinase activity [GO:0052742]; phosphotyrosine residue binding [GO:0001784]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cellular response to UV [GO:0034644]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; growth hormone receptor signaling pathway [GO:0060396]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular glucose homeostasis [GO:0001678]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; myeloid leukocyte migration [GO:0097529]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of stress fiber assembly [GO:0051497]; osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of glucose import [GO:0046326]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of RNA splicing [GO:0033120]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of phosphatidylinositol 3-kinase activity [GO:0043551]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; response to endoplasmic reticulum stress [GO:0034976]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]	
P27987	reviewed	IP3KB_HUMAN	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B)	ITPKB	Homo sapiens (Human)	946	FUNCTION: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}.		cell surface receptor signaling pathway [GO:0007166]; cellular response to calcium ion [GO:0071277]; common myeloid progenitor cell proliferation [GO:0035726]; inositol phosphate biosynthetic process [GO:0032958]; inositol trisphosphate metabolic process [GO:0032957]; MAPK cascade [GO:0000165]; myeloid cell homeostasis [GO:0002262]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of neutrophil apoptotic process [GO:0033030]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of Ras protein signal transduction [GO:0046579]; positive thymic T cell selection [GO:0045059]; regulation of protein phosphorylation [GO:0001932]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]; cell surface receptor signaling pathway [GO:0007166]; cellular response to calcium ion [GO:0071277]; common myeloid progenitor cell proliferation [GO:0035726]; inositol phosphate biosynthetic process [GO:0032958]; inositol trisphosphate metabolic process [GO:0032957]; MAPK cascade [GO:0000165]; myeloid cell homeostasis [GO:0002262]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of neutrophil apoptotic process [GO:0033030]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of Ras protein signal transduction [GO:0046579]; positive thymic T cell selection [GO:0045059]; regulation of protein phosphorylation [GO:0001932]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12747803}. Cytoplasm {ECO:0000269|PubMed:12747803}. Endoplasmic reticulum {ECO:0000269|PubMed:12747803}.
P28039	reviewed	AOAH_HUMAN	Acyloxyacyl hydrolase (EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit]	AOAH	Homo sapiens (Human)	575	FUNCTION: Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145, PubMed:29343645). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity). {ECO:0000250|UniProtKB:O35298, ECO:0000269|PubMed:1883828, ECO:0000269|PubMed:29343645, ECO:0000269|PubMed:8089145}.		fatty acid metabolic process [GO:0006631]; lipopolysaccharide catabolic process [GO:0009104]; negative regulation of inflammatory response [GO:0050728]	cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]	acyloxyacyl hydrolase activity [GO:0050528]; calcium ion binding [GO:0005509]	cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; acyloxyacyl hydrolase activity [GO:0050528]; calcium ion binding [GO:0005509]; fatty acid metabolic process [GO:0006631]; lipopolysaccharide catabolic process [GO:0009104]; negative regulation of inflammatory response [GO:0050728]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8089145, ECO:0000305|PubMed:1883828}. Cytoplasmic vesicle {ECO:0000269|PubMed:8089145}. Note=Detected in urine. {ECO:0000250|UniProtKB:O35298}.
P28062	reviewed	PSB8_HUMAN	Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein)	PSMB8 LMP7 PSMB5i RING10 Y2	Homo sapiens (Human)	276	FUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119). Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. {ECO:0000269|PubMed:16423992, ECO:0000269|PubMed:19443843, ECO:0000269|PubMed:21881205, ECO:0000269|PubMed:27049119, ECO:0000269|PubMed:8163024}.		antigen processing and presentation [GO:0019882]; fat cell differentiation [GO:0045444]; proteasomal protein catabolic process [GO:0010498]; regulation of endopeptidase activity [GO:0052548]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; spermatoproteasome complex [GO:1990111]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; spermatoproteasome complex [GO:1990111]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; antigen processing and presentation [GO:0019882]; fat cell differentiation [GO:0045444]; proteasomal protein catabolic process [GO:0010498]; regulation of endopeptidase activity [GO:0052548]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
P28065	reviewed	PSB9_HUMAN	Proteasome subunit beta type-9 (EC 3.4.25.1) (Low molecular mass protein 2) (Macropain chain 7) (Multicatalytic endopeptidase complex chain 7) (Proteasome chain 7) (Proteasome subunit beta-1i) (Really interesting new gene 12 protein)	PSMB9 LMP2 PSMB6i RING12	Homo sapiens (Human)	219	FUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. {ECO:0000269|PubMed:8163024}.	MISCELLANEOUS: Encoded in the MHC class II region.; MISCELLANEOUS: A model for self-activation in which residue Thr-21 serves as nucleophile and Lys-53 as proton donor/acceptor has been proposed. Subunit processing of mammalian beta-subunits proceeds via a novel ordered two-step mechanism involving autocatalysis.	immune system process [GO:0002376]; proteasomal protein catabolic process [GO:0010498]; regulation of cysteine-type endopeptidase activity [GO:2000116]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; spermatoproteasome complex [GO:1990111]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; spermatoproteasome complex [GO:1990111]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; immune system process [GO:0002376]; proteasomal protein catabolic process [GO:0010498]; regulation of cysteine-type endopeptidase activity [GO:2000116]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
P28066	reviewed	PSA5_HUMAN	Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain)	PSMA5	Homo sapiens (Human)	241	FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; secretory granule lumen [GO:0034774]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; secretory granule lumen [GO:0034774]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
P28067	reviewed	DMA_HUMAN	HLA class II histocompatibility antigen, DM alpha chain (MHC class II antigen DMA) (Really interesting new gene 6 protein)	HLA-DMA DMA RING6	Homo sapiens (Human)	261	FUNCTION: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	cell surface [GO:0009986]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]	MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]	cell surface [GO:0009986]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	SUBCELLULAR LOCATION: Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
P28068	reviewed	DMB_HUMAN	HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB) (Really interesting new gene 7 protein)	HLA-DMB DMB RING7	Homo sapiens (Human)	263	FUNCTION: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; MHC class II protein complex assembly [GO:0002399]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001190]; positive regulation of T cell proliferation [GO:0042102]	intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]	MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]	intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; MHC class II protein complex assembly [GO:0002399]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001190]; positive regulation of T cell proliferation [GO:0042102]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Lysosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
P28069	reviewed	PIT1_HUMAN	Pituitary-specific positive transcription factor 1 (PIT-1) (Growth hormone factor 1) (GHF-1)	POU1F1 GHF1 PIT1	Homo sapiens (Human)	291	FUNCTION: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes (PubMed:22010633, PubMed:26612202). {ECO:0000269|PubMed:22010633, ECO:0000269|PubMed:26612202}.	MISCELLANEOUS: [Isoform A]: Altered in its ability to trans-activate compared to isoform B. {ECO:0000305}.	adenohypophysis development [GO:0021984]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; lncRNA binding [GO:0106222]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; lncRNA binding [GO:0106222]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; adenohypophysis development [GO:0021984]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26612202}.
P28070	reviewed	PSB4_HUMAN	Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)	PSMB4 PROS26	Homo sapiens (Human)	264	FUNCTION: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. {ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]	lipopolysaccharide binding [GO:0001530]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; lipopolysaccharide binding [GO:0001530]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
P28072	reviewed	PSB6_HUMAN	Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y)	PSMB6 LMPY Y	Homo sapiens (Human)	239	FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues. {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]	cadherin binding [GO:0045296]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; cadherin binding [GO:0045296]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
P28074	reviewed	PSB5_HUMAN	Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X)	PSMB5 LMPX MB1 X	Homo sapiens (Human)	263	FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:18502982, ECO:0000269|PubMed:18565852, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis [GO:0006508]; response to oxidative stress [GO:0006979]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]	endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; threonine-type endopeptidase activity [GO:0004298]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; threonine-type endopeptidase activity [GO:0004298]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis [GO:0006508]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
P28161	reviewed	GSTM2_HUMAN	Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST class-mu 2) (GSTM2-2)	GSTM2 GST4	Homo sapiens (Human)	218	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). {ECO:0000269|PubMed:16549767, ECO:0000269|PubMed:21046276}.		cellular detoxification of nitrogen compound [GO:0070458]; cellular response to caffeine [GO:0071313]; glutathione metabolic process [GO:0006749]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; nitrobenzene metabolic process [GO:0018916]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809]; relaxation of cardiac muscle [GO:0055119]; xenobiotic catabolic process [GO:0042178]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; sarcoplasmic reticulum [GO:0016529]	enzyme binding [GO:0019899]; fatty acid binding [GO:0005504]; glutathione binding [GO:0043295]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; sarcoplasmic reticulum [GO:0016529]; enzyme binding [GO:0019899]; fatty acid binding [GO:0005504]; glutathione binding [GO:0043295]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; cellular detoxification of nitrogen compound [GO:0070458]; cellular response to caffeine [GO:0071313]; glutathione metabolic process [GO:0006749]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; nitrobenzene metabolic process [GO:0018916]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809]; relaxation of cardiac muscle [GO:0055119]; xenobiotic catabolic process [GO:0042178]	SUBCELLULAR LOCATION: Cytoplasm.
P28221	reviewed	5HT1D_HUMAN	5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D)	HTR1D HTR1DA HTRL	Homo sapiens (Human)	377	FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1652050}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; intestine smooth muscle contraction [GO:0014827]; regulation of behavior [GO:0050795]; regulation of locomotion [GO:0040012]; vasoconstriction [GO:0042310]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; intestine smooth muscle contraction [GO:0014827]; regulation of behavior [GO:0050795]; regulation of locomotion [GO:0040012]; vasoconstriction [GO:0042310]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1652050}; Multi-pass membrane protein {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1652050}.
P28222	reviewed	5HT1B_HUMAN	5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (S12) (Serotonin 1D beta receptor) (5-HT-1D-beta) (Serotonin receptor 1B)	HTR1B HTR1DB	Homo sapiens (Human)	390	FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:15853772, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:8218242}.	MISCELLANEOUS: A residue in the 7th transmembrane region (Thr-355 in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; bone remodeling [GO:0046849]; cellular response to alkaloid [GO:0071312]; cellular response to temperature stimulus [GO:0071502]; cellular response to xenobiotic stimulus [GO:0071466]; chemical synaptic transmission [GO:0007268]; drinking behavior [GO:0042756]; G protein-coupled receptor internalization [GO:0002031]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; negative regulation of serotonin secretion [GO:0014063]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of behavior [GO:0050795]; regulation of dopamine secretion [GO:0014059]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to mineralocorticoid [GO:0051385]; vasoconstriction [GO:0042310]	calyx of Held [GO:0044305]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; G protein-coupled serotonin receptor complex [GO:0098666]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; serotonergic synapse [GO:0099154]	G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626]	calyx of Held [GO:0044305]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; G protein-coupled serotonin receptor complex [GO:0098666]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; serotonergic synapse [GO:0099154]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; bone remodeling [GO:0046849]; cellular response to alkaloid [GO:0071312]; cellular response to temperature stimulus [GO:0071502]; cellular response to xenobiotic stimulus [GO:0071466]; chemical synaptic transmission [GO:0007268]; drinking behavior [GO:0042756]; G protein-coupled receptor internalization [GO:0002031]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; negative regulation of serotonin secretion [GO:0014063]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of behavior [GO:0050795]; regulation of dopamine secretion [GO:0014059]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to mineralocorticoid [GO:0051385]; vasoconstriction [GO:0042310]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}; Multi-pass membrane protein {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}.
P28223	reviewed	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A)	HTR2A HTR2	Homo sapiens (Human)	471	FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. {ECO:0000269|PubMed:1330647, ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:21645528, ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:28129538}.; FUNCTION: (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. {ECO:0000269|PubMed:24089568}.	MISCELLANEOUS: Binds lysergic acid diethylamine (LSD) in the orthosteric pocket (Probable). Bound LSD dissociates extremely slowly, with a residence time of about 221 minutes at 37 degrees Celsius. {ECO:0000269|PubMed:28129538}.	activation of phospholipase C activity [GO:0007202]; artery smooth muscle contraction [GO:0014824]; behavioral response to cocaine [GO:0048148]; chemical synaptic transmission [GO:0007268]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; glycolytic process [GO:0006096]; intracellular calcium ion homeostasis [GO:0006874]; memory [GO:0007613]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glycolytic process [GO:0045821]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; positive regulation of vasoconstriction [GO:0045907]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein localization to cytoskeleton [GO:0044380]; regulation of dopamine secretion [GO:0014059]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; serotonin receptor signaling pathway [GO:0007210]; temperature homeostasis [GO:0001659]; urinary bladder smooth muscle contraction [GO:0014832]	axon [GO:0030424]; caveola [GO:0005901]; cell body fiber [GO:0070852]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; G protein-coupled serotonin receptor complex [GO:0098666]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding [GO:0071886]; G protein-coupled serotonin receptor activity [GO:0004993]; Gq/11-coupled serotonin receptor activity [GO:0001587]; identical protein binding [GO:0042802]; neurotransmitter receptor activity [GO:0030594]; protein tyrosine kinase activator activity [GO:0030296]; protein-containing complex binding [GO:0044877]; serotonin binding [GO:0051378]; virus receptor activity [GO:0001618]	axon [GO:0030424]; caveola [GO:0005901]; cell body fiber [GO:0070852]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; G protein-coupled serotonin receptor complex [GO:0098666]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding [GO:0071886]; G protein-coupled serotonin receptor activity [GO:0004993]; Gq/11-coupled serotonin receptor activity [GO:0001587]; identical protein binding [GO:0042802]; neurotransmitter receptor activity [GO:0030594]; protein tyrosine kinase activator activity [GO:0030296]; protein-containing complex binding [GO:0044877]; serotonin binding [GO:0051378]; virus receptor activity [GO:0001618]; activation of phospholipase C activity [GO:0007202]; artery smooth muscle contraction [GO:0014824]; behavioral response to cocaine [GO:0048148]; chemical synaptic transmission [GO:0007268]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; glycolytic process [GO:0006096]; intracellular calcium ion homeostasis [GO:0006874]; memory [GO:0007613]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glycolytic process [GO:0045821]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; positive regulation of vasoconstriction [GO:0045907]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein localization to cytoskeleton [GO:0044380]; regulation of dopamine secretion [GO:0014059]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; serotonin receptor signaling pathway [GO:0007210]; temperature homeostasis [GO:0001659]; urinary bladder smooth muscle contraction [GO:0014832]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28129538}; Multi-pass membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:P35363}. Cell projection, axon {ECO:0000250|UniProtKB:P14842}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P14842}. Membrane, caveola {ECO:0000250|UniProtKB:P14842}. Presynapse {ECO:0000250|UniProtKB:P14842}.
P28288	reviewed	ABCD3_HUMAN	ATP-binding cassette sub-family D member 3 (EC 3.1.2.-) (EC 7.6.2.-) (70 kDa peroxisomal membrane protein) (PMP70)	ABCD3 PMP70 PXMP1	Homo sapiens (Human)	659	FUNCTION: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation (PubMed:11248239, PubMed:25168382, PubMed:24333844, PubMed:29397936). Has fatty acyl-CoA thioesterase and ATPase activities (PubMed:29397936). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:25944712, PubMed:24333844). {ECO:0000250|UniProtKB:P33897, ECO:0000269|PubMed:11248239, ECO:0000269|PubMed:24333844, ECO:0000269|PubMed:25168382, ECO:0000269|PubMed:25944712, ECO:0000269|PubMed:29397936}.		bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; fatty acid beta-oxidation [GO:0006635]; fatty acid biosynthetic process [GO:0006633]; long-chain fatty acid import into peroxisome [GO:0015910]; peroxisome organization [GO:0007031]; phytanic acid metabolic process [GO:1903512]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	ABC-type transporter activity [GO:0140359]; acyl-CoA hydrolase activity [GO:0047617]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; long-chain fatty acid transporter activity [GO:0005324]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; ABC-type transporter activity [GO:0140359]; acyl-CoA hydrolase activity [GO:0047617]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; long-chain fatty acid transporter activity [GO:0005324]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]; bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; fatty acid beta-oxidation [GO:0006635]; fatty acid biosynthetic process [GO:0006633]; long-chain fatty acid import into peroxisome [GO:0015910]; peroxisome organization [GO:0007031]; phytanic acid metabolic process [GO:1903512]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:16344115, ECO:0000269|PubMed:17761678, ECO:0000269|PubMed:24333844, ECO:0000269|PubMed:29397936}; Multi-pass membrane protein {ECO:0000255}.
P28289	reviewed	TMOD1_HUMAN	Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)	TMOD1 D9S57E TMOD	Homo sapiens (Human)	359	FUNCTION: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269|PubMed:8002995}.		actin filament organization [GO:0007015]; adult locomotory behavior [GO:0008344]; lens fiber cell development [GO:0070307]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]	actin filament [GO:0005884]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]	actin binding [GO:0003779]; tropomyosin binding [GO:0005523]	actin filament [GO:0005884]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]; actin binding [GO:0003779]; tropomyosin binding [GO:0005523]; actin filament organization [GO:0007015]; adult locomotory behavior [GO:0008344]; lens fiber cell development [GO:0070307]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25250574}. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). {ECO:0000269|PubMed:25250574}.
P28290	reviewed	ITPI2_HUMAN	Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2)	ITPRID2 CS1 KIAA1927 KRAP SSFA2	Homo sapiens (Human)	1259				cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; signaling receptor binding [GO:0005102]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; signaling receptor binding [GO:0005102]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14673706}. Note=Located near the plasma membrane. Associated with actin filaments. May also exist as a membrane-bound form with extracellular regions.
P28300	reviewed	LYOX_HUMAN	Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase) [Cleaved into: Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form]	LOX	Homo sapiens (Human)	417	FUNCTION: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). {ECO:0000250|UniProtKB:P28301, ECO:0000269|PubMed:26838787}.		ascending aorta development [GO:0035905]; blood vessel morphogenesis [GO:0048514]; bone mineralization [GO:0030282]; cell chemotaxis [GO:0060326]; cellular response to chemokine [GO:1990869]; collagen fibril organization [GO:0030199]; connective tissue development [GO:0061448]; descending aorta development [GO:0035906]; DNA biosynthetic process [GO:0071897]; elastic fiber assembly [GO:0048251]; heart development [GO:0007507]; lung development [GO:0030324]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]; osteoblast differentiation [GO:0001649]; peptidyl-lysine oxidation [GO:0018057]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; protein modification process [GO:0036211]; regulation of apoptotic process [GO:0042981]; regulation of bone development [GO:1903010]; regulation of gene expression [GO:0010468]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000586]; regulation of protein phosphorylation [GO:0001932]; regulation of striated muscle tissue development [GO:0016202]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	collagen binding [GO:0005518]; copper ion binding [GO:0005507]; molecular adaptor activity [GO:0060090]; protein-lysine 6-oxidase activity [GO:0004720]; small molecule binding [GO:0036094]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; collagen binding [GO:0005518]; copper ion binding [GO:0005507]; molecular adaptor activity [GO:0060090]; protein-lysine 6-oxidase activity [GO:0004720]; small molecule binding [GO:0036094]; ascending aorta development [GO:0035905]; blood vessel morphogenesis [GO:0048514]; bone mineralization [GO:0030282]; cell chemotaxis [GO:0060326]; cellular response to chemokine [GO:1990869]; collagen fibril organization [GO:0030199]; connective tissue development [GO:0061448]; descending aorta development [GO:0035906]; DNA biosynthetic process [GO:0071897]; elastic fiber assembly [GO:0048251]; heart development [GO:0007507]; lung development [GO:0030324]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]; osteoblast differentiation [GO:0001649]; peptidyl-lysine oxidation [GO:0018057]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; protein modification process [GO:0036211]; regulation of apoptotic process [GO:0042981]; regulation of bone development [GO:1903010]; regulation of gene expression [GO:0010468]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000586]; regulation of protein phosphorylation [GO:0001932]; regulation of striated muscle tissue development [GO:0016202]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31152061}. Secreted, extracellular space.
P28324	reviewed	ELK4_HUMAN	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1)	ELK4 SAP1	Homo sapiens (Human)	431	FUNCTION: Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P28325	reviewed	CYTD_HUMAN	Cystatin-D (Cystatin-5)	CST5	Homo sapiens (Human)	142	FUNCTION: Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. {ECO:0000269|PubMed:8083219}.			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; vesicle [GO:0031982]	cysteine-type endopeptidase inhibitor activity [GO:0004869]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; vesicle [GO:0031982]; cysteine-type endopeptidase inhibitor activity [GO:0004869]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20189825}.
P28328	reviewed	PEX2_HUMAN	Peroxisome biogenesis factor 2 (EC 2.3.2.27) (EC 2.3.2.36) (35 kDa peroxisomal membrane protein) (Peroxin-2) (Peroxisomal membrane protein 3) (Peroxisome assembly factor 1) (PAF-1) (RING finger protein 72)	PEX2 PAF1 PMP3 PMP35 PXMP3 RNF72	Homo sapiens (Human)	305	FUNCTION: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity). PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity). Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70 (PubMed:27597759). Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (PubMed:34903883). {ECO:0000250|UniProtKB:P32800, ECO:0000269|PubMed:24662292, ECO:0000269|PubMed:27597759, ECO:0000269|PubMed:34903883}.		cellular response to reactive oxygen species [GO:0034614]; fatty acid beta-oxidation [GO:0006635]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; peroxisome organization [GO:0007031]; pexophagy [GO:0000425]; protein destabilization [GO:0031648]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein ubiquitination [GO:0016567]; response to amino acid starvation [GO:1990928]; very long-chain fatty acid metabolic process [GO:0000038]	Cdc73/Paf1 complex [GO:0016593]; cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]	protein transmembrane transporter activity [GO:0008320]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	Cdc73/Paf1 complex [GO:0016593]; cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; protein transmembrane transporter activity [GO:0008320]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; cellular response to reactive oxygen species [GO:0034614]; fatty acid beta-oxidation [GO:0006635]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; peroxisome organization [GO:0007031]; pexophagy [GO:0000425]; protein destabilization [GO:0031648]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein ubiquitination [GO:0016567]; response to amino acid starvation [GO:1990928]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:12751901}; Multi-pass membrane protein {ECO:0000255}.
P28329	reviewed	CLAT_HUMAN	Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6)	CHAT	Homo sapiens (Human)	748	FUNCTION: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. {ECO:0000269|PubMed:17144655}.		acetylcholine biosynthetic process [GO:0008292]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter transport [GO:0006836]; phosphatidylcholine biosynthetic process [GO:0006656]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleus [GO:0005634]; synapse [GO:0045202]	choline O-acetyltransferase activity [GO:0004102]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleus [GO:0005634]; synapse [GO:0045202]; choline O-acetyltransferase activity [GO:0004102]; acetylcholine biosynthetic process [GO:0008292]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter transport [GO:0006836]; phosphatidylcholine biosynthetic process [GO:0006656]	
P28330	reviewed	ACADL_HUMAN	Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8)	ACADL	Homo sapiens (Human)	430	FUNCTION: Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (PubMed:8823175, PubMed:21237683). {ECO:0000250|UniProtKB:P15650, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:8823175}.		carnitine catabolic process [GO:0042413]; carnitine metabolic process, CoA-linked [GO:0019254]; cellular lipid catabolic process [GO:0044242]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; long-chain fatty acid catabolic process [GO:0042758]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of fatty acid oxidation [GO:0046322]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of cholesterol metabolic process [GO:0090181]; temperature homeostasis [GO:0001659]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	fatty-acyl-CoA binding [GO:0000062]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; long-chain-acyl-CoA dehydrogenase activity [GO:0004466]; palmitoyl-CoA oxidase activity [GO:0016401]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; fatty-acyl-CoA binding [GO:0000062]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; long-chain-acyl-CoA dehydrogenase activity [GO:0004466]; palmitoyl-CoA oxidase activity [GO:0016401]; carnitine catabolic process [GO:0042413]; carnitine metabolic process, CoA-linked [GO:0019254]; cellular lipid catabolic process [GO:0044242]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; long-chain fatty acid catabolic process [GO:0042758]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of fatty acid oxidation [GO:0046322]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of cholesterol metabolic process [GO:0090181]; temperature homeostasis [GO:0001659]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P15650}.
P28331	reviewed	NDUS1_HUMAN	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 7.1.1.2) (Complex I-75kD) (CI-75kD)	NDUFS1	Homo sapiens (Human)	727	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30879903, PubMed:31557978). Essential for catalysing the entry and efficient transfer of electrons within complex I (PubMed:31557978). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:30879903, PubMed:31557978). {ECO:0000269|PubMed:30879903, ECO:0000269|PubMed:31557978}.		aerobic respiration [GO:0009060]; apoptotic mitochondrial changes [GO:0008637]; ATP metabolic process [GO:0046034]; cellular respiration [GO:0045333]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]; regulation of mitochondrial membrane potential [GO:0051881]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; apoptotic mitochondrial changes [GO:0008637]; ATP metabolic process [GO:0046034]; cellular respiration [GO:0045333]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]; regulation of mitochondrial membrane potential [GO:0051881]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891, ECO:0000305|PubMed:30879903}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15690}; Matrix side {ECO:0000250|UniProtKB:P15690}.
P28332	reviewed	ADH6_HUMAN	Alcohol dehydrogenase 6 (EC 1.1.1.1)	ADH6	Homo sapiens (Human)	368	FUNCTION: Alcohol dehydrogenase (PubMed:1755855). Catalyzes the NAD-dependent oxidation of primary alcohols to the corresponding aldehydes (PubMed:1755855). Oxidizes secondary alcohols to the corresponding ketones (By similarity). {ECO:0000250|UniProtKB:P07327, ECO:0000269|PubMed:1755855}.	MISCELLANEOUS: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.; MISCELLANEOUS: Isoelectric point (pH(I)) is 8.6. {ECO:0000269|PubMed:1755855}.	ethanol oxidation [GO:0006069]; response to ethanol [GO:0045471]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	alcohol dehydrogenase (NAD+) activity [GO:0004022]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; NAD-retinol dehydrogenase activity [GO:0004745]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; alcohol dehydrogenase (NAD+) activity [GO:0004022]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; NAD-retinol dehydrogenase activity [GO:0004745]; zinc ion binding [GO:0008270]; ethanol oxidation [GO:0006069]; response to ethanol [GO:0045471]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]	SUBCELLULAR LOCATION: Cytoplasm.
P28335	reviewed	5HT2C_HUMAN	5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)	HTR2C HTR1C	Homo sapiens (Human)	458	FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}.		behavioral fear response [GO:0001662]; cGMP-mediated signaling [GO:0019934]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; intracellular calcium ion homeostasis [GO:0006874]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; regulation of appetite [GO:0032098]; regulation of corticotropin-releasing hormone secretion [GO:0043397]; regulation of nervous system process [GO:0031644]; release of sequestered calcium ion into cytosol [GO:0051209]	dendrite [GO:0030425]; G protein-coupled serotonin receptor complex [GO:0098666]; plasma membrane [GO:0005886]; synapse [GO:0045202]	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding [GO:0071886]; G protein-coupled serotonin receptor activity [GO:0004993]; Gq/11-coupled serotonin receptor activity [GO:0001587]; identical protein binding [GO:0042802]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]	dendrite [GO:0030425]; G protein-coupled serotonin receptor complex [GO:0098666]; plasma membrane [GO:0005886]; synapse [GO:0045202]; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding [GO:0071886]; G protein-coupled serotonin receptor activity [GO:0004993]; Gq/11-coupled serotonin receptor activity [GO:0001587]; identical protein binding [GO:0042802]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; behavioral fear response [GO:0001662]; cGMP-mediated signaling [GO:0019934]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; intracellular calcium ion homeostasis [GO:0006874]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; regulation of appetite [GO:0032098]; regulation of corticotropin-releasing hormone secretion [GO:0043397]; regulation of nervous system process [GO:0031644]; release of sequestered calcium ion into cytosol [GO:0051209]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}; Multi-pass membrane protein {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}.
P28336	reviewed	NMBR_HUMAN	Neuromedin-B receptor (NMB-R) (Epididymis tissue protein Li 185a) (Neuromedin-B-preferring bombesin receptor)	NMBR	Homo sapiens (Human)	390	FUNCTION: Receptor for neuromedin-B (PubMed:1655761). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity). {ECO:0000250|UniProtKB:O54799, ECO:0000269|PubMed:1655761, ECO:0000269|PubMed:31601264}.		antiviral innate immune response [GO:0140374]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of interleukin-6 production [GO:0032715]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of osteoclast proliferation [GO:0090290]; positive regulation of respiratory gaseous exchange [GO:1903942]; sneeze reflex [GO:0160023]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	bombesin receptor activity [GO:0004946]; neuropeptide receptor activity [GO:0008188]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; bombesin receptor activity [GO:0004946]; neuropeptide receptor activity [GO:0008188]; antiviral innate immune response [GO:0140374]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of interleukin-6 production [GO:0032715]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of osteoclast proliferation [GO:0090290]; positive regulation of respiratory gaseous exchange [GO:1903942]; sneeze reflex [GO:0160023]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
P28340	reviewed	DPOD1_HUMAN	DNA polymerase delta catalytic subunit (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase subunit delta p125)	POLD1 POLD	Homo sapiens (Human)	1107	FUNCTION: As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200, PubMed:24022480). Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites (PubMed:19074196, PubMed:24191025). {ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24022480, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24191025, ECO:0000269|PubMed:24310611}.		base-excision repair, gap-filling [GO:0006287]; cellular response to UV [GO:0034644]; DNA biosynthetic process [GO:0071897]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication proofreading [GO:0045004]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; error-free translesion synthesis [GO:0070987]; fatty acid homeostasis [GO:0055089]; nucleotide-excision repair, DNA gap filling [GO:0006297]; response to UV [GO:0009411]	aggresome [GO:0016235]; cytosol [GO:0005829]; delta DNA polymerase complex [GO:0043625]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634]	3'-5'-DNA exonuclease activity [GO:0008296]; 4 iron, 4 sulfur cluster binding [GO:0051539]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]	aggresome [GO:0016235]; cytosol [GO:0005829]; delta DNA polymerase complex [GO:0043625]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634]; 3'-5'-DNA exonuclease activity [GO:0008296]; 4 iron, 4 sulfur cluster binding [GO:0051539]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; base-excision repair, gap-filling [GO:0006287]; cellular response to UV [GO:0034644]; DNA biosynthetic process [GO:0071897]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication proofreading [GO:0045004]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; error-free translesion synthesis [GO:0070987]; fatty acid homeostasis [GO:0055089]; nucleotide-excision repair, DNA gap filling [GO:0006297]; response to UV [GO:0009411]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:22801543}. Note=Colocalizes with PCNA and POLD3 at S phase replication sites (PubMed:11595739). After UV irradiation, recruited to DNA damage sites within 2 hours, independently on the cell cycle phase, nor on PCNA ubiquitination. This recruitment requires POLD3, PCNA and RFC1-replication factor C complex (PubMed:20227374, PubMed:22801543). {ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:22801543}.
P28347	reviewed	TEAD1_HUMAN	Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13)	TEAD1 TCF13 TEF1	Homo sapiens (Human)	426	FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.		embryonic organ development [GO:0048568]; hippo signaling [GO:0035329]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TEAD-YAP complex [GO:0140552]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TEAD-YAP complex [GO:0140552]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; embryonic organ development [GO:0048568]; hippo signaling [GO:0035329]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P28356	reviewed	HXD9_HUMAN	Homeobox protein Hox-D9 (Homeobox protein Hox-4C) (Homeobox protein Hox-5.2)	HOXD9 HOX4C	Homo sapiens (Human)	352	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		adult locomotory behavior [GO:0008344]; anterior/posterior pattern specification [GO:0009952]; DNA-templated transcription [GO:0006351]; embryonic forelimb morphogenesis [GO:0035115]; embryonic skeletal system morphogenesis [GO:0048704]; hindlimb morphogenesis [GO:0035137]; mammary gland development [GO:0030879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peripheral nervous system neuron development [GO:0048935]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; single fertilization [GO:0007338]; skeletal muscle tissue development [GO:0007519]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; adult locomotory behavior [GO:0008344]; anterior/posterior pattern specification [GO:0009952]; DNA-templated transcription [GO:0006351]; embryonic forelimb morphogenesis [GO:0035115]; embryonic skeletal system morphogenesis [GO:0048704]; hindlimb morphogenesis [GO:0035137]; mammary gland development [GO:0030879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peripheral nervous system neuron development [GO:0048935]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; single fertilization [GO:0007338]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Nucleus.
P28358	reviewed	HXD10_HUMAN	Homeobox protein Hox-D10 (Homeobox protein Hox-4D) (Homeobox protein Hox-4E)	HOXD10 HOX4D HOX4E	Homo sapiens (Human)	340	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		adult locomotory behavior [GO:0008344]; anterior/posterior pattern specification [GO:0009952]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; forelimb morphogenesis [GO:0035136]; hindlimb morphogenesis [GO:0035137]; negative regulation of cell cycle [GO:0045786]; neuromuscular process [GO:0050905]; peripheral nervous system neuron development [GO:0048935]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; single fertilization [GO:0007338]; skeletal muscle tissue development [GO:0007519]; spinal cord motor neuron cell fate specification [GO:0021520]	chromatin [GO:0000785]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; adult locomotory behavior [GO:0008344]; anterior/posterior pattern specification [GO:0009952]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; forelimb morphogenesis [GO:0035136]; hindlimb morphogenesis [GO:0035137]; negative regulation of cell cycle [GO:0045786]; neuromuscular process [GO:0050905]; peripheral nervous system neuron development [GO:0048935]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; single fertilization [GO:0007338]; skeletal muscle tissue development [GO:0007519]; spinal cord motor neuron cell fate specification [GO:0021520]	SUBCELLULAR LOCATION: Nucleus.
P28360	reviewed	MSX1_HUMAN	Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein)	MSX1 HOX7	Homo sapiens (Human)	303	FUNCTION: Acts as a transcriptional repressor (By similarity). Capable of transcription autoinactivation (By similarity). Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (By similarity). Represses transcription of myoblast differentiation factors (By similarity). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (By similarity). Recruits histone H3 methyltransferases such as EHMT2/G9a to gene promoter regions which leads to inhibition of myoblast differentiation via transcriptional repression of differentiation factors (By similarity). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (By similarity). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (By similarity). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (By similarity). Required for BMP4 expression in dental mesenchyme cells (By similarity). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (By similarity). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (By similarity). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (By similarity). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as an homeostatic regulator of the cell cycle (By similarity). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN (By similarity). Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation (By similarity). Plays a role in embryonic bone formation of the middle ear, skull and nasal bones (By similarity). Required for correct formation and thickness of the nail plate (By similarity). May play a role in limb-pattern formation (By similarity). {ECO:0000250|UniProtKB:P13297, ECO:0000269|PubMed:12807959, ECO:0000303|PubMed:8696335}.		activation of meiosis [GO:0090427]; anterior/posterior pattern specification [GO:0009952]; BMP signaling pathway [GO:0030509]; bone morphogenesis [GO:0060349]; cardiac conduction system development [GO:0003161]; cartilage morphogenesis [GO:0060536]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway involved in heart development [GO:0061311]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic morphogenesis [GO:0048598]; embryonic nail plate morphogenesis [GO:0035880]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; in utero embryonic development [GO:0001701]; inner ear development [GO:0048839]; mammary gland epithelium development [GO:0061180]; mesenchymal cell apoptotic process [GO:0097152]; mesenchymal cell proliferation [GO:0010463]; midbrain development [GO:0030901]; middle ear morphogenesis [GO:0042474]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of odontoblast differentiation [GO:1901330]; negative regulation of striated muscle cell differentiation [GO:0051154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nose development [GO:0043584]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of mesenchymal cell apoptotic process [GO:2001055]; positive regulation of odontogenesis [GO:0042482]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; signal transduction involved in regulation of gene expression [GO:0023019]; stem cell differentiation [GO:0048863]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; p53 binding [GO:0002039]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; p53 binding [GO:0002039]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; activation of meiosis [GO:0090427]; anterior/posterior pattern specification [GO:0009952]; BMP signaling pathway [GO:0030509]; bone morphogenesis [GO:0060349]; cardiac conduction system development [GO:0003161]; cartilage morphogenesis [GO:0060536]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway involved in heart development [GO:0061311]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic morphogenesis [GO:0048598]; embryonic nail plate morphogenesis [GO:0035880]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; in utero embryonic development [GO:0001701]; inner ear development [GO:0048839]; mammary gland epithelium development [GO:0061180]; mesenchymal cell apoptotic process [GO:0097152]; mesenchymal cell proliferation [GO:0010463]; midbrain development [GO:0030901]; middle ear morphogenesis [GO:0042474]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of odontoblast differentiation [GO:1901330]; negative regulation of striated muscle cell differentiation [GO:0051154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nose development [GO:0043584]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of mesenchymal cell apoptotic process [GO:2001055]; positive regulation of odontogenesis [GO:0042482]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; signal transduction involved in regulation of gene expression [GO:0023019]; stem cell differentiation [GO:0048863]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P13297}. Note=Interaction with EHMT2/G9a is required for localization to the nuclear periphery (By similarity). Interaction with PIAS1 is required for localization to the nuclear periphery (By similarity). {ECO:0000250|UniProtKB:P13297}.
P28370	reviewed	SMCA1_HUMAN	Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)	SMARCA1 SNF2L SNF2L1	Homo sapiens (Human)	1054	FUNCTION: [Isoform 1]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}.; FUNCTION: [Isoform 2]: Helicase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:15310751, PubMed:14609955, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:15310751, PubMed:14609955, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:15310751, PubMed:14609955, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). {ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:16740656, ECO:0000269|PubMed:28801535}.	MISCELLANEOUS: [Isoform 1]: Inactive as an ATPase due to the presence of exon 13, but retains its ability to correctly fold and incorporate into complexes. {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}.; MISCELLANEOUS: [Isoform 2]: Active as an ATPase due to the absence of exon 13. {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}.	brain development [GO:0007420]; chromatin remodeling [GO:0006338]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	ATPase complex [GO:1904949]; CERF complex [GO:0090537]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]	ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; nucleosome binding [GO:0031491]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	ATPase complex [GO:1904949]; CERF complex [GO:0090537]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]; ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; nucleosome binding [GO:0031491]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; brain development [GO:0007420]; chromatin remodeling [GO:0006338]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus.
P28472	reviewed	GBRB3_HUMAN	Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3)	GABRB3	Homo sapiens (Human)	473	FUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Plays an important role in somatosensation and in the production of antinociception (By similarity). {ECO:0000250|UniProtKB:P63080, ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:18514161, ECO:0000269|PubMed:22243422, ECO:0000269|PubMed:22303015, ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:25489750, ECO:0000269|PubMed:26950270}.		cellular response to histamine [GO:0071420]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; roof of mouth development [GO:0060021]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]	chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; identical protein binding [GO:0042802]; neurotransmitter receptor activity [GO:0030594]	chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; identical protein binding [GO:0042802]; neurotransmitter receptor activity [GO:0030594]; cellular response to histamine [GO:0071420]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; roof of mouth development [GO:0060021]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:24909990}. Cell membrane {ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:18514161, ECO:0000269|PubMed:22243422, ECO:0000269|PubMed:22303015, ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:26950270}; Multi-pass membrane protein {ECO:0000269|PubMed:24909990}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P63079}.
P28476	reviewed	GBRR2_HUMAN	Gamma-aminobutyric acid receptor subunit rho-2 (GABA(A) receptor subunit rho-2) (GABA(C) receptor)	GABRR2	Homo sapiens (Human)	465	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission.	MISCELLANEOUS: [Isoform 2]: Isoform 2 could be translated from an upstream initiator ATG located in frame within the first coding exon. The probability of a signal peptide within this isoform is very low. {ECO:0000305}.	chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; signal transduction [GO:0007165]; visual perception [GO:0007601]	chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594]; protein domain specific binding [GO:0019904]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594]; protein domain specific binding [GO:0019904]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
P28482	reviewed	MK01_HUMAN	Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)	MAPK1 ERK2 PRKM1 PRKM2	Homo sapiens (Human)	360	FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1 and FXR1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). {ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391, ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583, ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:32721402, ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688, ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579, ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692, ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}.; FUNCTION: Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. {ECO:0000269|PubMed:19879846}.		androgen receptor signaling pathway [GO:0030521]; apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; Bergmann glial cell differentiation [GO:0060020]; cardiac neural crest cell development involved in heart development [GO:0061308]; caveolin-mediated endocytosis [GO:0072584]; cell cycle [GO:0007049]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amino acid starvation [GO:0034198]; cellular response to cadmium ion [GO:0071276]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; chemical synaptic transmission [GO:0007268]; chemotaxis [GO:0006935]; cytosine metabolic process [GO:0019858]; DNA damage response [GO:0006974]; ERBB signaling pathway [GO:0038127]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; learning or memory [GO:0007611]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; long-term synaptic potentiation [GO:0060291]; lung morphogenesis [GO:0060425]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of cell differentiation [GO:0045596]; outer ear morphogenesis [GO:0042473]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; progesterone receptor signaling pathway [GO:0050847]; protein phosphorylation [GO:0006468]; regulation of cellular pH [GO:0030641]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of ossification [GO:0030278]; regulation of protein stability [GO:0031647]; regulation of stress-activated MAPK cascade [GO:0032872]; response to epidermal growth factor [GO:0070849]; response to exogenous dsRNA [GO:0043330]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; steroid hormone mediated signaling pathway [GO:0043401]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]	azurophil granule lumen [GO:0035578]; caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; synapse [GO:0045202]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; phosphatase binding [GO:0019902]; phosphotyrosine residue binding [GO:0001784]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]	azurophil granule lumen [GO:0035578]; caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; synapse [GO:0045202]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; phosphatase binding [GO:0019902]; phosphotyrosine residue binding [GO:0001784]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; androgen receptor signaling pathway [GO:0030521]; apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; Bergmann glial cell differentiation [GO:0060020]; cardiac neural crest cell development involved in heart development [GO:0061308]; caveolin-mediated endocytosis [GO:0072584]; cell cycle [GO:0007049]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amino acid starvation [GO:0034198]; cellular response to cadmium ion [GO:0071276]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; chemical synaptic transmission [GO:0007268]; chemotaxis [GO:0006935]; cytosine metabolic process [GO:0019858]; DNA damage response [GO:0006974]; ERBB signaling pathway [GO:0038127]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; learning or memory [GO:0007611]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; long-term synaptic potentiation [GO:0060291]; lung morphogenesis [GO:0060425]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of cell differentiation [GO:0045596]; outer ear morphogenesis [GO:0042473]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; progesterone receptor signaling pathway [GO:0050847]; protein phosphorylation [GO:0006468]; regulation of cellular pH [GO:0030641]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of ossification [GO:0030278]; regulation of protein stability [GO:0031647]; regulation of stress-activated MAPK cascade [GO:0032872]; response to epidermal growth factor [GO:0070849]; response to exogenous dsRNA [GO:0043330]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; steroid hormone mediated signaling pathway [GO:0043401]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Nucleus {ECO:0000269|PubMed:32721402}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm {ECO:0000269|PubMed:32721402}. Membrane, caveola {ECO:0000250|UniProtKB:P63086}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P63085}. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}.
P28562	reviewed	DUS1_HUMAN	Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100)	DUSP1 CL100 MKP1 PTPN10 VH1	Homo sapiens (Human)	367	FUNCTION: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250|UniProtKB:P28563}.		cell cycle [GO:0007049]; cellular response to chemokine [GO:1990869]; endoderm formation [GO:0001706]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of p38MAPK cascade [GO:1903753]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; mitogen-activated protein kinase binding [GO:0051019]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; mitogen-activated protein kinase binding [GO:0051019]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]; cell cycle [GO:0007049]; cellular response to chemokine [GO:1990869]; endoderm formation [GO:0001706]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of p38MAPK cascade [GO:1903753]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91790}.
P28566	reviewed	5HT1E_HUMAN	5-hydroxytryptamine receptor 1E (5-HT-1E) (5-HT1E) (S31) (Serotonin receptor 1E)	HTR1E	Homo sapiens (Human)	365	FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled receptor activity [GO:0004930]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}; Multi-pass membrane protein {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}.
P28676	reviewed	GRAN_HUMAN	Grancalcin	GCA GCL	Homo sapiens (Human)	217	FUNCTION: Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.	MISCELLANEOUS: This protein has been shown to bind calcium with high affinity.	membrane fusion [GO:0061025]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; membrane fusion [GO:0061025]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1530588, ECO:0000269|PubMed:1737748}. Cytoplasmic granule membrane {ECO:0000269|PubMed:1737748, ECO:0000305|PubMed:1530588}; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels. {ECO:0000269|PubMed:1737748}.
P28698	reviewed	MZF1_HUMAN	Myeloid zinc finger 1 (MZF-1) (Zinc finger and SCAN domain-containing protein 6) (Zinc finger protein 42)	MZF1 MZF ZNF42 ZSCAN6	Homo sapiens (Human)	734	FUNCTION: Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development. {ECO:0000269|PubMed:15541732, ECO:0000269|PubMed:17851584}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus.
P28702	reviewed	RXRB_HUMAN	Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)	RXRB NR2B2	Homo sapiens (Human)	533	FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE). {ECO:0000269|PubMed:1310259}.		anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; hormone-mediated signaling pathway [GO:0009755]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of bone mineralization [GO:0030501]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; hormone-mediated signaling pathway [GO:0009755]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of bone mineralization [GO:0030501]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1310259, ECO:0000269|PubMed:28167758}. Cytoplasm {ECO:0000269|PubMed:28167758}.
P28715	reviewed	ERCC5_HUMAN	DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (Xeroderma pigmentosum group G-complementing protein)	ERCC5 ERCM2 XPG XPGC	Homo sapiens (Human)	1186	FUNCTION: Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:8206890, PubMed:8090225, PubMed:8078765, PubMed:7651464, PubMed:32821917, PubMed:32522879). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:8090225, PubMed:8078765, PubMed:32821917, PubMed:32522879). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}.	MISCELLANEOUS: [Isoform 3]: Includes a cryptic exon found in intron 6. {ECO:0000305}.	base-excision repair, AP site formation [GO:0006285]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of apoptotic process [GO:0043066]; nucleotide-excision repair [GO:0006289]; regulation of catalytic activity [GO:0050790]; response to UV [GO:0009411]; response to UV-C [GO:0010225]; transcription-coupled nucleotide-excision repair [GO:0006283]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	bubble DNA binding [GO:0000405]; damaged DNA binding [GO:0003684]; DNA endonuclease activity [GO:0004520]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; RNA polymerase II complex binding [GO:0000993]; single-stranded DNA binding [GO:0003697]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; bubble DNA binding [GO:0000405]; damaged DNA binding [GO:0003684]; DNA endonuclease activity [GO:0004520]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; RNA polymerase II complex binding [GO:0000993]; single-stranded DNA binding [GO:0003697]; base-excision repair, AP site formation [GO:0006285]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of apoptotic process [GO:0043066]; nucleotide-excision repair [GO:0006289]; regulation of catalytic activity [GO:0050790]; response to UV [GO:0009411]; response to UV-C [GO:0010225]; transcription-coupled nucleotide-excision repair [GO:0006283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:7651464}. Chromosome {ECO:0000269|PubMed:26833090}. Note=Colocalizes with RAD51 to nuclear foci in S phase (PubMed:26833090). Localizes to DNA double-strand breaks (DBS) during replication stress (PubMed:26833090). Colocalizes with BRCA2 to nuclear foci following DNA replication stress (PubMed:26833090). {ECO:0000269|PubMed:26833090}.
P28749	reviewed	RBL1_HUMAN	Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)	RBL1	Homo sapiens (Human)	1068	FUNCTION: Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}.		cell cycle [GO:0007049]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of cellular senescence [GO:2000773]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of lipid kinase activity [GO:0043550]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	promoter-specific chromatin binding [GO:1990841]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of cellular senescence [GO:2000773]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of lipid kinase activity [GO:0043550]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P28799	reviewed	GRN_HUMAN	Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]	GRN	Homo sapiens (Human)	593	FUNCTION: Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28541286, PubMed:28073925, PubMed:18378771, PubMed:28453791, PubMed:12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771). {ECO:0000250|UniProtKB:P28798, ECO:0000269|PubMed:12526812, ECO:0000269|PubMed:18378771, ECO:0000269|PubMed:28073925, ECO:0000269|PubMed:28453791, ECO:0000269|PubMed:28541286}.; FUNCTION: [Granulin-4]: Promotes proliferation of the epithelial cell line A431 in culture.; FUNCTION: [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. {ECO:0000269|PubMed:12526812}.; FUNCTION: [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. {ECO:0000269|PubMed:28453791}.		astrocyte activation involved in immune response [GO:0002265]; lysosomal lumen acidification [GO:0007042]; lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; microglial cell activation involved in immune response [GO:0002282]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; positive regulation of angiogenesis [GO:0045766]; positive regulation of aspartic-type peptidase activity [GO:1905247]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell migration [GO:0030335]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of inflammatory response to wounding [GO:0106016]; positive regulation of lysosome organization [GO:1905673]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein folding [GO:1903334]; protein stabilization [GO:0050821]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; astrocyte activation involved in immune response [GO:0002265]; lysosomal lumen acidification [GO:0007042]; lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; microglial cell activation involved in immune response [GO:0002282]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; positive regulation of angiogenesis [GO:0045766]; positive regulation of aspartic-type peptidase activity [GO:1905247]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell migration [GO:0030335]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of inflammatory response to wounding [GO:0106016]; positive regulation of lysosome organization [GO:1905673]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein folding [GO:1903334]; protein stabilization [GO:0050821]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21092856, ECO:0000269|PubMed:26370502}. Lysosome {ECO:0000269|PubMed:21092856, ECO:0000269|PubMed:26370502, ECO:0000269|PubMed:28073925, ECO:0000269|PubMed:28541286, ECO:0000269|PubMed:28743268}. Note=Endocytosed by SORT1 and delivred to lysosomes (PubMed:21092856, PubMed:28073925). Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925). Co-localized with GBA1 in the intracellular trafficking compartments until to lysosome (By similarity). {ECO:0000250|UniProtKB:P28798, ECO:0000269|PubMed:21092856, ECO:0000269|PubMed:26370502, ECO:0000269|PubMed:28073925}.
P28827	reviewed	PTPRM_HUMAN	Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)	PTPRM PTPRL1	Homo sapiens (Human)	1452	FUNCTION: Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:17761881, PubMed:10753936). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202). {ECO:0000269|PubMed:10753936, ECO:0000269|PubMed:16456543, ECO:0000269|PubMed:17761881, ECO:0000269|PubMed:21998202}.		cytoplasmic sequestering of protein [GO:0051220]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; response to xenobiotic stimulus [GO:0009410]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; intracellular non-membrane-bounded organelle [GO:0043232]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; intracellular non-membrane-bounded organelle [GO:0043232]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; cytoplasmic sequestering of protein [GO:0051220]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; response to xenobiotic stimulus [GO:0009410]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10753936}; Single-pass type I membrane protein. Note=Localizes in regions of cell-cell contact. {ECO:0000269|PubMed:10753936}.
P28838	reviewed	AMPL_HUMAN	Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase)	LAP3 LAPEP PEPS	Homo sapiens (Human)	519	FUNCTION: Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250|UniProtKB:P00727}.		proteolysis [GO:0006508]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]	aminopeptidase activity [GO:0004177]; carboxypeptidase activity [GO:0004180]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; peptidase activity [GO:0008233]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; aminopeptidase activity [GO:0004177]; carboxypeptidase activity [GO:0004180]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; peptidase activity [GO:0008233]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q68FS4}.
P28845	reviewed	DHI1_HUMAN	11-beta-hydroxysteroid dehydrogenase 1 (11-DH) (11-beta-HSD1) (EC 1.1.1.146) (7-oxosteroid reductase) (EC 1.1.1.201) (Corticosteroid 11-beta-dehydrogenase isozyme 1) (Short chain dehydrogenase/reductase family 26C member 1)	HSD11B1 HSD11 HSD11L SDR26C1	Homo sapiens (Human)	292	FUNCTION: Controls the reversible conversion of biologically active glucocorticoids such as cortisone to cortisol, and 11-dehydrocorticosterone to corticosterone in the presence of NADP(H) (PubMed:10497248, PubMed:12460758, PubMed:14973125, PubMed:15152005, PubMed:15280030, PubMed:17593962, PubMed:21453287, PubMed:27927697, PubMed:30902677). Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes (PubMed:12414862, PubMed:10497248, PubMed:15152005, PubMed:21453287). Plays a role in the secretion of aqueous humor in the eye, maintaining a normotensive, intraocular environment (PubMed:11481269). Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids (PubMed:12414862, PubMed:10497248, PubMed:11481269, PubMed:12460758). It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates (PubMed:15095019, PubMed:15152005, PubMed:17593962, PubMed:21453287). Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others (PubMed:17593962). Catalyzes the stereo-specific conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol metabolite (PubMed:15095019, PubMed:15152005). 7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation (PubMed:15095019). Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism (PubMed:21453287). Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (PubMed:30902677). {ECO:0000269|PubMed:10497248, ECO:0000269|PubMed:12460758, ECO:0000269|PubMed:14973125, ECO:0000269|PubMed:15095019, ECO:0000269|PubMed:15152005, ECO:0000269|PubMed:17593962, ECO:0000269|PubMed:21453287, ECO:0000269|PubMed:27927697, ECO:0000269|PubMed:30902677, ECO:0000303|PubMed:10497248, ECO:0000303|PubMed:11481269, ECO:0000303|PubMed:12414862, ECO:0000303|PubMed:12460758, ECO:0000303|PubMed:15095019, ECO:0000303|PubMed:15152005, ECO:0000303|PubMed:21453287}.		lung development [GO:0030324]; steroid catabolic process [GO:0006706]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	11-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0070524]; 7-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0047022]; cortisol dehydrogenase activity [GO:0102196]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; steroid binding [GO:0005496]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; 11-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0070524]; 7-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0047022]; cortisol dehydrogenase activity [GO:0102196]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; steroid binding [GO:0005496]; lung development [GO:0030324]; steroid catabolic process [GO:0006706]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10497248, ECO:0000269|PubMed:15280030}; Single-pass type II membrane protein {ECO:0000269|PubMed:10497248}.
P28906	reviewed	CD34_HUMAN	Hematopoietic progenitor cell antigen CD34 (CD antigen CD34)	CD34	Homo sapiens (Human)	385	FUNCTION: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.		cell motility [GO:0048870]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endothelial cell proliferation [GO:0001935]; endothelium development [GO:0003158]; extracellular exosome assembly [GO:0071971]; glomerular endothelium development [GO:0072011]; glomerular filtration [GO:0003094]; hematopoietic stem cell proliferation [GO:0071425]; hemopoiesis [GO:0030097]; leukocyte migration [GO:0050900]; mesangial cell-matrix adhesion [GO:0035759]; metanephric glomerular mesangial cell differentiation [GO:0072254]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-2 production [GO:0032703]; paracrine signaling [GO:0038001]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of odontogenesis [GO:0042482]; positive regulation of vasculogenesis [GO:2001214]; signal transduction [GO:0007165]; stem cell proliferation [GO:0072089]; tissue homeostasis [GO:0001894]; transdifferentiation [GO:0060290]; vascular wound healing [GO:0061042]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; glomerular endothelium fenestra [GO:0036053]; intercellular bridge [GO:0045171]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sulfate binding [GO:0043199]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; glomerular endothelium fenestra [GO:0036053]; intercellular bridge [GO:0045171]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sulfate binding [GO:0043199]; cell motility [GO:0048870]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endothelial cell proliferation [GO:0001935]; endothelium development [GO:0003158]; extracellular exosome assembly [GO:0071971]; glomerular endothelium development [GO:0072011]; glomerular filtration [GO:0003094]; hematopoietic stem cell proliferation [GO:0071425]; hemopoiesis [GO:0030097]; leukocyte migration [GO:0050900]; mesangial cell-matrix adhesion [GO:0035759]; metanephric glomerular mesangial cell differentiation [GO:0072254]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-2 production [GO:0032703]; paracrine signaling [GO:0038001]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of odontogenesis [GO:0042482]; positive regulation of vasculogenesis [GO:2001214]; signal transduction [GO:0007165]; stem cell proliferation [GO:0072089]; tissue homeostasis [GO:0001894]; transdifferentiation [GO:0060290]; vascular wound healing [GO:0061042]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P28907	reviewed	CD38_HUMAN	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (T10) (CD antigen CD38)	CD38	Homo sapiens (Human)	300	FUNCTION: Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:8253715, PubMed:7961800). Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+) (PubMed:16690024). Has cADPR hydrolase activity (PubMed:8253715, PubMed:7961800). {ECO:0000269|PubMed:16690024, ECO:0000269|PubMed:7961800, ECO:0000269|PubMed:8253715}.	MISCELLANEOUS: A cell surface antigen recognized in lymophocytes by multiple mAbs. {ECO:0000269|PubMed:2319135}.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	apoptotic signaling pathway [GO:0097190]; artery smooth muscle contraction [GO:0014824]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; female pregnancy [GO:0007565]; long-term synaptic depression [GO:0060292]; NAD metabolic process [GO:0019674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone resorption [GO:0045779]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron projection development [GO:0010977]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell growth [GO:0030307]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion [GO:0032024]; positive regulation of vasoconstriction [GO:0045907]; response to estradiol [GO:0032355]; response to hydroperoxide [GO:0033194]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; phosphorus-oxygen lyase activity [GO:0016849]; transferase activity [GO:0016740]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; phosphorus-oxygen lyase activity [GO:0016849]; transferase activity [GO:0016740]; apoptotic signaling pathway [GO:0097190]; artery smooth muscle contraction [GO:0014824]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; female pregnancy [GO:0007565]; long-term synaptic depression [GO:0060292]; NAD metabolic process [GO:0019674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone resorption [GO:0045779]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron projection development [GO:0010977]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell growth [GO:0030307]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion [GO:0032024]; positive regulation of vasoconstriction [GO:0045907]; response to estradiol [GO:0032355]; response to hydroperoxide [GO:0033194]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:2319135}. Membrane {ECO:0000269|PubMed:8253715}; Single-pass type II membrane protein.
P28908	reviewed	TNR8_HUMAN	Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)	TNFRSF8 CD30 D1S166E	Homo sapiens (Human)	595	FUNCTION: Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898). {ECO:0000269|PubMed:8391931, ECO:0000269|PubMed:8999898}.	MISCELLANEOUS: Most specific Hodgkin disease associated antigen.	cellular response to mechanical stimulus [GO:0071260]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of TRAIL production [GO:0032759]; positive regulation of tumor necrosis factor production [GO:0032760]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; cellular response to mechanical stimulus [GO:0071260]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of TRAIL production [GO:0032759]; positive regulation of tumor necrosis factor production [GO:0032760]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:8391931, ECO:0000305|PubMed:8999898}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:8839832}.
P29016	reviewed	CD1B_HUMAN	T-cell surface glycoprotein CD1b (CD antigen CD1b)	CD1B	Homo sapiens (Human)	333	FUNCTION: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:10981968, ECO:0000269|PubMed:14716313}.	MISCELLANEOUS: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface. Interaction with saposin C is required for the loading of bacterial lipid antigens onto CD1B in the lysosome.	adaptive immune response [GO:0002250]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	cell surface [GO:0009986]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipopeptide binding [GO:0071723]	cell surface [GO:0009986]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipopeptide binding [GO:0071723]; adaptive immune response [GO:0002250]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:10981968, ECO:0000269|PubMed:14716313}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:14716313}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:10981968, ECO:0000269|PubMed:14716313}; Single-pass type I membrane protein {ECO:0000255}. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. {ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:10981968, ECO:0000269|PubMed:14716313}.
P29017	reviewed	CD1C_HUMAN	T-cell surface glycoprotein CD1c (CD antigen CD1c)	CD1C	Homo sapiens (Human)	333	FUNCTION: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:10786796, ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:21167756}.	MISCELLANEOUS: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface.	adaptive immune response [GO:0002250]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; T cell activation involved in immune response [GO:0002286]	endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; glycolipid binding [GO:0051861]; lipopeptide binding [GO:0071723]	endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; glycolipid binding [GO:0051861]; lipopeptide binding [GO:0071723]; adaptive immune response [GO:0002250]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; T cell activation involved in immune response [GO:0002286]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:10899914}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:3097645}; Single-pass type I membrane protein. Lysosome {ECO:0000269|PubMed:10890914}. Note=Subject to intracellular trafficking between the cell membrane and endosomes. {ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:3097645}.
P29033	reviewed	CXB2_HUMAN	Gap junction beta-2 protein (Connexin-26) (Cx26)	GJB2	Homo sapiens (Human)	226	FUNCTION: Structural component of gap junctions (PubMed:17551008, PubMed:19340074, PubMed:21094651, PubMed:26753910, PubMed:16849369, PubMed:19384972). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (PubMed:17551008, PubMed:19340074, PubMed:21094651, PubMed:26753910). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:21094651, PubMed:16849369, PubMed:19384972). {ECO:0000269|PubMed:16849369, ECO:0000269|PubMed:17551008, ECO:0000269|PubMed:19340074, ECO:0000269|PubMed:19384972, ECO:0000269|PubMed:21094651, ECO:0000269|PubMed:26753910}.		cell-cell signaling [GO:0007267]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucagon stimulus [GO:0071377]; cellular response to oxidative stress [GO:0034599]; decidualization [GO:0046697]; epididymis development [GO:1905867]; gap junction assembly [GO:0016264]; gap junction-mediated intercellular transport [GO:1990349]; inner ear development [GO:0048839]; response to estradiol [GO:0032355]; response to human chorionic gonadotropin [GO:0044752]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; sensory perception of sound [GO:0007605]; transmembrane transport [GO:0055085]	astrocyte projection [GO:0097449]; cell body [GO:0044297]; connexin complex [GO:0005922]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; gap junction [GO:0005921]; lateral plasma membrane [GO:0016328]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; gap junction channel activity [GO:0005243]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763]; identical protein binding [GO:0042802]	astrocyte projection [GO:0097449]; cell body [GO:0044297]; connexin complex [GO:0005922]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; gap junction [GO:0005921]; lateral plasma membrane [GO:0016328]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; gap junction channel activity [GO:0005243]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763]; identical protein binding [GO:0042802]; cell-cell signaling [GO:0007267]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucagon stimulus [GO:0071377]; cellular response to oxidative stress [GO:0034599]; decidualization [GO:0046697]; epididymis development [GO:1905867]; gap junction assembly [GO:0016264]; gap junction-mediated intercellular transport [GO:1990349]; inner ear development [GO:0048839]; response to estradiol [GO:0032355]; response to human chorionic gonadotropin [GO:0044752]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; sensory perception of sound [GO:0007605]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16849369, ECO:0000269|PubMed:17551008, ECO:0000269|PubMed:19340074, ECO:0000269|PubMed:19384972, ECO:0000269|PubMed:21094651, ECO:0000269|PubMed:26753910}; Multi-pass membrane protein {ECO:0000269|PubMed:17551008, ECO:0000269|PubMed:19340074, ECO:0000269|PubMed:21094651, ECO:0000269|PubMed:26753910}. Cell junction, gap junction {ECO:0000269|PubMed:16849369, ECO:0000269|PubMed:17551008, ECO:0000269|PubMed:19340074, ECO:0000269|PubMed:19384972, ECO:0000269|PubMed:21094651, ECO:0000269|PubMed:26753910}. Note=Colocalizes with GJB4 at gap junction plaques in the cochlea. {ECO:0000250|UniProtKB:Q00977}.
P29034	reviewed	S10A2_HUMAN	Protein S100-A2 (CAN19) (Protein S-100L) (S100 calcium-binding protein A2)	S100A2 S100L	Homo sapiens (Human)	98	FUNCTION: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth. {ECO:0000269|PubMed:1372446, ECO:0000269|PubMed:22399290}.	MISCELLANEOUS: This protein binds two calcium ions. {ECO:0000250}.	endothelial cell migration [GO:0043542]		calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; transition metal ion binding [GO:0046914]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; transition metal ion binding [GO:0046914]; endothelial cell migration [GO:0043542]	
P29074	reviewed	PTN4_HUMAN	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)	PTPN4	Homo sapiens (Human)	926	FUNCTION: Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441). Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membrane and the cytoskeleton. {ECO:0000250, ECO:0000250|UniProtKB:Q9WU22, ECO:0000269|PubMed:20086240, ECO:0000269|PubMed:25825441, ECO:0000269|PubMed:27246854}.		protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	cytoskeletal protein binding [GO:0008092]; glutamate receptor binding [GO:0035254]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; cytoskeletal protein binding [GO:0008092]; glutamate receptor binding [GO:0035254]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8910369}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8910369}. Cytoplasm {ECO:0000269|PubMed:20086240, ECO:0000269|PubMed:8910369}.
P29083	reviewed	T2EA_HUMAN	General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha)	GTF2E1 TF2E1	Homo sapiens (Human)	439	FUNCTION: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.		transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription open complex formation at RNA polymerase II promoter [GO:0001113]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIE complex [GO:0005673]	metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIE complex [GO:0005673]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription open complex formation at RNA polymerase II promoter [GO:0001113]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1956398, ECO:0000269|PubMed:7651391}.
P29084	reviewed	T2EB_HUMAN	Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2)	GTF2E2 TF2E2	Homo sapiens (Human)	291	FUNCTION: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. {ECO:0000269|PubMed:1956398, ECO:0000269|PubMed:1956404}.		transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIE complex [GO:0005673]	DNA binding [GO:0003677]; RNA binding [GO:0003723]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIE complex [GO:0005673]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7651391}.
P29120	reviewed	NEC1_HUMAN	Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1)	PCSK1 NEC1	Homo sapiens (Human)	753	FUNCTION: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP. {ECO:0000250|UniProtKB:P63239}.		cell-cell signaling [GO:0007267]; insulin processing [GO:0030070]; neurogenesis [GO:0022008]; pancreas development [GO:0031016]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; pituitary gland development [GO:0021983]; positive regulation of protein secretion [GO:0050714]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; response to axon injury [GO:0048678]; response to calcium ion [GO:0051592]; response to chlorate [GO:0010157]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to nutrient levels [GO:0031667]; response to peptide hormone [GO:0043434]; response to xenobiotic stimulus [GO:0009410]	axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; secretory granule lumen [GO:0034774]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]	identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]	axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; secretory granule lumen [GO:0034774]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; cell-cell signaling [GO:0007267]; insulin processing [GO:0030070]; neurogenesis [GO:0022008]; pancreas development [GO:0031016]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; pituitary gland development [GO:0021983]; positive regulation of protein secretion [GO:0050714]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; response to axon injury [GO:0048678]; response to calcium ion [GO:0051592]; response to chlorate [GO:0010157]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to nutrient levels [GO:0031667]; response to peptide hormone [GO:0043434]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.
P29122	reviewed	PCSK6_HUMAN	Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4)	PCSK6 PACE4	Homo sapiens (Human)	969	FUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.	MISCELLANEOUS: [Isoform PACE4B]: Probably enzymatically inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform PACE4C]: Probably enzymatically inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform PACE4CS]: Probably enzymatically inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform PACE4D]: Probably enzymatically inactive. {ECO:0000305}.	determination of left/right symmetry [GO:0007368]; glycoprotein metabolic process [GO:0009100]; nerve growth factor production [GO:0032902]; peptide hormone processing [GO:0016486]; plasma lipoprotein particle remodeling [GO:0034369]; protein processing [GO:0016485]; regulation of BMP signaling pathway [GO:0030510]; secretion by cell [GO:0032940]; zygotic determination of anterior/posterior axis, embryo [GO:0007354]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886]	endopeptidase activity [GO:0004175]; heparin binding [GO:0008201]; nerve growth factor binding [GO:0048406]; serine-type endopeptidase activity [GO:0004252]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; heparin binding [GO:0008201]; nerve growth factor binding [GO:0048406]; serine-type endopeptidase activity [GO:0004252]; determination of left/right symmetry [GO:0007368]; glycoprotein metabolic process [GO:0009100]; nerve growth factor production [GO:0032902]; peptide hormone processing [GO:0016486]; plasma lipoprotein particle remodeling [GO:0034369]; protein processing [GO:0016485]; regulation of BMP signaling pathway [GO:0030510]; secretion by cell [GO:0032940]; zygotic determination of anterior/posterior axis, embryo [GO:0007354]	SUBCELLULAR LOCATION: [Isoform PACE4A-I]: Secreted.; SUBCELLULAR LOCATION: [Isoform PACE4A-II]: Secreted.; SUBCELLULAR LOCATION: [Isoform PACE4C]: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum.; SUBCELLULAR LOCATION: [Isoform PACE4CS]: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum.; SUBCELLULAR LOCATION: [Isoform PACE4E-I]: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus.; SUBCELLULAR LOCATION: [Isoform PACE4E-II]: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus.; SUBCELLULAR LOCATION: [Isoform PACE4B]: Secreted.
P29144	reviewed	TPP2_HUMAN	Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II)	TPP2	Homo sapiens (Human)	1249	FUNCTION: Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q64514, ECO:0000269|PubMed:25525876, ECO:0000269|PubMed:30533531}.	MISCELLANEOUS: The limitation of proteolytic products to tripeptides is achieved by tailoring the size of the substrate-binding cleft: the two negatively charged residues Glu-305 and Glu-331 that are blocking position P4 limit the number of residues that can be accommodated in the binding cleft and thus create a molecular ruler. At the same time, they orient substrates so that the tripeptides are removed exclusively from the N-terminus (By similarity). {ECO:0000250}.	intracellular amino acid homeostasis [GO:0080144]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; tripeptidyl-peptidase activity [GO:0008240]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; tripeptidyl-peptidase activity [GO:0008240]; intracellular amino acid homeostasis [GO:0080144]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19747897}. Nucleus {ECO:0000269|PubMed:19747897}. Note=Translocates to the nucleus in response to gamma-irradiation.
P29218	reviewed	IMPA1_HUMAN	Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1)	IMPA1 IMPA	Homo sapiens (Human)	277	FUNCTION: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. {ECO:0000269|PubMed:17068342, ECO:0000269|PubMed:8718889, ECO:0000269|PubMed:9462881}.		inositol biosynthetic process [GO:0006021]; inositol metabolic process [GO:0006020]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	identical protein binding [GO:0042802]; inositol monophosphate 1-phosphatase activity [GO:0008934]; inositol monophosphate 3-phosphatase activity [GO:0052832]; inositol monophosphate 4-phosphatase activity [GO:0052833]; inositol monophosphate phosphatase activity [GO:0052834]; lithium ion binding [GO:0031403]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; inositol monophosphate 1-phosphatase activity [GO:0008934]; inositol monophosphate 3-phosphatase activity [GO:0052832]; inositol monophosphate 4-phosphatase activity [GO:0052833]; inositol monophosphate phosphatase activity [GO:0052834]; lithium ion binding [GO:0031403]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]; inositol biosynthetic process [GO:0006021]; inositol metabolic process [GO:0006020]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17068342}.
P29274	reviewed	AA2AR_HUMAN	Adenosine receptor A2a	ADORA2A ADORA2	Homo sapiens (Human)	412	FUNCTION: Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250|UniProtKB:P11617}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; astrocyte activation [GO:0048143]; blood circulation [GO:0008015]; blood coagulation [GO:0007596]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; central nervous system development [GO:0007417]; eating behavior [GO:0042755]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; inflammatory response [GO:0006954]; inhibitory postsynaptic potential [GO:0060080]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of vascular permeability [GO:0043116]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein secretion [GO:0050714]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of urine volume [GO:0035810]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of calcium ion transport [GO:0051924]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of norepinephrine secretion [GO:0014061]; response to amphetamine [GO:0001975]; response to caffeine [GO:0031000]; response to inorganic substance [GO:0010035]; response to purine-containing compound [GO:0014074]; response to xenobiotic stimulus [GO:0009410]; sensory perception [GO:0007600]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission, dopaminergic [GO:0001963]; synaptic transmission, glutamatergic [GO:0035249]; vasodilation [GO:0042311]	asymmetric synapse [GO:0032279]; axolemma [GO:0030673]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; intermediate filament [GO:0005882]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]	alpha-actinin binding [GO:0051393]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; G protein-coupled adenosine receptor activity [GO:0001609]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein-containing complex binding [GO:0044877]; type 5 metabotropic glutamate receptor binding [GO:0031802]	asymmetric synapse [GO:0032279]; axolemma [GO:0030673]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; intermediate filament [GO:0005882]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; alpha-actinin binding [GO:0051393]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; G protein-coupled adenosine receptor activity [GO:0001609]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein-containing complex binding [GO:0044877]; type 5 metabotropic glutamate receptor binding [GO:0031802]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; astrocyte activation [GO:0048143]; blood circulation [GO:0008015]; blood coagulation [GO:0007596]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; central nervous system development [GO:0007417]; eating behavior [GO:0042755]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; inflammatory response [GO:0006954]; inhibitory postsynaptic potential [GO:0060080]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of vascular permeability [GO:0043116]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein secretion [GO:0050714]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of urine volume [GO:0035810]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of calcium ion transport [GO:0051924]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of norepinephrine secretion [GO:0014061]; response to amphetamine [GO:0001975]; response to caffeine [GO:0031000]; response to inorganic substance [GO:0010035]; response to purine-containing compound [GO:0014074]; response to xenobiotic stimulus [GO:0009410]; sensory perception [GO:0007600]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission, dopaminergic [GO:0001963]; synaptic transmission, glutamatergic [GO:0035249]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30543}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30543}. Note=Colocalizes with GAS2L2 at neuronal processes. {ECO:0000250|UniProtKB:P30543}.
P29275	reviewed	AA2BR_HUMAN	Adenosine receptor A2b	ADORA2B	Homo sapiens (Human)	332	FUNCTION: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.		activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to extracellular stimulus [GO:0031668]; cGMP-mediated signaling [GO:0019934]; G protein-coupled receptor signaling pathway [GO:0007186]; mast cell degranulation [GO:0043303]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of chemokine production [GO:0032722]; positive regulation of chronic inflammatory response to non-antigenic stimulus [GO:0002882]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of vascular endothelial growth factor production [GO:0010575]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; relaxation of vascular associated smooth muscle [GO:0060087]; vasodilation [GO:0042311]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]	G protein-coupled adenosine receptor activity [GO:0001609]; G protein-coupled receptor activity [GO:0004930]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; G protein-coupled adenosine receptor activity [GO:0001609]; G protein-coupled receptor activity [GO:0004930]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to extracellular stimulus [GO:0031668]; cGMP-mediated signaling [GO:0019934]; G protein-coupled receptor signaling pathway [GO:0007186]; mast cell degranulation [GO:0043303]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of chemokine production [GO:0032722]; positive regulation of chronic inflammatory response to non-antigenic stimulus [GO:0002882]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of vascular endothelial growth factor production [GO:0010575]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; relaxation of vascular associated smooth muscle [GO:0060087]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P29279	reviewed	CCN2_HUMAN	CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8)	CCN2 CTGF HCS24 IGFBP8	Homo sapiens (Human)	349	FUNCTION: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. {ECO:0000269|PubMed:10614647, ECO:0000269|PubMed:12553878}.		angiogenesis [GO:0001525]; cartilage condensation [GO:0001502]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; DNA biosynthetic process [GO:0071897]; epidermis development [GO:0008544]; fibroblast growth factor receptor signaling pathway [GO:0008543]; integrin-mediated signaling pathway [GO:0007229]; lung development [GO:0030324]; negative regulation of gene expression [GO:0010629]; ossification [GO:0001503]; positive regulation of cell differentiation [GO:0045597]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of stress fiber assembly [GO:0051496]; reactive oxygen species metabolic process [GO:0072593]; regulation of chondrocyte differentiation [GO:0032330]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; tissue homeostasis [GO:0001894]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	heparin binding [GO:0008201]; insulin-like growth factor binding [GO:0005520]; integrin binding [GO:0005178]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; heparin binding [GO:0008201]; insulin-like growth factor binding [GO:0005520]; integrin binding [GO:0005178]; angiogenesis [GO:0001525]; cartilage condensation [GO:0001502]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; DNA biosynthetic process [GO:0071897]; epidermis development [GO:0008544]; fibroblast growth factor receptor signaling pathway [GO:0008543]; integrin-mediated signaling pathway [GO:0007229]; lung development [GO:0030324]; negative regulation of gene expression [GO:0010629]; ossification [GO:0001503]; positive regulation of cell differentiation [GO:0045597]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of stress fiber assembly [GO:0051496]; reactive oxygen species metabolic process [GO:0072593]; regulation of chondrocyte differentiation [GO:0032330]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; tissue homeostasis [GO:0001894]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P29268}. Secreted {ECO:0000250|UniProtKB:P29268}.
P29317	reviewed	EPHA2_HUMAN	Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)	EPHA2 ECK	Homo sapiens (Human)	976	FUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}.		activation of GTPase activity [GO:0090630]; axial mesoderm formation [GO:0048320]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cAMP metabolic process [GO:0046058]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell motility [GO:0048870]; defense response to Gram-positive bacterium [GO:0050830]; ephrin receptor signaling pathway [GO:0048013]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinocyte differentiation [GO:0030216]; lens fiber cell morphogenesis [GO:0070309]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of angiogenesis [GO:0016525]; negative regulation of chemokine production [GO:0032682]; negative regulation of lymphangiogenesis [GO:1901491]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; notochord cell development [GO:0060035]; notochord formation [GO:0014028]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; pericyte cell differentiation [GO:1904238]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell migration [GO:0030335]; positive regulation of protein localization to plasma membrane [GO:1903078]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of lamellipodium assembly [GO:0010591]; response to growth factor [GO:0070848]; skeletal system development [GO:0001501]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasculogenesis [GO:0001570]	cell surface [GO:0009986]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; leading edge membrane [GO:0031256]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; tight junction [GO:0070160]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; ephrin receptor activity [GO:0005003]; growth factor binding [GO:0019838]; molecular function activator activity [GO:0140677]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; leading edge membrane [GO:0031256]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; tight junction [GO:0070160]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; ephrin receptor activity [GO:0005003]; growth factor binding [GO:0019838]; molecular function activator activity [GO:0140677]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; virus receptor activity [GO:0001618]; activation of GTPase activity [GO:0090630]; axial mesoderm formation [GO:0048320]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cAMP metabolic process [GO:0046058]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell motility [GO:0048870]; defense response to Gram-positive bacterium [GO:0050830]; ephrin receptor signaling pathway [GO:0048013]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinocyte differentiation [GO:0030216]; lens fiber cell morphogenesis [GO:0070309]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of angiogenesis [GO:0016525]; negative regulation of chemokine production [GO:0032682]; negative regulation of lymphangiogenesis [GO:1901491]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; notochord cell development [GO:0060035]; notochord formation [GO:0014028]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; pericyte cell differentiation [GO:1904238]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell migration [GO:0030335]; positive regulation of protein localization to plasma membrane [GO:1903078]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of lamellipodium assembly [GO:0010591]; response to growth factor [GO:0070848]; skeletal system development [GO:0001501]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18794797, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20223987, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:34067457}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:19573808}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:19573808}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000269|PubMed:10655584}. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311). Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797). {ECO:0000269|PubMed:18794797, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:26158630}.
P29320	reviewed	EPHA3_HUMAN	Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)	EPHA3 ETK ETK1 HEK TYRO4	Homo sapiens (Human)	983	FUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}.		axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to retinoic acid [GO:0071300]; ephrin receptor signaling pathway [GO:0048013]; fasciculation of motor neuron axon [GO:0097156]; fasciculation of sensory neuron axon [GO:0097155]; negative regulation of endocytosis [GO:0045806]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of microtubule cytoskeleton organization [GO:0070507]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular region [GO:0005576]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003]; GPI-linked ephrin receptor activity [GO:0005004]; transmembrane-ephrin receptor activity [GO:0005005]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular region [GO:0005576]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003]; GPI-linked ephrin receptor activity [GO:0005004]; transmembrane-ephrin receptor activity [GO:0005005]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to retinoic acid [GO:0071300]; ephrin receptor signaling pathway [GO:0048013]; fasciculation of motor neuron axon [GO:0097156]; fasciculation of sensory neuron axon [GO:0097155]; negative regulation of endocytosis [GO:0045806]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of microtubule cytoskeleton organization [GO:0070507]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:11870224}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:21135139}.
P29322	reviewed	EPHA8_HUMAN	Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK)	EPHA8 EEK HEK3 KIAA1459	Homo sapiens (Human)	1005	FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; ephrin receptor signaling pathway [GO:0048013]; neuron projection development [GO:0031175]; neuron remodeling [GO:0016322]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; substrate-dependent cell migration [GO:0006929]	dendrite [GO:0030425]; early endosome membrane [GO:0031901]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; transmembrane-ephrin receptor activity [GO:0005005]	dendrite [GO:0030425]; early endosome membrane [GO:0031901]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; transmembrane-ephrin receptor activity [GO:0005005]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; ephrin receptor signaling pathway [GO:0048013]; neuron projection development [GO:0031175]; neuron remodeling [GO:0016322]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; substrate-dependent cell migration [GO:0006929]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O09127}; Single-pass type I membrane protein {ECO:0000255}. Cell projection {ECO:0000250|UniProtKB:O09127}. Early endosome membrane {ECO:0000250|UniProtKB:O09127}. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes. {ECO:0000250|UniProtKB:O09127}.
P29323	reviewed	EPHB2_HUMAN	Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]	EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5	Homo sapiens (Human)	1055	FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}.		angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; B cell activation [GO:0042113]; camera-type eye morphogenesis [GO:0048593]; cellular response to amyloid-beta [GO:1904646]; cellular response to lipopolysaccharide [GO:0071222]; central nervous system projection neuron axonogenesis [GO:0021952]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; ephrin receptor signaling pathway [GO:0048013]; hindbrain tangential cell migration [GO:0021934]; inner ear morphogenesis [GO:0042472]; learning [GO:0007612]; learning or memory [GO:0007611]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of NMDA glutamate receptor activity [GO:1904782]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of Ras protein signal transduction [GO:0046580]; nervous system development [GO:0007399]; neuron projection retraction [GO:0106028]; optic nerve morphogenesis [GO:0021631]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphorylation [GO:0016310]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell migration [GO:0030335]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of tumor necrosis factor production [GO:0032760]; postsynaptic membrane assembly [GO:0097104]; regulation of autophagosome assembly [GO:2000785]; regulation of behavioral fear response [GO:2000822]; regulation of blood coagulation [GO:0030193]; regulation of body fluid levels [GO:0050878]; regulation of filopodium assembly [GO:0051489]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of T-helper 17 type immune response [GO:2000316]; retinal ganglion cell axon guidance [GO:0031290]; roof of mouth development [GO:0060021]; tight junction assembly [GO:0120192]; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission [GO:0099557]; urogenital system development [GO:0001655]; vesicle-mediated intercellular transport [GO:0110077]	axon [GO:0030424]; cell surface [GO:0009986]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; transmembrane-ephrin receptor activity [GO:0005005]	axon [GO:0030424]; cell surface [GO:0009986]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; transmembrane-ephrin receptor activity [GO:0005005]; angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; B cell activation [GO:0042113]; camera-type eye morphogenesis [GO:0048593]; cellular response to amyloid-beta [GO:1904646]; cellular response to lipopolysaccharide [GO:0071222]; central nervous system projection neuron axonogenesis [GO:0021952]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; ephrin receptor signaling pathway [GO:0048013]; hindbrain tangential cell migration [GO:0021934]; inner ear morphogenesis [GO:0042472]; learning [GO:0007612]; learning or memory [GO:0007611]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of NMDA glutamate receptor activity [GO:1904782]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of Ras protein signal transduction [GO:0046580]; nervous system development [GO:0007399]; neuron projection retraction [GO:0106028]; optic nerve morphogenesis [GO:0021631]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphorylation [GO:0016310]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell migration [GO:0030335]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of tumor necrosis factor production [GO:0032760]; postsynaptic membrane assembly [GO:0097104]; regulation of autophagosome assembly [GO:2000785]; regulation of behavioral fear response [GO:2000822]; regulation of blood coagulation [GO:0030193]; regulation of body fluid levels [GO:0050878]; regulation of filopodium assembly [GO:0051489]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of T-helper 17 type immune response [GO:2000316]; retinal ganglion cell axon guidance [GO:0031290]; roof of mouth development [GO:0060021]; tight junction assembly [GO:0120192]; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission [GO:0099557]; urogenital system development [GO:0001655]; vesicle-mediated intercellular transport [GO:0110077]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
P29350	reviewed	PTN6_HUMAN	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)	PTPN6 HCP PTP1C	Homo sapiens (Human)	595	FUNCTION: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. {ECO:0000269|PubMed:11266449}.		B cell receptor signaling pathway [GO:0050853]; cell differentiation [GO:0030154]; cytokine-mediated signaling pathway [GO:0019221]; epididymis development [GO:1905867]; G protein-coupled receptor signaling pathway [GO:0007186]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; megakaryocyte development [GO:0035855]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002924]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein dephosphorylation [GO:0006470]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]	alpha-beta T cell receptor complex [GO:0042105]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	cell adhesion molecule binding [GO:0050839]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphorylation-dependent protein binding [GO:0140031]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	alpha-beta T cell receptor complex [GO:0042105]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; cell adhesion molecule binding [GO:0050839]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphorylation-dependent protein binding [GO:0140031]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; B cell receptor signaling pathway [GO:0050853]; cell differentiation [GO:0030154]; cytokine-mediated signaling pathway [GO:0019221]; epididymis development [GO:1905867]; G protein-coupled receptor signaling pathway [GO:0007186]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; megakaryocyte development [GO:0035855]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002924]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein dephosphorylation [GO:0006470]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. {ECO:0000250}.
P29353	reviewed	SHC1_HUMAN	SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)	SHC1 SHC SHCA	Homo sapiens (Human)	583	FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}.	MISCELLANEOUS: [Isoform p66Shc]: Regulated by epigenetic modifications of its promoter region.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Produced by alternative splicing. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cellular response to growth factor stimulus [GO:0071363]; defense response to bacterium [GO:0042742]; epidermal growth factor receptor signaling pathway [GO:0007173]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; regulation of superoxide metabolic process [GO:0090322]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; mitochondrial matrix [GO:0005759]; plasma membrane [GO:0005886]; Shc-EGFR complex [GO:0070435]	ephrin receptor binding [GO:0046875]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor binding [GO:0005154]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; neurotrophin TRKA receptor binding [GO:0005168]; phospholipid binding [GO:0005543]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; mitochondrial matrix [GO:0005759]; plasma membrane [GO:0005886]; Shc-EGFR complex [GO:0070435]; ephrin receptor binding [GO:0046875]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor binding [GO:0005154]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; neurotrophin TRKA receptor binding [GO:0005168]; phospholipid binding [GO:0005543]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cellular response to growth factor stimulus [GO:0071363]; defense response to bacterium [GO:0042742]; epidermal growth factor receptor signaling pathway [GO:0007173]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; regulation of superoxide metabolic process [GO:0090322]	SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion {ECO:0000269|PubMed:35687021}.; SUBCELLULAR LOCATION: [Isoform p46Shc]: Mitochondrion matrix {ECO:0000269|PubMed:14573619}. Note=Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.; SUBCELLULAR LOCATION: [Isoform p66Shc]: Mitochondrion {ECO:0000250}. Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation. {ECO:0000250}.
P29371	reviewed	NK3R_HUMAN	Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3)	TACR3 NK3R TAC3R	Homo sapiens (Human)	465	FUNCTION: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.		positive regulation of blood pressure [GO:0045777]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of heart rate [GO:0010460]; positive regulation of uterine smooth muscle contraction [GO:0070474]; regulation of dopamine metabolic process [GO:0042053]; regulation of feeding behavior [GO:0060259]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; tachykinin receptor signaling pathway [GO:0007217]	dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]	tachykinin receptor activity [GO:0004995]	dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]; tachykinin receptor activity [GO:0004995]; positive regulation of blood pressure [GO:0045777]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of heart rate [GO:0010460]; positive regulation of uterine smooth muscle contraction [GO:0070474]; regulation of dopamine metabolic process [GO:0042053]; regulation of feeding behavior [GO:0060259]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; tachykinin receptor signaling pathway [GO:0007217]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P29372	reviewed	3MG_HUMAN	DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase)	MPG AAG ANPG MID1	Homo sapiens (Human)	298	FUNCTION: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.		base-excision repair [GO:0006284]; depurination [GO:0045007]; DNA dealkylation involved in DNA repair [GO:0006307]	cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; nucleoplasm [GO:0005654]	alkylbase DNA N-glycosylase activity [GO:0003905]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-3-methyladenine glycosylase activity [GO:0008725]; DNA-3-methylguanine glycosylase activity [GO:0052822]; DNA-7-methyladenine glycosylase activity [GO:0052821]; DNA-7-methylguanine glycosylase activity [GO:0043916]	cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; nucleoplasm [GO:0005654]; alkylbase DNA N-glycosylase activity [GO:0003905]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-3-methyladenine glycosylase activity [GO:0008725]; DNA-3-methylguanine glycosylase activity [GO:0052822]; DNA-7-methyladenine glycosylase activity [GO:0052821]; DNA-7-methylguanine glycosylase activity [GO:0043916]; base-excision repair [GO:0006284]; depurination [GO:0045007]; DNA dealkylation involved in DNA repair [GO:0006307]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23290262}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:23290262}. Nucleus {ECO:0000269|PubMed:23290262}.
P29373	reviewed	RABP2_HUMAN	Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II)	CRABP2	Homo sapiens (Human)	138	FUNCTION: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.		embryonic forelimb morphogenesis [GO:0035115]; epidermis development [GO:0008544]; fatty acid transport [GO:0015908]; positive regulation of collateral sprouting [GO:0048672]; regulation of DNA-templated transcription [GO:0006355]; retinoic acid metabolic process [GO:0042573]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin binding [GO:0030332]; fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoic acid binding [GO:0001972]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin binding [GO:0030332]; fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoic acid binding [GO:0001972]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]; embryonic forelimb morphogenesis [GO:0035115]; epidermis development [GO:0008544]; fatty acid transport [GO:0015908]; positive regulation of collateral sprouting [GO:0048672]; regulation of DNA-templated transcription [GO:0006355]; retinoic acid metabolic process [GO:0042573]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
P29374	reviewed	ARI4A_HUMAN	AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1)	ARID4A RBBP1 RBP1	Homo sapiens (Human)	1257	FUNCTION: DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}.		DNA methylation [GO:0006306]; erythrocyte development [GO:0048821]; establishment of Sertoli cell barrier [GO:0097368]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Sin3 complex [GO:0016580]; transcription repressor complex [GO:0017053]	DNA binding [GO:0003677]; transcription cis-regulatory region binding [GO:0000976]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Sin3 complex [GO:0016580]; transcription repressor complex [GO:0017053]; DNA binding [GO:0003677]; transcription cis-regulatory region binding [GO:0000976]; DNA methylation [GO:0006306]; erythrocyte development [GO:0048821]; establishment of Sertoli cell barrier [GO:0097368]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:8414517, ECO:0000269|PubMed:8455946}.
P29375	reviewed	KDM5A_HUMAN	Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A)	KDM5A JARID1A RBBP2 RBP2	Homo sapiens (Human)	1690	FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}.		chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; facultative heterochromatin formation [GO:0140718]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of DNA-templated transcription [GO:0006355]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; methylated histone binding [GO:0035064]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; methylated histone binding [GO:0035064]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; facultative heterochromatin formation [GO:0140718]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:7935440}. Nucleus {ECO:0000250|UniProtKB:Q3UXZ9}. Note=Occupies promoters of genes involved in RNA metabolism and mitochondrial function. {ECO:0000250|UniProtKB:Q3UXZ9}.
P29376	reviewed	LTK_HUMAN	Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)	LTK TYK1	Homo sapiens (Human)	864	FUNCTION: Receptor with a tyrosine-protein kinase activity (PubMed:10445845, PubMed:20548102, PubMed:30061385). Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:20548102). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity). The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival (PubMed:9223670, PubMed:18849880). Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (PubMed:20548102). {ECO:0000250|UniProtKB:Q9UM73, ECO:0000269|PubMed:10445845, ECO:0000269|PubMed:18849880, ECO:0000269|PubMed:20548102, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:9223670}.		cell population proliferation [GO:0008283]; cellular response to retinoic acid [GO:0071300]; negative regulation of apoptotic process [GO:0043066]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein phosphorylation [GO:0006468]; regulation of cell population proliferation [GO:0042127]; regulation of neuron differentiation [GO:0045664]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; cell population proliferation [GO:0008283]; cellular response to retinoic acid [GO:0071300]; negative regulation of apoptotic process [GO:0043066]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein phosphorylation [GO:0006468]; regulation of cell population proliferation [GO:0042127]; regulation of neuron differentiation [GO:0045664]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:34646012}; Single-pass type I membrane protein {ECO:0000255}.
P29400	reviewed	CO4A5_HUMAN	Collagen alpha-5(IV) chain	COL4A5	Homo sapiens (Human)	1685	FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.	MISCELLANEOUS: [Isoform 2]: Contains 2 extra G-X-X repeats into the triple-helix domain. {ECO:0000305}.	collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; extracellular matrix organization [GO:0030198]; neuromuscular junction development [GO:0007528]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; extracellular matrix organization [GO:0030198]; neuromuscular junction development [GO:0007528]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
P29401	reviewed	TKT_HUMAN	Transketolase (TK) (EC 2.2.1.1)	TKT	Homo sapiens (Human)	623	FUNCTION: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}.		glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; regulation of growth [GO:0040008]; xylulose 5-phosphate biosynthetic process [GO:1901159]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; peroxisome [GO:0005777]; vesicle [GO:0031982]	calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; peroxisome [GO:0005777]; vesicle [GO:0031982]; calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; regulation of growth [GO:0040008]; xylulose 5-phosphate biosynthetic process [GO:1901159]	
P29459	reviewed	IL12A_HUMAN	Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (NK cell stimulatory factor chain 1) (NKSF1)	IL12A NKSF1	Homo sapiens (Human)	219	FUNCTION: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine (PubMed:8943050, PubMed:8605935). IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity (PubMed:1673147, PubMed:1674604, PubMed:8605935). Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits (PubMed:8943050). Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2 (PubMed:7528775). In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (PubMed:7638186). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers (PubMed:22306691). Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (PubMed:22306691). {ECO:0000250|UniProtKB:P43431, ECO:0000269|PubMed:1673147, ECO:0000269|PubMed:1674604, ECO:0000269|PubMed:2204066, ECO:0000269|PubMed:22306691, ECO:0000269|PubMed:7528775, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:8605935, ECO:0000269|PubMed:8943050}.		cell migration [GO:0016477]; cellular response to virus [GO:0098586]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; immune response [GO:0006955]; interleukin-12-mediated signaling pathway [GO:0035722]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of protein secretion [GO:0050709]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of mononuclear cell proliferation [GO:0032946]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to lipopolysaccharide [GO:0032496]; response to UV-B [GO:0010224]; response to virus [GO:0009615]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-12 complex [GO:0043514]; late endosome lumen [GO:0031906]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-12 beta subunit binding [GO:0042163]; interleukin-12 receptor binding [GO:0005143]; interleukin-27 binding [GO:0045513]; protein heterodimerization activity [GO:0046982]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-12 complex [GO:0043514]; late endosome lumen [GO:0031906]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-12 beta subunit binding [GO:0042163]; interleukin-12 receptor binding [GO:0005143]; interleukin-27 binding [GO:0045513]; protein heterodimerization activity [GO:0046982]; cell migration [GO:0016477]; cellular response to virus [GO:0098586]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; immune response [GO:0006955]; interleukin-12-mediated signaling pathway [GO:0035722]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of protein secretion [GO:0050709]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of mononuclear cell proliferation [GO:0032946]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to lipopolysaccharide [GO:0032496]; response to UV-B [GO:0010224]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1674604, ECO:0000269|PubMed:9342359}.
P29460	reviewed	IL12B_HUMAN	Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (NK cell stimulatory factor chain 2) (NKSF2)	IL12B NKSF2	Homo sapiens (Human)	328	FUNCTION: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. {ECO:0000269|PubMed:11114383}.; FUNCTION: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269|PubMed:11114383}.		cell migration [GO:0016477]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; interleukin-12-mediated signaling pathway [GO:0035722]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of protein secretion [GO:0050709]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of cell adhesion [GO:0045785]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of mononuclear cell proliferation [GO:0032946]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of cytokine production [GO:0001817]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]; response to UV-B [GO:0010224]; sexual reproduction [GO:0019953]; T cell proliferation [GO:0042098]; T-helper 1 type immune response [GO:0042088]; T-helper cell differentiation [GO:0042093]	cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-12 complex [GO:0043514]; interleukin-23 complex [GO:0070743]; late endosome lumen [GO:0031906]; receptor complex [GO:0043235]	cytokine activity [GO:0005125]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; interleukin-12 alpha subunit binding [GO:0042164]; interleukin-12 receptor binding [GO:0005143]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]	cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-12 complex [GO:0043514]; interleukin-23 complex [GO:0070743]; late endosome lumen [GO:0031906]; receptor complex [GO:0043235]; cytokine activity [GO:0005125]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; interleukin-12 alpha subunit binding [GO:0042164]; interleukin-12 receptor binding [GO:0005143]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]; cell migration [GO:0016477]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; interleukin-12-mediated signaling pathway [GO:0035722]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of protein secretion [GO:0050709]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of cell adhesion [GO:0045785]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of mononuclear cell proliferation [GO:0032946]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of cytokine production [GO:0001817]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]; response to UV-B [GO:0010224]; sexual reproduction [GO:0019953]; T cell proliferation [GO:0042098]; T-helper 1 type immune response [GO:0042088]; T-helper cell differentiation [GO:0042093]	SUBCELLULAR LOCATION: Secreted.
P29466	reviewed	CASP1_HUMAN	Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]	CASP1 IL1BC IL1BCE	Homo sapiens (Human)	404	FUNCTION: Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides (PubMed:15326478, PubMed:1574116, PubMed:7876192, PubMed:15498465, PubMed:26375003, PubMed:32051255). Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes (PubMed:1574116, PubMed:7876192, PubMed:15498465, PubMed:15326478, PubMed:32051255). Cleaves a tetrapeptide after an Asp residue at position P1 (PubMed:1574116, PubMed:7876192, PubMed:15498465). Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD (PubMed:26375003). In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32051255, PubMed:32109412, PubMed:32553275). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (PubMed:22464733). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (PubMed:20197547). {ECO:0000269|PubMed:15326478, ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:1574116, ECO:0000269|PubMed:20197547, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:32051255, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:32553275, ECO:0000269|PubMed:7876192}.; FUNCTION: [Isoform Delta]: Apoptosis inactive. {ECO:0000269|PubMed:7876192}.; FUNCTION: [Isoform Epsilon]: Apoptosis inactive. {ECO:0000269|PubMed:7876192}.		AIM2 inflammasome complex assembly [GO:0140970]; apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic substance [GO:0071310]; cellular response to type II interferon [GO:0071346]; cytokine precursor processing [GO:0140447]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; icosanoid biosynthetic process [GO:0046456]; osmosensory signaling pathway [GO:0007231]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein autoprocessing [GO:0016540]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165]; signaling receptor ligand precursor processing [GO:0140448]	AIM2 inflammasome complex [GO:0097169]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; IPAF inflammasome complex [GO:0072557]; microtubule [GO:0005874]; NLRP1 inflammasome complex [GO:0072558]; NLRP3 inflammasome complex [GO:0072559]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protease inhibitor complex [GO:0097179]; protein-containing complex [GO:0032991]	CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]	AIM2 inflammasome complex [GO:0097169]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; IPAF inflammasome complex [GO:0072557]; microtubule [GO:0005874]; NLRP1 inflammasome complex [GO:0072558]; NLRP3 inflammasome complex [GO:0072559]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protease inhibitor complex [GO:0097179]; protein-containing complex [GO:0032991]; CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; AIM2 inflammasome complex assembly [GO:0140970]; apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic substance [GO:0071310]; cellular response to type II interferon [GO:0071346]; cytokine precursor processing [GO:0140447]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; icosanoid biosynthetic process [GO:0046456]; osmosensory signaling pathway [GO:0007231]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein autoprocessing [GO:0016540]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165]; signaling receptor ligand precursor processing [GO:0140448]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20197547}. Cell membrane {ECO:0000269|PubMed:20197547}.
P29474	reviewed	NOS3_HUMAN	Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS)	NOS3	Homo sapiens (Human)	1203	FUNCTION: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. {ECO:0000269|PubMed:1378832}.; FUNCTION: [Isoform eNOS13C]: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.	MISCELLANEOUS: [Isoform eNOS13C]: Lacks eNOS activity. {ECO:0000305}.	angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; arginine catabolic process [GO:0006527]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; calcium ion transport [GO:0006816]; cell redox homeostasis [GO:0045454]; endocardial cushion morphogenesis [GO:0003203]; endothelial cell migration [GO:0043542]; establishment of localization in cell [GO:0051649]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; lung development [GO:0030324]; mitochondrion organization [GO:0007005]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of muscle hyperplasia [GO:0014740]; negative regulation of platelet activation [GO:0010544]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of smooth muscle cell proliferation [GO:0048662]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; ovulation from ovarian follicle [GO:0001542]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of gene expression [GO:0010628]; positive regulation of guanylate cyclase activity [GO:0031284]; positive regulation of Notch signaling pathway [GO:0045747]; potassium ion transport [GO:0006813]; pulmonary valve morphogenesis [GO:0003184]; regulation of blood pressure [GO:0008217]; regulation of nervous system process [GO:0031644]; regulation of sodium ion transport [GO:0002028]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of the force of heart contraction by chemical signal [GO:0003057]; removal of superoxide radicals [GO:0019430]; response to fluid shear stress [GO:0034405]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to lipopolysaccharide [GO:0032496]; smooth muscle hyperplasia [GO:0014806]; vasodilation [GO:0042311]; ventricular septum morphogenesis [GO:0060412]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	actin monomer binding [GO:0003785]; arginine binding [GO:0034618]; cadmium ion binding [GO:0046870]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; scaffold protein binding [GO:0097110]; tetrahydrobiopterin binding [GO:0034617]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; actin monomer binding [GO:0003785]; arginine binding [GO:0034618]; cadmium ion binding [GO:0046870]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; scaffold protein binding [GO:0097110]; tetrahydrobiopterin binding [GO:0034617]; angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; arginine catabolic process [GO:0006527]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; calcium ion transport [GO:0006816]; cell redox homeostasis [GO:0045454]; endocardial cushion morphogenesis [GO:0003203]; endothelial cell migration [GO:0043542]; establishment of localization in cell [GO:0051649]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; lung development [GO:0030324]; mitochondrion organization [GO:0007005]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of muscle hyperplasia [GO:0014740]; negative regulation of platelet activation [GO:0010544]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of smooth muscle cell proliferation [GO:0048662]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; ovulation from ovarian follicle [GO:0001542]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of gene expression [GO:0010628]; positive regulation of guanylate cyclase activity [GO:0031284]; positive regulation of Notch signaling pathway [GO:0045747]; potassium ion transport [GO:0006813]; pulmonary valve morphogenesis [GO:0003184]; regulation of blood pressure [GO:0008217]; regulation of nervous system process [GO:0031644]; regulation of sodium ion transport [GO:0002028]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of the force of heart contraction by chemical signal [GO:0003057]; removal of superoxide radicals [GO:0019430]; response to fluid shear stress [GO:0034405]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to lipopolysaccharide [GO:0032496]; smooth muscle hyperplasia [GO:0014806]; vasodilation [GO:0042311]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
P29475	reviewed	NOS1_HUMAN	Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Nitric oxide synthase, brain) (bNOS) (Peptidyl-cysteine S-nitrosylase NOS1)	NOS1	Homo sapiens (Human)	1434	FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. {ECO:0000269|PubMed:35772285}.		arginine catabolic process [GO:0006527]; cell redox homeostasis [GO:0045454]; cellular response to growth factor stimulus [GO:0071363]; multicellular organismal response to stress [GO:0033555]; muscle contraction [GO:0006936]; myoblast fusion [GO:0007520]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of hydrolase activity [GO:0051346]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of serotonin uptake [GO:0051612]; neurotransmitter biosynthetic process [GO:0042136]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; peptidyl-cysteine S-nitrosylation [GO:0018119]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of sodium ion transmembrane transport [GO:1902307]; positive regulation of the force of heart contraction [GO:0098735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle contraction [GO:0055117]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of sodium ion transport [GO:0002028]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; retrograde trans-synaptic signaling by nitric oxide [GO:0098924]; striated muscle contraction [GO:0006941]; vasodilation [GO:0042311]; xenobiotic catabolic process [GO:0042178]	cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; synapse [GO:0045202]	arginine binding [GO:0034618]; cadmium ion binding [GO:0046870]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; scaffold protein binding [GO:0097110]; sodium channel regulator activity [GO:0017080]; tetrahydrobiopterin binding [GO:0034617]; transmembrane transporter binding [GO:0044325]	cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; synapse [GO:0045202]; arginine binding [GO:0034618]; cadmium ion binding [GO:0046870]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; scaffold protein binding [GO:0097110]; sodium channel regulator activity [GO:0017080]; tetrahydrobiopterin binding [GO:0034617]; transmembrane transporter binding [GO:0044325]; arginine catabolic process [GO:0006527]; cell redox homeostasis [GO:0045454]; cellular response to growth factor stimulus [GO:0071363]; multicellular organismal response to stress [GO:0033555]; muscle contraction [GO:0006936]; myoblast fusion [GO:0007520]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of hydrolase activity [GO:0051346]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of serotonin uptake [GO:0051612]; neurotransmitter biosynthetic process [GO:0042136]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; peptidyl-cysteine S-nitrosylation [GO:0018119]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of sodium ion transmembrane transport [GO:1902307]; positive regulation of the force of heart contraction [GO:0098735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle contraction [GO:0055117]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of sodium ion transport [GO:0002028]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; retrograde trans-synaptic signaling by nitric oxide [GO:0098924]; striated muscle contraction [GO:0006941]; vasodilation [GO:0042311]; xenobiotic catabolic process [GO:0042178]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q9Z0J4}; Peripheral membrane protein {ECO:0000255}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P29476}. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex (By similarity). In neurons, enriched in dendritic spines (By similarity). {ECO:0000250|UniProtKB:P29476, ECO:0000250|UniProtKB:Q9Z0J4}.
P29508	reviewed	SPB3_HUMAN	Serpin B3 (Protein T4-A) (Squamous cell carcinoma antigen 1) (SCCA-1)	SERPINB3 SCCA SCCA1	Homo sapiens (Human)	390	FUNCTION: May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). {ECO:0000269|PubMed:19166818}.		autocrine signaling [GO:0035425]; negative regulation of catalytic activity [GO:0043086]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]; paracrine signaling [GO:0038001]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of epithelial to mesenchymal transition [GO:0010718]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; virus receptor activity [GO:0001618]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; virus receptor activity [GO:0001618]; autocrine signaling [GO:0035425]; negative regulation of catalytic activity [GO:0043086]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]; paracrine signaling [GO:0038001]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of epithelial to mesenchymal transition [GO:0010718]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10956412, ECO:0000269|PubMed:14970861}. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
P29536	reviewed	LMOD1_HUMAN	Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen)	LMOD1	Homo sapiens (Human)	600	FUNCTION: Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:28292896}.		actin filament organization [GO:0007015]; actin nucleation [GO:0045010]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of actin filament polymerization [GO:0030838]	actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]	actin binding [GO:0003779]; tropomyosin binding [GO:0005523]	actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]; actin binding [GO:0003779]; tropomyosin binding [GO:0005523]; actin filament organization [GO:0007015]; actin nucleation [GO:0045010]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of actin filament polymerization [GO:0030838]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:26370058}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0A0G2K0D3}. Note=Colocalizes with actin filaments in sarcomeres. {ECO:0000250|UniProtKB:A0A0G2K0D3}.
P29558	reviewed	RBMS1_HUMAN	RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) (Suppressor of CDC2 with RNA-binding motif 2)	RBMS1 C2orf12 MSSP MSSP1 SCR2	Homo sapiens (Human)	406	FUNCTION: Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	DNA replication [GO:0006260]; RNA processing [GO:0006396]	cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	double-stranded DNA binding [GO:0003690]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]	cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; double-stranded DNA binding [GO:0003690]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; DNA replication [GO:0006260]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus.
P29590	reviewed	PML_HUMAN	Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)	PML MYL PP8675 RNF71 TRIM19	Homo sapiens (Human)	882	FUNCTION: Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}.	MISCELLANEOUS: [Isoform PML-8]: Non-canonical splice sites. Might alternatively represent a polymorphic variation. {ECO:0000305}.	apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; oncogene-induced cell senescence [GO:0090402]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of telomere maintenance [GO:0032206]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; protein-containing complex assembly [GO:0065003]; protein-containing complex localization [GO:0031503]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein signal transduction [GO:0060395]; suppression of viral release by host [GO:0044790]; transforming growth factor beta receptor signaling pathway [GO:0007179]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	cobalt ion binding [GO:0050897]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SMAD binding [GO:0046332]; SUMO binding [GO:0032183]; SUMO transferase activity [GO:0019789]; sumo-dependent protein binding [GO:0140037]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase activity [GO:0061659]; zinc ion binding [GO:0008270]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; cobalt ion binding [GO:0050897]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SMAD binding [GO:0046332]; SUMO binding [GO:0032183]; SUMO transferase activity [GO:0019789]; sumo-dependent protein binding [GO:0140037]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase activity [GO:0061659]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; oncogene-induced cell senescence [GO:0090402]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of telomere maintenance [GO:0032206]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; protein-containing complex assembly [GO:0065003]; protein-containing complex localization [GO:0031503]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein signal transduction [GO:0060395]; suppression of viral release by host [GO:0044790]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleoplasm. Cytoplasm {ECO:0000269|PubMed:27211601}. Nucleus, PML body {ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:27211601, ECO:0000269|PubMed:36373674}. Nucleus, nucleolus. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform PML-1 can shuttle between the nucleus and cytoplasm. Isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6 are nuclear isoforms whereas isoform PML-7 and isoform PML-14 lacking the nuclear localization signal are cytoplasmic isoforms. Detected in the nucleolus after DNA damage. Acetylation at Lys-487 is essential for its nuclear localization. Within the nucleus, most of PML is expressed in the diffuse nuclear fraction of the nucleoplasm and only a small fraction is found in the matrix-associated nuclear bodies (PML-NBs). The transfer of PML from the nucleoplasm to PML-NBs depends on its phosphorylation and sumoylation. The B1 box and the RING finger are also required for the localization in PML-NBs. Also found in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Sequestered in the cytoplasm by interaction with rabies virus phosphoprotein.
P29597	reviewed	TYK2_HUMAN	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)	TYK2	Homo sapiens (Human)	1187	FUNCTION: Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:8232552, PubMed:7813427, PubMed:7657660, PubMed:10995743, PubMed:10542297). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:7813427, PubMed:10542297, PubMed:7526154, PubMed:25762719). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:7657660, PubMed:10542297, PubMed:25762719). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862). {ECO:0000269|PubMed:10542297, ECO:0000269|PubMed:10995743, ECO:0000269|PubMed:25762719, ECO:0000269|PubMed:29162862, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:8232552}.		cell differentiation [GO:0030154]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; immune response [GO:0006955]; interleukin-12-mediated signaling pathway [GO:0035722]; intracellular signal transduction [GO:0035556]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of type II interferon production [GO:0032729]; protein phosphorylation [GO:0006468]; receptor signaling pathway via JAK-STAT [GO:0007259]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of plasma membrane [GO:0019897]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; type 1 angiotensin receptor binding [GO:0031702]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of plasma membrane [GO:0019897]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; type 1 angiotensin receptor binding [GO:0031702]; cell differentiation [GO:0030154]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; immune response [GO:0006955]; interleukin-12-mediated signaling pathway [GO:0035722]; intracellular signal transduction [GO:0035556]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of type II interferon production [GO:0032729]; protein phosphorylation [GO:0006468]; receptor signaling pathway via JAK-STAT [GO:0007259]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196]	
P29622	reviewed	KAIN_HUMAN	Kallistatin (Kallikrein inhibitor) (Peptidase inhibitor 4) (PI-4) (Serpin A4)	SERPINA4 KST PI4	Homo sapiens (Human)	427	FUNCTION: Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. {ECO:0000269|PubMed:8227002}.	MISCELLANEOUS: Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.		extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted.
P29692	reviewed	EF1D_HUMAN	Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4)	EEF1D EF1D	Homo sapiens (Human)	281	FUNCTION: [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).		cellular response to heat [GO:0034605]; cellular response to ionizing radiation [GO:0071479]; cytoplasmic translational elongation [GO:0002182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; translational elongation [GO:0006414]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; guanyl-nucleotide exchange factor activity [GO:0005085]; heat shock protein binding [GO:0031072]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; translation elongation factor activity [GO:0003746]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; guanyl-nucleotide exchange factor activity [GO:0005085]; heat shock protein binding [GO:0031072]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; translation elongation factor activity [GO:0003746]; translation factor activity, RNA binding [GO:0008135]; cellular response to heat [GO:0034605]; cellular response to ionizing radiation [GO:0071479]; cytoplasmic translational elongation [GO:0002182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; translational elongation [GO:0006414]	SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:21597468}.
P29728	reviewed	OAS2_HUMAN	2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS)	OAS2	Homo sapiens (Human)	719	FUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:9880569, PubMed:11682059). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity). {ECO:0000250|UniProtKB:E9Q9A9, ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:11682059, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880569, ECO:0000303|PubMed:21142819}.		defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of viral genome replication [GO:0045071]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of lactation [GO:1903487]; response to virus [GO:0009615]; RNA catabolic process [GO:0006401]; type I interferon-mediated signaling pathway [GO:0060337]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; 2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of viral genome replication [GO:0045071]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of lactation [GO:1903487]; response to virus [GO:0009615]; RNA catabolic process [GO:0006401]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19923450}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19923450}.
P29803	reviewed	ODPAT_HUMAN	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II)	PDHA2 PDHAL	Homo sapiens (Human)	388	FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:16436377}.		acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; pyruvate metabolic process [GO:0006090]; tricarboxylic acid cycle [GO:0006099]	mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]	pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]; pyruvate dehydrogenase (NAD+) activity [GO:0034604]	mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]; pyruvate dehydrogenase (NAD+) activity [GO:0034604]; acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; pyruvate metabolic process [GO:0006090]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P29965	reviewed	CD40L_HUMAN	CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]	CD40LG CD40L TNFSF5 TRAP	Homo sapiens (Human)	261	FUNCTION: Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). {ECO:0000250|UniProtKB:P27548, ECO:0000269|PubMed:1280226, ECO:0000269|PubMed:15067037, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:8617933}.; FUNCTION: [CD40 ligand, soluble form]: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling. {ECO:0000269|PubMed:31331973}.		B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; CD40 signaling pathway [GO:0023035]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; isotype switching [GO:0045190]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of apoptotic process [GO:0043066]; platelet activation [GO:0030168]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell proliferation [GO:0042102]; regulation of immunoglobulin production [GO:0002637]; T cell costimulation [GO:0031295]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]	CD40 receptor binding [GO:0005174]; cytokine activity [GO:0005125]; integrin binding [GO:0005178]; protein serine/threonine kinase activator activity [GO:0043539]; tumor necrosis factor receptor binding [GO:0005164]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; CD40 receptor binding [GO:0005174]; cytokine activity [GO:0005125]; integrin binding [GO:0005178]; protein serine/threonine kinase activator activity [GO:0043539]; tumor necrosis factor receptor binding [GO:0005164]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; CD40 signaling pathway [GO:0023035]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; isotype switching [GO:0045190]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of apoptotic process [GO:0043066]; platelet activation [GO:0030168]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell proliferation [GO:0042102]; regulation of immunoglobulin production [GO:0002637]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8626375}; Single-pass type II membrane protein {ECO:0000303|PubMed:8626375}. Cell surface {ECO:0000269|PubMed:15067037, ECO:0000269|PubMed:7678552}.; SUBCELLULAR LOCATION: [CD40 ligand, soluble form]: Secreted {ECO:0000269|PubMed:8626375}. Note=Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. {ECO:0000269|PubMed:15193700}.
P29966	reviewed	MARCS_HUMAN	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)	MARCKS MACS PRKCSL	Homo sapiens (Human)	332	FUNCTION: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.		actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; central nervous system development [GO:0007417]; mitochondrion organization [GO:0007005]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; response to endoplasmic reticulum stress [GO:0034976]	actin cytoskeleton [GO:0015629]; actin filament bundle [GO:0032432]; cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; germinal vesicle [GO:0042585]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; protein kinase C binding [GO:0005080]	actin cytoskeleton [GO:0015629]; actin filament bundle [GO:0032432]; cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; germinal vesicle [GO:0042585]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; protein kinase C binding [GO:0005080]; actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; central nervous system development [GO:0007417]; mitochondrion organization [GO:0007005]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
P29972	reviewed	AQP1_HUMAN	Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Urine water channel) (Water channel protein for red blood cells and kidney proximal tubule)	AQP1 CHIP28	Homo sapiens (Human)	269	FUNCTION: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:1373524). Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). {ECO:0000269|PubMed:1373524, ECO:0000269|PubMed:35835865}.	MISCELLANEOUS: Pharmacologically inhibited by submillimolar concentrations of mercury. {ECO:0000305|PubMed:7677994}.	ammonium transmembrane transport [GO:0072488]; camera-type eye morphogenesis [GO:0048593]; carbon dioxide transmembrane transport [GO:0035378]; carbon dioxide transport [GO:0015670]; cell volume homeostasis [GO:0006884]; cellular homeostasis [GO:0019725]; cellular hyperosmotic response [GO:0071474]; cellular response to cAMP [GO:0071320]; cellular response to copper ion [GO:0071280]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to inorganic substance [GO:0071241]; cellular response to mechanical stimulus [GO:0071260]; cellular response to mercury ion [GO:0071288]; cellular response to nitric oxide [GO:0071732]; cellular response to retinoic acid [GO:0071300]; cellular response to salt stress [GO:0071472]; cellular response to UV [GO:0034644]; cerebrospinal fluid secretion [GO:0033326]; cGMP-mediated signaling [GO:0019934]; corticotropin secretion [GO:0051458]; defense response to Gram-negative bacterium [GO:0050829]; establishment of localization in cell [GO:0051649]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; fibroblast migration [GO:0010761]; glomerular filtration [GO:0003094]; glycerol transmembrane transport [GO:0015793]; hyperosmotic response [GO:0006972]; intracellular water homeostasis [GO:0009992]; lateral ventricle development [GO:0021670]; lipid digestion [GO:0044241]; metanephric descending thin limb development [GO:0072220]; metanephric glomerulus vasculature development [GO:0072239]; metanephric proximal convoluted tubule segment 2 development [GO:0072232]; metanephric proximal straight tubule development [GO:0072230]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; nitric oxide transport [GO:0030185]; odontogenesis [GO:0042476]; pancreatic juice secretion [GO:0030157]; positive regulation of angiogenesis [GO:0045766]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of saliva secretion [GO:0046878]; potassium ion transport [GO:0006813]; renal water absorption [GO:0070295]; renal water homeostasis [GO:0003091]; renal water transport [GO:0003097]; secretory granule organization [GO:0033363]; sensory perception of pain [GO:0019233]; transepithelial water transport [GO:0035377]; water transport [GO:0006833]; wound healing [GO:0042060]	ankyrin-1 complex [GO:0170014]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	ammonium transmembrane transporter activity [GO:0008519]; carbon dioxide transmembrane transporter activity [GO:0035379]; ephrin receptor binding [GO:0046875]; glycerol transmembrane transporter activity [GO:0015168]; identical protein binding [GO:0042802]; intracellular cGMP-activated cation channel activity [GO:0005223]; nitric oxide transmembrane transporter activity [GO:0030184]; potassium channel activity [GO:0005267]; potassium ion transmembrane transporter activity [GO:0015079]; transmembrane transporter activity [GO:0022857]; water channel activity [GO:0015250]; water transmembrane transporter activity [GO:0005372]	ankyrin-1 complex [GO:0170014]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; ammonium transmembrane transporter activity [GO:0008519]; carbon dioxide transmembrane transporter activity [GO:0035379]; ephrin receptor binding [GO:0046875]; glycerol transmembrane transporter activity [GO:0015168]; identical protein binding [GO:0042802]; intracellular cGMP-activated cation channel activity [GO:0005223]; nitric oxide transmembrane transporter activity [GO:0030184]; potassium channel activity [GO:0005267]; potassium ion transmembrane transporter activity [GO:0015079]; transmembrane transporter activity [GO:0022857]; water channel activity [GO:0015250]; water transmembrane transporter activity [GO:0005372]; ammonium transmembrane transport [GO:0072488]; camera-type eye morphogenesis [GO:0048593]; carbon dioxide transmembrane transport [GO:0035378]; carbon dioxide transport [GO:0015670]; cell volume homeostasis [GO:0006884]; cellular homeostasis [GO:0019725]; cellular hyperosmotic response [GO:0071474]; cellular response to cAMP [GO:0071320]; cellular response to copper ion [GO:0071280]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to inorganic substance [GO:0071241]; cellular response to mechanical stimulus [GO:0071260]; cellular response to mercury ion [GO:0071288]; cellular response to nitric oxide [GO:0071732]; cellular response to retinoic acid [GO:0071300]; cellular response to salt stress [GO:0071472]; cellular response to UV [GO:0034644]; cerebrospinal fluid secretion [GO:0033326]; cGMP-mediated signaling [GO:0019934]; corticotropin secretion [GO:0051458]; defense response to Gram-negative bacterium [GO:0050829]; establishment of localization in cell [GO:0051649]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; fibroblast migration [GO:0010761]; glomerular filtration [GO:0003094]; glycerol transmembrane transport [GO:0015793]; hyperosmotic response [GO:0006972]; intracellular water homeostasis [GO:0009992]; lateral ventricle development [GO:0021670]; lipid digestion [GO:0044241]; metanephric descending thin limb development [GO:0072220]; metanephric glomerulus vasculature development [GO:0072239]; metanephric proximal convoluted tubule segment 2 development [GO:0072232]; metanephric proximal straight tubule development [GO:0072230]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; nitric oxide transport [GO:0030185]; odontogenesis [GO:0042476]; pancreatic juice secretion [GO:0030157]; positive regulation of angiogenesis [GO:0045766]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of saliva secretion [GO:0046878]; potassium ion transport [GO:0006813]; renal water absorption [GO:0070295]; renal water homeostasis [GO:0003091]; renal water transport [GO:0003097]; secretory granule organization [GO:0033363]; sensory perception of pain [GO:0019233]; transepithelial water transport [GO:0035377]; water transport [GO:0006833]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23219802}; Multi-pass membrane protein {ECO:0000269|PubMed:23219802}.
P29973	reviewed	CNGA1_HUMAN	cGMP-gated cation channel alpha-1 (Cyclic nucleotide-gated cation channel 1) (Cyclic nucleotide-gated channel alpha-1) (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated channel subunit alpha)	CNGA1 CNCG CNCG1	Homo sapiens (Human)	686	FUNCTION: Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. {ECO:0000250|UniProtKB:Q00194}.		monoatomic cation transmembrane transport [GO:0098655]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]	cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877]	intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877]; monoatomic cation transmembrane transport [GO:0098655]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q00194}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q00194}.
P29992	reviewed	GNA11_HUMAN	Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha)	GNA11 GA11	Homo sapiens (Human)	359	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:31073061). Acts as an activator of phospholipase C (PubMed:31073061). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNAQ, required for heart development (By similarity). {ECO:0000250|UniProtKB:P21278, ECO:0000269|PubMed:27852822, ECO:0000269|PubMed:31073061}.		action potential [GO:0001508]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to pH [GO:0071467]; cranial skeletal system development [GO:1904888]; developmental pigmentation [GO:0048066]; endothelin receptor signaling pathway [GO:0086100]; entrainment of circadian clock [GO:0009649]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; heart development [GO:0007507]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; phototransduction, visible light [GO:0007603]; positive regulation of insulin secretion [GO:0032024]; regulation of blood pressure [GO:0008217]; regulation of melanocyte differentiation [GO:0045634]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; synapse [GO:0045202]	enzyme regulator activity [GO:0030234]; G protein activity [GO:0003925]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; synapse [GO:0045202]; enzyme regulator activity [GO:0030234]; G protein activity [GO:0003925]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; action potential [GO:0001508]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to pH [GO:0071467]; cranial skeletal system development [GO:1904888]; developmental pigmentation [GO:0048066]; endothelin receptor signaling pathway [GO:0086100]; entrainment of circadian clock [GO:0009649]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; heart development [GO:0007507]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; phototransduction, visible light [GO:0007603]; positive regulation of insulin secretion [GO:0032024]; regulation of blood pressure [GO:0008217]; regulation of melanocyte differentiation [GO:0045634]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:18703424}; Lipid-anchor {ECO:0000305|PubMed:18703424}. Cytoplasm {ECO:0000269|PubMed:18703424}. Note=In testicular cells, expressed exclusively in the cytoplasm. {ECO:0000269|PubMed:18703424}.
P30038	reviewed	AL4A1_HUMAN	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)	ALDH4A1 ALDH4 P5CDH	Homo sapiens (Human)	563	FUNCTION: Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. {ECO:0000269|PubMed:22516612}.		4-hydroxyproline catabolic process [GO:0019470]; proline catabolic process [GO:0006562]; proline catabolic process to glutamate [GO:0010133]; proline metabolic process [GO:0006560]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	1-pyrroline-5-carboxylate dehydrogenase activity [GO:0003842]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 1-pyrroline-5-carboxylate dehydrogenase activity [GO:0003842]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802]; 4-hydroxyproline catabolic process [GO:0019470]; proline catabolic process [GO:0006562]; proline catabolic process to glutamate [GO:0010133]; proline metabolic process [GO:0006560]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P30039	reviewed	PBLD_HUMAN	Phenazine biosynthesis-like domain-containing protein (EC 5.1.-.-) (MAWD-binding protein) (MAWDBP) (Unknown protein 32 from 2D-page of liver tissue)	PBLD MAWBP	Homo sapiens (Human)	288			biosynthetic process [GO:0009058]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	identical protein binding [GO:0042802]; isomerase activity [GO:0016853]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; biosynthetic process [GO:0009058]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	
P30040	reviewed	ERP29_HUMAN	Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) (ERp28) (Endoplasmic reticulum resident protein 31) (ERp31)	ERP29 C12orf8 ERP28	Homo sapiens (Human)	261	FUNCTION: Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.		intracellular protein transport [GO:0006886]; negative regulation of gene expression [GO:0010629]; negative regulation of protein secretion [GO:0050709]; positive regulation of gene expression [GO:0010628]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein phosphorylation [GO:0001934]; protein folding [GO:0006457]; protein secretion [GO:0009306]; protein unfolding [GO:0043335]; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902235]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]; membrane [GO:0016020]; smooth endoplasmic reticulum [GO:0005790]; transport vesicle [GO:0030133]	protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]; membrane [GO:0016020]; smooth endoplasmic reticulum [GO:0005790]; transport vesicle [GO:0030133]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; intracellular protein transport [GO:0006886]; negative regulation of gene expression [GO:0010629]; negative regulation of protein secretion [GO:0050709]; positive regulation of gene expression [GO:0010628]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein phosphorylation [GO:0001934]; protein folding [GO:0006457]; protein secretion [GO:0009306]; protein unfolding [GO:0043335]; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902235]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
P30041	reviewed	PRDX6_HUMAN	Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12)	PRDX6 AOP2 KIAA0106	Homo sapiens (Human)	224	FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:9497358, PubMed:10893423). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10893423). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10893423, PubMed:26830860). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed:10893423). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed:10893423). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed:26830860). {ECO:0000269|PubMed:10893423, ECO:0000269|PubMed:26830860, ECO:0000269|PubMed:9497358}.	MISCELLANEOUS: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. C(P) is reactivated by glutathionylation mediated by glutathione S-transferase Pi, followed by spontaneous reduction of the enzyme with glutathione. {ECO:0000250|UniProtKB:O35244}.	cell redox homeostasis [GO:0045454]; cellular oxidant detoxification [GO:0098869]; glycerophospholipid catabolic process [GO:0046475]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; response to oxidative stress [GO:0006979]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; cadherin binding [GO:0045296]; calcium-independent phospholipase A2 activity [GO:0047499]; glutathione peroxidase activity [GO:0004602]; identical protein binding [GO:0042802]; peroxiredoxin activity [GO:0051920]; phospholipase A2 activity [GO:0004623]; ubiquitin protein ligase binding [GO:0031625]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; cadherin binding [GO:0045296]; calcium-independent phospholipase A2 activity [GO:0047499]; glutathione peroxidase activity [GO:0004602]; identical protein binding [GO:0042802]; peroxiredoxin activity [GO:0051920]; phospholipase A2 activity [GO:0004623]; ubiquitin protein ligase binding [GO:0031625]; cell redox homeostasis [GO:0045454]; cellular oxidant detoxification [GO:0098869]; glycerophospholipid catabolic process [GO:0046475]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16186110, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:9497358}. Lysosome {ECO:0000250|UniProtKB:O35244}. Note=Also found in lung secretory organelles (lamellar bodies). {ECO:0000250|UniProtKB:O35244}.
P30043	reviewed	BLVRB_HUMAN	Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR)	BLVRB FLR	Homo sapiens (Human)	206	FUNCTION: Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. {ECO:0000269|PubMed:10620517}.		heme catabolic process [GO:0042167]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	biliberdin reductase NAD+ activity [GO:0106276]; biliverdin reductase (NAD(P)+) activity [GO:0004074]; biliverdin reductase (NADP+) activity [GO:0106277]; riboflavin reductase (NADPH) activity [GO:0042602]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; biliberdin reductase NAD+ activity [GO:0106276]; biliverdin reductase (NAD(P)+) activity [GO:0004074]; biliverdin reductase (NADP+) activity [GO:0106277]; riboflavin reductase (NADPH) activity [GO:0042602]; heme catabolic process [GO:0042167]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7929092}.
P30044	reviewed	PRDX5_HUMAN	Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5)	PRDX5 ACR1 SBBI10	Homo sapiens (Human)	214	FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}.	MISCELLANEOUS: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys Prx, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin. {ECO:0000305|PubMed:10751410, ECO:0000305|PubMed:18489898}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing. {ECO:0000305}.	cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; hydrogen peroxide catabolic process [GO:0042744]; inflammatory response [GO:0006954]; NADPH oxidation [GO:0070995]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of transcription by RNA polymerase III [GO:0016480]; positive regulation of collagen biosynthetic process [GO:0032967]; reactive nitrogen species metabolic process [GO:2001057]; regulation of apoptosis involved in tissue homeostasis [GO:0060785]; response to oxidative stress [GO:0006979]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	antioxidant activity [GO:0016209]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; peroxidase activity [GO:0004601]; peroxynitrite reductase activity [GO:0072541]; RNA polymerase III transcription regulatory region sequence-specific DNA binding [GO:0001016]; signaling receptor binding [GO:0005102]; thioredoxin peroxidase activity [GO:0008379]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; antioxidant activity [GO:0016209]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; peroxidase activity [GO:0004601]; peroxynitrite reductase activity [GO:0072541]; RNA polymerase III transcription regulatory region sequence-specific DNA binding [GO:0001016]; signaling receptor binding [GO:0005102]; thioredoxin peroxidase activity [GO:0008379]; cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; hydrogen peroxide catabolic process [GO:0042744]; inflammatory response [GO:0006954]; NADPH oxidation [GO:0070995]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of transcription by RNA polymerase III [GO:0016480]; positive regulation of collagen biosynthetic process [GO:0032967]; reactive nitrogen species metabolic process [GO:2001057]; regulation of apoptosis involved in tissue homeostasis [GO:0060785]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion {ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}.; SUBCELLULAR LOCATION: [Isoform Cytoplasmic+peroxisomal]: Cytoplasm {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10751410}. Peroxisome matrix {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410}. Note=Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5. {ECO:0000269|PubMed:10514471}.
P30046	reviewed	DOPD_HUMAN	D-dopachrome decarboxylase (EC 4.1.1.84) (D-dopachrome tautomerase) (Phenylpyruvate tautomerase II)	DDT	Homo sapiens (Human)	118	FUNCTION: Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). {ECO:0000269|PubMed:8267597, ECO:0000269|PubMed:9480844}.		melanin biosynthetic process [GO:0042438]; negative regulation of macrophage chemotaxis [GO:0010760]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of tumor necrosis factor production [GO:0032760]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	cytokine receptor binding [GO:0005126]; D-dopachrome decarboxylase activity [GO:0033981]; dopachrome isomerase activity [GO:0004167]; phenylpyruvate tautomerase activity [GO:0050178]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; cytokine receptor binding [GO:0005126]; D-dopachrome decarboxylase activity [GO:0033981]; dopachrome isomerase activity [GO:0004167]; phenylpyruvate tautomerase activity [GO:0050178]; melanin biosynthetic process [GO:0042438]; negative regulation of macrophage chemotaxis [GO:0010760]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of tumor necrosis factor production [GO:0032760]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:8267597}.
P30047	reviewed	GFRP_HUMAN	GTP cyclohydrolase 1 feedback regulatory protein (GFRP) (GTP cyclohydrolase I feedback regulatory protein) (p35)	GCHFR GFRP	Homo sapiens (Human)	84	FUNCTION: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. {ECO:0000269|PubMed:16778797}.		negative regulation of biosynthetic process [GO:0009890]; neurotransmitter metabolic process [GO:0042133]; nitric oxide biosynthetic process [GO:0006809]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; melanosome [GO:0042470]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GTP cyclohydrolase binding [GO:0044549]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; melanosome [GO:0042470]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; GTP cyclohydrolase binding [GO:0044549]; negative regulation of biosynthetic process [GO:0009890]; neurotransmitter metabolic process [GO:0042133]; nitric oxide biosynthetic process [GO:0006809]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16778797}. Nucleus membrane {ECO:0000269|PubMed:16778797}. Cytoplasm, cytosol {ECO:0000269|PubMed:16778797}.
P30048	reviewed	PRDX3_HUMAN	Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)	PRDX3 AOP1	Homo sapiens (Human)	256	FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404, PubMed:29438714, PubMed:33889951). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477). Required for the maintenance of physical strength (By similarity). {ECO:0000250|UniProtKB:P20108, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:17707404, ECO:0000269|PubMed:29438714, ECO:0000269|PubMed:33889951, ECO:0000269|PubMed:7733872}.	MISCELLANEOUS: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin. {ECO:0000305|PubMed:17707404}.	cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; hydrogen peroxide catabolic process [GO:0042744]; maternal placenta development [GO:0001893]; mitochondrion organization [GO:0007005]; myeloid cell differentiation [GO:0030099]; negative regulation of apoptotic process [GO:0043066]; negative regulation of kinase activity [GO:0033673]; peptidyl-cysteine oxidation [GO:0018171]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of mitochondrial membrane potential [GO:0051881]; response to hydrogen peroxide [GO:0042542]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	alkyl hydroperoxide reductase activity [GO:0008785]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; thioredoxin peroxidase activity [GO:0008379]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; alkyl hydroperoxide reductase activity [GO:0008785]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; thioredoxin peroxidase activity [GO:0008379]; cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; hydrogen peroxide catabolic process [GO:0042744]; maternal placenta development [GO:0001893]; mitochondrion organization [GO:0007005]; myeloid cell differentiation [GO:0030099]; negative regulation of apoptotic process [GO:0043066]; negative regulation of kinase activity [GO:0033673]; peptidyl-cysteine oxidation [GO:0018171]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of mitochondrial membrane potential [GO:0051881]; response to hydrogen peroxide [GO:0042542]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:33889951}. Cytoplasm {ECO:0000305|PubMed:12492477}. Early endosome {ECO:0000269|PubMed:15750338}. Note=Localizes to early endosomes in a RPS6KC1-dependent manner. {ECO:0000269|PubMed:15750338}.
P30049	reviewed	ATPD_HUMAN	ATP synthase subunit delta, mitochondrial (ATP synthase F1 subunit delta) (F-ATPase delta subunit)	ATP5F1D ATP5D	Homo sapiens (Human)	168	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:29478781). F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (PubMed:1531933). {ECO:0000269|PubMed:29478781, ECO:0000303|PubMed:1531933}.		aerobic respiration [GO:0009060]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to copper ion [GO:0046688]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) [GO:0000275]; mitochondrion [GO:0005739]	proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) [GO:0000275]; mitochondrion [GO:0005739]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; aerobic respiration [GO:0009060]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to copper ion [GO:0046688]	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane.
P30050	reviewed	RL12_HUMAN	Large ribosomal subunit protein uL11 (60S ribosomal protein L12)	RPL12	Homo sapiens (Human)	165	FUNCTION: Binds directly to 26S ribosomal RNA. {ECO:0000250}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; postsynaptic density [GO:0014069]	large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; postsynaptic density [GO:0014069]; large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	
P30084	reviewed	ECHM_HUMAN	Enoyl-CoA hydratase, mitochondrial (mECH) (mECH1) (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (ECHS1) (Short-chain enoyl-CoA hydratase) (SCEH)	ECHS1	Homo sapiens (Human)	290	FUNCTION: Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding (3S)-3hydroxyacyl-CoA species through addition of a water molecule to the double bond (PubMed:25125611, PubMed:26251176). Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (PubMed:26251176). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA) (PubMed:26251176). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (PubMed:26251176). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation (PubMed:25125611, PubMed:26251176). At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity). {ECO:0000250|UniProtKB:P14604, ECO:0000269|PubMed:25125611, ECO:0000269|PubMed:26251176}.		branched-chain amino acid catabolic process [GO:0009083]; fatty acid beta-oxidation [GO:0006635]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	3-hydroxypropionyl-CoA dehydratase activity [GO:0043956]; crotonyl-CoA hydratase activity [GO:0120092]; delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; enoyl-CoA hydratase activity [GO:0004300]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 3-hydroxypropionyl-CoA dehydratase activity [GO:0043956]; crotonyl-CoA hydratase activity [GO:0120092]; delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; enoyl-CoA hydratase activity [GO:0004300]; branched-chain amino acid catabolic process [GO:0009083]; fatty acid beta-oxidation [GO:0006635]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P30085	reviewed	KCY_HUMAN	UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK)	CMPK1 CMK CMPK UCK UMK UMPK	Homo sapiens (Human)	196	FUNCTION: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132, ECO:0000269|PubMed:23416111}.	MISCELLANEOUS: [Isoform 3]: May be produced from an in-frame upstream initiation codon. However, experimental evidence indicates that use of the downstream initiation codon is more likely (isoform 1 sequence). {ECO:0000305}.	'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; CDP biosynthetic process [GO:0046705]; nucleobase-containing small molecule interconversion [GO:0015949]; phosphorylation [GO:0016310]; pyrimidine ribonucleotide biosynthetic process [GO:0009220]; UDP biosynthetic process [GO:0006225]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; cytidylate kinase activity [GO:0004127]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside monophosphate kinase activity [GO:0050145]; UMP kinase activity [GO:0033862]; uridine kinase activity [GO:0004849]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; cytidylate kinase activity [GO:0004127]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside monophosphate kinase activity [GO:0050145]; UMP kinase activity [GO:0033862]; uridine kinase activity [GO:0004849]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; CDP biosynthetic process [GO:0046705]; nucleobase-containing small molecule interconversion [GO:0015949]; phosphorylation [GO:0016310]; pyrimidine ribonucleotide biosynthetic process [GO:0009220]; UDP biosynthetic process [GO:0006225]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132}. Note=Predominantly cytoplasmic, less than 15% nuclear. {ECO:0000269|PubMed:11912132}.
P30086	reviewed	PEBP1_HUMAN	Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]	PEBP1 PBP PEBP	Homo sapiens (Human)	187	FUNCTION: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.		negative regulation of MAPK cascade [GO:0043409]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; phosphatidylethanolamine binding [GO:0008429]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; serine-type endopeptidase inhibitor activity [GO:0004867]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; phosphatidylethanolamine binding [GO:0008429]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of MAPK cascade [GO:0043409]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
P30101	reviewed	PDIA3_HUMAN	Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)	PDIA3 ERP57 ERP60 GRP58	Homo sapiens (Human)	505	FUNCTION: Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:7487104, PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}.		cellular response to interleukin-7 [GO:0098761]; extrinsic apoptotic signaling pathway [GO:0097191]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; platelet aggregation [GO:0070527]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; response to endoplasmic reticulum stress [GO:0034976]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; MHC class I peptide loading complex [GO:0042824]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; recycling endosome membrane [GO:0055038]; Tapasin-ERp57 complex [GO:0061779]	cysteine-type endopeptidase activity [GO:0004197]; disulfide oxidoreductase activity [GO:0015036]; identical protein binding [GO:0042802]; phospholipase C activity [GO:0004629]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; MHC class I peptide loading complex [GO:0042824]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; recycling endosome membrane [GO:0055038]; Tapasin-ERp57 complex [GO:0061779]; cysteine-type endopeptidase activity [GO:0004197]; disulfide oxidoreductase activity [GO:0015036]; identical protein binding [GO:0042802]; phospholipase C activity [GO:0004629]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723]; cellular response to interleukin-7 [GO:0098761]; extrinsic apoptotic signaling pathway [GO:0097191]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; platelet aggregation [GO:0070527]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:23826168}. Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:P11598}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12643545}.
P30153	reviewed	2AAA_HUMAN	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)	PPP2R1A	Homo sapiens (Human)	589	FUNCTION: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). {ECO:0000250|UniProtKB:Q76MZ3, ECO:0000269|PubMed:15525651, ECO:0000269|PubMed:16580887}.		apoptotic process [GO:0006915]; ceramide metabolic process [GO:0006672]; chromosome segregation [GO:0007059]; female meiotic nuclear division [GO:0007143]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; meiotic spindle elongation [GO:0051232]; mitotic sister chromatid separation [GO:0051306]; negative regulation of cell growth [GO:0030308]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein dephosphorylation [GO:0006470]; protein-containing complex assembly [GO:0065003]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of growth [GO:0040008]; regulation of meiotic cell cycle process involved in oocyte maturation [GO:1903538]; regulation of Wnt signaling pathway [GO:0030111]; response to organic substance [GO:0010033]; RNA splicing [GO:0008380]; second-messenger-mediated signaling [GO:0019932]; T cell homeostasis [GO:0043029]	chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	protein antigen binding [GO:1990405]; protein heterodimerization activity [GO:0046982]; protein phosphatase regulator activity [GO:0019888]; protein serine/threonine phosphatase activity [GO:0004722]	chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]; protein antigen binding [GO:1990405]; protein heterodimerization activity [GO:0046982]; protein phosphatase regulator activity [GO:0019888]; protein serine/threonine phosphatase activity [GO:0004722]; apoptotic process [GO:0006915]; ceramide metabolic process [GO:0006672]; chromosome segregation [GO:0007059]; female meiotic nuclear division [GO:0007143]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; meiotic spindle elongation [GO:0051232]; mitotic sister chromatid separation [GO:0051306]; negative regulation of cell growth [GO:0030308]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein dephosphorylation [GO:0006470]; protein-containing complex assembly [GO:0065003]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of growth [GO:0040008]; regulation of meiotic cell cycle process involved in oocyte maturation [GO:1903538]; regulation of Wnt signaling pathway [GO:0030111]; response to organic substance [GO:0010033]; RNA splicing [GO:0008380]; second-messenger-mediated signaling [GO:0019932]; T cell homeostasis [GO:0043029]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q32PI5}. Nucleus {ECO:0000269|PubMed:30611118}. Chromosome, centromere {ECO:0000269|PubMed:16580887}. Lateral cell membrane {ECO:0000269|PubMed:15525651}. Cell projection, dendrite {ECO:0000269|PubMed:15525651}. Note=Centromeric localization requires the presence of BUB1. {ECO:0000269|PubMed:16580887}.
P30154	reviewed	2AAB_HUMAN	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta)	PPP2R1B	Homo sapiens (Human)	601	FUNCTION: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.		apoptotic process involved in morphogenesis [GO:0060561]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase regulator activity [GO:0019888]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; protein phosphatase type 2A complex [GO:0000159]; protein phosphatase regulator activity [GO:0019888]; apoptotic process involved in morphogenesis [GO:0060561]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]	
P30203	reviewed	CD6_HUMAN	T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6]	CD6	Homo sapiens (Human)	668	FUNCTION: Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777). {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:17601777, ECO:0000269|PubMed:24584089, ECO:0000269|PubMed:24945728}.	MISCELLANEOUS: [Isoform 6]: Lacks the third SRCR domain and doesn't bind ALCAM/CD166. Doesn't localize to the immunological synapse. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Lacks the third SRCR domain and doesn't bind ALCAM/CD166. Doesn't localize to the immunological synapse. Constitutes the only expressed species in a small percentage of T-cells. {ECO:0000269|PubMed:17371992}.	acute inflammatory response to antigenic stimulus [GO:0002438]; adaptive immune response [GO:0002250]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immunological synapse formation [GO:0001771]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell proliferation [GO:0042102]; response to lipopolysaccharide [GO:0032496]	cell surface [GO:0009986]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; protein kinase binding [GO:0019901]	cell surface [GO:0009986]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; protein kinase binding [GO:0019901]; acute inflammatory response to antigenic stimulus [GO:0002438]; adaptive immune response [GO:0002250]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immunological synapse formation [GO:0001771]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell proliferation [GO:0042102]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:17371992, ECO:0000269|PubMed:17601777, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:9013954}; Single-pass type I membrane protein {ECO:0000269|PubMed:17371992}. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938). {ECO:0000269|PubMed:15294938}.; SUBCELLULAR LOCATION: [Soluble CD6]: Secreted {ECO:0000269|PubMed:17601777}. Note=The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain. {ECO:0000305}.
P30260	reviewed	CDC27_HUMAN	Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)	CDC27 ANAPC3 D0S1430E D17S978E	Homo sapiens (Human)	824	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.	MISCELLANEOUS: [Isoform 2]: May be due to competing acceptor splice site. {ECO:0000305}.	anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	protein phosphatase binding [GO:0019903]	anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; protein phosphatase binding [GO:0019903]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}.
P30273	reviewed	FCERG_HUMAN	High affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (FcRgamma) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (FceRI gamma)	FCER1G	Homo sapiens (Human)	86	FUNCTION: Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation. {ECO:0000250|UniProtKB:P20491}.		antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; defense response to bacterium [GO:0042742]; Fc receptor mediated stimulatory signaling pathway [GO:0002431]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway [GO:0038094]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; interleukin-3-mediated signaling pathway [GO:0038156]; neutrophil activation involved in immune response [GO:0002283]; neutrophil chemotaxis [GO:0030593]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of phagocytosis [GO:0050766]; receptor internalization [GO:0031623]; regulation of platelet activation [GO:0010543]; T cell differentiation involved in immune response [GO:0002292]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; Fc-epsilon receptor I complex [GO:0032998]; Fc-gamma receptor III complex [GO:0033001]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	identical protein binding [GO:0042802]; IgE binding [GO:0019863]; IgE receptor activity [GO:0019767]; IgG binding [GO:0019864]; protein homodimerization activity [GO:0042803]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; Fc-epsilon receptor I complex [GO:0032998]; Fc-gamma receptor III complex [GO:0033001]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; identical protein binding [GO:0042802]; IgE binding [GO:0019863]; IgE receptor activity [GO:0019767]; IgG binding [GO:0019864]; protein homodimerization activity [GO:0042803]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; defense response to bacterium [GO:0042742]; Fc receptor mediated stimulatory signaling pathway [GO:0002431]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway [GO:0038094]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; interleukin-3-mediated signaling pathway [GO:0038156]; neutrophil activation involved in immune response [GO:0002283]; neutrophil chemotaxis [GO:0030593]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of phagocytosis [GO:0050766]; receptor internalization [GO:0031623]; regulation of platelet activation [GO:0010543]; T cell differentiation involved in immune response [GO:0002292]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:8611682}.
P30279	reviewed	CCND2_HUMAN	G1/S-specific cyclin-D2	CCND2	Homo sapiens (Human)	289	FUNCTION: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739, PubMed:18827403). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739, PubMed:18827403). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739, PubMed:18827403). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739, PubMed:18827403). {ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:8114739}.	MISCELLANEOUS: [Isoform 2]: Acts as proto-oncogene. Retains ability to bind CDK4, but unable to catalyze efficiently RB phosphorylation and inactivation. {ECO:0000269|PubMed:17873913}.	adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; cellular response to X-ray [GO:0071481]; G1/S transition of mitotic cell cycle [GO:0000082]; long-term memory [GO:0007616]; mitotic cell cycle phase transition [GO:0044772]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein phosphorylation [GO:0001934]	chromatin [GO:0000785]; cyclin D2-CDK4 complex [GO:0097129]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901]	chromatin [GO:0000785]; cyclin D2-CDK4 complex [GO:0097129]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901]; adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; cellular response to X-ray [GO:0071481]; G1/S transition of mitotic cell cycle [GO:0000082]; long-term memory [GO:0007616]; mitotic cell cycle phase transition [GO:0044772]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein phosphorylation [GO:0001934]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18827403}. Cytoplasm {ECO:0000269|PubMed:18827403}. Nucleus membrane {ECO:0000269|PubMed:18827403}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000269|PubMed:18827403}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17873913}.
P30281	reviewed	CCND3_HUMAN	G1/S-specific cyclin-D3	CCND3	Homo sapiens (Human)	292	FUNCTION: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739). Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892). Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120). {ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:8114739}.		cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic cell cycle phase transition [GO:0044772]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]; T cell proliferation [GO:0042098]	cyclin D3-CDK4 complex [GO:0097130]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901]	cyclin D3-CDK4 complex [GO:0097130]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901]; cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic cell cycle phase transition [GO:0044772]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15358120}. Cytoplasm {ECO:0000269|PubMed:15358120}.
P30291	reviewed	WEE1_HUMAN	Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)	WEE1	Homo sapiens (Human)	646	FUNCTION: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.		cell division [GO:0051301]; establishment of cell polarity [GO:0030010]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; neuron projection morphogenesis [GO:0048812]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; cell division [GO:0051301]; establishment of cell polarity [GO:0030010]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; neuron projection morphogenesis [GO:0048812]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Nucleus.
P30301	reviewed	MIP_HUMAN	Lens fiber major intrinsic protein (Aquaporin-0) (MIP26) (MP26)	MIP AQP0	Homo sapiens (Human)	263	FUNCTION: Water channel (PubMed:24120416). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (PubMed:24120416). {ECO:0000250|UniProtKB:Q6J8I9, ECO:0000269|PubMed:24120416}.		gap junction-mediated intercellular transport [GO:1990349]; lens development in camera-type eye [GO:0002088]; positive regulation of cell adhesion [GO:0045785]; protein homotetramerization [GO:0051289]; response to stimulus [GO:0050896]; visual perception [GO:0007601]; water transport [GO:0006833]	apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; gap junction [GO:0005921]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]; structural constituent of eye lens [GO:0005212]; water channel activity [GO:0015250]	apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; gap junction [GO:0005921]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; structural constituent of eye lens [GO:0005212]; water channel activity [GO:0015250]; gap junction-mediated intercellular transport [GO:1990349]; lens development in camera-type eye [GO:0002088]; positive regulation of cell adhesion [GO:0045785]; protein homotetramerization [GO:0051289]; response to stimulus [GO:0050896]; visual perception [GO:0007601]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23116563, ECO:0000269|PubMed:24120416, ECO:0000269|PubMed:25946197, ECO:0000269|PubMed:30790544}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6J8I9}. Cell junction, gap junction {ECO:0000269|PubMed:24120416}.
P30304	reviewed	MPIP1_HUMAN	M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)	CDC25A	Homo sapiens (Human)	524	FUNCTION: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.		cell division [GO:0051301]; cell population proliferation [GO:0008283]; cellular response to UV [GO:0034644]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; response to radiation [GO:0009314]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	phosphoprotein phosphatase activity [GO:0004721]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phosphoprotein phosphatase activity [GO:0004721]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein-folding chaperone binding [GO:0051087]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; cellular response to UV [GO:0034644]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; response to radiation [GO:0009314]	
P30305	reviewed	MPIP2_HUMAN	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)	CDC25B CDC25HU2	Homo sapiens (Human)	580	FUNCTION: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. {ECO:0000269|PubMed:17332740}.		cell division [GO:0051301]; female meiosis I [GO:0007144]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; oocyte maturation [GO:0001556]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; positive regulation of mitotic cell cycle [GO:0045931]; protein phosphorylation [GO:0006468]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	phosphoprotein phosphatase activity [GO:0004721]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; phosphoprotein phosphatase activity [GO:0004721]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; cell division [GO:0051301]; female meiosis I [GO:0007144]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; oocyte maturation [GO:0001556]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; positive regulation of mitotic cell cycle [GO:0045931]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15908796}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:15908796}.
P30307	reviewed	MPIP3_HUMAN	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)	CDC25C	Homo sapiens (Human)	473	FUNCTION: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. {ECO:0000269|PubMed:8119945}.		cell division [GO:0051301]; cell population proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic nuclear division [GO:0007088]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	phosphoprotein phosphatase activity [GO:0004721]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; WW domain binding [GO:0050699]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; phosphoprotein phosphatase activity [GO:0004721]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; WW domain binding [GO:0050699]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic nuclear division [GO:0007088]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14968113, ECO:0000269|PubMed:8119945}.
P30405	reviewed	PPIF_HUMAN	Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F)	PPIF CYP3	Homo sapiens (Human)	207	FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691). {ECO:0000250|UniProtKB:Q99KR7, ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:26387735}.		apoptotic mitochondrial changes [GO:0008637]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; mitochondrial outer membrane permeabilization involved in programmed cell death [GO:1902686]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of oxidative phosphorylation uncoupler activity [GO:2000276]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]; regulation of proton-transporting ATPase activity, rotational mechanism [GO:0010849]; response to ischemia [GO:0002931]	cytoplasm [GO:0005737]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; apoptotic mitochondrial changes [GO:0008637]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; mitochondrial outer membrane permeabilization involved in programmed cell death [GO:1902686]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of oxidative phosphorylation uncoupler activity [GO:2000276]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]; regulation of proton-transporting ATPase activity, rotational mechanism [GO:0010849]; response to ischemia [GO:0002931]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:10406942}.
P30411	reviewed	BKRB2_HUMAN	B2 bradykinin receptor (B2R) (BK-2 receptor)	BDKRB2 BKR2	Homo sapiens (Human)	391	FUNCTION: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:1314587, ECO:0000269|PubMed:1329734}.		arachidonic acid secretion [GO:0050482]; blood circulation [GO:0008015]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1990127]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1902239]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of vascular permeability [GO:0043114]; regulation of vasoconstriction [GO:0019229]; response to salt stress [GO:0009651]; smooth muscle contraction [GO:0006939]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasoconstriction [GO:0042310]; vasodilation [GO:0042311]	endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	bradykinin receptor activity [GO:0004947]; phosphatidylinositol phospholipase C activity [GO:0004435]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; type 1 angiotensin receptor binding [GO:0031702]	endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; bradykinin receptor activity [GO:0004947]; phosphatidylinositol phospholipase C activity [GO:0004435]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; type 1 angiotensin receptor binding [GO:0031702]; arachidonic acid secretion [GO:0050482]; blood circulation [GO:0008015]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1990127]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1902239]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of vascular permeability [GO:0043114]; regulation of vasoconstriction [GO:0019229]; response to salt stress [GO:0009651]; smooth muscle contraction [GO:0006939]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasoconstriction [GO:0042310]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:1314587}; Multi-pass membrane protein {ECO:0000255}.
P30414	reviewed	NKTR_HUMAN	NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase)	NKTR	Homo sapiens (Human)	1462	FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}.		protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8421688}.
P30419	reviewed	NMT1_HUMAN	Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (HsNMT1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) (Protein-lysine myristoyltransferase NMT1) (EC 2.3.1.-)	NMT1 NMT	Homo sapiens (Human)	496	FUNCTION: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:32686708, PubMed:34999170, PubMed:25255805, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017, PubMed:32111831). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017). {ECO:0000269|PubMed:22865860, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:32111831, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:34999170, ECO:0000269|PubMed:9353336, ECO:0000269|PubMed:9506952}.		cellular ketone metabolic process [GO:0042180]; in utero embryonic development [GO:0001701]; N-terminal peptidyl-glycine N-myristoylation [GO:0018008]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; protein localization to membrane [GO:0072657]; regulation of rhodopsin mediated signaling pathway [GO:0022400]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	glycylpeptide N-tetradecanoyltransferase activity [GO:0004379]; myristoyltransferase activity [GO:0019107]; peptidyl-lysine N6-myristoyltransferase activity [GO:0018030]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; glycylpeptide N-tetradecanoyltransferase activity [GO:0004379]; myristoyltransferase activity [GO:0019107]; peptidyl-lysine N6-myristoyltransferase activity [GO:0018030]; cellular ketone metabolic process [GO:0042180]; in utero embryonic development [GO:0001701]; N-terminal peptidyl-glycine N-myristoylation [GO:0018008]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; protein localization to membrane [GO:0072657]; regulation of rhodopsin mediated signaling pathway [GO:0022400]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9353336, ECO:0000269|PubMed:9506952}. Cytoplasm, cytosol {ECO:0000269|PubMed:9353336}. Membrane {ECO:0000269|PubMed:9506952}; Peripheral membrane protein {ECO:0000269|PubMed:9506952}. Note=Copurifies with ribosomes. {ECO:0000269|PubMed:9353336}.
P30511	reviewed	HLAF_HUMAN	HLA class I histocompatibility antigen, alpha chain F (CDA12) (HLA F antigen) (Leukocyte antigen F) (MHC class I antigen F)	HLA-F HLA-5.4 HLAF	Homo sapiens (Human)	346	FUNCTION: Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors (PubMed:28636952). Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production (PubMed:27455421). Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions (PubMed:24018270). May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses (PubMed:23851683). May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464). {ECO:0000269|PubMed:23851683, ECO:0000269|PubMed:24018270, ECO:0000269|PubMed:26928464, ECO:0000269|PubMed:27455421, ECO:0000269|PubMed:28636952}.		antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; antigen processing and presentation of exogenous peptide antigen via MHC class Ib [GO:0002477]; immune response [GO:0006955]; negative regulation of natural killer cell cytokine production [GO:0002728]; negative regulation of natural killer cell degranulation [GO:0043322]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of T cell cytokine production [GO:0002725]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class I protein complex [GO:0042612]; MHC class Ib protein complex [GO:0032398]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	14-3-3 protein binding [GO:0071889]; beta-2-microglobulin binding [GO:0030881]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]; TAP1 binding [GO:0046978]; TAP2 binding [GO:0046979]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class I protein complex [GO:0042612]; MHC class Ib protein complex [GO:0032398]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; 14-3-3 protein binding [GO:0071889]; beta-2-microglobulin binding [GO:0030881]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]; TAP1 binding [GO:0046978]; TAP2 binding [GO:0046979]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; antigen processing and presentation of exogenous peptide antigen via MHC class Ib [GO:0002477]; immune response [GO:0006955]; negative regulation of natural killer cell cytokine production [GO:0002728]; negative regulation of natural killer cell degranulation [GO:0043322]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of T cell cytokine production [GO:0002725]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16709803, ECO:0000269|PubMed:23851683, ECO:0000305|PubMed:27455421}; Single-pass type I membrane protein. Early endosome membrane {ECO:0000269|PubMed:23851683}. Lysosome membrane {ECO:0000269|PubMed:23851683}. Note=For cross-presentation transits from the cell surface through endosomal pathway to lysosomes, where the peptide is generated from internalized exogenous antigen. {ECO:0000269|PubMed:23851683}.
P30518	reviewed	V2R_HUMAN	Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor)	AVPR2 ADHR DIR DIR3 V2R	Homo sapiens (Human)	371	FUNCTION: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. {ECO:0000269|PubMed:19440390}.		activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; hemostasis [GO:0007599]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; renal water retention [GO:0003092]; response to cytokine [GO:0034097]; telencephalon development [GO:0021537]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	peptide binding [GO:0042277]; vasopressin receptor activity [GO:0005000]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; peptide binding [GO:0042277]; vasopressin receptor activity [GO:0005000]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; hemostasis [GO:0007599]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; renal water retention [GO:0003092]; response to cytokine [GO:0034097]; telencephalon development [GO:0021537]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23236378}; Multi-pass membrane protein {ECO:0000305}.
P30519	reviewed	HMOX2_HUMAN	Heme oxygenase 2 (HO-2) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 2 soluble form]	HMOX2 HO2	Homo sapiens (Human)	316	FUNCTION: [Heme oxygenase 2]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:1575508, ECO:0000269|PubMed:7890772}.; FUNCTION: [Heme oxygenase 2 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:7890772}.		heme catabolic process [GO:0042167]; heme oxidation [GO:0006788]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	heme binding [GO:0020037]; heme oxygenase (decyclizing) activity [GO:0004392]; metal ion binding [GO:0046872]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; heme binding [GO:0020037]; heme oxygenase (decyclizing) activity [GO:0004392]; metal ion binding [GO:0046872]; heme catabolic process [GO:0042167]; heme oxidation [GO:0006788]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305|PubMed:7890772}; Single-pass type IV membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:P09601}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P09601}; Single-pass type IV membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:P09601}.
P30520	reviewed	PURA2_HUMAN	Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2)	ADSS2 ADSS	Homo sapiens (Human)	456	FUNCTION: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. {ECO:0000250|UniProtKB:P46664}.		'de novo' AMP biosynthetic process [GO:0044208]; AMP biosynthetic process [GO:0006167]; aspartate metabolic process [GO:0006531]; cellular response to electrical stimulus [GO:0071257]; immune system process [GO:0002376]; IMP metabolic process [GO:0046040]; response to ammonium ion [GO:0060359]; response to purine-containing compound [GO:0014074]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	adenylosuccinate synthase activity [GO:0004019]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; adenylosuccinate synthase activity [GO:0004019]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301]; 'de novo' AMP biosynthetic process [GO:0044208]; AMP biosynthetic process [GO:0006167]; aspartate metabolic process [GO:0006531]; cellular response to electrical stimulus [GO:0071257]; immune system process [GO:0002376]; IMP metabolic process [GO:0046040]; response to ammonium ion [GO:0060359]; response to purine-containing compound [GO:0014074]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03127}. Mitochondrion {ECO:0000250|UniProtKB:A4Z6H1}. Note=Partially associated with particulate fractions.
P30530	reviewed	UFO_HUMAN	Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)	AXL UFO	Homo sapiens (Human)	894	FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210). {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:31311882}.		animal organ regeneration [GO:0031100]; blood vessel remodeling [GO:0001974]; cell maturation [GO:0048469]; cell migration [GO:0016477]; cellular response to extracellular stimulus [GO:0031668]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interferon-alpha [GO:0035457]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell differentiation [GO:0097028]; erythrocyte homeostasis [GO:0034101]; establishment of localization in cell [GO:0051649]; forebrain cell migration [GO:0021885]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; natural killer cell differentiation [GO:0001779]; negative regulation of apoptotic process [GO:0043066]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of lymphocyte activation [GO:0051250]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron migration [GO:0001764]; neutrophil clearance [GO:0097350]; ovulation cycle [GO:0042698]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; platelet activation [GO:0030168]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of pinocytosis [GO:0048549]; positive regulation of viral life cycle [GO:1903902]; response to axon injury [GO:0048678]; secretion by cell [GO:0032940]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vagina development [GO:0060068]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral entry into host cell [GO:0046718]	actin cytoskeleton [GO:0015629]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; myosin heavy chain binding [GO:0032036]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylserine binding [GO:0001786]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; virus receptor activity [GO:0001618]	actin cytoskeleton [GO:0015629]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; myosin heavy chain binding [GO:0032036]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylserine binding [GO:0001786]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; virus receptor activity [GO:0001618]; animal organ regeneration [GO:0031100]; blood vessel remodeling [GO:0001974]; cell maturation [GO:0048469]; cell migration [GO:0016477]; cellular response to extracellular stimulus [GO:0031668]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interferon-alpha [GO:0035457]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell differentiation [GO:0097028]; erythrocyte homeostasis [GO:0034101]; establishment of localization in cell [GO:0051649]; forebrain cell migration [GO:0021885]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; natural killer cell differentiation [GO:0001779]; negative regulation of apoptotic process [GO:0043066]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of lymphocyte activation [GO:0051250]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron migration [GO:0001764]; neutrophil clearance [GO:0097350]; ovulation cycle [GO:0042698]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; platelet activation [GO:0030168]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of pinocytosis [GO:0048549]; positive regulation of viral life cycle [GO:1903902]; response to axon injury [GO:0048678]; secretion by cell [GO:0032940]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vagina development [GO:0060068]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:7896447}; Single-pass type I membrane protein {ECO:0000269|PubMed:7896447}.
P30531	reviewed	SC6A1_HUMAN	Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)	SLC6A1 GABATR GABT1 GAT1	Homo sapiens (Human)	599	FUNCTION: Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity). {ECO:0000250|UniProtKB:P23978, ECO:0000250|UniProtKB:P31648, ECO:0000269|PubMed:30132828}.	MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.	associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid reuptake [GO:0051936]; inorganic anion import across plasma membrane [GO:0098658]; memory [GO:0007613]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; response to calcium ion [GO:0051592]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to inorganic substance [GO:0010035]; response to lead ion [GO:0010288]; response to purine-containing compound [GO:0014074]; response to sucrose [GO:0009744]; response to toxic substance [GO:0009636]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]; transport across blood-brain barrier [GO:0150104]	axon [GO:0030424]; cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sodium:chloride symporter activity [GO:0015378]	axon [GO:0030424]; cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sodium:chloride symporter activity [GO:0015378]; associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid reuptake [GO:0051936]; inorganic anion import across plasma membrane [GO:0098658]; memory [GO:0007613]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; response to calcium ion [GO:0051592]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to inorganic substance [GO:0010035]; response to lead ion [GO:0010288]; response to purine-containing compound [GO:0014074]; response to sucrose [GO:0009744]; response to toxic substance [GO:0009636]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P23978}; Multi-pass membrane protein {ECO:0000255}. Presynapse {ECO:0000250|UniProtKB:P31648}. Note=Localized at the presynaptic terminals of interneurons. {ECO:0000250|UniProtKB:P31648}.
P30532	reviewed	ACHA5_HUMAN	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5 NACHRA5	Homo sapiens (Human)	468	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.		behavioral response to nicotine [GO:0035095]; chemical synaptic transmission [GO:0007268]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]; behavioral response to nicotine [GO:0035095]; chemical synaptic transmission [GO:0007268]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
P30533	reviewed	AMRP_HUMAN	Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP)	LRPAP1 A2MRAP	Homo sapiens (Human)	357	FUNCTION: Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:7774585}.		amyloid-beta clearance by transcytosis [GO:0150093]; extracellular negative regulation of signal transduction [GO:1900116]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of protein binding [GO:0032091]; negative regulation of receptor internalization [GO:0002091]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; positive regulation of amyloid-beta clearance [GO:1900223]; regulation of receptor-mediated endocytosis [GO:0048259]; signal transduction [GO:0007165]	cell surface [GO:0009986]; cis-Golgi network [GO:0005801]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; rough endoplasmic reticulum lumen [GO:0048237]	amyloid-beta binding [GO:0001540]; heparin binding [GO:0008201]; lipase binding [GO:0035473]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; very-low-density lipoprotein particle receptor binding [GO:0070326]	cell surface [GO:0009986]; cis-Golgi network [GO:0005801]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; rough endoplasmic reticulum lumen [GO:0048237]; amyloid-beta binding [GO:0001540]; heparin binding [GO:0008201]; lipase binding [GO:0035473]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; very-low-density lipoprotein particle receptor binding [GO:0070326]; amyloid-beta clearance by transcytosis [GO:0150093]; extracellular negative regulation of signal transduction [GO:1900116]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of protein binding [GO:0032091]; negative regulation of receptor internalization [GO:0002091]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; positive regulation of amyloid-beta clearance [GO:1900223]; regulation of receptor-mediated endocytosis [GO:0048259]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Rough endoplasmic reticulum lumen {ECO:0000269|PubMed:7774585}. Endoplasmic reticulum-Golgi intermediate compartment lumen {ECO:0000269|PubMed:7774585}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:7774585}. Golgi apparatus lumen {ECO:0000269|PubMed:7774585}. Endosome lumen {ECO:0000269|PubMed:7774585}. Cell surface {ECO:0000269|PubMed:11384978}. Note=May be associated with receptors at the cell surface. {ECO:0000269|PubMed:11384978}.
P30536	reviewed	TSPO_HUMAN	Translocator protein (Mitochondrial benzodiazepine receptor) (PKBS) (Peripheral-type benzodiazepine receptor) (PBR)	TSPO BZRP MBR	Homo sapiens (Human)	169	FUNCTION: Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678). {ECO:0000250, ECO:0000269|PubMed:1847678, ECO:0000269|PubMed:24814875}.		adrenal gland development [GO:0030325]; behavioral response to pain [GO:0048266]; C21-steroid hormone biosynthetic process [GO:0006700]; cellular hypotonic response [GO:0071476]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to zinc ion [GO:0071294]; chloride transport [GO:0006821]; cholesterol homeostasis [GO:0042632]; contact inhibition [GO:0060242]; glial cell migration [GO:0008347]; heme biosynthetic process [GO:0006783]; maintenance of protein location in mitochondrion [GO:0072656]; monoatomic anion transport [GO:0006820]; negative regulation of ATP metabolic process [GO:1903579]; negative regulation of autophagy of mitochondrion [GO:1903147]; negative regulation of corticosterone secretion [GO:2000853]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of tumor necrosis factor production [GO:0032720]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein targeting to mitochondrion [GO:0006626]; regulation of cell population proliferation [GO:0042127]; regulation of cholesterol transport [GO:0032374]; regulation of steroid biosynthetic process [GO:0050810]; response to acetylcholine [GO:1905144]; response to manganese ion [GO:0010042]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to vitamin B1 [GO:0010266]; response to xenobiotic stimulus [GO:0009410]; steroid metabolic process [GO:0008202]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	androgen binding [GO:0005497]; benzodiazepine receptor activity [GO:0008503]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; transmembrane transporter binding [GO:0044325]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; androgen binding [GO:0005497]; benzodiazepine receptor activity [GO:0008503]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; transmembrane transporter binding [GO:0044325]; adrenal gland development [GO:0030325]; behavioral response to pain [GO:0048266]; C21-steroid hormone biosynthetic process [GO:0006700]; cellular hypotonic response [GO:0071476]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to zinc ion [GO:0071294]; chloride transport [GO:0006821]; cholesterol homeostasis [GO:0042632]; contact inhibition [GO:0060242]; glial cell migration [GO:0008347]; heme biosynthetic process [GO:0006783]; maintenance of protein location in mitochondrion [GO:0072656]; monoatomic anion transport [GO:0006820]; negative regulation of ATP metabolic process [GO:1903579]; negative regulation of autophagy of mitochondrion [GO:1903147]; negative regulation of corticosterone secretion [GO:2000853]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of tumor necrosis factor production [GO:0032720]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein targeting to mitochondrion [GO:0006626]; regulation of cell population proliferation [GO:0042127]; regulation of cholesterol transport [GO:0032374]; regulation of steroid biosynthetic process [GO:0050810]; response to acetylcholine [GO:1905144]; response to manganese ion [GO:0010042]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to vitamin B1 [GO:0010266]; response to xenobiotic stimulus [GO:0009410]; steroid metabolic process [GO:0008202]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:1847678}; Multi-pass membrane protein {ECO:0000269|PubMed:1847678}.
P30542	reviewed	AA1R_HUMAN	Adenosine receptor A1	ADORA1	Homo sapiens (Human)	326	FUNCTION: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; apoptotic signaling pathway [GO:0097190]; cell-cell signaling [GO:0007267]; cognition [GO:0050890]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; excitatory postsynaptic potential [GO:0060079]; fatty acid homeostasis [GO:0055089]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; leukocyte migration [GO:0050900]; lipid catabolic process [GO:0016042]; long-term synaptic depression [GO:0060292]; mucus secretion [GO:0070254]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of circadian sleep/wake cycle, non-REM sleep [GO:0042323]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of hormone secretion [GO:0046888]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of mucus secretion [GO:0070256]; negative regulation of neurotrophin production [GO:0032900]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; negative regulation of systemic arterial blood pressure [GO:0003085]; nervous system development [GO:0007399]; phagocytosis [GO:0006909]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of nucleoside transport [GO:0032244]; positive regulation of peptide secretion [GO:0002793]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of systemic arterial blood pressure [GO:0003084]; protein targeting to membrane [GO:0006612]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of glomerular filtration [GO:0003093]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of sensory perception of pain [GO:0051930]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to purine-containing compound [GO:0014074]; signal transduction [GO:0007165]; temperature homeostasis [GO:0001659]; triglyceride homeostasis [GO:0070328]; vasodilation [GO:0042311]	asymmetric synapse [GO:0032279]; axolemma [GO:0030673]; basolateral plasma membrane [GO:0016323]; calyx of Held [GO:0044305]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; terminal bouton [GO:0043195]	G protein-coupled adenosine receptor activity [GO:0001609]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; heat shock protein binding [GO:0031072]; heterotrimeric G-protein binding [GO:0032795]; protein heterodimerization activity [GO:0046982]; purine nucleoside binding [GO:0001883]	asymmetric synapse [GO:0032279]; axolemma [GO:0030673]; basolateral plasma membrane [GO:0016323]; calyx of Held [GO:0044305]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; terminal bouton [GO:0043195]; G protein-coupled adenosine receptor activity [GO:0001609]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; heat shock protein binding [GO:0031072]; heterotrimeric G-protein binding [GO:0032795]; protein heterodimerization activity [GO:0046982]; purine nucleoside binding [GO:0001883]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; apoptotic signaling pathway [GO:0097190]; cell-cell signaling [GO:0007267]; cognition [GO:0050890]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; excitatory postsynaptic potential [GO:0060079]; fatty acid homeostasis [GO:0055089]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; leukocyte migration [GO:0050900]; lipid catabolic process [GO:0016042]; long-term synaptic depression [GO:0060292]; mucus secretion [GO:0070254]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of circadian sleep/wake cycle, non-REM sleep [GO:0042323]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of hormone secretion [GO:0046888]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of mucus secretion [GO:0070256]; negative regulation of neurotrophin production [GO:0032900]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; negative regulation of systemic arterial blood pressure [GO:0003085]; nervous system development [GO:0007399]; phagocytosis [GO:0006909]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of nucleoside transport [GO:0032244]; positive regulation of peptide secretion [GO:0002793]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of systemic arterial blood pressure [GO:0003084]; protein targeting to membrane [GO:0006612]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of glomerular filtration [GO:0003093]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of sensory perception of pain [GO:0051930]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to purine-containing compound [GO:0014074]; signal transduction [GO:0007165]; temperature homeostasis [GO:0001659]; triglyceride homeostasis [GO:0070328]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27134041}; Multi-pass membrane protein.
P30550	reviewed	GRPR_HUMAN	Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)	GRPR	Homo sapiens (Human)	384	FUNCTION: Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). {ECO:0000250|UniProtKB:P21729, ECO:0000269|PubMed:1655761}.		G protein-coupled receptor signaling pathway [GO:0007186]; learning or memory [GO:0007611]; motor behavior [GO:0061744]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of respiratory gaseous exchange [GO:1903942]; psychomotor behavior [GO:0036343]; regulation of cell population proliferation [GO:0042127]; response to external biotic stimulus [GO:0043207]; social behavior [GO:0035176]	plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]	plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; G protein-coupled receptor signaling pathway [GO:0007186]; learning or memory [GO:0007611]; motor behavior [GO:0061744]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of respiratory gaseous exchange [GO:1903942]; psychomotor behavior [GO:0036343]; regulation of cell population proliferation [GO:0042127]; response to external biotic stimulus [GO:0043207]; social behavior [GO:0035176]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1655761}; Multi-pass membrane protein {ECO:0000255}.
P30556	reviewed	AGTR1_HUMAN	Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor)	AGTR1 AGTR1A AGTR1B AT2R1 AT2R1B	Homo sapiens (Human)	359	FUNCTION: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:1567413, PubMed:8987975, PubMed:15611106, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:15611106). {ECO:0000269|PubMed:15611106, ECO:0000269|PubMed:1567413, ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768, ECO:0000269|PubMed:8987975}.; FUNCTION: (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis. {ECO:0000269|PubMed:33713620}.		angiotensin-activated signaling pathway [GO:0038166]; blood vessel diameter maintenance [GO:0097746]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; kidney development [GO:0001822]; low-density lipoprotein particle remodeling [GO:0034374]; maintenance of blood vessel diameter homeostasis by renin-angiotensin [GO:0002034]; phospholipase C-activating angiotensin-activated signaling pathway [GO:0086097]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of NAD(P)H oxidase activity [GO:0033864]; positive regulation of phospholipase A2 activity [GO:0032430]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; regulation of inflammatory response [GO:0050727]; regulation of renal sodium excretion [GO:0035813]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; regulation of vasoconstriction [GO:0019229]; renin-angiotensin regulation of aldosterone production [GO:0002018]; Rho protein signal transduction [GO:0007266]; viral entry into host cell [GO:0046718]	membrane [GO:0016020]; plasma membrane [GO:0005886]	angiotensin type I receptor activity [GO:0001596]; angiotensin type II receptor activity [GO:0004945]; bradykinin receptor binding [GO:0031711]; protein heterodimerization activity [GO:0046982]	membrane [GO:0016020]; plasma membrane [GO:0005886]; angiotensin type I receptor activity [GO:0001596]; angiotensin type II receptor activity [GO:0004945]; bradykinin receptor binding [GO:0031711]; protein heterodimerization activity [GO:0046982]; angiotensin-activated signaling pathway [GO:0038166]; blood vessel diameter maintenance [GO:0097746]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; kidney development [GO:0001822]; low-density lipoprotein particle remodeling [GO:0034374]; maintenance of blood vessel diameter homeostasis by renin-angiotensin [GO:0002034]; phospholipase C-activating angiotensin-activated signaling pathway [GO:0086097]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of NAD(P)H oxidase activity [GO:0033864]; positive regulation of phospholipase A2 activity [GO:0032430]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; regulation of inflammatory response [GO:0050727]; regulation of renal sodium excretion [GO:0035813]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; regulation of vasoconstriction [GO:0019229]; renin-angiotensin regulation of aldosterone production [GO:0002018]; Rho protein signal transduction [GO:0007266]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33713620}; Multi-pass membrane protein {ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768}.
P30559	reviewed	OXYR_HUMAN	Oxytocin receptor (OT-R)	OXTR	Homo sapiens (Human)	389	FUNCTION: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.		cell surface receptor signaling pathway [GO:0007166]; cellular response to hormone stimulus [GO:0032870]; digestive tract development [GO:0048565]; eating behavior [GO:0042755]; ERK1 and ERK2 cascade [GO:0070371]; estrous cycle [GO:0044849]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; lactation [GO:0007595]; maternal behavior [GO:0042711]; maternal process involved in parturition [GO:0060137]; memory [GO:0007613]; muscle contraction [GO:0006936]; positive regulation of blood pressure [GO:0045777]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of norepinephrine secretion [GO:0010701]; positive regulation of penile erection [GO:0060406]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of uterine smooth muscle contraction [GO:0070474]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; response to amphetamine [GO:0001975]; response to anoxia [GO:0034059]; response to cocaine [GO:0042220]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; sperm ejaculation [GO:0042713]; suckling behavior [GO:0001967]; telencephalon development [GO:0021537]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	oxytocin receptor activity [GO:0004990]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; vasopressin receptor activity [GO:0005000]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; oxytocin receptor activity [GO:0004990]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; vasopressin receptor activity [GO:0005000]; cell surface receptor signaling pathway [GO:0007166]; cellular response to hormone stimulus [GO:0032870]; digestive tract development [GO:0048565]; eating behavior [GO:0042755]; ERK1 and ERK2 cascade [GO:0070371]; estrous cycle [GO:0044849]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; lactation [GO:0007595]; maternal behavior [GO:0042711]; maternal process involved in parturition [GO:0060137]; memory [GO:0007613]; muscle contraction [GO:0006936]; positive regulation of blood pressure [GO:0045777]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of norepinephrine secretion [GO:0010701]; positive regulation of penile erection [GO:0060406]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of uterine smooth muscle contraction [GO:0070474]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; response to amphetamine [GO:0001975]; response to anoxia [GO:0034059]; response to cocaine [GO:0042220]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; sperm ejaculation [GO:0042713]; suckling behavior [GO:0001967]; telencephalon development [GO:0021537]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P30566	reviewed	PUR8_HUMAN	Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase)	ADSL AMPS	Homo sapiens (Human)	484	FUNCTION: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}.	MISCELLANEOUS: [Isoform 2]: Lacks enzymatic activity. {ECO:0000305}.	'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; aerobic respiration [GO:0009060]; AMP biosynthetic process [GO:0006167]; AMP salvage [GO:0044209]; GMP biosynthetic process [GO:0006177]; purine nucleotide biosynthetic process [GO:0006164]; response to hypoxia [GO:0001666]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]	cytosol [GO:0005829]; protein-containing complex [GO:0032991]	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity [GO:0070626]; identical protein binding [GO:0042802]; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [GO:0004018]	cytosol [GO:0005829]; protein-containing complex [GO:0032991]; (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity [GO:0070626]; identical protein binding [GO:0042802]; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [GO:0004018]; 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; aerobic respiration [GO:0009060]; AMP biosynthetic process [GO:0006167]; AMP salvage [GO:0044209]; GMP biosynthetic process [GO:0006177]; purine nucleotide biosynthetic process [GO:0006164]; response to hypoxia [GO:0001666]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]	
P30613	reviewed	KPYR_HUMAN	Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase)	PKLR PK1 PKL	Homo sapiens (Human)	574	FUNCTION: Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis. {ECO:0000269|PubMed:11960989}.	MISCELLANEOUS: There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. L type is major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues.	cellular response to epinephrine stimulus [GO:0071872]; cellular response to insulin stimulus [GO:0032869]; glycolytic process [GO:0006096]; phosphorylation [GO:0016310]; pyruvate biosynthetic process [GO:0042866]; response to ATP [GO:0033198]; response to cAMP [GO:0051591]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to metal ion [GO:0010038]; response to nutrient [GO:0007584]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; pyruvate kinase complex [GO:1902912]	ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; monosaccharide binding [GO:0048029]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; pyruvate kinase complex [GO:1902912]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; monosaccharide binding [GO:0048029]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to insulin stimulus [GO:0032869]; glycolytic process [GO:0006096]; phosphorylation [GO:0016310]; pyruvate biosynthetic process [GO:0042866]; response to ATP [GO:0033198]; response to cAMP [GO:0051591]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to metal ion [GO:0010038]; response to nutrient [GO:0007584]	
P30622	reviewed	CLIP1_HUMAN	CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin)	CLIP1 CYLN1 RSN	Homo sapiens (Human)	1438	FUNCTION: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.		cytoplasmic microtubule organization [GO:0031122]; microtubule bundle formation [GO:0001578]; mitotic cell cycle [GO:0000278]; positive regulation of microtubule polymerization [GO:0031116]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; kinetochore [GO:0000776]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; ruffle [GO:0001726]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; kinetochore [GO:0000776]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; ruffle [GO:0001726]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]; cytoplasmic microtubule organization [GO:0031122]; microtubule bundle formation [GO:0001578]; mitotic cell cycle [GO:0000278]; positive regulation of microtubule polymerization [GO:0031116]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17889670, ECO:0000269|PubMed:21646404}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12433698}; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle {ECO:0000269|PubMed:12433698}. Note=Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698). {ECO:0000250|UniProtKB:Q922J3, ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17889670, ECO:0000269|PubMed:21646404}.
P30626	reviewed	SORCN_HUMAN	Sorcin (22 kDa protein) (CP-22) (CP22) (V19)	SRI	Homo sapiens (Human)	198	FUNCTION: Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269|PubMed:17699613}.	MISCELLANEOUS: This protein is encoded by an amplified gene in multidrug-resistant cells.; MISCELLANEOUS: This protein has been shown to bind calcium with high affinity.	action potential [GO:0001508]; calcium ion transport [GO:0006816]; heart development [GO:0007507]; intracellular sequestering of iron ion [GO:0006880]; muscle organ development [GO:0007517]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of heart rate [GO:0010459]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of heart contraction [GO:0008016]; regulation of high voltage-gated calcium channel activity [GO:1901841]; regulation of relaxation of muscle [GO:1901077]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of striated muscle contraction [GO:0006942]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; T-tubule [GO:0030315]; Z disc [GO:0030018]	calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; T-tubule [GO:0030315]; Z disc [GO:0030018]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; action potential [GO:0001508]; calcium ion transport [GO:0006816]; heart development [GO:0007507]; intracellular sequestering of iron ion [GO:0006880]; muscle organ development [GO:0007517]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of heart rate [GO:0010459]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of heart contraction [GO:0008016]; regulation of high voltage-gated calcium channel activity [GO:1901841]; regulation of relaxation of muscle [GO:1901077]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of striated muscle contraction [GO:0006942]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.
P30679	reviewed	GNA15_HUMAN	Guanine nucleotide-binding protein subunit alpha-15 (G alpha-15) (G-protein subunit alpha-15) (Epididymis tissue protein Li 17E) (Guanine nucleotide-binding protein subunit alpha-16) (G alpha-16) (G-protein subunit alpha-16)	GNA15 GNA16	Homo sapiens (Human)	374	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.		action potential [GO:0001508]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; action potential [GO:0001508]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	
P30711	reviewed	GSTT1_HUMAN	Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1) (Glutathione transferase T1-1)	GSTT1	Homo sapiens (Human)	240	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. {ECO:0000269|PubMed:16298388, ECO:0000269|PubMed:20097269}.		glutathione metabolic process [GO:0006749]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; glutathione metabolic process [GO:0006749]	SUBCELLULAR LOCATION: Cytoplasm.
P30740	reviewed	ILEU_HUMAN	Leukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1)	SERPINB1 ELANH2 MNEI PI2	Homo sapiens (Human)	379	FUNCTION: Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651). {ECO:0000269|PubMed:11747453, ECO:0000269|PubMed:23269243, ECO:0000269|PubMed:26701651, ECO:0000269|PubMed:30692621}.		negative regulation of endopeptidase activity [GO:0010951]; negative regulation of interleukin-1 beta production [GO:0032691]; type B pancreatic cell proliferation [GO:0044342]	collagen-containing extracellular matrix [GO:0062023]; cytolytic granule [GO:0044194]; cytoplasmic ribonucleoprotein granule [GO:0036464]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]	peptidase inhibitor activity [GO:0030414]; serine-type endopeptidase inhibitor activity [GO:0004867]	collagen-containing extracellular matrix [GO:0062023]; cytolytic granule [GO:0044194]; cytoplasmic ribonucleoprotein granule [GO:0036464]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]; peptidase inhibitor activity [GO:0030414]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of interleukin-1 beta production [GO:0032691]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26701651}. Cytoplasm {ECO:0000269|PubMed:23269243}. Cytolytic granule {ECO:0000269|PubMed:23269243}. Early endosome {ECO:0000269|PubMed:23269243}.
P30793	reviewed	GCH1_HUMAN	GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I)	GCH1 DYT5 GCH	Homo sapiens (Human)	250	FUNCTION: Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. {ECO:0000269|PubMed:12176133, ECO:0000269|PubMed:16338639, ECO:0000269|PubMed:17057711, ECO:0000269|PubMed:8068008, ECO:0000269|PubMed:9445252}.		7,8-dihydroneopterin 3'-triphosphate biosynthetic process [GO:0035998]; dopamine biosynthetic process [GO:0042416]; negative regulation of blood pressure [GO:0045776]; neuromuscular process controlling posture [GO:0050884]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of heart rate [GO:0010460]; positive regulation of nitric-oxide synthase activity [GO:0051000]; protein-containing complex assembly [GO:0065003]; pteridine-containing compound biosynthetic process [GO:0042559]; regulation of blood pressure [GO:0008217]; regulation of lung blood pressure [GO:0014916]; regulation of removal of superoxide radicals [GO:2000121]; response to lipopolysaccharide [GO:0032496]; response to pain [GO:0048265]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654]; vasodilation [GO:0042311]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; neuron projection terminus [GO:0044306]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTP cyclohydrolase I activity [GO:0003934]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; translation initiation factor binding [GO:0031369]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; neuron projection terminus [GO:0044306]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTP cyclohydrolase I activity [GO:0003934]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; translation initiation factor binding [GO:0031369]; zinc ion binding [GO:0008270]; 7,8-dihydroneopterin 3'-triphosphate biosynthetic process [GO:0035998]; dopamine biosynthetic process [GO:0042416]; negative regulation of blood pressure [GO:0045776]; neuromuscular process controlling posture [GO:0050884]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of heart rate [GO:0010460]; positive regulation of nitric-oxide synthase activity [GO:0051000]; protein-containing complex assembly [GO:0065003]; pteridine-containing compound biosynthetic process [GO:0042559]; regulation of blood pressure [GO:0008217]; regulation of lung blood pressure [GO:0014916]; regulation of removal of superoxide radicals [GO:2000121]; response to lipopolysaccharide [GO:0032496]; response to pain [GO:0048265]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12176133, ECO:0000269|PubMed:16778797, ECO:0000269|PubMed:2463916}. Nucleus {ECO:0000269|PubMed:16778797}.
P30825	reviewed	CTR1_HUMAN	High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter)	SLC7A1 ATRC1 ERR REC1L	Homo sapiens (Human)	629	FUNCTION: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. {ECO:0000269|PubMed:10485994, ECO:0000269|PubMed:9174363}.		amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-histidine import across plasma membrane [GO:1903810]; L-ornithine transmembrane transport [GO:1903352]; lysine transport [GO:0015819]; ornithine transport [GO:0015822]; positive regulation of T cell proliferation [GO:0042102]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-arginine transmembrane transporter activity [GO:0061459]; L-histidine transmembrane transporter activity [GO:0005290]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]; virus receptor activity [GO:0001618]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-arginine transmembrane transporter activity [GO:0061459]; L-histidine transmembrane transporter activity [GO:0005290]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]; virus receptor activity [GO:0001618]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-histidine import across plasma membrane [GO:1903810]; L-ornithine transmembrane transport [GO:1903352]; lysine transport [GO:0015819]; ornithine transport [GO:0015822]; positive regulation of T cell proliferation [GO:0042102]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q09143}; Multi-pass membrane protein {ECO:0000255}.
P30837	reviewed	AL1B1_HUMAN	Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1)	ALDH1B1 ALDH5 ALDHX	Homo sapiens (Human)	517	FUNCTION: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.		carbohydrate metabolic process [GO:0005975]; ethanol catabolic process [GO:0006068]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	aldehyde dehydrogenase (NAD+) activity [GO:0004029]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; NAD binding [GO:0051287]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; NAD binding [GO:0051287]; carbohydrate metabolic process [GO:0005975]; ethanol catabolic process [GO:0006068]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P30838	reviewed	AL3A1_HUMAN	Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (ALDHIII) (Aldehyde dehydrogenase 3) (Aldehyde dehydrogenase family 3 member A1)	ALDH3A1 ALDH3	Homo sapiens (Human)	453	FUNCTION: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). {ECO:0000250|UniProtKB:P47739, ECO:0000269|PubMed:1737758, ECO:0000305}.		cellular aldehyde metabolic process [GO:0006081]; lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479]; cellular aldehyde metabolic process [GO:0006081]; lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47739}.
P30872	reviewed	SSR1_HUMAN	Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R) (SST1) (SRIF-2)	SSTR1	Homo sapiens (Human)	391	FUNCTION: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.		cellular response to estradiol stimulus [GO:0071392]; cellular response to leukemia inhibitory factor [GO:1990830]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glutamate receptor signaling pathway [GO:0007215]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; response to starvation [GO:0042594]; spermatogenesis [GO:0007283]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]	neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994]; cellular response to estradiol stimulus [GO:0071392]; cellular response to leukemia inhibitory factor [GO:1990830]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glutamate receptor signaling pathway [GO:0007215]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; response to starvation [GO:0042594]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P30874	reviewed	SSR2_HUMAN	Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SST2) (SRIF-1)	SSTR2	Homo sapiens (Human)	369	FUNCTION: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. {ECO:0000269|PubMed:15231824, ECO:0000269|PubMed:18653781, ECO:0000269|PubMed:19434240, ECO:0000269|PubMed:22495673, ECO:0000269|PubMed:22932785}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucocorticoid stimulus [GO:0071385]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; peristalsis [GO:0030432]; response to starvation [GO:0042594]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	neuropeptide binding [GO:0042923]; PDZ domain binding [GO:0030165]; somatostatin receptor activity [GO:0004994]	cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; neuropeptide binding [GO:0042923]; PDZ domain binding [GO:0030165]; somatostatin receptor activity [GO:0004994]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucocorticoid stimulus [GO:0071385]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; peristalsis [GO:0030432]; response to starvation [GO:0042594]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
P30876	reviewed	RPB2_HUMAN	DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2)	POLR2B	Homo sapiens (Human)	1174	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.	MISCELLANEOUS: The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity). {ECO:0000250}.	transcription by RNA polymerase II [GO:0006366]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549]; RNA binding [GO:0003723]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549]; RNA binding [GO:0003723]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
P30926	reviewed	ACHB4_HUMAN	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	Homo sapiens (Human)	498	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.		behavioral response to nicotine [GO:0035095]; locomotory behavior [GO:0007626]; monoatomic ion transport [GO:0006811]; neuronal action potential [GO:0019228]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of neurotransmitter secretion [GO:0046928]; regulation of smooth muscle contraction [GO:0006940]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated channel complex [GO:0005892]; cholinergic synapse [GO:0098981]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; specific granule membrane [GO:0035579]; synapse [GO:0045202]; tertiary granule membrane [GO:0070821]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]	acetylcholine-gated channel complex [GO:0005892]; cholinergic synapse [GO:0098981]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; specific granule membrane [GO:0035579]; synapse [GO:0045202]; tertiary granule membrane [GO:0070821]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]; behavioral response to nicotine [GO:0035095]; locomotory behavior [GO:0007626]; monoatomic ion transport [GO:0006811]; neuronal action potential [GO:0019228]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of neurotransmitter secretion [GO:0046928]; regulation of smooth muscle contraction [GO:0006940]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
P30939	reviewed	5HT1F_HUMAN	5-hydroxytryptamine receptor 1F (5-HT-1F) (5-HT1F) (Serotonin receptor 1F)	HTR1F HTR1EL	Homo sapiens (Human)	366	FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:21422162, ECO:0000269|PubMed:8380639, ECO:0000269|PubMed:8384716}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8380639, ECO:0000269|PubMed:8384716}; Multi-pass membrane protein {ECO:0000269|PubMed:8380639, ECO:0000269|PubMed:8384716}.
P30968	reviewed	GNRHR_HUMAN	Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R)	GNRHR GRHR	Homo sapiens (Human)	328	FUNCTION: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.		cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; gonadotropin secretion [GO:0032274]	membrane [GO:0016020]; plasma membrane [GO:0005886]	gonadotropin-releasing hormone receptor activity [GO:0004968]; peptide binding [GO:0042277]	membrane [GO:0016020]; plasma membrane [GO:0005886]; gonadotropin-releasing hormone receptor activity [GO:0004968]; peptide binding [GO:0042277]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; gonadotropin secretion [GO:0032274]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P30988	reviewed	CALCR_HUMAN	Calcitonin receptor (CT-R)	CALCR	Homo sapiens (Human)	474	FUNCTION: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.; FUNCTION: [Isoform 2]: Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase (PubMed:7476993). Does not undergo receptor internalization following ligand binding (PubMed:7476993). {ECO:0000269|PubMed:7476993}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor signaling pathway [GO:0097647]; cell surface receptor signaling pathway [GO:0007166]; cross-receptor inhibition within G protein-coupled receptor heterodimer [GO:0038041]; negative regulation of ossification [GO:0030279]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase A signaling [GO:0010739]; regulation of mRNA stability [GO:0043488]; response to amyloid-beta [GO:1904645]; response to glucocorticoid [GO:0051384]	acrosomal vesicle [GO:0001669]; amylin receptor complex 1 [GO:0150056]; amylin receptor complex 2 [GO:0150057]; amylin receptor complex 3 [GO:0150058]; axon [GO:0030424]; cilium [GO:0005929]; plasma membrane [GO:0005886]	amylin receptor activity [GO:0097643]; amyloid-beta binding [GO:0001540]; calcitonin binding [GO:0032841]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948]	acrosomal vesicle [GO:0001669]; amylin receptor complex 1 [GO:0150056]; amylin receptor complex 2 [GO:0150057]; amylin receptor complex 3 [GO:0150058]; axon [GO:0030424]; cilium [GO:0005929]; plasma membrane [GO:0005886]; amylin receptor activity [GO:0097643]; amyloid-beta binding [GO:0001540]; calcitonin binding [GO:0032841]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor signaling pathway [GO:0097647]; cell surface receptor signaling pathway [GO:0007166]; cross-receptor inhibition within G protein-coupled receptor heterodimer [GO:0038041]; negative regulation of ossification [GO:0030279]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase A signaling [GO:0010739]; regulation of mRNA stability [GO:0043488]; response to amyloid-beta [GO:1904645]; response to glucocorticoid [GO:0051384]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P30989	reviewed	NTR1_HUMAN	Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH)	NTSR1 NTRR	Homo sapiens (Human)	418	FUNCTION: G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). {ECO:0000269|PubMed:21725197, ECO:0000269|PubMed:23140271, ECO:0000269|PubMed:8381365}.		adult locomotory behavior [GO:0008344]; chemical synaptic transmission [GO:0007268]; D-aspartate import across plasma membrane [GO:0070779]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway [GO:0007186]; inositol phosphate catabolic process [GO:0071545]; L-glutamate import across plasma membrane [GO:0098712]; learning [GO:0007612]; negative regulation of apoptotic process [GO:0043066]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; positive regulation of apoptotic process [GO:0043065]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of membrane depolarization [GO:0003254]; regulation of respiratory gaseous exchange [GO:0043576]; response to lipid [GO:0033993]; temperature homeostasis [GO:0001659]	cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; symmetric synapse [GO:0032280]; terminal bouton [GO:0043195]	G protein-coupled neurotensin receptor activity [GO:0016492]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; symmetric synapse [GO:0032280]; terminal bouton [GO:0043195]; G protein-coupled neurotensin receptor activity [GO:0016492]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; adult locomotory behavior [GO:0008344]; chemical synaptic transmission [GO:0007268]; D-aspartate import across plasma membrane [GO:0070779]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway [GO:0007186]; inositol phosphate catabolic process [GO:0071545]; L-glutamate import across plasma membrane [GO:0098712]; learning [GO:0007612]; negative regulation of apoptotic process [GO:0043066]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; positive regulation of apoptotic process [GO:0043065]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of membrane depolarization [GO:0003254]; regulation of respiratory gaseous exchange [GO:0043576]; response to lipid [GO:0033993]; temperature homeostasis [GO:0001659]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8381365}; Multi-pass membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:21725197}. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000269|PubMed:21725197}.
P30990	reviewed	NEUT_HUMAN	Neurotensin/neuromedin N [Cleaved into: Large neuromedin N (NmN-125); Neuromedin N (NN) (NmN); Neurotensin (NT); Tail peptide]	NTS	Homo sapiens (Human)	170	FUNCTION: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.		blood vessel diameter maintenance [GO:0097746]; negative regulation of gene expression [GO:0010629]; neuropeptide signaling pathway [GO:0007218]; positive regulation of gene expression [GO:0010628]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; signal transduction [GO:0007165]	axon terminus [GO:0043679]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; transport vesicle [GO:0030133]	neuropeptide hormone activity [GO:0005184]; neuropeptide receptor binding [GO:0071855]; receptor ligand activity [GO:0048018]	axon terminus [GO:0043679]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; transport vesicle [GO:0030133]; neuropeptide hormone activity [GO:0005184]; neuropeptide receptor binding [GO:0071855]; receptor ligand activity [GO:0048018]; blood vessel diameter maintenance [GO:0097746]; negative regulation of gene expression [GO:0010629]; neuropeptide signaling pathway [GO:0007218]; positive regulation of gene expression [GO:0010628]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Packaged within secretory vesicles.
P31025	reviewed	LCN1_HUMAN	Lipocalin-1 (Tear lipocalin) (Tlc) (Tear prealbumin) (TP) (von Ebner gland protein) (VEG protein)	LCN1 VEGP	Homo sapiens (Human)	176	FUNCTION: Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.		proteolysis [GO:0006508]; response to stimulus [GO:0050896]; retina homeostasis [GO:0001895]; sensory perception of taste [GO:0050909]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	chloride ion binding [GO:0031404]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; signaling receptor binding [GO:0005102]; small molecule binding [GO:0036094]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; chloride ion binding [GO:0031404]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; signaling receptor binding [GO:0005102]; small molecule binding [GO:0036094]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]; response to stimulus [GO:0050896]; retina homeostasis [GO:0001895]; sensory perception of taste [GO:0050909]	SUBCELLULAR LOCATION: Secreted.
P31040	reviewed	SDHA_HUMAN	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp)	SDHA SDH2 SDHF	Homo sapiens (Human)	664	FUNCTION: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225). {ECO:0000269|PubMed:20484225, ECO:0000305|PubMed:24781757}.		mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; nervous system development [GO:0007399]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory electron transport chain [GO:0022904]; succinate metabolic process [GO:0006105]; tricarboxylic acid cycle [GO:0006099]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [GO:0005749]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; fumarate reductase (menaquinone) [GO:0102040]; succinate dehydrogenase (ubiquinone) activity [GO:0008177]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [GO:0005749]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; fumarate reductase (menaquinone) [GO:0102040]; succinate dehydrogenase (ubiquinone) activity [GO:0008177]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; nervous system development [GO:0007399]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory electron transport chain [GO:0022904]; succinate metabolic process [GO:0006105]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q0QF01}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q0QF01}; Matrix side {ECO:0000250|UniProtKB:Q0QF01}.
P31146	reviewed	COR1A_HUMAN	Coronin-1A (Coronin-like protein A) (Clipin-A) (Coronin-like protein p57) (Tryptophan aspartate-containing coat protein) (TACO)	CORO1A CORO1	Homo sapiens (Human)	461	FUNCTION: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. {ECO:0000269|PubMed:10338208}.		actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; calcium ion transport [GO:0006816]; cell migration [GO:0016477]; cell-substrate adhesion [GO:0031589]; cellular response to interleukin-4 [GO:0071353]; early endosome to recycling endosome transport [GO:0061502]; epithelial cell migration [GO:0010631]; homeostasis of number of cells within a tissue [GO:0048873]; innate immune response [GO:0045087]; leukocyte chemotaxis [GO:0030595]; natural killer cell degranulation [GO:0043320]; negative regulation of actin nucleation [GO:0051126]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of vesicle fusion [GO:0031339]; nerve growth factor signaling pathway [GO:0038180]; neuron apoptotic process [GO:0051402]; phagocytosis [GO:0006909]; phagolysosome assembly [GO:0001845]; positive chemotaxis [GO:0050918]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; thymocyte migration [GO:0072679]; uropod organization [GO:0032796]; vesicle fusion [GO:0006906]	actin filament [GO:0005884]; axon [GO:0030424]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; lamellipodium [GO:0030027]; membrane [GO:0016020]; phagocytic cup [GO:0001891]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; cytoskeletal protein binding [GO:0008092]; myosin heavy chain binding [GO:0032036]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]	actin filament [GO:0005884]; axon [GO:0030424]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; lamellipodium [GO:0030027]; membrane [GO:0016020]; phagocytic cup [GO:0001891]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; cytoskeletal protein binding [GO:0008092]; myosin heavy chain binding [GO:0032036]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; calcium ion transport [GO:0006816]; cell migration [GO:0016477]; cell-substrate adhesion [GO:0031589]; cellular response to interleukin-4 [GO:0071353]; early endosome to recycling endosome transport [GO:0061502]; epithelial cell migration [GO:0010631]; homeostasis of number of cells within a tissue [GO:0048873]; innate immune response [GO:0045087]; leukocyte chemotaxis [GO:0030595]; natural killer cell degranulation [GO:0043320]; negative regulation of actin nucleation [GO:0051126]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of vesicle fusion [GO:0031339]; nerve growth factor signaling pathway [GO:0038180]; neuron apoptotic process [GO:0051402]; phagocytosis [GO:0006909]; phagolysosome assembly [GO:0001845]; positive chemotaxis [GO:0050918]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; thymocyte migration [GO:0072679]; uropod organization [GO:0032796]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity). {ECO:0000250}.
P31150	reviewed	GDIA_HUMAN	Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4)	GDI1 GDIL OPHN2 RABGDIA XAP4	Homo sapiens (Human)	447	FUNCTION: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. {ECO:0000269|PubMed:23815289}.		negative regulation of axonogenesis [GO:0050771]; negative regulation of protein targeting to membrane [GO:0090315]; positive regulation of axon extension [GO:0045773]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; response to calcium ion [GO:0051592]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; midbody [GO:0030496]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; presynaptic cytosol [GO:0099523]; protein-containing complex [GO:0032991]	GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; Rab GDP-dissociation inhibitor activity [GO:0005093]; small GTPase binding [GO:0031267]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; midbody [GO:0030496]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; presynaptic cytosol [GO:0099523]; protein-containing complex [GO:0032991]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; Rab GDP-dissociation inhibitor activity [GO:0005093]; small GTPase binding [GO:0031267]; negative regulation of axonogenesis [GO:0050771]; negative regulation of protein targeting to membrane [GO:0090315]; positive regulation of axon extension [GO:0045773]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; response to calcium ion [GO:0051592]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19570034}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19570034}.
P31151	reviewed	S10A7_HUMAN	Protein S100-A7 (Psoriasin) (S100 calcium-binding protein A7)	S100A7 PSOR1 S100A7C	Homo sapiens (Human)	101			angiogenesis [GO:0001525]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granulocyte chemotaxis [GO:0071624]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of T cell chemotaxis [GO:0010820]; response to lipopolysaccharide [GO:0032496]; response to reactive oxygen species [GO:0000302]	azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; RAGE receptor binding [GO:0050786]; zinc ion binding [GO:0008270]; zinc ion sequestering activity [GO:0140486]	azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; RAGE receptor binding [GO:0050786]; zinc ion binding [GO:0008270]; zinc ion sequestering activity [GO:0140486]; angiogenesis [GO:0001525]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granulocyte chemotaxis [GO:0071624]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of T cell chemotaxis [GO:0010820]; response to lipopolysaccharide [GO:0032496]; response to reactive oxygen species [GO:0000302]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8618345}. Secreted {ECO:0000269|PubMed:8618345}. Note=Secreted by a non-classical secretory pathway.
P31152	reviewed	MK04_HUMAN	Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK)	MAPK4 ERK4 PRKM4	Homo sapiens (Human)	587	FUNCTION: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). {ECO:0000250}.		cell cycle [GO:0007049]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell cycle [GO:0007049]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}.
P31153	reviewed	METK2_HUMAN	S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II)	MAT2A AMS2 MATA2	Homo sapiens (Human)	395	FUNCTION: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}.	MISCELLANEOUS: Protein expression is regulated by post-transcriptional regulation: in presence of S-adenosyl-L-methionine, METTL16 binds and methylates the first hairpin of the 3'-UTR region of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:29262316, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, METTL16 binds the 3'-UTR region of MAT2A mRNA without methylating it due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). {ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29262316, ECO:0000269|PubMed:33930289}.	cellular response to leukemia inhibitory factor [GO:1990830]; one-carbon metabolic process [GO:0006730]; protein heterooligomerization [GO:0051291]; protein hexamerization [GO:0034214]; S-adenosylmethionine biosynthetic process [GO:0006556]	cytosol [GO:0005829]; methionine adenosyltransferase complex [GO:0048269]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methionine adenosyltransferase activity [GO:0004478]; small molecule binding [GO:0036094]	cytosol [GO:0005829]; methionine adenosyltransferase complex [GO:0048269]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methionine adenosyltransferase activity [GO:0004478]; small molecule binding [GO:0036094]; cellular response to leukemia inhibitory factor [GO:1990830]; one-carbon metabolic process [GO:0006730]; protein heterooligomerization [GO:0051291]; protein hexamerization [GO:0034214]; S-adenosylmethionine biosynthetic process [GO:0006556]	
P31213	reviewed	S5A2_HUMAN	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC 1.3.1.22) (5 alpha-SR2) (SR type 2) (Steroid 5-alpha-reductase 2) (S5AR 2) (Type II 5-alpha reductase)	SRD5A2	Homo sapiens (Human)	254	FUNCTION: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. {ECO:0000269|PubMed:10898110}.		androgen biosynthetic process [GO:0006702]; androgen metabolic process [GO:0008209]; biphenyl metabolic process [GO:0018879]; bone development [GO:0060348]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; dibenzo-p-dioxin metabolic process [GO:0018894]; female genitalia development [GO:0030540]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; phthalate metabolic process [GO:0018963]; response to follicle-stimulating hormone [GO:0032354]; response to nutrient levels [GO:0031667]; response to peptide hormone [GO:0043434]; response to steroid hormone [GO:0048545]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; steroid biosynthetic process [GO:0006694]; steroid catabolic process [GO:0006706]; testosterone biosynthetic process [GO:0061370]	cell body fiber [GO:0070852]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]	3-oxo-5-alpha-steroid 4-dehydrogenase activity [GO:0003865]; 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) [GO:0047751]; amide binding [GO:0033218]; sterol 5-alpha reductase activity [GO:0009917]; testosterone dehydrogenase [NAD(P)] activity [GO:0030283]	cell body fiber [GO:0070852]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; 3-oxo-5-alpha-steroid 4-dehydrogenase activity [GO:0003865]; 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) [GO:0047751]; amide binding [GO:0033218]; sterol 5-alpha reductase activity [GO:0009917]; testosterone dehydrogenase [NAD(P)] activity [GO:0030283]; androgen biosynthetic process [GO:0006702]; androgen metabolic process [GO:0008209]; biphenyl metabolic process [GO:0018879]; bone development [GO:0060348]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; dibenzo-p-dioxin metabolic process [GO:0018894]; female genitalia development [GO:0030540]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; phthalate metabolic process [GO:0018963]; response to follicle-stimulating hormone [GO:0032354]; response to nutrient levels [GO:0031667]; response to peptide hormone [GO:0043434]; response to steroid hormone [GO:0048545]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; steroid biosynthetic process [GO:0006694]; steroid catabolic process [GO:0006706]; testosterone biosynthetic process [GO:0061370]	SUBCELLULAR LOCATION: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P31249	reviewed	HXD3_HUMAN	Homeobox protein Hox-D3 (Homeobox protein Hox-4A)	HOXD3 HOX1D HOX4A	Homo sapiens (Human)	432	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; cartilage development [GO:0051216]; cell-matrix adhesion [GO:0007160]; DNA-templated transcription [GO:0006351]; embryonic skeletal system morphogenesis [GO:0048704]; glossopharyngeal nerve morphogenesis [GO:0021615]; Notch signaling pathway [GO:0007219]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; thyroid gland development [GO:0030878]	aggresome [GO:0016235]; chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	aggresome [GO:0016235]; chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; cartilage development [GO:0051216]; cell-matrix adhesion [GO:0007160]; DNA-templated transcription [GO:0006351]; embryonic skeletal system morphogenesis [GO:0048704]; glossopharyngeal nerve morphogenesis [GO:0021615]; Notch signaling pathway [GO:0007219]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; thyroid gland development [GO:0030878]	SUBCELLULAR LOCATION: Nucleus.
P31260	reviewed	HXA10_HUMAN	Homeobox protein Hox-A10 (Homeobox protein Hox-1.8) (Homeobox protein Hox-1H) (PL)	HOXA10 HOX1H	Homo sapiens (Human)	410	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.		anterior/posterior pattern specification [GO:0009952]; embryonic limb morphogenesis [GO:0030326]; male gonad development [GO:0008584]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to testosterone [GO:0033574]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]; spermatogenesis [GO:0007283]; uterus development [GO:0060065]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; embryonic limb morphogenesis [GO:0030326]; male gonad development [GO:0008584]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to testosterone [GO:0033574]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]; spermatogenesis [GO:0007283]; uterus development [GO:0060065]	SUBCELLULAR LOCATION: Nucleus.
P31268	reviewed	HXA7_HUMAN	Homeobox protein Hox-A7 (Homeobox protein Hox 1.1) (Homeobox protein Hox-1A)	HOXA7 HOX1A	Homo sapiens (Human)	230	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]	chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Nucleus.
P31269	reviewed	HXA9_HUMAN	Homeobox protein Hox-A9 (Homeobox protein Hox-1G)	HOXA9 HOX1G	Homo sapiens (Human)	272	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed:22269951). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity). {ECO:0000250|UniProtKB:P09631, ECO:0000269|PubMed:22269951}.		anterior/posterior pattern specification [GO:0009952]; definitive hemopoiesis [GO:0060216]; DNA-templated transcription [GO:0006351]; embryonic forelimb morphogenesis [GO:0035115]; embryonic skeletal system morphogenesis [GO:0048704]; endothelial cell activation [GO:0042118]; male gonad development [GO:0008584]; mammary gland development [GO:0030879]; negative regulation of myeloid cell differentiation [GO:0045638]; prostate gland development [GO:0030850]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; uterus development [GO:0060065]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; definitive hemopoiesis [GO:0060216]; DNA-templated transcription [GO:0006351]; embryonic forelimb morphogenesis [GO:0035115]; embryonic skeletal system morphogenesis [GO:0048704]; endothelial cell activation [GO:0042118]; male gonad development [GO:0008584]; mammary gland development [GO:0030879]; negative regulation of myeloid cell differentiation [GO:0045638]; prostate gland development [GO:0030850]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; uterus development [GO:0060065]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15657436}. Cytoplasm {ECO:0000269|PubMed:15657436}.
P31270	reviewed	HXA11_HUMAN	Homeobox protein Hox-A11 (Homeobox protein Hox-1I)	HOXA11 HOX1I	Homo sapiens (Human)	313	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; branching involved in ureteric bud morphogenesis [GO:0001658]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; chondrocyte development [GO:0002063]; developmental growth [GO:0048589]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal joint morphogenesis [GO:0060272]; male gonad development [GO:0008584]; mesodermal cell fate specification [GO:0007501]; metanephros development [GO:0001656]; organ induction [GO:0001759]; positive regulation of cell development [GO:0010720]; positive regulation of chondrocyte development [GO:1902761]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; prostate gland development [GO:0030850]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to testosterone [GO:0033574]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]; spermatogenesis [GO:0007283]; uterus development [GO:0060065]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; branching involved in ureteric bud morphogenesis [GO:0001658]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; chondrocyte development [GO:0002063]; developmental growth [GO:0048589]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal joint morphogenesis [GO:0060272]; male gonad development [GO:0008584]; mesodermal cell fate specification [GO:0007501]; metanephros development [GO:0001656]; organ induction [GO:0001759]; positive regulation of cell development [GO:0010720]; positive regulation of chondrocyte development [GO:1902761]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; prostate gland development [GO:0030850]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to testosterone [GO:0033574]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]; spermatogenesis [GO:0007283]; uterus development [GO:0060065]	SUBCELLULAR LOCATION: Nucleus.
P31271	reviewed	HXA13_HUMAN	Homeobox protein Hox-A13 (Homeobox protein Hox-1J)	HOXA13 HOX1J	Homo sapiens (Human)	388	FUNCTION: Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.; FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		artery morphogenesis [GO:0048844]; branching involved in prostate gland morphogenesis [GO:0060442]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindgut morphogenesis [GO:0048619]; endothelial cell fate specification [GO:0060847]; endothelial cell morphogenesis [GO:0001886]; inner ear development [GO:0048839]; male genitalia development [GO:0030539]; mesenchymal cell apoptotic process [GO:0097152]; mitotic nuclear division [GO:0140014]; positive regulation of mesenchymal cell apoptotic process [GO:2001055]; positive regulation of mitotic nuclear division [GO:0045840]; regulation of BMP signaling pathway [GO:0030510]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; skeletal system development [GO:0001501]; tissue homeostasis [GO:0001894]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570]; ventricular septum development [GO:0003281]	chromatin [GO:0000785]; chromosome [GO:0005694]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; chromosome [GO:0005694]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; artery morphogenesis [GO:0048844]; branching involved in prostate gland morphogenesis [GO:0060442]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindgut morphogenesis [GO:0048619]; endothelial cell fate specification [GO:0060847]; endothelial cell morphogenesis [GO:0001886]; inner ear development [GO:0048839]; male genitalia development [GO:0030539]; mesenchymal cell apoptotic process [GO:0097152]; mitotic nuclear division [GO:0140014]; positive regulation of mesenchymal cell apoptotic process [GO:2001055]; positive regulation of mitotic nuclear division [GO:0045840]; regulation of BMP signaling pathway [GO:0030510]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; skeletal system development [GO:0001501]; tissue homeostasis [GO:0001894]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Nucleus.
P31273	reviewed	HXC8_HUMAN	Homeobox protein Hox-C8 (Homeobox protein Hox-3A)	HOXC8 HOX3A	Homo sapiens (Human)	242	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system morphogenesis [GO:0048705]	chromatin [GO:0000785]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system morphogenesis [GO:0048705]	SUBCELLULAR LOCATION: Nucleus.
P31274	reviewed	HXC9_HUMAN	Homeobox protein Hox-C9 (Homeobox protein Hox-3B)	HOXC9 HOX3B	Homo sapiens (Human)	260	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; DNA-templated transcription [GO:0006351]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of cell cycle [GO:0045786]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]	aggresome [GO:0016235]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	aggresome [GO:0016235]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; DNA-templated transcription [GO:0006351]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of cell cycle [GO:0045786]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P31276	reviewed	HXC13_HUMAN	Homeobox protein Hox-C13 (Homeobox protein Hox-3G)	HOXC13 HOX3G	Homo sapiens (Human)	330	FUNCTION: Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity). {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; hair follicle development [GO:0001942]; nail development [GO:0035878]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; tongue morphogenesis [GO:0043587]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; hair follicle development [GO:0001942]; nail development [GO:0035878]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; tongue morphogenesis [GO:0043587]	SUBCELLULAR LOCATION: Nucleus.
P31314	reviewed	TLX1_HUMAN	T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)	TLX1 HOX11 TCL3	Homo sapiens (Human)	330	FUNCTION: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.	MISCELLANEOUS: TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity.	animal organ development [GO:0048513]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; animal organ development [GO:0048513]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P31321	reviewed	KAP1_HUMAN	cAMP-dependent protein kinase type I-beta regulatory subunit	PRKAR1B	Homo sapiens (Human)	381	FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}.		learning or memory [GO:0007611]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of fear response [GO:1903367]; positive regulation of long-term synaptic potentiation [GO:1900273]; protein phosphorylation [GO:0006468]; regulation of synaptic vesicle cycle [GO:0098693]	cAMP-dependent protein kinase complex [GO:0005952]; ciliary base [GO:0097546]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685]	cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein kinase A catalytic subunit binding [GO:0034236]	cAMP-dependent protein kinase complex [GO:0005952]; ciliary base [GO:0097546]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685]; cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein kinase A catalytic subunit binding [GO:0034236]; learning or memory [GO:0007611]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of fear response [GO:1903367]; positive regulation of long-term synaptic potentiation [GO:1900273]; protein phosphorylation [GO:0006468]; regulation of synaptic vesicle cycle [GO:0098693]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23115245}.
P31323	reviewed	KAP3_HUMAN	cAMP-dependent protein kinase type II-beta regulatory subunit	PRKAR2B	Homo sapiens (Human)	418	FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.		fatty acid metabolic process [GO:0006631]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; response to antipsychotic drug [GO:0097332]	cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein domain specific binding [GO:0019904]; protein kinase A catalytic subunit binding [GO:0034236]; ubiquitin protein ligase binding [GO:0031625]	cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein domain specific binding [GO:0019904]; protein kinase A catalytic subunit binding [GO:0034236]; ubiquitin protein ligase binding [GO:0031625]; fatty acid metabolic process [GO:0006631]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; response to antipsychotic drug [GO:0097332]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
P31327	reviewed	CPSM_HUMAN	Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I)	CPS1	Homo sapiens (Human)	1500	FUNCTION: Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.		'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; carbamoyl phosphate biosynthetic process [GO:0070409]; cellular response to ammonium ion [GO:0071242]; cellular response to cAMP [GO:0071320]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucagon stimulus [GO:0071377]; cellular response to oleic acid [GO:0071400]; citrulline biosynthetic process [GO:0019240]; glutamine metabolic process [GO:0006541]; hepatocyte differentiation [GO:0070365]; homocysteine metabolic process [GO:0050667]; midgut development [GO:0007494]; monoatomic anion homeostasis [GO:0055081]; nitric oxide metabolic process [GO:0046209]; response to amine [GO:0014075]; response to amino acid [GO:0043200]; response to dexamethasone [GO:0071548]; response to food [GO:0032094]; response to growth hormone [GO:0060416]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; triglyceride catabolic process [GO:0019433]; urea cycle [GO:0000050]; vasodilation [GO:0042311]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; endopeptidase activity [GO:0004175]; glutamate binding [GO:0016595]; metal ion binding [GO:0046872]; modified amino acid binding [GO:0072341]; phospholipid binding [GO:0005543]; potassium ion binding [GO:0030955]; protein-containing complex binding [GO:0044877]; small molecule binding [GO:0036094]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; endopeptidase activity [GO:0004175]; glutamate binding [GO:0016595]; metal ion binding [GO:0046872]; modified amino acid binding [GO:0072341]; phospholipid binding [GO:0005543]; potassium ion binding [GO:0030955]; protein-containing complex binding [GO:0044877]; small molecule binding [GO:0036094]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; carbamoyl phosphate biosynthetic process [GO:0070409]; cellular response to ammonium ion [GO:0071242]; cellular response to cAMP [GO:0071320]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucagon stimulus [GO:0071377]; cellular response to oleic acid [GO:0071400]; citrulline biosynthetic process [GO:0019240]; glutamine metabolic process [GO:0006541]; hepatocyte differentiation [GO:0070365]; homocysteine metabolic process [GO:0050667]; midgut development [GO:0007494]; monoatomic anion homeostasis [GO:0055081]; nitric oxide metabolic process [GO:0046209]; response to amine [GO:0014075]; response to amino acid [GO:0043200]; response to dexamethasone [GO:0071548]; response to food [GO:0032094]; response to growth hormone [GO:0060416]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; triglyceride catabolic process [GO:0019433]; urea cycle [GO:0000050]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22002106}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106}. Cell membrane {ECO:0000250|UniProtKB:Q8C196}; Peripheral membrane protein {ECO:0000305}; Extracellular side {ECO:0000250|UniProtKB:Q8C196}. Note=Localizes to the cell surface of hepatocytes. {ECO:0000250|UniProtKB:Q8C196}.
P31350	reviewed	RIR2_HUMAN	Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)	RRM2 RR2	Homo sapiens (Human)	389	FUNCTION: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.	MISCELLANEOUS: Two distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic site, located on M1, is formed only in the presence of the second subunit M2.	2'-deoxyribonucleotide biosynthetic process [GO:0009265]; blastocyst development [GO:0001824]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein heterotetramerization [GO:0051290]; ribonucleoside diphosphate metabolic process [GO:0009185]	cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoside-diphosphate reductase complex [GO:0005971]	ferric iron binding [GO:0008199]; protein homodimerization activity [GO:0042803]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]	cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoside-diphosphate reductase complex [GO:0005971]; ferric iron binding [GO:0008199]; protein homodimerization activity [GO:0042803]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]; 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; blastocyst development [GO:0001824]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein heterotetramerization [GO:0051290]; ribonucleoside diphosphate metabolic process [GO:0009185]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22632967}. Nucleus {ECO:0000269|PubMed:22632967}. Note=Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells. {ECO:0000269|PubMed:22632967}.
P31358	reviewed	CD52_HUMAN	CAMPATH-1 antigen (CDw52) (Cambridge pathology 1 antigen) (Epididymal secretory protein E5) (Human epididymis-specific protein 5) (He5) (CD antigen CD52)	CD52 CDW52 HE5	Homo sapiens (Human)	61	FUNCTION: May play a role in carrying and orienting carbohydrate, as well as having a more specific role.		positive regulation of cytosolic calcium ion concentration [GO:0007204]; respiratory burst [GO:0045730]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; sperm midpiece [GO:0097225]		extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; sperm midpiece [GO:0097225]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; respiratory burst [GO:0045730]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
P31371	reviewed	FGF9_HUMAN	Fibroblast growth factor 9 (FGF-9) (Glia-activating factor) (GAF) (Heparin-binding growth factor 9) (HBGF-9)	FGF9	Homo sapiens (Human)	208	FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:8663044}.	MISCELLANEOUS: Biochemical analysis of the Asn-99 mutation reveals a significantly impaired FGF signaling, as evidenced by diminished activity of the MAPK1/MAPK2 pathway and decreases CTNNB1 and MYC expression when compared with wild-type protein. Binding of mutant protein to the receptor FGFR3 is severely impaired, although homodimerization of mutant to itself or wild-type is not detectably affected, providing a basis for the observed defective FGF9 signaling.	activin receptor signaling pathway [GO:0032924]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle cell proliferation [GO:0060038]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; chondrocyte differentiation [GO:0002062]; embryonic digestive tract development [GO:0048566]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system development [GO:0048706]; eye development [GO:0001654]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inner ear morphogenesis [GO:0042472]; lung development [GO:0030324]; lung-associated mesenchyme development [GO:0060484]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; mesenchymal cell proliferation [GO:0010463]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [GO:1905931]; negative regulation of Wnt signaling pathway [GO:0030178]; osteoblast differentiation [GO:0001649]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reproductive process [GO:2000243]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein import into nucleus [GO:0006606]; regulation of cell migration [GO:0030334]; regulation of timing of cell differentiation [GO:0048505]; Sertoli cell proliferation [GO:0060011]; signal transduction [GO:0007165]; smoothened signaling pathway [GO:0007224]; stem cell proliferation [GO:0072089]; substantia nigra development [GO:0021762]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; activin receptor signaling pathway [GO:0032924]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle cell proliferation [GO:0060038]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; chondrocyte differentiation [GO:0002062]; embryonic digestive tract development [GO:0048566]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system development [GO:0048706]; eye development [GO:0001654]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inner ear morphogenesis [GO:0042472]; lung development [GO:0030324]; lung-associated mesenchyme development [GO:0060484]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; mesenchymal cell proliferation [GO:0010463]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [GO:1905931]; negative regulation of Wnt signaling pathway [GO:0030178]; osteoblast differentiation [GO:0001649]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reproductive process [GO:2000243]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein import into nucleus [GO:0006606]; regulation of cell migration [GO:0030334]; regulation of timing of cell differentiation [GO:0048505]; Sertoli cell proliferation [GO:0060011]; signal transduction [GO:0007165]; smoothened signaling pathway [GO:0007224]; stem cell proliferation [GO:0072089]; substantia nigra development [GO:0021762]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Secreted.
P31391	reviewed	SSR4_HUMAN	Somatostatin receptor type 4 (SS-4-R) (SS4-R) (SS4R) (SST4)	SSTR4	Homo sapiens (Human)	388	FUNCTION: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.		cell migration [GO:0016477]; cellular response to glucocorticoid stimulus [GO:0071385]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]	neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994]; cell migration [GO:0016477]; cellular response to glucocorticoid stimulus [GO:0071385]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P31415	reviewed	CASQ1_HUMAN	Calsequestrin-1 (Calmitine) (Calsequestrin, skeletal muscle isoform)	CASQ1 CASQ	Homo sapiens (Human)	396	FUNCTION: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:28895244). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions (PubMed:28895244). Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (PubMed:27185316). {ECO:0000269|PubMed:22337878, ECO:0000269|PubMed:27185316, ECO:0000269|PubMed:28895244, ECO:0000303|PubMed:22337878}.		endoplasmic reticulum organization [GO:0007029]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of store-operated calcium channel activity [GO:1901341]; protein polymerization [GO:0051258]; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809]; regulation of store-operated calcium entry [GO:2001256]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to heat [GO:0009408]; response to organic substance [GO:0010033]; sarcomere organization [GO:0045214]; skeletal muscle tissue development [GO:0007519]	endoplasmic reticulum [GO:0005783]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; T-tubule [GO:0030315]; terminal cisterna lumen [GO:0014804]; Z disc [GO:0030018]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]	endoplasmic reticulum [GO:0005783]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; T-tubule [GO:0030315]; terminal cisterna lumen [GO:0014804]; Z disc [GO:0030018]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; endoplasmic reticulum organization [GO:0007029]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of store-operated calcium channel activity [GO:1901341]; protein polymerization [GO:0051258]; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809]; regulation of store-operated calcium entry [GO:2001256]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to heat [GO:0009408]; response to organic substance [GO:0010033]; sarcomere organization [GO:0045214]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:27185316, ECO:0000269|PubMed:28895244}. Sarcoplasmic reticulum {ECO:0000269|PubMed:27196359}. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P07221}. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side {ECO:0000250|UniProtKB:P07221}. Mitochondrion matrix {ECO:0000250|UniProtKB:O09165}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells (PubMed:28895244). In a minority of cells, homogeneously detected in the ER lumen (PubMed:28895244). Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316). {ECO:0000250|UniProtKB:P07221, ECO:0000269|PubMed:27185316, ECO:0000269|PubMed:28895244}.
P31431	reviewed	SDC4_HUMAN	Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein)	SDC4	Homo sapiens (Human)	198	FUNCTION: Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). {ECO:0000269|PubMed:22660413}.	MISCELLANEOUS: [Isoform 2]: Soluble form, lacks the transmembrane domain. {ECO:0000305}.	cell migration [GO:0016477]; inner ear receptor cell stereocilium organization [GO:0060122]; negative regulation of T cell proliferation [GO:0042130]; neural tube closure [GO:0001843]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of stress fiber assembly [GO:0051496]; regulation of fibroblast migration [GO:0010762]; ureteric bud development [GO:0001657]; wound healing [GO:0042060]	cell surface [GO:0009986]; costamere [GO:0043034]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]	fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; protein kinase C binding [GO:0005080]; thrombospondin receptor activity [GO:0070053]	cell surface [GO:0009986]; costamere [GO:0043034]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; protein kinase C binding [GO:0005080]; thrombospondin receptor activity [GO:0070053]; cell migration [GO:0016477]; inner ear receptor cell stereocilium organization [GO:0060122]; negative regulation of T cell proliferation [GO:0042130]; neural tube closure [GO:0001843]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of stress fiber assembly [GO:0051496]; regulation of fibroblast migration [GO:0010762]; ureteric bud development [GO:0001657]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:9169435}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000269|PubMed:9169435}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
P31483	reviewed	TIA1_HUMAN	Cytotoxic granule associated RNA binding protein TIA1 (Nucleolysin TIA-1 isoform p40) (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1)	TIA1	Homo sapiens (Human)	386	FUNCTION: RNA-binding protein involved in the regulation of alternative pre-RNA splicing and mRNA translation by binding to uridine-rich (U-rich) RNA sequences (PubMed:8576255, PubMed:11106748, PubMed:12486009, PubMed:17488725). Binds to U-rich sequences immediately downstream from a 5' splice sites in a uridine-rich small nuclear ribonucleoprotein (U snRNP)-dependent fashion, thereby modulating alternative pre-RNA splicing (PubMed:11106748, PubMed:8576255). Preferably binds to the U-rich IAS1 sequence in a U1 snRNP-dependent manner; this binding is optimal if a 5' splice site is adjacent to IAS1 (By similarity). Activates the use of heterologous 5' splice sites; the activation depends on the intron sequence downstream from the 5' splice site, with a preference for a downstream U-rich sequence (PubMed:11106748). By interacting with SNRPC/U1-C, promotes recruitment and binding of spliceosomal U1 snRNP to 5' splice sites followed by U-rich sequences, thereby facilitating atypical 5' splice site recognition by U1 snRNP (PubMed:11106748, PubMed:12486009, PubMed:17488725). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIAR mRNA (By similarity). Acts as a modulator of alternative splicing for the apoptotic FAS receptor, thereby promoting apoptosis (PubMed:11106748, PubMed:1934064, PubMed:17488725). Binds to the 5' splice site region of FAS intron 5 to promote accumulation of transcripts that include exon 6 at the expense of transcripts in which exon 6 is skipped, thereby leading to the transcription of a membrane-bound apoptotic FAS receptor, which promotes apoptosis (PubMed:11106748, PubMed:1934064, PubMed:17488725). Binds to a conserved AU-rich cis element in COL2A1 intron 2 and modulates alternative splicing of COL2A1 exon 2 (PubMed:17580305). Also binds to the equivalent AT-rich element in COL2A1 genomic DNA, and may thereby be involved in the regulation of transcription (PubMed:17580305). Binds specifically to a polypyrimidine-rich controlling element (PCE) located between the weak 5' splice site and the intronic splicing silencer of CFTR mRNA to promote exon 9 inclusion, thereby antagonizing PTB1 and its role in exon skipping of CFTR exon 9 (PubMed:14966131). Involved in the repression of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs), including target ARE-bearing mRNAs encoding TNF and PTGS2 (By similarity). Also participates in the cellular response to environmental stress, by acting downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SGs), leading to stress-induced translational arrest (PubMed:10613902). Formation and recruitment to SGs is regulated by Zn(2+) (By similarity). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1934064). {ECO:0000250|UniProtKB:P52912, ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:11106748, ECO:0000269|PubMed:12486009, ECO:0000269|PubMed:14966131, ECO:0000269|PubMed:17488725, ECO:0000269|PubMed:17580305, ECO:0000269|PubMed:1934064, ECO:0000269|PubMed:8576255}.; FUNCTION: [Isoform Short]: Displays enhanced splicing regulatory activity compared with TIA isoform Long. {ECO:0000269|PubMed:17488725}.		apoptotic process [GO:0006915]; mRNA processing [GO:0006397]; negative regulation of cytokine production [GO:0001818]; negative regulation of translation [GO:0017148]; positive regulation of epithelial cell apoptotic process [GO:1904037]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; stress granule assembly [GO:0034063]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; mRNA processing [GO:0006397]; negative regulation of cytokine production [GO:0001818]; negative regulation of translation [GO:0017148]; positive regulation of epithelial cell apoptotic process [GO:1904037]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:15371533, ECO:0000269|PubMed:17984221, ECO:0000305|PubMed:18201561}. Cytoplasm {ECO:0000269|PubMed:17488725}. Cytoplasm, Stress granule {ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:15371533, ECO:0000269|PubMed:17984221}. Note=Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:15371533, PubMed:10613902). Recruitment to SG is induced by Zn(2+) (By similarity). {ECO:0000250|UniProtKB:P52912, ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:15371533}.
P31512	reviewed	FMO4_HUMAN	Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Dimethylaniline oxidase 4) (Hepatic flavin-containing monooxygenase 4) (FMO 4)	FMO4 FMO2	Homo sapiens (Human)	558	FUNCTION: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.		energy homeostasis [GO:0097009]; negative regulation of fatty acid oxidation [GO:0046322]; xenobiotic catabolic process [GO:0042178]	endoplasmic reticulum membrane [GO:0005789]	flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	endoplasmic reticulum membrane [GO:0005789]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; energy homeostasis [GO:0097009]; negative regulation of fatty acid oxidation [GO:0046322]; xenobiotic catabolic process [GO:0042178]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:Q8K4B7}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8K4B7}; Single-pass membrane protein {ECO:0000255}.
P31513	reviewed	FMO3_HUMAN	Flavin-containing monooxygenase 3 (EC 1.14.13.148) (EC 1.14.13.32) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 3) (Dimethylaniline oxidase 3) (FMO II) (FMO form 2) (Hepatic flavin-containing monooxygenase 3) (FMO 3) (Trimethylamine monooxygenase)	FMO3	Homo sapiens (Human)	532	FUNCTION: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441, PubMed:32156684). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269). {ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:29981269, ECO:0000269|PubMed:30381441, ECO:0000269|PubMed:32156684, ECO:0000269|PubMed:9224773, ECO:0000269|PubMed:9776311}.		taurine biosynthetic process [GO:0042412]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	albendazole monooxygenase activity [GO:0047638]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; albendazole monooxygenase activity [GO:0047638]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]; taurine biosynthetic process [GO:0042412]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:P32417}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32417}; Single-pass membrane protein {ECO:0000255}.
P31629	reviewed	ZEP2_HUMAN	Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2)	HIVEP2	Homo sapiens (Human)	2446	FUNCTION: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P31639	reviewed	SC5A2_HUMAN	Sodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2)	SLC5A2 SGLT2	Homo sapiens (Human)	672	FUNCTION: Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity). {ECO:0000250|UniProtKB:Q923I7, ECO:0000269|PubMed:20980548, ECO:0000269|PubMed:28592437, ECO:0000269|PubMed:34880493}.		alpha-glucoside transport [GO:0000017]; carbohydrate metabolic process [GO:0005975]; glucose import across plasma membrane [GO:0098708]; hexose transmembrane transport [GO:0008645]; renal glucose absorption [GO:0035623]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transport [GO:0006814]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	alpha-glucoside transmembrane transporter activity [GO:0015151]; D-glucose transmembrane transporter activity [GO:0055056]; glucose:sodium symporter activity [GO:0005412]; low-affinity glucose:sodium symporter activity [GO:0005362]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; alpha-glucoside transmembrane transporter activity [GO:0015151]; D-glucose transmembrane transporter activity [GO:0055056]; glucose:sodium symporter activity [GO:0005412]; low-affinity glucose:sodium symporter activity [GO:0005362]; alpha-glucoside transport [GO:0000017]; carbohydrate metabolic process [GO:0005975]; glucose import across plasma membrane [GO:0098708]; hexose transmembrane transport [GO:0008645]; renal glucose absorption [GO:0035623]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q923I7}; Multi-pass membrane protein {ECO:0000255}.
P31641	reviewed	SC6A6_HUMAN	Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6)	SLC6A6	Homo sapiens (Human)	620	FUNCTION: Mediates sodium- and chloride-dependent transport of taurine (PubMed:8382624, PubMed:8010975, PubMed:8654117, PubMed:31345061, PubMed:31903486). Mediates transport of beta-alanine (PubMed:8010975). Can also mediate transport of hypotaurine and gamma-aminobutyric acid (GABA) (By similarity). {ECO:0000250|UniProtKB:O35316, ECO:0000269|PubMed:31345061, ECO:0000269|PubMed:31903486, ECO:0000269|PubMed:8010975, ECO:0000269|PubMed:8382624, ECO:0000269|PubMed:8654117}.; FUNCTION: Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake. {ECO:0000269|PubMed:31345061, ECO:0000269|PubMed:31903486, ECO:0000269|PubMed:8382624}.		alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; gamma-aminobutyric acid import [GO:0051939]; import across plasma membrane [GO:0098739]; modulation of chemical synaptic transmission [GO:0050804]; neurotransmitter transport [GO:0006836]; nitrogen compound transport [GO:0071705]; positive regulation of cell differentiation [GO:0045597]; sodium ion transmembrane transport [GO:0035725]; taurine transport [GO:0015734]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; postsynaptic membrane [GO:0045211]	alanine transmembrane transporter activity [GO:0022858]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; postsynaptic membrane [GO:0045211]; alanine transmembrane transporter activity [GO:0022858]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369]; alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; gamma-aminobutyric acid import [GO:0051939]; import across plasma membrane [GO:0098739]; modulation of chemical synaptic transmission [GO:0050804]; neurotransmitter transport [GO:0006836]; nitrogen compound transport [GO:0071705]; positive regulation of cell differentiation [GO:0045597]; sodium ion transmembrane transport [GO:0035725]; taurine transport [GO:0015734]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31345061, ECO:0000269|PubMed:31903486}; Multi-pass membrane protein {ECO:0000255}.
P31644	reviewed	GBRA5_HUMAN	Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5)	GABRA5	Homo sapiens (Human)	462	FUNCTION: Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:29961870, PubMed:31056671). May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse (PubMed:31056671). {ECO:0000269|PubMed:29961870, ECO:0000269|PubMed:31056671}.		associative learning [GO:0008306]; behavioral fear response [GO:0001662]; chloride transmembrane transport [GO:1902476]; cochlea development [GO:0090102]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384]; regulation of postsynaptic membrane potential [GO:0060078]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]	chloride channel complex [GO:0034707]; cytosol [GO:0005829]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]	GABA receptor binding [GO:0050811]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; signaling receptor activity [GO:0038023]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	chloride channel complex [GO:0034707]; cytosol [GO:0005829]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; GABA receptor binding [GO:0050811]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; signaling receptor activity [GO:0038023]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; associative learning [GO:0008306]; behavioral fear response [GO:0001662]; chloride transmembrane transport [GO:1902476]; cochlea development [GO:0090102]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384]; regulation of postsynaptic membrane potential [GO:0060078]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:31056671}; Multi-pass membrane protein. Cell membrane {ECO:0000269|PubMed:31056671}; Multi-pass membrane protein.
P31645	reviewed	SC6A4_HUMAN	Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4)	SLC6A4 HTT SERT	Homo sapiens (Human)	630	FUNCTION: Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:27756841, PubMed:34851672, PubMed:21730057, PubMed:10407194, PubMed:27049939, PubMed:12869649). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:27756841, PubMed:34851672, PubMed:21730057, PubMed:10407194, PubMed:27049939, PubMed:12869649). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}.	MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.	brain morphogenesis [GO:0048854]; cellular response to cGMP [GO:0071321]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; enteric nervous system development [GO:0048484]; membrane depolarization [GO:0051899]; memory [GO:0007613]; monoamine transport [GO:0015844]; negative regulation of cerebellar granule cell precursor proliferation [GO:0021941]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of organ growth [GO:0046621]; negative regulation of synaptic transmission, dopaminergic [GO:0032227]; neurotransmitter transport [GO:0006836]; platelet aggregation [GO:0070527]; positive regulation of cell cycle [GO:0045787]; positive regulation of gene expression [GO:0010628]; positive regulation of serotonin secretion [GO:0014064]; regulation of thalamus size [GO:0090067]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; serotonin uptake [GO:0051610]; social behavior [GO:0035176]; sodium ion transmembrane transport [GO:0035725]; sperm ejaculation [GO:0042713]; vasoconstriction [GO:0042310]	endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; serotonergic synapse [GO:0099154]; synapse [GO:0045202]	actin filament binding [GO:0051015]; antiporter activity [GO:0015297]; cocaine binding [GO:0019811]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; monoamine transmembrane transporter activity [GO:0008504]; monoatomic cation channel activity [GO:0005261]; neurotransmitter transmembrane transporter activity [GO:0005326]; nitric-oxide synthase binding [GO:0050998]; serotonin binding [GO:0051378]; serotonin:sodium:chloride symporter activity [GO:0005335]; sodium ion binding [GO:0031402]; syntaxin-1 binding [GO:0017075]	endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; serotonergic synapse [GO:0099154]; synapse [GO:0045202]; actin filament binding [GO:0051015]; antiporter activity [GO:0015297]; cocaine binding [GO:0019811]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; monoamine transmembrane transporter activity [GO:0008504]; monoatomic cation channel activity [GO:0005261]; neurotransmitter transmembrane transporter activity [GO:0005326]; nitric-oxide synthase binding [GO:0050998]; serotonin binding [GO:0051378]; serotonin:sodium:chloride symporter activity [GO:0005335]; sodium ion binding [GO:0031402]; syntaxin-1 binding [GO:0017075]; brain morphogenesis [GO:0048854]; cellular response to cGMP [GO:0071321]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; enteric nervous system development [GO:0048484]; membrane depolarization [GO:0051899]; memory [GO:0007613]; monoamine transport [GO:0015844]; negative regulation of cerebellar granule cell precursor proliferation [GO:0021941]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of organ growth [GO:0046621]; negative regulation of synaptic transmission, dopaminergic [GO:0032227]; neurotransmitter transport [GO:0006836]; platelet aggregation [GO:0070527]; positive regulation of cell cycle [GO:0045787]; positive regulation of gene expression [GO:0010628]; positive regulation of serotonin secretion [GO:0014064]; regulation of thalamus size [GO:0090067]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; serotonin uptake [GO:0051610]; social behavior [GO:0035176]; sodium ion transmembrane transport [GO:0035725]; sperm ejaculation [GO:0042713]; vasoconstriction [GO:0042310]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:16870614, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:27049939}; Multi-pass membrane protein {ECO:0000269|PubMed:27049939}. Endomembrane system {ECO:0000269|PubMed:16870614}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:16870614}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q60857}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q60857}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q60857}. Note=Could be part of recycling endosomes (PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:16870614, ECO:0000269|PubMed:17506858}.
P31689	reviewed	DNJA1_HUMAN	DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)	DNAJA1 DNAJ2 HDJ2 HSJ2 HSPF4	Homo sapiens (Human)	397	FUNCTION: Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}.		androgen receptor signaling pathway [GO:0030521]; flagellated sperm motility [GO:0030317]; negative regulation of apoptotic process [GO:0043066]; negative regulation of establishment of protein localization to mitochondrion [GO:1903748]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway [GO:1905259]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of apoptotic process [GO:0043065]; protein folding [GO:0006457]; protein localization to mitochondrion [GO:0070585]; protein refolding [GO:0042026]; regulation of protein transport [GO:0051223]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; ATPase activator activity [GO:0001671]; C3HC4-type RING finger domain binding [GO:0055131]; G protein-coupled receptor binding [GO:0001664]; Hsp70 protein binding [GO:0030544]; low-density lipoprotein particle receptor binding [GO:0050750]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; Tat protein binding [GO:0030957]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; ATPase activator activity [GO:0001671]; C3HC4-type RING finger domain binding [GO:0055131]; G protein-coupled receptor binding [GO:0001664]; Hsp70 protein binding [GO:0030544]; low-density lipoprotein particle receptor binding [GO:0050750]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; Tat protein binding [GO:0030957]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; androgen receptor signaling pathway [GO:0030521]; flagellated sperm motility [GO:0030317]; negative regulation of apoptotic process [GO:0043066]; negative regulation of establishment of protein localization to mitochondrion [GO:1903748]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway [GO:1905259]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of apoptotic process [GO:0043065]; protein folding [GO:0006457]; protein localization to mitochondrion [GO:0070585]; protein refolding [GO:0042026]; regulation of protein transport [GO:0051223]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:10816573}; Lipid-anchor {ECO:0000305|PubMed:10816573}. Cytoplasm {ECO:0000269|PubMed:10816573}. Microsome {ECO:0000250}. Nucleus {ECO:0000269|PubMed:10816573}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10816573}. Mitochondrion {ECO:0000250}. Note=Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei. {ECO:0000250}.
P31749	reviewed	AKT1_HUMAN	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)	AKT1 PKB RAC	Homo sapiens (Human)	480	FUNCTION: AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:15861136, PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781, PubMed:31204173). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781, PubMed:31204173). Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (By similarity). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (PubMed:11994271). AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (By similarity). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase) (PubMed:11154276). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis (PubMed:11154276). AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating the mTORC1 signaling pathway, and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1 (PubMed:12150915, PubMed:12172553). Also regulates the mTORC1 signaling pathway by catalyzing phosphorylation of CASTOR1 and DEPDC5 (PubMed:31548394, PubMed:33594058). AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization (PubMed:10358075). In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319' (PubMed:10358075). FOXO3 and FOXO4 are phosphorylated on equivalent sites (PubMed:10358075). AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein) (PubMed:9829964). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (PubMed:9829964). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) (PubMed:12176338, PubMed:12964941). AKT mediates the antiapoptotic effects of IGF-I (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3 (PubMed:17726016). Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation (PubMed:20086174, PubMed:20231902). Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation (PubMed:19592491). Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity (PubMed:10576742). Phosphorylation of BAD stimulates its pro-apoptotic activity (PubMed:10926925). Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53 (PubMed:23431171). Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility (PubMed:20471940). Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation (PubMed:18507042). Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization (PubMed:16982699). These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation (PubMed:16139227). Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (PubMed:20682768). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (PubMed:32322062). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (PubMed:32228865). Acts as an inhibitor of tRNA methylation by mediating phosphorylation of the N-terminus of METTL1, thereby inhibiting METTL1 methyltransferase activity (PubMed:15861136). In response to LPAR1 receptor pathway activation, phosphorylates Rabin8/RAB3IP which alters its activity and phosphorylates WDR44 which induces WDR44 binding to Rab11, thereby switching Rab11 vesicular function from preciliary trafficking to endocytic recycling (PubMed:31204173). {ECO:0000250|UniProtKB:P31750, ECO:0000250|UniProtKB:P47196, ECO:0000269|PubMed:10358075, ECO:0000269|PubMed:10576742, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11994271, ECO:0000269|PubMed:12150915, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12176338, ECO:0000269|PubMed:12964941, ECO:0000269|PubMed:15861136, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:17726016, ECO:0000269|PubMed:18507042, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20231902, ECO:0000269|PubMed:20471940, ECO:0000269|PubMed:20682768, ECO:0000269|PubMed:23431171, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:32228865, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:33594058, ECO:0000269|PubMed:9829964, ECO:0000303|PubMed:11882383, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}.		activation-induced cell death of T cells [GO:0006924]; anoikis [GO:0043276]; apoptotic mitochondrial changes [GO:0008637]; behavioral response to pain [GO:0048266]; canonical NF-kappaB signal transduction [GO:0007249]; carbohydrate transport [GO:0008643]; cell differentiation [GO:0030154]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell population proliferation [GO:0008283]; cellular response to cadmium ion [GO:0071276]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to insulin stimulus [GO:0032869]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of protein localization to mitochondrion [GO:0072655]; excitatory postsynaptic potential [GO:0060079]; execution phase of apoptosis [GO:0097194]; fibroblast migration [GO:0010761]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen cell differentiation involved in embryonic placenta development [GO:0060709]; inflammatory response [GO:0006954]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-18-mediated signaling pathway [GO:0035655]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; maintenance of protein location in mitochondrion [GO:0072656]; mammalian oogenesis stage [GO:0022605]; mammary gland epithelial cell differentiation [GO:0060644]; maternal placenta development [GO:0001893]; mitigation of host antiviral defense response [GO:0019049]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cilium assembly [GO:1902018]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of gene expression [GO:0010629]; negative regulation of innate immune response [GO:0045824]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of macroautophagy [GO:0016242]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein binding [GO:0032091]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein localization to lysosome [GO:0150033]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of proteolysis [GO:0045861]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; nitric oxide biosynthetic process [GO:0006809]; non-canonical NF-kappaB signal transduction [GO:0038061]; osteoblast differentiation [GO:0001649]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peripheral nervous system myelin maintenance [GO:0032287]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of organ growth [GO:0046622]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of mRNA stability [GO:0043488]; regulation of myelination [GO:0031641]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of translation [GO:0006417]; regulation of tRNA methylation [GO:0110002]; regulation of type B pancreatic cell development [GO:2000074]; response to fluid shear stress [GO:0034405]; response to food [GO:0032094]; response to growth factor [GO:0070848]; response to growth hormone [GO:0060416]; response to heat [GO:0009408]; response to insulin-like growth factor stimulus [GO:1990418]; response to oxidative stress [GO:0006979]; response to UV-A [GO:0070141]; signal transduction [GO:0007165]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; striated muscle cell differentiation [GO:0051146]; T cell costimulation [GO:0031295]; TOR signaling [GO:0031929]	cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; vesicle [GO:0031982]	14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; nitric-oxide synthase regulator activity [GO:0030235]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; potassium channel activator activity [GO:0099104]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein serine/threonine/tyrosine kinase activity [GO:0004712]	cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; vesicle [GO:0031982]; 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; nitric-oxide synthase regulator activity [GO:0030235]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; potassium channel activator activity [GO:0099104]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; activation-induced cell death of T cells [GO:0006924]; anoikis [GO:0043276]; apoptotic mitochondrial changes [GO:0008637]; behavioral response to pain [GO:0048266]; canonical NF-kappaB signal transduction [GO:0007249]; carbohydrate transport [GO:0008643]; cell differentiation [GO:0030154]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell population proliferation [GO:0008283]; cellular response to cadmium ion [GO:0071276]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to insulin stimulus [GO:0032869]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of protein localization to mitochondrion [GO:0072655]; excitatory postsynaptic potential [GO:0060079]; execution phase of apoptosis [GO:0097194]; fibroblast migration [GO:0010761]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen cell differentiation involved in embryonic placenta development [GO:0060709]; inflammatory response [GO:0006954]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-18-mediated signaling pathway [GO:0035655]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; maintenance of protein location in mitochondrion [GO:0072656]; mammalian oogenesis stage [GO:0022605]; mammary gland epithelial cell differentiation [GO:0060644]; maternal placenta development [GO:0001893]; mitigation of host antiviral defense response [GO:0019049]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cilium assembly [GO:1902018]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of gene expression [GO:0010629]; negative regulation of innate immune response [GO:0045824]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of macroautophagy [GO:0016242]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein binding [GO:0032091]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein localization to lysosome [GO:0150033]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of proteolysis [GO:0045861]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; nitric oxide biosynthetic process [GO:0006809]; non-canonical NF-kappaB signal transduction [GO:0038061]; osteoblast differentiation [GO:0001649]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peripheral nervous system myelin maintenance [GO:0032287]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of organ growth [GO:0046622]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of mRNA stability [GO:0043488]; regulation of myelination [GO:0031641]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of translation [GO:0006417]; regulation of tRNA methylation [GO:0110002]; regulation of type B pancreatic cell development [GO:2000074]; response to fluid shear stress [GO:0034405]; response to food [GO:0032094]; response to growth factor [GO:0070848]; response to growth hormone [GO:0060416]; response to heat [GO:0009408]; response to insulin-like growth factor stimulus [GO:1990418]; response to oxidative stress [GO:0006979]; response to UV-A [GO:0070141]; signal transduction [GO:0007165]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; striated muscle cell differentiation [GO:0051146]; T cell costimulation [GO:0031295]; TOR signaling [GO:0031929]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P31750}. Nucleus {ECO:0000269|PubMed:20333297}. Cell membrane {ECO:0000269|PubMed:20333297}. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). {ECO:0000269|PubMed:16792529}.
P31751	reviewed	AKT2_HUMAN	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC-PK-beta)	AKT2	Homo sapiens (Human)	481	FUNCTION: AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Involved in the inhibition of ciliogenesis associated with RAB8-dependent cilia growth (PubMed:31204173). {ECO:0000269|PubMed:31204173}.; FUNCTION: One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on 'Ser-197' during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Phosphorylates CLK2 on 'Thr-343'.		carbohydrate transport [GO:0008643]; cellular response to high light intensity [GO:0071486]; cellular response to insulin stimulus [GO:0032869]; fat cell differentiation [GO:0045444]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; insulin receptor signaling pathway [GO:0008286]; intracellular protein transmembrane transport [GO:0065002]; intracellular signal transduction [GO:0035556]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of apoptotic process [GO:0043066]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; peripheral nervous system myelin maintenance [GO:0032287]; phosphorylation [GO:0016310]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucose import [GO:0046326]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of vesicle fusion [GO:0031340]; protein localization to plasma membrane [GO:0072659]; protein modification process [GO:0036211]; regulation of cell cycle [GO:0051726]; regulation of cell migration [GO:0030334]; regulation of translation [GO:0006417]; retinal rod cell apoptotic process [GO:0097473]; signal transduction [GO:0007165]	cell cortex [GO:0005938]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell cortex [GO:0005938]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; carbohydrate transport [GO:0008643]; cellular response to high light intensity [GO:0071486]; cellular response to insulin stimulus [GO:0032869]; fat cell differentiation [GO:0045444]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; insulin receptor signaling pathway [GO:0008286]; intracellular protein transmembrane transport [GO:0065002]; intracellular signal transduction [GO:0035556]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of apoptotic process [GO:0043066]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; peripheral nervous system myelin maintenance [GO:0032287]; phosphorylation [GO:0016310]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucose import [GO:0046326]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of vesicle fusion [GO:0031340]; protein localization to plasma membrane [GO:0072659]; protein modification process [GO:0036211]; regulation of cell cycle [GO:0051726]; regulation of cell migration [GO:0030334]; regulation of translation [GO:0006417]; retinal rod cell apoptotic process [GO:0097473]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Early endosome {ECO:0000250|UniProtKB:Q60823}. Note=Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. Colocalizes with WDFY2 in early endosomes (By similarity). {ECO:0000250|UniProtKB:Q60823}.
P31785	reviewed	IL2RG_HUMAN	Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)	IL2RG	Homo sapiens (Human)	369	FUNCTION: Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). {ECO:0000269|PubMed:15123770}.		CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; immune response [GO:0006955]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; mature B cell differentiation [GO:0002335]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell differentiation in thymus [GO:0033089]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]	cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-15 receptor activity [GO:0042010]; interleukin-2 binding [GO:0019976]	cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-15 receptor activity [GO:0042010]; interleukin-2 binding [GO:0019976]; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; immune response [GO:0006955]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; mature B cell differentiation [GO:0002335]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell differentiation in thymus [GO:0033089]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15123770}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000269|PubMed:15123770}.
P31930	reviewed	QCR1_HUMAN	Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)	UQCRC1	Homo sapiens (Human)	480	FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (PubMed:33141179). {ECO:0000250|UniProtKB:P07256, ECO:0000250|UniProtKB:P31800, ECO:0000269|PubMed:33141179, ECO:0000305|PubMed:29243944}.		aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]; response to activity [GO:0014823]; response to alkaloid [GO:0043279]	mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]	metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; ubiquitin protein ligase binding [GO:0031625]	mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; ubiquitin protein ligase binding [GO:0031625]; aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]; response to activity [GO:0014823]; response to alkaloid [GO:0043279]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07256}; Peripheral membrane protein {ECO:0000250|UniProtKB:P07256}; Matrix side {ECO:0000250|UniProtKB:P07256}.
P31937	reviewed	3HIDH_HUMAN	3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31)	HIBADH	Homo sapiens (Human)	336			valine catabolic process [GO:0006574]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	3-hydroxyisobutyrate dehydrogenase activity [GO:0008442]; NAD binding [GO:0051287]; NADP binding [GO:0050661]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 3-hydroxyisobutyrate dehydrogenase activity [GO:0008442]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; valine catabolic process [GO:0006574]	SUBCELLULAR LOCATION: Mitochondrion.
P31939	reviewed	PUR9_HUMAN	Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)]	ATIC PURH OK/SW-cl.86	Homo sapiens (Human)	592	FUNCTION: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:9378707, PubMed:11948179, PubMed:10985775). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to IMP (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}.	MISCELLANEOUS: The de novo purine synthesis pathway includes 10 sequential steps, beginning with phosphoribosyl pyrophosphate and ending with inositol monophosphate (IMP), the first purin compound of the pathway. {ECO:0000303|PubMed:11948179}.	'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; animal organ regeneration [GO:0031100]; brainstem development [GO:0003360]; cellular response to interleukin-7 [GO:0098761]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; dihydrofolate metabolic process [GO:0046452]; GMP biosynthetic process [GO:0006177]; nucleobase-containing compound metabolic process [GO:0006139]; response to inorganic substance [GO:0010035]; tetrahydrofolate biosynthetic process [GO:0046654]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; IMP cyclohydrolase activity [GO:0003937]; phosphoribosylaminoimidazolecarboxamide formyltransferase activity [GO:0004643]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; IMP cyclohydrolase activity [GO:0003937]; phosphoribosylaminoimidazolecarboxamide formyltransferase activity [GO:0004643]; protein homodimerization activity [GO:0042803]; 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; animal organ regeneration [GO:0031100]; brainstem development [GO:0003360]; cellular response to interleukin-7 [GO:0098761]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; dihydrofolate metabolic process [GO:0046452]; GMP biosynthetic process [GO:0006177]; nucleobase-containing compound metabolic process [GO:0006139]; response to inorganic substance [GO:0010035]; tetrahydrofolate biosynthetic process [GO:0046654]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54113}.
P31941	reviewed	ABC3A_HUMAN	DNA dC->dU-editing enzyme APOBEC-3A (A3A) (EC 3.5.4.38) (Phorbolin-1)	APOBEC3A	Homo sapiens (Human)	199	FUNCTION: DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:10469298, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19461882, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20615867, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21368204, ECO:0000269|PubMed:21460793, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:22457529, ECO:0000269|PubMed:22896697}.	MISCELLANEOUS: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.; MISCELLANEOUS: [Isoform 1]: Enzymatically active.; MISCELLANEOUS: [Isoform 2]: Enzymatically active. {ECO:0000305}.	clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of viral genome replication [GO:0045071]; retrotransposon silencing [GO:0010526]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]	cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of viral genome replication [GO:0045071]; retrotransposon silencing [GO:0010526]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
P31942	reviewed	HNRH3_HUMAN	Heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) (Heterogeneous nuclear ribonucleoprotein 2H9) (hnRNP 2H9)	HNRNPH3 HNRPH3	Homo sapiens (Human)	346	FUNCTION: Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.		epithelial cell differentiation [GO:0030855]; mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; epithelial cell differentiation [GO:0030855]; mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8999868}.
P31943	reviewed	HNRH1_HUMAN	Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]	HNRNPH1 HNRPH HNRPH1	Homo sapiens (Human)	449	FUNCTION: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.		mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	identical protein binding [GO:0042802]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; identical protein binding [GO:0042802]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm.
P31944	reviewed	CASPE_HUMAN	Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]	CASP14	Homo sapiens (Human)	242	FUNCTION: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736). {ECO:0000250|UniProtKB:O89094, ECO:0000269|PubMed:15301553, ECO:0000269|PubMed:15556625, ECO:0000269|PubMed:16854378, ECO:0000269|PubMed:19960512, ECO:0000269|PubMed:22825846, ECO:0000269|PubMed:24743736, ECO:0000305|PubMed:25121097}.	MISCELLANEOUS: Expressed in bacteria requires high concentrations of kosmotropic salts to be activated (PubMed:15301553). The mature and the intermediate form differ in activity towards synthetic caspase substrates: the p17/p10 mature form but not the p20/p8 intermediate form is active on WEHD-MCA; p20/p8 is active on a number of other caspase substrates without any marked preference (VEID-AFC, DEVD-AFC, LEVD-AFC and LEHD-AFC) (PubMed:22825846). {ECO:0000269|PubMed:15301553, ECO:0000269|PubMed:22825846}.	cornification [GO:0070268]; epidermis development [GO:0008544]; keratinization [GO:0031424]; proteolysis [GO:0006508]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; keratin filament [GO:0045095]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type endopeptidase activity [GO:0004197]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; keratin filament [GO:0045095]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type endopeptidase activity [GO:0004197]; cornification [GO:0070268]; epidermis development [GO:0008544]; keratinization [GO:0031424]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11175259, ECO:0000269|PubMed:12200134, ECO:0000269|PubMed:22825846}. Nucleus {ECO:0000269|PubMed:11175259}.
P31946	reviewed	1433B_HUMAN	14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]	YWHAB	Homo sapiens (Human)	246	FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}.		cytoplasmic sequestering of protein [GO:0051220]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of catalytic activity [GO:0043085]; protein targeting [GO:0006605]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuolar membrane [GO:0005774]	cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; phosphoserine residue binding [GO:0050815]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuolar membrane [GO:0005774]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; phosphoserine residue binding [GO:0050815]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860]; cytoplasmic sequestering of protein [GO:0051220]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of catalytic activity [GO:0043085]; protein targeting [GO:0006605]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:11260479}. Note=(Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG. {ECO:0000269|PubMed:11260479}.
P31947	reviewed	1433S_HUMAN	14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)	SFN HME1	Homo sapiens (Human)	248	FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. {ECO:0000269|PubMed:18382127}.; FUNCTION: p53-regulated inhibitor of G2/M progression. {ECO:0000269|PubMed:18382127}.		establishment of skin barrier [GO:0061436]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinization [GO:0031424]; keratinocyte development [GO:0003334]; keratinocyte proliferation [GO:0043616]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of protein export from nucleus [GO:0046827]; protein export from nucleus [GO:0006611]; protein kinase A signaling [GO:0010737]; regulation of cell cycle [GO:0051726]; regulation of epidermal cell division [GO:0010482]; release of cytochrome c from mitochondria [GO:0001836]; signal transduction [GO:0007165]; stem cell proliferation [GO:0072089]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; protein kinase binding [GO:0019901]; protein kinase C inhibitor activity [GO:0008426]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; protein kinase binding [GO:0019901]; protein kinase C inhibitor activity [GO:0008426]; establishment of skin barrier [GO:0061436]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinization [GO:0031424]; keratinocyte development [GO:0003334]; keratinocyte proliferation [GO:0043616]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of protein export from nucleus [GO:0046827]; protein export from nucleus [GO:0006611]; protein kinase A signaling [GO:0010737]; regulation of cell cycle [GO:0051726]; regulation of epidermal cell division [GO:0010482]; release of cytochrome c from mitochondria [GO:0001836]; signal transduction [GO:0007165]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.
P31948	reviewed	STIP1_HUMAN	Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)	STIP1	Homo sapiens (Human)	543	FUNCTION: Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}.		cellular response to interleukin-7 [GO:0098761]	cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]	Hsp90 protein binding [GO:0051879]; RNA binding [GO:0003723]	cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; Hsp90 protein binding [GO:0051879]; RNA binding [GO:0003723]; cellular response to interleukin-7 [GO:0098761]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q60864}. Nucleus {ECO:0000250|UniProtKB:Q60864}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q7ZWU1}.
P31949	reviewed	S10AB_HUMAN	Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]	S100A11 MLN70 S100C	Homo sapiens (Human)	105	FUNCTION: Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269|PubMed:18618420}.	MISCELLANEOUS: Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins. {ECO:0000250}.	negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; positive regulation of smooth muscle cell migration [GO:0014911]; signal transduction [GO:0007165]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774]	cadherin binding involved in cell-cell adhesion [GO:0098641]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774]; cadherin binding involved in cell-cell adhesion [GO:0098641]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; positive regulation of smooth muscle cell migration [GO:0014911]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18618420}. Nucleus {ECO:0000269|PubMed:18618420}.
P31994	reviewed	FCG2B_HUMAN	Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)	FCGR2B CD32 FCG2 IGFR2	Homo sapiens (Human)	310	FUNCTION: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.		antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; cellular response to molecule of bacterial origin [GO:0071219]; cerebellum development [GO:0021549]; defense response [GO:0006952]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; follicular B cell differentiation [GO:0002316]; follicular dendritic cell activation [GO:0002266]; immune complex clearance by monocytes and macrophages [GO:0002436]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; mature B cell differentiation involved in immune response [GO:0002313]; negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865]; negative regulation of antibody-dependent cellular cytotoxicity [GO:0001814]; negative regulation of B cell activation [GO:0050869]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002924]; negative regulation of immune response [GO:0050777]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of macrophage activation [GO:0043031]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of phagocytosis [GO:0050765]; negative regulation of type I hypersensitivity [GO:0001811]; phagocytosis, engulfment [GO:0006911]; positive regulation of humoral immune response [GO:0002922]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phagocytosis [GO:0050766]; positive regulation of response to endoplasmic reticulum stress [GO:1905898]; receptor-mediated endocytosis [GO:0006898]; regulation of adaptive immune response [GO:0002819]; regulation of B cell antigen processing and presentation [GO:0002622]; regulation of dendritic spine maintenance [GO:1902950]; regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903381]; regulation of immune complex clearance by monocytes and macrophages [GO:0090264]; regulation of immune response [GO:0050776]; regulation of innate immune response [GO:0045088]; regulation of signaling receptor activity [GO:0010469]; response to bacterium [GO:0009617]; signal transduction [GO:0007165]	cell body [GO:0044297]; dendritic spine [GO:0043197]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	amyloid-beta binding [GO:0001540]; IgG binding [GO:0019864]; low-affinity IgG receptor activity [GO:0019772]; protein-containing complex binding [GO:0044877]; transmembrane signaling receptor activity [GO:0004888]	cell body [GO:0044297]; dendritic spine [GO:0043197]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; amyloid-beta binding [GO:0001540]; IgG binding [GO:0019864]; low-affinity IgG receptor activity [GO:0019772]; protein-containing complex binding [GO:0044877]; transmembrane signaling receptor activity [GO:0004888]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; cellular response to molecule of bacterial origin [GO:0071219]; cerebellum development [GO:0021549]; defense response [GO:0006952]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; follicular B cell differentiation [GO:0002316]; follicular dendritic cell activation [GO:0002266]; immune complex clearance by monocytes and macrophages [GO:0002436]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; mature B cell differentiation involved in immune response [GO:0002313]; negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865]; negative regulation of antibody-dependent cellular cytotoxicity [GO:0001814]; negative regulation of B cell activation [GO:0050869]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002924]; negative regulation of immune response [GO:0050777]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of macrophage activation [GO:0043031]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of phagocytosis [GO:0050765]; negative regulation of type I hypersensitivity [GO:0001811]; phagocytosis, engulfment [GO:0006911]; positive regulation of humoral immune response [GO:0002922]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phagocytosis [GO:0050766]; positive regulation of response to endoplasmic reticulum stress [GO:1905898]; receptor-mediated endocytosis [GO:0006898]; regulation of adaptive immune response [GO:0002819]; regulation of B cell antigen processing and presentation [GO:0002622]; regulation of dendritic spine maintenance [GO:1902950]; regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903381]; regulation of immune complex clearance by monocytes and macrophages [GO:0090264]; regulation of immune response [GO:0050776]; regulation of innate immune response [GO:0045088]; regulation of signaling receptor activity [GO:0010469]; response to bacterium [GO:0009617]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P31995	reviewed	FCG2C_HUMAN	Low affinity immunoglobulin gamma Fc region receptor II-c (IgG Fc receptor II-c) (CDw32) (Fc-gamma RII-c) (Fc-gamma-RIIc) (FcRII-c) (CD antigen CD32)	FCGR2C CD32 FCG2 IGFR2	Homo sapiens (Human)	323	FUNCTION: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.		cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; regulation of immune response [GO:0050776]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	IgG binding [GO:0019864]; transmembrane signaling receptor activity [GO:0004888]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; IgG binding [GO:0019864]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: [Isoform IIC4]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform IIC3]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform IIC2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform IIC1]: Cell membrane; Single-pass type I membrane protein.
P31997	reviewed	CEAM8_HUMAN	Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)	CEACAM8 CGM6	Homo sapiens (Human)	349	FUNCTION: Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). {ECO:0000269|PubMed:11590190, ECO:0000269|PubMed:2022629, ECO:0000269|PubMed:8776764}.		heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955]	azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	protein heterodimerization activity [GO:0046982]	azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; protein heterodimerization activity [GO:0046982]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2208113}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2208113}. Cell surface {ECO:0000269|PubMed:8776764}.
P32004	reviewed	L1CAM_HUMAN	Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171)	L1CAM CAML1 MIC5	Homo sapiens (Human)	1257	FUNCTION: Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. {ECO:0000269|PubMed:20621658, ECO:0000305}.		axon development [GO:0061564]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; chemotaxis [GO:0006935]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; positive regulation of axon extension [GO:0045773]; synapse organization [GO:0050808]	axon [GO:0030424]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	axon guidance receptor activity [GO:0008046]; protein domain specific binding [GO:0019904]	axon [GO:0030424]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; axon guidance receptor activity [GO:0008046]; protein domain specific binding [GO:0019904]; axon development [GO:0061564]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; chemotaxis [GO:0006935]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; positive regulation of axon extension [GO:0045773]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12514225, ECO:0000269|PubMed:20621658, ECO:0000269|PubMed:22973895, ECO:0000269|PubMed:26891472}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q05695}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q05695}. Cell projection, axon {ECO:0000269|PubMed:20621658}. Cell projection, dendrite. Note=Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658). {ECO:0000250|UniProtKB:Q05695, ECO:0000269|PubMed:20621658}.
P32019	reviewed	I5P2_HUMAN	Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)	INPP5B OCRL2	Homo sapiens (Human)	993	FUNCTION: Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. {ECO:0000269|PubMed:7721860}.		flagellated sperm motility [GO:0030317]; in utero embryonic development [GO:0001701]; inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of protein processing [GO:0070613]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; metal ion binding [GO:0046872]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; metal ion binding [GO:0046872]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; flagellated sperm motility [GO:0030317]; in utero embryonic development [GO:0001701]; inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of protein processing [GO:0070613]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:7721860}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:17956944}. Early endosome membrane {ECO:0000269|PubMed:17956944}. Membrane {ECO:0000269|PubMed:7721860}; Peripheral membrane protein {ECO:0000305|PubMed:7721860}; Cytoplasmic side {ECO:0000305|PubMed:7721860}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q8K337}. Golgi apparatus {ECO:0000269|PubMed:17956944}.
P32119	reviewed	PRDX2_HUMAN	Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2)	PRDX2 NKEFB TDPX1	Homo sapiens (Human)	198	FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). {ECO:0000269|PubMed:9497357}.	MISCELLANEOUS: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin. {ECO:0000305|PubMed:27892488}.; MISCELLANEOUS: [Isoform 2]: Due to intron retention. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; defense response to tumor cell [GO:0002357]; extrinsic apoptotic signaling pathway [GO:0097191]; hydrogen peroxide catabolic process [GO:0042744]; leukocyte activation [GO:0045321]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of T cell differentiation [GO:0045581]; positive regulation of blood coagulation [GO:0030194]; positive regulation of MAPK cascade [GO:0043410]; regulation of apoptotic process [GO:0042981]; regulation of hydrogen peroxide metabolic process [GO:0010310]; removal of superoxide radicals [GO:0019430]; respiratory burst involved in inflammatory response [GO:0002536]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; thymus development [GO:0048538]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	antioxidant activity [GO:0016209]; thioredoxin peroxidase activity [GO:0008379]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; antioxidant activity [GO:0016209]; thioredoxin peroxidase activity [GO:0008379]; cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; defense response to tumor cell [GO:0002357]; extrinsic apoptotic signaling pathway [GO:0097191]; hydrogen peroxide catabolic process [GO:0042744]; leukocyte activation [GO:0045321]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of T cell differentiation [GO:0045581]; positive regulation of blood coagulation [GO:0030194]; positive regulation of MAPK cascade [GO:0043410]; regulation of apoptotic process [GO:0042981]; regulation of hydrogen peroxide metabolic process [GO:0010310]; removal of superoxide radicals [GO:0019430]; respiratory burst involved in inflammatory response [GO:0002536]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; thymus development [GO:0048538]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9497357}.
P32121	reviewed	ARRB2_HUMAN	Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)	ARRB2 ARB2 ARR2	Homo sapiens (Human)	409	FUNCTION: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires GRK2. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN (PubMed:26839314). Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3. Acts as an adapter protein coupling FFAR4 receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed:22282525, PubMed:23809162). During the activation step of NLRP3 inflammasome, directly associates with NLRP3 leading to inhibition of pro-inflammatory cytokine release and inhibition of inflammation (PubMed:23809162). {ECO:0000269|PubMed:10644702, ECO:0000269|PubMed:11877451, ECO:0000269|PubMed:12488444, ECO:0000269|PubMed:12582207, ECO:0000269|PubMed:12949261, ECO:0000269|PubMed:12958365, ECO:0000269|PubMed:14711824, ECO:0000269|PubMed:15054093, ECO:0000269|PubMed:15125834, ECO:0000269|PubMed:15205453, ECO:0000269|PubMed:15475570, ECO:0000269|PubMed:15618519, ECO:0000269|PubMed:15635042, ECO:0000269|PubMed:15671180, ECO:0000269|PubMed:15699339, ECO:0000269|PubMed:15878855, ECO:0000269|PubMed:16144840, ECO:0000269|PubMed:16280323, ECO:0000269|PubMed:16378096, ECO:0000269|PubMed:16492667, ECO:0000269|PubMed:16820410, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:18419762, ECO:0000269|PubMed:18604210, ECO:0000269|PubMed:19325136, ECO:0000269|PubMed:19620252, ECO:0000269|PubMed:19643177, ECO:0000269|PubMed:20048153, ECO:0000269|PubMed:22282525, ECO:0000269|PubMed:22457824, ECO:0000269|PubMed:23809162, ECO:0000269|PubMed:26839314}.		adult walking behavior [GO:0007628]; cell chemotaxis [GO:0060326]; desensitization of G protein-coupled receptor signaling pathway by arrestin [GO:0002032]; dopamine receptor signaling pathway [GO:0007212]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled receptor internalization [GO:0002031]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; postsynaptic signal transduction [GO:0098926]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; receptor internalization [GO:0031623]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]	clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	angiotensin receptor binding [GO:0031701]; D1 dopamine receptor binding [GO:0031748]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; molecular adaptor activity [GO:0060090]; protein kinase B binding [GO:0043422]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]	clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; angiotensin receptor binding [GO:0031701]; D1 dopamine receptor binding [GO:0031748]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; molecular adaptor activity [GO:0060090]; protein kinase B binding [GO:0043422]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; adult walking behavior [GO:0007628]; cell chemotaxis [GO:0060326]; desensitization of G protein-coupled receptor signaling pathway by arrestin [GO:0002032]; dopamine receptor signaling pathway [GO:0007212]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled receptor internalization [GO:0002031]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; postsynaptic signal transduction [GO:0098926]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; receptor internalization [GO:0031623]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.
P32189	reviewed	GLPK_HUMAN	Glycerol kinase (GK) (Glycerokinase) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase)	GK	Homo sapiens (Human)	559	FUNCTION: Key enzyme in the regulation of glycerol uptake and metabolism.		glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; glycerol-3-phosphate biosynthetic process [GO:0046167]; phosphorylation [GO:0016310]; triglyceride biosynthetic process [GO:0019432]; triglyceride metabolic process [GO:0006641]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; glycerol kinase activity [GO:0004370]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; glycerol kinase activity [GO:0004370]; glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; glycerol-3-phosphate biosynthetic process [GO:0046167]; phosphorylation [GO:0016310]; triglyceride biosynthetic process [GO:0019432]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.
P32238	reviewed	CCKAR_HUMAN	Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R)	CCKAR CCKRA	Homo sapiens (Human)	428	FUNCTION: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.		axonogenesis [GO:0007409]; cellular response to hormone stimulus [GO:0032870]; cholecystokinin signaling pathway [GO:0038188]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; neuron migration [GO:0001764]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of hormone secretion [GO:0046883]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	cholecystokinin receptor activity [GO:0004951]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cholecystokinin receptor activity [GO:0004951]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; axonogenesis [GO:0007409]; cellular response to hormone stimulus [GO:0032870]; cholecystokinin signaling pathway [GO:0038188]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; neuron migration [GO:0001764]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of hormone secretion [GO:0046883]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P32239	reviewed	GASR_HUMAN	Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R)	CCKBR CCKRB	Homo sapiens (Human)	447	FUNCTION: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; FUNCTION: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.		cell surface receptor signaling pathway [GO:0007166]; cholecystokinin signaling pathway [GO:0038188]; digestive tract development [GO:0048565]; gastric acid secretion [GO:0001696]; gland development [GO:0048732]; pH reduction [GO:0045851]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; cholecystokinin receptor activity [GO:0004951]; gastrin receptor activity [GO:0015054]; peptide hormone binding [GO:0017046]; type B gastrin/cholecystokinin receptor binding [GO:0031741]	intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; cholecystokinin receptor activity [GO:0004951]; gastrin receptor activity [GO:0015054]; peptide hormone binding [GO:0017046]; type B gastrin/cholecystokinin receptor binding [GO:0031741]; cell surface receptor signaling pathway [GO:0007166]; cholecystokinin signaling pathway [GO:0038188]; digestive tract development [GO:0048565]; gastric acid secretion [GO:0001696]; gland development [GO:0048732]; pH reduction [GO:0045851]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P32241	reviewed	VIPR1_HUMAN	Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1)	VIPR1	Homo sapiens (Human)	457	FUNCTION: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38. {ECO:0000269|PubMed:8926282}.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; positive regulation of cell population proliferation [GO:0008284]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; vasoactive intestinal polypeptide receptor activity [GO:0004999]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; vasoactive intestinal polypeptide receptor activity [GO:0004999]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P32242	reviewed	OTX1_HUMAN	Homeobox protein OTX1 (Orthodenticle homolog 1)	OTX1	Homo sapiens (Human)	354	FUNCTION: Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.		anterior/posterior pattern specification [GO:0009952]; diencephalon morphogenesis [GO:0048852]; inner ear morphogenesis [GO:0042472]; metencephalon development [GO:0022037]; midbrain development [GO:0030901]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; diencephalon morphogenesis [GO:0048852]; inner ear morphogenesis [GO:0042472]; metencephalon development [GO:0022037]; midbrain development [GO:0030901]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P32243	reviewed	OTX2_HUMAN	Homeobox protein OTX2 (Orthodenticle homolog 2)	OTX2	Homo sapiens (Human)	289	FUNCTION: Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'. {ECO:0000269|PubMed:22715480}.		axon guidance [GO:0007411]; dopaminergic neuron differentiation [GO:0071542]; forebrain development [GO:0030900]; midbrain development [GO:0030901]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; protein-containing complex assembly [GO:0065003]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; growth cone [GO:0030426]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; eukaryotic initiation factor 4E binding [GO:0008190]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; growth cone [GO:0030426]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; eukaryotic initiation factor 4E binding [GO:0008190]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; axon guidance [GO:0007411]; dopaminergic neuron differentiation [GO:0071542]; forebrain development [GO:0030900]; midbrain development [GO:0030901]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; protein-containing complex assembly [GO:0065003]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19414065}.
P32245	reviewed	MC4R_HUMAN	Melanocortin receptor 4 (MC4-R)	MC4R	Homo sapiens (Human)	332	FUNCTION: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). {ECO:0000269|PubMed:12646665, ECO:0000269|PubMed:25163632}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; diet induced thermogenesis [GO:0002024]; energy reserve metabolic process [GO:0006112]; feeding behavior [GO:0007631]; insulin secretion [GO:0030073]; negative regulation of feeding behavior [GO:2000252]; positive regulation of bone resorption [GO:0045780]; regulation of eating behavior [GO:1903998]; regulation of grooming behavior [GO:2000821]; regulation of metabolic process [GO:0019222]; response to insulin [GO:0032868]; response to melanocyte-stimulating hormone [GO:1990680]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	melanocortin receptor activity [GO:0004977]; melanocyte-stimulating hormone receptor activity [GO:0004980]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; melanocortin receptor activity [GO:0004977]; melanocyte-stimulating hormone receptor activity [GO:0004980]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]; ubiquitin protein ligase binding [GO:0031625]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; diet induced thermogenesis [GO:0002024]; energy reserve metabolic process [GO:0006112]; feeding behavior [GO:0007631]; insulin secretion [GO:0030073]; negative regulation of feeding behavior [GO:2000252]; positive regulation of bone resorption [GO:0045780]; regulation of eating behavior [GO:1903998]; regulation of grooming behavior [GO:2000821]; regulation of metabolic process [GO:0019222]; response to insulin [GO:0032868]; response to melanocyte-stimulating hormone [GO:1990680]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25163632}; Multi-pass membrane protein {ECO:0000255}.
P32246	reviewed	CCR1_HUMAN	C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)	CCR1 CMKBR1 CMKR1 SCYAR1	Homo sapiens (Human)	355	FUNCTION: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.		calcium ion transport [GO:0006816]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; dendritic cell chemotaxis [GO:0002407]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of bone mineralization [GO:0030502]; negative regulation of gene expression [GO:0010629]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of osteoclast differentiation [GO:0045672]; response to wounding [GO:0009611]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine (C-C motif) ligand 5 binding [GO:0071791]; chemokine (C-C motif) ligand 7 binding [GO:0035717]; chemokine receptor activity [GO:0004950]; phosphatidylinositol phospholipase C activity [GO:0004435]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine (C-C motif) ligand 5 binding [GO:0071791]; chemokine (C-C motif) ligand 7 binding [GO:0035717]; chemokine receptor activity [GO:0004950]; phosphatidylinositol phospholipase C activity [GO:0004435]; calcium ion transport [GO:0006816]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; dendritic cell chemotaxis [GO:0002407]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of bone mineralization [GO:0030502]; negative regulation of gene expression [GO:0010629]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of osteoclast differentiation [GO:0045672]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18587271}; Multi-pass membrane protein {ECO:0000269|PubMed:18587271}.
P32247	reviewed	BRS3_HUMAN	Bombesin receptor subtype-3 (BRS-3)	BRS3	Homo sapiens (Human)	399	FUNCTION: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.		adult feeding behavior [GO:0008343]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose metabolic process [GO:0006006]; regulation of blood pressure [GO:0008217]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bombesin receptor activity [GO:0004946]; neuropeptide receptor activity [GO:0008188]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bombesin receptor activity [GO:0004946]; neuropeptide receptor activity [GO:0008188]; adult feeding behavior [GO:0008343]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose metabolic process [GO:0006006]; regulation of blood pressure [GO:0008217]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P32248	reviewed	CCR7_HUMAN	C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197)	CCR7 CMKBR7 EBI1 EVI1	Homo sapiens (Human)	378	FUNCTION: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.		activation of GTPase activity [GO:0090630]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cellular response to cytokine stimulus [GO:0071345]; dendritic cell chemotaxis [GO:0002407]; establishment of T cell polarity [GO:0001768]; G protein-coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells [GO:0048872]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte migration into lymph node [GO:0097022]; mature conventional dendritic cell differentiation [GO:0097029]; myeloid dendritic cell chemotaxis [GO:0002408]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of interleukin-12 production [GO:0032695]; negative thymic T cell selection [GO:0045060]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell motility [GO:2000147]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation [GO:2000526]; positive regulation of humoral immune response [GO:0002922]; positive regulation of hypersensitivity [GO:0002885]; positive regulation of immunological synapse formation [GO:2000522]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of T cell costimulation [GO:2000525]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of dendritic cell dendrite assembly [GO:2000547]; regulation of interleukin-1 beta production [GO:0032651]; regulation of type II interferon production [GO:0032649]; release of sequestered calcium ion into cytosol [GO:0051209]; response to lipopolysaccharide [GO:0032496]; response to nitric oxide [GO:0071731]; response to prostaglandin E [GO:0034695]; ruffle organization [GO:0031529]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	C-C chemokine receptor activity [GO:0016493]; C-C motif chemokine 19 receptor activity [GO:0038117]; C-C motif chemokine 21 receptor activity [GO:0038121]; chemokine (C-C motif) ligand 19 binding [GO:0035757]; chemokine (C-C motif) ligand 21 binding [GO:0035758]; G protein-coupled receptor activity [GO:0004930]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; C-C chemokine receptor activity [GO:0016493]; C-C motif chemokine 19 receptor activity [GO:0038117]; C-C motif chemokine 21 receptor activity [GO:0038121]; chemokine (C-C motif) ligand 19 binding [GO:0035757]; chemokine (C-C motif) ligand 21 binding [GO:0035758]; G protein-coupled receptor activity [GO:0004930]; activation of GTPase activity [GO:0090630]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cellular response to cytokine stimulus [GO:0071345]; dendritic cell chemotaxis [GO:0002407]; establishment of T cell polarity [GO:0001768]; G protein-coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells [GO:0048872]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte migration into lymph node [GO:0097022]; mature conventional dendritic cell differentiation [GO:0097029]; myeloid dendritic cell chemotaxis [GO:0002408]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of interleukin-12 production [GO:0032695]; negative thymic T cell selection [GO:0045060]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell motility [GO:2000147]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation [GO:2000526]; positive regulation of humoral immune response [GO:0002922]; positive regulation of hypersensitivity [GO:0002885]; positive regulation of immunological synapse formation [GO:2000522]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of T cell costimulation [GO:2000525]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of dendritic cell dendrite assembly [GO:2000547]; regulation of interleukin-1 beta production [GO:0032651]; regulation of type II interferon production [GO:0032649]; release of sequestered calcium ion into cytosol [GO:0051209]; response to lipopolysaccharide [GO:0032496]; response to nitric oxide [GO:0071731]; response to prostaglandin E [GO:0034695]; ruffle organization [GO:0031529]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P32249	reviewed	GP183_HUMAN	G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)	GPR183 EBI2	Homo sapiens (Human)	361	FUNCTION: G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity). {ECO:0000250|UniProtKB:Q3U6B2, ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:21673108, ECO:0000269|PubMed:21796212, ECO:0000269|PubMed:22875855, ECO:0000269|PubMed:22913878, ECO:0000269|PubMed:22930711, ECO:0000269|PubMed:25297897}.	MISCELLANEOUS: GSK682753A (8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one), an inverse agonist, selectively inhibits the constitutive activity of GPR183 with high potency and efficacy (PubMed:21673108, PubMed:23772388). Specifically inhibited by NIBR189 ((2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one). {ECO:0000269|PubMed:21673108, ECO:0000269|PubMed:23772388}.	adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; dendritic cell chemotaxis [GO:0002407]; dendritic cell homeostasis [GO:0036145]; G protein-coupled receptor signaling pathway [GO:0007186]; humoral immune response [GO:0006959]; immune response [GO:0006955]; leukocyte chemotaxis [GO:0030595]; mature B cell differentiation involved in immune response [GO:0002313]; osteoclast differentiation [GO:0030316]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of astrocyte chemotaxis [GO:2000458]; T cell chemotaxis [GO:0010818]; T follicular helper cell differentiation [GO:0061470]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; oxysterol binding [GO:0008142]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; oxysterol binding [GO:0008142]; adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; dendritic cell chemotaxis [GO:0002407]; dendritic cell homeostasis [GO:0036145]; G protein-coupled receptor signaling pathway [GO:0007186]; humoral immune response [GO:0006959]; immune response [GO:0006955]; leukocyte chemotaxis [GO:0030595]; mature B cell differentiation involved in immune response [GO:0002313]; osteoclast differentiation [GO:0030316]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of astrocyte chemotaxis [GO:2000458]; T cell chemotaxis [GO:0010818]; T follicular helper cell differentiation [GO:0061470]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:18628402, ECO:0000269|PubMed:21673108, ECO:0000269|PubMed:22930711}; Multi-pass membrane protein {ECO:0000255}.
P32297	reviewed	ACHA3_HUMAN	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3 NACHRA3	Homo sapiens (Human)	505	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. {ECO:0000269|PubMed:31708116}.		acetylcholine receptor signaling pathway [GO:0095500]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; behavioral response to nicotine [GO:0035095]; excitatory postsynaptic potential [GO:0060079]; locomotory behavior [GO:0007626]; monoatomic ion transport [GO:0006811]; nervous system development [GO:0007399]; regulation of acetylcholine secretion, neurotransmission [GO:0014056]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane potential [GO:0042391]; regulation of smooth muscle contraction [GO:0006940]; response to acetylcholine [GO:1905144]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]	acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]; acetylcholine receptor signaling pathway [GO:0095500]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; behavioral response to nicotine [GO:0035095]; excitatory postsynaptic potential [GO:0060079]; locomotory behavior [GO:0007626]; monoatomic ion transport [GO:0006811]; nervous system development [GO:0007399]; regulation of acetylcholine secretion, neurotransmission [GO:0014056]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane potential [GO:0042391]; regulation of smooth muscle contraction [GO:0006940]; response to acetylcholine [GO:1905144]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane {ECO:0000269|PubMed:31708116}; Multi-pass membrane protein.
P32298	reviewed	GRK4_HUMAN	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1)	GRK4 GPRK2L GPRK4	Homo sapiens (Human)	578	FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}.		phosphorylation [GO:0016310]; receptor internalization [GO:0031623]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; regulation of signal transduction [GO:0009966]; signal transduction [GO:0007165]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; rhodopsin kinase activity [GO:0050254]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; rhodopsin kinase activity [GO:0050254]; phosphorylation [GO:0016310]; receptor internalization [GO:0031623]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; regulation of signal transduction [GO:0009966]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.
P32302	reviewed	CXCR5_HUMAN	C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1) (Monocyte-derived receptor 15) (MDR-15) (CD antigen CD185)	CXCR5 BLR1 MDR15	Homo sapiens (Human)	372	FUNCTION: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.		B cell activation [GO:0042113]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; leukocyte chemotaxis [GO:0030595]; lymph node development [GO:0048535]; positive regulation of cytokinesis [GO:0032467]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine receptor activity [GO:0016494]; G protein-coupled receptor activity [GO:0004930]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine receptor activity [GO:0016494]; G protein-coupled receptor activity [GO:0004930]; B cell activation [GO:0042113]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; leukocyte chemotaxis [GO:0030595]; lymph node development [GO:0048535]; positive regulation of cytokinesis [GO:0032467]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P32320	reviewed	CDD_HUMAN	Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase)	CDA CDD	Homo sapiens (Human)	146	FUNCTION: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. {ECO:0000269|PubMed:7923172, ECO:0000269|PubMed:9596658}.		cell surface receptor signaling pathway [GO:0007166]; cellular response to external biotic stimulus [GO:0071217]; cytidine deamination [GO:0009972]; cytosine metabolic process [GO:0019858]; negative regulation of cell growth [GO:0030308]; negative regulation of nucleotide metabolic process [GO:0045980]; pyrimidine-containing compound salvage [GO:0008655]; response to cycloheximide [GO:0046898]; UMP salvage [GO:0044206]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]	cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; identical protein binding [GO:0042802]; nucleoside binding [GO:0001882]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]; cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; identical protein binding [GO:0042802]; nucleoside binding [GO:0001882]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; cell surface receptor signaling pathway [GO:0007166]; cellular response to external biotic stimulus [GO:0071217]; cytidine deamination [GO:0009972]; cytosine metabolic process [GO:0019858]; negative regulation of cell growth [GO:0030308]; negative regulation of nucleotide metabolic process [GO:0045980]; pyrimidine-containing compound salvage [GO:0008655]; response to cycloheximide [GO:0046898]; UMP salvage [GO:0044206]	
P32321	reviewed	DCTD_HUMAN	Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase)	DCTD	Homo sapiens (Human)	178	FUNCTION: Supplies the nucleotide substrate for thymidylate synthetase.		nucleotide biosynthetic process [GO:0009165]; pyrimidine nucleotide metabolic process [GO:0006220]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	dCMP deaminase activity [GO:0004132]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dCMP deaminase activity [GO:0004132]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; nucleotide biosynthetic process [GO:0009165]; pyrimidine nucleotide metabolic process [GO:0006220]	
P32322	reviewed	P5CR1_HUMAN	Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)	PYCR1	Homo sapiens (Human)	319	FUNCTION: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. {ECO:0000269|PubMed:16730026, ECO:0000269|PubMed:19648921}.		cellular response to oxidative stress [GO:0034599]; L-proline biosynthetic process [GO:0055129]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; proline biosynthetic process [GO:0006561]; regulation of mitochondrial membrane potential [GO:0051881]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	identical protein binding [GO:0042802]; pyrroline-5-carboxylate reductase activity [GO:0004735]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; identical protein binding [GO:0042802]; pyrroline-5-carboxylate reductase activity [GO:0004735]; cellular response to oxidative stress [GO:0034599]; L-proline biosynthetic process [GO:0055129]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; proline biosynthetic process [GO:0006561]; regulation of mitochondrial membrane potential [GO:0051881]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19648921}.
P32418	reviewed	NAC1_HUMAN	Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1)	SLC8A1 CNC NCX1	Homo sapiens (Human)	973	FUNCTION: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:1374913, PubMed:11241183, PubMed:1476165). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum (PubMed:1374913, PubMed:11241183, PubMed:1476165). SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:1374913, PubMed:11241183, PubMed:1476165). Required for normal embryonic heart development and the onset of heart contractions (By similarity). {ECO:0000250|UniProtKB:P70414, ECO:0000269|PubMed:11241183, ECO:0000269|PubMed:1374913, ECO:0000269|PubMed:1476165}.		calcium ion export [GO:1901660]; calcium ion homeostasis [GO:0055074]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to caffeine [GO:0071313]; cellular response to reactive oxygen species [GO:0034614]; intracellular calcium ion homeostasis [GO:0006874]; intracellular sodium ion homeostasis [GO:0006883]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; monoatomic ion transport [GO:0006811]; muscle contraction [GO:0006936]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; positive regulation of bone mineralization [GO:0030501]; positive regulation of the force of heart contraction [GO:0098735]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of gene expression [GO:0010468]; regulation of heart rate [GO:0002027]; regulation of the force of heart contraction [GO:0002026]; relaxation of cardiac muscle [GO:0055119]; relaxation of smooth muscle [GO:0044557]; response to muscle stretch [GO:0035994]; sodium ion export across plasma membrane [GO:0036376]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; vascular associated smooth muscle contraction [GO:0014829]	axon [GO:0030424]; axon terminus [GO:0043679]; cell periphery [GO:0071944]; dendrite [GO:0030425]; intercalated disc [GO:0014704]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; sarcolemma [GO:0042383]; synapse [GO:0045202]; T-tubule [GO:0030315]; Z disc [GO:0030018]	ankyrin binding [GO:0030506]; calcium ion binding [GO:0005509]; calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; cytoskeletal protein binding [GO:0008092]; transmembrane transporter binding [GO:0044325]	axon [GO:0030424]; axon terminus [GO:0043679]; cell periphery [GO:0071944]; dendrite [GO:0030425]; intercalated disc [GO:0014704]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; sarcolemma [GO:0042383]; synapse [GO:0045202]; T-tubule [GO:0030315]; Z disc [GO:0030018]; ankyrin binding [GO:0030506]; calcium ion binding [GO:0005509]; calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; cytoskeletal protein binding [GO:0008092]; transmembrane transporter binding [GO:0044325]; calcium ion export [GO:1901660]; calcium ion homeostasis [GO:0055074]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to caffeine [GO:0071313]; cellular response to reactive oxygen species [GO:0034614]; intracellular calcium ion homeostasis [GO:0006874]; intracellular sodium ion homeostasis [GO:0006883]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; monoatomic ion transport [GO:0006811]; muscle contraction [GO:0006936]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; positive regulation of bone mineralization [GO:0030501]; positive regulation of the force of heart contraction [GO:0098735]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of gene expression [GO:0010468]; regulation of heart rate [GO:0002027]; regulation of the force of heart contraction [GO:0002026]; relaxation of cardiac muscle [GO:0055119]; relaxation of smooth muscle [GO:0044557]; response to muscle stretch [GO:0035994]; sodium ion export across plasma membrane [GO:0036376]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; vascular associated smooth muscle contraction [GO:0014829]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11241183, ECO:0000269|PubMed:1374913, ECO:0000269|PubMed:1476165}; Multi-pass membrane protein {ECO:0000269|PubMed:23376057}.
P32455	reviewed	GBP1_HUMAN	Guanylate-binding protein 1 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 1) (GBP-1) (HuGBP-1) (hGBP1) (Guanine nucleotide-binding protein 1) (Interferon-induced guanylate-binding protein 1)	GBP1	Homo sapiens (Human)	592	FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:22106366, PubMed:29144452, PubMed:16511497, PubMed:31268602). Hydrolyzes GTP to GMP in two consecutive cleavage reactions: GTP is first hydrolyzed to GDP and then to GMP in a processive manner (PubMed:7512561, PubMed:16511497). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and promotes both autophagy and inflammasome assembly (PubMed:29144452, PubMed:31268602). Promotes host defense against bacterial infections by regulating bacteriolytic peptide generation via its interaction with ubiquitin-binding protein SQSTM1, which delivers monoubiquitinated proteins to autolysosomes for the generation of bacteriolytic peptides (By similarity). Also acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:31268602). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:31268602). Confers protection to several pathogens, including the bacterial pathogens L.monocytogenes and M.bovis BCG as well as the protozoan pathogen T.gondii (PubMed:31268602). Exhibits antiviral activity against influenza virus (PubMed:22106366). {ECO:0000250|UniProtKB:Q01514, ECO:0000269|PubMed:16511497, ECO:0000269|PubMed:22106366, ECO:0000269|PubMed:29144452, ECO:0000269|PubMed:31268602, ECO:0000269|PubMed:7512561}.		cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; negative regulation of T cell receptor signaling pathway [GO:0050860]; non-canonical inflammasome complex assembly [GO:0160075]; positive regulation of pyroptosis [GO:0140639]; protein localization to vacuole [GO:0072665]; regulation of calcium-mediated signaling [GO:0050848]; regulation of protein localization to plasma membrane [GO:1903076]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]; vesicle membrane [GO:0012506]	actin binding [GO:0003779]; cytokine binding [GO:0019955]; enzyme binding [GO:0019899]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GDP phosphatase activity [GO:0004382]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; spectrin binding [GO:0030507]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]; vesicle membrane [GO:0012506]; actin binding [GO:0003779]; cytokine binding [GO:0019955]; enzyme binding [GO:0019899]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GDP phosphatase activity [GO:0004382]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; spectrin binding [GO:0030507]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; negative regulation of T cell receptor signaling pathway [GO:0050860]; non-canonical inflammasome complex assembly [GO:0160075]; positive regulation of pyroptosis [GO:0140639]; protein localization to vacuole [GO:0072665]; regulation of calcium-mediated signaling [GO:0050848]; regulation of protein localization to plasma membrane [GO:1903076]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:29144452, ECO:0000269|PubMed:29233899, ECO:0000269|PubMed:31268602}; Lipid-anchor {ECO:0000269|PubMed:21151871}; Cytoplasmic side {ECO:0000269|PubMed:21151871}. Golgi apparatus membrane {ECO:0000269|PubMed:15937107}; Lipid-anchor {ECO:0000269|PubMed:21151871}; Cytoplasmic side {ECO:0000269|PubMed:21151871}. Cell membrane {ECO:0000269|PubMed:21151871}; Lipid-anchor {ECO:0000269|PubMed:21151871}; Cytoplasmic side {ECO:0000269|PubMed:21151871}. Cytoplasm {ECO:0000269|PubMed:21151871}. Secreted {ECO:0000269|PubMed:16936281}. Note=Localizes to pathogen-containing vacuoles or to the cell surface of bacteria that escaped vacuoles (PubMed:29144452, PubMed:31268602). Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction (PubMed:16936281). Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor (PubMed:15937107). {ECO:0000269|PubMed:15937107, ECO:0000269|PubMed:16936281, ECO:0000269|PubMed:29144452, ECO:0000269|PubMed:31268602}.
P32456	reviewed	GBP2_HUMAN	Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2)	GBP2	Homo sapiens (Human)	591	FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:31091448). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Confers protection to the protozoan pathogen Toxoplasma gondii (By similarity). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:31091448). {ECO:0000250|UniProtKB:Q9Z0E6, ECO:0000269|PubMed:31091448, ECO:0000269|PubMed:8706832}.		activation of innate immune response [GO:0002218]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response [GO:0006955]; positive regulation of AIM2 inflammasome complex assembly [GO:0140973]; positive regulation of pyroptosis [GO:0140639]; protein localization to nucleus [GO:0034504]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	endopeptidase inhibitor activity [GO:0004866]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; endopeptidase inhibitor activity [GO:0004866]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; protein homodimerization activity [GO:0042803]; activation of innate immune response [GO:0002218]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response [GO:0006955]; positive regulation of AIM2 inflammasome complex assembly [GO:0140973]; positive regulation of pyroptosis [GO:0140639]; protein localization to nucleus [GO:0034504]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9Z0E6}; Lipid-anchor {ECO:0000269|PubMed:21151871}. Golgi apparatus membrane {ECO:0000269|PubMed:21151871, ECO:0000269|PubMed:31091448}; Lipid-anchor {ECO:0000269|PubMed:21151871}. Cytoplasm {ECO:0000269|PubMed:21151871}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21151871}. Note=GBP2-GBP5 dimers localize to the Golgi apparatus. {ECO:0000269|PubMed:21151871}.
P32519	reviewed	ELF1_HUMAN	ETS-related transcription factor Elf-1 (E74-like factor 1)	ELF1	Homo sapiens (Human)	619	FUNCTION: Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}.		negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production [GO:0001817]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production [GO:0001817]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P32745	reviewed	SSR3_HUMAN	Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SST3) (SSR-28)	SSTR3	Homo sapiens (Human)	418	FUNCTION: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. {ECO:0000269|PubMed:1337145}.		cell-cell signaling [GO:0007267]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucocorticoid stimulus [GO:0071385]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated apoptotic signaling pathway [GO:0008628]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; response to starvation [GO:0042594]; spermatogenesis [GO:0007283]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; signaling receptor binding [GO:0005102]; somatostatin receptor activity [GO:0004994]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; signaling receptor binding [GO:0005102]; somatostatin receptor activity [GO:0004994]; cell-cell signaling [GO:0007267]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucocorticoid stimulus [GO:0071385]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated apoptotic signaling pathway [GO:0008628]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; response to starvation [GO:0042594]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Internalized into endoplasmic vesicles upon somatostatin-stimulation. {ECO:0000250}.
P32754	reviewed	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase)	HPD PPD	Homo sapiens (Human)	393	FUNCTION: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism. {ECO:0000269|PubMed:1339442}.		L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]	4-hydroxyphenylpyruvate dioxygenase activity [GO:0003868]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; 4-hydroxyphenylpyruvate dioxygenase activity [GO:0003868]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P32755}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32755}; Peripheral membrane protein {ECO:0000250|UniProtKB:P32755}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P32755}; Peripheral membrane protein {ECO:0000250|UniProtKB:P32755}.
P32780	reviewed	TF2H1_HUMAN	General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit)	GTF2H1 BTF2	Homo sapiens (Human)	548	FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000269|PubMed:9852112}.		DNA repair [GO:0006281]; hormone-mediated signaling pathway [GO:0009755]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]	nucleoplasm [GO:0005654]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]	chromatin binding [GO:0003682]; nuclear thyroid hormone receptor binding [GO:0046966]	nucleoplasm [GO:0005654]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; chromatin binding [GO:0003682]; nuclear thyroid hormone receptor binding [GO:0046966]; DNA repair [GO:0006281]; hormone-mediated signaling pathway [GO:0009755]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
P32856	reviewed	STX2_HUMAN	Syntaxin-2 (Epimorphin)	STX2 EPIM STX2A STX2B STX2C	Homo sapiens (Human)	288	FUNCTION: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.		acrosome reaction [GO:0007340]; animal organ morphogenesis [GO:0009887]; cellular response to oxidative stress [GO:0034599]; cornified envelope assembly [GO:1903575]; ectoderm development [GO:0007398]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; signal transduction [GO:0007165]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]	basolateral plasma membrane [GO:0016323]; endomembrane system [GO:0012505]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]	calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; structural molecule activity [GO:0005198]	basolateral plasma membrane [GO:0016323]; endomembrane system [GO:0012505]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; structural molecule activity [GO:0005198]; acrosome reaction [GO:0007340]; animal organ morphogenesis [GO:0009887]; cellular response to oxidative stress [GO:0034599]; cornified envelope assembly [GO:1903575]; ectoderm development [GO:0007398]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; signal transduction [GO:0007165]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]	SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein.
P32881	reviewed	IFNA8_HUMAN	Interferon alpha-8 (IFN-alpha-8) (Interferon alpha-B) (LeIF B) (Interferon alpha-B2)	IFNA8	Homo sapiens (Human)	189	FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
P32926	reviewed	DSG3_HUMAN	Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6)	DSG3 CDHF6	Homo sapiens (Human)	999	FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	MISCELLANEOUS: Pemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion caused by the action of autoantibodies against desmoglein 3. {ECO:0000269|PubMed:1720352}.	cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, desmosome {ECO:0000305}.
P32927	reviewed	IL3RB_HUMAN	Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)	CSF2RB IL3RB IL5RB	Homo sapiens (Human)	897	FUNCTION: Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}.		cellular response to interleukin-3 [GO:0036016]; cytokine-mediated signaling pathway [GO:0019221]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; immunoglobulin mediated immune response [GO:0016064]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-5-mediated signaling pathway [GO:0038043]; positive regulation of leukocyte proliferation [GO:0070665]; receptor signaling pathway via JAK-STAT [GO:0007259]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]	external side of plasma membrane [GO:0009897]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; plasma membrane [GO:0005886]	coreceptor activity [GO:0015026]; cytokine receptor activity [GO:0004896]; signaling receptor activity [GO:0038023]	external side of plasma membrane [GO:0009897]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; plasma membrane [GO:0005886]; coreceptor activity [GO:0015026]; cytokine receptor activity [GO:0004896]; signaling receptor activity [GO:0038023]; cellular response to interleukin-3 [GO:0036016]; cytokine-mediated signaling pathway [GO:0019221]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; immunoglobulin mediated immune response [GO:0016064]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-5-mediated signaling pathway [GO:0038043]; positive regulation of leukocyte proliferation [GO:0070665]; receptor signaling pathway via JAK-STAT [GO:0007259]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P32929	reviewed	CGL_HUMAN	Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2)	CTH	Homo sapiens (Human)	405	FUNCTION: Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (PubMed:10212249, PubMed:19261609, PubMed:19961860, PubMed:18476726). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione (PubMed:18476726). Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce the endogenous gaseous signaling molecule hydrogen sulfide (H2S) (PubMed:10212249, PubMed:19261609, PubMed:19961860, PubMed:19019829). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, also two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia (which is a risk factor for cardiovascular disease, diabetes, and Alzheimer's disease) (PubMed:19261609). Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively (PubMed:19261609). Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (PubMed:22169477). By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (Probable) (PubMed:29254196). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity). {ECO:0000250|UniProtKB:P18757, ECO:0000250|UniProtKB:Q8VCN5, ECO:0000269|PubMed:10212249, ECO:0000269|PubMed:18476726, ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:19961860, ECO:0000269|PubMed:22169477, ECO:0000269|PubMed:29254196, ECO:0000303|PubMed:18476726, ECO:0000305|PubMed:18476726, ECO:0000305|PubMed:19019829}.		cellular response to leukemia inhibitory factor [GO:1990830]; cysteine biosynthetic process [GO:0019344]; cysteine biosynthetic process via cystathionine [GO:0019343]; cysteine metabolic process [GO:0006534]; endoplasmic reticulum unfolded protein response [GO:0030968]; hydrogen sulfide biosynthetic process [GO:0070814]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic signaling pathway [GO:2001234]; positive regulation of aortic smooth muscle cell differentiation [GO:1904831]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein homotetramerization [GO:0051289]; protein sulfhydration [GO:0044524]; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine [GO:0018272]; transsulfuration [GO:0019346]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	calmodulin binding [GO:0005516]; cystathionine gamma-lyase activity [GO:0004123]; homocysteine desulfhydrase activity [GO:0047982]; identical protein binding [GO:0042802]; L-cysteine desulfhydrase activity [GO:0080146]; L-cystine L-cysteine-lyase (deaminating) [GO:0044540]; pyridoxal phosphate binding [GO:0030170]; selenocystathionine gamma-lyase activity [GO:0098606]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; calmodulin binding [GO:0005516]; cystathionine gamma-lyase activity [GO:0004123]; homocysteine desulfhydrase activity [GO:0047982]; identical protein binding [GO:0042802]; L-cysteine desulfhydrase activity [GO:0080146]; L-cystine L-cysteine-lyase (deaminating) [GO:0044540]; pyridoxal phosphate binding [GO:0030170]; selenocystathionine gamma-lyase activity [GO:0098606]; cellular response to leukemia inhibitory factor [GO:1990830]; cysteine biosynthetic process [GO:0019344]; cysteine biosynthetic process via cystathionine [GO:0019343]; cysteine metabolic process [GO:0006534]; endoplasmic reticulum unfolded protein response [GO:0030968]; hydrogen sulfide biosynthetic process [GO:0070814]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic signaling pathway [GO:2001234]; positive regulation of aortic smooth muscle cell differentiation [GO:1904831]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein homotetramerization [GO:0051289]; protein sulfhydration [GO:0044524]; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine [GO:0018272]; transsulfuration [GO:0019346]	SUBCELLULAR LOCATION: Cytoplasm.
P32942	reviewed	ICAM3_HUMAN	Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50)	ICAM3	Homo sapiens (Human)	547	FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000269|PubMed:1448173, ECO:0000269|PubMed:23775590}.		cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; phagocytosis [GO:0006909]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]; signaling receptor binding [GO:0005102]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; signaling receptor binding [GO:0005102]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; phagocytosis [GO:0006909]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P32969	reviewed	RL9_HUMAN	Large ribosomal subunit protein uL6 (60S ribosomal protein L9)	RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9	Homo sapiens (Human)	192	FUNCTION: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; ribosome [GO:0005840]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; ribosome [GO:0005840]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P32970	reviewed	CD70_HUMAN	CD70 antigen (CD27 ligand) (CD27-L) (Tumor necrosis factor ligand superfamily member 7) (CD antigen CD70)	CD70 CD27L CD27LG TNFSF7	Homo sapiens (Human)	193	FUNCTION: Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. {ECO:0000269|PubMed:28011863, ECO:0000269|PubMed:28011864, ECO:0000269|PubMed:8120384}.		B cell mediated immunity [GO:0019724]; B cell proliferation [GO:0042100]; cell-cell signaling [GO:0007267]; extrinsic apoptotic signaling pathway [GO:0097191]; positive regulation of T cell proliferation [GO:0042102]; signal transduction [GO:0007165]; T cell mediated immunity [GO:0002456]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; protease binding [GO:0002020]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; protease binding [GO:0002020]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; B cell mediated immunity [GO:0019724]; B cell proliferation [GO:0042100]; cell-cell signaling [GO:0007267]; extrinsic apoptotic signaling pathway [GO:0097191]; positive regulation of T cell proliferation [GO:0042102]; signal transduction [GO:0007165]; T cell mediated immunity [GO:0002456]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8120384}; Single-pass type II membrane protein {ECO:0000255}.
P32971	reviewed	TNFL8_HUMAN	Tumor necrosis factor ligand superfamily member 8 (CD30 ligand) (CD30-L) (CD antigen CD153)	TNFSF8 CD30L CD30LG	Homo sapiens (Human)	234	FUNCTION: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.		CD8-positive, alpha-beta T cell differentiation [GO:0043374]; cell-cell signaling [GO:0007267]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of T cell proliferation [GO:0042129]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; CD8-positive, alpha-beta T cell differentiation [GO:0043374]; cell-cell signaling [GO:0007267]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of T cell proliferation [GO:0042129]	SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
P33032	reviewed	MC5R_HUMAN	Melanocortin receptor 5 (MC5-R) (MC-2)	MC5R	Homo sapiens (Human)	325	FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; regulation of metabolic process [GO:0019222]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	hormone binding [GO:0042562]; melanocortin receptor activity [GO:0004977]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; hormone binding [GO:0042562]; melanocortin receptor activity [GO:0004977]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; regulation of metabolic process [GO:0019222]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P33076	reviewed	C2TA_HUMAN	MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1)	CIITA MHC2TA	Homo sapiens (Human)	1130	FUNCTION: Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:8402893, PubMed:7749984, PubMed:17493635, PubMed:16600381). Does not bind DNA (PubMed:8402893, PubMed:7749984, PubMed:17493635, PubMed:16600381). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:17493635, PubMed:16600381). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:8402893, PubMed:7749984, PubMed:17493635, PubMed:16600381). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:24036077, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:7749984, ECO:0000269|PubMed:8402893}.; FUNCTION: [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression. {ECO:0000269|PubMed:12919287}.		immune response [GO:0006955]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral entry into host cell [GO:0046597]; phosphorylation [GO:0016310]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to antibiotic [GO:0046677]; response to type II interferon [GO:0034341]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; PML body [GO:0016605]	acyltransferase activity [GO:0016746]; ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; GTP binding [GO:0005525]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; PML body [GO:0016605]; acyltransferase activity [GO:0016746]; ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; GTP binding [GO:0005525]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; immune response [GO:0006955]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral entry into host cell [GO:0046597]; phosphorylation [GO:0016310]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to antibiotic [GO:0046677]; response to type II interferon [GO:0034341]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:23007646}. Nucleus, PML body {ECO:0000269|PubMed:23007646}. Note=Recruited to PML body by PML. {ECO:0000269|PubMed:23007646}.
P33121	reviewed	ACSL1_HUMAN	Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24)	ACSL1 FACL1 FACL2 LACS LACS1 LACS2	Homo sapiens (Human)	698	FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity). {ECO:0000250|UniProtKB:P18163, ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site. {ECO:0000305}.	adiponectin-activated signaling pathway [GO:0033211]; fatty acid transport [GO:0015908]; lipid biosynthetic process [GO:0008610]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of long-chain fatty acid import across plasma membrane [GO:0010747]; response to nutrient [GO:0007584]; response to oleic acid [GO:0034201]; response to organic cyclic compound [GO:0014070]; triglyceride biosynthetic process [GO:0019432]; very long-chain fatty acid metabolic process [GO:0000038]; xenobiotic catabolic process [GO:0042178]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]	arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oleoyl-CoA ligase activity [GO:0090434]; phytanate-CoA ligase activity [GO:0050197]; pristanate-CoA ligase activity [GO:0070251]; protein serine/threonine kinase activator activity [GO:0043539]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oleoyl-CoA ligase activity [GO:0090434]; phytanate-CoA ligase activity [GO:0050197]; pristanate-CoA ligase activity [GO:0070251]; protein serine/threonine kinase activator activity [GO:0043539]; adiponectin-activated signaling pathway [GO:0033211]; fatty acid transport [GO:0015908]; lipid biosynthetic process [GO:0008610]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of long-chain fatty acid import across plasma membrane [GO:0010747]; response to nutrient [GO:0007584]; response to oleic acid [GO:0034201]; response to organic cyclic compound [GO:0014070]; triglyceride biosynthetic process [GO:0019432]; very long-chain fatty acid metabolic process [GO:0000038]; xenobiotic catabolic process [GO:0042178]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24269233}; Single-pass type III membrane protein {ECO:0000250}.
P33151	reviewed	CADH5_HUMAN	Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)	CDH5	Homo sapiens (Human)	784	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120). Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120). {ECO:0000250|UniProtKB:P55284, ECO:0000250|UniProtKB:Q8AYD0, ECO:0000269|PubMed:10861224, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21269602}.		adherens junction organization [GO:0034332]; bicellular tight junction assembly [GO:0070830]; blood vessel endothelial cell migration [GO:0043534]; blood vessel maturation [GO:0001955]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; negative regulation of microtubule polymerization [GO:0031115]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell migration [GO:0030335]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of gene expression [GO:0010628]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to bicellular tight junction [GO:1902396]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein phosphorylation [GO:0001932]; regulation of vascular permeability [GO:0043114]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculature development [GO:0001944]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	beta-catenin binding [GO:0008013]; BMP receptor binding [GO:0070700]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; fibrinogen binding [GO:0070051]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; vascular endothelial growth factor receptor 2 binding [GO:0043184]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; BMP receptor binding [GO:0070700]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; fibrinogen binding [GO:0070051]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; adherens junction organization [GO:0034332]; bicellular tight junction assembly [GO:0070830]; blood vessel endothelial cell migration [GO:0043534]; blood vessel maturation [GO:0001955]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; negative regulation of microtubule polymerization [GO:0031115]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell migration [GO:0030335]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of gene expression [GO:0010628]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to bicellular tight junction [GO:1902396]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein phosphorylation [GO:0001932]; regulation of vascular permeability [GO:0043114]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculature development [GO:0001944]	SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21183689}. Cell membrane {ECO:0000269|PubMed:15980433, ECO:0000305|PubMed:20332120}; Single-pass type I membrane protein {ECO:0000305|PubMed:20332120}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. {ECO:0000269|PubMed:20332120}.
P33176	reviewed	KINH_HUMAN	Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC)	KIF5B KNS KNS1	Homo sapiens (Human)	963	FUNCTION: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}.		anterograde axonal protein transport [GO:0099641]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; anterograde neuronal dense core vesicle transport [GO:1990048]; axon guidance [GO:0007411]; cellular response to type II interferon [GO:0071346]; centrosome localization [GO:0051642]; cytoplasm organization [GO:0007028]; lysosome localization [GO:0032418]; microtubule-based movement [GO:0007018]; mitochondrion transport along microtubule [GO:0047497]; mitocytosis [GO:0160040]; natural killer cell mediated cytotoxicity [GO:0042267]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of membrane potential [GO:0042391]; retrograde neuronal dense core vesicle transport [GO:1990049]; stress granule disassembly [GO:0035617]; synaptic vesicle transport [GO:0048489]; vesicle transport along microtubule [GO:0047496]	axon cytoplasm [GO:1904115]; centriolar satellite [GO:0034451]; ciliary rootlet [GO:0035253]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; vesicle [GO:0031982]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein-containing complex binding [GO:0044877]	axon cytoplasm [GO:1904115]; centriolar satellite [GO:0034451]; ciliary rootlet [GO:0035253]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; vesicle [GO:0031982]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein-containing complex binding [GO:0044877]; anterograde axonal protein transport [GO:0099641]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; anterograde neuronal dense core vesicle transport [GO:1990048]; axon guidance [GO:0007411]; cellular response to type II interferon [GO:0071346]; centrosome localization [GO:0051642]; cytoplasm organization [GO:0007028]; lysosome localization [GO:0032418]; microtubule-based movement [GO:0007018]; mitochondrion transport along microtubule [GO:0047497]; mitocytosis [GO:0160040]; natural killer cell mediated cytotoxicity [GO:0042267]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of membrane potential [GO:0042391]; retrograde neuronal dense core vesicle transport [GO:1990049]; stress granule disassembly [GO:0035617]; synaptic vesicle transport [GO:0048489]; vesicle transport along microtubule [GO:0047496]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2PQA9}. Cytolytic granule membrane {ECO:0000269|PubMed:24088571}. Lysosome membrane {ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571}; Peripheral membrane protein {ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}; Cytoplasmic side {ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250|UniProtKB:Q2PQA9}.
P33240	reviewed	CSTF2_HUMAN	Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64)	CSTF2	Homo sapiens (Human)	577	FUNCTION: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250, ECO:0000269|PubMed:9199325}.		cellular response to nerve growth factor stimulus [GO:1990090]; mRNA 3'-end processing [GO:0031124]	cleavage body [GO:0071920]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cleavage body [GO:0071920]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; cellular response to nerve growth factor stimulus [GO:1990090]; mRNA 3'-end processing [GO:0031124]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11598190}. Note=Localized with DDX1 in cleavage bodies.
P33241	reviewed	LSP1_HUMAN	Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34)	LSP1 WP34	Homo sapiens (Human)	339	FUNCTION: May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}.		cellular defense response [GO:0006968]; cellular response to interleukin-7 [GO:0098761]; chemotaxis [GO:0006935]; signal transduction [GO:0007165]	actin cytoskeleton [GO:0015629]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	actin binding [GO:0003779]	actin cytoskeleton [GO:0015629]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; cellular defense response [GO:0006968]; cellular response to interleukin-7 [GO:0098761]; chemotaxis [GO:0006935]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
P33260	reviewed	CP2CI_HUMAN	Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (Cytochrome P450-6b/29c)	CYP2C18	Homo sapiens (Human)	490	FUNCTION: A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). {ECO:0000269|PubMed:11093772}.		epoxygenase P450 pathway [GO:0019373]; linoleic acid metabolic process [GO:0043651]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; linoleic acid epoxygenase activity [GO:0071614]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; retinoic acid 4-hydroxylase activity [GO:0008401]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; linoleic acid epoxygenase activity [GO:0071614]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; retinoic acid 4-hydroxylase activity [GO:0008401]; epoxygenase P450 pathway [GO:0019373]; linoleic acid metabolic process [GO:0043651]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11093772}; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:11093772}; Peripheral membrane protein.
P33261	reviewed	CP2CJ_HUMAN	Cytochrome P450 2C19 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase)	CYP2C19	Homo sapiens (Human)	490	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768). Catalyzes the epoxidation of double bonds of PUFA (PubMed:20972997, PubMed:19965576). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed:23959307). {ECO:0000269|PubMed:11950794, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20972997, ECO:0000269|PubMed:23959307}.		epoxygenase P450 pathway [GO:0019373]; heterocycle metabolic process [GO:0046483]; long-chain fatty acid metabolic process [GO:0001676]; monoterpenoid metabolic process [GO:0016098]; omega-hydroxylase P450 pathway [GO:0097267]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	(R)-limonene 6-monooxygenase activity [GO:0052741]; (S)-limonene 6-monooxygenase activity [GO:0018675]; (S)-limonene 7-monooxygenase activity [GO:0018676]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-1 hydroxylase activity [GO:0120319]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; steroid hydroxylase activity [GO:0008395]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; (R)-limonene 6-monooxygenase activity [GO:0052741]; (S)-limonene 6-monooxygenase activity [GO:0018675]; (S)-limonene 7-monooxygenase activity [GO:0018676]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-1 hydroxylase activity [GO:0120319]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; steroid hydroxylase activity [GO:0008395]; epoxygenase P450 pathway [GO:0019373]; heterocycle metabolic process [GO:0046483]; long-chain fatty acid metabolic process [GO:0001676]; monoterpenoid metabolic process [GO:0016098]; omega-hydroxylase P450 pathway [GO:0097267]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
P33316	reviewed	DUT_HUMAN	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)	DUT	Homo sapiens (Human)	252	FUNCTION: Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:P70583, ECO:0000250|UniProtKB:Q9CQ43, ECO:0000269|PubMed:17880943, ECO:0000269|PubMed:8631816, ECO:0000269|PubMed:8805593}.	MISCELLANEOUS: Each trimer binds three substrate molecules. The ligands are bound between subunits, and for each substrate molecule, residues from adjacent subunits contribute to the binding interactions.; MISCELLANEOUS: [Isoform 2]: Major isoform. {ECO:0000305}.	DNA replication [GO:0006260]; dTMP biosynthetic process [GO:0006231]; dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]; liver development [GO:0001889]; nucleobase-containing compound metabolic process [GO:0006139]; regulation of protein-containing complex assembly [GO:0043254]; response to organic cyclic compound [GO:0014070]	extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	dUTP diphosphatase activity [GO:0004170]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; peroxisome proliferator activated receptor binding [GO:0042975]; pyrimidine deoxyribonucleotide binding [GO:0032556]; RNA binding [GO:0003723]; signaling receptor inhibitor activity [GO:0030547]	extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; dUTP diphosphatase activity [GO:0004170]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; peroxisome proliferator activated receptor binding [GO:0042975]; pyrimidine deoxyribonucleotide binding [GO:0032556]; RNA binding [GO:0003723]; signaling receptor inhibitor activity [GO:0030547]; DNA replication [GO:0006260]; dTMP biosynthetic process [GO:0006231]; dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]; liver development [GO:0001889]; nucleobase-containing compound metabolic process [GO:0006139]; regulation of protein-containing complex assembly [GO:0043254]; response to organic cyclic compound [GO:0014070]	SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:8631816, ECO:0000269|PubMed:9070952}.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion {ECO:0000269|PubMed:8631816, ECO:0000269|PubMed:9070952}.
P33402	reviewed	GCYA2_HUMAN	Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2)	GUCY1A2 GUC1A2 GUCSA2	Homo sapiens (Human)	732	FUNCTION: Has guanylyl cyclase on binding to the beta-1 subunit.; FUNCTION: Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.	MISCELLANEOUS: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.	cGMP-mediated signaling [GO:0019934]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; response to oxygen levels [GO:0070482]; signal transduction [GO:0007165]	cytosol [GO:0005829]; guanylate cyclase complex, soluble [GO:0008074]	GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]	cytosol [GO:0005829]; guanylate cyclase complex, soluble [GO:0008074]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; cGMP-mediated signaling [GO:0019934]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; response to oxygen levels [GO:0070482]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm.
P33527	reviewed	MRP1_HUMAN	Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter)	ABCC1 MRP MRP1	Homo sapiens (Human)	1531	FUNCTION: Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). {ECO:0000250|UniProtKB:O35379, ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:36070769, ECO:0000269|PubMed:7961706, ECO:0000269|PubMed:9281595}.		carboxylic acid transmembrane transport [GO:1905039]; cell chemotaxis [GO:0060326]; cellular response to amyloid-beta [GO:1904646]; cellular response to oxidative stress [GO:0034599]; cobalamin transport [GO:0015889]; cyclic nucleotide transport [GO:0070729]; export across plasma membrane [GO:0140115]; glutathione transmembrane transport [GO:0034775]; heme catabolic process [GO:0042167]; leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; phospholipid translocation [GO:0045332]; positive regulation of inflammatory response [GO:0050729]; response to xenobiotic stimulus [GO:0009410]; sphingolipid translocation [GO:0099039]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type vitamin B12 transporter activity [GO:0015420]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carboxylic acid transmembrane transporter activity [GO:0046943]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type vitamin B12 transporter activity [GO:0015420]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carboxylic acid transmembrane transporter activity [GO:0046943]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; xenobiotic transmembrane transporter activity [GO:0042910]; carboxylic acid transmembrane transport [GO:1905039]; cell chemotaxis [GO:0060326]; cellular response to amyloid-beta [GO:1904646]; cellular response to oxidative stress [GO:0034599]; cobalamin transport [GO:0015889]; cyclic nucleotide transport [GO:0070729]; export across plasma membrane [GO:0140115]; glutathione transmembrane transport [GO:0034775]; heme catabolic process [GO:0042167]; leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; phospholipid translocation [GO:0045332]; positive regulation of inflammatory response [GO:0050729]; response to xenobiotic stimulus [GO:0009410]; sphingolipid translocation [GO:0099039]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:31273342}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:16230346}.
P33681	reviewed	CD80_HUMAN	T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)	CD80 CD28LG CD28LG1 LAB7	Homo sapiens (Human)	288	FUNCTION: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. {ECO:0000269|PubMed:10583602}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus subgroup B. {ECO:0000269|PubMed:16920215}.	MISCELLANEOUS: [Isoform 2]: Soluble isoform. Expressed in unstimulated B-cells and monocytes, but not T-cells. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Soluble isoform. Expressed in T-cells activated by ConA, non-activated monocytes and monocytes activated with IFN-c. {ECO:0000305}.	cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; negative regulation of T cell mediated immunity [GO:0002710]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of signal transduction [GO:0009967]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]	coreceptor activity [GO:0015026]; receptor ligand activity [GO:0048018]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]; coreceptor activity [GO:0015026]; receptor ligand activity [GO:0048018]; virus receptor activity [GO:0001618]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; negative regulation of T cell mediated immunity [GO:0002710]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of signal transduction [GO:0009967]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P33763	reviewed	S10A5_HUMAN	Protein S100-A5 (Protein S-100D) (S100 calcium-binding protein A5)	S100A5 S100D	Homo sapiens (Human)	92	FUNCTION: Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites. {ECO:0000269|PubMed:10882717}.			neuronal cell body [GO:0043025]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; copper ion binding [GO:0005507]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	neuronal cell body [GO:0043025]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; copper ion binding [GO:0005507]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	
P33764	reviewed	S10A3_HUMAN	Protein S100-A3 (Protein S-100E) (S100 calcium-binding protein A3)	S100A3 S100E	Homo sapiens (Human)	101	FUNCTION: Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. {ECO:0000269|PubMed:18083705}.			cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18083705}.
P33778	reviewed	H2B1B_HUMAN	Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f)	H2BC3 H2BFF HIST1H2BB	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		nucleosome assembly [GO:0006334]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P33897	reviewed	ABCD1_HUMAN	ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP)	ABCD1 ALD	Homo sapiens (Human)	745	FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:11248239, PubMed:15682271, PubMed:16946495, PubMed:18757502, PubMed:21145416, PubMed:23671276, PubMed:29397936, PubMed:33500543). Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (PubMed:33500543, PubMed:29397936). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:23671276, PubMed:21145416). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity). {ECO:0000250|UniProtKB:P48410, ECO:0000269|PubMed:11248239, ECO:0000269|PubMed:15682271, ECO:0000269|PubMed:16946495, ECO:0000269|PubMed:18757502, ECO:0000269|PubMed:21145416, ECO:0000269|PubMed:23671276, ECO:0000269|PubMed:29397936, ECO:0000269|PubMed:33500543}.		alpha-linolenic acid metabolic process [GO:0036109]; fatty acid beta-oxidation [GO:0006635]; fatty acid elongation [GO:0030497]; fatty acid homeostasis [GO:0055089]; linoleic acid metabolic process [GO:0043651]; long-chain fatty acid catabolic process [GO:0042758]; long-chain fatty acid import into peroxisome [GO:0015910]; myelin maintenance [GO:0043217]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection maintenance [GO:1990535]; peroxisomal membrane transport [GO:0015919]; peroxisome organization [GO:0007031]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of unsaturated fatty acid biosynthetic process [GO:2001280]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of mitochondrial depolarization [GO:0051900]; regulation of oxidative phosphorylation [GO:0002082]; sterol homeostasis [GO:0055092]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038]; very long-chain fatty-acyl-CoA catabolic process [GO:0036113]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	ABC-type fatty-acyl-CoA transporter activity [GO:0015607]; acyl-CoA hydrolase activity [GO:0047617]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; long-chain fatty acid transporter activity [GO:0005324]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; ABC-type fatty-acyl-CoA transporter activity [GO:0015607]; acyl-CoA hydrolase activity [GO:0047617]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; long-chain fatty acid transporter activity [GO:0005324]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; alpha-linolenic acid metabolic process [GO:0036109]; fatty acid beta-oxidation [GO:0006635]; fatty acid elongation [GO:0030497]; fatty acid homeostasis [GO:0055089]; linoleic acid metabolic process [GO:0043651]; long-chain fatty acid catabolic process [GO:0042758]; long-chain fatty acid import into peroxisome [GO:0015910]; myelin maintenance [GO:0043217]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection maintenance [GO:1990535]; peroxisomal membrane transport [GO:0015919]; peroxisome organization [GO:0007031]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of unsaturated fatty acid biosynthetic process [GO:2001280]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of mitochondrial depolarization [GO:0051900]; regulation of oxidative phosphorylation [GO:0002082]; sterol homeostasis [GO:0055092]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038]; very long-chain fatty-acyl-CoA catabolic process [GO:0036113]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:10777694, ECO:0000269|PubMed:16946495, ECO:0000269|PubMed:17609205, ECO:0000269|PubMed:18757502, ECO:0000269|PubMed:29397936}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:16946495}; Multi-pass membrane protein. Lysosome membrane {ECO:0000269|PubMed:16946495}; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16946495}; Multi-pass membrane protein.
P33908	reviewed	MA1A1_HUMAN	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA)	MAN1A1	Homo sapiens (Human)	653	FUNCTION: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).		carbohydrate metabolic process [GO:0005975]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; protein targeting to ER [GO:0045047]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; mannosidase activity [GO:0015923]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; mannosidase activity [GO:0015923]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]; carbohydrate metabolic process [GO:0005975]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; protein targeting to ER [GO:0045047]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein.
P33947	reviewed	ERD22_HUMAN	ER lumen protein-retaining receptor 2 (ERD2-like protein 1) (ELP-1) (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2)	KDELR2 ERD2.2	Homo sapiens (Human)	212	FUNCTION: Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi (PubMed:1325562, PubMed:18086916, PubMed:33053334). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity). {ECO:0000250|UniProtKB:Q5ZKX9, ECO:0000269|PubMed:1325562, ECO:0000269|PubMed:18086916, ECO:0000269|PubMed:33053334}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133]	ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046]	cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133]; ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:1325562, ECO:0000269|PubMed:18086916}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Golgi apparatus membrane {ECO:0000269|PubMed:1325562, ECO:0000269|PubMed:18086916}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:18086916}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. {ECO:0000269|PubMed:1325562, ECO:0000305|PubMed:18086916}.
P33981	reviewed	TTK_HUMAN	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)	TTK MPS1 MPS1L1	Homo sapiens (Human)	857	FUNCTION: Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:29162720}.		chromosome segregation [GO:0007059]; female meiosis chromosome segregation [GO:0016321]; meiotic spindle assembly checkpoint signaling [GO:0033316]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; phosphorylation [GO:0016310]; positive regulation of cell population proliferation [GO:0008284]; protein localization to kinetochore [GO:0034501]; protein localization to meiotic spindle midzone [GO:1903096]; spindle organization [GO:0007051]	cytoplasm [GO:0005737]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinetochore binding [GO:0043515]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinetochore binding [GO:0043515]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; chromosome segregation [GO:0007059]; female meiosis chromosome segregation [GO:0016321]; meiotic spindle assembly checkpoint signaling [GO:0033316]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; phosphorylation [GO:0016310]; positive regulation of cell population proliferation [GO:0008284]; protein localization to kinetochore [GO:0034501]; protein localization to meiotic spindle midzone [GO:1903096]; spindle organization [GO:0007051]	
P33991	reviewed	MCM4_HUMAN	DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)	MCM4 CDC21	Homo sapiens (Human)	863	FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:16899510, PubMed:25661590, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425, PubMed:16899510, PubMed:25661590, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.	MISCELLANEOUS: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex. {ECO:0000250|UniProtKB:P49717}.	DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; regulation of DNA-templated DNA replication initiation [GO:0030174]	chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]	chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; regulation of DNA-templated DNA replication initiation [GO:0030174]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000305|PubMed:35585232}.
P33992	reviewed	MCM5_HUMAN	DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46)	MCM5 CDC46	Homo sapiens (Human)	734	FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:16899510). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}.	MISCELLANEOUS: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex.	cell cycle [GO:0007049]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; regulation of DNA-templated DNA replication initiation [GO:0030174]	chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA replication origin binding [GO:0003688]; helicase activity [GO:0004386]; single-stranded DNA binding [GO:0003697]	chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA replication origin binding [GO:0003688]; helicase activity [GO:0004386]; single-stranded DNA binding [GO:0003697]; cell cycle [GO:0007049]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; regulation of DNA-templated DNA replication initiation [GO:0030174]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000305|PubMed:35585232}.
P33993	reviewed	MCM7_HUMAN	DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)	MCM7 CDC47 MCM2	Homo sapiens (Human)	719	FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:25661590, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.	MISCELLANEOUS: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex. {ECO:0000250|UniProtKB:Q61881}.	cell cycle [GO:0007049]; cell population proliferation [GO:0008283]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage response [GO:0006974]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of phosphorylation [GO:0042325]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; cytosol [GO:0005829]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; cytosol [GO:0005829]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]; cell cycle [GO:0007049]; cell population proliferation [GO:0008283]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage response [GO:0006974]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of phosphorylation [GO:0042325]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000305|PubMed:35585232}.
P34059	reviewed	GALNS_HUMAN	N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (GalN6S) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase)	GALNS	Homo sapiens (Human)	522				azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]	arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943]; N-acetylgalactosamine-6-sulfatase activity [GO:0043890]; sulfuric ester hydrolase activity [GO:0008484]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943]; N-acetylgalactosamine-6-sulfatase activity [GO:0043890]; sulfuric ester hydrolase activity [GO:0008484]	SUBCELLULAR LOCATION: Lysosome.
P34096	reviewed	RNAS4_HUMAN	Ribonuclease 4 (RNase 4) (EC 3.1.27.-)	RNASE4 RNS4	Homo sapiens (Human)	147	FUNCTION: Cleaves preferentially after uridine bases (PubMed:3467790). Has antimicrobial activity against uropathogenic E.coli (UPEC) (PubMed:33818125). Probably contributes to urinary tract sterility (PubMed:33818125). {ECO:0000269|PubMed:33818125, ECO:0000269|PubMed:3467790}.		antibacterial humoral response [GO:0019731]; defense response to Gram-positive bacterium [GO:0050830]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540]; antibacterial humoral response [GO:0019731]; defense response to Gram-positive bacterium [GO:0050830]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:33818125}. Note=Detected in urine. {ECO:0000269|PubMed:33818125}.
P34130	reviewed	NTF4_HUMAN	Neurotrophin-4 (NT-4) (Neurotrophin-5) (NT-5) (Neutrophic factor 4)	NTF4 NTF5	Homo sapiens (Human)	210	FUNCTION: Target-derived survival factor for peripheral sensory sympathetic neurons.		adult locomotory behavior [GO:0008344]; epidermis development [GO:0008544]; ganglion mother cell fate determination [GO:0007402]; innervation [GO:0060384]; long-term memory [GO:0007616]; mechanoreceptor differentiation [GO:0042490]; memory [GO:0007613]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; neuron projection morphogenesis [GO:0048812]; peripheral nervous system development [GO:0007422]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of neuron differentiation [GO:0045664]; sensory organ boundary specification [GO:0008052]; taste bud development [GO:0061193]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; synaptic vesicle [GO:0008021]	growth factor activity [GO:0008083]; nerve growth factor receptor binding [GO:0005163]	axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; synaptic vesicle [GO:0008021]; growth factor activity [GO:0008083]; nerve growth factor receptor binding [GO:0005163]; adult locomotory behavior [GO:0008344]; epidermis development [GO:0008544]; ganglion mother cell fate determination [GO:0007402]; innervation [GO:0060384]; long-term memory [GO:0007616]; mechanoreceptor differentiation [GO:0042490]; memory [GO:0007613]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; neuron projection morphogenesis [GO:0048812]; peripheral nervous system development [GO:0007422]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of neuron differentiation [GO:0045664]; sensory organ boundary specification [GO:0008052]; taste bud development [GO:0061193]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Secreted.
P34741	reviewed	SDC2_HUMAN	Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362)	SDC2 HSPG1	Homo sapiens (Human)	201	FUNCTION: Cell surface proteoglycan which regulates dendritic arbor morphogenesis. {ECO:0000250|UniProtKB:P43407}.		cell migration [GO:0016477]; dendrite morphogenesis [GO:0048813]; regulation of dendrite morphogenesis [GO:0048814]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; cell migration [GO:0016477]; dendrite morphogenesis [GO:0048813]; regulation of dendrite morphogenesis [GO:0048814]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P34810	reviewed	CD68_HUMAN	Macrosialin (Gp110) (CD antigen CD68)	CD68	Homo sapiens (Human)	354	FUNCTION: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.		cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient levels [GO:0031669]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; establishment of protein localization to organelle [GO:0072594]; inflammatory response to antigenic stimulus [GO:0002437]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]	azurophil granule membrane [GO:0035577]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]		azurophil granule membrane [GO:0035577]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient levels [GO:0031669]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; establishment of protein localization to organelle [GO:0072594]; inflammatory response to antigenic stimulus [GO:0002437]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]	SUBCELLULAR LOCATION: [Isoform Short]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
P34896	reviewed	GLYC_HUMAN	Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)	SHMT1	Homo sapiens (Human)	483	FUNCTION: Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160). {ECO:0000269|PubMed:24698160, ECO:0000269|PubMed:8505317}.	MISCELLANEOUS: In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one. {ECO:0000305}.	cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to tetrahydrofolate [GO:1904482]; dTMP biosynthetic process [GO:0006231]; folic acid metabolic process [GO:0046655]; glycine biosynthetic process from serine [GO:0019264]; glycine metabolic process [GO:0006544]; L-serine catabolic process [GO:0006565]; L-serine metabolic process [GO:0006563]; negative regulation of translation [GO:0017148]; protein homotetramerization [GO:0051289]; purine nucleobase biosynthetic process [GO:0009113]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	glycine hydroxymethyltransferase activity [GO:0004372]; identical protein binding [GO:0042802]; mRNA 5'-UTR binding [GO:0048027]; mRNA regulatory element binding translation repressor activity [GO:0000900]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]; small molecule binding [GO:0036094]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; glycine hydroxymethyltransferase activity [GO:0004372]; identical protein binding [GO:0042802]; mRNA 5'-UTR binding [GO:0048027]; mRNA regulatory element binding translation repressor activity [GO:0000900]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]; small molecule binding [GO:0036094]; zinc ion binding [GO:0008270]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to tetrahydrofolate [GO:1904482]; dTMP biosynthetic process [GO:0006231]; folic acid metabolic process [GO:0046655]; glycine biosynthetic process from serine [GO:0019264]; glycine metabolic process [GO:0006544]; L-serine catabolic process [GO:0006565]; L-serine metabolic process [GO:0006563]; negative regulation of translation [GO:0017148]; protein homotetramerization [GO:0051289]; purine nucleobase biosynthetic process [GO:0009113]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	SUBCELLULAR LOCATION: Cytoplasm.
P34897	reviewed	GLYM_HUMAN	Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)	SHMT2	Homo sapiens (Human)	504	FUNCTION: Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:29364879, PubMed:33015733, PubMed:25619277, PubMed:33015733). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29452640, PubMed:29364879). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25619277, ECO:0000269|PubMed:29364879, ECO:0000269|PubMed:29452640, ECO:0000269|PubMed:33015733}.	MISCELLANEOUS: In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.	folic acid metabolic process [GO:0046655]; glycine biosynthetic process from serine [GO:0019264]; glycine metabolic process [GO:0006544]; L-serine catabolic process [GO:0006565]; L-serine metabolic process [GO:0006563]; one-carbon metabolic process [GO:0006730]; protein homotetramerization [GO:0051289]; protein K63-linked deubiquitination [GO:0070536]; protein tetramerization [GO:0051262]; purine nucleobase biosynthetic process [GO:0009113]; regulation of aerobic respiration [GO:1903715]; regulation of mitochondrial translation [GO:0070129]; regulation of oxidative phosphorylation [GO:0002082]; response to type I interferon [GO:0034340]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; glycine hydroxymethyltransferase activity [GO:0004372]; mRNA 5'-UTR binding [GO:0048027]; mRNA regulatory element binding translation repressor activity [GO:0000900]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]; zinc ion binding [GO:0008270]	BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; glycine hydroxymethyltransferase activity [GO:0004372]; mRNA 5'-UTR binding [GO:0048027]; mRNA regulatory element binding translation repressor activity [GO:0000900]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]; zinc ion binding [GO:0008270]; folic acid metabolic process [GO:0046655]; glycine biosynthetic process from serine [GO:0019264]; glycine metabolic process [GO:0006544]; L-serine catabolic process [GO:0006565]; L-serine metabolic process [GO:0006563]; one-carbon metabolic process [GO:0006730]; protein homotetramerization [GO:0051289]; protein K63-linked deubiquitination [GO:0070536]; protein tetramerization [GO:0051262]; purine nucleobase biosynthetic process [GO:0009113]; regulation of aerobic respiration [GO:1903715]; regulation of mitochondrial translation [GO:0070129]; regulation of oxidative phosphorylation [GO:0002082]; response to type I interferon [GO:0034340]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:24075985}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}. Mitochondrion inner membrane {ECO:0000269|PubMed:21876188}. Cytoplasm {ECO:0000269|PubMed:24075985}. Nucleus {ECO:0000269|PubMed:24075985}. Note=Mainly localizes in the mitochondrion. Also found in the cytoplasm and nucleus as part of the BRISC complex (PubMed:24075985). {ECO:0000269|PubMed:24075985}.
P34903	reviewed	GBRA3_HUMAN	Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3)	GABRA3	Homo sapiens (Human)	492	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. {ECO:0000269|PubMed:29053855}.		chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]	chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
P34910	reviewed	EVI2B_HUMAN	Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361)	EVI2B EVDB	Homo sapiens (Human)	448	FUNCTION: Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}.		myeloid cell development [GO:0061515]; negative regulation of apoptotic process [GO:0043066]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of neutrophil differentiation [GO:0045660]; regulation of cell cycle [GO:0051726]; regulation of stem cell division [GO:2000035]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; myeloid cell development [GO:0061515]; negative regulation of apoptotic process [GO:0043066]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of neutrophil differentiation [GO:0045660]; regulation of cell cycle [GO:0051726]; regulation of stem cell division [GO:2000035]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P34913	reviewed	HYES_HUMAN	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)]	EPHX2	Homo sapiens (Human)	555	FUNCTION: Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687, PubMed:21217101). {ECO:0000250|UniProtKB:P80299, ECO:0000269|PubMed:12574508, ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:12869654, ECO:0000269|PubMed:21217101, ECO:0000269|PubMed:22798687}.; FUNCTION: Bifunctional enzyme (PubMed:12574510). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510). Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (PubMed:22217705, PubMed:22387545). {ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545}.		cholesterol homeostasis [GO:0042632]; dephosphorylation [GO:0016311]; epoxide metabolic process [GO:0097176]; phospholipid dephosphorylation [GO:0046839]; positive regulation of gene expression [GO:0010628]; regulation of cholesterol metabolic process [GO:0090181]; response to toxic substance [GO:0009636]; stilbene catabolic process [GO:0046272]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity [GO:0033885]; epoxide hydrolase activity [GO:0004301]; lipid phosphatase activity [GO:0042577]; lysophosphatidic acid phosphatase activity [GO:0052642]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity [GO:0033885]; epoxide hydrolase activity [GO:0004301]; lipid phosphatase activity [GO:0042577]; lysophosphatidic acid phosphatase activity [GO:0052642]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]; cholesterol homeostasis [GO:0042632]; dephosphorylation [GO:0016311]; epoxide metabolic process [GO:0097176]; phospholipid dephosphorylation [GO:0046839]; positive regulation of gene expression [GO:0010628]; regulation of cholesterol metabolic process [GO:0090181]; response to toxic substance [GO:0009636]; stilbene catabolic process [GO:0046272]	SUBCELLULAR LOCATION: Cytoplasm. Peroxisome.
P34925	reviewed	RYK_HUMAN	Tyrosine-protein kinase RYK (EC 2.7.10.1)	RYK JTK5A	Homo sapiens (Human)	607	FUNCTION: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. {ECO:0000269|PubMed:15454084}.		axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cell proliferation in midbrain [GO:0033278]; chemorepulsion of dopaminergic neuron axon [GO:0036518]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; non-canonical Wnt signaling pathway [GO:0035567]; phosphorylation [GO:0016310]; planar cell polarity pathway involved in axon guidance [GO:1904938]; positive regulation of MAPK cascade [GO:0043410]; signal transduction [GO:0007165]; skeletal system morphogenesis [GO:0048705]; synapse assembly [GO:0007416]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]; frizzled binding [GO:0005109]; protein kinase activity [GO:0004672]; transmembrane signaling receptor activity [GO:0004888]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]; frizzled binding [GO:0005109]; protein kinase activity [GO:0004672]; transmembrane signaling receptor activity [GO:0004888]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cell proliferation in midbrain [GO:0033278]; chemorepulsion of dopaminergic neuron axon [GO:0036518]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; non-canonical Wnt signaling pathway [GO:0035567]; phosphorylation [GO:0016310]; planar cell polarity pathway involved in axon guidance [GO:1904938]; positive regulation of MAPK cascade [GO:0043410]; signal transduction [GO:0007165]; skeletal system morphogenesis [GO:0048705]; synapse assembly [GO:0007416]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. {ECO:0000250}.
P34931	reviewed	HS71L_HUMAN	Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom)	HSPA1L	Homo sapiens (Human)	641	FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}.		binding of sperm to zona pellucida [GO:0007339]; chaperone cofactor-dependent protein refolding [GO:0051085]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein refolding [GO:0042026]; response to unfolded protein [GO:0006986]	blood microparticle [GO:0072562]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; zona pellucida receptor complex [GO:0002199]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	blood microparticle [GO:0072562]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; zona pellucida receptor complex [GO:0002199]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; binding of sperm to zona pellucida [GO:0007339]; chaperone cofactor-dependent protein refolding [GO:0051085]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein refolding [GO:0042026]; response to unfolded protein [GO:0006986]	
P34932	reviewed	HSP74_HUMAN	Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2)	HSPA4 APG2	Homo sapiens (Human)	840			chaperone-mediated protein complex assembly [GO:0051131]; protein folding [GO:0006457]; protein insertion into mitochondrial outer membrane [GO:0045040]; response to unfolded protein [GO:0006986]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; chaperone-mediated protein complex assembly [GO:0051131]; protein folding [GO:0006457]; protein insertion into mitochondrial outer membrane [GO:0045040]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P34947	reviewed	GRK5_HUMAN	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5)	GRK5 GPRK5	Homo sapiens (Human)	590	FUNCTION: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro). {ECO:0000269|PubMed:19661922, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20038610, ECO:0000269|PubMed:20124405, ECO:0000269|PubMed:21728385}.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; apoptotic process [GO:0006915]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; protein autophosphorylation [GO:0046777]; regulation of cell cycle [GO:0051726]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of signal transduction [GO:0009966]; tachykinin receptor signaling pathway [GO:0007217]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; G protein-coupled receptor kinase activity [GO:0004703]; phospholipid binding [GO:0005543]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; G protein-coupled receptor kinase activity [GO:0004703]; phospholipid binding [GO:0005543]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein serine/threonine kinase activity [GO:0004674]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; apoptotic process [GO:0006915]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; protein autophosphorylation [GO:0046777]; regulation of cell cycle [GO:0051726]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of signal transduction [GO:0009966]; tachykinin receptor signaling pathway [GO:0007217]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion.
P34949	reviewed	MPI_HUMAN	Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI)	MPI PMI1	Homo sapiens (Human)	423	FUNCTION: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.		GDP-mannose biosynthetic process [GO:0009298]; mannose to fructose-6-phosphate metabolic process [GO:0061611]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	mannose-6-phosphate isomerase activity [GO:0004476]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mannose-6-phosphate isomerase activity [GO:0004476]; zinc ion binding [GO:0008270]; GDP-mannose biosynthetic process [GO:0009298]; mannose to fructose-6-phosphate metabolic process [GO:0061611]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P34969	reviewed	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (Serotonin receptor 7)	HTR7	Homo sapiens (Human)	479	FUNCTION: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.		blood circulation [GO:0008015]; chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; smooth muscle contraction [GO:0006939]; vasoconstriction [GO:0042310]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]; trans-Golgi network membrane [GO:0032588]	G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]; trans-Golgi network membrane [GO:0032588]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; blood circulation [GO:0008015]; chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; smooth muscle contraction [GO:0006939]; vasoconstriction [GO:0042310]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P34972	reviewed	CNR2_HUMAN	Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5)	CNR2 CB2A CB2B	Homo sapiens (Human)	360	FUNCTION: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269|PubMed:10051546, ECO:0000269|PubMed:12663043, ECO:0000269|PubMed:12711605, ECO:0000269|PubMed:18692962}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; inflammatory response [GO:0006954]; leukocyte chemotaxis [GO:0030595]; negative regulation of action potential [GO:0045759]; negative regulation of mast cell activation [GO:0033004]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; regulation of metabolic process [GO:0019222]; response to amphetamine [GO:0001975]; response to lipopolysaccharide [GO:0032496]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]	cannabinoid receptor activity [GO:0004949]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; cannabinoid receptor activity [GO:0004949]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; inflammatory response [GO:0006954]; leukocyte chemotaxis [GO:0030595]; negative regulation of action potential [GO:0045759]; negative regulation of mast cell activation [GO:0033004]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; regulation of metabolic process [GO:0019222]; response to amphetamine [GO:0001975]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Perikaryon {ECO:0000250}. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}.
P34981	reviewed	TRFR_HUMAN	Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor)	TRHR	Homo sapiens (Human)	398	FUNCTION: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. {ECO:0000269|PubMed:26735259, ECO:0000269|PubMed:9141550}.		G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	plasma membrane [GO:0005886]	thyrotropin-releasing hormone receptor activity [GO:0004997]	plasma membrane [GO:0005886]; thyrotropin-releasing hormone receptor activity [GO:0004997]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26735259}; Multi-pass membrane protein {ECO:0000255}.
P34982	reviewed	OR1D2_HUMAN	Olfactory receptor 1D2 (Olfactory receptor 17-4) (OR17-4) (Olfactory receptor OR17-6) (Olfactory receptor-like protein HGMP07E)	OR1D2 OLFR1	Homo sapiens (Human)	312	FUNCTION: Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception. {ECO:0000269|PubMed:12663925, ECO:0000269|PubMed:15458659, ECO:0000269|PubMed:16820410}.		chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]; single fertilization [GO:0007338]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; olfactory receptor activity [GO:0004984]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16820410}; Multi-pass membrane protein {ECO:0000269|PubMed:16820410}. Note=In spermatazoa is localized in the midpiece and is translocated to the head region upon receptor stimulation with bourgeonal.
P34998	reviewed	CRFR1_HUMAN	Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)	CRHR1 CRFR CRFR1 CRHR	Homo sapiens (Human)	444	FUNCTION: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:18292205, ECO:0000269|PubMed:18801728, ECO:0000269|PubMed:23576434, ECO:0000269|PubMed:23863939}.	MISCELLANEOUS: [Isoform CRF-R2]: Major isoform. {ECO:0000305}.; MISCELLANEOUS: [Isoform CRF-R3]: Does not bind to CRF with high affinity. {ECO:0000305}.	activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenal gland development [GO:0030325]; behavioral response to ethanol [GO:0048149]; cell surface receptor signaling pathway [GO:0007166]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; corticotropin secretion [GO:0051458]; fear response [GO:0042596]; female pregnancy [GO:0007565]; general adaptation syndrome, behavioral process [GO:0051867]; immune response [GO:0006955]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; parturition [GO:0007567]; regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway [GO:0010578]; regulation of corticosterone secretion [GO:2000852]	endosome [GO:0005768]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	corticotrophin-releasing factor receptor activity [GO:0015056]; corticotropin-releasing hormone binding [GO:0051424]; G protein-coupled peptide receptor activity [GO:0008528]	endosome [GO:0005768]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; corticotrophin-releasing factor receptor activity [GO:0015056]; corticotropin-releasing hormone binding [GO:0051424]; G protein-coupled peptide receptor activity [GO:0008528]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenal gland development [GO:0030325]; behavioral response to ethanol [GO:0048149]; cell surface receptor signaling pathway [GO:0007166]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; corticotropin secretion [GO:0051458]; fear response [GO:0042596]; female pregnancy [GO:0007565]; general adaptation syndrome, behavioral process [GO:0051867]; immune response [GO:0006955]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; parturition [GO:0007567]; regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway [GO:0010578]; regulation of corticosterone secretion [GO:2000852]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.
P35030	reviewed	TRY3_HUMAN	Trypsin-3 (EC 3.4.21.4) (Brain trypsinogen) (Mesotrypsin) (Mesotrypsinogen) (Serine protease 3) (Serine protease 4) (Trypsin III) (Trypsin IV)	PRSS3 PRSS4 TRY3 TRY4	Homo sapiens (Human)	304	FUNCTION: Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. {ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:14507909, ECO:0000269|PubMed:18077447, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0000269|PubMed:9099703}.		antimicrobial humoral response [GO:0019730]; digestion [GO:0007586]; endothelial cell migration [GO:0043542]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; tertiary granule lumen [GO:1904724]	calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; tertiary granule lumen [GO:1904724]; calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; antimicrobial humoral response [GO:0019730]; digestion [GO:0007586]; endothelial cell migration [GO:0043542]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6698368}.
P35052	reviewed	GPC1_HUMAN	Glypican-1 [Cleaved into: Secreted glypican-1]	GPC1	Homo sapiens (Human)	558	FUNCTION: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. {ECO:0000250, ECO:0000269|PubMed:19936054, ECO:0000269|PubMed:21642435}.		cell migration [GO:0016477]; heparan sulfate proteoglycan catabolic process [GO:0030200]; myelin assembly [GO:0032288]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; regulation of protein localization to membrane [GO:1905475]; Schwann cell differentiation [GO:0014037]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]	copper ion binding [GO:0005507]; fibroblast growth factor binding [GO:0017134]; laminin binding [GO:0043236]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]; copper ion binding [GO:0005507]; fibroblast growth factor binding [GO:0017134]; laminin binding [GO:0043236]; cell migration [GO:0016477]; heparan sulfate proteoglycan catabolic process [GO:0030200]; myelin assembly [GO:0032288]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; regulation of protein localization to membrane [GO:1905475]; Schwann cell differentiation [GO:0014037]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP amyloid-beta peptides in lipid rafts in Alzheimer disease brains.; SUBCELLULAR LOCATION: [Secreted glypican-1]: Secreted, extracellular space.
P35070	reviewed	BTC_HUMAN	Probetacellulin [Cleaved into: Betacellulin (BTC)]	BTC	Homo sapiens (Human)	178	FUNCTION: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. {ECO:0000269|PubMed:8570211}.		cell population proliferation [GO:0008283]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell apoptotic process [GO:1904019]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB4-ERBB4 signaling pathway [GO:0038138]; negative regulation of epithelial cell apoptotic process [GO:1904036]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of urine volume [GO:0035810]	clathrin-coated endocytic vesicle membrane [GO:0030669]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	clathrin-coated endocytic vesicle membrane [GO:0030669]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; cell population proliferation [GO:0008283]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell apoptotic process [GO:1904019]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB4-ERBB4 signaling pathway [GO:0038138]; negative regulation of epithelial cell apoptotic process [GO:1904036]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of urine volume [GO:0035810]	SUBCELLULAR LOCATION: [Betacellulin]: Secreted, extracellular space.; SUBCELLULAR LOCATION: [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.
P35080	reviewed	PROF2_HUMAN	Profilin-2 (Profilin II)	PFN2	Homo sapiens (Human)	140	FUNCTION: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.		actin cytoskeleton organization [GO:0030036]; modification of postsynaptic actin cytoskeleton [GO:0098885]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of stress fiber assembly [GO:0051496]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein stabilization [GO:0050821]; regulation of actin filament polymerization [GO:0030833]; regulation of synaptic vesicle exocytosis [GO:2000300]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]	actin binding [GO:0003779]; actin monomer binding [GO:0003785]; ATP hydrolysis activity [GO:0016887]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; actin binding [GO:0003779]; actin monomer binding [GO:0003785]; ATP hydrolysis activity [GO:0016887]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; actin cytoskeleton organization [GO:0030036]; modification of postsynaptic actin cytoskeleton [GO:0098885]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of stress fiber assembly [GO:0051496]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein stabilization [GO:0050821]; regulation of actin filament polymerization [GO:0030833]; regulation of synaptic vesicle exocytosis [GO:2000300]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P35125	reviewed	UBP6_HUMAN	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6)	USP6 HRP1 TRE2	Homo sapiens (Human)	1406	FUNCTION: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. {ECO:0000269|PubMed:15509780, ECO:0000269|PubMed:16127172, ECO:0000269|PubMed:20418905}.	MISCELLANEOUS: The USP6 gene only exists in the primate lineage.; MISCELLANEOUS: [Isoform 3]: Was shown to be tumorigenic in transfected mice and seems not to act as GTPase activating protein. {ECO:0000305}.	protein deubiquitination [GO:0016579]; protein modification process [GO:0036211]; regulation of vesicle-mediated transport [GO:0060627]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	calmodulin binding [GO:0005516]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; calmodulin binding [GO:0005516]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; nucleic acid binding [GO:0003676]; protein deubiquitination [GO:0016579]; protein modification process [GO:0036211]; regulation of vesicle-mediated transport [GO:0060627]	SUBCELLULAR LOCATION: Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.
P35212	reviewed	CXA4_HUMAN	Gap junction alpha-4 protein (Connexin-37) (Cx37)	GJA4	Homo sapiens (Human)	333	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.		blood vessel development [GO:0001568]; calcium ion transport [GO:0006816]; cell-cell junction assembly [GO:0007043]; cell-cell signaling [GO:0007267]; endothelium development [GO:0003158]; response to pain [GO:0048265]	connexin complex [GO:0005922]; gap junction [GO:0005921]; plasma membrane [GO:0005886]	gap junction channel activity [GO:0005243]	connexin complex [GO:0005922]; gap junction [GO:0005921]; plasma membrane [GO:0005886]; gap junction channel activity [GO:0005243]; blood vessel development [GO:0001568]; calcium ion transport [GO:0006816]; cell-cell junction assembly [GO:0007043]; cell-cell signaling [GO:0007267]; endothelium development [GO:0003158]; response to pain [GO:0048265]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
P35218	reviewed	CAH5A_HUMAN	Carbonic anhydrase 5A, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VA) (Carbonic anhydrase VA) (CA-VA)	CA5A CA5	Homo sapiens (Human)	305	FUNCTION: Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3 (PubMed:8356065, PubMed:24530203). Mitochondria are impermeable to HCO3, and thus this intramitochondrial carbonic anhydrase is pivotal in providing HCO3 for multiple mitochondrial enzymes that catalyze the formation of essential metabolites of intermediary metabolism in the urea and Krebs cycles (PubMed:24530203). {ECO:0000269|PubMed:24530203, ECO:0000269|PubMed:8356065}.		one-carbon metabolic process [GO:0006730]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]; one-carbon metabolic process [GO:0006730]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:8356065}.
P35219	reviewed	CAH8_HUMAN	Carbonic anhydrase-related protein (CARP) (Carbonic anhydrase VIII) (CA-VIII)	CA8 CALS	Homo sapiens (Human)	290	FUNCTION: Does not have a carbonic anhydrase catalytic activity.		one-carbon metabolic process [GO:0006730]; phosphatidylinositol-mediated signaling [GO:0048015]	cytoplasm [GO:0005737]	carbonate dehydratase activity [GO:0004089]; hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; carbonate dehydratase activity [GO:0004089]; hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270]; one-carbon metabolic process [GO:0006730]; phosphatidylinositol-mediated signaling [GO:0048015]	
P35221	reviewed	CTNA1_HUMAN	Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)	CTNNA1	Homo sapiens (Human)	906	FUNCTION: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}.	MISCELLANEOUS: [Isoform 3]: Expressed at high levels in the nervous system. Lacks the beta-catenin interaction domain. {ECO:0000305}.	apical junction assembly [GO:0043297]; axon regeneration [GO:0031103]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cellular response to indole-3-methanol [GO:0071681]; epithelial cell-cell adhesion [GO:0090136]; establishment or maintenance of cell polarity [GO:0007163]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; gap junction assembly [GO:0016264]; integrin-mediated signaling pathway [GO:0007229]; male gonad development [GO:0008584]; negative regulation of cell motility [GO:2000146]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of protein localization to nucleus [GO:1900181]; neuroblast proliferation [GO:0007405]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization [GO:0008104]; response to estrogen [GO:0043627]; smoothened signaling pathway [GO:0007224]	acrosomal vesicle [GO:0001669]; actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; zonula adherens [GO:0005915]	actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; gamma-catenin binding [GO:0045295]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; vinculin binding [GO:0017166]	acrosomal vesicle [GO:0001669]; actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; zonula adherens [GO:0005915]; actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; gamma-catenin binding [GO:0045295]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; vinculin binding [GO:0017166]; apical junction assembly [GO:0043297]; axon regeneration [GO:0031103]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cellular response to indole-3-methanol [GO:0071681]; epithelial cell-cell adhesion [GO:0090136]; establishment or maintenance of cell polarity [GO:0007163]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; gap junction assembly [GO:0016264]; integrin-mediated signaling pathway [GO:0007229]; male gonad development [GO:0008584]; negative regulation of cell motility [GO:2000146]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of protein localization to nucleus [GO:1900181]; neuroblast proliferation [GO:0007405]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization [GO:0008104]; response to estrogen [GO:0043627]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:21708131}; Peripheral membrane protein {ECO:0000269|PubMed:21708131}; Cytoplasmic side {ECO:0000269|PubMed:21708131}.
P35222	reviewed	CTNB1_HUMAN	Catenin beta-1 (Beta-catenin)	CTNNB1 CTNNB OK/SW-cl.35 PRO2286	Homo sapiens (Human)	781	FUNCTION: Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938}.		acinar cell differentiation [GO:0090425]; adherens junction assembly [GO:0034333]; anterior/posterior axis specification [GO:0009948]; apoptotic signaling pathway [GO:0097190]; astrocyte-dopaminergic neuron signaling [GO:0036520]; bone resorption [GO:0045453]; branching involved in blood vessel morphogenesis [GO:0001569]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical NF-kappaB signal transduction [GO:0007249]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [GO:0044338]; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954]; canonical Wnt signaling pathway involved in negative regulation of apoptotic process [GO:0044336]; canonical Wnt signaling pathway involved in osteoblast differentiation [GO:0044339]; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [GO:0061324]; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [GO:0044334]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; cell maturation [GO:0048469]; cell morphogenesis involved in differentiation [GO:0000904]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular response to growth factor stimulus [GO:0071363]; cellular response to indole-3-methanol [GO:0071681]; central nervous system vasculogenesis [GO:0022009]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; cranial ganglion development [GO:0061550]; cranial skeletal system development [GO:1904888]; detection of muscle stretch [GO:0035995]; dorsal root ganglion development [GO:1990791]; dorsal/ventral axis specification [GO:0009950]; ectoderm development [GO:0007398]; embryonic axis specification [GO:0000578]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic foregut morphogenesis [GO:0048617]; embryonic forelimb morphogenesis [GO:0035115]; embryonic heart tube development [GO:0035050]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal limb joint morphogenesis [GO:0036023]; endodermal cell fate commitment [GO:0001711]; endothelial tube morphogenesis [GO:0061154]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; epithelial to mesenchymal transition [GO:0001837]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fungiform papilla formation [GO:0061198]; gastrulation with mouth forming second [GO:0001702]; genitalia morphogenesis [GO:0035112]; glial cell fate determination [GO:0007403]; hair cell differentiation [GO:0035315]; hair follicle morphogenesis [GO:0031069]; hair follicle placode formation [GO:0060789]; hindbrain development [GO:0030902]; hypothalamus development [GO:0021854]; in utero embryonic development [GO:0001701]; layer formation in cerebral cortex [GO:0021819]; lens morphogenesis in camera-type eye [GO:0002089]; lung epithelial cell differentiation [GO:0060487]; lung induction [GO:0060492]; lung-associated mesenchyme development [GO:0060484]; male genitalia development [GO:0030539]; MAPK cascade [GO:0000165]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesenchymal stem cell differentiation [GO:0072497]; metanephros morphogenesis [GO:0003338]; midbrain dopaminergic neuron differentiation [GO:1904948]; myoblast proliferation [GO:0051450]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003340]; negative regulation of mitotic cell cycle, embryonic [GO:0045976]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephron tubule formation [GO:0072079]; neural plate development [GO:0001840]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; neuron migration [GO:0001764]; neuron projection extension [GO:1990138]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; oocyte development [GO:0048599]; osteoclast differentiation [GO:0030316]; oviduct development [GO:0060066]; pancreas development [GO:0031016]; positive regulation of apoptotic process [GO:0043065]; positive regulation of branching involved in lung morphogenesis [GO:0061047]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell differentiation [GO:0045597]; positive regulation of determination of dorsal identity [GO:2000017]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of gene expression [GO:0010628]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein localization to cell surface [GO:0034394]; protein polyubiquitination [GO:0000209]; proximal/distal pattern formation [GO:0009954]; regulation of angiogenesis [GO:0045765]; regulation of calcium ion import [GO:0090279]; regulation of centriole-centriole cohesion [GO:0030997]; regulation of centromeric sister chromatid cohesion [GO:0070602]; regulation of fibroblast proliferation [GO:0048145]; regulation of myelination [GO:0031641]; regulation of nephron tubule epithelial cell differentiation [GO:0072182]; regulation of neurogenesis [GO:0050767]; regulation of protein localization to cell surface [GO:2000008]; regulation of protein ubiquitination [GO:0031396]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of synapse assembly [GO:0051963]; regulation of T cell proliferation [GO:0042129]; regulation of timing of anagen [GO:0051884]; renal inner medulla development [GO:0072053]; renal outer medulla development [GO:0072054]; renal vesicle formation [GO:0072033]; response to estradiol [GO:0032355]; response to xenobiotic stimulus [GO:0009410]; smooth muscle cell differentiation [GO:0051145]; stem cell population maintenance [GO:0019827]; stem cell proliferation [GO:0072089]; sympathetic ganglion development [GO:0061549]; synapse organization [GO:0050808]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle transport [GO:0048489]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]; trachea formation [GO:0060440]; transcription by RNA polymerase II [GO:0006366]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; beta-catenin destruction complex [GO:0030877]; beta-catenin-ICAT complex [GO:1990711]; beta-catenin-TCF complex [GO:1990907]; beta-catenin-TCF7L2 complex [GO:0070369]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; fascia adherens [GO:0005916]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; Schaffer collateral - CA1 synapse [GO:0098685]; Scrib-APC-beta-catenin complex [GO:0034750]; spindle pole [GO:0000922]; synapse [GO:0045202]; transcription regulator complex [GO:0005667]; Wnt signalosome [GO:1990909]; Z disc [GO:0030018]	alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; disordered domain specific binding [GO:0097718]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; I-SMAD binding [GO:0070411]; kinase binding [GO:0019900]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; beta-catenin destruction complex [GO:0030877]; beta-catenin-ICAT complex [GO:1990711]; beta-catenin-TCF complex [GO:1990907]; beta-catenin-TCF7L2 complex [GO:0070369]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; fascia adherens [GO:0005916]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; Schaffer collateral - CA1 synapse [GO:0098685]; Scrib-APC-beta-catenin complex [GO:0034750]; spindle pole [GO:0000922]; synapse [GO:0045202]; transcription regulator complex [GO:0005667]; Wnt signalosome [GO:1990909]; Z disc [GO:0030018]; alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; disordered domain specific binding [GO:0097718]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; I-SMAD binding [GO:0070411]; kinase binding [GO:0019900]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; acinar cell differentiation [GO:0090425]; adherens junction assembly [GO:0034333]; anterior/posterior axis specification [GO:0009948]; apoptotic signaling pathway [GO:0097190]; astrocyte-dopaminergic neuron signaling [GO:0036520]; bone resorption [GO:0045453]; branching involved in blood vessel morphogenesis [GO:0001569]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical NF-kappaB signal transduction [GO:0007249]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [GO:0044338]; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954]; canonical Wnt signaling pathway involved in negative regulation of apoptotic process [GO:0044336]; canonical Wnt signaling pathway involved in osteoblast differentiation [GO:0044339]; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [GO:0061324]; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [GO:0044334]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; cell maturation [GO:0048469]; cell morphogenesis involved in differentiation [GO:0000904]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular response to growth factor stimulus [GO:0071363]; cellular response to indole-3-methanol [GO:0071681]; central nervous system vasculogenesis [GO:0022009]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; cranial ganglion development [GO:0061550]; cranial skeletal system development [GO:1904888]; detection of muscle stretch [GO:0035995]; dorsal root ganglion development [GO:1990791]; dorsal/ventral axis specification [GO:0009950]; ectoderm development [GO:0007398]; embryonic axis specification [GO:0000578]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic foregut morphogenesis [GO:0048617]; embryonic forelimb morphogenesis [GO:0035115]; embryonic heart tube development [GO:0035050]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal limb joint morphogenesis [GO:0036023]; endodermal cell fate commitment [GO:0001711]; endothelial tube morphogenesis [GO:0061154]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; epithelial to mesenchymal transition [GO:0001837]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fungiform papilla formation [GO:0061198]; gastrulation with mouth forming second [GO:0001702]; genitalia morphogenesis [GO:0035112]; glial cell fate determination [GO:0007403]; hair cell differentiation [GO:0035315]; hair follicle morphogenesis [GO:0031069]; hair follicle placode formation [GO:0060789]; hindbrain development [GO:0030902]; hypothalamus development [GO:0021854]; in utero embryonic development [GO:0001701]; layer formation in cerebral cortex [GO:0021819]; lens morphogenesis in camera-type eye [GO:0002089]; lung epithelial cell differentiation [GO:0060487]; lung induction [GO:0060492]; lung-associated mesenchyme development [GO:0060484]; male genitalia development [GO:0030539]; MAPK cascade [GO:0000165]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesenchymal stem cell differentiation [GO:0072497]; metanephros morphogenesis [GO:0003338]; midbrain dopaminergic neuron differentiation [GO:1904948]; myoblast proliferation [GO:0051450]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003340]; negative regulation of mitotic cell cycle, embryonic [GO:0045976]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephron tubule formation [GO:0072079]; neural plate development [GO:0001840]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; neuron migration [GO:0001764]; neuron projection extension [GO:1990138]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; oocyte development [GO:0048599]; osteoclast differentiation [GO:0030316]; oviduct development [GO:0060066]; pancreas development [GO:0031016]; positive regulation of apoptotic process [GO:0043065]; positive regulation of branching involved in lung morphogenesis [GO:0061047]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell differentiation [GO:0045597]; positive regulation of determination of dorsal identity [GO:2000017]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of gene expression [GO:0010628]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein localization to cell surface [GO:0034394]; protein polyubiquitination [GO:0000209]; proximal/distal pattern formation [GO:0009954]; regulation of angiogenesis [GO:0045765]; regulation of calcium ion import [GO:0090279]; regulation of centriole-centriole cohesion [GO:0030997]; regulation of centromeric sister chromatid cohesion [GO:0070602]; regulation of fibroblast proliferation [GO:0048145]; regulation of myelination [GO:0031641]; regulation of nephron tubule epithelial cell differentiation [GO:0072182]; regulation of neurogenesis [GO:0050767]; regulation of protein localization to cell surface [GO:2000008]; regulation of protein ubiquitination [GO:0031396]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of synapse assembly [GO:0051963]; regulation of T cell proliferation [GO:0042129]; regulation of timing of anagen [GO:0051884]; renal inner medulla development [GO:0072053]; renal outer medulla development [GO:0072054]; renal vesicle formation [GO:0072033]; response to estradiol [GO:0032355]; response to xenobiotic stimulus [GO:0009410]; smooth muscle cell differentiation [GO:0051145]; stem cell population maintenance [GO:0019827]; stem cell proliferation [GO:0072089]; sympathetic ganglion development [GO:0061549]; synapse organization [GO:0050808]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle transport [GO:0048489]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]; trachea formation [GO:0060440]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25183871, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:31801859}. Nucleus {ECO:0000269|PubMed:24342833, ECO:0000269|PubMed:25183871, ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29367600, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:31801859}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:B6V8E6}. Cell junction, adherens junction {ECO:0000269|PubMed:10725230}. Cell junction {ECO:0000250|UniProtKB:B6V8E6}. Cell membrane {ECO:0000269|PubMed:11790773, ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Synapse {ECO:0000250|UniProtKB:Q02248}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q02248}. Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is un-stable (highly phosphorylated) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Interaction with FAM53B promotes translocation to the nucleus (PubMed:25183871). {ECO:0000250|UniProtKB:B6V8E6, ECO:0000269|PubMed:25183871}.
P35225	reviewed	IL13_HUMAN	Interleukin-13 (IL-13)	IL13 NC30	Homo sapiens (Human)	146	FUNCTION: Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:8096327, PubMed:8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed:7903680, PubMed:8759755). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils (PubMed:8639787). Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:9013879). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:21622864). {ECO:0000250|UniProtKB:P20109, ECO:0000250|UniProtKB:P42203, ECO:0000269|PubMed:21622864, ECO:0000269|PubMed:7903680, ECO:0000269|PubMed:8096327, ECO:0000269|PubMed:8097324, ECO:0000269|PubMed:8639787, ECO:0000269|PubMed:8759755, ECO:0000269|PubMed:9013879}.		cellular response to cytokine stimulus [GO:0071345]; cellular response to mechanical stimulus [GO:0071260]; immune response [GO:0006955]; inflammatory response [GO:0006954]; macrophage activation [GO:0042116]; microglial cell activation [GO:0001774]; negative regulation of complement-dependent cytotoxicity [GO:1903660]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lung ciliated cell differentiation [GO:1901247]; negative regulation of transforming growth factor beta production [GO:0071635]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of connective tissue growth factor production [GO:0032723]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of lung goblet cell differentiation [GO:1901251]; positive regulation of macrophage activation [GO:0043032]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of pancreatic stellate cell proliferation [GO:2000231]; positive regulation of protein secretion [GO:0050714]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of proton transport [GO:0010155]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; interleukin-13 receptor binding [GO:0005144]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; interleukin-13 receptor binding [GO:0005144]; cellular response to cytokine stimulus [GO:0071345]; cellular response to mechanical stimulus [GO:0071260]; immune response [GO:0006955]; inflammatory response [GO:0006954]; macrophage activation [GO:0042116]; microglial cell activation [GO:0001774]; negative regulation of complement-dependent cytotoxicity [GO:1903660]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lung ciliated cell differentiation [GO:1901247]; negative regulation of transforming growth factor beta production [GO:0071635]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of connective tissue growth factor production [GO:0032723]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of lung goblet cell differentiation [GO:1901251]; positive regulation of macrophage activation [GO:0043032]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of pancreatic stellate cell proliferation [GO:2000231]; positive regulation of protein secretion [GO:0050714]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of proton transport [GO:0010155]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]	SUBCELLULAR LOCATION: Secreted.
P35226	reviewed	BMI1_HUMAN	Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)	BMI1 PCGF4 RNF51	Homo sapiens (Human)	326	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249). {ECO:0000269|PubMed:15386022, ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:16882984, ECO:0000269|PubMed:21772249, ECO:0000269|PubMed:25355358, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:27827373}.	MISCELLANEOUS: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.	apoptotic signaling pathway [GO:0097190]; brain development [GO:0007420]; chromatin remodeling [GO:0006338]; DNA methylation [GO:0006306]; embryonic skeletal system morphogenesis [GO:0048704]; hemopoiesis [GO:0030097]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; regulation of adaxial/abaxial pattern formation [GO:2000011]; regulation of gene expression [GO:0010468]; rostrocaudal neural tube patterning [GO:0021903]; segment specification [GO:0007379]; somatic stem cell division [GO:0048103]	cytosol [GO:0005829]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; ubiquitin ligase complex [GO:0000151]	promoter-specific chromatin binding [GO:1990841]; RING-like zinc finger domain binding [GO:0071535]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin-protein transferase activator activity [GO:0097027]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; ubiquitin ligase complex [GO:0000151]; promoter-specific chromatin binding [GO:1990841]; RING-like zinc finger domain binding [GO:0071535]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin-protein transferase activator activity [GO:0097027]; zinc ion binding [GO:0008270]; apoptotic signaling pathway [GO:0097190]; brain development [GO:0007420]; chromatin remodeling [GO:0006338]; DNA methylation [GO:0006306]; embryonic skeletal system morphogenesis [GO:0048704]; hemopoiesis [GO:0030097]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; regulation of adaxial/abaxial pattern formation [GO:2000011]; regulation of gene expression [GO:0010468]; rostrocaudal neural tube patterning [GO:0021903]; segment specification [GO:0007379]; somatic stem cell division [GO:0048103]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16882984, ECO:0000269|PubMed:9199346}. Cytoplasm {ECO:0000269|PubMed:16882984}.
P35227	reviewed	PCGF2_HUMAN	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)	PCGF2 MEL18 RNF110 ZNF144	Homo sapiens (Human)	344	FUNCTION: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). {ECO:0000250|UniProtKB:P23798, ECO:0000269|PubMed:26151332}.		anterior/posterior pattern specification [GO:0009952]; apoptotic signaling pathway [GO:0097190]; cellular response to hydrogen peroxide [GO:0070301]; chromatin remodeling [GO:0006338]; embryonic skeletal system morphogenesis [GO:0048704]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of transcription by RNA polymerase II [GO:0000122]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; anterior/posterior pattern specification [GO:0009952]; apoptotic signaling pathway [GO:0097190]; cellular response to hydrogen peroxide [GO:0070301]; chromatin remodeling [GO:0006338]; embryonic skeletal system morphogenesis [GO:0048704]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530}.
P35228	reviewed	NOS2_HUMAN	Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)	NOS2 NOS2A	Homo sapiens (Human)	1153	FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004, PubMed:7682706, PubMed:7504305). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109). {ECO:0000250|UniProtKB:P29477, ECO:0000269|PubMed:19688109, ECO:0000269|PubMed:25417112, ECO:0000269|PubMed:7504305, ECO:0000269|PubMed:7531687, ECO:0000269|PubMed:7544004, ECO:0000269|PubMed:7682706}.		arginine catabolic process [GO:0006527]; cell redox homeostasis [GO:0045454]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cellular response to xenobiotic stimulus [GO:0071466]; circadian rhythm [GO:0007623]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; inflammatory response [GO:0006954]; innate immune response in mucosa [GO:0002227]; negative regulation of blood pressure [GO:0045776]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; peptidyl-cysteine S-nitrosylation [GO:0018119]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of killing of cells of another organism [GO:0051712]; positive regulation of leukocyte mediated cytotoxicity [GO:0001912]; prostaglandin secretion [GO:0032310]; regulation of cell population proliferation [GO:0042127]; regulation of cellular respiration [GO:0043457]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of insulin secretion [GO:0050796]; response to bacterium [GO:0009617]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; superoxide metabolic process [GO:0006801]	cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]	arginine binding [GO:0034618]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; protein homodimerization activity [GO:0042803]; tetrahydrobiopterin binding [GO:0034617]	cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; arginine binding [GO:0034618]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; protein homodimerization activity [GO:0042803]; tetrahydrobiopterin binding [GO:0034617]; arginine catabolic process [GO:0006527]; cell redox homeostasis [GO:0045454]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cellular response to xenobiotic stimulus [GO:0071466]; circadian rhythm [GO:0007623]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; inflammatory response [GO:0006954]; innate immune response in mucosa [GO:0002227]; negative regulation of blood pressure [GO:0045776]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; peptidyl-cysteine S-nitrosylation [GO:0018119]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of killing of cells of another organism [GO:0051712]; positive regulation of leukocyte mediated cytotoxicity [GO:0001912]; prostaglandin secretion [GO:0032310]; regulation of cell population proliferation [GO:0042127]; regulation of cellular respiration [GO:0043457]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of insulin secretion [GO:0050796]; response to bacterium [GO:0009617]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21199876}. Note=Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization. {ECO:0000269|PubMed:21199876}.
P35232	reviewed	PHB1_HUMAN	Prohibitin 1	PHB1 PHB	Homo sapiens (Human)	272	FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). {ECO:0000250|UniProtKB:P67778, ECO:0000250|UniProtKB:P67779, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:P67778, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305}.; FUNCTION: In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (PubMed:14500729). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (PubMed:31899195). {ECO:0000269|PubMed:14500729, ECO:0000269|PubMed:31899195}.; FUNCTION: In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (By similarity). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:P67778}.		activation of phospholipase C activity [GO:0007202]; activation of protein kinase C activity [GO:1990051]; antiviral innate immune response [GO:0140374]; B cell activation [GO:0042113]; CD40 signaling pathway [GO:0023035]; cellular response to interleukin-6 [GO:0071354]; DNA biosynthetic process [GO:0071897]; epigenetic regulation of gene expression [GO:0040029]; mitochondrion organization [GO:0007005]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of complement activation [GO:0045917]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell proliferation [GO:0048661]; progesterone receptor signaling pathway [GO:0050847]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; RIG-I signaling pathway [GO:0039529]; signal transduction [GO:0007165]; T-helper 17 type immune response [GO:0072538]; viral entry into host cell [GO:0046718]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial prohibitin complex [GO:0035632]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	complement component C3a binding [GO:0001850]; complement component C3b binding [GO:0001851]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; proteinase activated receptor binding [GO:0031871]; transcription corepressor activity [GO:0003714]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial prohibitin complex [GO:0035632]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; complement component C3a binding [GO:0001850]; complement component C3b binding [GO:0001851]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; proteinase activated receptor binding [GO:0031871]; transcription corepressor activity [GO:0003714]; activation of phospholipase C activity [GO:0007202]; activation of protein kinase C activity [GO:1990051]; antiviral innate immune response [GO:0140374]; B cell activation [GO:0042113]; CD40 signaling pathway [GO:0023035]; cellular response to interleukin-6 [GO:0071354]; DNA biosynthetic process [GO:0071897]; epigenetic regulation of gene expression [GO:0040029]; mitochondrion organization [GO:0007005]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of complement activation [GO:0045917]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell proliferation [GO:0048661]; progesterone receptor signaling pathway [GO:0050847]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; RIG-I signaling pathway [GO:0039529]; signal transduction [GO:0007165]; T-helper 17 type immune response [GO:0072538]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:14500729, ECO:0000269|PubMed:20959514}. Nucleus {ECO:0000269|PubMed:14500729, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:31899195}. Cytoplasm {ECO:0000269|PubMed:14500729, ECO:0000269|PubMed:31899195}. Cell membrane {ECO:0000269|PubMed:22997079, ECO:0000269|PubMed:24003225}.
P35236	reviewed	PTN7_HUMAN	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP)	PTPN7	Homo sapiens (Human)	360	FUNCTION: Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. {ECO:0000269|PubMed:10206983, ECO:0000269|PubMed:10559944, ECO:0000269|PubMed:10702794, ECO:0000269|PubMed:1510684, ECO:0000269|PubMed:1530918, ECO:0000269|PubMed:9624114}.		MAPK cascade [GO:0000165]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]	non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; MAPK cascade [GO:0000165]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14613483}. Cytoplasm, cytoskeleton {ECO:0000250}.
P35237	reviewed	SPB6_HUMAN	Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor)	SERPINB6 PI6 PTI	Homo sapiens (Human)	376	FUNCTION: May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. {ECO:0000250, ECO:0000269|PubMed:10068683, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8136380, ECO:0000269|PubMed:8415716}.		cellular response to osmotic stress [GO:0071470]; negative regulation of endopeptidase activity [GO:0010951]; sensory perception of sound [GO:0007605]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; serine protease inhibitor complex [GO:0097180]; tertiary granule membrane [GO:0070821]	protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; serine protease inhibitor complex [GO:0097180]; tertiary granule membrane [GO:0070821]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; cellular response to osmotic stress [GO:0071470]; negative regulation of endopeptidase activity [GO:0010951]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8486644}.
P35240	reviewed	MERL_HUMAN	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)	NF2 SCH	Homo sapiens (Human)	595	FUNCTION: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20178741, ECO:0000269|PubMed:21167305}.		actin cytoskeleton organization [GO:0030036]; cell-cell junction organization [GO:0045216]; ectoderm development [GO:0007398]; hippocampus development [GO:0021766]; lens fiber cell differentiation [GO:0070306]; MAPK cascade [GO:0000165]; mesoderm formation [GO:0001707]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast proliferation [GO:0033687]; positive regulation of cell differentiation [GO:0045597]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of stress fiber assembly [GO:0051496]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell shape [GO:0008360]; regulation of gliogenesis [GO:0014013]; regulation of hippo signaling [GO:0035330]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of organelle assembly [GO:1902115]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein stability [GO:0031647]; regulation of stem cell proliferation [GO:0072091]; Schwann cell proliferation [GO:0014010]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; cell body [GO:0044297]; cleavage furrow [GO:0032154]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	actin binding [GO:0003779]; integrin binding [GO:0005178]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; cell body [GO:0044297]; cleavage furrow [GO:0032154]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; actin binding [GO:0003779]; integrin binding [GO:0005178]; actin cytoskeleton organization [GO:0030036]; cell-cell junction organization [GO:0045216]; ectoderm development [GO:0007398]; hippocampus development [GO:0021766]; lens fiber cell differentiation [GO:0070306]; MAPK cascade [GO:0000165]; mesoderm formation [GO:0001707]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast proliferation [GO:0033687]; positive regulation of cell differentiation [GO:0045597]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of stress fiber assembly [GO:0051496]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell shape [GO:0008360]; regulation of gliogenesis [GO:0014013]; regulation of hippo signaling [GO:0035330]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of organelle assembly [GO:1902115]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein stability [GO:0031647]; regulation of stem cell proliferation [GO:0072091]; Schwann cell proliferation [GO:0014010]	SUBCELLULAR LOCATION: [Isoform 1]: Cell projection, filopodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=In a fibroblastic cell line, isoform 1 is found homogeneously distributed over the entire cell, with a particularly strong staining in ruffling membranes and filopodia. Colocalizes with MPP1 in non-myelin-forming Schwann cells. Binds with DCAF1 in the nucleus. The intramolecular association of the FERM domain with the C-terminal tail promotes nuclear accumulation. The unphosphorylated form accumulates predominantly in the nucleus while the phosphorylated form is largely confined to the non-nuclear fractions.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm, perinuclear region. Cytoplasmic granule. Note=Observed in cytoplasmic granules concentrated in a perinuclear location. Isoform 7 is absent from ruffling membranes and filopodia.; SUBCELLULAR LOCATION: [Isoform 9]: Cytoplasm, perinuclear region. Cytoplasmic granule. Note=Observed in cytoplasmic granules concentrated in a perinuclear location. Isoform 9 is absent from ruffling membranes and filopodia.; SUBCELLULAR LOCATION: [Isoform 10]: Nucleus. Cell projection, filopodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Cytoplasmic granule. Cytoplasm, cytoskeleton. Note=In a fibroblastic cell line, isoform 10 is found homogeneously distributed over the entire cell, with a particularly strong staining in ruffling membranes and filopodia.
P35241	reviewed	RADI_HUMAN	Radixin	RDX	Homo sapiens (Human)	583	FUNCTION: Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.		apical protein localization [GO:0045176]; barbed-end actin filament capping [GO:0051016]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to thyroid hormone stimulus [GO:0097067]; establishment of endothelial barrier [GO:0061028]; establishment of protein localization to plasma membrane [GO:0061951]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell size [GO:0045792]; negative regulation of GTPase activity [GO:0034260]; negative regulation of homotypic cell-cell adhesion [GO:0034111]; positive regulation of cell migration [GO:0030335]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to early endosome [GO:1902966]; protein kinase A signaling [GO:0010737]; protein localization to plasma membrane [GO:0072659]; regulation of actin filament bundle assembly [GO:0032231]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of organelle assembly [GO:1902115]; regulation of Rap protein signal transduction [GO:0032487]; regulation of ruffle assembly [GO:1900027]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell periphery [GO:0071944]; cell tip [GO:0051286]; cleavage furrow [GO:0032154]; cortical actin cytoskeleton [GO:0030864]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; midbody [GO:0030496]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]	actin binding [GO:0003779]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; protein kinase A binding [GO:0051018]; RNA binding [GO:0003723]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell periphery [GO:0071944]; cell tip [GO:0051286]; cleavage furrow [GO:0032154]; cortical actin cytoskeleton [GO:0030864]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; midbody [GO:0030496]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; actin binding [GO:0003779]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; protein kinase A binding [GO:0051018]; RNA binding [GO:0003723]; apical protein localization [GO:0045176]; barbed-end actin filament capping [GO:0051016]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to thyroid hormone stimulus [GO:0097067]; establishment of endothelial barrier [GO:0061028]; establishment of protein localization to plasma membrane [GO:0061951]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell size [GO:0045792]; negative regulation of GTPase activity [GO:0034260]; negative regulation of homotypic cell-cell adhesion [GO:0034111]; positive regulation of cell migration [GO:0030335]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to early endosome [GO:1902966]; protein kinase A signaling [GO:0010737]; protein localization to plasma membrane [GO:0072659]; regulation of actin filament bundle assembly [GO:0032231]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of organelle assembly [GO:1902115]; regulation of Rap protein signal transduction [GO:0032487]; regulation of ruffle assembly [GO:1900027]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cell projection, microvillus {ECO:0000250|UniProtKB:P26043}. Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.
P35243	reviewed	RECO_HUMAN	Recoverin (Cancer-associated retinopathy protein) (Protein CAR)	RCVRN RCV1	Homo sapiens (Human)	200	FUNCTION: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity). {ECO:0000250|UniProtKB:P21457, ECO:0000250|UniProtKB:P34057}.		phototransduction [GO:0007602]; regulation of calcium ion transport [GO:0051924]; signal transduction [GO:0007165]; visual perception [GO:0007601]	dendrite [GO:0030425]; membrane [GO:0016020]; perikaryon [GO:0043204]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]	dendrite [GO:0030425]; membrane [GO:0016020]; perikaryon [GO:0043204]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]; phototransduction [GO:0007602]; regulation of calcium ion transport [GO:0051924]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Photoreceptor inner segment {ECO:0000250|UniProtKB:P34057}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P34057}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P21457}; Lipid-anchor {ECO:0000250|UniProtKB:P21457}; Cytoplasmic side {ECO:0000250|UniProtKB:P21457}. Perikaryon {ECO:0000250|UniProtKB:P34057}. Note=Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity). Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity). {ECO:0000250|UniProtKB:P21457, ECO:0000250|UniProtKB:P34057}.
P35244	reviewed	RFA3_HUMAN	Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3)	RPA3 REPA3 RPA14	Homo sapiens (Human)	121	FUNCTION: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). {ECO:0000269|PubMed:19010961, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279, ECO:0000303|PubMed:24332808}.		base-excision repair [GO:0006284]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; mismatch repair [GO:0006298]; nucleotide-excision repair [GO:0006289]; regulation of cell population proliferation [GO:0042127]; regulation of mitotic cell cycle [GO:0007346]; telomere maintenance [GO:0000723]	DNA replication factor A complex [GO:0005662]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]	damaged DNA binding [GO:0003684]; single-stranded DNA binding [GO:0003697]	DNA replication factor A complex [GO:0005662]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; damaged DNA binding [GO:0003684]; single-stranded DNA binding [GO:0003697]; base-excision repair [GO:0006284]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; mismatch repair [GO:0006298]; nucleotide-excision repair [GO:0006289]; regulation of cell population proliferation [GO:0042127]; regulation of mitotic cell cycle [GO:0007346]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9430682}.
P35247	reviewed	SFTPD_HUMAN	Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D)	SFTPD COLEC7 PSPD SFTP4	Homo sapiens (Human)	375	FUNCTION: Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. {ECO:0000269|PubMed:23478426}.	MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).	defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; lung alveolus development [GO:0048286]; macrophage chemotaxis [GO:0048246]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of phagocytosis [GO:0050766]; reactive oxygen species metabolic process [GO:0072593]; receptor-mediated endocytosis [GO:0006898]; regulation of cytokine production [GO:0001817]; respiratory gaseous exchange by respiratory system [GO:0007585]; surfactant homeostasis [GO:0043129]	clathrin-coated endocytic vesicle [GO:0045334]; collagen trimer [GO:0005581]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; multivesicular body [GO:0005771]	carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]	clathrin-coated endocytic vesicle [GO:0045334]; collagen trimer [GO:0005581]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; lung alveolus development [GO:0048286]; macrophage chemotaxis [GO:0048246]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of phagocytosis [GO:0050766]; reactive oxygen species metabolic process [GO:0072593]; receptor-mediated endocytosis [GO:0006898]; regulation of cytokine production [GO:0001817]; respiratory gaseous exchange by respiratory system [GO:0007585]; surfactant homeostasis [GO:0043129]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
P35249	reviewed	RFC4_HUMAN	Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37)	RFC4	Homo sapiens (Human)	363	FUNCTION: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.	MISCELLANEOUS: Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP.	DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; Elg1 RFC-like complex [GO:0031391]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]	Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; Elg1 RFC-like complex [GO:0031391]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P35250	reviewed	RFC2_HUMAN	Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40)	RFC2	Homo sapiens (Human)	354	FUNCTION: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). {ECO:0000250}.		DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]	Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P35251	reviewed	RFC1_HUMAN	Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)	RFC1 RFC140	Homo sapiens (Human)	1148	FUNCTION: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859}.; FUNCTION: Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair. {ECO:0000269|PubMed:8999859}.	MISCELLANEOUS: [Isoform 2]: Alternative use of an acceptor site. {ECO:0000305}.	DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; telomere maintenance via telomerase [GO:0007004]	DNA replication factor C complex [GO:0005663]; Elg1 RFC-like complex [GO:0031391]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA clamp unloader activity [GO:0061860]; double-stranded DNA binding [GO:0003690]; enzyme activator activity [GO:0008047]; protein domain specific binding [GO:0019904]; sequence-specific DNA binding [GO:0043565]	DNA replication factor C complex [GO:0005663]; Elg1 RFC-like complex [GO:0031391]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA clamp unloader activity [GO:0061860]; double-stranded DNA binding [GO:0003690]; enzyme activator activity [GO:0008047]; protein domain specific binding [GO:0019904]; sequence-specific DNA binding [GO:0043565]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Nucleus.
P35268	reviewed	RL22_HUMAN	Large ribosomal subunit protein eL22 (60S ribosomal protein L22) (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15)	RPL22	Homo sapiens (Human)	128	FUNCTION: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.	MISCELLANEOUS: Binds to Epstein-Barr virus small RNAs and to heparin. {ECO:0000269|PubMed:1846807}.	alpha-beta T cell differentiation [GO:0046632]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]; translation at presynapse [GO:0140236]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; presynapse [GO:0098793]; ribonucleoprotein complex [GO:1990904]	heparin binding [GO:0008201]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; presynapse [GO:0098793]; ribonucleoprotein complex [GO:1990904]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; alpha-beta T cell differentiation [GO:0046632]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]; translation at presynapse [GO:0140236]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P35269	reviewed	T2FA_HUMAN	General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74)	GTF2F1 RAP74	Homo sapiens (Human)	517	FUNCTION: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}.		negative regulation of protein binding [GO:0032091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; response to virus [GO:0009615]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]	cell junction [GO:0030054]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIF complex [GO:0005674]	DNA binding [GO:0003677]; phosphatase activator activity [GO:0019211]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; TFIIF-class transcription factor complex binding [GO:0001096]	cell junction [GO:0030054]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIF complex [GO:0005674]; DNA binding [GO:0003677]; phosphatase activator activity [GO:0019211]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; TFIIF-class transcription factor complex binding [GO:0001096]; negative regulation of protein binding [GO:0032091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; response to virus [GO:0009615]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus.
P35270	reviewed	SPRE_HUMAN	Sepiapterin reductase (SPR) (EC 1.1.1.153)	SPR	Homo sapiens (Human)	261	FUNCTION: Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.		nitric oxide biosynthetic process [GO:0006809]; tetrahydrobiopterin biosynthetic process [GO:0006729]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	aldo-keto reductase (NADP) activity [GO:0004033]; NADP binding [GO:0050661]; sepiapterin reductase activity [GO:0004757]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; aldo-keto reductase (NADP) activity [GO:0004033]; NADP binding [GO:0050661]; sepiapterin reductase activity [GO:0004757]; nitric oxide biosynthetic process [GO:0006809]; tetrahydrobiopterin biosynthetic process [GO:0006729]	SUBCELLULAR LOCATION: Cytoplasm.
P35318	reviewed	ADML_HUMAN	Pro-adrenomedullin [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N-20 terminal peptide (ProAM N-terminal 20 peptide) (PAMP) (ProAM-N20)]	ADM AM	Homo sapiens (Human)	185	FUNCTION: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; amylin receptor signaling pathway [GO:0097647]; androgen metabolic process [GO:0008209]; animal organ regeneration [GO:0031100]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cAMP-mediated signaling [GO:0019933]; developmental growth [GO:0048589]; female pregnancy [GO:0007565]; G protein-coupled receptor internalization [GO:0002031]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular permeability [GO:0043116]; negative regulation of vasoconstriction [GO:0045906]; neural tube closure [GO:0001843]; neuron projection regeneration [GO:0031102]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of heart rate [GO:0010460]; positive regulation of progesterone biosynthetic process [GO:2000184]; positive regulation of vasculogenesis [GO:2001214]; receptor internalization [GO:0031623]; regulation of systemic arterial blood pressure [GO:0003073]; regulation of the force of heart contraction [GO:0002026]; regulation of urine volume [GO:0035809]; response to glucocorticoid [GO:0051384]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594]; signal transduction [GO:0007165]; spongiotrophoblast layer development [GO:0060712]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	adrenomedullin receptor binding [GO:0031700]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; adrenomedullin receptor binding [GO:0031700]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; amylin receptor signaling pathway [GO:0097647]; androgen metabolic process [GO:0008209]; animal organ regeneration [GO:0031100]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cAMP-mediated signaling [GO:0019933]; developmental growth [GO:0048589]; female pregnancy [GO:0007565]; G protein-coupled receptor internalization [GO:0002031]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular permeability [GO:0043116]; negative regulation of vasoconstriction [GO:0045906]; neural tube closure [GO:0001843]; neuron projection regeneration [GO:0031102]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of heart rate [GO:0010460]; positive regulation of progesterone biosynthetic process [GO:2000184]; positive regulation of vasculogenesis [GO:2001214]; receptor internalization [GO:0031623]; regulation of systemic arterial blood pressure [GO:0003073]; regulation of the force of heart contraction [GO:0002026]; regulation of urine volume [GO:0035809]; response to glucocorticoid [GO:0051384]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594]; signal transduction [GO:0007165]; spongiotrophoblast layer development [GO:0060712]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Secreted.
P35321	reviewed	SPR1A_HUMAN	Cornifin-A (19 kDa pancornulin) (SPRK) (Small proline-rich protein IA) (SPR-IA)	SPRR1A	Homo sapiens (Human)	89	FUNCTION: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.		epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]	cornified envelope [GO:0001533]; cytosol [GO:0005829]	structural constituent of skin epidermis [GO:0030280]; structural molecule activity [GO:0005198]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; structural constituent of skin epidermis [GO:0030280]; structural molecule activity [GO:0005198]; epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]	SUBCELLULAR LOCATION: Cytoplasm.
P35326	reviewed	SPR2A_HUMAN	Small proline-rich protein 2A (SPR-2A) (2-1)	SPRR2A	Homo sapiens (Human)	72	FUNCTION: Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (PubMed:34735226). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (By similarity). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (PubMed:8325635). {ECO:0000250|UniProtKB:P0DV37, ECO:0000269|PubMed:34735226, ECO:0000269|PubMed:8325635}.		antibacterial humoral response [GO:0019731]; defense response to Gram-positive bacterium [GO:0050830]; host-mediated regulation of intestinal microbiota composition [GO:0048874]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; transport vesicle [GO:0030133]	lipid binding [GO:0008289]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; transport vesicle [GO:0030133]; lipid binding [GO:0008289]; antibacterial humoral response [GO:0019731]; defense response to Gram-positive bacterium [GO:0050830]; host-mediated regulation of intestinal microbiota composition [GO:0048874]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34735226}. Secreted, extracellular space {ECO:0000269|PubMed:34735226}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:34735226}. Note=Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen. {ECO:0000269|PubMed:34735226}.
P35346	reviewed	SSR5_HUMAN	Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) (SST5)	SSTR5	Homo sapiens (Human)	364	FUNCTION: Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. {ECO:0000269|PubMed:12072395, ECO:0000269|PubMed:7908405, ECO:0000269|PubMed:8078491, ECO:0000269|PubMed:8373420}.		cellular response to glucocorticoid stimulus [GO:0071385]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose homeostasis [GO:0042593]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytokinesis [GO:0032467]; regulation of insulin secretion [GO:0050796]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]	neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994]; cellular response to glucocorticoid stimulus [GO:0071385]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose homeostasis [GO:0042593]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytokinesis [GO:0032467]; regulation of insulin secretion [GO:0050796]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P35348	reviewed	ADA1A_HUMAN	Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c)	ADRA1A ADRA1C	Homo sapiens (Human)	466	FUNCTION: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.	MISCELLANEOUS: [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adult heart development [GO:0007512]; apoptotic process [GO:0006915]; calcium ion transport into cytosol [GO:0060402]; cell growth involved in cardiac muscle cell development [GO:0061049]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure [GO:0001985]; neuron-glial cell signaling [GO:0150099]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; pilomotor reflex [GO:0097195]; positive regulation of action potential [GO:0045760]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of the force of heart contraction by epinephrine-norepinephrine [GO:0001997]; positive regulation of vasoconstriction [GO:0045907]; response to hormone [GO:0009725]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	alpha1-adrenergic receptor activity [GO:0004937]; protein heterodimerization activity [GO:0046982]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; alpha1-adrenergic receptor activity [GO:0004937]; protein heterodimerization activity [GO:0046982]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adult heart development [GO:0007512]; apoptotic process [GO:0006915]; calcium ion transport into cytosol [GO:0060402]; cell growth involved in cardiac muscle cell development [GO:0061049]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure [GO:0001985]; neuron-glial cell signaling [GO:0150099]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; pilomotor reflex [GO:0097195]; positive regulation of action potential [GO:0045760]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of the force of heart contraction by epinephrine-norepinephrine [GO:0001997]; positive regulation of vasoconstriction [GO:0045907]; response to hormone [GO:0009725]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]	SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Cell membrane {ECO:0000269|PubMed:24567387}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:24567387}. Membrane, caveola {ECO:0000269|PubMed:24567387}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
P35354	reviewed	PGH2_HUMAN	Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)	PTGS2 COX2	Homo sapiens (Human)	604	FUNCTION: Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response (PubMed:7947975, PubMed:7592599, PubMed:9261177, PubMed:16373578, PubMed:22942274, PubMed:26859324, PubMed:27226593, PubMed:11939906, PubMed:19540099). The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes (PubMed:7947975, PubMed:7592599, PubMed:9261177, PubMed:16373578, PubMed:22942274, PubMed:26859324, PubMed:27226593). This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975, PubMed:7592599, PubMed:9261177, PubMed:16373578, PubMed:22942274, PubMed:26859324, PubMed:27226593). Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins (PubMed:11939906, PubMed:19540099). In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids (PubMed:27642067). Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response (PubMed:22942274). Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols (PubMed:11034610, PubMed:11192938, PubMed:9048568, PubMed:9261177). Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation (PubMed:12391014). Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs) (PubMed:12391014). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further metabolized by ALOX5 and LTA4H to generate 18S-RvE1 and 18S-RvE2 (PubMed:21206090). In vascular endothelial cells, converts docosapentaenoate (DPA, C22:5(n-3)) to 13R-HDPA, a precursor for 13-series resolvins (RvTs) shown to activate macrophage phagocytosis during bacterial infection (PubMed:26236990). In activated leukocytes, contributes to oxygenation of hydroxyeicosatetraenoates (HETE) to diHETES (5,15-diHETE and 5,11-diHETE) (PubMed:22068350, PubMed:26282205). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (By similarity). During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs) 15R-lipoxin A4 that regulates phagocytic microglia (By similarity). {ECO:0000250|UniProtKB:P79208, ECO:0000250|UniProtKB:Q05769, ECO:0000269|PubMed:11034610, ECO:0000269|PubMed:11192938, ECO:0000269|PubMed:11939906, ECO:0000269|PubMed:12391014, ECO:0000269|PubMed:16373578, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:22068350, ECO:0000269|PubMed:22942274, ECO:0000269|PubMed:26236990, ECO:0000269|PubMed:26282205, ECO:0000269|PubMed:26859324, ECO:0000269|PubMed:27226593, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7592599, ECO:0000269|PubMed:7947975, ECO:0000269|PubMed:9048568, ECO:0000269|PubMed:9261177, ECO:0000303|PubMed:19540099}.	MISCELLANEOUS: The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.; MISCELLANEOUS: Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.; MISCELLANEOUS: PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen (PubMed:27710942, PubMed:26859324, PubMed:27226593). Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation (PubMed:26859324). Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration. {ECO:0000269|PubMed:26859324, ECO:0000269|PubMed:27226593, ECO:0000269|PubMed:27710942}.	angiogenesis [GO:0001525]; bone mineralization [GO:0030282]; brown fat cell differentiation [GO:0050873]; cellular response to ATP [GO:0071318]; cellular response to fluid shear stress [GO:0071498]; cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; cellular response to lead ion [GO:0071284]; cellular response to mechanical stimulus [GO:0071260]; cellular response to non-ionic osmotic stress [GO:0071471]; cyclooxygenase pathway [GO:0019371]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; hair cycle [GO:0042633]; learning [GO:0007612]; maintenance of blood-brain barrier [GO:0035633]; memory [GO:0007613]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of smooth muscle contraction [GO:0045986]; negative regulation of synaptic transmission, dopaminergic [GO:0032227]; positive regulation of apoptotic process [GO:0043065]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of fever generation [GO:0031622]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of platelet-derived growth factor production [GO:0090362]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vasoconstriction [GO:0045907]; prostaglandin biosynthetic process [GO:0001516]; prostaglandin secretion [GO:0032310]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; regulation of neuroinflammatory response [GO:0150077]; response to angiotensin [GO:1990776]; response to estradiol [GO:0032355]; response to fatty acid [GO:0070542]; response to fructose [GO:0009750]; response to glucocorticoid [GO:0051384]; response to lipopolysaccharide [GO:0032496]; response to manganese ion [GO:0010042]; response to nematode [GO:0009624]; response to oxidative stress [GO:0006979]; response to tumor necrosis factor [GO:0034612]; response to vitamin D [GO:0033280]; response to xenobiotic stimulus [GO:0009410]	caveola [GO:0005901]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; neuron projection [GO:0043005]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; protein-containing complex [GO:0032991]	enzyme binding [GO:0019899]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; peroxidase activity [GO:0004601]; prostaglandin-endoperoxide synthase activity [GO:0004666]; protein homodimerization activity [GO:0042803]	caveola [GO:0005901]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; neuron projection [GO:0043005]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; protein-containing complex [GO:0032991]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; peroxidase activity [GO:0004601]; prostaglandin-endoperoxide synthase activity [GO:0004666]; protein homodimerization activity [GO:0042803]; angiogenesis [GO:0001525]; bone mineralization [GO:0030282]; brown fat cell differentiation [GO:0050873]; cellular response to ATP [GO:0071318]; cellular response to fluid shear stress [GO:0071498]; cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; cellular response to lead ion [GO:0071284]; cellular response to mechanical stimulus [GO:0071260]; cellular response to non-ionic osmotic stress [GO:0071471]; cyclooxygenase pathway [GO:0019371]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; hair cycle [GO:0042633]; learning [GO:0007612]; maintenance of blood-brain barrier [GO:0035633]; memory [GO:0007613]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of smooth muscle contraction [GO:0045986]; negative regulation of synaptic transmission, dopaminergic [GO:0032227]; positive regulation of apoptotic process [GO:0043065]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of fever generation [GO:0031622]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of platelet-derived growth factor production [GO:0090362]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vasoconstriction [GO:0045907]; prostaglandin biosynthetic process [GO:0001516]; prostaglandin secretion [GO:0032310]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; regulation of neuroinflammatory response [GO:0150077]; response to angiotensin [GO:1990776]; response to estradiol [GO:0032355]; response to fatty acid [GO:0070542]; response to fructose [GO:0009750]; response to glucocorticoid [GO:0051384]; response to lipopolysaccharide [GO:0032496]; response to manganese ion [GO:0010042]; response to nematode [GO:0009624]; response to oxidative stress [GO:0006979]; response to tumor necrosis factor [GO:0034612]; response to vitamin D [GO:0033280]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:9545330}; Peripheral membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:9545330}; Peripheral membrane protein. Nucleus inner membrane {ECO:0000269|PubMed:9545330}; Peripheral membrane protein. Nucleus outer membrane {ECO:0000269|PubMed:9545330}; Peripheral membrane protein. Note=Detected on the lumenal side of the endoplasmic reticulum and nuclear envelope. {ECO:0000269|PubMed:9545330}.
P35367	reviewed	HRH1_HUMAN	Histamine H1 receptor (H1R) (HH1R)	HRH1	Homo sapiens (Human)	487	FUNCTION: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.		cellular response to histamine [GO:0071420]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inflammatory response [GO:0006954]; inositol phosphate-mediated signaling [GO:0048016]; memory [GO:0007613]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of vasoconstriction [GO:0045907]; regulation of synaptic plasticity [GO:0048167]; regulation of vascular permeability [GO:0043114]; visual learning [GO:0008542]	cytosol [GO:0005829]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled receptor activity [GO:0004930]; G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594]	cytosol [GO:0005829]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594]; cellular response to histamine [GO:0071420]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inflammatory response [GO:0006954]; inositol phosphate-mediated signaling [GO:0048016]; memory [GO:0007613]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of vasoconstriction [GO:0045907]; regulation of synaptic plasticity [GO:0048167]; regulation of vascular permeability [GO:0043114]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21697825}; Multi-pass membrane protein {ECO:0000269|PubMed:21697825}.
P35368	reviewed	ADA1B_HUMAN	Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor)	ADRA1B	Homo sapiens (Human)	520	FUNCTION: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.		adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; neuron-glial cell signaling [GO:0150099]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of MAPK cascade [GO:0043410]; regulation of cardiac muscle contraction [GO:0055117]; regulation of vasoconstriction [GO:0019229]	caveola [GO:0005901]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	alpha1-adrenergic receptor activity [GO:0004937]; protein heterodimerization activity [GO:0046982]	caveola [GO:0005901]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; alpha1-adrenergic receptor activity [GO:0004937]; protein heterodimerization activity [GO:0046982]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; neuron-glial cell signaling [GO:0150099]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of MAPK cascade [GO:0043410]; regulation of cardiac muscle contraction [GO:0055117]; regulation of vasoconstriction [GO:0019229]	SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Cell membrane {ECO:0000269|PubMed:24567387}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:24567387}. Membrane, caveola {ECO:0000269|PubMed:24567387}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
P35372	reviewed	OPRM_HUMAN	Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP)	OPRM1 MOR1	Homo sapiens (Human)	400	FUNCTION: Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:10529478, PubMed:7957926, PubMed:9689128). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:10529478, PubMed:9689128, PubMed:10836142, PubMed:19300905). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (By similarity). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (By similarity). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling (By similarity). Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity). {ECO:0000250|UniProtKB:P33535, ECO:0000269|PubMed:10529478, ECO:0000269|PubMed:12068084, ECO:0000269|PubMed:12589820, ECO:0000269|PubMed:7891175, ECO:0000269|PubMed:7905839, ECO:0000269|PubMed:7957926, ECO:0000269|PubMed:9689128, ECO:0000303|PubMed:10836142, ECO:0000303|PubMed:19300905}.; FUNCTION: [Isoform 12]: Couples to GNAS and is proposed to be involved in excitatory effects. {ECO:0000269|PubMed:20525224}.; FUNCTION: [Isoform 16]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}.; FUNCTION: [Isoform 17]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}.	MISCELLANEOUS: OPRM1 is the main physiological target for most clinically important opioid analgesics. OPRM1-mediated inhibition of voltage-gated calcium channels on central presynaptic terminals of primary afferent nociceptors is thought to be one of the primary mechanisms mediating analgesia at the spinal level. Opioid-induced hyperalgesic responses are observed following both acute and chronic dosing associated with cellular excitation.; MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; behavioral response to ethanol [GO:0048149]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of Wnt protein secretion [GO:0061358]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of neurogenesis [GO:0050769]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of cellular response to stress [GO:0080135]; regulation of NMDA receptor activity [GO:2000310]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]	axon [GO:0030424]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202]	beta-endorphin receptor activity [GO:0004979]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; morphine receptor activity [GO:0038047]; neuropeptide binding [GO:0042923]; voltage-gated calcium channel activity [GO:0005245]	axon [GO:0030424]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202]; beta-endorphin receptor activity [GO:0004979]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; morphine receptor activity [GO:0038047]; neuropeptide binding [GO:0042923]; voltage-gated calcium channel activity [GO:0005245]; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; behavioral response to ethanol [GO:0048149]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of Wnt protein secretion [GO:0061358]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of neurogenesis [GO:0050769]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of cellular response to stress [GO:0080135]; regulation of NMDA receptor activity [GO:2000310]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10529478, ECO:0000269|PubMed:12589820, ECO:0000269|PubMed:16580639, ECO:0000269|PubMed:7891175, ECO:0000269|PubMed:7905839, ECO:0000269|PubMed:7957926, ECO:0000269|PubMed:9689128}; Multi-pass membrane protein {ECO:0000269|PubMed:16580639}. Cell projection, axon {ECO:0000250|UniProtKB:P97266}. Perikaryon {ECO:0000250|UniProtKB:P97266}. Cell projection, dendrite {ECO:0000250|UniProtKB:P97266}. Endosome {ECO:0000250|UniProtKB:P97266}. Note=Is rapidly internalized after agonist binding. {ECO:0000250|UniProtKB:P97266}.; SUBCELLULAR LOCATION: [Isoform 12]: Cytoplasm {ECO:0000269|PubMed:20525224}.
P35398	reviewed	RORA_HUMAN	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha)	RORA NR1F1 RZRA	Homo sapiens (Human)	523	FUNCTION: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development (PubMed:29656859). Regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC1 and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling. {ECO:0000269|PubMed:10478845, ECO:0000269|PubMed:11053433, ECO:0000269|PubMed:11252722, ECO:0000269|PubMed:11554739, ECO:0000269|PubMed:12467577, ECO:0000269|PubMed:14570920, ECO:0000269|PubMed:15781255, ECO:0000269|PubMed:15790933, ECO:0000269|PubMed:16462772, ECO:0000269|PubMed:17512500, ECO:0000269|PubMed:18005000, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19965867, ECO:0000269|PubMed:21499262, ECO:0000269|PubMed:29656859, ECO:0000269|PubMed:7926749, ECO:0000269|PubMed:9328355, ECO:0000269|PubMed:9862959}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. Region from 23 to 71 inhibits DNA-binding and transactivation activity. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative promoter usage. {ECO:0000305}.	angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to sterol [GO:0036315]; cellular response to tumor necrosis factor [GO:0071356]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellar Purkinje cell differentiation [GO:0021702]; cGMP metabolic process [GO:0046068]; cholesterol homeostasis [GO:0042632]; circadian regulation of gene expression [GO:0032922]; intracellular receptor signaling pathway [GO:0030522]; muscle cell differentiation [GO:0042692]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of inflammatory response [GO:0050728]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucose metabolic process [GO:0010906]; regulation of macrophage activation [GO:0043030]; regulation of smoothened signaling pathway [GO:0008589]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 17 cell differentiation [GO:0072539]; triglyceride homeostasis [GO:0070328]; xenobiotic metabolic process [GO:0006805]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; ligand-activated transcription factor activity [GO:0098531]; nuclear receptor activity [GO:0004879]; oxysterol binding [GO:0008142]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; ligand-activated transcription factor activity [GO:0098531]; nuclear receptor activity [GO:0004879]; oxysterol binding [GO:0008142]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]; angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to sterol [GO:0036315]; cellular response to tumor necrosis factor [GO:0071356]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellar Purkinje cell differentiation [GO:0021702]; cGMP metabolic process [GO:0046068]; cholesterol homeostasis [GO:0042632]; circadian regulation of gene expression [GO:0032922]; intracellular receptor signaling pathway [GO:0030522]; muscle cell differentiation [GO:0042692]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of inflammatory response [GO:0050728]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucose metabolic process [GO:0010906]; regulation of macrophage activation [GO:0043030]; regulation of smoothened signaling pathway [GO:0008589]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 17 cell differentiation [GO:0072539]; triglyceride homeostasis [GO:0070328]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:18005000, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18658046}.
P35408	reviewed	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	PTGER4 PTGER2	Homo sapiens (Human)	488	FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nematode [GO:0009624]; T-helper cell differentiation [GO:0042093]	membrane [GO:0016020]; plasma membrane [GO:0005886]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]; prostaglandin E receptor activity [GO:0004957]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nematode [GO:0009624]; T-helper cell differentiation [GO:0042093]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P35414	reviewed	APJ_HUMAN	Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11)	APLNR AGTRL1 APJ	Homo sapiens (Human)	380	FUNCTION: Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). {ECO:0000250|UniProtKB:P79960, ECO:0000250|UniProtKB:Q7SZP9, ECO:0000250|UniProtKB:Q9WV08, ECO:0000269|PubMed:11090199, ECO:0000269|PubMed:25639753, ECO:0000269|PubMed:28137936}.; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:11090199). {ECO:0000269|PubMed:11090199}.		adult heart development [GO:0007512]; angiogenesis [GO:0001525]; aorta development [GO:0035904]; apelin receptor signaling pathway [GO:0060183]; atrioventricular valve development [GO:0003171]; blood vessel development [GO:0001568]; coronary vasculature development [GO:0060976]; endocardial cushion formation [GO:0003272]; G protein-coupled receptor signaling pathway [GO:0007186]; gastrulation [GO:0007369]; heart development [GO:0007507]; heart looping [GO:0001947]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of gene expression [GO:0010629]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of inhibitory G protein-coupled receptor phosphorylation [GO:1904325]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of body fluid levels [GO:0050878]; regulation of gap junction assembly [GO:1903596]; regulation of gene expression [GO:0010468]; vascular associated smooth muscle cell differentiation [GO:0035886]; vasculature development [GO:0001944]; vasculogenesis [GO:0001570]; venous blood vessel development [GO:0060841]; ventricular septum morphogenesis [GO:0060412]	plasma membrane [GO:0005886]	apelin receptor activity [GO:0060182]; G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; apelin receptor activity [GO:0060182]; G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023]; adult heart development [GO:0007512]; angiogenesis [GO:0001525]; aorta development [GO:0035904]; apelin receptor signaling pathway [GO:0060183]; atrioventricular valve development [GO:0003171]; blood vessel development [GO:0001568]; coronary vasculature development [GO:0060976]; endocardial cushion formation [GO:0003272]; G protein-coupled receptor signaling pathway [GO:0007186]; gastrulation [GO:0007369]; heart development [GO:0007507]; heart looping [GO:0001947]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of gene expression [GO:0010629]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of inhibitory G protein-coupled receptor phosphorylation [GO:1904325]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of body fluid levels [GO:0050878]; regulation of gap junction assembly [GO:1903596]; regulation of gene expression [GO:0010468]; vascular associated smooth muscle cell differentiation [GO:0035886]; vasculature development [GO:0001944]; vasculogenesis [GO:0001570]; venous blood vessel development [GO:0060841]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25639753}. Note=After exposure to apelin (APLN), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (By similarity). After exposure to apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:25639753). {ECO:0000250|UniProtKB:Q9JHG3, ECO:0000269|PubMed:25639753}.
P35442	reviewed	TSP2_HUMAN	Thrombospondin-2	THBS2 TSP2	Homo sapiens (Human)	1172	FUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. {ECO:0000269|PubMed:20714802}.		cell adhesion [GO:0007155]; negative regulation of angiogenesis [GO:0016525]; positive regulation of synapse assembly [GO:0051965]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; platelet alpha granule [GO:0031091]	calcium ion binding [GO:0005509]; heparin binding [GO:0008201]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; platelet alpha granule [GO:0031091]; calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; cell adhesion [GO:0007155]; negative regulation of angiogenesis [GO:0016525]; positive regulation of synapse assembly [GO:0051965]	
P35443	reviewed	TSP4_HUMAN	Thrombospondin-4	THBS4 TSP4	Homo sapiens (Human)	961	FUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity). {ECO:0000250, ECO:0000269|PubMed:19441079}.		behavioral response to pain [GO:0048266]; endothelial cell-cell adhesion [GO:0071603]; myoblast migration [GO:0051451]; negative regulation of angiogenesis [GO:0016525]; positive regulation of cell division [GO:0051781]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of tissue remodeling [GO:0034103]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]; tissue remodeling [GO:0048771]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; sarcoplasmic reticulum [GO:0016529]	calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; sarcoplasmic reticulum [GO:0016529]; calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; behavioral response to pain [GO:0048266]; endothelial cell-cell adhesion [GO:0071603]; myoblast migration [GO:0051451]; negative regulation of angiogenesis [GO:0016525]; positive regulation of cell division [GO:0051781]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of tissue remodeling [GO:0034103]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]; tissue remodeling [GO:0048771]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Z1T2}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q9Z1T2}. Secreted {ECO:0000250|UniProtKB:Q9Z1T2}. Secreted, extracellular space {ECO:0000250|UniProtKB:Q9Z1T2}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9Z1T2}.
P35452	reviewed	HXD12_HUMAN	Homeobox protein Hox-D12 (Homeobox protein Hox-4H)	HOXD12 HOX4H	Homo sapiens (Human)	270	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		embryonic digit morphogenesis [GO:0042733]; pattern specification process [GO:0007389]; skeletal system development [GO:0001501]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; embryonic digit morphogenesis [GO:0042733]; pattern specification process [GO:0007389]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Nucleus.
P35453	reviewed	HXD13_HUMAN	Homeobox protein Hox-D13 (Homeobox protein Hox-4I)	HOXD13 HOX4I	Homo sapiens (Human)	343	FUNCTION: Sequence-specific transcription factor that binds gene promoters and activates their transcription (PubMed:24789103). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity). {ECO:0000250|UniProtKB:P24344, ECO:0000269|PubMed:24789103}.		anterior/posterior pattern specification [GO:0009952]; branch elongation of an epithelium [GO:0060602]; embryonic digit morphogenesis [GO:0042733]; embryonic hindgut morphogenesis [GO:0048619]; male genitalia development [GO:0030539]; morphogenesis of an epithelial fold [GO:0060571]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; skeletal system development [GO:0001501]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; branch elongation of an epithelium [GO:0060602]; embryonic digit morphogenesis [GO:0042733]; embryonic hindgut morphogenesis [GO:0048619]; male genitalia development [GO:0030539]; morphogenesis of an epithelial fold [GO:0060571]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; skeletal system development [GO:0001501]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:24789103}.
P35462	reviewed	DRD3_HUMAN	D(3) dopamine receptor (Dopamine D3 receptor)	DRD3	Homo sapiens (Human)	400	FUNCTION: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. {ECO:0000269|PubMed:19520868}.		acid secretion [GO:0046717]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; arachidonic acid secretion [GO:0050482]; behavioral response to cocaine [GO:0048148]; circadian regulation of gene expression [GO:0032922]; dopamine metabolic process [GO:0042417]; G protein-coupled receptor internalization [GO:0002031]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; musculoskeletal movement, spinal reflex action [GO:0050883]; negative regulation of blood pressure [GO:0045776]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein secretion [GO:0050709]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytokinesis [GO:0032467]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of mitotic nuclear division [GO:0045840]; prepulse inhibition [GO:0060134]; regulation of dopamine secretion [GO:0014059]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of potassium ion transport [GO:0043266]; response to cocaine [GO:0042220]; response to histamine [GO:0034776]; response to morphine [GO:0043278]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; visual learning [GO:0008542]	plasma membrane [GO:0005886]; synapse [GO:0045202]	dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; synapse [GO:0045202]; dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; G protein-coupled receptor activity [GO:0004930]; acid secretion [GO:0046717]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; arachidonic acid secretion [GO:0050482]; behavioral response to cocaine [GO:0048148]; circadian regulation of gene expression [GO:0032922]; dopamine metabolic process [GO:0042417]; G protein-coupled receptor internalization [GO:0002031]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; musculoskeletal movement, spinal reflex action [GO:0050883]; negative regulation of blood pressure [GO:0045776]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein secretion [GO:0050709]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytokinesis [GO:0032467]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of mitotic nuclear division [GO:0045840]; prepulse inhibition [GO:0060134]; regulation of dopamine secretion [GO:0014059]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of potassium ion transport [GO:0043266]; response to cocaine [GO:0042220]; response to histamine [GO:0034776]; response to morphine [GO:0043278]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19520868}; Multi-pass membrane protein {ECO:0000269|PubMed:19520868}. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.
P35475	reviewed	IDUA_HUMAN	Alpha-L-iduronidase (EC 3.2.1.76)	IDUA	Homo sapiens (Human)	653			dermatan sulfate catabolic process [GO:0030209]; disaccharide metabolic process [GO:0005984]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparin catabolic process [GO:0030211]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]	L-iduronidase activity [GO:0003940]; signaling receptor binding [GO:0005102]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; L-iduronidase activity [GO:0003940]; signaling receptor binding [GO:0005102]; dermatan sulfate catabolic process [GO:0030209]; disaccharide metabolic process [GO:0005984]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparin catabolic process [GO:0030211]	SUBCELLULAR LOCATION: Lysosome {ECO:0000305}.
P35498	reviewed	SCN1A_HUMAN	Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)	SCN1A NAC1 SCN1	Homo sapiens (Human)	2009	FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:14672992). Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli. {ECO:0000250|UniProtKB:A2APX8, ECO:0000269|PubMed:14672992}.		adult walking behavior [GO:0007628]; calcium ion import across plasma membrane [GO:0098703]; cardiac muscle cell action potential involved in contraction [GO:0086002]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; determination of adult lifespan [GO:0008340]; establishment of localization in cell [GO:0051649]; membrane depolarization during action potential [GO:0086010]; nerve development [GO:0021675]; neuromuscular process controlling posture [GO:0050884]; neuronal action potential [GO:0019228]; neuronal action potential propagation [GO:0019227]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transport [GO:0006814]	axon initial segment [GO:0043194]; intercalated disc [GO:0014704]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018]	high voltage-gated calcium channel activity [GO:0008331]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated sodium channel activity [GO:0005248]	axon initial segment [GO:0043194]; intercalated disc [GO:0014704]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated sodium channel activity [GO:0005248]; adult walking behavior [GO:0007628]; calcium ion import across plasma membrane [GO:0098703]; cardiac muscle cell action potential involved in contraction [GO:0086002]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; determination of adult lifespan [GO:0008340]; establishment of localization in cell [GO:0051649]; membrane depolarization during action potential [GO:0086010]; nerve development [GO:0021675]; neuromuscular process controlling posture [GO:0050884]; neuronal action potential [GO:0019228]; neuronal action potential propagation [GO:0019227]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14672992, ECO:0000269|PubMed:17928445}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}.
P35499	reviewed	SCN4A_HUMAN	Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4)	SCN4A	Homo sapiens (Human)	1836	FUNCTION: Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states (PubMed:12766226, PubMed:29992740, PubMed:30190309, PubMed:15318338, PubMed:16890191, PubMed:18690054, PubMed:17898326, PubMed:19347921, PubMed:25707578, PubMed:26700687). Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels (PubMed:12766226, PubMed:15318338, PubMed:16890191, PubMed:19347921, PubMed:25707578, PubMed:26700687, PubMed:26659129). {ECO:0000269|PubMed:12766226, ECO:0000269|PubMed:15318338, ECO:0000269|PubMed:16890191, ECO:0000269|PubMed:17898326, ECO:0000269|PubMed:18690054, ECO:0000269|PubMed:19347921, ECO:0000269|PubMed:25707578, ECO:0000269|PubMed:26659129, ECO:0000269|PubMed:26700687, ECO:0000269|PubMed:29992740, ECO:0000269|PubMed:30190309}.		calcium ion import across plasma membrane [GO:0098703]; muscle contraction [GO:0006936]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of skeletal muscle contraction by action potential [GO:0100001]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]	high voltage-gated calcium channel activity [GO:0008331]; voltage-gated sodium channel activity [GO:0005248]	plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated sodium channel activity [GO:0005248]; calcium ion import across plasma membrane [GO:0098703]; muscle contraction [GO:0006936]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of skeletal muscle contraction by action potential [GO:0100001]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12766226, ECO:0000269|PubMed:15318338, ECO:0000269|PubMed:16890191, ECO:0000269|PubMed:17898326, ECO:0000269|PubMed:18690054, ECO:0000269|PubMed:19347921, ECO:0000269|PubMed:25707578, ECO:0000269|PubMed:26659129, ECO:0000269|PubMed:26700687, ECO:0000269|PubMed:29992740, ECO:0000269|PubMed:30190309}; Multi-pass membrane protein {ECO:0000269|PubMed:30190309}.
P35503	reviewed	UD13_HUMAN	UDP-glucuronosyltransferase 1A3 (UGT1A3) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-3) (UDPGT 1-3) (UGT1*3) (UGT1-03) (UGT1.3) (UDP-glucuronosyltransferase 1-C) (UGT-1C) (UGT1C) (UDP-glucuronosyltransferase 1A isoform 3)	UGT1A3 GNT1 UGT1	Homo sapiens (Human)	534	FUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23756265, PubMed:23288867, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229, PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515). {ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:23756265, ECO:0000269|PubMed:24641623}.; FUNCTION: [Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558}.	MISCELLANEOUS: UGT1A3 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity. {ECO:0000269|PubMed:18004212}.	bile acid secretion [GO:0032782]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; flavonoid glucuronidation [GO:0052696]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; retinoic acid metabolic process [GO:0042573]; vitamin D3 metabolic process [GO:0070640]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]; bile acid secretion [GO:0032782]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; flavonoid glucuronidation [GO:0052696]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; retinoic acid metabolic process [GO:0042573]; vitamin D3 metabolic process [GO:0070640]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17179145}; Single-pass membrane protein {ECO:0000255}.
P35504	reviewed	UD15_HUMAN	UDP-glucuronosyltransferase 1A5 (UGT1A5) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-5) (UDPGT 1-5) (UGT1*5) (UGT1-05) (UGT1.5) (UDP-glucuronosyltransferase 1-E) (UGT-1E) (UGT1E)	UGT1A5 GNT1 UGT1	Homo sapiens (Human)	534	FUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18674515). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18674515). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist zolarsatan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). {ECO:0000269|PubMed:18674515}.; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004212}.	MISCELLANEOUS: UGT1A5 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity. {ECO:0000269|PubMed:18004212}.	cellular glucuronidation [GO:0052695]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]; cellular glucuronidation [GO:0052695]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P22309}; Single-pass membrane protein {ECO:0000255}.
P35520	reviewed	CBS_HUMAN	Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase)	CBS	Homo sapiens (Human)	551	FUNCTION: Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). {ECO:0000250|UniProtKB:P32232, ECO:0000269|PubMed:20506325, ECO:0000269|PubMed:23974653, ECO:0000269|PubMed:23981774}.		blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to hypoxia [GO:0071456]; cerebellum morphogenesis [GO:0021587]; cysteine biosynthetic process [GO:0019344]; cysteine biosynthetic process from serine [GO:0006535]; cysteine biosynthetic process via cystathionine [GO:0019343]; DNA protection [GO:0042262]; endochondral ossification [GO:0001958]; homocysteine catabolic process [GO:0043418]; homocysteine metabolic process [GO:0050667]; hydrogen sulfide biosynthetic process [GO:0070814]; L-cysteine catabolic process [GO:0019448]; L-serine catabolic process [GO:0006565]; L-serine metabolic process [GO:0006563]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of apoptotic process [GO:0043066]; regulation of nitric oxide mediated signal transduction [GO:0010749]; response to folic acid [GO:0051593]; superoxide metabolic process [GO:0006801]; transsulfuration [GO:0019346]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	carbon monoxide binding [GO:0070025]; cystathionine beta-synthase activity [GO:0004122]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; modified amino acid binding [GO:0072341]; nitric oxide binding [GO:0070026]; nitrite reductase (NO-forming) activity [GO:0050421]; oxygen binding [GO:0019825]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; S-adenosyl-L-methionine binding [GO:1904047]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; carbon monoxide binding [GO:0070025]; cystathionine beta-synthase activity [GO:0004122]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; modified amino acid binding [GO:0072341]; nitric oxide binding [GO:0070026]; nitrite reductase (NO-forming) activity [GO:0050421]; oxygen binding [GO:0019825]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; S-adenosyl-L-methionine binding [GO:1904047]; ubiquitin protein ligase binding [GO:0031625]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to hypoxia [GO:0071456]; cerebellum morphogenesis [GO:0021587]; cysteine biosynthetic process [GO:0019344]; cysteine biosynthetic process from serine [GO:0006535]; cysteine biosynthetic process via cystathionine [GO:0019343]; DNA protection [GO:0042262]; endochondral ossification [GO:0001958]; homocysteine catabolic process [GO:0043418]; homocysteine metabolic process [GO:0050667]; hydrogen sulfide biosynthetic process [GO:0070814]; L-cysteine catabolic process [GO:0019448]; L-serine catabolic process [GO:0006565]; L-serine metabolic process [GO:0006563]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of apoptotic process [GO:0043066]; regulation of nitric oxide mediated signal transduction [GO:0010749]; response to folic acid [GO:0051593]; superoxide metabolic process [GO:0006801]; transsulfuration [GO:0019346]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17087506, ECO:0000269|PubMed:23981774}. Nucleus {ECO:0000269|PubMed:17087506}.
P35523	reviewed	CLCN1_HUMAN	Chloride channel protein 1 (ClC-1) (Chloride channel protein, skeletal muscle)	CLCN1 CLC1	Homo sapiens (Human)	988	FUNCTION: Voltage-gated chloride channel (PubMed:8112288, PubMed:9122265, PubMed:12456816). Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (Probable). The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). {ECO:0000269|PubMed:12456816, ECO:0000269|PubMed:22521272, ECO:0000269|PubMed:26007199, ECO:0000269|PubMed:26502825, ECO:0000269|PubMed:26510092, ECO:0000269|PubMed:7951242, ECO:0000269|PubMed:8112288, ECO:0000269|PubMed:9122265, ECO:0000269|PubMed:9736777, ECO:0000305|PubMed:29809153}.		chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; muscle contraction [GO:0006936]; neuronal action potential propagation [GO:0019227]; regulation of monoatomic ion transmembrane transport [GO:0034765]	chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	protein homodimerization activity [GO:0042803]; voltage-gated chloride channel activity [GO:0005247]	chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; protein homodimerization activity [GO:0042803]; voltage-gated chloride channel activity [GO:0005247]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; muscle contraction [GO:0006936]; neuronal action potential propagation [GO:0019227]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12456816, ECO:0000269|PubMed:26502825, ECO:0000269|PubMed:8112288, ECO:0000269|PubMed:9122265}; Multi-pass membrane protein {ECO:0000269|PubMed:29809153}.
P35527	reviewed	K1C9_HUMAN	Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9)	KRT9	Homo sapiens (Human)	623	FUNCTION: May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly. {ECO:0000269|PubMed:10218578, ECO:0000269|PubMed:7507869}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; skin development [GO:0043588]; spermatogenesis [GO:0007283]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634]	structural constituent of cytoskeleton [GO:0005200]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634]; structural constituent of cytoskeleton [GO:0005200]; epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; skin development [GO:0043588]; spermatogenesis [GO:0007283]	
P35548	reviewed	MSX2_HUMAN	Homeobox protein MSX-2 (Homeobox protein Hox-8)	MSX2 HOX8	Homo sapiens (Human)	267	FUNCTION: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:12145306}.		activation of meiosis [GO:0090427]; anterior/posterior pattern specification [GO:0009952]; BMP signaling pathway [GO:0030509]; bone trabecula formation [GO:0060346]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cardiac conduction system development [GO:0003161]; cell surface receptor signaling pathway involved in heart development [GO:0061311]; cellular response to estradiol stimulus [GO:0071392]; chondrocyte development [GO:0002063]; cranial suture morphogenesis [GO:0060363]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic morphogenesis [GO:0048598]; embryonic nail plate morphogenesis [GO:0035880]; enamel mineralization [GO:0070166]; endochondral bone growth [GO:0003416]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; frontal suture morphogenesis [GO:0060364]; mesenchymal cell apoptotic process [GO:0097152]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; osteoblast development [GO:0002076]; osteoblast differentiation [GO:0001649]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of mesenchymal cell apoptotic process [GO:2001055]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of timing of catagen [GO:0051795]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction involved in regulation of gene expression [GO:0023019]; stem cell differentiation [GO:0048863]; wound healing, spreading of epidermal cells [GO:0035313]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; activation of meiosis [GO:0090427]; anterior/posterior pattern specification [GO:0009952]; BMP signaling pathway [GO:0030509]; bone trabecula formation [GO:0060346]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cardiac conduction system development [GO:0003161]; cell surface receptor signaling pathway involved in heart development [GO:0061311]; cellular response to estradiol stimulus [GO:0071392]; chondrocyte development [GO:0002063]; cranial suture morphogenesis [GO:0060363]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic morphogenesis [GO:0048598]; embryonic nail plate morphogenesis [GO:0035880]; enamel mineralization [GO:0070166]; endochondral bone growth [GO:0003416]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; frontal suture morphogenesis [GO:0060364]; mesenchymal cell apoptotic process [GO:0097152]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; osteoblast development [GO:0002076]; osteoblast differentiation [GO:0001649]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of mesenchymal cell apoptotic process [GO:2001055]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of timing of catagen [GO:0051795]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction involved in regulation of gene expression [GO:0023019]; stem cell differentiation [GO:0048863]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: Nucleus.
P35555	reviewed	FBN1_HUMAN	Fibrillin-1 [Cleaved into: Asprosin]	FBN1 FBN	Homo sapiens (Human)	2871	FUNCTION: [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:1860873, PubMed:15062093). Fibrillin-1-containing microfibrils provide long-term force bearing structural support (PubMed:27026396). In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin (PubMed:27026396). In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles (PubMed:27026396). Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11 (PubMed:24039232). This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:11461921, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15062093, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:1860873, ECO:0000269|PubMed:24039232, ECO:0000303|PubMed:27026396}.; FUNCTION: [Asprosin]: Adipokine secreted by white adipose tissue that plays an important regulatory role in the glucose metabolism of liver, muscle and pancreas (PubMed:27087445, PubMed:30853600). Hormone that targets the liver in response to fasting to increase plasma glucose levels (PubMed:27087445). Binds the olfactory receptor OR4M1 at the surface of hepatocytes and promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation (PubMed:27087445, PubMed:31230984). May act as a regulator of adaptive thermogenesis by inhibiting browning and energy consumption, while increasing lipid deposition in white adipose tissue (By similarity). Also acts as an orexigenic hormone that increases appetite: crosses the blood brain barrier and exerts effects on the hypothalamus (By similarity). In the arcuate nucleus of the hypothalamus, asprosin directly activates orexigenic AgRP neurons and indirectly inhibits anorexigenic POMC neurons, resulting in appetite stimulation (By similarity). Activates orexigenic AgRP neurons via binding to the olfactory receptor OR4M1 (By similarity). May also play a role in sperm motility in testis via interaction with OR4M1 receptor (By similarity). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:27087445, ECO:0000269|PubMed:30853600, ECO:0000269|PubMed:31230984}.	MISCELLANEOUS: [Asprosin]: Was named after the Greek word for white, because of the reduction in subcutaneous white adipose tissue that is displayed by asprosin-deficient patients. {ECO:0000303|PubMed:27087445}.	anatomical structure morphogenesis [GO:0009653]; camera-type eye development [GO:0043010]; cell adhesion mediated by integrin [GO:0033627]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic eye morphogenesis [GO:0048048]; heart development [GO:0007507]; metanephros development [GO:0001656]; negative regulation of osteoclast development [GO:2001205]; negative regulation of osteoclast differentiation [GO:0045671]; post-embryonic eye morphogenesis [GO:0048050]; sequestering of BMP in extracellular matrix [GO:0035582]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; skeletal system development [GO:0001501]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527]	calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; protein-containing complex binding [GO:0044877]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527]; calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; protein-containing complex binding [GO:0044877]; anatomical structure morphogenesis [GO:0009653]; camera-type eye development [GO:0043010]; cell adhesion mediated by integrin [GO:0033627]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic eye morphogenesis [GO:0048048]; heart development [GO:0007507]; metanephros development [GO:0001656]; negative regulation of osteoclast development [GO:2001205]; negative regulation of osteoclast differentiation [GO:0045671]; post-embryonic eye morphogenesis [GO:0048050]; sequestering of BMP in extracellular matrix [GO:0035582]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24982166, ECO:0000269|PubMed:34411563}. Note=Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin (PubMed:24982166). {ECO:0000269|PubMed:24982166}.; SUBCELLULAR LOCATION: [Fibrillin-1]: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11461921, ECO:0000269|PubMed:24982166}.; SUBCELLULAR LOCATION: [Asprosin]: Secreted {ECO:0000269|PubMed:27087445}. Note=Secreted by white adipose tissue and circulates in the plasma. {ECO:0000269|PubMed:27087445}.
P35556	reviewed	FBN2_HUMAN	Fibrillin-2 [Cleaved into: Placensin]	FBN2	Homo sapiens (Human)	2912	FUNCTION: [Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. {ECO:0000250|UniProtKB:Q61555}.; FUNCTION: [Placensin]: Hormone secreted by trophoblasts that promotes trophoblast invasiveness (PubMed:32329225). Has glucogenic activity: is able to increase plasma glucose levels (By similarity). {ECO:0000250|UniProtKB:Q61555, ECO:0000269|PubMed:32329225}.		anatomical structure morphogenesis [GO:0009653]; bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]	calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; hormone activity [GO:0005179]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]; calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; hormone activity [GO:0005179]; anatomical structure morphogenesis [GO:0009653]; bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32329225}. Note=Fibrillin-2 and Placensin chains are still linked together during the secretion from cells, but are subsequently separated by furin. {ECO:0000269|PubMed:32329225}.; SUBCELLULAR LOCATION: [Fibrillin-2]: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:8120105}.; SUBCELLULAR LOCATION: [Placensin]: Secreted {ECO:0000269|PubMed:32329225}. Note=Secreted by placental cells. {ECO:0000269|PubMed:32329225}.
P35557	reviewed	HXK4_HUMAN	Hexokinase-4 (HK4) (EC 2.7.1.1) (Glucokinase) (Hexokinase type IV) (HK IV) (Hexokinase-D)	GCK	Homo sapiens (Human)	465	FUNCTION: Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:7742312, PubMed:11916951, PubMed:15277402, PubMed:17082186, PubMed:18322640, PubMed:19146401, PubMed:25015100, PubMed:8325892). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (PubMed:18322640, PubMed:25015100, PubMed:8325892, PubMed:11916951, PubMed:15277402). Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (By similarity). In pancreas, plays an important role in modulating insulin secretion (By similarity). In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (By similarity). Required to provide D-glucose 6-phosphate for the synthesis of glycogen (PubMed:8878425). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:7742312). {ECO:0000250|UniProtKB:P17712, ECO:0000250|UniProtKB:P52792, ECO:0000269|PubMed:11916951, ECO:0000269|PubMed:15277402, ECO:0000269|PubMed:17082186, ECO:0000269|PubMed:18322640, ECO:0000269|PubMed:19146401, ECO:0000269|PubMed:25015100, ECO:0000269|PubMed:7742312, ECO:0000269|PubMed:8325892, ECO:0000269|PubMed:8878425}.		calcium ion import [GO:0070509]; canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; cellular response to insulin stimulus [GO:0032869]; cellular response to leptin stimulus [GO:0044320]; glucose 6-phosphate metabolic process [GO:0051156]; glucose catabolic process [GO:0006007]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]; NADP metabolic process [GO:0006739]; negative regulation of gluconeogenesis [GO:0045721]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin secretion [GO:0032024]; regulation of glycolytic process [GO:0006110]; regulation of insulin secretion [GO:0050796]; regulation of potassium ion transport [GO:0043266]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucose binding [GO:0005536]; mannokinase activity [GO:0019158]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucose binding [GO:0005536]; mannokinase activity [GO:0019158]; calcium ion import [GO:0070509]; canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; cellular response to insulin stimulus [GO:0032869]; cellular response to leptin stimulus [GO:0044320]; glucose 6-phosphate metabolic process [GO:0051156]; glucose catabolic process [GO:0006007]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]; NADP metabolic process [GO:0006739]; negative regulation of gluconeogenesis [GO:0045721]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin secretion [GO:0032024]; regulation of glycolytic process [GO:0006110]; regulation of insulin secretion [GO:0050796]; regulation of potassium ion transport [GO:0043266]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:24187134}. Nucleus {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:24187134}. Mitochondrion {ECO:0000250|UniProtKB:P17712}. Note=Under low glucose concentrations, GCK associates with GCKR and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000269|PubMed:10456334}.
P35558	reviewed	PCKGC_HUMAN	Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) (Serine-protein kinase PCK1) (EC 2.7.11.-)	PCK1 PEPCK1	Homo sapiens (Human)	622	FUNCTION: Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:30193097, PubMed:24863970, PubMed:26971250, PubMed:28216384). Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle (PubMed:30193097, PubMed:24863970, PubMed:26971250, PubMed:28216384). At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:30193097). At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (PubMed:30193097). Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis (By similarity). The resultant phosphoenolpyruvate flows to glycogen and pentose phosphate pathway, which is essential for memory CD8(+) T-cells homeostasis (By similarity). In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor (PubMed:32322062). The protein kinase activity regulates lipogenesis: upon phosphorylation at Ser-90, translocates to the endoplasmic reticulum and catalyzes phosphorylation of INSIG proteins (INSIG1 and INSIG2), thereby disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes (PubMed:32322062). {ECO:0000250|UniProtKB:Q9Z2V4, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26971250, ECO:0000269|PubMed:28216384, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:32322062}.	MISCELLANEOUS: In eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one. {ECO:0000305}.	cellular hyperosmotic salinity response [GO:0071475]; cellular hypotonic salinity response [GO:0071477]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-1 [GO:0071347]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to potassium ion starvation [GO:0051365]; cellular response to raffinose [GO:0097403]; cellular response to retinoic acid [GO:0071300]; cellular response to tumor necrosis factor [GO:0071356]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycerol biosynthetic process from pyruvate [GO:0046327]; hepatocyte differentiation [GO:0070365]; oxaloacetate metabolic process [GO:0006107]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of transcription from RNA polymerase II promoter in response to acidic pH [GO:0061402]; propionate catabolic process [GO:0019543]; regulation of lipid biosynthetic process [GO:0046890]; response to activity [GO:0014823]; response to insulin [GO:0032868]; response to interleukin-6 [GO:0070741]; response to lipopolysaccharide [GO:0032496]; response to methionine [GO:1904640]; response to starvation [GO:0042594]; tricarboxylic acid metabolic process [GO:0072350]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]	carboxylic acid binding [GO:0031406]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613]; protein serine kinase activity (using GTP as donor) [GO:0106264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; carboxylic acid binding [GO:0031406]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613]; protein serine kinase activity (using GTP as donor) [GO:0106264]; cellular hyperosmotic salinity response [GO:0071475]; cellular hypotonic salinity response [GO:0071477]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-1 [GO:0071347]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to potassium ion starvation [GO:0051365]; cellular response to raffinose [GO:0097403]; cellular response to retinoic acid [GO:0071300]; cellular response to tumor necrosis factor [GO:0071356]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycerol biosynthetic process from pyruvate [GO:0046327]; hepatocyte differentiation [GO:0070365]; oxaloacetate metabolic process [GO:0006107]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of transcription from RNA polymerase II promoter in response to acidic pH [GO:0061402]; propionate catabolic process [GO:0019543]; regulation of lipid biosynthetic process [GO:0046890]; response to activity [GO:0014823]; response to insulin [GO:0032868]; response to interleukin-6 [GO:0070741]; response to lipopolysaccharide [GO:0032496]; response to methionine [GO:1904640]; response to starvation [GO:0042594]; tricarboxylic acid metabolic process [GO:0072350]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:32322062}. Endoplasmic reticulum {ECO:0000269|PubMed:32322062}. Note=Phosphorylation at Ser-90 promotes translocation to the endoplasmic reticulum. {ECO:0000269|PubMed:32322062}.
P35568	reviewed	IRS1_HUMAN	Insulin receptor substrate 1 (IRS-1)	IRS1	Homo sapiens (Human)	1242	FUNCTION: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). {ECO:0000250, ECO:0000269|PubMed:16878150}.		cellular response to fatty acid [GO:0071398]; cellular response to insulin stimulus [GO:0032869]; glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of insulin secretion [GO:0046676]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucose import [GO:0046326]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; response to insulin [GO:0032868]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; insulin receptor complex [GO:0005899]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphotyrosine residue binding [GO:0001784]; protein kinase C binding [GO:0005080]; SH2 domain binding [GO:0042169]; signaling receptor complex adaptor activity [GO:0030159]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; insulin receptor complex [GO:0005899]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphotyrosine residue binding [GO:0001784]; protein kinase C binding [GO:0005080]; SH2 domain binding [GO:0042169]; signaling receptor complex adaptor activity [GO:0030159]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; cellular response to fatty acid [GO:0071398]; cellular response to insulin stimulus [GO:0032869]; glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of insulin secretion [GO:0046676]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucose import [GO:0046326]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; response to insulin [GO:0032868]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]	
P35573	reviewed	GDE_HUMAN	Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]	AGL GDE	Homo sapiens (Human)	1532	FUNCTION: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.	MISCELLANEOUS: [Isoform 1]: The products of the mRNAs termed isoforms 1 to 4 are identical.	glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; inclusion body [GO:0016234]; isoamylase complex [GO:0043033]; nucleus [GO:0005634]; sarcoplasmic reticulum [GO:0016529]; secretory granule lumen [GO:0034774]	4-alpha-glucanotransferase activity [GO:0004134]; amylo-alpha-1,6-glucosidase activity [GO:0004135]; beta-maltose 4-alpha-glucanotransferase activity [GO:0102500]; glycogen debranching enzyme activity [GO:0004133]; polysaccharide binding [GO:0030247]; polyubiquitin modification-dependent protein binding [GO:0031593]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; inclusion body [GO:0016234]; isoamylase complex [GO:0043033]; nucleus [GO:0005634]; sarcoplasmic reticulum [GO:0016529]; secretory granule lumen [GO:0034774]; 4-alpha-glucanotransferase activity [GO:0004134]; amylo-alpha-1,6-glucosidase activity [GO:0004135]; beta-maltose 4-alpha-glucanotransferase activity [GO:0102500]; glycogen debranching enzyme activity [GO:0004133]; polysaccharide binding [GO:0030247]; polyubiquitin modification-dependent protein binding [GO:0031593]; glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17908927}. Note=Under glycogenolytic conditions localizes to the nucleus.
P35575	reviewed	G6PC1_HUMAN	Glucose-6-phosphatase catalytic subunit 1 (EC 3.1.3.9) (Glucose-6-phosphatase) (G-6-Pase) (G6Pase) (Glucose-6-phosphatase alpha) (G6Pase-alpha)	G6PC1 G6PC G6PT	Homo sapiens (Human)	357	FUNCTION: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. {ECO:0000269|PubMed:10960498, ECO:0000269|PubMed:12093795, ECO:0000269|PubMed:15542400, ECO:0000269|PubMed:9332655, ECO:0000269|PubMed:9497333}.		cholesterol homeostasis [GO:0042632]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose homeostasis [GO:0042593]; glucose-6-phosphate transport [GO:0015760]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; multicellular organism growth [GO:0035264]; regulation of gene expression [GO:0010468]; steroid metabolic process [GO:0008202]; triglyceride metabolic process [GO:0006641]; urate metabolic process [GO:0046415]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	glucose-6-phosphatase activity [GO:0004346]; phosphate ion binding [GO:0042301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; glucose-6-phosphatase activity [GO:0004346]; phosphate ion binding [GO:0042301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; cholesterol homeostasis [GO:0042632]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose homeostasis [GO:0042593]; glucose-6-phosphate transport [GO:0015760]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; multicellular organism growth [GO:0035264]; regulation of gene expression [GO:0010468]; steroid metabolic process [GO:0008202]; triglyceride metabolic process [GO:0006641]; urate metabolic process [GO:0046415]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000303|PubMed:9497333}; Multi-pass membrane protein {ECO:0000255}.
P35579	reviewed	MYH9_HUMAN	Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)	MYH9	Homo sapiens (Human)	1960	FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.		actin cytoskeleton organization [GO:0030036]; actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cortical granule exocytosis [GO:0060471]; cytokinetic process [GO:0032506]; establishment of meiotic spindle localization [GO:0051295]; establishment of T cell polarity [GO:0001768]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; lysosome localization [GO:0032418]; meiotic spindle organization [GO:0000212]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte differentiation [GO:0030224]; myoblast fusion [GO:0007520]; negative regulation of actin filament severing [GO:1903919]; phagocytosis, engulfment [GO:0006911]; plasma membrane repair [GO:0001778]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of protein processing in phagocytic vesicle [GO:1903923]; protein transport [GO:0015031]; regulated exocytosis [GO:0045055]; regulation of cell shape [GO:0008360]; regulation of plasma membrane repair [GO:1905684]; uropod organization [GO:0032796]	actin cytoskeleton [GO:0015629]; actomyosin [GO:0042641]; actomyosin contractile ring [GO:0005826]; adherens junction [GO:0005912]; brush border [GO:0005903]; cell leading edge [GO:0031252]; cleavage furrow [GO:0032154]; cortical granule [GO:0060473]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; neuromuscular junction [GO:0031594]; nuclear body [GO:0016604]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; spindle [GO:0005819]; stress fiber [GO:0001725]; uropod [GO:0001931]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; cytoskeletal motor activity [GO:0003774]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; RNA binding [GO:0003723]	actin cytoskeleton [GO:0015629]; actomyosin [GO:0042641]; actomyosin contractile ring [GO:0005826]; adherens junction [GO:0005912]; brush border [GO:0005903]; cell leading edge [GO:0031252]; cleavage furrow [GO:0032154]; cortical granule [GO:0060473]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; neuromuscular junction [GO:0031594]; nuclear body [GO:0016604]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; spindle [GO:0005819]; stress fiber [GO:0001725]; uropod [GO:0001931]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; cytoskeletal motor activity [GO:0003774]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; RNA binding [GO:0003723]; actin cytoskeleton organization [GO:0030036]; actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cortical granule exocytosis [GO:0060471]; cytokinetic process [GO:0032506]; establishment of meiotic spindle localization [GO:0051295]; establishment of T cell polarity [GO:0001768]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; lysosome localization [GO:0032418]; meiotic spindle organization [GO:0000212]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte differentiation [GO:0030224]; myoblast fusion [GO:0007520]; negative regulation of actin filament severing [GO:1903919]; phagocytosis, engulfment [GO:0006911]; plasma membrane repair [GO:0001778]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of protein processing in phagocytic vesicle [GO:1903923]; protein transport [GO:0015031]; regulated exocytosis [GO:0045055]; regulation of cell shape [GO:0008360]; regulation of plasma membrane repair [GO:1905684]; uropod organization [GO:0032796]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22693546}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q8VDD5}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8VDD5}. Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610). {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:27331610}.
P35580	reviewed	MYH10_HUMAN	Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)	MYH10	Homo sapiens (Human)	1976	FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.		actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; cell adhesion [GO:0007155]; mitotic cytokinesis [GO:0000281]; positive regulation of protein secretion [GO:0050714]; regulation of cell shape [GO:0008360]	actomyosin [GO:0042641]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; midbody [GO:0030496]; myosin complex [GO:0016459]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; nucleus [GO:0005634]; polysome [GO:0005844]; stress fiber [GO:0001725]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; mRNA 5'-UTR binding [GO:0048027]; RNA stem-loop binding [GO:0035613]	actomyosin [GO:0042641]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; midbody [GO:0030496]; myosin complex [GO:0016459]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; nucleus [GO:0005634]; polysome [GO:0005844]; stress fiber [GO:0001725]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; mRNA 5'-UTR binding [GO:0048027]; RNA stem-loop binding [GO:0035613]; actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; cell adhesion [GO:0007155]; mitotic cytokinesis [GO:0000281]; positive regulation of protein secretion [GO:0050714]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:22480440}. Note=Colocalizes with MCC at the leading edge of migrating cells.
P35590	reviewed	TIE1_HUMAN	Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1)	TIE1 TIE	Homo sapiens (Human)	1138	FUNCTION: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. {ECO:0000269|PubMed:20227369}.		angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; branching involved in lymph vessel morphogenesis [GO:0060854]; in utero embryonic development [GO:0001701]; lymphatic endothelial cell differentiation [GO:0060836]; mesoderm development [GO:0007498]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; phosphorylation [GO:0016310]; plasma membrane fusion [GO:0045026]; positive regulation of angiogenesis [GO:0045766]; regulation of endothelial cell proliferation [GO:0001936]; regulation of extracellular matrix assembly [GO:1901201]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]; tissue remodeling [GO:0048771]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasculogenesis [GO:0001570]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; branching involved in lymph vessel morphogenesis [GO:0060854]; in utero embryonic development [GO:0001701]; lymphatic endothelial cell differentiation [GO:0060836]; mesoderm development [GO:0007498]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; phosphorylation [GO:0016310]; plasma membrane fusion [GO:0045026]; positive regulation of angiogenesis [GO:0045766]; regulation of endothelial cell proliferation [GO:0001936]; regulation of extracellular matrix assembly [GO:1901201]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]; tissue remodeling [GO:0048771]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:20227369}; Single-pass type I membrane protein {ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:20227369}.
P35606	reviewed	COPB2_HUMAN	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102)	COPB2	Homo sapiens (Human)	906	FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]	structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]; structural molecule activity [GO:0005198]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi. {ECO:0000250}.
P35609	reviewed	ACTN2_HUMAN	Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)	ACTN2	Homo sapiens (Human)	894	FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.		actin cytoskeleton organization [GO:0030036]; actin filament uncapping [GO:0051695]; cardiac muscle cell development [GO:0055013]; cell adhesion [GO:0007155]; focal adhesion assembly [GO:0048041]; microspike assembly [GO:0030035]; muscle cell development [GO:0055001]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of protein localization to cell surface [GO:2000009]; phospholipase C-activating angiotensin-activated signaling pathway [GO:0086097]; positive regulation of cation channel activity [GO:2001259]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to plasma membrane [GO:0072659]; regulation of apoptotic process [GO:0042981]; regulation of membrane potential [GO:0042391]; sarcomere organization [GO:0045214]	actin filament [GO:0005884]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; platelet alpha granule lumen [GO:0031093]; postsynaptic actin cytoskeleton [GO:0098871]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]; pseudopodium [GO:0031143]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; cytoskeletal protein binding [GO:0008092]; FATZ binding [GO:0051373]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; LIM domain binding [GO:0030274]; nuclear receptor coactivator activity [GO:0030374]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein domain specific binding [GO:0019904]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]; titin Z domain binding [GO:0070080]; transmembrane transporter binding [GO:0044325]	actin filament [GO:0005884]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; platelet alpha granule lumen [GO:0031093]; postsynaptic actin cytoskeleton [GO:0098871]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]; pseudopodium [GO:0031143]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; cytoskeletal protein binding [GO:0008092]; FATZ binding [GO:0051373]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; LIM domain binding [GO:0030274]; nuclear receptor coactivator activity [GO:0030374]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein domain specific binding [GO:0019904]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]; titin Z domain binding [GO:0070080]; transmembrane transporter binding [GO:0044325]; actin cytoskeleton organization [GO:0030036]; actin filament uncapping [GO:0051695]; cardiac muscle cell development [GO:0055013]; cell adhesion [GO:0007155]; focal adhesion assembly [GO:0048041]; microspike assembly [GO:0030035]; muscle cell development [GO:0055001]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of protein localization to cell surface [GO:2000009]; phospholipase C-activating angiotensin-activated signaling pathway [GO:0086097]; positive regulation of cation channel activity [GO:2001259]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to plasma membrane [GO:0072659]; regulation of apoptotic process [GO:0042981]; regulation of membrane potential [GO:0042391]; sarcomere organization [GO:0045214]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11171996, ECO:0000269|PubMed:19932097, ECO:0000269|PubMed:30701273}. Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
P35610	reviewed	SOAT1_HUMAN	Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)	SOAT1 ACACT ACACT1 ACAT ACAT1 SOAT STAT	Homo sapiens (Human)	550	FUNCTION: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:9020103, PubMed:32433614, PubMed:32433613, PubMed:32944968). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614). {ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0000269|PubMed:32944968, ECO:0000269|PubMed:9020103}.		cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; low-density lipoprotein particle clearance [GO:0034383]; macrophage derived foam cell differentiation [GO:0010742]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; very-low-density lipoprotein particle assembly [GO:0034379]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	cholesterol binding [GO:0015485]; cholesterol O-acyltransferase activity [GO:0034736]; fatty-acyl-CoA binding [GO:0000062]; identical protein binding [GO:0042802]; sterol O-acyltransferase activity [GO:0004772]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; cholesterol binding [GO:0015485]; cholesterol O-acyltransferase activity [GO:0034736]; fatty-acyl-CoA binding [GO:0000062]; identical protein binding [GO:0042802]; sterol O-acyltransferase activity [GO:0004772]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; low-density lipoprotein particle clearance [GO:0034383]; macrophage derived foam cell differentiation [GO:0010742]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; very-low-density lipoprotein particle assembly [GO:0034379]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10438503, ECO:0000269|PubMed:16154994}; Multi-pass membrane protein {ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614}.
P35611	reviewed	ADDA_HUMAN	Alpha-adducin (Erythrocyte adducin subunit alpha)	ADD1 ADDA	Homo sapiens (Human)	737	FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.		actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; barbed-end actin filament capping [GO:0051016]; cellular response to calcium ion [GO:0071277]; positive regulation of adherens junction organization [GO:1903393]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of protein binding [GO:0032092]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; spectrin binding [GO:0030507]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; spectrin binding [GO:0030507]; actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; barbed-end actin filament capping [GO:0051016]; cellular response to calcium ion [GO:0071277]; positive regulation of adherens junction organization [GO:1903393]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of protein binding [GO:0032092]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
P35612	reviewed	ADDB_HUMAN	Beta-adducin (Erythrocyte adducin subunit beta)	ADD2 ADDB	Homo sapiens (Human)	726	FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}.		actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; barbed-end actin filament capping [GO:0051016]; hemopoiesis [GO:0030097]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]; positive regulation of protein binding [GO:0032092]; protein-containing complex assembly [GO:0065003]; synapse assembly [GO:0007416]	cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]	cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; barbed-end actin filament capping [GO:0051016]; hemopoiesis [GO:0030097]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]; positive regulation of protein binding [GO:0032092]; protein-containing complex assembly [GO:0065003]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
P35613	reviewed	BASI_HUMAN	Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)	BSG UNQ6505/PRO21383	Homo sapiens (Human)	385	FUNCTION: [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11943775, PubMed:11688976). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:12553375, PubMed:11992541, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}.	MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000269|PubMed:21536654}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative promoter usage. {ECO:0000269|PubMed:21536654}.	angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; endothelial tube morphogenesis [GO:0061154]; neural retina development [GO:0003407]; neutrophil chemotaxis [GO:0030593]; odontogenesis of dentin-containing tooth [GO:0042475]; photoreceptor cell maintenance [GO:0045494]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of viral entry into host cell [GO:0046598]; protein localization to plasma membrane [GO:0072659]; response to cAMP [GO:0051591]; response to mercury ion [GO:0046689]; response to peptide hormone [GO:0043434]	acrosomal membrane [GO:0002080]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	cadherin binding [GO:0045296]; mannose binding [GO:0005537]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618]	acrosomal membrane [GO:0002080]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; cadherin binding [GO:0045296]; mannose binding [GO:0005537]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618]; angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; endothelial tube morphogenesis [GO:0061154]; neural retina development [GO:0003407]; neutrophil chemotaxis [GO:0030593]; odontogenesis of dentin-containing tooth [GO:0042475]; photoreceptor cell maintenance [GO:0045494]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of viral entry into host cell [GO:0046598]; protein localization to plasma membrane [GO:0072659]; response to cAMP [GO:0051591]; response to mercury ion [GO:0046689]; response to peptide hormone [GO:0043434]	SUBCELLULAR LOCATION: Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:25957687}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P18572}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P18572}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:15688292, ECO:0000269|PubMed:15946952, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:21536654, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866, ECO:0000269|PubMed:29739904}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Endosome {ECO:0000269|PubMed:29739904}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15688292}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Basolateral cell membrane {ECO:0000269|PubMed:17267690}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:21536654}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:21536654}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.
P35625	reviewed	TIMP3_HUMAN	Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3)	TIMP3	Homo sapiens (Human)	211	FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.		cellular response to organic substance [GO:0071310]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of metalloendopeptidase activity [GO:1904684]; positive regulation of TRAIL-activated apoptotic signaling pathway [GO:1903984]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; visual perception [GO:0007601]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; platelet dense granule lumen [GO:0031089]	metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; platelet dense granule lumen [GO:0031089]; metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020]; cellular response to organic substance [GO:0071310]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of metalloendopeptidase activity [GO:1904684]; positive regulation of TRAIL-activated apoptotic signaling pathway [GO:1903984]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
P35626	reviewed	ARBK2_HUMAN	Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (EC 2.7.11.15) (G-protein-coupled receptor kinase 3)	GRK3 ADRBK2 BARK2	Homo sapiens (Human)	688	FUNCTION: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. {ECO:0000250|UniProtKB:P26819}.		desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled receptor signaling pathway [GO:0007186]; phosphorylation [GO:0016310]; receptor internalization [GO:0031623]; signal transduction [GO:0007165]	cell projection [GO:0042995]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]	ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled receptor kinase activity [GO:0004703]; protein kinase activity [GO:0004672]	cell projection [GO:0042995]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled receptor kinase activity [GO:0004703]; protein kinase activity [GO:0004672]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled receptor signaling pathway [GO:0007186]; phosphorylation [GO:0016310]; receptor internalization [GO:0031623]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Postsynapse {ECO:0000250|UniProtKB:P26819}. Presynapse {ECO:0000250|UniProtKB:P26819}.
P35637	reviewed	FUS_HUMAN	RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)	FUS TLS	Homo sapiens (Human)	526	FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.		amyloid fibril formation [GO:1990000]; mRNA stabilization [GO:0048255]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; protein homooligomerization [GO:0051260]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; intracellular non-membrane-bounded organelle [GO:0043232]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	cytoplasm [GO:0005737]; intracellular non-membrane-bounded organelle [GO:0043232]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; amyloid fibril formation [GO:1990000]; mRNA stabilization [GO:0048255]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; protein homooligomerization [GO:0051260]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19251627, ECO:0000269|PubMed:19251628, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:25453086, ECO:0000269|PubMed:30354839}. Note=Displays a punctate pattern inside the nucleus and is excluded from nucleoli. {ECO:0000269|PubMed:25453086}.
P35638	reviewed	DDIT3_HUMAN	DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153)	DDIT3 CHOP CHOP10 GADD153	Homo sapiens (Human)	169	FUNCTION: Multifunctional transcription factor in endoplasmic reticulum (ER) stress response (PubMed:15322075, PubMed:15775988, PubMed:19672300). Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress (PubMed:15322075, PubMed:15775988). Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes (By similarity). Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes (By similarity). Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L (PubMed:15775988, PubMed:17709599, PubMed:22761832, PubMed:20876114). Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:18940792, PubMed:19672300, PubMed:20829347). Together with ATF4, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress (By similarity). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity (PubMed:16434966). Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (By similarity). Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling (By similarity). {ECO:0000250|UniProtKB:P35639, ECO:0000269|PubMed:15322075, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16434966, ECO:0000269|PubMed:17709599, ECO:0000269|PubMed:18940792, ECO:0000269|PubMed:19672300, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:20876114, ECO:0000269|PubMed:22761832}.		anterior/posterior axis specification [GO:0009948]; artery development [GO:0060840]; ATF6-mediated unfolded protein response [GO:0036500]; blood vessel maturation [GO:0001955]; cell cycle [GO:0007049]; cell redox homeostasis [GO:0045454]; DNA damage response [GO:0006974]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; establishment of protein localization to mitochondrion [GO:0072655]; gene expression [GO:0010467]; integrated stress response signaling [GO:0140467]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to nitrosative stress [GO:1990442]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of determination of dorsal identity [GO:2000016]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of autophagy [GO:0010506]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to stress [GO:0043618]; release of sequestered calcium ion into cytosol [GO:0051209]; response to endoplasmic reticulum stress [GO:0034976]; response to platelet-derived growth factor [GO:0036119]; response to starvation [GO:0042594]; response to unfolded protein [GO:0006986]; response to wounding [GO:0009611]; sensory perception of sound [GO:0007605]; vascular associated smooth muscle cell migration [GO:1904738]; vascular associated smooth muscle cell proliferation [GO:1990874]; Wnt signaling pathway [GO:0016055]	CHOP-ATF3 complex [GO:1990622]; CHOP-ATF4 complex [GO:1990617]; CHOP-C/EBP complex [GO:0036488]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; late endosome [GO:0005770]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	cAMP response element binding protein binding [GO:0008140]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription regulator inhibitor activity [GO:0140416]	CHOP-ATF3 complex [GO:1990622]; CHOP-ATF4 complex [GO:1990617]; CHOP-C/EBP complex [GO:0036488]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; late endosome [GO:0005770]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]; cAMP response element binding protein binding [GO:0008140]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription regulator inhibitor activity [GO:0140416]; anterior/posterior axis specification [GO:0009948]; artery development [GO:0060840]; ATF6-mediated unfolded protein response [GO:0036500]; blood vessel maturation [GO:0001955]; cell cycle [GO:0007049]; cell redox homeostasis [GO:0045454]; DNA damage response [GO:0006974]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; establishment of protein localization to mitochondrion [GO:0072655]; gene expression [GO:0010467]; integrated stress response signaling [GO:0140467]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to nitrosative stress [GO:1990442]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of determination of dorsal identity [GO:2000016]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of autophagy [GO:0010506]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to stress [GO:0043618]; release of sequestered calcium ion into cytosol [GO:0051209]; response to endoplasmic reticulum stress [GO:0034976]; response to platelet-derived growth factor [GO:0036119]; response to starvation [GO:0042594]; response to unfolded protein [GO:0006986]; response to wounding [GO:0009611]; sensory perception of sound [GO:0007605]; vascular associated smooth muscle cell migration [GO:1904738]; vascular associated smooth muscle cell proliferation [GO:1990874]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29083303}. Nucleus {ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:33384352}. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. {ECO:0000269|PubMed:29083303}.
P35658	reviewed	NU214_HUMAN	Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN)	NUP214 CAIN CAN KIAA0023	Homo sapiens (Human)	2090	FUNCTION: Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}.		mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; regulation of cell cycle [GO:0051726]; regulation of nucleocytoplasmic transport [GO:0046822]; RNA export from nucleus [GO:0006405]	cytoplasmic side of nuclear pore [GO:1990876]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]	nuclear export signal receptor activity [GO:0005049]; nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]	cytoplasmic side of nuclear pore [GO:1990876]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nuclear export signal receptor activity [GO:0005049]; nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; regulation of cell cycle [GO:0051726]; regulation of nucleocytoplasmic transport [GO:0046822]; RNA export from nucleus [GO:0006405]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:8108440}. Note=Cytoplasmic side of the nuclear pore complex. {ECO:0000269|PubMed:8108440}.
P35659	reviewed	DEK_HUMAN	Protein DEK	DEK	Homo sapiens (Human)	375	FUNCTION: Involved in chromatin organization. {ECO:0000269|PubMed:17524367}.		chromatin remodeling [GO:0006338]; positive regulation of histone acetylation [GO:0035066]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]; viral genome replication [GO:0019079]	B-WICH complex [GO:0110016]; contractile fiber [GO:0043292]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone binding [GO:0042393]; RNA binding [GO:0003723]	B-WICH complex [GO:0110016]; contractile fiber [GO:0043292]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone binding [GO:0042393]; RNA binding [GO:0003723]; chromatin remodeling [GO:0006338]; positive regulation of histone acetylation [GO:0035066]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]; viral genome replication [GO:0019079]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17524367, ECO:0000269|PubMed:19695025}. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
P35670	reviewed	ATP7B_HUMAN	Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa]	ATP7B PWD WC1 WND	Homo sapiens (Human)	1465	FUNCTION: Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}.	MISCELLANEOUS: [Isoform 5]: May arise by a -1 programmed ribosomal frameshift at codon 233. A nucleotide 'slippery sequence' followed by an mRNA pseudoknot are found downstream of the frameshift site and direct frameshifting of a gene fragment with about 10% efficiency. {ECO:0000305|PubMed:28107647}.	copper ion export [GO:0060003]; copper ion import [GO:0015677]; copper ion transport [GO:0006825]; establishment of localization in cell [GO:0051649]; intracellular copper ion homeostasis [GO:0006878]; intracellular zinc ion homeostasis [GO:0006882]; lactation [GO:0007595]; monoatomic ion transmembrane transport [GO:0034220]; protein maturation by copper ion transfer [GO:0015680]; response to copper ion [GO:0046688]; sequestering of calcium ion [GO:0051208]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; P-type divalent copper transporter activity [GO:0043682]; P-type monovalent copper transporter activity [GO:0140581]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; P-type divalent copper transporter activity [GO:0043682]; P-type monovalent copper transporter activity [GO:0140581]; copper ion export [GO:0060003]; copper ion import [GO:0015677]; copper ion transport [GO:0006825]; establishment of localization in cell [GO:0051649]; intracellular copper ion homeostasis [GO:0006878]; intracellular zinc ion homeostasis [GO:0006882]; lactation [GO:0007595]; monoatomic ion transmembrane transport [GO:0034220]; protein maturation by copper ion transfer [GO:0015680]; response to copper ion [GO:0046688]; sequestering of calcium ion [GO:0051208]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:17919502, ECO:0000269|PubMed:19033537, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876}; Multi-pass membrane protein {ECO:0000255}. Late endosome {ECO:0000269|PubMed:11231950, ECO:0000269|PubMed:15681833}. Note=Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420). {ECO:0000269|PubMed:10942420, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:9307043}.; SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:9307043}; Multi-pass membrane protein {ECO:0000269|PubMed:9307043}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:9307043}.; SUBCELLULAR LOCATION: [WND/140 kDa]: Mitochondrion {ECO:0000269|PubMed:9600907}.
P35680	reviewed	HNF1B_HUMAN	Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1)	HNF1B TCF2	Homo sapiens (Human)	557	FUNCTION: Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:7900999, PubMed:17924661). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (PubMed:24204001). {ECO:0000250|UniProtKB:Q03365, ECO:0000269|PubMed:17924661, ECO:0000269|PubMed:24204001, ECO:0000269|PubMed:7900999}.		anterior/posterior pattern specification [GO:0009952]; branching morphogenesis of an epithelial tube [GO:0048754]; embryonic digestive tract morphogenesis [GO:0048557]; endocrine pancreas development [GO:0031018]; endodermal cell fate specification [GO:0001714]; epithelial cell proliferation [GO:0050673]; genitalia development [GO:0048806]; hepatoblast differentiation [GO:0061017]; hindbrain development [GO:0030902]; inner cell mass cell differentiation [GO:0001826]; insulin secretion [GO:0030073]; kidney development [GO:0001822]; mesenchymal cell apoptotic process involved in metanephros development [GO:1900200]; mesonephric duct formation [GO:0072181]; negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis [GO:0061296]; negative regulation of mesenchymal cell apoptotic process involved in metanephros development [GO:1900212]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; pancreas development [GO:0031016]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; pronephric nephron tubule development [GO:0039020]; pronephros development [GO:0048793]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of pronephros size [GO:0035565]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]; response to glucose [GO:0009749]; ureteric bud elongation [GO:0060677]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator binding [GO:0001221]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator binding [GO:0001221]; anterior/posterior pattern specification [GO:0009952]; branching morphogenesis of an epithelial tube [GO:0048754]; embryonic digestive tract morphogenesis [GO:0048557]; endocrine pancreas development [GO:0031018]; endodermal cell fate specification [GO:0001714]; epithelial cell proliferation [GO:0050673]; genitalia development [GO:0048806]; hepatoblast differentiation [GO:0061017]; hindbrain development [GO:0030902]; inner cell mass cell differentiation [GO:0001826]; insulin secretion [GO:0030073]; kidney development [GO:0001822]; mesenchymal cell apoptotic process involved in metanephros development [GO:1900200]; mesonephric duct formation [GO:0072181]; negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis [GO:0061296]; negative regulation of mesenchymal cell apoptotic process involved in metanephros development [GO:1900212]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; pancreas development [GO:0031016]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; pronephric nephron tubule development [GO:0039020]; pronephros development [GO:0048793]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of pronephros size [GO:0035565]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]; response to glucose [GO:0009749]; ureteric bud elongation [GO:0060677]	SUBCELLULAR LOCATION: Nucleus.
P35711	reviewed	SOX5_HUMAN	Transcription factor SOX-5	SOX5	Homo sapiens (Human)	763	FUNCTION: Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. {ECO:0000250|UniProtKB:P35710}.		asymmetric neuroblast division [GO:0055059]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte differentiation [GO:0002062]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; asymmetric neuroblast division [GO:0055059]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte differentiation [GO:0002062]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P35710}.
P35712	reviewed	SOX6_HUMAN	Transcription factor SOX-6	SOX6	Homo sapiens (Human)	828	FUNCTION: Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}.		brain development [GO:0007420]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system development [GO:0007417]; chondrocyte differentiation [GO:0002062]; muscle organ development [GO:0007517]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord oligodendrocyte cell differentiation [GO:0021529]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; brain development [GO:0007420]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system development [GO:0007417]; chondrocyte differentiation [GO:0002062]; muscle organ development [GO:0007517]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord oligodendrocyte cell differentiation [GO:0021529]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:16442531}. Cytoplasm {ECO:0000250|UniProtKB:P40645}.
P35713	reviewed	SOX18_HUMAN	Transcription factor SOX-18	SOX18	Homo sapiens (Human)	384	FUNCTION: Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development. {ECO:0000250|UniProtKB:P43680}.		angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cell maturation [GO:0048469]; embryonic heart tube development [GO:0035050]; endocardial cell differentiation [GO:0060956]; endocardium formation [GO:0060214]; establishment of endothelial barrier [GO:0061028]; hair cycle process [GO:0022405]; hair follicle development [GO:0001942]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stem cell proliferation [GO:0072091]; stem cell fate specification [GO:0048866]; vasculature development [GO:0001944]; vasculogenesis [GO:0001570]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cell maturation [GO:0048469]; embryonic heart tube development [GO:0035050]; endocardial cell differentiation [GO:0060956]; endocardium formation [GO:0060214]; establishment of endothelial barrier [GO:0061028]; hair cycle process [GO:0022405]; hair follicle development [GO:0001942]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stem cell proliferation [GO:0072091]; stem cell fate specification [GO:0048866]; vasculature development [GO:0001944]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
P35716	reviewed	SOX11_HUMAN	Transcription factor SOX-11	SOX11	Homo sapiens (Human)	441	FUNCTION: Transcription factor that acts as a transcriptional activator (PubMed:24886874, PubMed:26543203). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). {ECO:0000250|UniProtKB:Q7M6Y2, ECO:0000269|PubMed:24886874, ECO:0000269|PubMed:26543203}.		anatomical structure morphogenesis [GO:0009653]; closure of optic fissure [GO:0061386]; cornea development in camera-type eye [GO:0061303]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic skeletal system morphogenesis [GO:0048704]; eyelid development in camera-type eye [GO:0061029]; glial cell proliferation [GO:0014009]; hard palate development [GO:0060022]; kidney development [GO:0001822]; lens morphogenesis in camera-type eye [GO:0002089]; lung morphogenesis [GO:0060425]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of lymphocyte proliferation [GO:0050672]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; nervous system development [GO:0007399]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; noradrenergic neuron differentiation [GO:0003357]; oligodendrocyte development [GO:0014003]; outflow tract morphogenesis [GO:0003151]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of gene expression [GO:0010628]; positive regulation of hippo signaling [GO:0035332]; positive regulation of hormone secretion [GO:0046887]; positive regulation of lens epithelial cell proliferation [GO:2001111]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; skeletal muscle cell differentiation [GO:0035914]; soft palate development [GO:0060023]; spinal cord development [GO:0021510]; sympathetic nervous system development [GO:0048485]; ventricular septum morphogenesis [GO:0060412]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; closure of optic fissure [GO:0061386]; cornea development in camera-type eye [GO:0061303]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic skeletal system morphogenesis [GO:0048704]; eyelid development in camera-type eye [GO:0061029]; glial cell proliferation [GO:0014009]; hard palate development [GO:0060022]; kidney development [GO:0001822]; lens morphogenesis in camera-type eye [GO:0002089]; lung morphogenesis [GO:0060425]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of lymphocyte proliferation [GO:0050672]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; nervous system development [GO:0007399]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; noradrenergic neuron differentiation [GO:0003357]; oligodendrocyte development [GO:0014003]; outflow tract morphogenesis [GO:0003151]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of gene expression [GO:0010628]; positive regulation of hippo signaling [GO:0035332]; positive regulation of hormone secretion [GO:0046887]; positive regulation of lens epithelial cell proliferation [GO:2001111]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; skeletal muscle cell differentiation [GO:0035914]; soft palate development [GO:0060023]; spinal cord development [GO:0021510]; sympathetic nervous system development [GO:0048485]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:24886874, ECO:0000269|PubMed:35938035}.
P35749	reviewed	MYH11_HUMAN	Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)	MYH11 KIAA0866	Homo sapiens (Human)	1972	FUNCTION: Muscle contraction.	MISCELLANEOUS: [Isoform 2]: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles. {ECO:0000305}.	actomyosin structure organization [GO:0031032]; cardiac muscle cell development [GO:0055013]; elastic fiber assembly [GO:0048251]; skeletal muscle myosin thick filament assembly [GO:0030241]; smooth muscle contraction [GO:0006939]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; structural constituent of muscle [GO:0008307]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; structural constituent of muscle [GO:0008307]; actomyosin structure organization [GO:0031032]; cardiac muscle cell development [GO:0055013]; elastic fiber assembly [GO:0048251]; skeletal muscle myosin thick filament assembly [GO:0030241]; smooth muscle contraction [GO:0006939]	SUBCELLULAR LOCATION: Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
P35754	reviewed	GLRX1_HUMAN	Glutaredoxin-1 (Thioltransferase-1) (TTase-1)	GLRX GRX	Homo sapiens (Human)	106	FUNCTION: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.		nucleobase-containing small molecule interconversion [GO:0015949]; positive regulation of membrane potential [GO:0045838]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; protein deglutathionylation [GO:0080058]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	glutathione disulfide oxidoreductase activity [GO:0015038]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; glutathione disulfide oxidoreductase activity [GO:0015038]; nucleobase-containing small molecule interconversion [GO:0015949]; positive regulation of membrane potential [GO:0045838]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; protein deglutathionylation [GO:0080058]	SUBCELLULAR LOCATION: Cytoplasm.
P35789	reviewed	ZNF93_HUMAN	Zinc finger protein 93 (Zinc finger protein 505) (Zinc finger protein HTF34)	ZNF93 ZNF505	Homo sapiens (Human)	620	FUNCTION: Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305). {ECO:0000269|PubMed:25274305}.	MISCELLANEOUS: ZNF93 is only present in primates and evolved to repress the primate L1 lineage until 12.5 million years. Evolution stopped when the L1PA3-subfamily of retrotransposons, that escape repression by ZNF93 through the removal of the ZNF93-binding site, appeared (PubMed:25274305). {ECO:0000269|PubMed:25274305}.; MISCELLANEOUS: Confers resistance to ET-743 (trabectedin, Yondelis) and PM00104 (Zalypsis), 2 marine derived compounds with antitumor activity in cancer cell lines. {ECO:0000305|PubMed:19742314}.	regulation of transcription by RNA polymerase II [GO:0006357]; retrotransposon silencing [GO:0010526]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of transcription by RNA polymerase II [GO:0006357]; retrotransposon silencing [GO:0010526]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P35790	reviewed	CHKA_HUMAN	Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82)	CHKA CHK CKI	Homo sapiens (Human)	457	FUNCTION: Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis (PubMed:19915674, PubMed:34077757, PubMed:17007874). Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis (PubMed:19915674, PubMed:17007874). Has higher activity with choline (PubMed:19915674, PubMed:17007874). May contribute to tumor cell growth (PubMed:19915674). {ECO:0000269|PubMed:17007874, ECO:0000269|PubMed:19915674, ECO:0000269|PubMed:34077757}.; FUNCTION: [Isoform 1]: This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation (PubMed:34077757). In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets (PubMed:34077757). Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer (PubMed:34077757). Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets (PubMed:34077757). {ECO:0000269|PubMed:34077757}.		CDP-choline pathway [GO:0006657]; cellular response to glucose starvation [GO:0042149]; lipid droplet disassembly [GO:1905691]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]	ATP binding [GO:0005524]; choline kinase activity [GO:0004103]; cholinesterase activity [GO:0004104]; ethanolamine kinase activity [GO:0004305]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; ATP binding [GO:0005524]; choline kinase activity [GO:0004103]; cholinesterase activity [GO:0004104]; ethanolamine kinase activity [GO:0004305]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; CDP-choline pathway [GO:0006657]; cellular response to glucose starvation [GO:0042149]; lipid droplet disassembly [GO:1905691]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:34077757}.; SUBCELLULAR LOCATION: [Isoform 1]: Lipid droplet {ECO:0000269|PubMed:34077757}. Note=Isoform 1 localizes to lipid droplets following phosphorylation by AMPK. {ECO:0000269|PubMed:34077757}.
P35813	reviewed	PPM1A_HUMAN	Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA)	PPM1A PPPM1A	Homo sapiens (Human)	382	FUNCTION: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}.		cellular response to transforming growth factor beta stimulus [GO:0071560]; dephosphorylation [GO:0016311]; N-terminal protein myristoylation [GO:0006499]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein export from nucleus [GO:0046827]; protein dephosphorylation [GO:0006470]; protein export from nucleus [GO:0006611]; regulation of cell cycle [GO:0051726]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	calmodulin-dependent protein phosphatase activity [GO:0033192]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; R-SMAD binding [GO:0070412]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calmodulin-dependent protein phosphatase activity [GO:0033192]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; R-SMAD binding [GO:0070412]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dephosphorylation [GO:0016311]; N-terminal protein myristoylation [GO:0006499]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein export from nucleus [GO:0046827]; protein dephosphorylation [GO:0006470]; protein export from nucleus [GO:0006611]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16751101}. Cytoplasm, cytosol {ECO:0000269|PubMed:22781750}. Membrane {ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805}; Lipid-anchor {ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250|UniProtKB:P49443}.
P35858	reviewed	ALS_HUMAN	Insulin-like growth factor-binding protein complex acid labile subunit (ALS)	IGFALS ALS	Homo sapiens (Human)	605	FUNCTION: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.		cell adhesion [GO:0007155]; signal transduction [GO:0007165]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor ternary complex [GO:0042567]	insulin-like growth factor binding [GO:0005520]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor ternary complex [GO:0042567]; insulin-like growth factor binding [GO:0005520]; cell adhesion [GO:0007155]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P35869	reviewed	AHR_HUMAN	Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76)	AHR BHLHE76	Homo sapiens (Human)	848	FUNCTION: Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:30373764, PubMed:23275542, PubMed:7961644, PubMed:32818467). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:30373764, PubMed:23275542, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644, PubMed:34521881). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32866000, PubMed:32818467). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}.		apoptotic process [GO:0006915]; blood vessel development [GO:0001568]; cAMP-mediated signaling [GO:0019933]; cell cycle [GO:0007049]; cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cellular response to molecule of bacterial origin [GO:0071219]; circadian regulation of gene expression [GO:0032922]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of adaptive immune response [GO:0002819]; regulation of B cell proliferation [GO:0030888]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; xenobiotic metabolic process [GO:0006805]	aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic aryl hydrocarbon receptor complex [GO:0034752]; nuclear aryl hydrocarbon receptor complex [GO:0034753]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; Hsp90 protein binding [GO:0051879]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]	aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic aryl hydrocarbon receptor complex [GO:0034752]; nuclear aryl hydrocarbon receptor complex [GO:0034753]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; Hsp90 protein binding [GO:0051879]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; apoptotic process [GO:0006915]; blood vessel development [GO:0001568]; cAMP-mediated signaling [GO:0019933]; cell cycle [GO:0007049]; cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cellular response to molecule of bacterial origin [GO:0071219]; circadian regulation of gene expression [GO:0032922]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of adaptive immune response [GO:0002819]; regulation of B cell proliferation [GO:0030888]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34521881}. Nucleus {ECO:0000269|PubMed:34521881}. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. {ECO:0000269|PubMed:34521881}.
P35900	reviewed	K1C20_HUMAN	Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT)	KRT20	Homo sapiens (Human)	424	FUNCTION: Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). {ECO:0000250, ECO:0000269|PubMed:12857878, ECO:0000269|PubMed:16608857}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	apoptotic process [GO:0006915]; cellular response to starvation [GO:0009267]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; regulation of protein secretion [GO:0050708]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]	structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; structural constituent of cytoskeleton [GO:0005200]; apoptotic process [GO:0006915]; cellular response to starvation [GO:0009267]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; regulation of protein secretion [GO:0050708]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10973561, ECO:0000269|PubMed:1696264}.
P35908	reviewed	K22E_HUMAN	Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)	KRT2 KRT2A KRT2E	Homo sapiens (Human)	639	FUNCTION: Probably contributes to terminal cornification (PubMed:1380918). Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329). Required for maintenance of corneocytes and keratin filaments in suprabasal keratinocytes in the epidermis of the ear, potentially via moderation of expression and localization of keratins and their partner proteins (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). {ECO:0000250|UniProtKB:Q3TTY5, ECO:0000269|PubMed:12598329, ECO:0000269|PubMed:1380918}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; keratinocyte activation [GO:0032980]; keratinocyte development [GO:0003334]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; peptide cross-linking [GO:0018149]; positive regulation of epidermis development [GO:0045684]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634]	cytoskeletal protein binding [GO:0008092]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634]; cytoskeletal protein binding [GO:0008092]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280]; epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; keratinocyte activation [GO:0032980]; keratinocyte development [GO:0003334]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; peptide cross-linking [GO:0018149]; positive regulation of epidermis development [GO:0045684]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32179842}.
P35913	reviewed	PDE6B_HUMAN	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35)	PDE6B PDEB	Homo sapiens (Human)	854	FUNCTION: Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP (PubMed:20940301). Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal (PubMed:8394174). {ECO:0000250|UniProtKB:P23440, ECO:0000269|PubMed:20940301, ECO:0000269|PubMed:8394174}.		entrainment of circadian clock by photoperiod [GO:0043153]; phototransduction, visible light [GO:0007603]; retina development in camera-type eye [GO:0060041]; retinal cell apoptotic process [GO:1990009]; signal transduction [GO:0007165]; visual perception [GO:0007601]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]	3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]; entrainment of circadian clock by photoperiod [GO:0043153]; phototransduction, visible light [GO:0007603]; retina development in camera-type eye [GO:0060041]; retinal cell apoptotic process [GO:1990009]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:20940301}.
P35914	reviewed	HMGCL_HUMAN	Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)	HMGCL	Homo sapiens (Human)	325	FUNCTION: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. {ECO:0000269|PubMed:22847177, ECO:0000269|PubMed:22865860, ECO:0000269|PubMed:8566388}.	MISCELLANEOUS: [Isoform 2]: The transcript is not translated, but would result in a catalytically impaired product if it was. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Very low expression. The transcript is not translated, but would result in a catalytically inactive product if it was. {ECO:0000305}.	ketone body biosynthetic process [GO:0046951]; leucine catabolic process [GO:0006552]; lipid metabolic process [GO:0006629]; mitochondrion organization [GO:0007005]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	hydroxymethylglutaryl-CoA lyase activity [GO:0004419]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; structural molecule activity [GO:0005198]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; hydroxymethylglutaryl-CoA lyase activity [GO:0004419]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; structural molecule activity [GO:0005198]; ketone body biosynthetic process [GO:0046951]; leucine catabolic process [GO:0006552]; lipid metabolic process [GO:0006629]; mitochondrion organization [GO:0007005]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P38060}. Peroxisome {ECO:0000250|UniProtKB:P38060}. Note=Unprocessed form is peroxisomal. {ECO:0000250|UniProtKB:P38060}.
P35916	reviewed	VGFR3_HUMAN	Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)	FLT4 VEGFR3	Homo sapiens (Human)	1363	FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}.		angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; lung alveolus development [GO:0048286]; lymph vessel development [GO:0001945]; lymphangiogenesis [GO:0001946]; negative regulation of apoptotic process [GO:0043066]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein autophosphorylation [GO:0046777]; regulation of blood vessel remodeling [GO:0060312]; regulation of MAPK cascade [GO:0043408]; respiratory system process [GO:0003016]; sprouting angiogenesis [GO:0002040]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]; vasculature development [GO:0001944]	cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; growth factor binding [GO:0019838]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; vascular endothelial growth factor receptor activity [GO:0005021]	cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; vascular endothelial growth factor receptor activity [GO:0005021]; angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; lung alveolus development [GO:0048286]; lymph vessel development [GO:0001945]; lymphangiogenesis [GO:0001946]; negative regulation of apoptotic process [GO:0043066]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein autophosphorylation [GO:0046777]; regulation of blood vessel remodeling [GO:0060312]; regulation of MAPK cascade [GO:0043408]; respiratory system process [GO:0003016]; sprouting angiogenesis [GO:0002040]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]; vasculature development [GO:0001944]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:7898938}; Single-pass type I membrane protein. Cytoplasm {ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:20445537}. Nucleus {ECO:0000269|PubMed:16452200}. Note=Ligand-mediated autophosphorylation leads to rapid internalization. {ECO:0000269|PubMed:20445537}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=Ligand-mediated autophosphorylation leads to rapid internalization.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted. Cytoplasm.
P35968	reviewed	VGFR2_HUMAN	Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)	KDR FLK1 VEGFR2	Homo sapiens (Human)	1356	FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. {ECO:0000269|PubMed:10102632, ECO:0000269|PubMed:10368301, ECO:0000269|PubMed:10600473, ECO:0000269|PubMed:11387210, ECO:0000269|PubMed:12649282, ECO:0000269|PubMed:1417831, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15215251, ECO:0000269|PubMed:15962004, ECO:0000269|PubMed:16966330, ECO:0000269|PubMed:17303569, ECO:0000269|PubMed:18529047, ECO:0000269|PubMed:19668192, ECO:0000269|PubMed:19834490, ECO:0000269|PubMed:20080685, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20705758, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:7929439, ECO:0000269|PubMed:9160888, ECO:0000269|PubMed:9804796, ECO:0000269|PubMed:9837777}.		angiogenesis [GO:0001525]; blood vessel endothelial cell differentiation [GO:0060837]; branching involved in blood vessel morphogenesis [GO:0001569]; calcium ion homeostasis [GO:0055074]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell fate commitment [GO:0045165]; cell migration [GO:0016477]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to hydrogen sulfide [GO:1904881]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; embryonic hemopoiesis [GO:0035162]; endocardium development [GO:0003157]; endothelial cell differentiation [GO:0045446]; endothelium development [GO:0003158]; epithelial cell maturation [GO:0002070]; epithelial cell proliferation [GO:0050673]; ERK1 and ERK2 cascade [GO:0070371]; lung alveolus development [GO:0048286]; lymph vessel development [GO:0001945]; mesenchymal cell proliferation [GO:0010463]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; ovarian follicle development [GO:0001541]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of macroautophagy [GO:0016239]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vasculogenesis [GO:2001214]; post-embryonic camera-type eye morphogenesis [GO:0048597]; protein autophosphorylation [GO:0046777]; regulation of bone development [GO:1903010]; regulation of cell shape [GO:0008360]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of MAPK cascade [GO:0043408]; semaphorin-plexin signaling pathway [GO:0071526]; stem cell proliferation [GO:0072089]; surfactant homeostasis [GO:0043129]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; vascular endothelial growth factor signaling pathway [GO:0038084]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; sorting endosome [GO:0097443]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; coreceptor activity [GO:0015026]; growth factor binding [GO:0019838]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; sorting endosome [GO:0097443]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; coreceptor activity [GO:0015026]; growth factor binding [GO:0019838]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021]; angiogenesis [GO:0001525]; blood vessel endothelial cell differentiation [GO:0060837]; branching involved in blood vessel morphogenesis [GO:0001569]; calcium ion homeostasis [GO:0055074]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell fate commitment [GO:0045165]; cell migration [GO:0016477]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to hydrogen sulfide [GO:1904881]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; embryonic hemopoiesis [GO:0035162]; endocardium development [GO:0003157]; endothelial cell differentiation [GO:0045446]; endothelium development [GO:0003158]; epithelial cell maturation [GO:0002070]; epithelial cell proliferation [GO:0050673]; ERK1 and ERK2 cascade [GO:0070371]; lung alveolus development [GO:0048286]; lymph vessel development [GO:0001945]; mesenchymal cell proliferation [GO:0010463]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; ovarian follicle development [GO:0001541]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of macroautophagy [GO:0016239]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vasculogenesis [GO:2001214]; post-embryonic camera-type eye morphogenesis [GO:0048597]; protein autophosphorylation [GO:0046777]; regulation of bone development [GO:1903010]; regulation of cell shape [GO:0008360]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of MAPK cascade [GO:0043408]; semaphorin-plexin signaling pathway [GO:0071526]; stem cell proliferation [GO:0072089]; surfactant homeostasis [GO:0043129]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; vascular endothelial growth factor signaling pathway [GO:0038084]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cell junction {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:23529610}. Cell membrane {ECO:0000269|PubMed:25825981}. Note=Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). {ECO:0000250, ECO:0000269|PubMed:23529610}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
P35998	reviewed	PRS7_HUMAN	26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2)	PSMC2 MSS1	Homo sapiens (Human)	433	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:28539385, ECO:0000269|PubMed:9295362}.		osteoblast differentiation [GO:0001649]; positive regulation of proteasomal protein catabolic process [GO:1901800]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; secretory granule lumen [GO:0034774]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; secretory granule lumen [GO:0034774]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]; osteoblast differentiation [GO:0001649]; positive regulation of proteasomal protein catabolic process [GO:1901800]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22078707}. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000269|PubMed:22078707}.
P36021	reviewed	MOT8_HUMAN	Monocarboxylate transporter 8 (MCT 8) (Monocarboxylate transporter 7) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter)	SLC16A2 MCT7 MCT8 XPCT	Homo sapiens (Human)	539	FUNCTION: Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) (PubMed:23550058, PubMed:26426690, PubMed:16887882, PubMed:27805744, PubMed:20628049, PubMed:18337592, PubMed:31436139). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable) (PubMed:28526555). {ECO:0000269|PubMed:16887882, ECO:0000269|PubMed:18337592, ECO:0000269|PubMed:20628049, ECO:0000269|PubMed:23550058, ECO:0000269|PubMed:26426690, ECO:0000269|PubMed:27805744, ECO:0000269|PubMed:28526555, ECO:0000269|PubMed:31436139, ECO:0000305|PubMed:18636565}.	MISCELLANEOUS: Abnormal brain development associated with MCT8 deficiency may be the consequence of either decreased or increased intracellular T3 concentrations. {ECO:0000269|PubMed:18636565}.	amino acid import across plasma membrane [GO:0089718]; amino acid metabolic process [GO:0006520]; monocarboxylic acid transport [GO:0015718]; negative regulation of neural precursor cell proliferation [GO:2000178]; thyroid hormone generation [GO:0006590]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327]; thyroid-stimulating hormone secretion [GO:0070460]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; identical protein binding [GO:0042802]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; thyroid hormone transmembrane transporter activity [GO:0015349]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; identical protein binding [GO:0042802]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; thyroid hormone transmembrane transporter activity [GO:0015349]; amino acid import across plasma membrane [GO:0089718]; amino acid metabolic process [GO:0006520]; monocarboxylic acid transport [GO:0015718]; negative regulation of neural precursor cell proliferation [GO:2000178]; thyroid hormone generation [GO:0006590]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327]; thyroid-stimulating hormone secretion [GO:0070460]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20628049, ECO:0000269|PubMed:23550058, ECO:0000269|PubMed:25527620, ECO:0000269|PubMed:26426690}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000255}.
P36222	reviewed	CH3L1_HUMAN	Chitinase-3-like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40)	CHI3L1	Homo sapiens (Human)	383	FUNCTION: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:9492324}.		activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to tumor necrosis factor [GO:0071356]; chitin catabolic process [GO:0006032]; inflammatory response [GO:0006954]; lung development [GO:0030324]; positive regulation of angiogenesis [GO:0045766]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; response to interleukin-1 [GO:0070555]; response to interleukin-6 [GO:0070741]; response to mechanical stimulus [GO:0009612]; response to tumor necrosis factor [GO:0034612]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; specific granule lumen [GO:0035580]	carbohydrate binding [GO:0030246]; chitin binding [GO:0008061]; extracellular matrix structural constituent [GO:0005201]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; specific granule lumen [GO:0035580]; carbohydrate binding [GO:0030246]; chitin binding [GO:0008061]; extracellular matrix structural constituent [GO:0005201]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to tumor necrosis factor [GO:0071356]; chitin catabolic process [GO:0006032]; inflammatory response [GO:0006954]; lung development [GO:0030324]; positive regulation of angiogenesis [GO:0045766]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; response to interleukin-1 [GO:0070555]; response to interleukin-6 [GO:0070741]; response to mechanical stimulus [GO:0009612]; response to tumor necrosis factor [GO:0034612]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:9492324}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
P36268	reviewed	GGT2_HUMAN	Inactive glutathione hydrolase 2 (Gamma-glutamyltransferase 2 pseudogene) (Inactive gamma-glutamyltranspeptidase 2) (GGT 2)	GGT2P GGT2	Homo sapiens (Human)	569	FUNCTION: [Isoform 1]: Lacks catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer. {ECO:0000269|PubMed:23682772}.; FUNCTION: [Isoform 2]: Lacks catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer. {ECO:0000269|PubMed:23682772}.; FUNCTION: [Isoform 3]: Lacks catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer. {ECO:0000269|PubMed:23682772}.		glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]; peptide modification [GO:0031179]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]		endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]; peptide modification [GO:0031179]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:23682772}. Endoplasmic reticulum {ECO:0000269|PubMed:23682772}. Note=Co-localizes with calnexin in the endoplasmic reticulum.
P36269	reviewed	GGT5_HUMAN	Glutathione hydrolase 5 proenzyme (EC 3.4.19.13) (Gamma-glutamyl transpeptidase-related enzyme) (GGT-rel) (Gamma-glutamyltransferase 5) (GGT 5) (EC 2.3.2.2) (Gamma-glutamyltransferase-like activity 1) (Gamma-glutamyltranspeptidase 5) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) [Cleaved into: Glutathione hydrolase 5 heavy chain; Glutathione hydrolase 5 light chain]	GGT5 GGTLA1	Homo sapiens (Human)	586	FUNCTION: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 (PubMed:21447318). Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine (PubMed:21447318). May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318). Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656). {ECO:0000269|PubMed:21447318, ECO:0000269|PubMed:30842656}.	MISCELLANEOUS: A previous study reported that GSH and oxidized glutathione (GSSG) are not substrates for murine GGT5 (By similarity). However, this result contrasts with two studies reported that GSH is indeed a substrate for GGT5 (PubMed:21447318, PubMed:1676842). {ECO:0000250|UniProtKB:Q9Z2A9, ECO:0000269|PubMed:1676842, ECO:0000269|PubMed:21447318}.	amino acid metabolic process [GO:0006520]; fatty acid metabolic process [GO:0006631]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; inflammatory response [GO:0006954]; leukotriene D4 biosynthetic process [GO:1901750]; proteolysis [GO:0006508]	plasma membrane [GO:0005886]	glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; leukotriene-C(4) hydrolase [GO:0002951]; peptidyltransferase activity [GO:0000048]	plasma membrane [GO:0005886]; glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; leukotriene-C(4) hydrolase [GO:0002951]; peptidyltransferase activity [GO:0000048]; amino acid metabolic process [GO:0006520]; fatty acid metabolic process [GO:0006631]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; inflammatory response [GO:0006954]; leukotriene D4 biosynthetic process [GO:1901750]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9Z2A9}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9Z2A9}.
P36382	reviewed	CXA5_HUMAN	Gap junction alpha-5 protein (Connexin-40) (Cx40)	GJA5	Homo sapiens (Human)	358	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.		angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; atrial cardiac muscle cell to AV node cell communication by electrical coupling [GO:0086044]; atrial septum development [GO:0003283]; AV node cell to bundle of His cell communication by electrical coupling [GO:0086053]; bundle of His cell to Purkinje myocyte communication by electrical coupling [GO:0086054]; cardiac conduction system development [GO:0003161]; cell communication by chemical coupling [GO:0010643]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-cell signaling [GO:0007267]; endothelium development [GO:0003158]; gap junction assembly [GO:0016264]; heart development [GO:0007507]; mitral valve development [GO:0003174]; negative regulation of blood pressure [GO:0045776]; negative regulation of glomerular filtration [GO:0003105]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell communication by chemical coupling [GO:0010652]; positive regulation of vasoconstriction [GO:0045907]; potassium ion transport [GO:0006813]; pulmonary valve formation [GO:0003193]; Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling [GO:0086055]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of AV node cell action potential [GO:0098904]; regulation of bundle of His cell action potential [GO:0098905]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of Purkinje myocyte action potential [GO:0098906]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; SA node cell to atrial cardiac muscle cell communication by electrical coupling [GO:0086021]; vasodilation [GO:0042311]; vasomotion [GO:1990029]; ventricular septum development [GO:0003281]	cell projection [GO:0042995]; connexin complex [GO:0005922]; gap junction [GO:0005921]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886]	connexin binding [GO:0071253]; disordered domain specific binding [GO:0097718]; gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling [GO:0086076]; gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling [GO:0086077]; gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling [GO:0086078]; gap junction channel activity involved in cardiac conduction electrical coupling [GO:0086075]; gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling [GO:0086079]; gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling [GO:0086020]; gap junction hemi-channel activity [GO:0055077]	cell projection [GO:0042995]; connexin complex [GO:0005922]; gap junction [GO:0005921]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; connexin binding [GO:0071253]; disordered domain specific binding [GO:0097718]; gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling [GO:0086076]; gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling [GO:0086077]; gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling [GO:0086078]; gap junction channel activity involved in cardiac conduction electrical coupling [GO:0086075]; gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling [GO:0086079]; gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling [GO:0086020]; gap junction hemi-channel activity [GO:0055077]; angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; atrial cardiac muscle cell to AV node cell communication by electrical coupling [GO:0086044]; atrial septum development [GO:0003283]; AV node cell to bundle of His cell communication by electrical coupling [GO:0086053]; bundle of His cell to Purkinje myocyte communication by electrical coupling [GO:0086054]; cardiac conduction system development [GO:0003161]; cell communication by chemical coupling [GO:0010643]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-cell signaling [GO:0007267]; endothelium development [GO:0003158]; gap junction assembly [GO:0016264]; heart development [GO:0007507]; mitral valve development [GO:0003174]; negative regulation of blood pressure [GO:0045776]; negative regulation of glomerular filtration [GO:0003105]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell communication by chemical coupling [GO:0010652]; positive regulation of vasoconstriction [GO:0045907]; potassium ion transport [GO:0006813]; pulmonary valve formation [GO:0003193]; Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling [GO:0086055]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of AV node cell action potential [GO:0098904]; regulation of bundle of His cell action potential [GO:0098905]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of Purkinje myocyte action potential [GO:0098906]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; SA node cell to atrial cardiac muscle cell communication by electrical coupling [GO:0086021]; vasodilation [GO:0042311]; vasomotion [GO:1990029]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
P36383	reviewed	CXG1_HUMAN	Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein)	GJC1 GJA7	Homo sapiens (Human)	396	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.		atrial cardiac muscle cell action potential [GO:0086014]; AV node cell to bundle of His cell communication by electrical coupling [GO:0086053]; cardiac muscle tissue development [GO:0048738]; cell development [GO:0048468]; cell-cell junction assembly [GO:0007043]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; gap junction assembly [GO:0016264]; muscle contraction [GO:0006936]; SA node cell to atrial cardiac muscle cell communication by electrical coupling [GO:0086021]; vasculogenesis [GO:0001570]; visual perception [GO:0007601]	connexin complex [GO:0005922]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gap junction [GO:0005921]; intercalated disc [GO:0014704]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202]	gap junction channel activity [GO:0005243]; gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling [GO:0086077]; gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling [GO:0086020]; monoatomic ion channel activity [GO:0005216]	connexin complex [GO:0005922]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gap junction [GO:0005921]; intercalated disc [GO:0014704]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202]; gap junction channel activity [GO:0005243]; gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling [GO:0086077]; gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling [GO:0086020]; monoatomic ion channel activity [GO:0005216]; atrial cardiac muscle cell action potential [GO:0086014]; AV node cell to bundle of His cell communication by electrical coupling [GO:0086053]; cardiac muscle tissue development [GO:0048738]; cell development [GO:0048468]; cell-cell junction assembly [GO:0007043]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; gap junction assembly [GO:0016264]; muscle contraction [GO:0006936]; SA node cell to atrial cardiac muscle cell communication by electrical coupling [GO:0086021]; vasculogenesis [GO:0001570]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
P36402	reviewed	TCF7_HUMAN	Transcription factor 7 (TCF-7) (T-cell-specific transcription factor 1) (T-cell factor 1) (TCF-1)	TCF7 TCF1	Homo sapiens (Human)	384	FUNCTION: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. {ECO:0000250|UniProtKB:Q00417}.	MISCELLANEOUS: [Isoform 1L]: Produced by alternative splicing of isoform 4L. {ECO:0000305}.; MISCELLANEOUS: [Isoform 1S]: Produced by alternative splicing of isoform 4S. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5L]: Produced by alternative splicing of isoform 4L. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5S]: Produced by alternative splicing of isoform 4S. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6L]: Produced by alternative splicing of isoform 4L. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6S]: Produced by alternative splicing of isoform 4S. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7L]: Produced by alternative splicing of isoform 4L. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7S]: Produced by alternative splicing of isoform 4S. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8L]: Produced by alternative splicing of isoform 4L. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8S]: Produced by alternative splicing of isoform 4S. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2L]: Produced by alternative splicing of isoform 4L. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2S]: Produced by alternative splicing of isoform 4S. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3L]: Produced by alternative splicing of isoform 4L. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3S]: Produced by alternative splicing of isoform 4S. {ECO:0000305}.	canonical Wnt signaling pathway [GO:0060070]; cellular response to interleukin-4 [GO:0071353]; gamma-delta T cell differentiation [GO:0042492]; immune response [GO:0006955]; regulation of DNA-templated transcription [GO:0006355]; regulation of gamma-delta T cell differentiation [GO:0045586]; regulation of transcription by RNA polymerase II [GO:0006357]	beta-catenin-TCF complex [GO:1990907]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	beta-catenin-TCF complex [GO:1990907]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; canonical Wnt signaling pathway [GO:0060070]; cellular response to interleukin-4 [GO:0071353]; gamma-delta T cell differentiation [GO:0042492]; immune response [GO:0006955]; regulation of DNA-templated transcription [GO:0006355]; regulation of gamma-delta T cell differentiation [GO:0045586]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P36404	reviewed	ARL2_HUMAN	ADP-ribosylation factor-like protein 2	ARL2	Homo sapiens (Human)	184	FUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle (PubMed:10831612, PubMed:16525022, PubMed:18234692, PubMed:18588884, PubMed:20740604). Also regulates mitochondrial integrity and function (PubMed:30945270). {ECO:0000269|PubMed:10831612, ECO:0000269|PubMed:16525022, ECO:0000269|PubMed:18234692, ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:20740604, ECO:0000269|PubMed:30945270}.		bicellular tight junction assembly [GO:0070830]; centrosome cycle [GO:0007098]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of GTPase activity [GO:0034260]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of microtubule polymerization [GO:0031116]; protein folding [GO:0006457]; regulation of aerobic respiration [GO:1903715]; regulation of glycolytic process [GO:0006110]; regulation of microtubule polymerization [GO:0031113]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lateral plasma membrane [GO:0016328]; microtubule cytoskeleton [GO:0015630]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lateral plasma membrane [GO:0016328]; microtubule cytoskeleton [GO:0015630]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; bicellular tight junction assembly [GO:0070830]; centrosome cycle [GO:0007098]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of GTPase activity [GO:0034260]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of microtubule polymerization [GO:0031116]; protein folding [GO:0006457]; regulation of aerobic respiration [GO:1903715]; regulation of glycolytic process [GO:0006110]; regulation of microtubule polymerization [GO:0031113]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000305|PubMed:30945270}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. {ECO:0000250|UniProtKB:O08697}.
P36405	reviewed	ARL3_HUMAN	ADP-ribosylation factor-like protein 3	ARL3 ARFL3	Homo sapiens (Human)	182	FUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:16525022, PubMed:18588884). Required for normal cytokinesis and cilia signaling (PubMed:22085962). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E (PubMed:30269812). Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (PubMed:22085962). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity). {ECO:0000250|UniProtKB:Q9WUL7, ECO:0000269|PubMed:16525022, ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:22085962}.		cilium assembly [GO:0060271]; Golgi to plasma membrane transport [GO:0006893]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; mitotic cytokinesis [GO:0000281]; photoreceptor cell development [GO:0042461]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to ciliary membrane [GO:1903441]; protein localization to cilium [GO:0061512]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; smoothened signaling pathway [GO:0007224]	centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; spindle microtubule [GO:0005876]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]	centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; spindle microtubule [GO:0005876]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; cilium assembly [GO:0060271]; Golgi to plasma membrane transport [GO:0006893]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; mitotic cytokinesis [GO:0000281]; photoreceptor cell development [GO:0042461]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to ciliary membrane [GO:1903441]; protein localization to cilium [GO:0061512]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium {ECO:0000269|PubMed:30269812}. Note=Detected predominantly in the photoreceptor connecting cilium. Present on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules.
P36406	reviewed	TRI23_HUMAN	E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)	TRIM23 ARD1 ARFD1 RNF46	Homo sapiens (Human)	574	FUNCTION: Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090). {ECO:0000269|PubMed:15684077, ECO:0000269|PubMed:28871090}.; FUNCTION: (Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection. {ECO:0000269|PubMed:15684077}.		innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; positive regulation of autophagy [GO:0010508]; protein ubiquitination [GO:0016567]; vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	enzyme activator activity [GO:0008047]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; enzyme activator activity [GO:0008047]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; positive regulation of autophagy [GO:0010508]; protein ubiquitination [GO:0016567]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28871090}. Endomembrane system {ECO:0000269|PubMed:9671726}. Golgi apparatus membrane {ECO:0000269|PubMed:9671726}. Lysosome membrane {ECO:0000269|PubMed:9671726}. Note=Membrane-associated with the Golgi complex and lysosomal structures.
P36507	reviewed	MP2K2_HUMAN	Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)	MAP2K2 MEK2 MKK2 PRKMK2	Homo sapiens (Human)	400	FUNCTION: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}.		epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; MAPK cascade [GO:0000165]; peptidyl-serine autophosphorylation [GO:0036289]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell motility [GO:2000147]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of axon regeneration [GO:0048679]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]	cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]	ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]	cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; MAPK cascade [GO:0000165]; peptidyl-serine autophosphorylation [GO:0036289]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell motility [GO:2000147]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of axon regeneration [GO:0048679]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10409742}. Membrane {ECO:0000269|PubMed:10409742}; Peripheral membrane protein {ECO:0000269|PubMed:10409742}. Note=Membrane localization is probably regulated by its interaction with KSR1. {ECO:0000269|PubMed:10409742}.
P36508	reviewed	ZNF76_HUMAN	Zinc finger protein 76 (Zinc finger protein 523)	ZNF76 D6S229E ZNF523	Homo sapiens (Human)	570	FUNCTION: May be involved in transcriptional regulation.		central nervous system development [GO:0007417]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription by RNA polymerase III [GO:0006359]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; central nervous system development [GO:0007417]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription by RNA polymerase III [GO:0006359]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P36542	reviewed	ATPG_HUMAN	ATP synthase subunit gamma, mitochondrial (ATP synthase F1 subunit gamma) (F-ATPase gamma subunit)	ATP5F1C ATP5C ATP5C1 ATP5CL1	Homo sapiens (Human)	298	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. {ECO:0000250|UniProtKB:P05631}.		ATP biosynthetic process [GO:0006754]; oxidative phosphorylation [GO:0006119]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) [GO:0000275]; mitochondrion [GO:0005739]	proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; RNA binding [GO:0003723]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) [GO:0000275]; mitochondrion [GO:0005739]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; RNA binding [GO:0003723]; ATP biosynthetic process [GO:0006754]; oxidative phosphorylation [GO:0006119]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P05631}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05631}; Matrix side {ECO:0000250|UniProtKB:P05631}.
P36543	reviewed	VATE1_HUMAN	V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa subunit) (p31) (Vacuolar proton pump subunit E 1)	ATP6V1E1 ATP6E ATP6E2	Homo sapiens (Human)	226	FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002, PubMed:32001091). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). {ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}.		proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]	apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; microvillus [GO:0005902]; proton-transporting two-sector ATPase complex [GO:0016469]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; microvillus [GO:0005902]; proton-transporting two-sector ATPase complex [GO:0016469]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:29993276}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q6PCU2}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q6PCU2}; Peripheral membrane protein {ECO:0000305}.
P36544	reviewed	ACHA7_HUMAN	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7 NACHRA7	Homo sapiens (Human)	502	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	acetylcholine receptor signaling pathway [GO:0095500]; associative learning [GO:0008306]; B cell activation [GO:0042113]; behavioral response to ethanol [GO:0048149]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; cognition [GO:0050890]; dendrite arborization [GO:0140059]; dendritic spine organization [GO:0097061]; endocytosis [GO:0006897]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; generation of ovulation cycle rhythm [GO:0060112]; intracellular calcium ion homeostasis [GO:0006874]; learning or memory [GO:0007611]; memory [GO:0007613]; modulation of excitatory postsynaptic potential [GO:0098815]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure [GO:0001988]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; regulation of amyloid fibril formation [GO:1905906]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of norepinephrine secretion [GO:0014061]; regulation of synapse structural plasticity [GO:0051823]; regulation of synaptic transmission, dopaminergic [GO:0032225]; response to acetylcholine [GO:1905144]; response to amyloid-beta [GO:1904645]; response to cold [GO:0009409]; response to food [GO:0032094]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; sensory processing [GO:0050893]; short-term memory [GO:0007614]; signal transduction [GO:0007165]; synapse organization [GO:0050808]; synaptic transmission, cholinergic [GO:0007271]; T cell activation [GO:0042110]	acetylcholine-gated channel complex [GO:0005892]; apical plasma membrane [GO:0016324]; axolemma [GO:0030673]; cholinergic synapse [GO:0098981]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; calcium channel activity [GO:0005262]; chloride channel regulator activity [GO:0017081]; monoatomic ion channel activity [GO:0005216]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; apical plasma membrane [GO:0016324]; axolemma [GO:0030673]; cholinergic synapse [GO:0098981]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; calcium channel activity [GO:0005262]; chloride channel regulator activity [GO:0017081]; monoatomic ion channel activity [GO:0005216]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]; acetylcholine receptor signaling pathway [GO:0095500]; associative learning [GO:0008306]; B cell activation [GO:0042113]; behavioral response to ethanol [GO:0048149]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; cognition [GO:0050890]; dendrite arborization [GO:0140059]; dendritic spine organization [GO:0097061]; endocytosis [GO:0006897]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; generation of ovulation cycle rhythm [GO:0060112]; intracellular calcium ion homeostasis [GO:0006874]; learning or memory [GO:0007611]; memory [GO:0007613]; modulation of excitatory postsynaptic potential [GO:0098815]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure [GO:0001988]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; regulation of amyloid fibril formation [GO:1905906]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of norepinephrine secretion [GO:0014061]; regulation of synapse structural plasticity [GO:0051823]; regulation of synaptic transmission, dopaminergic [GO:0032225]; response to acetylcholine [GO:1905144]; response to amyloid-beta [GO:1904645]; response to cold [GO:0009409]; response to food [GO:0032094]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; sensory processing [GO:0050893]; short-term memory [GO:0007614]; signal transduction [GO:0007165]; synapse organization [GO:0050808]; synaptic transmission, cholinergic [GO:0007271]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:27789755}; Multi-pass membrane protein {ECO:0000255}. Note=TMEM35A/NACHO promotes its trafficking to the cell membrane (PubMed:27789755). RIC3 promotes its trafficking to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q05941, ECO:0000269|PubMed:27789755}.
P36551	reviewed	HEM6_HUMAN	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3)	CPOX CPO CPX	Homo sapiens (Human)	454	FUNCTION: Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX and participates to the sixth step in the heme biosynthetic pathway. {ECO:0000269|PubMed:8159699}.		heme biosynthetic process [GO:0006783]; protoporphyrinogen IX biosynthetic process [GO:0006782]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]	coproporphyrinogen oxidase activity [GO:0004109]; protein homodimerization activity [GO:0042803]; structural constituent of eye lens [GO:0005212]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; coproporphyrinogen oxidase activity [GO:0004109]; protein homodimerization activity [GO:0042803]; structural constituent of eye lens [GO:0005212]; heme biosynthetic process [GO:0006783]; protoporphyrinogen IX biosynthetic process [GO:0006782]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space.
P36575	reviewed	ARRC_HUMAN	Arrestin-C (Cone arrestin) (C-arrestin) (cArr) (Retinal cone arrestin-3) (X-arrestin)	ARR3 ARRX CAR	Homo sapiens (Human)	388	FUNCTION: May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.		G protein-coupled receptor internalization [GO:0002031]; regulation of protein phosphorylation [GO:0001932]; signal transduction [GO:0007165]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; synapse [GO:0045202]	G protein-coupled receptor binding [GO:0001664]; opsin binding [GO:0002046]; phosphoprotein binding [GO:0051219]	cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; synapse [GO:0045202]; G protein-coupled receptor binding [GO:0001664]; opsin binding [GO:0002046]; phosphoprotein binding [GO:0051219]; G protein-coupled receptor internalization [GO:0002031]; regulation of protein phosphorylation [GO:0001932]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9EQP6}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9EQP6}.
P36578	reviewed	RL4_HUMAN	Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4)	RPL4 RPL1	Homo sapiens (Human)	427	FUNCTION: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; rough endoplasmic reticulum [GO:0005791]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; rough endoplasmic reticulum [GO:0005791]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P36639	reviewed	8ODP_HUMAN	Oxidized purine nucleoside triphosphate hydrolase (EC 3.6.1.56) (2-hydroxy-dATP diphosphatase) (7,8-dihydro-8-oxoguanine triphosphatase) (8-oxo-dGTPase) (Methylated purine nucleoside triphosphate hydrolase) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 1) (Nudix motif 1)	NUDT1 MTH1	Homo sapiens (Human)	156	FUNCTION: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:22556419, PubMed:26238318, PubMed:24695224, PubMed:24695225, PubMed:28679043). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:10373420). Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:10373420, PubMed:11139615). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:24695224, PubMed:24695225, PubMed:30304478, PubMed:32144205). {ECO:0000269|PubMed:10373420, ECO:0000269|PubMed:10608900, ECO:0000269|PubMed:11139615, ECO:0000269|PubMed:11756418, ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:16607562, ECO:0000269|PubMed:22556419, ECO:0000269|PubMed:24695224, ECO:0000269|PubMed:24695225, ECO:0000269|PubMed:26238318, ECO:0000269|PubMed:26999531, ECO:0000269|PubMed:28035004, ECO:0000269|PubMed:28679043, ECO:0000269|PubMed:30304478, ECO:0000269|PubMed:32144205, ECO:0000269|PubMed:7713500, ECO:0000269|PubMed:8226881}.	MISCELLANEOUS: [Isoform p26]: Contains a predicted transit peptide (1-18) for localization to the mitochondrion. {ECO:0000255}.; MISCELLANEOUS: [Isoform p26]: Derived from a B-type mRNA with a polymorphic alteration (GU-->GC) at the beginning of exon 2c that converts an in-frame UGA to CGA yielding another in-frame AUG further upstream.	DNA protection [GO:0042262]; DNA repair [GO:0006281]; male gonad development [GO:0008584]; purine nucleoside catabolic process [GO:0006152]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]	2-hydroxy-ATP hydrolase activity [GO:0106377]; 2-hydroxy-dATP hydrolase activity [GO:0106378]; 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity [GO:0035539]; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; ATP diphosphatase activity [GO:0047693]; dATP diphosphatase activity [GO:0008828]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; metal ion binding [GO:0046872]; N6-methyl-(d)ATP hydrolase activity [GO:0106431]; O6-methyl-dGTP hydrolase activity [GO:0106433]; snoRNA binding [GO:0030515]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; 2-hydroxy-ATP hydrolase activity [GO:0106377]; 2-hydroxy-dATP hydrolase activity [GO:0106378]; 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity [GO:0035539]; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; ATP diphosphatase activity [GO:0047693]; dATP diphosphatase activity [GO:0008828]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; metal ion binding [GO:0046872]; N6-methyl-(d)ATP hydrolase activity [GO:0106431]; O6-methyl-dGTP hydrolase activity [GO:0106433]; snoRNA binding [GO:0030515]; DNA protection [GO:0042262]; DNA repair [GO:0006281]; male gonad development [GO:0008584]; purine nucleoside catabolic process [GO:0006152]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: [Isoform p18]: Cytoplasm, cytosol {ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:16607562, ECO:0000269|PubMed:7782328}. Mitochondrion matrix {ECO:0000269|PubMed:7782328, ECO:0000305|PubMed:12857738, ECO:0000305|PubMed:16607562}. Nucleus {ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:7782328}. Note=Mostly present in cytosol (PubMed:7782328). A minor proportion is mitochondrial (PubMed:7782328). A very small amount of the protein is associated with nuclei (PubMed:7782328). {ECO:0000269|PubMed:16607562, ECO:0000269|PubMed:7782328}.; SUBCELLULAR LOCATION: [Isoform p26]: Mitochondrion matrix {ECO:0000269|PubMed:16607562}.
P36776	reviewed	LONM_HUMAN	Lon protease homolog, mitochondrial (EC 3.4.21.53) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15)	LONP1 PRSS15	Homo sapiens (Human)	959	FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix (PubMed:12198491, PubMed:15870080, PubMed:8248235, PubMed:17579211, PubMed:37327776). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m (PubMed:17579211, PubMed:28377575, PubMed:37327776). MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). May also have a chaperone function in the assembly of inner membrane protein complexes (By similarity). Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome (PubMed:17420247). Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner (PubMed:17420247). May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:14739292, PubMed:17420247). {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:14739292, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:17579211, ECO:0000269|PubMed:28377575, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:8248235}.		cellular response to oxidative stress [GO:0034599]; chaperone-mediated protein complex assembly [GO:0051131]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrial genome maintenance [GO:0000002]; mitochondrion organization [GO:0007005]; negative regulation of insulin receptor signaling pathway [GO:0046627]; oxidation-dependent protein catabolic process [GO:0070407]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to aluminum ion [GO:0010044]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; DNA polymerase binding [GO:0070182]; G-quadruplex DNA binding [GO:0051880]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; PH domain binding [GO:0042731]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; DNA polymerase binding [GO:0070182]; G-quadruplex DNA binding [GO:0051880]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; PH domain binding [GO:0042731]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; cellular response to oxidative stress [GO:0034599]; chaperone-mediated protein complex assembly [GO:0051131]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrial genome maintenance [GO:0000002]; mitochondrion organization [GO:0007005]; negative regulation of insulin receptor signaling pathway [GO:0046627]; oxidation-dependent protein catabolic process [GO:0070407]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to aluminum ion [GO:0010044]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:7961901}.
P36871	reviewed	PGM1_HUMAN	Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1)	PGM1	Homo sapiens (Human)	562	FUNCTION: This enzyme participates in both the breakdown and synthesis of glucose. {ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802}.		carbohydrate metabolic process [GO:0005975]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724]	magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724]; magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]; carbohydrate metabolic process [GO:0005975]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm.
P36873	reviewed	PP1G_HUMAN	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)	PPP1CC	Homo sapiens (Human)	323	FUNCTION: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208}.	MISCELLANEOUS: Microcystin toxin is bound to Cys-273 through a thioether bond.	blastocyst development [GO:0001824]; cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; MAPK cascade [GO:0000165]; neuron differentiation [GO:0030182]; positive regulation of glial cell proliferation [GO:0060252]; protein dephosphorylation [GO:0006470]; regulation of circadian rhythm [GO:0042752]; regulation of nucleocytoplasmic transport [GO:0046822]; spermatogenesis [GO:0007283]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; midbody [GO:0030496]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; PTW/PP1 phosphatase complex [GO:0072357]	lamin binding [GO:0005521]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; midbody [GO:0030496]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; PTW/PP1 phosphatase complex [GO:0072357]; lamin binding [GO:0005521]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; blastocyst development [GO:0001824]; cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; MAPK cascade [GO:0000165]; neuron differentiation [GO:0030182]; positive regulation of glial cell proliferation [GO:0060252]; protein dephosphorylation [GO:0006470]; regulation of circadian rhythm [GO:0042752]; regulation of nucleocytoplasmic transport [GO:0046822]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11739654}. Nucleus. Nucleus, nucleolus {ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:20926688, ECO:0000269|PubMed:23789093}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11739654}. Nucleus speckle {ECO:0000269|PubMed:11739654}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12529430}. Cleavage furrow {ECO:0000269|PubMed:12529430}. Midbody {ECO:0000269|PubMed:12529430}. Mitochondrion {ECO:0000269|PubMed:17936702}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:23789093}. Note=Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion (PubMed:17936702). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654). Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019). In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654). Shows a dynamic targeting to specific sites throughout the cell cycle (PubMed:12529430). Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis (PubMed:12529430). Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase (PubMed:12529430). Also accumulates at the cleavage furrow and midbody by telophase (PubMed:12529430). Colocalizes with DYNLT4 in the microtubule organizing center (MTOC)(PubMed:23789093). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:12529430, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:17965019, ECO:0000269|PubMed:23789093}.
P36888	reviewed	FLT3_HUMAN	Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)	FLT3 CD135 FLK2 STK1	Homo sapiens (Human)	993	FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}.	MISCELLANEOUS: Can be used as diagnostic tool to establish the exact cause of acute myeloid leukemia, and to determine the optimal therapy.	animal organ regeneration [GO:0031100]; B cell differentiation [GO:0030183]; cellular response to cytokine stimulus [GO:0071345]; cellular response to glucocorticoid stimulus [GO:0071385]; common myeloid progenitor cell proliferation [GO:0035726]; cytokine-mediated signaling pathway [GO:0019221]; dendritic cell differentiation [GO:0097028]; hemopoiesis [GO:0030097]; leukocyte homeostasis [GO:0001776]; lymphocyte proliferation [GO:0046651]; myeloid progenitor cell differentiation [GO:0002318]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; pro-B cell differentiation [GO:0002328]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; response to organonitrogen compound [GO:0010243]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]; nuclear glucocorticoid receptor binding [GO:0035259]; protein self-association [GO:0043621]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; vascular endothelial growth factor receptor activity [GO:0005021]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]; nuclear glucocorticoid receptor binding [GO:0035259]; protein self-association [GO:0043621]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; vascular endothelial growth factor receptor activity [GO:0005021]; animal organ regeneration [GO:0031100]; B cell differentiation [GO:0030183]; cellular response to cytokine stimulus [GO:0071345]; cellular response to glucocorticoid stimulus [GO:0071385]; common myeloid progenitor cell proliferation [GO:0035726]; cytokine-mediated signaling pathway [GO:0019221]; dendritic cell differentiation [GO:0097028]; hemopoiesis [GO:0030097]; leukocyte homeostasis [GO:0001776]; lymphocyte proliferation [GO:0046651]; myeloid progenitor cell differentiation [GO:0002318]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; pro-B cell differentiation [GO:0002328]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; response to organonitrogen compound [GO:0010243]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.
P36894	reviewed	BMR1A_HUMAN	Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)	BMPR1A ACVRLK3 ALK3	Homo sapiens (Human)	532	FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). {ECO:0000250|UniProtKB:P36895}.		angiogenesis [GO:0001525]; atrioventricular node cell development [GO:0060928]; atrioventricular valve development [GO:0003171]; BMP signaling pathway [GO:0030509]; cardiac conduction system development [GO:0003161]; cardiac right ventricle morphogenesis [GO:0003215]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; central nervous system neuron differentiation [GO:0021953]; chondrocyte differentiation [GO:0002062]; developmental growth [GO:0048589]; dorsal aorta morphogenesis [GO:0035912]; dorsal/ventral axis specification [GO:0009950]; dorsal/ventral pattern formation [GO:0009953]; ectoderm development [GO:0007398]; embryonic digit morphogenesis [GO:0042733]; embryonic organ development [GO:0048568]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; epithelial cell proliferation [GO:0050673]; fibrous ring of heart morphogenesis [GO:1905285]; heart formation [GO:0060914]; hindlimb morphogenesis [GO:0035137]; immune response [GO:0006955]; in utero embryonic development [GO:0001701]; lateral mesoderm development [GO:0048368]; lung development [GO:0030324]; mesendoderm development [GO:0048382]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; Mullerian duct regression [GO:0001880]; negative regulation of gene expression [GO:0010629]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of neurogenesis [GO:0050768]; negative regulation of smooth muscle cell migration [GO:0014912]; neural crest cell development [GO:0014032]; neural plate mediolateral regionalization [GO:0021998]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; paraxial mesoderm structural organization [GO:0048352]; pharyngeal arch artery morphogenesis [GO:0061626]; pituitary gland development [GO:0021983]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac ventricle development [GO:1904414]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta2 production [GO:0032915]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein phosphorylation [GO:0006468]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cellular senescence [GO:2000772]; regulation of lateral mesodermal cell fate specification [GO:0048378]; roof of mouth development [GO:0060021]; somatic stem cell population maintenance [GO:0035019]; somitogenesis [GO:0001756]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tricuspid valve morphogenesis [GO:0003186]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]	dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; HFE-transferrin receptor complex [GO:1990712]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta receptor activity, type I [GO:0005025]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]	dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; HFE-transferrin receptor complex [GO:1990712]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta receptor activity, type I [GO:0005025]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; angiogenesis [GO:0001525]; atrioventricular node cell development [GO:0060928]; atrioventricular valve development [GO:0003171]; BMP signaling pathway [GO:0030509]; cardiac conduction system development [GO:0003161]; cardiac right ventricle morphogenesis [GO:0003215]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; central nervous system neuron differentiation [GO:0021953]; chondrocyte differentiation [GO:0002062]; developmental growth [GO:0048589]; dorsal aorta morphogenesis [GO:0035912]; dorsal/ventral axis specification [GO:0009950]; dorsal/ventral pattern formation [GO:0009953]; ectoderm development [GO:0007398]; embryonic digit morphogenesis [GO:0042733]; embryonic organ development [GO:0048568]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; epithelial cell proliferation [GO:0050673]; fibrous ring of heart morphogenesis [GO:1905285]; heart formation [GO:0060914]; hindlimb morphogenesis [GO:0035137]; immune response [GO:0006955]; in utero embryonic development [GO:0001701]; lateral mesoderm development [GO:0048368]; lung development [GO:0030324]; mesendoderm development [GO:0048382]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; Mullerian duct regression [GO:0001880]; negative regulation of gene expression [GO:0010629]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of neurogenesis [GO:0050768]; negative regulation of smooth muscle cell migration [GO:0014912]; neural crest cell development [GO:0014032]; neural plate mediolateral regionalization [GO:0021998]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; paraxial mesoderm structural organization [GO:0048352]; pharyngeal arch artery morphogenesis [GO:0061626]; pituitary gland development [GO:0021983]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac ventricle development [GO:1904414]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta2 production [GO:0032915]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein phosphorylation [GO:0006468]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cellular senescence [GO:2000772]; regulation of lateral mesodermal cell fate specification [GO:0048378]; roof of mouth development [GO:0060021]; somatic stem cell population maintenance [GO:0035019]; somitogenesis [GO:0001756]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tricuspid valve morphogenesis [GO:0003186]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P36898}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:P36895}.
P36896	reviewed	ACV1B_HUMAN	Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)	ACVR1B ACVRLK4 ALK4	Homo sapiens (Human)	505	FUNCTION: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. {ECO:0000269|PubMed:12364468, ECO:0000269|PubMed:12639945, ECO:0000269|PubMed:18039968, ECO:0000269|PubMed:20226172, ECO:0000269|PubMed:8196624, ECO:0000269|PubMed:9032295, ECO:0000269|PubMed:9892009}.		activin receptor signaling pathway [GO:0032924]; cellular response to growth factor stimulus [GO:0071363]; extrinsic apoptotic signaling pathway [GO:0097191]; G1/S transition of mitotic cell cycle [GO:0000082]; hair follicle development [GO:0001942]; in utero embryonic development [GO:0001701]; negative regulation of cell growth [GO:0030308]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; nodal signaling pathway [GO:0038092]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of trophoblast cell migration [GO:1901165]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]	activin receptor complex [GO:0048179]; cell surface [GO:0009986]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; I-SMAD binding [GO:0070411]; inhibin binding [GO:0034711]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; ubiquitin protein ligase binding [GO:0031625]	activin receptor complex [GO:0048179]; cell surface [GO:0009986]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; I-SMAD binding [GO:0070411]; inhibin binding [GO:0034711]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; ubiquitin protein ligase binding [GO:0031625]; activin receptor signaling pathway [GO:0032924]; cellular response to growth factor stimulus [GO:0071363]; extrinsic apoptotic signaling pathway [GO:0097191]; G1/S transition of mitotic cell cycle [GO:0000082]; hair follicle development [GO:0001942]; in utero embryonic development [GO:0001701]; negative regulation of cell growth [GO:0030308]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; nodal signaling pathway [GO:0038092]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of trophoblast cell migration [GO:1901165]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
P36897	reviewed	TGFR1_HUMAN	TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)	TGFBR1 ALK5 SKR4	Homo sapiens (Human)	503	FUNCTION: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:16754747, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:7774578, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:8980228, ECO:0000269|PubMed:9346908}.		activin receptor signaling pathway [GO:0032924]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; blastocyst development [GO:0001824]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell motility [GO:0048870]; cellular response to growth factor stimulus [GO:0071363]; cellular response to transforming growth factor beta stimulus [GO:0071560]; collagen fibril organization [GO:0030199]; coronary artery morphogenesis [GO:0060982]; embryonic cranial skeleton morphogenesis [GO:0048701]; endothelial cell activation [GO:0042118]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epicardium morphogenesis [GO:1905223]; epithelial to mesenchymal transition [GO:0001837]; extracellular structure organization [GO:0043062]; filopodium assembly [GO:0046847]; germ cell migration [GO:0008354]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; intracellular signal transduction [GO:0035556]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; male gonad development [GO:0008584]; mesenchymal cell differentiation [GO:0048762]; myofibroblast differentiation [GO:0036446]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; nervous system development [GO:0007399]; neuron fate commitment [GO:0048663]; parathyroid gland development [GO:0060017]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; pharyngeal system development [GO:0060037]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of tight junction disassembly [GO:1905075]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of protein ubiquitination [GO:0031396]; response to cholesterol [GO:0070723]; roof of mouth development [GO:0060021]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; thymus development [GO:0048538]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060]	activin receptor complex [GO:0048179]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; endosome [GO:0005768]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transforming growth factor beta ligand-receptor complex [GO:0070021]	activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; type II transforming growth factor beta receptor binding [GO:0005114]; ubiquitin protein ligase binding [GO:0031625]	activin receptor complex [GO:0048179]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; endosome [GO:0005768]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transforming growth factor beta ligand-receptor complex [GO:0070021]; activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; type II transforming growth factor beta receptor binding [GO:0005114]; ubiquitin protein ligase binding [GO:0031625]; activin receptor signaling pathway [GO:0032924]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; blastocyst development [GO:0001824]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell motility [GO:0048870]; cellular response to growth factor stimulus [GO:0071363]; cellular response to transforming growth factor beta stimulus [GO:0071560]; collagen fibril organization [GO:0030199]; coronary artery morphogenesis [GO:0060982]; embryonic cranial skeleton morphogenesis [GO:0048701]; endothelial cell activation [GO:0042118]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epicardium morphogenesis [GO:1905223]; epithelial to mesenchymal transition [GO:0001837]; extracellular structure organization [GO:0043062]; filopodium assembly [GO:0046847]; germ cell migration [GO:0008354]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; intracellular signal transduction [GO:0035556]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; male gonad development [GO:0008584]; mesenchymal cell differentiation [GO:0048762]; myofibroblast differentiation [GO:0036446]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; nervous system development [GO:0007399]; neuron fate commitment [GO:0048663]; parathyroid gland development [GO:0060017]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; pharyngeal system development [GO:0060037]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of tight junction disassembly [GO:1905075]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of protein ubiquitination [GO:0031396]; response to cholesterol [GO:0070723]; roof of mouth development [GO:0060021]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; thymus development [GO:0048538]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:9472030}; Single-pass type I membrane protein {ECO:0000269|PubMed:9472030}. Cell junction, tight junction {ECO:0000269|PubMed:15761148}. Cell surface {ECO:0000269|PubMed:25893292}. Membrane raft {ECO:0000269|PubMed:25893292}.
P36941	reviewed	TNR3_HUMAN	Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III)	LTBR D12S370 TNFCR TNFR3 TNFRSF3	Homo sapiens (Human)	435	FUNCTION: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. {ECO:0000269|PubMed:10799510, ECO:0000269|PubMed:8171323}.		apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; hematopoietic or lymphoid organ development [GO:0048534]; immune response [GO:0006955]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of JNK cascade [GO:0046330]; signal transduction [GO:0007165]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; hematopoietic or lymphoid organ development [GO:0048534]; immune response [GO:0006955]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of JNK cascade [GO:0046330]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P36952	reviewed	SPB5_HUMAN	Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5)	SERPINB5 PI5	Homo sapiens (Human)	375	FUNCTION: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.		extracellular matrix organization [GO:0030198]; morphogenesis of an epithelium [GO:0002009]; prostate gland morphogenesis [GO:0060512]; regulation of epithelial cell proliferation [GO:0050678]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; sarcoplasm [GO:0016528]	serine-type endopeptidase inhibitor activity [GO:0004867]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; sarcoplasm [GO:0016528]; serine-type endopeptidase inhibitor activity [GO:0004867]; extracellular matrix organization [GO:0030198]; morphogenesis of an epithelium [GO:0002009]; prostate gland morphogenesis [GO:0060512]; regulation of epithelial cell proliferation [GO:0050678]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P36954	reviewed	RPB9_HUMAN	DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5)	POLR2I	Homo sapiens (Human)	125	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.		maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II [GO:0001193]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]	DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II [GO:0001193]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:9852112}.
P36955	reviewed	PEDF_HUMAN	Pigment epithelium-derived factor (PEDF) (Cell proliferation-inducing gene 35 protein) (EPC-1) (Serpin F1)	SERPINF1 PEDF PIG35	Homo sapiens (Human)	418	FUNCTION: Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269|PubMed:7592790, ECO:0000269|PubMed:8226833}.		cellular response to cobalt ion [GO:0071279]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to retinoic acid [GO:0071300]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of gene expression [GO:0010629]; ovulation cycle [GO:0042698]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron projection development [GO:0010976]; response to acidic pH [GO:0010447]; response to arsenic-containing substance [GO:0046685]; response to peptide [GO:1901652]; retina development in camera-type eye [GO:0060041]; short-term memory [GO:0007614]	axon hillock [GO:0043203]; basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; melanosome [GO:0042470]; perinuclear region of cytoplasm [GO:0048471]	serine-type endopeptidase inhibitor activity [GO:0004867]	axon hillock [GO:0043203]; basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; melanosome [GO:0042470]; perinuclear region of cytoplasm [GO:0048471]; serine-type endopeptidase inhibitor activity [GO:0004867]; cellular response to cobalt ion [GO:0071279]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to retinoic acid [GO:0071300]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of gene expression [GO:0010629]; ovulation cycle [GO:0042698]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron projection development [GO:0010976]; response to acidic pH [GO:0010447]; response to arsenic-containing substance [GO:0046685]; response to peptide [GO:1901652]; retina development in camera-type eye [GO:0060041]; short-term memory [GO:0007614]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in stage I melanosomes.
P36956	reviewed	SRBP1_HUMAN	Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]	SREBF1 BHLHD1 SREBP1	Homo sapiens (Human)	1147	FUNCTION: [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 1]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:8402897, PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:8402897, PubMed:12177166). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:8402897, PubMed:12177166, PubMed:32322062). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:8402897}.; FUNCTION: [Isoform SREBP-1A]: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:12177166, PubMed:32497488). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32497488}.; FUNCTION: [Isoform SREBP-1C]: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (PubMed:12177166). Strongly activates global lipid synthesis in rapidly growing cells (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166}.; FUNCTION: [Isoform SREBP-1aDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}.; FUNCTION: [Isoform SREBP-1cDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}.		cellular response to fatty acid [GO:0071398]; cellular response to starvation [GO:0009267]; cholesterol biosynthetic process [GO:0006695]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; insulin receptor signaling pathway [GO:0008286]; insulin secretion [GO:0030073]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of insulin secretion [GO:0046676]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of triglyceride metabolic process [GO:0090209]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of fatty acid metabolic process [GO:0019217]; regulation of heart rate by chemical signal [GO:0003062]; regulation of lipid storage [GO:0010883]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to glucagon [GO:0033762]; response to glucose [GO:0009749]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; SREBP signaling pathway [GO:0032933]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; sterol response element binding [GO:0032810]; transcription coregulator binding [GO:0001221]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; sterol response element binding [GO:0032810]; transcription coregulator binding [GO:0001221]; cellular response to fatty acid [GO:0071398]; cellular response to starvation [GO:0009267]; cholesterol biosynthetic process [GO:0006695]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; insulin receptor signaling pathway [GO:0008286]; insulin secretion [GO:0030073]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of insulin secretion [GO:0046676]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of triglyceride metabolic process [GO:0090209]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of fatty acid metabolic process [GO:0019217]; regulation of heart rate by chemical signal [GO:0003062]; regulation of lipid storage [GO:0010883]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to glucagon [GO:0033762]; response to glucose [GO:0009749]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; SREBP signaling pathway [GO:0032933]	SUBCELLULAR LOCATION: [Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12202038}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9WTN3}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q9WTN3}; Multi-pass membrane protein {ECO:0000255}. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum. Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed. {ECO:0000250|UniProtKB:Q9WTN3}.; SUBCELLULAR LOCATION: [Processed sterol regulatory element-binding protein 1]: Nucleus {ECO:0000269|PubMed:11477106, ECO:0000269|PubMed:32322062}.; SUBCELLULAR LOCATION: [Isoform SREBP-1aDelta]: Nucleus {ECO:0000269|PubMed:18267114, ECO:0000269|PubMed:32497488}.; SUBCELLULAR LOCATION: [Isoform SREBP-1cDelta]: Nucleus {ECO:0000269|PubMed:18267114, ECO:0000269|PubMed:32497488}.
P36957	reviewed	ODO2_HUMAN	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)	DLST DLTS	Homo sapiens (Human)	453	FUNCTION: Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711, PubMed:30929736). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). {ECO:0000269|PubMed:29211711, ECO:0000269|PubMed:30929736}.		2-oxoglutarate metabolic process [GO:0006103]; generation of precursor metabolites and energy [GO:0006091]; histone succinylation [GO:0106077]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252]	acyltransferase activity [GO:0016746]; dihydrolipoyllysine-residue succinyltransferase activity [GO:0004149]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252]; acyltransferase activity [GO:0016746]; dihydrolipoyllysine-residue succinyltransferase activity [GO:0004149]; 2-oxoglutarate metabolic process [GO:0006103]; generation of precursor metabolites and energy [GO:0006091]; histone succinylation [GO:0106077]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:29211711}. Nucleus {ECO:0000269|PubMed:29211711}. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation. {ECO:0000269|PubMed:29211711}.
P36959	reviewed	GMPR1_HUMAN	GMP reductase 1 (GMPR 1) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1)	GMPR GMPR1	Homo sapiens (Human)	345	FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. {ECO:0000255|HAMAP-Rule:MF_03195}.		purine nucleobase metabolic process [GO:0006144]; purine nucleotide metabolic process [GO:0006163]; response to cold [GO:0009409]	cytosol [GO:0005829]; GMP reductase complex [GO:1902560]	GMP reductase activity [GO:0003920]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; GMP reductase complex [GO:1902560]; GMP reductase activity [GO:0003920]; metal ion binding [GO:0046872]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide metabolic process [GO:0006163]; response to cold [GO:0009409]	
P36969	reviewed	GPX4_HUMAN	Phospholipid hydroperoxide glutathione peroxidase (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4)	GPX4	Homo sapiens (Human)	197	FUNCTION: Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:24439385). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (PubMed:11115402). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity). {ECO:0000250|UniProtKB:O70325, ECO:0000250|UniProtKB:P36968, ECO:0000269|PubMed:11115402, ECO:0000269|PubMed:24439385}.		arachidonic acid metabolic process [GO:0019369]; chromatin organization [GO:0006325]; glutathione metabolic process [GO:0006749]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of ferroptosis [GO:0110076]; phospholipid metabolic process [GO:0006644]; protein polymerization [GO:0051258]; response to estradiol [GO:0032355]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	glutathione peroxidase activity [GO:0004602]; identical protein binding [GO:0042802]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066]; selenium binding [GO:0008430]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; glutathione peroxidase activity [GO:0004602]; identical protein binding [GO:0042802]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066]; selenium binding [GO:0008430]; arachidonic acid metabolic process [GO:0019369]; chromatin organization [GO:0006325]; glutathione metabolic process [GO:0006749]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of ferroptosis [GO:0110076]; phospholipid metabolic process [GO:0006644]; protein polymerization [GO:0051258]; response to estradiol [GO:0032355]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion {ECO:0000250|UniProtKB:O70325}.; SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm {ECO:0000269|PubMed:11115402}.
P36980	reviewed	FHR2_HUMAN	Complement factor H-related protein 2 (FHR-2) (DDESK59) (H factor-like 3) (H factor-like protein 2)	CFHR2 CFHL2 FHR2 HFL3	Homo sapiens (Human)	270	FUNCTION: Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. {ECO:0000269|PubMed:23487775}.		complement activation [GO:0006956]; cytolysis by host of symbiont cells [GO:0051838]; negative regulation of protein binding [GO:0032091]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]	complement component C3b binding [GO:0001851]; identical protein binding [GO:0042802]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]; complement component C3b binding [GO:0001851]; identical protein binding [GO:0042802]; complement activation [GO:0006956]; cytolysis by host of symbiont cells [GO:0051838]; negative regulation of protein binding [GO:0032091]	SUBCELLULAR LOCATION: Secreted.
P37023	reviewed	ACVL1_HUMAN	Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)	ACVRL1 ACVRLK1 ALK1	Homo sapiens (Human)	503	FUNCTION: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. {ECO:0000269|PubMed:22718755, ECO:0000269|PubMed:22799562, ECO:0000269|PubMed:26176610}.		angiogenesis [GO:0001525]; artery development [GO:0060840]; blood circulation [GO:0008015]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; blood vessel maturation [GO:0001955]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dorsal aorta morphogenesis [GO:0035912]; dorsal/ventral pattern formation [GO:0009953]; endocardial cushion morphogenesis [GO:0003203]; endothelial tube morphogenesis [GO:0061154]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of gene expression [GO:0010629]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of endothelial cell proliferation [GO:0001936]; response to hypoxia [GO:0001666]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]; venous blood vessel development [GO:0060841]; wound healing, spreading of epidermal cells [GO:0035313]	BMP receptor complex [GO:0070724]; cell surface [GO:0009986]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]	BMP receptor complex [GO:0070724]; cell surface [GO:0009986]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; angiogenesis [GO:0001525]; artery development [GO:0060840]; blood circulation [GO:0008015]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; blood vessel maturation [GO:0001955]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dorsal aorta morphogenesis [GO:0035912]; dorsal/ventral pattern formation [GO:0009953]; endocardial cushion morphogenesis [GO:0003203]; endothelial tube morphogenesis [GO:0061154]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of gene expression [GO:0010629]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of endothelial cell proliferation [GO:0001936]; response to hypoxia [GO:0001666]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]; venous blood vessel development [GO:0060841]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26176610}; Single-pass type I membrane protein {ECO:0000255}.
P37058	reviewed	DHB3_HUMAN	17-beta-hydroxysteroid dehydrogenase type 3 (17-beta-HSD 3) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 2) (Testicular 17-beta-hydroxysteroid dehydrogenase) (Testosterone 17-beta-dehydrogenase 3) (EC 1.1.1.64)	HSD17B3 EDH17B3 SDR12C2	Homo sapiens (Human)	310	FUNCTION: Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids (PubMed:8075637, PubMed:16216911, PubMed:27927697, PubMed:26545797). Favors the reduction of androstenedione to testosterone (PubMed:16216911, PubMed:27927697, PubMed:26545797). Testosterone is the key androgen driving male development and function (PubMed:8075637). Uses NADPH while the two other EDH17B enzymes use NADH (PubMed:26545797, PubMed:8075637, PubMed:16216911). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17 (PubMed:16216911). Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911, PubMed:27927697). {ECO:0000269|PubMed:16216911, ECO:0000269|PubMed:26545797, ECO:0000269|PubMed:27927697, ECO:0000269|PubMed:8075637}.		androgen biosynthetic process [GO:0006702]; male genitalia development [GO:0030539]; steroid biosynthetic process [GO:0006694]; testosterone biosynthetic process [GO:0061370]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	17-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0072582]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase [NAD(P)] activity [GO:0030283]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; 17-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0072582]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase [NAD(P)] activity [GO:0030283]; androgen biosynthetic process [GO:0006702]; male genitalia development [GO:0030539]; steroid biosynthetic process [GO:0006694]; testosterone biosynthetic process [GO:0061370]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:16216911, ECO:0000269|PubMed:26545797}.
P37059	reviewed	DHB2_HUMAN	17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239)	HSD17B2 EDH17B2 SDR9C2	Homo sapiens (Human)	387	FUNCTION: Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000269|PubMed:10385431, ECO:0000269|PubMed:11940569, ECO:0000269|PubMed:8099587}.		androgen metabolic process [GO:0008209]; estrogen biosynthetic process [GO:0006703]; in utero embryonic development [GO:0001701]; placenta development [GO:0001890]; response to retinoic acid [GO:0032526]; steroid metabolic process [GO:0008202]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity [GO:0047006]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; testosterone dehydrogenase (NAD+) activity [GO:0047035]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity [GO:0047006]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; androgen metabolic process [GO:0008209]; estrogen biosynthetic process [GO:0006703]; in utero embryonic development [GO:0001701]; placenta development [GO:0001890]; response to retinoic acid [GO:0032526]; steroid metabolic process [GO:0008202]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10385431}; Single-pass type II membrane protein {ECO:0000305}.
P37088	reviewed	SCNNA_HUMAN	Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (ENaCA) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)	SCNN1A SCNN1	Homo sapiens (Human)	669	FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. {ECO:0000269|PubMed:24124190, ECO:0000269|PubMed:28710092, ECO:0000269|PubMed:8278374}.	MISCELLANEOUS: [Isoform 3]: Does not give rise to amiloride-sensitive ion current. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Amiloride-sensitive ion current is nearly abolished. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Does not give rise to amiloride-sensitive ion current. {ECO:0000305}.	cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; intracellular sodium ion homeostasis [GO:0006883]; multicellular organismal-level water homeostasis [GO:0050891]; regulation of blood pressure [GO:0008217]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]	acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]; sperm principal piece [GO:0097228]	ligand-gated sodium channel activity [GO:0015280]; WW domain binding [GO:0050699]	acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]; sperm principal piece [GO:0097228]; ligand-gated sodium channel activity [GO:0015280]; WW domain binding [GO:0050699]; cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; intracellular sodium ion homeostasis [GO:0006883]; multicellular organismal-level water homeostasis [GO:0050891]; regulation of blood pressure [GO:0008217]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:22207244, ECO:0000269|PubMed:28130590}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}. Cell projection, cilium {ECO:0000269|PubMed:22207244}. Cytoplasmic granule {ECO:0000269|PubMed:28130590}. Cytoplasm {ECO:0000269|PubMed:28130590}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P37089}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:P37089}. Note=In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non-ciliated epithelial cells, restricted to apical surfaces. In epidermis, located nearly uniformly in the cytoplasm in a granular distribution (PubMed:28130590). In sebaceous glands, observed only in the cytoplasmic space in between the lipid vesicles (PubMed:28130590). In eccrine sweat glands, mainly located at the apical surface of the cells facing the lumen (PubMed:28130590). In skin, in arrector pili muscle cells and in adipocytes, located in the cytoplasm and colocalized with actin fibers (PubMed:28130590). In spermatogonia, spermatocytes and round spermatids, located in the cytoplasm (By similarity). Prior to spermiation, location shifts from the cytoplasm to the spermatid tail (By similarity). In spermatozoa, localizes at the acrosome and the central region of the sperm flagellum (By similarity). {ECO:0000250|UniProtKB:P37089, ECO:0000269|PubMed:22207244, ECO:0000269|PubMed:24124190, ECO:0000269|PubMed:28130590}.
P37108	reviewed	SRP14_HUMAN	Signal recognition particle 14 kDa protein (SRP14) (18 kDa Alu RNA-binding protein)	SRP14	Homo sapiens (Human)	136	FUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:11089964). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (PubMed:11089964). The complex of SRP9 and SRP14 is required for SRP RNA binding (PubMed:11089964). {ECO:0000269|PubMed:11089964}.		cotranslational protein targeting to membrane [GO:0006613]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]	7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; RNA binding [GO:0003723]; cotranslational protein targeting to membrane [GO:0006613]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	SUBCELLULAR LOCATION: Cytoplasm.
P37173	reviewed	TGFR2_HUMAN	TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)	TGFBR2	Homo sapiens (Human)	567	FUNCTION: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. {ECO:0000269|PubMed:7774578}.; FUNCTION: [Isoform 1]: Has transforming growth factor beta-activated receptor activity. {ECO:0000269|PubMed:8635485}.; FUNCTION: [Isoform 2]: Has transforming growth factor beta-activated receptor activity. {ECO:0000269|PubMed:8635485}.; FUNCTION: [Isoform 3]: Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1. {ECO:0000269|PubMed:34568316}.		activation of protein kinase activity [GO:0032147]; aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; atrioventricular valve morphogenesis [GO:0003181]; blood vessel development [GO:0001568]; brain development [GO:0007420]; branching involved in blood vessel morphogenesis [GO:0001569]; bronchus morphogenesis [GO:0060434]; cardiac left ventricle morphogenesis [GO:0003214]; cellular response to growth factor stimulus [GO:0071363]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic hemopoiesis [GO:0035162]; endocardial cushion fusion [GO:0003274]; gastrulation [GO:0007369]; growth plate cartilage chondrocyte growth [GO:0003430]; heart development [GO:0007507]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; inferior endocardial cushion morphogenesis [GO:1905317]; Langerhans cell differentiation [GO:0061520]; lens development in camera-type eye [GO:0002088]; lens fiber cell apoptotic process [GO:1990086]; lung lobe morphogenesis [GO:0060463]; mammary gland morphogenesis [GO:0060443]; membranous septum morphogenesis [GO:0003149]; miRNA transport [GO:1990428]; myeloid dendritic cell differentiation [GO:0043011]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell tolerance induction [GO:0002663]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction to self antigen [GO:0002651]; protein phosphorylation [GO:0006468]; regulation of cell population proliferation [GO:0042127]; regulation of gene expression [GO:0010468]; regulation of stem cell proliferation [GO:0072091]; response to cholesterol [GO:0070723]; response to xenobiotic stimulus [GO:0009410]; roof of mouth development [GO:0060021]; secondary palate development [GO:0062009]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; trachea formation [GO:0060440]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tricuspid valve morphogenesis [GO:0003186]; vasculogenesis [GO:0001570]; ventricular septum morphogenesis [GO:0060412]	caveola [GO:0005901]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transforming growth factor beta ligand-receptor complex [GO:0070021]	activin binding [GO:0048185]; activin receptor activity [GO:0017002]; ATP binding [GO:0005524]; glycosaminoglycan binding [GO:0005539]; kinase activator activity [GO:0019209]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type II [GO:0005026]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; type I transforming growth factor beta receptor binding [GO:0034713]; type III transforming growth factor beta receptor binding [GO:0034714]	caveola [GO:0005901]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transforming growth factor beta ligand-receptor complex [GO:0070021]; activin binding [GO:0048185]; activin receptor activity [GO:0017002]; ATP binding [GO:0005524]; glycosaminoglycan binding [GO:0005539]; kinase activator activity [GO:0019209]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type II [GO:0005026]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; type I transforming growth factor beta receptor binding [GO:0034713]; type III transforming growth factor beta receptor binding [GO:0034714]; activation of protein kinase activity [GO:0032147]; aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; atrioventricular valve morphogenesis [GO:0003181]; blood vessel development [GO:0001568]; brain development [GO:0007420]; branching involved in blood vessel morphogenesis [GO:0001569]; bronchus morphogenesis [GO:0060434]; cardiac left ventricle morphogenesis [GO:0003214]; cellular response to growth factor stimulus [GO:0071363]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic hemopoiesis [GO:0035162]; endocardial cushion fusion [GO:0003274]; gastrulation [GO:0007369]; growth plate cartilage chondrocyte growth [GO:0003430]; heart development [GO:0007507]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; inferior endocardial cushion morphogenesis [GO:1905317]; Langerhans cell differentiation [GO:0061520]; lens development in camera-type eye [GO:0002088]; lens fiber cell apoptotic process [GO:1990086]; lung lobe morphogenesis [GO:0060463]; mammary gland morphogenesis [GO:0060443]; membranous septum morphogenesis [GO:0003149]; miRNA transport [GO:1990428]; myeloid dendritic cell differentiation [GO:0043011]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell tolerance induction [GO:0002663]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction to self antigen [GO:0002651]; protein phosphorylation [GO:0006468]; regulation of cell population proliferation [GO:0042127]; regulation of gene expression [GO:0010468]; regulation of stem cell proliferation [GO:0072091]; response to cholesterol [GO:0070723]; response to xenobiotic stimulus [GO:0009410]; roof of mouth development [GO:0060021]; secondary palate development [GO:0062009]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; trachea formation [GO:0060440]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tricuspid valve morphogenesis [GO:0003186]; vasculogenesis [GO:0001570]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1310899, ECO:0000269|PubMed:25893292}; Single-pass type I membrane protein {ECO:0000269|PubMed:1310899}. Membrane raft {ECO:0000269|PubMed:25893292}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:34568316}.
P37198	reviewed	NUP62_HUMAN	Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62)	NUP62	Homo sapiens (Human)	522	FUNCTION: Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}.		cell surface receptor signaling pathway [GO:0007166]; cellular senescence [GO:0090398]; centriole assembly [GO:0098534]; centrosome cycle [GO:0007098]; mitotic centrosome separation [GO:0007100]; mitotic metaphase chromosome alignment [GO:0007080]; mRNA transport [GO:0051028]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of programmed cell death [GO:0043069]; negative regulation of Ras protein signal transduction [GO:0046580]; nucleocytoplasmic transport [GO:0006913]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of centriole replication [GO:0046601]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of mitotic cytokinetic process [GO:1903438]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of protein localization to centrosome [GO:1904781]; protein import into nucleus [GO:0006606]; regulation of mitotic spindle organization [GO:0060236]; regulation of Ras protein signal transduction [GO:0046578]; regulation of signal transduction [GO:0009966]; RNA export from nucleus [GO:0006405]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; spindle pole [GO:0000922]	chromatin binding [GO:0003682]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; phospholipid binding [GO:0005543]; PTB domain binding [GO:0051425]; SH2 domain binding [GO:0042169]; signaling receptor complex adaptor activity [GO:0030159]; structural constituent of nuclear pore [GO:0017056]; ubiquitin binding [GO:0043130]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; spindle pole [GO:0000922]; chromatin binding [GO:0003682]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; phospholipid binding [GO:0005543]; PTB domain binding [GO:0051425]; SH2 domain binding [GO:0042169]; signaling receptor complex adaptor activity [GO:0030159]; structural constituent of nuclear pore [GO:0017056]; ubiquitin binding [GO:0043130]; cell surface receptor signaling pathway [GO:0007166]; cellular senescence [GO:0090398]; centriole assembly [GO:0098534]; centrosome cycle [GO:0007098]; mitotic centrosome separation [GO:0007100]; mitotic metaphase chromosome alignment [GO:0007080]; mRNA transport [GO:0051028]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of programmed cell death [GO:0043069]; negative regulation of Ras protein signal transduction [GO:0046580]; nucleocytoplasmic transport [GO:0006913]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of centriole replication [GO:0046601]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of mitotic cytokinetic process [GO:1903438]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of protein localization to centrosome [GO:1904781]; protein import into nucleus [GO:0006606]; regulation of mitotic spindle organization [GO:0060236]; regulation of Ras protein signal transduction [GO:0046578]; regulation of signal transduction [GO:0009966]; RNA export from nucleus [GO:0006405]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:1915414}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:24107630}. Nucleus envelope {ECO:0000269|PubMed:24107630}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:24107630}. Note=Central region of the nuclear pore, within the transporter (PubMed:1915414). During mitotic cell division, it associates with the poles of the mitotic spindle (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}.
P37231	reviewed	PPARG_HUMAN	Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)	PPARG NR1C3	Homo sapiens (Human)	505	FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity). {ECO:0000250|UniProtKB:P37238, ECO:0000269|PubMed:16150867, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:9065481}.; FUNCTION: (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. {ECO:0000269|PubMed:25504154}.	MISCELLANEOUS: [Isoform 3]: Exhibits dominant negative activity over isoform 1. {ECO:0000305}.	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cell maturation [GO:0048469]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; epithelial cell differentiation [GO:0030855]; fatty acid metabolic process [GO:0006631]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; innate immune response [GO:0045087]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; lipoprotein transport [GO:0042953]; long-chain fatty acid transport [GO:0015909]; macrophage derived foam cell differentiation [GO:0010742]; monocyte differentiation [GO:0030224]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of connective tissue replacement involved in inflammatory response wound healing [GO:1904597]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; negative regulation of sequestering of triglyceride [GO:0010891]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; placenta development [GO:0001890]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of gene expression [GO:0010628]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; regulation of blood pressure [GO:0008217]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of cholesterol transporter activity [GO:0060694]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipid [GO:0033993]; response to nutrient [GO:0007584]; retinoic acid receptor signaling pathway [GO:0048384]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; white fat cell differentiation [GO:0050872]	chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575]	alpha-actinin binding [GO:0051393]; arachidonic acid binding [GO:0050544]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding domain binding [GO:0050692]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; LBD domain binding [GO:0050693]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; nucleic acid binding [GO:0003676]; peptide binding [GO:0042277]; prostaglandin receptor activity [GO:0004955]; protein self-association [GO:0043621]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575]; alpha-actinin binding [GO:0051393]; arachidonic acid binding [GO:0050544]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding domain binding [GO:0050692]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; LBD domain binding [GO:0050693]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; nucleic acid binding [GO:0003676]; peptide binding [GO:0042277]; prostaglandin receptor activity [GO:0004955]; protein self-association [GO:0043621]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cell maturation [GO:0048469]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; epithelial cell differentiation [GO:0030855]; fatty acid metabolic process [GO:0006631]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; innate immune response [GO:0045087]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; lipoprotein transport [GO:0042953]; long-chain fatty acid transport [GO:0015909]; macrophage derived foam cell differentiation [GO:0010742]; monocyte differentiation [GO:0030224]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of connective tissue replacement involved in inflammatory response wound healing [GO:1904597]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; negative regulation of sequestering of triglyceride [GO:0010891]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; placenta development [GO:0001890]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of gene expression [GO:0010628]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; regulation of blood pressure [GO:0008217]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of cholesterol transporter activity [GO:0060694]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipid [GO:0033993]; response to nutrient [GO:0007584]; retinoic acid receptor signaling pathway [GO:0048384]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation.
P37235	reviewed	HPCL1_HUMAN	Hippocalcin-like protein 1 (Calcium-binding protein BDR-1) (HLP2) (Visinin-like protein 3) (VILIP-3)	HPCAL1 BDR1	Homo sapiens (Human)	193	FUNCTION: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.	MISCELLANEOUS: Probably binds two or three calcium ions. {ECO:0000250}.		membrane [GO:0016020]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
P37268	reviewed	FDFT_HUMAN	Squalene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase 1)	FDFT1	Homo sapiens (Human)	417	FUNCTION: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. {ECO:0000269|PubMed:10896663, ECO:0000269|PubMed:24531458}.		cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate metabolic process [GO:0045338]; steroid biosynthetic process [GO:0006694]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	farnesyl-diphosphate farnesyltransferase activity [GO:0004310]; metal ion binding [GO:0046872]; squalene synthase activity [GO:0051996]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; farnesyl-diphosphate farnesyltransferase activity [GO:0004310]; metal ion binding [GO:0046872]; squalene synthase activity [GO:0051996]; cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate metabolic process [GO:0045338]; steroid biosynthetic process [GO:0006694]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q02769}; Multi-pass membrane protein {ECO:0000255}.
P37275	reviewed	ZEB1_HUMAN	Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8)	ZEB1 AREB6 TCF8	Homo sapiens (Human)	1124	FUNCTION: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}.		anatomical structure development [GO:0048856]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cellular response to amino acid stimulus [GO:0071230]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cochlea morphogenesis [GO:0090103]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic skeletal system morphogenesis [GO:0048704]; forebrain development [GO:0030900]; keratinocyte proliferation [GO:0043616]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pattern specification process [GO:0007389]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mesenchymal cell proliferation [GO:0010464]; regulation of smooth muscle cell differentiation [GO:0051150]; regulation of T cell differentiation in thymus [GO:0033081]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to activity [GO:0014823]; response to nutrient levels [GO:0031667]; semicircular canal morphogenesis [GO:0048752]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; anatomical structure development [GO:0048856]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cellular response to amino acid stimulus [GO:0071230]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cochlea morphogenesis [GO:0090103]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic skeletal system morphogenesis [GO:0048704]; forebrain development [GO:0030900]; keratinocyte proliferation [GO:0043616]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pattern specification process [GO:0007389]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mesenchymal cell proliferation [GO:0010464]; regulation of smooth muscle cell differentiation [GO:0051150]; regulation of T cell differentiation in thymus [GO:0033081]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to activity [GO:0014823]; response to nutrient levels [GO:0031667]; semicircular canal morphogenesis [GO:0048752]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:25190660}.
P37287	reviewed	PIGA_HUMAN	Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (EC 2.4.1.198) (GlcNAc-PI synthesis protein) (Phosphatidylinositol-glycan biosynthesis class A protein) (PIG-A)	PIGA	Homo sapiens (Human)	484	FUNCTION: Catalytic subunit of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. {ECO:0000305|PubMed:16162815}.		cellular response to leukemia inhibitory factor [GO:1990830]; preassembly of GPI anchor in ER membrane [GO:0016254]	endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; membrane [GO:0016020]	phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176]; UDP-glycosyltransferase activity [GO:0008194]	endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; membrane [GO:0016020]; phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176]; UDP-glycosyltransferase activity [GO:0008194]; cellular response to leukemia inhibitory factor [GO:1990830]; preassembly of GPI anchor in ER membrane [GO:0016254]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein.
P37288	reviewed	V1AR_HUMAN	Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor)	AVPR1A AVPR1	Homo sapiens (Human)	418	FUNCTION: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. {ECO:0000269|PubMed:12082568}.	MISCELLANEOUS: Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A. One such allelic variant has been linked to autism.	activation of phospholipase C activity [GO:0007202]; blood circulation [GO:0008015]; calcium-mediated signaling [GO:0019722]; cellular response to hormone stimulus [GO:0032870]; cellular response to water deprivation [GO:0042631]; G protein-coupled receptor signaling pathway [GO:0007186]; generation of precursor metabolites and energy [GO:0006091]; grooming behavior [GO:0007625]; maternal aggressive behavior [GO:0002125]; maternal behavior [GO:0042711]; myotube differentiation [GO:0014902]; negative regulation of female receptivity [GO:0007621]; negative regulation of transmission of nerve impulse [GO:0051970]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of heart rate [GO:0010460]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; response to corticosterone [GO:0051412]; social behavior [GO:0035176]; sperm ejaculation [GO:0042713]; telencephalon development [GO:0021537]; transport across blood-brain barrier [GO:0150104]	endocytic vesicle [GO:0030139]; endosome [GO:0005768]; plasma membrane [GO:0005886]	peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; protein kinase C binding [GO:0005080]; V1A vasopressin receptor binding [GO:0031894]; vasopressin receptor activity [GO:0005000]	endocytic vesicle [GO:0030139]; endosome [GO:0005768]; plasma membrane [GO:0005886]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; protein kinase C binding [GO:0005080]; V1A vasopressin receptor binding [GO:0031894]; vasopressin receptor activity [GO:0005000]; activation of phospholipase C activity [GO:0007202]; blood circulation [GO:0008015]; calcium-mediated signaling [GO:0019722]; cellular response to hormone stimulus [GO:0032870]; cellular response to water deprivation [GO:0042631]; G protein-coupled receptor signaling pathway [GO:0007186]; generation of precursor metabolites and energy [GO:0006091]; grooming behavior [GO:0007625]; maternal aggressive behavior [GO:0002125]; maternal behavior [GO:0042711]; myotube differentiation [GO:0014902]; negative regulation of female receptivity [GO:0007621]; negative regulation of transmission of nerve impulse [GO:0051970]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of heart rate [GO:0010460]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; response to corticosterone [GO:0051412]; social behavior [GO:0035176]; sperm ejaculation [GO:0042713]; telencephalon development [GO:0021537]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P37802	reviewed	TAGL2_HUMAN	Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog)	TAGLN2 KIAA0120 CDABP0035	Homo sapiens (Human)	199			actin filament organization [GO:0007015]; epithelial cell differentiation [GO:0030855]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; actin filament organization [GO:0007015]; epithelial cell differentiation [GO:0030855]	
P37837	reviewed	TALDO_HUMAN	Transaldolase (EC 2.2.1.2)	TALDO1 TAL TALDO TALDOR	Homo sapiens (Human)	337	FUNCTION: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:8955144, PubMed:18687684). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q93092, ECO:0000269|PubMed:18687684, ECO:0000269|PubMed:8955144}.		carbohydrate metabolic process [GO:0005975]; fructose 6-phosphate metabolic process [GO:0006002]; glyceraldehyde-3-phosphate metabolic process [GO:0019682]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	monosaccharide binding [GO:0048029]; transaldolase activity [GO:0004801]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; monosaccharide binding [GO:0048029]; transaldolase activity [GO:0004801]; carbohydrate metabolic process [GO:0005975]; fructose 6-phosphate metabolic process [GO:0006002]; glyceraldehyde-3-phosphate metabolic process [GO:0019682]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:Q93092}. Cytoplasm {ECO:0000250|UniProtKB:Q93092}. Note=Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent manner. Exported into the cytoplasm by CRM1. {ECO:0000250|UniProtKB:Q93092}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q93092}. Note=Imported into the nucleus when incorporated in isoform 1/isoform 2 homodimer. {ECO:0000250|UniProtKB:Q93092}.
P37840	reviewed	SYUA_HUMAN	Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)	SNCA NACP PARK1	Homo sapiens (Human)	140	FUNCTION: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:28288128, PubMed:30404828, PubMed:20798282, PubMed:26442590). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). {ECO:0000269|PubMed:20798282, ECO:0000269|PubMed:26442590, ECO:0000269|PubMed:28288128, ECO:0000269|PubMed:30404828}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; adult locomotory behavior [GO:0008344]; amyloid fibril formation [GO:1990000]; cellular response to copper ion [GO:0071280]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to oxidative stress [GO:0034599]; chemical synaptic transmission [GO:0007268]; dopamine biosynthetic process [GO:0042416]; dopamine uptake involved in synaptic transmission [GO:0051583]; excitatory postsynaptic potential [GO:0060079]; fatty acid metabolic process [GO:0006631]; localization [GO:0051179]; long-term synaptic potentiation [GO:0060291]; microglial cell activation [GO:0001774]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial membrane organization [GO:0007006]; negative regulation of apoptotic process [GO:0043066]; negative regulation of chaperone-mediated autophagy [GO:1904715]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of dopamine uptake involved in synaptic transmission [GO:0051585]; negative regulation of exocytosis [GO:0045920]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902957]; negative regulation of monooxygenase activity [GO:0032769]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of norepinephrine uptake [GO:0051622]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of serotonin uptake [GO:0051612]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transporter activity [GO:0032410]; neuron apoptotic process [GO:0051402]; neutral lipid metabolic process [GO:0006638]; phospholipid metabolic process [GO:0006644]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endocytosis [GO:0045807]; positive regulation of exocytosis [GO:0045921]; positive regulation of glutathione peroxidase activity [GO:1903284]; positive regulation of hydrogen peroxide catabolic process [GO:1903285]; positive regulation of inflammatory response [GO:0050729]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of receptor recycling [GO:0001921]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of SNARE complex assembly [GO:0035543]; protein destabilization [GO:0031648]; protein tetramerization [GO:0051262]; receptor internalization [GO:0031623]; regulation of acyl-CoA biosynthetic process [GO:0050812]; regulation of dopamine secretion [GO:0014059]; regulation of glutamate secretion [GO:0014048]; regulation of locomotion [GO:0040012]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of macrophage activation [GO:0043030]; regulation of norepinephrine uptake [GO:0051621]; regulation of phospholipase activity [GO:0010517]; regulation of presynapse assembly [GO:1905606]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; regulation of synaptic vesicle recycling [GO:1903421]; regulation of transmembrane transporter activity [GO:0022898]; response to interleukin-1 [GO:0070555]; response to iron(II) ion [GO:0010040]; response to lipopolysaccharide [GO:0032496]; response to magnesium ion [GO:0032026]; response to type II interferon [GO:0034341]; response to xenobiotic stimulus [GO:0009410]; SNARE complex assembly [GO:0035493]; supramolecular fiber organization [GO:0097435]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle priming [GO:0016082]; synaptic vesicle transport [GO:0048489]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon terminus [GO:0043679]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth cone [GO:0030426]; inclusion body [GO:0016234]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; supramolecular fiber [GO:0099512]; synaptic vesicle membrane [GO:0030672]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; cuprous ion binding [GO:1903136]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; dynein complex binding [GO:0070840]; ferrous iron binding [GO:0008198]; histone binding [GO:0042393]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; lipid binding [GO:0008289]; magnesium ion binding [GO:0000287]; molecular adaptor activity [GO:0060090]; oxidoreductase activity [GO:0016491]; phospholipid binding [GO:0005543]; phosphoprotein binding [GO:0051219]; protein kinase inhibitor activity [GO:0004860]; SNARE binding [GO:0000149]; tau protein binding [GO:0048156]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon terminus [GO:0043679]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth cone [GO:0030426]; inclusion body [GO:0016234]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; supramolecular fiber [GO:0099512]; synaptic vesicle membrane [GO:0030672]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; cuprous ion binding [GO:1903136]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; dynein complex binding [GO:0070840]; ferrous iron binding [GO:0008198]; histone binding [GO:0042393]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; lipid binding [GO:0008289]; magnesium ion binding [GO:0000287]; molecular adaptor activity [GO:0060090]; oxidoreductase activity [GO:0016491]; phospholipid binding [GO:0005543]; phosphoprotein binding [GO:0051219]; protein kinase inhibitor activity [GO:0004860]; SNARE binding [GO:0000149]; tau protein binding [GO:0048156]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; adult locomotory behavior [GO:0008344]; amyloid fibril formation [GO:1990000]; cellular response to copper ion [GO:0071280]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to oxidative stress [GO:0034599]; chemical synaptic transmission [GO:0007268]; dopamine biosynthetic process [GO:0042416]; dopamine uptake involved in synaptic transmission [GO:0051583]; excitatory postsynaptic potential [GO:0060079]; fatty acid metabolic process [GO:0006631]; localization [GO:0051179]; long-term synaptic potentiation [GO:0060291]; microglial cell activation [GO:0001774]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial membrane organization [GO:0007006]; negative regulation of apoptotic process [GO:0043066]; negative regulation of chaperone-mediated autophagy [GO:1904715]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of dopamine uptake involved in synaptic transmission [GO:0051585]; negative regulation of exocytosis [GO:0045920]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902957]; negative regulation of monooxygenase activity [GO:0032769]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of norepinephrine uptake [GO:0051622]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of serotonin uptake [GO:0051612]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transporter activity [GO:0032410]; neuron apoptotic process [GO:0051402]; neutral lipid metabolic process [GO:0006638]; phospholipid metabolic process [GO:0006644]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endocytosis [GO:0045807]; positive regulation of exocytosis [GO:0045921]; positive regulation of glutathione peroxidase activity [GO:1903284]; positive regulation of hydrogen peroxide catabolic process [GO:1903285]; positive regulation of inflammatory response [GO:0050729]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of receptor recycling [GO:0001921]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of SNARE complex assembly [GO:0035543]; protein destabilization [GO:0031648]; protein tetramerization [GO:0051262]; receptor internalization [GO:0031623]; regulation of acyl-CoA biosynthetic process [GO:0050812]; regulation of dopamine secretion [GO:0014059]; regulation of glutamate secretion [GO:0014048]; regulation of locomotion [GO:0040012]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of macrophage activation [GO:0043030]; regulation of norepinephrine uptake [GO:0051621]; regulation of phospholipase activity [GO:0010517]; regulation of presynapse assembly [GO:1905606]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; regulation of synaptic vesicle recycling [GO:1903421]; regulation of transmembrane transporter activity [GO:0022898]; response to interleukin-1 [GO:0070555]; response to iron(II) ion [GO:0010040]; response to lipopolysaccharide [GO:0032496]; response to magnesium ion [GO:0032026]; response to type II interferon [GO:0034341]; response to xenobiotic stimulus [GO:0009410]; SNARE complex assembly [GO:0035493]; supramolecular fiber organization [GO:0097435]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle priming [GO:0016082]; synaptic vesicle transport [GO:0048489]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19762560, ECO:0000269|PubMed:24936070, ECO:0000269|PubMed:25561023, ECO:0000269|PubMed:26442590, ECO:0000269|PubMed:31034892}. Membrane {ECO:0000269|PubMed:24936070}. Nucleus {ECO:0000269|PubMed:12859192, ECO:0000269|PubMed:24936070}. Synapse {ECO:0000269|PubMed:15282274}. Secreted {ECO:0000269|PubMed:24936070}. Cell projection, axon {ECO:0000250|UniProtKB:O55042}. Note=Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:O55042, ECO:0000269|PubMed:15282274}.
P38117	reviewed	ETFB_HUMAN	Electron transfer flavoprotein subunit beta (Beta-ETF)	ETFB FP585	Homo sapiens (Human)	255	FUNCTION: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:25416781, PubMed:15159392, PubMed:15975918). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMP molecule that probably has a purely structural role (PubMed:8962055, PubMed:15159392, PubMed:15975918). {ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:25416781, ECO:0000269|PubMed:7912128, ECO:0000269|PubMed:8962055, ECO:0000303|PubMed:17941859, ECO:0000305}.		amino acid catabolic process [GO:0009063]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904]	electron transfer flavoprotein complex [GO:0045251]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	electron transfer activity [GO:0009055]	electron transfer flavoprotein complex [GO:0045251]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; electron transfer activity [GO:0009055]; amino acid catabolic process [GO:0009063]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:25023281, ECO:0000305|PubMed:8504797}.
P38159	reviewed	RBMX_HUMAN	RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]	RBMX HNRPG RBMXP1	Homo sapiens (Human)	391	FUNCTION: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}.		cellular response to interleukin-1 [GO:0071347]; membrane protein ectodomain proteolysis [GO:0006509]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; osteoblast differentiation [GO:0001649]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; transcription by RNA polymerase II [GO:0006366]	catalytic step 2 spliceosome [GO:0071013]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; supraspliceosomal complex [GO:0044530]	chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	catalytic step 2 spliceosome [GO:0071013]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; supraspliceosomal complex [GO:0044530]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cellular response to interleukin-1 [GO:0071347]; membrane protein ectodomain proteolysis [GO:0006509]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; osteoblast differentiation [GO:0001649]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus.
P38398	reviewed	BRCA1_HUMAN	Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)	BRCA1 RNF53	Homo sapiens (Human)	1863	FUNCTION: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:12887909, PubMed:10500182, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:12183412, PubMed:11836499, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative initiation at Met-18 of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: The N-terminus is confirmed by several cDNAs. {ECO:0000305}.	cellular response to indole-3-methanol [GO:0071681]; cellular response to ionizing radiation [GO:0071479]; cellular response to tumor necrosis factor [GO:0071356]; centrosome cycle [GO:0007098]; chordate embryonic development [GO:0043009]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; dosage compensation by inactivation of X chromosome [GO:0009048]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; fatty acid biosynthetic process [GO:0006633]; homologous recombination [GO:0035825]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; localization [GO:0051179]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of centriole replication [GO:0046600]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of histone acetylation [GO:0035067]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of histone acetylation [GO:0035066]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to ionizing radiation [GO:0010212]	BRCA1-A complex [GO:0070531]; BRCA1-B complex [GO:0070532]; BRCA1-BARD1 complex [GO:0031436]; BRCA1-C complex [GO:0070533]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; DNA repair complex [GO:1990391]; gamma-tubulin ring complex [GO:0000931]; intracellular non-membrane-bounded organelle [GO:0043232]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; ubiquitin ligase complex [GO:0000151]; XY body [GO:0001741]	damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; tubulin binding [GO:0015631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	BRCA1-A complex [GO:0070531]; BRCA1-B complex [GO:0070532]; BRCA1-BARD1 complex [GO:0031436]; BRCA1-C complex [GO:0070533]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; DNA repair complex [GO:1990391]; gamma-tubulin ring complex [GO:0000931]; intracellular non-membrane-bounded organelle [GO:0043232]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; ubiquitin ligase complex [GO:0000151]; XY body [GO:0001741]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; tubulin binding [GO:0015631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; cellular response to indole-3-methanol [GO:0071681]; cellular response to ionizing radiation [GO:0071479]; cellular response to tumor necrosis factor [GO:0071356]; centrosome cycle [GO:0007098]; chordate embryonic development [GO:0043009]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; dosage compensation by inactivation of X chromosome [GO:0009048]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; fatty acid biosynthetic process [GO:0006633]; homologous recombination [GO:0035825]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; localization [GO:0051179]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of centriole replication [GO:0046600]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of histone acetylation [GO:0035067]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of histone acetylation [GO:0035066]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15133502, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:26778126, ECO:0000269|PubMed:9528852}. Chromosome {ECO:0000269|PubMed:23269703, ECO:0000269|PubMed:25472942, ECO:0000269|PubMed:26778126}. Cytoplasm {ECO:0000269|PubMed:20160719}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719). {ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:26778126}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:8972225}.
P38405	reviewed	GNAL_HUMAN	Guanine nucleotide-binding protein G(olf) subunit alpha (Adenylate cyclase-stimulating G alpha protein, olfactory type)	GNAL	Homo sapiens (Human)	381	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; signal transduction [GO:0007165]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; signal transduction [GO:0007165]	
P38432	reviewed	COIL_HUMAN	Coilin (p80-coilin)	COIL CLN80	Homo sapiens (Human)	576	FUNCTION: Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}.		spliceosomal snRNP assembly [GO:0000387]	Cajal body [GO:0015030]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]	Cajal body [GO:0015030]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7679389}. Nucleus, Cajal body {ECO:0000269|PubMed:16079131, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:23726919, ECO:0000269|PubMed:7679389}.
P38435	reviewed	VKGC_HUMAN	Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase)	GGCX GC	Homo sapiens (Human)	758	FUNCTION: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide (PubMed:17073445). Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP) (PubMed:17073445). {ECO:0000269|PubMed:17073445}.	MISCELLANEOUS: The vitamin K-dependent protein substrates of carboxylase have usually a propeptide that binds to a high-affinity site on the carboxylase. CO(2), O(2) and reduced vitamin K are cosubstrates.	blood coagulation [GO:0007596]; protein modification process [GO:0036211]; vitamin K metabolic process [GO:0042373]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	gamma-glutamyl carboxylase activity [GO:0008488]; vitamin binding [GO:0019842]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; gamma-glutamyl carboxylase activity [GO:0008488]; vitamin binding [GO:0019842]; blood coagulation [GO:0007596]; protein modification process [GO:0036211]; vitamin K metabolic process [GO:0042373]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10910912}; Multi-pass membrane protein {ECO:0000269|PubMed:10910912}.
P38484	reviewed	INGR2_HUMAN	Interferon gamma receptor 2 (IFN-gamma receptor 2) (IFN-gamma-R2) (Interferon gamma receptor accessory factor 1) (AF-1) (Interferon gamma receptor beta-chain) (IFN-gamma-R-beta) (Interferon gamma transducer 1)	IFNGR2 IFNGT1	Homo sapiens (Human)	337	FUNCTION: Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114, PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114). {ECO:0000269|PubMed:15356148, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7673114, ECO:0000269|PubMed:8124716}.		cell surface receptor signaling pathway [GO:0007166]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; microglial cell activation [GO:0001774]; response to virus [GO:0009615]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196]	cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	cytokine receptor activity [GO:0004896]; type II interferon receptor activity [GO:0004906]	cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; cytokine receptor activity [GO:0004896]; type II interferon receptor activity [GO:0004906]; cell surface receptor signaling pathway [GO:0007166]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; microglial cell activation [GO:0001774]; response to virus [GO:0009615]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15356148, ECO:0000269|PubMed:15924140, ECO:0000269|PubMed:27599734}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10605012}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:23963039}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23963039}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:10605012}. Note=Has low cell surface expression and high cytoplasmic expression in T cells. The bias towards cytoplasmic expression may be due to ligand-independent receptor internalization and recycling. {ECO:0000269|PubMed:10605012, ECO:0000269|PubMed:15356148}.
P38567	reviewed	HYALP_HUMAN	Hyaluronidase PH-20 (Hyal-PH20) (EC 3.2.1.35) (Hyaluronoglucosaminidase PH-20) (Sperm adhesion molecule 1) (Sperm surface protein PH-20)	SPAM1 HYAL3 PH20	Homo sapiens (Human)	509	FUNCTION: Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. {ECO:0000269|PubMed:8282124}.		binding of sperm to zona pellucida [GO:0007339]; carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; hyaluronan catabolic process [GO:0030214]	acrosomal vesicle [GO:0001669]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	hyalurononglucosaminidase activity [GO:0004415]	acrosomal vesicle [GO:0001669]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; hyalurononglucosaminidase activity [GO:0004415]; binding of sperm to zona pellucida [GO:0007339]; carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; hyaluronan catabolic process [GO:0030214]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
P38570	reviewed	ITAE_HUMAN	Integrin alpha-E (HML-1 antigen) (Integrin alpha-IEL) (Mucosal lymphocyte 1 antigen) (CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]	ITGAE	Homo sapiens (Human)	1179	FUNCTION: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.		cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]	external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]; metal ion binding [GO:0046872]	external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P38571	reviewed	LICH_HUMAN	Lysosomal acid lipase/cholesteryl ester hydrolase (Acid cholesteryl ester hydrolase) (LAL) (EC 3.1.1.13) (Cholesteryl esterase) (Lipase A) (Sterol esterase)	LIPA	Homo sapiens (Human)	399	FUNCTION: Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. {ECO:0000269|PubMed:15269241, ECO:0000269|PubMed:1718995, ECO:0000269|PubMed:7204383, ECO:0000269|PubMed:8112342, ECO:0000269|PubMed:9633819}.		acute inflammatory response [GO:0002526]; adaptive thermogenesis [GO:1990845]; adipose tissue development [GO:0060612]; ATP biosynthetic process [GO:0006754]; blood vessel endothelial cell differentiation [GO:0060837]; bone marrow development [GO:0048539]; cell morphogenesis [GO:0000902]; cell proliferation in bone marrow [GO:0071838]; cellular lipid biosynthetic process [GO:0097384]; cholesterol biosynthetic process [GO:0006695]; cholesterol efflux [GO:0033344]; cholesterol storage [GO:0010878]; common myeloid progenitor cell proliferation [GO:0035726]; defecation [GO:0030421]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endothelial cell proliferation [GO:0001935]; fat cell proliferation [GO:0070341]; fatty acid metabolic process [GO:0006631]; gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; hematopoietic progenitor cell differentiation [GO:0002244]; homeostasis of number of cells within a tissue [GO:0048873]; lipid catabolic process [GO:0016042]; lipid homeostasis [GO:0055088]; lipid import into cell [GO:0140354]; lipoprotein catabolic process [GO:0042159]; liver morphogenesis [GO:0072576]; low-density lipoprotein particle clearance [GO:0034383]; lung development [GO:0030324]; lysosome organization [GO:0007040]; macrophage homeostasis [GO:0061519]; mitochondrion organization [GO:0007005]; mitotic cell cycle [GO:0000278]; multicellular organismal-level chemical homeostasis [GO:0140962]; myeloid cell apoptotic process [GO:0033028]; myeloid cell differentiation [GO:0030099]; positive regulation of T cell receptor signaling pathway [GO:0050862]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of mitochondrial membrane potential [GO:0051881]; respiratory burst involved in inflammatory response [GO:0002536]; response to cold [GO:0009409]; response to dietary excess [GO:0002021]; response to rapamycin [GO:1901355]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; small GTPase mediated signal transduction [GO:0007264]; spleen development [GO:0048536]; sterol metabolic process [GO:0016125]; T cell apoptotic process [GO:0070231]; T cell differentiation [GO:0030217]; T cell proliferation [GO:0042098]; tissue remodeling [GO:0048771]; TOR signaling [GO:0031929]; triglyceride metabolic process [GO:0006641]; triglyceride-rich lipoprotein particle clearance [GO:0071830]; vitamin A metabolic process [GO:0006776]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]	lipase activity [GO:0016298]; sterol esterase activity [GO:0004771]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; lipase activity [GO:0016298]; sterol esterase activity [GO:0004771]; acute inflammatory response [GO:0002526]; adaptive thermogenesis [GO:1990845]; adipose tissue development [GO:0060612]; ATP biosynthetic process [GO:0006754]; blood vessel endothelial cell differentiation [GO:0060837]; bone marrow development [GO:0048539]; cell morphogenesis [GO:0000902]; cell proliferation in bone marrow [GO:0071838]; cellular lipid biosynthetic process [GO:0097384]; cholesterol biosynthetic process [GO:0006695]; cholesterol efflux [GO:0033344]; cholesterol storage [GO:0010878]; common myeloid progenitor cell proliferation [GO:0035726]; defecation [GO:0030421]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endothelial cell proliferation [GO:0001935]; fat cell proliferation [GO:0070341]; fatty acid metabolic process [GO:0006631]; gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; hematopoietic progenitor cell differentiation [GO:0002244]; homeostasis of number of cells within a tissue [GO:0048873]; lipid catabolic process [GO:0016042]; lipid homeostasis [GO:0055088]; lipid import into cell [GO:0140354]; lipoprotein catabolic process [GO:0042159]; liver morphogenesis [GO:0072576]; low-density lipoprotein particle clearance [GO:0034383]; lung development [GO:0030324]; lysosome organization [GO:0007040]; macrophage homeostasis [GO:0061519]; mitochondrion organization [GO:0007005]; mitotic cell cycle [GO:0000278]; multicellular organismal-level chemical homeostasis [GO:0140962]; myeloid cell apoptotic process [GO:0033028]; myeloid cell differentiation [GO:0030099]; positive regulation of T cell receptor signaling pathway [GO:0050862]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of mitochondrial membrane potential [GO:0051881]; respiratory burst involved in inflammatory response [GO:0002536]; response to cold [GO:0009409]; response to dietary excess [GO:0002021]; response to rapamycin [GO:1901355]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; small GTPase mediated signal transduction [GO:0007264]; spleen development [GO:0048536]; sterol metabolic process [GO:0016125]; T cell apoptotic process [GO:0070231]; T cell differentiation [GO:0030217]; T cell proliferation [GO:0042098]; tissue remodeling [GO:0048771]; TOR signaling [GO:0031929]; triglyceride metabolic process [GO:0006641]; triglyceride-rich lipoprotein particle clearance [GO:0071830]; vitamin A metabolic process [GO:0006776]	SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q64194}.
P38606	reviewed	VATA_HUMAN	V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)	ATP6V1A ATP6A1 ATP6V1A1 VPP2	Homo sapiens (Human)	617	FUNCTION: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8463241). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857). {ECO:0000250|UniProtKB:P50516, ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:29668857, ECO:0000269|PubMed:8463241, ECO:0000303|PubMed:32001091}.; FUNCTION: (Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction. {ECO:0000269|PubMed:33208464}.		cellular response to increased oxygen levels [GO:0036295]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular iron ion homeostasis [GO:0006879]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase complex [GO:0033176]; secretory granule [GO:0030141]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase complex [GO:0033176]; secretory granule [GO:0030141]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; cellular response to increased oxygen levels [GO:0036295]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular iron ion homeostasis [GO:0006879]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29668857, ECO:0000269|PubMed:33208464}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P50516}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:23035048}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P31404}; Peripheral membrane protein {ECO:0000305}. Lysosome {ECO:0000250|UniProtKB:P50516}. Note=Co-localizes with WFS1 in the secretory granules in neuroblastoma cell lines. {ECO:0000269|PubMed:23035048}.
P38646	reviewed	GRP75_HUMAN	Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)	HSPA9 GRP75 HSPA9B mt-HSP70	Homo sapiens (Human)	679	FUNCTION: Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in the control of cell proliferation and cellular aging (By similarity). {ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:26702583}.		chaperone cofactor-dependent protein refolding [GO:0051085]; erythrocyte differentiation [GO:0030218]; inner mitochondrial membrane organization [GO:0007007]; intracellular protein transport [GO:0006886]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of apoptotic process [GO:0043066]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of hemopoiesis [GO:1903707]; protein export from nucleus [GO:0006611]; protein refolding [GO:0042026]; regulation of erythrocyte differentiation [GO:0045646]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; MIB complex [GO:0140275]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; SAM complex [GO:0001401]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; MIB complex [GO:0140275]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; SAM complex [GO:0001401]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; chaperone cofactor-dependent protein refolding [GO:0051085]; erythrocyte differentiation [GO:0030218]; inner mitochondrial membrane organization [GO:0007007]; intracellular protein transport [GO:0006886]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of apoptotic process [GO:0043066]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of hemopoiesis [GO:1903707]; protein export from nucleus [GO:0006611]; protein refolding [GO:0042026]; regulation of erythrocyte differentiation [GO:0045646]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:26702583}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106}.
P38919	reviewed	IF4A3_HUMAN	Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]	EIF4A3 DDX48 KIAA0111	Homo sapiens (Human)	411	FUNCTION: ATP-dependent RNA helicase (PubMed:16170325). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:16209946, PubMed:16170325, PubMed:16314458, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly (PubMed:22203037). Involved in craniofacial development (PubMed:24360810). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15034551, ECO:0000269|PubMed:16170325, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16314458, ECO:0000269|PubMed:16923391, ECO:0000269|PubMed:16931718, ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:19033377, ECO:0000269|PubMed:19409878, ECO:0000269|PubMed:20479275, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:24360810, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}.		associative learning [GO:0008306]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to selenite ion [GO:0072715]; embryonic cranial skeleton morphogenesis [GO:0048701]; exploration behavior [GO:0035640]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of selenocysteine incorporation [GO:1904570]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; response to organic cyclic compound [GO:0014070]; rRNA processing [GO:0006364]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; U2-type catalytic step 1 spliceosome [GO:0071006]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613]; selenocysteine insertion sequence binding [GO:0035368]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; U2-type catalytic step 1 spliceosome [GO:0071006]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613]; selenocysteine insertion sequence binding [GO:0035368]; associative learning [GO:0008306]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to selenite ion [GO:0072715]; embryonic cranial skeleton morphogenesis [GO:0048701]; exploration behavior [GO:0035640]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of selenocysteine incorporation [GO:1904570]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; response to organic cyclic compound [GO:0014070]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10623621, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. Nucleus speckle {ECO:0000269|PubMed:10623621}. Cytoplasm {ECO:0000250|UniProtKB:Q3B8Q2}. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By similarity). {ECO:0000250|UniProtKB:Q3B8Q2}.
P38935	reviewed	SMBP2_HUMAN	DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2)	IGHMBP2 SMBP2 SMUBP2	Homo sapiens (Human)	993	FUNCTION: 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:19158098, PubMed:30218034, PubMed:22999958). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:8349627, PubMed:22999958). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19299493, PubMed:19158098). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493). {ECO:0000250|UniProtKB:Q9EQN5, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493, ECO:0000269|PubMed:22999958, ECO:0000269|PubMed:30218034, ECO:0000269|PubMed:8349627}.		DNA duplex unwinding [GO:0032508]; RNA secondary structure unwinding [GO:0010501]	axon [GO:0030424]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	5'-3' DNA helicase activity [GO:0043139]; 5'-3' RNA helicase activity [GO:0032574]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent activity, acting on RNA [GO:0008186]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; identical protein binding [GO:0042802]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; transcription factor binding [GO:0008134]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]	axon [GO:0030424]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; 5'-3' DNA helicase activity [GO:0043139]; 5'-3' RNA helicase activity [GO:0032574]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent activity, acting on RNA [GO:0008186]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; identical protein binding [GO:0042802]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; transcription factor binding [GO:0008134]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; DNA duplex unwinding [GO:0032508]; RNA secondary structure unwinding [GO:0010501]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19299493}. Cytoplasm {ECO:0000269|PubMed:19299493}. Cell projection, axon {ECO:0000250|UniProtKB:P40694}.
P38936	reviewed	CDN1A_HUMAN	Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)	CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1	Homo sapiens (Human)	164	FUNCTION: Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}.		animal organ regeneration [GO:0031100]; cellular response to amino acid starvation [GO:0034198]; cellular response to extracellular stimulus [GO:0031668]; cellular response to gamma radiation [GO:0071480]; cellular response to heat [GO:0034605]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV-B [GO:0071493]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; G1/S transition of mitotic cell cycle [GO:0000082]; heart development [GO:0007507]; intestinal epithelial cell maturation [GO:0060574]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle tissue regeneration [GO:1905179]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein kinase activity [GO:1904030]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of phosphorylation [GO:0042326]; negative regulation of protein binding [GO:0032091]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; oncogene-induced cell senescence [GO:0090402]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein import into nucleus [GO:0006606]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; replicative senescence [GO:0090399]; response to aldosterone [GO:1904044]; response to arsenic-containing substance [GO:0046685]; response to corticosterone [GO:0051412]; response to hyperoxia [GO:0055093]; response to organonitrogen compound [GO:0010243]; response to toxic substance [GO:0009636]; response to X-ray [GO:0010165]; response to xenobiotic stimulus [GO:0009410]; stress-induced premature senescence [GO:0090400]; tissue regeneration [GO:0042246]; wound healing [GO:0042060]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCNA-p21 complex [GO:0070557]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	cyclin binding [GO:0030332]; cyclin-dependent protein kinase activating kinase activity [GO:0019912]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; molecular function inhibitor activity [GO:0140678]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCNA-p21 complex [GO:0070557]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; cyclin binding [GO:0030332]; cyclin-dependent protein kinase activating kinase activity [GO:0019912]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; molecular function inhibitor activity [GO:0140678]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; animal organ regeneration [GO:0031100]; cellular response to amino acid starvation [GO:0034198]; cellular response to extracellular stimulus [GO:0031668]; cellular response to gamma radiation [GO:0071480]; cellular response to heat [GO:0034605]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV-B [GO:0071493]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; G1/S transition of mitotic cell cycle [GO:0000082]; heart development [GO:0007507]; intestinal epithelial cell maturation [GO:0060574]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle tissue regeneration [GO:1905179]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein kinase activity [GO:1904030]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of phosphorylation [GO:0042326]; negative regulation of protein binding [GO:0032091]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; oncogene-induced cell senescence [GO:0090402]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein import into nucleus [GO:0006606]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; replicative senescence [GO:0090399]; response to aldosterone [GO:1904044]; response to arsenic-containing substance [GO:0046685]; response to corticosterone [GO:0051412]; response to hyperoxia [GO:0055093]; response to organonitrogen compound [GO:0010243]; response to toxic substance [GO:0009636]; response to X-ray [GO:0010165]; response to xenobiotic stimulus [GO:0009410]; stress-induced premature senescence [GO:0090400]; tissue regeneration [GO:0042246]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11463845}. Nucleus {ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:23213251}.
P39019	reviewed	RS19_HUMAN	Small ribosomal subunit protein eS19 (40S ribosomal protein S19)	RPS19	Homo sapiens (Human)	145	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:16990592, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-negative bacterium [GO:0050829]; erythrocyte differentiation [GO:0030218]; killing of cells of another organism [GO:0031640]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; monocyte chemotaxis [GO:0002548]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; nucleolus organization [GO:0007000]; positive regulation of respiratory burst involved in inflammatory response [GO:0060265]; response to extracellular stimulus [GO:0009991]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]	fibroblast growth factor binding [GO:0017134]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; fibroblast growth factor binding [GO:0017134]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-negative bacterium [GO:0050829]; erythrocyte differentiation [GO:0030218]; killing of cells of another organism [GO:0031640]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; monocyte chemotaxis [GO:0002548]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; nucleolus organization [GO:0007000]; positive regulation of respiratory burst involved in inflammatory response [GO:0060265]; response to extracellular stimulus [GO:0009991]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:12586610, ECO:0000269|PubMed:17517689, ECO:0000269|PubMed:34516797}.
P39023	reviewed	RL3_HUMAN	Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B)	RPL3 OK/SW-cl.32	Homo sapiens (Human)	403	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547, PubMed:35674491). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.		cellular response to interleukin-4 [GO:0071353]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular response to interleukin-4 [GO:0071353]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16963496}. Cytoplasm {ECO:0000269|PubMed:16963496, ECO:0000269|PubMed:23636399}.
P39059	reviewed	COFA1_HUMAN	Collagen alpha-1(XV) chain [Cleaved into: Restin (Endostatin-XV) (Related to endostatin) (Restin-I); Restin-2 (Restin-II); Restin-3 (Restin-III); Restin-4 (Restin-IV)]	COL15A1	Homo sapiens (Human)	1388	FUNCTION: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. {ECO:0000269|PubMed:10049780}.; FUNCTION: Restin potently inhibits angiogenesis. {ECO:0000250}.		angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; signal transduction [GO:0007165]	basement membrane [GO:0005604]; collagen type XV trimer [GO:0005582]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	basement membrane [GO:0005604]; collagen type XV trimer [GO:0005582]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313}.
P39060	reviewed	COIA1_HUMAN	Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)]	COL18A1	Homo sapiens (Human)	1754	FUNCTION: Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. {ECO:0000269|PubMed:10942434}.; FUNCTION: [Non-collagenous domain 1]: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling. {ECO:0000269|PubMed:11257123}.; FUNCTION: [Endostatin]: Potently inhibits endothelial cell proliferation and angiogenesis (PubMed:9459295). May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123). {ECO:0000250|UniProtKB:P39061, ECO:0000269|PubMed:11257123, ECO:0000269|PubMed:9459295}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000305}.	angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; endothelial cell morphogenesis [GO:0001886]; negative regulation of cell population proliferation [GO:0008285]; notochord development [GO:0030903]; response to hydrostatic pressure [GO:0051599]; response to xenobiotic stimulus [GO:0009410]; skeletal system development [GO:0001501]; visual perception [GO:0007601]	basement membrane [GO:0005604]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]	basement membrane [GO:0005604]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; endothelial cell morphogenesis [GO:0001886]; negative regulation of cell population proliferation [GO:0008285]; notochord development [GO:0030903]; response to hydrostatic pressure [GO:0051599]; response to xenobiotic stimulus [GO:0009410]; skeletal system development [GO:0001501]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:P39061}.; SUBCELLULAR LOCATION: [Non-collagenous domain 1]: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:P39061}. Secreted {ECO:0000250|UniProtKB:P39061}.; SUBCELLULAR LOCATION: [Endostatin]: Secreted {ECO:0000269|PubMed:10441114}. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000305}.
P39086	reviewed	GRIK1_HUMAN	Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5)	GRIK1 GLUR5	Homo sapiens (Human)	918	FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.	MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > L-glutamate = quisqualate > CNQX = DNQX > AMPA > dihydrokainate > NMDA.	central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; nervous system development [GO:0007399]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic transmission, glutamatergic [GO:0035249]	intracellular membrane-bounded organelle [GO:0043231]; kainate selective glutamate receptor complex [GO:0032983]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]	kainate selective glutamate receptor activity [GO:0015277]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	intracellular membrane-bounded organelle [GO:0043231]; kainate selective glutamate receptor complex [GO:0032983]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; kainate selective glutamate receptor activity [GO:0015277]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; nervous system development [GO:0007399]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
P39210	reviewed	MPV17_HUMAN	Protein Mpv17	MPV17	Homo sapiens (Human)	176	FUNCTION: Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (PubMed:25861990). Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (PubMed:26760297). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity). {ECO:0000250|UniProtKB:P19258, ECO:0000269|PubMed:25861990, ECO:0000269|PubMed:26760297}.		cellular response to reactive oxygen species [GO:0034614]; glomerular basement membrane development [GO:0032836]; homeostatic process [GO:0042592]; inner ear development [GO:0048839]; mitochondrial genome maintenance [GO:0000002]; regulation of mitochondrial DNA metabolic process [GO:1901858]; regulation of reactive oxygen species metabolic process [GO:2000377]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	channel activity [GO:0015267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; channel activity [GO:0015267]; cellular response to reactive oxygen species [GO:0034614]; glomerular basement membrane development [GO:0032836]; homeostatic process [GO:0042592]; inner ear development [GO:0048839]; mitochondrial genome maintenance [GO:0000002]; regulation of mitochondrial DNA metabolic process [GO:1901858]; regulation of reactive oxygen species metabolic process [GO:2000377]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16582907, ECO:0000269|PubMed:16582910}; Multi-pass membrane protein {ECO:0000269|PubMed:16582907, ECO:0000269|PubMed:16582910}.
P39656	reviewed	OST48_HUMAN	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit)	DDOST KIAA0115 OST48 OK/SW-cl.45	Homo sapiens (Human)	456	FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (PubMed:22467853). {ECO:0000250|UniProtKB:Q05052, ECO:0000269|PubMed:22467853, ECO:0000269|PubMed:31831667}.		protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; regulation of protein stability [GO:0031647]; response to cytokine [GO:0034097]; T cell activation [GO:0042110]	azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]	enzyme activator activity [GO:0008047]	azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]; enzyme activator activity [GO:0008047]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; regulation of protein stability [GO:0031647]; response to cytokine [GO:0034097]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q29381}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q29381}.
P39687	reviewed	AN32A_HUMAN	Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI)	ANP32A C15orf1 LANP MAPM PHAP1	Homo sapiens (Human)	249	FUNCTION: Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:16341127, PubMed:11360199, PubMed:18439902, PubMed:10400610). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:32694517, PubMed:33045004, PubMed:33208942, PubMed:30666459). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}.		intracellular signal transduction [GO:0035556]; nucleocytoplasmic transport [GO:0006913]; regulation of apoptotic process [GO:0042981]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	histone binding [GO:0042393]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; histone binding [GO:0042393]; RNA binding [GO:0003723]; intracellular signal transduction [GO:0035556]; nucleocytoplasmic transport [GO:0006913]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:18180367}. Cytoplasm {ECO:0000269|PubMed:18180367}. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm. {ECO:0000250, ECO:0000269|PubMed:18180367}.
P39748	reviewed	FEN1_HUMAN	Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1)	FEN1 RAD2	Homo sapiens (Human)	380	FUNCTION: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}.	MISCELLANEOUS: [Isoform FENMIT]: No nuclease activity. Binds preferentially to RNA flap structures and R-loops. {ECO:0000305}.	base-excision repair, gap-filling [GO:0006287]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication, removal of RNA primer [GO:0043137]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; memory [GO:0007613]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of sister chromatid cohesion [GO:0045876]; telomere maintenance via semi-conservative replication [GO:0032201]; UV protection [GO:0009650]	chromosome, telomeric region [GO:0000781]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; double-stranded DNA exodeoxyribonuclease activity [GO:0008309]; endonuclease activity [GO:0004519]; exonuclease activity [GO:0004527]; flap endonuclease activity [GO:0048256]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; RNA-DNA hybrid ribonuclease activity [GO:0004523]	chromosome, telomeric region [GO:0000781]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; 5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; double-stranded DNA exodeoxyribonuclease activity [GO:0008309]; endonuclease activity [GO:0004519]; exonuclease activity [GO:0004527]; flap endonuclease activity [GO:0048256]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; base-excision repair, gap-filling [GO:0006287]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication, removal of RNA primer [GO:0043137]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; memory [GO:0007613]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of sister chromatid cohesion [GO:0045876]; telomere maintenance via semi-conservative replication [GO:0032201]; UV protection [GO:0009650]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.; SUBCELLULAR LOCATION: [Isoform FENMIT]: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:23675412}.
P39877	reviewed	PA2G5_HUMAN	Phospholipase A2 group V (EC 3.1.1.4) (PLA2-10) (Phosphatidylcholine 2-acylhydrolase 5)	PLA2G5	Homo sapiens (Human)	138	FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:8300559). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (PubMed:8300559, PubMed:14998370, PubMed:23533611). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes (PubMed:23533611). Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines (PubMed:25725101). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells (PubMed:12124392, PubMed:12796497). In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way (PubMed:12796497). In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (PubMed:12124392). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (By similarity). May regulate antigen processing in antigen-presenting cells (By similarity). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370). {ECO:0000250|UniProtKB:P97391, ECO:0000269|PubMed:11694541, ECO:0000269|PubMed:12124392, ECO:0000269|PubMed:12796497, ECO:0000269|PubMed:14998370, ECO:0000269|PubMed:23533611, ECO:0000269|PubMed:25725101, ECO:0000269|PubMed:8300559}.		arachidonic acid secretion [GO:0050482]; cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid metabolic process [GO:0006631]; leukotriene biosynthetic process [GO:0019370]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of T cell proliferation [GO:0042130]; phagosome-lysosome fusion [GO:0090385]; phosphatidylcholine catabolic process [GO:0034638]; phospholipid metabolic process [GO:0006644]; positive regulation of antifungal innate immune response [GO:1905036]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immune complex clearance by monocytes and macrophages [GO:0090265]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of opsonization [GO:1903028]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phagosome maturation [GO:1905164]; positive regulation of phospholipase activity [GO:0010518]	early phagosome [GO:0032009]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipid binding [GO:0005543]	early phagosome [GO:0032009]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipid binding [GO:0005543]; arachidonic acid secretion [GO:0050482]; cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid metabolic process [GO:0006631]; leukotriene biosynthetic process [GO:0019370]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of T cell proliferation [GO:0042130]; phagosome-lysosome fusion [GO:0090385]; phosphatidylcholine catabolic process [GO:0034638]; phospholipid metabolic process [GO:0006644]; positive regulation of antifungal innate immune response [GO:1905036]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immune complex clearance by monocytes and macrophages [GO:0090265]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of opsonization [GO:1903028]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phagosome maturation [GO:1905164]; positive regulation of phospholipase activity [GO:0010518]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8300559}. Cell membrane {ECO:0000250|UniProtKB:P97391}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P97391}. Recycling endosome {ECO:0000250|UniProtKB:P97391}. Golgi apparatus, cis-Golgi network {ECO:0000250|UniProtKB:P97391}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P97391}.
P39880	reviewed	CUX1_HUMAN	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110]	CUX1 CUTL1	Homo sapiens (Human)	1505	FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.	MISCELLANEOUS: Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.	negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of dendrite morphogenesis [GO:0050775]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of dendrite morphogenesis [GO:0050775]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15099520}.
P39900	reviewed	MMP12_HUMAN	Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)	MMP12 HME	Homo sapiens (Human)	470	FUNCTION: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.		bronchiole development [GO:0060435]; cellular response to virus [GO:0098586]; collagen catabolic process [GO:0030574]; elastin catabolic process [GO:0060309]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; lung alveolus development [GO:0048286]; negative regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904905]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein import into nucleus [GO:0006606]; proteolysis [GO:0006508]; regulation of defense response to virus by host [GO:0050691]; response to amyloid-beta [GO:1904645]; wound healing, spreading of epidermal cells [GO:0035313]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; core promoter sequence-specific DNA binding [GO:0001046]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; core promoter sequence-specific DNA binding [GO:0001046]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; bronchiole development [GO:0060435]; cellular response to virus [GO:0098586]; collagen catabolic process [GO:0030574]; elastin catabolic process [GO:0060309]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; lung alveolus development [GO:0048286]; negative regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904905]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein import into nucleus [GO:0006606]; proteolysis [GO:0006508]; regulation of defense response to virus by host [GO:0050691]; response to amyloid-beta [GO:1904645]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
P39905	reviewed	GDNF_HUMAN	Glial cell line-derived neurotrophic factor (hGDNF) (Astrocyte-derived trophic factor) (ATF)	GDNF	Homo sapiens (Human)	211	FUNCTION: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. {ECO:0000269|PubMed:8493557}.		adult locomotory behavior [GO:0008344]; branching involved in ureteric bud morphogenesis [GO:0001658]; commissural neuron axon guidance [GO:0071679]; dorsal spinal cord development [GO:0021516]; embryonic organ development [GO:0048568]; enteric nervous system development [GO:0048484]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; metanephros development [GO:0001656]; mRNA stabilization [GO:0048255]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neuron projection development [GO:0031175]; organ induction [GO:0001759]; peripheral nervous system development [GO:0007422]; peristalsis [GO:0030432]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of monooxygenase activity [GO:0032770]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureteric bud formation [GO:0072107]; postganglionic parasympathetic fiber development [GO:0021784]; postsynaptic membrane organization [GO:0001941]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of gene expression [GO:0010468]; regulation of morphogenesis of a branching structure [GO:0060688]; regulation of semaphorin-plexin signaling pathway [GO:2001260]; regulation of stem cell differentiation [GO:2000736]; signal transduction [GO:0007165]; sympathetic nervous system development [GO:0048485]; ureteric bud formation [GO:0060676]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]	chemoattractant activity involved in axon guidance [GO:1902379]; glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; chemoattractant activity involved in axon guidance [GO:1902379]; glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; adult locomotory behavior [GO:0008344]; branching involved in ureteric bud morphogenesis [GO:0001658]; commissural neuron axon guidance [GO:0071679]; dorsal spinal cord development [GO:0021516]; embryonic organ development [GO:0048568]; enteric nervous system development [GO:0048484]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; metanephros development [GO:0001656]; mRNA stabilization [GO:0048255]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neuron projection development [GO:0031175]; organ induction [GO:0001759]; peripheral nervous system development [GO:0007422]; peristalsis [GO:0030432]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of monooxygenase activity [GO:0032770]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureteric bud formation [GO:0072107]; postganglionic parasympathetic fiber development [GO:0021784]; postsynaptic membrane organization [GO:0001941]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of gene expression [GO:0010468]; regulation of morphogenesis of a branching structure [GO:0060688]; regulation of semaphorin-plexin signaling pathway [GO:2001260]; regulation of stem cell differentiation [GO:2000736]; signal transduction [GO:0007165]; sympathetic nervous system development [GO:0048485]; ureteric bud formation [GO:0060676]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:9811930}.
P40121	reviewed	CAPG_HUMAN	Macrophage-capping protein (Actin regulatory protein CAP-G)	CAPG AFCP MCP	Homo sapiens (Human)	348	FUNCTION: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.		actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; protein-containing complex assembly [GO:0065003]	actin cytoskeleton [GO:0015629]; centriole [GO:0005814]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; Flemming body [GO:0090543]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]	actin cytoskeleton [GO:0015629]; centriole [GO:0005814]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; Flemming body [GO:0090543]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18266911}. Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P24452}. Cell projection, ruffle {ECO:0000250|UniProtKB:P24452}. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia. {ECO:0000250|UniProtKB:P24452}.
P40123	reviewed	CAP2_HUMAN	Adenylyl cyclase-associated protein 2 (CAP 2)	CAP2	Homo sapiens (Human)	477	FUNCTION: May have a regulatory bifunctional role.		actin filament organization [GO:0007015]; activation of adenylate cyclase activity [GO:0007190]; cAMP-mediated signaling [GO:0019933]; cell morphogenesis [GO:0000902]; establishment or maintenance of cell polarity [GO:0007163]; presynaptic actin cytoskeleton organization [GO:0099140]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	actin binding [GO:0003779]; adenylate cyclase binding [GO:0008179]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; actin binding [GO:0003779]; adenylate cyclase binding [GO:0008179]; identical protein binding [GO:0042802]; actin filament organization [GO:0007015]; activation of adenylate cyclase activity [GO:0007190]; cAMP-mediated signaling [GO:0019933]; cell morphogenesis [GO:0000902]; establishment or maintenance of cell polarity [GO:0007163]; presynaptic actin cytoskeleton organization [GO:0099140]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
P40126	reviewed	TYRP2_HUMAN	L-dopachrome tautomerase (DCT) (DT) (EC 5.3.3.12) (L-dopachrome Delta-isomerase) (Tyrosinase-related protein 2) (TRP-2) (TRP2)	DCT TYRP2	Homo sapiens (Human)	519	FUNCTION: Plays a role in melanin biosynthesis (PubMed:33100333). Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). {ECO:0000269|PubMed:33100333, ECO:0000269|PubMed:8306979}.		cell development [GO:0048468]; developmental pigmentation [GO:0048066]; epidermis development [GO:0008544]; melanin biosynthetic process from tyrosine [GO:0006583]; positive regulation of neuroblast proliferation [GO:0002052]; response to blue light [GO:0009637]; ventricular zone neuroblast division [GO:0021847]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886]	copper ion binding [GO:0005507]; dopachrome isomerase activity [GO:0004167]; oxidoreductase activity [GO:0016491]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886]; copper ion binding [GO:0005507]; dopachrome isomerase activity [GO:0004167]; oxidoreductase activity [GO:0016491]; cell development [GO:0048468]; developmental pigmentation [GO:0048066]; epidermis development [GO:0008544]; melanin biosynthetic process from tyrosine [GO:0006583]; positive regulation of neuroblast proliferation [GO:0002052]; response to blue light [GO:0009637]; ventricular zone neuroblast division [GO:0021847]	SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000250|UniProtKB:P29812}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250|UniProtKB:P29812}.
P40145	reviewed	ADCY8_HUMAN	Adenylate cyclase type 8 (EC 4.6.1.1) (ATP pyrophosphate-lyase 8) (Adenylate cyclase type VIII) (Adenylyl cyclase 8) (AC8) (Ca(2+)/calmodulin-activated adenylyl cyclase)	ADCY8	Homo sapiens (Human)	1251	FUNCTION: Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells. {ECO:0000250|UniProtKB:P40146}.		activation of protein kinase A activity [GO:0034199]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; cellular response to calcium ion [GO:0071277]; cellular response to forskolin [GO:1904322]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to morphine [GO:0071315]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; glucose homeostasis [GO:0042593]; glucose mediated signaling pathway [GO:0010255]; intracellular signal transduction [GO:0035556]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; memory [GO:0007613]; neuroinflammatory response [GO:0150076]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synaptic plasticity [GO:0031915]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260]; regulation of cellular response to stress [GO:0080135]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of insulin secretion [GO:0050796]; signal transduction [GO:0007165]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; dendrite [GO:0030425]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]	actin binding [GO:0003779]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; dendrite [GO:0030425]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; actin binding [GO:0003779]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; activation of protein kinase A activity [GO:0034199]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; cellular response to calcium ion [GO:0071277]; cellular response to forskolin [GO:1904322]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to morphine [GO:0071315]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; glucose homeostasis [GO:0042593]; glucose mediated signaling pathway [GO:0010255]; intracellular signal transduction [GO:0035556]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; memory [GO:0007613]; neuroinflammatory response [GO:0150076]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synaptic plasticity [GO:0031915]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260]; regulation of cellular response to stress [GO:0080135]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of insulin secretion [GO:0050796]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P97490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97490}. Basolateral cell membrane {ECO:0000250|UniProtKB:P97490}. Apical cell membrane {ECO:0000250|UniProtKB:P97490}. Synapse {ECO:0000250|UniProtKB:P97490}. Cell projection, dendrite {ECO:0000250|UniProtKB:P97490}. Cell projection, axon {ECO:0000250|UniProtKB:P97490}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P97490}. Postsynaptic density {ECO:0000250|UniProtKB:P97490}. Membrane raft {ECO:0000250|UniProtKB:P40146}. Membrane, coated pit {ECO:0000250|UniProtKB:P40146}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P40146}. Membrane, caveola {ECO:0000250|UniProtKB:P40146}. Note=Localized to dendritic arbors (By similarity). Monomeric N-glycosylated species localizes in membrane raft. In contrast, monomeric unglycosylated forms are enriched in clathrin-coated pits and vesicles. Dimers are also localized outside of membrane rafts. Membrane raft localization and integrity is indispensable for CCE-stimulated adenylate cyclase activity (By similarity). {ECO:0000250|UniProtKB:P40146, ECO:0000250|UniProtKB:P97490}.
P40189	reviewed	IL6RB_HUMAN	Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)	IL6ST	Homo sapiens (Human)	918	FUNCTION: Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:2261637, PubMed:19915009, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR (PubMed:19386761). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). {ECO:0000250|UniProtKB:Q00560, ECO:0000269|PubMed:19386761, ECO:0000269|PubMed:19915009, ECO:0000269|PubMed:2261637, ECO:0000269|PubMed:23294003, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:28747427, ECO:0000269|PubMed:30309848}.; FUNCTION: [Isoform 2]: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response (PubMed:11121117, PubMed:21990364, PubMed:30279168). Also blocks IL11 cluster signaling through IL11R (PubMed:30279168). {ECO:0000269|PubMed:11121117, ECO:0000269|PubMed:21990364, ECO:0000269|PubMed:30279168}.		ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; glycogen metabolic process [GO:0005977]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; leukemia inhibitory factor signaling pathway [GO:0048861]; negative regulation of apoptotic process [GO:0043066]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; negative regulation of neuron apoptotic process [GO:0043524]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular endothelial growth factor production [GO:0010575]; response to cytokine [GO:0034097]; T-helper 17 cell lineage commitment [GO:0072540]	ciliary neurotrophic factor receptor complex [GO:0070110]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; oncostatin-M receptor complex [GO:0005900]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ciliary neurotrophic factor receptor activity [GO:0004897]; ciliary neurotrophic factor receptor binding [GO:0005127]; coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-11 binding [GO:0019970]; interleukin-11 receptor activity [GO:0004921]; interleukin-27 receptor activity [GO:0045509]; protein tyrosine kinase activator activity [GO:0030296]; scaffold protein binding [GO:0097110]	ciliary neurotrophic factor receptor complex [GO:0070110]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; oncostatin-M receptor complex [GO:0005900]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ciliary neurotrophic factor receptor activity [GO:0004897]; ciliary neurotrophic factor receptor binding [GO:0005127]; coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-11 binding [GO:0019970]; interleukin-11 receptor activity [GO:0004921]; interleukin-27 receptor activity [GO:0045509]; protein tyrosine kinase activator activity [GO:0030296]; scaffold protein binding [GO:0097110]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; glycogen metabolic process [GO:0005977]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; leukemia inhibitory factor signaling pathway [GO:0048861]; negative regulation of apoptotic process [GO:0043066]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; negative regulation of neuron apoptotic process [GO:0043524]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular endothelial growth factor production [GO:0010575]; response to cytokine [GO:0034097]; T-helper 17 cell lineage commitment [GO:0072540]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:19915009}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:24629561}.
P40197	reviewed	GPV_HUMAN	Platelet glycoprotein V (GPV) (Glycoprotein 5) (CD antigen CD42d)	GP5	Homo sapiens (Human)	560	FUNCTION: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.		blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; megakaryocyte development [GO:0035855]; positive regulation of platelet activation [GO:0010572]; release of sequestered calcium ion into cytosol [GO:0051209]	extracellular exosome [GO:0070062]; glycoprotein Ib-IX-V complex [GO:1990779]; plasma membrane [GO:0005886]		extracellular exosome [GO:0070062]; glycoprotein Ib-IX-V complex [GO:1990779]; plasma membrane [GO:0005886]; blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; megakaryocyte development [GO:0035855]; positive regulation of platelet activation [GO:0010572]; release of sequestered calcium ion into cytosol [GO:0051209]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P40198	reviewed	CEAM3_HUMAN	Carcinoembryonic antigen-related cell adhesion molecule 3 (Carcinoembryonic antigen CGM1) (CD antigen CD66d)	CEACAM3 CD66D CGM1	Homo sapiens (Human)	252	FUNCTION: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. {ECO:0000269|PubMed:12864848, ECO:0000269|PubMed:14707113}.		regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	protein tyrosine kinase binding [GO:1990782]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; protein tyrosine kinase binding [GO:1990782]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P40199	reviewed	CEAM6_HUMAN	Carcinoembryonic antigen-related cell adhesion molecule 6 (Non-specific crossreacting antigen) (Normal cross-reacting antigen) (CD antigen CD66c)	CEACAM6 NCA	Homo sapiens (Human)	344	FUNCTION: Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051). Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575). {ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:11590190, ECO:0000269|PubMed:1378450, ECO:0000269|PubMed:14724575, ECO:0000269|PubMed:16204051, ECO:0000269|PubMed:2022629, ECO:0000269|PubMed:2803308, ECO:0000269|PubMed:8776764}.		apoptotic process [GO:0006915]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of anoikis [GO:2000811]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; signal transduction [GO:0007165]	apical plasma membrane [GO:0016324]; azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]	apical plasma membrane [GO:0016324]; azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; apoptotic process [GO:0006915]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of anoikis [GO:2000811]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2317824}. Apical cell membrane {ECO:0000269|PubMed:10436421}. Cell surface {ECO:0000269|PubMed:1378450, ECO:0000269|PubMed:16204051, ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:8776764, ECO:0000305|PubMed:2803308}. Note=Localized to the apical glycocalyx surface. {ECO:0000269|PubMed:10436421}.
P40200	reviewed	TACT_HUMAN	T-cell surface protein tactile (Cell surface antigen CD96) (T cell-activated increased late expression protein) (CD antigen CD96)	CD96	Homo sapiens (Human)	585	FUNCTION: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.		cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of natural killer cell cytokine production [GO:0002728]; negative regulation of type II interferon production [GO:0032689]; response to lipopolysaccharide [GO:0032496]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of natural killer cell cytokine production [GO:0002728]; negative regulation of type II interferon production [GO:0032689]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P40222	reviewed	TXLNA_HUMAN	Alpha-taxilin	TXLNA TXLN	Homo sapiens (Human)	546	FUNCTION: May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.		B cell activation [GO:0042113]; exocytosis [GO:0006887]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]	syntaxin binding [GO:0019905]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; syntaxin binding [GO:0019905]; B cell activation [GO:0042113]; exocytosis [GO:0006887]	
P40225	reviewed	TPO_HUMAN	Thrombopoietin (C-mpl ligand) (ML) (Megakaryocyte colony-stimulating factor) (Megakaryocyte growth and development factor) (MGDF) (Myeloproliferative leukemia virus oncogene ligand)	THPO MGDF	Homo sapiens (Human)	353	FUNCTION: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.		cell population proliferation [GO:0008283]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; receptor signaling pathway via STAT [GO:0097696]; thrombopoietin-mediated signaling pathway [GO:0038163]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; cell population proliferation [GO:0008283]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; receptor signaling pathway via STAT [GO:0097696]; thrombopoietin-mediated signaling pathway [GO:0038163]	SUBCELLULAR LOCATION: Secreted.
P40227	reviewed	TCPZ_HUMAN	T-complex protein 1 subunit zeta (TCP-1-zeta) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (HTR3) (Tcp20)	CCT6A CCT6 CCTZ	Homo sapiens (Human)	531	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:25467444, ECO:0000305}.		chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; WD40-repeat domain binding [GO:0071987]	chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; WD40-repeat domain binding [GO:0071987]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8034610}.
P40238	reviewed	TPOR_HUMAN	Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110)	MPL TPOR	Homo sapiens (Human)	635	FUNCTION: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. {ECO:0000250|UniProtKB:Q08351}.		basophil homeostasis [GO:1990960]; cellular response to hypoxia [GO:0071456]; eosinophil homeostasis [GO:1990959]; immunoglobulin mediated immune response [GO:0016064]; monocyte homeostasis [GO:0035702]; neutrophil homeostasis [GO:0001780]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of platelet formation [GO:1905221]; thrombopoietin-mediated signaling pathway [GO:0038163]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	thrombopoietin receptor activity [GO:0038164]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; thrombopoietin receptor activity [GO:0038164]; basophil homeostasis [GO:1990960]; cellular response to hypoxia [GO:0071456]; eosinophil homeostasis [GO:1990959]; immunoglobulin mediated immune response [GO:0016064]; monocyte homeostasis [GO:0035702]; neutrophil homeostasis [GO:0001780]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of platelet formation [GO:1905221]; thrombopoietin-mediated signaling pathway [GO:0038163]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25538044}; Single-pass type I membrane protein. Golgi apparatus {ECO:0000269|PubMed:25538044}. Cell surface {ECO:0000269|PubMed:25538044}.
P40259	reviewed	CD79B_HUMAN	B-cell antigen receptor complex-associated protein beta chain (B-cell-specific glycoprotein B29) (Ig-beta) (Immunoglobulin-associated B29 protein) (CD antigen CD79b)	CD79B B29 IGB	Homo sapiens (Human)	229	FUNCTION: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269|PubMed:12097390, ECO:0000269|PubMed:8617796, ECO:0000269|PubMed:9057631}.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; signal transduction [GO:0007165]	B cell receptor complex [GO:0019815]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]	B cell receptor complex [GO:0019815]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.
P40261	reviewed	NNMT_HUMAN	Nicotinamide N-methyltransferase (EC 2.1.1.1)	NNMT	Homo sapiens (Human)	264	FUNCTION: Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:8182091, PubMed:21823666, PubMed:23455543). Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3 (PubMed:26571212, PubMed:23455543, PubMed:31043742). In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (PubMed:26571212). Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (PubMed:30044909). {ECO:0000250|UniProtKB:O55239, ECO:0000269|PubMed:21823666, ECO:0000269|PubMed:23455543, ECO:0000269|PubMed:26571212, ECO:0000269|PubMed:30044909, ECO:0000269|PubMed:31043742, ECO:0000269|PubMed:8182091}.	MISCELLANEOUS: Prominently expressed in the stroma of high-grade serous carcinomas (PubMed:31043742). In tumorigenesis, regulates the epigenetic reprograming of cancer cells associated with increased cell migration and metastasis (PubMed:23455543, PubMed:31043742). {ECO:0000269|PubMed:23455543, ECO:0000269|PubMed:31043742}.	animal organ regeneration [GO:0031100]; methylation [GO:0032259]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinamide metabolic process [GO:0006769]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein deacetylation [GO:0090312]; response to organonitrogen compound [GO:0010243]; response to xenobiotic stimulus [GO:0009410]	cytosol [GO:0005829]	nicotinamide N-methyltransferase activity [GO:0008112]; pyridine N-methyltransferase activity [GO:0030760]	cytosol [GO:0005829]; nicotinamide N-methyltransferase activity [GO:0008112]; pyridine N-methyltransferase activity [GO:0030760]; animal organ regeneration [GO:0031100]; methylation [GO:0032259]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinamide metabolic process [GO:0006769]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein deacetylation [GO:0090312]; response to organonitrogen compound [GO:0010243]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasm.
P40305	reviewed	IFI27_HUMAN	Interferon alpha-inducible protein 27, mitochondrial (p27) (Interferon alpha-induced 11.5 kDa protein) (Interferon-stimulated gene 12a protein) (ISG12(a)) (ISG12A)	IFI27	Homo sapiens (Human)	122	FUNCTION: Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077). Promotes also virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21 (PubMed:36426955). {ECO:0000250|UniProtKB:Q8R412, ECO:0000269|PubMed:18330707, ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:24970806, ECO:0000269|PubMed:27194766, ECO:0000269|PubMed:27673746, ECO:0000269|PubMed:27777077, ECO:0000269|PubMed:36426955}.	MISCELLANEOUS: [Isoform 3]: Major isoform in blood and cervix. {ECO:0000269|PubMed:12878323}.	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; innate immune response [GO:0045087]; modulation by host of viral genome replication [GO:0044827]; negative regulation of transcription by RNA polymerase II [GO:0000122]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; pyroptosis [GO:0070269]; regulation of protein export from nucleus [GO:0046825]; type I interferon-mediated signaling pathway [GO:0060337]	endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]	identical protein binding [GO:0042802]; lamin binding [GO:0005521]; molecular adaptor activity [GO:0060090]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; molecular adaptor activity [GO:0060090]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; innate immune response [GO:0045087]; modulation by host of viral genome replication [GO:0044827]; negative regulation of transcription by RNA polymerase II [GO:0000122]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; pyroptosis [GO:0070269]; regulation of protein export from nucleus [GO:0046825]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:18330707, ECO:0000269|PubMed:27673746, ECO:0000269|PubMed:36426955}; Multi-pass membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000269|PubMed:11722583, ECO:0000269|PubMed:22427340}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22427340}; Multi-pass membrane protein {ECO:0000255}. Note=Exclusive localizations in either the nucleus or the mitochondrion have been reported. {ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:27673746, ECO:0000269|PubMed:36426955}.
P40306	reviewed	PSB10_HUMAN	Proteasome subunit beta type-10 (EC 3.4.25.1) (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i)	PSMB10 LMP10 MECL1	Homo sapiens (Human)	273	FUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.		cell morphogenesis [GO:0000902]; humoral immune response [GO:0006959]; proteasomal protein catabolic process [GO:0010498]; T cell proliferation [GO:0042098]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; spermatoproteasome complex [GO:1990111]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; spermatoproteasome complex [GO:1990111]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; cell morphogenesis [GO:0000902]; humoral immune response [GO:0006959]; proteasomal protein catabolic process [GO:0010498]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
P40337	reviewed	VHL_HUMAN	von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)	VHL	Homo sapiens (Human)	213	FUNCTION: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272). {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:34290272}.	MISCELLANEOUS: [Isoform 1]: Major isoform.; MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation at Met-54 of isoform 1. {ECO:0000305}.	amyloid fibril formation [GO:1990000]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cell morphogenesis [GO:0000902]; cellular response to hypoxia [GO:0071456]; ciliary body morphogenesis [GO:0061073]; endothelial cell differentiation [GO:0045446]; extracellular matrix organization [GO:0030198]; eye pigmentation [GO:0048069]; homeostasis of number of retina cells [GO:0048877]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; iris morphogenesis [GO:0061072]; melanin metabolic process [GO:0006582]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of gene expression [GO:0010629]; negative regulation of hypoxia-inducible factor-1alpha signaling pathway [GO:1902072]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; neuron differentiation [GO:0030182]; pancreatic A cell differentiation [GO:0003310]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of catecholamine metabolic process [GO:0042069]; regulation of cellular response to hypoxia [GO:1900037]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; regulation protein catabolic process at postsynapse [GO:0140252]; response to ethanol [GO:0045471]; selective autophagy [GO:0061912]; type B pancreatic cell differentiation [GO:0003309]	cilium [GO:0005929]; Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; intracellular non-membrane-bounded organelle [GO:0043232]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; VCB complex [GO:0030891]	DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; transcription elongation factor activity [GO:0003711]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]	cilium [GO:0005929]; Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; intracellular non-membrane-bounded organelle [GO:0043232]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; VCB complex [GO:0030891]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; transcription elongation factor activity [GO:0003711]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]; amyloid fibril formation [GO:1990000]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cell morphogenesis [GO:0000902]; cellular response to hypoxia [GO:0071456]; ciliary body morphogenesis [GO:0061073]; endothelial cell differentiation [GO:0045446]; extracellular matrix organization [GO:0030198]; eye pigmentation [GO:0048069]; homeostasis of number of retina cells [GO:0048877]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; iris morphogenesis [GO:0061072]; melanin metabolic process [GO:0006582]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of gene expression [GO:0010629]; negative regulation of hypoxia-inducible factor-1alpha signaling pathway [GO:1902072]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; neuron differentiation [GO:0030182]; pancreatic A cell differentiation [GO:0003310]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of catecholamine metabolic process [GO:0042069]; regulation of cellular response to hypoxia [GO:1900037]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; regulation protein catabolic process at postsynapse [GO:0140252]; response to ethanol [GO:0045471]; selective autophagy [GO:0061912]; type B pancreatic cell differentiation [GO:0003309]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:9751722}. Cell membrane {ECO:0000269|PubMed:19584355}; Peripheral membrane protein {ECO:0000269|PubMed:9751722}. Endoplasmic reticulum {ECO:0000269|PubMed:12169691, ECO:0000269|PubMed:34290272}. Nucleus {ECO:0000269|PubMed:9751722}. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated (PubMed:9751722). Colocalizes with ADRB2 at the cell membrane (PubMed:19584355). {ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:9751722}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:9751722}. Nucleus {ECO:0000269|PubMed:9751722}. Note=Equally distributed between the nucleus and the cytoplasm but not membrane-associated. {ECO:0000269|PubMed:9751722}.
P40394	reviewed	ADH7_HUMAN	All-trans-retinol dehydrogenase [NAD(+)] ADH7 (EC 1.1.1.105) (Alcohol dehydrogenase class 4 mu/sigma chain) (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Gastric alcohol dehydrogenase) (Omega-hydroxydecanoate dehydrogenase ADH7) (EC 1.1.1.66) (Retinol dehydrogenase)	ADH7	Homo sapiens (Human)	386	FUNCTION: Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid (PubMed:15369820, PubMed:16787387, PubMed:9600267). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387, PubMed:15369820). Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation (PubMed:9600267, PubMed:15369820, PubMed:16787387). {ECO:0000269|PubMed:15369820, ECO:0000269|PubMed:16787387, ECO:0000269|PubMed:9600267}.	MISCELLANEOUS: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.	ethanol oxidation [GO:0006069]; fatty acid omega-oxidation [GO:0010430]; response to bacterium [GO:0009617]; response to ethanol [GO:0045471]; retinoic acid metabolic process [GO:0042573]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	alcohol dehydrogenase (NAD+) activity [GO:0004022]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; aldehyde oxidase activity [GO:0004031]; ethanol binding [GO:0035276]; NAD-retinol dehydrogenase activity [GO:0004745]; omega-hydroxydecanoate dehydrogenase activity [GO:0050153]; receptor antagonist activity [GO:0048019]; retinol binding [GO:0019841]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; alcohol dehydrogenase (NAD+) activity [GO:0004022]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; aldehyde oxidase activity [GO:0004031]; ethanol binding [GO:0035276]; NAD-retinol dehydrogenase activity [GO:0004745]; omega-hydroxydecanoate dehydrogenase activity [GO:0050153]; receptor antagonist activity [GO:0048019]; retinol binding [GO:0019841]; zinc ion binding [GO:0008270]; ethanol oxidation [GO:0006069]; fatty acid omega-oxidation [GO:0010430]; response to bacterium [GO:0009617]; response to ethanol [GO:0045471]; retinoic acid metabolic process [GO:0042573]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]	SUBCELLULAR LOCATION: Cytoplasm.
P40424	reviewed	PBX1_HUMAN	Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL)	PBX1 PRL	Homo sapiens (Human)	430	FUNCTION: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (PubMed:9191052). Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (PubMed:9191052). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:8327485, PubMed:7791786). Acts as a transcriptional activator of PF4 in complex with MEIS1 (PubMed:12609849). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (By similarity). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (By similarity). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (By similarity). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4 (PubMed:21746878). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (By similarity). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). {ECO:0000250|UniProtKB:P41778, ECO:0000269|PubMed:12609849, ECO:0000269|PubMed:21746878, ECO:0000269|PubMed:7791786, ECO:0000269|PubMed:8327485, ECO:0000269|PubMed:9191052}.; FUNCTION: [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. {ECO:0000250|UniProtKB:P41778}.		adrenal gland development [GO:0030325]; animal organ morphogenesis [GO:0009887]; anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; embryonic hemopoiesis [GO:0035162]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; embryonic skeletal system development [GO:0048706]; eye development [GO:0001654]; G2/M transition of mitotic cell cycle [GO:0000086]; natural killer cell differentiation [GO:0001779]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of neuron differentiation [GO:0045665]; neuron development [GO:0048666]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of ossification [GO:0030278]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]; spleen development [GO:0048536]; stem cell proliferation [GO:0072089]; steroid biosynthetic process [GO:0006694]; thymus development [GO:0048538]; urogenital system development [GO:0001655]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; adrenal gland development [GO:0030325]; animal organ morphogenesis [GO:0009887]; anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; embryonic hemopoiesis [GO:0035162]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; embryonic skeletal system development [GO:0048706]; eye development [GO:0001654]; G2/M transition of mitotic cell cycle [GO:0000086]; natural killer cell differentiation [GO:0001779]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of neuron differentiation [GO:0045665]; neuron development [GO:0048666]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of ossification [GO:0030278]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]; spleen development [GO:0048536]; stem cell proliferation [GO:0072089]; steroid biosynthetic process [GO:0006694]; thymus development [GO:0048538]; urogenital system development [GO:0001655]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28270404}.
P40425	reviewed	PBX2_HUMAN	Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17)	PBX2 G17	Homo sapiens (Human)	430	FUNCTION: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. {ECO:0000269|PubMed:12609849}.		animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P40426	reviewed	PBX3_HUMAN	Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3)	PBX3	Homo sapiens (Human)	434	FUNCTION: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.		adult locomotory behavior [GO:0008344]; animal organ morphogenesis [GO:0009887]; anterior compartment pattern formation [GO:0007387]; brain development [GO:0007420]; dorsal spinal cord development [GO:0021516]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; posterior compartment specification [GO:0007388]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory gaseous exchange by respiratory system [GO:0007585]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; adult locomotory behavior [GO:0008344]; animal organ morphogenesis [GO:0009887]; anterior compartment pattern formation [GO:0007387]; brain development [GO:0007420]; dorsal spinal cord development [GO:0021516]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; posterior compartment specification [GO:0007388]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P40429	reviewed	RL13A_HUMAN	Large ribosomal subunit protein uL13 (23 kDa highly basic protein) (60S ribosomal protein L13a)	RPL13A	Homo sapiens (Human)	203	FUNCTION: Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:14567916, PubMed:17218275, PubMed:23636399, PubMed:32669547). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (PubMed:23071094). Involved in methylation of rRNA (PubMed:17921318). {ECO:0000269|PubMed:14567916, ECO:0000269|PubMed:17218275, ECO:0000269|PubMed:17921318, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cellular response to type II interferon [GO:0071346]; cytoplasmic translation [GO:0002181]; homeostatic process [GO:0042592]; lung morphogenesis [GO:0060425]; macrophage chemotaxis [GO:0048246]; negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; response to lipopolysaccharide [GO:0032496]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; GAIT complex [GO:0097452]; large ribosomal subunit [GO:0015934]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; synapse [GO:0045202]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; GAIT complex [GO:0097452]; large ribosomal subunit [GO:0015934]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; synapse [GO:0045202]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular response to type II interferon [GO:0071346]; cytoplasmic translation [GO:0002181]; homeostatic process [GO:0042592]; lung morphogenesis [GO:0060425]; macrophage chemotaxis [GO:0048246]; negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; response to lipopolysaccharide [GO:0032496]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399, ECO:0000305|PubMed:14567916}.
P40616	reviewed	ARL1_HUMAN	ADP-ribosylation factor-like protein 1	ARL1	Homo sapiens (Human)	181	FUNCTION: GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex (PubMed:9624189, PubMed:21239483, PubMed:27436755, PubMed:22679020, PubMed:27373159). Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:21239483, ECO:0000269|PubMed:22679020, ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:27373159, ECO:0000269|PubMed:27436755, ECO:0000269|PubMed:9624189}.		activation of phospholipase D activity [GO:0031584]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein localization to Golgi apparatus [GO:0034067]; retrograde transport, endosome to Golgi [GO:0042147]; toxin metabolic process [GO:0009404]; vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	enzyme activator activity [GO:0008047]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; enzyme activator activity [GO:0008047]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; activation of phospholipase D activity [GO:0031584]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein localization to Golgi apparatus [GO:0034067]; retrograde transport, endosome to Golgi [GO:0042147]; toxin metabolic process [GO:0009404]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11303027}; Peripheral membrane protein {ECO:0000269|PubMed:11303027}; Cytoplasmic side {ECO:0000269|PubMed:11303027}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21239483, ECO:0000269|PubMed:27373159, ECO:0000269|PubMed:27436755}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
P40617	reviewed	ARL4A_HUMAN	ADP-ribosylation factor-like protein 4A	ARL4A ARL4	Homo sapiens (Human)	200	FUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. {ECO:0000269|PubMed:10980193, ECO:0000269|PubMed:17398095}.		brown fat cell differentiation [GO:0050873]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; brown fat cell differentiation [GO:0050873]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is dependent by nucleotide binding.
P40692	reviewed	MLH1_HUMAN	DNA mismatch repair protein Mlh1 (MutL protein homolog 1)	MLH1 COCA2	Homo sapiens (Human)	756	FUNCTION: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:20020535, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:9311737}.		double-strand break repair via nonhomologous end joining [GO:0006303]; female meiosis chromosome segregation [GO:0016321]; homologous chromosome pairing at meiosis [GO:0007129]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; isotype switching [GO:0045190]; male meiosis chromosome segregation [GO:0007060]; meiotic metaphase I chromosome alignment [GO:0043060]; meiotic spindle midzone assembly [GO:0051257]; meiotic telomere clustering [GO:0045141]; mismatch repair [GO:0006298]; negative regulation of mitotic recombination [GO:0045950]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; oogenesis [GO:0048477]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; resolution of meiotic recombination intermediates [GO:0000712]; response to bacterium [GO:0009617]; somatic hypermutation of immunoglobulin genes [GO:0016446]; spermatogenesis [GO:0007283]	chiasma [GO:0005712]; chromosome [GO:0005694]; late recombination nodule [GO:0005715]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; MutLalpha complex [GO:0032389]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; guanine/thymine mispair binding [GO:0032137]	chiasma [GO:0005712]; chromosome [GO:0005694]; late recombination nodule [GO:0005715]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; MutLalpha complex [GO:0032389]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; guanine/thymine mispair binding [GO:0032137]; double-strand break repair via nonhomologous end joining [GO:0006303]; female meiosis chromosome segregation [GO:0016321]; homologous chromosome pairing at meiosis [GO:0007129]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; isotype switching [GO:0045190]; male meiosis chromosome segregation [GO:0007060]; meiotic metaphase I chromosome alignment [GO:0043060]; meiotic spindle midzone assembly [GO:0051257]; meiotic telomere clustering [GO:0045141]; mismatch repair [GO:0006298]; negative regulation of mitotic recombination [GO:0045950]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; oogenesis [GO:0048477]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; resolution of meiotic recombination intermediates [GO:0000712]; response to bacterium [GO:0009617]; somatic hypermutation of immunoglobulin genes [GO:0016446]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11429708, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:22753075}. Chromosome {ECO:0000269|PubMed:26300262}. Note=Recruited to chromatin in a MCM9-dependent manner. {ECO:0000269|PubMed:26300262}.
P40763	reviewed	STAT3_HUMAN	Signal transducer and activator of transcription 3 (Acute-phase response factor)	STAT3 APRF	Homo sapiens (Human)	770	FUNCTION: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:22306293, PubMed:23084476, PubMed:32929201). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214, PubMed:32929201). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). {ECO:0000250|UniProtKB:P42227, ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:12359225, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15194700, ECO:0000269|PubMed:17344214, ECO:0000269|PubMed:18242580, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:28065600, ECO:0000269|PubMed:32929201}.	MISCELLANEOUS: Involved in the gp130-mediated signaling pathway.	astrocyte differentiation [GO:0048708]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cellular response to hormone stimulus [GO:0032870]; cellular response to interleukin-17 [GO:0097398]; cellular response to leptin stimulus [GO:0044320]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eating behavior [GO:0042755]; energy homeostasis [GO:0097009]; eye photoreceptor cell differentiation [GO:0001754]; glucose homeostasis [GO:0042593]; growth hormone receptor signaling pathway [GO:0060396]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; inflammatory response [GO:0006954]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-6-mediated signaling pathway [GO:0070102]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular receptor signaling pathway [GO:0030522]; leptin-mediated signaling pathway [GO:0033210]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response [GO:0050728]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of neuron migration [GO:2001223]; negative regulation of primary miRNA processing [GO:2000635]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of metalloendopeptidase activity [GO:1904685]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein import into nucleus [GO:0006606]; radial glial cell differentiation [GO:0060019]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of feeding behavior [GO:0060259]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to leptin [GO:0044321]; response to peptide hormone [GO:0043434]; retinal rod cell differentiation [GO:0060221]; sexual reproduction [GO:0019953]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; T-helper 17 cell lineage commitment [GO:0072540]; T-helper 17 type immune response [GO:0072538]; temperature homeostasis [GO:0001659]; transforming growth factor beta receptor signaling pathway [GO:0007179]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; nuclear receptor activity [GO:0004879]; primary miRNA binding [GO:0070878]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA sequestering activity [GO:0140610]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; nuclear receptor activity [GO:0004879]; primary miRNA binding [GO:0070878]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA sequestering activity [GO:0140610]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; transcription cis-regulatory region binding [GO:0000976]; astrocyte differentiation [GO:0048708]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cellular response to hormone stimulus [GO:0032870]; cellular response to interleukin-17 [GO:0097398]; cellular response to leptin stimulus [GO:0044320]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eating behavior [GO:0042755]; energy homeostasis [GO:0097009]; eye photoreceptor cell differentiation [GO:0001754]; glucose homeostasis [GO:0042593]; growth hormone receptor signaling pathway [GO:0060396]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; inflammatory response [GO:0006954]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-6-mediated signaling pathway [GO:0070102]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular receptor signaling pathway [GO:0030522]; leptin-mediated signaling pathway [GO:0033210]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response [GO:0050728]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of neuron migration [GO:2001223]; negative regulation of primary miRNA processing [GO:2000635]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of metalloendopeptidase activity [GO:1904685]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein import into nucleus [GO:0006606]; radial glial cell differentiation [GO:0060019]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of feeding behavior [GO:0060259]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to leptin [GO:0044321]; response to peptide hormone [GO:0043434]; retinal rod cell differentiation [GO:0060221]; sexual reproduction [GO:0019953]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; T-helper 17 cell lineage commitment [GO:0072540]; T-helper 17 type immune response [GO:0072538]; temperature homeostasis [GO:0001659]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28065600, ECO:0000269|PubMed:31899195}. Nucleus {ECO:0000269|PubMed:28065600, ECO:0000269|PubMed:31899195}. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
P40818	reviewed	UBP8_HUMAN	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)	USP8 KIAA0055 UBPY	Homo sapiens (Human)	1118	FUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}.		cellular response to dexamethasone stimulus [GO:0071549]; cellular response to nerve growth factor stimulus [GO:1990090]; endosome organization [GO:0007032]; mitotic cytokinesis [GO:0000281]; negative regulation of lysosomal protein catabolic process [GO:1905166]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; Ras protein signal transduction [GO:0007265]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extrinsic component of plasma membrane [GO:0019897]; glutamatergic synapse [GO:0098978]; midbody [GO:0030496]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	cadherin binding [GO:0045296]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extrinsic component of plasma membrane [GO:0019897]; glutamatergic synapse [GO:0098978]; midbody [GO:0030496]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; cadherin binding [GO:0045296]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; SH3 domain binding [GO:0017124]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to nerve growth factor stimulus [GO:1990090]; endosome organization [GO:0007032]; mitotic cytokinesis [GO:0000281]; negative regulation of lysosomal protein catabolic process [GO:1905166]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; Ras protein signal transduction [GO:0007265]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:19427866, ECO:0000269|PubMed:28505279}. Nucleus {ECO:0000250|UniProtKB:Q80U87}. Endosome membrane {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858}; Peripheral membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:16520378}; Peripheral membrane protein {ECO:0000305}.
P40855	reviewed	PEX19_HUMAN	Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein)	PEX19 HK33 PXF OK/SW-cl.22	Homo sapiens (Human)	299	FUNCTION: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:11883941, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:15007061}.	MISCELLANEOUS: [Isoform 1]: The two main transcripts are PXF-all and PXF-delta-2.; MISCELLANEOUS: [Isoform 2]: The two main transcripts are PXF-all and PXF-delta-2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	chaperone-mediated protein folding [GO:0061077]; establishment of protein localization to peroxisome [GO:0072663]; negative regulation of lipid binding [GO:1900131]; peroxisome fission [GO:0016559]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; protein import into peroxisome membrane [GO:0045046]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	ATPase binding [GO:0051117]; peroxisome membrane class-1 targeting sequence binding [GO:0036105]; peroxisome membrane targeting sequence binding [GO:0033328]; protein carrier chaperone [GO:0140597]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; ATPase binding [GO:0051117]; peroxisome membrane class-1 targeting sequence binding [GO:0036105]; peroxisome membrane targeting sequence binding [GO:0033328]; protein carrier chaperone [GO:0140597]; chaperone-mediated protein folding [GO:0061077]; establishment of protein localization to peroxisome [GO:0072663]; negative regulation of lipid binding [GO:1900131]; peroxisome fission [GO:0016559]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; protein import into peroxisome membrane [GO:0045046]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:15007061}. Peroxisome membrane {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:15007061, ECO:0000269|PubMed:27181750, ECO:0000269|PubMed:9339377}; Lipid-anchor {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:9339377}; Cytoplasmic side {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:9339377}. Note=Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes. {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:15007061}.
P40879	reviewed	S26A3_HUMAN	Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3)	SLC26A3 DRA	Homo sapiens (Human)	764	FUNCTION: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity). {ECO:0000250|UniProtKB:Q9WVC8, ECO:0000269|PubMed:16606687, ECO:0000269|PubMed:19321737, ECO:0000269|PubMed:22159084, ECO:0000269|PubMed:22627094}.		cellular response to cAMP [GO:0071320]; intracellular pH elevation [GO:0051454]; membrane hyperpolarization [GO:0060081]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; sperm capacitation [GO:0048240]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116]; cellular response to cAMP [GO:0071320]; intracellular pH elevation [GO:0051454]; membrane hyperpolarization [GO:0060081]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:22159084}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:Q9WVC8}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:19321737, ECO:0000269|PubMed:22627094}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250|UniProtKB:Q9WVC8}.
P40925	reviewed	MDHC_HUMAN	Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase)	MDH1 MDHA	Homo sapiens (Human)	334	FUNCTION: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}.		gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	diiodophenylpyruvate reductase activity [GO:0047860]; hydroxyphenylpyruvate reductase activity [GO:0047995]; L-malate dehydrogenase activity [GO:0030060]; malic enzyme activity [GO:0004470]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; diiodophenylpyruvate reductase activity [GO:0047860]; hydroxyphenylpyruvate reductase activity [GO:0047995]; L-malate dehydrogenase activity [GO:0030060]; malic enzyme activity [GO:0004470]; gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:8786100}.
P40926	reviewed	MDHM_HUMAN	Malate dehydrogenase, mitochondrial (EC 1.1.1.37)	MDH2	Homo sapiens (Human)	338			aerobic respiration [GO:0009060]; gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	L-malate dehydrogenase activity [GO:0030060]; malate dehydrogenase (NADP+) activity [GO:0046554]; protein self-association [GO:0043621]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; L-malate dehydrogenase activity [GO:0030060]; malate dehydrogenase (NADP+) activity [GO:0046554]; protein self-association [GO:0043621]; RNA binding [GO:0003723]; aerobic respiration [GO:0009060]; gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P04636}.
P40933	reviewed	IL15_HUMAN	Interleukin-15 (IL-15)	IL15	Homo sapiens (Human)	162	FUNCTION: Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:15123770). Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines (PubMed:8178155, PubMed:9326248). In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (PubMed:9326248). Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits (PubMed:8026467, PubMed:23104097, PubMed:10233906). Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (PubMed:7568001). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity). {ECO:0000250|UniProtKB:P48346, ECO:0000269|PubMed:10233906, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:23104097, ECO:0000269|PubMed:7568001, ECO:0000269|PubMed:8026467, ECO:0000269|PubMed:8178155, ECO:0000269|PubMed:9326248}.		cell maturation [GO:0048469]; cell-cell signaling [GO:0007267]; extrathymic T cell selection [GO:0045062]; immune response [GO:0006955]; interleukin-15-mediated signaling pathway [GO:0035723]; lymph node development [GO:0048535]; macrophage differentiation [GO:0030225]; natural killer cell differentiation [GO:0001779]; natural killer cell proliferation [GO:0001787]; negative regulation of cold-induced thermogenesis [GO:0120163]; neutrophil activation [GO:0042119]; NK T cell proliferation [GO:0001866]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of immune response [GO:0050778]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein O-linked glycosylation [GO:1904100]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of defense response to virus by host [GO:0050691]; regulation of T cell differentiation [GO:0045580]; signal transduction [GO:0007165]; tyrosine phosphorylation of STAT protein [GO:0007260]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; cell maturation [GO:0048469]; cell-cell signaling [GO:0007267]; extrathymic T cell selection [GO:0045062]; immune response [GO:0006955]; interleukin-15-mediated signaling pathway [GO:0035723]; lymph node development [GO:0048535]; macrophage differentiation [GO:0030225]; natural killer cell differentiation [GO:0001779]; natural killer cell proliferation [GO:0001787]; negative regulation of cold-induced thermogenesis [GO:0120163]; neutrophil activation [GO:0042119]; NK T cell proliferation [GO:0001866]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of immune response [GO:0050778]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein O-linked glycosylation [GO:1904100]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of defense response to virus by host [GO:0050691]; regulation of T cell differentiation [GO:0045580]; signal transduction [GO:0007165]; tyrosine phosphorylation of STAT protein [GO:0007260]	SUBCELLULAR LOCATION: [Isoform IL15-S48AA]: Secreted.; SUBCELLULAR LOCATION: [Isoform IL15-S21AA]: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.
P40937	reviewed	RFC5_HUMAN	Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)	RFC5	Homo sapiens (Human)	340	FUNCTION: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. {ECO:0000269|PubMed:8999859}.		DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]	Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P40938	reviewed	RFC3_HUMAN	Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38)	RFC3	Homo sapiens (Human)	356	FUNCTION: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.		DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; response to organophosphorus [GO:0046683]	Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]	Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; response to organophosphorus [GO:0046683]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P40939	reviewed	ECHA_HUMAN	Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]	HADHA HADH	Homo sapiens (Human)	763	FUNCTION: Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:8135828, PubMed:1550553, PubMed:29915090, PubMed:30850536). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity (PubMed:8135828, PubMed:29915090, PubMed:30850536). Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity (PubMed:23152787). It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP (PubMed:23152787). Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity (PubMed:23152787). {ECO:0000269|PubMed:1550553, ECO:0000269|PubMed:23152787, ECO:0000269|PubMed:29915090, ECO:0000269|PubMed:30850536, ECO:0000269|PubMed:8135828, ECO:0000303|PubMed:29915090, ECO:0000303|PubMed:30850536}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid beta-oxidation [GO:0006635]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]	mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; enoyl-CoA hydratase activity [GO:0004300]; fatty-acyl-CoA binding [GO:0000062]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403]; protein-containing complex binding [GO:0044877]	mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; enoyl-CoA hydratase activity [GO:0004300]; fatty-acyl-CoA binding [GO:0000062]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403]; protein-containing complex binding [GO:0044877]; cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid beta-oxidation [GO:0006635]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:29915090}. Mitochondrion inner membrane {ECO:0000269|PubMed:29915090}. Note=Protein stability and association with mitochondrion inner membrane do not require HADHB. {ECO:0000269|PubMed:29915090}.
P40967	reviewed	PMEL_HUMAN	Melanocyte protein PMEL (ME20-M) (ME20M) (Melanocyte protein Pmel 17) (Melanocytes lineage-specific antigen GP100) (Melanoma-associated ME20 antigen) (P1) (P100) (Premelanosome protein) (Silver locus protein homolog) [Cleaved into: M-alpha (95 kDa melanocyte-specific secreted glycoprotein) (P26) (Secreted melanoma-associated ME20 antigen) (ME20-S) (ME20S); M-beta]	PMEL D12S53E PMEL17 SILV	Homo sapiens (Human)	661	FUNCTION: Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway. {ECO:0000269|PubMed:11694580, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:26387950, ECO:0000269|PubMed:26694611, ECO:0000269|PubMed:28272432, ECO:0000269|PubMed:30988362}.; FUNCTION: Represents a potent melanoma-specific antigen. Among melanoma non-mutated self-peptides, G9-154 (KTWGQYWQV), G9-209 (ITDQVPFSV) and G9-280 (YLEPGPVTA), appear to act as immunodominant common epitopes that stimulate anti-tumor immune response mediated by HLA-A-restricted cytotoxic T cells. {ECO:0000269|PubMed:7706734, ECO:0000269|PubMed:8022805}.		melanin biosynthetic process [GO:0042438]; melanosome organization [GO:0032438]; positive regulation of melanin biosynthetic process [GO:0048023]	cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; multivesicular body membrane [GO:0032585]; multivesicular body, internal vesicle [GO:0097487]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; multivesicular body membrane [GO:0032585]; multivesicular body, internal vesicle [GO:0097487]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; melanin biosynthetic process [GO:0042438]; melanosome organization [GO:0032438]; positive regulation of melanin biosynthetic process [GO:0048023]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15096515, ECO:0000269|PubMed:15695812, ECO:0000269|PubMed:19047044}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:15096515}; Single-pass type I membrane protein {ECO:0000255}. Endosome, multivesicular body {ECO:0000269|PubMed:11694580, ECO:0000269|PubMed:17991747, ECO:0000269|PubMed:19047044, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:26387950}. Melanosome {ECO:0000269|PubMed:11694580, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:15096515, ECO:0000269|PubMed:15695812, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:17991747, ECO:0000269|PubMed:23754390}. Extracellular vesicle {ECO:0000269|PubMed:26387950}. Secreted {ECO:0000269|PubMed:8179825}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes predominantly to intralumenal vesicles (ILVs) within multivesicular bodies. Associates with ILVs found within the lumen of premelanosomes and melanosomes and particularly in compartments that serve as precursors to the striated stage II premelanosomes (PubMed:12643545, PubMed:11694580). Sorted to stage I melanosomes following its processing in the ER and cis-Golgi (PubMed:15096515). Transiently expressed at the cell surface before targeting to early melanosomes (PubMed:30988362, PubMed:16760433). Colocalizes with BACE2 in stage I and II melanosomes (PubMed:23754390). Colocalizes with CD63 and APOE at exosomes and in intraluminal vesicles within multivesicular endosomes (PubMed:26387950, PubMed:21962903). {ECO:0000269|PubMed:11694580, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:15096515, ECO:0000269|PubMed:16760433, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:23754390, ECO:0000269|PubMed:26387950, ECO:0000269|PubMed:30988362}.
P41002	reviewed	CCNF_HUMAN	Cyclin-F (F-box only protein 1)	CCNF FBX1 FBXO1	Homo sapiens (Human)	786	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20596027, PubMed:22632967, PubMed:27653696, PubMed:26818844, PubMed:27080313, PubMed:28852778). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (PubMed:8706131, PubMed:20596027, PubMed:27653696, PubMed:26818844). Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (PubMed:20596027, PubMed:22632967, PubMed:27653696, PubMed:26818844). Mediates the ubiquitination and proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (PubMed:20596027). In G2, mediates the ubiquitination and subsequent degradation of ribonucleotide reductase RRM2, thereby maintaining a balanced pool of dNTPs and genome integrity (PubMed:22632967). In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (PubMed:26818844). Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (PubMed:27653696). May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (PubMed:25557911). {ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:22632967, ECO:0000269|PubMed:25557911, ECO:0000269|PubMed:26818844, ECO:0000269|PubMed:27080313, ECO:0000269|PubMed:27653696, ECO:0000269|PubMed:28852778, ECO:0000269|PubMed:8706131}.	MISCELLANEOUS: Founding member of the F-box domain protein family, which obtained its name from cyclin-F. {ECO:0000305|PubMed:8706131}.; MISCELLANEOUS: Member of the cyclin family, however, unlike most members of the cyclin family, it does not bind or activate a cyclin-dependent kinase. {ECO:0000305|PubMed:7813445}.	cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772]; negative regulation of centrosome duplication [GO:0010826]; placenta development [GO:0001890]; protein ubiquitination [GO:0016567]; re-entry into mitotic cell cycle [GO:0000320]; regulation of cell cycle [GO:0051726]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cell junction [GO:0030054]; centriole [GO:0005814]; centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005]	anaphase-promoting complex binding [GO:0010997]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cell junction [GO:0030054]; centriole [GO:0005814]; centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005]; anaphase-promoting complex binding [GO:0010997]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772]; negative regulation of centrosome duplication [GO:0010826]; placenta development [GO:0001890]; protein ubiquitination [GO:0016567]; re-entry into mitotic cell cycle [GO:0000320]; regulation of cell cycle [GO:0051726]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10716937, ECO:0000269|PubMed:22632967, ECO:0000269|PubMed:26818844, ECO:0000269|PubMed:7813445}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:7813445}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:20596027}. Note=Localization to the centrosome is rare in S phase cells and increases in G2 cells. Localizes to both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Localizes to the nucleus in G2 phase. {ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:26818844}.
P41091	reviewed	IF2G_HUMAN	Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF-2-gamma X) (eIF-2gX)	EIF2S3 EIF2G	Homo sapiens (Human)	472	FUNCTION: Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. {ECO:0000250|UniProtKB:P05198}.	MISCELLANEOUS: Encoded by an chromosome X-linked gene which escapes inactivation. Does not have any homolog on chromosome Y. {ECO:0000269|PubMed:9736774}.	formation of translation preinitiation complex [GO:0001731]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular exosome [GO:0070062]	cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular exosome [GO:0070062]; cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049]; formation of translation preinitiation complex [GO:0001731]; translational initiation [GO:0006413]	
P41134	reviewed	ID1_HUMAN	DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1)	ID1 BHLHB24 ID	Homo sapiens (Human)	155	FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250}.		angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; circadian regulation of gene expression [GO:0032922]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription by transcription factor localization [GO:0010621]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein dimerization activity [GO:0046983]; transcription regulator inhibitor activity [GO:0140416]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein dimerization activity [GO:0046983]; transcription regulator inhibitor activity [GO:0140416]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; circadian regulation of gene expression [GO:0032922]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription by transcription factor localization [GO:0010621]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus.
P41143	reviewed	OPRD_HUMAN	Delta-type opioid receptor (D-OR-1) (DOR-1)	OPRD1 OPRD	Homo sapiens (Human)	372	FUNCTION: G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adult locomotory behavior [GO:0008344]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hypoxia [GO:0071456]; cellular response to toxic substance [GO:0097237]; eating behavior [GO:0042755]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; negative regulation of gene expression [GO:0010629]; negative regulation of protein-containing complex assembly [GO:0031333]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of calcium ion transport [GO:0051924]; regulation of mitochondrial membrane potential [GO:0051881]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuron projection [GO:0043005]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; spine apparatus [GO:0097444]; synaptic vesicle membrane [GO:0030672]	G protein-coupled enkephalin receptor activity [GO:0038046]; G protein-coupled opioid receptor activity [GO:0004985]; neuropeptide binding [GO:0042923]; receptor serine/threonine kinase binding [GO:0033612]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuron projection [GO:0043005]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; spine apparatus [GO:0097444]; synaptic vesicle membrane [GO:0030672]; G protein-coupled enkephalin receptor activity [GO:0038046]; G protein-coupled opioid receptor activity [GO:0004985]; neuropeptide binding [GO:0042923]; receptor serine/threonine kinase binding [GO:0033612]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adult locomotory behavior [GO:0008344]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hypoxia [GO:0071456]; cellular response to toxic substance [GO:0097237]; eating behavior [GO:0042755]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; negative regulation of gene expression [GO:0010629]; negative regulation of protein-containing complex assembly [GO:0031333]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of calcium ion transport [GO:0051924]; regulation of mitochondrial membrane potential [GO:0051881]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}; Multi-pass membrane protein {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}.
P41145	reviewed	OPRK_HUMAN	Kappa-type opioid receptor (K-OR-1) (KOR-1)	OPRK1 OPRK	Homo sapiens (Human)	380	FUNCTION: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting opioid receptor signaling pathway [GO:0031635]; behavioral response to cocaine [GO:0048148]; cellular response to glucose stimulus [GO:0071333]; cellular response to lipopolysaccharide [GO:0071222]; chemical synaptic transmission [GO:0007268]; conditioned place preference [GO:1990708]; defense response to virus [GO:0051607]; eating behavior [GO:0042755]; estrous cycle [GO:0044849]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; immune response [GO:0006955]; locomotory behavior [GO:0007626]; maternal behavior [GO:0042711]; negative regulation of luteinizing hormone secretion [GO:0033685]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of eating behavior [GO:1904000]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of potassium ion transmembrane transport [GO:1901381]; regulation of saliva secretion [GO:0046877]; response to acrylamide [GO:1903937]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]; sensory perception of temperature stimulus [GO:0050951]	axon terminus [GO:0043679]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]	dynorphin receptor activity [GO:0038048]; G protein-coupled opioid receptor activity [GO:0004985]; neuropeptide binding [GO:0042923]; receptor serine/threonine kinase binding [GO:0033612]	axon terminus [GO:0043679]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; dynorphin receptor activity [GO:0038048]; G protein-coupled opioid receptor activity [GO:0004985]; neuropeptide binding [GO:0042923]; receptor serine/threonine kinase binding [GO:0033612]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting opioid receptor signaling pathway [GO:0031635]; behavioral response to cocaine [GO:0048148]; cellular response to glucose stimulus [GO:0071333]; cellular response to lipopolysaccharide [GO:0071222]; chemical synaptic transmission [GO:0007268]; conditioned place preference [GO:1990708]; defense response to virus [GO:0051607]; eating behavior [GO:0042755]; estrous cycle [GO:0044849]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; immune response [GO:0006955]; locomotory behavior [GO:0007626]; maternal behavior [GO:0042711]; negative regulation of luteinizing hormone secretion [GO:0033685]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of eating behavior [GO:1904000]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of potassium ion transmembrane transport [GO:1901381]; regulation of saliva secretion [GO:0046877]; response to acrylamide [GO:1903937]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]; sensory perception of temperature stimulus [GO:0050951]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}; Multi-pass membrane protein {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
P41146	reviewed	OPRX_HUMAN	Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor)	OPRL1 OOR ORL1	Homo sapiens (Human)	370	FUNCTION: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:11238602, ECO:0000269|PubMed:12568343, ECO:0000269|PubMed:22596163, ECO:0000269|PubMed:23086955, ECO:0000269|PubMed:8137918}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; conditioned place preference [GO:1990708]; eating behavior [GO:0042755]; estrous cycle [GO:0044849]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of blood pressure [GO:0045776]; negative regulation of cAMP-mediated signaling [GO:0043951]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of urine volume [GO:0035810]; regulation of locomotor rhythm [GO:1904059]; response to estradiol [GO:0032355]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]	cytoplasmic vesicle [GO:0031410]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; nociceptin receptor activity [GO:0001626]	cytoplasmic vesicle [GO:0031410]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; nociceptin receptor activity [GO:0001626]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; conditioned place preference [GO:1990708]; eating behavior [GO:0042755]; estrous cycle [GO:0044849]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of blood pressure [GO:0045776]; negative regulation of cAMP-mediated signaling [GO:0043951]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of urine volume [GO:0035810]; regulation of locomotor rhythm [GO:1904059]; response to estradiol [GO:0032355]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.
P41159	reviewed	LEP_HUMAN	Leptin (Obese protein) (Obesity factor)	LEP OB OBS	Homo sapiens (Human)	167	FUNCTION: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:17344214, PubMed:15899045, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:8589726, PubMed:11460888, PubMed:19688109, PubMed:24340098, PubMed:25060689). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (PubMed:24340098). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:17344214). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (PubMed:18242580). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:11460888). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (PubMed:12504075). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (PubMed:15899045, PubMed:19688109). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (PubMed:25060689). {ECO:0000250|UniProtKB:P41160, ECO:0000250|UniProtKB:P50596, ECO:0000269|PubMed:11460888, ECO:0000269|PubMed:12504075, ECO:0000269|PubMed:15899045, ECO:0000269|PubMed:17344214, ECO:0000269|PubMed:18242580, ECO:0000269|PubMed:19688109, ECO:0000269|PubMed:24340098, ECO:0000269|PubMed:25060689, ECO:0000269|PubMed:8589726, ECO:0000305|PubMed:15122202, ECO:0000305|PubMed:25232147}.		activation of protein kinase C activity [GO:1990051]; adipose tissue development [GO:0060612]; adult feeding behavior [GO:0008343]; angiogenesis [GO:0001525]; aorta development [GO:0035904]; bile acid metabolic process [GO:0008206]; bone growth [GO:0098868]; bone mineralization involved in bone maturation [GO:0035630]; cardiac muscle hypertrophy [GO:0003300]; cellular response to insulin stimulus [GO:0032869]; cellular response to L-ascorbic acid [GO:0071298]; cellular response to leptin stimulus [GO:0044320]; cellular response to retinoic acid [GO:0071300]; central nervous system neuron development [GO:0021954]; cholesterol metabolic process [GO:0008203]; circadian rhythm [GO:0007623]; determination of adult lifespan [GO:0008340]; eating behavior [GO:0042755]; elastin metabolic process [GO:0051541]; energy reserve metabolic process [GO:0006112]; fatty acid beta-oxidation [GO:0006635]; female pregnancy [GO:0007565]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycerol biosynthetic process [GO:0006114]; hormone metabolic process [GO:0042445]; insulin secretion [GO:0030073]; intestinal absorption [GO:0050892]; intracellular signal transduction [GO:0035556]; leptin-mediated signaling pathway [GO:0033210]; leukocyte tethering or rolling [GO:0050901]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; negative regulation of appetite [GO:0032099]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of autophagy [GO:0010507]; negative regulation of cartilage development [GO:0061037]; negative regulation of glucagon secretion [GO:0070093]; negative regulation of glucose import [GO:0046325]; negative regulation of glutamine transport [GO:2000486]; negative regulation of lipid storage [GO:0010888]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vasoconstriction [GO:0045906]; ovulation from ovarian follicle [GO:0001542]; phagocytosis [GO:0006909]; placenta development [GO:0001890]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of developmental growth [GO:0048639]; positive regulation of fat cell apoptotic process [GO:1904651]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of monoatomic ion transport [GO:0043270]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of TOR signaling [GO:0032008]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; prostaglandin secretion [GO:0032310]; regulation of angiogenesis [GO:0045765]; regulation of blood pressure [GO:0008217]; regulation of bone remodeling [GO:0046850]; regulation of brown fat cell differentiation [GO:0090335]; regulation of cell cycle [GO:0051726]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of endothelial cell proliferation [GO:0001936]; regulation of gluconeogenesis [GO:0006111]; regulation of insulin secretion [GO:0050796]; regulation of intestinal cholesterol absorption [GO:0030300]; regulation of lipoprotein lipid oxidation [GO:0060587]; regulation of natural killer cell activation [GO:0032814]; regulation of natural killer cell mediated cytotoxicity [GO:0042269]; regulation of natural killer cell proliferation [GO:0032817]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of steroid biosynthetic process [GO:0050810]; response to activity [GO:0014823]; response to dietary excess [GO:0002021]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to vitamin E [GO:0033197]; sexual reproduction [GO:0019953]; T cell differentiation [GO:0030217]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	DNA binding [GO:0003677]; hormone activity [GO:0005179]; leptin receptor binding [GO:1990460]; peptide hormone receptor binding [GO:0051428]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; DNA binding [GO:0003677]; hormone activity [GO:0005179]; leptin receptor binding [GO:1990460]; peptide hormone receptor binding [GO:0051428]; activation of protein kinase C activity [GO:1990051]; adipose tissue development [GO:0060612]; adult feeding behavior [GO:0008343]; angiogenesis [GO:0001525]; aorta development [GO:0035904]; bile acid metabolic process [GO:0008206]; bone growth [GO:0098868]; bone mineralization involved in bone maturation [GO:0035630]; cardiac muscle hypertrophy [GO:0003300]; cellular response to insulin stimulus [GO:0032869]; cellular response to L-ascorbic acid [GO:0071298]; cellular response to leptin stimulus [GO:0044320]; cellular response to retinoic acid [GO:0071300]; central nervous system neuron development [GO:0021954]; cholesterol metabolic process [GO:0008203]; circadian rhythm [GO:0007623]; determination of adult lifespan [GO:0008340]; eating behavior [GO:0042755]; elastin metabolic process [GO:0051541]; energy reserve metabolic process [GO:0006112]; fatty acid beta-oxidation [GO:0006635]; female pregnancy [GO:0007565]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycerol biosynthetic process [GO:0006114]; hormone metabolic process [GO:0042445]; insulin secretion [GO:0030073]; intestinal absorption [GO:0050892]; intracellular signal transduction [GO:0035556]; leptin-mediated signaling pathway [GO:0033210]; leukocyte tethering or rolling [GO:0050901]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; negative regulation of appetite [GO:0032099]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of autophagy [GO:0010507]; negative regulation of cartilage development [GO:0061037]; negative regulation of glucagon secretion [GO:0070093]; negative regulation of glucose import [GO:0046325]; negative regulation of glutamine transport [GO:2000486]; negative regulation of lipid storage [GO:0010888]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vasoconstriction [GO:0045906]; ovulation from ovarian follicle [GO:0001542]; phagocytosis [GO:0006909]; placenta development [GO:0001890]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of developmental growth [GO:0048639]; positive regulation of fat cell apoptotic process [GO:1904651]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of monoatomic ion transport [GO:0043270]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of TOR signaling [GO:0032008]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; prostaglandin secretion [GO:0032310]; regulation of angiogenesis [GO:0045765]; regulation of blood pressure [GO:0008217]; regulation of bone remodeling [GO:0046850]; regulation of brown fat cell differentiation [GO:0090335]; regulation of cell cycle [GO:0051726]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of endothelial cell proliferation [GO:0001936]; regulation of gluconeogenesis [GO:0006111]; regulation of insulin secretion [GO:0050796]; regulation of intestinal cholesterol absorption [GO:0030300]; regulation of lipoprotein lipid oxidation [GO:0060587]; regulation of natural killer cell activation [GO:0032814]; regulation of natural killer cell mediated cytotoxicity [GO:0042269]; regulation of natural killer cell proliferation [GO:0032817]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of steroid biosynthetic process [GO:0050810]; response to activity [GO:0014823]; response to dietary excess [GO:0002021]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to vitamin E [GO:0033197]; sexual reproduction [GO:0019953]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:25232147}.
P41161	reviewed	ETV5_HUMAN	ETS translocation variant 5 (Ets-related protein ERM)	ETV5 ERM	Homo sapiens (Human)	510	FUNCTION: Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. {ECO:0000269|PubMed:8152800}.		cellular response to oxidative stress [GO:0034599]; male germ-line stem cell asymmetric division [GO:0048133]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cellular response to oxidative stress [GO:0034599]; male germ-line stem cell asymmetric division [GO:0048133]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P41162	reviewed	ETV3_HUMAN	ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor)	ETV3 METS PE1	Homo sapiens (Human)	512	FUNCTION: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}.		cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; negative regulation of cell population proliferation [GO:0008285]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571]	DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571]; DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; negative regulation of cell population proliferation [GO:0008285]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
P41180	reviewed	CASR_HUMAN	Extracellular calcium-sensing receptor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1)	CASR GPRC2A PCAR1	Homo sapiens (Human)	1078	FUNCTION: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547). {ECO:0000250|UniProtKB:Q9QY96, ECO:0000269|PubMed:17555508, ECO:0000269|PubMed:19789209, ECO:0000269|PubMed:21566075, ECO:0000269|PubMed:22114145, ECO:0000269|PubMed:22789683, ECO:0000269|PubMed:23966241, ECO:0000269|PubMed:25104082, ECO:0000269|PubMed:25292184, ECO:0000269|PubMed:25766501, ECO:0000269|PubMed:26386835, ECO:0000269|PubMed:27386547, ECO:0000269|PubMed:27434672, ECO:0000269|PubMed:7759551, ECO:0000269|PubMed:8636323, ECO:0000269|PubMed:8702647, ECO:0000269|PubMed:8878438}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; anatomical structure morphogenesis [GO:0009653]; bile acid secretion [GO:0032782]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium ion import [GO:0070509]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to hypoxia [GO:0071456]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to peptide [GO:1901653]; cellular response to vitamin D [GO:0071305]; chemosensory behavior [GO:0007635]; chloride transmembrane transport [GO:1902476]; detection of calcium ion [GO:0005513]; fat pad development [GO:0060613]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; JNK cascade [GO:0007254]; ossification [GO:0001503]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion [GO:0032024]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of vasoconstriction [GO:0045907]; regulation of calcium ion transport [GO:0051924]; response to fibroblast growth factor [GO:0071774]; response to ischemia [GO:0002931]; vasodilation [GO:0042311]	apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	amino acid binding [GO:0016597]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; phosphatidylinositol phospholipase C activity [GO:0004435]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]	apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; amino acid binding [GO:0016597]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; phosphatidylinositol phospholipase C activity [GO:0004435]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; anatomical structure morphogenesis [GO:0009653]; bile acid secretion [GO:0032782]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium ion import [GO:0070509]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to hypoxia [GO:0071456]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to peptide [GO:1901653]; cellular response to vitamin D [GO:0071305]; chemosensory behavior [GO:0007635]; chloride transmembrane transport [GO:1902476]; detection of calcium ion [GO:0005513]; fat pad development [GO:0060613]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; JNK cascade [GO:0007254]; ossification [GO:0001503]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion [GO:0032024]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of vasoconstriction [GO:0045907]; regulation of calcium ion transport [GO:0051924]; response to fibroblast growth factor [GO:0071774]; response to ischemia [GO:0002931]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15572418, ECO:0000269|PubMed:16740594, ECO:0000269|PubMed:17555508, ECO:0000269|PubMed:19789209, ECO:0000269|PubMed:20861236, ECO:0000269|PubMed:22114145, ECO:0000269|PubMed:22789683, ECO:0000269|PubMed:25104082, ECO:0000269|PubMed:25766501, ECO:0000269|PubMed:26386835, ECO:0000269|PubMed:8702647}; Multi-pass membrane protein {ECO:0000269|PubMed:20861236}.
P41181	reviewed	AQP2_HUMAN	Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct)	AQP2	Homo sapiens (Human)	271	FUNCTION: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:8140421, PubMed:7524315, PubMed:7510718, PubMed:15509592). Plays an essential role in renal water homeostasis (PubMed:8140421, PubMed:7524315, PubMed:15509592). {ECO:0000269|PubMed:15509592, ECO:0000269|PubMed:7510718, ECO:0000269|PubMed:7524315, ECO:0000269|PubMed:8140421}.		actin filament organization [GO:0007015]; cellular response to copper ion [GO:0071280]; cellular response to mercury ion [GO:0071288]; cellular response to water deprivation [GO:0042631]; glycerol transmembrane transport [GO:0015793]; metanephric collecting duct development [GO:0072205]; protein homotetramerization [GO:0051289]; renal water homeostasis [GO:0003091]; renal water transport [GO:0003097]; water transport [GO:0006833]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lumenal side of membrane [GO:0098576]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; transport vesicle membrane [GO:0030658]	glycerol transmembrane transporter activity [GO:0015168]; water channel activity [GO:0015250]; water transmembrane transporter activity [GO:0005372]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lumenal side of membrane [GO:0098576]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; transport vesicle membrane [GO:0030658]; glycerol transmembrane transporter activity [GO:0015168]; water channel activity [GO:0015250]; water transmembrane transporter activity [GO:0005372]; actin filament organization [GO:0007015]; cellular response to copper ion [GO:0071280]; cellular response to mercury ion [GO:0071288]; cellular response to water deprivation [GO:0042631]; glycerol transmembrane transport [GO:0015793]; metanephric collecting duct development [GO:0072205]; protein homotetramerization [GO:0051289]; renal water homeostasis [GO:0003091]; renal water transport [GO:0003097]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12194985, ECO:0000269|PubMed:15509592, ECO:0000269|PubMed:7510718}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985, ECO:0000269|PubMed:24733887}. Basolateral cell membrane {ECO:0000250|UniProtKB:P34080}; Multi-pass membrane protein {ECO:0000269|PubMed:24733887}. Cell membrane {ECO:0000269|PubMed:15509592, ECO:0000269|PubMed:24733887, ECO:0000269|PubMed:7524315, ECO:0000269|PubMed:8140421}; Multi-pass membrane protein {ECO:0000269|PubMed:24733887}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12194985, ECO:0000269|PubMed:15509592}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985, ECO:0000269|PubMed:24733887}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12194985}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985, ECO:0000269|PubMed:24733887}. Note=Shuttles from vesicles to the apical membrane (PubMed:15509592). Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:15509592). PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity). {ECO:0000250|UniProtKB:P34080, ECO:0000269|PubMed:15509592}.
P41182	reviewed	BCL6_HUMAN	B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51)	BCL6 BCL5 LAZ3 ZBTB27 ZNF51	Homo sapiens (Human)	706	FUNCTION: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651, ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:9649500}.		actin cytoskeleton organization [GO:0030036]; B cell proliferation [GO:0042100]; cell morphogenesis [GO:0000902]; cell motility [GO:0048870]; cell-matrix adhesion [GO:0007160]; DNA damage response [GO:0006974]; erythrocyte development [GO:0048821]; germinal center formation [GO:0002467]; heterochromatin formation [GO:0031507]; inflammatory response [GO:0006954]; isotype switching to IgE isotypes [GO:0048289]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cell growth [GO:0030308]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of isotype switching to IgE isotypes [GO:0048294]; negative regulation of leukocyte proliferation [GO:0070664]; negative regulation of mast cell cytokine production [GO:0032764]; negative regulation of mitotic cell cycle DNA replication [GO:1903464]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of plasma cell differentiation [GO:1900099]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; plasma cell differentiation [GO:0002317]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of regulatory T cell differentiation [GO:0045591]; protein localization [GO:0008104]; pyramidal neuron differentiation [GO:0021859]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of cytokine production [GO:0001817]; regulation of germinal center formation [GO:0002634]; regulation of immune response [GO:0050776]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; regulation of memory T cell differentiation [GO:0043380]; regulation of T cell proliferation [GO:0042129]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; T-helper 2 cell differentiation [GO:0045064]; transcription by RNA polymerase II [GO:0006366]; type 2 immune response [GO:0042092]	Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]	chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]	Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]; actin cytoskeleton organization [GO:0030036]; B cell proliferation [GO:0042100]; cell morphogenesis [GO:0000902]; cell motility [GO:0048870]; cell-matrix adhesion [GO:0007160]; DNA damage response [GO:0006974]; erythrocyte development [GO:0048821]; germinal center formation [GO:0002467]; heterochromatin formation [GO:0031507]; inflammatory response [GO:0006954]; isotype switching to IgE isotypes [GO:0048289]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cell growth [GO:0030308]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of isotype switching to IgE isotypes [GO:0048294]; negative regulation of leukocyte proliferation [GO:0070664]; negative regulation of mast cell cytokine production [GO:0032764]; negative regulation of mitotic cell cycle DNA replication [GO:1903464]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of plasma cell differentiation [GO:1900099]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; plasma cell differentiation [GO:0002317]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of regulatory T cell differentiation [GO:0045591]; protein localization [GO:0008104]; pyramidal neuron differentiation [GO:0021859]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of cytokine production [GO:0001817]; regulation of germinal center formation [GO:0002634]; regulation of immune response [GO:0050776]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; regulation of memory T cell differentiation [GO:0043380]; regulation of T cell proliferation [GO:0042129]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; T-helper 2 cell differentiation [GO:0045064]; transcription by RNA polymerase II [GO:0006366]; type 2 immune response [GO:0042092]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356}.
P41208	reviewed	CETN2_HUMAN	Centrin-2 (Caltractin isoform 1)	CETN2 CALT CEN2	Homo sapiens (Human)	172	FUNCTION: Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000269|PubMed:22307388, ECO:0000305|PubMed:23591820}.	MISCELLANEOUS: Binds two moles of calcium per mole of protein.	cell division [GO:0051301]; centriole replication [GO:0007099]; mitotic cell cycle [GO:0000278]; mRNA transport [GO:0051028]; nucleotide-excision repair [GO:0006289]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]; spermatogenesis [GO:0007283]	9+2 motile cilium [GO:0097729]; apical part of cell [GO:0045177]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; transcription export complex 2 [GO:0070390]; XPC complex [GO:0071942]	calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; heterotrimeric G-protein binding [GO:0032795]; microtubule binding [GO:0008017]	9+2 motile cilium [GO:0097729]; apical part of cell [GO:0045177]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; transcription export complex 2 [GO:0070390]; XPC complex [GO:0071942]; calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; heterotrimeric G-protein binding [GO:0032795]; microtubule binding [GO:0008017]; cell division [GO:0051301]; centriole replication [GO:0007099]; mitotic cell cycle [GO:0000278]; mRNA transport [GO:0051028]; nucleotide-excision repair [GO:0006289]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23591820}. Nucleus envelope {ECO:0000269|PubMed:23591820}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:23591820}. Nucleus {ECO:0000305}.
P41212	reviewed	ETV6_HUMAN	Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel)	ETV6 TEL TEL1	Homo sapiens (Human)	452	FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.		hematopoietic stem cell proliferation [GO:0071425]; mesenchymal cell apoptotic process [GO:0097152]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; regulation of transcription by RNA polymerase II [GO:0006357]; vitellogenesis [GO:0007296]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; hematopoietic stem cell proliferation [GO:0071425]; mesenchymal cell apoptotic process [GO:0097152]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; regulation of transcription by RNA polymerase II [GO:0006357]; vitellogenesis [GO:0007296]	SUBCELLULAR LOCATION: Nucleus.
P41214	reviewed	EIF2D_HUMAN	Eukaryotic translation initiation factor 2D (eIF2d) (Hepatocellular carcinoma-associated antigen 56) (Ligatin)	EIF2D HCA56 LGTN	Homo sapiens (Human)	584	FUNCTION: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269|PubMed:20566627, ECO:0000269|PubMed:20713520}.		formation of translation preinitiation complex [GO:0001731]; intracellular protein transport [GO:0006886]; IRES-dependent viral translational initiation [GO:0075522]; ribosome disassembly [GO:0032790]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]	RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; translation initiation factor activity [GO:0003743]; formation of translation preinitiation complex [GO:0001731]; intracellular protein transport [GO:0006886]; IRES-dependent viral translational initiation [GO:0075522]; ribosome disassembly [GO:0032790]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20566627}.
P41217	reviewed	OX2G_HUMAN	OX-2 membrane glycoprotein (CD antigen CD200)	CD200 MOX1 MOX2 My033	Homo sapiens (Human)	278	FUNCTION: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.		cell-cell adhesion [GO:0098609]; heterotypic cell-cell adhesion [GO:0034113]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of leukocyte activation [GO:0002695]; negative regulation of macrophage activation [GO:0043031]; negative regulation of macrophage migration [GO:1905522]; negative regulation of matrix metallopeptidase secretion [GO:1904465]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell migration [GO:2000405]; positive regulation of arginase activity [GO:0150072]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of protein-glutamine gamma-glutamyltransferase activity [GO:0150074]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of immune response [GO:0050776]; regulation of neuroinflammatory response [GO:0150077]	axon [GO:0030424]; cell body [GO:0044297]; cell surface [GO:0009986]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	cell-cell adhesion mediator activity [GO:0098632]; glycosylated region protein binding [GO:0140081]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]	axon [GO:0030424]; cell body [GO:0044297]; cell surface [GO:0009986]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; cell-cell adhesion mediator activity [GO:0098632]; glycosylated region protein binding [GO:0140081]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; cell-cell adhesion [GO:0098609]; heterotypic cell-cell adhesion [GO:0034113]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of leukocyte activation [GO:0002695]; negative regulation of macrophage activation [GO:0043031]; negative regulation of macrophage migration [GO:1905522]; negative regulation of matrix metallopeptidase secretion [GO:1904465]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell migration [GO:2000405]; positive regulation of arginase activity [GO:0150072]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of protein-glutamine gamma-glutamyltransferase activity [GO:0150074]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of immune response [GO:0050776]; regulation of neuroinflammatory response [GO:0150077]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P41218	reviewed	MNDA_HUMAN	Myeloid cell nuclear differentiation antigen	MNDA	Homo sapiens (Human)	407	FUNCTION: May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.		activation of innate immune response [GO:0002218]; B cell receptor signaling pathway [GO:0050853]; cellular defense response [GO:0006968]; cellular response to interferon-beta [GO:0035458]; DNA damage response [GO:0006974]; negative regulation of B cell proliferation [GO:0030889]; positive regulation of apoptotic process [GO:0043065]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	double-stranded DNA binding [GO:0003690]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; double-stranded DNA binding [GO:0003690]; activation of innate immune response [GO:0002218]; B cell receptor signaling pathway [GO:0050853]; cellular defense response [GO:0006968]; cellular response to interferon-beta [GO:0035458]; DNA damage response [GO:0006974]; negative regulation of B cell proliferation [GO:0030889]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.
P41219	reviewed	PERI_HUMAN	Peripherin (Neurofilament 4)	PRPH NEF4 PRPH1	Homo sapiens (Human)	470	FUNCTION: Class-III neuronal intermediate filament protein (By similarity). May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (PubMed:15446584, PubMed:15322088). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (By similarity). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity). {ECO:0000250|UniProtKB:P15331, ECO:0000250|UniProtKB:P21807, ECO:0000269|PubMed:15322088, ECO:0000269|PubMed:15446584}.	MISCELLANEOUS: [Isoform 2]: Gene prediction based on similarity to orthologs. {ECO:0000305}.		axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; type III intermediate filament [GO:0045098]	structural molecule activity [GO:0005198]	axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; type III intermediate filament [GO:0045098]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15322088, ECO:0000269|PubMed:15446584, ECO:0000269|PubMed:18408015}. Cell projection, axon {ECO:0000250|UniProtKB:P15331}. Perikaryon {ECO:0000250|UniProtKB:P15331}.
P41220	reviewed	RGS2_HUMAN	Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8)	RGS2 G0S8 GIG31	Homo sapiens (Human)	211	FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320). {ECO:0000250|UniProtKB:O08849, ECO:0000269|PubMed:11063746, ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199, ECO:0000269|PubMed:19736320, ECO:0000269|PubMed:28784619, ECO:0000305|PubMed:7643615}.	MISCELLANEOUS: [Isoform 3]: Lacks type V adenylyl cyclase (AC) inhibitory function. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Lacks type V adenylyl cyclase (AC) inhibitory function. {ECO:0000305}.	brown fat cell differentiation [GO:0050873]; cell cycle [GO:0007049]; G protein-coupled receptor signaling pathway [GO:0007186]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process [GO:0140194]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of glycine import across plasma membrane [GO:1900924]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phospholipase activity [GO:0010519]; negative regulation of translation [GO:0017148]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of neuron projection development [GO:0010976]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; relaxation of cardiac muscle [GO:0055119]; relaxation of vascular associated smooth muscle [GO:0060087]; response to amphetamine [GO:0001975]; response to ethanol [GO:0045471]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	adenylate cyclase inhibitor activity [GO:0010855]; beta-tubulin binding [GO:0048487]; calmodulin binding [GO:0005516]; G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; adenylate cyclase inhibitor activity [GO:0010855]; beta-tubulin binding [GO:0048487]; calmodulin binding [GO:0005516]; G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; brown fat cell differentiation [GO:0050873]; cell cycle [GO:0007049]; G protein-coupled receptor signaling pathway [GO:0007186]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process [GO:0140194]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of glycine import across plasma membrane [GO:1900924]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phospholipase activity [GO:0010519]; negative regulation of translation [GO:0017148]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of neuron projection development [GO:0010976]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; relaxation of cardiac muscle [GO:0055119]; relaxation of vascular associated smooth muscle [GO:0060087]; response to amphetamine [GO:0001975]; response to ethanol [GO:0045471]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199, ECO:0000269|PubMed:28784619}. Cytoplasm {ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199}. Nucleus, nucleolus {ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:17901199}. Cytoplasm {ECO:0000269|PubMed:17901199}. Nucleus, nucleolus {ECO:0000269|PubMed:17901199}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:17901199}. Cytoplasm {ECO:0000269|PubMed:17901199}. Nucleus, nucleolus {ECO:0000269|PubMed:17901199}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:17901199}. Mitochondrion {ECO:0000269|PubMed:17901199}.
P41221	reviewed	WNT5A_HUMAN	Protein Wnt-5a	WNT5A	Homo sapiens (Human)	380	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). {ECO:0000250|UniProtKB:P22725, ECO:0000250|UniProtKB:Q27Q52, ECO:0000269|PubMed:15735754, ECO:0000269|PubMed:17426020}.		activation of protein kinase B activity [GO:0032148]; anterior/posterior axis specification, embryo [GO:0008595]; atrial septum development [GO:0003283]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; canonical Wnt signaling pathway [GO:0060070]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cellular response to calcium ion [GO:0071277]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to type II interferon [GO:0071346]; cervix development [GO:0060067]; chemoattraction of serotonergic neuron axon [GO:0036517]; chemorepulsion of dopaminergic neuron axon [GO:0036518]; cochlea morphogenesis [GO:0090103]; convergent extension involved in axis elongation [GO:0060028]; convergent extension involved in organogenesis [GO:0060029]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; epithelial cell migration [GO:0010631]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; epithelial to mesenchymal transition [GO:0001837]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; excitatory synapse assembly [GO:1904861]; face development [GO:0060324]; fibroblast growth factor receptor signaling pathway [GO:0008543]; genitalia development [GO:0048806]; heart looping [GO:0001947]; hematopoietic stem cell proliferation [GO:0071425]; hindgut morphogenesis [GO:0007442]; hypophysis morphogenesis [GO:0048850]; inflammatory response [GO:0006954]; inhibitory synapse assembly [GO:1904862]; JNK cascade [GO:0007254]; keratinocyte differentiation [GO:0030216]; kidney development [GO:0001822]; lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599]; lens development in camera-type eye [GO:0002088]; lung development [GO:0030324]; macrophage derived foam cell differentiation [GO:0010742]; male gonad development [GO:0008584]; mammary gland branching involved in thelarche [GO:0060744]; meiotic nuclear division [GO:0140013]; melanocyte proliferation [GO:0097325]; mesenchymal cell proliferation [GO:0010463]; mesenchymal-epithelial cell signaling [GO:0060638]; mesodermal to mesenchymal transition involved in gastrulation [GO:0060809]; midgut development [GO:0007494]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell proliferation in midbrain [GO:1904934]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of melanin biosynthetic process [GO:0048022]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of synapse assembly [GO:0051964]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; non-canonical Wnt signaling pathway via JNK cascade [GO:0038031]; notochord morphogenesis [GO:0048570]; olfactory bulb interneuron development [GO:0021891]; optic cup formation involved in camera-type eye development [GO:0003408]; paraxial mesoderm formation [GO:0048341]; planar cell polarity pathway involved in axis elongation [GO:0003402]; planar cell polarity pathway involved in axon guidance [GO:1904938]; planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:0061350]; planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:0061349]; planar cell polarity pathway involved in gastrula mediolateral intercalation [GO:0060775]; planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation [GO:1904955]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; planar cell polarity pathway involved in outflow tract morphogenesis [GO:0061347]; planar cell polarity pathway involved in pericardium morphogenesis [GO:0061354]; planar cell polarity pathway involved in ventricular septum morphogenesis [GO:0061348]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endocytosis [GO:0045807]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [GO:0090082]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of ossification [GO:0045778]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of timing of anagen [GO:0051885]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of type II interferon production [GO:0032729]; post-anal tail morphogenesis [GO:0036342]; postsynapse assembly [GO:0099068]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; presynapse assembly [GO:0099054]; primary heart field specification [GO:0003138]; primitive streak formation [GO:0090009]; protein localization [GO:0008104]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of inflammatory response [GO:0050727]; regulation of postsynapse organization [GO:0099175]; regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566]; regulation of synapse organization [GO:0050807]; response to organic substance [GO:0010033]; secondary heart field specification [GO:0003139]; secondary palate development [GO:0062009]; somitogenesis [GO:0001756]; thymocyte apoptotic process [GO:0070242]; type B pancreatic cell development [GO:0003323]; urinary bladder development [GO:0060157]; uterus development [GO:0060065]; vagina development [GO:0060068]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing [GO:0042060]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685]	chemoattractant activity involved in axon guidance [GO:1902379]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase-like orphan receptor binding [GO:0005115]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685]; chemoattractant activity involved in axon guidance [GO:1902379]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase-like orphan receptor binding [GO:0005115]; activation of protein kinase B activity [GO:0032148]; anterior/posterior axis specification, embryo [GO:0008595]; atrial septum development [GO:0003283]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; canonical Wnt signaling pathway [GO:0060070]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cellular response to calcium ion [GO:0071277]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to type II interferon [GO:0071346]; cervix development [GO:0060067]; chemoattraction of serotonergic neuron axon [GO:0036517]; chemorepulsion of dopaminergic neuron axon [GO:0036518]; cochlea morphogenesis [GO:0090103]; convergent extension involved in axis elongation [GO:0060028]; convergent extension involved in organogenesis [GO:0060029]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; epithelial cell migration [GO:0010631]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; epithelial to mesenchymal transition [GO:0001837]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; excitatory synapse assembly [GO:1904861]; face development [GO:0060324]; fibroblast growth factor receptor signaling pathway [GO:0008543]; genitalia development [GO:0048806]; heart looping [GO:0001947]; hematopoietic stem cell proliferation [GO:0071425]; hindgut morphogenesis [GO:0007442]; hypophysis morphogenesis [GO:0048850]; inflammatory response [GO:0006954]; inhibitory synapse assembly [GO:1904862]; JNK cascade [GO:0007254]; keratinocyte differentiation [GO:0030216]; kidney development [GO:0001822]; lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599]; lens development in camera-type eye [GO:0002088]; lung development [GO:0030324]; macrophage derived foam cell differentiation [GO:0010742]; male gonad development [GO:0008584]; mammary gland branching involved in thelarche [GO:0060744]; meiotic nuclear division [GO:0140013]; melanocyte proliferation [GO:0097325]; mesenchymal cell proliferation [GO:0010463]; mesenchymal-epithelial cell signaling [GO:0060638]; mesodermal to mesenchymal transition involved in gastrulation [GO:0060809]; midgut development [GO:0007494]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell proliferation in midbrain [GO:1904934]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of melanin biosynthetic process [GO:0048022]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of synapse assembly [GO:0051964]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; non-canonical Wnt signaling pathway via JNK cascade [GO:0038031]; notochord morphogenesis [GO:0048570]; olfactory bulb interneuron development [GO:0021891]; optic cup formation involved in camera-type eye development [GO:0003408]; paraxial mesoderm formation [GO:0048341]; planar cell polarity pathway involved in axis elongation [GO:0003402]; planar cell polarity pathway involved in axon guidance [GO:1904938]; planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:0061350]; planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:0061349]; planar cell polarity pathway involved in gastrula mediolateral intercalation [GO:0060775]; planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation [GO:1904955]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; planar cell polarity pathway involved in outflow tract morphogenesis [GO:0061347]; planar cell polarity pathway involved in pericardium morphogenesis [GO:0061354]; planar cell polarity pathway involved in ventricular septum morphogenesis [GO:0061348]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endocytosis [GO:0045807]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [GO:0090082]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of ossification [GO:0045778]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of timing of anagen [GO:0051885]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of type II interferon production [GO:0032729]; post-anal tail morphogenesis [GO:0036342]; postsynapse assembly [GO:0099068]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; presynapse assembly [GO:0099054]; primary heart field specification [GO:0003138]; primitive streak formation [GO:0090009]; protein localization [GO:0008104]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of inflammatory response [GO:0050727]; regulation of postsynapse organization [GO:0099175]; regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566]; regulation of synapse organization [GO:0050807]; response to organic substance [GO:0010033]; secondary heart field specification [GO:0003139]; secondary palate development [GO:0062009]; somitogenesis [GO:0001756]; thymocyte apoptotic process [GO:0070242]; type B pancreatic cell development [GO:0003323]; urinary bladder development [GO:0060157]; uterus development [GO:0060065]; vagina development [GO:0060068]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
P41222	reviewed	PTGDS_HUMAN	Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (L-PGDS) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2)	PTGDS PDS	Homo sapiens (Human)	190	FUNCTION: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation (PubMed:20667974). Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:20667974, PubMed:9475419). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). {ECO:0000250|UniProtKB:O09114, ECO:0000269|PubMed:20667974, ECO:0000269|PubMed:9475419}.	MISCELLANEOUS: It has been proposed that the urinary and serum levels may provide a sensitive indicator of renal damage in diabetes mellitus and hypertension. Elevated levels in the coronary circulation may also be associated with angina. Changes in charge and molecular weight microheterogeneity, due to modification of the N-linked oligosaccharides, may be associated with neurodegenerative disease and multiple sclerosis. Detected in meningioma but not in other brain tumors and may be considered a specific cell marker for meningioma. Expression levels in amniotic fluid are altered in abnormal pregnancies. Levels are lower in pregnancies with trisomic fetuses and fetuses with renal abnormalities.	cyclooxygenase pathway [GO:0019371]; gene expression [GO:0010467]; mast cell degranulation [GO:0043303]; negative regulation of male germ cell proliferation [GO:2000255]; prostaglandin biosynthetic process [GO:0001516]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; response to glucocorticoid [GO:0051384]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum [GO:0005791]	fatty acid binding [GO:0005504]; prostaglandin-D synthase activity [GO:0004667]; retinoid binding [GO:0005501]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum [GO:0005791]; fatty acid binding [GO:0005504]; prostaglandin-D synthase activity [GO:0004667]; retinoid binding [GO:0005501]; cyclooxygenase pathway [GO:0019371]; gene expression [GO:0010467]; mast cell degranulation [GO:0043303]; negative regulation of male germ cell proliferation [GO:2000255]; prostaglandin biosynthetic process [GO:0001516]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; response to glucocorticoid [GO:0051384]	SUBCELLULAR LOCATION: Rough endoplasmic reticulum {ECO:0000269|PubMed:9065498}. Nucleus membrane {ECO:0000269|PubMed:9065498}. Golgi apparatus {ECO:0000269|PubMed:9065498}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9065498}. Secreted {ECO:0000269|PubMed:9065498}. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
P41223	reviewed	BUD31_HUMAN	Protein BUD31 homolog (Protein EDG-2) (Protein G10 homolog)	BUD31 EDG2	Homo sapiens (Human)	144	FUNCTION: Involved in the pre-mRNA splicing process (PubMed:28502770, PubMed:28076346). May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity (PubMed:25091737). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:25091737}.		mRNA splicing, via spliceosome [GO:0000398]; positive regulation of androgen receptor activity [GO:2000825]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]	nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of androgen receptor activity [GO:2000825]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25091737, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. Note=Detected in chromatin at the promoter of AR target genes. {ECO:0000305|PubMed:25091737}.
P41225	reviewed	SOX3_HUMAN	Transcription factor SOX-3	SOX3	Homo sapiens (Human)	446	FUNCTION: Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). {ECO:0000250, ECO:0000269|PubMed:21183788}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; face development [GO:0060324]; hypothalamus development [GO:0021854]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pituitary gland development [GO:0021983]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; sex determination [GO:0007530]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; face development [GO:0060324]; hypothalamus development [GO:0021854]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pituitary gland development [GO:0021983]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; sex determination [GO:0007530]	SUBCELLULAR LOCATION: Nucleus.
P41226	reviewed	UBA7_HUMAN	Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (D8) (Ubiquitin-activating enzyme E1 homolog)	UBA7 UBE1L UBE2	Homo sapiens (Human)	1012	FUNCTION: Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269|PubMed:16254333, ECO:0000269|PubMed:20133869}.	MISCELLANEOUS: There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.	DNA damage response [GO:0006974]; innate immune response [GO:0045087]; ISG15-protein conjugation [GO:0032020]; modification-dependent protein catabolic process [GO:0019941]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; ISG15 activating enzyme activity [GO:0019782]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ISG15 activating enzyme activity [GO:0019782]; ubiquitin-protein transferase activity [GO:0004842]; DNA damage response [GO:0006974]; innate immune response [GO:0045087]; ISG15-protein conjugation [GO:0032020]; modification-dependent protein catabolic process [GO:0019941]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]	
P41227	reviewed	NAA10_HUMAN	N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10)	NAA10 ARD1 ARD1A TE2	Homo sapiens (Human)	235	FUNCTION: Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052, PubMed:29754825, PubMed:20154145, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}.		chromosome organization [GO:0051276]; internal protein amino acid acetylation [GO:0006475]; N-terminal protein amino acid acetylation [GO:0006474]; negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric [GO:2000719]; protein acetylation [GO:0006473]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; NatA complex [GO:0031415]; nucleolus [GO:0005730]; nucleus [GO:0005634]	N-acetyltransferase activity [GO:0008080]; peptide alpha-N-acetyltransferase activity [GO:0004596]; peptide-glutamate-alpha-N-acetyltransferase activity [GO:1990190]; peptide-serine-alpha-N-acetyltransferase activity [GO:1990189]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; NatA complex [GO:0031415]; nucleolus [GO:0005730]; nucleus [GO:0005634]; N-acetyltransferase activity [GO:0008080]; peptide alpha-N-acetyltransferase activity [GO:0004596]; peptide-glutamate-alpha-N-acetyltransferase activity [GO:1990190]; peptide-serine-alpha-N-acetyltransferase activity [GO:1990189]; chromosome organization [GO:0051276]; internal protein amino acid acetylation [GO:0006475]; N-terminal protein amino acid acetylation [GO:0006474]; negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric [GO:2000719]; protein acetylation [GO:0006473]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:25732826}. Nucleus {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:25732826}. Note=Also present in the free cytosolic and cytoskeleton-bound polysomes. {ECO:0000269|PubMed:15496142}.
P41229	reviewed	KDM5C_HUMAN	Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C)	KDM5C DXS1272E JARID1C SMCX XE169	Homo sapiens (Human)	1560	FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:28262558}.	MISCELLANEOUS: Escapes X-inactivation.	chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; response to toxic substance [GO:0009636]; rhythmic process [GO:0048511]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; zinc ion binding [GO:0008270]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; response to toxic substance [GO:0009636]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:17468742}.
P41231	reviewed	P2RY2_HUMAN	P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor)	P2RY2 P2RU1	Homo sapiens (Human)	377	FUNCTION: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.		blood vessel diameter maintenance [GO:0097746]; cellular response to ATP [GO:0071318]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular monoatomic ion homeostasis [GO:0006873]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of mucus secretion [GO:0070257]	plasma membrane [GO:0005886]	A1 adenosine receptor binding [GO:0031686]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled UTP receptor activity [GO:0045030]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; A1 adenosine receptor binding [GO:0031686]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled UTP receptor activity [GO:0045030]; signaling receptor activity [GO:0038023]; blood vessel diameter maintenance [GO:0097746]; cellular response to ATP [GO:0071318]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular monoatomic ion homeostasis [GO:0006873]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of mucus secretion [GO:0070257]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P41235	reviewed	HNF4A_HUMAN	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)	HNF4A HNF4 NR2A1 TCF14	Homo sapiens (Human)	474	FUNCTION: Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}.	MISCELLANEOUS: Binds fatty acids.; MISCELLANEOUS: [Isoform HNF4-Alpha-1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform HNF4-Alpha-2]: Produced by alternative splicing of isoform HNF4-Alpha-1. {ECO:0000305}.; MISCELLANEOUS: [Isoform HNF4-Alpha-3]: Produced by alternative splicing of isoform HNF4-Alpha-1. {ECO:0000305}.; MISCELLANEOUS: [Isoform HNF4-Alpha-4]: Produced by alternative splicing of isoform HNF4-Alpha-1. {ECO:0000305}.; MISCELLANEOUS: [Isoform HNF4-Alpha-7]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform HNF4-Alpha-8]: Produced by alternative splicing of isoform HNF4-Alpha-7. {ECO:0000305}.; MISCELLANEOUS: [Isoform HNF4-Alpha-9]: Produced by alternative splicing of isoform HNF4-Alpha-7. {ECO:0000305}.	anatomical structure development [GO:0048856]; blood coagulation [GO:0007596]; cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; glucose homeostasis [GO:0042593]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; ornithine metabolic process [GO:0006591]; phospholipid homeostasis [GO:0055091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of gastrulation [GO:0010470]; regulation of growth hormone receptor signaling pathway [GO:0060398]; regulation of insulin secretion [GO:0050796]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]; rhythmic process [GO:0048511]; sex differentiation [GO:0007548]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein signal transduction [GO:0060395]; transcription by RNA polymerase II [GO:0006366]; triglyceride homeostasis [GO:0070328]; xenobiotic metabolic process [GO:0006805]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; fatty acid binding [GO:0005504]; nuclear receptor activity [GO:0004879]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor binding [GO:0005102]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; fatty acid binding [GO:0005504]; nuclear receptor activity [GO:0004879]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor binding [GO:0005102]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; anatomical structure development [GO:0048856]; blood coagulation [GO:0007596]; cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; glucose homeostasis [GO:0042593]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; ornithine metabolic process [GO:0006591]; phospholipid homeostasis [GO:0055091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of gastrulation [GO:0010470]; regulation of growth hormone receptor signaling pathway [GO:0060398]; regulation of insulin secretion [GO:0050796]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]; rhythmic process [GO:0048511]; sex differentiation [GO:0007548]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein signal transduction [GO:0060395]; transcription by RNA polymerase II [GO:0006366]; triglyceride homeostasis [GO:0070328]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Nucleus.
P41236	reviewed	IPP2_HUMAN	Protein phosphatase inhibitor 2 (IPP-2)	PPP1R2 IPP2	Homo sapiens (Human)	205	FUNCTION: Inhibitor of protein-phosphatase 1.		generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; regulation of signal transduction [GO:0009966]		molecular function inhibitor activity [GO:0140678]; protein phosphatase inhibitor activity [GO:0004864]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]	molecular function inhibitor activity [GO:0140678]; protein phosphatase inhibitor activity [GO:0004864]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; regulation of signal transduction [GO:0009966]	
P41238	reviewed	ABEC1_HUMAN	C->U-editing enzyme APOBEC-1 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic subunit 1) (APO1) (APOBEC-1) (Apolipoprotein B mRNA-editing enzyme 1) (EC 3.5.4.36) (HEPR) (mRNA(cytosine(6666)) deaminase 1)	APOBEC1	Homo sapiens (Human)	236	FUNCTION: Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs (PubMed:30844405). Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA (PubMed:24916387). Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA (PubMed:11727199). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity). {ECO:0000250|UniProtKB:P51908, ECO:0000269|PubMed:11727199, ECO:0000269|PubMed:24916387, ECO:0000269|PubMed:30844405}.		cytidine to uridine editing [GO:0016554]; DNA demethylation [GO:0080111]; establishment of localization in cell [GO:0051649]; lipid metabolic process [GO:0006629]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein transport [GO:0042953]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of DNA methylation-dependent heterochromatin formation [GO:0090310]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; negative regulation of triglyceride metabolic process [GO:0090209]; positive regulation of DNA demethylation [GO:1901537]; regulation of cell population proliferation [GO:0042127]; response to gamma radiation [GO:0010332]; triglyceride metabolic process [GO:0006641]	apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	catalytic activity, acting on RNA [GO:0140098]; cytidine deaminase activity [GO:0004126]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; catalytic activity, acting on RNA [GO:0140098]; cytidine deaminase activity [GO:0004126]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; cytidine to uridine editing [GO:0016554]; DNA demethylation [GO:0080111]; establishment of localization in cell [GO:0051649]; lipid metabolic process [GO:0006629]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein transport [GO:0042953]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of DNA methylation-dependent heterochromatin formation [GO:0090310]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; negative regulation of triglyceride metabolic process [GO:0090209]; positive regulation of DNA demethylation [GO:1901537]; regulation of cell population proliferation [GO:0042127]; response to gamma radiation [GO:0010332]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22580899}. Nucleus {ECO:0000269|PubMed:24916387}.
P41240	reviewed	CSK_HUMAN	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)	CSK	Homo sapiens (Human)	450	FUNCTION: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}.		adaptive immune response [GO:0002250]; adherens junction organization [GO:0034332]; cellular response to peptide hormone stimulus [GO:0071375]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of phagocytosis [GO:0050765]; oligodendrocyte differentiation [GO:0048709]; protein phosphorylation [GO:0006468]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; proline-rich region binding [GO:0070064]; protein kinase A catalytic subunit binding [GO:0034236]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase binding [GO:1990782]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; proline-rich region binding [GO:0070064]; protein kinase A catalytic subunit binding [GO:0034236]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase binding [GO:1990782]; adaptive immune response [GO:0002250]; adherens junction organization [GO:0034332]; cellular response to peptide hormone stimulus [GO:0071375]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of phagocytosis [GO:0050765]; oligodendrocyte differentiation [GO:0048709]; protein phosphorylation [GO:0006468]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}.
P41247	reviewed	PLPL4_HUMAN	Patatin-like phospholipase domain-containing protein 4 (EC 3.1.1.3) (Calcium-independent phospholipase A2-eta) (iPLA2-eta) (EC 3.1.1.4) (Protein GS2)	PNPLA4 DXS1283E GS2	Homo sapiens (Human)	253	FUNCTION: Has abundant triacylglycerol lipase activity (PubMed:15364929, PubMed:16150821, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Additionally possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17603008). {ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:17603008}.		lipid homeostasis [GO:0055088]; triglyceride catabolic process [GO:0019433]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrion [GO:0005739]	acylglycerol O-acyltransferase activity [GO:0016411]; all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; diolein transacylation activity [GO:0051265]; mono-olein transacylation activity [GO:0051264]; phospholipase A2 activity [GO:0004623]; retinyl-palmitate esterase activity [GO:0050253]; triglyceride lipase activity [GO:0004806]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrion [GO:0005739]; acylglycerol O-acyltransferase activity [GO:0016411]; all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; diolein transacylation activity [GO:0051265]; mono-olein transacylation activity [GO:0051264]; phospholipase A2 activity [GO:0004623]; retinyl-palmitate esterase activity [GO:0050253]; triglyceride lipase activity [GO:0004806]; lipid homeostasis [GO:0055088]; triglyceride catabolic process [GO:0019433]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:26741492}.
P41250	reviewed	GARS_HUMAN	Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1)	GARS1 GARS	Homo sapiens (Human)	739	FUNCTION: Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:28675565, PubMed:24898252). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}.	MISCELLANEOUS: Human GlyRS uses direct ATP condensation to synthesize Ap4A, a unique amino acid-independent mechanism, in contrast to the classical amino acid-dependent mechanism for synthesis of Ap4A by a tRNA synthetase, that involves the generation of an enzyme-bound aminoacyl-AMP which is then attacked by ATP to form Ap4A. {ECO:0000269|PubMed:19710017}.; MISCELLANEOUS: [Isoform 2]: The isoform 2 translation is regulated by an Internal Ribosome Entry Site (IRES) and an upstream Open Reading Frame. Both are important in hindering the synthesis of the mitochondrial GARS and target the translation of the cytosolic enzyme to ER-bound ribosomes. {ECO:0000305|PubMed:26327585}.	diadenosine tetraphosphate biosynthetic process [GO:0015966]; mitochondrial glycyl-tRNA aminoacylation [GO:0070150]; tRNA aminoacylation for protein translation [GO:0006418]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; secretory granule [GO:0030141]	ATP binding [GO:0005524]; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity [GO:0004081]; glycine-tRNA ligase activity [GO:0004820]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; transferase activity [GO:0016740]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; secretory granule [GO:0030141]; ATP binding [GO:0005524]; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity [GO:0004081]; glycine-tRNA ligase activity [GO:0004820]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; transferase activity [GO:0016740]; diadenosine tetraphosphate biosynthetic process [GO:0015966]; mitochondrial glycyl-tRNA aminoacylation [GO:0070150]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17035524}. Cell projection, axon {ECO:0000269|PubMed:17035524}. Secreted {ECO:0000250|UniProtKB:Q9CZD3}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:Q9CZD3}. Note=In transfected COS7 cells, not detected in mitochondria, nor in Golgi apparatus (PubMed:17035524). Secreted by motor neuron, possibly through the exosome pathway (By similarity). {ECO:0000250|UniProtKB:Q9CZD3, ECO:0000269|PubMed:17035524}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:17529987, ECO:0000269|PubMed:26327585}. Cytoplasm {ECO:0000269|PubMed:26327585}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17529987, ECO:0000269|PubMed:26327585}. Cell projection, axon {ECO:0000269|PubMed:25168514}.
P41252	reviewed	SYIC_HUMAN	Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)	IARS1 IARS	Homo sapiens (Human)	1262	FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}.		isoleucyl-tRNA aminoacylation [GO:0006428]; osteoblast differentiation [GO:0001649]; tRNA aminoacylation for protein translation [GO:0006418]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; GTPase binding [GO:0051020]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; GTPase binding [GO:0051020]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049]; isoleucyl-tRNA aminoacylation [GO:0006428]; osteoblast differentiation [GO:0001649]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27426735, ECO:0000269|PubMed:7721108}. Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}.
P41271	reviewed	NBL1_HUMAN	Neuroblastoma suppressor of tumorigenicity 1 (DAN domain family member 1) (Protein N03) (Zinc finger protein DAN)	NBL1 DAN DAND1	Homo sapiens (Human)	181	FUNCTION: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.		animal organ morphogenesis [GO:0009887]; determination of dorsal identity [GO:0048263]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of monocyte chemotaxis [GO:0090027]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; positive regulation of neuron differentiation [GO:0045666]; sequestering of BMP from receptor via BMP binding [GO:0038098]; sequestering of BMP in extracellular matrix [GO:0035582]	extracellular space [GO:0005615]	BMP binding [GO:0036122]; identical protein binding [GO:0042802]; morphogen activity [GO:0016015]; receptor ligand activity [GO:0048018]	extracellular space [GO:0005615]; BMP binding [GO:0036122]; identical protein binding [GO:0042802]; morphogen activity [GO:0016015]; receptor ligand activity [GO:0048018]; animal organ morphogenesis [GO:0009887]; determination of dorsal identity [GO:0048263]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of monocyte chemotaxis [GO:0090027]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; positive regulation of neuron differentiation [GO:0045666]; sequestering of BMP from receptor via BMP binding [GO:0038098]; sequestering of BMP in extracellular matrix [GO:0035582]	SUBCELLULAR LOCATION: Secreted.
P41273	reviewed	TNFL9_HUMAN	Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL)	TNFSF9	Homo sapiens (Human)	254	FUNCTION: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. {ECO:0000269|PubMed:20032458}.		cell-cell signaling [GO:0007267]; immune response [GO:0006955]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cytotoxic T cell differentiation [GO:0045585]; regulation of apoptotic process [GO:0042981]; regulation of T cell proliferation [GO:0042129]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]; cell-cell signaling [GO:0007267]; immune response [GO:0006955]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cytotoxic T cell differentiation [GO:0045585]; regulation of apoptotic process [GO:0042981]; regulation of T cell proliferation [GO:0042129]	SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
P41279	reviewed	M3K8_HUMAN	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)	MAP3K8 COT ESTF	Homo sapiens (Human)	467	FUNCTION: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. {ECO:0000269|PubMed:11342626, ECO:0000269|PubMed:12667451, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:16371247, ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:19001140, ECO:0000269|PubMed:19808894}.	MISCELLANEOUS: Can be converted to an oncogenic protein by proviral activation, leading to a C-terminally truncated protein with transforming activity.	cell cycle [GO:0007049]; protein phosphorylation [GO:0006468]; T cell costimulation [GO:0031295]	cytosol [GO:0005829]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell cycle [GO:0007049]; protein phosphorylation [GO:0006468]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:8226782}.
P41439	reviewed	FOLR3_HUMAN	Folate receptor gamma (FR-gamma) (Folate receptor 3)	FOLR3	Homo sapiens (Human)	245	FUNCTION: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Variant in position: 150:MSAHPTWGPGSGRSTRAGAKSAF->ECSPNLGPWIRQVNQSWRKERILNVPLCKEDCERW WEDCRTSYTCKSNWHKGWNWTSGINECPAGALCSTFESYFPTPAALCEGLWSHSFKVSNYSRG. {ECO:0000305}.	cell adhesion [GO:0007155]; folic acid transport [GO:0015884]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; sperm-egg recognition [GO:0035036]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	folic acid binding [GO:0005542]; signaling receptor activity [GO:0038023]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; folic acid binding [GO:0005542]; signaling receptor activity [GO:0038023]; cell adhesion [GO:0007155]; folic acid transport [GO:0015884]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; sperm-egg recognition [GO:0035036]	SUBCELLULAR LOCATION: Secreted.
P41440	reviewed	S19A1_HUMAN	Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1)	SLC19A1 FLOT1 RFC1	Homo sapiens (Human)	591	FUNCTION: Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:7826387, PubMed:9041240, PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31511694, PubMed:31126740, PubMed:32276275). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (PubMed:22554803, PubMed:31511694, PubMed:31126740). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803). Also able to mediate the import of antifolate drug methotrexate (PubMed:7615551, PubMed:7641195, PubMed:9767079, PubMed:22554803). Also acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses (PubMed:31511694, PubMed:31126740). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803). {ECO:0000269|PubMed:10787414, ECO:0000269|PubMed:14609557, ECO:0000269|PubMed:15337749, ECO:0000269|PubMed:16115875, ECO:0000269|PubMed:22554803, ECO:0000269|PubMed:31126740, ECO:0000269|PubMed:31511694, ECO:0000269|PubMed:32276275, ECO:0000269|PubMed:7615551, ECO:0000269|PubMed:7641195, ECO:0000269|PubMed:7826387, ECO:0000269|PubMed:9041240, ECO:0000269|PubMed:9767079}.		cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; female pregnancy [GO:0007565]; folate import across plasma membrane [GO:1904447]; folate transmembrane transport [GO:0098838]; folic acid metabolic process [GO:0046655]; folic acid transport [GO:0015884]; methotrexate transport [GO:0051958]; organic anion transport [GO:0015711]; transport across blood-brain barrier [GO:0150104]; xenobiotic transmembrane transport [GO:0006855]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]	2',3'-cyclic GMP-AMP binding [GO:0061507]; antiporter activity [GO:0015297]; cyclic-GMP-AMP transmembrane transporter activity [GO:0140360]; folate:monoatomic anion antiporter activity [GO:0008518]; folic acid binding [GO:0005542]; folic acid transmembrane transporter activity [GO:0008517]; methotrexate transmembrane transporter activity [GO:0015350]; organic anion transmembrane transporter activity [GO:0008514]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]; 2',3'-cyclic GMP-AMP binding [GO:0061507]; antiporter activity [GO:0015297]; cyclic-GMP-AMP transmembrane transporter activity [GO:0140360]; folate:monoatomic anion antiporter activity [GO:0008518]; folic acid binding [GO:0005542]; folic acid transmembrane transporter activity [GO:0008517]; methotrexate transmembrane transporter activity [GO:0015350]; organic anion transmembrane transporter activity [GO:0008514]; xenobiotic transmembrane transporter activity [GO:0042910]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; female pregnancy [GO:0007565]; folate import across plasma membrane [GO:1904447]; folate transmembrane transport [GO:0098838]; folic acid metabolic process [GO:0046655]; folic acid transport [GO:0015884]; methotrexate transport [GO:0051958]; organic anion transport [GO:0015711]; transport across blood-brain barrier [GO:0150104]; xenobiotic transmembrane transport [GO:0006855]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10347183, ECO:0000269|PubMed:10787414, ECO:0000269|PubMed:15337749, ECO:0000269|PubMed:16115875, ECO:0000269|PubMed:9767079}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:10787414}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:10787414}; Multi-pass membrane protein {ECO:0000255}.
P41567	reviewed	EIF1_HUMAN	Eukaryotic translation initiation factor 1 (eIF1) (A121) (Protein translation factor SUI1 homolog) (Sui1iso1)	EIF1 SUI1	Homo sapiens (Human)	113	FUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:9732867, PubMed:12435632, PubMed:14600024). Together with eIF1A (EIF1AX), EIF1 facilitates scanning and is essential for start codon recognition on the basis of AUG nucleotide context and location relative to the 5'-cap (PubMed:9732867, PubMed:12435632, PubMed:14600024). Participates to initiation codon selection by influencing the conformation of the 40S ribosomal subunit and the positions of bound mRNA and initiator tRNA; this is possible after its binding to the interface surface of the platform of the 40S ribosomal subunit close to the P-site (PubMed:14600024). Together with eIF1A (EIF1AX), also regulates the opening and closing of the mRNA binding channel, which ensures mRNA recruitment, scanning and the fidelity of initiation codon selection (PubMed:9732867). Continuously monitors and protects against premature and partial base-pairing of codons in the 5'-UTR with the anticodon of initiator tRNA (PubMed:9732867, PubMed:12435632). Together with eIF1A (EIF1AX), acts for ribosomal scanning, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes (PubMed:9732867). Interacts with EIF4G1, which in a mutual exclusive interaction associates either with EIF1 or with EIF4E on a common binding site (PubMed:29987188). EIF4G1-EIF1 complex promotes ribosome scanning (on both short and long 5'UTR), leaky scanning (on short 5'UTR) which is the bypass of the initial start codon, and discrimination against cap-proximal AUG (PubMed:29987188). Is probably maintained within the 43S PIC in open conformation thanks to eIF1A-EIF5 interaction (PubMed:24319994). Once the correct start codon is reached, EIF1 is physically excluded from the decoding site, shifting the PIC into the closed conformation and arresting it at the start codon (PubMed:22813744). {ECO:0000269|PubMed:12435632, ECO:0000269|PubMed:14600024, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:29987188, ECO:0000269|PubMed:9732867}.		dosage compensation by inactivation of X chromosome [GO:0009048]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; multi-eIF complex [GO:0043614]; nucleus [GO:0005634]	ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; multi-eIF complex [GO:0043614]; nucleus [GO:0005634]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; dosage compensation by inactivation of X chromosome [GO:0009048]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P41586	reviewed	PACR_HUMAN	Pituitary adenylate cyclase-activating polypeptide type I receptor (PACAP type I receptor) (PACAP-R-1) (PACAP-R1)	ADCYAP1R1	Homo sapiens (Human)	468	FUNCTION: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cAMP-mediated signaling [GO:0019933]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; development of primary female sexual characteristics [GO:0046545]; multicellular organismal response to stress [GO:0033555]; negative regulation of response to reactive oxygen species [GO:1901032]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]	bicellular tight junction [GO:0005923]; caveola [GO:0005901]; cell surface [GO:0009986]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	adenylate cyclase binding [GO:0008179]; G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]; signaling receptor activity [GO:0038023]; small GTPase binding [GO:0031267]; vasoactive intestinal polypeptide receptor activity [GO:0004999]	bicellular tight junction [GO:0005923]; caveola [GO:0005901]; cell surface [GO:0009986]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; adenylate cyclase binding [GO:0008179]; G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]; signaling receptor activity [GO:0038023]; small GTPase binding [GO:0031267]; vasoactive intestinal polypeptide receptor activity [GO:0004999]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cAMP-mediated signaling [GO:0019933]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; development of primary female sexual characteristics [GO:0046545]; multicellular organismal response to stress [GO:0033555]; negative regulation of response to reactive oxygen species [GO:1901032]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P41587	reviewed	VIPR2_HUMAN	Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2)	VIPR2 VIP2R	Homo sapiens (Human)	438	FUNCTION: This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. {ECO:0000269|PubMed:8926282}.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; negative regulation of smooth muscle cell proliferation [GO:0048662]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; peptide hormone binding [GO:0017046]; vasoactive intestinal polypeptide receptor activity [GO:0004999]	plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; peptide hormone binding [GO:0017046]; vasoactive intestinal polypeptide receptor activity [GO:0004999]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; negative regulation of smooth muscle cell proliferation [GO:0048662]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P41594	reviewed	GRM5_HUMAN	Metabotropic glutamate receptor 5 (mGluR5)	GRM5 GPRC1E MGLUR5	Homo sapiens (Human)	1212	FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}.		calcium-mediated signaling using intracellular calcium source [GO:0035584]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein tyrosine kinase activity [GO:0061098]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of DNA-templated transcription [GO:0006355]; regulation of intracellular calcium activated chloride channel activity [GO:1902938]; regulation of protein phosphorylation [GO:0001932]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of translation [GO:0006417]; regulation of translational elongation [GO:0006448]; synapse organization [GO:0050808]; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553]	astrocyte projection [GO:0097449]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]	A2A adenosine receptor binding [GO:0031687]; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase binding [GO:1990782]	astrocyte projection [GO:0097449]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; A2A adenosine receptor binding [GO:0031687]; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase binding [GO:1990782]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein tyrosine kinase activity [GO:0061098]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of DNA-templated transcription [GO:0006355]; regulation of intracellular calcium activated chloride channel activity [GO:1902938]; regulation of protein phosphorylation [GO:0001932]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of translation [GO:0006417]; regulation of translational elongation [GO:0006448]; synapse organization [GO:0050808]; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}; Multi-pass membrane protein {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}.
P41595	reviewed	5HT2B_HUMAN	5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B)	HTR2B	Homo sapiens (Human)	481	FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538). Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519215, PubMed:28129538). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity). {ECO:0000250|UniProtKB:P30994, ECO:0000250|UniProtKB:Q02152, ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:21179162, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856, ECO:0000269|PubMed:8882600}.	MISCELLANEOUS: Binds lysergic acid diethylamine (LSD) in the orthosteric pocket, but is not the principal LSD receptor in the brain. Bound LSD dissociates extremely slowly, with a residence time of about 46 minutes at 37 degrees Celsius. {ECO:0000269|PubMed:28129538}.	activation of phospholipase C activity [GO:0007202]; behavior [GO:0007610]; calcium-mediated signaling [GO:0019722]; cardiac muscle hypertrophy [GO:0003300]; cellular response to temperature stimulus [GO:0071502]; cGMP-mediated signaling [GO:0019934]; chemical synaptic transmission [GO:0007268]; embryonic morphogenesis [GO:0048598]; ERK1 and ERK2 cascade [GO:0070371]; G protein-coupled receptor internalization [GO:0002031]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; heart morphogenesis [GO:0003007]; intestine smooth muscle contraction [GO:0014827]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of apoptotic process [GO:0043066]; neural crest cell differentiation [GO:0014033]; neural crest cell migration [GO:0001755]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; phosphorylation [GO:0016310]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; protein kinase C signaling [GO:0070528]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of behavior [GO:0050795]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; vasoconstriction [GO:0042310]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; G protein-coupled serotonin receptor complex [GO:0098666]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled serotonin receptor activity [GO:0004993]; G-protein alpha-subunit binding [GO:0001965]; Gq/11-coupled serotonin receptor activity [GO:0001587]; GTPase activator activity [GO:0005096]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; G protein-coupled serotonin receptor complex [GO:0098666]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled serotonin receptor activity [GO:0004993]; G-protein alpha-subunit binding [GO:0001965]; Gq/11-coupled serotonin receptor activity [GO:0001587]; GTPase activator activity [GO:0005096]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; activation of phospholipase C activity [GO:0007202]; behavior [GO:0007610]; calcium-mediated signaling [GO:0019722]; cardiac muscle hypertrophy [GO:0003300]; cellular response to temperature stimulus [GO:0071502]; cGMP-mediated signaling [GO:0019934]; chemical synaptic transmission [GO:0007268]; embryonic morphogenesis [GO:0048598]; ERK1 and ERK2 cascade [GO:0070371]; G protein-coupled receptor internalization [GO:0002031]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; heart morphogenesis [GO:0003007]; intestine smooth muscle contraction [GO:0014827]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of apoptotic process [GO:0043066]; neural crest cell differentiation [GO:0014033]; neural crest cell migration [GO:0001755]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; phosphorylation [GO:0016310]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; protein kinase C signaling [GO:0070528]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of behavior [GO:0050795]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; vasoconstriction [GO:0042310]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856}; Multi-pass membrane protein {ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q02152}.
P41597	reviewed	CCR2_HUMAN	C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192)	CCR2 CMKBR2	Homo sapiens (Human)	374	FUNCTION: Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (PubMed:8146186, PubMed:8048929, PubMed:23408426). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity). {ECO:0000250|UniProtKB:P51683, ECO:0000269|PubMed:23408426, ECO:0000269|PubMed:23938203, ECO:0000269|PubMed:8048929, ECO:0000269|PubMed:8146186, ECO:0000305|PubMed:15995708}.; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:9789057}.	MISCELLANEOUS: [Isoform B]: Mutagenesis of Leu-316 to Thr as well as Phe-320 to Asp decrease interaction with NUP85. {ECO:0000269|PubMed:27926736}.	blood vessel remodeling [GO:0001974]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; cellular homeostasis [GO:0019725]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; dendritic cell chemotaxis [GO:0002407]; hemopoiesis [GO:0030097]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response [GO:0006954]; inflammatory response to wounding [GO:0090594]; intracellular calcium ion homeostasis [GO:0006874]; leukocyte adhesion to vascular endothelial cell [GO:0061756]; macrophage migration [GO:1905517]; monocyte chemotaxis [GO:0002548]; monocyte extravasation [GO:0035696]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of angiogenesis [GO:0016525]; negative regulation of eosinophil degranulation [GO:0043310]; negative regulation of type 2 immune response [GO:0002829]; neutrophil clearance [GO:0097350]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of astrocyte chemotaxis [GO:2000464]; positive regulation of CD8-positive, alpha-beta T cell extravasation [GO:2000451]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of immune complex clearance by monocytes and macrophages [GO:0090265]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of thymocyte migration [GO:2000412]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of inflammatory response [GO:0050727]; regulation of macrophage migration [GO:1905521]; regulation of T cell cytokine production [GO:0002724]; regulation of T cell differentiation [GO:0045580]; regulation of vascular endothelial growth factor production [GO:0010574]; response to wounding [GO:0009611]; sensory perception of pain [GO:0019233]; T-helper 17 cell chemotaxis [GO:0035705]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; fibrillar center [GO:0001650]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; CCR2 chemokine receptor binding [GO:0031727]; chemokine (C-C motif) ligand 12 binding [GO:0035716]; chemokine (C-C motif) ligand 2 binding [GO:0035715]; chemokine (C-C motif) ligand 7 binding [GO:0035717]; chemokine receptor activity [GO:0004950]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; fibrillar center [GO:0001650]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; CCR2 chemokine receptor binding [GO:0031727]; chemokine (C-C motif) ligand 12 binding [GO:0035716]; chemokine (C-C motif) ligand 2 binding [GO:0035715]; chemokine (C-C motif) ligand 7 binding [GO:0035717]; chemokine receptor activity [GO:0004950]; identical protein binding [GO:0042802]; blood vessel remodeling [GO:0001974]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; cellular homeostasis [GO:0019725]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; dendritic cell chemotaxis [GO:0002407]; hemopoiesis [GO:0030097]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response [GO:0006954]; inflammatory response to wounding [GO:0090594]; intracellular calcium ion homeostasis [GO:0006874]; leukocyte adhesion to vascular endothelial cell [GO:0061756]; macrophage migration [GO:1905517]; monocyte chemotaxis [GO:0002548]; monocyte extravasation [GO:0035696]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of angiogenesis [GO:0016525]; negative regulation of eosinophil degranulation [GO:0043310]; negative regulation of type 2 immune response [GO:0002829]; neutrophil clearance [GO:0097350]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of astrocyte chemotaxis [GO:2000464]; positive regulation of CD8-positive, alpha-beta T cell extravasation [GO:2000451]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of immune complex clearance by monocytes and macrophages [GO:0090265]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of thymocyte migration [GO:2000412]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of inflammatory response [GO:0050727]; regulation of macrophage migration [GO:1905521]; regulation of T cell cytokine production [GO:0002724]; regulation of T cell differentiation [GO:0045580]; regulation of vascular endothelial growth factor production [GO:0010574]; response to wounding [GO:0009611]; sensory perception of pain [GO:0019233]; T-helper 17 cell chemotaxis [GO:0035705]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:18587271}; Multi-pass membrane protein {ECO:0000255}. Note=The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. {ECO:0000269|PubMed:15995708}.
P41732	reviewed	TSN7_HUMAN	Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (Membrane component chromosome X surface marker 1) (T-cell acute lymphoblastic leukemia-associated antigen 1) (TALLA-1) (Transmembrane 4 superfamily member 2) (CD antigen CD231)	TSPAN7 A15 DXS1692E MXS1 TM4SF2	Homo sapiens (Human)	249	FUNCTION: May be involved in cell proliferation and cell motility.			plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P41743	reviewed	KPCI_HUMAN	Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)	PRKCI DXS1179E	Homo sapiens (Human)	596	FUNCTION: Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}.		actin filament organization [GO:0007015]; cell migration [GO:0016477]; cell-cell junction organization [GO:0045216]; cellular response to insulin stimulus [GO:0032869]; cytoskeleton organization [GO:0007010]; establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; eye photoreceptor cell development [GO:0042462]; Golgi vesicle budding [GO:0048194]; intracellular signal transduction [GO:0035556]; membrane organization [GO:0061024]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of neuron apoptotic process [GO:0043524]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of glucose import [GO:0046326]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein phosphorylation [GO:0006468]; protein targeting to membrane [GO:0006612]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to interleukin-1 [GO:0070555]; secretion [GO:0046903]; vesicle-mediated transport [GO:0016192]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; brush border [GO:0005903]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160]	ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; brush border [GO:0005903]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; cell-cell junction organization [GO:0045216]; cellular response to insulin stimulus [GO:0032869]; cytoskeleton organization [GO:0007010]; establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; eye photoreceptor cell development [GO:0042462]; Golgi vesicle budding [GO:0048194]; intracellular signal transduction [GO:0035556]; membrane organization [GO:0061024]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of neuron apoptotic process [GO:0043524]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of glucose import [GO:0046326]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein phosphorylation [GO:0006468]; protein targeting to membrane [GO:0006612]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to interleukin-1 [GO:0070555]; secretion [GO:0046903]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:9566925}. Membrane {ECO:0000269|PubMed:16452474}. Endosome {ECO:0000269|PubMed:9566925}. Nucleus {ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:15695176}. Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A. {ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:9566925}.
P41968	reviewed	MC3R_HUMAN	Melanocortin receptor 3 (MC3-R)	MC3R	Homo sapiens (Human)	323	FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. {ECO:0000250|UniProtKB:P33033}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; circadian regulation of gene expression [GO:0032922]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; homoiothermy [GO:0042309]; locomotor rhythm [GO:0045475]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of blood pressure [GO:0008217]; regulation of feeding behavior [GO:0060259]; regulation of heart rate [GO:0002027]; regulation of metabolic process [GO:0019222]; sodium ion homeostasis [GO:0055078]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	melanocortin receptor activity [GO:0004977]; melanocyte-stimulating hormone receptor activity [GO:0004980]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; melanocortin receptor activity [GO:0004977]; melanocyte-stimulating hormone receptor activity [GO:0004980]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; circadian regulation of gene expression [GO:0032922]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; homoiothermy [GO:0042309]; locomotor rhythm [GO:0045475]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of blood pressure [GO:0008217]; regulation of feeding behavior [GO:0060259]; regulation of heart rate [GO:0002027]; regulation of metabolic process [GO:0019222]; sodium ion homeostasis [GO:0055078]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P41970	reviewed	ELK3_HUMAN	ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2)	ELK3 NET SAP2	Homo sapiens (Human)	407	FUNCTION: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.		angiogenesis [GO:0001525]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; wound healing [GO:0042060]	chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; purine-rich negative regulatory element binding [GO:0032422]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; purine-rich negative regulatory element binding [GO:0032422]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; angiogenesis [GO:0001525]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Nucleus.
P42025	reviewed	ACTY_HUMAN	Beta-centractin (Actin-related protein 1B) (ARP1B)	ACTR1B CTRN2	Homo sapiens (Human)	376	FUNCTION: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.			centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; secretory granule lumen [GO:0034774]	ATP binding [GO:0005524]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; secretory granule lumen [GO:0034774]; ATP binding [GO:0005524]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
P42081	reviewed	CD86_HUMAN	T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86)	CD86 CD28LG2	Homo sapiens (Human)	329	FUNCTION: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:P42082, ECO:0000269|PubMed:7527824}.; FUNCTION: [Isoform 2]: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. {ECO:0000269|PubMed:7527824}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus subgroup B. {ECO:0000269|PubMed:16920215}.		activation of phospholipase C activity [GO:0007202]; activation of protein kinase C activity [GO:1990051]; adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; CD40 signaling pathway [GO:0023035]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of lymphotoxin A production [GO:0032761]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]	cell surface [GO:0009986]; centriolar satellite [GO:0034451]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	coreceptor activity [GO:0015026]; receptor ligand activity [GO:0048018]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; centriolar satellite [GO:0034451]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; coreceptor activity [GO:0015026]; receptor ligand activity [GO:0048018]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618]; activation of phospholipase C activity [GO:0007202]; activation of protein kinase C activity [GO:1990051]; adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; CD40 signaling pathway [GO:0023035]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of lymphotoxin A production [GO:0032761]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P42126	reviewed	ECI1_HUMAN	Enoyl-CoA delta isomerase 1, mitochondrial (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase)	ECI1 DCI	Homo sapiens (Human)	302	FUNCTION: Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. {ECO:0000269|PubMed:7818490}.		fatty acid beta-oxidation [GO:0006635]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863]; fatty acid beta-oxidation [GO:0006635]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P23965}.
P42127	reviewed	ASIP_HUMAN	Agouti-signaling protein (ASP) (Agouti switch protein)	ASIP AGTI AGTIL ASP	Homo sapiens (Human)	132	FUNCTION: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. {ECO:0000250|UniProtKB:Q03288}.		adult feeding behavior [GO:0008343]; cell-cell signaling [GO:0007267]; generation of precursor metabolites and energy [GO:0006091]; genomic imprinting [GO:0071514]; hormone-mediated signaling pathway [GO:0009755]; melanin biosynthetic process [GO:0042438]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; positive regulation of melanin biosynthetic process [GO:0048023]; signal transduction [GO:0007165]	extracellular space [GO:0005615]	melanocortin receptor binding [GO:0031779]; neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102]; type 3 melanocortin receptor binding [GO:0031781]; type 4 melanocortin receptor binding [GO:0031782]	extracellular space [GO:0005615]; melanocortin receptor binding [GO:0031779]; neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102]; type 3 melanocortin receptor binding [GO:0031781]; type 4 melanocortin receptor binding [GO:0031782]; adult feeding behavior [GO:0008343]; cell-cell signaling [GO:0007267]; generation of precursor metabolites and energy [GO:0006091]; genomic imprinting [GO:0071514]; hormone-mediated signaling pathway [GO:0009755]; melanin biosynthetic process [GO:0042438]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; positive regulation of melanin biosynthetic process [GO:0048023]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:36536132}.
P42166	reviewed	LAP2A_HUMAN	Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]	TMPO LAP2	Homo sapiens (Human)	694	FUNCTION: May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.			chromatin [GO:0000785]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; DNA binding [GO:0003677]; lamin binding [GO:0005521]	chromatin [GO:0000785]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; DNA binding [GO:0003677]; lamin binding [GO:0005521]	SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus.
P42167	reviewed	LAP2B_HUMAN	Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]	TMPO LAP2	Homo sapiens (Human)	454	FUNCTION: May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; FUNCTION: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.	MISCELLANEOUS: [Isoform Zeta]: Inhibits LAP2beta-mediated repression. {ECO:0000305}.		cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]	DNA binding [GO:0003677]; lamin binding [GO:0005521]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; DNA binding [GO:0003677]; lamin binding [GO:0005521]	SUBCELLULAR LOCATION: Nucleus inner membrane; Single-pass type II membrane protein. Note=Tightly associated with the nuclear lamina.; SUBCELLULAR LOCATION: [Isoform Zeta]: Cytoplasm {ECO:0000269|PubMed:18403046}.
P42224	reviewed	STAT1_HUMAN	Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)	STAT1	Homo sapiens (Human)	750	FUNCTION: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:9724754, PubMed:12855578, PubMed:12764129, PubMed:15322115, PubMed:34508746, PubMed:35568036, PubMed:23940278). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426, PubMed:35568036). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state (PubMed:28753426, PubMed:35568036). In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state (PubMed:8156998). Becomes activated in response to KITLG/SCF and KIT signaling (PubMed:15526160). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:19088846). Involved in food tolerance in small intestine: associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA, inducing type 1 regulatory T (Tr1) cells in upper small intestine (By similarity). {ECO:0000250|UniProtKB:P42225, ECO:0000269|PubMed:12764129, ECO:0000269|PubMed:12855578, ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:23940278, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426, ECO:0000269|PubMed:34508746, ECO:0000269|PubMed:35568036, ECO:0000269|PubMed:8156998, ECO:0000269|PubMed:9724754, ECO:0000303|PubMed:15526160}.		blood circulation [GO:0008015]; cellular response to insulin stimulus [GO:0032869]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; cellular response to type II interferon [GO:0071346]; defense response [GO:0006952]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-9-mediated signaling pathway [GO:0038113]; macrophage derived foam cell differentiation [GO:0010742]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; negative regulation by virus of viral protein levels in host cell [GO:0046725]; negative regulation of angiogenesis [GO:0016525]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003340]; negative regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; renal tubule development [GO:0061326]; response to cAMP [GO:0051591]; response to cytokine [GO:0034097]; response to hydrogen peroxide [GO:0042542]; response to interferon-beta [GO:0035456]; response to mechanical stimulus [GO:0009612]; response to nutrient [GO:0007584]; response to peptide hormone [GO:0043434]; response to type II interferon [GO:0034341]; response to xenobiotic stimulus [GO:0009410]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]	axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; ISGF3 complex [GO:0070721]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]	cadherin binding [GO:0045296]; CCR5 chemokine receptor binding [GO:0031730]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; histone acetyltransferase binding [GO:0035035]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin-like protein ligase binding [GO:0044389]	axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; ISGF3 complex [GO:0070721]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; cadherin binding [GO:0045296]; CCR5 chemokine receptor binding [GO:0031730]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; histone acetyltransferase binding [GO:0035035]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin-like protein ligase binding [GO:0044389]; blood circulation [GO:0008015]; cellular response to insulin stimulus [GO:0032869]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; cellular response to type II interferon [GO:0071346]; defense response [GO:0006952]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-9-mediated signaling pathway [GO:0038113]; macrophage derived foam cell differentiation [GO:0010742]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; negative regulation by virus of viral protein levels in host cell [GO:0046725]; negative regulation of angiogenesis [GO:0016525]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003340]; negative regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; renal tubule development [GO:0061326]; response to cAMP [GO:0051591]; response to cytokine [GO:0034097]; response to hydrogen peroxide [GO:0042542]; response to interferon-beta [GO:0035456]; response to mechanical stimulus [GO:0009612]; response to nutrient [GO:0007584]; response to peptide hormone [GO:0043434]; response to type II interferon [GO:0034341]; response to xenobiotic stimulus [GO:0009410]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:27796300, ECO:0000269|PubMed:28753426}. Nucleus {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426}. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4 (PubMed:15322115). Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus (PubMed:28753426). Translocates into the nucleus in response to interferon-beta stimulation (PubMed:26479788). {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426}.
P42226	reviewed	STAT6_HUMAN	Signal transducer and activator of transcription 6 (IL-4 Stat)	STAT6	Homo sapiens (Human)	847	FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269|PubMed:17210636}.		cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive nitrogen species [GO:1902170]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-4-mediated signaling pathway [GO:0035771]; isotype switching to IgE isotypes [GO:0048289]; mammary gland epithelial cell proliferation [GO:0033598]; mammary gland morphogenesis [GO:0060443]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of isotype switching to IgE isotypes [GO:0048295]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell population proliferation [GO:0042127]; regulation of mast cell proliferation [GO:0070666]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]; T-helper 1 cell lineage commitment [GO:0002296]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator binding [GO:0001223]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator binding [GO:0001223]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive nitrogen species [GO:1902170]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-4-mediated signaling pathway [GO:0035771]; isotype switching to IgE isotypes [GO:0048289]; mammary gland epithelial cell proliferation [GO:0033598]; mammary gland morphogenesis [GO:0060443]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of isotype switching to IgE isotypes [GO:0048295]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell population proliferation [GO:0042127]; regulation of mast cell proliferation [GO:0070666]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]; T-helper 1 cell lineage commitment [GO:0002296]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
P42229	reviewed	STA5A_HUMAN	Signal transducer and activator of transcription 5A	STAT5A STAT5	Homo sapiens (Human)	794	FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. {ECO:0000269|PubMed:15534001}.		cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eosinophil differentiation [GO:0030222]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-5-mediated signaling pathway [GO:0038043]; interleukin-9-mediated signaling pathway [GO:0038113]; lactation [GO:0007595]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; reelin-mediated signaling pathway [GO:0038026]; regulation of cell population proliferation [GO:0042127]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; taurine metabolic process [GO:0019530]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eosinophil differentiation [GO:0030222]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-5-mediated signaling pathway [GO:0038043]; interleukin-9-mediated signaling pathway [GO:0038113]; lactation [GO:0007595]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; reelin-mediated signaling pathway [GO:0038026]; regulation of cell population proliferation [GO:0042127]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; taurine metabolic process [GO:0019530]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15534001}. Nucleus {ECO:0000269|PubMed:15534001}. Note=Translocated into the nucleus in response to phosphorylation.
P42261	reviewed	GRIA1_HUMAN	Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1)	GRIA1 GLUH1 GLUR1	Homo sapiens (Human)	906	FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611, ECO:0000269|PubMed:28628100, ECO:0000269|PubMed:35675825}.	MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.	cellular response to amine stimulus [GO:0071418]; cellular response to amino acid stimulus [GO:0071230]; cellular response to ammonium ion [GO:0071242]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to dsRNA [GO:0071359]; cellular response to peptide hormone stimulus [GO:0071375]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; long-term memory [GO:0007616]; long-term synaptic depression [GO:0060292]; modulation of chemical synaptic transmission [GO:0050804]; neuronal action potential [GO:0019228]; positive regulation of gene expression [GO:0010628]; positive regulation of membrane potential [GO:0045838]; positive regulation of synaptic transmission [GO:0050806]; receptor internalization [GO:0031623]; regulation of receptor recycling [GO:0001919]; response to arsenic-containing substance [GO:0046685]; response to cocaine [GO:0042220]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to fungicide [GO:0060992]; response to lithium ion [GO:0010226]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; synapse assembly [GO:0007416]; synaptic transmission, glutamatergic [GO:0035249]	AMPA glutamate receptor complex [GO:0032281]; axonal spine [GO:0044308]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; dendritic spine membrane [GO:0032591]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; perisynaptic space [GO:0099544]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic membrane [GO:0097060]; synaptic vesicle membrane [GO:0030672]	adenylate cyclase binding [GO:0008179]; AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; beta-2 adrenergic receptor binding [GO:0031698]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; glutamate receptor activity [GO:0008066]; glutamate receptor binding [GO:0035254]; identical protein binding [GO:0042802]; immunoglobulin binding [GO:0019865]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; myosin V binding [GO:0031489]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583]; PDZ domain binding [GO:0030165]; protein kinase A binding [GO:0051018]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; small GTPase binding [GO:0031267]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	AMPA glutamate receptor complex [GO:0032281]; axonal spine [GO:0044308]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; dendritic spine membrane [GO:0032591]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; perisynaptic space [GO:0099544]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic membrane [GO:0097060]; synaptic vesicle membrane [GO:0030672]; adenylate cyclase binding [GO:0008179]; AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; beta-2 adrenergic receptor binding [GO:0031698]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; glutamate receptor activity [GO:0008066]; glutamate receptor binding [GO:0035254]; identical protein binding [GO:0042802]; immunoglobulin binding [GO:0019865]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; myosin V binding [GO:0031489]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583]; PDZ domain binding [GO:0030165]; protein kinase A binding [GO:0051018]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; small GTPase binding [GO:0031267]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; cellular response to amine stimulus [GO:0071418]; cellular response to amino acid stimulus [GO:0071230]; cellular response to ammonium ion [GO:0071242]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to dsRNA [GO:0071359]; cellular response to peptide hormone stimulus [GO:0071375]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; long-term memory [GO:0007616]; long-term synaptic depression [GO:0060292]; modulation of chemical synaptic transmission [GO:0050804]; neuronal action potential [GO:0019228]; positive regulation of gene expression [GO:0010628]; positive regulation of membrane potential [GO:0045838]; positive regulation of synaptic transmission [GO:0050806]; receptor internalization [GO:0031623]; regulation of receptor recycling [GO:0001919]; response to arsenic-containing substance [GO:0046685]; response to cocaine [GO:0042220]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to fungicide [GO:0060992]; response to lithium ion [GO:0010226]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; synapse assembly [GO:0007416]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P23818}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23818}. Cell projection, dendrite {ECO:0000250|UniProtKB:P23818}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P23818}. Early endosome membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Recycling endosome membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Presynapse {ECO:0000250|UniProtKB:P23818}. Synapse {ECO:0000250|UniProtKB:P23818}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). Localized to cone photoreceptor pedicles (By similarity). {ECO:0000250|UniProtKB:P19490, ECO:0000250|UniProtKB:P23818}.
P42262	reviewed	GRIA2_HUMAN	Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2)	GRIA2 GLUR2	Homo sapiens (Human)	883	FUNCTION: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system (PubMed:31300657). It plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P19491, ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:31300657}.	MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.	chemical synaptic transmission [GO:0007268]; ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]	AMPA glutamate receptor complex [GO:0032281]; asymmetric synapse [GO:0032279]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; excitatory synapse [GO:0060076]; external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic endocytic zone [GO:0098843]	AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; ionotropic glutamate receptor activity [GO:0004970]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	AMPA glutamate receptor complex [GO:0032281]; asymmetric synapse [GO:0032279]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; excitatory synapse [GO:0060076]; external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic endocytic zone [GO:0098843]; AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; ionotropic glutamate receptor activity [GO:0004970]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; chemical synaptic transmission [GO:0007268]; ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23739980, ECO:0000269|PubMed:31300657}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P23819}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23819}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P23819}.
P42263	reviewed	GRIA3_HUMAN	Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3)	GRIA3 GLUR3 GLURC	Homo sapiens (Human)	894	FUNCTION: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:21172611}.	MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.	glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]	AMPA glutamate receptor complex [GO:0032281]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	AMPA glutamate receptor complex [GO:0032281]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.
P42285	reviewed	MTREX_HUMAN	Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase)	MTREX DOB1 KIAA0052 MTR4 SKIV2L2	Homo sapiens (Human)	1042	FUNCTION: Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension (PubMed:27871484, PubMed:29844170, PubMed:29906447). Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) (PubMed:27871484, PubMed:29844170, PubMed:21855801). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484, PubMed:29844170). PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand (PubMed:29844170). Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (PubMed:29906447). Plays a role in DNA damage response (PubMed:29902117). {ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:29107693, ECO:0000269|PubMed:29844170, ECO:0000269|PubMed:29902117, ECO:0000269|PubMed:29906447}.		DNA damage response [GO:0006974]; maturation of 5.8S rRNA [GO:0000460]; mRNA splicing, via spliceosome [GO:0000398]; RNA catabolic process [GO:0006401]; rRNA processing [GO:0006364]; snRNA catabolic process [GO:0016076]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; DNA damage response [GO:0006974]; maturation of 5.8S rRNA [GO:0000460]; mRNA splicing, via spliceosome [GO:0000398]; RNA catabolic process [GO:0006401]; rRNA processing [GO:0006364]; snRNA catabolic process [GO:0016076]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:30842217}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:16782053}. Nucleus speckle {ECO:0000269|PubMed:30842217}.
P42330	reviewed	AK1C3_HUMAN	Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64)	AKR1C3 DDH1 HSD17B5 KIAA0119 PGFS	Homo sapiens (Human)	323	FUNCTION: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:14672942, PubMed:11165022). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:15047184, PubMed:20036328, PubMed:10622721, PubMed:11165022, PubMed:10998348, PubMed:19010934). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10998348, PubMed:14672942, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:10557352). Also displays retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338). {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15047184, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:20036328, ECO:0000269|PubMed:21851338, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}.		cellular response to calcium ion [GO:0071277]; cellular response to corticosteroid stimulus [GO:0071384]; cellular response to jasmonic acid stimulus [GO:0071395]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to prostaglandin stimulus [GO:0071379]; cellular response to starvation [GO:0009267]; cyclooxygenase pathway [GO:0019371]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; farnesol catabolic process [GO:0016488]; G protein-coupled receptor signaling pathway [GO:0007186]; keratinocyte differentiation [GO:0030216]; macromolecule metabolic process [GO:0043170]; male gonad development [GO:0008584]; negative regulation of retinoic acid biosynthetic process [GO:1900053]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; regulation of testosterone biosynthetic process [GO:2000224]; renal absorption [GO:0070293]; response to nutrient [GO:0007584]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202]; testosterone biosynthetic process [GO:0061370]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; delta4-3-oxosteroid 5beta-reductase activity [GO:0047787]; dihydrotestosterone 17-beta-dehydrogenase activity [GO:0035410]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; geranylgeranyl reductase activity [GO:0045550]; ketoreductase activity [GO:0045703]; ketosteroid monooxygenase activity [GO:0047086]; NAD-retinol dehydrogenase activity [GO:0004745]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; phenanthrene 9,10-monooxygenase activity [GO:0018636]; prostaglandin D2 11-ketoreductase activity [GO:0036131]; prostaglandin H2 endoperoxidase reductase activity [GO:0036130]; prostaglandin-F synthase activity [GO:0047017]; retinal dehydrogenase activity [GO:0001758]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase (NAD+) activity [GO:0047035]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; delta4-3-oxosteroid 5beta-reductase activity [GO:0047787]; dihydrotestosterone 17-beta-dehydrogenase activity [GO:0035410]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; geranylgeranyl reductase activity [GO:0045550]; ketoreductase activity [GO:0045703]; ketosteroid monooxygenase activity [GO:0047086]; NAD-retinol dehydrogenase activity [GO:0004745]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; phenanthrene 9,10-monooxygenase activity [GO:0018636]; prostaglandin D2 11-ketoreductase activity [GO:0036131]; prostaglandin H2 endoperoxidase reductase activity [GO:0036130]; prostaglandin-F synthase activity [GO:0047017]; retinal dehydrogenase activity [GO:0001758]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; cellular response to calcium ion [GO:0071277]; cellular response to corticosteroid stimulus [GO:0071384]; cellular response to jasmonic acid stimulus [GO:0071395]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to prostaglandin stimulus [GO:0071379]; cellular response to starvation [GO:0009267]; cyclooxygenase pathway [GO:0019371]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; farnesol catabolic process [GO:0016488]; G protein-coupled receptor signaling pathway [GO:0007186]; keratinocyte differentiation [GO:0030216]; macromolecule metabolic process [GO:0043170]; male gonad development [GO:0008584]; negative regulation of retinoic acid biosynthetic process [GO:1900053]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; regulation of testosterone biosynthetic process [GO:2000224]; renal absorption [GO:0070293]; response to nutrient [GO:0007584]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202]; testosterone biosynthetic process [GO:0061370]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10622721}.
P42331	reviewed	RHG25_HUMAN	Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25)	ARHGAP25 KIAA0053	Homo sapiens (Human)	645	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.		actin filament organization [GO:0007015]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; signal transduction [GO:0007165]	phagocytic cup [GO:0001891]	GTPase activator activity [GO:0005096]	phagocytic cup [GO:0001891]; GTPase activator activity [GO:0005096]; actin filament organization [GO:0007015]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; signal transduction [GO:0007165]	
P42336	reviewed	PK3CA_HUMAN	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)	PIK3CA	Homo sapiens (Human)	1068	FUNCTION: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396, PubMed:23936502, PubMed:28676499). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396, PubMed:28676499). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed:23936502, PubMed:28676499). Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity). {ECO:0000250|UniProtKB:P42337, ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:21708979, ECO:0000269|PubMed:23936502, ECO:0000269|PubMed:26593112, ECO:0000269|PubMed:28676499}.	MISCELLANEOUS: The avian sarcoma virus 16 genome encodes an oncogene derived from PIK3CA. {ECO:0000305|PubMed:18418043}.	actin cytoskeleton organization [GO:0030036]; adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; anoikis [GO:0043276]; cardiac muscle cell contraction [GO:0086003]; cardiac muscle contraction [GO:0060048]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to insulin stimulus [GO:0032869]; endothelial cell migration [GO:0043542]; energy homeostasis [GO:0097009]; epidermal growth factor receptor signaling pathway [GO:0007173]; genomic imprinting [GO:0071514]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; insulin-like growth factor receptor signaling pathway [GO:0048009]; liver development [GO:0001889]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of anoikis [GO:2000811]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of gene expression [GO:0010629]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron apoptotic process [GO:0043524]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; platelet activation [GO:0030168]; positive regulation of gene expression via CpG island demethylation [GO:0044029]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of TOR signaling [GO:0032008]; regulation of actin filament organization [GO:0110053]; regulation of cellular respiration [GO:0043457]; regulation of multicellular organism growth [GO:0040014]; relaxation of cardiac muscle [GO:0055119]; response to activity [GO:0014823]; response to butyrate [GO:1903544]; response to dexamethasone [GO:0071548]; response to leucine [GO:0043201]; response to muscle inactivity [GO:0014870]; response to muscle stretch [GO:0035994]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor signaling pathway [GO:0038084]; vasculature development [GO:0001944]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; insulin receptor substrate binding [GO:0043560]; kinase activity [GO:0016301]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; insulin receptor substrate binding [GO:0043560]; kinase activity [GO:0016301]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; actin cytoskeleton organization [GO:0030036]; adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; anoikis [GO:0043276]; cardiac muscle cell contraction [GO:0086003]; cardiac muscle contraction [GO:0060048]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to insulin stimulus [GO:0032869]; endothelial cell migration [GO:0043542]; energy homeostasis [GO:0097009]; epidermal growth factor receptor signaling pathway [GO:0007173]; genomic imprinting [GO:0071514]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; insulin-like growth factor receptor signaling pathway [GO:0048009]; liver development [GO:0001889]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of anoikis [GO:2000811]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of gene expression [GO:0010629]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron apoptotic process [GO:0043524]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; platelet activation [GO:0030168]; positive regulation of gene expression via CpG island demethylation [GO:0044029]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of TOR signaling [GO:0032008]; regulation of actin filament organization [GO:0110053]; regulation of cellular respiration [GO:0043457]; regulation of multicellular organism growth [GO:0040014]; relaxation of cardiac muscle [GO:0055119]; response to activity [GO:0014823]; response to butyrate [GO:1903544]; response to dexamethasone [GO:0071548]; response to leucine [GO:0043201]; response to muscle inactivity [GO:0014870]; response to muscle stretch [GO:0035994]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor signaling pathway [GO:0038084]; vasculature development [GO:0001944]	
P42338	reviewed	PK3CB_HUMAN	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1)	PIK3CB PIK3C1	Homo sapiens (Human)	1070	FUNCTION: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Has also a protein kinase activity showing autophosphorylation (PubMed:12502714). {ECO:0000269|PubMed:12502714, ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:18594509, ECO:0000269|PubMed:18755892, ECO:0000269|PubMed:21030680, ECO:0000269|PubMed:21383062}.		angiogenesis involved in wound healing [GO:0060055]; autophagy [GO:0006914]; cell migration [GO:0016477]; chemotaxis [GO:0006935]; embryonic cleavage [GO:0040016]; endocytosis [GO:0006897]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of autophagy [GO:0010508]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of Rac protein signal transduction [GO:0035022]; regulation of cell-matrix adhesion [GO:0001952]; regulation of clathrin-dependent endocytosis [GO:2000369]; response to ischemia [GO:0002931]; signal transduction [GO:0007165]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; insulin receptor substrate binding [GO:0043560]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; insulin receptor substrate binding [GO:0043560]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; angiogenesis involved in wound healing [GO:0060055]; autophagy [GO:0006914]; cell migration [GO:0016477]; chemotaxis [GO:0006935]; embryonic cleavage [GO:0040016]; endocytosis [GO:0006897]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of autophagy [GO:0010508]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of Rac protein signal transduction [GO:0035022]; regulation of cell-matrix adhesion [GO:0001952]; regulation of clathrin-dependent endocytosis [GO:2000369]; response to ischemia [GO:0002931]; signal transduction [GO:0007165]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21383062}. Nucleus {ECO:0000269|PubMed:21383062}. Note=Interaction with PIK3R2 is required for nuclear localization and export.
P42345	reviewed	MTOR_HUMAN	Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)	MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1	Homo sapiens (Human)	2549	FUNCTION: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:29236692). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18925875, PubMed:18372248, PubMed:18497260, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29236692). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18925875, PubMed:18497260, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:31112131, PubMed:34519269, PubMed:29236692). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12150925, PubMed:12087098, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429704, PubMed:23429703). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (By similarity). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton (PubMed:15268862, PubMed:15467718). mTORC2 plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1 (PubMed:15718470). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). Phosphorylates SQSTM1, promoting interaction between SQSTM1 and KEAP1 and subsequent inactivation of the BCR(KEAP1) complex (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823}.		'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; anoikis [GO:0043276]; behavioral response to pain [GO:0048266]; calcineurin-NFAT signaling cascade [GO:0033173]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to nutrient [GO:0031670]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cellular response to starvation [GO:0009267]; cytoskeleton organization [GO:0007010]; DNA damage response [GO:0006974]; energy reserve metabolic process [GO:0006112]; germ cell development [GO:0007281]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; inflammatory response [GO:0006954]; lysosome organization [GO:0007040]; macroautophagy [GO:0016236]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cell size [GO:0045792]; negative regulation of lysosome organization [GO:1905672]; negative regulation of macroautophagy [GO:0016242]; negative regulation of protein localization to nucleus [GO:1900181]; neuronal action potential [GO:0019228]; nucleus localization [GO:0051647]; oligodendrocyte differentiation [GO:0048709]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of cytoplasmic translational initiation [GO:1904690]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; post-embryonic development [GO:0009791]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of autophagosome assembly [GO:2000785]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; regulation of cellular response to heat [GO:1900034]; regulation of circadian rhythm [GO:0042752]; regulation of locomotor rhythm [GO:1904059]; regulation of macroautophagy [GO:0016241]; regulation of membrane permeability [GO:0090559]; regulation of myelination [GO:0031641]; regulation of osteoclast differentiation [GO:0045670]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to amino acid [GO:0043200]; response to heat [GO:0009408]; response to nutrient [GO:0007584]; response to nutrient levels [GO:0031667]; rhythmic process [GO:0048511]; ruffle organization [GO:0031529]; T cell costimulation [GO:0031295]; T-helper 1 cell lineage commitment [GO:0002296]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; voluntary musculoskeletal movement [GO:0050882]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; PML body [GO:0016605]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosome binding [GO:0043022]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TFIIIC-class transcription factor complex binding [GO:0001156]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; PML body [GO:0016605]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosome binding [GO:0043022]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TFIIIC-class transcription factor complex binding [GO:0001156]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; anoikis [GO:0043276]; behavioral response to pain [GO:0048266]; calcineurin-NFAT signaling cascade [GO:0033173]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to nutrient [GO:0031670]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cellular response to starvation [GO:0009267]; cytoskeleton organization [GO:0007010]; DNA damage response [GO:0006974]; energy reserve metabolic process [GO:0006112]; germ cell development [GO:0007281]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; inflammatory response [GO:0006954]; lysosome organization [GO:0007040]; macroautophagy [GO:0016236]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cell size [GO:0045792]; negative regulation of lysosome organization [GO:1905672]; negative regulation of macroautophagy [GO:0016242]; negative regulation of protein localization to nucleus [GO:1900181]; neuronal action potential [GO:0019228]; nucleus localization [GO:0051647]; oligodendrocyte differentiation [GO:0048709]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of cytoplasmic translational initiation [GO:1904690]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; post-embryonic development [GO:0009791]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of autophagosome assembly [GO:2000785]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; regulation of cellular response to heat [GO:1900034]; regulation of circadian rhythm [GO:0042752]; regulation of locomotor rhythm [GO:1904059]; regulation of macroautophagy [GO:0016241]; regulation of membrane permeability [GO:0090559]; regulation of myelination [GO:0031641]; regulation of osteoclast differentiation [GO:0045670]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to amino acid [GO:0043200]; response to heat [GO:0009408]; response to nutrient [GO:0007584]; response to nutrient levels [GO:0031667]; rhythmic process [GO:0048511]; ruffle organization [GO:0031529]; T cell costimulation [GO:0031295]; T-helper 1 cell lineage commitment [GO:0002296]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; voluntary musculoskeletal movement [GO:0050882]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:29750193, ECO:0000269|PubMed:30956113, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601764}; Peripheral membrane protein {ECO:0000269|PubMed:30956113, ECO:0000269|PubMed:31112131}; Cytoplasmic side {ECO:0000269|PubMed:30956113, ECO:0000269|PubMed:31112131}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14578359}; Peripheral membrane protein {ECO:0000269|PubMed:14578359}; Cytoplasmic side {ECO:0000269|PubMed:14578359}. Golgi apparatus membrane {ECO:0000269|PubMed:14578359}; Peripheral membrane protein {ECO:0000269|PubMed:14578359}; Cytoplasmic side {ECO:0000269|PubMed:14578359}. Mitochondrion outer membrane {ECO:0000269|PubMed:11930000, ECO:0000269|PubMed:14578359}; Peripheral membrane protein {ECO:0000269|PubMed:11930000, ECO:0000269|PubMed:14578359}; Cytoplasmic side {ECO:0000269|PubMed:11930000, ECO:0000269|PubMed:14578359}. Cytoplasm {ECO:0000269|PubMed:11930000, ECO:0000269|PubMed:18497260}. Nucleus {ECO:0000250|UniProtKB:Q9JLN9}. Nucleus, PML body {ECO:0000250|UniProtKB:Q9JLN9}. Microsome membrane {ECO:0000269|PubMed:9434772}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:27623384}. Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). Lysosome targeting also depends on interaction with MEAK7. Translocates to the lysosome membrane in the presence of TM4SF5 (PubMed:30956113). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:29750193, ECO:0000269|PubMed:30956113}.
P42356	reviewed	PI4KA_HUMAN	Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha)	PI4KA PIK4 PIK4CA	Homo sapiens (Human)	2102	FUNCTION: Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}.		modulation by host of viral process [GO:0044788]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; reorganization of cellular membranes to establish viral sites of replication [GO:0140754]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi-associated vesicle membrane [GO:0030660]; membrane [GO:0016020]; plasma membrane [GO:0005886]	1-phosphatidylinositol 4-kinase activity [GO:0004430]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; kinase activity [GO:0016301]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi-associated vesicle membrane [GO:0030660]; membrane [GO:0016020]; plasma membrane [GO:0005886]; 1-phosphatidylinositol 4-kinase activity [GO:0004430]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; kinase activity [GO:0016301]; modulation by host of viral process [GO:0044788]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; reorganization of cellular membranes to establish viral sites of replication [GO:0140754]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. Cell membrane {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. Note=Localization to the plasma membrane is mediated by the PI4K complex and association with EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2) (PubMed:23229899). Localization to the plasma membrane is regulated by TMEM150A (PubMed:25608530). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25608530}.
P42566	reviewed	EPS15_HUMAN	Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)	EPS15 AF1P	Homo sapiens (Human)	896	FUNCTION: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.		clathrin coat assembly [GO:0048268]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; Golgi to endosome transport [GO:0006895]; positive regulation of receptor recycling [GO:0001921]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; protein transport [GO:0015031]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of cell population proliferation [GO:0042127]; vesicle organization [GO:0016050]; viral entry into host cell [GO:0046718]	aggresome [GO:0016235]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; clathrin coat of coated pit [GO:0030132]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; polyubiquitin modification-dependent protein binding [GO:0031593]; SH3 domain binding [GO:0017124]	aggresome [GO:0016235]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; clathrin coat of coated pit [GO:0030132]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; polyubiquitin modification-dependent protein binding [GO:0031593]; SH3 domain binding [GO:0017124]; clathrin coat assembly [GO:0048268]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; Golgi to endosome transport [GO:0006895]; positive regulation of receptor recycling [GO:0001921]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; protein transport [GO:0015031]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of cell population proliferation [GO:0042127]; vesicle organization [GO:0016050]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. {ECO:0000269|PubMed:16159959}.; SUBCELLULAR LOCATION: [Isoform 2]: Early endosome membrane {ECO:0000269|PubMed:18362181}; Peripheral membrane protein {ECO:0000269|PubMed:18362181}; Cytoplasmic side {ECO:0000269|PubMed:18362181}. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes.
P42568	reviewed	AF9_HUMAN	Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)	MLLT3 AF9 YEATS3	Homo sapiens (Human)	568	FUNCTION: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than confering, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:27545619, ECO:0000269|PubMed:30374167, ECO:0000269|PubMed:30385749, ECO:0000269|PubMed:31776511}.		anterior/posterior pattern specification [GO:0009952]; gene expression [GO:0010467]; hematopoietic stem cell differentiation [GO:0060218]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of chromatin organization [GO:1902275]; regulation of stem cell division [GO:2000035]; segment specification [GO:0007379]	chromosome [GO:0005694]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; modification-dependent protein binding [GO:0140030]; molecular adaptor activity [GO:0060090]	chromosome [GO:0005694]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; modification-dependent protein binding [GO:0140030]; molecular adaptor activity [GO:0060090]; anterior/posterior pattern specification [GO:0009952]; gene expression [GO:0010467]; hematopoietic stem cell differentiation [GO:0060218]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of chromatin organization [GO:1902275]; regulation of stem cell division [GO:2000035]; segment specification [GO:0007379]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00376, ECO:0000269|PubMed:27105114}. Chromosome {ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114}. Note=Colocalizes with acylated histone H3 (PubMed:25417107, PubMed:27105114). Colocalizes with histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). {ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114}.
P42574	reviewed	CASP3_HUMAN	Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]	CASP3 CPP32	Homo sapiens (Human)	277	FUNCTION: Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:7596430, PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:7596430, PubMed:18723680, PubMed:20566630, PubMed:23650375). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond (PubMed:7774019, PubMed:7596430, PubMed:10497198, PubMed:16374543). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity). Cleaves and activates caspase-6, -7 and -9 (PubMed:7596430). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed:35446120, PubMed:35338844). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486). {ECO:0000250|UniProtKB:Q60431, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23845944, ECO:0000269|PubMed:30878284, ECO:0000269|PubMed:33725486, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:7596430, ECO:0000269|PubMed:7774019, ECO:0000269|PubMed:8696339}.		anterior neural tube closure [GO:0061713]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; axonal fasciculation [GO:0007413]; B cell homeostasis [GO:0001782]; cell fate commitment [GO:0045165]; cellular response to staurosporine [GO:0072734]; DNA damage response [GO:0006974]; epithelial cell apoptotic process [GO:1904019]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; glial cell apoptotic process [GO:0034349]; heart development [GO:0007507]; hippocampus development [GO:0021766]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to osmotic stress [GO:0008627]; keratinocyte differentiation [GO:0030216]; learning or memory [GO:0007611]; leukocyte apoptotic process [GO:0071887]; luteolysis [GO:0001554]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell cycle [GO:0045786]; negative regulation of cytokine production [GO:0001818]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet formation [GO:0030220]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of pyroptosis [GO:0140639]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; regulation of macroautophagy [GO:0016241]; regulation of protein stability [GO:0031647]; response to amino acid [GO:0043200]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; response to wounding [GO:0009611]; response to X-ray [GO:0010165]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; striated muscle cell differentiation [GO:0051146]; T cell homeostasis [GO:0043029]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	aspartic-type endopeptidase activity [GO:0004190]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; death receptor binding [GO:0005123]; peptidase activity [GO:0008233]; phospholipase A2 activator activity [GO:0016005]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; aspartic-type endopeptidase activity [GO:0004190]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; death receptor binding [GO:0005123]; peptidase activity [GO:0008233]; phospholipase A2 activator activity [GO:0016005]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; anterior neural tube closure [GO:0061713]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; axonal fasciculation [GO:0007413]; B cell homeostasis [GO:0001782]; cell fate commitment [GO:0045165]; cellular response to staurosporine [GO:0072734]; DNA damage response [GO:0006974]; epithelial cell apoptotic process [GO:1904019]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; glial cell apoptotic process [GO:0034349]; heart development [GO:0007507]; hippocampus development [GO:0021766]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to osmotic stress [GO:0008627]; keratinocyte differentiation [GO:0030216]; learning or memory [GO:0007611]; leukocyte apoptotic process [GO:0071887]; luteolysis [GO:0001554]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell cycle [GO:0045786]; negative regulation of cytokine production [GO:0001818]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet formation [GO:0030220]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of pyroptosis [GO:0140639]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; regulation of macroautophagy [GO:0016241]; regulation of protein stability [GO:0031647]; response to amino acid [GO:0043200]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; response to wounding [GO:0009611]; response to X-ray [GO:0010165]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; striated muscle cell differentiation [GO:0051146]; T cell homeostasis [GO:0043029]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15003516}.
P42575	reviewed	CASP2_HUMAN	Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]	CASP2 ICH1 NEDD2	Homo sapiens (Human)	452	FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). {ECO:0000269|PubMed:15073321}.	MISCELLANEOUS: [Isoform 1]: Acts as a positive regulator of apoptosis.; MISCELLANEOUS: [Isoform 2]: Acts as a negative regulator of apoptosis. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. {ECO:0000305}.	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ectopic germ cell programmed cell death [GO:0035234]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; luteolysis [GO:0001554]; negative regulation of apoptotic process [GO:0043066]; neural retina development [GO:0003407]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; nucleolus [GO:0005730]; nucleus [GO:0005634]	cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; nucleolus [GO:0005730]; nucleus [GO:0005634]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ectopic germ cell programmed cell death [GO:0035234]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; luteolysis [GO:0001554]; negative regulation of apoptotic process [GO:0043066]; neural retina development [GO:0003407]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]	
P42658	reviewed	DPP6_HUMAN	Dipeptidyl aminopeptidase-like protein 6 (DPPX) (Dipeptidyl aminopeptidase-related protein) (Dipeptidyl peptidase 6) (Dipeptidyl peptidase IV-like protein) (Dipeptidyl peptidase VI) (DPP VI)	DPP6	Homo sapiens (Human)	865	FUNCTION: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821). {ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:18364354, ECO:0000269|PubMed:8103397, ECO:0000305|PubMed:15476821}.	MISCELLANEOUS: Genetic variation in DPP6 may influence susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a severely disabling and lethal disorder caused by progressive degeneration of motor neurons in the brain, spinal cord and brainstem.	protein localization to plasma membrane [GO:0072659]; proteolysis [GO:0006508]; regulation of potassium ion transmembrane transport [GO:1901379]	membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	potassium channel regulator activity [GO:0015459]; serine-type peptidase activity [GO:0008236]	membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; potassium channel regulator activity [GO:0015459]; serine-type peptidase activity [GO:0008236]; protein localization to plasma membrane [GO:0072659]; proteolysis [GO:0006508]; regulation of potassium ion transmembrane transport [GO:1901379]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18364354, ECO:0000269|PubMed:19441798}; Single-pass type II membrane protein {ECO:0000305}.
P42677	reviewed	RS27_HUMAN	Small ribosomal subunit protein eS27 (40S ribosomal protein S27) (Metallopan-stimulin 1) (MPS-1)	RPS27 MPS1	Homo sapiens (Human)	84	FUNCTION: Component of the small ribosomal subunit (PubMed:8706699, PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}.		cytoplasmic translation [GO:0002181]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]	DNA binding [GO:0003677]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270]; cytoplasmic translation [GO:0002181]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
P42679	reviewed	MATK_HUMAN	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK)	MATK CTK HYL	Homo sapiens (Human)	507	FUNCTION: Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. {ECO:0000269|PubMed:9171348}.		positive regulation of cell population proliferation [GO:0008284]; protein phosphorylation [GO:0006468]	cytosol [GO:0005829]; membrane [GO:0016020]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]	cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; positive regulation of cell population proliferation [GO:0008284]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9171348}. Membrane {ECO:0000269|PubMed:9171348}. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
P42680	reviewed	TEC_HUMAN	Tyrosine-protein kinase Tec (EC 2.7.10.2)	TEC PSCTK4	Homo sapiens (Human)	631	FUNCTION: Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. {ECO:0000269|PubMed:10518561, ECO:0000269|PubMed:19883687, ECO:0000269|PubMed:20230531, ECO:0000269|PubMed:9753425}.		adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of platelet activation [GO:0010543]; T cell receptor signaling pathway [GO:0050852]; tissue regeneration [GO:0042246]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phospholipid binding [GO:0005543]; protein self-association [GO:0043621]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phospholipid binding [GO:0005543]; protein self-association [GO:0043621]; adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of platelet activation [GO:0010543]; T cell receptor signaling pathway [GO:0050852]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). {ECO:0000250}.
P42681	reviewed	TXK_HUMAN	Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase)	TXK PTK4 RLK	Homo sapiens (Human)	527	FUNCTION: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976). Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976). Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. {ECO:0000269|PubMed:10523612, ECO:0000269|PubMed:11564877, ECO:0000269|PubMed:11859127, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:9813138}.		activation of phospholipase C activity [GO:0007202]; adaptive immune response [GO:0002250]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of cytokine production [GO:0001819]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of gene expression [GO:0010468]; regulation of platelet activation [GO:0010543]; T cell receptor signaling pathway [GO:0050852]; tissue regeneration [GO:0042246]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; activation of phospholipase C activity [GO:0007202]; adaptive immune response [GO:0002250]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of cytokine production [GO:0001819]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of gene expression [GO:0010468]; regulation of platelet activation [GO:0010543]; T cell receptor signaling pathway [GO:0050852]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17177976}. Nucleus {ECO:0000269|PubMed:17177976}. Cell membrane {ECO:0000269|PubMed:17177976}; Peripheral membrane protein {ECO:0000269|PubMed:17177976}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.
P42684	reviewed	ABL2_HUMAN	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)	ABL2 ABLL ARG	Homo sapiens (Human)	1182	FUNCTION: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}.		cell adhesion [GO:0007155]; cellular response to retinoic acid [GO:0071300]; exploration behavior [GO:0035640]; negative regulation of Rho protein signal transduction [GO:0035024]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of neuron projection development [GO:0010976]; positive regulation of oxidoreductase activity [GO:0051353]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of T cell migration [GO:2000406]; protein modification process [GO:0036211]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of cell adhesion [GO:0030155]; regulation of cell motility [GO:2000145]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]	actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; cell adhesion [GO:0007155]; cellular response to retinoic acid [GO:0071300]; exploration behavior [GO:0035640]; negative regulation of Rho protein signal transduction [GO:0035024]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of neuron projection development [GO:0010976]; positive regulation of oxidoreductase activity [GO:0051353]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of T cell migration [GO:2000406]; protein modification process [GO:0036211]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of cell adhesion [GO:0030155]; regulation of cell motility [GO:2000145]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q4JIM5}.
P42685	reviewed	FRK_HUMAN	Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)	FRK PTK5 RAK	Homo sapiens (Human)	505	FUNCTION: Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}.		cell differentiation [GO:0030154]; innate immune response [GO:0045087]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphorylation [GO:0016310]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; cell differentiation [GO:0030154]; innate immune response [GO:0045087]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphorylation [GO:0016310]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7696183}. Nucleus {ECO:0000269|PubMed:7696183}. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.
P42694	reviewed	HELZ_HUMAN	Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein)	HELZ DRHC KIAA0054	Homo sapiens (Human)	1942	FUNCTION: May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.		regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P granule [GO:0043186]	ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P granule [GO:0043186]; ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P42695	reviewed	CNDD3_HUMAN	Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3)	NCAPD3 CAPD3 KIAA0056	Homo sapiens (Human)	1498	FUNCTION: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}.		cell division [GO:0051301]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	condensed chromosome, centromeric region [GO:0000779]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; pericentric heterochromatin [GO:0005721]	histone binding [GO:0042393]; methylated histone binding [GO:0035064]	condensed chromosome, centromeric region [GO:0000779]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; pericentric heterochromatin [GO:0005721]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; cell division [GO:0051301]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14532007}.
P42701	reviewed	I12R1_HUMAN	Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12RB1) (IL-12 receptor beta component) (CD antigen CD212)	IL12RB1 IL12R IL12RB	Homo sapiens (Human)	662	FUNCTION: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. {ECO:0000269|PubMed:12023369}.		cellular response to type II interferon [GO:0071346]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165]	external side of plasma membrane [GO:0009897]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]	external side of plasma membrane [GO:0009897]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; cellular response to type II interferon [GO:0071346]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P42702	reviewed	LIFR_HUMAN	Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118)	LIFR	Homo sapiens (Human)	1097	FUNCTION: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.		cell surface receptor signaling pathway [GO:0007166]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; leukemia inhibitory factor signaling pathway [GO:0048861]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of cell population proliferation [GO:0008284]; response to cytokine [GO:0034097]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]; leukemia inhibitory factor receptor activity [GO:0004923]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]; leukemia inhibitory factor receptor activity [GO:0004923]; cell surface receptor signaling pathway [GO:0007166]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; leukemia inhibitory factor signaling pathway [GO:0048861]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of cell population proliferation [GO:0008284]; response to cytokine [GO:0034097]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
P42704	reviewed	LPPRC_HUMAN	Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130)	LRPPRC LRP130	Homo sapiens (Human)	1394	FUNCTION: May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:28325843}.		mitochondrial RNA catabolic process [GO:0000957]; mitochondrion transport along microtubule [GO:0047497]; mRNA transport [GO:0051028]; negative regulation of mitochondrial RNA catabolic process [GO:0000961]; regulation of mitochondrial translation [GO:0070129]	condensed nuclear chromosome [GO:0000794]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]	beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625]	condensed nuclear chromosome [GO:0000794]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrion transport along microtubule [GO:0047497]; mRNA transport [GO:0051028]; negative regulation of mitochondrial RNA catabolic process [GO:0000961]; regulation of mitochondrial translation [GO:0070129]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19262567}. Nucleus {ECO:0000269|PubMed:19262567}. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus outer membrane. Note=Seems to be predominantly mitochondrial.
P42765	reviewed	THIM_HUMAN	3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1)	ACAA2	Homo sapiens (Human)	397	FUNCTION: In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:25478839). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed:18371312). {ECO:0000269|PubMed:18371312, ECO:0000269|PubMed:25478839, ECO:0000305|PubMed:25478839}.		cellular response to hypoxia [GO:0071456]; cholesterol biosynthetic process [GO:0006695]; fatty acid beta-oxidation [GO:0006635]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA hydrolase activity [GO:0003986]; acyl-CoA hydrolase activity [GO:0047617]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; RNA binding [GO:0003723]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA hydrolase activity [GO:0003986]; acyl-CoA hydrolase activity [GO:0047617]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; RNA binding [GO:0003723]; cellular response to hypoxia [GO:0071456]; cholesterol biosynthetic process [GO:0006695]; fatty acid beta-oxidation [GO:0006635]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18371312}.
P42766	reviewed	RL35_HUMAN	Large ribosomal subunit protein uL29 (60S ribosomal protein L35)	RPL35	Homo sapiens (Human)	123	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; nucleolus [GO:0005730]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; nucleolus [GO:0005730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P42768	reviewed	WASP_HUMAN	Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)	WAS IMD2	Homo sapiens (Human)	502	FUNCTION: Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:12235133, ECO:0000269|PubMed:12769847, ECO:0000269|PubMed:16275905, ECO:0000269|PubMed:18650809, ECO:0000269|PubMed:20574068, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:8625410, ECO:0000269|PubMed:9405671}.		actin filament polymerization [GO:0030041]; actin filament-based movement [GO:0030048]; actin polymerization or depolymerization [GO:0008154]; blood coagulation [GO:0007596]; Cdc42 protein signal transduction [GO:0032488]; cellular response to type II interferon [GO:0071346]; defense response [GO:0006952]; endosomal transport [GO:0016197]; epidermis development [GO:0008544]; immune response [GO:0006955]; negative regulation of cell motility [GO:2000146]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of lamellipodium assembly [GO:0010591]; regulation of stress fiber assembly [GO:0051492]; regulation of T cell antigen processing and presentation [GO:0002625]; T cell activation [GO:0042110]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; vesicle membrane [GO:0012506]	actin binding [GO:0003779]; GTPase regulator activity [GO:0030695]; identical protein binding [GO:0042802]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; vesicle membrane [GO:0012506]; actin binding [GO:0003779]; GTPase regulator activity [GO:0030695]; identical protein binding [GO:0042802]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]; actin filament polymerization [GO:0030041]; actin filament-based movement [GO:0030048]; actin polymerization or depolymerization [GO:0008154]; blood coagulation [GO:0007596]; Cdc42 protein signal transduction [GO:0032488]; cellular response to type II interferon [GO:0071346]; defense response [GO:0006952]; endosomal transport [GO:0016197]; epidermis development [GO:0008544]; immune response [GO:0006955]; negative regulation of cell motility [GO:2000146]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of lamellipodium assembly [GO:0010591]; regulation of stress fiber assembly [GO:0051492]; regulation of T cell antigen processing and presentation [GO:0002625]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8625410}. Nucleus {ECO:0000269|PubMed:20574068, ECO:0000269|PubMed:29925947}.
P42771	reviewed	CDN2A_HUMAN	Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)	CDKN2A CDKN2 MTS1	Homo sapiens (Human)	156	FUNCTION: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. {ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:7972006}.	MISCELLANEOUS: [Isoform 5]: Barely detectable in non-tumor cells. {ECO:0000305}.	cell cycle [GO:0007049]; cellular senescence [GO:0090398]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphorylation [GO:0042326]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; replicative senescence [GO:0090399]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; senescence-associated heterochromatin focus [GO:0035985]	cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; NF-kappaB binding [GO:0051059]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; senescence-associated heterochromatin focus [GO:0035985]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; NF-kappaB binding [GO:0051059]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; cell cycle [GO:0007049]; cellular senescence [GO:0090398]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphorylation [GO:0042326]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; replicative senescence [GO:0090399]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17658461}. Nucleus {ECO:0000269|PubMed:17658461}.
P42772	reviewed	CDN2B_HUMAN	Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)	CDKN2B MTS2	Homo sapiens (Human)	138	FUNCTION: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.		cell cycle [GO:0007049]; cellular response to extracellular stimulus [GO:0031668]; cellular response to nutrient [GO:0031670]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular senescence [GO:0090398]; liver development [GO:0001889]; megakaryocyte differentiation [GO:0030219]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of phosphorylation [GO:0042326]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; response to cytokine [GO:0034097]; response to organic cyclic compound [GO:0014070]; spleen development [GO:0048536]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein kinase binding [GO:0019901]; cell cycle [GO:0007049]; cellular response to extracellular stimulus [GO:0031668]; cellular response to nutrient [GO:0031670]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular senescence [GO:0090398]; liver development [GO:0001889]; megakaryocyte differentiation [GO:0030219]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of phosphorylation [GO:0042326]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; response to cytokine [GO:0034097]; response to organic cyclic compound [GO:0014070]; spleen development [GO:0048536]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9230210}. Note=Also found in the nucleus.
P42773	reviewed	CDN2C_HUMAN	Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)	CDKN2C CDKN6	Homo sapiens (Human)	168	FUNCTION: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.		cell cycle [GO:0007049]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phosphorylation [GO:0042326]; negative regulation of stem cell proliferation [GO:2000647]; oligodendrocyte differentiation [GO:0048709]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; stem cell proliferation [GO:0072089]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein kinase binding [GO:0019901]; cell cycle [GO:0007049]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phosphorylation [GO:0042326]; negative regulation of stem cell proliferation [GO:2000647]; oligodendrocyte differentiation [GO:0048709]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; stem cell proliferation [GO:0072089]	
P42785	reviewed	PCP_HUMAN	Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Angiotensinase C) (Lysosomal carboxypeptidase C) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP)	PRCP PCP	Homo sapiens (Human)	496	FUNCTION: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.		angiogenesis involved in wound healing [GO:0060055]; energy homeostasis [GO:0097009]; glucose homeostasis [GO:0042593]; negative regulation of systemic arterial blood pressure [GO:0003085]; plasma kallikrein-kinin cascade [GO:0002353]; proteolysis [GO:0006508]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of thyroid hormone mediated signaling pathway [GO:0002155]	azurophil granule membrane [GO:0035577]; basal part of cell [GO:0045178]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	dipeptidyl-peptidase activity [GO:0008239]; serine-type carboxypeptidase activity [GO:0004185]	azurophil granule membrane [GO:0035577]; basal part of cell [GO:0045178]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; dipeptidyl-peptidase activity [GO:0008239]; serine-type carboxypeptidase activity [GO:0004185]; angiogenesis involved in wound healing [GO:0060055]; energy homeostasis [GO:0097009]; glucose homeostasis [GO:0042593]; negative regulation of systemic arterial blood pressure [GO:0003085]; plasma kallikrein-kinin cascade [GO:0002353]; proteolysis [GO:0006508]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of thyroid hormone mediated signaling pathway [GO:0002155]	SUBCELLULAR LOCATION: Lysosome.
P42830	reviewed	CXCL5_HUMAN	C-X-C motif chemokine 5 (ENA-78(1-78)) (Epithelial-derived neutrophil-activating protein 78) (Neutrophil-activating peptide ENA-78) (Small-inducible cytokine B5) [Cleaved into: ENA-78(8-78); ENA-78(9-78)]	CXCL5 ENA78 SCYB5	Homo sapiens (Human)	114	FUNCTION: Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes. {ECO:0000269|PubMed:10095777}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell population proliferation [GO:0008284]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; identical protein binding [GO:0042802]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; identical protein binding [GO:0042802]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell population proliferation [GO:0008284]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P42857	reviewed	NSG1_HUMAN	Neuronal vesicle trafficking-associated protein 1 (Neuron-enriched endosomal protein of 21 kDa) (Neuron-specific protein family member 1)	NSG1 D4S234 NEEP21	Homo sapiens (Human)	185	FUNCTION: Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061). {ECO:0000250|UniProtKB:P02683, ECO:0000250|UniProtKB:Q62092, ECO:0000269|PubMed:20599942, ECO:0000269|PubMed:20878061}.		amyloid precursor protein metabolic process [GO:0042982]; apoptotic process [GO:0006915]; clathrin coat assembly [GO:0048268]; dopamine receptor signaling pathway [GO:0007212]; endosomal transport [GO:0016197]; neurotransmitter receptor cycle [GO:0099627]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of receptor recycling [GO:0001921]; postsynaptic neurotransmitter receptor cycle [GO:0099630]; receptor recycling [GO:0001881]; regulation of long-term synaptic potentiation [GO:1900271]; spontaneous synaptic transmission [GO:0098814]; vesicle-mediated transport in synapse [GO:0099003]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; Golgi cisterna membrane [GO:0032580]; late endosome [GO:0005770]; lateral plasma membrane [GO:0016328]; lysosomal lumen [GO:0043202]; multivesicular body membrane [GO:0032585]; nucleus [GO:0005634]; postsynaptic endosome [GO:0098845]; postsynaptic membrane [GO:0045211]; recycling endosome membrane [GO:0055038]; somatodendritic compartment [GO:0036477]; trans-Golgi network membrane [GO:0032588]	clathrin light chain binding [GO:0032051]; ionotropic glutamate receptor binding [GO:0035255]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; Golgi cisterna membrane [GO:0032580]; late endosome [GO:0005770]; lateral plasma membrane [GO:0016328]; lysosomal lumen [GO:0043202]; multivesicular body membrane [GO:0032585]; nucleus [GO:0005634]; postsynaptic endosome [GO:0098845]; postsynaptic membrane [GO:0045211]; recycling endosome membrane [GO:0055038]; somatodendritic compartment [GO:0036477]; trans-Golgi network membrane [GO:0032588]; clathrin light chain binding [GO:0032051]; ionotropic glutamate receptor binding [GO:0035255]; amyloid precursor protein metabolic process [GO:0042982]; apoptotic process [GO:0006915]; clathrin coat assembly [GO:0048268]; dopamine receptor signaling pathway [GO:0007212]; endosomal transport [GO:0016197]; neurotransmitter receptor cycle [GO:0099627]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of receptor recycling [GO:0001921]; postsynaptic neurotransmitter receptor cycle [GO:0099630]; receptor recycling [GO:0001881]; regulation of long-term synaptic potentiation [GO:1900271]; spontaneous synaptic transmission [GO:0098814]; vesicle-mediated transport in synapse [GO:0099003]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P02683}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P02683}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P02683}. Endosome membrane {ECO:0000250|UniProtKB:P02683}. Cell projection, dendrite {ECO:0000250|UniProtKB:P02683}. Early endosome membrane {ECO:0000250|UniProtKB:P02683}. Late endosome membrane {ECO:0000250|UniProtKB:P02683}. Lysosome lumen {ECO:0000250|UniProtKB:P02683}. Recycling endosome membrane {ECO:0000250|UniProtKB:P02683}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P02683}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P02683}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:P02683}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20599942}. Note=Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (By similarity). Endoplasmic reticulum targeting is essential for apoptosis (PubMed:20599942). Found in both stationary and motile endosomes. A previous study supports a type I membrane protein topology (By similarity). {ECO:0000250|UniProtKB:P02683, ECO:0000250|UniProtKB:Q62092, ECO:0000269|PubMed:20599942}.
P42858	reviewed	HD_HUMAN	Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]	HTT HD IT15	Homo sapiens (Human)	3142	FUNCTION: [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}.		apoptotic process [GO:0006915]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; microtubule-based transport [GO:0099111]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of aggrephagy [GO:1905337]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of cilium assembly [GO:0045724]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of lipophagy [GO:1904504]; protein destabilization [GO:0031648]; regulation of CAMKK-AMPK signaling cascade [GO:1905289]; regulation of cAMP-dependent protein kinase activity [GO:2000479]; regulation of phosphoprotein phosphatase activity [GO:0043666]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle transport along microtubule [GO:0047496]; vocal learning [GO:0042297]	autophagosome [GO:0005776]; axon [GO:0030424]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; inclusion body [GO:0016234]; late endosome [GO:0005770]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523]; protein-containing complex [GO:0032991]	beta-tubulin binding [GO:0048487]; dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; p53 binding [GO:0002039]; profilin binding [GO:0005522]; transmembrane transporter binding [GO:0044325]	autophagosome [GO:0005776]; axon [GO:0030424]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; inclusion body [GO:0016234]; late endosome [GO:0005770]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523]; protein-containing complex [GO:0032991]; beta-tubulin binding [GO:0048487]; dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; p53 binding [GO:0002039]; profilin binding [GO:0005522]; transmembrane transporter binding [GO:0044325]; apoptotic process [GO:0006915]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; microtubule-based transport [GO:0099111]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of aggrephagy [GO:1905337]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of cilium assembly [GO:0045724]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of lipophagy [GO:1904504]; protein destabilization [GO:0031648]; regulation of CAMKK-AMPK signaling cascade [GO:1905289]; regulation of cAMP-dependent protein kinase activity [GO:2000479]; regulation of phosphoprotein phosphatase activity [GO:0043666]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle transport along microtubule [GO:0047496]; vocal learning [GO:0042297]	SUBCELLULAR LOCATION: [Huntingtin]: Cytoplasm {ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:16476778, ECO:0000269|PubMed:7647777}. Nucleus {ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:16391387}. Early endosome {ECO:0000269|PubMed:16476778}. Note=The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner (PubMed:15654337). Recruits onto early endosomes in a Rab5- and HAP40-dependent fashion (PubMed:16476778). {ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:16476778}.; SUBCELLULAR LOCATION: [Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24459296}.
P42892	reviewed	ECE1_HUMAN	Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)	ECE1	Homo sapiens (Human)	770	FUNCTION: Converts big endothelin-1 to endothelin-1. {ECO:0000269|PubMed:9396733}.		axonogenesis involved in innervation [GO:0060385]; bradykinin catabolic process [GO:0010815]; calcitonin catabolic process [GO:0010816]; ear development [GO:0043583]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube development [GO:0035050]; endothelin maturation [GO:0034959]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; hormone catabolic process [GO:0042447]; peptide hormone processing [GO:0016486]; pharyngeal system development [GO:0060037]; positive regulation of receptor recycling [GO:0001921]; protein processing [GO:0016485]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; substance P catabolic process [GO:0010814]; sympathetic neuron axon guidance [GO:0097492]	early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093]	endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; axonogenesis involved in innervation [GO:0060385]; bradykinin catabolic process [GO:0010815]; calcitonin catabolic process [GO:0010816]; ear development [GO:0043583]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube development [GO:0035050]; endothelin maturation [GO:0034959]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; hormone catabolic process [GO:0042447]; peptide hormone processing [GO:0016486]; pharyngeal system development [GO:0060037]; positive regulation of receptor recycling [GO:0001921]; protein processing [GO:0016485]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; substance P catabolic process [GO:0010814]; sympathetic neuron axon guidance [GO:0097492]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.
P42898	reviewed	MTHR_HUMAN	Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53)	MTHFR	Homo sapiens (Human)	656	FUNCTION: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine (PubMed:29891918). Represents a key regulatory connection between the folate and methionine cycles (Probable). {ECO:0000269|PubMed:25736335, ECO:0000269|PubMed:29891918, ECO:0000305}.		heterochromatin organization [GO:0070828]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; methionine metabolic process [GO:0006555]; neural tube closure [GO:0001843]; response to amino acid [GO:0043200]; response to folic acid [GO:0051593]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; response to vitamin B2 [GO:0033274]; response to xenobiotic stimulus [GO:0009410]; S-adenosylmethionine metabolic process [GO:0046500]; tetrahydrofolate interconversion [GO:0035999]	cytosol [GO:0005829]	FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; methylenetetrahydrofolate reductase (NAD(P)H) activity [GO:0004489]; methylenetetrahydrofolate reductase NADPH activity [GO:0106313]; modified amino acid binding [GO:0072341]; NADP binding [GO:0050661]; protein-containing complex binding [GO:0044877]	cytosol [GO:0005829]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; methylenetetrahydrofolate reductase (NAD(P)H) activity [GO:0004489]; methylenetetrahydrofolate reductase NADPH activity [GO:0106313]; modified amino acid binding [GO:0072341]; NADP binding [GO:0050661]; protein-containing complex binding [GO:0044877]; heterochromatin organization [GO:0070828]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; methionine metabolic process [GO:0006555]; neural tube closure [GO:0001843]; response to amino acid [GO:0043200]; response to folic acid [GO:0051593]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; response to vitamin B2 [GO:0033274]; response to xenobiotic stimulus [GO:0009410]; S-adenosylmethionine metabolic process [GO:0046500]; tetrahydrofolate interconversion [GO:0035999]	
P43003	reviewed	EAA1_HUMAN	Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3)	SLC1A3 EAAT1 GLAST GLAST1	Homo sapiens (Human)	542	FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P56564, ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}.	MISCELLANEOUS: [Isoform 2]: Expressed throughout the CNS, both in gray matter and axonal tracts, at levels ranging between 10% and 20% of isoform 1. Localizes to ER, has no functional glutamate uptake activity, and exerts a dominant negative effect isoform 1. {ECO:0000305}.	auditory behavior [GO:0031223]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to cocaine [GO:0071314]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; cranial nerve development [GO:0021545]; D-aspartate import across plasma membrane [GO:0070779]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; intracellular sodium ion homeostasis [GO:0006883]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamate import [GO:0051938]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; neuromuscular process controlling balance [GO:0050885]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; positive regulation of synaptic transmission [GO:0050806]; potassium ion transmembrane transport [GO:0071805]; response to antibiotic [GO:0046677]; response to light stimulus [GO:0009416]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; transepithelial transport [GO:0070633]; transport across blood-brain barrier [GO:0150104]	basal plasma membrane [GO:0009925]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; membrane protein complex [GO:0098796]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]	glutamate binding [GO:0016595]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	basal plasma membrane [GO:0009925]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; membrane protein complex [GO:0098796]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; glutamate binding [GO:0016595]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; auditory behavior [GO:0031223]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to cocaine [GO:0071314]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; cranial nerve development [GO:0021545]; D-aspartate import across plasma membrane [GO:0070779]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; intracellular sodium ion homeostasis [GO:0006883]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamate import [GO:0051938]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; neuromuscular process controlling balance [GO:0050885]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; positive regulation of synaptic transmission [GO:0050806]; potassium ion transmembrane transport [GO:0071805]; response to antibiotic [GO:0046677]; response to light stimulus [GO:0009416]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; transepithelial transport [GO:0070633]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}; Multi-pass membrane protein {ECO:0000269|PubMed:28424515}.
P43004	reviewed	EAA2_HUMAN	Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)	SLC1A2 EAAT2 GLT1	Homo sapiens (Human)	574	FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P43006, ECO:0000269|PubMed:15265858, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911}.		adult behavior [GO:0030534]; cellular response to cocaine [GO:0071314]; cellular response to extracellular stimulus [GO:0031668]; chemical synaptic transmission [GO:0007268]; D-aspartate import across plasma membrane [GO:0070779]; glutathione biosynthetic process [GO:0006750]; L-aspartate import across plasma membrane [GO:0140009]; L-aspartate transmembrane transport [GO:0070778]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; multicellular organism growth [GO:0035264]; neurotransmitter reuptake [GO:0098810]; neurotransmitter transport [GO:0006836]; positive regulation of glucose import [GO:0046326]; protein homotrimerization [GO:0070207]; response to amino acid [GO:0043200]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; telencephalon development [GO:0021537]; transepithelial transport [GO:0070633]; transport across blood-brain barrier [GO:0150104]; visual behavior [GO:0007632]	astrocyte projection [GO:0097449]; axolemma [GO:0030673]; cell body [GO:0044297]; cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; membrane protein complex [GO:0098796]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; vesicle [GO:0031982]	cysteine transmembrane transporter activity [GO:0033229]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; monoatomic anion transmembrane transporter activity [GO:0008509]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	astrocyte projection [GO:0097449]; axolemma [GO:0030673]; cell body [GO:0044297]; cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; membrane protein complex [GO:0098796]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; vesicle [GO:0031982]; cysteine transmembrane transporter activity [GO:0033229]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; monoatomic anion transmembrane transporter activity [GO:0008509]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; adult behavior [GO:0030534]; cellular response to cocaine [GO:0071314]; cellular response to extracellular stimulus [GO:0031668]; chemical synaptic transmission [GO:0007268]; D-aspartate import across plasma membrane [GO:0070779]; glutathione biosynthetic process [GO:0006750]; L-aspartate import across plasma membrane [GO:0140009]; L-aspartate transmembrane transport [GO:0070778]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; multicellular organism growth [GO:0035264]; neurotransmitter reuptake [GO:0098810]; neurotransmitter transport [GO:0006836]; positive regulation of glucose import [GO:0046326]; protein homotrimerization [GO:0070207]; response to amino acid [GO:0043200]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; telencephalon development [GO:0021537]; transepithelial transport [GO:0070633]; transport across blood-brain barrier [GO:0150104]; visual behavior [GO:0007632]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14506254, ECO:0000269|PubMed:15265858, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911}; Multi-pass membrane protein {ECO:0000305}.
P43005	reviewed	EAA3_HUMAN	Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1)	SLC1A1 EAAC1 EAAT3 HEAAC1	Homo sapiens (Human)	524	FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949, PubMed:33658209). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:33658209). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity). {ECO:0000250|UniProtKB:P51906, ECO:0000250|UniProtKB:P51907, ECO:0000269|PubMed:21123949, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:33658209, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7914198, ECO:0000269|PubMed:8857541}.		adult behavior [GO:0030534]; behavioral fear response [GO:0001662]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; cellular response to ammonium ion [GO:0071242]; cellular response to bisphenol A [GO:1903926]; cellular response to cocaine [GO:0071314]; cellular response to mercury ion [GO:0071288]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; conditioned place preference [GO:1990708]; cysteine transport [GO:0042883]; cytokine-mediated signaling pathway [GO:0019221]; D-aspartate import across plasma membrane [GO:0070779]; D-aspartate transport [GO:0070777]; dopamine metabolic process [GO:0042417]; dopamine receptor signaling pathway [GO:0007212]; gene expression [GO:0010467]; glutamate receptor signaling pathway [GO:0007215]; glutathione biosynthetic process [GO:0006750]; grooming behavior [GO:0007625]; heart contraction [GO:0060047]; intracellular glutamate homeostasis [GO:0090461]; intracellular zinc ion homeostasis [GO:0006882]; L-aspartate import across plasma membrane [GO:0140009]; L-aspartate transmembrane transport [GO:0070778]; L-glutamate import [GO:0051938]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; locomotory behavior [GO:0007626]; long-term synaptic potentiation [GO:0060291]; maintenance of blood-brain barrier [GO:0035633]; memory [GO:0007613]; monoatomic ion transport [GO:0006811]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; neurotransmitter receptor transport to plasma membrane [GO:0098877]; neurotransmitter transport [GO:0006836]; positive regulation of heart rate [GO:0010460]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of protein phosphorylation [GO:0001932]; regulation of protein targeting to membrane [GO:0090313]; response to amphetamine [GO:0001975]; response to anesthetic [GO:0072347]; response to axon injury [GO:0048678]; response to decreased oxygen levels [GO:0036293]; response to morphine [GO:0043278]; response to xenobiotic stimulus [GO:0009410]; retina layer formation [GO:0010842]; righting reflex [GO:0060013]; superoxide metabolic process [GO:0006801]; synapse organization [GO:0050808]; transepithelial transport [GO:0070633]; transport across blood-brain barrier [GO:0150104]; zinc ion transmembrane transport [GO:0071577]	apical dendrite [GO:0097440]; apical plasma membrane [GO:0016324]; asymmetric synapse [GO:0032279]; axon [GO:0030424]; axon terminus [GO:0043679]; cell periphery [GO:0071944]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; distal dendrite [GO:0150002]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perisynaptic space [GO:0099544]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; proximal dendrite [GO:1990635]; recycling endosome membrane [GO:0055038]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic cleft [GO:0043083]	chloride transmembrane transporter activity [GO:0015108]; cysteine transmembrane transporter activity [GO:0033229]; D-aspartate transmembrane transporter activity [GO:0140010]; glutamate binding [GO:0016595]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; monoatomic anion channel activity [GO:0005253]	apical dendrite [GO:0097440]; apical plasma membrane [GO:0016324]; asymmetric synapse [GO:0032279]; axon [GO:0030424]; axon terminus [GO:0043679]; cell periphery [GO:0071944]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; distal dendrite [GO:0150002]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perisynaptic space [GO:0099544]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; proximal dendrite [GO:1990635]; recycling endosome membrane [GO:0055038]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic cleft [GO:0043083]; chloride transmembrane transporter activity [GO:0015108]; cysteine transmembrane transporter activity [GO:0033229]; D-aspartate transmembrane transporter activity [GO:0140010]; glutamate binding [GO:0016595]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; monoatomic anion channel activity [GO:0005253]; adult behavior [GO:0030534]; behavioral fear response [GO:0001662]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; cellular response to ammonium ion [GO:0071242]; cellular response to bisphenol A [GO:1903926]; cellular response to cocaine [GO:0071314]; cellular response to mercury ion [GO:0071288]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; conditioned place preference [GO:1990708]; cysteine transport [GO:0042883]; cytokine-mediated signaling pathway [GO:0019221]; D-aspartate import across plasma membrane [GO:0070779]; D-aspartate transport [GO:0070777]; dopamine metabolic process [GO:0042417]; dopamine receptor signaling pathway [GO:0007212]; gene expression [GO:0010467]; glutamate receptor signaling pathway [GO:0007215]; glutathione biosynthetic process [GO:0006750]; grooming behavior [GO:0007625]; heart contraction [GO:0060047]; intracellular glutamate homeostasis [GO:0090461]; intracellular zinc ion homeostasis [GO:0006882]; L-aspartate import across plasma membrane [GO:0140009]; L-aspartate transmembrane transport [GO:0070778]; L-glutamate import [GO:0051938]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; locomotory behavior [GO:0007626]; long-term synaptic potentiation [GO:0060291]; maintenance of blood-brain barrier [GO:0035633]; memory [GO:0007613]; monoatomic ion transport [GO:0006811]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; neurotransmitter receptor transport to plasma membrane [GO:0098877]; neurotransmitter transport [GO:0006836]; positive regulation of heart rate [GO:0010460]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of protein phosphorylation [GO:0001932]; regulation of protein targeting to membrane [GO:0090313]; response to amphetamine [GO:0001975]; response to anesthetic [GO:0072347]; response to axon injury [GO:0048678]; response to decreased oxygen levels [GO:0036293]; response to morphine [GO:0043278]; response to xenobiotic stimulus [GO:0009410]; retina layer formation [GO:0010842]; righting reflex [GO:0060013]; superoxide metabolic process [GO:0006801]; synapse organization [GO:0050808]; transepithelial transport [GO:0070633]; transport across blood-brain barrier [GO:0150104]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21123949, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7914198, ECO:0000269|PubMed:8857541}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43003}. Apical cell membrane {ECO:0000269|PubMed:21123949}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43003}. Synapse, synaptosome {ECO:0000250|UniProtKB:P51906}. Early endosome membrane {ECO:0000250|UniProtKB:P51906}. Late endosome membrane {ECO:0000250|UniProtKB:P51906}. Recycling endosome membrane {ECO:0000250|UniProtKB:P51906}.
P43007	reviewed	SATT_HUMAN	Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (Solute carrier family 1 member 4)	SLC1A4 ASCT1 SATT	Homo sapiens (Human)	532	FUNCTION: Sodium-dependent neutral amino-acid transporter that mediates transport of alanine, serine, cysteine, proline, hydroxyproline and threonine. {ECO:0000269|PubMed:14502423, ECO:0000269|PubMed:26041762, ECO:0000269|PubMed:8101838, ECO:0000269|PubMed:8340364}.		amino acid transport [GO:0006865]; cognition [GO:0050890]; glutamine transport [GO:0006868]; hydroxyproline transport [GO:0034589]; L-alanine import across plasma membrane [GO:1904273]; L-alanine transport [GO:0015808]; L-aspartate import across plasma membrane [GO:0140009]; L-cystine transport [GO:0015811]; L-glutamate transmembrane transport [GO:0015813]; L-serine import across plasma membrane [GO:1903812]; L-serine transport [GO:0015825]; proline transport [GO:0015824]; synaptic transmission, glutamatergic [GO:0035249]; threonine transport [GO:0015826]; transport across blood-brain barrier [GO:0150104]	cell surface [GO:0009986]; centrosome [GO:0005813]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	amino acid transmembrane transporter activity [GO:0015171]; chloride channel activity [GO:0005254]; L-alanine transmembrane transporter activity [GO:0015180]; L-aspartate transmembrane transporter activity [GO:0015183]; L-cystine transmembrane transporter activity [GO:0015184]; L-glutamine transmembrane transporter activity [GO:0015186]; L-hydroxyproline transmembrane transporter activity [GO:0034590]; L-proline transmembrane transporter activity [GO:0015193]; L-serine transmembrane transporter activity [GO:0015194]; L-threonine transmembrane transporter activity [GO:0015195]; symporter activity [GO:0015293]	cell surface [GO:0009986]; centrosome [GO:0005813]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; amino acid transmembrane transporter activity [GO:0015171]; chloride channel activity [GO:0005254]; L-alanine transmembrane transporter activity [GO:0015180]; L-aspartate transmembrane transporter activity [GO:0015183]; L-cystine transmembrane transporter activity [GO:0015184]; L-glutamine transmembrane transporter activity [GO:0015186]; L-hydroxyproline transmembrane transporter activity [GO:0034590]; L-proline transmembrane transporter activity [GO:0015193]; L-serine transmembrane transporter activity [GO:0015194]; L-threonine transmembrane transporter activity [GO:0015195]; symporter activity [GO:0015293]; amino acid transport [GO:0006865]; cognition [GO:0050890]; glutamine transport [GO:0006868]; hydroxyproline transport [GO:0034589]; L-alanine import across plasma membrane [GO:1904273]; L-alanine transport [GO:0015808]; L-aspartate import across plasma membrane [GO:0140009]; L-cystine transport [GO:0015811]; L-glutamate transmembrane transport [GO:0015813]; L-serine import across plasma membrane [GO:1903812]; L-serine transport [GO:0015825]; proline transport [GO:0015824]; synaptic transmission, glutamatergic [GO:0035249]; threonine transport [GO:0015826]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17081065}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.
P43026	reviewed	GDF5_HUMAN	Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)	GDF5 BMP14 CDMP1	Homo sapiens (Human)	501	FUNCTION: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). {ECO:0000250|UniProtKB:P43027, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:15530414, ECO:0000269|PubMed:19229295, ECO:0000269|PubMed:19956691, ECO:0000269|PubMed:21976273, ECO:0000269|PubMed:24098149, ECO:0000269|PubMed:25092592}.		cell-cell signaling [GO:0007267]; chondroblast differentiation [GO:0060591]; chondrocyte differentiation [GO:0002062]; embryonic limb morphogenesis [GO:0030326]; forelimb morphogenesis [GO:0035136]; hindlimb morphogenesis [GO:0035137]; mesenchymal cell apoptotic process [GO:0097152]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of neuron apoptotic process [GO:0043524]; ossification involved in bone remodeling [GO:0043932]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of neuron differentiation [GO:0045666]; regulation of multicellular organism growth [GO:0040014]; regulation of SMAD protein signal transduction [GO:0060390]; response to mechanical stimulus [GO:0009612]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	BMP binding [GO:0036122]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; BMP binding [GO:0036122]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; cell-cell signaling [GO:0007267]; chondroblast differentiation [GO:0060591]; chondrocyte differentiation [GO:0002062]; embryonic limb morphogenesis [GO:0030326]; forelimb morphogenesis [GO:0035136]; hindlimb morphogenesis [GO:0035137]; mesenchymal cell apoptotic process [GO:0097152]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of neuron apoptotic process [GO:0043524]; ossification involved in bone remodeling [GO:0043932]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of neuron differentiation [GO:0045666]; regulation of multicellular organism growth [GO:0040014]; regulation of SMAD protein signal transduction [GO:0060390]; response to mechanical stimulus [GO:0009612]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11276205}. Cell membrane {ECO:0000269|PubMed:11276205}.
P43034	reviewed	LIS1_HUMAN	Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)	PAFAH1B1 LIS1 MDCR MDS PAFAHA	Homo sapiens (Human)	410	FUNCTION: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). {ECO:0000250|UniProtKB:P43033, ECO:0000250|UniProtKB:P63005, ECO:0000269|PubMed:15173193, ECO:0000269|PubMed:22956769}.	MISCELLANEOUS: Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity) (Ref.4). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity). {ECO:0000250|UniProtKB:P68402, ECO:0000250|UniProtKB:Q15102, ECO:0000250|UniProtKB:Q29460, ECO:0000303|Ref.4}.	acrosome assembly [GO:0001675]; actin cytoskeleton organization [GO:0030036]; adult locomotory behavior [GO:0008344]; ameboidal-type cell migration [GO:0001667]; auditory receptor cell development [GO:0060117]; brain morphogenesis [GO:0048854]; cerebral cortex development [GO:0021987]; cerebral cortex neuron differentiation [GO:0021895]; chemical synaptic transmission [GO:0007268]; cochlea development [GO:0090102]; corpus callosum morphogenesis [GO:0021540]; cortical microtubule organization [GO:0043622]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; establishment of planar polarity of embryonic epithelium [GO:0042249]; germ cell development [GO:0007281]; hippocampus development [GO:0021766]; interneuron migration [GO:1904936]; JNK cascade [GO:0007254]; layer formation in cerebral cortex [GO:0021819]; learning or memory [GO:0007611]; lipid catabolic process [GO:0016042]; maintenance of centrosome location [GO:0051661]; microtubule cytoskeleton organization [GO:0000226]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; microtubule organizing center organization [GO:0031023]; microtubule sliding [GO:0051012]; microtubule-based process [GO:0007017]; modulation of chemical synaptic transmission [GO:0050804]; myeloid leukocyte migration [GO:0097529]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neuron projection development [GO:0010977]; neuroblast proliferation [GO:0007405]; neuromuscular process controlling balance [GO:0050885]; neuron migration [GO:0001764]; nuclear membrane disassembly [GO:0051081]; nuclear migration [GO:0007097]; osteoclast development [GO:0036035]; platelet activating factor metabolic process [GO:0046469]; positive regulation of axon extension [GO:0045773]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of embryonic development [GO:0040019]; positive regulation of mitotic cell cycle [GO:0045931]; protein secretion [GO:0009306]; radial glia-guided pyramidal neuron migration [GO:0140650]; reelin-mediated signaling pathway [GO:0038026]; regulation of microtubule cytoskeleton organization [GO:0070507]; retrograde axonal transport [GO:0008090]; stem cell division [GO:0017145]; transmission of nerve impulse [GO:0019226]; vesicle transport along microtubule [GO:0047496]	1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; astral microtubule [GO:0000235]; axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; central region of growth cone [GO:0090724]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule associated complex [GO:0005875]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; Schaffer collateral - CA1 synapse [GO:0098685]; stereocilium [GO:0032420]	dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein intermediate chain binding [GO:0045505]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; phospholipase binding [GO:0043274]; phosphoprotein binding [GO:0051219]; protein heterodimerization activity [GO:0046982]	1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; astral microtubule [GO:0000235]; axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; central region of growth cone [GO:0090724]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule associated complex [GO:0005875]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; Schaffer collateral - CA1 synapse [GO:0098685]; stereocilium [GO:0032420]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein intermediate chain binding [GO:0045505]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; phospholipase binding [GO:0043274]; phosphoprotein binding [GO:0051219]; protein heterodimerization activity [GO:0046982]; acrosome assembly [GO:0001675]; actin cytoskeleton organization [GO:0030036]; adult locomotory behavior [GO:0008344]; ameboidal-type cell migration [GO:0001667]; auditory receptor cell development [GO:0060117]; brain morphogenesis [GO:0048854]; cerebral cortex development [GO:0021987]; cerebral cortex neuron differentiation [GO:0021895]; chemical synaptic transmission [GO:0007268]; cochlea development [GO:0090102]; corpus callosum morphogenesis [GO:0021540]; cortical microtubule organization [GO:0043622]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; establishment of planar polarity of embryonic epithelium [GO:0042249]; germ cell development [GO:0007281]; hippocampus development [GO:0021766]; interneuron migration [GO:1904936]; JNK cascade [GO:0007254]; layer formation in cerebral cortex [GO:0021819]; learning or memory [GO:0007611]; lipid catabolic process [GO:0016042]; maintenance of centrosome location [GO:0051661]; microtubule cytoskeleton organization [GO:0000226]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; microtubule organizing center organization [GO:0031023]; microtubule sliding [GO:0051012]; microtubule-based process [GO:0007017]; modulation of chemical synaptic transmission [GO:0050804]; myeloid leukocyte migration [GO:0097529]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neuron projection development [GO:0010977]; neuroblast proliferation [GO:0007405]; neuromuscular process controlling balance [GO:0050885]; neuron migration [GO:0001764]; nuclear membrane disassembly [GO:0051081]; nuclear migration [GO:0007097]; osteoclast development [GO:0036035]; platelet activating factor metabolic process [GO:0046469]; positive regulation of axon extension [GO:0045773]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of embryonic development [GO:0040019]; positive regulation of mitotic cell cycle [GO:0045931]; protein secretion [GO:0009306]; radial glia-guided pyramidal neuron migration [GO:0140650]; reelin-mediated signaling pathway [GO:0038026]; regulation of microtubule cytoskeleton organization [GO:0070507]; retrograde axonal transport [GO:0008090]; stem cell division [GO:0017145]; transmission of nerve impulse [GO:0019226]; vesicle transport along microtubule [GO:0047496]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, spindle {ECO:0000255|HAMAP-Rule:MF_03141}. Nucleus membrane {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes (By similarity). Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. {ECO:0000250}.
P43080	reviewed	GUC1A_HUMAN	Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A)	GUCA1A C6orf131 GCAP GCAP1 GUCA1	Homo sapiens (Human)	201	FUNCTION: Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:19459154, PubMed:30622141, PubMed:18706439, PubMed:30184081). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity). {ECO:0000250|UniProtKB:P43081, ECO:0000250|UniProtKB:P46065, ECO:0000269|PubMed:18706439, ECO:0000269|PubMed:30184081, ECO:0000269|PubMed:30622141}.		cellular response to calcium ion [GO:0071277]; phototransduction [GO:0007602]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of guanylate cyclase activity [GO:0031284]; signal transduction [GO:0007165]; visual perception [GO:0007601]	cone photoreceptor outer segment [GO:0120199]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]	calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]; guanylate cyclase regulator activity [GO:0030249]	cone photoreceptor outer segment [GO:0120199]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]; guanylate cyclase regulator activity [GO:0030249]; cellular response to calcium ion [GO:0071277]; phototransduction [GO:0007602]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of guanylate cyclase activity [GO:0031284]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane; Lipid-anchor {ECO:0000250|UniProtKB:P46065}. Photoreceptor inner segment {ECO:0000269|PubMed:9620085}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:9620085}. Note=Present at higher levels in cone than in rod outer segments (PubMed:9620085). Subcellular location is not affected by light or dark conditions. {ECO:0000269|PubMed:9620085}.
P43088	reviewed	PF2R_HUMAN	Prostaglandin F2-alpha receptor (PGF receptor) (PGF2-alpha receptor) (Prostanoid FP receptor)	PTGFR	Homo sapiens (Human)	359	FUNCTION: Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost. {ECO:0000250, ECO:0000269|PubMed:18587449}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cellular response to prostaglandin D stimulus [GO:0071799]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; parturition [GO:0007567]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	prostaglandin F receptor activity [GO:0004958]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; prostaglandin F receptor activity [GO:0004958]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cellular response to prostaglandin D stimulus [GO:0071799]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; parturition [GO:0007567]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P43115	reviewed	PE2R3_HUMAN	Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)	PTGER3	Homo sapiens (Human)	390	FUNCTION: Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity). {ECO:0000250|UniProtKB:P30557, ECO:0000269|PubMed:7883006, ECO:0000269|PubMed:7981210, ECO:0000269|PubMed:8117308, ECO:0000269|PubMed:8135729, ECO:0000269|PubMed:8307176}.	MISCELLANEOUS: [Isoform EP3C]: Known as EP3D in PubMed:8075855. {ECO:0000305}.; MISCELLANEOUS: [Isoform EP3B]: Known as EP3E in PubMed:8075855. {ECO:0000305}.; MISCELLANEOUS: [Isoform EP3D]: Known as EP3F in PubMed:8075855. {ECO:0000305}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell death [GO:0008219]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intestine smooth muscle contraction [GO:0014827]; negative regulation of gastric acid secretion [GO:0060455]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fever generation [GO:0031622]	membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; prostaglandin E receptor activity [GO:0004957]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell death [GO:0008219]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intestine smooth muscle contraction [GO:0014827]; negative regulation of gastric acid secretion [GO:0060455]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fever generation [GO:0031622]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7883006, ECO:0000269|PubMed:7981210, ECO:0000269|PubMed:8117308, ECO:0000269|PubMed:8307176}; Multi-pass membrane protein {ECO:0000305}.
P43119	reviewed	PI2R_HUMAN	Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)	PTGIR PRIPR	Homo sapiens (Human)	386	FUNCTION: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inflammatory response [GO:0006954]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to lipopolysaccharide [GO:0032496]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; prostacyclin receptor activity [GO:0016501]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; prostacyclin receptor activity [GO:0016501]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inflammatory response [GO:0006954]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P43121	reviewed	MUC18_HUMAN	Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)	MCAM MUC18	Homo sapiens (Human)	646	FUNCTION: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}.		anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; glomerular filtration [GO:0003094]; positive regulation of cell migration [GO:0030335]; vascular wound healing [GO:0061042]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]		external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; glomerular filtration [GO:0003094]; positive regulation of cell migration [GO:0030335]; vascular wound healing [GO:0061042]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P43146	reviewed	DCC_HUMAN	Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC)	DCC IGDCC1	Homo sapiens (Human)	1447	FUNCTION: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}.	MISCELLANEOUS: Inactivation of DCC due to allelic deletion and/or point mutations is related to lymphatic and hematogenous metastatic tumor dissemination.	anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cell-cell adhesion [GO:0098609]; dorsal/ventral axon guidance [GO:0033563]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendrite development [GO:2000171]; negative regulation of neuron projection development [GO:0010977]; neuron migration [GO:0001764]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; spinal cord ventral commissure morphogenesis [GO:0021965]	axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]	transmembrane signaling receptor activity [GO:0004888]	axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; transmembrane signaling receptor activity [GO:0004888]; anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cell-cell adhesion [GO:0098609]; dorsal/ventral axon guidance [GO:0033563]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendrite development [GO:2000171]; negative regulation of neuron projection development [GO:0010977]; neuron migration [GO:0001764]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; spinal cord ventral commissure morphogenesis [GO:0021965]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P43155	reviewed	CACP_HUMAN	Carnitine O-acetyltransferase (Carnitine acetylase) (EC 2.3.1.137) (EC 2.3.1.7) (Carnitine acetyltransferase) (CAT) (CrAT)	CRAT CAT1	Homo sapiens (Human)	626	FUNCTION: Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation (PubMed:15099582, PubMed:29395073). Responsible for the synthesis of short- and branched-chain acylcarnitines (PubMed:23485643). Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates (PubMed:23485643). Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates (PubMed:23485643). {ECO:0000269|PubMed:15099582, ECO:0000269|PubMed:23485643, ECO:0000269|PubMed:29395073}.		carnitine metabolic process, CoA-linked [GO:0019254]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; medium-chain fatty acid metabolic process [GO:0051791]; short-chain fatty acid metabolic process [GO:0046459]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	acyl-CoA oxidase activity [GO:0003997]; carnitine O-acetyltransferase activity [GO:0004092]; carnitine O-octanoyltransferase activity [GO:0008458]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; acyl-CoA oxidase activity [GO:0003997]; carnitine O-acetyltransferase activity [GO:0004092]; carnitine O-octanoyltransferase activity [GO:0008458]; carnitine metabolic process, CoA-linked [GO:0019254]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; medium-chain fatty acid metabolic process [GO:0051791]; short-chain fatty acid metabolic process [GO:0046459]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000305}. Peroxisome {ECO:0000305}. Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000305|PubMed:23485643}.; SUBCELLULAR LOCATION: [Isoform 2]: Peroxisome {ECO:0000305|PubMed:23485643}.
P43166	reviewed	CAH7_HUMAN	Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII)	CA7	Homo sapiens (Human)	264	FUNCTION: Reversible hydration of carbon dioxide.		neuron cellular homeostasis [GO:0070050]; one-carbon metabolic process [GO:0006730]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of chloride transport [GO:2001225]; regulation of intracellular pH [GO:0051453]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]; neuron cellular homeostasis [GO:0070050]; one-carbon metabolic process [GO:0006730]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of chloride transport [GO:2001225]; regulation of intracellular pH [GO:0051453]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P43220	reviewed	GLP1R_HUMAN	Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R)	GLP1R	Homo sapiens (Human)	463	FUNCTION: G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). {ECO:0000250|UniProtKB:O35659, ECO:0000269|PubMed:19861722, ECO:0000269|PubMed:26308095, ECO:0000269|PubMed:27196125, ECO:0000269|PubMed:28514449, ECO:0000269|PubMed:7517895, ECO:0000269|PubMed:8216285, ECO:0000269|PubMed:8405712}.		activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP-mediated signaling [GO:0019933]; cell surface receptor signaling pathway [GO:0007166]; hormone secretion [GO:0046879]; learning or memory [GO:0007611]; negative regulation of blood pressure [GO:0045776]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; post-translational protein targeting to membrane, translocation [GO:0031204]; regulation of heart contraction [GO:0008016]; response to psychosocial stress [GO:1990911]	membrane [GO:0016020]; plasma membrane [GO:0005886]	glucagon receptor activity [GO:0004967]; glucagon-like peptide 1 receptor activity [GO:0044508]; peptide hormone binding [GO:0017046]; transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; plasma membrane [GO:0005886]; glucagon receptor activity [GO:0004967]; glucagon-like peptide 1 receptor activity [GO:0044508]; peptide hormone binding [GO:0017046]; transmembrane signaling receptor activity [GO:0004888]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP-mediated signaling [GO:0019933]; cell surface receptor signaling pathway [GO:0007166]; hormone secretion [GO:0046879]; learning or memory [GO:0007611]; negative regulation of blood pressure [GO:0045776]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; post-translational protein targeting to membrane, translocation [GO:0031204]; regulation of heart contraction [GO:0008016]; response to psychosocial stress [GO:1990911]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19861722, ECO:0000269|PubMed:26308095, ECO:0000269|PubMed:27196125, ECO:0000269|PubMed:28514449, ECO:0000269|PubMed:7517895, ECO:0000269|PubMed:8216285, ECO:0000269|PubMed:8405712}; Multi-pass membrane protein {ECO:0000269|PubMed:28514449}.
P43234	reviewed	CATO_HUMAN	Cathepsin O (EC 3.4.22.42)	CTSO CTSO1	Homo sapiens (Human)	321	FUNCTION: Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.		proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]	extracellular space [GO:0005615]; lysosome [GO:0005764]	cysteine-type endopeptidase activity [GO:0004197]	extracellular space [GO:0005615]; lysosome [GO:0005764]; cysteine-type endopeptidase activity [GO:0004197]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]	SUBCELLULAR LOCATION: Lysosome.
P43235	reviewed	CATK_HUMAN	Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X)	CTSK CTSO CTSO2	Homo sapiens (Human)	329	FUNCTION: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042). {ECO:0000269|PubMed:11082042}.		autophagy of mitochondrion [GO:0000422]; bone resorption [GO:0045453]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to zinc ion starvation [GO:0034224]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; intramembranous ossification [GO:0001957]; mononuclear cell differentiation [GO:1903131]; negative regulation of cartilage development [GO:0061037]; positive regulation of apoptotic signaling pathway [GO:2001235]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070]; thyroid hormone generation [GO:0006590]	apical plasma membrane [GO:0016324]; endolysosome lumen [GO:0036021]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]	collagen binding [GO:0005518]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; fibronectin binding [GO:0001968]; proteoglycan binding [GO:0043394]; serine-type endopeptidase activity [GO:0004252]	apical plasma membrane [GO:0016324]; endolysosome lumen [GO:0036021]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; collagen binding [GO:0005518]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; fibronectin binding [GO:0001968]; proteoglycan binding [GO:0043394]; serine-type endopeptidase activity [GO:0004252]; autophagy of mitochondrion [GO:0000422]; bone resorption [GO:0045453]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to zinc ion starvation [GO:0034224]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; intramembranous ossification [GO:0001957]; mononuclear cell differentiation [GO:1903131]; negative regulation of cartilage development [GO:0061037]; positive regulation of apoptotic signaling pathway [GO:2001235]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070]; thyroid hormone generation [GO:0006590]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:11082042}. Secreted {ECO:0000269|PubMed:11082042}. Apical cell membrane {ECO:0000269|PubMed:11082042}; Peripheral membrane protein {ECO:0000269|PubMed:11082042}; Extracellular side {ECO:0000269|PubMed:11082042}. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. {ECO:0000269|PubMed:11082042}.
P43243	reviewed	MATR3_HUMAN	Matrin-3	MATR3 KIAA0723	Homo sapiens (Human)	847	FUNCTION: May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}.		activation of innate immune response [GO:0002218]; blastocyst formation [GO:0001825]; heart valve development [GO:0003170]; innate immune response [GO:0045087]; post-transcriptional regulation of gene expression [GO:0010608]; ventricular septum development [GO:0003281]	membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; activation of innate immune response [GO:0002218]; blastocyst formation [GO:0001825]; heart valve development [GO:0003170]; innate immune response [GO:0045087]; post-transcriptional regulation of gene expression [GO:0010608]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Nucleus matrix.
P43246	reviewed	MSH2_HUMAN	DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2)	MSH2	Homo sapiens (Human)	934	FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:17611581, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:26300262, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}.		B cell differentiation [GO:0030183]; B cell mediated immunity [GO:0019724]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; germ cell development [GO:0007281]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; isotype switching [GO:0045190]; maintenance of DNA repeat elements [GO:0043570]; male gonad development [GO:0008584]; mismatch repair [GO:0006298]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; mitotic recombination [GO:0006312]; negative regulation of DNA recombination [GO:0045910]; negative regulation of neuron apoptotic process [GO:0043524]; oxidative phosphorylation [GO:0006119]; positive regulation of helicase activity [GO:0051096]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; postreplication repair [GO:0006301]; protein localization to chromatin [GO:0071168]; response to UV-B [GO:0010224]; response to X-ray [GO:0010165]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]; somatic recombination of immunoglobulin genes involved in immune response [GO:0002204]	chromosome, telomeric region [GO:0000781]; membrane [GO:0016020]; MutSalpha complex [GO:0032301]; MutSbeta complex [GO:0032302]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; guanine/thymine mispair binding [GO:0032137]; protein homodimerization activity [GO:0042803]	chromosome, telomeric region [GO:0000781]; membrane [GO:0016020]; MutSalpha complex [GO:0032301]; MutSbeta complex [GO:0032302]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; guanine/thymine mispair binding [GO:0032137]; protein homodimerization activity [GO:0042803]; B cell differentiation [GO:0030183]; B cell mediated immunity [GO:0019724]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; germ cell development [GO:0007281]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; isotype switching [GO:0045190]; maintenance of DNA repeat elements [GO:0043570]; male gonad development [GO:0008584]; mismatch repair [GO:0006298]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; mitotic recombination [GO:0006312]; negative regulation of DNA recombination [GO:0045910]; negative regulation of neuron apoptotic process [GO:0043524]; oxidative phosphorylation [GO:0006119]; positive regulation of helicase activity [GO:0051096]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; postreplication repair [GO:0006301]; protein localization to chromatin [GO:0071168]; response to UV-B [GO:0010224]; response to X-ray [GO:0010165]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]; somatic recombination of immunoglobulin genes involved in immune response [GO:0002204]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26300262}. Chromosome {ECO:0000269|PubMed:26300262}.
P43250	reviewed	GRK6_HUMAN	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)	GRK6 GPRK6	Homo sapiens (Human)	576	FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}.		G protein-coupled receptor signaling pathway [GO:0007186]; phosphorylation [GO:0016310]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of signal transduction [GO:0009966]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; G protein-coupled receptor kinase activity [GO:0004703]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; G protein-coupled receptor kinase activity [GO:0004703]; G protein-coupled receptor signaling pathway [GO:0007186]; phosphorylation [GO:0016310]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of signal transduction [GO:0009966]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
P43251	reviewed	BTD_HUMAN	Biotinidase (Biotinase) (EC 3.5.1.12)	BTD	Homo sapiens (Human)	543	FUNCTION: Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. {ECO:0000305|PubMed:9099842, ECO:0000305|PubMed:9654207}.		biotin metabolic process [GO:0006768]; central nervous system development [GO:0007417]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]	biotinidase activity [GO:0047708]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; biotinidase activity [GO:0047708]; biotin metabolic process [GO:0006768]; central nervous system development [GO:0007417]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000305|PubMed:9099842, ECO:0000305|PubMed:9654207}.
P43268	reviewed	ETV4_HUMAN	ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3)	ETV4 E1AF PEA3	Homo sapiens (Human)	484	FUNCTION: Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:8441666}.		positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
P43304	reviewed	GPDM_HUMAN	Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) (mitohondrial glycerophosphate dehydrogenase gene) (mGDH) (mtGPD)	GPD2	Homo sapiens (Human)	727	FUNCTION: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. {ECO:0000269|PubMed:9070847}.		glycerol catabolic process [GO:0019563]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerophosphate shuttle [GO:0006127]	glycerol-3-phosphate dehydrogenase complex [GO:0009331]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	calcium ion binding [GO:0005509]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity [GO:0052591]	glycerol-3-phosphate dehydrogenase complex [GO:0009331]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; calcium ion binding [GO:0005509]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity [GO:0052591]; glycerol catabolic process [GO:0019563]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerophosphate shuttle [GO:0006127]	SUBCELLULAR LOCATION: Mitochondrion.
P43307	reviewed	SSRA_HUMAN	Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha)	SSR1 TRAPA PSEC0262	Homo sapiens (Human)	286	FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.	MISCELLANEOUS: Seems to bind calcium.	cotranslational protein targeting to membrane [GO:0006613]; positive regulation of cell population proliferation [GO:0008284]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; cotranslational protein targeting to membrane [GO:0006613]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
P43320	reviewed	CRBB2_HUMAN	Beta-crystallin B2 (Beta-B2 crystallin) (Beta-crystallin Bp)	CRYBB2 CRYB2 CRYB2A	Homo sapiens (Human)	205	FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.		lens development in camera-type eye [GO:0002088]; response to stimulus [GO:0050896]; visual perception [GO:0007601]		identical protein binding [GO:0042802]; structural constituent of eye lens [GO:0005212]; structural molecule activity [GO:0005198]	identical protein binding [GO:0042802]; structural constituent of eye lens [GO:0005212]; structural molecule activity [GO:0005198]; lens development in camera-type eye [GO:0002088]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	
P43351	reviewed	RAD52_HUMAN	DNA repair protein RAD52 homolog	RAD52	Homo sapiens (Human)	418	FUNCTION: Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. {ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:8702565}.	MISCELLANEOUS: [Isoform beta]: Unable to interact with isoform alpha, may act as dominant negative. {ECO:0000305}.; MISCELLANEOUS: [Isoform gamma]: Unable to interact with isoform alpha, may act as dominant negative. {ECO:0000305}.; MISCELLANEOUS: [Isoform delta]: Unable to interact with isoform alpha, may act as dominant negative. {ECO:0000305}.	cellular response to oxidative stress [GO:0034599]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA recombinase assembly [GO:0000730]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via single-strand annealing [GO:0045002]; mitotic recombination [GO:0006312]; regulation of nucleotide-excision repair [GO:2000819]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]; cellular response to oxidative stress [GO:0034599]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA recombinase assembly [GO:0000730]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via single-strand annealing [GO:0045002]; mitotic recombination [GO:0006312]; regulation of nucleotide-excision repair [GO:2000819]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P43353	reviewed	AL3B1_HUMAN	Aldehyde dehydrogenase family 3 member B1 (EC 1.2.1.28) (EC 1.2.1.5) (EC 1.2.1.7) (Aldehyde dehydrogenase 7)	ALDH3B1 ALDH7	Homo sapiens (Human)	468	FUNCTION: Oxidizes medium and long chain saturated and unsaturated aldehydes (PubMed:17382292, PubMed:23721920). Metabolizes also benzaldehyde (PubMed:17382292). Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (PubMed:17382292, PubMed:23721920). May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor (PubMed:17382292). May have a protective role against the cytotoxicity induced by lipid peroxidation (PubMed:17382292). {ECO:0000269|PubMed:17382292, ECO:0000269|PubMed:23721920}.		alcohol metabolic process [GO:0006066]; aldehyde catabolic process [GO:0046185]; cellular aldehyde metabolic process [GO:0006081]; cellular response to oxidative stress [GO:0034599]; ethanol catabolic process [GO:0006068]; lipid metabolic process [GO:0006629]; response to oxidative stress [GO:0006979]; sphingolipid biosynthetic process [GO:0030148]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; vesicle [GO:0031982]	3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479]; benzaldehyde dehydrogenase (NADP+) activity [GO:0018477]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; vesicle [GO:0031982]; 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479]; benzaldehyde dehydrogenase (NADP+) activity [GO:0018477]; alcohol metabolic process [GO:0006066]; aldehyde catabolic process [GO:0046185]; cellular aldehyde metabolic process [GO:0006081]; cellular response to oxidative stress [GO:0034599]; ethanol catabolic process [GO:0006068]; lipid metabolic process [GO:0006629]; response to oxidative stress [GO:0006979]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23721920}; Lipid-anchor {ECO:0000269|PubMed:23721920}. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.
P43354	reviewed	NR4A2_HUMAN	Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor)	NR4A2 NOT NURR1 TINUR	Homo sapiens (Human)	598	FUNCTION: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed:17184956, PubMed:15716272). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250|UniProtKB:Q06219, ECO:0000269|PubMed:15716272, ECO:0000269|PubMed:17184956}.		adult locomotory behavior [GO:0008344]; canonical Wnt signaling pathway [GO:0060070]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; cellular response to extracellular stimulus [GO:0031668]; cellular response to oxidative stress [GO:0034599]; central nervous system neuron differentiation [GO:0021953]; central nervous system projection neuron axonogenesis [GO:0021952]; DNA-templated transcription [GO:0006351]; dopamine biosynthetic process [GO:0042416]; dopaminergic neuron differentiation [GO:0071542]; fat cell differentiation [GO:0045444]; general adaptation syndrome [GO:0051866]; habenula development [GO:0021986]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; neuron maturation [GO:0042551]; neuron migration [GO:0001764]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of dopamine metabolic process [GO:0042053]; regulation of respiratory gaseous exchange [GO:0043576]; regulation of transcription by RNA polymerase II [GO:0006357]; response to amphetamine [GO:0001975]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]	beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]; beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; adult locomotory behavior [GO:0008344]; canonical Wnt signaling pathway [GO:0060070]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; cellular response to extracellular stimulus [GO:0031668]; cellular response to oxidative stress [GO:0034599]; central nervous system neuron differentiation [GO:0021953]; central nervous system projection neuron axonogenesis [GO:0021952]; DNA-templated transcription [GO:0006351]; dopamine biosynthetic process [GO:0042416]; dopaminergic neuron differentiation [GO:0071542]; fat cell differentiation [GO:0045444]; general adaptation syndrome [GO:0051866]; habenula development [GO:0021986]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; neuron maturation [GO:0042551]; neuron migration [GO:0001764]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of dopamine metabolic process [GO:0042053]; regulation of respiratory gaseous exchange [GO:0043576]; regulation of transcription by RNA polymerase II [GO:0006357]; response to amphetamine [GO:0001975]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23283970}. Nucleus {ECO:0000269|PubMed:17184956, ECO:0000269|PubMed:23283970}. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization. {ECO:0000269|PubMed:23283970}.
P43355	reviewed	MAGA1_HUMAN	Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen)	MAGEA1 MAGE1 MAGE1A	Homo sapiens (Human)	309	FUNCTION: May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:15316101}.		negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	histone deacetylase binding [GO:0042826]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; histone deacetylase binding [GO:0042826]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
P43356	reviewed	MAGA2_HUMAN	Melanoma-associated antigen 2 (Cancer/testis antigen 1.2) (CT1.2) (MAGE-2 antigen)	MAGEA2 MAGE2 MAGEA2A; MAGEA2B MAGE2 MAGEA2	Homo sapiens (Human)	314	FUNCTION: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation. {ECO:0000269|PubMed:16847267, ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:22117195}.		cellular senescence [GO:0090398]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein catabolic process [GO:0030163]; signal transduction by p53 class mediator [GO:0072331]	nucleus [GO:0005634]; PML body [GO:0016605]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; ubiquitin protein ligase binding [GO:0031625]	nucleus [GO:0005634]; PML body [GO:0016605]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; ubiquitin protein ligase binding [GO:0031625]; cellular senescence [GO:0090398]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein catabolic process [GO:0030163]; signal transduction by p53 class mediator [GO:0072331]	SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body.
P43357	reviewed	MAGA3_HUMAN	Melanoma-associated antigen 3 (Antigen MZ2-D) (Cancer/testis antigen 1.3) (CT1.3) (MAGE-3 antigen)	MAGEA3 MAGE3	Homo sapiens (Human)	314	FUNCTION: Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy (PubMed:20864041, PubMed:31267705). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:17942928, PubMed:20864041). May play a role in embryonal development and tumor transformation or aspects of tumor progression (PubMed:17942928, PubMed:20864041). In vitro promotes cell viability in melanoma cell lines (PubMed:17942928). Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes (PubMed:8113684). {ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:31267705, ECO:0000269|PubMed:8113684}.		negative regulation of autophagy [GO:0010507]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of protein processing [GO:0010955]; negative regulation of transcription by RNA polymerase II [GO:0000122]	endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	caspase binding [GO:0089720]; histone deacetylase binding [GO:0042826]	endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; caspase binding [GO:0089720]; histone deacetylase binding [GO:0042826]; negative regulation of autophagy [GO:0010507]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of protein processing [GO:0010955]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
P43358	reviewed	MAGA4_HUMAN	Melanoma-associated antigen 4 (Cancer/testis antigen 1.4) (CT1.4) (MAGE-4 antigen) (MAGE-41 antigen) (MAGE-X2 antigen)	MAGEA4 MAGE4	Homo sapiens (Human)	317	FUNCTION: Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed:22842486). Also negatively regulates p53-mediated apoptosis (PubMed:22842486). {ECO:0000269|PubMed:22842486}.		negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle [GO:0045787]	nucleus [GO:0005634]	histone deacetylase binding [GO:0042826]	nucleus [GO:0005634]; histone deacetylase binding [GO:0042826]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle [GO:0045787]	
P43360	reviewed	MAGA6_HUMAN	Melanoma-associated antigen 6 (Cancer/testis antigen 1.6) (CT1.6) (MAGE-6 antigen) (MAGE3B antigen)	MAGEA6 MAGE6	Homo sapiens (Human)	314	FUNCTION: Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy (PubMed:31267705, PubMed:17942928, PubMed:20864041). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:17942928, PubMed:20864041). May play a role in tumor transformation or aspects of tumor progression (PubMed:17942928, PubMed:20864041). In vitro promotes cell viability in melanoma cell lines (PubMed:17942928). {ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:31267705}.		negative regulation of autophagy [GO:0010507]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	histone deacetylase binding [GO:0042826]	nucleus [GO:0005634]; histone deacetylase binding [GO:0042826]; negative regulation of autophagy [GO:0010507]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
P43361	reviewed	MAGA8_HUMAN	Melanoma-associated antigen 8 (Cancer/testis antigen 1.8) (CT1.8) (MAGE-8 antigen)	MAGEA8 MAGE8	Homo sapiens (Human)	318	FUNCTION: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	histone deacetylase binding [GO:0042826]	nucleus [GO:0005634]; histone deacetylase binding [GO:0042826]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
P43364	reviewed	MAGAB_HUMAN	Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen)	MAGEA11 MAGE11	Homo sapiens (Human)	429	FUNCTION: Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. {ECO:0000269|PubMed:15684378}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone deacetylase binding [GO:0042826]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone deacetylase binding [GO:0042826]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15684378}. Cytoplasm {ECO:0000269|PubMed:15684378}.
P43365	reviewed	MAGAC_HUMAN	Melanoma-associated antigen 12 (Cancer/testis antigen 1.12) (CT1.12) (MAGE-12 antigen) (MAGE12F antigen)	MAGEA12 MAGE12	Homo sapiens (Human)	314	FUNCTION: Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. {ECO:0000269|PubMed:17942928}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	histone deacetylase binding [GO:0042826]	nucleus [GO:0005634]; histone deacetylase binding [GO:0042826]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
P43378	reviewed	PTN9_HUMAN	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2)	PTPN9	Homo sapiens (Human)	593	FUNCTION: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus. {ECO:0000269|PubMed:19167335}.		negative regulation of neuron projection development [GO:0010977]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; neuron projection terminus [GO:0044306]; nucleoplasm [GO:0005654]	non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; neuron projection terminus [GO:0044306]; nucleoplasm [GO:0005654]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; negative regulation of neuron projection development [GO:0010977]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P43403	reviewed	ZAP70_HUMAN	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)	ZAP70 SRK	Homo sapiens (Human)	619	FUNCTION: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}.		adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; beta selection [GO:0043366]; calcium-mediated signaling [GO:0019722]; cell differentiation [GO:0030154]; immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative thymic T cell selection [GO:0045060]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of T cell differentiation [GO:0045582]; positive thymic T cell selection [GO:0045059]; protein phosphorylation [GO:0006468]; T cell activation [GO:0042110]; T cell aggregation [GO:0070489]; T cell differentiation [GO:0030217]; T cell migration [GO:0072678]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; beta selection [GO:0043366]; calcium-mediated signaling [GO:0019722]; cell differentiation [GO:0030154]; immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative thymic T cell selection [GO:0045060]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of T cell differentiation [GO:0045582]; positive thymic T cell selection [GO:0045059]; protein phosphorylation [GO:0006468]; T cell activation [GO:0042110]; T cell aggregation [GO:0070489]; T cell differentiation [GO:0030217]; T cell migration [GO:0072678]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9813084}. Cell membrane {ECO:0000269|PubMed:9813084}; Peripheral membrane protein {ECO:0000269|PubMed:9813084}. Note=In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity). {ECO:0000250}.
P43405	reviewed	KSYK_HUMAN	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)	SYK	Homo sapiens (Human)	635	FUNCTION: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:8657103, PubMed:34634301). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}.		adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; beta selection [GO:0043366]; blood vessel morphogenesis [GO:0048514]; calcium-mediated signaling [GO:0019722]; cell activation [GO:0001775]; cell differentiation [GO:0030154]; cellular response to lectin [GO:1990858]; cellular response to lipid [GO:0071396]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to molecule of fungal origin [GO:0071226]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; defense response to bacterium [GO:0042742]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; gamma-delta T cell differentiation [GO:0042492]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; interleukin-3-mediated signaling pathway [GO:0038156]; intracellular signal transduction [GO:0035556]; leukocyte activation involved in immune response [GO:0002366]; leukocyte cell-cell adhesion [GO:0007159]; leukotriene biosynthetic process [GO:0019370]; lymph vessel development [GO:0001945]; macrophage activation involved in immune response [GO:0002281]; mast cell degranulation [GO:0043303]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; neutrophil activation involved in immune response [GO:0002283]; neutrophil chemotaxis [GO:0030593]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-3 production [GO:0032752]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of killing of cells of another organism [GO:0051712]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor internalization [GO:0002092]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; receptor internalization [GO:0031623]; regulation of arachidonic acid secretion [GO:0090237]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of neutrophil degranulation [GO:0043313]; regulation of phagocytosis [GO:0050764]; regulation of platelet activation [GO:0010543]; regulation of platelet aggregation [GO:0090330]; regulation of superoxide anion generation [GO:0032928]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; serotonin secretion by platelet [GO:0002554]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	B cell receptor complex [GO:0019815]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early phagosome [GO:0032009]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; T cell receptor complex [GO:0042101]	ATP binding [GO:0005524]; integrin binding [GO:0005178]; interleukin-15 receptor binding [GO:0016170]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatase binding [GO:0019902]; phospholipase binding [GO:0043274]; phosphotyrosine residue binding [GO:0001784]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; Toll-like receptor binding [GO:0035325]	B cell receptor complex [GO:0019815]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early phagosome [GO:0032009]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; T cell receptor complex [GO:0042101]; ATP binding [GO:0005524]; integrin binding [GO:0005178]; interleukin-15 receptor binding [GO:0016170]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatase binding [GO:0019902]; phospholipase binding [GO:0043274]; phosphotyrosine residue binding [GO:0001784]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; Toll-like receptor binding [GO:0035325]; adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; beta selection [GO:0043366]; blood vessel morphogenesis [GO:0048514]; calcium-mediated signaling [GO:0019722]; cell activation [GO:0001775]; cell differentiation [GO:0030154]; cellular response to lectin [GO:1990858]; cellular response to lipid [GO:0071396]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to molecule of fungal origin [GO:0071226]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; defense response to bacterium [GO:0042742]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; gamma-delta T cell differentiation [GO:0042492]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; interleukin-3-mediated signaling pathway [GO:0038156]; intracellular signal transduction [GO:0035556]; leukocyte activation involved in immune response [GO:0002366]; leukocyte cell-cell adhesion [GO:0007159]; leukotriene biosynthetic process [GO:0019370]; lymph vessel development [GO:0001945]; macrophage activation involved in immune response [GO:0002281]; mast cell degranulation [GO:0043303]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; neutrophil activation involved in immune response [GO:0002283]; neutrophil chemotaxis [GO:0030593]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-3 production [GO:0032752]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of killing of cells of another organism [GO:0051712]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor internalization [GO:0002092]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; receptor internalization [GO:0031623]; regulation of arachidonic acid secretion [GO:0090237]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of neutrophil degranulation [GO:0043313]; regulation of phagocytosis [GO:0050764]; regulation of platelet activation [GO:0010543]; regulation of platelet aggregation [GO:0090330]; regulation of superoxide anion generation [GO:0032928]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; serotonin secretion by platelet [GO:0002554]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}. Cytoplasm, cytosol {ECO:0000305}.
P43487	reviewed	RANG_HUMAN	Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)	RANBP1	Homo sapiens (Human)	201	FUNCTION: Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7882974, PubMed:7616957). {ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957, ECO:0000269|PubMed:7882974}.		nucleocytoplasmic transport [GO:0006913]; positive regulation of mitotic centrosome separation [GO:0046604]; signal transduction [GO:0007165]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; nucleocytoplasmic transport [GO:0006913]; positive regulation of mitotic centrosome separation [GO:0046604]; signal transduction [GO:0007165]	
P43489	reviewed	TNR4_HUMAN	Tumor necrosis factor receptor superfamily member 4 (ACT35 antigen) (OX40L receptor) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD antigen CD134)	TNFRSF4 TXGP1L	Homo sapiens (Human)	277	FUNCTION: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. {ECO:0000269|PubMed:7704935}.; FUNCTION: (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B. {ECO:0000269|PubMed:23674671}.		immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of immunoglobulin production [GO:0002639]; T cell proliferation [GO:0042098]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	tumor necrosis factor receptor activity [GO:0005031]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; tumor necrosis factor receptor activity [GO:0005031]; virus receptor activity [GO:0001618]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of immunoglobulin production [GO:0002639]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P43490	reviewed	NAMPT_HUMAN	Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin)	NAMPT PBEF PBEF1	Homo sapiens (Human)	491	FUNCTION: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.		cell-cell signaling [GO:0007267]; circadian regulation of gene expression [GO:0032922]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; NAD biosynthetic process [GO:0009435]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]	cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]	cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; nicotinamide phosphoribosyltransferase activity [GO:0047280]	cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; nicotinamide phosphoribosyltransferase activity [GO:0047280]; cell-cell signaling [GO:0007267]; circadian regulation of gene expression [GO:0032922]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; NAD biosynthetic process [GO:0009435]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24130902}. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted {ECO:0000269|PubMed:21741723}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000269|PubMed:21741723, ECO:0000269|PubMed:24130902}.
P43626	reviewed	KI2L1_HUMAN	Killer cell immunoglobulin-like receptor 2DL1 (CD158 antigen-like family member A) (Natural killer-associated transcript 1) (NKAT-1) (p58 natural killer cell receptor clones CL-42/47.11) (p58 NK receptor CL-42/47.11) (p58.1 MHC class-I-specific NK receptor) (CD antigen CD158a)	KIR2DL1 CD158A NKAT1	Homo sapiens (Human)	348	FUNCTION: Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis. {ECO:0000269|PubMed:18604210}.		immune response [GO:0006955]; natural killer cell inhibitory signaling pathway [GO:0002769]	plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; immune response [GO:0006955]; natural killer cell inhibitory signaling pathway [GO:0002769]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18624290}; Single-pass type I membrane protein.
P43628	reviewed	KI2L3_HUMAN	Killer cell immunoglobulin-like receptor 2DL3 (CD158 antigen-like family member B2) (KIR-023GB) (Killer inhibitory receptor cl 2-3) (NKAT2a) (NKAT2b) (Natural killer-associated transcript 2) (NKAT-2) (p58 natural killer cell receptor clone CL-6) (p58 NK receptor CL-6) (p58.2 MHC class-I-specific NK receptor) (CD antigen CD158b2)	KIR2DL3 CD158B2 KIRCL23 NKAT2	Homo sapiens (Human)	341	FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.		immune response [GO:0006955]	membrane [GO:0016020]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]	membrane [GO:0016020]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P43629	reviewed	KI3L1_HUMAN	Killer cell immunoglobulin-like receptor 3DL1 (CD158 antigen-like family member E) (HLA-BW4-specific inhibitory NK cell receptor) (Natural killer-associated transcript 3) (NKAT-3) (p70 natural killer cell receptor clones CL-2/CL-11) (p70 NK receptor CL-2/CL-11) (CD antigen CD158e)	KIR3DL1 CD158E NKAT3 NKB1	Homo sapiens (Human)	444	FUNCTION: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. {ECO:0000269|PubMed:22020283}.		immune response [GO:0006955]; natural killer cell mediated cytotoxicity [GO:0042267]	plasma membrane [GO:0005886]	HLA-B specific inhibitory MHC class I receptor activity [GO:0030109]; molecular adaptor activity [GO:0060090]	plasma membrane [GO:0005886]; HLA-B specific inhibitory MHC class I receptor activity [GO:0030109]; molecular adaptor activity [GO:0060090]; immune response [GO:0006955]; natural killer cell mediated cytotoxicity [GO:0042267]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P43630	reviewed	KI3L2_HUMAN	Killer cell immunoglobulin-like receptor 3DL2 (CD158 antigen-like family member K) (Natural killer-associated transcript 4) (NKAT-4) (p70 natural killer cell receptor clone CL-5) (p70 NK receptor CL-5) (CD antigen CD158k)	KIR3DL2 CD158K NKAT4	Homo sapiens (Human)	455	FUNCTION: Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952). Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270). Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464). {ECO:0000269|PubMed:24018270, ECO:0000269|PubMed:26928464, ECO:0000269|PubMed:28636952}.		cellular defense response [GO:0006968]	plasma membrane [GO:0005886]	MHC class Ib protein binding [GO:0023029]	plasma membrane [GO:0005886]; MHC class Ib protein binding [GO:0023029]; cellular defense response [GO:0006968]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P43631	reviewed	KI2S2_HUMAN	Killer cell immunoglobulin-like receptor 2DS2 (CD158 antigen-like family member J) (NK receptor 183 ActI) (Natural killer-associated transcript 5) (NKAT-5) (p58 natural killer cell receptor clone CL-49) (p58 NK receptor CL-49) (CD antigen CD158j)	KIR2DS2 CD158J NKAT5	Homo sapiens (Human)	304	FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.		immune response [GO:0006955]; stimulatory killer cell immunoglobulin-like receptor signaling pathway [GO:0002222]	membrane [GO:0016020]; plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; immune response [GO:0006955]; stimulatory killer cell immunoglobulin-like receptor signaling pathway [GO:0002222]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P43632	reviewed	KI2S4_HUMAN	Killer cell immunoglobulin-like receptor 2DS4 (CD158 antigen-like family member I) (Natural killer-associated transcript 8) (NKAT-8) (P58 natural killer cell receptor clones CL-39/CL-17) (p58 NK receptor CL-39/CL-17) (CD antigen CD158i)	KIR2DS4 CD158I KKA3 NKAT8	Homo sapiens (Human)	304	FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. {ECO:0000269|PubMed:19858347}.			plasma membrane [GO:0005886]	MHC class Ib protein binding [GO:0023029]	plasma membrane [GO:0005886]; MHC class Ib protein binding [GO:0023029]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P43652	reviewed	AFAM_HUMAN	Afamin (Alpha-albumin) (Alpha-Alb)	AFM ALB2 ALBA	Homo sapiens (Human)	599	FUNCTION: Functions as carrier for hydrophobic molecules in body fluids (Probable). Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B (PubMed:26902720). Binds vitamin E (PubMed:15952736, PubMed:12463752). May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient (PubMed:15952736). May be involved in the transport of vitamin E across the blood-brain barrier (PubMed:19046407). {ECO:0000269|PubMed:12463752, ECO:0000269|PubMed:15952736, ECO:0000269|PubMed:19046407, ECO:0000269|PubMed:26902720, ECO:0000305}.		protein stabilization [GO:0050821]; protein transport within extracellular region [GO:0071693]; vitamin transport [GO:0051180]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	vitamin E binding [GO:0008431]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; vitamin E binding [GO:0008431]; protein stabilization [GO:0050821]; protein transport within extracellular region [GO:0071693]; vitamin transport [GO:0051180]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12463752, ECO:0000269|PubMed:15952736, ECO:0000269|PubMed:26902720, ECO:0000269|PubMed:7517938}.
P43657	reviewed	LPAR6_HUMAN	Lysophosphatidic acid receptor 6 (LPA receptor 6) (LPA-6) (Oleoyl-L-alpha-lysophosphatidic acid receptor) (P2Y purinoceptor 5) (P2Y5) (Purinergic receptor 5) (RB intron encoded G-protein coupled receptor)	LPAR6 P2RY5	Homo sapiens (Human)	344	FUNCTION: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. {ECO:0000269|PubMed:18297070}.	MISCELLANEOUS: This is a nested gene within intron 17 of the retinoblastoma gene.	blastocyst hatching [GO:0001835]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	plasma membrane [GO:0005886]	lysophosphatidic acid receptor activity [GO:0070915]	plasma membrane [GO:0005886]; lysophosphatidic acid receptor activity [GO:0070915]; blastocyst hatching [GO:0001835]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18297070, ECO:0000269|PubMed:36173926}; Multi-pass membrane protein {ECO:0000269|PubMed:18297070}.
P43681	reviewed	ACHA4_HUMAN	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4 NACRA4	Homo sapiens (Human)	627	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. {ECO:0000269|PubMed:22361591}.		action potential [GO:0001508]; B cell activation [GO:0042113]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; DNA repair [GO:0006281]; inhibitory postsynaptic potential [GO:0060080]; membrane depolarization [GO:0051899]; monoatomic ion transport [GO:0006811]; nervous system process [GO:0050877]; regulation of dopamine secretion [GO:0014059]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; response to oxidative stress [GO:0006979]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]	acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]; action potential [GO:0001508]; B cell activation [GO:0042113]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; DNA repair [GO:0006281]; inhibitory postsynaptic potential [GO:0060080]; membrane depolarization [GO:0051899]; monoatomic ion transport [GO:0006811]; nervous system process [GO:0050877]; regulation of dopamine secretion [GO:0014059]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; response to oxidative stress [GO:0006979]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
P43686	reviewed	PRS6B_HUMAN	26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)	PSMC4 MIP224 TBP7	Homo sapiens (Human)	418	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:8060531}.		blastocyst development [GO:0001824]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis [GO:0006508]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]; blastocyst development [GO:0001824]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
P43694	reviewed	GATA4_HUMAN	Transcription factor GATA-4 (GATA-binding factor 4)	GATA4	Homo sapiens (Human)	442	FUNCTION: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724, PubMed:35182466). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735). {ECO:0000250|UniProtKB:P46152, ECO:0000250|UniProtKB:Q08369, ECO:0000269|PubMed:15734735, ECO:0000269|PubMed:20081228, ECO:0000269|PubMed:21220346, ECO:0000269|PubMed:24000169, ECO:0000269|PubMed:27984724, ECO:0000269|PubMed:35182466}.		aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; atrial septum primum morphogenesis [GO:0003289]; atrial septum secundum morphogenesis [GO:0003290]; atrioventricular canal development [GO:0036302]; atrioventricular node development [GO:0003162]; atrioventricular valve formation [GO:0003190]; cardiac muscle tissue regeneration [GO:0061026]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac ventricle morphogenesis [GO:0003208]; cell fate commitment [GO:0045165]; cell growth involved in cardiac muscle cell development [GO:0061049]; cell-cell signaling [GO:0007267]; cellular response to glucose stimulus [GO:0071333]; embryonic foregut morphogenesis [GO:0048617]; embryonic heart tube anterior/posterior pattern specification [GO:0035054]; endocardial cushion development [GO:0003197]; endoderm development [GO:0007492]; heart looping [GO:0001947]; intestinal epithelial cell differentiation [GO:0060575]; male gonad development [GO:0008584]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of autophagy [GO:0010507]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of DNA-templated transcription [GO:0006355]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; response to mechanical stimulus [GO:0009612]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; transdifferentiation [GO:0060290]; ventricular septum development [GO:0003281]; wound healing [GO:0042060]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; NFAT protein binding [GO:0051525]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; NFAT protein binding [GO:0051525]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; atrial septum primum morphogenesis [GO:0003289]; atrial septum secundum morphogenesis [GO:0003290]; atrioventricular canal development [GO:0036302]; atrioventricular node development [GO:0003162]; atrioventricular valve formation [GO:0003190]; cardiac muscle tissue regeneration [GO:0061026]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac ventricle morphogenesis [GO:0003208]; cell fate commitment [GO:0045165]; cell growth involved in cardiac muscle cell development [GO:0061049]; cell-cell signaling [GO:0007267]; cellular response to glucose stimulus [GO:0071333]; embryonic foregut morphogenesis [GO:0048617]; embryonic heart tube anterior/posterior pattern specification [GO:0035054]; endocardial cushion development [GO:0003197]; endoderm development [GO:0007492]; heart looping [GO:0001947]; intestinal epithelial cell differentiation [GO:0060575]; male gonad development [GO:0008584]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of autophagy [GO:0010507]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of DNA-templated transcription [GO:0006355]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; response to mechanical stimulus [GO:0009612]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; transdifferentiation [GO:0060290]; ventricular septum development [GO:0003281]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21220346, ECO:0000269|PubMed:24000169}.
P43699	reviewed	NKX21_HUMAN	Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP)	NKX2-1 NKX2A TITF1 TTF1	Homo sapiens (Human)	371	FUNCTION: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). {ECO:0000250|UniProtKB:P23441, ECO:0000250|UniProtKB:P50220}.		anatomical structure formation involved in morphogenesis [GO:0048646]; axon guidance [GO:0007411]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cerebral cortex cell migration [GO:0021795]; cerebral cortex GABAergic interneuron differentiation [GO:0021892]; club cell differentiation [GO:0060486]; developmental induction [GO:0031128]; endoderm development [GO:0007492]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; forebrain development [GO:0030900]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain neuron fate commitment [GO:0021877]; gene expression [GO:0010467]; globus pallidus development [GO:0021759]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; interneuron migration [GO:1904936]; Leydig cell differentiation [GO:0033327]; locomotory behavior [GO:0007626]; lung development [GO:0030324]; lung saccule development [GO:0060430]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; oligodendrocyte differentiation [GO:0048709]; phospholipid metabolic process [GO:0006644]; pituitary gland development [GO:0021983]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hormone [GO:0009725]; rhythmic process [GO:0048511]; thyroid gland development [GO:0030878]; type II pneumocyte differentiation [GO:0060510]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure formation involved in morphogenesis [GO:0048646]; axon guidance [GO:0007411]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cerebral cortex cell migration [GO:0021795]; cerebral cortex GABAergic interneuron differentiation [GO:0021892]; club cell differentiation [GO:0060486]; developmental induction [GO:0031128]; endoderm development [GO:0007492]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; forebrain development [GO:0030900]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain neuron fate commitment [GO:0021877]; gene expression [GO:0010467]; globus pallidus development [GO:0021759]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; interneuron migration [GO:1904936]; Leydig cell differentiation [GO:0033327]; locomotory behavior [GO:0007626]; lung development [GO:0030324]; lung saccule development [GO:0060430]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; oligodendrocyte differentiation [GO:0048709]; phospholipid metabolic process [GO:0006644]; pituitary gland development [GO:0021983]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hormone [GO:0009725]; rhythmic process [GO:0048511]; thyroid gland development [GO:0030878]; type II pneumocyte differentiation [GO:0060510]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P50220}.
P43897	reviewed	EFTS_HUMAN	Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt)	TSFM	Homo sapiens (Human)	325	FUNCTION: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. {ECO:0000255|HAMAP-Rule:MF_03135, ECO:0000269|PubMed:27677415}.		mitochondrial translational elongation [GO:0070125]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of mitochondrial translation [GO:0070129]; translational elongation [GO:0006414]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; mitochondrial translational elongation [GO:0070125]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of mitochondrial translation [GO:0070129]; translational elongation [GO:0006414]	SUBCELLULAR LOCATION: Mitochondrion.
P45378	reviewed	TNNT3_HUMAN	Troponin T, fast skeletal muscle (TnTf) (Beta-TnTF) (Fast skeletal muscle troponin T) (fTnT)	TNNT3	Homo sapiens (Human)	269	FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	MISCELLANEOUS: [Isoform 5]: Minor isoform detected in approximately 1% of cDNA clones. {ECO:0000305}.	positive regulation of calcium-dependent ATPase activity [GO:1903612]; regulation of ATP-dependent activity [GO:0043462]; regulation of striated muscle contraction [GO:0006942]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]	cytosol [GO:0005829]; troponin complex [GO:0005861]	calcium-dependent protein binding [GO:0048306]; tropomyosin binding [GO:0005523]; troponin C binding [GO:0030172]; troponin I binding [GO:0031013]	cytosol [GO:0005829]; troponin complex [GO:0005861]; calcium-dependent protein binding [GO:0048306]; tropomyosin binding [GO:0005523]; troponin C binding [GO:0030172]; troponin I binding [GO:0031013]; positive regulation of calcium-dependent ATPase activity [GO:1903612]; regulation of ATP-dependent activity [GO:0043462]; regulation of striated muscle contraction [GO:0006942]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]	
P45379	reviewed	TNNT2_HUMAN	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)	TNNT2	Homo sapiens (Human)	298	FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.		cardiac muscle contraction [GO:0060048]; muscle filament sliding [GO:0030049]; negative regulation of ATP-dependent activity [GO:0032780]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of heart contraction [GO:0008016]; regulation of muscle contraction [GO:0006937]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	cardiac myofibril [GO:0097512]; cardiac Troponin complex [GO:1990584]; cytosol [GO:0005829]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]; troponin complex [GO:0005861]	actin binding [GO:0003779]; identical protein binding [GO:0042802]; tropomyosin binding [GO:0005523]; troponin C binding [GO:0030172]; troponin I binding [GO:0031013]	cardiac myofibril [GO:0097512]; cardiac Troponin complex [GO:1990584]; cytosol [GO:0005829]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]; troponin complex [GO:0005861]; actin binding [GO:0003779]; identical protein binding [GO:0042802]; tropomyosin binding [GO:0005523]; troponin C binding [GO:0030172]; troponin I binding [GO:0031013]; cardiac muscle contraction [GO:0060048]; muscle filament sliding [GO:0030049]; negative regulation of ATP-dependent activity [GO:0032780]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of heart contraction [GO:0008016]; regulation of muscle contraction [GO:0006937]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	
P45381	reviewed	ACY2_HUMAN	Aspartoacylase (EC 3.5.1.15) (Aminoacylase-2) (ACY-2)	ASPA ACY2 ASP	Homo sapiens (Human)	313	FUNCTION: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids.		acetate metabolic process [GO:0006083]; aspartate catabolic process [GO:0006533]; central nervous system myelination [GO:0022010]; positive regulation of oligodendrocyte differentiation [GO:0048714]	cytosol [GO:0005829]; nucleus [GO:0005634]	aminoacylase activity [GO:0004046]; aspartoacylase activity [GO:0019807]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; nucleus [GO:0005634]; aminoacylase activity [GO:0004046]; aspartoacylase activity [GO:0019807]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; acetate metabolic process [GO:0006083]; aspartate catabolic process [GO:0006533]; central nervous system myelination [GO:0022010]; positive regulation of oligodendrocyte differentiation [GO:0048714]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
P45452	reviewed	MMP13_HUMAN	Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13)	MMP13	Homo sapiens (Human)	471	FUNCTION: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. {ECO:0000269|PubMed:16167086, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:19615667, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:8207000, ECO:0000269|PubMed:8576151, ECO:0000269|PubMed:8603731, ECO:0000269|PubMed:8663255, ECO:0000269|PubMed:9065415}.		bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; collagen catabolic process [GO:0030574]; endochondral ossification [GO:0001958]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; growth plate cartilage development [GO:0003417]; proteolysis [GO:0006508]; response to amyloid-beta [GO:1904645]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; collagen catabolic process [GO:0030574]; endochondral ossification [GO:0001958]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; growth plate cartilage development [GO:0003417]; proteolysis [GO:0006508]; response to amyloid-beta [GO:1904645]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:8576151}. Secreted {ECO:0000269|PubMed:8576151}.
P45844	reviewed	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1 (EC 7.6.2.-) (ATP-binding cassette transporter 8) (White protein homolog)	ABCG1 ABC8 WHT1	Homo sapiens (Human)	678	FUNCTION: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620). {ECO:0000269|PubMed:16702602, ECO:0000269|PubMed:17408620, ECO:0000269|PubMed:24576892}.		amyloid precursor protein catabolic process [GO:0042987]; cellular response to high density lipoprotein particle stimulus [GO:0071403]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; glycoprotein transport [GO:0034436]; high-density lipoprotein particle remodeling [GO:0034375]; intracellular cholesterol transport [GO:0032367]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of protein secretion [GO:0050714]; regulation of cholesterol metabolic process [GO:0090181]; response to lipid [GO:0033993]; response to organic substance [GO:0010033]; reverse cholesterol transport [GO:0043691]; transmembrane transport [GO:0055085]	endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	ABC-type sterol transporter activity [GO:0034041]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phospholipid binding [GO:0005543]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; toxin transmembrane transporter activity [GO:0019534]	endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; ABC-type sterol transporter activity [GO:0034041]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phospholipid binding [GO:0005543]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; toxin transmembrane transporter activity [GO:0019534]; amyloid precursor protein catabolic process [GO:0042987]; cellular response to high density lipoprotein particle stimulus [GO:0071403]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; glycoprotein transport [GO:0034436]; high-density lipoprotein particle remodeling [GO:0034375]; intracellular cholesterol transport [GO:0032367]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of protein secretion [GO:0050714]; regulation of cholesterol metabolic process [GO:0090181]; response to lipid [GO:0033993]; response to organic substance [GO:0010033]; reverse cholesterol transport [GO:0043691]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22042635}; Multi-pass membrane protein {ECO:0000269|PubMed:22042635}. Golgi apparatus membrane {ECO:0000269|PubMed:22042635}; Multi-pass membrane protein {ECO:0000269|PubMed:22042635}. Cell membrane {ECO:0000269|PubMed:16702602, ECO:0000269|PubMed:24576892}. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.
P45877	reviewed	PPIC_HUMAN	Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C)	PPIC CYPC	Homo sapiens (Human)	212	FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269|PubMed:20676357}.		protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P30412}.
P45880	reviewed	VDAC2_HUMAN	Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)	VDAC2	Homo sapiens (Human)	294	FUNCTION: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432). {ECO:0000250|UniProtKB:P21796, ECO:0000269|PubMed:31015432}.		binding of sperm to zona pellucida [GO:0007339]; mitochondrial outer membrane permeabilization [GO:0097345]; monoatomic anion transport [GO:0006820]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of protein polymerization [GO:0032272]	acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pore complex [GO:0046930]; sperm midpiece [GO:0097225]	ceramide binding [GO:0097001]; cholesterol binding [GO:0015485]; nucleotide binding [GO:0000166]; phosphatidylcholine binding [GO:0031210]; porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308]	acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pore complex [GO:0046930]; sperm midpiece [GO:0097225]; ceramide binding [GO:0097001]; cholesterol binding [GO:0015485]; nucleotide binding [GO:0000166]; phosphatidylcholine binding [GO:0031210]; porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308]; binding of sperm to zona pellucida [GO:0007339]; mitochondrial outer membrane permeabilization [GO:0097345]; monoatomic anion transport [GO:0006820]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of protein polymerization [GO:0032272]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:7539795}. Membrane {ECO:0000269|PubMed:27641616}. Note=May localize to non-mitochondrial membranes. {ECO:0000269|PubMed:27641616}.
P45954	reviewed	ACDSB_HUMAN	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)	ACADSB	Homo sapiens (Human)	432	FUNCTION: Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:7698750, PubMed:11013134, PubMed:21430231, PubMed:10832746). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (PubMed:7698750, PubMed:11013134, PubMed:21430231, PubMed:10832746). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway (PubMed:11013134, PubMed:10832746). Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug (PubMed:8660691). {ECO:0000269|PubMed:10832746, ECO:0000269|PubMed:11013134, ECO:0000269|PubMed:21430231, ECO:0000269|PubMed:7698750, ECO:0000269|PubMed:8660691}.		fatty acid metabolic process [GO:0006631]; isoleucine catabolic process [GO:0006550]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	2-methylacyl-CoA dehydrogenase activity [GO:0003853]; acyl-CoA dehydrogenase activity [GO:0003995]; butyryl-CoA dehydrogenase activity [GO:0004085]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; isobutyryl-CoA:FAD oxidoreductase activity [GO:0102035]; short-chain-acyl-CoA dehydrogenase activity [GO:0016937]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 2-methylacyl-CoA dehydrogenase activity [GO:0003853]; acyl-CoA dehydrogenase activity [GO:0003995]; butyryl-CoA dehydrogenase activity [GO:0004085]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; isobutyryl-CoA:FAD oxidoreductase activity [GO:0102035]; short-chain-acyl-CoA dehydrogenase activity [GO:0016937]; fatty acid metabolic process [GO:0006631]; isoleucine catabolic process [GO:0006550]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:11013134}.
P45973	reviewed	CBX5_HUMAN	Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)	CBX5 HP1A	Homo sapiens (Human)	191	FUNCTION: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. {ECO:0000269|PubMed:19783980}.		chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]	chromocenter [GO:0010369]; chromosome, telomeric region [GO:0000781]; heterochromatin [GO:0000792]; histone deacetylase complex [GO:0000118]; histone methyltransferase complex [GO:0035097]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; site of DNA damage [GO:0090734]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; ribonucleoprotein complex binding [GO:0043021]	chromocenter [GO:0010369]; chromosome, telomeric region [GO:0000781]; heterochromatin [GO:0000792]; histone deacetylase complex [GO:0000118]; histone methyltransferase complex [GO:0035097]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; site of DNA damage [GO:0090734]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; ribonucleoprotein complex binding [GO:0043021]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:28977666}. Chromosome {ECO:0000269|PubMed:10460410}. Chromosome, centromere {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:21346195}. Note=Colocalizes with HNRNPU in the nucleus (PubMed:19617346). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase (PubMed:19617346). Localizes to sites of DNA damage (PubMed:28977666). {ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:28977666}.
P45974	reviewed	UBP5_HUMAN	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)	USP5 ISOT	Homo sapiens (Human)	858	FUNCTION: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. {ECO:0000269|PubMed:19098288}.	MISCELLANEOUS: The UBP-type zinc finger domain crystallizes as a dimer linked by a disulfide bond between the Cys-195 residues of both molecules, but there is no evidence that the full-length USP5 exists as a dimer.	positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; lysosome [GO:0005764]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; lysosome [GO:0005764]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567]	
P45983	reviewed	MK08_HUMAN	Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)	MAPK8 JNK1 PRKM8 SAPK1 SAPK1C	Homo sapiens (Human)	427	FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway (PubMed:28943315). In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity (PubMed:18307971). Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins (PubMed:21856198). Loss of this interaction abrogates the acetylation required for replication initiation (PubMed:21856198). Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1 (PubMed:21364637). In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation (PubMed:21095239). Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy (PubMed:18570871). Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons (By similarity). In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone (By similarity). Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH (PubMed:20027304, PubMed:16581800, PubMed:17296730). Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly (PubMed:22966201). Phosphorylates SIRT6 in response to oxidative stress, stimulating its mono-ADP-ribosyltransferase activity (PubMed:27568560). Phosphorylates NLRP3, promoting assembly of the NLRP3 inflammasome (PubMed:28943315). {ECO:0000250|UniProtKB:P49185, ECO:0000250|UniProtKB:Q91Y86, ECO:0000269|PubMed:10747973, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:18307971, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20027304, ECO:0000269|PubMed:21095239, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:28943315}.; FUNCTION: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.		cellular response to amino acid starvation [GO:0034198]; cellular response to cadmium ion [GO:0071276]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; JUN phosphorylation [GO:0007258]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein binding [GO:0032091]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell killing [GO:0031343]; positive regulation of cyclase activity [GO:0031281]; positive regulation of gene expression [GO:0010628]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; positive regulation of protein metabolic process [GO:0051247]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of DNA replication origin binding [GO:1902595]; regulation of macroautophagy [GO:0016241]; regulation of protein localization [GO:0032880]; response to mechanical stimulus [GO:0009612]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; stress-activated MAPK cascade [GO:0051403]	axon [GO:0030424]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; histone deacetylase regulator activity [GO:0035033]; JUN kinase activity [GO:0004705]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase binding [GO:0120283]	axon [GO:0030424]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; histone deacetylase regulator activity [GO:0035033]; JUN kinase activity [GO:0004705]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase binding [GO:0120283]; cellular response to amino acid starvation [GO:0034198]; cellular response to cadmium ion [GO:0071276]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; JUN phosphorylation [GO:0007258]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein binding [GO:0032091]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell killing [GO:0031343]; positive regulation of cyclase activity [GO:0031281]; positive regulation of gene expression [GO:0010628]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; positive regulation of protein metabolic process [GO:0051247]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of DNA replication origin binding [GO:1902595]; regulation of macroautophagy [GO:0016241]; regulation of protein localization [GO:0032880]; response to mechanical stimulus [GO:0009612]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; stress-activated MAPK cascade [GO:0051403]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21148294}. Nucleus {ECO:0000269|PubMed:21148294, ECO:0000269|PubMed:30878395}. Synapse {ECO:0000250|UniProtKB:P49185}. Note=In the cortical neurons, predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity). Colocalizes with POU5F1 in the nucleus. {ECO:0000250|UniProtKB:P49185, ECO:0000250|UniProtKB:Q91Y86}.
P45984	reviewed	MK09_HUMAN	Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)	MAPK9 JNK2 PRKM9 SAPK1A	Homo sapiens (Human)	424	FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:Q9WTU6, ECO:0000269|PubMed:22441692}.; FUNCTION: MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.		apoptotic signaling pathway [GO:0097190]; cellular response to cadmium ion [GO:0071276]; cellular response to reactive oxygen species [GO:0034614]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; inflammatory response to wounding [GO:0090594]; JNK cascade [GO:0007254]; modulation of chemical synaptic transmission [GO:0050804]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of podosome assembly [GO:0071803]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein localization to tricellular tight junction [GO:0061833]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]	ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; protein serine kinase activity [GO:0106310]; protein serine/threonine/tyrosine kinase activity [GO:0004712]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; protein serine kinase activity [GO:0106310]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; apoptotic signaling pathway [GO:0097190]; cellular response to cadmium ion [GO:0071276]; cellular response to reactive oxygen species [GO:0034614]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; inflammatory response to wounding [GO:0090594]; JNK cascade [GO:0007254]; modulation of chemical synaptic transmission [GO:0050804]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of podosome assembly [GO:0071803]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein localization to tricellular tight junction [GO:0061833]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19675674}. Nucleus {ECO:0000269|PubMed:19675674}. Note=Colocalizes with POU5F1 in the nucleus. {ECO:0000250|UniProtKB:Q9WTU6}.
P45985	reviewed	MP2K4_HUMAN	Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK)	MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1	Homo sapiens (Human)	399	FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}.		cell growth involved in cardiac muscle cell development [GO:0061049]; cellular response to mechanical stimulus [GO:0071260]; cellular response to sorbitol [GO:0072709]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of motor neuron apoptotic process [GO:2000672]; phosphorylation [GO:0016310]; positive regulation of DNA replication [GO:0045740]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of protein phosphorylation [GO:0001934]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; smooth muscle cell apoptotic process [GO:0034390]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; nucleus [GO:0005634]; perikaryon [GO:0043204]	ATP binding [GO:0005524]; JUN kinase kinase activity [GO:0008545]; molecular adaptor activity [GO:0060090]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; nucleus [GO:0005634]; perikaryon [GO:0043204]; ATP binding [GO:0005524]; JUN kinase kinase activity [GO:0008545]; molecular adaptor activity [GO:0060090]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; cell growth involved in cardiac muscle cell development [GO:0061049]; cellular response to mechanical stimulus [GO:0071260]; cellular response to sorbitol [GO:0072709]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of motor neuron apoptotic process [GO:2000672]; phosphorylation [GO:0016310]; positive regulation of DNA replication [GO:0045740]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of protein phosphorylation [GO:0001934]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; smooth muscle cell apoptotic process [GO:0034390]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
P46013	reviewed	KI67_HUMAN	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	MKI67	Homo sapiens (Human)	3256	FUNCTION: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226}.		cell cycle [GO:0007049]; cell population proliferation [GO:0008283]; regulation of chromatin organization [GO:1902275]; regulation of chromosome segregation [GO:0051983]; regulation of mitotic nuclear division [GO:0007088]	chromosome [GO:0005694]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; RNA binding [GO:0003723]	chromosome [GO:0005694]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; cell cycle [GO:0007049]; cell population proliferation [GO:0008283]; regulation of chromatin organization [GO:1902275]; regulation of chromosome segregation [GO:0051983]; regulation of mitotic nuclear division [GO:0007088]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:15896774, ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:9510506}. Nucleus {ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:22002106}. Nucleus, nucleolus {ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:2674163, ECO:0000269|PubMed:8799815}. Note=Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106). {ECO:0000269|PubMed:15896774, ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:27362226}.
P46019	reviewed	KPB2_HUMAN	Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit)	PHKA2 PHKLA PYK	Homo sapiens (Human)	1235	FUNCTION: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.		carbohydrate metabolic process [GO:0005975]; generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; protein modification process [GO:0036211]	cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689]	cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689]; carbohydrate metabolic process [GO:0005975]; generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P46020	reviewed	KPB1_HUMAN	Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit)	PHKA1 PHKA	Homo sapiens (Human)	1223	FUNCTION: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.		generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]	cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689]	cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689]; generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P46059	reviewed	S15A1_HUMAN	Solute carrier family 15 member 1 (Intestinal H(+)/peptide cotransporter) (Oligopeptide transporter, small intestine isoform) (Peptide transporter 1)	SLC15A1 PEPT1	Homo sapiens (Human)	708	FUNCTION: Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (PubMed:7896779, PubMed:9835627, PubMed:8914574, PubMed:15521010, PubMed:18367661, PubMed:19685173, PubMed:26320580) (By similarity). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system (PubMed:9835627, PubMed:15521010). {ECO:0000250|UniProtKB:P36836, ECO:0000269|PubMed:15521010, ECO:0000269|PubMed:18367661, ECO:0000269|PubMed:19685173, ECO:0000269|PubMed:7896779, ECO:0000269|PubMed:8914574, ECO:0000269|PubMed:9835627}.		dipeptide import across plasma membrane [GO:0140206]; monoatomic ion transport [GO:0006811]; protein transport [GO:0015031]; tripeptide import across plasma membrane [GO:0140207]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; membrane [GO:0016020]; plasma membrane [GO:0005886]	dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; proton-dependent oligopeptide secondary active transmembrane transporter activity [GO:0005427]; tripeptide transmembrane transporter activity [GO:0042937]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; membrane [GO:0016020]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; proton-dependent oligopeptide secondary active transmembrane transporter activity [GO:0005427]; tripeptide transmembrane transporter activity [GO:0042937]; dipeptide import across plasma membrane [GO:0140206]; monoatomic ion transport [GO:0006811]; protein transport [GO:0015031]; tripeptide import across plasma membrane [GO:0140207]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:28408210}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the apical membrane of enterocytes. {ECO:0000269|PubMed:28408210}.
P46060	reviewed	RAGP1_HUMAN	Ran GTPase-activating protein 1 (RanGAP1)	RANGAP1 KIAA1835 SD	Homo sapiens (Human)	587	FUNCTION: GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}.		activation of GTPase activity [GO:0090630]; cellular response to vasopressin [GO:1904117]; negative regulation of protein export from nucleus [GO:0046826]; nuclear export [GO:0051168]; nucleocytoplasmic transport [GO:0006913]; protein sumoylation [GO:0016925]; response to axon injury [GO:0048678]; signal transduction [GO:0007165]	aggresome [GO:0016235]; axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SUMO ligase complex [GO:0106068]	cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625]	aggresome [GO:0016235]; axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SUMO ligase complex [GO:0106068]; cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625]; activation of GTPase activity [GO:0090630]; cellular response to vasopressin [GO:1904117]; negative regulation of protein export from nucleus [GO:0046826]; nuclear export [GO:0051168]; nucleocytoplasmic transport [GO:0006913]; protein sumoylation [GO:0016925]; response to axon injury [GO:0048678]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15037602, ECO:0000305|PubMed:8146159}. Nucleus, nucleoplasm {ECO:0000269|PubMed:8146159}. Nucleus envelope {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11854305}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}. Note=Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requires sumoylation (PubMed:11854305). {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}.
P46063	reviewed	RECQ1_HUMAN	ATP-dependent DNA helicase Q1 (EC 3.6.4.12) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1)	RECQL RECQ1 RECQL1	Homo sapiens (Human)	649	FUNCTION: DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. {ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:7527136, ECO:0000269|PubMed:7961977, ECO:0000269|PubMed:8056767}.		DNA repair [GO:0006281]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; DNA repair [GO:0006281]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7961977}.
P46087	reviewed	NOP2_HUMAN	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120)	NOP2 NOL1 NSUN1	Homo sapiens (Human)	812	FUNCTION: Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable). {ECO:0000269|PubMed:24120868, ECO:0000305, ECO:0000305|PubMed:23913415}.		maturation of LSU-rRNA [GO:0000470]; positive regulation of cell population proliferation [GO:0008284]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; rRNA base methylation [GO:0070475]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383]; maturation of LSU-rRNA [GO:0000470]; positive regulation of cell population proliferation [GO:0008284]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; rRNA base methylation [GO:0070475]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
P46089	reviewed	GPR3_HUMAN	G-protein coupled receptor 3 (ACCA orphan receptor)	GPR3 ACCA	Homo sapiens (Human)	330	FUNCTION: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:19213921}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of meiotic nuclear division [GO:0040020]; regulation of metabolic process [GO:0019222]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of meiotic nuclear division [GO:0040020]; regulation of metabolic process [GO:0019222]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P46091	reviewed	CML2_HUMAN	Chemerin-like receptor 2 (Chemerin chemokine-like receptor 2) (Chemokine-like receptor 2) (G-protein coupled receptor 1)	CMKLR2 GPR1	Homo sapiens (Human)	355	FUNCTION: Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822). Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q8K087, ECO:0000269|PubMed:18165312, ECO:0000269|PubMed:27716822}.; FUNCTION: (Microbial infection) Coreceptor for HIV-1. {ECO:0000269|PubMed:10233994}.		G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; neuropeptide signaling pathway [GO:0007218]	intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	adipokinetic hormone binding [GO:0097004]; adipokinetic hormone receptor activity [GO:0097003]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]	intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; adipokinetic hormone binding [GO:0097004]; adipokinetic hormone receptor activity [GO:0097003]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27716822}; Multi-pass membrane protein {ECO:0000255}. Note=Internalizes in presence of its ligand, TAFA1 (By similarity). Internalizes efficiently in response to RARRES2 (PubMed:27716822). {ECO:0000250|UniProtKB:Q8K087, ECO:0000269|PubMed:27716822}.
P46092	reviewed	CCR10_HUMAN	C-C chemokine receptor type 10 (C-C CKR-10) (CC-CKR-10) (CCR-10) (G-protein coupled receptor 2)	CCR10 GPR2	Homo sapiens (Human)	362	FUNCTION: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.		calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; G protein-coupled receptor activity [GO:0004930]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; G protein-coupled receptor activity [GO:0004930]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P46093	reviewed	GPR4_HUMAN	G-protein coupled receptor 4 (G-protein coupled receptor 6C.l) (GPR6C.l)	GPR4	Homo sapiens (Human)	362	FUNCTION: Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways (PubMed:12955148, PubMed:17462861, PubMed:22110680, PubMed:20211729). Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway (PubMed:32058960). In the brain may mediate central respiratory sensitivity to CO(2)H(+) (By similarity). {ECO:0000250|UniProtKB:Q8BUD0, ECO:0000269|PubMed:12955148, ECO:0000269|PubMed:17462861, ECO:0000269|PubMed:20211729, ECO:0000269|PubMed:22110680, ECO:0000269|PubMed:32058960}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis involved in wound healing [GO:0060055]; G protein-coupled receptor signaling pathway [GO:0007186]; glomerular mesangial cell development [GO:0072144]; negative regulation of angiogenesis [GO:0016525]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of inflammatory response [GO:0050729]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell adhesion [GO:0030155]; regulation of vascular permeability [GO:0043114]; response to acidic pH [GO:0010447]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis involved in wound healing [GO:0060055]; G protein-coupled receptor signaling pathway [GO:0007186]; glomerular mesangial cell development [GO:0072144]; negative regulation of angiogenesis [GO:0016525]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of inflammatory response [GO:0050729]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell adhesion [GO:0030155]; regulation of vascular permeability [GO:0043114]; response to acidic pH [GO:0010447]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17462861, ECO:0000269|PubMed:20211729}; Multi-pass membrane protein {ECO:0000255}.
P46094	reviewed	XCR1_HUMAN	Chemokine XC receptor 1 (G-protein coupled receptor 5) (Lymphotactin receptor) (XC chemokine receptor 1)	XCR1 CCXCR1 GPR5	Homo sapiens (Human)	333	FUNCTION: Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin. {ECO:0000305}.		calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; release of sequestered calcium ion into cytosol [GO:0051209]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; release of sequestered calcium ion into cytosol [GO:0051209]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P46098	reviewed	5HT3A_HUMAN	5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor)	HTR3A 5HT3R HTR3	Homo sapiens (Human)	478	FUNCTION: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. {ECO:0000269|PubMed:10521471, ECO:0000269|PubMed:12867984, ECO:0000269|PubMed:17392525, ECO:0000269|PubMed:9950429}.		inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]	cleavage furrow [GO:0032154]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; serotonin binding [GO:0051378]; serotonin-gated monoatomic cation-selective channel activity [GO:0022850]	cleavage furrow [GO:0032154]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; serotonin binding [GO:0051378]; serotonin-gated monoatomic cation-selective channel activity [GO:0022850]; inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:9950429}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23979}. Cell membrane {ECO:0000305|PubMed:9950429}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23979}.
P46100	reviewed	ATRX_HUMAN	Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)	ATRX RAD54L XH2	Homo sapiens (Human)	2492	FUNCTION: Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.		cellular response to hydroxyurea [GO:0072711]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA methylation [GO:0006306]; DNA repair [GO:0006281]; forebrain development [GO:0030900]; meiotic spindle organization [GO:0000212]; multicellular organism growth [GO:0035264]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; nucleosome assembly [GO:0006334]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomeric RNA transcription from RNA pol II promoter [GO:1901582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic forelimb morphogenesis [GO:0035128]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of DNA-templated transcription [GO:0006355]; replication fork processing [GO:0031297]; seminiferous tubule development [GO:0072520]; Sertoli cell development [GO:0060009]; spermatogenesis [GO:0007283]; subtelomeric heterochromatin formation [GO:0031509]; transcription by RNA polymerase II [GO:0006366]	chromosome, subtelomeric region [GO:0099115]; chromosome, telomeric region [GO:0000781]; condensed chromosome, centromeric region [GO:0000779]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; PML body [GO:0016605]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; chromo shadow domain binding [GO:0070087]; DNA translocase activity [GO:0015616]; helicase activity [GO:0004386]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]	chromosome, subtelomeric region [GO:0099115]; chromosome, telomeric region [GO:0000781]; condensed chromosome, centromeric region [GO:0000779]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; PML body [GO:0016605]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; chromo shadow domain binding [GO:0070087]; DNA translocase activity [GO:0015616]; helicase activity [GO:0004386]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; cellular response to hydroxyurea [GO:0072711]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA methylation [GO:0006306]; DNA repair [GO:0006281]; forebrain development [GO:0030900]; meiotic spindle organization [GO:0000212]; multicellular organism growth [GO:0035264]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; nucleosome assembly [GO:0006334]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomeric RNA transcription from RNA pol II promoter [GO:1901582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic forelimb morphogenesis [GO:0035128]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of DNA-templated transcription [GO:0006355]; replication fork processing [GO:0031297]; seminiferous tubule development [GO:0072520]; Sertoli cell development [GO:0060009]; spermatogenesis [GO:0007283]; subtelomeric heterochromatin formation [GO:0031509]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus. Chromosome, telomere. Nucleus, PML body. Note=Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with CBX5/HP1 alpha. Colocalizes with histone H3.3, DAXX, HIRA and ASF1A at PML-nuclear bodies. Colocalizes with cohesin (SMC1 and SMC3) and MECP2 at the maternal H19 ICR (By similarity). {ECO:0000250}.
P46108	reviewed	CRK_HUMAN	Adapter molecule crk (Proto-oncogene c-Crk) (p38)	CRK	Homo sapiens (Human)	304	FUNCTION: Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}.		actin cytoskeleton organization [GO:0030036]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cellular response to endothelin [GO:1990859]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to nitric oxide [GO:0071732]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cerebellar neuron development [GO:0098749]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; ephrin receptor signaling pathway [GO:0048013]; establishment of cell polarity [GO:0030010]; helper T cell diapedesis [GO:0035685]; hippocampus development [GO:0021766]; lipid metabolic process [GO:0006629]; negative regulation of cell motility [GO:2000146]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of wound healing [GO:0061045]; neuron migration [GO:0001764]; positive regulation of cell growth [GO:0030307]; positive regulation of JNK cascade [GO:0046330]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic specialization assembly [GO:0098698]; protein localization to membrane [GO:0072657]; reelin-mediated signaling pathway [GO:0038026]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell shape [GO:0008360]; regulation of dendrite development [GO:0050773]; regulation of GTPase activity [GO:0043087]; regulation of intracellular signal transduction [GO:1902531]; regulation of protein binding [GO:0043393]; regulation of Rac protein signal transduction [GO:0035020]; regulation of signal transduction [GO:0009966]; regulation of T cell migration [GO:2000404]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cholecystokinin [GO:0061847]; response to hepatocyte growth factor [GO:0035728]; response to hydrogen peroxide [GO:0042542]; response to yeast [GO:0001878]; signal transduction [GO:0007165]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	cytoskeletal protein binding [GO:0008092]; ephrin receptor binding [GO:0046875]; insulin-like growth factor receptor binding [GO:0005159]; kinase binding [GO:0019900]; phosphotyrosine residue binding [GO:0001784]; protein phosphorylated amino acid binding [GO:0045309]; protein self-association [GO:0043621]; protein tyrosine kinase binding [GO:1990782]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159]; ubiquitin protein ligase binding [GO:0031625]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; cytoskeletal protein binding [GO:0008092]; ephrin receptor binding [GO:0046875]; insulin-like growth factor receptor binding [GO:0005159]; kinase binding [GO:0019900]; phosphotyrosine residue binding [GO:0001784]; protein phosphorylated amino acid binding [GO:0045309]; protein self-association [GO:0043621]; protein tyrosine kinase binding [GO:1990782]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159]; ubiquitin protein ligase binding [GO:0031625]; actin cytoskeleton organization [GO:0030036]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cellular response to endothelin [GO:1990859]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to nitric oxide [GO:0071732]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cerebellar neuron development [GO:0098749]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; ephrin receptor signaling pathway [GO:0048013]; establishment of cell polarity [GO:0030010]; helper T cell diapedesis [GO:0035685]; hippocampus development [GO:0021766]; lipid metabolic process [GO:0006629]; negative regulation of cell motility [GO:2000146]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of wound healing [GO:0061045]; neuron migration [GO:0001764]; positive regulation of cell growth [GO:0030307]; positive regulation of JNK cascade [GO:0046330]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic specialization assembly [GO:0098698]; protein localization to membrane [GO:0072657]; reelin-mediated signaling pathway [GO:0038026]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell shape [GO:0008360]; regulation of dendrite development [GO:0050773]; regulation of GTPase activity [GO:0043087]; regulation of intracellular signal transduction [GO:1902531]; regulation of protein binding [GO:0043393]; regulation of Rac protein signal transduction [GO:0035020]; regulation of signal transduction [GO:0009966]; regulation of T cell migration [GO:2000404]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cholecystokinin [GO:0061847]; response to hepatocyte growth factor [GO:0035728]; response to hydrogen peroxide [GO:0042542]; response to yeast [GO:0001878]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.
P46109	reviewed	CRKL_HUMAN	Crk-like protein	CRKL	Homo sapiens (Human)	303	FUNCTION: May mediate the transduction of intracellular signals.		acetylcholine receptor signaling pathway [GO:0095500]; anterior/posterior pattern specification [GO:0009952]; B cell apoptotic process [GO:0001783]; blood vessel development [GO:0001568]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cellular response to interleukin-7 [GO:0098761]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to xenobiotic stimulus [GO:0071466]; cerebellar neuron development [GO:0098749]; cerebral cortex development [GO:0021987]; cranial skeletal system development [GO:1904888]; dendrite development [GO:0016358]; endothelin receptor signaling pathway [GO:0086100]; establishment of cell polarity [GO:0030010]; fibroblast growth factor receptor signaling pathway [GO:0008543]; helper T cell diapedesis [GO:0035685]; hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; lipid metabolic process [GO:0006629]; male gonad development [GO:0008584]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; parathyroid gland development [GO:0060017]; pharynx development [GO:0060465]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glial cell migration [GO:1903977]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic specialization assembly [GO:0098698]; Ras protein signal transduction [GO:0007265]; reelin-mediated signaling pathway [GO:0038026]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell growth [GO:0001558]; regulation of dendrite development [GO:0050773]; regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904393]; regulation of T cell migration [GO:2000404]; retinoic acid receptor signaling pathway [GO:0048384]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; urogenital system development [GO:0001655]	cytosol [GO:0005829]; extrinsic component of postsynaptic membrane [GO:0098890]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling adaptor activity [GO:0035591]	cytosol [GO:0005829]; extrinsic component of postsynaptic membrane [GO:0098890]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling adaptor activity [GO:0035591]; acetylcholine receptor signaling pathway [GO:0095500]; anterior/posterior pattern specification [GO:0009952]; B cell apoptotic process [GO:0001783]; blood vessel development [GO:0001568]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cellular response to interleukin-7 [GO:0098761]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to xenobiotic stimulus [GO:0071466]; cerebellar neuron development [GO:0098749]; cerebral cortex development [GO:0021987]; cranial skeletal system development [GO:1904888]; dendrite development [GO:0016358]; endothelin receptor signaling pathway [GO:0086100]; establishment of cell polarity [GO:0030010]; fibroblast growth factor receptor signaling pathway [GO:0008543]; helper T cell diapedesis [GO:0035685]; hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; lipid metabolic process [GO:0006629]; male gonad development [GO:0008584]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; parathyroid gland development [GO:0060017]; pharynx development [GO:0060465]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glial cell migration [GO:1903977]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic specialization assembly [GO:0098698]; Ras protein signal transduction [GO:0007265]; reelin-mediated signaling pathway [GO:0038026]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell growth [GO:0001558]; regulation of dendrite development [GO:0050773]; regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904393]; regulation of T cell migration [GO:2000404]; retinoic acid receptor signaling pathway [GO:0048384]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; urogenital system development [GO:0001655]	
P46199	reviewed	IF2M_HUMAN	Translation initiation factor IF-2, mitochondrial (IF-2(Mt)) (IF-2Mt) (IF2(mt))	MTIF2	Homo sapiens (Human)	727	FUNCTION: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.		mitochondrial translational initiation [GO:0070124]; regulation of translational initiation [GO:0006446]; ribosome disassembly [GO:0032790]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; mitochondrial translational initiation [GO:0070124]; regulation of translational initiation [GO:0006446]; ribosome disassembly [GO:0032790]	SUBCELLULAR LOCATION: Mitochondrion.
P46379	reviewed	BAG6_HUMAN	Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe)	BAG6 BAT3 G3	Homo sapiens (Human)	1132	FUNCTION: ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:28104892, PubMed:27193484). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}.		apoptotic process [GO:0006915]; brain development [GO:0007420]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; ER-associated misfolded protein catabolic process [GO:0071712]; immune response-activating cell surface receptor signaling pathway [GO:0002429]; internal peptidyl-lysine acetylation [GO:0018393]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; lung development [GO:0030324]; maintenance of unfolded protein involved in ERAD pathway [GO:1904378]; natural killer cell activation [GO:0030101]; negative regulation of apoptotic process [GO:0043066]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of proteolysis [GO:0045861]; positive regulation of ERAD pathway [GO:1904294]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; proteasomal protein catabolic process [GO:0010498]; protein localization to cytosolic proteasome complex involved in ERAD pathway [GO:1904379]; protein stabilization [GO:0050821]; regulation of embryonic development [GO:0045995]; regulation of protein stability [GO:0031647]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	BAT3 complex [GO:0071818]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; misfolded protein binding [GO:0051787]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; ribosome binding [GO:0043022]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-specific protease binding [GO:1990381]	BAT3 complex [GO:0071818]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; misfolded protein binding [GO:0051787]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; ribosome binding [GO:0043022]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-specific protease binding [GO:1990381]; apoptotic process [GO:0006915]; brain development [GO:0007420]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; ER-associated misfolded protein catabolic process [GO:0071712]; immune response-activating cell surface receptor signaling pathway [GO:0002429]; internal peptidyl-lysine acetylation [GO:0018393]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; lung development [GO:0030324]; maintenance of unfolded protein involved in ERAD pathway [GO:1904378]; natural killer cell activation [GO:0030101]; negative regulation of apoptotic process [GO:0043066]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of proteolysis [GO:0045861]; positive regulation of ERAD pathway [GO:1904294]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; proteasomal protein catabolic process [GO:0010498]; protein localization to cytosolic proteasome complex involved in ERAD pathway [GO:1904379]; protein stabilization [GO:0050821]; regulation of embryonic development [GO:0045995]; regulation of protein stability [GO:0031647]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:29042515}. Nucleus {ECO:0000269|PubMed:14960581, ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:29042515}. Secreted, extracellular exosome {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}. Note=Normally localized in cytosol and nucleus, it can also be released extracellularly, in exosomes, by tumor and myeloid dendritic cells (PubMed:18055229, PubMed:18852879). Cytoplasmic retention is due to interaction with GET4 (PubMed:29042515). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879, ECO:0000269|PubMed:29042515}.
P46439	reviewed	GSTM5_HUMAN	Glutathione S-transferase Mu 5 (EC 2.5.1.18) (GST class-mu 5) (GSTM5-5)	GSTM5	Homo sapiens (Human)	218	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000269|PubMed:10587441}.		glutathione metabolic process [GO:0006749]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]	glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; glutathione metabolic process [GO:0006749]	SUBCELLULAR LOCATION: Cytoplasm.
P46459	reviewed	NSF_HUMAN	Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF)	NSF	Homo sapiens (Human)	744	FUNCTION: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}.		exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; plasma membrane fusion [GO:0045026]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of receptor recycling [GO:0001921]; potassium ion transport [GO:0006813]; regulation of exocytosis [GO:0017157]; SNARE complex disassembly [GO:0035494]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; dendritic shaft [GO:0043198]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]	cytosol [GO:0005829]; dendritic shaft [GO:0043198]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; plasma membrane fusion [GO:0045026]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of receptor recycling [GO:0001921]; potassium ion transport [GO:0006813]; regulation of exocytosis [GO:0017157]; SNARE complex disassembly [GO:0035494]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm.
P46527	reviewed	CDN1B_HUMAN	Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)	CDKN1B KIP1 p27	Homo sapiens (Human)	198	FUNCTION: Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005, ECO:0000269|PubMed:28666995}.	MISCELLANEOUS: Decreased levels of p27Kip1, mainly due to proteasomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.	autophagic cell death [GO:0048102]; cellular response to antibiotic [GO:0071236]; cellular response to hypoxia [GO:0071456]; cellular response to lithium ion [GO:0071285]; cellular response to organic cyclic compound [GO:0071407]; cellular senescence [GO:0090398]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; epithelial cell apoptotic process [GO:1904019]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; G1/S transition of mitotic cell cycle [GO:0000082]; heart development [GO:0007507]; inner ear development [GO:0048839]; localization [GO:0051179]; negative regulation of cardiac muscle tissue regeneration [GO:1905179]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein kinase activity [GO:1904030]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of kinase activity [GO:0033673]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphorylation [GO:0042326]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; Notch signaling pathway [GO:0007219]; nuclear export [GO:0051168]; placenta development [GO:0001890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein phosphorylation [GO:0001934]; potassium ion transport [GO:0006813]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cell migration [GO:0030334]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of exit from mitosis [GO:0007096]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of lens fiber cell differentiation [GO:1902746]; response to amino acid [GO:0043200]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to glucose [GO:0009749]; response to peptide hormone [GO:0043434]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]	Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin binding [GO:0030332]; cyclin-dependent protein kinase activating kinase regulator activity [GO:0019914]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; Hsp70 protein binding [GO:0030544]; molecular adaptor activity [GO:0060090]; molecular function inhibitor activity [GO:0140678]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin protein ligase binding [GO:0031625]	Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin binding [GO:0030332]; cyclin-dependent protein kinase activating kinase regulator activity [GO:0019914]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; Hsp70 protein binding [GO:0030544]; molecular adaptor activity [GO:0060090]; molecular function inhibitor activity [GO:0140678]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin protein ligase binding [GO:0031625]; autophagic cell death [GO:0048102]; cellular response to antibiotic [GO:0071236]; cellular response to hypoxia [GO:0071456]; cellular response to lithium ion [GO:0071285]; cellular response to organic cyclic compound [GO:0071407]; cellular senescence [GO:0090398]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; epithelial cell apoptotic process [GO:1904019]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; G1/S transition of mitotic cell cycle [GO:0000082]; heart development [GO:0007507]; inner ear development [GO:0048839]; localization [GO:0051179]; negative regulation of cardiac muscle tissue regeneration [GO:1905179]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein kinase activity [GO:1904030]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of kinase activity [GO:0033673]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphorylation [GO:0042326]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; Notch signaling pathway [GO:0007219]; nuclear export [GO:0051168]; placenta development [GO:0001890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein phosphorylation [GO:0001934]; potassium ion transport [GO:0006813]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cell migration [GO:0030334]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of exit from mitosis [GO:0007096]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of lens fiber cell differentiation [GO:1902746]; response to amino acid [GO:0043200]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to glucose [GO:0009749]; response to peptide hormone [GO:0043434]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endosome {ECO:0000250}. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). {ECO:0000250}.
P46531	reviewed	NOTC1_HUMAN	Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]	NOTCH1 TAN1	Homo sapiens (Human)	2555	FUNCTION: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}.		animal organ regeneration [GO:0031100]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; arterial endothelial cell differentiation [GO:0060842]; astrocyte differentiation [GO:0048708]; atrioventricular node development [GO:0003162]; atrioventricular valve morphogenesis [GO:0003181]; auditory receptor cell fate commitment [GO:0009912]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium-ion regulated exocytosis [GO:0017156]; cardiac atrium morphogenesis [GO:0003209]; cardiac chamber formation [GO:0003207]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right atrium morphogenesis [GO:0003213]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell differentiation in spinal cord [GO:0021515]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to hypoxia [GO:0071456]; cellular response to tumor cell [GO:0071228]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cilium assembly [GO:0060271]; collecting duct development [GO:0072044]; compartment pattern specification [GO:0007386]; coronary artery morphogenesis [GO:0060982]; coronary sinus valve morphogenesis [GO:0003182]; coronary vein morphogenesis [GO:0003169]; determination of left/right symmetry [GO:0007368]; distal tubule development [GO:0072017]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cell differentiation [GO:0060956]; endocardial cushion morphogenesis [GO:0003203]; endocardium development [GO:0003157]; endocardium morphogenesis [GO:0003160]; endoderm development [GO:0007492]; epidermal cell fate specification [GO:0009957]; epithelial cell fate commitment [GO:0072148]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; forebrain development [GO:0030900]; foregut morphogenesis [GO:0007440]; glomerular mesangial cell development [GO:0072144]; growth involved in heart morphogenesis [GO:0003241]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula morphogenesis [GO:0061384]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; immune response [GO:0006955]; in utero embryonic development [GO:0001701]; inflammatory response to antigenic stimulus [GO:0002437]; inhibition of neuroepithelial cell differentiation [GO:0002085]; interleukin-17-mediated signaling pathway [GO:0097400]; keratinocyte differentiation [GO:0030216]; left/right axis specification [GO:0070986]; liver development [GO:0001889]; lung development [GO:0030324]; luteolysis [GO:0001554]; mesenchymal cell development [GO:0014031]; mitral valve formation [GO:0003192]; negative regulation of anoikis [GO:2000811]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell proliferation involved in heart valve morphogenesis [GO:0003252]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neurogenesis [GO:0050768]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; neuroendocrine cell differentiation [GO:0061101]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270]; oligodendrocyte differentiation [GO:0048709]; outflow tract morphogenesis [GO:0003151]; pericardium morphogenesis [GO:0003344]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of viral genome replication [GO:0045070]; prostate gland epithelium morphogenesis [GO:0060740]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; pulmonary valve morphogenesis [GO:0003184]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768]; regulation of extracellular matrix assembly [GO:1901201]; regulation of somitogenesis [GO:0014807]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; retinal cone cell differentiation [GO:0042670]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spermatogenesis [GO:0007283]; sprouting angiogenesis [GO:0002040]; T-helper 17 type immune response [GO:0072538]; tissue regeneration [GO:0042246]; transcription by RNA polymerase II [GO:0006366]; tube formation [GO:0035148]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; venous endothelial cell differentiation [GO:0060843]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]	acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	calcium ion binding [GO:0005509]; chromatin DNA binding [GO:0031490]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; Notch binding [GO:0005112]; transcription coactivator activity [GO:0003713]; transcription regulator activator activity [GO:0140537]; transmembrane signaling receptor activity [GO:0004888]	acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; calcium ion binding [GO:0005509]; chromatin DNA binding [GO:0031490]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; Notch binding [GO:0005112]; transcription coactivator activity [GO:0003713]; transcription regulator activator activity [GO:0140537]; transmembrane signaling receptor activity [GO:0004888]; animal organ regeneration [GO:0031100]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; arterial endothelial cell differentiation [GO:0060842]; astrocyte differentiation [GO:0048708]; atrioventricular node development [GO:0003162]; atrioventricular valve morphogenesis [GO:0003181]; auditory receptor cell fate commitment [GO:0009912]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium-ion regulated exocytosis [GO:0017156]; cardiac atrium morphogenesis [GO:0003209]; cardiac chamber formation [GO:0003207]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right atrium morphogenesis [GO:0003213]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell differentiation in spinal cord [GO:0021515]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to hypoxia [GO:0071456]; cellular response to tumor cell [GO:0071228]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cilium assembly [GO:0060271]; collecting duct development [GO:0072044]; compartment pattern specification [GO:0007386]; coronary artery morphogenesis [GO:0060982]; coronary sinus valve morphogenesis [GO:0003182]; coronary vein morphogenesis [GO:0003169]; determination of left/right symmetry [GO:0007368]; distal tubule development [GO:0072017]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cell differentiation [GO:0060956]; endocardial cushion morphogenesis [GO:0003203]; endocardium development [GO:0003157]; endocardium morphogenesis [GO:0003160]; endoderm development [GO:0007492]; epidermal cell fate specification [GO:0009957]; epithelial cell fate commitment [GO:0072148]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; forebrain development [GO:0030900]; foregut morphogenesis [GO:0007440]; glomerular mesangial cell development [GO:0072144]; growth involved in heart morphogenesis [GO:0003241]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula morphogenesis [GO:0061384]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; immune response [GO:0006955]; in utero embryonic development [GO:0001701]; inflammatory response to antigenic stimulus [GO:0002437]; inhibition of neuroepithelial cell differentiation [GO:0002085]; interleukin-17-mediated signaling pathway [GO:0097400]; keratinocyte differentiation [GO:0030216]; left/right axis specification [GO:0070986]; liver development [GO:0001889]; lung development [GO:0030324]; luteolysis [GO:0001554]; mesenchymal cell development [GO:0014031]; mitral valve formation [GO:0003192]; negative regulation of anoikis [GO:2000811]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell proliferation involved in heart valve morphogenesis [GO:0003252]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neurogenesis [GO:0050768]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; neuroendocrine cell differentiation [GO:0061101]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270]; oligodendrocyte differentiation [GO:0048709]; outflow tract morphogenesis [GO:0003151]; pericardium morphogenesis [GO:0003344]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of viral genome replication [GO:0045070]; prostate gland epithelium morphogenesis [GO:0060740]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; pulmonary valve morphogenesis [GO:0003184]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768]; regulation of extracellular matrix assembly [GO:1901201]; regulation of somitogenesis [GO:0014807]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; retinal cone cell differentiation [GO:0042670]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spermatogenesis [GO:0007283]; sprouting angiogenesis [GO:0002040]; T-helper 17 type immune response [GO:0072538]; tissue regeneration [GO:0042246]; transcription by RNA polymerase II [GO:0006366]; tube formation [GO:0035148]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; venous endothelial cell differentiation [GO:0060843]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q01705}; Single-pass type I membrane protein {ECO:0000305|PubMed:30598546}.; SUBCELLULAR LOCATION: [Notch 1 intracellular domain]: Nucleus {ECO:0000250|UniProtKB:Q01705}. Note=Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10. {ECO:0000250|UniProtKB:Q01705}.
P46597	reviewed	ASMT_HUMAN	Acetylserotonin O-methyltransferase (EC 2.1.1.4) (Hydroxyindole O-methyltransferase) (HIOMT)	ASMT	Homo sapiens (Human)	345	FUNCTION: [Isoform 1]: Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). {ECO:0000269|PubMed:22775292}.; FUNCTION: [Isoform 2]: Does not show Acetylserotonin O-methyltransferase activity. {ECO:0000269|PubMed:22775292}.; FUNCTION: [Isoform 3]: Does not show Acetylserotonin O-methyltransferase activity. {ECO:0000269|PubMed:22775292}.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.; MISCELLANEOUS: [Isoform 3]: Includes part of a LINE-1 element. {ECO:0000305}.	indolalkylamine biosynthetic process [GO:0046219]; lipid metabolic process [GO:0006629]; melatonin biosynthetic process [GO:0030187]; methylation [GO:0032259]; translation [GO:0006412]	cytosol [GO:0005829]	acetylserotonin O-methyltransferase activity [GO:0017096]; identical protein binding [GO:0042802]; O-methyltransferase activity [GO:0008171]; protein homodimerization activity [GO:0042803]; S-methyltransferase activity [GO:0008172]	cytosol [GO:0005829]; acetylserotonin O-methyltransferase activity [GO:0017096]; identical protein binding [GO:0042802]; O-methyltransferase activity [GO:0008171]; protein homodimerization activity [GO:0042803]; S-methyltransferase activity [GO:0008172]; indolalkylamine biosynthetic process [GO:0046219]; lipid metabolic process [GO:0006629]; melatonin biosynthetic process [GO:0030187]; methylation [GO:0032259]; translation [GO:0006412]	
P46663	reviewed	BKRB1_HUMAN	B1 bradykinin receptor (B1R) (BK-1 receptor)	BDKRB1 BRADYB1	Homo sapiens (Human)	353	FUNCTION: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. {ECO:0000269|PubMed:8063797, ECO:0000269|PubMed:8660997}.		cell migration [GO:0016477]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell growth [GO:0030308]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	bradykinin receptor activity [GO:0004947]; peptide binding [GO:0042277]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; bradykinin receptor activity [GO:0004947]; peptide binding [GO:0042277]; cell migration [GO:0016477]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell growth [GO:0030308]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:8063797}; Multi-pass membrane protein {ECO:0000255}.
P46695	reviewed	IEX1_HUMAN	Radiation-inducible immediate-early gene IEX-1 (Differentiation-dependent gene 2 protein) (Protein DIF-2) (Immediate early protein GLY96) (Immediate early response 3 protein) (PACAP-responsive gene 1 protein) (Protein PRG1)	IER3 DIF2 IEX1 PRG1	Homo sapiens (Human)	156	FUNCTION: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. {ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:22565310}.		anatomical structure morphogenesis [GO:0009653]; apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; glycolytic process [GO:0006096]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of systemic arterial blood pressure [GO:0003085]; positive regulation of protein catabolic process [GO:0045732]; regulation of DNA repair [GO:0006282]; regulation of nucleocytoplasmic transport [GO:0046822]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to protozoan [GO:0001562]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]		cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; anatomical structure morphogenesis [GO:0009653]; apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; glycolytic process [GO:0006096]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of systemic arterial blood pressure [GO:0003085]; positive regulation of protein catabolic process [GO:0045732]; regulation of DNA repair [GO:0006282]; regulation of nucleocytoplasmic transport [GO:0046822]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to protozoan [GO:0001562]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12356731}; Single-pass type II membrane protein {ECO:0000269|PubMed:12356731}.
P46721	reviewed	SO1A2_HUMAN	Solute carrier organic anion transporter family member 1A2 (OATP1A2) (OATP-A) (Organic anion-transporting polypeptide 1) (OATP-1) (Sodium-independent organic anion transporter) (Solute carrier family 21 member 3)	SLCO1A2 OATP OATP1 OATP1A2 SLC21A3	Homo sapiens (Human)	670	FUNCTION: Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane (PubMed:7557095, PubMed:19129463). Responsible for intestinal absorption of bile acids (By similarity). Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate) (PubMed:9539145, PubMed:23918469, PubMed:25560245, PubMed:12568656, PubMed:11159893, PubMed:19129463). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision (PubMed:25560245). Involved in the uptake of clinically used drugs (PubMed:17301733, PubMed:20686826, PubMed:27777271). Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) (PubMed:20358049, PubMed:19129463). Also transports prostaglandin E2 (PubMed:19129463). Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000250|UniProtKB:O88397, ECO:0000250|UniProtKB:Q91YY5, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:12568656, ECO:0000269|PubMed:17301733, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20358049, ECO:0000269|PubMed:20686826, ECO:0000269|PubMed:23243220, ECO:0000269|PubMed:23918469, ECO:0000269|PubMed:25132355, ECO:0000269|PubMed:25560245, ECO:0000269|PubMed:27777271, ECO:0000269|PubMed:7557095, ECO:0000269|PubMed:9539145, ECO:0000305|PubMed:35307651}.		bile acid and bile salt transport [GO:0015721]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; xenobiotic metabolic process [GO:0006805]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]	bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; transmembrane transporter activity [GO:0022857]; bile acid and bile salt transport [GO:0015721]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15632119, ECO:0000269|PubMed:25132355}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basal membrane of Sertoli cells. {ECO:0000269|PubMed:35307651}.
P46734	reviewed	MP2K3_HUMAN	Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)	MAP2K3 MEK3 MKK3 PRKMK3 SKK2	Homo sapiens (Human)	347	FUNCTION: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}.		cardiac muscle contraction [GO:0060048]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to sorbitol [GO:0072709]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular senescence [GO:0090398]; heart development [GO:0007507]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; negative regulation of hippo signaling [GO:0035331]; p38MAPK cascade [GO:0038066]; phosphorylation [GO:0016310]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of protein kinase activity [GO:0045860]; regulation of cytokine production [GO:0001817]; response to ischemia [GO:0002931]; signal transduction [GO:0007165]; stress-activated protein kinase signaling cascade [GO:0031098]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; cardiac muscle contraction [GO:0060048]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to sorbitol [GO:0072709]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular senescence [GO:0090398]; heart development [GO:0007507]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; negative regulation of hippo signaling [GO:0035331]; p38MAPK cascade [GO:0038066]; phosphorylation [GO:0016310]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of protein kinase activity [GO:0045860]; regulation of cytokine production [GO:0001817]; response to ischemia [GO:0002931]; signal transduction [GO:0007165]; stress-activated protein kinase signaling cascade [GO:0031098]	
P46736	reviewed	BRCC3_HUMAN	Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)	BRCC3 BRCC36 C6.1A CXorf53	Homo sapiens (Human)	316	FUNCTION: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) (PubMed:14636569, PubMed:19202061, PubMed:16707425, PubMed:17525341, PubMed:19261748, PubMed:19261749, PubMed:19261746). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26195665, PubMed:26344097). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (By similarity). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (By similarity). {ECO:0000250|UniProtKB:P46737, ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:16707425, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26344097}.		cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of DNA repair [GO:0045739]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein K63-linked deubiquitination [GO:0070536]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]; response to X-ray [GO:0010165]	BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151]	cysteine-type deubiquitinase activity [GO:0004843]; enzyme regulator activity [GO:0030234]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; polyubiquitin modification-dependent protein binding [GO:0031593]	BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151]; cysteine-type deubiquitinase activity [GO:0004843]; enzyme regulator activity [GO:0030234]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; polyubiquitin modification-dependent protein binding [GO:0031593]; cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of DNA repair [GO:0045739]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein K63-linked deubiquitination [GO:0070536]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]; response to X-ray [GO:0010165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26344097}. Cytoplasm {ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000305|PubMed:26195665}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:20656690, PubMed:26344097). Interaction with ABRAXAS2 retains BRCC3 in the cytoplasm (PubMed:20656690). {ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:26344097}.
P46776	reviewed	RL27A_HUMAN	Large ribosomal subunit protein uL15 (60S ribosomal protein L27a)	RPL27A	Homo sapiens (Human)	148	FUNCTION: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P46777	reviewed	RL5_HUMAN	Large ribosomal subunit protein uL18 (60S ribosomal protein L5)	RPL5 MSTP030	Homo sapiens (Human)	297	FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868, PubMed:23636399). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). {ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:24120868}.		cytoplasmic translation [GO:0002181]; negative regulation of protein neddylation [GO:2000435]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of gene expression [GO:0010628]; positive regulation of translation [GO:0045727]; protein stabilization [GO:0050821]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]	5S rRNA binding [GO:0008097]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; 5S rRNA binding [GO:0008097]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625]; cytoplasmic translation [GO:0002181]; negative regulation of protein neddylation [GO:2000435]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of gene expression [GO:0010628]; positive regulation of translation [GO:0045727]; protein stabilization [GO:0050821]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15469983, ECO:0000269|Ref.7}. Nucleus, nucleolus {ECO:0000269|PubMed:15469983, ECO:0000269|Ref.7}. Note=Although RP5 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL5 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. {ECO:0000269|PubMed:9687515}.
P46778	reviewed	RL21_HUMAN	Large ribosomal subunit protein eL21 (60S ribosomal protein L21)	RPL21	Homo sapiens (Human)	160	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P49666}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P49666, ECO:0000269|PubMed:25957688}.
P46779	reviewed	RL28_HUMAN	Large ribosomal subunit protein eL28 (60S ribosomal protein L28)	RPL28	Homo sapiens (Human)	137	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P46781	reviewed	RS9_HUMAN	Small ribosomal subunit protein uS4 (40S ribosomal protein S9)	RPS9	Homo sapiens (Human)	194	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; positive regulation of cell population proliferation [GO:0008284]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202]	5.8S rRNA binding [GO:1990932]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; 5.8S rRNA binding [GO:1990932]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182]; cytoplasmic translation [GO:0002181]; positive regulation of cell population proliferation [GO:0008284]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:17289661}.
P46782	reviewed	RS5_HUMAN	Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)]	RPS5	Homo sapiens (Human)	204	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; regulation of translational fidelity [GO:0006450]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; regulation of translational fidelity [GO:0006450]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
P46783	reviewed	RS10_HUMAN	Small ribosomal subunit protein eS10 (40S ribosomal protein S10)	RPS10	Homo sapiens (Human)	165	FUNCTION: Component of the 40S ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). {ECO:0000269|PubMed:23636399}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:20159986}. Note=Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus. {ECO:0000269|PubMed:20159986}.
P46821	reviewed	MAP1B_HUMAN	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	MAP1B	Homo sapiens (Human)	2468	FUNCTION: Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.		axon extension [GO:0048675]; axonogenesis [GO:0007409]; cellular response to growth factor stimulus [GO:0071363]; cellular response to peptide hormone stimulus [GO:0071375]; dendrite development [GO:0016358]; developmental maturation [GO:0021700]; establishment of monopolar cell polarity [GO:0061162]; induction of synaptic plasticity by chemical substance [GO:0051915]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; negative regulation of intracellular transport [GO:0032387]; negative regulation of microtubule depolymerization [GO:0007026]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; odontoblast differentiation [GO:0071895]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of axon extension [GO:0045773]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuron differentiation [GO:0045666]; regulation of microtubule depolymerization [GO:0031114]; response to carbohydrate [GO:0009743]; response to estradiol [GO:0032355]; response to inorganic substance [GO:0010035]; response to insecticide [GO:0017085]; response to mechanical stimulus [GO:0009612]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416]	apical dendrite [GO:0097440]; axon [GO:0030424]; basal dendrite [GO:0097441]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; growth cone [GO:0030426]; hippocampal mossy fiber [GO:0097457]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; somatodendritic compartment [GO:0036477]; synapse [GO:0045202]; varicosity [GO:0043196]	actin binding [GO:0003779]; microtubule binding [GO:0008017]; phospholipid binding [GO:0005543]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]	apical dendrite [GO:0097440]; axon [GO:0030424]; basal dendrite [GO:0097441]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; growth cone [GO:0030426]; hippocampal mossy fiber [GO:0097457]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; somatodendritic compartment [GO:0036477]; synapse [GO:0045202]; varicosity [GO:0043196]; actin binding [GO:0003779]; microtubule binding [GO:0008017]; phospholipid binding [GO:0005543]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; cellular response to growth factor stimulus [GO:0071363]; cellular response to peptide hormone stimulus [GO:0071375]; dendrite development [GO:0016358]; developmental maturation [GO:0021700]; establishment of monopolar cell polarity [GO:0061162]; induction of synaptic plasticity by chemical substance [GO:0051915]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; negative regulation of intracellular transport [GO:0032387]; negative regulation of microtubule depolymerization [GO:0007026]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; odontoblast differentiation [GO:0071895]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of axon extension [GO:0045773]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuron differentiation [GO:0045666]; regulation of microtubule depolymerization [GO:0031114]; response to carbohydrate [GO:0009743]; response to estradiol [GO:0032355]; response to inorganic substance [GO:0010035]; response to insecticide [GO:0017085]; response to mechanical stimulus [GO:0009612]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18195017}. Cytoplasm {ECO:0000269|PubMed:18195017}. Synapse {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Colocalizes with DAPK1 in the microtubules and cortical actin fibers. {ECO:0000250}.; SUBCELLULAR LOCATION: [MAP1 light chain LC1]: Cytoplasm {ECO:0000250|UniProtKB:P14873}.
P46926	reviewed	GNPI1_HUMAN	Glucosamine-6-phosphate isomerase 1 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 1) (GNPDA 1) (GlcN6P deaminase 1) (Oscillin)	GNPDA1 GNPI HLN KIAA0060	Homo sapiens (Human)	289	FUNCTION: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis (PubMed:21807125, PubMed:26887390). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). {ECO:0000250|UniProtKB:Q64422, ECO:0000269|PubMed:21807125, ECO:0000269|PubMed:26887390}.		carbohydrate metabolic process [GO:0005975]; generation of precursor metabolites and energy [GO:0006091]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; single fertilization [GO:0007338]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; carbohydrate metabolic process [GO:0005975]; generation of precursor metabolites and energy [GO:0006091]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; single fertilization [GO:0007338]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
P46934	reviewed	NEDD4_HUMAN	E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)	NEDD4 KIAA0093 NEDD4-1 RPF1 PIG53	Homo sapiens (Human)	1319	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597, PubMed:21399620, PubMed:19920177). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (By similarity). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes (PubMed:21765395). Promotes ubiquitination of RAPGEF2 (PubMed:11598133). According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (By similarity). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (PubMed:20086093). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Ubiquitinates DAZAP2, leading to its proteasomal degradation (PubMed:11342538). Ubiquitinates POLR2A (PubMed:19920177). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (PubMed:32101753). {ECO:0000250|UniProtKB:P46935, ECO:0000269|PubMed:11342538, ECO:0000269|PubMed:11598133, ECO:0000269|PubMed:17218260, ECO:0000269|PubMed:18562292, ECO:0000269|PubMed:21399620, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:23644597, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:32101753}.; FUNCTION: (Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding. {ECO:0000269|PubMed:12559917, ECO:0000269|PubMed:18305167}.	MISCELLANEOUS: A cysteine residue is required for ubiquitin-thioester formation.	cellular response to UV [GO:0034644]; formation of structure involved in a symbiotic process [GO:0044111]; glucocorticoid receptor signaling pathway [GO:0042921]; innate immune response [GO:0045087]; lysosomal transport [GO:0007041]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; negative regulation of sodium ion transport [GO:0010766]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neuromuscular junction development [GO:0007528]; neuron projection development [GO:0031175]; positive regulation of nucleocytoplasmic transport [GO:0046824]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein catabolic process [GO:0045732]; progesterone receptor signaling pathway [GO:0050847]; protein K63-linked ubiquitination [GO:0070534]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; receptor catabolic process [GO:0032801]; receptor internalization [GO:0031623]; regulation of dendrite morphogenesis [GO:0048814]; regulation of macroautophagy [GO:0016241]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; regulation of synapse organization [GO:0050807]; response to calcium ion [GO:0051592]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]	apicolateral plasma membrane [GO:0016327]; cell cortex [GO:0005938]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]	beta-2 adrenergic receptor binding [GO:0031698]; enzyme binding [GO:0019899]; phosphoserine residue binding [GO:0050815]; phosphothreonine residue binding [GO:0050816]; proline-rich region binding [GO:0070064]; protein domain specific binding [GO:0019904]; RNA polymerase binding [GO:0070063]; sodium channel inhibitor activity [GO:0019871]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]	apicolateral plasma membrane [GO:0016327]; cell cortex [GO:0005938]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]; beta-2 adrenergic receptor binding [GO:0031698]; enzyme binding [GO:0019899]; phosphoserine residue binding [GO:0050815]; phosphothreonine residue binding [GO:0050816]; proline-rich region binding [GO:0070064]; protein domain specific binding [GO:0019904]; RNA polymerase binding [GO:0070063]; sodium channel inhibitor activity [GO:0019871]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; cellular response to UV [GO:0034644]; formation of structure involved in a symbiotic process [GO:0044111]; glucocorticoid receptor signaling pathway [GO:0042921]; innate immune response [GO:0045087]; lysosomal transport [GO:0007041]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; negative regulation of sodium ion transport [GO:0010766]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neuromuscular junction development [GO:0007528]; neuron projection development [GO:0031175]; positive regulation of nucleocytoplasmic transport [GO:0046824]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein catabolic process [GO:0045732]; progesterone receptor signaling pathway [GO:0050847]; protein K63-linked ubiquitination [GO:0070534]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; receptor catabolic process [GO:0032801]; receptor internalization [GO:0031623]; regulation of dendrite morphogenesis [GO:0048814]; regulation of macroautophagy [GO:0016241]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; regulation of synapse organization [GO:0050807]; response to calcium ion [GO:0051592]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11342538}. Nucleus {ECO:0000269|PubMed:11342538}. Cell membrane {ECO:0000250|UniProtKB:P46935}; Peripheral membrane protein {ECO:0000250|UniProtKB:P46935}. Note=Predominantly cytoplasmic but also located in the nucleus (PubMed:11342538). Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1 (PubMed:18819914). {ECO:0000250|UniProtKB:P46935, ECO:0000269|PubMed:11342538, ECO:0000269|PubMed:18819914}.
P46937	reviewed	YAP1_HUMAN	Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)	YAP1 YAP65	Homo sapiens (Human)	504	FUNCTION: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750). Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:30447097}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.	MISCELLANEOUS: [Isoform 9]: Highest expression in ovary and placenta, lowest in skeletal muscle and brain. {ECO:0000305}.	bud elongation involved in lung branching [GO:0060449]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle tissue regeneration [GO:0061026]; cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; cellular response to gamma radiation [GO:0071480]; cellular response to retinoic acid [GO:0071300]; contact inhibition [GO:0060242]; DNA damage response [GO:0006974]; embryonic heart tube morphogenesis [GO:0003143]; enterocyte differentiation [GO:1903703]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway [GO:0097191]; glandular epithelial cell differentiation [GO:0002067]; heart process [GO:0003015]; hippo signaling [GO:0035329]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; keratinocyte differentiation [GO:0030216]; lateral mesoderm development [GO:0048368]; lung epithelial cell differentiation [GO:0060487]; negative regulation of cilium assembly [GO:1902018]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; notochord development [GO:0030903]; organ growth [GO:0035265]; paraxial mesoderm development [GO:0048339]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; protein-containing complex assembly [GO:0065003]; regulation of keratinocyte proliferation [GO:0010837]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of neurogenesis [GO:0050767]; regulation of stem cell proliferation [GO:0072091]; response to progesterone [GO:0032570]; somatic stem cell population maintenance [GO:0035019]; tissue homeostasis [GO:0001894]; trophectodermal cell differentiation [GO:0001829]; vasculogenesis [GO:0001570]; wound healing [GO:0042060]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; female germ cell nucleus [GO:0001674]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TEAD-YAP complex [GO:0140552]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; proline-rich region binding [GO:0070064]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; female germ cell nucleus [GO:0001674]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TEAD-YAP complex [GO:0140552]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; proline-rich region binding [GO:0070064]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; bud elongation involved in lung branching [GO:0060449]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle tissue regeneration [GO:0061026]; cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; cellular response to gamma radiation [GO:0071480]; cellular response to retinoic acid [GO:0071300]; contact inhibition [GO:0060242]; DNA damage response [GO:0006974]; embryonic heart tube morphogenesis [GO:0003143]; enterocyte differentiation [GO:1903703]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway [GO:0097191]; glandular epithelial cell differentiation [GO:0002067]; heart process [GO:0003015]; hippo signaling [GO:0035329]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; keratinocyte differentiation [GO:0030216]; lateral mesoderm development [GO:0048368]; lung epithelial cell differentiation [GO:0060487]; negative regulation of cilium assembly [GO:1902018]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; notochord development [GO:0030903]; organ growth [GO:0035265]; paraxial mesoderm development [GO:0048339]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; protein-containing complex assembly [GO:0065003]; regulation of keratinocyte proliferation [GO:0010837]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of neurogenesis [GO:0050767]; regulation of stem cell proliferation [GO:0072091]; response to progesterone [GO:0032570]; somatic stem cell population maintenance [GO:0035019]; tissue homeostasis [GO:0001894]; trophectodermal cell differentiation [GO:0001829]; vasculogenesis [GO:0001570]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:29400695}. Nucleus {ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:28169360, ECO:0000269|PubMed:29400695, ECO:0000269|PubMed:30447097}. Cell junction {ECO:0000250|UniProtKB:P46938}. Note=Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288, PubMed:20048001). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288, PubMed:20048001). At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001, PubMed:25849865). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:25849865}.
P46939	reviewed	UTRN_HUMAN	Utrophin (Dystrophin-related protein 1) (DRP-1)	UTRN DMDL DRP1	Homo sapiens (Human)	3433	FUNCTION: May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform Up71]: =Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform Up140]: =Produced by alternative promoter usage. {ECO:0000305}.	muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; positive regulation of cell-matrix adhesion [GO:0001954]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; synaptic signaling [GO:0099536]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]	actin binding [GO:0003779]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]; vinculin binding [GO:0017166]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; actin binding [GO:0003779]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]; vinculin binding [GO:0017166]; zinc ion binding [GO:0008270]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; positive regulation of cell-matrix adhesion [GO:0001954]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; synaptic signaling [GO:0099536]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Neuromuscular junction.
P46940	reviewed	IQGA1_HUMAN	Ras GTPase-activating-like protein IQGAP1 (p195)	IQGAP1 KIAA0051	Homo sapiens (Human)	1657	FUNCTION: Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}.		cell migration [GO:0016477]; cellular response to calcium ion [GO:0071277]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast migration [GO:0010761]; mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479]; negative regulation of dephosphorylation [GO:0035305]; neuron projection extension [GO:1990138]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; podocyte development [GO:0072015]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860]; regulation of cytokine production [GO:0001817]; regulation of mitotic cell cycle [GO:0007346]; signal transduction [GO:0007165]	actin filament [GO:0005884]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; midbody [GO:0030496]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; ruffle [GO:0001726]; secretory granule membrane [GO:0030667]; slit diaphragm [GO:0036057]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase inhibitor activity [GO:0005095]; MAP-kinase scaffold activity [GO:0005078]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activator activity [GO:0043539]; S100 protein binding [GO:0044548]; small GTPase binding [GO:0031267]	actin filament [GO:0005884]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; midbody [GO:0030496]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; ruffle [GO:0001726]; secretory granule membrane [GO:0030667]; slit diaphragm [GO:0036057]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase inhibitor activity [GO:0005095]; MAP-kinase scaffold activity [GO:0005078]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activator activity [GO:0043539]; S100 protein binding [GO:0044548]; small GTPase binding [GO:0031267]; cell migration [GO:0016477]; cellular response to calcium ion [GO:0071277]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast migration [GO:0010761]; mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479]; negative regulation of dephosphorylation [GO:0035305]; neuron projection extension [GO:1990138]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; podocyte development [GO:0072015]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860]; regulation of cytokine production [GO:0001817]; regulation of mitotic cell cycle [GO:0007346]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:29033352}. Nucleus {ECO:0000269|PubMed:20883816, ECO:0000269|PubMed:29033352}. Cytoplasm {ECO:0000269|PubMed:20883816, ECO:0000269|PubMed:29033352}. Apical cell membrane {ECO:0000269|PubMed:35601831}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9JKF1}. Note=Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816). {ECO:0000269|PubMed:20883816}.
P46952	reviewed	3HAO_HUMAN	3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) (3-hydroxyanthranilate oxygenase) (3-HAO) (h3HAO) (3-hydroxyanthranilic acid dioxygenase) (HAD)	HAAO	Homo sapiens (Human)	286	FUNCTION: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. {ECO:0000255|HAMAP-Rule:MF_03019, ECO:0000269|PubMed:28792876, ECO:0000269|PubMed:7514594}.		'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; NAD biosynthetic process [GO:0009435]; neuron cellular homeostasis [GO:0070050]; quinolinate biosynthetic process [GO:0019805]; quinolinate metabolic process [GO:0046874]; response to cadmium ion [GO:0046686]; response to zinc ion [GO:0010043]; tryptophan catabolic process [GO:0006569]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	3-hydroxyanthranilate 3,4-dioxygenase activity [GO:0000334]; electron transfer activity [GO:0009055]; ferrous iron binding [GO:0008198]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; 3-hydroxyanthranilate 3,4-dioxygenase activity [GO:0000334]; electron transfer activity [GO:0009055]; ferrous iron binding [GO:0008198]; 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; NAD biosynthetic process [GO:0009435]; neuron cellular homeostasis [GO:0070050]; quinolinate biosynthetic process [GO:0019805]; quinolinate metabolic process [GO:0046874]; response to cadmium ion [GO:0046686]; response to zinc ion [GO:0010043]; tryptophan catabolic process [GO:0006569]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:7514594}.
P46976	reviewed	GLYG_HUMAN	Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186)	GYG1 GYG	Homo sapiens (Human)	350	FUNCTION: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. {ECO:0000269|PubMed:22160680, ECO:0000269|PubMed:30356213}.		glycogen biosynthetic process [GO:0005978]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]	glycogenin glucosyltransferase activity [GO:0008466]; glycosyltransferase activity [GO:0016757]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]; UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity [GO:0102751]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]; glycogenin glucosyltransferase activity [GO:0008466]; glycosyltransferase activity [GO:0016757]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]; UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity [GO:0102751]; glycogen biosynthetic process [GO:0005978]	
P46977	reviewed	STT3A_HUMAN	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) (B5) (Integral membrane protein 1) (Transmembrane protein TMC)	STT3A ITM1 TMC	Homo sapiens (Human)	705	FUNCTION: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667, PubMed:34653363). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A (PubMed:19167329). {ECO:0000250|UniProtKB:P39007, ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:31831667, ECO:0000269|PubMed:34653363}.		co-translational protein modification [GO:0043686]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; oligosaccharyltransferase III complex [GO:0035000]	dolichyl-diphosphooligosaccharide-protein glycotransferase activity [GO:0004579]; metal ion binding [GO:0046872]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; oligosaccharyltransferase III complex [GO:0035000]; dolichyl-diphosphooligosaccharide-protein glycotransferase activity [GO:0004579]; metal ion binding [GO:0046872]; co-translational protein modification [GO:0043686]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:12887896}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P46978}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P46978}.
P47211	reviewed	GALR1_HUMAN	Galanin receptor type 1 (GAL1-R) (GALR-1)	GALR1 GALNR GALNR1	Homo sapiens (Human)	349	FUNCTION: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. {ECO:0000269|PubMed:25691535, ECO:0000269|PubMed:7524088}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; negative regulation of adenylate cyclase activity [GO:0007194]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cortisol secretion [GO:0051464]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transcription by RNA polymerase II [GO:0045944]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; galanin receptor activity [GO:0004966]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; galanin receptor activity [GO:0004966]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; negative regulation of adenylate cyclase activity [GO:0007194]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cortisol secretion [GO:0051464]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P47224	reviewed	MSS4_HUMAN	Guanine nucleotide exchange factor MSS4 (Rab-interacting factor)	RABIF MSS4 RASGRF3	Homo sapiens (Human)	123	FUNCTION: Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1, RAB3A and RAB10, but is less active on these proteins than on the SEC4 protein (PubMed:31540829). Might play a general role in vesicular transport. {ECO:0000269|PubMed:31540829}.		membrane fusion [GO:0061025]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; membrane [GO:0016020]	guanyl-nucleotide exchange factor activity [GO:0005085]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; membrane [GO:0016020]; guanyl-nucleotide exchange factor activity [GO:0005085]; zinc ion binding [GO:0008270]; membrane fusion [GO:0061025]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]	
P47710	reviewed	CASA1_HUMAN	Alpha-S1-casein [Cleaved into: Casoxin-D]	CSN1S1 CASA CSN1	Homo sapiens (Human)	185	FUNCTION: Important role in the capacity of milk to transport calcium phosphate.; FUNCTION: Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.	MISCELLANEOUS: In milk, the alpha s1- and beta-caseins precipitate in presence of calcium (so-called calcium-sensitive caseins). Kappa-casein prevents the precipitation of the other caseins by calcium through the formation of large stable colloidal particles termed micelles.	response to 11-deoxycorticosterone [GO:1903496]; response to dehydroepiandrosterone [GO:1903494]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570]	extracellular region [GO:0005576]; extracellular space [GO:0005615]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; response to 11-deoxycorticosterone [GO:1903496]; response to dehydroepiandrosterone [GO:1903494]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570]	SUBCELLULAR LOCATION: Secreted.
P47712	reviewed	PA24A_HUMAN	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]	PLA2G4A CPLA2 PLA2G4	Homo sapiens (Human)	749	FUNCTION: Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121, PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:27642067, PubMed:18451993). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:7794891, PubMed:8619991, PubMed:9425121, PubMed:10358058, PubMed:17472963, PubMed:18451993). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:18451993, PubMed:7794891, PubMed:9425121, PubMed:10358058, PubMed:17472963). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}.		arachidonic acid metabolic process [GO:0019369]; arachidonic acid secretion [GO:0050482]; cellular response to antibiotic [GO:0071236]; establishment of localization in cell [GO:0051649]; glycerol metabolic process [GO:0006071]; glycerophospholipid catabolic process [GO:0046475]; icosanoid metabolic process [GO:0006690]; leukotriene biosynthetic process [GO:0019370]; monoacylglycerol biosynthetic process [GO:0006640]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylglycerol catabolic process [GO:0034478]; platelet activating factor biosynthetic process [GO:0006663]; positive regulation of macrophage activation [GO:0043032]; positive regulation of platelet activation [GO:0010572]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of T-helper 1 type immune response [GO:0002827]; prostaglandin biosynthetic process [GO:0001516]; regulation of cell population proliferation [GO:0042127]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; ceramide 1-phosphate binding [GO:1902387]; lysophospholipase activity [GO:0004622]; O-acyltransferase activity [GO:0008374]; phosphatidyl phospholipase B activity [GO:0102545]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; phospholipase A2 activity [GO:0004623]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; ceramide 1-phosphate binding [GO:1902387]; lysophospholipase activity [GO:0004622]; O-acyltransferase activity [GO:0008374]; phosphatidyl phospholipase B activity [GO:0102545]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; phospholipase A2 activity [GO:0004623]; arachidonic acid metabolic process [GO:0019369]; arachidonic acid secretion [GO:0050482]; cellular response to antibiotic [GO:0071236]; establishment of localization in cell [GO:0051649]; glycerol metabolic process [GO:0006071]; glycerophospholipid catabolic process [GO:0046475]; icosanoid metabolic process [GO:0006690]; leukotriene biosynthetic process [GO:0019370]; monoacylglycerol biosynthetic process [GO:0006640]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylglycerol catabolic process [GO:0034478]; platelet activating factor biosynthetic process [GO:0006663]; positive regulation of macrophage activation [GO:0043032]; positive regulation of platelet activation [GO:0010572]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of T-helper 1 type immune response [GO:0002827]; prostaglandin biosynthetic process [GO:0001516]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11375391}. Golgi apparatus membrane {ECO:0000269|PubMed:11375391}. Nucleus envelope. Note=Translocates to intracellular membranes in a calcium-dependent way. {ECO:0000269|PubMed:11375391}.
P47736	reviewed	RPGP1_HUMAN	Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1)	RAP1GAP KIAA0474 RAP1GA1	Homo sapiens (Human)	663	FUNCTION: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}.		adaptive immune response [GO:0002250]; cellular response to glial cell derived neurotrophic factor [GO:1990792]; negative regulation of microvillus assembly [GO:1903697]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of thyroid gland epithelial cell proliferation [GO:1904442]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; neuronal cell body [GO:0043025]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; adaptive immune response [GO:0002250]; cellular response to glial cell derived neurotrophic factor [GO:1990792]; negative regulation of microvillus assembly [GO:1903697]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of thyroid gland epithelial cell proliferation [GO:1904442]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein.
P47755	reviewed	CAZA2_HUMAN	F-actin-capping protein subunit alpha-2 (CapZ alpha-2)	CAPZA2	Homo sapiens (Human)	286	FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.		actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]; protein-containing complex assembly [GO:0065003]	actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cortical cytoskeleton [GO:0030863]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; F-actin capping protein complex [GO:0008290]; membrane [GO:0016020]	actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cortical cytoskeleton [GO:0030863]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; F-actin capping protein complex [GO:0008290]; membrane [GO:0016020]; actin filament binding [GO:0051015]; actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]; protein-containing complex assembly [GO:0065003]	
P47756	reviewed	CAPZB_HUMAN	F-actin-capping protein subunit beta (CapZ beta)	CAPZB	Homo sapiens (Human)	272	FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}.		actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cell morphogenesis [GO:0000902]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; negative regulation of filopodium assembly [GO:0051490]; regulation of cell morphogenesis [GO:0022604]; regulation of lamellipodium assembly [GO:0010591]	actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; sarcomere [GO:0030017]; Schaffer collateral - CA1 synapse [GO:0098685]; sperm connecting piece [GO:0097224]; WASH complex [GO:0071203]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]	actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; sarcomere [GO:0030017]; Schaffer collateral - CA1 synapse [GO:0098685]; sperm connecting piece [GO:0097224]; WASH complex [GO:0071203]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cell morphogenesis [GO:0000902]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; negative regulation of filopodium assembly [GO:0051490]; regulation of cell morphogenesis [GO:0022604]; regulation of lamellipodium assembly [GO:0010591]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A9XFX6}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:A9XFX6}.
P47804	reviewed	RGR_HUMAN	RPE-retinal G protein-coupled receptor	RGR	Homo sapiens (Human)	291	FUNCTION: Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.		cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; visual perception [GO:0007601]	plasma membrane [GO:0005886]	G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P47813	reviewed	IF1AX_HUMAN	Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (eIF1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)	EIF1AX EIF1A EIF4C	Homo sapiens (Human)	144	FUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:9732867). This protein enhances formation of the cap-proximal complex (PubMed:9732867). Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes (PubMed:9732867). After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:35732735). Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B (PubMed:35732735). Its globular part is located in the A site of the 40S ribosomal subunit (PubMed:35732735). Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). In contrast to yeast orthologs, does not bind EIF1 (PubMed:24319994). {ECO:0000269|PubMed:24319994, ECO:0000269|PubMed:35732735, ECO:0000269|PubMed:9732867}.		ribosome assembly [GO:0042255]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; multi-eIF complex [GO:0043614]	RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; multi-eIF complex [GO:0043614]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049]; ribosome assembly [GO:0042255]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P47869	reviewed	GBRA2_HUMAN	Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2)	GABRA2	Homo sapiens (Human)	451	FUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:29961870, PubMed:31032849). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:29961870, PubMed:31032849). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). {ECO:0000250|UniProtKB:P26048, ECO:0000269|PubMed:29961870, ECO:0000269|PubMed:31032849}.		chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; neurotransmitter transport [GO:0006836]; regulation of neurotransmitter levels [GO:0001505]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	axon [GO:0030424]; chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]	benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	axon [GO:0030424]; chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]; benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; neurotransmitter transport [GO:0006836]; regulation of neurotransmitter levels [GO:0001505]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P26048}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P26048}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P23576}. Cell projection, dendrite {ECO:0000250|UniProtKB:P26048}.
P47870	reviewed	GBRB2_HUMAN	Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2)	GABRB2	Homo sapiens (Human)	512	FUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:8264558, PubMed:19763268, PubMed:27789573, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). {ECO:0000250|UniProtKB:P63137, ECO:0000250|UniProtKB:P63138, ECO:0000269|PubMed:19763268, ECO:0000269|PubMed:23909897, ECO:0000269|PubMed:25489750, ECO:0000269|PubMed:27789573, ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:8264558}.		cellular response to histamine [GO:0071420]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; cochlea development [GO:0090102]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384]; synaptic transmission, GABAergic [GO:0051932]	chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]	chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; cellular response to histamine [GO:0071420]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; cochlea development [GO:0090102]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P63137}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:19763268, ECO:0000269|PubMed:8264558}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P63138}.
P47871	reviewed	GLR_HUMAN	Glucagon receptor (GL-R)	GCGR	Homo sapiens (Human)	477	FUNCTION: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451, ECO:0000269|PubMed:30294546, ECO:0000269|PubMed:32677665, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; cellular response to glucagon stimulus [GO:0071377]; cellular response to starvation [GO:0009267]; exocytosis [GO:0006887]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of gene expression [GO:0010628]; regulation of blood pressure [GO:0008217]; regulation of glycogen metabolic process [GO:0070873]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]	endosome [GO:0005768]; membrane [GO:0016020]; plasma membrane [GO:0005886]	glucagon receptor activity [GO:0004967]; guanyl-nucleotide exchange factor activity [GO:0005085]; peptide hormone binding [GO:0017046]	endosome [GO:0005768]; membrane [GO:0016020]; plasma membrane [GO:0005886]; glucagon receptor activity [GO:0004967]; guanyl-nucleotide exchange factor activity [GO:0005085]; peptide hormone binding [GO:0017046]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; cellular response to glucagon stimulus [GO:0071377]; cellular response to starvation [GO:0009267]; exocytosis [GO:0006887]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of gene expression [GO:0010628]; regulation of blood pressure [GO:0008217]; regulation of glycogen metabolic process [GO:0070873]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451, ECO:0000269|PubMed:30294546, ECO:0000269|PubMed:32677665, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}; Multi-pass membrane protein {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}. Note=Is rapidly internalized after ligand-binding. {ECO:0000269|PubMed:9287038}.
P47872	reviewed	SCTR_HUMAN	Secretin receptor (SCT-R)	SCTR	Homo sapiens (Human)	440	FUNCTION: Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:7612008, PubMed:25332973). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:P11384, ECO:0000250|UniProtKB:Q5FWI2, ECO:0000269|PubMed:7612008, ECO:0000303|PubMed:25332973}.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; diet induced thermogenesis [GO:0002024]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular water homeostasis [GO:0009992]; positive regulation of cAMP-mediated signaling [GO:0043950]; regulation of appetite [GO:0032098]; regulation of synaptic plasticity [GO:0048167]; response to nutrient levels [GO:0031667]	cytoplasmic microtubule [GO:0005881]; plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; secretin receptor activity [GO:0015055]	cytoplasmic microtubule [GO:0005881]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; secretin receptor activity [GO:0015055]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; diet induced thermogenesis [GO:0002024]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular water homeostasis [GO:0009992]; positive regulation of cAMP-mediated signaling [GO:0043950]; regulation of appetite [GO:0032098]; regulation of synaptic plasticity [GO:0048167]; response to nutrient levels [GO:0031667]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P23811}; Multi-pass membrane protein {ECO:0000255}.
P47895	reviewed	AL1A3_HUMAN	Retinaldehyde dehydrogenase 3 (RALDH-3) (RalDH3) (EC 1.2.1.36) (Aldehyde dehydrogenase 6) (Aldehyde dehydrogenase family 1 member A3) (ALDH1A3)	ALDH1A3 ALDH6	Homo sapiens (Human)	512	FUNCTION: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (By similarity) (PubMed:27759097). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (PubMed:27759097). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity). {ECO:0000250|UniProtKB:Q9JHW9, ECO:0000269|PubMed:27759097}.		apoptotic process [GO:0006915]; embryonic camera-type eye development [GO:0031076]; embryonic eye morphogenesis [GO:0048048]; face development [GO:0060324]; Harderian gland development [GO:0070384]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; neuromuscular process controlling balance [GO:0050885]; nucleus accumbens development [GO:0021768]; olfactory pit development [GO:0060166]; optic cup morphogenesis involved in camera-type eye development [GO:0002072]; positive regulation of apoptotic process [GO:0043065]; protein homotetramerization [GO:0051289]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; righting reflex [GO:0060013]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]; retinal dehydrogenase activity [GO:0001758]; thyroid hormone binding [GO:0070324]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]; retinal dehydrogenase activity [GO:0001758]; thyroid hormone binding [GO:0070324]; apoptotic process [GO:0006915]; embryonic camera-type eye development [GO:0031076]; embryonic eye morphogenesis [GO:0048048]; face development [GO:0060324]; Harderian gland development [GO:0070384]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; neuromuscular process controlling balance [GO:0050885]; nucleus accumbens development [GO:0021768]; olfactory pit development [GO:0060166]; optic cup morphogenesis involved in camera-type eye development [GO:0002072]; positive regulation of apoptotic process [GO:0043065]; protein homotetramerization [GO:0051289]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; righting reflex [GO:0060013]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9JHW9}.
P47897	reviewed	SYQ_HUMAN	Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS)	QARS1 QARS	Homo sapiens (Human)	775	FUNCTION: Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). {ECO:0000269|PubMed:24656866, ECO:0000269|PubMed:26869582}.		brain development [GO:0007420]; glutaminyl-tRNA aminoacylation [GO:0006425]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress-activated MAPK cascade [GO:0032873]; tRNA aminoacylation for protein translation [GO:0006418]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; brain development [GO:0007420]; glutaminyl-tRNA aminoacylation [GO:0006425]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress-activated MAPK cascade [GO:0032873]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}. Cytoplasm {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:24656866}.
P47898	reviewed	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A (5-HT-5) (5-HT-5A) (5-HT5A) (Serotonin receptor 5A)	HTR5A	Homo sapiens (Human)	357	FUNCTION: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hippocampus development [GO:0021766]; response to estradiol [GO:0032355]	dendrite [GO:0030425]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]	G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]	dendrite [GO:0030425]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hippocampus development [GO:0021766]; response to estradiol [GO:0032355]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P47900	reviewed	P2RY1_HUMAN	P2Y purinoceptor 1 (P2Y1) (ADP receptor) (Purinergic receptor)	P2RY1	Homo sapiens (Human)	373	FUNCTION: Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040). {ECO:0000269|PubMed:25822790, ECO:0000269|PubMed:9038354, ECO:0000269|PubMed:9442040}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; blood vessel diameter maintenance [GO:0097746]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ATP [GO:0071318]; cellular response to purine-containing compound [GO:0071415]; eating behavior [GO:0042755]; establishment of localization in cell [GO:0051649]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; G protein-coupled receptor signaling pathway [GO:0007186]; glial cell migration [GO:0008347]; monoatomic ion transport [GO:0006811]; negative regulation of norepinephrine secretion [GO:0010700]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of hormone secretion [GO:0046887]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of monoatomic ion transport [GO:0043270]; positive regulation of penile erection [GO:0060406]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle exocytosis [GO:2000300]; relaxation of muscle [GO:0090075]; response to growth factor [GO:0070848]; response to mechanical stimulus [GO:0009612]; signal transduction involved in regulation of gene expression [GO:0023019]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell surface [GO:0009986]; cilium [GO:0005929]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]	A1 adenosine receptor binding [GO:0031686]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; G protein-coupled ADP receptor activity [GO:0001621]; G protein-coupled ATP receptor activity [GO:0045031]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; protein heterodimerization activity [GO:0046982]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell surface [GO:0009986]; cilium [GO:0005929]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]; A1 adenosine receptor binding [GO:0031686]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; G protein-coupled ADP receptor activity [GO:0001621]; G protein-coupled ATP receptor activity [GO:0045031]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; protein heterodimerization activity [GO:0046982]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; blood vessel diameter maintenance [GO:0097746]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ATP [GO:0071318]; cellular response to purine-containing compound [GO:0071415]; eating behavior [GO:0042755]; establishment of localization in cell [GO:0051649]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; G protein-coupled receptor signaling pathway [GO:0007186]; glial cell migration [GO:0008347]; monoatomic ion transport [GO:0006811]; negative regulation of norepinephrine secretion [GO:0010700]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of hormone secretion [GO:0046887]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of monoatomic ion transport [GO:0043270]; positive regulation of penile erection [GO:0060406]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle exocytosis [GO:2000300]; relaxation of muscle [GO:0090075]; response to growth factor [GO:0070848]; response to mechanical stimulus [GO:0009612]; signal transduction involved in regulation of gene expression [GO:0023019]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25822790}; Multi-pass membrane protein {ECO:0000269|PubMed:25822790}.
P47901	reviewed	V1BR_HUMAN	Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor)	AVPR1B AVPR3 VPR3	Homo sapiens (Human)	424	FUNCTION: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.; FUNCTION: (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, may recognize and internalize the complex formed by AVP/Arg-vasopressin, SARS-CoV-2 spike protein and secreted ACE2 through DNM2/dynamin 2-dependent endocytosis. {ECO:0000269|PubMed:33713620}.		activation of phospholipase C activity [GO:0007202]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phospholipase A2 activity [GO:0032430]; positive regulation of vasoconstriction [GO:0045907]; regulation of cell population proliferation [GO:0042127]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; transport across blood-brain barrier [GO:0150104]; viral entry into host cell [GO:0046718]	endosome [GO:0005768]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	peptide binding [GO:0042277]; protein kinase C binding [GO:0005080]; vasopressin receptor activity [GO:0005000]	endosome [GO:0005768]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; peptide binding [GO:0042277]; protein kinase C binding [GO:0005080]; vasopressin receptor activity [GO:0005000]; activation of phospholipase C activity [GO:0007202]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phospholipase A2 activity [GO:0032430]; positive regulation of vasoconstriction [GO:0045907]; regulation of cell population proliferation [GO:0042127]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; transport across blood-brain barrier [GO:0150104]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33713620}; Multi-pass membrane protein {ECO:0000255}.
P47902	reviewed	CDX1_HUMAN	Homeobox protein CDX-1 (Caudal-type homeobox protein 1)	CDX1	Homo sapiens (Human)	265	FUNCTION: Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:28473536}.		animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; bone morphogenesis [GO:0060349]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of somitogenesis [GO:0014807]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; bone morphogenesis [GO:0060349]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of somitogenesis [GO:0014807]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P47914	reviewed	RL29_HUMAN	Large ribosomal subunit protein eL29 (60S ribosomal protein L29) (Cell surface heparin-binding protein HIP)	RPL29	Homo sapiens (Human)	159	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; embryo implantation [GO:0007566]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]	cadherin binding [GO:0045296]; heparin binding [GO:0008201]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; cadherin binding [GO:0045296]; heparin binding [GO:0008201]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; embryo implantation [GO:0007566]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P47928	reviewed	ID4_HUMAN	DNA-binding protein inhibitor ID-4 (Class B basic helix-loop-helix protein 27) (bHLHb27) (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4)	ID4 BHLHB27	Homo sapiens (Human)	161	FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). {ECO:0000250}.		astrocyte differentiation [GO:0048708]; cell differentiation [GO:0030154]; central nervous system myelination [GO:0022010]; cerebral cortex neuron differentiation [GO:0021895]; circadian regulation of gene expression [GO:0032922]; fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; hippocampus development [GO:0021766]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast proliferation [GO:0007405]; osteoblast differentiation [GO:0001649]; positive regulation of gene expression [GO:0010628]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland stromal morphogenesis [GO:0060741]; protein localization [GO:0008104]; seminal vesicle morphogenesis [GO:0061682]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein dimerization activity [GO:0046983]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator inhibitor activity [GO:0140416]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein dimerization activity [GO:0046983]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator inhibitor activity [GO:0140416]; astrocyte differentiation [GO:0048708]; cell differentiation [GO:0030154]; central nervous system myelination [GO:0022010]; cerebral cortex neuron differentiation [GO:0021895]; circadian regulation of gene expression [GO:0032922]; fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; hippocampus development [GO:0021766]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast proliferation [GO:0007405]; osteoblast differentiation [GO:0001649]; positive regulation of gene expression [GO:0010628]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland stromal morphogenesis [GO:0060741]; protein localization [GO:0008104]; seminal vesicle morphogenesis [GO:0061682]	SUBCELLULAR LOCATION: Nucleus.
P47929	reviewed	LEG7_HUMAN	Galectin-7 (Gal-7) (HKL-14) (PI7) (p53-induced gene 1 protein)	LGALS7 PIG1; LGALS7B	Homo sapiens (Human)	136	FUNCTION: Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. {ECO:0000269|PubMed:11706006}.		apoptotic process [GO:0006915]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]	carbohydrate binding [GO:0030246]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]; carbohydrate binding [GO:0030246]; apoptotic process [GO:0006915]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11706006}. Nucleus {ECO:0000269|PubMed:11706006}. Secreted {ECO:0000305}. Note=May be secreted by a non-classical secretory pathway.
P47974	reviewed	TISD_HUMAN	mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2)	ZFP36L2 ERF2 RNF162C TIS11D	Homo sapiens (Human)	494	FUNCTION: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; definitive hemopoiesis [GO:0060216]; ERK1 and ERK2 cascade [GO:0070371]; hemopoiesis [GO:0030097]; mRNA catabolic process [GO:0006402]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; negative regulation of stem cell differentiation [GO:2000737]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; regulation of B cell differentiation [GO:0045577]; regulation of mRNA stability [GO:0043488]; response to wounding [GO:0009611]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; T cell differentiation in thymus [GO:0033077]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; definitive hemopoiesis [GO:0060216]; ERK1 and ERK2 cascade [GO:0070371]; hemopoiesis [GO:0030097]; mRNA catabolic process [GO:0006402]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; negative regulation of stem cell differentiation [GO:2000737]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; regulation of B cell differentiation [GO:0045577]; regulation of mRNA stability [GO:0043488]; response to wounding [GO:0009611]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; T cell differentiation in thymus [GO:0033077]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34611029}. Cytoplasm {ECO:0000269|PubMed:34611029}. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. {ECO:0000250|UniProtKB:P23949}.
P47985	reviewed	UCRI_HUMAN	Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 7.1.1.8) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Rieske protein UQCRFS1) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 9 (Su9) (Subunit 9) (8 kDa subunit 9) (Complex III subunit IX) (Cytochrome b-c1 complex subunit 11) (UQCRFS1 mitochondrial targeting sequence) (UQCRFS1 MTS) (Ubiquinol-cytochrome c reductase 8 kDa protein)]	UQCRFS1	Homo sapiens (Human)	274	FUNCTION: [Cytochrome b-c1 complex subunit Rieske, mitochondrial]: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:31883641). The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (PubMed:28673544). {ECO:0000250|UniProtKB:P08067, ECO:0000269|PubMed:28673544, ECO:0000269|PubMed:31883641}.; FUNCTION: [Cytochrome b-c1 complex subunit 9]: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function. {ECO:0000269|PubMed:28673544}.	MISCELLANEOUS: The Rieske protein is a high potential 2Fe-2S protein.	mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; mitochondrial respiratory chain complex III assembly [GO:0034551]; respiratory electron transport chain [GO:0022904]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]	2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; ubiquinol-cytochrome-c reductase activity [GO:0008121]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; mitochondrial respiratory chain complex III assembly [GO:0034551]; respiratory electron transport chain [GO:0022904]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:31883641}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q5ZLR5}.
P47989	reviewed	XDH_HUMAN	Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)]	XDH XDHA	Homo sapiens (Human)	1333	FUNCTION: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). {ECO:0000269|PubMed:17301077}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; adenosine catabolic process [GO:0006154]; allantoin metabolic process [GO:0000255]; amide catabolic process [GO:0043605]; AMP catabolic process [GO:0006196]; dAMP catabolic process [GO:0046059]; deoxyadenosine catabolic process [GO:0006157]; deoxyguanosine catabolic process [GO:0006161]; deoxyinosine catabolic process [GO:0006149]; dGMP catabolic process [GO:0046055]; GMP catabolic process [GO:0046038]; guanine catabolic process [GO:0006147]; hypoxanthine catabolic process [GO:0009114]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; iron-sulfur cluster assembly [GO:0016226]; lactation [GO:0007595]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; negative regulation of vasculogenesis [GO:2001213]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; xanthine catabolic process [GO:0009115]	cytosol [GO:0005829]; extracellular space [GO:0005615]; peroxisome [GO:0005777]; sarcoplasmic reticulum [GO:0016529]	2 iron, 2 sulfur cluster binding [GO:0051537]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; hypoxanthine dehydrogenase activity [GO:0070674]; hypoxanthine oxidase activity [GO:0070675]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; protein homodimerization activity [GO:0042803]; xanthine dehydrogenase activity [GO:0004854]; xanthine oxidase activity [GO:0004855]	cytosol [GO:0005829]; extracellular space [GO:0005615]; peroxisome [GO:0005777]; sarcoplasmic reticulum [GO:0016529]; 2 iron, 2 sulfur cluster binding [GO:0051537]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; hypoxanthine dehydrogenase activity [GO:0070674]; hypoxanthine oxidase activity [GO:0070675]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; protein homodimerization activity [GO:0042803]; xanthine dehydrogenase activity [GO:0004854]; xanthine oxidase activity [GO:0004855]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; adenosine catabolic process [GO:0006154]; allantoin metabolic process [GO:0000255]; amide catabolic process [GO:0043605]; AMP catabolic process [GO:0006196]; dAMP catabolic process [GO:0046059]; deoxyadenosine catabolic process [GO:0006157]; deoxyguanosine catabolic process [GO:0006161]; deoxyinosine catabolic process [GO:0006149]; dGMP catabolic process [GO:0046055]; GMP catabolic process [GO:0046038]; guanine catabolic process [GO:0006147]; hypoxanthine catabolic process [GO:0009114]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; iron-sulfur cluster assembly [GO:0016226]; lactation [GO:0007595]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; negative regulation of vasculogenesis [GO:2001213]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; xanthine catabolic process [GO:0009115]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Peroxisome {ECO:0000250}. Secreted.
P47992	reviewed	XCL1_HUMAN	Lymphotactin (ATAC) (C motif chemokine 1) (Cytokine SCM-1) (Lymphotaxin) (SCM-1-alpha) (Small-inducible cytokine C1) (XC chemokine ligand 1)	XCL1 LTN SCYC1	Homo sapiens (Human)	114	FUNCTION: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. {ECO:0000250|UniProtKB:P47993}.		cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-4 [GO:0071353]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; mature natural killer cell chemotaxis [GO:0035782]; monocyte chemotaxis [GO:0002548]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T-helper 1 cell activation [GO:2000518]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of type II interferon production [GO:0032689]; neutrophil chemotaxis [GO:0030593]; positive regulation of B cell chemotaxis [GO:2000538]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granzyme A production [GO:2000513]; positive regulation of granzyme B production [GO:0071663]; positive regulation of immunoglobulin production in mucosal tissue [GO:2000558]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of natural killer cell chemotaxis [GO:2000503]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of thymocyte migration [GO:2000412]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of inflammatory response [GO:0050727]; release of sequestered calcium ion into cytosol [GO:0051209]; response to virus [GO:0009615]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]; protein homodimerization activity [GO:0042803]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]; protein homodimerization activity [GO:0042803]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-4 [GO:0071353]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; mature natural killer cell chemotaxis [GO:0035782]; monocyte chemotaxis [GO:0002548]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T-helper 1 cell activation [GO:2000518]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of type II interferon production [GO:0032689]; neutrophil chemotaxis [GO:0030593]; positive regulation of B cell chemotaxis [GO:2000538]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granzyme A production [GO:2000513]; positive regulation of granzyme B production [GO:0071663]; positive regulation of immunoglobulin production in mucosal tissue [GO:2000558]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of natural killer cell chemotaxis [GO:2000503]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of thymocyte migration [GO:2000412]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of inflammatory response [GO:0050727]; release of sequestered calcium ion into cytosol [GO:0051209]; response to virus [GO:0009615]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P48023	reviewed	TNFL6_HUMAN	Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]	FASLG APT1LG1 CD95L FASL TNFSF6	Homo sapiens (Human)	281	FUNCTION: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260). {ECO:0000250|UniProtKB:P41047, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:27806260, ECO:0000269|PubMed:7528780, ECO:0000269|PubMed:9228058, ECO:0000269|PubMed:9427603}.; FUNCTION: [Tumor necrosis factor ligand superfamily member 6, soluble form]: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process (PubMed:27806260). {ECO:0000250|UniProtKB:P41047, ECO:0000269|PubMed:27806260}.; FUNCTION: [FasL intracellular domain]: Cytoplasmic form induces gene transcription inhibition. {ECO:0000269|PubMed:17557115}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell-cell signaling [GO:0007267]; cellular response to type II interferon [GO:0071346]; endosomal lumen acidification [GO:0048388]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory cell apoptotic process [GO:0006925]; intracellular chloride ion homeostasis [GO:0030644]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of phosphatidylserine exposure on apoptotic cell surface [GO:1905782]; release of sequestered calcium ion into cytosol by endoplasmic reticulum [GO:1903514]; response to growth factor [GO:0070848]; response to lipopolysaccharide [GO:0032496]; retinal cell programmed cell death [GO:0046666]; signal transduction [GO:0007165]; T cell apoptotic process [GO:0070231]	caveola [GO:0005901]; cytoplasmic vesicle lumen [GO:0060205]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; death receptor binding [GO:0005123]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]	caveola [GO:0005901]; cytoplasmic vesicle lumen [GO:0060205]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; death receptor binding [GO:0005123]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell-cell signaling [GO:0007267]; cellular response to type II interferon [GO:0071346]; endosomal lumen acidification [GO:0048388]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory cell apoptotic process [GO:0006925]; intracellular chloride ion homeostasis [GO:0030644]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of phosphatidylserine exposure on apoptotic cell surface [GO:1905782]; release of sequestered calcium ion into cytosol by endoplasmic reticulum [GO:1903514]; response to growth factor [GO:0070848]; response to lipopolysaccharide [GO:0032496]; retinal cell programmed cell death [GO:0046666]; signal transduction [GO:0007165]; T cell apoptotic process [GO:0070231]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:9427603}; Single-pass type II membrane protein {ECO:0000255}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:17164290}. Lysosome lumen {ECO:0000269|PubMed:17164290}. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115). {ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:17557115}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted {ECO:0000269|PubMed:9427603}. Note=May be released into the extracellular fluid by cleavage from the cell surface. {ECO:0000269|PubMed:9427603}.; SUBCELLULAR LOCATION: [FasL intracellular domain]: Nucleus {ECO:0000269|PubMed:17557115}. Note=The FasL ICD cytoplasmic form is translocated into the nucleus. {ECO:0000269|PubMed:17557115}.
P48029	reviewed	SC6A8_HUMAN	Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8)	SLC6A8	Homo sapiens (Human)	635	FUNCTION: Creatine:sodium symporter which mediates the uptake of creatine (PubMed:7953292, PubMed:7945388, PubMed:9882430, PubMed:17465020, PubMed:22644605, PubMed:25861866). Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity). {ECO:0000250|UniProtKB:Q8VBW1, ECO:0000269|PubMed:17465020, ECO:0000269|PubMed:22644605, ECO:0000269|PubMed:25861866, ECO:0000269|PubMed:7945388, ECO:0000269|PubMed:7953292, ECO:0000269|PubMed:9882430}.		creatine metabolic process [GO:0006600]; creatine transmembrane transport [GO:0015881]; muscle contraction [GO:0006936]; neurotransmitter transport [GO:0006836]; nitrogen compound transport [GO:0071705]; sodium ion transmembrane transport [GO:0035725]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]	creatine transmembrane transporter activity [GO:0005308]; creatine:sodium symporter activity [GO:0005309]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]; creatine transmembrane transporter activity [GO:0005308]; creatine:sodium symporter activity [GO:0005309]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; creatine metabolic process [GO:0006600]; creatine transmembrane transport [GO:0015881]; muscle contraction [GO:0006936]; neurotransmitter transport [GO:0006836]; nitrogen compound transport [GO:0071705]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22644605}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12433955}; Multi-pass membrane protein {ECO:0000255}.
P48039	reviewed	MTR1A_HUMAN	Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)	MTNR1A	Homo sapiens (Human)	350	FUNCTION: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; mating behavior [GO:0007617]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; melatonin receptor activity [GO:0008502]; organic cyclic compound binding [GO:0097159]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; melatonin receptor activity [GO:0008502]; organic cyclic compound binding [GO:0097159]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; mating behavior [GO:0007617]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P48047	reviewed	ATPO_HUMAN	ATP synthase subunit O, mitochondrial (ATP synthase peripheral stalk subunit OSCP) (Oligomycin sensitivity conferral protein) (OSCP)	ATP5PO ATP5O ATPO	Homo sapiens (Human)	213	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.		ATP biosynthetic process [GO:0006754]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, stator stalk [GO:0000274]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]	proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, stator stalk [GO:0000274]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; ATP biosynthetic process [GO:0006754]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}.
P48048	reviewed	KCNJ1_HUMAN	ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1)	KCNJ1 ROMK1	Homo sapiens (Human)	391	FUNCTION: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. {ECO:0000269|PubMed:7929082}.		potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765]	plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; inward rectifier potassium channel activity [GO:0005242]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; inward rectifier potassium channel activity [GO:0005242]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12684516}; Multi-pass membrane protein {ECO:0000269|PubMed:12684516}. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. {ECO:0000269|PubMed:12684516}.
P48050	reviewed	KCNJ4_HUMAN	Inward rectifier potassium channel 4 (HIRK2) (HRK1) (Hippocampal inward rectifier) (HIR) (Inward rectifier K(+) channel Kir2.3) (IRK-3) (Potassium channel, inwardly rectifying subfamily J member 4)	KCNJ4 IRK3	Homo sapiens (Human)	445	FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). {ECO:0000250}.		potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]	basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076]	inward rectifier potassium channel activity [GO:0005242]; PDZ domain binding [GO:0030165]	basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076]; inward rectifier potassium channel activity [GO:0005242]; PDZ domain binding [GO:0030165]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization. {ECO:0000250}.
P48051	reviewed	KCNJ6_HUMAN	G protein-activated inward rectifier potassium channel 2 (GIRK-2) (BIR1) (Inward rectifier K(+) channel Kir3.2) (KATP-2) (Potassium channel, inwardly rectifying subfamily J member 6)	KCNJ6 GIRK2 KATP2 KCNJ7	Homo sapiens (Human)	423	FUNCTION: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.		potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P48052	reviewed	CBPA2_HUMAN	Carboxypeptidase A2 (EC 3.4.17.15)	CPA2	Homo sapiens (Human)	419			protein catabolic process in the vacuole [GO:0007039]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; vacuole [GO:0005773]	carboxypeptidase activity [GO:0004180]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; vacuole [GO:0005773]; carboxypeptidase activity [GO:0004180]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; protein catabolic process in the vacuole [GO:0007039]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
P48058	reviewed	GRIA4_HUMAN	Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4)	GRIA4 GLUR4	Homo sapiens (Human)	902	FUNCTION: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:21172611}.	MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.	glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; synaptic transmission, glutamatergic [GO:0035249]	AMPA glutamate receptor complex [GO:0032281]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; extracellular vesicle [GO:1903561]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; ionotropic glutamate receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	AMPA glutamate receptor complex [GO:0032281]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; extracellular vesicle [GO:1903561]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; ionotropic glutamate receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression. {ECO:0000250}.
P48059	reviewed	LIMS1_HUMAN	LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48)	LIMS1 PINCH PINCH1	Homo sapiens (Human)	325	FUNCTION: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.		cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cellular response to transforming growth factor beta stimulus [GO:0071560]; establishment of protein localization [GO:0045184]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270]; cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cellular response to transforming growth factor beta stimulus [GO:0071560]; establishment of protein localization [GO:0045184]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
P48061	reviewed	SDF1_HUMAN	Stromal cell-derived factor 1 (SDF-1) (hSDF-1) (C-X-C motif chemokine 12) (Intercrine reduced in hepatomas) (IRH) (hIRH) (Pre-B cell growth-stimulating factor) (PBSF) [Cleaved into: SDF-1-beta(3-72); SDF-1-alpha(3-67)]	CXCL12 SDF1 SDF1A SDF1B	Homo sapiens (Human)	93	FUNCTION: Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity). {ECO:0000250|UniProtKB:P40224, ECO:0000269|PubMed:11069075, ECO:0000269|PubMed:11859124, ECO:0000269|PubMed:16107333, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19255243, ECO:0000269|PubMed:29301984, ECO:0000269|PubMed:8752281}.		adult locomotory behavior [GO:0008344]; animal organ regeneration [GO:0031100]; axon guidance [GO:0007411]; blood circulation [GO:0008015]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cellular response to chemokine [GO:1990869]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; defense response [GO:0006952]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; induction of positive chemotaxis [GO:0050930]; integrin activation [GO:0033622]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of leukocyte tethering or rolling [GO:1903237]; neuron migration [GO:0001764]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of T cell migration [GO:2000406]; regulation of actin polymerization or depolymerization [GO:0008064]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; response to ultrasound [GO:1990478]; response to virus [GO:0009615]; signal transduction [GO:0007165]; telencephalon cell migration [GO:0022029]	collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]; CXCR chemokine receptor binding [GO:0045236]; growth factor activity [GO:0008083]; integrin binding [GO:0005178]; signaling receptor binding [GO:0005102]	collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]; CXCR chemokine receptor binding [GO:0045236]; growth factor activity [GO:0008083]; integrin binding [GO:0005178]; signaling receptor binding [GO:0005102]; adult locomotory behavior [GO:0008344]; animal organ regeneration [GO:0031100]; axon guidance [GO:0007411]; blood circulation [GO:0008015]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cellular response to chemokine [GO:1990869]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; defense response [GO:0006952]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; induction of positive chemotaxis [GO:0050930]; integrin activation [GO:0033622]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of leukocyte tethering or rolling [GO:1903237]; neuron migration [GO:0001764]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of T cell migration [GO:2000406]; regulation of actin polymerization or depolymerization [GO:0008064]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; response to ultrasound [GO:1990478]; response to virus [GO:0009615]; signal transduction [GO:0007165]; telencephalon cell migration [GO:0022029]	SUBCELLULAR LOCATION: Secreted.
P48065	reviewed	S6A12_HUMAN	Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12)	SLC6A12 BGT1	Homo sapiens (Human)	614	FUNCTION: Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation (By similarity). {ECO:0000250|UniProtKB:P31651, ECO:0000269|PubMed:7589472}.		amino acid transport [GO:0006865]; gamma-aminobutyric acid reuptake [GO:0051936]; gamma-aminobutyric acid transport [GO:0015812]; glycine betaine transport [GO:0031460]; monocarboxylic acid transport [GO:0015718]; sodium ion transmembrane transport [GO:0035725]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; monocarboxylic acid transmembrane transporter activity [GO:0008028]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; amino acid transport [GO:0006865]; gamma-aminobutyric acid reuptake [GO:0051936]; gamma-aminobutyric acid transport [GO:0015812]; glycine betaine transport [GO:0031460]; monocarboxylic acid transport [GO:0015718]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:P31651}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P31651}; Multi-pass membrane protein {ECO:0000255}. Note=In kidney, locates in basolateral membranes of renal medulla. In liver, locates in hepatocytes cell membrane. {ECO:0000250|UniProtKB:P31651}.
P48066	reviewed	S6A11_HUMAN	Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11)	SLC6A11 GABT3 GAT3	Homo sapiens (Human)	632	FUNCTION: Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:7874447). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity). {ECO:0000250|UniProtKB:P31650, ECO:0000269|PubMed:7874447}.		gamma-aminobutyric acid reuptake [GO:0051936]; monocarboxylic acid transport [GO:0015718]; response to xenobiotic stimulus [GO:0009410]; sodium ion transmembrane transport [GO:0035725]	cell projection [GO:0042995]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; neurotransmitter binding [GO:0042165]; taurine:sodium symporter activity [GO:0005369]	cell projection [GO:0042995]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; neurotransmitter binding [GO:0042165]; taurine:sodium symporter activity [GO:0005369]; gamma-aminobutyric acid reuptake [GO:0051936]; monocarboxylic acid transport [GO:0015718]; response to xenobiotic stimulus [GO:0009410]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P31647}; Multi-pass membrane protein {ECO:0000255}.
P48067	reviewed	SC6A9_HUMAN	Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9)	SLC6A9	Homo sapiens (Human)	706	FUNCTION: Sodium- and chloride-dependent glycine transporter (PubMed:8183239). Essential for regulating glycine concentrations at inhibitory glycinergic synapses. {ECO:0000250|UniProtKB:P28571, ECO:0000269|PubMed:8183239}.; FUNCTION: [Isoform GlyT-1B]: Sodium- and chloride-dependent glycine transporter. {ECO:0000269|PubMed:8183239}.; FUNCTION: [Isoform GlyT-1C]: Sodium- and chloride-dependent glycine transporter. {ECO:0000269|PubMed:8183239}.		glycine import across plasma membrane [GO:1903804]; glycine transport [GO:0015816]; negative regulation of NMDA glutamate receptor activity [GO:1904782]; neurotransmitter transport [GO:0006836]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; regulation of synaptic transmission, glycinergic [GO:0060092]; sodium ion transmembrane transport [GO:0035725]; synaptic transmission, glycinergic [GO:0060012]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; dense core granule [GO:0031045]; endosome [GO:0005768]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]	glycine transmembrane transporter activity [GO:0015187]; glycine:sodium symporter activity [GO:0015375]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; dense core granule [GO:0031045]; endosome [GO:0005768]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; glycine transmembrane transporter activity [GO:0015187]; glycine:sodium symporter activity [GO:0015375]; glycine import across plasma membrane [GO:1903804]; glycine transport [GO:0015816]; negative regulation of NMDA glutamate receptor activity [GO:1904782]; neurotransmitter transport [GO:0006836]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; regulation of synaptic transmission, glycinergic [GO:0060092]; sodium ion transmembrane transport [GO:0035725]; synaptic transmission, glycinergic [GO:0060012]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P28572}; Multi-pass membrane protein {ECO:0000255}.
P48145	reviewed	NPBW1_HUMAN	Neuropeptides B/W receptor type 1 (G-protein coupled receptor 7)	NPBWR1 GPR7	Homo sapiens (Human)	328	FUNCTION: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.		chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; regulation of metabolic process [GO:0019222]	membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled opioid receptor activity [GO:0004985]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]	membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled opioid receptor activity [GO:0004985]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; regulation of metabolic process [GO:0019222]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P48146	reviewed	NPBW2_HUMAN	Neuropeptides B/W receptor type 2 (G-protein coupled receptor 8)	NPBWR2 GPR8	Homo sapiens (Human)	333	FUNCTION: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.		G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	G protein-coupled opioid receptor activity [GO:0004985]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]	membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; G protein-coupled opioid receptor activity [GO:0004985]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P48147	reviewed	PPCE_HUMAN	Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme)	PREP PEP	Homo sapiens (Human)	710	FUNCTION: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.		proteolysis [GO:0006508]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	oligopeptidase activity [GO:0070012]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; oligopeptidase activity [GO:0070012]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm.
P48163	reviewed	MAOX_HUMAN	NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1)	ME1	Homo sapiens (Human)	572	FUNCTION: Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate. {ECO:0000269|PubMed:7622060, ECO:0000269|PubMed:7757881, ECO:0000269|PubMed:8187880, ECO:0000269|PubMed:8804575}.		carbohydrate metabolic process [GO:0005975]; malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; nucleotide biosynthetic process [GO:0009165]; protein homotetramerization [GO:0051289]; pyruvate metabolic process [GO:0006090]; regulation of NADP metabolic process [GO:1902031]; response to carbohydrate [GO:0009743]; response to hormone [GO:0009725]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	ADP binding [GO:0043531]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; malate dehydrogenase (decarboxylating) (NAD+) activity [GO:0004471]; malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; malic enzyme activity [GO:0004470]; manganese ion binding [GO:0030145]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; oxaloacetate decarboxylase activity [GO:0008948]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; ADP binding [GO:0043531]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; malate dehydrogenase (decarboxylating) (NAD+) activity [GO:0004471]; malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; malic enzyme activity [GO:0004470]; manganese ion binding [GO:0030145]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; oxaloacetate decarboxylase activity [GO:0008948]; carbohydrate metabolic process [GO:0005975]; malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; nucleotide biosynthetic process [GO:0009165]; protein homotetramerization [GO:0051289]; pyruvate metabolic process [GO:0006090]; regulation of NADP metabolic process [GO:1902031]; response to carbohydrate [GO:0009743]; response to hormone [GO:0009725]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8187880}.
P48165	reviewed	CXA8_HUMAN	Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70)	GJA8	Homo sapiens (Human)	433	FUNCTION: Structural component of eye lens gap junctions (PubMed:18006672, PubMed:19756179). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:18006672, PubMed:19756179). {ECO:0000250|UniProtKB:P55917, ECO:0000269|PubMed:16397066, ECO:0000269|PubMed:18006672, ECO:0000269|PubMed:19756179, ECO:0000269|PubMed:35531093}.		cell-cell signaling [GO:0007267]; gap junction-mediated intercellular transport [GO:1990349]; lens development in camera-type eye [GO:0002088]; regulation of granulocyte macrophage colony-stimulating factor production [GO:0032645]	connexin complex [GO:0005922]; plasma membrane [GO:0005886]	gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802]	connexin complex [GO:0005922]; plasma membrane [GO:0005886]; gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802]; cell-cell signaling [GO:0007267]; gap junction-mediated intercellular transport [GO:1990349]; lens development in camera-type eye [GO:0002088]; regulation of granulocyte macrophage colony-stimulating factor production [GO:0032645]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16397066, ECO:0000269|PubMed:18006672, ECO:0000269|PubMed:19756179, ECO:0000269|PubMed:26004348}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55917}. Cell junction, gap junction {ECO:0000269|PubMed:18006672, ECO:0000269|PubMed:19756179}.
P48167	reviewed	GLRB_HUMAN	Glycine receptor subunit beta (Glycine receptor 58 kDa subunit)	GLRB	Homo sapiens (Human)	497	FUNCTION: Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346, PubMed:34473954). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). {ECO:0000269|PubMed:11929858, ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:22715885, ECO:0000269|PubMed:23238346, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:34473954, ECO:0000269|PubMed:8717357}.		acrosome reaction [GO:0007340]; adult walking behavior [GO:0007628]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid receptor clustering [GO:0097112]; monoatomic ion transport [GO:0006811]; nervous system development [GO:0007399]; neuropeptide signaling pathway [GO:0007218]; righting reflex [GO:0060013]; startle response [GO:0001964]; synaptic transmission, glycinergic [GO:0060012]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; glycine-gated chloride channel complex [GO:0016935]; glycinergic synapse [GO:0098690]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]; synapse [GO:0045202]	extracellularly glycine-gated chloride channel activity [GO:0016934]; extracellularly glycine-gated ion channel activity [GO:0016933]; glycine binding [GO:0016594]; protein-containing complex binding [GO:0044877]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; glycine-gated chloride channel complex [GO:0016935]; glycinergic synapse [GO:0098690]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]; synapse [GO:0045202]; extracellularly glycine-gated chloride channel activity [GO:0016934]; extracellularly glycine-gated ion channel activity [GO:0016933]; glycine binding [GO:0016594]; protein-containing complex binding [GO:0044877]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; acrosome reaction [GO:0007340]; adult walking behavior [GO:0007628]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid receptor clustering [GO:0097112]; monoatomic ion transport [GO:0006811]; nervous system development [GO:0007399]; neuropeptide signaling pathway [GO:0007218]; righting reflex [GO:0060013]; startle response [GO:0001964]; synaptic transmission, glycinergic [GO:0060012]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P48168}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Synapse {ECO:0000250|UniProtKB:P48168}. Cell projection, dendrite {ECO:0000250|UniProtKB:P48168}. Cell membrane {ECO:0000269|PubMed:11929858, ECO:0000269|PubMed:12684523, ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:22715885, ECO:0000269|PubMed:22973015, ECO:0000269|PubMed:23238346, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:35526563, ECO:0000269|PubMed:8717357}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cytoplasm {ECO:0000269|PubMed:12684523, ECO:0000269|PubMed:35526563}. Note=Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane (PubMed:12684523). Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. {ECO:0000250|UniProtKB:P20781, ECO:0000269|PubMed:12684523}.
P48169	reviewed	GBRA4_HUMAN	Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4)	GABRA4	Homo sapiens (Human)	554	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.		chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]	benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
P48200	reviewed	IREB2_HUMAN	Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2)	IREB2	Homo sapiens (Human)	963	FUNCTION: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. {ECO:0000269|PubMed:7983023}.		citrate metabolic process [GO:0006101]; erythrocyte homeostasis [GO:0034101]; establishment of localization in cell [GO:0051649]; intestinal absorption [GO:0050892]; intracellular iron ion homeostasis [GO:0006879]; mRNA stabilization [GO:0048255]; multicellular organismal-level iron ion homeostasis [GO:0060586]; osteoclast differentiation [GO:0030316]; post-embryonic development [GO:0009791]; protoporphyrinogen IX biosynthetic process [GO:0006782]; regulation of translation [GO:0006417]; tricarboxylic acid cycle [GO:0006099]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; citrate metabolic process [GO:0006101]; erythrocyte homeostasis [GO:0034101]; establishment of localization in cell [GO:0051649]; intestinal absorption [GO:0050892]; intracellular iron ion homeostasis [GO:0006879]; mRNA stabilization [GO:0048255]; multicellular organismal-level iron ion homeostasis [GO:0060586]; osteoclast differentiation [GO:0030316]; post-embryonic development [GO:0009791]; protoporphyrinogen IX biosynthetic process [GO:0006782]; regulation of translation [GO:0006417]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Cytoplasm.
P48201	reviewed	AT5G3_HUMAN	ATP synthase F(0) complex subunit C3, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase membrane subunit c locus 3) (ATP synthase proteolipid P3) (ATP synthase proton-transporting mitochondrial F(0) complex subunit C3) (ATPase protein 9) (ATPase subunit c)	ATP5MC3 ATP5G3	Homo sapiens (Human)	142	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.	MISCELLANEOUS: There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).	proton motive force-driven ATP synthesis [GO:0015986]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]	lipid binding [GO:0008289]; proton transmembrane transporter activity [GO:0015078]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; lipid binding [GO:0008289]; proton transmembrane transporter activity [GO:0015078]; proton motive force-driven ATP synthesis [GO:0015986]	SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane protein.
P48230	reviewed	T4S4_HUMAN	Transmembrane 4 L6 family member 4 (Intestine and liver tetraspan membrane protein) (IL-TMP)	TM4SF4 ILTMP	Homo sapiens (Human)	202	FUNCTION: Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.		tissue regeneration [GO:0042246]	membrane [GO:0016020]		membrane [GO:0016020]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P48304	reviewed	REG1B_HUMAN	Lithostathine-1-beta (Pancreatic stone protein 2) (PSP-2) (Regenerating islet-derived protein 1-beta) (REG-1-beta) (Regenerating protein I beta)	REG1B PSPS2 REGL	Homo sapiens (Human)	166	FUNCTION: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell wall disruption in another organism [GO:0044278]; positive regulation of cell population proliferation [GO:0008284]; response to peptide hormone [GO:0043434]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	oligosaccharide binding [GO:0070492]; peptidoglycan binding [GO:0042834]; signaling receptor activity [GO:0038023]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; oligosaccharide binding [GO:0070492]; peptidoglycan binding [GO:0042834]; signaling receptor activity [GO:0038023]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell wall disruption in another organism [GO:0044278]; positive regulation of cell population proliferation [GO:0008284]; response to peptide hormone [GO:0043434]	SUBCELLULAR LOCATION: Secreted.
P48307	reviewed	TFPI2_HUMAN	Tissue factor pathway inhibitor 2 (TFPI-2) (Placental protein 5) (PP5)	TFPI2	Homo sapiens (Human)	235	FUNCTION: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. {ECO:0000269|PubMed:7872799}.		blood coagulation [GO:0007596]; cellular response to fluid shear stress [GO:0071498]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	extracellular matrix structural constituent [GO:0005201]; serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; serine-type endopeptidase inhibitor activity [GO:0004867]; blood coagulation [GO:0007596]; cellular response to fluid shear stress [GO:0071498]	SUBCELLULAR LOCATION: Secreted.
P48357	reviewed	LEPR_HUMAN	Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295)	LEPR DB OBR	Homo sapiens (Human)	1165	FUNCTION: Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity). {ECO:0000250|UniProtKB:P48356, ECO:0000269|PubMed:12504075, ECO:0000269|PubMed:22405007, ECO:0000269|PubMed:25060689, ECO:0000269|PubMed:8805376, ECO:0000269|PubMed:9537324, ECO:0000305|PubMed:25232147}.; FUNCTION: [Isoform A]: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3. {ECO:0000250|UniProtKB:P48356}.; FUNCTION: [Isoform E]: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis. {ECO:0000250|UniProtKB:P48356}.		angiogenesis [GO:0001525]; bone growth [GO:0098868]; cell surface receptor signaling pathway [GO:0007166]; cholesterol metabolic process [GO:0008203]; cytokine-mediated signaling pathway [GO:0019221]; energy homeostasis [GO:0097009]; energy reserve metabolic process [GO:0006112]; glial cell proliferation [GO:0014009]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glycogen metabolic process [GO:0005977]; leptin-mediated signaling pathway [GO:0033210]; multicellular organism development [GO:0007275]; negative regulation of autophagy [GO:0010507]; negative regulation of gluconeogenesis [GO:0045721]; phagocytosis [GO:0006909]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein phosphorylation [GO:0001934]; regulation of bone remodeling [GO:0046850]; regulation of feeding behavior [GO:0060259]; regulation of transport [GO:0051049]; response to leptin [GO:0044321]; sexual reproduction [GO:0019953]; T cell differentiation [GO:0030217]; transport across blood-brain barrier [GO:0150104]	basolateral plasma membrane [GO:0016323]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; leptin receptor activity [GO:0038021]; transmembrane signaling receptor activity [GO:0004888]	basolateral plasma membrane [GO:0016323]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; leptin receptor activity [GO:0038021]; transmembrane signaling receptor activity [GO:0004888]; angiogenesis [GO:0001525]; bone growth [GO:0098868]; cell surface receptor signaling pathway [GO:0007166]; cholesterol metabolic process [GO:0008203]; cytokine-mediated signaling pathway [GO:0019221]; energy homeostasis [GO:0097009]; energy reserve metabolic process [GO:0006112]; glial cell proliferation [GO:0014009]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glycogen metabolic process [GO:0005977]; leptin-mediated signaling pathway [GO:0033210]; multicellular organism development [GO:0007275]; negative regulation of autophagy [GO:0010507]; negative regulation of gluconeogenesis [GO:0045721]; phagocytosis [GO:0006909]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein phosphorylation [GO:0001934]; regulation of bone remodeling [GO:0046850]; regulation of feeding behavior [GO:0060259]; regulation of transport [GO:0051049]; response to leptin [GO:0044321]; sexual reproduction [GO:0019953]; T cell differentiation [GO:0030217]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19159218}; Single-pass type I membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:19159218}.; SUBCELLULAR LOCATION: [Isoform E]: Secreted {ECO:0000250|UniProtKB:P48356}.
P48378	reviewed	RFX2_HUMAN	DNA-binding protein RFX2 (Regulatory factor X 2)	RFX2	Homo sapiens (Human)	723	FUNCTION: Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis-specific histone gene H1-6 (By similarity). {ECO:0000250|UniProtKB:P48379, ECO:0000269|PubMed:10330134}.		acrosome assembly [GO:0001675]; cellular response to leukemia inhibitory factor [GO:1990830]; cilium assembly [GO:0060271]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; acrosome assembly [GO:0001675]; cellular response to leukemia inhibitory factor [GO:1990830]; cilium assembly [GO:0060271]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B2GV50, ECO:0000255|PROSITE-ProRule:PRU00858}. Cytoplasm {ECO:0000250|UniProtKB:B2GV50}. Note=Mainly expressed in the nucleus and at lower level in cytoplasm. {ECO:0000250|UniProtKB:B2GV50}.
P48380	reviewed	RFX3_HUMAN	Transcription factor RFX3 (Regulatory factor X 3)	RFX3	Homo sapiens (Human)	749	FUNCTION: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430). {ECO:0000250|UniProtKB:P48381, ECO:0000269|PubMed:12411430, ECO:0000269|PubMed:20148032}.		cell maturation [GO:0048469]; cilium assembly [GO:0060271]; cilium-dependent cell motility [GO:0060285]; DNA-templated transcription [GO:0006351]; endocrine pancreas development [GO:0031018]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell development [GO:2000078]; regulation of DNA-templated transcription [GO:0006355]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; type B pancreatic cell maturation [GO:0072560]	chromatin [GO:0000785]; extracellular region [GO:0005576]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; extracellular region [GO:0005576]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cell maturation [GO:0048469]; cilium assembly [GO:0060271]; cilium-dependent cell motility [GO:0060285]; DNA-templated transcription [GO:0006351]; endocrine pancreas development [GO:0031018]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell development [GO:2000078]; regulation of DNA-templated transcription [GO:0006355]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; type B pancreatic cell maturation [GO:0072560]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P48382	reviewed	RFX5_HUMAN	DNA-binding protein RFX5 (Regulatory factor X 5)	RFX5	Homo sapiens (Human)	616	FUNCTION: Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P48426	reviewed	PI42A_HUMAN	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)	PIP4K2A PI5P4KA PIP5K2 PIP5K2A	Homo sapiens (Human)	406	FUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:9367159, PubMed:23326584). Has both ATP- and GTP-dependent kinase activities (PubMed:26774281). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (PubMed:29353240). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439). PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000250|UniProtKB:O70172, ECO:0000250|UniProtKB:Q9R0I8, ECO:0000269|PubMed:18364242, ECO:0000269|PubMed:23326584, ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:29353240, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9367159}.		1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; autophagosome-lysosome fusion [GO:0061909]; megakaryocyte development [GO:0035855]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]; vesicle-mediated cholesterol transport [GO:0090119]	autophagosome [GO:0005776]; cytosol [GO:0005829]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]	1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]	autophagosome [GO:0005776]; cytosol [GO:0005829]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; autophagosome-lysosome fusion [GO:0061909]; megakaryocyte development [GO:0035855]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]; vesicle-mediated cholesterol transport [GO:0090119]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O70172}. Nucleus {ECO:0000269|PubMed:20583997}. Lysosome {ECO:0000250|UniProtKB:O70172}. Cytoplasm {ECO:0000269|PubMed:20583997}. Photoreceptor inner segment {ECO:0000250|UniProtKB:O70172}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:O70172}. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. {ECO:0000250|UniProtKB:O70172, ECO:0000269|PubMed:20583997}.
P48431	reviewed	SOX2_HUMAN	Transcription factor SOX-2	SOX2	Homo sapiens (Human)	317	FUNCTION: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). {ECO:0000250|UniProtKB:P48430, ECO:0000250|UniProtKB:P48432, ECO:0000269|PubMed:18035408}.		adenohypophysis development [GO:0021984]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; endodermal cell fate specification [GO:0001714]; eye development [GO:0001654]; forebrain development [GO:0030900]; glial cell fate commitment [GO:0021781]; inner ear development [GO:0048839]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuronal stem cell population maintenance [GO:0097150]; osteoblast differentiation [GO:0001649]; pituitary gland development [GO:0021983]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of myofibroblast cell apoptotic process [GO:1904520]; response to growth factor [GO:0070848]; response to oxygen-glucose deprivation [GO:0090649]; response to wounding [GO:0009611]; somatic stem cell population maintenance [GO:0035019]; tissue regeneration [GO:0042246]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; miRNA binding [GO:0035198]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; miRNA binding [GO:0035198]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; adenohypophysis development [GO:0021984]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; endodermal cell fate specification [GO:0001714]; eye development [GO:0001654]; forebrain development [GO:0030900]; glial cell fate commitment [GO:0021781]; inner ear development [GO:0048839]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuronal stem cell population maintenance [GO:0097150]; osteoblast differentiation [GO:0001649]; pituitary gland development [GO:0021983]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of myofibroblast cell apoptotic process [GO:1904520]; response to growth factor [GO:0070848]; response to oxygen-glucose deprivation [GO:0090649]; response to wounding [GO:0009611]; somatic stem cell population maintenance [GO:0035019]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q05066}. Cytoplasm {ECO:0000250|UniProtKB:Q05738}. Nucleus {ECO:0000250|UniProtKB:Q05738}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). {ECO:0000250|UniProtKB:Q05066, ECO:0000250|UniProtKB:Q05738}.
P48436	reviewed	SOX9_HUMAN	Transcription factor SOX-9	SOX9	Homo sapiens (Human)	509	FUNCTION: Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:24038782). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:8640233). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). {ECO:0000250|UniProtKB:Q04887, ECO:0000269|PubMed:24038782, ECO:0000269|PubMed:8640233}.		anterior head development [GO:0097065]; aortic valve morphogenesis [GO:0003180]; astrocyte fate commitment [GO:0060018]; bone mineralization [GO:0030282]; branching involved in ureteric bud morphogenesis [GO:0001658]; bronchus cartilage development [GO:0060532]; cAMP-mediated signaling [GO:0019933]; canonical Wnt signaling pathway [GO:0060070]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate specification [GO:0001708]; cell proliferation involved in heart morphogenesis [GO:0061323]; cell-cell adhesion [GO:0098609]; cellular response to BMP stimulus [GO:0071773]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to heparin [GO:0071504]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte differentiation [GO:0002062]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; chondrocyte hypertrophy [GO:0003415]; chromatin remodeling [GO:0006338]; cochlea morphogenesis [GO:0090103]; cytoskeleton organization [GO:0007010]; endocardial cushion morphogenesis [GO:0003203]; endocrine pancreas development [GO:0031018]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation involved in prostatic bud elongation [GO:0060517]; epithelial to mesenchymal transition [GO:0001837]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; ERK1 and ERK2 cascade [GO:0070371]; extracellular matrix assembly [GO:0085029]; glandular epithelial cell differentiation [GO:0002067]; glial cell fate specification [GO:0021780]; growth plate cartilage chondrocyte growth [GO:0003430]; hair follicle development [GO:0001942]; Harderian gland development [GO:0070384]; heart development [GO:0007507]; heart valve development [GO:0003170]; heart valve formation [GO:0003188]; heart valve morphogenesis [GO:0003179]; intestinal epithelial cell differentiation [GO:0060575]; intestinal epithelial structure maintenance [GO:0060729]; intrahepatic bile duct development [GO:0035622]; lacrimal gland development [GO:0032808]; limb bud formation [GO:0060174]; lung smooth muscle development [GO:0061145]; male germ-line sex determination [GO:0019100]; male gonad development [GO:0008584]; mammary gland development [GO:0030879]; mesenchymal cell apoptotic process [GO:0097152]; mesenchymal cell proliferation [GO:0010463]; metanephric nephron tubule formation [GO:0072289]; morphogenesis of a branching epithelium [GO:0061138]; morphogenesis of an epithelium [GO:0002009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of beta-catenin-TCF complex assembly [GO:1904864]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of bone mineralization [GO:0030502]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of gene expression [GO:0010629]; negative regulation of immune system process [GO:0002683]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; neural crest cell fate specification [GO:0014036]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; notochord development [GO:0030903]; nucleosome assembly [GO:0006334]; oligodendrocyte differentiation [GO:0048709]; otic vesicle formation [GO:0030916]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of gene expression [GO:0010628]; positive regulation of kidney development [GO:0090184]; positive regulation of male gonad development [GO:2000020]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; protein localization to nucleus [GO:0034504]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of branching involved in lung morphogenesis [GO:0061046]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle process [GO:0010564]; regulation of cell population proliferation [GO:0042127]; regulation of cell proliferation involved in tissue homeostasis [GO:0060784]; regulation of epithelial cell proliferation involved in lung morphogenesis [GO:2000794]; renal vesicle induction [GO:0072034]; response to fatty acid [GO:0070542]; response to organic cyclic compound [GO:0014070]; retina development in camera-type eye [GO:0060041]; retinal rod cell differentiation [GO:0060221]; Sertoli cell development [GO:0060009]; Sertoli cell differentiation [GO:0060008]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; somatic stem cell population maintenance [GO:0035019]; spermatogenesis [GO:0007283]; stem cell proliferation [GO:0072089]; tissue homeostasis [GO:0001894]; trachea cartilage development [GO:0060534]; transcription by RNA polymerase II [GO:0006366]; type I pneumocyte differentiation [GO:0060509]; ureter morphogenesis [GO:0072197]; ureter smooth muscle cell differentiation [GO:0072193]; ureter urothelium development [GO:0072190]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]	beta-catenin binding [GO:0008013]; bHLH transcription factor binding [GO:0043425]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; pre-mRNA intronic binding [GO:0097157]; protein kinase A catalytic subunit binding [GO:0034236]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]; beta-catenin binding [GO:0008013]; bHLH transcription factor binding [GO:0043425]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; pre-mRNA intronic binding [GO:0097157]; protein kinase A catalytic subunit binding [GO:0034236]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior head development [GO:0097065]; aortic valve morphogenesis [GO:0003180]; astrocyte fate commitment [GO:0060018]; bone mineralization [GO:0030282]; branching involved in ureteric bud morphogenesis [GO:0001658]; bronchus cartilage development [GO:0060532]; cAMP-mediated signaling [GO:0019933]; canonical Wnt signaling pathway [GO:0060070]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate specification [GO:0001708]; cell proliferation involved in heart morphogenesis [GO:0061323]; cell-cell adhesion [GO:0098609]; cellular response to BMP stimulus [GO:0071773]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to heparin [GO:0071504]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte differentiation [GO:0002062]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; chondrocyte hypertrophy [GO:0003415]; chromatin remodeling [GO:0006338]; cochlea morphogenesis [GO:0090103]; cytoskeleton organization [GO:0007010]; endocardial cushion morphogenesis [GO:0003203]; endocrine pancreas development [GO:0031018]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation involved in prostatic bud elongation [GO:0060517]; epithelial to mesenchymal transition [GO:0001837]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; ERK1 and ERK2 cascade [GO:0070371]; extracellular matrix assembly [GO:0085029]; glandular epithelial cell differentiation [GO:0002067]; glial cell fate specification [GO:0021780]; growth plate cartilage chondrocyte growth [GO:0003430]; hair follicle development [GO:0001942]; Harderian gland development [GO:0070384]; heart development [GO:0007507]; heart valve development [GO:0003170]; heart valve formation [GO:0003188]; heart valve morphogenesis [GO:0003179]; intestinal epithelial cell differentiation [GO:0060575]; intestinal epithelial structure maintenance [GO:0060729]; intrahepatic bile duct development [GO:0035622]; lacrimal gland development [GO:0032808]; limb bud formation [GO:0060174]; lung smooth muscle development [GO:0061145]; male germ-line sex determination [GO:0019100]; male gonad development [GO:0008584]; mammary gland development [GO:0030879]; mesenchymal cell apoptotic process [GO:0097152]; mesenchymal cell proliferation [GO:0010463]; metanephric nephron tubule formation [GO:0072289]; morphogenesis of a branching epithelium [GO:0061138]; morphogenesis of an epithelium [GO:0002009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of beta-catenin-TCF complex assembly [GO:1904864]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of bone mineralization [GO:0030502]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of gene expression [GO:0010629]; negative regulation of immune system process [GO:0002683]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; neural crest cell fate specification [GO:0014036]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; notochord development [GO:0030903]; nucleosome assembly [GO:0006334]; oligodendrocyte differentiation [GO:0048709]; otic vesicle formation [GO:0030916]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of gene expression [GO:0010628]; positive regulation of kidney development [GO:0090184]; positive regulation of male gonad development [GO:2000020]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; protein localization to nucleus [GO:0034504]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of branching involved in lung morphogenesis [GO:0061046]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle process [GO:0010564]; regulation of cell population proliferation [GO:0042127]; regulation of cell proliferation involved in tissue homeostasis [GO:0060784]; regulation of epithelial cell proliferation involved in lung morphogenesis [GO:2000794]; renal vesicle induction [GO:0072034]; response to fatty acid [GO:0070542]; response to organic cyclic compound [GO:0014070]; retina development in camera-type eye [GO:0060041]; retinal rod cell differentiation [GO:0060221]; Sertoli cell development [GO:0060009]; Sertoli cell differentiation [GO:0060008]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; somatic stem cell population maintenance [GO:0035019]; spermatogenesis [GO:0007283]; stem cell proliferation [GO:0072089]; tissue homeostasis [GO:0001894]; trachea cartilage development [GO:0060534]; transcription by RNA polymerase II [GO:0006366]; type I pneumocyte differentiation [GO:0060509]; ureter morphogenesis [GO:0072197]; ureter smooth muscle cell differentiation [GO:0072193]; ureter urothelium development [GO:0072190]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:8640233}.
P48443	reviewed	RXRG_HUMAN	Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma)	RXRG NR2B3	Homo sapiens (Human)	463	FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). {ECO:0000250}.		anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; molecular condensate scaffold activity [GO:0140693]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; retinoic acid-responsive element binding [GO:0044323]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; molecular condensate scaffold activity [GO:0140693]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; retinoic acid-responsive element binding [GO:0044323]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:28167758}. Cytoplasm {ECO:0000269|PubMed:28167758}.
P48444	reviewed	COPD_HUMAN	Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP)	ARCN1 COPD	Homo sapiens (Human)	511	FUNCTION: Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.		adult locomotory behavior [GO:0008344]; cerebellar Purkinje cell layer maturation [GO:0021691]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi localization [GO:0051645]; intracellular protein transport [GO:0006886]; pigmentation [GO:0043473]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133]	RNA binding [GO:0003723]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133]; RNA binding [GO:0003723]; adult locomotory behavior [GO:0008344]; cerebellar Purkinje cell layer maturation [GO:0021691]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi localization [GO:0051645]; intracellular protein transport [GO:0006886]; pigmentation [GO:0043473]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
P48448	reviewed	AL3B2_HUMAN	Aldehyde dehydrogenase family 3 member B2 (EC 1.2.1.3) (Aldehyde dehydrogenase 8)	ALDH3B2 ALDH8	Homo sapiens (Human)	385	FUNCTION: Oxidizes medium and long chain aldehydes into non-toxic fatty acids. {ECO:0000250|UniProtKB:E9Q3E1}.		alcohol metabolic process [GO:0006066]; cellular aldehyde metabolic process [GO:0006081]; ethanol catabolic process [GO:0006068]; lipid metabolic process [GO:0006629]; sphingolipid biosynthetic process [GO:0030148]	cytoplasm [GO:0005737]; lipid droplet [GO:0005811]	3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]	cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; alcohol metabolic process [GO:0006066]; cellular aldehyde metabolic process [GO:0006081]; ethanol catabolic process [GO:0006068]; lipid metabolic process [GO:0006629]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Lipid droplet {ECO:0000250|UniProtKB:E9Q3E1}.
P48449	reviewed	LSS_HUMAN	Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC)	LSS OSC	Homo sapiens (Human)	732	FUNCTION: Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:14766201, PubMed:7639730, PubMed:26200341). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (PubMed:26200341). {ECO:0000269|PubMed:14766201, ECO:0000269|PubMed:26200341, ECO:0000269|PubMed:7639730}.		cholesterol biosynthetic process [GO:0006695]; regulation of protein stability [GO:0031647]; steroid biosynthetic process [GO:0006694]; triterpenoid biosynthetic process [GO:0016104]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]	lanosterol synthase activity [GO:0000250]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]; lanosterol synthase activity [GO:0000250]; cholesterol biosynthetic process [GO:0006695]; regulation of protein stability [GO:0031647]; steroid biosynthetic process [GO:0006694]; triterpenoid biosynthetic process [GO:0016104]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14766201, ECO:0000269|PubMed:15525992, ECO:0000269|PubMed:30401459}; Peripheral membrane protein {ECO:0000269|PubMed:14766201, ECO:0000269|PubMed:15525992}.
P48454	reviewed	PP2BC_HUMAN	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform)	PPP3CC CALNA3 CNA3	Homo sapiens (Human)	512	FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. {ECO:0000269|PubMed:19154138}.		calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; protein dephosphorylation [GO:0006470]	calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; presynapse [GO:0098793]; protein serine/threonine phosphatase complex [GO:0008287]	calcium-dependent protein serine/threonine phosphatase activity [GO:0004723]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]	calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; presynapse [GO:0098793]; protein serine/threonine phosphatase complex [GO:0008287]; calcium-dependent protein serine/threonine phosphatase activity [GO:0004723]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P48455}. Note=Localizes in the mitochondria in a SPATA33-dependent manner. {ECO:0000250|UniProtKB:P48455}.
P48506	reviewed	GSH1_HUMAN	Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase)	GCLC GLCL GLCLC	Homo sapiens (Human)	637	FUNCTION: Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis. {ECO:0000269|PubMed:9675072}.		blood vessel diameter maintenance [GO:0097746]; cell redox homeostasis [GO:0045454]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to insulin stimulus [GO:0032869]; cellular response to mechanical stimulus [GO:0071260]; cellular response to thyroxine stimulus [GO:0097069]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of hepatic stellate cell activation [GO:2000490]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to arsenic-containing substance [GO:0046685]; response to cadmium ion [GO:0046686]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to human chorionic gonadotropin [GO:0044752]; response to interleukin-1 [GO:0070555]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]	cytosol [GO:0005829]; glutamate-cysteine ligase complex [GO:0017109]; mitochondrion [GO:0005739]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; glutamate binding [GO:0016595]; glutamate-cysteine ligase activity [GO:0004357]; magnesium ion binding [GO:0000287]; protein-containing complex binding [GO:0044877]	cytosol [GO:0005829]; glutamate-cysteine ligase complex [GO:0017109]; mitochondrion [GO:0005739]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; glutamate binding [GO:0016595]; glutamate-cysteine ligase activity [GO:0004357]; magnesium ion binding [GO:0000287]; protein-containing complex binding [GO:0044877]; blood vessel diameter maintenance [GO:0097746]; cell redox homeostasis [GO:0045454]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to insulin stimulus [GO:0032869]; cellular response to mechanical stimulus [GO:0071260]; cellular response to thyroxine stimulus [GO:0097069]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of hepatic stellate cell activation [GO:2000490]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to arsenic-containing substance [GO:0046685]; response to cadmium ion [GO:0046686]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to human chorionic gonadotropin [GO:0044752]; response to interleukin-1 [GO:0070555]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]	
P48507	reviewed	GSH0_HUMAN	Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit)	GCLM GLCLR	Homo sapiens (Human)	274			apoptotic mitochondrial changes [GO:0008637]; blood vessel diameter maintenance [GO:0097746]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to thyroxine stimulus [GO:0097069]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; hepatic stellate cell activation [GO:0035733]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to human chorionic gonadotropin [GO:0044752]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]	cytosol [GO:0005829]; glutamate-cysteine ligase complex [GO:0017109]	enzyme regulator activity [GO:0030234]; glutamate-cysteine ligase activity [GO:0004357]; glutamate-cysteine ligase catalytic subunit binding [GO:0035226]; protein-containing complex binding [GO:0044877]	cytosol [GO:0005829]; glutamate-cysteine ligase complex [GO:0017109]; enzyme regulator activity [GO:0030234]; glutamate-cysteine ligase activity [GO:0004357]; glutamate-cysteine ligase catalytic subunit binding [GO:0035226]; protein-containing complex binding [GO:0044877]; apoptotic mitochondrial changes [GO:0008637]; blood vessel diameter maintenance [GO:0097746]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to thyroxine stimulus [GO:0097069]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; hepatic stellate cell activation [GO:0035733]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to human chorionic gonadotropin [GO:0044752]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]	
P48509	reviewed	CD151_HUMAN	CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151)	CD151 TSPAN24	Homo sapiens (Human)	253	FUNCTION: Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. {ECO:0000269|PubMed:15265795}.; FUNCTION: (Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor. {ECO:0000269|PubMed:24553111}.		cell adhesion [GO:0007155]; cell migration [GO:0016477]; positive regulation of cell migration [GO:0030335]; positive regulation of endocytosis [GO:0045807]; T cell proliferation [GO:0042098]; wound healing, spreading of cells [GO:0044319]	basement membrane [GO:0005604]; cell surface [GO:0009986]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]	basement membrane [GO:0005604]; cell surface [GO:0009986]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; positive regulation of cell migration [GO:0030335]; positive regulation of endocytosis [GO:0045807]; T cell proliferation [GO:0042098]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P48539	reviewed	PCP4_HUMAN	Calmodulin regulator protein PCP4 (Brain-specific polypeptide PEP-19) (Purkinje cell protein 4)	PCP4 PEP19	Homo sapiens (Human)	62	FUNCTION: Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls (PubMed:19106096, PubMed:23204517, PubMed:27876793). For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways (PubMed:21491429). {ECO:0000269|PubMed:19106096, ECO:0000269|PubMed:21491429, ECO:0000269|PubMed:23204517, ECO:0000269|PubMed:27876793}.		calmodulin dependent kinase signaling pathway [GO:0099004]; positive regulation of neuron differentiation [GO:0045666]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin dependent kinase signaling pathway [GO:0099004]; positive regulation of neuron differentiation [GO:0045666]	
P48544	reviewed	KCNJ5_HUMAN	G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)	KCNJ5 GIRK4	Homo sapiens (Human)	419	FUNCTION: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. {ECO:0000269|PubMed:22315453, ECO:0000269|PubMed:22628607, ECO:0000269|PubMed:24037882, ECO:0000269|PubMed:27099398, ECO:0000269|PubMed:27293068}.		membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of monoatomic ion transmembrane transport [GO:0034765]; ventricular cardiac muscle cell membrane repolarization [GO:0099625]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; G-protein activated inward rectifier potassium channel activity [GO:0015467]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]; membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of monoatomic ion transmembrane transport [GO:0034765]; ventricular cardiac muscle cell membrane repolarization [GO:0099625]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:22315453, ECO:0000269|PubMed:24037882}; Multi-pass membrane protein {ECO:0000255}.
P48546	reviewed	GIPR_HUMAN	Gastric inhibitory polypeptide receptor (GIP-R) (Glucose-dependent insulinotropic polypeptide receptor)	GIPR	Homo sapiens (Human)	466	FUNCTION: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.		activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; endocrine pancreas development [GO:0031018]; gastric inhibitory peptide signaling pathway [GO:0038192]; generation of precursor metabolites and energy [GO:0006091]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of insulin secretion [GO:0032024]; regulation of insulin secretion [GO:0050796]; response to axon injury [GO:0048678]; response to calcium ion [GO:0051592]; response to fatty acid [GO:0070542]; response to glucose [GO:0009749]; response to nutrient [GO:0007584]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; gastric inhibitory peptide receptor activity [GO:0016519]; glucagon family peptide binding [GO:0120022]; peptide hormone binding [GO:0017046]; transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; gastric inhibitory peptide receptor activity [GO:0016519]; glucagon family peptide binding [GO:0120022]; peptide hormone binding [GO:0017046]; transmembrane signaling receptor activity [GO:0004888]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; endocrine pancreas development [GO:0031018]; gastric inhibitory peptide signaling pathway [GO:0038192]; generation of precursor metabolites and energy [GO:0006091]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of insulin secretion [GO:0032024]; regulation of insulin secretion [GO:0050796]; response to axon injury [GO:0048678]; response to calcium ion [GO:0051592]; response to fatty acid [GO:0070542]; response to glucose [GO:0009749]; response to nutrient [GO:0007584]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P48547	reviewed	KCNC1_HUMAN	Potassium voltage-gated channel subfamily C member 1 (NGK2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)	KCNC1	Homo sapiens (Human)	511	FUNCTION: Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:25401298). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. {ECO:0000250|UniProtKB:P25122, ECO:0000269|PubMed:25401298}.		cellular response to xenobiotic stimulus [GO:0071466]; cerebellum development [GO:0021549]; corpus callosum development [GO:0022038]; globus pallidus development [GO:0021759]; optic nerve development [GO:0021554]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein tetramerization [GO:0051262]; response to amine [GO:0014075]; response to auditory stimulus [GO:0010996]; response to fibroblast growth factor [GO:0071774]; response to light intensity [GO:0009642]; response to nerve growth factor [GO:1990089]; response to potassium ion [GO:0035864]; response to toxic substance [GO:0009636]	axolemma [GO:0030673]; axon terminus [GO:0043679]; calyx of Held [GO:0044305]; cell surface [GO:0009986]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; kinesin binding [GO:0019894]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]	axolemma [GO:0030673]; axon terminus [GO:0043679]; calyx of Held [GO:0044305]; cell surface [GO:0009986]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; kinesin binding [GO:0019894]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]; cellular response to xenobiotic stimulus [GO:0071466]; cerebellum development [GO:0021549]; corpus callosum development [GO:0022038]; globus pallidus development [GO:0021759]; optic nerve development [GO:0021554]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein tetramerization [GO:0051262]; response to amine [GO:0014075]; response to auditory stimulus [GO:0010996]; response to fibroblast growth factor [GO:0071774]; response to light intensity [GO:0009642]; response to nerve growth factor [GO:1990089]; response to potassium ion [GO:0035864]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25401298}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P25122}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P25122}. Note=Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones. {ECO:0000250|UniProtKB:P25122}.
P48549	reviewed	KCNJ3_HUMAN	G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3)	KCNJ3 GIRK1	Homo sapiens (Human)	501	FUNCTION: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.		membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to electrical stimulus [GO:0051602]; ventricular cardiac muscle cell membrane repolarization [GO:0099625]	external side of plasma membrane [GO:0009897]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]	external side of plasma membrane [GO:0009897]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]; G-protein activated inward rectifier potassium channel activity [GO:0015467]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]; membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to electrical stimulus [GO:0051602]; ventricular cardiac muscle cell membrane repolarization [GO:0099625]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P48551	reviewed	INAR2_HUMAN	Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)	IFNAR2 IFNABR IFNARB	Homo sapiens (Human)	515	FUNCTION: Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:8181059, PubMed:7665574, PubMed:7759950, PubMed:8798579, PubMed:8969169, PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:8181059, PubMed:7665574, PubMed:7759950, PubMed:8798579, PubMed:8969169, PubMed:10049744, PubMed:17517919, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:10556041, PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT) (PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:9121453, PubMed:12105218, PubMed:28165510). {ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:10556041, ECO:0000269|PubMed:11682488, ECO:0000269|PubMed:12105218, ECO:0000269|PubMed:17517919, ECO:0000269|PubMed:21854986, ECO:0000269|PubMed:26424569, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059, ECO:0000269|PubMed:8798579, ECO:0000269|PubMed:8969169, ECO:0000269|PubMed:9121453}.; FUNCTION: [Isoform 3]: Potent inhibitor of type I IFN receptor activity. {ECO:0000269|PubMed:7759950}.	MISCELLANEOUS: [Isoform 3]: Soluble receptor. {ECO:0000305}.	cell surface receptor signaling pathway [GO:0007166]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cytokine binding [GO:0019955]; interleukin-22 receptor activity [GO:0042018]; JAK pathway signal transduction adaptor activity [GO:0008269]; protein kinase binding [GO:0019901]; type I interferon binding [GO:0019962]; type I interferon receptor activity [GO:0004905]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cytokine binding [GO:0019955]; interleukin-22 receptor activity [GO:0042018]; JAK pathway signal transduction adaptor activity [GO:0008269]; protein kinase binding [GO:0019901]; type I interferon binding [GO:0019962]; type I interferon receptor activity [GO:0004905]; cell surface receptor signaling pathway [GO:0007166]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:7665574}; Single-pass type I membrane protein {ECO:0000269|PubMed:7665574}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059}; Single-pass type I membrane protein {ECO:0000269|PubMed:7665574}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059}.
P48552	reviewed	NRIP1_HUMAN	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140)	NRIP1	Homo sapiens (Human)	1158	FUNCTION: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}.		cellular response to estradiol stimulus [GO:0071392]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; lipid storage [GO:0019915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ovarian follicle rupture [GO:0001543]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; histone deacetylase complex [GO:0000118]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone deacetylase binding [GO:0042826]; nuclear estrogen receptor binding [GO:0030331]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor binding [GO:0016922]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; histone deacetylase complex [GO:0000118]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone deacetylase binding [GO:0042826]; nuclear estrogen receptor binding [GO:0030331]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor binding [GO:0016922]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; cellular response to estradiol stimulus [GO:0071392]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; lipid storage [GO:0019915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ovarian follicle rupture [GO:0001543]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11266503, ECO:0000269|PubMed:12773562, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:7641693}. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.
P48553	reviewed	TPC10_HUMAN	Trafficking protein particle complex subunit 10 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (Protein GT334) (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1)	TRAPPC10 EHOC1 TMEM1	Homo sapiens (Human)	1259	FUNCTION: Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether. {ECO:0000269|PubMed:11805826, ECO:0000269|PubMed:31467083, ECO:0000269|PubMed:35298461}.		early endosome to Golgi transport [GO:0034498]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; early endosome to Golgi transport [GO:0034498]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
P48556	reviewed	PSMD8_HUMAN	26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14) (p31)	PSMD8	Homo sapiens (Human)	350	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	
P48594	reviewed	SPB4_HUMAN	Serpin B4 (Leupin) (Peptidase inhibitor 11) (PI-11) (Squamous cell carcinoma antigen 2) (SCCA-2)	SERPINB4 PI11 SCCA2	Homo sapiens (Human)	390	FUNCTION: May act as a protease inhibitor to modulate the host immune response against tumor cells.		negative regulation of peptidase activity [GO:0010466]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; regulation of proteolysis [GO:0030162]	cytosol [GO:0005829]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]	cytosol [GO:0005829]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of peptidase activity [GO:0010466]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; regulation of proteolysis [GO:0030162]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10956412}. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
P48595	reviewed	SPB10_HUMAN	Serpin B10 (Bomapin) (Peptidase inhibitor 10) (PI-10)	SERPINB10 PI10	Homo sapiens (Human)	397	FUNCTION: Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10871600, ECO:0000269|PubMed:7592909}.			cytosol [GO:0005829]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	serine-type endopeptidase inhibitor activity [GO:0004867]	cytosol [GO:0005829]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Mostly found in the nucleus.
P48634	reviewed	PRC2A_HUMAN	Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2)	PRRC2A BAT2 G2	Homo sapiens (Human)	2157	FUNCTION: May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.		cell differentiation [GO:0030154]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	RNA binding [GO:0003723]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]; cell differentiation [GO:0030154]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15752841}. Nucleus {ECO:0000269|PubMed:15752841}.
P48637	reviewed	GSHB_HUMAN	Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase)	GSS	Homo sapiens (Human)	474	FUNCTION: Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51855, ECO:0000269|PubMed:7646467, ECO:0000269|PubMed:9215686, ECO:0000303|PubMed:10369661}.	MISCELLANEOUS: [Isoform 2]: Detected in colon, kidney, lung, liver, placenta, peripheral blood and uterus, but not in heart, skeletal muscle and spleen. {ECO:0000305}.	amino acid metabolic process [GO:0006520]; nervous system development [GO:0007399]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	ATP binding [GO:0005524]; glutathione binding [GO:0043295]; glutathione synthase activity [GO:0004363]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; glutathione binding [GO:0043295]; glutathione synthase activity [GO:0004363]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; amino acid metabolic process [GO:0006520]; nervous system development [GO:0007399]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979]	
P48643	reviewed	TCPE_HUMAN	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon)	CCT5 CCTE KIAA0098	Homo sapiens (Human)	541	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.		binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to virus [GO:0009615]	cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; beta-tubulin binding [GO:0048487]; G-protein beta-subunit binding [GO:0031681]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]	cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; beta-tubulin binding [GO:0048487]; G-protein beta-subunit binding [GO:0031681]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]; binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20080638}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20080638}.
P48645	reviewed	NMU_HUMAN	Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36 (NURP36); Neuromedin precursor-related peptide 33 (NURP33); Neuromedin-U-25 (NmU-25)]	NMU	Homo sapiens (Human)	174	FUNCTION: [Neuromedin-U-25]: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. {ECO:0000250|UniProtKB:P12760}.; FUNCTION: [Neuromedin precursor-related peptide 33]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. {ECO:0000250|UniProtKB:P12760}.; FUNCTION: [Neuromedin precursor-related peptide 36]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. {ECO:0000250|UniProtKB:P12760}.		energy homeostasis [GO:0097009]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of synaptic transmission [GO:0050806]; regulation of feeding behavior [GO:0060259]; regulation of grooming behavior [GO:2000821]; temperature homeostasis [GO:0001659]	extracellular region [GO:0005576]; terminal bouton [GO:0043195]	neuromedin U receptor binding [GO:0042922]; signaling receptor binding [GO:0005102]; type 1 neuromedin U receptor binding [GO:0031839]; type 2 neuromedin U receptor binding [GO:0031840]	extracellular region [GO:0005576]; terminal bouton [GO:0043195]; neuromedin U receptor binding [GO:0042922]; signaling receptor binding [GO:0005102]; type 1 neuromedin U receptor binding [GO:0031839]; type 2 neuromedin U receptor binding [GO:0031840]; energy homeostasis [GO:0097009]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of synaptic transmission [GO:0050806]; regulation of feeding behavior [GO:0060259]; regulation of grooming behavior [GO:2000821]; temperature homeostasis [GO:0001659]	SUBCELLULAR LOCATION: Secreted.
P48651	reviewed	PTSS1_HUMAN	Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I)	PTDSS1 KIAA0024 PSSA	Homo sapiens (Human)	473	FUNCTION: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:19014349, PubMed:24241535). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:19014349, PubMed:24241535). {ECO:0000269|PubMed:19014349, ECO:0000269|PubMed:24241535}.		phosphatidylserine biosynthetic process [GO:0006659]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	L-serine-phosphatidylcholine phosphatidyltransferase activity [GO:0106258]; L-serine-phosphatidylethanolamine phosphatidyltransferase activity [GO:0106245]; transferase activity [GO:0016740]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; L-serine-phosphatidylcholine phosphatidyltransferase activity [GO:0106258]; L-serine-phosphatidylethanolamine phosphatidyltransferase activity [GO:0106245]; transferase activity [GO:0016740]; phosphatidylserine biosynthetic process [GO:0006659]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q99LH2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q99LH2}. Note=Highly enriched in the mitochondria-associated membrane (MAM). {ECO:0000250|UniProtKB:Q99LH2}.
P48664	reviewed	EAA4_HUMAN	Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6)	SLC1A6 EAAT4	Homo sapiens (Human)	564	FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:7791878). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable). {ECO:0000250|UniProtKB:O35921, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7791878}.		aspartate transmembrane transport [GO:0015810]; chemical synaptic transmission [GO:0007268]; establishment of localization in cell [GO:0051649]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; regulation of membrane potential [GO:0042391]	glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; membrane protein complex [GO:0098796]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; membrane protein complex [GO:0098796]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; aspartate transmembrane transport [GO:0015810]; chemical synaptic transmission [GO:0007268]; establishment of localization in cell [GO:0051649]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; regulation of membrane potential [GO:0042391]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7791878}; Multi-pass membrane protein {ECO:0000305}.
P48668	reviewed	K2C6C_HUMAN	Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12)	KRT6C KRT6E	Homo sapiens (Human)	564		MISCELLANEOUS: There are at least six isoforms of human type II keratin-6 (K6).; MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
P48681	reviewed	NEST_HUMAN	Nestin	NES Nbla00170	Homo sapiens (Human)	1621	FUNCTION: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.		brain development [GO:0007420]; cell projection morphogenesis [GO:0048858]; central nervous system development [GO:0007417]; embryonic camera-type eye development [GO:0031076]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of catalytic activity [GO:0043086]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein binding [GO:0032091]; neuron apoptotic process [GO:0051402]; positive regulation of intermediate filament depolymerization [GO:0030844]; positive regulation of neural precursor cell proliferation [GO:2000179]; stem cell proliferation [GO:0072089]	cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]	CCR5 chemokine receptor binding [GO:0031730]; intermediate filament binding [GO:0019215]	cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; CCR5 chemokine receptor binding [GO:0031730]; intermediate filament binding [GO:0019215]; brain development [GO:0007420]; cell projection morphogenesis [GO:0048858]; central nervous system development [GO:0007417]; embryonic camera-type eye development [GO:0031076]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of catalytic activity [GO:0043086]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein binding [GO:0032091]; neuron apoptotic process [GO:0051402]; positive regulation of intermediate filament depolymerization [GO:0030844]; positive regulation of neural precursor cell proliferation [GO:2000179]; stem cell proliferation [GO:0072089]	
P48723	reviewed	HSP13_HUMAN	Heat shock 70 kDa protein 13 (Microsomal stress-70 protein ATPase core) (Stress-70 protein chaperone microsome-associated 60 kDa protein)	HSPA13 STCH	Homo sapiens (Human)	471	FUNCTION: Has peptide-independent ATPase activity.		chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026]	SUBCELLULAR LOCATION: Microsome. Endoplasmic reticulum.
P48728	reviewed	GCST_HUMAN	Aminomethyltransferase, mitochondrial (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT)	AMT GCST	Homo sapiens (Human)	403	FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. {ECO:0000269|PubMed:16051266}.		glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	aminomethyltransferase activity [GO:0004047]; transaminase activity [GO:0008483]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; aminomethyltransferase activity [GO:0004047]; transaminase activity [GO:0008483]; glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:16051266}.
P48729	reviewed	KC1A_HUMAN	Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1)	CSNK1A1	Homo sapiens (Human)	337	FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:18305108, PubMed:11955436, PubMed:1409656, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:18305108, PubMed:11955436, PubMed:1409656, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:23902688}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cell surface receptor signaling pathway [GO:0007166]; cellular response to nutrient [GO:0031670]; Golgi organization [GO:0007030]; intermediate filament cytoskeleton organization [GO:0045104]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of TORC1 signaling [GO:1904263]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein phosphorylation [GO:0006468]; regulation of GTP binding [GO:1904424]; signal transduction [GO:0007165]; viral protein processing [GO:0019082]; Wnt signaling pathway [GO:0016055]	beta-catenin destruction complex [GO:0030877]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spindle [GO:0005819]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	beta-catenin destruction complex [GO:0030877]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spindle [GO:0005819]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell surface receptor signaling pathway [GO:0007166]; cellular response to nutrient [GO:0031670]; Golgi organization [GO:0007030]; intermediate filament cytoskeleton organization [GO:0045104]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of TORC1 signaling [GO:1904263]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein phosphorylation [GO:0006468]; regulation of GTP binding [GO:1904424]; signal transduction [GO:0007165]; viral protein processing [GO:0019082]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1409656}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:1409656}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:1409656}. Nucleus speckle {ECO:0000303|PubMed:18305108}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8BK63}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8BK63}. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688). {ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:23902688}.
P48730	reviewed	KC1D_HUMAN	Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)	CSNK1D HCKID	Homo sapiens (Human)	415	FUNCTION: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}.	MISCELLANEOUS: May be involved in Alzheimer disease by phosphorylating MAPT/TAU. {ECO:0000305|PubMed:17562708}.	cellular response to nerve growth factor stimulus [GO:1990090]; circadian regulation of gene expression [GO:0032922]; COPII vesicle coating [GO:0048208]; endocytosis [GO:0006897]; Golgi organization [GO:0007030]; microtubule nucleation [GO:0007020]; non-motile cilium assembly [GO:1905515]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation [GO:1905426]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; protein localization to Golgi apparatus [GO:0034067]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; signal transduction [GO:0007165]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle microtubule [GO:0005876]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]; cellular response to nerve growth factor stimulus [GO:1990090]; circadian regulation of gene expression [GO:0032922]; COPII vesicle coating [GO:0048208]; endocytosis [GO:0006897]; Golgi organization [GO:0007030]; microtubule nucleation [GO:0007020]; non-motile cilium assembly [GO:1905515]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation [GO:1905426]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; protein localization to Golgi apparatus [GO:0034067]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; signal transduction [GO:0007165]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity.
P48735	reviewed	IDHP_HUMAN	Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)	IDH2	Homo sapiens (Human)	452	FUNCTION: Plays a role in intermediary metabolism and energy production (PubMed:22416140, PubMed:19228619). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:22416140, PubMed:19228619). {ECO:0000269|PubMed:19228619, ECO:0000269|PubMed:22416140}.		2-oxoglutarate metabolic process [GO:0006103]; carbohydrate metabolic process [GO:0005975]; glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; NADP metabolic process [GO:0006739]; tricarboxylic acid cycle [GO:0006099]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]	isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]; isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; 2-oxoglutarate metabolic process [GO:0006103]; carbohydrate metabolic process [GO:0005975]; glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; NADP metabolic process [GO:0006739]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P33198}.
P48736	reviewed	PK3CG_HUMAN	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)	PIK3CG	Homo sapiens (Human)	1102	FUNCTION: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation, activation, and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. {ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12163475, ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:15294162, ECO:0000269|PubMed:16094730, ECO:0000269|PubMed:16123124, ECO:0000269|PubMed:21393242, ECO:0000269|PubMed:31554793, ECO:0000269|PubMed:33054089, ECO:0000269|PubMed:7624799}.	MISCELLANEOUS: Candidate target in therapy for inflammatory diseases. Selective inhibitors and protein ablation are anti-inflammatory in multiple disease models such as asthma, rheumatoid arthritis, allergy, systemic lupus erythematosus, airway inflammation, lung injury and pancreatitis (PubMed:18278175). {ECO:0000305|PubMed:18278175}.	adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; cellular response to cAMP [GO:0071320]; dendritic cell chemotaxis [GO:0002407]; endocytosis [GO:0006897]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatocyte apoptotic process [GO:0097284]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mast cell degranulation [GO:0043303]; natural killer cell chemotaxis [GO:0035747]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of triglyceride catabolic process [GO:0010897]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; platelet aggregation [GO:0070527]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of Rac protein signal transduction [GO:0035022]; regulation of angiogenesis [GO:0045765]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cell adhesion mediated by integrin [GO:0033628]; respiratory burst involved in defense response [GO:0002679]; secretory granule localization [GO:0032252]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell proliferation [GO:0042098]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; ephrin receptor binding [GO:0046875]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; ephrin receptor binding [GO:0046875]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; cellular response to cAMP [GO:0071320]; dendritic cell chemotaxis [GO:0002407]; endocytosis [GO:0006897]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatocyte apoptotic process [GO:0097284]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mast cell degranulation [GO:0043303]; natural killer cell chemotaxis [GO:0035747]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of triglyceride catabolic process [GO:0010897]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; platelet aggregation [GO:0070527]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of Rac protein signal transduction [GO:0035022]; regulation of angiogenesis [GO:0045765]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cell adhesion mediated by integrin [GO:0033628]; respiratory burst involved in defense response [GO:0002679]; secretory granule localization [GO:0032252]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12163475}. Cell membrane {ECO:0000269|PubMed:12163475}.
P48739	reviewed	PIPNB_HUMAN	Phosphatidylinositol transfer protein beta isoform (PI-TP-beta) (PtdIns transfer protein beta) (PtdInsTP beta)	PITPNB	Homo sapiens (Human)	271	FUNCTION: Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed:10531358, PubMed:18636990, PubMed:20332109). Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed:20332109). {ECO:0000250|UniProtKB:Q9TR36, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:18636990, ECO:0000269|PubMed:20332109}.		lipid metabolic process [GO:0006629]; nucleus organization [GO:0006997]; phospholipid transport [GO:0015914]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; sphingomyelin transfer activity [GO:0140338]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; sphingomyelin transfer activity [GO:0140338]; lipid metabolic process [GO:0006629]; nucleus organization [GO:0006997]; phospholipid transport [GO:0015914]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:P53811}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P53812}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P53812}.
P48740	reviewed	MASP1_HUMAN	Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]	MASP1 CRARF CRARF1 PRSS5	Homo sapiens (Human)	699	FUNCTION: Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343). {ECO:0000269|PubMed:11485744, ECO:0000269|PubMed:21258343}.		complement activation, lectin pathway [GO:0001867]; negative regulation of complement activation [GO:0045916]; zymogen activation [GO:0031638]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]; complement activation, lectin pathway [GO:0001867]; negative regulation of complement activation [GO:0045916]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11485744}.
P48742	reviewed	LHX1_HUMAN	LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1) (hLim-1)	LHX1 LIM-1 LIM1	Homo sapiens (Human)	406	FUNCTION: Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. {ECO:0000269|PubMed:9212161}.		anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; anterior/posterior pattern specification [GO:0009952]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell signaling [GO:0007267]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [GO:0021937]; cerebellum development [GO:0021549]; cervix development [GO:0060067]; comma-shaped body morphogenesis [GO:0072049]; dorsal spinal cord interneuron posterior axon guidance [GO:0097379]; dorsal/ventral pattern formation [GO:0009953]; ectoderm formation [GO:0001705]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; embryonic viscerocranium morphogenesis [GO:0048703]; endoderm formation [GO:0001706]; epithelium development [GO:0060429]; forebrain regionalization [GO:0021871]; gastrulation with mouth forming second [GO:0001702]; head development [GO:0060322]; kidney development [GO:0001822]; lateral motor column neuron migration [GO:0097477]; mesendoderm development [GO:0048382]; mesonephric duct development [GO:0072177]; metanephric comma-shaped body morphogenesis [GO:0072278]; metanephric glomerulus development [GO:0072224]; metanephric part of ureteric bud development [GO:0035502]; metanephric renal vesicle morphogenesis [GO:0072283]; metanephric S-shaped body morphogenesis [GO:0072284]; motor neuron axon guidance [GO:0008045]; negative regulation of DNA-templated transcription [GO:0045892]; nephric duct elongation [GO:0035849]; nephric duct morphogenesis [GO:0072178]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; oviduct development [GO:0060066]; oviduct epithelium development [GO:0035846]; paramesonephric duct development [GO:0061205]; pattern specification process [GO:0007389]; positive regulation of anterior head development [GO:2000744]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; post-embryonic development [GO:0009791]; primitive streak formation [GO:0090009]; pronephros development [GO:0048793]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; renal vesicle morphogenesis [GO:0072077]; retina layer formation [GO:0010842]; S-shaped body morphogenesis [GO:0072050]; somite rostral/caudal axis specification [GO:0032525]; spinal cord association neuron differentiation [GO:0021527]; telencephalon development [GO:0021537]; transcription by RNA polymerase II [GO:0006366]; ureter morphogenesis [GO:0072197]; ureteric bud development [GO:0001657]; urogenital system development [GO:0001655]; uterine epithelium development [GO:0035847]; uterus development [GO:0060065]; vagina development [GO:0060068]; ventral spinal cord development [GO:0021517]	chromatin [GO:0000785]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; anterior/posterior pattern specification [GO:0009952]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell signaling [GO:0007267]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [GO:0021937]; cerebellum development [GO:0021549]; cervix development [GO:0060067]; comma-shaped body morphogenesis [GO:0072049]; dorsal spinal cord interneuron posterior axon guidance [GO:0097379]; dorsal/ventral pattern formation [GO:0009953]; ectoderm formation [GO:0001705]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; embryonic viscerocranium morphogenesis [GO:0048703]; endoderm formation [GO:0001706]; epithelium development [GO:0060429]; forebrain regionalization [GO:0021871]; gastrulation with mouth forming second [GO:0001702]; head development [GO:0060322]; kidney development [GO:0001822]; lateral motor column neuron migration [GO:0097477]; mesendoderm development [GO:0048382]; mesonephric duct development [GO:0072177]; metanephric comma-shaped body morphogenesis [GO:0072278]; metanephric glomerulus development [GO:0072224]; metanephric part of ureteric bud development [GO:0035502]; metanephric renal vesicle morphogenesis [GO:0072283]; metanephric S-shaped body morphogenesis [GO:0072284]; motor neuron axon guidance [GO:0008045]; negative regulation of DNA-templated transcription [GO:0045892]; nephric duct elongation [GO:0035849]; nephric duct morphogenesis [GO:0072178]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; oviduct development [GO:0060066]; oviduct epithelium development [GO:0035846]; paramesonephric duct development [GO:0061205]; pattern specification process [GO:0007389]; positive regulation of anterior head development [GO:2000744]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; post-embryonic development [GO:0009791]; primitive streak formation [GO:0090009]; pronephros development [GO:0048793]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; renal vesicle morphogenesis [GO:0072077]; retina layer formation [GO:0010842]; S-shaped body morphogenesis [GO:0072050]; somite rostral/caudal axis specification [GO:0032525]; spinal cord association neuron differentiation [GO:0021527]; telencephalon development [GO:0021537]; transcription by RNA polymerase II [GO:0006366]; ureter morphogenesis [GO:0072197]; ureteric bud development [GO:0001657]; urogenital system development [GO:0001655]; uterine epithelium development [GO:0035847]; uterus development [GO:0060065]; vagina development [GO:0060068]; ventral spinal cord development [GO:0021517]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P48745	reviewed	CCN3_HUMAN	CCN family member 3 (Cellular communication network factor 3) (Insulin-like growth factor-binding protein 9) (IBP-9) (IGF-binding protein 9) (IGFBP-9) (Nephro blastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH)	CCN3 IGFBP9 NOV NOVH	Homo sapiens (Human)	357	FUNCTION: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891). {ECO:0000250|UniProtKB:Q64299, ECO:0000269|PubMed:12050162, ECO:0000269|PubMed:12695522, ECO:0000269|PubMed:15181016, ECO:0000269|PubMed:15611078, ECO:0000269|PubMed:17463287, ECO:0000269|PubMed:20139355, ECO:0000269|PubMed:21063504, ECO:0000269|PubMed:21344378, ECO:0000269|PubMed:21871891}.		angiogenesis [GO:0001525]; bone regeneration [GO:1990523]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell chemotaxis [GO:0060326]; chondrocyte differentiation [GO:0002062]; endothelial cell chemotaxis [GO:0035767]; endothelial cell-cell adhesion [GO:0071603]; fibroblast migration [GO:0010761]; hematopoietic stem cell homeostasis [GO:0061484]; negative regulation of cell growth [GO:0030308]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin secretion [GO:0046676]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of sensory perception of pain [GO:1904057]; negative regulation of SMAD protein signal transduction [GO:0060392]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of gene expression [GO:0010468]; signal transduction [GO:0007165]; smooth muscle cell migration [GO:0014909]; smooth muscle cell proliferation [GO:0048659]; type B pancreatic cell proliferation [GO:0044342]	axon [GO:0030424]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; gap junction [GO:0005921]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]	growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; Notch binding [GO:0005112]	axon [GO:0030424]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; gap junction [GO:0005921]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; Notch binding [GO:0005112]; angiogenesis [GO:0001525]; bone regeneration [GO:1990523]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell chemotaxis [GO:0060326]; chondrocyte differentiation [GO:0002062]; endothelial cell chemotaxis [GO:0035767]; endothelial cell-cell adhesion [GO:0071603]; fibroblast migration [GO:0010761]; hematopoietic stem cell homeostasis [GO:0061484]; negative regulation of cell growth [GO:0030308]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin secretion [GO:0046676]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of sensory perception of pain [GO:1904057]; negative regulation of SMAD protein signal transduction [GO:0060392]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of gene expression [GO:0010468]; signal transduction [GO:0007165]; smooth muscle cell migration [GO:0014909]; smooth muscle cell proliferation [GO:0048659]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Secreted. Cytoplasm {ECO:0000269|PubMed:15181016}. Cell junction, gap junction {ECO:0000269|PubMed:15181016}. Note=Localizes at the gap junction in presence of GJA1. {ECO:0000250|UniProtKB:Q9QZQ5}.
P48751	reviewed	B3A3_HUMAN	Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3)	SLC4A3 AE3	Homo sapiens (Human)	1232	FUNCTION: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:7923606, PubMed:29167417). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417). {ECO:0000269|PubMed:29167417, ECO:0000269|PubMed:7923606}.		bicarbonate transport [GO:0015701]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential [GO:0086001]; pH reduction [GO:0045851]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride:bicarbonate antiporter activity [GO:0140900]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride:bicarbonate antiporter activity [GO:0140900]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857]; bicarbonate transport [GO:0015701]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential [GO:0086001]; pH reduction [GO:0045851]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29167417}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform CAE3]: Cell membrane {ECO:0000305|PubMed:7923606}; Multi-pass membrane protein {ECO:0000255}.
P48764	reviewed	SL9A3_HUMAN	Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3)	SLC9A3 NHE3	Homo sapiens (Human)	834	FUNCTION: Plasma membrane Na(+)/H(+) antiporter (PubMed:26358773, PubMed:35613257, PubMed:18829453). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:26358773, PubMed:24622516). {ECO:0000250|UniProtKB:G3X939, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:24622516, ECO:0000269|PubMed:26358773, ECO:0000269|PubMed:35613257}.		monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; phosphatidylinositol binding [GO:0035091]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; phosphatidylinositol binding [GO:0035091]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:19088451, ECO:0000269|PubMed:26358773}; Multi-pass membrane protein {ECO:0000269|PubMed:35613257}. Cell membrane {ECO:0000269|PubMed:25851603, ECO:0000269|PubMed:35613257}; Multi-pass membrane protein {ECO:0000269|PubMed:35613257}. Recycling endosome membrane {ECO:0000269|PubMed:35613257}; Multi-pass membrane protein {ECO:0000269|PubMed:35613257}. Early endosome membrane {ECO:0000269|PubMed:25851603}; Multi-pass membrane protein {ECO:0000269|PubMed:35613257}. Note=In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity). {ECO:0000250|UniProtKB:Q28362}.
P48775	reviewed	T23O_HUMAN	Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)	TDO2 TDO	Homo sapiens (Human)	406	FUNCTION: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. {ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:25066423, ECO:0000269|PubMed:27762317, ECO:0000269|PubMed:28285122}.		protein homotetramerization [GO:0051289]; response to nitroglycerin [GO:1904842]; tryptophan catabolic process to acetyl-CoA [GO:0019442]; tryptophan catabolic process to kynurenine [GO:0019441]	cytosol [GO:0005829]	amino acid binding [GO:0016597]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; tryptophan 2,3-dioxygenase activity [GO:0004833]	cytosol [GO:0005829]; amino acid binding [GO:0016597]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; tryptophan 2,3-dioxygenase activity [GO:0004833]; protein homotetramerization [GO:0051289]; response to nitroglycerin [GO:1904842]; tryptophan catabolic process to acetyl-CoA [GO:0019442]; tryptophan catabolic process to kynurenine [GO:0019441]	
P48788	reviewed	TNNI2_HUMAN	Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)	TNNI2	Homo sapiens (Human)	182	FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.		cardiac muscle contraction [GO:0060048]; positive regulation of DNA-templated transcription [GO:0045893]; relaxation of skeletal muscle [GO:0090076]; skeletal muscle contraction [GO:0003009]	cytosol [GO:0005829]; nucleus [GO:0005634]; troponin complex [GO:0005861]	actin binding [GO:0003779]; troponin T binding [GO:0031014]	cytosol [GO:0005829]; nucleus [GO:0005634]; troponin complex [GO:0005861]; actin binding [GO:0003779]; troponin T binding [GO:0031014]; cardiac muscle contraction [GO:0060048]; positive regulation of DNA-templated transcription [GO:0045893]; relaxation of skeletal muscle [GO:0090076]; skeletal muscle contraction [GO:0003009]	
P48960	reviewed	AGRE5_HUMAN	Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta]	ADGRE5 CD97	Homo sapiens (Human)	835	FUNCTION: Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. {ECO:0000250|UniProtKB:Q9Z0M6}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Z0M6}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Adhesion G protein-coupled receptor E5 subunit alpha]: Secreted, extracellular space {ECO:0000305}.
P48995	reviewed	TRPC1_HUMAN	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1)	TRPC1 TRP1	Homo sapiens (Human)	793	FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. {ECO:0000269|PubMed:15016832}.		calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; melanin biosynthetic process [GO:0042438]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to calcium ion [GO:0051592]	cation channel complex [GO:0034703]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; monoatomic cation channel activity [GO:0005261]; signaling receptor binding [GO:0005102]; store-operated calcium channel activity [GO:0015279]; transmembrane transporter binding [GO:0044325]	cation channel complex [GO:0034703]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; monoatomic cation channel activity [GO:0005261]; signaling receptor binding [GO:0005102]; store-operated calcium channel activity [GO:0015279]; transmembrane transporter binding [GO:0044325]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; melanin biosynthetic process [GO:0042438]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P49005	reviewed	DPOD2_HUMAN	DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50)	POLD2	Homo sapiens (Human)	469	FUNCTION: Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:22801543, PubMed:17317665, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906). Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:12403614, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906}.		DNA biosynthetic process [GO:0071897]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276]	delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; zeta DNA polymerase complex [GO:0016035]	DNA binding [GO:0003677]	delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; zeta DNA polymerase complex [GO:0016035]; DNA binding [GO:0003677]; DNA biosynthetic process [GO:0071897]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22801543}. Note=Recruited to DNA damage sites within 2 hours following UV irradiation. {ECO:0000269|PubMed:22801543}.
P49006	reviewed	MRP_HUMAN	MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS)	MARCKSL1 MLP MRP	Homo sapiens (Human)	195	FUNCTION: Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}.		actin filament organization [GO:0007015]; cell population proliferation [GO:0008283]; central nervous system development [GO:0007417]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; actin filament organization [GO:0007015]; cell population proliferation [GO:0008283]; central nervous system development [GO:0007417]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P28667}. Cell membrane {ECO:0000305|PubMed:22751924, ECO:0000305|PubMed:25255805}; Lipid-anchor {ECO:0000305|PubMed:25255805}. Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin. Colocalizes with F-actin at the leading edge of migrating cells (By similarity). In prostate cancers, shows strong expression at apical and/or basal regions of the cell and also has weak cytoplasmic expression (PubMed:22751924). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}.
P49019	reviewed	HCAR3_HUMAN	Hydroxycarboxylic acid receptor 3 (G-protein coupled receptor 109B) (G-protein coupled receptor HM74) (G-protein coupled receptor HM74B) (Niacin receptor 2) (Nicotinic acid receptor 2)	HCAR3 GPR109B HCA3 HM74B NIACR2	Homo sapiens (Human)	387	FUNCTION: Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:19561068}.		G protein-coupled receptor signaling pathway [GO:0007186]	cell junction [GO:0030054]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; nicotinic acid receptor activity [GO:0070553]	cell junction [GO:0030054]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; nicotinic acid receptor activity [GO:0070553]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P49023	reviewed	PAXI_HUMAN	Paxillin	PXN	Homo sapiens (Human)	591	FUNCTION: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}.		cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; endothelial cell migration [GO:0043542]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of stress fiber assembly [GO:0051496]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	beta-catenin binding [GO:0008013]; metal ion binding [GO:0046872]; neuropilin binding [GO:0038191]; protein phosphatase binding [GO:0019903]; vinculin binding [GO:0017166]	cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; beta-catenin binding [GO:0008013]; metal ion binding [GO:0046872]; neuropilin binding [GO:0038191]; protein phosphatase binding [GO:0019903]; vinculin binding [GO:0017166]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; endothelial cell migration [GO:0043542]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of stress fiber assembly [GO:0051496]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20489202}. Cell junction, focal adhesion {ECO:0000269|PubMed:20489202, ECO:0000269|PubMed:23128389, ECO:0000269|PubMed:25015296}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q8VI36}. Note=Colocalizes with integrins at the cell periphery. Colocalize with PXN to membrane ruffles and the leading edge of migrating cells (PubMed:23128389). {ECO:0000250, ECO:0000269|PubMed:23128389}.
P49069	reviewed	CAMLG_HUMAN	Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand)	CAMLG CAML GET2	Homo sapiens (Human)	296	FUNCTION: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539). Required for the stability of GET1 (PubMed:32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304). Essential for the survival of peripheral follicular B cells (By similarity). {ECO:0000250|UniProtKB:P49070, ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:24392163, ECO:0000269|PubMed:27226539, ECO:0000269|PubMed:32187542, ECO:0000269|PubMed:7522304}.		B cell homeostasis [GO:0001782]; defense response [GO:0006952]; epidermal growth factor receptor signaling pathway [GO:0007173]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; protein insertion into ER membrane [GO:0045048]; protein stabilization [GO:0050821]; receptor recycling [GO:0001881]; signal transduction [GO:0007165]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; GET complex [GO:0043529]; membrane [GO:0016020]	ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; GET complex [GO:0043529]; membrane [GO:0016020]; ubiquitin protein ligase binding [GO:0031625]; B cell homeostasis [GO:0001782]; defense response [GO:0006952]; epidermal growth factor receptor signaling pathway [GO:0007173]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; protein insertion into ER membrane [GO:0045048]; protein stabilization [GO:0050821]; receptor recycling [GO:0001881]; signal transduction [GO:0007165]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:31417168}; Multi-pass membrane protein {ECO:0000255}.
P49116	reviewed	NR2C2_HUMAN	Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)	NR2C2 TAK1 TR4	Homo sapiens (Human)	596	FUNCTION: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}.		anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of embryonic development [GO:0040019]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of embryonic development [GO:0040019]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:15302918}.
P49137	reviewed	MAPK2_HUMAN	MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)	MAPKAPK2	Homo sapiens (Human)	400	FUNCTION: Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:11844797, ECO:0000269|PubMed:12456657, ECO:0000269|PubMed:12565831, ECO:0000269|PubMed:14499342, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:15629715, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:16456544, ECO:0000269|PubMed:17481585, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:8093612, ECO:0000269|PubMed:8280084, ECO:0000269|PubMed:8774846}.	MISCELLANEOUS: [Isoform 1]: Has a nuclear localization signal.	3'-UTR-mediated mRNA stabilization [GO:0070935]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; DNA damage response [GO:0006974]; inflammatory response [GO:0006954]; inner ear development [GO:0048839]; intracellular signal transduction [GO:0035556]; leukotriene metabolic process [GO:0006691]; macropinocytosis [GO:0044351]; MAPK cascade [GO:0000165]; p38MAPK cascade [GO:0038066]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of tumor necrosis factor production [GO:0032760]; protein phosphorylation [GO:0006468]; regulation of cellular response to heat [GO:1900034]; regulation of interleukin-6 production [GO:0032675]; regulation of mRNA stability [GO:0043488]; regulation of tumor necrosis factor production [GO:0032680]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; toll-like receptor signaling pathway [GO:0002224]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; mitogen-activated protein kinase binding [GO:0051019]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; mitogen-activated protein kinase binding [GO:0051019]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; DNA damage response [GO:0006974]; inflammatory response [GO:0006954]; inner ear development [GO:0048839]; intracellular signal transduction [GO:0035556]; leukotriene metabolic process [GO:0006691]; macropinocytosis [GO:0044351]; MAPK cascade [GO:0000165]; p38MAPK cascade [GO:0038066]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of tumor necrosis factor production [GO:0032760]; protein phosphorylation [GO:0006468]; regulation of cellular response to heat [GO:1900034]; regulation of interleukin-6 production [GO:0032675]; regulation of mRNA stability [GO:0043488]; regulation of tumor necrosis factor production [GO:0032680]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; toll-like receptor signaling pathway [GO:0002224]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20932473}. Nucleus {ECO:0000269|PubMed:20932473}. Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm.
P49146	reviewed	NPY2R_HUMAN	Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor)	NPY2R	Homo sapiens (Human)	381	FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cardiac left ventricle morphogenesis [GO:0003214]; locomotory behavior [GO:0007626]; outflow tract morphogenesis [GO:0003151]	cilium [GO:0005929]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]	calcium channel regulator activity [GO:0005246]; neuropeptide Y receptor activity [GO:0004983]; peptide YY receptor activity [GO:0001601]; signaling receptor activity [GO:0038023]	cilium [GO:0005929]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; calcium channel regulator activity [GO:0005246]; neuropeptide Y receptor activity [GO:0004983]; peptide YY receptor activity [GO:0001601]; signaling receptor activity [GO:0038023]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cardiac left ventricle morphogenesis [GO:0003214]; locomotory behavior [GO:0007626]; outflow tract morphogenesis [GO:0003151]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P49184	reviewed	DNSL1_HUMAN	Deoxyribonuclease-1-like 1 (EC 3.1.21.-) (DNase X) (Deoxyribonuclease I-like 1) (DNase I-like 1) (Muscle-specific DNase I-like) (XIB)	DNASE1L1 DNAS1L1 DNL1L	Homo sapiens (Human)	302			DNA catabolic process [GO:0006308]; DNA metabolic process [GO:0006259]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]	deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]; DNA nuclease activity [GO:0004536]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]; deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]; DNA nuclease activity [GO:0004536]; DNA catabolic process [GO:0006308]; DNA metabolic process [GO:0006259]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:16107205}.
P49189	reviewed	AL9A1_HUMAN	4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed]	ALDH9A1 ALDH4 ALDH7 ALDH9	Homo sapiens (Human)	494	FUNCTION: Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. {ECO:0000269|PubMed:10702312, ECO:0000269|PubMed:30914451, ECO:0000269|PubMed:8645224}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation. Contains a predicted signal peptide at positions 1-24. {ECO:0000305}.	carnitine biosynthetic process [GO:0045329]; cellular aldehyde metabolic process [GO:0006081]; hormone metabolic process [GO:0042445]; neurotransmitter biosynthetic process [GO:0042136]; protein homotetramerization [GO:0051289]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	1-pyrroline dehydrogenase activity [GO:0033737]; 4-trimethylammoniobutyraldehyde dehydrogenase activity [GO:0047105]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aminobutyraldehyde dehydrogenase activity [GO:0019145]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; small molecule binding [GO:0036094]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 1-pyrroline dehydrogenase activity [GO:0033737]; 4-trimethylammoniobutyraldehyde dehydrogenase activity [GO:0047105]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aminobutyraldehyde dehydrogenase activity [GO:0019145]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; small molecule binding [GO:0036094]; carnitine biosynthetic process [GO:0045329]; cellular aldehyde metabolic process [GO:0006081]; hormone metabolic process [GO:0042445]; neurotransmitter biosynthetic process [GO:0042136]; protein homotetramerization [GO:0051289]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JLJ3}.
P49190	reviewed	PTH2R_HUMAN	Parathyroid hormone 2 receptor (PTH2 receptor)	PTH2R PTHR2	Homo sapiens (Human)	550	FUNCTION: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). {ECO:0000250}.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cold-induced thermogenesis [GO:0120162]	plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; parathyroid hormone receptor activity [GO:0004991]; peptide hormone binding [GO:0017046]	plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; parathyroid hormone receptor activity [GO:0004991]; peptide hormone binding [GO:0017046]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cold-induced thermogenesis [GO:0120162]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P49207	reviewed	RL34_HUMAN	Large ribosomal subunit protein eL34 (60S ribosomal protein L34)	RPL34	Homo sapiens (Human)	117	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; synapse [GO:0045202]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; synapse [GO:0045202]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q29223}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q29223, ECO:0000269|PubMed:25957688}.
P49221	reviewed	TGM4_HUMAN	Protein-glutamine gamma-glutamyltransferase 4 (EC 2.3.2.13) (Fibrinoligase) (Prostate transglutaminase) (Prostate-specific transglutaminase) (Transglutaminase P) (TG(P)) (TGP) (TGase P) (Transglutaminase-4) (TGase-4)	TGM4	Homo sapiens (Human)	684	FUNCTION: Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.			collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]	metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	
P49238	reviewed	CX3C1_HUMAN	CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Beta chemokine receptor-like 1) (CMK-BRL-1) (CMK-BRL1) (Fractalkine receptor) (G-protein coupled receptor 13) (V28)	CX3CR1 CMKBRL1 GPR13	Homo sapiens (Human)	355	FUNCTION: Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:9390561, PubMed:9782118, PubMed:12055230, PubMed:23125415). CX3CR1-CX3CL1 signaling mediates cell migratory functions (By similarity). Responsible for the recruitment of natural killer (NK) cells to inflamed tissues (By similarity). Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (By similarity). Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (By similarity). Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (By similarity). Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis (PubMed:14581400, PubMed:18971423). Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (By similarity). Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli (By similarity). Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development (By similarity). Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development (By similarity). Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi (By similarity). Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria (By similarity). Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (PubMed:29326275). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (PubMed:20974991). {ECO:0000250|UniProtKB:Q9Z0D9, ECO:0000269|PubMed:12055230, ECO:0000269|PubMed:14581400, ECO:0000269|PubMed:18971423, ECO:0000269|PubMed:20974991, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:29326275, ECO:0000269|PubMed:9390561, ECO:0000269|PubMed:9782118}.; FUNCTION: [Isoform 1]: (Microbial infection) Acts as coreceptor with CD4 for HIV-1 virus envelope protein. {ECO:0000269|PubMed:14607932, ECO:0000269|PubMed:9726990}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as coreceptor with CD4 for HIV-1 virus envelope protein (PubMed:14607932). May have more potent HIV-1 coreceptothr activity than isoform 1 (PubMed:14607932). {ECO:0000269|PubMed:14607932}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as coreceptor with CD4 for HIV-1 virus envelope protein (PubMed:14607932). May have more potent HIV-1 coreceptor activity than isoform 1 (PubMed:14607932). {ECO:0000269|PubMed:14607932}.		adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; autocrine signaling [GO:0035425]; brain development [GO:0007420]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; central nervous system maturation [GO:0021626]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; immune response [GO:0006955]; innate immune response [GO:0045087]; leukocyte chemotaxis [GO:0030595]; leukocyte tethering or rolling [GO:0050901]; memory [GO:0007613]; microglial cell activation involved in immune response [GO:0002282]; modulation of chemical synaptic transmission [GO:0050804]; multiple spine synapse organization, single dendrite [GO:0150090]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell migration [GO:0030336]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of microglial cell mediated cytotoxicity [GO:1904150]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neurogenesis [GO:0050769]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of microglial cell migration [GO:1904139]; regulation of neurogenesis [GO:0050767]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of synaptic plasticity [GO:0048167]; regulation of tumor necrosis factor production [GO:0032680]; response to ischemia [GO:0002931]; response to wounding [GO:0009611]; social behavior [GO:0035176]; synapse maturation [GO:0060074]; synapse pruning [GO:0098883]	cell surface [GO:0009986]; dendritic tree [GO:0097447]; external side of plasma membrane [GO:0009897]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X3-C chemokine binding [GO:0019960]; C-X3-C chemokine receptor activity [GO:0016495]; chemokine receptor activity [GO:0004950]; CX3C chemokine receptor binding [GO:0031737]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]	cell surface [GO:0009986]; dendritic tree [GO:0097447]; external side of plasma membrane [GO:0009897]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X3-C chemokine binding [GO:0019960]; C-X3-C chemokine receptor activity [GO:0016495]; chemokine receptor activity [GO:0004950]; CX3C chemokine receptor binding [GO:0031737]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; autocrine signaling [GO:0035425]; brain development [GO:0007420]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; central nervous system maturation [GO:0021626]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; immune response [GO:0006955]; innate immune response [GO:0045087]; leukocyte chemotaxis [GO:0030595]; leukocyte tethering or rolling [GO:0050901]; memory [GO:0007613]; microglial cell activation involved in immune response [GO:0002282]; modulation of chemical synaptic transmission [GO:0050804]; multiple spine synapse organization, single dendrite [GO:0150090]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell migration [GO:0030336]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of microglial cell mediated cytotoxicity [GO:1904150]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neurogenesis [GO:0050769]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of microglial cell migration [GO:1904139]; regulation of neurogenesis [GO:0050767]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of synaptic plasticity [GO:0048167]; regulation of tumor necrosis factor production [GO:0032680]; response to ischemia [GO:0002931]; response to wounding [GO:0009611]; social behavior [GO:0035176]; synapse maturation [GO:0060074]; synapse pruning [GO:0098883]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12055230, ECO:0000269|PubMed:28791023, ECO:0000269|PubMed:9390561}; Multi-pass membrane protein {ECO:0000255}.
P49247	reviewed	RPIA_HUMAN	Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase)	RPIA RPI	Homo sapiens (Human)	311	FUNCTION: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate and participates in the first step of the non-oxidative branch of the pentose phosphate pathway. {ECO:0000269|PubMed:14988808}.		D-ribose metabolic process [GO:0006014]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]	cytosol [GO:0005829]	identical protein binding [GO:0042802]; monosaccharide binding [GO:0048029]; ribose-5-phosphate isomerase activity [GO:0004751]	cytosol [GO:0005829]; identical protein binding [GO:0042802]; monosaccharide binding [GO:0048029]; ribose-5-phosphate isomerase activity [GO:0004751]; D-ribose metabolic process [GO:0006014]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]	
P49257	reviewed	LMAN1_HUMAN	Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Gp58) (Intracellular mannose-specific lectin MR60) (Lectin mannose-binding 1)	LMAN1 ERGIC53 F5F8D	Homo sapiens (Human)	510	FUNCTION: Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. {ECO:0000269|PubMed:12717434, ECO:0000269|PubMed:13130098}.		blood coagulation [GO:0007596]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; negative regulation of protein targeting to mitochondrion [GO:1903215]; positive regulation of organelle organization [GO:0010638]; protein folding [GO:0006457]; protein transport [GO:0015031]	collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; sarcomere [GO:0030017]	mannose binding [GO:0005537]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082]	collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; sarcomere [GO:0030017]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082]; blood coagulation [GO:0007596]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; negative regulation of protein targeting to mitochondrion [GO:1903215]; positive regulation of organelle organization [GO:0010638]; protein folding [GO:0006457]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
P49279	reviewed	NRAM1_HUMAN	Natural resistance-associated macrophage protein 1 (NRAMP 1) (Solute carrier family 11 member 1)	SLC11A1 LSH NRAMP NRAMP1	Homo sapiens (Human)	550	FUNCTION: Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity (PubMed:11237855). Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (Probable). {ECO:0000269|PubMed:11237855, ECO:0000305|PubMed:16103355, ECO:0000305|PubMed:16395392}.		activation of protein kinase activity [GO:0032147]; antigen processing and presentation of peptide antigen [GO:0048002]; antimicrobial humoral response [GO:0019730]; cadmium ion transmembrane transport [GO:0070574]; cell redox homeostasis [GO:0045454]; cellular detoxification of cadmium ion [GO:0098849]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to protozoan [GO:0042832]; establishment of localization in cell [GO:0051649]; inflammatory response [GO:0006954]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; L-arginine transmembrane transport [GO:1903826]; macrophage activation [GO:0042116]; manganese ion transport [GO:0006828]; metal ion transport [GO:0030001]; MHC class II biosynthetic process [GO:0045342]; mRNA stabilization [GO:0048255]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of cytokine production [GO:0001818]; nitrite transport [GO:0015707]; phagocytosis [GO:0006909]; positive regulation of cytokine production [GO:0001819]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; respiratory burst [GO:0045730]; response to bacterium [GO:0009617]; response to lipopolysaccharide [GO:0032496]; response to type II interferon [GO:0034341]; T cell proliferation involved in immune response [GO:0002309]; vacuolar acidification [GO:0007035]; wound healing [GO:0042060]	ficolin-1-rich granule membrane [GO:0101003]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	cadmium ion transmembrane transporter activity [GO:0015086]; iron ion transmembrane transporter activity [GO:0005381]; manganese ion transmembrane transporter activity [GO:0005384]; metal cation:proton antiporter activity [GO:0051139]; protein homodimerization activity [GO:0042803]; transition metal ion transmembrane transporter activity [GO:0046915]	ficolin-1-rich granule membrane [GO:0101003]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; cadmium ion transmembrane transporter activity [GO:0015086]; iron ion transmembrane transporter activity [GO:0005381]; manganese ion transmembrane transporter activity [GO:0005384]; metal cation:proton antiporter activity [GO:0051139]; protein homodimerization activity [GO:0042803]; transition metal ion transmembrane transporter activity [GO:0046915]; activation of protein kinase activity [GO:0032147]; antigen processing and presentation of peptide antigen [GO:0048002]; antimicrobial humoral response [GO:0019730]; cadmium ion transmembrane transport [GO:0070574]; cell redox homeostasis [GO:0045454]; cellular detoxification of cadmium ion [GO:0098849]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to protozoan [GO:0042832]; establishment of localization in cell [GO:0051649]; inflammatory response [GO:0006954]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; L-arginine transmembrane transport [GO:1903826]; macrophage activation [GO:0042116]; manganese ion transport [GO:0006828]; metal ion transport [GO:0030001]; MHC class II biosynthetic process [GO:0045342]; mRNA stabilization [GO:0048255]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of cytokine production [GO:0001818]; nitrite transport [GO:0015707]; phagocytosis [GO:0006909]; positive regulation of cytokine production [GO:0001819]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; respiratory burst [GO:0045730]; response to bacterium [GO:0009617]; response to lipopolysaccharide [GO:0032496]; response to type II interferon [GO:0034341]; T cell proliferation involved in immune response [GO:0002309]; vacuolar acidification [GO:0007035]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000305|PubMed:11237855}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000305|PubMed:11237855}; Multi-pass membrane protein {ECO:0000255}.
P49281	reviewed	NRAM2_HUMAN	Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2)	SLC11A2 DCT1 DMT1 NRAMP2 OK/SW-cl.20	Homo sapiens (Human)	568	FUNCTION: Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:17109629, PubMed:22736759, PubMed:25491917, PubMed:17293870, PubMed:25326704). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (PubMed:17109629, PubMed:22736759, PubMed:25491917, PubMed:17293870, PubMed:25326704). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (PubMed:24448823) (By similarity). Can mediate uncoupled fluxes of either protons or metal ions. {ECO:0000250|UniProtKB:O54902, ECO:0000250|UniProtKB:P49282, ECO:0000269|PubMed:17109629, ECO:0000269|PubMed:17293870, ECO:0000269|PubMed:22736759, ECO:0000269|PubMed:24448823, ECO:0000269|PubMed:25326704, ECO:0000269|PubMed:25491917}.	MISCELLANEOUS: NRAMP2-mediated iron uptake is markedly stimulated by nifedipine in a concentration-dependent manner.	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cadmium ion transmembrane transport [GO:0070574]; cellular response to oxidative stress [GO:0034599]; cobalt ion transport [GO:0006824]; copper ion transport [GO:0006825]; dendrite morphogenesis [GO:0048813]; detection of oxygen [GO:0003032]; erythrocyte development [GO:0048821]; heme biosynthetic process [GO:0006783]; intracellular iron ion homeostasis [GO:0006879]; iron import into cell [GO:0033212]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]; lead ion transport [GO:0015692]; learning or memory [GO:0007611]; manganese ion transport [GO:0006828]; multicellular organismal-level iron ion homeostasis [GO:0060586]; nickel cation transport [GO:0015675]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; vanadium ion transport [GO:0015676]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basal part of cell [GO:0045178]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; paraferritin complex [GO:0070826]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773]	cadmium ion binding [GO:0046870]; cadmium ion transmembrane transporter activity [GO:0015086]; cobalt ion transmembrane transporter activity [GO:0015087]; copper ion transmembrane transporter activity [GO:0005375]; ferrous iron transmembrane transporter activity [GO:0015093]; inorganic cation transmembrane transporter activity [GO:0022890]; iron ion transmembrane transporter activity [GO:0005381]; lead ion transmembrane transporter activity [GO:0015094]; manganese ion transmembrane transporter activity [GO:0005384]; nickel cation transmembrane transporter activity [GO:0015099]; retromer complex binding [GO:1905394]; solute:proton symporter activity [GO:0015295]; transition metal ion transmembrane transporter activity [GO:0046915]; vanadium ion transmembrane transporter activity [GO:0015100]; zinc ion transmembrane transporter activity [GO:0005385]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basal part of cell [GO:0045178]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; paraferritin complex [GO:0070826]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773]; cadmium ion binding [GO:0046870]; cadmium ion transmembrane transporter activity [GO:0015086]; cobalt ion transmembrane transporter activity [GO:0015087]; copper ion transmembrane transporter activity [GO:0005375]; ferrous iron transmembrane transporter activity [GO:0015093]; inorganic cation transmembrane transporter activity [GO:0022890]; iron ion transmembrane transporter activity [GO:0005381]; lead ion transmembrane transporter activity [GO:0015094]; manganese ion transmembrane transporter activity [GO:0005384]; nickel cation transmembrane transporter activity [GO:0015099]; retromer complex binding [GO:1905394]; solute:proton symporter activity [GO:0015295]; transition metal ion transmembrane transporter activity [GO:0046915]; vanadium ion transmembrane transporter activity [GO:0015100]; zinc ion transmembrane transporter activity [GO:0005385]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cadmium ion transmembrane transport [GO:0070574]; cellular response to oxidative stress [GO:0034599]; cobalt ion transport [GO:0006824]; copper ion transport [GO:0006825]; dendrite morphogenesis [GO:0048813]; detection of oxygen [GO:0003032]; erythrocyte development [GO:0048821]; heme biosynthetic process [GO:0006783]; intracellular iron ion homeostasis [GO:0006879]; iron import into cell [GO:0033212]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]; lead ion transport [GO:0015692]; learning or memory [GO:0007611]; manganese ion transport [GO:0006828]; multicellular organismal-level iron ion homeostasis [GO:0060586]; nickel cation transport [GO:0015675]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; vanadium ion transport [GO:0015676]	SUBCELLULAR LOCATION: [Isoform 1]: Early endosome membrane {ECO:0000269|PubMed:12475959}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12475959}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localizes in early endosomes that underlie the apical membrane of polarized epithelia. {ECO:0000269|PubMed:12475959}.; SUBCELLULAR LOCATION: [Isoform 2]: Late endosome membrane {ECO:0000269|PubMed:12475959}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:12475959}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12475959}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:27462458}; Multi-pass membrane protein {ECO:0000255}. Extracellular vesicle membrane {ECO:0000269|PubMed:27462458}; Multi-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:25491917}.; SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:24448823}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P49282}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:P49282}; Multi-pass membrane protein {ECO:0000255}.
P49286	reviewed	MTR1B_HUMAN	Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor)	MTNR1B	Homo sapiens (Human)	362	FUNCTION: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.		camera-type eye development [GO:0043010]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose homeostasis [GO:0042593]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of insulin secretion [GO:0046676]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transmission of nerve impulse [GO:0051970]; negative regulation of vasoconstriction [GO:0045906]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of insulin secretion [GO:0050796]; regulation of neuronal action potential [GO:0098908]	plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled receptor activity [GO:0004930]; melatonin receptor activity [GO:0008502]	plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled receptor activity [GO:0004930]; melatonin receptor activity [GO:0008502]; camera-type eye development [GO:0043010]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose homeostasis [GO:0042593]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of insulin secretion [GO:0046676]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transmission of nerve impulse [GO:0051970]; negative regulation of vasoconstriction [GO:0045906]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of insulin secretion [GO:0050796]; regulation of neuronal action potential [GO:0098908]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P49321	reviewed	NASP_HUMAN	Nuclear autoantigenic sperm protein (NASP)	NASP	Homo sapiens (Human)	788	FUNCTION: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9}.		blastocyst development [GO:0001824]; cell cycle [GO:0007049]; CENP-A containing chromatin assembly [GO:0034080]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; male gonad development [GO:0008584]; nucleosome assembly [GO:0006334]; protein transport [GO:0015031]; response to testosterone [GO:0033574]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	histone binding [GO:0042393]; protein-containing complex binding [GO:0044877]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; histone binding [GO:0042393]; protein-containing complex binding [GO:0044877]; blastocyst development [GO:0001824]; cell cycle [GO:0007049]; CENP-A containing chromatin assembly [GO:0034080]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; male gonad development [GO:0008584]; nucleosome assembly [GO:0006334]; protein transport [GO:0015031]; response to testosterone [GO:0033574]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99MD9}. Nucleus {ECO:0000250|UniProtKB:Q99MD9}.
P49326	reviewed	FMO5_HUMAN	Flavin-containing monooxygenase 5 (FMO 5) (Baeyer-Villiger monooxygenase 1) (hBVMO1) (EC 1.14.13.-) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (NADPH oxidase) (EC 1.6.3.1)	FMO5	Homo sapiens (Human)	533	FUNCTION: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (PubMed:28783300, PubMed:26771671, PubMed:20947616). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive (PubMed:26771671, PubMed:7872795). In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline (PubMed:28783300). Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (PubMed:26771671). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). {ECO:0000250|UniProtKB:P97872, ECO:0000269|PubMed:20947616, ECO:0000269|PubMed:26771671, ECO:0000269|PubMed:28783300, ECO:0000269|PubMed:7872795, ECO:0000305|PubMed:26771671}.		lipid metabolic process [GO:0006629]; NADPH oxidation [GO:0070995]; regulation of cholesterol metabolic process [GO:0090181]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	aldehyde oxidase activity [GO:0004031]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; NADPH oxidase H202-forming activity [GO:0106294]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; aldehyde oxidase activity [GO:0004031]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; NADPH oxidase H202-forming activity [GO:0106294]; lipid metabolic process [GO:0006629]; NADPH oxidation [GO:0070995]; regulation of cholesterol metabolic process [GO:0090181]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305|PubMed:20947616}. Endoplasmic reticulum membrane.
P49327	reviewed	FAS_HUMAN	Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]	FASN FAS	Homo sapiens (Human)	2511	FUNCTION: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}.	MISCELLANEOUS: The relatively low beta-ketoacyl synthase activity may be attributable to the low 4'-phosphopantetheine content of the protein.	cellular response to interleukin-4 [GO:0071353]; establishment of endothelial intestinal barrier [GO:0090557]; ether lipid biosynthetic process [GO:0008611]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; glandular epithelial cell development [GO:0002068]; inflammatory response [GO:0006954]; mammary gland development [GO:0030879]; modulation by host of viral process [GO:0044788]; monocyte differentiation [GO:0030224]; neutrophil differentiation [GO:0030223]; osteoblast differentiation [GO:0001649]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycogen granule [GO:0042587]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity [GO:0008693]; (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity [GO:0047451]; (3R)-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity [GO:0047450]; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity [GO:0008659]; (3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [GO:0004317]; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; [acyl-carrier-protein] S-acetyltransferase activity [GO:0004313]; [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; cadherin binding [GO:0045296]; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity [GO:0047117]; fatty acid synthase activity [GO:0004312]; myristoyl-[acyl-carrier-protein] hydrolase activity [GO:0016295]; oleoyl-[acyl-carrier-protein] hydrolase activity [GO:0004320]; palmitoyl-[acyl-carrier-protein] hydrolase activity [GO:0016296]; phosphopantetheine binding [GO:0031177]; RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycogen granule [GO:0042587]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity [GO:0008693]; (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity [GO:0047451]; (3R)-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity [GO:0047450]; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity [GO:0008659]; (3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [GO:0004317]; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; [acyl-carrier-protein] S-acetyltransferase activity [GO:0004313]; [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; cadherin binding [GO:0045296]; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity [GO:0047117]; fatty acid synthase activity [GO:0004312]; myristoyl-[acyl-carrier-protein] hydrolase activity [GO:0016295]; oleoyl-[acyl-carrier-protein] hydrolase activity [GO:0004320]; palmitoyl-[acyl-carrier-protein] hydrolase activity [GO:0016296]; phosphopantetheine binding [GO:0031177]; RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; cellular response to interleukin-4 [GO:0071353]; establishment of endothelial intestinal barrier [GO:0090557]; ether lipid biosynthetic process [GO:0008611]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; glandular epithelial cell development [GO:0002068]; inflammatory response [GO:0006954]; mammary gland development [GO:0030879]; modulation by host of viral process [GO:0044788]; monocyte differentiation [GO:0030224]; neutrophil differentiation [GO:0030223]; osteoblast differentiation [GO:0001649]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
P49335	reviewed	PO3F4_HUMAN	POU domain, class 3, transcription factor 4 (Brain-specific homeobox/POU domain protein 4) (Brain-4) (Brn-4) (Octamer-binding protein 9) (Oct-9) (Octamer-binding transcription factor 9) (OTF-9)	POU3F4 BRN4 OTF9	Homo sapiens (Human)	361	FUNCTION: Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.		brain development [GO:0007420]; cochlea morphogenesis [GO:0090103]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; brain development [GO:0007420]; cochlea morphogenesis [GO:0090103]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Nucleus.
P49336	reviewed	CDK8_HUMAN	Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)	CDK8	Homo sapiens (Human)	464	FUNCTION: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. {ECO:0000269|PubMed:10993082, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:30905399}.		phosphorylation [GO:0016310]	CKM complex [GO:1990508]; mediator complex [GO:0016592]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]	CKM complex [GO:1990508]; mediator complex [GO:0016592]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P49354	reviewed	FNTA_HUMAN	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)	FNTA	Homo sapiens (Human)	379	FUNCTION: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}.		neurotransmitter receptor metabolic process [GO:0045213]; positive regulation of deacetylase activity [GO:0090045]; positive regulation of tubulin deacetylation [GO:0090044]; protein farnesylation [GO:0018343]; protein geranylgeranylation [GO:0018344]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; transforming growth factor beta receptor signaling pathway [GO:0007179]	CAAX-protein geranylgeranyltransferase complex [GO:0005953]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; protein farnesyltransferase complex [GO:0005965]	acetylcholine receptor regulator activity [GO:0030548]; alpha-tubulin binding [GO:0043014]; CAAX-protein geranylgeranyltransferase activity [GO:0004662]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; protein farnesyltransferase activity [GO:0004660]; protein geranylgeranyltransferase activity [GO:0004661]; Rab geranylgeranyltransferase activity [GO:0004663]; receptor tyrosine kinase binding [GO:0030971]	CAAX-protein geranylgeranyltransferase complex [GO:0005953]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; protein farnesyltransferase complex [GO:0005965]; acetylcholine receptor regulator activity [GO:0030548]; alpha-tubulin binding [GO:0043014]; CAAX-protein geranylgeranyltransferase activity [GO:0004662]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; protein farnesyltransferase activity [GO:0004660]; protein geranylgeranyltransferase activity [GO:0004661]; Rab geranylgeranyltransferase activity [GO:0004663]; receptor tyrosine kinase binding [GO:0030971]; neurotransmitter receptor metabolic process [GO:0045213]; positive regulation of deacetylase activity [GO:0090045]; positive regulation of tubulin deacetylation [GO:0090044]; protein farnesylation [GO:0018343]; protein geranylgeranylation [GO:0018344]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; transforming growth factor beta receptor signaling pathway [GO:0007179]	
P49356	reviewed	FNTB_HUMAN	Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta)	FNTB	Homo sapiens (Human)	437	FUNCTION: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}.		lipid metabolic process [GO:0006629]; protein farnesylation [GO:0018343]	cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; protein farnesyltransferase complex [GO:0005965]	protein farnesyltransferase activity [GO:0004660]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; protein farnesyltransferase complex [GO:0005965]; protein farnesyltransferase activity [GO:0004660]; zinc ion binding [GO:0008270]; lipid metabolic process [GO:0006629]; protein farnesylation [GO:0018343]	
P49366	reviewed	DHYS_HUMAN	Deoxyhypusine synthase (DHS) (EC 2.5.1.46)	DHPS DS	Homo sapiens (Human)	369	FUNCTION: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. {ECO:0000269|PubMed:30661771}.	MISCELLANEOUS: [Isoform Short]: Inactive. {ECO:0000305}.	glucose homeostasis [GO:0042593]; peptidyl-lysine modification to peptidyl-hypusine [GO:0008612]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of T cell proliferation [GO:0042102]; spermidine catabolic process [GO:0046203]; spermidine metabolic process [GO:0008216]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	deoxyhypusine synthase activity [GO:0034038]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; deoxyhypusine synthase activity [GO:0034038]; identical protein binding [GO:0042802]; glucose homeostasis [GO:0042593]; peptidyl-lysine modification to peptidyl-hypusine [GO:0008612]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of T cell proliferation [GO:0042102]; spermidine catabolic process [GO:0046203]; spermidine metabolic process [GO:0008216]; translation [GO:0006412]	
P49368	reviewed	TCPG_HUMAN	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (hTRiC5)	CCT3 CCTG TRIC5	Homo sapiens (Human)	545	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.		binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; zona pellucida receptor complex [GO:0002199]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]	cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; zona pellucida receptor complex [GO:0002199]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P49407	reviewed	ARRB1_HUMAN	Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)	ARRB1 ARR1	Homo sapiens (Human)	418	FUNCTION: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3. Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates in the recruitment of the ubiquitin-protein ligase to the receptor (PubMed:23886940). {ECO:0000250, ECO:0000269|PubMed:12464600, ECO:0000269|PubMed:14711824, ECO:0000269|PubMed:15475570, ECO:0000269|PubMed:15611106, ECO:0000269|PubMed:15671180, ECO:0000269|PubMed:15878855, ECO:0000269|PubMed:16144840, ECO:0000269|PubMed:16280323, ECO:0000269|PubMed:16378096, ECO:0000269|PubMed:16492667, ECO:0000269|PubMed:16709866, ECO:0000269|PubMed:18337459, ECO:0000269|PubMed:18419762, ECO:0000269|PubMed:19620252, ECO:0000269|PubMed:19643177, ECO:0000269|PubMed:22457824, ECO:0000269|PubMed:23341447, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:23886940}.		G protein-coupled receptor internalization [GO:0002031]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; stress fiber assembly [GO:0043149]; ubiquitin-dependent protein catabolic process [GO:0006511]; visual perception [GO:0007601]	chromatin [GO:0000785]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]	angiotensin receptor binding [GO:0031701]; arrestin family protein binding [GO:1990763]; enzyme inhibitor activity [GO:0004857]; G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; insulin-like growth factor receptor binding [GO:0005159]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; angiotensin receptor binding [GO:0031701]; arrestin family protein binding [GO:1990763]; enzyme inhibitor activity [GO:0004857]; G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; insulin-like growth factor receptor binding [GO:0005159]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]; G protein-coupled receptor internalization [GO:0002031]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; stress fiber assembly [GO:0043149]; ubiquitin-dependent protein catabolic process [GO:0006511]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit {ECO:0000305}. Cell projection, pseudopodium {ECO:0000250}. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). {ECO:0000250}.
P49411	reviewed	EFTU_HUMAN	Elongation factor Tu, mitochondrial (EF-Tu) (P43)	TUFM	Homo sapiens (Human)	455	FUNCTION: Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. {ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:28407488}.		mitochondrial translational elongation [GO:0070125]; response to ethanol [GO:0045471]; translational elongation [GO:0006414]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; synapse [GO:0045202]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; synapse [GO:0045202]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; mitochondrial translational elongation [GO:0070125]; response to ethanol [GO:0045471]; translational elongation [GO:0006414]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22749352}.
P49418	reviewed	AMPH_HUMAN	Amphiphysin	AMPH AMPH1	Homo sapiens (Human)	695	FUNCTION: May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.	MISCELLANEOUS: Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms.	chemical synaptic transmission [GO:0007268]; endocytosis [GO:0006897]; synaptic vesicle endocytosis [GO:0048488]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; leading edge membrane [GO:0031256]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	phospholipid binding [GO:0005543]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; leading edge membrane [GO:0031256]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; phospholipid binding [GO:0005543]; chemical synaptic transmission [GO:0007268]; endocytosis [GO:0006897]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
P49419	reviewed	AL7A1_HUMAN	Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase)	ALDH7A1 ATQ1	Homo sapiens (Human)	539	FUNCTION: Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. {ECO:0000269|PubMed:16491085, ECO:0000269|PubMed:20207735, ECO:0000269|PubMed:21338592}.		cellular aldehyde metabolic process [GO:0006081]; choline catabolic process [GO:0042426]; glycine betaine biosynthetic process from choline [GO:0019285]; sensory perception of sound [GO:0007605]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	aldehyde dehydrogenase (NAD+) activity [GO:0004029]; betaine-aldehyde dehydrogenase activity [GO:0008802]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; identical protein binding [GO:0042802]; L-aminoadipate-semialdehyde dehydrogenase activity [GO:0004043]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; betaine-aldehyde dehydrogenase activity [GO:0008802]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; identical protein binding [GO:0042802]; L-aminoadipate-semialdehyde dehydrogenase activity [GO:0004043]; cellular aldehyde metabolic process [GO:0006081]; choline catabolic process [GO:0042426]; glycine betaine biosynthetic process from choline [GO:0019285]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:20207735}. Nucleus {ECO:0000269|PubMed:20207735}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:20207735}.
P49427	reviewed	UB2R1_HUMAN	Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1)	CDC34 UBCH3 UBE2R1	Homo sapiens (Human)	236	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes (PubMed:10329681, PubMed:10373550, PubMed:10871850, PubMed:11675391, PubMed:12037680, PubMed:15652359, PubMed:17461777, PubMed:17698585, PubMed:19112177, PubMed:19126550, PubMed:19945379, PubMed:20061386, PubMed:20347421). {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:10373550, ECO:0000269|PubMed:10871850, ECO:0000269|PubMed:11675391, ECO:0000269|PubMed:12037680, ECO:0000269|PubMed:15652359, ECO:0000269|PubMed:17461777, ECO:0000269|PubMed:17698585, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:19126550, ECO:0000269|PubMed:19945379, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20347421, ECO:0000269|PubMed:22496338}.		cellular response to interferon-beta [GO:0035458]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of cAMP-mediated signaling [GO:0043951]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of neuron apoptotic process [GO:0043525]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein modification process [GO:0036211]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to growth factor [GO:0070848]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to interferon-beta [GO:0035458]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of cAMP-mediated signaling [GO:0043951]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of neuron apoptotic process [GO:0043525]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein modification process [GO:0036211]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to growth factor [GO:0070848]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase.
P49447	reviewed	CY561_HUMAN	Transmembrane ascorbate-dependent reductase CYB561 (EC 7.2.1.-) (Cytochrome b-561) (Cytochrome b561)	CYB561	Homo sapiens (Human)	251	FUNCTION: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles. It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes. {ECO:0000250|UniProtKB:P10897}.		ascorbate homeostasis [GO:0140576]; electron transport chain [GO:0022900]; intracellular iron ion homeostasis [GO:0006879]	chromaffin granule membrane [GO:0042584]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]	metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; transmembrane monodehydroascorbate reductase activity [GO:0140575]	chromaffin granule membrane [GO:0042584]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; transmembrane monodehydroascorbate reductase activity [GO:0140575]; ascorbate homeostasis [GO:0140576]; electron transport chain [GO:0022900]; intracellular iron ion homeostasis [GO:0006879]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P10897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Note=Secretory vesicle containing catecholamines and amidated peptides. {ECO:0000250|UniProtKB:P10897}.
P49448	reviewed	DHE4_HUMAN	Glutamate dehydrogenase 2, mitochondrial (GDH 2) (EC 1.4.1.3)	GLUD2 GLUDP1	Homo sapiens (Human)	558	FUNCTION: Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.		glutamate biosynthetic process [GO:0006537]; glutamate catabolic process [GO:0006538]; glutamate metabolic process [GO:0006536]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ADP binding [GO:0043531]; glutamate dehydrogenase (NAD+) activity [GO:0004352]; glutamate dehydrogenase (NADP+) activity [GO:0004354]; glutamate dehydrogenase [NAD(P)+] activity [GO:0004353]; GTP binding [GO:0005525]; leucine binding [GO:0070728]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ADP binding [GO:0043531]; glutamate dehydrogenase (NAD+) activity [GO:0004352]; glutamate dehydrogenase (NADP+) activity [GO:0004354]; glutamate dehydrogenase [NAD(P)+] activity [GO:0004353]; GTP binding [GO:0005525]; leucine binding [GO:0070728]; glutamate biosynthetic process [GO:0006537]; glutamate catabolic process [GO:0006538]; glutamate metabolic process [GO:0006536]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:22709669}.
P49450	reviewed	CENPA_HUMAN	Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)	CENPA	Homo sapiens (Human)	140	FUNCTION: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:21478274, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26878239, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683, ECO:0000305|PubMed:20739937}.	MISCELLANEOUS: Antibodies against CENPA are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins.	CENP-A containing chromatin assembly [GO:0034080]; establishment of mitotic spindle orientation [GO:0000132]; kinetochore assembly [GO:0051382]; mitotic cytokinesis [GO:0000281]; protein localization to CENP-A containing chromatin [GO:0061644]; protein localization to chromosome, centromeric region [GO:0071459]	CENP-A containing nucleosome [GO:0043505]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	CENP-A containing nucleosome [GO:0043505]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; CENP-A containing chromatin assembly [GO:0034080]; establishment of mitotic spindle orientation [GO:0000132]; kinetochore assembly [GO:0051382]; mitotic cytokinesis [GO:0000281]; protein localization to CENP-A containing chromatin [GO:0061644]; protein localization to chromosome, centromeric region [GO:0071459]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:9024683}. Chromosome, centromere {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:20739937, ECO:0000269|PubMed:21743476, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683}. Note=Localizes exclusively to sites of kinetochore assembly in centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (PubMed:19114591). Phosphorylation at Ser-68 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location (PubMed:25556658). {ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:25556658}.
P49454	reviewed	CENPF_HUMAN	Centromere protein F (CENP-F) (AH antigen) (Kinetochore protein CENPF) (Mitosin)	CENPF	Homo sapiens (Human)	3114	FUNCTION: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia. {ECO:0000269|PubMed:12974617, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:7542657, ECO:0000269|PubMed:7651420}.		cell differentiation [GO:0030154]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA biosynthetic process [GO:0071897]; kidney development [GO:0001822]; kinetochore assembly [GO:0051382]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly checkpoint signaling [GO:0007094]; muscle organ development [GO:0007517]; negative regulation of DNA-templated transcription [GO:0045892]; protein transport [GO:0015031]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of striated muscle tissue development [GO:0016202]; response to xenobiotic stimulus [GO:0009410]; ventricular system development [GO:0021591]	axoneme [GO:0005930]; centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; ciliary basal body [GO:0036064]; ciliary transition fiber [GO:0097539]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; perinuclear region of cytoplasm [GO:0048471]; pronucleus [GO:0045120]; spindle [GO:0005819]; spindle pole [GO:0000922]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]	axoneme [GO:0005930]; centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; ciliary basal body [GO:0036064]; ciliary transition fiber [GO:0097539]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; perinuclear region of cytoplasm [GO:0048471]; pronucleus [GO:0045120]; spindle [GO:0005819]; spindle pole [GO:0000922]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; cell differentiation [GO:0030154]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA biosynthetic process [GO:0071897]; kidney development [GO:0001822]; kinetochore assembly [GO:0051382]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly checkpoint signaling [GO:0007094]; muscle organ development [GO:0007517]; negative regulation of DNA-templated transcription [GO:0045892]; protein transport [GO:0015031]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of striated muscle tissue development [GO:0016202]; response to xenobiotic stimulus [GO:0009410]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At metaphase becomes localized to areas including kinetochore and mitotic apparatus as well as cytoplasm. By telophase, is concentrated within the intracellular bridge at either side of the mid-body.
P49458	reviewed	SRP09_HUMAN	Signal recognition particle 9 kDa protein (SRP9)	SRP9	Homo sapiens (Human)	86	FUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (PubMed:11089964). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity). {ECO:0000250|UniProtKB:P21262, ECO:0000269|PubMed:11089964}.		negative regulation of translational elongation [GO:0045900]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	cytosol [GO:0005829]; signal recognition particle receptor complex [GO:0005785]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]	7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]	cytosol [GO:0005829]; signal recognition particle receptor complex [GO:0005785]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]; negative regulation of translational elongation [GO:0045900]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	SUBCELLULAR LOCATION: Cytoplasm.
P49459	reviewed	UBE2A_HUMAN	Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)	UBE2A RAD6A	Homo sapiens (Human)	152	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. {ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:20061386}.		DNA repair [GO:0006281]; G2/M transition of mitotic cell cycle [GO:0000086]; postreplication repair [GO:0006301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; response to UV [GO:0009411]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromatin [GO:0000785]; cytosol [GO:0005829]; HULC complex [GO:0033503]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; histone ubiquitin ligase activity [GO:0140852]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	chromatin [GO:0000785]; cytosol [GO:0005829]; HULC complex [GO:0033503]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; histone ubiquitin ligase activity [GO:0140852]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; DNA repair [GO:0006281]; G2/M transition of mitotic cell cycle [GO:0000086]; postreplication repair [GO:0006301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; response to UV [GO:0009411]; ubiquitin-dependent protein catabolic process [GO:0006511]	
P49585	reviewed	PCY1A_HUMAN	Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A)	PCYT1A CTPCT PCYT1	Homo sapiens (Human)	367	FUNCTION: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:7918629}.		CDP-choline pathway [GO:0006657]; phosphatidylcholine biosynthetic process [GO:0006656]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycogen granule [GO:0042587]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]	calmodulin binding [GO:0005516]; choline-phosphate cytidylyltransferase activity [GO:0004105]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; phosphatidylcholine binding [GO:0031210]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycogen granule [GO:0042587]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; calmodulin binding [GO:0005516]; choline-phosphate cytidylyltransferase activity [GO:0004105]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; phosphatidylcholine binding [GO:0031210]; protein homodimerization activity [GO:0042803]; CDP-choline pathway [GO:0006657]; phosphatidylcholine biosynthetic process [GO:0006656]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P19836}. Membrane {ECO:0000250|UniProtKB:P19836}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19836}. Endoplasmic reticulum {ECO:0000269|PubMed:10480912}. Nucleus {ECO:0000269|PubMed:10480912}. Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form. {ECO:0000250|UniProtKB:P19836}.
P49588	reviewed	SYAC_HUMAN	Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Renal carcinoma antigen NY-REN-42)	AARS1 AARS	Homo sapiens (Human)	968	FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438). {ECO:0000255|HAMAP-Rule:MF_03133, ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438, ECO:0000269|PubMed:33909043}.		alanyl-tRNA aminoacylation [GO:0006419]; cerebellar Purkinje cell layer development [GO:0021680]; negative regulation of neuron apoptotic process [GO:0043524]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; regulation of cytoplasmic translational fidelity [GO:0140018]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]	alanine-tRNA ligase activity [GO:0004813]; amino acid binding [GO:0016597]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; Ser-tRNA(Ala) hydrolase activity [GO:0002196]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; alanine-tRNA ligase activity [GO:0004813]; amino acid binding [GO:0016597]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; Ser-tRNA(Ala) hydrolase activity [GO:0002196]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; alanyl-tRNA aminoacylation [GO:0006419]; cerebellar Purkinje cell layer development [GO:0021680]; negative regulation of neuron apoptotic process [GO:0043524]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; regulation of cytoplasmic translational fidelity [GO:0140018]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03133, ECO:0000269|PubMed:27911835}.
P49589	reviewed	SYCC_HUMAN	Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)	CARS1 CARS	Homo sapiens (Human)	748	FUNCTION: Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). {ECO:0000269|PubMed:11347887, ECO:0000269|PubMed:30824121}.	MISCELLANEOUS: [Isoform 2]: Found in 20% of the mRNAs. {ECO:0000305}.	cysteinyl-tRNA aminoacylation [GO:0006423]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; cysteine-tRNA ligase activity [GO:0004817]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; cysteine-tRNA ligase activity [GO:0004817]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; cysteinyl-tRNA aminoacylation [GO:0006423]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30824121}.
P49590	reviewed	SYHM_HUMAN	Histidine--tRNA ligase, mitochondrial (EC 6.1.1.21) (Histidine--tRNA ligase-like) (Histidyl-tRNA synthetase) (HisRS)	HARS2 HARSL HARSR HO3	Homo sapiens (Human)	506	FUNCTION: Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). {ECO:0000269|PubMed:21464306}.		histidyl-tRNA aminoacylation [GO:0006427]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; histidine-tRNA ligase activity [GO:0004821]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; histidine-tRNA ligase activity [GO:0004821]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; histidyl-tRNA aminoacylation [GO:0006427]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21464306}.
P49591	reviewed	SYSC_HUMAN	Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)	SARS1 SARS SERS	Homo sapiens (Human)	514	FUNCTION: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339, PubMed:34570399). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000). {ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848, ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229, ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817, ECO:0000269|PubMed:9431993}.		cytoplasmic translation [GO:0002181]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular endothelial growth factor production [GO:1904046]; selenocysteine incorporation [GO:0001514]; seryl-tRNA aminoacylation [GO:0006434]; translation [GO:0006412]; tRNA modification [GO:0006400]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; selenocysteine-tRNA ligase activity [GO:0098619]; serine-tRNA ligase activity [GO:0004828]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; selenocysteine-tRNA ligase activity [GO:0098619]; serine-tRNA ligase activity [GO:0004828]; tRNA binding [GO:0000049]; cytoplasmic translation [GO:0002181]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular endothelial growth factor production [GO:1904046]; selenocysteine incorporation [GO:0001514]; seryl-tRNA aminoacylation [GO:0006434]; translation [GO:0006412]; tRNA modification [GO:0006400]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817}. Nucleus {ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817}. Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus. {ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817}.
P49593	reviewed	PPM1F_HUMAN	Protein phosphatase 1F (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (Protein fem-2 homolog) (hFem-2)	PPM1F KIAA0015 POPX2	Homo sapiens (Human)	454	FUNCTION: Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.		cellular response to xenobiotic stimulus [GO:0071466]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of protein transport [GO:0051224]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of growth [GO:0045927]; positive regulation of stress fiber assembly [GO:0051496]; regulation of protein localization [GO:0032880]	cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cellular response to xenobiotic stimulus [GO:0071466]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of protein transport [GO:0051224]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of growth [GO:0045927]; positive regulation of stress fiber assembly [GO:0051496]; regulation of protein localization [GO:0032880]	
P49619	reviewed	DGKG_HUMAN	Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma)	DGKG DAGK3	Homo sapiens (Human)	791	FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity). Has no apparent specificity with regard to the acyl compositions of diacylglycerol (PubMed:8034597). Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity). {ECO:0000250|UniProtKB:Q91WG7, ECO:0000269|PubMed:8034597}.	MISCELLANEOUS: [Isoform 2]: May be inactive. {ECO:0000305}.	diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of protein kinase C signaling [GO:0090038]; neuron development [GO:0048666]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of dendrite development [GO:0050773]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289]; diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of protein kinase C signaling [GO:0090038]; neuron development [GO:0048666]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of dendrite development [GO:0050773]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8034597}. Cytoplasm, cytosol {ECO:0000269|PubMed:8034597}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P49620}.
P49638	reviewed	TTPA_HUMAN	Alpha-tocopherol transfer protein (Alpha-TTP)	TTPA TPP1	Homo sapiens (Human)	278	FUNCTION: Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity). {ECO:0000250, ECO:0000269|PubMed:7887897}.		embryonic placenta development [GO:0001892]; intermembrane lipid transfer [GO:0120009]; lipid metabolic process [GO:0006629]; negative regulation of establishment of blood-brain barrier [GO:0090212]; positive regulation of amyloid-beta clearance [GO:1900223]; response to toxic substance [GO:0009636]; vitamin E metabolic process [GO:0042360]; vitamin transport [GO:0051180]	cytosol [GO:0005829]; late endosome [GO:0005770]	lipid transfer activity [GO:0120013]; phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; vitamin E binding [GO:0008431]	cytosol [GO:0005829]; late endosome [GO:0005770]; lipid transfer activity [GO:0120013]; phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; vitamin E binding [GO:0008431]; embryonic placenta development [GO:0001892]; intermembrane lipid transfer [GO:0120009]; lipid metabolic process [GO:0006629]; negative regulation of establishment of blood-brain barrier [GO:0090212]; positive regulation of amyloid-beta clearance [GO:1900223]; response to toxic substance [GO:0009636]; vitamin E metabolic process [GO:0042360]; vitamin transport [GO:0051180]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7887897}.
P49639	reviewed	HXA1_HUMAN	Homeobox protein Hox-A1 (Homeobox protein Hox-1F)	HOXA1 HOX1F	Homo sapiens (Human)	335	FUNCTION: Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity). {ECO:0000250|UniProtKB:P09022, ECO:0000250|UniProtKB:Q90423, ECO:0000269|PubMed:16155570}.	MISCELLANEOUS: [Isoform 1]: Lacks the homeobox domain. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2]: Lacks the homeobox domain. {ECO:0000305}.	abducens nerve formation [GO:0021599]; anatomical structure morphogenesis [GO:0009653]; artery development [GO:0060840]; artery morphogenesis [GO:0048844]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; cognition [GO:0050890]; embryonic neurocranium morphogenesis [GO:0048702]; inner ear development [GO:0048839]; neuromuscular process [GO:0050905]; optokinetic behavior [GO:0007634]; outer ear morphogenesis [GO:0042473]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of behavior [GO:0050795]; regulation of transcription by RNA polymerase II [GO:0006357]; semicircular canal formation [GO:0060876]; sensory perception of sound [GO:0007605]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; abducens nerve formation [GO:0021599]; anatomical structure morphogenesis [GO:0009653]; artery development [GO:0060840]; artery morphogenesis [GO:0048844]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; cognition [GO:0050890]; embryonic neurocranium morphogenesis [GO:0048702]; inner ear development [GO:0048839]; neuromuscular process [GO:0050905]; optokinetic behavior [GO:0007634]; outer ear morphogenesis [GO:0042473]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of behavior [GO:0050795]; regulation of transcription by RNA polymerase II [GO:0006357]; semicircular canal formation [GO:0060876]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P09022}.
P49640	reviewed	EVX1_HUMAN	Homeobox even-skipped homolog protein 1 (EVX-1)	EVX1	Homo sapiens (Human)	407	FUNCTION: May play a role in the specification of neuronal cell types.		embryo development ending in birth or egg hatching [GO:0009792]; interneuron migration [GO:1904936]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord interneuron axon guidance [GO:0097377]	axon [GO:0030424]; chromatin [GO:0000785]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	axon [GO:0030424]; chromatin [GO:0000785]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; embryo development ending in birth or egg hatching [GO:0009792]; interneuron migration [GO:1904936]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord interneuron axon guidance [GO:0097377]	SUBCELLULAR LOCATION: Nucleus.
P49641	reviewed	MA2A2_HUMAN	Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)	MAN2A2 MANA2X	Homo sapiens (Human)	1150	FUNCTION: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491]	Golgi membrane [GO:0000139]	alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]; metal ion binding [GO:0046872]	Golgi membrane [GO:0000139]; alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]; metal ion binding [GO:0046872]; mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
P49642	reviewed	PRI1_HUMAN	DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49)	PRIM1	Homo sapiens (Human)	420	FUNCTION: Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (PubMed:9268648, PubMed:9705292, PubMed:17893144, PubMed:24043831, PubMed:26975377, PubMed:25550159, PubMed:31479243, PubMed:33060134). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Synthesizes 9-mer RNA primers (also known as the 'unit length' RNA primers). Incorporates only ribonucleotides in the presence of ribo- and deoxy-nucleotide triphosphates (rNTPs, dNTPs) (PubMed:26975377). Requires template thymine or cytidine to start the RNA primer synthesis, with an adenine or guanine at its 5'-end (PubMed:25550159, PubMed:26975377). Binds single stranded DNA (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000269|PubMed:17893144, ECO:0000269|PubMed:25550159, ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:33060134, ECO:0000269|PubMed:9268648, ECO:0000269|PubMed:9705292}.	MISCELLANEOUS: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity). {ECO:0000250}.	DNA replication initiation [GO:0006270]; DNA replication, synthesis of RNA primer [GO:0006269]	alpha DNA polymerase:primase complex [GO:0005658]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	DNA primase activity [GO:0003896]; magnesium ion binding [GO:0000287]; ribonucleotide binding [GO:0032553]; zinc ion binding [GO:0008270]	alpha DNA polymerase:primase complex [GO:0005658]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; DNA primase activity [GO:0003896]; magnesium ion binding [GO:0000287]; ribonucleotide binding [GO:0032553]; zinc ion binding [GO:0008270]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of RNA primer [GO:0006269]	
P49643	reviewed	PRI2_HUMAN	DNA primase large subunit (DNA primase 58 kDa subunit) (p58)	PRIM2 PRIM2A	Homo sapiens (Human)	509	FUNCTION: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:9705292, PubMed:17893144, PubMed:25550159, PubMed:26975377). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144, PubMed:25550159). Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase-to-polymerase switch. {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P33610, ECO:0000269|PubMed:17893144, ECO:0000269|PubMed:25550159, ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:9705292}.		DNA replication initiation [GO:0006270]; DNA replication, synthesis of RNA primer [GO:0006269]; positive regulation of DNA primase activity [GO:1903934]	alpha DNA polymerase:primase complex [GO:0005658]; nucleoplasm [GO:0005654]	4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA/RNA hybrid binding [GO:0071667]; metal ion binding [GO:0046872]	alpha DNA polymerase:primase complex [GO:0005658]; nucleoplasm [GO:0005654]; 4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA/RNA hybrid binding [GO:0071667]; metal ion binding [GO:0046872]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of RNA primer [GO:0006269]; positive regulation of DNA primase activity [GO:1903934]	
P49662	reviewed	CASP4_HUMAN	Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]	CASP4 ICH2	Homo sapiens (Human)	377	FUNCTION: Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:25119034, PubMed:26375003, PubMed:34671164, PubMed:32109412, PubMed:37001519). Also indirectly activates the NLRP3 and NLRP6 inflammasomes (PubMed:7797510, PubMed:23516580, PubMed:26375003, PubMed:32109412). Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS, GSDMD and IL18 (PubMed:7797510, PubMed:15326478, PubMed:23516580, PubMed:26375003, PubMed:28314590, PubMed:32109412). Effector of the non-canonical inflammasome independently of NLRP3 inflammasome and CASP1: the non-canonical inflammasome promotes pyroptosis through GSDMD cleavage without involving secretion of cytokine IL1B and IL18 (PubMed:25121752, PubMed:25119034, PubMed:26375003, PubMed:31268602, PubMed:32109412). In the non-canonical inflammasome, CASP4 is activated by direct binding to LPS without the need of an upstream sensor (PubMed:25121752, PubMed:25119034, PubMed:29520027). LPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD, followed by pyroptosis of infected cells and their extrusion into the gut lumen (PubMed:25121752, PubMed:25119034). Also indirectly promotes secretion of mature cytokines (IL1A, IL18 and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NLRP3 and NLRP6 inflammasomes (PubMed:26375003, PubMed:32109412). Involved in NLRP3-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation or cholera enterotoxin (PubMed:22246630, PubMed:23516580, PubMed:24879791, PubMed:25964352, PubMed:26173988, PubMed:26174085, PubMed:26508369). Involved in NLRP6 inflammasome-dependent activation in response to lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, which leads to CASP1 activation and IL1B and IL18 secretion (PubMed:33377178). Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). The non-canonical inflammasome is required for innate immunity to cytosolic, but not vacuolar, bacteria (By similarity). Plays a crucial role in the restriction of S.typhimurium replication in colonic epithelial cells during infection (PubMed:25121752, PubMed:25964352). Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752, PubMed:26375003, PubMed:25964352). May also act as an activator of adaptive immunity in dendritic cells, following activation by oxidized phospholipid 1-palmitoyl-2-arachidonoyl- sn-glycero-3-phosphorylcholine, an oxidized phospholipid (oxPAPC) (By similarity). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found in Alzheimer's patient brains (PubMed:15123740, PubMed:22246630, PubMed:23661706). Cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Catalyzes cleavage and maturation of IL18 (PubMed:15326478). In contrast, it does not directly process IL1B (PubMed:7743998, PubMed:7797592, PubMed:7797510). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). {ECO:0000250|UniProtKB:P70343, ECO:0000269|PubMed:15123740, ECO:0000269|PubMed:15326478, ECO:0000269|PubMed:22246630, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:23661706, ECO:0000269|PubMed:24879791, ECO:0000269|PubMed:25119034, ECO:0000269|PubMed:25121752, ECO:0000269|PubMed:25964352, ECO:0000269|PubMed:26173988, ECO:0000269|PubMed:26174085, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26508369, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:29520027, ECO:0000269|PubMed:31268602, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:33377178, ECO:0000269|PubMed:34671164, ECO:0000269|PubMed:37001519, ECO:0000269|PubMed:7743998, ECO:0000269|PubMed:7797510, ECO:0000269|PubMed:7797592}.; FUNCTION: (Microbial infection) In response to the Td92 surface protein of the periodontal pathogen T.denticola, activated by cathepsin CTSG which leads to production and secretion of IL1A and pyroptosis of gingival fibroblasts. {ECO:0000269|PubMed:29077095}.	MISCELLANEOUS: [Isoform 3]: May be due to competing acceptor splice site. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	apoptotic process [GO:0006915]; cellular response to amyloid-beta [GO:1904646]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; non-canonical inflammasome complex assembly [GO:0160075]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-18-mediated signaling pathway [GO:2000494]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein autoprocessing [GO:0016540]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]	canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; non-canonical inflammasome complex [GO:0160074]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	CARD domain binding [GO:0050700]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; lipopolysaccharide binding [GO:0001530]	canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; non-canonical inflammasome complex [GO:0160074]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; CARD domain binding [GO:0050700]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; lipopolysaccharide binding [GO:0001530]; apoptotic process [GO:0006915]; cellular response to amyloid-beta [GO:1904646]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; non-canonical inflammasome complex assembly [GO:0160075]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-18-mediated signaling pathway [GO:2000494]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein autoprocessing [GO:0016540]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23661706}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15123740, ECO:0000269|PubMed:23661706}; Peripheral membrane protein {ECO:0000269|PubMed:23661706}; Cytoplasmic side {ECO:0000269|PubMed:23661706}. Mitochondrion {ECO:0000269|PubMed:15123740, ECO:0000269|PubMed:23661706}. Inflammasome {ECO:0000269|PubMed:25119034, ECO:0000269|PubMed:26508369}. Secreted {ECO:0000269|PubMed:22246630}. Note=Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630). {ECO:0000269|PubMed:15123740, ECO:0000269|PubMed:22246630}.
P49674	reviewed	KC1E_HUMAN	Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)	CSNK1E	Homo sapiens (Human)	416	FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). {ECO:0000250|UniProtKB:Q9JMK2, ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191, ECO:0000305|PubMed:7797465}.		canonical Wnt signaling pathway [GO:0060070]; cellular response to nerve growth factor stimulus [GO:1990090]; circadian behavior [GO:0048512]; circadian regulation of gene expression [GO:0032922]; DNA repair [GO:0006281]; endocytosis [GO:0006897]; negative regulation of protein binding [GO:0032091]; negative regulation of Wnt signaling pathway [GO:0030178]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation [GO:1905426]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of protein localization [GO:0032880]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; canonical Wnt signaling pathway [GO:0060070]; cellular response to nerve growth factor stimulus [GO:1990090]; circadian behavior [GO:0048512]; circadian regulation of gene expression [GO:0032922]; DNA repair [GO:0006281]; endocytosis [GO:0006897]; negative regulation of protein binding [GO:0032091]; negative regulation of Wnt signaling pathway [GO:0030178]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation [GO:1905426]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of protein localization [GO:0032880]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
P49675	reviewed	STAR_HUMAN	Steroidogenic acute regulatory protein, mitochondrial (StAR) (START domain-containing protein 1) (StARD1)	STAR STARD1	Homo sapiens (Human)	285	FUNCTION: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. {ECO:0000269|PubMed:7761400, ECO:0000269|PubMed:7892608, ECO:0000269|PubMed:8948562}.		cellular lipid metabolic process [GO:0044255]; cholesterol metabolic process [GO:0008203]; glucocorticoid metabolic process [GO:0008211]; intracellular cholesterol transport [GO:0032367]; positive regulation of bile acid biosynthetic process [GO:0070859]; regulation of steroid biosynthetic process [GO:0050810]; steroid biosynthetic process [GO:0006694]	mitochondrial intermembrane space [GO:0005758]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]	mitochondrial intermembrane space [GO:0005758]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; cellular lipid metabolic process [GO:0044255]; cholesterol metabolic process [GO:0008203]; glucocorticoid metabolic process [GO:0008211]; intracellular cholesterol transport [GO:0032367]; positive regulation of bile acid biosynthetic process [GO:0070859]; regulation of steroid biosynthetic process [GO:0050810]; steroid biosynthetic process [GO:0006694]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P51557}.
P49682	reviewed	CXCR3_HUMAN	C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)	CXCR3 GPR9	Homo sapiens (Human)	368	FUNCTION: [Isoform 1]: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. {ECO:0000269|PubMed:12782716}.; FUNCTION: [Isoform 2]: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. {ECO:0000269|PubMed:12782716}.; FUNCTION: [Isoform 3]: Mediates the activity of CXCL11.	MISCELLANEOUS: [Isoform 3]: Due to exon skipping. {ECO:0000305}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell adhesion [GO:0030155]; regulation of leukocyte migration [GO:0002685]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine binding [GO:0019958]; C-X-C chemokine receptor activity [GO:0016494]; chemokine binding [GO:0019956]; chemokine receptor activity [GO:0004950]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine binding [GO:0019958]; C-X-C chemokine receptor activity [GO:0016494]; chemokine binding [GO:0019956]; chemokine receptor activity [GO:0004950]; signaling receptor activity [GO:0038023]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell adhesion [GO:0030155]; regulation of leukocyte migration [GO:0002685]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12782716}; Multi-pass membrane protein {ECO:0000269|PubMed:12782716}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:12782716}; Multi-pass membrane protein {ECO:0000269|PubMed:12782716}.
P49683	reviewed	PRLHR_HUMAN	Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G-protein coupled receptor 10) (hGR3)	PRLHR GPR10 GR3	Homo sapiens (Human)	370	FUNCTION: Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.		feeding behavior [GO:0007631]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone metabolic process [GO:0042445]	cilium [GO:0005929]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]	cilium [GO:0005929]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]; feeding behavior [GO:0007631]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone metabolic process [GO:0042445]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P49685	reviewed	GPR15_HUMAN	G-protein coupled receptor 15 (Brother of Bonzo) (BoB)	GPR15	Homo sapiens (Human)	360	FUNCTION: Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.		angiogenesis [GO:0001525]; G protein-coupled receptor signaling pathway [GO:0007186]; T cell migration [GO:0072678]; viral entry into host cell [GO:0046718]	cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886]	coreceptor activity [GO:0015026]; G protein-coupled receptor activity [GO:0004930]; virus receptor activity [GO:0001618]	cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886]; coreceptor activity [GO:0015026]; G protein-coupled receptor activity [GO:0004930]; virus receptor activity [GO:0001618]; angiogenesis [GO:0001525]; G protein-coupled receptor signaling pathway [GO:0007186]; T cell migration [GO:0072678]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P49703	reviewed	ARL4D_HUMAN	ADP-ribosylation factor-like protein 4D (ADP-ribosylation factor-like protein 4L)	ARL4D ARF4L	Homo sapiens (Human)	201	FUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. {ECO:0000269|PubMed:17398095}.		intracellular protein transport [GO:0006886]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:17398095}. Nucleus {ECO:0000269|PubMed:17398095}. Cytoplasm {ECO:0000269|PubMed:17398095}.
P49711	reviewed	CTCF_HUMAN	Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog)	CTCF	Homo sapiens (Human)	727	FUNCTION: Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays an important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X- inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19. Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640). {ECO:0000269|PubMed:11743158, ECO:0000269|PubMed:16815976, ECO:0000269|PubMed:17827499, ECO:0000269|PubMed:18347100, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18550811, ECO:0000269|PubMed:18654629, ECO:0000269|PubMed:19322193, ECO:0000269|PubMed:26321640, ECO:0000269|PubMed:8649389, ECO:0000269|PubMed:9591631}.	MISCELLANEOUS: More than 13'00 CTCF-binding sites in potential insulators were identified in the human genome.	chromatin looping [GO:0140588]; chromosome segregation [GO:0007059]; DNA methylation [GO:0006306]; epigenetic regulation of gene expression [GO:0040029]; genomic imprinting [GO:0071514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression via CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; protein localization to chromosome, centromeric region [GO:0071459]; regulation of centromeric sister chromatid cohesion [GO:0070602]; regulation of gene expression by genomic imprinting [GO:0006349]	chromosome, centromeric region [GO:0000775]; condensed chromosome [GO:0000793]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin insulator sequence binding [GO:0043035]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]	chromosome, centromeric region [GO:0000775]; condensed chromosome [GO:0000793]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin insulator sequence binding [GO:0043035]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]; chromatin looping [GO:0140588]; chromosome segregation [GO:0007059]; DNA methylation [GO:0006306]; epigenetic regulation of gene expression [GO:0040029]; genomic imprinting [GO:0071514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression via CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; protein localization to chromosome, centromeric region [GO:0071459]; regulation of centromeric sister chromatid cohesion [GO:0070602]; regulation of gene expression by genomic imprinting [GO:0006349]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:28319062}. Chromosome {ECO:0000269|PubMed:26321640}. Chromosome, centromere {ECO:0000269|PubMed:26321640}. Note=May translocate to the nucleolus upon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with the H19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase.
P49715	reviewed	CEBPA_HUMAN	CCAAT/enhancer-binding protein alpha (C/EBP alpha)	CEBPA CEBP	Homo sapiens (Human)	358	FUNCTION: Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:11242107, ECO:0000269|PubMed:14660596}.; FUNCTION: [Isoform 3]: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation (PubMed:14660596). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:14660596}.; FUNCTION: [Isoform 4]: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation. {ECO:0000269|PubMed:20075868}.		brown fat cell differentiation [GO:0050873]; cellular response to lithium ion [GO:0071285]; cellular response to organic cyclic compound [GO:0071407]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol metabolic process [GO:0008203]; cytokine-mediated signaling pathway [GO:0019221]; DNA-templated transcription [GO:0006351]; embryonic placenta development [GO:0001892]; epithelial cell maturation [GO:0002070]; fat cell differentiation [GO:0045444]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; granulocyte differentiation [GO:0030851]; hematopoietic stem cell proliferation [GO:0071425]; inner ear development [GO:0048839]; integrated stress response signaling [GO:0140467]; interleukin-6-mediated signaling pathway [GO:0070102]; lipid homeostasis [GO:0055088]; liver development [GO:0001889]; lung development [GO:0030324]; macrophage differentiation [GO:0030225]; mitochondrion organization [GO:0007005]; myeloid cell differentiation [GO:0030099]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hematopoietic stem cell proliferation [GO:1902034]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage activation [GO:0043032]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase I [GO:0006360]; urea cycle [GO:0000050]; white fat cell differentiation [GO:0050872]	C/EBP complex [GO:1990647]; CHOP-C/EBP complex [GO:0036488]; chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein homodimerization activity [GO:0042803]; RNA polymerase I transcription regulatory region sequence-specific DNA binding [GO:0001163]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]	C/EBP complex [GO:1990647]; CHOP-C/EBP complex [GO:0036488]; chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein homodimerization activity [GO:0042803]; RNA polymerase I transcription regulatory region sequence-specific DNA binding [GO:0001163]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]; brown fat cell differentiation [GO:0050873]; cellular response to lithium ion [GO:0071285]; cellular response to organic cyclic compound [GO:0071407]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol metabolic process [GO:0008203]; cytokine-mediated signaling pathway [GO:0019221]; DNA-templated transcription [GO:0006351]; embryonic placenta development [GO:0001892]; epithelial cell maturation [GO:0002070]; fat cell differentiation [GO:0045444]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; granulocyte differentiation [GO:0030851]; hematopoietic stem cell proliferation [GO:0071425]; inner ear development [GO:0048839]; integrated stress response signaling [GO:0140467]; interleukin-6-mediated signaling pathway [GO:0070102]; lipid homeostasis [GO:0055088]; liver development [GO:0001889]; lung development [GO:0030324]; macrophage differentiation [GO:0030225]; mitochondrion organization [GO:0007005]; myeloid cell differentiation [GO:0030099]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hematopoietic stem cell proliferation [GO:1902034]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage activation [GO:0043032]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase I [GO:0006360]; urea cycle [GO:0000050]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11242107}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleolus {ECO:0000269|PubMed:20075868}.
P49716	reviewed	CEBPD_HUMAN	CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF-IL6-beta) (NF-IL6-beta)	CEBPD	Homo sapiens (Human)	269	FUNCTION: Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402). {ECO:0000269|PubMed:1741402}.		fat cell differentiation [GO:0045444]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear development [GO:0048839]; integrated stress response signaling [GO:0140467]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of cell differentiation [GO:0045595]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; fat cell differentiation [GO:0045444]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear development [GO:0048839]; integrated stress response signaling [GO:0140467]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of cell differentiation [GO:0045595]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:16397300}.
P49720	reviewed	PSB3_HUMAN	Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)	PSMB3	Homo sapiens (Human)	205	FUNCTION: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
P49721	reviewed	PSB2_HUMAN	Proteasome subunit beta type-2 (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I)	PSMB2	Homo sapiens (Human)	201	FUNCTION: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
P49736	reviewed	MCM2_HUMAN	DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)	MCM2 BM28 CCNL1 CDCL1 KIAA0030	Homo sapiens (Human)	904	FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}.	MISCELLANEOUS: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.	apoptotic process [GO:0006915]; cellular response to interleukin-4 [GO:0071353]; cochlea development [GO:0090102]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; nucleosome assembly [GO:0006334]; regulation of DNA-templated DNA replication initiation [GO:0030174]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; cytoplasm [GO:0005737]; MCM complex [GO:0042555]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA replication origin binding [GO:0003688]; enzyme binding [GO:0019899]; helicase activity [GO:0004386]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; cytoplasm [GO:0005737]; MCM complex [GO:0042555]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA replication origin binding [GO:0003688]; enzyme binding [GO:0019899]; helicase activity [GO:0004386]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; apoptotic process [GO:0006915]; cellular response to interleukin-4 [GO:0071353]; cochlea development [GO:0090102]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; nucleosome assembly [GO:0006334]; regulation of DNA-templated DNA replication initiation [GO:0030174]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8175912}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000250|UniProtKB:P55861}.
P49746	reviewed	TSP3_HUMAN	Thrombospondin-3	THBS3 TSP3	Homo sapiens (Human)	956	FUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.		bone trabecula formation [GO:0060346]; cell-matrix adhesion [GO:0007160]; growth plate cartilage development [GO:0003417]; ossification involved in bone maturation [GO:0043931]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]	calcium ion binding [GO:0005509]; heparin binding [GO:0008201]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; bone trabecula formation [GO:0060346]; cell-matrix adhesion [GO:0007160]; growth plate cartilage development [GO:0003417]; ossification involved in bone maturation [GO:0043931]	
P49747	reviewed	COMP_HUMAN	Cartilage oligomeric matrix protein (COMP) (Thrombospondin-5) (TSP5)	COMP	Homo sapiens (Human)	757	FUNCTION: Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors (PubMed:16542502, PubMed:16051604). Could play a role in the pathogenesis of osteoarthritis (PubMed:16542502). Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (PubMed:17993464). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). {ECO:0000250|UniProtKB:P35444, ECO:0000269|PubMed:16051604, ECO:0000269|PubMed:16542502, ECO:0000269|PubMed:17993464}.		animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; BMP signaling pathway [GO:0030509]; bone mineralization [GO:0030282]; cartilage homeostasis [GO:1990079]; cellular senescence [GO:0090398]; chondrocyte development [GO:0002063]; chondrocyte proliferation [GO:0035988]; collagen fibril organization [GO:0030199]; growth plate cartilage development [GO:0003417]; limb development [GO:0060173]; multicellular organism growth [GO:0035264]; musculoskeletal movement [GO:0050881]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hemostasis [GO:1900047]; platelet aggregation [GO:0070527]; positive regulation of chondrocyte proliferation [GO:1902732]; protein homooligomerization [GO:0051260]; protein processing [GO:0016485]; protein secretion [GO:0009306]; regulation of bone mineralization [GO:0030500]; regulation of gene expression [GO:0010468]; response to unfolded protein [GO:0006986]; skeletal system development [GO:0001501]; skin development [GO:0043588]; tendon development [GO:0035989]; vascular associated smooth muscle cell development [GO:0097084]; vascular associated smooth muscle contraction [GO:0014829]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]	BMP binding [GO:0036122]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; protease binding [GO:0002020]; proteoglycan binding [GO:0043394]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]; BMP binding [GO:0036122]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; protease binding [GO:0002020]; proteoglycan binding [GO:0043394]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; BMP signaling pathway [GO:0030509]; bone mineralization [GO:0030282]; cartilage homeostasis [GO:1990079]; cellular senescence [GO:0090398]; chondrocyte development [GO:0002063]; chondrocyte proliferation [GO:0035988]; collagen fibril organization [GO:0030199]; growth plate cartilage development [GO:0003417]; limb development [GO:0060173]; multicellular organism growth [GO:0035264]; musculoskeletal movement [GO:0050881]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hemostasis [GO:1900047]; platelet aggregation [GO:0070527]; positive regulation of chondrocyte proliferation [GO:1902732]; protein homooligomerization [GO:0051260]; protein processing [GO:0016485]; protein secretion [GO:0009306]; regulation of bone mineralization [GO:0030500]; regulation of gene expression [GO:0010468]; response to unfolded protein [GO:0006986]; skeletal system development [GO:0001501]; skin development [GO:0043588]; tendon development [GO:0035989]; vascular associated smooth muscle cell development [GO:0097084]; vascular associated smooth muscle contraction [GO:0014829]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:32686688}.
P49748	reviewed	ACADV_HUMAN	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9)	ACADVL VLCAD	Homo sapiens (Human)	655	FUNCTION: Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:7668252, PubMed:9461620, PubMed:18227065, PubMed:9839948, PubMed:9599005). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:7668252, PubMed:9461620, PubMed:18227065, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948). {ECO:0000269|PubMed:18227065, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:7668252, ECO:0000269|PubMed:9461620, ECO:0000269|PubMed:9599005, ECO:0000269|PubMed:9839948}.		energy derivation by oxidation of organic compounds [GO:0015980]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of fatty acid oxidation [GO:0046322]; regulation of cholesterol metabolic process [GO:0090181]; response to cold [GO:0009409]; temperature homeostasis [GO:0001659]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	acyl-CoA dehydrogenase activity [GO:0003995]; fatty-acyl-CoA binding [GO:0000062]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; long-chain-acyl-CoA dehydrogenase activity [GO:0004466]; very-long-chain-acyl-CoA dehydrogenase activity [GO:0017099]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; acyl-CoA dehydrogenase activity [GO:0003995]; fatty-acyl-CoA binding [GO:0000062]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; long-chain-acyl-CoA dehydrogenase activity [GO:0004466]; very-long-chain-acyl-CoA dehydrogenase activity [GO:0017099]; energy derivation by oxidation of organic compounds [GO:0015980]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of fatty acid oxidation [GO:0046322]; regulation of cholesterol metabolic process [GO:0090181]; response to cold [GO:0009409]; temperature homeostasis [GO:0001659]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:9461620, ECO:0000269|PubMed:9599005}; Peripheral membrane protein {ECO:0000269|PubMed:9599005}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion inner membrane {ECO:0000269|PubMed:17374501}; Peripheral membrane protein {ECO:0000269|PubMed:17374501}.
P49753	reviewed	ACOT2_HUMAN	Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (Acyl-coenzyme A thioester hydrolase 2a) (CTE-Ia) (Long-chain acyl-CoA thioesterase 2) (ZAP128)	ACOT2 PTE2 PTE2A	Homo sapiens (Human)	483	FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16940157, PubMed:10944470). Displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:16940157, PubMed:10944470). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). {ECO:0000250|UniProtKB:Q9QYR9, ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:16940157}.		acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid metabolic process [GO:0001676]; very long-chain fatty acid metabolic process [GO:0000038]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]	acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid metabolic process [GO:0001676]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16940157}.
P49754	reviewed	VPS41_HUMAN	Vacuolar protein sorting-associated protein 41 homolog (S53)	VPS41	Homo sapiens (Human)	854	FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085, PubMed:33851776). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847, PubMed:21802320). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660). {ECO:0000250|UniProtKB:D3ZVH6, ECO:0000269|PubMed:21802320, ECO:0000269|PubMed:23167963, ECO:0000269|PubMed:23322049, ECO:0000269|PubMed:25445562, ECO:0000269|PubMed:25783203, ECO:0000269|PubMed:25908847, ECO:0000269|PubMed:33851776, ECO:0000269|PubMed:9159129, ECO:0000305|PubMed:23167963, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:24210660, ECO:0000305|PubMed:25445562}.	MISCELLANEOUS: Protective against both alpha-synuclein and neurotoxic-mediated injury in invertebrate and cellular models of Parkinson's disease (PD); the function requires the AP-3 adapter complex and the HOPS complex. {ECO:0000269|PubMed:19850127, ECO:0000269|PubMed:22323726}.	cellular response to starvation [GO:0009267]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; Golgi vesicle transport [GO:0048193]; late endosome to lysosome transport [GO:1902774]; macroautophagy [GO:0016236]; protein targeting to vacuole [GO:0006623]; regulation of SNARE complex assembly [GO:0035542]; vesicle-mediated transport [GO:0016192]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal HOPS complex [GO:1902501]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal HOPS complex [GO:1902501]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; cellular response to starvation [GO:0009267]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; Golgi vesicle transport [GO:0048193]; late endosome to lysosome transport [GO:1902774]; macroautophagy [GO:0016236]; protein targeting to vacuole [GO:0006623]; regulation of SNARE complex assembly [GO:0035542]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:21411634, ECO:0000269|PubMed:23322049, ECO:0000269|PubMed:25445562}; Peripheral membrane protein {ECO:0000269|PubMed:23167963, ECO:0000269|PubMed:25445562}. Late endosome membrane {ECO:0000269|PubMed:23322049, ECO:0000269|PubMed:33422265}; Peripheral membrane protein {ECO:0000269|PubMed:23167963, ECO:0000269|PubMed:25445562}. Early endosome membrane {ECO:0000269|PubMed:21411634}; Peripheral membrane protein {ECO:0000269|PubMed:23167963, ECO:0000269|PubMed:25445562}. Lysosome membrane {ECO:0000269|PubMed:21802320, ECO:0000269|PubMed:23322049, ECO:0000269|PubMed:33422265, ECO:0000269|PubMed:33851776}; Peripheral membrane protein {ECO:0000269|PubMed:23167963}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23322049}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:21411634}. Cytoplasm, cytosol {ECO:0000269|PubMed:23167963}.; SUBCELLULAR LOCATION: Note=(Microbial infection) Sequestrated at the late endosome by SARS coronavirus-2/SARS-CoV-2 ORF3A protein. {ECO:0000269|PubMed:33422265}.
P49755	reviewed	TMEDA_HUMAN	Transmembrane emp24 domain-containing protein 10 (Protein TMED10) (21 kDa transmembrane-trafficking protein) (S31I125) (S31III125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta)	TMED10 TMP21	Homo sapiens (Human)	219	FUNCTION: Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi (PubMed:10052452, PubMed:11726511, PubMed:16641999, PubMed:17288597, PubMed:19296914, PubMed:20427317, PubMed:21219331, PubMed:27569046). The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes (PubMed:10052452). Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side (PubMed:20427317, PubMed:27569046). Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles (PubMed:10052452, PubMed:10852829, PubMed:12237308). In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER (PubMed:20427317, PubMed:27569046). Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5 (By similarity). In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment (PubMed:11726511). Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma-secretase activity) (PubMed:17288597). Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2 (By similarity). On Golgi membranes, acts as primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation (PubMed:11726511). Increases coatomer-dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus (PubMed:19296914). Involved in the exocytic trafficking of G protein-coupled receptors F2LR1/PAR2 (trypsin and tryspin-like enzyme receptor), OPRM1 (opioid receptor) and P2RY4 (UTD and UDP receptor) from the Golgi to the plasma membrane, thus contributing to receptor resensitization (PubMed:21219331). In addition to its cargo receptor activity, may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC (PubMed:32272059). Involved in the translocation into ERGIC, the vesicle entry and the secretion of leaderless cargos (lacking the secretion signal sequence), including the mature form of interleukin 1/IL-1 family members, the alpha-crystallin B chain HSPB5, the carbohydrate-binding proteins galectin-1/LGALS1 and galectin-3/LGALS3, the microtubule-associated protein Tau/MAPT, and the annexin A1/ANXA1; the translocation process is dependent on cargo protein unfolding and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9 (PubMed:32272059). Could also associates with the presenilin-dependent gamma-secretase complex in order to regulate gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40/Abeta40 (PubMed:16641999). {ECO:0000250|UniProtKB:Q28735, ECO:0000250|UniProtKB:Q63584, ECO:0000269|PubMed:10052452, ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:11726511, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:16641999, ECO:0000269|PubMed:17288597, ECO:0000269|PubMed:19296914, ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331, ECO:0000269|PubMed:27569046, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:10052452}.	MISCELLANEOUS: Ectopic expression of TMED10 alone does not result in its proper cis-Golgi network localization (PubMed:10852829). Interaction of TMED10 with TMED2 is both necessary and sufficient for transport of the couple to the cis-Golgi network, and TMED3 and/or TMED9 contribute to facilitating the process (PubMed:10852829). {ECO:0000269|PubMed:10852829}.	COPI coating of Golgi vesicle [GO:0048205]; COPI-coated vesicle budding [GO:0035964]; COPII vesicle coating [GO:0048208]; cytosol to ERGIC protein transport [GO:0106273]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of protein secretion [GO:0050714]; protein localization to ERGIC [GO:0106272]; regulated exocytosis [GO:0045055]; regulation of amyloid-beta formation [GO:1902003]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle cargo loading [GO:0035459]; vesicle targeting, to, from or within Golgi [GO:0048199]	cis-Golgi network [GO:0005801]; COPI-coated vesicle [GO:0030137]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133]; zymogen granule membrane [GO:0042589]	protein transmembrane transporter activity [GO:0008320]; syntaxin binding [GO:0019905]	cis-Golgi network [GO:0005801]; COPI-coated vesicle [GO:0030137]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133]; zymogen granule membrane [GO:0042589]; protein transmembrane transporter activity [GO:0008320]; syntaxin binding [GO:0019905]; COPI coating of Golgi vesicle [GO:0048205]; COPI-coated vesicle budding [GO:0035964]; COPII vesicle coating [GO:0048208]; cytosol to ERGIC protein transport [GO:0106273]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of protein secretion [GO:0050714]; protein localization to ERGIC [GO:0106272]; regulated exocytosis [GO:0045055]; regulation of amyloid-beta formation [GO:1902003]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle cargo loading [GO:0035459]; vesicle targeting, to, from or within Golgi [GO:0048199]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:9472029}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:9382861}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:21219331, ECO:0000269|PubMed:9382861, ECO:0000269|PubMed:9472029}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:9382861}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q63584}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q63584}; Single-pass type I membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.
P49756	reviewed	RBM25_HUMAN	RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7)	RBM25 RNPC7	Homo sapiens (Human)	843	FUNCTION: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle. Cytoplasm. Note=Colocalizes predominantly, with SFRS2 and LUC7L3 splicing factors, in nuclear speckles. Cytoplasmic localization is faint.
P49757	reviewed	NUMB_HUMAN	Protein numb homolog (h-Numb) (Protein S171)	NUMB C14orf41	Homo sapiens (Human)	651	FUNCTION: Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}.		adherens junction organization [GO:0034332]; axonogenesis [GO:0007409]; lateral ventricle development [GO:0021670]; negative regulation of protein localization to plasma membrane [GO:1903077]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of cell migration [GO:0030335]; positive regulation of neurogenesis [GO:0050769]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]	apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]	alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]	apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; adherens junction organization [GO:0034332]; axonogenesis [GO:0007409]; lateral ventricle development [GO:0021670]; negative regulation of protein localization to plasma membrane [GO:1903077]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of cell migration [GO:0030335]; positive regulation of neurogenesis [GO:0050769]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18657069}; Peripheral membrane protein {ECO:0000305|PubMed:18657069}; Cytoplasmic side {ECO:0000305|PubMed:18657069}. Endosome membrane {ECO:0000269|PubMed:18657069}; Peripheral membrane protein {ECO:0000305|PubMed:18657069}; Cytoplasmic side {ECO:0000305|PubMed:18657069}. Note=Localizes to perinuclear endosomes in an AAK1-dependent manner. {ECO:0000269|PubMed:18657069}.
P49758	reviewed	RGS6_HUMAN	Regulator of G-protein signaling 6 (RGS6) (S914)	RGS6	Homo sapiens (Human)	472	FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). {ECO:0000269|PubMed:10521509}.		G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12761221}. Cytoplasm, cytosol {ECO:0000269|PubMed:10521509}. Membrane {ECO:0000269|PubMed:10521509}; Peripheral membrane protein {ECO:0000269|PubMed:10521509}. Nucleus {ECO:0000269|PubMed:12761221}. Cell membrane {ECO:0000250|UniProtKB:Q9Z2H2}. Note=Interaction with GNB5 mediates translocation to the nucleus. {ECO:0000269|PubMed:12761221}.
P49759	reviewed	CLK1_HUMAN	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)	CLK1 CLK	Homo sapiens (Human)	484	FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:10480872, PubMed:19168442). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (PubMed:19168442). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442}.	MISCELLANEOUS: [Isoform 2]: Lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	phosphorylation [GO:0016310]; regulation of RNA splicing [GO:0043484]	nucleus [GO:0005634]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	nucleus [GO:0005634]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; phosphorylation [GO:0016310]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P22518}.
P49760	reviewed	CLK2_HUMAN	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)	CLK2	Homo sapiens (Human)	499	FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}.	MISCELLANEOUS: [Isoform 2]: Lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	negative regulation of gluconeogenesis [GO:0045721]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of RNA splicing [GO:0043484]; response to ionizing radiation [GO:0010212]	nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; negative regulation of gluconeogenesis [GO:0045721]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of RNA splicing [GO:0043484]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28289210}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:9637771}. Nucleus speckle {ECO:0000269|PubMed:9637771}. Note=Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. {ECO:0000250|UniProtKB:O35491}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus speckle {ECO:0000269|PubMed:9637771}. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. {ECO:0000269|PubMed:9637771}.
P49761	reviewed	CLK3_HUMAN	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)	CLK3	Homo sapiens (Human)	638	FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:9637771}.	MISCELLANEOUS: [Isoform 2]: Lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	protein phosphorylation [GO:0006468]; regulation of RNA splicing [GO:0043484]	acrosomal vesicle [GO:0001669]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; RNA binding [GO:0003723]	acrosomal vesicle [GO:0001669]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; RNA binding [GO:0003723]; protein phosphorylation [GO:0006468]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.
P49763	reviewed	PLGF_HUMAN	Placenta growth factor (PlGF)	PGF PGFL PLGF	Homo sapiens (Human)	221	FUNCTION: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. {ECO:0000269|PubMed:21215706}.		cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; induction of positive chemotaxis [GO:0050930]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of protein phosphorylation [GO:0001934]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]	chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; vascular endothelial growth factor receptor binding [GO:0005172]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; vascular endothelial growth factor receptor binding [GO:0005172]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; induction of positive chemotaxis [GO:0050930]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of protein phosphorylation [GO:0001934]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]	SUBCELLULAR LOCATION: Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
P49765	reviewed	VEGFB_HUMAN	Vascular endothelial growth factor B (VEGF-B) (VEGF-related factor) (VRF)	VEGFB VRF	Homo sapiens (Human)	207	FUNCTION: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.		cardiac muscle contraction [GO:0060048]; coronary vasculature development [GO:0060976]; induction of positive chemotaxis [GO:0050930]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of vascular wound healing [GO:0035470]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]	chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; vascular endothelial growth factor receptor 1 binding [GO:0043183]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; cardiac muscle contraction [GO:0060048]; coronary vasculature development [GO:0060976]; induction of positive chemotaxis [GO:0050930]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of vascular wound healing [GO:0035470]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]	SUBCELLULAR LOCATION: Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
P49767	reviewed	VEGFC_HUMAN	Vascular endothelial growth factor C (VEGF-C) (Flt4 ligand) (Flt4-L) (Vascular endothelial growth factor-related protein) (VRP)	VEGFC	Homo sapiens (Human)	419	FUNCTION: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. {ECO:0000269|PubMed:20145116}.		animal organ morphogenesis [GO:0009887]; cellular response to leukemia inhibitory factor [GO:1990830]; glial cell proliferation [GO:0014009]; induction of positive chemotaxis [GO:0050930]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of blood pressure [GO:0045776]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of lymphangiogenesis [GO:1901492]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate-dependent cell migration [GO:0006929]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]	chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; vascular endothelial growth factor receptor 3 binding [GO:0043185]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; vascular endothelial growth factor receptor 3 binding [GO:0043185]; animal organ morphogenesis [GO:0009887]; cellular response to leukemia inhibitory factor [GO:1990830]; glial cell proliferation [GO:0014009]; induction of positive chemotaxis [GO:0050930]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of blood pressure [GO:0045776]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of lymphangiogenesis [GO:1901492]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate-dependent cell migration [GO:0006929]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]	SUBCELLULAR LOCATION: Secreted.
P49768	reviewed	PSN1_HUMAN	Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]	PSEN1 AD3 PS1 PSNL1	Homo sapiens (Human)	467	FUNCTION: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15274632, PubMed:10545183, PubMed:10593990, PubMed:10206644, PubMed:10899933, PubMed:10811883, PubMed:12679784, PubMed:12740439, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874, PubMed:28269784, PubMed:20460383). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:9738936, PubMed:10593990, PubMed:10899933, PubMed:10811883). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:9738936, PubMed:11953314). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:25394380, PubMed:16959576). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15004326, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:20460383, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25394380, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:28269784, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000269|PubMed:9738936}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; amyloid-beta metabolic process [GO:0050435]; apoptotic signaling pathway [GO:0097190]; astrocyte activation [GO:0048143]; astrocyte activation involved in immune response [GO:0002265]; autophagosome assembly [GO:0000045]; blood vessel development [GO:0001568]; brain morphogenesis [GO:0048854]; Cajal-Retzius cell differentiation [GO:0021870]; calcium ion transport [GO:0006816]; cell fate specification [GO:0001708]; cell-cell adhesion [GO:0098609]; cellular response to amyloid-beta [GO:1904646]; cerebellum development [GO:0021549]; cerebral cortex cell migration [GO:0021795]; choline transport [GO:0015871]; DNA damage response [GO:0006974]; dorsal/ventral neural tube patterning [GO:0021904]; embryonic limb morphogenesis [GO:0030326]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial cell proliferation [GO:0050673]; heart looping [GO:0001947]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular signal transduction [GO:0035556]; L-glutamate import across plasma membrane [GO:0098712]; learning or memory [GO:0007611]; locomotion [GO:0040011]; membrane protein ectodomain proteolysis [GO:0006509]; memory [GO:0007613]; mitochondrial transport [GO:0006839]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of axonogenesis [GO:0050771]; negative regulation of core promoter binding [GO:1904797]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural retina development [GO:0003407]; neuron apoptotic process [GO:0051402]; neuron cellular homeostasis [GO:0070050]; neuron development [GO:0048666]; neuron migration [GO:0001764]; neuron projection maintenance [GO:1990535]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of apoptotic process [GO:0043065]; positive regulation of catalytic activity [GO:0043085]; positive regulation of coagulation [GO:0050820]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of L-glutamate import across plasma membrane [GO:0002038]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor recycling [GO:0001921]; positive regulation of tumor necrosis factor production [GO:0032760]; post-embryonic development [GO:0009791]; protein catabolic process at postsynapse [GO:0140249]; protein processing [GO:0016485]; protein transport [GO:0015031]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of gene expression [GO:0010468]; regulation of neuron projection development [GO:0010975]; regulation of phosphorylation [GO:0042325]; regulation of postsynapse organization [GO:0099175]; regulation of resting membrane potential [GO:0060075]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle cycle [GO:0098693]; response to oxidative stress [GO:0006979]; sequestering of calcium ion [GO:0051208]; skeletal system morphogenesis [GO:0048705]; skin morphogenesis [GO:0043589]; smooth endoplasmic reticulum calcium ion homeostasis [GO:0051563]; somitogenesis [GO:0001756]; synapse organization [GO:0050808]; synaptic vesicle targeting [GO:0016080]; T cell activation involved in immune response [GO:0002286]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]	aggresome [GO:0016235]; apical plasma membrane [GO:0016324]; azurophil granule membrane [GO:0035577]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell surface [GO:0009986]; centrosome [GO:0005813]; ciliary rootlet [GO:0035253]; dendritic shaft [GO:0043198]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gamma-secretase complex [GO:0070765]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; kinetochore [GO:0000776]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; rough endoplasmic reticulum [GO:0005791]; sarcolemma [GO:0042383]; smooth endoplasmic reticulum [GO:0005790]; synaptic vesicle [GO:0008021]; Z disc [GO:0030018]	aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; aspartic-type endopeptidase activity [GO:0004190]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium channel activity [GO:0005262]; endopeptidase activity [GO:0004175]; growth factor receptor binding [GO:0070851]; PDZ domain binding [GO:0030165]	aggresome [GO:0016235]; apical plasma membrane [GO:0016324]; azurophil granule membrane [GO:0035577]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell surface [GO:0009986]; centrosome [GO:0005813]; ciliary rootlet [GO:0035253]; dendritic shaft [GO:0043198]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gamma-secretase complex [GO:0070765]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; kinetochore [GO:0000776]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; rough endoplasmic reticulum [GO:0005791]; sarcolemma [GO:0042383]; smooth endoplasmic reticulum [GO:0005790]; synaptic vesicle [GO:0008021]; Z disc [GO:0030018]; aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; aspartic-type endopeptidase activity [GO:0004190]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium channel activity [GO:0005262]; endopeptidase activity [GO:0004175]; growth factor receptor binding [GO:0070851]; PDZ domain binding [GO:0030165]; amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; amyloid-beta metabolic process [GO:0050435]; apoptotic signaling pathway [GO:0097190]; astrocyte activation [GO:0048143]; astrocyte activation involved in immune response [GO:0002265]; autophagosome assembly [GO:0000045]; blood vessel development [GO:0001568]; brain morphogenesis [GO:0048854]; Cajal-Retzius cell differentiation [GO:0021870]; calcium ion transport [GO:0006816]; cell fate specification [GO:0001708]; cell-cell adhesion [GO:0098609]; cellular response to amyloid-beta [GO:1904646]; cerebellum development [GO:0021549]; cerebral cortex cell migration [GO:0021795]; choline transport [GO:0015871]; DNA damage response [GO:0006974]; dorsal/ventral neural tube patterning [GO:0021904]; embryonic limb morphogenesis [GO:0030326]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial cell proliferation [GO:0050673]; heart looping [GO:0001947]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular signal transduction [GO:0035556]; L-glutamate import across plasma membrane [GO:0098712]; learning or memory [GO:0007611]; locomotion [GO:0040011]; membrane protein ectodomain proteolysis [GO:0006509]; memory [GO:0007613]; mitochondrial transport [GO:0006839]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of axonogenesis [GO:0050771]; negative regulation of core promoter binding [GO:1904797]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural retina development [GO:0003407]; neuron apoptotic process [GO:0051402]; neuron cellular homeostasis [GO:0070050]; neuron development [GO:0048666]; neuron migration [GO:0001764]; neuron projection maintenance [GO:1990535]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of apoptotic process [GO:0043065]; positive regulation of catalytic activity [GO:0043085]; positive regulation of coagulation [GO:0050820]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of L-glutamate import across plasma membrane [GO:0002038]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor recycling [GO:0001921]; positive regulation of tumor necrosis factor production [GO:0032760]; post-embryonic development [GO:0009791]; protein catabolic process at postsynapse [GO:0140249]; protein processing [GO:0016485]; protein transport [GO:0015031]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of gene expression [GO:0010468]; regulation of neuron projection development [GO:0010975]; regulation of phosphorylation [GO:0042325]; regulation of postsynapse organization [GO:0099175]; regulation of resting membrane potential [GO:0060075]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle cycle [GO:0098693]; response to oxidative stress [GO:0006979]; sequestering of calcium ion [GO:0051208]; skeletal system morphogenesis [GO:0048705]; skin morphogenesis [GO:0043589]; smooth endoplasmic reticulum calcium ion homeostasis [GO:0051563]; somitogenesis [GO:0001756]; synapse organization [GO:0050808]; synaptic vesicle targeting [GO:0016080]; T cell activation involved in immune response [GO:0002286]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:25394380}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:8574969, ECO:0000269|PubMed:9738936, ECO:0000305|PubMed:10037471, ECO:0000305|PubMed:15274632}; Multi-pass membrane protein {ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Golgi apparatus membrane {ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:8574969, ECO:0000305|PubMed:10037471, ECO:0000305|PubMed:15274632}; Multi-pass membrane protein {ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Cytoplasmic granule {ECO:0000269|PubMed:11987239}. Cell membrane {ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:11987239, ECO:0000269|PubMed:21143716}; Multi-pass membrane protein {ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Cell projection, growth cone {ECO:0000269|PubMed:15004326}. Early endosome {ECO:0000269|PubMed:25394380}. Early endosome membrane {ECO:0000305|PubMed:25394380}; Multi-pass membrane protein {ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Cell projection, neuron projection {ECO:0000269|PubMed:15004326}. Cell projection, axon {ECO:0000250|UniProtKB:Q4JIM4}. Synapse {ECO:0000250|UniProtKB:Q4JIM4}. Note=Translocates with bound NOTCH1 from the endoplasmic reticulum and/or Golgi to the cell surface (PubMed:10593990). Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane (PubMed:9738936). Also present in azurophil granules of neutrophils (PubMed:11987239). Colocalizes with UBQLN1 in the cell membrane and in cytoplasmic juxtanuclear structures called aggresomes (PubMed:21143716). {ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:11987239, ECO:0000269|PubMed:21143716, ECO:0000269|PubMed:9738936}.
P49770	reviewed	EI2BB_HUMAN	Translation initiation factor eIF-2B subunit beta (S20I15) (S20III15) (eIF-2B GDP-GTP exchange factor subunit beta)	EIF2B2 EIF2BB	Homo sapiens (Human)	351	FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.		central nervous system development [GO:0007417]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; regulation of translational initiation [GO:0006446]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; translation initiation factor activity [GO:0003743]; central nervous system development [GO:0007417]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; regulation of translational initiation [GO:0006446]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	
P49771	reviewed	FLT3L_HUMAN	Fms-related tyrosine kinase 3 ligand (Flt3 ligand) (Flt3L) (SL cytokine)	FLT3LG	Homo sapiens (Human)	235	FUNCTION: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.		embryonic hemopoiesis [GO:0035162]; positive regulation of cell population proliferation [GO:0008284]; signal transduction [GO:0007165]	cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; embryonic hemopoiesis [GO:0035162]; positive regulation of cell population proliferation [GO:0008284]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
P49773	reviewed	HINT1_HUMAN	Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)	HINT1 HINT PKCI1 PRKCNH1	Homo sapiens (Human)	126	FUNCTION: Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:15703176, PubMed:16835243, PubMed:17337452, PubMed:17217311, PubMed:23614568, PubMed:28691797, PubMed:29787766, PubMed:31990367, PubMed:22329685). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (PubMed:15703176, PubMed:16835243). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (PubMed:15703176, PubMed:22329685, PubMed:17337452). Hydrolyzes 3-indolepropionic acyl-adenylate, tryptamine adenosine phosphoramidate monoester and other fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17337452, PubMed:23614568, PubMed:29787766, PubMed:17217311, PubMed:28691797, PubMed:31990367). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (PubMed:30772266). In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (PubMed:16014379, PubMed:22647378). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis (PubMed:16835243). Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:19112177). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RGS17 (PubMed:31088288). Deconjugates SUMO1 from RANGAP1 (By similarity). {ECO:0000250|UniProtKB:P80912, ECO:0000269|PubMed:15703176, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16835243, ECO:0000269|PubMed:17217311, ECO:0000269|PubMed:17337452, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:22329685, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:23614568, ECO:0000269|PubMed:28691797, ECO:0000269|PubMed:29787766, ECO:0000269|PubMed:30772266, ECO:0000269|PubMed:31088288, ECO:0000269|PubMed:31990367}.		intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of calcium-mediated signaling [GO:0050850]; protein desumoylation [GO:0016926]; purine ribonucleotide catabolic process [GO:0009154]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	adenosine 5'-monophosphoramidase activity [GO:0043530]; deSUMOylase activity [GO:0016929]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166]; protein kinase C binding [GO:0005080]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; adenosine 5'-monophosphoramidase activity [GO:0043530]; deSUMOylase activity [GO:0016929]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166]; protein kinase C binding [GO:0005080]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of calcium-mediated signaling [GO:0050850]; protein desumoylation [GO:0016926]; purine ribonucleotide catabolic process [GO:0009154]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10958787, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:8812426}. Nucleus {ECO:0000269|PubMed:10958787, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:9770345}. Note=Interaction with CDK7 leads to a more nuclear localization. {ECO:0000269|PubMed:10958787}.
P49788	reviewed	TIG1_HUMAN	Retinoic acid receptor responder protein 1 (Phorbol ester-induced gene 1 protein) (PERG-1) (RAR-responsive protein TIG1) (Tazarotene-induced gene 1 protein)	RARRES1 PEIG1 TIG1	Homo sapiens (Human)	294	FUNCTION: Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle. {ECO:0000269|PubMed:21303978}.		negative regulation of cell population proliferation [GO:0008285]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]	metalloendopeptidase inhibitor activity [GO:0008191]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; metalloendopeptidase inhibitor activity [GO:0008191]; negative regulation of cell population proliferation [GO:0008285]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:21303978}; Single-pass type III membrane protein {ECO:0000269|PubMed:21303978}. Secreted {ECO:0000269|PubMed:36213313}.
P49789	reviewed	FHIT_HUMAN	Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Adenosine 5'-monophosphoramidase FHIT) (EC 3.9.1.-) (Adenylylsulfatase) (EC 3.6.2.1) (Adenylylsulfate-ammonia adenylyltransferase) (EC 2.7.7.51) (Diadenosine 5',5'''-P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (Fragile histidine triad protein)	FHIT	Homo sapiens (Human)	147	FUNCTION: Possesses dinucleoside triphosphate hydrolase activity (PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9576908, PubMed:9543008). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9576908, PubMed:9543008). Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (PubMed:8794732). Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (PubMed:18694747). Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:18694747). Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (PubMed:26181368). Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (PubMed:26181368). Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (PubMed:18077326). Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (PubMed:16407838). Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (PubMed:15313915). Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake (PubMed:12574506, PubMed:19622739). Functions as tumor suppressor (By similarity). {ECO:0000250|UniProtKB:O89106, ECO:0000269|PubMed:12574506, ECO:0000269|PubMed:15313915, ECO:0000269|PubMed:16407838, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18694747, ECO:0000269|PubMed:19622739, ECO:0000269|PubMed:26181368, ECO:0000269|PubMed:8794732, ECO:0000269|PubMed:9323207, ECO:0000269|PubMed:9543008}.		diadenosine triphosphate catabolic process [GO:0015964]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; purine nucleotide metabolic process [GO:0006163]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	adenosine 5'-monophosphoramidase activity [GO:0043530]; adenylylsulfatase activity [GO:0047627]; adenylylsulfate-ammonia adenylyltransferase activity [GO:0047352]; bis(5'-adenosyl)-triphosphatase activity [GO:0047710]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; adenosine 5'-monophosphoramidase activity [GO:0043530]; adenylylsulfatase activity [GO:0047627]; adenylylsulfate-ammonia adenylyltransferase activity [GO:0047352]; bis(5'-adenosyl)-triphosphatase activity [GO:0047710]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; ubiquitin protein ligase binding [GO:0031625]; diadenosine triphosphate catabolic process [GO:0015964]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; purine nucleotide metabolic process [GO:0006163]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15007172, ECO:0000269|PubMed:15313915}. Mitochondrion {ECO:0000269|PubMed:19622739}. Nucleus {ECO:0000269|PubMed:15313915}.
P49790	reviewed	NU153_HUMAN	Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)	NUP153	Homo sapiens (Human)	1475	FUNCTION: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}.		mRNA transport [GO:0051028]; negative regulation of RNA export from nucleus [GO:0046832]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732]	cytosol [GO:0005829]; host cell [GO:0043657]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nuclear localization sequence binding [GO:0008139]; protein-membrane adaptor activity [GO:0043495]; structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; host cell [GO:0043657]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nuclear localization sequence binding [GO:0008139]; protein-membrane adaptor activity [GO:0043495]; structural constituent of nuclear pore [GO:0017056]; mRNA transport [GO:0051028]; negative regulation of RNA export from nucleus [GO:0046832]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732]	SUBCELLULAR LOCATION: Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Tightly associated with the nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Dissociates from the NPC structure early during prophase of mitosis. Integrated in the newly assembled nuclear envelope of postmitotic cells early in G1. Colocalized with NUP98 and TPR to the nuclear basket at the nucleoplasmic side of the NPC. Detected in diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV) infection. {ECO:0000250}.
P49792	reviewed	RBP2_HUMAN	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	RANBP2 NUP358	Homo sapiens (Human)	3224	FUNCTION: E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:22194619, PubMed:15931224). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.		centrosome localization [GO:0051642]; mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear export [GO:0051168]; nucleocytoplasmic transport [GO:0006913]; protein folding [GO:0006457]; protein sumoylation [GO:0016925]; regulation of gluconeogenesis [GO:0006111]; response to amphetamine [GO:0001975]	annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; SUMO ligase complex [GO:0106068]	metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]	annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; SUMO ligase complex [GO:0106068]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; centrosome localization [GO:0051642]; mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear export [GO:0051168]; nucleocytoplasmic transport [GO:0006913]; protein folding [GO:0006457]; protein sumoylation [GO:0016925]; regulation of gluconeogenesis [GO:0006111]; response to amphetamine [GO:0001975]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7775481}. Nucleus membrane {ECO:0000269|PubMed:11839768}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7603572}. Nucleus envelope {ECO:0000269|PubMed:20386726}. Note=Detected in diffuse and discrete intranuclear foci (PubMed:11839768). Cytoplasmic filaments (PubMed:7775481). {ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:7775481}.
P49795	reviewed	RGS19_HUMAN	Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP)	RGS19 GAIP GNAI3IP	Homo sapiens (Human)	217	FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.		autophagy [GO:0006914]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; response to ethanol [GO:0045471]; small GTPase mediated signal transduction [GO:0007264]	brush border [GO:0005903]; clathrin-coated vesicle [GO:0030136]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]	G-protein alpha-subunit binding [GO:0001965]; GTPase activity [GO:0003924]	brush border [GO:0005903]; clathrin-coated vesicle [GO:0030136]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; G-protein alpha-subunit binding [GO:0001965]; GTPase activity [GO:0003924]; autophagy [GO:0006914]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; response to ethanol [GO:0045471]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
P49796	reviewed	RGS3_HUMAN	Regulator of G-protein signaling 3 (RGP3) (RGS3)	RGS3	Homo sapiens (Human)	1198	FUNCTION: Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}.	MISCELLANEOUS: [Isoform 2]: Nuclear. {ECO:0000269|PubMed:10749886}.	G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9858594}. Nucleus {ECO:0000269|PubMed:10749886}. Cell membrane {ECO:0000269|PubMed:9858594}; Peripheral membrane protein {ECO:0000269|PubMed:9858594}. Note=Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886).
P49798	reviewed	RGS4_HUMAN	Regulator of G-protein signaling 4 (RGP4) (RGS4)	RGS4	Homo sapiens (Human)	205	FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.		dorsal root ganglion development [GO:1990791]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of dopamine receptor signaling pathway [GO:0060160]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of glycine import across plasma membrane [GO:1900924]; negative regulation of potassium ion transmembrane transport [GO:1901380]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of heart rate [GO:0010460]; regulation of actin filament organization [GO:0110053]; regulation of calcium ion transport [GO:0051924]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to amphetamine [GO:0001975]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	calmodulin binding [GO:0005516]; G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; calmodulin binding [GO:0005516]; G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; dorsal root ganglion development [GO:1990791]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of dopamine receptor signaling pathway [GO:0060160]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of glycine import across plasma membrane [GO:1900924]; negative regulation of potassium ion transmembrane transport [GO:1901380]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of heart rate [GO:0010460]; regulation of actin filament organization [GO:0110053]; regulation of calcium ion transport [GO:0051924]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to amphetamine [GO:0001975]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]	
P49802	reviewed	RGS7_HUMAN	Regulator of G-protein signaling 7 (RGS7)	RGS7	Homo sapiens (Human)	495	FUNCTION: GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades (PubMed:10521509, PubMed:10862767, PubMed:31189666). The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). May play a role in synaptic vesicle exocytosis (PubMed:12659861) (Probable). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264). {ECO:0000250|UniProtKB:O54829, ECO:0000269|PubMed:10521509, ECO:0000269|PubMed:10862767, ECO:0000269|PubMed:15897264, ECO:0000269|PubMed:31189666, ECO:0000305|PubMed:12659861}.		G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of GTPase activity [GO:0043547]; positive regulation of potassium ion transmembrane transport [GO:1901381]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to amphetamine [GO:0001975]; response to ethanol [GO:0045471]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of GTPase activity [GO:0043547]; positive regulation of potassium ion transmembrane transport [GO:1901381]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to amphetamine [GO:0001975]; response to ethanol [GO:0045471]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10521509}. Cytoplasm {ECO:0000269|PubMed:10339594, ECO:0000269|PubMed:15897264}. Cell membrane {ECO:0000269|PubMed:10339594, ECO:0000269|PubMed:15897264}. Membrane {ECO:0000269|PubMed:10521509}; Peripheral membrane protein {ECO:0000269|PubMed:10521509}; Cytoplasmic side {ECO:0000305}. Note=Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594). Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264). {ECO:0000269|PubMed:10339594, ECO:0000269|PubMed:15897264}.
P49810	reviewed	PSN2_HUMAN	Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]	PSEN2 AD4 PS2 PSNL2 STM2	Homo sapiens (Human)	448	FUNCTION: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:21285369}.		amyloid precursor protein catabolic process [GO:0042987]; amyloid-beta formation [GO:0034205]; amyloid-beta metabolic process [GO:0050435]; calcium ion transport [GO:0006816]; intracellular signal transduction [GO:0035556]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; negative regulation of apoptotic process [GO:0043066]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of catalytic activity [GO:0043085]; protein processing [GO:0016485]; regulation of calcium import into the mitochondrion [GO:0110097]; response to hypoxia [GO:0001666]	apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; cell surface [GO:0009986]; centrosome [GO:0005813]; ciliary rootlet [GO:0035253]; dendritic shaft [GO:0043198]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; kinetochore [GO:0000776]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; nuclear inner membrane [GO:0005637]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synaptic vesicle [GO:0008021]; Z disc [GO:0030018]	aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; endopeptidase activity [GO:0004175]	apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; cell surface [GO:0009986]; centrosome [GO:0005813]; ciliary rootlet [GO:0035253]; dendritic shaft [GO:0043198]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; kinetochore [GO:0000776]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; nuclear inner membrane [GO:0005637]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synaptic vesicle [GO:0008021]; Z disc [GO:0030018]; aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; endopeptidase activity [GO:0004175]; amyloid precursor protein catabolic process [GO:0042987]; amyloid-beta formation [GO:0034205]; amyloid-beta metabolic process [GO:0050435]; calcium ion transport [GO:0006816]; intracellular signal transduction [GO:0035556]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; negative regulation of apoptotic process [GO:0043066]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of catalytic activity [GO:0043085]; protein processing [GO:0016485]; regulation of calcium import into the mitochondrion [GO:0110097]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8574969}; Multi-pass membrane protein {ECO:0000269|PubMed:8574969}. Golgi apparatus membrane {ECO:0000269|PubMed:8574969}; Multi-pass membrane protein {ECO:0000269|PubMed:8574969}.
P49815	reviewed	TSC2_HUMAN	Tuberin (Tuberous sclerosis 2 protein)	TSC2 TSC4	Homo sapiens (Human)	1807	FUNCTION: Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:12842888, PubMed:28215400, PubMed:35772404, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12906785, PubMed:12842888, PubMed:15340059, PubMed:12820960, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:12842888, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}.	MISCELLANEOUS: [Isoform 8]: May be due to an intron retention. {ECO:0000305}.	anoikis [GO:0043276]; cellular response to starvation [GO:0009267]; endocytosis [GO:0006897]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of mitophagy [GO:1901525]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of Wnt signaling pathway [GO:0030178]; neural tube closure [GO:0001843]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive chemotaxis [GO:0050918]; positive regulation of macroautophagy [GO:0016239]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; regulation of cell cycle [GO:0051726]; regulation of endocytosis [GO:0030100]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of small GTPase mediated signal transduction [GO:0051056]; vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; TSC1-TSC2 complex [GO:0033596]	GTPase activator activity [GO:0005096]; Hsp90 protein binding [GO:0051879]; phosphatase binding [GO:0019902]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; TSC1-TSC2 complex [GO:0033596]; GTPase activator activity [GO:0005096]; Hsp90 protein binding [GO:0051879]; phosphatase binding [GO:0019902]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; anoikis [GO:0043276]; cellular response to starvation [GO:0009267]; endocytosis [GO:0006897]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of mitophagy [GO:1901525]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of Wnt signaling pathway [GO:0030178]; neural tube closure [GO:0001843]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive chemotaxis [GO:0050918]; positive regulation of macroautophagy [GO:0016239]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; regulation of cell cycle [GO:0051726]; regulation of endocytosis [GO:0030100]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of small GTPase mediated signal transduction [GO:0051056]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:24529379}; Peripheral membrane protein {ECO:0000269|PubMed:24529379}. Cytoplasm, cytosol {ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:24529379}. Note=Recruited to lysosomal membranes in a RHEB-dependent process in absence of nutrients (PubMed:24529379). In response to insulin signaling and phosphorylation by PKB/AKT1, the complex dissociates from lysosomal membranes and relocalizes to the cytosol (PubMed:24529379). {ECO:0000269|PubMed:24529379}.
P49821	reviewed	NDUV1_HUMAN	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 7.1.1.2) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1) (NADH-ubiquinone oxidoreductase 51 kDa subunit)	NDUFV1 UQOR1	Homo sapiens (Human)	464	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. {ECO:0000250|UniProtKB:P25708}.		aerobic respiration [GO:0009060]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; 4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P25708}; Peripheral membrane protein {ECO:0000250|UniProtKB:P25708}; Matrix side {ECO:0000250|UniProtKB:P25708}.
P49840	reviewed	GSK3A_HUMAN	Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)	GSK3A	Homo sapiens (Human)	483	FUNCTION: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions which activates KAT5/TIP60 acetyltransferase activity and promotes acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). {ECO:0000250|UniProtKB:P18265, ECO:0000250|UniProtKB:P49841, ECO:0000250|UniProtKB:Q2NL51, ECO:0000269|PubMed:10868943, ECO:0000269|PubMed:12761548, ECO:0000269|PubMed:17229088, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:30704899, ECO:0000303|PubMed:11749387, ECO:0000303|PubMed:17478001, ECO:0000303|PubMed:19366350}.	MISCELLANEOUS: Higher expression and activity of GSK3A are found in the skeletal muscle (vastus lateralis) of patients with type 2 diabetes (PubMed:10868943). Several potent GSK3 (GSK3A and GSK3B) inhibitors have been identified and characterized in preclinical models for treatments of type 2 diabetes (PubMed:19366350). {ECO:0000305|PubMed:10868943, ECO:0000305|PubMed:19366350}.	cardiac left ventricle morphogenesis [GO:0003214]; cell migration [GO:0016477]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-3 [GO:0036016]; cellular response to lithium ion [GO:0071285]; dopamine receptor signaling pathway [GO:0007212]; excitatory postsynaptic potential [GO:0060079]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; glycogen metabolic process [GO:0005977]; insulin receptor signaling pathway [GO:0008286]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of gene expression via CpG island methylation [GO:0044027]; negative regulation of glucose import [GO:0046325]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of glycogen synthase activity, transferring glucose-1-phosphate [GO:1904227]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of TOR signaling [GO:0032007]; negative regulation of type B pancreatic cell development [GO:2000077]; negative regulation of UDP-glucose catabolic process [GO:0010905]; nervous system development [GO:0007399]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071879]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of autophagy [GO:0010508]; positive regulation of gene expression [GO:0010628]; positive regulation of glycogen (starch) synthase activity [GO:2000467]; positive regulation of heart contraction [GO:0045823]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein phosphorylation [GO:0006468]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of neuron projection development [GO:0010975]; regulation of systemic arterial blood pressure [GO:0003073]; viral protein processing [GO:0019082]; Wnt signaling pathway [GO:0016055]	apical dendrite [GO:0097440]; axon [GO:0030424]; beta-catenin destruction complex [GO:0030877]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynapse [GO:0098794]; proximal dendrite [GO:1990635]	ATP binding [GO:0005524]; protein kinase A catalytic subunit binding [GO:0034236]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor binding [GO:0005102]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	apical dendrite [GO:0097440]; axon [GO:0030424]; beta-catenin destruction complex [GO:0030877]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynapse [GO:0098794]; proximal dendrite [GO:1990635]; ATP binding [GO:0005524]; protein kinase A catalytic subunit binding [GO:0034236]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor binding [GO:0005102]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; cardiac left ventricle morphogenesis [GO:0003214]; cell migration [GO:0016477]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-3 [GO:0036016]; cellular response to lithium ion [GO:0071285]; dopamine receptor signaling pathway [GO:0007212]; excitatory postsynaptic potential [GO:0060079]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; glycogen metabolic process [GO:0005977]; insulin receptor signaling pathway [GO:0008286]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of gene expression via CpG island methylation [GO:0044027]; negative regulation of glucose import [GO:0046325]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of glycogen synthase activity, transferring glucose-1-phosphate [GO:1904227]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of TOR signaling [GO:0032007]; negative regulation of type B pancreatic cell development [GO:2000077]; negative regulation of UDP-glucose catabolic process [GO:0010905]; nervous system development [GO:0007399]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071879]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of autophagy [GO:0010508]; positive regulation of gene expression [GO:0010628]; positive regulation of glycogen (starch) synthase activity [GO:2000467]; positive regulation of heart contraction [GO:0045823]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein phosphorylation [GO:0006468]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of neuron projection development [GO:0010975]; regulation of systemic arterial blood pressure [GO:0003073]; viral protein processing [GO:0019082]; Wnt signaling pathway [GO:0016055]	
P49841	reviewed	GSK3B_HUMAN	Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)	GSK3B	Homo sapiens (Human)	420	FUNCTION: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 (PubMed:1846781, PubMed:9072970, PubMed:14690523, PubMed:20937854, PubMed:12554650, PubMed:11430833, PubMed:16484495). Requires primed phosphorylation of the majority of its substrates (PubMed:11430833, PubMed:16484495). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (PubMed:8397507). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (PubMed:12554650). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA (PubMed:1846781). Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin (PubMed:9072970). Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules (PubMed:14690523). MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease (PubMed:14690523). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (By similarity). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) (By similarity). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin (PubMed:9819408). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:20067585). Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity (PubMed:18348280). Phosphorylates ZC3HAV1 which enhances its antiviral activity (PubMed:22514281). Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation (PubMed:15448698, PubMed:15647282). Phosphorylates SFPQ at 'Thr-687' upon T-cell activation (PubMed:20932480). Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110). Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (PubMed:17050006, PubMed:28992046). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (By similarity). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P18266, ECO:0000250|UniProtKB:Q9WV60, ECO:0000269|PubMed:11430833, ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16484495, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:1846781, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19946213, ECO:0000269|PubMed:20067585, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:22514281, ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:28903391, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:8397507, ECO:0000269|PubMed:9072970, ECO:0000269|PubMed:9819408}.	MISCELLANEOUS: Higher expression and activity of GSK3B are found in the skeletal muscle (vastus lateralis) of patients with type 2 diabetes (PubMed:10868943). Several potent GSK3 (GSK3A and GSK3B) inhibitors have been identified and characterized in preclinical models for treatments of type 2 diabetes (PubMed:19366350). {ECO:0000305|PubMed:10868943, ECO:0000305|PubMed:19366350}.; MISCELLANEOUS: [Isoform 2]: May play a specific role in axon growth and neurite outgrowth. Reduced binding to AXIN1, reduced ability to phosphorylate MAPT/TAU. {ECO:0000269|PubMed:20067585}.	beta-catenin destruction complex disassembly [GO:1904886]; cellular response to amyloid-beta [GO:1904646]; cellular response to interleukin-3 [GO:0036016]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; dopamine receptor signaling pathway [GO:0007212]; epithelial to mesenchymal transition [GO:0001837]; ER overload response [GO:0006983]; establishment of cell polarity [GO:0030010]; excitatory postsynaptic potential [GO:0060079]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; glycogen metabolic process [GO:0005977]; heart valve development [GO:0003170]; hippocampus development [GO:0021766]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation [GO:1905240]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of gene expression [GO:0010629]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of mesenchymal stem cell differentiation [GO:2000740]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein binding [GO:0032091]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of type B pancreatic cell development [GO:2000077]; neuron projection development [GO:0031175]; neuron projection organization [GO:0106027]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagy [GO:0010508]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cilium assembly [GO:0045724]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of mitochondrion organization [GO:0010822]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of protein-containing complex assembly [GO:0031334]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon extension [GO:0030516]; regulation of axonogenesis [GO:0050770]; regulation of cellular response to heat [GO:1900034]; regulation of circadian rhythm [GO:0042752]; regulation of dendrite morphogenesis [GO:0048814]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of microtubule anchoring at centrosome [GO:0150101]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule-based process [GO:0032886]; regulation of neuron projection development [GO:0010975]; regulation of protein export from nucleus [GO:0046825]; superior temporal gyrus development [GO:0071109]; viral protein processing [GO:0019082]	axon [GO:0030424]; beta-catenin destruction complex [GO:0030877]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; Wnt signalosome [GO:1990909]	ATP binding [GO:0005524]; beta-catenin binding [GO:0008013]; dynactin binding [GO:0034452]; kinase activity [GO:0016301]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; protease binding [GO:0002020]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; ubiquitin protein ligase binding [GO:0031625]	axon [GO:0030424]; beta-catenin destruction complex [GO:0030877]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; Wnt signalosome [GO:1990909]; ATP binding [GO:0005524]; beta-catenin binding [GO:0008013]; dynactin binding [GO:0034452]; kinase activity [GO:0016301]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; protease binding [GO:0002020]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; ubiquitin protein ligase binding [GO:0031625]; beta-catenin destruction complex disassembly [GO:1904886]; cellular response to amyloid-beta [GO:1904646]; cellular response to interleukin-3 [GO:0036016]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; dopamine receptor signaling pathway [GO:0007212]; epithelial to mesenchymal transition [GO:0001837]; ER overload response [GO:0006983]; establishment of cell polarity [GO:0030010]; excitatory postsynaptic potential [GO:0060079]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; glycogen metabolic process [GO:0005977]; heart valve development [GO:0003170]; hippocampus development [GO:0021766]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation [GO:1905240]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of gene expression [GO:0010629]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of mesenchymal stem cell differentiation [GO:2000740]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein binding [GO:0032091]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of type B pancreatic cell development [GO:2000077]; neuron projection development [GO:0031175]; neuron projection organization [GO:0106027]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagy [GO:0010508]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cilium assembly [GO:0045724]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of mitochondrion organization [GO:0010822]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of protein-containing complex assembly [GO:0031334]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon extension [GO:0030516]; regulation of axonogenesis [GO:0050770]; regulation of cellular response to heat [GO:1900034]; regulation of circadian rhythm [GO:0042752]; regulation of dendrite morphogenesis [GO:0048814]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of microtubule anchoring at centrosome [GO:0150101]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule-based process [GO:0032886]; regulation of neuron projection development [GO:0010975]; regulation of protein export from nucleus [GO:0046825]; superior temporal gyrus development [GO:0071109]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21029237, ECO:0000269|PubMed:25169422}. Nucleus {ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:21029237}. Cell membrane {ECO:0000269|PubMed:20937854}. Note=The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). {ECO:0000269|PubMed:20937854}.
P49842	reviewed	STK19_HUMAN	Inactive serine/threonine-protein kinase 19 (Protein G11) (Protein RP1)	STK19 G11 RP1	Homo sapiens (Human)	254	FUNCTION: [Isoform 1]: Inactive serine/threonine-protein kinase (PubMed:32531246, PubMed:32531245) (Probable). May control NRAS activity via an associated kinase (PubMed:32531246) (Probable). {ECO:0000269|PubMed:32531245, ECO:0000305|PubMed:32531246}.; FUNCTION: [Isoform 3]: Inactive serine/threonine-protein kinase. {ECO:0000269|PubMed:32531245}.		positive regulation of Ras protein signal transduction [GO:0046579]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; positive regulation of Ras protein signal transduction [GO:0046579]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:32531245}. Note=Very tightly chromatin-associated. {ECO:0000269|PubMed:32531245}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:32531246, ECO:0000269|PubMed:9812991}. Cytoplasm {ECO:0000269|PubMed:32531246}.
P49848	reviewed	TAF6_HUMAN	Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80)	TAF6 TAF2E TAFII70	Homo sapiens (Human)	677	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}.		apoptotic process [GO:0006915]; DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	cytosol [GO:0005829]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]	aryl hydrocarbon receptor binding [GO:0017162]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; aryl hydrocarbon receptor binding [GO:0017162]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription coactivator activity [GO:0003713]; apoptotic process [GO:0006915]; DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000269|PubMed:18628956}.
P49862	reviewed	KLK7_HUMAN	Kallikrein-7 (hK7) (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (hSCCE)	KLK7 PRSS6 SCCE	Homo sapiens (Human)	253	FUNCTION: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. {ECO:0000269|PubMed:23370777}.		epidermis development [GO:0008544]; extracellular matrix disassembly [GO:0022617]; positive regulation of antibacterial peptide production [GO:0002803]; proteolysis [GO:0006508]	cornified envelope [GO:0001533]; epidermal lamellar body [GO:0097209]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]	metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	cornified envelope [GO:0001533]; epidermal lamellar body [GO:0097209]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; epidermis development [GO:0008544]; extracellular matrix disassembly [GO:0022617]; positive regulation of antibacterial peptide production [GO:0002803]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12738725}. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
P49863	reviewed	GRAK_HUMAN	Granzyme K (EC 3.4.21.-) (Fragmentin-3) (Granzyme-3) (NK-tryptase-2) (NK-Tryp-2)	GZMK TRYP2	Homo sapiens (Human)	264			proteolysis [GO:0006508]	extracellular region [GO:0005576]; secretory granule [GO:0030141]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular region [GO:0005576]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule.
P49888	reviewed	ST1E1_HUMAN	Sulfotransferase 1E1 (ST1E1) (EC 2.8.2.4) (EST-1) (Estrogen sulfotransferase) (Sulfotransferase, estrogen-preferring)	SULT1E1 STE	Homo sapiens (Human)	294	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7779757, PubMed:11884392, PubMed:11006110). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875). Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. {ECO:0000269|PubMed:11006110, ECO:0000269|PubMed:11884392, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:35165440, ECO:0000269|PubMed:7779757}.		3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; estrogen catabolic process [GO:0006711]; estrogen metabolic process [GO:0008210]; ethanol catabolic process [GO:0006068]; positive regulation of fat cell differentiation [GO:0045600]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]	aryl sulfotransferase activity [GO:0004062]; estrone sulfotransferase activity [GO:0004304]; flavonol 3-sulfotransferase activity [GO:0047894]; steroid binding [GO:0005496]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; aryl sulfotransferase activity [GO:0004062]; estrone sulfotransferase activity [GO:0004304]; flavonol 3-sulfotransferase activity [GO:0047894]; steroid binding [GO:0005496]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; estrogen catabolic process [GO:0006711]; estrogen metabolic process [GO:0008210]; ethanol catabolic process [GO:0006068]; positive regulation of fat cell differentiation [GO:0045600]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11006110}.
P49895	reviewed	IOD1_HUMAN	Type I iodothyronine deiodinase (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase)	DIO1 ITDI1 TXDI1	Homo sapiens (Human)	249	FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney. {ECO:0000269|PubMed:32718224}.	MISCELLANEOUS: [Isoform 3]: The UGA codon in position 83 may either function as a selenocysteine codon or a translation termination codon. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. The UGA codon in position 34 may either function as a selenocysteine codon or a translation termination codon. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. The UGA codon in position 59 may either function as a selenocysteine codon or a translation termination codon. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. The UGA codon in position 59 may either function as a selenocysteine codon or a translation termination codon. {ECO:0000305}.	amino acid metabolic process [GO:0006520]; hormone biosynthetic process [GO:0042446]; thyroid hormone generation [GO:0006590]; thyroid hormone metabolic process [GO:0042403]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	selenium binding [GO:0008430]; thyroxine 5'-deiodinase activity [GO:0004800]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; selenium binding [GO:0008430]; thyroxine 5'-deiodinase activity [GO:0004800]; amino acid metabolic process [GO:0006520]; hormone biosynthetic process [GO:0042446]; thyroid hormone generation [GO:0006590]; thyroid hormone metabolic process [GO:0042403]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
P49901	reviewed	MCSP_HUMAN	Sperm mitochondrial-associated cysteine-rich protein	SMCP MCS MCSP	Homo sapiens (Human)	116	FUNCTION: Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity). {ECO:0000250}.		flagellated sperm motility [GO:0030317]; penetration of zona pellucida [GO:0007341]	cytoplasm [GO:0005737]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]		cytoplasm [GO:0005737]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; flagellated sperm motility [GO:0030317]; penetration of zona pellucida [GO:0007341]	SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis. {ECO:0000250}.
P49902	reviewed	5NTC_HUMAN	Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase)	NT5C2 NT5B NT5CP PNT5	Homo sapiens (Human)	561	FUNCTION: Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:1659319, PubMed:9371705, PubMed:10092873, PubMed:12907246). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:1659319, PubMed:9371705, PubMed:10092873, PubMed:12907246). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:1659319, PubMed:9371705, PubMed:10092873, PubMed:12907246). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}.		adenosine metabolic process [GO:0046085]; allantoin metabolic process [GO:0000255]; dGMP metabolic process [GO:0046054]; GMP metabolic process [GO:0046037]; IMP catabolic process [GO:0006204]; IMP metabolic process [GO:0046040]; negative regulation of defense response to virus by host [GO:0050689]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	5'-nucleotidase activity [GO:0008253]; ATP binding [GO:0005524]; GMP 5'-nucleotidase activity [GO:0050484]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; metal ion binding [GO:0046872]; nucleoside phosphotransferase activity [GO:0050146]; ubiquitin protein ligase activity [GO:0061630]; XMP 5'-nucleosidase activity [GO:0106411]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; 5'-nucleotidase activity [GO:0008253]; ATP binding [GO:0005524]; GMP 5'-nucleotidase activity [GO:0050484]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; metal ion binding [GO:0046872]; nucleoside phosphotransferase activity [GO:0050146]; ubiquitin protein ligase activity [GO:0061630]; XMP 5'-nucleosidase activity [GO:0106411]; adenosine metabolic process [GO:0046085]; allantoin metabolic process [GO:0000255]; dGMP metabolic process [GO:0046054]; GMP metabolic process [GO:0046037]; IMP catabolic process [GO:0006204]; IMP metabolic process [GO:0046040]; negative regulation of defense response to virus by host [GO:0050689]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:9371705}.
P49903	reviewed	SPS1_HUMAN	Selenide, water dikinase 1 (EC 2.7.9.3) (Selenium donor protein 1) (Selenophosphate synthase 1)	SEPHS1 SELD SPS SPS1	Homo sapiens (Human)	392	FUNCTION: Synthesizes selenophosphate from selenide and ATP. {ECO:0000269|PubMed:7665581}.		phosphorylation [GO:0016310]; protein modification process [GO:0036211]; selenocysteine biosynthetic process [GO:0016260]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; selenide, water dikinase activity [GO:0004756]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; selenide, water dikinase activity [GO:0004756]; phosphorylation [GO:0016310]; protein modification process [GO:0036211]; selenocysteine biosynthetic process [GO:0016260]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:20471958}; Peripheral membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000269|PubMed:20471958}; Peripheral membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:20471958}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:20471958}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:20471958}.
P49908	reviewed	SEPP1_HUMAN	Selenoprotein P (SeP)	SELENOP SELP SEPP1	Homo sapiens (Human)	381	FUNCTION: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.		brain development [GO:0007420]; locomotory behavior [GO:0007626]; post-embryonic development [GO:0009791]; regulation of growth [GO:0040008]; response to oxidative stress [GO:0006979]; selenium compound metabolic process [GO:0001887]; sexual reproduction [GO:0019953]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089]	selenium binding [GO:0008430]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089]; selenium binding [GO:0008430]; brain development [GO:0007420]; locomotory behavior [GO:0007626]; post-embryonic development [GO:0009791]; regulation of growth [GO:0040008]; response to oxidative stress [GO:0006979]; selenium compound metabolic process [GO:0001887]; sexual reproduction [GO:0019953]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8142465}. Note=Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium. {ECO:0000250|UniProtKB:P70274}.
P49910	reviewed	ZN165_HUMAN	Zinc finger protein 165 (Cancer/testis antigen 53) (CT53) (LD65) (Zinc finger and SCAN domain-containing protein 7)	ZNF165 ZPF165 ZSCAN7	Homo sapiens (Human)	485	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
P49913	reviewed	CAMP_HUMAN	Cathelicidin antimicrobial peptide (18 kDa cationic antimicrobial protein) (CAP-18) (hCAP-18) [Cleaved into: Antibacterial peptide FALL-39 (FALL-39 peptide antibiotic); Antibacterial peptide LL-37; Antibacterial peptide KR-20; Antibacterial peptide LL-23; Antibacterial peptide LL-29; Antibacterial peptide KS-30; Antibacterial peptide RK-31; Antibacterial peptide FF-33]	CAMP CAP18 FALL39 HSD26	Homo sapiens (Human)	170	FUNCTION: Antimicrobial protein that is an integral component of the innate immune system (PubMed:22879591, PubMed:16637646, PubMed:18818205, PubMed:9736536, PubMed:14978112). Binds to bacterial lipopolysaccharides (LPS) (PubMed:16637646, PubMed:18818205). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin (PubMed:14978112). The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro) (PubMed:9736536). {ECO:0000269|PubMed:14978112, ECO:0000269|PubMed:16637646, ECO:0000269|PubMed:18818205, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:9736536}.; FUNCTION: [Antibacterial peptide LL-37]: Antimicrobial peptide that is an integral component of the innate immune system (PubMed:8681941, PubMed:9736536, PubMed:10417311, PubMed:15778390, PubMed:22879591, PubMed:34708076, PubMed:16637646, PubMed:18818205, PubMed:32753597, PubMed:33060695). Binds to bacterial lipopolysaccharides (LPS) (PubMed:16637646, PubMed:18818205, PubMed:9736536, PubMed:10417311, PubMed:33060695). Causes membrane permeabilization by forming transmembrane pores (in vitro) (PubMed:22879591, PubMed:32753597, PubMed:33060695). Causes lysis of E.coli (PubMed:10417311). Exhibits antimicrobial activity against Gram-negative bacteria such as P.aeruginosa, S.typhimurium, E.aerogenes, E.coli and P.syringae, Gram-positive bacteria such as L.monocytogenes, S.epidermidis, S.pyogenes and S.aureus, as well as vancomycin-resistant enterococci (in vitro) (PubMed:8681941, PubMed:9736536, PubMed:10417311, PubMed:32753597). Exhibits antimicrobial activity against methicillin-resistant S.aureus, P.mirabilis, and C.albicans in low-salt media, but not in media containing 100 mM NaCl (in vitro) (PubMed:9736536). Forms chiral supramolecular assemblies with quinolone signal (PQS) molecules of P.aeruginosa, which may lead to interference of bacterial quorum signaling and perturbance of bacterial biofilm formation (PubMed:34708076). May form supramolecular fiber-like assemblies on bacterial membranes (PubMed:29133814). Induces cytokine and chemokine production as well as TNF/TNFA and CSF2/GMCSF production in normal human keratinocytes (PubMed:15778390). Exhibits hemolytic activity against red blood cells (PubMed:10417311). {ECO:0000269|PubMed:10417311, ECO:0000269|PubMed:15778390, ECO:0000269|PubMed:16637646, ECO:0000269|PubMed:18818205, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:29133814, ECO:0000269|PubMed:32753597, ECO:0000269|PubMed:33060695, ECO:0000269|PubMed:34708076, ECO:0000269|PubMed:8681941, ECO:0000269|PubMed:9736536}.; FUNCTION: [Antibacterial peptide FALL-39]: Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro). {ECO:0000269|PubMed:7529412, ECO:0000269|PubMed:8681941}.; FUNCTION: [Antibacterial peptide KR-20]: Acts synergistically with peptides KS-30 and KR-31, killing bacteria such as S.aureus, E.coli and C.albicans at lower concentrations when present together, and maintains activity at increased salt condition (PubMed:14978112). Does not have the ability to stimulate CXCL8/IL8 release from keratinocytes (PubMed:14978112). {ECO:0000269|PubMed:14978112}.; FUNCTION: [Antibacterial peptide LL-23]: Poorly active (MIC > 150 uM) against E.coli strain K12 (PubMed:14978112). Is able to induce the pro-inflammatory cytokine TNF/TNFA or the chemokine CCL2/MCP1 (PubMed:14978112). {ECO:0000269|PubMed:14978112}.; FUNCTION: [Antibacterial peptide LL-29]: Moderately antibacterial. {ECO:0000269|PubMed:14978112}.; FUNCTION: [Antibacterial peptide KS-30]: Moderately antibacterial (PubMed:14978112). Acts synergistically with peptides KR-20 and KR-31, killing bacteria such as S.aureus, E.coli and C.albicans at lower concentrations when present together, and maintain activity at increased salt condition (PubMed:14978112). Does not have the ability to stimulate CXCL8/IL8 release from keratinocytes (PubMed:14978112). {ECO:0000269|PubMed:14978112}.; FUNCTION: [Antibacterial peptide RK-31]: Acts synergistically with peptides KS-30 and KR-31, killing bacteria such as S.aureus, E.coli and C.albicans at lower concentrations when present together, and maintain activity at increased salt condition (PubMed:14978112). Does not have the ability to stimulate CXCL8/IL8 release from keratinocytes (PubMed:14978112). {ECO:0000269|PubMed:14978112}.; FUNCTION: [Antibacterial peptide FF-33]: Inhibits the growth of E.coli and B.megaterium and exhibits hemolytic activity against human red blood cells. {ECO:0000269|PubMed:14978112}.	MISCELLANEOUS: The propeptide shows high sequence homology to cathelin, a protein of 96 residues isolated from porcine neutrophils, and is therefore also named cathelin-like domain (CLD) (PubMed:9736536). Cathelin was initially classified into the cystatin family of cysteine protease inhibitors based on its inhibitory activity against cathepsin L (PubMed:9736536). Human CLD itself lacks antimicrobial function and does not inhibit the cysteine protease, cathepsin L (PubMed:9736536). {ECO:0000269|PubMed:9736536}.	amyloid fibril formation [GO:1990000]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to peptidoglycan [GO:0071224]; cellular response to tumor necrosis factor [GO:0071356]; cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; killing by host of symbiont cells [GO:0051873]; neutrophil activation [GO:0042119]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein phosphorylation [GO:0001934]	cell projection [GO:0042995]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	lipopolysaccharide binding [GO:0001530]	cell projection [GO:0042995]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; lipopolysaccharide binding [GO:0001530]; amyloid fibril formation [GO:1990000]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to peptidoglycan [GO:0071224]; cellular response to tumor necrosis factor [GO:0071356]; cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; killing by host of symbiont cells [GO:0051873]; neutrophil activation [GO:0042119]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein phosphorylation [GO:0001934]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14978112}. Vesicle {ECO:0000269|PubMed:7529412, ECO:0000269|PubMed:9736536}. Note=Stored as pro-peptide in granules and phagolysosomes of neutrophils (PubMed:9736536, PubMed:7529412). Secreted in sweat onto skin (PubMed:14978112). {ECO:0000269|PubMed:14978112, ECO:0000269|PubMed:7529412, ECO:0000269|PubMed:9736536}.
P49914	reviewed	MTHFS_HUMAN	5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)	MTHFS	Homo sapiens (Human)	203	FUNCTION: Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. {ECO:0000269|PubMed:8522195}.		folic acid catabolic process [GO:0046657]; folic acid metabolic process [GO:0046655]; folic acid-containing compound biosynthetic process [GO:0009396]; formate metabolic process [GO:0015942]; glutamate metabolic process [GO:0006536]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	5-formyltetrahydrofolate cyclo-ligase activity [GO:0030272]; ATP binding [GO:0005524]; folic acid binding [GO:0005542]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 5-formyltetrahydrofolate cyclo-ligase activity [GO:0030272]; ATP binding [GO:0005524]; folic acid binding [GO:0005542]; metal ion binding [GO:0046872]; folic acid catabolic process [GO:0046657]; folic acid metabolic process [GO:0046655]; folic acid-containing compound biosynthetic process [GO:0009396]; formate metabolic process [GO:0015942]; glutamate metabolic process [GO:0006536]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	SUBCELLULAR LOCATION: Cytoplasm.
P49915	reviewed	GUAA_HUMAN	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase)	GMPS	Homo sapiens (Human)	693	FUNCTION: Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate. {ECO:0000269|PubMed:8089153}.		glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]	cytosol [GO:0005829]	ATP binding [GO:0005524]; GMP synthase (glutamine-hydrolyzing) activity [GO:0003922]; GMP synthase activity [GO:0003921]	cytosol [GO:0005829]; ATP binding [GO:0005524]; GMP synthase (glutamine-hydrolyzing) activity [GO:0003922]; GMP synthase activity [GO:0003921]; glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:8089153}.
P49916	reviewed	DNLI3_HUMAN	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)	LIG3	Homo sapiens (Human)	1009	FUNCTION: Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative splicing.; MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative initiation of isoform 2. {ECO:0000305}.	base-excision repair, DNA ligation [GO:0006288]; base-excision repair, gap-filling [GO:0006287]; cell cycle [GO:0007049]; cell division [GO:0051301]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; lagging strand elongation [GO:0006273]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial DNA replication [GO:0090298]	DNA ligase III-XRCC1 complex [GO:0070421]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; zinc ion binding [GO:0008270]	DNA ligase III-XRCC1 complex [GO:0070421]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; zinc ion binding [GO:0008270]; base-excision repair, DNA ligation [GO:0006288]; base-excision repair, gap-filling [GO:0006287]; cell cycle [GO:0007049]; cell division [GO:0051301]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; lagging strand elongation [GO:0006273]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial DNA replication [GO:0090298]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. Note=Contains an N-terminal mitochondrial transit peptide. {ECO:0000269|PubMed:10207110}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000305|PubMed:10207110}. Note=Contains an N-terminal mitochondrial transit peptide. {ECO:0000305|PubMed:10207110}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:10207110}. Note=Lacks the N-terminal mitochondrial transit peptide. {ECO:0000269|PubMed:10207110}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000305|PubMed:10207110}. Note=Lacks the N-terminal mitochondrial transit peptide. {ECO:0000305|PubMed:10207110}.
P49917	reviewed	DNLI4_HUMAN	DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4)	LIG4	Homo sapiens (Human)	911	FUNCTION: DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination (PubMed:8798671, PubMed:9242410, PubMed:9809069, PubMed:12517771, PubMed:17290226). Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed (PubMed:9242410, PubMed:9809069, PubMed:12517771, PubMed:17290226). Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction (PubMed:9242410, PubMed:9809069, PubMed:12517771, PubMed:17290226). LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps (PubMed:17290226). Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4 (PubMed:9242410, PubMed:9809069). Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10854421). LIG4 regulates nuclear localization of XRCC4 (PubMed:24984242). {ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:24984242, ECO:0000269|PubMed:8798671, ECO:0000269|PubMed:9242410, ECO:0000269|PubMed:9809069}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; cellular response to ionizing radiation [GO:0071479]; cellular response to lithium ion [GO:0071285]; central nervous system development [GO:0007417]; chromosome organization [GO:0051276]; DN2 thymocyte differentiation [GO:1904155]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; DNA ligation involved in DNA recombination [GO:0051102]; DNA ligation involved in DNA repair [GO:0051103]; DNA replication [GO:0006260]; double-strand break repair [GO:0006302]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of integrated proviral latency [GO:0075713]; fibroblast proliferation [GO:0048144]; immunoglobulin V(D)J recombination [GO:0033152]; in utero embryonic development [GO:0001701]; isotype switching [GO:0045190]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; neuron apoptotic process [GO:0051402]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of chromosome organization [GO:2001252]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neurogenesis [GO:0050769]; pro-B cell differentiation [GO:0002328]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; somatic stem cell population maintenance [GO:0035019]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; T cell receptor V(D)J recombination [GO:0033153]; V(D)J recombination [GO:0033151]	chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; intracellular membrane-bounded organelle [GO:0043231]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]	chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; intracellular membrane-bounded organelle [GO:0043231]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; cellular response to ionizing radiation [GO:0071479]; cellular response to lithium ion [GO:0071285]; central nervous system development [GO:0007417]; chromosome organization [GO:0051276]; DN2 thymocyte differentiation [GO:1904155]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; DNA ligation involved in DNA recombination [GO:0051102]; DNA ligation involved in DNA repair [GO:0051103]; DNA replication [GO:0006260]; double-strand break repair [GO:0006302]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of integrated proviral latency [GO:0075713]; fibroblast proliferation [GO:0048144]; immunoglobulin V(D)J recombination [GO:0033152]; in utero embryonic development [GO:0001701]; isotype switching [GO:0045190]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; neuron apoptotic process [GO:0051402]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of chromosome organization [GO:2001252]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neurogenesis [GO:0050769]; pro-B cell differentiation [GO:0002328]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; somatic stem cell population maintenance [GO:0035019]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; T cell receptor V(D)J recombination [GO:0033153]; V(D)J recombination [GO:0033151]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:24984242, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:8798671}.
P49918	reviewed	CDN1C_HUMAN	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)	CDKN1C KIP2	Homo sapiens (Human)	316	FUNCTION: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.	MISCELLANEOUS: Paternally imprinted, therefore most expression comes from the maternal allele. {ECO:0000305|PubMed:26077438}.	adrenal gland development [GO:0030325]; camera-type eye development [GO:0043010]; cell cycle [GO:0007049]; digestive system development [GO:0055123]; embryonic placenta morphogenesis [GO:0060669]; genomic imprinting [GO:0071514]; kidney development [GO:0001822]; multicellular organism growth [GO:0035264]; myeloid cell differentiation [GO:0030099]; negative regulation of cyclin-dependent protein kinase activity [GO:1904030]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of kinase activity [GO:0033673]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphorylation [GO:0042326]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron maturation [GO:0042551]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of exit from mitosis [GO:0007096]; regulation of lens fiber cell differentiation [GO:1902746]; skeletal system development [GO:0001501]; uterus development [GO:0060065]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; molecular function inhibitor activity [GO:0140678]; protein kinase inhibitor activity [GO:0004860]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; molecular function inhibitor activity [GO:0140678]; protein kinase inhibitor activity [GO:0004860]; protein-containing complex binding [GO:0044877]; adrenal gland development [GO:0030325]; camera-type eye development [GO:0043010]; cell cycle [GO:0007049]; digestive system development [GO:0055123]; embryonic placenta morphogenesis [GO:0060669]; genomic imprinting [GO:0071514]; kidney development [GO:0001822]; multicellular organism growth [GO:0035264]; myeloid cell differentiation [GO:0030099]; negative regulation of cyclin-dependent protein kinase activity [GO:1904030]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of kinase activity [GO:0033673]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphorylation [GO:0042326]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron maturation [GO:0042551]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of exit from mitosis [GO:0007096]; regulation of lens fiber cell differentiation [GO:1902746]; skeletal system development [GO:0001501]; uterus development [GO:0060065]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P49959	reviewed	MRE11_HUMAN	Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)	MRE11 HNGS1 MRE11A	Homo sapiens (Human)	708	FUNCTION: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). RAD50 may be required to bind DNA ends and hold them in close proximity (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289, PubMed:30612738). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9705271}.	MISCELLANEOUS: In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells.	cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; homologous chromosome pairing at meiosis [GO:0007129]; homologous recombination [GO:0035825]; meiotic DNA double-strand break formation [GO:0042138]; mitochondrial double-strand break repair via homologous recombination [GO:0097552]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; negative regulation of apoptotic process [GO:0043066]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; reciprocal meiotic recombination [GO:0007131]; regulation of mitotic recombination [GO:0000019]; sister chromatid cohesion [GO:0007062]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomeric 3' overhang formation [GO:0031860]	BRCA1-C complex [GO:0070533]; chromosomal region [GO:0098687]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Mre11 complex [GO:0030870]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]	3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; 5'-3' exonuclease activity [GO:0008409]; cadherin binding [GO:0045296]; DNA endonuclease activity [GO:0004520]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; nuclease activity [GO:0004518]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]	BRCA1-C complex [GO:0070533]; chromosomal region [GO:0098687]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Mre11 complex [GO:0030870]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]; 3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; 5'-3' exonuclease activity [GO:0008409]; cadherin binding [GO:0045296]; DNA endonuclease activity [GO:0004520]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; nuclease activity [GO:0004518]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; homologous chromosome pairing at meiosis [GO:0007129]; homologous recombination [GO:0035825]; meiotic DNA double-strand break formation [GO:0042138]; mitochondrial double-strand break repair via homologous recombination [GO:0097552]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; negative regulation of apoptotic process [GO:0043066]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; reciprocal meiotic recombination [GO:0007131]; regulation of mitotic recombination [GO:0000019]; sister chromatid cohesion [GO:0007062]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomeric 3' overhang formation [GO:0031860]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10783165, ECO:0000269|PubMed:26215093}. Chromosome, telomere {ECO:0000269|PubMed:10888888}. Chromosome {ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:30612738}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000269|PubMed:10783165, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:30612738}.
P49961	reviewed	ENTP1_HUMAN	Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) (EC 3.6.1.5) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (CD antigen CD39)	ENTPD1 CD39	Homo sapiens (Human)	510	FUNCTION: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. {ECO:0000269|PubMed:8955160}.		blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; nucleoside diphosphate catabolic process [GO:0009134]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; UDP phosphatase activity [GO:0045134]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; UDP phosphatase activity [GO:0045134]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; nucleoside diphosphate catabolic process [GO:0009134]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P50052	reviewed	AGTR2_HUMAN	Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2 receptor)	AGTR2	Homo sapiens (Human)	363	FUNCTION: Receptor for angiotensin II, a vasoconstricting peptide (PubMed:8185599, PubMed:28379944, PubMed:29967536, PubMed:31899086). Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways (PubMed:28379944). Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15123706). {ECO:0000269|PubMed:15123706, ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:8185599}.		angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002033]; blood vessel remodeling [GO:0001974]; brain development [GO:0007420]; brain renin-angiotensin system [GO:0002035]; cell surface receptor signaling pathway [GO:0007166]; exploration behavior [GO:0035640]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [GO:0007199]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell growth [GO:0030308]; negative regulation of heart rate [GO:0010459]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; neuron apoptotic process [GO:0051402]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; regulation of blood pressure [GO:0008217]; regulation of metanephros size [GO:0035566]; regulation of systemic arterial blood pressure by circulatory renin-angiotensin [GO:0001991]; vasodilation [GO:0042311]	plasma membrane [GO:0005886]	angiotensin type II receptor activity [GO:0004945]; receptor antagonist activity [GO:0048019]	plasma membrane [GO:0005886]; angiotensin type II receptor activity [GO:0004945]; receptor antagonist activity [GO:0048019]; angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002033]; blood vessel remodeling [GO:0001974]; brain development [GO:0007420]; brain renin-angiotensin system [GO:0002035]; cell surface receptor signaling pathway [GO:0007166]; exploration behavior [GO:0035640]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [GO:0007199]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell growth [GO:0030308]; negative regulation of heart rate [GO:0010459]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; neuron apoptotic process [GO:0051402]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; regulation of blood pressure [GO:0008217]; regulation of metanephros size [GO:0035566]; regulation of systemic arterial blood pressure by circulatory renin-angiotensin [GO:0001991]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P35374}; Multi-pass membrane protein {ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569}.
P50053	reviewed	KHK_HUMAN	Ketohexokinase (EC 2.7.1.3) (Hepatic fructokinase)	KHK	Homo sapiens (Human)	298	FUNCTION: Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. {ECO:0000269|PubMed:12941785}.	MISCELLANEOUS: [Isoform A]: More widely distributed but with a low expression level. KM=7 mM for D-fructose (at 25 degrees Celsius). KM=036 mM for Mg-ATP (at 25 degrees Celsius). kcat is 6.9 sec(-1). {ECO:0000269|PubMed:12941785}.	fructose metabolic process [GO:0006000]; regulation of glycogen metabolic process [GO:0070873]; response to fructose [GO:0009750]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; response to sucrose [GO:0009744]; response to zinc ion [GO:0010043]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	ATP binding [GO:0005524]; ketohexokinase activity [GO:0004454]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; ketohexokinase activity [GO:0004454]; fructose metabolic process [GO:0006000]; regulation of glycogen metabolic process [GO:0070873]; response to fructose [GO:0009750]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; response to sucrose [GO:0009744]; response to zinc ion [GO:0010043]	
P50135	reviewed	HNMT_HUMAN	Histamine N-methyltransferase (HMT) (EC 2.1.1.8)	HNMT	Homo sapiens (Human)	292	FUNCTION: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. {ECO:0000269|PubMed:26206890}.	MISCELLANEOUS: [Isoform 2]: Has no histamine-methylating activity. {ECO:0000305}.	histamine catabolic process [GO:0001695]; histamine metabolic process [GO:0001692]; histidine catabolic process [GO:0006548]; methylation [GO:0032259]; respiratory gaseous exchange by respiratory system [GO:0007585]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	histamine N-methyltransferase activity [GO:0046539]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; histamine N-methyltransferase activity [GO:0046539]; histamine catabolic process [GO:0001695]; histamine metabolic process [GO:0001692]; histidine catabolic process [GO:0006548]; methylation [GO:0032259]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26206890}.
P50148	reviewed	GNAQ_HUMAN	Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)	GNAQ GAQ	Homo sapiens (Human)	359	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Required for platelet activation. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNA11, required for heart development (By similarity). {ECO:0000250|UniProtKB:P21279, ECO:0000269|PubMed:27852822}.		action potential [GO:0001508]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; blood coagulation [GO:0007596]; entrainment of circadian clock [GO:0009649]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; glutamate receptor signaling pathway [GO:0007215]; negative regulation of protein kinase activity [GO:0006469]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phototransduction, visible light [GO:0007603]; protein stabilization [GO:0050821]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of platelet activation [GO:0010543]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; nuclear membrane [GO:0031965]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; nuclear membrane [GO:0031965]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; action potential [GO:0001508]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; blood coagulation [GO:0007596]; entrainment of circadian clock [GO:0009649]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; glutamate receptor signaling pathway [GO:0007215]; negative regulation of protein kinase activity [GO:0006469]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phototransduction, visible light [GO:0007603]; protein stabilization [GO:0050821]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of platelet activation [GO:0010543]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19001095}; Lipid-anchor {ECO:0000269|PubMed:19001095}. Golgi apparatus {ECO:0000269|PubMed:19001095}. Nucleus {ECO:0000250|UniProtKB:P21279}. Nucleus membrane {ECO:0000250|UniProtKB:P21279}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250|UniProtKB:P21279}.
P50150	reviewed	GBG4_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	GNG4 GNGT4	Homo sapiens (Human)	75	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of cell growth [GO:0030308]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]	G-protein beta-subunit binding [GO:0031681]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; G-protein beta-subunit binding [GO:0031681]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of cell growth [GO:0030308]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P50151	reviewed	GBG10_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	GNG10 GNGT10	Homo sapiens (Human)	68	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.		G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]	heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]	G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]	heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P50213	reviewed	IDH3A_HUMAN	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)	IDH3A	Homo sapiens (Human)	366	FUNCTION: Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. {ECO:0000269|PubMed:28139779}.		carbohydrate metabolic process [GO:0005975]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099]	mitochondrial isocitrate dehydrogenase complex (NAD+) [GO:0005962]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]	mitochondrial isocitrate dehydrogenase complex (NAD+) [GO:0005962]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; carbohydrate metabolic process [GO:0005975]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion.
P50219	reviewed	MNX1_HUMAN	Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9)	MNX1 HLXB9	Homo sapiens (Human)	401	FUNCTION: Transcription factor (By similarity). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity). {ECO:0000250|UniProtKB:Q9QZW9}.		central nervous system development [GO:0007417]; endocrine pancreas development [GO:0031018]; neuron projection morphogenesis [GO:0048812]; spinal cord motor neuron cell fate specification [GO:0021520]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific double-stranded DNA binding [GO:1990837]; central nervous system development [GO:0007417]; endocrine pancreas development [GO:0031018]; neuron projection morphogenesis [GO:0048812]; spinal cord motor neuron cell fate specification [GO:0021520]	SUBCELLULAR LOCATION: Nucleus.
P50221	reviewed	MEOX1_HUMAN	Homeobox protein MOX-1 (Mesenchyme homeobox 1)	MEOX1 MOX1	Homo sapiens (Human)	254	FUNCTION: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. {ECO:0000250|UniProtKB:F1Q4R9, ECO:0000250|UniProtKB:P32442, ECO:0000269|PubMed:23290072, ECO:0000269|PubMed:24073994}.		hematopoietic stem cell differentiation [GO:0060218]; regulation of transcription by RNA polymerase II [GO:0006357]; sclerotome development [GO:0061056]; somite development [GO:0061053]; somite specification [GO:0001757]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; hematopoietic stem cell differentiation [GO:0060218]; regulation of transcription by RNA polymerase II [GO:0006357]; sclerotome development [GO:0061056]; somite development [GO:0061053]; somite specification [GO:0001757]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P32442}. Cytoplasm {ECO:0000250|UniProtKB:P32442}. Note=Localizes predominantly in the nucleus. {ECO:0000250|UniProtKB:P32442}.
P50222	reviewed	MEOX2_HUMAN	Homeobox protein MOX-2 (Growth arrest-specific homeobox) (Mesenchyme homeobox 2)	MEOX2 GAX MOX2	Homo sapiens (Human)	304	FUNCTION: Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity). {ECO:0000250|UniProtKB:P32443, ECO:0000250|UniProtKB:P39020, ECO:0000269|PubMed:17074759, ECO:0000269|PubMed:20516212, ECO:0000269|PubMed:22206000}.		angiogenesis [GO:0001525]; limb development [GO:0060173]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal muscle tissue development [GO:0007519]; somite development [GO:0061053]; somite specification [GO:0001757]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; angiogenesis [GO:0001525]; limb development [GO:0060173]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal muscle tissue development [GO:0007519]; somite development [GO:0061053]; somite specification [GO:0001757]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19266028, ECO:0000269|PubMed:22206000}. Nucleus speckle {ECO:0000269|PubMed:19266028}.
P50225	reviewed	ST1A1_HUMAN	Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST)	SULT1A1 STP STP1 OK/SW-cl.88	Homo sapiens (Human)	295	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (PubMed:16221673, PubMed:12471039, PubMed:22069470, PubMed:21723874, PubMed:10199779, PubMed:7834621). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:7834621). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. {ECO:0000250|UniProtKB:P17988, ECO:0000269|PubMed:10199779, ECO:0000269|PubMed:12471039, ECO:0000269|PubMed:16221673, ECO:0000269|PubMed:21723874, ECO:0000269|PubMed:22069470, ECO:0000269|PubMed:35165440, ECO:0000269|PubMed:7834621}.		3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine metabolic process [GO:0009308]; catecholamine metabolic process [GO:0006584]; estrogen metabolic process [GO:0008210]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; aryl sulfotransferase activity [GO:0004062]; flavonol 3-sulfotransferase activity [GO:0047894]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; aryl sulfotransferase activity [GO:0004062]; flavonol 3-sulfotransferase activity [GO:0047894]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine metabolic process [GO:0009308]; catecholamine metabolic process [GO:0006584]; estrogen metabolic process [GO:0008210]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P17988}.
P50226	reviewed	ST1A2_HUMAN	Sulfotransferase 1A2 (ST1A2) (EC 2.8.2.1) (Aryl sulfotransferase 2) (Phenol sulfotransferase 2) (Phenol-sulfating phenol sulfotransferase 2) (P-PST 2)	SULT1A2 STP2	Homo sapiens (Human)	295	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.		3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine biosynthetic process [GO:0009309]; catecholamine metabolic process [GO:0006584]; ethanol catabolic process [GO:0006068]; phenol-containing compound metabolic process [GO:0018958]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	aryl sulfotransferase activity [GO:0004062]; flavonol 3-sulfotransferase activity [GO:0047894]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; flavonol 3-sulfotransferase activity [GO:0047894]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine biosynthetic process [GO:0009309]; catecholamine metabolic process [GO:0006584]; ethanol catabolic process [GO:0006068]; phenol-containing compound metabolic process [GO:0018958]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm.
P50238	reviewed	CRIP1_HUMAN	Cysteine-rich protein 1 (CRP-1) (Cysteine-rich heart protein) (CRHP) (hCRHP) (Cysteine-rich intestinal protein) (CRIP)	CRIP1 CRIP CRP1	Homo sapiens (Human)	77	FUNCTION: Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.		cellular response to antibiotic [GO:0071236]; cellular response to UV-B [GO:0071493]; heart development [GO:0007507]; immune response [GO:0006955]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; prostate gland stromal morphogenesis [GO:0060741]; regulation of gene expression [GO:0010468]; response to organic substance [GO:0010033]; response to zinc ion [GO:0010043]	cytoplasm [GO:0005737]	peptide binding [GO:0042277]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]; cellular response to antibiotic [GO:0071236]; cellular response to UV-B [GO:0071493]; heart development [GO:0007507]; immune response [GO:0006955]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; prostate gland stromal morphogenesis [GO:0060741]; regulation of gene expression [GO:0010468]; response to organic substance [GO:0010033]; response to zinc ion [GO:0010043]	
P50281	reviewed	MMP14_HUMAN	Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)	MMP14	Homo sapiens (Human)	582	FUNCTION: Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). {ECO:0000250|UniProtKB:P53690, ECO:0000269|PubMed:12714657, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:22330140}.		angiogenesis [GO:0001525]; astrocyte cell migration [GO:0043615]; branching morphogenesis of an epithelial tube [GO:0048754]; cell motility [GO:0048870]; chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; endodermal cell differentiation [GO:0035987]; endothelial cell proliferation [GO:0001935]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; head development [GO:0060322]; lung development [GO:0030324]; male gonad development [GO:0008584]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of Notch signaling pathway [GO:0045746]; ovarian follicle development [GO:0001541]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of macrophage migration [GO:1905523]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of protein processing [GO:0010954]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of protein localization to plasma membrane [GO:1903076]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to odorant [GO:1990834]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; skeletal system development [GO:0001501]; tissue remodeling [GO:0048771]; zymogen activation [GO:0031638]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; intermediate filament cytoskeleton [GO:0045111]; macropinosome [GO:0044354]; melanosome [GO:0042470]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; intermediate filament cytoskeleton [GO:0045111]; macropinosome [GO:0044354]; melanosome [GO:0042470]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; angiogenesis [GO:0001525]; astrocyte cell migration [GO:0043615]; branching morphogenesis of an epithelial tube [GO:0048754]; cell motility [GO:0048870]; chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; endodermal cell differentiation [GO:0035987]; endothelial cell proliferation [GO:0001935]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; head development [GO:0060322]; lung development [GO:0030324]; male gonad development [GO:0008584]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of Notch signaling pathway [GO:0045746]; ovarian follicle development [GO:0001541]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of macrophage migration [GO:1905523]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of protein processing [GO:0010954]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of protein localization to plasma membrane [GO:1903076]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to odorant [GO:1990834]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; skeletal system development [GO:0001501]; tissue remodeling [GO:0048771]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
P50336	reviewed	PPOX_HUMAN	Protoporphyrinogen oxidase (PPO) (EC 1.3.3.4)	PPOX	Homo sapiens (Human)	477	FUNCTION: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. {ECO:0000269|PubMed:21048046, ECO:0000269|PubMed:23467411, ECO:0000269|PubMed:7713909}.		heme biosynthetic process [GO:0006783]; porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process [GO:0006782]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]	flavin adenine dinucleotide binding [GO:0050660]; oxygen-dependent protoporphyrinogen oxidase activity [GO:0004729]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; flavin adenine dinucleotide binding [GO:0050660]; oxygen-dependent protoporphyrinogen oxidase activity [GO:0004729]; heme biosynthetic process [GO:0006783]; porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process [GO:0006782]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Intermembrane side {ECO:0000250}.
P50391	reviewed	NPY4R_HUMAN	Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide receptor 1) (PP1)	NPY4R PPYR1	Homo sapiens (Human)	375	FUNCTION: G protein-coupled receptor for PPY/pancreatic polypeptide/PP, NPY/neuropeptide Y and PYY/peptide YY that is negatively coupled to cAMP (PubMed:7592911, PubMed:7493937). The rank order of affinity for these polypeptides and their derivatives is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid. {ECO:0000269|PubMed:7493937, ECO:0000269|PubMed:7592911}.		G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; pancreatic polypeptide receptor activity [GO:0001602]; peptide hormone binding [GO:0017046]	membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; pancreatic polypeptide receptor activity [GO:0001602]; peptide hormone binding [GO:0017046]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7493937, ECO:0000269|PubMed:7592911}; Multi-pass membrane protein {ECO:0000255}.
P50395	reviewed	GDIB_HUMAN	Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)	GDI2 RABGDIB	Homo sapiens (Human)	445	FUNCTION: GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}.		negative regulation of cilium assembly [GO:1902018]; negative regulation of protein localization to cilium [GO:1903565]; protein transport [GO:0015031]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]; synapse [GO:0045202]; vesicle [GO:0031982]	GTPase activator activity [GO:0005096]; Rab GDP-dissociation inhibitor activity [GO:0005093]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]; synapse [GO:0045202]; vesicle [GO:0031982]; GTPase activator activity [GO:0005096]; Rab GDP-dissociation inhibitor activity [GO:0005093]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; negative regulation of cilium assembly [GO:1902018]; negative regulation of protein localization to cilium [GO:1903565]; protein transport [GO:0015031]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
P50402	reviewed	EMD_HUMAN	Emerin	EMD EDMD STA	Homo sapiens (Human)	254	FUNCTION: Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}.		cellular response to growth factor stimulus [GO:0071363]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fibroblast proliferation [GO:0048147]; nuclear membrane organization [GO:0071763]; positive regulation of protein export from nucleus [GO:0046827]; regulation of canonical Wnt signaling pathway [GO:0060828]; skeletal muscle cell differentiation [GO:0035914]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; TMEM240-body [GO:0160045]	actin binding [GO:0003779]; beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; TMEM240-body [GO:0160045]; actin binding [GO:0003779]; beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296]; cellular response to growth factor stimulus [GO:0071363]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fibroblast proliferation [GO:0048147]; nuclear membrane organization [GO:0071763]; positive regulation of protein export from nucleus [GO:0046827]; regulation of canonical Wnt signaling pathway [GO:0060828]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:19167377}; Single-pass membrane protein; Nucleoplasmic side {ECO:0000269|PubMed:19167377}. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
P50406	reviewed	5HT6R_HUMAN	5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (Serotonin receptor 6)	HTR6	Homo sapiens (Human)	440	FUNCTION: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:23027611}.		cerebral cortex cell migration [GO:0021795]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; positive regulation of TOR signaling [GO:0032008]	cilium [GO:0005929]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594]	cilium [GO:0005929]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594]; cerebral cortex cell migration [GO:0021795]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; positive regulation of TOR signaling [GO:0032008]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P50416	reviewed	CPT1A_HUMAN	Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)	CPT1A CPT1	Homo sapiens (Human)	773	FUNCTION: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:9691089, PubMed:11350182, PubMed:14517221). Plays an important role in hepatic triglyceride metabolism (By similarity). {ECO:0000250|UniProtKB:P32198, ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221, ECO:0000269|PubMed:9691089}.		carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; cellular response to fatty acid [GO:0071398]; eating behavior [GO:0042755]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; glucose metabolic process [GO:0006006]; liver regeneration [GO:0097421]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of fatty acid beta-oxidation [GO:0032000]; regulation of insulin secretion [GO:0050796]; regulation of lipid storage [GO:0010883]; response to alkaloid [GO:0043279]; response to ethanol [GO:0045471]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; response to tetrachloromethane [GO:1904772]; response to xenobiotic stimulus [GO:0009410]; triglyceride metabolic process [GO:0006641]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	carnitine O-palmitoyltransferase activity [GO:0004095]; identical protein binding [GO:0042802]; palmitoleoyltransferase activity [GO:1990698]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; carnitine O-palmitoyltransferase activity [GO:0004095]; identical protein binding [GO:0042802]; palmitoleoyltransferase activity [GO:1990698]; carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; cellular response to fatty acid [GO:0071398]; eating behavior [GO:0042755]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; glucose metabolic process [GO:0006006]; liver regeneration [GO:0097421]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of fatty acid beta-oxidation [GO:0032000]; regulation of insulin secretion [GO:0050796]; regulation of lipid storage [GO:0010883]; response to alkaloid [GO:0043279]; response to ethanol [GO:0045471]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; response to tetrachloromethane [GO:1904772]; response to xenobiotic stimulus [GO:0009410]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221}; Multi-pass membrane protein {ECO:0000255}.
P50440	reviewed	GATM_HUMAN	Glycine amidinotransferase, mitochondrial (EC 2.1.4.1) (L-arginine:glycine amidinotransferase) (Transamidinase)	GATM AGAT	Homo sapiens (Human)	423	FUNCTION: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives (PubMed:3800397, PubMed:16820567, PubMed:36543883, PubMed:27233232). Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (PubMed:3800397, PubMed:36543883, PubMed:9266688, PubMed:27233232) (Probable). {ECO:0000269|PubMed:16820567, ECO:0000269|PubMed:27233232, ECO:0000269|PubMed:36543883, ECO:0000269|PubMed:3800397, ECO:0000269|PubMed:9266688, ECO:0000305|PubMed:16820567}.		creatine biosynthetic process [GO:0006601]; creatine metabolic process [GO:0006600]; learning or memory [GO:0007611]; muscle atrophy [GO:0014889]; positive regulation of cold-induced thermogenesis [GO:0120162]	extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]	amidinotransferase activity [GO:0015067]; glycine amidinotransferase activity [GO:0015068]	extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; amidinotransferase activity [GO:0015067]; glycine amidinotransferase activity [GO:0015068]; creatine biosynthetic process [GO:0006601]; creatine metabolic process [GO:0006600]; learning or memory [GO:0007611]; muscle atrophy [GO:0014889]; positive regulation of cold-induced thermogenesis [GO:0120162]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Probably attached to the outer side of the inner membrane.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
P50443	reviewed	S26A2_HUMAN	Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2)	SLC26A2 DTD DTDST	Homo sapiens (Human)	739	FUNCTION: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:7923357, PubMed:11448940, PubMed:15294877, PubMed:20219950). Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions (PubMed:20219950). Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity). {ECO:0000250|UniProtKB:Q62273, ECO:0000269|PubMed:11448940, ECO:0000269|PubMed:15294877, ECO:0000269|PubMed:20219950, ECO:0000269|PubMed:7923357}.		chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; ossification [GO:0001503]; sulfate transmembrane transport [GO:1902358]; sulfate transport [GO:0008272]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; ossification [GO:0001503]; sulfate transmembrane transport [GO:1902358]; sulfate transport [GO:0008272]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15294877, ECO:0000269|PubMed:7923357}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O70531}; Multi-pass membrane protein {ECO:0000255}.
P50452	reviewed	SPB8_HUMAN	Serpin B8 (Cytoplasmic antiproteinase 2) (CAP-2) (CAP2) (Peptidase inhibitor 8) (PI-8)	SERPINB8 PI8	Homo sapiens (Human)	374	FUNCTION: Has an important role in epithelial desmosome-mediated cell-cell adhesion. {ECO:0000269|PubMed:27476651}.		epithelial cell-cell adhesion [GO:0090136]; negative regulation of endopeptidase activity [GO:0010951]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; epithelial cell-cell adhesion [GO:0090136]; negative regulation of endopeptidase activity [GO:0010951]	SUBCELLULAR LOCATION: Cytoplasm.
P50453	reviewed	SPB9_HUMAN	Serpin B9 (Cytoplasmic antiproteinase 3) (CAP-3) (CAP3) (Peptidase inhibitor 9) (PI-9)	SERPINB9 PI9	Homo sapiens (Human)	376	FUNCTION: Granzyme B inhibitor.		cellular response to estrogen stimulus [GO:0071391]; immune response [GO:0006955]; mast cell mediated immunity [GO:0002448]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endopeptidase activity [GO:0010951]; protection from natural killer cell mediated cytotoxicity [GO:0042270]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; cellular response to estrogen stimulus [GO:0071391]; immune response [GO:0006955]; mast cell mediated immunity [GO:0002448]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endopeptidase activity [GO:0010951]; protection from natural killer cell mediated cytotoxicity [GO:0042270]	SUBCELLULAR LOCATION: Cytoplasm.
P50454	reviewed	SERPH_HUMAN	Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47)	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	Homo sapiens (Human)	418	FUNCTION: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.		chondrocyte development involved in endochondral bone morphogenesis [GO:0003433]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; protein maturation [GO:0051604]; response to unfolded protein [GO:0006986]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular space [GO:0005615]; membrane raft [GO:0045121]	collagen binding [GO:0005518]; RNA binding [GO:0003723]; serine-type endopeptidase inhibitor activity [GO:0004867]; unfolded protein binding [GO:0051082]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; collagen binding [GO:0005518]; RNA binding [GO:0003723]; serine-type endopeptidase inhibitor activity [GO:0004867]; unfolded protein binding [GO:0051082]; chondrocyte development involved in endochondral bone morphogenesis [GO:0003433]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; protein maturation [GO:0051604]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
P50458	reviewed	LHX2_HUMAN	LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2)	LHX2 LH2	Homo sapiens (Human)	406	FUNCTION: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). {ECO:0000250}.		axon extension [GO:0048675]; axon guidance [GO:0007411]; cerebral cortex development [GO:0021987]; dorsal/ventral pattern formation [GO:0009953]; hair follicle development [GO:0001942]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesoderm development [GO:0007498]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of neurogenesis [GO:0050768]; neural tube closure [GO:0001843]; neuron differentiation [GO:0030182]; olfactory bulb development [GO:0021772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neural precursor cell proliferation [GO:2000179]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; telencephalon regionalization [GO:0021978]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; axon extension [GO:0048675]; axon guidance [GO:0007411]; cerebral cortex development [GO:0021987]; dorsal/ventral pattern formation [GO:0009953]; hair follicle development [GO:0001942]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesoderm development [GO:0007498]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of neurogenesis [GO:0050768]; neural tube closure [GO:0001843]; neuron differentiation [GO:0030182]; olfactory bulb development [GO:0021772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neural precursor cell proliferation [GO:2000179]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; telencephalon regionalization [GO:0021978]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P50461	reviewed	CSRP3_HUMAN	Cysteine and glycine-rich protein 3 (Cardiac LIM protein) (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein)	CSRP3 CLP MLP	Homo sapiens (Human)	194	FUNCTION: Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). {ECO:0000250|UniProtKB:P50462, ECO:0000250|UniProtKB:P50463, ECO:0000269|PubMed:19752190, ECO:0000269|PubMed:24934443, ECO:0000269|PubMed:27353086}.; FUNCTION: [Isoform 2]: May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization. {ECO:0000269|PubMed:24860983}.		cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue development [GO:0048738]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; glucose homeostasis [GO:0042593]; inflammatory response [GO:0006954]; insulin receptor signaling pathway [GO:0008286]; intracellular calcium ion homeostasis [GO:0006874]; muscle cell cellular homeostasis [GO:0046716]; muscle tissue development [GO:0060537]; negative regulation of actin filament severing [GO:1903919]; negative regulation of myoblast differentiation [GO:0045662]; positive regulation of actin filament severing [GO:1903920]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein kinase C signaling [GO:0070528]; protein localization to organelle [GO:0033365]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of the force of heart contraction [GO:0002026]; sarcomere organization [GO:0045214]; skeletal muscle tissue development [GO:0007519]; T-tubule organization [GO:0033292]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Z disc [GO:0030018]	actin binding [GO:0003779]; actinin binding [GO:0042805]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; structural constituent of muscle [GO:0008307]; telethonin binding [GO:0031433]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Z disc [GO:0030018]; actin binding [GO:0003779]; actinin binding [GO:0042805]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; structural constituent of muscle [GO:0008307]; telethonin binding [GO:0031433]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue development [GO:0048738]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; glucose homeostasis [GO:0042593]; inflammatory response [GO:0006954]; insulin receptor signaling pathway [GO:0008286]; intracellular calcium ion homeostasis [GO:0006874]; muscle cell cellular homeostasis [GO:0046716]; muscle tissue development [GO:0060537]; negative regulation of actin filament severing [GO:1903919]; negative regulation of myoblast differentiation [GO:0045662]; positive regulation of actin filament severing [GO:1903920]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein kinase C signaling [GO:0070528]; protein localization to organelle [GO:0033365]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of the force of heart contraction [GO:0002026]; sarcomere organization [GO:0045214]; skeletal muscle tissue development [GO:0007519]; T-tubule organization [GO:0033292]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P50463}. Cytoplasm {ECO:0000269|PubMed:18505755}. Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:24860983}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:24934443}. Note=Nucleocytoplasmic shuttling protein. Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity). {ECO:0000250|UniProtKB:P50462, ECO:0000250|UniProtKB:P50463}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:24860983}.
P50479	reviewed	PDLI4_HUMAN	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein)	PDLIM4 RIL	Homo sapiens (Human)	330	FUNCTION: [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). {ECO:0000250|UniProtKB:P36202, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:21636573}.; FUNCTION: [Isoform 2]: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. {ECO:0000269|PubMed:21636573}.		actin cytoskeleton organization [GO:0030036]; excitatory chemical synaptic transmission [GO:0098976]; heart development [GO:0007507]; muscle structure development [GO:0061061]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; early endosome lumen [GO:0031905]; early endosome membrane [GO:0031901]; filamentous actin [GO:0031941]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic membrane [GO:0045211]; recycling endosome lumen [GO:0034777]; recycling endosome membrane [GO:0055038]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; early endosome lumen [GO:0031905]; early endosome membrane [GO:0031901]; filamentous actin [GO:0031941]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic membrane [GO:0045211]; recycling endosome lumen [GO:0034777]; recycling endosome membrane [GO:0055038]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; actin cytoskeleton organization [GO:0030036]; excitatory chemical synaptic transmission [GO:0098976]; heart development [GO:0007507]; muscle structure development [GO:0061061]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21636573}. Nucleus {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:21636573}. Cytoplasm {ECO:0000269|PubMed:21636573}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19307596}. Cell projection, lamellipodium {ECO:0000269|PubMed:10826496}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P36202}. Early endosome membrane {ECO:0000250|UniProtKB:P36202}; Peripheral membrane protein {ECO:0000250|UniProtKB:P36202}; Cytoplasmic side {ECO:0000250|UniProtKB:P36202}. Recycling endosome membrane {ECO:0000250|UniProtKB:P36202}; Peripheral membrane protein {ECO:0000250|UniProtKB:P36202}; Cytoplasmic side {ECO:0000250|UniProtKB:P36202}. Synapse, synaptosome {ECO:0000250|UniProtKB:P36202}. Note=Localizes to actin stress fibers in nonmuscle cells. Colocalizes with GRIA1 in early endosomes. Enriched in numerous but not all spine-like structures along dendritic branches. Colocalizes with actin and enriched at sites containing larger amounts of actin and alpha-actinin. Targeted efficiently to spines via its PDZ domain-mediated interaction with the alpha-actinin/actin cytoskeletal complex. Localizes to synaptosomes in brain (By similarity). Colocalizes with F-actin (PubMed:10826496). Colocalizes with TRIP6 at cell-cell contacts and lamellipodia (PubMed:10826496). In the cytoplasm, displays a fibrillar pattern with characteristic thick fibers and occasional clusters. Colocalizes with the actin stress fibers. Oxidative stress induces redistribution from cytoskeleton to cytosol (PubMed:21636573). Colocalizes with SRC at the perinuclear region, but not at focal adhesions (PubMed:19307596). {ECO:0000250|UniProtKB:P36202, ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:21636573}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:21636573}. Note=Stains more diffusely in the cytoplasm with thin fibers forming a dense mesh-like pattern. {ECO:0000269|PubMed:21636573}.
P50502	reviewed	F10A1_HUMAN	Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein)	ST13 AAG2 FAM10A1 HIP SNC6	Homo sapiens (Human)	369	FUNCTION: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}.		chaperone cofactor-dependent protein refolding [GO:0051085]; protein folding [GO:0006457]; response to bacterium [GO:0009617]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	Hsp70 protein binding [GO:0030544]; protein dimerization activity [GO:0046983]; protein-macromolecule adaptor activity [GO:0030674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Hsp70 protein binding [GO:0030544]; protein dimerization activity [GO:0046983]; protein-macromolecule adaptor activity [GO:0030674]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein folding [GO:0006457]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
P50539	reviewed	MXI1_HUMAN	Max-interacting protein 1 (Max interactor 1) (Class C basic helix-loop-helix protein 11) (bHLHc11)	MXI1 BHLHC11	Homo sapiens (Human)	228	FUNCTION: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P50542	reviewed	PEX5_HUMAN	Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)	PEX5 PXR1	Homo sapiens (Human)	639	FUNCTION: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:7706321, PubMed:7719337, PubMed:7790377, PubMed:11336669, PubMed:12456682, PubMed:16314507, PubMed:21976670, PubMed:26344566, PubMed:11101887, PubMed:17157249, PubMed:17428317). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:12456682, PubMed:21976670, PubMed:26344566, PubMed:17157249). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:11336669, PubMed:24662292). {ECO:0000269|PubMed:11101887, ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:12456682, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:17157249, ECO:0000269|PubMed:17428317, ECO:0000269|PubMed:21976670, ECO:0000269|PubMed:24662292, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:7706321, ECO:0000269|PubMed:7719337, ECO:0000269|PubMed:7790377}.; FUNCTION: [Isoform 1]: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (PubMed:9668159, PubMed:11336669, PubMed:11546814, PubMed:25538232, PubMed:33389129). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (PubMed:25538232). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5 (PubMed:25538232). {ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:11546814, ECO:0000269|PubMed:25538232, ECO:0000269|PubMed:33389129, ECO:0000269|PubMed:9668159}.; FUNCTION: [Isoform 2]: Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. {ECO:0000269|PubMed:11546814}.		cell development [GO:0048468]; cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; cerebral cortex neuron differentiation [GO:0021895]; endoplasmic reticulum organization [GO:0007029]; fatty acid beta-oxidation [GO:0006635]; mitochondrial membrane organization [GO:0007006]; negative regulation of protein-containing complex assembly [GO:0031333]; neuromuscular process [GO:0050905]; neuron migration [GO:0001764]; pexophagy [GO:0000425]; positive regulation of multicellular organism growth [GO:0040018]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; protein tetramerization [GO:0051262]; very long-chain fatty acid metabolic process [GO:0000038]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	enzyme binding [GO:0019899]; peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome membrane targeting sequence binding [GO:0033328]; peroxisome targeting sequence binding [GO:0000268]; protein carrier chaperone [GO:0140597]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; enzyme binding [GO:0019899]; peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome membrane targeting sequence binding [GO:0033328]; peroxisome targeting sequence binding [GO:0000268]; protein carrier chaperone [GO:0140597]; small GTPase binding [GO:0031267]; cell development [GO:0048468]; cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; cerebral cortex neuron differentiation [GO:0021895]; endoplasmic reticulum organization [GO:0007029]; fatty acid beta-oxidation [GO:0006635]; mitochondrial membrane organization [GO:0007006]; negative regulation of protein-containing complex assembly [GO:0031333]; neuromuscular process [GO:0050905]; neuron migration [GO:0001764]; pexophagy [GO:0000425]; positive regulation of multicellular organism growth [GO:0040018]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; protein tetramerization [GO:0051262]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:7719337}. Peroxisome matrix {ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:11546814, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:24662292, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:33389129, ECO:0000269|PubMed:7706321, ECO:0000269|PubMed:7719337}. Note=Cycles between the cytosol and the peroxisome matrix (PubMed:11336669, PubMed:16314507). Following binding to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, recruited to the docking complex, composed of PEX13 and PEX14, leading to translocation into the peroxisome matrix along with cargo proteins (By similarity). Export and recycling to the cytosol is initiated by binding to the PEX2-PEX10-PEX12 ligase complex via its unstructured N-terminus that inserts into the ligase pore and emerges in the cytosol (By similarity). Cys-11 of PEX5 is then monoubiquitinated, promoting its extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex (PubMed:16314507, PubMed:19208625, PubMed:24118911, PubMed:29884772). Extraction is accompanied by unfolding of the TPR repeats and release of bound cargo in the peroxisome matrix (By similarity). The TPR repeats refold in the cytosol and ubiquitination is removed by deubiquitinating enzymes, resetting PEX5 for a subsequent import cycle (By similarity). {ECO:0000250|UniProtKB:A0A1L8FDW4, ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:19208625, ECO:0000269|PubMed:24118911, ECO:0000269|PubMed:29884772}.
P50548	reviewed	ERF_HUMAN	ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2)	ERF	Homo sapiens (Human)	548	FUNCTION: Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P50549	reviewed	ETV1_HUMAN	ETS translocation variant 1 (Ets-related protein 81)	ETV1 ER81	Homo sapiens (Human)	477	FUNCTION: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}.		axon guidance [GO:0007411]; mechanosensory behavior [GO:0007638]; muscle organ development [GO:0007517]; peripheral nervous system neuron development [GO:0048935]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; axon guidance [GO:0007411]; mechanosensory behavior [GO:0007638]; muscle organ development [GO:0007517]; peripheral nervous system neuron development [GO:0048935]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
P50552	reviewed	VASP_HUMAN	Vasodilator-stimulated phosphoprotein (VASP)	VASP	Homo sapiens (Human)	380	FUNCTION: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. {ECO:0000269|PubMed:10087267, ECO:0000269|PubMed:10438535, ECO:0000269|PubMed:15939738, ECO:0000269|PubMed:17082196, ECO:0000269|PubMed:18559661}.	MISCELLANEOUS: VASP phosphorylation is used to monitor the effect of so-called antiplatelet drugs that reduce platelet reactivity and are used to prevent stent thrombosis, strokes and heart attacks in patients at risk for these problems.	actin cytoskeleton organization [GO:0030036]; actin polymerization or depolymerization [GO:0008154]; axon guidance [GO:0007411]; neural tube closure [GO:0001843]; positive regulation of actin filament polymerization [GO:0030838]; protein homotetramerization [GO:0051289]	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; cadherin binding [GO:0045296]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124]	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124]; actin cytoskeleton organization [GO:0030036]; actin polymerization or depolymerization [GO:0008154]; axon guidance [GO:0007411]; neural tube closure [GO:0001843]; positive regulation of actin filament polymerization [GO:0030838]; protein homotetramerization [GO:0051289]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction {ECO:0000250}. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).
P50553	reviewed	ASCL1_HUMAN	Achaete-scute homolog 1 (ASH-1) (hASH1) (Class A basic helix-loop-helix protein 46) (bHLHa46)	ASCL1 ASH1 BHLHA46 HASH1	Homo sapiens (Human)	236	FUNCTION: Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity). {ECO:0000250|UniProtKB:Q02067}.		adrenal chromaffin cell differentiation [GO:0061104]; carotid body glomus cell differentiation [GO:0061103]; cell maturation [GO:0048469]; cellular response to magnetism [GO:0071259]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; cerebral cortex GABAergic interneuron differentiation [GO:0021892]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; heart development [GO:0007507]; lung epithelial cell differentiation [GO:0060487]; lung neuroendocrine cell differentiation [GO:0061100]; motor neuron migration [GO:0097475]; musculoskeletal movement, spinal reflex action [GO:0050883]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast fate determination [GO:0007400]; neuroblast proliferation [GO:0007405]; neurogenesis [GO:0022008]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; noradrenergic neuron development [GO:0003358]; noradrenergic neuron fate commitment [GO:0003359]; Notch signaling pathway [GO:0007219]; olfactory pit development [GO:0060166]; oligodendrocyte development [GO:0014003]; peripheral nervous system neuron development [GO:0048935]; positive regulation of cell cycle [GO:0045787]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epithelial cell differentiation [GO:0030856]; regulation of gene expression [GO:0010468]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of timing of subpallium neuron differentiation [GO:0060165]; response to epidermal growth factor [GO:0070849]; response to folic acid [GO:0051593]; response to retinoic acid [GO:0032526]; sensory organ development [GO:0007423]; spinal cord association neuron differentiation [GO:0021527]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; stomach neuroendocrine cell differentiation [GO:0061102]; subpallium neuron fate commitment [GO:0060163]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]; ventral spinal cord interneuron fate commitment [GO:0060579]; vestibular nucleus development [GO:0021750]	chromatin [GO:0000785]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	bHLH transcription factor binding [GO:0043425]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; bHLH transcription factor binding [GO:0043425]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; adrenal chromaffin cell differentiation [GO:0061104]; carotid body glomus cell differentiation [GO:0061103]; cell maturation [GO:0048469]; cellular response to magnetism [GO:0071259]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; cerebral cortex GABAergic interneuron differentiation [GO:0021892]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; heart development [GO:0007507]; lung epithelial cell differentiation [GO:0060487]; lung neuroendocrine cell differentiation [GO:0061100]; motor neuron migration [GO:0097475]; musculoskeletal movement, spinal reflex action [GO:0050883]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast fate determination [GO:0007400]; neuroblast proliferation [GO:0007405]; neurogenesis [GO:0022008]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; noradrenergic neuron development [GO:0003358]; noradrenergic neuron fate commitment [GO:0003359]; Notch signaling pathway [GO:0007219]; olfactory pit development [GO:0060166]; oligodendrocyte development [GO:0014003]; peripheral nervous system neuron development [GO:0048935]; positive regulation of cell cycle [GO:0045787]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epithelial cell differentiation [GO:0030856]; regulation of gene expression [GO:0010468]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of timing of subpallium neuron differentiation [GO:0060165]; response to epidermal growth factor [GO:0070849]; response to folic acid [GO:0051593]; response to retinoic acid [GO:0032526]; sensory organ development [GO:0007423]; spinal cord association neuron differentiation [GO:0021527]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; stomach neuroendocrine cell differentiation [GO:0061102]; subpallium neuron fate commitment [GO:0060163]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]; ventral spinal cord interneuron fate commitment [GO:0060579]; vestibular nucleus development [GO:0021750]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02067}.
P50570	reviewed	DYN2_HUMAN	Dynamin-2 (EC 3.6.5.5)	DNM2 DYN2	Homo sapiens (Human)	870	FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis (PubMed:33713620). Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685, ECO:0000269|PubMed:33713620}.	MISCELLANEOUS: Overexpression of CNM- and CMT-related DNM2 mutants in COS7 cells, whatever the mutated domain, led to a reduction in clathrin-mediated receptor endocytosis associated with MAPK ERK-1 and ERK-2 impairment. The membrane trafficking impairment process may represent a common pathophysiological pathway in the autosomal forms of CNM DNM2-CMT neuropathy.	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; endocytosis [GO:0006897]; G2/M transition of mitotic cell cycle [GO:0000086]; membrane organization [GO:0061024]; negative regulation of membrane tubulation [GO:1903526]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; post-Golgi vesicle-mediated transport [GO:0006892]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of axon extension [GO:0030516]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle transport [GO:0048489]; transferrin transport [GO:0033572]	cell projection [GO:0042995]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; microtubule [GO:0005874]; midbody [GO:0030496]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]	enzyme binding [GO:0019899]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; SH3 domain binding [GO:0017124]	cell projection [GO:0042995]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; microtubule [GO:0005874]; midbody [GO:0030496]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; enzyme binding [GO:0019899]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; SH3 domain binding [GO:0017124]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; endocytosis [GO:0006897]; G2/M transition of mitotic cell cycle [GO:0000086]; membrane organization [GO:0061024]; negative regulation of membrane tubulation [GO:1903526]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; post-Golgi vesicle-mediated transport [GO:0006892]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of axon extension [GO:0030516]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle transport [GO:0048489]; transferrin transport [GO:0033572]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction {ECO:0000250|UniProtKB:P39052}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:P39052}. Postsynaptic density. Synapse. Midbody. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:P39054}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:P39054}; Peripheral membrane protein {ECO:0000250|UniProtKB:P39054}. Note=Colocalizes with CTTN at the basis of filopodia in hippocampus neuron growth zones (By similarity). Microtubule-associated. Also found in the postsynaptic density of neuronal cells. Co-localizes with PIK3C3 and RAB5A to the nascent phagosome (By similarity). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054}.
P50579	reviewed	MAP2_HUMAN	Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M)	METAP2 MNPEP P67EIF2	Homo sapiens (Human)	478	FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.		N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; protein processing [GO:0016485]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	aminopeptidase activity [GO:0004177]; initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; aminopeptidase activity [GO:0004177]; initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; RNA binding [GO:0003723]; N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes.
P50583	reviewed	AP4A_HUMAN	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (EC 3.6.1.17) (Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase) (Ap4A hydrolase) (Ap4Aase) (Diadenosine tetraphosphatase) (Nucleoside diphosphate-linked moiety X motif 2) (Nudix motif 2)	NUDT2 APAH1	Homo sapiens (Human)	147	FUNCTION: Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (By similarity). Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (By similarity). {ECO:0000250|UniProtKB:P50584, ECO:0000250|UniProtKB:P56380}.		AMP biosynthetic process [GO:0006167]; apoptotic process [GO:0006915]; ATP biosynthetic process [GO:0006754]; cellular response to oxidative stress [GO:0034599]; nucleobase-containing compound metabolic process [GO:0006139]	mitochondrial matrix [GO:0005759]	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity [GO:0004081]; bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity [GO:0008803]; GTP binding [GO:0005525]	mitochondrial matrix [GO:0005759]; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity [GO:0004081]; bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity [GO:0008803]; GTP binding [GO:0005525]; AMP biosynthetic process [GO:0006167]; apoptotic process [GO:0006915]; ATP biosynthetic process [GO:0006754]; cellular response to oxidative stress [GO:0034599]; nucleobase-containing compound metabolic process [GO:0006139]	
P50591	reviewed	TNF10_HUMAN	Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)	TNFSF10 APO2L TRAIL	Homo sapiens (Human)	281	FUNCTION: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. {ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518}.	MISCELLANEOUS: [Isoform 2]: Induced upon HIV infection, antagonizes signaling via TRAIL receptor R2 (TNFRSF10B). {ECO:0000305}.	apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; immune response [GO:0006955]; male gonad development [GO:0008584]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; response to insulin [GO:0032868]; signal transduction [GO:0007165]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; TRAIL binding [GO:0045569]; tumor necrosis factor receptor binding [GO:0005164]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; TRAIL binding [GO:0045569]; tumor necrosis factor receptor binding [GO:0005164]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; immune response [GO:0006955]; male gonad development [GO:0008584]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; response to insulin [GO:0032868]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14609566}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:14609566}. Note=Exists both as membrane-bound and soluble form. {ECO:0000269|PubMed:14609566}.
P50607	reviewed	TUB_HUMAN	Tubby protein homolog	TUB	Homo sapiens (Human)	506	FUNCTION: Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269|PubMed:19837063}.		intraciliary transport [GO:0042073]; phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to cilium [GO:0061512]; protein localization to photoreceptor outer segment [GO:1903546]; receptor localization to non-motile cilium [GO:0097500]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to stimulus [GO:0050896]; retina development in camera-type eye [GO:0060041]; sensory perception of sound [GO:0007605]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	G protein-coupled receptor binding [GO:0001664]; intraciliary transport particle A binding [GO:0120160]; protein-containing complex binding [GO:0044877]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; G protein-coupled receptor binding [GO:0001664]; intraciliary transport particle A binding [GO:0120160]; protein-containing complex binding [GO:0044877]; intraciliary transport [GO:0042073]; phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to cilium [GO:0061512]; protein localization to photoreceptor outer segment [GO:1903546]; receptor localization to non-motile cilium [GO:0097500]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to stimulus [GO:0050896]; retina development in camera-type eye [GO:0060041]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). {ECO:0000250}.
P50613	reviewed	CDK7_HUMAN	Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)	CDK7 CAK CAK1 CDKN7 MO15 STK1	Homo sapiens (Human)	346	FUNCTION: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (PubMed:9852112). Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:9372954, ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}.		cell cycle [GO:0007049]; cell division [GO:0051301]; DNA repair [GO:0006281]; phosphorylation [GO:0016310]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	CAK-ERCC2 complex [GO:0070516]; cyclin-dependent protein kinase activating kinase holoenzyme complex [GO:0019907]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription factor TFIIK complex [GO:0070985]	ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]	CAK-ERCC2 complex [GO:0070516]; cyclin-dependent protein kinase activating kinase holoenzyme complex [GO:0019907]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription factor TFIIK complex [GO:0070985]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; cell cycle [GO:0007049]; cell division [GO:0051301]; DNA repair [GO:0006281]; phosphorylation [GO:0016310]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides (PubMed:19071173). {ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}.
P50616	reviewed	TOB1_HUMAN	Protein Tob1 (Transducer of erbB-2 1)	TOB1 TOB TROB1	Homo sapiens (Human)	345	FUNCTION: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). {ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:8632892}.		negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of translation [GO:0017148]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of gene expression [GO:0010468]; regulation of SMAD protein signal transduction [GO:0060390]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	receptor tyrosine kinase binding [GO:0030971]; SMAD binding [GO:0046332]; transcription corepressor activity [GO:0003714]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; receptor tyrosine kinase binding [GO:0030971]; SMAD binding [GO:0046332]; transcription corepressor activity [GO:0003714]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of translation [GO:0017148]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of gene expression [GO:0010468]; regulation of SMAD protein signal transduction [GO:0060390]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. {ECO:0000250}.
P50747	reviewed	BPL1_HUMAN	Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)]	HLCS	Homo sapiens (Human)	726	FUNCTION: Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}.		biotin metabolic process [GO:0006768]; post-translational protein modification [GO:0043687]; response to biotin [GO:0070781]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]	ATP binding [GO:0005524]; biotin binding [GO:0009374]; biotin-[acetyl-CoA-carboxylase] ligase activity [GO:0004077]; biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity [GO:0004078]; biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity [GO:0004079]; biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity [GO:0004080]; biotin-protein ligase activity [GO:0018271]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; ATP binding [GO:0005524]; biotin binding [GO:0009374]; biotin-[acetyl-CoA-carboxylase] ligase activity [GO:0004077]; biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity [GO:0004078]; biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity [GO:0004079]; biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity [GO:0004080]; biotin-protein ligase activity [GO:0018271]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; biotin metabolic process [GO:0006768]; post-translational protein modification [GO:0043687]; response to biotin [GO:0070781]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:7842009}. Mitochondrion {ECO:0000305|PubMed:7842009}.
P50748	reviewed	KNTC1_HUMAN	Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod)	KNTC1 KIAA0166	Homo sapiens (Human)	2209	FUNCTION: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131, ECO:0000305}.		cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore involved in kinetochore assembly [GO:1903394]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of exit from mitosis [GO:0007096]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore microtubule [GO:0005828]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RZZ complex [GO:1990423]; spindle pole [GO:0000922]	small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore microtubule [GO:0005828]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RZZ complex [GO:1990423]; spindle pole [GO:0000922]; small GTPase binding [GO:0031267]; cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore involved in kinetochore assembly [GO:1903394]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of exit from mitosis [GO:0007096]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at the spindle poles.
P50749	reviewed	RASF2_HUMAN	Ras association domain-containing protein 2	RASSF2 CENP-34 KIAA0168	Homo sapiens (Human)	326	FUNCTION: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. {ECO:0000269|PubMed:12732644, ECO:0000269|PubMed:16012945, ECO:0000269|PubMed:19525978}.		bone remodeling [GO:0046849]; cell cycle [GO:0007049]; epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade [GO:0038168]; homeostasis of number of cells [GO:0048872]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; ossification [GO:0001503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein kinase activity [GO:0045860]; protein stabilization [GO:0050821]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of osteoblast differentiation [GO:0045667]; regulation of osteoclast differentiation [GO:0045670]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	protein kinase activity [GO:0004672]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; protein kinase activity [GO:0004672]; bone remodeling [GO:0046849]; cell cycle [GO:0007049]; epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade [GO:0038168]; homeostasis of number of cells [GO:0048872]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; ossification [GO:0001503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein kinase activity [GO:0045860]; protein stabilization [GO:0050821]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of osteoblast differentiation [GO:0045667]; regulation of osteoclast differentiation [GO:0045670]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}. Note=Translocates to the cytoplasm in the presence of STK3/MST2 and STK4/MST1.
P50750	reviewed	CDK9_HUMAN	Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)	CDK9 CDC2L4 TAK	Homo sapiens (Human)	372	FUNCTION: Protein kinase involved in the regulation of transcription (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094, PubMed:29335245). Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094, PubMed:30134174). This complex is inactive when in the 7SK snRNP complex form (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094). Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE (PubMed:9857195, PubMed:10912001, PubMed:11112772, PubMed:12037670, PubMed:20081228, PubMed:20980437, PubMed:21127351). Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling) (PubMed:17956865, PubMed:18362169). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis (PubMed:10393184, PubMed:11112772). P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export (PubMed:15564463, PubMed:19575011, PubMed:19844166). Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing (PubMed:15564463, PubMed:19575011, PubMed:19844166). The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro (PubMed:21127351). Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage (PubMed:20493174). In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6 (PubMed:20493174). Promotes cardiac myocyte enlargement (PubMed:20081228). RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription (PubMed:21127351). AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect (PubMed:9857195, PubMed:10912001, PubMed:11112772). The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation (PubMed:12037670). Catalyzes phosphorylation of KAT5, promoting KAT5 recruitment to chromatin and histone acetyltransferase activity (PubMed:29335245). {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11145967, ECO:0000269|PubMed:11575923, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:11884399, ECO:0000269|PubMed:12037670, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15564463, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:17956865, ECO:0000269|PubMed:18362169, ECO:0000269|PubMed:19575011, ECO:0000269|PubMed:19844166, ECO:0000269|PubMed:20081228, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:20930849, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:28426094, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:9857195}.	MISCELLANEOUS: CDK9 inhibition contributes to the anticancer activity of most CDK inhibitors under clinical investigation (PubMed:18423896, PubMed:21779453). As a retroviruses target during the hijack of host transcription (e.g. HIV), CDK9 inhibitors might become specific antiretroviral agents (PubMed:18423896). May be a target for cardiac hypertrophy future treatments (PubMed:19757441, PubMed:18423896). May also be a target in anti-inflammatory therapy in innate immunity and systemic inflammation (PubMed:18728388). {ECO:0000305|PubMed:18423896, ECO:0000305|PubMed:18728388}.	cell population proliferation [GO:0008283]; cellular response to cytokine stimulus [GO:0071345]; DNA repair [GO:0006281]; negative regulation of protein localization to chromatin [GO:0120186]; nucleus localization [GO:0051647]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of protein localization to chromatin [GO:0120187]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of DNA repair [GO:0006282]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of muscle cell differentiation [GO:0051147]; replication fork processing [GO:0031297]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673]; transcription initiation at RNA polymerase II promoter [GO:0006367]	cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytoplasmic ribonucleoprotein granule [GO:0036464]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-TEFb complex [GO:0070691]; PML body [GO:0016605]; transcription elongation factor complex [GO:0008023]	7SK snRNA binding [GO:0097322]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; DNA binding [GO:0003677]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; transcription coactivator binding [GO:0001223]	cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytoplasmic ribonucleoprotein granule [GO:0036464]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-TEFb complex [GO:0070691]; PML body [GO:0016605]; transcription elongation factor complex [GO:0008023]; 7SK snRNA binding [GO:0097322]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; DNA binding [GO:0003677]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; transcription coactivator binding [GO:0001223]; cell population proliferation [GO:0008283]; cellular response to cytokine stimulus [GO:0071345]; DNA repair [GO:0006281]; negative regulation of protein localization to chromatin [GO:0120186]; nucleus localization [GO:0051647]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of protein localization to chromatin [GO:0120187]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of DNA repair [GO:0006282]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of muscle cell differentiation [GO:0051147]; replication fork processing [GO:0031297]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Nucleus, PML body. Note=Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated.
P50851	reviewed	LRBA_HUMAN	Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein)	LRBA BGL CDC4L LBA	Homo sapiens (Human)	2863	FUNCTION: Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}.		mitophagy [GO:0000423]; protein localization [GO:0008104]; protein localization to phagophore assembly site [GO:0034497]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	protein kinase binding [GO:0019901]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein kinase binding [GO:0019901]; mitophagy [GO:0000423]; protein localization [GO:0008104]; protein localization to phagophore assembly site [GO:0034497]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9ESE1}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ESE1}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:31263572}; Single-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q9ESE1}; Single-pass membrane protein {ECO:0000255}.
P50876	reviewed	R144A_HUMAN	E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4)	RNF144A KIAA0161 RNF144 UBCE7IP4	Homo sapiens (Human)	292	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC. {ECO:0000250, ECO:0000269|PubMed:24979766}.		positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24979766}; Single-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:24979766}.
P50895	reviewed	BCAM_HUMAN	Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239)	BCAM LU MSK19	Homo sapiens (Human)	628	FUNCTION: Laminin alpha-5 receptor. May mediate intracellular signaling. {ECO:0000269|PubMed:9616226}.		cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; signal transduction [GO:0007165]	collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	laminin binding [GO:0043236]; laminin receptor activity [GO:0005055]; transmembrane signaling receptor activity [GO:0004888]	collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; laminin binding [GO:0043236]; laminin receptor activity [GO:0005055]; transmembrane signaling receptor activity [GO:0004888]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P50897	reviewed	PPT1_HUMAN	Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1)	PPT1 CLN1 PPT	Homo sapiens (Human)	306	FUNCTION: Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (PubMed:8816748). {ECO:0000269|PubMed:8816748}.		adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; brain development [GO:0007420]; fatty-acyl-CoA biosynthetic process [GO:0046949]; grooming behavior [GO:0007625]; lipid catabolic process [GO:0016042]; lysosomal lumen acidification [GO:0007042]; membrane raft organization [GO:0031579]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neurotransmitter secretion [GO:0007269]; pinocytosis [GO:0006907]; positive regulation of pinocytosis [GO:0048549]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein catabolic process [GO:0030163]; protein depalmitoylation [GO:0002084]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; regulation of synapse structure or activity [GO:0050803]; response to stimulus [GO:0050896]; sphingolipid catabolic process [GO:0030149]; visual perception [GO:0007601]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021]	lysophosphatidic acid binding [GO:0035727]; palmitoyl-(protein) hydrolase activity [GO:0008474]; palmitoyl-CoA hydrolase activity [GO:0016290]; sulfatide binding [GO:0120146]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021]; lysophosphatidic acid binding [GO:0035727]; palmitoyl-(protein) hydrolase activity [GO:0008474]; palmitoyl-CoA hydrolase activity [GO:0016290]; sulfatide binding [GO:0120146]; adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; brain development [GO:0007420]; fatty-acyl-CoA biosynthetic process [GO:0046949]; grooming behavior [GO:0007625]; lipid catabolic process [GO:0016042]; lysosomal lumen acidification [GO:0007042]; membrane raft organization [GO:0031579]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neurotransmitter secretion [GO:0007269]; pinocytosis [GO:0006907]; positive regulation of pinocytosis [GO:0048549]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein catabolic process [GO:0030163]; protein depalmitoylation [GO:0002084]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; regulation of synapse structure or activity [GO:0050803]; response to stimulus [GO:0050896]; sphingolipid catabolic process [GO:0030149]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:19941651}. Secreted {ECO:0000250|UniProtKB:P45478}.
P50914	reviewed	RL14_HUMAN	Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (CAG-ISL 7)	RPL14	Homo sapiens (Human)	215	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; postsynaptic density [GO:0014069]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P50990	reviewed	TCPQ_HUMAN	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15)	CCT8 C21orf112 CCTQ KIAA0002	Homo sapiens (Human)	548	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.		binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intermediate filament cytoskeleton [GO:0045111]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774]; zona pellucida receptor complex [GO:0002199]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]	azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intermediate filament cytoskeleton [GO:0045111]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774]; zona pellucida receptor complex [GO:0002199]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]; binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20080638}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20080638}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P42932}.
P50991	reviewed	TCPD_HUMAN	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Stimulator of TAR RNA-binding)	CCT4 CCTD SRB	Homo sapiens (Human)	539	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.		binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666]	cell body [GO:0044297]; cell projection [GO:0042995]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; zona pellucida receptor complex [GO:0002199]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]	cell body [GO:0044297]; cell projection [GO:0042995]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; zona pellucida receptor complex [GO:0002199]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:20080638}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20080638}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P80315}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.
P50993	reviewed	AT1A2_HUMAN	Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2)	ATP1A2 KIAA0778	Homo sapiens (Human)	1020	FUNCTION: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}.		adult locomotory behavior [GO:0008344]; amygdala development [GO:0021764]; ATP metabolic process [GO:0046034]; behavioral fear response [GO:0001662]; cardiac muscle contraction [GO:0060048]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to mechanical stimulus [GO:0071260]; cellular response to steroid hormone stimulus [GO:0071383]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; locomotion [GO:0040011]; locomotory exploration behavior [GO:0035641]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane repolarization [GO:0086009]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of calcium ion transmembrane transport [GO:1903170]; negative regulation of calcium:sodium antiporter activity [GO:1903280]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of heart contraction [GO:0045822]; negative regulation of striated muscle contraction [GO:0045988]; neurotransmitter uptake [GO:0001504]; olfactory cortex development [GO:0021989]; positive regulation of heart contraction [GO:0045823]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; proton transmembrane transport [GO:1902600]; regulation of blood pressure [GO:0008217]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946]; regulation of muscle contraction [GO:0006937]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of smooth muscle contraction [GO:0006940]; regulation of striated muscle contraction [GO:0006942]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of the force of heart contraction [GO:0002026]; regulation of vasoconstriction [GO:0019229]; relaxation of cardiac muscle [GO:0055119]; response to auditory stimulus [GO:0010996]; response to glycoside [GO:1903416]; response to nicotine [GO:0035094]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; transport across blood-brain barrier [GO:0150104]; visual learning [GO:0008542]	caveola [GO:0005901]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; endosome [GO:0005768]; extracellular vesicle [GO:1903561]; intercalated disc [GO:0014704]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; T-tubule [GO:0030315]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; phosphatase activity [GO:0016791]; potassium ion binding [GO:0030955]; protein heterodimerization activity [GO:0046982]; protein-folding chaperone binding [GO:0051087]; sodium ion binding [GO:0031402]; steroid binding [GO:0005496]; steroid hormone binding [GO:1990239]	caveola [GO:0005901]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; endosome [GO:0005768]; extracellular vesicle [GO:1903561]; intercalated disc [GO:0014704]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; T-tubule [GO:0030315]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; phosphatase activity [GO:0016791]; potassium ion binding [GO:0030955]; protein heterodimerization activity [GO:0046982]; protein-folding chaperone binding [GO:0051087]; sodium ion binding [GO:0031402]; steroid binding [GO:0005496]; steroid hormone binding [GO:1990239]; adult locomotory behavior [GO:0008344]; amygdala development [GO:0021764]; ATP metabolic process [GO:0046034]; behavioral fear response [GO:0001662]; cardiac muscle contraction [GO:0060048]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to mechanical stimulus [GO:0071260]; cellular response to steroid hormone stimulus [GO:0071383]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; locomotion [GO:0040011]; locomotory exploration behavior [GO:0035641]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane repolarization [GO:0086009]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of calcium ion transmembrane transport [GO:1903170]; negative regulation of calcium:sodium antiporter activity [GO:1903280]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of heart contraction [GO:0045822]; negative regulation of striated muscle contraction [GO:0045988]; neurotransmitter uptake [GO:0001504]; olfactory cortex development [GO:0021989]; positive regulation of heart contraction [GO:0045823]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; proton transmembrane transport [GO:1902600]; regulation of blood pressure [GO:0008217]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946]; regulation of muscle contraction [GO:0006937]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of smooth muscle contraction [GO:0006940]; regulation of striated muscle contraction [GO:0006942]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of the force of heart contraction [GO:0002026]; regulation of vasoconstriction [GO:0019229]; relaxation of cardiac muscle [GO:0055119]; response to auditory stimulus [GO:0010996]; response to glycoside [GO:1903416]; response to nicotine [GO:0035094]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; transport across blood-brain barrier [GO:0150104]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000269|PubMed:7711835}. Cell membrane {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000269|PubMed:7711835}.
P50995	reviewed	ANX11_HUMAN	Annexin A11 (56 kDa autoantigen) (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50)	ANXA11 ANX11	Homo sapiens (Human)	505	FUNCTION: Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. {ECO:0000250, ECO:0000269|PubMed:15197175}.		cytokinetic process [GO:0032506]; phagocytosis [GO:0006909]; response to calcium ion [GO:0051592]	azurophil granule [GO:0042582]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; specific granule [GO:0042581]; spindle [GO:0005819]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; MHC class II protein complex binding [GO:0023026]; phosphatidylethanolamine binding [GO:0008429]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548]	azurophil granule [GO:0042582]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; specific granule [GO:0042581]; spindle [GO:0005819]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; MHC class II protein complex binding [GO:0023026]; phosphatidylethanolamine binding [GO:0008429]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548]; cytokinetic process [GO:0032506]; phagocytosis [GO:0006909]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28469040}. Melanosome. Nucleus envelope. Nucleus, nucleoplasm {ECO:0000269|PubMed:28469040}. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. {ECO:0000250}.
P51003	reviewed	PAPOA_HUMAN	Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha)	PAPOLA PAP	Homo sapiens (Human)	745	FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}.		cytoplasmic polyadenylation [GO:0180011]; mRNA 3'-end processing [GO:0031124]; mRNA polyadenylation [GO:0006378]; regulation of mRNA 3'-end processing [GO:0031440]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; cytoplasmic polyadenylation [GO:0180011]; mRNA 3'-end processing [GO:0031124]; mRNA polyadenylation [GO:0006378]; regulation of mRNA 3'-end processing [GO:0031440]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The 90 kDa form is nuclear while the 100 kDa and the 106 kDa forms are both nuclear and cytoplasmic.
P51114	reviewed	FXR1_HUMAN	RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p)	FXR1	Homo sapiens (Human)	621	FUNCTION: mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353}.		apoptotic process [GO:0006915]; dentate gyrus development [GO:0021542]; mRNA destabilization [GO:0061157]; muscle organ development [GO:0007517]; negative regulation of inflammatory response [GO:0050728]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of translation [GO:0017148]; negative regulation of tumor necrosis factor production [GO:0032720]; non-membrane-bounded organelle assembly [GO:0140694]; nuclear pore complex assembly [GO:0051292]; nuclear pore localization [GO:0051664]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of filopodium assembly [GO:0051489]; regulation of mRNA stability [GO:0043488]; regulation of neurogenesis [GO:0050767]; regulation of synaptic transmission, glutamatergic [GO:0051966]; skeletal muscle organ development [GO:0060538]; spermatid development [GO:0007286]	axon [GO:0030424]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendritic filopodium [GO:1902737]; dendritic spine [GO:0043197]; dendritic spine neck [GO:0044326]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]	molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA strand annealing activity [GO:0033592]; translation regulator activity [GO:0045182]	axon [GO:0030424]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendritic filopodium [GO:1902737]; dendritic spine [GO:0043197]; dendritic spine neck [GO:0044326]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA strand annealing activity [GO:0033592]; translation regulator activity [GO:0045182]; apoptotic process [GO:0006915]; dentate gyrus development [GO:0021542]; mRNA destabilization [GO:0061157]; muscle organ development [GO:0007517]; negative regulation of inflammatory response [GO:0050728]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of translation [GO:0017148]; negative regulation of tumor necrosis factor production [GO:0032720]; non-membrane-bounded organelle assembly [GO:0140694]; nuclear pore complex assembly [GO:0051292]; nuclear pore localization [GO:0051664]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of filopodium assembly [GO:0051489]; regulation of mRNA stability [GO:0043488]; regulation of neurogenesis [GO:0050767]; regulation of synaptic transmission, glutamatergic [GO:0051966]; skeletal muscle organ development [GO:0060538]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:32706158}. Cytoplasm, Stress granule {ECO:0000269|PubMed:20417602}. Cytoplasm {ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:7781595, ECO:0000269|PubMed:9259278}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q61584}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q61584}. Cell projection, axon {ECO:0000250|UniProtKB:Q61584}. Nucleus envelope {ECO:0000269|PubMed:32706158}. Postsynapse {ECO:0000250|UniProtKB:Q61584}. Note=Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments (By similarity). Localizes to stress granules following phosphorylation at Ser-420 by PAK1 (PubMed:20417602). Adjacent to Z-lines in muscles (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:20417602}.
P51116	reviewed	FXR2_HUMAN	RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2)	FXR2 FMR1L2	Homo sapiens (Human)	673	FUNCTION: mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}.		dentate gyrus development [GO:0021542]; mRNA destabilization [GO:0061157]; negative regulation of translation [GO:0017148]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of filopodium assembly [GO:0051489]; regulation of mRNA stability [GO:0043488]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendritic filopodium [GO:1902737]; dendritic spine [GO:0043197]; dendritic spine neck [GO:0044326]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; polysome [GO:0005844]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]	identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendritic filopodium [GO:1902737]; dendritic spine [GO:0043197]; dendritic spine neck [GO:0044326]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; polysome [GO:0005844]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182]; dentate gyrus development [GO:0021542]; mRNA destabilization [GO:0061157]; negative regulation of translation [GO:0017148]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of filopodium assembly [GO:0051489]; regulation of mRNA stability [GO:0043488]	SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q61584}. Cytoplasm {ECO:0000269|PubMed:9259278}. Postsynapse {ECO:0000250|UniProtKB:Q9WVR4}. Note=Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments (By similarity). Localization to the post-synaptic region is dependent on FMR1 (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}.
P51124	reviewed	GRAM_HUMAN	Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease)	GZMM MET1	Homo sapiens (Human)	257	FUNCTION: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. {ECO:0000269|PubMed:18523284, ECO:0000269|PubMed:20406824}.		apoptotic process [GO:0006915]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; proteolysis [GO:0006508]; T cell mediated cytotoxicity [GO:0001913]	extracellular region [GO:0005576]; membrane [GO:0016020]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular region [GO:0005576]; membrane [GO:0016020]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; apoptotic process [GO:0006915]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; proteolysis [GO:0006508]; T cell mediated cytotoxicity [GO:0001913]	SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes.
P51148	reviewed	RAB5C_HUMAN	Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)	RAB5C RABL	Homo sapiens (Human)	216	FUNCTION: Protein transport. Probably involved in vesicular traffic. {ECO:0000250|UniProtKB:P20339}.		endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; plasma membrane to endosome transport [GO:0048227]	azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; plasma membrane [GO:0005886]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; plasma membrane to endosome transport [GO:0048227]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20339}; Lipid-anchor {ECO:0000250|UniProtKB:P20339}; Cytoplasmic side {ECO:0000250|UniProtKB:P20339}. Early endosome membrane {ECO:0000250|UniProtKB:P20339}; Lipid-anchor {ECO:0000250|UniProtKB:P20339}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.
P51149	reviewed	RAB7A_HUMAN	Ras-related protein Rab-7a (EC 3.6.5.2)	RAB7A RAB7	Homo sapiens (Human)	207	FUNCTION: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Required for vesicular trafficking and cell surface expression of ACE2 (PubMed:33147445). May play a role in PRPH neuronal intermediate filament assembly (By similarity). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:33147445}.		autophagosome assembly [GO:0000045]; bone resorption [GO:0045453]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endosome to plasma membrane protein transport [GO:0099638]; epidermal growth factor catabolic process [GO:0007174]; establishment of vesicle localization [GO:0051650]; intracellular transport [GO:0046907]; lipid catabolic process [GO:0016042]; lipophagy [GO:0061724]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of intralumenal vesicle formation [GO:1905366]; phagosome acidification [GO:0090383]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of viral process [GO:0048524]; protein targeting to lysosome [GO:0006622]; protein to membrane docking [GO:0022615]; protein transport [GO:0015031]; response to bacterium [GO:0009617]; retrograde transport, endosome to Golgi [GO:0042147]; viral release from host cell [GO:0019076]	alveolar lamellar body [GO:0097208]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site membrane [GO:0034045]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; retromer complex binding [GO:1905394]; small GTPase binding [GO:0031267]	alveolar lamellar body [GO:0097208]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site membrane [GO:0034045]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; retromer complex binding [GO:1905394]; small GTPase binding [GO:0031267]; autophagosome assembly [GO:0000045]; bone resorption [GO:0045453]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endosome to plasma membrane protein transport [GO:0099638]; epidermal growth factor catabolic process [GO:0007174]; establishment of vesicle localization [GO:0051650]; intracellular transport [GO:0046907]; lipid catabolic process [GO:0016042]; lipophagy [GO:0061724]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of intralumenal vesicle formation [GO:1905366]; phagosome acidification [GO:0090383]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of viral process [GO:0048524]; protein targeting to lysosome [GO:0006622]; protein to membrane docking [GO:0022615]; protein transport [GO:0015031]; response to bacterium [GO:0009617]; retrograde transport, endosome to Golgi [GO:0042147]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:21255211}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:28325809}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:20028791}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:20028791}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lipid droplet {ECO:0000250|UniProtKB:P51150}. Endosome membrane {ECO:0000269|PubMed:22431521}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P51150}. Mitochondrion membrane {ECO:0000305|PubMed:34432599}; Peripheral membrane protein {ECO:0000305}. Note=Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (PubMed:21255211). Lipid droplet localization is increased upon ADRB2 stimulation (By similarity). Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner (PubMed:34432599). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:34432599}.
P51151	reviewed	RAB9A_HUMAN	Ras-related protein Rab-9A	RAB9A RAB9	Homo sapiens (Human)	201	FUNCTION: Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. {ECO:0000250|UniProtKB:P24408, ECO:0000250|UniProtKB:Q9R0M6}.		negative regulation by host of symbiont catalytic activity [GO:0052403]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; negative regulation by host of symbiont catalytic activity [GO:0052403]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}. Golgi apparatus membrane {ECO:0000305}. Late endosome {ECO:0000269|PubMed:16176980}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9R0M6}. Melanosome {ECO:0000250|UniProtKB:Q9R0M6}. Note=Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:21255211}.
P51153	reviewed	RAB13_HUMAN	Ras-related protein Rab-13 (Cell growth-inhibiting gene 4 protein)	RAB13 GIG4	Homo sapiens (Human)	203	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367, ECO:0000269|PubMed:20008558}.		bicellular tight junction assembly [GO:0070830]; cellular response to insulin stimulus [GO:0032869]; cortical actin cytoskeleton organization [GO:0030866]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; endothelial cell chemotaxis [GO:0035767]; establishment of Sertoli cell barrier [GO:0097368]; Golgi vesicle fusion to target membrane [GO:0048210]; neuron projection development [GO:0031175]; protein kinase A signaling [GO:0010737]; protein localization to cell leading edge [GO:1902463]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; trans-Golgi network to recycling endosome transport [GO:0044795]; vesicle docking involved in exocytosis [GO:0006904]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; insulin-responsive compartment [GO:0032593]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; insulin-responsive compartment [GO:0032593]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; bicellular tight junction assembly [GO:0070830]; cellular response to insulin stimulus [GO:0032869]; cortical actin cytoskeleton organization [GO:0030866]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; endothelial cell chemotaxis [GO:0035767]; establishment of Sertoli cell barrier [GO:0097368]; Golgi vesicle fusion to target membrane [GO:0048210]; neuron projection development [GO:0031175]; protein kinase A signaling [GO:0010737]; protein localization to cell leading edge [GO:1902463]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; trans-Golgi network to recycling endosome transport [GO:0044795]; vesicle docking involved in exocytosis [GO:0006904]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15528189}; Lipid-anchor {ECO:0000305|PubMed:8375503}; Cytoplasmic side {ECO:0000305|PubMed:8375503}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:8294494}; Lipid-anchor {ECO:0000305|PubMed:8375503}; Cytoplasmic side {ECO:0000305|PubMed:8375503}. Cell junction, tight junction {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:8294494}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18779367}. Recycling endosome membrane {ECO:0000269|PubMed:18779367}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9DD03}. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (PubMed:8294494). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity). {ECO:0000250|UniProtKB:Q9DD03, ECO:0000269|PubMed:8294494}.
P51157	reviewed	RAB28_HUMAN	Ras-related protein Rab-28	RAB28	Homo sapiens (Human)	221			intracellular protein transport [GO:0006886]	ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body. Note=Expressed in the basal body and ciliary rootlet of the photoreceptors. {ECO:0000250}.
P51159	reviewed	RB27A_HUMAN	Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram)	RAB27A RAB27	Homo sapiens (Human)	221	FUNCTION: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. {ECO:0000269|PubMed:18812475, ECO:0000269|PubMed:30771381}.		antigen processing and presentation [GO:0019882]; blood coagulation [GO:0007596]; complement-dependent cytotoxicity [GO:0097278]; cytotoxic T cell degranulation [GO:0043316]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanocyte differentiation [GO:0030318]; melanosome localization [GO:0032400]; melanosome transport [GO:0032402]; multivesicular body organization [GO:0036257]; multivesicular body sorting pathway [GO:0071985]; natural killer cell degranulation [GO:0043320]; positive regulation of constitutive secretory pathway [GO:1903435]; positive regulation of exocytosis [GO:0045921]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of regulated secretory pathway [GO:1903307]; synaptic vesicle transport [GO:0048489]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; dendrite [GO:0030425]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; multivesicular body membrane [GO:0032585]; photoreceptor outer segment [GO:0001750]; secretory granule [GO:0030141]; specific granule lumen [GO:0035580]; Weibel-Palade body [GO:0033093]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; dendrite [GO:0030425]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; multivesicular body membrane [GO:0032585]; photoreceptor outer segment [GO:0001750]; secretory granule [GO:0030141]; specific granule lumen [GO:0035580]; Weibel-Palade body [GO:0033093]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904]; antigen processing and presentation [GO:0019882]; blood coagulation [GO:0007596]; complement-dependent cytotoxicity [GO:0097278]; cytotoxic T cell degranulation [GO:0043316]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanocyte differentiation [GO:0030318]; melanosome localization [GO:0032400]; melanosome transport [GO:0032402]; multivesicular body organization [GO:0036257]; multivesicular body sorting pathway [GO:0071985]; natural killer cell degranulation [GO:0043320]; positive regulation of constitutive secretory pathway [GO:1903435]; positive regulation of exocytosis [GO:0045921]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of regulated secretory pathway [GO:1903307]; synaptic vesicle transport [GO:0048489]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Late endosome {ECO:0000269|PubMed:15548590, ECO:0000269|PubMed:30771381}. Lysosome {ECO:0000269|PubMed:15548590}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). Localizes to endosomal exocytic vesicles (PubMed:17237785). {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:17237785}.
P51160	reviewed	PDE6C_HUMAN	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC 3.1.4.35) (cGMP phosphodiesterase 6C)	PDE6C PDEA2	Homo sapiens (Human)	858	FUNCTION: As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. {ECO:0000269|PubMed:21127010, ECO:0000269|PubMed:28583373}.		phototransduction, visible light [GO:0007603]; retinal cone cell development [GO:0046549]; signal transduction [GO:0007165]; visual perception [GO:0007601]	plasma membrane [GO:0005886]	3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP binding [GO:0030553]; metal ion binding [GO:0046872]	plasma membrane [GO:0005886]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP binding [GO:0030553]; metal ion binding [GO:0046872]; phototransduction, visible light [GO:0007603]; retinal cone cell development [GO:0046549]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P51161	reviewed	FABP6_HUMAN	Gastrotropin (GT) (Fatty acid-binding protein 6) (Ileal lipid-binding protein) (ILBP) (Intestinal 15 kDa protein) (I-15P) (Intestinal bile acid-binding protein) (I-BABP)	FABP6 ILBP ILLBP	Homo sapiens (Human)	128	FUNCTION: Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity). {ECO:0000250|UniProtKB:P10289, ECO:0000250|UniProtKB:P51162, ECO:0000269|PubMed:12486725, ECO:0000269|PubMed:7588781}.; FUNCTION: [Isoform 2]: Essential for the survival of colon cancer cells to bile acid-induced apoptosis. {ECO:0000269|PubMed:17909007}.		fatty acid transport [GO:0015908]; lipid metabolic process [GO:0006629]; negative regulation of cell population proliferation [GO:0008285]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	fatty acid binding [GO:0005504]; lipid binding [GO:0008289]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; fatty acid binding [GO:0005504]; lipid binding [GO:0008289]; fatty acid transport [GO:0015908]; lipid metabolic process [GO:0006629]; negative regulation of cell population proliferation [GO:0008285]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:P80020}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P50119}; Cytoplasmic side {ECO:0000250|UniProtKB:P50119}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17909007}. Note=Localized close to nucleus on the apical side of both normal and neoplastic cells. {ECO:0000269|PubMed:17909007}.
P51164	reviewed	ATP4B_HUMAN	Potassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain)	ATP4B	Homo sapiens (Human)	291	FUNCTION: The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity). {ECO:0000250|UniProtKB:P18597, ECO:0000250|UniProtKB:P19156}.		cell adhesion [GO:0007155]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; pH reduction [GO:0045851]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; response to lipopolysaccharide [GO:0032496]; response to organonitrogen compound [GO:0010243]; sodium ion export across plasma membrane [GO:0036376]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; potassium:proton exchanging ATPase complex [GO:0005889]; sodium:potassium-exchanging ATPase complex [GO:0005890]	ATPase activator activity [GO:0001671]; heterocyclic compound binding [GO:1901363]; P-type potassium:proton transporter activity [GO:0008900]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; potassium:proton exchanging ATPase complex [GO:0005889]; sodium:potassium-exchanging ATPase complex [GO:0005890]; ATPase activator activity [GO:0001671]; heterocyclic compound binding [GO:1901363]; P-type potassium:proton transporter activity [GO:0008900]; cell adhesion [GO:0007155]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; pH reduction [GO:0045851]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; response to lipopolysaccharide [GO:0032496]; response to organonitrogen compound [GO:0010243]; sodium ion export across plasma membrane [GO:0036376]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P20648}; Single-pass type II membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P18597}; Single-pass type II membrane protein {ECO:0000255}. Note=Localized in the apical canalicular membrane of parietal cells. {ECO:0000250|UniProtKB:P20648}.
P51168	reviewed	SCNNB_HUMAN	Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (ENaCB) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)	SCNN1B	Homo sapiens (Human)	640	FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO:0000269|PubMed:7762608, ECO:0000303|PubMed:7490094}.		aldosterone metabolic process [GO:0032341]; artery smooth muscle contraction [GO:0014824]; cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; epithelial fluid transport [GO:0042045]; erythrocyte homeostasis [GO:0034101]; gene expression [GO:0010467]; intracellular sodium ion homeostasis [GO:0006883]; leukocyte activation involved in inflammatory response [GO:0002269]; mucus secretion [GO:0070254]; multicellular organism growth [GO:0035264]; multicellular organismal-level water homeostasis [GO:0050891]; neutrophil activation involved in immune response [GO:0002283]; neutrophil-mediated killing of bacterium [GO:0070944]; potassium ion homeostasis [GO:0055075]; regulation of blood pressure [GO:0008217]; renal system process [GO:0003014]; response to food [GO:0032094]; response to xenobiotic stimulus [GO:0009410]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]	ligand-gated sodium channel activity [GO:0015280]; WW domain binding [GO:0050699]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]; ligand-gated sodium channel activity [GO:0015280]; WW domain binding [GO:0050699]; aldosterone metabolic process [GO:0032341]; artery smooth muscle contraction [GO:0014824]; cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; epithelial fluid transport [GO:0042045]; erythrocyte homeostasis [GO:0034101]; gene expression [GO:0010467]; intracellular sodium ion homeostasis [GO:0006883]; leukocyte activation involved in inflammatory response [GO:0002269]; mucus secretion [GO:0070254]; multicellular organism growth [GO:0035264]; multicellular organismal-level water homeostasis [GO:0050891]; neutrophil activation involved in immune response [GO:0002283]; neutrophil-mediated killing of bacterium [GO:0070944]; potassium ion homeostasis [GO:0055075]; regulation of blood pressure [GO:0008217]; renal system process [GO:0003014]; response to food [GO:0032094]; response to xenobiotic stimulus [GO:0009410]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000305|PubMed:7490094}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P37090}. Note=Apical membrane of epithelial cells. {ECO:0000305|PubMed:7490094}.
P51170	reviewed	SCNNG_HUMAN	Amiloride-sensitive sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (ENaCG) (Gamma-ENaC) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG)	SCNN1G	Homo sapiens (Human)	649	FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO:0000269|PubMed:24124190, ECO:0000269|PubMed:7550319, ECO:0000303|PubMed:7490094}.		cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; intracellular sodium ion homeostasis [GO:0006883]; multicellular organismal-level water homeostasis [GO:0050891]; regulation of blood pressure [GO:0008217]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]	ligand-gated sodium channel activity [GO:0015280]; monoatomic ion channel activity [GO:0005216]; sodium channel activity [GO:0005272]; WW domain binding [GO:0050699]	apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]; ligand-gated sodium channel activity [GO:0015280]; monoatomic ion channel activity [GO:0005216]; sodium channel activity [GO:0005272]; WW domain binding [GO:0050699]; cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; intracellular sodium ion homeostasis [GO:0006883]; multicellular organismal-level water homeostasis [GO:0050891]; regulation of blood pressure [GO:0008217]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:24124190, ECO:0000303|PubMed:7490094}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}. Note=Apical membrane of epithelial cells. {ECO:0000303|PubMed:7490094}.
P51172	reviewed	SCNND_HUMAN	Amiloride-sensitive sodium channel subunit delta (Delta-NaCH) (Epithelial Na(+) channel subunit delta) (Delta-ENaC) (ENaCD) (Nonvoltage-gated sodium channel 1 subunit delta) (SCNED)	SCNN1D DNACH	Homo sapiens (Human)	802	FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO:0000269|PubMed:16423824, ECO:0000269|PubMed:7499195}.	MISCELLANEOUS: [Isoform 2]: Channels including isoform 2 exhibit greater conductance than those containing isoform 1. {ECO:0000305}.	cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; intracellular sodium ion homeostasis [GO:0006883]; regulation of blood pressure [GO:0008217]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	actin cytoskeleton [GO:0015629]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]	ligand-gated sodium channel activity [GO:0015280]	actin cytoskeleton [GO:0015629]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]; ligand-gated sodium channel activity [GO:0015280]; cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; intracellular sodium ion homeostasis [GO:0006883]; regulation of blood pressure [GO:0008217]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19520916}; Multi-pass membrane protein {ECO:0000269|PubMed:19520916}.
P51178	reviewed	PLCD1_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)	PLCD1	Homo sapiens (Human)	756	FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:9188725). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (PubMed:7890667, PubMed:9188725). {ECO:0000250|UniProtKB:Q8R3B1, ECO:0000269|PubMed:7890667, ECO:0000269|PubMed:9188725}.		lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid metabolic process [GO:0006644]; release of sequestered calcium ion into cytosol [GO:0051209]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; GTPase activating protein binding [GO:0032794]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; GTPase activating protein binding [GO:0032794]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid metabolic process [GO:0006644]; release of sequestered calcium ion into cytosol [GO:0051209]	
P51397	reviewed	DAP1_HUMAN	Death-associated protein 1 (DAP-1)	DAP DAP1	Homo sapiens (Human)	102	FUNCTION: Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity). Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy (PubMed:20537536). Involved in mediating interferon-gamma-induced cell death (PubMed:7828849). {ECO:0000250|UniProtKB:Q9I9N1, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:7828849}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; regulation of translation [GO:0006417]		death domain binding [GO:0070513]	death domain binding [GO:0070513]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; regulation of translation [GO:0006417]	
P51398	reviewed	RT29_HUMAN	Small ribosomal subunit protein mS29 (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein)	DAP3 MRPS29	Homo sapiens (Human)	398	FUNCTION: Involved in mediating interferon-gamma-induced cell death.		apoptotic signaling pathway [GO:0097190]; mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GTP binding [GO:0005525]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; GTP binding [GO:0005525]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; apoptotic signaling pathway [GO:0097190]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11162496, ECO:0000269|PubMed:20563667}.
P51449	reviewed	RORG_HUMAN	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma)	RORC NR1F3 RORG RZRG	Homo sapiens (Human)	518	FUNCTION: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC1 and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376). {ECO:0000250|UniProtKB:P51450, ECO:0000269|PubMed:19381306, ECO:0000269|PubMed:19965867, ECO:0000269|PubMed:20203100, ECO:0000269|PubMed:22789990, ECO:0000269|PubMed:26160376}.; FUNCTION: [Isoform 2]: Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches. Required for the generation of LTi (lymphoid tissue inducer) cells. Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus. {ECO:0000269|PubMed:21499262}.		adipose tissue development [GO:0060612]; cellular response to sterol [GO:0036315]; circadian regulation of gene expression [GO:0032922]; lymph node development [GO:0048535]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Peyer's patch development [GO:0048541]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of fat cell differentiation [GO:0045598]; regulation of glucose metabolic process [GO:0010906]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 17 cell differentiation [GO:0072539]; T-helper cell differentiation [GO:0042093]; xenobiotic metabolic process [GO:0006805]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; ligand-activated transcription factor activity [GO:0098531]; nuclear receptor activity [GO:0004879]; oxysterol binding [GO:0008142]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; ligand-activated transcription factor activity [GO:0098531]; nuclear receptor activity [GO:0004879]; oxysterol binding [GO:0008142]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; adipose tissue development [GO:0060612]; cellular response to sterol [GO:0036315]; circadian regulation of gene expression [GO:0032922]; lymph node development [GO:0048535]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Peyer's patch development [GO:0048541]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of fat cell differentiation [GO:0045598]; regulation of glucose metabolic process [GO:0010906]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 17 cell differentiation [GO:0072539]; T-helper cell differentiation [GO:0042093]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26160376}.
P51451	reviewed	BLK_HUMAN	Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)	BLK	Homo sapiens (Human)	505	FUNCTION: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214). {ECO:0000250|UniProtKB:P16277, ECO:0000269|PubMed:19667185, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:8756631}.		B cell receptor signaling pathway [GO:0050853]; cell differentiation [GO:0030154]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein binding [GO:0032092]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]	cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; B cell receptor signaling pathway [GO:0050853]; cell differentiation [GO:0030154]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein binding [GO:0032092]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). {ECO:0000250}.
P51452	reviewed	DUS3_HUMAN	Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR)	DUSP3 VHR	Homo sapiens (Human)	185	FUNCTION: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:11863439}.		cellular response to epidermal growth factor stimulus [GO:0071364]; dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of focal adhesion assembly [GO:0051893]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cytoskeletal protein binding [GO:0008092]; MAP kinase phosphatase activity [GO:0033549]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; receptor tyrosine kinase binding [GO:0030971]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cytoskeletal protein binding [GO:0008092]; MAP kinase phosphatase activity [GO:0033549]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; receptor tyrosine kinase binding [GO:0030971]; cellular response to epidermal growth factor stimulus [GO:0071364]; dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of focal adhesion assembly [GO:0051893]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10224087}.
P51460	reviewed	INSL3_HUMAN	Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain]	INSL3 RLF RLNL	Homo sapiens (Human)	131	FUNCTION: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cell-cell signaling [GO:0007267]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; oocyte maturation [GO:0001556]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of wound healing [GO:0090303]; spermatogenesis [GO:0007283]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]	G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; insulin receptor binding [GO:0005158]; protease binding [GO:0002020]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; insulin receptor binding [GO:0005158]; protease binding [GO:0002020]; signaling receptor binding [GO:0005102]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cell-cell signaling [GO:0007267]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; oocyte maturation [GO:0001556]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of wound healing [GO:0090303]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Secreted.
P51511	reviewed	MMP15_HUMAN	Matrix metalloproteinase-15 (MMP-15) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP-2)	MMP15	Homo sapiens (Human)	669	FUNCTION: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. {ECO:0000269|PubMed:9461298}.		collagen catabolic process [GO:0030574]; endodermal cell differentiation [GO:0035987]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; response to estradiol [GO:0032355]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; collagen catabolic process [GO:0030574]; endodermal cell differentiation [GO:0035987]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; response to estradiol [GO:0032355]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}.
P51512	reviewed	MMP16_HUMAN	Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)	MMP16 C8orf57 MMPX2	Homo sapiens (Human)	607	FUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. {ECO:0000269|PubMed:11278606}.		chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; protein processing [GO:0016485]; proteolysis [GO:0006508]; skeletal system development [GO:0001501]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; protein processing [GO:0016485]; proteolysis [GO:0006508]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Note=Localized at the cell surface of melanoma cells.; SUBCELLULAR LOCATION: [Isoform Short]: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized at the cell surface of melanoma cells.
P51513	reviewed	NOVA1_HUMAN	RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Onconeural ventral antigen 1) (Paraneoplastic Ri antigen) (Ventral neuron-specific protein 1)	NOVA1	Homo sapiens (Human)	507	FUNCTION: Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion. It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons (PubMed:10811881). Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion. Binding to 5'-YCAY-3' clusters results in a local and asymmetric action to regulate spliceosome assembly and alternative splicing in neurons. Binding to an exonic 5'-YCAY-3' cluster changed the protein complexes assembled on pre-mRNA, blocking U1 snRNP (small nuclear ribonucleoprotein) binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhanced spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Autoregulates its own expression by acting as a splicing repressor. Acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer. Acts to regulate a novel glycine receptor alpha-2 chain splice variant (alpha-2N) in developing spinal cord (By similarity). {ECO:0000250|UniProtKB:Q9JKN6, ECO:0000269|PubMed:10811881}.	MISCELLANEOUS: Target antigen in a human paraneoplastic motor disorder, paraneoplastic opsoclonus-myoclonus ataxia (POMA). POMA antibodies block NOVAl RNA binding. {ECO:0000305|PubMed:8558240}.	mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cold-induced thermogenesis [GO:0120163]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cold-induced thermogenesis [GO:0120163]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JKN6}.
P51530	reviewed	DNA2_HUMAN	DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)]	DNA2 DNA2L KIAA0083	Homo sapiens (Human)	1060	FUNCTION: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function. {ECO:0000269|PubMed:16595799, ECO:0000269|PubMed:16595800, ECO:0000269|PubMed:18995831, ECO:0000269|PubMed:19487465, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:21572043, ECO:0000269|PubMed:22570407, ECO:0000269|PubMed:22570476}.		base-excision repair [GO:0006284]; DNA double-strand break processing [GO:0000729]; DNA replication [GO:0006260]; DNA replication checkpoint signaling [GO:0000076]; DNA replication, Okazaki fragment processing [GO:0033567]; DNA replication, removal of RNA primer [GO:0043137]; G-quadruplex DNA unwinding [GO:0044806]; mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of DNA replication [GO:0045740]; replication fork reversal [GO:0071932]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; 5'-flap endonuclease activity [GO:0017108]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; RNA binding [GO:0003723]; single-stranded DNA helicase activity [GO:0017116]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; 5'-flap endonuclease activity [GO:0017108]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; RNA binding [GO:0003723]; single-stranded DNA helicase activity [GO:0017116]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]; base-excision repair [GO:0006284]; DNA double-strand break processing [GO:0000729]; DNA replication [GO:0006260]; DNA replication checkpoint signaling [GO:0000076]; DNA replication, Okazaki fragment processing [GO:0033567]; DNA replication, removal of RNA primer [GO:0043137]; G-quadruplex DNA unwinding [GO:0044806]; mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of DNA replication [GO:0045740]; replication fork reversal [GO:0071932]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]	SUBCELLULAR LOCATION: Nucleus. Mitochondrion. Note=Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465). {ECO:0000269|PubMed:18995831, ECO:0000269|PubMed:19487465}.
P51531	reviewed	SMCA2_HUMAN	Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2)	SMARCA2 BAF190B BRM SNF2A SNF2L2	Homo sapiens (Human)	1590	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.		chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]	ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; hydrolase activity [GO:0016787]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; hydrolase activity [GO:0016787]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11259672, ECO:0000269|PubMed:25593309}. Note=Localizes to sites of DNA damage. {ECO:0000269|PubMed:25593309}.
P51532	reviewed	SMCA4_HUMAN	Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)	SMARCA4 BAF190A BRG1 SNF2B SNF2L4	Homo sapiens (Human)	1647	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.		chromatin remodeling [GO:0006338]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural retina development [GO:0003407]; nucleosome disassembly [GO:0006337]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase I preinitiation complex assembly [GO:0001188]; transcription initiation-coupled chromatin remodeling [GO:0045815]	bBAF complex [GO:0140092]; chromatin [GO:0000785]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; GBAF complex [GO:0140288]; kinetochore [GO:0000776]; membrane [GO:0016020]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; lysine-acetylated histone binding [GO:0070577]; nuclear androgen receptor binding [GO:0050681]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]	bBAF complex [GO:0140092]; chromatin [GO:0000785]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; GBAF complex [GO:0140288]; kinetochore [GO:0000776]; membrane [GO:0016020]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; lysine-acetylated histone binding [GO:0070577]; nuclear androgen receptor binding [GO:0050681]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; chromatin remodeling [GO:0006338]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural retina development [GO:0003407]; nucleosome disassembly [GO:0006337]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase I preinitiation complex assembly [GO:0001188]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:25593309}. Note=Colocalizes with long non-coding RNA Evf2 in nuclear RNA clouds (By similarity). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000269|PubMed:25593309}.
P51553	reviewed	IDH3G_HUMAN	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma)	IDH3G	Homo sapiens (Human)	393	FUNCTION: Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. {ECO:0000269|PubMed:28139779}.		carbohydrate metabolic process [GO:0005975]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099]	mitochondrial isocitrate dehydrogenase complex (NAD+) [GO:0005962]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	ATP binding [GO:0005524]; isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]	mitochondrial isocitrate dehydrogenase complex (NAD+) [GO:0005962]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; carbohydrate metabolic process [GO:0005975]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11256614}.
P51570	reviewed	GALK1_HUMAN	Galactokinase (EC 2.7.1.6) (Galactose kinase)	GALK1 GALK	Homo sapiens (Human)	392	FUNCTION: Catalyzes the transfer of a phosphate from ATP to alpha-D-galactose and participates in the first committed step in the catabolism of galactose. {ECO:0000269|PubMed:12694189, ECO:0000269|PubMed:7542884}.		galactitol metabolic process [GO:0019402]; galactose catabolic process [GO:0019388]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012]; glycolytic process from galactose [GO:0061623]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	ATP binding [GO:0005524]; galactokinase activity [GO:0004335]; galactose binding [GO:0005534]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; ATP binding [GO:0005524]; galactokinase activity [GO:0004335]; galactose binding [GO:0005534]; galactitol metabolic process [GO:0019402]; galactose catabolic process [GO:0019388]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012]; glycolytic process from galactose [GO:0061623]	
P51571	reviewed	SSRD_HUMAN	Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta)	SSR4 TRAPD	Homo sapiens (Human)	173	FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.			endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Sec61 translocon complex [GO:0005784]		endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Sec61 translocon complex [GO:0005784]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
P51572	reviewed	BAP31_HUMAN	B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (6C6-AG tumor-associated antigen) (Protein CDM) (p28)	BCAP31 BAP31 DXS1357E	Homo sapiens (Human)	246	FUNCTION: Functions as a chaperone protein (PubMed:9396746, PubMed:18287538). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:9396746, PubMed:18287538). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:9396746, PubMed:18287538). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671). {ECO:0000250|UniProtKB:Q61335, ECO:0000269|PubMed:10958671, ECO:0000269|PubMed:18287538, ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:9396746}.		apoptotic process [GO:0006915]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein targeting to mitochondrion [GO:0006626]; response to endoplasmic reticulum stress [GO:0034976]; spermatogenesis [GO:0007283]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]	MHC class I protein binding [GO:0042288]; protein-containing complex binding [GO:0044877]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; MHC class I protein binding [GO:0042288]; protein-containing complex binding [GO:0044877]; apoptotic process [GO:0006915]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein targeting to mitochondrion [GO:0006626]; response to endoplasmic reticulum stress [GO:0034976]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:9334338, ECO:0000269|PubMed:9396746}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:11042173, ECO:0000269|PubMed:9396746}; Multi-pass membrane protein {ECO:0000255}. Note=May shuttle between the ER and the intermediate compartment/cis-Golgi complex (PubMed:9396746). Associates with the mitochondria-associated endoplasmic reticulum membrane via interaction with TOMM40 (PubMed:31206022). {ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:9396746}.; SUBCELLULAR LOCATION: Note=(Microbial infection) Upon SV40 infection, colocalizes with DNAJC18, DNAJB12 and DNAJB14 in punctate structures within the endoplasmic reticulum membrane. {ECO:0000269|PubMed:25631089}.
P51575	reviewed	P2RX1_HUMAN	P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor)	P2RX1 P2X1	Homo sapiens (Human)	399	FUNCTION: Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity). {ECO:0000250}.		apoptotic process [GO:0006915]; calcium ion transmembrane transport [GO:0070588]; ceramide biosynthetic process [GO:0046513]; insemination [GO:0007320]; monoatomic ion transport [GO:0006811]; neuronal action potential [GO:0019228]; platelet activation [GO:0030168]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; regulation of blood pressure [GO:0008217]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of vascular associated smooth muscle contraction [GO:0003056]; response to ATP [GO:0033198]; serotonin secretion by platelet [GO:0002554]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]	external side of plasma membrane [GO:0009897]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]	ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; protein-containing complex binding [GO:0044877]; purinergic nucleotide receptor activity [GO:0001614]; suramin binding [GO:0043924]	external side of plasma membrane [GO:0009897]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; protein-containing complex binding [GO:0044877]; purinergic nucleotide receptor activity [GO:0001614]; suramin binding [GO:0043924]; apoptotic process [GO:0006915]; calcium ion transmembrane transport [GO:0070588]; ceramide biosynthetic process [GO:0046513]; insemination [GO:0007320]; monoatomic ion transport [GO:0006811]; neuronal action potential [GO:0019228]; platelet activation [GO:0030168]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; regulation of blood pressure [GO:0008217]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of vascular associated smooth muscle contraction [GO:0003056]; response to ATP [GO:0033198]; serotonin secretion by platelet [GO:0002554]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P51580	reviewed	TPMT_HUMAN	Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase)	TPMT	Homo sapiens (Human)	245	FUNCTION: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. {ECO:0000269|PubMed:18484748, ECO:0000269|PubMed:657528, ECO:0000305}.		methylation [GO:0032259]; nucleobase-containing compound metabolic process [GO:0006139]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]	S-adenosyl-L-methionine binding [GO:1904047]; thiopurine S-methyltransferase activity [GO:0008119]	cytosol [GO:0005829]; S-adenosyl-L-methionine binding [GO:1904047]; thiopurine S-methyltransferase activity [GO:0008119]; methylation [GO:0032259]; nucleobase-containing compound metabolic process [GO:0006139]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm.
P51582	reviewed	P2RY4_HUMAN	P2Y purinoceptor 4 (P2Y4) (P2P) (Uridine nucleotide receptor) (UNR)	P2RY4 NRU	Homo sapiens (Human)	365	FUNCTION: Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.		cellular response to ATP [GO:0071318]; cellular response to prostaglandin E stimulus [GO:0071380]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle exocytosis [GO:2000300]; transepithelial chloride transport [GO:0030321]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]	ATP binding [GO:0005524]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled UTP receptor activity [GO:0045030]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; ATP binding [GO:0005524]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled UTP receptor activity [GO:0045030]; cellular response to ATP [GO:0071318]; cellular response to prostaglandin E stimulus [GO:0071380]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle exocytosis [GO:2000300]; transepithelial chloride transport [GO:0030321]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P51587	reviewed	BRCA2_HUMAN	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein)	BRCA2 FACD FANCD1	Homo sapiens (Human)	3418	FUNCTION: Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}.		brain development [GO:0007420]; cellular response to ionizing radiation [GO:0071479]; cellular senescence [GO:0090398]; centrosome duplication [GO:0051298]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; establishment of protein localization to telomere [GO:0070200]; female gonad development [GO:0008585]; hematopoietic stem cell proliferation [GO:0071425]; inner cell mass cell proliferation [GO:0001833]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; male meiosis I [GO:0007141]; mitotic recombination-dependent replication fork processing [GO:1990426]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; nucleotide-excision repair [GO:0006289]; oocyte maturation [GO:0001556]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of cytokinesis [GO:0032465]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA-templated transcription [GO:0006355]; response to gamma radiation [GO:0010332]; response to UV-C [GO:0010225]; response to X-ray [GO:0010165]; spermatogenesis [GO:0007283]; telomere maintenance via recombination [GO:0000722]	BRCA2-MAGE-D1 complex [GO:0033593]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; lateral element [GO:0000800]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]	gamma-tubulin binding [GO:0043015]; histone H3 acetyltransferase activity [GO:0010484]; histone H4 acetyltransferase activity [GO:0010485]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; single-stranded DNA binding [GO:0003697]	BRCA2-MAGE-D1 complex [GO:0033593]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; lateral element [GO:0000800]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; gamma-tubulin binding [GO:0043015]; histone H3 acetyltransferase activity [GO:0010484]; histone H4 acetyltransferase activity [GO:0010485]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; single-stranded DNA binding [GO:0003697]; brain development [GO:0007420]; cellular response to ionizing radiation [GO:0071479]; cellular senescence [GO:0090398]; centrosome duplication [GO:0051298]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; establishment of protein localization to telomere [GO:0070200]; female gonad development [GO:0008585]; hematopoietic stem cell proliferation [GO:0071425]; inner cell mass cell proliferation [GO:0001833]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; male meiosis I [GO:0007141]; mitotic recombination-dependent replication fork processing [GO:1990426]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; nucleotide-excision repair [GO:0006289]; oocyte maturation [GO:0001556]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of cytokinesis [GO:0032465]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA-templated transcription [GO:0006355]; response to gamma radiation [GO:0010332]; response to UV-C [GO:0010225]; response to X-ray [GO:0010165]; spermatogenesis [GO:0007283]; telomere maintenance via recombination [GO:0000722]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24013206, ECO:0000269|PubMed:26833090, ECO:0000305|PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}. Note=Colocalizes with ERCC5/XPG to nuclear foci following DNA replication stress. {ECO:0000269|PubMed:26833090}.
P51589	reviewed	CP2J2_HUMAN	Cytochrome P450 2J2 (EC 1.14.14.-) (Albendazole monooxygenase (hydroxylating)) (EC 1.14.14.74) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Arachidonic acid epoxygenase) (CYPIIJ2) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7)	CYP2J2	Homo sapiens (Human)	502	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). {ECO:0000269|PubMed:19737933, ECO:0000269|PubMed:19923256, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:23959307, ECO:0000269|PubMed:8631948}.		epoxygenase P450 pathway [GO:0019373]; fatty acid metabolic process [GO:0006631]; icosanoid metabolic process [GO:0006690]; linoleic acid metabolic process [GO:0043651]; organic acid metabolic process [GO:0006082]; regulation of heart contraction [GO:0008016]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]	arachidonic acid 11,12-epoxygenase activity [GO:0008405]; arachidonic acid 14,15-epoxygenase activity [GO:0008404]; arachidonic acid 5,6-epoxygenase activity [GO:0106301]; arachidonic acid epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate isomerase activity [GO:0106255]; iron ion binding [GO:0005506]; isomerase activity [GO:0016853]; linoleic acid epoxygenase activity [GO:0071614]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; arachidonic acid 11,12-epoxygenase activity [GO:0008405]; arachidonic acid 14,15-epoxygenase activity [GO:0008404]; arachidonic acid 5,6-epoxygenase activity [GO:0106301]; arachidonic acid epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate isomerase activity [GO:0106255]; iron ion binding [GO:0005506]; isomerase activity [GO:0016853]; linoleic acid epoxygenase activity [GO:0071614]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; epoxygenase P450 pathway [GO:0019373]; fatty acid metabolic process [GO:0006631]; icosanoid metabolic process [GO:0006690]; linoleic acid metabolic process [GO:0043651]; organic acid metabolic process [GO:0006082]; regulation of heart contraction [GO:0008016]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:8631948}; Peripheral membrane protein.
P51606	reviewed	RENBP_HUMAN	N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP)	RENBP	Homo sapiens (Human)	417	FUNCTION: Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine (PubMed:9990133, PubMed:10502668, PubMed:12499362). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:9990133). {ECO:0000269|PubMed:10502668, ECO:0000269|PubMed:12499362, ECO:0000269|PubMed:9990133}.		carbohydrate metabolic process [GO:0005975]; N-acetylglucosamine metabolic process [GO:0006044]; N-acetylmannosamine metabolic process [GO:0006051]; N-acetylneuraminate catabolic process [GO:0019262]; regulation of blood pressure [GO:0008217]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	endopeptidase inhibitor activity [GO:0004866]; identical protein binding [GO:0042802]; N-acylglucosamine 2-epimerase activity [GO:0050121]; peptidase inhibitor activity [GO:0030414]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; endopeptidase inhibitor activity [GO:0004866]; identical protein binding [GO:0042802]; N-acylglucosamine 2-epimerase activity [GO:0050121]; peptidase inhibitor activity [GO:0030414]; carbohydrate metabolic process [GO:0005975]; N-acetylglucosamine metabolic process [GO:0006044]; N-acetylmannosamine metabolic process [GO:0006051]; N-acetylneuraminate catabolic process [GO:0019262]; regulation of blood pressure [GO:0008217]	
P51608	reviewed	MECP2_HUMAN	Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)	MECP2	Homo sapiens (Human)	486	FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}.	MISCELLANEOUS: [Isoform B]: Ten times higher expression levels than isoform A in brain. {ECO:0000305}.	adult locomotory behavior [GO:0008344]; behavioral fear response [GO:0001662]; biogenic amine metabolic process [GO:0006576]; cardiolipin metabolic process [GO:0032048]; catecholamine secretion [GO:0050432]; cellular response to isoquinoline alkaloid [GO:0071317]; cellular response to potassium ion [GO:0035865]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; excitatory postsynaptic potential [GO:0060079]; gene expression [GO:0010467]; glial cell proliferation [GO:0014009]; glucocorticoid metabolic process [GO:0008211]; glutamine metabolic process [GO:0006541]; heart development [GO:0007507]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; inositol metabolic process [GO:0006020]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; lung alveolus development [GO:0048286]; mitotic spindle organization [GO:0007052]; negative regulation of angiogenesis [GO:0016525]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of dendrite extension [GO:1903860]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of primary miRNA processing [GO:2000635]; negative regulation of respiratory gaseous exchange [GO:1903941]; negative regulation of smooth muscle cell differentiation [GO:0051151]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [GO:2000820]; nervous system process involved in regulation of systemic arterial blood pressure [GO:0001976]; neuron maturation [GO:0042551]; Notch signaling pathway [GO:0007219]; olfactory bulb development [GO:0021772]; oligodendrocyte development [GO:0014003]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of anterograde dense core granule transport [GO:1901953]; positive regulation of branching morphogenesis of a nerve [GO:1905492]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of DNA methylation [GO:1905643]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of retrograde dense core granule transport [GO:1901956]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; proprioception [GO:0019230]; protein localization [GO:0008104]; regulation of action potential firing threshold [GO:0099611]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of histone H3-K9 methylation [GO:0051570]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of synapse organization [GO:0050807]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to lead ion [GO:0010288]; response to other organism [GO:0051707]; sensory perception of pain [GO:0019233]; social behavior [GO:0035176]; spinal cord development [GO:0021510]; startle response [GO:0001964]; striatum development [GO:0021756]; synapse assembly [GO:0007416]; thalamus development [GO:0021794]; trans-synaptic signaling by BDNF [GO:0099191]; ventricular system development [GO:0021591]; visual learning [GO:0008542]	centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]	chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; double-stranded methylated DNA binding [GO:0010385]; four-way junction DNA binding [GO:0000400]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; nucleic acid binding [GO:0003676]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; siRNA binding [GO:0035197]; transcription corepressor activity [GO:0003714]; unmethylated CpG binding [GO:0045322]	centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; double-stranded methylated DNA binding [GO:0010385]; four-way junction DNA binding [GO:0000400]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; nucleic acid binding [GO:0003676]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; siRNA binding [GO:0035197]; transcription corepressor activity [GO:0003714]; unmethylated CpG binding [GO:0045322]; adult locomotory behavior [GO:0008344]; behavioral fear response [GO:0001662]; biogenic amine metabolic process [GO:0006576]; cardiolipin metabolic process [GO:0032048]; catecholamine secretion [GO:0050432]; cellular response to isoquinoline alkaloid [GO:0071317]; cellular response to potassium ion [GO:0035865]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; excitatory postsynaptic potential [GO:0060079]; gene expression [GO:0010467]; glial cell proliferation [GO:0014009]; glucocorticoid metabolic process [GO:0008211]; glutamine metabolic process [GO:0006541]; heart development [GO:0007507]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; inositol metabolic process [GO:0006020]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; lung alveolus development [GO:0048286]; mitotic spindle organization [GO:0007052]; negative regulation of angiogenesis [GO:0016525]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of dendrite extension [GO:1903860]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of primary miRNA processing [GO:2000635]; negative regulation of respiratory gaseous exchange [GO:1903941]; negative regulation of smooth muscle cell differentiation [GO:0051151]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [GO:2000820]; nervous system process involved in regulation of systemic arterial blood pressure [GO:0001976]; neuron maturation [GO:0042551]; Notch signaling pathway [GO:0007219]; olfactory bulb development [GO:0021772]; oligodendrocyte development [GO:0014003]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of anterograde dense core granule transport [GO:1901953]; positive regulation of branching morphogenesis of a nerve [GO:1905492]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of DNA methylation [GO:1905643]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of retrograde dense core granule transport [GO:1901956]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; proprioception [GO:0019230]; protein localization [GO:0008104]; regulation of action potential firing threshold [GO:0099611]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of histone H3-K9 methylation [GO:0051570]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of synapse organization [GO:0050807]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to lead ion [GO:0010288]; response to other organism [GO:0051707]; sensory perception of pain [GO:0019233]; social behavior [GO:0035176]; spinal cord development [GO:0021510]; startle response [GO:0001964]; striatum development [GO:0021756]; synapse assembly [GO:0007416]; thalamus development [GO:0021794]; trans-synaptic signaling by BDNF [GO:0099191]; ventricular system development [GO:0021591]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Z2D6}. Note=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. {ECO:0000269|PubMed:28348241}.
P51610	reviewed	HCFC1_HUMAN	Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]	HCFC1 HCF1 HFC1	Homo sapiens (Human)	2035	FUNCTION: Transcriptional coregulator (By similarity). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}.	MISCELLANEOUS: [Isoform 2]: The N- and the C-terminal fragments fail to associate. {ECO:0000305}.	cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; regulation of protein-containing complex assembly [GO:0043254]; release from viral latency [GO:0019046]	cytoplasm [GO:0005737]; histone acetyltransferase complex [GO:0000123]; histone methyltransferase complex [GO:0035097]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; neuronal cell body [GO:0043025]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; Set1C/COMPASS complex [GO:0048188]	cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; histone acetyltransferase complex [GO:0000123]; histone methyltransferase complex [GO:0035097]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; neuronal cell body [GO:0043025]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; Set1C/COMPASS complex [GO:0048188]; cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; regulation of protein-containing complex assembly [GO:0043254]; release from viral latency [GO:0019046]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12235138}. Nucleus {ECO:0000269|PubMed:10623756, ECO:0000269|PubMed:12235138, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21285374, ECO:0000269|PubMed:23629655}. Note=HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm (PubMed:12235138). Non-processed HCFC1 associates with chromatin. Colocalizes with CREB3 and CANX in the ER. {ECO:0000269|PubMed:12235138}.
P51617	reviewed	IRAK1_HUMAN	Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)	IRAK1 IRAK	Homo sapiens (Human)	712	FUNCTION: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}.	MISCELLANEOUS: [Isoform 2]: Inactive. {ECO:0000305}.	activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; cellular response to lipopolysaccharide [GO:0071222]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of type I interferon production [GO:0032481]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cytokine-mediated signaling pathway [GO:0001959]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; Toll signaling pathway [GO:0008063]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; type I interferon-mediated signaling pathway [GO:0060337]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; NF-kappaB-inducing kinase activity [GO:0004704]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; NF-kappaB-inducing kinase activity [GO:0004704]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; cellular response to lipopolysaccharide [GO:0071222]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of type I interferon production [GO:0032481]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cytokine-mediated signaling pathway [GO:0001959]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; Toll signaling pathway [GO:0008063]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16690127}. Nucleus {ECO:0000269|PubMed:16690127}. Lipid droplet {ECO:0000250}. Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
P51636	reviewed	CAV2_HUMAN	Caveolin-2	CAV2	Homo sapiens (Human)	162	FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). {ECO:0000250, ECO:0000269|PubMed:15504032, ECO:0000269|PubMed:18081315}.	MISCELLANEOUS: [Isoform Beta]: Produced by alternative initiation. {ECO:0000305}.; MISCELLANEOUS: [Isoform C]: Produced by alternative splicing. {ECO:0000305}.	basement membrane organization [GO:0071711]; caveola assembly [GO:0070836]; cell differentiation [GO:0030154]; endoplasmic reticulum organization [GO:0007029]; endothelial cell proliferation [GO:0001935]; insulin receptor signaling pathway [GO:0008286]; mitochondrion organization [GO:0007005]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of skeletal muscle cell proliferation [GO:0014859]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation by host of viral process [GO:0044794]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAPK cascade [GO:0043410]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of mitotic nuclear division [GO:0007088]; skeletal muscle cell proliferation [GO:0014856]; skeletal muscle fiber development [GO:0048741]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]; vesicle organization [GO:0016050]; viral release from host cell [GO:0019076]	acrosomal membrane [GO:0002080]; caveola [GO:0005901]; caveolar macromolecular signaling complex [GO:0002095]; cytoplasmic vesicle [GO:0031410]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; protein-containing complex [GO:0032991]; transport vesicle [GO:0030133]	D1 dopamine receptor binding [GO:0031748]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; scaffold protein binding [GO:0097110]	acrosomal membrane [GO:0002080]; caveola [GO:0005901]; caveolar macromolecular signaling complex [GO:0002095]; cytoplasmic vesicle [GO:0031410]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; protein-containing complex [GO:0032991]; transport vesicle [GO:0030133]; D1 dopamine receptor binding [GO:0031748]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; scaffold protein binding [GO:0097110]; basement membrane organization [GO:0071711]; caveola assembly [GO:0070836]; cell differentiation [GO:0030154]; endoplasmic reticulum organization [GO:0007029]; endothelial cell proliferation [GO:0001935]; insulin receptor signaling pathway [GO:0008286]; mitochondrion organization [GO:0007005]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of skeletal muscle cell proliferation [GO:0014859]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation by host of viral process [GO:0044794]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAPK cascade [GO:0043410]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of mitotic nuclear division [GO:0007088]; skeletal muscle cell proliferation [GO:0014856]; skeletal muscle fiber development [GO:0048741]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]; vesicle organization [GO:0016050]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. {ECO:0000250}.
P51648	reviewed	AL3A2_HUMAN	Aldehyde dehydrogenase family 3 member A2 (EC 1.2.1.3) (EC 1.2.1.94) (Aldehyde dehydrogenase 10) (Fatty aldehyde dehydrogenase) (Microsomal aldehyde dehydrogenase)	ALDH3A2 ALDH10 FALDH	Homo sapiens (Human)	485	FUNCTION: Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). {ECO:0000269|PubMed:18035827, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:25047030, ECO:0000269|PubMed:9133646, ECO:0000269|PubMed:9662422}.		cellular aldehyde metabolic process [GO:0006081]; central nervous system development [GO:0007417]; epidermis development [GO:0008544]; fatty acid metabolic process [GO:0006631]; hexadecanal metabolic process [GO:0046458]; peripheral nervous system development [GO:0007422]; phytol metabolic process [GO:0033306]; sesquiterpenoid metabolic process [GO:0006714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; long-chain-alcohol oxidase activity [GO:0046577]; long-chain-aldehyde dehydrogenase activity [GO:0050061]; medium-chain-aldehyde dehydrogenase activity [GO:0052814]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; long-chain-alcohol oxidase activity [GO:0046577]; long-chain-aldehyde dehydrogenase activity [GO:0050061]; medium-chain-aldehyde dehydrogenase activity [GO:0052814]; protein homodimerization activity [GO:0042803]; cellular aldehyde metabolic process [GO:0006081]; central nervous system development [GO:0007417]; epidermis development [GO:0008544]; fatty acid metabolic process [GO:0006631]; hexadecanal metabolic process [GO:0046458]; peripheral nervous system development [GO:0007422]; phytol metabolic process [GO:0033306]; sesquiterpenoid metabolic process [GO:0006714]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:9133646}; Single-pass membrane protein {ECO:0000305|PubMed:25047030, ECO:0000305|PubMed:9133646}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:9133646}; Single-pass membrane protein {ECO:0000305|PubMed:25047030, ECO:0000305|PubMed:9133646}; Cytoplasmic side {ECO:0000250|UniProtKB:P30839}.
P51649	reviewed	SSDH_HUMAN	Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)	ALDH5A1 SSADH	Homo sapiens (Human)	535	FUNCTION: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). {ECO:0000269|PubMed:19300440}.		central nervous system development [GO:0007417]; gamma-aminobutyric acid catabolic process [GO:0009450]; glutamate metabolic process [GO:0006536]; neurotransmitter catabolic process [GO:0042135]; post-embryonic development [GO:0009791]; succinate metabolic process [GO:0006105]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	identical protein binding [GO:0042802]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; identical protein binding [GO:0042802]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]; central nervous system development [GO:0007417]; gamma-aminobutyric acid catabolic process [GO:0009450]; glutamate metabolic process [GO:0006536]; neurotransmitter catabolic process [GO:0042135]; post-embryonic development [GO:0009791]; succinate metabolic process [GO:0006105]	SUBCELLULAR LOCATION: Mitochondrion.
P51654	reviewed	GPC3_HUMAN	Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]	GPC3 OCI5	Homo sapiens (Human)	580	FUNCTION: Cell surface proteoglycan (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity). {ECO:0000250|UniProtKB:Q6V9Y8, ECO:0000250|UniProtKB:Q8CFZ4, ECO:0000269|PubMed:14610063, ECO:0000269|PubMed:16227623, ECO:0000269|PubMed:17549790, ECO:0000269|PubMed:24496449}.	MISCELLANEOUS: Used as a marker for hepatocellular carcinoma (HCC) as it is expressed in HCC but is not detectable in hepatocytes from normal or benign liver diseases (PubMed:12851874). When attached to the cell surface, stimulates the growth of HCC cells by increasing canonical Wnt signaling (PubMed:16024626). Cleavage is not required for stimulation of Wnt signaling or HCC growth (PubMed:16227623). {ECO:0000269|PubMed:12851874, ECO:0000269|PubMed:16024626, ECO:0000269|PubMed:16227623}.	anatomical structure morphogenesis [GO:0009653]; anterior/posterior axis specification [GO:0009948]; body morphogenesis [GO:0010171]; bone mineralization [GO:0030282]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; cell migration involved in gastrulation [GO:0042074]; cell proliferation involved in kidney development [GO:0072111]; cell proliferation involved in metanephros development [GO:0072203]; coronary vasculature development [GO:0060976]; embryonic hindlimb morphogenesis [GO:0035116]; epithelial cell proliferation [GO:0050673]; lung development [GO:0030324]; mesenchymal cell proliferation involved in ureteric bud development [GO:0072138]; mesonephric duct morphogenesis [GO:0072180]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of growth [GO:0045926]; negative regulation of smoothened signaling pathway [GO:0045879]; osteoclast differentiation [GO:0030316]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endocytosis [GO:0045807]; positive regulation of glucose import [GO:0046326]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of non-canonical Wnt signaling pathway [GO:2000050]; regulation of protein localization to membrane [GO:1905475]; response to bacterium [GO:0009617]; smoothened signaling pathway [GO:0007224]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	peptidyl-dipeptidase inhibitor activity [GO:0060422]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; peptidyl-dipeptidase inhibitor activity [GO:0060422]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior axis specification [GO:0009948]; body morphogenesis [GO:0010171]; bone mineralization [GO:0030282]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; cell migration involved in gastrulation [GO:0042074]; cell proliferation involved in kidney development [GO:0072111]; cell proliferation involved in metanephros development [GO:0072203]; coronary vasculature development [GO:0060976]; embryonic hindlimb morphogenesis [GO:0035116]; epithelial cell proliferation [GO:0050673]; lung development [GO:0030324]; mesenchymal cell proliferation involved in ureteric bud development [GO:0072138]; mesonephric duct morphogenesis [GO:0072180]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of growth [GO:0045926]; negative regulation of smoothened signaling pathway [GO:0045879]; osteoclast differentiation [GO:0030316]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endocytosis [GO:0045807]; positive regulation of glucose import [GO:0046326]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of non-canonical Wnt signaling pathway [GO:2000050]; regulation of protein localization to membrane [GO:1905475]; response to bacterium [GO:0009617]; smoothened signaling pathway [GO:0007224]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14610063}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P13265}; Extracellular side {ECO:0000250|UniProtKB:P13265}.
P51659	reviewed	DHB4_HUMAN	Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]	HSD17B4 EDH17B4 SDR8C1	Homo sapiens (Human)	736	FUNCTION: Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}.	MISCELLANEOUS: The protein is found both as a full-length peptide and in a cleaved version.	androgen metabolic process [GO:0008209]; estrogen metabolic process [GO:0008210]; fatty acid beta-oxidation [GO:0006635]; medium-chain fatty-acyl-CoA metabolic process [GO:0036112]; osteoblast differentiation [GO:0001649]; Sertoli cell development [GO:0060009]; very long-chain fatty acid metabolic process [GO:0000038]; very long-chain fatty-acyl-CoA metabolic process [GO:0036111]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity [GO:0106386]; 17-beta-hydroxysteroid dehydrogenase (NAD+) activity [GO:0044594]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity [GO:0033989]; enoyl-CoA hydratase activity [GO:0004300]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; isomerase activity [GO:0016853]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; (3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity [GO:0106386]; 17-beta-hydroxysteroid dehydrogenase (NAD+) activity [GO:0044594]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity [GO:0033989]; enoyl-CoA hydratase activity [GO:0004300]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; isomerase activity [GO:0016853]; protein homodimerization activity [GO:0042803]; androgen metabolic process [GO:0008209]; estrogen metabolic process [GO:0008210]; fatty acid beta-oxidation [GO:0006635]; medium-chain fatty-acyl-CoA metabolic process [GO:0036112]; osteoblast differentiation [GO:0001649]; Sertoli cell development [GO:0060009]; very long-chain fatty acid metabolic process [GO:0000038]; very long-chain fatty-acyl-CoA metabolic process [GO:0036111]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000305}.
P51665	reviewed	PSMD7_HUMAN	26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Mov34 protein homolog) (Proteasome subunit p40)	PSMD7 MOV34L	Homo sapiens (Human)	324	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.	MISCELLANEOUS: Does not bind a metal ion.	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; secretory granule lumen [GO:0034774]	protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; secretory granule lumen [GO:0034774]; protein homodimerization activity [GO:0042803]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	
P51668	reviewed	UB2D1_HUMAN	Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)	UBE2D1 SFT UBC5A UBCH5 UBCH5A	Homo sapiens (Human)	147	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). {ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:22496338}.		negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18845142}.
P51671	reviewed	CCL11_HUMAN	Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)	CCL11 SCYA11	Homo sapiens (Human)	97	FUNCTION: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions (PubMed:8597956). Binds to CCR3 (PubMed:8631813). {ECO:0000269|PubMed:8597956, ECO:0000269|PubMed:8631813}.		cell adhesion [GO:0007155]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; learning or memory [GO:0007611]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; negative regulation of neurogenesis [GO:0050768]; neutrophil chemotaxis [GO:0030593]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; response to radiation [GO:0009314]; response to virus [GO:0009615]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR3 chemokine receptor binding [GO:0031728]; chemokine activity [GO:0008009]; protein dimerization activity [GO:0046983]; receptor ligand activity [GO:0048018]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR3 chemokine receptor binding [GO:0031728]; chemokine activity [GO:0008009]; protein dimerization activity [GO:0046983]; receptor ligand activity [GO:0048018]; cell adhesion [GO:0007155]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; learning or memory [GO:0007611]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; negative regulation of neurogenesis [GO:0050768]; neutrophil chemotaxis [GO:0030593]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; response to radiation [GO:0009314]; response to virus [GO:0009615]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:8597956}.
P51674	reviewed	GPM6A_HUMAN	Neuronal membrane glycoprotein M6-a (M6a)	GPM6A M6A	Homo sapiens (Human)	278	FUNCTION: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO:0000269|PubMed:19298174}.		neural retina development [GO:0003407]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; positive regulation of filopodium assembly [GO:0051491]; regulation of synapse organization [GO:0050807]; response to bacterium [GO:0009617]; stem cell differentiation [GO:0048863]; synapse assembly [GO:0007416]	axonal growth cone [GO:0044295]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]	calcium channel activity [GO:0005262]	axonal growth cone [GO:0044295]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; calcium channel activity [GO:0005262]; neural retina development [GO:0003407]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; positive regulation of filopodium assembly [GO:0051491]; regulation of synapse organization [GO:0050807]; response to bacterium [GO:0009617]; stem cell differentiation [GO:0048863]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P35802}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35802}. Cell projection, axon {ECO:0000250|UniProtKB:P35802}. Cell projection, growth cone {ECO:0000250|UniProtKB:P35802}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q812E9}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q812E9}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q812E9}. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (By similarity). Localized to the growth cone edge membrane of elongating axons (By similarity). {ECO:0000250|UniProtKB:P35802, ECO:0000250|UniProtKB:Q812E9}.
P51677	reviewed	CCR3_HUMAN	C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)	CCR3 CMKBR3	Homo sapiens (Human)	355	FUNCTION: Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064). Subsequently transduces a signal by increasing the intracellular calcium ions level (PubMed:8676064). In addition acts as a possible functional receptor for NARS1 (PubMed:30171954). {ECO:0000269|PubMed:30171954, ECO:0000269|PubMed:7622448, ECO:0000269|PubMed:8642344, ECO:0000269|PubMed:8676064}.; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:9789057}.	MISCELLANEOUS: Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277). {ECO:0000305|PubMed:21077277}.	adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of endothelial cell proliferation [GO:0001938]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of endothelial cell proliferation [GO:0001938]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000255}.
P51679	reviewed	CCR4_HUMAN	C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)	CCR4 CMKBR4	Homo sapiens (Human)	360	FUNCTION: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000269|PubMed:10466728, ECO:0000269|PubMed:10754297, ECO:0000269|PubMed:16137713, ECO:0000269|PubMed:9169480, ECO:0000269|PubMed:9430724}.		calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; homeostasis of number of cells [GO:0048872]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interneuron migration [GO:1904936]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of positive chemotaxis [GO:0050927]; response to bacterium [GO:0009617]; tolerance induction [GO:0002507]	external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]	external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; homeostasis of number of cells [GO:0048872]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interneuron migration [GO:1904936]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of positive chemotaxis [GO:0050927]; response to bacterium [GO:0009617]; tolerance induction [GO:0002507]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P51681	reviewed	CCR5_HUMAN	C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)	CCR5 CMKBR5	Homo sapiens (Human)	352	FUNCTION: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770). {ECO:0000269|PubMed:10383387, ECO:0000269|PubMed:11323418, ECO:0000269|PubMed:30713770, ECO:0000269|PubMed:8639485, ECO:0000269|PubMed:8663314, ECO:0000269|PubMed:8699119}.; FUNCTION: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1. {ECO:0000269|PubMed:10383387, ECO:0000269|PubMed:21763489, ECO:0000269|PubMed:8649511, ECO:0000269|PubMed:8649512, ECO:0000269|PubMed:9632396}.		calcium ion transport [GO:0006816]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; negative regulation of macrophage apoptotic process [GO:2000110]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to cholesterol [GO:0070723]; signaling [GO:0023052]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine (C-C motif) ligand 5 binding [GO:0071791]; chemokine receptor activity [GO:0004950]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; phosphatidylinositol phospholipase C activity [GO:0004435]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine (C-C motif) ligand 5 binding [GO:0071791]; chemokine receptor activity [GO:0004950]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; phosphatidylinositol phospholipase C activity [GO:0004435]; virus receptor activity [GO:0001618]; calcium ion transport [GO:0006816]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; negative regulation of macrophage apoptotic process [GO:2000110]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to cholesterol [GO:0070723]; signaling [GO:0023052]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10383387, ECO:0000269|PubMed:11323418}; Multi-pass membrane protein {ECO:0000269|PubMed:11323418}.
P51684	reviewed	CCR6_HUMAN	C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (Chemokine receptor-like 3) (CKR-L3) (DRY6) (G-protein coupled receptor 29) (GPR-CY4) (GPRCY4) (LARC receptor) (CD antigen CD196)	CCR6 CKRL3 CMKBR6 GPR29 STRL22	Homo sapiens (Human)	374	FUNCTION: Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988). {ECO:0000250|UniProtKB:O54689, ECO:0000269|PubMed:20068036, ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:25122636, ECO:0000269|PubMed:9169459, ECO:0000303|PubMed:21376174, ECO:0000303|PubMed:25585877}.		calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; DN2 thymocyte differentiation [GO:1904155]; DN3 thymocyte differentiation [GO:1904156]; humoral immune response [GO:0006959]; immune response [GO:0006955]; isotype switching to IgA isotypes [GO:0048290]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte migration [GO:0072676]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of flagellated sperm motility involved in capacitation [GO:0060474]; regulation of T cell migration [GO:2000404]; signal transduction [GO:0007165]; T cell migration [GO:0072678]; thymocyte migration [GO:0072679]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm plasma membrane [GO:0097524]; sperm principal piece [GO:0097228]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm plasma membrane [GO:0097524]; sperm principal piece [GO:0097228]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; signaling receptor activity [GO:0038023]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; DN2 thymocyte differentiation [GO:1904155]; DN3 thymocyte differentiation [GO:1904156]; humoral immune response [GO:0006959]; immune response [GO:0006955]; isotype switching to IgA isotypes [GO:0048290]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte migration [GO:0072676]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of flagellated sperm motility involved in capacitation [GO:0060474]; regulation of T cell migration [GO:2000404]; signal transduction [GO:0007165]; T cell migration [GO:0072678]; thymocyte migration [GO:0072679]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23765988}; Multi-pass membrane protein {ECO:0000255}. Cell surface {ECO:0000269|PubMed:12081481}.
P51685	reviewed	CCR8_HUMAN	C-C chemokine receptor type 8 (C-C CKR-8) (CC-CKR-8) (CCR-8) (CC chemokine receptor CHEMR1) (CMKBRL2) (Chemokine receptor-like 1) (CKR-L1) (GPR-CY6) (GPRCY6) (TER1) (CD antigen CDw198)	CCR8 CKRL1 CMKBR8 CMKBRL2	Homo sapiens (Human)	355	FUNCTION: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:9207005, ECO:0000269|PubMed:9469461, ECO:0000269|PubMed:9521068}.		calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; coreceptor activity [GO:0015026]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; coreceptor activity [GO:0015026]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P51686	reviewed	CCR9_HUMAN	C-C chemokine receptor type 9 (C-C CKR-9) (CC-CKR-9) (CCR-9) (G-protein coupled receptor 28) (GPR-9-6) (CD antigen CDw199)	CCR9 GPR28	Homo sapiens (Human)	369	FUNCTION: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. {ECO:0000269|PubMed:10229797, ECO:0000269|PubMed:10640743}.; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.	MISCELLANEOUS: EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2.	calcium-mediated signaling [GO:0019722]; CD8-positive, gamma-delta intraepithelial T cell differentiation [GO:0002305]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; calcium-mediated signaling [GO:0019722]; CD8-positive, gamma-delta intraepithelial T cell differentiation [GO:0002305]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:27926729}; Multi-pass membrane protein {ECO:0000305|PubMed:27926729}.
P51687	reviewed	SUOX_HUMAN	Sulfite oxidase, mitochondrial (EC 1.8.3.1)	SUOX	Homo sapiens (Human)	545	FUNCTION: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids. {ECO:0000250|UniProtKB:Q07116}.		sulfur compound metabolic process [GO:0006790]	mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	heme binding [GO:0020037]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; sulfite oxidase activity [GO:0008482]	mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; heme binding [GO:0020037]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; sulfite oxidase activity [GO:0008482]; sulfur compound metabolic process [GO:0006790]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q07116}.
P51688	reviewed	SPHM_HUMAN	N-sulphoglucosamine sulphohydrolase (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase)	SGSH HSS	Homo sapiens (Human)	502	FUNCTION: Catalyzes a step in lysosomal heparan sulfate degradation. {ECO:0000269|PubMed:15146460, ECO:0000269|PubMed:24816101, ECO:0000269|PubMed:7493035}.		determination of adult lifespan [GO:0008340]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; motor behavior [GO:0061744]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	metal ion binding [GO:0046872]; N-sulfoglucosamine sulfohydrolase activity [GO:0016250]; sulfuric ester hydrolase activity [GO:0008484]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; metal ion binding [GO:0046872]; N-sulfoglucosamine sulfohydrolase activity [GO:0016250]; sulfuric ester hydrolase activity [GO:0008484]; determination of adult lifespan [GO:0008340]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; motor behavior [GO:0061744]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:15146460}.
P51690	reviewed	ARSL_HUMAN	Arylsulfatase L (EC 3.1.6.1) (Arylsulfatase E) (ASE)	ARSL ARSE	Homo sapiens (Human)	589	FUNCTION: Exhibits arylsulfatase activity towards the artificial substrate 4-methylumbelliferyl sulfate (PubMed:7720070, PubMed:9497243). May be essential for the correct composition of cartilage and bone matrix during development (PubMed:7720070). Has no activity toward steroid sulfates (PubMed:7720070). {ECO:0000269|PubMed:7720070, ECO:0000269|PubMed:9497243}.		skeletal system development [GO:0001501]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]	arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack {ECO:0000269|PubMed:9497243}.
P51692	reviewed	STA5B_HUMAN	Signal transducer and activator of transcription 5B	STAT5B	Homo sapiens (Human)	787	FUNCTION: Carries out a dual function: signal transduction and activation of transcription (PubMed:29844444). Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. {ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:29844444, ECO:0000269|PubMed:8732682}.		activated T cell proliferation [GO:0050798]; B cell differentiation [GO:0030183]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hormone stimulus [GO:0032870]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; development of secondary female sexual characteristics [GO:0046543]; development of secondary male sexual characteristics [GO:0046544]; erythrocyte differentiation [GO:0030218]; female pregnancy [GO:0007565]; gamma-delta T cell differentiation [GO:0042492]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; lactation [GO:0007595]; lipid storage [GO:0019915]; luteinization [GO:0001553]; mast cell migration [GO:0097531]; mitotic cell cycle [GO:0000278]; myeloid cell apoptotic process [GO:0033028]; natural killer cell differentiation [GO:0001779]; natural killer cell mediated cytotoxicity [GO:0042267]; natural killer cell proliferation [GO:0001787]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of myeloid cell apoptotic process [GO:0033033]; Peyer's patch development [GO:0048541]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone metabolic process [GO:0042448]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell population proliferation [GO:0042127]; regulation of epithelial cell differentiation [GO:0030856]; regulation of multicellular organism growth [GO:0040014]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to interleukin-15 [GO:0070672]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to peptide hormone [GO:0043434]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; taurine metabolic process [GO:0019530]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; nuclear glucocorticoid receptor binding [GO:0035259]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; nuclear glucocorticoid receptor binding [GO:0035259]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; activated T cell proliferation [GO:0050798]; B cell differentiation [GO:0030183]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hormone stimulus [GO:0032870]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; development of secondary female sexual characteristics [GO:0046543]; development of secondary male sexual characteristics [GO:0046544]; erythrocyte differentiation [GO:0030218]; female pregnancy [GO:0007565]; gamma-delta T cell differentiation [GO:0042492]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; lactation [GO:0007595]; lipid storage [GO:0019915]; luteinization [GO:0001553]; mast cell migration [GO:0097531]; mitotic cell cycle [GO:0000278]; myeloid cell apoptotic process [GO:0033028]; natural killer cell differentiation [GO:0001779]; natural killer cell mediated cytotoxicity [GO:0042267]; natural killer cell proliferation [GO:0001787]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of myeloid cell apoptotic process [GO:0033033]; Peyer's patch development [GO:0048541]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone metabolic process [GO:0042448]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell population proliferation [GO:0042127]; regulation of epithelial cell differentiation [GO:0030856]; regulation of multicellular organism growth [GO:0040014]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to interleukin-15 [GO:0070672]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to peptide hormone [GO:0043434]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; taurine metabolic process [GO:0019530]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29844444}. Nucleus {ECO:0000269|PubMed:29844444}. Note=Translocated into the nucleus in response to phosphorylation. {ECO:0000269|PubMed:29844444}.
P51693	reviewed	APLP1_HUMAN	Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30]	APLP1	Homo sapiens (Human)	650	FUNCTION: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. {ECO:0000250}.; FUNCTION: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. {ECO:0000250}.	MISCELLANEOUS: Binds zinc and copper in the extracellular domain. Zinc-binding increases heparin binding. No Cu(2+) reducing activity with copper-binding.	animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cellular response to norepinephrine stimulus [GO:0071874]; central nervous system development [GO:0007417]; cytoplasmic polyadenylation [GO:0180011]; endocytosis [GO:0006897]; extracellular matrix organization [GO:0030198]; forebrain development [GO:0030900]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; nervous system development [GO:0007399]; regulation of translation [GO:0006417]	basement membrane [GO:0005604]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	alpha-2A adrenergic receptor binding [GO:0031694]; alpha-2B adrenergic receptor binding [GO:0031695]; alpha-2C adrenergic receptor binding [GO:0031696]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; transition metal ion binding [GO:0046914]	basement membrane [GO:0005604]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; alpha-2A adrenergic receptor binding [GO:0031694]; alpha-2B adrenergic receptor binding [GO:0031695]; alpha-2C adrenergic receptor binding [GO:0031696]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; transition metal ion binding [GO:0046914]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cellular response to norepinephrine stimulus [GO:0071874]; central nervous system development [GO:0007417]; cytoplasmic polyadenylation [GO:0180011]; endocytosis [GO:0006897]; extracellular matrix organization [GO:0030198]; forebrain development [GO:0030900]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; nervous system development [GO:0007399]; regulation of translation [GO:0006417]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [C30]: Cytoplasm. Note=C-terminally processed in the Golgi complex.
P51784	reviewed	UBP11_HUMAN	Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11)	USP11 UHX1	Homo sapiens (Human)	963	FUNCTION: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:28992046, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Promotes cell proliferation by deubiquitinating phosphorylated E2F1 (PubMed:28992046). {ECO:0000269|PubMed:15314155, ECO:0000269|PubMed:17897950, ECO:0000269|PubMed:18408009, ECO:0000269|PubMed:19874889, ECO:0000269|PubMed:20233726, ECO:0000269|PubMed:24724799, ECO:0000269|PubMed:28992046}.		protein deubiquitination [GO:0016579]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; transcription corepressor binding [GO:0001222]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; transcription corepressor binding [GO:0001222]; protein deubiquitination [GO:0016579]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12084015, ECO:0000269|PubMed:15314155, ECO:0000269|PubMed:20233726, ECO:0000269|PubMed:28992046}. Cytoplasm {ECO:0000269|PubMed:15314155, ECO:0000269|PubMed:28992046}. Chromosome {ECO:0000269|PubMed:20233726, ECO:0000269|PubMed:20601937}. Note=Predominantly nuclear (PubMed:12084015, PubMed:15314155). Associates with chromatin (PubMed:20601937, PubMed:20233726). {ECO:0000269|PubMed:12084015, ECO:0000269|PubMed:15314155, ECO:0000269|PubMed:20233726, ECO:0000269|PubMed:20601937}.
P51787	reviewed	KCNQ1_HUMAN	Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)	KCNQ1 KCNA8 KCNA9 KVLQT1	Homo sapiens (Human)	676	FUNCTION: Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (PubMed:10646604, PubMed:25441029). Associates with KCNE beta subunits that modulates current kinetics (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505, PubMed:19687231). Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505, PubMed:25441029). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability. {ECO:0000250|UniProtKB:P97414, ECO:0000250|UniProtKB:Q9Z0N7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:11101505, ECO:0000269|PubMed:12324418, ECO:0000269|PubMed:19687231, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:25037568, ECO:0000269|PubMed:8900283, ECO:0000269|PubMed:9108097, ECO:0000269|PubMed:9312006}.; FUNCTION: [Isoform 2]: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. {ECO:0000269|PubMed:9305853}.	MISCELLANEOUS: Mutagenesis experiments were carried out by expressing in Xenopus oocytes or COS-7 cells KCNQ1 mutants either individually (homomultimers) or in combination with both wild-type KCNQ1 (mut/wt homomultimers) and minK (heteromultimers).	adrenergic receptor signaling pathway [GO:0071875]; atrial cardiac muscle cell action potential [GO:0086014]; auditory receptor cell development [GO:0060117]; cardiac muscle contraction [GO:0060048]; cellular response to cAMP [GO:0071320]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to xenobiotic stimulus [GO:0071466]; cochlea development [GO:0090102]; corticosterone secretion [GO:0035934]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; erythrocyte differentiation [GO:0030218]; gastrin-induced gastric acid secretion [GO:0001698]; gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; heart development [GO:0007507]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; intestinal absorption [GO:0050892]; intracellular chloride ion homeostasis [GO:0030644]; iodide transport [GO:0015705]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; negative regulation of gene expression [GO:0010629]; negative regulation of voltage-gated potassium channel activity [GO:1903817]; non-motile cilium assembly [GO:1905515]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of heart rate [GO:0010460]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export across plasma membrane [GO:0097623]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of blood pressure [GO:0008217]; regulation of gastric acid secretion [GO:0060453]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of heart contraction [GO:0008016]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; renal absorption [GO:0070293]; renal sodium ion absorption [GO:0070294]; response to insulin [GO:0032868]; response to nicotine [GO:0035094]; rhythmic behavior [GO:0007622]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; stomach development [GO:0062094]; ventricular cardiac muscle cell action potential [GO:0086005]	apical plasma membrane [GO:0016324]; basolateral part of cell [GO:1990794]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; monoatomic ion channel complex [GO:0034702]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; voltage-gated potassium channel complex [GO:0008076]	calmodulin binding [GO:0005516]; delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; protein phosphatase 1 binding [GO:0008157]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]	apical plasma membrane [GO:0016324]; basolateral part of cell [GO:1990794]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; monoatomic ion channel complex [GO:0034702]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; voltage-gated potassium channel complex [GO:0008076]; calmodulin binding [GO:0005516]; delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; protein phosphatase 1 binding [GO:0008157]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]; adrenergic receptor signaling pathway [GO:0071875]; atrial cardiac muscle cell action potential [GO:0086014]; auditory receptor cell development [GO:0060117]; cardiac muscle contraction [GO:0060048]; cellular response to cAMP [GO:0071320]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to xenobiotic stimulus [GO:0071466]; cochlea development [GO:0090102]; corticosterone secretion [GO:0035934]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; erythrocyte differentiation [GO:0030218]; gastrin-induced gastric acid secretion [GO:0001698]; gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; heart development [GO:0007507]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; intestinal absorption [GO:0050892]; intracellular chloride ion homeostasis [GO:0030644]; iodide transport [GO:0015705]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; negative regulation of gene expression [GO:0010629]; negative regulation of voltage-gated potassium channel activity [GO:1903817]; non-motile cilium assembly [GO:1905515]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of heart rate [GO:0010460]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export across plasma membrane [GO:0097623]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of blood pressure [GO:0008217]; regulation of gastric acid secretion [GO:0060453]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of heart contraction [GO:0008016]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; renal absorption [GO:0070293]; renal sodium ion absorption [GO:0070294]; response to insulin [GO:0032868]; response to nicotine [GO:0035094]; rhythmic behavior [GO:0007622]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; stomach development [GO:0062094]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:18165683, ECO:0000269|PubMed:21228319, ECO:0000269|PubMed:22024150, ECO:0000269|PubMed:25037568}; Multi-pass membrane protein {ECO:0000269|PubMed:18165683}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18165683, ECO:0000269|PubMed:23529131}. Early endosome {ECO:0000269|PubMed:23529131}. Membrane raft {ECO:0000269|PubMed:20533308, ECO:0000269|PubMed:24855057}. Endoplasmic reticulum {ECO:0000269|PubMed:21228319, ECO:0000269|PubMed:24855057}. Basolateral cell membrane {ECO:0000269|PubMed:21228319}. Apical cell membrane {ECO:0000250|UniProtKB:P97414}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with KCNE3 at the plasma membrane (PubMed:10646604). Upon 17beta-oestradiol treatment, colocalizes with RAB5A at early endosome (PubMed:23529131). Heterotetramer with KCNQ5 is highly retained at the endoplasmic reticulum and is localized outside of lipid raft microdomains (PubMed:24855057). During the early stages of epithelial cell polarization induced by the calcium switch, it is removed from the plasma membrane to the endoplasmic reticulum, where it is retained, and redistributed to the basolateral cell surface in a PI3K-dependent manner at a later stage (PubMed:21228319). Colocalizes with SLC5A3 at the apical membrane of choroid plexus epithelium. {ECO:0000250|UniProtKB:P97414, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:21228319, ECO:0000269|PubMed:23529131, ECO:0000269|PubMed:24855057}.
P51788	reviewed	CLCN2_HUMAN	Chloride channel protein 2 (ClC-2)	CLCN2	Homo sapiens (Human)	898	FUNCTION: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012). {ECO:0000269|PubMed:19153159, ECO:0000269|PubMed:19191339, ECO:0000269|PubMed:29403011, ECO:0000269|PubMed:29403012}.	MISCELLANEOUS: The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (By similarity). {ECO:0000250}.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	acinar cell differentiation [GO:0090425]; cell differentiation involved in salivary gland development [GO:0060689]; chloride transport [GO:0006821]; lung development [GO:0030324]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of aldosterone biosynthetic process [GO:0032347]; regulation of monoatomic ion transmembrane transport [GO:0034765]; retina development in camera-type eye [GO:0060041]	chloride channel complex [GO:0034707]; dendrite [GO:0030425]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]	voltage-gated chloride channel activity [GO:0005247]	chloride channel complex [GO:0034707]; dendrite [GO:0030425]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; voltage-gated chloride channel activity [GO:0005247]; acinar cell differentiation [GO:0090425]; cell differentiation involved in salivary gland development [GO:0060689]; chloride transport [GO:0006821]; lung development [GO:0030324]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of aldosterone biosynthetic process [GO:0032347]; regulation of monoatomic ion transmembrane transport [GO:0034765]; retina development in camera-type eye [GO:0060041]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29403011, ECO:0000269|PubMed:36964785}; Multi-pass membrane protein.
P51790	reviewed	CLCN3_HUMAN	H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3)	CLCN3	Homo sapiens (Human)	818	FUNCTION: [Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874). {ECO:0000250|UniProtKB:P51791, ECO:0000303|PubMed:29845874}.; FUNCTION: [Isoform 2]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. {ECO:0000269|PubMed:11967229}.		adult locomotory behavior [GO:0008344]; chloride transmembrane transport [GO:1902476]; endosomal lumen acidification [GO:0048388]; negative regulation of cell volume [GO:0045794]; phagocytosis, engulfment [GO:0006911]; photoreceptor cell maintenance [GO:0045494]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; regulation of pH [GO:0006885]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle lumen acidification [GO:0097401]	axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; ruffle membrane [GO:0032587]; secretory granule [GO:0030141]; specific granule [GO:0042581]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle membrane [GO:0012506]	antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride channel activity [GO:0005254]; PDZ domain binding [GO:0030165]; voltage-gated chloride channel activity [GO:0005247]; volume-sensitive chloride channel activity [GO:0072320]	axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; ruffle membrane [GO:0032587]; secretory granule [GO:0030141]; specific granule [GO:0042581]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle membrane [GO:0012506]; antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride channel activity [GO:0005254]; PDZ domain binding [GO:0030165]; voltage-gated chloride channel activity [GO:0005247]; volume-sensitive chloride channel activity [GO:0072320]; adult locomotory behavior [GO:0008344]; chloride transmembrane transport [GO:1902476]; endosomal lumen acidification [GO:0048388]; negative regulation of cell volume [GO:0045794]; phagocytosis, engulfment [GO:0006911]; photoreceptor cell maintenance [GO:0045494]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; regulation of pH [GO:0006885]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle lumen acidification [GO:0097401]	SUBCELLULAR LOCATION: [Isoform 1]: Early endosome membrane {ECO:0000269|PubMed:12471024}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:12471024}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:P51791}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P51792}; Multi-pass membrane protein {ECO:0000255}. Note=Isoform 1 is localized mainly in late endosomes. {ECO:0000269|PubMed:12471024}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane {ECO:0000269|PubMed:12471024}; Multi-pass membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:11967229}; Multi-pass membrane protein {ECO:0000269|PubMed:11967229}. Note=Isoform 2 is mainly enriched in the Golgi (PubMed:12471024). Colocalizes with NHERF1/EBP50 in membrane ruffles (PubMed:11967229). {ECO:0000269|PubMed:11967229, ECO:0000269|PubMed:12471024}.
P51793	reviewed	CLCN4_HUMAN	H(+)/Cl(-) exchange transporter 4 (Chloride channel protein 4) (ClC-4) (Chloride transporter ClC-4)	CLCN4	Homo sapiens (Human)	760	FUNCTION: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:18063579, PubMed:28972156, PubMed:23647072, PubMed:27550844, PubMed:25644381). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874). {ECO:0000269|PubMed:18063579, ECO:0000269|PubMed:23647072, ECO:0000269|PubMed:25644381, ECO:0000269|PubMed:27550844, ECO:0000269|PubMed:28972156, ECO:0000303|PubMed:29845874}.		chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]; non-motile cilium assembly [GO:1905515]	ciliary base [GO:0097546]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]	antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride channel activity [GO:0005254]; voltage-gated chloride channel activity [GO:0005247]	ciliary base [GO:0097546]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride channel activity [GO:0005254]; voltage-gated chloride channel activity [GO:0005247]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]; non-motile cilium assembly [GO:1905515]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:P51794}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17023393, ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to late endosome membrane, lysosome membrane and recycling endosome membrane in the presence of CLCN3. {ECO:0000269|PubMed:28972156}.
P51795	reviewed	CLCN5_HUMAN	H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)	CLCN5 CLCK2	Homo sapiens (Human)	816	FUNCTION: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (PubMed:20466723). Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). {ECO:0000269|PubMed:20466723, ECO:0000305}.		chloride transport [GO:0006821]; endocytosis [GO:0006897]; monoatomic ion transmembrane transport [GO:0034220]; renal system process [GO:0003014]	apical part of cell [GO:0045177]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	antiporter activity [GO:0015297]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; voltage-gated chloride channel activity [GO:0005247]	apical part of cell [GO:0045177]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; antiporter activity [GO:0015297]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; voltage-gated chloride channel activity [GO:0005247]; chloride transport [GO:0006821]; endocytosis [GO:0006897]; monoatomic ion transmembrane transport [GO:0034220]; renal system process [GO:0003014]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. Endosome membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. Cell membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}.
P51797	reviewed	CLCN6_HUMAN	H(+)/Cl(-) exchange transporter 6 (Chloride channel protein 6) (ClC-6) (Chloride transport protein 6)	CLCN6 KIAA0046	Homo sapiens (Human)	869	FUNCTION: Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. {ECO:0000269|PubMed:20466723}.		cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]; response to mechanical stimulus [GO:0009612]; signal transduction [GO:0007165]	endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]	antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride transmembrane transporter activity [GO:0015108]; voltage-gated chloride channel activity [GO:0005247]	endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride transmembrane transporter activity [GO:0015108]; voltage-gated chloride channel activity [GO:0005247]; cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]; response to mechanical stimulus [GO:0009612]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:17534424, ECO:0000269|PubMed:33217309}; Multi-pass membrane protein {ECO:0000269|PubMed:17534424}.
P51798	reviewed	CLCN7_HUMAN	H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7)	CLCN7	Homo sapiens (Human)	805	FUNCTION: Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}.		transepithelial chloride transport [GO:0030321]	chloride channel complex [GO:0034707]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]	antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; voltage-gated chloride channel activity [GO:0005247]	chloride channel complex [GO:0034707]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; voltage-gated chloride channel activity [GO:0005247]; transepithelial chloride transport [GO:0030321]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911}.
P51800	reviewed	CLCKA_HUMAN	Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1)	CLCNKA	Homo sapiens (Human)	687	FUNCTION: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.		chloride transport [GO:0006821]; regulation of monoatomic ion transmembrane transport [GO:0034765]; renal absorption [GO:0070293]; transepithelial chloride transport [GO:0030321]	chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; voltage-gated chloride channel activity [GO:0005247]	chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; voltage-gated chloride channel activity [GO:0005247]; chloride transport [GO:0006821]; regulation of monoatomic ion transmembrane transport [GO:0034765]; renal absorption [GO:0070293]; transepithelial chloride transport [GO:0030321]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P51801	reviewed	CLCKB_HUMAN	Chloride channel protein ClC-Kb (Chloride channel Kb) (ClC-K2)	CLCNKB	Homo sapiens (Human)	687	FUNCTION: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. {ECO:0000269|PubMed:11734858}.	MISCELLANEOUS: Compared with CLCNKA/BSND, CLCNKB/BSND is more sensitive to pH and less responsive to Ca(2+).	chloride transport [GO:0006821]; regulation of monoatomic ion transmembrane transport [GO:0034765]; renal absorption [GO:0070293]; renal sodium ion absorption [GO:0070294]; transepithelial chloride transport [GO:0030321]	chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; voltage-gated chloride channel activity [GO:0005247]	chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; voltage-gated chloride channel activity [GO:0005247]; chloride transport [GO:0006821]; regulation of monoatomic ion transmembrane transport [GO:0034765]; renal absorption [GO:0070293]; renal sodium ion absorption [GO:0070294]; transepithelial chloride transport [GO:0030321]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P51805	reviewed	PLXA3_HUMAN	Plexin-A3 (Plexin-4) (Semaphorin receptor SEX)	PLXNA3 PLXN4 SEX	Homo sapiens (Human)	1871	FUNCTION: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.		axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; facial nerve structural organization [GO:0021612]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; hippocampus development [GO:0021766]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; neuron projection guidance [GO:0097485]; olfactory nerve formation [GO:0021628]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cytoskeleton organization [GO:0051495]; pyramidal neuron development [GO:0021860]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; trigeminal nerve structural organization [GO:0021637]	plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	semaphorin receptor activity [GO:0017154]	plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]; semaphorin receptor activity [GO:0017154]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; facial nerve structural organization [GO:0021612]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; hippocampus development [GO:0021766]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; neuron projection guidance [GO:0097485]; olfactory nerve formation [GO:0021628]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cytoskeleton organization [GO:0051495]; pyramidal neuron development [GO:0021860]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; trigeminal nerve structural organization [GO:0021637]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
P51808	reviewed	DYLT3_HUMAN	Dynein light chain Tctex-type 3 (Protein 91/23) (T-complex-associated testis-expressed 1-like)	DYNLT3 TCTE1L TCTE1XL	Homo sapiens (Human)	116	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity). {ECO:0000250}.		cell cycle [GO:0007049]; cell division [GO:0051301]; microtubule-based movement [GO:0007018]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of mitotic cell cycle [GO:0007346]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; kinetochore [GO:0000776]; mitotic spindle astral microtubule [GO:0061673]; nucleus [GO:0005634]	dynein intermediate chain binding [GO:0045505]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; kinetochore [GO:0000776]; mitotic spindle astral microtubule [GO:0061673]; nucleus [GO:0005634]; dynein intermediate chain binding [GO:0045505]; identical protein binding [GO:0042802]; cell cycle [GO:0007049]; cell division [GO:0051301]; microtubule-based movement [GO:0007018]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Note=Colocalizes with BUB3 at kinetochores specifically during prometaphase.
P51809	reviewed	VAMP7_HUMAN	Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1) (Tetanus-insensitive VAMP) (Ti-VAMP)	VAMP7 SYBL1	Homo sapiens (Human)	220	FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. {ECO:0000269|PubMed:10888671, ECO:0000269|PubMed:16677249, ECO:0000269|PubMed:18042464}.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.; MISCELLANEOUS: Loss-of-function mutant (antisense inhibition) displays impaired granzyme B release and target cell killing by natural killer cells.	calcium-ion regulated exocytosis [GO:0017156]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endosome to lysosome transport [GO:0008333]; eosinophil degranulation [GO:0043308]; exocytosis [GO:0006887]; natural killer cell degranulation [GO:0043320]; neutrophil degranulation [GO:0043312]; phagocytosis, engulfment [GO:0006911]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]	azurophil granule membrane [GO:0035577]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; neuron projection [GO:0043005]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; pseudopodium [GO:0031143]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; SNARE complex [GO:0031201]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; transport vesicle membrane [GO:0030658]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	azurophil granule membrane [GO:0035577]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; neuron projection [GO:0043005]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; pseudopodium [GO:0031143]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; SNARE complex [GO:0031201]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; transport vesicle membrane [GO:0030658]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; calcium-ion regulated exocytosis [GO:0017156]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endosome to lysosome transport [GO:0008333]; eosinophil degranulation [GO:0043308]; exocytosis [GO:0006887]; natural killer cell degranulation [GO:0043320]; neutrophil degranulation [GO:0043312]; phagocytosis, engulfment [GO:0006911]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Single-pass type IV membrane protein {ECO:0000269|PubMed:17897319}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity). {ECO:0000250}.
P51810	reviewed	GP143_HUMAN	G-protein coupled receptor 143 (Ocular albinism type 1 protein)	GPR143 OA1	Homo sapiens (Human)	404	FUNCTION: Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. {ECO:0000269|PubMed:10471510, ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:18697795, ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:19717472}.		calcium-mediated signaling using intracellular calcium source [GO:0035584]; eye pigment biosynthetic process [GO:0006726]; G protein-coupled receptor signaling pathway [GO:0007186]; melanosome localization [GO:0032400]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of calcium-mediated signaling [GO:0050848]; regulation of melanosome organization [GO:1903056]; regulation of melanosome transport [GO:1902908]; signal transduction [GO:0007165]; visual perception [GO:0007601]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886]	dopamine binding [GO:0035240]; G protein-coupled receptor activity [GO:0004930]; L-DOPA binding [GO:0072544]; L-DOPA receptor activity [GO:0035643]; tyrosine binding [GO:0072545]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886]; dopamine binding [GO:0035240]; G protein-coupled receptor activity [GO:0004930]; L-DOPA binding [GO:0072544]; L-DOPA receptor activity [GO:0035643]; tyrosine binding [GO:0072545]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; eye pigment biosynthetic process [GO:0006726]; G protein-coupled receptor signaling pathway [GO:0007186]; melanosome localization [GO:0032400]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of calcium-mediated signaling [GO:0050848]; regulation of melanosome organization [GO:1903056]; regulation of melanosome transport [GO:1902908]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:10471510, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:16621890, ECO:0000269|PubMed:17081065}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:16621890}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:18828673}; Multi-pass membrane protein {ECO:0000255}. Note=Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine (PubMed:18828673). {ECO:0000269|PubMed:18828673}.
P51811	reviewed	XK_HUMAN	Endoplasmic reticulum membrane adapter protein XK (Kell complex 37 kDa component) (Kx antigen) (Membrane transport protein XK) (XK-related protein 1)	XK XKR1 XRG1	Homo sapiens (Human)	444	FUNCTION: Recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane. {ECO:0000269|PubMed:32845802}.		amino acid transport [GO:0006865]; intracellular calcium ion homeostasis [GO:0006874]; intracellular magnesium ion homeostasis [GO:0010961]; myelination [GO:0042552]; regulation of axon diameter [GO:0031133]; regulation of cell size [GO:0008361]; skeletal muscle fiber development [GO:0048741]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	protein-macromolecule adaptor activity [GO:0030674]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-macromolecule adaptor activity [GO:0030674]; amino acid transport [GO:0006865]; intracellular calcium ion homeostasis [GO:0006874]; intracellular magnesium ion homeostasis [GO:0010961]; myelination [GO:0042552]; regulation of axon diameter [GO:0031133]; regulation of cell size [GO:0008361]; skeletal muscle fiber development [GO:0048741]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:32845802, ECO:0000269|PubMed:9593744}; Multi-pass membrane protein {ECO:0000255}.
P51812	reviewed	KS6A3_HUMAN	Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)	RPS6KA3 ISPK1 MAPKAPK1B RSK2	Homo sapiens (Human)	740	FUNCTION: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:9770464, PubMed:16223362, PubMed:17360704, PubMed:16213824). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:9770464, PubMed:10436156). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.		cell cycle [GO:0007049]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell growth [GO:0030307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of translation in response to stress [GO:0043555]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; toll-like receptor signaling pathway [GO:0002224]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; synapse [GO:0045202]	ATP binding [GO:0005524]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosomal protein S6 kinase activity [GO:0004711]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; synapse [GO:0045202]; ATP binding [GO:0005524]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosomal protein S6 kinase activity [GO:0004711]; cell cycle [GO:0007049]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell growth [GO:0030307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of translation in response to stress [GO:0043555]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; toll-like receptor signaling pathway [GO:0002224]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17213202}. Cytoplasm {ECO:0000269|PubMed:17213202}.
P51813	reviewed	BMX_HUMAN	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)	BMX	Homo sapiens (Human)	675	FUNCTION: Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}.		adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; cell adhesion [GO:0007155]; intracellular signal transduction [GO:0035556]; mesoderm development [GO:0007498]; phosphatidylinositol biosynthetic process [GO:0006661]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; cell adhesion [GO:0007155]; intracellular signal transduction [GO:0035556]; mesoderm development [GO:0007498]; phosphatidylinositol biosynthetic process [GO:0006661]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Localizes to the edges of spreading cells when complexed with BCAR1.
P51814	reviewed	ZNF41_HUMAN	Zinc finger protein 41	ZNF41	Homo sapiens (Human)	821	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P51816	reviewed	AFF2_HUMAN	AF4/FMR2 family member 2 (Protein FMR-2) (FMR2P) (Protein Ox19)	AFF2 FMR2 OX19	Homo sapiens (Human)	1311	FUNCTION: RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. {ECO:0000269|PubMed:19136466}.		brain development [GO:0007420]; learning or memory [GO:0007611]; mRNA processing [GO:0006397]; negative regulation of gene expression [GO:0010629]; nuclear speck organization [GO:0035063]; regulation of gene expression [GO:0010468]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]	G-quadruplex RNA binding [GO:0002151]	nuclear speck [GO:0016607]; G-quadruplex RNA binding [GO:0002151]; brain development [GO:0007420]; learning or memory [GO:0007611]; mRNA processing [GO:0006397]; negative regulation of gene expression [GO:0010629]; nuclear speck organization [GO:0035063]; regulation of gene expression [GO:0010468]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:19136466}. Note=When splicing is inhibited, accumulates in enlarged speckles.
P51817	reviewed	PRKX_HUMAN	cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1)	PRKX PKX1	Homo sapiens (Human)	358	FUNCTION: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269|PubMed:12082174, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:17980165, ECO:0000269|PubMed:19367327, ECO:0000269|PubMed:21684272, ECO:0000269|PubMed:9860982}.		angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial tube morphogenesis [GO:0060562]; kidney morphogenesis [GO:0060993]; myeloid cell differentiation [GO:0030099]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of epithelial cell differentiation involved in kidney development [GO:2000696]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; protein serine kinase activity [GO:0106310]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial tube morphogenesis [GO:0060562]; kidney morphogenesis [GO:0060993]; myeloid cell differentiation [GO:0030099]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of epithelial cell differentiation involved in kidney development [GO:2000696]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.
P51825	reviewed	AFF1_HUMAN	AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)	AFF1 AF4 FEL MLLT2 PBM1	Homo sapiens (Human)	1210			regulation of gene expression [GO:0010468]	super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023]		super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P51826	reviewed	AFF3_HUMAN	AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4)	AFF3 LAF4	Homo sapiens (Human)	1226	FUNCTION: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.		embryonic hindlimb morphogenesis [GO:0035116]; regulation of gene expression [GO:0010468]; response to tumor necrosis factor [GO:0034612]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; super elongation complex [GO:0032783]	DNA-binding transcription factor activity [GO:0003700]; double-stranded DNA binding [GO:0003690]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; super elongation complex [GO:0032783]; DNA-binding transcription factor activity [GO:0003700]; double-stranded DNA binding [GO:0003690]; embryonic hindlimb morphogenesis [GO:0035116]; regulation of gene expression [GO:0010468]; response to tumor necrosis factor [GO:0034612]	SUBCELLULAR LOCATION: Nucleus.
P51828	reviewed	ADCY7_HUMAN	Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7)	ADCY7 KIAA0037	Homo sapiens (Human)	1080	FUNCTION: Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity). {ECO:0000250|UniProtKB:P51829, ECO:0000269|PubMed:18541530, ECO:0000269|PubMed:23229509, ECO:0000269|PubMed:23842570, ECO:0000305|PubMed:18541530, ECO:0000305|PubMed:23229509}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cAMP biosynthetic process [GO:0006171]; cellular response to ethanol [GO:0071361]; cellular response to lithium ion [GO:0071285]; intracellular signal transduction [GO:0035556]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; regulation of adaptive immune response [GO:0002819]	membrane [GO:0016020]; plasma membrane [GO:0005886]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]	membrane [GO:0016020]; plasma membrane [GO:0005886]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cAMP biosynthetic process [GO:0006171]; cellular response to ethanol [GO:0071361]; cellular response to lithium ion [GO:0071285]; intracellular signal transduction [GO:0035556]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; regulation of adaptive immune response [GO:0002819]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P51841	reviewed	GUC2F_HUMAN	Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2)	GUCY2F GUC2F RETGC2	Homo sapiens (Human)	1108	FUNCTION: Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:7777544). Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). {ECO:0000250|UniProtKB:Q5SDA5, ECO:0000269|PubMed:7777544}.		cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; detection of light stimulus involved in visual perception [GO:0050908]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; visual perception [GO:0007601]	nuclear outer membrane [GO:0005640]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; identical protein binding [GO:0042802]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]	nuclear outer membrane [GO:0005640]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; identical protein binding [GO:0042802]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; detection of light stimulus involved in visual perception [GO:0050908]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:O02740}; Single-pass type I membrane protein {ECO:0000255}.
P51843	reviewed	NR0B1_HUMAN	Nuclear receptor subfamily 0 group B member 1 (DSS-AHC critical region on the X chromosome protein 1) (Nuclear receptor DAX-1)	NR0B1 AHC DAX1	Homo sapiens (Human)	470	FUNCTION: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: More abundant than isoform 1 in all tissues tested except testis where they are nearly equal. {ECO:0000305}.	adrenal gland development [GO:0030325]; endodermal cell differentiation [GO:0035987]; gonad development [GO:0008406]; hypothalamus development [GO:0021854]; Leydig cell differentiation [GO:0033327]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pituitary gland development [GO:0021983]; protein localization [GO:0008104]; response to immobilization stress [GO:0035902]; Sertoli cell differentiation [GO:0060008]; spermatogenesis [GO:0007283]	centriolar satellite [GO:0034451]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]	AF-2 domain binding [GO:0050682]; DNA hairpin binding [GO:0032448]; nuclear receptor binding [GO:0016922]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]	centriolar satellite [GO:0034451]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; AF-2 domain binding [GO:0050682]; DNA hairpin binding [GO:0032448]; nuclear receptor binding [GO:0016922]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; adrenal gland development [GO:0030325]; endodermal cell differentiation [GO:0035987]; gonad development [GO:0008406]; hypothalamus development [GO:0021854]; Leydig cell differentiation [GO:0033327]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pituitary gland development [GO:0021983]; protein localization [GO:0008104]; response to immobilization stress [GO:0035902]; Sertoli cell differentiation [GO:0060008]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16709599}. Cytoplasm {ECO:0000269|PubMed:16709599}. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus.
P51854	reviewed	TKTL1_HUMAN	Transketolase-like protein 1 (EC 2.2.1.1) (Transketolase 2) (TK 2) (Transketolase-related protein)	TKTL1 TKR TKT2	Homo sapiens (Human)	596	FUNCTION: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000250|UniProtKB:P23254}.; FUNCTION: [Isoform 4]: During fetal neocortex development, may be essential to maintain the full number of basal radial glia (bRG). bRG are neural progenitor cells that undergo asymmetric divisions, generating a bRG (self-renewal) and a neuron, in contrast to basal intermediate progenitors (bIPs), which typically divide once to give rise to 2 neurons. bRG generate more cortical neurons over time than bIPs. {ECO:0000269|PubMed:36074851}.		glucose catabolic process [GO:0006007]; thiamine metabolic process [GO:0006772]	cytosol [GO:0005829]	metal ion binding [GO:0046872]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802]	cytosol [GO:0005829]; metal ion binding [GO:0046872]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802]; glucose catabolic process [GO:0006007]; thiamine metabolic process [GO:0006772]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:15991799}.
P51857	reviewed	AK1D1_HUMAN	Aldo-keto reductase family 1 member D1 (EC 1.3.1.3) (3-oxo-5-beta-steroid 4-dehydrogenase) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase)	AKR1D1 SRD5B1	Homo sapiens (Human)	326	FUNCTION: Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one). {ECO:0000269|PubMed:11342103, ECO:0000269|PubMed:18407998, ECO:0000269|PubMed:20522910, ECO:0000269|PubMed:21255593, ECO:0000269|PubMed:7508385}.		androgen metabolic process [GO:0008209]; bile acid biosynthetic process [GO:0006699]; bile acid catabolic process [GO:0030573]; C21-steroid hormone metabolic process [GO:0008207]; cholesterol catabolic process [GO:0006707]; digestion [GO:0007586]	cytosol [GO:0005829]	alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; delta4-3-oxosteroid 5beta-reductase activity [GO:0047787]; ketosteroid monooxygenase activity [GO:0047086]; steroid binding [GO:0005496]; steroid dehydrogenase activity [GO:0016229]	cytosol [GO:0005829]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; delta4-3-oxosteroid 5beta-reductase activity [GO:0047787]; ketosteroid monooxygenase activity [GO:0047086]; steroid binding [GO:0005496]; steroid dehydrogenase activity [GO:0016229]; androgen metabolic process [GO:0008209]; bile acid biosynthetic process [GO:0006699]; bile acid catabolic process [GO:0030573]; C21-steroid hormone metabolic process [GO:0008207]; cholesterol catabolic process [GO:0006707]; digestion [GO:0007586]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7508385}.
P51858	reviewed	HDGF_HUMAN	Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2)	HDGF HMG1L2	Homo sapiens (Human)	240	FUNCTION: [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}.		chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell division [GO:0051781]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; signal transduction [GO:0007165]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	actin binding [GO:0003779]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; tubulin binding [GO:0015631]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; actin binding [GO:0003779]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; tubulin binding [GO:0015631]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell division [GO:0051781]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:26845719}. Cytoplasm {ECO:0000269|PubMed:11751870}. Secreted, extracellular exosome {ECO:0000269|PubMed:27926477}. Note=Secreted by exosomes and is located inside the exosome (PubMed:27926477). May also be secreted as free protein via an as yet unknown pathway (PubMed:27926477). {ECO:0000269|PubMed:27926477}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:26845719}. Cytoplasm {ECO:0000269|PubMed:26845719}. Secreted, extracellular exosome {ECO:0000269|PubMed:27926477}. Note=Secreted by exosomes and is located on the outer exosome surface. {ECO:0000269|PubMed:27926477}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:26845719}. Cytoplasm {ECO:0000269|PubMed:26845719}. Secreted, extracellular exosome {ECO:0000269|PubMed:27926477}. Note=Secreted by exosomes and is located on the outer exosome surface. {ECO:0000269|PubMed:27926477}.
P51864	reviewed	TDGF3_HUMAN	Putative protein CRIPTO3 (Cripto, EGF-CFC family member 3) (Cripto-3 growth factor) (Epidermal growth factor-like cripto protein CR3) (Teratocarcinoma-derived growth factor 1 pseudogene 3) (Teratocarcinoma-derived growth factor 3)	CRIPTO3 CRIPTO-3 TDGF1P3 TDGF2 TDGF3	Homo sapiens (Human)	188	FUNCTION: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Activates the Nodal-dependent signaling pathway. {ECO:0000269|PubMed:18835250}.		anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; nodal signaling pathway [GO:0038092]; signal transduction [GO:0007165]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	activin receptor binding [GO:0070697]; growth factor activity [GO:0008083]; nodal binding [GO:0038100]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; activin receptor binding [GO:0070697]; growth factor activity [GO:0008083]; nodal binding [GO:0038100]; anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; nodal signaling pathway [GO:0038092]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18835250}.
P51878	reviewed	CASP5_HUMAN	Caspase-5 (CASP-5) (EC 3.4.22.58) (ICE(rel)-III) (Protease ICH-3) (Protease TY) [Cleaved into: Caspase-5 subunit p20; Caspase-5 subunit p10]	CASP5 ICH3	Homo sapiens (Human)	434	FUNCTION: Thiol protease that acts as a mediator of programmed cell death (PubMed:29898893, PubMed:28314590). Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (PubMed:29898893). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). {ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:29898893}.	MISCELLANEOUS: [Isoform 1]: Most abundant isoform.; MISCELLANEOUS: [Isoform 2]: Most abundant isoform. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative initiation at Met-71 of isoform 1. {ECO:0000305}.	apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; substantia nigra development [GO:0021762]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP1 inflammasome complex [GO:0072558]	cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; cysteine-type peptidase activity [GO:0008234]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP1 inflammasome complex [GO:0072558]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; cysteine-type peptidase activity [GO:0008234]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; substantia nigra development [GO:0021762]	
P51884	reviewed	LUM_HUMAN	Lumican (Keratan sulfate proteoglycan lumican) (KSPG lumican)	LUM LDC SLRR2D	Homo sapiens (Human)	338			collagen fibril organization [GO:0030199]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914]; visual perception [GO:0007601]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrillar collagen trimer [GO:0005583]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]	collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrillar collagen trimer [GO:0005583]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; collagen fibril organization [GO:0030199]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
P51888	reviewed	PRELP_HUMAN	Prolargin (Proline-arginine-rich end leucine-rich repeat protein)	PRELP SLRR2A	Homo sapiens (Human)	382	FUNCTION: May anchor basement membranes to the underlying connective tissue. {ECO:0000250|UniProtKB:Q9GKN8}.		cellular senescence [GO:0090398]; skeletal system development [GO:0001501]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]	extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; heparin binding [GO:0008201]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; heparin binding [GO:0008201]; cellular senescence [GO:0090398]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
P51946	reviewed	CCNH_HUMAN	Cyclin-H (MO15-associated protein) (p34) (p37)	CCNH	Homo sapiens (Human)	323	FUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:7533895}.		cell cycle [GO:0007049]; protein stabilization [GO:0050821]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	CAK-ERCC2 complex [GO:0070516]; cyclin-dependent protein kinase activating kinase holoenzyme complex [GO:0019907]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription factor TFIIK complex [GO:0070985]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	CAK-ERCC2 complex [GO:0070516]; cyclin-dependent protein kinase activating kinase holoenzyme complex [GO:0019907]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription factor TFIIK complex [GO:0070985]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; cell cycle [GO:0007049]; protein stabilization [GO:0050821]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus.
P51948	reviewed	MAT1_HUMAN	CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36)	MNAT1 CAP35 MAT1 RNF66	Homo sapiens (Human)	309	FUNCTION: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}.		adult heart development [GO:0007512]; DNA repair [GO:0006281]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA helicase activity [GO:1905775]; nucleotide-excision repair [GO:0006289]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein-containing complex assembly [GO:0065003]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; response to calcium ion [GO:0051592]; transcription by RNA polymerase II [GO:0006366]; ventricular system development [GO:0021591]	CAK-ERCC2 complex [GO:0070516]; cyclin-dependent protein kinase activating kinase holoenzyme complex [GO:0019907]; nucleoplasm [GO:0005654]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription factor TFIIK complex [GO:0070985]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; zinc ion binding [GO:0008270]	CAK-ERCC2 complex [GO:0070516]; cyclin-dependent protein kinase activating kinase holoenzyme complex [GO:0019907]; nucleoplasm [GO:0005654]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription factor TFIIK complex [GO:0070985]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; zinc ion binding [GO:0008270]; adult heart development [GO:0007512]; DNA repair [GO:0006281]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA helicase activity [GO:1905775]; nucleotide-excision repair [GO:0006289]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein-containing complex assembly [GO:0065003]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; response to calcium ion [GO:0051592]; transcription by RNA polymerase II [GO:0006366]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: Nucleus.
P51955	reviewed	NEK2_HUMAN	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1)	NEK2 NEK2A NLK1	Homo sapiens (Human)	445	FUNCTION: Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.		blastocyst development [GO:0001824]; cell division [GO:0051301]; centrosome separation [GO:0051299]; chromosome segregation [GO:0007059]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; negative regulation of centriole-centriole cohesion [GO:1903126]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of mitotic centrosome separation [GO:0046602]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; blastocyst development [GO:0001824]; cell division [GO:0051301]; centrosome separation [GO:0051299]; chromosome segregation [GO:0007059]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; negative regulation of centriole-centriole cohesion [GO:1903126]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of mitotic centrosome separation [GO:0046602]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Nucleus, nucleolus {ECO:0000269|PubMed:15161910}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:26220856}. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Chromosome, centromere {ECO:0000250}. Note=STK3/MST2 and SAV1 are required for its targeting to the centrosome. Colocalizes with SGO1 and MAD1L1 at the kinetochore. Not associated with kinetochore in the interphase but becomes associated with it upon the breakdown of the nuclear envelope. Has a nucleolar targeting/ retention activity via a coiled-coil domain at the C-terminal end.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Predominantly cytoplasmic.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly nuclear.
P51956	reviewed	NEK3_HUMAN	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3)	NEK3	Homo sapiens (Human)	506	FUNCTION: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. {ECO:0000269|PubMed:15618286, ECO:0000269|PubMed:17297458}.		cell division [GO:0051301]; establishment of cell polarity [GO:0030010]; mitotic cell cycle [GO:0000278]; neuron projection morphogenesis [GO:0048812]; protein phosphorylation [GO:0006468]; regulation of tubulin deacetylation [GO:0090043]	axon [GO:0030424]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	axon [GO:0030424]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell division [GO:0051301]; establishment of cell polarity [GO:0030010]; mitotic cell cycle [GO:0000278]; neuron projection morphogenesis [GO:0048812]; protein phosphorylation [GO:0006468]; regulation of tubulin deacetylation [GO:0090043]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000250}.
P51957	reviewed	NEK4_HUMAN	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)	NEK4 STK2	Homo sapiens (Human)	841	FUNCTION: Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}.		cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic cell cycle [GO:0000278]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]	ciliary basal body [GO:0036064]; ciliary plasm [GO:0097014]; ciliary rootlet [GO:0035253]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ciliary basal body [GO:0036064]; ciliary plasm [GO:0097014]; ciliary rootlet [GO:0035253]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic cell cycle [GO:0000278]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:21685204}. Cytoplasm {ECO:0000269|PubMed:21685204}.
P51959	reviewed	CCNG1_HUMAN	Cyclin-G1 (Cyclin-G)	CCNG1 CCNG CYCG1	Homo sapiens (Human)	295	FUNCTION: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). {ECO:0000250}.		cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; response to gravity [GO:0009629]; response to organonitrogen compound [GO:0010243]; syncytium formation [GO:0006949]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; response to gravity [GO:0009629]; response to organonitrogen compound [GO:0010243]; syncytium formation [GO:0006949]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10196184}. Note=DNA replication foci after DNA damage.
P51965	reviewed	UB2E1_HUMAN	Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1)	UBE2E1 UBCH6	Homo sapiens (Human)	193	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. {ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:20061386}.		ISG15-protein conjugation [GO:0032020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	ATP binding [GO:0005524]; ISG15 transferase activity [GO:0042296]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ISG15 transferase activity [GO:0042296]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; ISG15-protein conjugation [GO:0032020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18845142}.
P51970	reviewed	NDUA8_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit)	NDUFA8	Homo sapiens (Human)	172	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371, PubMed:32385911, PubMed:33153867). Complex I functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). {ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:32385911, ECO:0000269|PubMed:33153867}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]; protein-containing complex binding [GO:0044877]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; protein-containing complex binding [GO:0044877]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21310150}; Peripheral membrane protein {ECO:0000269|PubMed:21310150}. Mitochondrion intermembrane space {ECO:0000269|PubMed:21310150}. Mitochondrion {ECO:0000269|PubMed:23676665}.
P51991	reviewed	ROA3_HUMAN	Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)	HNRNPA3 HNRPA3	Homo sapiens (Human)	378	FUNCTION: Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:11886857}.		mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Component of ribonucleosomes.
P51993	reviewed	FUT6_HUMAN	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (EC 2.4.1.152) (Fucosyltransferase 6) (Fucosyltransferase VI) (Fuc-TVI) (FucT-VI) (Galactoside 3-L-fucosyltransferase)	FUT6 FCT3A	Homo sapiens (Human)	359	FUNCTION: [Isoform 1]: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or a glycolipid-linked polylactosamines chain through an alpha-1,3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe(x)), Lewis X (Le(x)) and non sialylated VIM2 determinants (PubMed:9451035, PubMed:1520296, PubMed:1339443, PubMed:7650030, PubMed:17604274, PubMed:9363434, PubMed:10728707, PubMed:29593094). Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates in difucosylated sialyl Lewis x determinants (PubMed:17604274, PubMed:1339443). Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X (PubMed:10728707). Does not have activity towards type 1 ((Galbeta1-3GlcNAc)) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates (PubMed:1339443, PubMed:17604274, PubMed:9363434). {ECO:0000269|PubMed:10728707, ECO:0000269|PubMed:1339443, ECO:0000269|PubMed:1520296, ECO:0000269|PubMed:17604274, ECO:0000269|PubMed:7650030, ECO:0000269|PubMed:9363434, ECO:0000269|PubMed:9451035}.; FUNCTION: [Isoform 2]: Does not have alpha(1,3)-fucosyltransferase activity. {ECO:0000269|PubMed:7650030}.		ceramide metabolic process [GO:0006672]; glycosphingolipid biosynthetic process [GO:0006688]; L-fucose catabolic process [GO:0042355]; N-glycan fucosylation [GO:0036071]; oligosaccharide biosynthetic process [GO:0009312]; oocyte axis specification [GO:0007309]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; methylosome [GO:0034709]	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; methylosome [GO:0034709]; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]; ceramide metabolic process [GO:0006672]; glycosphingolipid biosynthetic process [GO:0006688]; L-fucose catabolic process [GO:0042355]; N-glycan fucosylation [GO:0036071]; oligosaccharide biosynthetic process [GO:0009312]; oocyte axis specification [GO:0007309]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Golgi apparatus {ECO:0000269|PubMed:9451035}. Secreted {ECO:0000269|PubMed:9451035}. Note=Membrane-bound form in trans cisternae of Golgi.
P52179	reviewed	MYOM1_HUMAN	Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1)	MYOM1	Homo sapiens (Human)	1685	FUNCTION: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.		extraocular skeletal muscle development [GO:0002074]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein kinase A signaling [GO:0010737]	M band [GO:0031430]; striated muscle myosin thick filament [GO:0005863]	identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307]	M band [GO:0031430]; striated muscle myosin thick filament [GO:0005863]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307]; extraocular skeletal muscle development [GO:0002074]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein kinase A signaling [GO:0010737]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}.
P52198	reviewed	RND2_HUMAN	Rho-related GTP-binding protein RhoN (Rho family GTPase 2) (Rho-related GTP-binding protein Rho7) (Rnd2)	RND2 ARHN RHO7	Homo sapiens (Human)	227	FUNCTION: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; cell migration [GO:0016477]; collateral sprouting [GO:0048668]; positive regulation of collateral sprouting [GO:0048672]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	acrosomal membrane [GO:0002080]; cytosol [GO:0005829]; early endosome [GO:0005769]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]	acrosomal membrane [GO:0002080]; cytosol [GO:0005829]; early endosome [GO:0005769]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; collateral sprouting [GO:0048668]; positive regulation of collateral sprouting [GO:0048672]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome. {ECO:0000269|PubMed:12590651}.
P52209	reviewed	6PGD_HUMAN	6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)	PGD PGDH	Homo sapiens (Human)	483	FUNCTION: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}.		D-gluconate catabolic process [GO:0046177]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	NADP binding [GO:0050661]; phosphogluconate dehydrogenase (decarboxylating) activity [GO:0004616]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; NADP binding [GO:0050661]; phosphogluconate dehydrogenase (decarboxylating) activity [GO:0004616]; D-gluconate catabolic process [GO:0046177]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
P52272	reviewed	HNRPM_HUMAN	Heterogeneous nuclear ribonucleoprotein M (hnRNP M)	HNRNPM HNRPM NAGR1	Homo sapiens (Human)	730	FUNCTION: Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.		alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; spliceosomal complex [GO:0005681]; synapse [GO:0045202]	mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; spliceosomal complex [GO:0005681]; synapse [GO:0045202]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|Ref.5}.
P52292	reviewed	IMA1_HUMAN	Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)	KPNA2 RCH1 SRP1	Homo sapiens (Human)	529	FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.		DNA metabolic process [GO:0006259]; entry of viral genome into host nucleus through nuclear pore complex via importin [GO:0075506]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of viral life cycle [GO:1903902]; protein import into nucleus [GO:0006606]; regulation of DNA recombination [GO:0000018]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; host cell [GO:0043657]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone deacetylase binding [GO:0042826]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; host cell [GO:0043657]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone deacetylase binding [GO:0042826]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]; DNA metabolic process [GO:0006259]; entry of viral genome into host nucleus through nuclear pore complex via importin [GO:0075506]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of viral life cycle [GO:1903902]; protein import into nucleus [GO:0006606]; regulation of DNA recombination [GO:0000018]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:9020106}. Nucleus {ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:9020106}.; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane. Golgi apparatus membrane {ECO:0000269|PubMed:17596301}. Note=(Microbial infection) Retained in ER/Golgi membranes upon interaction with SARS-COV virus ORF6 protein. {ECO:0000269|PubMed:17596301}.
P52294	reviewed	IMA5_HUMAN	Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]	KPNA1 RCH2	Homo sapiens (Human)	538	FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.		NLS-bearing protein import into nucleus [GO:0006607]; postsynapse to nucleus signaling pathway [GO:0099527]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA recombination [GO:0000018]; satellite cell activation involved in skeletal muscle regeneration [GO:0014901]; skeletal muscle satellite cell proliferation [GO:0014841]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; NLS-bearing protein import into nucleus [GO:0006607]; postsynapse to nucleus signaling pathway [GO:0099527]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA recombination [GO:0000018]; satellite cell activation involved in skeletal muscle regeneration [GO:0014901]; skeletal muscle satellite cell proliferation [GO:0014841]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7604027}. Nucleus {ECO:0000269|PubMed:7604027}.
P52298	reviewed	NCBP2_HUMAN	Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1)	NCBP2 CBP20 PIG55	Homo sapiens (Human)	156	FUNCTION: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858). {ECO:0000269|PubMed:11551508, ECO:0000269|PubMed:15361857, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17363367, ECO:0000269|PubMed:17873884, ECO:0000269|PubMed:18369367, ECO:0000269|PubMed:19632182, ECO:0000269|PubMed:26382858}.		alternative mRNA splicing, via spliceosome [GO:0000380]; cap-dependent translational initiation [GO:0002191]; histone mRNA metabolic process [GO:0008334]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA 3'-end processing [GO:0031124]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA export from nucleus [GO:0006406]; mRNA metabolic process [GO:0016071]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription by RNA polymerase II [GO:0042789]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; primary miRNA processing [GO:0031053]; regulation of translational initiation [GO:0006446]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RNA splicing [GO:0008380]; snRNA export from nucleus [GO:0006408]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mRNA cap binding complex [GO:0005845]; nuclear cap binding complex [GO:0005846]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA cap binding complex [GO:0034518]	DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; snRNA binding [GO:0017069]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mRNA cap binding complex [GO:0005845]; nuclear cap binding complex [GO:0005846]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA cap binding complex [GO:0034518]; DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; snRNA binding [GO:0017069]; alternative mRNA splicing, via spliceosome [GO:0000380]; cap-dependent translational initiation [GO:0002191]; histone mRNA metabolic process [GO:0008334]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA 3'-end processing [GO:0031124]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA export from nucleus [GO:0006406]; mRNA metabolic process [GO:0016071]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription by RNA polymerase II [GO:0042789]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; primary miRNA processing [GO:0031053]; regulation of translational initiation [GO:0006446]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RNA splicing [GO:0008380]; snRNA export from nucleus [GO:0006408]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8601613}. Cytoplasm {ECO:0000269|PubMed:8601613}.
P52306	reviewed	GDS1_HUMAN	Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)	RAP1GDS1 SMGGDS	Homo sapiens (Human)	607	FUNCTION: Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (PubMed:28630045, PubMed:30190425, PubMed:1549351, PubMed:11948427, PubMed:20709748). Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity (PubMed:20709748, PubMed:21242305). Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS (PubMed:1549351, PubMed:11948427, PubMed:20709748, PubMed:24415755). Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions (PubMed:27716788). Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake (PubMed:24349085). {ECO:0000269|PubMed:11948427, ECO:0000269|PubMed:1549351, ECO:0000269|PubMed:20709748, ECO:0000269|PubMed:21242305, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:24415755, ECO:0000269|PubMed:27716788, ECO:0000269|PubMed:28630045, ECO:0000269|PubMed:30190425, ECO:0000305|PubMed:30190425}.; FUNCTION: [Isoform 1]: Acts as a GEF (guanine nucleotide exchange factor) for unprenylated RHOA (PubMed:30190425, PubMed:28630045, PubMed:24415755). Chaperones the entry and passage of small GTPases through the prenylation pathway (PubMed:20709748). Recognizes the last amino acid in the GTPase C-terminal CAAX motif with a preference for 'Leu' over 'Met', indicating involvement in the geranylgeranylation pathway (PubMed:24415755). {ECO:0000269|PubMed:20709748, ECO:0000269|PubMed:24415755, ECO:0000269|PubMed:28630045, ECO:0000269|PubMed:30190425}.; FUNCTION: [Isoform 2]: Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA (PubMed:28630045, PubMed:30190425, PubMed:21242305). Acts as a GEF for RHOC (PubMed:21242305). Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases (PubMed:20709748). Escorts RAC1 to the nucleus (PubMed:12551911). {ECO:0000269|PubMed:12551911, ECO:0000269|PubMed:20709748, ECO:0000269|PubMed:21242305, ECO:0000269|PubMed:28630045, ECO:0000269|PubMed:30190425}.		angiotensin-activated signaling pathway involved in heart process [GO:0086098]; CAAX-box protein maturation [GO:0080120]; cardiac muscle hypertrophy [GO:0003300]; myosin filament assembly [GO:0031034]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; protein localization to nucleus [GO:0034504]; regulation of ERK5 cascade [GO:0070376]; regulation of matrix metallopeptidase secretion [GO:1904464]; regulation of mitochondrion organization [GO:0010821]; vascular associated smooth muscle contraction [GO:0014829]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; guanyl-nucleotide exchange factor activity [GO:0005085]; angiotensin-activated signaling pathway involved in heart process [GO:0086098]; CAAX-box protein maturation [GO:0080120]; cardiac muscle hypertrophy [GO:0003300]; myosin filament assembly [GO:0031034]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; protein localization to nucleus [GO:0034504]; regulation of ERK5 cascade [GO:0070376]; regulation of matrix metallopeptidase secretion [GO:1904464]; regulation of mitochondrion organization [GO:0010821]; vascular associated smooth muscle contraction [GO:0014829]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24349085}. Endoplasmic reticulum {ECO:0000269|PubMed:24349085}. Mitochondrion {ECO:0000269|PubMed:24349085}. Nucleus {ECO:0000269|PubMed:12551911}. Note=Nuclear import is dependent on complexing with a GTPase containing a C-terminal polybasic region. {ECO:0000269|PubMed:12551911}.
P52333	reviewed	JAK3_HUMAN	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)	JAK3	Homo sapiens (Human)	1124	FUNCTION: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:20440074, ECO:0000269|PubMed:7662955, ECO:0000269|PubMed:8022485}.	MISCELLANEOUS: [Isoform 1]: May be inactive as it lacks some part of the kinase domain. {ECO:0000305}.	adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; cell differentiation [GO:0030154]; cytokine-mediated signaling pathway [GO:0019221]; enzyme-linked receptor protein signaling pathway [GO:0007167]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; innate immune response [GO:0045087]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular signal transduction [GO:0035556]; negative regulation of dendritic cell cytokine production [GO:0002731]; negative regulation of FasL production [GO:0045221]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of T cell activation [GO:0050868]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of thymocyte apoptotic process [GO:0070244]; peptidyl-tyrosine phosphorylation [GO:0018108]; protein phosphorylation [GO:0006468]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of apoptotic process [GO:0042981]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of T cell apoptotic process [GO:0070232]; response to interleukin-15 [GO:0070672]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to interleukin-9 [GO:0071104]; T cell homeostasis [GO:0043029]; tyrosine phosphorylation of STAT protein [GO:0007260]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; cell differentiation [GO:0030154]; cytokine-mediated signaling pathway [GO:0019221]; enzyme-linked receptor protein signaling pathway [GO:0007167]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; innate immune response [GO:0045087]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular signal transduction [GO:0035556]; negative regulation of dendritic cell cytokine production [GO:0002731]; negative regulation of FasL production [GO:0045221]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of T cell activation [GO:0050868]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of thymocyte apoptotic process [GO:0070244]; peptidyl-tyrosine phosphorylation [GO:0018108]; protein phosphorylation [GO:0006468]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of apoptotic process [GO:0042981]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of T cell apoptotic process [GO:0070232]; response to interleukin-15 [GO:0070672]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to interleukin-9 [GO:0071104]; T cell homeostasis [GO:0043029]; tyrosine phosphorylation of STAT protein [GO:0007260]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
P52429	reviewed	DGKE_HUMAN	Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon)	DGKE DAGK5	Homo sapiens (Human)	567	FUNCTION: Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:19744926, PubMed:22108654, PubMed:21477596, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:8626589, PubMed:15544348). Also plays an important role in the biosynthesis of complex lipids (PubMed:8626589). Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:19744926, PubMed:22108654, PubMed:23274426). Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (PubMed:22108654). {ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:19744926, ECO:0000269|PubMed:21477596, ECO:0000269|PubMed:22108654, ECO:0000269|PubMed:23274426, ECO:0000269|PubMed:23949095, ECO:0000303|PubMed:15544348, ECO:0000303|PubMed:8626589}.		diacylglycerol metabolic process [GO:0046339]; lipid phosphorylation [GO:0046834]; modulation of chemical synaptic transmission [GO:0050804]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol biosynthetic process [GO:0006661]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; diacylglycerol metabolic process [GO:0046339]; lipid phosphorylation [GO:0046834]; modulation of chemical synaptic transmission [GO:0050804]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol biosynthetic process [GO:0006661]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:23542698}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:23542698}.
P52434	reviewed	RPAB3_HUMAN	DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide) (RPB17) (RPB8 homolog) (hRPB8)	POLR2H	Homo sapiens (Human)	150	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. {ECO:0000269|PubMed:9852112}.		transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]	DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; single-stranded DNA binding [GO:0003697]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; single-stranded DNA binding [GO:0003697]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:9852112, ECO:0000269|Ref.6}.
P52435	reviewed	RPB11_HUMAN	DNA-directed RNA polymerase II subunit RPB11-a (RNA polymerase II subunit B11-a) (RPB11a) (DNA-directed RNA polymerase II subunit J-1) (RNA polymerase II 13.3 kDa subunit)	POLR2J POLR2J1	Homo sapiens (Human)	117	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.		transcription by RNA polymerase II [GO:0006366]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; LRR domain binding [GO:0030275]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; LRR domain binding [GO:0030275]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
P52564	reviewed	MP2K6_HUMAN	Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)	MAP2K6 MEK6 MKK6 PRKMK6 SKK3	Homo sapiens (Human)	334	FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases. {ECO:0000269|PubMed:10961885, ECO:0000269|PubMed:11727828, ECO:0000269|PubMed:15550393, ECO:0000269|PubMed:20869211, ECO:0000269|PubMed:8622669, ECO:0000269|PubMed:8626699, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9218798}.		apoptotic process [GO:0006915]; bone development [GO:0060348]; cardiac muscle contraction [GO:0060048]; cellular response to sorbitol [GO:0072709]; cellular senescence [GO:0090398]; MAPK cascade [GO:0000165]; negative regulation of cold-induced thermogenesis [GO:0120163]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; osteoblast differentiation [GO:0001649]; ovulation cycle process [GO:0022602]; p38MAPK cascade [GO:0038066]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to ischemia [GO:0002931]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; MAP kinase kinase activity [GO:0004708]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; MAP kinase kinase activity [GO:0004708]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; apoptotic process [GO:0006915]; bone development [GO:0060348]; cardiac muscle contraction [GO:0060048]; cellular response to sorbitol [GO:0072709]; cellular senescence [GO:0090398]; MAPK cascade [GO:0000165]; negative regulation of cold-induced thermogenesis [GO:0120163]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; osteoblast differentiation [GO:0001649]; ovulation cycle process [GO:0022602]; p38MAPK cascade [GO:0038066]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to ischemia [GO:0002931]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9768359}. Cytoplasm {ECO:0000269|PubMed:9768359}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9768359}. Note=Binds to microtubules.
P52565	reviewed	GDIR1_HUMAN	Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)	ARHGDIA GDIA1	Homo sapiens (Human)	204	FUNCTION: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}.		negative regulation of apoptotic process [GO:0043066]; regulation of protein localization [GO:0032880]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synaptic vesicle cycle [GO:0098693]; Rho protein signal transduction [GO:0007266]; semaphorin-plexin signaling pathway [GO:0071526]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; membrane [GO:0016020]; nucleus [GO:0005634]; Schaffer collateral - CA1 synapse [GO:0098685]	GTPase activator activity [GO:0005096]; Rho GDP-dissociation inhibitor activity [GO:0005094]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; membrane [GO:0016020]; nucleus [GO:0005634]; Schaffer collateral - CA1 synapse [GO:0098685]; GTPase activator activity [GO:0005096]; Rho GDP-dissociation inhibitor activity [GO:0005094]; negative regulation of apoptotic process [GO:0043066]; regulation of protein localization [GO:0032880]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synaptic vesicle cycle [GO:0098693]; Rho protein signal transduction [GO:0007266]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23434736}.
P52566	reviewed	GDIR2_HUMAN	Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta)	ARHGDIB GDIA2 GDID4 RAP1GN1	Homo sapiens (Human)	201	FUNCTION: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). {ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133, ECO:0000269|PubMed:8356058}.		cellular response to redox state [GO:0071461]; negative regulation of trophoblast cell migration [GO:1901164]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; Rho GDP-dissociation inhibitor activity [GO:0005094]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; Rho GDP-dissociation inhibitor activity [GO:0005094]; small GTPase binding [GO:0031267]; cellular response to redox state [GO:0071461]; negative regulation of trophoblast cell migration [GO:1901164]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10802295}.
P52569	reviewed	CTR2_HUMAN	Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)	SLC7A2 ATRC2 CAT2	Homo sapiens (Human)	658	FUNCTION: Functions as permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:9174363, PubMed:28684763). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity). {ECO:0000250|UniProtKB:P18581, ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 1]: Functions as permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2. {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 2]: Functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.		amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-ornithine transmembrane transport [GO:1903352]; transport across blood-brain barrier [GO:0150104]	cell junction [GO:0030054]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]	cell junction [GO:0030054]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-ornithine transmembrane transport [GO:1903352]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9174363}; Multi-pass membrane protein {ECO:0000269|PubMed:9174363}.
P52594	reviewed	AGFG1_HUMAN	Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein)	AGFG1 HRB RAB RIP	Homo sapiens (Human)	562	FUNCTION: Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}.		acrosome assembly [GO:0001675]; intermediate filament organization [GO:0045109]; mRNA export from nucleus [GO:0006406]; spermatid nucleus differentiation [GO:0007289]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear pore [GO:0005643]	DNA binding [GO:0003677]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear pore [GO:0005643]; DNA binding [GO:0003677]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; acrosome assembly [GO:0001675]; intermediate filament organization [GO:0045109]; mRNA export from nucleus [GO:0006406]; spermatid nucleus differentiation [GO:0007289]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:7634337}. Cytoplasmic vesicle {ECO:0000269|PubMed:10613896}.
P52597	reviewed	HNRPF_HUMAN	Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]	HNRNPF HNRPF	Homo sapiens (Human)	415	FUNCTION: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}.		mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]	RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm.
P52630	reviewed	STAT2_HUMAN	Signal transducer and activator of transcription 2 (p113)	STAT2	Homo sapiens (Human)	851	FUNCTION: Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121, PubMed:23391734, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}.	MISCELLANEOUS: [Isoform 2]: May be due to competing acceptor splice site. {ECO:0000305}.	defense response [GO:0006952]; defense response to virus [GO:0051607]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell population proliferation [GO:0042127]; regulation of mitochondrial fission [GO:0090140]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; type I interferon-mediated signaling pathway [GO:0060337]	chromatin [GO:0000785]; cytosol [GO:0005829]; ISGF3 complex [GO:0070721]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin-like protein ligase binding [GO:0044389]	chromatin [GO:0000785]; cytosol [GO:0005829]; ISGF3 complex [GO:0070721]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin-like protein ligase binding [GO:0044389]; defense response [GO:0006952]; defense response to virus [GO:0051607]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell population proliferation [GO:0042127]; regulation of mitochondrial fission [GO:0090140]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11150296, ECO:0000269|PubMed:23139419, ECO:0000269|PubMed:27782195}. Nucleus {ECO:0000269|PubMed:11150296, ECO:0000269|PubMed:23139419}. Note=Translocated into the nucleus upon activation by IFN-alpha/beta. {ECO:0000269|PubMed:11150296, ECO:0000269|PubMed:23139419}.
P52655	reviewed	TF2AA_HUMAN	Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)]	GTF2A1 TF2A1	Homo sapiens (Human)	376	FUNCTION: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333, ECO:0000269|PubMed:16537915}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIA complex [GO:0005672]; transcription factor TFIID complex [GO:0005669]; transcription preinitiation complex [GO:0097550]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; TBP-class protein binding [GO:0017025]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIA complex [GO:0005672]; transcription factor TFIID complex [GO:0005669]; transcription preinitiation complex [GO:0097550]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; TBP-class protein binding [GO:0017025]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
P52657	reviewed	T2AG_HUMAN	Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (TFIIA p12 subunit) (TFIIA-12) (TFIIAS) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma)	GTF2A2 TF2A2	Homo sapiens (Human)	109	FUNCTION: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	cell junction [GO:0030054]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIA complex [GO:0005672]; transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; TBP-class protein binding [GO:0017025]	cell junction [GO:0030054]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIA complex [GO:0005672]; transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; TBP-class protein binding [GO:0017025]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus.
P52701	reviewed	MSH6_HUMAN	DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)	MSH6 GTBP	Homo sapiens (Human)	1360	FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}.		determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; isotype switching [GO:0045190]; meiotic mismatch repair [GO:0000710]; mismatch repair [GO:0006298]; negative regulation of DNA recombination [GO:0045910]; positive regulation of helicase activity [GO:0051096]; response to UV [GO:0009411]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; MutSalpha complex [GO:0032301]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; enzyme binding [GO:0019899]; guanine/thymine mispair binding [GO:0032137]; methylated histone binding [GO:0035064]; mismatched DNA binding [GO:0030983]	chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; MutSalpha complex [GO:0032301]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; enzyme binding [GO:0019899]; guanine/thymine mispair binding [GO:0032137]; methylated histone binding [GO:0035064]; mismatched DNA binding [GO:0030983]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; isotype switching [GO:0045190]; meiotic mismatch repair [GO:0000710]; mismatch repair [GO:0006298]; negative regulation of DNA recombination [GO:0045910]; positive regulation of helicase activity [GO:0051096]; response to UV [GO:0009411]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23622243}. Chromosome {ECO:0000269|PubMed:23622243}. Note=Associates with H3K36me3 via its PWWP domain.
P52732	reviewed	KIF11_HUMAN	Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5)	KIF11 EG5 KNSL1 TRIP5	Homo sapiens (Human)	1056	FUNCTION: Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}.		cell division [GO:0051301]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic centrosome separation [GO:0007100]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; regulation of mitotic centrosome separation [GO:0046602]; spindle elongation [GO:0051231]; spindle organization [GO:0007051]	cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein kinase binding [GO:0019901]	cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein kinase binding [GO:0019901]; cell division [GO:0051301]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic centrosome separation [GO:0007100]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; regulation of mitotic centrosome separation [GO:0046602]; spindle elongation [GO:0051231]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19001501}.
P52735	reviewed	VAV2_HUMAN	Guanine nucleotide exchange factor VAV2 (VAV-2)	VAV2	Homo sapiens (Human)	878	FUNCTION: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}.		angiogenesis [GO:0001525]; cell migration [GO:0016477]; cellular response to xenobiotic stimulus [GO:0071466]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; lamellipodium assembly [GO:0030032]; platelet activation [GO:0030168]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	epidermal growth factor receptor binding [GO:0005154]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphotyrosine residue binding [GO:0001784]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; epidermal growth factor receptor binding [GO:0005154]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphotyrosine residue binding [GO:0001784]; angiogenesis [GO:0001525]; cell migration [GO:0016477]; cellular response to xenobiotic stimulus [GO:0071466]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; lamellipodium assembly [GO:0030032]; platelet activation [GO:0030168]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	
P52736	reviewed	ZN133_HUMAN	Zinc finger protein 133 (Zinc finger protein 150)	ZNF133 ZNF150	Homo sapiens (Human)	654	FUNCTION: May be involved in transcriptional regulation as a repressor.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P52738	reviewed	ZN140_HUMAN	Zinc finger protein 140	ZNF140	Homo sapiens (Human)	457	FUNCTION: May be involved in transcriptional regulation as a repressor.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P52739	reviewed	ZN131_HUMAN	Zinc finger protein 131	ZNF131	Homo sapiens (Human)	623	FUNCTION: Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. {ECO:0000250, ECO:0000269|PubMed:18847501, ECO:0000269|PubMed:22467880}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17306895, ECO:0000269|PubMed:22467880, ECO:0000269|PubMed:23404503}. Note=Sumoylation does not affect nuclear localization.
P52742	reviewed	ZN135_HUMAN	Zinc finger protein 135 (Zinc finger protein 61) (Zinc finger protein 78-like 1)	ZNF135 ZNF61 ZNF78L1	Homo sapiens (Human)	658	FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation. {ECO:0000269|PubMed:21834987}.	MISCELLANEOUS: [Isoform 3]: May be due to competing acceptor splice site. {ECO:0000305}.	cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P52744	reviewed	ZN138_HUMAN	Zinc finger protein 138	ZNF138	Homo sapiens (Human)	262	FUNCTION: May be involved in transcriptional regulation as a repressor.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P52747	reviewed	ZN143_HUMAN	Zinc finger protein 143 (SPH-binding factor) (Selenocysteine tRNA gene transcription-activating factor) (hStaf)	ZNF143 SBF STAF	Homo sapiens (Human)	638	FUNCTION: Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8. {ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:9776743}.		positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription by RNA polymerase III [GO:0006359]	nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription by RNA polymerase III [GO:0006359]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P52756	reviewed	RBM5_HUMAN	RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9)	RBM5 H37 LUCA15	Homo sapiens (Human)	815	FUNCTION: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835}.		apoptotic process [GO:0006915]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA processing [GO:0006396]; spliceosomal complex assembly [GO:0000245]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA processing [GO:0006396]; spliceosomal complex assembly [GO:0000245]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18851835}.
P52757	reviewed	CHIO_HUMAN	Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3)	CHN2 ARHGAP3 BCH	Homo sapiens (Human)	468	FUNCTION: GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.		regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]; membrane [GO:0016020]; synapse [GO:0045202]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; membrane [GO:0016020]; synapse [GO:0045202]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
P52758	reviewed	RIDA_HUMAN	2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (14.5 kDa translational inhibitor protein) (hp14.5) (p14.5) (Heat-responsive protein 12) (Reactive intermediate imine deaminase A homolog) (Translation inhibitor L-PSP ribonuclease) (UK114 antigen homolog)	RIDA HRSP12	Homo sapiens (Human)	137	FUNCTION: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. {ECO:0000269|PubMed:20817725, ECO:0000269|PubMed:22094463}.; FUNCTION: Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex (PubMed:8973653, PubMed:30930054). Acts by bridging YTHDF2 and the ribonuclease P/MRP complex (PubMed:30930054). RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage (PubMed:30930054). {ECO:0000269|PubMed:30930054, ECO:0000269|PubMed:8973653}.		L-threonine catabolic process to glycine [GO:0019518]; lipid metabolic process [GO:0006629]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; negative regulation of translation [GO:0017148]; organonitrogen compound catabolic process [GO:1901565]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisome [GO:0005777]	2-iminobutanoate deaminase activity [GO:0120242]; 2-iminopropanoate deaminase activity [GO:0120243]; deaminase activity [GO:0019239]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA endonuclease activity, producing 3'-phosphomonoesters [GO:0016892]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisome [GO:0005777]; 2-iminobutanoate deaminase activity [GO:0120242]; 2-iminopropanoate deaminase activity [GO:0120243]; deaminase activity [GO:0019239]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA endonuclease activity, producing 3'-phosphomonoesters [GO:0016892]; L-threonine catabolic process to glycine [GO:0019518]; lipid metabolic process [GO:0006629]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; negative regulation of translation [GO:0017148]; organonitrogen compound catabolic process [GO:1901565]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8973653}. Nucleus {ECO:0000269|PubMed:8973653}. Peroxisome {ECO:0000250|UniProtKB:P52759}. Mitochondrion {ECO:0000250|UniProtKB:P52759}. Note=Mostly cytoplasmic but, in less differentiated cells occasionally nuclear. {ECO:0000269|PubMed:8973653}.
P52788	reviewed	SPSY_HUMAN	Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase)	SMS	Homo sapiens (Human)	366	FUNCTION: Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). {ECO:0000269|PubMed:18367445, ECO:0000269|PubMed:18550699, ECO:0000269|PubMed:23696453, ECO:0000269|PubMed:23897707}.		methionine metabolic process [GO:0006555]; polyamine metabolic process [GO:0006595]; spermine biosynthetic process [GO:0006597]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; spermine synthase activity [GO:0016768]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; spermine synthase activity [GO:0016768]; methionine metabolic process [GO:0006555]; polyamine metabolic process [GO:0006595]; spermine biosynthetic process [GO:0006597]	
P52789	reviewed	HXK2_HUMAN	Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase)	HK2	Homo sapiens (Human)	917	FUNCTION: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}.		apoptotic mitochondrial changes [GO:0008637]; canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; cellular response to leukemia inhibitory factor [GO:1990830]; establishment of protein localization to mitochondrion [GO:0072655]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]; lactation [GO:0007595]; maintenance of protein location in mitochondrion [GO:0072656]; negative regulation of mitochondrial membrane permeability [GO:0035795]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [GO:1904925]; regulation of glucose import [GO:0046324]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]	centrosome [GO:0005813]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; sarcoplasmic reticulum [GO:0016529]	ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucose binding [GO:0005536]; hexokinase activity [GO:0004396]	centrosome [GO:0005813]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; sarcoplasmic reticulum [GO:0016529]; ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucose binding [GO:0005536]; hexokinase activity [GO:0004396]; apoptotic mitochondrial changes [GO:0008637]; canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; cellular response to leukemia inhibitory factor [GO:1990830]; establishment of protein localization to mitochondrion [GO:0072655]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]; lactation [GO:0007595]; maintenance of protein location in mitochondrion [GO:0072656]; negative regulation of mitochondrial membrane permeability [GO:0035795]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [GO:1904925]; regulation of glucose import [GO:0046324]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18350175}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:18350175}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880). Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:29298880}.
P52790	reviewed	HXK3_HUMAN	Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III) (Hexokinase-C)	HK3	Homo sapiens (Human)	923	FUNCTION: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:8717435). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:8717435). {ECO:0000269|PubMed:8717435}.		canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; secretory granule lumen [GO:0034774]	ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucose binding [GO:0005536]; hexokinase activity [GO:0004396]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; secretory granule lumen [GO:0034774]; ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucose binding [GO:0005536]; hexokinase activity [GO:0004396]; canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]	
P52797	reviewed	EFNA3_HUMAN	Ephrin-A3 (EFL-2) (EHK1 ligand) (EHK1-L) (EPH-related receptor tyrosine kinase ligand 3) (LERK-3)	EFNA3 EFL2 EPLG3 LERK3	Homo sapiens (Human)	238	FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of angiogenesis [GO:0016525]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; regulation of neuron differentiation [GO:0045664]	plasma membrane [GO:0005886]; side of membrane [GO:0098552]	ephrin receptor binding [GO:0046875]; transmembrane-ephrin receptor activity [GO:0005005]	plasma membrane [GO:0005886]; side of membrane [GO:0098552]; ephrin receptor binding [GO:0046875]; transmembrane-ephrin receptor activity [GO:0005005]; axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of angiogenesis [GO:0016525]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; regulation of neuron differentiation [GO:0045664]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
P52798	reviewed	EFNA4_HUMAN	Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4)	EFNA4 EPLG4 LERK4	Homo sapiens (Human)	201	FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.		axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	ephrin receptor binding [GO:0046875]; transmembrane-ephrin receptor activity [GO:0005005]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; ephrin receptor binding [GO:0046875]; transmembrane-ephrin receptor activity [GO:0005005]; axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
P52799	reviewed	EFNB2_HUMAN	Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)	EFNB2 EPLG5 HTKL LERK5	Homo sapiens (Human)	333	FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}.; FUNCTION: (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. {ECO:0000269|PubMed:15998730, ECO:0000269|PubMed:16007075, ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}.		adherens junction organization [GO:0034332]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]; keratinocyte proliferation [GO:0043616]; lymph vessel development [GO:0001945]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of neuron projection development [GO:0010977]; nephric duct morphogenesis [GO:0072178]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell population proliferation [GO:0008284]; regulation of chemotaxis [GO:0050920]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; T cell costimulation [GO:0031295]; venous blood vessel morphogenesis [GO:0048845]	adherens junction [GO:0005912]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]	ephrin receptor binding [GO:0046875]; virus receptor activity [GO:0001618]	adherens junction [GO:0005912]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; ephrin receptor binding [GO:0046875]; virus receptor activity [GO:0001618]; adherens junction organization [GO:0034332]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]; keratinocyte proliferation [GO:0043616]; lymph vessel development [GO:0001945]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of neuron projection development [GO:0010977]; nephric duct morphogenesis [GO:0072178]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell population proliferation [GO:0008284]; regulation of chemotaxis [GO:0050920]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; T cell costimulation [GO:0031295]; venous blood vessel morphogenesis [GO:0048845]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28931592}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P52800}.
P52803	reviewed	EFNA5_HUMAN	Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)	EFNA5 EPLG7 LERK7	Homo sapiens (Human)	228	FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. {ECO:0000269|PubMed:10601038, ECO:0000269|PubMed:11870224}.		axon guidance [GO:0007411]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to forskolin [GO:1904322]; collateral sprouting [GO:0048668]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; nervous system development [GO:0007399]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of synapse assembly [GO:0051965]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell morphogenesis [GO:0022604]; regulation of cell-cell adhesion [GO:0022407]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of microtubule cytoskeleton organization [GO:0070507]; retinal ganglion cell axon guidance [GO:0031290]; synaptic membrane adhesion [GO:0099560]	adherens junction [GO:0005912]; basement membrane [GO:0005604]; caveola [GO:0005901]; external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]	chemorepellent activity [GO:0045499]; ephrin receptor binding [GO:0046875]; neurotrophin TRKA receptor binding [GO:0005168]; neurotrophin TRKB receptor binding [GO:0005169]; neurotrophin TRKC receptor binding [GO:0005170]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	adherens junction [GO:0005912]; basement membrane [GO:0005604]; caveola [GO:0005901]; external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; chemorepellent activity [GO:0045499]; ephrin receptor binding [GO:0046875]; neurotrophin TRKA receptor binding [GO:0005168]; neurotrophin TRKB receptor binding [GO:0005169]; neurotrophin TRKC receptor binding [GO:0005170]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; axon guidance [GO:0007411]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to forskolin [GO:1904322]; collateral sprouting [GO:0048668]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; nervous system development [GO:0007399]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of synapse assembly [GO:0051965]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell morphogenesis [GO:0022604]; regulation of cell-cell adhesion [GO:0022407]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of microtubule cytoskeleton organization [GO:0070507]; retinal ganglion cell axon guidance [GO:0031290]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11870224}. Membrane, caveola {ECO:0000269|PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11870224}. Note=Compartmentalized in discrete caveolae-like membrane microdomains.
P52815	reviewed	RM12_HUMAN	Large ribosomal subunit protein bL12m (39S ribosomal protein L12, mitochondrial) (L12mt) (MRP-L12) (5c5-2)	MRPL12 MRPL7 RPML12	Homo sapiens (Human)	198	FUNCTION: As a component of the mitochondrial large ribosomal subunit, it plays a role in mitochondrial translation (PubMed:23603806). Associates with mitochondrial RNA polymerase to activate transcription. {ECO:0000269|PubMed:22003127, ECO:0000269|PubMed:23603806}.		mitochondrial transcription [GO:0006390]; mitochondrial translation [GO:0032543]; positive regulation of DNA-templated transcription [GO:0045893]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial transcription [GO:0006390]; mitochondrial translation [GO:0032543]; positive regulation of DNA-templated transcription [GO:0045893]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:27184847, ECO:0000269|PubMed:8626705}.
P52823	reviewed	STC1_HUMAN	Stanniocalcin-1 (STC-1)	STC1 STC	Homo sapiens (Human)	247	FUNCTION: Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.		bone development [GO:0060348]; cellular response to cAMP [GO:0071320]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hypoxia [GO:0071456]; chondrocyte proliferation [GO:0035988]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; endothelial cell morphogenesis [GO:0001886]; growth plate cartilage axis specification [GO:0003421]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of renal phosphate excretion [GO:1903403]; ossification [GO:0001503]; positive regulation of calcium ion import [GO:0090280]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of monoatomic anion transport [GO:0044070]; response to vitamin D [GO:0033280]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]	hormone activity [GO:0005179]; identical protein binding [GO:0042802]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; bone development [GO:0060348]; cellular response to cAMP [GO:0071320]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hypoxia [GO:0071456]; chondrocyte proliferation [GO:0035988]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; endothelial cell morphogenesis [GO:0001886]; growth plate cartilage axis specification [GO:0003421]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of renal phosphate excretion [GO:1903403]; ossification [GO:0001503]; positive regulation of calcium ion import [GO:0090280]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of monoatomic anion transport [GO:0044070]; response to vitamin D [GO:0033280]	SUBCELLULAR LOCATION: Secreted.
P52824	reviewed	DGKQ_HUMAN	Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta)	DGKQ DAGK4	Homo sapiens (Human)	942	FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9099683, PubMed:11309392, PubMed:22627129). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:11309392, ECO:0000269|PubMed:17664281, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:26748701, ECO:0000269|PubMed:9099683}.		cAMP-mediated signaling [GO:0019933]; diacylglycerol metabolic process [GO:0046339]; G protein-coupled receptor signaling pathway [GO:0007186]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of gene expression [GO:0010629]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein kinase C signaling [GO:0070528]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of cholesterol metabolic process [GO:0090181]; regulation of cortisol biosynthetic process [GO:2000064]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of gluconeogenesis [GO:0006111]; regulation of progesterone biosynthetic process [GO:2000182]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of TORC1 signaling [GO:1903432]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ATP [GO:0033198]; response to cAMP [GO:0051591]; thrombin-activated receptor signaling pathway [GO:0070493]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; vesicle membrane [GO:0012506]	ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; DNA-binding transcription factor binding [GO:0140297]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; phospholipase binding [GO:0043274]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; vesicle membrane [GO:0012506]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; DNA-binding transcription factor binding [GO:0140297]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; phospholipase binding [GO:0043274]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; cAMP-mediated signaling [GO:0019933]; diacylglycerol metabolic process [GO:0046339]; G protein-coupled receptor signaling pathway [GO:0007186]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of gene expression [GO:0010629]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein kinase C signaling [GO:0070528]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of cholesterol metabolic process [GO:0090181]; regulation of cortisol biosynthetic process [GO:2000064]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of gluconeogenesis [GO:0006111]; regulation of progesterone biosynthetic process [GO:2000182]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of TORC1 signaling [GO:1903432]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ATP [GO:0033198]; response to cAMP [GO:0051591]; thrombin-activated receptor signaling pathway [GO:0070493]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15632189}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6P5E8}. Cell membrane {ECO:0000269|PubMed:10066731, ECO:0000269|PubMed:15632189}. Synapse {ECO:0000250|UniProtKB:Q6P5E8}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10066731}. Nucleus {ECO:0000269|PubMed:12799190}. Nucleus speckle {ECO:0000269|PubMed:12799190}. Nucleus matrix {ECO:0000250|UniProtKB:D3ZEY4}. Note=Translocates to the plasma membrane in response to steroid hormone receptor stimulation (PubMed:15632189). Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH (PubMed:15632189). Translocates to the nucleus in response to thrombin stimulation (Probable). Association with the nuclear matrix is regulated by nerve growth factor (By similarity). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:15632189, ECO:0000305|PubMed:11309392}.
P52848	reviewed	NDST1_HUMAN	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (Glucosaminyl N-deacetylase/N-sulfotransferase 1) (NDST-1) (N-heparan sulfate sulfotransferase 1) (N-HSST 1) ([Heparan sulfate]-glucosamine N-sulfotransferase 1) (HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 (EC 3.5.1.-); Heparan sulfate N-sulfotransferase 1 (EC 2.8.2.8)]	NDST1 HSST HSST1	Homo sapiens (Human)	882	FUNCTION: [Isoform 1]: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:9230113, PubMed:9744796, PubMed:35137078). Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:9230113). Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000250|UniProtKB:Q3UHN9, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:9230113}.; FUNCTION: [Isoform 3]: Lacks both N-deacetylase and N-sulfotransferase activities. Acts as a dominant negative on isoform 1, likely by changing the composition of enzyme complexes responsible for elongation and modification of heparan sulfates. {ECO:0000269|PubMed:35137078}.	MISCELLANEOUS: The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences.; MISCELLANEOUS: [Isoform 3]: The increased expression in several types of cancer is associated with shorter survival. {ECO:0000305|PubMed:35137078}.	aorta development [GO:0035904]; cardiac septum development [GO:0003279]; cell population proliferation [GO:0008283]; coronary vasculature development [GO:0060976]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; fibroblast growth factor receptor signaling pathway [GO:0008543]; forebrain development [GO:0030900]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; inflammatory response [GO:0006954]; midbrain development [GO:0030901]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smoothened signaling pathway [GO:0045880]; respiratory gaseous exchange by respiratory system [GO:0007585]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network membrane [GO:0032588]	[heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]; N-acetylglucosamine deacetylase activity [GO:0050119]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network membrane [GO:0032588]; [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]; N-acetylglucosamine deacetylase activity [GO:0050119]; aorta development [GO:0035904]; cardiac septum development [GO:0003279]; cell population proliferation [GO:0008283]; coronary vasculature development [GO:0060976]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; fibroblast growth factor receptor signaling pathway [GO:0008543]; forebrain development [GO:0030900]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; inflammatory response [GO:0006954]; midbrain development [GO:0030901]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smoothened signaling pathway [GO:0045880]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:9230113}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:35137078}; Single-pass type II membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:35137078}; Single-pass type II membrane protein {ECO:0000255}.
P52849	reviewed	NDST2_HUMAN	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 2) (NDST-2) (N-heparan sulfate sulfotransferase 2) (N-HSST 2) [Includes: Heparan sulfate N-deacetylase 2 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 2 (EC 2.8.2.-)]	NDST2 HSST2	Homo sapiens (Human)	883	FUNCTION: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:10758005, ECO:0000269|PubMed:12634318, ECO:0000269|PubMed:16343444, ECO:0000269|PubMed:22660413}.	MISCELLANEOUS: The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences.	heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; mast cell mediated immunity [GO:0002448]; regulation of angiotensin levels in blood [GO:0002002]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	[heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]; N-acetylglucosamine deacetylase activity [GO:0050119]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]; N-acetylglucosamine deacetylase activity [GO:0050119]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; mast cell mediated immunity [GO:0002448]; regulation of angiotensin levels in blood [GO:0002002]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
P52888	reviewed	THOP1_HUMAN	Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78)	THOP1	Homo sapiens (Human)	689	FUNCTION: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:7639763, PubMed:17251185). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:7639763, PubMed:17251185). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P24155, ECO:0000269|PubMed:17251185, ECO:0000269|PubMed:7639763}.		peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]	cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47788}.
P52895	reviewed	AK1C2_HUMAN	Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357)	AKR1C2 DDH2	Homo sapiens (Human)	323	FUNCTION: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:15929998, PubMed:17034817, PubMed:17442338, PubMed:8573067). Also specifically able to produce 17beta-hydroxy-5alpha-androstan-3-one/5alphaDHT (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699, ECO:0000269|PubMed:8573067}.		cellular response to jasmonic acid stimulus [GO:0071395]; cellular response to prostaglandin D stimulus [GO:0071799]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; epithelial cell differentiation [GO:0030855]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; steroid metabolic process [GO:0008202]	cytosol [GO:0005829]	alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; carboxylic acid binding [GO:0031406]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; indanol dehydrogenase activity [GO:0047718]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; phenanthrene 9,10-monooxygenase activity [GO:0018636]; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115]	cytosol [GO:0005829]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; carboxylic acid binding [GO:0031406]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; indanol dehydrogenase activity [GO:0047718]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; phenanthrene 9,10-monooxygenase activity [GO:0018636]; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115]; cellular response to jasmonic acid stimulus [GO:0071395]; cellular response to prostaglandin D stimulus [GO:0071799]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; epithelial cell differentiation [GO:0030855]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; steroid metabolic process [GO:0008202]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:8486699}.
P52907	reviewed	CAZA1_HUMAN	F-actin-capping protein subunit alpha-1 (CapZ alpha-1)	CAPZA1	Homo sapiens (Human)	286	FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}.		actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]; cell junction assembly [GO:0034329]; protein-containing complex assembly [GO:0065003]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; F-actin capping protein complex [GO:0008290]; WASH complex [GO:0071203]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; F-actin capping protein complex [GO:0008290]; WASH complex [GO:0071203]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]; cell junction assembly [GO:0034329]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0PFK5}.
P52926	reviewed	HMGA2_HUMAN	High mobility group protein HMGI-C (High mobility group AT-hook protein 2)	HMGA2 HMGIC	Homo sapiens (Human)	109	FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}.		base-excision repair [GO:0006284]; cell cycle [GO:0007049]; cell division [GO:0051301]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; chromatin organization [GO:0006325]; chromosome condensation [GO:0030261]; endodermal cell differentiation [GO:0035987]; epithelial to mesenchymal transition [GO:0001837]; fat cell differentiation [GO:0045444]; heterochromatin formation [GO:0031507]; intracellular signal transduction [GO:0035556]; mesenchymal cell differentiation [GO:0048762]; mesodermal cell differentiation [GO:0048333]; mesodermal-endodermal cell signaling [GO:0003131]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oncogene-induced cell senescence [GO:0090402]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle process [GO:0010564]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell population maintenance [GO:2000036]; response to virus [GO:0009615]; stem cell differentiation [GO:0048863]	nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; senescence-associated heterochromatin focus [GO:0035985]; SMAD protein complex [GO:0071141]	5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; C2H2 zinc finger domain binding [GO:0070742]; cAMP response element binding [GO:0035497]; DNA binding, bending [GO:0008301]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; MH1 domain binding [GO:0035501]; MH2 domain binding [GO:0035500]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; nucleic acid binding [GO:0003676]; nucleosomal DNA binding [GO:0031492]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]	nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; senescence-associated heterochromatin focus [GO:0035985]; SMAD protein complex [GO:0071141]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; C2H2 zinc finger domain binding [GO:0070742]; cAMP response element binding [GO:0035497]; DNA binding, bending [GO:0008301]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; MH1 domain binding [GO:0035501]; MH2 domain binding [GO:0035500]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; nucleic acid binding [GO:0003676]; nucleosomal DNA binding [GO:0031492]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; base-excision repair [GO:0006284]; cell cycle [GO:0007049]; cell division [GO:0051301]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; chromatin organization [GO:0006325]; chromosome condensation [GO:0030261]; endodermal cell differentiation [GO:0035987]; epithelial to mesenchymal transition [GO:0001837]; fat cell differentiation [GO:0045444]; heterochromatin formation [GO:0031507]; intracellular signal transduction [GO:0035556]; mesenchymal cell differentiation [GO:0048762]; mesodermal cell differentiation [GO:0048333]; mesodermal-endodermal cell signaling [GO:0003131]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oncogene-induced cell senescence [GO:0090402]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle process [GO:0010564]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell population maintenance [GO:2000036]; response to virus [GO:0009615]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Nucleus.
P52945	reviewed	PDX1_HUMAN	Pancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1)	PDX1 IPF1 STF1	Homo sapiens (Human)	283	FUNCTION: Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.	MISCELLANEOUS: According to PubMed:16141209, it may be methylated by SETD7 in vitro. However, the relevance of methylation is unsure in vivo. {ECO:0000269|PubMed:16141209}.	animal organ morphogenesis [GO:0009887]; animal organ regeneration [GO:0031100]; digestive tract development [GO:0048565]; exocrine pancreas development [GO:0031017]; generation of precursor metabolites and energy [GO:0006091]; glucose mediated signaling pathway [GO:0010255]; glucose metabolic process [GO:0006006]; insulin secretion [GO:0030073]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; liver development [GO:0001889]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of insulin secretion [GO:0032024]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; regulation of transcription by RNA polymerase II [GO:0006357]; response to alkaloid [GO:0043279]; response to chlorate [GO:0010157]; response to cytokine [GO:0034097]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to iron(II) ion [GO:0010040]; response to leucine [GO:0043201]; response to nicotine [GO:0035094]; response to vitamin [GO:0033273]; response to xenobiotic stimulus [GO:0009410]; smoothened signaling pathway [GO:0007224]; stem cell differentiation [GO:0048863]; transcription by RNA polymerase II [GO:0006366]; transdifferentiation [GO:0060290]; type B pancreatic cell apoptotic process [GO:0097050]; type B pancreatic cell differentiation [GO:0003309]; type B pancreatic cell proliferation [GO:0044342]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ morphogenesis [GO:0009887]; animal organ regeneration [GO:0031100]; digestive tract development [GO:0048565]; exocrine pancreas development [GO:0031017]; generation of precursor metabolites and energy [GO:0006091]; glucose mediated signaling pathway [GO:0010255]; glucose metabolic process [GO:0006006]; insulin secretion [GO:0030073]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; liver development [GO:0001889]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of insulin secretion [GO:0032024]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; regulation of transcription by RNA polymerase II [GO:0006357]; response to alkaloid [GO:0043279]; response to chlorate [GO:0010157]; response to cytokine [GO:0034097]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to iron(II) ion [GO:0010040]; response to leucine [GO:0043201]; response to nicotine [GO:0035094]; response to vitamin [GO:0033273]; response to xenobiotic stimulus [GO:0009410]; smoothened signaling pathway [GO:0007224]; stem cell differentiation [GO:0048863]; transcription by RNA polymerase II [GO:0006366]; transdifferentiation [GO:0060290]; type B pancreatic cell apoptotic process [GO:0097050]; type B pancreatic cell differentiation [GO:0003309]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytosol {ECO:0000250}.
P52948	reviewed	NUP98_HUMAN	Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)]	NUP98 ADAR2	Homo sapiens (Human)	1817	FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}.		mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606]; proteolysis [GO:0006508]; RNA export from nucleus [GO:0006405]; telomere tethering at nuclear periphery [GO:0034398]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nuclear pore nuclear basket [GO:0044615]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]	mRNA binding [GO:0003729]; nuclear localization sequence binding [GO:0008139]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; serine-type peptidase activity [GO:0008236]; structural constituent of nuclear pore [GO:0017056]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nuclear pore nuclear basket [GO:0044615]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; mRNA binding [GO:0003729]; nuclear localization sequence binding [GO:0008139]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; serine-type peptidase activity [GO:0008236]; structural constituent of nuclear pore [GO:0017056]; transcription coactivator activity [GO:0003713]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606]; proteolysis [GO:0006508]; RNA export from nucleus [GO:0006405]; telomere tethering at nuclear periphery [GO:0034398]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:10087256, ECO:0000269|PubMed:11106761, ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:12191480, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:33360543}; Peripheral membrane protein; Nucleoplasmic side {ECO:0000269|PubMed:11839768}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}. Nucleus, nucleoplasm {ECO:0000269|PubMed:12191480, ECO:0000269|PubMed:28221134}. Note=Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the dissasembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (PubMed:11839768, PubMed:28221134). {ECO:0000269|PubMed:11106761, ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:28221134}.; SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:11106761}. Note=(Microbial infection) Remains localized to the nuclear membrane after poliovirus (PV) infection. {ECO:0000269|PubMed:11106761}.
P52951	reviewed	GBX2_HUMAN	Homeobox protein GBX-2 (Gastrulation and brain-specific homeobox protein 2)	GBX2	Homo sapiens (Human)	348	FUNCTION: May act as a transcription factor for cell pluripotency and differentiation in the embryo.		autonomic nervous system development [GO:0048483]; axon guidance [GO:0007411]; branching involved in blood vessel morphogenesis [GO:0001569]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellum development [GO:0021549]; forebrain neuron development [GO:0021884]; inner ear morphogenesis [GO:0042472]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; regulation of nervous system development [GO:0051960]; regulation of transcription by RNA polymerase II [GO:0006357]; rhombomere 2 development [GO:0021568]; thalamus development [GO:0021794]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; autonomic nervous system development [GO:0048483]; axon guidance [GO:0007411]; branching involved in blood vessel morphogenesis [GO:0001569]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellum development [GO:0021549]; forebrain neuron development [GO:0021884]; inner ear morphogenesis [GO:0042472]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; regulation of nervous system development [GO:0051960]; regulation of transcription by RNA polymerase II [GO:0006357]; rhombomere 2 development [GO:0021568]; thalamus development [GO:0021794]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P52952	reviewed	NKX25_HUMAN	Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)	NKX2-5 CSX NKX2.5 NKX2E	Homo sapiens (Human)	324	FUNCTION: Transcription factor required for the development of the heart and the spleen (PubMed:22560297). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (By similarity). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (PubMed:29899023). {ECO:0000250|UniProtKB:P42582, ECO:0000269|PubMed:22560297, ECO:0000269|PubMed:22849347, ECO:0000269|PubMed:26926761, ECO:0000269|PubMed:29899023}.		adult heart development [GO:0007512]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in heart morphogenesis [GO:0003278]; atrial cardiac muscle cell development [GO:0055014]; atrial cardiac muscle tissue development [GO:0003228]; atrial septum morphogenesis [GO:0060413]; atrioventricular node cell development [GO:0060928]; atrioventricular node cell fate commitment [GO:0060929]; atrioventricular node development [GO:0003162]; bundle of His development [GO:0003166]; cardiac conduction system development [GO:0003161]; cardiac muscle cell development [GO:0055013]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle contraction [GO:0060048]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac septum morphogenesis [GO:0060411]; cardiac ventricle formation [GO:0003211]; cell differentiation [GO:0030154]; embryonic heart tube development [GO:0035050]; embryonic heart tube left/right pattern formation [GO:0060971]; epithelial cell apoptotic process [GO:1904019]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation [GO:0050673]; heart development [GO:0007507]; heart looping [GO:0001947]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; hemopoiesis [GO:0030097]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; pharyngeal system development [GO:0060037]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of heart contraction [GO:0045823]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; proepicardium development [GO:0003342]; pulmonary myocardium development [GO:0003350]; Purkinje myocyte differentiation [GO:0003168]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cardiac muscle contraction [GO:0055117]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; right ventricular cardiac muscle tissue morphogenesis [GO:0003221]; septum secundum development [GO:0003285]; spleen development [GO:0048536]; thyroid gland development [GO:0030878]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570]; ventricular cardiac muscle cell development [GO:0055015]; ventricular cardiac myofibril assembly [GO:0055005]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; Nkx-2.5 complex [GO:1990664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; Nkx-2.5 complex [GO:1990664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; adult heart development [GO:0007512]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in heart morphogenesis [GO:0003278]; atrial cardiac muscle cell development [GO:0055014]; atrial cardiac muscle tissue development [GO:0003228]; atrial septum morphogenesis [GO:0060413]; atrioventricular node cell development [GO:0060928]; atrioventricular node cell fate commitment [GO:0060929]; atrioventricular node development [GO:0003162]; bundle of His development [GO:0003166]; cardiac conduction system development [GO:0003161]; cardiac muscle cell development [GO:0055013]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle contraction [GO:0060048]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac septum morphogenesis [GO:0060411]; cardiac ventricle formation [GO:0003211]; cell differentiation [GO:0030154]; embryonic heart tube development [GO:0035050]; embryonic heart tube left/right pattern formation [GO:0060971]; epithelial cell apoptotic process [GO:1904019]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation [GO:0050673]; heart development [GO:0007507]; heart looping [GO:0001947]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; hemopoiesis [GO:0030097]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; pharyngeal system development [GO:0060037]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of heart contraction [GO:0045823]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; proepicardium development [GO:0003342]; pulmonary myocardium development [GO:0003350]; Purkinje myocyte differentiation [GO:0003168]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cardiac muscle contraction [GO:0055117]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; right ventricular cardiac muscle tissue morphogenesis [GO:0003221]; septum secundum development [GO:0003285]; spleen development [GO:0048536]; thyroid gland development [GO:0030878]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570]; ventricular cardiac muscle cell development [GO:0055015]; ventricular cardiac myofibril assembly [GO:0055005]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29899023}.
P52954	reviewed	LBX1_HUMAN	Transcription factor LBX1 (Ladybird homeobox protein homolog 1)	LBX1 LBX1H	Homo sapiens (Human)	281	FUNCTION: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; cell population proliferation [GO:0008283]; glutamatergic neuron differentiation [GO:1905962]; heart looping [GO:0001947]; muscle organ development [GO:0007517]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of glutamatergic neuron differentiation [GO:0120007]; neuron fate determination [GO:0048664]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord motor neuron differentiation [GO:0021522]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; cell population proliferation [GO:0008283]; glutamatergic neuron differentiation [GO:1905962]; heart looping [GO:0001947]; muscle organ development [GO:0007517]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of glutamatergic neuron differentiation [GO:0120007]; neuron fate determination [GO:0048664]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord motor neuron differentiation [GO:0021522]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P52961	reviewed	NAR1_HUMAN	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 1) (ARTC1) (Mono(ADP-ribosyl)transferase 1) (CD antigen CD296)	ART1	Homo sapiens (Human)	327	FUNCTION: Has ADP-ribosyltransferase activity toward GLP1R. {ECO:0000269|PubMed:21901419}.			cell surface [GO:0009986]; plasma membrane [GO:0005886]; sarcoplasmic reticulum membrane [GO:0033017]; side of membrane [GO:0098552]	NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; sarcoplasmic reticulum membrane [GO:0033017]; side of membrane [GO:0098552]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.
P53004	reviewed	BIEA_HUMAN	Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase)	BLVRA BLVR BVR	Homo sapiens (Human)	296	FUNCTION: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:8631357, PubMed:8424666, PubMed:7929092). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:8631357, PubMed:8424666, PubMed:7929092). NADPH, however, is the probable reactant in biological systems (PubMed:7929092). {ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666, ECO:0000269|PubMed:8631357}.		heme catabolic process [GO:0042167]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	biliberdin reductase NAD+ activity [GO:0106276]; biliverdin reductase (NAD(P)+) activity [GO:0004074]; biliverdin reductase (NADP+) activity [GO:0106277]; nucleotide binding [GO:0000166]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; biliberdin reductase NAD+ activity [GO:0106276]; biliverdin reductase (NAD(P)+) activity [GO:0004074]; biliverdin reductase (NADP+) activity [GO:0106277]; nucleotide binding [GO:0000166]; zinc ion binding [GO:0008270]; heme catabolic process [GO:0042167]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666}.
P53007	reviewed	TXTP_HUMAN	Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Mitochondrial citrate carrier) (CIC) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein)	SLC25A1 SLC20A3	Homo sapiens (Human)	311	FUNCTION: Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate (PubMed:29031613, PubMed:29238895). Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extend cis-aconitate, maleate and succinate (PubMed:29031613). In the cytoplasm citrate is important in the regulation of glycolysis through a feedback mechanism and in the production of acetyl-CoA which is needed for the synthesis of fatty acids, sterols, prostaglandins, dolichol and coenzyme Q (CoQ). Required for proper neuromuscular junction formation (Probable). {ECO:0000269|PubMed:29031613, ECO:0000269|PubMed:29238895, ECO:0000305|PubMed:26870663}.		fatty-acyl-CoA biosynthetic process [GO:0046949]; gluconeogenesis [GO:0006094]; mitochondrial citrate transmembrane transport [GO:0006843]	extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	antiporter activity [GO:0015297]; citrate secondary active transmembrane transporter activity [GO:0071913]; citrate transmembrane transporter activity [GO:0015137]; tricarboxylic acid transmembrane transporter activity [GO:0015142]	extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; antiporter activity [GO:0015297]; citrate secondary active transmembrane transporter activity [GO:0071913]; citrate transmembrane transporter activity [GO:0015137]; tricarboxylic acid transmembrane transporter activity [GO:0015142]; fatty-acyl-CoA biosynthetic process [GO:0046949]; gluconeogenesis [GO:0006094]; mitochondrial citrate transmembrane transport [GO:0006843]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8JZU2}; Multi-pass membrane protein {ECO:0000255}.
P53041	reviewed	PPP5_HUMAN	Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)	PPP5C PPP5	Homo sapiens (Human)	499	FUNCTION: Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (PubMed:14871926, PubMed:16260606, PubMed:21144835). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (PubMed:23102700). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function (By similarity). Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (PubMed:16790549). May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (PubMed:22781750). Dephosphorylates and may play a role in the regulation of TAU/MAPT (PubMed:15546861). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (By similarity). Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (PubMed:30699359). {ECO:0000250|UniProtKB:P53042, ECO:0000250|UniProtKB:Q60676, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15383005, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:19176521, ECO:0000269|PubMed:19948726, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22399290, ECO:0000269|PubMed:22781750, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:9000529}.		DNA-templated transcription [GO:0006351]; double-strand break repair [GO:0006302]; MAPK cascade [GO:0000165]; mitotic cell cycle [GO:0000278]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein dephosphorylation [GO:0006470]; response to arachidonic acid [GO:1904550]; response to lead ion [GO:0010288]; response to morphine [GO:0043278]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]; DNA-templated transcription [GO:0006351]; double-strand break repair [GO:0006302]; MAPK cascade [GO:0000165]; mitotic cell cycle [GO:0000278]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein dephosphorylation [GO:0006470]; response to arachidonic acid [GO:1904550]; response to lead ion [GO:0010288]; response to morphine [GO:0043278]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15383005}. Cytoplasm {ECO:0000269|PubMed:15383005, ECO:0000269|PubMed:19948726}. Cell membrane {ECO:0000269|PubMed:19948726}. Note=Predominantly nuclear (PubMed:15383005). But also present in the cytoplasm (PubMed:15383005). Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner (PubMed:19948726). {ECO:0000269|PubMed:15383005, ECO:0000269|PubMed:19948726}.
P53350	reviewed	PLK1_HUMAN	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)	PLK1 PLK	Homo sapiens (Human)	603	FUNCTION: Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). {ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:8991084}.		centrosome cycle [GO:0007098]; establishment of mitotic spindle orientation [GO:0000132]; establishment of protein localization [GO:0045184]; female meiosis chromosome segregation [GO:0016321]; G2/M transition of mitotic cell cycle [GO:0000086]; Golgi inheritance [GO:0048313]; homologous chromosome segregation [GO:0045143]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; microtubule bundle formation [GO:0001578]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; mitotic cytokinesis [GO:0000281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic nuclear membrane disassembly [GO:0007077]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear membrane disassembly [GO:0051081]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of proteolysis [GO:0045862]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein destabilization [GO:0031648]; protein localization to chromatin [GO:0071168]; protein localization to nuclear envelope [GO:0090435]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of anaphase-promoting complex-dependent catabolic process [GO:1905784]; regulation of cell cycle [GO:0051726]; regulation of cytokinesis [GO:0032465]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic cell cycle phase transition [GO:1901990]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein binding [GO:0043393]; regulation of protein localization to cell cortex [GO:1904776]; sister chromatid cohesion [GO:0007062]; synaptonemal complex disassembly [GO:0070194]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]; synaptonemal complex [GO:0000795]	anaphase-promoting complex binding [GO:0010997]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]; synaptonemal complex [GO:0000795]; anaphase-promoting complex binding [GO:0010997]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; centrosome cycle [GO:0007098]; establishment of mitotic spindle orientation [GO:0000132]; establishment of protein localization [GO:0045184]; female meiosis chromosome segregation [GO:0016321]; G2/M transition of mitotic cell cycle [GO:0000086]; Golgi inheritance [GO:0048313]; homologous chromosome segregation [GO:0045143]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; microtubule bundle formation [GO:0001578]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; mitotic cytokinesis [GO:0000281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic nuclear membrane disassembly [GO:0007077]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear membrane disassembly [GO:0051081]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of proteolysis [GO:0045862]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein destabilization [GO:0031648]; protein localization to chromatin [GO:0071168]; protein localization to nuclear envelope [GO:0090435]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of anaphase-promoting complex-dependent catabolic process [GO:1905784]; regulation of cell cycle [GO:0051726]; regulation of cytokinesis [GO:0032465]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic cell cycle phase transition [GO:1901990]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein binding [GO:0043393]; regulation of protein localization to cell cortex [GO:1904776]; sister chromatid cohesion [GO:0007062]; synaptonemal complex disassembly [GO:0070194]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:24018379}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:30715179}. Midbody {ECO:0000269|PubMed:30715179}. Note=localization at the centrosome starts at the G1/S transition (PubMed:24018379). During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGO1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization. Localizes onto the central spindle by phosphorylating and docking at midzone proteins KIF20A/MKLP2 and PRC1. Colocalizes with FRY to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle. Localization to the centrosome is required for S phase progression (PubMed:24018379). Colocalizes with HSF1 at the spindle poles during prometaphase (PubMed:18794143). {ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:24018379}.
P53355	reviewed	DAPK1_HUMAN	Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)	DAPK1 DAPK	Homo sapiens (Human)	1430	FUNCTION: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.; FUNCTION: Isoform 2 cannot induce apoptosis but can induce membrane blebbing.		apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to hydroperoxide [GO:0071447]; cellular response to type II interferon [GO:0071346]; defense response to tumor cell [GO:0002357]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of translation [GO:0017148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagic cell death [GO:1904094]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of NMDA receptor activity [GO:2000310]; regulation of response to tumor cell [GO:0002834]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; DAPK1-calmodulin complex [GO:1990722]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; syntaxin-1 binding [GO:0017075]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; DAPK1-calmodulin complex [GO:1990722]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; syntaxin-1 binding [GO:0017075]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to hydroperoxide [GO:0071447]; cellular response to type II interferon [GO:0071346]; defense response to tumor cell [GO:0002357]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of translation [GO:0017148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagic cell death [GO:1904094]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of NMDA receptor activity [GO:2000310]; regulation of response to tumor cell [GO:0002834]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with MAP1B in the microtubules and cortical actin fibers.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton.
P53365	reviewed	ARFP2_HUMAN	Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (POR1)	ARFIP2 POR1	Homo sapiens (Human)	341	FUNCTION: Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network (PubMed:26507660). May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site (PubMed:31204568, PubMed:30917996). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658). {ECO:0000269|PubMed:26296658, ECO:0000269|PubMed:26507660, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:31204568, ECO:0000269|PubMed:33773106}.		actin cytoskeleton organization [GO:0030036]; intracellular protein transport [GO:0006886]; lamellipodium assembly [GO:0030032]; mitophagy [GO:0000423]; protein localization to phagophore assembly site [GO:0034497]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; small GTPase mediated signal transduction [GO:0007264]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; trans-Golgi network membrane [GO:0032588]	cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; identical protein binding [GO:0042802]; membrane curvature sensor activity [GO:0140090]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; small GTPase binding [GO:0031267]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; trans-Golgi network membrane [GO:0032588]; cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; identical protein binding [GO:0042802]; membrane curvature sensor activity [GO:0140090]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; intracellular protein transport [GO:0006886]; lamellipodium assembly [GO:0030032]; mitophagy [GO:0000423]; protein localization to phagophore assembly site [GO:0034497]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:22981988}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21239483, ECO:0000269|PubMed:22679020, ECO:0000269|PubMed:26507660, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:31204568}.
P53367	reviewed	ARFP1_HUMAN	Arfaptin-1 (ADP-ribosylation factor-interacting protein 1)	ARFIP1	Homo sapiens (Human)	373	FUNCTION: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:9038142, PubMed:22981988). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}.		intracellular protein transport [GO:0006886]; negative regulation of retrograde transport, endosome to Golgi [GO:1905280]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of protein secretion [GO:0050708]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network membrane [GO:0032588]	phosphatidylinositol-4-phosphate binding [GO:0070273]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network membrane [GO:0032588]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; intracellular protein transport [GO:0006886]; negative regulation of retrograde transport, endosome to Golgi [GO:1905280]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of protein secretion [GO:0050708]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21239483, ECO:0000269|PubMed:30917996}.
P53370	reviewed	NUDT6_HUMAN	Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (EC 3.6.1.-) (Antisense basic fibroblast growth factor) (Protein GFG)	NUDT6 FGF2AS	Homo sapiens (Human)	316	FUNCTION: May contribute to the regulation of cell proliferation. {ECO:0000269|PubMed:11266510}.	MISCELLANEOUS: This protein is coded from a FGF2 (BFGF) gene antisense transcript.	negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	ADP-ribose diphosphatase activity [GO:0047631]; NAD binding [GO:0051287]; NADH pyrophosphatase activity [GO:0035529]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ADP-ribose diphosphatase activity [GO:0047631]; NAD binding [GO:0051287]; NADH pyrophosphatase activity [GO:0035529]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms.
P53384	reviewed	NUBP1_HUMAN	Cytosolic Fe-S cluster assembly factor NUBP1 (Nucleotide-binding protein 1) (NBP 1)	NUBP1 NBP NBP1	Homo sapiens (Human)	320	FUNCTION: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874). Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874). The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication (By similarity). Negatively regulates cilium formation and structure (By similarity). {ECO:0000250|UniProtKB:Q9R060, ECO:0000269|PubMed:18573874}.		cell projection organization [GO:0030030]; centrosome localization [GO:0051642]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of centrosome duplication [GO:0010826]; protein localization to cell cortex [GO:0072697]; regulation of cell growth [GO:0001558]	centriole [GO:0005814]; cilium [GO:0005929]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent FeS chaperone activity [GO:0140663]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]	centriole [GO:0005814]; cilium [GO:0005929]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent FeS chaperone activity [GO:0140663]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; cell projection organization [GO:0030030]; centrosome localization [GO:0051642]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of centrosome duplication [GO:0010826]; protein localization to cell cortex [GO:0072697]; regulation of cell growth [GO:0001558]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03038, ECO:0000269|PubMed:18573874, ECO:0000269|PubMed:29848660}. Nucleus {ECO:0000250|UniProtKB:Q9R060}. Cell projection {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis. Localized at centrioles and in the nucleus at interphase. Colocalizes with nubp-2 at prometaphase. Specifically localizes to the axenome of motile cilia as opposed to primary non-motile cilia. Localization is independent of NUBP2 and KIFC1. {ECO:0000250|UniProtKB:Q9R060}.
P53396	reviewed	ACLY_HUMAN	ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme)	ACLY	Homo sapiens (Human)	1101	FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:9116495}.		acetyl-CoA biosynthetic process [GO:0006085]; cholesterol biosynthetic process [GO:0006695]; citrate metabolic process [GO:0006101]; coenzyme A metabolic process [GO:0015936]; fatty acid biosynthetic process [GO:0006633]; lipid biosynthetic process [GO:0008610]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; ATP citrate synthase activity [GO:0003878]; metal ion binding [GO:0046872]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ATP citrate synthase activity [GO:0003878]; metal ion binding [GO:0046872]; acetyl-CoA biosynthetic process [GO:0006085]; cholesterol biosynthetic process [GO:0006695]; citrate metabolic process [GO:0006101]; coenzyme A metabolic process [GO:0015936]; fatty acid biosynthetic process [GO:0006633]; lipid biosynthetic process [GO:0008610]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:9116495}.
P53420	reviewed	CO4A4_HUMAN	Collagen alpha-4(IV) chain	COL4A4	Homo sapiens (Human)	1690	FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.		glomerular basement membrane development [GO:0032836]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; molecular adaptor activity [GO:0060090]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; molecular adaptor activity [GO:0060090]; glomerular basement membrane development [GO:0032836]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000255|PROSITE-ProRule:PRU00736}. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). {ECO:0000250}.
P53539	reviewed	FOSB_HUMAN	Protein FosB (FosB proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 3) (Transcription factor AP-1 subunit FosB)	FOSB G0S3	Homo sapiens (Human)	338	FUNCTION: Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity (PubMed:12618758, PubMed:28981703). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Exhibits transactivation activity in vitro (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity). {ECO:0000250|UniProtKB:P13346, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:28981703}.; FUNCTION: [Isoform 11]: Exhibits lower transactivation activity than isoform 1 in vitro (By similarity). The heterodimer with JUN does not display any transcriptional activity, and may thereby act as an transcriptional inhibitor (By similarity). May be involved in the regulation of neurogenesis in the hippocampus (By similarity). May play a role in synaptic modifications in nucleus accumbens medium spiny neurons and thereby play a role in adaptive and pathological reward-dependent learning, including maladaptive responses involved in drug addiction (By similarity). Seems to be more stably expressed with a half-life of ~9.5 hours in cell culture as compared to 1.5 hours half-life of isoform 1 (By similarity). {ECO:0000250|UniProtKB:P13346}.		cellular response to calcium ion [GO:0071277]; cellular response to hormone stimulus [GO:0032870]; female pregnancy [GO:0007565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to corticosterone [GO:0051412]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to calcium ion [GO:0071277]; cellular response to hormone stimulus [GO:0032870]; female pregnancy [GO:0007565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to corticosterone [GO:0051412]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P13346}.
P53567	reviewed	CEBPG_HUMAN	CCAAT/enhancer-binding protein gamma (C/EBP gamma)	CEBPG	Homo sapiens (Human)	150	FUNCTION: Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. {ECO:0000250|UniProtKB:P26801, ECO:0000250|UniProtKB:P53568, ECO:0000269|PubMed:7665092}.		B cell differentiation [GO:0030183]; DNA-templated transcription [GO:0006351]; enucleate erythrocyte differentiation [GO:0043353]; immune response [GO:0006955]; integrated stress response signaling [GO:0140467]; liver development [GO:0001889]; mRNA metabolic process [GO:0016071]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; B cell differentiation [GO:0030183]; DNA-templated transcription [GO:0006351]; enucleate erythrocyte differentiation [GO:0043353]; immune response [GO:0006955]; integrated stress response signaling [GO:0140467]; liver development [GO:0001889]; mRNA metabolic process [GO:0016071]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53568}.
P53582	reviewed	MAP11_HUMAN	Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1)	METAP1 KIAA0094	Homo sapiens (Human)	386	FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. {ECO:0000269|PubMed:16274222, ECO:0000269|PubMed:17114291}.		N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; platelet aggregation [GO:0070527]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of translation [GO:0006417]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	aminopeptidase activity [GO:0004177]; initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; aminopeptidase activity [GO:0004177]; initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; platelet aggregation [GO:0070527]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of translation [GO:0006417]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03174}.
P53597	reviewed	SUCA_HUMAN	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)	SUCLG1	Homo sapiens (Human)	346	FUNCTION: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. {ECO:0000255|HAMAP-Rule:MF_03222}.		succinyl-CoA catabolic process [GO:1901289]; tricarboxylic acid cycle [GO:0006099]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; succinate-CoA ligase complex (ADP-forming) [GO:0009361]; succinate-CoA ligase complex (GDP-forming) [GO:0045244]	nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinate-CoA ligase (GDP-forming) activity [GO:0004776]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; succinate-CoA ligase complex (ADP-forming) [GO:0009361]; succinate-CoA ligase complex (GDP-forming) [GO:0045244]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinate-CoA ligase (GDP-forming) activity [GO:0004776]; succinyl-CoA catabolic process [GO:1901289]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03222}.
P53602	reviewed	MVD1_HUMAN	Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase)	MVD MPD	Homo sapiens (Human)	400	FUNCTION: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. {ECO:0000269|PubMed:18823933, ECO:0000269|PubMed:8626466, ECO:0000269|PubMed:9392419}.		cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; isoprenoid biosynthetic process [GO:0008299]; positive regulation of cell population proliferation [GO:0008284]	cytosol [GO:0005829]	ATP binding [GO:0005524]; diphosphomevalonate decarboxylase activity [GO:0004163]; Hsp70 protein binding [GO:0030544]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; ATP binding [GO:0005524]; diphosphomevalonate decarboxylase activity [GO:0004163]; Hsp70 protein binding [GO:0030544]; protein homodimerization activity [GO:0042803]; cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; isoprenoid biosynthetic process [GO:0008299]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14972328}.
P53609	reviewed	PGTB1_HUMAN	Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta)	PGGT1B	Homo sapiens (Human)	377	FUNCTION: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B. {ECO:0000269|PubMed:8106351}.		protein geranylgeranylation [GO:0018344]	CAAX-protein geranylgeranyltransferase complex [GO:0005953]	CAAX-protein geranylgeranyltransferase activity [GO:0004662]; protein geranylgeranyltransferase activity [GO:0004661]; zinc ion binding [GO:0008270]	CAAX-protein geranylgeranyltransferase complex [GO:0005953]; CAAX-protein geranylgeranyltransferase activity [GO:0004662]; protein geranylgeranyltransferase activity [GO:0004661]; zinc ion binding [GO:0008270]; protein geranylgeranylation [GO:0018344]	
P53611	reviewed	PGTB2_HUMAN	Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta)	RABGGTB GGTB	Homo sapiens (Human)	331	FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. {ECO:0000269|PubMed:7991565}.		protein geranylgeranylation [GO:0018344]; protein modification process [GO:0036211]; visual perception [GO:0007601]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; Rab-protein geranylgeranyltransferase complex [GO:0005968]	Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; Rab-protein geranylgeranyltransferase complex [GO:0005968]; Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]; protein geranylgeranylation [GO:0018344]; protein modification process [GO:0036211]; visual perception [GO:0007601]	
P53618	reviewed	COPB_HUMAN	Coatomer subunit beta (Beta-coat protein) (Beta-COP)	COPB1 COPB MSTP026	Homo sapiens (Human)	953	FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments. {ECO:0000250, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:18725938, ECO:0000269|PubMed:19364919, ECO:0000269|PubMed:20056612}.	MISCELLANEOUS: Brefeldin A induces dissociation from the Golgi of the beta-COP and presumably the other coatomer subunits.	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; ficolin-1-rich granule membrane [GO:0101003]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]; transport vesicle [GO:0030133]	structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; ficolin-1-rich granule membrane [GO:0101003]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]; transport vesicle [GO:0030133]; structural molecule activity [GO:0005198]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane {ECO:0000269|PubMed:11056392, ECO:0000269|PubMed:17451557, ECO:0000269|PubMed:7573041}; Peripheral membrane protein {ECO:0000269|PubMed:17451557, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:20056612}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:20362547}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:Q9JIF7}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Proteolytic cleavage by CAPN8 triggers translocation from Golgi to cytoplasm (By similarity). Found in perinuclear vesicular-tubular clusters (VTCs) and in the Golgi region where associated with vesicles, buds and rims of the Golgi stack (By similarity). Occasionally present at the trans-side of Golgi, but mainly present at the cis-Golgi side in transitional areas (TA), on so-called peripheral elements (PE) consisting of tubules and vesicles located between the cup-shaped transitional elements (TE) of the rough endoplasmic reticulum (RER) and the cis-most Golgi cisternae (By similarity). Present in cytoplasm, not associated with visible coats or membranes, with a minor fraction present on small clusters of tubules and vesicles (By similarity). Some association with high-density and low-density microsomes and mitochondria/nuclei fraction (By similarity). Very little found in plasma membrane fraction (PubMed:20362547). {ECO:0000250|UniProtKB:P23514, ECO:0000269|PubMed:20362547}.
P53621	reviewed	COPA_HUMAN	Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]	COPA	Homo sapiens (Human)	1224	FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; pancreatic juice secretion [GO:0030157]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	COPI vesicle coat [GO:0030126]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; membrane [GO:0016020]; transport vesicle [GO:0030133]	hormone activity [GO:0005179]; structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; membrane [GO:0016020]; transport vesicle [GO:0030133]; hormone activity [GO:0005179]; structural molecule activity [GO:0005198]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; pancreatic juice secretion [GO:0030157]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.; SUBCELLULAR LOCATION: [Xenin]: Secreted {ECO:0000250}.
P53634	reviewed	CATC_HUMAN	Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)]	CTSC CPPI	Homo sapiens (Human)	463	FUNCTION: Thiol protease (PubMed:1586157). Has dipeptidylpeptidase activity (PubMed:1586157). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:1586157). Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1586157). Can act as both an exopeptidase and endopeptidase (PubMed:1586157). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (PubMed:8428921). {ECO:0000269|PubMed:1586157, ECO:0000269|PubMed:8428921}.		immune response [GO:0006955]; negative regulation of myelination [GO:0031642]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to organic substance [GO:0010033]; T cell mediated cytotoxicity [GO:0001913]	azurophil granule lumen [GO:0035578]; centrosome [GO:0005813]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	chloride ion binding [GO:0031404]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; peptidase activator activity involved in apoptotic process [GO:0016505]; phosphatase binding [GO:0019902]; protein self-association [GO:0043621]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252]	azurophil granule lumen [GO:0035578]; centrosome [GO:0005813]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; chloride ion binding [GO:0031404]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; peptidase activator activity involved in apoptotic process [GO:0016505]; phosphatase binding [GO:0019902]; protein self-association [GO:0043621]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252]; immune response [GO:0006955]; negative regulation of myelination [GO:0031642]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to organic substance [GO:0010033]; T cell mediated cytotoxicity [GO:0001913]	SUBCELLULAR LOCATION: Lysosome {ECO:0000305|PubMed:7665576}.
P53667	reviewed	LIMK1_HUMAN	LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1)	LIMK1 LIMK	Homo sapiens (Human)	647	FUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:16230460, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23633677}.; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269|PubMed:10196227}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; axon extension [GO:0048675]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; nervous system development [GO:0007399]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of axon extension [GO:0045773]; positive regulation of stress fiber assembly [GO:0051496]; protein phosphorylation [GO:0006468]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; stress fiber assembly [GO:0043149]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; actin cytoskeleton organization [GO:0030036]; axon extension [GO:0048675]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; nervous system development [GO:0007399]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of axon extension [GO:0045773]; positive regulation of stress fiber assembly [GO:0051496]; protein phosphorylation [GO:0006468]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; stress fiber assembly [GO:0043149]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21682918}. Nucleus {ECO:0000269|PubMed:21682918}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10196227, ECO:0000269|PubMed:16230460}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P53668}. Note=Predominantly found in the cytoplasm. Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner. {ECO:0000250|UniProtKB:P53668}.
P53671	reviewed	LIMK2_HUMAN	LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1)	LIMK2	Homo sapiens (Human)	638	FUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:8537403}.		actin cytoskeleton organization [GO:0030036]; astral microtubule organization [GO:0030953]; cornea development in camera-type eye [GO:0061303]; establishment of vesicle localization [GO:0051650]; head development [GO:0060322]; negative regulation of cilium assembly [GO:1902018]; phosphorylation [GO:0016310]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283]	centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; actin cytoskeleton organization [GO:0030036]; astral microtubule organization [GO:0030953]; cornea development in camera-type eye [GO:0061303]; establishment of vesicle localization [GO:0051650]; head development [GO:0060322]; negative regulation of cilium assembly [GO:1902018]; phosphorylation [GO:0016310]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:22328514}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25849865}.; SUBCELLULAR LOCATION: [Isoform LIMK2a]: Cytoplasm {ECO:0000269|PubMed:8954941}. Nucleus {ECO:0000269|PubMed:8954941}.; SUBCELLULAR LOCATION: [Isoform LIMK2b]: Cytoplasm {ECO:0000269|PubMed:8954941}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:8954941}. Nucleus {ECO:0000269|PubMed:8954941}. Note=Mainly present in the cytoplasm and is scarcely translocated to the nucleus. {ECO:0000269|PubMed:8954941}.
P53672	reviewed	CRBA2_HUMAN	Beta-crystallin A2 (Beta-A2 crystallin)	CRYBA2	Homo sapiens (Human)	197	FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.		lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]		identical protein binding [GO:0042802]; structural constituent of eye lens [GO:0005212]	identical protein binding [GO:0042802]; structural constituent of eye lens [GO:0005212]; lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]	
P53673	reviewed	CRBA4_HUMAN	Beta-crystallin A4 (Beta-A4 crystallin)	CRYBA4	Homo sapiens (Human)	196	FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.		camera-type eye development [GO:0043010]; lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]		identical protein binding [GO:0042802]; structural constituent of eye lens [GO:0005212]	identical protein binding [GO:0042802]; structural constituent of eye lens [GO:0005212]; camera-type eye development [GO:0043010]; lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]	
P53674	reviewed	CRBB1_HUMAN	Beta-crystallin B1 (Beta-B1 crystallin)	CRYBB1	Homo sapiens (Human)	252	FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.		lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]		structural constituent of eye lens [GO:0005212]	structural constituent of eye lens [GO:0005212]; lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]	
P53675	reviewed	CLH2_HUMAN	Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22)	CLTCL1 CLH22 CLTCL CLTD	Homo sapiens (Human)	1640	FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; positive regulation of glucose import [GO:0046326]; receptor-mediated endocytosis [GO:0006898]; retrograde transport, endosome to Golgi [GO:0042147]	clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; coated vesicle [GO:0030135]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; membrane [GO:0016020]; sorting endosome [GO:0097443]; spindle [GO:0005819]; trans-Golgi network [GO:0005802]	clathrin light chain binding [GO:0032051]; structural molecule activity [GO:0005198]	clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; coated vesicle [GO:0030135]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; membrane [GO:0016020]; sorting endosome [GO:0097443]; spindle [GO:0005819]; trans-Golgi network [GO:0005802]; clathrin light chain binding [GO:0032051]; structural molecule activity [GO:0005198]; anatomical structure morphogenesis [GO:0009653]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; positive regulation of glucose import [GO:0046326]; receptor-mediated endocytosis [GO:0006898]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Cytoplasmic face of coated pits and vesicles. {ECO:0000250}.
P53677	reviewed	AP3M2_HUMAN	AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B)	AP3M2	Homo sapiens (Human)	418	FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.		anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]	AP-3 adaptor complex [GO:0030123]; AP-type membrane coat adaptor complex [GO:0030119]; axon cytoplasm [GO:1904115]; clathrin adaptor complex [GO:0030131]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; presynapse [GO:0098793]		AP-3 adaptor complex [GO:0030123]; AP-type membrane coat adaptor complex [GO:0030119]; axon cytoplasm [GO:1904115]; clathrin adaptor complex [GO:0030131]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; presynapse [GO:0098793]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
P53680	reviewed	AP2S1_HUMAN	AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)	AP2S1 AP17 CLAPS2	Homo sapiens (Human)	142	FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis. {ECO:0000250, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23222959}.		clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; regulation of endocytosis [GO:0030100]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192]	AP-2 adaptor complex [GO:0030122]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]	clathrin adaptor activity [GO:0035615]	AP-2 adaptor complex [GO:0030122]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; clathrin adaptor activity [GO:0035615]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; regulation of endocytosis [GO:0030100]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P63010}. Membrane, coated pit {ECO:0000269|PubMed:33859415}; Peripheral membrane protein {ECO:0000305|PubMed:33859415}; Cytoplasmic side {ECO:0000305|PubMed:33859415}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250|UniProtKB:P63010}.
P53701	reviewed	CCHL_HUMAN	Holocytochrome c-type synthase (EC 4.4.1.17) (Cytochrome c-type heme lyase)	HCCS CCHL	Homo sapiens (Human)	268	FUNCTION: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome. {ECO:0000269|PubMed:23150584}.		animal organ morphogenesis [GO:0009887]; cytochrome c-heme linkage [GO:0018063]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	heme binding [GO:0020037]; holocytochrome-c synthase activity [GO:0004408]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; heme binding [GO:0020037]; holocytochrome-c synthase activity [GO:0004408]; metal ion binding [GO:0046872]; animal organ morphogenesis [GO:0009887]; cytochrome c-heme linkage [GO:0018063]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:17033964}. Membrane {ECO:0000269|PubMed:23150584}; Lipid-anchor {ECO:0000305|PubMed:25255805, ECO:0000305|PubMed:25807930}.
P53708	reviewed	ITA8_HUMAN	Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]	ITGA8	Homo sapiens (Human)	1063	FUNCTION: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. {ECO:0000269|PubMed:12415008, ECO:0000269|PubMed:15721307}.		cell adhesion mediated by integrin [GO:0033627]; cell projection organization [GO:0030030]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; establishment of protein localization [GO:0045184]; extracellular matrix organization [GO:0030198]; inner ear morphogenesis [GO:0042472]; integrin-mediated signaling pathway [GO:0007229]; kidney development [GO:0001822]; memory [GO:0007613]; mesodermal cell differentiation [GO:0048333]; metanephros development [GO:0001656]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; smooth muscle cell differentiation [GO:0051145]; smooth muscle tissue development [GO:0048745]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]	apical part of cell [GO:0045177]; cell surface [GO:0009986]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; integrin alpha8-beta1 complex [GO:0034678]; integrin complex [GO:0008305]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	integrin binding [GO:0005178]; metal ion binding [GO:0046872]	apical part of cell [GO:0045177]; cell surface [GO:0009986]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; integrin alpha8-beta1 complex [GO:0034678]; integrin complex [GO:0008305]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; cell adhesion mediated by integrin [GO:0033627]; cell projection organization [GO:0030030]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; establishment of protein localization [GO:0045184]; extracellular matrix organization [GO:0030198]; inner ear morphogenesis [GO:0042472]; integrin-mediated signaling pathway [GO:0007229]; kidney development [GO:0001822]; memory [GO:0007613]; mesodermal cell differentiation [GO:0048333]; metanephros development [GO:0001656]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; smooth muscle cell differentiation [GO:0051145]; smooth muscle tissue development [GO:0048745]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24439109}; Single-pass type I membrane protein {ECO:0000269|PubMed:24439109}. Cell membrane {ECO:0000269|PubMed:24439109}.
P53778	reviewed	MK12_HUMAN	Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)	MAPK12 ERK6 SAPK3	Homo sapiens (Human)	367	FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. {ECO:0000269|PubMed:10848581, ECO:0000269|PubMed:14592936, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:21172807, ECO:0000269|PubMed:8633070, ECO:0000269|PubMed:9430721}.		cell cycle [GO:0007049]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; muscle organ development [GO:0007517]; myoblast differentiation [GO:0045445]; negative regulation of cell cycle [GO:0045786]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of peptidase activity [GO:0010952]; regulation of cell cycle [GO:0051726]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell cycle [GO:0007049]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; muscle organ development [GO:0007517]; myoblast differentiation [GO:0045445]; negative regulation of cell cycle [GO:0045786]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of peptidase activity [GO:0010952]; regulation of cell cycle [GO:0051726]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). {ECO:0000250}.
P53779	reviewed	MK10_HUMAN	Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)	MAPK10 JNK3 JNK3A PRKM10 SAPK1B	Homo sapiens (Human)	464	FUNCTION: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). {ECO:0000269|PubMed:11718727, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692}.		cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; response to light stimulus [GO:0009416]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; MAP kinase kinase activity [GO:0004708]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; MAP kinase kinase activity [GO:0004708]; protein serine kinase activity [GO:0106310]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; response to light stimulus [GO:0009416]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16737965}. Membrane {ECO:0000269|PubMed:16737965}; Lipid-anchor {ECO:0000269|PubMed:16737965}. Nucleus {ECO:0000269|PubMed:16737965}. Mitochondrion {ECO:0000269|PubMed:16737965}. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). {ECO:0000250}.
P53794	reviewed	SC5A3_HUMAN	Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3)	SLC5A3	Homo sapiens (Human)	718	FUNCTION: Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (PubMed:24595108, PubMed:28793216). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (PubMed:24595108) (By similarity). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (PubMed:28793216). Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (PubMed:27217553). {ECO:0000250|UniProtKB:P31637, ECO:0000250|UniProtKB:Q9JKZ2, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:27217553, ECO:0000269|PubMed:28793216}.		fucose transmembrane transport [GO:0015756]; glucose transmembrane transport [GO:1904659]; inositol metabolic process [GO:0006020]; myo-inositol import across plasma membrane [GO:1904679]; myo-inositol transport [GO:0015798]; pentose transmembrane transport [GO:0015750]; peripheral nervous system development [GO:0007422]; polyol transmembrane transport [GO:0015791]; positive regulation of catalytic activity [GO:0043085]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; regulation of respiratory gaseous exchange [GO:0043576]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	fucose transmembrane transporter activity [GO:0015150]; glucose:sodium symporter activity [GO:0005412]; myo-inositol transmembrane transporter activity [GO:0005365]; myo-inositol:sodium symporter activity [GO:0005367]; pentose transmembrane transporter activity [GO:0015146]; polyol transmembrane transporter activity [GO:0015166]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; fucose transmembrane transporter activity [GO:0015150]; glucose:sodium symporter activity [GO:0005412]; myo-inositol transmembrane transporter activity [GO:0005365]; myo-inositol:sodium symporter activity [GO:0005367]; pentose transmembrane transporter activity [GO:0015146]; polyol transmembrane transporter activity [GO:0015166]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; fucose transmembrane transport [GO:0015756]; glucose transmembrane transport [GO:1904659]; inositol metabolic process [GO:0006020]; myo-inositol import across plasma membrane [GO:1904679]; myo-inositol transport [GO:0015798]; pentose transmembrane transport [GO:0015750]; peripheral nervous system development [GO:0007422]; polyol transmembrane transport [GO:0015791]; positive regulation of catalytic activity [GO:0043085]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; regulation of respiratory gaseous exchange [GO:0043576]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9JKZ2}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9JKZ2}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with KCNQ1 at the apical membrane of choroid plexus epithelium. {ECO:0000250|UniProtKB:Q9JKZ2}.
P53801	reviewed	PTTG_HUMAN	Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor)	PTTG1IP C21orf1 C21orf3	Homo sapiens (Human)	180	FUNCTION: May facilitate PTTG1 nuclear translocation.		negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of protein ubiquitination [GO:0031398]; protein import into nucleus [GO:0006606]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	p53 binding [GO:0002039]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; p53 binding [GO:0002039]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of protein ubiquitination [GO:0031398]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:10781616}. Nucleus {ECO:0000269|PubMed:10781616}. Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus.
P53803	reviewed	RPAB4_HUMAN	DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (ABC10-alpha) (DNA-directed RNA polymerase II subunit K) (RNA polymerase II 7.0 kDa subunit) (RPB7.0) (RPB10alpha)	POLR2K	Homo sapiens (Human)	58	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.		regulation of transcription by RNA polymerase I [GO:0006356]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; zinc ion binding [GO:0008270]; regulation of transcription by RNA polymerase I [GO:0006356]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P53804	reviewed	TTC3_HUMAN	E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)	TTC3 DCRR1 RNF105 TPRD	Homo sapiens (Human)	2025	FUNCTION: E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323). {ECO:0000269|PubMed:17488780, ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:24695496, ECO:0000269|PubMed:30203323, ECO:0000269|PubMed:30696809}.		protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:30203323}. Cytoplasm {ECO:0000269|PubMed:30203323}. Golgi apparatus {ECO:0000250|UniProtKB:D3ZSP7}. Note=Nuclear localization may be dependent on the proteolytic cleavage of full length protein in the cytoplasm (PubMed:30203323). This cleavage may reveal an N-terminal nuclear localization signal, allowing N-terminal fragments to enter the nucleus (PubMed:30203323). {ECO:0000269|PubMed:30203323}.
P53805	reviewed	RCAN1_HUMAN	Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1)	RCAN1 ADAPT78 CSP1 DSC1 DSCR1	Homo sapiens (Human)	252	FUNCTION: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). {ECO:0000250|UniProtKB:Q9JHG6, ECO:0000269|PubMed:12809556}.		calcineurin-NFAT signaling cascade [GO:0033173]; calcium-mediated signaling [GO:0019722]; locomotion involved in locomotory behavior [GO:0031987]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; response to ischemia [GO:0002931]; response to oxidative stress [GO:0006979]; short-term memory [GO:0007614]; skeletal muscle fiber development [GO:0048741]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; calcineurin-NFAT signaling cascade [GO:0033173]; calcium-mediated signaling [GO:0019722]; locomotion involved in locomotory behavior [GO:0031987]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; response to ischemia [GO:0002931]; response to oxidative stress [GO:0006979]; short-term memory [GO:0007614]; skeletal muscle fiber development [GO:0048741]	
P53814	reviewed	SMTN_HUMAN	Smoothelin	SMTN SMSMO	Homo sapiens (Human)	917	FUNCTION: Structural protein of the cytoskeleton.	MISCELLANEOUS: [Isoform A]: Produced by alternative promoter usage. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; muscle organ development [GO:0007517]; smooth muscle contraction [GO:0006939]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815]	actin binding [GO:0003779]; structural constituent of muscle [GO:0008307]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815]; actin binding [GO:0003779]; structural constituent of muscle [GO:0008307]; actin cytoskeleton organization [GO:0030036]; muscle organ development [GO:0007517]; smooth muscle contraction [GO:0006939]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Exhibits a filamentous organization.
P53816	reviewed	PLAT3_HUMAN	Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) (H-REV107) (HREV107-1) (HRAS-like suppressor 1) (HRAS-like suppressor 3) (HRSL3) (HREV107-3) (Renal carcinoma antigen NY-REN-65)	PLAAT3 HRASLS3 HREV107 PLA2G16	Homo sapiens (Human)	162	FUNCTION: Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852). Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity (By similarity). {ECO:0000250|UniProtKB:Q8R3U1, ECO:0000269|PubMed:19047760, ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:22605381, ECO:0000269|PubMed:22825852, ECO:0000269|PubMed:22923616, ECO:0000303|PubMed:26503625}.; FUNCTION: (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PubMed:28077878). May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection (PubMed:28077878). Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome (PubMed:28077878). May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery (PubMed:28077878). The lipid-modifying enzyme activity is required for this process (PubMed:28077878). {ECO:0000269|PubMed:28077878}.		ether lipid metabolic process [GO:0046485]; lens fiber cell differentiation [GO:0070306]; lipid catabolic process [GO:0016042]; localization [GO:0051179]; membrane disassembly [GO:0030397]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; organelle disassembly [GO:1903008]; peroxisome organization [GO:0007031]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phospholipid biosynthetic process [GO:0008654]; phospholipid metabolic process [GO:0006644]; regulation of adipose tissue development [GO:1904177]; response to bacterium [GO:0009617]; triglyceride metabolic process [GO:0006641]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]	1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; acyltransferase activity [GO:0016746]; lipid binding [GO:0008289]; N-acyltransferase activity [GO:0016410]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; acyltransferase activity [GO:0016746]; lipid binding [GO:0008289]; N-acyltransferase activity [GO:0016410]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]; ether lipid metabolic process [GO:0046485]; lens fiber cell differentiation [GO:0070306]; lipid catabolic process [GO:0016042]; localization [GO:0051179]; membrane disassembly [GO:0030397]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; organelle disassembly [GO:1903008]; peroxisome organization [GO:0007031]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phospholipid biosynthetic process [GO:0008654]; phospholipid metabolic process [GO:0006644]; regulation of adipose tissue development [GO:1904177]; response to bacterium [GO:0009617]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P53817}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:17374643}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8R3U1}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8R3U1}. Peroxisome membrane {ECO:0000250|UniProtKB:Q8R3U1}; Single-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q8R3U1}; Single-pass membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000250|UniProtKB:Q8R3U1}. Lysosome membrane {ECO:0000250|UniProtKB:Q8R3U1}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R3U1}; Single-pass membrane protein {ECO:0000305}. Note=During eye lens differentiation, recruited from the cytosol to various organelles, including mitochondria, endoplasmic reticulum, nuclear envelope and lysosomes, immediately before organelle degradation. This translocation is triggered by organelle membrane damage and requires the C-terminal transmembrane domain. {ECO:0000250|UniProtKB:Q8R3U1}.
P53985	reviewed	MOT1_HUMAN	Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1)	SLC16A1 MCT1	Homo sapiens (Human)	500	FUNCTION: Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:33333023, PubMed:32946811). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811). Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023). {ECO:0000250|UniProtKB:P53986, ECO:0000250|UniProtKB:P53987, ECO:0000269|PubMed:12946269, ECO:0000269|PubMed:32946811, ECO:0000269|PubMed:33333023}.	MISCELLANEOUS: Overexpression in pancreatic beta-cells triggers insulin secretion in response to pyruvate, causing hyperinsulemia and hypoglycemia during strenuous exercise.	behavioral response to nutrient [GO:0051780]; carboxylic acid transmembrane transport [GO:1905039]; cellular response to organic cyclic compound [GO:0071407]; centrosome cycle [GO:0007098]; glucose homeostasis [GO:0042593]; lipid metabolic process [GO:0006629]; mevalonate transport [GO:0015728]; monocarboxylic acid transport [GO:0015718]; plasma membrane lactate transport [GO:0035879]; pyruvate catabolic process [GO:0042867]; pyruvate transmembrane transport [GO:1901475]; regulation of insulin secretion [GO:0050796]; response to food [GO:0032094]; succinate transmembrane transport [GO:0071422]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; centrosome [GO:0005813]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	carboxylic acid transmembrane transporter activity [GO:0046943]; identical protein binding [GO:0042802]; lactate transmembrane transporter activity [GO:0015129]; lactate:proton symporter activity [GO:0015650]; mevalonate transmembrane transporter activity [GO:0015130]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; organic cyclic compound binding [GO:0097159]; succinate transmembrane transporter activity [GO:0015141]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; centrosome [GO:0005813]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; carboxylic acid transmembrane transporter activity [GO:0046943]; identical protein binding [GO:0042802]; lactate transmembrane transporter activity [GO:0015129]; lactate:proton symporter activity [GO:0015650]; mevalonate transmembrane transporter activity [GO:0015130]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; organic cyclic compound binding [GO:0097159]; succinate transmembrane transporter activity [GO:0015141]; behavioral response to nutrient [GO:0051780]; carboxylic acid transmembrane transport [GO:1905039]; cellular response to organic cyclic compound [GO:0071407]; centrosome cycle [GO:0007098]; glucose homeostasis [GO:0042593]; lipid metabolic process [GO:0006629]; mevalonate transport [GO:0015728]; monocarboxylic acid transport [GO:0015718]; plasma membrane lactate transport [GO:0035879]; pyruvate catabolic process [GO:0042867]; pyruvate transmembrane transport [GO:1901475]; regulation of insulin secretion [GO:0050796]; response to food [GO:0032094]; succinate transmembrane transport [GO:0071422]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10921872, ECO:0000269|PubMed:12946269, ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:24390345, ECO:0000269|PubMed:25957687}; Multi-pass membrane protein {ECO:0000269|PubMed:33333023}. Basolateral cell membrane {ECO:0000250|UniProtKB:P53987}; Multi-pass membrane protein {ECO:0000269|PubMed:33333023}. Apical cell membrane {ECO:0000269|PubMed:15901598}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P53987}. Note=Expression at the cell surface requires the ancillary proteins BSG and EMB. Binds preferentially to BSG. {ECO:0000269|PubMed:10921872}.
P53990	reviewed	IST1_HUMAN	IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28)	IST1 KIAA0174	Homo sapiens (Human)	364	FUNCTION: ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129480, PubMed:19129479). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.		abscission [GO:0009838]; cell division [GO:0051301]; collateral sprouting [GO:0048668]; cytoskeleton-dependent cytokinesis [GO:0061640]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; multivesicular body assembly [GO:0036258]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of proteolysis [GO:0045862]; protein localization [GO:0008104]; protein transport [GO:0015031]; viral capsid secondary envelopment [GO:0046745]; viral release from host cell [GO:0019076]	azurophil granule lumen [GO:0035578]; centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Flemming body [GO:0090543]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nuclear envelope [GO:0005635]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; MIT domain binding [GO:0090541]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]	azurophil granule lumen [GO:0035578]; centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Flemming body [GO:0090543]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; MIT domain binding [GO:0090541]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; abscission [GO:0009838]; cell division [GO:0051301]; collateral sprouting [GO:0048668]; cytoskeleton-dependent cytokinesis [GO:0061640]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; multivesicular body assembly [GO:0036258]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of proteolysis [GO:0045862]; protein localization [GO:0008104]; protein transport [GO:0015031]; viral capsid secondary envelopment [GO:0046745]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20719964}. Midbody {ECO:0000269|PubMed:20719964}. Nucleus envelope {ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. Note=Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964). Colocalized with SPART to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the reforming nuclear envelope on chromatin disks during late anaphase. {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:20719964, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.
P53992	reviewed	SC24C_HUMAN	Protein transport protein Sec24C (SEC24-related protein C)	SEC24C KIAA0079	Homo sapiens (Human)	1094	FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}.		COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; in utero embryonic development [GO:0001701]; intracellular protein transport [GO:0006886]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]	SNARE binding [GO:0000149]; zinc ion binding [GO:0008270]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; SNARE binding [GO:0000149]; zinc ion binding [GO:0008270]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; in utero embryonic development [GO:0001701]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:10075675, ECO:0000269|PubMed:10329445}; Peripheral membrane protein {ECO:0000269|PubMed:10075675}; Cytoplasmic side {ECO:0000269|PubMed:10075675}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10075675, ECO:0000269|PubMed:10329445}; Peripheral membrane protein {ECO:0000269|PubMed:10075675}; Cytoplasmic side {ECO:0000269|PubMed:10075675}. Cytoplasm, cytosol {ECO:0000269|PubMed:10075675}.
P53999	reviewed	TCP4_HUMAN	Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14)	SUB1 PC4 RPO2TC1	Homo sapiens (Human)	127	FUNCTION: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). {ECO:0000269|PubMed:16605275, ECO:0000269|PubMed:16689930, ECO:0000269|PubMed:7628453, ECO:0000269|PubMed:8062391, ECO:0000269|PubMed:8062392, ECO:0000269|PubMed:9360603, ECO:0000269|PubMed:9482861}.		negative regulation of DNA duplex unwinding [GO:1905463]; negative regulation of DNA metabolic process [GO:0051053]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II promoter clearance [GO:0001111]; SMAD protein signal transduction [GO:0060395]	extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713]	extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713]; negative regulation of DNA duplex unwinding [GO:1905463]; negative regulation of DNA metabolic process [GO:0051053]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II promoter clearance [GO:0001111]; SMAD protein signal transduction [GO:0060395]	SUBCELLULAR LOCATION: Nucleus.
P54098	reviewed	DPOG1_HUMAN	DNA polymerase subunit gamma-1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha)	POLG MDP1 POLG1 POLGA	Homo sapiens (Human)	1239	FUNCTION: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.		base-excision repair, gap-filling [GO:0006287]; DNA metabolic process [GO:0006259]; DNA-templated DNA replication [GO:0006261]; mitochondrial DNA replication [GO:0006264]	gamma DNA polymerase complex [GO:0005760]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	3'-5' exonuclease activity [GO:0008408]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; protease binding [GO:0002020]	gamma DNA polymerase complex [GO:0005760]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; 3'-5' exonuclease activity [GO:0008408]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; protease binding [GO:0002020]; base-excision repair, gap-filling [GO:0006287]; DNA metabolic process [GO:0006259]; DNA-templated DNA replication [GO:0006261]; mitochondrial DNA replication [GO:0006264]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18063578}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.
P54105	reviewed	ICLN_HUMAN	Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)	CLNS1A CLCI ICLN	Homo sapiens (Human)	237	FUNCTION: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:21081503, PubMed:18984161, PubMed:10330151, PubMed:11713266). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:10330151). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:10330151). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:10330151, PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:10330151, PubMed:18984161). {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713266, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}.		cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; mRNA cis splicing, via spliceosome [GO:0045292]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; spliceosomal snRNP assembly [GO:0000387]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; plasma membrane [GO:0005886]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; plasma membrane [GO:0005886]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; mRNA cis splicing, via spliceosome [GO:0045292]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Nucleus {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18984161}. Note=A small fraction is also associated with the cytoskeleton (PubMed:18984161).
P54107	reviewed	CRIS1_HUMAN	Cysteine-rich secretory protein 1 (CRISP-1) (AEG-like protein) (ARP) (Acidic epididymal glycoprotein homolog)	CRISP1 AEGL1	Homo sapiens (Human)	249	FUNCTION: May have a role in sperm-egg fusion and maturation.		binding of sperm to zona pellucida [GO:0007339]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; regulation of acrosome reaction [GO:0060046]	extracellular space [GO:0005615]; nucleus [GO:0005634]	calcium channel regulator activity [GO:0005246]	extracellular space [GO:0005615]; nucleus [GO:0005634]; calcium channel regulator activity [GO:0005246]; binding of sperm to zona pellucida [GO:0007339]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; regulation of acrosome reaction [GO:0060046]	SUBCELLULAR LOCATION: Note=Located in the lumen and epithelium of distal ductus efferentes and epididymal ducts, and on the postacrosomal region of the sperm head.
P54108	reviewed	CRIS3_HUMAN	Cysteine-rich secretory protein 3 (CRISP-3) (Specific granule protein of 28 kDa) (SGP28)	CRISP3	Homo sapiens (Human)	245			defense response [GO:0006952]; innate immune response [GO:0045087]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]		extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; defense response [GO:0006952]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted. Note=In neutrophils, localized in specific granules.
P54132	reviewed	BLM_HUMAN	RecQ-like DNA helicase BLM (EC 3.6.4.12) (Bloom syndrome protein) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)	BLM RECQ2 RECQL3	Homo sapiens (Human)	1417	FUNCTION: ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:9388193, PubMed:24816114, PubMed:25901030). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (PubMed:20639533, PubMed:24257077, PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}.		cellular response to camptothecin [GO:0072757]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; G-quadruplex DNA unwinding [GO:0044806]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cell division [GO:0051782]; negative regulation of DNA recombination [GO:0045910]; positive regulation of DNA-templated transcription [GO:0045893]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of DNA-templated DNA replication [GO:0090329]; replication fork processing [GO:0031297]; resolution of recombination intermediates [GO:0071139]; response to X-ray [GO:0010165]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral element [GO:0000800]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; RecQ family helicase-topoisomerase III complex [GO:0031422]; replication fork [GO:0005657]	3'-5' DNA helicase activity [GO:0043138]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; bubble DNA binding [GO:0000405]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA/DNA annealing activity [GO:1990814]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; molecular function activator activity [GO:0140677]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; single-stranded DNA binding [GO:0003697]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral element [GO:0000800]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; RecQ family helicase-topoisomerase III complex [GO:0031422]; replication fork [GO:0005657]; 3'-5' DNA helicase activity [GO:0043138]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; bubble DNA binding [GO:0000405]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA/DNA annealing activity [GO:1990814]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; molecular function activator activity [GO:0140677]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; single-stranded DNA binding [GO:0003697]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]; zinc ion binding [GO:0008270]; cellular response to camptothecin [GO:0072757]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; G-quadruplex DNA unwinding [GO:0044806]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cell division [GO:0051782]; negative regulation of DNA recombination [GO:0045910]; positive regulation of DNA-templated transcription [GO:0045893]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of DNA-templated DNA replication [GO:0090329]; replication fork processing [GO:0031297]; resolution of recombination intermediates [GO:0071139]; response to X-ray [GO:0010165]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23509288}. Note=Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner.
P54136	reviewed	SYRC_HUMAN	Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)	RARS1 RARS	Homo sapiens (Human)	660	FUNCTION: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684). {ECO:0000269|PubMed:17443684, ECO:0000269|PubMed:25288775}.		arginyl-tRNA aminoacylation [GO:0006420]; tRNA aminoacylation for protein translation [GO:0006418]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	arginine binding [GO:0034618]; arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; tRNA binding [GO:0000049]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; arginine binding [GO:0034618]; arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; tRNA binding [GO:0000049]; arginyl-tRNA aminoacylation [GO:0006420]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:16055448, ECO:0000269|PubMed:16430231}. Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}.
P54198	reviewed	HIRA_HUMAN	Protein HIRA (TUP1-like enhancer of split protein 1)	HIRA DGCR1 HIR TUPLE1	Homo sapiens (Human)	1017	FUNCTION: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}.		anatomical structure morphogenesis [GO:0009653]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; gastrulation [GO:0007369]; muscle cell differentiation [GO:0042692]; nucleosome assembly [GO:0006334]; osteoblast differentiation [GO:0001649]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; extracellular exosome [GO:0070062]; HIR complex [GO:0000417]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]	histone binding [GO:0042393]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; extracellular exosome [GO:0070062]; HIR complex [GO:0000417]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; histone binding [GO:0042393]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; anatomical structure morphogenesis [GO:0009653]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; gastrulation [GO:0007369]; muscle cell differentiation [GO:0042692]; nucleosome assembly [GO:0006334]; osteoblast differentiation [GO:0001649]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
P54219	reviewed	VMAT1_HUMAN	Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1)	SLC18A1 VAT1 VMAT1	Homo sapiens (Human)	525	FUNCTION: [Isoform 1]: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin (PubMed:23337945, PubMed:8643547, PubMed:16326835). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli (PubMed:23337945). {ECO:0000269|PubMed:16326835, ECO:0000269|PubMed:23337945, ECO:0000269|PubMed:8643547}.; FUNCTION: [Isoform 2]: Unable to uptake serotonin. {ECO:0000269|PubMed:16326835}.		aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; dopamine uptake [GO:0090494]; monoamine transport [GO:0015844]; norepinephrine uptake [GO:0051620]; serotonin uptake [GO:0051610]	clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; endoplasmic reticulum membrane [GO:0005789]; presynapse [GO:0098793]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	monoamine transmembrane transporter activity [GO:0008504]; monoamine:proton antiporter activity [GO:0015311]; serotonin:sodium:chloride symporter activity [GO:0005335]; xenobiotic transmembrane transporter activity [GO:0042910]	clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; endoplasmic reticulum membrane [GO:0005789]; presynapse [GO:0098793]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; monoamine transmembrane transporter activity [GO:0008504]; monoamine:proton antiporter activity [GO:0015311]; serotonin:sodium:chloride symporter activity [GO:0005335]; xenobiotic transmembrane transporter activity [GO:0042910]; aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; dopamine uptake [GO:0090494]; monoamine transport [GO:0015844]; norepinephrine uptake [GO:0051620]; serotonin uptake [GO:0051610]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:8643547}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8R090}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:16326835}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16326835}; Multi-pass membrane protein {ECO:0000255}.
P54252	reviewed	ATX3_HUMAN	Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein)	ATXN3 ATX3 MJD MJD1 SCA3	Homo sapiens (Human)	361	FUNCTION: Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:33157014}.		actin cytoskeleton organization [GO:0030036]; cellular response to amino acid starvation [GO:0034198]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; chemical synaptic transmission [GO:0007268]; exploration behavior [GO:0035640]; intermediate filament cytoskeleton organization [GO:0045104]; microtubule cytoskeleton organization [GO:0000226]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of TORC1 signaling [GO:1904262]; nervous system development [GO:0007399]; nucleotide-excision repair [GO:0006289]; positive regulation of ERAD pathway [GO:1904294]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein localization to cytosolic proteasome complex involved in ERAD pathway [GO:1904379]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of cell-substrate adhesion [GO:0010810]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; nuclear inclusion body [GO:0042405]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]	ATPase binding [GO:0051117]; cysteine-type deubiquitinase activity [GO:0004843]; identical protein binding [GO:0042802]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; nuclear inclusion body [GO:0042405]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; ATPase binding [GO:0051117]; cysteine-type deubiquitinase activity [GO:0004843]; identical protein binding [GO:0042802]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; ubiquitin protein ligase binding [GO:0031625]; actin cytoskeleton organization [GO:0030036]; cellular response to amino acid starvation [GO:0034198]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; chemical synaptic transmission [GO:0007268]; exploration behavior [GO:0035640]; intermediate filament cytoskeleton organization [GO:0045104]; microtubule cytoskeleton organization [GO:0000226]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of TORC1 signaling [GO:1904262]; nervous system development [GO:0007399]; nucleotide-excision repair [GO:0006289]; positive regulation of ERAD pathway [GO:1904294]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein localization to cytosolic proteasome complex involved in ERAD pathway [GO:1904379]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of cell-substrate adhesion [GO:0010810]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:9580663}. Nucleus {ECO:0000269|PubMed:30455355}. Lysosome membrane {ECO:0000269|PubMed:33157014}; Peripheral membrane protein {ECO:0000269|PubMed:33157014}. Note=Predominantly nuclear, but not exclusively, inner nuclear matrix (PubMed:9580663). Recruited to lysosomal membrane in response to amino acid deprivation by the RagA/RRAGA-RagB/RRAGB complex (PubMed:33157014). {ECO:0000269|PubMed:33157014, ECO:0000269|PubMed:9580663}.
P54253	reviewed	ATX1_HUMAN	Ataxin-1 (Spinocerebellar ataxia type 1 protein)	ATXN1 ATX1 SCA1	Homo sapiens (Human)	815	FUNCTION: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P54254, ECO:0000269|PubMed:21475249}.	MISCELLANEOUS: Self-association seems to be necessary for formation of nuclear aggregates which are associated with pathogenesis.	brain development [GO:0007420]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; nuclear export [GO:0051168]; RNA processing [GO:0006396]; social behavior [GO:0035176]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear inclusion body [GO:0042405]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; protein self-association [GO:0043621]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear inclusion body [GO:0042405]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; protein self-association [GO:0043621]; brain development [GO:0007420]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; nuclear export [GO:0051168]; RNA processing [GO:0006396]; social behavior [GO:0035176]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7647801}. Nucleus {ECO:0000269|PubMed:12093161, ECO:0000269|PubMed:7647801}. Note=Colocalizes with USP7 in the nucleus. {ECO:0000269|PubMed:12093161}.
P54257	reviewed	HAP1_HUMAN	Huntingtin-associated protein 1 (HAP-1) (Neuroan 1)	HAP1 HAP2 HLP1	Homo sapiens (Human)	671	FUNCTION: Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17). {ECO:0000269|PubMed:18922795}.	MISCELLANEOUS: Was not found in huntingtin-containing aggregates in huntigton disease (HD) tissue.	anterograde axonal transport [GO:0008089]; anterograde axonal transport of mitochondrion [GO:0098957]; autophagy [GO:0006914]; brain development [GO:0007420]; cell projection organization [GO:0030030]; cerebellum development [GO:0021549]; chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; hypothalamus cell differentiation [GO:0021979]; mitochondrion distribution [GO:0048311]; negative regulation of amyloid-beta formation [GO:1902430]; neurogenesis [GO:0022008]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neurotrophin production [GO:0032901]; positive regulation of non-motile cilium assembly [GO:1902857]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; protein localization [GO:0008104]; protein targeting [GO:0006605]; regulation of exocytosis [GO:0017157]; regulation of organelle transport along microtubule [GO:1902513]; retrograde axonal transport [GO:0008090]; vesicle transport along microtubule [GO:0047496]	actin cytoskeleton [GO:0015629]; autophagosome [GO:0005776]; axon cytoplasm [GO:1904115]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; inclusion body [GO:0016234]; lysosome [GO:0005764]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; synaptic vesicle [GO:0008021]	brain-derived neurotrophic factor binding [GO:0048403]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]	actin cytoskeleton [GO:0015629]; autophagosome [GO:0005776]; axon cytoplasm [GO:1904115]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; inclusion body [GO:0016234]; lysosome [GO:0005764]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; synaptic vesicle [GO:0008021]; brain-derived neurotrophic factor binding [GO:0048403]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; anterograde axonal transport [GO:0008089]; anterograde axonal transport of mitochondrion [GO:0098957]; autophagy [GO:0006914]; brain development [GO:0007420]; cell projection organization [GO:0030030]; cerebellum development [GO:0021549]; chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; hypothalamus cell differentiation [GO:0021979]; mitochondrion distribution [GO:0048311]; negative regulation of amyloid-beta formation [GO:1902430]; neurogenesis [GO:0022008]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neurotrophin production [GO:0032901]; positive regulation of non-motile cilium assembly [GO:1902857]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; protein localization [GO:0008104]; protein targeting [GO:0006605]; regulation of exocytosis [GO:0017157]; regulation of organelle transport along microtubule [GO:1902513]; retrograde axonal transport [GO:0008090]; vesicle transport along microtubule [GO:0047496]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9742138}. Cell projection, axon {ECO:0000269|PubMed:9742138}. Presynapse {ECO:0000250|UniProtKB:P54256}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P54256}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P54256}. Cell projection, dendrite {ECO:0000250|UniProtKB:P54256}. Lysosome {ECO:0000250|UniProtKB:P54256}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P54256}. Mitochondrion {ECO:0000305|PubMed:9742138}. Nucleus {ECO:0000250|UniProtKB:P54256}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:O35668}. Early endosome {ECO:0000250|UniProtKB:P54256}. Cell projection, growth cone {ECO:0000250|UniProtKB:P54256}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P54256}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:P54256}. Note=Localizes to large nonmembrane-bound cytoplasmic bodies found in various types of neurons, called stigmoid bodies (STBs). Localization to neuronal processes and neurite tips is decreased by YWHAZ. In the nucleus localizes to nuclear rods. {ECO:0000250|UniProtKB:P54256}.
P54259	reviewed	ATN1_HUMAN	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)	ATN1 D12S755E DRPLA	Homo sapiens (Human)	1190	FUNCTION: Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}.		cell killing [GO:0001906]; cell migration [GO:0016477]; central nervous system development [GO:0007417]; determination of adult lifespan [GO:0008340]; maintenance of cell polarity [GO:0030011]; male gonad development [GO:0008584]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; post-embryonic development [GO:0009791]; response to food [GO:0032094]; spermatogenesis [GO:0007283]	anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	protein domain specific binding [GO:0019904]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein domain specific binding [GO:0019904]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; cell killing [GO:0001906]; cell migration [GO:0016477]; central nervous system development [GO:0007417]; determination of adult lifespan [GO:0008340]; maintenance of cell polarity [GO:0030011]; male gonad development [GO:0008584]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; post-embryonic development [GO:0009791]; response to food [GO:0032094]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, perinuclear region. Cell junction {ECO:0000250|UniProtKB:P54258}. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells (By similarity). Colocalizes with MTG8 in discrete nuclear dots. Proteolytic fragment F1 appears to remain in nucleus. Fragment F2 is exported into the cytoplasm. Fragment F2 from mutant sequences with longer poly-Gln (polyQ) tracts are additionally located to the cytoplasmic membrane and to certain organelles. {ECO:0000250}.
P54274	reviewed	TERF1_HUMAN	Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1)	TERF1 PIN2 TRBF1 TRF TRF1	Homo sapiens (Human)	439	FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. {ECO:0000269|PubMed:16166375}.		cell division [GO:0051301]; meiotic telomere clustering [GO:0045141]; negative regulation of DNA replication [GO:0008156]; negative regulation of establishment of protein localization to telomere [GO:1904850]; negative regulation of establishment of protein-containing complex localization to telomere [GO:1904914]; negative regulation of establishment of RNA localization to telomere [GO:1904911]; negative regulation of exonuclease activity [GO:1905778]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via semi-conservative replication [GO:0032214]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric D-loop disassembly [GO:1905839]; positive regulation of shelterin complex assembly [GO:1904792]; positive regulation of telomere maintenance [GO:0032206]; t-circle formation [GO:0090656]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomeric D-loop disassembly [GO:0061820]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; shelterin complex [GO:0070187]; spindle [GO:0005819]	ankyrin repeat binding [GO:0071532]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; double-stranded telomeric DNA binding [GO:0003691]; G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; telomeric DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; shelterin complex [GO:0070187]; spindle [GO:0005819]; ankyrin repeat binding [GO:0071532]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; double-stranded telomeric DNA binding [GO:0003691]; G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; telomeric DNA binding [GO:0042162]; cell division [GO:0051301]; meiotic telomere clustering [GO:0045141]; negative regulation of DNA replication [GO:0008156]; negative regulation of establishment of protein localization to telomere [GO:1904850]; negative regulation of establishment of protein-containing complex localization to telomere [GO:1904914]; negative regulation of establishment of RNA localization to telomere [GO:1904911]; negative regulation of exonuclease activity [GO:1905778]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via semi-conservative replication [GO:0032214]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric D-loop disassembly [GO:1905839]; positive regulation of shelterin complex assembly [GO:1904792]; positive regulation of telomere maintenance [GO:0032206]; t-circle formation [GO:0090656]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomeric D-loop disassembly [GO:0061820]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24692559}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11943150}. Chromosome, telomere {ECO:0000269|PubMed:24692559}. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle (PubMed:11943150). Colocalizes with TRIOBP isoform 1 at the telomeres in interphase (PubMed:24692559). {ECO:0000269|PubMed:11943150, ECO:0000269|PubMed:24692559}.
P54277	reviewed	PMS1_HUMAN	PMS1 protein homolog 1 (DNA mismatch repair protein PMS1)	PMS1 PMSL1	Homo sapiens (Human)	932	FUNCTION: Probably involved in the repair of mismatches in DNA. {ECO:0000269|PubMed:10748105}.		mismatch repair [GO:0006298]; response to xenobiotic stimulus [GO:0009410]	MutLalpha complex [GO:0032389]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; mismatched DNA binding [GO:0030983]	MutLalpha complex [GO:0032389]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; mismatched DNA binding [GO:0030983]; mismatch repair [GO:0006298]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
P54278	reviewed	PMS2_HUMAN	Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2)	PMS2 PMSL2	Homo sapiens (Human)	862	FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}.		mismatch repair [GO:0006298]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; response to xenobiotic stimulus [GO:0009410]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]	cytosol [GO:0005829]; MutLalpha complex [GO:0032389]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; single base insertion or deletion binding [GO:0032138]	cytosol [GO:0005829]; MutLalpha complex [GO:0032389]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; single base insertion or deletion binding [GO:0032138]; mismatch repair [GO:0006298]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; response to xenobiotic stimulus [GO:0009410]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781}.
P54284	reviewed	CACB3_HUMAN	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3)	CACNB3 CACNLB3	Homo sapiens (Human)	484	FUNCTION: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). {ECO:0000250|UniProtKB:P54287, ECO:0000250|UniProtKB:Q9MZL3, ECO:0000269|PubMed:8119293}.		calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; chemical synaptic transmission [GO:0007268]; neuromuscular junction development [GO:0007528]; positive regulation of high voltage-gated calcium channel activity [GO:1901843]; protein localization to plasma membrane [GO:0072659]; regulation of membrane repolarization during action potential [GO:0098903]; T cell receptor signaling pathway [GO:0050852]	cytosol [GO:0005829]; L-type voltage-gated calcium channel complex [GO:1990454]; membrane [GO:0016020]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]	calcium channel regulator activity [GO:0005246]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245]	cytosol [GO:0005829]; L-type voltage-gated calcium channel complex [GO:1990454]; membrane [GO:0016020]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]; calcium channel regulator activity [GO:0005246]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245]; calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; chemical synaptic transmission [GO:0007268]; neuromuscular junction development [GO:0007528]; positive regulation of high voltage-gated calcium channel activity [GO:1901843]; protein localization to plasma membrane [GO:0072659]; regulation of membrane repolarization during action potential [GO:0098903]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34234349}.
P54289	reviewed	CA2D1_HUMAN	Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1]	CACNA2D1 CACNL2A CCHL2A MHS3	Homo sapiens (Human)	1103	FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (PubMed:35293990). Plays an important role in excitation-contraction coupling (By similarity). {ECO:0000250, ECO:0000269|PubMed:35293990}.	MISCELLANEOUS: Binds gabapentin, an antiepileptic drug.	calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to amyloid-beta [GO:1904646]; membrane depolarization during bundle of His cell action potential [GO:0086048]; positive regulation of high voltage-gated calcium channel activity [GO:1901843]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of calcium ion transport [GO:0051924]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization during action potential [GO:0098903]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]	extracellular exosome [GO:0070062]; L-type voltage-gated calcium channel complex [GO:1990454]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; voltage-gated calcium channel complex [GO:0005891]	metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]	extracellular exosome [GO:0070062]; L-type voltage-gated calcium channel complex [GO:1990454]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; voltage-gated calcium channel complex [GO:0005891]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to amyloid-beta [GO:1904646]; membrane depolarization during bundle of His cell action potential [GO:0086048]; positive regulation of high voltage-gated calcium channel activity [GO:1901843]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of calcium ion transport [GO:0051924]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization during action potential [GO:0098903]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:35293990}.
P54296	reviewed	MYOM2_HUMAN	Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2)	MYOM2	Homo sapiens (Human)	1465	FUNCTION: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.		extraocular skeletal muscle development [GO:0002074]; muscle contraction [GO:0006936]; sarcomere organization [GO:0045214]	M band [GO:0031430]; mitochondrion [GO:0005739]; myosin filament [GO:0032982]	kinase binding [GO:0019900]; structural constituent of muscle [GO:0008307]	M band [GO:0031430]; mitochondrion [GO:0005739]; myosin filament [GO:0032982]; kinase binding [GO:0019900]; structural constituent of muscle [GO:0008307]; extraocular skeletal muscle development [GO:0002074]; muscle contraction [GO:0006936]; sarcomere organization [GO:0045214]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}.
P54315	reviewed	LIPR1_HUMAN	Inactive pancreatic lipase-related protein 1 (PL-RP1)	PNLIPRP1 PLRP1	Homo sapiens (Human)	467	FUNCTION: May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity). {ECO:0000250, ECO:0000269|PubMed:19824014}.		lipid metabolic process [GO:0006629]	extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; triglyceride lipase activity [GO:0004806]	extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; triglyceride lipase activity [GO:0004806]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1379598, ECO:0000269|PubMed:19824014}.
P54317	reviewed	LIPR2_HUMAN	Pancreatic lipase-related protein 2 (PL-RP2) (Cytotoxic T lymphocyte lipase) (Galactolipase) (EC 3.1.1.26) (Triacylglycerol lipase) (EC 3.1.1.3)	PNLIPRP2 PLRP2	Homo sapiens (Human)	469	FUNCTION: Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:15287741, PubMed:17401110, PubMed:19451396, PubMed:21865348, PubMed:20083229, PubMed:26494624, PubMed:18702514). In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (PubMed:23732775, PubMed:19824014, PubMed:21652702). Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:15287741, PubMed:17401110, PubMed:21865348, PubMed:21652702, PubMed:18702514). Can completely deacylate triacylglycerols (PubMed:21865348). When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (PubMed:15287741, PubMed:17401110, PubMed:20083229, PubMed:26494624, PubMed:18702514). Hydrolyzes medium- and long-chain fatty acyls in galactolipids (PubMed:20083229, PubMed:18702514). May act together with LIPF to hydrolyze partially digested triglycerides (PubMed:23732775). Hydrolyzes long-chain monoglycerides with high efficiency (PubMed:17401110, PubMed:21652702, PubMed:23732775). In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity (PubMed:17401110, PubMed:18702514). In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P17892, ECO:0000250|UniProtKB:P54318, ECO:0000269|PubMed:15287741, ECO:0000269|PubMed:17401110, ECO:0000269|PubMed:18702514, ECO:0000269|PubMed:19451396, ECO:0000269|PubMed:19824014, ECO:0000269|PubMed:20083229, ECO:0000269|PubMed:21652702, ECO:0000269|PubMed:21865348, ECO:0000269|PubMed:23732775, ECO:0000269|PubMed:26494624}.		galactolipid catabolic process [GO:0019376]; lipid digestion [GO:0044241]; phosphatidylcholine catabolic process [GO:0034638]; phospholipid catabolic process [GO:0009395]; triglyceride catabolic process [GO:0019433]; triglyceride metabolic process [GO:0006641]	cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuron projection [GO:0043005]	1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity [GO:0102549]; acylglycerol lipase activity [GO:0047372]; calcium ion binding [GO:0005509]; galactolipase activity [GO:0047714]; phospholipase activity [GO:0004620]; triglyceride lipase activity [GO:0004806]	cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuron projection [GO:0043005]; 1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity [GO:0102549]; acylglycerol lipase activity [GO:0047372]; calcium ion binding [GO:0005509]; galactolipase activity [GO:0047714]; phospholipase activity [GO:0004620]; triglyceride lipase activity [GO:0004806]; galactolipid catabolic process [GO:0019376]; lipid digestion [GO:0044241]; phosphatidylcholine catabolic process [GO:0034638]; phospholipid catabolic process [GO:0009395]; triglyceride catabolic process [GO:0019433]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18702514, ECO:0000269|PubMed:19824014}. Zymogen granule membrane {ECO:0000250|UniProtKB:P54318}; Peripheral membrane protein {ECO:0000250|UniProtKB:P54318}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P54318}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000250|UniProtKB:P54318}.
P54368	reviewed	OAZ1_HUMAN	Ornithine decarboxylase antizyme 1 (AZ1) (ODC-Az)	OAZ1 OAZ	Homo sapiens (Human)	228	FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147). {ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:26305948, ECO:0000269|PubMed:26443277}.		negative regulation of polyamine transmembrane transport [GO:1902268]; polyamine biosynthetic process [GO:0006596]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein catabolic process [GO:0045732]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ornithine decarboxylase inhibitor activity [GO:0008073]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ornithine decarboxylase inhibitor activity [GO:0008073]; negative regulation of polyamine transmembrane transport [GO:1902268]; polyamine biosynthetic process [GO:0006596]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein catabolic process [GO:0045732]	
P54577	reviewed	SYYC_HUMAN	Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed]	YARS1 YARS	Homo sapiens (Human)	528	FUNCTION: Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) (PubMed:25533949). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity (PubMed:25533949). Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:25533949). {ECO:0000269|PubMed:25533949, ECO:0000305|PubMed:16429158, ECO:0000305|PubMed:9162081}.		apoptotic process [GO:0006915]; response to starvation [GO:0042594]; tyrosyl-tRNA aminoacylation [GO:0006437]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nuclear body [GO:0016604]; nucleus [GO:0005634]	ATP binding [GO:0005524]; interleukin-8 receptor binding [GO:0005153]; resveratrol binding [GO:1905594]; RNA binding [GO:0003723]; small molecule binding [GO:0036094]; tRNA binding [GO:0000049]; tyrosine-tRNA ligase activity [GO:0004831]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nuclear body [GO:0016604]; nucleus [GO:0005634]; ATP binding [GO:0005524]; interleukin-8 receptor binding [GO:0005153]; resveratrol binding [GO:1905594]; RNA binding [GO:0003723]; small molecule binding [GO:0036094]; tRNA binding [GO:0000049]; tyrosine-tRNA ligase activity [GO:0004831]; apoptotic process [GO:0006915]; response to starvation [GO:0042594]; tyrosyl-tRNA aminoacylation [GO:0006437]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16429158, ECO:0000269|PubMed:30304524, ECO:0000305|PubMed:9162081}. Nucleus {ECO:0000269|PubMed:22291016, ECO:0000269|PubMed:25533949}. Note=Cytoplasmic in normal conditions (PubMed:25533949). Resveratrol-binding in response to serum starvation promotes relocalization to the nucleus (PubMed:25533949). {ECO:0000269|PubMed:25533949}.
P54578	reviewed	UBP14_HUMAN	Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)	USP14 TGT	Homo sapiens (Human)	494	FUNCTION: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413}.		chemical synaptic transmission [GO:0007268]; innate immune response [GO:0045087]; negative regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of chemotaxis [GO:0050920]; regulation of proteasomal protein catabolic process [GO:0061136]	cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; synapse [GO:0045202]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase inhibitor activity [GO:0004866]; K63-linked deubiquitinase activity [GO:0061578]; proteasome binding [GO:0070628]	cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; synapse [GO:0045202]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase inhibitor activity [GO:0004866]; K63-linked deubiquitinase activity [GO:0061578]; proteasome binding [GO:0070628]; chemical synaptic transmission [GO:0007268]; innate immune response [GO:0045087]; negative regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of chemotaxis [GO:0050920]; regulation of proteasomal protein catabolic process [GO:0061136]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19106094}. Cell membrane {ECO:0000269|PubMed:19106094}; Peripheral membrane protein {ECO:0000269|PubMed:19106094}.
P54619	reviewed	AAKG1_HUMAN	5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg)	PRKAG1	Homo sapiens (Human)	331	FUNCTION: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. {ECO:0000269|PubMed:21680840}.	MISCELLANEOUS: [Isoform 3]: May be due to competing acceptor splice site. {ECO:0000305}.	cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; import into nucleus [GO:0051170]; positive regulation of gene expression [GO:0010628]; positive regulation of protein kinase activity [GO:0045860]; protein phosphorylation [GO:0006468]; regulation of glycolytic process [GO:0006110]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]	ADP binding [GO:0043531]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; ADP binding [GO:0043531]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; import into nucleus [GO:0051170]; positive regulation of gene expression [GO:0010628]; positive regulation of protein kinase activity [GO:0045860]; protein phosphorylation [GO:0006468]; regulation of glycolytic process [GO:0006110]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	
P54646	reviewed	AAPK2_HUMAN	5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31)	PRKAA2 AMPK AMPK2	Homo sapiens (Human)	552	FUNCTION: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11554766, PubMed:11518699, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}.		autophagy [GO:0006914]; cellular response to calcium ion [GO:0071277]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to nutrient levels [GO:0031669]; cellular response to oxidative stress [GO:0034599]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol biosynthetic process [GO:0006695]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; intracellular signal transduction [GO:0035556]; lipid biosynthetic process [GO:0008610]; lipid droplet disassembly [GO:1905691]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of tubulin deacetylation [GO:1904428]; positive regulation of autophagy [GO:0010508]; positive regulation of glycolytic process [GO:0045821]; positive regulation of macroautophagy [GO:0016239]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization [GO:1903829]; protein localization to lipid droplet [GO:1990044]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of macroautophagy [GO:0016241]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of stress granule assembly [GO:0062028]; response to muscle activity [GO:0014850]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	axon [GO:0030424]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]	[acetyl-CoA carboxylase] kinase activity [GO:0050405]; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity [GO:0047322]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; histone H2BS36 kinase activity [GO:0140823]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]	axon [GO:0030424]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; [acetyl-CoA carboxylase] kinase activity [GO:0050405]; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity [GO:0047322]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; histone H2BS36 kinase activity [GO:0140823]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; autophagy [GO:0006914]; cellular response to calcium ion [GO:0071277]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to nutrient levels [GO:0031669]; cellular response to oxidative stress [GO:0034599]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol biosynthetic process [GO:0006695]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; intracellular signal transduction [GO:0035556]; lipid biosynthetic process [GO:0008610]; lipid droplet disassembly [GO:1905691]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of tubulin deacetylation [GO:1904428]; positive regulation of autophagy [GO:0010508]; positive regulation of glycolytic process [GO:0045821]; positive regulation of macroautophagy [GO:0016239]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization [GO:1903829]; protein localization to lipid droplet [GO:1990044]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of macroautophagy [GO:0016241]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of stress granule assembly [GO:0062028]; response to muscle activity [GO:0014850]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BRK8}. Nucleus {ECO:0000269|PubMed:15866171}. Note=In response to stress, recruited by p53/TP53 to specific promoters. {ECO:0000269|PubMed:15866171}.
P54652	reviewed	HSP72_HUMAN	Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2)	HSPA2	Homo sapiens (Human)	639	FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}.		chaperone cofactor-dependent protein refolding [GO:0051085]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; negative regulation of inclusion body assembly [GO:0090084]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of protein phosphorylation [GO:0001934]; protein refolding [GO:0042026]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex disassembly [GO:0070194]	blood microparticle [GO:0072562]; CatSper complex [GO:0036128]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; meiotic spindle [GO:0072687]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synaptonemal complex [GO:0000795]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; glycolipid binding [GO:0051861]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; tau protein binding [GO:0048156]; unfolded protein binding [GO:0051082]	blood microparticle [GO:0072562]; CatSper complex [GO:0036128]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; meiotic spindle [GO:0072687]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synaptonemal complex [GO:0000795]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; glycolipid binding [GO:0051861]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; tau protein binding [GO:0048156]; unfolded protein binding [GO:0051082]; chaperone cofactor-dependent protein refolding [GO:0051085]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; negative regulation of inclusion body assembly [GO:0090084]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of protein phosphorylation [GO:0001934]; protein refolding [GO:0042026]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex disassembly [GO:0070194]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P17156}. Note=Colocalizes with SHCBP1L at spindle during the meiosis process. {ECO:0000250|UniProtKB:P17156}.
P54687	reviewed	BCAT1_HUMAN	Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) (Protein ECA39)	BCAT1 BCT1 ECA39	Homo sapiens (Human)	386	FUNCTION: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.		branched-chain amino acid biosynthetic process [GO:0009082]; G1/S transition of mitotic cell cycle [GO:0000082]; leucine biosynthetic process [GO:0009098]; lipid metabolic process [GO:0006629]; valine biosynthetic process [GO:0009099]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	branched-chain-amino-acid transaminase activity [GO:0004084]; L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-leucine:2-oxoglutarate aminotransferase activity [GO:0050048]; L-valine transaminase activity [GO:0052655]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; branched-chain-amino-acid transaminase activity [GO:0004084]; L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-leucine:2-oxoglutarate aminotransferase activity [GO:0050048]; L-valine transaminase activity [GO:0052655]; branched-chain amino acid biosynthetic process [GO:0009082]; G1/S transition of mitotic cell cycle [GO:0000082]; leucine biosynthetic process [GO:0009098]; lipid metabolic process [GO:0006629]; valine biosynthetic process [GO:0009099]	SUBCELLULAR LOCATION: Cytoplasm.
P54707	reviewed	AT12A_HUMAN	Potassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump)	ATP12A ATP1AL1	Homo sapiens (Human)	1039	FUNCTION: The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (PubMed:9774385, PubMed:7485470, PubMed:8853415, PubMed:11341842). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (PubMed:29391451). {ECO:0000250|UniProtKB:Q9Z1W8, ECO:0000269|PubMed:11341842, ECO:0000269|PubMed:29391451, ECO:0000269|PubMed:7485470, ECO:0000269|PubMed:8853415, ECO:0000269|PubMed:9774385}.		intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of pH [GO:0006885]; sodium ion export across plasma membrane [GO:0036376]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; potassium:proton exchanging ATPase complex [GO:0005889]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type potassium:proton transporter activity [GO:0008900]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; potassium:proton exchanging ATPase complex [GO:0005889]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type potassium:proton transporter activity [GO:0008900]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of pH [GO:0006885]; sodium ion export across plasma membrane [GO:0036376]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:16914892}; Multi-pass membrane protein {ECO:0000255}.
P54709	reviewed	AT1B3_HUMAN	Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298)	ATP1B3	Homo sapiens (Human)	279	FUNCTION: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.		intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; membrane repolarization [GO:0086009]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm flagellum [GO:0036126]	ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; protein-macromolecule adaptor activity [GO:0030674]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm flagellum [GO:0036126]; ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; protein-macromolecule adaptor activity [GO:0030674]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; membrane repolarization [GO:0086009]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q63377}; Single-pass type II membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q63377}; Single-pass type II membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
P54710	reviewed	ATNG_HUMAN	Sodium/potassium-transporting ATPase subunit gamma (Na(+)/K(+) ATPase subunit gamma) (FXYD domain-containing ion transport regulator 2) (Sodium pump gamma chain)	FXYD2 ATP1C ATP1G1	Homo sapiens (Human)	66	FUNCTION: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.		establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; positive regulation of P-type sodium:potassium-exchanging transporter activity [GO:1903408]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; sodium ion export across plasma membrane [GO:0036376]; transmembrane transport [GO:0055085]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]	ATPase activator activity [GO:0001671]; protein-macromolecule adaptor activity [GO:0030674]; sodium channel regulator activity [GO:0017080]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; ATPase activator activity [GO:0001671]; protein-macromolecule adaptor activity [GO:0030674]; sodium channel regulator activity [GO:0017080]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; positive regulation of P-type sodium:potassium-exchanging transporter activity [GO:1903408]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; sodium ion export across plasma membrane [GO:0036376]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
P54725	reviewed	RD23A_HUMAN	UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)	RAD23A	Homo sapiens (Human)	363	FUNCTION: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}.		nucleotide-excision repair [GO:0006289]; positive regulation of cell cycle [GO:0045787]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991]	damaged DNA binding [GO:0003684]; kinase binding [GO:0019900]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130]; ubiquitin-specific protease binding [GO:1990381]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991]; damaged DNA binding [GO:0003684]; kinase binding [GO:0019900]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130]; ubiquitin-specific protease binding [GO:1990381]; nucleotide-excision repair [GO:0006289]; positive regulation of cell cycle [GO:0045787]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]	SUBCELLULAR LOCATION: Nucleus.
P54727	reviewed	RD23B_HUMAN	UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)	RAD23B	Homo sapiens (Human)	409	FUNCTION: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.	MISCELLANEOUS: [Isoform 2]: Highly expressed in the testis and in ejaculated spermatozoa. {ECO:0000305}.	cellular response to interleukin-7 [GO:0098761]; nucleotide-excision repair [GO:0006289]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; XPC complex [GO:0071942]	damaged DNA binding [GO:0003684]; DNA damage sensor activity [GO:0140612]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; XPC complex [GO:0071942]; damaged DNA binding [GO:0003684]; DNA damage sensor activity [GO:0140612]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130]; cellular response to interleukin-7 [GO:0098761]; nucleotide-excision repair [GO:0006289]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=The intracellular distribution is cell cycle dependent. Localized to the nucleus and the cytoplasm during G1 phase. Nuclear levels decrease during S-phase; upon entering mitosis, relocalizes in the cytoplasm without association with chromatin.
P54750	reviewed	PDE1A_HUMAN	Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1)	PDE1A	Homo sapiens (Human)	535	FUNCTION: Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. {ECO:0000269|PubMed:8557689}.		cGMP catabolic process [GO:0046069]; regulation of smooth muscle cell apoptotic process [GO:0034391]; regulation of smooth muscle cell proliferation [GO:0048660]; signal transduction [GO:0007165]	cytosol [GO:0005829]; neuronal cell body [GO:0043025]	calmodulin binding [GO:0005516]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; neuronal cell body [GO:0043025]; calmodulin binding [GO:0005516]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]; cGMP catabolic process [GO:0046069]; regulation of smooth muscle cell apoptotic process [GO:0034391]; regulation of smooth muscle cell proliferation [GO:0048660]; signal transduction [GO:0007165]	
P54753	reviewed	EPHB3_HUMAN	Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6)	EPHB3 ETK2 HEK2 TYRO6	Homo sapiens (Human)	998	FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. {ECO:0000269|PubMed:15536074}.		angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; cell migration [GO:0016477]; central nervous system projection neuron axonogenesis [GO:0021952]; corpus callosum development [GO:0022038]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; digestive tract morphogenesis [GO:0048546]; ephrin receptor signaling pathway [GO:0048013]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of axonogenesis [GO:0050770]; regulation of cell-cell adhesion [GO:0022407]; regulation of GTPase activity [GO:0043087]; retinal ganglion cell axon guidance [GO:0031290]; roof of mouth development [GO:0060021]; substrate adhesion-dependent cell spreading [GO:0034446]; thymus development [GO:0048538]; urogenital system development [GO:0001655]	cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; ephrin receptor activity [GO:0005003]; transmembrane-ephrin receptor activity [GO:0005005]	cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; ephrin receptor activity [GO:0005003]; transmembrane-ephrin receptor activity [GO:0005005]; angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; cell migration [GO:0016477]; central nervous system projection neuron axonogenesis [GO:0021952]; corpus callosum development [GO:0022038]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; digestive tract morphogenesis [GO:0048546]; ephrin receptor signaling pathway [GO:0048013]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of axonogenesis [GO:0050770]; regulation of cell-cell adhesion [GO:0022407]; regulation of GTPase activity [GO:0043087]; retinal ganglion cell axon guidance [GO:0031290]; roof of mouth development [GO:0060021]; substrate adhesion-dependent cell spreading [GO:0034446]; thymus development [GO:0048538]; urogenital system development [GO:0001655]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15536074}; Single-pass type I membrane protein {ECO:0000269|PubMed:15536074}. Cell projection, dendrite {ECO:0000250}.
P54756	reviewed	EPHA5_HUMAN	Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)	EPHA5 BSK EHK1 HEK7 TYRO4	Homo sapiens (Human)	1037	FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; cAMP-mediated signaling [GO:0019933]; ephrin receptor signaling pathway [GO:0048013]; hippocampus development [GO:0021766]; neuron development [GO:0048666]; phosphorylation [GO:0016310]; positive regulation of CREB transcription factor activity [GO:0032793]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of GTPase activity [GO:0043087]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]	axon [GO:0030424]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]	ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003]; GPI-linked ephrin receptor activity [GO:0005004]; transmembrane-ephrin receptor activity [GO:0005005]	axon [GO:0030424]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003]; GPI-linked ephrin receptor activity [GO:0005004]; transmembrane-ephrin receptor activity [GO:0005005]; axon guidance [GO:0007411]; cAMP-mediated signaling [GO:0019933]; ephrin receptor signaling pathway [GO:0048013]; hippocampus development [GO:0021766]; neuron development [GO:0048666]; phosphorylation [GO:0016310]; positive regulation of CREB transcription factor activity [GO:0032793]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of GTPase activity [GO:0043087]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10375373}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P54757}. Cell projection, dendrite {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}.
P54760	reviewed	EPHB4_HUMAN	Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)	EPHB4 HTK MYK1 TYRO11	Homo sapiens (Human)	987	FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}.		angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; ephrin receptor signaling pathway [GO:0048013]; heart morphogenesis [GO:0003007]; protein autophosphorylation [GO:0046777]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; ephrin receptor signaling pathway [GO:0048013]; heart morphogenesis [GO:0003007]; protein autophosphorylation [GO:0046777]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28687708, ECO:0000269|PubMed:8188704}; Single-pass type I membrane protein {ECO:0000269|PubMed:8188704}.
P54762	reviewed	EPHB1_HUMAN	Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)	EPHB1 ELK EPHT2 HEK6 NET	Homo sapiens (Human)	984	FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). {ECO:0000250|UniProtKB:Q8CBF3, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:12925710, ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:9430661, ECO:0000269|PubMed:9499402}.		angiogenesis [GO:0001525]; axon guidance [GO:0007411]; camera-type eye morphogenesis [GO:0048593]; cell chemotaxis [GO:0060326]; cell-substrate adhesion [GO:0031589]; central nervous system projection neuron axonogenesis [GO:0021952]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; ephrin receptor signaling pathway [GO:0048013]; establishment of cell polarity [GO:0030010]; hindbrain tangential cell migration [GO:0021934]; immunological synapse formation [GO:0001771]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; neural precursor cell proliferation [GO:0061351]; neurogenesis [GO:0022008]; optic nerve morphogenesis [GO:0021631]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of JNK cascade [GO:0046328]; retinal ganglion cell axon guidance [GO:0031290]; skeletal muscle satellite cell activation [GO:0014719]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium tip [GO:0032433]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; protein-containing complex binding [GO:0044877]; transmembrane-ephrin receptor activity [GO:0005005]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium tip [GO:0032433]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; protein-containing complex binding [GO:0044877]; transmembrane-ephrin receptor activity [GO:0005005]; angiogenesis [GO:0001525]; axon guidance [GO:0007411]; camera-type eye morphogenesis [GO:0048593]; cell chemotaxis [GO:0060326]; cell-substrate adhesion [GO:0031589]; central nervous system projection neuron axonogenesis [GO:0021952]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; ephrin receptor signaling pathway [GO:0048013]; establishment of cell polarity [GO:0030010]; hindbrain tangential cell migration [GO:0021934]; immunological synapse formation [GO:0001771]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; neural precursor cell proliferation [GO:0061351]; neurogenesis [GO:0022008]; optic nerve morphogenesis [GO:0021631]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of JNK cascade [GO:0046328]; retinal ganglion cell axon guidance [GO:0031290]; skeletal muscle satellite cell activation [GO:0014719]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18034775}; Single-pass type I membrane protein {ECO:0000269|PubMed:18034775}. Early endosome membrane {ECO:0000269|PubMed:18034775}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8CBF3}.
P54764	reviewed	EPHA4_HUMAN	Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)	EPHA4 HEK8 SEK TYRO1	Homo sapiens (Human)	986	FUNCTION: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (By similarity). Phosphorylates CAPRIN1, promoting CAPRIN1-dependent formation of a membraneless compartment (By similarity). {ECO:0000250|UniProtKB:Q03137, ECO:0000269|PubMed:17143272}.		adherens junction organization [GO:0034332]; adult walking behavior [GO:0007628]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to amyloid-beta [GO:1904646]; cochlea development [GO:0090102]; corticospinal tract morphogenesis [GO:0021957]; ephrin receptor signaling pathway [GO:0048013]; fasciculation of motor neuron axon [GO:0097156]; fasciculation of sensory neuron axon [GO:0097155]; glial cell migration [GO:0008347]; motor neuron axon guidance [GO:0008045]; negative regulation of axon regeneration [GO:0048681]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of neuron projection development [GO:0010977]; negative regulation of proteolysis involved in protein catabolic process [GO:1903051]; negative regulation of translation [GO:0017148]; nephric duct morphogenesis [GO:0072178]; neuron projection fasciculation [GO:0106030]; neuron projection guidance [GO:0097485]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001108]; protein autophosphorylation [GO:0046777]; protein stabilization [GO:0050821]; regulation of astrocyte differentiation [GO:0048710]; regulation of axonogenesis [GO:0050770]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; regulation of modification of synaptic structure [GO:1905244]; regulation of synapse pruning [GO:1905806]; synapse pruning [GO:0098883]	adherens junction [GO:0005912]; axon [GO:0030424]; axon terminus [GO:0043679]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrial outer membrane [GO:0005741]; neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]	amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; DH domain binding [GO:0097161]; ephrin receptor binding [GO:0046875]; GPI-linked ephrin receptor activity [GO:0005004]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; PH domain binding [GO:0042731]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase binding [GO:1990782]; transmembrane-ephrin receptor activity [GO:0005005]	adherens junction [GO:0005912]; axon [GO:0030424]; axon terminus [GO:0043679]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrial outer membrane [GO:0005741]; neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; DH domain binding [GO:0097161]; ephrin receptor binding [GO:0046875]; GPI-linked ephrin receptor activity [GO:0005004]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; PH domain binding [GO:0042731]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase binding [GO:1990782]; transmembrane-ephrin receptor activity [GO:0005005]; adherens junction organization [GO:0034332]; adult walking behavior [GO:0007628]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to amyloid-beta [GO:1904646]; cochlea development [GO:0090102]; corticospinal tract morphogenesis [GO:0021957]; ephrin receptor signaling pathway [GO:0048013]; fasciculation of motor neuron axon [GO:0097156]; fasciculation of sensory neuron axon [GO:0097155]; glial cell migration [GO:0008347]; motor neuron axon guidance [GO:0008045]; negative regulation of axon regeneration [GO:0048681]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of neuron projection development [GO:0010977]; negative regulation of proteolysis involved in protein catabolic process [GO:1903051]; negative regulation of translation [GO:0017148]; nephric duct morphogenesis [GO:0072178]; neuron projection fasciculation [GO:0106030]; neuron projection guidance [GO:0097485]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001108]; protein autophosphorylation [GO:0046777]; protein stabilization [GO:0050821]; regulation of astrocyte differentiation [GO:0048710]; regulation of axonogenesis [GO:0050770]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; regulation of modification of synaptic structure [GO:1905244]; regulation of synapse pruning [GO:1905806]; synapse pruning [GO:0098883]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q03137}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q03137}. Cell projection, axon {ECO:0000250|UniProtKB:Q03137}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q03137}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q03137}. Early endosome {ECO:0000250|UniProtKB:Q03137}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q03137}. Note=Clustered upon activation and targeted to early endosome. {ECO:0000250|UniProtKB:Q03137}.
P54802	reviewed	ANAG_HUMAN	Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form]	NAGLU UFHSD1	Homo sapiens (Human)	743	FUNCTION: Involved in the degradation of heparan sulfate.		adult behavior [GO:0030534]; amyloid precursor protein metabolic process [GO:0042982]; aorta morphogenesis [GO:0035909]; astrocyte activation [GO:0048143]; autophagy [GO:0006914]; cardiac muscle cell development [GO:0055013]; cellular lipid catabolic process [GO:0044242]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; cerebellar Purkinje cell layer development [GO:0021680]; collagen metabolic process [GO:0032963]; cone retinal bipolar cell differentiation [GO:1904390]; cytoplasm organization [GO:0007028]; determination of adult lifespan [GO:0008340]; endothelium development [GO:0003158]; exploration behavior [GO:0035640]; ganglioside metabolic process [GO:0001573]; Golgi organization [GO:0007030]; hair follicle morphogenesis [GO:0031069]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparan sulfate proteoglycan metabolic process [GO:0030201]; heparin metabolic process [GO:0030202]; hormone metabolic process [GO:0042445]; inner ear receptor cell development [GO:0060119]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; limb development [GO:0060173]; liver development [GO:0001889]; locomotor rhythm [GO:0045475]; lysosome organization [GO:0007040]; maintenance of blood-brain barrier [GO:0035633]; microglia differentiation [GO:0014004]; microglial cell activation [GO:0001774]; middle ear morphogenesis [GO:0042474]; mitral valve morphogenesis [GO:0003183]; motor behavior [GO:0061744]; multicellular organismal-level iron ion homeostasis [GO:0060586]; nerve development [GO:0021675]; nervous system development [GO:0007399]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein processing [GO:0016485]; receptor signaling pathway via STAT [GO:0097696]; response to disaccharide [GO:0034285]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; retinal rod cell development [GO:0046548]; rod bipolar cell differentiation [GO:1904389]; sequestering of iron ion [GO:0097577]; superoxide metabolic process [GO:0006801]; toll-like receptor 4 signaling pathway [GO:0034142]; vesicle tethering [GO:0099022]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	alpha-N-acetylglucosaminidase activity [GO:0004561]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; alpha-N-acetylglucosaminidase activity [GO:0004561]; adult behavior [GO:0030534]; amyloid precursor protein metabolic process [GO:0042982]; aorta morphogenesis [GO:0035909]; astrocyte activation [GO:0048143]; autophagy [GO:0006914]; cardiac muscle cell development [GO:0055013]; cellular lipid catabolic process [GO:0044242]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; cerebellar Purkinje cell layer development [GO:0021680]; collagen metabolic process [GO:0032963]; cone retinal bipolar cell differentiation [GO:1904390]; cytoplasm organization [GO:0007028]; determination of adult lifespan [GO:0008340]; endothelium development [GO:0003158]; exploration behavior [GO:0035640]; ganglioside metabolic process [GO:0001573]; Golgi organization [GO:0007030]; hair follicle morphogenesis [GO:0031069]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparan sulfate proteoglycan metabolic process [GO:0030201]; heparin metabolic process [GO:0030202]; hormone metabolic process [GO:0042445]; inner ear receptor cell development [GO:0060119]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; limb development [GO:0060173]; liver development [GO:0001889]; locomotor rhythm [GO:0045475]; lysosome organization [GO:0007040]; maintenance of blood-brain barrier [GO:0035633]; microglia differentiation [GO:0014004]; microglial cell activation [GO:0001774]; middle ear morphogenesis [GO:0042474]; mitral valve morphogenesis [GO:0003183]; motor behavior [GO:0061744]; multicellular organismal-level iron ion homeostasis [GO:0060586]; nerve development [GO:0021675]; nervous system development [GO:0007399]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein processing [GO:0016485]; receptor signaling pathway via STAT [GO:0097696]; response to disaccharide [GO:0034285]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; retinal rod cell development [GO:0046548]; rod bipolar cell differentiation [GO:1904389]; sequestering of iron ion [GO:0097577]; superoxide metabolic process [GO:0006801]; toll-like receptor 4 signaling pathway [GO:0034142]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Lysosome.
P54803	reviewed	GALC_HUMAN	Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactocerebroside beta-galactosidase) (Galactosylceramidase) (Galactosylceramide beta-galactosidase)	GALC	Homo sapiens (Human)	685	FUNCTION: Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine (PubMed:8281145, PubMed:8399327). Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (PubMed:8281145, PubMed:8399327). {ECO:0000269|PubMed:8281145, ECO:0000269|PubMed:8399327}.		galactosylceramide catabolic process [GO:0006683]; glycosphingolipid metabolic process [GO:0006687]; myelination [GO:0042552]	lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	galactosylceramidase activity [GO:0004336]	lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; galactosylceramidase activity [GO:0004336]; galactosylceramide catabolic process [GO:0006683]; glycosphingolipid metabolic process [GO:0006687]; myelination [GO:0042552]	SUBCELLULAR LOCATION: Lysosome.
P54819	reviewed	KAD2_HUMAN	Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]	AK2 ADK2	Homo sapiens (Human)	239	FUNCTION: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:19043416}.		ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; nucleobase-containing small molecule interconversion [GO:0015949]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; sperm mitochondrial sheath [GO:0097226]	adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; sperm mitochondrial sheath [GO:0097226]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; nucleobase-containing small molecule interconversion [GO:0015949]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03168}.
P54821	reviewed	PRRX1_HUMAN	Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1)	PRRX1 PMX1	Homo sapiens (Human)	245	FUNCTION: Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). {ECO:0000250}.		artery morphogenesis [GO:0048844]; cartilage development [GO:0051216]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; inner ear morphogenesis [GO:0042472]; mesenchymal cell proliferation [GO:0010463]; middle ear morphogenesis [GO:0042474]; neuron fate determination [GO:0048664]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron projection regeneration [GO:0070570]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; smoothened signaling pathway [GO:0007224]; stem cell proliferation [GO:0072089]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; artery morphogenesis [GO:0048844]; cartilage development [GO:0051216]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; inner ear morphogenesis [GO:0042472]; mesenchymal cell proliferation [GO:0010463]; middle ear morphogenesis [GO:0042474]; neuron fate determination [GO:0048664]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron projection regeneration [GO:0070570]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; smoothened signaling pathway [GO:0007224]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Nucleus.
P54829	reviewed	PTN5_HUMAN	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP)	PTPN5	Homo sapiens (Human)	565	FUNCTION: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. {ECO:0000269|PubMed:21777200}.		protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	cell junction [GO:0030054]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]	cell junction [GO:0030054]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
P54840	reviewed	GYS2_HUMAN	Glycogen [starch] synthase, liver (EC 2.4.1.11)	GYS2	Homo sapiens (Human)	703	FUNCTION: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.		generation of precursor metabolites and energy [GO:0006091]; glycogen biosynthetic process [GO:0005978]; response to glucose [GO:0009749]	cell cortex [GO:0005938]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; ectoplasm [GO:0043265]	glycogen (starch) synthase activity [GO:0004373]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547]	cell cortex [GO:0005938]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; ectoplasm [GO:0043265]; glycogen (starch) synthase activity [GO:0004373]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547]; generation of precursor metabolites and energy [GO:0006091]; glycogen biosynthetic process [GO:0005978]; response to glucose [GO:0009749]	
P54845	reviewed	NRL_HUMAN	Neural retina-specific leucine zipper protein (NRL)	NRL D14S46E	Homo sapiens (Human)	237	FUNCTION: Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001). {ECO:0000269|PubMed:17335001, ECO:0000269|PubMed:21981118}.		positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to stimulus [GO:0050896]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; leucine zipper domain binding [GO:0043522]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; leucine zipper domain binding [GO:0043522]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to stimulus [GO:0050896]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11477108}. Nucleus {ECO:0000269|PubMed:11477108, ECO:0000269|PubMed:17335001}.
P54849	reviewed	EMP1_HUMAN	Epithelial membrane protein 1 (EMP-1) (CL-20) (Protein B4B) (Tumor-associated membrane protein)	EMP1 B4B TMP	Homo sapiens (Human)	157			apoptotic process [GO:0006915]; bleb assembly [GO:0032060]; epidermis development [GO:0008544]	membrane [GO:0016020]; plasma membrane [GO:0005886]		membrane [GO:0016020]; plasma membrane [GO:0005886]; apoptotic process [GO:0006915]; bleb assembly [GO:0032060]; epidermis development [GO:0008544]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P54851	reviewed	EMP2_HUMAN	Epithelial membrane protein 2 (EMP-2) (Protein XMP)	EMP2 XMP	Homo sapiens (Human)	167	FUNCTION: Functions as a key regulator of cell membrane composition by regulating protein surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation (By similarity). Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration and cell contraction through PTK2 and SRC activation (PubMed:21637765, PubMed:22728127). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PubMed:19494199). Positively regulates cell proliferation (PubMed:24814193). Plays a role during cell death and cell blebbing (PubMed:12107182). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PubMed:23334331). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16487956). Plays a role in placental angiogenesis and uterine natural killer cell regulation at the maternal-fetal placental interface, however not required in the maternal tissues for a viable pregnancy (By similarity). Involved in the early stages of embryogenic development and cardiogenesis, potentially via regulation of epithelial-mesenchymal transition timing (By similarity). May play a role in glomerular filtration (By similarity). {ECO:0000250|UniProtKB:F1QIK8, ECO:0000250|UniProtKB:O88662, ECO:0000269|PubMed:12107182, ECO:0000269|PubMed:16216233, ECO:0000269|PubMed:16487956, ECO:0000269|PubMed:19494199, ECO:0000269|PubMed:21637765, ECO:0000269|PubMed:22728127, ECO:0000269|PubMed:23334331, ECO:0000269|PubMed:23439602, ECO:0000269|PubMed:24814193}.		actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; bleb assembly [GO:0032060]; blood vessel endothelial cell migration [GO:0043534]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; early endosome to late endosome transport [GO:0045022]; embryo implantation [GO:0007566]; embryonic process involved in female pregnancy [GO:0060136]; heart formation [GO:0060914]; membrane raft assembly [GO:0001765]; natural killer cell proliferation [GO:0001787]; neutrophil migration [GO:1990266]; plasma membrane raft assembly [GO:0044854]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; protein localization to cell surface [GO:0034394]; protein localization to plasma membrane [GO:0072659]; regulation of angiogenesis [GO:0045765]; regulation of cell-matrix adhesion [GO:0001952]; regulation of endothelial cell migration [GO:0010594]; regulation of glomerular filtration [GO:0003093]; regulation of kinase activity [GO:0043549]; regulation of vasculogenesis [GO:2001212]; T cell mediated cytotoxicity [GO:0001913]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901]; actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; bleb assembly [GO:0032060]; blood vessel endothelial cell migration [GO:0043534]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; early endosome to late endosome transport [GO:0045022]; embryo implantation [GO:0007566]; embryonic process involved in female pregnancy [GO:0060136]; heart formation [GO:0060914]; membrane raft assembly [GO:0001765]; natural killer cell proliferation [GO:0001787]; neutrophil migration [GO:1990266]; plasma membrane raft assembly [GO:0044854]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; protein localization to cell surface [GO:0034394]; protein localization to plasma membrane [GO:0072659]; regulation of angiogenesis [GO:0045765]; regulation of cell-matrix adhesion [GO:0001952]; regulation of endothelial cell migration [GO:0010594]; regulation of glomerular filtration [GO:0003093]; regulation of kinase activity [GO:0043549]; regulation of vasculogenesis [GO:2001212]; T cell mediated cytotoxicity [GO:0001913]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:18400107}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:12107182, ECO:0000269|PubMed:18400107, ECO:0000269|PubMed:21637765, ECO:0000269|PubMed:28295343}. Apical cell membrane {ECO:0000250|UniProtKB:O88662}. Membrane raft {ECO:0000269|PubMed:21637765}. Cytoplasm {ECO:0000269|PubMed:21637765}. Nucleus {ECO:0000250|UniProtKB:Q66HH2}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O88662}. Note=Localizes in cytoplasm, foot processes and cell bodies of podocytes and nucleus of endothelial cells of kidney. Localizes to the apical cell surface in the luminal epithelium and glandular epithelium. Colocalized with ITGB1 and GPI-anchor proteins on plasma membrane. {ECO:0000250|UniProtKB:O88662, ECO:0000250|UniProtKB:Q66HH2}.
P54852	reviewed	EMP3_HUMAN	Epithelial membrane protein 3 (EMP-3) (Hematopoietic neural membrane protein 1) (HNMP-1) (Protein YMP)	EMP3 YMP	Homo sapiens (Human)	163	FUNCTION: Probably involved in cell proliferation and cell-cell interactions.		apoptotic process [GO:0006915]; bleb assembly [GO:0032060]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; apoptotic process [GO:0006915]; bleb assembly [GO:0032060]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P54855	reviewed	UDB15_HUMAN	UDP-glucuronosyltransferase 2B15 (UDPGT 2B15) (UGT2B15) (EC 2.4.1.17) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3)	UGT2B15 UGT2B8	Homo sapiens (Human)	530	FUNCTION: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:7835232, PubMed:9295060, PubMed:16595710, PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:7835232). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:7835232, PubMed:9295060, PubMed:16595710, PubMed:18719240, PubMed:23288867). Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins) (PubMed:7835232). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (By similarity). {ECO:0000250|UniProtKB:P36511, ECO:0000269|PubMed:16595710, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:7835232, ECO:0000269|PubMed:9295060}.		cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]	glucuronosyltransferase activity [GO:0015020]	endoplasmic reticulum membrane [GO:0005789]; glucuronosyltransferase activity [GO:0015020]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:23288867}; Single-pass membrane protein {ECO:0000255}.
P54868	reviewed	HMCS2_HUMAN	Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)	HMGCS2	Homo sapiens (Human)	508	FUNCTION: Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. {ECO:0000269|PubMed:11228257, ECO:0000269|PubMed:23751782, ECO:0000269|PubMed:29597274}.		acetyl-CoA metabolic process [GO:0006084]; adipose tissue development [GO:0060612]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fatty acid [GO:0071398]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; ketone body biosynthetic process [GO:0046951]; kidney development [GO:0001822]; liver development [GO:0001889]; lung development [GO:0030324]; midgut development [GO:0007494]; multicellular organismal response to stress [GO:0033555]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to growth hormone [GO:0060416]; response to linoleic acid [GO:0070543]; response to metal ion [GO:0010038]; response to monosaccharide [GO:0034284]; response to nutrient [GO:0007584]; response to prostaglandin F [GO:0034696]; response to starvation [GO:0042594]; response to temperature stimulus [GO:0009266]; response to testosterone [GO:0033574]; response to triglyceride [GO:0034014]; response to xenobiotic stimulus [GO:0009410]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	hydroxymethylglutaryl-CoA synthase activity [GO:0004421]; identical protein binding [GO:0042802]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; hydroxymethylglutaryl-CoA synthase activity [GO:0004421]; identical protein binding [GO:0042802]; acetyl-CoA metabolic process [GO:0006084]; adipose tissue development [GO:0060612]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fatty acid [GO:0071398]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; ketone body biosynthetic process [GO:0046951]; kidney development [GO:0001822]; liver development [GO:0001889]; lung development [GO:0030324]; midgut development [GO:0007494]; multicellular organismal response to stress [GO:0033555]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to growth hormone [GO:0060416]; response to linoleic acid [GO:0070543]; response to metal ion [GO:0010038]; response to monosaccharide [GO:0034284]; response to nutrient [GO:0007584]; response to prostaglandin F [GO:0034696]; response to starvation [GO:0042594]; response to temperature stimulus [GO:0009266]; response to testosterone [GO:0033574]; response to triglyceride [GO:0034014]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P22791}.
P54886	reviewed	P5CS_HUMAN	Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]	ALDH18A1 GSAS P5CS PYCS	Homo sapiens (Human)	795	FUNCTION: Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. {ECO:0000269|PubMed:10037775, ECO:0000269|PubMed:11092761, ECO:0000269|PubMed:26297558, ECO:0000269|PubMed:26320891}.		citrulline biosynthetic process [GO:0019240]; glutamate metabolic process [GO:0006536]; L-proline biosynthetic process [GO:0055129]; ornithine biosynthetic process [GO:0006592]; phosphorylation [GO:0016310]; proline biosynthetic process [GO:0006561]; response to temperature stimulus [GO:0009266]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; glutamate 5-kinase activity [GO:0004349]; glutamate-5-semialdehyde dehydrogenase activity [GO:0004350]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; glutamate 5-kinase activity [GO:0004349]; glutamate-5-semialdehyde dehydrogenase activity [GO:0004350]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; citrulline biosynthetic process [GO:0019240]; glutamate metabolic process [GO:0006536]; L-proline biosynthetic process [GO:0055129]; ornithine biosynthetic process [GO:0006592]; phosphorylation [GO:0016310]; proline biosynthetic process [GO:0006561]; response to temperature stimulus [GO:0009266]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:26297558, ECO:0000269|PubMed:26320891}.
P54920	reviewed	SNAA_HUMAN	Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)	NAPA SNAPA	Homo sapiens (Human)	295	FUNCTION: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}.		apical protein localization [GO:0045176]; brain development [GO:0007420]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; neuron differentiation [GO:0030182]; regulation of synaptic vesicle priming [GO:0010807]; SNARE complex disassembly [GO:0035494]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle priming [GO:0016082]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]	protein-containing complex binding [GO:0044877]; SNARE binding [GO:0000149]; soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]; protein-containing complex binding [GO:0044877]; SNARE binding [GO:0000149]; soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905]; apical protein localization [GO:0045176]; brain development [GO:0007420]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; neuron differentiation [GO:0030182]; regulation of synaptic vesicle priming [GO:0010807]; SNARE complex disassembly [GO:0035494]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle priming [GO:0016082]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15980433}; Peripheral membrane protein {ECO:0000305|PubMed:15029241}.
P54922	reviewed	ADPRH_HUMAN	ADP-ribosylhydrolase ARH1 (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ([Protein ADP-ribosylarginine] hydrolase) (ADP-ribosylarginine hydrolase) (hARH1)	ADPRH ARH1	Homo sapiens (Human)	357	FUNCTION: Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. {ECO:0000269|PubMed:30472116, ECO:0000269|PubMed:8349667}.		protein de-ADP-ribosylation [GO:0051725]; protein modification process [GO:0036211]	extracellular space [GO:0005615]	ADP-ribosylarginine hydrolase activity [GO:0003875]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]	extracellular space [GO:0005615]; ADP-ribosylarginine hydrolase activity [GO:0003875]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; protein de-ADP-ribosylation [GO:0051725]; protein modification process [GO:0036211]	
P55000	reviewed	SLUR1_HUMAN	Secreted Ly-6/uPAR-related protein 1 (SLURP-1) (ARS component B) (ARS(component B)-81/S) (Anti-neoplastic urinary protein) (ANUP)	SLURP1 ARS	Homo sapiens (Human)	103	FUNCTION: Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have an immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896). {ECO:0000250|UniProtKB:Q9Z0K7, ECO:0000269|PubMed:14506129, ECO:0000269|PubMed:17286989, ECO:0000269|PubMed:26905431, ECO:0000269|PubMed:8742060, ECO:0000305|PubMed:14721776, ECO:0000305|PubMed:17008884}.		cell activation [GO:0001775]; cell adhesion [GO:0007155]; locomotory behavior [GO:0007626]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; neuromuscular process controlling posture [GO:0050884]; urokinase plasminogen activator signaling pathway [GO:0038195]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	acetylcholine receptor activator activity [GO:0030549]; cytokine activity [GO:0005125]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; acetylcholine receptor activator activity [GO:0030549]; cytokine activity [GO:0005125]; cell activation [GO:0001775]; cell adhesion [GO:0007155]; locomotory behavior [GO:0007626]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; neuromuscular process controlling posture [GO:0050884]; urokinase plasminogen activator signaling pathway [GO:0038195]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14506129, ECO:0000269|PubMed:25919322, ECO:0000269|PubMed:26905431}.
P55001	reviewed	MFAP2_HUMAN	Microfibrillar-associated protein 2 (MFAP-2) (Microfibril-associated glycoprotein 1) (MAGP) (MAGP-1)	MFAP2 MAGP1	Homo sapiens (Human)	183	FUNCTION: Component of the elastin-associated microfibrils.		embryonic eye morphogenesis [GO:0048048]; positive regulation of cold-induced thermogenesis [GO:0120162]; post-embryonic eye morphogenesis [GO:0048050]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; microfibril [GO:0001527]		collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; microfibril [GO:0001527]; embryonic eye morphogenesis [GO:0048048]; positive regulation of cold-induced thermogenesis [GO:0120162]; post-embryonic eye morphogenesis [GO:0048050]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
P55008	reviewed	AIF1_HUMAN	Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (Protein G1)	AIF1 G1 IBA1	Homo sapiens (Human)	147	FUNCTION: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. {ECO:0000269|PubMed:15117732, ECO:0000269|PubMed:16049345, ECO:0000269|PubMed:18699778}.		actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin filament polymerization [GO:0030041]; cellular response to oxidative stress [GO:0034599]; cellular response to type II interferon [GO:0071346]; inflammatory response [GO:0006954]; microglial cell activation [GO:0001774]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell proliferation [GO:0048662]; parallel actin filament bundle assembly [GO:0030046]; phagocytosis, engulfment [GO:0006911]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of chemotaxis [GO:0050921]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; Rac protein signal transduction [GO:0016601]; regulation of gene expression [GO:0010468]; ruffle assembly [GO:0097178]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cell projection [GO:0097386]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cell projection [GO:0097386]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin filament polymerization [GO:0030041]; cellular response to oxidative stress [GO:0034599]; cellular response to type II interferon [GO:0071346]; inflammatory response [GO:0006954]; microglial cell activation [GO:0001774]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell proliferation [GO:0048662]; parallel actin filament bundle assembly [GO:0030046]; phagocytosis, engulfment [GO:0006911]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of chemotaxis [GO:0050921]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; Rac protein signal transduction [GO:0016601]; regulation of gene expression [GO:0010468]; ruffle assembly [GO:0097178]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70200}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O70200}; Peripheral membrane protein {ECO:0000250|UniProtKB:O70200}; Cytoplasmic side {ECO:0000250|UniProtKB:O70200}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70200}. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. {ECO:0000250|UniProtKB:O70200}.
P55010	reviewed	IF5_HUMAN	Eukaryotic translation initiation factor 5 (eIF-5)	EIF5	Homo sapiens (Human)	431	FUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}.		formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; ribosome assembly [GO:0042255]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; synapse [GO:0045202]	cadherin binding [GO:0045296]; eukaryotic initiation factor eIF2 binding [GO:0071074]; GDP-dissociation inhibitor activity [GO:0005092]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; synapse [GO:0045202]; cadherin binding [GO:0045296]; eukaryotic initiation factor eIF2 binding [GO:0071074]; GDP-dissociation inhibitor activity [GO:0005092]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; ribosome assembly [GO:0042255]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P55011	reviewed	S12A2_HUMAN	Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2)	SLC12A2 NKCC1	Homo sapiens (Human)	1212	FUNCTION: Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:32081947, PubMed:33597714, PubMed:32294086, PubMed:7629105, PubMed:16669787). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:32081947, PubMed:32294086, PubMed:7629105, PubMed:16669787). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:7629105}.		ammonium transmembrane transport [GO:0072488]; cell volume homeostasis [GO:0006884]; cellular response to chemokine [GO:1990869]; cellular response to potassium ion [GO:0035865]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; hyperosmotic response [GO:0006972]; inorganic anion import across plasma membrane [GO:0098658]; inorganic cation import across plasma membrane [GO:0098659]; intracellular chloride ion homeostasis [GO:0030644]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; maintenance of blood-brain barrier [GO:0035633]; monoatomic ion transport [GO:0006811]; negative regulation of vascular wound healing [GO:0061044]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of cell volume [GO:0045795]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; regulation of matrix metallopeptidase secretion [GO:1904464]; regulation of spontaneous synaptic transmission [GO:0150003]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; T cell chemotaxis [GO:0010818]; transepithelial ammonium transport [GO:0070634]; transepithelial chloride transport [GO:0030321]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell body membrane [GO:0044298]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cell projection membrane [GO:0031253]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	ammonium transmembrane transporter activity [GO:0008519]; chloride:monoatomic cation symporter activity [GO:0015377]; Hsp90 protein binding [GO:0051879]; metal ion transmembrane transporter activity [GO:0046873]; potassium ion transmembrane transporter activity [GO:0015079]; protein kinase binding [GO:0019901]; protein-folding chaperone binding [GO:0051087]; sodium:potassium:chloride symporter activity [GO:0008511]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell body membrane [GO:0044298]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cell projection membrane [GO:0031253]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; ammonium transmembrane transporter activity [GO:0008519]; chloride:monoatomic cation symporter activity [GO:0015377]; Hsp90 protein binding [GO:0051879]; metal ion transmembrane transporter activity [GO:0046873]; potassium ion transmembrane transporter activity [GO:0015079]; protein kinase binding [GO:0019901]; protein-folding chaperone binding [GO:0051087]; sodium:potassium:chloride symporter activity [GO:0008511]; ammonium transmembrane transport [GO:0072488]; cell volume homeostasis [GO:0006884]; cellular response to chemokine [GO:1990869]; cellular response to potassium ion [GO:0035865]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; hyperosmotic response [GO:0006972]; inorganic anion import across plasma membrane [GO:0098658]; inorganic cation import across plasma membrane [GO:0098659]; intracellular chloride ion homeostasis [GO:0030644]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; maintenance of blood-brain barrier [GO:0035633]; monoatomic ion transport [GO:0006811]; negative regulation of vascular wound healing [GO:0061044]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of cell volume [GO:0045795]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; regulation of matrix metallopeptidase secretion [GO:1904464]; regulation of spontaneous synaptic transmission [GO:0150003]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; T cell chemotaxis [GO:0010818]; transepithelial ammonium transport [GO:0070634]; transepithelial chloride transport [GO:0030321]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:7629105}; Multi-pass membrane protein {ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714}.
P55017	reviewed	S12A3_HUMAN	Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter)	SLC12A3 NCC TSC	Homo sapiens (Human)	1021	FUNCTION: Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:21613606, PubMed:18270262, PubMed:22009145, PubMed:36351028, PubMed:36792826). Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (By similarity). May act either independently of IL18R1, or in a complex with IL18R1 (By similarity). {ECO:0000250|UniProtKB:P59158, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22009145, ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826}.		cell volume homeostasis [GO:0006884]; cellular response to inorganic substance [GO:0071241]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; renal sodium ion absorption [GO:0070294]; response to aldosterone [GO:1904044]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion homeostasis [GO:0055078]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; sodium:chloride symporter activity [GO:0015378]; sodium:potassium:chloride symporter activity [GO:0008511]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; sodium:chloride symporter activity [GO:0015378]; sodium:potassium:chloride symporter activity [GO:0008511]; cell volume homeostasis [GO:0006884]; cellular response to inorganic substance [GO:0071241]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; renal sodium ion absorption [GO:0070294]; response to aldosterone [GO:1904044]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion homeostasis [GO:0055078]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22009145, ECO:0000269|PubMed:36370249}; Multi-pass membrane protein {ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826}. Apical cell membrane {ECO:0000250|UniProtKB:P59158}; Multi-pass membrane protein {ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826}.
P55036	reviewed	PSMD4_HUMAN	26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)	PSMD4 MCB1	Homo sapiens (Human)	377	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}.	MISCELLANEOUS: [Isoform Rpn10E]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]	identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	
P55039	reviewed	DRG2_HUMAN	Developmentally-regulated GTP-binding protein 2 (DRG-2) (Translation factor GTPase DRG2) (TRAFAC GTPase DRG2) (EC 3.6.5.-)	DRG2	Homo sapiens (Human)	364	FUNCTION: Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. {ECO:0000269|PubMed:29915238}.		cytoplasmic translation [GO:0002181]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; cytoplasmic translation [GO:0002181]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29915238}. Cytoplasm {ECO:0000269|PubMed:29915238}.
P55040	reviewed	GEM_HUMAN	GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR)	GEM KIR	Homo sapiens (Human)	296	FUNCTION: Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.		cell surface receptor signaling pathway [GO:0007166]; chromosome organization [GO:0051276]; immune response [GO:0006955]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; signal transduction [GO:0007165]	cytoplasmic side of plasma membrane [GO:0009898]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle midzone [GO:0051233]	calcium channel regulator activity [GO:0005246]; calmodulin binding [GO:0005516]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	cytoplasmic side of plasma membrane [GO:0009898]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle midzone [GO:0051233]; calcium channel regulator activity [GO:0005246]; calmodulin binding [GO:0005516]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; cell surface receptor signaling pathway [GO:0007166]; chromosome organization [GO:0051276]; immune response [GO:0006955]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
P55042	reviewed	RAD_HUMAN	GTP-binding protein RAD (RAD1) (Ras associated with diabetes)	RRAD RAD	Homo sapiens (Human)	308	FUNCTION: May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents (By similarity). Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway (PubMed:18056528). Inhibits phosphorylation and activation of CAMK2D (PubMed:18056528). {ECO:0000250|UniProtKB:O88667, ECO:0000269|PubMed:18056528}.		small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	calcium channel regulator activity [GO:0005246]; calmodulin binding [GO:0005516]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; calcium channel regulator activity [GO:0005246]; calmodulin binding [GO:0005516]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
P55055	reviewed	NR1H2_HUMAN	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor)	NR1H2 LXRB NER UNR	Homo sapiens (Human)	460	FUNCTION: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). {ECO:0000250|UniProtKB:Q60644, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:25661920}.		cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; hormone-mediated signaling pathway [GO:0009755]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of lipid transport [GO:0032369]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of pinocytosis [GO:0048550]; negative regulation of proteolysis [GO:0045861]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; positive regulation of lipid storage [GO:0010884]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of pancreatic juice secretion [GO:0090187]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of secretion of lysosomal enzymes [GO:0090340]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	apolipoprotein A-I receptor binding [GO:0034191]; ATPase binding [GO:0051117]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; apolipoprotein A-I receptor binding [GO:0034191]; ATPase binding [GO:0051117]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; hormone-mediated signaling pathway [GO:0009755]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of lipid transport [GO:0032369]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of pinocytosis [GO:0048550]; negative regulation of proteolysis [GO:0045861]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; positive regulation of lipid storage [GO:0010884]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of pancreatic juice secretion [GO:0090187]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of secretion of lysosomal enzymes [GO:0090340]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
P55056	reviewed	APOC4_HUMAN	Apolipoprotein C-IV (Apo-CIV) (ApoC-IV) (Apolipoprotein C4)	APOC4	Homo sapiens (Human)	127	FUNCTION: May participate in lipoprotein metabolism.		lipid metabolic process [GO:0006629]; positive regulation of sequestering of triglyceride [GO:0010890]; triglyceride homeostasis [GO:0070328]	extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; very-low-density lipoprotein particle [GO:0034361]	lipid transporter activity [GO:0005319]	extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; very-low-density lipoprotein particle [GO:0034361]; lipid transporter activity [GO:0005319]; lipid metabolic process [GO:0006629]; positive regulation of sequestering of triglyceride [GO:0010890]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Secreted.
P55058	reviewed	PLTP_HUMAN	Phospholipid transfer protein (Lipid transfer protein II)	PLTP	Homo sapiens (Human)	493	FUNCTION: Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves (PubMed:7654777, PubMed:9132017, PubMed:11013307, PubMed:19321130, PubMed:21515415, PubMed:29883800). Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine (PubMed:9132017). Plays an important role in HDL remodeling which involves modulating the size and composition of HDL (PubMed:29883800). Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion (PubMed:21736953). Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability (PubMed:11013307). {ECO:0000269|PubMed:11013307, ECO:0000269|PubMed:19321130, ECO:0000269|PubMed:21515415, ECO:0000269|PubMed:29883800, ECO:0000269|PubMed:7654777, ECO:0000269|PubMed:9132017, ECO:0000303|PubMed:21736953}.		ceramide transport [GO:0035627]; flagellated sperm motility [GO:0030317]; glycolipid transport [GO:0046836]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; vitamin E biosynthetic process [GO:0010189]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; nucleus [GO:0005634]	ceramide binding [GO:0097001]; ceramide transfer activity [GO:0120017]; cerebroside transfer activity [GO:0140340]; cholesterol transfer activity [GO:0120020]; diacylglyceride transfer activity [GO:0140337]; diacylglycerol binding [GO:0019992]; high-density lipoprotein particle binding [GO:0008035]; low-density lipoprotein particle binding [GO:0030169]; phosphatidic acid binding [GO:0070300]; phosphatidic acid transfer activity [GO:1990050]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylethanolamine transfer activity [GO:1904121]; phosphatidylglycerol binding [GO:1901611]; phosphatidylglycerol transfer activity [GO:0140339]; phosphatidylinositol transfer activity [GO:0008526]; phospholipid transfer activity [GO:0120014]; sphingomyelin transfer activity [GO:0140338]; very-low-density lipoprotein particle binding [GO:0034189]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; nucleus [GO:0005634]; ceramide binding [GO:0097001]; ceramide transfer activity [GO:0120017]; cerebroside transfer activity [GO:0140340]; cholesterol transfer activity [GO:0120020]; diacylglyceride transfer activity [GO:0140337]; diacylglycerol binding [GO:0019992]; high-density lipoprotein particle binding [GO:0008035]; low-density lipoprotein particle binding [GO:0030169]; phosphatidic acid binding [GO:0070300]; phosphatidic acid transfer activity [GO:1990050]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylethanolamine transfer activity [GO:1904121]; phosphatidylglycerol binding [GO:1901611]; phosphatidylglycerol transfer activity [GO:0140339]; phosphatidylinositol transfer activity [GO:0008526]; phospholipid transfer activity [GO:0120014]; sphingomyelin transfer activity [GO:0140338]; very-low-density lipoprotein particle binding [GO:0034189]; ceramide transport [GO:0035627]; flagellated sperm motility [GO:0030317]; glycolipid transport [GO:0046836]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; vitamin E biosynthetic process [GO:0010189]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19321130}. Nucleus {ECO:0000269|PubMed:19321130}. Note=Nuclear export is XPO1/CRM1-dependent. {ECO:0000269|PubMed:19321130}.
P55060	reviewed	XPO2_HUMAN	Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)	CSE1L CAS XPO2	Homo sapiens (Human)	971	FUNCTION: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:9323134}.		protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9323134}. Nucleus {ECO:0000269|PubMed:9323134}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:9323134}.
P55061	reviewed	BI1_HUMAN	Bax inhibitor 1 (BI-1) (Testis-enhanced gene transcript protein) (Transmembrane BAX inhibitor motif-containing protein 6)	TMBIM6 BI1 TEGT	Homo sapiens (Human)	237	FUNCTION: Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity). {ECO:0000250|UniProtKB:Q9D2C7, ECO:0000269|PubMed:21075086, ECO:0000269|PubMed:22128171}.		autophagy [GO:0006914]; cellular response to unfolded protein [GO:0034620]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoribonuclease activity [GO:0060702]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of protein binding [GO:0032091]; negative regulation of RNA splicing [GO:0033119]; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990441]; neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0036483]; response to L-glutamate [GO:1902065]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	endoribonuclease inhibitor activity [GO:0060698]; enzyme binding [GO:0019899]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; endoribonuclease inhibitor activity [GO:0060698]; enzyme binding [GO:0019899]; ubiquitin protein ligase binding [GO:0031625]; autophagy [GO:0006914]; cellular response to unfolded protein [GO:0034620]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoribonuclease activity [GO:0060702]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of protein binding [GO:0032091]; negative regulation of RNA splicing [GO:0033119]; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990441]; neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0036483]; response to L-glutamate [GO:1902065]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21075086, ECO:0000269|PubMed:22128171}; Multi-pass membrane protein {ECO:0000269|PubMed:21075086, ECO:0000269|PubMed:22128171}.
P55064	reviewed	AQP5_HUMAN	Aquaporin-5 (AQP-5)	AQP5	Homo sapiens (Human)	265	FUNCTION: Forms a water-specific channel (PubMed:8621489, PubMed:18768791). Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). {ECO:0000250|UniProtKB:Q9WTY4, ECO:0000269|PubMed:16571723, ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:8621489}.		camera-type eye morphogenesis [GO:0048593]; carbon dioxide transport [GO:0015670]; cellular hypotonic response [GO:0071476]; odontogenesis [GO:0042476]; pancreatic juice secretion [GO:0030157]; protein homotetramerization [GO:0051289]; saliva secretion [GO:0046541]; water transport [GO:0006833]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; water channel activity [GO:0015250]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; water channel activity [GO:0015250]; camera-type eye morphogenesis [GO:0048593]; carbon dioxide transport [GO:0015670]; cellular hypotonic response [GO:0071476]; odontogenesis [GO:0042476]; pancreatic juice secretion [GO:0030157]; protein homotetramerization [GO:0051289]; saliva secretion [GO:0046541]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:23473857}; Multi-pass membrane protein {ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106}. Cell membrane {ECO:0000269|PubMed:23830519, ECO:0000269|PubMed:26569106, ECO:0000269|PubMed:8621489}; Multi-pass membrane protein {ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:26569106}; Multi-pass membrane protein {ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106}. Note=Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane. {ECO:0000269|PubMed:26569106}.
P55072	reviewed	TERA_HUMAN	Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)	VCP HEL-220 HEL-S-70	Homo sapiens (Human)	806	FUNCTION: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042607, PubMed:23042605). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; aggresome assembly [GO:0070842]; ATP metabolic process [GO:0046034]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum unfolded protein response [GO:0030968]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ER-associated misfolded protein catabolic process [GO:0071712]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; flavin adenine dinucleotide catabolic process [GO:0072389]; interstrand cross-link repair [GO:0036297]; macroautophagy [GO:0016236]; mitotic spindle disassembly [GO:0051228]; NADH metabolic process [GO:0006734]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Lys63-specific deubiquitinase activity [GO:1903007]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; positive regulation of protein-containing complex assembly [GO:0031334]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of protein localization to chromatin [GO:1905634]; regulation of synapse organization [GO:0050807]; retrograde protein transport, ER to cytosol [GO:0030970]; stress granule disassembly [GO:0035617]; translesion synthesis [GO:0019985]; ubiquitin-dependent ERAD pathway [GO:0030433]; viral genome replication [GO:0019079]	ATPase complex [GO:1904949]; azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; site of double-strand break [GO:0035861]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; VCP-NSFL1C complex [GO:1990730]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; BAT3 complex binding [GO:1904288]; deubiquitinase activator activity [GO:0035800]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; lipid binding [GO:0008289]; MHC class I protein binding [GO:0042288]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-dependent protein binding [GO:0140036]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-specific protease binding [GO:1990381]	ATPase complex [GO:1904949]; azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; site of double-strand break [GO:0035861]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; VCP-NSFL1C complex [GO:1990730]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; BAT3 complex binding [GO:1904288]; deubiquitinase activator activity [GO:0035800]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; lipid binding [GO:0008289]; MHC class I protein binding [GO:0042288]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-dependent protein binding [GO:0140036]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-specific protease binding [GO:1990381]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; aggresome assembly [GO:0070842]; ATP metabolic process [GO:0046034]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum unfolded protein response [GO:0030968]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ER-associated misfolded protein catabolic process [GO:0071712]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; flavin adenine dinucleotide catabolic process [GO:0072389]; interstrand cross-link repair [GO:0036297]; macroautophagy [GO:0016236]; mitotic spindle disassembly [GO:0051228]; NADH metabolic process [GO:0006734]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Lys63-specific deubiquitinase activity [GO:1903007]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; positive regulation of protein-containing complex assembly [GO:0031334]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of protein localization to chromatin [GO:1905634]; regulation of synapse organization [GO:0050807]; retrograde protein transport, ER to cytosol [GO:0030970]; stress granule disassembly [GO:0035617]; translesion synthesis [GO:0019985]; ubiquitin-dependent ERAD pathway [GO:0030433]; viral genome replication [GO:0019079]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15456787}. Endoplasmic reticulum {ECO:0000269|PubMed:15215856}. Nucleus {ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:26842564}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29804830}. Note=Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients (PubMed:15456787). Present in the Lewy bodies specifically found in neurons from Parkinson disease patients (PubMed:15456787). Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78 (PubMed:16168377). Following DNA double-strand breaks, recruited to the sites of damage (PubMed:22120668). Recruited to stalled replication forks via interaction with SPRTN (PubMed:23042605). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622). Colocalizes with TIA1, ZFAND1 and G3BP1 in cytoplasmic stress granules (SGs) in response to arsenite-induced stress treatment (PubMed:29804830). {ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830}.
P55073	reviewed	IOD3_HUMAN	Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase)	DIO3 ITDI3 TXDI3	Homo sapiens (Human)	304	FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. {ECO:0000269|PubMed:7593630}.		brown fat cell proliferation [GO:0070342]; hormone biosynthetic process [GO:0042446]; positive regulation of multicellular organism growth [GO:0040018]; response to hypoxia [GO:0001666]; retinal cone cell apoptotic process [GO:0097474]; retinal cone cell development [GO:0046549]; thyroid hormone catabolic process [GO:0042404]; thyroid hormone metabolic process [GO:0042403]	endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	thyroxine 5'-deiodinase activity [GO:0004800]; thyroxine 5-deiodinase activity [GO:0033798]	endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; thyroxine 5'-deiodinase activity [GO:0004800]; thyroxine 5-deiodinase activity [GO:0033798]; brown fat cell proliferation [GO:0070342]; hormone biosynthetic process [GO:0042446]; positive regulation of multicellular organism growth [GO:0040018]; response to hypoxia [GO:0001666]; retinal cone cell apoptotic process [GO:0097474]; retinal cone cell development [GO:0046549]; thyroid hormone catabolic process [GO:0042404]; thyroid hormone metabolic process [GO:0042403]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}. Endosome membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}.
P55075	reviewed	FGF8_HUMAN	Fibroblast growth factor 8 (FGF-8) (Androgen-induced growth factor) (AIGF) (Heparin-binding growth factor 8) (HBGF-8)	FGF8 AIGF	Homo sapiens (Human)	233	FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111). {ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:8663044}.		anatomical structure morphogenesis [GO:0009653]; aorta morphogenesis [GO:0035909]; blood vessel remodeling [GO:0001974]; bone development [GO:0060348]; branching involved in blood vessel morphogenesis [GO:0001569]; branching involved in salivary gland morphogenesis [GO:0060445]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell fate commitment [GO:0045165]; cell migration involved in mesendoderm migration [GO:0090134]; cell proliferation in forebrain [GO:0021846]; corticotropin hormone secreting cell differentiation [GO:0060128]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axon guidance [GO:0033563]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube development [GO:0035050]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic neurocranium morphogenesis [GO:0048702]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; fibroblast growth factor receptor signaling pathway [GO:0008543]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain morphogenesis [GO:0048853]; forebrain neuron development [GO:0021884]; gastrulation [GO:0007369]; gonad development [GO:0008406]; heart looping [GO:0001947]; heart morphogenesis [GO:0003007]; larynx morphogenesis [GO:0120223]; limb morphogenesis [GO:0035108]; lung morphogenesis [GO:0060425]; male genitalia development [GO:0030539]; MAPK cascade [GO:0000165]; mesodermal cell migration [GO:0008078]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; midbrain-hindbrain boundary development [GO:0030917]; mitotic nuclear division [GO:0140014]; motor neuron axon guidance [GO:0008045]; negative regulation of cardiac muscle tissue development [GO:0055026]; negative regulation of neuron apoptotic process [GO:0043524]; neural plate morphogenesis [GO:0001839]; neuroepithelial cell differentiation [GO:0060563]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; odontogenesis [GO:0042476]; organ growth [GO:0035265]; organ induction [GO:0001759]; otic vesicle formation [GO:0030916]; outflow tract septum morphogenesis [GO:0003148]; pallium development [GO:0021543]; pharyngeal system development [GO:0060037]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of organ growth [GO:0046622]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stem cell proliferation [GO:2000648]; regulation of cell migration [GO:0030334]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]; signal transduction involved in regulation of gene expression [GO:0023019]; stem cell proliferation [GO:0072089]; subpallium development [GO:0021544]; thyroid gland development [GO:0030878]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; type 1 fibroblast growth factor receptor binding [GO:0005105]; type 2 fibroblast growth factor receptor binding [GO:0005111]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; type 1 fibroblast growth factor receptor binding [GO:0005105]; type 2 fibroblast growth factor receptor binding [GO:0005111]; anatomical structure morphogenesis [GO:0009653]; aorta morphogenesis [GO:0035909]; blood vessel remodeling [GO:0001974]; bone development [GO:0060348]; branching involved in blood vessel morphogenesis [GO:0001569]; branching involved in salivary gland morphogenesis [GO:0060445]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell fate commitment [GO:0045165]; cell migration involved in mesendoderm migration [GO:0090134]; cell proliferation in forebrain [GO:0021846]; corticotropin hormone secreting cell differentiation [GO:0060128]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axon guidance [GO:0033563]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube development [GO:0035050]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic neurocranium morphogenesis [GO:0048702]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; fibroblast growth factor receptor signaling pathway [GO:0008543]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain morphogenesis [GO:0048853]; forebrain neuron development [GO:0021884]; gastrulation [GO:0007369]; gonad development [GO:0008406]; heart looping [GO:0001947]; heart morphogenesis [GO:0003007]; larynx morphogenesis [GO:0120223]; limb morphogenesis [GO:0035108]; lung morphogenesis [GO:0060425]; male genitalia development [GO:0030539]; MAPK cascade [GO:0000165]; mesodermal cell migration [GO:0008078]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; midbrain-hindbrain boundary development [GO:0030917]; mitotic nuclear division [GO:0140014]; motor neuron axon guidance [GO:0008045]; negative regulation of cardiac muscle tissue development [GO:0055026]; negative regulation of neuron apoptotic process [GO:0043524]; neural plate morphogenesis [GO:0001839]; neuroepithelial cell differentiation [GO:0060563]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; odontogenesis [GO:0042476]; organ growth [GO:0035265]; organ induction [GO:0001759]; otic vesicle formation [GO:0030916]; outflow tract septum morphogenesis [GO:0003148]; pallium development [GO:0021543]; pharyngeal system development [GO:0060037]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of organ growth [GO:0046622]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stem cell proliferation [GO:2000648]; regulation of cell migration [GO:0030334]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]; signal transduction involved in regulation of gene expression [GO:0023019]; stem cell proliferation [GO:0072089]; subpallium development [GO:0021544]; thyroid gland development [GO:0030878]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]	SUBCELLULAR LOCATION: Secreted.
P55081	reviewed	MFAP1_HUMAN	Microfibrillar-associated protein 1 (Spliceosome B complex protein MFAP1)	MFAP1	Homo sapiens (Human)	439	FUNCTION: Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:28781166}.		mRNA splicing, via spliceosome [GO:0000398]	centrosome [GO:0005813]; microfibril [GO:0001527]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	RNA binding [GO:0003723]	centrosome [GO:0005813]; microfibril [GO:0001527]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28781166}.
P55082	reviewed	MFAP3_HUMAN	Microfibril-associated glycoprotein 3	MFAP3	Homo sapiens (Human)	362	FUNCTION: Component of the elastin-associated microfibrils.		interleukin-15-mediated signaling pathway [GO:0035723]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; T cell activation [GO:0042110]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; membrane raft [GO:0045121]	MHC class II protein binding [GO:0042289]; protein tyrosine kinase binding [GO:1990782]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; MHC class II protein binding [GO:0042289]; protein tyrosine kinase binding [GO:1990782]; interleukin-15-mediated signaling pathway [GO:0035723]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
P55083	reviewed	MFAP4_HUMAN	Microfibril-associated glycoprotein 4	MFAP4	Homo sapiens (Human)	255	FUNCTION: Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed:26601954). {ECO:0000269|PubMed:26601954}.		cell adhesion [GO:0007155]; cellular response to UV-B [GO:0071493]; elastic fiber assembly [GO:0048251]; regulation of collagen metabolic process [GO:0010712]; supramolecular fiber organization [GO:0097435]; UV protection [GO:0009650]	collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527]		collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527]; cell adhesion [GO:0007155]; cellular response to UV-B [GO:0071493]; elastic fiber assembly [GO:0048251]; regulation of collagen metabolic process [GO:0010712]; supramolecular fiber organization [GO:0097435]; UV protection [GO:0009650]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:26601954}.
P55084	reviewed	ECHB_HUMAN	Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)]	HADHB MSTP029	Homo sapiens (Human)	474	FUNCTION: Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:8135828, PubMed:29915090, PubMed:30850536). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity (PubMed:8135828, PubMed:29915090, PubMed:30850536). {ECO:0000269|PubMed:29915090, ECO:0000269|PubMed:30850536, ECO:0000269|PubMed:8135828, ECO:0000303|PubMed:29915090, ECO:0000303|PubMed:30850536}.		cellular response to lipopolysaccharide [GO:0071222]; fatty acid beta-oxidation [GO:0006635]; gene expression [GO:0010467]	endoplasmic reticulum [GO:0005783]; mitochondrial envelope [GO:0005740]; mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; enoyl-CoA hydratase activity [GO:0004300]; lncRNA binding [GO:0106222]; RNA binding [GO:0003723]	endoplasmic reticulum [GO:0005783]; mitochondrial envelope [GO:0005740]; mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; enoyl-CoA hydratase activity [GO:0004300]; lncRNA binding [GO:0106222]; RNA binding [GO:0003723]; cellular response to lipopolysaccharide [GO:0071222]; fatty acid beta-oxidation [GO:0006635]; gene expression [GO:0010467]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21527675}. Mitochondrion inner membrane {ECO:0000269|PubMed:21527675}. Mitochondrion outer membrane {ECO:0000269|PubMed:21527675}. Endoplasmic reticulum {ECO:0000269|PubMed:21527675}. Note=Protein stability and association with membranes require HADHA. {ECO:0000269|PubMed:29915090}.
P55085	reviewed	PAR2_HUMAN	Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]	F2RL1 GPR11 PAR2	Homo sapiens (Human)	397	FUNCTION: Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o)-alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as pro-inflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. {ECO:0000269|PubMed:10086357, ECO:0000269|PubMed:10725339, ECO:0000269|PubMed:11413129, ECO:0000269|PubMed:11441110, ECO:0000269|PubMed:11447194, ECO:0000269|PubMed:11714832, ECO:0000269|PubMed:12832443, ECO:0000269|PubMed:15155775, ECO:0000269|PubMed:16359518, ECO:0000269|PubMed:16410250, ECO:0000269|PubMed:16478888, ECO:0000269|PubMed:16714334, ECO:0000269|PubMed:17404307, ECO:0000269|PubMed:17500066, ECO:0000269|PubMed:18424071, ECO:0000269|PubMed:18453611, ECO:0000269|PubMed:18474671, ECO:0000269|PubMed:18622013, ECO:0000269|PubMed:19494303, ECO:0000269|PubMed:19781631, ECO:0000269|PubMed:19864598, ECO:0000269|PubMed:19865078, ECO:0000269|PubMed:20826780, ECO:0000269|PubMed:21501162, ECO:0000269|PubMed:23202369, ECO:0000269|PubMed:28445455}.	MISCELLANEOUS: Synthetic PAR agonist peptides (APs) that mimic the first six amino acids of the newly formed N-terminus activate the native, uncleaved receptor nonenzymatically by binding directly to the corresponding second extracellular loop to mediate signaling.	blood coagulation [GO:0007596]; cell-cell junction maintenance [GO:0045217]; defense response to virus [GO:0051607]; establishment of endothelial barrier [GO:0061028]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; leukocyte migration [GO:0050900]; leukocyte proliferation [GO:0070661]; mature conventional dendritic cell differentiation [GO:0097029]; negative regulation of chemokine production [GO:0032682]; negative regulation of insulin secretion [GO:0046676]; negative regulation of JNK cascade [GO:0046329]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; neutrophil activation [GO:0042119]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of chemokine production [GO:0032722]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of eosinophil degranulation [GO:0043311]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of neutrophil mediated killing of gram-negative bacterium [GO:0070963]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of renin secretion into blood stream [GO:1900135]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; potassium channel activating, G protein-coupled receptor signaling pathway [GO:0099109]; regulation of blood coagulation [GO:0030193]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of JNK cascade [GO:0046328]; T cell activation involved in immune response [GO:0002286]; vasodilation [GO:0042311]	early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]	G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; thrombin-activated receptor activity [GO:0015057]	early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; thrombin-activated receptor activity [GO:0015057]; blood coagulation [GO:0007596]; cell-cell junction maintenance [GO:0045217]; defense response to virus [GO:0051607]; establishment of endothelial barrier [GO:0061028]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; leukocyte migration [GO:0050900]; leukocyte proliferation [GO:0070661]; mature conventional dendritic cell differentiation [GO:0097029]; negative regulation of chemokine production [GO:0032682]; negative regulation of insulin secretion [GO:0046676]; negative regulation of JNK cascade [GO:0046329]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; neutrophil activation [GO:0042119]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of chemokine production [GO:0032722]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of eosinophil degranulation [GO:0043311]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of neutrophil mediated killing of gram-negative bacterium [GO:0070963]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of renin secretion into blood stream [GO:1900135]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; potassium channel activating, G protein-coupled receptor signaling pathway [GO:0099109]; regulation of blood coagulation [GO:0030193]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of JNK cascade [GO:0046328]; T cell activation involved in immune response [GO:0002286]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P55087	reviewed	AQP4_HUMAN	Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)	AQP4	Homo sapiens (Human)	323	FUNCTION: Forms a water-specific channel (PubMed:7559426, PubMed:8601457, PubMed:19383790). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). {ECO:0000250|UniProtKB:P55088, ECO:0000269|PubMed:19383790, ECO:0000269|PubMed:7559426, ECO:0000269|PubMed:8601457}.		cellular response to type II interferon [GO:0071346]; cerebrospinal fluid circulation [GO:0090660]; intracellular water homeostasis [GO:0009992]; multicellular organismal-level water homeostasis [GO:0050891]; protein homotetramerization [GO:0051289]; renal water homeostasis [GO:0003091]; water transport [GO:0006833]	astrocyte end-foot [GO:0097450]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	identical protein binding [GO:0042802]; water channel activity [GO:0015250]	astrocyte end-foot [GO:0097450]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; identical protein binding [GO:0042802]; water channel activity [GO:0015250]; cellular response to type II interferon [GO:0071346]; cerebrospinal fluid circulation [GO:0090660]; intracellular water homeostasis [GO:0009992]; multicellular organismal-level water homeostasis [GO:0050891]; protein homotetramerization [GO:0051289]; renal water homeostasis [GO:0003091]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7559426, ECO:0000269|PubMed:8601457}; Multi-pass membrane protein {ECO:0000269|PubMed:19383790}. Basolateral cell membrane {ECO:0000250|UniProtKB:P55088}; Multi-pass membrane protein {ECO:0000269|PubMed:19383790}. Endosome membrane {ECO:0000250|UniProtKB:P47863}. Cell membrane, sarcolemma {ECO:0000269|PubMed:29055082}; Multi-pass membrane protein {ECO:0000269|PubMed:19383790}. Cell projection {ECO:0000250|UniProtKB:P47863}. Note=Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries. {ECO:0000250|UniProtKB:P47863}.
P55089	reviewed	UCN1_HUMAN	Urocortin	UCN	Homo sapiens (Human)	124	FUNCTION: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity). {ECO:0000250|UniProtKB:P55090, ECO:0000250|UniProtKB:P81615, ECO:0000269|PubMed:8612563}.	MISCELLANEOUS: Positive correlation between increased expression in colonic lamina propria and severity of inflammation in patients with ulcerative colitis. {ECO:0000269|PubMed:15531481}.	aerobic respiration [GO:0009060]; associative learning [GO:0008306]; drinking behavior [GO:0042756]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of appetite [GO:0032099]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell size [GO:0045792]; negative regulation of feeding behavior [GO:2000252]; negative regulation of gene expression [GO:0010629]; negative regulation of hormone secretion [GO:0046888]; negative regulation of neuron apoptotic process [GO:0043524]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of cell growth [GO:0030307]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of corticotropin secretion [GO:0051461]; positive regulation of DNA replication [GO:0045740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of vascular permeability [GO:0043117]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to auditory stimulus [GO:0010996]; response to estradiol [GO:0032355]; response to glucocorticoid [GO:0051384]; response to oxidative stress [GO:0006979]; response to pain [GO:0048265]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; startle response [GO:0001964]; vasodilation [GO:0042311]	axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular region [GO:0005576]; perikaryon [GO:0043204]; varicosity [GO:0043196]	corticotropin-releasing hormone receptor 1 binding [GO:0051430]; corticotropin-releasing hormone receptor 2 binding [GO:0051431]; histone deacetylase inhibitor activity [GO:0046811]; neuropeptide hormone activity [GO:0005184]	axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular region [GO:0005576]; perikaryon [GO:0043204]; varicosity [GO:0043196]; corticotropin-releasing hormone receptor 1 binding [GO:0051430]; corticotropin-releasing hormone receptor 2 binding [GO:0051431]; histone deacetylase inhibitor activity [GO:0046811]; neuropeptide hormone activity [GO:0005184]; aerobic respiration [GO:0009060]; associative learning [GO:0008306]; drinking behavior [GO:0042756]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of appetite [GO:0032099]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell size [GO:0045792]; negative regulation of feeding behavior [GO:2000252]; negative regulation of gene expression [GO:0010629]; negative regulation of hormone secretion [GO:0046888]; negative regulation of neuron apoptotic process [GO:0043524]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of cell growth [GO:0030307]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of corticotropin secretion [GO:0051461]; positive regulation of DNA replication [GO:0045740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of vascular permeability [GO:0043117]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to auditory stimulus [GO:0010996]; response to estradiol [GO:0032355]; response to glucocorticoid [GO:0051384]; response to oxidative stress [GO:0006979]; response to pain [GO:0048265]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; startle response [GO:0001964]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Secreted.
P55107	reviewed	GDF10_HUMAN	Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)	GDF10 BMP3B	Homo sapiens (Human)	478	FUNCTION: Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. {ECO:0000250|UniProtKB:P97737}.		cerebellum development [GO:0021549]; fat cell differentiation [GO:0045444]; osteoblast differentiation [GO:0001649]; ovulation cycle [GO:0042698]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of ossification [GO:0030278]; response to kainic acid [GO:1904373]; skeletal system development [GO:0001501]; transforming growth factor beta receptor signaling pathway [GO:0007179]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; cerebellum development [GO:0021549]; fat cell differentiation [GO:0045444]; osteoblast differentiation [GO:0001649]; ovulation cycle [GO:0042698]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of ossification [GO:0030278]; response to kainic acid [GO:1904373]; skeletal system development [GO:0001501]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P97737}.
P55145	reviewed	MANF_HUMAN	Mesencephalic astrocyte-derived neurotrophic factor (Arginine-rich protein) (Protein ARMET)	MANF ARMET ARP	Homo sapiens (Human)	182	FUNCTION: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (PubMed:12794311). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (By similarity). Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (PubMed:18561914, PubMed:22637475, PubMed:29497057). Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475). Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (PubMed:29497057). Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions (PubMed:29497057). {ECO:0000250|UniProtKB:P0C5H9, ECO:0000269|PubMed:12794311, ECO:0000269|PubMed:18561914, ECO:0000269|PubMed:22637475, ECO:0000269|PubMed:29497057}.		dopaminergic neuron differentiation [GO:0071542]; neuron projection development [GO:0031175]; regulation of response to endoplasmic reticulum stress [GO:1905897]; response to unfolded protein [GO:0006986]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; sarcoplasmic reticulum lumen [GO:0033018]	growth factor activity [GO:0008083]; RNA binding [GO:0003723]; sulfatide binding [GO:0120146]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; sarcoplasmic reticulum lumen [GO:0033018]; growth factor activity [GO:0008083]; RNA binding [GO:0003723]; sulfatide binding [GO:0120146]; dopaminergic neuron differentiation [GO:0071542]; neuron projection development [GO:0031175]; regulation of response to endoplasmic reticulum stress [GO:1905897]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12794311, ECO:0000269|PubMed:18561914, ECO:0000269|PubMed:22637475, ECO:0000269|PubMed:29497057}. Endoplasmic reticulum lumen {ECO:0000305|PubMed:29497057}. Sarcoplasmic reticulum lumen {ECO:0000269|PubMed:22637475}. Note=Retained in the endoplasmic reticulum (ER), and sarcoplasmic reticulum (SR) under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475, PubMed:29497057). {ECO:0000269|PubMed:22637475, ECO:0000269|PubMed:29497057}.
P55157	reviewed	MTP_HUMAN	Microsomal triglyceride transfer protein large subunit	MTTP MTP	Homo sapiens (Human)	894	FUNCTION: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406, PubMed:16478722, PubMed:15897609, PubMed:8876250). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:8876250, PubMed:16478722). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity). {ECO:0000250|UniProtKB:O08601, ECO:0000269|PubMed:15897609, ECO:0000269|PubMed:16478722, ECO:0000269|PubMed:22236406, ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:25108285, ECO:0000269|PubMed:26224785, ECO:0000269|PubMed:8876250, ECO:0000269|PubMed:8939939}.		cholesterol homeostasis [GO:0042632]; chylomicron assembly [GO:0034378]; circadian rhythm [GO:0007623]; establishment of localization in cell [GO:0051649]; lipid metabolic process [GO:0006629]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; low-density lipoprotein particle remodeling [GO:0034374]; phospholipid transport [GO:0015914]; plasma lipoprotein particle assembly [GO:0034377]; protein secretion [GO:0009306]; response to calcium ion [GO:0051592]; triglyceride metabolic process [GO:0006641]; triglyceride transport [GO:0034197]; very-low-density lipoprotein particle assembly [GO:0034379]	basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; microvillus membrane [GO:0031528]; receptor complex [GO:0043235]; vesicle [GO:0031982]	apolipoprotein binding [GO:0034185]; ceramide 1-phosphate transfer activity [GO:1902388]; cholesterol transfer activity [GO:0120020]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylethanolamine transfer activity [GO:1904121]; phospholipid transfer activity [GO:0120014]; phospholipid transporter activity [GO:0005548]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]; triglyceride transfer activity [GO:0140344]	basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; microvillus membrane [GO:0031528]; receptor complex [GO:0043235]; vesicle [GO:0031982]; apolipoprotein binding [GO:0034185]; ceramide 1-phosphate transfer activity [GO:1902388]; cholesterol transfer activity [GO:0120020]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylethanolamine transfer activity [GO:1904121]; phospholipid transfer activity [GO:0120014]; phospholipid transporter activity [GO:0005548]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]; triglyceride transfer activity [GO:0140344]; cholesterol homeostasis [GO:0042632]; chylomicron assembly [GO:0034378]; circadian rhythm [GO:0007623]; establishment of localization in cell [GO:0051649]; lipid metabolic process [GO:0006629]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; low-density lipoprotein particle remodeling [GO:0034374]; phospholipid transport [GO:0015914]; plasma lipoprotein particle assembly [GO:0034377]; protein secretion [GO:0009306]; response to calcium ion [GO:0051592]; triglyceride metabolic process [GO:0006641]; triglyceride transport [GO:0034197]; very-low-density lipoprotein particle assembly [GO:0034379]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:16478722, ECO:0000269|PubMed:22236406, ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:26224785}. Golgi apparatus {ECO:0000269|PubMed:16478722}. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785). {ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:26224785}.
P55160	reviewed	NCKPL_HUMAN	Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1)	NCKAP1L HEM1	Homo sapiens (Human)	1127	FUNCTION: Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells (PubMed:32647003). Required for efficient T-lymphocyte and neutrophil migration (PubMed:32647003). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (PubMed:32647003). {ECO:0000250|UniProtKB:Q8K1X4, ECO:0000269|PubMed:16417406, ECO:0000269|PubMed:17696648, ECO:0000269|PubMed:32647003, ECO:0000303|PubMed:20969869}.		actin polymerization-dependent cell motility [GO:0070358]; B cell homeostasis [GO:0001782]; B cell receptor signaling pathway [GO:0050853]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; chemotaxis [GO:0006935]; cortical actin cytoskeleton organization [GO:0030866]; erythrocyte development [GO:0048821]; erythrocyte homeostasis [GO:0034101]; maintenance of cell polarity [GO:0030011]; myeloid cell homeostasis [GO:0002262]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; neuron projection morphogenesis [GO:0048812]; neutrophil chemotaxis [GO:0030593]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of phosphorylation [GO:0042327]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of TORC2 signaling [GO:1904515]; protein-containing complex assembly [GO:0065003]; response to xenobiotic stimulus [GO:0009410]; T cell homeostasis [GO:0043029]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; SCAR complex [GO:0031209]; secretory granule membrane [GO:0030667]	GTPase activator activity [GO:0005096]; protein kinase activator activity [GO:0030295]; protein-containing complex binding [GO:0044877]; TORC2 complex binding [GO:1904841]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; SCAR complex [GO:0031209]; secretory granule membrane [GO:0030667]; GTPase activator activity [GO:0005096]; protein kinase activator activity [GO:0030295]; protein-containing complex binding [GO:0044877]; TORC2 complex binding [GO:1904841]; actin polymerization-dependent cell motility [GO:0070358]; B cell homeostasis [GO:0001782]; B cell receptor signaling pathway [GO:0050853]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; chemotaxis [GO:0006935]; cortical actin cytoskeleton organization [GO:0030866]; erythrocyte development [GO:0048821]; erythrocyte homeostasis [GO:0034101]; maintenance of cell polarity [GO:0030011]; myeloid cell homeostasis [GO:0002262]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; neuron projection morphogenesis [GO:0048812]; neutrophil chemotaxis [GO:0030593]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of phosphorylation [GO:0042327]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of TORC2 signaling [GO:1904515]; protein-containing complex assembly [GO:0065003]; response to xenobiotic stimulus [GO:0009410]; T cell homeostasis [GO:0043029]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16417406}; Single-pass membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16417406}. Note=Localizes to the leading edge of polarized neutrophils. {ECO:0000269|PubMed:16417406, ECO:0000269|PubMed:17696648}.
P55196	reviewed	AFAD_HUMAN	Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)	AFDN AF6 MLLT4	Homo sapiens (Human)	1824	FUNCTION: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}.	MISCELLANEOUS: [Isoform 1]: May be due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.	bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell signaling [GO:0007267]; establishment of endothelial intestinal barrier [GO:0090557]; establishment of protein localization to plasma membrane [GO:0061951]; negative regulation of cell migration [GO:0030336]; pore complex assembly [GO:0046931]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of gene expression [GO:0010628]; regulation of protein localization [GO:0032880]; signal transduction [GO:0007165]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; tight junction [GO:0070160]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; small GTPase binding [GO:0031267]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; tight junction [GO:0070160]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; small GTPase binding [GO:0031267]; bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell signaling [GO:0007267]; establishment of endothelial intestinal barrier [GO:0090557]; establishment of protein localization to plasma membrane [GO:0061951]; negative regulation of cell migration [GO:0030336]; pore complex assembly [GO:0046931]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of gene expression [GO:0010628]; regulation of protein localization [GO:0032880]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Note=Not found at cell-matrix AJs. {ECO:0000250|UniProtKB:O35889}.
P55197	reviewed	AF10_HUMAN	Protein AF-10 (ALL1-fused gene from chromosome 10 protein)	MLLT10 AF10	Homo sapiens (Human)	1068	FUNCTION: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10860745}.
P55198	reviewed	AF17_HUMAN	Protein AF-17 (ALL1-fused gene from chromosome 17 protein)	MLLT6 AF17	Homo sapiens (Human)	1093			chromatin organization [GO:0006325]; negative regulation of urine volume [GO:0035811]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; renal potassium excretion [GO:0036359]; renal sodium excretion [GO:0035812]; renal water absorption [GO:0070295]	nucleus [GO:0005634]	histone binding [GO:0042393]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]	nucleus [GO:0005634]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; chromatin organization [GO:0006325]; negative regulation of urine volume [GO:0035811]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; renal potassium excretion [GO:0036359]; renal sodium excretion [GO:0035812]; renal water absorption [GO:0070295]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P55199	reviewed	ELL_HUMAN	RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein)	ELL C19orf17	Homo sapiens (Human)	621	FUNCTION: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}.		in utero embryonic development [GO:0001701]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; transcription elongation by RNA polymerase II [GO:0006368]	Cajal body [GO:0015030]; cytosol [GO:0005829]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; phosphatase binding [GO:0019902]	Cajal body [GO:0015030]; cytosol [GO:0005829]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; phosphatase binding [GO:0019902]; in utero embryonic development [GO:0001701]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11418481, ECO:0000269|PubMed:12446457}. Nucleus speckle {ECO:0000269|PubMed:11418481, ECO:0000269|PubMed:12446457}. Nucleus, Cajal body {ECO:0000269|PubMed:12686606, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. Note=Colocalizes with EAF2 to nuclear speckles (PubMed:12446457). Colocalizes with coilin in subnuclear cajal and histone locus bodies (PubMed:12686606). Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes(PubMed:23932780). {ECO:0000269|PubMed:12446457, ECO:0000269|PubMed:12686606, ECO:0000269|PubMed:23932780}.
P55201	reviewed	BRPF1_HUMAN	Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140)	BRPF1 BR140	Homo sapiens (Human)	1214	FUNCTION: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}.		chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	acetyltransferase activator activity [GO:0010698]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; acetyltransferase activator activity [GO:0010698]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:27939640}. Chromosome {ECO:0000269|PubMed:24065767}. Cytoplasm {ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:27939640}. Note=Localization to the nucleus depends on KAT6A, ING5 and MEAF6 (PubMed:18794358, PubMed:27939640). Localizes to transcription start sites (PubMed:24065767). {ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}.
P55209	reviewed	NP1L1_HUMAN	Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP)	NAP1L1 NRP	Homo sapiens (Human)	391	FUNCTION: Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly (PubMed:20002496, PubMed:21211722, PubMed:26841755). Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair (PubMed:28369616). Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (PubMed:24798879). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). {ECO:0000250|UniProtKB:P28656, ECO:0000269|PubMed:20002496, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:24798879, ECO:0000269|PubMed:26841755, ECO:0000269|PubMed:28369616}.; FUNCTION: (Microbial infection) Positively regulates Epstein-Barr virus reactivation in epithelial cells through the induction of viral BZLF1 expression. {ECO:0000269|PubMed:23691099}.; FUNCTION: (Microbial infection) Together with human herpesvirus 8 protein LANA1, assists the proper assembly of the nucleosome on the replicated viral DNA. {ECO:0000269|PubMed:27599637}.		DNA replication [GO:0006260]; nervous system development [GO:0007399]; nucleosome assembly [GO:0006334]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; RNA binding [GO:0003723]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; RNA binding [GO:0003723]; DNA replication [GO:0006260]; nervous system development [GO:0007399]; nucleosome assembly [GO:0006334]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:20002496, ECO:0000269|PubMed:27599637}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm {ECO:0000269|PubMed:20002496, ECO:0000269|PubMed:28659470}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
P55210	reviewed	CASP7_HUMAN	Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]	CASP7 MCH3	Homo sapiens (Human)	303	FUNCTION: Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:8521391, PubMed:8567622, PubMed:8576161, PubMed:9070923, PubMed:16916640, PubMed:17646170, PubMed:18723680, PubMed:19581639, PubMed:11257230, PubMed:11257231, PubMed:11701129, PubMed:15314233). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (PubMed:12824163, PubMed:19581639, PubMed:20566630, PubMed:15314233, PubMed:17697120, PubMed:23897474, PubMed:23650375, PubMed:27032039). Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1 (PubMed:10497198, PubMed:16123041, PubMed:16374543, PubMed:16916640, PubMed:18723680, PubMed:20566630, PubMed:21555521, PubMed:22184066, PubMed:22451931, PubMed:28863261, PubMed:31586028, PubMed:34156061, PubMed:27889207, PubMed:35338844, PubMed:35446120). Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (PubMed:18723680). Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (PubMed:21157428). Regulates pyroptosis in intestinal epithelial cells: cleaved and activated by CASP1 in response to S.typhimurium infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of gasdermin-D (GSDMD) pores (By similarity). Regulates granzyme-mediated programmed cell death in hepatocytes: cleaved and activated by granzyme B (GZMB) in response to bacterial infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of perforin (PRF1) pores (By similarity). Following cleavage by CASP1 in response to inflammasome activation, catalyzes processing and inactivation of PARP1, alleviating the transcription repressor activity of PARP1 (PubMed:22464733). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (By similarity). Cleaves and activates sterol regulatory element binding proteins (SREBPs) (PubMed:8643593). Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (By similarity). In case of infection, catalyzes cleavage of Kaposi sarcoma-associated herpesvirus protein ORF57, thereby preventing expression of viral lytic genes (PubMed:20159985). {ECO:0000250|UniProtKB:P97864, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:11257230, ECO:0000269|PubMed:11257231, ECO:0000269|PubMed:11701129, ECO:0000269|PubMed:12824163, ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:17646170, ECO:0000269|PubMed:17697120, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:19581639, ECO:0000269|PubMed:20159985, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21157428, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22451931, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23897474, ECO:0000269|PubMed:27032039, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:28863261, ECO:0000269|PubMed:31586028, ECO:0000269|PubMed:34156061, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:8521391, ECO:0000269|PubMed:8567622, ECO:0000269|PubMed:8576161, ECO:0000269|PubMed:8643593, ECO:0000269|PubMed:9070923}.; FUNCTION: [Isoform Beta]: Lacks enzymatic activity. {ECO:0000269|PubMed:8521391}.		apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to staurosporine [GO:0072734]; defense response to bacterium [GO:0042742]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; heart development [GO:0007507]; lymphocyte apoptotic process [GO:0070227]; neuron apoptotic process [GO:0051402]; positive regulation of plasma membrane repair [GO:1905686]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411]; striated muscle cell differentiation [GO:0051146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	aspartic-type endopeptidase activity [GO:0004190]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; cysteine-type peptidase activity [GO:0008234]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; aspartic-type endopeptidase activity [GO:0004190]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; cysteine-type peptidase activity [GO:0008234]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to staurosporine [GO:0072734]; defense response to bacterium [GO:0042742]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; heart development [GO:0007507]; lymphocyte apoptotic process [GO:0070227]; neuron apoptotic process [GO:0051402]; positive regulation of plasma membrane repair [GO:1905686]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411]; striated muscle cell differentiation [GO:0051146]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12824163, ECO:0000305|PubMed:21555521, ECO:0000305|PubMed:8576161}. Nucleus {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21555521}. Secreted, extracellular space {ECO:0000250|UniProtKB:P97864}. Note=Following cleavage and activation by CASP1 or granzyme B (GZMB), secreted into the extracellular milieu by passing through the gasdermin-D (GSDMD) pores or perforin (PRF1) pore, respectively. {ECO:0000250|UniProtKB:P97864}.
P55211	reviewed	CASP9_HUMAN	Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]	CASP9 MCH6	Homo sapiens (Human)	416	FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). {ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120}.; FUNCTION: [Isoform 2]: Lacks activity is an dominant-negative inhibitor of caspase-9. {ECO:0000269|PubMed:10070954}.	MISCELLANEOUS: [Isoform 3]: May function as an endogenous apoptotic inhibitor, inhibits the BAX-mediated cleavage of procaspase-3. {ECO:0000305}.	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; epithelial cell apoptotic process [GO:1904019]; fibroblast apoptotic process [GO:0044346]; glial cell apoptotic process [GO:0034349]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; kidney development [GO:0001822]; leukocyte apoptotic process [GO:0071887]; neuron apoptotic process [GO:0051402]; platelet formation [GO:0030220]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron apoptotic process [GO:0043525]; protein maturation [GO:0051604]; protein processing [GO:0016485]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; signal transduction in response to DNA damage [GO:0042770]	apoptosome [GO:0043293]; caspase complex [GO:0008303]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]	apoptosome [GO:0043293]; caspase complex [GO:0008303]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; epithelial cell apoptotic process [GO:1904019]; fibroblast apoptotic process [GO:0044346]; glial cell apoptotic process [GO:0034349]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; kidney development [GO:0001822]; leukocyte apoptotic process [GO:0071887]; neuron apoptotic process [GO:0051402]; platelet formation [GO:0030220]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron apoptotic process [GO:0043525]; protein maturation [GO:0051604]; protein processing [GO:0016485]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; signal transduction in response to DNA damage [GO:0042770]	
P55212	reviewed	CASP6_HUMAN	Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)]	CASP6 MCH2	Homo sapiens (Human)	293	FUNCTION: Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (PubMed:8663580, PubMed:19133298, PubMed:22858542, PubMed:27032039, PubMed:28864531, PubMed:30420425, PubMed:32298652). Acts as a non-canonical executioner caspase during apoptosis: localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed:8663580, PubMed:9463409, PubMed:11953316, PubMed:17401638). Lamin-A/LMNA cleavage is required for chromatin condensation and nuclear disassembly during apoptotic execution (PubMed:11953316). Acts as a regulator of liver damage by promoting hepatocyte apoptosis: in absence of phosphorylation by AMP-activated protein kinase (AMPK), catalyzes cleavage of BID, leading to cytochrome c release, thereby participating in nonalcoholic steatohepatitis (PubMed:32029622). Cleaves PARK7/DJ-1 in cells undergoing apoptosis (By similarity). Involved in intrinsic apoptosis by mediating cleavage of RIPK1 (PubMed:22858542). Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (PubMed:10559921, PubMed:14657026). Cleaves phospholipid scramblase proteins XKR4 and XKR9 (By similarity). In addition to apoptosis, involved in different forms of programmed cell death (PubMed:32298652). Plays an essential role in defense against viruses by acting as a central mediator of the ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis), independently of its cysteine protease activity (PubMed:32298652). PANoptosis is a unique inflammatory programmed cell death, which provides a molecular scaffold that allows the interactions and activation of machinery required for inflammasome/pyroptosis, apoptosis and necroptosis (PubMed:32298652). Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (PubMed:32298652). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis (By similarity). Regulates B-cell programs both during early development and after antigen stimulation (By similarity). {ECO:0000250|UniProtKB:O08738, ECO:0000269|PubMed:10559921, ECO:0000269|PubMed:11953316, ECO:0000269|PubMed:14657026, ECO:0000269|PubMed:17401638, ECO:0000269|PubMed:19133298, ECO:0000269|PubMed:22858542, ECO:0000269|PubMed:27032039, ECO:0000269|PubMed:28864531, ECO:0000269|PubMed:30420425, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:8663580, ECO:0000269|PubMed:9463409}.; FUNCTION: (Microbial infection) Proteolytically cleaves the N protein of coronoviruses such as MERS-CoV and SARS-CoV (PubMed:35922005, PubMed:18155731). The cleavage of MERS-CoV N-protein leads to two fragments and modulates coronavirus replication by regulating IFN signaling. The two fragments produced by the cleavage interact with IRF3 inhibiting its nuclear translocation after activation and reduce the expression of IFNB and IFN-stimulated genes (PubMed:35922005). The same mechanism seems to be used by other coronaviruses such as SARS-CoV and SARS-CoV-2 to enhance their replication (PubMed:35922005). {ECO:0000269|PubMed:18155731, ECO:0000269|PubMed:35922005}.		activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; cellular response to staurosporine [GO:0072734]; epithelial cell differentiation [GO:0030855]; hepatocyte apoptotic process [GO:0097284]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of apoptotic process [GO:0043065]; positive regulation of necroptotic process [GO:0060545]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; regulation of programmed cell death [GO:0043067]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; cysteine-type peptidase activity [GO:0008234]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; cysteine-type peptidase activity [GO:0008234]; identical protein binding [GO:0042802]; activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; cellular response to staurosporine [GO:0072734]; epithelial cell differentiation [GO:0030855]; hepatocyte apoptotic process [GO:0097284]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of apoptotic process [GO:0043065]; positive regulation of necroptotic process [GO:0060545]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; regulation of programmed cell death [GO:0043067]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27911442}. Nucleus {ECO:0000269|PubMed:27911442}.
P55259	reviewed	GP2_HUMAN	Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75)	GP2	Homo sapiens (Human)	537	FUNCTION: Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response. {ECO:0000269|PubMed:35273390, ECO:0000305|PubMed:19907495}.		antigen transcytosis by M cells in mucosal-associated lymphoid tissue [GO:0002412]; innate immune response [GO:0045087]; neutrophil migration [GO:1990266]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; zymogen granule membrane [GO:0042589]	antigen binding [GO:0003823]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; zymogen granule membrane [GO:0042589]; antigen binding [GO:0003823]; antigen transcytosis by M cells in mucosal-associated lymphoid tissue [GO:0002412]; innate immune response [GO:0045087]; neutrophil migration [GO:1990266]	SUBCELLULAR LOCATION: Zymogen granule membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Secreted {ECO:0000269|PubMed:10760606}. Cell membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D733}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Membrane raft {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Endosome {ECO:0000250|UniProtKB:Q9D733}. Note=Secreted, after cleavage, in the pancreatic juice. {ECO:0000305|PubMed:10760606}.
P55263	reviewed	ADK_HUMAN	Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase)	ADK	Homo sapiens (Human)	362	FUNCTION: Catalyzes the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. {ECO:0000269|PubMed:21963049, ECO:0000269|PubMed:8577746, ECO:0000269|PubMed:9070863}.		AMP salvage [GO:0044209]; dAMP salvage [GO:0106383]; dATP biosynthetic process [GO:0006175]; GMP salvage [GO:0032263]; phosphorylation [GO:0016310]; purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside salvage [GO:0006166]; ribonucleoside monophosphate biosynthetic process [GO:0009156]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	adenosine kinase activity [GO:0004001]; ATP binding [GO:0005524]; deoxyadenosine kinase activity [GO:0004136]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; adenosine kinase activity [GO:0004001]; ATP binding [GO:0005524]; deoxyadenosine kinase activity [GO:0004136]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; AMP salvage [GO:0044209]; dAMP salvage [GO:0106383]; dATP biosynthetic process [GO:0006175]; GMP salvage [GO:0032263]; phosphorylation [GO:0016310]; purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside salvage [GO:0006166]; ribonucleoside monophosphate biosynthetic process [GO:0009156]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:19635462}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19635462}.
P55265	reviewed	DSRAD_HUMAN	Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP)	ADAR ADAR1 DSRAD G1P1 IFI4	Homo sapiens (Human)	1226	FUNCTION: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:7972084, PubMed:7565688, PubMed:12618436). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative promoter usage. {ECO:0000305}.	adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; hepatocyte apoptotic process [GO:0097284]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of post-transcriptional gene silencing by regulatory ncRNA [GO:1900369]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; RISC complex assembly [GO:0070922]; RNA processing [GO:0006396]; somatic diversification of immune receptors via somatic mutation [GO:0002566]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; supraspliceosomal complex [GO:0044530]	DNA binding [GO:0003677]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; supraspliceosomal complex [GO:0044530]; DNA binding [GO:0003677]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251]; adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; hepatocyte apoptotic process [GO:0097284]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of post-transcriptional gene silencing by regulatory ncRNA [GO:1900369]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; RISC complex assembly [GO:0070922]; RNA processing [GO:0006396]; somatic diversification of immune receptors via somatic mutation [GO:0002566]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:7565688}. Nucleus {ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:7565688}. Note=Shuttles between the cytoplasm and nucleus (PubMed:7565688, PubMed:24753571). Nuclear import is mediated by TNPO1 (PubMed:24753571). {ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:7565688}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:19124606}. Nucleus {ECO:0000269|PubMed:19124606, ECO:0000269|PubMed:7565688}. Nucleus, nucleolus {ECO:0000269|PubMed:12665561}. Note=Predominantly nuclear but can shuttle between nucleus and cytoplasm. TNPO1 can mediate its nuclear import whereas XPO5 can mediate its nuclear export. {ECO:0000269|PubMed:19124606}.
P55268	reviewed	LAMB2_HUMAN	Laminin subunit beta-2 (Laminin B1s chain) (Laminin-11 subunit beta) (Laminin-14 subunit beta) (Laminin-15 subunit beta) (Laminin-3 subunit beta) (Laminin-4 subunit beta) (Laminin-7 subunit beta) (Laminin-9 subunit beta) (S-laminin subunit beta) (S-LAM beta)	LAMB2 LAMS	Homo sapiens (Human)	1798	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.		astrocyte development [GO:0014002]; axon extension involved in regeneration [GO:0048677]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; metanephric glomerular basement membrane development [GO:0072274]; metanephric podocyte development [GO:0072249]; neuromuscular junction development [GO:0007528]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; retina development in camera-type eye [GO:0060041]; Schwann cell development [GO:0014044]; visual perception [GO:0007601]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; laminin-11 complex [GO:0043260]; laminin-3 complex [GO:0005608]; neuromuscular junction [GO:0031594]; protein complex involved in cell-matrix adhesion [GO:0098637]; synaptic cleft [GO:0043083]	extracellular matrix structural constituent [GO:0005201]; integrin binding [GO:0005178]; structural constituent of synapse-associated extracellular matrix [GO:0150043]; structural molecule activity [GO:0005198]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; laminin-11 complex [GO:0043260]; laminin-3 complex [GO:0005608]; neuromuscular junction [GO:0031594]; protein complex involved in cell-matrix adhesion [GO:0098637]; synaptic cleft [GO:0043083]; extracellular matrix structural constituent [GO:0005201]; integrin binding [GO:0005178]; structural constituent of synapse-associated extracellular matrix [GO:0150043]; structural molecule activity [GO:0005198]; astrocyte development [GO:0014002]; axon extension involved in regeneration [GO:0048677]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; metanephric glomerular basement membrane development [GO:0072274]; metanephric podocyte development [GO:0072249]; neuromuscular junction development [GO:0007528]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; retina development in camera-type eye [GO:0060041]; Schwann cell development [GO:0014044]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=S-laminin is concentrated in the synaptic cleft of the neuromuscular junction.
P55273	reviewed	CDN2D_HUMAN	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d)	CDKN2D	Homo sapiens (Human)	166	FUNCTION: Interacts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269|PubMed:7739548, ECO:0000269|PubMed:8741839}.		autophagic cell death [GO:0048102]; cell cycle [GO:0007049]; DNA synthesis involved in DNA repair [GO:0000731]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of phosphorylation [GO:0042326]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; response to retinoic acid [GO:0032526]; response to UV [GO:0009411]; response to vitamin D [GO:0033280]; sensory perception of sound [GO:0007605]	cyclin D2-CDK4 complex [GO:0097129]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein kinase binding [GO:0019901]	cyclin D2-CDK4 complex [GO:0097129]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein kinase binding [GO:0019901]; autophagic cell death [GO:0048102]; cell cycle [GO:0007049]; DNA synthesis involved in DNA repair [GO:0000731]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of phosphorylation [GO:0042326]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; response to retinoic acid [GO:0032526]; response to UV [GO:0009411]; response to vitamin D [GO:0033280]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9482106}. Cytoplasm {ECO:0000269|PubMed:9482106}.
P55283	reviewed	CADH4_HUMAN	Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin)	CDH4	Homo sapiens (Human)	916	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.		adherens junction organization [GO:0034332]; axon extension [GO:0048675]; axon guidance [GO:0007411]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of axon extension [GO:0045773]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; axon extension [GO:0048675]; axon guidance [GO:0007411]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of axon extension [GO:0045773]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P55285	reviewed	CADH6_HUMAN	Cadherin-6 (Kidney cadherin) (K-cadherin)	CDH6	Homo sapiens (Human)	790	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; Notch signaling pathway [GO:0007219]; synaptic membrane adhesion [GO:0099560]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell junction [GO:0030054]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell junction [GO:0030054]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; Notch signaling pathway [GO:0007219]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P55286	reviewed	CADH8_HUMAN	Cadherin-8	CDH8	Homo sapiens (Human)	799	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of synapse organization [GO:0050807]; response to cold [GO:0009409]; synaptic transmission, glutamatergic [GO:0035249]	adherens junction [GO:0005912]; axon terminus [GO:0043679]; catenin complex [GO:0016342]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; synaptic membrane [GO:0097060]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]	adherens junction [GO:0005912]; axon terminus [GO:0043679]; catenin complex [GO:0016342]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; synaptic membrane [GO:0097060]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of synapse organization [GO:0050807]; response to cold [GO:0009409]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P55287	reviewed	CAD11_HUMAN	Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin)	CDH11	Homo sapiens (Human)	796	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation of cell migration (PubMed:33811546). {ECO:0000269|PubMed:33811546}.		adherens junction organization [GO:0034332]; aortic valve formation [GO:0003189]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; corticospinal tract morphogenesis [GO:0021957]; focal adhesion assembly [GO:0048041]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cell migration [GO:0030336]; ossification [GO:0001503]; skeletal system development [GO:0001501]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; aortic valve formation [GO:0003189]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; corticospinal tract morphogenesis [GO:0021957]; focal adhesion assembly [GO:0048041]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cell migration [GO:0030336]; ossification [GO:0001503]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P55289	reviewed	CAD12_HUMAN	Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2)	CDH12	Homo sapiens (Human)	794	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P55290	reviewed	CAD13_HUMAN	Cadherin-13 (Heart cadherin) (H-cadherin) (P105) (Truncated cadherin) (T-cad) (T-cadherin)	CDH13 CDHH	Homo sapiens (Human)	713	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. {ECO:0000269|PubMed:10737605}.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; endothelial cell migration [GO:0043542]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte proliferation [GO:0043616]; lamellipodium assembly [GO:0030032]; localization within membrane [GO:0051668]; low-density lipoprotein particle mediated signaling [GO:0055096]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Rac protein signal transduction [GO:0016601]; regulation of endocytosis [GO:0030100]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; Rho protein signal transduction [GO:0007266]; sprouting angiogenesis [GO:0002040]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; caveola [GO:0005901]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	adiponectin binding [GO:0055100]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle binding [GO:0030169]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; caveola [GO:0005901]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; adiponectin binding [GO:0055100]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle binding [GO:0030169]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; endothelial cell migration [GO:0043542]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte proliferation [GO:0043616]; lamellipodium assembly [GO:0030032]; localization within membrane [GO:0051668]; low-density lipoprotein particle mediated signaling [GO:0055096]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Rac protein signal transduction [GO:0016601]; regulation of endocytosis [GO:0030100]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; Rho protein signal transduction [GO:0007266]; sprouting angiogenesis [GO:0002040]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
P55291	reviewed	CAD15_HUMAN	Cadherin-15 (Cadherin-14) (Muscle cadherin) (M-cadherin)	CDH15 CDH14 CDH3	Homo sapiens (Human)	814	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; caveola [GO:0005901]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; caveola [GO:0005901]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P55316	reviewed	FOXG1_HUMAN	Forkhead box protein G1 (Brain factor 1) (BF-1) (BF1) (Brain factor 2) (BF-2) (BF2) (hBF-2) (Forkhead box protein G1A) (Forkhead box protein G1B) (Forkhead box protein G1C) (Forkhead-related protein FKHL1) (HFK1) (Forkhead-related protein FKHL2) (HFK2) (Forkhead-related protein FKHL3) (HFK3)	FOXG1 FKH2 FKHL1 FKHL2 FKHL3 FKHL4 FOXG1A FOXG1B FOXG1C	Homo sapiens (Human)	489	FUNCTION: Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. {ECO:0000269|PubMed:12657635}.		axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; dorsal/ventral pattern formation [GO:0009953]; inner ear morphogenesis [GO:0042472]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; positive regulation of cell cycle [GO:0045787]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron differentiation [GO:0045666]; pyramidal neuron migration to cerebral cortex [GO:0021852]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; dorsal/ventral pattern formation [GO:0009953]; inner ear morphogenesis [GO:0042472]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; positive regulation of cell cycle [GO:0045787]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron differentiation [GO:0045666]; pyramidal neuron migration to cerebral cortex [GO:0021852]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:21280142}.
P55317	reviewed	FOXA1_HUMAN	Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A)	FOXA1 HNF3A TCF3A	Homo sapiens (Human)	472	FUNCTION: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863, ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809, ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}.		alveolar secondary septum development [GO:0061144]; anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral neural tube patterning [GO:0021904]; epithelial cell maturation involved in prostate gland development [GO:0060743]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; epithelial-mesenchymal signaling involved in prostate gland development [GO:0060738]; glucose homeostasis [GO:0042593]; hormone metabolic process [GO:0042445]; lung epithelial cell differentiation [GO:0060487]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of dopaminergic neuron differentiation [GO:1904340]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland stromal morphogenesis [GO:0060741]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory basal cell differentiation [GO:1902691]; response to estradiol [GO:0032355]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; smoothened signaling pathway [GO:0007224]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; alveolar secondary septum development [GO:0061144]; anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral neural tube patterning [GO:0021904]; epithelial cell maturation involved in prostate gland development [GO:0060743]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; epithelial-mesenchymal signaling involved in prostate gland development [GO:0060738]; glucose homeostasis [GO:0042593]; hormone metabolic process [GO:0042445]; lung epithelial cell differentiation [GO:0060487]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of dopaminergic neuron differentiation [GO:1904340]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland stromal morphogenesis [GO:0060741]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory basal cell differentiation [GO:1902691]; response to estradiol [GO:0032355]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:15987773, ECO:0000269|PubMed:16331276}.
P55318	reviewed	FOXA3_HUMAN	Hepatocyte nuclear factor 3-gamma (HNF-3-gamma) (HNF-3G) (Fork head-related protein FKH H3) (Forkhead box protein A3) (Transcription factor 3G) (TCF-3G)	FOXA3 HNF3G TCF3G	Homo sapiens (Human)	350	FUNCTION: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC1 promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. {ECO:0000250, ECO:0000269|PubMed:12695546}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cellular response to starvation [GO:0009267]; chromatin organization [GO:0006325]; hematopoietic stem cell homeostasis [GO:0061484]; intracellular glucose homeostasis [GO:0001678]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cellular response to starvation [GO:0009267]; chromatin organization [GO:0006325]; hematopoietic stem cell homeostasis [GO:0061484]; intracellular glucose homeostasis [GO:0001678]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:19706729}.
P55327	reviewed	TPD52_HUMAN	Tumor protein D52 (Protein N8)	TPD52	Homo sapiens (Human)	224		MISCELLANEOUS: [Isoform 8]: Interacts only with YWHAB and YWHAQ among 14-3-3 proteins. {ECO:0000305}.	anatomical structure morphogenesis [GO:0009653]; B cell differentiation [GO:0030183]; secretion [GO:0046903]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]	calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]; anatomical structure morphogenesis [GO:0009653]; B cell differentiation [GO:0030183]; secretion [GO:0046903]	
P55344	reviewed	LMIP_HUMAN	Lens fiber membrane intrinsic protein (MP18) (MP19) (MP20)	LIM2	Homo sapiens (Human)	173	FUNCTION: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.		cell-cell junction assembly [GO:0007043]; lens development in camera-type eye [GO:0002088]	cell junction [GO:0030054]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	structural constituent of eye lens [GO:0005212]	cell junction [GO:0030054]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; structural constituent of eye lens [GO:0005212]; cell-cell junction assembly [GO:0007043]; lens development in camera-type eye [GO:0002088]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P55345	reviewed	ANM2_HUMAN	Protein arginine N-methyltransferase 2 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT2)	PRMT2 HMT1 HRMT1L1	Homo sapiens (Human)	433	FUNCTION: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. {ECO:0000269|PubMed:12039952, ECO:0000269|PubMed:16648481, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:19405910}.	MISCELLANEOUS: [Isoform PRMT2Alpha]: Higher expression in breast cancer tissues. {ECO:0000305}.; MISCELLANEOUS: [Isoform PRMT2Beta]: Higher expression in breast cancer tissues. Doesn't interact with ESR1. {ECO:0000305}.; MISCELLANEOUS: [Isoform PRMT2Gamma]: Higher expression in breast cancer tissues. {ECO:0000305}.	developmental cell growth [GO:0048588]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; protein methylation [GO:0006479]; regulation of androgen receptor signaling pathway [GO:0060765]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone H3 methyltransferase activity [GO:0140938]; histone H3R8 methyltransferase activity [GO:0140592]; histone methyltransferase activity [GO:0042054]; nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; nuclear progesterone receptor binding [GO:0033142]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear thyroid hormone receptor binding [GO:0046966]; peroxisome proliferator activated receptor binding [GO:0042975]; protein homodimerization activity [GO:0042803]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone H3 methyltransferase activity [GO:0140938]; histone H3R8 methyltransferase activity [GO:0140592]; histone methyltransferase activity [GO:0042054]; nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; nuclear progesterone receptor binding [GO:0033142]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear thyroid hormone receptor binding [GO:0046966]; peroxisome proliferator activated receptor binding [GO:0042975]; protein homodimerization activity [GO:0042803]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; developmental cell growth [GO:0048588]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; protein methylation [GO:0006479]; regulation of androgen receptor signaling pathway [GO:0060765]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.; SUBCELLULAR LOCATION: [Isoform PRMT2Alpha]: Nucleus. Note=Excluded from nucleolus.; SUBCELLULAR LOCATION: [Isoform PRMT2Beta]: Cytoplasm. Nucleus. Nucleus, nucleolus.; SUBCELLULAR LOCATION: [Isoform PRMT2Gamma]: Nucleus. Note=Excluded from nucleolus.; SUBCELLULAR LOCATION: [Isoform PRMT2L2]: Cytoplasm {ECO:0000269|PubMed:21820040}. Nucleus {ECO:0000269|PubMed:21820040}. Note=Predominantly cytoplasmic.
P55347	reviewed	PKNX1_HUMAN	Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1)	PKNOX1 PREP1	Homo sapiens (Human)	436	FUNCTION: Activates transcription in the presence of PBX1A and HOXA1. {ECO:0000250|UniProtKB:O70477}.		angiogenesis [GO:0001525]; camera-type eye development [GO:0043010]; erythrocyte differentiation [GO:0030218]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; angiogenesis [GO:0001525]; camera-type eye development [GO:0043010]; erythrocyte differentiation [GO:0030218]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P55735	reviewed	SEC13_HUMAN	Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein)	SEC13 D3S1231E SEC13A SEC13L1 SEC13R	Homo sapiens (Human)	322	FUNCTION: Functions as a component of the nuclear pore complex (NPC) and the COPII coat (PubMed:8972206). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q9D1M0, ECO:0000269|PubMed:8972206}.; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:25457612, PubMed:23723238, PubMed:27487210, PubMed:36528027, PubMed:35831510). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:36528027, PubMed:35831510). GATOR2 probably acts as a E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}.		cellular response to nutrient levels [GO:0031669]; COPII-coated vesicle budding [GO:0090114]; COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886]; mRNA transport [GO:0051028]; negative regulation of TORC1 signaling [GO:1904262]; nucleocytoplasmic transport [GO:0006913]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein exit from endoplasmic reticulum [GO:0032527]; protein import into nucleus [GO:0006606]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; GATOR2 complex [GO:0061700]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; GATOR2 complex [GO:0061700]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; cellular response to nutrient levels [GO:0031669]; COPII-coated vesicle budding [GO:0090114]; COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886]; mRNA transport [GO:0051028]; negative regulation of TORC1 signaling [GO:1904262]; nucleocytoplasmic transport [GO:0006913]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein exit from endoplasmic reticulum [GO:0032527]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:8972206}; Peripheral membrane protein {ECO:0000269|PubMed:8972206}; Cytoplasmic side {ECO:0000269|PubMed:8972206}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:8972206}; Peripheral membrane protein {ECO:0000269|PubMed:8972206}; Cytoplasmic side {ECO:0000269|PubMed:8972206}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:14517296, ECO:0000269|PubMed:18160040}. Lysosome membrane {ECO:0000269|PubMed:28199306}. Note=In interphase, localizes at both sides of the NPC. {ECO:0000269|PubMed:14517296}.
P55769	reviewed	NH2L1_HUMAN	NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed]	SNU13 NHP2L1	Homo sapiens (Human)	128	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:17412961, PubMed:10545122, PubMed:28781166). {ECO:0000269|PubMed:10545122, ECO:0000269|PubMed:17412961, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:34516797}.		box C/D snoRNP assembly [GO:0000492]; maturation of LSU-rRNA [GO:0000470]; maturation of SSU-rRNA [GO:0030490]; mRNA splicing, via spliceosome [GO:0000398]; ribosomal small subunit biogenesis [GO:0042274]; single fertilization [GO:0007338]	box C/D RNP complex [GO:0031428]; cytosolic large ribosomal subunit [GO:0022625]; dense fibrillar component [GO:0001651]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; protein-containing complex [GO:0032991]; small-subunit processome [GO:0032040]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690]	ATPase binding [GO:0051117]; box C/D RNA binding [GO:0034512]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622]	box C/D RNP complex [GO:0031428]; cytosolic large ribosomal subunit [GO:0022625]; dense fibrillar component [GO:0001651]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; protein-containing complex [GO:0032991]; small-subunit processome [GO:0032040]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690]; ATPase binding [GO:0051117]; box C/D RNA binding [GO:0034512]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622]; box C/D snoRNP assembly [GO:0000492]; maturation of LSU-rRNA [GO:0000470]; maturation of SSU-rRNA [GO:0030490]; mRNA splicing, via spliceosome [GO:0000398]; ribosomal small subunit biogenesis [GO:0042274]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:34516797}. Nucleus, nucleolus {ECO:0000269|PubMed:10593953, ECO:0000269|PubMed:12429849, ECO:0000269|Ref.7}. Note=Concentrated in the dense fibrillar component of the nucleolus. {ECO:0000269|PubMed:10593953}.
P55771	reviewed	PAX9_HUMAN	Paired box protein Pax-9	PAX9	Homo sapiens (Human)	341	FUNCTION: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. {ECO:0000250, ECO:0000269|PubMed:12657635}.		anatomical structure development [GO:0048856]; cellular response to growth factor stimulus [GO:0071363]; endoderm development [GO:0007492]; face morphogenesis [GO:0060325]; negative regulation of DNA-templated transcription [GO:0045892]; odontogenesis [GO:0042476]; regulation of odontogenesis [GO:0042481]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure development [GO:0048856]; cellular response to growth factor stimulus [GO:0071363]; endoderm development [GO:0007492]; face morphogenesis [GO:0060325]; negative regulation of DNA-templated transcription [GO:0045892]; odontogenesis [GO:0042476]; regulation of odontogenesis [GO:0042481]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P55773	reviewed	CCL23_HUMAN	C-C motif chemokine 23 (CK-beta-8) (CKB-8) (Macrophage inflammatory protein 3) (MIP-3) (Myeloid progenitor inhibitory factor 1) (MPIF-1) (Small-inducible cytokine A23) [Cleaved into: CCL23(19-99); CCL23(22-99); CCL23(27-99); CCL23(30-99)]	CCL23 MIP3 MPIF1 SCYA23	Homo sapiens (Human)	120	FUNCTION: Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than CCL23. {ECO:0000269|PubMed:15905581}.		cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; negative regulation of cell population proliferation [GO:0008285]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR1 chemokine receptor binding [GO:0031726]; chemokine activity [GO:0008009]; heparin binding [GO:0008201]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR1 chemokine receptor binding [GO:0031726]; chemokine activity [GO:0008009]; heparin binding [GO:0008201]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; negative regulation of cell population proliferation [GO:0008285]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P55774	reviewed	CCL18_HUMAN	C-C motif chemokine 18 (Alternative macrophage activation-associated CC chemokine 1) (AMAC-1) (CC chemokine PARC) (Dendritic cell chemokine 1) (DC-CK1) (Macrophage inflammatory protein 4) (MIP-4) (Pulmonary and activation-regulated chemokine) (Small-inducible cytokine A18) [Cleaved into: CCL18(1-68); CCL18(3-69); CCL18(4-69)]	CCL18 AMAC1 DCCK1 MIP4 PARC SCYA18	Homo sapiens (Human)	89	FUNCTION: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. {ECO:0000269|PubMed:11745396, ECO:0000269|PubMed:11978786}.		cell communication [GO:0007154]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; signal transduction [GO:0007165]	extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]	extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; cell communication [GO:0007154]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P55786	reviewed	PSA_HUMAN	Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S)	NPEPPS PSA	Homo sapiens (Human)	919	FUNCTION: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501, ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184, ECO:0000269|PubMed:19917696}.		cellular response to hypoxia [GO:0071456]; peptide catabolic process [GO:0043171]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]; cellular response to hypoxia [GO:0071456]; peptide catabolic process [GO:0043171]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10978616}. Nucleus {ECO:0000305}.
P55789	reviewed	ALR_HUMAN	FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) (hERV1) (Hepatopoietin)	GFER ALR HERV1 HPO	Homo sapiens (Human)	205	FUNCTION: [Isoform 1]: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. {ECO:0000269|PubMed:19397338, ECO:0000269|PubMed:20593814, ECO:0000269|PubMed:21383138, ECO:0000269|PubMed:22224850, ECO:0000269|PubMed:23186364, ECO:0000269|PubMed:23676665}.; FUNCTION: [Isoform 2]: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.		cellular response to actinomycin D [GO:0072717]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to toxic substance [GO:0097237]; cellular response to tumor necrosis factor [GO:0071356]; liver development [GO:0001889]; liver regeneration [GO:0097421]; negative regulation of apoptotic process [GO:0043066]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of DNA biosynthetic process [GO:2000573]	cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]	flavin adenine dinucleotide binding [GO:0050660]; flavin-dependent sulfhydryl oxidase activity [GO:0016971]; growth factor activity [GO:0008083]; protein-disulfide reductase activity [GO:0015035]	cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; flavin adenine dinucleotide binding [GO:0050660]; flavin-dependent sulfhydryl oxidase activity [GO:0016971]; growth factor activity [GO:0008083]; protein-disulfide reductase activity [GO:0015035]; cellular response to actinomycin D [GO:0072717]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to toxic substance [GO:0097237]; cellular response to tumor necrosis factor [GO:0071356]; liver development [GO:0001889]; liver regeneration [GO:0097421]; negative regulation of apoptotic process [GO:0043066]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of DNA biosynthetic process [GO:2000573]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion intermembrane space. Mitochondrion {ECO:0000269|PubMed:23676665}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Secreted.
P55795	reviewed	HNRH2_HUMAN	Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]	HNRNPH2 FTP3 HNRPH2	Homo sapiens (Human)	449	FUNCTION: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).		regulation of RNA splicing [GO:0043484]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]	RNA binding [GO:0003723]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; RNA binding [GO:0003723]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:24644279}.
P55809	reviewed	SCOT1_HUMAN	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase)	OXCT1 OXCT SCOT	Homo sapiens (Human)	520	FUNCTION: Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (PubMed:10964512). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). {ECO:0000250|UniProtKB:Q29551, ECO:0000269|PubMed:10964512}.		cellular ketone body metabolic process [GO:0046950]; ketone body catabolic process [GO:0046952]; ketone catabolic process [GO:0042182]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	succinyl-CoA:3-oxo-acid CoA-transferase activity [GO:0008260]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; succinyl-CoA:3-oxo-acid CoA-transferase activity [GO:0008260]; cellular ketone body metabolic process [GO:0046950]; ketone body catabolic process [GO:0046952]; ketone catabolic process [GO:0042182]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:B2GV06}.
P55851	reviewed	UCP2_HUMAN	Dicarboxylate carrier SLC25A8 (Mitochondrial uncoupling protein 2) (UCP 2) (Solute carrier family 25 member 8) (UCPH)	UCP2 SLC25A8	Homo sapiens (Human)	309	FUNCTION: Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle, lowering the ATP/ADP ratio and reactive oxygen species (ROS) production (PubMed:24395786). Proton transporter activity is debated, but if it occurs it may mediate inducible proton re-entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. Proton re-entry may be coupled to metabolite transport to allow for proton flux switching and optimal ATP turnover (PubMed:11171965, PubMed:33373220, PubMed:11278935, PubMed:22524567, PubMed:26182433) (By similarity). Regulates the use of glucose as a source of energy. Required for glucose-induced DRP1-dependent mitochondrial fission and neuron activation in the ventromedial nucleus of the hypothalamus (VMH). This mitochondrial adaptation mechanism modulates the VMH pool of glucose-excited neurons with an impact on systemic glucose homeostasis (By similarity). Regulates ROS levels and metabolic reprogramming of macrophages during the resolution phase of inflammation. Attenuates ROS production in response to IL33 to preserve the integrity of the Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). Can unidirectionally transport anions including L-malate, L-aspartate, phosphate and chloride ions (PubMed:24395786, PubMed:22524567, PubMed:26182433). Does not mediate adaptive thermogenesis (By similarity). {ECO:0000250|UniProtKB:P70406, ECO:0000269|PubMed:11171965, ECO:0000269|PubMed:11278935, ECO:0000269|PubMed:24395786, ECO:0000269|PubMed:33373220}.		adaptive thermogenesis [GO:1990845]; C4-dicarboxylate transport [GO:0015740]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to lead ion [GO:0071284]; female pregnancy [GO:0007565]; glutamine metabolic process [GO:0006541]; glycolytic process [GO:0006096]; liver regeneration [GO:0097421]; macrophage differentiation [GO:0030225]; mitochondrial fission [GO:0000266]; mitochondrial transmembrane transport [GO:1990542]; mitochondrial transport [GO:0006839]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cold-induced thermogenesis [GO:0120162]; proton transmembrane transport [GO:1902600]; reactive oxygen species metabolic process [GO:0072593]; regulation of mitochondrial membrane potential [GO:0051881]; response to cold [GO:0009409]; response to fatty acid [GO:0070542]; response to hypoxia [GO:0001666]; response to superoxide [GO:0000303]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	antiporter activity [GO:0015297]; chloride transmembrane transporter activity [GO:0015108]; L-aspartate transmembrane transporter activity [GO:0015183]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; oxidative phosphorylation uncoupler activity [GO:0017077]; phosphate ion uniporter activity [GO:0140787]; protein homodimerization activity [GO:0042803]; proton transmembrane transporter activity [GO:0015078]; secondary active sulfate transmembrane transporter activity [GO:0008271]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; antiporter activity [GO:0015297]; chloride transmembrane transporter activity [GO:0015108]; L-aspartate transmembrane transporter activity [GO:0015183]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; oxidative phosphorylation uncoupler activity [GO:0017077]; phosphate ion uniporter activity [GO:0140787]; protein homodimerization activity [GO:0042803]; proton transmembrane transporter activity [GO:0015078]; secondary active sulfate transmembrane transporter activity [GO:0008271]; adaptive thermogenesis [GO:1990845]; C4-dicarboxylate transport [GO:0015740]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to lead ion [GO:0071284]; female pregnancy [GO:0007565]; glutamine metabolic process [GO:0006541]; glycolytic process [GO:0006096]; liver regeneration [GO:0097421]; macrophage differentiation [GO:0030225]; mitochondrial fission [GO:0000266]; mitochondrial transmembrane transport [GO:1990542]; mitochondrial transport [GO:0006839]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cold-induced thermogenesis [GO:0120162]; proton transmembrane transport [GO:1902600]; reactive oxygen species metabolic process [GO:0072593]; regulation of mitochondrial membrane potential [GO:0051881]; response to cold [GO:0009409]; response to fatty acid [GO:0070542]; response to hypoxia [GO:0001666]; response to superoxide [GO:0000303]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P70406}; Multi-pass membrane protein {ECO:0000255}.
P55854	reviewed	SUMO3_HUMAN	Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)	SUMO3 SMT3A SMT3H1	Homo sapiens (Human)	103	FUNCTION: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678}.		negative regulation of DNA binding [GO:0043392]; protein sumoylation [GO:0016925]; regulation of protein localization to nucleus [GO:1900180]	cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	protein tag activity [GO:0031386]; ubiquitin-like protein ligase binding [GO:0044389]	cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein tag activity [GO:0031386]; ubiquitin-like protein ligase binding [GO:0044389]; negative regulation of DNA binding [GO:0043392]; protein sumoylation [GO:0016925]; regulation of protein localization to nucleus [GO:1900180]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body {ECO:0000250}.
P55884	reviewed	EIF3B_HUMAN	Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116)	EIF3B EIF3S9	Homo sapiens (Human)	814	FUNCTION: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.		formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; synapse [GO:0045202]	molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; synapse [GO:0045202]; molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]; formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}. Cytoplasm, Stress granule {ECO:0000269|PubMed:17984221}. Note=Localizes to stress granules following cellular stress. {ECO:0000269|PubMed:17984221}.
P55895	reviewed	RAG2_HUMAN	V(D)J recombination-activating protein 2 (RAG-2)	RAG2	Homo sapiens (Human)	527	FUNCTION: Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity). {ECO:0000250}.		B cell differentiation [GO:0030183]; B cell homeostatic proliferation [GO:0002358]; B cell lineage commitment [GO:0002326]; chromatin organization [GO:0006325]; defense response to bacterium [GO:0042742]; DN2 thymocyte differentiation [GO:1904155]; mature B cell differentiation involved in immune response [GO:0002313]; negative regulation of T cell differentiation in thymus [GO:0033085]; organ growth [GO:0035265]; positive regulation of organ growth [GO:0046622]; pre-B cell allelic exclusion [GO:0002331]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; V(D)J recombination [GO:0033151]	DNA recombinase complex [GO:0097519]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	DNA recombinase complex [GO:0097519]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; B cell differentiation [GO:0030183]; B cell homeostatic proliferation [GO:0002358]; B cell lineage commitment [GO:0002326]; chromatin organization [GO:0006325]; defense response to bacterium [GO:0042742]; DN2 thymocyte differentiation [GO:1904155]; mature B cell differentiation involved in immune response [GO:0002313]; negative regulation of T cell differentiation in thymus [GO:0033085]; organ growth [GO:0035265]; positive regulation of organ growth [GO:0046622]; pre-B cell allelic exclusion [GO:0002331]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; V(D)J recombination [GO:0033151]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P55899	reviewed	FCGRN_HUMAN	IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)	FCGRT FCRN	Homo sapiens (Human)	365	FUNCTION: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995). {ECO:0000250|UniProtKB:P13599, ECO:0000269|PubMed:10933786, ECO:0000269|PubMed:10998088, ECO:0000269|PubMed:24469444, ECO:0000269|PubMed:28330995, ECO:0000269|PubMed:7964511}.; FUNCTION: (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29. {ECO:0000269|PubMed:30808762, ECO:0000269|PubMed:31104841}.		IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor [GO:0002416]; immune response [GO:0006955]	endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]	beta-2-microglobulin binding [GO:0030881]; IgG binding [GO:0019864]	endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; beta-2-microglobulin binding [GO:0030881]; IgG binding [GO:0019864]; IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor [GO:0002416]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13599}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:31104841}.
P55916	reviewed	UCP3_HUMAN	Putative mitochondrial transporter UCP3 (Solute carrier family 25 member 9) (Uncoupling protein-3) (UCP 3)	UCP3 SLC25A9	Homo sapiens (Human)	312	FUNCTION: Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed:21775425, PubMed:36114012). Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis (PubMed:9305858, PubMed:11171965, PubMed:12670931, PubMed:12734183). However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity (PubMed:11707458). {ECO:0000269|PubMed:11171965, ECO:0000269|PubMed:11707458, ECO:0000269|PubMed:12670931, ECO:0000269|PubMed:12734183, ECO:0000269|PubMed:21775425, ECO:0000269|PubMed:36114012, ECO:0000269|PubMed:9305858}.		adaptive thermogenesis [GO:1990845]; cellular response to hormone stimulus [GO:0032870]; fatty acid metabolic process [GO:0006631]; lipid hydroperoxide transport [GO:1901373]; lipid metabolic process [GO:0006629]; mitochondrial transmembrane transport [GO:1990542]; mitochondrial transport [GO:0006839]; proton transmembrane transport [GO:1902600]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to activity [GO:0014823]; response to cold [GO:0009409]; response to glucocorticoid [GO:0051384]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to nutrient [GO:0007584]; response to superoxide [GO:0000303]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	oxidative phosphorylation uncoupler activity [GO:0017077]; proton transmembrane transporter activity [GO:0015078]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; oxidative phosphorylation uncoupler activity [GO:0017077]; proton transmembrane transporter activity [GO:0015078]; adaptive thermogenesis [GO:1990845]; cellular response to hormone stimulus [GO:0032870]; fatty acid metabolic process [GO:0006631]; lipid hydroperoxide transport [GO:1901373]; lipid metabolic process [GO:0006629]; mitochondrial transmembrane transport [GO:1990542]; mitochondrial transport [GO:0006839]; proton transmembrane transport [GO:1902600]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to activity [GO:0014823]; response to cold [GO:0009409]; response to glucocorticoid [GO:0051384]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to nutrient [GO:0007584]; response to superoxide [GO:0000303]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P56501}; Multi-pass membrane protein {ECO:0000255}.
P55957	reviewed	BID_HUMAN	BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]	BID	Homo sapiens (Human)	195	FUNCTION: Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Allows the release of cytochrome c (PubMed:32029622). {ECO:0000269|PubMed:15661737, ECO:0000269|PubMed:32029622}.; FUNCTION: [Isoform 1]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 2]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 3]: Does not induce apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 4]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.		apoptotic mitochondrial changes [GO:0008637]; establishment of protein localization to membrane [GO:0090150]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial outer membrane permeabilization [GO:0097345]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein targeting to mitochondrion [GO:0006626]; protein-containing complex assembly [GO:0065003]; regulation of epithelial cell proliferation [GO:0050678]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of T cell proliferation [GO:0042129]; release of cytochrome c from mitochondria [GO:0001836]; signal transduction in response to DNA damage [GO:0042770]; supramolecular fiber organization [GO:0097435]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	cysteine-type endopeptidase regulator activity involved in apoptotic process [GO:0043028]; death receptor binding [GO:0005123]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; cysteine-type endopeptidase regulator activity involved in apoptotic process [GO:0043028]; death receptor binding [GO:0005123]; ubiquitin protein ligase binding [GO:0031625]; apoptotic mitochondrial changes [GO:0008637]; establishment of protein localization to membrane [GO:0090150]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial outer membrane permeabilization [GO:0097345]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein targeting to mitochondrion [GO:0006626]; protein-containing complex assembly [GO:0065003]; regulation of epithelial cell proliferation [GO:0050678]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of T cell proliferation [GO:0042129]; release of cytochrome c from mitochondria [GO:0001836]; signal transduction in response to DNA damage [GO:0042770]; supramolecular fiber organization [GO:0097435]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14583606}. Mitochondrion membrane {ECO:0000269|PubMed:14583606}. Mitochondrion outer membrane {ECO:0000269|PubMed:29531808}. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269|PubMed:14583606}.; SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p15]: Mitochondrion membrane {ECO:0000250|UniProtKB:P70444}. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250|UniProtKB:P70444}.; SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p13]: Mitochondrion membrane {ECO:0000250|UniProtKB:P70444}. Note=Associated with the mitochondrial membrane. {ECO:0000250|UniProtKB:P70444}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:14583606}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:14583606}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion membrane {ECO:0000269|PubMed:14583606}. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. {ECO:0000269|PubMed:14583606}.
P56134	reviewed	ATPK_HUMAN	ATP synthase subunit f, mitochondrial (ATP synthase membrane subunit f)	ATP5MF ATP5J2 ATP5JL	Homo sapiens (Human)	94	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.		proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]		mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600]	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P56159	reviewed	GFRA1_HUMAN	GDNF family receptor alpha-1 (GDNF receptor alpha-1) (GDNFR-alpha-1) (GFR-alpha-1) (RET ligand 1) (TGF-beta-related neurotrophic factor receptor 1)	GFRA1 GDNFRA RETL1 TRNR1	Homo sapiens (Human)	465	FUNCTION: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity). {ECO:0000250|UniProtKB:Q62997}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; kidney development [GO:0001822]; male gonad development [GO:0008584]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]	axon [GO:0030424]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; Golgi apparatus [GO:0005794]; multivesicular body [GO:0005771]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; receptor complex [GO:0043235]	glial cell-derived neurotrophic factor receptor activity [GO:0016167]; integrin binding [GO:0005178]; neurotrophin receptor activity [GO:0005030]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]	axon [GO:0030424]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; Golgi apparatus [GO:0005794]; multivesicular body [GO:0005771]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; receptor complex [GO:0043235]; glial cell-derived neurotrophic factor receptor activity [GO:0016167]; integrin binding [GO:0005178]; neurotrophin receptor activity [GO:0005030]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; kidney development [GO:0001822]; male gonad development [GO:0008584]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q62997}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q62997}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q62997}. Endosome {ECO:0000250|UniProtKB:Q62997}. Endosome, multivesicular body {ECO:0000250|UniProtKB:Q62997}. Note=Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies. {ECO:0000250|UniProtKB:Q62997}.
P56177	reviewed	DLX1_HUMAN	Homeobox protein DLX-1	DLX1	Homo sapiens (Human)	255	FUNCTION: Plays a role as a transcriptional activator or repressor (PubMed:14671321). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity). {ECO:0000250|UniProtKB:Q64317, ECO:0000269|PubMed:14671321}.		cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cerebral cortex GABAergic interneuron fate commitment [GO:0021893]; embryonic skeletal system development [GO:0048706]; forebrain neuron differentiation [GO:0021879]; hippocampus development [GO:0021766]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast differentiation [GO:0014016]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; positive regulation of amacrine cell differentiation [GO:1902871]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; subpallium development [GO:0021544]	chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cerebral cortex GABAergic interneuron fate commitment [GO:0021893]; embryonic skeletal system development [GO:0048706]; forebrain neuron differentiation [GO:0021879]; hippocampus development [GO:0021766]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast differentiation [GO:0014016]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; positive regulation of amacrine cell differentiation [GO:1902871]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; subpallium development [GO:0021544]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14671321}.
P56178	reviewed	DLX5_HUMAN	Homeobox protein DLX-5	DLX5	Homo sapiens (Human)	289	FUNCTION: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. {ECO:0000269|PubMed:19497851}.		anatomical structure formation involved in morphogenesis [GO:0048646]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cellular response to BMP stimulus [GO:0071773]; embryonic limb morphogenesis [GO:0030326]; endochondral ossification [GO:0001958]; epithelial cell differentiation [GO:0030855]; face morphogenesis [GO:0060325]; inner ear morphogenesis [GO:0042472]; interneuron axon guidance [GO:0097376]; nervous system development [GO:0007399]; olfactory bulb interneuron differentiation [GO:0021889]; olfactory pit development [GO:0060166]; osteoblast differentiation [GO:0001649]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure formation involved in morphogenesis [GO:0048646]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cellular response to BMP stimulus [GO:0071773]; embryonic limb morphogenesis [GO:0030326]; endochondral ossification [GO:0001958]; epithelial cell differentiation [GO:0030855]; face morphogenesis [GO:0060325]; inner ear morphogenesis [GO:0042472]; interneuron axon guidance [GO:0097376]; nervous system development [GO:0007399]; olfactory bulb interneuron differentiation [GO:0021889]; olfactory pit development [GO:0060166]; osteoblast differentiation [GO:0001649]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
P56180	reviewed	TPTE_HUMAN	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Cancer/testis antigen 44) (CT44) (Transmembrane phosphatase with tensin homology) (Tumor antigen BJ-HCC-5)	TPTE	Homo sapiens (Human)	551	FUNCTION: Could be involved in signal transduction.		dephosphorylation [GO:0016311]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	cytosol [GO:0005829]; membrane [GO:0016020]	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; protein tyrosine phosphatase activity [GO:0004725]	cytosol [GO:0005829]; membrane [GO:0016020]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; protein tyrosine phosphatase activity [GO:0004725]; dephosphorylation [GO:0016311]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P56181	reviewed	NDUV3_HUMAN	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) (Renal carcinoma antigen NY-REN-4)	NDUFV3	Homo sapiens (Human)	108	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]; RNA binding [GO:0003723]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; RNA binding [GO:0003723]; aerobic respiration [GO:0009060]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
P56182	reviewed	RRP1_HUMAN	Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein)	RRP1 D21S2056E NNP1 NOP52 RRP1A	Homo sapiens (Human)	461	FUNCTION: Plays a critical role in the generation of 28S rRNA. {ECO:0000269|PubMed:10341208}.		rRNA processing [GO:0006364]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]	RNA binding [GO:0003723]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]; RNA binding [GO:0003723]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:9192856}.
P56192	reviewed	SYMC_HUMAN	Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)	MARS1 MARS	Homo sapiens (Human)	900	FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971). {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:11714285, ECO:0000269|PubMed:33909043}.		cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; methionyl-tRNA aminoacylation [GO:0006431]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; rRNA transcription [GO:0009303]; tRNA aminoacylation for protein translation [GO:0006418]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]	ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]; tRNA binding [GO:0000049]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]; tRNA binding [GO:0000049]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; methionyl-tRNA aminoacylation [GO:0006431]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; rRNA transcription [GO:0009303]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:19289464, ECO:0000305|PubMed:26472928}. Nucleus, nucleolus {ECO:0000269|PubMed:10791971}. Note=Localizes to the nucleolus in proliferative cells but disappears in quiescent cells. {ECO:0000269|PubMed:10791971}.
P56199	reviewed	ITA1_HUMAN	Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a)	ITGA1	Homo sapiens (Human)	1179	FUNCTION: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. {ECO:0000269|PubMed:15592458}.		cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular extravasation [GO:0045123]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; neuron projection morphogenesis [GO:0048812]; neutrophil chemotaxis [GO:0030593]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; vasodilation [GO:0042311]	acrosomal vesicle [GO:0001669]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alpha1-beta1 complex [GO:0034665]; integrin complex [GO:0008305]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]	collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; protein phosphatase binding [GO:0019903]	acrosomal vesicle [GO:0001669]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alpha1-beta1 complex [GO:0034665]; integrin complex [GO:0008305]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; protein phosphatase binding [GO:0019903]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular extravasation [GO:0045123]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; neuron projection morphogenesis [GO:0048812]; neutrophil chemotaxis [GO:0030593]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P56202	reviewed	CATW_HUMAN	Cathepsin W (EC 3.4.22.-) (Lymphopain)	CTSW	Homo sapiens (Human)	376	FUNCTION: May have a specific function in the mechanism or regulation of T-cell cytolytic activity.; FUNCTION: (Microbial infection) Plays a role during influenza virus infection in lungs cells ex vivo. Acts at the level of virus entering host cytoplasm from late endosome. {ECO:0000269|PubMed:15340161}.		immune response [GO:0006955]; proteolysis involved in protein catabolic process [GO:0051603]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet dense granule lumen [GO:0031089]	cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet dense granule lumen [GO:0031089]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; immune response [GO:0006955]; proteolysis involved in protein catabolic process [GO:0051603]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:11490002}.
P56211	reviewed	ARP19_HUMAN	cAMP-regulated phosphoprotein 19 (ARPP-19)	ARPP19	Homo sapiens (Human)	112	FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. {ECO:0000269|PubMed:21164014}.		cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of glucose import [GO:0046326]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	phosphatase inhibitor activity [GO:0019212]; potassium channel regulator activity [GO:0015459]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; phosphatase inhibitor activity [GO:0019212]; potassium channel regulator activity [GO:0015459]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]; signaling receptor binding [GO:0005102]; cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of glucose import [GO:0046326]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
P56270	reviewed	MAZ_HUMAN	Myc-associated zinc finger protein (MAZI) (Pur-1) (Purine-binding transcription factor) (Serum amyloid A-activating factor-1) (SAF-1) (Transcription factor Zif87) (ZF87) (Zinc finger protein 801)	MAZ ZNF801	Homo sapiens (Human)	477	FUNCTION: Transcriptional regulator, potentially with dual roles in transcription initiation and termination. {ECO:0000303|PubMed:1502157}.; FUNCTION: [Isoform 1]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157). Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157). {ECO:0000269|PubMed:12270922, ECO:0000269|PubMed:1502157}.; FUNCTION: [Isoform 2]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922). {ECO:0000269|PubMed:12270922}.; FUNCTION: [Isoform 3]: Binds DNA and functions as a transcriptional activator. {ECO:0000269|PubMed:19583771}.	MISCELLANEOUS: [Isoform 2]: May act as a dominant negative of isoform 1. Reduced expression during inflammatory conditions. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: The transactivation potential of isoform 3 is much greater than that of the predominantly expressed isoform 1. {ECO:0000269|PubMed:19583771}.	negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of transcription by RNA polymerase II [GO:0006357]; termination of RNA polymerase II transcription [GO:0006369]; transcription initiation at RNA polymerase II promoter [GO:0006367]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of transcription by RNA polymerase II [GO:0006357]; termination of RNA polymerase II transcription [GO:0006369]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:10727212}. Note=In brains of Alzheimer disease patients, present in a plaque-like structures.
P56278	reviewed	MTCP1_HUMAN	Protein p13 MTCP-1 (p13MTCP1) (Mature T-cell proliferation-1 type B1) (MTCP-1 type B1)	MTCP1 C6.1B	Homo sapiens (Human)	107	FUNCTION: Enhances the phosphorylation and activation of AKT1 and AKT2. {ECO:0000269|PubMed:10983986}.	MISCELLANEOUS: [Isoform 2]: Shares a non-coding 5' exon with isoform 1 which is spliced to a different set of 3' exons encoding an unrelated protein.	positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein serine/threonine kinase activity [GO:0071902]	protein-containing complex [GO:0032991]	protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]	protein-containing complex [GO:0032991]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein serine/threonine kinase activity [GO:0071902]	
P56279	reviewed	TCL1A_HUMAN	T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)	TCL1A TCL1	Homo sapiens (Human)	114	FUNCTION: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. {ECO:0000269|PubMed:10716693, ECO:0000269|PubMed:10983986, ECO:0000269|PubMed:11707444, ECO:0000269|PubMed:11839817}.		cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein-containing complex assembly [GO:0031334]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein-containing complex assembly [GO:0031334]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Microsome {ECO:0000269|PubMed:7987816}. Endoplasmic reticulum {ECO:0000269|PubMed:7987816}. Note=Microsomal fraction.
P56282	reviewed	DPOE2_HUMAN	DNA polymerase epsilon subunit 2 (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B)	POLE2 DPE2	Homo sapiens (Human)	527	FUNCTION: Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). {ECO:0000250|UniProtKB:P24482, ECO:0000269|PubMed:10801849}.	MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.	DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276]	epsilon DNA polymerase complex [GO:0008622]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]	epsilon DNA polymerase complex [GO:0008622]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276]	SUBCELLULAR LOCATION: Nucleus.
P56373	reviewed	P2RX3_HUMAN	P2X purinoceptor 3 (P2X3) (ATP receptor) (Purinergic receptor)	P2RX3	Homo sapiens (Human)	397	FUNCTION: Receptor for ATP that acts as a ligand-gated cation channel (PubMed:27626375). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity). {ECO:0000250|UniProtKB:Q3UR32, ECO:0000269|PubMed:27626375}.		behavioral response to pain [GO:0048266]; calcium ion transmembrane transport [GO:0070588]; cellular response to ATP [GO:0071318]; establishment of localization in cell [GO:0051649]; inorganic cation transmembrane transport [GO:0098662]; neuromuscular synaptic transmission [GO:0007274]; peristalsis [GO:0030432]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; protein homotrimerization [GO:0070207]; regulation of synaptic plasticity [GO:0048167]; response to carbohydrate [GO:0009743]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; sensory perception of taste [GO:0050909]; signal transduction [GO:0007165]; urinary bladder smooth muscle contraction [GO:0014832]	axon [GO:0030424]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235]; Schaffer collateral - CA1 synapse [GO:0098685]	ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; purinergic nucleotide receptor activity [GO:0001614]	axon [GO:0030424]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235]; Schaffer collateral - CA1 synapse [GO:0098685]; ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; purinergic nucleotide receptor activity [GO:0001614]; behavioral response to pain [GO:0048266]; calcium ion transmembrane transport [GO:0070588]; cellular response to ATP [GO:0071318]; establishment of localization in cell [GO:0051649]; inorganic cation transmembrane transport [GO:0098662]; neuromuscular synaptic transmission [GO:0007274]; peristalsis [GO:0030432]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; protein homotrimerization [GO:0070207]; regulation of synaptic plasticity [GO:0048167]; response to carbohydrate [GO:0009743]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; sensory perception of taste [GO:0050909]; signal transduction [GO:0007165]; urinary bladder smooth muscle contraction [GO:0014832]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27626375}; Multi-pass membrane protein {ECO:0000269|PubMed:27626375}.
P56377	reviewed	AP1S2_HUMAN	AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin)	AP1S2 DC22	Homo sapiens (Human)	157	FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.		intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; vesicle-mediated transport [GO:0016192]	AP-1 adaptor complex [GO:0030121]; AP-type membrane coat adaptor complex [GO:0030119]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]	clathrin adaptor activity [GO:0035615]	AP-1 adaptor complex [GO:0030121]; AP-type membrane coat adaptor complex [GO:0030119]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]; clathrin adaptor activity [GO:0035615]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
P56381	reviewed	ATP5E_HUMAN	ATP synthase subunit epsilon, mitochondrial (ATPase subunit epsilon) (ATP synthase F1 subunit epsilon)	ATP5F1E ATP5E	Homo sapiens (Human)	51	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity). {ECO:0000250}.		proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) [GO:0000275]	hydrolase activity [GO:0016787]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) [GO:0000275]; hydrolase activity [GO:0016787]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane.
P56470	reviewed	LEG4_HUMAN	Galectin-4 (Gal-4) (Antigen NY-CO-27) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4)	LGALS4	Homo sapiens (Human)	323	FUNCTION: Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.		antibacterial peptide biosynthetic process [GO:0002780]; cell adhesion [GO:0007155]	collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936]	collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936]; antibacterial peptide biosynthetic process [GO:0002780]; cell adhesion [GO:0007155]	
P56524	reviewed	HDAC4_HUMAN	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	HDAC4 KIAA0288	Homo sapiens (Human)	1084	FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}.		B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; cardiac muscle hypertrophy in response to stress [GO:0014898]; chromatin remodeling [GO:0006338]; inflammatory response [GO:0006954]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of glycolytic process [GO:0045820]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; protein sumoylation [GO:0016925]; regulation of protein binding [GO:0043393]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to interleukin-1 [GO:0070555]; type I interferon-mediated signaling pathway [GO:0060337]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; potassium ion binding [GO:0030955]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SUMO transferase activity [GO:0019789]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; potassium ion binding [GO:0030955]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SUMO transferase activity [GO:0019789]; zinc ion binding [GO:0008270]; B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; cardiac muscle hypertrophy in response to stress [GO:0014898]; chromatin remodeling [GO:0006338]; inflammatory response [GO:0006954]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of glycolytic process [GO:0045820]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; protein sumoylation [GO:0016925]; regulation of protein binding [GO:0043393]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to interleukin-1 [GO:0070555]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q6NZM9}.
P56537	reviewed	IF6_HUMAN	Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP))	EIF6 EIF3A ITGB4BP OK/SW-cl.27	Homo sapiens (Human)	245	FUNCTION: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:21536732, ECO:0000269|PubMed:32669547}.		assembly of large subunit precursor of preribosome [GO:1902626]; cytosolic ribosome assembly [GO:0042256]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of translation [GO:0045727]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of glycolytic process [GO:0006110]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to insulin [GO:0032868]; ribosomal subunit export from nucleus [GO:0000054]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamin filament [GO:0005638]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; synapse [GO:0045202]	ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamin filament [GO:0005638]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; synapse [GO:0045202]; ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]; assembly of large subunit precursor of preribosome [GO:1902626]; cytosolic ribosome assembly [GO:0042256]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of translation [GO:0045727]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of glycolytic process [GO:0006110]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to insulin [GO:0032868]; ribosomal subunit export from nucleus [GO:0000054]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
P56539	reviewed	CAV3_HUMAN	Caveolin-3 (M-caveolin)	CAV3	Homo sapiens (Human)	151	FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (PubMed:19262564). {ECO:0000250|UniProtKB:P51637, ECO:0000269|PubMed:19262564}.		actin filament organization [GO:0007015]; calcium ion transport [GO:0006816]; cardiac muscle cell development [GO:0055013]; cardiac muscle hypertrophy [GO:0003300]; caveola assembly [GO:0070836]; cell differentiation [GO:0030154]; cellular response to organonitrogen compound [GO:0071417]; cholesterol homeostasis [GO:0042632]; cytoplasmic microtubule organization [GO:0031122]; detection of muscle stretch [GO:0035995]; endocytosis [GO:0006897]; establishment of localization in cell [GO:0051649]; glucose homeostasis [GO:0042593]; heart trabecula formation [GO:0060347]; MAPK cascade [GO:0000165]; membrane raft organization [GO:0031579]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of cell size [GO:0045792]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900826]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sarcomere organization [GO:0060299]; nucleus localization [GO:0051647]; plasma membrane organization [GO:0007009]; plasma membrane repair [GO:0001778]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein localization [GO:0008104]; protein localization to plasma membrane [GO:0072659]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of calcium ion import [GO:0090279]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart contraction [GO:0008016]; regulation of heart rate [GO:0002027]; regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900825]; regulation of membrane potential [GO:0042391]; regulation of nerve growth factor receptor activity [GO:0051394]; regulation of p38MAPK cascade [GO:1900744]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of signal transduction by receptor internalization [GO:0038009]; regulation of skeletal muscle contraction [GO:0014819]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; T-tubule organization [GO:0033292]; triglyceride metabolic process [GO:0006641]; ventricular cardiac muscle cell action potential [GO:0086005]	caveola [GO:0005901]; cell surface [GO:0009986]; dystrophin-associated glycoprotein complex [GO:0016010]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; vesicle [GO:0031982]; Z disc [GO:0030018]	alpha-tubulin binding [GO:0043014]; calcium channel regulator activity [GO:0005246]; connexin binding [GO:0071253]; molecular adaptor activity [GO:0060090]; nitric-oxide synthase binding [GO:0050998]; potassium channel inhibitor activity [GO:0019870]; protein-containing complex binding [GO:0044877]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]	caveola [GO:0005901]; cell surface [GO:0009986]; dystrophin-associated glycoprotein complex [GO:0016010]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; vesicle [GO:0031982]; Z disc [GO:0030018]; alpha-tubulin binding [GO:0043014]; calcium channel regulator activity [GO:0005246]; connexin binding [GO:0071253]; molecular adaptor activity [GO:0060090]; nitric-oxide synthase binding [GO:0050998]; potassium channel inhibitor activity [GO:0019870]; protein-containing complex binding [GO:0044877]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; actin filament organization [GO:0007015]; calcium ion transport [GO:0006816]; cardiac muscle cell development [GO:0055013]; cardiac muscle hypertrophy [GO:0003300]; caveola assembly [GO:0070836]; cell differentiation [GO:0030154]; cellular response to organonitrogen compound [GO:0071417]; cholesterol homeostasis [GO:0042632]; cytoplasmic microtubule organization [GO:0031122]; detection of muscle stretch [GO:0035995]; endocytosis [GO:0006897]; establishment of localization in cell [GO:0051649]; glucose homeostasis [GO:0042593]; heart trabecula formation [GO:0060347]; MAPK cascade [GO:0000165]; membrane raft organization [GO:0031579]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of cell size [GO:0045792]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900826]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sarcomere organization [GO:0060299]; nucleus localization [GO:0051647]; plasma membrane organization [GO:0007009]; plasma membrane repair [GO:0001778]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein localization [GO:0008104]; protein localization to plasma membrane [GO:0072659]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of calcium ion import [GO:0090279]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart contraction [GO:0008016]; regulation of heart rate [GO:0002027]; regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900825]; regulation of membrane potential [GO:0042391]; regulation of nerve growth factor receptor activity [GO:0051394]; regulation of p38MAPK cascade [GO:1900744]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of signal transduction by receptor internalization [GO:0038009]; regulation of skeletal muscle contraction [GO:0014819]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; T-tubule organization [GO:0033292]; triglyceride metabolic process [GO:0006641]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P51638}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250|UniProtKB:P51637}; Peripheral membrane protein {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P51637}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.
P56545	reviewed	CTBP2_HUMAN	C-terminal-binding protein 2 (CtBP2)	CTBP2	Homo sapiens (Human)	445	FUNCTION: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). {ECO:0000250}.; FUNCTION: Isoform 2 probably acts as a scaffold for specialized synapses.		cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; synaptic vesicle docking [GO:0016081]; viral genome replication [GO:0019079]; white fat cell differentiation [GO:0050872]	GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; photoreceptor ribbon synapse [GO:0098684]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic cytosol [GO:0099523]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; nuclear retinoic acid receptor binding [GO:0042974]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; structural constituent of presynaptic active zone [GO:0098882]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]	GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; photoreceptor ribbon synapse [GO:0098684]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic cytosol [GO:0099523]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; nuclear retinoic acid receptor binding [GO:0042974]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; structural constituent of presynaptic active zone [GO:0098882]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; synaptic vesicle docking [GO:0016081]; viral genome replication [GO:0019079]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Synapse {ECO:0000250}.
P56556	reviewed	NDUA6_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Complex I-B14) (CI-B14) (LYR motif-containing protein 6) (NADH-ubiquinone oxidoreductase B14 subunit)	NDUFA6 LYRM6 NADHB14	Homo sapiens (Human)	128	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly (PubMed:30245030). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:30245030}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to oxidative stress [GO:0006979]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
P56557	reviewed	TM50B_HUMAN	Transmembrane protein 50B (HCV p7-trans-regulated protein 3)	TMEM50B C21orf4 UNQ167/PRO193	Homo sapiens (Human)	158			late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D1X9}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9D1X9}; Multi-pass membrane protein {ECO:0000255}.
P56559	reviewed	ARL4C_HUMAN	ADP-ribosylation factor-like protein 4C (ADP-ribosylation factor-like protein 7) (ADP-ribosylation factor-like protein LAK)	ARL4C ARL7	Homo sapiens (Human)	192	FUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process. {ECO:0000269|PubMed:15147902, ECO:0000269|PubMed:17398095, ECO:0000269|PubMed:19409876}.		endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	alpha-tubulin binding [GO:0043014]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; alpha-tubulin binding [GO:0043014]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cell projection, filopodium. Cell membrane. Cytoplasm.
P56589	reviewed	PEX3_HUMAN	Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3)	PEX3	Homo sapiens (Human)	373	FUNCTION: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes. {ECO:0000269|PubMed:10848631, ECO:0000269|PubMed:15007061}.		peroxisome organization [GO:0007031]; protein import into peroxisome membrane [GO:0045046]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; protein-lipid complex [GO:0032994]	lipid binding [GO:0008289]; protein-macromolecule adaptor activity [GO:0030674]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; protein-lipid complex [GO:0032994]; lipid binding [GO:0008289]; protein-macromolecule adaptor activity [GO:0030674]; peroxisome organization [GO:0007031]; protein import into peroxisome membrane [GO:0045046]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:10848631, ECO:0000269|PubMed:11390669, ECO:0000269|PubMed:21768384}; Multi-pass membrane protein {ECO:0000269|PubMed:11390669}.
P56597	reviewed	NDK5_HUMAN	Nucleoside diphosphate kinase homolog 5 (NDK-H 5) (NDP kinase homolog 5) (Inhibitor of p53-induced apoptosis-beta) (IPIA-beta) (Testis-specific nm23 homolog) (nm23-H5)	NME5	Homo sapiens (Human)	212	FUNCTION: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). {ECO:0000250|UniProtKB:Q6DGQ8, ECO:0000250|UniProtKB:Q99MH5}.		cilium assembly [GO:0060271]; cilium movement [GO:0003341]; CTP biosynthetic process [GO:0006241]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; GTP biosynthetic process [GO:0006183]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; nucleoside metabolic process [GO:0009116]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; UTP biosynthetic process [GO:0006228]; ventricular system development [GO:0021591]	9+2 motile cilium [GO:0097729]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; sperm flagellum [GO:0036126]	nucleoside diphosphate kinase activity [GO:0004550]	9+2 motile cilium [GO:0097729]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; sperm flagellum [GO:0036126]; nucleoside diphosphate kinase activity [GO:0004550]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; CTP biosynthetic process [GO:0006241]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; GTP biosynthetic process [GO:0006183]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; nucleoside metabolic process [GO:0009116]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; UTP biosynthetic process [GO:0006228]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q99MH5}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q99MH5}.
P56645	reviewed	PER3_HUMAN	Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3)	PER3 GIG13	Homo sapiens (Human)	1201	FUNCTION: Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269|PubMed:17346965, ECO:0000269|PubMed:19716732, ECO:0000269|PubMed:24439663, ECO:0000269|PubMed:24577121, ECO:0000269|PubMed:26903630}.		circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	kinase binding [GO:0019900]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; kinase binding [GO:0019900]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26903630}. Nucleus {ECO:0000269|PubMed:26903630}. Note=Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS. {ECO:0000250|UniProtKB:O70361}.
P56693	reviewed	SOX10_HUMAN	Transcription factor SOX-10	SOX10	Homo sapiens (Human)	466	FUNCTION: Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). {ECO:0000250|UniProtKB:O55170, ECO:0000250|UniProtKB:Q04888, ECO:0000269|PubMed:21965087}.		anatomical structure morphogenesis [GO:0009653]; cell maturation [GO:0048469]; cellular response to progesterone stimulus [GO:0071393]; cellular response to xenobiotic stimulus [GO:0071466]; central nervous system myelination [GO:0022010]; developmental growth [GO:0048589]; digestive tract morphogenesis [GO:0048546]; enteric nervous system development [GO:0048484]; in utero embryonic development [GO:0001701]; lacrimal gland development [GO:0032808]; melanocyte differentiation [GO:0030318]; morphogenesis of a branching epithelium [GO:0061138]; morphogenesis of an epithelium [GO:0002009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; peripheral nervous system development [GO:0007422]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of gliogenesis [GO:0014015]; positive regulation of myelination [GO:0031643]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]	chromatin [GO:0000785]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; cell maturation [GO:0048469]; cellular response to progesterone stimulus [GO:0071393]; cellular response to xenobiotic stimulus [GO:0071466]; central nervous system myelination [GO:0022010]; developmental growth [GO:0048589]; digestive tract morphogenesis [GO:0048546]; enteric nervous system development [GO:0048484]; in utero embryonic development [GO:0001701]; lacrimal gland development [GO:0032808]; melanocyte differentiation [GO:0030318]; morphogenesis of a branching epithelium [GO:0061138]; morphogenesis of an epithelium [GO:0002009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; peripheral nervous system development [GO:0007422]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of gliogenesis [GO:0014015]; positive regulation of myelination [GO:0031643]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12138193}. Nucleus {ECO:0000269|PubMed:12138193}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q04888}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q04888}; Cytoplasmic side {ECO:0000250|UniProtKB:Q04888}.
P56696	reviewed	KCNQ4_HUMAN	Potassium voltage-gated channel subfamily KQT member 4 (KQT-like 4) (Potassium channel subunit alpha KvLQT4) (Voltage-gated potassium channel subunit Kv7.4)	KCNQ4	Homo sapiens (Human)	695	FUNCTION: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.	MISCELLANEOUS: Mutagenesis experiments were carried out by expressing in Xenopus oocytes KCNQ4 mutants either individually (homomultimers) or in combination with wild-type KCNQ4 (mut/wt homomultimers) in a ratio of 1:1, to mimic the situation in a heterozygous DFNA2 patient.	inner ear morphogenesis [GO:0042472]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sensory perception of sound [GO:0007605]	basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	potassium channel activity [GO:0005267]; voltage-gated potassium channel activity [GO:0005249]	basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; potassium channel activity [GO:0005267]; voltage-gated potassium channel activity [GO:0005249]; inner ear morphogenesis [GO:0042472]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells. {ECO:0000250}.
P56703	reviewed	WNT3_HUMAN	Proto-oncogene Wnt-3 (Proto-oncogene Int-4 homolog)	WNT3 INT4	Homo sapiens (Human)	355	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406). {ECO:0000250|UniProtKB:P17553, ECO:0000269|PubMed:14872406, ECO:0000269|PubMed:26902720, ECO:0000305}.		anterior/posterior axis specification [GO:0009948]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [GO:0044338]; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954]; canonical Wnt signaling pathway involved in osteoblast differentiation [GO:0044339]; canonical Wnt signaling pathway involved in stem cell proliferation [GO:1905474]; cell fate commitment [GO:0045165]; cell morphogenesis [GO:0000902]; cellular response to retinoic acid [GO:0071300]; dorsal/ventral axis specification [GO:0009950]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; gamete generation [GO:0007276]; gene expression [GO:0010467]; head morphogenesis [GO:0060323]; limb bud formation [GO:0060174]; mammary gland epithelium development [GO:0061180]; mesoderm formation [GO:0001707]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neuron differentiation [GO:0030182]; positive regulation of collateral sprouting in absence of injury [GO:0048697]; positive regulation of gene expression [GO:0010628]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of neurogenesis [GO:0050767]; Spemann organizer formation at the anterior end of the primitive streak [GO:0060064]; stem cell proliferation [GO:0072089]	endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]	endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; anterior/posterior axis specification [GO:0009948]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [GO:0044338]; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954]; canonical Wnt signaling pathway involved in osteoblast differentiation [GO:0044339]; canonical Wnt signaling pathway involved in stem cell proliferation [GO:1905474]; cell fate commitment [GO:0045165]; cell morphogenesis [GO:0000902]; cellular response to retinoic acid [GO:0071300]; dorsal/ventral axis specification [GO:0009950]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; gamete generation [GO:0007276]; gene expression [GO:0010467]; head morphogenesis [GO:0060323]; limb bud formation [GO:0060174]; mammary gland epithelium development [GO:0061180]; mesoderm formation [GO:0001707]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neuron differentiation [GO:0030182]; positive regulation of collateral sprouting in absence of injury [GO:0048697]; positive regulation of gene expression [GO:0010628]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of neurogenesis [GO:0050767]; Spemann organizer formation at the anterior end of the primitive streak [GO:0060064]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
P56704	reviewed	WNT3A_HUMAN	Protein Wnt-3a	WNT3A	Homo sapiens (Human)	352	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720). {ECO:0000250|UniProtKB:P27467, ECO:0000269|PubMed:20093360, ECO:0000269|PubMed:21244856, ECO:0000269|PubMed:24841207, ECO:0000269|PubMed:26902720, ECO:0000305}.		axis elongation involved in somitogenesis [GO:0090245]; axon guidance [GO:0007411]; B cell proliferation [GO:0042100]; calcium ion transmembrane transport via low voltage-gated calcium channel [GO:0090676]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [GO:0061317]; canonical Wnt signaling pathway involved in heart development [GO:0061316]; cell fate commitment [GO:0045165]; cell population proliferation [GO:0008283]; cell proliferation in forebrain [GO:0021846]; cell proliferation in midbrain [GO:0033278]; cellular response to retinoic acid [GO:0071300]; COP9 signalosome assembly [GO:0010387]; dorsal/ventral neural tube patterning [GO:0021904]; extracellular matrix organization [GO:0030198]; fat cell differentiation [GO:0045444]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; mammary gland development [GO:0030879]; modulation of chemical synaptic transmission [GO:0050804]; myoblast differentiation [GO:0045445]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron projection development [GO:0010977]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; paraxial mesodermal cell fate commitment [GO:0048343]; platelet aggregation [GO:0070527]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [GO:2000081]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of collateral sprouting in absence of injury [GO:0048697]; positive regulation of cytokine production [GO:0001819]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of mesodermal cell fate specification [GO:0048337]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; presynapse assembly [GO:0099054]; protein localization [GO:0008104]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of postsynapse to nucleus signaling pathway [GO:1905539]; regulation of presynapse assembly [GO:1905606]; regulation of synapse organization [GO:0050807]; secondary palate development [GO:0062009]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spinal cord association neuron differentiation [GO:0021527]; synaptic vesicle recycling [GO:0036465]; transcription by RNA polymerase II [GO:0006366]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]	co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]	cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]; co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; axis elongation involved in somitogenesis [GO:0090245]; axon guidance [GO:0007411]; B cell proliferation [GO:0042100]; calcium ion transmembrane transport via low voltage-gated calcium channel [GO:0090676]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [GO:0061317]; canonical Wnt signaling pathway involved in heart development [GO:0061316]; cell fate commitment [GO:0045165]; cell population proliferation [GO:0008283]; cell proliferation in forebrain [GO:0021846]; cell proliferation in midbrain [GO:0033278]; cellular response to retinoic acid [GO:0071300]; COP9 signalosome assembly [GO:0010387]; dorsal/ventral neural tube patterning [GO:0021904]; extracellular matrix organization [GO:0030198]; fat cell differentiation [GO:0045444]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; mammary gland development [GO:0030879]; modulation of chemical synaptic transmission [GO:0050804]; myoblast differentiation [GO:0045445]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron projection development [GO:0010977]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; paraxial mesodermal cell fate commitment [GO:0048343]; platelet aggregation [GO:0070527]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [GO:2000081]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of collateral sprouting in absence of injury [GO:0048697]; positive regulation of cytokine production [GO:0001819]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of mesodermal cell fate specification [GO:0048337]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; presynapse assembly [GO:0099054]; protein localization [GO:0008104]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of postsynapse to nucleus signaling pathway [GO:1905539]; regulation of presynapse assembly [GO:1905606]; regulation of synapse organization [GO:0050807]; secondary palate development [GO:0062009]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spinal cord association neuron differentiation [GO:0021527]; synaptic vesicle recycling [GO:0036465]; transcription by RNA polymerase II [GO:0006366]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P27467}. Secreted {ECO:0000269|PubMed:24841207, ECO:0000269|PubMed:26902720}.
P56705	reviewed	WNT4_HUMAN	Protein Wnt-4	WNT4 UNQ426/PRO864	Homo sapiens (Human)	351	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung (PubMed:15317892, PubMed:16959810, PubMed:18179883, PubMed:18182450). Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity). {ECO:0000250|UniProtKB:P22724, ECO:0000269|PubMed:15317892, ECO:0000269|PubMed:16959810, ECO:0000269|PubMed:18179883, ECO:0000269|PubMed:18182450, ECO:0000305}.		adrenal gland development [GO:0030325]; apoptotic signaling pathway [GO:0097190]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic epithelial tube formation [GO:0001838]; epithelial to mesenchymal transition [GO:0001837]; female gonad development [GO:0008585]; female sex determination [GO:0030237]; fibroblast growth factor receptor signaling pathway [GO:0008543]; hormone metabolic process [GO:0042445]; immature T cell proliferation in thymus [GO:0033080]; kidney development [GO:0001822]; liver development [GO:0001889]; male gonad development [GO:0008584]; mammary gland epithelium development [GO:0061180]; meiotic nuclear division [GO:0140013]; mesenchymal to epithelial transition [GO:0060231]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric nephron morphogenesis [GO:0072273]; metanephric tubule formation [GO:0072174]; negative regulation of androgen biosynthetic process [GO:2000180]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression [GO:0010629]; negative regulation of male gonad development [GO:2000019]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of testicular blood vessel morphogenesis [GO:0061369]; negative regulation of testosterone biosynthetic process [GO:2000225]; negative regulation of wound healing [GO:0061045]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway via MAPK cascade [GO:0038030]; oocyte development [GO:0048599]; paramesonephric duct development [GO:0061205]; pericyte cell differentiation [GO:1904238]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of bone mineralization [GO:0030501]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cortisol biosynthetic process [GO:2000066]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell-cell adhesion [GO:0022407]; renal vesicle formation [GO:0072033]; renal vesicle induction [GO:0072034]; Sertoli cell differentiation [GO:0060008]; smooth muscle cell differentiation [GO:0051145]; somatotropin secreting cell differentiation [GO:0060126]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; transcription corepressor activity [GO:0003714]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; transcription corepressor activity [GO:0003714]; adrenal gland development [GO:0030325]; apoptotic signaling pathway [GO:0097190]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic epithelial tube formation [GO:0001838]; epithelial to mesenchymal transition [GO:0001837]; female gonad development [GO:0008585]; female sex determination [GO:0030237]; fibroblast growth factor receptor signaling pathway [GO:0008543]; hormone metabolic process [GO:0042445]; immature T cell proliferation in thymus [GO:0033080]; kidney development [GO:0001822]; liver development [GO:0001889]; male gonad development [GO:0008584]; mammary gland epithelium development [GO:0061180]; meiotic nuclear division [GO:0140013]; mesenchymal to epithelial transition [GO:0060231]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric nephron morphogenesis [GO:0072273]; metanephric tubule formation [GO:0072174]; negative regulation of androgen biosynthetic process [GO:2000180]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression [GO:0010629]; negative regulation of male gonad development [GO:2000019]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of testicular blood vessel morphogenesis [GO:0061369]; negative regulation of testosterone biosynthetic process [GO:2000225]; negative regulation of wound healing [GO:0061045]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway via MAPK cascade [GO:0038030]; oocyte development [GO:0048599]; paramesonephric duct development [GO:0061205]; pericyte cell differentiation [GO:1904238]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of bone mineralization [GO:0030501]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cortisol biosynthetic process [GO:2000066]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell-cell adhesion [GO:0022407]; renal vesicle formation [GO:0072033]; renal vesicle induction [GO:0072034]; Sertoli cell differentiation [GO:0060008]; smooth muscle cell differentiation [GO:0051145]; somatotropin secreting cell differentiation [GO:0060126]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
P56706	reviewed	WNT7B_HUMAN	Protein Wnt-7b	WNT7B	Homo sapiens (Human)	349	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). {ECO:0000250|UniProtKB:P28047, ECO:0000269|PubMed:30026314}.		canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; central nervous system vasculogenesis [GO:0022009]; chorio-allantoic fusion [GO:0060710]; developmental growth involved in morphogenesis [GO:0060560]; embryonic organ development [GO:0048568]; embryonic placenta morphogenesis [GO:0060669]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; fibroblast proliferation [GO:0048144]; forebrain regionalization [GO:0021871]; homeostatic process [GO:0042592]; in utero embryonic development [GO:0001701]; inner medullary collecting duct development [GO:0072061]; intracellular oxygen homeostasis [GO:0032364]; lens fiber cell development [GO:0070307]; lobar bronchus development [GO:0060482]; lung development [GO:0030324]; lung epithelium development [GO:0060428]; lung morphogenesis [GO:0060425]; mammary gland epithelium development [GO:0061180]; metanephric collecting duct development [GO:0072205]; metanephric epithelium development [GO:0072207]; metanephric loop of Henle development [GO:0072236]; metanephros morphogenesis [GO:0003338]; neuron differentiation [GO:0030182]; neuron projection morphogenesis [GO:0048812]; outer medullary collecting duct development [GO:0072060]; positive regulation of JNK cascade [GO:0046330]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of cell projection size [GO:0032536]; renal inner medulla development [GO:0072053]; renal outer medulla development [GO:0072054]; response to glucocorticoid [GO:0051384]; stem cell proliferation [GO:0072089]; synapse organization [GO:0050808]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]	endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]	endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; central nervous system vasculogenesis [GO:0022009]; chorio-allantoic fusion [GO:0060710]; developmental growth involved in morphogenesis [GO:0060560]; embryonic organ development [GO:0048568]; embryonic placenta morphogenesis [GO:0060669]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; fibroblast proliferation [GO:0048144]; forebrain regionalization [GO:0021871]; homeostatic process [GO:0042592]; in utero embryonic development [GO:0001701]; inner medullary collecting duct development [GO:0072061]; intracellular oxygen homeostasis [GO:0032364]; lens fiber cell development [GO:0070307]; lobar bronchus development [GO:0060482]; lung development [GO:0030324]; lung epithelium development [GO:0060428]; lung morphogenesis [GO:0060425]; mammary gland epithelium development [GO:0061180]; metanephric collecting duct development [GO:0072205]; metanephric epithelium development [GO:0072207]; metanephric loop of Henle development [GO:0072236]; metanephros morphogenesis [GO:0003338]; neuron differentiation [GO:0030182]; neuron projection morphogenesis [GO:0048812]; outer medullary collecting duct development [GO:0072060]; positive regulation of JNK cascade [GO:0046330]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of cell projection size [GO:0032536]; renal inner medulla development [GO:0072053]; renal outer medulla development [GO:0072054]; response to glucocorticoid [GO:0051384]; stem cell proliferation [GO:0072089]; synapse organization [GO:0050808]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
P56715	reviewed	RP1_HUMAN	Oxygen-regulated protein 1 (Retinitis pigmentosa 1 protein) (Retinitis pigmentosa RP1 protein)	RP1 ORP1	Homo sapiens (Human)	2156	FUNCTION: Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme (By similarity). {ECO:0000250}.		axoneme assembly [GO:0035082]; cellular response to light stimulus [GO:0071482]; intracellular signal transduction [GO:0035556]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; phototransduction, visible light [GO:0007603]; positive regulation of non-motile cilium assembly [GO:1902857]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601]	axoneme [GO:0005930]; ciliary tip [GO:0097542]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	microtubule binding [GO:0008017]	axoneme [GO:0005930]; ciliary tip [GO:0097542]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; microtubule binding [GO:0008017]; axoneme assembly [GO:0035082]; cellular response to light stimulus [GO:0071482]; intracellular signal transduction [GO:0035556]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; phototransduction, visible light [GO:0007603]; positive regulation of non-motile cilium assembly [GO:1902857]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:11773008}. Note=Specifically localized in the connecting cilia of rod and cone photoreceptors.
P56730	reviewed	NETR_HUMAN	Neurotrypsin (EC 3.4.21.-) (Leydin) (Motopsin) (Serine protease 12)	PRSS12	Homo sapiens (Human)	875	FUNCTION: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. {ECO:0000250}.		exocytosis [GO:0006887]; zymogen activation [GO:0031638]	axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; terminal bouton [GO:0043195]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; terminal bouton [GO:0043195]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; exocytosis [GO:0006887]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Secreted.
P56746	reviewed	CLD15_HUMAN	Claudin-15	CLDN15	Homo sapiens (Human)	228	FUNCTION: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake. {ECO:0000269|PubMed:12055082, ECO:0000269|PubMed:13129853}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; monoatomic ion transport [GO:0006811]	bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; monoatomic ion transport [GO:0006811]	SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy.
P56747	reviewed	CLD6_HUMAN	Claudin-6 (Skullin)	CLDN6 UNQ757/PRO1488	Homo sapiens (Human)	220	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. {ECO:0000269|PubMed:17804490, ECO:0000269|PubMed:20375010}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; virus receptor activity [GO:0001618]	apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; virus receptor activity [GO:0001618]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Z262}. Cell membrane {ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}.
P56748	reviewed	CLD8_HUMAN	Claudin-8	CLDN8 UNQ779/PRO1573	Homo sapiens (Human)	225	FUNCTION: Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250|UniProtKB:Q9Z260}.	MISCELLANEOUS: A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells. {ECO:0000305|PubMed:22042635}.	bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:17287494}. Cell membrane {ECO:0000250|UniProtKB:Q9Z260}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells. {ECO:0000269|PubMed:17287494}.
P56750	reviewed	CLD17_HUMAN	Claudin-17	CLDN17 UNQ758/PRO1489	Homo sapiens (Human)	224	FUNCTION: Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability. {ECO:0000269|PubMed:22402829}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	bicellular tight junction [GO:0005923]; chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:22402829}. Cell membrane {ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}.
P56817	reviewed	BACE1_HUMAN	Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)	BACE1 BACE KIAA1149	Homo sapiens (Human)	501	FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, PubMed:20354142). Cleaves CHL1 (By similarity). {ECO:0000250|UniProtKB:P56818, ECO:0000269|PubMed:10656250, ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:20354142}.		amyloid fibril formation [GO:1990000]; amyloid precursor protein catabolic process [GO:0042987]; amyloid-beta formation [GO:0034205]; amyloid-beta metabolic process [GO:0050435]; cellular response to amyloid-beta [GO:1904646]; cellular response to copper ion [GO:0071280]; cellular response to manganese ion [GO:0071287]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; membrane protein ectodomain proteolysis [GO:0006509]; positive regulation of neuron apoptotic process [GO:0043525]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to lead ion [GO:0010288]; signaling receptor ligand precursor processing [GO:0140448]	axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle lumen [GO:0070931]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]	amyloid-beta binding [GO:0001540]; aspartic-type endopeptidase activity [GO:0004190]; beta-aspartyl-peptidase activity [GO:0008798]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; peptidase activity [GO:0008233]	axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle lumen [GO:0070931]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; amyloid-beta binding [GO:0001540]; aspartic-type endopeptidase activity [GO:0004190]; beta-aspartyl-peptidase activity [GO:0008798]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; peptidase activity [GO:0008233]; amyloid fibril formation [GO:1990000]; amyloid precursor protein catabolic process [GO:0042987]; amyloid-beta formation [GO:0034205]; amyloid-beta metabolic process [GO:0050435]; cellular response to amyloid-beta [GO:1904646]; cellular response to copper ion [GO:0071280]; cellular response to manganese ion [GO:0071287]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; membrane protein ectodomain proteolysis [GO:0006509]; positive regulation of neuron apoptotic process [GO:0043525]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to lead ion [GO:0010288]; signaling receptor ligand precursor processing [GO:0140448]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11466313}; Single-pass type I membrane protein {ECO:0000305|PubMed:11466313}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:11466313, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:17425515, ECO:0000269|PubMed:20354142, ECO:0000269|PubMed:23109336}. Endoplasmic reticulum {ECO:0000269|PubMed:11466313, ECO:0000269|PubMed:17425515}. Endosome {ECO:0000269|PubMed:11466313, ECO:0000269|PubMed:15886016}. Cell surface {ECO:0000269|PubMed:11466313, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:17425515, ECO:0000269|PubMed:23109336}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:11466313, ECO:0000269|PubMed:15886016}; Single-pass type I membrane protein {ECO:0000305|PubMed:11466313}. Membrane raft {ECO:0000250|UniProtKB:P56818}. Lysosome {ECO:0000269|PubMed:16033761, ECO:0000269|PubMed:23109336, ECO:0000269|PubMed:27084579, ECO:0000269|PubMed:27302062}. Late endosome {ECO:0000269|PubMed:16033761, ECO:0000269|PubMed:23109336, ECO:0000269|PubMed:27084579, ECO:0000269|PubMed:27302062}. Early endosome {ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:23109336, ECO:0000269|PubMed:27084579, ECO:0000269|PubMed:27302062}. Recycling endosome {ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:27084579, ECO:0000269|PubMed:27302062}. Cell projection, axon {ECO:0000250|UniProtKB:P56818}. Cell projection, dendrite {ECO:0000250|UniProtKB:P56818}. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (PubMed:17425515, PubMed:11466313). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (By similarity). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (PubMed:15886016). {ECO:0000250|UniProtKB:P56818, ECO:0000269|PubMed:11466313, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:17425515}.
P56851	reviewed	EP3B_HUMAN	Epididymal secretory protein E3-beta (Human epididymis-specific protein 3-beta) (HE3-beta)	EDDM3B FAM12B HE3B UNQ6412/PRO21187	Homo sapiens (Human)	147	FUNCTION: Possible function in sperm maturation.			extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P56856	reviewed	CLD18_HUMAN	Claudin-18	CLDN18 UNQ778/PRO1572	Homo sapiens (Human)	261	FUNCTION: Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (By similarity). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity). {ECO:0000250|UniProtKB:P56857}.; FUNCTION: [Isoform A1]: Involved in the maintenance of homeostasis of the alveolar microenvironment via regulation of pH and subsequent T-cell activation in the alveolar space, is therefore indirectly involved in limiting C. neoformans infection. {ECO:0000250|UniProtKB:P56857}.; FUNCTION: [Isoform A2]: Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification. {ECO:0000250|UniProtKB:P56857}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; digestive tract development [GO:0048565]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast development [GO:2001205]; negative regulation of protein localization to nucleus [GO:1900181]; protein localization to nucleus [GO:0034504]; response to ethanol [GO:0045471]; TNFSF11-mediated signaling pathway [GO:0071847]	bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; digestive tract development [GO:0048565]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast development [GO:2001205]; negative regulation of protein localization to nucleus [GO:1900181]; protein localization to nucleus [GO:0034504]; response to ethanol [GO:0045471]; TNFSF11-mediated signaling pathway [GO:0071847]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. Cell membrane {ECO:0000250|UniProtKB:P56857}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to tight junctions in epithelial cells. {ECO:0000250|UniProtKB:P56857}.; SUBCELLULAR LOCATION: [Isoform A1]: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}.; SUBCELLULAR LOCATION: [Isoform A2]: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. Lateral cell membrane {ECO:0000250|UniProtKB:P56857}.
P56880	reviewed	CLD20_HUMAN	Claudin-20	CLDN20	Homo sapiens (Human)	219	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; tight junction [GO:0070160]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; tight junction [GO:0070160]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
P56915	reviewed	GSC_HUMAN	Homeobox protein goosecoid	GSC	Homo sapiens (Human)	257	FUNCTION: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. {ECO:0000250, ECO:0000269|PubMed:24290375}.		dorsal/ventral neural tube patterning [GO:0021904]; embryonic skeletal system morphogenesis [GO:0048704]; forebrain development [GO:0030900]; gastrulation [GO:0007369]; middle ear morphogenesis [GO:0042474]; muscle organ morphogenesis [GO:0048644]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell fate specification [GO:0014036]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction involved in regulation of gene expression [GO:0023019]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; dorsal/ventral neural tube patterning [GO:0021904]; embryonic skeletal system morphogenesis [GO:0048704]; forebrain development [GO:0030900]; gastrulation [GO:0007369]; middle ear morphogenesis [GO:0042474]; muscle organ morphogenesis [GO:0048644]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell fate specification [GO:0014036]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction involved in regulation of gene expression [GO:0023019]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus.
P56937	reviewed	DHB7_HUMAN	3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 37C member 1)	HSD17B7 17HSD7 SDR37C1 UNQ2563/PRO6243	Homo sapiens (Human)	341	FUNCTION: Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:20659585, PubMed:19772289, PubMed:11165030). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol (PubMed:12574203, PubMed:12732193, PubMed:19772289). Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation (PubMed:12574203, PubMed:12732193). Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:12829805, PubMed:20659585, PubMed:11165030). {ECO:0000269|PubMed:11165030, ECO:0000269|PubMed:12574203, ECO:0000269|PubMed:12732193, ECO:0000269|PubMed:12829805, ECO:0000269|PubMed:19772289, ECO:0000269|PubMed:20659585}.; FUNCTION: [Isoform 3]: Does not have enzymatic activities toward E1 and DHT. {ECO:0000269|PubMed:12732193}.		androgen metabolic process [GO:0008209]; cholesterol biosynthetic process [GO:0006695]; estrogen biosynthetic process [GO:0006703]	endoplasmic reticulum membrane [GO:0005789]	3-keto sterol reductase activity [GO:0000253]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]	endoplasmic reticulum membrane [GO:0005789]; 3-keto sterol reductase activity [GO:0000253]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; androgen metabolic process [GO:0008209]; cholesterol biosynthetic process [GO:0006695]; estrogen biosynthetic process [GO:0006703]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12829805}; Single-pass membrane protein {ECO:0000255}.
P56945	reviewed	BCAR1_HUMAN	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)	BCAR1 CAS CASS1 CRKAS	Homo sapiens (Human)	870	FUNCTION: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12832404, PubMed:12432078). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}.		actin filament organization [GO:0007015]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell receptor signaling pathway [GO:0050853]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell division [GO:0051301]; cell migration [GO:0016477]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; insulin receptor signaling pathway [GO:0008286]; integrin-mediated signaling pathway [GO:0007229]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell migration [GO:0010595]; regulation of apoptotic process [GO:0042981]; regulation of cell growth [GO:0001558]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; ruffle [GO:0001726]	protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; ruffle [GO:0001726]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; actin filament organization [GO:0007015]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell receptor signaling pathway [GO:0050853]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell division [GO:0051301]; cell migration [GO:0016477]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; insulin receptor signaling pathway [GO:0008286]; integrin-mediated signaling pathway [GO:0007229]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell migration [GO:0010595]; regulation of apoptotic process [GO:0042981]; regulation of cell growth [GO:0001558]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:12832404}. Cytoplasm {ECO:0000269|PubMed:12832404}. Cell projection, axon {ECO:0000250|UniProtKB:Q61140}. Note=Unphosphorylated form localizes in the cytoplasm (By similarity). Localizes to focal adhesion sites following integrin engagement (By similarity). {ECO:0000250|UniProtKB:Q61140}.
P56962	reviewed	STX17_HUMAN	Syntaxin-17	STX17	Homo sapiens (Human)	302	FUNCTION: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion (PubMed:23217709, PubMed:25686604, PubMed:28306502). STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604, PubMed:28306502, PubMed:28504273). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). {ECO:0000269|PubMed:21545355, ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686604, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:28504273}.		autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein localization to phagophore assembly site [GO:0034497]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; SNARE complex [GO:0031201]	protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; SNARE complex [GO:0031201]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein localization to phagophore assembly site [GO:0034497]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23006999}; Multi-pass membrane protein {ECO:0000255}. Smooth endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:23006999}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686604, ECO:0000269|PubMed:26416964, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:29420192}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z158}. Mitochondrion membrane {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:28504273}; Multi-pass membrane protein {ECO:0000255}. Note=Has a hairpin-like insertion into membranes. Localizes to the completed autophagosome membrane upon cell starvation (PubMed:23217709). {ECO:0000269|PubMed:23217709}.
P56975	reviewed	NRG3_HUMAN	Pro-neuregulin-3, membrane-bound isoform (Pro-NRG3) [Cleaved into: Neuregulin-3 (NRG-3)]	NRG3	Homo sapiens (Human)	720	FUNCTION: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. {ECO:0000269|PubMed:16478787, ECO:0000269|PubMed:9275162}.		animal organ development [GO:0048513]; chemorepulsion involved in interneuron migration from the subpallium to the cortex [GO:0021842]; ERBB4 signaling pathway [GO:0038130]; ERBB4-ERBB4 signaling pathway [GO:0038138]; intracellular signal transduction [GO:0035556]; mammary placode formation [GO:0060596]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of neuron migration [GO:2001223]; pattern specification process [GO:0007389]; regulation of cell growth [GO:0001558]; synapse assembly [GO:0007416]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]	chemorepellent activity [GO:0045499]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; chemorepellent activity [GO:0045499]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; animal organ development [GO:0048513]; chemorepulsion involved in interneuron migration from the subpallium to the cortex [GO:0021842]; ERBB4 signaling pathway [GO:0038130]; ERBB4-ERBB4 signaling pathway [GO:0038138]; intracellular signal transduction [GO:0035556]; mammary placode formation [GO:0060596]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of neuron migration [GO:2001223]; pattern specification process [GO:0007389]; regulation of cell growth [GO:0001558]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: [Pro-neuregulin-3, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; SUBCELLULAR LOCATION: [Neuregulin-3]: Secreted {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.
P57052	reviewed	RBM11_HUMAN	Splicing regulator RBM11 (RNA-binding motif protein 11)	RBM11	Homo sapiens (Human)	281	FUNCTION: Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1. {ECO:0000269|PubMed:21984414}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell differentiation [GO:0030154]; cellular response to oxidative stress [GO:0034599]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	poly(U) RNA binding [GO:0008266]; protein homodimerization activity [GO:0042803]; single-stranded RNA binding [GO:0003727]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; poly(U) RNA binding [GO:0008266]; protein homodimerization activity [GO:0042803]; single-stranded RNA binding [GO:0003727]; cell differentiation [GO:0030154]; cellular response to oxidative stress [GO:0034599]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:21984414}. Nucleus speckle {ECO:0000269|PubMed:21984414}. Note=Enriched in SRSF2-containing splicing speckles; shuttles between nucleoplasm and speckles.
P57053	reviewed	H2BFS_HUMAN	Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s)	H2BC12L H2BFS H2BS1	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; substantia nigra development [GO:0021762]	cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P57054	reviewed	PIGP_HUMAN	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (Down syndrome critical region protein 5) (Down syndrome critical region protein C) (Phosphatidylinositol-glycan biosynthesis class P protein) (PIG-P)	PIGP DCRC DSCR5 DSCRC NPD010	Homo sapiens (Human)	158	FUNCTION: Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. {ECO:0000269|PubMed:10944123, ECO:0000269|PubMed:16162815, ECO:0000269|PubMed:28334793}.		GPI anchor biosynthetic process [GO:0006506]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]	phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176]; GPI anchor biosynthetic process [GO:0006506]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P57055	reviewed	DSCR6_HUMAN	Protein ripply3 (Down syndrome critical region protein 6)	RIPPLY3 DSCR6	Homo sapiens (Human)	190	FUNCTION: Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity). {ECO:0000250}.		cell population proliferation [GO:0008283]; embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pharyngeal system development [GO:0060037]	nucleus [GO:0005634]		nucleus [GO:0005634]; cell population proliferation [GO:0008283]; embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pharyngeal system development [GO:0060037]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P57057	reviewed	G6PT2_HUMAN	Glucose-6-phosphate exchanger SLC37A1 (Glycerol-3-phosphate permease) (G-3-P permease) (Solute carrier family 37 member 1)	SLC37A1 G3PP	Homo sapiens (Human)	533	FUNCTION: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. {ECO:0000269|PubMed:21949678}.		carbohydrate transport [GO:0008643]; glucose-6-phosphate transport [GO:0015760]; phosphate ion transmembrane transport [GO:0035435]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	glucose 6-phosphate:inorganic phosphate antiporter activity [GO:0061513]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; glucose 6-phosphate:inorganic phosphate antiporter activity [GO:0061513]; carbohydrate transport [GO:0008643]; glucose-6-phosphate transport [GO:0015760]; phosphate ion transmembrane transport [GO:0035435]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21949678}; Multi-pass membrane protein {ECO:0000255}.
P57059	reviewed	SIK1_HUMAN	Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)	SIK1 SIK SNF1LK	Homo sapiens (Human)	783	FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). {ECO:0000250|UniProtKB:Q60670, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:19622832, ECO:0000269|PubMed:29211348}.		anoikis [GO:0043276]; cardiac muscle cell differentiation [GO:0055007]; cell cycle [GO:0007049]; entrainment of circadian clock by photoperiod [GO:0043153]; intracellular signal transduction [GO:0035556]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of triglyceride biosynthetic process [GO:0010868]; positive regulation of anoikis [GO:2000210]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell differentiation [GO:0045595]; regulation of mitotic cell cycle [GO:0007346]; regulation of myotube differentiation [GO:0010830]; regulation of sodium ion transport [GO:0002028]; rhythmic process [GO:0048511]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; cAMP response element binding protein binding [GO:0008140]; histone deacetylase binding [GO:0042826]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; cAMP response element binding protein binding [GO:0008140]; histone deacetylase binding [GO:0042826]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; anoikis [GO:0043276]; cardiac muscle cell differentiation [GO:0055007]; cell cycle [GO:0007049]; entrainment of circadian clock by photoperiod [GO:0043153]; intracellular signal transduction [GO:0035556]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of triglyceride biosynthetic process [GO:0010868]; positive regulation of anoikis [GO:2000210]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell differentiation [GO:0045595]; regulation of mitotic cell cycle [GO:0007346]; regulation of myotube differentiation [GO:0010830]; regulation of sodium ion transport [GO:0002028]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:29211348}. Nucleus {ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:29211348}. Note=Locates to cytoplasm when inactive following cAMP-induced phosphorylation, probably by PKA (PubMed:29211348).
P57071	reviewed	PRD15_HUMAN	PR domain zinc finger protein 15 (EC 2.1.1.-) (PR domain-containing protein 15) (Zinc finger protein 298)	PRDM15 C21orf83 ZNF298	Homo sapiens (Human)	1507	FUNCTION: Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Also plays a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264). {ECO:0000250|UniProtKB:E9Q8T2, ECO:0000269|PubMed:28740264}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	methylation [GO:0032259]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stem cell division [GO:2000035]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; methylation [GO:0032259]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stem cell division [GO:2000035]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15904895}.
P57073	reviewed	SOX8_HUMAN	Transcription factor SOX-8	SOX8	Homo sapiens (Human)	446	FUNCTION: Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). {ECO:0000250|UniProtKB:Q04886}.		adipose tissue development [GO:0060612]; astrocyte fate commitment [GO:0060018]; cell fate commitment [GO:0045165]; cell maturation [GO:0048469]; enteric nervous system development [GO:0048484]; fat cell differentiation [GO:0045444]; in utero embryonic development [GO:0001701]; male gonad development [GO:0008584]; metanephric nephron tubule formation [GO:0072289]; morphogenesis of a branching epithelium [GO:0061138]; morphogenesis of an epithelium [GO:0002009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; neural crest cell migration [GO:0001755]; oligodendrocyte differentiation [GO:0048709]; osteoblast differentiation [GO:0001649]; peripheral nervous system development [GO:0007422]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of gliogenesis [GO:0014015]; positive regulation of kidney development [GO:0090184]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of hormone levels [GO:0010817]; renal vesicle induction [GO:0072034]; retina development in camera-type eye [GO:0060041]; retinal rod cell differentiation [GO:0060221]; Sertoli cell development [GO:0060009]; signal transduction [GO:0007165]; skeletal muscle cell differentiation [GO:0035914]; spermatogenesis [GO:0007283]; ureter morphogenesis [GO:0072197]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; adipose tissue development [GO:0060612]; astrocyte fate commitment [GO:0060018]; cell fate commitment [GO:0045165]; cell maturation [GO:0048469]; enteric nervous system development [GO:0048484]; fat cell differentiation [GO:0045444]; in utero embryonic development [GO:0001701]; male gonad development [GO:0008584]; metanephric nephron tubule formation [GO:0072289]; morphogenesis of a branching epithelium [GO:0061138]; morphogenesis of an epithelium [GO:0002009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; neural crest cell migration [GO:0001755]; oligodendrocyte differentiation [GO:0048709]; osteoblast differentiation [GO:0001649]; peripheral nervous system development [GO:0007422]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of gliogenesis [GO:0014015]; positive regulation of kidney development [GO:0090184]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of hormone levels [GO:0010817]; renal vesicle induction [GO:0072034]; retina development in camera-type eye [GO:0060041]; retinal rod cell differentiation [GO:0060221]; Sertoli cell development [GO:0060009]; signal transduction [GO:0007165]; skeletal muscle cell differentiation [GO:0035914]; spermatogenesis [GO:0007283]; ureter morphogenesis [GO:0072197]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
P57075	reviewed	UBS3A_HUMAN	Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)	UBASH3A STS2	Homo sapiens (Human)	661	FUNCTION: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17382318, ECO:0000269|PubMed:18189269}.		negative regulation of T cell receptor signaling pathway [GO:0050860]; regulation of cytokine production [GO:0001817]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; negative regulation of T cell receptor signaling pathway [GO:0050860]; regulation of cytokine production [GO:0001817]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
P57076	reviewed	CF298_HUMAN	Cilia- and flagella-associated protein 298 (Protein kurly homolog)	CFAP298 C21orf48 C21orf59	Homo sapiens (Human)	290	FUNCTION: Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744). Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity). {ECO:0000250|UniProtKB:Q6DRC3, ECO:0000269|PubMed:24094744}.		cilium assembly [GO:0060271]; regulation of cilium movement [GO:0003352]	cilium [GO:0005929]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]		cilium [GO:0005929]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; cilium assembly [GO:0060271]; regulation of cilium movement [GO:0003352]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29601588}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A0A1L8HCK2}. Note=Partially colocalized with SASS6 in cytoplasmic puncta, suggesting a centrosomal localization. {ECO:0000250|UniProtKB:Q5U3Z0}.
P57078	reviewed	RIPK4_HUMAN	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)	RIPK4 ANKRD3 DIK	Homo sapiens (Human)	832	FUNCTION: Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. {ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}.		morphogenesis of an epithelium [GO:0002009]; phosphorylation [GO:0016310]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]	cytoplasm [GO:0005737]; membrane [GO:0016020]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; membrane [GO:0016020]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; morphogenesis of an epithelium [GO:0002009]; phosphorylation [GO:0016310]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]	SUBCELLULAR LOCATION: Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
P57081	reviewed	WDR4_HUMAN	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (Protein Wuho homolog) (hWH) (WD repeat-containing protein 4)	WDR4	Homo sapiens (Human)	412	FUNCTION: Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083, PubMed:36599982, PubMed:36599985, PubMed:37369656). In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding (PubMed:36599982, PubMed:36599985, PubMed:37369656). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:12403464, PubMed:34352207, PubMed:34352206, PubMed:36599982, PubMed:36599985, PubMed:37369656). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (PubMed:36599982, PubMed:36599985). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084, PubMed:37379838). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069). {ECO:0000269|PubMed:12403464, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:31031083, ECO:0000269|PubMed:31031084, ECO:0000269|PubMed:34352206, ECO:0000269|PubMed:34352207, ECO:0000269|PubMed:36599982, ECO:0000269|PubMed:36599985, ECO:0000269|PubMed:37369656, ECO:0000269|PubMed:37379838}.	MISCELLANEOUS: In the context of cancer, overexpression of the METTL1-WDR4 methyltransferase complex promotes cancer progression by driving oncogenic transformation (PubMed:34352207, PubMed:34352206, PubMed:34371184). The METTL1-WDR4 methyltransferase complex drives oncogenesis by mediating the formation of N(7)-methylguanine at position 46 (m7G46) in some tRNAs, in particular Arg-TCT-4-1 (TRR-TCT4-1), leading to increased translation of mRNAs, including cell cycle regulators that are enriched in the corresponding AGA codon (PubMed:34352207, PubMed:34352206, PubMed:34371184). {ECO:0000269|PubMed:34352206, ECO:0000269|PubMed:34352207, ECO:0000269|PubMed:34371184}.	DNA damage response [GO:0006974]; tRNA (guanine-N7)-methylation [GO:0106004]; tRNA modification [GO:0006400]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m7G46) methyltransferase complex [GO:0106143]; tRNA methyltransferase complex [GO:0043527]	enzyme activator activity [GO:0008047]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m7G46) methyltransferase complex [GO:0106143]; tRNA methyltransferase complex [GO:0043527]; enzyme activator activity [GO:0008047]; DNA damage response [GO:0006974]; tRNA (guanine-N7)-methylation [GO:0106004]; tRNA modification [GO:0006400]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15861136, ECO:0000269|PubMed:26751069}. Chromosome {ECO:0000269|PubMed:26751069}. Note=Localizes at the site of nascent DNA synthesis. {ECO:0000269|PubMed:26751069}.
P57082	reviewed	TBX4_HUMAN	T-box transcription factor TBX4 (T-box protein 4)	TBX4	Homo sapiens (Human)	545	FUNCTION: Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs. {ECO:0000269|PubMed:31761294}.		angiogenesis [GO:0001525]; cell fate specification [GO:0001708]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic lung development [GO:1990401]; limb morphogenesis [GO:0035108]; lung development [GO:0030324]; morphogenesis of an epithelium [GO:0002009]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system morphogenesis [GO:0048705]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; angiogenesis [GO:0001525]; cell fate specification [GO:0001708]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic lung development [GO:1990401]; limb morphogenesis [GO:0035108]; lung development [GO:0030324]; morphogenesis of an epithelium [GO:0002009]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system morphogenesis [GO:0048705]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
P57086	reviewed	SCND1_HUMAN	SCAN domain-containing protein 1	SCAND1 SDP1	Homo sapiens (Human)	179	FUNCTION: May regulate transcriptional activity.		positive regulation of DNA-templated transcription [GO:0045893]	nucleus [GO:0005634]		nucleus [GO:0005634]; positive regulation of DNA-templated transcription [GO:0045893]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
P57087	reviewed	JAM2_HUMAN	Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322)	JAM2 C21orf43 VEJAM UNQ219/PRO245	Homo sapiens (Human)	298	FUNCTION: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:11590146, PubMed:11823489, PubMed:24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:12239159). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:12070135). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (By similarity). {ECO:0000250|UniProtKB:A0A0R4IGV4, ECO:0000250|UniProtKB:Q9JI59, ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:11823489, ECO:0000269|PubMed:12070135, ECO:0000269|PubMed:12239159, ECO:0000269|PubMed:24357068}.		cell-cell adhesion [GO:0098609]; cellular extravasation [GO:0045123]; hematopoietic stem cell migration to bone marrow [GO:0097241]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; lymphocyte aggregation [GO:0071593]; maintenance of blood-brain barrier [GO:0035633]; myoblast fusion [GO:0007520]; negative regulation of myelination [GO:0031642]; positive regulation of lymphocyte migration [GO:2000403]; spermatid development [GO:0007286]	bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; cell-cell contact zone [GO:0044291]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]; somatodendritic compartment [GO:0036477]; tight junction [GO:0070160]	integrin binding [GO:0005178]	bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; cell-cell contact zone [GO:0044291]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]; somatodendritic compartment [GO:0036477]; tight junction [GO:0070160]; integrin binding [GO:0005178]; cell-cell adhesion [GO:0098609]; cellular extravasation [GO:0045123]; hematopoietic stem cell migration to bone marrow [GO:0097241]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; lymphocyte aggregation [GO:0071593]; maintenance of blood-brain barrier [GO:0035633]; myoblast fusion [GO:0007520]; negative regulation of myelination [GO:0031642]; positive regulation of lymphocyte migration [GO:2000403]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10779521, ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:31851307}; Single-pass type I membrane protein {ECO:0000269|PubMed:10779521, ECO:0000269|PubMed:11590146}. Cell junction {ECO:0000269|PubMed:10779521, ECO:0000269|PubMed:10945976}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9JI59}. Note=Localized at tight junctions of both epithelial and endothelial cells (By similarity). Specifically localized within the somatodendritic compartment of neurons and excluded from the axon (By similarity). {ECO:0000250|UniProtKB:Q9JI59}.
P57088	reviewed	TMM33_HUMAN	Transmembrane protein 33 (Protein DB83) (SHINC-3)	TMEM33 DB83	Homo sapiens (Human)	247	FUNCTION: Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696). Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis (PubMed:30760708). Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (PubMed:34487377). {ECO:0000250|UniProtKB:Q9CR67, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26268696, ECO:0000269|PubMed:30760708, ECO:0000269|PubMed:32614325, ECO:0000269|PubMed:34487377}.		endoplasmic reticulum tubular network organization [GO:0071786]; innate immune response [GO:0045087]; membrane organization [GO:0061024]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; regulation of endoplasmic reticulum tubular network organization [GO:1903371]; response to endoplasmic reticulum stress [GO:0034976]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; melanosome [GO:0042470]; nuclear envelope [GO:0005635]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; melanosome [GO:0042470]; nuclear envelope [GO:0005635]; endoplasmic reticulum tubular network organization [GO:0071786]; innate immune response [GO:0045087]; membrane organization [GO:0061024]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; regulation of endoplasmic reticulum tubular network organization [GO:1903371]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26268696}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus envelope {ECO:0000269|PubMed:25612671}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Co-localizes with RTN4 at the ER sheets. {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:25612671}.
P57103	reviewed	NAC3_HUMAN	Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3)	SLC8A3 NCX3	Homo sapiens (Human)	927	FUNCTION: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity). {ECO:0000250|UniProtKB:S4R2P9, ECO:0000269|PubMed:21959935}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Expressed in fetal brain. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Expressed in fetal brain. {ECO:0000305}.	calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell communication [GO:0007154]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; modulation of excitatory postsynaptic potential [GO:0098815]; monoatomic ion transport [GO:0006811]; myelination [GO:0042552]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; oligodendrocyte differentiation [GO:0048709]; regulation of cardiac conduction [GO:1903779]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]	anchoring junction [GO:0070161]; axon [GO:0030424]; axon terminus [GO:0043679]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; synapse [GO:0045202]	calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential [GO:0099580]	anchoring junction [GO:0070161]; axon [GO:0030424]; axon terminus [GO:0043679]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; synapse [GO:0045202]; calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential [GO:0099580]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell communication [GO:0007154]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; modulation of excitatory postsynaptic potential [GO:0098815]; monoatomic ion transport [GO:0006811]; myelination [GO:0042552]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; oligodendrocyte differentiation [GO:0048709]; regulation of cardiac conduction [GO:1903779]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21959935}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:P70549}. Cell projection, dendrite {ECO:0000250|UniProtKB:P70549}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P70549}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:S4R2P9}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:S4R2P9}. Cell junction {ECO:0000250|UniProtKB:S4R2P9}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:S4R2P9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:S4R2P9}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21959935}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:21959935}; Multi-pass membrane protein {ECO:0000250|UniProtKB:S4R2P9}. Note=Detected at neuromuscular junctions. {ECO:0000250|UniProtKB:S4R2P9}.
P57105	reviewed	SYJ2B_HUMAN	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25)	SYNJ2BP OMP25	Homo sapiens (Human)	145	FUNCTION: Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. {ECO:0000250|UniProtKB:Q9D6K5}.		negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of sprouting angiogenesis [GO:1903671]; protein targeting [GO:0006605]; regulation of endocytosis [GO:0030100]; regulation of Notch signaling pathway [GO:0008593]; Rho protein signal transduction [GO:0007266]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of sprouting angiogenesis [GO:1903671]; protein targeting [GO:0006605]; regulation of endocytosis [GO:0030100]; regulation of Notch signaling pathway [GO:0008593]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:32973005}.
P57678	reviewed	GEMI4_HUMAN	Gem-associated protein 4 (Gemin-4) (Component of gems 4) (p97)	GEMIN4	Homo sapiens (Human)	1058	FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:18984161}.		rRNA processing [GO:0006364]; spliceosomal snRNP assembly [GO:0000387]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Gemini of coiled bodies [GO:0097504]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]	ribonucleoprotein complex binding [GO:0043021]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Gemini of coiled bodies [GO:0097504]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; ribonucleoprotein complex binding [GO:0043021]; rRNA processing [GO:0006364]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs and in the nucleolus.
P57679	reviewed	EVC_HUMAN	EvC complex member EVC (DWF-1) (Ellis-van Creveld syndrome protein)	EVC	Homo sapiens (Human)	992	FUNCTION: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development. {ECO:0000250|UniProtKB:P57680}.		cartilage development [GO:0051216]; endochondral bone growth [GO:0003416]; muscle organ development [GO:0007517]; positive regulation of smoothened signaling pathway [GO:0045880]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]	ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; plasma membrane protein complex [GO:0098797]		ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; plasma membrane protein complex [GO:0098797]; cartilage development [GO:0051216]; endochondral bone growth [GO:0003416]; muscle organ development [GO:0007517]; positive regulation of smoothened signaling pathway [GO:0045880]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P57680}; Single-pass membrane protein {ECO:0000250|UniProtKB:P57680}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P57680}. Cell projection, cilium {ECO:0000250|UniProtKB:P57680}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:P57680}. Note=EVC2 is required for the localization of EVC at the base of primary cilia. The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner. {ECO:0000250|UniProtKB:P57680}.
P57682	reviewed	KLF3_HUMAN	Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2)	KLF3 BKLF	Homo sapiens (Human)	345	FUNCTION: Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.	cellular response to peptide [GO:1901653]; hemopoiesis [GO:0030097]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to peptide [GO:1901653]; hemopoiesis [GO:0030097]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P57721	reviewed	PCBP3_HUMAN	Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1)	PCBP3 PCBP3-OT1 PCBP3OT	Homo sapiens (Human)	371	FUNCTION: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}.		mRNA metabolic process [GO:0016071]; regulation of gene expression [GO:0010468]; regulation of RNA metabolic process [GO:0051252]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	C-rich single-stranded DNA binding [GO:1990829]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; C-rich single-stranded DNA binding [GO:1990829]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA metabolic process [GO:0016071]; regulation of gene expression [GO:0010468]; regulation of RNA metabolic process [GO:0051252]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14612387}.
P57727	reviewed	TMPS3_HUMAN	Transmembrane protease serine 3 (EC 3.4.21.-) (Serine protease TADG-12) (Tumor-associated differentially-expressed gene 12 protein)	TMPRSS3 ECHOS1 TADG12 UNQ323/PRO382	Homo sapiens (Human)	454	FUNCTION: Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). {ECO:0000250, ECO:0000269|PubMed:12393794}.	MISCELLANEOUS: [Isoform 6]: Has a predicted N-terminal signal sequence, indicating it may be secreted. Expressed in retina, lung, liver, pancreas, placenta and kidney. {ECO:0000305}.	intracellular sodium ion homeostasis [GO:0006883]; proteolysis [GO:0006508]; sensory perception of sound [GO:0007605]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; neuronal cell body [GO:0043025]	serine-type endopeptidase activity [GO:0004252]; sodium channel regulator activity [GO:0017080]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; serine-type endopeptidase activity [GO:0004252]; sodium channel regulator activity [GO:0017080]; intracellular sodium ion homeostasis [GO:0006883]; proteolysis [GO:0006508]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12393794}; Single-pass type II membrane protein {ECO:0000269|PubMed:12393794}.
P57729	reviewed	RAB38_HUMAN	Ras-related protein Rab-38 (Melanoma antigen NY-MEL-1)	RAB38	Homo sapiens (Human)	211	FUNCTION: May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:Q8QZZ8, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:23084991}.		endosome to melanosome transport [GO:0035646]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; mitochondrion organization [GO:0007005]; phagosome acidification [GO:0090383]; platelet dense granule organization [GO:0060155]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; positive regulation of protein localization to cell periphery [GO:1904377]; protein localization to membrane [GO:0072657]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]	cell body [GO:0044297]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	AP-1 adaptor complex binding [GO:0035650]; AP-3 adaptor complex binding [GO:0035651]; BLOC-2 complex binding [GO:0036461]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]	cell body [GO:0044297]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; AP-1 adaptor complex binding [GO:0035650]; AP-3 adaptor complex binding [GO:0035651]; BLOC-2 complex binding [GO:0036461]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; endosome to melanosome transport [GO:0035646]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; mitochondrion organization [GO:0007005]; phagosome acidification [GO:0090383]; platelet dense granule organization [GO:0060155]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; positive regulation of protein localization to cell periphery [GO:1904377]; protein localization to membrane [GO:0072657]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome {ECO:0000269|PubMed:12643545}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome membrane {ECO:0000269|PubMed:23084991}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991). {ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:23084991}.
P57730	reviewed	CAR18_HUMAN	Caspase recruitment domain-containing protein 18 (Caspase-1 inhibitor Iceberg)	CARD18 ICEBERG UNQ5804/PRO19611	Homo sapiens (Human)	90	FUNCTION: Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B. {ECO:0000269|PubMed:11051551}.		inflammatory response [GO:0006954]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of protein binding [GO:0032091]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	protein-containing complex [GO:0032991]	CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase inhibitor activity [GO:0004869]	protein-containing complex [GO:0032991]; CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; inflammatory response [GO:0006954]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of protein binding [GO:0032091]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	
P57735	reviewed	RAB25_HUMAN	Ras-related protein Rab-25 (CATX-8)	RAB25 CATX8	Homo sapiens (Human)	213	FUNCTION: Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). {ECO:0000250|UniProtKB:E2RQ15, ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:Q9WTL2, ECO:0000269|PubMed:17925226}.		epithelial cell morphogenesis [GO:0003382]; exocytosis [GO:0006887]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; protein transport [GO:0015031]; pseudopodium organization [GO:0031268]; regulation of vesicle-mediated transport [GO:0060627]	cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; pseudopodium membrane [GO:0031260]; recycling endosome [GO:0055037]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]	cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; pseudopodium membrane [GO:0031260]; recycling endosome [GO:0055037]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; epithelial cell morphogenesis [GO:0003382]; exocytosis [GO:0006887]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; protein transport [GO:0015031]; pseudopodium organization [GO:0031268]; regulation of vesicle-mediated transport [GO:0060627]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, pseudopodium membrane {ECO:0000269|PubMed:17925226}. Cytoplasmic vesicle {ECO:0000269|PubMed:17925226}. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. {ECO:0000269|PubMed:17925226}.
P57737	reviewed	CORO7_HUMAN	Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog)	CORO7	Homo sapiens (Human)	925	FUNCTION: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}.		actin filament polymerization [GO:0030041]; cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; positive regulation of hippo signaling [GO:0035332]; protein transport [GO:0015031]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	actin binding [GO:0003779]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; actin binding [GO:0003779]; actin filament polymerization [GO:0030041]; cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; positive regulation of hippo signaling [GO:0035332]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.
P57739	reviewed	CLD2_HUMAN	Claudin-2 (SP82)	CLDN2 PSEC0059 SP82 UNQ705/PRO1356	Homo sapiens (Human)	230	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250|UniProtKB:O88552}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell-cell adhesion [GO:0098609]	bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell-cell adhesion [GO:0098609]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:O88552}. Cell membrane {ECO:0000250|UniProtKB:O88552}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O88552}.
P57740	reviewed	NU107_HUMAN	Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107)	NUP107	Homo sapiens (Human)	925	FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}.		female gonad development [GO:0008585]; mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606]	cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; structural constituent of nuclear pore [GO:0017056]; female gonad development [GO:0008585]; mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:26411495}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:26411495}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11564755}. Note=Located on both the cytoplasmic and nuclear sides of the NPC core structure (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). Dissociates from the dissasembled NPC structure late during prophase of mitosis (PubMed:11564755). {ECO:0000269|PubMed:11564755}.
P57764	reviewed	GSDMD_HUMAN	Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40]	GSDMD DFNA5L GSDMDC1 FKSG10	Homo sapiens (Human)	484	FUNCTION: [Gasdermin-D]: Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27281216). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:27281216). {ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26375259, ECO:0000269|PubMed:27281216}.; FUNCTION: [Gasdermin-D, N-terminal]: Promotes pyroptosis in response to microbial infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27418190, PubMed:28392147, PubMed:32820063, PubMed:34289345). Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1, CASP4 or CASP5 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216, PubMed:29898893, PubMed:36227980). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukin-1 (IL1B and IL18) and triggering pyroptosis (PubMed:27418190, PubMed:27281216, PubMed:29898893, PubMed:33883744). Gasdermin pores also allow the release of mature caspase-7 (CASP7) (By similarity). In some, but not all, cells types, pyroptosis is followed by pyroptotic cell death, which is caused by downstream activation of ninjurins (NINJ1 or NINJ2), which mediate membrane rupture (cytolysis) (PubMed:33472215, PubMed:37198476). Also forms pores in the mitochondrial membrane, resulting in release of mitochondrial DNA (mtDNA) into the cytosol (By similarity). Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity). Also active in response to MAP3K7/TAK1 inactivation by Yersinia toxin YopJ, which triggers cleavage by CASP8 and subsequent activation (By similarity). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin (PubMed:27281216). Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216). {ECO:0000250|UniProtKB:Q9D8T2, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26375259, ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:27418190, ECO:0000269|PubMed:28392147, ECO:0000269|PubMed:29898893, ECO:0000269|PubMed:32820063, ECO:0000269|PubMed:33472215, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:36227980, ECO:0000269|PubMed:37198476}.; FUNCTION: [Gasdermin-D, p13]: Transcription coactivator produced by the cleavage by CASP3 or CASP7 in the upper small intestine in response to dietary antigens (By similarity). Required to maintain food tolerance in small intestine: translocates to the nucleus and acts as a coactivator for STAT1 to induce the transcription of CIITA and MHC class II molecules, which in turn induce type 1 regulatory T (Tr1) cells in upper small intestine (By similarity). {ECO:0000250|UniProtKB:Q9D8T2}.; FUNCTION: [Gasdermin-D, p40]: Produced by the cleavage by papain allergen (PubMed:35794369). After cleavage, moves to the plasma membrane and homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the specific release of mature interleukin-33 (IL33), promoting type 2 inflammatory immune response (PubMed:35794369). {ECO:0000269|PubMed:35794369}.		cellular response to extracellular stimulus [GO:0031668]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; pore complex assembly [GO:0046931]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; protein homooligomerization [GO:0051260]; protein secretion [GO:0009306]; pyroptosis [GO:0070269]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; NLRP3 inflammasome complex [GO:0072559]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; wide pore channel activity [GO:0022829]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; NLRP3 inflammasome complex [GO:0072559]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; wide pore channel activity [GO:0022829]; cellular response to extracellular stimulus [GO:0031668]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; pore complex assembly [GO:0046931]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; protein homooligomerization [GO:0051260]; protein secretion [GO:0009306]; pyroptosis [GO:0070269]	SUBCELLULAR LOCATION: [Gasdermin-D]: Cytoplasm, cytosol {ECO:0000269|PubMed:27281216}. Inflammasome {ECO:0000250|UniProtKB:Q9D8T2}. Note=In response to a canonical inflammasome stimulus, such as nigericin, recruited to NLRP3 inflammasone with similar kinetics to that of uncleaved CASP1 precursor. {ECO:0000250|UniProtKB:Q9D8T2}.; SUBCELLULAR LOCATION: [Gasdermin-D, N-terminal]: Cell membrane {ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:36227980}; Multi-pass membrane protein {ECO:0000269|PubMed:33883744, ECO:0000305|PubMed:29898893}. Secreted {ECO:0000250|UniProtKB:Q9D8T2}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q9D8T2}. Note=Released in the extracellular milieu following pyroptosis. {ECO:0000250|UniProtKB:Q9D8T2}.; SUBCELLULAR LOCATION: [Gasdermin-D, N-terminal]: Cytoplasm, cytosol {ECO:0000269|PubMed:36227980}. Note=(Microbial infection) Upon infection by M.tuberculosis, localization to cell membrane is prevented by M.tuberculosis phosphatase PtpB that catalyzes dephosphorylation of phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol 4-phosphate, thereby inhibiting the membrane targeting of Gasdermin-D, N-terminal and subsequent cytokine release and pyroptosis. {ECO:0000269|PubMed:36227980}.; SUBCELLULAR LOCATION: [Gasdermin-D, p13]: Nucleus {ECO:0000250|UniProtKB:Q9D8T2}.; SUBCELLULAR LOCATION: [Gasdermin-D, C-terminal]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D8T2}.
P57768	reviewed	SNX16_HUMAN	Sorting nexin-16	SNX16	Homo sapiens (Human)	344	FUNCTION: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. {ECO:0000269|PubMed:12813048, ECO:0000269|PubMed:15951806}.		early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; protein targeting to lysosome [GO:0006622]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extrinsic component of endosome membrane [GO:0031313]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]	identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extrinsic component of endosome membrane [GO:0031313]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; protein targeting to lysosome [GO:0006622]	SUBCELLULAR LOCATION: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm {ECO:0000250}. Lysosome {ECO:0000250}.
P57771	reviewed	RGS8_HUMAN	Regulator of G-protein signaling 8 (RGS8)	RGS8	Homo sapiens (Human)	180	FUNCTION: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity). {ECO:0000250|UniProtKB:P49804, ECO:0000269|PubMed:18434541}.		G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of dopamine receptor signaling pathway [GO:0060159]	cytoplasmic side of plasma membrane [GO:0009898]; dendrite [GO:0030425]; neuronal cell body membrane [GO:0032809]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytoplasmic side of plasma membrane [GO:0009898]; dendrite [GO:0030425]; neuronal cell body membrane [GO:0032809]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of dopamine receptor signaling pathway [GO:0060159]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250|UniProtKB:P49804}. Membrane {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250|UniProtKB:P49804}. Perikaryon {ECO:0000250|UniProtKB:P49804}. Cell projection, dendrite {ECO:0000250|UniProtKB:P49804}. Nucleus {ECO:0000250|UniProtKB:P49804}. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1. {ECO:0000250|UniProtKB:P49804}.
P57772	reviewed	SELB_HUMAN	Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific)	EEFSEC SELB	Homo sapiens (Human)	596	FUNCTION: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.		selenocysteine incorporation [GO:0001514]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribonucleoprotein complex binding [GO:0043021]; selenocysteine insertion sequence binding [GO:0035368]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribonucleoprotein complex binding [GO:0043021]; selenocysteine insertion sequence binding [GO:0035368]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049]; selenocysteine incorporation [GO:0001514]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
P57789	reviewed	KCNKA_HUMAN	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit)	KCNK10 TREK2	Homo sapiens (Human)	538	FUNCTION: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.		memory [GO:0007613]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]; signal transduction [GO:0007165]; stabilization of membrane potential [GO:0030322]	plasma membrane [GO:0005886]	outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; memory [GO:0007613]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]; signal transduction [GO:0007165]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P57796	reviewed	CABP4_HUMAN	Calcium-binding protein 4 (CaBP4)	CABP4	Homo sapiens (Human)	275	FUNCTION: Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity). {ECO:0000250}.		photoreceptor cell morphogenesis [GO:0008594]; phototransduction [GO:0007602]; retinal bipolar neuron differentiation [GO:0060040]; retinal cone cell development [GO:0046549]; signal transduction [GO:0007165]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; synapse [GO:0045202]; terminal bouton [GO:0043195]	calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; synapse [GO:0045202]; terminal bouton [GO:0043195]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; transmembrane transporter binding [GO:0044325]; photoreceptor cell morphogenesis [GO:0008594]; phototransduction [GO:0007602]; retinal bipolar neuron differentiation [GO:0060040]; retinal cone cell development [GO:0046549]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19338761}. Presynapse {ECO:0000250|UniProtKB:Q8VHC5}. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors. {ECO:0000250|UniProtKB:Q8VHC5}.
P58004	reviewed	SESN2_HUMAN	Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene)	SESN2 Hi95 SEST2	Homo sapiens (Human)	480	FUNCTION: Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190, PubMed:35114100, PubMed:35831510, PubMed:36528027). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821). {ECO:0000269|PubMed:15105503, ECO:0000269|PubMed:18692468, ECO:0000269|PubMed:19113821, ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:24947615, ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26449471, ECO:0000269|PubMed:26586190, ECO:0000269|PubMed:26612684, ECO:0000269|PubMed:35114100, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}.		cellular oxidant detoxification [GO:0098869]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to glucose starvation [GO:0042149]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; fatty acid beta-oxidation [GO:0006635]; glucose homeostasis [GO:0042593]; glucose import [GO:0046323]; mitochondrial DNA metabolic process [GO:0032042]; negative regulation of cell growth [GO:0030308]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of lipophagy [GO:1904504]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of TORC1 signaling [GO:1904263]; reactive oxygen species metabolic process [GO:0072593]; regulation of gluconeogenesis [GO:0006111]; regulation of protein phosphorylation [GO:0001932]; regulation of response to reactive oxygen species [GO:1901031]; regulation of TORC1 signaling [GO:1903432]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; triglyceride homeostasis [GO:0070328]	Atg1/ULK1 kinase complex [GO:1990316]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; TORC2 complex [GO:0031932]	GDP-dissociation inhibitor activity [GO:0005092]; leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]; PH domain binding [GO:0042731]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; sulfiredoxin activity [GO:0032542]	Atg1/ULK1 kinase complex [GO:1990316]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; TORC2 complex [GO:0031932]; GDP-dissociation inhibitor activity [GO:0005092]; leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]; PH domain binding [GO:0042731]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; sulfiredoxin activity [GO:0032542]; cellular oxidant detoxification [GO:0098869]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to glucose starvation [GO:0042149]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; fatty acid beta-oxidation [GO:0006635]; glucose homeostasis [GO:0042593]; glucose import [GO:0046323]; mitochondrial DNA metabolic process [GO:0032042]; negative regulation of cell growth [GO:0030308]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of lipophagy [GO:1904504]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of TORC1 signaling [GO:1904263]; reactive oxygen species metabolic process [GO:0072593]; regulation of gluconeogenesis [GO:0006111]; regulation of protein phosphorylation [GO:0001932]; regulation of response to reactive oxygen species [GO:1901031]; regulation of TORC1 signaling [GO:1903432]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15105503}.
P58005	reviewed	SESN3_HUMAN	Sestrin-3 (EC 1.11.1.-)	SESN3 SEST3	Homo sapiens (Human)	492	FUNCTION: May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). {ECO:0000250|UniProtKB:P58004, ECO:0000250|UniProtKB:Q9CYP7, ECO:0000269|PubMed:25263562}.		cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; glucose homeostasis [GO:0042593]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of response to reactive oxygen species [GO:1901031]; response to insulin [GO:0032868]; TORC2 signaling [GO:0038203]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; TORC2 complex [GO:0031932]	leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; TORC2 complex [GO:0031932]; leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; glucose homeostasis [GO:0042593]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of response to reactive oxygen species [GO:1901031]; response to insulin [GO:0032868]; TORC2 signaling [GO:0038203]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:25263562}.
P58012	reviewed	FOXL2_HUMAN	Forkhead box protein L2	FOXL2	Homo sapiens (Human)	376	FUNCTION: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}.		anatomical structure morphogenesis [GO:0009653]; apoptotic DNA fragmentation [GO:0006309]; cell differentiation [GO:0030154]; embryonic eye morphogenesis [GO:0048048]; extraocular skeletal muscle development [GO:0002074]; female somatic sex determination [GO:0019101]; granulosa cell differentiation [GO:0060014]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte growth [GO:0001555]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of luteinizing hormone secretion [GO:0033686]; regulation of transcription by RNA polymerase II [GO:0006357]; single fertilization [GO:0007338]; uterus development [GO:0060065]	chromatin [GO:0000785]; Flemming body [GO:0090543]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type endopeptidase regulator activity involved in apoptotic process [GO:0043028]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; ubiquitin conjugating enzyme binding [GO:0031624]	chromatin [GO:0000785]; Flemming body [GO:0090543]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type endopeptidase regulator activity involved in apoptotic process [GO:0043028]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; ubiquitin conjugating enzyme binding [GO:0031624]; anatomical structure morphogenesis [GO:0009653]; apoptotic DNA fragmentation [GO:0006309]; cell differentiation [GO:0030154]; embryonic eye morphogenesis [GO:0048048]; extraocular skeletal muscle development [GO:0002074]; female somatic sex determination [GO:0019101]; granulosa cell differentiation [GO:0060014]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte growth [GO:0001555]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of luteinizing hormone secretion [GO:0033686]; regulation of transcription by RNA polymerase II [GO:0006357]; single fertilization [GO:0007338]; uterus development [GO:0060065]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:19744555}.
P58107	reviewed	EPIPL_HUMAN	Epiplakin (450 kDa epidermal antigen)	EPPK1 EPIPL	Homo sapiens (Human)	5088	FUNCTION: Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity). {ECO:0000250|UniProtKB:Q8R0W0, ECO:0000269|PubMed:15671067, ECO:0000269|PubMed:23398049, ECO:0000269|PubMed:27206504}.		intermediate filament bundle assembly [GO:0045110]; intermediate filament organization [GO:0045109]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of keratinocyte migration [GO:0051548]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of wound healing [GO:0061045]; regulation of epithelium regeneration [GO:1905041]; wound healing [GO:0042060]	apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; membrane [GO:0016020]; perinucleolar compartment [GO:0097356]	intermediate filament binding [GO:0019215]; keratin filament binding [GO:1990254]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]	apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; membrane [GO:0016020]; perinucleolar compartment [GO:0097356]; intermediate filament binding [GO:0019215]; keratin filament binding [GO:1990254]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; intermediate filament bundle assembly [GO:0045110]; intermediate filament organization [GO:0045109]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of keratinocyte migration [GO:0051548]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of wound healing [GO:0061045]; regulation of epithelium regeneration [GO:1905041]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15671067, ECO:0000269|PubMed:23398049}. Cell junction, hemidesmosome {ECO:0000269|PubMed:23398049}. Cell junction, tight junction {ECO:0000269|PubMed:23398049}. Cell projection {ECO:0000269|PubMed:23398049}. Apicolateral cell membrane {ECO:0000250|UniProtKB:Q8R0W0}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8R0W0}. Cell junction {ECO:0000250|UniProtKB:Q8R0W0}. Note=May move dynamically from bundling intermediate filaments in the cytoplasm or at the cell periphery and reinforcing them (PubMed:23398049). Decorates the keratin intermediate filaments (IF) network and partially that of vimentin (PubMed:15671067). {ECO:0000269|PubMed:15671067, ECO:0000269|PubMed:23398049}.
P58215	reviewed	LOXL3_HUMAN	Lysyl oxidase homolog 3 (EC 1.4.3.-) (EC 1.4.3.13) (Lysyl oxidase-like protein 3)	LOXL3 LOXL	Homo sapiens (Human)	753	FUNCTION: Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600). {ECO:0000250|UniProtKB:Q9Z175, ECO:0000269|PubMed:17018530, ECO:0000269|PubMed:28065600}.; FUNCTION: [Isoform 1]: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII (PubMed:17018530). {ECO:0000269|PubMed:17018530}.; FUNCTION: [Isoform 2]: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV (PubMed:17018530). {ECO:0000269|PubMed:17018530}.	MISCELLANEOUS: [Isoform 2]: Misses three SRCR domains. {ECO:0000305}.	collagen fibril organization [GO:0030199]; epithelial to mesenchymal transition [GO:0001837]; fibronectin fibril organization [GO:1905590]; inflammatory response [GO:0006954]; lung development [GO:0030324]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; peptidyl-lysine oxidation [GO:0018057]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; roof of mouth development [GO:0060021]; somite development [GO:0061053]; spinal cord development [GO:0021510]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]	copper ion binding [GO:0005507]; fibronectin binding [GO:0001968]; protein-lysine 6-oxidase activity [GO:0004720]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; copper ion binding [GO:0005507]; fibronectin binding [GO:0001968]; protein-lysine 6-oxidase activity [GO:0004720]; collagen fibril organization [GO:0030199]; epithelial to mesenchymal transition [GO:0001837]; fibronectin fibril organization [GO:1905590]; inflammatory response [GO:0006954]; lung development [GO:0030324]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; peptidyl-lysine oxidation [GO:0018057]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; roof of mouth development [GO:0060021]; somite development [GO:0061053]; spinal cord development [GO:0021510]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250|UniProtKB:Q9Z175}. Cytoplasm {ECO:0000269|PubMed:28065600}. Nucleus {ECO:0000269|PubMed:28065600}. Note=It is unclear how LOXL3 is both intracellular (cytoplasmic and nuclear) and extracellular: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, the intracellular location is clearly reported and at least another protein of the family (LOXL2) also has intracellular and extracellular localization despite the presence of a signal sequence (PubMed:28065600). {ECO:0000269|PubMed:28065600}.; SUBCELLULAR LOCATION: [Isoform 1]: Secreted, extracellular space {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17018530}. Secreted, extracellular space {ECO:0000269|PubMed:17018530}.
P58304	reviewed	VSX2_HUMAN	Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10)	VSX2 CHX10 HOX10	Homo sapiens (Human)	361	FUNCTION: Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters (PubMed:27301076). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). May play a role in specification of V2a interneurons during spinal cord development (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1 (PubMed:17919464, PubMed:27477290). Acts as a positive transcriptional regulator of NXNL1; regulation is significantly increased in synergy with VSX1 (By similarity). Acts as a negative transcriptional regulator of MITF (By similarity). Represses SAG transcription by competitive inhibition of ISL1-LHX3 response elements (PubMed:16236706, PubMed:27477290). Binds to the photoreceptor conserved element-1 (PCE-1) in the promoter of rod photoreceptor arrestin SAG and acts as a transcriptional repressor (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Involved in the development of retinal ganglion cells (RGCs) which leads to release of SHH by RGCs, promoting Hedgehog signaling and subsequent proliferation of retinal progenitor cells (By similarity). Participates in the development of the cells of the inner nuclear layer, by promoting postnatal differentiation of bipolar cells with a comparable inhibition of rod cell differentiation (By similarity). May play a role in the maintenance of neural retina identity during development by regulation of canonical Wnt genes and CTNNB1 localization, suggesting a role in the regulation of canonical Wnt signaling (PubMed:27301076). {ECO:0000250|UniProtKB:Q61412, ECO:0000269|PubMed:16236706, ECO:0000269|PubMed:17919464, ECO:0000269|PubMed:27301076, ECO:0000269|PubMed:27477290}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61412}.
P58335	reviewed	ANTR2_HUMAN	Anthrax toxin receptor 2 (Capillary morphogenesis gene 2 protein) (CMG-2)	ANTXR2 CMG2	Homo sapiens (Human)	489	FUNCTION: Necessary for cellular interactions with laminin and the extracellular matrix. {ECO:0000269|PubMed:11683410, ECO:0000269|PubMed:12973667}.; FUNCTION: (Microbial infection) Receptor for the protective antigen (PA) of B.anthracis (PubMed:12700348, PubMed:15243628, PubMed:15326297). Binding of PA leads to heptamerization of the receptor-PA complex (PubMed:12700348, PubMed:15243628, PubMed:15326297). Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway (PubMed:12551953, PubMed:15337774). In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm (PubMed:12551953, PubMed:15337774). {ECO:0000269|PubMed:12551953, ECO:0000269|PubMed:12700348, ECO:0000269|PubMed:15243628, ECO:0000269|PubMed:15326297, ECO:0000269|PubMed:15337774}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12700348}; Single-pass type I membrane protein {ECO:0000255}. Note=Expressed at the cell surface. {ECO:0000269|PubMed:12700348}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11683410}; Single-pass type I membrane protein {ECO:0000255}. Note=Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane. {ECO:0000269|PubMed:11683410}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.
P58340	reviewed	MLF1_HUMAN	Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1)	MLF1	Homo sapiens (Human)	268	FUNCTION: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269|PubMed:15861129}.		cell cycle [GO:0007049]; DNA-templated transcription [GO:0006351]; myeloid progenitor cell differentiation [GO:0002318]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of DNA-templated transcription [GO:0006355]; regulation of signal transduction by p53 class mediator [GO:1901796]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	DNA binding [GO:0003677]; protein domain specific binding [GO:0019904]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; DNA binding [GO:0003677]; protein domain specific binding [GO:0019904]; cell cycle [GO:0007049]; DNA-templated transcription [GO:0006351]; myeloid progenitor cell differentiation [GO:0002318]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of DNA-templated transcription [GO:0006355]; regulation of signal transduction by p53 class mediator [GO:1901796]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QWV4}. Nucleus {ECO:0000250|UniProtKB:Q9QWV4}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9QWV4}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9QWV4}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9QWV4}.
P58397	reviewed	ATS12_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-)	ADAMTS12 UNQ1918/PRO4389	Homo sapiens (Human)	1594	FUNCTION: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. {ECO:0000269|PubMed:16611630, ECO:0000269|PubMed:17895370, ECO:0000269|PubMed:18485748}.		cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; cellular response to BMP stimulus [GO:0071773]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; negative regulation of cellular response to hepatocyte growth factor stimulus [GO:2001113]; negative regulation of cellular response to vascular endothelial growth factor stimulus [GO:1902548]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of hepatocyte growth factor receptor signaling pathway [GO:1902203]; ossification involved in bone maturation [GO:0043931]; proteoglycan catabolic process [GO:0030167]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of endothelial tube morphogenesis [GO:1901509]; regulation of inflammatory response [GO:0050727]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; cellular response to BMP stimulus [GO:0071773]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; negative regulation of cellular response to hepatocyte growth factor stimulus [GO:2001113]; negative regulation of cellular response to vascular endothelial growth factor stimulus [GO:1902548]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of hepatocyte growth factor receptor signaling pathway [GO:1902203]; ossification involved in bone maturation [GO:0043931]; proteoglycan catabolic process [GO:0030167]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of endothelial tube morphogenesis [GO:1901509]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
P58400	reviewed	NRX1B_HUMAN	Neurexin-1-beta (Neurexin I-beta)	NRXN1	Homo sapiens (Human)	472	FUNCTION: Neuronal cell surface protein involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. Plays a role in formation of synaptic junctions. {ECO:0000250|UniProtKB:P0DI97, ECO:0000250|UniProtKB:Q63373}.		adult behavior [GO:0030534]; angiogenesis [GO:0001525]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion involved in synapse maturation [GO:0090125]; cellular response to calcium ion [GO:0071277]; cerebellar granule cell differentiation [GO:0021707]; establishment of protein localization [GO:0045184]; gamma-aminobutyric acid receptor clustering [GO:0097112]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; guanylate kinase-associated protein clustering [GO:0097117]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; learning [GO:0007612]; maintenance of synapse structure [GO:0099558]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of gene expression [GO:0010629]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuron cell-cell adhesion [GO:0007158]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; neuronal signal transduction [GO:0023041]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of gene expression [GO:0010628]; positive regulation of neuromuscular synaptic transmission [GO:1900075]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of presynaptic active zone assembly [GO:1905520]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein localization to synapse [GO:0035418]; protein-containing complex assembly involved in synapse maturation [GO:0090126]; receptor localization to synapse [GO:0097120]; regulation of AMPA receptor activity [GO:2000311]; regulation of NMDA receptor activity [GO:2000310]; signal transduction [GO:0007165]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse maturation [GO:0060074]; synaptic vesicle clustering [GO:0097091]; vocalization behavior [GO:0071625]	axonal growth cone [GO:0044295]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; excitatory synapse [GO:0060076]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; inhibitory synapse [GO:0060077]; neuromuscular junction [GO:0031594]; neuron to neuron synapse [GO:0098984]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; protein complex involved in cell-cell adhesion [GO:0098635]; vesicle [GO:0031982]	calcium-dependent protein binding [GO:0048306]; cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]; type 1 fibroblast growth factor receptor binding [GO:0005105]	axonal growth cone [GO:0044295]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; excitatory synapse [GO:0060076]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; inhibitory synapse [GO:0060077]; neuromuscular junction [GO:0031594]; neuron to neuron synapse [GO:0098984]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; protein complex involved in cell-cell adhesion [GO:0098635]; vesicle [GO:0031982]; calcium-dependent protein binding [GO:0048306]; cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]; type 1 fibroblast growth factor receptor binding [GO:0005105]; adult behavior [GO:0030534]; angiogenesis [GO:0001525]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion involved in synapse maturation [GO:0090125]; cellular response to calcium ion [GO:0071277]; cerebellar granule cell differentiation [GO:0021707]; establishment of protein localization [GO:0045184]; gamma-aminobutyric acid receptor clustering [GO:0097112]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; guanylate kinase-associated protein clustering [GO:0097117]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; learning [GO:0007612]; maintenance of synapse structure [GO:0099558]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of gene expression [GO:0010629]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuron cell-cell adhesion [GO:0007158]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; neuronal signal transduction [GO:0023041]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of gene expression [GO:0010628]; positive regulation of neuromuscular synaptic transmission [GO:1900075]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of presynaptic active zone assembly [GO:1905520]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein localization to synapse [GO:0035418]; protein-containing complex assembly involved in synapse maturation [GO:0090126]; receptor localization to synapse [GO:0097120]; regulation of AMPA receptor activity [GO:2000311]; regulation of NMDA receptor activity [GO:2000310]; signal transduction [GO:0007165]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse maturation [GO:0060074]; synaptic vesicle clustering [GO:0097091]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q63373}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q63373}.
P58401	reviewed	NRX2B_HUMAN	Neurexin-2-beta (Neurexin II-beta)	NRXN2	Homo sapiens (Human)	666	FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.		neuron cell-cell adhesion [GO:0007158]; signal transduction [GO:0007165]	cell projection [GO:0042995]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; transmembrane signaling receptor activity [GO:0004888]	cell projection [GO:0042995]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; transmembrane signaling receptor activity [GO:0004888]; neuron cell-cell adhesion [GO:0007158]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
P58418	reviewed	CLRN1_HUMAN	Clarin-1 (Usher syndrome type-3 protein)	CLRN1 USH3A	Homo sapiens (Human)	232	FUNCTION: May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina. {ECO:0000269|PubMed:12080385}.		actin filament organization [GO:0007015]; auditory receptor cell stereocilium organization [GO:0060088]; cell motility [GO:0048870]; equilibrioception [GO:0050957]; photoreceptor cell maintenance [GO:0045494]; positive regulation of lamellipodium assembly [GO:0010592]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	basal part of cell [GO:0045178]; lamellipodium [GO:0030027]; microtubule cytoskeleton [GO:0015630]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; trans-Golgi network transport vesicle [GO:0030140]		basal part of cell [GO:0045178]; lamellipodium [GO:0030027]; microtubule cytoskeleton [GO:0015630]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; trans-Golgi network transport vesicle [GO:0030140]; actin filament organization [GO:0007015]; auditory receptor cell stereocilium organization [GO:0060088]; cell motility [GO:0048870]; equilibrioception [GO:0050957]; photoreceptor cell maintenance [GO:0045494]; positive regulation of lamellipodium assembly [GO:0010592]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21310491}; Multi-pass membrane protein {ECO:0000255}.
P58499	reviewed	FAM3B_HUMAN	Protein FAM3B (Cytokine-like protein 2-21) (Pancreatic-derived factor) (PANDER)	FAM3B C21orf11 C21orf76 PRED44 UNQ320/PRO365	Homo sapiens (Human)	235	FUNCTION: Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. {ECO:0000269|PubMed:16114871}.		apoptotic process [GO:0006915]; insulin secretion [GO:0030073]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; apoptotic process [GO:0006915]; insulin secretion [GO:0030073]	SUBCELLULAR LOCATION: Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.
P58546	reviewed	MTPN_HUMAN	Myotrophin (Protein V-1)	MTPN	Homo sapiens (Human)	118	FUNCTION: Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. {ECO:0000250, ECO:0000269|PubMed:10329199, ECO:0000269|PubMed:16895918, ECO:0000269|PubMed:20625546}.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN.	catecholamine metabolic process [GO:0006584]; cellular response to mechanical stimulus [GO:0071260]; cerebellar granule cell differentiation [GO:0021707]; neuron differentiation [GO:0030182]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell growth [GO:0030307]; positive regulation of macromolecule biosynthetic process [GO:0010557]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein metabolic process [GO:0051247]; regulation of barbed-end actin filament capping [GO:2000812]; regulation of cell size [GO:0008361]; regulation of striated muscle tissue development [GO:0016202]; regulation of translation [GO:0006417]; skeletal muscle tissue regeneration [GO:0043403]; striated muscle cell differentiation [GO:0051146]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	sequence-specific DNA binding [GO:0043565]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sequence-specific DNA binding [GO:0043565]; catecholamine metabolic process [GO:0006584]; cellular response to mechanical stimulus [GO:0071260]; cerebellar granule cell differentiation [GO:0021707]; neuron differentiation [GO:0030182]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell growth [GO:0030307]; positive regulation of macromolecule biosynthetic process [GO:0010557]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein metabolic process [GO:0051247]; regulation of barbed-end actin filament capping [GO:2000812]; regulation of cell size [GO:0008361]; regulation of striated muscle tissue development [GO:0016202]; regulation of translation [GO:0006417]; skeletal muscle tissue regeneration [GO:0043403]; striated muscle cell differentiation [GO:0051146]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
P58743	reviewed	S26A5_HUMAN	Prestin (Solute carrier family 26 member 5)	SLC26A5 PRES	Homo sapiens (Human)	744	FUNCTION: Voltage-sensitive motor protein that drives outer hair cell (OHC) electromotility (eM) and participates in sound amplification in the hearing organ (By similarity). Converts changes in the transmembrane electric potential into mechanical displacements resulting in the coupling of its expansion to movement of a charged voltage sensor across the lipid membrane (By similarity). The nature of the voltage sensor is not completely clear, and two models compete. In the first model, acts as an incomplete transporter where intracellular chloride anion acts as extrinsic voltage sensor that drives conformational change in the protein which is sufficient to produce a length change in the plane of the membrane and hence in the length of the OHC (By similarity). The second model in which multiple charged amino acid residues are distributed at the intracellular and extracellular membrane interfaces that form an intrinsic voltage sensor, whose movement produces the non-linear capacitance (NLC) (PubMed:34390643). However, the effective voltage sensor may be the result of a hybrid voltage sensor, assembled from intrinsic charge (charged residues) and extrinsic charge (bound anion) (By similarity). Notably, binding of anions to the anion-binding pocket partially neutralizes the intrinsic positive charge rather than to form an electrically negative sensor, therefore remaining charge may serve as voltage sensor that, after depolarization, moves from down (expanded state) to up (contracted) conformation, which is accompanied by an eccentric contraction of the intermembrane cross-sectional area of the protein as well as a major increase in the hydrophobic thickness of the protein having as consequences the plasma membrane thickening and the cell contraction after membrane depolarization (PubMed:34390643). The anion-binding pocket transits from the inward-open (Down) state, where it is exposed toward the intracellular solvent in the absence of anion, to the occluded (Up) state upon anion binding (PubMed:34390643). Salicylate competes for the anion-binding site and inhibits the voltage-sensor movement, and therefore inhibits the charge transfer and electromotility by displacing Cl(-) from the anion-binding site and by preventing the structural transitions to the contracted state (PubMed:34390643). In addition, can act as a weak Cl(-)/HCO3(-) antiporter across the cell membrane and so regulate the intracellular pH of the outer hair cells (OHCs), while firstly found as being unable to mediate electrogenic anion transport (By similarity). Moreover, supports a role in cardiac mechanical amplification serving as an elastic element to enhance the actomyosin- based sarcomere contraction system (By similarity). {ECO:0000250|UniProtKB:D7PC76, ECO:0000250|UniProtKB:Q99NH7, ECO:0000250|UniProtKB:Q9EPH0, ECO:0000250|UniProtKB:Q9JKQ2, ECO:0000269|PubMed:34390643}.		bicarbonate transport [GO:0015701]; chloride transport [GO:0006821]; cochlea development [GO:0090102]; fructose transmembrane transport [GO:0015755]; negative regulation of monoatomic ion transmembrane transport [GO:0034766]; positive regulation of cell motility [GO:2000147]; positive regulation of cell size [GO:0045793]; regulation of cell shape [GO:0008360]; regulation of membrane potential [GO:0042391]; response to auditory stimulus [GO:0010996]; response to ischemia [GO:0002931]; response to potassium ion [GO:0035864]; response to salicylic acid [GO:0009751]; response to thyroid hormone [GO:0097066]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]	basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; lateral wall of outer hair cell [GO:0120249]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; protein homodimerization activity [GO:0042803]; secondary active sulfate transmembrane transporter activity [GO:0008271]; spectrin binding [GO:0030507]; sulfate transmembrane transporter activity [GO:0015116]	basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; lateral wall of outer hair cell [GO:0120249]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; protein homodimerization activity [GO:0042803]; secondary active sulfate transmembrane transporter activity [GO:0008271]; spectrin binding [GO:0030507]; sulfate transmembrane transporter activity [GO:0015116]; bicarbonate transport [GO:0015701]; chloride transport [GO:0006821]; cochlea development [GO:0090102]; fructose transmembrane transport [GO:0015755]; negative regulation of monoatomic ion transmembrane transport [GO:0034766]; positive regulation of cell motility [GO:2000147]; positive regulation of cell size [GO:0045793]; regulation of cell shape [GO:0008360]; regulation of membrane potential [GO:0042391]; response to auditory stimulus [GO:0010996]; response to ischemia [GO:0002931]; response to potassium ion [GO:0035864]; response to salicylic acid [GO:0009751]; response to thyroid hormone [GO:0097066]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Lateral cell membrane {ECO:0000305|PubMed:34390643}; Multi-pass membrane protein {ECO:0000269|PubMed:34390643}. Note=Localized at the lateral cell membrane of outer hair cells (By similarity). Alters profoundly the shape of its surrounding lipid bilayer (PubMed:34390643). {ECO:0000250, ECO:0000250|UniProtKB:Q9JKQ2, ECO:0000269|PubMed:34390643}.
P58753	reviewed	TIRAP_HUMAN	Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)	TIRAP MAL	Homo sapiens (Human)	221	FUNCTION: Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6). {ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286, ECO:0000269|PubMed:21829704}.		3'-UTR-mediated mRNA stabilization [GO:0070935]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; cellular response to bacterial lipopeptide [GO:0071221]; cellular response to lipoteichoic acid [GO:0071223]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; myeloid cell differentiation [GO:0030099]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-15 production [GO:0032738]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of innate immune response [GO:0045088]; regulation of interferon-beta production [GO:0032648]; regulation of stress-activated MAPK cascade [GO:0032872]; response to lipopolysaccharide [GO:0032496]; TIRAP-dependent toll-like receptor 4 signaling pathway [GO:0035665]; toll-like receptor 4 signaling pathway [GO:0034142]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase C binding [GO:0005080]; protein-macromolecule adaptor activity [GO:0030674]; Toll-like receptor 2 binding [GO:0035663]; Toll-like receptor 4 binding [GO:0035662]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase C binding [GO:0005080]; protein-macromolecule adaptor activity [GO:0030674]; Toll-like receptor 2 binding [GO:0035663]; Toll-like receptor 4 binding [GO:0035662]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; cellular response to bacterial lipopeptide [GO:0071221]; cellular response to lipoteichoic acid [GO:0071223]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; myeloid cell differentiation [GO:0030099]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-15 production [GO:0032738]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of innate immune response [GO:0045088]; regulation of interferon-beta production [GO:0032648]; regulation of stress-activated MAPK cascade [GO:0032872]; response to lipopolysaccharide [GO:0032496]; TIRAP-dependent toll-like receptor 4 signaling pathway [GO:0035665]; toll-like receptor 4 signaling pathway [GO:0034142]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19948740}. Cell membrane {ECO:0000269|PubMed:19948740}. Membrane {ECO:0000269|PubMed:19948740}. Note=Colocalizes with DAB2IP at the plasma membrane.
P58876	reviewed	H2B1D_HUMAN	Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b)	H2BC5 H2BFB HIRIP2 HIST1H2BD	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	MISCELLANEOUS: The mouse orthologous protein seems not to exist.		cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P59044	reviewed	NLRP6_HUMAN	NACHT, LRR and PYD domains-containing protein 6 (Angiotensin II/vasopressin receptor) (PYRIN-containing APAF1-like protein 5)	NLRP6 NALP6 PYPAF5	Homo sapiens (Human)	892	FUNCTION: Acts as the sensor component of the NLRP6 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to maturation and secretion of IL1B and IL18 (PubMed:30392956, PubMed:34678144). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:30674671). Acts as a recognition receptor (PRR): recognizes and binds specific pathogens and other damage-associated signals, such as lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, or double stranded RNA (dsRNA) (PubMed:30392956, PubMed:34678144, PubMed:33377178). May also recognize and bind lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria; however, LPS is probably not a major activator of the NLRP6 inflammasome (PubMed:31932628, PubMed:34678144). Following LTA- or dsRNA-binding, NLRP6 undergoes liquid-liquid phase separation (LLPS), enhancing multivalent interactions, an essential step for the formation of the NLRP6 inflammasome polymeric complex (PubMed:34678144). The NLRP6 inflammasome acts by promoting recruitment of effector pro-inflammatory caspases (CASP1 and/or CASP4) that catalyze maturation and secretion of IL1B and IL18 in the extracellular milieu (PubMed:30674671, PubMed:12387869, PubMed:30392956, PubMed:34678144). The NLRP6 inflammasome plays a central role in the maintenance of epithelial integrity and host defense against microbial infections in the intestine (PubMed:30392956). Required to restrict infection against Gram-positive bacteria by recognizing lipoteichoic acid (LTA), leading to recruitment of CASP4 and CASP1, and subsequent maturation and secretion of IL1B and IL18 (PubMed:30392956, PubMed:33377178). Involved in intestinal antiviral innate immunity together with DHX15: recognizes and binds viral dsRNA to restrict infection by enteric viruses through the interferon pathway and GSDMD-dependent release of IL18 (PubMed:34678144, PubMed:34161762). Required to prevent infection by the apicomplexan parasite Cryptosporidium in enterocytes by promoting GSDMD-dependent release of IL18 (By similarity). The NLRP6 inflammasome may also regulate the gut microbiota composition by acting as a sensor of microbiota-associated metabolites to form a PYCARD/ASC-dependent inflammasome for downstream IL18 release and secretion of antimicrobial peptides (By similarity). Essential for gut mucosal self-renewal and proliferation (By similarity). Regulate mucus secretion in an inflammasome- and autophagy-dependent manner to prevent invasion by enteric bacteria, (By similarity). During systemic bacterial infections, the NLRP6 inflammasome negatively regulates neutrophil recruitment and neutrophil extracellular traps (NETs) formation (By similarity). May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity). {ECO:0000250|UniProtKB:Q91WS2, ECO:0000269|PubMed:12387869, ECO:0000269|PubMed:30392956, ECO:0000269|PubMed:30674671, ECO:0000269|PubMed:31932628, ECO:0000269|PubMed:33377178, ECO:0000269|PubMed:34161762, ECO:0000269|PubMed:34678144}.		acute inflammatory response [GO:0002526]; acute inflammatory response to antigenic stimulus [GO:0002438]; antiviral innate immune response [GO:0140374]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; necroptotic process [GO:0070266]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of type II interferon production [GO:0032689]; neutrophil-mediated killing of gram-positive bacterium [GO:0070946]; NLRP6 inflammasome complex assembly [GO:0140739]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-18-mediated signaling pathway [GO:2000494]; protein homooligomerization [GO:0051260]; pyroptosis [GO:0070269]; regulation of autophagy [GO:0010506]; regulation of inflammatory response [GO:0050727]; regulation of mucus secretion [GO:0070255]; response to bacterium [GO:0009617]; wound healing [GO:0042060]	canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP6 inflammasome complex [GO:0140738]; non-membrane-bounded organelle [GO:0043228]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; molecular condensate scaffold activity [GO:0140693]; pattern recognition receptor activity [GO:0038187]; peptide binding [GO:0042277]; signaling adaptor activity [GO:0035591]; vasopressin receptor activity [GO:0005000]	canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP6 inflammasome complex [GO:0140738]; non-membrane-bounded organelle [GO:0043228]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; molecular condensate scaffold activity [GO:0140693]; pattern recognition receptor activity [GO:0038187]; peptide binding [GO:0042277]; signaling adaptor activity [GO:0035591]; vasopressin receptor activity [GO:0005000]; acute inflammatory response [GO:0002526]; acute inflammatory response to antigenic stimulus [GO:0002438]; antiviral innate immune response [GO:0140374]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; necroptotic process [GO:0070266]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of type II interferon production [GO:0032689]; neutrophil-mediated killing of gram-positive bacterium [GO:0070946]; NLRP6 inflammasome complex assembly [GO:0140739]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-18-mediated signaling pathway [GO:2000494]; protein homooligomerization [GO:0051260]; pyroptosis [GO:0070269]; regulation of autophagy [GO:0010506]; regulation of inflammatory response [GO:0050727]; regulation of mucus secretion [GO:0070255]; response to bacterium [GO:0009617]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12387869, ECO:0000269|PubMed:31932628}. Inflammasome {ECO:0000269|PubMed:12387869, ECO:0000269|PubMed:30674671, ECO:0000269|PubMed:31932628, ECO:0000269|PubMed:34678144}. Cell membrane {ECO:0000250|UniProtKB:Q63035}. Nucleus membrane {ECO:0000250|UniProtKB:Q63035}.
P59046	reviewed	NAL12_HUMAN	NACHT, LRR and PYD domains-containing protein 12 (Monarch-1) (PYRIN-containing APAF1-like protein 7) (Regulated by nitric oxide)	NLRP12 NALP12 PYPAF7 RNO	Homo sapiens (Human)	1061	FUNCTION: Plays an essential role as an potent mitigator of inflammation (PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, PubMed:17947705). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Inhibits also the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation (PubMed:30902577). Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity). {ECO:0000250|UniProtKB:E9Q5R7, ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17947705, ECO:0000269|PubMed:30559449, ECO:0000269|PubMed:30902577}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cellular response to cytokine stimulus [GO:0071345]; dendritic cell migration [GO:0036336]; ERK1 and ERK2 cascade [GO:0070371]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of signal transduction [GO:0009968]; negative regulation of Toll signaling pathway [GO:0045751]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of interleukin-18 production [GO:0032661]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cellular response to cytokine stimulus [GO:0071345]; dendritic cell migration [GO:0036336]; ERK1 and ERK2 cascade [GO:0070371]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of signal transduction [GO:0009968]; negative regulation of Toll signaling pathway [GO:0045751]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of interleukin-18 production [GO:0032661]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30902577}.
P59047	reviewed	NALP5_HUMAN	NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog) (Maternal Antigen that Embryos Require)	NLRP5 MATER NALP5	Homo sapiens (Human)	1200	FUNCTION: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum (ER) storage via regulation of ER localization (By similarity). May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (By similarity). {ECO:0000250|UniProtKB:Q9R1M5}.		actin filament organization [GO:0007015]; cortical granule exocytosis [GO:0060471]; establishment of organelle localization [GO:0051656]; establishment of spindle localization [GO:0051293]; exocytosis [GO:0006887]; positive regulation of embryonic development [GO:0040019]; regulation of cell division [GO:0051302]; regulation of inflammatory response [GO:0050727]; regulation of localization [GO:0032879]	cell cortex [GO:0005938]; cortical granule [GO:0060473]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; subcortical maternal complex [GO:0106333]	ATP binding [GO:0005524]; tubulin binding [GO:0015631]	cell cortex [GO:0005938]; cortical granule [GO:0060473]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; subcortical maternal complex [GO:0106333]; ATP binding [GO:0005524]; tubulin binding [GO:0015631]; actin filament organization [GO:0007015]; cortical granule exocytosis [GO:0060471]; establishment of organelle localization [GO:0051656]; establishment of spindle localization [GO:0051293]; exocytosis [GO:0006887]; positive regulation of embryonic development [GO:0040019]; regulation of cell division [GO:0051302]; regulation of inflammatory response [GO:0050727]; regulation of localization [GO:0032879]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000269|PubMed:19192343}. Mitochondrion {ECO:0000269|PubMed:19192343}. Nucleus, nucleolus {ECO:0000269|PubMed:19192343, ECO:0000269|PubMed:25542835}. Cytoplasm {ECO:0000269|PubMed:19192343, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:25542835}. Golgi apparatus {ECO:0000269|PubMed:19192343}.
P59103	reviewed	DAOA_HUMAN	D-amino acid oxidase activator (Protein G72)	DAOA G72	Homo sapiens (Human)	153	FUNCTION: Seems to activate D-amino acid oxidase.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	negative regulation of D-amino-acid oxidase activity [GO:1900758]; positive regulation of catalytic activity [GO:0043085]	Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]	enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]	Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; negative regulation of D-amino-acid oxidase activity [GO:1900758]; positive regulation of catalytic activity [GO:0043085]	SUBCELLULAR LOCATION: Golgi apparatus.
P59190	reviewed	RAB15_HUMAN	Ras-related protein Rab-15	RAB15	Homo sapiens (Human)	212	FUNCTION: May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal. {ECO:0000250}.		positive regulation of regulated secretory pathway [GO:1903307]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]	cilium [GO:0005929]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cilium [GO:0005929]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; positive regulation of regulated secretory pathway [GO:1903307]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P59510	reviewed	ATS20_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAM-TS 20) (ADAM-TS20) (ADAMTS-20) (EC 3.4.24.-)	ADAMTS20	Homo sapiens (Human)	1910	FUNCTION: May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.		apoptotic process [GO:0006915]; extracellular matrix organization [GO:0030198]; melanocyte differentiation [GO:0030318]; negative regulation of apoptotic process [GO:0043066]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of signal transduction [GO:0009967]; proteolysis [GO:0006508]; signal transduction [GO:0007165]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; extracellular matrix organization [GO:0030198]; melanocyte differentiation [GO:0030318]; negative regulation of apoptotic process [GO:0043066]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of signal transduction [GO:0009967]; proteolysis [GO:0006508]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
P59538	reviewed	T2R31_HUMAN	Taste receptor type 2 member 31 (T2R31) (Taste receptor type 2 member 44) (T2R44) (Taste receptor type 2 member 53) (T2R53)	TAS2R31 TAS2R44	Homo sapiens (Human)	309	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P59542	reviewed	T2R19_HUMAN	Taste receptor type 2 member 19 (Taste receptor type 2 member 23) (Taste receptor type 2 member 48) (T2R48)	TAS2R19 TAS2R23 TAS2R48	Homo sapiens (Human)	299	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	sensory perception of taste [GO:0050909]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; sensory perception of taste [GO:0050909]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P59665	reviewed	DEF1_HUMAN	Neutrophil defensin 1 (Defensin, alpha 1) (HNP-1) (HP-1) (HP1) [Cleaved into: HP 1-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]	DEFA1 DEF1 DEFA2 MRS; DEFA1B	Homo sapiens (Human)	94	FUNCTION: Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs (PubMed:15616305, PubMed:17142766, PubMed:20220136, PubMed:24236072). Interacts with the essential precursor of cell wall synthesis lipid II to inhibit bacterial cell wall synthesis (PubMed:20214904). Inhibits adenovirus infection via inhibition of viral disassembly at the vertex region, thereby restricting the release of internal capsid protein pVI, which is required for endosomal membrane penetration during cell entry (PubMed:18191790). In addition, interaction with adenovirus capsid leads to the redirection of viral particles to TLR4 thereby promoting a NLRP3-mediated inflammasome response and interleukin 1-beta (IL-1beta) release (PubMed:35080426). Induces the production of proinflammatory cytokines including type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by triggering the degradation of NFKBIA and nuclear translocation of IRF1, both of which are required for activation of pDCs (PubMed:27031443). {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:17142766, ECO:0000269|PubMed:17452329, ECO:0000269|PubMed:18191790, ECO:0000269|PubMed:20214904, ECO:0000269|PubMed:20220136, ECO:0000269|PubMed:24236072, ECO:0000269|PubMed:27031443, ECO:0000269|PubMed:35080426}.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemotaxis [GO:0006935]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response [GO:0006955]; innate immune response in mucosa [GO:0002227]; intracellular estrogen receptor signaling pathway [GO:0030520]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]; perturbation of plasma membrane integrity in another organism [GO:0051673]; T cell chemotaxis [GO:0010818]	azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]	pore-forming activity [GO:0140911]	azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; pore-forming activity [GO:0140911]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemotaxis [GO:0006935]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response [GO:0006955]; innate immune response in mucosa [GO:0002227]; intracellular estrogen receptor signaling pathway [GO:0030520]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]; perturbation of plasma membrane integrity in another organism [GO:0051673]; T cell chemotaxis [GO:0010818]	SUBCELLULAR LOCATION: Secreted.
P59666	reviewed	DEF3_HUMAN	Neutrophil defensin 3 (Defensin, alpha 3) (HNP-3) (HP-3) (HP3) [Cleaved into: HP 3-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]	DEFA3 DEF3	Homo sapiens (Human)	94	FUNCTION: Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed:15616305, PubMed:15772169, PubMed:17142766). Possesses the ability to neutralize bacterial toxins such as B. anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus (PubMed:15772169, PubMed:18435932, PubMed:25963798). Blocks also herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment (PubMed:17142766). {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:15772169, ECO:0000269|PubMed:15894545, ECO:0000269|PubMed:17142766, ECO:0000269|PubMed:17452329, ECO:0000269|PubMed:18435932, ECO:0000269|PubMed:2006422, ECO:0000269|PubMed:25963798}.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; innate immune response in mucosa [GO:0002227]; intracellular estrogen receptor signaling pathway [GO:0030520]; killing of cells of another organism [GO:0031640]; perturbation of plasma membrane integrity in another organism [GO:0051673]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]	protein homodimerization activity [GO:0042803]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; protein homodimerization activity [GO:0042803]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; innate immune response in mucosa [GO:0002227]; intracellular estrogen receptor signaling pathway [GO:0030520]; killing of cells of another organism [GO:0031640]; perturbation of plasma membrane integrity in another organism [GO:0051673]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29282039}.
P59773	reviewed	MNARL_HUMAN	Major intrinsically disordered NOTCH2-binding receptor 1-like (Major intrinsically disordered NOTCH2-associated receptor 2) (Membrane integral NOTCH2-associated receptor 2)	MINAR2 KIAA1024L	Homo sapiens (Human)	190	FUNCTION: Binds cholesterol and may regulate the distribution and homeostasis of cholesterol in hair cells (PubMed:36317962). May play a role in angiogenesis (PubMed:35727972). {ECO:0000269|PubMed:35727972, ECO:0000269|PubMed:36317962}.		angiogenesis [GO:0001525]; cholesterol homeostasis [GO:0042632]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]	cholesterol binding [GO:0015485]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; cholesterol binding [GO:0015485]; angiogenesis [GO:0001525]; cholesterol homeostasis [GO:0042632]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:F1QEA1}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:32954300}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to the stereocilia and the apical region of hair cell, apparently around and just below the cuticular plate (By similarity). Co-localized with cholesterol in the stereocilia (By similarity). {ECO:0000250|UniProtKB:F1QEA1}.
P59780	reviewed	AP3S2_HUMAN	AP-3 complex subunit sigma-2 (AP-3 complex subunit sigma-3B) (Adaptor-related protein complex 3 subunit sigma-2) (Sigma-3B-adaptin) (Sigma3B-adaptin) (Sigma-adaptin 3b)	AP3S2	Homo sapiens (Human)	193	FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.		anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]	AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; presynapse [GO:0098793]		AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; presynapse [GO:0098793]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
P59817	reviewed	Z280A_HUMAN	Zinc finger protein 280A (3'OY11.1) (Suppressor of hairy wing homolog 1) (Zinc finger protein 636)	ZNF280A SUHW1 ZNF280 ZNF636	Homo sapiens (Human)	542	FUNCTION: May function as a transcription factor.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P59827	reviewed	BPIB4_HUMAN	BPI fold-containing family B member 4 (Ligand-binding protein RY2G5) (Long palate, lung and nasal epithelium carcinoma-associated protein 4)	BPIFB4 C20orf186 LPLUNC4	Homo sapiens (Human)	614	FUNCTION: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity). {ECO:0000250}.			actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular region [GO:0005576]	lipid binding [GO:0008289]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular region [GO:0005576]; lipid binding [GO:0008289]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12837268}.
P59901	reviewed	LIRA4_HUMAN	Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85 antigen-like family member G) (Immunoglobulin-like transcript 7) (ILT-7) (CD antigen CD85g)	LILRA4 ILT7	Homo sapiens (Human)	499	FUNCTION: Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760). {ECO:0000269|PubMed:16735691, ECO:0000269|PubMed:19564354, ECO:0000269|PubMed:24586760, ECO:0000269|PubMed:26172439}.		cytokine-mediated signaling pathway [GO:0019221]; Fc-epsilon receptor signaling pathway [GO:0038095]; innate immune response [GO:0045087]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of toll-like receptor 7 signaling pathway [GO:0034156]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; negative regulation of tumor necrosis factor production [GO:0032720]	Fc-epsilon receptor I complex [GO:0032998]; plasma membrane [GO:0005886]	coreceptor activity [GO:0015026]; inhibitory MHC class I receptor activity [GO:0032396]; signaling receptor binding [GO:0005102]	Fc-epsilon receptor I complex [GO:0032998]; plasma membrane [GO:0005886]; coreceptor activity [GO:0015026]; inhibitory MHC class I receptor activity [GO:0032396]; signaling receptor binding [GO:0005102]; cytokine-mediated signaling pathway [GO:0019221]; Fc-epsilon receptor signaling pathway [GO:0038095]; innate immune response [GO:0045087]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of toll-like receptor 7 signaling pathway [GO:0034156]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; negative regulation of tumor necrosis factor production [GO:0032720]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16735691, ECO:0000269|PubMed:19564354, ECO:0000269|PubMed:24586760, ECO:0000269|PubMed:26172439}; Single-pass type I membrane protein {ECO:0000305|PubMed:16735691, ECO:0000305|PubMed:19564354, ECO:0000305|PubMed:24586760, ECO:0000305|PubMed:26172439}.
P59910	reviewed	DJB13_HUMAN	DnaJ homolog subfamily B member 13 (Testis and spermatogenesis cell-related protein 6) (Testis spermatocyte apoptosis-related gene 6 protein) (Testis spermatogenesis apoptosis-related gene 3 protein) (Testis spermatogenesis apoptosis-related gene 6 protein)	DNAJB13 TSARG3 TSARG6	Homo sapiens (Human)	316	FUNCTION: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. {ECO:0000269|PubMed:27486783}.		axonemal central apparatus assembly [GO:1904158]; chaperone cofactor-dependent protein refolding [GO:0051085]	axoneme [GO:0005930]; cytosol [GO:0005829]; motile cilium [GO:0031514]; sperm connecting piece [GO:0097224]; sperm flagellum [GO:0036126]	protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	axoneme [GO:0005930]; cytosol [GO:0005829]; motile cilium [GO:0031514]; sperm connecting piece [GO:0097224]; sperm flagellum [GO:0036126]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; axonemal central apparatus assembly [GO:1904158]; chaperone cofactor-dependent protein refolding [GO:0051085]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:27486783}. Note=Localizes both to epithelial motile cilium and the sperm flagellum (PubMed:27486783). In spermatids, rapidly enriched in the coupling apparatus with the elongation of the spermatid. Tightly attached to the implantation fossa during the maturation of the spermatid. In mature spermatzoa evenly distributed along the flagellum (By similarity). {ECO:0000250|UniProtKB:Q80Y75, ECO:0000269|PubMed:27486783}.
P59923	reviewed	ZN445_HUMAN	Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15)	ZNF445 ZFP445 ZKSCAN15 ZNF168	Homo sapiens (Human)	1031	FUNCTION: Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). {ECO:0000269|PubMed:30602440}.		epigenetic programing of female pronucleus [GO:0044726]; negative regulation of gene expression via CpG island methylation [GO:0044027]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; double-stranded methylated DNA binding [GO:0010385]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; double-stranded methylated DNA binding [GO:0010385]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; epigenetic programing of female pronucleus [GO:0044726]; negative regulation of gene expression via CpG island methylation [GO:0044027]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30602440}. Note=Binds various differentially methylated regions (DMR). {ECO:0000269|PubMed:30602440}.
P59942	reviewed	MCCD1_HUMAN	Mitochondrial coiled-coil domain protein 1	MCCD1	Homo sapiens (Human)	119				mitochondrion [GO:0005739]		mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14527716}.
P59990	reviewed	KR121_HUMAN	Keratin-associated protein 12-1 (High sulfur keratin-associated protein 12.1) (Keratin-associated protein 12.1)	KRTAP12-1 KAP12.1 KRTAP12.1	Homo sapiens (Human)	96	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P59991	reviewed	KR122_HUMAN	Keratin-associated protein 12-2 (High sulfur keratin-associated protein 12.2) (Keratin-associated protein 12.2)	KRTAP12-2 KAP12.2 KRTAP12.2	Homo sapiens (Human)	146	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P59998	reviewed	ARPC4_HUMAN	Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)	ARPC4 ARC20	Homo sapiens (Human)	168	FUNCTION: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.		actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; Arp2/3 complex-mediated actin nucleation [GO:0034314]	Arp2/3 protein complex [GO:0005885]; cell projection [GO:0042995]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	actin binding [GO:0003779]; enzyme binding [GO:0019899]; structural constituent of cytoskeleton [GO:0005200]	Arp2/3 protein complex [GO:0005885]; cell projection [GO:0042995]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; actin binding [GO:0003779]; enzyme binding [GO:0019899]; structural constituent of cytoskeleton [GO:0005200]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; Arp2/3 complex-mediated actin nucleation [GO:0034314]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9359840}. Cell projection {ECO:0000269|PubMed:9359840}. Nucleus {ECO:0000269|PubMed:29925947}.
P60006	reviewed	APC15_HUMAN	Anaphase-promoting complex subunit 15 (APC15)	ANAPC15 C11orf51 HSPC020	Homo sapiens (Human)	121	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20. {ECO:0000269|PubMed:21926987}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]		anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	
P60008	reviewed	HILS1_HUMAN	Putative spermatid-specific linker histone H1-like protein (H1.9 linker histone pseudogene)	H1-9P H1-9 HILS1	Homo sapiens (Human)	231	FUNCTION: DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa. {ECO:0000250|UniProtKB:Q9QYL0}.		chromatin remodeling [GO:0006338]; chromosome condensation [GO:0030261]; germ cell development [GO:0007281]; heterochromatin formation [GO:0031507]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283]	male germ cell nucleus [GO:0001673]; nucleosome [GO:0000786]; nucleus [GO:0005634]	double-stranded DNA binding [GO:0003690]; histone binding [GO:0042393]; nucleic acid binding [GO:0003676]; nucleosomal DNA binding [GO:0031492]	male germ cell nucleus [GO:0001673]; nucleosome [GO:0000786]; nucleus [GO:0005634]; double-stranded DNA binding [GO:0003690]; histone binding [GO:0042393]; nucleic acid binding [GO:0003676]; nucleosomal DNA binding [GO:0031492]; chromatin remodeling [GO:0006338]; chromosome condensation [GO:0030261]; germ cell development [GO:0007281]; heterochromatin formation [GO:0031507]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837}.
P60014	reviewed	KR10A_HUMAN	Keratin-associated protein 10-10 (High sulfur keratin-associated protein 10.10) (Keratin-associated protein 10.10) (Keratin-associated protein 18-10) (Keratin-associated protein 18.10)	KRTAP10-10 KAP10.10 KAP18-10 KRTAP10.10 KRTAP18-1 KRTAP18.10	Homo sapiens (Human)	251	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P60022	reviewed	DEFB1_HUMAN	Beta-defensin 1 (BD-1) (hBD-1) (Defensin, beta 1)	DEFB1 BD1 HBD1	Homo sapiens (Human)	68	FUNCTION: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). {ECO:0000269|PubMed:25122636}.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cAMP-mediated signaling [GO:0019933]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; positive regulation of flagellated sperm motility involved in capacitation [GO:0060474]; response to bacterium [GO:0009617]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; microvesicle [GO:1990742]; sperm midpiece [GO:0097225]	CCR6 chemokine receptor binding [GO:0031731]; identical protein binding [GO:0042802]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; microvesicle [GO:1990742]; sperm midpiece [GO:0097225]; CCR6 chemokine receptor binding [GO:0031731]; identical protein binding [GO:0042802]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cAMP-mediated signaling [GO:0019933]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; positive regulation of flagellated sperm motility involved in capacitation [GO:0060474]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7628632}. Membrane {ECO:0000269|PubMed:23938203}. Note=Associates with tumor cell membrane-derived microvesicles (PubMed:23938203). {ECO:0000269|PubMed:23938203}.
P60033	reviewed	CD81_HUMAN	CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)	CD81 TAPA1 TSPAN28	Homo sapiens (Human)	236	FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells (PubMed:20237408, PubMed:27881302, PubMed:16449649). Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production (PubMed:15161911, PubMed:20237408). In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype (PubMed:22307619, PubMed:23858057, PubMed:8766544). Present in MHC class II compartments, may also play a role in antigen presentation (PubMed:8409388, PubMed:8766544). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction (By similarity). In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480). Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (PubMed:28871089). Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity). {ECO:0000250|UniProtKB:P35762, ECO:0000269|PubMed:12796480, ECO:0000269|PubMed:15161911, ECO:0000269|PubMed:16449649, ECO:0000269|PubMed:20237408, ECO:0000269|PubMed:22307619, ECO:0000269|PubMed:23858057, ECO:0000269|PubMed:27881302, ECO:0000269|PubMed:28871089, ECO:0000269|PubMed:8409388, ECO:0000269|PubMed:8766544}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Association with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. {ECO:0000269|PubMed:20375010, ECO:0000269|PubMed:21516087, ECO:0000269|PubMed:26116703, ECO:0000269|PubMed:26354436}.; FUNCTION: (Microbial infection) Involved in SAMHD1-dependent restriction of HIV-1 replication. May support early replication of both R5- and X4-tropic HIV-1 viruses in T cells, likely via proteasome-dependent degradation of SAMHD1. {ECO:0000269|PubMed:28871089}.; FUNCTION: (Microbial infection) Specifically required for Plasmodium falciparum infectivity of hepatocytes, controlling sporozoite entry into hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms. {ECO:0000269|PubMed:12483205}.		CD4-positive, alpha-beta T cell costimulation [GO:0035783]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; immunological synapse formation [GO:0001771]; macrophage fusion [GO:0034238]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; osteoclast fusion [GO:0072675]; positive regulation of adaptive immune memory response [GO:1905676]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein catabolic process in the vacuole [GO:1904352]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of receptor clustering [GO:1903911]; positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001190]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to lysosome [GO:0061462]; protein localization to plasma membrane [GO:0072659]; receptor internalization [GO:0031623]; regulation of macrophage migration [GO:1905521]; regulation of protein stability [GO:0031647]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197]; vesicle [GO:0031982]	cholesterol binding [GO:0015485]; integrin binding [GO:0005178]; MHC class II protein binding [GO:0042289]; MHC class II protein complex binding [GO:0023026]; transferrin receptor binding [GO:1990459]; virus receptor activity [GO:0001618]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197]; vesicle [GO:0031982]; cholesterol binding [GO:0015485]; integrin binding [GO:0005178]; MHC class II protein binding [GO:0042289]; MHC class II protein complex binding [GO:0023026]; transferrin receptor binding [GO:1990459]; virus receptor activity [GO:0001618]; CD4-positive, alpha-beta T cell costimulation [GO:0035783]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; immunological synapse formation [GO:0001771]; macrophage fusion [GO:0034238]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; osteoclast fusion [GO:0072675]; positive regulation of adaptive immune memory response [GO:1905676]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein catabolic process in the vacuole [GO:1904352]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of receptor clustering [GO:1903911]; positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001190]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to lysosome [GO:0061462]; protein localization to plasma membrane [GO:0072659]; receptor internalization [GO:0031623]; regulation of macrophage migration [GO:1905521]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:1695320, ECO:0000269|PubMed:20237408, ECO:0000269|PubMed:22307619, ECO:0000269|PubMed:2398277, ECO:0000269|PubMed:26354436}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}. Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. {ECO:0000269|PubMed:20375010}.
P60059	reviewed	SC61G_HUMAN	Protein transport protein Sec61 subunit gamma	SEC61G	Homo sapiens (Human)	68	FUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). {ECO:0000250|UniProtKB:P60058, ECO:0000250|UniProtKB:P61619, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.		post-translational protein targeting to membrane, translocation [GO:0031204]; protein targeting to ER [GO:0045047]	cytosol [GO:0005829]; membrane [GO:0016020]; Ssh1 translocon complex [GO:0071261]	protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022]	cytosol [GO:0005829]; membrane [GO:0016020]; Ssh1 translocon complex [GO:0071261]; protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022]; post-translational protein targeting to membrane, translocation [GO:0031204]; protein targeting to ER [GO:0045047]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:36261522}; Single-pass membrane protein {ECO:0000255}.
P60174	reviewed	TPIS_HUMAN	Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase)	TPI1 TPI	Homo sapiens (Human)	249	FUNCTION: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}.	MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing. {ECO:0000305}.	canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; glycerol catabolic process [GO:0019563]; glycolytic process [GO:0006096]; methylglyoxal biosynthetic process [GO:0019242]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]	methylglyoxal synthase activity [GO:0008929]; protein homodimerization activity [GO:0042803]; triose-phosphate isomerase activity [GO:0004807]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]; methylglyoxal synthase activity [GO:0008929]; protein homodimerization activity [GO:0042803]; triose-phosphate isomerase activity [GO:0004807]; ubiquitin protein ligase binding [GO:0031625]; canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; glycerol catabolic process [GO:0019563]; glycolytic process [GO:0006096]; methylglyoxal biosynthetic process [GO:0019242]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU10127}.
P60201	reviewed	MYPR_HUMAN	Myelin proteolipid protein (PLP) (Lipophilin)	PLP1 PLP	Homo sapiens (Human)	277	FUNCTION: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.		AMPA selective glutamate receptor signaling pathway [GO:0098990]; astrocyte development [GO:0014002]; axon development [GO:0061564]; axon ensheathment [GO:0008366]; central nervous system myelination [GO:0022010]; chemical synaptic transmission [GO:0007268]; inflammatory response [GO:0006954]; long-chain fatty acid biosynthetic process [GO:0042759]; positive regulation of calcium ion transmembrane transport [GO:1904427]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; substantia nigra development [GO:0021762]	integrin alphav-beta3 complex [GO:0034683]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; synapse [GO:0045202]	identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; structural constituent of myelin sheath [GO:0019911]; structural molecule activity [GO:0005198]	integrin alphav-beta3 complex [GO:0034683]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; synapse [GO:0045202]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; structural constituent of myelin sheath [GO:0019911]; structural molecule activity [GO:0005198]; AMPA selective glutamate receptor signaling pathway [GO:0098990]; astrocyte development [GO:0014002]; axon development [GO:0061564]; axon ensheathment [GO:0008366]; central nervous system myelination [GO:0022010]; chemical synaptic transmission [GO:0007268]; inflammatory response [GO:0006954]; long-chain fatty acid biosynthetic process [GO:0042759]; positive regulation of calcium ion transmembrane transport [GO:1904427]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24103481}; Multi-pass membrane protein {ECO:0000269|PubMed:24103481}. Myelin membrane {ECO:0000250}. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat. {ECO:0000250}.
P60228	reviewed	EIF3E_HUMAN	Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48)	EIF3E EIF3S6 INT6	Homo sapiens (Human)	445	FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924). {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMed:17468741, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.		formation of cytoplasmic translation initiation complex [GO:0001732]; negative regulation of translational initiation [GO:0045947]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; postsynaptic density [GO:0014069]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; postsynaptic density [GO:0014069]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; formation of cytoplasmic translation initiation complex [GO:0001732]; negative regulation of translational initiation [GO:0045947]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, PML body.
P60321	reviewed	NANO2_HUMAN	Nanos homolog 2 (NOS-2)	NANOS2 NOS2	Homo sapiens (Human)	138	FUNCTION: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity). {ECO:0000250}.		germ-line stem cell population maintenance [GO:0030718]; mRNA catabolic process [GO:0006402]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of translation [GO:0017148]; oogenesis [GO:0048477]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]	mRNA binding [GO:0003729]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; mRNA binding [GO:0003729]; zinc ion binding [GO:0008270]; germ-line stem cell population maintenance [GO:0030718]; mRNA catabolic process [GO:0006402]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of translation [GO:0017148]; oogenesis [GO:0048477]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19168545}. Cytoplasm, P-body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19168545}. Note=Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. {ECO:0000250}.
P60323	reviewed	NANO3_HUMAN	Nanos homolog 3 (NOS-3)	NANOS3 NOS3	Homo sapiens (Human)	173	FUNCTION: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. {ECO:0000269|PubMed:21421998}.		apoptotic signaling pathway [GO:0097190]; germ cell development [GO:0007281]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of translation [GO:0017148]; oogenesis [GO:0048477]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; regulation of cell cycle [GO:0051726]; regulation of translation [GO:0006417]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; apoptotic signaling pathway [GO:0097190]; germ cell development [GO:0007281]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of translation [GO:0017148]; oogenesis [GO:0048477]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; regulation of cell cycle [GO:0051726]; regulation of translation [GO:0006417]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21421998}. Cytoplasm {ECO:0000269|PubMed:21421998}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P60324}. Cytoplasm, P-body {ECO:0000250|UniProtKB:P60324}. Note=Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body. {ECO:0000250|UniProtKB:P60324}.
P60328	reviewed	KR123_HUMAN	Keratin-associated protein 12-3 (High sulfur keratin-associated protein 12.3) (Keratin-associated protein 12.3)	KRTAP12-3 KAP12.3 KRTAP12.3	Homo sapiens (Human)	96	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; keratin filament [GO:0045095]; identical protein binding [GO:0042802]	
P60329	reviewed	KR124_HUMAN	Keratin-associated protein 12-4 (High sulfur keratin-associated protein 12.4) (Keratin-associated protein 12.4)	KRTAP12-4 KAP12.4 KRTAP12.4	Homo sapiens (Human)	112	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
P60368	reviewed	KR102_HUMAN	Keratin-associated protein 10-2 (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2)	KRTAP10-2 KAP10.2 KAP18-2 KRTAP10.2 KRTAP18-2 KRTAP18.2	Homo sapiens (Human)	255	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P60370	reviewed	KR105_HUMAN	Keratin-associated protein 10-5 (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5)	KRTAP10-5 KAP10.5 KAP18-5 KRTAP10.5 KRTAP18-5 KRTAP18.5	Homo sapiens (Human)	271	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; keratin filament [GO:0045095]; identical protein binding [GO:0042802]	
P60371	reviewed	KR106_HUMAN	Keratin-associated protein 10-6 (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6)	KRTAP10-6 KAP10.6 KAP18-6 KRTAP10.6 KRTAP18-6 KRTAP18.6	Homo sapiens (Human)	365	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P60372	reviewed	KR104_HUMAN	Keratin-associated protein 10-4 (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4)	KRTAP10-4 KAP10.4 KAP18-4 KRTAP10.4 KRTAP18-4 KRTAP18.4	Homo sapiens (Human)	401	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P60409	reviewed	KR107_HUMAN	Keratin-associated protein 10-7 (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7)	KRTAP10-7 KAP10.7 KAP18-7 KRTAP10.7 KRTAP18-7 KRTAP18.7	Homo sapiens (Human)	370	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; keratin filament [GO:0045095]; identical protein binding [GO:0042802]	
P60410	reviewed	KR108_HUMAN	Keratin-associated protein 10-8 (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8)	KRTAP10-8 KAP10.8 KAP18-8 KRTAP10.8 KRTAP18-8 KRTAP18.8	Homo sapiens (Human)	259	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; keratin filament [GO:0045095]; identical protein binding [GO:0042802]	
P60411	reviewed	KR109_HUMAN	Keratin-associated protein 10-9 (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9)	KRTAP10-9 KAP10.9 KAP18-9 KRTAP10.9 KRTAP18-9 KRTAP18.9	Homo sapiens (Human)	292	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P60412	reviewed	KR10B_HUMAN	Keratin-associated protein 10-11 (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11)	KRTAP10-11 KAP10.11 KAP18-11 KRTAP10.11 KRTAP18-11 KRTAP18.11	Homo sapiens (Human)	298	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P60468	reviewed	SC61B_HUMAN	Protein transport protein Sec61 subunit beta	SEC61B	Homo sapiens (Human)	96	FUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:12475939). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:19121997). {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:19121997, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.		post-translational protein targeting to membrane, translocation [GO:0031204]; retrograde protein transport, ER to cytosol [GO:0030970]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; endoplasmic reticulum Sec complex [GO:0031205]; membrane [GO:0016020]; Sec61 translocon complex [GO:0005784]	epidermal growth factor binding [GO:0048408]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; endoplasmic reticulum Sec complex [GO:0031205]; membrane [GO:0016020]; Sec61 translocon complex [GO:0005784]; epidermal growth factor binding [GO:0048408]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; post-translational protein targeting to membrane, translocation [GO:0031204]; retrograde protein transport, ER to cytosol [GO:0030970]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:27044890}; Single-pass membrane protein {ECO:0000255}.
P60484	reviewed	PTEN_HUMAN	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)	PTEN MMAC1 TEP1	Homo sapiens (Human)	403	FUNCTION: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:16824732, PubMed:26504226, PubMed:9593664). Tumor suppressor, the lipid phosphatase activity is critical for its tumor suppressor function (PubMed:9187108, PubMed:9616126, PubMed:9811831). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}.	MISCELLANEOUS: [Isoform alpha]: Produced by alternative initiation at a CTG start codon of isoform 1. May contain a signal peptide at positions 1-21. {ECO:0000305}.	apoptotic process [GO:0006915]; brain morphogenesis [GO:0048854]; canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; cell motility [GO:0048870]; cellular response to electrical stimulus [GO:0071257]; central nervous system development [GO:0007417]; central nervous system myelin maintenance [GO:0032286]; central nervous system neuron axonogenesis [GO:0021955]; dendritic spine morphogenesis [GO:0060997]; dentate gyrus development [GO:0021542]; forebrain morphogenesis [GO:0048853]; heart development [GO:0007507]; learning or memory [GO:0007611]; localization [GO:0051179]; locomotor rhythm [GO:0045475]; locomotory behavior [GO:0007626]; multicellular organismal response to stress [GO:0033555]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of cellular senescence [GO:2000773]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of keratinocyte migration [GO:0051548]; negative regulation of neuron projection development [GO:0010977]; negative regulation of organ growth [GO:0046621]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of synaptic vesicle clustering [GO:2000808]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; neuron-neuron synaptic transmission [GO:0007270]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of TRAIL-activated apoptotic signaling pathway [GO:1903984]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; postsynaptic density assembly [GO:0097107]; prepulse inhibition [GO:0060134]; presynaptic membrane assembly [GO:0097105]; protein dephosphorylation [GO:0006470]; protein stabilization [GO:0050821]; regulation of cellular component size [GO:0032535]; regulation of neuron projection development [GO:0010975]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of protein stability [GO:0031647]; rhythmic synaptic transmission [GO:0060024]; social behavior [GO:0035176]; spindle assembly involved in female meiosis [GO:0007056]; synapse assembly [GO:0007416]; synapse maturation [GO:0060074]	apical plasma membrane [GO:0016324]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; myelin sheath adaxonal region [GO:0035749]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic density [GO:0014069]; Schmidt-Lanterman incisure [GO:0043220]	anaphase-promoting complex binding [GO:0010997]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [GO:0051717]; lipid binding [GO:0008289]; molecular function inhibitor activity [GO:0140678]; myosin phosphatase activity [GO:0017018]; PDZ domain binding [GO:0030165]; phosphatidylinositol phosphate phosphatase activity [GO:0052866]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [GO:0051800]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; ubiquitin-specific protease binding [GO:1990381]	apical plasma membrane [GO:0016324]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; myelin sheath adaxonal region [GO:0035749]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic density [GO:0014069]; Schmidt-Lanterman incisure [GO:0043220]; anaphase-promoting complex binding [GO:0010997]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [GO:0051717]; lipid binding [GO:0008289]; molecular function inhibitor activity [GO:0140678]; myosin phosphatase activity [GO:0017018]; PDZ domain binding [GO:0030165]; phosphatidylinositol phosphate phosphatase activity [GO:0052866]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [GO:0051800]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; ubiquitin-specific protease binding [GO:1990381]; apoptotic process [GO:0006915]; brain morphogenesis [GO:0048854]; canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; cell motility [GO:0048870]; cellular response to electrical stimulus [GO:0071257]; central nervous system development [GO:0007417]; central nervous system myelin maintenance [GO:0032286]; central nervous system neuron axonogenesis [GO:0021955]; dendritic spine morphogenesis [GO:0060997]; dentate gyrus development [GO:0021542]; forebrain morphogenesis [GO:0048853]; heart development [GO:0007507]; learning or memory [GO:0007611]; localization [GO:0051179]; locomotor rhythm [GO:0045475]; locomotory behavior [GO:0007626]; multicellular organismal response to stress [GO:0033555]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of cellular senescence [GO:2000773]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of keratinocyte migration [GO:0051548]; negative regulation of neuron projection development [GO:0010977]; negative regulation of organ growth [GO:0046621]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of synaptic vesicle clustering [GO:2000808]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; neuron-neuron synaptic transmission [GO:0007270]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of TRAIL-activated apoptotic signaling pathway [GO:1903984]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; postsynaptic density assembly [GO:0097107]; prepulse inhibition [GO:0060134]; presynaptic membrane assembly [GO:0097105]; protein dephosphorylation [GO:0006470]; protein stabilization [GO:0050821]; regulation of cellular component size [GO:0032535]; regulation of neuron projection development [GO:0010975]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of protein stability [GO:0031647]; rhythmic synaptic transmission [GO:0060024]; social behavior [GO:0035176]; spindle assembly involved in female meiosis [GO:0007056]; synapse assembly [GO:0007416]; synapse maturation [GO:0060074]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959, ECO:0000269|PubMed:9187108}. Nucleus {ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959}. Nucleus, PML body {ECO:0000269|PubMed:18716620}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:O54857}. Postsynaptic density {ECO:0000250|UniProtKB:O54857}. Note=Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982). Associares with the postsynaptic density in response to NMDAR activation (By similarity). {ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982}.; SUBCELLULAR LOCATION: [Isoform alpha]: Secreted {ECO:0000269|PubMed:23744781, ECO:0000269|PubMed:24768297}. Note=May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif. {ECO:0000269|PubMed:23744781, ECO:0000269|PubMed:24768297}.
P60507	reviewed	EFC1_HUMAN	Endogenous retrovirus group FC1 Env polyprotein (Envelope polyprotein) (Fc1env) (HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein) (HERV-Fc1env) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERVFC1	Homo sapiens (Human)	584	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: Orthologs in P.troglodytes and G.gorilla (truncated).		plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Virion.; SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P60508	reviewed	SYCY2_HUMAN	Syncytin-2 (Endogenous retrovirus group FRD member 1) (Envelope polyprotein) (HERV-FRD) (HERV-FRD_6p24.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERVFRD-1 ERVFRDE1 UNQ6191/PRO20218	Homo sapiens (Human)	538	FUNCTION: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732). {ECO:0000269|PubMed:18988732}.; FUNCTION: Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139). {ECO:0000269|PubMed:14694139}.	MISCELLANEOUS: HERV-FRD subgenomic RNA has been observed.; MISCELLANEOUS: Ortholog in old-world and new-world monkeys, but not in prosimians.; MISCELLANEOUS: The human genome contains a high percentage of proviral-like elements, also called endogenous retroviruses (ERVs) that are the genomic traces of ancient infections of the germline by exogenous retroviruses. Although most of these elements are defective, some have conserved a functional envelope (env) gene, most probably diverted by the host for its benefit.	myoblast fusion [GO:0007520]; syncytium formation [GO:0006949]; syncytium formation by plasma membrane fusion [GO:0000768]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; myoblast fusion [GO:0007520]; syncytium formation [GO:0006949]; syncytium formation by plasma membrane fusion [GO:0000768]	SUBCELLULAR LOCATION: Virion {ECO:0000305}.; SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250|UniProtKB:Q9UQF0}.; SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
P60510	reviewed	PP4C_HUMAN	Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X)	PPP4C PPP4 PPX	Homo sapiens (Human)	307	FUNCTION: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. {ECO:0000250, ECO:0000269|PubMed:11698396, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:12934076, ECO:0000269|PubMed:1336397, ECO:0000269|PubMed:15805470, ECO:0000269|PubMed:18347064, ECO:0000269|PubMed:18487071, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:18758438, ECO:0000269|PubMed:20154705}.		double-strand break repair via homologous recombination [GO:0000724]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via homologous recombination [GO:0010569]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase 4 complex [GO:0030289]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; NF-kappaB-inducing kinase activity [GO:0004704]; protein serine/threonine phosphatase activity [GO:0004722]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase 4 complex [GO:0030289]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; NF-kappaB-inducing kinase activity [GO:0004704]; protein serine/threonine phosphatase activity [GO:0004722]; double-strand break repair via homologous recombination [GO:0000724]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via homologous recombination [GO:0010569]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
P60520	reviewed	GBRL2_HUMAN	Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)	GABARAPL2 FLC3A GEF2	Homo sapiens (Human)	117	FUNCTION: Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (PubMed:20418806, PubMed:23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295). {ECO:0000250|UniProtKB:P60519, ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; intra-Golgi vesicle-mediated transport [GO:0006891]; macroautophagy [GO:0016236]; negative regulation of proteasomal protein catabolic process [GO:1901799]; positive regulation of ATP-dependent activity [GO:0032781]; protein localization to endoplasmic reticulum [GO:0070972]; protein transport [GO:0015031]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	ATPase binding [GO:0051117]; beta-tubulin binding [GO:0048487]; GABA receptor binding [GO:0050811]; microtubule binding [GO:0008017]; phosphatidylethanolamine binding [GO:0008429]; SNARE binding [GO:0000149]; ubiquitin protein ligase binding [GO:0031625]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; ATPase binding [GO:0051117]; beta-tubulin binding [GO:0048487]; GABA receptor binding [GO:0050811]; microtubule binding [GO:0008017]; phosphatidylethanolamine binding [GO:0008429]; SNARE binding [GO:0000149]; ubiquitin protein ligase binding [GO:0031625]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; intra-Golgi vesicle-mediated transport [GO:0006891]; macroautophagy [GO:0016236]; negative regulation of proteasomal protein catabolic process [GO:1901799]; positive regulation of ATP-dependent activity [GO:0032781]; protein localization to endoplasmic reticulum [GO:0070972]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:12507496, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19056683, ECO:0000269|PubMed:22311637, ECO:0000269|PubMed:31709703}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30990354}. Golgi apparatus {ECO:0000250|UniProtKB:P60519}.
P60568	reviewed	IL2_HUMAN	Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)	IL2	Homo sapiens (Human)	153	FUNCTION: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:6438535). Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG) (PubMed:16293754, PubMed:16477002). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3 (PubMed:7973659). In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 (PubMed:8580378). This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways (PubMed:25142963). Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well (PubMed:6608729). Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production (PubMed:6438535). Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells. {ECO:0000269|PubMed:16293754, ECO:0000269|PubMed:16477002, ECO:0000269|PubMed:25142963, ECO:0000269|PubMed:6438535, ECO:0000269|PubMed:6608729, ECO:0000269|PubMed:7973659, ECO:0000269|PubMed:8580378}.		activated T cell proliferation [GO:0050798]; adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; immune response [GO:0006955]; interleukin-2-mediated signaling pathway [GO:0038110]; leukocyte activation involved in immune response [GO:0002366]; natural killer cell activation [GO:0030101]; negative regulation of apoptotic process [GO:0043066]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lymphocyte proliferation [GO:0050672]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000561]; regulation of T cell homeostatic proliferation [GO:0046013]; response to ethanol [GO:0045471]; response to tacrolimus [GO:1901327]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	carbohydrate binding [GO:0030246]; cytokine activity [GO:0005125]; glycosphingolipid binding [GO:0043208]; growth factor activity [GO:0008083]; interleukin-2 receptor binding [GO:0005134]; kappa-type opioid receptor binding [GO:0031851]; kinase activator activity [GO:0019209]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; carbohydrate binding [GO:0030246]; cytokine activity [GO:0005125]; glycosphingolipid binding [GO:0043208]; growth factor activity [GO:0008083]; interleukin-2 receptor binding [GO:0005134]; kappa-type opioid receptor binding [GO:0031851]; kinase activator activity [GO:0019209]; activated T cell proliferation [GO:0050798]; adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; immune response [GO:0006955]; interleukin-2-mediated signaling pathway [GO:0038110]; leukocyte activation involved in immune response [GO:0002366]; natural killer cell activation [GO:0030101]; negative regulation of apoptotic process [GO:0043066]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lymphocyte proliferation [GO:0050672]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000561]; regulation of T cell homeostatic proliferation [GO:0046013]; response to ethanol [GO:0045471]; response to tacrolimus [GO:1901327]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Secreted.
P60602	reviewed	ROMO1_HUMAN	Reactive oxygen species modulator 1 (ROS modulator 1) (Epididymis tissue protein Li 175) (Glyrichin) (Mitochondrial targeting GxxxG motif protein) (MTGM) (Protein MGR2 homolog)	ROMO1 C20orf52	Homo sapiens (Human)	79	FUNCTION: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.; FUNCTION: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.	MISCELLANEOUS: Enforced expression in IMR-90 cells leads to increased levels of ROS and induces premature cell senescence and nuclear DNA damage.	antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to reactive oxygen species [GO:0034614]; cytolysis by host of symbiont cells [GO:0051838]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; intracellular protein transport [GO:0006886]; killing of cells of another organism [GO:0031640]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial inner membrane [GO:0045039]; replicative senescence [GO:0090399]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to reactive oxygen species [GO:0034614]; cytolysis by host of symbiont cells [GO:0051838]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; intracellular protein transport [GO:0006886]; killing of cells of another organism [GO:0031640]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial inner membrane [GO:0045039]; replicative senescence [GO:0090399]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734}; Single-pass membrane protein {ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734}.
P60604	reviewed	UB2G2_HUMAN	Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)	UBE2G2 UBC7	Homo sapiens (Human)	165	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Involved in endoplasmic reticulum-associated degradation (ERAD) (PubMed:22607976). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation (PubMed:23223569). {ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23223569}.		cellular response to interferon-beta [GO:0035458]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to interferon-beta [GO:0035458]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:23223569}. Lipid droplet {ECO:0000269|PubMed:21127063, ECO:0000269|PubMed:23223569}.
P60660	reviewed	MYL6_HUMAN	Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6)	MYL6	Homo sapiens (Human)	151	FUNCTION: Regulatory light chain of myosin. Does not bind calcium.		muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle tissue development [GO:0007519]	brush border [GO:0005903]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; myosin complex [GO:0016459]; myosin II complex [GO:0016460]; unconventional myosin complex [GO:0016461]; vesicle [GO:0031982]	calcium ion binding [GO:0005509]; cytoskeletal motor activity [GO:0003774]; microfilament motor activity [GO:0000146]; structural constituent of muscle [GO:0008307]	brush border [GO:0005903]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; myosin complex [GO:0016459]; myosin II complex [GO:0016460]; unconventional myosin complex [GO:0016461]; vesicle [GO:0031982]; calcium ion binding [GO:0005509]; cytoskeletal motor activity [GO:0003774]; microfilament motor activity [GO:0000146]; structural constituent of muscle [GO:0008307]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle tissue development [GO:0007519]	
P60709	reviewed	ACTB_HUMAN	Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]	ACTB	Homo sapiens (Human)	375	FUNCTION: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947}.	MISCELLANEOUS: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. {ECO:0000305}.	adherens junction assembly [GO:0034333]; apical protein localization [GO:0045176]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; cellular response to cytochalasin B [GO:0072749]; chromatin remodeling [GO:0006338]; establishment or maintenance of cell polarity [GO:0007163]; maintenance of blood-brain barrier [GO:0035633]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of cell differentiation [GO:0045596]; negative regulation of protein binding [GO:0032091]; platelet aggregation [GO:0070527]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of norepinephrine uptake [GO:0051623]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; postsynaptic actin cytoskeleton organization [GO:0098974]; protein localization to adherens junction [GO:0071896]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of double-strand break repair [GO:2000779]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of norepinephrine uptake [GO:0051621]; regulation of nucleotide-excision repair [GO:2000819]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transepithelial transport [GO:0150111]; regulation of transmembrane transporter activity [GO:0022898]; retina homeostasis [GO:0001895]; substantia nigra development [GO:0021762]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; axon [GO:0030424]; bBAF complex [GO:0140092]; blood microparticle [GO:0072562]; brahma complex [GO:0035060]; brush border [GO:0005903]; calyx of Held [GO:0044305]; cell-cell junction [GO:0005911]; chromatin [GO:0000785]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dense body [GO:0097433]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; GBAF complex [GO:0140288]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic actin cytoskeleton [GO:0098871]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; RSC-type complex [GO:0016586]; Schaffer collateral - CA1 synapse [GO:0098685]; SWI/SNF complex [GO:0016514]; synapse [GO:0045202]; tight junction [GO:0070160]; vesicle [GO:0031982]	ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; nitric-oxide synthase binding [GO:0050998]; protein kinase binding [GO:0019901]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; Tat protein binding [GO:0030957]; tau protein binding [GO:0048156]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; axon [GO:0030424]; bBAF complex [GO:0140092]; blood microparticle [GO:0072562]; brahma complex [GO:0035060]; brush border [GO:0005903]; calyx of Held [GO:0044305]; cell-cell junction [GO:0005911]; chromatin [GO:0000785]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dense body [GO:0097433]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; GBAF complex [GO:0140288]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic actin cytoskeleton [GO:0098871]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; RSC-type complex [GO:0016586]; Schaffer collateral - CA1 synapse [GO:0098685]; SWI/SNF complex [GO:0016514]; synapse [GO:0045202]; tight junction [GO:0070160]; vesicle [GO:0031982]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; nitric-oxide synthase binding [GO:0050998]; protein kinase binding [GO:0019901]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; Tat protein binding [GO:0030957]; tau protein binding [GO:0048156]; adherens junction assembly [GO:0034333]; apical protein localization [GO:0045176]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; cellular response to cytochalasin B [GO:0072749]; chromatin remodeling [GO:0006338]; establishment or maintenance of cell polarity [GO:0007163]; maintenance of blood-brain barrier [GO:0035633]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of cell differentiation [GO:0045596]; negative regulation of protein binding [GO:0032091]; platelet aggregation [GO:0070527]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of norepinephrine uptake [GO:0051623]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; postsynaptic actin cytoskeleton organization [GO:0098974]; protein localization to adherens junction [GO:0071896]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of double-strand break repair [GO:2000779]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of norepinephrine uptake [GO:0051621]; regulation of nucleotide-excision repair [GO:2000819]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transepithelial transport [GO:0150111]; regulation of transmembrane transporter activity [GO:0022898]; retina homeostasis [GO:0001895]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:17289661}. Nucleus {ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:29925947}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:17289661}.
P60763	reviewed	RAC3_HUMAN	Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)	RAC3	Homo sapiens (Human)	192	FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. {ECO:0000269|PubMed:11756406, ECO:0000269|PubMed:11956649}.		actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cell chemotaxis [GO:0060326]; cell projection assembly [GO:0030031]; cerebral cortex GABAergic interneuron development [GO:0021894]; cortical cytoskeleton organization [GO:0030865]; engulfment of apoptotic cell [GO:0043652]; establishment or maintenance of cell polarity [GO:0007163]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular signal transduction [GO:0035556]; motor neuron axon guidance [GO:0008045]; neuromuscular process controlling balance [GO:0050885]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic actin cytoskeleton organization [GO:0098974]; Rac protein signal transduction [GO:0016601]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of neuron maturation [GO:0014041]; regulation of neutrophil migration [GO:1902622]; respiratory burst [GO:0045730]; synaptic transmission, GABAergic [GO:0051932]; Wnt signaling pathway [GO:0016055]	cell periphery [GO:0071944]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; NADPH oxidase complex [GO:0043020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	calcium-dependent protein binding [GO:0048306]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]	cell periphery [GO:0071944]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; NADPH oxidase complex [GO:0043020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium-dependent protein binding [GO:0048306]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cell chemotaxis [GO:0060326]; cell projection assembly [GO:0030031]; cerebral cortex GABAergic interneuron development [GO:0021894]; cortical cytoskeleton organization [GO:0030865]; engulfment of apoptotic cell [GO:0043652]; establishment or maintenance of cell polarity [GO:0007163]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular signal transduction [GO:0035556]; motor neuron axon guidance [GO:0008045]; neuromuscular process controlling balance [GO:0050885]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic actin cytoskeleton organization [GO:0098974]; Rac protein signal transduction [GO:0016601]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of neuron maturation [GO:0014041]; regulation of neutrophil migration [GO:1902622]; respiratory burst [GO:0045730]; synaptic transmission, GABAergic [GO:0051932]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Note=Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery.
P60842	reviewed	IF4A1_HUMAN	Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)	EIF4A1 DDX2A EIF4A	Homo sapiens (Human)	406	FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.		cytoplasmic translational initiation [GO:0002183]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; RNA helicase activity [GO:0003724]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; RNA helicase activity [GO:0003724]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; cytoplasmic translational initiation [GO:0002183]; translational initiation [GO:0006413]	
P60852	reviewed	ZP1_HUMAN	Zona pellucida sperm-binding protein 1 (Zona pellucida glycoprotein 1) (Zp-1) [Cleaved into: Processed zona pellucida sperm-binding protein 1]	ZP1	Homo sapiens (Human)	638	FUNCTION: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.		binding of sperm to zona pellucida [GO:0007339]; prevention of polyspermy [GO:0060468]	collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	acrosin binding [GO:0032190]; structural constituent of egg coat [GO:0035804]	collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; acrosin binding [GO:0032190]; structural constituent of egg coat [GO:0035804]; binding of sperm to zona pellucida [GO:0007339]; prevention of polyspermy [GO:0060468]	SUBCELLULAR LOCATION: [Processed zona pellucida sperm-binding protein 1]: Zona pellucida {ECO:0000269|PubMed:29895852}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48829}; Single-pass type I membrane protein {ECO:0000255}.
P60866	reviewed	RS20_HUMAN	Small ribosomal subunit protein uS10 (40S ribosomal protein S20)	RPS20	Homo sapiens (Human)	119	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). {ECO:0000269|PubMed:23636399}.		cytoplasmic translation [GO:0002181]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synapse [GO:0045202]	MDM2/MDM4 family protein binding [GO:0097371]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synapse [GO:0045202]; MDM2/MDM4 family protein binding [GO:0097371]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; cytoplasmic translation [GO:0002181]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P60880	reviewed	SNP25_HUMAN	Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein)	SNAP25 SNAP	Homo sapiens (Human)	206	FUNCTION: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. {ECO:0000250|UniProtKB:P60881}.	MISCELLANEOUS: When cloned and expressed in E.coli, where protein palmitoylation does not occur, Cys-85, Cys-88, Cys-90 and Cys-92 in the protein sequence readily form an iron-sulfur cluster. {ECO:0000269|PubMed:18375205}.	associative learning [GO:0008306]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; endosomal transport [GO:0016197]; exocytic insertion of neurotransmitter receptor to postsynaptic membrane [GO:0098967]; exocytosis [GO:0006887]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter uptake [GO:0001504]; positive regulation of insulin secretion [GO:0032024]; presynaptic dense core vesicle exocytosis [GO:0099525]; regulation of insulin secretion [GO:0050796]; regulation of neuron projection development [GO:0010975]; regulation of synapse assembly [GO:0051963]; SNARE complex assembly [GO:0035493]; synaptic vesicle docking [GO:0016081]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]	actin cytoskeleton [GO:0015629]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of presynaptic membrane [GO:0098888]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic active zone membrane [GO:0048787]; presynaptic membrane [GO:0042734]; ribbon synapse [GO:0097470]; SNARE complex [GO:0031201]; specific granule membrane [GO:0035579]; synaptic vesicle [GO:0008021]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [GO:0070032]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [GO:0070033]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802]; voltage-gated potassium channel complex [GO:0008076]	calcium-dependent protein binding [GO:0048306]; lipid binding [GO:0008289]; myosin binding [GO:0017022]; protein domain specific binding [GO:0019904]; SNAP receptor activity [GO:0005484]; syntaxin-1 binding [GO:0017075]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	actin cytoskeleton [GO:0015629]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of presynaptic membrane [GO:0098888]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic active zone membrane [GO:0048787]; presynaptic membrane [GO:0042734]; ribbon synapse [GO:0097470]; SNARE complex [GO:0031201]; specific granule membrane [GO:0035579]; synaptic vesicle [GO:0008021]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [GO:0070032]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [GO:0070033]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802]; voltage-gated potassium channel complex [GO:0008076]; calcium-dependent protein binding [GO:0048306]; lipid binding [GO:0008289]; myosin binding [GO:0017022]; protein domain specific binding [GO:0019904]; SNAP receptor activity [GO:0005484]; syntaxin-1 binding [GO:0017075]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; associative learning [GO:0008306]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; endosomal transport [GO:0016197]; exocytic insertion of neurotransmitter receptor to postsynaptic membrane [GO:0098967]; exocytosis [GO:0006887]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter uptake [GO:0001504]; positive regulation of insulin secretion [GO:0032024]; presynaptic dense core vesicle exocytosis [GO:0099525]; regulation of insulin secretion [GO:0050796]; regulation of neuron projection development [GO:0010975]; regulation of synapse assembly [GO:0051963]; SNARE complex assembly [GO:0035493]; synaptic vesicle docking [GO:0016081]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P60879}. Cell membrane {ECO:0000250|UniProtKB:P60881}; Lipid-anchor {ECO:0000250|UniProtKB:P60879}. Synapse, synaptosome {ECO:0000250|UniProtKB:P60879}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P60879}. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region. Colocalizes with KCNB1 at the cell membrane (By similarity). Colocalizes with PLCL1 at the cell membrane (By similarity). {ECO:0000250|UniProtKB:P60879, ECO:0000250|UniProtKB:P60881}.
P60891	reviewed	PRPS1_HUMAN	Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I)	PRPS1	Homo sapiens (Human)	318	FUNCTION: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. {ECO:0000269|PubMed:16939420, ECO:0000269|PubMed:17701900, ECO:0000269|PubMed:7593598}.		5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; hypoxanthine biosynthetic process [GO:0046101]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; ribonucleoside monophosphate biosynthetic process [GO:0009156]; urate biosynthetic process [GO:0034418]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribose phosphate diphosphokinase complex [GO:0002189]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribose phosphate diphosphokinase complex [GO:0002189]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; hypoxanthine biosynthetic process [GO:0046101]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; ribonucleoside monophosphate biosynthetic process [GO:0009156]; urate biosynthetic process [GO:0034418]	
P60896	reviewed	SEM1_HUMAN	26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein)	SEM1 C7orf76 DSS1 SHFDG1 SHFM1	Homo sapiens (Human)	70	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15117943, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:24896180}.		double-strand break repair via homologous recombination [GO:0000724]; mRNA export from nucleus [GO:0006406]; proteasome assembly [GO:0043248]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; protein-containing complex [GO:0032991]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; protein-containing complex [GO:0032991]; double-strand break repair via homologous recombination [GO:0000724]; mRNA export from nucleus [GO:0006406]; proteasome assembly [GO:0043248]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26833090}.
P60900	reviewed	PSA6_HUMAN	Proteasome subunit alpha type-6 (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain)	PSMA6 PROS27	Homo sapiens (Human)	246	FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of inflammatory response [GO:0050727]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myofibril [GO:0030016]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; polysome [GO:0005844]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; sarcomere [GO:0030017]	endopeptidase activity [GO:0004175]; NF-kappaB binding [GO:0051059]; purine ribonucleoside triphosphate binding [GO:0035639]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myofibril [GO:0030016]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; polysome [GO:0005844]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; sarcomere [GO:0030017]; endopeptidase activity [GO:0004175]; NF-kappaB binding [GO:0051059]; purine ribonucleoside triphosphate binding [GO:0035639]; RNA binding [GO:0003723]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QUM9, ECO:0000269|PubMed:12181345}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951). Colocalizes with TRIM5 in cytoplasmic bodies (By similarity). {ECO:0000250|UniProtKB:Q9QUM9, ECO:0000269|PubMed:34711951}.
P60903	reviewed	S10AA_HUMAN	Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11)	S100A10 ANX2LG CAL1L CLP11	Homo sapiens (Human)	97	FUNCTION: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.	MISCELLANEOUS: Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.	membrane raft assembly [GO:0001765]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of exocytosis [GO:0045921]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of plasma membrane repair [GO:1905686]; positive regulation of plasminogen activation [GO:0010756]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; regulation of neurogenesis [GO:0050767]; vesicle budding from membrane [GO:0006900]	AnxA2-p11 complex [GO:1990665]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nuclear matrix [GO:0016363]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; RNA polymerase II transcription regulator complex [GO:0090575]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; transmembrane transporter binding [GO:0044325]	AnxA2-p11 complex [GO:1990665]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nuclear matrix [GO:0016363]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; RNA polymerase II transcription regulator complex [GO:0090575]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; transmembrane transporter binding [GO:0044325]; membrane raft assembly [GO:0001765]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of exocytosis [GO:0045921]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of plasma membrane repair [GO:1905686]; positive regulation of plasminogen activation [GO:0010756]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; regulation of neurogenesis [GO:0050767]; vesicle budding from membrane [GO:0006900]	
P60953	reviewed	CDC42_HUMAN	Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)	CDC42	Homo sapiens (Human)	191	FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase (PubMed:15642749). Regulates cell migration (PubMed:17038317). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (PubMed:14978216). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation (PubMed:33523862). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (PubMed:26465210). {ECO:0000250|UniProtKB:P60766, ECO:0000250|UniProtKB:Q8CFN2, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:26465210, ECO:0000269|PubMed:33523862}.		actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; adherens junction organization [GO:0034332]; cardiac conduction system development [GO:0003161]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; Cdc42 protein signal transduction [GO:0032488]; cell junction assembly [GO:0034329]; cellular response to type II interferon [GO:0071346]; dendritic cell migration [GO:0036336]; dendritic spine morphogenesis [GO:0060997]; embryonic heart tube development [GO:0035050]; endocytosis [GO:0006897]; endothelin receptor signaling pathway involved in heart process [GO:0086101]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of Golgi localization [GO:0051683]; establishment or maintenance of cell polarity [GO:0007163]; filopodium assembly [GO:0046847]; Golgi organization [GO:0007030]; heart contraction [GO:0060047]; integrin-mediated signaling pathway [GO:0007229]; macrophage differentiation [GO:0030225]; modification of synaptic structure [GO:0099563]; modulation by host of viral process [GO:0044788]; negative regulation of protein-containing complex assembly [GO:0031333]; neuron fate determination [GO:0048664]; neuropilin signaling pathway [GO:0038189]; nuclear migration [GO:0007097]; organelle transport along microtubule [GO:0072384]; phagocytosis, engulfment [GO:0006911]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokinesis [GO:0032467]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of pinocytosis [GO:0048549]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization [GO:0008104]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of filopodium assembly [GO:0051489]; regulation of lamellipodium assembly [GO:0010591]; regulation of mitotic nuclear division [GO:0007088]; regulation of postsynapse organization [GO:0099175]; regulation of stress fiber assembly [GO:0051492]; substantia nigra development [GO:0021762]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	apical part of cell [GO:0045177]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle midzone [GO:0051233]; storage vacuole [GO:0000322]	apolipoprotein A-I receptor binding [GO:0034191]; G protein activity [GO:0003925]; GBD domain binding [GO:0032427]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996]; ubiquitin protein ligase activity [GO:0061630]	apical part of cell [GO:0045177]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle midzone [GO:0051233]; storage vacuole [GO:0000322]; apolipoprotein A-I receptor binding [GO:0034191]; G protein activity [GO:0003925]; GBD domain binding [GO:0032427]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996]; ubiquitin protein ligase activity [GO:0061630]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; adherens junction organization [GO:0034332]; cardiac conduction system development [GO:0003161]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; Cdc42 protein signal transduction [GO:0032488]; cell junction assembly [GO:0034329]; cellular response to type II interferon [GO:0071346]; dendritic cell migration [GO:0036336]; dendritic spine morphogenesis [GO:0060997]; embryonic heart tube development [GO:0035050]; endocytosis [GO:0006897]; endothelin receptor signaling pathway involved in heart process [GO:0086101]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of Golgi localization [GO:0051683]; establishment or maintenance of cell polarity [GO:0007163]; filopodium assembly [GO:0046847]; Golgi organization [GO:0007030]; heart contraction [GO:0060047]; integrin-mediated signaling pathway [GO:0007229]; macrophage differentiation [GO:0030225]; modification of synaptic structure [GO:0099563]; modulation by host of viral process [GO:0044788]; negative regulation of protein-containing complex assembly [GO:0031333]; neuron fate determination [GO:0048664]; neuropilin signaling pathway [GO:0038189]; nuclear migration [GO:0007097]; organelle transport along microtubule [GO:0072384]; phagocytosis, engulfment [GO:0006911]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokinesis [GO:0032467]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of pinocytosis [GO:0048549]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization [GO:0008104]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of filopodium assembly [GO:0051489]; regulation of lamellipodium assembly [GO:0010591]; regulation of mitotic nuclear division [GO:0007088]; regulation of postsynapse organization [GO:0099175]; regulation of stress fiber assembly [GO:0051492]; substantia nigra development [GO:0021762]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15642749}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15642749}. Midbody {ECO:0000269|PubMed:15642749}. Cell projection, dendrite {ECO:0000250|UniProtKB:P60766}. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase (PubMed:15642749). Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells (PubMed:15642749). Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1 (PubMed:15642749). Colocalizes with NEK6 in the centrosome (PubMed:20873783). In its active GTP-bound form localizes to the leading edge membrane of migrating dendritic cells (By similarity). {ECO:0000250|UniProtKB:P60766, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:20873783}.
P60981	reviewed	DEST_HUMAN	Destrin (Actin-depolymerizing factor) (ADF)	DSTN ACTDP DSN	Homo sapiens (Human)	165	FUNCTION: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. {ECO:0000269|PubMed:11812157}.		actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; positive regulation of actin filament depolymerization [GO:0030836]	actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; actin filament binding [GO:0051015]; actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; positive regulation of actin filament depolymerization [GO:0030836]	
P61006	reviewed	RAB8A_HUMAN	Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)	RAB8A MEL RAB8	Homo sapiens (Human)	207	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). Also involved in membrane trafficking to the cilium and ciliogenesis (PubMed:21844891, PubMed:30398148). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069). {ECO:0000250|UniProtKB:P35280, ECO:0000250|UniProtKB:P55258, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:30398148}.		autophagy [GO:0006914]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; Golgi organization [GO:0007030]; Golgi vesicle fusion to target membrane [GO:0048210]; neurotransmitter receptor transport to postsynaptic membrane [GO:0098969]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of autophagy [GO:0010506]; regulation of exocytosis [GO:0017157]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of protein transport [GO:0051223]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport in synapse [GO:0099003]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; non-motile cilium [GO:0097730]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein tyrosine kinase binding [GO:1990782]; small GTPase binding [GO:0031267]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; non-motile cilium [GO:0097730]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein tyrosine kinase binding [GO:1990782]; small GTPase binding [GO:0031267]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; Golgi organization [GO:0007030]; Golgi vesicle fusion to target membrane [GO:0048210]; neurotransmitter receptor transport to postsynaptic membrane [GO:0098969]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of autophagy [GO:0010506]; regulation of exocytosis [GO:0017157]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of protein transport [GO:0051223]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport in synapse [GO:0099003]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26824392, ECO:0000305|PubMed:12221131}; Lipid-anchor {ECO:0000305|PubMed:12221131}; Cytoplasmic side {ECO:0000305|PubMed:12221131}. Golgi apparatus {ECO:0000269|PubMed:15837803}. Recycling endosome membrane {ECO:0000269|PubMed:19864458}. Cell projection, cilium {ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:29125462}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q92930}; Lipid-anchor {ECO:0000250|UniProtKB:Q92930}; Cytoplasmic side {ECO:0000250|UniProtKB:Q92930}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:P55258}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:30398148}. Midbody {ECO:0000269|PubMed:22159412}. Cytoplasm {ECO:0000269|PubMed:26824392}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:30398148}. Note=Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane (PubMed:15837803). In the GDP-bound form, present in the perinuclear region (PubMed:12221131). Shows a polarized distribution to distal regions of cell protrusions in the GTP-bound form (PubMed:12221131). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Localizes to tubular recycling endosome (PubMed:19864458). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). Non-phosphorylated RAB8A predominantly localizes to the cytoplasm whereas phosphorylated RAB8A localizes to the membrane (PubMed:26824392, PubMed:29125462, PubMed:30398148). {ECO:0000269|PubMed:12221131, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:30398148}.
P61009	reviewed	SPCS3_HUMAN	Signal peptidase complex subunit 3 (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit)	SPCS3 SPC22 UNQ1841/PRO3567	Homo sapiens (Human)	180	FUNCTION: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:27499293, PubMed:34388369). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity). {ECO:0000250|UniProtKB:Q12133, ECO:0000269|PubMed:27499293, ECO:0000269|PubMed:34388369}.; FUNCTION: (Microbial infection) Plays an important role in virion production of flaviviruses such as West Nile virus, Japanese enchephalitis virus, Dengue virus type 2 and Yellow Fever virus. {ECO:0000269|PubMed:27383988}.		protein targeting to ER [GO:0045047]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465]; viral protein processing [GO:0019082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787]; protein targeting to ER [GO:0045047]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P61008}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P61008}.
P61011	reviewed	SRP54_HUMAN	Signal recognition particle subunit SRP54 (EC 3.6.5.4) (Signal recognition particle 54 kDa protein)	SRP54	Homo sapiens (Human)	504	FUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (PubMed:34020957). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (PubMed:34020957). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (PubMed:28972538, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (PubMed:34020957). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (PubMed:28972538, PubMed:29914977). {ECO:0000250|UniProtKB:P61010, ECO:0000269|PubMed:28972538, ECO:0000269|PubMed:29914977, ECO:0000269|PubMed:34020957}.		exocrine pancreas development [GO:0031017]; granulocyte differentiation [GO:0030851]; neutrophil chemotaxis [GO:0030593]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]	7S RNA binding [GO:0008312]; ATP hydrolysis activity [GO:0016887]; endoplasmic reticulum signal peptide binding [GO:0030942]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; ATP hydrolysis activity [GO:0016887]; endoplasmic reticulum signal peptide binding [GO:0030942]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; exocrine pancreas development [GO:0031017]; granulocyte differentiation [GO:0030851]; neutrophil chemotaxis [GO:0030593]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:14729963}. Cytoplasm {ECO:0000269|PubMed:14729963, ECO:0000269|PubMed:29914977}. Endoplasmic reticulum {ECO:0000269|PubMed:29914977}.
P61018	reviewed	RAB4B_HUMAN	Ras-related protein Rab-4B (EC 3.6.5.2)	RAB4B PP1596	Homo sapiens (Human)	213	FUNCTION: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Protein transport. Probably involved in vesicular traffic (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). {ECO:0000250|UniProtKB:P20338, ECO:0000250|UniProtKB:Q91ZR1}.		glucose import [GO:0046323]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192]	insulin-responsive compartment [GO:0032593]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; secretory granule membrane [GO:0030667]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	insulin-responsive compartment [GO:0032593]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; secretory granule membrane [GO:0030667]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; glucose import [GO:0046323]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P61019	reviewed	RAB2A_HUMAN	Ras-related protein Rab-2A (EC 3.6.5.2)	RAB2A RAB2	Homo sapiens (Human)	212	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi. {ECO:0000305|PubMed:26209634}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; nucleus [GO:0005634]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; nucleus [GO:0005634]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:17081065}; Lipid-anchor {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Endoplasmic reticulum membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Golgi apparatus membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P53994}. Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000250|UniProtKB:P53994, ECO:0000269|PubMed:17081065}.
P61020	reviewed	RAB5B_HUMAN	Ras-related protein Rab-5B (EC 3.6.5.2)	RAB5B	Homo sapiens (Human)	215	FUNCTION: Protein transport. Probably involved in vesicular traffic. {ECO:0000250|UniProtKB:P20339}.		antigen processing and presentation [GO:0019882]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; plasma membrane to endosome transport [GO:0048227]; regulation of endocytosis [GO:0030100]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; antigen processing and presentation [GO:0019882]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; plasma membrane to endosome transport [GO:0048227]; regulation of endocytosis [GO:0030100]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17081065}; Lipid-anchor {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Early endosome membrane {ECO:0000269|PubMed:17081065}; Lipid-anchor {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in stage I melanosomes. {ECO:0000269|PubMed:17081065}.
P61024	reviewed	CKS1_HUMAN	Cyclin-dependent kinases regulatory subunit 1 (CKS-1)	CKS1B CKS1 PNAS-143 PNAS-16	Homo sapiens (Human)	79	FUNCTION: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.		cell division [GO:0051301]; fibroblast proliferation [GO:0048144]; mitotic cell cycle phase transition [GO:0044772]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; histone binding [GO:0042393]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; histone binding [GO:0042393]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; cell division [GO:0051301]; fibroblast proliferation [GO:0048144]; mitotic cell cycle phase transition [GO:0044772]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]	
P61026	reviewed	RAB10_HUMAN	Ras-related protein Rab-10 (EC 3.6.5.2)	RAB10	Homo sapiens (Human)	200	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Also plays a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148). {ECO:0000250|UniProtKB:P24409, ECO:0000250|UniProtKB:P61027, ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164, ECO:0000269|PubMed:23263280, ECO:0000269|PubMed:30398148}.; FUNCTION: (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole. {ECO:0000269|PubMed:31540829}.		antigen processing and presentation [GO:0019882]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; endoplasmic reticulum tubular network organization [GO:0071786]; endosomal transport [GO:0016197]; establishment of neuroblast polarity [GO:0045200]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; establishment of protein localization to membrane [GO:0090150]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; polarized epithelial cell differentiation [GO:0030859]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to plasma membrane [GO:0072659]; regulated exocytosis [GO:0045055]; vesicle-mediated transport [GO:0016192]	adherens junction [GO:0005912]; cilium [GO:0005929]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endosome [GO:0005768]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; insulin-responsive compartment [GO:0032593]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]	cadherin binding involved in cell-cell adhesion [GO:0098641]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; myosin V binding [GO:0031489]	adherens junction [GO:0005912]; cilium [GO:0005929]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endosome [GO:0005768]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; insulin-responsive compartment [GO:0032593]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; cadherin binding involved in cell-cell adhesion [GO:0098641]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; myosin V binding [GO:0031489]; antigen processing and presentation [GO:0019882]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; endoplasmic reticulum tubular network organization [GO:0071786]; endosomal transport [GO:0016197]; establishment of neuroblast polarity [GO:0045200]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; establishment of protein localization to membrane [GO:0090150]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; polarized epithelial cell differentiation [GO:0030859]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to plasma membrane [GO:0072659]; regulated exocytosis [GO:0045055]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:23263280}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P24409}. Endosome membrane {ECO:0000269|PubMed:16641372}. Recycling endosome membrane {ECO:0000250|UniProtKB:P24409}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:P24409}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:20576682, ECO:0000269|PubMed:30398148}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23263280, ECO:0000269|PubMed:24891604}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:29212815}. Note=Associates with SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Localizes to the base of the cilium when phosphorylated by LRRK2 on Thr-73 (PubMed:20576682, PubMed:30398148). Transiently associates with phagosomes (By similarity). Localizes to the endoplasmic reticulum at domains of new tubule growth (PubMed:23263280). {ECO:0000250|UniProtKB:P24409, ECO:0000269|PubMed:20576682, ECO:0000269|PubMed:22908308, ECO:0000269|PubMed:23263280, ECO:0000269|PubMed:30398148}.
P61073	reviewed	CXCR4_HUMAN	C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)	CXCR4	Homo sapiens (Human)	352	FUNCTION: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). {ECO:0000250|UniProtKB:P70658, ECO:0000269|PubMed:10074102, ECO:0000269|PubMed:10452968, ECO:0000269|PubMed:10644702, ECO:0000269|PubMed:10825158, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:17197449, ECO:0000269|PubMed:18799424, ECO:0000269|PubMed:20048153, ECO:0000269|PubMed:20228059, ECO:0000269|PubMed:20505072, ECO:0000269|PubMed:24912431, ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:8752280, ECO:0000269|PubMed:8752281}.; FUNCTION: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:8849450, PubMed:8929542, PubMed:9427609, PubMed:10074122, PubMed:10756055). {ECO:0000269|PubMed:10074122, ECO:0000269|PubMed:10756055, ECO:0000269|PubMed:8849450, ECO:0000269|PubMed:8929542, ECO:0000269|PubMed:9427609}.	MISCELLANEOUS: Plerixafor (AMD3100), an antagonist of CXCR4 activity, blocks HIV-1 entry, interaction with CXCL12 and subsequent CXCR4 signaling.	apoptotic process [GO:0006915]; brain development [GO:0007420]; calcium-mediated signaling [GO:0019722]; cardiac muscle contraction [GO:0060048]; cell chemotaxis [GO:0060326]; cellular response to cytokine stimulus [GO:0071345]; cellular response to organonitrogen compound [GO:0071417]; cellular response to xenobiotic stimulus [GO:0071466]; CXCL12-activated CXCR4 signaling pathway [GO:0038160]; dendritic cell chemotaxis [GO:0002407]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; endothelial cell differentiation [GO:0045446]; endothelial tube morphogenesis [GO:0061154]; epithelial cell development [GO:0002064]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; myelin maintenance [GO:0043217]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; neuron recognition [GO:0008038]; positive regulation of cell migration [GO:0030335]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendrite extension [GO:1903861]; positive regulation of macrophage migration inhibitory factor signaling pathway [GO:2000448]; positive regulation of mesenchymal stem cell migration [GO:1905322]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of vascular wound healing [GO:0035470]; regulation of calcium ion transport [GO:0051924]; regulation of cell adhesion [GO:0030155]; regulation of chemotaxis [GO:0050920]; regulation of programmed cell death [GO:0043067]; regulation of viral process [GO:0050792]; response to activity [GO:0014823]; response to hypoxia [GO:0001666]; response to tacrolimus [GO:1901327]; response to ultrasound [GO:1990478]; response to virus [GO:0009615]; telencephalon cell migration [GO:0022029]	anchoring junction [GO:0070161]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	actin binding [GO:0003779]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine receptor activity [GO:0016494]; C-X-C motif chemokine 12 receptor activity [GO:0038147]; coreceptor activity [GO:0015026]; G protein-coupled receptor activity [GO:0004930]; myosin light chain binding [GO:0032027]; small molecule binding [GO:0036094]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; virus receptor activity [GO:0001618]	anchoring junction [GO:0070161]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; actin binding [GO:0003779]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine receptor activity [GO:0016494]; C-X-C motif chemokine 12 receptor activity [GO:0038147]; coreceptor activity [GO:0015026]; G protein-coupled receptor activity [GO:0004930]; myosin light chain binding [GO:0032027]; small molecule binding [GO:0036094]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; virus receptor activity [GO:0001618]; apoptotic process [GO:0006915]; brain development [GO:0007420]; calcium-mediated signaling [GO:0019722]; cardiac muscle contraction [GO:0060048]; cell chemotaxis [GO:0060326]; cellular response to cytokine stimulus [GO:0071345]; cellular response to organonitrogen compound [GO:0071417]; cellular response to xenobiotic stimulus [GO:0071466]; CXCL12-activated CXCR4 signaling pathway [GO:0038160]; dendritic cell chemotaxis [GO:0002407]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; endothelial cell differentiation [GO:0045446]; endothelial tube morphogenesis [GO:0061154]; epithelial cell development [GO:0002064]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; myelin maintenance [GO:0043217]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; neuron recognition [GO:0008038]; positive regulation of cell migration [GO:0030335]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendrite extension [GO:1903861]; positive regulation of macrophage migration inhibitory factor signaling pathway [GO:2000448]; positive regulation of mesenchymal stem cell migration [GO:1905322]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of vascular wound healing [GO:0035470]; regulation of calcium ion transport [GO:0051924]; regulation of cell adhesion [GO:0030155]; regulation of chemotaxis [GO:0050920]; regulation of programmed cell death [GO:0043067]; regulation of viral process [GO:0050792]; response to activity [GO:0014823]; response to hypoxia [GO:0001666]; response to tacrolimus [GO:1901327]; response to ultrasound [GO:1990478]; response to virus [GO:0009615]; telencephalon cell migration [GO:0022029]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10452968, ECO:0000305|PubMed:20929726}; Multi-pass membrane protein {ECO:0000269|PubMed:20929726}. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC).
P61077	reviewed	UB2D3_HUMAN	Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)	UBE2D3 UBC5C UBCH5C	Homo sapiens (Human)	147	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:15247280, PubMed:15496420, PubMed:18284575, PubMed:20061386, PubMed:21532592). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination (PubMed:15247280, PubMed:15496420, PubMed:18284575, PubMed:20061386, PubMed:21532592). Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation (PubMed:20347421). Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin (PubMed:10329681). Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin (PubMed:10329681). Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA (PubMed:18948756). Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase (PubMed:18948756). Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair (PubMed:16628214). Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus (PubMed:18515077). In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53 (PubMed:12646252, PubMed:15280377). In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes (PubMed:18508924). In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction (PubMed:11743028). Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175). Together with ZNF598, catalyzes ubiquitination of 40S ribosomal proteins in response to ribosome collisions (PubMed:28685749). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2 (PubMed:36528027). {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:11743028, ECO:0000269|PubMed:12646252, ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15280377, ECO:0000269|PubMed:15496420, ECO:0000269|PubMed:16628214, ECO:0000269|PubMed:18284575, ECO:0000269|PubMed:18508924, ECO:0000269|PubMed:18515077, ECO:0000269|PubMed:18948756, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20347421, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:28685749, ECO:0000269|PubMed:36528027}.		apoptotic process [GO:0006915]; DNA repair [GO:0006281]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein modification process [GO:0036211]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; DNA repair [GO:0006281]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein modification process [GO:0036211]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18508924}; Peripheral membrane protein {ECO:0000269|PubMed:18508924}. Endosome membrane {ECO:0000269|PubMed:18508924}; Peripheral membrane protein {ECO:0000269|PubMed:18508924}.
P61081	reviewed	UBC12_HUMAN	NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)	UBE2M UBC12	Homo sapiens (Human)	183	FUNCTION: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:15361859}.		positive regulation of neuron apoptotic process [GO:0043525]; post-translational protein modification [GO:0043687]; protein modification process [GO:0036211]; protein neddylation [GO:0045116]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; NEDD8 conjugating enzyme activity [GO:0061654]; NEDD8 transferase activity [GO:0019788]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; NEDD8 conjugating enzyme activity [GO:0061654]; NEDD8 transferase activity [GO:0019788]; ubiquitin-protein transferase activity [GO:0004842]; positive regulation of neuron apoptotic process [GO:0043525]; post-translational protein modification [GO:0043687]; protein modification process [GO:0036211]; protein neddylation [GO:0045116]	
P61086	reviewed	UBE2K_HUMAN	Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)	UBE2K HIP2 LIG	Homo sapiens (Human)	200	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1. {ECO:0000269|PubMed:10634809, ECO:0000269|PubMed:10675012, ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:17873885, ECO:0000269|PubMed:19906396, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:8702625}.	MISCELLANEOUS: [Isoform 2]: May be inactive. {ECO:0000305}.	cellular response to interferon-beta [GO:0035458]; free ubiquitin chain polymerization [GO:0010994]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium tip [GO:0032433]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium tip [GO:0032433]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]; cellular response to interferon-beta [GO:0035458]; free ubiquitin chain polymerization [GO:0010994]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P61085}.
P61088	reviewed	UBE2N_HUMAN	Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)	UBE2N BLU	Homo sapiens (Human)	152	FUNCTION: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175, PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. {ECO:0000269|PubMed:10089880, ECO:0000269|PubMed:14562038, ECO:0000269|PubMed:19269966, ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:31006531}.		antiviral innate immune response [GO:0140374]; DNA double-strand break processing [GO:0000729]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; postreplication repair [GO:0006301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of DNA repair [GO:0006282]; regulation of histone ubiquitination [GO:0033182]; T cell receptor signaling pathway [GO:0050852]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; UBC13-MMS2 complex [GO:0031372]; UBC13-UEV1A complex [GO:0035370]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151]	ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activator activity [GO:0097027]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; UBC13-MMS2 complex [GO:0031372]; UBC13-UEV1A complex [GO:0035370]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activator activity [GO:0097027]; ubiquitin-protein transferase activity [GO:0004842]; antiviral innate immune response [GO:0140374]; DNA double-strand break processing [GO:0000729]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; postreplication repair [GO:0006301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of DNA repair [GO:0006282]; regulation of histone ubiquitination [GO:0033182]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19340006}. Cytoplasm {ECO:0000269|PubMed:19340006}.
P61106	reviewed	RAB14_HUMAN	Ras-related protein Rab-14	RAB14	Homo sapiens (Human)	215	FUNCTION: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. {ECO:0000250, ECO:0000269|PubMed:22595670}.		defense response to bacterium [GO:0042742]; endocytic recycling [GO:0032456]; fibroblast growth factor receptor signaling pathway [GO:0008543]; Golgi to endosome transport [GO:0006895]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; phagolysosome assembly involved in apoptotic cell clearance [GO:0090387]; phagosome maturation [GO:0090382]; regulation of embryonic development [GO:0045995]; regulation of protein localization [GO:0032880]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nuclear outer membrane-endoplasmic reticulum membrane network [GO:0042175]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; rough endoplasmic reticulum [GO:0005791]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nuclear outer membrane-endoplasmic reticulum membrane network [GO:0042175]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; rough endoplasmic reticulum [GO:0005791]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; defense response to bacterium [GO:0042742]; endocytic recycling [GO:0032456]; fibroblast growth factor receptor signaling pathway [GO:0008543]; Golgi to endosome transport [GO:0006895]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; phagolysosome assembly involved in apoptotic cell clearance [GO:0090387]; phagosome maturation [GO:0090382]; regulation of embryonic development [GO:0045995]; regulation of protein localization [GO:0032880]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Recycling endosome {ECO:0000269|PubMed:22595670}. Early endosome membrane {ECO:0000269|PubMed:16962593}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:16962593}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16962593}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Note=Recruited to recycling endosomes by DENND6A (PubMed:22595670). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:22595670}.
P61158	reviewed	ARP3_HUMAN	Actin-related protein 3 (Actin-like protein 3)	ACTR3 ARP3	Homo sapiens (Human)	418	FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}.		actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; asymmetric cell division [GO:0008356]; cellular response to type II interferon [GO:0071346]; cilium assembly [GO:0060271]; establishment or maintenance of cell polarity [GO:0007163]; meiotic chromosome movement towards spindle pole [GO:0016344]; meiotic cytokinesis [GO:0033206]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spindle localization [GO:0051653]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; brush border [GO:0005903]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	actin binding [GO:0003779]; ATP binding [GO:0005524]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; brush border [GO:0005903]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; actin binding [GO:0003779]; ATP binding [GO:0005524]; structural constituent of cytoskeleton [GO:0005200]; actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; asymmetric cell division [GO:0008356]; cellular response to type II interferon [GO:0071346]; cilium assembly [GO:0060271]; establishment or maintenance of cell polarity [GO:0007163]; meiotic chromosome movement towards spindle pole [GO:0016344]; meiotic cytokinesis [GO:0033206]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spindle localization [GO:0051653]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19109554}. Cell projection {ECO:0000269|PubMed:9230079}. Nucleus {ECO:0000269|PubMed:16767080, ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:29925947}. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554).
P61160	reviewed	ARP2_HUMAN	Actin-related protein 2 (Actin-like protein 2)	ACTR2 ARP2	Homo sapiens (Human)	394	FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}.		Arp2/3 complex-mediated actin nucleation [GO:0034314]; asymmetric cell division [GO:0008356]; cellular response to type II interferon [GO:0071346]; cilium assembly [GO:0060271]; cytosolic transport [GO:0016482]; establishment or maintenance of cell polarity [GO:0007163]; meiotic chromosome movement towards spindle pole [GO:0016344]; meiotic cytokinesis [GO:0033206]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spindle localization [GO:0051653]	actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; azurophil granule lumen [GO:0035578]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	actin binding [GO:0003779]; ATP binding [GO:0005524]; structural constituent of cytoskeleton [GO:0005200]	actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; azurophil granule lumen [GO:0035578]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; actin binding [GO:0003779]; ATP binding [GO:0005524]; structural constituent of cytoskeleton [GO:0005200]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; asymmetric cell division [GO:0008356]; cellular response to type II interferon [GO:0071346]; cilium assembly [GO:0060271]; cytosolic transport [GO:0016482]; establishment or maintenance of cell polarity [GO:0007163]; meiotic chromosome movement towards spindle pole [GO:0016344]; meiotic cytokinesis [GO:0033206]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spindle localization [GO:0051653]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9000076}. Cell projection {ECO:0000269|PubMed:9000076}. Nucleus {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:29925947}.
P61163	reviewed	ACTZ_HUMAN	Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)	ACTR1A CTRN1	Homo sapiens (Human)	376	FUNCTION: Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:F2Z5G5}.		vesicle-mediated transport [GO:0016192]	cell cortex region [GO:0099738]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; extracellular exosome [GO:0070062]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]	ATP binding [GO:0005524]	cell cortex region [GO:0099738]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; extracellular exosome [GO:0070062]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; ATP binding [GO:0005524]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P85515}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cell cortex {ECO:0000269|PubMed:22327364}.
P61165	reviewed	TM258_HUMAN	Transmembrane protein 258 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258) (Oligosaccharyl transferase subunit TMEM258)	TMEM258 C11orf10 HSPC005	Homo sapiens (Human)	79	FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:26472760, PubMed:27974209). Involved in ER homeostasis in the colonic epithelium (By similarity). {ECO:0000250|UniProtKB:P61166, ECO:0000269|PubMed:26472760, ECO:0000269|PubMed:27974209, ECO:0000269|PubMed:31831667}.		epithelial cell apoptotic process [GO:1904019]; inflammatory response [GO:0006954]; protein N-linked glycosylation [GO:0006487]; response to endoplasmic reticulum stress [GO:0034976]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; membrane-bounded organelle [GO:0043227]; oligosaccharyltransferase complex [GO:0008250]; oligosaccharyltransferase I complex [GO:0034998]; protein-containing complex [GO:0032991]	oligosaccharyltransferase complex binding [GO:0062062]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; membrane-bounded organelle [GO:0043227]; oligosaccharyltransferase complex [GO:0008250]; oligosaccharyltransferase I complex [GO:0034998]; protein-containing complex [GO:0032991]; oligosaccharyltransferase complex binding [GO:0062062]; epithelial cell apoptotic process [GO:1904019]; inflammatory response [GO:0006954]; protein N-linked glycosylation [GO:0006487]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:28716842}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:26472760, ECO:0000269|PubMed:27974209}. Cytoplasm {ECO:0000269|PubMed:12427278, ECO:0000269|PubMed:28716842}.
P61201	reviewed	CSN2_HUMAN	COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)	COPS2 CSN2 TRIP15	Homo sapiens (Human)	443	FUNCTION: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.		inner cell mass cell proliferation [GO:0001833]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; protein phosphorylation [GO:0006468]; regulation of protein neddylation [GO:2000434]; signal transduction [GO:0007165]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase II [GO:0006366]; trophectodermal cell proliferation [GO:0001834]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription corepressor activity [GO:0003714]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription corepressor activity [GO:0003714]; inner cell mass cell proliferation [GO:0001833]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; protein phosphorylation [GO:0006468]; regulation of protein neddylation [GO:2000434]; signal transduction [GO:0007165]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase II [GO:0006366]; trophectodermal cell proliferation [GO:0001834]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:10207062}.
P61204	reviewed	ARF3_HUMAN	ADP-ribosylation factor 3	ARF3	Homo sapiens (Human)	181	FUNCTION: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.		intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:17555535}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17555535}.
P61218	reviewed	RPAB2_HUMAN	DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (DNA-directed RNA polymerase II subunit F) (DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide) (RPABC14.4) (RPB14.4) (RPB6 homolog) (RPC15)	POLR2F POLRF	Homo sapiens (Human)	127	FUNCTION: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.		transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; tRNA transcription by RNA polymerase III [GO:0042797]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; tRNA transcription by RNA polymerase III [GO:0042797]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
P61221	reviewed	ABCE1_HUMAN	ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I)	ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40	Homo sapiens (Human)	599	FUNCTION: Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:9660177, PubMed:9847332, PubMed:11585831). {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:20122402, ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. {ECO:0000269|PubMed:9660177}.	MISCELLANEOUS: The ABC transporter domains seem not to be functional.	negative regulation of endoribonuclease activity [GO:0060702]; regulation of translation [GO:0006417]; rescue of stalled ribosome [GO:0072344]; ribosomal subunit export from nucleus [GO:0000054]; ribosome disassembly [GO:0032790]; translational initiation [GO:0006413]; translational termination [GO:0006415]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; CTPase activity [GO:0043273]; endoribonuclease inhibitor activity [GO:0060698]; GTPase activity [GO:0003924]; iron ion binding [GO:0005506]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosomal small subunit binding [GO:0043024]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; CTPase activity [GO:0043273]; endoribonuclease inhibitor activity [GO:0060698]; GTPase activity [GO:0003924]; iron ion binding [GO:0005506]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosomal small subunit binding [GO:0043024]; negative regulation of endoribonuclease activity [GO:0060702]; regulation of translation [GO:0006417]; rescue of stalled ribosome [GO:0072344]; ribosomal subunit export from nucleus [GO:0000054]; ribosome disassembly [GO:0032790]; translational initiation [GO:0006413]; translational termination [GO:0006415]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}.
P61224	reviewed	RAP1B_HUMAN	Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)	RAP1B OK/SW-cl.11	Homo sapiens (Human)	184	FUNCTION: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. {ECO:0000269|PubMed:18660803, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21840392}.		calcium-ion regulated exocytosis [GO:0017156]; cell population proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; establishment of endothelial barrier [GO:0061028]; establishment of localization in cell [GO:0051649]; modification of postsynaptic structure [GO:0099010]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of integrin activation [GO:0033625]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of establishment of cell polarity [GO:2000114]	azurophil granule membrane [GO:0035577]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-containing complex binding [GO:0044877]	azurophil granule membrane [GO:0035577]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-containing complex binding [GO:0044877]; calcium-ion regulated exocytosis [GO:0017156]; cell population proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; establishment of endothelial barrier [GO:0061028]; establishment of localization in cell [GO:0051649]; modification of postsynaptic structure [GO:0099010]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of integrin activation [GO:0033625]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of establishment of cell polarity [GO:2000114]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:3141412}. Cytoplasm, cytosol {ECO:0000269|PubMed:3141412}. Cell junction {ECO:0000269|PubMed:20332120}. Note=May shuttle between plasma membrane and cytosol (PubMed:3141412). Presence of KRIT1 and CDH5 is required for its localization to the cell junction (PubMed:20332120). {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:3141412}.
P61225	reviewed	RAP2B_HUMAN	Ras-related protein Rap-2b (EC 3.6.5.2)	RAP2B	Homo sapiens (Human)	183	FUNCTION: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. {ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:15143162, ECO:0000269|PubMed:16540189}.		negative regulation of cell migration [GO:0030336]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of protein autophosphorylation [GO:0031954]; Rap protein signal transduction [GO:0032486]; regulation of protein tyrosine kinase activity [GO:0061097]; signal transduction [GO:0007165]	bicellular tight junction [GO:0005923]; cell-cell contact zone [GO:0044291]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein domain specific binding [GO:0019904]	bicellular tight junction [GO:0005923]; cell-cell contact zone [GO:0044291]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein domain specific binding [GO:0019904]; negative regulation of cell migration [GO:0030336]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of protein autophosphorylation [GO:0031954]; Rap protein signal transduction [GO:0032486]; regulation of protein tyrosine kinase activity [GO:0061097]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:16540189}; Lipid-anchor {ECO:0000269|PubMed:16540189}; Cytoplasmic side {ECO:0000269|PubMed:16540189}. Note=Associated with red blood cells-released vesicles.
P61244	reviewed	MAX_HUMAN	Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)	MAX BHLHD4	Homo sapiens (Human)	160	FUNCTION: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to peptide hormone stimulus [GO:0071375]; cellular response to starvation [GO:0009267]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of transcription by RNA polymerase II [GO:0006357]; response to axon injury [GO:0048678]; response to insulin [GO:0032868]; retina development in camera-type eye [GO:0060041]	chromatin [GO:0000785]; dendrite [GO:0030425]; Mad-Max complex [GO:0070443]; MLL1 complex [GO:0071339]; Myc-Max complex [GO:0071943]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein-containing complex binding [GO:0044877]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; dendrite [GO:0030425]; Mad-Max complex [GO:0070443]; MLL1 complex [GO:0071339]; Myc-Max complex [GO:0071943]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein-containing complex binding [GO:0044877]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to starvation [GO:0009267]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of transcription by RNA polymerase II [GO:0006357]; response to axon injury [GO:0048678]; response to insulin [GO:0032868]; retina development in camera-type eye [GO:0060041]	SUBCELLULAR LOCATION: Nucleus. Cell projection, dendrite {ECO:0000250}.
P61247	reviewed	RS3A_HUMAN	Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1)	RPS3A FTE1 MFTL	Homo sapiens (Human)	264	FUNCTION: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		cell differentiation [GO:0030154]; cytoplasmic translation [GO:0002181]; negative regulation of apoptotic process [GO:0043066]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; small-subunit processome [GO:0032040]; synapse [GO:0045202]	mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cell differentiation [GO:0030154]; cytoplasmic translation [GO:0002181]; negative regulation of apoptotic process [GO:0043066]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:23636399}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03122}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
P61254	reviewed	RL26_HUMAN	Large ribosomal subunit protein uL24 (60S ribosomal protein L26)	RPL26	Homo sapiens (Human)	145	FUNCTION: Component of the large ribosomal subunit (PubMed:26100019, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:26100019, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:26100019}.		cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; cytoplasmic translation [GO:0002181]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902167]; positive regulation of translation [GO:0045727]; regulation of translation involved in cellular response to UV [GO:1904803]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]	mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; cytoplasmic translation [GO:0002181]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902167]; positive regulation of translation [GO:0045727]; regulation of translation involved in cellular response to UV [GO:1904803]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P61266	reviewed	STX1B_HUMAN	Syntaxin-1B (Syntaxin-1B1) (Syntaxin-1B2)	STX1B STX1B1 STX1B2	Homo sapiens (Human)	288	FUNCTION: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: The glycine-rich C-terminus serves as an unconventional nuclear localization signal. {ECO:0000305}.	calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; exocytic insertion of neurotransmitter receptor to postsynaptic membrane [GO:0098967]; intracellular protein transport [GO:0006886]; negative regulation of macropinocytosis [GO:1905302]; negative regulation of neuron projection development [GO:0010977]; negative regulation of synaptic vesicle recycling [GO:1903422]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of spontaneous neurotransmitter secretion [GO:1904050]; regulation of gene expression [GO:0010468]; regulation of synaptic activity [GO:0060025]; regulation of synaptic vesicle priming [GO:0010807]; spontaneous neurotransmitter secretion [GO:0061669]; synaptic vesicle docking [GO:0016081]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion [GO:0006906]	axon [GO:0030424]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; neuromuscular junction [GO:0031594]; nuclear lamina [GO:0005652]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201]; spindle [GO:0005819]	protein kinase binding [GO:0019901]; signaling receptor binding [GO:0005102]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	axon [GO:0030424]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; neuromuscular junction [GO:0031594]; nuclear lamina [GO:0005652]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201]; spindle [GO:0005819]; protein kinase binding [GO:0019901]; signaling receptor binding [GO:0005102]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; exocytic insertion of neurotransmitter receptor to postsynaptic membrane [GO:0098967]; intracellular protein transport [GO:0006886]; negative regulation of macropinocytosis [GO:1905302]; negative regulation of neuron projection development [GO:0010977]; negative regulation of synaptic vesicle recycling [GO:1903422]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of spontaneous neurotransmitter secretion [GO:1904050]; regulation of gene expression [GO:0010468]; regulation of synaptic activity [GO:0060025]; regulation of synaptic vesicle priming [GO:0010807]; spontaneous neurotransmitter secretion [GO:0061669]; synaptic vesicle docking [GO:0016081]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:18691641}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18691641}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18691641}. Note=Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and with NuMA and gamma-tubulin in the pericentrosomal region of the mitotic spindle in dividing cells.
P61278	reviewed	SMS_HUMAN	Somatostatin (Growth hormone release-inhibiting factor) [Cleaved into: Somatostatin-28; Somatostatin-14 (SST-14); Neuronostatin (NST)]	SST	Homo sapiens (Human)	116	FUNCTION: [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. {ECO:0000269|PubMed:29615476}.; FUNCTION: [Neuronostatin]: May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity). This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed:29615476). {ECO:0000250|UniProtKB:P60041, ECO:0000250|UniProtKB:P60042, ECO:0000269|PubMed:29615476}.		cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; digestion [GO:0007586]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated apoptotic signaling pathway [GO:0008628]; hyperosmotic response [GO:0006972]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell migration [GO:0030334]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to acidic pH [GO:0010447]; response to amino acid [GO:0043200]; response to nutrient [GO:0007584]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]	hormone activity [GO:0005179]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; hormone activity [GO:0005179]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; digestion [GO:0007586]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated apoptotic signaling pathway [GO:0008628]; hyperosmotic response [GO:0006972]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell migration [GO:0030334]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to acidic pH [GO:0010447]; response to amino acid [GO:0043200]; response to nutrient [GO:0007584]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60042}.
P61289	reviewed	PSME3_HUMAN	Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma)	PSME3	Homo sapiens (Human)	254	FUNCTION: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). {ECO:0000269|PubMed:10835274, ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824, ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]	endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]; endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10657252, ECO:0000269|PubMed:12629132}. Cytoplasm {ECO:0000250}. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.
P61296	reviewed	HAND2_HUMAN	Heart- and neural crest derivatives-expressed protein 2 (Class A basic helix-loop-helix protein 26) (bHLHa26) (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND)	HAND2 BHLHA26 DHAND	Homo sapiens (Human)	217	FUNCTION: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). {ECO:0000250}.		adult heart development [GO:0007512]; angiogenesis [GO:0001525]; apoptotic process involved in heart morphogenesis [GO:0003278]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cardiac right ventricle formation [GO:0003219]; cartilage morphogenesis [GO:0060536]; cell proliferation involved in outflow tract morphogenesis [GO:0061325]; cellular response to organic cyclic compound [GO:0071407]; cellular response to retinoic acid [GO:0071300]; coronary artery morphogenesis [GO:0060982]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; epithelial cell apoptotic process [GO:1904019]; heart development [GO:0007507]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; mesenchymal cell proliferation [GO:0010463]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoblast differentiation [GO:0045668]; noradrenergic neuron differentiation [GO:0003357]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system neuron development [GO:0048935]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis [GO:2000764]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process [GO:2000763]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; primary palate development [GO:1903929]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; regulation of tissue remodeling [GO:0034103]; regulation of transcription by RNA polymerase II [GO:0006357]; suckling behavior [GO:0001967]; sympathetic nervous system development [GO:0048485]; thymus development [GO:0048538]; tongue development [GO:0043586]; visceral serous pericardium development [GO:0061032]	chromatin [GO:0000785]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein homodimerization activity [GO:0042803]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]	chromatin [GO:0000785]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein homodimerization activity [GO:0042803]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]; adult heart development [GO:0007512]; angiogenesis [GO:0001525]; apoptotic process involved in heart morphogenesis [GO:0003278]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cardiac right ventricle formation [GO:0003219]; cartilage morphogenesis [GO:0060536]; cell proliferation involved in outflow tract morphogenesis [GO:0061325]; cellular response to organic cyclic compound [GO:0071407]; cellular response to retinoic acid [GO:0071300]; coronary artery morphogenesis [GO:0060982]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; epithelial cell apoptotic process [GO:1904019]; heart development [GO:0007507]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; mesenchymal cell proliferation [GO:0010463]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoblast differentiation [GO:0045668]; noradrenergic neuron differentiation [GO:0003357]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system neuron development [GO:0048935]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis [GO:2000764]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process [GO:2000763]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; primary palate development [GO:1903929]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; regulation of tissue remodeling [GO:0034103]; regulation of transcription by RNA polymerase II [GO:0006357]; suckling behavior [GO:0001967]; sympathetic nervous system development [GO:0048485]; thymus development [GO:0048538]; tongue development [GO:0043586]; visceral serous pericardium development [GO:0061032]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
P61313	reviewed	RL15_HUMAN	Large ribosomal subunit protein eL15 (60S ribosomal protein L15)	RPL15 EC45 TCBAP0781	Homo sapiens (Human)	204	FUNCTION: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]; ribosome [GO:0005840]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]; ribosome [GO:0005840]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P61326	reviewed	MGN_HUMAN	Protein mago nashi homolog	MAGOH MAGOHA	Homo sapiens (Human)	146	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638). Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12730685, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:23917022}.		mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA processing [GO:0050684]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; exon-exon junction subcomplex mago-y14 [GO:1990501]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; exon-exon junction subcomplex mago-y14 [GO:1990501]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA processing [GO:0050684]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19324961}. Nucleus speckle {ECO:0000269|PubMed:19324961}. Cytoplasm {ECO:0000269|PubMed:19324961}. Note=Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles (PubMed:19324961). {ECO:0000250, ECO:0000250|UniProtKB:Q27W02, ECO:0000269|PubMed:19324961}.
P61328	reviewed	FGF12_HUMAN	Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) (Myocyte-activating factor)	FGF12 FGF12B FHF1	Homo sapiens (Human)	243	FUNCTION: Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. {ECO:0000269|PubMed:27164707}.		adult locomotory behavior [GO:0008344]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; heart development [GO:0007507]; JNK cascade [GO:0007254]; nervous system development [GO:0007399]; neuromuscular process [GO:0050905]; positive regulation of sodium ion transport [GO:0010765]; regulation of neuronal action potential [GO:0098908]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of voltage-gated sodium channel activity [GO:1905150]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; synapse [GO:0045202]	growth factor activity [GO:0008083]; heparin binding [GO:0008201]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; synapse [GO:0045202]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; adult locomotory behavior [GO:0008344]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; heart development [GO:0007507]; JNK cascade [GO:0007254]; nervous system development [GO:0007399]; neuromuscular process [GO:0050905]; positive regulation of sodium ion transport [GO:0010765]; regulation of neuronal action potential [GO:0098908]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of voltage-gated sodium channel activity [GO:1905150]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P61353	reviewed	RL27_HUMAN	Large ribosomal subunit protein eL27 (60S ribosomal protein L27)	RPL27	Homo sapiens (Human)	136	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680, PubMed:32669547). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; response to aldosterone [GO:1904044]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; synapse [GO:0045202]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; response to aldosterone [GO:1904044]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:A1XQU5}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:A1XQU5, ECO:0000269|PubMed:25957688}.
P61371	reviewed	ISL1_HUMAN	Insulin gene enhancer protein ISL-1 (Islet-1)	ISL1	Homo sapiens (Human)	349	FUNCTION: DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). Binds to insulin gene enhancer sequences (By similarity). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity). {ECO:0000250|UniProtKB:P61372, ECO:0000250|UniProtKB:P61374}.		atrial septum morphogenesis [GO:0060413]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cardiac cell fate determination [GO:0060913]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac right ventricle morphogenesis [GO:0003215]; cellular response to glucocorticoid stimulus [GO:0071385]; endocardial cushion morphogenesis [GO:0003203]; heart development [GO:0007507]; innervation [GO:0060384]; mesenchymal cell differentiation [GO:0048762]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response [GO:0050728]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuron fate specification [GO:0048665]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pancreas development [GO:0031016]; peripheral nervous system neuron axonogenesis [GO:0048936]; pharyngeal system development [GO:0060037]; pituitary gland development [GO:0021983]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage colony-stimulating factor production [GO:1901258]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; retinal ganglion cell axon guidance [GO:0031290]; secondary heart field specification [GO:0003139]; sensory system development [GO:0048880]; sinoatrial node cell development [GO:0060931]; spinal cord motor neuron cell fate specification [GO:0021520]; spinal cord motor neuron differentiation [GO:0021522]; transcription by RNA polymerase II [GO:0006366]; trigeminal nerve development [GO:0021559]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visceral motor neuron differentiation [GO:0021524]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; atrial septum morphogenesis [GO:0060413]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cardiac cell fate determination [GO:0060913]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac right ventricle morphogenesis [GO:0003215]; cellular response to glucocorticoid stimulus [GO:0071385]; endocardial cushion morphogenesis [GO:0003203]; heart development [GO:0007507]; innervation [GO:0060384]; mesenchymal cell differentiation [GO:0048762]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response [GO:0050728]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuron fate specification [GO:0048665]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pancreas development [GO:0031016]; peripheral nervous system neuron axonogenesis [GO:0048936]; pharyngeal system development [GO:0060037]; pituitary gland development [GO:0021983]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage colony-stimulating factor production [GO:1901258]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; retinal ganglion cell axon guidance [GO:0031290]; secondary heart field specification [GO:0003139]; sensory system development [GO:0048880]; sinoatrial node cell development [GO:0060931]; spinal cord motor neuron cell fate specification [GO:0021520]; spinal cord motor neuron differentiation [GO:0021522]; transcription by RNA polymerase II [GO:0006366]; trigeminal nerve development [GO:0021559]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visceral motor neuron differentiation [GO:0021524]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P61372}.
P61421	reviewed	VA0D1_HUMAN	V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1)	ATP6V0D1 ATP6D VPATPD	Homo sapiens (Human)	351	FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002, PubMed:28296633, PubMed:30374053). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:30374053). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). {ECO:0000250|UniProtKB:P51863, ECO:0000250|UniProtKB:Q6PGV1, ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:30374053, ECO:0000269|PubMed:33065002}.		cellular response to increased oxygen levels [GO:0036295]; cilium assembly [GO:0060271]; intracellular iron ion homeostasis [GO:0006879]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]; vacuolar transport [GO:0007034]	apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; clathrin-coated vesicle membrane [GO:0030665]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane proton-transporting V-type ATPase complex [GO:0033181]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	protein-containing complex binding [GO:0044877]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; clathrin-coated vesicle membrane [GO:0030665]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane proton-transporting V-type ATPase complex [GO:0033181]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; protein-containing complex binding [GO:0044877]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; cellular response to increased oxygen levels [GO:0036295]; cilium assembly [GO:0060271]; intracellular iron ion homeostasis [GO:0006879]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]; vacuolar transport [GO:0007034]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:21844891}; Peripheral membrane protein {ECO:0000305|PubMed:21844891}; Cytoplasmic side {ECO:0000305|PubMed:21844891}. Lysosome membrane {ECO:0000305|PubMed:30374053}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P61420}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250|UniProtKB:Q6PGV1}.
P61457	reviewed	PHS_HUMAN	Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD)	PCBD1 DCOH PCBD	Homo sapiens (Human)	104	FUNCTION: Involved in tetrahydrobiopterin biosynthesis (By similarity). Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription (By similarity). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Also acts as a coactivator for HNF1B-dependent transcription (PubMed:24204001). {ECO:0000250|UniProtKB:P61459, ECO:0000269|PubMed:24204001}.		tetrahydrobiopterin biosynthetic process [GO:0006729]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	4-alpha-hydroxytetrahydrobiopterin dehydratase activity [GO:0008124]; identical protein binding [GO:0042802]; phenylalanine 4-monooxygenase activity [GO:0004505]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; 4-alpha-hydroxytetrahydrobiopterin dehydratase activity [GO:0008124]; identical protein binding [GO:0042802]; phenylalanine 4-monooxygenase activity [GO:0004505]; transcription coactivator activity [GO:0003713]; tetrahydrobiopterin biosynthetic process [GO:0006729]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24204001}. Nucleus {ECO:0000269|PubMed:24204001}. Note=Recruited to the nucleus through the interaction with HNF1B. {ECO:0000269|PubMed:24204001}.
P61513	reviewed	RL37A_HUMAN	Large ribosomal subunit protein eL43 (60S ribosomal protein L37a)	RPL37A	Homo sapiens (Human)	92	FUNCTION: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; synapse [GO:0045202]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; synapse [GO:0045202]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P61586	reviewed	RHOA_HUMAN	Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)	RHOA ARH12 ARHA RHO12	Homo sapiens (Human)	193	FUNCTION: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle (PubMed:23871831). Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers (PubMed:8910519, PubMed:9121475, PubMed:31570889). Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (PubMed:16236794, PubMed:12900402). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:20974804, PubMed:23940119). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695). Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (PubMed:31888991). May be an activator of PLCE1 (PubMed:16103226). In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). {ECO:0000250|UniProtKB:P61589, ECO:0000250|UniProtKB:Q9QUI0, ECO:0000269|PubMed:12900402, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:19403695, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:23871831, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:31570889, ECO:0000269|PubMed:31888991, ECO:0000269|PubMed:8910519, ECO:0000269|PubMed:9121475, ECO:0000269|PubMed:9635436}.; FUNCTION: (Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague. {ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863}.		actin cytoskeleton organization [GO:0030036]; alpha-beta T cell lineage commitment [GO:0002363]; androgen receptor signaling pathway [GO:0030521]; angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001998]; aortic valve formation [GO:0003189]; apical junction assembly [GO:0043297]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; beta selection [GO:0043366]; cell junction assembly [GO:0034329]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-matrix adhesion [GO:0007160]; cellular response to chemokine [GO:1990869]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cerebral cortex cell migration [GO:0021795]; cleavage furrow formation [GO:0036089]; cytoplasmic microtubule organization [GO:0031122]; endothelial cell migration [GO:0043542]; endothelial tube lumen extension [GO:0097498]; establishment of epithelial cell apical/basal polarity [GO:0045198]; forebrain radial glial cell differentiation [GO:0021861]; kidney development [GO:0001822]; mitotic cleavage furrow formation [GO:1903673]; mitotic spindle assembly [GO:0090307]; motor neuron apoptotic process [GO:0097049]; negative chemotaxis [GO:0050919]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell size [GO:0045792]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron migration [GO:0001764]; odontogenesis [GO:0042476]; ossification involved in bone maturation [GO:0043931]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokinesis [GO:0032467]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of lipase activity [GO:0060193]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular associated smooth muscle contraction [GO:1904695]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of neuron projection development [GO:0010975]; regulation of osteoblast proliferation [GO:0033688]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of transcription by RNA polymerase II [GO:0006357]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385]; skeletal muscle satellite cell migration [GO:1902766]; skeletal muscle tissue development [GO:0007519]; stress fiber assembly [GO:0043149]; substantia nigra development [GO:0021762]; substrate adhesion-dependent cell spreading [GO:0034446]; trabecula morphogenesis [GO:0061383]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing, spreading of cells [GO:0044319]	apical junction complex [GO:0043296]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cleavage furrow [GO:0032154]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; ruffle membrane [GO:0032587]; secretory granule membrane [GO:0030667]; vesicle [GO:0031982]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin binding [GO:0017022]; protein kinase binding [GO:0019901]	apical junction complex [GO:0043296]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cleavage furrow [GO:0032154]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; ruffle membrane [GO:0032587]; secretory granule membrane [GO:0030667]; vesicle [GO:0031982]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin binding [GO:0017022]; protein kinase binding [GO:0019901]; actin cytoskeleton organization [GO:0030036]; alpha-beta T cell lineage commitment [GO:0002363]; androgen receptor signaling pathway [GO:0030521]; angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001998]; aortic valve formation [GO:0003189]; apical junction assembly [GO:0043297]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; beta selection [GO:0043366]; cell junction assembly [GO:0034329]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-matrix adhesion [GO:0007160]; cellular response to chemokine [GO:1990869]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cerebral cortex cell migration [GO:0021795]; cleavage furrow formation [GO:0036089]; cytoplasmic microtubule organization [GO:0031122]; endothelial cell migration [GO:0043542]; endothelial tube lumen extension [GO:0097498]; establishment of epithelial cell apical/basal polarity [GO:0045198]; forebrain radial glial cell differentiation [GO:0021861]; kidney development [GO:0001822]; mitotic cleavage furrow formation [GO:1903673]; mitotic spindle assembly [GO:0090307]; motor neuron apoptotic process [GO:0097049]; negative chemotaxis [GO:0050919]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell size [GO:0045792]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron migration [GO:0001764]; odontogenesis [GO:0042476]; ossification involved in bone maturation [GO:0043931]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokinesis [GO:0032467]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of lipase activity [GO:0060193]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular associated smooth muscle contraction [GO:1904695]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of neuron projection development [GO:0010975]; regulation of osteoblast proliferation [GO:0033688]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of transcription by RNA polymerase II [GO:0006357]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385]; skeletal muscle satellite cell migration [GO:1902766]; skeletal muscle tissue development [GO:0007519]; stress fiber assembly [GO:0043149]; substantia nigra development [GO:0021762]; substrate adhesion-dependent cell spreading [GO:0034446]; trabecula morphogenesis [GO:0061383]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex {ECO:0000269|PubMed:9635436}. Midbody. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9QUI0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QUI0}. Nucleus {ECO:0000269|PubMed:12551911}. Cytoplasm {ECO:0000269|PubMed:23871831}. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner. {ECO:0000250|UniProtKB:Q9QUI0}.
P61587	reviewed	RND3_HUMAN	Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3)	RND3 ARHE RHO8 RHOE	Homo sapiens (Human)	244	FUNCTION: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.		actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein.
P61599	reviewed	NAA20_HUMAN	N-alpha-acetyltransferase 20 (EC 2.3.1.254) (Methionine N-acetyltransferase) (N-acetyltransferase 5) (N-terminal acetyltransferase B complex catalytic subunit NAA20) (N-terminal acetyltransferase B complex catalytic subunit NAT5) (NatB complex subunit NAT5) (NatB catalytic subunit)	NAA20 NAT5	Homo sapiens (Human)	178	FUNCTION: Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln (PubMed:34230638). Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration. {ECO:0000269|PubMed:18570629, ECO:0000269|PubMed:34230638}.		N-terminal peptidyl-aspartic acid acetylation [GO:0017190]; N-terminal peptidyl-glutamic acid acetylation [GO:0018002]; N-terminal peptidyl-glutamine acetylation [GO:0017192]; N-terminal protein amino acid acetylation [GO:0006474]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatB complex [GO:0031416]; nucleus [GO:0005634]	peptide alpha-N-acetyltransferase activity [GO:0004596]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatB complex [GO:0031416]; nucleus [GO:0005634]; peptide alpha-N-acetyltransferase activity [GO:0004596]; N-terminal peptidyl-aspartic acid acetylation [GO:0017190]; N-terminal peptidyl-glutamic acid acetylation [GO:0018002]; N-terminal peptidyl-glutamine acetylation [GO:0017192]; N-terminal protein amino acid acetylation [GO:0006474]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18570629, ECO:0000269|PubMed:25732826}. Nucleus {ECO:0000269|PubMed:18570629, ECO:0000269|PubMed:25732826}.
P61601	reviewed	NCALD_HUMAN	Neurocalcin-delta	NCALD	Homo sapiens (Human)	193	FUNCTION: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.		calcium-mediated signaling [GO:0019722]; regulation of systemic arterial blood pressure [GO:0003073]; vesicle-mediated transport [GO:0016192]	clathrin coat of trans-Golgi network vesicle [GO:0030130]; cytosol [GO:0005829]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; calcium ion binding [GO:0005509]; clathrin binding [GO:0030276]; tubulin binding [GO:0015631]	clathrin coat of trans-Golgi network vesicle [GO:0030130]; cytosol [GO:0005829]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; calcium ion binding [GO:0005509]; clathrin binding [GO:0030276]; tubulin binding [GO:0015631]; calcium-mediated signaling [GO:0019722]; regulation of systemic arterial blood pressure [GO:0003073]; vesicle-mediated transport [GO:0016192]	
P61604	reviewed	CH10_HUMAN	10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF)	HSPE1	Homo sapiens (Human)	102	FUNCTION: Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; chaperone cofactor-dependent protein refolding [GO:0051085]; osteoblast differentiation [GO:0001649]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; chaperone cofactor-dependent protein refolding [GO:0051085]; osteoblast differentiation [GO:0001649]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P61619	reviewed	S61A1_HUMAN	Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)	SEC61A1 SEC61A	Homo sapiens (Human)	476	FUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939, PubMed:22375059, PubMed:28782633, PubMed:29719251, PubMed:32814900). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:8616892). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity). {ECO:0000250|UniProtKB:P61620, ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:28782633, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:32814900, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522, ECO:0000269|PubMed:8616892}.		cotranslational protein targeting to membrane [GO:0006613]; endoplasmic reticulum organization [GO:0007029]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]; pronephric nephron development [GO:0039019]; protein insertion into ER membrane [GO:0045048]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; Sec61 translocon complex [GO:0005784]	calcium channel activity [GO:0005262]; protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022]; signal sequence binding [GO:0005048]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; Sec61 translocon complex [GO:0005784]; calcium channel activity [GO:0005262]; protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022]; signal sequence binding [GO:0005048]; cotranslational protein targeting to membrane [GO:0006613]; endoplasmic reticulum organization [GO:0007029]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]; pronephric nephron development [GO:0039019]; protein insertion into ER membrane [GO:0045048]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:27392076, ECO:0000269|PubMed:32814900, ECO:0000269|PubMed:36261522, ECO:0000269|PubMed:8616892}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes exclusively in granular structures in the endoplasmic reticulum (ER). {ECO:0000269|PubMed:27392076}.
P61626	reviewed	LYSC_HUMAN	Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C)	LYZ LZM	Homo sapiens (Human)	148	FUNCTION: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.	MISCELLANEOUS: Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.	antimicrobial humoral response [GO:0019730]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; killing of cells of another organism [GO:0031640]; metabolic process [GO:0008152]; retina homeostasis [GO:0001895]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	identical protein binding [GO:0042802]; lysozyme activity [GO:0003796]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; identical protein binding [GO:0042802]; lysozyme activity [GO:0003796]; antimicrobial humoral response [GO:0019730]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; killing of cells of another organism [GO:0031640]; metabolic process [GO:0008152]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Secreted.
P61647	reviewed	SIA8F_HUMAN	Alpha-2,8-sialyltransferase 8F (EC 2.4.99.-) (Sialyltransferase 8F) (SIAT8-F) (Sialyltransferase St8Sia VI) (ST8SiaVI)	ST8SIA6 SIAT8F	Homo sapiens (Human)	398	FUNCTION: Alpha-2,8-sialyltransferase that prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups. {ECO:0000250|UniProtKB:Q8K4T1}.		blastocyst hatching [GO:0001835]; carbohydrate biosynthetic process [GO:0016051]; ganglioside biosynthetic process [GO:0001574]; glycolipid biosynthetic process [GO:0009247]; glycoprotein metabolic process [GO:0009100]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialyltransferase activity [GO:0008373]	Golgi membrane [GO:0000139]; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialyltransferase activity [GO:0008373]; blastocyst hatching [GO:0001835]; carbohydrate biosynthetic process [GO:0016051]; ganglioside biosynthetic process [GO:0001574]; glycolipid biosynthetic process [GO:0009247]; glycoprotein metabolic process [GO:0009100]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
P61758	reviewed	PFD3_HUMAN	Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1)	VBP1 PFDN3	Homo sapiens (Human)	197	FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.		chaperone-mediated protein folding [GO:0061077]; microtubule-based process [GO:0007017]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; polysome [GO:0005844]; prefoldin complex [GO:0016272]	amyloid-beta binding [GO:0001540]; tubulin binding [GO:0015631]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; polysome [GO:0005844]; prefoldin complex [GO:0016272]; amyloid-beta binding [GO:0001540]; tubulin binding [GO:0015631]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]; microtubule-based process [GO:0007017]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus.
P61764	reviewed	STXB1_HUMAN	Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)	STXBP1 UNC18A	Homo sapiens (Human)	594	FUNCTION: Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synapic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. {ECO:0000250|UniProtKB:O08599, ECO:0000250|UniProtKB:P61765}.		axon target recognition [GO:0007412]; cellular response to type II interferon [GO:0071346]; developmental process involved in reproduction [GO:0003006]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; neuromuscular synaptic transmission [GO:0007274]; neuron apoptotic process [GO:0051402]; neurotransmitter secretion [GO:0007269]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of glutamate secretion, neurotransmission [GO:1903296]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of vesicle docking [GO:0106022]; presynaptic dense core vesicle exocytosis [GO:0099525]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of acrosomal vesicle exocytosis [GO:2000367]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; regulation of synaptic vesicle priming [GO:0010807]; response to estradiol [GO:0032355]; SNARE complex assembly [GO:0035493]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle priming [GO:0016082]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of presynaptic membrane [GO:0098888]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; parallel fiber to Purkinje cell synapse [GO:0098688]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; postsynapse [GO:0098794]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic active zone membrane [GO:0048787]; presynaptic cytosol [GO:0099523]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]	identical protein binding [GO:0042802]; phospholipase binding [GO:0043274]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of presynaptic membrane [GO:0098888]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; parallel fiber to Purkinje cell synapse [GO:0098688]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; postsynapse [GO:0098794]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic active zone membrane [GO:0048787]; presynaptic cytosol [GO:0099523]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; identical protein binding [GO:0042802]; phospholipase binding [GO:0043274]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]; axon target recognition [GO:0007412]; cellular response to type II interferon [GO:0071346]; developmental process involved in reproduction [GO:0003006]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; neuromuscular synaptic transmission [GO:0007274]; neuron apoptotic process [GO:0051402]; neurotransmitter secretion [GO:0007269]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of glutamate secretion, neurotransmission [GO:1903296]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of vesicle docking [GO:0106022]; presynaptic dense core vesicle exocytosis [GO:0099525]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of acrosomal vesicle exocytosis [GO:2000367]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; regulation of synaptic vesicle priming [GO:0010807]; response to estradiol [GO:0032355]; SNARE complex assembly [GO:0035493]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle priming [GO:0016082]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20887364}. Membrane; Peripheral membrane protein.
P61769	reviewed	B2MG_HUMAN	Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]	B2M CDABP0092 HDCMA22P	Homo sapiens (Human)	119	FUNCTION: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}.		amyloid fibril formation [GO:1990000]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; cellular response to iron ion [GO:0071281]; cellular response to iron(III) ion [GO:0071283]; cellular response to nicotine [GO:0071316]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; learning or memory [GO:0007611]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of forebrain neuron differentiation [GO:2000978]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron projection development [GO:0010977]; negative regulation of receptor binding [GO:1900121]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of cellular senescence [GO:2000774]; positive regulation of ferrous iron binding [GO:1904434]; positive regulation of immune response [GO:0050778]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor binding [GO:1900122]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transferrin receptor binding [GO:1904437]; protein homotetramerization [GO:0051289]; protein refolding [GO:0042026]; regulation of erythrocyte differentiation [GO:0045646]; regulation of iron ion transport [GO:0034756]; response to molecule of bacterial origin [GO:0002237]; retina homeostasis [GO:0001895]; sensory perception of smell [GO:0007608]; T cell differentiation in thymus [GO:0033077]; T cell mediated cytotoxicity [GO:0001913]	cytosol [GO:0005829]; early endosome lumen [GO:0031905]; early endosome membrane [GO:0031901]; endoplasmic reticulum lumen [GO:0005788]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; HFE-transferrin receptor complex [GO:1990712]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; MHC class I protein complex [GO:0042612]; MHC class II protein complex [GO:0042613]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	identical protein binding [GO:0042802]; MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; early endosome lumen [GO:0031905]; early endosome membrane [GO:0031901]; endoplasmic reticulum lumen [GO:0005788]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; HFE-transferrin receptor complex [GO:1990712]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; MHC class I protein complex [GO:0042612]; MHC class II protein complex [GO:0042613]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; identical protein binding [GO:0042802]; MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]; protein homodimerization activity [GO:0042803]; amyloid fibril formation [GO:1990000]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; cellular response to iron ion [GO:0071281]; cellular response to iron(III) ion [GO:0071283]; cellular response to nicotine [GO:0071316]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; learning or memory [GO:0007611]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of forebrain neuron differentiation [GO:2000978]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron projection development [GO:0010977]; negative regulation of receptor binding [GO:1900121]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of cellular senescence [GO:2000774]; positive regulation of ferrous iron binding [GO:1904434]; positive regulation of immune response [GO:0050778]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor binding [GO:1900122]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transferrin receptor binding [GO:1904437]; protein homotetramerization [GO:0051289]; protein refolding [GO:0042026]; regulation of erythrocyte differentiation [GO:0045646]; regulation of iron ion transport [GO:0034756]; response to molecule of bacterial origin [GO:0002237]; retina homeostasis [GO:0001895]; sensory perception of smell [GO:0007608]; T cell differentiation in thymus [GO:0033077]; T cell mediated cytotoxicity [GO:0001913]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1336137, ECO:0000269|PubMed:7554280}. Cell surface {ECO:0000269|PubMed:25356553}. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). {ECO:0000269|PubMed:7554280, ECO:0000269|Ref.6}.; SUBCELLULAR LOCATION: Note=(Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553). {ECO:0000269|PubMed:25356553}.
P61803	reviewed	DAD1_HUMAN	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) (Defender against cell death 1) (DAD-1)	DAD1	Homo sapiens (Human)	113	FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853, PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes. Loss of the DAD1 protein triggers apoptosis (PubMed:22467853). {ECO:0000250|UniProtKB:E2R4X3, ECO:0000269|PubMed:22467853, ECO:0000269|PubMed:31831667}.		apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; negative regulation of apoptotic process [GO:0043066]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; regulation of protein stability [GO:0031647]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]	enzyme activator activity [GO:0008047]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; enzyme activator activity [GO:0008047]; apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; negative regulation of apoptotic process [GO:0043066]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000305}.
P61812	reviewed	TGFB2_HUMAN	Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]	TGFB2	Homo sapiens (Human)	414	FUNCTION: [Transforming growth factor beta-2 proprotein]: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. {ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202}.; FUNCTION: [Latency-associated peptide]: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 (By similarity). {ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202}.; FUNCTION: [Transforming growth factor beta-2]: Multifunctional protein that regulates various processes such as angiogenesis and heart development (PubMed:22772371, PubMed:22772368). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). {ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202, ECO:0000269|PubMed:22772368, ECO:0000269|PubMed:22772371}.		activation of protein kinase activity [GO:0032147]; ascending aorta morphogenesis [GO:0035910]; atrial septum morphogenesis [GO:0060413]; atrial septum primum morphogenesis [GO:0003289]; atrioventricular valve morphogenesis [GO:0003181]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell proliferation [GO:0060038]; cardiac right ventricle morphogenesis [GO:0003215]; cardioblast differentiation [GO:0010002]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell junction organization [GO:0045216]; collagen fibril organization [GO:0030199]; cranial skeletal system development [GO:1904888]; dopamine biosynthetic process [GO:0042416]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digestive tract development [GO:0048566]; embryonic limb morphogenesis [GO:0030326]; endocardial cushion fusion [GO:0003274]; endocardial cushion morphogenesis [GO:0003203]; epithelial to mesenchymal transition [GO:0001837]; extrinsic apoptotic signaling pathway [GO:0097191]; eye development [GO:0001654]; generation of neurons [GO:0048699]; glial cell migration [GO:0008347]; hair follicle development [GO:0001942]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; hemopoiesis [GO:0030097]; inner ear development [GO:0048839]; kidney development [GO:0001822]; male gonad development [GO:0008584]; membranous septum morphogenesis [GO:0003149]; negative regulation of alkaline phosphatase activity [GO:0010693]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905006]; negative regulation of gene expression [GO:0010629]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of Ras protein signal transduction [GO:0046580]; neural retina development [GO:0003407]; neural tube closure [GO:0001843]; neuron development [GO:0048666]; neutrophil chemotaxis [GO:0030593]; odontogenesis [GO:0042476]; outflow tract septum morphogenesis [GO:0003148]; pharyngeal arch artery morphogenesis [GO:0061626]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell division [GO:0051781]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of heart contraction [GO:0045823]; positive regulation of immune response [GO:0050778]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein secretion [GO:0050714]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of timing of catagen [GO:0051795]; protein phosphorylation [GO:0006468]; pulmonary valve morphogenesis [GO:0003184]; regulation of apoptotic process involved in outflow tract morphogenesis [GO:1902256]; regulation of cell population proliferation [GO:0042127]; regulation of timing of catagen [GO:0051794]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; salivary gland morphogenesis [GO:0007435]; secondary palate development [GO:0062009]; signaling [GO:0023052]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395]; somatic stem cell division [GO:0048103]; substantia propria of cornea development [GO:1903701]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterine wall breakdown [GO:0042704]; uterus development [GO:0060065]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060]	axon [GO:0030424]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; platelet alpha granule lumen [GO:0031093]	amyloid-beta binding [GO:0001540]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; transforming growth factor beta receptor binding [GO:0005160]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714]	axon [GO:0030424]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; platelet alpha granule lumen [GO:0031093]; amyloid-beta binding [GO:0001540]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; transforming growth factor beta receptor binding [GO:0005160]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714]; activation of protein kinase activity [GO:0032147]; ascending aorta morphogenesis [GO:0035910]; atrial septum morphogenesis [GO:0060413]; atrial septum primum morphogenesis [GO:0003289]; atrioventricular valve morphogenesis [GO:0003181]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell proliferation [GO:0060038]; cardiac right ventricle morphogenesis [GO:0003215]; cardioblast differentiation [GO:0010002]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell junction organization [GO:0045216]; collagen fibril organization [GO:0030199]; cranial skeletal system development [GO:1904888]; dopamine biosynthetic process [GO:0042416]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digestive tract development [GO:0048566]; embryonic limb morphogenesis [GO:0030326]; endocardial cushion fusion [GO:0003274]; endocardial cushion morphogenesis [GO:0003203]; epithelial to mesenchymal transition [GO:0001837]; extrinsic apoptotic signaling pathway [GO:0097191]; eye development [GO:0001654]; generation of neurons [GO:0048699]; glial cell migration [GO:0008347]; hair follicle development [GO:0001942]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; hemopoiesis [GO:0030097]; inner ear development [GO:0048839]; kidney development [GO:0001822]; male gonad development [GO:0008584]; membranous septum morphogenesis [GO:0003149]; negative regulation of alkaline phosphatase activity [GO:0010693]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905006]; negative regulation of gene expression [GO:0010629]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of Ras protein signal transduction [GO:0046580]; neural retina development [GO:0003407]; neural tube closure [GO:0001843]; neuron development [GO:0048666]; neutrophil chemotaxis [GO:0030593]; odontogenesis [GO:0042476]; outflow tract septum morphogenesis [GO:0003148]; pharyngeal arch artery morphogenesis [GO:0061626]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell division [GO:0051781]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of heart contraction [GO:0045823]; positive regulation of immune response [GO:0050778]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein secretion [GO:0050714]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of timing of catagen [GO:0051795]; protein phosphorylation [GO:0006468]; pulmonary valve morphogenesis [GO:0003184]; regulation of apoptotic process involved in outflow tract morphogenesis [GO:1902256]; regulation of cell population proliferation [GO:0042127]; regulation of timing of catagen [GO:0051794]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; salivary gland morphogenesis [GO:0007435]; secondary palate development [GO:0062009]; signaling [GO:0023052]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395]; somatic stem cell division [GO:0048103]; substantia propria of cornea development [GO:1903701]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterine wall breakdown [GO:0042704]; uterus development [GO:0060065]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137}.; SUBCELLULAR LOCATION: [Transforming growth factor beta-2]: Secreted {ECO:0000250|UniProtKB:P01137}.
P61916	reviewed	NPC2_HUMAN	NPC intracellular cholesterol transporter 2 (Epididymal secretory protein E1) (Human epididymis-specific protein 1) (He1) (Niemann-Pick disease type C2 protein)	NPC2 HE1	Homo sapiens (Human)	151	FUNCTION: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:17018531, PubMed:11125141, PubMed:18772377, PubMed:29580834, PubMed:15937921). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity). {ECO:0000250|UniProtKB:Q9Z0J0, ECO:0000269|PubMed:11125141, ECO:0000269|PubMed:15937921, ECO:0000269|PubMed:17018531, ECO:0000269|PubMed:18772377, ECO:0000269|PubMed:18823126, ECO:0000269|PubMed:27238017, ECO:0000269|PubMed:29580834}.		cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; cholesterol transport [GO:0030301]; gene expression [GO:0010467]; glycolipid transport [GO:0046836]; intracellular cholesterol transport [GO:0032367]; intracellular sterol transport [GO:0032366]; phospholipid transport [GO:0015914]; regulation of isoprenoid metabolic process [GO:0019747]; response to virus [GO:0009615]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; cholesterol transport [GO:0030301]; gene expression [GO:0010467]; glycolipid transport [GO:0046836]; intracellular cholesterol transport [GO:0032367]; intracellular sterol transport [GO:0032366]; phospholipid transport [GO:0015914]; regulation of isoprenoid metabolic process [GO:0019747]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11125141, ECO:0000269|PubMed:15937921, ECO:0000269|PubMed:19723497, ECO:0000269|PubMed:21315718}. Endoplasmic reticulum {ECO:0000269|PubMed:19723497}. Lysosome {ECO:0000269|PubMed:15937921, ECO:0000269|PubMed:19723497, ECO:0000305|PubMed:11125141}. Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes. {ECO:0000305|PubMed:11125141}.
P61923	reviewed	COPZ1_HUMAN	Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP)	COPZ1 COPZ CGI-120 HSPC181	Homo sapiens (Human)	177	FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity). {ECO:0000250|UniProtKB:P53600}.		intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]		COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
P61925	reviewed	IPKA_HUMAN	cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform)	PKIA PRKACN1	Homo sapiens (Human)	76	FUNCTION: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.	MISCELLANEOUS: The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and 'pseudosubstrate site' of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site.	negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	cAMP-dependent protein kinase inhibitor activity [GO:0004862]; protein kinase A catalytic subunit binding [GO:0034236]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; protein kinase A catalytic subunit binding [GO:0034236]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]	
P61927	reviewed	RL37_HUMAN	Large ribosomal subunit protein eL37 (60S ribosomal protein L37) (G1.16)	RPL37	Homo sapiens (Human)	97	FUNCTION: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; synapse [GO:0045202]	MDM2/MDM4 family protein binding [GO:0097371]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; synapse [GO:0045202]; MDM2/MDM4 family protein binding [GO:0097371]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; cytoplasmic translation [GO:0002181]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P61952	reviewed	GBG11_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	GNG11 GNGT11	Homo sapiens (Human)	73	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.		G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]	heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]	G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]	heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P61956	reviewed	SUMO2_HUMAN	Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)	SUMO2 SMT3B SMT3H2	Homo sapiens (Human)	95	FUNCTION: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26524494, ECO:0000269|PubMed:9556629}.		positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein sumoylation [GO:0016925]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	protein tag activity [GO:0031386]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein tag activity [GO:0031386]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein sumoylation [GO:0016925]	SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body.
P61960	reviewed	UFM1_HUMAN	Ubiquitin-fold modifier 1	UFM1 C13orf20 BM-002	Homo sapiens (Human)	85	FUNCTION: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer (PubMed:15071506, PubMed:20018847, PubMed:29868776, PubMed:27653677). The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847, PubMed:29868776, PubMed:27653677). Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:32160526). Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription (PubMed:25219498). {ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29868776, ECO:0000269|PubMed:32160526}.		brain development [GO:0007420]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein import into nucleus [GO:0042308]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; brain development [GO:0007420]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein import into nucleus [GO:0042308]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15071506}. Cytoplasm {ECO:0000269|PubMed:15071506}.
P61962	reviewed	DCAF7_HUMAN	DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog)	DCAF7 HAN11 WDR68	Homo sapiens (Human)	342	FUNCTION: Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000250, ECO:0000269|PubMed:16887337, ECO:0000269|PubMed:16949367}.		protein ubiquitination [GO:0016567]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	protein-macromolecule adaptor activity [GO:0030674]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-macromolecule adaptor activity [GO:0030674]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.
P61964	reviewed	WDR5_HUMAN	WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)	WDR5 BIG3	Homo sapiens (Human)	334	FUNCTION: Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:P61965, ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:18840606, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.		gluconeogenesis [GO:0006094]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of histone H3-K4 methylation [GO:0051571]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; skeletal system development [GO:0001501]; transcription initiation-coupled chromatin remodeling [GO:0045815]	ATAC complex [GO:0140672]; histone acetyltransferase complex [GO:0000123]; histone methyltransferase complex [GO:0035097]; mitotic spindle [GO:0072686]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]	histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; methylated histone binding [GO:0035064]	ATAC complex [GO:0140672]; histone acetyltransferase complex [GO:0000123]; histone methyltransferase complex [GO:0035097]; mitotic spindle [GO:0072686]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]; histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; methylated histone binding [GO:0035064]; gluconeogenesis [GO:0006094]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of histone H3-K4 methylation [GO:0051571]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; skeletal system development [GO:0001501]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:34850113}.
P61966	reviewed	AP1S1_HUMAN	AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin)	AP1S1 AP19 CLAPS1	Homo sapiens (Human)	158	FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. {ECO:0000269|PubMed:9733768}.		basolateral protein secretion [GO:0110010]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; receptor-mediated endocytosis [GO:0006898]; response to virus [GO:0009615]; vesicle-mediated transport [GO:0016192]	AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588]	clathrin adaptor activity [GO:0035615]	AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588]; clathrin adaptor activity [GO:0035615]; basolateral protein secretion [GO:0110010]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; receptor-mediated endocytosis [GO:0006898]; response to virus [GO:0009615]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:9733768}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9733768}; Peripheral membrane protein {ECO:0000269|PubMed:9733768}; Cytoplasmic side {ECO:0000269|PubMed:9733768}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:9733768}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
P61968	reviewed	LMO4_HUMAN	LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)	LMO4	Homo sapiens (Human)	165	FUNCTION: Transcription cofactor. Plays a role in establishing motor neuron identity, in concert with MNX1, acting, at least in part, to disrupt LDB1-LHX3 complexes thereby negatively modulating interneuron genes in motor neurons. {ECO:0000250|UniProtKB:P61969}.		motor neuron axon guidance [GO:0008045]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of kinase activity [GO:0033674]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell activation [GO:0050865]; regulation of cell fate specification [GO:0042659]; regulation of cell migration [GO:0030334]; spinal cord association neuron differentiation [GO:0021527]; spinal cord motor neuron cell fate specification [GO:0021520]; thymus development [GO:0048538]; ventral spinal cord interneuron differentiation [GO:0021514]; ventricular septum development [GO:0003281]	cell leading edge [GO:0031252]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	cell leading edge [GO:0031252]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; motor neuron axon guidance [GO:0008045]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of kinase activity [GO:0033674]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell activation [GO:0050865]; regulation of cell fate specification [GO:0042659]; regulation of cell migration [GO:0030334]; spinal cord association neuron differentiation [GO:0021527]; spinal cord motor neuron cell fate specification [GO:0021520]; thymus development [GO:0048538]; ventral spinal cord interneuron differentiation [GO:0021514]; ventricular septum development [GO:0003281]	
P61970	reviewed	NTF2_HUMAN	Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15)	NUTF2 NTF2	Homo sapiens (Human)	127	FUNCTION: Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:7744965}.		mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein localization to nuclear pore [GO:0090204]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nuclear pore central transport channel [GO:0044613]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267]; structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nuclear pore central transport channel [GO:0044613]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267]; structural constituent of nuclear pore [GO:0017056]; mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein localization to nuclear pore [GO:0090204]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:7744965}. Nucleus outer membrane {ECO:0000250|UniProtKB:P61972}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P61972}. Nucleus inner membrane {ECO:0000250|UniProtKB:P61972}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10679025}. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. {ECO:0000269|PubMed:10679025}.
P61978	reviewed	HNRPK_HUMAN	Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)	HNRNPK HNRPK	Homo sapiens (Human)	463	FUNCTION: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}.		mRNA splicing, via spliceosome [GO:0000398]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902165]; regulation of low-density lipoprotein particle clearance [GO:0010988]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA processing [GO:0006396]; signal transduction [GO:0007165]	catalytic step 2 spliceosome [GO:0071013]; cell projection [GO:0042995]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102]; ribonucleoprotein complex [GO:1990904]	cadherin binding [GO:0045296]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cell projection [GO:0042995]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102]; ribonucleoprotein complex [GO:1990904]; cadherin binding [GO:0045296]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902165]; regulation of low-density lipoprotein particle clearance [GO:0010988]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA processing [GO:0006396]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1729596}. Nucleus, nucleoplasm {ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:1729596, ECO:0000269|PubMed:18775702, ECO:0000269|PubMed:22721921}. Cell projection, podosome {ECO:0000269|PubMed:22721921}. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53 (PubMed:16360036). In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear (PubMed:18775702).
P61981	reviewed	1433G_HUMAN	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]	YWHAG	Homo sapiens (Human)	247	FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:36732624}.		cellular response to glucose starvation [GO:0042149]; cellular response to insulin stimulus [GO:0032869]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TORC1 signaling [GO:1904262]; protein targeting [GO:0006605]; regulation of neuron differentiation [GO:0045664]; regulation of signal transduction [GO:0009966]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; presynapse [GO:0098793]	identical protein binding [GO:0042802]; insulin-like growth factor receptor binding [GO:0005159]; phosphoserine residue binding [GO:0050815]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; protein kinase C inhibitor activity [GO:0008426]; protein sequestering activity [GO:0140311]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; presynapse [GO:0098793]; identical protein binding [GO:0042802]; insulin-like growth factor receptor binding [GO:0005159]; phosphoserine residue binding [GO:0050815]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; protein kinase C inhibitor activity [GO:0008426]; protein sequestering activity [GO:0140311]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]; cellular response to glucose starvation [GO:0042149]; cellular response to insulin stimulus [GO:0032869]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TORC1 signaling [GO:1904262]; protein targeting [GO:0006605]; regulation of neuron differentiation [GO:0045664]; regulation of signal transduction [GO:0009966]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P68252}.
P62068	reviewed	UBP46_HUMAN	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46)	USP46	Homo sapiens (Human)	366	FUNCTION: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). {ECO:0000250|UniProtKB:P62069, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:26388029}.		adult feeding behavior [GO:0008343]; behavioral fear response [GO:0001662]; behavioral response to ethanol [GO:0048149]; protein deubiquitination [GO:0016579]; regulation of synaptic transmission, GABAergic [GO:0032228]; righting reflex [GO:0060013]	cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; metal ion binding [GO:0046872]; adult feeding behavior [GO:0008343]; behavioral fear response [GO:0001662]; behavioral response to ethanol [GO:0048149]; protein deubiquitination [GO:0016579]; regulation of synaptic transmission, GABAergic [GO:0032228]; righting reflex [GO:0060013]	
P62070	reviewed	RRAS2_HUMAN	Ras-related protein R-Ras2 (EC 3.6.5.-) (Ras-like protein TC21) (Teratocarcinoma oncogene)	RRAS2 TC21	Homo sapiens (Human)	204	FUNCTION: GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes (PubMed:31130282). Involved in the regulation of MAPK signaling pathway (PubMed:31130282, PubMed:31130285). Regulation of craniofacial development (PubMed:31130282, PubMed:31130285). {ECO:0000269|PubMed:31130282, ECO:0000269|PubMed:31130285}.		osteoblast differentiation [GO:0001649]; positive regulation of Schwann cell migration [GO:1900149]; Ras protein signal transduction [GO:0007265]; Schwann cell migration [GO:0036135]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; osteoblast differentiation [GO:0001649]; positive regulation of Schwann cell migration [GO:1900149]; Ras protein signal transduction [GO:0007265]; Schwann cell migration [GO:0036135]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28406396, ECO:0000269|PubMed:31130282}; Lipid-anchor {ECO:0000269|PubMed:15308774, ECO:0000269|PubMed:28406396}; Cytoplasmic side. Golgi apparatus membrane {ECO:0000269|PubMed:31130282}; Lipid-anchor {ECO:0000269|PubMed:15308774}.
P62072	reviewed	TIM10_HUMAN	Mitochondrial import inner membrane translocase subunit Tim10	TIMM10 TIM10	Homo sapiens (Human)	90	FUNCTION: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}.		protein insertion into mitochondrial inner membrane [GO:0045039]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	membrane insertase activity [GO:0032977]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; zinc ion binding [GO:0008270]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; membrane insertase activity [GO:0032977]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; zinc ion binding [GO:0008270]; protein insertion into mitochondrial inner membrane [GO:0045039]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Peripheral membrane protein {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Intermembrane side {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}.
P62079	reviewed	TSN5_HUMAN	Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)	TSPAN5 TM4SF9	Homo sapiens (Human)	268	FUNCTION: Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44. {ECO:0000269|PubMed:26686862}.		positive regulation of Notch signaling pathway [GO:0045747]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]	actin cytoskeleton [GO:0015629]; endoplasmic reticulum lumen [GO:0005788]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]	actin cytoskeleton [GO:0015629]; endoplasmic reticulum lumen [GO:0005788]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; positive regulation of Notch signaling pathway [GO:0045747]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862}; Multi-pass membrane protein {ECO:0000305}.
P62081	reviewed	RS7_HUMAN	Small ribosomal subunit protein eS7 (40S ribosomal protein S7)	RPS7	Homo sapiens (Human)	194	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for rRNA maturation (PubMed:19061985). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural crest cell differentiation [GO:0014033]; neural tube closure [GO:0001843]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; protein stabilization [GO:0050821]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202]	mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; cytoplasmic translation [GO:0002181]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural crest cell differentiation [GO:0014033]; neural tube closure [GO:0001843]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; protein stabilization [GO:0050821]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20873783}. Cytoplasm {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:9687515}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:9687515}. Note=Although RPS7 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPS7 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn (PubMed:9687515). Colocalizes with NEK6 in the centrosome (PubMed:20873783). {ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:9687515}.
P62136	reviewed	PP1A_HUMAN	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)	PPP1CA PPP1A	Homo sapiens (Human)	330	FUNCTION: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). {ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}.		beta-catenin destruction complex disassembly [GO:1904886]; branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; dephosphorylation [GO:0016311]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; lung development [GO:0030324]; negative regulation of protein binding [GO:0032091]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein dephosphorylation [GO:0006470]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of circadian rhythm [GO:0042752]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]; regulation of translational initiation by eIF2 alpha dephosphorylation [GO:0036496]; response to lead ion [GO:0010288]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; glycogen granule [GO:0042587]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; PTW/PP1 phosphatase complex [GO:0072357]	cadherin binding involved in cell-cell adhesion [GO:0098641]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase activity [GO:0004722]; ribonucleoprotein complex binding [GO:0043021]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; glycogen granule [GO:0042587]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; PTW/PP1 phosphatase complex [GO:0072357]; cadherin binding involved in cell-cell adhesion [GO:0098641]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase activity [GO:0004722]; ribonucleoprotein complex binding [GO:0043021]; beta-catenin destruction complex disassembly [GO:1904886]; branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; dephosphorylation [GO:0016311]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; lung development [GO:0030324]; negative regulation of protein binding [GO:0032091]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein dephosphorylation [GO:0006470]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of circadian rhythm [GO:0042752]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]; regulation of translational initiation by eIF2 alpha dephosphorylation [GO:0036496]; response to lead ion [GO:0010288]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:29769351}. Nucleus {ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:17965019}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:17965019}. Nucleus, nucleolus {ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:17965019}. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. Shuttles toward the cytosol during infection with VEEV (PubMed:29769351). {ECO:0000269|PubMed:29769351}.
P62140	reviewed	PP1B_HUMAN	Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)	PPP1CB	Homo sapiens (Human)	327	FUNCTION: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208}.		cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; MAPK cascade [GO:0000165]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glycogen granule [GO:0042587]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; myosin-light-chain-phosphatase activity [GO:0050115]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glycogen granule [GO:0042587]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; myosin-light-chain-phosphatase activity [GO:0050115]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; protein serine/threonine phosphatase activity [GO:0004722]; cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; MAPK cascade [GO:0000165]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11739654}. Nucleus {ECO:0000269|PubMed:11739654}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11739654}. Nucleus, nucleolus {ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:20926688}. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. {ECO:0000269|PubMed:11739654}.
P62166	reviewed	NCS1_HUMAN	Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein)	NCS1 FLUP FREQ	Homo sapiens (Human)	190	FUNCTION: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity). {ECO:0000250}.	MISCELLANEOUS: Binds 3 calcium ions via the second, third and fourth EF-hand.	regulation of neuron projection development [GO:0010975]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]; voltage-gated calcium channel activity [GO:0005245]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]; voltage-gated calcium channel activity [GO:0005245]; regulation of neuron projection development [GO:0010975]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:17555535}. Postsynaptic density {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11092894, ECO:0000269|PubMed:17555535}. Cytoplasm {ECO:0000250|UniProtKB:P62168}. Cell membrane {ECO:0000269|PubMed:17555535}; Peripheral membrane protein. Membrane {ECO:0000250|UniProtKB:P62168}; Lipid-anchor {ECO:0000305}. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. {ECO:0000305, ECO:0000305|PubMed:17555535}.
P62191	reviewed	PRS4_HUMAN	26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)	PSMC1	Homo sapiens (Human)	440	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]; RNA binding [GO:0003723]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]; RNA binding [GO:0003723]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
P62195	reviewed	PRS8_HUMAN	26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)	PSMC5 SUG1	Homo sapiens (Human)	406	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of programmed cell death [GO:0043069]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteasomal protein catabolic process [GO:1901800]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription by RNA polymerase II [GO:0006357]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA-binding transcription factor binding [GO:0140297]; general transcription initiation factor binding [GO:0140296]; proteasome-activating activity [GO:0036402]; thyrotropin-releasing hormone receptor binding [GO:0031531]; transcription factor binding [GO:0008134]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA-binding transcription factor binding [GO:0140297]; general transcription initiation factor binding [GO:0140296]; proteasome-activating activity [GO:0036402]; thyrotropin-releasing hormone receptor binding [GO:0031531]; transcription factor binding [GO:0008134]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of programmed cell death [GO:0043069]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteasomal protein catabolic process [GO:1901800]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
P62241	reviewed	RS8_HUMAN	Small ribosomal subunit protein eS8 (40S ribosomal protein S8)	RPS8 OK/SW-cl.83	Homo sapiens (Human)	208	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:23636399}. Membrane {ECO:0000305|PubMed:17289661}; Lipid-anchor {ECO:0000305|PubMed:17289661}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:17289661}.
P62244	reviewed	RS15A_HUMAN	Small ribosomal subunit protein uS8 (40S ribosomal protein S15a)	RPS15A OK/SW-cl.82	Homo sapiens (Human)	130	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Required for proper erythropoiesis (PubMed:27909223). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:27909223, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; response to virus [GO:0009615]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; synapse [GO:0045202]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; response to virus [GO:0009615]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
P62249	reviewed	RS16_HUMAN	Small ribosomal subunit protein uS9 (40S ribosomal protein S16)	RPS16	Homo sapiens (Human)	146	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		cellular response to leukemia inhibitory factor [GO:1990830]; cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; synapse [GO:0045202]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular response to leukemia inhibitory factor [GO:1990830]; cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
P62253	reviewed	UB2G1_HUMAN	Ubiquitin-conjugating enzyme E2 G1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G1) (E217K) (UBC7) (Ubiquitin carrier protein G1) (Ubiquitin-protein ligase G1) [Cleaved into: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed]	UBE2G1 UBE2G	Homo sapiens (Human)	170	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. {ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:20061386}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; ubiquitin-dependent protein catabolic process [GO:0006511]	
P62256	reviewed	UBE2H_HUMAN	Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)	UBE2H	Homo sapiens (Human)	183	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:8132613, PubMed:17588522, PubMed:20061386). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination (PubMed:20061386). Capable, in vitro, to ubiquitinate histone H2A (PubMed:8132613). {ECO:0000269|PubMed:17588522, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:29911972, ECO:0000269|PubMed:8132613}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]	
P62258	reviewed	1433E_HUMAN	14-3-3 protein epsilon (14-3-3E)	YWHAE	Homo sapiens (Human)	255	FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326}.	MISCELLANEOUS: [Isoform SV]: Unable to dimerize with YWHAZ. {ECO:0000305}.	cellular response to heat [GO:0034605]; cerebral cortex development [GO:0021987]; hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; negative regulation of calcium ion export across plasma membrane [GO:1905913]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of peptidyl-serine dephosphorylation [GO:1902309]; neuron migration [GO:0001764]; positive regulation of protein export from nucleus [GO:0046827]; protein localization to nucleus [GO:0034504]; protein targeting [GO:0006605]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of heart rate by hormone [GO:0003064]; regulation of membrane repolarization [GO:0060306]; regulation of mitotic cell cycle [GO:0007346]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; calcium channel regulator activity [GO:0005246]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; MHC class II protein complex binding [GO:0023026]; phosphoprotein binding [GO:0051219]; phosphoserine residue binding [GO:0050815]; potassium channel regulator activity [GO:0015459]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; calcium channel regulator activity [GO:0005246]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; MHC class II protein complex binding [GO:0023026]; phosphoprotein binding [GO:0051219]; phosphoserine residue binding [GO:0050815]; potassium channel regulator activity [GO:0015459]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; cellular response to heat [GO:0034605]; cerebral cortex development [GO:0021987]; hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; negative regulation of calcium ion export across plasma membrane [GO:1905913]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of peptidyl-serine dephosphorylation [GO:1902309]; neuron migration [GO:0001764]; positive regulation of protein export from nucleus [GO:0046827]; protein localization to nucleus [GO:0034504]; protein targeting [GO:0006605]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of heart rate by hormone [GO:0003064]; regulation of membrane repolarization [GO:0060306]; regulation of mitotic cell cycle [GO:0007346]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12917326}. Cytoplasm {ECO:0000269|PubMed:12917326}. Melanosome {ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:17081065}.
P62263	reviewed	RS14_HUMAN	Small ribosomal subunit protein uS11 (40S ribosomal protein S14)	RPS14 PRO2640	Homo sapiens (Human)	151	FUNCTION: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; erythrocyte differentiation [GO:0030218]; maturation of SSU-rRNA [GO:0030490]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; small-subunit processome [GO:0032040]	mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; small-subunit processome [GO:0032040]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182]; cytoplasmic translation [GO:0002181]; erythrocyte differentiation [GO:0030218]; maturation of SSU-rRNA [GO:0030490]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
P62266	reviewed	RS23_HUMAN	Small ribosomal subunit protein uS12 (40S ribosomal protein S23)	RPS23	Homo sapiens (Human)	143	FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28257692, PubMed:23636399, PubMed:25957688, PubMed:25901680). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399, PubMed:25957688, PubMed:25901680). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399, PubMed:25957688, PubMed:25901680). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25957688, PubMed:25901680). Plays an important role in translational accuracy (PubMed:28257692). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:28257692, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; maintenance of translational fidelity [GO:1990145]; ribosomal small subunit biogenesis [GO:0042274]; stress granule assembly [GO:0034063]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; ribosome [GO:0005840]; rough endoplasmic reticulum [GO:0005791]; small-subunit processome [GO:0032040]; synapse [GO:0045202]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; ribosome [GO:0005840]; rough endoplasmic reticulum [GO:0005791]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; maintenance of translational fidelity [GO:1990145]; ribosomal small subunit biogenesis [GO:0042274]; stress granule assembly [GO:0034063]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q6SA96}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q6SA96, ECO:0000269|PubMed:25957688}.
P62269	reviewed	RS18_HUMAN	Small ribosomal subunit protein uS13 (40S ribosomal protein S18) (Ke-3) (Ke3)	RPS18 D6S218E	Homo sapiens (Human)	152	FUNCTION: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P62273	reviewed	RS29_HUMAN	Small ribosomal subunit protein uS14 (40S ribosomal protein S29)	RPS29	Homo sapiens (Human)	56	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; small ribosomal subunit [GO:0015935]	structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; small ribosomal subunit [GO:0015935]; structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q6QAP6}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q6QAP6, ECO:0000269|PubMed:25957688}.
P62277	reviewed	RS13_HUMAN	Small ribosomal subunit protein uS15 (40S ribosomal protein S13)	RPS13	Homo sapiens (Human)	151	FUNCTION: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; negative regulation of RNA splicing [GO:0033119]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]	mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; negative regulation of RNA splicing [GO:0033119]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
P62280	reviewed	RS11_HUMAN	Small ribosomal subunit protein uS17 (40S ribosomal protein S11)	RPS11	Homo sapiens (Human)	158	FUNCTION: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
P62304	reviewed	RUXE_HUMAN	Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE)	SNRPE	Homo sapiens (Human)	92	FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:23246290, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12975319, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23246290, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}.	MISCELLANEOUS: Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins.	7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683]; RNA binding [GO:0003723]; 7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:23246290, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
P62306	reviewed	RUXF_HUMAN	Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF)	SNRPF PBSCF	Homo sapiens (Human)	86	FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12975319, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}.		7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683]; RNA binding [GO:0003723]; 7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
P62308	reviewed	RUXG_HUMAN	Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG)	SNRPG PBSCG	Homo sapiens (Human)	76	FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12975319, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}.		7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; spliceosomal tri-snRNP complex [GO:0097526]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; spliceosomal tri-snRNP complex [GO:0097526]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683]; RNA binding [GO:0003723]; 7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
P62310	reviewed	LSM3_HUMAN	U6 snRNA-associated Sm-like protein LSm3	LSM3 MDS017	Homo sapiens (Human)	102	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.		mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; P-body assembly [GO:0033962]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]	RNA binding [GO:0003723]; U6 snRNA 3'-end binding [GO:0030629]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]; RNA binding [GO:0003723]; U6 snRNA 3'-end binding [GO:0030629]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; P-body assembly [GO:0033962]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
P62312	reviewed	LSM6_HUMAN	U6 snRNA-associated Sm-like protein LSm6	LSM6	Homo sapiens (Human)	80	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway (Probable). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166, ECO:0000305|PubMed:12515382}.		maturation of SSU-rRNA [GO:0030490]; mRNA catabolic process [GO:0006402]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; tRNA processing [GO:0008033]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lsm2-8 complex [GO:0120115]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; small nuclear ribonucleoprotein complex [GO:0030532]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]	protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lsm2-8 complex [GO:0120115]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; small nuclear ribonucleoprotein complex [GO:0030532]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; maturation of SSU-rRNA [GO:0030490]; mRNA catabolic process [GO:0006402]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; tRNA processing [GO:0008033]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12515382}. Nucleus {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
P62314	reviewed	SMD1_HUMAN	Small nuclear ribonucleoprotein Sm D1 (Sm-D1) (Sm-D autoantigen) (snRNP core protein D1)	SNRPD1	Homo sapiens (Human)	119	FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (Probable). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000305|PubMed:23333303}.	MISCELLANEOUS: In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.	7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; commitment complex [GO:0000243]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; spliceosomal tri-snRNP complex [GO:0097526]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; commitment complex [GO:0000243]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; spliceosomal tri-snRNP complex [GO:0097526]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; RNA binding [GO:0003723]; 7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:21113136, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
P62316	reviewed	SMD2_HUMAN	Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2)	SNRPD2 SNRPD1	Homo sapiens (Human)	118	FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}.	MISCELLANEOUS: In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.	7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]	RNA binding [GO:0003723]; U1 snRNP binding [GO:1990446]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; RNA binding [GO:0003723]; U1 snRNP binding [GO:1990446]; 7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
P62318	reviewed	SMD3_HUMAN	Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)	SNRPD3	Homo sapiens (Human)	126	FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). {ECO:0000250|UniProtKB:P62320, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}.	MISCELLANEOUS: In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.	7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; protein methylation [GO:0006479]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; commitment complex [GO:0000243]; cytosol [GO:0005829]; methylosome [GO:0034709]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; spliceosomal tri-snRNP complex [GO:0097526]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683]	enzyme binding [GO:0019899]; histone pre-mRNA DCP binding [GO:0071208]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; U7 snRNA binding [GO:0071209]	catalytic step 2 spliceosome [GO:0071013]; commitment complex [GO:0000243]; cytosol [GO:0005829]; methylosome [GO:0034709]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; spliceosomal tri-snRNP complex [GO:0097526]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683]; enzyme binding [GO:0019899]; histone pre-mRNA DCP binding [GO:0071208]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; U7 snRNA binding [GO:0071209]; 7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; protein methylation [GO:0006479]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
P62324	reviewed	BTG1_HUMAN	Protein BTG1 (B-cell translocation gene 1 protein)	BTG1	Homo sapiens (Human)	171	FUNCTION: Anti-proliferative protein. {ECO:0000269|PubMed:1373383}.		cell migration [GO:0016477]; cell population proliferation [GO:0008283]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of myoblast differentiation [GO:0045663]; regulation of DNA-templated transcription [GO:0006355]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	enzyme binding [GO:0019899]; kinase binding [GO:0019900]; transcription coregulator activity [GO:0003712]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; kinase binding [GO:0019900]; transcription coregulator activity [GO:0003712]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of myoblast differentiation [GO:0045663]; regulation of DNA-templated transcription [GO:0006355]	
P62328	reviewed	TYB4_HUMAN	Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hemoregulatory peptide AcSDKP (Ac-Ser-Asp-Lys-Pro) (N-acetyl-SDKP) (AcSDKP) (Seraspenide)]	TMSB4X TB4X THYB4 TMSB4	Homo sapiens (Human)	44	FUNCTION: Plays an important role in the organization of the cytoskeleton (PubMed:1999398, PubMed:10848969). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:1999398, PubMed:10848969). {ECO:0000269|PubMed:10848969, ECO:0000269|PubMed:1999398}.; FUNCTION: [Hemoregulatory peptide AcSDKP]: Potent inhibitor of bone marrow derived stem cell differentiation (PubMed:7694679). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity). {ECO:0000250|UniProtKB:P62326, ECO:0000269|PubMed:7694679}.		actin filament organization [GO:0007015]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of proton-transporting ATP synthase activity, rotational mechanism [GO:1905273]; regulation of cell migration [GO:0030334]; regulation of inflammatory response [GO:0050727]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; sequestering of actin monomers [GO:0042989]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]	actin monomer binding [GO:0003785]; enzyme binding [GO:0019899]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; actin monomer binding [GO:0003785]; enzyme binding [GO:0019899]; RNA binding [GO:0003723]; actin filament organization [GO:0007015]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of proton-transporting ATP synthase activity, rotational mechanism [GO:1905273]; regulation of cell migration [GO:0030334]; regulation of inflammatory response [GO:0050727]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; sequestering of actin monomers [GO:0042989]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:1999398}.
P62330	reviewed	ARF6_HUMAN	ADP-ribosylation factor 6 (EC 3.6.5.2)	ARF6	Homo sapiens (Human)	175	FUNCTION: GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:21170023, PubMed:16737952, PubMed:7589240, PubMed:18400762, PubMed:32103017). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (By similarity). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity). {ECO:0000250|UniProtKB:P62331, ECO:0000250|UniProtKB:P62332, ECO:0000269|PubMed:11266366, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:16099990, ECO:0000269|PubMed:16737952, ECO:0000269|PubMed:18400762, ECO:0000269|PubMed:21170023, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}.; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000269|PubMed:16099990}.		cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cell division [GO:0051301]; cellular response to nerve growth factor stimulus [GO:1990090]; cortical actin cytoskeleton organization [GO:0030866]; endocytic recycling [GO:0032456]; erythrocyte apoptotic process [GO:1902217]; establishment of epithelial cell polarity [GO:0090162]; hepatocyte apoptotic process [GO:0097284]; intracellular protein transport [GO:0006886]; liver development [GO:0001889]; maintenance of postsynaptic density structure [GO:0099562]; negative regulation of dendrite development [GO:2000171]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of receptor-mediated endocytosis [GO:0048261]; nervous system development [GO:0007399]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein secretion [GO:0050714]; protein localization to cell surface [GO:0034394]; protein localization to endosome [GO:0036010]; regulation of dendritic spine development [GO:0060998]; regulation of filopodium assembly [GO:0051489]; regulation of presynapse assembly [GO:1905606]; regulation of Rac protein signal transduction [GO:0035020]; ruffle assembly [GO:0097178]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192]	cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; recycling endosome membrane [GO:0055038]; ruffle [GO:0001726]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; thioesterase binding [GO:0031996]	cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; recycling endosome membrane [GO:0055038]; ruffle [GO:0001726]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; thioesterase binding [GO:0031996]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cell division [GO:0051301]; cellular response to nerve growth factor stimulus [GO:1990090]; cortical actin cytoskeleton organization [GO:0030866]; endocytic recycling [GO:0032456]; erythrocyte apoptotic process [GO:1902217]; establishment of epithelial cell polarity [GO:0090162]; hepatocyte apoptotic process [GO:0097284]; intracellular protein transport [GO:0006886]; liver development [GO:0001889]; maintenance of postsynaptic density structure [GO:0099562]; negative regulation of dendrite development [GO:2000171]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of receptor-mediated endocytosis [GO:0048261]; nervous system development [GO:0007399]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein secretion [GO:0050714]; protein localization to cell surface [GO:0034394]; protein localization to endosome [GO:0036010]; regulation of dendritic spine development [GO:0060998]; regulation of filopodium assembly [GO:0051489]; regulation of presynapse assembly [GO:1905606]; regulation of Rac protein signal transduction [GO:0035020]; ruffle assembly [GO:0097178]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16737952, ECO:0000269|PubMed:23603394, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}. Cell membrane {ECO:0000269|PubMed:16737952, ECO:0000269|PubMed:17398095, ECO:0000269|PubMed:17555535, ECO:0000269|PubMed:32103017}; Lipid-anchor {ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}. Endosome membrane {ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20682791, ECO:0000269|PubMed:21951725}; Lipid-anchor {ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}. Recycling endosome membrane {ECO:0000269|PubMed:21951725}; Lipid-anchor {ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}. Cell projection, filopodium membrane {ECO:0000269|PubMed:14978216}; Lipid-anchor {ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}. Cell projection, ruffle {ECO:0000269|PubMed:16737952}. Cleavage furrow {ECO:0000269|PubMed:23603394}. Midbody, Midbody ring {ECO:0000269|PubMed:23603394}. Early endosome membrane {ECO:0000250|UniProtKB:P62331}; Lipid-anchor {ECO:0000250|UniProtKB:P62331}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P62331}; Lipid-anchor {ECO:0000250|UniProtKB:P62331}. Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In late stages of cytokinesis, concentrates at the midbody ring/Flemming body (PubMed:23603394). Recruitment to the midbody ring requires both activation by PSD/EFA6A and interaction with KIF23/MKLP1 (PubMed:23603394). After abscission of the intercellular bridge, incorporated into one of the daughter cells as a midbody remnant and localizes to punctate structures beneath the plasma membrane (PubMed:23603394). Recruited to the cell membrane in association with CYTH2 and ARL4C (PubMed:17398095). Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles (PubMed:19948740). Myristoylation is required for proper localization to membranes: myristoylation on Lys-3 allows ARF6 to remain on membranes during the GTPase cycle (PubMed:7589240, PubMed:32103017). {ECO:0000269|PubMed:17398095, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:23603394, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}.
P62333	reviewed	PRS10_HUMAN	26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)	PSMC6 SUG2	Homo sapiens (Human)	389	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.		positive regulation of inclusion body assembly [GO:0090261]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular exosome [GO:0070062]; inclusion body [GO:0016234]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; proteasome-activating activity [GO:0036402]; protein-macromolecule adaptor activity [GO:0030674]	cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular exosome [GO:0070062]; inclusion body [GO:0016234]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; proteasome-activating activity [GO:0036402]; protein-macromolecule adaptor activity [GO:0030674]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
P62341	reviewed	SELT_HUMAN	Thioredoxin reductase-like selenoprotein T (SelT) (EC 1.8.1.9)	SELENOT SELT UNQ150/PRO176	Homo sapiens (Human)	195	FUNCTION: Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity). {ECO:0000250|UniProtKB:P62342, ECO:0000250|UniProtKB:Q1H5H1, ECO:0000269|PubMed:26866473}.		cell redox homeostasis [GO:0045454]; cellular oxidant detoxification [GO:0098869]; glucose homeostasis [GO:0042593]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; pancreas development [GO:0031016]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of growth hormone secretion [GO:0060124]; response to glucose [GO:0009749]; selenocysteine incorporation [GO:0001514]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	selenium binding [GO:0008430]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; selenium binding [GO:0008430]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]; cell redox homeostasis [GO:0045454]; cellular oxidant detoxification [GO:0098869]; glucose homeostasis [GO:0042593]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; pancreas development [GO:0031016]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of growth hormone secretion [GO:0060124]; response to glucose [GO:0009749]; selenocysteine incorporation [GO:0001514]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1H5H1}; Single-pass membrane protein {ECO:0000255}.
P62380	reviewed	TBPL1_HUMAN	TATA box-binding protein-like 1 (TBP-like 1) (21 kDa TBP-like protein) (Second TBP of unique DNA protein) (STUD) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (TBP-related protein)	TBPL1 TLF TLP TLP21 TRF2 TRP	Homo sapiens (Human)	186	FUNCTION: Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. {ECO:0000269|PubMed:10082669, ECO:0000269|PubMed:10220372, ECO:0000269|PubMed:15767669, ECO:0000269|PubMed:24958592}.		acrosome assembly [GO:0001675]; DNA-templated transcription initiation [GO:0006352]; dTTP biosynthetic process [GO:0006235]; spermatid nucleus differentiation [GO:0007289]; transcription by RNA polymerase II [GO:0006366]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; transcription factor TFIIA complex [GO:0005672]	general transcription initiation factor activity [GO:0140223]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; transcription factor TFIIA complex [GO:0005672]; general transcription initiation factor activity [GO:0140223]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; acrosome assembly [GO:0001675]; DNA-templated transcription initiation [GO:0006352]; dTTP biosynthetic process [GO:0006235]; spermatid nucleus differentiation [GO:0007289]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
P62424	reviewed	RL7A_HUMAN	Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) (PLA-X polypeptide) (Surfeit locus protein 3)	RPL7A SURF-3 SURF3	Homo sapiens (Human)	266	FUNCTION: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; synapse [GO:0045202]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; synapse [GO:0045202]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P62487	reviewed	RPB7_HUMAN	DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19)	POLR2G RPB7	Homo sapiens (Human)	172	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RPB4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA. {ECO:0000250, ECO:0000269|PubMed:9852112}.		nuclear-transcribed mRNA catabolic process, exonucleolytic [GO:0000291]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of translational initiation [GO:0045948]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; RNA polymerase II, core complex [GO:0005665]	single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; translation initiation factor binding [GO:0031369]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; RNA polymerase II, core complex [GO:0005665]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; translation initiation factor binding [GO:0031369]; nuclear-transcribed mRNA catabolic process, exonucleolytic [GO:0000291]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of translational initiation [GO:0045948]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
P62491	reviewed	RB11A_HUMAN	Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8)	RAB11A RAB11	Homo sapiens (Human)	216	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling (PubMed:20026645). Forms a functional Rab11/FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:15601896). Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes. Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879, PubMed:31204173). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (PubMed:32344433). {ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:17462998, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}.		amyloid-beta clearance by transcytosis [GO:0150093]; astral microtubule organization [GO:0030953]; establishment of protein localization to membrane [GO:0090150]; establishment of protein localization to organelle [GO:0072594]; establishment of vesicle localization [GO:0051650]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; multivesicular body assembly [GO:0036258]; neuron projection development [GO:0031175]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; plasma membrane to endosome transport [GO:0048227]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein localization to cell surface [GO:0034394]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]; regulation of cilium assembly [GO:1902017]; regulation of cytokinesis [GO:0032465]; regulation of early endosome to recycling endosome transport [GO:1902954]; regulation of endocytic recycling [GO:2001135]; regulation of multivesicular body size [GO:0010796]; regulation of protein localization to centrosome [GO:1904779]; regulation of vesicle-mediated transport [GO:0060627]; vesicle-mediated transport [GO:0016192]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; multivesicular body [GO:0005771]; phagocytic vesicle [GO:0045335]; postsynaptic recycling endosome [GO:0098837]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; spindle pole [GO:0000922]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; vesicle [GO:0031982]	dynein light intermediate chain binding [GO:0051959]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; myosin V binding [GO:0031489]; syntaxin binding [GO:0019905]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; multivesicular body [GO:0005771]; phagocytic vesicle [GO:0045335]; postsynaptic recycling endosome [GO:0098837]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; spindle pole [GO:0000922]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; vesicle [GO:0031982]; dynein light intermediate chain binding [GO:0051959]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; myosin V binding [GO:0031489]; syntaxin binding [GO:0019905]; amyloid-beta clearance by transcytosis [GO:0150093]; astral microtubule organization [GO:0030953]; establishment of protein localization to membrane [GO:0090150]; establishment of protein localization to organelle [GO:0072594]; establishment of vesicle localization [GO:0051650]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; multivesicular body assembly [GO:0036258]; neuron projection development [GO:0031175]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; plasma membrane to endosome transport [GO:0048227]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein localization to cell surface [GO:0034394]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]; regulation of cilium assembly [GO:1902017]; regulation of cytokinesis [GO:0032465]; regulation of early endosome to recycling endosome transport [GO:1902954]; regulation of endocytic recycling [GO:2001135]; regulation of multivesicular body size [GO:0010796]; regulation of protein localization to centrosome [GO:1904779]; regulation of vesicle-mediated transport [GO:0060627]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15304524}; Lipid-anchor {ECO:0000305|PubMed:24023390}. Endosome membrane {ECO:0000269|PubMed:32344433}. Recycling endosome membrane {ECO:0000269|PubMed:11994279, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:29514919}; Lipid-anchor {ECO:0000305|PubMed:24023390}. Cleavage furrow {ECO:0000269|PubMed:15601896}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:30217979}. Golgi apparatus {ECO:0000269|PubMed:25673879}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:25673879}. Note=Localized to WDR44-positive endosomes and tubules (PubMed:32344433). Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279). During interphase, localized in vesicles continuously moving from peripheral sorting endosomes towards the pericentrosomal ERC (PubMed:20026645). Localizes to the cleavage furrow (PubMed:15601896). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). Localized to rhodopsin transport carriers when interacting with RAB11AFIP3 and ASAP1 in photoreceptors (PubMed:25673879). {ECO:0000269|PubMed:11994279, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:32344433}.
P62495	reviewed	ERF1_HUMAN	Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)	ETF1 ERF1 RF1 SUP45L1	Homo sapiens (Human)	437	FUNCTION: Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:7990965, PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793). The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:26245381, PubMed:27863242, PubMed:36638793). ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA (PubMed:26245381, PubMed:27863242, PubMed:36638793). Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA (PubMed:10676813, PubMed:16777602, PubMed:26245381, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:10676813, ECO:0000269|PubMed:16777602, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:26245381, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:30682371, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:7990965}.		cytoplasmic translational termination [GO:0002184]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]; regulation of translational termination [GO:0006449]; translational termination [GO:0006415]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; translation release factor complex [GO:0018444]	aminoacyl-tRNA hydrolase activity [GO:0004045]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]; translation termination factor activity [GO:0008079]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; translation release factor complex [GO:0018444]; aminoacyl-tRNA hydrolase activity [GO:0004045]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]; translation termination factor activity [GO:0008079]; cytoplasmic translational termination [GO:0002184]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]; regulation of translational termination [GO:0006449]; translational termination [GO:0006415]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24486019}.
P62508	reviewed	ERR3_HUMAN	Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)	ESRRG ERR3 ERRG2 KIAA0832 NR3B3	Homo sapiens (Human)	458	FUNCTION: Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle. {ECO:0000250, ECO:0000269|PubMed:11864604, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:19067653, ECO:0000269|PubMed:23836911}.	MISCELLANEOUS: No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.	intracellular steroid hormone receptor signaling pathway [GO:0030518]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retinoic acid receptor signaling pathway [GO:0048384]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	AF-2 domain binding [GO:0050682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; identical protein binding [GO:0042802]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; AF-2 domain binding [GO:0050682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; identical protein binding [GO:0042802]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retinoic acid receptor signaling pathway [GO:0048384]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P62633	reviewed	CNBP_HUMAN	CCHC-type zinc finger nucleic acid binding protein (Cellular nucleic acid-binding protein) (CNBP) (Zinc finger protein 9)	CNBP RNF163 ZNF9	Homo sapiens (Human)	177	FUNCTION: Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (PubMed:2562787). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity). {ECO:0000250|UniProtKB:P53996, ECO:0000250|UniProtKB:P62634, ECO:0000269|PubMed:2562787}.; FUNCTION: [Isoform 1]: Binds G-rich elements in target mRNA coding sequences (PubMed:28329689). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (PubMed:28329689). {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 2]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 4]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 5]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 6]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 8]: Binds to RNA. {ECO:0000269|PubMed:28329689}.		cholesterol homeostasis [GO:0042632]; G-quadruplex DNA formation [GO:0071919]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]	G-quadruplex DNA binding [GO:0051880]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; translation regulator activity [GO:0045182]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; G-quadruplex DNA binding [GO:0051880]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; translation regulator activity [GO:0045182]; zinc ion binding [GO:0008270]; cholesterol homeostasis [GO:0042632]; G-quadruplex DNA formation [GO:0071919]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53996}. Cytoplasm {ECO:0000269|PubMed:28329689}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P53996}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:28329689}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:28329689}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:28329689}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:28329689}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000269|PubMed:28329689}.; SUBCELLULAR LOCATION: [Isoform 8]: Cytoplasm {ECO:0000269|PubMed:28329689}.
P62699	reviewed	YPEL5_HUMAN	Protein yippee-like 5	YPEL5 CGI-127	Homo sapiens (Human)	121	FUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for normal cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q65Z55, ECO:0000269|PubMed:29911972}.		cell population proliferation [GO:0008283]	extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]; ubiquitin ligase complex [GO:0000151]	metal ion binding [GO:0046872]	extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]; ubiquitin ligase complex [GO:0000151]; metal ion binding [GO:0046872]; cell population proliferation [GO:0008283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q65Z55}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q65Z55}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q65Z55}. Midbody {ECO:0000250|UniProtKB:Q65Z55}. Note=Deteted in nucleus and at the centrosome during interphase. During mitosis, detected on the mitotic spindle, at spindle poles and at the midbody. {ECO:0000250|UniProtKB:Q65Z55}.
P62701	reviewed	RS4X_HUMAN	Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein)	RPS4X CCG2 RPS4 SCAR	Homo sapiens (Human)	263	FUNCTION: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of translation [GO:0045727]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of translation [GO:0045727]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:17289661}.
P62714	reviewed	PP2AB_HUMAN	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16)	PPP2CB	Homo sapiens (Human)	309	FUNCTION: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. {ECO:0000269|PubMed:2555176, ECO:0000305}.		apoptotic mitochondrial changes [GO:0008637]; mitotic cell cycle [GO:0000278]; negative regulation of gene expression [GO:0010629]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of microtubule binding [GO:1904528]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; response to antibiotic [GO:0046677]; response to endoplasmic reticulum stress [GO:0034976]; response to hydrogen peroxide [GO:0042542]; response to lead ion [GO:0010288]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]; spindle pole [GO:0000922]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; tau protein binding [GO:0048156]; transmembrane transporter binding [GO:0044325]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]; spindle pole [GO:0000922]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; tau protein binding [GO:0048156]; transmembrane transporter binding [GO:0044325]; apoptotic mitochondrial changes [GO:0008637]; mitotic cell cycle [GO:0000278]; negative regulation of gene expression [GO:0010629]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of microtubule binding [GO:1904528]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; response to antibiotic [GO:0046677]; response to endoplasmic reticulum stress [GO:0034976]; response to hydrogen peroxide [GO:0042542]; response to lead ion [GO:0010288]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16541025}. Nucleus {ECO:0000269|PubMed:16541025}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
P62736	reviewed	ACTA_HUMAN	Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]	ACTA2 ACTSA ACTVS GIG46	Homo sapiens (Human)	377	FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	MISCELLANEOUS: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.	cellular response to transforming growth factor beta stimulus [GO:0071560]; glomerular mesangial cell development [GO:0072144]; juxtaglomerular apparatus development [GO:0072051]; mesenchyme migration [GO:0090131]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell contraction [GO:0061874]; positive regulation of hepatic stellate cell migration [GO:0061870]; regulation of blood pressure [GO:0008217]; response to virus [GO:0009615]; vascular associated smooth muscle contraction [GO:0014829]	basement membrane [GO:0005604]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; motile cilium [GO:0031514]; protein-containing complex [GO:0032991]; smooth muscle contractile fiber [GO:0030485]; stress fiber [GO:0001725]	ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; protein kinase binding [GO:0019901]	basement membrane [GO:0005604]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; motile cilium [GO:0031514]; protein-containing complex [GO:0032991]; smooth muscle contractile fiber [GO:0030485]; stress fiber [GO:0001725]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; protein kinase binding [GO:0019901]; cellular response to transforming growth factor beta stimulus [GO:0071560]; glomerular mesangial cell development [GO:0072144]; juxtaglomerular apparatus development [GO:0072051]; mesenchyme migration [GO:0090131]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell contraction [GO:0061874]; positive regulation of hepatic stellate cell migration [GO:0061870]; regulation of blood pressure [GO:0008217]; response to virus [GO:0009615]; vascular associated smooth muscle contraction [GO:0014829]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P62745	reviewed	RHOB_HUMAN	Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)	RHOB ARH6 ARHB	Homo sapiens (Human)	196	FUNCTION: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. {ECO:0000269|PubMed:10508588, ECO:0000269|PubMed:15226397, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:9478917}.	MISCELLANEOUS: RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects.	actin filament organization [GO:0007015]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to ionizing radiation [GO:0071479]; endosome to lysosome transport [GO:0008333]; endothelial tube morphogenesis [GO:0061154]; intracellular protein transport [GO:0006886]; mitotic cytokinesis [GO:0000281]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell migration [GO:0010595]; regulation of cell migration [GO:0030334]; regulation of modification of postsynaptic structure [GO:0099159]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]	cleavage furrow [GO:0032154]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; late endosome membrane [GO:0031902]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cleavage furrow [GO:0032154]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; late endosome membrane [GO:0031902]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; actin filament organization [GO:0007015]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to ionizing radiation [GO:0071479]; endosome to lysosome transport [GO:0008333]; endothelial tube morphogenesis [GO:0061154]; intracellular protein transport [GO:0006886]; mitotic cytokinesis [GO:0000281]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell migration [GO:0010595]; regulation of cell migration [GO:0030334]; regulation of modification of postsynaptic structure [GO:0099159]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
P62750	reviewed	RL23A_HUMAN	Large ribosomal subunit protein uL23 (60S ribosomal protein L23a)	RPL23A	Homo sapiens (Human)	156	FUNCTION: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Binds a specific region on the 26S rRNA (PubMed:23636399, PubMed:32669547). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; TORC2 complex binding [GO:1904841]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; TORC2 complex binding [GO:1904841]; cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:9687515}. Nucleus {ECO:0000269|PubMed:9687515}. Note=Although RPL23A is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL23A nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9687515}.
P62753	reviewed	RS6_HUMAN	Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33)	RPS6 OK/SW-cl.2	Homo sapiens (Human)	249	FUNCTION: Component of the 40S small ribosomal subunit (PubMed:8706699, PubMed:23636399). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}.		activation-induced cell death of T cells [GO:0006924]; cytoplasmic translation [GO:0002181]; erythrocyte development [GO:0048821]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; glucose homeostasis [GO:0042593]; mammalian oogenesis stage [GO:0022605]; negative regulation of apoptotic process [GO:0043066]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; T cell differentiation in thymus [GO:0033077]; T cell proliferation involved in immune response [GO:0002309]; TOR signaling [GO:0031929]; translation [GO:0006412]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]	protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; activation-induced cell death of T cells [GO:0006924]; cytoplasmic translation [GO:0002181]; erythrocyte development [GO:0048821]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; glucose homeostasis [GO:0042593]; mammalian oogenesis stage [GO:0022605]; negative regulation of apoptotic process [GO:0043066]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; T cell differentiation in thymus [GO:0033077]; T cell proliferation involved in immune response [GO:0002309]; TOR signaling [GO:0031929]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
P62760	reviewed	VISL1_HUMAN	Visinin-like protein 1 (VILIP) (VLP-1) (Hippocalcin-like protein 3) (HLP3)	VSNL1 VISL1	Homo sapiens (Human)	191	FUNCTION: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. {ECO:0000250}.	MISCELLANEOUS: Probably binds three calcium ions.	negative regulation of insulin secretion [GO:0046676]; positive regulation of exocytosis [GO:0045921]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	cytosol [GO:0005829]; membrane [GO:0016020]	calcium ion binding [GO:0005509]	cytosol [GO:0005829]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; negative regulation of insulin secretion [GO:0046676]; positive regulation of exocytosis [GO:0045921]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	
P62805	reviewed	H4_HUMAN	Histone H4	H4C1 H4/A H4FA HIST1H4A; H4C2 H4/I H4FI HIST1H4B; H4C3 H4/G H4FG HIST1H4C; H4C4 H4/B H4FB HIST1H4D; H4C5 H4/J H4FJ HIST1H4E; H4C6 H4/C H4FC HIST1H4F; H4C8 H4/H H4FH HIST1H4H; H4C9 H4/M H4FM HIST1H4I; H4C11 H4/E H4FE HIST1H4J; H4C12 H4/D H4FD HIST1H4K; H4C13 H4/K H4FK HIST1H4L; H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A; H4C15 H4/O H4FO HIST2H4B; H4C16 H4-16 HIST4H4	Homo sapiens (Human)	103	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		chromatin organization [GO:0006325]; negative regulation of megakaryocyte differentiation [GO:0045653]; nucleosome assembly [GO:0006334]; protein localization to CENP-A containing chromatin [GO:0061644]; telomere organization [GO:0032200]	CENP-A containing nucleosome [GO:0043505]; chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]	CENP-A containing nucleosome [GO:0043505]; chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]; chromatin organization [GO:0006325]; negative regulation of megakaryocyte differentiation [GO:0045653]; nucleosome assembly [GO:0006334]; protein localization to CENP-A containing chromatin [GO:0061644]; telomere organization [GO:0032200]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P62807	reviewed	H2B1C_HUMAN	Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; nucleosome assembly [GO:0006334]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P62820	reviewed	RAB1A_HUMAN	Ras-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein)	RAB1A RAB1	Homo sapiens (Human)	205	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Regulates the level of CASR present at the cell membrane (PubMed:20861236). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (PubMed:22939626). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity). {ECO:0000250|UniProtKB:P62821, ECO:0000269|PubMed:20639577, ECO:0000269|PubMed:20861236, ECO:0000269|PubMed:21303926, ECO:0000269|PubMed:22939626, ECO:0000269|PubMed:26209634}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cell migration [GO:0016477]; COPII-coated vesicle cargo loading [GO:0090110]; defense response to bacterium [GO:0042742]; endocytosis [GO:0006897]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; growth hormone secretion [GO:0030252]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; positive regulation of glycoprotein metabolic process [GO:1903020]; positive regulation of interleukin-8 production [GO:0032757]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle transport along microtubule [GO:0047496]; vesicle-mediated transport [GO:0016192]; virion assembly [GO:0019068]	cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; melanosome [GO:0042470]; transport vesicle membrane [GO:0030658]	cadherin binding [GO:0045296]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; melanosome [GO:0042470]; transport vesicle membrane [GO:0030658]; cadherin binding [GO:0045296]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cell migration [GO:0016477]; COPII-coated vesicle cargo loading [GO:0090110]; defense response to bacterium [GO:0042742]; endocytosis [GO:0006897]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; growth hormone secretion [GO:0030252]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; positive regulation of glycoprotein metabolic process [GO:1903020]; positive regulation of interleukin-8 production [GO:0032757]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle transport along microtubule [GO:0047496]; vesicle-mediated transport [GO:0016192]; virion assembly [GO:0019068]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:22939626}. Endoplasmic reticulum {ECO:0000269|PubMed:22939626}. Early endosome {ECO:0000269|PubMed:21303926}. Cytoplasm, cytosol {ECO:0000305|PubMed:19942850}. Membrane {ECO:0000269|PubMed:19942850, ECO:0000269|PubMed:23815289}. Melanosome {ECO:0000250|UniProtKB:P62821}. Note=Alternates between membrane-associated and cytosolic forms. {ECO:0000305|PubMed:19942850}.
P62826	reviewed	RAN_HUMAN	GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)	RAN ARA24 OK/SW-cl.81	Homo sapiens (Human)	216	FUNCTION: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:8276887, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:17209048, PubMed:26272610, PubMed:27306458). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:7819259, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:29040603, PubMed:11336674, PubMed:26272610). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:8421051, PubMed:12194828, PubMed:29040603). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640). {ECO:0000269|PubMed:10400640, ECO:0000269|PubMed:10408446, ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17209048, ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:26272610, ECO:0000269|PubMed:27306458, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:7819259, ECO:0000269|PubMed:8276887, ECO:0000269|PubMed:8421051, ECO:0000269|PubMed:8636225, ECO:0000269|PubMed:8692944, ECO:0000269|PubMed:8896452, ECO:0000269|PubMed:9351834, ECO:0000269|PubMed:9428644, ECO:0000269|PubMed:9822603, ECO:0000305|PubMed:26272610}.		actin cytoskeleton organization [GO:0030036]; cell division [GO:0051301]; cellular response to mineralocorticoid stimulus [GO:0071389]; DNA metabolic process [GO:0006259]; GTP metabolic process [GO:0046039]; hippocampus development [GO:0021766]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus [GO:0042307]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein localization to nucleolus [GO:1902570]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; ribosomal subunit export from nucleus [GO:0000054]; snRNA import into nucleus [GO:0061015]; spermatid development [GO:0007286]; viral process [GO:0016032]	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; manchette [GO:0002177]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; RNA nuclear export complex [GO:0042565]; sperm flagellum [GO:0036126]	cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; dynein intermediate chain binding [GO:0045505]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; importin-alpha family protein binding [GO:0061676]; magnesium ion binding [GO:0000287]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; manchette [GO:0002177]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; RNA nuclear export complex [GO:0042565]; sperm flagellum [GO:0036126]; cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; dynein intermediate chain binding [GO:0045505]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; importin-alpha family protein binding [GO:0061676]; magnesium ion binding [GO:0000287]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; actin cytoskeleton organization [GO:0030036]; cell division [GO:0051301]; cellular response to mineralocorticoid stimulus [GO:0071389]; DNA metabolic process [GO:0006259]; GTP metabolic process [GO:0046039]; hippocampus development [GO:0021766]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus [GO:0042307]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein localization to nucleolus [GO:1902570]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; ribosomal subunit export from nucleus [GO:0000054]; snRNA import into nucleus [GO:0061015]; spermatid development [GO:0007286]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:1961752, ECO:0000269|PubMed:19753112, ECO:0000269|PubMed:31075303, ECO:0000269|PubMed:8421051, ECO:0000269|PubMed:8896452, ECO:0000269|PubMed:9351834, ECO:0000269|PubMed:9822603}. Nucleus envelope {ECO:0000269|PubMed:8896452, ECO:0000269|PubMed:9822603}. Cytoplasm, cytosol {ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:8276887}. Cytoplasm {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:9822603}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Predominantly nuclear during interphase (PubMed:8421051, PubMed:12194828, PubMed:10679025). Becomes dispersed throughout the cytoplasm during mitosis (PubMed:8421051, PubMed:12194828). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:8421051}.
P62829	reviewed	RL23_HUMAN	Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23)	RPL23	Homo sapiens (Human)	140	FUNCTION: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cellular response to actinomycin D [GO:0072717]; cytoplasmic translation [GO:0002181]; G1 to G0 transition [GO:0070314]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; protein stabilization [GO:0050821]; protein-DNA complex disassembly [GO:0032986]; regulation of G1 to G0 transition [GO:1903450]; ribosomal protein import into nucleus [GO:0006610]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ribosome [GO:0005840]; synapse [GO:0045202]	large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; transcription coactivator binding [GO:0001223]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ribosome [GO:0005840]; synapse [GO:0045202]; large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; transcription coactivator binding [GO:0001223]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625]; cellular response to actinomycin D [GO:0072717]; cytoplasmic translation [GO:0002181]; G1 to G0 transition [GO:0070314]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; protein stabilization [GO:0050821]; protein-DNA complex disassembly [GO:0032986]; regulation of G1 to G0 transition [GO:1903450]; ribosomal protein import into nucleus [GO:0006610]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P62834	reviewed	RAP1A_HUMAN	Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)	RAP1A KREV1	Homo sapiens (Human)	184	FUNCTION: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392}.		cellular response to cAMP [GO:0071320]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; synaptic vesicle exocytosis [GO:0016079]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; guanyl-nucleotide exchange factor complex [GO:0032045]; late endosome [GO:0005770]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; specific granule membrane [GO:0035579]; sperm midpiece [GO:0097225]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; guanyl-nucleotide exchange factor complex [GO:0032045]; late endosome [GO:0005770]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; specific granule membrane [GO:0035579]; sperm midpiece [GO:0097225]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]; cellular response to cAMP [GO:0071320]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; synaptic vesicle exocytosis [GO:0016079]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11359771}; Lipid-anchor {ECO:0000269|PubMed:11359771}. Cytoplasm {ECO:0000269|PubMed:11359771}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11359771}. Cell junction {ECO:0000250}. Early endosome {ECO:0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.
P62837	reviewed	UB2D2_HUMAN	Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)	UBE2D2 PUBC1 UBC4 UBC5B UBCH4 UBCH5B	Homo sapiens (Human)	147	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:26475854, PubMed:10329681, PubMed:18042044, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694). Catalyzes 'Lys-48'-linked polyubiquitination (PubMed:26475854, PubMed:10329681, PubMed:18042044, PubMed:18359941, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694). Mediates the selective degradation of short-lived and abnormal proteins (PubMed:26475854, PubMed:10329681, PubMed:18042044, PubMed:18359941, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694). Functions in the E6/E6-AP-induced ubiquitination of p53/TP53 (PubMed:15280377). Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6 (PubMed:18359941). Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection (PubMed:18703417, PubMed:20403326). Essential for viral activation of IRF3 (PubMed:19854139). {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:15280377, ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:18703417, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20403326, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:26475854}.		protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein modification process [GO:0036211]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein modification process [GO:0036211]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	
P62841	reviewed	RS15_HUMAN	Small ribosomal subunit protein uS19 (40S ribosomal protein S15) (RIG protein)	RPS15 RIG	Homo sapiens (Human)	145	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). {ECO:0000269|PubMed:23636399}.		cytoplasmic translation [GO:0002181]; osteoblast differentiation [GO:0001649]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; MDM2/MDM4 family protein binding [GO:0097371]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; MDM2/MDM4 family protein binding [GO:0097371]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; cytoplasmic translation [GO:0002181]; osteoblast differentiation [GO:0001649]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P62847	reviewed	RS24_HUMAN	Small ribosomal subunit protein eS24 (40S ribosomal protein S24)	RPS24	Homo sapiens (Human)	133	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for processing of pre-rRNA and maturation of 40S ribosomal subunits (PubMed:18230666). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:18230666, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; erythrocyte homeostasis [GO:0034101]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation initiation factor binding [GO:0031369]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation initiation factor binding [GO:0031369]; cytoplasmic translation [GO:0002181]; erythrocyte homeostasis [GO:0034101]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
P62851	reviewed	RS25_HUMAN	Small ribosomal subunit protein eS25 (40S ribosomal protein S25)	RPS25	Homo sapiens (Human)	125	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). {ECO:0000269|PubMed:23636399}.		cytoplasmic translation [GO:0002181]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P62854	reviewed	RS26_HUMAN	Small ribosomal subunit protein eS26 (40S ribosomal protein S26)	RPS26	Homo sapiens (Human)	115	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688}.		cytoplasmic translation [GO:0002181]; negative regulation of RNA splicing [GO:0033119]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; small ribosomal subunit [GO:0015935]; synapse [GO:0045202]	cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; small ribosomal subunit [GO:0015935]; synapse [GO:0045202]; cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; negative regulation of RNA splicing [GO:0033119]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:P49171}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P49171, ECO:0000269|PubMed:25957688}.
P62857	reviewed	RS28_HUMAN	Small ribosomal subunit protein eS28 (40S ribosomal protein S28)	RPS28	Homo sapiens (Human)	69	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:34516797}.		cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; synapse [GO:0045202]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q6QAT1}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q6QAT1, ECO:0000269|PubMed:25957688}.
P62861	reviewed	RS30_HUMAN	Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein (FAU ubiquitin like and ribosomal protein S30 fusion) [Cleaved into: Ubiquitin-like protein FUBI; Small ribosomal subunit protein eS30 (40S ribosomal protein S30)]	FAU	Homo sapiens (Human)	133	FUNCTION: [Ubiquitin-like protein FUBI]: May have pro-apoptotic activity. {ECO:0000269|PubMed:21550398}.; FUNCTION: [Small ribosomal subunit protein eS30]: Component of the 40S subunit of the ribosome. Contributes to the assembly and function of 40S ribosomal subunits. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34318747}.	MISCELLANEOUS: FAU encodes a fusion protein consisting of the ubiquitin-like protein FUBI at the N terminus and ribosomal protein S30 at the C terminus. {ECO:0000269|PubMed:1326960, ECO:0000305|PubMed:15489334}.; MISCELLANEOUS: [Ubiquitin-like protein FUBI]: Lacks the typical lysine residues that participate in Ub's polyubiquitination. However contains a C-terminal di-glycine signature after its proteolytic separation from ribosomal protein S30 and could theoretically be conjugated onto target proteins. {ECO:0000305}.	antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; small ribosomal subunit [GO:0015935]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; small ribosomal subunit [GO:0015935]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; translation [GO:0006412]	SUBCELLULAR LOCATION: [Small ribosomal subunit protein eS30]: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus {ECO:0000269|PubMed:34318747}.
P62873	reviewed	GBB1_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)	GNB1	Homo sapiens (Human)	340	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.		adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; cell population proliferation [GO:0008283]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to prostaglandin E stimulus [GO:0071380]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; Ras protein signal transduction [GO:0007265]; retina development in camera-type eye [GO:0060041]; sensory perception of taste [GO:0050909]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; protein-containing complex binding [GO:0044877]; signaling receptor complex adaptor activity [GO:0030159]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; synapse [GO:0045202]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; protein-containing complex binding [GO:0044877]; signaling receptor complex adaptor activity [GO:0030159]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; cell population proliferation [GO:0008283]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to prostaglandin E stimulus [GO:0071380]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; Ras protein signal transduction [GO:0007265]; retina development in camera-type eye [GO:0060041]; sensory perception of taste [GO:0050909]; signal transduction [GO:0007165]	
P62875	reviewed	RPAB5_HUMAN	DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog)	POLR2L	Homo sapiens (Human)	67	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.		regulation of transcription by RNA polymerase I [GO:0006356]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; tRNA transcription by RNA polymerase III [GO:0042797]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; zinc ion binding [GO:0008270]; regulation of transcription by RNA polymerase I [GO:0006356]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; tRNA transcription by RNA polymerase III [GO:0042797]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16809778, ECO:0000269|PubMed:9852112}.
P62877	reviewed	RBX1_HUMAN	E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]	RBX1 RNF75 ROC1	Homo sapiens (Human)	108	FUNCTION: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:10230407, PubMed:10579999, PubMed:15983046, PubMed:16678110, PubMed:19112177, PubMed:19679664, PubMed:23455478, PubMed:27565346, PubMed:29769719, PubMed:11961546, PubMed:22748924). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Recruits the E2 ubiquitin-conjugating enzyme CDC34 to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). {ECO:0000269|PubMed:10230407, ECO:0000269|PubMed:10579999, ECO:0000269|PubMed:11027288, ECO:0000269|PubMed:11961546, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:16751180, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:19679664, ECO:0000269|PubMed:19920177, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:29769719}.		cellular response to amino acid stimulus [GO:0071230]; cellular response to chemical stress [GO:0062197]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of type I interferon production [GO:0032480]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of TORC1 signaling [GO:1904263]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein neddylation [GO:0045116]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; spermatogenesis [GO:0007283]; T cell activation [GO:0042110]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; Cul5-RING ubiquitin ligase complex [GO:0031466]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	cullin family protein binding [GO:0097602]; molecular adaptor activity [GO:0060090]; NEDD8 ligase activity [GO:0061663]; NEDD8 transferase activity [GO:0019788]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; Cul5-RING ubiquitin ligase complex [GO:0031466]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; cullin family protein binding [GO:0097602]; molecular adaptor activity [GO:0060090]; NEDD8 ligase activity [GO:0061663]; NEDD8 transferase activity [GO:0019788]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270]; cellular response to amino acid stimulus [GO:0071230]; cellular response to chemical stress [GO:0062197]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of type I interferon production [GO:0032480]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of TORC1 signaling [GO:1904263]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein neddylation [GO:0045116]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; spermatogenesis [GO:0007283]; T cell activation [GO:0042110]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11027288}. Nucleus {ECO:0000269|PubMed:11027288}.
P62879	reviewed	GBB2_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2)	GNB2	Homo sapiens (Human)	340	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.		G protein-coupled receptor signaling pathway [GO:0007186]; regulation of potassium ion transmembrane transport [GO:1901379]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; protein-containing complex binding [GO:0044877]; signaling receptor complex adaptor activity [GO:0030159]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; protein-containing complex binding [GO:0044877]; signaling receptor complex adaptor activity [GO:0030159]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of potassium ion transmembrane transport [GO:1901379]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:16498633}. Cell membrane {ECO:0000269|PubMed:28219978}.
P62888	reviewed	RL30_HUMAN	Large ribosomal subunit protein eL30 (60S ribosomal protein L30)	RPL30	Homo sapiens (Human)	115	FUNCTION: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-negative bacterium [GO:0050829]; killing of cells of another organism [GO:0031640]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; postsynaptic density [GO:0014069]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; postsynaptic density [GO:0014069]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-negative bacterium [GO:0050829]; killing of cells of another organism [GO:0031640]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P62891	reviewed	RL39_HUMAN	Large ribosomal subunit protein eL39 (60S ribosomal protein L39)	RPL39	Homo sapiens (Human)	51	FUNCTION: RNA-binding component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:8764829}.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; translation [GO:0006412]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular space [GO:0005615]; polysomal ribosome [GO:0042788]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular space [GO:0005615]; polysomal ribosome [GO:0042788]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P62899	reviewed	RL31_HUMAN	Large ribosomal subunit protein eL31 (60S ribosomal protein L31)	RPL31	Homo sapiens (Human)	125	FUNCTION: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P62906	reviewed	RL10A_HUMAN	Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6)	RPL10A NEDD6	Homo sapiens (Human)	217	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P62910	reviewed	RL32_HUMAN	Large ribosomal subunit protein eL32 (60S ribosomal protein L32)	RPL32 PP9932	Homo sapiens (Human)	135	FUNCTION: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; synapse [GO:0045202]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P62913	reviewed	RL11_HUMAN	Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12)	RPL11	Homo sapiens (Human)	178	FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:32669547, PubMed:19191325). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:32669547, PubMed:19191325). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:32669547, PubMed:19191325). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:32669547, PubMed:19191325). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity). {ECO:0000250|UniProtKB:Q9CXW4, ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:19191325, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein neddylation [GO:2000435]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of protein binding [GO:0032092]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; protein-containing complex [GO:0032991]	5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; protein-containing complex [GO:0032991]; 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625]; cytoplasmic translation [GO:0002181]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein neddylation [GO:2000435]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of protein binding [GO:0032092]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:27829214}. Cytoplasm {ECO:0000250|UniProtKB:Q9CXW4}.
P62917	reviewed	RL8_HUMAN	Large ribosomal subunit protein uL2 (60S ribosomal protein L8)	RPL8	Homo sapiens (Human)	257	FUNCTION: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.	MISCELLANEOUS: This protein can be partially incorporated into E.coli polysomes in vivo, indicating it can replace the endogenous protein.	cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P62937	reviewed	PPIA_HUMAN	Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]	PPIA CYPA	Homo sapiens (Human)	165	FUNCTION: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:25678563, PubMed:21593166). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:30328013, PubMed:22347431). {ECO:0000250|UniProtKB:P17742, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:15130913, ECO:0000269|PubMed:19207730, ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:22347431, ECO:0000269|PubMed:23180369, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:30328013, ECO:0000269|PubMed:31063815}.; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292). {ECO:0000269|PubMed:15688292}.; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. {ECO:0000269|PubMed:21593166}.		activation of protein kinase B activity [GO:0032148]; apoptotic process [GO:0006915]; cell adhesion molecule production [GO:0060352]; cellular response to oxidative stress [GO:0034599]; endothelial cell activation [GO:0042118]; leukocyte chemotaxis [GO:0030595]; lipid droplet organization [GO:0034389]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein K48-linked ubiquitination [GO:0061944]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of viral life cycle [GO:1903901]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of viral genome replication [GO:0045069]; viral release from host cell [GO:0019076]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982]	cyclosporin A binding [GO:0016018]; heparan sulfate binding [GO:1904399]; integrin binding [GO:0005178]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; virion binding [GO:0046790]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982]; cyclosporin A binding [GO:0016018]; heparan sulfate binding [GO:1904399]; integrin binding [GO:0005178]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; virion binding [GO:0046790]; activation of protein kinase B activity [GO:0032148]; apoptotic process [GO:0006915]; cell adhesion molecule production [GO:0060352]; cellular response to oxidative stress [GO:0034599]; endothelial cell activation [GO:0042118]; leukocyte chemotaxis [GO:0030595]; lipid droplet organization [GO:0034389]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein K48-linked ubiquitination [GO:0061944]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of viral life cycle [GO:1903901]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of viral genome replication [GO:0045069]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26095851}. Secreted {ECO:0000269|PubMed:16527992}. Nucleus {ECO:0000269|PubMed:25678563}. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that includes Rho GTPase signaling, actin remodeling, and myosin II activation. {ECO:0000269|PubMed:16527992}.
P62942	reviewed	FKB1A_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)	FKBP1A FKBP1 FKBP12	Homo sapiens (Human)	108	FUNCTION: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000269|PubMed:16720724, ECO:0000269|PubMed:1696686, ECO:0000269|PubMed:1701173, ECO:0000269|PubMed:9233797}.		'de novo' protein folding [GO:0006458]; amyloid fibril formation [GO:1990000]; calcium ion transmembrane transport [GO:0070588]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein binding [GO:0032092]; protein folding [GO:0006457]; protein maturation by protein folding [GO:0022417]; protein peptidyl-prolyl isomerization [GO:0000413]; protein refolding [GO:0042026]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of immune response [GO:0050776]; regulation of protein localization [GO:0032880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; supramolecular fiber organization [GO:0097435]; T cell activation [GO:0042110]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	cytoplasm [GO:0005737]; cytoplasmic side of membrane [GO:0098562]; cytosol [GO:0005829]; membrane [GO:0016020]; ryanodine receptor complex [GO:1990425]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; terminal cisterna [GO:0014802]; Z disc [GO:0030018]	activin receptor binding [GO:0070697]; FK506 binding [GO:0005528]; I-SMAD binding [GO:0070411]; macrolide binding [GO:0005527]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; signaling receptor inhibitor activity [GO:0030547]; transforming growth factor beta receptor binding [GO:0005160]; transmembrane transporter binding [GO:0044325]; type I transforming growth factor beta receptor binding [GO:0034713]	cytoplasm [GO:0005737]; cytoplasmic side of membrane [GO:0098562]; cytosol [GO:0005829]; membrane [GO:0016020]; ryanodine receptor complex [GO:1990425]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; terminal cisterna [GO:0014802]; Z disc [GO:0030018]; activin receptor binding [GO:0070697]; FK506 binding [GO:0005528]; I-SMAD binding [GO:0070411]; macrolide binding [GO:0005527]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; signaling receptor inhibitor activity [GO:0030547]; transforming growth factor beta receptor binding [GO:0005160]; transmembrane transporter binding [GO:0044325]; type I transforming growth factor beta receptor binding [GO:0034713]; 'de novo' protein folding [GO:0006458]; amyloid fibril formation [GO:1990000]; calcium ion transmembrane transport [GO:0070588]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein binding [GO:0032092]; protein folding [GO:0006457]; protein maturation by protein folding [GO:0022417]; protein peptidyl-prolyl isomerization [GO:0000413]; protein refolding [GO:0042026]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of immune response [GO:0050776]; regulation of protein localization [GO:0032880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; supramolecular fiber organization [GO:0097435]; T cell activation [GO:0042110]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1701173}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P62943}; Peripheral membrane protein {ECO:0000250|UniProtKB:P62943}; Cytoplasmic side {ECO:0000250|UniProtKB:P62943}.
P62945	reviewed	RL41_HUMAN	Large ribosomal subunit protein eL41 (60S ribosomal protein L41) (HG12)	RPL41	Homo sapiens (Human)	25	FUNCTION: Component of the large ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII (PubMed:9299532). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:9299532}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; polysomal ribosome [GO:0042788]	mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; polysomal ribosome [GO:0042788]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P62952	reviewed	BLCAP_HUMAN	Bladder cancer-associated protein (Bladder cancer 10 kDa protein) (Bc10)	BLCAP BC10	Homo sapiens (Human)	87	FUNCTION: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. {ECO:0000269|PubMed:17031575}.		apoptotic nuclear changes [GO:0030262]; cell cycle [GO:0007049]	membrane [GO:0016020]		membrane [GO:0016020]; apoptotic nuclear changes [GO:0030262]; cell cycle [GO:0007049]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P62955	reviewed	CCG7_HUMAN	Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage-gated calcium channel gamma-7 subunit) (Transmembrane AMPAR regulatory protein gamma-7) (TARP gamma-7)	CACNG7	Homo sapiens (Human)	275	FUNCTION: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2 (PubMed:21172611). {ECO:0000269|PubMed:21127204, ECO:0000269|PubMed:21172611}.		calcium ion transport [GO:0006816]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of dendrite extension [GO:1903861]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA receptor activity [GO:2000311]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of mRNA stability [GO:0043488]; transmission of nerve impulse [GO:0019226]	AMPA glutamate receptor complex [GO:0032281]; cerebellar mossy fiber [GO:0044300]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; L-type voltage-gated calcium channel complex [GO:1990454]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; voltage-gated calcium channel complex [GO:0005891]	calcium channel regulator activity [GO:0005246]; channel regulator activity [GO:0016247]; voltage-gated calcium channel activity [GO:0005245]	AMPA glutamate receptor complex [GO:0032281]; cerebellar mossy fiber [GO:0044300]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; L-type voltage-gated calcium channel complex [GO:1990454]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; voltage-gated calcium channel complex [GO:0005891]; calcium channel regulator activity [GO:0005246]; channel regulator activity [GO:0016247]; voltage-gated calcium channel activity [GO:0005245]; calcium ion transport [GO:0006816]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of dendrite extension [GO:1903861]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA receptor activity [GO:2000311]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of mRNA stability [GO:0043488]; transmission of nerve impulse [GO:0019226]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:21127204}; Multi-pass membrane protein {ECO:0000305}.
P62979	reviewed	RS27A_HUMAN	Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)]	RPS27A UBA80 UBCEP1	Homo sapiens (Human)	156	FUNCTION: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}.	MISCELLANEOUS: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.; MISCELLANEOUS: For a better understanding, features related to ubiquitin are only indicated for the first chain.	cytoplasmic translation [GO:0002181]; modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; vesicle [GO:0031982]	metal ion binding [GO:0046872]; protein tag activity [GO:0031386]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; vesicle [GO:0031982]; metal ion binding [GO:0046872]; protein tag activity [GO:0031386]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625]; cytoplasmic translation [GO:0002181]; modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567]; translation [GO:0006412]	SUBCELLULAR LOCATION: [Small ribosomal subunit protein eS31]: Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.; SUBCELLULAR LOCATION: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
P62987	reviewed	RL40_HUMAN	Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40)]	UBA52 UBCEP2	Homo sapiens (Human)	128	FUNCTION: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.	MISCELLANEOUS: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.; MISCELLANEOUS: For a better understanding, features related to ubiquitin are only indicated for the first chain.	cytoplasmic translation [GO:0002181]; modification-dependent protein catabolic process [GO:0019941]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; vesicle [GO:0031982]	protein tag activity [GO:0031386]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; vesicle [GO:0031982]; protein tag activity [GO:0031386]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625]; cytoplasmic translation [GO:0002181]; modification-dependent protein catabolic process [GO:0019941]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.; SUBCELLULAR LOCATION: [Large ribosomal subunit protein eL40]: Cytoplasm {ECO:0000250}.
P62993	reviewed	GRB2_HUMAN	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)	GRB2 ASH	Homo sapiens (Human)	217	FUNCTION: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. {ECO:0000269|PubMed:1322798, ECO:0000269|PubMed:19815557}.; FUNCTION: [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. {ECO:0000269|PubMed:8178156}.		actin cytoskeleton organization [GO:0030036]; B cell receptor signaling pathway [GO:0050853]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cellular response to ionizing radiation [GO:0071479]; endodermal cell differentiation [GO:0035987]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]	cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Grb2-EGFR complex [GO:0070436]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]	ephrin receptor binding [GO:0046875]; epidermal growth factor receptor binding [GO:0005154]; guanyl-nucleotide exchange factor adaptor activity [GO:0005091]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; neurotrophin TRKA receptor binding [GO:0005168]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Grb2-EGFR complex [GO:0070436]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; ephrin receptor binding [GO:0046875]; epidermal growth factor receptor binding [GO:0005154]; guanyl-nucleotide exchange factor adaptor activity [GO:0005091]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; neurotrophin TRKA receptor binding [GO:0005168]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; actin cytoskeleton organization [GO:0030036]; B cell receptor signaling pathway [GO:0050853]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cellular response to ionizing radiation [GO:0071479]; endodermal cell differentiation [GO:0035987]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21179510}. Cytoplasm {ECO:0000269|PubMed:21179510}. Endosome {ECO:0000269|PubMed:21179510}. Golgi apparatus {ECO:0000250|UniProtKB:Q60631}.
P62995	reviewed	TRA2B_HUMAN	Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)	TRA2B SFRS10	Homo sapiens (Human)	288	FUNCTION: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}.		cellular response to glucose stimulus [GO:0071333]; cerebral cortex regionalization [GO:0021796]; embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing, via transesterification reactions [GO:0000375]	nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]	identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]	nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; cellular response to glucose stimulus [GO:0071333]; cerebral cortex regionalization [GO:0021796]; embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9212162, ECO:0000269|PubMed:9546399}.
P63000	reviewed	RAC1_HUMAN	Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)	RAC1 TC25 MIG5	Homo sapiens (Human)	192	FUNCTION: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles (PubMed:1643658, PubMed:28886345, PubMed:23512198). Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed:9121475). In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:1643658). In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In neurons, is involved in dendritic spine formation and synaptic plasticity (By similarity). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (PubMed:12695502). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (By similarity). {ECO:0000250|UniProtKB:P63001, ECO:0000250|UniProtKB:Q6RUV5, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:1643658, ECO:0000269|PubMed:23512198, ECO:0000269|PubMed:28886345, ECO:0000269|PubMed:9121475}.; FUNCTION: [Isoform B]: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins (PubMed:14625275). It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction (PubMed:14625275). {ECO:0000269|PubMed:14625275}.		actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell motility [GO:0048870]; cell projection assembly [GO:0030031]; cell-matrix adhesion [GO:0007160]; cortical cytoskeleton organization [GO:0030865]; engulfment of apoptotic cell [GO:0043652]; establishment or maintenance of cell polarity [GO:0007163]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; localization [GO:0051179]; localization within membrane [GO:0051668]; motor neuron axon guidance [GO:0008045]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of interleukin-23 production [GO:0032707]; negative regulation of receptor-mediated endocytosis [GO:0048261]; neuron migration [GO:0001764]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; Rac protein signal transduction [GO:0016601]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of lamellipodium assembly [GO:0010591]; regulation of neutrophil migration [GO:1902622]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of respiratory burst [GO:0060263]; regulation of stress fiber assembly [GO:0051492]; respiratory burst [GO:0045730]; response to wounding [GO:0009611]; ruffle assembly [GO:0097178]; ruffle organization [GO:0031529]; semaphorin-plexin signaling pathway [GO:0071526]; small GTPase mediated signal transduction [GO:0007264]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; substrate adhesion-dependent cell spreading [GO:0034446]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; recycling endosome membrane [GO:0055038]; ruffle membrane [GO:0032587]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]	enzyme binding [GO:0019899]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; Rho GDP-dissociation inhibitor binding [GO:0051022]; thioesterase binding [GO:0031996]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; recycling endosome membrane [GO:0055038]; ruffle membrane [GO:0032587]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; enzyme binding [GO:0019899]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; Rho GDP-dissociation inhibitor binding [GO:0051022]; thioesterase binding [GO:0031996]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell motility [GO:0048870]; cell projection assembly [GO:0030031]; cell-matrix adhesion [GO:0007160]; cortical cytoskeleton organization [GO:0030865]; engulfment of apoptotic cell [GO:0043652]; establishment or maintenance of cell polarity [GO:0007163]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; localization [GO:0051179]; localization within membrane [GO:0051668]; motor neuron axon guidance [GO:0008045]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of interleukin-23 production [GO:0032707]; negative regulation of receptor-mediated endocytosis [GO:0048261]; neuron migration [GO:0001764]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; Rac protein signal transduction [GO:0016601]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of lamellipodium assembly [GO:0010591]; regulation of neutrophil migration [GO:1902622]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of respiratory burst [GO:0060263]; regulation of stress fiber assembly [GO:0051492]; respiratory burst [GO:0045730]; response to wounding [GO:0009611]; ruffle assembly [GO:0097178]; ruffle organization [GO:0031529]; semaphorin-plexin signaling pathway [GO:0071526]; small GTPase mediated signal transduction [GO:0007264]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; substrate adhesion-dependent cell spreading [GO:0034446]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1643658, ECO:0000269|PubMed:29074776}; Lipid-anchor {ECO:0000269|PubMed:1903399}; Cytoplasmic side {ECO:0000269|PubMed:1643658, ECO:0000269|PubMed:19948726}. Melanosome {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:19948726, ECO:0000269|PubMed:21693584}. Cytoplasm {ECO:0000269|PubMed:19948726, ECO:0000269|PubMed:29074776}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P63001}. Cell projection, dendrite {ECO:0000250|UniProtKB:P63001}. Synapse {ECO:0000250|UniProtKB:Q6RUV5}. Nucleus {ECO:0000269|PubMed:12551911}. Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (PubMed:1903399). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Localizes to the lamellipodium in a SH3RF1-dependent manner (By similarity). In macrophages, cytoplasmic location increases upon CSF1 stimulation (By similarity). Activation by GTP-binding promotes nuclear localization (PubMed:12551911). {ECO:0000250|UniProtKB:P63001, ECO:0000250|UniProtKB:Q6RUV5, ECO:0000269|PubMed:12551911, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:1903399}.
P63010	reviewed	AP2B1_HUMAN	AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)	AP2B1 ADTB2 CLAPB1	Homo sapiens (Human)	937	FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. {ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}.	MISCELLANEOUS: [Isoform 3]: Highly expressed in the testis, spleen, thymus, prostate, ovary, blood leukocyte and brain, but not in the heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Testis expression is restricted to germ cells and is about 3-fold higher in adults than in embryos. {ECO:0000305}.	aorta development [GO:0035904]; clathrin-dependent endocytosis [GO:0072583]; coronary vasculature development [GO:0060976]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; synaptic vesicle endocytosis [GO:0048488]; ventricular septum development [GO:0003281]; vesicle-mediated transport [GO:0016192]	AP-2 adaptor complex [GO:0030122]; clathrin adaptor complex [GO:0030131]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]	clathrin binding [GO:0030276]; signal sequence binding [GO:0005048]	AP-2 adaptor complex [GO:0030122]; clathrin adaptor complex [GO:0030131]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; clathrin binding [GO:0030276]; signal sequence binding [GO:0005048]; aorta development [GO:0035904]; clathrin-dependent endocytosis [GO:0072583]; coronary vasculature development [GO:0060976]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; synaptic vesicle endocytosis [GO:0048488]; ventricular septum development [GO:0003281]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14530274}. Membrane, coated pit {ECO:0000269|PubMed:14530274}; Peripheral membrane protein {ECO:0000269|PubMed:14530274}; Cytoplasmic side {ECO:0000269|PubMed:14530274}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.
P63027	reviewed	VAMP2_HUMAN	Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)	VAMP2 SYB2	Homo sapiens (Human)	116	FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:P63044, ECO:0000250|UniProtKB:P63045, ECO:0000269|PubMed:30929742}.		calcium-ion regulated exocytosis [GO:0017156]; cellular response to insulin stimulus [GO:0032869]; eosinophil degranulation [GO:0043308]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; long-term synaptic potentiation [GO:0060291]; membrane fusion [GO:0061025]; positive regulation of intracellular protein transport [GO:0090316]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; regulation of delayed rectifier potassium channel activity [GO:1902259]; regulation of exocytosis [GO:0017157]; regulation of vesicle-mediated transport [GO:0060627]; response to glucose [GO:0009749]; SNARE complex assembly [GO:0035493]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]	clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; SNARE complex [GO:0031201]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [GO:0070032]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [GO:0070033]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982]; zymogen granule membrane [GO:0042589]	calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; phospholipid binding [GO:0005543]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]	clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; SNARE complex [GO:0031201]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [GO:0070032]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [GO:0070033]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982]; zymogen granule membrane [GO:0042589]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; phospholipid binding [GO:0005543]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]; calcium-ion regulated exocytosis [GO:0017156]; cellular response to insulin stimulus [GO:0032869]; eosinophil degranulation [GO:0043308]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; long-term synaptic potentiation [GO:0060291]; membrane fusion [GO:0061025]; positive regulation of intracellular protein transport [GO:0090316]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; regulation of delayed rectifier potassium channel activity [GO:1902259]; regulation of exocytosis [GO:0017157]; regulation of vesicle-mediated transport [GO:0060627]; response to glucose [GO:0009749]; SNARE complex assembly [GO:0035493]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:17313651}; Single-pass type IV membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P63045}. Note=Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651). {ECO:0000269|PubMed:17313651}.
P63092	reviewed	GNAS2_HUMAN	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)	GNAS GNAS1 GSP	Homo sapiens (Human)	394	FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161). {ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:17110384, ECO:0000269|PubMed:21488135, ECO:0000269|PubMed:26206488, ECO:0000269|PubMed:8702665}.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the ALEX protein from an overlapping reading frame.; MISCELLANEOUS: The GNAS locus is imprinted in a complex manner, giving rise to distinct paternally, maternally and biallelically expressed proteins. The XLas isoforms are paternally derived, the Gnas isoforms are biallelically derived and the Nesp55 isoforms are maternally derived.	activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone development [GO:0060348]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to prostaglandin E stimulus [GO:0071380]; cognition [GO:0050890]; developmental growth [GO:0048589]; hair follicle placode formation [GO:0060789]; intracellular transport [GO:0046907]; platelet aggregation [GO:0070527]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of GTPase activity [GO:0043547]; sensory perception of smell [GO:0007608]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	adenylate cyclase activator activity [GO:0010856]; D1 dopamine receptor binding [GO:0031748]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; adenylate cyclase activator activity [GO:0010856]; D1 dopamine receptor binding [GO:0031748]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone development [GO:0060348]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to prostaglandin E stimulus [GO:0071380]; cognition [GO:0050890]; developmental growth [GO:0048589]; hair follicle placode formation [GO:0060789]; intracellular transport [GO:0046907]; platelet aggregation [GO:0070527]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of GTPase activity [GO:0043547]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P63094}; Lipid-anchor {ECO:0000250|UniProtKB:P63094}.
P63096	reviewed	GNAI1_HUMAN	Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)	GNAI1	Homo sapiens (Human)	354	FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). {ECO:0000250|UniProtKB:P10824, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:8774883}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to forskolin [GO:1904322]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of protein localization to cell cortex [GO:1904778]; regulation of cAMP-mediated signaling [GO:0043949]; regulation of mitotic spindle organization [GO:0060236]; response to peptide hormone [GO:0043434]	cell cortex [GO:0005938]; cell cortex region [GO:0099738]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	D2 dopamine receptor binding [GO:0031749]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled serotonin receptor binding [GO:0031821]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	cell cortex [GO:0005938]; cell cortex region [GO:0099738]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; D2 dopamine receptor binding [GO:0031749]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled serotonin receptor binding [GO:0031821]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to forskolin [GO:1904322]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of protein localization to cell cortex [GO:1904778]; regulation of cAMP-mediated signaling [GO:0043949]; regulation of mitotic spindle organization [GO:0060236]; response to peptide hormone [GO:0043434]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10824}. Cytoplasm {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:26766442}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10824}; Cytoplasmic side {ECO:0000250|UniProtKB:P10824}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Cytoplasm, cell cortex {ECO:0000269|PubMed:22327364}. Membrane {ECO:0000250|UniProtKB:P10824}; Lipid-anchor {ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805}. Note=Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody (PubMed:17635935). Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane. {ECO:0000250|UniProtKB:P10824, ECO:0000269|PubMed:17635935}.
P63098	reviewed	CANB1_HUMAN	Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)	PPP3R1 CNA2 CNB	Homo sapiens (Human)	170	FUNCTION: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. {ECO:0000269|PubMed:26794871}.	MISCELLANEOUS: This protein has four functional calcium-binding sites (PubMed:8524402, PubMed:12218175, PubMed:12357034, PubMed:17498738, PubMed:22343722, PubMed:23468591, PubMed:26794871, PubMed:27974827). Although African swine fever virus infects pigs and not humans, human PPP3R1 and PPP3CA have been used for the crystallization. PPP3CA and PPP3R1 interact with African swine fever virus Mal-047/A238L (via PKIIIT and FLCVK motifs); the interaction does not block catalytic activity per se but inhibits PPP3CA function by blocking the access to the two substrate recognition (PubMed:23468591). {ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402}.	branching involved in blood vessel morphogenesis [GO:0001569]; calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; epithelial to mesenchymal transition [GO:0001837]; heart development [GO:0007507]; lung epithelial cell differentiation [GO:0060487]; myelination in peripheral nervous system [GO:0022011]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein import into nucleus [GO:0006606]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of synaptic vesicle cycle [GO:0098693]	calcineurin complex [GO:0005955]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nucleoplasm [GO:0005654]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynapse [GO:0098794]; protein serine/threonine phosphatase complex [GO:0008287]; sarcolemma [GO:0042383]; Schaffer collateral - CA1 synapse [GO:0098685]	calcium ion binding [GO:0005509]; calcium-dependent protein serine/threonine phosphatase activity [GO:0004723]; calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; calmodulin binding [GO:0005516]; cyclosporin A binding [GO:0016018]; phosphatase binding [GO:0019902]; protein domain specific binding [GO:0019904]	calcineurin complex [GO:0005955]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nucleoplasm [GO:0005654]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynapse [GO:0098794]; protein serine/threonine phosphatase complex [GO:0008287]; sarcolemma [GO:0042383]; Schaffer collateral - CA1 synapse [GO:0098685]; calcium ion binding [GO:0005509]; calcium-dependent protein serine/threonine phosphatase activity [GO:0004723]; calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; calmodulin binding [GO:0005516]; cyclosporin A binding [GO:0016018]; phosphatase binding [GO:0019902]; protein domain specific binding [GO:0019904]; branching involved in blood vessel morphogenesis [GO:0001569]; calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; epithelial to mesenchymal transition [GO:0001837]; heart development [GO:0007507]; lung epithelial cell differentiation [GO:0060487]; myelination in peripheral nervous system [GO:0022011]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein import into nucleus [GO:0006606]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of synaptic vesicle cycle [GO:0098693]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q63810}. Cell membrane {ECO:0000250|UniProtKB:Q63810}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q63810}. Cell membrane {ECO:0000269|PubMed:25255805}; Lipid-anchor {ECO:0000269|PubMed:25255805}. Note=Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy. {ECO:0000250|UniProtKB:Q63810}.
P63104	reviewed	1433Z_HUMAN	14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)	YWHAZ	Homo sapiens (Human)	245	FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}.		cellular response to glucose starvation [GO:0042149]; establishment of Golgi localization [GO:0051683]; Golgi reassembly [GO:0090168]; negative regulation of apoptotic process [GO:0043066]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein phosphorylation [GO:0006468]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of synapse maturation [GO:0090128]; signal transduction [GO:0007165]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; melanosome [GO:0042470]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; vesicle [GO:0031982]	cadherin binding [GO:0045296]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; phosphoserine residue binding [GO:0050815]; protein kinase binding [GO:0019901]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; melanosome [GO:0042470]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; phosphoserine residue binding [GO:0050815]; protein kinase binding [GO:0019901]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; cellular response to glucose starvation [GO:0042149]; establishment of Golgi localization [GO:0051683]; Golgi reassembly [GO:0090168]; negative regulation of apoptotic process [GO:0043066]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein phosphorylation [GO:0006468]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of synapse maturation [GO:0090128]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Located to stage I to stage IV melanosomes. {ECO:0000269|PubMed:17081065}.
P63128	reviewed	POK9_HUMAN	Endogenous retrovirus group K member 9 Pol protein (HERV-K(C6) Gag-Pol protein) (HERV-K109 Gag-Pol protein) (HERV-K_6q14.1 provirus ancestral Gag-Pol polyprotein) [Includes: Protease (EC 3.4.23.50) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p66 RT)]	ERVK-9	Homo sapiens (Human)	1117	FUNCTION: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution (By similarity). {ECO:0000250}.; FUNCTION: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity). {ECO:0000250}.		proteolysis [GO:0006508]; viral process [GO:0016032]	plasma membrane [GO:0005886]	aspartic-type endopeptidase activity [GO:0004190]; DNA-directed DNA polymerase activity [GO:0003887]; RNA binding [GO:0003723]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]; aspartic-type endopeptidase activity [GO:0004190]; DNA-directed DNA polymerase activity [GO:0003887]; RNA binding [GO:0003723]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cell membrane. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.
P63146	reviewed	UBE2B_HUMAN	Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (hHR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2-17 kDa) (Ubiquitin-protein ligase B)	UBE2B RAD6B	Homo sapiens (Human)	152	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth. {ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289, ECO:0000269|PubMed:1717990, ECO:0000269|PubMed:20061386}.		apoptotic process [GO:0006915]; chiasma assembly [GO:0051026]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; ectopic germ cell programmed cell death [GO:0035234]; in utero embryonic development [GO:0001701]; meiotic telomere clustering [GO:0045141]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of developmental process [GO:0051093]; negative regulation of post-translational protein modification [GO:1901874]; negative regulation of reproductive process [GO:2000242]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of reciprocal meiotic recombination [GO:0010845]; postreplication repair [GO:0006301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; response to UV [GO:0009411]; response to xenobiotic stimulus [GO:0009410]; sperm axoneme assembly [GO:0007288]; spermatogenesis [GO:0007283]; synaptonemal complex organization [GO:0070193]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; HULC complex [GO:0033503]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; replication fork [GO:0005657]; XY body [GO:0001741]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; HULC complex [GO:0033503]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; replication fork [GO:0005657]; XY body [GO:0001741]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; chiasma assembly [GO:0051026]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; ectopic germ cell programmed cell death [GO:0035234]; in utero embryonic development [GO:0001701]; meiotic telomere clustering [GO:0045141]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of developmental process [GO:0051093]; negative regulation of post-translational protein modification [GO:1901874]; negative regulation of reproductive process [GO:2000242]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of reciprocal meiotic recombination [GO:0010845]; postreplication repair [GO:0006301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; response to UV [GO:0009411]; response to xenobiotic stimulus [GO:0009410]; sperm axoneme assembly [GO:0007288]; spermatogenesis [GO:0007283]; synaptonemal complex organization [GO:0070193]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P63149}. Nucleus {ECO:0000250|UniProtKB:P63149}. Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei. {ECO:0000250|UniProtKB:P63149}.
P63151	reviewed	2ABA_HUMAN	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha)	PPP2R2A	Homo sapiens (Human)	447	FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:33108758}.		protein dephosphorylation [GO:0006470]; response to morphine [GO:0043278]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase regulator activity [GO:0019888]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; protein phosphatase type 2A complex [GO:0000159]; protein phosphatase regulator activity [GO:0019888]; protein dephosphorylation [GO:0006470]; response to morphine [GO:0043278]	
P63162	reviewed	RSMN_HUMAN	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein D) (Sm-D) (Sm protein N) (Sm-N) (SmN) (Tissue-specific-splicing protein)	SNRPN HCERN3 SMN	Homo sapiens (Human)	240	FUNCTION: May be involved in tissue-specific alternative RNA processing events.	MISCELLANEOUS: Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.; MISCELLANEOUS: Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. N bears Sm epitopes.	mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; small nuclear ribonucleoprotein complex [GO:0030532]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; small nuclear ribonucleoprotein complex [GO:0030532]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus.
P63165	reviewed	SUMO1_HUMAN	Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)	SUMO1 SMT3C SMT3H3 UBL1 OK/SW-cl.43	Homo sapiens (Human)	101	FUNCTION: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}.		cellular response to cadmium ion [GO:0071276]; cellular response to heat [GO:0034605]; DNA repair [GO:0006281]; negative regulation of action potential [GO:0045759]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by transcription factor localization [GO:0010621]; PML body organization [GO:0030578]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to nuclear pore [GO:0090204]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of protein localization [GO:0032880]; roof of mouth development [GO:0060021]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear speck [GO:0016607]; nuclear stress granule [GO:0097165]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; XY body [GO:0001741]	enzyme binding [GO:0019899]; potassium channel regulator activity [GO:0015459]; protein tag activity [GO:0031386]; RNA binding [GO:0003723]; small protein activating enzyme binding [GO:0044388]; transcription factor binding [GO:0008134]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-specific protease binding [GO:1990381]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear speck [GO:0016607]; nuclear stress granule [GO:0097165]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; XY body [GO:0001741]; enzyme binding [GO:0019899]; potassium channel regulator activity [GO:0015459]; protein tag activity [GO:0031386]; RNA binding [GO:0003723]; small protein activating enzyme binding [GO:0044388]; transcription factor binding [GO:0008134]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-specific protease binding [GO:1990381]; cellular response to cadmium ion [GO:0071276]; cellular response to heat [GO:0034605]; DNA repair [GO:0006281]; negative regulation of action potential [GO:0045759]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by transcription factor localization [GO:0010621]; PML body organization [GO:0030578]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to nuclear pore [GO:0090204]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of protein localization [GO:0032880]; roof of mouth development [GO:0060021]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:10574707, ECO:0000269|PubMed:12383504}. Nucleus speckle {ECO:0000250|UniProtKB:P63166}. Cytoplasm {ECO:0000269|PubMed:12383504, ECO:0000269|PubMed:9162015}. Nucleus, PML body {ECO:0000269|PubMed:10574707, ECO:0000269|PubMed:12383504, ECO:0000269|PubMed:22406621}. Cell membrane {ECO:0000269|PubMed:19223394}. Nucleus {ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9162015}. Note=Recruited by BCL11A into the nuclear body (By similarity). In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body (PubMed:24651376). {ECO:0000250|UniProtKB:P63166, ECO:0000269|PubMed:24651376}.
P63167	reviewed	DYL1_HUMAN	Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)	DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1	Homo sapiens (Human)	89	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.; FUNCTION: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. {ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16684779}.; FUNCTION: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. {ECO:0000269|PubMed:10198631, ECO:0000269|PubMed:15193260}.; FUNCTION: Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1. {ECO:0000250|UniProtKB:P63170}.		apoptotic process [GO:0006915]; intraciliary retrograde transport [GO:0035721]; motile cilium assembly [GO:0044458]; negative regulation of phosphorylation [GO:0042326]; substantia nigra development [GO:0021762]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dynein complex [GO:0030286]; ficolin-1-rich granule membrane [GO:0101003]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	dynein intermediate chain binding [GO:0045505]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dynein complex [GO:0030286]; ficolin-1-rich granule membrane [GO:0101003]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; dynein intermediate chain binding [GO:0045505]; apoptotic process [GO:0006915]; intraciliary retrograde transport [GO:0035721]; motile cilium assembly [GO:0044458]; negative regulation of phosphorylation [GO:0042326]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20921139}. Nucleus {ECO:0000269|PubMed:15891768}. Mitochondrion {ECO:0000269|PubMed:18084006}. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria. {ECO:0000269|PubMed:18084006}.
P63172	reviewed	DYLT1_HUMAN	Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog)	DYNLT1 TCTEL1 TCTEX-1 TCTEX1	Homo sapiens (Human)	113	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein.; FUNCTION: Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity). Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (PubMed:27502274). {ECO:0000250, ECO:0000269|PubMed:27502274}.; FUNCTION: (Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. {ECO:0000269|PubMed:18647839}.		cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; intracellular transport of viral protein in host cell [GO:0019060]; microtubule-based movement [GO:0007018]; microtubule-dependent intracellular transport of viral material towards nucleus [GO:0075521]; negative regulation of neurogenesis [GO:0050768]; nervous system development [GO:0007399]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; viral entry into host cell [GO:0046718]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytoplasmic microtubule [GO:0005881]; dynein complex [GO:0030286]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; host cell [GO:0043657]; secretory granule lumen [GO:0034774]; secretory vesicle [GO:0099503]; spindle [GO:0005819]	dynein intermediate chain binding [GO:0045505]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytoplasmic microtubule [GO:0005881]; dynein complex [GO:0030286]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; host cell [GO:0043657]; secretory granule lumen [GO:0034774]; secretory vesicle [GO:0099503]; spindle [GO:0005819]; dynein intermediate chain binding [GO:0045505]; identical protein binding [GO:0042802]; cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; intracellular transport of viral protein in host cell [GO:0019060]; microtubule-based movement [GO:0007018]; microtubule-dependent intracellular transport of viral material towards nucleus [GO:0075521]; negative regulation of neurogenesis [GO:0050768]; nervous system development [GO:0007399]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to mitotic spindles. {ECO:0000250}.
P63173	reviewed	RL38_HUMAN	Large ribosomal subunit protein eL38 (60S ribosomal protein L38)	RPL38	Homo sapiens (Human)	70	FUNCTION: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		90S preribosome assembly [GO:0034463]; axial mesoderm development [GO:0048318]; cytoplasmic translation [GO:0002181]; middle ear morphogenesis [GO:0042474]; ossification [GO:0001503]; protein-RNA complex assembly [GO:0022618]; regulation of translation [GO:0006417]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; eukaryotic 80S initiation complex [GO:0033291]; focal adhesion [GO:0005925]; polysomal ribosome [GO:0042788]; postsynaptic density [GO:0014069]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; eukaryotic 80S initiation complex [GO:0033291]; focal adhesion [GO:0005925]; polysomal ribosome [GO:0042788]; postsynaptic density [GO:0014069]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; 90S preribosome assembly [GO:0034463]; axial mesoderm development [GO:0048318]; cytoplasmic translation [GO:0002181]; middle ear morphogenesis [GO:0042474]; ossification [GO:0001503]; protein-RNA complex assembly [GO:0022618]; regulation of translation [GO:0006417]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P63208	reviewed	SKP1_HUMAN	S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)	SKP1 EMC19 OCP2 SKP1A TCEB1L	Homo sapiens (Human)	163	FUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. {ECO:0000269|PubMed:16209941, ECO:0000269|PubMed:20181953, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:28727686}.		chromatin remodeling [GO:0006338]; maintenance of protein location in nucleus [GO:0051457]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	centrosome [GO:0005813]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; SCF ubiquitin ligase complex [GO:0019005]	beta-catenin binding [GO:0008013]; cullin family protein binding [GO:0097602]; F-box domain binding [GO:1990444]; molecular function activator activity [GO:0140677]; protein domain specific binding [GO:0019904]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	centrosome [GO:0005813]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; SCF ubiquitin ligase complex [GO:0019005]; beta-catenin binding [GO:0008013]; cullin family protein binding [GO:0097602]; F-box domain binding [GO:1990444]; molecular function activator activity [GO:0140677]; protein domain specific binding [GO:0019904]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; chromatin remodeling [GO:0006338]; maintenance of protein location in nucleus [GO:0051457]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	
P63211	reviewed	GBG1_HUMAN	Guanine nucleotide-binding protein G(T) subunit gamma-T1 (Transducin gamma chain)	GNGT1	Homo sapiens (Human)	74	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.		cardiac muscle cell apoptotic process [GO:0010659]; cellular response to hypoxia [GO:0071456]; eye photoreceptor cell development [GO:0042462]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; protein localization [GO:0008104]; signal transduction [GO:0007165]	heterotrimeric G-protein complex [GO:0005834]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]	G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]	heterotrimeric G-protein complex [GO:0005834]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to hypoxia [GO:0071456]; eye photoreceptor cell development [GO:0042462]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; protein localization [GO:0008104]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P63218	reviewed	GBG5_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	GNG5 GNGT5	Homo sapiens (Human)	68	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.		G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; plasma membrane [GO:0005886]	G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]; PDZ domain binding [GO:0030165]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; plasma membrane [GO:0005886]; G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]; PDZ domain binding [GO:0030165]; G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P63220	reviewed	RS21_HUMAN	Small ribosomal subunit protein eS21 (40S ribosomal protein S21)	RPS21	Homo sapiens (Human)	83	FUNCTION: Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688}.		cytoplasmic translation [GO:0002181]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000461]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; rough endoplasmic reticulum [GO:0005791]; small ribosomal subunit [GO:0015935]; synapse [GO:0045202]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; rough endoplasmic reticulum [GO:0005791]; small ribosomal subunit [GO:0015935]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000461]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:P63221}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P63221, ECO:0000269|PubMed:25957688}.
P63241	reviewed	IF5A1_HUMAN	Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D)	EIF5A	Homo sapiens (Human)	154	FUNCTION: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:33547280). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (PubMed:16987817). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (PubMed:15371445). Regulates also TNF-alpha-mediated apoptosis (PubMed:15452064, PubMed:17187778). Mediates effects of polyamines on neuronal process extension and survival (PubMed:17360499). {ECO:0000250|UniProtKB:P23301, ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499, ECO:0000269|PubMed:33547280}.; FUNCTION: (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:8253832}.		cellular response to virus [GO:0098586]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; translational elongation [GO:0006414]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear pore [GO:0005643]; nucleus [GO:0005634]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; U6 snRNA binding [GO:0017070]	annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; U6 snRNA binding [GO:0017070]; cellular response to virus [GO:0098586]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; translational elongation [GO:0006414]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10944119, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:19379712, ECO:0000269|PubMed:27306458, ECO:0000269|PubMed:8660923}. Nucleus {ECO:0000269|PubMed:10944119, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:19379712, ECO:0000269|PubMed:27306458, ECO:0000269|PubMed:8253832}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:8660923}; Peripheral membrane protein {ECO:0000269|PubMed:8660923}; Cytoplasmic side {ECO:0000269|PubMed:8660923}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions (PubMed:19379712, PubMed:27306458). Nuclear export of hypusinated protein is mediated by XPO4 (PubMed:10944119, PubMed:27306458). {ECO:0000269|PubMed:10944119, ECO:0000269|PubMed:19379712, ECO:0000269|PubMed:27306458}.
P63244	reviewed	RACK1_HUMAN	Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)]	RACK1 GNB2L1 HLC7 PIG21	Homo sapiens (Human)	317	FUNCTION: Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:12589061, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17108144, ECO:0000269|PubMed:17244529, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18621736, ECO:0000269|PubMed:19423701, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20541605, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:21212275, ECO:0000269|PubMed:21347310, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:9584165}.; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {ECO:0000269|PubMed:21347310}.; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {ECO:0000269|PubMed:11312657}.; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {ECO:0000269|PubMed:28636603}.; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269|PubMed:25416947}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cell cycle [GO:0007049]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cytoplasmic translation [GO:0002181]; gastrulation [GO:0007369]; negative regulation of cell growth [GO:0030308]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of phagocytosis [GO:0050765]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein binding [GO:0032091]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of translation [GO:0017148]; negative regulation of Wnt signaling pathway [GO:0030178]; pigmentation [GO:0043473]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051343]; positive regulation of gastrulation [GO:2000543]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of GTPase activity [GO:0043547]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880]; rescue of stalled ribosome [GO:0072344]; rhythmic process [GO:0048511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; IRE1-RACK1-PP2A complex [GO:1990630]; midbody [GO:0030496]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; small ribosomal subunit [GO:0015935]	BH3 domain binding [GO:0051434]; cadherin binding [GO:0045296]; cyclin binding [GO:0030332]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; enzyme binding [GO:0019899]; ion channel inhibitor activity [GO:0008200]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase inhibitor activity [GO:0030292]; receptor tyrosine kinase binding [GO:0030971]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; translation regulator activity [GO:0045182]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; IRE1-RACK1-PP2A complex [GO:1990630]; midbody [GO:0030496]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; small ribosomal subunit [GO:0015935]; BH3 domain binding [GO:0051434]; cadherin binding [GO:0045296]; cyclin binding [GO:0030332]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; enzyme binding [GO:0019899]; ion channel inhibitor activity [GO:0008200]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase inhibitor activity [GO:0030292]; receptor tyrosine kinase binding [GO:0030971]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; translation regulator activity [GO:0045182]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cell cycle [GO:0007049]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cytoplasmic translation [GO:0002181]; gastrulation [GO:0007369]; negative regulation of cell growth [GO:0030308]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of phagocytosis [GO:0050765]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein binding [GO:0032091]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of translation [GO:0017148]; negative regulation of Wnt signaling pathway [GO:0030178]; pigmentation [GO:0043473]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051343]; positive regulation of gastrulation [GO:2000543]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of GTPase activity [GO:0043547]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880]; rescue of stalled ribosome [GO:0072344]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11312657, ECO:0000269|PubMed:17956333}; Peripheral membrane protein. Cytoplasm {ECO:0000269|PubMed:10849009, ECO:0000269|PubMed:11279199, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:29743600}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11279199, ECO:0000269|PubMed:12958311}. Nucleus {ECO:0000269|PubMed:10849009}. Perikaryon {ECO:0000250|UniProtKB:P68040}. Cell projection, dendrite {ECO:0000250|UniProtKB:P68040}. Cell projection, phagocytic cup {ECO:0000269|PubMed:21347310}. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333). Also associated with the membrane in oncogene-transformed cells (PubMed:11884618). PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11279199, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:21347310}.
P63252	reviewed	KCNJ2_HUMAN	Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2)	KCNJ2 IRK1	Homo sapiens (Human)	427	FUNCTION: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (PubMed:7590287, PubMed:7696590, PubMed:7840300). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:9490857, PubMed:7590287, PubMed:36149965). Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:7696590, PubMed:7590287). The inward rectification is mainly due to the blockage of outward current by internal magnesium (PubMed:9490857). Can be blocked by extracellular barium or cesium (PubMed:7696590, PubMed:7590287). {ECO:0000269|PubMed:36149965, ECO:0000269|PubMed:7590287, ECO:0000269|PubMed:7696590, ECO:0000269|PubMed:7840300, ECO:0000269|PubMed:9490857}.		cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to mechanical stimulus [GO:0071260]; intracellular potassium ion homeostasis [GO:0030007]; magnesium ion transport [GO:0015693]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of resting membrane potential [GO:0060075]; regulation of skeletal muscle contraction via regulation of action potential [GO:0014861]; relaxation of cardiac muscle [GO:0055119]; relaxation of skeletal muscle [GO:0090076]	dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; intercalated disc [GO:0014704]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]	identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008]	dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; intercalated disc [GO:0014704]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]; identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to mechanical stimulus [GO:0071260]; intracellular potassium ion homeostasis [GO:0030007]; magnesium ion transport [GO:0015693]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of resting membrane potential [GO:0060075]; regulation of skeletal muscle contraction via regulation of action potential [GO:0014861]; relaxation of cardiac muscle [GO:0055119]; relaxation of skeletal muscle [GO:0090076]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Membrane; Lipid-anchor {ECO:0000269|PubMed:25043870}.
P63261	reviewed	ACTG_HUMAN	Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]	ACTG1 ACTG	Homo sapiens (Human)	375	FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000305|PubMed:29581253}.	MISCELLANEOUS: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.	angiogenesis [GO:0001525]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; cellular response to type II interferon [GO:0071346]; maintenance of blood-brain barrier [GO:0035633]; morphogenesis of a polarized epithelium [GO:0001738]; platelet aggregation [GO:0070527]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; positive regulation of wound healing [GO:0090303]; protein localization to bicellular tight junction [GO:1902396]; regulation of focal adhesion assembly [GO:0051893]; regulation of stress fiber assembly [GO:0051492]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of transepithelial transport [GO:0150111]; retina homeostasis [GO:0001895]; sarcomere organization [GO:0045214]; tight junction assembly [GO:0120192]	actin filament [GO:0005884]; apical junction complex [GO:0043296]; axon [GO:0030424]; basal body patch [GO:0120220]; blood microparticle [GO:0072562]; calyx of Held [GO:0044305]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dense body [GO:0097433]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; membrane [GO:0016020]; myofibril [GO:0030016]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]	ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; profilin binding [GO:0005522]; protein kinase binding [GO:0019901]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; ubiquitin protein ligase binding [GO:0031625]	actin filament [GO:0005884]; apical junction complex [GO:0043296]; axon [GO:0030424]; basal body patch [GO:0120220]; blood microparticle [GO:0072562]; calyx of Held [GO:0044305]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dense body [GO:0097433]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; membrane [GO:0016020]; myofibril [GO:0030016]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; profilin binding [GO:0005522]; protein kinase binding [GO:0019901]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; ubiquitin protein ligase binding [GO:0031625]; angiogenesis [GO:0001525]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; cellular response to type II interferon [GO:0071346]; maintenance of blood-brain barrier [GO:0035633]; morphogenesis of a polarized epithelium [GO:0001738]; platelet aggregation [GO:0070527]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; positive regulation of wound healing [GO:0090303]; protein localization to bicellular tight junction [GO:1902396]; regulation of focal adhesion assembly [GO:0051893]; regulation of stress fiber assembly [GO:0051492]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of transepithelial transport [GO:0150111]; retina homeostasis [GO:0001895]; sarcomere organization [GO:0045214]; tight junction assembly [GO:0120192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:28493397}.
P63267	reviewed	ACTH_HUMAN	Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form]	ACTG2 ACTA3 ACTL3 ACTSG	Homo sapiens (Human)	376	FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	MISCELLANEOUS: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.	mesenchyme migration [GO:0090131]; positive regulation of gene expression [GO:0010628]	blood microparticle [GO:0072562]; cell body [GO:0044297]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; myosin filament [GO:0032982]	ATP binding [GO:0005524]; hydrolase activity [GO:0016787]	blood microparticle [GO:0072562]; cell body [GO:0044297]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; myosin filament [GO:0032982]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; mesenchyme migration [GO:0090131]; positive regulation of gene expression [GO:0010628]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P63272	reviewed	SPT4H_HUMAN	Transcription elongation factor SPT4 (hSPT4) (DRB sensitivity-inducing factor 14 kDa subunit) (DSIF p14) (DRB sensitivity-inducing factor small subunit) (DSIF small subunit)	SUPT4H1 SPT4H SUPT4H	Homo sapiens (Human)	117	FUNCTION: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences. {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9857195}.		chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368]	DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein heterodimerization activity [GO:0046982]; RNA polymerase II complex binding [GO:0000993]; zinc ion binding [GO:0008270]	DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein heterodimerization activity [GO:0046982]; RNA polymerase II complex binding [GO:0000993]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8649394}.
P63279	reviewed	UBC9_HUMAN	SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)	UBE2I UBC9 UBCE9	Homo sapiens (Human)	158	FUNCTION: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (PubMed:26620705). {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:15809060, ECO:0000269|PubMed:17466333, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:19744555, ECO:0000269|PubMed:20077568, ECO:0000269|PubMed:26524494, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:27211601, ECO:0000269|PubMed:8668529}.		cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear membrane reassembly [GO:0007084]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear export [GO:0051168]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of SUMO transferase activity [GO:1903755]; protein modification process [GO:0036211]; protein sumoylation [GO:0016925]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; SUMO ligase complex [GO:0106068]; synaptonemal complex [GO:0000795]; transferase complex [GO:1990234]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; HLH domain binding [GO:0043398]; RING-like zinc finger domain binding [GO:0071535]; RNA binding [GO:0003723]; small protein activating enzyme binding [GO:0044388]; SUMO conjugating enzyme activity [GO:0061656]; SUMO transferase activity [GO:0019789]; transcription coregulator binding [GO:0001221]; transcription factor binding [GO:0008134]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; SUMO ligase complex [GO:0106068]; synaptonemal complex [GO:0000795]; transferase complex [GO:1990234]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; HLH domain binding [GO:0043398]; RING-like zinc finger domain binding [GO:0071535]; RNA binding [GO:0003723]; small protein activating enzyme binding [GO:0044388]; SUMO conjugating enzyme activity [GO:0061656]; SUMO transferase activity [GO:0019789]; transcription coregulator binding [GO:0001221]; transcription factor binding [GO:0008134]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear membrane reassembly [GO:0007084]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear export [GO:0051168]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of SUMO transferase activity [GO:1903755]; protein modification process [GO:0036211]; protein sumoylation [GO:0016925]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16631117, ECO:0000269|PubMed:19744555, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:27068747}. Cytoplasm {ECO:0000269|PubMed:22214662}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12573574}. Note=Mainly nuclear (By similarity). In spermatocytes, localizes in synaptonemal complexes (PubMed:8610150). Recruited by BCL11A into the nuclear body (By similarity). {ECO:0000250|UniProtKB:P63280, ECO:0000269|PubMed:8610150}.
P63316	reviewed	TNNC1_HUMAN	Troponin C, slow skeletal and cardiac muscles (TN-C)	TNNC1 TNNC	Homo sapiens (Human)	161	FUNCTION: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.	MISCELLANEOUS: Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.	cardiac muscle contraction [GO:0060048]; diaphragm contraction [GO:0002086]; regulation of ATP-dependent activity [GO:0043462]; regulation of muscle contraction [GO:0006937]; regulation of muscle filament sliding speed [GO:0032972]; response to metal ion [GO:0010038]; skeletal muscle contraction [GO:0003009]; transition between fast and slow fiber [GO:0014883]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	cardiac Troponin complex [GO:1990584]; cytosol [GO:0005829]; troponin complex [GO:0005861]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; troponin I binding [GO:0031013]; troponin T binding [GO:0031014]	cardiac Troponin complex [GO:1990584]; cytosol [GO:0005829]; troponin complex [GO:0005861]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; troponin I binding [GO:0031013]; troponin T binding [GO:0031014]; cardiac muscle contraction [GO:0060048]; diaphragm contraction [GO:0002086]; regulation of ATP-dependent activity [GO:0043462]; regulation of muscle contraction [GO:0006937]; regulation of muscle filament sliding speed [GO:0032972]; response to metal ion [GO:0010038]; skeletal muscle contraction [GO:0003009]; transition between fast and slow fiber [GO:0014883]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	
P67775	reviewed	PP2AA_HUMAN	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)	PPP2CA	Homo sapiens (Human)	309	FUNCTION: PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53 (PubMed:17245430). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9920888}.	MISCELLANEOUS: [Isoform 2]: Catalytically inactive, shows enhanced binding to IGBP1, and does not interact with the scaffolding subunit PPP2R1A. {ECO:0000305}.	apoptotic process [GO:0006915]; ceramide metabolic process [GO:0006672]; meiotic cell cycle [GO:0051321]; mesoderm development [GO:0007498]; mitotic cell cycle [GO:0000278]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of microtubule binding [GO:1904528]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of growth [GO:0040008]; regulation of microtubule binding [GO:1904526]; regulation of protein phosphorylation [GO:0001932]; regulation of Wnt signaling pathway [GO:0030111]; response to lead ion [GO:0010288]; response to organic substance [GO:0010033]; RNA splicing [GO:0008380]; second-messenger-mediated signaling [GO:0019932]; T cell homeostasis [GO:0043029]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 2A complex [GO:0000159]; spindle pole [GO:0000922]; synapse [GO:0045202]	GABA receptor binding [GO:0050811]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein heterodimerization activity [GO:0046982]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; tau protein binding [GO:0048156]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 2A complex [GO:0000159]; spindle pole [GO:0000922]; synapse [GO:0045202]; GABA receptor binding [GO:0050811]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein heterodimerization activity [GO:0046982]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; tau protein binding [GO:0048156]; apoptotic process [GO:0006915]; ceramide metabolic process [GO:0006672]; meiotic cell cycle [GO:0051321]; mesoderm development [GO:0007498]; mitotic cell cycle [GO:0000278]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of microtubule binding [GO:1904528]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of growth [GO:0040008]; regulation of microtubule binding [GO:1904526]; regulation of protein phosphorylation [GO:0001932]; regulation of Wnt signaling pathway [GO:0030111]; response to lead ion [GO:0010288]; response to organic substance [GO:0010033]; RNA splicing [GO:0008380]; second-messenger-mediated signaling [GO:0019932]; T cell homeostasis [GO:0043029]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16541025}. Nucleus {ECO:0000269|PubMed:16541025}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres (PubMed:16541025). During mitosis, also found at spindle poles (PubMed:16541025). Centromeric localization requires the presence of SGO2 (By similarity). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:16541025}.
P67809	reviewed	YBOX1_HUMAN	Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor)	YBX1 NSEP1 YB1	Homo sapiens (Human)	324	FUNCTION: DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:8188694, PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:8188694, PubMed:18809583). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}.		CRD-mediated mRNA stabilization [GO:0070934]; embryonic morphogenesis [GO:0048598]; epidermis development [GO:0008544]; miRNA transport [GO:1990428]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of cellular senescence [GO:2000773]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of translation [GO:0017148]; positive regulation of cell division [GO:0051781]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; RNA splicing [GO:0008380]; RNA transport [GO:0050658]; tRNA transport [GO:0051031]	CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; histone pre-mRNA 3'end processing complex [GO:0071204]; intracellular membrane-bounded organelle [GO:0043231]; messenger ribonucleoprotein complex [GO:1990124]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; U12-type spliceosomal complex [GO:0005689]	C5-methylcytidine-containing RNA binding [GO:0062153]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; GTPase binding [GO:0051020]; miRNA binding [GO:0035198]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]	CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; histone pre-mRNA 3'end processing complex [GO:0071204]; intracellular membrane-bounded organelle [GO:0043231]; messenger ribonucleoprotein complex [GO:1990124]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; U12-type spliceosomal complex [GO:0005689]; C5-methylcytidine-containing RNA binding [GO:0062153]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; GTPase binding [GO:0051020]; miRNA binding [GO:0035198]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; CRD-mediated mRNA stabilization [GO:0070934]; embryonic morphogenesis [GO:0048598]; epidermis development [GO:0008544]; miRNA transport [GO:1990428]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of cellular senescence [GO:2000773]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of translation [GO:0017148]; positive regulation of cell division [GO:0051781]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; RNA splicing [GO:0008380]; RNA transport [GO:0050658]; tRNA transport [GO:0051031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:15806160}. Nucleus {ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:15806160}. Cytoplasmic granule {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:25229427}. Secreted {ECO:0000269|PubMed:19483673}. Secreted, extracellular exosome {ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602}. Cytoplasm, P-body {ECO:0000250|UniProtKB:P62960}. Note=Predominantly cytoplasmic in proliferating cells (PubMed:12604611). Cytotoxic stress and DNA damage enhance translocation to the nucleus (PubMed:14718551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:25229427). Shuttles between nucleus and cytoplasm (PubMed:25229427). Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress (PubMed:18335541). Secreted by mesangial and monocytic cells after inflammatory challenges (PubMed:19483673). {ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:25229427}.
P67812	reviewed	SC11A_HUMAN	Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18)	SEC11A SEC11L1 SPC18 SPCS4A	Homo sapiens (Human)	179	FUNCTION: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (PubMed:34388369). {ECO:0000269|PubMed:34388369}.		signal peptide processing [GO:0006465]	endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; signal peptide processing [GO:0006465]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P67811}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P67811}.
P67870	reviewed	CSK2B_HUMAN	Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a)	CSNK2B CK2N G5A	Homo sapiens (Human)	215	FUNCTION: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P67871, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:16818610}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML (PubMed:20719947, PubMed:24216761). Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition (PubMed:31341047). {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761, ECO:0000269|PubMed:31341047}.		adiponectin-activated signaling pathway [GO:0033211]; disruption by symbiont of host cell PML body [GO:0075342]; endothelial tube morphogenesis [GO:0061154]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of viral life cycle [GO:1903901]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of activin receptor signaling pathway [GO:0032927]; protein-containing complex assembly [GO:0065003]; regulation of DNA binding [GO:0051101]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein kinase CK2 complex [GO:0005956]; secretory granule lumen [GO:0034774]	chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein kinase regulator activity [GO:0019887]; protein serine/threonine kinase activity [GO:0004674]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein kinase CK2 complex [GO:0005956]; secretory granule lumen [GO:0034774]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein kinase regulator activity [GO:0019887]; protein serine/threonine kinase activity [GO:0004674]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]; adiponectin-activated signaling pathway [GO:0033211]; disruption by symbiont of host cell PML body [GO:0075342]; endothelial tube morphogenesis [GO:0061154]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of viral life cycle [GO:1903901]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of activin receptor signaling pathway [GO:0032927]; protein-containing complex assembly [GO:0065003]; regulation of DNA binding [GO:0051101]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31341047}.
P67936	reviewed	TPM4_HUMAN	Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)	TPM4	Homo sapiens (Human)	248	FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). {ECO:0000250|UniProtKB:P09495, ECO:0000269|PubMed:1836432}.		actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; osteoblast differentiation [GO:0001649]	actin filament [GO:0005884]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; muscle thin filament tropomyosin [GO:0005862]; podosome [GO:0002102]; stress fiber [GO:0001725]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307]	actin filament [GO:0005884]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; muscle thin filament tropomyosin [GO:0005862]; podosome [GO:0002102]; stress fiber [GO:0001725]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307]; actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; osteoblast differentiation [GO:0001649]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P09495}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P09495}.
P68032	reviewed	ACTC_HUMAN	Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]	ACTC1 ACTC	Homo sapiens (Human)	377	FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	MISCELLANEOUS: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.	actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; actin-myosin filament sliding [GO:0033275]; actomyosin structure organization [GO:0031032]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; heart contraction [GO:0060047]; mesenchyme migration [GO:0090131]; negative regulation of apoptotic process [GO:0043066]; positive regulation of gene expression [GO:0010628]; skeletal muscle thin filament assembly [GO:0030240]	actin filament [GO:0005884]; blood microparticle [GO:0072562]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; I band [GO:0031674]; lamellipodium [GO:0030027]; membrane [GO:0016020]; sarcomere [GO:0030017]	ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; microfilament motor activity [GO:0000146]; myosin binding [GO:0017022]	actin filament [GO:0005884]; blood microparticle [GO:0072562]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; I band [GO:0031674]; lamellipodium [GO:0030027]; membrane [GO:0016020]; sarcomere [GO:0030017]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; microfilament motor activity [GO:0000146]; myosin binding [GO:0017022]; actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; actin-myosin filament sliding [GO:0033275]; actomyosin structure organization [GO:0031032]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; heart contraction [GO:0060047]; mesenchyme migration [GO:0090131]; negative regulation of apoptotic process [GO:0043066]; positive regulation of gene expression [GO:0010628]; skeletal muscle thin filament assembly [GO:0030240]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P68036	reviewed	UB2L3_HUMAN	Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)	UBE2L3 UBCE7 UBCH7	Homo sapiens (Human)	154	FUNCTION: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN, RNF31 and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:15367689, ECO:0000269|PubMed:17003263, ECO:0000269|PubMed:18946090, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:35294289}.		cell cycle phase transition [GO:0044770]; cell population proliferation [GO:0008283]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to steroid hormone stimulus [GO:0071383]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein K11-linked ubiquitination [GO:0070979]; protein modification process [GO:0036211]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA-templated transcription [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activator activity [GO:0097027]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activator activity [GO:0097027]; ubiquitin-protein transferase activity [GO:0004842]; cell cycle phase transition [GO:0044770]; cell population proliferation [GO:0008283]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to steroid hormone stimulus [GO:0071383]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein K11-linked ubiquitination [GO:0070979]; protein modification process [GO:0036211]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA-templated transcription [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11278816, ECO:0000269|PubMed:17003263}. Cytoplasm {ECO:0000269|PubMed:11278816, ECO:0000269|PubMed:17003263}.
P68104	reviewed	EF1A1_HUMAN	Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7)	EEF1A1 EEF1A EF1A LENG7	Homo sapiens (Human)	462	FUNCTION: Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26651998, PubMed:26593721, PubMed:36264623, PubMed:36123449, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26651998, PubMed:26593721, PubMed:36264623, PubMed:36123449, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26651998, PubMed:26593721, PubMed:36264623, PubMed:36123449). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). {ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}.		cellular response to epidermal growth factor stimulus [GO:0071364]; positive regulation by host of viral genome replication [GO:0044829]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of D-erythro-sphingosine kinase activity [GO:1900022]; translation [GO:0006412]; translational elongation [GO:0006414]	cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; eukaryotic translation elongation factor 1 complex [GO:0005853]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribosome [GO:0005840]; ruffle membrane [GO:0032587]; secretory granule lumen [GO:0034774]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049]	cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; eukaryotic translation elongation factor 1 complex [GO:0005853]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribosome [GO:0005840]; ruffle membrane [GO:0032587]; secretory granule lumen [GO:0034774]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049]; cellular response to epidermal growth factor stimulus [GO:0071364]; positive regulation by host of viral genome replication [GO:0044829]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of D-erythro-sphingosine kinase activity [GO:1900022]; translation [GO:0006412]; translational elongation [GO:0006414]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19158340, ECO:0000269|PubMed:8650580}. Nucleus {ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:8650580}. Nucleus, nucleolus {ECO:0000269|PubMed:8650580}. Cell membrane {ECO:0000269|PubMed:26497934}. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery (PubMed:19158340). Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens (PubMed:8650580). Localization at the cell membrane depends on EEF1A1 phosphorylation status and the presence of PPP1R16B (PubMed:26497934). {ECO:0000269|PubMed:19158340, ECO:0000269|PubMed:26497934, ECO:0000269|PubMed:8650580}.
P68106	reviewed	FKB1B_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B) (EC 5.2.1.8) (12.6 kDa FK506-binding protein) (12.6 kDa FKBP) (FKBP-12.6) (FK506-binding protein 1B) (FKBP-1B) (Immunophilin FKBP12.6) (Rotamase) (h-FKBP-12)	FKBP1B FKBP12.6 FKBP1L FKBP9 OTK4	Homo sapiens (Human)	108	FUNCTION: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000269|PubMed:7513996, ECO:0000269|PubMed:7592869}.		'de novo' protein folding [GO:0006458]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; negative regulation of heart rate [GO:0010459]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neuronal action potential propagation [GO:0019227]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of sequestering of calcium ion [GO:0051284]; protein maturation by protein folding [GO:0022417]; protein peptidyl-prolyl isomerization [GO:0000413]; protein refolding [GO:0042026]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hydrogen peroxide [GO:0042542]; response to redox state [GO:0051775]; response to vitamin E [GO:0033197]; smooth muscle contraction [GO:0006939]; T cell proliferation [GO:0042098]	calcium channel complex [GO:0034704]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018]	calcium channel inhibitor activity [GO:0019855]; cyclic nucleotide binding [GO:0030551]; FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]	calcium channel complex [GO:0034704]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018]; calcium channel inhibitor activity [GO:0019855]; cyclic nucleotide binding [GO:0030551]; FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; 'de novo' protein folding [GO:0006458]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; negative regulation of heart rate [GO:0010459]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neuronal action potential propagation [GO:0019227]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of sequestering of calcium ion [GO:0051284]; protein maturation by protein folding [GO:0022417]; protein peptidyl-prolyl isomerization [GO:0000413]; protein refolding [GO:0042026]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hydrogen peroxide [GO:0042542]; response to redox state [GO:0051775]; response to vitamin E [GO:0033197]; smooth muscle contraction [GO:0006939]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}.
P68133	reviewed	ACTS_HUMAN	Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]	ACTA1 ACTA	Homo sapiens (Human)	377	FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	MISCELLANEOUS: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.	cellular response to organonitrogen compound [GO:0071417]; mesenchyme migration [GO:0090131]; muscle contraction [GO:0006936]; positive regulation of gene expression [GO:0010628]; response to extracellular stimulus [GO:0009991]; response to mechanical stimulus [GO:0009612]; response to steroid hormone [GO:0048545]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle fiber development [GO:0048741]; skeletal muscle thin filament assembly [GO:0030240]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; blood microparticle [GO:0072562]; cell body [GO:0044297]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; striated muscle thin filament [GO:0005865]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; myosin binding [GO:0017022]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; blood microparticle [GO:0072562]; cell body [GO:0044297]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; striated muscle thin filament [GO:0005865]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; myosin binding [GO:0017022]; structural constituent of cytoskeleton [GO:0005200]; cellular response to organonitrogen compound [GO:0071417]; mesenchyme migration [GO:0090131]; muscle contraction [GO:0006936]; positive regulation of gene expression [GO:0010628]; response to extracellular stimulus [GO:0009991]; response to mechanical stimulus [GO:0009612]; response to steroid hormone [GO:0048545]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle fiber development [GO:0048741]; skeletal muscle thin filament assembly [GO:0030240]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P68363	reviewed	TBA1B_HUMAN	Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain]	TUBA1B	Homo sapiens (Human)	451	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:34996871). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871). {ECO:0000269|PubMed:34996871}.		cell division [GO:0051301]; cellular response to interleukin-4 [GO:0071353]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]	double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625]; cell division [GO:0051301]; cellular response to interleukin-4 [GO:0071353]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:35482892}.
P68366	reviewed	TBA4A_HUMAN	Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain)	TUBA4A TUBA1	Homo sapiens (Human)	448	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P68371	reviewed	TBB4B_HUMAN	Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain)	TUBB4B TUBB2C	Homo sapiens (Human)	445	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267]	axonemal microtubule [GO:0005879]; azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]	double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; MHC class I protein binding [GO:0042288]; structural constituent of cytoskeleton [GO:0005200]; unfolded protein binding [GO:0051082]	axonemal microtubule [GO:0005879]; azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; MHC class I protein binding [GO:0042288]; structural constituent of cytoskeleton [GO:0005200]; unfolded protein binding [GO:0051082]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P68400	reviewed	CSK21_HUMAN	Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)	CSNK2A1 CK2A1	Homo sapiens (Human)	391	FUNCTION: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621, PubMed:24962073, PubMed:31439799). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387552, PubMed:19387551). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387552, PubMed:19387551). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis (PubMed:11239457). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064). Phosphorylates YY1, protecting YY1 from cleavage by CASP7 during apoptosis (PubMed:22184066). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551, PubMed:23123191). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551, PubMed:23123191). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621). Plays an important role in the circadian clock function by phosphorylating BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). Phosphorylates FMR1, promoting FMR1-dependent formation of a membraneless compartment (PubMed:30765518, PubMed:31439799). {ECO:0000250|UniProtKB:P19139, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:19188443, ECO:0000269|PubMed:20625391, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22406621, ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:24962073, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:31439799, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}.	MISCELLANEOUS: Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome. Casein kinase 2 has been found to be increased at protein level and up-regulated at the level of enzyme activity in the majority of cancers. However, elevated levels of casein kinase 2 are present in certain normal organs such as brain and testes.	apoptotic process [GO:0006915]; cell cycle [GO:0007049]; chaperone-mediated protein folding [GO:0061077]; disruption by symbiont of host cell PML body [GO:0075342]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of translation [GO:0017148]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of chromosome separation [GO:1905818]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; protein kinase CK2 complex [GO:0005956]; Sin3 complex [GO:0016580]	ATP binding [GO:0005524]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; protein kinase CK2 complex [GO:0005956]; Sin3 complex [GO:0016580]; ATP binding [GO:0005524]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; chaperone-mediated protein folding [GO:0061077]; disruption by symbiont of host cell PML body [GO:0075342]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of translation [GO:0017148]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of chromosome separation [GO:1905818]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:24962073}.
P68402	reviewed	PA1B2_HUMAN	Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta)	PAFAH1B2 PAFAHB	Homo sapiens (Human)	229	FUNCTION: Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity). {ECO:0000250|UniProtKB:P68401, ECO:0000250|UniProtKB:Q61206}.	MISCELLANEOUS: Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (PubMed:9144386) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity). {ECO:0000250|UniProtKB:P43034, ECO:0000250|UniProtKB:Q15102, ECO:0000250|UniProtKB:Q29460, ECO:0000303|PubMed:9144386}.	lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; positive regulation of macroautophagy [GO:0016239]; spermatogenesis [GO:0007283]	1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; ficolin-1-rich granule lumen [GO:1904813]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; platelet-activating factor acetyltransferase activity [GO:0047179]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; ficolin-1-rich granule lumen [GO:1904813]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; platelet-activating factor acetyltransferase activity [GO:0047179]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; positive regulation of macroautophagy [GO:0016239]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm.
P68431	reviewed	H31_HUMAN	Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	Homo sapiens (Human)	136	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	MISCELLANEOUS: This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).	chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029]; gene expression [GO:0010467]; nucleosome assembly [GO:0006334]; telomere organization [GO:0032200]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	cadherin binding [GO:0045296]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; cadherin binding [GO:0045296]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029]; gene expression [GO:0010467]; nucleosome assembly [GO:0006334]; telomere organization [GO:0032200]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P68871	reviewed	HBB_HUMAN	Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]	HBB	Homo sapiens (Human)	147	FUNCTION: Involved in oxygen transport from the lung to the various peripheral tissues. {ECO:0000269|PubMed:28066926}.; FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; FUNCTION: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.	MISCELLANEOUS: One molecule of 2,3-bisphosphoglycerate can bind to two beta chains per hemoglobin tetramer.	blood vessel diameter maintenance [GO:0097746]; carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; nitric oxide transport [GO:0030185]; oxygen transport [GO:0015671]; platelet aggregation [GO:0070527]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of blood pressure [GO:0008217]; renal absorption [GO:0070293]; response to hydrogen peroxide [GO:0042542]	blood microparticle [GO:0072562]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; tertiary granule lumen [GO:1904724]	heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; hemoglobin binding [GO:0030492]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]	blood microparticle [GO:0072562]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; tertiary granule lumen [GO:1904724]; heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; hemoglobin binding [GO:0030492]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; blood vessel diameter maintenance [GO:0097746]; carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; nitric oxide transport [GO:0030185]; oxygen transport [GO:0015671]; platelet aggregation [GO:0070527]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of blood pressure [GO:0008217]; renal absorption [GO:0070293]; response to hydrogen peroxide [GO:0042542]	
P69849	reviewed	NOMO3_HUMAN	BOS complex subunit NOMO3 (Nodal modulator 3) (pM5 protein 3)	NOMO3	Homo sapiens (Human)	1222	FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261522, PubMed:32820719). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). {ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.		multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; negative regulation of nodal signaling pathway [GO:1900108]	endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]	carbohydrate binding [GO:0030246]; ribosome binding [GO:0043022]	endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]; carbohydrate binding [GO:0030246]; ribosome binding [GO:0043022]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; negative regulation of nodal signaling pathway [GO:1900108]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17261586, ECO:0000269|PubMed:36261522}; Single-pass type I membrane protein {ECO:0000255}.
P69891	reviewed	HBG1_HUMAN	Hemoglobin subunit gamma-1 (Gamma-1-globin) (Hb F Agamma) (Hemoglobin gamma-1 chain) (Hemoglobin gamma-A chain)	HBG1 PRO2979	Homo sapiens (Human)	147	FUNCTION: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. {ECO:0000269|PubMed:11514664, ECO:0000269|PubMed:22096240, ECO:0000269|PubMed:6198905}.		carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]	cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]	heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]	cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]	
P69892	reviewed	HBG2_HUMAN	Hemoglobin subunit gamma-2 (Gamma-2-globin) (Hb F Ggamma) (Hemoglobin gamma-2 chain) (Hemoglobin gamma-G chain)	HBG2	Homo sapiens (Human)	147	FUNCTION: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. {ECO:0000269|PubMed:19065339, ECO:0000269|PubMed:21561349, ECO:0000269|PubMed:24502349}.		carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]	blood microparticle [GO:0072562]; cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]	heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]	blood microparticle [GO:0072562]; cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]	
P69905	reviewed	HBA_HUMAN	Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin]	HBA1; HBA2	Homo sapiens (Human)	142	FUNCTION: Involved in oxygen transport from the lung to the various peripheral tissues.; FUNCTION: [Hemopressin]: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1 (PubMed:18077343). Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling (PubMed:18077343). {ECO:0000269|PubMed:18077343}.	MISCELLANEOUS: Gives blood its red color.	carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; nitric oxide transport [GO:0030185]; oxygen transport [GO:0015671]; response to hydrogen peroxide [GO:0042542]	blood microparticle [GO:0072562]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; membrane [GO:0016020]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]	blood microparticle [GO:0072562]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; membrane [GO:0016020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; nitric oxide transport [GO:0030185]; oxygen transport [GO:0015671]; response to hydrogen peroxide [GO:0042542]	
P78310	reviewed	CXAR_HUMAN	Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR)	CXADR CAR	Homo sapiens (Human)	365	FUNCTION: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}.		actin cytoskeleton organization [GO:0030036]; AV node cell to bundle of His cell communication [GO:0086067]; AV node cell-bundle of His cell adhesion involved in cell communication [GO:0086072]; cardiac muscle cell development [GO:0055013]; cell-cell junction organization [GO:0045216]; defense response to virus [GO:0051607]; epithelial structure maintenance [GO:0010669]; gamma-delta T cell activation [GO:0046629]; germ cell migration [GO:0008354]; heart development [GO:0007507]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homotypic cell-cell adhesion [GO:0034109]; mitochondrion organization [GO:0007005]; neutrophil chemotaxis [GO:0030593]; regulation of AV node cell action potential [GO:0098904]; transepithelial transport [GO:0070633]	acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell body [GO:0044297]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercalated disc [GO:0014704]; membrane raft [GO:0045121]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	beta-catenin binding [GO:0008013]; cell adhesion molecule binding [GO:0050839]; cell adhesive protein binding involved in AV node cell-bundle of His cell communication [GO:0086082]; connexin binding [GO:0071253]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618]	acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell body [GO:0044297]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercalated disc [GO:0014704]; membrane raft [GO:0045121]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; beta-catenin binding [GO:0008013]; cell adhesion molecule binding [GO:0050839]; cell adhesive protein binding involved in AV node cell-bundle of His cell communication [GO:0086082]; connexin binding [GO:0071253]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618]; actin cytoskeleton organization [GO:0030036]; AV node cell to bundle of His cell communication [GO:0086067]; AV node cell-bundle of His cell adhesion involved in cell communication [GO:0086072]; cardiac muscle cell development [GO:0055013]; cell-cell junction organization [GO:0045216]; defense response to virus [GO:0051607]; epithelial structure maintenance [GO:0010669]; gamma-delta T cell activation [GO:0046629]; germ cell migration [GO:0008354]; heart development [GO:0007507]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homotypic cell-cell adhesion [GO:0034109]; mitochondrion organization [GO:0007005]; neutrophil chemotaxis [GO:0030593]; regulation of AV node cell action potential [GO:0098904]; transepithelial transport [GO:0070633]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15533241}; Single-pass type I membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:11316797, ECO:0000269|PubMed:12021372, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15364909}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051}. Cell junction, adherens junction {ECO:0000269|PubMed:12297051}. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797). {ECO:0000269|PubMed:11316797, ECO:0000269|PubMed:12297051}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:14978041}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000269|PubMed:14978041}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000269|PubMed:14978041}.
P78314	reviewed	3BP2_HUMAN	SH3 domain-binding protein 2 (3BP-2)	SH3BP2 3BP2 RES4-23	Homo sapiens (Human)	561	FUNCTION: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	signal transduction [GO:0007165]		phosphotyrosine residue binding [GO:0001784]; SH3 domain binding [GO:0017124]	phosphotyrosine residue binding [GO:0001784]; SH3 domain binding [GO:0017124]; signal transduction [GO:0007165]	
P78316	reviewed	NOP14_HUMAN	Nucleolar protein 14 (Nucleolar complex protein 14)	NOP14 C4orf9 NOL14 RES4-25	Homo sapiens (Human)	857	FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}.		endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	90S preribosome [GO:0030686]; membrane [GO:0016020]; Noc4p-Nop14p complex [GO:0030692]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	enzyme binding [GO:0019899]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]	90S preribosome [GO:0030686]; membrane [GO:0016020]; Noc4p-Nop14p complex [GO:0030692]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; enzyme binding [GO:0019899]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
P78317	reviewed	RNF4_HUMAN	E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF)	RNF4 SNURF RES4-26	Homo sapiens (Human)	190	FUNCTION: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:18408734, PubMed:19307308, PubMed:35013556). Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:18408734, PubMed:19307308, PubMed:20943951). Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (PubMed:20212317). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (PubMed:19779455, PubMed:20026589). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:12885770). Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (PubMed:35013556). {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:19779455, ECO:0000269|PubMed:20026589, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20943951, ECO:0000269|PubMed:35013556}.		negative regulation of protein localization to chromatin [GO:0120186]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; regulation of kinetochore assembly [GO:0090234]; regulation of spindle assembly [GO:0090169]; response to arsenic-containing substance [GO:0046685]	cytoplasm [GO:0005737]; microtubule end [GO:1990752]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; nuclear receptor coactivator activity [GO:0030374]; nucleosome binding [GO:0031491]; SUMO polymer binding [GO:0032184]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; microtubule end [GO:1990752]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; nuclear receptor coactivator activity [GO:0030374]; nucleosome binding [GO:0031491]; SUMO polymer binding [GO:0032184]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; negative regulation of protein localization to chromatin [GO:0120186]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; regulation of kinetochore assembly [GO:0090234]; regulation of spindle assembly [GO:0090169]; response to arsenic-containing substance [GO:0046685]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12885770}. Nucleus {ECO:0000269|PubMed:12885770}. Nucleus, PML body {ECO:0000269|PubMed:15707587, ECO:0000269|PubMed:20943951}.
P78318	reviewed	IGBP1_HUMAN	Immunoglobulin-binding protein 1 (B-cell signal transduction molecule alpha 4) (Protein alpha-4) (CD79a-binding protein 1) (Protein phosphatase 2/4/6 regulatory subunit) (Renal carcinoma antigen NY-REN-16)	IGBP1 IBP1	Homo sapiens (Human)	339	FUNCTION: Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. {ECO:0000269|PubMed:19818709, ECO:0000269|PubMed:23591866}.		B cell activation [GO:0042113]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of dephosphorylation [GO:0035303]; regulation of microtubule-based movement [GO:0060632]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888]; B cell activation [GO:0042113]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of dephosphorylation [GO:0035303]; regulation of microtubule-based movement [GO:0060632]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P78324	reviewed	SHPS1_HUMAN	Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)	SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP	Homo sapiens (Human)	504	FUNCTION: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity). Receptor for THBS1 (PubMed:24511121). Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (PubMed:24511121). {ECO:0000250, ECO:0000250|UniProtKB:P97710, ECO:0000269|PubMed:10469599, ECO:0000269|PubMed:11509594, ECO:0000269|PubMed:24511121}.		cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-12 [GO:0071349]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; monocyte extravasation [GO:0035696]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of I-kappaB phosphorylation [GO:1903720]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of JNK cascade [GO:0046329]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870]; regulation of gene expression [GO:0010468]; regulation of interleukin-1 beta production [GO:0032651]; regulation of interleukin-6 production [GO:0032675]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of tumor necrosis factor production [GO:0032680]; regulation of type II interferon production [GO:0032649]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	cell-cell adhesion mediator activity [GO:0098632]; GTPase regulator activity [GO:0030695]; protein antigen binding [GO:1990405]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; SH3 domain binding [GO:0017124]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; cell-cell adhesion mediator activity [GO:0098632]; GTPase regulator activity [GO:0030695]; protein antigen binding [GO:1990405]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; SH3 domain binding [GO:0017124]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-12 [GO:0071349]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; monocyte extravasation [GO:0035696]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of I-kappaB phosphorylation [GO:1903720]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of JNK cascade [GO:0046329]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870]; regulation of gene expression [GO:0010468]; regulation of interleukin-1 beta production [GO:0032651]; regulation of interleukin-6 production [GO:0032675]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of tumor necrosis factor production [GO:0032680]; regulation of type II interferon production [GO:0032649]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P78325	reviewed	ADAM8_HUMAN	Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a)	ADAM8 MS2	Homo sapiens (Human)	824	FUNCTION: Possible involvement in extravasation of leukocytes.		angiogenesis [GO:0001525]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cellular response to hypoxia [GO:0071456]; extracellular matrix disassembly [GO:0022617]; inflammatory response [GO:0006954]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte chemotaxis [GO:0048247]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of eosinophil migration [GO:2000418]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibronectin-dependent thymocyte migration [GO:2000415]; positive regulation of innate immune response [GO:0045089]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein processing [GO:0010954]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of transforming growth factor beta1 activation [GO:1901394]; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000309]; proteolysis [GO:0006508]; regulation of cell-cell adhesion [GO:0022407]	alpha9-beta1 integrin-ADAM8 complex [GO:0071133]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dense core granule membrane [GO:0032127]; ficolin-1-rich granule membrane [GO:0101003]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]; podosome [GO:0002102]; specific granule [GO:0042581]; specific granule membrane [GO:0035579]; tertiary granule [GO:0070820]; tertiary granule membrane [GO:0070821]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; protein self-association [GO:0043621]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	alpha9-beta1 integrin-ADAM8 complex [GO:0071133]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dense core granule membrane [GO:0032127]; ficolin-1-rich granule membrane [GO:0101003]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]; podosome [GO:0002102]; specific granule [GO:0042581]; specific granule membrane [GO:0035579]; tertiary granule [GO:0070820]; tertiary granule membrane [GO:0070821]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; protein self-association [GO:0043621]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; angiogenesis [GO:0001525]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cellular response to hypoxia [GO:0071456]; extracellular matrix disassembly [GO:0022617]; inflammatory response [GO:0006954]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte chemotaxis [GO:0048247]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of eosinophil migration [GO:2000418]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibronectin-dependent thymocyte migration [GO:2000415]; positive regulation of innate immune response [GO:0045089]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein processing [GO:0010954]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of transforming growth factor beta1 activation [GO:1901394]; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000309]; proteolysis [GO:0006508]; regulation of cell-cell adhesion [GO:0022407]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P78329	reviewed	CP4F2_HUMAN	Cytochrome P450 4F2 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450-LTB-omega) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.14.94) (Phylloquinone omega-hydroxylase CYP4F2) (EC 1.14.14.78)	CYP4F2	Homo sapiens (Human)	520	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins (PubMed:18577768, PubMed:10833273, PubMed:10660572, PubMed:11997390, PubMed:17341693, PubMed:18574070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs) (PubMed:18577768). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10660572, PubMed:17341693, PubMed:18574070). Plays a role in the oxidative inactivation of eicosanoids, including both pro-inflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:8026587, PubMed:9799565, PubMed:10833273, PubMed:10660572, PubMed:17341693, PubMed:18574070, PubMed:18577768). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids (PubMed:18065749). Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites (PubMed:15145985). Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening (PubMed:16547005, PubMed:18182499). Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues (PubMed:11997390). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:19297519, PubMed:24138531). {ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:10833273, ECO:0000269|PubMed:11997390, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:16547005, ECO:0000269|PubMed:17341693, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:18574070, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:24138531, ECO:0000269|PubMed:8026587, ECO:0000269|PubMed:9799565}.		arachidonic acid metabolic process [GO:0019369]; blood coagulation [GO:0007596]; epoxygenase P450 pathway [GO:0019373]; fatty acid omega-oxidation [GO:0010430]; icosanoid metabolic process [GO:0006690]; leukotriene B4 catabolic process [GO:0036101]; leukotriene metabolic process [GO:0006691]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; negative regulation of icosanoid secretion [GO:0032304]; omega-hydroxylase P450 pathway [GO:0097267]; phylloquinone catabolic process [GO:0042376]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; regulation of blood pressure [GO:0008217]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; vitamin K catabolic process [GO:0042377]; xenobiotic metabolic process [GO:0006805]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259]; 20-hydroxy-leukotriene B4 omega oxidase activity [GO:0097258]; alkane 1-monooxygenase activity [GO:0018685]; alpha-tocopherol omega-hydroxylase activity [GO:0052871]; arachidonic acid epoxygenase activity [GO:0008392]; arachidonic acid omega-hydroxylase activity [GO:0052869]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; tocotrienol omega-hydroxylase activity [GO:0052872]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; 20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259]; 20-hydroxy-leukotriene B4 omega oxidase activity [GO:0097258]; alkane 1-monooxygenase activity [GO:0018685]; alpha-tocopherol omega-hydroxylase activity [GO:0052871]; arachidonic acid epoxygenase activity [GO:0008392]; arachidonic acid omega-hydroxylase activity [GO:0052869]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; tocotrienol omega-hydroxylase activity [GO:0052872]; arachidonic acid metabolic process [GO:0019369]; blood coagulation [GO:0007596]; epoxygenase P450 pathway [GO:0019373]; fatty acid omega-oxidation [GO:0010430]; icosanoid metabolic process [GO:0006690]; leukotriene B4 catabolic process [GO:0036101]; leukotriene metabolic process [GO:0006691]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; negative regulation of icosanoid secretion [GO:0032304]; omega-hydroxylase P450 pathway [GO:0097267]; phylloquinone catabolic process [GO:0042376]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; regulation of blood pressure [GO:0008217]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; vitamin K catabolic process [GO:0042377]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:24138531, ECO:0000269|PubMed:8026587}; Peripheral membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20861217}; Peripheral membrane protein {ECO:0000305}.
P78330	reviewed	SERB_HUMAN	Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (L-3-phosphoserine phosphatase) (O-phosphoserine phosphohydrolase)	PSPH	Homo sapiens (Human)	225	FUNCTION: Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine (PubMed:12213811, PubMed:15291819, PubMed:9222972, PubMed:14673469, PubMed:25080166). L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator (PubMed:14673469). May also act on O-phospho-D-serine (Probable). {ECO:0000269|PubMed:12213811, ECO:0000269|PubMed:14673469, ECO:0000269|PubMed:15291819, ECO:0000269|PubMed:25080166, ECO:0000269|PubMed:9222972, ECO:0000303|PubMed:14673469, ECO:0000305|PubMed:1965857}.		dephosphorylation [GO:0016311]; in utero embryonic development [GO:0001701]; L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; response to testosterone [GO:0033574]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	identical protein binding [GO:0042802]; L-phosphoserine phosphatase activity [GO:0036424]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; L-phosphoserine phosphatase activity [GO:0036424]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; dephosphorylation [GO:0016311]; in utero embryonic development [GO:0001701]; L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; response to testosterone [GO:0033574]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:1965857}.
P78332	reviewed	RBM6_HUMAN	RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3)	RBM6 DEF3	Homo sapiens (Human)	1123	FUNCTION: Specifically binds poly(G) RNA homopolymers in vitro.		mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]	nucleus [GO:0005634]	DNA binding [GO:0003677]; RNA binding [GO:0003723]	nucleus [GO:0005634]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P78333	reviewed	GPC5_HUMAN	Glypican-5 [Cleaved into: Secreted glypican-5]	GPC5	Homo sapiens (Human)	572	FUNCTION: Cell surface proteoglycan that bears heparan sulfate. {ECO:0000250}.		cell migration [GO:0016477]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of protein localization to membrane [GO:1905475]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell migration [GO:0016477]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of protein localization to membrane [GO:1905475]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.; SUBCELLULAR LOCATION: [Secreted glypican-5]: Secreted, extracellular space {ECO:0000250}.
P78334	reviewed	GBRE_HUMAN	Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon)	GABRE	Homo sapiens (Human)	506	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.		chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of chloride transport [GO:2001226]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]	chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of chloride transport [GO:2001226]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
P78337	reviewed	PITX1_HUMAN	Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1)	PITX1 BFT PTX1	Homo sapiens (Human)	314	FUNCTION: Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. {ECO:0000250|UniProtKB:P56673}.		anatomical structure morphogenesis [GO:0009653]; branchiomeric skeletal muscle development [GO:0014707]; cartilage development [GO:0051216]; embryonic hindlimb morphogenesis [GO:0035116]; myoblast fate commitment [GO:0048625]; negative regulation of DNA-templated transcription [GO:0045892]; pituitary gland development [GO:0021983]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; branchiomeric skeletal muscle development [GO:0014707]; cartilage development [GO:0051216]; embryonic hindlimb morphogenesis [GO:0035116]; myoblast fate commitment [GO:0048625]; negative regulation of DNA-templated transcription [GO:0045892]; pituitary gland development [GO:0021983]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Nucleus.
P78344	reviewed	IF4G2_HUMAN	Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97)	EIF4G2 DAP5 OK/SW-cl.75	Homo sapiens (Human)	907	FUNCTION: Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}.	MISCELLANEOUS: This gene has been shown to be extensively edited in the liver of APOBEC1 transgenic animal model. Its aberrant editing could contribute to the potent oncogenesis induced by overexpression of APOBEC1. The aberrant edited sequence, called NAT1, is likely to be a fundamental translational repressor.	cell death [GO:0008219]; heart development [GO:0007507]; macromolecule biosynthetic process [GO:0009059]; negative regulation of autophagy [GO:0010507]; positive regulation of axon extension [GO:0045773]; positive regulation of cell growth [GO:0030307]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of translation [GO:0045727]; regulation of cell cycle [GO:0051726]; regulation of translational initiation [GO:0006446]	adherens junction [GO:0005912]; axon [GO:0030424]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]	cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	adherens junction [GO:0005912]; axon [GO:0030424]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; cell death [GO:0008219]; heart development [GO:0007507]; macromolecule biosynthetic process [GO:0009059]; negative regulation of autophagy [GO:0010507]; positive regulation of axon extension [GO:0045773]; positive regulation of cell growth [GO:0030307]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of translation [GO:0045727]; regulation of cell cycle [GO:0051726]; regulation of translational initiation [GO:0006446]	
P78345	reviewed	RPP38_HUMAN	Ribonuclease P protein subunit p38 (RNaseP protein p38)	RPP38	Homo sapiens (Human)	283	FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9037013, PubMed:9630247, PubMed:10444065, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:10444065, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247}.	MISCELLANEOUS: Autoantibodies against RPP38 are found in sera from scleroderma patients.	rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]	fibrillar center [GO:0001650]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]	ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]	fibrillar center [GO:0001650]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]; ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10444065}.
P78346	reviewed	RPP30_HUMAN	Ribonuclease P protein subunit p30 (RNaseP protein p30) (RNase P subunit 2)	RPP30 RNASEP2	Homo sapiens (Human)	268	FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9037013, PubMed:9630247, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247}.	MISCELLANEOUS: Autoantibodies against RPP30 are found in sera from scleroderma patients.	rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]; tRNA processing [GO:0008033]	multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]	ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723]	multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]; ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723]; rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]; tRNA processing [GO:0008033]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305}.
P78347	reviewed	GTF2I_HUMAN	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein)	GTF2I BAP135 WBSCR6	Homo sapiens (Human)	998	FUNCTION: Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}.		negative regulation of angiogenesis [GO:0016525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; negative regulation of angiogenesis [GO:0016525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10373551}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00484, ECO:0000269|PubMed:10373551}. Note=Colocalizes with BTK in the cytoplasm.
P78348	reviewed	ASIC1_HUMAN	Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2)	ASIC1 ACCN2 BNAC2	Homo sapiens (Human)	528	FUNCTION: Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. {ECO:0000269|PubMed:22760635}.; FUNCTION: Isoform 1 does not display proton-gated cation channel activity. {ECO:0000269|PubMed:22760635}.	MISCELLANEOUS: Potentiated by Ca(2+), Mg(2+), Ba(2+) and multivalent cations. Inhibited by anti-inflammatory drugs like salicylic acid (By similarity). Potentiated by FMRFamide-related neuropeptides. PH dependence may be regulated by serine proteases. {ECO:0000250}.	associative learning [GO:0008306]; behavioral fear response [GO:0001662]; calcium ion transmembrane transport [GO:0070588]; cellular response to pH [GO:0071467]; memory [GO:0007613]; negative regulation of neurotransmitter secretion [GO:0046929]; neurotransmitter secretion [GO:0007269]; protein homotrimerization [GO:0070207]; regulation of membrane potential [GO:0042391]; response to acidic pH [GO:0010447]; response to amphetamine [GO:0001975]; response to pH [GO:0009268]; sensory perception of sour taste [GO:0050915]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	acid-sensing ion channel activity [GO:0044736]; ligand-gated sodium channel activity [GO:0015280]	cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; acid-sensing ion channel activity [GO:0044736]; ligand-gated sodium channel activity [GO:0015280]; associative learning [GO:0008306]; behavioral fear response [GO:0001662]; calcium ion transmembrane transport [GO:0070588]; cellular response to pH [GO:0071467]; memory [GO:0007613]; negative regulation of neurotransmitter secretion [GO:0046929]; neurotransmitter secretion [GO:0007269]; protein homotrimerization [GO:0070207]; regulation of membrane potential [GO:0042391]; response to acidic pH [GO:0010447]; response to amphetamine [GO:0001975]; response to pH [GO:0009268]; sensory perception of sour taste [GO:0050915]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12578970, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:22760635}; Multi-pass membrane protein {ECO:0000269|PubMed:12578970, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:22760635}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). {ECO:0000250}.
P78352	reviewed	DLG4_HUMAN	Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)	DLG4 PSD95	Homo sapiens (Human)	724	FUNCTION: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}.		AMPA glutamate receptor clustering [GO:0097113]; cell-cell adhesion [GO:0098609]; cellular response to potassium ion [GO:0035865]; chemical synaptic transmission [GO:0007268]; dendritic spine morphogenesis [GO:0060997]; establishment of protein localization [GO:0045184]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; learning [GO:0007612]; locomotory exploration behavior [GO:0035641]; negative regulation of receptor internalization [GO:0002091]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of synaptic transmission [GO:0050806]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; protein localization to synapse [GO:0035418]; protein-containing complex assembly [GO:0065003]; receptor localization to synapse [GO:0097120]; regulation of grooming behavior [GO:2000821]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of NMDA receptor activity [GO:2000310]; signal transduction [GO:0007165]; social behavior [GO:0035176]; synaptic vesicle maturation [GO:0016188]; vocalization behavior [GO:0071625]	adherens junction [GO:0005912]; AMPA glutamate receptor complex [GO:0032281]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cerebellar mossy fiber [GO:0044300]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; excitatory synapse [GO:0060076]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]	acetylcholine receptor binding [GO:0033130]; beta-1 adrenergic receptor binding [GO:0031697]; D1 dopamine receptor binding [GO:0031748]; ionotropic glutamate receptor binding [GO:0035255]; kinase binding [GO:0019900]; neuroligin family protein binding [GO:0097109]; P2Y1 nucleotide receptor binding [GO:0031812]; PDZ domain binding [GO:0030165]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]	adherens junction [GO:0005912]; AMPA glutamate receptor complex [GO:0032281]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cerebellar mossy fiber [GO:0044300]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; excitatory synapse [GO:0060076]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; acetylcholine receptor binding [GO:0033130]; beta-1 adrenergic receptor binding [GO:0031697]; D1 dopamine receptor binding [GO:0031748]; ionotropic glutamate receptor binding [GO:0035255]; kinase binding [GO:0019900]; neuroligin family protein binding [GO:0097109]; P2Y1 nucleotide receptor binding [GO:0031812]; PDZ domain binding [GO:0030165]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; AMPA glutamate receptor clustering [GO:0097113]; cell-cell adhesion [GO:0098609]; cellular response to potassium ion [GO:0035865]; chemical synaptic transmission [GO:0007268]; dendritic spine morphogenesis [GO:0060997]; establishment of protein localization [GO:0045184]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; learning [GO:0007612]; locomotory exploration behavior [GO:0035641]; negative regulation of receptor internalization [GO:0002091]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of synaptic transmission [GO:0050806]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; protein localization to synapse [GO:0035418]; protein-containing complex assembly [GO:0065003]; receptor localization to synapse [GO:0097120]; regulation of grooming behavior [GO:2000821]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of NMDA receptor activity [GO:2000310]; signal transduction [GO:0007165]; social behavior [GO:0035176]; synaptic vesicle maturation [GO:0016188]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12151521}; Lipid-anchor {ECO:0000269|PubMed:12151521}; Cytoplasmic side {ECO:0000269|PubMed:12151521}. Postsynaptic density {ECO:0000250|UniProtKB:P31016}. Synapse {ECO:0000269|PubMed:12151521}. Cytoplasm {ECO:0000250|UniProtKB:P31016}. Cell projection, axon {ECO:0000250|UniProtKB:P31016}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P31016}. Cell projection, dendrite {ECO:0000250|UniProtKB:P31016}. Presynapse {ECO:0000250|UniProtKB:P31016}. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4. {ECO:0000250|UniProtKB:P31016}.
P78356	reviewed	PI42B_HUMAN	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)	PIP4K2B PIP5K2B	Homo sapiens (Human)	416	FUNCTION: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:9038203, PubMed:26774281). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9038203}.		1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; autophagosome-lysosome fusion [GO:0061909]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; protein homodimerization activity [GO:0042803]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; protein homodimerization activity [GO:0042803]; 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; autophagosome-lysosome fusion [GO:0061909]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20583997}. Cytoplasm {ECO:0000269|PubMed:20583997}. Note=Associated with the plasma membrane and the endoplasmic reticulum. {ECO:0000250}.
P78357	reviewed	CNTP1_HUMAN	Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (p190)	CNTNAP1 CASPR NRXN4	Homo sapiens (Human)	1384	FUNCTION: Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. {ECO:0000269|PubMed:24319099, ECO:0000269|PubMed:27818385, ECO:0000269|PubMed:28374019}.		axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; central nervous system myelination [GO:0022010]; cytoskeleton organization [GO:0007010]; mitochondrion organization [GO:0007005]; myelination in peripheral nervous system [GO:0022011]; neuromuscular junction development, skeletal muscle fiber [GO:0098529]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; neuron projection morphogenesis [GO:0048812]; neuronal action potential propagation [GO:0019227]; paranodal junction assembly [GO:0030913]; paranodal junction maintenance [GO:1990227]; postsynaptic density organization [GO:0097106]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; regulation of synapse maturation [GO:0090128]; signal transduction [GO:0007165]	glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]	SH3 domain binding [GO:0017124]; signaling receptor activity [GO:0038023]	glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; SH3 domain binding [GO:0017124]; signaling receptor activity [GO:0038023]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; central nervous system myelination [GO:0022010]; cytoskeleton organization [GO:0007010]; mitochondrion organization [GO:0007005]; myelination in peripheral nervous system [GO:0022011]; neuromuscular junction development, skeletal muscle fiber [GO:0098529]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; neuron projection morphogenesis [GO:0048812]; neuronal action potential propagation [GO:0019227]; paranodal junction assembly [GO:0030913]; paranodal junction maintenance [GO:1990227]; postsynaptic density organization [GO:0097106]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; regulation of synapse maturation [GO:0090128]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, paranodal septate junction {ECO:0000250|UniProtKB:O54991}.
P78358	reviewed	CTG1B_HUMAN	Cancer/testis antigen 1 (Autoimmunogenic cancer/testis antigen NY-ESO-1) (Cancer/testis antigen 6.1) (CT6.1) (L antigen family member 2) (LAGE-2)	CTAG1A CTAG CTAG1 ESO1 LAGE2 LAGE2A; CTAG1B LAGE2B	Homo sapiens (Human)	180			tRNA threonylcarbamoyladenosine metabolic process [GO:0070525]	cytoplasm [GO:0005737]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; tRNA threonylcarbamoyladenosine metabolic process [GO:0070525]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12065688}.
P78362	reviewed	SRPK2_HUMAN	SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]	SRPK2	Homo sapiens (Human)	688	FUNCTION: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:9472028, PubMed:18559500, PubMed:21056976). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}.		angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of viral genome replication [GO:0045071]; nuclear speck organization [GO:0035063]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; R-loop processing [GO:0062176]; regulation of mRNA processing [GO:0050684]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of viral genome replication [GO:0045071]; nuclear speck organization [GO:0035063]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; R-loop processing [GO:0062176]; regulation of mRNA processing [GO:0050684]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21157427, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21157427, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. Nucleus speckle {ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. Chromosome {ECO:0000269|PubMed:28076779}. Note=Shuttles between the nucleus and the cytoplasm (PubMed:19592491, PubMed:21157427, PubMed:21056976). KAT5/TIP60 inhibits its nuclear translocation (PubMed:21157427). Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation (PubMed:19592491). Preferentially localizes across the entire gene coding region (PubMed:28076779). During transcription, accumulates at chromatin loci where unscheduled R-loops form and colocalizes with paused 'Ser-5'-phosphorlyated POLR2A/RNA polymerase II and helicase DDX23 (PubMed:28076779). {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21157427, ECO:0000269|PubMed:28076779}.
P78363	reviewed	ABCA4_HUMAN	Retinal-specific phospholipid-transporting ATPase ABCA4 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM proteinv) (RmP) (Retinal-specific ATP-binding cassette transporter) (Stargardt disease protein)	ABCA4 ABCR	Homo sapiens (Human)	2273	FUNCTION: Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like the 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where N-cis-retinylidene-phosphatidylethanolamine (N-cis-R-PE) is then isomerized to its all-trans isomer (N-trans-R-PE) and reduced by RDH8 to produce all-trans-retinol (all-trans-rol) and therefore prevents the accumulation of excess of 11-cis-retinal and its schiff-base conjugate and the formation of toxic bisretinoid (PubMed:24097981, PubMed:22735453, PubMed:23144455, PubMed:20404325, PubMed:10075733, PubMed:29847635, PubMed:33375396). May display both ATPase and GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds (PubMed:22735453). Binds the unprotonated form of N-retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP, and ATP binding and hydrolysis induce a protein conformational change that causes the dissociation of N-retinylidene-phosphatidylethanolamine (By similarity). {ECO:0000250|UniProtKB:F1MWM0, ECO:0000269|PubMed:10075733, ECO:0000269|PubMed:20404325, ECO:0000269|PubMed:22735453, ECO:0000269|PubMed:23144455, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:29847635, ECO:0000269|PubMed:33375396}.		lipid transport [GO:0006869]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; photoreceptor cell maintenance [GO:0045494]; phototransduction, visible light [GO:0007603]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; transmembrane transport [GO:0055085]; visual perception [GO:0007601]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; rod photoreceptor disc membrane [GO:0120202]	11-cis retinal binding [GO:0005502]; ABC-type transporter activity [GO:0140359]; all-trans retinal binding [GO:0005503]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; flippase activity [GO:0140327]; GTPase activity [GO:0003924]; N-retinylidene-phosphatidylethanolamine flippase activity [GO:0140347]; phosphatidylethanolamine flippase activity [GO:0090555]; phospholipid transporter activity [GO:0005548]; retinoid binding [GO:0005501]; retinol transmembrane transporter activity [GO:0034632]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; rod photoreceptor disc membrane [GO:0120202]; 11-cis retinal binding [GO:0005502]; ABC-type transporter activity [GO:0140359]; all-trans retinal binding [GO:0005503]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; flippase activity [GO:0140327]; GTPase activity [GO:0003924]; N-retinylidene-phosphatidylethanolamine flippase activity [GO:0140347]; phosphatidylethanolamine flippase activity [GO:0090555]; phospholipid transporter activity [GO:0005548]; retinoid binding [GO:0005501]; retinol transmembrane transporter activity [GO:0034632]; lipid transport [GO:0006869]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; photoreceptor cell maintenance [GO:0045494]; phototransduction, visible light [GO:0007603]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; transmembrane transport [GO:0055085]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10075733}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:24097981}. Cytoplasmic vesicle {ECO:0000269|PubMed:29847635, ECO:0000269|PubMed:33375396}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:F1MWM0}. Note=Localized to the rim and incisures of rod outer segments disks. {ECO:0000250|UniProtKB:F1MWM0}.
P78364	reviewed	PHC1_HUMAN	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)	PHC1 EDR1 PH1	Homo sapiens (Human)	1004	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression. {ECO:0000269|PubMed:23418308}.	MISCELLANEOUS: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.	cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; zinc ion binding [GO:0008270]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; zinc ion binding [GO:0008270]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530, ECO:0000269|PubMed:9121482}.
P78367	reviewed	NKX32_HUMAN	Homeobox protein Nkx-3.2 (Bagpipe homeobox protein homolog 1) (Homeobox protein NK-3 homolog B)	NKX3-2 BAPX1 NKX3B	Homo sapiens (Human)	333	FUNCTION: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). {ECO:0000250}.		animal organ formation [GO:0048645]; cell differentiation [GO:0030154]; determination of left/right symmetry [GO:0007368]; embryonic skeletal system development [GO:0048706]; intestinal epithelial cell development [GO:0060576]; middle ear morphogenesis [GO:0042474]; negative regulation of apoptotic process [GO:0043066]; negative regulation of chondrocyte differentiation [GO:0032331]; pancreas development [GO:0031016]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; spleen development [GO:0048536]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ formation [GO:0048645]; cell differentiation [GO:0030154]; determination of left/right symmetry [GO:0007368]; embryonic skeletal system development [GO:0048706]; intestinal epithelial cell development [GO:0060576]; middle ear morphogenesis [GO:0042474]; negative regulation of apoptotic process [GO:0043066]; negative regulation of chondrocyte differentiation [GO:0032331]; pancreas development [GO:0031016]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; spleen development [GO:0048536]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P78368	reviewed	KC1G2_HUMAN	Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1)	CSNK1G2 CK1G2	Homo sapiens (Human)	415	FUNCTION: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (PubMed:15077195, PubMed:15917222, PubMed:18794808, PubMed:19005213). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (PubMed:37099597). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:Q8BVP5, ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18794808, ECO:0000269|PubMed:19005213, ECO:0000269|PubMed:37099597}.		endocytosis [GO:0006897]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148]; Wnt signaling pathway [GO:0016055]	cell cortex [GO:0005938]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell cortex [GO:0005938]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; endocytosis [GO:0006897]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:26481050}. Cytoplasm {ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:26481050}.
P78369	reviewed	CLD10_HUMAN	Claudin-10 (Oligodendrocyte-specific protein-like) (OSP-like)	CLDN10	Homo sapiens (Human)	228	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28771254, PubMed:28686597). {ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:28771254}.	MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 2. {ECO:0000305}.	bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269]	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:19383724}. Cell membrane {ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:28771254}; Multi-pass membrane protein {ECO:0000255}.
P78371	reviewed	TCPB_HUMAN	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta)	CCT2 99D8.1 CCTB	Homo sapiens (Human)	535	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.		binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666]	azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microtubule [GO:0005874]; zona pellucida receptor complex [GO:0002199]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microtubule [GO:0005874]; zona pellucida receptor complex [GO:0002199]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20080638}.
P78380	reviewed	OLR1_HUMAN	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form]	OLR1 CLEC8A LOX1	Homo sapiens (Human)	273	FUNCTION: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. {ECO:0000269|PubMed:11821063, ECO:0000269|PubMed:12354387, ECO:0000269|PubMed:9052782}.; FUNCTION: (Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis. {ECO:0000305|PubMed:27302108}.		blood circulation [GO:0008015]; immune system process [GO:0002376]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; lipoprotein metabolic process [GO:0042157]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor activity [GO:0005041]	extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor activity [GO:0005041]; blood circulation [GO:0008015]; immune system process [GO:0002376]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; lipoprotein metabolic process [GO:0042157]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation.
P78381	reviewed	S35A2_HUMAN	UDP-galactose translocator (Solute carrier family 35 member A2) (UDP-galactose transporter) (UDP-Gal-Tr) (UGT)	SLC35A2 UGALT UGT UGTL	Homo sapiens (Human)	396	FUNCTION: Transports uridine diphosphate galactose (UDP-galactose) from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges UDP-galactose for UMP (PubMed:9010752, PubMed:12682060). It is also able to exchange UDP-galactose for AMP and CMP, and to transport UDP-N-acetylgalactosamine (UDP-GalNAc) and other nucleotide sugars (PubMed:12682060, PubMed:11784306). As a provider of UDP-galactose to galactosyltransferases present in the Golgi apparatus, it is necessary for globotriaosylceramide/globoside (Gb3Cer) synthesis from lactosylceramide (PubMed:30817854). {ECO:0000269|PubMed:11784306, ECO:0000269|PubMed:12682060, ECO:0000269|PubMed:23561849, ECO:0000269|PubMed:30817854, ECO:0000269|PubMed:30834435, ECO:0000269|PubMed:9010752}.		carbohydrate transport [GO:0008643]; galactose metabolic process [GO:0006012]; UDP-galactose transmembrane transport [GO:0072334]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]	antiporter activity [GO:0015297]; UDP-galactose transmembrane transporter activity [GO:0005459]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; antiporter activity [GO:0015297]; UDP-galactose transmembrane transporter activity [GO:0005459]; carbohydrate transport [GO:0008643]; galactose metabolic process [GO:0006012]; UDP-galactose transmembrane transport [GO:0072334]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15932921}. Golgi apparatus membrane {ECO:0000269|PubMed:15932921, ECO:0000269|PubMed:24115232, ECO:0000269|PubMed:28167211}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane {ECO:0000269|PubMed:15932921}.
P78382	reviewed	S35A1_HUMAN	CMP-sialic acid transporter (CMP-SA-Tr) (CMP-Sia-Tr) (CST) (Solute carrier family 35 member A1)	SLC35A1	Homo sapiens (Human)	337	FUNCTION: Transports CMP-sialic acid from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges CMP-sialic acid for CMP (PubMed:15576474, PubMed:12682060, PubMed:23873973). Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (By similarity). Also able to exchange CMP-sialic acid for AMP and UMP (PubMed:12682060). Also mediates the transport of CDP-ribitol (By similarity). {ECO:0000250|UniProtKB:Q61420, ECO:0000269|PubMed:12682060, ECO:0000269|PubMed:15576474, ECO:0000269|PubMed:23873973}.		carbohydrate metabolic process [GO:0005975]; carbohydrate transport [GO:0008643]; CMP-N-acetylneuraminate transmembrane transport [GO:0015782]; protein modification process [GO:0036211]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	antiporter activity [GO:0015297]; CMP-N-acetylneuraminate transmembrane transporter activity [GO:0005456]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; CMP-N-acetylneuraminate transmembrane transporter activity [GO:0005456]; carbohydrate metabolic process [GO:0005975]; carbohydrate transport [GO:0008643]; CMP-N-acetylneuraminate transmembrane transport [GO:0015782]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q61420}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q61420}. Golgi apparatus {ECO:0000269|PubMed:23873973}.
P78383	reviewed	S35B1_HUMAN	Solute carrier family 35 member B1 (ATP/ADP exchanger ER) (AXER) (Endoplasmic reticulum ATP/ADP translocase) (UDP-galactose transporter-related protein 1) (UGTrel1)	SLC35B1 UGTREL1	Homo sapiens (Human)	322	FUNCTION: ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction (PubMed:30154480, PubMed:35041824). Regulates ER energy metabolism and protein biogenesis. Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply. Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER (PubMed:30154480, PubMed:35041824). Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established (PubMed:30154480, PubMed:35041824). {ECO:0000269|PubMed:30154480, ECO:0000269|PubMed:35041824}.; FUNCTION: [Isoform 1]: ATP:ADP antiporter. {ECO:0000269|PubMed:30154480, ECO:0000269|PubMed:35041824}.; FUNCTION: [Isoform 2]: ATP:ADP antiporter. {ECO:0000269|PubMed:30154480}.		UDP-galactose transmembrane transport [GO:0072334]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	ATP:ADP antiporter activity [GO:0005471]; UDP-galactose transmembrane transporter activity [GO:0005459]; UDP-glucose transmembrane transporter activity [GO:0005460]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; ATP:ADP antiporter activity [GO:0005471]; UDP-galactose transmembrane transporter activity [GO:0005459]; UDP-glucose transmembrane transporter activity [GO:0005460]; UDP-galactose transmembrane transport [GO:0072334]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30154480}; Multi-pass membrane protein {ECO:0000255}.
P78385	reviewed	KRT83_HUMAN	Keratin, type II cuticular Hb3 (Hair keratin K2.10) (Keratin-83) (K83) (Type II hair keratin Hb3) (Type-II keratin Kb23)	KRT83 KRTHB3	Homo sapiens (Human)	493		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	epidermis development [GO:0008544]; hair cycle [GO:0042633]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; extracellular space [GO:0005615]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular space [GO:0005615]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; epidermis development [GO:0008544]; hair cycle [GO:0042633]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
P78386	reviewed	KRT85_HUMAN	Keratin, type II cuticular Hb5 (Hair keratin K2.12) (Keratin-85) (K85) (Type II hair keratin Hb5) (Type-II keratin Kb25)	KRT85 KRTHB5	Homo sapiens (Human)	507		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; extracellular space [GO:0005615]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]; structural molecule activity [GO:0005198]	cytosol [GO:0005829]; extracellular space [GO:0005615]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; structural molecule activity [GO:0005198]; epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
P78395	reviewed	PRAME_HUMAN	Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma)	PRAME MAPE OIP4	Homo sapiens (Human)	509	FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:21822215, PubMed:26138980). The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation (PubMed:21822215). Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis (PubMed:16179254). {ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:26138980}.	MISCELLANEOUS: Tumor antigen recognized by cytolytic T lymphocytes. {ECO:0000269|PubMed:9047241}.	apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]	chromatin [GO:0000785]; Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	nuclear retinoic acid receptor binding [GO:0042974]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	chromatin [GO:0000785]; Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; nuclear retinoic acid receptor binding [GO:0042974]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:23460923, ECO:0000305|PubMed:16620968}. Chromosome {ECO:0000269|PubMed:21822215}. Cytoplasm {ECO:0000269|PubMed:23460923}. Golgi apparatus {ECO:0000269|PubMed:23460923}. Cell membrane {ECO:0000269|PubMed:16620968}. Note=Associates with chromatin; specifically enriched at transcriptionally active promoters that are also bound by nuclear transcription factor Y (composed of NFYA, NFYB and NFYC) and at enhancers (PubMed:21822215). Recruited to the Golgi apparatus in response to interferon gamma (IFNG) treatment (PubMed:23460923). {ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:23460923}.
P78396	reviewed	CCNA1_HUMAN	Cyclin-A1	CCNA1	Homo sapiens (Human)	465	FUNCTION: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. {ECO:0000269|PubMed:10022926}.		cell division [GO:0051301]; male meiosis I [GO:0007141]; mitotic cell cycle phase transition [GO:0044772]; spermatogenesis [GO:0007283]	cyclin A1-CDK2 complex [GO:0097123]; cyclin A2-CDK2 complex [GO:0097124]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin A1-CDK2 complex [GO:0097123]; cyclin A2-CDK2 complex [GO:0097124]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; cell division [GO:0051301]; male meiosis I [GO:0007141]; mitotic cell cycle phase transition [GO:0044772]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P78406	reviewed	RAE1L_HUMAN	mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41)	RAE1 MRNP41	Homo sapiens (Human)	368	FUNCTION: Acts as mRNA export factor involved in nucleocytoplasmic transport (PubMed:33849972, PubMed:20498086). Plays a role in mitotic bipolar spindle formation (PubMed:17172455). May function in attaching cytoplasmic mRNPs to the cytoskeleton both directly or indirectly (PubMed:17172455). {ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:20498086, ECO:0000269|PubMed:33849972}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to organic cyclic compound [GO:0071407]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; regulation of mitotic spindle organization [GO:0060236]; RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; mitotic spindle pole [GO:0097431]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	microtubule binding [GO:0008017]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; mitotic spindle pole [GO:0097431]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to organic cyclic compound [GO:0071407]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; regulation of mitotic spindle organization [GO:0060236]; RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9256445}. Nucleus {ECO:0000269|PubMed:9256445}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:17172455}. Nucleus envelope {ECO:0000269|PubMed:33360543}. Note=Recruited from interphase nuclei to spindle MTs during mitosis. {ECO:0000269|PubMed:17172455}.
P78410	reviewed	BT3A2_HUMAN	Butyrophilin subfamily 3 member A2	BTN3A2 BT3.2 BTF3 BTF4	Homo sapiens (Human)	334	FUNCTION: Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells. {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}.		positive regulation of type II interferon production [GO:0032729]; regulation of cytokine production [GO:0001817]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor binding [GO:0005102]; positive regulation of type II interferon production [GO:0032729]; regulation of cytokine production [GO:0001817]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}; Single-pass type I membrane protein {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}.
P78411	reviewed	IRX5_HUMAN	Iroquois-class homeodomain protein IRX-5 (Homeodomain protein IRX-2A) (Homeodomain protein IRXB2) (Iroquois homeobox protein 5)	IRX5 IRX2A IRXB2	Homo sapiens (Human)	483	FUNCTION: Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. {ECO:0000250, ECO:0000269|PubMed:22581230}.		cell development [GO:0048468]; embryonic cranial skeleton morphogenesis [GO:0048701]; gonad development [GO:0008406]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; vitamin D binding [GO:0005499]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; vitamin D binding [GO:0005499]; cell development [GO:0048468]; embryonic cranial skeleton morphogenesis [GO:0048701]; gonad development [GO:0008406]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P78412	reviewed	IRX6_HUMAN	Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6)	IRX6 IRX7 IRXB3	Homo sapiens (Human)	446	FUNCTION: Transcription factor. Binds to the iroquois binding site (IBS) motif of target genes to regulate gene expression; functions as a transcriptional activator or repressor. Modulates expression of RCVRN, VSX1, BHLHE22/BHLHB5 and TACR3/Nk3r. Required downstream of retinal bipolar cell specification for the terminal differentiation of type 2, type 3a and possibly type 6 bipolar cells. {ECO:0000250|UniProtKB:Q9ER75}.		cell development [GO:0048468]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell development [GO:0048468]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P78413	reviewed	IRX4_HUMAN	Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4)	IRX4 IRXA3	Homo sapiens (Human)	519	FUNCTION: Likely to be an important mediator of ventricular differentiation during cardiac development.		cell development [GO:0048468]; establishment of animal organ orientation [GO:0048561]; heart development [GO:0007507]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell development [GO:0048468]; establishment of animal organ orientation [GO:0048561]; heart development [GO:0007507]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P78415	reviewed	IRX3_HUMAN	Iroquois-class homeodomain protein IRX-3 (Homeodomain protein IRXB1) (Iroquois homeobox protein 3)	IRX3 IRXB1	Homo sapiens (Human)	501	FUNCTION: Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. {ECO:0000250|UniProtKB:P81067}.		atrioventricular bundle cell differentiation [GO:0003167]; cell development [GO:0048468]; energy homeostasis [GO:0097009]; His-Purkinje system cell differentiation [GO:0060932]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Purkinje myocyte development [GO:0003165]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of loop of Henle identity [GO:0072086]	axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; atrioventricular bundle cell differentiation [GO:0003167]; cell development [GO:0048468]; energy homeostasis [GO:0097009]; His-Purkinje system cell differentiation [GO:0060932]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Purkinje myocyte development [GO:0003165]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of loop of Henle identity [GO:0072086]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P78417	reviewed	GSTO1_HUMAN	Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R)	GSTO1 GSTTLP28	Homo sapiens (Human)	241	FUNCTION: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. {ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863, ECO:0000269|PubMed:21106529}.		cellular response to arsenic-containing substance [GO:0071243]; glutathione metabolic process [GO:0006749]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014810]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; xenobiotic catabolic process [GO:0042178]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	glutathione dehydrogenase (ascorbate) activity [GO:0045174]; glutathione transferase activity [GO:0004364]; methylarsonate reductase activity [GO:0050610]; oxidoreductase activity [GO:0016491]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutathione dehydrogenase (ascorbate) activity [GO:0045174]; glutathione transferase activity [GO:0004364]; methylarsonate reductase activity [GO:0050610]; oxidoreductase activity [GO:0016491]; cellular response to arsenic-containing substance [GO:0071243]; glutathione metabolic process [GO:0006749]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014810]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; xenobiotic catabolic process [GO:0042178]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11511179}.
P78423	reviewed	X3CL1_HUMAN	Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]	CX3CL1 FKN NTT SCYD1 A-152E5.2	Homo sapiens (Human)	397	FUNCTION: Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1 (PubMed:9782118, PubMed:12055230, PubMed:23125415, PubMed:9931005, PubMed:21829356). The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:9024663, PubMed:9177350, PubMed:9782118, PubMed:12055230). Regulates leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350). Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner (PubMed:23125415, PubMed:24789099). In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins (PubMed:23125415, PubMed:24789099). In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). {ECO:0000269|PubMed:12055230, ECO:0000269|PubMed:21829356, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:9024663, ECO:0000269|PubMed:9177350, ECO:0000269|PubMed:9782118, ECO:0000269|PubMed:9931005}.; FUNCTION: [Processed fractalkine]: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. {ECO:0000269|PubMed:9024663}.; FUNCTION: [Fractalkine]: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. {ECO:0000269|PubMed:9024663}.; FUNCTION: (Microbial infection) Mediates the cytoadherence of erythrocytes infected with parasite P.falciparum (strain 3D7) with endothelial cells by interacting with P.falciparum CBP1 and CBP2 expressed at the surface of erythrocytes (PubMed:27653778). The adhesion prevents the elimination of infected erythrocytes by the spleen (Probable). {ECO:0000269|PubMed:27653778, ECO:0000305|PubMed:27653778}.		angiogenesis involved in wound healing [GO:0060055]; autocrine signaling [GO:0035425]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eosinophil chemotaxis [GO:0048245]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin activation [GO:0033622]; leukocyte adhesive activation [GO:0050902]; leukocyte chemotaxis [GO:0030595]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte chemotaxis [GO:0048247]; microglial cell activation [GO:0001774]; microglial cell proliferation [GO:0061518]; monocyte chemotaxis [GO:0002548]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of glutamate receptor signaling pathway [GO:1900450]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neuron migration [GO:2001223]; negative regulation of tumor necrosis factor production [GO:0032720]; neuron cellular homeostasis [GO:0070050]; neuron remodeling [GO:0016322]; neutrophil chemotaxis [GO:0030593]; positive chemotaxis [GO:0050918]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of calcium-independent cell-cell adhesion [GO:0051041]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of inflammatory response [GO:0050729]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of neurogenesis [GO:0050767]; regulation of synaptic plasticity [GO:0048167]; response to ischemia [GO:0002931]; synapse pruning [GO:0098883]	cell projection [GO:0042995]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	CCR chemokine receptor binding [GO:0048020]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; CX3C chemokine receptor binding [GO:0031737]; CXCR1 chemokine receptor binding [GO:0045237]; integrin binding [GO:0005178]; signaling receptor binding [GO:0005102]	cell projection [GO:0042995]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; CCR chemokine receptor binding [GO:0048020]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; CX3C chemokine receptor binding [GO:0031737]; CXCR1 chemokine receptor binding [GO:0045237]; integrin binding [GO:0005178]; signaling receptor binding [GO:0005102]; angiogenesis involved in wound healing [GO:0060055]; autocrine signaling [GO:0035425]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eosinophil chemotaxis [GO:0048245]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin activation [GO:0033622]; leukocyte adhesive activation [GO:0050902]; leukocyte chemotaxis [GO:0030595]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte chemotaxis [GO:0048247]; microglial cell activation [GO:0001774]; microglial cell proliferation [GO:0061518]; monocyte chemotaxis [GO:0002548]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of glutamate receptor signaling pathway [GO:1900450]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neuron migration [GO:2001223]; negative regulation of tumor necrosis factor production [GO:0032720]; neuron cellular homeostasis [GO:0070050]; neuron remodeling [GO:0016322]; neutrophil chemotaxis [GO:0030593]; positive chemotaxis [GO:0050918]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of calcium-independent cell-cell adhesion [GO:0051041]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of inflammatory response [GO:0050729]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of neurogenesis [GO:0050767]; regulation of synaptic plasticity [GO:0048167]; response to ischemia [GO:0002931]; synapse pruning [GO:0098883]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9024663}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Processed fractalkine]: Secreted {ECO:0000269|PubMed:9024663}.
P78424	reviewed	PO6F2_HUMAN	POU domain, class 6, transcription factor 2 (Retina-derived POU domain factor 1) (RPF-1)	POU6F2 RPF1	Homo sapiens (Human)	691	FUNCTION: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.	MISCELLANEOUS: [Isoform 1]: Major isoform.	central nervous system development [GO:0007417]; ganglion mother cell fate determination [GO:0007402]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; central nervous system development [GO:0007417]; ganglion mother cell fate determination [GO:0007402]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P78426	reviewed	NKX61_HUMAN	Homeobox protein Nkx-6.1 (Homeobox protein NK-6 homolog A)	NKX6-1 NKX6A	Homo sapiens (Human)	367	FUNCTION: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q99MA9}.		animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cellular response to cytokine stimulus [GO:0071345]; cellular response to peptide hormone stimulus [GO:0071375]; central nervous system neuron differentiation [GO:0021953]; glucose mediated signaling pathway [GO:0010255]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oligodendrocyte differentiation [GO:0048709]; pancreas development [GO:0031016]; pancreatic A cell differentiation [GO:0003310]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of insulin secretion [GO:0032024]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell development [GO:2000078]; regulation of axon extension [GO:0030516]; regulation of neuron migration [GO:2001222]; regulation of transcription by RNA polymerase II [GO:0006357]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell maturation [GO:0072560]; type B pancreatic cell proliferation [GO:0044342]	chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cellular response to cytokine stimulus [GO:0071345]; cellular response to peptide hormone stimulus [GO:0071375]; central nervous system neuron differentiation [GO:0021953]; glucose mediated signaling pathway [GO:0010255]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oligodendrocyte differentiation [GO:0048709]; pancreas development [GO:0031016]; pancreatic A cell differentiation [GO:0003310]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of insulin secretion [GO:0032024]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell development [GO:2000078]; regulation of axon extension [GO:0030516]; regulation of neuron migration [GO:2001222]; regulation of transcription by RNA polymerase II [GO:0006357]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell maturation [GO:0072560]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P78504	reviewed	JAG1_HUMAN	Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)	JAG1 JAGL1	Homo sapiens (Human)	1218	FUNCTION: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). {ECO:0000250, ECO:0000269|PubMed:18660822, ECO:0000269|PubMed:20437614, ECO:0000269|PubMed:9462510}.		angiogenesis [GO:0001525]; aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; blood vessel remodeling [GO:0001974]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cell fate determination [GO:0001709]; ciliary body morphogenesis [GO:0061073]; distal tubule development [GO:0072017]; endocardial cushion cell development [GO:0061444]; endothelial cell differentiation [GO:0045446]; hemopoiesis [GO:0030097]; inhibition of neuroepithelial cell differentiation [GO:0002085]; inner ear auditory receptor cell differentiation [GO:0042491]; keratinocyte differentiation [GO:0030216]; loop of Henle development [GO:0072070]; morphogenesis of an epithelial sheet [GO:0002011]; myoblast differentiation [GO:0045445]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of stem cell differentiation [GO:2000737]; nephron development [GO:0072006]; nervous system development [GO:0007399]; neuroendocrine cell differentiation [GO:0061101]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; podocyte development [GO:0072015]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of cell population proliferation [GO:0042127]; regulation of epithelial cell proliferation [GO:0050678]; regulation of reproductive process [GO:2000241]; response to muramyl dipeptide [GO:0032495]; T cell mediated immunity [GO:0002456]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; molecular adaptor activity [GO:0060090]; Notch binding [GO:0005112]; phospholipid binding [GO:0005543]; structural molecule activity [GO:0005198]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; molecular adaptor activity [GO:0060090]; Notch binding [GO:0005112]; phospholipid binding [GO:0005543]; structural molecule activity [GO:0005198]; angiogenesis [GO:0001525]; aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; blood vessel remodeling [GO:0001974]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cell fate determination [GO:0001709]; ciliary body morphogenesis [GO:0061073]; distal tubule development [GO:0072017]; endocardial cushion cell development [GO:0061444]; endothelial cell differentiation [GO:0045446]; hemopoiesis [GO:0030097]; inhibition of neuroepithelial cell differentiation [GO:0002085]; inner ear auditory receptor cell differentiation [GO:0042491]; keratinocyte differentiation [GO:0030216]; loop of Henle development [GO:0072070]; morphogenesis of an epithelial sheet [GO:0002011]; myoblast differentiation [GO:0045445]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of stem cell differentiation [GO:2000737]; nephron development [GO:0072006]; nervous system development [GO:0007399]; neuroendocrine cell differentiation [GO:0061101]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; podocyte development [GO:0072015]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of cell population proliferation [GO:0042127]; regulation of epithelial cell proliferation [GO:0050678]; regulation of reproductive process [GO:2000241]; response to muramyl dipeptide [GO:0032495]; T cell mediated immunity [GO:0002456]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000269|PubMed:32065591}.
P78508	reviewed	KCJ10_HUMAN	ATP-sensitive inward rectifier potassium channel 10 (ATP-dependent inwardly rectifying potassium channel Kir4.1) (Inward rectifier K(+) channel Kir1.2) (Potassium channel, inwardly rectifying subfamily J member 10)	KCNJ10	Homo sapiens (Human)	379	FUNCTION: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules. {ECO:0000250, ECO:0000305|PubMed:24561201}.		adult walking behavior [GO:0007628]; cellular response to potassium ion [GO:0035865]; central nervous system myelination [GO:0022010]; glutamate reuptake [GO:0051935]; non-motile cilium assembly [GO:1905515]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of resting membrane potential [GO:0060075]; visual perception [GO:0007601]	astrocyte projection [GO:0097449]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; ciliary base [GO:0097546]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; inward rectifier potassium channel activity [GO:0005242]	astrocyte projection [GO:0097449]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; ciliary base [GO:0097546]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; inward rectifier potassium channel activity [GO:0005242]; adult walking behavior [GO:0007628]; cellular response to potassium ion [GO:0035865]; central nervous system myelination [GO:0022010]; glutamate reuptake [GO:0051935]; non-motile cilium assembly [GO:1905515]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of resting membrane potential [GO:0060075]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24561201}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:24561201}. Note=In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16. {ECO:0000269|PubMed:24561201}.
P78509	reviewed	RELN_HUMAN	Reelin (EC 3.4.21.-)	RELN	Homo sapiens (Human)	3460	FUNCTION: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity). {ECO:0000250}.		associative learning [GO:0008306]; axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell morphogenesis involved in differentiation [GO:0000904]; central nervous system development [GO:0007417]; cerebral cortex tangential migration [GO:0021800]; dendrite development [GO:0016358]; glial cell differentiation [GO:0010001]; hippocampus development [GO:0021766]; interneuron migration [GO:1904936]; lateral motor column neuron migration [GO:0097477]; layer formation in cerebral cortex [GO:0021819]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; modulation of chemical synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; NMDA glutamate receptor clustering [GO:0097114]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of AMPA receptor activity [GO:2000969]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of lateral motor column neuron migration [GO:1902078]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of TOR signaling [GO:0032008]; postsynaptic density protein 95 clustering [GO:0097119]; protein localization to synapse [GO:0035418]; proteolysis [GO:0006508]; receptor localization to synapse [GO:0097120]; reelin-mediated signaling pathway [GO:0038026]; regulation of behavior [GO:0050795]; regulation of neuron differentiation [GO:0045664]; regulation of neuron migration [GO:2001222]; regulation of NMDA receptor activity [GO:2000310]; regulation of synaptic activity [GO:0060025]; response to pain [GO:0048265]; spinal cord patterning [GO:0021511]; ventral spinal cord development [GO:0021517]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; reelin complex [GO:0110157]	lipoprotein particle receptor binding [GO:0070325]; metal ion binding [GO:0046872]; serine-type peptidase activity [GO:0008236]; very-low-density lipoprotein particle receptor binding [GO:0070326]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; reelin complex [GO:0110157]; lipoprotein particle receptor binding [GO:0070325]; metal ion binding [GO:0046872]; serine-type peptidase activity [GO:0008236]; very-low-density lipoprotein particle receptor binding [GO:0070326]; associative learning [GO:0008306]; axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell morphogenesis involved in differentiation [GO:0000904]; central nervous system development [GO:0007417]; cerebral cortex tangential migration [GO:0021800]; dendrite development [GO:0016358]; glial cell differentiation [GO:0010001]; hippocampus development [GO:0021766]; interneuron migration [GO:1904936]; lateral motor column neuron migration [GO:0097477]; layer formation in cerebral cortex [GO:0021819]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; modulation of chemical synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; NMDA glutamate receptor clustering [GO:0097114]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of AMPA receptor activity [GO:2000969]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of lateral motor column neuron migration [GO:1902078]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of TOR signaling [GO:0032008]; postsynaptic density protein 95 clustering [GO:0097119]; protein localization to synapse [GO:0035418]; proteolysis [GO:0006508]; receptor localization to synapse [GO:0097120]; reelin-mediated signaling pathway [GO:0038026]; regulation of behavior [GO:0050795]; regulation of neuron differentiation [GO:0045664]; regulation of neuron migration [GO:2001222]; regulation of NMDA receptor activity [GO:2000310]; regulation of synaptic activity [GO:0060025]; response to pain [GO:0048265]; spinal cord patterning [GO:0021511]; ventral spinal cord development [GO:0021517]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
P78524	reviewed	DEN2B_HUMAN	DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein)	DENND2B HTS1 ST5	Homo sapiens (Human)	1137	FUNCTION: [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000305}.	positive regulation of ERK1 and ERK2 cascade [GO:0070374]	cell cortex [GO:0005938]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	guanyl-nucleotide exchange factor activity [GO:0005085]	cell cortex [GO:0005938]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; guanyl-nucleotide exchange factor activity [GO:0005085]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cell cortex {ECO:0000269|PubMed:29030480}. Cell membrane {ECO:0000269|PubMed:29030480}. Recycling endosome {ECO:0000269|PubMed:29030480}. Note=Colocalizes with RAB13 and ITSN1 at cytoplasmic vesicles that are most likely recycling endosomes. Colocalizes with the cortical actin cytoskeleton. {ECO:0000269|PubMed:29030480}.
P78527	reviewed	PRKDC_HUMAN	DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)	PRKDC HYRC HYRC1	Homo sapiens (Human)	4128	FUNCTION: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:15574326, PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:15574326, PubMed:11955432, PubMed:12649176, PubMed:14734805). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:15574326, PubMed:11955432, PubMed:12649176, PubMed:14734805). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:15574326, PubMed:11955432, PubMed:12649176, PubMed:14734805). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:15574326, PubMed:11955432, PubMed:12649176, PubMed:14734805). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:2507541, PubMed:2247066, PubMed:1597196, PubMed:8407951, PubMed:8464713, PubMed:9362500, PubMed:9139719, PubMed:10026262, PubMed:10467406, PubMed:12509254, PubMed:11889123, PubMed:14612514, PubMed:14599745, PubMed:15177042, PubMed:18644470, PubMed:26666690, PubMed:30247612, PubMed:14704337, PubMed:16397295, PubMed:26237645, PubMed:28712728, PubMed:29478807). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}.		activation of innate immune response [GO:0002218]; B cell lineage commitment [GO:0002326]; brain development [GO:0007420]; cellular response to insulin stimulus [GO:0032869]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via nonhomologous end joining [GO:0006303]; ectopic germ cell programmed cell death [GO:0035234]; heart development [GO:0007507]; immature B cell differentiation [GO:0002327]; immunoglobulin V(D)J recombination [GO:0033152]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; maturation of 5.8S rRNA [GO:0000460]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic process [GO:0043065]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of platelet formation [GO:1905221]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; pro-B cell differentiation [GO:0002328]; protein destabilization [GO:0031648]; protein modification process [GO:0036211]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of epithelial cell proliferation [GO:0050678]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of smooth muscle cell proliferation [GO:0048660]; response to gamma radiation [GO:0010332]; rhythmic process [GO:0048511]; small-subunit processome assembly [GO:0034462]; somitogenesis [GO:0001756]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell receptor V(D)J recombination [GO:0033153]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; small-subunit processome [GO:0032040]; transcription regulator complex [GO:0005667]	ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; U3 snoRNA binding [GO:0034511]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; small-subunit processome [GO:0032040]; transcription regulator complex [GO:0005667]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; U3 snoRNA binding [GO:0034511]; activation of innate immune response [GO:0002218]; B cell lineage commitment [GO:0002326]; brain development [GO:0007420]; cellular response to insulin stimulus [GO:0032869]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via nonhomologous end joining [GO:0006303]; ectopic germ cell programmed cell death [GO:0035234]; heart development [GO:0007507]; immature B cell differentiation [GO:0002327]; immunoglobulin V(D)J recombination [GO:0033152]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; maturation of 5.8S rRNA [GO:0000460]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic process [GO:0043065]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of platelet formation [GO:1905221]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; pro-B cell differentiation [GO:0002328]; protein destabilization [GO:0031648]; protein modification process [GO:0036211]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of epithelial cell proliferation [GO:0050678]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of smooth muscle cell proliferation [GO:0048660]; response to gamma radiation [GO:0010332]; rhythmic process [GO:0048511]; small-subunit processome assembly [GO:0034462]; somitogenesis [GO:0001756]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell receptor V(D)J recombination [GO:0033153]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12231622, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:22002106}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:32103174}.
P78536	reviewed	ADA17_HUMAN	Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)	ADAM17 CSVP TACE	Homo sapiens (Human)	824	FUNCTION: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:24337742, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:9034191}.		amyloid precursor protein catabolic process [GO:0042987]; B cell differentiation [GO:0030183]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell motility [GO:0048870]; cellular response to high density lipoprotein particle stimulus [GO:0071403]; commissural neuron axon guidance [GO:0071679]; defense response to Gram-positive bacterium [GO:0050830]; germinal center formation [GO:0002467]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neutrophil mediated immunity [GO:0002446]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein processing [GO:0016485]; proteolysis [GO:0006508]; receptor transactivation [GO:0035624]; regulation of mast cell apoptotic process [GO:0033025]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to xenobiotic stimulus [GO:0009410]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; wound healing, spreading of epidermal cells [GO:0035313]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; interleukin-6 receptor binding [GO:0005138]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; Notch binding [GO:0005112]; PDZ domain binding [GO:0030165]; peptidase activity [GO:0008233]; SH3 domain binding [GO:0017124]; tumor necrosis factor binding [GO:0043120]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; interleukin-6 receptor binding [GO:0005138]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; Notch binding [GO:0005112]; PDZ domain binding [GO:0030165]; peptidase activity [GO:0008233]; SH3 domain binding [GO:0017124]; tumor necrosis factor binding [GO:0043120]; amyloid precursor protein catabolic process [GO:0042987]; B cell differentiation [GO:0030183]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell motility [GO:0048870]; cellular response to high density lipoprotein particle stimulus [GO:0071403]; commissural neuron axon guidance [GO:0071679]; defense response to Gram-positive bacterium [GO:0050830]; germinal center formation [GO:0002467]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neutrophil mediated immunity [GO:0002446]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein processing [GO:0016485]; proteolysis [GO:0006508]; receptor transactivation [GO:0035624]; regulation of mast cell apoptotic process [GO:0033025]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to xenobiotic stimulus [GO:0009410]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P78537	reviewed	BL1S1_HUMAN	Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC-1 subunit 1) (GCN5-like protein 1) (Protein RT14)	BLOC1S1 BLOS1 GCN5L1 RT14	Homo sapiens (Human)	153	FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:17182842). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:25898167}.; FUNCTION: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. {ECO:0000269|PubMed:22309213}.	MISCELLANEOUS: [Isoform 2]: May be produced by alternative initiation at Met-27 of isoform 1. A polymorphism at position 9 leads to the creation of a stop codon. Isoform 2 is the only form that exists in orthologs (except primates). {ECO:0000305}.	aerobic respiration [GO:0009060]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosomal transport [GO:0016197]; lysosome localization [GO:0032418]; melanosome organization [GO:0032438]; neuron projection development [GO:0031175]; organelle transport along microtubule [GO:0072384]; peptidyl-lysine acetylation [GO:0018394]; platelet dense granule organization [GO:0060155]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]	axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]		axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; aerobic respiration [GO:0009060]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosomal transport [GO:0016197]; lysosome localization [GO:0032418]; melanosome organization [GO:0032438]; neuron projection development [GO:0031175]; organelle transport along microtubule [GO:0072384]; peptidyl-lysine acetylation [GO:0018394]; platelet dense granule organization [GO:0060155]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:22309213}. Mitochondrion matrix {ECO:0000269|PubMed:22309213}. Cytoplasm, cytosol {ECO:0000269|PubMed:22309213}. Lysosome membrane {ECO:0000305|PubMed:25898167}.
P78539	reviewed	SRPX_HUMAN	Sushi repeat-containing protein SRPX	SRPX ETX1	Homo sapiens (Human)	464	FUNCTION: May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction.		autophagy [GO:0006914]; cell adhesion [GO:0007155]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; phagolysosome assembly [GO:0001845]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; response to endoplasmic reticulum stress [GO:0034976]	autophagosome [GO:0005776]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]		autophagosome [GO:0005776]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; autophagy [GO:0006914]; cell adhesion [GO:0007155]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; phagolysosome assembly [GO:0001845]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Cell surface {ECO:0000305}. Note=Possibly surface of photoreceptor cell.
P78540	reviewed	ARGI2_HUMAN	Arginase-2, mitochondrial (EC 3.5.3.1) (Arginase II) (Kidney-type arginase) (Non-hepatic arginase) (Type II arginase)	ARG2	Homo sapiens (Human)	354	FUNCTION: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189). {ECO:0000250|UniProtKB:O08691, ECO:0000269|PubMed:12859189, ECO:0000269|PubMed:22928666, ECO:0000269|PubMed:23832324, ECO:0000269|PubMed:25484082, ECO:0000269|PubMed:27214549, ECO:0000269|PubMed:27745970}.		adaptive immune response [GO:0002250]; arginine catabolic process to ornithine [GO:0019547]; innate immune response [GO:0045087]; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process [GO:1905403]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of chemokine (C-C motif) ligand 4 production [GO:0071644]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of defense response to bacterium [GO:1900425]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type 2 immune response [GO:0002829]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of cellular senescence [GO:2000774]; regulation of interleukin-1 beta production [GO:0032651]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; striated muscle contraction [GO:0006941]; urea cycle [GO:0000050]; ureteric bud development [GO:0001657]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	arginase activity [GO:0004053]; manganese ion binding [GO:0030145]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; arginase activity [GO:0004053]; manganese ion binding [GO:0030145]; adaptive immune response [GO:0002250]; arginine catabolic process to ornithine [GO:0019547]; innate immune response [GO:0045087]; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process [GO:1905403]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of chemokine (C-C motif) ligand 4 production [GO:0071644]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of defense response to bacterium [GO:1900425]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type 2 immune response [GO:0002829]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of cellular senescence [GO:2000774]; regulation of interleukin-1 beta production [GO:0032651]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; striated muscle contraction [GO:0006941]; urea cycle [GO:0000050]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:8898077}.
P78543	reviewed	BTG2_HUMAN	Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3)	BTG2 PC3	Homo sapiens (Human)	158	FUNCTION: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. {ECO:0000250, ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:18337750, ECO:0000269|PubMed:18773938, ECO:0000269|PubMed:23236473}.		anterior/posterior pattern specification [GO:0009952]; associative learning [GO:0008306]; central nervous system neuron development [GO:0021954]; dentate gyrus development [GO:0021542]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; neuroblast proliferation [GO:0007405]; neuron projection development [GO:0031175]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; response to electrical stimulus [GO:0051602]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; response to peptide hormone [GO:0043434]; skeletal muscle cell differentiation [GO:0035914]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; transcription corepressor activity [GO:0003714]; anterior/posterior pattern specification [GO:0009952]; associative learning [GO:0008306]; central nervous system neuron development [GO:0021954]; dentate gyrus development [GO:0021542]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; neuroblast proliferation [GO:0007405]; neuron projection development [GO:0031175]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; response to electrical stimulus [GO:0051602]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; response to peptide hormone [GO:0043434]; skeletal muscle cell differentiation [GO:0035914]	
P78545	reviewed	ELF3_HUMAN	ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1)	ELF3 ERT ESX JEN	Homo sapiens (Human)	371	FUNCTION: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:10644990, ECO:0000269|PubMed:10773884, ECO:0000269|PubMed:11036073, ECO:0000269|PubMed:11313868, ECO:0000269|PubMed:12414801, ECO:0000269|PubMed:12624109, ECO:0000269|PubMed:12682075, ECO:0000269|PubMed:12713734, ECO:0000269|PubMed:14715662, ECO:0000269|PubMed:14767472, ECO:0000269|PubMed:15075319, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:15794755, ECO:0000269|PubMed:16307850, ECO:0000269|PubMed:17060315, ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700, ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241, ECO:0000269|PubMed:9417054}.		blastocyst development [GO:0001824]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; inflammatory response [GO:0006954]; mammary gland involution [GO:0060056]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; blastocyst development [GO:0001824]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; inflammatory response [GO:0006954]; mammary gland involution [GO:0060056]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}. Note=Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. {ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}.
P78549	reviewed	NTH_HUMAN	Endonuclease III-like protein 1 (hNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)	NTHL1 NTH1 OCTS3	Homo sapiens (Human)	312	FUNCTION: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage (PubMed:9927729, PubMed:29610152). The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:10882850, ECO:0000269|PubMed:11328882, ECO:0000269|PubMed:11380260, ECO:0000269|PubMed:11695910, ECO:0000269|PubMed:12140329, ECO:0000269|PubMed:12144783, ECO:0000269|PubMed:12519758, ECO:0000269|PubMed:14734554, ECO:0000269|PubMed:15533839, ECO:0000269|PubMed:17923696, ECO:0000269|PubMed:20005182, ECO:0000269|PubMed:20110254, ECO:0000269|PubMed:21930793, ECO:0000269|PubMed:29610152, ECO:0000269|PubMed:8990169, ECO:0000269|PubMed:9045706, ECO:0000269|PubMed:9705289, ECO:0000269|PubMed:9890904, ECO:0000269|PubMed:9927729}.		base-excision repair, AP site formation [GO:0006285]; depyrimidination [GO:0045008]; nucleotide-excision repair [GO:0006289]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	4 iron, 4 sulfur cluster binding [GO:0051539]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 4 iron, 4 sulfur cluster binding [GO:0051539]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]; base-excision repair, AP site formation [GO:0006285]; depyrimidination [GO:0045008]; nucleotide-excision repair [GO:0006289]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:10882850, ECO:0000269|PubMed:12531031, ECO:0000269|PubMed:9611236}. Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:9611236}.
P78552	reviewed	I13R1_HUMAN	Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1)	IL13RA1 IL13R IL13RA	Homo sapiens (Human)	427	FUNCTION: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.		cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; positive regulation of cell population proliferation [GO:0008284]	external side of plasma membrane [GO:0009897]; interleukin-13 receptor complex [GO:0005898]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]	external side of plasma membrane [GO:0009897]; interleukin-13 receptor complex [GO:0005898]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P78556	reviewed	CCL20_HUMAN	C-C motif chemokine 20 (Beta-chemokine exodus-1) (CC chemokine LARC) (Liver and activation-regulated chemokine) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Small-inducible cytokine A20) [Cleaved into: CCL20(1-67); CCL20(1-64); CCL20(2-70)]	CCL20 LARC MIP3A SCYA20	Homo sapiens (Human)	96	FUNCTION: Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255). {ECO:0000250|UniProtKB:O89093, ECO:0000269|PubMed:11035086, ECO:0000269|PubMed:11352563, ECO:0000269|PubMed:12149255, ECO:0000269|PubMed:20068036, ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:25122636, ECO:0000269|PubMed:9038201, ECO:0000269|PubMed:9129037, ECO:0000303|PubMed:21376174}.		calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell chemotaxis [GO:0060326]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of T cell migration [GO:2000406]; signal transduction [GO:0007165]; T cell migration [GO:0072678]; thymocyte migration [GO:0072679]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR6 chemokine receptor binding [GO:0031731]; chemokine activity [GO:0008009]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR6 chemokine receptor binding [GO:0031731]; chemokine activity [GO:0008009]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell chemotaxis [GO:0060326]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of T cell migration [GO:2000406]; signal transduction [GO:0007165]; T cell migration [GO:0072678]; thymocyte migration [GO:0072679]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11035086}.
P78559	reviewed	MAP1A_HUMAN	Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]	MAP1A MAP1L	Homo sapiens (Human)	2803	FUNCTION: Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.		anterograde axonal protein transport [GO:0099641]; associative learning [GO:0008306]; axonogenesis [GO:0007409]; dendrite development [GO:0016358]; memory [GO:0007613]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein localization to microtubule [GO:1902817]; neuron cellular homeostasis [GO:0070050]; neuron projection maintenance [GO:1990535]; positive regulation of protein localization [GO:1903829]; positive regulation of protein localization to cell surface [GO:2000010]; regulation of microtubule depolymerization [GO:0031114]; regulation of synaptic plasticity [GO:0048167]; retrograde axonal protein transport [GO:0099642]; voluntary musculoskeletal movement [GO:0050882]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic branch [GO:0044307]; dendritic microtubule [GO:1901588]; dendritic shaft [GO:0043198]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; primary dendrite [GO:0150001]; synapse [GO:0045202]	actin binding [GO:0003779]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; tubulin binding [GO:0015631]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic branch [GO:0044307]; dendritic microtubule [GO:1901588]; dendritic shaft [GO:0043198]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; primary dendrite [GO:0150001]; synapse [GO:0045202]; actin binding [GO:0003779]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; tubulin binding [GO:0015631]; anterograde axonal protein transport [GO:0099641]; associative learning [GO:0008306]; axonogenesis [GO:0007409]; dendrite development [GO:0016358]; memory [GO:0007613]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein localization to microtubule [GO:1902817]; neuron cellular homeostasis [GO:0070050]; neuron projection maintenance [GO:1990535]; positive regulation of protein localization [GO:1903829]; positive regulation of protein localization to cell surface [GO:2000010]; regulation of microtubule depolymerization [GO:0031114]; regulation of synaptic plasticity [GO:0048167]; retrograde axonal protein transport [GO:0099642]; voluntary musculoskeletal movement [GO:0050882]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
P78560	reviewed	CRADD_HUMAN	Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain)	CRADD RAIDD	Homo sapiens (Human)	199	FUNCTION: Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253). {ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:16652156, ECO:0000269|PubMed:17159900, ECO:0000269|PubMed:17289572, ECO:0000269|PubMed:8985253, ECO:0000269|PubMed:9044836}.		apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; nucleolus [GO:0005730]; nucleus [GO:0005634]	death domain binding [GO:0070513]; protease binding [GO:0002020]; protein-macromolecule adaptor activity [GO:0030674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; nucleolus [GO:0005730]; nucleus [GO:0005634]; death domain binding [GO:0070513]; protease binding [GO:0002020]; protein-macromolecule adaptor activity [GO:0030674]; apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O88843}. Nucleus {ECO:0000250|UniProtKB:O88843}.
P78562	reviewed	PHEX_HUMAN	Phosphate-regulating neutral endopeptidase PHEX (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (Vitamin D-resistant hypophosphatemic rickets protein) (X-linked hypophosphatemia protein) (HYP)	PHEX PEX	Homo sapiens (Human)	749	FUNCTION: Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (PubMed:9593714, PubMed:15664000, PubMed:18162525, PubMed:18597632). Cleaves ASARM peptides between Ser and Glu or Asp residues (PubMed:18597632). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:18597632). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:18597632, PubMed:18162525). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (PubMed:12220505). {ECO:0000250|UniProtKB:P70669, ECO:0000269|PubMed:12220505, ECO:0000269|PubMed:18162525, ECO:0000269|PubMed:18597632}.		bone development [GO:0060348]; bone mineralization [GO:0030282]; cell-cell signaling [GO:0007267]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to vitamin D [GO:0071305]; lung development [GO:0030324]; odontogenesis [GO:0042476]; organophosphate metabolic process [GO:0019637]; protein modification process [GO:0036211]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to growth hormone [GO:0060416]; response to insulin-like growth factor stimulus [GO:1990418]; response to sodium phosphate [GO:1904383]; skeletal system development [GO:0001501]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; bone development [GO:0060348]; bone mineralization [GO:0030282]; cell-cell signaling [GO:0007267]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to vitamin D [GO:0071305]; lung development [GO:0030324]; odontogenesis [GO:0042476]; organophosphate metabolic process [GO:0019637]; protein modification process [GO:0036211]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to growth hormone [GO:0060416]; response to insulin-like growth factor stimulus [GO:1990418]; response to sodium phosphate [GO:1904383]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9593714}; Single-pass type II membrane protein {ECO:0000269|PubMed:9593714}.
P78563	reviewed	RED1_HUMAN	Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase)	ADARB1 ADAR2 DRADA2 RED1	Homo sapiens (Human)	741	FUNCTION: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}.	MISCELLANEOUS: [Isoform 1]: Alu insert from position 465 to 505. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; MISCELLANEOUS: [Isoform 5]: Likely expressed from an alternative promoter. Contains a region highly similar to the so-called ssRNA-binding R-domain of ADARB2. {ECO:0000269|PubMed:19156214}.	adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; defense response to virus [GO:0051607]; facial nerve morphogenesis [GO:0021610]; hypoglossal nerve morphogenesis [GO:0021618]; innate immune response [GO:0045087]; innervation [GO:0060384]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; muscle tissue morphogenesis [GO:0060415]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; neuromuscular process controlling posture [GO:0050884]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of viral genome replication [GO:0045070]; regulation of cell cycle [GO:0051726]; RNA processing [GO:0006396]; spinal cord ventral commissure morphogenesis [GO:0021965]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]	double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251]; adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; defense response to virus [GO:0051607]; facial nerve morphogenesis [GO:0021610]; hypoglossal nerve morphogenesis [GO:0021618]; innate immune response [GO:0045087]; innervation [GO:0060384]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; muscle tissue morphogenesis [GO:0060415]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; neuromuscular process controlling posture [GO:0050884]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of viral genome replication [GO:0045070]; regulation of cell cycle [GO:0051726]; RNA processing [GO:0006396]; spinal cord ventral commissure morphogenesis [GO:0021965]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32220291}. Nucleus, nucleolus {ECO:0000269|PubMed:32220291}. Note=Shuttles between nucleoli and the nucleoplasm. {ECO:0000305|PubMed:32220291}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:32220291}. Nucleus, nucleolus {ECO:0000269|PubMed:32220291}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:32220291}. Nucleus, nucleolus {ECO:0000269|PubMed:32220291}.
P79483	reviewed	DRB3_HUMAN	HLA class II histocompatibility antigen, DR beta 3 chain (MHC class II antigen DRB3)	HLA-DRB3	Homo sapiens (Human)	266	FUNCTION: A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB3-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:2788702, PubMed:2463305, PubMed:16148104, PubMed:19531622, PubMed:20368442, PubMed:19830726, PubMed:23569328, PubMed:22929521, PubMed:30282837, PubMed:31020640, PubMed:31333679, PubMed:31308093). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (By similarity). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (By similarity). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides. The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (By similarity). {ECO:0000250|UniProtKB:P01911, ECO:0000269|PubMed:16148104, ECO:0000269|PubMed:19531622, ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:20368442, ECO:0000269|PubMed:22929521, ECO:0000269|PubMed:23569328, ECO:0000269|PubMed:2463305, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:30282837, ECO:0000269|PubMed:31020640, ECO:0000269|PubMed:31308093, ECO:0000269|PubMed:31333679}.; FUNCTION: ALLELE DRB3*01:01: Exclusively presents several immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a significant role in immune recognition and long-term protection (PubMed:19830726, PubMed:2788702, PubMed:2463305). Presents viral epitopes derived from HHV-6B U11, TRX2/U56 and U85 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). {ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:2463305, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:31020640}.; FUNCTION: ALLELE DRB3*02:02 Exclusively presents several immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a significant role in immune recognition and long-term protection (PubMed:19830726, PubMed:2788702). Upon EBV infection, presents to CD4-positive T cells latent antigen EBNA2 (PRSPTVFYNIPPMPLPPSQL) and lytic antigen BZLF1 (LTAYHVSTAPTGSWF) peptides, driving oligoclonal expansion and selection of virus-specific memory T cell subsets with cytotoxic potential to directly eliminate virus-infected B cells (PubMed:31308093, PubMed:23569328). Presents viral epitopes derived from HHV-6B U11, gB/U39 and gH/U48 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). Plays a minor role in CD4-positive T cell immune response against Dengue virus by presenting conserved peptides from capsid and non-structural NS3 proteins (PubMed:31333679). Displays peptides derived from IAV matrix protein M, implying a role in protection against IAV infection (PubMed:19830726). In the context of tumor immunesurveillance, may present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:22929521). Presents to Vbeta2-positive T-helper 1 cells specifically an immunodominant peptide derived from tumor antigen CTAG1A/NY-ESO-1(PGVLLKEFTVSGNILTIRLTAADHR) and confers protective memory response (PubMed:19531622, PubMed:20368442). In metastatic epithelial tumors, presents to intratumoral CD4-positive T cells a TP53 neoantigen (HYNYMCNSSCMGSMNRRPILTIITL) carrying G245S hotspot driver mutation and may mediate tumor regression (PubMed:30282837). {ECO:0000269|PubMed:19531622, ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:20368442, ECO:0000269|PubMed:22929521, ECO:0000269|PubMed:23569328, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:30282837, ECO:0000269|PubMed:31020640, ECO:0000269|PubMed:31308093, ECO:0000269|PubMed:31333679}.; FUNCTION: ALLELE DRB3*03:01: Presents a series of conserved peptides derived from the M. tuberculosis PPE family of proteins, in particular PPE29 and PPE33, known to be highly immunogenic (PubMed:32341563). Presents immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a role in immune recognition and long-term protection (PubMed:2788702). Displays immunodominant viral peptides from HCV non-structural protein NS2, as part of a broad range T-helper response to resolve infection (PubMed:16148104). {ECO:0000269|PubMed:16148104, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:32341563}.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; myeloid dendritic cell antigen processing and presentation [GO:0002469]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]	MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; myeloid dendritic cell antigen processing and presentation [GO:0002469]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:19531622, ECO:0000269|PubMed:19830726}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000255}. Autolysosome membrane {ECO:0000250|UniProtKB:P01911}; Single-pass type I membrane protein {ECO:0000255}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:18305173). Component of immunological synapses at the interface between T cell and APC. {ECO:0000250|UniProtKB:P01911}.
P79522	reviewed	PRR3_HUMAN	Proline-rich protein 3 (MHC class I region proline-rich protein CAT56)	PRR3 CAT56	Homo sapiens (Human)	188					metal ion binding [GO:0046872]; RNA binding [GO:0003723]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	
P80075	reviewed	CCL8_HUMAN	C-C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8) [Cleaved into: MCP-2(6-76)]	CCL8 MCP2 SCYA10 SCYA8	Homo sapiens (Human)	99	FUNCTION: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. {ECO:0000269|PubMed:9558113}.		calcium ion transport [GO:0006816]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; negative regulation by host of viral genome replication [GO:0044828]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; response to virus [GO:0009615]; signal transduction [GO:0007165]	extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; heparin binding [GO:0008201]; phospholipase activator activity [GO:0016004]; protein kinase activity [GO:0004672]	extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; heparin binding [GO:0008201]; phospholipase activator activity [GO:0016004]; protein kinase activity [GO:0004672]; calcium ion transport [GO:0006816]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; negative regulation by host of viral genome replication [GO:0044828]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; response to virus [GO:0009615]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P80098	reviewed	CCL7_HUMAN	C-C motif chemokine 7 (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP-3) (NC28) (Small-inducible cytokine A7)	CCL7 MCP3 SCYA6 SCYA7	Homo sapiens (Human)	99	FUNCTION: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.		cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of natural killer cell chemotaxis [GO:2000503]; regulation of cell shape [GO:0008360]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR1 chemokine receptor binding [GO:0031726]; chemokine activity [GO:0008009]; heparin binding [GO:0008201]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR1 chemokine receptor binding [GO:0031726]; chemokine activity [GO:0008009]; heparin binding [GO:0008201]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of natural killer cell chemotaxis [GO:2000503]; regulation of cell shape [GO:0008360]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P80108	reviewed	PHLD_HUMAN	Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D)	GPLD1 PIGPLD1	Homo sapiens (Human)	840	FUNCTION: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.		cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to calcium ion [GO:0071277]; cellular response to cholesterol [GO:0071397]; cellular response to insulin stimulus [GO:0032869]; cellular response to pH [GO:0071467]; cellular response to triglyceride [GO:0071401]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; complement receptor mediated signaling pathway [GO:0002430]; GPI anchor release [GO:0006507]; hematopoietic stem cell migration [GO:0035701]; hematopoietic stem cell migration to bone marrow [GO:0097241]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of triglyceride catabolic process [GO:0010897]; ossification [GO:0001503]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of secretion [GO:0051047]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of cellular response to insulin stimulus [GO:1900076]; response to glucose [GO:0009749]; transepithelial transport [GO:0070633]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]	glycosylphosphatidylinositol phospholipase D activity [GO:0004621]; phospholipase D activity [GO:0004630]; sodium channel regulator activity [GO:0017080]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; glycosylphosphatidylinositol phospholipase D activity [GO:0004621]; phospholipase D activity [GO:0004630]; sodium channel regulator activity [GO:0017080]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to calcium ion [GO:0071277]; cellular response to cholesterol [GO:0071397]; cellular response to insulin stimulus [GO:0032869]; cellular response to pH [GO:0071467]; cellular response to triglyceride [GO:0071401]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; complement receptor mediated signaling pathway [GO:0002430]; GPI anchor release [GO:0006507]; hematopoietic stem cell migration [GO:0035701]; hematopoietic stem cell migration to bone marrow [GO:0097241]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of triglyceride catabolic process [GO:0010897]; ossification [GO:0001503]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of secretion [GO:0051047]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of cellular response to insulin stimulus [GO:1900076]; response to glucose [GO:0009749]; transepithelial transport [GO:0070633]	SUBCELLULAR LOCATION: Secreted.
P80162	reviewed	CXCL6_HUMAN	C-X-C motif chemokine 6 (Chemokine alpha 3) (CKA-3) (Granulocyte chemotactic protein 2) (GCP-2) (Small-inducible cytokine B6) [Cleaved into: Small-inducible cytokine B6, N-processed variant 1; Small-inducible cytokine B6, N-processed variant 2; Small-inducible cytokine B6, N-processed variant 3]	CXCL6 GCP2 SCYB6	Homo sapiens (Human)	114	FUNCTION: Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7). {ECO:0000269|PubMed:18443119, ECO:0000269|PubMed:8399143, ECO:0000269|PubMed:8423327, ECO:0000269|PubMed:9057843}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; inflammatory response [GO:0006954]; leukocyte homeostasis [GO:0001776]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; regulation of chemokine production [GO:0032642]; regulation of neutrophil mediated killing of gram-negative bacterium [GO:0070951]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; heparin binding [GO:0008201]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; heparin binding [GO:0008201]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; inflammatory response [GO:0006954]; leukocyte homeostasis [GO:0001776]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; regulation of chemokine production [GO:0032642]; regulation of neutrophil mediated killing of gram-negative bacterium [GO:0070951]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P80188	reviewed	NGAL_HUMAN	Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin) (p25)	LCN2 HNL NGAL	Homo sapiens (Human)	198	FUNCTION: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864). Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368). {ECO:0000250|UniProtKB:P11672, ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:15642259, ECO:0000269|PubMed:20581821, ECO:0000269|PubMed:21978368, ECO:0000269|PubMed:27780864}.		apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; iron ion transmembrane transport [GO:0034755]; positive regulation of cold-induced thermogenesis [GO:0120162]; siderophore transport [GO:0015891]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]	enterobactin binding [GO:1903981]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; iron ion sequestering activity [GO:0140315]; small molecule binding [GO:0036094]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; enterobactin binding [GO:1903981]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; iron ion sequestering activity [GO:0140315]; small molecule binding [GO:0036094]; apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; iron ion transmembrane transport [GO:0034755]; positive regulation of cold-induced thermogenesis [GO:0120162]; siderophore transport [GO:0015891]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:27780864, ECO:0000269|PubMed:7683678}. Cytoplasmic granule lumen {ECO:0000269|PubMed:8298140}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:12453413}. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (By similarity). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (PubMed:12453413, PubMed:20581821). {ECO:0000250|UniProtKB:P11672, ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:20581821}.
P80192	reviewed	M3K9_HUMAN	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1)	MAP3K9 MLK1 PRKE1	Homo sapiens (Human)	1104	FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269|PubMed:11416147, ECO:0000269|PubMed:15610029}.		apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]		ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase activity [GO:0004708]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase activity [GO:0004708]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	
P80217	reviewed	IN35_HUMAN	Interferon-induced 35 kDa protein (IFP 35) (Ifi-35)	IFI35 IFP35	Homo sapiens (Human)	286	FUNCTION: Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465). {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:29350881}.	MISCELLANEOUS: [Isoform 2]: Due to a polymorphism at the 3'-splice acceptor site of intron 4. {ECO:0000305}.	innate immune response [GO:0045087]; macrophage activation involved in immune response [GO:0002281]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; innate immune response [GO:0045087]; macrophage activation involved in immune response [GO:0002281]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:8288566}. Nucleus {ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:8288566}. Secreted {ECO:0000269|PubMed:29038465}. Note=Cytoplasmic IFI35 localizes in punctate granular structures (PubMed:10950963). Nuclear localization increased is stimulated by IFN-alpha (PubMed:8288566, PubMed:10950963). Extracelullar following secretion by macrophage (PubMed:29038465). {ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:8288566}.
P80294	reviewed	MT1H_HUMAN	Metallothionein-1H (MT-1H) (Metallothionein-0) (MT-0) (Metallothionein-IH) (MT-IH)	MT1H	Homo sapiens (Human)	61	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.		cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	
P80297	reviewed	MT1X_HUMAN	Metallothionein-1X (MT-1X) (Metallothionein-IX) (MT-IX)	MT1X	Homo sapiens (Human)	61	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525). {ECO:0000269|PubMed:23251525}.		cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to erythropoietin [GO:0036018]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]; response to metal ion [GO:0010038]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to erythropoietin [GO:0036018]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]; response to metal ion [GO:0010038]	
P80303	reviewed	NUCB2_HUMAN	Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1]	NUCB2 NEFA	Homo sapiens (Human)	420	FUNCTION: Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. {ECO:0000250|UniProtKB:Q9JI85}.	MISCELLANEOUS: NEFA stands for N=DNA-binding; EF=EF-hand; A=Acidic region.	small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:11749975}. Membrane {ECO:0000269|PubMed:11749975}; Peripheral membrane protein {ECO:0000269|PubMed:11749975}. Cytoplasm {ECO:0000269|PubMed:11749975}. Secreted {ECO:0000269|PubMed:11749975}. Endoplasmic reticulum {ECO:0000250}. Nucleus envelope {ECO:0000250}. Note=Golgi retention is mediated by its N-terminal region.; SUBCELLULAR LOCATION: [Nesfatin-1]: Secreted.
P80365	reviewed	DHI2_HUMAN	11-beta-hydroxysteroid dehydrogenase type 2 (11-DH2) (11-beta-HSD2) (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type II) (11-HSD type II) (11-beta-HSD type II) (Corticosteroid 11-beta-dehydrogenase isozyme 2) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 3)	HSD11B2 HSD11K SDR9C3	Homo sapiens (Human)	405	FUNCTION: Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+) (PubMed:7859916, PubMed:8538347, PubMed:10497248, PubMed:22796344, PubMed:27927697, PubMed:30902677, PubMed:33387577, PubMed:12788846, PubMed:17314322). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (PubMed:7859916, PubMed:10497248, PubMed:33387577, PubMed:12788846, PubMed:17314322). Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure (By similarity). Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen (PubMed:22796344, PubMed:27927697). Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone (PubMed:27927697). Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro (PubMed:30902677). 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (PubMed:30902677). May protect ovulating oocytes and fertilizing spermatozoa from the adverse effects of cortisol (By similarity). {ECO:0000250|UniProtKB:O77667, ECO:0000250|UniProtKB:P51661, ECO:0000269|PubMed:10497248, ECO:0000269|PubMed:12788846, ECO:0000269|PubMed:17314322, ECO:0000269|PubMed:22796344, ECO:0000269|PubMed:27927697, ECO:0000269|PubMed:30902677, ECO:0000269|PubMed:33387577, ECO:0000269|PubMed:7859916, ECO:0000269|PubMed:8538347, ECO:0000303|PubMed:30902677}.	MISCELLANEOUS: Consumption of large amounts of liquorice can lead to apparent mineralocorticoid excess and hypertension.	cortisol metabolic process [GO:0034650]; female pregnancy [GO:0007565]; glucocorticoid metabolic process [GO:0008211]; regulation of blood volume by renal aldosterone [GO:0002017]; response to food [GO:0032094]; response to glucocorticoid [GO:0051384]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	11-beta-hydroxysteroid dehydrogenase (NAD+) activity [GO:0070523]; NAD binding [GO:0051287]; steroid binding [GO:0005496]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; 11-beta-hydroxysteroid dehydrogenase (NAD+) activity [GO:0070523]; NAD binding [GO:0051287]; steroid binding [GO:0005496]; cortisol metabolic process [GO:0034650]; female pregnancy [GO:0007565]; glucocorticoid metabolic process [GO:0008211]; regulation of blood volume by renal aldosterone [GO:0002017]; response to food [GO:0032094]; response to glucocorticoid [GO:0051384]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Microsome {ECO:0000269|PubMed:17314322}. Endoplasmic reticulum {ECO:0000269|PubMed:10497248, ECO:0000269|PubMed:17314322}.
P80370	reviewed	DLK1_HUMAN	Protein delta homolog 1 (DLK-1) (pG2) [Cleaved into: Fetal antigen 1 (FA1)]	DLK1 DLK	Homo sapiens (Human)	383	FUNCTION: May have a role in neuroendocrine differentiation.		cell differentiation [GO:0030154]; negative regulation of Notch signaling pathway [GO:0045746]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; cell differentiation [GO:0030154]; negative regulation of Notch signaling pathway [GO:0045746]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O70534}.
P80404	reviewed	GABT_HUMAN	4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)	ABAT GABAT	Homo sapiens (Human)	500	FUNCTION: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998). Can also convert delta-aminovalerate and beta-alanine (By similarity). {ECO:0000250|UniProtKB:P50554, ECO:0000269|PubMed:10407778, ECO:0000269|PubMed:15528998}.		behavioral response to cocaine [GO:0048148]; cerebellum development [GO:0021549]; copulation [GO:0007620]; exploration behavior [GO:0035640]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; gamma-aminobutyric acid catabolic process [GO:0009450]; gamma-aminobutyric acid metabolic process [GO:0009448]; locomotory behavior [GO:0007626]; negative regulation of blood pressure [GO:0045776]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; neurotransmitter catabolic process [GO:0042135]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of dopamine metabolic process [GO:0045964]; positive regulation of heat generation [GO:0031652]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of prolactin secretion [GO:1902722]; positive regulation of uterine smooth muscle contraction [GO:0070474]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410]	4-aminobutyrate transaminase complex [GO:0032144]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	(S)-3-amino-2-methylpropionate transaminase activity [GO:0047298]; 4-aminobutyrate:2-oxoglutarate transaminase activity [GO:0034386]; identical protein binding [GO:0042802]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; pyridoxal phosphate binding [GO:0030170]; succinate-semialdehyde dehydrogenase binding [GO:0032145]	4-aminobutyrate transaminase complex [GO:0032144]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; (S)-3-amino-2-methylpropionate transaminase activity [GO:0047298]; 4-aminobutyrate:2-oxoglutarate transaminase activity [GO:0034386]; identical protein binding [GO:0042802]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; pyridoxal phosphate binding [GO:0030170]; succinate-semialdehyde dehydrogenase binding [GO:0032145]; behavioral response to cocaine [GO:0048148]; cerebellum development [GO:0021549]; copulation [GO:0007620]; exploration behavior [GO:0035640]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; gamma-aminobutyric acid catabolic process [GO:0009450]; gamma-aminobutyric acid metabolic process [GO:0009448]; locomotory behavior [GO:0007626]; negative regulation of blood pressure [GO:0045776]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; neurotransmitter catabolic process [GO:0042135]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of dopamine metabolic process [GO:0045964]; positive regulation of heat generation [GO:0031652]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of prolactin secretion [GO:1902722]; positive regulation of uterine smooth muscle contraction [GO:0070474]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Mitochondrion matrix.
P80511	reviewed	S10AC_HUMAN	Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin]	S100A12	Homo sapiens (Human)	92	FUNCTION: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. {ECO:0000269|PubMed:11522286, ECO:0000269|PubMed:17208591, ECO:0000269|PubMed:18292089, ECO:0000269|PubMed:19386136}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; endothelial cell migration [GO:0043542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; mast cell activation [GO:0045576]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of inflammatory response [GO:0050729]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; RAGE receptor binding [GO:0050786]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; RAGE receptor binding [GO:0050786]; zinc ion binding [GO:0008270]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; endothelial cell migration [GO:0043542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; mast cell activation [GO:0045576]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of inflammatory response [GO:0050729]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22811950}. Cytoplasm {ECO:0000269|PubMed:22811950}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22811950}. Cell membrane {ECO:0000269|PubMed:22811950}; Peripheral membrane protein {ECO:0000269|PubMed:22811950}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.
P80723	reviewed	BASP1_HUMAN	Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22)	BASP1 NAP22	Homo sapiens (Human)	227			diaphragm development [GO:0060539]; gonad development [GO:0008406]; mesenchymal to epithelial transition [GO:0060231]; metanephric mesenchyme development [GO:0072075]; negative regulation of DNA-templated transcription [GO:0045892]; podocyte differentiation [GO:0072112]; positive regulation of heart growth [GO:0060421]; positive regulation of metanephric ureteric bud development [GO:2001076]; substantia nigra development [GO:0021762]; thorax and anterior abdomen determination [GO:0007356]	cell junction [GO:0030054]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; vesicle [GO:0031982]	protein domain specific binding [GO:0019904]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]	cell junction [GO:0030054]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; vesicle [GO:0031982]; protein domain specific binding [GO:0019904]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]; diaphragm development [GO:0060539]; gonad development [GO:0008406]; mesenchymal to epithelial transition [GO:0060231]; metanephric mesenchyme development [GO:0072075]; negative regulation of DNA-templated transcription [GO:0045892]; podocyte differentiation [GO:0072112]; positive regulation of heart growth [GO:0060421]; positive regulation of metanephric ureteric bud development [GO:2001076]; substantia nigra development [GO:0021762]; thorax and anterior abdomen determination [GO:0007356]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Cell projection, growth cone. Note=Associated with the membranes of growth cones that form the tips of elongating axons.
P81172	reviewed	HEPC_HUMAN	Hepcidin (Liver-expressed antimicrobial peptide 1) (LEAP-1) (Putative liver tumor regressor) (PLTR) [Cleaved into: Hepcidin-25 (Hepc25); Hepcidin-20 (Hepc20)]	HAMP HEPC LEAP1 UNQ487/PRO1003	Homo sapiens (Human)	84	FUNCTION: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342). Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005). {ECO:0000269|PubMed:22306005, ECO:0000269|PubMed:22682227, ECO:0000269|PubMed:29237594, ECO:0000269|PubMed:32814342}.; FUNCTION: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317). {ECO:0000269|PubMed:11034317, ECO:0000269|PubMed:11113131}.		defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; establishment of localization in cell [GO:0051649]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; killing of cells of another organism [GO:0031640]; macrophage activation [GO:0042116]; multicellular organismal-level iron ion homeostasis [GO:0060586]; myeloid cell homeostasis [GO:0002262]; negative regulation of bone resorption [GO:0045779]; negative regulation of inflammatory response [GO:0050728]; negative regulation of intestinal absorption [GO:1904479]; negative regulation of iron ion transmembrane transport [GO:0034760]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of macrophage activation [GO:0043032]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein catabolic process [GO:0030163]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to iron ion [GO:0010039]; transcription by RNA polymerase II [GO:0006366]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]	copper ion binding [GO:0005507]; hormone activity [GO:0005179]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; copper ion binding [GO:0005507]; hormone activity [GO:0005179]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; establishment of localization in cell [GO:0051649]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; killing of cells of another organism [GO:0031640]; macrophage activation [GO:0042116]; multicellular organismal-level iron ion homeostasis [GO:0060586]; myeloid cell homeostasis [GO:0002262]; negative regulation of bone resorption [GO:0045779]; negative regulation of inflammatory response [GO:0050728]; negative regulation of intestinal absorption [GO:1904479]; negative regulation of iron ion transmembrane transport [GO:0034760]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of macrophage activation [GO:0043032]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein catabolic process [GO:0030163]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to iron ion [GO:0010039]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11034317}.
P81274	reviewed	GPSM2_HUMAN	G-protein-signaling modulator 2 (Mosaic protein LGN)	GPSM2 LGN	Homo sapiens (Human)	684	FUNCTION: Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Also plays an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity). {ECO:0000250|UniProtKB:Q8VDU0, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22327364}.	MISCELLANEOUS: Dysfunction of LGN is associated with the phenotype of multiple micronuclei due to chromosomal mis-segregation and defect in cell division through mis-localization of mitotic spindle regulator protein NUMA1. {ECO:0000305}.	cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; G protein-coupled receptor signaling pathway [GO:0007186]; maintenance of centrosome location [GO:0051661]; mitotic spindle organization [GO:0007052]; positive regulation of protein localization to cell cortex [GO:1904778]; positive regulation of spindle assembly [GO:1905832]; Ran protein signal transduction [GO:0031291]; regulation of mitotic spindle organization [GO:0060236]	cell cortex [GO:0005938]; cell cortex region [GO:0099738]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral cell cortex [GO:0097575]; lateral plasma membrane [GO:0016328]; mitotic spindle pole [GO:0097431]; protein-containing complex [GO:0032991]	dynein complex binding [GO:0070840]; G-protein alpha-subunit binding [GO:0001965]; GDP-dissociation inhibitor activity [GO:0005092]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; protein domain specific binding [GO:0019904]; protein self-association [GO:0043621]	cell cortex [GO:0005938]; cell cortex region [GO:0099738]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral cell cortex [GO:0097575]; lateral plasma membrane [GO:0016328]; mitotic spindle pole [GO:0097431]; protein-containing complex [GO:0032991]; dynein complex binding [GO:0070840]; G-protein alpha-subunit binding [GO:0001965]; GDP-dissociation inhibitor activity [GO:0005092]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; protein domain specific binding [GO:0019904]; protein self-association [GO:0043621]; cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; G protein-coupled receptor signaling pathway [GO:0007186]; maintenance of centrosome location [GO:0051661]; mitotic spindle organization [GO:0007052]; positive regulation of protein localization to cell cortex [GO:1904778]; positive regulation of spindle assembly [GO:1905832]; Ran protein signal transduction [GO:0031291]; regulation of mitotic spindle organization [GO:0060236]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:22074847}. Cytoplasm, cell cortex {ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22074847, ECO:0000269|PubMed:22327364}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:21816348}. Lateral cell membrane {ECO:0000269|PubMed:26766442}. Note=Localizes in the cytoplasm during interphase and at cell cortex during metaphase (PubMed:11781568, PubMed:15632202, PubMed:22074847). Colocalizes with NUMA1 to mitotic spindle poles (PubMed:11781568, PubMed:21816348). Localized at the central and lateral cell cortex regions in a RanGTP-dependent manner (PubMed:22327364). In horizontally retinal progenitor dividing cells, localized to the lateral cortical region. In vertically retinal progenitor dividing cells, localized at the polar cortical region (By similarity). {ECO:0000250|UniProtKB:Q8VDU0, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22074847, ECO:0000269|PubMed:22327364}.
P81277	reviewed	PRRP_HUMAN	Prolactin-releasing peptide (PrRP) (Prolactin-releasing hormone) [Cleaved into: Prolactin-releasing peptide PrRP31; Prolactin-releasing peptide PrRP20]	PRLH PRH	Homo sapiens (Human)	87	FUNCTION: Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.		autonomic nervous system development [GO:0048483]; eating behavior [GO:0042755]; energy reserve metabolic process [GO:0006112]; fat cell differentiation [GO:0045444]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; regulation of multicellular organism growth [GO:0040014]; response to dietary excess [GO:0002021]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; response to peptide hormone [GO:0043434]; tissue homeostasis [GO:0001894]	extracellular region [GO:0005576]	hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; prolactin-releasing peptide receptor binding [GO:0031861]	extracellular region [GO:0005576]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; prolactin-releasing peptide receptor binding [GO:0031861]; autonomic nervous system development [GO:0048483]; eating behavior [GO:0042755]; energy reserve metabolic process [GO:0006112]; fat cell differentiation [GO:0045444]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; regulation of multicellular organism growth [GO:0040014]; response to dietary excess [GO:0002021]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; response to peptide hormone [GO:0043434]; tissue homeostasis [GO:0001894]	SUBCELLULAR LOCATION: Secreted.
P81408	reviewed	EREP3_HUMAN	Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1)	ENTREP3 C1orf2 COTE1 FAM189B	Homo sapiens (Human)	668				membrane [GO:0016020]	WW domain binding [GO:0050699]	membrane [GO:0016020]; WW domain binding [GO:0050699]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P81534	reviewed	D103A_HUMAN	Beta-defensin 103 (Beta-defensin 3) (BD-3) (DEFB-3) (HBD3) (hBD-3) (Defensin, beta 103) (Defensin-like protein)	DEFB103A BD3 DEFB103 DEFB3; DEFB103B	Homo sapiens (Human)	67	FUNCTION: Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. {ECO:0000269|PubMed:11085990}.		cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]	CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]; cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]	SUBCELLULAR LOCATION: Secreted.
P81605	reviewed	DCD_HUMAN	Dermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1]	DCD AIDD DSEP	Homo sapiens (Human)	110	FUNCTION: [DCD-1]: Found in sweat, has an antimicrobial activity during early bacterial colonization (PubMed:11694882, PubMed:23426625). The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes (PubMed:23426625). Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival (PubMed:23426625). Highly effective against E.coli, E.faecalis, S.aureus and C.albicans (PubMed:11694882). Optimal pH and salt concentration resemble the conditions in sweat (PubMed:11694882). Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443). {ECO:0000269|PubMed:11694882, ECO:0000269|PubMed:17448443, ECO:0000269|PubMed:23426625}.; FUNCTION: [Survival-promoting peptide]: Promotes survival of neurons and displays phosphatase activity (PubMed:9736629). It may bind IgG (PubMed:9736629). {ECO:0000269|PubMed:9736629}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; killing by host of symbiont cells [GO:0051873]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]	lipid binding [GO:0008289]; metal ion binding [GO:0046872]; monoatomic ion channel activity [GO:0005216]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; monoatomic ion channel activity [GO:0005216]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; killing by host of symbiont cells [GO:0051873]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11694882, ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:25946035, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:9736629}.; SUBCELLULAR LOCATION: [Survival-promoting peptide]: Secreted {ECO:0000269|PubMed:9736629}.; SUBCELLULAR LOCATION: [DCD-1]: Secreted {ECO:0000305|PubMed:23426625}. Membrane {ECO:0000269|PubMed:23426625}; Peripheral membrane protein {ECO:0000269|PubMed:23426625}. Membrane {ECO:0000269|PubMed:23426625}; Single-pass membrane protein {ECO:0000269|PubMed:23426625}. Note=The secreted peptide assembles into homohexameric complexes that can probably associate with pathogen membranes and also insert into these membranes where they behave as channels. {ECO:0000269|PubMed:23426625}.
P82094	reviewed	TMF1_HUMAN	TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa)	TMF1 ARA160	Homo sapiens (Human)	1093	FUNCTION: Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}.		acrosome assembly [GO:0001675]; androgen receptor signaling pathway [GO:0030521]; defense response to bacterium [GO:0042742]; epithelial cell apoptotic process [GO:1904019]; flagellated sperm motility [GO:0030317]; Leydig cell differentiation [GO:0033327]; luteinizing hormone secretion [GO:0032275]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of gene expression [GO:0010629]; positive regulation of cytokine production [GO:0001819]; positive regulation of testosterone secretion [GO:2000845]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of proteasomal protein catabolic process [GO:0061136]; spermatid nucleus differentiation [GO:0007289]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]	DNA binding [GO:0003677]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; DNA binding [GO:0003677]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; acrosome assembly [GO:0001675]; androgen receptor signaling pathway [GO:0030521]; defense response to bacterium [GO:0042742]; epithelial cell apoptotic process [GO:1904019]; flagellated sperm motility [GO:0030317]; Leydig cell differentiation [GO:0033327]; luteinizing hormone secretion [GO:0032275]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of gene expression [GO:0010629]; positive regulation of cytokine production [GO:0001819]; positive regulation of testosterone secretion [GO:2000845]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of proteasomal protein catabolic process [GO:0061136]; spermatid nucleus differentiation [GO:0007289]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Golgi apparatus membrane. Note=Concentrated at the budding structures localized at the tips of cisternae.
P82251	reviewed	BAT1_HUMAN	b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)	SLC7A9 BAT1	Homo sapiens (Human)	487	FUNCTION: Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (PubMed:8663357, PubMed:16825196, PubMed:32817565, PubMed:32494597). Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (PubMed:8663357, PubMed:16825196, PubMed:32494597). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (PubMed:8663357). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules. {ECO:0000269|PubMed:10471498, ECO:0000269|PubMed:10588648, ECO:0000269|PubMed:16609684, ECO:0000269|PubMed:16825196, ECO:0000269|PubMed:32494597, ECO:0000269|PubMed:32817565, ECO:0000269|PubMed:8663357}.		amino acid transmembrane transport [GO:0003333]; L-cystine transport [GO:0015811]; neutral amino acid transport [GO:0015804]; protein-containing complex assembly [GO:0065003]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]	antiporter activity [GO:0015297]; broad specificity neutral L-amino acid:basic L-amino acid antiporter activity [GO:0180009]; L-cystine transmembrane transporter activity [GO:0015184]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; protein heterodimerization activity [GO:0046982]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; broad specificity neutral L-amino acid:basic L-amino acid antiporter activity [GO:0180009]; L-cystine transmembrane transporter activity [GO:0015184]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; protein heterodimerization activity [GO:0046982]; amino acid transmembrane transport [GO:0003333]; L-cystine transport [GO:0015811]; neutral amino acid transport [GO:0015804]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12167606, ECO:0000269|PubMed:16609684}; Multi-pass membrane protein {ECO:0000269|PubMed:16609684, ECO:0000305|PubMed:12167606}. Cell membrane {ECO:0000269|PubMed:16825196, ECO:0000269|PubMed:32817565}; Multi-pass membrane protein {ECO:0000255}.
P82279	reviewed	CRUM1_HUMAN	Protein crumbs homolog 1	CRB1	Homo sapiens (Human)	1406	FUNCTION: Plays a role in photoreceptor morphogenesis in the retina (By similarity). May maintain cell polarization and adhesion (By similarity). {ECO:0000250|UniProtKB:Q8VHS2}.		blood vessel remodeling [GO:0001974]; cell-cell signaling [GO:0007267]; cellular response to light stimulus [GO:0071482]; detection of light stimulus involved in visual perception [GO:0050908]; establishment of bipolar cell polarity involved in cell morphogenesis [GO:0061159]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; eye photoreceptor cell development [GO:0042462]; gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; plasma membrane organization [GO:0007009]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; protein localization [GO:0008104]; retina layer formation [GO:0010842]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; glial cell projection [GO:0097386]; microvillus [GO:0005902]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; subapical complex [GO:0035003]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; glial cell projection [GO:0097386]; microvillus [GO:0005902]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; subapical complex [GO:0035003]; calcium ion binding [GO:0005509]; blood vessel remodeling [GO:0001974]; cell-cell signaling [GO:0007267]; cellular response to light stimulus [GO:0071482]; detection of light stimulus involved in visual perception [GO:0050908]; establishment of bipolar cell polarity involved in cell morphogenesis [GO:0061159]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; eye photoreceptor cell development [GO:0042462]; gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; plasma membrane organization [GO:0007009]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; protein localization [GO:0008104]; retina layer formation [GO:0010842]	SUBCELLULAR LOCATION: [Isoform 1]: Apical cell membrane {ECO:0000250|UniProtKB:Q8VHS2}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000305}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q8VHS2}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8VHS2}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
P82650	reviewed	RT22_HUMAN	Small ribosomal subunit protein mS22 (28S ribosomal protein S22, mitochondrial) (MRP-S22) (S22mt)	MRPS22 C3orf5 RPMS22 GK002	Homo sapiens (Human)	360			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
P82914	reviewed	RT15_HUMAN	Small ribosomal subunit protein uS15m (28S ribosomal protein S15, mitochondrial) (MRP-S15) (S15mt)	MRPS15 RPMS15 DC37	Homo sapiens (Human)	257			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:27184847}.
P82930	reviewed	RT34_HUMAN	Small ribosomal subunit protein mS34 (28S ribosomal protein S34, mitochondrial) (MRP-S34) (S34mt)	MRPS34	Homo sapiens (Human)	218	FUNCTION: Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation. {ECO:0000269|PubMed:28777931}.		mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279123}.
P82932	reviewed	RT06_HUMAN	Small ribosomal subunit protein bS6m (28S ribosomal protein S6, mitochondrial) (MRP-S6) (S6mt)	MRPS6 C21orf101 RPMS6	Homo sapiens (Human)	125			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; small ribosomal subunit [GO:0015935]	small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; small ribosomal subunit [GO:0015935]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
P82979	reviewed	SARNP_HUMAN	SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29)	SARNP HCC1 HSPC316	Homo sapiens (Human)	210	FUNCTION: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015}.		mRNA export from nucleus [GO:0006406]; negative regulation of transcription by RNA polymerase II [GO:0000122]; poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of translation [GO:0006417]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex [GO:0000346]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; RNA binding [GO:0003723]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex [GO:0000346]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; negative regulation of transcription by RNA polymerase II [GO:0000122]; poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of translation [GO:0006417]	SUBCELLULAR LOCATION: Nucleus. Nucleus speckle.
P82987	reviewed	ATL3_HUMAN	ADAMTS-like protein 3 (ADAMTSL-3) (Punctin-2)	ADAMTSL3 KIAA1233	Homo sapiens (Human)	1691			extracellular matrix organization [GO:0030198]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]		extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:14667842}.
P83105	reviewed	HTRA4_HUMAN	Serine protease HTRA4 (EC 3.4.21.-) (High-temperature requirement factor A4)	HTRA4	Homo sapiens (Human)	476	FUNCTION: Serine protease. {ECO:0000305}.		negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of apoptotic process [GO:0043065]; programmed cell death [GO:0012501]; proteolysis [GO:0006508]	extracellular region [GO:0005576]	endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of apoptotic process [GO:0043065]; programmed cell death [GO:0012501]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
P83110	reviewed	HTRA3_HUMAN	Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease)	HTRA3 PRSP	Homo sapiens (Human)	453	FUNCTION: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724). {ECO:0000250|UniProtKB:Q9D236, ECO:0000269|PubMed:21321049, ECO:0000269|PubMed:22229724}.		negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; proteolysis [GO:0006508]	extracellular region [GO:0005576]	endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular region [GO:0005576]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21321049}. Note=Secretion increased during decidualization of endometrial stromal cells.
P83111	reviewed	LACTB_HUMAN	Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)	LACTB MRPL56 UNQ843/PRO1781	Homo sapiens (Human)	547	FUNCTION: Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758). {ECO:0000269|PubMed:28329758}.		lipid metabolic process [GO:0006629]; proteolysis [GO:0006508]; regulation of lipid metabolic process [GO:0019216]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	identical protein binding [GO:0042802]; peptidase activity [GO:0008233]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; lipid metabolic process [GO:0006629]; proteolysis [GO:0006508]; regulation of lipid metabolic process [GO:0019216]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11551941, ECO:0000269|PubMed:19858488, ECO:0000269|PubMed:28329758}.
P83369	reviewed	LSM11_HUMAN	U7 snRNA-associated Sm-like protein LSm11	LSM11	Homo sapiens (Human)	360	FUNCTION: Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed:11574479, PubMed:16914750, PubMed:33230297). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed:11574479, PubMed:16914750). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to the Sm-binding site of U7 snRNA (PubMed:11574479, PubMed:16914750). {ECO:0000250|UniProtKB:Q8BUV6, ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:16914750, ECO:0000269|PubMed:33230297}.		mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; regulation of chromatin organization [GO:1902275]	histone pre-mRNA 3'end processing complex [GO:0071204]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]; U7 snRNP [GO:0005683]	U7 snRNA binding [GO:0071209]	histone pre-mRNA 3'end processing complex [GO:0071204]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]; U7 snRNP [GO:0005683]; U7 snRNA binding [GO:0071209]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; regulation of chromatin organization [GO:1902275]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12975319}.
P83436	reviewed	COG7_HUMAN	Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7)	COG7 UNQ3082/PRO10013	Homo sapiens (Human)	770	FUNCTION: Required for normal Golgi function. {ECO:0000269|PubMed:11980916}.		glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein glycosylation [GO:0006486]; protein localization to Golgi apparatus [GO:0034067]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; trans-Golgi network membrane [GO:0032588]		Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; trans-Golgi network membrane [GO:0032588]; glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein glycosylation [GO:0006486]; protein localization to Golgi apparatus [GO:0034067]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11980916}; Peripheral membrane protein {ECO:0000269|PubMed:11980916}.
P83731	reviewed	RL24_HUMAN	Large ribosomal subunit protein eL24 (60S ribosomal protein L24) (60S ribosomal protein L30)	RPL24	Homo sapiens (Human)	157	FUNCTION: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; exit from mitosis [GO:0010458]; optic nerve development [GO:0021554]; retina development in camera-type eye [GO:0060041]; retinal ganglion cell axon guidance [GO:0031290]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; synapse [GO:0045202]	cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; synapse [GO:0045202]; cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; exit from mitosis [GO:0010458]; optic nerve development [GO:0021554]; retina development in camera-type eye [GO:0060041]; retinal ganglion cell axon guidance [GO:0031290]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P83876	reviewed	TXN4A_HUMAN	Thioredoxin-like protein 4A (DIM1 protein homolog) (Spliceosomal U5 snRNP-specific 15 kDa protein) (Thioredoxin-like U5 snRNP protein U5-15kD)	TXNL4A DIM1 TXNL4	Homo sapiens (Human)	142	FUNCTION: Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:28781166, ECO:0000305|PubMed:10610776, ECO:0000305|PubMed:26912367}.		cell cycle [GO:0007049]; cell division [GO:0051301]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; cell cycle [GO:0007049]; cell division [GO:0051301]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10610776, ECO:0000269|PubMed:11054566, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
P83881	reviewed	RL36A_HUMAN	Large ribosomal subunit protein eL42 (60S ribosomal protein L36a) (60S ribosomal protein L44) (Cell growth-inhibiting gene 15 protein) (Cell migration-inducing gene 6 protein)	RPL36A RPL44 GIG15 MIG6	Homo sapiens (Human)	106	FUNCTION: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; polysomal ribosome [GO:0042788]; ribosome [GO:0005840]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; polysomal ribosome [GO:0042788]; ribosome [GO:0005840]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P83916	reviewed	CBX1_HUMAN	Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)	CBX1 CBX	Homo sapiens (Human)	185	FUNCTION: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. {ECO:0000250|UniProtKB:P83917}.		chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; negative regulation of transcription by RNA polymerase II [GO:0000122]	chromatin [GO:0000785]; chromocenter [GO:0010369]; chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; female pronucleus [GO:0001939]; heterochromatin [GO:0000792]; intracellular membrane-bounded organelle [GO:0043231]; male pronucleus [GO:0001940]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of DNA damage [GO:0090734]; spindle [GO:0005819]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; molecular adaptor activity [GO:0060090]	chromatin [GO:0000785]; chromocenter [GO:0010369]; chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; female pronucleus [GO:0001939]; heterochromatin [GO:0000792]; intracellular membrane-bounded organelle [GO:0043231]; male pronucleus [GO:0001940]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of DNA damage [GO:0090734]; spindle [GO:0005819]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; molecular adaptor activity [GO:0060090]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9169582}. Note=Unassociated with chromosomes during mitosis.
P84022	reviewed	SMAD3_HUMAN	Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)	SMAD3 MADH3	Homo sapiens (Human)	425	FUNCTION: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:15588252, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9732876, ECO:0000269|PubMed:9892009}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cell-cell junction organization [GO:0045216]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to virus [GO:0098586]; developmental growth [GO:0048589]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic foregut morphogenesis [GO:0048617]; embryonic pattern specification [GO:0009880]; endoderm development [GO:0007492]; extrinsic apoptotic signaling pathway [GO:0097191]; heart looping [GO:0001947]; immune response [GO:0006955]; immune system development [GO:0002520]; in utero embryonic development [GO:0001701]; JNK cascade [GO:0007254]; lens fiber cell differentiation [GO:0070306]; liver development [GO:0001889]; mesoderm formation [GO:0001707]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lung blood pressure [GO:0061767]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of wound healing [GO:0061045]; nodal signaling pathway [GO:0038092]; osteoblast development [GO:0002076]; paraxial mesoderm morphogenesis [GO:0048340]; pericardium development [GO:0060039]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta3 production [GO:0032916]; primary miRNA processing [GO:0031053]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation [GO:0050678]; regulation of immune response [GO:0050776]; regulation of miRNA transcription [GO:1902893]; regulation of striated muscle tissue development [GO:0016202]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein signal transduction [GO:0060395]; somitogenesis [GO:0001756]; T cell activation [GO:0042110]; thyroid gland development [GO:0030878]; transdifferentiation [GO:0060290]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; wound healing [GO:0042060]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; SMAD protein complex [GO:0071141]; transcription regulator complex [GO:0005667]	beta-catenin binding [GO:0008013]; bHLH transcription factor binding [GO:0043425]; chromatin DNA binding [GO:0031490]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; co-SMAD binding [GO:0070410]; collagen binding [GO:0005518]; DEAD/H-box RNA helicase binding [GO:0017151]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear mineralocorticoid receptor binding [GO:0031962]; nuclear receptor binding [GO:0016922]; phosphatase binding [GO:0019902]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sterol response element binding [GO:0032810]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; SMAD protein complex [GO:0071141]; transcription regulator complex [GO:0005667]; beta-catenin binding [GO:0008013]; bHLH transcription factor binding [GO:0043425]; chromatin DNA binding [GO:0031490]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; co-SMAD binding [GO:0070410]; collagen binding [GO:0005518]; DEAD/H-box RNA helicase binding [GO:0017151]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear mineralocorticoid receptor binding [GO:0031962]; nuclear receptor binding [GO:0016922]; phosphatase binding [GO:0019902]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sterol response element binding [GO:0032810]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cell-cell junction organization [GO:0045216]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to virus [GO:0098586]; developmental growth [GO:0048589]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic foregut morphogenesis [GO:0048617]; embryonic pattern specification [GO:0009880]; endoderm development [GO:0007492]; extrinsic apoptotic signaling pathway [GO:0097191]; heart looping [GO:0001947]; immune response [GO:0006955]; immune system development [GO:0002520]; in utero embryonic development [GO:0001701]; JNK cascade [GO:0007254]; lens fiber cell differentiation [GO:0070306]; liver development [GO:0001889]; mesoderm formation [GO:0001707]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lung blood pressure [GO:0061767]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of wound healing [GO:0061045]; nodal signaling pathway [GO:0038092]; osteoblast development [GO:0002076]; paraxial mesoderm morphogenesis [GO:0048340]; pericardium development [GO:0060039]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta3 production [GO:0032916]; primary miRNA processing [GO:0031053]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation [GO:0050678]; regulation of immune response [GO:0050776]; regulation of miRNA transcription [GO:1902893]; regulation of striated muscle tissue development [GO:0016202]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein signal transduction [GO:0060395]; somitogenesis [GO:0001756]; T cell activation [GO:0042110]; thyroid gland development [GO:0030878]; transdifferentiation [GO:0060290]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:22781750}. Nucleus {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:22781750}. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969, PubMed:21145499). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15601644). MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity). {ECO:0000250|UniProtKB:Q8BUN5, ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:21145499}.
P84074	reviewed	HPCA_HUMAN	Neuron-specific calcium-binding protein hippocalcin (Calcium-binding protein BDR-2)	HPCA BDR2	Homo sapiens (Human)	193	FUNCTION: Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity). {ECO:0000250|UniProtKB:P84076, ECO:0000269|PubMed:28398555}.		calcium-mediated signaling [GO:0019722]; cellular response to calcium ion [GO:0071277]; cellular response to electrical stimulus [GO:0071257]; cellular response to L-glutamate [GO:1905232]; inner ear development [GO:0048839]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of voltage-gated calcium channel activity [GO:1901385]; response to Aroclor 1254 [GO:1904010]; response to ketamine [GO:1901986]; retina development in camera-type eye [GO:0060041]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dendrite membrane [GO:0032590]; dendritic spine head [GO:0044327]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]	actin binding [GO:0003779]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dendrite membrane [GO:0032590]; dendritic spine head [GO:0044327]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; actin binding [GO:0003779]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; calcium-mediated signaling [GO:0019722]; cellular response to calcium ion [GO:0071277]; cellular response to electrical stimulus [GO:0071257]; cellular response to L-glutamate [GO:1905232]; inner ear development [GO:0048839]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of voltage-gated calcium channel activity [GO:1901385]; response to Aroclor 1254 [GO:1904010]; response to ketamine [GO:1901986]; retina development in camera-type eye [GO:0060041]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P84076, ECO:0000269|PubMed:28398555}. Membrane {ECO:0000250|UniProtKB:P84076}; Peripheral membrane protein {ECO:0000250|UniProtKB:P84076}. Note=Association with membranes is calcium-dependent (By similarity). Enriched in the perinuclear region, probably at the trans Golgi network in response to calcium (PubMed:28398555). {ECO:0000250|UniProtKB:P84076, ECO:0000269|PubMed:28398555}.
P84077	reviewed	ARF1_HUMAN	ADP-ribosylation factor 1 (EC 3.6.5.2)	ARF1	Homo sapiens (Human)	181	FUNCTION: Small GTPase involved in protein trafficking between different compartments (PubMed:8253837). Modulates vesicle budding and uncoating within the Golgi complex (PubMed:8253837). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (PubMed:8253837). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (PubMed:8253837). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). {ECO:0000250|UniProtKB:P84079, ECO:0000269|PubMed:8253837}.; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}.		cellular response to virus [GO:0098586]; dendritic spine organization [GO:0097061]; intracellular copper ion homeostasis [GO:0006878]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; mitotic cleavage furrow ingression [GO:1990386]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of receptor internalization [GO:0002090]; vesicle-mediated transport [GO:0016192]	cell leading edge [GO:0031252]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]	cell leading edge [GO:0031252]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; cellular response to virus [GO:0098586]; dendritic spine organization [GO:0097061]; intracellular copper ion homeostasis [GO:0006878]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; mitotic cleavage furrow ingression [GO:1990386]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of receptor internalization [GO:0002090]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17555535}; Lipid-anchor {ECO:0000269|PubMed:17555535}; Cytoplasmic side {ECO:0000305}. Synapse, synaptosome {ECO:0000250|UniProtKB:P84079}. Postsynaptic density {ECO:0000250|UniProtKB:P84079}. Note=In the GDP-bound form, associates transiently with the membranes via its myristoylated N-terminus where guanine nucleotide-exchange factor (GEF)-mediated nucleotide exchange occurs (By similarity). Following nucleotide exchange, the GTP-bound form undergoes a conformational change, leading to the exposure of a myristoylated N-terminal amphipathic helix that provides stable membrane anchorage (By similarity). {ECO:0000250|UniProtKB:P84080}.
P84085	reviewed	ARF5_HUMAN	ADP-ribosylation factor 5	ARF5	Homo sapiens (Human)	180	FUNCTION: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. {ECO:0000250|UniProtKB:P84084}.; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}.		intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:17555535}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17555535}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P84084}; Lipid-anchor {ECO:0000250|UniProtKB:P84084}.
P84090	reviewed	ERH_HUMAN	Enhancer of rudimentary homolog	ERH	Homo sapiens (Human)	104	FUNCTION: May have a role in the cell cycle.		cell cycle [GO:0007049]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleoside metabolic process [GO:0006213]	methylosome [GO:0034709]; midbody [GO:0030496]; nucleus [GO:0005634]	methyl-CpG binding [GO:0008327]; RNA binding [GO:0003723]	methylosome [GO:0034709]; midbody [GO:0030496]; nucleus [GO:0005634]; methyl-CpG binding [GO:0008327]; RNA binding [GO:0003723]; cell cycle [GO:0007049]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleoside metabolic process [GO:0006213]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23145069}.
P84095	reviewed	RHOG_HUMAN	Rho-related GTP-binding protein RhoG	RHOG ARHG	Homo sapiens (Human)	191	FUNCTION: Plays a role in immunological synaptic F-actin density and architecture organization (PubMed:33513601). Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity (PubMed:33513601). Required for the formation of membrane ruffles during macropinocytosis (PubMed:15133129). Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (PubMed:17875742). Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) (PubMed:33513601). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells (PubMed:33513601). Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D (PubMed:33513601). Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells (PubMed:33513601). {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:33513601}.; FUNCTION: (Microbial infection) In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:17074883}.		actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; cortical cytoskeleton organization [GO:0030865]; establishment or maintenance of cell polarity [GO:0007163]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to plasma membrane [GO:1903078]; Rac protein signal transduction [GO:0016601]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of ruffle assembly [GO:1900027]; Rho protein signal transduction [GO:0007266]	cell projection [GO:0042995]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]	cell projection [GO:0042995]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; cortical cytoskeleton organization [GO:0030865]; establishment or maintenance of cell polarity [GO:0007163]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to plasma membrane [GO:1903078]; Rac protein signal transduction [GO:0016601]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of ruffle assembly [GO:1900027]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P84098	reviewed	RL19_HUMAN	Large ribosomal subunit protein eL19 (60S ribosomal protein L19)	RPL19	Homo sapiens (Human)	196	FUNCTION: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; polysomal ribosome [GO:0042788]; synapse [GO:0045202]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; polysomal ribosome [GO:0042788]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
P84103	reviewed	SRSF3_HUMAN	Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)	SRSF3 SFRS3 SRP20	Homo sapiens (Human)	164	FUNCTION: Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). RNA-binding is semi-sequence specific (PubMed:17036044). {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:28984244}.		cellular response to leukemia inhibitory factor [GO:1990830]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; primary miRNA processing [GO:0031053]; regulation of mRNA splicing, via spliceosome [GO:0048024]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	phospholipase binding [GO:0043274]; primary miRNA binding [GO:0070878]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; phospholipase binding [GO:0043274]; primary miRNA binding [GO:0070878]; RNA binding [GO:0003723]; cellular response to leukemia inhibitory factor [GO:1990830]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; primary miRNA processing [GO:0031053]; regulation of mRNA splicing, via spliceosome [GO:0048024]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11336712}. Nucleus speckle {ECO:0000269|PubMed:26876937}. Cytoplasm {ECO:0000269|PubMed:11336712}. Note=Recruited to nuclear speckles following interaction with YTHDC1. {ECO:0000269|PubMed:26876937}.
P84243	reviewed	H33_HUMAN	Histone H3.3	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	Homo sapiens (Human)	136	FUNCTION: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}.		cell population proliferation [GO:0008283]; embryo implantation [GO:0007566]; male gonad development [GO:0008584]; multicellular organism growth [GO:0035264]; muscle cell differentiation [GO:0042692]; negative regulation of chromosome condensation [GO:1902340]; nucleosome assembly [GO:0006334]; nucleus organization [GO:0006997]; oocyte maturation [GO:0001556]; osteoblast differentiation [GO:0001649]; pericentric heterochromatin formation [GO:0031508]; positive regulation of cell growth [GO:0030307]; regulation of centromere complex assembly [GO:0090230]; single fertilization [GO:0007338]; spermatid development [GO:0007286]; subtelomeric heterochromatin formation [GO:0031509]; telomere organization [GO:0032200]	Barr body [GO:0001740]; chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	nucleosomal DNA binding [GO:0031492]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; structural constituent of chromatin [GO:0030527]	Barr body [GO:0001740]; chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; nucleosomal DNA binding [GO:0031492]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; structural constituent of chromatin [GO:0030527]; cell population proliferation [GO:0008283]; embryo implantation [GO:0007566]; male gonad development [GO:0008584]; multicellular organism growth [GO:0035264]; muscle cell differentiation [GO:0042692]; negative regulation of chromosome condensation [GO:1902340]; nucleosome assembly [GO:0006334]; nucleus organization [GO:0006997]; oocyte maturation [GO:0001556]; osteoblast differentiation [GO:0001649]; pericentric heterochromatin formation [GO:0031508]; positive regulation of cell growth [GO:0030307]; regulation of centromere complex assembly [GO:0090230]; single fertilization [GO:0007338]; spermatid development [GO:0007286]; subtelomeric heterochromatin formation [GO:0031509]; telomere organization [GO:0032200]	SUBCELLULAR LOCATION: Nucleus. Chromosome {ECO:0000269|PubMed:34876591}.
P84550	reviewed	SKOR1_HUMAN	SKI family transcriptional corepressor 1 (Functional Smad-suppressing element on chromosome 15) (Fussel-15) (LBX1 corepressor 1) (Ladybird homeobox corepressor 1)	SKOR1 CORL1 FUSSEL15 LBXCOR1	Homo sapiens (Human)	965	FUNCTION: Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling. {ECO:0000250}.		negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]	dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P84996	reviewed	ALEX_HUMAN	Protein ALEX (Alternative gene product encoded by XL-exon)	GNAS GNAS1	Homo sapiens (Human)	626	FUNCTION: May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame. {ECO:0000269|PubMed:12719376}.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces guanine nucleotide-binding protein G(s) subunit alpha from an overlapping reading frame. {ECO:0000269|PubMed:15148396}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone development [GO:0060348]; cognition [GO:0050890]; developmental growth [GO:0048589]; hair follicle placode formation [GO:0060789]; platelet aggregation [GO:0070527]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of signal transduction [GO:0009966]	cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle [GO:0001726]		cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone development [GO:0060348]; cognition [GO:0050890]; developmental growth [GO:0048589]; hair follicle placode formation [GO:0060789]; platelet aggregation [GO:0070527]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell projection, ruffle {ECO:0000250}. Note=Predominantly associated with cell membrane ruffles. {ECO:0000250}.
P85037	reviewed	FOXK1_HUMAN	Forkhead box protein K1 (Myocyte nuclear factor) (MNF)	FOXK1 MNF	Homo sapiens (Human)	733	FUNCTION: Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164}.		canonical glycolysis [GO:0061621]; cell differentiation [GO:0030154]; intracellular glucose homeostasis [GO:0001678]; muscle organ development [GO:0007517]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription by RNA polymerase II [GO:0006357]; response to starvation [GO:0042594]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	14-3-3 protein binding [GO:0071889]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 14-3-3 protein binding [GO:0071889]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; canonical glycolysis [GO:0061621]; cell differentiation [GO:0030154]; intracellular glucose homeostasis [GO:0001678]; muscle organ development [GO:0007517]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription by RNA polymerase II [GO:0006357]; response to starvation [GO:0042594]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164}. Cytoplasm {ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164}. Note=Translocation to the nucleus is regulated by phosphorylation: phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with 14-3-3 proteins and sequestration in the cytoplasm. Dephosphorylation promotes translocation to the nucleus (By similarity). Accumulates in the nucleus upon viral infection (PubMed:25852164). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:25852164}.
P85298	reviewed	RHG08_HUMAN	Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8)	ARHGAP8	Homo sapiens (Human)	464	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.		negative regulation of endocytic recycling [GO:2001136]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; negative regulation of endocytic recycling [GO:2001136]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	
P85299	reviewed	PRR5_HUMAN	Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1)	PRR5 PROTOR1 PP610	Homo sapiens (Human)	388	FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17599906}.		cell cycle [GO:0007049]; cellular response to nutrient levels [GO:0031669]; cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell growth [GO:0030307]; positive regulation of protein phosphorylation [GO:0001934]; TORC2 signaling [GO:0038203]	cytosol [GO:0005829]; TORC2 complex [GO:0031932]		cytosol [GO:0005829]; TORC2 complex [GO:0031932]; cell cycle [GO:0007049]; cellular response to nutrient levels [GO:0031669]; cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell growth [GO:0030307]; positive regulation of protein phosphorylation [GO:0001934]; TORC2 signaling [GO:0038203]	
P86397	reviewed	HTD2_HUMAN	Hydroxyacyl-thioester dehydratase type 2, mitochondrial (HsHTD2) (EC 4.2.1.59) (3-hydroxyacyl-[acyl-carrier-protein] dehydratase)	HTD2	Homo sapiens (Human)	168	FUNCTION: Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis. {ECO:0000269|PubMed:17898086}.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the RPP14 protein from an overlapping reading frame. {ECO:0000269|PubMed:17898086}.	fatty acid biosynthetic process [GO:0006633]; fatty-acyl-CoA biosynthetic process [GO:0046949]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity [GO:0008693]; (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [GO:0019171]; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity [GO:0008659]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity [GO:0008693]; (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [GO:0019171]; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity [GO:0008659]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; fatty acid biosynthetic process [GO:0006633]; fatty-acyl-CoA biosynthetic process [GO:0046949]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:17898086}.
P86452	reviewed	ZBED6_HUMAN	Zinc finger BED domain-containing protein 6	ZBED6	Homo sapiens (Human)	979	FUNCTION: Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (By similarity). Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (By similarity). Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (By similarity). Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (By similarity). Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (By similarity). Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816). Binds to the CDH2 gene and may directly repress CDH2 transcription (By similarity). Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (By similarity). May also play a role in embryonic beta cell differentiation (By similarity). May play a role in insulin sensitivity and glucose clearance (By similarity). {ECO:0000250|UniProtKB:D2EAC2, ECO:0000269|PubMed:24043816}.	MISCELLANEOUS: Encoded by an exapted DNA transposon located in an intron of the ZC3H11A gene. {ECO:0000269|PubMed:20016685}.	blastocyst hatching [GO:0001835]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of transcription by RNA polymerase II [GO:0006357]	centriolar satellite [GO:0034451]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; transcription cis-regulatory region binding [GO:0000976]	centriolar satellite [GO:0034451]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; transcription cis-regulatory region binding [GO:0000976]; blastocyst hatching [GO:0001835]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24043816}. Nucleus, nucleolus {ECO:0000250|UniProtKB:D2EAC2}. Cytoplasm {ECO:0000269|PubMed:24043816}. Note=Located predominantly in the nucleolus but is also dispersed throughout the nucleus (By similarity). Mainly cytoplasmic in insulin- and glucagon-positive islet pancreatic cells, however nuclear localization is evidence in some pancreatic endocrine cells (PubMed:24043816). {ECO:0000250|UniProtKB:D2EAC2, ECO:0000269|PubMed:24043816}.
P86479	reviewed	PR20C_HUMAN	Proline-rich protein 20C	PRR20C	Homo sapiens (Human)	221							
P86480	reviewed	PR20D_HUMAN	Proline-rich protein 20D	PRR20D	Homo sapiens (Human)	221					identical protein binding [GO:0042802]	identical protein binding [GO:0042802]	
P98066	reviewed	TSG6_HUMAN	Tumor necrosis factor-inducible gene 6 protein (EC 3.1.1.-) (Hyaluronate-binding protein) (TNF-stimulated gene 6 protein) (TSG-6) (Tumor necrosis factor alpha-induced protein 6) (TNF alpha-induced protein 6)	TNFAIP6 TSG6	Homo sapiens (Human)	277	FUNCTION: Major regulator of extracellular matrix organization during tissue remodeling (PubMed:18042364, PubMed:26823460, PubMed:15917224). Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin (PubMed:20463016, PubMed:15917224, PubMed:16873769). Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization (PubMed:26468290). Assembles hyaluronan in pericellular matrices that serve as platforms for receptor clustering and signaling. Enables binding of hyaluronan deposited on the surface of macrophages to LYVE1 on lymphatic endothelium and facilitates macrophage extravasation. Alters hyaluronan binding to functionally latent CD44 on vascular endothelium, switching CD44 into an active state that supports leukocyte rolling (PubMed:26823460, PubMed:15060082). Modulates the interaction of chemokines with extracellular matrix components and proteoglycans on endothelial cell surface, likely preventing chemokine gradient formation (PubMed:27044744). In a negative feedback mechanism, may limit excessive neutrophil recruitment at inflammatory sites by antagonizing the association of CXCL8 with glycosaminoglycans on vascular endothelium (PubMed:24501198). Has a role in osteogenesis and bone remodeling. Inhibits BMP2-dependent differentiation of mesenchymal stem cell to osteoblasts (PubMed:18586671, PubMed:16771708). Protects against bone erosion during inflammation by inhibiting TNFSF11/RANKL-dependent osteoclast activation (PubMed:18586671). {ECO:0000269|PubMed:15060082, ECO:0000269|PubMed:15917224, ECO:0000269|PubMed:16771708, ECO:0000269|PubMed:16873769, ECO:0000269|PubMed:18042364, ECO:0000269|PubMed:18586671, ECO:0000269|PubMed:20463016, ECO:0000269|PubMed:24501198, ECO:0000269|PubMed:26468290, ECO:0000269|PubMed:26823460, ECO:0000269|PubMed:27044744}.		cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; fibronectin fibril organization [GO:1905590]; hyaluronan metabolic process [GO:0030212]; inflammatory response [GO:0006954]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoclast differentiation [GO:0045671]; ovarian cumulus expansion [GO:0001550]; positive regulation of cell migration [GO:0030335]; positive regulation of receptor clustering [GO:1903911]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724]	calcium ion binding [GO:0005509]; carboxylesterase activity [GO:0106435]; fibronectin binding [GO:0001968]; hyaluronic acid binding [GO:0005540]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724]; calcium ion binding [GO:0005509]; carboxylesterase activity [GO:0106435]; fibronectin binding [GO:0001968]; hyaluronic acid binding [GO:0005540]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; fibronectin fibril organization [GO:1905590]; hyaluronan metabolic process [GO:0030212]; inflammatory response [GO:0006954]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoclast differentiation [GO:0045671]; ovarian cumulus expansion [GO:0001550]; positive regulation of cell migration [GO:0030335]; positive regulation of receptor clustering [GO:1903911]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1730767}.
P98073	reviewed	ENTK_HUMAN	Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain]	TMPRSS15 ENTK PRSS7	Homo sapiens (Human)	1019	FUNCTION: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.		proteolysis [GO:0006508]	brush border [GO:0005903]; membrane [GO:0016020]	serine-type endopeptidase activity [GO:0004252]	brush border [GO:0005903]; membrane [GO:0016020]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
P98077	reviewed	SHC2_HUMAN	SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2)	SHC2 SCK SHCB	Homo sapiens (Human)	582	FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity). {ECO:0000250}.	MISCELLANEOUS: PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.	intracellular signal transduction [GO:0035556]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	receptor tyrosine kinase binding [GO:0030971]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; receptor tyrosine kinase binding [GO:0030971]; intracellular signal transduction [GO:0035556]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	
P98082	reviewed	DAB2_HUMAN	Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)	DAB2 DOC2	Homo sapiens (Human)	770	FUNCTION: Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}.		apoptotic process [GO:0006915]; cellular response to epidermal growth factor stimulus [GO:0071364]; clathrin coat assembly [GO:0048268]; leading edge cell differentiation [GO:0035026]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein binding [GO:0032091]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of cell migration [GO:0030335]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of endocytosis [GO:0045807]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; response to salt [GO:1902074]; response to steroid hormone [GO:0048545]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway [GO:0016055]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cargo receptor activity [GO:0038024]; clathrin adaptor activity [GO:0035615]; low-density lipoprotein particle receptor binding [GO:0050750]; SMAD binding [GO:0046332]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cargo receptor activity [GO:0038024]; clathrin adaptor activity [GO:0035615]; low-density lipoprotein particle receptor binding [GO:0050750]; SMAD binding [GO:0046332]; apoptotic process [GO:0006915]; cellular response to epidermal growth factor stimulus [GO:0071364]; clathrin coat assembly [GO:0048268]; leading edge cell differentiation [GO:0035026]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein binding [GO:0032091]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of cell migration [GO:0030335]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of endocytosis [GO:0045807]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; response to salt [GO:1902074]; response to steroid hormone [GO:0048545]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, clathrin-coated pit. Note=Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is progressively displaced from the membrane and translocated to the cytoplasm.
P98088	reviewed	MUC5A_HUMAN	Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM)	MUC5AC MUC5	Homo sapiens (Human)	5654	FUNCTION: Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). {ECO:0000269|PubMed:14535999, ECO:0000303|PubMed:14535999, ECO:0000303|PubMed:14718370}.			extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; mucus layer [GO:0070701]; plasma membrane [GO:0005886]	extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; mucus layer [GO:0070701]; plasma membrane [GO:0005886]; extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14718370, ECO:0000269|PubMed:31732694}.
P98095	reviewed	FBLN2_HUMAN	Fibulin-2 (FIBL-2)	FBLN2	Homo sapiens (Human)	1184	FUNCTION: Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108). {ECO:0000269|PubMed:17255108}.		positive regulation of cell-substrate adhesion [GO:0010811]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]	calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; positive regulation of cell-substrate adhesion [GO:0010811]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
P98153	reviewed	IDD_HUMAN	Integral membrane protein DGCR2/IDD	DGCR2 IDD KIAA0163	Homo sapiens (Human)	550	FUNCTION: Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.		animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; cognition [GO:0050890]	membrane [GO:0016020]	carbohydrate binding [GO:0030246]	membrane [GO:0016020]; carbohydrate binding [GO:0030246]; animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; cognition [GO:0050890]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P98155	reviewed	VLDLR_HUMAN	Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R)	VLDLR	Homo sapiens (Human)	873	FUNCTION: Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU (PubMed:24381170, PubMed:30873003). In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 (PubMed:30873003). Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (PubMed:30873003). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity). {ECO:0000250|UniProtKB:P98156, ECO:0000269|PubMed:24381170, ECO:0000269|PubMed:30873003}.; FUNCTION: (Microbial infection) Acts as a receptor for Semliki Forest virus. {ECO:0000269|PubMed:34929721}.		cholesterol metabolic process [GO:0008203]; dendrite morphogenesis [GO:0048813]; glycoprotein transport [GO:0034436]; lipid transport [GO:0006869]; memory [GO:0007613]; nervous system development [GO:0007399]; positive regulation of dendrite development [GO:1900006]; receptor-mediated endocytosis [GO:0006898]; reelin-mediated signaling pathway [GO:0038026]; signal transduction [GO:0007165]; ventral spinal cord development [GO:0021517]; very-low-density lipoprotein particle clearance [GO:0034447]	clathrin-coated pit [GO:0005905]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; very-low-density lipoprotein particle [GO:0034361]	apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; cargo receptor activity [GO:0038024]; low-density lipoprotein particle receptor activity [GO:0005041]; reelin receptor activity [GO:0038025]; very-low-density lipoprotein particle binding [GO:0034189]; very-low-density lipoprotein particle receptor activity [GO:0030229]	clathrin-coated pit [GO:0005905]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; very-low-density lipoprotein particle [GO:0034361]; apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; cargo receptor activity [GO:0038024]; low-density lipoprotein particle receptor activity [GO:0005041]; reelin receptor activity [GO:0038025]; very-low-density lipoprotein particle binding [GO:0034189]; very-low-density lipoprotein particle receptor activity [GO:0030229]; cholesterol metabolic process [GO:0008203]; dendrite morphogenesis [GO:0048813]; glycoprotein transport [GO:0034436]; lipid transport [GO:0006869]; memory [GO:0007613]; nervous system development [GO:0007399]; positive regulation of dendrite development [GO:1900006]; receptor-mediated endocytosis [GO:0006898]; reelin-mediated signaling pathway [GO:0038026]; signal transduction [GO:0007165]; ventral spinal cord development [GO:0021517]; very-low-density lipoprotein particle clearance [GO:0034447]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23701949, ECO:0000269|PubMed:34929721}; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.
P98160	reviewed	PGBM_HUMAN	Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide]	HSPG2	Homo sapiens (Human)	4391	FUNCTION: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; FUNCTION: [Endorepellin]: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; FUNCTION: [LG3 peptide]: Has anti-angiogenic properties that require binding of calcium ions for full activity.	MISCELLANEOUS: [LG3 peptide]: Has been found in the urine of patients with end-stage renal disease and in the amniotic fluid of pregnant women with premature rupture of fetal membranes.	angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; brain development [GO:0007420]; cell differentiation [GO:0030154]; circulatory system development [GO:0072359]; embryo implantation [GO:0007566]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of endothelial cell proliferation [GO:0001938]; receptor-mediated endocytosis [GO:0006898]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; smoothened signaling pathway [GO:0007224]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]	amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; collagen V binding [GO:0070052]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; low-density lipoprotein particle receptor binding [GO:0050750]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; collagen V binding [GO:0070052]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; low-density lipoprotein particle receptor binding [GO:0050750]; angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; brain development [GO:0007420]; cell differentiation [GO:0030154]; circulatory system development [GO:0072359]; embryo implantation [GO:0007566]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of endothelial cell proliferation [GO:0001938]; receptor-mediated endocytosis [GO:0006898]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313}.
P98161	reviewed	PKD1_HUMAN	Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein)	PKD1	Homo sapiens (Human)	4303	FUNCTION: Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Both PKD1 and PKD2 are required for channel activity (PubMed:27214281). Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. {ECO:0000250|UniProtKB:O08852, ECO:0000269|PubMed:12482949, ECO:0000269|PubMed:27214281}.		anatomical structure morphogenesis [GO:0009653]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-independent cell-matrix adhesion [GO:0007161]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell-cell signaling by wnt [GO:0198738]; cell-matrix adhesion [GO:0007160]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; digestive tract development [GO:0048565]; embryonic placenta development [GO:0001892]; establishment of epithelial cell polarity [GO:0090162]; genitalia development [GO:0048806]; heart development [GO:0007507]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; liver development [GO:0001889]; lung epithelium development [GO:0060428]; lymph vessel morphogenesis [GO:0036303]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric collecting duct development [GO:0072205]; metanephric distal tubule morphogenesis [GO:0072287]; metanephric proximal tubule development [GO:0072237]; neural tube development [GO:0021915]; peptidyl-serine phosphorylation [GO:0018105]; placenta blood vessel development [GO:0060674]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein export from nucleus [GO:0006611]; protein heterotetramerization [GO:0051290]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic spindle organization [GO:0060236]; regulation of proteasomal protein catabolic process [GO:0061136]; response to fluid shear stress [GO:0034405]; skin development [GO:0043588]; spinal cord development [GO:0021510]	basolateral plasma membrane [GO:0016323]; calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; motile cilium [GO:0031514]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polycystin complex [GO:0002133]	calcium channel activity [GO:0005262]; carbohydrate binding [GO:0030246]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]; Wnt receptor activity [GO:0042813]	basolateral plasma membrane [GO:0016323]; calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; motile cilium [GO:0031514]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polycystin complex [GO:0002133]; calcium channel activity [GO:0005262]; carbohydrate binding [GO:0030246]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]; Wnt receptor activity [GO:0042813]; anatomical structure morphogenesis [GO:0009653]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-independent cell-matrix adhesion [GO:0007161]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell-cell signaling by wnt [GO:0198738]; cell-matrix adhesion [GO:0007160]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; digestive tract development [GO:0048565]; embryonic placenta development [GO:0001892]; establishment of epithelial cell polarity [GO:0090162]; genitalia development [GO:0048806]; heart development [GO:0007507]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; liver development [GO:0001889]; lung epithelium development [GO:0060428]; lymph vessel morphogenesis [GO:0036303]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric collecting duct development [GO:0072205]; metanephric distal tubule morphogenesis [GO:0072287]; metanephric proximal tubule development [GO:0072237]; neural tube development [GO:0021915]; peptidyl-serine phosphorylation [GO:0018105]; placenta blood vessel development [GO:0060674]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein export from nucleus [GO:0006611]; protein heterotetramerization [GO:0051290]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic spindle organization [GO:0060236]; regulation of proteasomal protein catabolic process [GO:0061136]; response to fluid shear stress [GO:0034405]; skin development [GO:0043588]; spinal cord development [GO:0021510]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10339594, ECO:0000269|PubMed:20980620, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:27259053, ECO:0000269|PubMed:30093605}; Multi-pass membrane protein {ECO:0000269|PubMed:20980620, ECO:0000269|PubMed:30093605}. Cell projection, cilium {ECO:0000250|UniProtKB:O08852}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O08852}. Golgi apparatus {ECO:0000250|UniProtKB:O08852}. Note=PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autoproteolytic cleavage at the GPS domain. PKD1:PKD2 interaction is required to reach the Golgi apparatus from endoplasmic reticulum and then traffic to the cilia (By similarity). Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (By similarity). Cell surface localization requires GANAB (PubMed:27259053). {ECO:0000250|UniProtKB:O08852, ECO:0000269|PubMed:27259053}.
P98164	reviewed	LRP2_HUMAN	Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)	LRP2	Homo sapiens (Human)	4655	FUNCTION: Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By similarity). {ECO:0000250|UniProtKB:A2ARV4, ECO:0000250|UniProtKB:C0HL13, ECO:0000250|UniProtKB:P98158, ECO:0000269|PubMed:15126248, ECO:0000269|PubMed:23825075}.		amyloid-beta clearance [GO:0097242]; aorta development [GO:0035904]; cellular response to growth factor stimulus [GO:0071363]; cobalamin transport [GO:0015889]; coronary artery morphogenesis [GO:0060982]; diol metabolic process [GO:0034311]; endocytosis [GO:0006897]; folate import across plasma membrane [GO:1904447]; forebrain development [GO:0030900]; kidney development [GO:0001822]; lipid metabolic process [GO:0006629]; male gonad development [GO:0008584]; metal ion transport [GO:0030001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; neural tube closure [GO:0001843]; neuron projection arborization [GO:0140058]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of neurogenesis [GO:0050769]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein transport [GO:0015031]; pulmonary artery morphogenesis [GO:0061156]; receptor-mediated endocytosis [GO:0006898]; response to leptin [GO:0044321]; retinoid metabolic process [GO:0001523]; secondary heart field specification [GO:0003139]; sensory perception of sound [GO:0007605]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]; vagina development [GO:0060068]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum development [GO:0003281]; vitamin D metabolic process [GO:0042359]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; brush border membrane [GO:0031526]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; hormone binding [GO:0042562]; insulin-like growth factor I binding [GO:0031994]; low-density lipoprotein particle receptor activity [GO:0005041]; protein transporter activity [GO:0140318]; protein-folding chaperone binding [GO:0051087]; SH3 domain binding [GO:0017124]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; brush border membrane [GO:0031526]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; hormone binding [GO:0042562]; insulin-like growth factor I binding [GO:0031994]; low-density lipoprotein particle receptor activity [GO:0005041]; protein transporter activity [GO:0140318]; protein-folding chaperone binding [GO:0051087]; SH3 domain binding [GO:0017124]; amyloid-beta clearance [GO:0097242]; aorta development [GO:0035904]; cellular response to growth factor stimulus [GO:0071363]; cobalamin transport [GO:0015889]; coronary artery morphogenesis [GO:0060982]; diol metabolic process [GO:0034311]; endocytosis [GO:0006897]; folate import across plasma membrane [GO:1904447]; forebrain development [GO:0030900]; kidney development [GO:0001822]; lipid metabolic process [GO:0006629]; male gonad development [GO:0008584]; metal ion transport [GO:0030001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; neural tube closure [GO:0001843]; neuron projection arborization [GO:0140058]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of neurogenesis [GO:0050769]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein transport [GO:0015031]; pulmonary artery morphogenesis [GO:0061156]; receptor-mediated endocytosis [GO:0006898]; response to leptin [GO:0044321]; retinoid metabolic process [GO:0001523]; secondary heart field specification [GO:0003139]; sensory perception of sound [GO:0007605]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]; vagina development [GO:0060068]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum development [GO:0003281]; vitamin D metabolic process [GO:0042359]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:23825075, ECO:0000269|PubMed:27798286}; Single-pass type I membrane protein {ECO:0000255}. Endosome lumen {ECO:0000250|UniProtKB:P98158}. Membrane, coated pit {ECO:0000250|UniProtKB:A2ARV4}. Cell projection, dendrite {ECO:0000250|UniProtKB:A2ARV4}. Cell projection, axon {ECO:0000250|UniProtKB:A2ARV4}. Note=Localizes to brush border membranes in the kidney. In the endolymphatic sac of the inner ear, located in the lumen of endosomes as a soluble form. {ECO:0000250|UniProtKB:P98158}.
P98168	reviewed	ZXDA_HUMAN	Zinc finger X-linked protein ZXDA	ZXDA	Homo sapiens (Human)	799	FUNCTION: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. {ECO:0000269|PubMed:17493635}.		positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	C2H2 zinc finger domain binding [GO:0070742]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	nucleus [GO:0005634]; C2H2 zinc finger domain binding [GO:0070742]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P98170	reviewed	XIAP_HUMAN	E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)	XIAP API3 BIRC4 IAP3	Homo sapiens (Human)	497	FUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis (PubMed:11447297, PubMed:12121969, PubMed:9230442, PubMed:11257230, PubMed:11257231, PubMed:12620238, PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:17560374). Acts as a direct caspase inhibitor (PubMed:11257230, PubMed:11257231, PubMed:12620238). Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry (PubMed:11257230, PubMed:11257231, PubMed:16352606, PubMed:16916640). Inactivates CASP9 by keeping it in a monomeric, inactive state (PubMed:12620238). Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin (PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:22607974, PubMed:30026309, PubMed:29452636, PubMed:17560374). Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (PubMed:19667203, PubMed:22607974, PubMed:30026309, PubMed:29452636). 'Lys-63'-linked polyubiquitination of RIPK2 also promotes recruitment of the LUBAC complex to RIPK2 (PubMed:22607974, PubMed:29452636). Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation (PubMed:17560374). Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation (PubMed:20154138). Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation (PubMed:17967870, PubMed:22103349). Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation (PubMed:14685266). Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation (PubMed:21145488). Ubiquitinates and therefore mediates the proteasomal degradation of BCL2 in response to apoptosis (PubMed:29020630). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner (PubMed:22095281). Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8 (PubMed:22095281). Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES (PubMed:22304967). Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program (PubMed:22304967). {ECO:0000269|PubMed:11257230, ECO:0000269|PubMed:11257231, ECO:0000269|PubMed:11447297, ECO:0000269|PubMed:12121969, ECO:0000269|PubMed:12620238, ECO:0000269|PubMed:14685266, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:17560374, ECO:0000269|PubMed:17967870, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:19667203, ECO:0000269|PubMed:20154138, ECO:0000269|PubMed:21145488, ECO:0000269|PubMed:22103349, ECO:0000269|PubMed:22304967, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:29020630, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:9230442, ECO:0000303|PubMed:22095281}.		copper ion homeostasis [GO:0055070]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; neuron apoptotic process [GO:0051402]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of type I interferon production [GO:0032481]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptosis involved in tissue homeostasis [GO:0060785]; regulation of apoptotic process [GO:0042981]; regulation of BMP signaling pathway [GO:0030510]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; endopeptidase regulator activity [GO:0061135]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein serine/threonine kinase binding [GO:0120283]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; endopeptidase regulator activity [GO:0061135]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein serine/threonine kinase binding [GO:0120283]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; copper ion homeostasis [GO:0055070]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; neuron apoptotic process [GO:0051402]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of type I interferon production [GO:0032481]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptosis involved in tissue homeostasis [GO:0060785]; regulation of apoptotic process [GO:0042981]; regulation of BMP signaling pathway [GO:0030510]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22304967}. Nucleus {ECO:0000269|PubMed:15665297, ECO:0000269|PubMed:22304967}. Note=TLE3 promotes its nuclear localization. {ECO:0000269|PubMed:22304967}.
P98171	reviewed	RHG04_HUMAN	Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115)	ARHGAP4 KIAA0131 RGC1 RHOGAP4	Homo sapiens (Human)	946	FUNCTION: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.		cytoskeleton organization [GO:0007010]; negative regulation of axon extension [GO:0030517]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast migration [GO:0010764]; nervous system development [GO:0007399]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]	GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; cytoskeleton organization [GO:0007010]; negative regulation of axon extension [GO:0030517]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast migration [GO:0010764]; nervous system development [GO:0007399]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm. Note=Just below the plasma membrane.
P98172	reviewed	EFNB1_HUMAN	Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)]	EFNB1 EFL3 EPLG2 LERK2	Homo sapiens (Human)	346	FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250|UniProtKB:P52795, ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}.		axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; embryonic pattern specification [GO:0009880]; ephrin receptor signaling pathway [GO:0048013]; neural crest cell migration [GO:0001755]; positive regulation of T cell proliferation [GO:0042102]; regulation of autophagosome assembly [GO:2000785]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]	ephrin receptor binding [GO:0046875]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; ephrin receptor binding [GO:0046875]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; embryonic pattern specification [GO:0009880]; ephrin receptor signaling pathway [GO:0048013]; neural crest cell migration [GO:0001755]; positive regulation of T cell proliferation [GO:0042102]; regulation of autophagosome assembly [GO:2000785]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10197531, ECO:0000269|PubMed:7973638}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:10197531}. Note=May recruit GRIP1 and GRIP2 to membrane raft domains. {ECO:0000269|PubMed:10197531}.; SUBCELLULAR LOCATION: [Ephrin-B1 C-terminal fragment]: Cell membrane {ECO:0000269|PubMed:16930449}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Ephrin-B1 intracellular domain]: Nucleus {ECO:0000269|PubMed:16930449}. Note=Colocalizes with ZHX2 in the nucleus. {ECO:0000250|UniProtKB:P52795}.
P98174	reviewed	FGD1_HUMAN	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3)	FGD1 FGDY ZFYVE3	Homo sapiens (Human)	961	FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}.		actin cytoskeleton organization [GO:0030036]; animal organ morphogenesis [GO:0009887]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726]	guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; animal organ morphogenesis [GO:0009887]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with membrane ruffles and lamellipodia. {ECO:0000250}.
P98175	reviewed	RBM10_HUMAN	RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1)	RBM10 DXS8237E GPATC9 GPATCH9 KIAA0122	Homo sapiens (Human)	930	FUNCTION: May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:28431233}.	MISCELLANEOUS: RBM10 transcripts also code for an alternative open reading frame (alt-ORF) coding for the MINAS-60 (AC P0DW28) protein (Probable). MINAS-60 and RBM10 ORFs are overlapping and are formed by shifting the reading frame (Probable). {ECO:0000305}.	3'-UTR-mediated mRNA stabilization [GO:0070935]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; vascular associated smooth muscle cell apoptotic process [GO:1905288]; vascular associated smooth muscle cell proliferation [GO:1990874]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; vascular associated smooth muscle cell apoptotic process [GO:1905288]; vascular associated smooth muscle cell proliferation [GO:1990874]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18315527}. Note=In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).
P98177	reviewed	FOXO4_HUMAN	Forkhead box protein O4 (Fork head domain transcription factor AFX1)	FOXO4 AFX AFX1 MLLT7	Homo sapiens (Human)	505	FUNCTION: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}.		insulin receptor signaling pathway [GO:0008286]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; muscle organ development [GO:0007517]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to nutrient levels [GO:0031667]; response to oxidative stress [GO:0006979]; response to water-immersion restraint stress [GO:1990785]; stem cell differentiation [GO:0048863]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; insulin receptor signaling pathway [GO:0008286]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; muscle organ development [GO:0007517]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to nutrient levels [GO:0031667]; response to oxidative stress [GO:0006979]; response to water-immersion restraint stress [GO:1990785]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
P98179	reviewed	RBM3_HUMAN	RNA-binding protein 3 (RNA-binding motif protein 3) (RNPL)	RBM3 RNPL	Homo sapiens (Human)	157	FUNCTION: Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity). {ECO:0000250}.		positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of translation [GO:0045727]; regulation of translation [GO:0006417]; RNA processing [GO:0006396]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of translation [GO:0045727]; regulation of translation [GO:0006417]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Localizes in mRNA granules in dentrites. {ECO:0000250}.
P98187	reviewed	CP4F8_HUMAN	Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8)	CYP4F8	Homo sapiens (Human)	520	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-1 and omega-2 positions (PubMed:10791960, PubMed:16112640, PubMed:15789615). Hydroxylates (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) predominantly at omega-2 position to form (18R)-hydroxyeicosatetraenoic acid (18R-HETE) (PubMed:10791960). Exhibits omega-1 hydroxylase activity toward prostaglandin (PG) H1, PGH2 and PGI2 (PubMed:10791960, PubMed:15789615). Catalyzes the epoxidation of double bonds of PUFAs, including docosahexaenoic and docosapentaenoic acids (PubMed:16112640). Shows little activity against PGD2, PGE1, PGE2, PGF2alpha, and leukotriene B4. {ECO:0000269|PubMed:10791960, ECO:0000269|PubMed:15789615, ECO:0000269|PubMed:16112640}.		icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693]	endoplasmic reticulum membrane [GO:0005789]	alkane 1-monooxygenase activity [GO:0018685]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]	endoplasmic reticulum membrane [GO:0005789]; alkane 1-monooxygenase activity [GO:0018685]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9HBI6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9HBI6}. Microsome membrane {ECO:0000250|UniProtKB:Q9HBI6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9HBI6}.
P98194	reviewed	AT2C1_HUMAN	Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1)	ATP2C1 KIAA1347 PMR1L HUSSY-28	Homo sapiens (Human)	919	FUNCTION: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:16192278, PubMed:30923126, PubMed:21187401, PubMed:12707275, PubMed:20439740). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:16192278, PubMed:16332677, PubMed:30923126). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology (PubMed:20439740, PubMed:14632183). Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (PubMed:14632183, PubMed:10615129, PubMed:20439740). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401). {ECO:0000250|UniProtKB:Q80XR2, ECO:0000269|PubMed:10615129, ECO:0000269|PubMed:12707275, ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:16192278, ECO:0000269|PubMed:16332677, ECO:0000269|PubMed:20439740, ECO:0000269|PubMed:21187401, ECO:0000269|PubMed:30923126}.		actin cytoskeleton organization [GO:0030036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; epidermis development [GO:0008544]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; intracellular calcium ion homeostasis [GO:0006874]; intracellular manganese ion homeostasis [GO:0030026]; manganese ion transport [GO:0006828]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; trans-Golgi network membrane organization [GO:0098629]	cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type manganese transporter activity [GO:0140613]	cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type manganese transporter activity [GO:0140613]; actin cytoskeleton organization [GO:0030036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; epidermis development [GO:0008544]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; intracellular calcium ion homeostasis [GO:0006874]; intracellular manganese ion homeostasis [GO:0030026]; manganese ion transport [GO:0006828]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; trans-Golgi network membrane organization [GO:0098629]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12707275, ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:21187401}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:21187401}; Multi-pass membrane protein {ECO:0000255}. Note=During neuron differentiation, shifts from juxtanuclear Golgi position to multiple Golgi structures distributed over the neural soma with a predominance in the apical dendritic trunk. {ECO:0000250|UniProtKB:Q80XR2}.
P98196	reviewed	AT11A_HUMAN	Phospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A)	ATP11A ATPIH ATPIS KIAA1021	Homo sapiens (Human)	1134	FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:25947375, PubMed:26567335, PubMed:29799007, PubMed:30018401). Does not show flippase activity toward phosphatidylcholine (PC) (PubMed:34403372). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. {ECO:0000269|PubMed:15860663, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:26567335, ECO:0000269|PubMed:29799007, ECO:0000269|PubMed:30018401, ECO:0000269|PubMed:34403372, ECO:0000305}.	MISCELLANEOUS: Overexpression of ATP11A confers resistance to lonafarnib.	in utero embryonic development [GO:0001701]; phospholipid translocation [GO:0045332]; positive regulation of myotube differentiation [GO:0010831]; regulation of membrane lipid distribution [GO:0097035]	early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556]	early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556]; in utero embryonic development [GO:0001701]; phospholipid translocation [GO:0045332]; positive regulation of myotube differentiation [GO:0010831]; regulation of membrane lipid distribution [GO:0097035]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:34403372}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:21914794}. Recycling endosome {ECO:0000269|PubMed:21914794}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:25947375}; Multi-pass membrane protein {ECO:0000255}. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. {ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:25947375}.
P98198	reviewed	AT8B2_HUMAN	Phospholipid-transporting ATPase ID (EC 7.6.2.1) (ATPase class I type 8B member 2) (P4-ATPase flippase complex alpha subunit ATP8B2)	ATP8B2 ATPID KIAA1137	Homo sapiens (Human)	1209	FUNCTION: Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. May contribute to the maintenance of membrane lipid asymmetry. {ECO:0000269|PubMed:25315773}.		Golgi organization [GO:0007030]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine floppase activity [GO:0090554]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine floppase activity [GO:0090554]; Golgi organization [GO:0007030]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:25315773}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20961850}; Multi-pass membrane protein {ECO:0000255}. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A or TMEM30B. {ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:25315773}.
P99999	reviewed	CYC_HUMAN	Cytochrome c	CYCS CYC	Homo sapiens (Human)	105	FUNCTION: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.; FUNCTION: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.		activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; cellular respiration [GO:0045333]; intrinsic apoptotic signaling pathway [GO:0097193]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	apoptosome [GO:0043293]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; respirasome [GO:0070469]	electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]	apoptosome [GO:0043293]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; respirasome [GO:0070469]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; cellular respiration [GO:0045333]; intrinsic apoptotic signaling pathway [GO:0097193]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Q00005	reviewed	2ABB_HUMAN	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta)	PPP2R2B	Homo sapiens (Human)	443	FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: Conserved additional ATG codons are found 5' of the putative initiator codon in transcripts supporting isoform 1. They may initiate the translation of upstream short open reading frames altering the expression of that isoform as described in PubMed:1849734.; MISCELLANEOUS: [Isoform 2]: Contains a cryptic mitochondrial transit peptide at positions 1-26. {ECO:0000250}.	apoptotic process [GO:0006915]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase regulator activity [GO:0019888]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein phosphatase type 2A complex [GO:0000159]; protein phosphatase regulator activity [GO:0019888]; apoptotic process [GO:0006915]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Note=Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity). {ECO:0000250}.
Q00013	reviewed	EM55_HUMAN	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1)	MPP1 DXS552E EMP55	Homo sapiens (Human)	466	FUNCTION: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). {ECO:0000250}.		regulation of neutrophil chemotaxis [GO:0090022]; signal transduction [GO:0007165]	cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cortical cytoskeleton [GO:0030863]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]	guanylate kinase activity [GO:0004385]; signaling receptor binding [GO:0005102]	cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cortical cytoskeleton [GO:0030863]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; guanylate kinase activity [GO:0004385]; signaling receptor binding [GO:0005102]; regulation of neutrophil chemotaxis [GO:0090022]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19144871}; Lipid-anchor {ECO:0000305|PubMed:1713685}. Cell projection, stereocilium {ECO:0000250|UniProtKB:P70290}. Note=Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity). Colocalizes with PALS1 in the retina, at the outer limiting membrane (OLM) (By similarity). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC) (By similarity). Colocalizes with NF2 in non-myelin-forming Schwann cells (PubMed:19144871). {ECO:0000250|UniProtKB:P70290, ECO:0000269|PubMed:19144871}.
Q00056	reviewed	HXA4_HUMAN	Homeobox protein Hox-A4 (Homeobox protein Hox-1.4) (Homeobox protein Hox-1D)	HOXA4 HOX1D	Homo sapiens (Human)	320	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.		anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus.
Q00059	reviewed	TFAM_HUMAN	Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2)	TFAM TCF6 TCF6L2	Homo sapiens (Human)	246	FUNCTION: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172). Is able to unwind DNA (PubMed:22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed:22841477, PubMed:19304746). May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171). {ECO:0000269|PubMed:1737790, ECO:0000269|PubMed:19304746, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:22037171, ECO:0000269|PubMed:22037172, ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:29445193, ECO:0000269|PubMed:32183942}.		mitochondrial respiratory chain complex assembly [GO:0033108]; mitochondrial transcription [GO:0006390]; positive regulation of DNA-templated transcription [GO:0045893]; transcription initiation at mitochondrial promoter [GO:0006391]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; heat shock protein binding [GO:0031072]; mitochondrial promoter sequence-specific DNA binding [GO:0001018]; mitochondrial transcription factor activity [GO:0034246]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; heat shock protein binding [GO:0031072]; mitochondrial promoter sequence-specific DNA binding [GO:0001018]; mitochondrial transcription factor activity [GO:0034246]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; mitochondrial respiratory chain complex assembly [GO:0033108]; mitochondrial transcription [GO:0006390]; positive regulation of DNA-templated transcription [GO:0045893]; transcription initiation at mitochondrial promoter [GO:0006391]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:1737790, ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:29445193}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.
Q00169	reviewed	PIPNA_HUMAN	Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha)	PITPNA PITPN	Homo sapiens (Human)	270	FUNCTION: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:10531358, PubMed:22822086, PubMed:15522822, PubMed:18636990, PubMed:14962392). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (PubMed:15522822, PubMed:22822086). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (PubMed:22822086). {ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:14962392, ECO:0000269|PubMed:15522822, ECO:0000269|PubMed:18636990, ECO:0000269|PubMed:22822086}.		lipid metabolic process [GO:0006629]; phospholipid transport [GO:0015914]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	lipid binding [GO:0008289]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylglycerol binding [GO:1901611]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; lipid binding [GO:0008289]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylglycerol binding [GO:1901611]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; lipid metabolic process [GO:0006629]; phospholipid transport [GO:0015914]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P53810}. Nucleus {ECO:0000250|UniProtKB:P53810}.
Q00266	reviewed	METK1_HUMAN	S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III)	MAT1A AMS1 MATA1	Homo sapiens (Human)	395	FUNCTION: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10677294}.		methionine catabolic process [GO:0009087]; one-carbon metabolic process [GO:0006730]; protein homotetramerization [GO:0051289]; S-adenosylmethionine biosynthetic process [GO:0006556]	cytosol [GO:0005829]; methionine adenosyltransferase complex [GO:0048269]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methionine adenosyltransferase activity [GO:0004478]	cytosol [GO:0005829]; methionine adenosyltransferase complex [GO:0048269]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methionine adenosyltransferase activity [GO:0004478]; methionine catabolic process [GO:0009087]; one-carbon metabolic process [GO:0006730]; protein homotetramerization [GO:0051289]; S-adenosylmethionine biosynthetic process [GO:0006556]	
Q00325	reviewed	S25A3_HUMAN	Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP)	SLC25A3 PHC OK/SW-cl.48	Homo sapiens (Human)	362	FUNCTION: Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity) (PubMed:17273968, PubMed:29237729). Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity) (PubMed:17273968). Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (PubMed:29237729). May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity). {ECO:0000250|UniProtKB:P12234, ECO:0000250|UniProtKB:P16036, ECO:0000269|PubMed:17273968, ECO:0000269|PubMed:29237729}.		mitochondrial phosphate ion transmembrane transport [GO:1990547]; phosphate ion transmembrane transport [GO:0035435]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	inorganic phosphate transmembrane transporter activity [GO:0005315]; phosphate:proton symporter activity [GO:0015317]; protein-containing complex binding [GO:0044877]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; inorganic phosphate transmembrane transporter activity [GO:0005315]; phosphate:proton symporter activity [GO:0015317]; protein-containing complex binding [GO:0044877]; mitochondrial phosphate ion transmembrane transport [GO:1990547]; phosphate ion transmembrane transport [GO:0035435]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P12234}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P12234}.
Q00341	reviewed	VIGLN_HUMAN	Vigilin (High density lipoprotein-binding protein) (HDL-binding protein)	HDLBP HBP VGL	Homo sapiens (Human)	1268	FUNCTION: Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.		cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869]	cytoplasm [GO:0005737]; high-density lipoprotein particle [GO:0034364]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polysome [GO:0005844]	cadherin binding [GO:0045296]; lipid binding [GO:0008289]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; high-density lipoprotein particle [GO:0034364]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polysome [GO:0005844]; cadherin binding [GO:0045296]; lipid binding [GO:0008289]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8605996}. Nucleus {ECO:0000269|PubMed:8605996}.
Q00403	reviewed	TF2B_HUMAN	Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II)	GTF2B TF2B TFIIB	Homo sapiens (Human)	316	FUNCTION: General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:1876184, PubMed:1946368, PubMed:1517211, PubMed:3818643, PubMed:3029109, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:7601352, PubMed:9420329, PubMed:12931194, PubMed:27193682). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8504927, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:9420329, PubMed:16230532, PubMed:7675079, PubMed:10619841). Modulates transcription start site selection (PubMed:10318856). Exhibits also autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194). {ECO:0000269|PubMed:10318856, ECO:0000269|PubMed:10619841, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:1517211, ECO:0000269|PubMed:16230532, ECO:0000269|PubMed:1876184, ECO:0000269|PubMed:1946368, ECO:0000269|PubMed:24441171, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:3029109, ECO:0000269|PubMed:3818643, ECO:0000269|PubMed:7601352, ECO:0000269|PubMed:7675079, ECO:0000269|PubMed:8413225, ECO:0000269|PubMed:8504927, ECO:0000269|PubMed:8515820, ECO:0000269|PubMed:8516311, ECO:0000269|PubMed:8516312, ECO:0000269|PubMed:9420329}.		meiotic sister chromatid cohesion [GO:0051177]; positive regulation of core promoter binding [GO:1904798]; protein acetylation [GO:0006473]; RNA polymerase II core complex assembly [GO:1990114]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spindle assembly [GO:0051225]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcriptional start site selection at RNA polymerase II promoter [GO:0001174]; viral transcription [GO:0019083]	cell division site [GO:0032153]; chromosome [GO:0005694]; germinal vesicle [GO:0042585]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor TFIID complex [GO:0005669]; transcription preinitiation complex [GO:0097550]	acetyltransferase activity [GO:0016407]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; nuclear thyroid hormone receptor binding [GO:0046966]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]; zinc ion binding [GO:0008270]	cell division site [GO:0032153]; chromosome [GO:0005694]; germinal vesicle [GO:0042585]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor TFIID complex [GO:0005669]; transcription preinitiation complex [GO:0097550]; acetyltransferase activity [GO:0016407]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; nuclear thyroid hormone receptor binding [GO:0046966]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]; zinc ion binding [GO:0008270]; meiotic sister chromatid cohesion [GO:0051177]; positive regulation of core promoter binding [GO:1904798]; protein acetylation [GO:0006473]; RNA polymerase II core complex assembly [GO:1990114]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spindle assembly [GO:0051225]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcriptional start site selection at RNA polymerase II promoter [GO:0001174]; viral transcription [GO:0019083]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12931194}. Chromosome {ECO:0000269|PubMed:24441171}. Note=Non-acetylated form colocalizes with DNA in the G0/1, S and G2 phases of the cell cycle, but not during mitosis (PubMed:24441171). Acetylated form colocalizes at transcriptionally silent mitotic chromatids during mitosis at metaphase, anaphase, and telophase phases of the cell cycle (PubMed:24441171). {ECO:0000269|PubMed:24441171}.
Q00444	reviewed	HXC5_HUMAN	Homeobox protein Hox-C5 (Homeobox protein CP11) (Homeobox protein Hox-3D)	HOXC5 HOX3D	Homo sapiens (Human)	222	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system development [GO:0048706]; regulation of transcription by RNA polymerase II [GO:0006357]	cell junction [GO:0030054]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cell junction [GO:0030054]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system development [GO:0048706]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q00526	reviewed	CDK3_HUMAN	Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)	CDK3 CDKN3	Homo sapiens (Human)	305	FUNCTION: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. {ECO:0000269|PubMed:15084261, ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:8846921}.		cell division [GO:0051301]; cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; G0 to G1 transition [GO:0045023]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of Notch signaling pathway [GO:0045746]; phosphorylation [GO:0016310]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; response to organic substance [GO:0010033]; signal transduction [GO:0007165]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; G0 to G1 transition [GO:0045023]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of Notch signaling pathway [GO:0045746]; phosphorylation [GO:0016310]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; response to organic substance [GO:0010033]; signal transduction [GO:0007165]	
Q00532	reviewed	CDKL1_HUMAN	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Protein kinase p42 KKIALRE) (Serine/threonine-protein kinase KKIALRE)	CDKL1	Homo sapiens (Human)	358			protein phosphorylation [GO:0006468]; regulation of cilium assembly [GO:1902017]	ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein phosphorylation [GO:0006468]; regulation of cilium assembly [GO:1902017]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9000130}. Nucleus {ECO:0000269|PubMed:9000130}.
Q00534	reviewed	CDK6_HUMAN	Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)	CDK6 CDKN6	Homo sapiens (Human)	326	FUNCTION: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}.	MISCELLANEOUS: Over-expressed in some leukemias and malignancies (including sarcoma, glioma, breast tumors, lymphoma and melanoma) as a consequence of nearby translocations.; MISCELLANEOUS: Enhances beta-cells engraftment in pancreatic islets of Langerhans of diabetic patients.	astrocyte development [GO:0014002]; cell dedifferentiation [GO:0043697]; cell division [GO:0051301]; dentate gyrus development [GO:0021542]; G1/S transition of mitotic cell cycle [GO:0000082]; generation of neurons [GO:0048699]; gliogenesis [GO:0042063]; hematopoietic stem cell differentiation [GO:0060218]; lateral ventricle development [GO:0021670]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular senescence [GO:2000773]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of cell motility [GO:2000145]; regulation of erythrocyte differentiation [GO:0045646]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; regulation of hematopoietic stem cell differentiation [GO:1902036]; response to organic substance [GO:0010033]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]; type B pancreatic cell development [GO:0003323]	centrosome [GO:0005813]; cyclin D2-CDK6 complex [GO:0097132]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726]	ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; FBXO family protein binding [GO:0098770]; protein serine kinase activity [GO:0106310]	centrosome [GO:0005813]; cyclin D2-CDK6 complex [GO:0097132]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726]; ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; FBXO family protein binding [GO:0098770]; protein serine kinase activity [GO:0106310]; astrocyte development [GO:0014002]; cell dedifferentiation [GO:0043697]; cell division [GO:0051301]; dentate gyrus development [GO:0021542]; G1/S transition of mitotic cell cycle [GO:0000082]; generation of neurons [GO:0048699]; gliogenesis [GO:0042063]; hematopoietic stem cell differentiation [GO:0060218]; lateral ventricle development [GO:0021670]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular senescence [GO:2000773]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of cell motility [GO:2000145]; regulation of erythrocyte differentiation [GO:0045646]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; regulation of hematopoietic stem cell differentiation [GO:1902036]; response to organic substance [GO:0010033]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]; type B pancreatic cell development [GO:0003323]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23918663}. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). {ECO:0000250|UniProtKB:Q64261, ECO:0000269|PubMed:23918663}.
Q00535	reviewed	CDK5_HUMAN	Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)	CDK5 CDKN5 PSSALRE	Homo sapiens (Human)	292	FUNCTION: Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Negatively regulates the CACNA1B/CAV2.2 -mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in postmitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000250|UniProtKB:Q03114, ECO:0000269|PubMed:12393264, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15992363, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17121855, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17611284, ECO:0000269|PubMed:17671990, ECO:0000269|PubMed:18042622, ECO:0000269|PubMed:19081376, ECO:0000269|PubMed:19693690, ECO:0000269|PubMed:20061803, ECO:0000269|PubMed:20213743, ECO:0000269|PubMed:20826806, ECO:0000269|PubMed:21209322, ECO:0000269|PubMed:21220307, ECO:0000269|PubMed:21442427, ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:21499257, ECO:0000269|PubMed:24235147, ECO:0000269|PubMed:9822744}.	MISCELLANEOUS: Dysregulation of CDK5 is associated with neurodegenerative disorders such as Alzheimer, Parkinson, and Niemann-Pick type C diseases, ischemia, and amyotrophic lateral sclerosis.	axon extension [GO:0048675]; axonogenesis [GO:0007409]; behavioral response to cocaine [GO:0048148]; calcium ion import [GO:0070509]; cell division [GO:0051301]; cell-matrix adhesion [GO:0007160]; cellular response to amyloid-beta [GO:1904646]; central nervous system neuron development [GO:0021954]; cerebellar cortex formation [GO:0021697]; chemical synaptic transmission [GO:0007268]; corpus callosum development [GO:0022038]; dendrite morphogenesis [GO:0048813]; excitatory postsynaptic potential [GO:0060079]; hippocampus development [GO:0021766]; intracellular protein transport [GO:0006886]; layer formation in cerebral cortex [GO:0021819]; microtubule cytoskeleton organization [GO:0000226]; motor neuron axon guidance [GO:0008045]; negative regulation of axon extension [GO:0030517]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of proteolysis [GO:0045861]; negative regulation of synaptic plasticity [GO:0031914]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; oligodendrocyte differentiation [GO:0048709]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein targeting to membrane [GO:0090314]; protein localization to synapse [GO:0035418]; protein phosphorylation [GO:0006468]; receptor catabolic process [GO:0032801]; receptor clustering [GO:0043113]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of macroautophagy [GO:0016241]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle recycling [GO:1903421]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; rhythmic process [GO:0048511]; Schwann cell development [GO:0014044]; sensory perception of pain [GO:0019233]; skeletal muscle tissue development [GO:0007519]; synapse assembly [GO:0007416]; synaptic transmission, dopaminergic [GO:0001963]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle transport [GO:0048489]; visual learning [GO:0008542]	axon [GO:0030424]; cell junction [GO:0030054]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; protein kinase 5 complex [GO:0016533]	acetylcholine receptor activator activity [GO:0030549]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; ErbB-2 class receptor binding [GO:0005176]; ErbB-3 class receptor binding [GO:0043125]; Hsp90 protein binding [GO:0051879]; kinase activity [GO:0016301]; p53 binding [GO:0002039]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	axon [GO:0030424]; cell junction [GO:0030054]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; protein kinase 5 complex [GO:0016533]; acetylcholine receptor activator activity [GO:0030549]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; ErbB-2 class receptor binding [GO:0005176]; ErbB-3 class receptor binding [GO:0043125]; Hsp90 protein binding [GO:0051879]; kinase activity [GO:0016301]; p53 binding [GO:0002039]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; behavioral response to cocaine [GO:0048148]; calcium ion import [GO:0070509]; cell division [GO:0051301]; cell-matrix adhesion [GO:0007160]; cellular response to amyloid-beta [GO:1904646]; central nervous system neuron development [GO:0021954]; cerebellar cortex formation [GO:0021697]; chemical synaptic transmission [GO:0007268]; corpus callosum development [GO:0022038]; dendrite morphogenesis [GO:0048813]; excitatory postsynaptic potential [GO:0060079]; hippocampus development [GO:0021766]; intracellular protein transport [GO:0006886]; layer formation in cerebral cortex [GO:0021819]; microtubule cytoskeleton organization [GO:0000226]; motor neuron axon guidance [GO:0008045]; negative regulation of axon extension [GO:0030517]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of proteolysis [GO:0045861]; negative regulation of synaptic plasticity [GO:0031914]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; oligodendrocyte differentiation [GO:0048709]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein targeting to membrane [GO:0090314]; protein localization to synapse [GO:0035418]; protein phosphorylation [GO:0006468]; receptor catabolic process [GO:0032801]; receptor clustering [GO:0043113]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of macroautophagy [GO:0016241]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle recycling [GO:1903421]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; rhythmic process [GO:0048511]; Schwann cell development [GO:0014044]; sensory perception of pain [GO:0019233]; skeletal muscle tissue development [GO:0007519]; synapse assembly [GO:0007416]; synaptic transmission, dopaminergic [GO:0001963]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle transport [GO:0048489]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:12691662}. Nucleus {ECO:0000269|PubMed:12691662}. Cell membrane {ECO:0000269|PubMed:17009320}; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P49615}. Cell projection, growth cone {ECO:0000250|UniProtKB:P49615}. Postsynaptic density {ECO:0000250|UniProtKB:Q03114}. Synapse {ECO:0000250|UniProtKB:Q03114}. Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
Q00536	reviewed	CDK16_HUMAN	Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)	CDK16 PCTAIRE1 PCTK1	Homo sapiens (Human)	496	FUNCTION: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}.		exocytosis [GO:0006887]; growth hormone secretion [GO:0030252]; neuron projection development [GO:0031175]; positive regulation of autophagy [GO:0010508]; protein phosphorylation [GO:0006468]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; spermatogenesis [GO:0007283]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; exocytosis [GO:0006887]; growth hormone secretion [GO:0030252]; neuron projection development [GO:0031175]; positive regulation of autophagy [GO:0010508]; protein phosphorylation [GO:0006468]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Synapse, synaptosome {ECO:0000250}. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.
Q00537	reviewed	CDK17_HUMAN	Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2)	CDK17 PCTAIRE2 PCTK2	Homo sapiens (Human)	523	FUNCTION: May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}.		protein phosphorylation [GO:0006468]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein phosphorylation [GO:0006468]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	
Q00577	reviewed	PURA_HUMAN	Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)	PURA PUR1	Homo sapiens (Human)	322	FUNCTION: This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.		dendritic transport of messenger ribonucleoprotein complex [GO:0098963]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; epithelial cell proliferation [GO:0050673]; lymphocyte proliferation [GO:0046651]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]; regulation of transcription by RNA polymerase II [GO:0006357]	chromosome, telomeric region [GO:0000781]; dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynapse [GO:0098794]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; double-stranded telomeric DNA binding [GO:0003691]; mRNA regulatory element binding translation repressor activity [GO:0000900]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; single-stranded DNA binding [GO:0003697]; SMAD binding [GO:0046332]; transcription regulator inhibitor activity [GO:0140416]	chromosome, telomeric region [GO:0000781]; dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynapse [GO:0098794]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; double-stranded telomeric DNA binding [GO:0003691]; mRNA regulatory element binding translation repressor activity [GO:0000900]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; single-stranded DNA binding [GO:0003697]; SMAD binding [GO:0046332]; transcription regulator inhibitor activity [GO:0140416]; dendritic transport of messenger ribonucleoprotein complex [GO:0098963]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; epithelial cell proliferation [GO:0050673]; lymphocyte proliferation [GO:0046651]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q00587	reviewed	BORG5_HUMAN	Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55)	CDC42EP1 BORG5 CEP1 MSE55	Homo sapiens (Human)	391	FUNCTION: Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}.		positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	cadherin binding involved in cell-cell adhesion [GO:0098641]; small GTPase binding [GO:0031267]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; cadherin binding involved in cell-cell adhesion [GO:0098641]; small GTPase binding [GO:0031267]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:10430899}; Peripheral membrane protein {ECO:0000269|PubMed:10430899}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10430899}.
Q00597	reviewed	FANCC_HUMAN	Fanconi anemia group C protein (Protein FACC)	FANCC FAC FACC	Homo sapiens (Human)	558	FUNCTION: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. {ECO:0000269|PubMed:11520787}.		brain morphogenesis [GO:0048854]; cellular response to oxidative stress [GO:0034599]; DNA repair [GO:0006281]; germ cell development [GO:0007281]; interstrand cross-link repair [GO:0036297]; myeloid cell homeostasis [GO:0002262]; neuronal stem cell population maintenance [GO:0097150]; nucleotide-excision repair [GO:0006289]; protein-containing complex assembly [GO:0065003]; removal of superoxide radicals [GO:0019430]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; brain morphogenesis [GO:0048854]; cellular response to oxidative stress [GO:0034599]; DNA repair [GO:0006281]; germ cell development [GO:0007281]; interstrand cross-link repair [GO:0036297]; myeloid cell homeostasis [GO:0002262]; neuronal stem cell population maintenance [GO:0097150]; nucleotide-excision repair [GO:0006289]; protein-containing complex assembly [GO:0065003]; removal of superoxide radicals [GO:0019430]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.
Q00604	reviewed	NDP_HUMAN	Norrin (Norrie disease protein) (X-linked exudative vitreoretinopathy 2 protein)	NDP EVR2	Homo sapiens (Human)	133	FUNCTION: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.		action potential [GO:0001508]; angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; canonical Wnt signaling pathway [GO:0060070]; cellular response to hypoxia [GO:0071456]; cone retinal bipolar cell differentiation [GO:1904390]; decidualization [GO:0046697]; dendritic spine development [GO:0060996]; endothelial cell differentiation [GO:0045446]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; exploration behavior [GO:0035640]; extracellular matrix-cell signaling [GO:0035426]; glutathione metabolic process [GO:0006749]; glycine metabolic process [GO:0006544]; inflammatory response [GO:0006954]; lens development in camera-type eye [GO:0002088]; microglia differentiation [GO:0014004]; microglial cell proliferation [GO:0061518]; mitotic cell cycle [GO:0000278]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; Norrin signaling pathway [GO:0110135]; optic nerve development [GO:0021554]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of DNA-templated transcription [GO:0045893]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; re-entry into mitotic cell cycle [GO:0000320]; response to axon injury [GO:0048678]; retina blood vessel maintenance [GO:0097601]; retina layer formation [GO:0010842]; retinal blood vessel morphogenesis [GO:0061304]; retinal ganglion cell axon guidance [GO:0031290]; retinal pigment epithelium development [GO:0003406]; retinal rod cell differentiation [GO:0060221]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tricarboxylic acid cycle [GO:0006099]; ubiquitin-dependent endocytosis [GO:0070086]; vacuole organization [GO:0007033]; visual perception [GO:0007601]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; protein homodimerization activity [GO:0042803]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; protein homodimerization activity [GO:0042803]; action potential [GO:0001508]; angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; canonical Wnt signaling pathway [GO:0060070]; cellular response to hypoxia [GO:0071456]; cone retinal bipolar cell differentiation [GO:1904390]; decidualization [GO:0046697]; dendritic spine development [GO:0060996]; endothelial cell differentiation [GO:0045446]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; exploration behavior [GO:0035640]; extracellular matrix-cell signaling [GO:0035426]; glutathione metabolic process [GO:0006749]; glycine metabolic process [GO:0006544]; inflammatory response [GO:0006954]; lens development in camera-type eye [GO:0002088]; microglia differentiation [GO:0014004]; microglial cell proliferation [GO:0061518]; mitotic cell cycle [GO:0000278]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; Norrin signaling pathway [GO:0110135]; optic nerve development [GO:0021554]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of DNA-templated transcription [GO:0045893]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; re-entry into mitotic cell cycle [GO:0000320]; response to axon injury [GO:0048678]; retina blood vessel maintenance [GO:0097601]; retina layer formation [GO:0010842]; retinal blood vessel morphogenesis [GO:0061304]; retinal ganglion cell axon guidance [GO:0031290]; retinal pigment epithelium development [GO:0003406]; retinal rod cell differentiation [GO:0060221]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tricarboxylic acid cycle [GO:0006099]; ubiquitin-dependent endocytosis [GO:0070086]; vacuole organization [GO:0007033]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9407136}.
Q00610	reviewed	CLH1_HUMAN	Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)	CLTC CLH17 CLTCL2 KIAA0034	Homo sapiens (Human)	1675	FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.		amyloid-beta clearance by transcytosis [GO:0150093]; autophagy [GO:0006914]; cell division [GO:0051301]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of protein localization to plasma membrane [GO:1903077]; osteoblast differentiation [GO:0001649]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of mitotic spindle organization [GO:0060236]; retrograde transport, endosome to Golgi [GO:0042147]; transferrin transport [GO:0033572]	clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; trans-Golgi network membrane [GO:0032588]	clathrin light chain binding [GO:0032051]; disordered domain specific binding [GO:0097718]; double-stranded RNA binding [GO:0003725]; low-density lipoprotein particle receptor binding [GO:0050750]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; ubiquitin-specific protease binding [GO:1990381]	clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; trans-Golgi network membrane [GO:0032588]; clathrin light chain binding [GO:0032051]; disordered domain specific binding [GO:0097718]; double-stranded RNA binding [GO:0003725]; low-density lipoprotein particle receptor binding [GO:0050750]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; ubiquitin-specific protease binding [GO:1990381]; amyloid-beta clearance by transcytosis [GO:0150093]; autophagy [GO:0006914]; cell division [GO:0051301]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of protein localization to plasma membrane [GO:1903077]; osteoblast differentiation [GO:0001649]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of mitotic spindle organization [GO:0060236]; retrograde transport, endosome to Golgi [GO:0042147]; transferrin transport [GO:0033572]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Membrane, coated pit {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:23918938}. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles. {ECO:0000269|PubMed:25596274}.
Q00613	reviewed	HSF1_HUMAN	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1)	HSF1 HSTF1	Homo sapiens (Human)	529	FUNCTION: Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:1871105, PubMed:11447121, PubMed:1986252, PubMed:7760831, PubMed:7623826, PubMed:8946918, PubMed:8940068, PubMed:9341107, PubMed:9121459, PubMed:9727490, PubMed:9499401, PubMed:9535852, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:25963659, PubMed:26754925, PubMed:18451878). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:9727490, PubMed:11583998, PubMed:16278218). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:1871105, PubMed:1986252, PubMed:8455624, PubMed:7935471, PubMed:7623826, PubMed:8940068, PubMed:9727490, PubMed:9499401, PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:25963659, PubMed:26754925). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}.		cellular response to angiotensin [GO:1904385]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to diamide [GO:0072738]; cellular response to estradiol stimulus [GO:0071392]; cellular response to gamma radiation [GO:0071480]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to L-glutamine [GO:1904845]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nitroglycerin [GO:1904843]; cellular response to potassium ion [GO:0035865]; cellular response to sodium arsenite [GO:1903936]; cellular response to unfolded protein [GO:0034620]; cellular response to xenobiotic stimulus [GO:0071466]; defense response [GO:0006952]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; negative regulation of gene expression [GO:0010629]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein-containing complex assembly [GO:0065003]; regulation of cellular response to heat [GO:1900034]; regulation of transcription by RNA polymerase II [GO:0006357]; response to activity [GO:0014823]; response to hypobaric hypoxia [GO:1990910]; response to nutrient [GO:0007584]; response to psychosocial stress [GO:1990911]; response to testosterone [GO:0033574]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; kinetochore [GO:0000776]; mitotic spindle pole [GO:0097431]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; protein folding chaperone complex [GO:0101031]; ribonucleoprotein complex [GO:1990904]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; general transcription initiation factor binding [GO:0140296]; heat shock protein binding [GO:0031072]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein self-association [GO:0043621]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; sequence-specific single stranded DNA binding [GO:0098847]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]; translation elongation factor binding [GO:0061770]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; kinetochore [GO:0000776]; mitotic spindle pole [GO:0097431]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; protein folding chaperone complex [GO:0101031]; ribonucleoprotein complex [GO:1990904]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; general transcription initiation factor binding [GO:0140296]; heat shock protein binding [GO:0031072]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein self-association [GO:0043621]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; sequence-specific single stranded DNA binding [GO:0098847]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]; translation elongation factor binding [GO:0061770]; cellular response to angiotensin [GO:1904385]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to diamide [GO:0072738]; cellular response to estradiol stimulus [GO:0071392]; cellular response to gamma radiation [GO:0071480]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to L-glutamine [GO:1904845]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nitroglycerin [GO:1904843]; cellular response to potassium ion [GO:0035865]; cellular response to sodium arsenite [GO:1903936]; cellular response to unfolded protein [GO:0034620]; cellular response to xenobiotic stimulus [GO:0071466]; defense response [GO:0006952]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; negative regulation of gene expression [GO:0010629]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein-containing complex assembly [GO:0065003]; regulation of cellular response to heat [GO:1900034]; regulation of transcription by RNA polymerase II [GO:0006357]; response to activity [GO:0014823]; response to hypobaric hypoxia [GO:1990910]; response to nutrient [GO:0007584]; response to psychosocial stress [GO:1990911]; response to testosterone [GO:0033574]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10413683, ECO:0000269|PubMed:10747973, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11514557, ECO:0000269|PubMed:12665592, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:19229036, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:27189267, ECO:0000269|PubMed:27354066, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:8455624}. Cytoplasm {ECO:0000269|PubMed:10413683, ECO:0000269|PubMed:10747973, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:27354066, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:8455624}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10359787}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21085490}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18794143}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18794143}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:18794143}. Note=The monomeric form is cytoplasmic in unstressed cells (PubMed:8455624, PubMed:26159920). Predominantly nuclear protein in both unstressed and heat shocked cells (PubMed:10413683, PubMed:10359787). Translocates in the nucleus upon heat shock (PubMed:8455624). Nucleocytoplasmic shuttling protein (PubMed:26159920). Colocalizes with IER5 in the nucleus (PubMed:27354066). Colocalizes with BAG3 to the nucleus upon heat stress (PubMed:8455624, PubMed:26159920). Localizes in subnuclear granules called nuclear stress bodies (nSBs) upon heat shock (PubMed:11447121, PubMed:11514557, PubMed:10359787, PubMed:25963659, PubMed:10747973, PubMed:24581496, PubMed:19229036). Colocalizes with SYMPK and SUMO1 in nSBs upon heat shock (PubMed:11447121, PubMed:12665592, PubMed:11514557, PubMed:14707147, PubMed:10359787). Colocalizes with PRKACA/PKA in the nucleus and nSBs upon heat shock (PubMed:21085490). Relocalizes from the nucleus to the cytoplasm during the attenuation and recovery phase period of the heat shock response (PubMed:26159920). Translocates in the cytoplasm in a YWHAE- and XPO1/CRM1-dependent manner (PubMed:12917326). Together with histone H2AX, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) (PubMed:26359349). Colocalizes with calcium-responsive transactivator SS18L1 at kinetochore region on the mitotic chromosomes (PubMed:18794143). Colocalizes with gamma tubulin at centrosome (PubMed:18794143). Localizes at spindle pole in metaphase (PubMed:18794143). Colocalizes with PLK1 at spindle poles during prometaphase (PubMed:18794143). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:10413683, ECO:0000269|PubMed:10747973, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11514557, ECO:0000269|PubMed:12665592, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:24581496, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:27354066, ECO:0000269|PubMed:8455624}.
Q00653	reviewed	NFKB2_HUMAN	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]	NFKB2 LYT10	Homo sapiens (Human)	900	FUNCTION: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}.		canonical NF-kappaB signal transduction [GO:0007249]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; rhythmic process [GO:0048511]; spleen development [GO:0048536]	Bcl3/NF-kappaB2 complex [GO:0033257]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	Bcl3/NF-kappaB2 complex [GO:0033257]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; canonical NF-kappaB signal transduction [GO:0007249]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; rhythmic process [GO:0048511]; spleen development [GO:0048536]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Q00688	reviewed	FKBP3_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase)	FKBP3 FKBP25	Homo sapiens (Human)	224	FUNCTION: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.			nucleus [GO:0005634]	FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]	nucleus [GO:0005634]; FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]	SUBCELLULAR LOCATION: Nucleus.
Q00722	reviewed	PLCB2_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-2) (Phospholipase C-beta-2) (PLC-beta-2)	PLCB2	Homo sapiens (Human)	1185	FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:1644792, ECO:0000269|PubMed:9188725}.	MISCELLANEOUS: The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.	activation of phospholipase C activity [GO:0007202]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipid metabolic process [GO:0006644]; release of sequestered calcium ion into cytosol [GO:0051209]	cytosol [GO:0005829]; G-protein beta/gamma-subunit complex [GO:0031680]; neuronal dense core vesicle [GO:0098992]	calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; G-protein beta/gamma-subunit complex [GO:0031680]; neuronal dense core vesicle [GO:0098992]; calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; phospholipid binding [GO:0005543]; activation of phospholipase C activity [GO:0007202]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipid metabolic process [GO:0006644]; release of sequestered calcium ion into cytosol [GO:0051209]	
Q00765	reviewed	REEP5_HUMAN	Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2)	REEP5 C5orf18 DP1 TB2	Homo sapiens (Human)	189	FUNCTION: Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes. {ECO:0000250|UniProtKB:Q60870}.		endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum organization [GO:0007029]; regulation of intracellular transport [GO:0032386]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum tubular network [GO:0071782]; sarcoplasmic reticulum membrane [GO:0033017]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum tubular network [GO:0071782]; sarcoplasmic reticulum membrane [GO:0033017]; endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum organization [GO:0007029]; regulation of intracellular transport [GO:0032386]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23969831}; Multi-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q60870}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to endoplasmic reticulum tubular network (PubMed:23969831). In cardiomyocytes, localizes to the junctional sarcoplasmic reticulum membrane which is closely tethered to the cell membrane and contractile machinery (By similarity). {ECO:0000250|UniProtKB:Q60870, ECO:0000269|PubMed:23969831}.
Q00796	reviewed	DHSO_HUMAN	Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) ((R,R)-butanediol dehydrogenase) (EC 1.1.1.4) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Ribitol dehydrogenase) (RDH) (EC 1.1.1.56) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9)	SORD	Homo sapiens (Human)	357	FUNCTION: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively (PubMed:3365415). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia (PubMed:12962626, PubMed:29966615, PubMed:25105142). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (PubMed:16278369). May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor (PubMed:3365415). {ECO:0000269|PubMed:16278369, ECO:0000269|PubMed:3365415, ECO:0000303|PubMed:25105142, ECO:0000303|PubMed:29966615, ECO:0000305|PubMed:12962626}.		flagellated sperm motility [GO:0030317]; fructose biosynthetic process [GO:0046370]; glucose metabolic process [GO:0006006]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; L-xylitol catabolic process [GO:0051160]; L-xylitol metabolic process [GO:0051164]; sorbitol catabolic process [GO:0006062]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; motile cilium [GO:0031514]	(R,R)-butanediol dehydrogenase activity [GO:0000721]; carbohydrate binding [GO:0030246]; D-sorbitol dehydrogenase (acceptor) activity [GO:0047833]; D-xylulose reductase activity [GO:0046526]; identical protein binding [GO:0042802]; L-iditol 2-dehydrogenase activity [GO:0003939]; NAD binding [GO:0051287]; ribitol 2-dehydrogenase activity [GO:0050255]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; motile cilium [GO:0031514]; (R,R)-butanediol dehydrogenase activity [GO:0000721]; carbohydrate binding [GO:0030246]; D-sorbitol dehydrogenase (acceptor) activity [GO:0047833]; D-xylulose reductase activity [GO:0046526]; identical protein binding [GO:0042802]; L-iditol 2-dehydrogenase activity [GO:0003939]; NAD binding [GO:0051287]; ribitol 2-dehydrogenase activity [GO:0050255]; zinc ion binding [GO:0008270]; flagellated sperm motility [GO:0030317]; fructose biosynthetic process [GO:0046370]; glucose metabolic process [GO:0006006]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; L-xylitol catabolic process [GO:0051160]; L-xylitol metabolic process [GO:0051164]; sorbitol catabolic process [GO:0006062]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q64442}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64442}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q64442}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. {ECO:0000250|UniProtKB:Q64442}.
Q00839	reviewed	HNRPU_HUMAN	Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120)	HNRNPU C1orf199 HNRPU SAFA U21.1	Homo sapiens (Human)	825	FUNCTION: DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:8174554, PubMed:28622508). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:8174554, PubMed:9353307, PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Contributes also to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:7509195, PubMed:1324173, PubMed:9204873, PubMed:9405365, PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:28622508). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}.		adaptive thermogenesis [GO:1990845]; cardiac muscle cell development [GO:0055013]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; CRD-mediated mRNA stabilization [GO:0070934]; dendritic transport of messenger ribonucleoprotein complex [GO:0098963]; dosage compensation by inactivation of X chromosome [GO:0009048]; maintenance of protein location in nucleus [GO:0051457]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of kinase activity [GO:0033673]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; osteoblast differentiation [GO:0001649]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to spindle microtubule [GO:1902889]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of chromatin organization [GO:1902275]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic spindle assembly [GO:1901673]; RNA localization to chromatin [GO:1990280]; RNA processing [GO:0006396]	catalytic step 2 spliceosome [GO:0071013]; cell surface [GO:0009986]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; inactive sex chromosome [GO:0098577]; kinetochore [GO:0000776]; membrane [GO:0016020]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]; mitotic spindle midzone [GO:1990023]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; spindle pole [GO:0000922]; telomerase holoenzyme complex [GO:0005697]	actin binding [GO:0003779]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(C) RNA binding [GO:0017130]; poly(G) binding [GO:0034046]; pre-mRNA binding [GO:0036002]; promoter-specific chromatin binding [GO:1990841]; protein-containing complex binding [GO:0044877]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; snRNA binding [GO:0017069]; telomerase RNA binding [GO:0070034]; TFIIH-class transcription factor complex binding [GO:0001097]; transcription corepressor activity [GO:0003714]	catalytic step 2 spliceosome [GO:0071013]; cell surface [GO:0009986]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; inactive sex chromosome [GO:0098577]; kinetochore [GO:0000776]; membrane [GO:0016020]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]; mitotic spindle midzone [GO:1990023]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; spindle pole [GO:0000922]; telomerase holoenzyme complex [GO:0005697]; actin binding [GO:0003779]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(C) RNA binding [GO:0017130]; poly(G) binding [GO:0034046]; pre-mRNA binding [GO:0036002]; promoter-specific chromatin binding [GO:1990841]; protein-containing complex binding [GO:0044877]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; snRNA binding [GO:0017069]; telomerase RNA binding [GO:0070034]; TFIIH-class transcription factor complex binding [GO:0001097]; transcription corepressor activity [GO:0003714]; adaptive thermogenesis [GO:1990845]; cardiac muscle cell development [GO:0055013]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; CRD-mediated mRNA stabilization [GO:0070934]; dendritic transport of messenger ribonucleoprotein complex [GO:0098963]; dosage compensation by inactivation of X chromosome [GO:0009048]; maintenance of protein location in nucleus [GO:0051457]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of kinase activity [GO:0033673]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; osteoblast differentiation [GO:0001649]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to spindle microtubule [GO:1902889]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of chromatin organization [GO:1902275]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic spindle assembly [GO:1901673]; RNA localization to chromatin [GO:1990280]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:14608463, ECO:0000269|PubMed:15563465, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}. Nucleus matrix {ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:14608463, ECO:0000269|PubMed:8174554}. Chromosome {ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:14608463, ECO:0000269|PubMed:15563465}. Nucleus speckle {ECO:0000269|PubMed:9353307}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:25986610}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:21242313}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:25986610}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:21242313}. Midbody {ECO:0000269|PubMed:25986610}. Cytoplasm {ECO:0000269|PubMed:19029303}. Cell surface {ECO:0000269|PubMed:7993898}. Cytoplasmic granule {ECO:0000269|PubMed:17289661}. Note=Localizes at inactive X chromosome (Xi) regions (PubMed:11003645, PubMed:14608463, PubMed:15563465). Localizes in the nucleus during interphase (PubMed:21242313). At metaphase, localizes with mitotic spindle microtubules (MTs) (PubMed:21242313). At anaphase, localizes in the mitotic spindle midzone (PubMed:21242313). Localizes in spindle MTs proximal to spindle poles in a TPX2- and AURKA-dependent manner (PubMed:21242313). The Ser-59 phosphorylated form localizes to centrosomes during prophase and metaphase, to mitotic spindles in anaphase and to the midbody during cytokinesis (PubMed:25986610). Colocalizes with SMARCA4 in the nucleus (By similarity). Colocalizes with CBX5 in the nucleus (PubMed:19617346). Colocalizes with NR3C1 in nuclear speckles (PubMed:9353307). Localized in cytoplasmic ribonucleoprotein (RNP) granules containing untranslated mRNAs (PubMed:17289661). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:14608463, ECO:0000269|PubMed:15563465, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:9353307}.
Q00872	reviewed	MYPC1_HUMAN	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform)	MYBPC1 MYBPCS	Homo sapiens (Human)	1141	FUNCTION: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31264822, PubMed:31025394). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}.		cell adhesion [GO:0007155]	cytosol [GO:0005829]; myofibril [GO:0030016]; myosin filament [GO:0032982]	actin binding [GO:0003779]; myosin binding [GO:0017022]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]	cytosol [GO:0005829]; myofibril [GO:0030016]; myosin filament [GO:0032982]; actin binding [GO:0003779]; myosin binding [GO:0017022]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]; cell adhesion [GO:0007155]	
Q00887	reviewed	PSG9_HUMAN	Pregnancy-specific beta-1-glycoprotein 9 (PS-beta-G-9) (PSBG-9) (Pregnancy-specific glycoprotein 9) (PS34) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (Pregnancy-specific beta-1-glycoprotein 11) (PS-beta-G-11) (PSBG-11) (Pregnancy-specific glycoprotein 11) (Pregnancy-specific glycoprotein 7) (PSG7)	PSG9 PSG11	Homo sapiens (Human)	426	FUNCTION: Binds to the small latent transforming growth factor-beta complex, consisting of the N-terminal TGFB1 latency-associated peptide (LAP) and the mature form of TGFB1, thereby leading to the activation of TGFB1 (PubMed:27389696). The activation of TGFB1 leads to stimulation of naive CD4(+) T-cells to increase FoxP3 expression and to an increase in the number of FoxP3(+) regulatory T-cells (PubMed:27389696). Induces the differentiation of a suppressive CD4(+)LAP(+)FoxP3(-) T-cell subset (PubMed:27389696). Induces the secretion of TGFB1 in macrophages, but not in activated CD4(+) T-cells (PubMed:27389696). May reduce the expression of several pro-inflammatory cytokines and chemokines by CD4(+) T-cells, including IL2 and IL6 (PubMed:27389696). {ECO:0000269|PubMed:27389696}.		Fc receptor mediated inhibitory signaling pathway [GO:0002774]; female pregnancy [GO:0007565]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; positive regulation of gene expression [GO:0010628]; regulation of immune system process [GO:0002682]; regulation of regulatory T cell differentiation [GO:0045589]; signal transduction [GO:0007165]; tolerance induction dependent upon immune response [GO:0002461]; transforming growth factor beta receptor signaling pathway [GO:0007179]; transforming growth factor beta1 activation [GO:0036364]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; transforming growth factor beta ligand-receptor complex [GO:0070021]	protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; transforming growth factor beta ligand-receptor complex [GO:0070021]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; female pregnancy [GO:0007565]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; positive regulation of gene expression [GO:0010628]; regulation of immune system process [GO:0002682]; regulation of regulatory T cell differentiation [GO:0045589]; signal transduction [GO:0007165]; tolerance induction dependent upon immune response [GO:0002461]; transforming growth factor beta receptor signaling pathway [GO:0007179]; transforming growth factor beta1 activation [GO:0036364]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q00888	reviewed	PSG4_HUMAN	Pregnancy-specific beta-1-glycoprotein 4 (PS-beta-G-4) (PSBG-4) (Pregnancy-specific glycoprotein 4) (Pregnancy-specific beta-1-glycoprotein 9) (PS-beta-G-9) (PSBG-9) (Pregnancy-specific glycoprotein 9)	PSG4 CGM4 PSG9	Homo sapiens (Human)	419			female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	protein tyrosine kinase binding [GO:1990782]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein tyrosine kinase binding [GO:1990782]; female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q00889	reviewed	PSG6_HUMAN	Pregnancy-specific beta-1-glycoprotein 6 (PS-beta-G-6) (PSBG-6) (Pregnancy-specific glycoprotein 6) (Pregnancy-specific beta-1-glycoprotein 10) (PS-beta-G-10) (PSBG-10) (Pregnancy-specific glycoprotein 10) (Pregnancy-specific beta-1-glycoprotein 12) (PS-beta-G-12) (PSBG-12) (Pregnancy-specific glycoprotein 12)	PSG6 CGM3 PSG10 PSG12 PSGGB	Homo sapiens (Human)	435			female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	protein tyrosine kinase binding [GO:1990782]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein tyrosine kinase binding [GO:1990782]; female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q00973	reviewed	B4GN1_HUMAN	Beta-1,4 N-acetylgalactosaminyltransferase 1 (EC 2.4.1.92) ((N-acetylneuraminyl)-galactosylglucosylceramide) (GM2/GD2 synthase) (GalNAc-T)	B4GALNT1 GALGT SIAT2	Homo sapiens (Human)	533	FUNCTION: Involved in the biosynthesis of gangliosides GM2, GD2, GT2 and GA2 from GM3, GD3, GT3 and GA3, respectively. {ECO:0000269|PubMed:1601877, ECO:0000269|PubMed:7487055, ECO:0000269|PubMed:7890749}.		carbohydrate metabolic process [GO:0005975]; determination of adult lifespan [GO:0008340]; ganglioside biosynthetic process [GO:0001574]; glycosphingolipid metabolic process [GO:0006687]; limb development [GO:0060173]; lipid glycosylation [GO:0030259]; lipid storage [GO:0019915]; motor behavior [GO:0061744]; nerve development [GO:0021675]; spermatogenesis [GO:0007283]; vacuole organization [GO:0007033]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity [GO:0003947]; acetylgalactosaminyltransferase activity [GO:0008376]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity [GO:0003947]; acetylgalactosaminyltransferase activity [GO:0008376]; carbohydrate metabolic process [GO:0005975]; determination of adult lifespan [GO:0008340]; ganglioside biosynthetic process [GO:0001574]; glycosphingolipid metabolic process [GO:0006687]; limb development [GO:0060173]; lipid glycosylation [GO:0030259]; lipid storage [GO:0019915]; motor behavior [GO:0061744]; nerve development [GO:0021675]; spermatogenesis [GO:0007283]; vacuole organization [GO:0007033]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q10468}; Single-pass type II membrane protein {ECO:0000255}.
Q00975	reviewed	CAC1B_HUMAN	Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2)	CACNA1B CACH5 CACNL1A5	Homo sapiens (Human)	2339	FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). {ECO:0000250|UniProtKB:Q02294}.		calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to amyloid-beta [GO:1904645]	neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]	amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245]	neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]; amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245]; calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to amyloid-beta [GO:1904645]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:34234349}; Multi-pass membrane protein {ECO:0000269|PubMed:34234349}.
Q00978	reviewed	IRF9_HUMAN	Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)	IRF9 ISGF3G	Homo sapiens (Human)	393	FUNCTION: Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000269|PubMed:30143481}.		cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ISGF3 complex [GO:0070721]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ISGF3 complex [GO:0070721]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11846981}. Nucleus {ECO:0000269|PubMed:11846981, ECO:0000269|PubMed:30143481}. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
Q00987	reviewed	MDM2_HUMAN	E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)	MDM2	Homo sapiens (Human)	491	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}.	MISCELLANEOUS: MDM2 RING finger mutations that failed to ubiquitinate p53 in vitro did not target p53 for degradation when expressed in cells.; MISCELLANEOUS: [Isoform Mdm2-F]: Does not interact with p53/TP53. {ECO:0000305}.	amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; atrial septum development [GO:0003283]; atrioventricular valve morphogenesis [GO:0003181]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cardiac septum morphogenesis [GO:0060411]; cellular response to actinomycin D [GO:0072717]; cellular response to alkaloid [GO:0071312]; cellular response to estrogen stimulus [GO:0071391]; cellular response to gamma radiation [GO:0071480]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to UV-C [GO:0071494]; cellular response to vitamin B1 [GO:0071301]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endocardial cushion morphogenesis [GO:0003203]; establishment of protein localization [GO:0045184]; fibroblast activation [GO:0072537]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein processing [GO:0010955]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein localization to nucleus [GO:0034504]; protein polyubiquitination [GO:0000209]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of heart rate [GO:0002027]; regulation of protein catabolic process [GO:0042176]; response to antibiotic [GO:0046677]; response to cocaine [GO:0042220]; response to ether [GO:0045472]; response to formaldehyde [GO:1904404]; response to iron ion [GO:0010039]; response to magnesium ion [GO:0032026]; response to steroid hormone [GO:0048545]; response to toxic substance [GO:0009636]; response to water-immersion restraint stress [GO:1990785]; response to xenobiotic stimulus [GO:0009410]; traversing start control point of mitotic cell cycle [GO:0007089]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular septum development [GO:0003281]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053]	5S rRNA binding [GO:0008097]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ligase activity [GO:0016874]; NEDD8 ligase activity [GO:0061663]; p53 binding [GO:0002039]; peroxisome proliferator activated receptor binding [GO:0042975]; protein domain specific binding [GO:0019904]; receptor serine/threonine kinase binding [GO:0033612]; ribonucleoprotein complex binding [GO:0043021]; SUMO transferase activity [GO:0019789]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053]; 5S rRNA binding [GO:0008097]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ligase activity [GO:0016874]; NEDD8 ligase activity [GO:0061663]; p53 binding [GO:0002039]; peroxisome proliferator activated receptor binding [GO:0042975]; protein domain specific binding [GO:0019904]; receptor serine/threonine kinase binding [GO:0033612]; ribonucleoprotein complex binding [GO:0043021]; SUMO transferase activity [GO:0019789]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; atrial septum development [GO:0003283]; atrioventricular valve morphogenesis [GO:0003181]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cardiac septum morphogenesis [GO:0060411]; cellular response to actinomycin D [GO:0072717]; cellular response to alkaloid [GO:0071312]; cellular response to estrogen stimulus [GO:0071391]; cellular response to gamma radiation [GO:0071480]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to UV-C [GO:0071494]; cellular response to vitamin B1 [GO:0071301]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endocardial cushion morphogenesis [GO:0003203]; establishment of protein localization [GO:0045184]; fibroblast activation [GO:0072537]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein processing [GO:0010955]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein localization to nucleus [GO:0034504]; protein polyubiquitination [GO:0000209]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of heart rate [GO:0002027]; regulation of protein catabolic process [GO:0042176]; response to antibiotic [GO:0046677]; response to cocaine [GO:0042220]; response to ether [GO:0045472]; response to formaldehyde [GO:1904404]; response to iron ion [GO:0010039]; response to magnesium ion [GO:0032026]; response to steroid hormone [GO:0048545]; response to toxic substance [GO:0009636]; response to water-immersion restraint stress [GO:1990785]; response to xenobiotic stimulus [GO:0009410]; traversing start control point of mitotic cell cycle [GO:0007089]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm {ECO:0000269|PubMed:30879903}. Nucleus, nucleolus. Nucleus {ECO:0000269|PubMed:30879903}. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.
Q00994	reviewed	BEX3_HUMAN	Protein BEX3 (Brain-expressed X-linked protein 3) (Nerve growth factor receptor-associated protein 1) (Ovarian granulosa cell 13.0 kDa protein HGR74) (p75NTR-associated cell death executor)	BEX3 DXS6984E NADE NGFRAP1	Homo sapiens (Human)	111	FUNCTION: May be a signaling adapter molecule involved in NGFR/p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates. {ECO:0000250|UniProtKB:Q9WTZ9}.		extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of protein ubiquitination [GO:0031397]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; nerve growth factor receptor binding [GO:0005163]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; nerve growth factor receptor binding [GO:0005163]; signaling receptor binding [GO:0005102]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of protein ubiquitination [GO:0031397]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9WTZ9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9WTZ9}. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. {ECO:0000250|UniProtKB:Q9WTZ9}.
Q00G26	reviewed	PLIN5_HUMAN	Perilipin-5 (Lipid storage droplet protein 5)	PLIN5 LSDP5 OXPAT PAT-1	Homo sapiens (Human)	463	FUNCTION: Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). {ECO:0000250, ECO:0000269|PubMed:17234449}.		lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; mitochondrion localization [GO:0051646]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of lipase activity [GO:0060192]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of triglyceride catabolic process [GO:0010897]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of lipase activity [GO:0060193]; positive regulation of lipid storage [GO:0010884]; positive regulation of sequestering of triglyceride [GO:0010890]; positive regulation of triglyceride biosynthetic process [GO:0010867]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; mitochondrion [GO:0005739]	identical protein binding [GO:0042802]; lipase binding [GO:0035473]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; mitochondrion [GO:0005739]; identical protein binding [GO:0042802]; lipase binding [GO:0035473]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; mitochondrion localization [GO:0051646]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of lipase activity [GO:0060192]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of triglyceride catabolic process [GO:0010897]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of lipase activity [GO:0060193]; positive regulation of lipid storage [GO:0010884]; positive regulation of sequestering of triglyceride [GO:0010890]; positive regulation of triglyceride biosynthetic process [GO:0010867]	SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:17234449}. Cytoplasm {ECO:0000250|UniProtKB:Q8BVZ1}. Mitochondrion {ECO:0000250|UniProtKB:M0R7Z9}. Note=Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm. {ECO:0000250|UniProtKB:Q8BVZ1}.
Q00LT1	reviewed	PRCD_HUMAN	Photoreceptor disk component PRCD (Progressive rod-cone degeneration protein)	PRCD	Homo sapiens (Human)	54	FUNCTION: Involved in vision. {ECO:0000269|PubMed:16938425, ECO:0000269|PubMed:24992209}.		response to stimulus [GO:0050896]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; photoreceptor outer segment membrane [GO:0042622]	opsin binding [GO:0002046]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; photoreceptor outer segment membrane [GO:0042622]; opsin binding [GO:0002046]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:27613864}. Membrane {ECO:0000269|PubMed:27613864}; Lipid-anchor {ECO:0000269|PubMed:27613864}; Cytoplasmic side {ECO:0000250|UniProtKB:Q00LT2}. Endoplasmic reticulum {ECO:0000269|PubMed:24992209}. Golgi apparatus {ECO:0000269|PubMed:24992209}. Note=Localizes to photoreceptor disk membranes in the photoreceptor outer segment (PubMed:27613864). The secretion in media described in PubMed:24992209 is probably an experimental artifact (PubMed:24992209). {ECO:0000269|PubMed:24992209, ECO:0000269|PubMed:27613864}.
Q01064	reviewed	PDE1B_HUMAN	Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)	PDE1B PDES1B	Homo sapiens (Human)	536	FUNCTION: Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8855339, PubMed:9419816, PubMed:15260978). Has a preference for cGMP as a substrate (PubMed:9419816). {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:8855339, ECO:0000269|PubMed:9419816}.		cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; locomotory behavior [GO:0007626]; monocyte differentiation [GO:0030224]; regulation of dopamine metabolic process [GO:0042053]; regulation of neurotransmitter levels [GO:0001505]; response to amphetamine [GO:0001975]; serotonin metabolic process [GO:0042428]; signal transduction [GO:0007165]; visual learning [GO:0008542]	cytosol [GO:0005829]; neuronal cell body [GO:0043025]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin binding [GO:0005516]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; neuronal cell body [GO:0043025]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin binding [GO:0005516]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; locomotory behavior [GO:0007626]; monocyte differentiation [GO:0030224]; regulation of dopamine metabolic process [GO:0042053]; regulation of neurotransmitter levels [GO:0001505]; response to amphetamine [GO:0001975]; serotonin metabolic process [GO:0042428]; signal transduction [GO:0007165]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:8855339}.
Q01081	reviewed	U2AF1_HUMAN	Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit)	U2AF1 U2AF35 U2AFBP FP793	Homo sapiens (Human)	240	FUNCTION: Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269|PubMed:22158538, ECO:0000269|PubMed:25311244, ECO:0000269|PubMed:8647433}.	MISCELLANEOUS: [Isoform 2]: Interacts with U2AF2 and stimulates U2AF splicing activity in vitro. Less efficient than isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701]	metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]; RNA binding [GO:0003723]; RS domain binding [GO:0050733]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701]; metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]; RNA binding [GO:0003723]; RS domain binding [GO:0050733]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15096518}. Nucleus speckle {ECO:0000269|PubMed:15096518, ECO:0000269|PubMed:25311244}.
Q01082	reviewed	SPTB2_HUMAN	Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)	SPTBN1 SPTB2	Homo sapiens (Human)	2364	FUNCTION: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}.		actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; central nervous system development [GO:0007417]; central nervous system formation [GO:0021556]; Golgi to plasma membrane protein transport [GO:0043001]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; plasma membrane organization [GO:0007009]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of SMAD protein signal transduction [GO:0060390]	axolemma [GO:0030673]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; M band [GO:0031430]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; GTPase binding [GO:0051020]; phospholipid binding [GO:0005543]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]	axolemma [GO:0030673]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; M band [GO:0031430]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; GTPase binding [GO:0051020]; phospholipid binding [GO:0005543]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; central nervous system development [GO:0007417]; central nervous system formation [GO:0021556]; Golgi to plasma membrane protein transport [GO:0043001]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; plasma membrane organization [GO:0007009]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of SMAD protein signal transduction [GO:0060390]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q62261}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q62261}. Cytoplasm, cytosol {ECO:0000269|PubMed:34211179}. Cell membrane {ECO:0000269|PubMed:34211179}. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. {ECO:0000250|UniProtKB:Q62261}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Q01085	reviewed	TIAR_HUMAN	Nucleolysin TIAR (TIA-1-related protein)	TIAL1	Homo sapiens (Human)	375	FUNCTION: RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:1326761, PubMed:8576255, PubMed:17488725, PubMed:10613902). Shows a preference for uridine-rich RNAs (PubMed:8576255). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725). Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761). May be involved in apoptosis (PubMed:1326761). {ECO:0000250|UniProtKB:P70318, ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:1326761, ECO:0000269|PubMed:17488725, ECO:0000269|PubMed:8576255}.		apoptotic process [GO:0006915]; defense response [GO:0006952]; germ cell development [GO:0007281]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of hippo signaling [GO:0035332]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of stem cell proliferation [GO:2000648]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell division [GO:0017145]; stem cell proliferation [GO:0072089]	cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; protein-RNA adaptor activity [GO:0140517]; RNA binding [GO:0003723]	cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; protein-RNA adaptor activity [GO:0140517]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; defense response [GO:0006952]; germ cell development [GO:0007281]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of hippo signaling [GO:0035332]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of stem cell proliferation [GO:2000648]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell division [GO:0017145]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10613902}. Cytoplasm {ECO:0000250|UniProtKB:P70318}. Cytolytic granule {ECO:0000269|PubMed:1326761}. Cytoplasm, Stress granule {ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:18691976}. Note=Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity). Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902). {ECO:0000250|UniProtKB:P70318, ECO:0000269|PubMed:10613902}.
Q01094	reviewed	E2F1_HUMAN	Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)	E2F1 RBBP3	Homo sapiens (Human)	437	FUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17704056, PubMed:17050006, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:18625225, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:8170954}.		anoikis [GO:0043276]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage checkpoint signaling [GO:0000077]; DNA-templated transcription [GO:0006351]; forebrain development [GO:0030900]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lens fiber cell apoptotic process [GO:1990086]; mRNA stabilization [GO:0048255]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071930]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; Rb-E2F complex [GO:0035189]; RNA polymerase II transcription regulator complex [GO:0090575]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; molecular adaptor activity [GO:0060090]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; Rb-E2F complex [GO:0035189]; RNA polymerase II transcription regulator complex [GO:0090575]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; molecular adaptor activity [GO:0060090]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; anoikis [GO:0043276]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage checkpoint signaling [GO:0000077]; DNA-templated transcription [GO:0006351]; forebrain development [GO:0030900]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lens fiber cell apoptotic process [GO:1990086]; mRNA stabilization [GO:0048255]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071930]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:28992046}.
Q01101	reviewed	INSM1_HUMAN	Insulinoma-associated protein 1 (Zinc finger protein IA-1)	INSM1 IA1	Homo sapiens (Human)	510	FUNCTION: Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (PubMed:23721412). Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation. {ECO:0000269|PubMed:11842116, ECO:0000269|PubMed:16511571, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:19124461, ECO:0000269|PubMed:23721412}.		adrenal chromaffin cell differentiation [GO:0061104]; cell cycle [GO:0007049]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; noradrenergic neuron development [GO:0003358]; norepinephrine biosynthetic process [GO:0042421]; pancreatic A cell differentiation [GO:0003310]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of neural precursor cell proliferation [GO:2000179]; regulation of cell cycle [GO:0051726]; regulation of cell cycle process [GO:0010564]; regulation of gene expression [GO:0010468]; regulation of protein-containing complex assembly [GO:0043254]; sympathetic ganglion development [GO:0061549]; transdifferentiation [GO:0060290]; type B pancreatic cell development [GO:0003323]; type B pancreatic cell differentiation [GO:0003309]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	chromatin DNA binding [GO:0031490]; cyclin binding [GO:0030332]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; chromatin DNA binding [GO:0031490]; cyclin binding [GO:0030332]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; adrenal chromaffin cell differentiation [GO:0061104]; cell cycle [GO:0007049]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; noradrenergic neuron development [GO:0003358]; norepinephrine biosynthetic process [GO:0042421]; pancreatic A cell differentiation [GO:0003310]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of neural precursor cell proliferation [GO:2000179]; regulation of cell cycle [GO:0051726]; regulation of cell cycle process [GO:0010564]; regulation of gene expression [GO:0010468]; regulation of protein-containing complex assembly [GO:0043254]; sympathetic ganglion development [GO:0061549]; transdifferentiation [GO:0060290]; type B pancreatic cell development [GO:0003323]; type B pancreatic cell differentiation [GO:0003309]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q63ZV0}.
Q01105	reviewed	SET_HUMAN	Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I)	SET	Homo sapiens (Human)	290	FUNCTION: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}.		DNA replication [GO:0006260]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of histone acetylation [GO:0035067]; negative regulation of neuron apoptotic process [GO:0043524]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]; DNA replication [GO:0006260]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of histone acetylation [GO:0035067]; negative regulation of neuron apoptotic process [GO:0043524]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium.
Q01113	reviewed	IL9R_HUMAN	Interleukin-9 receptor (IL-9 receptor) (IL-9R) (CD antigen CD129)	IL9R	Homo sapiens (Human)	521	FUNCTION: Plays an important role in the immune response against parasites by acting as a receptor of IL9. {ECO:0000250|UniProtKB:Q01114}.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.	cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; interleukin-9-mediated signaling pathway [GO:0038113]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	interleukin-9 binding [GO:0019983]; interleukin-9 receptor activity [GO:0004919]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; interleukin-9 binding [GO:0019983]; interleukin-9 receptor activity [GO:0004919]; cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; interleukin-9-mediated signaling pathway [GO:0038113]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Secreted.
Q01118	reviewed	SCN7A_HUMAN	Sodium channel protein type 7 subunit alpha (Putative voltage-gated sodium channel subunit alpha Nax) (Sodium channel protein cardiac and skeletal muscle subunit alpha) (Sodium channel protein type VII subunit alpha)	SCN7A SCN6A	Homo sapiens (Human)	1682	FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. {ECO:0000305}.		calcium ion import across plasma membrane [GO:0098703]; cellular homeostasis [GO:0019725]; muscle contraction [GO:0006936]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to bacterium [GO:0009617]; sodium ion homeostasis [GO:0055078]; sodium ion transport [GO:0006814]	glial cell projection [GO:0097386]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]	high voltage-gated calcium channel activity [GO:0008331]; voltage-gated sodium channel activity [GO:0005248]	glial cell projection [GO:0097386]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated sodium channel activity [GO:0005248]; calcium ion import across plasma membrane [GO:0098703]; cellular homeostasis [GO:0019725]; muscle contraction [GO:0006936]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to bacterium [GO:0009617]; sodium ion homeostasis [GO:0055078]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:D0E0C2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}.
Q01130	reviewed	SRSF2_HUMAN	Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)	SRSF2 SFRS2	Homo sapiens (Human)	221	FUNCTION: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}.		mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21157427}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21157427}. Nucleus speckle {ECO:0000269|PubMed:21157427}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear speckle to nucleoplasm.
Q01151	reviewed	CD83_HUMAN	CD83 antigen (hCD83) (B-cell activation protein) (Cell surface protein HB15) (CD antigen CD83)	CD83	Homo sapiens (Human)	205	FUNCTION: May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.		CD4-positive, alpha-beta T cell differentiation [GO:0043367]; defense response [GO:0006952]; humoral immune response [GO:0006959]; negative regulation of interleukin-4 production [GO:0032713]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-2 production [GO:0032743]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]		external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; defense response [GO:0006952]; humoral immune response [GO:0006959]; negative regulation of interleukin-4 production [GO:0032713]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-2 production [GO:0032743]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q01167	reviewed	FOXK2_HUMAN	Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1)	FOXK2 ILF ILF1	Homo sapiens (Human)	660	FUNCTION: Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136}.		canonical glycolysis [GO:0061621]; intracellular glucose homeostasis [GO:0001678]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription by RNA polymerase II [GO:0006357]; response to starvation [GO:0042594]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; magnesium ion binding [GO:0000287]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; magnesium ion binding [GO:0000287]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; canonical glycolysis [GO:0061621]; intracellular glucose homeostasis [GO:0001678]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription by RNA polymerase II [GO:0006357]; response to starvation [GO:0042594]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20810654, ECO:0000269|PubMed:24748658, ECO:0000269|PubMed:25805136}. Cytoplasm {ECO:0000250|UniProtKB:Q3UCQ1}.
Q01196	reviewed	RUNX1_HUMAN	Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)	RUNX1 AML1 CBFA2	Homo sapiens (Human)	453	FUNCTION: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}.		cardiac muscle tissue regeneration [GO:0061026]; chondrocyte differentiation [GO:0002062]; hematopoietic stem cell proliferation [GO:0071425]; hemopoiesis [GO:0030097]; myeloid cell differentiation [GO:0030099]; myeloid leukocyte differentiation [GO:0002573]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; ossification [GO:0001503]; peripheral nervous system neuron development [GO:0048935]; positive regulation of angiogenesis [GO:0045766]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cell differentiation [GO:0045595]; regulation of connective tissue replacement [GO:1905203]; regulation of plasminogen activation [GO:0010755]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; core-binding factor complex [GO:0016513]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]	chromatin [GO:0000785]; core-binding factor complex [GO:0016513]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; cardiac muscle tissue regeneration [GO:0061026]; chondrocyte differentiation [GO:0002062]; hematopoietic stem cell proliferation [GO:0071425]; hemopoiesis [GO:0030097]; myeloid cell differentiation [GO:0030099]; myeloid leukocyte differentiation [GO:0002573]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; ossification [GO:0001503]; peripheral nervous system neuron development [GO:0048935]; positive regulation of angiogenesis [GO:0045766]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cell differentiation [GO:0045595]; regulation of connective tissue replacement [GO:1905203]; regulation of plasminogen activation [GO:0010755]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q01201	reviewed	RELB_HUMAN	Transcription factor RelB (I-Rel)	RELB	Homo sapiens (Human)	579	FUNCTION: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269|PubMed:1732739, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063, ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}.		antigen processing and presentation [GO:0019882]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to osmotic stress [GO:0071470]; circadian regulation of gene expression [GO:0032922]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lymphocyte differentiation [GO:0030098]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interferon-beta production [GO:0032688]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cytokine [GO:0034097]; T-helper 1 cell differentiation [GO:0045063]	chromatin [GO:0000785]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; NF-kappaB complex [GO:0071159]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; transcription repressor complex [GO:0017053]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; NF-kappaB complex [GO:0071159]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; transcription repressor complex [GO:0017053]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; antigen processing and presentation [GO:0019882]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to osmotic stress [GO:0071470]; circadian regulation of gene expression [GO:0032922]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lymphocyte differentiation [GO:0030098]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interferon-beta production [GO:0032688]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cytokine [GO:0034097]; T-helper 1 cell differentiation [GO:0045063]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20873783}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20873783}. Note=Colocalizes with NEK6 in the centrosome.
Q01344	reviewed	IL5RA_HUMAN	Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125)	IL5RA IL5R	Homo sapiens (Human)	420	FUNCTION: Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:9378992). Acts by forming an heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5 (PubMed:1495999, PubMed:22528658). In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:22528658, ECO:0000269|PubMed:9378992, ECO:0000269|PubMed:9516124}.		cytokine-mediated signaling pathway [GO:0019221]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-5-mediated signaling pathway [GO:0038043]; positive regulation of leukocyte proliferation [GO:0070665]; regulation of interleukin-5 production [GO:0032674]; signal transduction [GO:0007165]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-5 receptor activity [GO:0004914]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-5 receptor activity [GO:0004914]; cytokine-mediated signaling pathway [GO:0019221]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-5-mediated signaling pathway [GO:0038043]; positive regulation of leukocyte proliferation [GO:0070665]; regulation of interleukin-5 production [GO:0032674]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q01362	reviewed	FCERB_HUMAN	High affinity immunoglobulin epsilon receptor subunit beta (FcERI) (Fc epsilon receptor I beta-chain) (IgE Fc receptor subunit beta) (Membrane-spanning 4-domains subfamily A member 2)	MS4A2 APY FCER1B IGER	Homo sapiens (Human)	244	FUNCTION: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.		cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]	external side of plasma membrane [GO:0009897]; Fc-epsilon receptor I complex [GO:0032998]; plasma membrane [GO:0005886]	IgE binding [GO:0019863]	external side of plasma membrane [GO:0009897]; Fc-epsilon receptor I complex [GO:0032998]; plasma membrane [GO:0005886]; IgE binding [GO:0019863]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q01415	reviewed	GALK2_HUMAN	N-acetylgalactosamine kinase (EC 2.7.1.157) (GalNAc kinase) (Galactokinase 2)	GALK2 GK2	Homo sapiens (Human)	458	FUNCTION: Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates. {ECO:0000269|PubMed:16006554}.		carbohydrate metabolic process [GO:0005975]; galactose metabolic process [GO:0006012]	cytosol [GO:0005829]	ATP binding [GO:0005524]; galactokinase activity [GO:0004335]; N-acetylgalactosamine kinase activity [GO:0033858]	cytosol [GO:0005829]; ATP binding [GO:0005524]; galactokinase activity [GO:0004335]; N-acetylgalactosamine kinase activity [GO:0033858]; carbohydrate metabolic process [GO:0005975]; galactose metabolic process [GO:0006012]	
Q01432	reviewed	AMPD3_HUMAN	AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase)	AMPD3	Homo sapiens (Human)	767	FUNCTION: AMP deaminase plays a critical role in energy metabolism. {ECO:0000305|PubMed:9291127}.		AMP catabolic process [GO:0006196]; AMP metabolic process [GO:0046033]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]	AMP deaminase activity [GO:0003876]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; AMP deaminase activity [GO:0003876]; metal ion binding [GO:0046872]; AMP catabolic process [GO:0006196]; AMP metabolic process [GO:0046033]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264]	
Q01433	reviewed	AMPD2_HUMAN	AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L)	AMPD2	Homo sapiens (Human)	825	FUNCTION: AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. {ECO:0000269|PubMed:23911318}.		AMP metabolic process [GO:0046033]; cyclic purine nucleotide metabolic process [GO:0052652]; energy homeostasis [GO:0097009]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264]	cytosol [GO:0005829]	AMP deaminase activity [GO:0003876]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; AMP deaminase activity [GO:0003876]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; AMP metabolic process [GO:0046033]; cyclic purine nucleotide metabolic process [GO:0052652]; energy homeostasis [GO:0097009]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264]	
Q01449	reviewed	MLRA_HUMAN	Myosin regulatory light chain 2, atrial isoform (MLC-2a) (MLC2a) (Myosin light chain 2a) (Myosin regulatory light chain 7)	MYL7 MYL2A MYLC2A	Homo sapiens (Human)	175		MISCELLANEOUS: This chain binds calcium.	cardiac muscle tissue development [GO:0048738]; heart contraction [GO:0060047]	A band [GO:0031672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; myofibril [GO:0030016]; myosin complex [GO:0016459]	calcium ion binding [GO:0005509]	A band [GO:0031672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; myofibril [GO:0030016]; myosin complex [GO:0016459]; calcium ion binding [GO:0005509]; cardiac muscle tissue development [GO:0048738]; heart contraction [GO:0060047]	
Q01453	reviewed	PMP22_HUMAN	Peripheral myelin protein 22 (PMP-22) (Growth arrest-specific protein 3) (GAS-3)	PMP22 GAS3	Homo sapiens (Human)	160	FUNCTION: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.		apoptotic process [GO:0006915]; bleb assembly [GO:0032060]; cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; myelin assembly [GO:0032288]; negative regulation of neuron projection development [GO:0010977]; peripheral nervous system development [GO:0007422]	bicellular tight junction [GO:0005923]; compact myelin [GO:0043218]; plasma membrane [GO:0005886]; synapse [GO:0045202]		bicellular tight junction [GO:0005923]; compact myelin [GO:0043218]; plasma membrane [GO:0005886]; synapse [GO:0045202]; apoptotic process [GO:0006915]; bleb assembly [GO:0032060]; cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; myelin assembly [GO:0032288]; negative regulation of neuron projection development [GO:0010977]; peripheral nervous system development [GO:0007422]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21827951}; Multi-pass membrane protein {ECO:0000269|PubMed:21827951}.
Q01469	reviewed	FABP5_HUMAN	Fatty acid-binding protein 5 (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein, epidermal) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP)	FABP5	Homo sapiens (Human)	135	FUNCTION: Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058, PubMed:21395585). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987). {ECO:0000250|UniProtKB:Q05816, ECO:0000269|PubMed:21395585, ECO:0000269|PubMed:22170058, ECO:0000269|PubMed:8092987}.		epidermis development [GO:0008544]; fatty acid transport [GO:0015908]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid transport [GO:0015909]; negative regulation of glucose transmembrane transport [GO:0010829]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; regulation of prostaglandin biosynthetic process [GO:0031392]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]; regulation of sensory perception of pain [GO:0051930]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]	fatty acid binding [GO:0005504]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; long-chain fatty acid transporter activity [GO:0005324]; retinoic acid binding [GO:0001972]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; fatty acid binding [GO:0005504]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; long-chain fatty acid transporter activity [GO:0005324]; retinoic acid binding [GO:0001972]; epidermis development [GO:0008544]; fatty acid transport [GO:0015908]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid transport [GO:0015909]; negative regulation of glucose transmembrane transport [GO:0010829]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; regulation of prostaglandin biosynthetic process [GO:0031392]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]; regulation of sensory perception of pain [GO:0051930]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24692551, ECO:0000269|PubMed:8092987}. Nucleus {ECO:0000269|PubMed:24692551}. Synapse {ECO:0000250|UniProtKB:Q05816}. Postsynaptic density {ECO:0000250|UniProtKB:Q05816}. Secreted {ECO:0000250|UniProtKB:Q05816}. Note=Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (PubMed:24692551). Secreted by astrocytes, but not by neurons (By similarity). {ECO:0000250|UniProtKB:Q05816, ECO:0000269|PubMed:24692551}.
Q01484	reviewed	ANK2_HUMAN	Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)	ANK2 ANKB	Homo sapiens (Human)	3957	FUNCTION: Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}.		atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; endocytosis [GO:0006897]; intracellular calcium ion homeostasis [GO:0006874]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005]	A band [GO:0031672]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercalated disc [GO:0014704]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; Z disc [GO:0030018]	ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; phosphorylation-dependent protein binding [GO:0140031]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325]	A band [GO:0031672]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercalated disc [GO:0014704]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; Z disc [GO:0030018]; ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; phosphorylation-dependent protein binding [GO:0140031]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325]; atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; endocytosis [GO:0006897]; intracellular calcium ion homeostasis [GO:0006874]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19007774}. Membrane {ECO:0000269|PubMed:19007774}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q8C8R3}. Apical cell membrane {ECO:0000250|UniProtKB:Q8C8R3}. Cell membrane {ECO:0000269|PubMed:19007774}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q8C8R3}. Early endosome {ECO:0000250|UniProtKB:Q8C8R3}. Recycling endosome {ECO:0000250|UniProtKB:Q8C8R3}. Lysosome {ECO:0000250|UniProtKB:Q8C8R3}. Mitochondrion {ECO:0000250|UniProtKB:Q8C8R3}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q8C8R3}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:Q8C8R3}. Note=Expressed at the apical membrane of airway lung epithelial cells (By similarity). Localized to the plasma membrane of the inner segments of photoreceptors in retina. Colocalizes with SPTBN1 in a distinct intracellular compartment of neonatal cardiomyocytes (PubMed:19007774). In skeletal muscle, localizes to neuromuscular junctions (By similarity). Localizes with puncta at mitochondria ends. Colocalizes and cotransports on motile vesicles with RABGAP1L (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:19007774}.
Q01518	reviewed	CAP1_HUMAN	Adenylyl cyclase-associated protein 1 (CAP 1)	CAP1 CAP	Homo sapiens (Human)	475	FUNCTION: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.		actin filament organization [GO:0007015]; activation of adenylate cyclase activity [GO:0007190]; ameboidal-type cell migration [GO:0001667]; cAMP-mediated signaling [GO:0019933]; cell morphogenesis [GO:0000902]; establishment or maintenance of cell polarity [GO:0007163]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165]	azurophil granule lumen [GO:0035578]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; adenylate cyclase binding [GO:0008179]	azurophil granule lumen [GO:0035578]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; adenylate cyclase binding [GO:0008179]; actin filament organization [GO:0007015]; activation of adenylate cyclase activity [GO:0007190]; ameboidal-type cell migration [GO:0001667]; cAMP-mediated signaling [GO:0019933]; cell morphogenesis [GO:0000902]; establishment or maintenance of cell polarity [GO:0007163]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q01523	reviewed	DEF5_HUMAN	Defensin alpha 5 (Defensin-5) (HD5(20-94)) [Cleaved into: HD5(23-94); HD5(29-94); HD5(56-94); HD5(63-94)]	DEFA5 DEF5	Homo sapiens (Human)	94	FUNCTION: Host-defense peptide that maintains sterility in the urogenital system (PubMed:12021776, PubMed:12660734, PubMed:15616305, PubMed:22359618, PubMed:25354318, PubMed:30808760, PubMed:19589339, PubMed:22573326, PubMed:25782105). Has antimicrobial activity against a wide range of bacteria, including Gram-negative E.coli, P.aeruginosa and S.typhimurium, and Gram-positive E.aerogenes, S.aureus, B.cereus, E.faecium and L.monocytogenes (PubMed:12021776, PubMed:15616305, PubMed:22359618, PubMed:25354318, PubMed:30808760, PubMed:19589339, PubMed:22573326). Confers resistance to intestinal infection by S.typhimurium (PubMed:12660734). Exhibits antimicrobial activity against enteric commensal bacteria such as B.adolescentis, L.acidophilus, B.breve, L.fermentum, B.longum and S.thermophilus (PubMed:25354318). Binds to bacterial membranes and causes membrane disintegration (PubMed:25782105). Induces the secretion of the chemokine IL-8 by intestinal epithelial cells (PubMed:19589339). Binds to B.antracis lef/lethal factor, a major virulence factor from B.anthracis, and neutralizes its enzymatic activity (PubMed:22573326). {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:12660734, ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:19589339, ECO:0000269|PubMed:22359618, ECO:0000269|PubMed:22573326, ECO:0000269|PubMed:25354318, ECO:0000269|PubMed:25782105, ECO:0000269|PubMed:30808760}.; FUNCTION: (Microbial infection) Acts as a target for S.flexneri infection by binding to the bacterium, possibly via bacterial surface proteins, and thereby augmenting infectivity via enhanced bacterial adhesion and invasion of epithelial cells and tissues. {ECO:0000269|PubMed:29858013}.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]; perturbation of plasma membrane integrity in another organism [GO:0051673]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of membrane permeability [GO:1905710]; protein homotetramerization [GO:0051289]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; secretory granule [GO:0030141]; secretory granule lumen [GO:0034774]; transport vesicle [GO:0030133]	protein homodimerization activity [GO:0042803]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; secretory granule [GO:0030141]; secretory granule lumen [GO:0034774]; transport vesicle [GO:0030133]; protein homodimerization activity [GO:0042803]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]; perturbation of plasma membrane integrity in another organism [GO:0051673]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of membrane permeability [GO:1905710]; protein homotetramerization [GO:0051289]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:9588893}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:9588893}. Note=Stored as propeptide HD5(20-94) in secretory granules of small intestinal Paneth cells and found in the ileum lumen as processed mature peptides, predominantly in the HD5(63-94) form (PubMed:12021776). Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form (PubMed:12021776). Secreted into the female genital tract lumen (PubMed:9588893). {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:9588893}.
Q01524	reviewed	DEF6_HUMAN	Defensin-6 (Defensin, alpha 6)	DEFA6 DEF6	Homo sapiens (Human)	100	FUNCTION: Host-defense peptide that contributes to intestinal innate immunity and mediates homeostasis at mucosal surfaces by forming higher-order oligomers that capture bacteria and prevent microbial invasion of the epithelium (PubMed:15616305, PubMed:25158166, PubMed:25354318, PubMed:28026958, PubMed:17088326). After binding to bacterial surface proteins, undergoes ordered self-assembly to form fibril-like nanonets that surround and entangle bacteria and thereby prevent bacterial invasion across the epithelial barrier (PubMed:22722251). Entangles and agglutinates Gram-negative bacteria, such as E.coli, S.typhimurium and Y.enterocolitica, and Gram-positive bacteria such as L.monocytogenes, thereby protecting the intestine against invasion by enteric bacterial pathogens (PubMed:27076903, PubMed:25158166, PubMed:22722251). Blocks adhesion of C.albicans to intestinal epithelial cells and thereby suppresses fungal invasion of epithelial cells and biofilm formation (PubMed:28026958). Under reducing conditions and in an acidic environment similar to the intestinal milieu, exhibits inhibitory activity against anaerobic bacteria such as B.adolescentis, L.acidophilus and B.breve, as well as B.longum and S.thermophilus, possibly by leading to alterations in bacterial cell envelope structures (PubMed:25354318). The disulfide-linked oxidized form exhibits negligible antimicrobial activity against Gram-negative and Gram-positive bacteria, as compared to the enteric defensin DEFA5 (PubMed:15616305, PubMed:17088326). {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:17088326, ECO:0000269|PubMed:22722251, ECO:0000269|PubMed:25158166, ECO:0000269|PubMed:25354318, ECO:0000269|PubMed:27076903, ECO:0000269|PubMed:28026958}.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; killing of cells of another organism [GO:0031640]; perturbation of plasma membrane integrity in another organism [GO:0051673]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; transport vesicle [GO:0030133]	protein homodimerization activity [GO:0042803]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; transport vesicle [GO:0030133]; protein homodimerization activity [GO:0042803]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; killing of cells of another organism [GO:0031640]; perturbation of plasma membrane integrity in another organism [GO:0051673]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27076903}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:27076903}. Note=Stored as propeptide in secretory granules of small intestinal Paneth cells and found in the ileum lumen as mature peptide. {ECO:0000269|PubMed:27076903}.
Q01534	reviewed	TSPY1_HUMAN	Testis-specific Y-encoded protein 1 (Cancer/testis antigen 78) (CT78)	TSPY1 TSPY	Homo sapiens (Human)	308	FUNCTION: May be involved in sperm differentiation and proliferation. {ECO:0000269|PubMed:8923009}.		cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; sex differentiation [GO:0007548]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; sex differentiation [GO:0007548]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8923009}. Nucleus {ECO:0000269|PubMed:8923009}. Note=Predominantly cytoplasmic. Also found in nucleus.
Q01538	reviewed	MYT1_HUMAN	Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein)	MYT1 KIAA0835 KIAA1050 MTF1 MYTI PLPB1	Homo sapiens (Human)	1121	FUNCTION: Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}.		cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of DNA-templated transcription [GO:0006355]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus.
Q01543	reviewed	FLI1_HUMAN	Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB)	FLI1	Homo sapiens (Human)	452	FUNCTION: Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. {ECO:0000269|PubMed:24100448, ECO:0000269|PubMed:26316623, ECO:0000269|PubMed:28255014}.	MISCELLANEOUS: Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint.	animal organ morphogenesis [GO:0009887]; blood circulation [GO:0008015]; hemostasis [GO:0007599]; megakaryocyte development [GO:0035855]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; animal organ morphogenesis [GO:0009887]; blood circulation [GO:0008015]; hemostasis [GO:0007599]; megakaryocyte development [GO:0035855]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28255014}.
Q01546	reviewed	K22O_HUMAN	Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)	KRT76 KRT2B KRT2P	Homo sapiens (Human)	638	FUNCTION: Probably contributes to terminal cornification. {ECO:0000269|PubMed:1282112}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	cytoskeleton organization [GO:0007010]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; pigmentation [GO:0043473]; sebaceous gland development [GO:0048733]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; nucleus [GO:0005634]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; nucleus [GO:0005634]; structural constituent of skin epidermis [GO:0030280]; cytoskeleton organization [GO:0007010]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; pigmentation [GO:0043473]; sebaceous gland development [GO:0048733]	
Q01581	reviewed	HMCS1_HUMAN	Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)	HMGCS1 HMGCS	Homo sapiens (Human)	520	FUNCTION: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269|PubMed:7913309}.		acetyl-CoA metabolic process [GO:0006084]; cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; lipid metabolic process [GO:0006629]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	hydroxymethylglutaryl-CoA synthase activity [GO:0004421]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; hydroxymethylglutaryl-CoA synthase activity [GO:0004421]; protein homodimerization activity [GO:0042803]; acetyl-CoA metabolic process [GO:0006084]; cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:1358203}.
Q01628	reviewed	IFM3_HUMAN	Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Interferon-inducible protein 1-8U)	IFITM3	Homo sapiens (Human)	133	FUNCTION: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33270927, PubMed:33239446). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33270927). Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). Exerts opposing activities on SARS-CoV-2, including amphipathicity-dependent restriction of virus at endosomes and amphipathicity-independent enhancement of infection at the plasma membrane (PubMed:33270927). {ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22046135, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:23601107, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33239446, ECO:0000269|PubMed:33270927}.		defense response to virus [GO:0051607]; immune response [GO:0006955]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral transcription [GO:0032897]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]		early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; defense response to virus [GO:0051607]; immune response [GO:0006955]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral transcription [GO:0032897]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:22511783, ECO:0000269|PubMed:26354436}; Single-pass type II membrane protein {ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:22511783}. Late endosome membrane {ECO:0000269|PubMed:22046135}; Single-pass type II membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33270927}; Single-pass type II membrane protein. Lysosome membrane {ECO:0000269|PubMed:22046135, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33270927}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:30983867}. Note=Co-localizes with BRI3 isoform 1 at the perinuclear region. {ECO:0000269|PubMed:30983867}.
Q01629	reviewed	IFM2_HUMAN	Interferon-induced transmembrane protein 2 (Dispanin subfamily A member 2c) (DSPA2c) (Interferon-inducible protein 1-8D)	IFITM2	Homo sapiens (Human)	132	FUNCTION: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol (PubMed:33563656, PubMed:26354436). Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:33563656, PubMed:26354436, PubMed:33270927, PubMed:33239446). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33563656). Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). {ECO:0000269|PubMed:19544527, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33239446, ECO:0000269|PubMed:33270927, ECO:0000269|PubMed:33563656}.		cellular response to interferon-beta [GO:0035458]; defense response to virus [GO:0051607]; immune response [GO:0006955]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral genome replication [GO:0045071]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]		late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; cellular response to interferon-beta [GO:0035458]; defense response to virus [GO:0051607]; immune response [GO:0006955]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral genome replication [GO:0045071]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:33563656}; Single-pass type II membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:26354436}; Single-pass type II membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:26354436}; Single-pass type II membrane protein {ECO:0000305}.
Q01638	reviewed	ILRL1_HUMAN	Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Protein ST2)	IL1RL1 DER4 ST2 T1	Homo sapiens (Human)	556	FUNCTION: Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP (PubMed:35238669). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (PubMed:16286016) (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). {ECO:0000250|UniProtKB:P14719, ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:35238669, ECO:0000305|PubMed:19836339}.; FUNCTION: [Isoform B]: Inhibits IL-33 signaling. {ECO:0000250|UniProtKB:P14719}.	MISCELLANEOUS: [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-33-mediated signaling pathway [GO:0038172]; macrophage differentiation [GO:0030225]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of type II interferon production [GO:0032689]; positive regulation of chemokine production [GO:0032722]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of macrophage activation [GO:0043032]; signal transduction [GO:0007165]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	cytokine receptor activity [GO:0004896]; interleukin-1 receptor activity [GO:0004908]; interleukin-33 binding [GO:0002113]; interleukin-33 receptor activity [GO:0002114]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; cytokine receptor activity [GO:0004896]; interleukin-1 receptor activity [GO:0004908]; interleukin-33 binding [GO:0002113]; interleukin-33 receptor activity [GO:0002114]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-33-mediated signaling pathway [GO:0038172]; macrophage differentiation [GO:0030225]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of type II interferon production [GO:0032689]; positive regulation of chemokine production [GO:0032722]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of macrophage activation [GO:0043032]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform C]: Cell membrane.; SUBCELLULAR LOCATION: [Isoform B]: Secreted.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11478810}; Single-pass type I membrane protein {ECO:0000269|PubMed:11478810}.
Q01650	reviewed	LAT1_HUMAN	Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)	SLC7A5 CD98LC LAT1 MPE16	Homo sapiens (Human)	507	FUNCTION: The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanine (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10574970, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591, PubMed:18262359, PubMed:15769744). The heterodimer with SLC3A2 mediates the uptake of L-DOPA (By similarity). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity).Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744). {ECO:0000250|UniProtKB:Q63016, ECO:0000250|UniProtKB:Q9Z127, ECO:0000269|PubMed:10049700, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:18262359, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:9751058, ECO:0000305|PubMed:18262359}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.		alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; cellular response to glucose starvation [GO:0042149]; cellular response to L-arginine [GO:1903577]; cellular response to lipopolysaccharide [GO:0071222]; isoleucine transport [GO:0015818]; L-histidine transport [GO:1902024]; L-leucine import across plasma membrane [GO:1903801]; L-tryptophan transmembrane transport [GO:1904556]; leucine import across plasma membrane [GO:0098713]; leucine transport [GO:0015820]; liver regeneration [GO:0097421]; methionine transport [GO:0015821]; negative regulation of autophagy [GO:0010507]; negative regulation of gene expression [GO:0010629]; negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460]; neutral amino acid transport [GO:0015804]; phenylalanine transport [GO:0015823]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of leucine import across plasma membrane [GO:1905534]; positive regulation of type II interferon production [GO:0032729]; proline transport [GO:0015824]; response to hyperoxia [GO:0055093]; response to muscle activity [GO:0014850]; thyroid hormone transport [GO:0070327]; transport across blood-brain barrier [GO:0150104]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828]; valine transport [GO:0015829]; xenobiotic transport [GO:0042908]	amino acid transport complex [GO:1990184]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; aromatic amino acid transmembrane transporter activity [GO:0015173]; L-amino acid transmembrane transporter activity [GO:0015179]; L-leucine transmembrane transporter activity [GO:0015190]; L-tryptophan transmembrane transporter activity [GO:0015196]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; thyroid hormone transmembrane transporter activity [GO:0015349]	amino acid transport complex [GO:1990184]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; aromatic amino acid transmembrane transporter activity [GO:0015173]; L-amino acid transmembrane transporter activity [GO:0015179]; L-leucine transmembrane transporter activity [GO:0015190]; L-tryptophan transmembrane transporter activity [GO:0015196]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; thyroid hormone transmembrane transporter activity [GO:0015349]; alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; cellular response to glucose starvation [GO:0042149]; cellular response to L-arginine [GO:1903577]; cellular response to lipopolysaccharide [GO:0071222]; isoleucine transport [GO:0015818]; L-histidine transport [GO:1902024]; L-leucine import across plasma membrane [GO:1903801]; L-tryptophan transmembrane transport [GO:1904556]; leucine import across plasma membrane [GO:0098713]; leucine transport [GO:0015820]; liver regeneration [GO:0097421]; methionine transport [GO:0015821]; negative regulation of autophagy [GO:0010507]; negative regulation of gene expression [GO:0010629]; negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460]; neutral amino acid transport [GO:0015804]; phenylalanine transport [GO:0015823]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of leucine import across plasma membrane [GO:1905534]; positive regulation of type II interferon production [GO:0032729]; proline transport [GO:0015824]; response to hyperoxia [GO:0055093]; response to muscle activity [GO:0014850]; thyroid hormone transport [GO:0070327]; transport across blood-brain barrier [GO:0150104]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828]; valine transport [GO:0015829]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11742812}; Multi-pass membrane protein {ECO:0000269|PubMed:30867591}. Cell membrane {ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}; Multi-pass membrane protein {ECO:0000269|PubMed:30867591}. Lysosome membrane {ECO:0000269|PubMed:25998567}; Multi-pass membrane protein {ECO:0000305|PubMed:25998567}. Note=Located to the plasma membrane by SLC3A2/4F2hc (PubMed:9751058). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). {ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}.
Q01658	reviewed	NC2B_HUMAN	Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein)	DR1	Homo sapiens (Human)	176	FUNCTION: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; RNA polymerase II preinitiation complex assembly [GO:0051123]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; negative cofactor 2 complex [GO:0017054]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; negative cofactor 2 complex [GO:0017054]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus.
Q01664	reviewed	TFAP4_HUMAN	Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41)	TFAP4 BHLHC41	Homo sapiens (Human)	338	FUNCTION: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.		cellular response to dexamethasone stimulus [GO:0071549]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; protein-containing complex assembly [GO:0065003]; regulation of mitotic cell cycle phase transition [GO:1901990]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cellular response to dexamethasone stimulus [GO:0071549]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; protein-containing complex assembly [GO:0065003]; regulation of mitotic cell cycle phase transition [GO:1901990]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q01668	reviewed	CAC1D_HUMAN	Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Voltage-gated calcium channel subunit alpha Cav1.3)	CACNA1D CACH3 CACN4 CACNL1A2 CCHL1A2	Homo sapiens (Human)	2161	FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. {ECO:0000269|PubMed:18482979, ECO:0000269|PubMed:25620733, ECO:0000269|PubMed:28472301}.	MISCELLANEOUS: [Isoform 4]: Expressed at 5% to 15% of isoform Neuronal-type in brain tissues, increased current density. {ECO:0000305}.	adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cardiac muscle cell action potential involved in contraction [GO:0086002]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during SA node cell action potential [GO:0086046]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of calcium ion transport [GO:0051928]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; sensory perception of sound [GO:0007605]	L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018]	alpha-actinin binding [GO:0051393]; ankyrin binding [GO:0030506]; calcium channel activity [GO:0005262]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in cardiac muscle cell action potential [GO:0086007]; voltage-gated calcium channel activity involved SA node cell action potential [GO:0086059]	L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018]; alpha-actinin binding [GO:0051393]; ankyrin binding [GO:0030506]; calcium channel activity [GO:0005262]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in cardiac muscle cell action potential [GO:0086007]; voltage-gated calcium channel activity involved SA node cell action potential [GO:0086059]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cardiac muscle cell action potential involved in contraction [GO:0086002]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during SA node cell action potential [GO:0086046]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of calcium ion transport [GO:0051928]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:18482979}; Multi-pass membrane protein {ECO:0000269|PubMed:18482979}.
Q01718	reviewed	ACTHR_HUMAN	Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R)	MC2R ACTHR	Homo sapiens (Human)	297	FUNCTION: Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). {ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; regulation of metabolic process [GO:0019222]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	corticotropin receptor activity [GO:0004978]; G protein-coupled receptor activity [GO:0004930]; melanocortin receptor activity [GO:0004977]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; corticotropin receptor activity [GO:0004978]; G protein-coupled receptor activity [GO:0004930]; melanocortin receptor activity [GO:0004977]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; regulation of metabolic process [GO:0019222]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q01726	reviewed	MSHR_HUMAN	Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) (MC1-R)	MC1R MSHR	Homo sapiens (Human)	317	FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:1325670, PubMed:8463333, PubMed:1516719, PubMed:11442765, PubMed:11707265). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1325670, PubMed:11707265, PubMed:16463023, PubMed:19737927). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585). {ECO:0000269|PubMed:11442765, ECO:0000269|PubMed:11707265, ECO:0000269|PubMed:1325670, ECO:0000269|PubMed:1516719, ECO:0000269|PubMed:16463023, ECO:0000269|PubMed:19737927, ECO:0000269|PubMed:31097585, ECO:0000269|PubMed:8463333}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; intracellular signal transduction [GO:0035556]; melanin biosynthetic process [GO:0042438]; negative regulation of tumor necrosis factor production [GO:0032720]; pigmentation [GO:0043473]; positive regulation of feeding behavior [GO:2000253]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of metabolic process [GO:0019222]; sensory perception of pain [GO:0019233]; UV protection [GO:0009650]; UV-damage excision repair [GO:0070914]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; hormone binding [GO:0042562]; melanocortin receptor activity [GO:0004977]; melanocyte-stimulating hormone receptor activity [GO:0004980]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; hormone binding [GO:0042562]; melanocortin receptor activity [GO:0004977]; melanocyte-stimulating hormone receptor activity [GO:0004980]; ubiquitin protein ligase binding [GO:0031625]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; intracellular signal transduction [GO:0035556]; melanin biosynthetic process [GO:0042438]; negative regulation of tumor necrosis factor production [GO:0032720]; pigmentation [GO:0043473]; positive regulation of feeding behavior [GO:2000253]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of metabolic process [GO:0019222]; sensory perception of pain [GO:0019233]; UV protection [GO:0009650]; UV-damage excision repair [GO:0070914]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31097585}; Multi-pass membrane protein {ECO:0000255}.
Q01740	reviewed	FMO1_HUMAN	Flavin-containing monooxygenase 1 (EC 1.14.13.148) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 1) (Dimethylaniline oxidase 1) (Fetal hepatic flavin-containing monooxygenase 1) (FMO 1) (Trimethylamine monooxygenase)	FMO1	Homo sapiens (Human)	532	FUNCTION: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (PubMed:32156684). Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (PubMed:32156684). In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (By similarity). {ECO:0000250|UniProtKB:P36365, ECO:0000269|PubMed:32156684}.		energy homeostasis [GO:0097009]; NADPH oxidation [GO:0070995]; negative regulation of fatty acid oxidation [GO:0046322]; organic acid metabolic process [GO:0006082]; response to lipopolysaccharide [GO:0032496]; sulfur amino acid catabolic process [GO:0000098]; taurine biosynthetic process [GO:0042412]; toxin metabolic process [GO:0009404]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]	flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]; energy homeostasis [GO:0097009]; NADPH oxidation [GO:0070995]; negative regulation of fatty acid oxidation [GO:0046322]; organic acid metabolic process [GO:0006082]; response to lipopolysaccharide [GO:0032496]; sulfur amino acid catabolic process [GO:0000098]; taurine biosynthetic process [GO:0042412]; toxin metabolic process [GO:0009404]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P36365}; Single-pass membrane protein {ECO:0000255}.
Q01780	reviewed	EXOSX_HUMAN	Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2)	EXOSC10 PMSCL PMSCL2 RRP6	Homo sapiens (Human)	885	FUNCTION: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. {ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273, ECO:0000269|PubMed:34516797}.		CUT catabolic process [GO:0071034]; dosage compensation by inactivation of X chromosome [GO:0009048]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent antisense transcript catabolic process [GO:0071040]; nuclear polyadenylation-dependent CUT catabolic process [GO:0071039]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent snoRNA catabolic process [GO:0071036]; nuclear polyadenylation-dependent snRNA catabolic process [GO:0071037]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; ribosomal small subunit biogenesis [GO:0042274]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; membrane [GO:0016020]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]	3'-5'-RNA exonuclease activity [GO:0000175]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; RNA exonuclease activity [GO:0004532]; single-stranded RNA binding [GO:0003727]; telomerase RNA binding [GO:0070034]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; membrane [GO:0016020]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; 3'-5'-RNA exonuclease activity [GO:0000175]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; RNA exonuclease activity [GO:0004532]; single-stranded RNA binding [GO:0003727]; telomerase RNA binding [GO:0070034]; CUT catabolic process [GO:0071034]; dosage compensation by inactivation of X chromosome [GO:0009048]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent antisense transcript catabolic process [GO:0071040]; nuclear polyadenylation-dependent CUT catabolic process [GO:0071039]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent snoRNA catabolic process [GO:0071036]; nuclear polyadenylation-dependent snRNA catabolic process [GO:0071037]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; ribosomal small subunit biogenesis [GO:0042274]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.
Q01804	reviewed	OTUD4_HUMAN	OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1)	OTUD4 HIN-1 KIAA1046	Homo sapiens (Human)	1114	FUNCTION: Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}.	MISCELLANEOUS: [Isoform 4]: Predicted from a chimeric transcript isolated from HIV-1-infected cells. The premature stop may be due to intron retention. {ECO:0000305}.	innate immune response [GO:0045087]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of DNA demethylation [GO:1901537]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of protein K48-linked deubiquitination [GO:1903093]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578]; molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578]; molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723]; innate immune response [GO:0045087]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of DNA demethylation [GO:1901537]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of protein K48-linked deubiquitination [GO:1903093]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25944111}. Nucleus {ECO:0000269|PubMed:25944111}. Note=Primarily cytoplasmic. {ECO:0000269|PubMed:25944111}.
Q01813	reviewed	PFKAP_HUMAN	ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)	PFKP PFKF	Homo sapiens (Human)	784	FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.	MISCELLANEOUS: In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes.	canonical glycolysis [GO:0061621]; cellular response to leukemia inhibitory factor [GO:1990830]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]	6-phosphofructokinase complex [GO:0005945]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]	6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]; protein-containing complex binding [GO:0044877]	6-phosphofructokinase complex [GO:0005945]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; 6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]; protein-containing complex binding [GO:0044877]; canonical glycolysis [GO:0061621]; cellular response to leukemia inhibitory factor [GO:1990830]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
Q01814	reviewed	AT2B2_HUMAN	Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2)	ATP2B2 PMCA2	Homo sapiens (Human)	1243	FUNCTION: ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:15829536). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:17234811, PubMed:15829536). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:17234811, PubMed:15829536). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:17234811, PubMed:15829536). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}.		calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; neural retina development [GO:0003407]; neuron differentiation [GO:0030182]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]; sensory perception of sound [GO:0007605]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; dendritic spine membrane [GO:0032591]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body membrane [GO:0032809]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; glutamate receptor binding [GO:0035254]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:1905059]; PDZ domain binding [GO:0030165]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; dendritic spine membrane [GO:0032591]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body membrane [GO:0032809]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; glutamate receptor binding [GO:0035254]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:1905059]; PDZ domain binding [GO:0030165]; calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; neural retina development [GO:0003407]; neuron differentiation [GO:0030182]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17234811}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q9R0K7}.; SUBCELLULAR LOCATION: [Isoform WA]: Apical cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform WB]: Apical cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform XB]: Basolateral cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform ZA]: Basolateral cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform ZB]: Basolateral cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}.
Q01826	reviewed	SATB1_HUMAN	DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1)	SATB1	Homo sapiens (Human)	763	FUNCTION: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}.		chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:10800076, ECO:0000269|PubMed:18408014}. Nucleus, PML body {ECO:0000269|PubMed:18408014}. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences (PubMed:12692553). When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:18408014). {ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:18408014}.
Q01831	reviewed	XPC_HUMAN	DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125)	XPC XPCC	Homo sapiens (Human)	940	FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:19609301, PubMed:20649465, PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}.		DNA repair [GO:0006281]; mismatch repair [GO:0006298]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA-templated transcription [GO:0045893]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to auditory stimulus [GO:0010996]; response to UV-B [GO:0010224]; response to xenobiotic stimulus [GO:0009410]; UV-damage excision repair [GO:0070914]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 2 complex [GO:0000111]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of DNA damage [GO:0090734]; XPC complex [GO:0071942]	bubble DNA binding [GO:0000405]; damaged DNA binding [GO:0003684]; DNA damage sensor activity [GO:0140612]; heteroduplex DNA loop binding [GO:0000404]; protein-containing complex binding [GO:0044877]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 2 complex [GO:0000111]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of DNA damage [GO:0090734]; XPC complex [GO:0071942]; bubble DNA binding [GO:0000405]; damaged DNA binding [GO:0003684]; DNA damage sensor activity [GO:0140612]; heteroduplex DNA loop binding [GO:0000404]; protein-containing complex binding [GO:0044877]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713]; DNA repair [GO:0006281]; mismatch repair [GO:0006298]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA-templated transcription [GO:0045893]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to auditory stimulus [GO:0010996]; response to UV-B [GO:0010224]; response to xenobiotic stimulus [GO:0009410]; UV-damage excision repair [GO:0070914]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11279143, ECO:0000269|PubMed:18682493, ECO:0000269|PubMed:8692695}. Chromosome {ECO:0000269|PubMed:29973595}. Cytoplasm {ECO:0000269|PubMed:18682493}. Note=Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage (PubMed:18682493). Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions (PubMed:18682493). {ECO:0000269|PubMed:18682493}.
Q01844	reviewed	EWS_HUMAN	RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)	EWSR1 EWS	Homo sapiens (Human)	656	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.			Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16965792}. Cytoplasm {ECO:0000269|PubMed:16965792}. Cell membrane {ECO:0000269|PubMed:16965792}. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.
Q01850	reviewed	CDR2_HUMAN	Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen)	CDR2 PCD17	Homo sapiens (Human)	454				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q01851	reviewed	PO4F1_HUMAN	POU domain, class 4, transcription factor 1 (Brain-specific homeobox/POU domain protein 3A) (Brain-3A) (Brn-3A) (Homeobox/POU domain protein RDC-1) (Oct-T1)	POU4F1 BRN3A RDC1	Homo sapiens (Human)	419	FUNCTION: Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site. {ECO:0000250|UniProtKB:P17208}.; FUNCTION: [Isoform 2]: Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have antiapoptotic effect on neuronal cells. {ECO:0000250|UniProtKB:P17208}.		axonogenesis [GO:0007409]; cell migration in hindbrain [GO:0021535]; cellular response to cytokine stimulus [GO:0071345]; cellular response to estradiol stimulus [GO:0071392]; central nervous system neuron differentiation [GO:0021953]; habenula development [GO:0021986]; heart development [GO:0007507]; innervation [GO:0060384]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; mesoderm development [GO:0007498]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; neuron fate specification [GO:0048665]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; peripheral nervous system neuron development [GO:0048935]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; proprioception involved in equilibrioception [GO:0051355]; regulation of cell cycle [GO:0051726]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory system development [GO:0048880]; suckling behavior [GO:0001967]; synapse assembly [GO:0007416]; trigeminal nerve development [GO:0021559]; ventricular compact myocardium morphogenesis [GO:0003223]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; GTPase binding [GO:0051020]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; GTPase binding [GO:0051020]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded DNA binding [GO:0003697]; axonogenesis [GO:0007409]; cell migration in hindbrain [GO:0021535]; cellular response to cytokine stimulus [GO:0071345]; cellular response to estradiol stimulus [GO:0071392]; central nervous system neuron differentiation [GO:0021953]; habenula development [GO:0021986]; heart development [GO:0007507]; innervation [GO:0060384]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; mesoderm development [GO:0007498]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; neuron fate specification [GO:0048665]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; peripheral nervous system neuron development [GO:0048935]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; proprioception involved in equilibrioception [GO:0051355]; regulation of cell cycle [GO:0051726]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory system development [GO:0048880]; suckling behavior [GO:0001967]; synapse assembly [GO:0007416]; trigeminal nerve development [GO:0021559]; ventricular compact myocardium morphogenesis [GO:0003223]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12934100}. Cytoplasm {ECO:0000250|UniProtKB:P17208}.
Q01860	reviewed	PO5F1_HUMAN	POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3)	POU5F1 OCT3 OCT4 OTF3	Homo sapiens (Human)	360	FUNCTION: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269|PubMed:18035408}.	MISCELLANEOUS: Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them, localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.	anatomical structure morphogenesis [GO:0009653]; blastocyst development [GO:0001824]; BMP signaling pathway [GO:0030509]; cardiac cell fate determination [GO:0060913]; cell fate commitment involved in formation of primary germ layer [GO:0060795]; endodermal cell fate specification [GO:0001714]; endodermal-mesodermal cell signaling [GO:0003133]; heart induction [GO:0003129]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of asymmetric cell division [GO:0009786]; regulation of canonical Wnt signaling pathway involved in heart development [GO:1905066]; regulation of DNA methylation-dependent heterochromatin formation [GO:0090308]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to wounding [GO:0009611]; somatic stem cell population maintenance [GO:0035019]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; anatomical structure morphogenesis [GO:0009653]; blastocyst development [GO:0001824]; BMP signaling pathway [GO:0030509]; cardiac cell fate determination [GO:0060913]; cell fate commitment involved in formation of primary germ layer [GO:0060795]; endodermal cell fate specification [GO:0001714]; endodermal-mesodermal cell signaling [GO:0003133]; heart induction [GO:0003129]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of asymmetric cell division [GO:0009786]; regulation of canonical Wnt signaling pathway involved in heart development [GO:1905066]; regulation of DNA methylation-dependent heterochromatin formation [GO:0090308]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to wounding [GO:0009611]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern. Colocalizes with MAPK8 and MAPK9 in the nucleus. {ECO:0000250|UniProtKB:P20263, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:23024368}.
Q01892	reviewed	SPIB_HUMAN	Transcription factor Spi-B	SPIB	Homo sapiens (Human)	262	FUNCTION: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. {ECO:0000269|PubMed:10196196, ECO:0000269|PubMed:12393575, ECO:0000269|PubMed:1406622, ECO:0000269|PubMed:15583020}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:12393575}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:12393575}.
Q01954	reviewed	BNC1_HUMAN	Zinc finger protein basonuclin-1	BNC1 BNC	Homo sapiens (Human)	994	FUNCTION: Transcriptional activator (By similarity). It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (PubMed:8034748). Required for the maintenance of spermatogenesis (By similarity). It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (PubMed:30010909). May also play a role in the early development of embryos (By similarity). {ECO:0000250|UniProtKB:O35914, ECO:0000269|PubMed:30010909, ECO:0000269|PubMed:8034748}.		cell differentiation [GO:0030154]; epidermis development [GO:0008544]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of oocyte maturation [GO:1900195]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of transcription by RNA polymerase I [GO:0006356]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity [GO:0001216]; metal ion binding [GO:0046872]; rDNA binding [GO:0000182]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity [GO:0001216]; metal ion binding [GO:0046872]; rDNA binding [GO:0000182]; cell differentiation [GO:0030154]; epidermis development [GO:0008544]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of oocyte maturation [GO:1900195]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of transcription by RNA polymerase I [GO:0006356]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16891417, ECO:0000269|PubMed:30010909, ECO:0000269|PubMed:8034748, ECO:0000269|PubMed:9223293}. Cytoplasm {ECO:0000269|PubMed:9223293}. Nucleus, nucleoplasm {ECO:0000269|PubMed:16891417}. Note=Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids. {ECO:0000250|UniProtKB:O35914}.
Q01955	reviewed	CO4A3_HUMAN	Collagen alpha-3(IV) chain (Goodpasture antigen) [Cleaved into: Tumstatin]	COL4A3	Homo sapiens (Human)	1670	FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.	MISCELLANEOUS: The epitopes recognized by the Goodpasture autoantibodies are sequestered within the NC1 hexamer of the type IV collagen network.	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; blood circulation [GO:0008015]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; endothelial cell apoptotic process [GO:0072577]; extracellular matrix organization [GO:0030198]; glomerular basement membrane development [GO:0032836]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; response to glucose [GO:0009749]; sensory perception of sound [GO:0007605]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; integrin binding [GO:0005178]; metalloendopeptidase inhibitor activity [GO:0008191]; structural molecule activity [GO:0005198]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; integrin binding [GO:0005178]; metalloendopeptidase inhibitor activity [GO:0008191]; structural molecule activity [GO:0005198]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; blood circulation [GO:0008015]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; endothelial cell apoptotic process [GO:0072577]; extracellular matrix organization [GO:0030198]; glomerular basement membrane development [GO:0032836]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; response to glucose [GO:0009749]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). {ECO:0000250}.
Q01959	reviewed	SC6A3_HUMAN	Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3)	SLC6A3 DAT1	Homo sapiens (Human)	620	FUNCTION: Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1406597, PubMed:8302271, PubMed:10375632, PubMed:11093780, PubMed:15505207, PubMed:19478460). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). {ECO:0000250|UniProtKB:P23977, ECO:0000250|UniProtKB:Q61327, ECO:0000269|PubMed:1406597, ECO:0000269|PubMed:15505207, ECO:0000269|PubMed:8302271}.	MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.	adenohypophysis development [GO:0021984]; dopamine biosynthetic process [GO:0042416]; dopamine catabolic process [GO:0042420]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; dopamine uptake involved in synaptic transmission [GO:0051583]; hyaloid vascular plexus regression [GO:1990384]; lactation [GO:0007595]; locomotory behavior [GO:0007626]; monoamine transport [GO:0015844]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; positive regulation of multicellular organism growth [GO:0040018]; prepulse inhibition [GO:0060134]; regulation of dopamine metabolic process [GO:0042053]; response to cAMP [GO:0051591]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to iron ion [GO:0010039]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410]; sensory perception of smell [GO:0007608]; sodium ion transmembrane transport [GO:0035725]	axon [GO:0030424]; axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dopaminergic synapse [GO:0098691]; flotillin complex [GO:0016600]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	amine binding [GO:0043176]; dopamine binding [GO:0035240]; dopamine:sodium symporter activity [GO:0005330]; heterocyclic compound binding [GO:1901363]; metal ion binding [GO:0046872]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; norepinephrine:sodium symporter activity [GO:0005334]; protease binding [GO:0002020]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]	axon [GO:0030424]; axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dopaminergic synapse [GO:0098691]; flotillin complex [GO:0016600]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; amine binding [GO:0043176]; dopamine binding [GO:0035240]; dopamine:sodium symporter activity [GO:0005330]; heterocyclic compound binding [GO:1901363]; metal ion binding [GO:0046872]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; norepinephrine:sodium symporter activity [GO:0005334]; protease binding [GO:0002020]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; adenohypophysis development [GO:0021984]; dopamine biosynthetic process [GO:0042416]; dopamine catabolic process [GO:0042420]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; dopamine uptake involved in synaptic transmission [GO:0051583]; hyaloid vascular plexus regression [GO:1990384]; lactation [GO:0007595]; locomotory behavior [GO:0007626]; monoamine transport [GO:0015844]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; positive regulation of multicellular organism growth [GO:0040018]; prepulse inhibition [GO:0060134]; regulation of dopamine metabolic process [GO:0042053]; response to cAMP [GO:0051591]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to iron ion [GO:0010039]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410]; sensory perception of smell [GO:0007608]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11343649, ECO:0000269|PubMed:15505207}; Multi-pass membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P23977}. Cell projection, axon {ECO:0000269|PubMed:17296554}. Note=Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:P23977, ECO:0000250|UniProtKB:Q61327}.
Q01968	reviewed	OCRL_HUMAN	Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)	OCRL OCRL1	Homo sapiens (Human)	901	FUNCTION: Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:7761412, PubMed:15474001, PubMed:9430698, PubMed:10764818). Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:7761412, PubMed:25869668). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788). {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:15474001, ECO:0000269|PubMed:21971085, ECO:0000269|PubMed:22072788, ECO:0000269|PubMed:22228094, ECO:0000269|PubMed:22543976, ECO:0000269|PubMed:25869668, ECO:0000269|PubMed:7761412, ECO:0000269|PubMed:9430698}.		cilium assembly [GO:0060271]; in utero embryonic development [GO:0001701]; inositol phosphate metabolic process [GO:0043647]; lipid metabolic process [GO:0006629]; membrane organization [GO:0061024]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; signal transduction [GO:0007165]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi stack [GO:0005795]; Golgi-associated vesicle [GO:0005798]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; phagocytic vesicle membrane [GO:0030670]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GTPase activator activity [GO:0005096]; inositol phosphate phosphatase activity [GO:0052745]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; small GTPase binding [GO:0031267]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi stack [GO:0005795]; Golgi-associated vesicle [GO:0005798]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; phagocytic vesicle membrane [GO:0030670]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; GTPase activator activity [GO:0005096]; inositol phosphate phosphatase activity [GO:0052745]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; small GTPase binding [GO:0031267]; cilium assembly [GO:0060271]; in utero embryonic development [GO:0001701]; inositol phosphate metabolic process [GO:0043647]; lipid metabolic process [GO:0006629]; membrane organization [GO:0061024]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:D3ZGS3}. Early endosome membrane {ECO:0000269|PubMed:21971085, ECO:0000269|PubMed:25869668}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:25869668}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:22543976}. Cell projection, cilium {ECO:0000269|PubMed:22543976}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:D3ZGS3}. Endosome {ECO:0000269|PubMed:21971085, ECO:0000269|PubMed:25869668}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:D3ZGS3}. Lysosome {ECO:0000269|PubMed:9430698}. Note=Also found on macropinosomes (PubMed:25869668). Colocalized with APPL1 on phagosomes (PubMed:22072788). {ECO:0000269|PubMed:22072788, ECO:0000269|PubMed:25869668}.
Q01970	reviewed	PLCB3_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3)	PLCB3	Homo sapiens (Human)	1234	FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:9188725}.		G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; regulation of systemic arterial blood pressure [GO:0003073]; release of sequestered calcium ion into cytosol [GO:0051209]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; protein-containing complex [GO:0032991]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; protein-containing complex [GO:0032991]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; regulation of systemic arterial blood pressure [GO:0003073]; release of sequestered calcium ion into cytosol [GO:0051209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29122926}. Membrane {ECO:0000250|UniProtKB:Q99JE6}. Nucleus {ECO:0000250|UniProtKB:P51432}. Note=And particulate fractions. {ECO:0000250|UniProtKB:Q99JE6}.
Q01973	reviewed	ROR1_HUMAN	Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1)	ROR1 NTRKR1	Homo sapiens (Human)	937	FUNCTION: Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). {ECO:0000269|PubMed:25029443, ECO:0000269|PubMed:27162350}.		astrocyte development [GO:0014002]; inner ear development [GO:0048839]; phosphorylation [GO:0016310]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; sensory perception of sound [GO:0007605]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; stress fiber [GO:0001725]	ATP binding [GO:0005524]; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; stress fiber [GO:0001725]; ATP binding [GO:0005524]; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; astrocyte development [GO:0014002]; inner ear development [GO:0048839]; phosphorylation [GO:0016310]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; sensory perception of sound [GO:0007605]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:27162350}; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z139}.
Q01974	reviewed	ROR2_HUMAN	Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)	ROR2 NTRKR2	Homo sapiens (Human)	943	FUNCTION: Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). {ECO:0000250|UniProtKB:Q9Z138, ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:25029443}.		astrocyte development [GO:0014002]; bone mineralization [GO:0030282]; macrophage migration [GO:1905517]; male genitalia development [GO:0030539]; phosphorylation [GO:0016310]; positive regulation of cell migration [GO:0030335]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic signaling by nitric oxide [GO:0150045]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]; metal ion binding [GO:0046872]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]; metal ion binding [GO:0046872]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; Wnt-protein binding [GO:0017147]; astrocyte development [GO:0014002]; bone mineralization [GO:0030282]; macrophage migration [GO:1905517]; male genitalia development [GO:0030539]; phosphorylation [GO:0016310]; positive regulation of cell migration [GO:0030335]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic signaling by nitric oxide [GO:0150045]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q02040	reviewed	AK17A_HUMAN	A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A)	AKAP17A CXYorf3 DXYS155E SFRS17A XE7	Homo sapiens (Human)	695	FUNCTION: Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. {ECO:0000269|PubMed:16982639, ECO:0000269|PubMed:19840947}.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	B cell activation [GO:0042113]; mRNA processing [GO:0006397]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; signal transduction [GO:0007165]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	protein kinase A binding [GO:0051018]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; protein kinase A binding [GO:0051018]; RNA binding [GO:0003723]; B cell activation [GO:0042113]; mRNA processing [GO:0006397]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:16982639, ECO:0000269|PubMed:19840947}.
Q02078	reviewed	MEF2A_HUMAN	Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1)	MEF2A MEF2	Homo sapiens (Human)	507	FUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}.		apoptotic process [GO:0006915]; cardiac conduction [GO:0061337]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; dendrite morphogenesis [GO:0048813]; DNA-templated transcription [GO:0006351]; ERK5 cascade [GO:0070375]; heart development [GO:0007507]; MAPK cascade [GO:0000165]; mitochondrial genome maintenance [GO:0000002]; mitochondrion distribution [GO:0048311]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of transcription by RNA polymerase II [GO:0045944]; ventricular cardiac myofibril assembly [GO:0055005]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; SMAD binding [GO:0046332]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; SMAD binding [GO:0046332]; apoptotic process [GO:0006915]; cardiac conduction [GO:0061337]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; dendrite morphogenesis [GO:0048813]; DNA-templated transcription [GO:0006351]; ERK5 cascade [GO:0070375]; heart development [GO:0007507]; MAPK cascade [GO:0000165]; mitochondrial genome maintenance [GO:0000002]; mitochondrion distribution [GO:0048311]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of transcription by RNA polymerase II [GO:0045944]; ventricular cardiac myofibril assembly [GO:0055005]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:16563226}.
Q02080	reviewed	MEF2B_HUMAN	Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2)	MEF2B XMEF2	Homo sapiens (Human)	365	FUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.		cell differentiation [GO:0030154]; heart development [GO:0007507]; muscle organ development [GO:0007517]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cell junction [GO:0030054]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	cell junction [GO:0030054]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; heart development [GO:0007507]; muscle organ development [GO:0007517]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus.
Q02083	reviewed	NAAA_HUMAN	N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.60) (Acid ceramidase-like protein) (Acylsphingosine deacylase NAAA) (EC 3.5.1.23) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta]	NAAA ASAHL PLT	Homo sapiens (Human)	359	FUNCTION: Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine (PubMed:15655246, PubMed:17980170, PubMed:18793752, PubMed:30301806, PubMed:22825852). Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine (PubMed:15655246). {ECO:0000269|PubMed:15655246, ECO:0000269|PubMed:17980170, ECO:0000269|PubMed:18793752, ECO:0000269|PubMed:22825852, ECO:0000269|PubMed:30301806}.		fatty acid metabolic process [GO:0006631]; lipid catabolic process [GO:0016042]; N-acylethanolamine metabolic process [GO:0070291]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; sphingosine metabolic process [GO:0006670]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]	ceramidase activity [GO:0102121]; DNA-binding transcription factor binding [GO:0140297]; fatty acid amide hydrolase activity [GO:0017064]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]; N-(long-chain-acyl)ethanolamine deacylase activity [GO:0047412]; N-acylsphingosine amidohydrolase activity [GO:0017040]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; ceramidase activity [GO:0102121]; DNA-binding transcription factor binding [GO:0140297]; fatty acid amide hydrolase activity [GO:0017064]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]; N-(long-chain-acyl)ethanolamine deacylase activity [GO:0047412]; N-acylsphingosine amidohydrolase activity [GO:0017040]; fatty acid metabolic process [GO:0006631]; lipid catabolic process [GO:0016042]; N-acylethanolamine metabolic process [GO:0070291]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; sphingosine metabolic process [GO:0006670]	SUBCELLULAR LOCATION: Lysosome {ECO:0000305|PubMed:10610717, ECO:0000305|PubMed:15655246, ECO:0000305|PubMed:18793752}. Membrane {ECO:0000269|PubMed:30301806}; Peripheral membrane protein {ECO:0000269|PubMed:30301806}.
Q02086	reviewed	SP2_HUMAN	Transcription factor Sp2	SP2 KIAA0048	Homo sapiens (Human)	613	FUNCTION: Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.		immune response [GO:0006955]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; immune response [GO:0006955]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q02094	reviewed	RHAG_HUMAN	Ammonium transporter Rh type A (Erythrocyte membrane glycoprotein Rh50) (Erythrocyte plasma membrane 50 kDa glycoprotein) (Rh50A) (Rhesus blood group family type A glycoprotein) (Rh family type A glycoprotein) (Rh type A glycoprotein) (Rhesus blood group-associated ammonia channel) (Rhesus blood group-associated glycoprotein) (CD antigen CD241)	RHAG RH50	Homo sapiens (Human)	409	FUNCTION: Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Heterotrimer with RHCE (RHAG)2(RHCE), that transports ammonium and its related derivative methylammonium, in both neutral and ionic forms, across the erythrocyte membrane (PubMed:11861637, PubMed:11062476, PubMed:15856280, PubMed:19273840, PubMed:21849667, PubMed:22012326, PubMed:24077989, PubMed:15572441, PubMed:26354748). The transport of NH4(+) is electrogenic and masks the NH3 transport (PubMed:26354748). Also, may act as a CO2 channel (PubMed:19273840, PubMed:17712059, PubMed:24077989). In vitro, leaks monovalent cations (PubMed:18931342, PubMed:21849667). Moreover in erythrocyte, regulates RHD membrane expression (PubMed:12130520) and is associated with rhesus blood group antigen expression (PubMed:19744193, PubMed:12130520). {ECO:0000269|PubMed:11062476, ECO:0000269|PubMed:11861637, ECO:0000269|PubMed:12130520, ECO:0000269|PubMed:15572441, ECO:0000269|PubMed:15856280, ECO:0000269|PubMed:17712059, ECO:0000269|PubMed:18931342, ECO:0000269|PubMed:19273840, ECO:0000269|PubMed:19744193, ECO:0000269|PubMed:21849667, ECO:0000269|PubMed:22012326, ECO:0000269|PubMed:24077989, ECO:0000269|PubMed:26354748, ECO:0000269|PubMed:35835865}.		ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]; bicarbonate transport [GO:0015701]; carbon dioxide transmembrane transport [GO:0035378]; carbon dioxide transport [GO:0015670]; erythrocyte development [GO:0048821]; inorganic cation transmembrane transport [GO:0098662]; intracellular monoatomic ion homeostasis [GO:0006873]; methylammonium transmembrane transport [GO:0072489]; multicellular organismal-level iron ion homeostasis [GO:0060586]	ankyrin-1 complex [GO:0170014]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ammonium transmembrane transporter activity [GO:0008519]; ankyrin binding [GO:0030506]; carbon dioxide transmembrane transporter activity [GO:0035379]; leak channel activity [GO:0022840]; methylammonium transmembrane transporter activity [GO:0015200]	ankyrin-1 complex [GO:0170014]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ammonium transmembrane transporter activity [GO:0008519]; ankyrin binding [GO:0030506]; carbon dioxide transmembrane transporter activity [GO:0035379]; leak channel activity [GO:0022840]; methylammonium transmembrane transporter activity [GO:0015200]; ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]; bicarbonate transport [GO:0015701]; carbon dioxide transmembrane transport [GO:0035378]; carbon dioxide transport [GO:0015670]; erythrocyte development [GO:0048821]; inorganic cation transmembrane transport [GO:0098662]; intracellular monoatomic ion homeostasis [GO:0006873]; methylammonium transmembrane transport [GO:0072489]; multicellular organismal-level iron ion homeostasis [GO:0060586]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15856280, ECO:0000269|PubMed:18931342, ECO:0000269|PubMed:22012326, ECO:0000269|PubMed:27247322}; Multi-pass membrane protein. Note=Localization at the plasma membrane is regulated by ANK1. {ECO:0000269|PubMed:27247322}.
Q02108	reviewed	GCYA1_HUMAN	Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit)	GUCY1A1 GUC1A3 GUCSA3 GUCY1A3	Homo sapiens (Human)	690		MISCELLANEOUS: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.	blood circulation [GO:0008015]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide-cGMP-mediated signaling pathway [GO:0038060]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; regulation of blood pressure [GO:0008217]; relaxation of vascular associated smooth muscle [GO:0060087]; response to oxygen levels [GO:0070482]; retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission [GO:0098925]	cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; guanylate cyclase complex, soluble [GO:0008074]	GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; signaling receptor activity [GO:0038023]	cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; guanylate cyclase complex, soluble [GO:0008074]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; signaling receptor activity [GO:0038023]; blood circulation [GO:0008015]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide-cGMP-mediated signaling pathway [GO:0038060]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; regulation of blood pressure [GO:0008217]; relaxation of vascular associated smooth muscle [GO:0060087]; response to oxygen levels [GO:0070482]; retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission [GO:0098925]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q02127	reviewed	PYRD_HUMAN	Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase)	DHODH	Homo sapiens (Human)	395	FUNCTION: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway. {ECO:0000269|PubMed:8925840}.	MISCELLANEOUS: The identification of DHODH defects as the cause of postaxial acrofacial dysostosis (POADS) was obtained via exome sequencing (PubMed:19915526), demonstrating that this method is a powerful tool for identifying genes underlying rare Mendelian disorders. Exome sequencing consists of targeted resequencing of all protein-coding subsequences, which requires around 5% as much sequencing as a whole human genome. {ECO:0000305|PubMed:19915526}.	'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; pyrimidine ribonucleotide biosynthetic process [GO:0009220]; UDP biosynthetic process [GO:0006225]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	dihydroorotase activity [GO:0004151]; dihydroorotate dehydrogenase (quinone) activity [GO:0106430]; dihydroorotate dehydrogenase activity [GO:0004152]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; dihydroorotase activity [GO:0004151]; dihydroorotate dehydrogenase (quinone) activity [GO:0106430]; dihydroorotate dehydrogenase activity [GO:0004152]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; pyrimidine ribonucleotide biosynthetic process [GO:0009220]; UDP biosynthetic process [GO:0006225]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:10727948}; Single-pass membrane protein {ECO:0000269|PubMed:10727948}.
Q02153	reviewed	GCYB1_HUMAN	Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit)	GUCY1B1 GUC1B3 GUCSB3 GUCY1B3	Homo sapiens (Human)	619	FUNCTION: Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. {ECO:0000250|UniProtKB:P16068, ECO:0000269|PubMed:1352257}.	MISCELLANEOUS: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.	blood circulation [GO:0008015]; cellular response to nitric oxide [GO:0071732]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide-cGMP-mediated signaling pathway [GO:0038060]; response to oxygen levels [GO:0070482]; trans-synaptic signaling by nitric oxide, modulating synaptic transmission [GO:0099555]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; guanylate cyclase complex, soluble [GO:0008074]; presynaptic active zone cytoplasmic component [GO:0098831]	adenylate cyclase activity [GO:0004016]; cytidylate cyclase activity [GO:0047805]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; guanylate cyclase complex, soluble [GO:0008074]; presynaptic active zone cytoplasmic component [GO:0098831]; adenylate cyclase activity [GO:0004016]; cytidylate cyclase activity [GO:0047805]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; blood circulation [GO:0008015]; cellular response to nitric oxide [GO:0071732]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide-cGMP-mediated signaling pathway [GO:0038060]; response to oxygen levels [GO:0070482]; trans-synaptic signaling by nitric oxide, modulating synaptic transmission [GO:0099555]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P16068}.
Q02156	reviewed	KPCE_HUMAN	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon)	PRKCE PKCE	Homo sapiens (Human)	737	FUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell-substrate adhesion [GO:0031589]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; cellular response to prostaglandin E stimulus [GO:0071380]; establishment of localization in cell [GO:0051649]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; insulin secretion [GO:0030073]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; locomotory exploration behavior [GO:0035641]; macrophage activation involved in immune response [GO:0002281]; MAPK cascade [GO:0000165]; mucus secretion [GO:0070254]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of cellular glucuronidation [GO:2001031]; positive regulation of cytokinesis [GO:0032467]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of insulin secretion [GO:0032024]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mucus secretion [GO:0070257]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of wound healing [GO:0090303]; protein phosphorylation [GO:0006468]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; response to morphine [GO:0043278]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]; TRAM-dependent toll-like receptor 4 signaling pathway [GO:0035669]	cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]	14-3-3 protein binding [GO:0071889]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; calcium-independent protein kinase C activity [GO:0004699]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; ethanol binding [GO:0035276]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor activator activity [GO:0030546]	cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; 14-3-3 protein binding [GO:0071889]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; calcium-independent protein kinase C activity [GO:0004699]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; ethanol binding [GO:0035276]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor activator activity [GO:0030546]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell-substrate adhesion [GO:0031589]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; cellular response to prostaglandin E stimulus [GO:0071380]; establishment of localization in cell [GO:0051649]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; insulin secretion [GO:0030073]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; locomotory exploration behavior [GO:0035641]; macrophage activation involved in immune response [GO:0002281]; MAPK cascade [GO:0000165]; mucus secretion [GO:0070254]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of cellular glucuronidation [GO:2001031]; positive regulation of cytokinesis [GO:0032467]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of insulin secretion [GO:0032024]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mucus secretion [GO:0070257]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of wound healing [GO:0090303]; protein phosphorylation [GO:0006468]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; response to morphine [GO:0043278]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]; TRAM-dependent toll-like receptor 4 signaling pathway [GO:0035669]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:19542546}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17603037}. Cell membrane {ECO:0000269|PubMed:17603037}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P16054}. Nucleus {ECO:0000250|UniProtKB:P16054}. Note=Translocated to plasma membrane in epithelial cells stimulated by HGF (PubMed:17603037). Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). {ECO:0000250|UniProtKB:P16054, ECO:0000269|PubMed:17603037}.
Q02161	reviewed	RHD_HUMAN	Blood group Rh(D) polypeptide (RHXIII) (Rh polypeptide 2) (RhPII) (Rhesus D antigen) (CD antigen CD240D)	RHD	Homo sapiens (Human)	417	FUNCTION: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.		ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]	plasma membrane [GO:0005886]	ammonium transmembrane transporter activity [GO:0008519]	plasma membrane [GO:0005886]; ammonium transmembrane transporter activity [GO:0008519]; ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1544931, ECO:0000269|PubMed:3142870}; Multi-pass membrane protein {ECO:0000255}.
Q02218	reviewed	ODO1_HUMAN	2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)	OGDH	Homo sapiens (Human)	1023	FUNCTION: 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) (PubMed:24495017, PubMed:25210035, PubMed:28435050). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC (PubMed:24495017, PubMed:25210035, PubMed:28435050). Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (PubMed:24495017, PubMed:25210035, PubMed:28435050). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids (PubMed:25210035). Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate (PubMed:28435050). Mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). {ECO:0000269|PubMed:24495017, ECO:0000269|PubMed:25210035, ECO:0000269|PubMed:28435050, ECO:0000269|PubMed:29211711, ECO:0000303|PubMed:25210035}.	MISCELLANEOUS: [Isoform 2]: Probably insensitive to calcium. {ECO:0000305}.; MISCELLANEOUS: The mitochondrial 2-oxoglutarate and 2-oxoadipate dehydrogenase complexes (OGDHC and OADHC, respectively) share their E2 (DLST) and E3 (dihydrolipoyl dehydrogenase or DLD) components, but the E1 component is specific to each complex (E1o and E1a (DHTK1), respectively). {ECO:0000250|UniProtKB:Q96HY7}.	2-oxoglutarate metabolic process [GO:0006103]; cerebellar cortex development [GO:0021695]; generation of precursor metabolites and energy [GO:0006091]; glycolytic process [GO:0006096]; hippocampus development [GO:0021766]; histone succinylation [GO:0106077]; olfactory bulb mitral cell layer development [GO:0061034]; pyramidal neuron development [GO:0021860]; striatum development [GO:0021756]; succinyl-CoA metabolic process [GO:0006104]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; thalamus development [GO:0021794]; tricarboxylic acid cycle [GO:0006099]	mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252]	metal ion binding [GO:0046872]; oxoglutarate dehydrogenase (NAD+) activity [GO:0034602]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976]	mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252]; metal ion binding [GO:0046872]; oxoglutarate dehydrogenase (NAD+) activity [GO:0034602]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976]; 2-oxoglutarate metabolic process [GO:0006103]; cerebellar cortex development [GO:0021695]; generation of precursor metabolites and energy [GO:0006091]; glycolytic process [GO:0006096]; hippocampus development [GO:0021766]; histone succinylation [GO:0106077]; olfactory bulb mitral cell layer development [GO:0061034]; pyramidal neuron development [GO:0021860]; striatum development [GO:0021756]; succinyl-CoA metabolic process [GO:0006104]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; thalamus development [GO:0021794]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:29211711}. Nucleus {ECO:0000269|PubMed:29211711}. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation. {ECO:0000269|PubMed:29211711}.
Q02223	reviewed	TNR17_HUMAN	Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)	TNFRSF17 BCM BCMA	Homo sapiens (Human)	184	FUNCTION: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733, ECO:0000269|PubMed:10973284}.	MISCELLANEOUS: [Isoform 2]: Observed only in some CD19+ cell. {ECO:0000305}.	adaptive immune response [GO:0002250]; lymphocyte homeostasis [GO:0002260]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; adaptive immune response [GO:0002250]; lymphocyte homeostasis [GO:0002260]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.
Q02224	reviewed	CENPE_HUMAN	Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE)	CENPE	Homo sapiens (Human)	2701	FUNCTION: Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:7889940, PubMed:23891108, PubMed:25395579). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}.		attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; lateral attachment of mitotic spindle microtubules to kinetochore [GO:0099607]; metaphase chromosome alignment [GO:0051310]; microtubule plus-end directed mitotic chromosome migration [GO:0099606]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; positive regulation of protein kinase activity [GO:0045860]; regulation of mitotic metaphase/anaphase transition [GO:0030071]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle midzone [GO:1990023]; nucleus [GO:0005634]; spindle midzone [GO:0051233]	ATP binding [GO:0005524]; kinetochore binding [GO:0043515]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle midzone [GO:1990023]; nucleus [GO:0005634]; spindle midzone [GO:0051233]; ATP binding [GO:0005524]; kinetochore binding [GO:0043515]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; lateral attachment of mitotic spindle microtubules to kinetochore [GO:0099607]; metaphase chromosome alignment [GO:0051310]; microtubule plus-end directed mitotic chromosome migration [GO:0099606]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; positive regulation of protein kinase activity [GO:0045860]; regulation of mitotic metaphase/anaphase transition [GO:0030071]	SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:18374647, ECO:0000269|PubMed:18460473, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:9763420}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9763420}. Chromosome, centromere {ECO:0000269|PubMed:26321640}. Note=Associates with kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division (By similarity). Recruited to the kinetochore in a SEPT7, CENPQ and TRAPPC12-dependent manner (PubMed:18460473, PubMed:25918224, PubMed:25395579). Recruited to the pericentromeric/centromeric regions of the chromosome in a CTCF-dependent manner (PubMed:26321640). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:18460473, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:26321640}.
Q02241	reviewed	KIF23_HUMAN	Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1)	KIF23 KNSL5 MKLP1	Homo sapiens (Human)	960	FUNCTION: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}.		microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle elongation [GO:0000022]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cytokinesis [GO:0032467]	centralspindlin complex [GO:0097149]; centrosome [GO:0005813]; cytosol [GO:0005829]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	centralspindlin complex [GO:0097149]; centrosome [GO:0005813]; cytosol [GO:0005829]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle elongation [GO:0000022]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cytokinesis [GO:0032467]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.
Q02246	reviewed	CNTN2_HUMAN	Contactin-2 (Axonal glycoprotein TAG-1) (Axonin-1) (Transient axonal glycoprotein 1) (TAX-1)	CNTN2 AXT TAG1 TAX1	Homo sapiens (Human)	1040	FUNCTION: In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion. {ECO:0000269|PubMed:23518707}.		adult walking behavior [GO:0007628]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; cell adhesion [GO:0007155]; central nervous system myelination [GO:0022010]; cerebral cortex GABAergic interneuron migration [GO:0021853]; clustering of voltage-gated potassium channels [GO:0045163]; dendrite self-avoidance [GO:0070593]; establishment of localization in cell [GO:0051649]; establishment of protein localization to juxtaparanode region of axon [GO:0071206]; fat cell differentiation [GO:0045444]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; learning [GO:0007612]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of adenosine receptor signaling pathway [GO:0060168]; positive regulation of protein processing [GO:0010954]; presynaptic membrane organization [GO:0097090]; protein localization to juxtaparanode region of axon [GO:0071205]; protein processing [GO:0016485]; receptor internalization [GO:0031623]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of astrocyte differentiation [GO:0048710]; regulation of axon diameter [GO:0031133]; regulation of cell morphogenesis involved in differentiation [GO:0010769]; regulation of neuronal synaptic plasticity [GO:0048168]	axon [GO:0030424]; axon initial segment [GO:0043194]; cell surface [GO:0009986]; juxtaparanode region of axon [GO:0044224]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; side of membrane [GO:0098552]; synapse [GO:0045202]	carbohydrate binding [GO:0030246]; cell-cell adhesion mediator activity [GO:0098632]; protein self-association [GO:0043621]	axon [GO:0030424]; axon initial segment [GO:0043194]; cell surface [GO:0009986]; juxtaparanode region of axon [GO:0044224]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; side of membrane [GO:0098552]; synapse [GO:0045202]; carbohydrate binding [GO:0030246]; cell-cell adhesion mediator activity [GO:0098632]; protein self-association [GO:0043621]; adult walking behavior [GO:0007628]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; cell adhesion [GO:0007155]; central nervous system myelination [GO:0022010]; cerebral cortex GABAergic interneuron migration [GO:0021853]; clustering of voltage-gated potassium channels [GO:0045163]; dendrite self-avoidance [GO:0070593]; establishment of localization in cell [GO:0051649]; establishment of protein localization to juxtaparanode region of axon [GO:0071206]; fat cell differentiation [GO:0045444]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; learning [GO:0007612]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of adenosine receptor signaling pathway [GO:0060168]; positive regulation of protein processing [GO:0010954]; presynaptic membrane organization [GO:0097090]; protein localization to juxtaparanode region of axon [GO:0071205]; protein processing [GO:0016485]; receptor internalization [GO:0031623]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of astrocyte differentiation [GO:0048710]; regulation of axon diameter [GO:0031133]; regulation of cell morphogenesis involved in differentiation [GO:0010769]; regulation of neuronal synaptic plasticity [GO:0048168]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the neuronal membrane by a GPI-anchor and is also released from neurons.
Q02252	reviewed	MMSA_HUMAN	Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1) (Malonate-semialdehyde dehydrogenase [acylating])	ALDH6A1 MMSDH	Homo sapiens (Human)	535	FUNCTION: Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine. {ECO:0000269|PubMed:23835272}.		branched-chain amino acid catabolic process [GO:0009083]; brown fat cell differentiation [GO:0050873]; thymine catabolic process [GO:0006210]; thymine metabolic process [GO:0019859]; valine catabolic process [GO:0006574]; valine metabolic process [GO:0006573]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	malonate-semialdehyde dehydrogenase (acetylating) activity [GO:0018478]; methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity [GO:0004491]; RNA binding [GO:0003723]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; malonate-semialdehyde dehydrogenase (acetylating) activity [GO:0018478]; methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity [GO:0004491]; RNA binding [GO:0003723]; branched-chain amino acid catabolic process [GO:0009083]; brown fat cell differentiation [GO:0050873]; thymine catabolic process [GO:0006210]; thymine metabolic process [GO:0019859]; valine catabolic process [GO:0006574]; valine metabolic process [GO:0006573]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:23835272}.
Q02297	reviewed	NRG1_HUMAN	Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]	NRG1 GGF HGL HRGA NDF SMDF	Homo sapiens (Human)	640	FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}.	MISCELLANEOUS: [Isoform 10]: Potential internal signal sequence at positions 76-100. {ECO:0000305}.	activation of protein kinase B activity [GO:0032148]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; animal organ development [GO:0048513]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; cell communication [GO:0007154]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; endocardial cell differentiation [GO:0060956]; ERBB signaling pathway [GO:0038127]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERBB2-ERBB4 signaling pathway [GO:0038135]; ERBB3 signaling pathway [GO:0038129]; ERBB4 signaling pathway [GO:0038130]; ERBB4-ERBB4 signaling pathway [GO:0038138]; intracellular signal transduction [GO:0035556]; mammary gland development [GO:0030879]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of secretion [GO:0051048]; nervous system development [GO:0007399]; neural crest cell development [GO:0014032]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of striated muscle cell differentiation [GO:0051155]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; sequestering of metal ion [GO:0051238]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; ventricular cardiac muscle cell differentiation [GO:0055012]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060]	apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	chemorepellent activity [GO:0045499]; cytokine activity [GO:0005125]; ErbB-3 class receptor binding [GO:0043125]; growth factor activity [GO:0008083]; integrin binding [GO:0005178]; protein tyrosine kinase activator activity [GO:0030296]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; transcription coregulator activity [GO:0003712]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; chemorepellent activity [GO:0045499]; cytokine activity [GO:0005125]; ErbB-3 class receptor binding [GO:0043125]; growth factor activity [GO:0008083]; integrin binding [GO:0005178]; protein tyrosine kinase activator activity [GO:0030296]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; transcription coregulator activity [GO:0003712]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; activation of protein kinase B activity [GO:0032148]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; animal organ development [GO:0048513]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; cell communication [GO:0007154]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; endocardial cell differentiation [GO:0060956]; ERBB signaling pathway [GO:0038127]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERBB2-ERBB4 signaling pathway [GO:0038135]; ERBB3 signaling pathway [GO:0038129]; ERBB4 signaling pathway [GO:0038130]; ERBB4-ERBB4 signaling pathway [GO:0038138]; intracellular signal transduction [GO:0035556]; mammary gland development [GO:0030879]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of secretion [GO:0051048]; nervous system development [GO:0007399]; neural crest cell development [GO:0014032]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of striated muscle cell differentiation [GO:0051155]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; sequestering of metal ion [GO:0051238]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; ventricular cardiac muscle cell differentiation [GO:0055012]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: [Pro-neuregulin-1, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active.; SUBCELLULAR LOCATION: [Neuregulin-1]: Secreted.; SUBCELLULAR LOCATION: [Isoform 8]: Nucleus. Note=May be nuclear.; SUBCELLULAR LOCATION: [Isoform 9]: Secreted. Note=Has a signal peptide.; SUBCELLULAR LOCATION: [Isoform 10]: Membrane; Single-pass type I membrane protein. Note=May possess an internal uncleaved signal sequence.
Q02318	reviewed	CP27A_HUMAN	Sterol 26-hydroxylase, mitochondrial (EC 1.14.15.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase)	CYP27A1 CYP27	Homo sapiens (Human)	531	FUNCTION: Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid (PubMed:9660774, PubMed:12077124, PubMed:21411718, PubMed:28190002). Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways (PubMed:9660774, PubMed:1708392, PubMed:11412116, PubMed:2019602, PubMed:7915755, PubMed:9186905, PubMed:9790667). May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism (PubMed:9660774, PubMed:12077124). Plays a role in cholestanol metabolism in the cerebellum. Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation (PubMed:28190002). Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium (PubMed:21411718). May play a redundant role in vitamin D biosynthesis. Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form (PubMed:15465040). {ECO:0000269|PubMed:11412116, ECO:0000269|PubMed:12077124, ECO:0000269|PubMed:15465040, ECO:0000269|PubMed:1708392, ECO:0000269|PubMed:2019602, ECO:0000269|PubMed:21411718, ECO:0000269|PubMed:28190002, ECO:0000269|PubMed:7915755, ECO:0000269|PubMed:9186905, ECO:0000269|PubMed:9660774, ECO:0000269|PubMed:9790667}.		bile acid biosynthetic process [GO:0006699]; calcitriol biosynthetic process from calciol [GO:0036378]; cholesterol catabolic process [GO:0006707]; cholesterol metabolic process [GO:0008203]; sterol metabolic process [GO:0016125]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity [GO:0047103]; cholestanetetraol 26-dehydrogenase activity [GO:0047748]; cholestanetriol 26-monooxygenase activity [GO:0047749]; cholesterol 26-hydroxylase activity [GO:0031073]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid hydroxylase activity [GO:0008395]; vitamin D3 25-hydroxylase activity [GO:0030343]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity [GO:0047103]; cholestanetetraol 26-dehydrogenase activity [GO:0047748]; cholestanetriol 26-monooxygenase activity [GO:0047749]; cholesterol 26-hydroxylase activity [GO:0031073]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid hydroxylase activity [GO:0008395]; vitamin D3 25-hydroxylase activity [GO:0030343]; bile acid biosynthetic process [GO:0006699]; calcitriol biosynthetic process from calciol [GO:0036378]; cholesterol catabolic process [GO:0006707]; cholesterol metabolic process [GO:0008203]; sterol metabolic process [GO:0016125]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P17178}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17178}. Note=Post-translationally targeted to mitochondria. All three of the receptor proteins in the TOM complex, TOMM70, TOMM20 and TOMM22 are required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. {ECO:0000250|UniProtKB:P17178}.
Q02363	reviewed	ID2_HUMAN	DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)	ID2 BHLHB26	Homo sapiens (Human)	134	FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. {ECO:0000269|PubMed:20861012}.		bundle of His development [GO:0003166]; cell differentiation [GO:0030154]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; embryonic digestive tract morphogenesis [GO:0048557]; endodermal digestive tract morphogenesis [GO:0061031]; entrainment of circadian clock by photoperiod [GO:0043153]; enucleate erythrocyte differentiation [GO:0043353]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; heart development [GO:0007507]; locomotor rhythm [GO:0045475]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate commitment [GO:0048663]; olfactory bulb development [GO:0021772]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of blood pressure [GO:0045777]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071931]; regulation of circadian rhythm [GO:0042752]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of lipid metabolic process [GO:0019216]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of neuron differentiation [GO:0045664]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	protein dimerization activity [GO:0046983]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator inhibitor activity [GO:0140416]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein dimerization activity [GO:0046983]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator inhibitor activity [GO:0140416]; transmembrane transporter binding [GO:0044325]; bundle of His development [GO:0003166]; cell differentiation [GO:0030154]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; embryonic digestive tract morphogenesis [GO:0048557]; endodermal digestive tract morphogenesis [GO:0061031]; entrainment of circadian clock by photoperiod [GO:0043153]; enucleate erythrocyte differentiation [GO:0043353]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; heart development [GO:0007507]; locomotor rhythm [GO:0045475]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate commitment [GO:0048663]; olfactory bulb development [GO:0021772]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of blood pressure [GO:0045777]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071931]; regulation of circadian rhythm [GO:0042752]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of lipid metabolic process [GO:0019216]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of neuron differentiation [GO:0045664]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P41136}. Nucleus {ECO:0000250|UniProtKB:P41136}.
Q02383	reviewed	SEMG2_HUMAN	Semenogelin-2 (Semenogelin II) (SGII)	SEMG2	Homo sapiens (Human)	582	FUNCTION: Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.		antibacterial humoral response [GO:0019731]; coagulation [GO:0050817]; negative regulation of flagellated sperm motility [GO:1901318]; positive regulation of serine-type endopeptidase activity [GO:1900005]; sperm capacitation [GO:0048240]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]	protease binding [GO:0002020]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]; antibacterial humoral response [GO:0019731]; coagulation [GO:0050817]; negative regulation of flagellated sperm motility [GO:1901318]; positive regulation of serine-type endopeptidase activity [GO:1900005]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Secreted.
Q02388	reviewed	CO7A1_HUMAN	Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen)	COL7A1	Homo sapiens (Human)	2944	FUNCTION: Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.		cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; epidermis development [GO:0008544]; extracellular matrix organization [GO:0030198]	basement membrane [GO:0005604]; collagen type VII trimer [GO:0005590]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; serine-type endopeptidase inhibitor activity [GO:0004867]	basement membrane [GO:0005604]; collagen type VII trimer [GO:0005590]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; serine-type endopeptidase inhibitor activity [GO:0004867]; cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; epidermis development [GO:0008544]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
Q02410	reviewed	APBA1_HUMAN	Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1)	APBA1 MINT1 X11	Homo sapiens (Human)	837	FUNCTION: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}.	MISCELLANEOUS: [Isoform 2]: This isoform interacts with RAB6 GTPases. {ECO:0000305}.	axo-dendritic transport [GO:0008088]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid secretion [GO:0014051]; glutamate secretion [GO:0014047]; in utero embryonic development [GO:0001701]; intracellular protein transport [GO:0006886]; locomotory behavior [GO:0007626]; multicellular organism growth [GO:0035264]; nervous system development [GO:0007399]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein-containing complex assembly [GO:0065003]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]	amyloid-beta binding [GO:0001540]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; amyloid-beta binding [GO:0001540]; axo-dendritic transport [GO:0008088]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid secretion [GO:0014051]; glutamate secretion [GO:0014047]; in utero embryonic development [GO:0001701]; intracellular protein transport [GO:0006886]; locomotory behavior [GO:0007626]; multicellular organism growth [GO:0035264]; nervous system development [GO:0007399]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein-containing complex assembly [GO:0065003]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20531236}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20531236}. Nucleus {ECO:0000269|PubMed:20531236}. Note=Only about 5% of the protein is located in the nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus {ECO:0000269|PubMed:23737971}.
Q02413	reviewed	DSG1_HUMAN	Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen)	DSG1 CDHF4	Homo sapiens (Human)	1049	FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maternal process involved in female pregnancy [GO:0060135]; protein stabilization [GO:0050821]; response to progesterone [GO:0032570]	apical plasma membrane [GO:0016324]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; desmosome [GO:0030057]; ficolin-1-rich granule membrane [GO:0101003]; lateral plasma membrane [GO:0016328]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295]; toxic substance binding [GO:0015643]	apical plasma membrane [GO:0016324]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; desmosome [GO:0030057]; ficolin-1-rich granule membrane [GO:0101003]; lateral plasma membrane [GO:0016328]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295]; toxic substance binding [GO:0015643]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maternal process involved in female pregnancy [GO:0060135]; protein stabilization [GO:0050821]; response to progesterone [GO:0032570]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7TSF1}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q7TSF1}. Cell junction, desmosome {ECO:0000269|PubMed:34368962}. Cytoplasm {ECO:0000269|PubMed:34368962}. Nucleus {ECO:0000269|PubMed:34368962}.
Q02446	reviewed	SP4_HUMAN	Transcription factor Sp4 (SPR-1)	SP4	Homo sapiens (Human)	784	FUNCTION: Binds to GT and GC boxes promoters elements. Probable transcriptional activator.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q02447	reviewed	SP3_HUMAN	Transcription factor Sp3 (SPR-2)	SP3	Homo sapiens (Human)	781	FUNCTION: Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at Met-13 of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation at Met-286 of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative initiation at Met-303 of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing. An AUA codon is translated into Met and used as a translation initiation site (in vitro). {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative splicing. {ECO:0000305}.	B cell differentiation [GO:0030183]; definitive hemopoiesis [GO:0060216]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic placenta development [GO:0001892]; embryonic process involved in female pregnancy [GO:0060136]; embryonic skeletal system development [GO:0048706]; enucleate erythrocyte differentiation [GO:0043353]; granulocyte differentiation [GO:0030851]; liver development [GO:0001889]; lung development [GO:0030324]; megakaryocyte differentiation [GO:0030219]; monocyte differentiation [GO:0030224]; myeloid progenitor cell differentiation [GO:0002318]; natural killer cell differentiation [GO:0001779]; negative regulation of DNA-templated transcription [GO:0045892]; ossification [GO:0001503]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell differentiation [GO:0030217]; trophectodermal cell differentiation [GO:0001829]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-DNA complex [GO:0032993]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-DNA complex [GO:0032993]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; B cell differentiation [GO:0030183]; definitive hemopoiesis [GO:0060216]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic placenta development [GO:0001892]; embryonic process involved in female pregnancy [GO:0060136]; embryonic skeletal system development [GO:0048706]; enucleate erythrocyte differentiation [GO:0043353]; granulocyte differentiation [GO:0030851]; liver development [GO:0001889]; lung development [GO:0030324]; megakaryocyte differentiation [GO:0030219]; monocyte differentiation [GO:0030224]; myeloid progenitor cell differentiation [GO:0002318]; natural killer cell differentiation [GO:0001779]; negative regulation of DNA-templated transcription [GO:0045892]; ossification [GO:0001503]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell differentiation [GO:0030217]; trophectodermal cell differentiation [GO:0001829]	SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.
Q02487	reviewed	DSC2_HUMAN	Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)	DSC2 CDHF2 DSC3	Homo sapiens (Human)	901	FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.		bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cardiac muscle cell-cardiac muscle cell adhesion [GO:0086042]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cellular response to starvation [GO:0009267]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]	adherens junction [GO:0005912]; cornified envelope [GO:0001533]; cytoplasmic vesicle [GO:0031410]; desmosome [GO:0030057]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]	adherens junction [GO:0005912]; cornified envelope [GO:0001533]; cytoplasmic vesicle [GO:0031410]; desmosome [GO:0030057]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cardiac muscle cell-cardiac muscle cell adhesion [GO:0086042]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cellular response to starvation [GO:0009267]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21062920}; Single-pass type I membrane protein {ECO:0000269|PubMed:21062920}. Cell junction, desmosome {ECO:0000269|PubMed:21062920}.
Q02505	reviewed	MUC3A_HUMAN	Mucin-3A (MUC-3A) (Intestinal mucin-3A)	MUC3A MUC3	Homo sapiens (Human)	3323	FUNCTION: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. {ECO:0000269|PubMed:10405327}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886]	extracellular matrix constituent, lubricant activity [GO:0030197]; extracellular matrix structural constituent [GO:0005201]	extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886]; extracellular matrix constituent, lubricant activity [GO:0030197]; extracellular matrix structural constituent [GO:0005201]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane; Single-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000303|PubMed:10512748}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000303|PubMed:10512748}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000303|PubMed:10512748}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.
Q02535	reviewed	ID3_HUMAN	DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)	ID3 1R21 BHLHB25 HEIR1	Homo sapiens (Human)	119	FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:8437843}.		cell differentiation [GO:0030154]; cellular response to leptomycin B [GO:0072750]; central nervous system development [GO:0007417]; circadian regulation of gene expression [GO:0032922]; epithelial cell differentiation [GO:0030855]; heart development [GO:0007507]; metanephros development [GO:0001656]; muscle organ development [GO:0007517]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; notochord development [GO:0030903]; odontogenesis [GO:0042476]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; regulation of DNA replication [GO:0006275]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	bHLH transcription factor binding [GO:0043425]; leptomycin B binding [GO:1901707]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; transcription regulator inhibitor activity [GO:0140416]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; bHLH transcription factor binding [GO:0043425]; leptomycin B binding [GO:1901707]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; transcription regulator inhibitor activity [GO:0140416]; cell differentiation [GO:0030154]; cellular response to leptomycin B [GO:0072750]; central nervous system development [GO:0007417]; circadian regulation of gene expression [GO:0032922]; epithelial cell differentiation [GO:0030855]; heart development [GO:0007507]; metanephros development [GO:0001656]; muscle organ development [GO:0007517]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; notochord development [GO:0030903]; odontogenesis [GO:0042476]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; regulation of DNA replication [GO:0006275]	SUBCELLULAR LOCATION: Nucleus.
Q02539	reviewed	H11_HUMAN	Histone H1.1 (Histone H1a)	H1-1 H1F1 HIST1H1A	Homo sapiens (Human)	215	FUNCTION: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.		chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; positive regulation of receptor-mediated endocytosis [GO:0048260]; spermatogenesis [GO:0007283]	cell surface [GO:0009986]; chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; vesicle [GO:0031982]	chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; heparin binding [GO:0008201]; nucleosomal DNA binding [GO:0031492]; structural constituent of chromatin [GO:0030527]	cell surface [GO:0009986]; chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; vesicle [GO:0031982]; chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; heparin binding [GO:0008201]; nucleosomal DNA binding [GO:0031492]; structural constituent of chromatin [GO:0030527]; chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; positive regulation of receptor-mediated endocytosis [GO:0048260]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:15911621}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:15911621}. Note=Mainly localizes in euchromatin.
Q02543	reviewed	RL18A_HUMAN	Large ribosomal subunit protein eL20 (60S ribosomal protein L18a)	RPL18A	Homo sapiens (Human)	176	FUNCTION: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}.
Q02548	reviewed	PAX5_HUMAN	Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP)	PAX5	Homo sapiens (Human)	391	FUNCTION: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). {ECO:0000269|PubMed:10811620, ECO:0000269|PubMed:27181361, ECO:0000269|PubMed:32612238}.; FUNCTION: (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781). Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172). {ECO:0000269|PubMed:23678172, ECO:0000269|PubMed:31941781}.		adult behavior [GO:0030534]; anatomical structure development [GO:0048856]; B cell differentiation [GO:0030183]; cerebral cortex development [GO:0021987]; embryonic cranial skeleton morphogenesis [GO:0048701]; lateral ventricle development [GO:0021670]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; adult behavior [GO:0030534]; anatomical structure development [GO:0048856]; B cell differentiation [GO:0030183]; cerebral cortex development [GO:0021987]; embryonic cranial skeleton morphogenesis [GO:0048701]; lateral ventricle development [GO:0021670]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31941781}.
Q02556	reviewed	IRF8_HUMAN	Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP)	IRF8 ICSBP1	Homo sapiens (Human)	426	FUNCTION: Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:25122610). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed:29434592). Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). {ECO:0000250|UniProtKB:P23611, ECO:0000269|PubMed:25122610, ECO:0000269|PubMed:29434592}.		autophagy [GO:0006914]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; dendritic cell differentiation [GO:0097028]; follicular B cell differentiation [GO:0002316]; germinal center B cell differentiation [GO:0002314]; immune response [GO:0006955]; immune system process [GO:0002376]; myeloid cell differentiation [GO:0030099]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phagocytosis [GO:0006909]; plasmacytoid dendritic cell differentiation [GO:0002273]; positive regulation of apoptotic process [GO:0043065]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type I interferon production [GO:0032479]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; autophagy [GO:0006914]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; dendritic cell differentiation [GO:0097028]; follicular B cell differentiation [GO:0002316]; germinal center B cell differentiation [GO:0002314]; immune response [GO:0006955]; immune system process [GO:0002376]; myeloid cell differentiation [GO:0030099]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phagocytosis [GO:0006909]; plasmacytoid dendritic cell differentiation [GO:0002273]; positive regulation of apoptotic process [GO:0043065]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type I interferon production [GO:0032479]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:25122610}. Cytoplasm {ECO:0000269|PubMed:25122610}. Note=In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction. {ECO:0000269|PubMed:25122610}.
Q02575	reviewed	HEN1_HUMAN	Helix-loop-helix protein 1 (HEN-1) (Class A basic helix-loop-helix protein 35) (bHLHa35) (Nescient helix loop helix 1) (NSCL-1)	NHLH1 BHLHA35 HEN1	Homo sapiens (Human)	133	FUNCTION: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.		cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q02577	reviewed	HEN2_HUMAN	Helix-loop-helix protein 2 (HEN-2) (Class A basic helix-loop-helix protein 34) (bHLHa34) (Nescient helix loop helix 2) (NSCL-2)	NHLH2 BHLHA34 HEN2 KIAA0490	Homo sapiens (Human)	135	FUNCTION: Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'. Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis. Acts as a transcriptional activator of target genes, including NDN, PCSK1, MC4R (By similarity). Is also a transcriptional activator of KISS1 (PubMed:35066646). May act centrally to regulate function of both white and brown adipose tissue. Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei. Also, in concert with NHLH1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons. {ECO:0000250|UniProtKB:Q64221, ECO:0000269|PubMed:35066646}.		apoptotic process [GO:0006915]; cell migration in hindbrain [GO:0021535]; central nervous system development [GO:0007417]; hypothalamus gonadotrophin-releasing hormone neuron development [GO:0021888]; male gonad development [GO:0008584]; male mating behavior [GO:0060179]; ovulation cycle [GO:0042698]; peripheral nervous system development [GO:0007422]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; apoptotic process [GO:0006915]; cell migration in hindbrain [GO:0021535]; central nervous system development [GO:0007417]; hypothalamus gonadotrophin-releasing hormone neuron development [GO:0021888]; male gonad development [GO:0008584]; male mating behavior [GO:0060179]; ovulation cycle [GO:0042698]; peripheral nervous system development [GO:0007422]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q02641	reviewed	CACB1_HUMAN	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1)	CACNB1 CACNLB1	Homo sapiens (Human)	598	FUNCTION: Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}.		calcium ion transmembrane transport [GO:0070588]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; neuromuscular junction development [GO:0007528]; positive regulation of muscle contraction [GO:0045933]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]	L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]	high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245]	L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245]; calcium ion transmembrane transport [GO:0070588]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; neuromuscular junction development [GO:0007528]; positive regulation of muscle contraction [GO:0045933]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000305|PubMed:15615847}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19517}; Cytoplasmic side {ECO:0000250|UniProtKB:P19517}. Cell membrane {ECO:0000305|PubMed:1309651}; Peripheral membrane protein {ECO:0000305|PubMed:1309651}.
Q02643	reviewed	GHRHR_HUMAN	Growth hormone-releasing hormone receptor (GHRH receptor) (Growth hormone-releasing factor receptor) (GRF receptor) (GRFR)	GHRHR	Homo sapiens (Human)	423	FUNCTION: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP-mediated signaling [GO:0019933]; cell maturation [GO:0048469]; cell surface receptor signaling pathway [GO:0007166]; cellular response to insulin stimulus [GO:0032869]; determination of adult lifespan [GO:0008340]; establishment of localization in cell [GO:0051649]; growth hormone secretion [GO:0030252]; hormone metabolic process [GO:0042445]; lactation [GO:0007595]; multicellular organismal reproductive process [GO:0048609]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of multicellular organism growth [GO:0040018]; regulation of intracellular steroid hormone receptor signaling pathway [GO:0033143]; regulation of protein metabolic process [GO:0051246]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; somatotropin secreting cell development [GO:0060133]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]	G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; growth factor binding [GO:0019838]; growth hormone-releasing hormone receptor activity [GO:0016520]; peptide hormone binding [GO:0017046]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; growth factor binding [GO:0019838]; growth hormone-releasing hormone receptor activity [GO:0016520]; peptide hormone binding [GO:0017046]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP-mediated signaling [GO:0019933]; cell maturation [GO:0048469]; cell surface receptor signaling pathway [GO:0007166]; cellular response to insulin stimulus [GO:0032869]; determination of adult lifespan [GO:0008340]; establishment of localization in cell [GO:0051649]; growth hormone secretion [GO:0030252]; hormone metabolic process [GO:0042445]; lactation [GO:0007595]; multicellular organismal reproductive process [GO:0048609]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of multicellular organism growth [GO:0040018]; regulation of intracellular steroid hormone receptor signaling pathway [GO:0033143]; regulation of protein metabolic process [GO:0051246]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; somatotropin secreting cell development [GO:0060133]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q02742	reviewed	GCNT1_HUMAN	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GlcNAcT) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT) (Core 2 GNT) (Leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GnT-L)	GCNT1 NACGT2	Homo sapiens (Human)	428	FUNCTION: Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan (PubMed:1329093, PubMed:23027862). The catalysis is metal ion-independent and occurs with inversion of the anomeric configuration of sugar donor (By similarity). Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (By similarity). Can also act on glycolipid substrates. Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage-specific embryonic antigen 1 (SSEA-1) determinant (By similarity). Can use Galbeta1-3GalNAcalpha1- and Galbeta1-3GalNAcbeta1- oligosaccharide derivatives as acceptor substrates (By similarity). {ECO:0000250|UniProtKB:Q09324, ECO:0000269|PubMed:1329093, ECO:0000269|PubMed:23027862}.		cell adhesion molecule production [GO:0060352]; glycoprotein biosynthetic process [GO:0009101]; kidney morphogenesis [GO:0060993]; leukocyte tethering or rolling [GO:0050901]; O-glycan processing [GO:0016266]; O-glycan processing, core 2 [GO:0016268]; positive regulation of leukocyte tethering or rolling [GO:1903238]; response to insulin [GO:0032868]; tissue morphogenesis [GO:0048729]	extracellular space [GO:0005615]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]	extracellular space [GO:0005615]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; cell adhesion molecule production [GO:0060352]; glycoprotein biosynthetic process [GO:0009101]; kidney morphogenesis [GO:0060993]; leukocyte tethering or rolling [GO:0050901]; O-glycan processing [GO:0016266]; O-glycan processing, core 2 [GO:0016268]; positive regulation of leukocyte tethering or rolling [GO:1903238]; response to insulin [GO:0032868]; tissue morphogenesis [GO:0048729]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23027862}; Single-pass type II membrane protein {ECO:0000269|PubMed:23027862}. Note=Also detected in the trans-Golgi network.
Q02747	reviewed	GUC2A_HUMAN	Guanylin (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Guanylate cyclase-activating protein I) (GCAP-I) [Cleaved into: HMW-guanylin; Guanylin]	GUCA2A GUCA2	Homo sapiens (Human)	115	FUNCTION: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.			extracellular region [GO:0005576]	guanylate cyclase activator activity [GO:0030250]; hormone activity [GO:0005179]	extracellular region [GO:0005576]; guanylate cyclase activator activity [GO:0030250]; hormone activity [GO:0005179]	SUBCELLULAR LOCATION: Secreted.
Q02750	reviewed	MP2K1_HUMAN	Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)	MAP2K1 MEK1 PRKMK1	Homo sapiens (Human)	393	FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}.		Bergmann glial cell differentiation [GO:0060020]; cell motility [GO:0048870]; cellular senescence [GO:0090398]; cerebellar cortex formation [GO:0021697]; chemotaxis [GO:0006935]; endodermal cell differentiation [GO:0035987]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; keratinocyte differentiation [GO:0030216]; labyrinthine layer development [GO:0060711]; MAPK cascade [GO:0000165]; negative regulation of cell population proliferation [GO:0008285]; neuron differentiation [GO:0030182]; placenta blood vessel development [GO:0060674]; positive regulation of axonogenesis [GO:0050772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endodermal cell differentiation [GO:1903226]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; protein phosphorylation [GO:0006468]; regulation of axon regeneration [GO:0048679]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872]; signal transduction [GO:0007165]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]; type B pancreatic cell proliferation [GO:0044342]	cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; MAP-kinase scaffold activity [GO:0005078]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]	cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; MAP-kinase scaffold activity [GO:0005078]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; Bergmann glial cell differentiation [GO:0060020]; cell motility [GO:0048870]; cellular senescence [GO:0090398]; cerebellar cortex formation [GO:0021697]; chemotaxis [GO:0006935]; endodermal cell differentiation [GO:0035987]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; keratinocyte differentiation [GO:0030216]; labyrinthine layer development [GO:0060711]; MAPK cascade [GO:0000165]; negative regulation of cell population proliferation [GO:0008285]; neuron differentiation [GO:0030182]; placenta blood vessel development [GO:0060674]; positive regulation of axonogenesis [GO:0050772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endodermal cell differentiation [GO:1903226]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; protein phosphorylation [GO:0006468]; regulation of axon regeneration [GO:0048679]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872]; signal transduction [GO:0007165]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14737111}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:14737111}. Cytoplasm {ECO:0000269|PubMed:10409742, ECO:0000269|PubMed:17101779}. Nucleus {ECO:0000269|PubMed:17101779}. Membrane {ECO:0000269|PubMed:10409742}; Peripheral membrane protein {ECO:0000269|PubMed:10409742}. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (PubMed:14737111). Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742). {ECO:0000269|PubMed:10409742, ECO:0000269|PubMed:14737111}.
Q02763	reviewed	TIE2_HUMAN	Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)	TEK TIE2 VMCM VMCM1	Homo sapiens (Human)	1124	FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1. {ECO:0000269|PubMed:12816861, ECO:0000269|PubMed:14665640, ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:18366015, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:20651738, ECO:0000269|PubMed:9204896}.		angiogenesis [GO:0001525]; cell-cell signaling [GO:0007267]; definitive hemopoiesis [GO:0060216]; endochondral ossification [GO:0001958]; endothelial cell proliferation [GO:0001935]; glomerulus vasculature development [GO:0072012]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; intracellular signal transduction [GO:0035556]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of vascular permeability [GO:0043114]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; angiogenesis [GO:0001525]; cell-cell signaling [GO:0007267]; definitive hemopoiesis [GO:0060216]; endochondral ossification [GO:0001958]; endothelial cell proliferation [GO:0001935]; glomerulus vasculature development [GO:0072012]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; intracellular signal transduction [GO:0035556]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of vascular permeability [GO:0043114]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:19079259, ECO:0000269|PubMed:27270174}; Single-pass type I membrane protein. Cell junction {ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:27270174}. Cell junction, focal adhesion {ECO:0000305|PubMed:19293632}. Cytoplasm, cytoskeleton. Secreted {ECO:0000269|PubMed:11806244}. Note=Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425120, PubMed:18425119). Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:11806244). {ECO:0000269|PubMed:11806244, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120}.
Q02779	reviewed	M3K10_HUMAN	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST)	MAP3K10 MLK2 MST	Homo sapiens (Human)	954	FUNCTION: Activates the JUN N-terminal pathway. {ECO:0000250}.		apoptotic process [GO:0006915]; JNK cascade [GO:0007254]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165]; smoothened signaling pathway [GO:0007224]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; bHLH transcription factor binding [GO:0043425]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; bHLH transcription factor binding [GO:0043425]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transcription corepressor activity [GO:0003714]; apoptotic process [GO:0006915]; JNK cascade [GO:0007254]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165]; smoothened signaling pathway [GO:0007224]	
Q02790	reviewed	FKBP4_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]	FKBP4 FKBP52	Homo sapiens (Human)	459	FUNCTION: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.		androgen receptor signaling pathway [GO:0030521]; chaperone-mediated protein folding [GO:0061077]; copper ion transport [GO:0006825]; embryo implantation [GO:0007566]; male sex differentiation [GO:0046661]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of neuron projection development [GO:0010977]; prostate gland development [GO:0030850]; protein folding [GO:0006457]; protein-containing complex localization [GO:0031503]; steroid hormone receptor complex assembly [GO:0006463]	axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; copper-dependent protein binding [GO:0032767]; FK506 binding [GO:0005528]; GTP binding [GO:0005525]; heat shock protein binding [GO:0031072]; nuclear glucocorticoid receptor binding [GO:0035259]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphoprotein binding [GO:0051219]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]	axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; copper-dependent protein binding [GO:0032767]; FK506 binding [GO:0005528]; GTP binding [GO:0005525]; heat shock protein binding [GO:0031072]; nuclear glucocorticoid receptor binding [GO:0035259]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphoprotein binding [GO:0051219]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]; androgen receptor signaling pathway [GO:0030521]; chaperone-mediated protein folding [GO:0061077]; copper ion transport [GO:0006825]; embryo implantation [GO:0007566]; male sex differentiation [GO:0046661]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of neuron projection development [GO:0010977]; prostate gland development [GO:0030850]; protein folding [GO:0006457]; protein-containing complex localization [GO:0031503]; steroid hormone receptor complex assembly [GO:0006463]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:2378870}. Mitochondrion {ECO:0000269|PubMed:21730050}. Nucleus {ECO:0000250|UniProtKB:P30416}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QVC8}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QVC8}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity). {ECO:0000250|UniProtKB:Q9QVC8, ECO:0000269|PubMed:21730050}.
Q02809	reviewed	PLOD1_HUMAN	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1)	PLOD1 LLH PLOD	Homo sapiens (Human)	727	FUNCTION: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:8621606, PubMed:10686424, PubMed:15854030). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable). {ECO:0000250|UniProtKB:Q9R0E2, ECO:0000269|PubMed:10686424, ECO:0000269|PubMed:15854030, ECO:0000269|PubMed:8621606, ECO:0000305}.		epidermis development [GO:0008544]; peptidyl-lysine hydroxylation [GO:0017185]; response to hypoxia [GO:0001666]	catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; rough endoplasmic reticulum membrane [GO:0030867]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-lysine 5-dioxygenase activity [GO:0008475]	catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; rough endoplasmic reticulum membrane [GO:0030867]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-lysine 5-dioxygenase activity [GO:0008475]; epidermis development [GO:0008544]; peptidyl-lysine hydroxylation [GO:0017185]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Q02817	reviewed	MUC2_HUMAN	Mucin-2 (MUC-2) (Intestinal mucin-2)	MUC2 SMUC	Homo sapiens (Human)	5289	FUNCTION: Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (PubMed:17058067, PubMed:19432394, PubMed:33031746). Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine (PubMed:19432394, PubMed:33031746). MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange (PubMed:33031746, PubMed:36206754). Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells (PubMed:36206754). Binds both Cu(2+) and its reduced form, Cu(1+), at two juxtaposed binding sites: Cu(2+), once reduced to Cu(1+) by vitamin C (ascorbate) or other dietary antioxidants, transits to the other binding site (PubMed:36206754). MUC2-bound Cu(1+) is protected from oxidation in aerobic environments, and can be released for nutritional delivery to cells (PubMed:36206754). Mucin gels store antimicrobial molecules that participate in innate immunity (PubMed:33031746). Mucin glycoproteins also house and feed the microbiome, lubricate tissue surfaces, and may facilitate the removal of contaminants and waste products from the body (PubMed:33031746). Goblet cells synthesize two forms of MUC2 mucin that differ in branched chain O-glycosylation and the site of production in the colon: a (1) 'thick' mucus that wraps the microbiota to form fecal pellets is produced in the proximal, ascending colon (By similarity). 'Thick' mucus transits along the descending colon and is lubricated by a (2) 'thin' MUC2 mucus produced in the distal colon which adheres to the 'thick' mucus (By similarity). {ECO:0000250|UniProtKB:Q80Z19, ECO:0000269|PubMed:17058067, ECO:0000269|PubMed:19432394, ECO:0000269|PubMed:33031746, ECO:0000269|PubMed:36206754}.		detoxification of copper ion [GO:0010273]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; maintenance of gastrointestinal epithelium [GO:0030277]; mucus secretion [GO:0070254]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; inner mucus layer [GO:0070702]; outer mucus layer [GO:0070703]; plasma membrane [GO:0005886]	cupric ion binding [GO:1903135]; cuprous ion binding [GO:1903136]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; inner mucus layer [GO:0070702]; outer mucus layer [GO:0070703]; plasma membrane [GO:0005886]; cupric ion binding [GO:1903135]; cuprous ion binding [GO:1903136]; detoxification of copper ion [GO:0010273]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; maintenance of gastrointestinal epithelium [GO:0030277]; mucus secretion [GO:0070254]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:33031746}. Note=In the intestine, secreted into the inner and outer mucus layers (By similarity). Before secretion, mucin polymers are stored in dedicated secretory vesicles (PubMed:33031746). {ECO:0000250|UniProtKB:Q80Z19, ECO:0000269|PubMed:33031746}.
Q02818	reviewed	NUCB1_HUMAN	Nucleobindin-1 (CALNUC)	NUCB1 NUC	Homo sapiens (Human)	461	FUNCTION: Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}.	MISCELLANEOUS: Discovered as DNA-binding protein in the serum of lupus-prone mice.	small GTPase mediated signal transduction [GO:0007264]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q63083}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63083}; Lumenal side {ECO:0000250|UniProtKB:Q63083}. Cytoplasm {ECO:0000250|UniProtKB:Q63083}. Secreted {ECO:0000250|UniProtKB:Q63083}. Note=A small fraction of the protein may be cytoplasmic. {ECO:0000250|UniProtKB:Q63083}.
Q02833	reviewed	RASF7_HUMAN	Ras association domain-containing protein 7 (HRAS1-related cluster protein 1)	RASSF7 C11orf13 HRC1	Homo sapiens (Human)	373	FUNCTION: Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. {ECO:0000269|PubMed:20629633, ECO:0000269|PubMed:21278800}.		apoptotic process [GO:0006915]; signal transduction [GO:0007165]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]		centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; apoptotic process [GO:0006915]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20629633}. Note=Colocalizes with gamma-tubulin.
Q02846	reviewed	GUC2D_HUMAN	Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (CG-E) (Guanylate cyclase 2D, retinal) (Rod outer segment membrane guanylate cyclase) (ROS-GC)	GUCY2D CORD6 GUC1A4 GUC2D RETGC RETGC1	Homo sapiens (Human)	1103	FUNCTION: Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:21928830, PubMed:30319355, PubMed:26100624, PubMed:9600905, PubMed:15123990). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). {ECO:0000250|UniProtKB:P52785, ECO:0000269|PubMed:15123990, ECO:0000269|PubMed:21928830, ECO:0000269|PubMed:26100624, ECO:0000269|PubMed:30319355, ECO:0000269|PubMed:9600905}.	MISCELLANEOUS: The gene names for receptor guanylyl cyclases are inconsistent between mouse and human. The ortholog of the mouse Gucy2d gene is a pseudogene in humans. {ECO:0000305}.	cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; visual perception [GO:0007601]	endoplasmic reticulum membrane [GO:0005789]; nuclear outer membrane [GO:0005640]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]	endoplasmic reticulum membrane [GO:0005789]; nuclear outer membrane [GO:0005640]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000269|PubMed:7912093}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30319355}; Single-pass type I membrane protein {ECO:0000255}.
Q02878	reviewed	RL6_HUMAN	Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107)	RPL6 TXREB1	Homo sapiens (Human)	288	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:25957688, PubMed:25901680, PubMed:32669547, PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:25957688, PubMed:25901680, PubMed:32669547, PubMed:23636399). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.; FUNCTION: (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378). {ECO:0000269|PubMed:8457378}.		cytoplasmic translation [GO:0002181]; regulation of DNA-templated transcription [GO:0006355]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; postsynaptic density [GO:0014069]; rough endoplasmic reticulum [GO:0005791]	cadherin binding [GO:0045296]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; postsynaptic density [GO:0014069]; rough endoplasmic reticulum [GO:0005791]; cadherin binding [GO:0045296]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; regulation of DNA-templated transcription [GO:0006355]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q2YGT9}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q2YGT9, ECO:0000269|PubMed:25957688}.
Q02880	reviewed	TOP2B_HUMAN	DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)	TOP2B	Homo sapiens (Human)	1626	FUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}.	MISCELLANEOUS: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.	axonogenesis [GO:0007409]; B cell differentiation [GO:0030183]; cellular response to ATP [GO:0071318]; cellular response to hydrogen peroxide [GO:0070301]; cellular senescence [GO:0090398]; DNA topological change [GO:0006265]; forebrain development [GO:0030900]; neuron migration [GO:0001764]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045870]; resolution of meiotic recombination intermediates [GO:0000712]; sister chromatid segregation [GO:0000819]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]; axonogenesis [GO:0007409]; B cell differentiation [GO:0030183]; cellular response to ATP [GO:0071318]; cellular response to hydrogen peroxide [GO:0070301]; cellular senescence [GO:0090398]; DNA topological change [GO:0006265]; forebrain development [GO:0030900]; neuron migration [GO:0001764]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045870]; resolution of meiotic recombination intermediates [GO:0000712]; sister chromatid segregation [GO:0000819]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:8299728, ECO:0000269|PubMed:9155056}. Nucleus, nucleoplasm {ECO:0000269|PubMed:9155056}. Nucleus {ECO:0000269|PubMed:19690332}.
Q02928	reviewed	CP4AB_HUMAN	Cytochrome P450 4A11 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYP4AII) (CYPIVA11) (Cytochrome P-450HK-omega) (Cytochrome P450HL-omega) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)	CYP4A11 CYP4A2	Homo sapiens (Human)	519	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid (PubMed:10553002, PubMed:10660572). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:15611369). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10620324, PubMed:10660572, PubMed:15611369). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:7679927). May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PubMed:15145985). Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PubMed:18065749). Has little activity toward prostaglandins A1 and E1 (PubMed:7679927). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:10620324, ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:15611369, ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:7679927, ECO:0000269|PubMed:8914854}.		arachidonic acid metabolic process [GO:0019369]; epoxygenase P450 pathway [GO:0019373]; fatty acid metabolic process [GO:0006631]; icosanoid biosynthetic process [GO:0046456]; kidney development [GO:0001822]; lauric acid metabolic process [GO:0048252]; leukotriene metabolic process [GO:0006691]; linoleic acid metabolic process [GO:0043651]; long-chain fatty acid metabolic process [GO:0001676]; omega-hydroxylase P450 pathway [GO:0097267]; oxylipin biosynthetic process [GO:0031408]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	alkane 1-monooxygenase activity [GO:0018685]; arachidonic acid epoxygenase activity [GO:0008392]; arachidonic acid monooxygenase activity [GO:0008391]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; alkane 1-monooxygenase activity [GO:0018685]; arachidonic acid epoxygenase activity [GO:0008392]; arachidonic acid monooxygenase activity [GO:0008391]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; arachidonic acid metabolic process [GO:0019369]; epoxygenase P450 pathway [GO:0019373]; fatty acid metabolic process [GO:0006631]; icosanoid biosynthetic process [GO:0046456]; kidney development [GO:0001822]; lauric acid metabolic process [GO:0048252]; leukotriene metabolic process [GO:0006691]; linoleic acid metabolic process [GO:0043651]; long-chain fatty acid metabolic process [GO:0001676]; omega-hydroxylase P450 pathway [GO:0097267]; oxylipin biosynthetic process [GO:0031408]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:1739747}; Peripheral membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305|PubMed:1739747}; Peripheral membrane protein {ECO:0000305}.
Q02930	reviewed	CREB5_HUMAN	Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)	CREB5 CREBPA	Homo sapiens (Human)	508	FUNCTION: Binds to the cAMP response element and activates transcription. {ECO:0000269|PubMed:8378084}.		positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	cAMP response element binding [GO:0035497]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; cAMP response element binding [GO:0035497]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q02952	reviewed	AKA12_HUMAN	A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)	AKAP12 AKAP250	Homo sapiens (Human)	1782	FUNCTION: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).	MISCELLANEOUS: Antibodies against the C-terminal of gravin can be produced by patients with myasthenia gravis (MG).	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatic stellate cell activation [GO:0035733]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of vascular permeability [GO:0043116]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of hepatic stellate cell migration [GO:0061870]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of oligodendrocyte apoptotic process [GO:1900143]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of protein kinase A signaling [GO:0010738]; regulation of protein kinase C signaling [GO:0090036]; response to electrical stimulus [GO:0051602]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]	adenylate cyclase binding [GO:0008179]; calmodulin binding [GO:0005516]; protein kinase A binding [GO:0051018]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; adenylate cyclase binding [GO:0008179]; calmodulin binding [GO:0005516]; protein kinase A binding [GO:0051018]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatic stellate cell activation [GO:0035733]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of vascular permeability [GO:0043116]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of hepatic stellate cell migration [GO:0061870]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of oligodendrocyte apoptotic process [GO:1900143]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of protein kinase A signaling [GO:0010738]; regulation of protein kinase C signaling [GO:0090036]; response to electrical stimulus [GO:0051602]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=May be part of the cortical cytoskeleton.
Q02962	reviewed	PAX2_HUMAN	Paired box protein Pax-2	PAX2	Homo sapiens (Human)	417	FUNCTION: Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS. {ECO:0000269|PubMed:24676634}.		anatomical structure development [GO:0048856]; axonogenesis [GO:0007409]; brain morphogenesis [GO:0048854]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye development [GO:0043010]; cell fate determination [GO:0001709]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; glial cell differentiation [GO:0010001]; inner ear morphogenesis [GO:0042472]; mesenchymal to epithelial transition [GO:0060231]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesodermal cell fate specification [GO:0007501]; mesonephros development [GO:0001823]; metanephric collecting duct development [GO:0072205]; metanephric distal convoluted tubule development [GO:0072221]; metanephric epithelium development [GO:0072207]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchyme development [GO:0072075]; metanephric nephron tubule formation [GO:0072289]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process involved in metanephric collecting duct development [GO:1900215]; negative regulation of apoptotic process involved in metanephric nephron tubule development [GO:1900218]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis [GO:0072305]; negative regulation of mesenchymal cell apoptotic process involved in metanephros development [GO:1900212]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; nephric duct formation [GO:0072179]; neural tube closure [GO:0001843]; optic chiasma development [GO:0061360]; optic cup morphogenesis involved in camera-type eye development [GO:0002072]; optic nerve development [GO:0021554]; optic nerve morphogenesis [GO:0021631]; optic nerve structural organization [GO:0021633]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of metanephric DCT cell differentiation [GO:2000594]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of optic nerve formation [GO:2000597]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephric field specification [GO:0039003]; pronephros development [GO:0048793]; reactive oxygen species metabolic process [GO:0072593]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of metanephros size [GO:0035566]; regulation of transcription by RNA polymerase II [GO:0006357]; response to nutrient levels [GO:0031667]; retinal pigment epithelium development [GO:0003406]; stem cell differentiation [GO:0048863]; ureter development [GO:0072189]; ureter maturation [GO:0035799]; urogenital system development [GO:0001655]; vestibulocochlear nerve formation [GO:0021650]; visual perception [GO:0007601]	centriolar satellite [GO:0034451]; chromatin [GO:0000785]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription factor binding [GO:0008134]	centriolar satellite [GO:0034451]; chromatin [GO:0000785]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription factor binding [GO:0008134]; anatomical structure development [GO:0048856]; axonogenesis [GO:0007409]; brain morphogenesis [GO:0048854]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye development [GO:0043010]; cell fate determination [GO:0001709]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; glial cell differentiation [GO:0010001]; inner ear morphogenesis [GO:0042472]; mesenchymal to epithelial transition [GO:0060231]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesodermal cell fate specification [GO:0007501]; mesonephros development [GO:0001823]; metanephric collecting duct development [GO:0072205]; metanephric distal convoluted tubule development [GO:0072221]; metanephric epithelium development [GO:0072207]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchyme development [GO:0072075]; metanephric nephron tubule formation [GO:0072289]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process involved in metanephric collecting duct development [GO:1900215]; negative regulation of apoptotic process involved in metanephric nephron tubule development [GO:1900218]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis [GO:0072305]; negative regulation of mesenchymal cell apoptotic process involved in metanephros development [GO:1900212]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; nephric duct formation [GO:0072179]; neural tube closure [GO:0001843]; optic chiasma development [GO:0061360]; optic cup morphogenesis involved in camera-type eye development [GO:0002072]; optic nerve development [GO:0021554]; optic nerve morphogenesis [GO:0021631]; optic nerve structural organization [GO:0021633]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of metanephric DCT cell differentiation [GO:2000594]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of optic nerve formation [GO:2000597]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephric field specification [GO:0039003]; pronephros development [GO:0048793]; reactive oxygen species metabolic process [GO:0072593]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of metanephros size [GO:0035566]; regulation of transcription by RNA polymerase II [GO:0006357]; response to nutrient levels [GO:0031667]; retinal pigment epithelium development [GO:0003406]; stem cell differentiation [GO:0048863]; ureter development [GO:0072189]; ureter maturation [GO:0035799]; urogenital system development [GO:0001655]; vestibulocochlear nerve formation [GO:0021650]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus.
Q02978	reviewed	M2OM_HUMAN	Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11)	SLC25A11 SLC20A4	Homo sapiens (Human)	314	FUNCTION: Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity). Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity). {ECO:0000250|UniProtKB:P22292, ECO:0000250|UniProtKB:P97700, ECO:0000250|UniProtKB:Q9CR62, ECO:0000269|PubMed:21448454}.		gluconeogenesis [GO:0006094]; lipid transport [GO:0006869]; malate transmembrane transport [GO:0071423]; oxaloacetate transport [GO:0015729]; phosphate ion transmembrane transport [GO:0035435]; succinate transmembrane transport [GO:0071422]; sulfate transport [GO:0008272]; thiosulfate transport [GO:0015709]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	antiporter activity [GO:0015297]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; oxoglutarate:malate antiporter activity [GO:0015367]; RNA binding [GO:0003723]; succinate transmembrane transporter activity [GO:0015141]; sulfate transmembrane transporter activity [GO:0015116]; thiosulfate transmembrane transporter activity [GO:0015117]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; oxoglutarate:malate antiporter activity [GO:0015367]; RNA binding [GO:0003723]; succinate transmembrane transporter activity [GO:0015141]; sulfate transmembrane transporter activity [GO:0015116]; thiosulfate transmembrane transporter activity [GO:0015117]; gluconeogenesis [GO:0006094]; lipid transport [GO:0006869]; malate transmembrane transport [GO:0071423]; oxaloacetate transport [GO:0015729]; phosphate ion transmembrane transport [GO:0035435]; succinate transmembrane transport [GO:0071422]; sulfate transport [GO:0008272]; thiosulfate transport [GO:0015709]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P97700}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97700}.
Q02985	reviewed	FHR3_HUMAN	Complement factor H-related protein 3 (FHR-3) (DOWN16) (H factor-like protein 3)	CFHR3 CFHL3 FHR3	Homo sapiens (Human)	330	FUNCTION: Might be involved in complement regulation.		complement activation [GO:0006956]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	complement component C3b binding [GO:0001851]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; complement component C3b binding [GO:0001851]; complement activation [GO:0006956]	SUBCELLULAR LOCATION: Secreted.
Q03001	reviewed	DYST_HUMAN	Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)	DST BP230 BP240 BPAG1 DMH DT KIAA0728	Homo sapiens (Human)	7570	FUNCTION: Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.	MISCELLANEOUS: [Isoform 4]: Incomplete sequence. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Incomplete sequence. Transmembrane protein (helical transmembrane domain from amino acid 18 to 38). {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Incomplete sequence. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Probably myristoylated on Gly-2. Probably S-palmitoylated on Cys-5 and Cys-7. {ECO:0000305}.	cell adhesion [GO:0007155]; cell motility [GO:0048870]; cytoskeleton organization [GO:0007010]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229]; intermediate filament cytoskeleton organization [GO:0045104]; maintenance of cell polarity [GO:0030011]; microtubule cytoskeleton organization [GO:0000226]; response to wounding [GO:0009611]; retrograde axonal transport [GO:0008090]; wound healing [GO:0042060]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; H zone [GO:0031673]; hemidesmosome [GO:0030056]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Z disc [GO:0030018]	actin binding [GO:0003779]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; H zone [GO:0031673]; hemidesmosome [GO:0030056]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Z disc [GO:0030018]; actin binding [GO:0003779]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198]; cell adhesion [GO:0007155]; cell motility [GO:0048870]; cytoskeleton organization [GO:0007010]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229]; intermediate filament cytoskeleton organization [GO:0045104]; maintenance of cell polarity [GO:0030011]; microtubule cytoskeleton organization [GO:0000226]; response to wounding [GO:0009611]; retrograde axonal transport [GO:0008090]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11751855, ECO:0000269|PubMed:19932097}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q91ZU6}. Cell projection, axon {ECO:0000250|UniProtKB:Q91ZU6}. Note=Associates with intermediate filaments, actin and microtubule cytoskeletons. Localizes to actin stress fibers and to actin-rich ruffling at the cortex of cells (By similarity). Associated at the growing distal tip of microtubules. {ECO:0000250|UniProtKB:Q91ZU6}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere, H zone {ECO:0000250}. Note=Localizes to microtubules and actin microfilaments throughout the cytoplasm and at focal contact attachments at the plasma membrane. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes both cortical and cytoplasmic actin filaments. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytoskeleton. Cell junction, hemidesmosome. Note=Localizes to actin and intermediate filaments cytoskeletons (By similarity). Colocalizes with the epidermal KRT5-KRT14 intermediate filaments network of keratins. Colocalizes with ITGB4 at the leading edge of migrating keratinocytes. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 6]: Nucleus {ECO:0000250|UniProtKB:Q91ZU6}. Nucleus envelope {ECO:0000269|PubMed:10428034}. Membrane {ECO:0000269|PubMed:10428034}; Single-pass membrane protein {ECO:0000269|PubMed:10428034}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91ZU6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q91ZU6}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10428034}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q91ZU6}. Note=Localizes to actin and intermediate filaments cytoskeletons. Localizes to central actin stress fibers around the nucleus and is excluded form focal contact sites in myoblast cells. Translocates to the nucleus (By similarity). Associates with actin cytoskeleton in sensory neurons. {ECO:0000250|UniProtKB:Q91ZU6}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10428034}. Cell projection, axon {ECO:0000269|PubMed:10428034}. Membrane {ECO:0000269|PubMed:10428034}. Note=Associates with axonal microtubules and intermediate filaments, but not with actin cytoskeleton, in sensory neurons.; SUBCELLULAR LOCATION: [Isoform 8]: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Q03013	reviewed	GSTM4_HUMAN	Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4) (Leukotriene C4 synthase GSTM4) (EC 4.4.1.20)	GSTM4	Homo sapiens (Human)	218	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed:27791009). Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009). {ECO:0000269|PubMed:27791009, ECO:0000269|PubMed:8203914, ECO:0000269|PubMed:8373352}.		glutathione metabolic process [GO:0006749]; long-chain fatty acid biosynthetic process [GO:0042759]; nitrobenzene metabolic process [GO:0018916]; xenobiotic catabolic process [GO:0042178]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]	enzyme binding [GO:0019899]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; leukotriene-C4 synthase activity [GO:0004464]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; enzyme binding [GO:0019899]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; leukotriene-C4 synthase activity [GO:0004464]; protein homodimerization activity [GO:0042803]; glutathione metabolic process [GO:0006749]; long-chain fatty acid biosynthetic process [GO:0042759]; nitrobenzene metabolic process [GO:0018916]; xenobiotic catabolic process [GO:0042178]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:8373352}.
Q03014	reviewed	HHEX_HUMAN	Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH) (Proline-rich homeodomain protein)	HHEX HEX PRH PRHX	Homo sapiens (Human)	270	FUNCTION: Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636). {ECO:0000250|UniProtKB:P43120, ECO:0000269|PubMed:12554669, ECO:0000269|PubMed:20028982, ECO:0000269|PubMed:8096636}.		anterior/posterior pattern specification [GO:0009952]; B cell differentiation [GO:0030183]; cell differentiation [GO:0030154]; DNA conformation change [GO:0071103]; mRNA export from nucleus [GO:0006406]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription by transcription factor localization [GO:0010621]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; protein localization to nucleus [GO:0034504]; regulation of leukocyte proliferation [GO:0070663]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]	DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; eukaryotic initiation factor 4E binding [GO:0008190]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; TBP-class protein binding [GO:0017025]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; eukaryotic initiation factor 4E binding [GO:0008190]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; TBP-class protein binding [GO:0017025]; transcription cis-regulatory region binding [GO:0000976]; anterior/posterior pattern specification [GO:0009952]; B cell differentiation [GO:0030183]; cell differentiation [GO:0030154]; DNA conformation change [GO:0071103]; mRNA export from nucleus [GO:0006406]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription by transcription factor localization [GO:0010621]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; protein localization to nucleus [GO:0034504]; regulation of leukocyte proliferation [GO:0070663]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P43120}. Nucleus, nuclear body {ECO:0000269|PubMed:12554669}. Cytoplasm {ECO:0000269|PubMed:12554669}.
Q03052	reviewed	PO3F1_HUMAN	POU domain, class 3, transcription factor 1 (Octamer-binding protein 6) (Oct-6) (Octamer-binding transcription factor 6) (OTF-6) (POU domain transcription factor SCIP)	POU3F1 OCT6 OTF6	Homo sapiens (Human)	451	FUNCTION: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). Acts as a transcriptional repressor of myelin-specific genes (By similarity). {ECO:0000250|UniProtKB:P20267, ECO:0000250|UniProtKB:P21952}.		axon ensheathment [GO:0008366]; forebrain development [GO:0030900]; keratinocyte differentiation [GO:0030216]; myelination in peripheral nervous system [GO:0022011]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; axon ensheathment [GO:0008366]; forebrain development [GO:0030900]; keratinocyte differentiation [GO:0030216]; myelination in peripheral nervous system [GO:0022011]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P21952}.
Q03060	reviewed	CREM_HUMAN	cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER)	CREM	Homo sapiens (Human)	345	FUNCTION: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269|PubMed:10373550}.; FUNCTION: [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing of isoform 1. Activator. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 1. Activator. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative promoter usage. Activator. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative promoter usage. Repressor. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Produced by alternative splicing of isoform 6. Repressor. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Produced by alternative splicing of isoform 6. Repressor. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Produced by alternative splicing of isoform 6. Repressor. {ECO:0000305}.; MISCELLANEOUS: [Isoform 10]: Produced by alternative promoter usage. Activator. {ECO:0000305}.; MISCELLANEOUS: [Isoform 11]: Produced by alternative splicing of isoform 10. Repressor. {ECO:0000305}.; MISCELLANEOUS: [Isoform 12]: Produced by alternative splicing of isoform 5. Repressor. {ECO:0000305}.; MISCELLANEOUS: [Isoform 13]: Produced by alternative splicing of isoform 1. Activator. {ECO:0000305}.; MISCELLANEOUS: [Isoform 14]: Produced by alternative splicing of isoform 1. Activator. {ECO:0000305}.; MISCELLANEOUS: [Isoform 15]: Produced by alternative splicing of isoform 1. Repressor. {ECO:0000305}.; MISCELLANEOUS: [Isoform 16]: Produced by alternative splicing of isoform 1. Repressor. {ECO:0000305}.; MISCELLANEOUS: [Isoform 17]: Produced by alternative splicing of isoform 1. Repressor. {ECO:0000305}.; MISCELLANEOUS: [Isoform 18]: Produced by alternative splicing of isoform 1. Repressor. {ECO:0000305}.; MISCELLANEOUS: [Isoform 19]: Produced by alternative splicing of isoform 10. Activator. {ECO:0000305}.; MISCELLANEOUS: [Isoform 24]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 25]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 26]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 27]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 28]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 29]: Produced by alternative splicing. {ECO:0000305}.	cell differentiation [GO:0030154]; glycosphingolipid metabolic process [GO:0006687]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	ATF4-CREB1 transcription factor complex [GO:1990589]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	cAMP response element binding protein binding [GO:0008140]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	ATF4-CREB1 transcription factor complex [GO:1990589]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; cAMP response element binding protein binding [GO:0008140]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; glycosphingolipid metabolic process [GO:0006687]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q03111	reviewed	ENL_HUMAN	Protein ENL (YEATS domain-containing protein 1)	MLLT1 ENL LTG19 YEATS1	Homo sapiens (Human)	559	FUNCTION: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}.		positive regulation of DNA-templated transcription [GO:0045893]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]	chromatin binding [GO:0003682]; lysine-acetylated histone binding [GO:0070577]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]; chromatin binding [GO:0003682]; lysine-acetylated histone binding [GO:0070577]; positive regulation of DNA-templated transcription [GO:0045893]	SUBCELLULAR LOCATION: Nucleus.
Q03112	reviewed	MECOM_HUMAN	Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)	MECOM EVI1 MDS1 PRDM3	Homo sapiens (Human)	1230	FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. Unable to form homooligomers, to interact with CTBP1 and SMAD3 and to repress TGF-beta signaling. {ECO:0000269|PubMed:15897867, ECO:0007744|PubMed:28112733}.; MISCELLANEOUS: [Isoform 9]: Produced by alternative promoter usage. {ECO:0000305}.	apoptotic process [GO:0006915]; hematopoietic stem cell proliferation [GO:0071425]; heterochromatin organization [GO:0070828]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JNK cascade [GO:0046329]; negative regulation of programmed cell death [GO:0043069]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; apoptotic process [GO:0006915]; hematopoietic stem cell proliferation [GO:0071425]; heterochromatin organization [GO:0070828]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JNK cascade [GO:0046329]; negative regulation of programmed cell death [GO:0043069]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:9665135}. Nucleus speckle {ECO:0000269|PubMed:11568182}. Cytoplasm {ECO:0000269|PubMed:22939622}.
Q03113	reviewed	GNA12_HUMAN	Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)	GNA12	Homo sapiens (Human)	381	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986). {ECO:0000250|UniProtKB:P27600, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:12515866, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:15525651, ECO:0000269|PubMed:15980433, ECO:0000269|PubMed:16705036, ECO:0000269|PubMed:16787920, ECO:0000269|PubMed:17565996, ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:23762476, ECO:0000269|PubMed:27084452}.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; blood coagulation [GO:0007596]; cell differentiation [GO:0030154]; embryonic digit morphogenesis [GO:0042733]; G protein-coupled receptor signaling pathway [GO:0007186]; in utero embryonic development [GO:0001701]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; regulation of blood pressure [GO:0008217]; regulation of cell shape [GO:0008360]; regulation of fibroblast migration [GO:0010762]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of TOR signaling [GO:0032006]; response to xenobiotic stimulus [GO:0009410]; Rho protein signal transduction [GO:0007266]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; heterotrimeric G-protein complex [GO:0005834]; lateral plasma membrane [GO:0016328]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	D5 dopamine receptor binding [GO:0031752]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; heterotrimeric G-protein complex [GO:0005834]; lateral plasma membrane [GO:0016328]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; D5 dopamine receptor binding [GO:0031752]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; blood coagulation [GO:0007596]; cell differentiation [GO:0030154]; embryonic digit morphogenesis [GO:0042733]; G protein-coupled receptor signaling pathway [GO:0007186]; in utero embryonic development [GO:0001701]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; regulation of blood pressure [GO:0008217]; regulation of cell shape [GO:0008360]; regulation of fibroblast migration [GO:0010762]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of TOR signaling [GO:0032006]; response to xenobiotic stimulus [GO:0009410]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:15980433}; Lipid-anchor {ECO:0000250|UniProtKB:Q63210}. Lateral cell membrane {ECO:0000269|PubMed:15525651}; Lipid-anchor {ECO:0000250|UniProtKB:Q63210}. Cytoplasm {ECO:0000269|PubMed:15240885}. Note=CDH1 enhances cell membrane localization. {ECO:0000269|PubMed:15240885}.
Q03135	reviewed	CAV1_HUMAN	Caveolin-1	CAV1 CAV	Homo sapiens (Human)	178	FUNCTION: May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}.		angiogenesis [GO:0001525]; angiotensin-activated signaling pathway involved in heart process [GO:0086098]; apoptotic signaling pathway [GO:0097190]; basement membrane organization [GO:0071711]; calcium ion homeostasis [GO:0055074]; calcium ion transport [GO:0006816]; caveola assembly [GO:0070836]; caveolin-mediated endocytosis [GO:0072584]; cell differentiation [GO:0030154]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to hyperoxia [GO:0071455]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cholesterol homeostasis [GO:0042632]; cholesterol transport [GO:0030301]; cytokine-mediated signaling pathway [GO:0019221]; endothelial cell proliferation [GO:0001935]; establishment of localization in cell [GO:0051649]; fibroblast proliferation [GO:0048144]; glandular epithelial cell differentiation [GO:0002067]; insulin receptor internalization [GO:0038016]; intracellular calcium ion homeostasis [GO:0006874]; intracellular nitric oxide homeostasis [GO:0033484]; lactation [GO:0007595]; lipid storage [GO:0019915]; maintenance of protein location in cell [GO:0032507]; mammary gland development [GO:0030879]; mammary gland involution [GO:0060056]; MAPK cascade [GO:0000165]; membrane depolarization [GO:0051899]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of anoikis [GO:2000811]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of inward rectifier potassium channel activity [GO:1903609]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of necroptotic process [GO:0060546]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-tyrosine autophosphorylation [GO:1900085]; negative regulation of pinocytosis [GO:0048550]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of protein binding [GO:0032091]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of cell migration [GO:0030335]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of vasoconstriction [GO:0045907]; post-transcriptional regulation of gene expression [GO:0010608]; protein localization [GO:0008104]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to plasma membrane raft [GO:0044860]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; receptor internalization involved in canonical Wnt signaling pathway [GO:2000286]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of blood coagulation [GO:0030193]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of entry of bacterium into host cell [GO:2000535]; regulation of fatty acid metabolic process [GO:0019217]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization during action potential [GO:0098903]; regulation of peptidase activity [GO:0052547]; regulation of ruffle assembly [GO:1900027]; regulation of smooth muscle contraction [GO:0006940]; regulation of the force of heart contraction by chemical signal [GO:0003057]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; response to bacterium [GO:0009617]; response to calcium ion [GO:0051592]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; response to progesterone [GO:0032570]; skeletal muscle tissue development [GO:0007519]; T cell costimulation [GO:0031295]; triglyceride metabolic process [GO:0006641]; vasculogenesis [GO:0001570]; vasoconstriction [GO:0042310]; vesicle organization [GO:0016050]	acrosomal membrane [GO:0002080]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; caveolar macromolecular signaling complex [GO:0002095]; cell cortex [GO:0005938]; cilium [GO:0005929]; cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; membrane [GO:0016020]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATPase binding [GO:0051117]; cholesterol binding [GO:0015485]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; inward rectifier potassium channel inhibitor activity [GO:0070320]; molecular adaptor activity [GO:0060090]; nitric-oxide synthase binding [GO:0050998]; patched binding [GO:0005113]; peptidase activator activity [GO:0016504]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]	acrosomal membrane [GO:0002080]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; caveolar macromolecular signaling complex [GO:0002095]; cell cortex [GO:0005938]; cilium [GO:0005929]; cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; membrane [GO:0016020]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATPase binding [GO:0051117]; cholesterol binding [GO:0015485]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; inward rectifier potassium channel inhibitor activity [GO:0070320]; molecular adaptor activity [GO:0060090]; nitric-oxide synthase binding [GO:0050998]; patched binding [GO:0005113]; peptidase activator activity [GO:0016504]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]; angiogenesis [GO:0001525]; angiotensin-activated signaling pathway involved in heart process [GO:0086098]; apoptotic signaling pathway [GO:0097190]; basement membrane organization [GO:0071711]; calcium ion homeostasis [GO:0055074]; calcium ion transport [GO:0006816]; caveola assembly [GO:0070836]; caveolin-mediated endocytosis [GO:0072584]; cell differentiation [GO:0030154]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to hyperoxia [GO:0071455]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cholesterol homeostasis [GO:0042632]; cholesterol transport [GO:0030301]; cytokine-mediated signaling pathway [GO:0019221]; endothelial cell proliferation [GO:0001935]; establishment of localization in cell [GO:0051649]; fibroblast proliferation [GO:0048144]; glandular epithelial cell differentiation [GO:0002067]; insulin receptor internalization [GO:0038016]; intracellular calcium ion homeostasis [GO:0006874]; intracellular nitric oxide homeostasis [GO:0033484]; lactation [GO:0007595]; lipid storage [GO:0019915]; maintenance of protein location in cell [GO:0032507]; mammary gland development [GO:0030879]; mammary gland involution [GO:0060056]; MAPK cascade [GO:0000165]; membrane depolarization [GO:0051899]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of anoikis [GO:2000811]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of inward rectifier potassium channel activity [GO:1903609]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of necroptotic process [GO:0060546]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-tyrosine autophosphorylation [GO:1900085]; negative regulation of pinocytosis [GO:0048550]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of protein binding [GO:0032091]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of cell migration [GO:0030335]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of vasoconstriction [GO:0045907]; post-transcriptional regulation of gene expression [GO:0010608]; protein localization [GO:0008104]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to plasma membrane raft [GO:0044860]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; receptor internalization involved in canonical Wnt signaling pathway [GO:2000286]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of blood coagulation [GO:0030193]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of entry of bacterium into host cell [GO:2000535]; regulation of fatty acid metabolic process [GO:0019217]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization during action potential [GO:0098903]; regulation of peptidase activity [GO:0052547]; regulation of ruffle assembly [GO:1900027]; regulation of smooth muscle contraction [GO:0006940]; regulation of the force of heart contraction by chemical signal [GO:0003057]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; response to bacterium [GO:0009617]; response to calcium ion [GO:0051592]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; response to progesterone [GO:0032570]; skeletal muscle tissue development [GO:0007519]; T cell costimulation [GO:0031295]; triglyceride metabolic process [GO:0006641]; vasculogenesis [GO:0001570]; vasoconstriction [GO:0042310]; vesicle organization [GO:0016050]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola {ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25588833}; Peripheral membrane protein. Membrane raft {ECO:0000269|PubMed:25893292}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P33724}. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
Q03154	reviewed	ACY1_HUMAN	Aminoacylase-1 (ACY-1) (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase)	ACY1	Homo sapiens (Human)	408	FUNCTION: Catalyzes the hydrolysis of N-acetylated amino acids to acetate and free amino acids. {ECO:0000269|PubMed:12933810}.		amino acid metabolic process [GO:0006520]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	aminoacylase activity [GO:0004046]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; aminoacylase activity [GO:0004046]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; amino acid metabolic process [GO:0006520]	SUBCELLULAR LOCATION: Cytoplasm.
Q03164	reviewed	KMT2A_HUMAN	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1	Homo sapiens (Human)	3969	FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.		anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; cellular response to transforming growth factor beta stimulus [GO:0071560]; circadian regulation of gene expression [GO:0032922]; definitive hemopoiesis [GO:0060216]; DNA methylation [GO:0006306]; embryonic hemopoiesis [GO:0035162]; epigenetic regulation of gene expression [GO:0040029]; exploration behavior [GO:0035640]; fibroblast proliferation [GO:0048144]; homeostasis of number of cells within a tissue [GO:0048873]; membrane depolarization [GO:0051899]; negative regulation of fibroblast proliferation [GO:0048147]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; protein-containing complex assembly [GO:0065003]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to potassium ion [GO:0035864]; spleen development [GO:0048536]; T-helper 2 cell differentiation [GO:0045064]; transcription initiation-coupled chromatin remodeling [GO:0045815]; visual learning [GO:0008542]	cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; identical protein binding [GO:0042802]; lysine-acetylated histone binding [GO:0070577]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein homodimerization activity [GO:0042803]; protein-cysteine methyltransferase activity [GO:0106363]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; identical protein binding [GO:0042802]; lysine-acetylated histone binding [GO:0070577]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein homodimerization activity [GO:0042803]; protein-cysteine methyltransferase activity [GO:0106363]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]; anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; cellular response to transforming growth factor beta stimulus [GO:0071560]; circadian regulation of gene expression [GO:0032922]; definitive hemopoiesis [GO:0060216]; DNA methylation [GO:0006306]; embryonic hemopoiesis [GO:0035162]; epigenetic regulation of gene expression [GO:0040029]; exploration behavior [GO:0035640]; fibroblast proliferation [GO:0048144]; homeostasis of number of cells within a tissue [GO:0048873]; membrane depolarization [GO:0051899]; negative regulation of fibroblast proliferation [GO:0048147]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; protein-containing complex assembly [GO:0065003]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to potassium ion [GO:0035864]; spleen development [GO:0048536]; T-helper 2 cell differentiation [GO:0045064]; transcription initiation-coupled chromatin remodeling [GO:0045815]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12482972, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:34850113}.; SUBCELLULAR LOCATION: [MLL cleavage product N320]: Nucleus.; SUBCELLULAR LOCATION: [MLL cleavage product C180]: Nucleus. Note=Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320.
Q03167	reviewed	TGBR3_HUMAN	Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)	TGFBR3	Homo sapiens (Human)	851	FUNCTION: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors (By similarity). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (PubMed:34910520). {ECO:0000250|UniProtKB:P26342, ECO:0000269|PubMed:34910520}.		animal organ regeneration [GO:0031100]; BMP signaling pathway [GO:0030509]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell proliferation [GO:0060038]; cell migration [GO:0016477]; definitive erythrocyte differentiation [GO:0060318]; definitive hemopoiesis [GO:0060216]; epicardium-derived cardiac fibroblast cell development [GO:0060939]; epithelial to mesenchymal transition [GO:0001837]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; heart trabecula morphogenesis [GO:0061384]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; muscular septum morphogenesis [GO:0003150]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract morphogenesis [GO:0003151]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to follicle-stimulating hormone [GO:0032354]; response to hypoxia [GO:0001666]; response to luteinizing hormone [GO:0034699]; response to prostaglandin E [GO:0034695]; secondary palate development [GO:0062009]; transforming growth factor beta receptor complex assembly [GO:0007181]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; inhibin-betaglycan-ActRII complex [GO:0034673]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	activin binding [GO:0048185]; coreceptor activity [GO:0015026]; fibroblast growth factor binding [GO:0017134]; glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; PDZ domain binding [GO:0030165]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type III [GO:0070123]; transforming growth factor beta receptor binding [GO:0005160]; type II transforming growth factor beta receptor binding [GO:0005114]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; inhibin-betaglycan-ActRII complex [GO:0034673]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; activin binding [GO:0048185]; coreceptor activity [GO:0015026]; fibroblast growth factor binding [GO:0017134]; glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; PDZ domain binding [GO:0030165]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type III [GO:0070123]; transforming growth factor beta receptor binding [GO:0005160]; type II transforming growth factor beta receptor binding [GO:0005114]; animal organ regeneration [GO:0031100]; BMP signaling pathway [GO:0030509]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell proliferation [GO:0060038]; cell migration [GO:0016477]; definitive erythrocyte differentiation [GO:0060318]; definitive hemopoiesis [GO:0060216]; epicardium-derived cardiac fibroblast cell development [GO:0060939]; epithelial to mesenchymal transition [GO:0001837]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; heart trabecula morphogenesis [GO:0061384]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; muscular septum morphogenesis [GO:0003150]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract morphogenesis [GO:0003151]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to follicle-stimulating hormone [GO:0032354]; response to hypoxia [GO:0001666]; response to luteinizing hormone [GO:0034699]; response to prostaglandin E [GO:0034695]; secondary palate development [GO:0062009]; transforming growth factor beta receptor complex assembly [GO:0007181]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P26342}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:P26342}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P26342}. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix. {ECO:0000250|UniProtKB:P26342}.
Q03181	reviewed	PPARD_HUMAN	Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta)	PPARD NR1C2 PPARB	Homo sapiens (Human)	441	FUNCTION: Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues (PubMed:35675826). Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. {ECO:0000269|PubMed:1333051, ECO:0000269|PubMed:15604518, ECO:0000269|PubMed:35675826}.		adipose tissue development [GO:0060612]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; axon ensheathment [GO:0008366]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cell-substrate adhesion [GO:0031589]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; cholesterol metabolic process [GO:0008203]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; energy homeostasis [GO:0097009]; fat cell proliferation [GO:0070341]; fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; generation of precursor metabolites and energy [GO:0006091]; glucose metabolic process [GO:0006006]; glucose transmembrane transport [GO:1904659]; hormone-mediated signaling pathway [GO:0009755]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of inflammatory response [GO:0050728]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fat cell proliferation [GO:0070346]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of gene expression [GO:0010628]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of skeletal muscle tissue regeneration [GO:0043415]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; regulation of transcription by RNA polymerase II [GO:0006357]; wound healing [GO:0042060]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; linoleic acid binding [GO:0070539]; lipid binding [GO:0008289]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; linoleic acid binding [GO:0070539]; lipid binding [GO:0008289]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]; adipose tissue development [GO:0060612]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; axon ensheathment [GO:0008366]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cell-substrate adhesion [GO:0031589]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; cholesterol metabolic process [GO:0008203]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; energy homeostasis [GO:0097009]; fat cell proliferation [GO:0070341]; fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; generation of precursor metabolites and energy [GO:0006091]; glucose metabolic process [GO:0006006]; glucose transmembrane transport [GO:1904659]; hormone-mediated signaling pathway [GO:0009755]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of inflammatory response [GO:0050728]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fat cell proliferation [GO:0070346]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of gene expression [GO:0010628]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of skeletal muscle tissue regeneration [GO:0043415]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; regulation of transcription by RNA polymerase II [GO:0006357]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35675826}.
Q03188	reviewed	CENPC_HUMAN	Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7)	CENPC CENPC1 ICEN7	Homo sapiens (Human)	943	FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}.		attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278]; spindle attachment to meiosis I kinetochore [GO:0051455]	condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	centromeric DNA binding [GO:0019237]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]	condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; centromeric DNA binding [GO:0019237]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278]; spindle attachment to meiosis I kinetochore [GO:0051455]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17651496}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. Chromosome, centromere {ECO:0000269|PubMed:9645950}. Note=Localizes exclusively in the kinetochore domain of centromeres. {ECO:0000269|PubMed:21529714}.
Q03252	reviewed	LMNB2_HUMAN	Lamin-B2	LMNB2 LMN2	Homo sapiens (Human)	620	FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. {ECO:0000269|PubMed:33033404}.	MISCELLANEOUS: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.	heterochromatin formation [GO:0031507]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; protein localization to nuclear envelope [GO:0090435]	intermediate filament [GO:0005882]; nuclear envelope [GO:0005635]; nuclear lamina [GO:0005652]; nuclear membrane [GO:0031965]	identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200]	intermediate filament [GO:0005882]; nuclear envelope [GO:0005635]; nuclear lamina [GO:0005652]; nuclear membrane [GO:0031965]; identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200]; heterochromatin formation [GO:0031507]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; protein localization to nuclear envelope [GO:0090435]	SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000305|PubMed:33033404}.
Q03393	reviewed	PTPS_HUMAN	6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12)	PTS	Homo sapiens (Human)	145	FUNCTION: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. {ECO:0000269|PubMed:1282802}.	MISCELLANEOUS: The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit.	amino acid metabolic process [GO:0006520]; central nervous system development [GO:0007417]; tetrahydrobiopterin biosynthetic process [GO:0006729]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	6-pyruvoyltetrahydropterin synthase activity [GO:0003874]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; 6-pyruvoyltetrahydropterin synthase activity [GO:0003874]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; amino acid metabolic process [GO:0006520]; central nervous system development [GO:0007417]; tetrahydrobiopterin biosynthetic process [GO:0006729]	
Q03395	reviewed	ROM1_HUMAN	Rod outer segment membrane protein 1 (ROSP1) (Tetraspanin-23) (Tspan-23)	ROM1 TSPAN23	Homo sapiens (Human)	351	FUNCTION: Plays a role in rod outer segment (ROS) morphogenesis (By similarity). May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (By similarity). Plays a role in the organization of the ROS and maintenance of ROS disk diameter (By similarity). Involved in the maintenance of the retina outer nuclear layer (By similarity). {ECO:0000250|UniProtKB:P32958, ECO:0000250|UniProtKB:P52205}.		camera-type eye photoreceptor cell differentiation [GO:0060219]; cell adhesion [GO:0007155]; detection of light stimulus involved in visual perception [GO:0050908]; photoreceptor cell outer segment organization [GO:0035845]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; protein localization to photoreceptor outer segment [GO:1903546]; regulation of gene expression [GO:0010468]; retina vasculature development in camera-type eye [GO:0061298]; visual perception [GO:0007601]	photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]	protein homodimerization activity [GO:0042803]	photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cell adhesion [GO:0007155]; detection of light stimulus involved in visual perception [GO:0050908]; photoreceptor cell outer segment organization [GO:0035845]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; protein localization to photoreceptor outer segment [GO:1903546]; regulation of gene expression [GO:0010468]; retina vasculature development in camera-type eye [GO:0061298]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Photoreceptor inner segment membrane {ECO:0000250|UniProtKB:P32958, ECO:0000305|PubMed:1610568}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor outer segment membrane {ECO:0000269|PubMed:1610568}; Multi-pass membrane protein {ECO:0000255}.
Q03403	reviewed	TFF2_HUMAN	Trefoil factor 2 (Spasmolysin) (Spasmolytic polypeptide) (SP)	TFF2 SML1	Homo sapiens (Human)	129	FUNCTION: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity). {ECO:0000250}.		chemokine-mediated signaling pathway [GO:0070098]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of gastric acid secretion [GO:0060455]	extracellular space [GO:0005615]	CXCR4 chemokine receptor binding [GO:0031723]	extracellular space [GO:0005615]; CXCR4 chemokine receptor binding [GO:0031723]; chemokine-mediated signaling pathway [GO:0070098]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of gastric acid secretion [GO:0060455]	SUBCELLULAR LOCATION: Secreted.
Q03405	reviewed	UPAR_HUMAN	Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)	PLAUR MO3 UPAR	Homo sapiens (Human)	335	FUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.		blood coagulation [GO:0007596]; chemotaxis [GO:0006935]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of DNA binding [GO:0043388]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; regulation of cell adhesion [GO:0030155]; regulation of fibrinolysis [GO:0051917]; regulation of plasminogen activation [GO:0010755]; regulation of proteolysis [GO:0030162]; signal transduction [GO:0007165]; urokinase plasminogen activator signaling pathway [GO:0038195]	cell projection [GO:0042995]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extrinsic component of membrane [GO:0019898]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein complex involved in cell-matrix adhesion [GO:0098637]; serine-type endopeptidase complex [GO:1905370]; specific granule membrane [GO:0035579]	enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; urokinase plasminogen activator receptor activity [GO:0030377]	cell projection [GO:0042995]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extrinsic component of membrane [GO:0019898]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein complex involved in cell-matrix adhesion [GO:0098637]; serine-type endopeptidase complex [GO:1905370]; specific granule membrane [GO:0035579]; enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; urokinase plasminogen activator receptor activity [GO:0030377]; blood coagulation [GO:0007596]; chemotaxis [GO:0006935]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of DNA binding [GO:0043388]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; regulation of cell adhesion [GO:0030155]; regulation of fibrinolysis [GO:0051917]; regulation of plasminogen activation [GO:0010755]; regulation of proteolysis [GO:0030162]; signal transduction [GO:0007165]; urokinase plasminogen activator signaling pathway [GO:0038195]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12376466}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:12376466}. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000269|PubMed:12376466}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:P49616}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P49616}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000250|UniProtKB:P49616}.
Q03426	reviewed	KIME_HUMAN	Mevalonate kinase (MK) (EC 2.7.1.36)	MVK	Homo sapiens (Human)	396	FUNCTION: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:9325256, PubMed:18302342, PubMed:9392419, PubMed:11278915). {ECO:0000269|PubMed:11278915, ECO:0000269|PubMed:18302342, ECO:0000269|PubMed:9325256, ECO:0000269|PubMed:9392419}.		cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; isoprenoid biosynthetic process [GO:0008299]; negative regulation of inflammatory response [GO:0050728]; phosphorylation [GO:0016310]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisome [GO:0005777]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; mevalonate kinase activity [GO:0004496]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisome [GO:0005777]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; mevalonate kinase activity [GO:0004496]; cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; isoprenoid biosynthetic process [GO:0008299]; negative regulation of inflammatory response [GO:0050728]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14730012}. Peroxisome {ECO:0000250|UniProtKB:P17256}.
Q03431	reviewed	PTH1R_HUMAN	Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)	PTH1R PTHR PTHR1	Homo sapiens (Human)	593	FUNCTION: Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:27160269, ECO:0000269|PubMed:8397094}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone mineralization [GO:0030282]; bone resorption [GO:0045453]; cell maturation [GO:0048469]; cell population proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; chondrocyte differentiation [GO:0002062]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of cell population proliferation [GO:0008285]; osteoblast development [GO:0002076]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; skeletal system development [GO:0001501]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled peptide receptor activity [GO:0008528]; parathyroid hormone receptor activity [GO:0004991]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled peptide receptor activity [GO:0008528]; parathyroid hormone receptor activity [GO:0004991]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone mineralization [GO:0030282]; bone resorption [GO:0045453]; cell maturation [GO:0048469]; cell population proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; chondrocyte differentiation [GO:0002062]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of cell population proliferation [GO:0008285]; osteoblast development [GO:0002076]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:8397094}; Multi-pass membrane protein {ECO:0000269|PubMed:20172855}.
Q03468	reviewed	ERCC6_HUMAN	DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)	ERCC6 CSB	Homo sapiens (Human)	1493	FUNCTION: Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:20541997, PubMed:26620705, PubMed:16246722). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). It is required for transcription-coupled repair complex formation (PubMed:16916636). It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-blocking lesions (PubMed:16916636). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function. Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:16916636, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878}.		base-excision repair [GO:0006284]; chromatin remodeling [GO:0006338]; DNA damage checkpoint signaling [GO:0000077]; DNA protection [GO:0042262]; DNA repair [GO:0006281]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; JNK cascade [GO:0007254]; multicellular organism growth [GO:0035264]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; photoreceptor cell maintenance [GO:0045494]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of histone acetylation [GO:0035066]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; pyrimidine dimer repair [GO:0006290]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; response to gamma radiation [GO:0010332]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303]; response to toxic substance [GO:0009636]; response to UV-B [GO:0010224]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; transcription-coupled nucleotide-excision repair [GO:0006283]	B-WICH complex [GO:0110016]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; transcription elongation factor complex [GO:0008023]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; protein tyrosine kinase activator activity [GO:0030296]; RNA polymerase binding [GO:0070063]	B-WICH complex [GO:0110016]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; transcription elongation factor complex [GO:0008023]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; protein tyrosine kinase activator activity [GO:0030296]; RNA polymerase binding [GO:0070063]; base-excision repair [GO:0006284]; chromatin remodeling [GO:0006338]; DNA damage checkpoint signaling [GO:0000077]; DNA protection [GO:0042262]; DNA repair [GO:0006281]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; JNK cascade [GO:0007254]; multicellular organism growth [GO:0035264]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; photoreceptor cell maintenance [GO:0045494]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of histone acetylation [GO:0035066]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; pyrimidine dimer repair [GO:0006290]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; response to gamma radiation [GO:0010332]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303]; response to toxic substance [GO:0009636]; response to UV-B [GO:0010224]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; transcription-coupled nucleotide-excision repair [GO:0006283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16128801}.
Q03518	reviewed	TAP1_HUMAN	Antigen peptide transporter 1 (APT1) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 2) (Peptide supply factor 1) (Peptide transporter PSF1) (PSF-1) (Peptide transporter TAP1) (Peptide transporter involved in antigen processing 1) (Really interesting new gene 4 protein) (RING4)	TAP1 ABCB2 PSF1 RING4 Y3	Homo sapiens (Human)	748	FUNCTION: ABC transporter associated with antigen processing. In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules (PubMed:25656091, PubMed:25377891). Uses the chemical energy of ATP to export peptides against the concentration gradient (PubMed:25377891). During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle (PubMed:25377891, PubMed:25656091, PubMed:11274390). Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome. Binds peptides with free N- and C-termini, the first three and the C-terminal residues being critical. Preferentially selects peptides having a highly hydrophobic residue at position 3 and hydrophobic or charged residues at the C-terminal anchor. Proline at position 2 has the most destabilizing effect (PubMed:7500034, PubMed:9256420, PubMed:11274390). As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation (PubMed:26611325, PubMed:1538751, PubMed:25377891). {ECO:0000269|PubMed:11274390, ECO:0000269|PubMed:1538751, ECO:0000269|PubMed:25377891, ECO:0000269|PubMed:25656091, ECO:0000269|PubMed:26611325, ECO:0000269|PubMed:7500034, ECO:0000269|PubMed:9256420}.		adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; cytosol to endoplasmic reticulum transport [GO:0046967]; defense response [GO:0006952]; peptide transport [GO:0015833]; protein transport [GO:0015031]; transmembrane transport [GO:0055085]	centriolar satellite [GO:0034451]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; phagocytic vesicle membrane [GO:0030670]; TAP complex [GO:0042825]	ABC-type peptide antigen transporter activity [GO:0015433]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; MHC class I protein binding [GO:0042288]; MHC class Ib protein binding [GO:0023029]; peptide antigen binding [GO:0042605]; peptide transmembrane transporter activity [GO:1904680]; protein homodimerization activity [GO:0042803]; TAP1 binding [GO:0046978]; TAP2 binding [GO:0046979]	centriolar satellite [GO:0034451]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; phagocytic vesicle membrane [GO:0030670]; TAP complex [GO:0042825]; ABC-type peptide antigen transporter activity [GO:0015433]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; MHC class I protein binding [GO:0042288]; MHC class Ib protein binding [GO:0023029]; peptide antigen binding [GO:0042605]; peptide transmembrane transporter activity [GO:1904680]; protein homodimerization activity [GO:0042803]; TAP1 binding [GO:0046978]; TAP2 binding [GO:0046979]; adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; cytosol to endoplasmic reticulum transport [GO:0046967]; defense response [GO:0006952]; peptide transport [GO:0015833]; protein transport [GO:0015031]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:1589036, ECO:0000269|PubMed:22638925}; Multi-pass membrane protein {ECO:0000255}. Note=The transmembrane segments seem to form a pore in the membrane.
Q03519	reviewed	TAP2_HUMAN	Antigen peptide transporter 2 (APT2) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 3) (Peptide supply factor 2) (Peptide transporter PSF2) (PSF-2) (Peptide transporter TAP2) (Peptide transporter involved in antigen processing 2) (Really interesting new gene 11 protein) (RING11)	TAP2 ABCB3 PSF2 RING11 Y1	Homo sapiens (Human)	686	FUNCTION: ABC transporter associated with antigen processing. In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules (PubMed:25656091, PubMed:25377891). Uses the chemical energy of ATP to export peptides against the concentration gradient (PubMed:25377891). During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle (PubMed:25377891, PubMed:25656091, PubMed:11274390). Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome. Binds peptides with free N- and C-termini, the first three and the C-terminal residues being critical. Preferentially selects peptides having a highly hydrophobic residue at position 3 and hydrophobic or charged residues at the C-terminal anchor. Proline at position 2 has the most destabilizing effect (PubMed:7500034, PubMed:9256420, PubMed:11274390). As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation (PubMed:26611325, PubMed:1538751, PubMed:25377891). {ECO:0000269|PubMed:11274390, ECO:0000269|PubMed:1538751, ECO:0000269|PubMed:25377891, ECO:0000269|PubMed:25656091, ECO:0000269|PubMed:26611325, ECO:0000269|PubMed:7500034, ECO:0000269|PubMed:9256420}.		antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; cytosol to endoplasmic reticulum transport [GO:0046967]; peptide antigen transport [GO:0046968]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein transport [GO:0015031]; response to molecule of bacterial origin [GO:0002237]; T cell mediated cytotoxicity [GO:0001913]; transmembrane transport [GO:0055085]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; nuclear speck [GO:0016607]; phagocytic vesicle membrane [GO:0030670]; TAP complex [GO:0042825]	ABC-type peptide antigen transporter activity [GO:0015433]; ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; MHC class Ib protein binding [GO:0023029]; peptide antigen binding [GO:0042605]; TAP1 binding [GO:0046978]; tapasin binding [GO:0046980]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; nuclear speck [GO:0016607]; phagocytic vesicle membrane [GO:0030670]; TAP complex [GO:0042825]; ABC-type peptide antigen transporter activity [GO:0015433]; ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; MHC class Ib protein binding [GO:0023029]; peptide antigen binding [GO:0042605]; TAP1 binding [GO:0046978]; tapasin binding [GO:0046980]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; cytosol to endoplasmic reticulum transport [GO:0046967]; peptide antigen transport [GO:0046968]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein transport [GO:0015031]; response to molecule of bacterial origin [GO:0002237]; T cell mediated cytotoxicity [GO:0001913]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:1589036, ECO:0000269|PubMed:22638925}; Multi-pass membrane protein {ECO:0000255}. Note=The transmembrane segments seem to form a pore in the membrane.
Q03591	reviewed	FHR1_HUMAN	Complement factor H-related protein 1 (FHR-1) (H factor-like protein 1) (FHL-1) (H-factor-like 1) (H36)	CFHR1 CFHL CFHL1 CFHL1P CFHR1P FHR1 HFL1 HFL2	Homo sapiens (Human)	330	FUNCTION: Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. {ECO:0000269|PubMed:23487775}.		complement activation [GO:0006956]; cytolysis by host of symbiont cells [GO:0051838]; negative regulation of protein binding [GO:0032091]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]	complement component C3b binding [GO:0001851]; identical protein binding [GO:0042802]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]; complement component C3b binding [GO:0001851]; identical protein binding [GO:0042802]; complement activation [GO:0006956]; cytolysis by host of symbiont cells [GO:0051838]; negative regulation of protein binding [GO:0032091]	SUBCELLULAR LOCATION: Secreted.
Q03692	reviewed	COAA1_HUMAN	Collagen alpha-1(X) chain	COL10A1	Homo sapiens (Human)	680	FUNCTION: Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.		extracellular matrix organization [GO:0030198]; skeletal system development [GO:0001501]	collagen trimer [GO:0005581]; collagen type X trimer [GO:0005599]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]	collagen trimer [GO:0005581]; collagen type X trimer [GO:0005599]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]; extracellular matrix organization [GO:0030198]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q03721	reviewed	KCNC4_HUMAN	Potassium voltage-gated channel subfamily C member 4 (KSHIIIC) (Voltage-gated potassium channel subunit Kv3.4)	KCNC4 C1orf30	Homo sapiens (Human)	635	FUNCTION: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.	MISCELLANEOUS: [Isoform 2]: Could be a cloning artifact. {ECO:0000305}.	chemical synaptic transmission [GO:0007268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; potassium channel activity [GO:0005267]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; potassium channel activity [GO:0005267]; voltage-gated potassium channel activity [GO:0005249]; chemical synaptic transmission [GO:0007268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q03923	reviewed	ZNF85_HUMAN	Zinc finger protein 85 (Zinc finger protein HPF4) (Zinc finger protein HTF1)	ZNF85	Homo sapiens (Human)	595	FUNCTION: May be a transcriptional repressor. {ECO:0000269|PubMed:9839802}.		regulation of DNA-templated transcription [GO:0006355]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9839802}.
Q03933	reviewed	HSF2_HUMAN	Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2)	HSF2 HSTF2	Homo sapiens (Human)	536	FUNCTION: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8339932}. Nucleus {ECO:0000269|PubMed:8339932}. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.
Q03989	reviewed	ARI5A_HUMAN	AT-rich interactive domain-containing protein 5A (ARID domain-containing protein 5A) (Modulator recognition factor 1) (MRF-1)	ARID5A MRF1	Homo sapiens (Human)	594	FUNCTION: Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity). {ECO:0000250|UniProtKB:Q3U108, ECO:0000269|PubMed:15941852, ECO:0000269|PubMed:8649988}.		cellular response to estrogen stimulus [GO:0071391]; cellular response to lipopolysaccharide [GO:0071222]; chondrocyte differentiation [GO:0002062]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of protein acetylation [GO:1901985]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA stem-loop binding [GO:0035613]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA stem-loop binding [GO:0035613]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; cellular response to estrogen stimulus [GO:0071391]; cellular response to lipopolysaccharide [GO:0071222]; chondrocyte differentiation [GO:0002062]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of protein acetylation [GO:1901985]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:8649988}.
Q04118	reviewed	PRB3_HUMAN	Basic salivary proline-rich protein 3 (Parotid salivary glycoprotein G1) (Proline-rich protein G1)	PRB3	Homo sapiens (Human)	309	FUNCTION: Acts as a receptor for the Gram-negative bacterium F.nucleatum. {ECO:0000269|PubMed:1894623}.		defense response to Gram-negative bacterium [GO:0050829]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to Gram-negative bacterium [GO:0050829]	SUBCELLULAR LOCATION: Secreted.
Q04206	reviewed	TF65_HUMAN	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)	RELA NFKB3	Homo sapiens (Human)	551	FUNCTION: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}.		acetaldehyde metabolic process [GO:0006117]; animal organ morphogenesis [GO:0009887]; canonical NF-kappaB signal transduction [GO:0007249]; cellular defense response [GO:0006968]; cellular response to angiotensin [GO:1904385]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to nicotine [GO:0071316]; cellular response to peptidoglycan [GO:0071224]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chromatin organization [GO:0006325]; cytokine-mediated signaling pathway [GO:0019221]; defense response to tumor cell [GO:0002357]; defense response to virus [GO:0051607]; DNA-templated transcription [GO:0006351]; hair follicle development [GO:0001942]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuropeptide signaling pathway [GO:0007218]; non-canonical NF-kappaB signal transduction [GO:0038061]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of Schwann cell differentiation [GO:0014040]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of vascular endothelial growth factor production [GO:0010575]; postsynapse to nucleus signaling pathway [GO:0099527]; protein catabolic process [GO:0030163]; regulation of DNA-templated transcription [GO:0006355]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of inflammatory response [GO:0050727]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of transcription by RNA polymerase II [GO:0006357]; response to amino acid [GO:0043200]; response to cAMP [GO:0051591]; response to cobalamin [GO:0033590]; response to cytokine [GO:0034097]; response to insulin [GO:0032868]; response to interleukin-1 [GO:0070555]; response to ischemia [GO:0002931]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; response to organic substance [GO:0010033]; response to progesterone [GO:0032570]; response to UV-B [GO:0010224]; response to xenobiotic stimulus [GO:0009410]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; NF-kappaB complex [GO:0071159]; NF-kappaB p50/p65 complex [GO:0035525]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	actinin binding [GO:0042805]; ankyrin repeat binding [GO:0071532]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; general transcription initiation factor binding [GO:0140296]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; peptide binding [GO:0042277]; phosphate ion binding [GO:0042301]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; NF-kappaB complex [GO:0071159]; NF-kappaB p50/p65 complex [GO:0035525]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; actinin binding [GO:0042805]; ankyrin repeat binding [GO:0071532]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; general transcription initiation factor binding [GO:0140296]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; peptide binding [GO:0042277]; phosphate ion binding [GO:0042301]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; ubiquitin protein ligase binding [GO:0031625]; acetaldehyde metabolic process [GO:0006117]; animal organ morphogenesis [GO:0009887]; canonical NF-kappaB signal transduction [GO:0007249]; cellular defense response [GO:0006968]; cellular response to angiotensin [GO:1904385]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to nicotine [GO:0071316]; cellular response to peptidoglycan [GO:0071224]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chromatin organization [GO:0006325]; cytokine-mediated signaling pathway [GO:0019221]; defense response to tumor cell [GO:0002357]; defense response to virus [GO:0051607]; DNA-templated transcription [GO:0006351]; hair follicle development [GO:0001942]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuropeptide signaling pathway [GO:0007218]; non-canonical NF-kappaB signal transduction [GO:0038061]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of Schwann cell differentiation [GO:0014040]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of vascular endothelial growth factor production [GO:0010575]; postsynapse to nucleus signaling pathway [GO:0099527]; protein catabolic process [GO:0030163]; regulation of DNA-templated transcription [GO:0006355]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of inflammatory response [GO:0050727]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of transcription by RNA polymerase II [GO:0006357]; response to amino acid [GO:0043200]; response to cAMP [GO:0051591]; response to cobalamin [GO:0033590]; response to cytokine [GO:0034097]; response to insulin [GO:0032868]; response to interleukin-1 [GO:0070555]; response to ischemia [GO:0002931]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; response to organic substance [GO:0010033]; response to progesterone [GO:0032570]; response to UV-B [GO:0010224]; response to xenobiotic stimulus [GO:0009410]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1493333, ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:25355951}. Cytoplasm {ECO:0000269|PubMed:1493333, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:24807716, ECO:0000269|PubMed:27736973}. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B) (PubMed:1493333). Colocalized with DDX1 in the nucleus upon TNF-alpha induction (PubMed:19058135). Colocalizes with GFI1 in the nucleus after LPS stimulation (PubMed:20547752). Translocation to the nucleus is impaired in L.monocytogenes infection (PubMed:20855622). {ECO:0000269|PubMed:1493333, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:20855622}.
Q04323	reviewed	UBXN1_HUMAN	UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein)	UBXN1 SAKS1	Homo sapiens (Human)	297	FUNCTION: Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497). Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446). Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (PubMed:20351172). Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. {ECO:0000269|PubMed:20351172, ECO:0000269|PubMed:23545497, ECO:0000269|PubMed:25681446, ECO:0000269|PubMed:28152074}.		negative regulation of ERAD pathway [GO:1904293]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein K48-linked deubiquitination [GO:1903094]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of ubiquitin-specific protease activity [GO:2000157]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	ATPase binding [GO:0051117]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K6-linked polyubiquitin modification-dependent protein binding [GO:0071796]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome regulatory particle binding [GO:1904855]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; ATPase binding [GO:0051117]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K6-linked polyubiquitin modification-dependent protein binding [GO:0071796]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome regulatory particle binding [GO:1904855]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; negative regulation of ERAD pathway [GO:1904293]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein K48-linked deubiquitination [GO:1903094]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of ubiquitin-specific protease activity [GO:2000157]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23545497}.
Q04446	reviewed	GLGB_HUMAN	1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme)	GBE1	Homo sapiens (Human)	702	FUNCTION: Required for normal glycogen accumulation (PubMed:8463281, PubMed:26199317, PubMed:8613547). The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable). {ECO:0000269|PubMed:26199317, ECO:0000269|PubMed:8463281, ECO:0000269|PubMed:8613547, ECO:0000305}.		generation of precursor metabolites and energy [GO:0006091]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; negative regulation of neuron apoptotic process [GO:0043524]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	1,4-alpha-glucan branching enzyme activity [GO:0003844]; 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) [GO:0102752]; carbohydrate binding [GO:0030246]; cation binding [GO:0043169]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 1,4-alpha-glucan branching enzyme activity [GO:0003844]; 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) [GO:0102752]; carbohydrate binding [GO:0030246]; cation binding [GO:0043169]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; generation of precursor metabolites and energy [GO:0006091]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; negative regulation of neuron apoptotic process [GO:0043524]	
Q04609	reviewed	FOLH1_HUMAN	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Cell growth-inhibiting gene 27 protein) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen) (PSM) (PSMA) (Pteroylpoly-gamma-glutamate carboxypeptidase)	FOLH1 FOLH NAALAD1 PSM PSMA GIG27	Homo sapiens (Human)	750	FUNCTION: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.; FUNCTION: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.	MISCELLANEOUS: PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimer disease and Huntington disease.	C-terminal protein deglutamylation [GO:0035609]; folic acid-containing compound metabolic process [GO:0006760]; proteolysis [GO:0006508]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	Ac-Asp-Glu binding [GO:1904492]; carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallocarboxypeptidase activity [GO:0004181]; peptidase activity [GO:0008233]; tetrahydrofolyl-poly(glutamate) polymer binding [GO:1904493]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; Ac-Asp-Glu binding [GO:1904492]; carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallocarboxypeptidase activity [GO:0004181]; peptidase activity [GO:0008233]; tetrahydrofolyl-poly(glutamate) polymer binding [GO:1904493]; C-terminal protein deglutamylation [GO:0035609]; folic acid-containing compound metabolic process [GO:0006760]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9809977}; Single-pass type II membrane protein {ECO:0000269|PubMed:9809977}.; SUBCELLULAR LOCATION: [Isoform PSMA']: Cytoplasm {ECO:0000269|PubMed:9809977}.
Q04637	reviewed	IF4G1_HUMAN	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220)	EIF4G1 EIF4F EIF4G EIF4GI	Homo sapiens (Human)	1599	FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}.	MISCELLANEOUS: [Isoform B]: Produced by alternative initiation at Met-41 of isoform A. {ECO:0000305}.; MISCELLANEOUS: [Isoform C]: Produced by alternative initiation at Met-88 of isoform A. {ECO:0000305}.; MISCELLANEOUS: [Isoform D]: Produced by alternative initiation at Met-165 of isoform A. {ECO:0000305}.; MISCELLANEOUS: [Isoform E]: Produced by alternative initiation at Met-197 of isoform A. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Produced by alternative splicing. {ECO:0000305}.	behavioral fear response [GO:0001662]; cap-dependent translational initiation [GO:0002191]; cellular response to nutrient levels [GO:0031669]; energy homeostasis [GO:0097009]; lung development [GO:0030324]; macromolecule biosynthetic process [GO:0009059]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of autophagy [GO:0010507]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; neuron differentiation [GO:0030182]; positive regulation of cell growth [GO:0030307]; positive regulation of eukaryotic translation initiation factor 4F complex assembly [GO:1905537]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of mRNA cap binding [GO:1905612]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of cellular response to stress [GO:0080135]; regulation of polysome binding [GO:1905696]; regulation of presynapse assembly [GO:1905606]; regulation of translational initiation [GO:0006446]; response to ethanol [GO:0045471]; translation [GO:0006412]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; nucleus [GO:0005634]; polysome [GO:0005844]; postsynapse [GO:0098794]	ATP binding [GO:0005524]; eukaryotic initiation factor 4E binding [GO:0008190]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; nucleus [GO:0005634]; polysome [GO:0005844]; postsynapse [GO:0098794]; ATP binding [GO:0005524]; eukaryotic initiation factor 4E binding [GO:0008190]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]; behavioral fear response [GO:0001662]; cap-dependent translational initiation [GO:0002191]; cellular response to nutrient levels [GO:0031669]; energy homeostasis [GO:0097009]; lung development [GO:0030324]; macromolecule biosynthetic process [GO:0009059]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of autophagy [GO:0010507]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; neuron differentiation [GO:0030182]; positive regulation of cell growth [GO:0030307]; positive regulation of eukaryotic translation initiation factor 4F complex assembly [GO:1905537]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of mRNA cap binding [GO:1905612]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of cellular response to stress [GO:0080135]; regulation of polysome binding [GO:1905696]; regulation of presynapse assembly [GO:1905606]; regulation of translational initiation [GO:0006446]; response to ethanol [GO:0045471]; translation [GO:0006412]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17984221}. Nucleus {ECO:0000269|PubMed:17984221}. Cytoplasm, Stress granule {ECO:0000269|PubMed:22872150}.
Q04656	reviewed	ATP7A_HUMAN	Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein)	ATP7A MC1 MNK	Homo sapiens (Human)	1500	FUNCTION: ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:31283225, PubMed:28389643). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:28389643, PubMed:11092760). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (PubMed:28389643) (By similarity). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}.	MISCELLANEOUS: [Isoform 3]: Lacks 6 transmembrane regions and 5 heavy-metal-associated (HMA) domains. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Lacks the transmembrane domains 3 and 4. Expressed at a low level in several tissues of normal individuals and is the only isoform found in patients with OHS. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Lacks all transmembrane regions and 5 heavy-metal-associated (HMA) domains, but has a putative nuclear localization signal attached at the N-terminus. {ECO:0000305}.	blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cartilage development [GO:0051216]; catecholamine metabolic process [GO:0006584]; cellular response to amino acid stimulus [GO:0071230]; cellular response to antibiotic [GO:0071236]; cellular response to cadmium ion [GO:0071276]; cellular response to cobalt ion [GO:0071279]; cellular response to copper ion [GO:0071280]; cellular response to hypoxia [GO:0071456]; cellular response to iron ion [GO:0071281]; cellular response to lead ion [GO:0071284]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; central nervous system neuron development [GO:0021954]; cerebellar Purkinje cell differentiation [GO:0021702]; collagen fibril organization [GO:0030199]; copper ion export [GO:0060003]; copper ion homeostasis [GO:0055070]; copper ion import [GO:0015677]; copper ion transport [GO:0006825]; detoxification of copper ion [GO:0010273]; dopamine metabolic process [GO:0042417]; elastic fiber assembly [GO:0048251]; elastin biosynthetic process [GO:0051542]; epinephrine metabolic process [GO:0042414]; extracellular matrix organization [GO:0030198]; female pregnancy [GO:0007565]; hair follicle morphogenesis [GO:0031069]; in utero embryonic development [GO:0001701]; intracellular copper ion homeostasis [GO:0006878]; lactation [GO:0007595]; liver development [GO:0001889]; locomotory behavior [GO:0007626]; lung alveolus development [GO:0048286]; mitochondrion organization [GO:0007005]; negative regulation of iron ion transmembrane transport [GO:0034760]; neuron projection morphogenesis [GO:0048812]; norepinephrine metabolic process [GO:0042415]; peptidyl-lysine modification [GO:0018205]; pigmentation [GO:0043473]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell size [GO:0045793]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of response to wounding [GO:1903036]; positive regulation of tyrosinase activity [GO:0032773]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; pyramidal neuron development [GO:0021860]; regulation of oxidative phosphorylation [GO:0002082]; removal of superoxide radicals [GO:0019430]; response to iron(III) ion [GO:0010041]; response to manganese ion [GO:0010042]; response to zinc ion [GO:0010043]; serotonin metabolic process [GO:0042428]; skin development [GO:0043588]; T-helper cell differentiation [GO:0042093]; tryptophan metabolic process [GO:0006568]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; microvillus [GO:0005902]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; secretory granule [GO:0030141]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; copper-dependent protein binding [GO:0032767]; cuprous ion binding [GO:1903136]; P-type divalent copper transporter activity [GO:0043682]; P-type monovalent copper transporter activity [GO:0140581]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; superoxide dismutase copper chaperone activity [GO:0016532]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; microvillus [GO:0005902]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; secretory granule [GO:0030141]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; copper-dependent protein binding [GO:0032767]; cuprous ion binding [GO:1903136]; P-type divalent copper transporter activity [GO:0043682]; P-type monovalent copper transporter activity [GO:0140581]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; superoxide dismutase copper chaperone activity [GO:0016532]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cartilage development [GO:0051216]; catecholamine metabolic process [GO:0006584]; cellular response to amino acid stimulus [GO:0071230]; cellular response to antibiotic [GO:0071236]; cellular response to cadmium ion [GO:0071276]; cellular response to cobalt ion [GO:0071279]; cellular response to copper ion [GO:0071280]; cellular response to hypoxia [GO:0071456]; cellular response to iron ion [GO:0071281]; cellular response to lead ion [GO:0071284]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; central nervous system neuron development [GO:0021954]; cerebellar Purkinje cell differentiation [GO:0021702]; collagen fibril organization [GO:0030199]; copper ion export [GO:0060003]; copper ion homeostasis [GO:0055070]; copper ion import [GO:0015677]; copper ion transport [GO:0006825]; detoxification of copper ion [GO:0010273]; dopamine metabolic process [GO:0042417]; elastic fiber assembly [GO:0048251]; elastin biosynthetic process [GO:0051542]; epinephrine metabolic process [GO:0042414]; extracellular matrix organization [GO:0030198]; female pregnancy [GO:0007565]; hair follicle morphogenesis [GO:0031069]; in utero embryonic development [GO:0001701]; intracellular copper ion homeostasis [GO:0006878]; lactation [GO:0007595]; liver development [GO:0001889]; locomotory behavior [GO:0007626]; lung alveolus development [GO:0048286]; mitochondrion organization [GO:0007005]; negative regulation of iron ion transmembrane transport [GO:0034760]; neuron projection morphogenesis [GO:0048812]; norepinephrine metabolic process [GO:0042415]; peptidyl-lysine modification [GO:0018205]; pigmentation [GO:0043473]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell size [GO:0045793]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of response to wounding [GO:1903036]; positive regulation of tyrosinase activity [GO:0032773]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; pyramidal neuron development [GO:0021860]; regulation of oxidative phosphorylation [GO:0002082]; removal of superoxide radicals [GO:0019430]; response to iron(III) ion [GO:0010041]; response to manganese ion [GO:0010042]; response to zinc ion [GO:0010043]; serotonin metabolic process [GO:0042428]; skin development [GO:0043588]; T-helper cell differentiation [GO:0042093]; tryptophan metabolic process [GO:0006568]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:10484781, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:9147644, ECO:0000269|PubMed:9467005}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:10484781, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:9147644}; Multi-pass membrane protein {ECO:0000255}. Melanosome membrane {ECO:0000250|UniProtKB:Q64430}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q64430}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P70705}. Cell projection, dendrite {ECO:0000250|UniProtKB:P70705}. Postsynaptic density {ECO:0000250|UniProtKB:P70705}. Note=Cycles constitutively between the TGN and the plasma membrane (PubMed:9147644). Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels. Targeting into melanosomes is regulated by BLOC-1 complex (By similarity). In response to glutamate, translocates to neuron processes with a minor fraction at extrasynaptic sites (By similarity). {ECO:0000250|UniProtKB:P70705, ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:9147644}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Endoplasmic reticulum {ECO:0000269|PubMed:9467005}.
Q04671	reviewed	P_HUMAN	P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog)	OCA2 D15S12 P	Homo sapiens (Human)	838	FUNCTION: Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation (PubMed:25513726, PubMed:11310796, PubMed:15262401, PubMed:22234890). One of the components of the mammalian pigmentary system (PubMed:15262401, PubMed:18252222, PubMed:7601462). May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color (PubMed:15262401, PubMed:18252222, PubMed:7601462). Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis (By similarity). {ECO:0000250|UniProtKB:Q62052, ECO:0000269|PubMed:11310796, ECO:0000269|PubMed:15262401, ECO:0000269|PubMed:18252222, ECO:0000269|PubMed:22234890, ECO:0000269|PubMed:25513726, ECO:0000269|PubMed:7601462}.		cell population proliferation [GO:0008283]; lysosomal lumen pH elevation [GO:0035752]; melanin biosynthetic process [GO:0042438]; melanin biosynthetic process from tyrosine [GO:0006583]; melanocyte differentiation [GO:0030318]; spermatid development [GO:0007286]	endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; melanosome membrane [GO:0033162]	intracellular chloride channel activity [GO:0061778]	endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; melanosome membrane [GO:0033162]; intracellular chloride channel activity [GO:0061778]; cell population proliferation [GO:0008283]; lysosomal lumen pH elevation [GO:0035752]; melanin biosynthetic process [GO:0042438]; melanin biosynthetic process from tyrosine [GO:0006583]; melanocyte differentiation [GO:0030318]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:25513726, ECO:0000269|PubMed:7601462}; Multi-pass membrane protein {ECO:0000269|PubMed:7601462}.
Q04695	reviewed	K1C17_HUMAN	Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17)	KRT17	Homo sapiens (Human)	432	FUNCTION: Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. {ECO:0000250|UniProtKB:Q9QWL7, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:15795121, ECO:0000269|PubMed:16713453}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	epithelial cell differentiation [GO:0030855]; hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; positive regulation of cell growth [GO:0030307]; positive regulation of hair follicle development [GO:0051798]; positive regulation of translation [GO:0045727]	cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]	structural molecule activity [GO:0005198]	cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; positive regulation of cell growth [GO:0030307]; positive regulation of hair follicle development [GO:0051798]; positive regulation of translation [GO:0045727]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QWL7}.
Q04721	reviewed	NOTC2_HUMAN	Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]	NOTCH2	Homo sapiens (Human)	2471	FUNCTION: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}.		animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; atrial septum morphogenesis [GO:0060413]; atrioventricular node development [GO:0003162]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; bone remodeling [GO:0046849]; cell fate determination [GO:0001709]; cellular response to tumor cell [GO:0071228]; cholangiocyte proliferation [GO:1990705]; ciliary body morphogenesis [GO:0061073]; defense response to bacterium [GO:0042742]; embryonic limb morphogenesis [GO:0030326]; glomerular capillary formation [GO:0072104]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; hepatocyte proliferation [GO:0072574]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; inflammatory response to antigenic stimulus [GO:0002437]; intracellular signal transduction [GO:0035556]; intrahepatic bile duct development [GO:0035622]; left/right axis specification [GO:0070986]; marginal zone B cell differentiation [GO:0002315]; morphogenesis of an epithelial sheet [GO:0002011]; multicellular organism growth [GO:0035264]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; placenta blood vessel development [GO:0060674]; podocyte development [GO:0072015]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of Ras protein signal transduction [GO:0046579]; proximal tubule development [GO:0072014]; pulmonary valve morphogenesis [GO:0003184]; regulation of osteoclast development [GO:2001204]; wound healing [GO:0042060]	cell surface [GO:0009986]; cilium [GO:0005929]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; NF-kappaB binding [GO:0051059]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; cilium [GO:0005929]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; NF-kappaB binding [GO:0051059]; signaling receptor activity [GO:0038023]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; atrial septum morphogenesis [GO:0060413]; atrioventricular node development [GO:0003162]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; bone remodeling [GO:0046849]; cell fate determination [GO:0001709]; cellular response to tumor cell [GO:0071228]; cholangiocyte proliferation [GO:1990705]; ciliary body morphogenesis [GO:0061073]; defense response to bacterium [GO:0042742]; embryonic limb morphogenesis [GO:0030326]; glomerular capillary formation [GO:0072104]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; hepatocyte proliferation [GO:0072574]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; inflammatory response to antigenic stimulus [GO:0002437]; intracellular signal transduction [GO:0035556]; intrahepatic bile duct development [GO:0035622]; left/right axis specification [GO:0070986]; marginal zone B cell differentiation [GO:0002315]; morphogenesis of an epithelial sheet [GO:0002011]; multicellular organism growth [GO:0035264]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; placenta blood vessel development [GO:0060674]; podocyte development [GO:0072015]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of Ras protein signal transduction [GO:0046579]; proximal tubule development [GO:0072014]; pulmonary valve morphogenesis [GO:0003184]; regulation of osteoclast development [GO:2001204]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: [Notch 2 extracellular truncation]: Cell membrane {ECO:0000269|PubMed:29329397, ECO:0000269|PubMed:9244302}; Single-pass type I membrane protein {ECO:0000269|PubMed:9244302}.; SUBCELLULAR LOCATION: [Notch 2 intracellular domain]: Nucleus {ECO:0000269|PubMed:25985737}. Cytoplasm {ECO:0000269|PubMed:25985737}. Note=Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by TCIM (PubMed:25985737). {ECO:0000269|PubMed:25985737}.
Q04724	reviewed	TLE1_HUMAN	Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)	TLE1	Homo sapiens (Human)	770	FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000250|UniProtKB:Q62440, ECO:0000269|PubMed:10660609}.		animal organ morphogenesis [GO:0009887]; negative regulation of anoikis [GO:2000811]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gene expression [GO:0010628]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	beta-catenin-TCF complex [GO:1990907]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]	beta-catenin-TCF complex [GO:1990907]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]; animal organ morphogenesis [GO:0009887]; negative regulation of anoikis [GO:2000811]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gene expression [GO:0010628]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12397081}. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
Q04725	reviewed	TLE2_HUMAN	Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)	TLE2	Homo sapiens (Human)	743	FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}.		animal organ morphogenesis [GO:0009887]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	transcription corepressor activity [GO:0003714]	extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription corepressor activity [GO:0003714]; animal organ morphogenesis [GO:0009887]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus.
Q04726	reviewed	TLE3_HUMAN	Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)	TLE3 KIAA1547	Homo sapiens (Human)	772	FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}.		animal organ morphogenesis [GO:0009887]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cold-induced thermogenesis [GO:0120163]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	beta-catenin-TCF complex [GO:1990907]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	transcription corepressor activity [GO:0003714]	beta-catenin-TCF complex [GO:1990907]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription corepressor activity [GO:0003714]; animal organ morphogenesis [GO:0009887]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cold-induced thermogenesis [GO:0120163]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus.
Q04727	reviewed	TLE4_HUMAN	Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)	TLE4 GRG4 KIAA1261	Homo sapiens (Human)	773	FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}.		cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Wnt signaling pathway [GO:0016055]	beta-catenin-TCF complex [GO:1990907]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; transcription corepressor activity [GO:0003714]	beta-catenin-TCF complex [GO:1990907]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; transcription corepressor activity [GO:0003714]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus.
Q04741	reviewed	EMX1_HUMAN	Homeobox protein EMX1 (Empty spiracles homolog 1) (Empty spiracles-like protein 1)	EMX1	Homo sapiens (Human)	290	FUNCTION: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.		brain development [GO:0007420]; brain morphogenesis [GO:0048854]; central nervous system development [GO:0007417]; cerebral cortex neuron differentiation [GO:0021895]; cerebral cortex regionalization [GO:0021796]; homeostasis of number of cells [GO:0048872]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; neuron projection extension [GO:1990138]; post-embryonic development [GO:0009791]; radial glial cell differentiation [GO:0060019]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; brain development [GO:0007420]; brain morphogenesis [GO:0048854]; central nervous system development [GO:0007417]; cerebral cortex neuron differentiation [GO:0021895]; cerebral cortex regionalization [GO:0021796]; homeostasis of number of cells [GO:0048872]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; neuron projection extension [GO:1990138]; post-embryonic development [GO:0009791]; radial glial cell differentiation [GO:0060019]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:20887964}. Cytoplasm {ECO:0000269|PubMed:20887964}. Note=Might be shuttling between the nucleus and the cytoplasm.
Q04743	reviewed	EMX2_HUMAN	Homeobox protein EMX2 (Empty spiracles homolog 2) (Empty spiracles-like protein 2)	EMX2	Homo sapiens (Human)	252	FUNCTION: Transcription factor, which in cooperation with EMX1, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combination with OTX1/2 to specify cell fates in the developing central nervous system.		anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; cell proliferation in forebrain [GO:0021846]; central nervous system development [GO:0007417]; cerebral cortex regionalization [GO:0021796]; dentate gyrus development [GO:0021542]; forebrain cell migration [GO:0021885]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; ureter morphogenesis [GO:0072197]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; cell proliferation in forebrain [GO:0021846]; central nervous system development [GO:0007417]; cerebral cortex regionalization [GO:0021796]; dentate gyrus development [GO:0021542]; forebrain cell migration [GO:0021885]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; ureter morphogenesis [GO:0072197]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q04744}. Cell projection, axon {ECO:0000250|UniProtKB:Q04744}. Note=Detected in axons within the olfactory mucosa and glomeruli in the olfactory bulb. {ECO:0000250|UniProtKB:Q04744}.
Q04756	reviewed	HGFA_HUMAN	Hepatocyte growth factor activator (HGF activator) (HGFA) (EC 3.4.21.-) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain]	HGFAC	Homo sapiens (Human)	655	FUNCTION: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.		blood coagulation [GO:0007596]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; rough endoplasmic reticulum [GO:0005791]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; rough endoplasmic reticulum [GO:0005791]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; blood coagulation [GO:0007596]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
Q04759	reviewed	KPCT_HUMAN	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)	PRKCQ PRKCT	Homo sapiens (Human)	706	FUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:8657160}.		axon guidance [GO:0007411]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell chemotaxis [GO:0060326]; Fc-epsilon receptor signaling pathway [GO:0038095]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell activation [GO:0050870]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of T-helper 2 cell activation [GO:2000570]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of DNA-templated transcription [GO:0006355]; regulation of platelet aggregation [GO:0090330]	aggresome [GO:0016235]; centriolar satellite [GO:0034451]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	aggresome [GO:0016235]; centriolar satellite [GO:0034451]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; axon guidance [GO:0007411]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell chemotaxis [GO:0060326]; Fc-epsilon receptor signaling pathway [GO:0038095]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell activation [GO:0050870]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of T-helper 2 cell activation [GO:2000570]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of DNA-templated transcription [GO:0006355]; regulation of platelet aggregation [GO:0090330]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.
Q04760	reviewed	LGUL_HUMAN	Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase)	GLO1	Homo sapiens (Human)	184	FUNCTION: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:9705294, PubMed:23122816). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CPU0, ECO:0000269|PubMed:19199007, ECO:0000269|PubMed:20454679, ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9705294}.		carbohydrate metabolic process [GO:0005975]; glutathione metabolic process [GO:0006749]; methylglyoxal metabolic process [GO:0009438]; negative regulation of apoptotic process [GO:0043066]; osteoclast differentiation [GO:0030316]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	lactoylglutathione lyase activity [GO:0004462]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; lactoylglutathione lyase activity [GO:0004462]; zinc ion binding [GO:0008270]; carbohydrate metabolic process [GO:0005975]; glutathione metabolic process [GO:0006749]; methylglyoxal metabolic process [GO:0009438]; negative regulation of apoptotic process [GO:0043066]; osteoclast differentiation [GO:0030316]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q04771	reviewed	ACVR1_HUMAN	Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)	ACVR1 ACVRLK2	Homo sapiens (Human)	509	FUNCTION: Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation (PubMed:20628059, PubMed:22977237). As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B (PubMed:17911401). Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain (PubMed:25354296). In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal (PubMed:9748228). In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor (PubMed:17911401). Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity). May promote the expression of HAMP, potentially via its interaction with BMP6 (By similarity). {ECO:0000250|UniProtKB:P15261, ECO:0000250|UniProtKB:P37172, ECO:0000269|PubMed:17911401, ECO:0000269|PubMed:20628059, ECO:0000269|PubMed:22977237, ECO:0000269|PubMed:25354296, ECO:0000269|PubMed:9748228}.		activin receptor signaling pathway [GO:0032924]; acute inflammatory response [GO:0002526]; atrial septum primum morphogenesis [GO:0003289]; atrioventricular valve morphogenesis [GO:0003181]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac muscle cell fate commitment [GO:0060923]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion cell fate commitment [GO:0061445]; endocardial cushion formation [GO:0003272]; endocardial cushion fusion [GO:0003274]; gastrulation with mouth forming second [GO:0001702]; germ cell development [GO:0007281]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of signal transduction [GO:0009968]; neural crest cell migration [GO:0001755]; peptidyl-threonine phosphorylation [GO:0018107]; pharyngeal system development [GO:0060037]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of cell migration [GO:0030335]; positive regulation of determination of dorsal identity [GO:2000017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of ossification [GO:0030278]; smooth muscle cell differentiation [GO:0051145]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular septum morphogenesis [GO:0060412]	activin receptor complex [GO:0048179]; apical part of cell [GO:0045177]; BMP receptor complex [GO:0070724]; plasma membrane [GO:0005886]	activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase binding [GO:1990782]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity, type I [GO:0005025]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]	activin receptor complex [GO:0048179]; apical part of cell [GO:0045177]; BMP receptor complex [GO:0070724]; plasma membrane [GO:0005886]; activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase binding [GO:1990782]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity, type I [GO:0005025]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; activin receptor signaling pathway [GO:0032924]; acute inflammatory response [GO:0002526]; atrial septum primum morphogenesis [GO:0003289]; atrioventricular valve morphogenesis [GO:0003181]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac muscle cell fate commitment [GO:0060923]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion cell fate commitment [GO:0061445]; endocardial cushion formation [GO:0003272]; endocardial cushion fusion [GO:0003274]; gastrulation with mouth forming second [GO:0001702]; germ cell development [GO:0007281]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of signal transduction [GO:0009968]; neural crest cell migration [GO:0001755]; peptidyl-threonine phosphorylation [GO:0018107]; pharyngeal system development [GO:0060037]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of cell migration [GO:0030335]; positive regulation of determination of dorsal identity [GO:2000017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of ossification [GO:0030278]; smooth muscle cell differentiation [GO:0051145]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q04828	reviewed	AK1C1_HUMAN	Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB)	AKR1C1 DDH DDH1	Homo sapiens (Human)	323	FUNCTION: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699}.		bile acid and bile salt transport [GO:0015721]; bile acid metabolic process [GO:0008206]; cellular response to jasmonic acid stimulus [GO:0071395]; cholesterol homeostasis [GO:0042632]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; epithelial cell differentiation [GO:0030855]; intestinal cholesterol absorption [GO:0030299]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; response to organophosphorus [GO:0046683]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity [GO:0047006]; 3beta-hydroxy-5beta-steroid dehydrogenase activity [GO:0033703]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase (B-specific) activity [GO:0047042]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; carboxylic acid binding [GO:0031406]; dihydrotestosterone 17-beta-dehydrogenase activity [GO:0035410]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; indanol dehydrogenase activity [GO:0047718]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; phenanthrene 9,10-monooxygenase activity [GO:0018636]; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0033764]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase [NAD(P)] activity [GO:0030283]; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity [GO:0047006]; 3beta-hydroxy-5beta-steroid dehydrogenase activity [GO:0033703]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; aldo-keto reductase (NADP) activity [GO:0004033]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase (B-specific) activity [GO:0047042]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; carboxylic acid binding [GO:0031406]; dihydrotestosterone 17-beta-dehydrogenase activity [GO:0035410]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; indanol dehydrogenase activity [GO:0047718]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; phenanthrene 9,10-monooxygenase activity [GO:0018636]; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0033764]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase [NAD(P)] activity [GO:0030283]; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115]; bile acid and bile salt transport [GO:0015721]; bile acid metabolic process [GO:0008206]; cellular response to jasmonic acid stimulus [GO:0071395]; cholesterol homeostasis [GO:0042632]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; epithelial cell differentiation [GO:0030855]; intestinal cholesterol absorption [GO:0030299]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; response to organophosphorus [GO:0046683]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:8486699}.
Q04837	reviewed	SSBP_HUMAN	Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17)	SSBP1 SSBP	Homo sapiens (Human)	148	FUNCTION: Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:21953457, PubMed:12975372, PubMed:26446790, PubMed:15167897, PubMed:31550240). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:26446790, PubMed:21953457, PubMed:31550240). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262). {ECO:0000269|PubMed:12975372, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:21953457, ECO:0000269|PubMed:23290262, ECO:0000269|PubMed:26446790, ECO:0000269|PubMed:31550240}.		DNA unwinding involved in DNA replication [GO:0006268]; mitochondrial DNA replication [GO:0006264]; mitochondrion morphogenesis [GO:0070584]; positive regulation of helicase activity [GO:0051096]; positive regulation of mitochondrial DNA replication [GO:0090297]; protein homotetramerization [GO:0051289]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; DNA unwinding involved in DNA replication [GO:0006268]; mitochondrial DNA replication [GO:0006264]; mitochondrion morphogenesis [GO:0070584]; positive regulation of helicase activity [GO:0051096]; positive regulation of mitochondrial DNA replication [GO:0090297]; protein homotetramerization [GO:0051289]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:31550237, ECO:0000269|PubMed:31550240}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:31550240}.
Q04844	reviewed	ACHE_HUMAN	Acetylcholine receptor subunit epsilon	CHRNE ACHRE	Homo sapiens (Human)	493	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. {ECO:0000269|PubMed:27375219}.		muscle contraction [GO:0006936]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; monoatomic cation transmembrane transporter activity [GO:0008324]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; monoatomic cation transmembrane transporter activity [GO:0008324]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; muscle contraction [GO:0006936]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Q04864	reviewed	REL_HUMAN	Proto-oncogene c-Rel	REL	Homo sapiens (Human)	619	FUNCTION: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.		canonical NF-kappaB signal transduction [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of interferon-beta production [GO:0032688]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cytokine [GO:0034097]	chromatin [GO:0000785]; cytosol [GO:0005829]; NF-kappaB complex [GO:0071159]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; NF-kappaB complex [GO:0071159]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; canonical NF-kappaB signal transduction [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of interferon-beta production [GO:0032688]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cytokine [GO:0034097]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q04900	reviewed	MUC24_HUMAN	Sialomucin core protein 24 (MUC-24) (Endolyn) (Multi-glycosylated core protein 24) (MGC-24) (MGC-24v) (CD antigen CD164)	CD164	Homo sapiens (Human)	197	FUNCTION: Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity). {ECO:0000250|UniProtKB:Q9R0L9, ECO:0000269|PubMed:16859559, ECO:0000269|PubMed:17077324, ECO:0000269|PubMed:9763543}.		cell adhesion [GO:0007155]; hemopoiesis [GO:0030097]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955]; muscle organ development [GO:0007517]; negative regulation of cell adhesion [GO:0007162]; signal transduction [GO:0007165]	endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]		endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; cell adhesion [GO:0007155]; hemopoiesis [GO:0030097]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955]; muscle organ development [GO:0007517]; negative regulation of cell adhesion [GO:0007162]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:11027692}; Single-pass type I membrane protein {ECO:0000269|PubMed:11027692}. Endosome membrane {ECO:0000269|PubMed:11027692}; Single-pass type I membrane protein {ECO:0000269|PubMed:11027692}. Cell membrane {ECO:0000269|PubMed:11027692, ECO:0000269|PubMed:26197441}; Single-pass type I membrane protein {ECO:0000269|PubMed:11027692}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q04912	reviewed	RON_HUMAN	Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]	MST1R PTK8 RON	Homo sapiens (Human)	1400	FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. {ECO:0000269|PubMed:18836480, ECO:0000269|PubMed:7939629, ECO:0000269|PubMed:9764835}.	MISCELLANEOUS: [Isoform Delta-RON]: Lacks part of the extracellular domain, oligomerizes and is constitutively activated. Expressed at higher level in cancer cells. {ECO:0000303|PubMed:26951679}.	cell migration [GO:0016477]; defense response [GO:0006952]; innate immune response [GO:0045087]; nervous system development [GO:0007399]; phagocytosis [GO:0006909]; phosphorylation [GO:0016310]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; response to virus [GO:0009615]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; stress fiber [GO:0001725]; vacuole [GO:0005773]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; macrophage colony-stimulating factor receptor activity [GO:0005011]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; stress fiber [GO:0001725]; vacuole [GO:0005773]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; macrophage colony-stimulating factor receptor activity [GO:0005011]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; cell migration [GO:0016477]; defense response [GO:0006952]; innate immune response [GO:0045087]; nervous system development [GO:0007399]; phagocytosis [GO:0006909]; phosphorylation [GO:0016310]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; response to virus [GO:0009615]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q04917	reviewed	1433F_HUMAN	14-3-3 protein eta (Protein AS1)	YWHAH YWHA1	Homo sapiens (Human)	246	FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.		glucocorticoid catabolic process [GO:0006713]; glucocorticoid receptor signaling pathway [GO:0042921]; intracellular protein transport [GO:0006886]; membrane depolarization during action potential [GO:0086010]; negative regulation of dendrite morphogenesis [GO:0050774]; positive regulation of DNA-templated transcription [GO:0045893]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of neuron differentiation [GO:0045664]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of sodium ion transport [GO:0002028]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762]	cerebellar granule cell to Purkinje cell synapse [GO:0150048]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	actin binding [GO:0003779]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; insulin-like growth factor receptor binding [GO:0005159]; nuclear glucocorticoid receptor binding [GO:0035259]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]	cerebellar granule cell to Purkinje cell synapse [GO:0150048]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; actin binding [GO:0003779]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; insulin-like growth factor receptor binding [GO:0005159]; nuclear glucocorticoid receptor binding [GO:0035259]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; glucocorticoid catabolic process [GO:0006713]; glucocorticoid receptor signaling pathway [GO:0042921]; intracellular protein transport [GO:0006886]; membrane depolarization during action potential [GO:0086010]; negative regulation of dendrite morphogenesis [GO:0050774]; positive regulation of DNA-templated transcription [GO:0045893]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of neuron differentiation [GO:0045664]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of sodium ion transport [GO:0002028]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762]	
Q04941	reviewed	PLP2_HUMAN	Proteolipid protein 2 (Differentiation-dependent protein A4) (Intestinal membrane A4 protein)	PLP2 A4	Homo sapiens (Human)	152	FUNCTION: May play a role in cell differentiation in the intestinal epithelium.		chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; monoatomic ion transport [GO:0006811]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	chemokine binding [GO:0019956]; monoatomic ion transmembrane transporter activity [GO:0015075]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; chemokine binding [GO:0019956]; monoatomic ion transmembrane transporter activity [GO:0015075]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; monoatomic ion transport [GO:0006811]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q05066	reviewed	SRY_HUMAN	Sex-determining region Y protein (Testis-determining factor)	SRY TDF	Homo sapiens (Human)	204	FUNCTION: Transcriptional regulator that controls a genetic switch in male development (PubMed:11563911). It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed:16996051, PubMed:16414182). Involved in different aspects of gene regulation including promoter activation or repression (PubMed:9525897). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (PubMed:1425584, PubMed:8265659, PubMed:8159753, PubMed:11563911, PubMed:15170344). SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (PubMed:1425584, PubMed:8265659, PubMed:8159753, PubMed:11563911, PubMed:15170344, PubMed:16762365). Also involved in pre-mRNA splicing (PubMed:11818535). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). {ECO:0000250|UniProtKB:P36394, ECO:0000269|PubMed:11563911, ECO:0000269|PubMed:11818535, ECO:0000269|PubMed:1425584, ECO:0000269|PubMed:15170344, ECO:0000269|PubMed:16762365, ECO:0000269|PubMed:8159753, ECO:0000269|PubMed:8265659, ECO:0000269|PubMed:9525897, ECO:0000303|PubMed:16414182, ECO:0000303|PubMed:16996051}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; male sex determination [GO:0030238]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sex differentiation [GO:0007548]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	calmodulin binding [GO:0005516]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; calmodulin binding [GO:0005516]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; male sex determination [GO:0030238]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sex differentiation [GO:0007548]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11818535}. Cytoplasm {ECO:0000269|PubMed:15297880, ECO:0000269|PubMed:19349578}. Nucleus {ECO:0000269|PubMed:15297880, ECO:0000269|PubMed:15746192, ECO:0000269|PubMed:16762365, ECO:0000269|PubMed:19349578, ECO:0000269|PubMed:28030592}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (PubMed:15297880). Colocalizes with SOX6 in speckles (PubMed:11818535). Colocalizes with CAML in the nucleus (PubMed:15746192). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (PubMed:19349578). {ECO:0000250|UniProtKB:Q05738, ECO:0000269|PubMed:11818535, ECO:0000269|PubMed:15297880, ECO:0000269|PubMed:15746192, ECO:0000269|PubMed:19349578}.
Q05084	reviewed	ICA69_HUMAN	Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69)	ICA1	Homo sapiens (Human)	483	FUNCTION: May play a role in neurotransmitter secretion. {ECO:0000250}.		neurotransmitter transport [GO:0006836]; regulation of transport [GO:0051049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]	membrane curvature sensor activity [GO:0140090]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]; membrane curvature sensor activity [GO:0140090]; protein domain specific binding [GO:0019904]; neurotransmitter transport [GO:0006836]; regulation of transport [GO:0051049]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12682071}. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.
Q05086	reviewed	UBE3A_HUMAN	Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)	UBE3A E6AP EPVE6AP HPVE6A	Homo sapiens (Human)	875	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990, PubMed:30020076). Several substrates have been identified including the BMAL1, ARC, LAMTOR1, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990, PubMed:30020076). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Required for synaptic remodeling in neurons by mediating ubiquitination and degradation of LAMTOR1, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:O08759, ECO:0000269|PubMed:10373495, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:19204938, ECO:0000269|PubMed:19233847, ECO:0000269|PubMed:19325566, ECO:0000269|PubMed:19591933, ECO:0000269|PubMed:22645313, ECO:0000269|PubMed:24273172, ECO:0000269|PubMed:24728990, ECO:0000269|PubMed:30020076}.; FUNCTION: (Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. {ECO:0000269|PubMed:8380895}.	MISCELLANEOUS: A cysteine residue is required for ubiquitin-thioester formation.	androgen receptor signaling pathway [GO:0030521]; brain development [GO:0007420]; negative regulation of TORC1 signaling [GO:1904262]; ovarian follicle development [GO:0001541]; positive regulation of Golgi lumen acidification [GO:1905528]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; prostate gland growth [GO:0060736]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; proteolysis [GO:0006508]; regulation of circadian rhythm [GO:0042752]; regulation of synaptic plasticity [GO:0048167]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to progesterone [GO:0032570]; rhythmic process [GO:0048511]; sperm entry [GO:0035037]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; proteasome complex [GO:0000502]	metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; androgen receptor signaling pathway [GO:0030521]; brain development [GO:0007420]; negative regulation of TORC1 signaling [GO:1904262]; ovarian follicle development [GO:0001541]; positive regulation of Golgi lumen acidification [GO:1905528]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; prostate gland growth [GO:0060736]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; proteolysis [GO:0006508]; regulation of circadian rhythm [GO:0042752]; regulation of synaptic plasticity [GO:0048167]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to progesterone [GO:0032570]; rhythmic process [GO:0048511]; sperm entry [GO:0035037]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O08759}. Nucleus {ECO:0000250|UniProtKB:O08759}.
Q05193	reviewed	DYN1_HUMAN	Dynamin-1 (EC 3.6.5.5)	DNM1 DNM	Homo sapiens (Human)	864	FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.		endocytosis [GO:0006897]; endosome organization [GO:0007032]; modulation of chemical synaptic transmission [GO:0050804]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]; synaptic vesicle endocytosis [GO:0048488]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; membrane coat [GO:0030117]; microtubule [GO:0005874]; photoreceptor inner segment [GO:0001917]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynaptic endocytic zone membrane [GO:0098835]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; membrane coat [GO:0030117]; microtubule [GO:0005874]; photoreceptor inner segment [GO:0001917]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynaptic endocytic zone membrane [GO:0098835]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; modulation of chemical synaptic transmission [GO:0050804]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15703209}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15703209}. Note=Microtubule-associated.
Q05195	reviewed	MAD1_HUMAN	Max dimerization protein 1 (Max dimerizer 1) (Protein MAD)	MXD1 MAD	Homo sapiens (Human)	221	FUNCTION: Component of a transcriptional repressor complex together with MAX (PubMed:8425218). In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218). Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218). Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246). {ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:8425218}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; Mad-Max complex [GO:0070443]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; Mad-Max complex [GO:0070443]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:8425218}.
Q05209	reviewed	PTN12_HUMAN	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)	PTPN12	Homo sapiens (Human)	780	FUNCTION: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}.		cellular response to epidermal growth factor stimulus [GO:0071364]; negative regulation of ERBB signaling pathway [GO:1901185]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; tissue regeneration [GO:0042246]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102]	non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; SH3 domain binding [GO:0017124]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; SH3 domain binding [GO:0017124]; cellular response to epidermal growth factor stimulus [GO:0071364]; negative regulation of ERBB signaling pathway [GO:1901185]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P35831}. Cell junction, focal adhesion {ECO:0000269|PubMed:18559503}. Cell projection, podosome {ECO:0000250|UniProtKB:P35831}. Note=Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2. {ECO:0000269|PubMed:18559503}.
Q05215	reviewed	EGR4_HUMAN	Early growth response protein 4 (EGR-4) (AT133)	EGR4	Homo sapiens (Human)	589	FUNCTION: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity). {ECO:0000250}.		positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q05315	reviewed	LEG10_HUMAN	Galectin-10 (Gal-10) (Charcot-Leyden crystal protein) (CLC) (Eosinophil lysophospholipase) (Lysolecithin acylhydrolase)	CLC LGALS10 LGALS10A	Homo sapiens (Human)	142	FUNCTION: Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). {ECO:0000269|PubMed:17502455}.	MISCELLANEOUS: Forms hexagonal bipyramidal crystals, known as Charcot-Leyden crystals, in tissues and secretions from sites of eosinophil-associated inflammation and some myeloid leukemias.	regulation of activated T cell proliferation [GO:0046006]; regulation of T cell anergy [GO:0002667]; regulation of T cell cytokine production [GO:0002724]; T cell apoptotic process [GO:0070231]	collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]	carbohydrate binding [GO:0030246]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; identical protein binding [GO:0042802]	collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; carbohydrate binding [GO:0030246]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; identical protein binding [GO:0042802]; regulation of activated T cell proliferation [GO:0046006]; regulation of T cell anergy [GO:0002667]; regulation of T cell cytokine production [GO:0002724]; T cell apoptotic process [GO:0070231]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17502455}. Cytoplasmic granule {ECO:0000269|PubMed:17502455}. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.
Q05329	reviewed	DCE2_HUMAN	Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform)	GAD2 GAD65	Homo sapiens (Human)	585	FUNCTION: Catalyzes the production of GABA. {ECO:0000305|PubMed:8999827}.		chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; glutamate decarboxylation to succinate [GO:0006540]; neurotransmitter biosynthetic process [GO:0042136]; response to xenobiotic stimulus [GO:0009410]	axon [GO:0030424]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; Golgi membrane [GO:0000139]; inhibitory synapse [GO:0060077]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]	glutamate binding [GO:0016595]; glutamate decarboxylase activity [GO:0004351]; protein-containing complex binding [GO:0044877]; pyridoxal phosphate binding [GO:0030170]	axon [GO:0030424]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; Golgi membrane [GO:0000139]; inhibitory synapse [GO:0060077]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; glutamate binding [GO:0016595]; glutamate decarboxylase activity [GO:0004351]; protein-containing complex binding [GO:0044877]; pyridoxal phosphate binding [GO:0030170]; chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; glutamate decarboxylation to succinate [GO:0006540]; neurotransmitter biosynthetic process [GO:0042136]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12356867}. Cytoplasmic vesicle {ECO:0000269|PubMed:12356867}. Presynaptic cell membrane {ECO:0000269|PubMed:12356867}; Lipid-anchor {ECO:0000269|PubMed:12356867}. Golgi apparatus membrane {ECO:0000269|PubMed:12356867}; Peripheral membrane protein {ECO:0000269|PubMed:12356867}; Cytoplasmic side {ECO:0000269|PubMed:12356867}. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
Q05397	reviewed	FAK1_HUMAN	Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)	PTK2 FAK FAK1	Homo sapiens (Human)	1052	FUNCTION: Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}.	MISCELLANEOUS: [Isoform 6]: Produced by alternative promoter usage. {ECO:0000305}.	angiogenesis [GO:0001525]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cell motility [GO:0048870]; detection of muscle stretch [GO:0035995]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of cell polarity [GO:0030010]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; growth hormone receptor signaling pathway [GO:0060396]; heart morphogenesis [GO:0003007]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-cell adhesion [GO:0022408]; netrin-activated signaling pathway [GO:0038007]; peptidyl-tyrosine phosphorylation [GO:0018108]; placenta development [GO:0001890]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of wound healing [GO:0090303]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; regulation of endothelial cell migration [GO:0010594]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of osteoblast differentiation [GO:0045667]; regulation of protein phosphorylation [GO:0001932]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; signal complex assembly [GO:0007172]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	cell cortex [GO:0005938]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	actin binding [GO:0003779]; ATP binding [GO:0005524]; integrin binding [GO:0005178]; JUN kinase binding [GO:0008432]; molecular function activator activity [GO:0140677]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine phosphatase activity [GO:0004725]; SH2 domain binding [GO:0042169]	cell cortex [GO:0005938]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; actin binding [GO:0003779]; ATP binding [GO:0005524]; integrin binding [GO:0005178]; JUN kinase binding [GO:0008432]; molecular function activator activity [GO:0140677]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine phosphatase activity [GO:0004725]; SH2 domain binding [GO:0042169]; angiogenesis [GO:0001525]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cell motility [GO:0048870]; detection of muscle stretch [GO:0035995]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of cell polarity [GO:0030010]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; growth hormone receptor signaling pathway [GO:0060396]; heart morphogenesis [GO:0003007]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-cell adhesion [GO:0022408]; netrin-activated signaling pathway [GO:0038007]; peptidyl-tyrosine phosphorylation [GO:0018108]; placenta development [GO:0001890]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of wound healing [GO:0090303]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; regulation of endothelial cell migration [GO:0010594]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of osteoblast differentiation [GO:0045667]; regulation of protein phosphorylation [GO:0001932]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; signal complex assembly [GO:0007172]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:15855171, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:31630787}. Cell membrane {ECO:0000250|UniProtKB:Q00944}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q00944}; Cytoplasmic side {ECO:0000250|UniProtKB:Q00944}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15855171}. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O35346}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000269|PubMed:15855171, ECO:0000269|PubMed:18206965}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:31630787}. Cytoplasm {ECO:0000269|PubMed:15855171, ECO:0000269|PubMed:18078954, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281}. Note=Constituent of focal adhesions. Detected at microtubules. {ECO:0000250|UniProtKB:P34152}.
Q05469	reviewed	LIPS_HUMAN	Hormone-sensitive lipase (HSL) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (EC 3.1.1.23) (Retinyl ester hydrolase) (REH)	LIPE	Homo sapiens (Human)	1076	FUNCTION: Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed:8812477, PubMed:15955102, PubMed:15716583, PubMed:19800417). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs (PubMed:19800417). Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity). {ECO:0000250|UniProtKB:P15304, ECO:0000250|UniProtKB:P54310, ECO:0000269|PubMed:15716583, ECO:0000269|PubMed:15955102, ECO:0000269|PubMed:19800417, ECO:0000269|PubMed:8812477}.		cholesterol metabolic process [GO:0008203]; diacylglycerol catabolic process [GO:0046340]; ether lipid metabolic process [GO:0046485]; lipid catabolic process [GO:0016042]; protein phosphorylation [GO:0006468]; triglyceride catabolic process [GO:0019433]	caveola [GO:0005901]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]	1,2-diacylglycerol acylhydrolase activity [GO:0102259]; 1,3-diacylglycerol acylhydrolase activity [GO:0102258]; acylglycerol lipase activity [GO:0047372]; all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; hormone-sensitive lipase activity [GO:0033878]; retinyl-palmitate esterase activity [GO:0050253]; sterol esterase activity [GO:0004771]; triglyceride lipase activity [GO:0004806]	caveola [GO:0005901]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; 1,2-diacylglycerol acylhydrolase activity [GO:0102259]; 1,3-diacylglycerol acylhydrolase activity [GO:0102258]; acylglycerol lipase activity [GO:0047372]; all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; hormone-sensitive lipase activity [GO:0033878]; retinyl-palmitate esterase activity [GO:0050253]; sterol esterase activity [GO:0004771]; triglyceride lipase activity [GO:0004806]; cholesterol metabolic process [GO:0008203]; diacylglycerol catabolic process [GO:0046340]; ether lipid metabolic process [GO:0046485]; lipid catabolic process [GO:0016042]; protein phosphorylation [GO:0006468]; triglyceride catabolic process [GO:0019433]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17026959}. Membrane, caveola {ECO:0000269|PubMed:16803459, ECO:0000269|PubMed:17026959}. Cytoplasm, cytosol {ECO:0000269|PubMed:17026959}. Lipid droplet {ECO:0000250|UniProtKB:P54310}. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Phosphorylation by AMPK reduces its translocation towards the lipid droplets (By similarity). {ECO:0000250|UniProtKB:P54310, ECO:0000269|PubMed:17026959}.
Q05481	reviewed	ZNF91_HUMAN	Zinc finger protein 91 (Zinc finger protein HPF7) (Zinc finger protein HTF10)	ZNF91	Homo sapiens (Human)	1191	FUNCTION: Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidence is required to confirm this result in vivo (PubMed:11470777). {ECO:0000269|PubMed:25274305, ECO:0000305|PubMed:11470777}.	MISCELLANEOUS: ZNF91 is only present in primates and emerged in the last common ancestor of humans and Old-World monkeys. It underwent structural changes between 8-12 Million years ago, probably to improve the protein's ability to bind and repress SINE-VNTR-Alu (SVA) retrotransposons elements (PubMed:25274305). {ECO:0000269|PubMed:25274305, ECO:0000305|PubMed:16606703, ECO:0000305|PubMed:7479878}.	regulation of transcription by RNA polymerase II [GO:0006357]; retrotransposon silencing [GO:0010526]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of transcription by RNA polymerase II [GO:0006357]; retrotransposon silencing [GO:0010526]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23665872}.
Q05513	reviewed	KPCZ_HUMAN	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)	PRKCZ PKC2	Homo sapiens (Human)	592	FUNCTION: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000250|UniProtKB:P09217}.	cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; cellular response to insulin stimulus [GO:0032869]; establishment of cell polarity [GO:0030010]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; membrane depolarization [GO:0051899]; membrane hyperpolarization [GO:0060081]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of apoptotic process [GO:0043066]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of protein-containing complex assembly [GO:0031333]; neuron projection extension [GO:1990138]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein transport [GO:0051222]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; protein kinase C signaling [GO:0070528]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; signal transduction [GO:0007165]; vesicle transport along microtubule [GO:0047496]	apical cortex [GO:0045179]; apical plasma membrane [GO:0016324]; axon hillock [GO:0043203]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; myelin sheath abaxonal region [GO:0035748]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; PAR polarity complex [GO:0120157]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; Schaffer collateral - CA1 synapse [GO:0098685]; stress fiber [GO:0001725]; tight junction [GO:0070160]; vesicle [GO:0031982]	14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; phospholipase binding [GO:0043274]; potassium channel regulator activity [GO:0015459]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	apical cortex [GO:0045179]; apical plasma membrane [GO:0016324]; axon hillock [GO:0043203]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; myelin sheath abaxonal region [GO:0035748]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; PAR polarity complex [GO:0120157]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; Schaffer collateral - CA1 synapse [GO:0098685]; stress fiber [GO:0001725]; tight junction [GO:0070160]; vesicle [GO:0031982]; 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; phospholipase binding [GO:0043274]; potassium channel regulator activity [GO:0015459]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; cellular response to insulin stimulus [GO:0032869]; establishment of cell polarity [GO:0030010]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; membrane depolarization [GO:0051899]; membrane hyperpolarization [GO:0060081]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of apoptotic process [GO:0043066]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of protein-containing complex assembly [GO:0031333]; neuron projection extension [GO:1990138]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein transport [GO:0051222]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; protein kinase C signaling [GO:0070528]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; signal transduction [GO:0007165]; vesicle transport along microtubule [GO:0047496]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:9566925}. Endosome {ECO:0000269|PubMed:9566925}. Cell junction {ECO:0000269|PubMed:7597083}. Membrane {ECO:0000250|UniProtKB:P09217}; Peripheral membrane protein {ECO:0000305}. Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes (PubMed:9566925). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (PubMed:7597083). Colocalizes with VAMP2 and WDFY2 in intracellular vesicles (PubMed:17313651). Transiently translocates to the membrane of CA1 hippocampal cells in response to the induction of long term potentiation (By similarity). {ECO:0000250|UniProtKB:P09217, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:7597083, ECO:0000269|PubMed:9566925}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:P09217}.
Q05516	reviewed	ZBT16_HUMAN	Zinc finger and BTB domain-containing protein 16 (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145) (Zinc finger protein PLZF)	ZBTB16 PLZF ZNF145	Homo sapiens (Human)	673	FUNCTION: Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). {ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:24359566}.		anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; cartilage development [GO:0051216]; cell population proliferation [GO:0008283]; central nervous system development [GO:0007417]; embryonic digit morphogenesis [GO:0042733]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic pattern specification [GO:0009880]; forelimb morphogenesis [GO:0035136]; hemopoiesis [GO:0030097]; male germ-line stem cell asymmetric division [GO:0048133]; mesonephros development [GO:0001823]; myeloid cell differentiation [GO:0030099]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification involved in bone maturation [GO:0043931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of ossification [GO:0045778]; protein localization to nucleus [GO:0034504]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]; type 2 angiotensin receptor binding [GO:0031703]	cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]; type 2 angiotensin receptor binding [GO:0031703]; anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; cartilage development [GO:0051216]; cell population proliferation [GO:0008283]; central nervous system development [GO:0007417]; embryonic digit morphogenesis [GO:0042733]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic pattern specification [GO:0009880]; forelimb morphogenesis [GO:0035136]; hemopoiesis [GO:0030097]; male germ-line stem cell asymmetric division [GO:0048133]; mesonephros development [GO:0001823]; myeloid cell differentiation [GO:0030099]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification involved in bone maturation [GO:0043931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of ossification [GO:0045778]; protein localization to nucleus [GO:0034504]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24359566}. Nucleus, nuclear body {ECO:0000269|PubMed:24359566}.
Q05519	reviewed	SRS11_HUMAN	Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11)	SRSF11 SFRS11	Homo sapiens (Human)	484	FUNCTION: May function in pre-mRNA splicing.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with spliceosome components.
Q05586	reviewed	NMDZ1_HUMAN	Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)	GRIN1 NMDAR1	Homo sapiens (Human)	938	FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761). {ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:7685113}.		brain development [GO:0007420]; calcium ion homeostasis [GO:0055074]; calcium ion transmembrane import into cytosol [GO:0097553]; chemical synaptic transmission [GO:0007268]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; ionotropic glutamate receptor signaling pathway [GO:0035235]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transcription by RNA polymerase II [GO:0045944]; propylene metabolic process [GO:0018964]; protein heterotetramerization [GO:0051290]; regulation of membrane potential [GO:0042391]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to ethanol [GO:0045471]; response to glycine [GO:1905429]; visual learning [GO:0008542]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; excitatory synapse [GO:0060076]; neuron projection [GO:0043005]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic cleft [GO:0043083]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195]	amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; glycine binding [GO:0016594]; ligand-gated monoatomic ion channel activity [GO:0015276]; neurotransmitter binding [GO:0042165]; NMDA glutamate receptor activity [GO:0004972]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; excitatory synapse [GO:0060076]; neuron projection [GO:0043005]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic cleft [GO:0043083]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195]; amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; glycine binding [GO:0016594]; ligand-gated monoatomic ion channel activity [GO:0015276]; neurotransmitter binding [GO:0042165]; NMDA glutamate receptor activity [GO:0004972]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; brain development [GO:0007420]; calcium ion homeostasis [GO:0055074]; calcium ion transmembrane import into cytosol [GO:0097553]; chemical synaptic transmission [GO:0007268]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; ionotropic glutamate receptor signaling pathway [GO:0035235]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transcription by RNA polymerase II [GO:0045944]; propylene metabolic process [GO:0018964]; protein heterotetramerization [GO:0051290]; regulation of membrane potential [GO:0042391]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to ethanol [GO:0045471]; response to glycine [GO:1905429]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:7685113}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}. Postsynaptic density {ECO:0000250}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. {ECO:0000250}.
Q05639	reviewed	EF1A2_HUMAN	Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1)	EEF1A2 EEF1AL STN	Homo sapiens (Human)	463	FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.		positive regulation of apoptotic process [GO:0043065]; positive regulation of lipid kinase activity [GO:0090218]; regulation of chaperone-mediated autophagy [GO:1904714]; translation [GO:0006412]; translational elongation [GO:0006414]	cytoplasm [GO:0005737]; cytoplasmic side of lysosomal membrane [GO:0098574]; eukaryotic translation elongation factor 1 complex [GO:0005853]; synapse [GO:0045202]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; translation elongation factor activity [GO:0003746]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; cytoplasmic side of lysosomal membrane [GO:0098574]; eukaryotic translation elongation factor 1 complex [GO:0005853]; synapse [GO:0045202]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; translation elongation factor activity [GO:0003746]; translation factor activity, RNA binding [GO:0008135]; positive regulation of apoptotic process [GO:0043065]; positive regulation of lipid kinase activity [GO:0090218]; regulation of chaperone-mediated autophagy [GO:1904714]; translation [GO:0006412]; translational elongation [GO:0006414]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q05655	reviewed	KPCD_HUMAN	Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]	PRKCD PKCD	Homo sapiens (Human)	676	FUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21810427, PubMed:21406692). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21810427, PubMed:21406692). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21810427, PubMed:21406692). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21810427, PubMed:21406692). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}.	MISCELLANEOUS: [Isoform 2]: Antiapoptotic isoform, resistant to caspase-3 cleavage. {ECO:0000305}.	activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; B cell proliferation [GO:0042100]; cell chemotaxis [GO:0060326]; cell cycle [GO:0007049]; cellular response to angiotensin [GO:1904385]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hydroperoxide [GO:0071447]; cellular response to UV [GO:0034644]; cellular senescence [GO:0090398]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immunoglobulin mediated immune response [GO:0016064]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein binding [GO:0032091]; neutrophil activation [GO:0042119]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of glucosylceramide catabolic process [GO:2000753]; positive regulation of phospholipid scramblase activity [GO:1900163]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sphingomyelin catabolic process [GO:2000755]; positive regulation of superoxide anion generation [GO:0032930]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of ceramide biosynthetic process [GO:2000303]; regulation of mRNA stability [GO:0043488]; regulation of signaling receptor activity [GO:0010469]; signal transduction [GO:0007165]; termination of signal transduction [GO:0023021]	azurophil granule lumen [GO:0035578]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endolysosome [GO:0036019]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; calcium-independent protein kinase C activity [GO:0004699]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	azurophil granule lumen [GO:0035578]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endolysosome [GO:0036019]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; calcium-independent protein kinase C activity [GO:0004699]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; B cell proliferation [GO:0042100]; cell chemotaxis [GO:0060326]; cell cycle [GO:0007049]; cellular response to angiotensin [GO:1904385]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hydroperoxide [GO:0071447]; cellular response to UV [GO:0034644]; cellular senescence [GO:0090398]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immunoglobulin mediated immune response [GO:0016064]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein binding [GO:0032091]; neutrophil activation [GO:0042119]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of glucosylceramide catabolic process [GO:2000753]; positive regulation of phospholipid scramblase activity [GO:1900163]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sphingomyelin catabolic process [GO:2000755]; positive regulation of superoxide anion generation [GO:0032930]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of ceramide biosynthetic process [GO:2000303]; regulation of mRNA stability [GO:0043488]; regulation of signaling receptor activity [GO:0010469]; signal transduction [GO:0007165]; termination of signal transduction [GO:0023021]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:17603046, ECO:0000269|PubMed:18285462}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:17603046}. Nucleus {ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:17603046, ECO:0000269|PubMed:18285462}. Cell membrane {ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:17603046}; Peripheral membrane protein {ECO:0000305|PubMed:17603046}. Mitochondrion {ECO:0000269|PubMed:12649167}. Endomembrane system {ECO:0000269|PubMed:17303575}. Note=Translocates to the mitochondria upon apoptotic stimulation. Upon activation, translocates to the plasma membrane followed by partial location to the endolysosomes (PubMed:17303575). {ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:17303575}.
Q05682	reviewed	CALD1_HUMAN	Caldesmon (CDM)	CALD1 CAD CDM	Homo sapiens (Human)	793	FUNCTION: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}.		actin filament bundle assembly [GO:0051017]; angiogenesis [GO:0001525]; muscle contraction [GO:0006936]	actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; myofibril [GO:0030016]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; myosin binding [GO:0017022]; tropomyosin binding [GO:0005523]	actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; myosin binding [GO:0017022]; tropomyosin binding [GO:0005523]; actin filament bundle assembly [GO:0051017]; angiogenesis [GO:0001525]; muscle contraction [GO:0006936]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P13505}. Cytoplasm, myofibril {ECO:0000250|UniProtKB:P13505}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:P13505}. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). {ECO:0000250|UniProtKB:P13505}.
Q05707	reviewed	COEA1_HUMAN	Collagen alpha-1(XIV) chain (Undulin)	COL14A1 UND	Homo sapiens (Human)	1796	FUNCTION: Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:2187872}.		cell-cell adhesion [GO:0098609]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]	collagen trimer [GO:0005581]; collagen type XIV trimer [GO:0005596]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interstitial matrix [GO:0005614]	collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]	collagen trimer [GO:0005581]; collagen type XIV trimer [GO:0005596]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interstitial matrix [GO:0005614]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; cell-cell adhesion [GO:0098609]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P32018}.
Q05823	reviewed	RN5A_HUMAN	2-5A-dependent ribonuclease (2-5A-dependent RNase) (EC 3.1.26.-) (Ribonuclease 4) (Ribonuclease L) (RNase L)	RNASEL RNS4	Homo sapiens (Human)	741	FUNCTION: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length. {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:26263979}.		defense response to virus [GO:0051607]; fat cell differentiation [GO:0045444]; mRNA processing [GO:0006397]; negative regulation of viral genome replication [GO:0045071]; positive regulation of glucose import [GO:0046326]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of mRNA stability [GO:0043488]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nuclear matrix [GO:0016363]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA nuclease activity [GO:0004540]; rRNA binding [GO:0019843]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nuclear matrix [GO:0016363]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA nuclease activity [GO:0004540]; rRNA binding [GO:0019843]; defense response to virus [GO:0051607]; fat cell differentiation [GO:0045444]; mRNA processing [GO:0006397]; negative regulation of viral genome replication [GO:0045071]; positive regulation of glucose import [GO:0046326]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of mRNA stability [GO:0043488]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}.
Q05901	reviewed	ACHB3_HUMAN	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	Homo sapiens (Human)	458	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.		presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]	acetylcholine binding [GO:0042166]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]; heterocyclic compound binding [GO:1901363]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; acetylcholine binding [GO:0042166]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]; heterocyclic compound binding [GO:1901363]; transmembrane signaling receptor activity [GO:0004888]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Q05923	reviewed	DUS2_HUMAN	Dual specificity protein phosphatase 2 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PAC-1)	DUSP2 PAC1	Homo sapiens (Human)	314	FUNCTION: Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine (PubMed:8107850). Can dephosphorylate MAPK1 (By similarity). {ECO:0000250|UniProtKB:Q05922, ECO:0000269|PubMed:8107850}.		endoderm formation [GO:0001706]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; mitogen-activated protein kinase binding [GO:0051019]; myosin phosphatase activity [GO:0017018]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/threonine phosphatase activity [GO:0008330]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; mitogen-activated protein kinase binding [GO:0051019]; myosin phosphatase activity [GO:0017018]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/threonine phosphatase activity [GO:0008330]; endoderm formation [GO:0001706]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Nucleus.
Q05925	reviewed	HME1_HUMAN	Homeobox protein engrailed-1 (Homeobox protein en-1) (Hu-En-1)	EN1	Homo sapiens (Human)	392	FUNCTION: Required for proper formation of the apical ectodermal ridge and correct dorsal-ventral patterning in the limb. {ECO:0000250|UniProtKB:P09065}.		adult locomotory behavior [GO:0008344]; anatomical structure morphogenesis [GO:0009653]; cerebellum development [GO:0021549]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral pattern formation [GO:0009953]; drinking behavior [GO:0042756]; embryonic brain development [GO:1990403]; embryonic forelimb morphogenesis [GO:0035115]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; motor learning [GO:0061743]; multicellular organism growth [GO:0035264]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; pigmentation [GO:0043473]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cocaine [GO:0042220]; skeletal system development [GO:0001501]; social behavior [GO:0035176]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; adult locomotory behavior [GO:0008344]; anatomical structure morphogenesis [GO:0009653]; cerebellum development [GO:0021549]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral pattern formation [GO:0009953]; drinking behavior [GO:0042756]; embryonic brain development [GO:1990403]; embryonic forelimb morphogenesis [GO:0035115]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; motor learning [GO:0061743]; multicellular organism growth [GO:0035264]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; pigmentation [GO:0043473]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cocaine [GO:0042220]; skeletal system development [GO:0001501]; social behavior [GO:0035176]	SUBCELLULAR LOCATION: Nucleus.
Q05932	reviewed	FOLC_HUMAN	Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase)	FPGS	Homo sapiens (Human)	587	FUNCTION: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269|PubMed:8408018, ECO:0000269|PubMed:8408019, ECO:0000269|PubMed:8408021, ECO:0000269|PubMed:8662720}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at Met-43 of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 1. {ECO:0000305}.	animal organ regeneration [GO:0031100]; cell population proliferation [GO:0008283]; folic acid metabolic process [GO:0046655]; folic acid-containing compound metabolic process [GO:0006760]; glutamate metabolic process [GO:0006536]; liver development [GO:0001889]; nucleobase-containing compound metabolic process [GO:0006139]; one-carbon metabolic process [GO:0006730]; tetrahydrofolylpolyglutamate biosynthetic process [GO:0046901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tetrahydrofolylpolyglutamate synthase activity [GO:0004326]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tetrahydrofolylpolyglutamate synthase activity [GO:0004326]; animal organ regeneration [GO:0031100]; cell population proliferation [GO:0008283]; folic acid metabolic process [GO:0046655]; folic acid-containing compound metabolic process [GO:0006760]; glutamate metabolic process [GO:0006536]; liver development [GO:0001889]; nucleobase-containing compound metabolic process [GO:0006139]; one-carbon metabolic process [GO:0006730]; tetrahydrofolylpolyglutamate biosynthetic process [GO:0046901]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane {ECO:0000269|PubMed:16169100}. Mitochondrion matrix {ECO:0000269|PubMed:16169100, ECO:0000269|PubMed:8408020, ECO:0000269|PubMed:8662720}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:8662720}.
Q05940	reviewed	VMAT2_HUMAN	Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2)	SLC18A2 SVMT VMAT2	Homo sapiens (Human)	514	FUNCTION: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:8643547, PubMed:23363473). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (PubMed:8860238) (By similarity). {ECO:0000250|UniProtKB:Q01827, ECO:0000250|UniProtKB:Q8BRU6, ECO:0000269|PubMed:23363473, ECO:0000269|PubMed:8643547, ECO:0000269|PubMed:8860238}.		aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; chemical synaptic transmission [GO:0007268]; dopamine transport [GO:0015872]; histamine secretion by mast cell [GO:0002553]; histamine uptake [GO:0051615]; locomotory behavior [GO:0007626]; monoamine transport [GO:0015844]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter transport [GO:0006836]; post-embryonic development [GO:0009791]; response to amphetamine [GO:0001975]; response to toxic substance [GO:0009636]; sequestering of neurotransmitter [GO:0042137]; serotonin secretion by mast cell [GO:0002552]; serotonin uptake [GO:0051610]; somato-dendritic dopamine secretion [GO:0099123]	axon [GO:0030424]; centrosome [GO:0005813]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; dendrite [GO:0030425]; dopaminergic synapse [GO:0098691]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	monoamine transmembrane transporter activity [GO:0008504]; monoamine:proton antiporter activity [GO:0015311]; serotonin:sodium:chloride symporter activity [GO:0005335]	axon [GO:0030424]; centrosome [GO:0005813]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; dendrite [GO:0030425]; dopaminergic synapse [GO:0098691]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; monoamine transmembrane transporter activity [GO:0008504]; monoamine:proton antiporter activity [GO:0015311]; serotonin:sodium:chloride symporter activity [GO:0005335]; aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; chemical synaptic transmission [GO:0007268]; dopamine transport [GO:0015872]; histamine secretion by mast cell [GO:0002553]; histamine uptake [GO:0051615]; locomotory behavior [GO:0007626]; monoamine transport [GO:0015844]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter transport [GO:0006836]; post-embryonic development [GO:0009791]; response to amphetamine [GO:0001975]; response to toxic substance [GO:0009636]; sequestering of neurotransmitter [GO:0042137]; serotonin secretion by mast cell [GO:0002552]; serotonin uptake [GO:0051610]; somato-dendritic dopamine secretion [GO:0099123]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q01827}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q01827}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q01827}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q01827}. Note=Sorted to large dense core granules in neuroendocrine cells, presumably at the level of the trans-Golgi network. In neurons it is predominantly detected in somatodendritic tubulovesicular membranes, a distinct population of secretory vesicles that undergo calcium-dependent exocytosis in axons and dendrites upon depolarization. Localized at synaptic vesicles in axons. {ECO:0000250|UniProtKB:Q01827}.
Q05996	reviewed	ZP2_HUMAN	Zona pellucida sperm-binding protein 2 (Zona pellucida glycoprotein 2) (Zp-2) (Zona pellucida protein A) [Cleaved into: Processed zona pellucida sperm-binding protein 2]	ZP2 ZPA	Homo sapiens (Human)	745	FUNCTION: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy (PubMed:29895852). The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (PubMed:29895852). {ECO:0000269|PubMed:29895852}.		binding of sperm to zona pellucida [GO:0007339]; prevention of polyspermy [GO:0060468]	collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]	acrosin binding [GO:0032190]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; structural constituent of egg coat [GO:0035804]	collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; acrosin binding [GO:0032190]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; structural constituent of egg coat [GO:0035804]; binding of sperm to zona pellucida [GO:0007339]; prevention of polyspermy [GO:0060468]	SUBCELLULAR LOCATION: [Processed zona pellucida sperm-binding protein 2]: Zona pellucida {ECO:0000269|PubMed:29895852}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20239}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P20239}.
Q05BQ5	reviewed	MBTD1_HUMAN	MBT domain-containing protein 1	MBTD1	Homo sapiens (Human)	628	FUNCTION: Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:27153538, PubMed:32209463). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively) (PubMed:19841675, PubMed:27153538, PubMed:32209463). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me (PubMed:27153538). Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR) (PubMed:27153538). {ECO:0000269|PubMed:19841675, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; embryonic skeletal system development [GO:0048706]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]	NuA4 histone acetyltransferase complex [GO:0035267]; nucleosome [GO:0000786]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; NuA4 histone acetyltransferase complex binding [GO:0062060]; zinc ion binding [GO:0008270]	NuA4 histone acetyltransferase complex [GO:0035267]; nucleosome [GO:0000786]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; NuA4 histone acetyltransferase complex binding [GO:0062060]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; embryonic skeletal system development [GO:0048706]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:27153538}. Chromosome {ECO:0000269|PubMed:27153538}.
Q05D60	reviewed	DEUP1_HUMAN	Deuterosome assembly protein 1 (Coiled-coil domain-containing protein 67)	DEUP1 CCDC67	Homo sapiens (Human)	604	FUNCTION: Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). {ECO:0000250}.	MISCELLANEOUS: CEP63 and DEUP1 paralogs are both involved in centriole amplification: while CEP63 mediates mother-centriole-dependent centriole duplication, DEUP1 mediates de novo centriole amplification in multiciliated cells.	cell projection organization [GO:0030030]; centriole replication [GO:0007099]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; multi-ciliated epithelial cell differentiation [GO:1903251]	centriole [GO:0005814]; cytoplasm [GO:0005737]; deuterosome [GO:0098536]	identical protein binding [GO:0042802]	centriole [GO:0005814]; cytoplasm [GO:0005737]; deuterosome [GO:0098536]; identical protein binding [GO:0042802]; cell projection organization [GO:0030030]; centriole replication [GO:0007099]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; multi-ciliated epithelial cell differentiation [GO:1903251]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localizes to the deuterosome. {ECO:0000250}.
Q06033	reviewed	ITIH3_HUMAN	Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP)	ITIH3	Homo sapiens (Human)	890	FUNCTION: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.		hyaluronan metabolic process [GO:0030212]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089]	endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; hyaluronan metabolic process [GO:0030212]	SUBCELLULAR LOCATION: Secreted.
Q06055	reviewed	AT5G2_HUMAN	ATP synthase F(0) complex subunit C2, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase membrane subunit c locus 2) (ATP synthase proteolipid P2) (ATP synthase proton-transporting mitochondrial F(0) complex subunit C2) (ATPase protein 9) (ATPase subunit c)	ATP5MC2 ATP5G2 PSEC0033	Homo sapiens (Human)	141	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.	MISCELLANEOUS: There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).	proton motive force-driven ATP synthesis [GO:0015986]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]	lipid binding [GO:0008289]; proton transmembrane transporter activity [GO:0015078]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; lipid binding [GO:0008289]; proton transmembrane transporter activity [GO:0015078]; proton motive force-driven ATP synthesis [GO:0015986]	SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane protein.
Q06124	reviewed	PTN11_HUMAN	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)	PTPN11 PTP2C SHPTP2	Homo sapiens (Human)	593	FUNCTION: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884). {ECO:0000250|UniProtKB:P35235, ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466, ECO:0000269|PubMed:19275884, ECO:0000269|PubMed:26742426, ECO:0000269|PubMed:28074573}.		atrioventricular canal development [GO:0036302]; axonogenesis [GO:0007409]; Bergmann glial cell differentiation [GO:0060020]; brain development [GO:0007420]; cellular response to epidermal growth factor stimulus [GO:0071364]; cerebellar cortex formation [GO:0021697]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage checkpoint signaling [GO:0000077]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB signaling pathway [GO:0038127]; face morphogenesis [GO:0060325]; fibroblast growth factor receptor signaling pathway [GO:0008543]; genitalia development [GO:0048806]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; homeostasis of number of cells within a tissue [GO:0048873]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; inner ear development [GO:0048839]; integrin-mediated signaling pathway [GO:0007229]; intestinal epithelial cell migration [GO:0061582]; megakaryocyte development [GO:0035855]; microvillus organization [GO:0032528]; multicellular organism growth [GO:0035264]; multicellular organismal reproductive process [GO:0048609]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of cortisol secretion [GO:0051463]; negative regulation of growth hormone secretion [GO:0060125]; negative regulation of insulin secretion [GO:0046676]; negative regulation of type I interferon production [GO:0032480]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organ growth [GO:0035265]; peptidyl-tyrosine dephosphorylation [GO:0035335]; platelet formation [GO:0030220]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucose import [GO:0046326]; positive regulation of hormone secretion [GO:0046887]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of ossification [GO:0045778]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of tumor necrosis factor production [GO:0032760]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of protein export from nucleus [GO:0046825]; regulation of protein-containing complex assembly [GO:0043254]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; T cell costimulation [GO:0031295]; triglyceride metabolic process [GO:0006641]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; insulin receptor binding [GO:0005158]; molecular adaptor activity [GO:0060090]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; peptide hormone receptor binding [GO:0051428]; phosphoprotein phosphatase activity [GO:0004721]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor complex adaptor activity [GO:0030159]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; insulin receptor binding [GO:0005158]; molecular adaptor activity [GO:0060090]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; peptide hormone receptor binding [GO:0051428]; phosphoprotein phosphatase activity [GO:0004721]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor complex adaptor activity [GO:0030159]; atrioventricular canal development [GO:0036302]; axonogenesis [GO:0007409]; Bergmann glial cell differentiation [GO:0060020]; brain development [GO:0007420]; cellular response to epidermal growth factor stimulus [GO:0071364]; cerebellar cortex formation [GO:0021697]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage checkpoint signaling [GO:0000077]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB signaling pathway [GO:0038127]; face morphogenesis [GO:0060325]; fibroblast growth factor receptor signaling pathway [GO:0008543]; genitalia development [GO:0048806]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; homeostasis of number of cells within a tissue [GO:0048873]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; inner ear development [GO:0048839]; integrin-mediated signaling pathway [GO:0007229]; intestinal epithelial cell migration [GO:0061582]; megakaryocyte development [GO:0035855]; microvillus organization [GO:0032528]; multicellular organism growth [GO:0035264]; multicellular organismal reproductive process [GO:0048609]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of cortisol secretion [GO:0051463]; negative regulation of growth hormone secretion [GO:0060125]; negative regulation of insulin secretion [GO:0046676]; negative regulation of type I interferon production [GO:0032480]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organ growth [GO:0035265]; peptidyl-tyrosine dephosphorylation [GO:0035335]; platelet formation [GO:0030220]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucose import [GO:0046326]; positive regulation of hormone secretion [GO:0046887]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of ossification [GO:0045778]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of tumor necrosis factor production [GO:0032760]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of protein export from nucleus [GO:0046825]; regulation of protein-containing complex assembly [GO:0043254]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; T cell costimulation [GO:0031295]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26742426}. Nucleus {ECO:0000269|PubMed:26742426}.
Q06136	reviewed	KDSR_HUMAN	3-ketodihydrosphingosine reductase (KDS reductase) (EC 1.1.1.102) (3-dehydrosphinganine reductase) (Follicular variant translocation protein 1) (FVT-1) (Short chain dehydrogenase/reductase family 35C member 1)	KDSR FVT1 SDR35C1	Homo sapiens (Human)	332	FUNCTION: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). {ECO:0000269|PubMed:28575652}.		3-keto-sphinganine metabolic process [GO:0006666]; sphingolipid biosynthetic process [GO:0030148]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; membrane [GO:0016020]	3-dehydrosphinganine reductase activity [GO:0047560]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; membrane [GO:0016020]; 3-dehydrosphinganine reductase activity [GO:0047560]; 3-keto-sphinganine metabolic process [GO:0006666]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15328338}; Multi-pass membrane protein {ECO:0000269|PubMed:15328338}.
Q06141	reviewed	REG3A_HUMAN	Regenerating islet-derived protein 3-alpha (REG-3-alpha) (Hepatointestinal pancreatic protein) (HIP/PAP) (Human proislet peptide) (HIP) (Pancreatitis-associated protein 1) (Regenerating islet-derived protein III-alpha) (Reg III-alpha) [Cleaved into: Regenerating islet-derived protein 3-alpha 16.5 kDa form; Regenerating islet-derived protein 3-alpha 15 kDa form]	REG3A HIP PAP PAP1	Homo sapiens (Human)	175	FUNCTION: [Regenerating islet-derived protein 3-alpha 15 kDa form]: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan (PubMed:16931762). Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore (PubMed:24256734). {ECO:0000269|PubMed:16931762, ECO:0000269|PubMed:24256734}.; FUNCTION: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways (PubMed:22727489, PubMed:19158046, PubMed:34099862, PubMed:27830702). Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway (PubMed:22727489). In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF (PubMed:27830702). In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation (PubMed:19158046). {ECO:0000269|PubMed:19158046, ECO:0000269|PubMed:22727489, ECO:0000269|PubMed:27830702, ECO:0000269|PubMed:34099862}.; FUNCTION: [Regenerating islet-derived protein 3-alpha 16.5 kDa form]: Has bacteriostatic activity. {ECO:0000305|PubMed:24256734}.		acute-phase response [GO:0006953]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell wall disruption in another organism [GO:0044278]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of inflammatory response [GO:0050728]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of keratinocyte differentiation [GO:0045617]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of detection of glucose [GO:2000972]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of wound healing [GO:0090303]; response to peptide hormone [GO:0043434]; response to symbiotic bacterium [GO:0009609]; response to wounding [GO:0009611]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	carbohydrate binding [GO:0030246]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; oligosaccharide binding [GO:0070492]; peptidoglycan binding [GO:0042834]; signaling receptor activity [GO:0038023]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; carbohydrate binding [GO:0030246]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; oligosaccharide binding [GO:0070492]; peptidoglycan binding [GO:0042834]; signaling receptor activity [GO:0038023]; acute-phase response [GO:0006953]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell wall disruption in another organism [GO:0044278]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of inflammatory response [GO:0050728]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of keratinocyte differentiation [GO:0045617]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of detection of glucose [GO:2000972]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of wound healing [GO:0090303]; response to peptide hormone [GO:0043434]; response to symbiotic bacterium [GO:0009609]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1469087}. Note=Found in the apical region of pancreatic acinar cells. {ECO:0000269|PubMed:1469087}.
Q06187	reviewed	BTK_HUMAN	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)	BTK AGMX1 ATK BPK	Homo sapiens (Human)	659	FUNCTION: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}.	MISCELLANEOUS: [Isoform BTK-C]: Produced by alternative promoter usage. Predominant form in many tumor cells where it may function as an anti-apoptotic cell survival factor. {ECO:0000305}.	adaptive immune response [GO:0002250]; apoptotic signaling pathway [GO:0097190]; B cell activation [GO:0042113]; B cell affinity maturation [GO:0002344]; B cell receptor signaling pathway [GO:0050853]; calcium-mediated signaling [GO:0019722]; canonical NF-kappaB signal transduction [GO:0007249]; cell maturation [GO:0048469]; cellular response to interleukin-7 [GO:0098761]; cellular response to molecule of fungal origin [GO:0071226]; cellular response to reactive oxygen species [GO:0034614]; eosinophil homeostasis [GO:1990959]; Fc-epsilon receptor signaling pathway [GO:0038095]; histamine secretion by mast cell [GO:0002553]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; mesoderm development [GO:0007498]; monocyte proliferation [GO:0061516]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of interleukin-10 production [GO:0032693]; neutrophil homeostasis [GO:0001780]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-17A production [GO:0150153]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of phagocytosis [GO:0050766]; positive regulation of synoviocyte proliferation [GO:1901647]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I hypersensitivity [GO:0001812]; positive regulation of type III hypersensitivity [GO:0001805]; protein phosphorylation [GO:0006468]; proteoglycan catabolic process [GO:0030167]; regulation of B cell apoptotic process [GO:0002902]; regulation of B cell cytokine production [GO:0002721]; response to lipopolysaccharide [GO:0032496]; T cell receptor signaling pathway [GO:0050852]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; protein tyrosine kinase activity [GO:0004713]; adaptive immune response [GO:0002250]; apoptotic signaling pathway [GO:0097190]; B cell activation [GO:0042113]; B cell affinity maturation [GO:0002344]; B cell receptor signaling pathway [GO:0050853]; calcium-mediated signaling [GO:0019722]; canonical NF-kappaB signal transduction [GO:0007249]; cell maturation [GO:0048469]; cellular response to interleukin-7 [GO:0098761]; cellular response to molecule of fungal origin [GO:0071226]; cellular response to reactive oxygen species [GO:0034614]; eosinophil homeostasis [GO:1990959]; Fc-epsilon receptor signaling pathway [GO:0038095]; histamine secretion by mast cell [GO:0002553]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; mesoderm development [GO:0007498]; monocyte proliferation [GO:0061516]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of interleukin-10 production [GO:0032693]; neutrophil homeostasis [GO:0001780]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-17A production [GO:0150153]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of phagocytosis [GO:0050766]; positive regulation of synoviocyte proliferation [GO:1901647]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I hypersensitivity [GO:0001812]; positive regulation of type III hypersensitivity [GO:0001805]; protein phosphorylation [GO:0006468]; proteoglycan catabolic process [GO:0030167]; regulation of B cell apoptotic process [GO:0002902]; regulation of B cell cytokine production [GO:0002721]; response to lipopolysaccharide [GO:0032496]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11016936}. Cell membrane {ECO:0000269|PubMed:10196179, ECO:0000269|PubMed:10602036}; Peripheral membrane protein {ECO:0000269|PubMed:10196179, ECO:0000269|PubMed:10602036}. Nucleus {ECO:0000269|PubMed:11016936}. Membrane raft {ECO:0000250|UniProtKB:P35991}. Note=In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1. {ECO:0000303|PubMed:19290921}.
Q06190	reviewed	P2R3A_HUMAN	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B)	PPP2R3A PPP2R3	Homo sapiens (Human)	1150	FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.		eye photoreceptor cell differentiation [GO:0001754]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein catabolic process [GO:0045732]; protein dephosphorylation [GO:0006470]; regulation of cell migration involved in somitogenic axis elongation [GO:0090249]; somatic muscle development [GO:0007525]; somite development [GO:0061053]; Wnt signaling pathway involved in somitogenesis [GO:0090244]	protein phosphatase type 2A complex [GO:0000159]	calcium ion binding [GO:0005509]; protein phosphatase regulator activity [GO:0019888]; protein-macromolecule adaptor activity [GO:0030674]	protein phosphatase type 2A complex [GO:0000159]; calcium ion binding [GO:0005509]; protein phosphatase regulator activity [GO:0019888]; protein-macromolecule adaptor activity [GO:0030674]; eye photoreceptor cell differentiation [GO:0001754]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein catabolic process [GO:0045732]; protein dephosphorylation [GO:0006470]; regulation of cell migration involved in somitogenic axis elongation [GO:0090249]; somatic muscle development [GO:0007525]; somite development [GO:0061053]; Wnt signaling pathway involved in somitogenesis [GO:0090244]	
Q06203	reviewed	PUR1_HUMAN	Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT)	PPAT GPAT	Homo sapiens (Human)	517	FUNCTION: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. {ECO:0000250|UniProtKB:P35433}.		'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleotide biosynthetic process [GO:0006164]	cytosol [GO:0005829]	4 iron, 4 sulfur cluster binding [GO:0051539]; amidophosphoribosyltransferase activity [GO:0004044]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; amidophosphoribosyltransferase activity [GO:0004044]; metal ion binding [GO:0046872]; 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleotide biosynthetic process [GO:0006164]	
Q06210	reviewed	GFPT1_HUMAN	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1)	GFPT1 GFAT GFPT	Homo sapiens (Human)	699	FUNCTION: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). {ECO:0000250|UniProtKB:P47856, ECO:0000269|PubMed:26887390}.		circadian regulation of gene expression [GO:0032922]; energy reserve metabolic process [GO:0006112]; fructose 6-phosphate metabolic process [GO:0006002]; glutamine metabolic process [GO:0006541]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360]; circadian regulation of gene expression [GO:0032922]; energy reserve metabolic process [GO:0006112]; fructose 6-phosphate metabolic process [GO:0006002]; glutamine metabolic process [GO:0006541]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047]	
Q06265	reviewed	EXOS9_HUMAN	Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75)	EXOSC9 PMSCL1	Homo sapiens (Human)	439	FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}.		exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; immune response [GO:0006955]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; positive regulation of cell growth [GO:0030307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5'-RNA exonuclease activity [GO:0000175]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5'-RNA exonuclease activity [GO:0000175]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; immune response [GO:0006955]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; positive regulation of cell growth [GO:0030307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11782436}. Nucleus {ECO:0000269|PubMed:24105744}. Nucleus, nucleolus {ECO:0000269|PubMed:24105744}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24105744}. Note=Colocalizes with SETX in nuclear foci upon induction of transcription-related DNA damage at the S phase (PubMed:24105744). {ECO:0000269|PubMed:24105744}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleolus.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, nucleolus.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Note=Excluded from the nucleolus.
Q06278	reviewed	AOXA_HUMAN	Aldehyde oxidase (EC 1.2.3.1) (Aldehyde oxidase 1) (Azaheterocycle hydroxylase) (EC 1.17.3.-)	AOX1 AO	Homo sapiens (Human)	1338	FUNCTION: Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. {ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:22031625, ECO:0000269|PubMed:22279051, ECO:0000269|PubMed:22522748, ECO:0000269|PubMed:22996261, ECO:0000269|PubMed:23857892, ECO:0000269|PubMed:26322824, ECO:0000269|PubMed:7786031, ECO:0000269|PubMed:9224775}.	MISCELLANEOUS: AOX genes evolved from a xanthine oxidoreductase ancestral precursor via a series of gene duplication and suppression/deletion events. Different animal species contain a different complement of AOX genes encoding an equivalent number of AOX isoenzymes. In mammals, the two extremes are represented by certain rodents such as mice and rats, which are endowed with 4 AOX genes, and by humans, whose genome is characterized by a single active gene (PubMed:22335465). {ECO:0000305|PubMed:22335465}.	lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	2 iron, 2 sulfur cluster binding [GO:0051537]; aldehyde oxidase activity [GO:0004031]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; NAD binding [GO:0051287]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 2 iron, 2 sulfur cluster binding [GO:0051537]; aldehyde oxidase activity [GO:0004031]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; NAD binding [GO:0051287]; protein homodimerization activity [GO:0042803]; lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18671973, ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:23857892}.
Q06323	reviewed	PSME1_HUMAN	Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha)	PSME1 IFI5111	Homo sapiens (Human)	249	FUNCTION: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.		antigen processing and presentation of exogenous antigen [GO:0019884]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]	endopeptidase activator activity [GO:0061133]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]; endopeptidase activator activity [GO:0061133]; antigen processing and presentation of exogenous antigen [GO:0019884]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136]	
Q06330	reviewed	SUH_HUMAN	Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30)	RBPJ IGKJRB IGKJRB1 RBPJK RBPSUH	Homo sapiens (Human)	500	FUNCTION: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). {ECO:0000250|UniProtKB:P31266, ECO:0000269|PubMed:21991380, ECO:0000269|PubMed:23303788}.		angiogenesis [GO:0001525]; aortic valve development [GO:0003176]; arterial endothelial cell fate commitment [GO:0060844]; atrioventricular canal development [GO:0036302]; auditory receptor cell fate commitment [GO:0009912]; B cell differentiation [GO:0030183]; blood vessel endothelial cell fate specification [GO:0097101]; blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell myoblast differentiation [GO:0060379]; club cell differentiation [GO:0060486]; defense response to bacterium [GO:0042742]; dorsal aorta morphogenesis [GO:0035912]; endocardium morphogenesis [GO:0003160]; epidermal cell fate specification [GO:0009957]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; hair follicle maturation [GO:0048820]; humoral immune response [GO:0006959]; inflammatory response to antigenic stimulus [GO:0002437]; keratinocyte differentiation [GO:0030216]; labyrinthine layer blood vessel development [GO:0060716]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ossification [GO:0030279]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; pituitary gland development [GO:0021983]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [GO:1901297]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of ephrin receptor signaling pathway [GO:1901189]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERBB signaling pathway [GO:1901186]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription of Notch receptor target [GO:0007221]; pulmonary valve development [GO:0003177]; regulation of reproductive process [GO:2000241]; regulation of timing of cell differentiation [GO:0048505]; regulation of transcription by RNA polymerase II [GO:0006357]; sebaceous gland development [GO:0048733]; secondary heart field specification [GO:0003139]; somatic stem cell population maintenance [GO:0035019]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; angiogenesis [GO:0001525]; aortic valve development [GO:0003176]; arterial endothelial cell fate commitment [GO:0060844]; atrioventricular canal development [GO:0036302]; auditory receptor cell fate commitment [GO:0009912]; B cell differentiation [GO:0030183]; blood vessel endothelial cell fate specification [GO:0097101]; blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell myoblast differentiation [GO:0060379]; club cell differentiation [GO:0060486]; defense response to bacterium [GO:0042742]; dorsal aorta morphogenesis [GO:0035912]; endocardium morphogenesis [GO:0003160]; epidermal cell fate specification [GO:0009957]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; hair follicle maturation [GO:0048820]; humoral immune response [GO:0006959]; inflammatory response to antigenic stimulus [GO:0002437]; keratinocyte differentiation [GO:0030216]; labyrinthine layer blood vessel development [GO:0060716]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ossification [GO:0030279]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; pituitary gland development [GO:0021983]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [GO:1901297]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of ephrin receptor signaling pathway [GO:1901189]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERBB signaling pathway [GO:1901186]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription of Notch receptor target [GO:0007221]; pulmonary valve development [GO:0003177]; regulation of reproductive process [GO:2000241]; regulation of timing of cell differentiation [GO:0048505]; regulation of transcription by RNA polymerase II [GO:0006357]; sebaceous gland development [GO:0048733]; secondary heart field specification [GO:0003139]; somatic stem cell population maintenance [GO:0035019]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway.
Q06413	reviewed	MEF2C_HUMAN	Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C)	MEF2C	Homo sapiens (Human)	473	FUNCTION: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}.		apoptotic process [GO:0006915]; B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cardiac ventricle formation [GO:0003211]; cell differentiation [GO:0030154]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to calcium ion [GO:0071277]; cellular response to fluid shear stress [GO:0071498]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to trichostatin A [GO:0035984]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; excitatory postsynaptic potential [GO:0060079]; germinal center formation [GO:0002467]; glomerulus morphogenesis [GO:0072102]; heart development [GO:0007507]; heart looping [GO:0001947]; humoral immune response [GO:0006959]; learning or memory [GO:0007611]; MAPK cascade [GO:0000165]; melanocyte differentiation [GO:0030318]; muscle cell fate determination [GO:0007521]; muscle organ development [GO:0007517]; myotube differentiation [GO:0014902]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; nephron tubule epithelial cell differentiation [GO:0072160]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary heart field specification [GO:0003138]; regulation of AMPA receptor activity [GO:2000311]; regulation of dendritic spine development [GO:0060998]; regulation of DNA-templated transcription [GO:0006355]; regulation of germinal center formation [GO:0002634]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of neuron apoptotic process [GO:0043523]; regulation of neurotransmitter secretion [GO:0046928]; regulation of NMDA receptor activity [GO:2000310]; regulation of synapse assembly [GO:0051963]; regulation of synaptic activity [GO:0060025]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, glutamatergic [GO:0051966]; renal tubule morphogenesis [GO:0061333]; response to ischemia [GO:0002931]; secondary heart field specification [GO:0003139]; sinoatrial valve morphogenesis [GO:0003185]; skeletal muscle tissue development [GO:0007519]; smooth muscle cell differentiation [GO:0051145]; ventricular cardiac muscle cell differentiation [GO:0055012]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; sarcoplasm [GO:0016528]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; sarcoplasm [GO:0016528]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; apoptotic process [GO:0006915]; B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cardiac ventricle formation [GO:0003211]; cell differentiation [GO:0030154]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to calcium ion [GO:0071277]; cellular response to fluid shear stress [GO:0071498]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to trichostatin A [GO:0035984]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; excitatory postsynaptic potential [GO:0060079]; germinal center formation [GO:0002467]; glomerulus morphogenesis [GO:0072102]; heart development [GO:0007507]; heart looping [GO:0001947]; humoral immune response [GO:0006959]; learning or memory [GO:0007611]; MAPK cascade [GO:0000165]; melanocyte differentiation [GO:0030318]; muscle cell fate determination [GO:0007521]; muscle organ development [GO:0007517]; myotube differentiation [GO:0014902]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; nephron tubule epithelial cell differentiation [GO:0072160]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary heart field specification [GO:0003138]; regulation of AMPA receptor activity [GO:2000311]; regulation of dendritic spine development [GO:0060998]; regulation of DNA-templated transcription [GO:0006355]; regulation of germinal center formation [GO:0002634]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of neuron apoptotic process [GO:0043523]; regulation of neurotransmitter secretion [GO:0046928]; regulation of NMDA receptor activity [GO:2000310]; regulation of synapse assembly [GO:0051963]; regulation of synaptic activity [GO:0060025]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, glutamatergic [GO:0051966]; renal tubule morphogenesis [GO:0061333]; response to ischemia [GO:0002931]; secondary heart field specification [GO:0003139]; sinoatrial valve morphogenesis [GO:0003185]; skeletal muscle tissue development [GO:0007519]; smooth muscle cell differentiation [GO:0051145]; ventricular cardiac muscle cell differentiation [GO:0055012]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A0A096MJY4}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A0A096MJY4}.
Q06416	reviewed	P5F1B_HUMAN	Putative POU domain, class 5, transcription factor 1B (Oct4-pg1) (Octamer-binding protein 3-like) (Octamer-binding transcription factor 3-like)	POU5F1B OCT4PG1 OTF3C OTF3P1 POU5F1P1 POU5FLC20 POU5FLC8	Homo sapiens (Human)	359	FUNCTION: Shows weak transcriptional activator activity. {ECO:0000269|PubMed:18949397}.		regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00530, ECO:0000269|PubMed:18949397}.
Q06418	reviewed	TYRO3_HUMAN	Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)	TYRO3 BYK DTK RSE SKY TIF	Homo sapiens (Human)	890	FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:20546121}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688}.		apoptotic cell clearance [GO:0043277]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; establishment of localization in cell [GO:0051649]; forebrain cell migration [GO:0021885]; natural killer cell differentiation [GO:0001779]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of lymphocyte activation [GO:0051250]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron cellular homeostasis [GO:0070050]; neuron migration [GO:0001764]; neuropeptide signaling pathway [GO:0007218]; ovulation cycle [GO:0042698]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of viral life cycle [GO:1903902]; protein autophosphorylation [GO:0046777]; secretion by cell [GO:0032940]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vagina development [GO:0060068]	cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; virus receptor activity [GO:0001618]; apoptotic cell clearance [GO:0043277]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; establishment of localization in cell [GO:0051649]; forebrain cell migration [GO:0021885]; natural killer cell differentiation [GO:0001779]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of lymphocyte activation [GO:0051250]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron cellular homeostasis [GO:0070050]; neuron migration [GO:0001764]; neuropeptide signaling pathway [GO:0007218]; ovulation cycle [GO:0042698]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of viral life cycle [GO:1903902]; protein autophosphorylation [GO:0046777]; secretion by cell [GO:0032940]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vagina development [GO:0060068]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q06432	reviewed	CCG1_HUMAN	Voltage-dependent calcium channel gamma-1 subunit (Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma)	CACNG1 CACNLG	Homo sapiens (Human)	222	FUNCTION: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. {ECO:0000250|UniProtKB:P19518}.		calcium ion transmembrane transport [GO:0070588]; establishment of localization in cell [GO:0051649]; positive regulation of muscle contraction [GO:0045933]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; sarcoplasmic reticulum calcium ion transport [GO:0070296]	L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]	calcium channel regulator activity [GO:0005246]; voltage-gated calcium channel activity [GO:0005245]	L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; calcium channel regulator activity [GO:0005246]; voltage-gated calcium channel activity [GO:0005245]; calcium ion transmembrane transport [GO:0070588]; establishment of localization in cell [GO:0051649]; positive regulation of muscle contraction [GO:0045933]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; sarcoplasmic reticulum calcium ion transport [GO:0070296]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P19518}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19518}.
Q06455	reviewed	MTG8_HUMAN	Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2)	RUNX1T1 AML1T1 CBFA2T1 CDR ETO MTG8 ZMYND2	Homo sapiens (Human)	604	FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.		DNA-templated transcription [GO:0006351]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]	nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; DNA-templated transcription [GO:0006351]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00440, ECO:0000269|PubMed:10973986}. Note=Colocalizes with ATN1 in discrete nuclear dots.
Q06481	reviewed	APLP2_HUMAN	Amyloid beta precursor like protein 2 (APPH) (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II)	APLP2 APPL2	Homo sapiens (Human)	763	FUNCTION: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). {ECO:0000250, ECO:0000269|PubMed:8307156}.		axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; G protein-coupled receptor signaling pathway [GO:0007186]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	DNA binding [GO:0003677]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; serine-type endopeptidase inhibitor activity [GO:0004867]; transition metal ion binding [GO:0046914]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; DNA binding [GO:0003677]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; serine-type endopeptidase inhibitor activity [GO:0004867]; transition metal ion binding [GO:0046914]; axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus {ECO:0000305}.
Q06495	reviewed	NPT2A_HUMAN	Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-3) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1)	SLC34A1 NPT2 SLC17A2	Homo sapiens (Human)	639	FUNCTION: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:26047794, PubMed:8327470, PubMed:12324554, PubMed:20335586). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity). {ECO:0000250|UniProtKB:Q06496, ECO:0000269|PubMed:12324554, ECO:0000269|PubMed:20335586, ECO:0000269|PubMed:26047794, ECO:0000269|PubMed:8327470}.		arsenate ion transmembrane transport [GO:1901684]; cellular response to metal ion [GO:0071248]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to phosphate starvation [GO:0016036]; cellular response to staurosporine [GO:0072734]; dentinogenesis [GO:0097187]; gentamycin metabolic process [GO:1901128]; glycoprotein metabolic process [GO:0009100]; indole metabolic process [GO:0042431]; intracellular phosphate ion homeostasis [GO:0030643]; kidney development [GO:0001822]; ossification [GO:0001503]; phosphate ion homeostasis [GO:0055062]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; positive regulation of membrane potential [GO:0045838]; positive regulation of phosphate transmembrane transport [GO:2000187]; positive regulation of sodium-dependent phosphate transport [GO:2000120]; protein metabolic process [GO:0019538]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to growth hormone [GO:0060416]; response to lead ion [GO:0010288]; response to magnesium ion [GO:0032026]; response to mercury ion [GO:0046689]; response to potassium ion [GO:0035864]; response to thyroid hormone [GO:0097066]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; sodium ion import across plasma membrane [GO:0098719]; sodium-dependent phosphate transport [GO:0044341]; tricarboxylic acid metabolic process [GO:0072350]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cytosol [GO:0005829]; endosome [GO:0005768]; mitotic spindle [GO:0072686]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; sodium:phosphate symporter activity [GO:0005436]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cytosol [GO:0005829]; endosome [GO:0005768]; mitotic spindle [GO:0072686]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; sodium:phosphate symporter activity [GO:0005436]; arsenate ion transmembrane transport [GO:1901684]; cellular response to metal ion [GO:0071248]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to phosphate starvation [GO:0016036]; cellular response to staurosporine [GO:0072734]; dentinogenesis [GO:0097187]; gentamycin metabolic process [GO:1901128]; glycoprotein metabolic process [GO:0009100]; indole metabolic process [GO:0042431]; intracellular phosphate ion homeostasis [GO:0030643]; kidney development [GO:0001822]; ossification [GO:0001503]; phosphate ion homeostasis [GO:0055062]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; positive regulation of membrane potential [GO:0045838]; positive regulation of phosphate transmembrane transport [GO:2000187]; positive regulation of sodium-dependent phosphate transport [GO:2000120]; protein metabolic process [GO:0019538]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to growth hormone [GO:0060416]; response to lead ion [GO:0010288]; response to magnesium ion [GO:0032026]; response to mercury ion [GO:0046689]; response to potassium ion [GO:0035864]; response to thyroid hormone [GO:0097066]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; sodium ion import across plasma membrane [GO:0098719]; sodium-dependent phosphate transport [GO:0044341]; tricarboxylic acid metabolic process [GO:0072350]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:26047794}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:20335586}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of the proximal tubules. Internalized from the cell surface upon PTH stimulation. {ECO:0000250|UniProtKB:Q06496, ECO:0000250|UniProtKB:Q60825}.
Q06520	reviewed	ST2A1_HUMAN	Sulfotransferase 2A1 (ST2A1) (EC 2.8.2.2) (Bile salt sulfotransferase) (EC 2.8.2.14) (Dehydroepiandrosterone sulfotransferase) (DHEA-ST) (DHEA-ST8) (Hydroxysteroid Sulfotransferase) (HST) (ST2) (SULT2A3)	SULT2A1 HST STD	Homo sapiens (Human)	285	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:7678732, PubMed:2268288, PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:21187059, PubMed:29671343, PubMed:7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed:21187059, PubMed:19589875, PubMed:14573603). Plays a key role in bile acid metabolism (PubMed:2268288). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity). {ECO:0000250|UniProtKB:P15709, ECO:0000269|PubMed:14573603, ECO:0000269|PubMed:18042734, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:21187059, ECO:0000269|PubMed:2268288, ECO:0000269|PubMed:29671343, ECO:0000269|PubMed:7678732, ECO:0000269|PubMed:7854148}.		3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; bile acid catabolic process [GO:0030573]; cholesterol metabolic process [GO:0008203]; ethanol catabolic process [GO:0006068]; lipid catabolic process [GO:0016042]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; alcohol sulfotransferase activity [GO:0004027]; bile-salt sulfotransferase activity [GO:0047704]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; alcohol sulfotransferase activity [GO:0004027]; bile-salt sulfotransferase activity [GO:0047704]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; bile acid catabolic process [GO:0030573]; cholesterol metabolic process [GO:0008203]; ethanol catabolic process [GO:0006068]; lipid catabolic process [GO:0016042]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:2268288}.
Q06546	reviewed	GABPA_HUMAN	GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60)	GABPA E4TF1A	Homo sapiens (Human)	454	FUNCTION: Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). {ECO:0000269|PubMed:22306510}.; FUNCTION: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene.		blastocyst formation [GO:0001825]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; blastocyst formation [GO:0001825]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q06547	reviewed	GABP1_HUMAN	GA-binding protein subunit beta-1 (GABP subunit beta-1) (GABPB-1) (GABP subunit beta-2) (GABPB-2) (Nuclear respiratory factor 2) (Transcription factor E4TF1-47) (Transcription factor E4TF1-53)	GABPB1 E4TF1B GABPB GABPB2	Homo sapiens (Human)	395	FUNCTION: Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:8441384, PubMed:10675337, PubMed:8816484). Acts as a a master regulator of nuclear-encoded mitochondrial genes (By similarity). {ECO:0000250|UniProtKB:Q00420, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:8441384, ECO:0000269|PubMed:8816484}.; FUNCTION: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene. {ECO:0000269|PubMed:8441384}.		mitochondrion organization [GO:0007005]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription cis-regulatory region binding [GO:0000976]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription cis-regulatory region binding [GO:0000976]; mitochondrion organization [GO:0007005]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:7799916, ECO:0000305|PubMed:8441384}.
Q06587	reviewed	RING1_HUMAN	E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)	RING1 RING1A RNF1	Homo sapiens (Human)	406	FUNCTION: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}.	MISCELLANEOUS: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.	anterior/posterior pattern specification [GO:0009952]; camera-type eye morphogenesis [GO:0048593]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]; ubiquitin ligase complex [GO:0000151]	chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activator activity [GO:0097027]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]; ubiquitin ligase complex [GO:0000151]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activator activity [GO:0097027]; anterior/posterior pattern specification [GO:0009952]; camera-type eye morphogenesis [GO:0048593]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530}. Nucleus speckle {ECO:0000269|PubMed:21282530}.
Q06609	reviewed	RAD51_HUMAN	DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A)	RAD51 RAD51A RECA	Homo sapiens (Human)	339	FUNCTION: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:18417535, PubMed:20348101, PubMed:12205100, PubMed:20231364, PubMed:23754376, PubMed:23509288, PubMed:28575658, PubMed:26681308). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:18417535, PubMed:20348101, PubMed:12205100, PubMed:20231364, PubMed:23754376, PubMed:23509288, PubMed:28575658, PubMed:26681308). Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template (PubMed:18417535, PubMed:20348101, PubMed:12205100, PubMed:20231364, PubMed:23754376, PubMed:23509288, PubMed:28575658, PubMed:26681308). Recruited to resolve stalled replication forks during replication stress (PubMed:27797818, PubMed:31844045). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR (PubMed:24141787, PubMed:12442171). Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 (PubMed:20413593). Also involved in interstrand cross-link repair (PubMed:26253028). {ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:12442171, ECO:0000269|PubMed:18417535, ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20413593, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:26253028, ECO:0000269|PubMed:26681308, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:28575658, ECO:0000269|PubMed:31844045}.	MISCELLANEOUS: [Isoform 3]: Mutagenesis of Arg-264 to Ala inhibits nuclear localization. Mutagenesis of Lys-264 to Gln inhibits nuclear localization. Deletion of 254-Arg-Lys-255 inhibits nuclear localization. {ECO:0000269|PubMed:18417535}.	cellular response to camptothecin [GO:0072757]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response [GO:0006974]; DNA recombinase assembly [GO:0000730]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair involved in meiotic recombination [GO:1990918]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; meiotic cell cycle [GO:0051321]; mitotic recombination [GO:0006312]; mitotic recombination-dependent replication fork processing [GO:1990426]; positive regulation of DNA ligation [GO:0051106]; reciprocal meiotic recombination [GO:0007131]; regulation of DNA damage checkpoint [GO:2000001]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of protein phosphorylation [GO:0001932]; replication fork processing [GO:0031297]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; strand invasion [GO:0042148]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomere lengthening [GO:0010833]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; microtubule organizing center [GO:0005815]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear chromosome [GO:0000228]; nuclear ubiquitin ligase complex [GO:0000152]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; presynaptic intermediate filament cytoskeleton [GO:0099182]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; chromatin binding [GO:0003682]; DNA polymerase binding [GO:0070182]; DNA strand exchange activity [GO:0000150]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; microtubule organizing center [GO:0005815]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear chromosome [GO:0000228]; nuclear ubiquitin ligase complex [GO:0000152]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; presynaptic intermediate filament cytoskeleton [GO:0099182]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; chromatin binding [GO:0003682]; DNA polymerase binding [GO:0070182]; DNA strand exchange activity [GO:0000150]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]; cellular response to camptothecin [GO:0072757]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response [GO:0006974]; DNA recombinase assembly [GO:0000730]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair involved in meiotic recombination [GO:1990918]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; meiotic cell cycle [GO:0051321]; mitotic recombination [GO:0006312]; mitotic recombination-dependent replication fork processing [GO:1990426]; positive regulation of DNA ligation [GO:0051106]; reciprocal meiotic recombination [GO:0007131]; regulation of DNA damage checkpoint [GO:2000001]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of protein phosphorylation [GO:0001932]; replication fork processing [GO:0031297]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; strand invasion [GO:0042148]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomere lengthening [GO:0010833]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12442171, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:18417535, ECO:0000269|PubMed:19783859, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:26681308, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:9192668}. Cytoplasm {ECO:0000269|PubMed:16215984, ECO:0000269|PubMed:26681308}. Cytoplasm, perinuclear region. Mitochondrion matrix {ECO:0000269|PubMed:20413593}. Chromosome {ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:31844045}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage (PubMed:20154705). DNA damage induces an increase in nuclear levels (PubMed:20154705). Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment (PubMed:23754376). Accumulated at sites of DNA damage in a SPIDR-dependent manner (PubMed:23509288). Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner (PubMed:23401855). Colocalizes with ERCC5/XPG to nuclear foci in S phase (PubMed:26833090). Recruited to stalled replication forks during replication stress by the TONSL-MMS22L complex, as well as ATAD5 and WDR48 in an ATR-dependent manner (PubMed:27797818, PubMed:31844045). {ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:31844045}.
Q06643	reviewed	TNFC_HUMAN	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3)	LTB TNFC TNFSF3	Homo sapiens (Human)	244	FUNCTION: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.		cell-cell signaling [GO:0007267]; gene expression [GO:0010467]; immune response [GO:0006955]; lymph node development [GO:0048535]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-12 production [GO:0032735]; signal transduction [GO:0007165]; skin development [GO:0043588]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; cell-cell signaling [GO:0007267]; gene expression [GO:0010467]; immune response [GO:0006955]; lymph node development [GO:0048535]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-12 production [GO:0032735]; signal transduction [GO:0007165]; skin development [GO:0043588]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q06710	reviewed	PAX8_HUMAN	Paired box protein Pax-8	PAX8	Homo sapiens (Human)	450	FUNCTION: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.		anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; branching involved in ureteric bud morphogenesis [GO:0001658]; cellular response to gonadotropin stimulus [GO:0071371]; central nervous system development [GO:0007417]; DNA-templated transcription [GO:0006351]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesonephros development [GO:0001823]; metanephric comma-shaped body morphogenesis [GO:0072278]; metanephric distal convoluted tubule development [GO:0072221]; metanephric epithelium development [GO:0072207]; metanephric nephron tubule formation [GO:0072289]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of apoptotic process involved in metanephric collecting duct development [GO:1900215]; negative regulation of apoptotic process involved in metanephric nephron tubule development [GO:1900218]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis [GO:0072305]; negative regulation of mesenchymal cell apoptotic process involved in metanephros development [GO:1900212]; otic vesicle development [GO:0071599]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of metanephric DCT cell differentiation [GO:2000594]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephric field specification [GO:0039003]; pronephros development [GO:0048793]; regulation of apoptotic process [GO:0042981]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of thyroid-stimulating hormone secretion [GO:2000612]; regulation of transcription by RNA polymerase II [GO:0006357]; sulfur compound metabolic process [GO:0006790]; thyroid gland development [GO:0030878]; urogenital system development [GO:0001655]; ventricular septum development [GO:0003281]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; thyroid-stimulating hormone receptor activity [GO:0004996]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; thyroid-stimulating hormone receptor activity [GO:0004996]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; branching involved in ureteric bud morphogenesis [GO:0001658]; cellular response to gonadotropin stimulus [GO:0071371]; central nervous system development [GO:0007417]; DNA-templated transcription [GO:0006351]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesonephros development [GO:0001823]; metanephric comma-shaped body morphogenesis [GO:0072278]; metanephric distal convoluted tubule development [GO:0072221]; metanephric epithelium development [GO:0072207]; metanephric nephron tubule formation [GO:0072289]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of apoptotic process involved in metanephric collecting duct development [GO:1900215]; negative regulation of apoptotic process involved in metanephric nephron tubule development [GO:1900218]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis [GO:0072305]; negative regulation of mesenchymal cell apoptotic process involved in metanephros development [GO:1900212]; otic vesicle development [GO:0071599]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of metanephric DCT cell differentiation [GO:2000594]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephric field specification [GO:0039003]; pronephros development [GO:0048793]; regulation of apoptotic process [GO:0042981]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of thyroid-stimulating hormone secretion [GO:2000612]; regulation of transcription by RNA polymerase II [GO:0006357]; sulfur compound metabolic process [GO:0006790]; thyroid gland development [GO:0030878]; urogenital system development [GO:0001655]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Nucleus.
Q06730	reviewed	ZN33A_HUMAN	Zinc finger protein 33A (Zinc finger and ZAK-associated protein with KRAB domain) (ZZaPK) (Zinc finger protein 11A) (Zinc finger protein KOX31)	ZNF33A KIAA0065 KOX31 ZNF11 ZNF11A ZNF33	Homo sapiens (Human)	810	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q06787	reviewed	FMR1_HUMAN	Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1)	FMR1	Homo sapiens (Human)	632	FUNCTION: Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs (PubMed:12417522, PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:12417522, PubMed:30765518, PubMed:31439799). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with CAPRIN1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). Acts as a repressor of mRNA translation in synaptic regions by mediating formation of neuronal ribonucleoprotein granules and promoting recruitmtent of EIF4EBP2 (PubMed:30765518). Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postsynaptic dendritic spines (PubMed:11532944, PubMed:11157796, PubMed:12594214, PubMed:23235829). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (By similarity). Represses mRNA translation by stalling ribosomal translocation during elongation (By similarity). Reports are contradictory with regards to its ability to mediate translation inhibition of MBP mRNA in oligodendrocytes (PubMed:23891804). Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2 (PubMed:14703574, PubMed:17057366, PubMed:25464849). Facilitates the assembly of miRNAs on specific target mRNAs (PubMed:17057366). Also plays a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (PubMed:19097999, PubMed:19166269). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (By similarity). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions (PubMed:7692601, PubMed:11719189, PubMed:11157796, PubMed:12594214, PubMed:17417632, PubMed:23235829, PubMed:24448548). Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR (PubMed:23235829). Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets (PubMed:11719189, PubMed:18579868, PubMed:25464849, PubMed:25692235). Binds to G-quadruplex structures in the 3'-UTR of its own mRNA (PubMed:7692601, PubMed:11532944, PubMed:12594214, PubMed:15282548, PubMed:18653529). Binds also to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes (PubMed:15805463). Binds mRNAs containing U-rich target sequences (PubMed:12927206). Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (PubMed:19166269). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (By similarity). Plays a role in mRNA nuclear export (PubMed:31753916). Specifically recognizes and binds a subset of N6-methyladenosine (m6A)-containing mRNAs, promoting their nuclear export in a XPO1/CRM1-dependent manner (PubMed:31753916). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (By similarity). Binds to a subset of miRNAs in the brain (PubMed:14703574, PubMed:17057366). May associate with nascent transcripts in a nuclear protein NXF1-dependent manner (PubMed:18936162). In vitro, binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:7688265, PubMed:7781595, PubMed:12950170, PubMed:15381419, PubMed:8156595). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (PubMed:20512134). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (By similarity). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteasomal degradation (By similarity). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (By similarity). Recently, has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons (PubMed:25561520). Finally, FMR1 may be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AX/H2A.x and BRCA1 phosphorylations (PubMed:24813610). {ECO:0000250|UniProtKB:P35922, ECO:0000250|UniProtKB:Q80WE1, ECO:0000269|PubMed:11157796, ECO:0000269|PubMed:11532944, ECO:0000269|PubMed:11719189, ECO:0000269|PubMed:12417522, ECO:0000269|PubMed:12594214, ECO:0000269|PubMed:12927206, ECO:0000269|PubMed:12950170, ECO:0000269|PubMed:14703574, ECO:0000269|PubMed:15282548, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15805463, ECO:0000269|PubMed:16631377, ECO:0000269|PubMed:17057366, ECO:0000269|PubMed:17417632, ECO:0000269|PubMed:18579868, ECO:0000269|PubMed:18653529, ECO:0000269|PubMed:18936162, ECO:0000269|PubMed:19097999, ECO:0000269|PubMed:19166269, ECO:0000269|PubMed:20512134, ECO:0000269|PubMed:23235829, ECO:0000269|PubMed:23891804, ECO:0000269|PubMed:24448548, ECO:0000269|PubMed:24813610, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:25561520, ECO:0000269|PubMed:25692235, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:31753916, ECO:0000269|PubMed:7688265, ECO:0000269|PubMed:7692601, ECO:0000269|PubMed:7781595, ECO:0000269|PubMed:8156595}.; FUNCTION: [Isoform 10]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: [Isoform 6]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: (Microbial infection) Acts as a positive regulator of influenza A virus (IAV) replication. Required for the assembly and nuclear export of the viral ribonucleoprotein (vRNP) components. {ECO:0000269|PubMed:24514761}.	MISCELLANEOUS: The mechanism of the severe phenotype in the Asn-304 patient lies in the sequestration of bound mRNAs in nontranslatable mRNP particles. In the absence of FMRP, these same mRNAs may be partially translated via alternate mRNPs, although perhaps abnormally localized or regulated, resulting in typical fragile X syndrome. Asn-304 mutation maps to a position within the second KH domain of FMRP that is critical for stabilizing sequence-specific RNA-protein interactions. Asn-304 mutation abrogates the association of the FMRP KH 2 domain with its target, kissing complex RNA.	cellular response to virus [GO:0098586]; DNA repair [GO:0006281]; glutamate receptor signaling pathway [GO:0007215]; modulation by host of viral RNA genome replication [GO:0044830]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of mRNA catabolic process [GO:1902373]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; nervous system development [GO:0007399]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular transport of viral material [GO:1901254]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of mRNA binding [GO:1902416]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of dendritic spine development [GO:0060998]; regulation of filopodium assembly [GO:0051489]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of mRNA stability [GO:0043488]; regulation of neuronal action potential [GO:0098908]; regulation of neurotransmitter secretion [GO:0046928]; regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA splicing [GO:0008380]; stress granule assembly [GO:0034063]	axon [GO:0030424]; axon terminus [GO:0043679]; Cajal body [GO:0015030]; cell projection [GO:0042995]; chromocenter [GO:0010369]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic filopodium [GO:1902737]; dendritic spine [GO:0043197]; dendritic spine neck [GO:0044326]; filopodium tip [GO:0032433]; glial cell projection [GO:0097386]; growth cone [GO:0030426]; growth cone filopodium [GO:1990812]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; messenger ribonucleoprotein complex [GO:1990124]; mRNA cap binding complex [GO:0005845]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal ribonucleoprotein granule [GO:0071598]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]	chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; G-quadruplex RNA binding [GO:0002151]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; microtubule binding [GO:0008017]; miRNA binding [GO:0035198]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; poly(A) binding [GO:0008143]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; RNA strand annealing activity [GO:0033592]; sequence-specific mRNA binding [GO:1990825]; signaling adaptor activity [GO:0035591]; siRNA binding [GO:0035197]; translation initiation factor binding [GO:0031369]; translation regulator activity [GO:0045182]; translation repressor activity [GO:0030371]; transmembrane transporter binding [GO:0044325]	axon [GO:0030424]; axon terminus [GO:0043679]; Cajal body [GO:0015030]; cell projection [GO:0042995]; chromocenter [GO:0010369]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic filopodium [GO:1902737]; dendritic spine [GO:0043197]; dendritic spine neck [GO:0044326]; filopodium tip [GO:0032433]; glial cell projection [GO:0097386]; growth cone [GO:0030426]; growth cone filopodium [GO:1990812]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; messenger ribonucleoprotein complex [GO:1990124]; mRNA cap binding complex [GO:0005845]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal ribonucleoprotein granule [GO:0071598]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]; chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; G-quadruplex RNA binding [GO:0002151]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; microtubule binding [GO:0008017]; miRNA binding [GO:0035198]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; poly(A) binding [GO:0008143]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; RNA strand annealing activity [GO:0033592]; sequence-specific mRNA binding [GO:1990825]; signaling adaptor activity [GO:0035591]; siRNA binding [GO:0035197]; translation initiation factor binding [GO:0031369]; translation regulator activity [GO:0045182]; translation repressor activity [GO:0030371]; transmembrane transporter binding [GO:0044325]; cellular response to virus [GO:0098586]; DNA repair [GO:0006281]; glutamate receptor signaling pathway [GO:0007215]; modulation by host of viral RNA genome replication [GO:0044830]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of mRNA catabolic process [GO:1902373]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; nervous system development [GO:0007399]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular transport of viral material [GO:1901254]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of mRNA binding [GO:1902416]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of dendritic spine development [GO:0060998]; regulation of filopodium assembly [GO:0051489]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of mRNA stability [GO:0043488]; regulation of neuronal action potential [GO:0098908]; regulation of neurotransmitter secretion [GO:0046928]; regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA splicing [GO:0008380]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:12417734, ECO:0000269|PubMed:14532325, ECO:0000269|PubMed:15380484, ECO:0000269|PubMed:16636078, ECO:0000269|PubMed:18093976, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:9659908}. Cytoplasm, Stress granule {ECO:0000269|PubMed:12417522, ECO:0000269|PubMed:16636078, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:18664458}. Cytoplasm {ECO:0000269|PubMed:10196376, ECO:0000269|PubMed:12837692, ECO:0000269|PubMed:18664458, ECO:0000269|PubMed:18936162, ECO:0000269|PubMed:7781595, ECO:0000269|PubMed:8401578, ECO:0000269|PubMed:8515814, ECO:0000269|PubMed:9259278}. Perikaryon {ECO:0000269|PubMed:12417734, ECO:0000269|PubMed:15380484, ECO:0000269|PubMed:18093976}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:24658146}. Cell projection, neuron projection {ECO:0000269|PubMed:12417734, ECO:0000269|PubMed:15380484, ECO:0000269|PubMed:18093976}. Cell projection, axon {ECO:0000250|UniProtKB:P35922}. Cell projection, dendrite {ECO:0000250|UniProtKB:P35922}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P35922}. Synapse, synaptosome {ECO:0000250|UniProtKB:P35922}. Cell projection, growth cone {ECO:0000269|PubMed:15380484}. Cell projection, filopodium tip {ECO:0000250|UniProtKB:P35922}. Synapse {ECO:0000250|UniProtKB:P35922}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P35922}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P35922}. Nucleus {ECO:0000269|PubMed:10196376, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:18936162, ECO:0000269|PubMed:31753916}. Nucleus, nucleolus {ECO:0000269|PubMed:12837692, ECO:0000269|PubMed:16407062, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:24658146}. Chromosome, centromere {ECO:0000250|UniProtKB:P35922}. Chromosome {ECO:0000250|UniProtKB:P35922}. Cell membrane {ECO:0000250|UniProtKB:P35922}. Note=Mediates formation and localizes to cytoplasmic ribonucleoprotein membraneless compartments (PubMed:30765518, PubMed:31439799). Localizes to cytoplasmic ribonucleoprotein granules, also referred to as messenger ribonucleoprotein particles or mRNPs, along dendrites and dendritic spines (PubMed:9659908, PubMed:14532325). FMR1-containing cytoplasmic granules colocalize to F-actin-rich structures, including filopodium, spines and growth cone during the development of hippocampal neurons (By similarity). FMR1-containing cytoplasmic granules are transported out of the soma along axon and dendrite to synaptic contacts in a microtubule- and kinesin-dependent manner (PubMed:12417734, PubMed:15380484). Colocalizes with FXR1 and FXR2 in discrete granules, called fragile X granules (FXGs), along axon and presynaptic compartments (By similarity). Colocalizes with TDRD3 in cytoplasmic stress granules (SGs) in response to various cellular stress (PubMed:18632687, PubMed:18664458, PubMed:16636078). Colocalizes with FXR1, kinesin, 60S acidic ribosomal protein RPLP0 and SMN in cytoplasmic granules in the soma and neurite cell processes (PubMed:12417734, PubMed:18093976, PubMed:16636078). Colocalizes with H2AX/H2A.x in pericentromeric heterochromatin in response to DNA damaging agents (By similarity). Localizes on meiotic pachytene-stage chromosomes (By similarity). Forms nuclear foci representing sites of ongoing DNA replication in response to DNA damaging agents (By similarity). Shuttles between nucleus and cytoplasm in a XPO1/CRM1-dependent manner (PubMed:10196376). Colocalizes with CACNA1B in the cytoplasm and at the cell membrane of neurons (By similarity). Colocalizes with CYFIP1, CYFIP2, NXF2 and ribosomes in the perinuclear region (By similarity). Colocalizes with CYFIP1 and EIF4E in dendrites and probably at synapses (By similarity). {ECO:0000250|UniProtKB:P35922, ECO:0000250|UniProtKB:Q80WE1, ECO:0000269|PubMed:10196376, ECO:0000269|PubMed:12417734, ECO:0000269|PubMed:14532325, ECO:0000269|PubMed:15380484, ECO:0000269|PubMed:16636078, ECO:0000269|PubMed:18093976, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:18664458, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:9659908}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000269|PubMed:24204304, ECO:0000269|PubMed:8789445}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:24204304}.; SUBCELLULAR LOCATION: [Isoform 9]: Cytoplasm {ECO:0000269|PubMed:24204304, ECO:0000269|PubMed:8789445}.; SUBCELLULAR LOCATION: [Isoform 10]: Nucleus {ECO:0000269|PubMed:8789445}. Nucleus, Cajal body {ECO:0000269|PubMed:24204304}. Note=Colocalizes with Colin and SMN in Cajal bodies (PubMed:24204304).; SUBCELLULAR LOCATION: [Isoform 11]: Nucleus {ECO:0000269|PubMed:8789445}. Nucleus, Cajal body {ECO:0000269|PubMed:24204304}.
Q06828	reviewed	FMOD_HUMAN	Fibromodulin (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin)	FMOD FM SLRR2E	Homo sapiens (Human)	376	FUNCTION: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). {ECO:0000250}.		collagen fibril organization [GO:0030199]; transforming growth factor beta receptor complex assembly [GO:0007181]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]		collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; collagen fibril organization [GO:0030199]; transforming growth factor beta receptor complex assembly [GO:0007181]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q06830	reviewed	PRDX1_HUMAN	Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1)	PRDX1 PAGA PAGB TDPX2	Homo sapiens (Human)	199	FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}.	MISCELLANEOUS: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin. {ECO:0000305|Ref.31}.	cell population proliferation [GO:0008283]; cell redox homeostasis [GO:0045454]; erythrocyte homeostasis [GO:0034101]; fibroblast proliferation [GO:0048144]; hydrogen peroxide catabolic process [GO:0042744]; leukocyte activation [GO:0045321]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of stress-activated MAPK cascade [GO:0032872]; removal of superoxide radicals [GO:0019430]; response to oxidative stress [GO:0006979]; retina homeostasis [GO:0001895]; skeletal system development [GO:0001501]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; peroxidase activity [GO:0004601]; RNA binding [GO:0003723]; thioredoxin peroxidase activity [GO:0008379]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; peroxidase activity [GO:0004601]; RNA binding [GO:0003723]; thioredoxin peroxidase activity [GO:0008379]; cell population proliferation [GO:0008283]; cell redox homeostasis [GO:0045454]; erythrocyte homeostasis [GO:0034101]; fibroblast proliferation [GO:0048144]; hydrogen peroxide catabolic process [GO:0042744]; leukocyte activation [GO:0045321]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of stress-activated MAPK cascade [GO:0032872]; removal of superoxide radicals [GO:0019430]; response to oxidative stress [GO:0006979]; retina homeostasis [GO:0001895]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:9497357}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Q06889	reviewed	EGR3_HUMAN	Early growth response protein 3 (EGR-3) (Zinc finger protein pilot)	EGR3 PILOT	Homo sapiens (Human)	387	FUNCTION: Probable transcription factor involved in muscle spindle development.		cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; circadian rhythm [GO:0007623]; endothelial cell chemotaxis [GO:0035767]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; neuromuscular synaptic transmission [GO:0007274]; peripheral nervous system development [GO:0007422]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of T cell differentiation in thymus [GO:0033089]; regulation of gamma-delta T cell differentiation [GO:0045586]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; synapse [GO:0045202]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; synapse [GO:0045202]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; circadian rhythm [GO:0007623]; endothelial cell chemotaxis [GO:0035767]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; neuromuscular synaptic transmission [GO:0007274]; peripheral nervous system development [GO:0007422]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of T cell differentiation in thymus [GO:0033089]; regulation of gamma-delta T cell differentiation [GO:0045586]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q06945	reviewed	SOX4_HUMAN	Transcription factor SOX-4	SOX4	Homo sapiens (Human)	474	FUNCTION: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311). {ECO:0000250|UniProtKB:Q06831, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:30661772}.		anatomical structure morphogenesis [GO:0009653]; ascending aorta morphogenesis [GO:0035910]; atrial septum primum morphogenesis [GO:0003289]; cardiac right ventricle morphogenesis [GO:0003215]; cell differentiation [GO:0030154]; cellular response to glucose stimulus [GO:0071333]; endocrine pancreas development [GO:0031018]; gene expression [GO:0010467]; glial cell development [GO:0021782]; glial cell proliferation [GO:0014009]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; hematopoietic stem cell homeostasis [GO:0061484]; kidney morphogenesis [GO:0060993]; mesenchyme development [GO:0060485]; mitral valve morphogenesis [GO:0003183]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuroepithelial cell differentiation [GO:0060563]; noradrenergic neuron differentiation [GO:0003357]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of insulin secretion [GO:0032024]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of N-terminal peptidyl-lysine acetylation [GO:2000761]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; pro-B cell differentiation [GO:0002328]; protein stabilization [GO:0050821]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein stability [GO:0031647]; response to hypoxia [GO:0001666]; somatic stem cell population maintenance [GO:0035019]; spinal cord development [GO:0021510]; sympathetic nervous system development [GO:0048485]; T cell differentiation [GO:0030217]; ventricular septum morphogenesis [GO:0060412]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; miRNA binding [GO:0035198]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; miRNA binding [GO:0035198]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; ascending aorta morphogenesis [GO:0035910]; atrial septum primum morphogenesis [GO:0003289]; cardiac right ventricle morphogenesis [GO:0003215]; cell differentiation [GO:0030154]; cellular response to glucose stimulus [GO:0071333]; endocrine pancreas development [GO:0031018]; gene expression [GO:0010467]; glial cell development [GO:0021782]; glial cell proliferation [GO:0014009]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; hematopoietic stem cell homeostasis [GO:0061484]; kidney morphogenesis [GO:0060993]; mesenchyme development [GO:0060485]; mitral valve morphogenesis [GO:0003183]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuroepithelial cell differentiation [GO:0060563]; noradrenergic neuron differentiation [GO:0003357]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of insulin secretion [GO:0032024]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of N-terminal peptidyl-lysine acetylation [GO:2000761]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; pro-B cell differentiation [GO:0002328]; protein stabilization [GO:0050821]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein stability [GO:0031647]; response to hypoxia [GO:0001666]; somatic stem cell population maintenance [GO:0035019]; spinal cord development [GO:0021510]; sympathetic nervous system development [GO:0048485]; T cell differentiation [GO:0030217]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:16631117}.
Q07001	reviewed	ACHD_HUMAN	Acetylcholine receptor subunit delta	CHRND ACHRD	Homo sapiens (Human)	517	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. {ECO:0000269|PubMed:27375219}.		acetylcholine receptor signaling pathway [GO:0095500]; muscle contraction [GO:0006936]; musculoskeletal movement [GO:0050881]; neuromuscular process [GO:0050905]; signal transduction [GO:0007165]; skeletal muscle contraction [GO:0003009]; skeletal muscle tissue growth [GO:0048630]	acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]	acetylcholine binding [GO:0042166]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; acetylcholine binding [GO:0042166]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; acetylcholine receptor signaling pathway [GO:0095500]; muscle contraction [GO:0006936]; musculoskeletal movement [GO:0050881]; neuromuscular process [GO:0050905]; signal transduction [GO:0007165]; skeletal muscle contraction [GO:0003009]; skeletal muscle tissue growth [GO:0048630]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Q07002	reviewed	CDK18_HUMAN	Cyclin-dependent kinase 18 (EC 2.7.11.22) (Cell division protein kinase 18) (PCTAIRE-motif protein kinase 3) (Serine/threonine-protein kinase PCTAIRE-3)	CDK18 PCTAIRE3 PCTK3	Homo sapiens (Human)	474	FUNCTION: May play a role in signal transduction cascades in terminally differentiated cells.		phosphorylation [GO:0016310]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; phosphorylation [GO:0016310]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	
Q07011	reviewed	TNR9_HUMAN	Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (CDw137) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD antigen CD137)	TNFRSF9 CD137 ILA	Homo sapiens (Human)	255	FUNCTION: Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable). {ECO:0000305|PubMed:30872117}.		apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell population proliferation [GO:0042127]; regulation of immature T cell proliferation in thymus [GO:0033084]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell population proliferation [GO:0042127]; regulation of immature T cell proliferation in thymus [GO:0033084]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein {ECO:0000305|PubMed:30872117}.
Q07020	reviewed	RL18_HUMAN	Large ribosomal subunit protein eL18 (60S ribosomal protein L18)	RPL18	Homo sapiens (Human)	188	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; rough endoplasmic reticulum [GO:0005791]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; rough endoplasmic reticulum [GO:0005791]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q95342}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q95342, ECO:0000269|PubMed:25957688}.
Q07021	reviewed	C1QBP_HUMAN	Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32)	C1QBP GC1QBP HABP1 SF2P32	Homo sapiens (Human)	282	FUNCTION: Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection. {ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10479529, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:11859136, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16140380, ECO:0000269|PubMed:16177118, ECO:0000269|PubMed:17881511, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19004836, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20810993, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:28942965, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:8710908, ECO:0000269|PubMed:9461517}.; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269|PubMed:12833064}.; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. {ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:12411480}.; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. {ECO:0000269|PubMed:12034482}.		apoptotic process [GO:0006915]; complement activation, classical pathway [GO:0006958]; cytosolic ribosome assembly [GO:0042256]; immune response [GO:0006955]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of complement activation [GO:0030449]; RNA splicing [GO:0008380]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	adrenergic receptor binding [GO:0031690]; complement component C1q complex binding [GO:0001849]; hyaluronic acid binding [GO:0005540]; kininogen binding [GO:0030984]; mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; adrenergic receptor binding [GO:0031690]; complement component C1q complex binding [GO:0001849]; hyaluronic acid binding [GO:0005540]; kininogen binding [GO:0030984]; mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; apoptotic process [GO:0006915]; complement activation, classical pathway [GO:0006958]; cytosolic ribosome assembly [GO:0042256]; immune response [GO:0006955]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of complement activation [GO:0030449]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:15031724, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:9305894}. Nucleus {ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:9299613}. Nucleus, nucleolus {ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:32958672}. Cell membrane {ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:11493647, ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:9191880, ECO:0000269|PubMed:9233640}; Peripheral membrane protein {ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:9191880}; Extracellular side. Secreted. Cytoplasm {ECO:0000269|PubMed:11493647, ECO:0000269|PubMed:9299613}. Note=Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes. Localizes to the nucleolus when coexpressed with POLGARF (PubMed:32958672). Interaction with POLGARF is likely to result in prevention of C1QBP maturation and redirection from mitochondria to nucleoli (PubMed:32958672). {ECO:0000269|PubMed:32958672}.
Q07065	reviewed	CKAP4_HUMAN	Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63)	CKAP4	Homo sapiens (Human)	602	FUNCTION: Mediates the anchoring of the endoplasmic reticulum to microtubules. {ECO:0000269|PubMed:15703217}.; FUNCTION: High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells. {ECO:0000269|PubMed:17030514, ECO:0000269|PubMed:19144824}.			azurophil granule membrane [GO:0035577]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; lamellar body [GO:0042599]; lipid droplet [GO:0005811]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; specific granule membrane [GO:0035579]	RNA binding [GO:0003723]	azurophil granule membrane [GO:0035577]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; lamellar body [GO:0042599]; lipid droplet [GO:0005811]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; specific granule membrane [GO:0035579]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824}; Single-pass type II membrane protein. Cell membrane {ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824}; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation.
Q07075	reviewed	AMPE_HUMAN	Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249)	ENPEP	Homo sapiens (Human)	957	FUNCTION: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. {ECO:0000305|PubMed:23888046}.		angiogenesis [GO:0001525]; angiotensin maturation [GO:0002003]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell signaling [GO:0007267]; glomerulus development [GO:0032835]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]; angiogenesis [GO:0001525]; angiotensin maturation [GO:0002003]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell signaling [GO:0007267]; glomerulus development [GO:0032835]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10692253}; Single-pass type II membrane protein.
Q07092	reviewed	COGA1_HUMAN	Collagen alpha-1(XVI) chain	COL16A1 FP1572	Homo sapiens (Human)	1604	FUNCTION: Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology. {ECO:0000269|PubMed:16754661}.		cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cellular response to amino acid stimulus [GO:0071230]; extracellular matrix organization [GO:0030198]; female pregnancy [GO:0007565]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of focal adhesion assembly [GO:0051894]	collagen type IX trimer [GO:0005594]; collagen type XVI trimer [GO:0005597]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; integrin binding [GO:0005178]	collagen type IX trimer [GO:0005594]; collagen type XVI trimer [GO:0005597]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cellular response to amino acid stimulus [GO:0071230]; extracellular matrix organization [GO:0030198]; female pregnancy [GO:0007565]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of focal adhesion assembly [GO:0051894]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:9022684}.
Q07108	reviewed	CD69_HUMAN	Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69)	CD69 CLEC2C	Homo sapiens (Human)	199	FUNCTION: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.		cellular response to xenobiotic stimulus [GO:0071466]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]; cellular response to xenobiotic stimulus [GO:0071466]	SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
Q07157	reviewed	ZO1_HUMAN	Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)	TJP1 ZO1	Homo sapiens (Human)	1748	FUNCTION: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.		actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; adherens junction maintenance [GO:0034334]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of apoptotic process [GO:0043066]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of blood-brain barrier permeability [GO:1905605]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of sprouting angiogenesis [GO:1903672]; protein localization to adherens junction [GO:0071896]; protein localization to bicellular tight junction [GO:1902396]; protein localization to cell-cell junction [GO:0150105]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cell junction assembly [GO:1901888]; regulation of cytoskeleton organization [GO:0051493]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; gap junction [GO:0005921]; plasma membrane [GO:0005886]; podosome [GO:0002102]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]	cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; cell adhesion molecule binding [GO:0050839]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; gap junction [GO:0005921]; plasma membrane [GO:0005886]; podosome [GO:0002102]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; cell adhesion molecule binding [GO:0050839]; actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; adherens junction maintenance [GO:0034334]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of apoptotic process [GO:0043066]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of blood-brain barrier permeability [GO:1905605]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of sprouting angiogenesis [GO:1903672]; protein localization to adherens junction [GO:0071896]; protein localization to bicellular tight junction [GO:1902396]; protein localization to cell-cell junction [GO:0150105]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cell junction assembly [GO:1901888]; regulation of cytoskeleton organization [GO:0051493]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7798316}; Peripheral membrane protein {ECO:0000269|PubMed:7798316}; Cytoplasmic side {ECO:0000269|PubMed:7798316}. Cell junction, tight junction {ECO:0000269|PubMed:7798316}. Cell junction {ECO:0000269|PubMed:28169360}. Cell junction, gap junction. Cell projection, podosome {ECO:0000269|PubMed:20930113}. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact (PubMed:7798316). At podosomal sites, is predominantly localized in the ring structure surrounding the actin core (PubMed:20930113). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225). {ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:31473225, ECO:0000269|PubMed:7798316}.
Q07283	reviewed	TRHY_HUMAN	Trichohyalin	TCHH THH THL TRHY	Homo sapiens (Human)	1943	FUNCTION: Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.		intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]	calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914]	cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
Q07325	reviewed	CXCL9_HUMAN	C-X-C motif chemokine 9 (Gamma-interferon-induced monokine) (Monokine induced by interferon-gamma) (HuMIG) (MIG) (Small-inducible cytokine B9)	CXCL9 CMK MIG SCYB9	Homo sapiens (Human)	125	FUNCTION: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; defense response [GO:0006952]; defense response to virus [GO:0051607]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; cytokine activity [GO:0005125]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; cytokine activity [GO:0005125]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; defense response [GO:0006952]; defense response to virus [GO:0051607]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
Q07326	reviewed	PIGF_HUMAN	Phosphatidylinositol-glycan biosynthesis class F protein (PIG-F) (GPI11 homolog)	PIGF	Homo sapiens (Human)	219	FUNCTION: Involved in GPI-anchor biosynthesis (PubMed:33386993). It acts through the transfer of ethanolamine phosphate to the third mannose of GPI. {ECO:0000250, ECO:0000269|PubMed:33386993}.		GPI anchor biosynthetic process [GO:0006506]	endoplasmic reticulum membrane [GO:0005789]	ethanolaminephosphotransferase activity [GO:0004307]; mannose-ethanolamine phosphotransferase activity [GO:0051377]	endoplasmic reticulum membrane [GO:0005789]; ethanolaminephosphotransferase activity [GO:0004307]; mannose-ethanolamine phosphotransferase activity [GO:0051377]; GPI anchor biosynthetic process [GO:0006506]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q07343	reviewed	PDE4B_HUMAN	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32)	PDE4B DPDE4	Homo sapiens (Human)	736	FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978}.		cAMP catabolic process [GO:0006198]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; leukocyte migration [GO:0050900]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0140199]; negative regulation of relaxation of cardiac muscle [GO:1901898]; neutrophil chemotaxis [GO:0030593]; neutrophil homeostasis [GO:0001780]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of type II interferon production [GO:0032729]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of high voltage-gated calcium channel activity [GO:1901841]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]	centrosome [GO:0005813]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; gamma-tubulin complex [GO:0000930]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; cAMP binding [GO:0030552]; gamma-tubulin binding [GO:0043015]; metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]	centrosome [GO:0005813]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; gamma-tubulin complex [GO:0000930]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; cAMP binding [GO:0030552]; gamma-tubulin binding [GO:0043015]; metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]; cAMP catabolic process [GO:0006198]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; leukocyte migration [GO:0050900]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0140199]; negative regulation of relaxation of cardiac muscle [GO:1901898]; neutrophil chemotaxis [GO:0030593]; neutrophil homeostasis [GO:0001780]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of type II interferon production [GO:0032729]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of high voltage-gated calcium channel activity [GO:1901841]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: [Isoform PDE4B5]: Cytoplasm {ECO:0000269|PubMed:17519386}. Cell membrane {ECO:0000269|PubMed:17519386}.
Q07352	reviewed	TISB_HUMAN	mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1)	ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B	Homo sapiens (Human)	338	FUNCTION: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity). {ECO:0000250|UniProtKB:P17431, ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:12198173, ECO:0000269|PubMed:15467755, ECO:0000269|PubMed:15538381, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17030608, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18326031, ECO:0000269|PubMed:19179481, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21832157, ECO:0000269|PubMed:24700863, ECO:0000269|PubMed:25014217, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:26542173, ECO:0000269|PubMed:27182009}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; apoptotic process [GO:0006915]; cell population proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to raffinose [GO:0097403]; cellular response to salt stress [GO:0071472]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; chorio-allantoic fusion [GO:0060710]; ERK1 and ERK2 cascade [GO:0070371]; heart development [GO:0007507]; MAPK cascade [GO:0000165]; mesendoderm development [GO:0048382]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; multicellular organism growth [GO:0035264]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; neural tube development [GO:0021915]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; p38MAPK cascade [GO:0038066]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; proepicardium development [GO:0003342]; regulation of B cell differentiation [GO:0045577]; regulation of gene expression [GO:0010468]; regulation of keratinocyte apoptotic process [GO:1902172]; regulation of keratinocyte differentiation [GO:0045616]; regulation of keratinocyte proliferation [GO:0010837]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of mRNA stability [GO:0043488]; regulation of myoblast differentiation [GO:0045661]; regulation of stem cell proliferation [GO:0072091]; response to wounding [GO:0009611]; spongiotrophoblast layer development [GO:0060712]; T cell differentiation in thymus [GO:0033077]; vasculogenesis [GO:0001570]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]	14-3-3 protein binding [GO:0071889]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]; 14-3-3 protein binding [GO:0071889]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; apoptotic process [GO:0006915]; cell population proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to raffinose [GO:0097403]; cellular response to salt stress [GO:0071472]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; chorio-allantoic fusion [GO:0060710]; ERK1 and ERK2 cascade [GO:0070371]; heart development [GO:0007507]; MAPK cascade [GO:0000165]; mesendoderm development [GO:0048382]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; multicellular organism growth [GO:0035264]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; neural tube development [GO:0021915]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; p38MAPK cascade [GO:0038066]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; proepicardium development [GO:0003342]; regulation of B cell differentiation [GO:0045577]; regulation of gene expression [GO:0010468]; regulation of keratinocyte apoptotic process [GO:1902172]; regulation of keratinocyte differentiation [GO:0045616]; regulation of keratinocyte proliferation [GO:0010837]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of mRNA stability [GO:0043488]; regulation of myoblast differentiation [GO:0045661]; regulation of stem cell proliferation [GO:0072091]; response to wounding [GO:0009611]; spongiotrophoblast layer development [GO:0060712]; T cell differentiation in thymus [GO:0033077]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12198173}. Cytoplasm {ECO:0000269|PubMed:12198173}. Cytoplasmic granule {ECO:0000269|PubMed:15967811}. Cytoplasm, P-body {ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17369404}. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (By similarity). Component of cytoplasmic stress granules (PubMed:15967811). Localizes in processing bodies (PBs) (PubMed:17369404). {ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17369404}.
Q07444	reviewed	NKG2E_HUMAN	NKG2-E type II integral membrane protein (NK cell receptor E) (NKG2-E-activating NK receptor)	KLRC3 NKG2E	Homo sapiens (Human)	240	FUNCTION: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.		cellular defense response [GO:0006968]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888]; cellular defense response [GO:0006968]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
Q07617	reviewed	SPAG1_HUMAN	Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1)	SPAG1	Homo sapiens (Human)	926	FUNCTION: May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558}.	MISCELLANEOUS: Antibodies against SPAG1 interfere with fertilization. {ECO:0000250}.	axonemal dynein complex assembly [GO:0070286]; protein stabilization [GO:0050821]; single fertilization [GO:0007338]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; protein folding chaperone complex [GO:0101031]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; protein folding chaperone complex [GO:0101031]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; axonemal dynein complex assembly [GO:0070286]; protein stabilization [GO:0050821]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:16983343}. Dynein axonemal particle {ECO:0000305}. Note=Colocalizes with tubulin.
Q07627	reviewed	KRA11_HUMAN	Keratin-associated protein 1-1 (High sulfur keratin-associated protein 1.1) (Keratin-associated protein 1.1) (Keratin-associated protein 1.6) (Keratin-associated protein 1.7)	KRTAP1-1 B2A KAP1.1 KAP1.6 KAP1.7 KRTAP1.1	Homo sapiens (Human)	177	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q07654	reviewed	TFF3_HUMAN	Trefoil factor 3 (Intestinal trefoil factor) (hITF) (Polypeptide P1.B) (hP1.B)	TFF3 ITF TFI	Homo sapiens (Human)	80	FUNCTION: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). {ECO:0000269|PubMed:11694446}.		maintenance of gastrointestinal epithelium [GO:0030277]; regulation of glucose metabolic process [GO:0010906]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]	identical protein binding [GO:0042802]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; identical protein binding [GO:0042802]; maintenance of gastrointestinal epithelium [GO:0030277]; regulation of glucose metabolic process [GO:0010906]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:8454642}. Cytoplasm {ECO:0000269|PubMed:10824705, ECO:0000269|PubMed:8454642}.
Q07666	reviewed	KHDR1_HUMAN	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)	KHDRBS1 SAM68	Homo sapiens (Human)	443	FUNCTION: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}.		G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of translational initiation [GO:0045948]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA export from nucleus [GO:0046831]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Grb2-Sos complex [GO:0070618]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; protein domain specific binding [GO:0019904]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Grb2-Sos complex [GO:0070618]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; protein domain specific binding [GO:0019904]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of translational initiation [GO:0045948]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA export from nucleus [GO:0046831]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1374686, ECO:0000269|PubMed:29496907}. Cytoplasm {ECO:0000269|PubMed:29496907}. Membrane {ECO:0000269|PubMed:1374686}. Note=Predominantly located in the nucleus but also located partially in the cytoplasm. {ECO:0000269|PubMed:29496907}.
Q07687	reviewed	DLX2_HUMAN	Homeobox protein DLX-2	DLX2	Homo sapiens (Human)	328	FUNCTION: Acts as a transcriptional activator (By similarity). Activates transcription of CGA/alpha-GSU, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis (By similarity). {ECO:0000250|UniProtKB:P40764}.		brain development [GO:0007420]; branching morphogenesis of a nerve [GO:0048755]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cerebral cortex GABAergic interneuron fate commitment [GO:0021893]; embryonic cranial skeleton morphogenesis [GO:0048701]; forebrain neuron differentiation [GO:0021879]; hippocampus development [GO:0021766]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast differentiation [GO:0014016]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; olfactory bulb development [GO:0021772]; oligodendrocyte differentiation [GO:0048709]; positive regulation of amacrine cell differentiation [GO:1902871]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; subpallium development [GO:0021544]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded RNA binding [GO:0003727]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded RNA binding [GO:0003727]; transcription cis-regulatory region binding [GO:0000976]; brain development [GO:0007420]; branching morphogenesis of a nerve [GO:0048755]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cerebral cortex GABAergic interneuron fate commitment [GO:0021893]; embryonic cranial skeleton morphogenesis [GO:0048701]; forebrain neuron differentiation [GO:0021879]; hippocampus development [GO:0021766]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast differentiation [GO:0014016]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; olfactory bulb development [GO:0021772]; oligodendrocyte differentiation [GO:0048709]; positive regulation of amacrine cell differentiation [GO:1902871]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; subpallium development [GO:0021544]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q07699	reviewed	SCN1B_HUMAN	Sodium channel subunit beta-1	SCN1B	Homo sapiens (Human)	218	FUNCTION: Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. {ECO:0000269|PubMed:14622265, ECO:0000269|PubMed:15525788, ECO:0000269|PubMed:18464934, ECO:0000269|PubMed:19710327, ECO:0000269|PubMed:21994374, ECO:0000269|PubMed:29992740, ECO:0000269|PubMed:36696443, ECO:0000269|PubMed:8125980, ECO:0000269|PubMed:8394762}.; FUNCTION: [Isoform 2]: Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth (PubMed:21994374). Has no regulatory function on the SCN2A sodium channel complex (PubMed:14622265). {ECO:0000269|PubMed:14622265, ECO:0000269|PubMed:21994374}.	MISCELLANEOUS: [Isoform 2]: Due to intron 3 retention. {ECO:0000305}.	axon guidance [GO:0007411]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; cell adhesion [GO:0007155]; corticospinal neuron axon guidance [GO:0021966]; locomotion [GO:0040011]; membrane depolarization [GO:0051899]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; neuronal action potential propagation [GO:0019227]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of voltage-gated sodium channel activity [GO:1905152]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sodium ion transmembrane transport [GO:0035725]	extracellular region [GO:0005576]; intercalated disc [GO:0014704]; node of Ranvier [GO:0033268]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518]	sodium channel inhibitor activity [GO:0019871]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]; voltage-gated sodium channel activity involved in Purkinje myocyte action potential [GO:0086062]	extracellular region [GO:0005576]; intercalated disc [GO:0014704]; node of Ranvier [GO:0033268]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518]; sodium channel inhibitor activity [GO:0019871]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]; voltage-gated sodium channel activity involved in Purkinje myocyte action potential [GO:0086062]; axon guidance [GO:0007411]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; cell adhesion [GO:0007155]; corticospinal neuron axon guidance [GO:0021966]; locomotion [GO:0040011]; membrane depolarization [GO:0051899]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; neuronal action potential propagation [GO:0019227]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of voltage-gated sodium channel activity [GO:1905152]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:17928445, ECO:0000269|PubMed:19710327, ECO:0000269|PubMed:21994374, ECO:0000269|PubMed:29992740, ECO:0000269|PubMed:30190309, ECO:0000305|PubMed:8125980}; Single-pass type I membrane protein {ECO:0000269|PubMed:30190309, ECO:0000305|PubMed:8125980}. Perikaryon {ECO:0000250|UniProtKB:P97952}. Cell projection {ECO:0000250|UniProtKB:P97952}. Cell projection, axon {ECO:0000250|UniProtKB:Q00954}. Note=Detected at nodes of Ranvier on the sciatic nerve. {ECO:0000250|UniProtKB:Q00954}.; SUBCELLULAR LOCATION: [Isoform 2]: Perikaryon {ECO:0000269|PubMed:14622265}. Cell projection {ECO:0000269|PubMed:14622265}. Secreted {ECO:0000269|PubMed:21994374}. Note=Detected on Purkinje cells and their cell projections and on neuronal cell projections. {ECO:0000269|PubMed:14622265}.
Q07812	reviewed	BAX_HUMAN	Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)	BAX BCL2L4	Homo sapiens (Human)	192	FUNCTION: Plays a role in the mitochondrial apoptotic process (PubMed:10772918, PubMed:16113678, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:8358790, PubMed:8521816, PubMed:11060313, PubMed:16199525, PubMed:36361894). Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis (PubMed:11060313, PubMed:16199525, PubMed:10772918, PubMed:16113678, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:8358790, PubMed:8521816). Promotes activation of CASP3, and thereby apoptosis (PubMed:11060313, PubMed:16199525, PubMed:10772918, PubMed:16113678, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:8358790, PubMed:8521816). {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:11060313, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:16199525, ECO:0000269|PubMed:18948948, ECO:0000269|PubMed:21199865, ECO:0000269|PubMed:21458670, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:36361894, ECO:0000269|PubMed:8358790, ECO:0000269|PubMed:8521816}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic mitochondrial changes [GO:0008637]; apoptotic process [GO:0006915]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; apoptotic process involved in mammary gland involution [GO:0060057]; apoptotic signaling pathway [GO:0097190]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell homeostatic proliferation [GO:0002358]; B cell negative selection [GO:0002352]; B cell receptor apoptotic signaling pathway [GO:1990117]; blood vessel remodeling [GO:0001974]; calcium ion transport into cytosol [GO:0060402]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; cellular response to virus [GO:0098586]; cerebral cortex development [GO:0021987]; development of secondary sexual characteristics [GO:0045136]; ectopic germ cell programmed cell death [GO:0035234]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial cell apoptotic process [GO:1904019]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; fertilization [GO:0009566]; germ cell development [GO:0007281]; glycosphingolipid metabolic process [GO:0006687]; homeostasis of number of cells within a tissue [GO:0048873]; hypothalamus development [GO:0021854]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; mitochondrion morphogenesis [GO:0070584]; motor neuron apoptotic process [GO:0097049]; myeloid cell homeostasis [GO:0002262]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein binding [GO:0032091]; neuron migration [GO:0001764]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of developmental pigmentation [GO:0048087]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of motor neuron apoptotic process [GO:2000673]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of reproductive process [GO:2000243]; post-embryonic camera-type eye morphogenesis [GO:0048597]; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:0001844]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of nitrogen utilization [GO:0006808]; release of cytochrome c from mitochondria [GO:0001836]; release of matrix enzymes from mitochondria [GO:0032976]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; response to gamma radiation [GO:0010332]; response to salt stress [GO:0009651]; response to toxic substance [GO:0009636]; retina development in camera-type eye [GO:0060041]; retinal cell programmed cell death [GO:0046666]; Sertoli cell proliferation [GO:0060011]; spermatid differentiation [GO:0048515]; supramolecular fiber organization [GO:0097435]; T cell homeostatic proliferation [GO:0001777]; thymocyte apoptotic process [GO:0070242]; vagina development [GO:0060068]	BAK complex [GO:0097145]; BAX complex [GO:0097144]; Bcl-2 family protein complex [GO:0097136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; pore complex [GO:0046930]	BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	BAK complex [GO:0097145]; BAX complex [GO:0097144]; Bcl-2 family protein complex [GO:0097136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; pore complex [GO:0046930]; BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic mitochondrial changes [GO:0008637]; apoptotic process [GO:0006915]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; apoptotic process involved in mammary gland involution [GO:0060057]; apoptotic signaling pathway [GO:0097190]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell homeostatic proliferation [GO:0002358]; B cell negative selection [GO:0002352]; B cell receptor apoptotic signaling pathway [GO:1990117]; blood vessel remodeling [GO:0001974]; calcium ion transport into cytosol [GO:0060402]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; cellular response to virus [GO:0098586]; cerebral cortex development [GO:0021987]; development of secondary sexual characteristics [GO:0045136]; ectopic germ cell programmed cell death [GO:0035234]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial cell apoptotic process [GO:1904019]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; fertilization [GO:0009566]; germ cell development [GO:0007281]; glycosphingolipid metabolic process [GO:0006687]; homeostasis of number of cells within a tissue [GO:0048873]; hypothalamus development [GO:0021854]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; mitochondrion morphogenesis [GO:0070584]; motor neuron apoptotic process [GO:0097049]; myeloid cell homeostasis [GO:0002262]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein binding [GO:0032091]; neuron migration [GO:0001764]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of developmental pigmentation [GO:0048087]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of motor neuron apoptotic process [GO:2000673]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of reproductive process [GO:2000243]; post-embryonic camera-type eye morphogenesis [GO:0048597]; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:0001844]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of nitrogen utilization [GO:0006808]; release of cytochrome c from mitochondria [GO:0001836]; release of matrix enzymes from mitochondria [GO:0032976]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; response to gamma radiation [GO:0010332]; response to salt stress [GO:0009651]; response to toxic substance [GO:0009636]; retina development in camera-type eye [GO:0060041]; retinal cell programmed cell death [GO:0046666]; Sertoli cell proliferation [GO:0060011]; spermatid differentiation [GO:0048515]; supramolecular fiber organization [GO:0097435]; T cell homeostatic proliferation [GO:0001777]; thymocyte apoptotic process [GO:0070242]; vagina development [GO:0060068]	SUBCELLULAR LOCATION: [Isoform Alpha]: Mitochondrion outer membrane {ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:29531808}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:27558414, ECO:0000269|PubMed:29531808}. Nucleus {ECO:0000269|PubMed:36361894}. Note=Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane. Upon Sendai virus infection, recruited to the mitochondrion through interaction with IRF3 (PubMed:25609812). {ECO:0000269|PubMed:25609812}.; SUBCELLULAR LOCATION: [Isoform Beta]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform Gamma]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform Delta]: Cytoplasm {ECO:0000305}.
Q07817	reviewed	B2CL1_HUMAN	Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)	BCL2L1 BCL2L BCLX	Homo sapiens (Human)	233	FUNCTION: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:17418785}.; FUNCTION: Isoform Bcl-X(S) promotes apoptosis.		apoptotic mitochondrial changes [GO:0008637]; apoptotic process in bone marrow cell [GO:0071839]; cellular response to alkaloid [GO:0071312]; cellular response to amino acid stimulus [GO:0071230]; cellular response to gamma radiation [GO:0071480]; defense response to virus [GO:0051607]; dendritic cell apoptotic process [GO:0097048]; dendritic cell proliferation [GO:0044565]; ectopic germ cell programmed cell death [GO:0035234]; endocytosis [GO:0006897]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fertilization [GO:0009566]; germ cell development [GO:0007281]; hepatocyte apoptotic process [GO:0097284]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; male gonad development [GO:0008584]; mitochondrion morphogenesis [GO:0070584]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of developmental process [GO:0051093]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of reproductive process [GO:2000242]; neuron apoptotic process [GO:0051402]; ovarian follicle development [GO:0001541]; positive regulation of mononuclear cell proliferation [GO:0032946]; regulation of cytokinesis [GO:0032465]; regulation of growth [GO:0040008]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; release of cytochrome c from mitochondria [GO:0001836]; response to cycloheximide [GO:0046898]; response to cytokine [GO:0034097]; spermatogenesis [GO:0007283]; suppression by virus of host apoptotic process [GO:0019050]	Bcl-2 family protein complex [GO:0097136]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; synaptic vesicle membrane [GO:0030672]	BH3 domain binding [GO:0051434]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]	Bcl-2 family protein complex [GO:0097136]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; synaptic vesicle membrane [GO:0030672]; BH3 domain binding [GO:0051434]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; apoptotic mitochondrial changes [GO:0008637]; apoptotic process in bone marrow cell [GO:0071839]; cellular response to alkaloid [GO:0071312]; cellular response to amino acid stimulus [GO:0071230]; cellular response to gamma radiation [GO:0071480]; defense response to virus [GO:0051607]; dendritic cell apoptotic process [GO:0097048]; dendritic cell proliferation [GO:0044565]; ectopic germ cell programmed cell death [GO:0035234]; endocytosis [GO:0006897]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fertilization [GO:0009566]; germ cell development [GO:0007281]; hepatocyte apoptotic process [GO:0097284]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; male gonad development [GO:0008584]; mitochondrion morphogenesis [GO:0070584]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of developmental process [GO:0051093]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of reproductive process [GO:2000242]; neuron apoptotic process [GO:0051402]; ovarian follicle development [GO:0001541]; positive regulation of mononuclear cell proliferation [GO:0032946]; regulation of cytokinesis [GO:0032465]; regulation of growth [GO:0040008]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; release of cytochrome c from mitochondria [GO:0001836]; response to cycloheximide [GO:0046898]; response to cytokine [GO:0034097]; spermatogenesis [GO:0007283]; suppression by virus of host apoptotic process [GO:0019050]	SUBCELLULAR LOCATION: [Isoform Bcl-X(L)]: Mitochondrion inner membrane {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49. {ECO:0000250}.
Q07820	reviewed	MCL1_HUMAN	Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)	MCL1 BCL2L3	Homo sapiens (Human)	350	FUNCTION: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}.		cell fate determination [GO:0001709]; cellular homeostasis [GO:0019725]; DNA damage response [GO:0006974]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitochondrial fusion [GO:0008053]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of apoptotic process [GO:0043065]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; regulation of apoptotic process [GO:0042981]; release of cytochrome c from mitochondria [GO:0001836]; response to cytokine [GO:0034097]	Bcl-2 family protein complex [GO:0097136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein transmembrane transporter activity [GO:0008320]	Bcl-2 family protein complex [GO:0097136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein transmembrane transporter activity [GO:0008320]; cell fate determination [GO:0001709]; cellular homeostasis [GO:0019725]; DNA damage response [GO:0006974]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitochondrial fusion [GO:0008053]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of apoptotic process [GO:0043065]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; regulation of apoptotic process [GO:0042981]; release of cytochrome c from mitochondria [GO:0001836]; response to cytokine [GO:0034097]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
Q07837	reviewed	SLC31_HUMAN	Amino acid transporter heavy chain SLC3A1 (D2h) (Neutral and basic amino acid transport protein) (NBAT) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transporter-related heavy chain) (rBAT)	SLC3A1 NBAT	Homo sapiens (Human)	685	FUNCTION: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane (PubMed:16825196, PubMed:10588648, PubMed:32817565, PubMed:32494597, PubMed:11318953, PubMed:16609684, PubMed:8486766, PubMed:7686906, PubMed:8663184, PubMed:8663357) (By similarity). Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules (PubMed:10588648, PubMed:11318953, PubMed:16609684, PubMed:16825196, PubMed:32494597, PubMed:32817565, PubMed:7686906, PubMed:8486766, PubMed:8663184, PubMed:8663357). Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate (By similarity). {ECO:0000250|UniProtKB:Q91WV7, ECO:0000269|PubMed:10588648, ECO:0000269|PubMed:11318953, ECO:0000269|PubMed:16609684, ECO:0000269|PubMed:16825196, ECO:0000269|PubMed:32494597, ECO:0000269|PubMed:32817565, ECO:0000269|PubMed:7686906, ECO:0000269|PubMed:8486766, ECO:0000269|PubMed:8663184, ECO:0000269|PubMed:8663357}.		amino acid transport [GO:0006865]; aspartate transmembrane transport [GO:0015810]; basic amino acid transport [GO:0015802]; carbohydrate metabolic process [GO:0005975]; gene expression [GO:0010467]; L-cystine transport [GO:0015811]; L-glutamate transmembrane transport [GO:0015813]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]	amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-cystine transmembrane transporter activity [GO:0015184]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]; amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-cystine transmembrane transporter activity [GO:0015184]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]; amino acid transport [GO:0006865]; aspartate transmembrane transport [GO:0015810]; basic amino acid transport [GO:0015802]; carbohydrate metabolic process [GO:0005975]; gene expression [GO:0010467]; L-cystine transport [GO:0015811]; L-glutamate transmembrane transport [GO:0015813]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12167606, ECO:0000269|PubMed:32817565}; Single-pass type II membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q91WV7}; Single-pass type II membrane protein {ECO:0000255}.
Q07864	reviewed	DPOE1_HUMAN	DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A)	POLE POLE1	Homo sapiens (Human)	2286	FUNCTION: Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). {ECO:0000250|UniProtKB:P21951, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:27573199}.		base-excision repair, gap-filling [GO:0006287]; DNA replication [GO:0006260]; DNA replication proofreading [GO:0045004]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; embryonic organ development [GO:0048568]; G1/S transition of mitotic cell cycle [GO:0000082]; leading strand elongation [GO:0006272]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair, DNA gap filling [GO:0006297]	epsilon DNA polymerase complex [GO:0008622]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	4 iron, 4 sulfur cluster binding [GO:0051539]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; zinc ion binding [GO:0008270]	epsilon DNA polymerase complex [GO:0008622]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; zinc ion binding [GO:0008270]; base-excision repair, gap-filling [GO:0006287]; DNA replication [GO:0006260]; DNA replication proofreading [GO:0045004]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; embryonic organ development [GO:0048568]; G1/S transition of mitotic cell cycle [GO:0000082]; leading strand elongation [GO:0006272]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair, DNA gap filling [GO:0006297]	SUBCELLULAR LOCATION: Nucleus.
Q07866	reviewed	KLC1_HUMAN	Kinesin light chain 1 (KLC 1)	KLC1 KLC KNS2	Homo sapiens (Human)	573	FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250|UniProtKB:P37285, ECO:0000269|PubMed:21385839}.		cell adhesion [GO:0007155]; microtubule-based movement [GO:0007018]; stress granule disassembly [GO:0035617]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; growth cone [GO:0030426]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]	cytoskeletal motor activity [GO:0003774]; kinesin binding [GO:0019894]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; growth cone [GO:0030426]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; cytoskeletal motor activity [GO:0003774]; kinesin binding [GO:0019894]; cell adhesion [GO:0007155]; microtubule-based movement [GO:0007018]; stress granule disassembly [GO:0035617]	SUBCELLULAR LOCATION: Cell projection, growth cone {ECO:0000250|UniProtKB:P37285}. Cytoplasmic vesicle {ECO:0000269|PubMed:21385839}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:14970196}.
Q07869	reviewed	PPARA_HUMAN	Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)	PPARA NR1C1 PPAR	Homo sapiens (Human)	468	FUNCTION: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}.		behavioral response to nicotine [GO:0035095]; cell differentiation [GO:0030154]; cellular response to starvation [GO:0009267]; circadian regulation of gene expression [GO:0032922]; enamel mineralization [GO:0070166]; epidermis development [GO:0008544]; fatty acid metabolic process [GO:0006631]; gluconeogenesis [GO:0006094]; heart development [GO:0007507]; hormone-mediated signaling pathway [GO:0009755]; lipoprotein metabolic process [GO:0042157]; negative regulation of appetite [GO:0032099]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of glycolytic process [GO:0045820]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of sequestering of triglyceride [GO:0010891]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transformation of host cell by virus [GO:1904189]; regulation of cellular ketone metabolic process [GO:0010565]; regulation of circadian rhythm [GO:0042752]; regulation of fatty acid metabolic process [GO:0019217]; regulation of fatty acid transport [GO:2000191]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; wound healing [GO:0042060]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; lipid binding [GO:0008289]; MDM2/MDM4 family protein binding [GO:0097371]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; NFAT protein binding [GO:0051525]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; phosphatase binding [GO:0019902]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]; ubiquitin conjugating enzyme binding [GO:0031624]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; lipid binding [GO:0008289]; MDM2/MDM4 family protein binding [GO:0097371]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; NFAT protein binding [GO:0051525]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; phosphatase binding [GO:0019902]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]; ubiquitin conjugating enzyme binding [GO:0031624]; zinc ion binding [GO:0008270]; behavioral response to nicotine [GO:0035095]; cell differentiation [GO:0030154]; cellular response to starvation [GO:0009267]; circadian regulation of gene expression [GO:0032922]; enamel mineralization [GO:0070166]; epidermis development [GO:0008544]; fatty acid metabolic process [GO:0006631]; gluconeogenesis [GO:0006094]; heart development [GO:0007507]; hormone-mediated signaling pathway [GO:0009755]; lipoprotein metabolic process [GO:0042157]; negative regulation of appetite [GO:0032099]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of glycolytic process [GO:0045820]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of sequestering of triglyceride [GO:0010891]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transformation of host cell by virus [GO:1904189]; regulation of cellular ketone metabolic process [GO:0010565]; regulation of circadian rhythm [GO:0042752]; regulation of fatty acid metabolic process [GO:0019217]; regulation of fatty acid transport [GO:2000191]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Nucleus.
Q07889	reviewed	SOS1_HUMAN	Son of sevenless homolog 1 (SOS-1)	SOS1	Homo sapiens (Human)	1333	FUNCTION: Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}.		axon guidance [GO:0007411]; B cell homeostasis [GO:0001782]; B cell receptor signaling pathway [GO:0050853]; blood vessel morphogenesis [GO:0048514]; cardiac atrium morphogenesis [GO:0003209]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; eyelid development in camera-type eye [GO:0061029]; Fc-epsilon receptor signaling pathway [GO:0038095]; fibroblast growth factor receptor signaling pathway [GO:0008543]; hair follicle development [GO:0001942]; heart trabecula morphogenesis [GO:0061384]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; leukocyte migration [GO:0050900]; midbrain morphogenesis [GO:1904693]; multicellular organism growth [GO:0035264]; neurotrophin TRK receptor signaling pathway [GO:0048011]; pericardium morphogenesis [GO:0003344]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; Ras protein signal transduction [GO:0007265]; regulation of cell population proliferation [GO:0042127]; regulation of pro-B cell differentiation [GO:2000973]; regulation of T cell differentiation in thymus [GO:0033081]; regulation of T cell proliferation [GO:0042129]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ischemia [GO:0002931]; roof of mouth development [GO:0060021]; signal transduction [GO:0007165]; vitellogenesis [GO:0007296]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTPase complex [GO:1905360]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	epidermal growth factor receptor binding [GO:0005154]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular condensate scaffold activity [GO:0140693]; protein heterodimerization activity [GO:0046982]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTPase complex [GO:1905360]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; epidermal growth factor receptor binding [GO:0005154]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular condensate scaffold activity [GO:0140693]; protein heterodimerization activity [GO:0046982]; SH3 domain binding [GO:0017124]; axon guidance [GO:0007411]; B cell homeostasis [GO:0001782]; B cell receptor signaling pathway [GO:0050853]; blood vessel morphogenesis [GO:0048514]; cardiac atrium morphogenesis [GO:0003209]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; eyelid development in camera-type eye [GO:0061029]; Fc-epsilon receptor signaling pathway [GO:0038095]; fibroblast growth factor receptor signaling pathway [GO:0008543]; hair follicle development [GO:0001942]; heart trabecula morphogenesis [GO:0061384]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; leukocyte migration [GO:0050900]; midbrain morphogenesis [GO:1904693]; multicellular organism growth [GO:0035264]; neurotrophin TRK receptor signaling pathway [GO:0048011]; pericardium morphogenesis [GO:0003344]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; Ras protein signal transduction [GO:0007265]; regulation of cell population proliferation [GO:0042127]; regulation of pro-B cell differentiation [GO:2000973]; regulation of T cell differentiation in thymus [GO:0033081]; regulation of T cell proliferation [GO:0042129]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ischemia [GO:0002931]; roof of mouth development [GO:0060021]; signal transduction [GO:0007165]; vitellogenesis [GO:0007296]	
Q07890	reviewed	SOS2_HUMAN	Son of sevenless homolog 2 (SOS-2)	SOS2	Homo sapiens (Human)	1332	FUNCTION: Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000250|UniProtKB:Q62245}.		B cell homeostasis [GO:0001782]; insulin receptor signaling pathway [GO:0008286]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; Ras protein signal transduction [GO:0007265]; regulation of pro-B cell differentiation [GO:2000973]; regulation of T cell differentiation in thymus [GO:0033081]; regulation of T cell proliferation [GO:0042129]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; protein heterodimerization activity [GO:0046982]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein heterodimerization activity [GO:0046982]; B cell homeostasis [GO:0001782]; insulin receptor signaling pathway [GO:0008286]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; Ras protein signal transduction [GO:0007265]; regulation of pro-B cell differentiation [GO:2000973]; regulation of T cell differentiation in thymus [GO:0033081]; regulation of T cell proliferation [GO:0042129]	
Q07912	reviewed	ACK1_HUMAN	Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)	TNK2 ACK1	Homo sapiens (Human)	1038	FUNCTION: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell surface receptor signaling pathway [GO:0007166]; endocytosis [GO:0006897]; phosphorylation [GO:0016310]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of clathrin-dependent endocytosis [GO:2000369]; small GTPase mediated signal transduction [GO:0007264]	adherens junction [GO:0005912]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome [GO:0005768]; Grb2-EGFR complex [GO:0070436]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; epidermal growth factor receptor binding [GO:0005154]; GTPase inhibitor activity [GO:0005095]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]	adherens junction [GO:0005912]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome [GO:0005768]; Grb2-EGFR complex [GO:0070436]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; epidermal growth factor receptor binding [GO:0005154]; GTPase inhibitor activity [GO:0005095]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]; cell surface receptor signaling pathway [GO:0007166]; endocytosis [GO:0006897]; phosphorylation [GO:0016310]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of clathrin-dependent endocytosis [GO:2000369]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20979614}. Nucleus {ECO:0000269|PubMed:14733946, ECO:0000269|PubMed:20333297}. Endosome {ECO:0000250|UniProtKB:O54967}. Cell junction, adherens junction {ECO:0000305}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:16137687}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:16137687, ECO:0000269|PubMed:18262180}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:21169560}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20110370}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O54967}. Note=The Tyr-284 phosphorylated form is found both in the membrane and nucleus (By similarity). Co-localizes with EGFR on endosomes (PubMed:20333297). Nuclear translocation is CDC42-dependent (By similarity). Detected in long filamentous cytosolic structures where it co-localizes with CTPS1 (By similarity). {ECO:0000250|UniProtKB:O54967, ECO:0000269|PubMed:20333297}.
Q07954	reviewed	LRP1_HUMAN	Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]	LRP1 A2MR APR	Homo sapiens (Human)	4544	FUNCTION: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). {ECO:0000250|UniProtKB:Q91ZX7, ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657, ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:1702392, ECO:0000269|PubMed:26142438, ECO:0000269|PubMed:32296178}.; FUNCTION: (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}.		amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta clearance by transcytosis [GO:0150093]; aorta morphogenesis [GO:0035909]; apoptotic cell clearance [GO:0043277]; astrocyte activation involved in immune response [GO:0002265]; cellular response to amyloid-beta [GO:1904646]; enzyme-linked receptor protein signaling pathway [GO:0007167]; lipid metabolic process [GO:0006629]; lipoprotein transport [GO:0042953]; lysosomal transport [GO:0007041]; negative regulation of gene expression [GO:0010629]; negative regulation of metallopeptidase activity [GO:1905049]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of Wnt signaling pathway [GO:0030178]; phagocytosis [GO:0006909]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of endocytosis [GO:0045807]; positive regulation of lipid transport [GO:0032370]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of transcytosis [GO:1904300]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cholesterol transport [GO:0032374]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of phospholipase A2 activity [GO:0032429]; retinoid metabolic process [GO:0001523]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]	basolateral plasma membrane [GO:0016323]; clathrin-coated pit [GO:0005905]; cytoskeleton [GO:0005856]; early endosome [GO:0005769]; endocytic vesicle membrane [GO:0030666]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; receptor complex [GO:0043235]	alpha-2 macroglobulin receptor activity [GO:0016964]; amyloid-beta binding [GO:0001540]; apolipoprotein binding [GO:0034185]; apolipoprotein receptor activity [GO:0030226]; calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; clathrin heavy chain binding [GO:0032050]; heparan sulfate proteoglycan binding [GO:0043395]; lipoprotein particle receptor binding [GO:0070325]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; scavenger receptor activity [GO:0005044]; signaling receptor activity [GO:0038023]	basolateral plasma membrane [GO:0016323]; clathrin-coated pit [GO:0005905]; cytoskeleton [GO:0005856]; early endosome [GO:0005769]; endocytic vesicle membrane [GO:0030666]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; receptor complex [GO:0043235]; alpha-2 macroglobulin receptor activity [GO:0016964]; amyloid-beta binding [GO:0001540]; apolipoprotein binding [GO:0034185]; apolipoprotein receptor activity [GO:0030226]; calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; clathrin heavy chain binding [GO:0032050]; heparan sulfate proteoglycan binding [GO:0043395]; lipoprotein particle receptor binding [GO:0070325]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; scavenger receptor activity [GO:0005044]; signaling receptor activity [GO:0038023]; amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta clearance by transcytosis [GO:0150093]; aorta morphogenesis [GO:0035909]; apoptotic cell clearance [GO:0043277]; astrocyte activation involved in immune response [GO:0002265]; cellular response to amyloid-beta [GO:1904646]; enzyme-linked receptor protein signaling pathway [GO:0007167]; lipid metabolic process [GO:0006629]; lipoprotein transport [GO:0042953]; lysosomal transport [GO:0007041]; negative regulation of gene expression [GO:0010629]; negative regulation of metallopeptidase activity [GO:1905049]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of Wnt signaling pathway [GO:0030178]; phagocytosis [GO:0006909]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of endocytosis [GO:0045807]; positive regulation of lipid transport [GO:0032370]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of transcytosis [GO:1904300]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cholesterol transport [GO:0032374]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of phospholipase A2 activity [GO:0032429]; retinoid metabolic process [GO:0001523]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: [Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit.; SUBCELLULAR LOCATION: [Low-density lipoprotein receptor-related protein 1 515 kDa subunit]: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit.; SUBCELLULAR LOCATION: [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm {ECO:0000269|PubMed:12888553}. Nucleus {ECO:0000269|PubMed:12888553}. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:12888553}.; SUBCELLULAR LOCATION: Golgi outpost {ECO:0000250|UniProtKB:G3V928}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:G3V928}. Note=Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. {ECO:0000250|UniProtKB:G3V928}.
Q07955	reviewed	SRSF1_HUMAN	Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)	SRSF1 ASF SF2 SF2P33 SFRS1 OK/SW-cl.3	Homo sapiens (Human)	248	FUNCTION: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}.	MISCELLANEOUS: [Isoform ASF-3]: May be due to intron retention. {ECO:0000305}.	alternative mRNA splicing, via spliceosome [GO:0000380]; liver regeneration [GO:0097421]; mRNA 5'-splice site recognition [GO:0000395]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; oligodendrocyte differentiation [GO:0048709]; positive regulation of RNA splicing [GO:0033120]; regulation of RNA splicing [GO:0043484]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA topoisomerase binding [GO:0044547]; mRNA binding [GO:0003729]; protein kinase B binding [GO:0043422]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA topoisomerase binding [GO:0044547]; mRNA binding [GO:0003729]; protein kinase B binding [GO:0043422]; RNA binding [GO:0003723]; alternative mRNA splicing, via spliceosome [GO:0000380]; liver regeneration [GO:0097421]; mRNA 5'-splice site recognition [GO:0000395]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; oligodendrocyte differentiation [GO:0048709]; positive regulation of RNA splicing [GO:0033120]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12215544, ECO:0000269|PubMed:20308322, ECO:0000269|PubMed:24449914, ECO:0000269|PubMed:9420331}. Nucleus speckle {ECO:0000269|PubMed:12215544, ECO:0000269|PubMed:20308322, ECO:0000269|PubMed:24449914, ECO:0000269|PubMed:24644279, ECO:0000269|PubMed:9420331}. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm (PubMed:12215544, PubMed:20308322, PubMed:9420331, PubMed:24449914). Nuclear import is mediated via interaction with TNPO3 (PubMed:24449914). {ECO:0000269|PubMed:12215544, ECO:0000269|PubMed:20308322, ECO:0000269|PubMed:24449914, ECO:0000269|PubMed:9420331}.
Q07960	reviewed	RHG01_HUMAN	Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP)	ARHGAP1 CDC42GAP RHOGAP1	Homo sapiens (Human)	439	FUNCTION: GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.		endosomal transport [GO:0016197]; negative regulation of endocytic recycling [GO:2001136]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; small GTPase mediated signal transduction [GO:0007264]; transferrin transport [GO:0033572]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]	cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]; endosomal transport [GO:0016197]; negative regulation of endocytic recycling [GO:2001136]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; small GTPase mediated signal transduction [GO:0007264]; transferrin transport [GO:0033572]	SUBCELLULAR LOCATION: Cytoplasm.
Q07973	reviewed	CP24A_HUMAN	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24)	CYP24A1 CYP24	Homo sapiens (Human)	514	FUNCTION: A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:24893882, PubMed:15574355, PubMed:8679605, PubMed:11012668, PubMed:16617161, PubMed:29461981). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid (PubMed:24893882, PubMed:15574355). With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product (PubMed:11012668, PubMed:8679605). Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol (PubMed:25727742). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:8679605). {ECO:0000269|PubMed:11012668, ECO:0000269|PubMed:15574355, ECO:0000269|PubMed:16617161, ECO:0000269|PubMed:24893882, ECO:0000269|PubMed:25727742, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8679605}.	MISCELLANEOUS: [Isoform 3]: Specifically expressed in macrophages. Lacks the transit peptide. May be a dominant negative-acting isoform possibly by sequestering vitamin D metabolites. {ECO:0000305}.	osteoblast differentiation [GO:0001649]; response to vitamin D [GO:0033280]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; vitamin D receptor signaling pathway [GO:0070561]; vitamin metabolic process [GO:0006766]	mitochondrial inner membrane [GO:0005743]	1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity [GO:0062181]; 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity [GO:0030342]; 25-hydroxycholecalciferol-23-hydroxylase activity [GO:0062180]; 25-hydroxycholecalciferol-24-hydroxylase activity [GO:0008403]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; vitamin D 25-hydroxylase activity [GO:0070643]	mitochondrial inner membrane [GO:0005743]; 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity [GO:0062181]; 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity [GO:0030342]; 25-hydroxycholecalciferol-23-hydroxylase activity [GO:0062180]; 25-hydroxycholecalciferol-24-hydroxylase activity [GO:0008403]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; vitamin D 25-hydroxylase activity [GO:0070643]; osteoblast differentiation [GO:0001649]; response to vitamin D [GO:0033280]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; vitamin D receptor signaling pathway [GO:0070561]; vitamin metabolic process [GO:0006766]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q09128}.
Q08043	reviewed	ACTN3_HUMAN	Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)	ACTN3	Homo sapiens (Human)	901	FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.		actin cytoskeleton organization [GO:0030036]; bone morphogenesis [GO:0060349]; focal adhesion assembly [GO:0048041]; muscle cell development [GO:0055001]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of glycolytic process [GO:0045820]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of relaxation of muscle [GO:1901078]; positive regulation of bone mineralization involved in bone maturation [GO:1900159]; positive regulation of fast-twitch skeletal muscle fiber contraction [GO:0031448]; positive regulation of glucose catabolic process to lactate via pyruvate [GO:1904025]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of skeletal muscle tissue growth [GO:0048633]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of the force of skeletal muscle contraction [GO:0014728]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; skeletal muscle atrophy [GO:0014732]; transition between fast and slow fiber [GO:0014883]	actin filament [GO:0005884]; brush border [GO:0005903]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; structural constituent of muscle [GO:0008307]; transmembrane transporter binding [GO:0044325]	actin filament [GO:0005884]; brush border [GO:0005903]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; structural constituent of muscle [GO:0008307]; transmembrane transporter binding [GO:0044325]; actin cytoskeleton organization [GO:0030036]; bone morphogenesis [GO:0060349]; focal adhesion assembly [GO:0048041]; muscle cell development [GO:0055001]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of glycolytic process [GO:0045820]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of relaxation of muscle [GO:1901078]; positive regulation of bone mineralization involved in bone maturation [GO:1900159]; positive regulation of fast-twitch skeletal muscle fiber contraction [GO:0031448]; positive regulation of glucose catabolic process to lactate via pyruvate [GO:1904025]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of skeletal muscle tissue growth [GO:0048633]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of the force of skeletal muscle contraction [GO:0014728]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; skeletal muscle atrophy [GO:0014732]; transition between fast and slow fiber [GO:0014883]	
Q08050	reviewed	FOXM1_HUMAN	Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells)	FOXM1 FKHL16 HFH11 MPP2 WIN	Homo sapiens (Human)	763	FUNCTION: Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}.		DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; DNA repair [GO:0006281]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; regulation of Ras protein signal transduction [GO:0046578]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein kinase binding [GO:0019901]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein kinase binding [GO:0019901]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; DNA repair [GO:0006281]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; regulation of Ras protein signal transduction [GO:0046578]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q08116	reviewed	RGS1_HUMAN	Regulator of G-protein signaling 1 (RGS1) (B-cell activation protein BL34) (Early response protein 1R20)	RGS1 1R20 BL34 IER1	Homo sapiens (Human)	209	FUNCTION: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541). {ECO:0000250|UniProtKB:Q9JL25, ECO:0000269|PubMed:10480894, ECO:0000269|PubMed:18434541}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; leukotriene signaling pathway [GO:0061737]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; response to bacterium [GO:0009617]; signal transduction [GO:0007165]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]; G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; leukotriene signaling pathway [GO:0061737]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; response to bacterium [GO:0009617]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10480894}; Peripheral membrane protein {ECO:0000269|PubMed:10480894}; Cytoplasmic side {ECO:0000269|PubMed:10480894}. Cytoplasm, cytosol {ECO:0000269|PubMed:10480894}.
Q08117	reviewed	TLE5_HUMAN	TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)	TLE5 AES GRG GRG5	Homo sapiens (Human)	197	FUNCTION: Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. {ECO:0000269|PubMed:10660609, ECO:0000269|PubMed:10748198}.		cellular response to extracellular stimulus [GO:0031668]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of protein binding [GO:0032091]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of anoikis [GO:2000210]; regulation of growth [GO:0040008]; response to interleukin-1 [GO:0070555]; skeletal system development [GO:0001501]; Wnt signaling pathway [GO:0016055]	nucleus [GO:0005634]	identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]; cellular response to extracellular stimulus [GO:0031668]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of protein binding [GO:0032091]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of anoikis [GO:2000210]; regulation of growth [GO:0040008]; response to interleukin-1 [GO:0070555]; skeletal system development [GO:0001501]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q08170	reviewed	SRSF4_HUMAN	Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)	SRSF4 SFRS4 SRP75	Homo sapiens (Human)	494	FUNCTION: Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}.		mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; response to insulin [GO:0032868]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; response to insulin [GO:0032868]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:14578391}.
Q08174	reviewed	PCDH1_HUMAN	Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42)	PCDH1	Homo sapiens (Human)	1060	FUNCTION: May be involved in cell-cell interaction processes and in cell adhesion.		cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	cell junction [GO:0030054]; cell-cell junction [GO:0005911]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	cell junction [GO:0030054]; cell-cell junction [GO:0005911]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell junction. Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.
Q08188	reviewed	TGM3_HUMAN	Protein-glutamine gamma-glutamyltransferase E (EC 2.3.2.13) (Transglutaminase E) (TG(E)) (TGE) (TGase E) (Transglutaminase-3) (TGase-3) [Cleaved into: Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain]	TGM3	Homo sapiens (Human)	693	FUNCTION: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. {ECO:0000250}.		hair follicle morphogenesis [GO:0031069]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; protein modification process [GO:0036211]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; protein-containing complex [GO:0032991]	acyltransferase activity [GO:0016746]; calcium ion binding [GO:0005509]; catalytic activity [GO:0003824]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; protein-containing complex [GO:0032991]; acyltransferase activity [GO:0016746]; calcium ion binding [GO:0005509]; catalytic activity [GO:0003824]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; structural molecule activity [GO:0005198]; hair follicle morphogenesis [GO:0031069]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27866708}.
Q08209	reviewed	PP2BA_HUMAN	Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform)	PPP3CA CALNA CNA	Homo sapiens (Human)	521	FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118). Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (PubMed:30718414). Negatively regulates SLC9A1 activity (PubMed:31375679). {ECO:0000250|UniProtKB:P48452, ECO:0000250|UniProtKB:P63328, ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:30254215, ECO:0000269|PubMed:30611118, ECO:0000269|PubMed:30718414, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:33691586}.	MISCELLANEOUS: Although African swine fever virus infects pigs and not humans, human PPP3CA has been used for the crystallization. PPP3CA interacts with African swine fever virus Mal-047/A238L (via PKIIIT and FLCVK motifs); the interaction does not block catalytic activity per se but inhibits PPP3CA function by blocking the access to the two substrate recognition sites. {ECO:0000269|PubMed:23468591}.	calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; calcium ion transport [GO:0006816]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to glucose stimulus [GO:0071333]; dendrite morphogenesis [GO:0048813]; dephosphorylation [GO:0016311]; epidermis development [GO:0008544]; excitatory postsynaptic potential [GO:0060079]; G1/S transition of mitotic cell cycle [GO:0000082]; keratinocyte differentiation [GO:0030216]; modulation of chemical synaptic transmission [GO:0050804]; multicellular organismal response to stress [GO:0033555]; negative regulation of angiotensin-activated signaling pathway [GO:0110062]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin secretion [GO:0046676]; negative regulation of signaling [GO:0023057]; peptidyl-serine dephosphorylation [GO:0070262]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endocytosis [GO:0045807]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerulus development [GO:0090193]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of saliva secretion [GO:0046878]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein dephosphorylation [GO:0006470]; protein import into nucleus [GO:0006606]; regulation of cell proliferation involved in kidney morphogenesis [GO:0061006]; renal filtration [GO:0097205]; response to amphetamine [GO:0001975]; response to calcium ion [GO:0051592]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue regeneration [GO:0043403]; T cell activation [GO:0042110]; transition between fast and slow fiber [GO:0014883]; wound healing [GO:0042060]	calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of plasma membrane [GO:0019897]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein serine/threonine phosphatase complex [GO:0008287]; sarcolemma [GO:0042383]; Schaffer collateral - CA1 synapse [GO:0098685]; slit diaphragm [GO:0036057]; Z disc [GO:0030018]	ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; cyclosporin A binding [GO:0016018]; enzyme binding [GO:0019899]; myosin phosphatase activity [GO:0017018]; protein dimerization activity [GO:0046983]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]	calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of plasma membrane [GO:0019897]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein serine/threonine phosphatase complex [GO:0008287]; sarcolemma [GO:0042383]; Schaffer collateral - CA1 synapse [GO:0098685]; slit diaphragm [GO:0036057]; Z disc [GO:0030018]; ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; cyclosporin A binding [GO:0016018]; enzyme binding [GO:0019899]; myosin phosphatase activity [GO:0017018]; protein dimerization activity [GO:0046983]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]; calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; calcium ion transport [GO:0006816]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to glucose stimulus [GO:0071333]; dendrite morphogenesis [GO:0048813]; dephosphorylation [GO:0016311]; epidermis development [GO:0008544]; excitatory postsynaptic potential [GO:0060079]; G1/S transition of mitotic cell cycle [GO:0000082]; keratinocyte differentiation [GO:0030216]; modulation of chemical synaptic transmission [GO:0050804]; multicellular organismal response to stress [GO:0033555]; negative regulation of angiotensin-activated signaling pathway [GO:0110062]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin secretion [GO:0046676]; negative regulation of signaling [GO:0023057]; peptidyl-serine dephosphorylation [GO:0070262]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endocytosis [GO:0045807]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerulus development [GO:0090193]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of saliva secretion [GO:0046878]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein dephosphorylation [GO:0006470]; protein import into nucleus [GO:0006606]; regulation of cell proliferation involved in kidney morphogenesis [GO:0061006]; renal filtration [GO:0097205]; response to amphetamine [GO:0001975]; response to calcium ion [GO:0051592]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue regeneration [GO:0043403]; T cell activation [GO:0042110]; transition between fast and slow fiber [GO:0014883]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722}. Cell membrane {ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:28881575}; Peripheral membrane protein {ECO:0000269|PubMed:22343722}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P63329}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:P63329}. Cell projection, dendritic spine {ECO:0000269|PubMed:22343722}. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca(2+)-channel activation (PubMed:22343722). {ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:22343722}.
Q08211	reviewed	DHX9_HUMAN	ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A)	DHX9 DDX9 LKP NDH2	Homo sapiens (Human)	1270	FUNCTION: Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:9111062, PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:25062910, PubMed:24990949, PubMed:28221134). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:9111062, PubMed:10198287). Binds also to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11149922, PubMed:9323138, PubMed:9662397, PubMed:11038348, PubMed:11416126, PubMed:15355351, PubMed:28221134). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Acts also as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:9162007, PubMed:10924507, PubMed:11402034). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:9892698, PubMed:11096080). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}.		alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to tumor necrosis factor [GO:0071356]; CRD-mediated mRNA stabilization [GO:0070934]; DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; DNA-templated transcription termination [GO:0006353]; DNA-templated viral transcription [GO:0039695]; G-quadruplex DNA unwinding [GO:0044806]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA transport [GO:0051028]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; osteoblast differentiation [GO:0001649]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of polysome binding [GO:1905698]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of viral transcription [GO:0050434]; positive regulation of viral translation [GO:1904973]; protein localization to cytoplasmic stress granule [GO:1903608]; protein-containing complex assembly [GO:0065003]; pyroptosis [GO:0070269]; regulation of cytoplasmic translation [GO:2000765]; regulation of defense response to virus by host [GO:0050691]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]	actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; polysomal ribosome [GO:0042788]; polysome [GO:0005844]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' DNA/RNA helicase activity [GO:0033679]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; importin-alpha family protein binding [GO:0061676]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; nucleoside triphosphate diphosphatase activity [GO:0047429]; polysome binding [GO:1905538]; promoter-specific chromatin binding [GO:1990841]; regulatory region RNA binding [GO:0001069]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase binding [GO:0070063]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; triplex DNA binding [GO:0045142]	actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; polysomal ribosome [GO:0042788]; polysome [GO:0005844]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]; 3'-5' DNA helicase activity [GO:0043138]; 3'-5' DNA/RNA helicase activity [GO:0033679]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; importin-alpha family protein binding [GO:0061676]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; nucleoside triphosphate diphosphatase activity [GO:0047429]; polysome binding [GO:1905538]; promoter-specific chromatin binding [GO:1990841]; regulatory region RNA binding [GO:0001069]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase binding [GO:0070063]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; triplex DNA binding [GO:0045142]; alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to tumor necrosis factor [GO:0071356]; CRD-mediated mRNA stabilization [GO:0070934]; DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; DNA-templated transcription termination [GO:0006353]; DNA-templated viral transcription [GO:0039695]; G-quadruplex DNA unwinding [GO:0044806]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA transport [GO:0051028]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; osteoblast differentiation [GO:0001649]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of polysome binding [GO:1905698]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of viral transcription [GO:0050434]; positive regulation of viral translation [GO:1904973]; protein localization to cytoplasmic stress granule [GO:1903608]; protein-containing complex assembly [GO:0065003]; pyroptosis [GO:0070269]; regulation of cytoplasmic translation [GO:2000765]; regulation of defense response to virus by host [GO:0050691]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:16375861, ECO:0000269|PubMed:17303075, ECO:0000269|PubMed:9162007}. Nucleus, nucleoplasm {ECO:0000269|PubMed:28221134}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Cytoplasm {ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:16375861, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:8690889, ECO:0000269|PubMed:9162007}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:17498979}. Note=Nucleoplasmic shuttling protein (PubMed:10198287, PubMed:16375861, PubMed:10207077, PubMed:9162007). Its nuclear import involves the nucleocytoplasmic transport receptor Importin alpha/Importin beta receptor pathway in a Ran-dependent manner (PubMed:16375861). In interphase, localizes in nuclear stress granules and at perichromatin fibrils and in cytoplasmic ribonucleoprotein granules (PubMed:10198287). Colocalizes with WRN and H2AX at centrosomes in a microtubule-dependent manner following DNA damaging agent treatment (PubMed:17498979). Excluded from the mitotic nucleus as early as prophase and re-entered the nucleus at telophase (PubMed:10198287). Recruited in diffuse and discrete intranuclear foci (GLFG-body) in a NUP98-dependent manner (PubMed:28221134). Colocalizes with SP7 in the nucleus (PubMed:17303075). Colocalizes with ACTB at nuclear actin filaments inside the nucleus or at the nuclear pore (PubMed:11687588). Colocalizes with HNRNPC at nuclear ribonucleoprotein complex proteins in the nucleus (PubMed:11687588). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). {ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:16375861, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:17303075, ECO:0000269|PubMed:17498979, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:9162007}.
Q08257	reviewed	QOR_HUMAN	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin)	CRYZ	Homo sapiens (Human)	329	FUNCTION: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. {ECO:0000269|PubMed:17497241, ECO:0000269|PubMed:20103721}.		protein homotetramerization [GO:0051289]; visual perception [GO:0007601]; xenobiotic catabolic process [GO:0042178]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; NADPH binding [GO:0070402]; NADPH:quinone reductase activity [GO:0003960]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; NADPH binding [GO:0070402]; NADPH:quinone reductase activity [GO:0003960]; zinc ion binding [GO:0008270]; protein homotetramerization [GO:0051289]; visual perception [GO:0007601]; xenobiotic catabolic process [GO:0042178]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20103721}.
Q08289	reviewed	CACB2_HUMAN	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB)	CACNB2 CACNLB2 MYSB	Homo sapiens (Human)	660	FUNCTION: Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). {ECO:0000250|UniProtKB:Q8CC27, ECO:0000250|UniProtKB:Q8VGC3, ECO:0000269|PubMed:17525370, ECO:0000269|PubMed:36424916}.		calcium ion import [GO:0070509]; chemical synaptic transmission [GO:0007268]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; neuromuscular junction development [GO:0007528]; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904879]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of high voltage-gated calcium channel activity [GO:1901843]; protein localization to plasma membrane [GO:0072659]; regulation of heart rate by cardiac conduction [GO:0086091]; visual perception [GO:0007601]	L-type voltage-gated calcium channel complex [GO:1990454]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; voltage-gated calcium channel complex [GO:0005891]	actin filament binding [GO:0051015]; calcium channel activity [GO:0005262]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626]	L-type voltage-gated calcium channel complex [GO:1990454]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; voltage-gated calcium channel complex [GO:0005891]; actin filament binding [GO:0051015]; calcium channel activity [GO:0005262]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626]; calcium ion import [GO:0070509]; chemical synaptic transmission [GO:0007268]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; neuromuscular junction development [GO:0007528]; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904879]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of high voltage-gated calcium channel activity [GO:1901843]; protein localization to plasma membrane [GO:0072659]; regulation of heart rate by cardiac conduction [GO:0086091]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Q08334	reviewed	I10R2_HUMAN	Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)	IL10RB CRFB4 D21S58 D21S66	Homo sapiens (Human)	325	FUNCTION: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:15123776}.		cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cellular respiration [GO:1901857]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; signal transduction [GO:0007165]; type III interferon-mediated signaling pathway [GO:0038196]	interleukin-28 receptor complex [GO:0032002]; membrane [GO:0016020]; plasma membrane [GO:0005886]	interleukin-10 receptor activity [GO:0004920]; signaling receptor activity [GO:0038023]	interleukin-28 receptor complex [GO:0032002]; membrane [GO:0016020]; plasma membrane [GO:0005886]; interleukin-10 receptor activity [GO:0004920]; signaling receptor activity [GO:0038023]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cellular respiration [GO:1901857]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; signal transduction [GO:0007165]; type III interferon-mediated signaling pathway [GO:0038196]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q08345	reviewed	DDR1_HUMAN	Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)	DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	Homo sapiens (Human)	913	FUNCTION: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. {ECO:0000250, ECO:0000269|PubMed:12065315, ECO:0000269|PubMed:16234985, ECO:0000269|PubMed:16337946, ECO:0000269|PubMed:19401332, ECO:0000269|PubMed:20093046, ECO:0000269|PubMed:20432435, ECO:0000269|PubMed:20884741, ECO:0000269|PubMed:21044884, ECO:0000269|PubMed:9659899}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	axon development [GO:0061564]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; ear development [GO:0043583]; embryo implantation [GO:0007566]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of cell population proliferation [GO:0008285]; neuron projection extension [GO:1990138]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; regulation of cell growth [GO:0001558]; regulation of cell-matrix adhesion [GO:0001952]; regulation of extracellular matrix disassembly [GO:0010715]; smooth muscle cell migration [GO:0014909]; smooth muscle cell-matrix adhesion [GO:0061302]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; wound healing, spreading of cells [GO:0044319]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; collagen binding [GO:0005518]; metal ion binding [GO:0046872]; protein tyrosine kinase collagen receptor activity [GO:0038062]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; collagen binding [GO:0005518]; metal ion binding [GO:0046872]; protein tyrosine kinase collagen receptor activity [GO:0038062]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; axon development [GO:0061564]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; ear development [GO:0043583]; embryo implantation [GO:0007566]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of cell population proliferation [GO:0008285]; neuron projection extension [GO:1990138]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; regulation of cell growth [GO:0001558]; regulation of cell-matrix adhesion [GO:0001952]; regulation of extracellular matrix disassembly [GO:0010715]; smooth muscle cell migration [GO:0014909]; smooth muscle cell-matrix adhesion [GO:0061302]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.
Q08357	reviewed	S20A2_HUMAN	Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2)	SLC20A2 GLVR2 PIT2	Homo sapiens (Human)	652	FUNCTION: Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}.		monoatomic ion transport [GO:0006811]; phosphate ion transmembrane transport [GO:0035435]; positive regulation of bone mineralization [GO:0030501]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	inorganic phosphate transmembrane transporter activity [GO:0005315]; signaling receptor activity [GO:0038023]; sodium:phosphate symporter activity [GO:0005436]; virus receptor activity [GO:0001618]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; inorganic phosphate transmembrane transporter activity [GO:0005315]; signaling receptor activity [GO:0038023]; sodium:phosphate symporter activity [GO:0005436]; virus receptor activity [GO:0001618]; monoatomic ion transport [GO:0006811]; phosphate ion transmembrane transport [GO:0035435]; positive regulation of bone mineralization [GO:0030501]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756, ECO:0000269|PubMed:9151850}; Multi-pass membrane protein {ECO:0000269|PubMed:9151850}. Apical cell membrane {ECO:0000250|UniProtKB:Q63488}; Multi-pass membrane protein {ECO:0000255}.
Q08378	reviewed	GOGA3_HUMAN	Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160)	GOLGA3	Homo sapiens (Human)	1498	FUNCTION: Golgi auto-antigen; probably involved in maintaining Golgi structure.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.		cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	cadherin binding [GO:0045296]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; cadherin binding [GO:0045296]	SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
Q08379	reviewed	GOGA2_HUMAN	Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95)	GOLGA2	Homo sapiens (Human)	1002	FUNCTION: Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). {ECO:0000250|UniProtKB:Q62839, ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26165940, ECO:0000305|PubMed:26363069}.		asymmetric cell division [GO:0008356]; centrosome cycle [GO:0007098]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi disassembly [GO:0090166]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; meiotic spindle assembly [GO:0090306]; microtubule nucleation [GO:0007020]; mitotic spindle assembly [GO:0090307]; negative regulation of autophagy [GO:0010507]; negative regulation of protein binding [GO:0032091]; positive regulation of protein glycosylation [GO:0060050]; protein glycosylation [GO:0006486]; protein homotetramerization [GO:0051289]; protein transport [GO:0015031]; spindle assembly [GO:0051225]	cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; syntaxin binding [GO:0019905]	cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; syntaxin binding [GO:0019905]; asymmetric cell division [GO:0008356]; centrosome cycle [GO:0007098]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi disassembly [GO:0090166]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; meiotic spindle assembly [GO:0090306]; microtubule nucleation [GO:0007020]; mitotic spindle assembly [GO:0090307]; negative regulation of autophagy [GO:0010507]; negative regulation of protein binding [GO:0032091]; positive regulation of protein glycosylation [GO:0060050]; protein glycosylation [GO:0006486]; protein homotetramerization [GO:0051289]; protein transport [GO:0015031]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:11781572, ECO:0000305|PubMed:8315394}; Peripheral membrane protein {ECO:0000269|PubMed:11781572}; Cytoplasmic side {ECO:0000269|PubMed:11781572}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:11781572}; Peripheral membrane protein {ECO:0000269|PubMed:11781572}; Cytoplasmic side {ECO:0000269|PubMed:11781572}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:26165940}. Note=Associates with the mitotic spindle during mitosis (PubMed:26165940). {ECO:0000250|UniProtKB:Q62839, ECO:0000269|PubMed:26165940}.
Q08380	reviewed	LG3BP_HUMAN	Galectin-3-binding protein (Basement membrane autoantigen p105) (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (MAC2BP) (Mac-2 BP) (Tumor-associated antigen 90K)	LGALS3BP M2BP	Homo sapiens (Human)	585	FUNCTION: Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells. {ECO:0000269|PubMed:11146440, ECO:0000269|PubMed:8034587, ECO:0000269|PubMed:9501082}.		cell adhesion [GO:0007155]; cellular defense response [GO:0006968]; signal transduction [GO:0007165]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet dense granule lumen [GO:0031089]	scavenger receptor activity [GO:0005044]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet dense granule lumen [GO:0031089]; scavenger receptor activity [GO:0005044]; cell adhesion [GO:0007155]; cellular defense response [GO:0006968]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8390986}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:9501082}.
Q08397	reviewed	LOXL1_HUMAN	Lysyl oxidase homolog 1 (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL)	LOXL1 LOXL	Homo sapiens (Human)	574	FUNCTION: Active on elastin and collagen substrates. {ECO:0000250}.		aorta development [GO:0035904]; collagen fibril organization [GO:0030199]; protein deamination [GO:0018277]; response to lipopolysaccharide [GO:0032496]	acrosomal vesicle [GO:0001669]; basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	copper ion binding [GO:0005507]; protein-lysine 6-oxidase activity [GO:0004720]	acrosomal vesicle [GO:0001669]; basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; copper ion binding [GO:0005507]; protein-lysine 6-oxidase activity [GO:0004720]; aorta development [GO:0035904]; collagen fibril organization [GO:0030199]; protein deamination [GO:0018277]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000305}.
Q08426	reviewed	ECHP_HUMAN	Peroxisomal bifunctional enzyme (PBE) (PBFE) (L-bifunctional protein) (LBP) (Multifunctional enzyme 1) (MFE1) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]	EHHADH ECHD	Homo sapiens (Human)	723	FUNCTION: Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long chain fatty acids peroxisomal beta-oxidation pathway (By similarity). Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (By similarity). Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species (Probable). Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (By similarity). With HSD17B4, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (PubMed:15060085). Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (By similarity). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (PubMed:15060085). {ECO:0000250|UniProtKB:P07896, ECO:0000250|UniProtKB:Q9DBM2, ECO:0000269|PubMed:15060085, ECO:0000305|PubMed:15060085}.	MISCELLANEOUS: Absent in patients suffering with peroxisomal disorders such as Zellweger syndrome, neonatal adrenoleukodystrophy and infantile Refsum disease.	fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; enoyl-CoA hydratase activity [GO:0004300]; enzyme binding [GO:0019899]; intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; enoyl-CoA hydratase activity [GO:0004300]; enzyme binding [GO:0019899]; intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000305}.
Q08431	reviewed	MFGM_HUMAN	Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin]	MFGE8	Homo sapiens (Human)	387	FUNCTION: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. {ECO:0000250, ECO:0000269|PubMed:19204935}.; FUNCTION: [Medin]: Main constituent of aortic medial amyloid. {ECO:0000269|PubMed:19204935}.	MISCELLANEOUS: [Isoform 2]: It is unsure whether Met-1 or an upstream Met is the initiator as the upstream Met corresponds to polymorphism rs1879326. {ECO:0000305}.	angiogenesis [GO:0001525]; apoptotic cell clearance [GO:0043277]; cell adhesion [GO:0007155]; single fertilization [GO:0007338]	acrosomal membrane [GO:0002080]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]	integrin binding [GO:0005178]; phosphatidylserine binding [GO:0001786]	acrosomal membrane [GO:0002080]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; integrin binding [GO:0005178]; phosphatidylserine binding [GO:0001786]; angiogenesis [GO:0001525]; apoptotic cell clearance [GO:0043277]; cell adhesion [GO:0007155]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:19204935}; Peripheral membrane protein {ECO:0000269|PubMed:19204935}. Secreted {ECO:0000269|PubMed:19204935}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P79385}; Peripheral membrane protein {ECO:0000250|UniProtKB:P79385}. Note=Located in the acrosomal region of zona-pellucida bound sperm. {ECO:0000250|UniProtKB:P79385}.
Q08462	reviewed	ADCY2_HUMAN	Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2)	ADCY2 KIAA1060	Homo sapiens (Human)	1091	FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). {ECO:0000250|UniProtKB:P26769, ECO:0000269|PubMed:15385642}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cAMP biosynthetic process [GO:0006171]; cAMP-mediated signaling [GO:0019933]; cellular response to forskolin [GO:1904322]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	adenylate cyclase activity [GO:0004016]; adenylate cyclase binding [GO:0008179]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; adenylate cyclase activity [GO:0004016]; adenylate cyclase binding [GO:0008179]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cAMP biosynthetic process [GO:0006171]; cAMP-mediated signaling [GO:0019933]; cellular response to forskolin [GO:1904322]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15385642}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:11549699, ECO:0000269|PubMed:21228062}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:11549699}.
Q08477	reviewed	CP4F3_HUMAN	Cytochrome P450 4F3 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYPIVF3) (Cytochrome P450-LTB-omega) (Docosahexaenoic acid omega-hydroxylase CYP4F3) (EC 1.14.14.79) (Leukotriene-B(4) 20-monooxygenase 2) (Leukotriene-B(4) omega-hydroxylase 2) (EC 1.14.14.94)	CYP4F3 LTB4H	Homo sapiens (Human)	520	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:8486631, PubMed:9675028, PubMed:11461919, PubMed:15145985, PubMed:16547005, PubMed:16820285, PubMed:18182499, PubMed:18065749, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:9675028). May play a role in inactivation of pro-inflammatory and anti-inflammatory oxylipins during the resolution of inflammation (PubMed:8486631, PubMed:9675028, PubMed:11461919, PubMed:15145985, PubMed:15364545, PubMed:16547005, PubMed:16820285, PubMed:18182499, PubMed:18065749, PubMed:18577768). {ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:15364545, ECO:0000269|PubMed:16547005, ECO:0000269|PubMed:16820285, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:8486631, ECO:0000269|PubMed:9675028}.; FUNCTION: [Isoform CYP4F3A]: Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of oxylipins in myeloid cells, displaying higher affinity for arachidonate metabolite leukotriene B4 (LTB4) (PubMed:8486631, PubMed:9675028, PubMed:11461919, PubMed:15364545). Inactivates LTB4 via three successive oxidative transformations to 20-hydroxy-LTB4, then to 20-oxo-LTB4 and to 20-carboxy-LTB4 (PubMed:9675028). Has omega-hydroxylase activity toward long-chain fatty acid epoxides with preference for 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate (EET) and 9,10-epoxyoctadecanoate (PubMed:15145985). Omega-hydroxylates monohydroxy polyunsaturated fatty acids (PUFAs), including hydroxyeicosatetraenoates (HETEs) and hydroxyeicosapentaenoates (HEPEs), to dihydroxy compounds (PubMed:15364545, PubMed:9675028). Contributes to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Has low hydroxylase activity toward PUFAs (PubMed:18577768, PubMed:11461919). {ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:15364545, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:8486631, ECO:0000269|PubMed:9675028}.; FUNCTION: [Isoform CYP4F3B]: Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of polyunsaturated fatty acids (PUFAs) (PubMed:11461919, PubMed:16820285, PubMed:18577768). Participates in the conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:11461919, PubMed:16820285, PubMed:18577768). Has high omega-hydroxylase activity toward other PUFAs, including eicosatrienoic acid (ETA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (PubMed:16820285, PubMed:18577768). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of PUFAs with lower efficiency (PubMed:18577768). Contributes to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid and hexacosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acids, thereby initiating chain shortening (PubMed:16547005, PubMed:18182499). Omega-hydroxylates long-chain 3-hydroxy fatty acids, likely initiating the oxidative conversion to the corresponding 3-hydroxydicarboxylic fatty acids (PubMed:18065749). Has omega-hydroxylase activity toward long-chain fatty acid epoxides with preference for 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate (EET) and 9,10-epoxyoctadecanoate (PubMed:15145985). {ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:16547005, ECO:0000269|PubMed:16820285, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:18577768}.		arachidonic acid metabolic process [GO:0019369]; fatty acid omega-oxidation [GO:0010430]; icosanoid metabolic process [GO:0006690]; leukotriene B4 catabolic process [GO:0036101]; leukotriene metabolic process [GO:0006691]; lipoxin A4 metabolic process [GO:2001302]; lipoxin B4 metabolic process [GO:2001304]; omega-hydroxylase P450 pathway [GO:0097267]	endoplasmic reticulum membrane [GO:0005789]	20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259]; 20-hydroxy-leukotriene B4 omega oxidase activity [GO:0097258]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; long-chain fatty acid omega-1 hydroxylase activity [GO:0120319]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; very long-chain fatty acid omega-hydroxylase activity [GO:0140692]	endoplasmic reticulum membrane [GO:0005789]; 20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259]; 20-hydroxy-leukotriene B4 omega oxidase activity [GO:0097258]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; long-chain fatty acid omega-1 hydroxylase activity [GO:0120319]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; very long-chain fatty acid omega-hydroxylase activity [GO:0140692]; arachidonic acid metabolic process [GO:0019369]; fatty acid omega-oxidation [GO:0010430]; icosanoid metabolic process [GO:0006690]; leukotriene B4 catabolic process [GO:0036101]; leukotriene metabolic process [GO:0006691]; lipoxin A4 metabolic process [GO:2001302]; lipoxin B4 metabolic process [GO:2001304]; omega-hydroxylase P450 pathway [GO:0097267]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:10409674}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000305|PubMed:10409674}; Single-pass membrane protein {ECO:0000255}.
Q08493	reviewed	PDE4C_HUMAN	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.53) (DPDE1) (PDE21)	PDE4C DPDE1	Homo sapiens (Human)	712	FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:7843419}.		cAMP catabolic process [GO:0006198]; signal transduction [GO:0007165]	cilium [GO:0005929]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]	cilium [GO:0005929]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]; cAMP catabolic process [GO:0006198]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q3UEI1}.
Q08495	reviewed	DEMA_HUMAN	Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9)	DMTN DMT EPB49	Homo sapiens (Human)	405	FUNCTION: Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}.		actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament capping [GO:0051693]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cytoskeleton organization [GO:0007010]; erythrocyte development [GO:0048821]; lamellipodium assembly [GO:0030032]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of blood coagulation [GO:0030194]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of wound healing [GO:0090303]; protein-containing complex assembly [GO:0065003]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of filopodium assembly [GO:0051489]; regulation of lamellipodium assembly [GO:0010591]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell projection membrane [GO:0031253]; cortical cytoskeleton [GO:0030863]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; postsynaptic density [GO:0014069]; spectrin-associated cytoskeleton [GO:0014731]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; protein self-association [GO:0043621]; signaling receptor binding [GO:0005102]; spectrin binding [GO:0030507]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell projection membrane [GO:0031253]; cortical cytoskeleton [GO:0030863]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; postsynaptic density [GO:0014069]; spectrin-associated cytoskeleton [GO:0014731]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; protein self-association [GO:0043621]; signaling receptor binding [GO:0005102]; spectrin binding [GO:0030507]; actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament capping [GO:0051693]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cytoskeleton organization [GO:0007010]; erythrocyte development [GO:0048821]; lamellipodium assembly [GO:0030032]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of blood coagulation [GO:0030194]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of wound healing [GO:0090303]; protein-containing complex assembly [GO:0065003]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of filopodium assembly [GO:0051489]; regulation of lamellipodium assembly [GO:0010591]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton. Cell membrane. Membrane {ECO:0000250}. Endomembrane system. Cell projection {ECO:0000250}. Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuole in malaria-infected erythrocytes at late stages of plasmodium berghei or falciparum development.
Q08499	reviewed	PDE4D_HUMAN	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43)	PDE4D DPDE3	Homo sapiens (Human)	809	FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}.	MISCELLANEOUS: [Isoform 3]: Activated by phosphorylation at Ser-53. Mutagenesis of Ser-54 abolishes activation. {ECO:0000305}.	adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate [GO:0086024]; adrenergic receptor signaling pathway [GO:0071875]; cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to epinephrine stimulus [GO:0071872]; establishment of endothelial barrier [GO:0061028]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of heart contraction [GO:0045822]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of relaxation of cardiac muscle [GO:1901898]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of type II interferon production [GO:0032729]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of signaling receptor activity [GO:0010469]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]	apical plasma membrane [GO:0016324]; calcium channel complex [GO:0034704]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; ATPase binding [GO:0051117]; beta-2 adrenergic receptor binding [GO:0031698]; cAMP binding [GO:0030552]; enzyme binding [GO:0019899]; heterocyclic compound binding [GO:1901363]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]	apical plasma membrane [GO:0016324]; calcium channel complex [GO:0034704]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; ATPase binding [GO:0051117]; beta-2 adrenergic receptor binding [GO:0031698]; cAMP binding [GO:0030552]; enzyme binding [GO:0019899]; heterocyclic compound binding [GO:1901363]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]; adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate [GO:0086024]; adrenergic receptor signaling pathway [GO:0071875]; cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to epinephrine stimulus [GO:0071872]; establishment of endothelial barrier [GO:0061028]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of heart contraction [GO:0045822]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of relaxation of cardiac muscle [GO:1901898]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of type II interferon production [GO:0032729]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of signaling receptor activity [GO:0010469]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:14500724}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells. {ECO:0000250}.
Q08554	reviewed	DSC1_HUMAN	Desmocollin-1 (Cadherin family member 1) (Desmosomal glycoprotein 2/3) (DG2/DG3)	DSC1 CDHF1	Homo sapiens (Human)	894	FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.		cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	cornified envelope [GO:0001533]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; gap junction [GO:0005921]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	cornified envelope [GO:0001533]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; gap junction [GO:0005921]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Q08623	reviewed	HDHD1_HUMAN	Pseudouridine-5'-phosphatase (EC 3.1.3.96) (Haloacid dehalogenase-like hydrolase domain-containing protein 1) (Haloacid dehalogenase-like hydrolase domain-containing protein 1A) (Protein GS1) (Pseudouridine-5'-monophosphatase) (5'-PsiMPase)	PUDP DXF68S1E FAM16AX GS1 HDHD1 HDHD1A	Homo sapiens (Human)	228	FUNCTION: Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine. {ECO:0000269|PubMed:20722631}.		nucleotide metabolic process [GO:0009117]	cytosol [GO:0005829]	metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; pseudouridine 5'-phosphatase activity [GO:1990738]	cytosol [GO:0005829]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; pseudouridine 5'-phosphatase activity [GO:1990738]; nucleotide metabolic process [GO:0009117]	
Q08629	reviewed	TICN1_HUMAN	Testican-1 (Protein SPOCK)	SPOCK1 SPOCK TIC1 TICN1	Homo sapiens (Human)	439	FUNCTION: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.		cell adhesion [GO:0007155]; central nervous system neuron differentiation [GO:0021953]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; regulation of cell growth [GO:0001558]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; node of Ranvier [GO:0033268]; postsynaptic density [GO:0014069]; sarcoplasm [GO:0016528]	calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; node of Ranvier [GO:0033268]; postsynaptic density [GO:0014069]; sarcoplasm [GO:0016528]; calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867]; cell adhesion [GO:0007155]; central nervous system neuron differentiation [GO:0021953]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; regulation of cell growth [GO:0001558]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q08648	reviewed	SG11B_HUMAN	Sperm-associated antigen 11B (Human epididymis-specific protein 2) (He2) (Protein EP2) (Sperm antigen HE2)	SPAG11B EP2 HE2	Homo sapiens (Human)	103	FUNCTION: Has antimicrobial activity against E.coli (By similarity). Plays a role in the defense response in the male reproductive tract, contributing to sperm maturation, storage and protection (By similarity). {ECO:0000250|UniProtKB:Q8VBV2}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytolysis by host of symbiont cells [GO:0051838]; defense response to bacterium [GO:0042742]; spermatogenesis [GO:0007283]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytolysis by host of symbiont cells [GO:0051838]; defense response to bacterium [GO:0042742]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q08708	reviewed	CLM6_HUMAN	CMRF35-like molecule 6 (CLM-6) (CD300 antigen-like family member C) (CMRF35-A1) (CMRF-35) (Immunoglobulin superfamily member 16) (IgSF16) (CD antigen CD300c)	CD300C CMRF35 CMRF35A CMRF35A1 IGSF16	Homo sapiens (Human)	224			cellular defense response [GO:0006968]; immune system process [GO:0002376]	plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; cellular defense response [GO:0006968]; immune system process [GO:0002376]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q08722	reviewed	CD47_HUMAN	Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)	CD47 MER6	Homo sapiens (Human)	323	FUNCTION: Adhesive protein that mediates cell-to-cell interactions (PubMed:11509594, PubMed:15383453). Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:19004835, PubMed:8550562, PubMed:7691831). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:27742621, PubMed:19004835, PubMed:8550562, PubMed:11509594, PubMed:7691831, PubMed:32679764, PubMed:15383453). Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (PubMed:11509594). Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (PubMed:15383453). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764). In response to THBS1, negatively modulates wound healing (By similarity). Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction (PubMed:7691831). May prevent premature elimination of red blood cells (By similarity). {ECO:0000250|UniProtKB:P97829, ECO:0000250|UniProtKB:Q61735, ECO:0000269|PubMed:11509594, ECO:0000269|PubMed:15383453, ECO:0000269|PubMed:19004835, ECO:0000269|PubMed:27742621, ECO:0000269|PubMed:32679764, ECO:0000269|PubMed:7691831, ECO:0000269|PubMed:8550562}.		angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; ATP export [GO:1904669]; cell migration [GO:0016477]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-12 [GO:0071349]; cellular response to type II interferon [GO:0071346]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905450]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of inflammatory response [GO:0050729]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of phagocytosis [GO:0050766]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of T cell activation [GO:0050870]; regulation of interleukin-10 production [GO:0032653]; regulation of interleukin-12 production [GO:0032655]; regulation of interleukin-6 production [GO:0032675]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of tumor necrosis factor production [GO:0032680]; regulation of type II interferon production [GO:0032649]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	cell-cell adhesion mediator activity [GO:0098632]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; thrombospondin receptor activity [GO:0070053]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; cell-cell adhesion mediator activity [GO:0098632]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; thrombospondin receptor activity [GO:0070053]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; ATP export [GO:1904669]; cell migration [GO:0016477]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-12 [GO:0071349]; cellular response to type II interferon [GO:0071346]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905450]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of inflammatory response [GO:0050729]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of phagocytosis [GO:0050766]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of T cell activation [GO:0050870]; regulation of interleukin-10 production [GO:0032653]; regulation of interleukin-12 production [GO:0032655]; regulation of interleukin-6 production [GO:0032675]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of tumor necrosis factor production [GO:0032680]; regulation of type II interferon production [GO:0032649]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7691831}; Multi-pass membrane protein {ECO:0000269|PubMed:7691831}.
Q08752	reviewed	PPID_HUMAN	Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D)	PPID CYP40 CYPD	Homo sapiens (Human)	370	FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:18708059, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22681779, ECO:0000269|PubMed:23220213, ECO:0000269|PubMed:9659917}.; FUNCTION: (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release. {ECO:0000269|PubMed:19932913, ECO:0000269|PubMed:21711559}.		apoptotic process [GO:0006915]; cellular response to UV-A [GO:0071492]; chaperone-mediated protein folding [GO:0061077]; lipid droplet organization [GO:0034389]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein secretion [GO:0050714]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; viral release from host cell [GO:0019076]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclosporin A binding [GO:0016018]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; nuclear estrogen receptor binding [GO:0030331]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; transcription factor binding [GO:0008134]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclosporin A binding [GO:0016018]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; nuclear estrogen receptor binding [GO:0030331]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; transcription factor binding [GO:0008134]; apoptotic process [GO:0006915]; cellular response to UV-A [GO:0071492]; chaperone-mediated protein folding [GO:0061077]; lipid droplet organization [GO:0034389]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein secretion [GO:0050714]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11525244, ECO:0000269|PubMed:18708059}. Nucleus, nucleolus {ECO:0000269|PubMed:11525244, ECO:0000269|PubMed:18708059}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11525244, ECO:0000269|PubMed:18708059}.
Q08828	reviewed	ADCY1_HUMAN	Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase)	ADCY1	Homo sapiens (Human)	1119	FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). {ECO:0000250|UniProtKB:O88444, ECO:0000250|UniProtKB:P19754}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; axonogenesis [GO:0007409]; cAMP biosynthetic process [GO:0006171]; cAMP-mediated signaling [GO:0019933]; cellular response to calcium ion [GO:0071277]; cellular response to forskolin [GO:1904322]; circadian rhythm [GO:0007623]; long-term memory [GO:0007616]; neuroinflammatory response [GO:0150076]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of long-term synaptic potentiation [GO:1900273]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of circadian rhythm [GO:0042752]; response to xenobiotic stimulus [GO:0009410]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; axonogenesis [GO:0007409]; cAMP biosynthetic process [GO:0006171]; cAMP-mediated signaling [GO:0019933]; cellular response to calcium ion [GO:0071277]; cellular response to forskolin [GO:1904322]; circadian rhythm [GO:0007623]; long-term memory [GO:0007616]; neuroinflammatory response [GO:0150076]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of long-term synaptic potentiation [GO:1900273]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of circadian rhythm [GO:0042752]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P19754}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19754}. Cell membrane {ECO:0000269|PubMed:11549699}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:O88444}. Membrane raft {ECO:0000250|UniProtKB:P19754}. Note=Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia. {ECO:0000250|UniProtKB:O88444}.
Q08830	reviewed	FGL1_HUMAN	Fibrinogen-like protein 1 (HP-041) (Hepassocin) (HPS) (Hepatocyte-derived fibrinogen-related protein 1) (HFREP-1) (Liver fibrinogen-related protein 1) (LFIRE-1)	FGL1 HFREP1	Homo sapiens (Human)	312	FUNCTION: Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967). {ECO:0000269|PubMed:11470158, ECO:0000269|PubMed:19880967, ECO:0000269|PubMed:30580966}.		adaptive immune response [GO:0002250]; cell-matrix adhesion [GO:0007160]; hepatocyte proliferation [GO:0072574]; negative regulation of T cell activation [GO:0050868]; platelet aggregation [GO:0070527]; regulation of immune response [GO:0050776]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]	signaling receptor binding [GO:0005102]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; signaling receptor binding [GO:0005102]; adaptive immune response [GO:0002250]; cell-matrix adhesion [GO:0007160]; hepatocyte proliferation [GO:0072574]; negative regulation of T cell activation [GO:0050868]; platelet aggregation [GO:0070527]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11470158, ECO:0000269|PubMed:30580966}. Note=Secreted in the blood plasma. {ECO:0000269|PubMed:30580966}.
Q08881	reviewed	ITK_HUMAN	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)	ITK EMT LYK	Homo sapiens (Human)	620	FUNCTION: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}.		activation of phospholipase C activity [GO:0007202]; adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; cellular defense response [GO:0006968]; gamma-delta T cell activation [GO:0046629]; intracellular signal transduction [GO:0035556]; NK T cell differentiation [GO:0001865]; phosphorylation [GO:0016310]; positive regulation of cytokine production [GO:0001819]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]	cell-cell junction [GO:0005911]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]	cell-cell junction [GO:0005911]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; activation of phospholipase C activity [GO:0007202]; adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; cellular defense response [GO:0006968]; gamma-delta T cell activation [GO:0046629]; intracellular signal transduction [GO:0035556]; NK T cell differentiation [GO:0001865]; phosphorylation [GO:0016310]; positive regulation of cytokine production [GO:0001819]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17060314}. Nucleus {ECO:0000250|UniProtKB:Q03526}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.
Q08945	reviewed	SSRP1_HUMAN	FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160)	SSRP1 FACT80	Homo sapiens (Human)	709	FUNCTION: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}.	MISCELLANEOUS: Autoantibodies against SSRP1 are present in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases.	DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; regulation of chromatin organization [GO:1902275]	FACT complex [GO:0035101]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]	FACT complex [GO:0035101]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; regulation of chromatin organization [GO:1902275]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10421373, ECO:0000269|PubMed:22002106}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106}. Chromosome {ECO:0000269|PubMed:10421373}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci. {ECO:0000250|UniProtKB:Q05344}.
Q08999	reviewed	RBL2_HUMAN	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)	RBL2 RB2	Homo sapiens (Human)	1139	FUNCTION: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.		cell cycle [GO:0007049]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; regulation of lipid kinase activity [GO:0043550]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	promoter-specific chromatin binding [GO:1990841]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; regulation of lipid kinase activity [GO:0043550]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q08AD1	reviewed	CAMP2_HUMAN	Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)	CAMSAP2 CAMSAP1L1 KIAA1078	Homo sapiens (Human)	1489	FUNCTION: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}.		axon development [GO:0061564]; cytoplasmic microtubule organization [GO:0031122]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of dendrite development [GO:0050773]; regulation of Golgi organization [GO:1903358]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle organization [GO:0033043]	ciliary basal body [GO:0036064]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule end [GO:1990752]	calmodulin binding [GO:0005516]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507]	ciliary basal body [GO:0036064]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule end [GO:1990752]; calmodulin binding [GO:0005516]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507]; axon development [GO:0061564]; cytoplasmic microtubule organization [GO:0031122]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of dendrite development [GO:0050773]; regulation of Golgi organization [GO:1903358]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle organization [GO:0033043]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570}. Golgi apparatus {ECO:0000269|PubMed:27666745}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8C1B1}. Cytoplasm {ECO:0000250|UniProtKB:Q8C1B1}. Note=Associated with the minus-end of microtubules and also detected at the centrosomes (PubMed:23169647, PubMed:24486153, PubMed:24908486, PubMed:24706919, PubMed:27666745, PubMed:28814570). Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound (PubMed:24486153). The length of CAMSAP2-decorated stretches on the minus-end of microtubules depends on MAPRE1/EB1 and MAPRE3/EB3, which promote elongation of CAMSAP2-decorated microtubule stretches (PubMed:28814570). Recruited to the Golgi apparatus by AKAP9 and PDE4DIP isoform 13/MMG8/SMYLE (PubMed:27666745). In neurons, localizes to the minus-end of microtubules in axon and dendrites (PubMed:24908486). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570}.
Q08AE8	reviewed	SPIR1_HUMAN	Protein spire homolog 1 (Spir-1)	SPIRE1 KIAA1135 SPIR1	Homo sapiens (Human)	756	FUNCTION: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}.		actin cytoskeleton organization [GO:0030036]; actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; Golgi vesicle transport [GO:0048193]; innate immune response [GO:0045087]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of mitochondrial fission [GO:0090141]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	actin binding [GO:0003779]	cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; actin cytoskeleton organization [GO:0030036]; actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; Golgi vesicle transport [GO:0048193]; innate immune response [GO:0045087]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of mitochondrial fission [GO:0090141]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11747823}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11747823}. Cell membrane {ECO:0000269|PubMed:11747823}; Peripheral membrane protein {ECO:0000269|PubMed:11747823}; Cytoplasmic side {ECO:0000269|PubMed:11747823}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q52KF3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q52KF3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q52KF3}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11 (By similarity). {ECO:0000250|UniProtKB:Q52KF3}.
Q08AF8	reviewed	GOG8F_HUMAN	Putative golgin subfamily A member 8F/8G	GOLGA8F; GOLGA8G	Homo sapiens (Human)	430			Golgi organization [GO:0007030]; spindle assembly [GO:0051225]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]; spindle assembly [GO:0051225]	
Q08AG5	reviewed	ZN844_HUMAN	Zinc finger protein 844	ZNF844	Homo sapiens (Human)	666	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q08AG7	reviewed	MZT1_HUMAN	Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1)	MZT1 C13orf37 MOZART1	Homo sapiens (Human)	82	FUNCTION: Required for gamma-tubulin complex recruitment to the centrosome. {ECO:0000269|PubMed:20360068}.		gamma-tubulin complex localization [GO:0033566]; microtubule nucleation by interphase microtubule organizing center [GO:0051415]; mitotic spindle assembly [GO:0090307]	centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; interphase microtubule organizing center [GO:0031021]; spindle [GO:0005819]		centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; interphase microtubule organizing center [GO:0031021]; spindle [GO:0005819]; gamma-tubulin complex localization [GO:0033566]; microtubule nucleation by interphase microtubule organizing center [GO:0051415]; mitotic spindle assembly [GO:0090307]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20360068}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20360068}.
Q08AH1	reviewed	ACSM1_HUMAN	Acyl-coenzyme A synthetase ACSM1, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 1) (Benzoate--CoA ligase) (EC 6.2.1.25) (Butyrate--CoA ligase 1) (Butyryl-coenzyme A synthetase 1) (Lipoate-activating enzyme) (Middle-chain acyl-CoA synthetase 1) (Xenobiotic/medium-chain fatty acid-CoA ligase HXM-B)	ACSM1 BUCS1 LAE MACS1	Homo sapiens (Human)	577	FUNCTION: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10434065). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (By similarity). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity). {ECO:0000250|UniProtKB:Q9BEA2, ECO:0000269|PubMed:10434065}.		acyl-CoA metabolic process [GO:0006637]; benzoate metabolic process [GO:0018874]; butyrate metabolic process [GO:0019605]; cholesterol homeostasis [GO:0042632]; energy derivation by oxidation of organic compounds [GO:0015980]; fatty acid biosynthetic process [GO:0006633]; fatty acid oxidation [GO:0019395]; xenobiotic metabolic process [GO:0006805]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]	ATP binding [GO:0005524]; benzoate-CoA ligase activity [GO:0018858]; butyrate-CoA ligase activity [GO:0047760]; CoA-ligase activity [GO:0016405]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; GTP binding [GO:0005525]; long-chain fatty acid-CoA ligase activity [GO:0004467]; metal ion binding [GO:0046872]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; ATP binding [GO:0005524]; benzoate-CoA ligase activity [GO:0018858]; butyrate-CoA ligase activity [GO:0047760]; CoA-ligase activity [GO:0016405]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; GTP binding [GO:0005525]; long-chain fatty acid-CoA ligase activity [GO:0004467]; metal ion binding [GO:0046872]; acyl-CoA metabolic process [GO:0006637]; benzoate metabolic process [GO:0018874]; butyrate metabolic process [GO:0019605]; cholesterol homeostasis [GO:0042632]; energy derivation by oxidation of organic compounds [GO:0015980]; fatty acid biosynthetic process [GO:0006633]; fatty acid oxidation [GO:0019395]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q91VA0}. Mitochondrion {ECO:0000250|UniProtKB:Q91VA0}.
Q08AH3	reviewed	ACS2A_HUMAN	Acyl-coenzyme A synthetase ACSM2A, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 2A) (Benzoate--CoA ligase) (EC 6.2.1.25) (Butyrate--CoA ligase 2A) (Butyryl-coenzyme A synthetase 2A) (Middle-chain acyl-CoA synthetase 2A)	ACSM2A ACSM2 MACS2	Homo sapiens (Human)	577	FUNCTION: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity). {ECO:0000250|UniProtKB:Q68CK6}.		acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; glucose homeostasis [GO:0042593]; medium-chain fatty-acyl-CoA metabolic process [GO:0036112]; triglyceride homeostasis [GO:0070328]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; benzoate-CoA ligase activity [GO:0018858]; butyrate-CoA ligase activity [GO:0047760]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; metal ion binding [GO:0046872]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; benzoate-CoA ligase activity [GO:0018858]; butyrate-CoA ligase activity [GO:0047760]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; metal ion binding [GO:0046872]; acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; glucose homeostasis [GO:0042593]; medium-chain fatty-acyl-CoA metabolic process [GO:0036112]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q68CK6}.
Q08AM6	reviewed	VAC14_HUMAN	Protein VAC14 homolog (Tax1-binding protein 2)	VAC14 TAX1BP2 TRX	Homo sapiens (Human)	782	FUNCTION: Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:33098764). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:33098764}.		phosphatidylinositol biosynthetic process [GO:0006661]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; signal transduction [GO:0007165]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; PAS complex [GO:0070772]; presynaptic endosome [GO:0098830]	identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; PAS complex [GO:0070772]; presynaptic endosome [GO:0098830]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; phosphatidylinositol biosynthetic process [GO:0006661]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371}. Microsome membrane {ECO:0000250|UniProtKB:Q80W92}. Note=Mainly associated with membranes of the late endocytic pathway.
Q08ET2	reviewed	SIG14_HUMAN	Sialic acid-binding Ig-like lectin 14 (Siglec-14)	SIGLEC14 UNQ294/PRO333	Homo sapiens (Human)	396	FUNCTION: Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. {ECO:0000269|PubMed:17012248}.		cell adhesion [GO:0007155]	ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]	ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17012248}; Single-pass type I membrane protein {ECO:0000269|PubMed:17012248}.
Q08J23	reviewed	NSUN2_HUMAN	RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4)	NSUN2 SAKI TRM4	Homo sapiens (Human)	767	FUNCTION: RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31358969, PubMed:31199786). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}.		cell division [GO:0051301]; hair follicle maturation [GO:0048820]; in utero embryonic development [GO:0001701]; meiotic cell cycle checkpoint signaling [GO:0033313]; mRNA methylation [GO:0080009]; regulation of mRNA export from nucleus [GO:0010793]; regulation of stem cell differentiation [GO:2000736]; spermatid development [GO:0007286]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA stabilization [GO:0036416]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	mRNA (cytidine-5-)-methyltransferase activity [GO:0062152]; RNA binding [GO:0003723]; tRNA (cytosine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; mRNA (cytidine-5-)-methyltransferase activity [GO:0062152]; RNA binding [GO:0003723]; tRNA (cytosine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]; cell division [GO:0051301]; hair follicle maturation [GO:0048820]; in utero embryonic development [GO:0001701]; meiotic cell cycle checkpoint signaling [GO:0033313]; mRNA methylation [GO:0080009]; regulation of mRNA export from nucleus [GO:0010793]; regulation of stem cell differentiation [GO:2000736]; spermatid development [GO:0007286]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA stabilization [GO:0036416]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:17215513, ECO:0000269|PubMed:31276587}. Cytoplasm {ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:31276587}. Mitochondrion {ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31287866}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19596847}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:Q1HFZ0}. Note=Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA (PubMed:19596847). In testis, localizes to the chromatoid body (By similarity). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:19596847}.
Q09013	reviewed	DMPK_HUMAN	Myotonin-protein kinase (MT-PK) (EC 2.7.11.1) (DM-kinase) (DMK) (DM1 protein kinase) (DMPK) (Myotonic dystrophy protein kinase)	DMPK DM1PK MDPK	Homo sapiens (Human)	629	FUNCTION: Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. {ECO:0000269|PubMed:10811636, ECO:0000269|PubMed:10913253, ECO:0000269|PubMed:11287000, ECO:0000269|PubMed:15598648, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949239}.		intracellular calcium ion homeostasis [GO:0006874]; muscle cell apoptotic process [GO:0010657]; nuclear envelope organization [GO:0006998]; protein phosphorylation [GO:0006468]; regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction [GO:0014853]; regulation of heart contraction [GO:0008016]; regulation of myotube differentiation [GO:0010830]; regulation of skeletal muscle contraction by calcium ion signaling [GO:0014722]; regulation of sodium ion transport [GO:0002028]; regulation of synapse structural plasticity [GO:0051823]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; sarcoplasmic reticulum membrane [GO:0033017]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; myosin phosphatase regulator activity [GO:0017020]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; sarcoplasmic reticulum membrane [GO:0033017]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; myosin phosphatase regulator activity [GO:0017020]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular calcium ion homeostasis [GO:0006874]; muscle cell apoptotic process [GO:0010657]; nuclear envelope organization [GO:0006998]; protein phosphorylation [GO:0006468]; regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction [GO:0014853]; regulation of heart contraction [GO:0008016]; regulation of myotube differentiation [GO:0010830]; regulation of skeletal muscle contraction by calcium ion signaling [GO:0014722]; regulation of sodium ion transport [GO:0002028]; regulation of synapse structural plasticity [GO:0051823]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus outer membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Mitochondrion outer membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Sarcoplasmic reticulum membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Localizes to sarcoplasmic reticulum membranes of cardiomyocytes. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion membrane.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion membrane.
Q09028	reviewed	RBBP4_HUMAN	Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)	RBBP4 RBAP48	Homo sapiens (Human)	425	FUNCTION: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.		brain development [GO:0007420]; cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of cell fate specification [GO:0042659]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]	ATPase complex [GO:1904949]; CAF-1 complex [GO:0033186]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; NURF complex [GO:0016589]; protein-containing complex [GO:0032991]; Sin3 complex [GO:0016580]	histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	ATPase complex [GO:1904949]; CAF-1 complex [GO:0033186]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; NURF complex [GO:0016589]; protein-containing complex [GO:0032991]; Sin3 complex [GO:0016580]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; brain development [GO:0007420]; cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of cell fate specification [GO:0042659]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10220405, ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:33283408, ECO:0000269|PubMed:8858152}. Chromosome, telomere {ECO:0000269|PubMed:30045876}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:29499137}.
Q09161	reviewed	NCBP1_HUMAN	Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit)	NCBP1 CBP80 NCBP	Homo sapiens (Human)	790	FUNCTION: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (PubMed:26382858). {ECO:0000269|PubMed:11551508, ECO:0000269|PubMed:12093754, ECO:0000269|PubMed:15059963, ECO:0000269|PubMed:15361857, ECO:0000269|PubMed:16186820, ECO:0000269|PubMed:16317009, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17873884, ECO:0000269|PubMed:18369367, ECO:0000269|PubMed:19632182, ECO:0000269|PubMed:19648179, ECO:0000269|PubMed:26382858, ECO:0000269|PubMed:7651522, ECO:0000269|PubMed:8069914}.		7-methylguanosine mRNA capping [GO:0006370]; alternative mRNA splicing, via spliceosome [GO:0000380]; cap-dependent translational initiation [GO:0002191]; defense response to virus [GO:0051607]; histone mRNA metabolic process [GO:0008334]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA metabolic process [GO:0016071]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription by RNA polymerase II [GO:0042789]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cell growth [GO:0030307]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of RNA binding [GO:1905216]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; primary miRNA processing [GO:0031053]; regulation of mRNA processing [GO:0050684]; regulation of translational initiation [GO:0006446]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RNA catabolic process [GO:0006401]; RNA splicing [GO:0008380]; snRNA export from nucleus [GO:0006408]; spliceosomal complex assembly [GO:0000245]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; mRNA cap binding complex [GO:0005845]; nuclear cap binding complex [GO:0005846]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA cap binding complex [GO:0034518]	molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; mRNA cap binding complex [GO:0005845]; nuclear cap binding complex [GO:0005846]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA cap binding complex [GO:0034518]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; 7-methylguanosine mRNA capping [GO:0006370]; alternative mRNA splicing, via spliceosome [GO:0000380]; cap-dependent translational initiation [GO:0002191]; defense response to virus [GO:0051607]; histone mRNA metabolic process [GO:0008334]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA metabolic process [GO:0016071]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription by RNA polymerase II [GO:0042789]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cell growth [GO:0030307]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of RNA binding [GO:1905216]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; primary miRNA processing [GO:0031053]; regulation of mRNA processing [GO:0050684]; regulation of translational initiation [GO:0006446]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RNA catabolic process [GO:0006401]; RNA splicing [GO:0008380]; snRNA export from nucleus [GO:0006408]; spliceosomal complex assembly [GO:0000245]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19648179}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:17289661}.
Q09327	reviewed	MGAT3_HUMAN	Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.144) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III) (GNT-III) (GlcNAc-T III) (N-acetylglucosaminyltransferase III)	MGAT3 GGNT3	Homo sapiens (Human)	533	FUNCTION: It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate (PubMed:19403558). Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location (PubMed:19403558). Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation (PubMed:26801611). In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage (By similarity). {ECO:0000250|UniProtKB:Q10470, ECO:0000269|PubMed:19403558, ECO:0000269|PubMed:26801611}.		amyloid-beta metabolic process [GO:0050435]; cellular response to oxidative stress [GO:0034599]; cognition [GO:0050890]; N-acetylglucosamine metabolic process [GO:0006044]; negative regulation of lysosomal protein catabolic process [GO:1905166]; positive regulation of protein localization to early endosome [GO:1902966]; protein localization [GO:0008104]; protein N-linked glycosylation [GO:0006487]; regulation of cell migration [GO:0030334]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0003830]; glycosyltransferase activity [GO:0016757]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0003830]; glycosyltransferase activity [GO:0016757]; amyloid-beta metabolic process [GO:0050435]; cellular response to oxidative stress [GO:0034599]; cognition [GO:0050890]; N-acetylglucosamine metabolic process [GO:0006044]; negative regulation of lysosomal protein catabolic process [GO:1905166]; positive regulation of protein localization to early endosome [GO:1902966]; protein localization [GO:0008104]; protein N-linked glycosylation [GO:0006487]; regulation of cell migration [GO:0030334]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein {ECO:0000305}.
Q09328	reviewed	MGT5A_HUMAN	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.155) (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase V) (GlcNAc-T V) (GNT-V) (Mannoside acetylglucosaminyltransferase 5) (N-acetylglucosaminyl-transferase V) [Cleaved into: Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (Secreted beta-1,6-N-acetylglucosaminyltransferase V) (Secreted GNT-V)]	MGAT5 GGNT5	Homo sapiens (Human)	741	FUNCTION: Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:10395745, PubMed:30140003). Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2 (PubMed:10395745, PubMed:22614033, PubMed:30140003). Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration. MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling. Required for efficient interaction between TGFB1 and its receptor. Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF. MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways. Promotes cell migration. Contributes to the regulation of the inflammatory response. MGAT5-dependent TCR N-glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens. Required for normal leukocyte evasation and accumulation at sites of inflammation (By similarity). Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis (PubMed:22614033). {ECO:0000250|UniProtKB:Q8R4G6, ECO:0000269|PubMed:10395745, ECO:0000269|PubMed:22614033, ECO:0000269|PubMed:30140003}.; FUNCTION: [Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A]: Promotes proliferation of umbilical vein endothelial cells and angiogenesis, at least in part by promoting the release of the growth factor FGF2 from the extracellular matrix. {ECO:0000269|PubMed:11872751}.		negative regulation of protein tyrosine phosphatase activity [GO:1903614]; positive regulation of cell migration [GO:0030335]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; viral protein processing [GO:0019082]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity [GO:0030144]; manganese ion binding [GO:0030145]; protein phosphatase inhibitor activity [GO:0004864]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity [GO:0030144]; manganese ion binding [GO:0030145]; protein phosphatase inhibitor activity [GO:0004864]; negative regulation of protein tyrosine phosphatase activity [GO:1903614]; positive regulation of cell migration [GO:0030335]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:P97259}; Single-pass type II membrane protein {ECO:0000269|PubMed:17142794}.; SUBCELLULAR LOCATION: [Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A]: Secreted {ECO:0000269|PubMed:17142794}.
Q09428	reviewed	ABCC8_HUMAN	ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1)	ABCC8 HRINS SUR SUR1	Homo sapiens (Human)	1581	FUNCTION: Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. {ECO:0000269|PubMed:24814349, ECO:0000269|PubMed:25720052}.	MISCELLANEOUS: [Isoform 3]: Abundant isoform with prodiabetic properties, predominant in heart. {ECO:0000305}.	cellular response to organic substance [GO:0071310]; female pregnancy [GO:0007565]; glutamate secretion, neurotransmission [GO:0061535]; inorganic cation transmembrane transport [GO:0098662]; intracellular glucose homeostasis [GO:0001678]; memory [GO:0007613]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of insulin secretion [GO:0046676]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of neuroblast migration [GO:0061855]; neuromuscular process [GO:0050905]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of uterine smooth muscle relaxation [GO:1900721]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to pH [GO:0009268]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; transmembrane transport [GO:0055085]; visual learning [GO:0008542]	inward rectifying potassium channel [GO:0008282]; membrane [GO:0016020]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; sarcolemma [GO:0042383]; synaptic vesicle membrane [GO:0030672]	ABC-type transporter activity [GO:0140359]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; ATPase-coupled transmembrane transporter activity [GO:0042626]; potassium channel activity [GO:0005267]; protein-containing complex binding [GO:0044877]; sulfonylurea receptor activity [GO:0008281]; transmembrane transporter binding [GO:0044325]	inward rectifying potassium channel [GO:0008282]; membrane [GO:0016020]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; sarcolemma [GO:0042383]; synaptic vesicle membrane [GO:0030672]; ABC-type transporter activity [GO:0140359]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; ATPase-coupled transmembrane transporter activity [GO:0042626]; potassium channel activity [GO:0005267]; protein-containing complex binding [GO:0044877]; sulfonylurea receptor activity [GO:0008281]; transmembrane transporter binding [GO:0044325]; cellular response to organic substance [GO:0071310]; female pregnancy [GO:0007565]; glutamate secretion, neurotransmission [GO:0061535]; inorganic cation transmembrane transport [GO:0098662]; intracellular glucose homeostasis [GO:0001678]; memory [GO:0007613]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of insulin secretion [GO:0046676]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of neuroblast migration [GO:0061855]; neuromuscular process [GO:0050905]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of uterine smooth muscle relaxation [GO:1900721]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to pH [GO:0009268]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; transmembrane transport [GO:0055085]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24814349}; Multi-pass membrane protein {ECO:0000255}.
Q09470	reviewed	KCNA1_HUMAN	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated K(+) channel HuKI) (Voltage-gated potassium channel HBK1) (Voltage-gated potassium channel subunit Kv1.1)	KCNA1	Homo sapiens (Human)	495	FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:8845167, PubMed:19903818). Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:12077175, PubMed:17156368). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:19968958, PubMed:19307729, PubMed:19903818). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (By similarity). Required for normal neuromuscular responses (PubMed:11026449, PubMed:17136396). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed:23903368, PubMed:19307729). {ECO:0000250|UniProtKB:P10499, ECO:0000269|PubMed:11026449, ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:15837928, ECO:0000269|PubMed:17136396, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:19307729, ECO:0000269|PubMed:19903818, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:19968958, ECO:0000269|PubMed:21106501, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:8845167}.	MISCELLANEOUS: The delay or D-type current observed in hippocampus pyramidal neurons is probably mediated by potassium channels containing KCNA2 plus KCNA1 or other family members. It is activated at about -50 mV, i.e. below the action potential threshold, and is characterized by slow inactivation, extremely slow recovery from inactivation, sensitivity to dendrotoxin (DTX) and to 4-aminopyridine (4-AP). {ECO:0000305|PubMed:17917103}.	axon development [GO:0061564]; cell communication by electrical coupling [GO:0010644]; cellular response to magnesium ion [GO:0071286]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; hippocampus development [GO:0021766]; magnesium ion homeostasis [GO:0010960]; membrane repolarization during action potential [GO:0086011]; neuroblast proliferation [GO:0007405]; neuromuscular process [GO:0050905]; neuronal action potential [GO:0019228]; neuronal signal transduction [GO:0023041]; optic nerve development [GO:0021554]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; protein localization [GO:0008104]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of muscle contraction [GO:0006937]; startle response [GO:0001964]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; calyx of Held [GO:0044305]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; neuronal cell body [GO:0043025]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; disordered domain specific binding [GO:0097718]; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1905030]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; calyx of Held [GO:0044305]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; neuronal cell body [GO:0043025]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; disordered domain specific binding [GO:0097718]; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1905030]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]; axon development [GO:0061564]; cell communication by electrical coupling [GO:0010644]; cellular response to magnesium ion [GO:0071286]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; hippocampus development [GO:0021766]; magnesium ion homeostasis [GO:0010960]; membrane repolarization during action potential [GO:0086011]; neuroblast proliferation [GO:0007405]; neuromuscular process [GO:0050905]; neuronal action potential [GO:0019228]; neuronal signal transduction [GO:0023041]; optic nerve development [GO:0021554]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; protein localization [GO:0008104]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of muscle contraction [GO:0006937]; startle response [GO:0001964]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:15837928, ECO:0000269|PubMed:17136396, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:19307729, ECO:0000269|PubMed:19903818, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:19968958, ECO:0000269|PubMed:23903368}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:11086297}. Cell projection, axon {ECO:0000269|PubMed:11086297}. Cytoplasmic vesicle {ECO:0000269|PubMed:23774215}. Perikaryon {ECO:0000250|UniProtKB:P10499}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P10499}. Cell projection, dendrite {ECO:0000250|UniProtKB:P16388}. Cell junction {ECO:0000250|UniProtKB:P16388}. Synapse {ECO:0000250|UniProtKB:P16388}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P10499}. Presynapse {ECO:0000250|UniProtKB:P16388}. Note=Homotetrameric KCNA1 is primarily located in the endoplasmic reticulum. Interaction with KCNA2 and KCNAB2 or with KCNA4 and KCNAB2 promotes expression at the cell membrane (By similarity). {ECO:0000250|UniProtKB:P10499, ECO:0000250|UniProtKB:P16388}.
Q09472	reviewed	EP300_HUMAN	Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)	EP300 P300	Homo sapiens (Human)	2414	FUNCTION: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:12929931, PubMed:16762839, PubMed:18722353). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}.		animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; B cell differentiation [GO:0030183]; behavioral defense response [GO:0002209]; cell cycle [GO:0007049]; cellular response to leucine [GO:0071233]; cellular response to nutrient levels [GO:0031669]; cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; internal peptidyl-lysine acetylation [GO:0018393]; internal protein amino acid acetylation [GO:0006475]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; learning or memory [GO:0007611]; lung development [GO:0030324]; macrophage derived foam cell differentiation [GO:0010742]; megakaryocyte development [GO:0035855]; multicellular organism growth [GO:0035264]; N-terminal peptidyl-lysine acetylation [GO:0018076]; negative regulation of autophagy [GO:0010507]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; peptidyl-lysine acetylation [GO:0018394]; peptidyl-lysine butyrylation [GO:0140067]; peptidyl-lysine crotonylation [GO:0140066]; peptidyl-lysine propionylation [GO:0061921]; platelet formation [GO:0030220]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein acetylation [GO:0006473]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of autophagy [GO:0010506]; regulation of cellular response to heat [GO:1900034]; regulation of glycolytic process [GO:0006110]; regulation of mitochondrion organization [GO:0010821]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of tubulin deacetylation [GO:0090043]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; swimming [GO:0036268]; thigmotaxis [GO:0001966]; transcription by RNA polymerase II [GO:0006366]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]	acetyltransferase activity [GO:0016407]; acyltransferase activity [GO:0016746]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone butyryltransferase activity [GO:0140069]; histone crotonyltransferase activity [GO:0140068]; histone H2B acetyltransferase activity [GO:0044013]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H4 acetyltransferase activity [GO:0010485]; histone lactyltransferase activity [GO:0120301]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; NF-kappaB binding [GO:0051059]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; peptide 2-hydroxyisobutyryltransferase activity [GO:0106226]; peptide butyryltransferase activity [GO:0140065]; peptide N-acetyltransferase activity [GO:0034212]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; pre-mRNA intronic binding [GO:0097157]; protein propionyltransferase activity [GO:0061920]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; STAT family protein binding [GO:0097677]; tau protein binding [GO:0048156]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]; acetyltransferase activity [GO:0016407]; acyltransferase activity [GO:0016746]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone butyryltransferase activity [GO:0140069]; histone crotonyltransferase activity [GO:0140068]; histone H2B acetyltransferase activity [GO:0044013]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H4 acetyltransferase activity [GO:0010485]; histone lactyltransferase activity [GO:0120301]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; NF-kappaB binding [GO:0051059]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; peptide 2-hydroxyisobutyryltransferase activity [GO:0106226]; peptide butyryltransferase activity [GO:0140065]; peptide N-acetyltransferase activity [GO:0034212]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; pre-mRNA intronic binding [GO:0097157]; protein propionyltransferase activity [GO:0061920]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; STAT family protein binding [GO:0097677]; tau protein binding [GO:0048156]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; B cell differentiation [GO:0030183]; behavioral defense response [GO:0002209]; cell cycle [GO:0007049]; cellular response to leucine [GO:0071233]; cellular response to nutrient levels [GO:0031669]; cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; internal peptidyl-lysine acetylation [GO:0018393]; internal protein amino acid acetylation [GO:0006475]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; learning or memory [GO:0007611]; lung development [GO:0030324]; macrophage derived foam cell differentiation [GO:0010742]; megakaryocyte development [GO:0035855]; multicellular organism growth [GO:0035264]; N-terminal peptidyl-lysine acetylation [GO:0018076]; negative regulation of autophagy [GO:0010507]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; peptidyl-lysine acetylation [GO:0018394]; peptidyl-lysine butyrylation [GO:0140067]; peptidyl-lysine crotonylation [GO:0140066]; peptidyl-lysine propionylation [GO:0061921]; platelet formation [GO:0030220]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein acetylation [GO:0006473]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of autophagy [GO:0010506]; regulation of cellular response to heat [GO:1900034]; regulation of glycolytic process [GO:0006110]; regulation of mitochondrion organization [GO:0010821]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of tubulin deacetylation [GO:0090043]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; swimming [GO:0036268]; thigmotaxis [GO:0001966]; transcription by RNA polymerase II [GO:0006366]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:20940255}. Nucleus {ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:16219772, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:20940255, ECO:0000269|PubMed:25593309}. Chromosome {ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:25818647}. Note=Localizes to active chromatin: Colocalizes with histone H3 acetylated and/or crotonylated at 'Lys-18' (H3K18ac and H3K18cr, respectively) (PubMed:25818647). In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus (PubMed:12929931). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:25818647}.
Q09666	reviewed	AHNK_HUMAN	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	AHNAK PM227	Homo sapiens (Human)	5890	FUNCTION: May be required for neuronal cell differentiation.		positive regulation of plasma membrane repair [GO:1905686]; regulation of RNA splicing [GO:0043484]; regulation of voltage-gated calcium channel activity [GO:1901385]	actin cytoskeleton [GO:0015629]; cell-cell contact zone [GO:0044291]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; vesicle [GO:0031982]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548]; structural molecule activity conferring elasticity [GO:0097493]	actin cytoskeleton [GO:0015629]; cell-cell contact zone [GO:0044291]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548]; structural molecule activity conferring elasticity [GO:0097493]; positive regulation of plasma membrane repair [GO:1905686]; regulation of RNA splicing [GO:0043484]; regulation of voltage-gated calcium channel activity [GO:1901385]	SUBCELLULAR LOCATION: Nucleus.
Q09FC8	reviewed	ZN415_HUMAN	Zinc finger protein 415	ZNF415	Homo sapiens (Human)	603	FUNCTION: Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53. {ECO:0000269|PubMed:17055453}.		regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17055453}. Cytoplasm {ECO:0000269|PubMed:17055453}. Note=Isoforms 1, isoform 2, isoform 4 and isoform 5 showed both nuclear and cytoplasm localization. Isoform 3 localized only to nucleus.
Q0D2H9	reviewed	GOG8D_HUMAN	Putative golgin subfamily A member 8D	GOLGA8DP GOLGA8D	Homo sapiens (Human)	430			Golgi organization [GO:0007030]; spindle assembly [GO:0051225]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]; spindle assembly [GO:0051225]	
Q0D2I5	reviewed	IFFO1_HUMAN	Non-homologous end joining factor IFFO1 (NHEJ factor IFFO1) (Intermediate filament family orphan 1) (Tumor antigen HOM-TES-103)	IFFO1 IFFO	Homo sapiens (Human)	559	FUNCTION: Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). {ECO:0000269|PubMed:31548606}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	DNA double-strand break attachment to nuclear envelope [GO:1990683]; double-strand break repair via nonhomologous end joining [GO:0006303]; protein localization to site of double-strand break [GO:1990166]	intermediate filament [GO:0005882]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]		intermediate filament [GO:0005882]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; DNA double-strand break attachment to nuclear envelope [GO:1990683]; double-strand break repair via nonhomologous end joining [GO:0006303]; protein localization to site of double-strand break [GO:1990166]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31548606}. Nucleus, nucleoplasm {ECO:0000269|PubMed:31548606}. Nucleus inner membrane {ECO:0000269|PubMed:31548606}. Nucleus matrix {ECO:0000269|PubMed:31548606}. Note=Mainly soluble, the remaining is localized in the nuclear matrix (PubMed:31548606). Localized at double-strand break (DSB) sites near the lamina and nuclear matrix structures (PubMed:31548606). {ECO:0000269|PubMed:31548606}.
Q0D2K0	reviewed	NIPA4_HUMAN	Magnesium transporter NIPA4 (Ichthyin) (NIPA-like protein 4) (Non-imprinted in Prader-Willi/Angelman syndrome region protein 4)	NIPAL4 ICHN NIPA4	Homo sapiens (Human)	404	FUNCTION: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Sr(2+) and Fe(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway (PubMed:15317751). {ECO:0000250|UniProtKB:Q8BZF2, ECO:0000269|PubMed:15317751}.		magnesium ion transport [GO:0015693]	membrane [GO:0016020]	magnesium ion transmembrane transporter activity [GO:0015095]	membrane [GO:0016020]; magnesium ion transmembrane transporter activity [GO:0015095]; magnesium ion transport [GO:0015693]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9JJC8}; Multi-pass membrane protein {ECO:0000255}.
Q0D2K3	reviewed	RIPP1_HUMAN	Protein ripply1	RIPPLY1	Homo sapiens (Human)	151	FUNCTION: Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity). {ECO:0000250|UniProtKB:Q2WG80}.		embryonic pattern specification [GO:0009880]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; somite rostral/caudal axis specification [GO:0032525]; somite specification [GO:0001757]	nucleus [GO:0005634]		nucleus [GO:0005634]; embryonic pattern specification [GO:0009880]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; somite rostral/caudal axis specification [GO:0032525]; somite specification [GO:0001757]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2WG80}.
Q0GE19	reviewed	NTCP7_HUMAN	Sodium/bile acid cotransporter 7 (Na(+)/bile acid cotransporter 7) (Solute carrier family 10 member 7)	SLC10A7 C4orf13 P7 PSEC0051	Homo sapiens (Human)	340	FUNCTION: Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization (PubMed:30082715, PubMed:29878199). Also involved in the regulation of cellular calcium homeostasis (PubMed:30082715, PubMed:31191616). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate). {ECO:0000269|PubMed:17628207, ECO:0000269|PubMed:29878199, ECO:0000269|PubMed:30082715, ECO:0000269|PubMed:31191616}.		bone development [GO:0060348]; glycoprotein transport [GO:0034436]; Golgi vesicle transport [GO:0048193]; heparin biosynthetic process [GO:0030210]; intracellular calcium ion homeostasis [GO:0006874]; sodium ion transport [GO:0006814]	cis-Golgi network [GO:0005801]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	bile acid transmembrane transporter activity [GO:0015125]; symporter activity [GO:0015293]	cis-Golgi network [GO:0005801]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; bile acid transmembrane transporter activity [GO:0015125]; symporter activity [GO:0015293]; bone development [GO:0060348]; glycoprotein transport [GO:0034436]; Golgi vesicle transport [GO:0048193]; heparin biosynthetic process [GO:0030210]; intracellular calcium ion homeostasis [GO:0006874]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17628207, ECO:0000269|PubMed:30082715}; Multi-pass membrane protein {ECO:0000305|PubMed:17628207}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17628207}; Multi-pass membrane protein {ECO:0000305|PubMed:17628207}. Golgi apparatus membrane {ECO:0000269|PubMed:29878199}.
Q0IIM8	reviewed	TBC8B_HUMAN	TBC1 domain family member 8B	TBC1D8B	Homo sapiens (Human)	1120	FUNCTION: Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein. {ECO:0000269|PubMed:30661770}.		glomerular filtration [GO:0003094]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]	calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096]; glomerular filtration [GO:0003094]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:30661770}.
Q0JRZ9	reviewed	FCHO2_HUMAN	F-BAR domain only protein 2	FCHO2	Homo sapiens (Human)	810	FUNCTION: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.	MISCELLANEOUS: Deforms liposomes into a range of tubule diameters from 20 to 130 nm in vitro.	clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; membrane invagination [GO:0010324]; protein localization to plasma membrane [GO:0072659]; synaptic vesicle endocytosis [GO:0048488]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynaptic endocytic zone membrane [GO:0098835]	identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynaptic endocytic zone membrane [GO:0098835]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; membrane invagination [GO:0010324]; protein localization to plasma membrane [GO:0072659]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.
Q0P5N6	reviewed	ARL16_HUMAN	ADP-ribosylation factor-like protein 16	ARL16	Homo sapiens (Human)	197	FUNCTION: May suppress the RNA sensing activity of RIGI in a GTP-dependent. {ECO:0000269|PubMed:21233210}.			cytoplasm [GO:0005737]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21233210}.
Q0PNE2	reviewed	ELP6_HUMAN	Elongator complex protein 6 (Angiotonin-transactivated protein 1) (Protein TMEM103)	ELP6 ATP1 C3orf75 TMEM103	Homo sapiens (Human)	266	FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:22854966, PubMed:29332244). Involved in cell migration (By similarity). {ECO:0000250|UniProtKB:Q8BK75, ECO:0000269|PubMed:22854966, ECO:0000303|PubMed:29332244}.		positive regulation of cell migration [GO:0030335]; regulation of translation [GO:0006417]; tRNA wobble uridine modification [GO:0002098]	cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634]		cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634]; positive regulation of cell migration [GO:0030335]; regulation of translation [GO:0006417]; tRNA wobble uridine modification [GO:0002098]	
Q0VAK6	reviewed	LMOD3_HUMAN	Leiomodin-3 (Leiomodin, fetal form)	LMOD3	Homo sapiens (Human)	560	FUNCTION: Essential for the organization of sarcomeric actin thin filaments in skeletal muscle (PubMed:25250574). Increases the rate of actin polymerization (PubMed:25250574). {ECO:0000269|PubMed:25250574}.		actin filament organization [GO:0007015]; actin nucleation [GO:0045010]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of skeletal muscle fiber development [GO:0048743]; skeletal muscle fiber development [GO:0048741]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; M band [GO:0031430]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865]	actin monomer binding [GO:0003785]; tropomyosin binding [GO:0005523]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; M band [GO:0031430]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865]; actin monomer binding [GO:0003785]; tropomyosin binding [GO:0005523]; actin filament organization [GO:0007015]; actin nucleation [GO:0045010]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of skeletal muscle fiber development [GO:0048743]; skeletal muscle fiber development [GO:0048741]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25250574}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:25250574}. Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:E9QA62}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25250574}. Note=Highly expressed in nonstriated areas of developing myotubes, where it shows a granular cytoplasmic pattern. In sarcomeres, highly expressed in the M band region and, at lower levels, along actin thin filaments. Not detected in Z-disks. In sarcomeres, may be located near, but not at, actin thin filament pointed end. {ECO:0000269|PubMed:25250574}.
Q0VAM2	reviewed	RGF1B_HUMAN	Ras-GEF domain-containing family member 1B (GPI gamma-4)	RASGEF1B GPIG4	Homo sapiens (Human)	473	FUNCTION: Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro). {ECO:0000269|PubMed:19645719, ECO:0000269|PubMed:23894443}.		Ras protein signal transduction [GO:0007265]	early endosome [GO:0005769]; late endosome [GO:0005770]; midbody [GO:0030496]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	early endosome [GO:0005769]; late endosome [GO:0005770]; midbody [GO:0030496]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; Ras protein signal transduction [GO:0007265]	SUBCELLULAR LOCATION: Early endosome {ECO:0000250}. Late endosome {ECO:0000250}. Midbody {ECO:0000269|PubMed:23894443}. Note=May shuttle between early and late endosomes (By similarity). Localizes to midbody at telophase. {ECO:0000250}.
Q0VAQ4	reviewed	SMAGP_HUMAN	Small cell adhesion glycoprotein (Small transmembrane and glycosylated protein)	SMAGP	Homo sapiens (Human)	97	FUNCTION: May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation. {ECO:0000269|PubMed:15986429}.			cell junction [GO:0030054]; cytoplasmic vesicle membrane [GO:0030659]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		cell junction [GO:0030054]; cytoplasmic vesicle membrane [GO:0030659]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15021913}; Single-pass type III membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:15986429}; Single-pass type III membrane protein {ECO:0000255}. Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions (PubMed:15021913). Detected on cytoplasmic membranes in undifferentiated tumors (PubMed:15986429). {ECO:0000269|PubMed:15021913, ECO:0000269|PubMed:15986429}.
Q0VD83	reviewed	APOBR_HUMAN	Apolipoprotein B receptor (Apolipoprotein B-100 receptor) (Apolipoprotein B-48 receptor) (Apolipoprotein B48 receptor) (apoB-48R)	APOBR APOB48R	Homo sapiens (Human)	1097	FUNCTION: Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. {ECO:0000269|PubMed:10852956, ECO:0000269|PubMed:15591219, ECO:0000269|PubMed:9633939}.		cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869]; triglyceride metabolic process [GO:0006641]	chylomicron [GO:0042627]; low-density lipoprotein particle [GO:0034362]; membrane [GO:0016020]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361]	very-low-density lipoprotein particle receptor activity [GO:0030229]	chylomicron [GO:0042627]; low-density lipoprotein particle [GO:0034362]; membrane [GO:0016020]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361]; very-low-density lipoprotein particle receptor activity [GO:0030229]; cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10191299, ECO:0000269|PubMed:7619811}; Peripheral membrane protein {ECO:0000269|PubMed:10191299, ECO:0000269|PubMed:7619811}. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein.
Q0VD86	reviewed	INCA1_HUMAN	Protein INCA1 (Inhibitor of CDK interacting with cyclin A1)	INCA1 HSD45	Homo sapiens (Human)	236	FUNCTION: Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity). {ECO:0000250|UniProtKB:Q6PKN7, ECO:0000269|PubMed:21540187}.		apoptotic signaling pathway [GO:0097190]; fibroblast proliferation [GO:0048144]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of fibroblast proliferation [GO:0048147]; positive regulation of apoptotic signaling pathway [GO:2001235]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; apoptotic signaling pathway [GO:0097190]; fibroblast proliferation [GO:0048144]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of fibroblast proliferation [GO:0048147]; positive regulation of apoptotic signaling pathway [GO:2001235]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15159402, ECO:0000269|PubMed:18756329}. Cytoplasm {ECO:0000269|PubMed:18756329}.
Q0VDD7	reviewed	BRME1_HUMAN	Break repair meiotic recombinase recruitment factor 1 (Pre-T/NK cell-associated protein 3B3)	BRME1 C19orf57	Homo sapiens (Human)	668	FUNCTION: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. {ECO:0000250|UniProtKB:Q6DIA7}.		double-strand break repair involved in meiotic recombination [GO:1990918]; female meiosis I [GO:0007144]; spermatogenesis [GO:0007283]	chromosome [GO:0005694]		chromosome [GO:0005694]; double-strand break repair involved in meiotic recombination [GO:1990918]; female meiosis I [GO:0007144]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q6DIA7}. Note=During meiosis, recruited to chromosomes and localizes on recombination sites in a double-strand break-dependent manner. First appears on the chromosome axis at leptotene. Along with the progression of meiotic recombination, released from the axis to form bridge-like structures linking homolog axes before they are synapsed. Finally, located between synapsed homolog axes and on the synaptonemal complex (SC). {ECO:0000250|UniProtKB:Q6DIA7}.
Q0VDD8	reviewed	DYH14_HUMAN	Dynein axonemal heavy chain 14 (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14)	DNAH14 C1orf67	Homo sapiens (Human)	3507	FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.		cilium movement involved in cell motility [GO:0060294]	9+2 motile cilium [GO:0097729]; cytoplasm [GO:0005737]; dynein complex [GO:0030286]; microtubule [GO:0005874]	ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; cytoplasm [GO:0005737]; dynein complex [GO:0030286]; microtubule [GO:0005874]; ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; cilium movement involved in cell motility [GO:0060294]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}.
Q0VF96	reviewed	CGNL1_HUMAN	Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin)	CGNL1 JACOP KIAA1749	Homo sapiens (Human)	1302	FUNCTION: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}.		actin filament organization [GO:0007015]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of stress fiber assembly [GO:0051497]; protein localization to cell-cell junction [GO:0150105]	bicellular tight junction [GO:0005923]; myosin complex [GO:0016459]; protein-containing complex [GO:0032991]		bicellular tight junction [GO:0005923]; myosin complex [GO:0016459]; protein-containing complex [GO:0032991]; actin filament organization [GO:0007015]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of stress fiber assembly [GO:0051497]; protein localization to cell-cell junction [GO:0150105]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:Q6AW69}. Note=Localizes to the apical junction complex composed of tight and adherens junctions (PubMed:22891260). In the liver and kidney, it is also found along non-junctional actin filament bundles in addition to the apical junction (By similarity). {ECO:0000250|UniProtKB:Q6AW69, ECO:0000269|PubMed:22891260}.
Q0VG06	reviewed	FP100_HUMAN	Fanconi anemia core complex-associated protein 100 (Fanconi anemia-associated protein of 100 kDa)	FAAP100 C17orf70	Homo sapiens (Human)	881	FUNCTION: Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. {ECO:0000269|PubMed:17396147}.		interstrand cross-link repair [GO:0036297]	chromatin [GO:0000785]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]	chromatin [GO:0000785]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; interstrand cross-link repair [GO:0036297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17396147}.
Q0VG99	reviewed	MESP2_HUMAN	Mesoderm posterior protein 2 (Class C basic helix-loop-helix protein 6) (bHLHc6)	MESP2 BHLHC6 SCDO2	Homo sapiens (Human)	397	FUNCTION: Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.		heart morphogenesis [GO:0003007]; mesoderm formation [GO:0001707]; Notch signaling pathway [GO:0007219]; regulation of transcription by RNA polymerase II [GO:0006357]; somite rostral/caudal axis specification [GO:0032525]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; heart morphogenesis [GO:0003007]; mesoderm formation [GO:0001707]; Notch signaling pathway [GO:0007219]; regulation of transcription by RNA polymerase II [GO:0006357]; somite rostral/caudal axis specification [GO:0032525]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q0VGL1	reviewed	LTOR4_HUMAN	Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) [Cleaved into: Ragulator complex protein LAMTOR4, N-terminally processed]	LAMTOR4 C7orf59	Homo sapiens (Human)	99	FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:30181260, PubMed:29107538, PubMed:29158492, PubMed:28935770). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:30181260, PubMed:29107538, PubMed:29158492, PubMed:28935770). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:30181260, PubMed:29107538, PubMed:29158492, PubMed:28935770). {ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:30181260}.		cellular response to amino acid stimulus [GO:0071230]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization to lysosome [GO:0061462]; regulation of cell size [GO:0008361]; TORC1 signaling [GO:0038202]	FNIP-folliculin RagC/D GAP [GO:1990877]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; Ragulator complex [GO:0071986]		FNIP-folliculin RagC/D GAP [GO:1990877]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; Ragulator complex [GO:0071986]; cellular response to amino acid stimulus [GO:0071230]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization to lysosome [GO:0061462]; regulation of cell size [GO:0008361]; TORC1 signaling [GO:0038202]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:22980980}.
Q0WX57	reviewed	U17LO_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (EC 3.4.19.12) (Deubiquitinating enzyme 17) (Ubiquitin thioesterase 17) (Ubiquitin-specific-processing protease 17)	USP17L24 USP17 USP17H USP17I USP17J USP17K USP17L USP17M; USP17L25; USP17L26; USP17L27; USP17L28; USP17L29; USP17L30	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000269|PubMed:10936051}.		apoptotic process [GO:0006915]; positive regulation of epithelial cell apoptotic process [GO:1904037]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; hyaluronic acid binding [GO:0005540]; RNA binding [GO:0003723]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; hyaluronic acid binding [GO:0005540]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; positive regulation of epithelial cell apoptotic process [GO:1904037]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:17109758}. Endoplasmic reticulum {ECO:0000250}.
Q0ZGT2	reviewed	NEXN_HUMAN	Nexilin (F-actin-binding protein) (Nelin)	NEXN	Homo sapiens (Human)	675	FUNCTION: Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}.		axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; axon [GO:0030424]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; cell-cell adhesion mediator activity [GO:0098632]; structural constituent of muscle [GO:0008307]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; axon [GO:0030424]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; cell-cell adhesion mediator activity [GO:0098632]; structural constituent of muscle [GO:0008307]; axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Z2J4}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9Z2J4}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9Z2J4}. Note=Localizes to the cell-matrix AJ. Not found at the cell-cell AJ. {ECO:0000250|UniProtKB:Q9Z2J4}.
Q10469	reviewed	MGAT2_HUMAN	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (GNT-II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II)	MGAT2	Homo sapiens (Human)	447	FUNCTION: Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans. {ECO:0000269|PubMed:11228641, ECO:0000269|PubMed:29666272, ECO:0000269|PubMed:8808595}.		oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; viral protein processing [GO:0019082]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0008455]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]; alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0008455]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]; oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:20378551}; Single-pass type II membrane protein {ECO:0000305}.
Q10471	reviewed	GALT2_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form]	GALNT2	Homo sapiens (Human)	571	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism (PubMed:27508872, PubMed:32293671). {ECO:0000269|PubMed:12438318, ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:25939779, ECO:0000269|PubMed:27508872, ECO:0000269|PubMed:32293671, ECO:0000269|PubMed:7592619, ECO:0000269|PubMed:9295285}.		O-glycan processing [GO:0016266]; protein maturation [GO:0051604]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]	endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; O-glycan processing [GO:0016266]; protein maturation [GO:0051604]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:9394011}; Single-pass type II membrane protein {ECO:0000269|PubMed:9394011}. Secreted {ECO:0000269|PubMed:9394011}. Note=Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.
Q10472	reviewed	GALT1_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 1 (EC 2.4.1.41) (Polypeptide GalNAc transferase 1) (GalNAc-T1) (pp-GaNTase 1) (Protein-UDP acetylgalactosaminyltransferase 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 1 soluble form]	GALNT1	Homo sapiens (Human)	559	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:8690719, PubMed:9295285). Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides (PubMed:9295285). {ECO:0000269|PubMed:8690719, ECO:0000269|PubMed:9295285}.		O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]; viral protein processing [GO:0019082]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: [Polypeptide N-acetylgalactosaminyltransferase 1]: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Polypeptide N-acetylgalactosaminyltransferase 1 soluble form]: Secreted.
Q10567	reviewed	AP1B1_HUMAN	AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)	AP1B1 ADTB1 BAM22 CLAPB2	Homo sapiens (Human)	949	FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed:31630791). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. {ECO:0000269|PubMed:31630791}.		basolateral protein secretion [GO:0110010]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; vesicle-mediated transport [GO:0016192]	AP-1 adaptor complex [GO:0030121]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]	clathrin binding [GO:0030276]; protein kinase binding [GO:0019901]	AP-1 adaptor complex [GO:0030121]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]; clathrin binding [GO:0030276]; protein kinase binding [GO:0019901]; basolateral protein secretion [GO:0110010]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Q10570	reviewed	CPSF1_HUMAN	Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)	CPSF1 CPSF160	Homo sapiens (Human)	1443	FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). {ECO:0000250|UniProtKB:A0A0R4IC37, ECO:0000269|PubMed:14749727}.		co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180012]; mRNA polyadenylation [GO:0006378]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	enzyme binding [GO:0019899]; mRNA 3'-UTR AU-rich region binding [GO:0035925]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180012]; mRNA polyadenylation [GO:0006378]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm.
Q10571	reviewed	MN1_HUMAN	Transcriptional activator MN1 (Probable tumor suppressor protein MN1)	MN1	Homo sapiens (Human)	1320	FUNCTION: Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}.		intramembranous ossification [GO:0001957]; negative regulation of osteoblast proliferation [GO:0033689]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]		nucleus [GO:0005634]; intramembranous ossification [GO:0001957]; negative regulation of osteoblast proliferation [GO:0033689]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31839203}.
Q10586	reviewed	DBP_HUMAN	D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (Tax-responsive enhancer element-binding protein 302) (TaxREB302)	DBP	Homo sapiens (Human)	325	FUNCTION: This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Nucleus.
Q10587	reviewed	TEF_HUMAN	Thyrotroph embryonic factor	TEF KIAA1655	Homo sapiens (Human)	303	FUNCTION: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.		regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Nucleus.
Q10588	reviewed	BST1_HUMAN	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC 3.2.2.6) (ADP-ribosyl cyclase 2) (Bone marrow stromal cell antigen 1) (BST-1) (Cyclic ADP-ribose hydrolase 2) (cADPR hydrolase 2) (CD antigen CD157)	BST1	Homo sapiens (Human)	318	FUNCTION: Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed:7805847). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable). {ECO:0000269|PubMed:7805847, ECO:0000305|PubMed:11866528, ECO:0000305|PubMed:7805847, ECO:0000305|PubMed:8202488}.		humoral immune response [GO:0006959]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cell-matrix adhesion [GO:0001952]; regulation of cellular extravasation [GO:0002691]; regulation of inflammatory response [GO:0050727]; regulation of integrin-mediated signaling pathway [GO:2001044]; regulation of neutrophil chemotaxis [GO:0090022]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of superoxide metabolic process [GO:0090322]; signal transduction [GO:0007165]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; uropod [GO:0001931]	ADP-ribosyl cyclase activity [GO:0061811]; cyclic ADP-ribose hydrolase [GO:0061812]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; phosphorus-oxygen lyase activity [GO:0016849]; transferase activity [GO:0016740]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; uropod [GO:0001931]; ADP-ribosyl cyclase activity [GO:0061811]; cyclic ADP-ribose hydrolase [GO:0061812]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; phosphorus-oxygen lyase activity [GO:0016849]; transferase activity [GO:0016740]; humoral immune response [GO:0006959]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cell-matrix adhesion [GO:0001952]; regulation of cellular extravasation [GO:0002691]; regulation of inflammatory response [GO:0050727]; regulation of integrin-mediated signaling pathway [GO:2001044]; regulation of neutrophil chemotaxis [GO:0090022]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of superoxide metabolic process [GO:0090322]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:8202488}.
Q10589	reviewed	BST2_HUMAN	Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317)	BST2	Homo sapiens (Human)	180	FUNCTION: IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted (PubMed:22520941, PubMed:21529378, PubMed:20940320, PubMed:20419159, PubMed:20399176, PubMed:19879838, PubMed:19036818, PubMed:18342597, PubMed:18200009). Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, paramyxoviridae: nipah virus, and coronaviridae: SARS-CoV (PubMed:22520941, PubMed:21621240, PubMed:21529378, PubMed:20943977, PubMed:20686043, PubMed:20419159, PubMed:20399176, PubMed:19879838, PubMed:19179289, PubMed:18342597, PubMed:18200009, PubMed:26378163, PubMed:31199522). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration (PubMed:22065321). Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439). Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2 (PubMed:23028328). {ECO:0000269|PubMed:18200009, ECO:0000269|PubMed:18342597, ECO:0000269|PubMed:19036818, ECO:0000269|PubMed:19179289, ECO:0000269|PubMed:19564354, ECO:0000269|PubMed:19879838, ECO:0000269|PubMed:20399176, ECO:0000269|PubMed:20419159, ECO:0000269|PubMed:20686043, ECO:0000269|PubMed:20940320, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21529378, ECO:0000269|PubMed:21621240, ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:22520941, ECO:0000269|PubMed:23028328, ECO:0000269|PubMed:26172439, ECO:0000269|PubMed:26378163, ECO:0000269|PubMed:31199522}.	MISCELLANEOUS: Tetherin shows evidence of positive (adaptive) selection, presumably as a result of evolutionary pressure applied by antagonistic viral proteins that counteract its inhibitiory activity and this has led to the species-specific tetherin sensitivity to viral countermeasures. For example, Tantalus monkey tetherin cannot be abrogated by HIV-1 VPU due to variation in the tetherin transmembrane region. Similarly, SIV Nefs are able to overcome simian tetherins, but not human tetherin, due to a unique 5-amino-acid deletion in the cytoplasmic tail domain of human tetherin (PubMed:19917491). {ECO:0000305|PubMed:19917491}.; MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at Met-13 of isoform 1. {ECO:0000305}.	B cell activation [GO:0042113]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of intracellular transport of viral material [GO:1901253]; negative regulation of plasmacytoid dendritic cell cytokine production [GO:0002737]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of leukocyte proliferation [GO:0070665]; regulation of actin cytoskeleton organization [GO:0032956]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; response to virus [GO:0009615]	apical plasma membrane [GO:0016324]; azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	identical protein binding [GO:0042802]; metalloendopeptidase inhibitor activity [GO:0008191]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]	apical plasma membrane [GO:0016324]; azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; identical protein binding [GO:0042802]; metalloendopeptidase inhibitor activity [GO:0008191]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; B cell activation [GO:0042113]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of intracellular transport of viral material [GO:1901253]; negative regulation of plasmacytoid dendritic cell cytokine production [GO:0002737]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of leukocyte proliferation [GO:0070665]; regulation of actin cytoskeleton organization [GO:0032956]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network. Cell membrane {ECO:0000269|PubMed:26172439}; Single-pass type II membrane protein. Cell membrane {ECO:0000269|PubMed:19879838, ECO:0000269|PubMed:26172439}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19879838, ECO:0000305|PubMed:26172439}. Membrane raft. Cytoplasm. Apical cell membrane {ECO:0000250}. Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. Forms a complex with MMP14 and localizes to the cytoplasm.; SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:26172439}. Late endosome {ECO:0000269|PubMed:20419159}. Note=(Microbial infection) HIV-1 VPU and HIV-2 ENV can target it to the trans-Golgi network thus sequestering it away from virus assembly sites on the cell membrane. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. {ECO:0000269|PubMed:20419159, ECO:0000269|PubMed:26172439}.
Q10713	reviewed	MPPA_HUMAN	Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) (Inactive zinc metalloprotease alpha) (P-55)	PMPCA INPP5E KIAA0123 MPPA	Homo sapiens (Human)	525	FUNCTION: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. {ECO:0000269|PubMed:25808372}.		protein processing involved in protein targeting to mitochondrion [GO:0006627]	extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; mitochondrial processing peptidase complex [GO:0017087]; mitochondrion [GO:0005739]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; mitochondrial processing peptidase complex [GO:0017087]; mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; protein processing involved in protein targeting to mitochondrion [GO:0006627]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P20069}. Mitochondrion inner membrane {ECO:0000269|PubMed:25808372}.
Q10981	reviewed	FUT2_HUMAN	Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)	FUT2 SEC2	Homo sapiens (Human)	343	FUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:7876235, PubMed:8018146, PubMed:12692541). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:22068912, PubMed:21625510, PubMed:24733310). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235). {ECO:0000250|UniProtKB:Q9JL27, ECO:0000269|PubMed:12692541, ECO:0000269|PubMed:21625510, ECO:0000269|PubMed:22068912, ECO:0000269|PubMed:24733310, ECO:0000269|PubMed:7876235, ECO:0000269|PubMed:8018146}.	MISCELLANEOUS: There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.	carbohydrate metabolic process [GO:0005975]; fucosylation [GO:0036065]; glycolipid metabolic process [GO:0006664]; L-fucose catabolic process [GO:0042355]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; regulation of cell adhesion [GO:0030155]; regulation of endothelial cell proliferation [GO:0001936]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	alpha-(1,2)-fucosyltransferase activity [GO:0031127]; fucosyltransferase activity [GO:0008417]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; alpha-(1,2)-fucosyltransferase activity [GO:0031127]; fucosyltransferase activity [GO:0008417]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]; carbohydrate metabolic process [GO:0005975]; fucosylation [GO:0036065]; glycolipid metabolic process [GO:0006664]; L-fucose catabolic process [GO:0042355]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; regulation of cell adhesion [GO:0030155]; regulation of endothelial cell proliferation [GO:0001936]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Q11128	reviewed	FUT5_HUMAN	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (EC 2.4.1.152) (3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT5) (EC 2.4.1.65) (Fucosyltransferase 5) (Fucosyltransferase V) (Fuc-TV) (FucT-V) (Galactoside 3-L-fucosyltransferase)	FUT5	Homo sapiens (Human)	374	FUNCTION: Catalyzes preferentially the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl-beta-D-glucosamine (GlcNAc) of an N-acetyllactosamine unit (type 2 chain) of an oligosaccharide, or a glycoprotein- and a glycolipid-linked N-acetyllactosamine unit via an alpha (1,3) linkage and participates in the surface expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens (PubMed:14718375, PubMed:1740457, PubMed:7721776, PubMed:9737988, PubMed:17604274, PubMed:9737989, PubMed:29593094). Preferentially transfers fucose to the GlcNAc of an internal N-acetyllactosamine unit of a poly-N-acetyllactosamine chain acceptor substrate (PubMed:7721776, PubMed:17604274). Also catalyzes to a lesser extend the transfer of L-fucose to the GlcNAc of a type 1 (beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl) or H-type 1 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc) chain oligosaccharide via an alpha (1,4) linkage (PubMed:14718375, PubMed:1740457, PubMed:7721776, PubMed:9737988, PubMed:17604274). Preferentially catalyzes sialylated type 2 oligosaccharide acceptors over neutral type 2 or H type 2 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc) oligosaccharide acceptors (PubMed:1740457, PubMed:9737989). Lactose-based structures are also acceptor substrates (PubMed:1740457, PubMed:7721776). {ECO:0000269|PubMed:14718375, ECO:0000269|PubMed:1740457, ECO:0000269|PubMed:17604274, ECO:0000269|PubMed:7721776, ECO:0000269|PubMed:9737988, ECO:0000269|PubMed:9737989}.		carbohydrate metabolic process [GO:0005975]; ceramide metabolic process [GO:0006672]; fucosylation [GO:0036065]; L-fucose catabolic process [GO:0042355]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity [GO:0017060]; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity [GO:0017060]; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]; carbohydrate metabolic process [GO:0005975]; ceramide metabolic process [GO:0006672]; fucosylation [GO:0036065]; L-fucose catabolic process [GO:0042355]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Q11130	reviewed	FUT7_HUMAN	Alpha-(1,3)-fucosyltransferase 7 (EC 2.4.1.-) (Fucosyltransferase 7) (Fucosyltransferase VII) (Fuc-TVII) (FucT-VII) (Galactoside 3-L-fucosyltransferase) (Selectin ligand synthase)	FUT7	Homo sapiens (Human)	342	FUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein or a glycolipid-linked sialopolylactosamines chain through an alpha-1,3 glycosidic linkage and participates in the final fucosylation step in the biosynthesis of the sialyl Lewis X (sLe(x)), a carbohydrate involved in cell and matrix adhesion during leukocyte trafficking and fertilization (PubMed:8207002, PubMed:8752218, PubMed:8666674, PubMed:9299472, PubMed:9405391, PubMed:9473504, PubMed:9499379, PubMed:9461592, PubMed:15632313, PubMed:15926890, PubMed:18553500, PubMed:18402946, PubMed:11404359, PubMed:29593094). In vitro, also synthesizes sialyl-dimeric-Lex structures, from VIM-2 structures and both di-fucosylated and trifucosylated structures from mono-fucosylated precursors (PubMed:9499379). However does not catalyze alpha 1-3 fucosylation when an internal alpha 1-3 fucosylation is present in polylactosamine chain and the fucosylation rate of the internal GlcNAc residues is reduced once fucose has been added to the distal GlcNAc (PubMed:9473504, PubMed:9499379). Also catalyzes the transfer of a fucose from GDP-beta-fucose to the 6-sulfated a(2,3)sialylated substrate to produce 6-sulfo sLex mediating significant L-selectin-dependent cell adhesion (PubMed:10200296, PubMed:8752218). Through sialyl-Lewis(x) biosynthesis, can control SELE- and SELP-mediated cell adhesion with leukocytes and allows leukocytes tethering and rolling along the endothelial tissue thereby enabling the leukocytes to accumulate at a site of inflammation (PubMed:10386892, PubMed:29138114, PubMed:8666674, PubMed:9473504, PubMed:9834120). May enhance embryo implantation through sialyl Lewis X (sLeX)-mediated adhesion of embryo cells to endometrium (PubMed:18402946, PubMed:18553500). May affect insulin signaling by up-regulating the phosphorylation and expression of some signaling molecules involved in the insulin-signaling pathway through SLe(x) which is present on the glycans of the INSRR alpha subunit (PubMed:17229154). {ECO:0000269|PubMed:10200296, ECO:0000269|PubMed:10386892, ECO:0000269|PubMed:11404359, ECO:0000269|PubMed:15632313, ECO:0000269|PubMed:15926890, ECO:0000269|PubMed:17229154, ECO:0000269|PubMed:18402946, ECO:0000269|PubMed:18553500, ECO:0000269|PubMed:29138114, ECO:0000269|PubMed:8207002, ECO:0000269|PubMed:8666674, ECO:0000269|PubMed:8752218, ECO:0000269|PubMed:9299472, ECO:0000269|PubMed:9405391, ECO:0000269|PubMed:9461592, ECO:0000269|PubMed:9473504, ECO:0000269|PubMed:9499379, ECO:0000269|PubMed:9834120}.		CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; ceramide metabolic process [GO:0006672]; embryo implantation [GO:0007566]; fucosylation [GO:0036065]; inflammatory response [GO:0006954]; L-fucose catabolic process [GO:0042355]; leukocyte migration involved in immune response [GO:0002522]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte migration into lymph node [GO:0097022]; oligosaccharide biosynthetic process [GO:0009312]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of neutrophil migration [GO:1902624]; protein glycosylation [GO:0006486]; regulation of cell adhesion molecule production [GO:0060353]; regulation of cell-cell adhesion [GO:0022407]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of leukocyte cell-cell adhesion [GO:1903037]; regulation of leukocyte tethering or rolling [GO:1903236]; regulation of neutrophil extravasation [GO:2000389]; regulation of type IV hypersensitivity [GO:0001807]; T cell migration [GO:0072678]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; ceramide metabolic process [GO:0006672]; embryo implantation [GO:0007566]; fucosylation [GO:0036065]; inflammatory response [GO:0006954]; L-fucose catabolic process [GO:0042355]; leukocyte migration involved in immune response [GO:0002522]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte migration into lymph node [GO:0097022]; oligosaccharide biosynthetic process [GO:0009312]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of neutrophil migration [GO:1902624]; protein glycosylation [GO:0006486]; regulation of cell adhesion molecule production [GO:0060353]; regulation of cell-cell adhesion [GO:0022407]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of leukocyte cell-cell adhesion [GO:1903037]; regulation of leukocyte tethering or rolling [GO:1903236]; regulation of neutrophil extravasation [GO:2000389]; regulation of type IV hypersensitivity [GO:0001807]; T cell migration [GO:0072678]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Q11201	reviewed	SIA4A_HUMAN	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) (EC 2.4.3.2) (SIATFL) (ST3Gal I) (ST3GalI) (ST3GalA.1) (ST3O) (Sialyltransferase 4A) (SIAT4-A)	ST3GAL1 SIAT4 SIAT4A	Homo sapiens (Human)	340	FUNCTION: A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:31784620, PubMed:8027041). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:31784620, PubMed:8027041). Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans. As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (By similarity). Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser (By similarity). Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8027041) (By similarity). {ECO:0000250|UniProtKB:P54751, ECO:0000269|PubMed:31784620, ECO:0000269|PubMed:8027041}.		ganglioside biosynthetic process via lactosylceramide [GO:0010706]; keratan sulfate biosynthetic process [GO:0018146]; memory B cell differentiation [GO:0002319]; N-acetylneuraminate metabolic process [GO:0006054]; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process [GO:1905403]; O-glycan processing [GO:0016266]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487]; protein sialylation [GO:1990743]; sialylation [GO:0097503]; viral protein processing [GO:0019082]	extracellular exosome [GO:0070062]; Golgi medial cisterna membrane [GO:1990675]; Golgi membrane [GO:0000139]; Golgi trans cisterna membrane [GO:1990676]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588]	beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase [GO:0047288]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; sialyltransferase activity [GO:0008373]	extracellular exosome [GO:0070062]; Golgi medial cisterna membrane [GO:1990675]; Golgi membrane [GO:0000139]; Golgi trans cisterna membrane [GO:1990676]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588]; beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase [GO:0047288]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; sialyltransferase activity [GO:0008373]; ganglioside biosynthetic process via lactosylceramide [GO:0010706]; keratan sulfate biosynthetic process [GO:0018146]; memory B cell differentiation [GO:0002319]; N-acetylneuraminate metabolic process [GO:0006054]; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process [GO:1905403]; O-glycan processing [GO:0016266]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487]; protein sialylation [GO:1990743]; sialylation [GO:0097503]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:9182658}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:9182658}; Single-pass type II membrane protein {ECO:0000255}. Secreted. Note=Membrane-bound form in medial and trans cisternae of Golgi (PubMed:9182658). Secreted into the body fluid. {ECO:0000269|PubMed:9182658}.
Q11203	reviewed	SIAT6_HUMAN	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (EC 2.4.3.6) (Beta-galactoside alpha-2,3-sialyltransferase 3) (Alpha 2,3-ST 3) (Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase) (N-acetyllactosaminide alpha-2,3-sialyltransferase) (ST3Gal III) (ST3GalIII) (ST3N) (Sialyltransferase 6)	ST3GAL3 SIAT6	Homo sapiens (Human)	375	FUNCTION: Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc. {ECO:0000250|UniProtKB:P97325}.	MISCELLANEOUS: [Isoform B1+32]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform B4+173]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform B5+173]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform B10]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform C9]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform E1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform E3+32]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	ganglioside biosynthetic process via lactosylceramide [GO:0010706]; keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; viral protein processing [GO:0019082]	extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; N-acetyllactosaminide alpha-2,3-sialyltransferase activity [GO:0008118]; sialyltransferase activity [GO:0008373]	extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; N-acetyllactosaminide alpha-2,3-sialyltransferase activity [GO:0008118]; sialyltransferase activity [GO:0008373]; ganglioside biosynthetic process via lactosylceramide [GO:0010706]; keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Q11206	reviewed	SIA4C_HUMAN	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (Alpha 2,3-ST 4) (Beta-galactoside alpha-2,3-sialyltransferase 4) (EC 2.4.3.2) (EC 2.4.3.4) (Alpha 2,3-sialyltransferase IV) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase) (N-acetyllactosaminide alpha-2,3-sialyltransferase) (EC 2.4.3.6) (SAT-3) (ST-4) (ST3Gal IV) (ST3GalIV) (ST3GalA.2) (STZ) (Sialyltransferase 4C) (SIAT4-C)	ST3GAL4 CGS23 NANTA3 SIAT4C STZ	Homo sapiens (Human)	333	FUNCTION: A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8288606, PubMed:8611500). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8288606, PubMed:8611500). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (PubMed:8288606). Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (PubMed:8611500). {ECO:0000250|UniProtKB:P61131, ECO:0000250|UniProtKB:Q91Y74, ECO:0000269|PubMed:25498912, ECO:0000269|PubMed:8288606, ECO:0000269|PubMed:8611500}.		cognition [GO:0050890]; glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101]; keratan sulfate biosynthetic process [GO:0018146]; lipid glycosylation [GO:0030259]; O-glycan processing [GO:0016266]; oligosaccharide biosynthetic process [GO:0009312]; positive regulation of blood coagulation [GO:0030194]; positive regulation of leukocyte tethering or rolling [GO:1903238]; protein glycosylation [GO:0006486]; protein sialylation [GO:1990743]; sialylation [GO:0097503]; viral protein processing [GO:0019082]	extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase [GO:0047288]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; N-acetyllactosaminide alpha-2,3-sialyltransferase activity [GO:0008118]; sialyltransferase activity [GO:0008373]	extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase [GO:0047288]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; N-acetyllactosaminide alpha-2,3-sialyltransferase activity [GO:0008118]; sialyltransferase activity [GO:0008373]; cognition [GO:0050890]; glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101]; keratan sulfate biosynthetic process [GO:0018146]; lipid glycosylation [GO:0030259]; O-glycan processing [GO:0016266]; oligosaccharide biosynthetic process [GO:0009312]; positive regulation of blood coagulation [GO:0030194]; positive regulation of leukocyte tethering or rolling [GO:1903238]; protein glycosylation [GO:0006486]; protein sialylation [GO:1990743]; sialylation [GO:0097503]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Q12756	reviewed	KIF1A_HUMAN	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104)	KIF1A ATSV C2orf20	Homo sapiens (Human)	1690	FUNCTION: Motor for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. {ECO:0000250|UniProtKB:F1M4A4, ECO:0000269|PubMed:33880452}.		anterograde axonal transport [GO:0008089]; anterograde neuronal dense core vesicle transport [GO:1990048]; cytoskeleton-dependent intracellular transport [GO:0030705]; dense core granule cytoskeletal transport [GO:0099519]; microtubule-based movement [GO:0007018]; regulation of dendritic spine development [GO:0060998]; regulation of dendritic spine morphogenesis [GO:0061001]; retrograde neuronal dense core vesicle transport [GO:1990049]; vesicle-mediated transport [GO:0016192]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; neuronal dense core vesicle [GO:0098992]; neuronal dense core vesicle membrane [GO:0099012]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; neuronal dense core vesicle [GO:0098992]; neuronal dense core vesicle membrane [GO:0099012]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]; anterograde axonal transport [GO:0008089]; anterograde neuronal dense core vesicle transport [GO:1990048]; cytoskeleton-dependent intracellular transport [GO:0030705]; dense core granule cytoskeletal transport [GO:0099519]; microtubule-based movement [GO:0007018]; regulation of dendritic spine development [GO:0060998]; regulation of dendritic spine morphogenesis [GO:0061001]; retrograde neuronal dense core vesicle transport [GO:1990049]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21376300}. Cell projection, neuron projection {ECO:0000269|PubMed:25265257, ECO:0000269|PubMed:32652677, ECO:0000269|PubMed:33880452}. Cell projection, axon {ECO:0000250|UniProtKB:P33173}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P33173}. Synapse {ECO:0000250|UniProtKB:P33173}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250|UniProtKB:F1M4A4}; Peripheral membrane protein {ECO:0000250|UniProtKB:F1M4A4}; Cytoplasmic side {ECO:0000250|UniProtKB:F1M4A4}. Note=Within neuronal cells concentrated in the axon, with smaller amounts in the perinuclear and synaptic regions (By similarity). Accumulates at the distal tip of growing neurites. {ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:25265257, ECO:0000269|PubMed:33880452}.
Q12765	reviewed	SCRN1_HUMAN	Secernin-1	SCRN1 KIAA0193	Homo sapiens (Human)	414	FUNCTION: Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). {ECO:0000250}.	MISCELLANEOUS: 'Secern' is an archaic English term meaning 'secrete'.	exocytosis [GO:0006887]; proteolysis [GO:0006508]; regulation of synaptic vesicle cycle [GO:0098693]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; presynapse [GO:0098793]	cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; presynapse [GO:0098793]; cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805]; exocytosis [GO:0006887]; proteolysis [GO:0006508]; regulation of synaptic vesicle cycle [GO:0098693]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q12768	reviewed	WASC5_HUMAN	WASH complex subunit 5 (Strumpellin) (WASH complex subunit strumpellin)	WASHC5 KIAA0196	Homo sapiens (Human)	1159	FUNCTION: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666). {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20833645, ECO:0000269|PubMed:23085491, ECO:0000269|PubMed:23676666}.		actin filament polymerization [GO:0030041]; endosomal transport [GO:0016197]; endosome fission [GO:0140285]; endosome organization [GO:0007032]; lysosome organization [GO:0007040]; meiotic spindle assembly [GO:0090306]; oocyte maturation [GO:0001556]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of neuron projection development [GO:0010976]; protein transport [GO:0015031]; protein-containing complex localization [GO:0031503]; regulation of actin nucleation [GO:0051125]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of vesicle size [GO:0097494]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203]		cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203]; actin filament polymerization [GO:0030041]; endosomal transport [GO:0016197]; endosome fission [GO:0140285]; endosome organization [GO:0007032]; lysosome organization [GO:0007040]; meiotic spindle assembly [GO:0090306]; oocyte maturation [GO:0001556]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of neuron projection development [GO:0010976]; protein transport [GO:0015031]; protein-containing complex localization [GO:0031503]; regulation of actin nucleation [GO:0051125]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of vesicle size [GO:0097494]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20833645}. Endoplasmic reticulum {ECO:0000269|PubMed:20833645}. Early endosome {ECO:0000269|PubMed:23085491, ECO:0000269|PubMed:23676666}. Note=Colocalizes with SYP/synaptophysin in the external molecular layer of the dentate gyrus and in motoneurons of the ventral horn of spinal cord. {ECO:0000269|PubMed:20833645}.
Q12769	reviewed	NU160_HUMAN	Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160)	NUP160 KIAA0197 NUP120	Homo sapiens (Human)	1436	FUNCTION: Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Involved in poly(A)+ RNA transport. {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:11684705}.		mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; structural constituent of nuclear pore [GO:0017056]; mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:11684705}.
Q12770	reviewed	SCAP_HUMAN	Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)	SCAP KIAA0199 PSEC0227	Homo sapiens (Human)	1279	FUNCTION: Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260}.		cellular lipid metabolic process [GO:0044255]; cholesterol metabolic process [GO:0008203]; COPII-coated vesicle cargo loading [GO:0090110]; immune response [GO:0006955]; negative regulation of cholesterol biosynthetic process [GO:0045541]; positive regulation of cholesterol biosynthetic process [GO:0045542]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of fatty acid biosynthetic process [GO:0042304]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; SREBP signaling pathway [GO:0032933]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SREBP-SCAP complex [GO:0032936]	protein-containing complex binding [GO:0044877]; sterol binding [GO:0032934]; unfolded protein binding [GO:0051082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SREBP-SCAP complex [GO:0032936]; protein-containing complex binding [GO:0044877]; sterol binding [GO:0032934]; unfolded protein binding [GO:0051082]; cellular lipid metabolic process [GO:0044255]; cholesterol metabolic process [GO:0008203]; COPII-coated vesicle cargo loading [GO:0090110]; immune response [GO:0006955]; negative regulation of cholesterol biosynthetic process [GO:0045541]; positive regulation of cholesterol biosynthetic process [GO:0045542]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of fatty acid biosynthetic process [GO:0042304]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; SREBP signaling pathway [GO:0032933]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:32111832}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:32111832}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:P97260}; Multi-pass membrane protein {ECO:0000255}. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols (By similarity). Requires the presence of SPRING1 for proper localization to endoplasmic reticulum (PubMed:32111832). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:32111832}.
Q12772	reviewed	SRBP2_HUMAN	Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]	SREBF2 BHLHD2 SREBP2	Homo sapiens (Human)	1141	FUNCTION: [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:7903453, PubMed:12177166). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}.		cellular response to laminar fluid shear stress [GO:0071499]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to starvation [GO:0009267]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of Notch signaling pathway [GO:0008593]; SREBP signaling pathway [GO:0032933]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SREBP-SCAP-Insig complex [GO:0032937]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SREBP-SCAP-Insig complex [GO:0032937]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to starvation [GO:0009267]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of Notch signaling pathway [GO:0008593]; SREBP signaling pathway [GO:0032933]	SUBCELLULAR LOCATION: [Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12202038}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000303|PubMed:28849786}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000303|PubMed:28849786}; Multi-pass membrane protein {ECO:0000255}. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum (PubMed:32322062). Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; SUBCELLULAR LOCATION: [Processed sterol regulatory element-binding protein 2]: Nucleus {ECO:0000269|PubMed:11477106, ECO:0000269|PubMed:32322062}. Note=Transported into the nucleus with the help of importin-beta. Dimerization of the bHLH domain is a prerequisite for importin beta-dependent nuclear import. {ECO:0000250|UniProtKB:Q3U1N2}.
Q12774	reviewed	ARHG5_HUMAN	Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)	ARHGEF5 TIM	Homo sapiens (Human)	1597	FUNCTION: Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}.		actin cytoskeleton organization [GO:0030036]; hematopoietic stem cell homeostasis [GO:0061484]; intracellular signal transduction [GO:0035556]; myeloid dendritic cell chemotaxis [GO:0002408]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein import [GO:1904591]; positive regulation of stress fiber assembly [GO:0051496]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cytoskeleton organization [GO:0051493]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]	anchoring junction [GO:0070161]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102]	GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289]	anchoring junction [GO:0070161]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289]; actin cytoskeleton organization [GO:0030036]; hematopoietic stem cell homeostasis [GO:0061484]; intracellular signal transduction [GO:0035556]; myeloid dendritic cell chemotaxis [GO:0002408]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein import [GO:1904591]; positive regulation of stress fiber assembly [GO:0051496]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cytoskeleton organization [GO:0051493]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:25911094}. Nucleus {ECO:0000269|PubMed:14662653}. Cell projection, podosome {ECO:0000250|UniProtKB:E9Q7D5}.
Q12778	reviewed	FOXO1_HUMAN	Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)	FOXO1 FKHR FOXO1A	Homo sapiens (Human)	655	FUNCTION: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}.		apoptotic process [GO:0006915]; autophagy [GO:0006914]; blood vessel development [GO:0001568]; canonical Wnt signaling pathway [GO:0060070]; cellular response to cold [GO:0070417]; cellular response to hyperoxia [GO:0071455]; cellular response to insulin stimulus [GO:0032869]; cellular response to nitric oxide [GO:0071732]; cellular response to oxidative stress [GO:0034599]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; energy homeostasis [GO:0097009]; fat cell differentiation [GO:0045444]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; intracellular glucose homeostasis [GO:0001678]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of insulin secretion [GO:0046676]; negative regulation of stress-activated MAPK cascade [GO:0032873]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein acetylation [GO:0006473]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of transcription by RNA polymerase II [GO:0006357]; response to fatty acid [GO:0070542]; temperature homeostasis [GO:0001659]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nucleic acid binding [GO:0003676]; promoter-specific chromatin binding [GO:1990841]; protein phosphatase 2A binding [GO:0051721]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nucleic acid binding [GO:0003676]; promoter-specific chromatin binding [GO:1990841]; protein phosphatase 2A binding [GO:0051721]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; autophagy [GO:0006914]; blood vessel development [GO:0001568]; canonical Wnt signaling pathway [GO:0060070]; cellular response to cold [GO:0070417]; cellular response to hyperoxia [GO:0071455]; cellular response to insulin stimulus [GO:0032869]; cellular response to nitric oxide [GO:0071732]; cellular response to oxidative stress [GO:0034599]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; energy homeostasis [GO:0097009]; fat cell differentiation [GO:0045444]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; intracellular glucose homeostasis [GO:0001678]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of insulin secretion [GO:0046676]; negative regulation of stress-activated MAPK cascade [GO:0032873]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein acetylation [GO:0006473]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of transcription by RNA polymerase II [GO:0006357]; response to fatty acid [GO:0070542]; temperature homeostasis [GO:0001659]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11237865, ECO:0000269|PubMed:11311120, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:25009184, ECO:0000269|PubMed:31063815}. Nucleus {ECO:0000269|PubMed:11311120, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:25009184, ECO:0000269|PubMed:31063815}. Note=Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells (PubMed:11311120, PubMed:12228231, PubMed:19221179, PubMed:21245099, PubMed:20543840, PubMed:25009184). In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteasomal pathway (PubMed:11237865, PubMed:12228231). Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation (PubMed:18356527). Phosphorylation by NLK results in nuclear export (By similarity). Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1 (PubMed:19221179, PubMed:21245099). SGK1-mediated phosphorylation also results in nuclear translocation (By similarity). Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide (By similarity). Retained in the nucleus on methylation (By similarity). PPIA/CYPA stimulates its nuclear accumulation (PubMed:31063815). Deacetylation by SIRT6, promotes its translocation into the cytoplasm (PubMed:25009184). {ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:11237865, ECO:0000269|PubMed:11311120, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:25009184, ECO:0000269|PubMed:31063815}.
Q12788	reviewed	TBL3_HUMAN	Transducin beta-like protein 3 (WD repeat-containing protein SAZD)	TBL3 SAZD	Homo sapiens (Human)	808	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}.		endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; ribosomal small subunit biogenesis [GO:0042274]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511]; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:34516797}.
Q12789	reviewed	TF3C1_HUMAN	General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha)	GTF3C1	Homo sapiens (Human)	2109	FUNCTION: Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.		5S class rRNA transcription by RNA polymerase III [GO:0042791]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription [GO:0009304]; tRNA transcription by RNA polymerase III [GO:0042797]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; transcription factor TFIIIC complex [GO:0000127]	DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; transcription factor TFIIIC complex [GO:0000127]; DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; 5S class rRNA transcription by RNA polymerase III [GO:0042791]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription [GO:0009304]; tRNA transcription by RNA polymerase III [GO:0042797]	SUBCELLULAR LOCATION: Nucleus.
Q12791	reviewed	KCMA1_HUMAN	Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)	KCNMA1 KCNMA SLO	Homo sapiens (Human)	1236	FUNCTION: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:29330545, PubMed:31152168). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). {ECO:0000269|PubMed:29330545, ECO:0000269|PubMed:31152168}.	MISCELLANEOUS: The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel also contains binding sites for Ca(2+) and Mg(2+).	intracellular potassium ion homeostasis [GO:0030007]; micturition [GO:0060073]; negative regulation of cell volume [GO:0045794]; positive regulation of apoptotic process [GO:0043065]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to calcium ion [GO:0051592]; response to carbon monoxide [GO:0034465]; response to hypoxia [GO:0001666]; response to osmotic stress [GO:0006970]; smooth muscle contraction involved in micturition [GO:0060083]; vasodilation [GO:0042311]	apical plasma membrane [GO:0016324]; caveola [GO:0005901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076]	actin binding [GO:0003779]; calcium-activated potassium channel activity [GO:0015269]; identical protein binding [GO:0042802]; large conductance calcium-activated potassium channel activity [GO:0060072]; metal ion binding [GO:0046872]; voltage-gated potassium channel activity [GO:0005249]	apical plasma membrane [GO:0016324]; caveola [GO:0005901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076]; actin binding [GO:0003779]; calcium-activated potassium channel activity [GO:0015269]; identical protein binding [GO:0042802]; large conductance calcium-activated potassium channel activity [GO:0060072]; metal ion binding [GO:0046872]; voltage-gated potassium channel activity [GO:0005249]; intracellular potassium ion homeostasis [GO:0030007]; micturition [GO:0060073]; negative regulation of cell volume [GO:0045794]; positive regulation of apoptotic process [GO:0043065]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to calcium ion [GO:0051592]; response to carbon monoxide [GO:0034465]; response to hypoxia [GO:0001666]; response to osmotic stress [GO:0006970]; smooth muscle contraction involved in micturition [GO:0060083]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20693285, ECO:0000269|PubMed:22399288}; Multi-pass membrane protein {ECO:0000269|PubMed:20693285, ECO:0000269|PubMed:22399288}.
Q12792	reviewed	TWF1_HUMAN	Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)	TWF1 PTK9	Homo sapiens (Human)	350	FUNCTION: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). {ECO:0000250}.		actin filament depolymerization [GO:0030042]; barbed-end actin filament capping [GO:0051016]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of neuron projection development [GO:0010976]; regulation of actin phosphorylation [GO:0043538]; regulation of lamellipodium assembly [GO:0010591]; sequestering of actin monomers [GO:0042989]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; myofibril [GO:0030016]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; myofibril [GO:0030016]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; actin filament depolymerization [GO:0030042]; barbed-end actin filament capping [GO:0051016]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of neuron projection development [GO:0010976]; regulation of actin phosphorylation [GO:0043538]; regulation of lamellipodium assembly [GO:0010591]; sequestering of actin monomers [GO:0042989]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). {ECO:0000250}.
Q12794	reviewed	HYAL1_HUMAN	Hyaluronidase-1 (Hyal-1) (EC 3.2.1.35) (Hyaluronoglucosaminidase-1) (Lung carcinoma protein 1) (LuCa-1)	HYAL1 LUCA1	Homo sapiens (Human)	435	FUNCTION: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. {ECO:0000269|PubMed:12084718}.	MISCELLANEOUS: [Isoform 2]: Enzymatically inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Enzymatically inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Enzymatically inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Enzymatically inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Enzymatically inactive. {ECO:0000305}.	carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to pH [GO:0071467]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; chondroitin sulfate catabolic process [GO:0030207]; embryonic skeletal joint morphogenesis [GO:0060272]; glycosaminoglycan catabolic process [GO:0006027]; hyaluronan biosynthetic process [GO:0030213]; hyaluronan catabolic process [GO:0030214]; hyaluronan metabolic process [GO:0030212]; inflammatory response [GO:0006954]; negative regulation of cell growth [GO:0030308]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of growth [GO:0045927]; positive regulation of hyaluranon cable assembly [GO:1900106]; response to antibiotic [GO:0046677]; response to reactive oxygen species [GO:0000302]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; hyaluranon cable [GO:0036117]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	chondroitin hydrolase activity [GO:0052757]; hyaluronan synthase activity [GO:0050501]; hyalurononglucosaminidase activity [GO:0004415]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; hyaluranon cable [GO:0036117]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; chondroitin hydrolase activity [GO:0052757]; hyaluronan synthase activity [GO:0050501]; hyalurononglucosaminidase activity [GO:0004415]; carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to pH [GO:0071467]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; chondroitin sulfate catabolic process [GO:0030207]; embryonic skeletal joint morphogenesis [GO:0060272]; glycosaminoglycan catabolic process [GO:0006027]; hyaluronan biosynthetic process [GO:0030213]; hyaluronan catabolic process [GO:0030214]; hyaluronan metabolic process [GO:0030212]; inflammatory response [GO:0006954]; negative regulation of cell growth [GO:0030308]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of growth [GO:0045927]; positive regulation of hyaluranon cable assembly [GO:1900106]; response to antibiotic [GO:0046677]; response to reactive oxygen species [GO:0000302]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9223416}. Lysosome {ECO:0000269|PubMed:9223416}.
Q12797	reviewed	ASPH_HUMAN	Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase)	ASPH BAH	Homo sapiens (Human)	758	FUNCTION: [Isoform 1]: Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. {ECO:0000269|PubMed:11773073}.; FUNCTION: [Isoform 8]: Membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. {ECO:0000269|PubMed:22586105}.		activation of cysteine-type endopeptidase activity [GO:0097202]; activation of store-operated calcium channel activity [GO:0032237]; calcium ion homeostasis [GO:0055074]; calcium ion transmembrane transport [GO:0070588]; cell population proliferation [GO:0008283]; cellular response to calcium ion [GO:0071277]; detection of calcium ion [GO:0005513]; face morphogenesis [GO:0060325]; limb morphogenesis [GO:0035108]; muscle contraction [GO:0006936]; negative regulation of cell population proliferation [GO:0008285]; pattern specification process [GO:0007389]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteolysis [GO:0045862]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031585]; regulation of protein depolymerization [GO:1901879]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; response to ATP [GO:0033198]; roof of mouth development [GO:0060021]	calcium channel complex [GO:0034704]; cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; junctional sarcoplasmic reticulum membrane [GO:0014701]; plasma membrane [GO:0005886]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]	calcium ion binding [GO:0005509]; electron transfer activity [GO:0009055]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]; structural constituent of muscle [GO:0008307]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325]	calcium channel complex [GO:0034704]; cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; junctional sarcoplasmic reticulum membrane [GO:0014701]; plasma membrane [GO:0005886]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; calcium ion binding [GO:0005509]; electron transfer activity [GO:0009055]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]; structural constituent of muscle [GO:0008307]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325]; activation of cysteine-type endopeptidase activity [GO:0097202]; activation of store-operated calcium channel activity [GO:0032237]; calcium ion homeostasis [GO:0055074]; calcium ion transmembrane transport [GO:0070588]; cell population proliferation [GO:0008283]; cellular response to calcium ion [GO:0071277]; detection of calcium ion [GO:0005513]; face morphogenesis [GO:0060325]; limb morphogenesis [GO:0035108]; muscle contraction [GO:0006936]; negative regulation of cell population proliferation [GO:0008285]; pattern specification process [GO:0007389]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteolysis [GO:0045862]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031585]; regulation of protein depolymerization [GO:1901879]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; response to ATP [GO:0033198]; roof of mouth development [GO:0060021]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q28056}.; SUBCELLULAR LOCATION: [Isoform 4]: Sarcoplasmic reticulum membrane; Single-pass type II membrane protein {ECO:0000305|PubMed:15485681}.; SUBCELLULAR LOCATION: [Isoform 8]: Endoplasmic reticulum membrane; Single-pass type II membrane protein {ECO:0000269|PubMed:22586105}.
Q12798	reviewed	CETN1_HUMAN	Centrin-1 (Caltractin isoform 2)	CETN1 CEN1 CETN	Homo sapiens (Human)	172	FUNCTION: Plays a fundamental role in microtubule-organizing center structure and function (PubMed:8175926). Plays a role in sperm cilia formation (By similarity). {ECO:0000250|UniProtKB:P41209, ECO:0000269|PubMed:8175926}.	MISCELLANEOUS: Binds two moles of calcium per mole of protein.	cell division [GO:0051301]; cellular response to heat [GO:0034605]; centriole replication [GO:0007099]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair [GO:0006289]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; photoreceptor connecting cilium [GO:0032391]; spindle pole [GO:0000922]	calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; heterotrimeric G-protein binding [GO:0032795]; microtubule binding [GO:0008017]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; photoreceptor connecting cilium [GO:0032391]; spindle pole [GO:0000922]; calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; heterotrimeric G-protein binding [GO:0032795]; microtubule binding [GO:0008017]; cell division [GO:0051301]; cellular response to heat [GO:0034605]; centriole replication [GO:0007099]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair [GO:0006289]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:8175926}. Cell projection, cilium {ECO:0000250|UniProtKB:P41209}. Note=Centrosome of interphase and mitotic cells. In the retinal photoreceptor cells, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (By similarity). {ECO:0000250|UniProtKB:P41209, ECO:0000269|PubMed:8175926}.
Q12800	reviewed	TFCP2_HUMAN	Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF)	TFCP2 LSF SEF	Homo sapiens (Human)	502	FUNCTION: Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. {ECO:0000250, ECO:0000269|PubMed:10455131, ECO:0000269|PubMed:1732747, ECO:0000269|PubMed:8035790, ECO:0000269|PubMed:8157699}.	MISCELLANEOUS: In PubMed:8114710 authors noted that a 10-fold molar excess of isoform 3 over isoform 1 inhibited DNA-binding.	mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription factor binding [GO:0008134]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription factor binding [GO:0008134]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1732747, ECO:0000269|PubMed:7828600, ECO:0000269|PubMed:8114710}.
Q12802	reviewed	AKP13_HUMAN	A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)	AKAP13 BRX HT31 LBC	Homo sapiens (Human)	2813	FUNCTION: Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.		adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0086023]; adrenergic receptor signaling pathway [GO:0071875]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of Rho protein signal transduction [GO:0035023]; regulation of sarcomere organization [GO:0060297]; regulation of small GTPase mediated signal transduction [GO:0051056]	cell cortex [GO:0005938]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	guanyl-nucleotide exchange factor activity [GO:0005085]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; small GTPase binding [GO:0031267]	cell cortex [GO:0005938]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; guanyl-nucleotide exchange factor activity [GO:0005085]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; small GTPase binding [GO:0031267]; adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0086023]; adrenergic receptor signaling pathway [GO:0071875]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of Rho protein signal transduction [GO:0035023]; regulation of sarcomere organization [GO:0060297]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:9891067}. Cytoplasm {ECO:0000269|PubMed:9627117}. Cytoplasm, cell cortex {ECO:0000269|PubMed:11546812}. Nucleus {ECO:0000269|PubMed:9627117}. Membrane {ECO:0000269|PubMed:11696353, ECO:0000269|PubMed:9891067}; Peripheral membrane protein {ECO:0000269|PubMed:11696353, ECO:0000305|PubMed:9891067}. Note=Colocalizes with the actin cytoskeleton at the cell cortex. {ECO:0000269|PubMed:11546812}.
Q12805	reviewed	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3)	EFEMP1 FBLN3 FBNL	Homo sapiens (Human)	493	FUNCTION: Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. {ECO:0000269|PubMed:19804359, ECO:0000269|PubMed:19887559, ECO:0000269|PubMed:20005202}.	MISCELLANEOUS: Up-regulated in malignant gliomas. May increase glioma cell adhesiveness and invasive properties.	camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; epidermal growth factor receptor signaling pathway [GO:0007173]; negative regulation of chondrocyte differentiation [GO:0032331]; peptidyl-tyrosine phosphorylation [GO:0018108]; post-embryonic eye morphogenesis [GO:0048050]; regulation of DNA-templated transcription [GO:0006355]; visual perception [GO:0007601]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; epidermal growth factor receptor activity [GO:0005006]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; epidermal growth factor receptor activity [GO:0005006]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; epidermal growth factor receptor signaling pathway [GO:0007173]; negative regulation of chondrocyte differentiation [GO:0032331]; peptidyl-tyrosine phosphorylation [GO:0018108]; post-embryonic eye morphogenesis [GO:0048050]; regulation of DNA-templated transcription [GO:0006355]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Localizes to the lamina propria underneath the olfactory epithelium. {ECO:0000250}.
Q12809	reviewed	KCNH2_HUMAN	Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)	KCNH2 ERG ERG1 HERG	Homo sapiens (Human)	1159	FUNCTION: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661). {ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27916661}.; FUNCTION: [Isoform A-USO]: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. {ECO:0000269|PubMed:18559421}.; FUNCTION: [Isoform B-USO]: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. {ECO:0000269|PubMed:18559421}.	MISCELLANEOUS: [Isoform A-USO]: Twice more abundant than isoform 1 in heart. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3.1]: Primate-specific. Lacks a domain that is crucial for slow channel deactivation. {ECO:0000305}.	cardiac muscle contraction [GO:0060048]; cellular response to xenobiotic stimulus [GO:0071466]; membrane depolarization during action potential [GO:0086010]; membrane repolarization [GO:0086009]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of potassium ion export across plasma membrane [GO:1903765]; negative regulation of potassium ion transmembrane transport [GO:1901380]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export across plasma membrane [GO:0097623]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of heart rate by hormone [GO:0003064]; regulation of membrane potential [GO:0042391]; regulation of membrane repolarization [GO:0060306]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005]	cell surface [GO:0009986]; inward rectifier potassium channel complex [GO:1902937]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	C3HC4-type RING finger domain binding [GO:0055131]; delayed rectifier potassium channel activity [GO:0005251]; identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]	cell surface [GO:0009986]; inward rectifier potassium channel complex [GO:1902937]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; C3HC4-type RING finger domain binding [GO:0055131]; delayed rectifier potassium channel activity [GO:0005251]; identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]; cardiac muscle contraction [GO:0060048]; cellular response to xenobiotic stimulus [GO:0071466]; membrane depolarization during action potential [GO:0086010]; membrane repolarization [GO:0086009]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of potassium ion export across plasma membrane [GO:1903765]; negative regulation of potassium ion transmembrane transport [GO:1901380]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export across plasma membrane [GO:0097623]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of heart rate by hormone [GO:0003064]; regulation of membrane potential [GO:0042391]; regulation of membrane repolarization [GO:0060306]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:19412172, ECO:0000269|PubMed:26363003}; Multi-pass membrane protein {ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:19412172}.
Q12815	reviewed	TROAP_HUMAN	Tastin (Trophinin-assisting protein) (Trophinin-associated protein)	TROAP	Homo sapiens (Human)	778	FUNCTION: Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.		cell adhesion [GO:0007155]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cytoplasm.
Q12816	reviewed	TROP_HUMAN	Trophinin (MAGE-D3 antigen)	TRO KIAA1114 MAGED3	Homo sapiens (Human)	1431	FUNCTION: Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.		embryo implantation [GO:0007566]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]; plasma membrane [GO:0005886]		nucleus [GO:0005634]; plasma membrane [GO:0005886]; embryo implantation [GO:0007566]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
Q12824	reviewed	SNF5_HUMAN	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5)	SMARCB1 BAF47 INI1 SNF5L1	Homo sapiens (Human)	385	FUNCTION: Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. {ECO:0000250|UniProtKB:Q9Z0H3, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:12226744, ECO:0000269|PubMed:14604992, ECO:0000269|PubMed:16267391, ECO:0000269|PubMed:16314535, ECO:0000269|PubMed:9448295}.		blastocyst hatching [GO:0001835]; cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; DNA integration [GO:0015074]; hepatocyte differentiation [GO:0070365]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter [GO:1900461]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase I preinitiation complex assembly [GO:0001188]; single stranded viral RNA replication via double stranded DNA intermediate [GO:0039692]; transcription initiation-coupled chromatin remodeling [GO:0045815]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; fibrillar center [GO:0001650]; germ cell nucleus [GO:0043073]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; XY body [GO:0001741]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; fibrillar center [GO:0001650]; germ cell nucleus [GO:0043073]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; XY body [GO:0001741]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; blastocyst hatching [GO:0001835]; cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; DNA integration [GO:0015074]; hepatocyte differentiation [GO:0070365]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter [GO:1900461]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase I preinitiation complex assembly [GO:0001188]; single stranded viral RNA replication via double stranded DNA intermediate [GO:0039692]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus.
Q12830	reviewed	BPTF_HUMAN	Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen)	BPTF FAC1 FALZ	Homo sapiens (Human)	3046	FUNCTION: Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}.		anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; cellular response to nerve growth factor stimulus [GO:1990090]; chromatin remodeling [GO:0006338]; embryonic placenta development [GO:0001892]; endoderm development [GO:0007492]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	ATPase complex [GO:1904949]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]; perinuclear region of cytoplasm [GO:0048471]	metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	ATPase complex [GO:1904949]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]; perinuclear region of cytoplasm [GO:0048471]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; cellular response to nerve growth factor stimulus [GO:1990090]; chromatin remodeling [GO:0006338]; embryonic placenta development [GO:0001892]; endoderm development [GO:0007492]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15379550}. Nucleus {ECO:0000269|PubMed:10727212, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:9225734}. Note=Localizes to sites of DNA damage (PubMed:25593309). In brains of Alzheimer disease patients, present in a subset of amyloid-containing plaques (PubMed:10727212). {ECO:0000269|PubMed:10727212, ECO:0000269|PubMed:25593309}.
Q12834	reviewed	CDC20_HUMAN	Cell division cycle protein 20 homolog (p55CDC)	CDC20	Homo sapiens (Human)	499	FUNCTION: Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell differentiation [GO:0030154]; cell division [GO:0051301]; metaphase/anaphase transition of cell cycle [GO:0044784]; metaphase/anaphase transition of meiosis I [GO:1990949]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly [GO:0090307]; mitotic spindle assembly checkpoint signaling [GO:0007094]; nervous system development [GO:0007399]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of meiotic nuclear division [GO:0040020]; regulation of mitotic cell cycle [GO:0007346]	anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; spindle pole [GO:0000922]	anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757]	anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; spindle pole [GO:0000922]; anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell differentiation [GO:0030154]; cell division [GO:0051301]; metaphase/anaphase transition of cell cycle [GO:0044784]; metaphase/anaphase transition of meiosis I [GO:1990949]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly [GO:0090307]; mitotic spindle assembly checkpoint signaling [GO:0007094]; nervous system development [GO:0007399]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of meiotic nuclear division [GO:0040020]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20034488}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:33094908}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20034488}.
Q12836	reviewed	ZP4_HUMAN	Zona pellucida sperm-binding protein 4 (Zona pellucida glycoprotein 4) (Zp-4) (Zona pellucida protein B) [Cleaved into: Processed zona pellucida sperm-binding protein 4]	ZP4 ZPB	Homo sapiens (Human)	540	FUNCTION: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.		acrosomal vesicle exocytosis [GO:0060478]; binding of sperm to zona pellucida [GO:0007339]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of humoral immune response [GO:0002922]; positive regulation of T cell proliferation [GO:0042102]; prevention of polyspermy [GO:0060468]	collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	acrosin binding [GO:0032190]; identical protein binding [GO:0042802]; structural constituent of egg coat [GO:0035804]	collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; acrosin binding [GO:0032190]; identical protein binding [GO:0042802]; structural constituent of egg coat [GO:0035804]; acrosomal vesicle exocytosis [GO:0060478]; binding of sperm to zona pellucida [GO:0007339]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of humoral immune response [GO:0002922]; positive regulation of T cell proliferation [GO:0042102]; prevention of polyspermy [GO:0060468]	SUBCELLULAR LOCATION: [Processed zona pellucida sperm-binding protein 4]: Zona pellucida {ECO:0000250|UniProtKB:Q00193}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q00193}; Single-pass type I membrane protein {ECO:0000255}.
Q12837	reviewed	PO4F2_HUMAN	POU domain, class 4, transcription factor 2 (Brain-specific homeobox/POU domain protein 3B) (Brain-3B) (Brn-3B)	POU4F2 BRN3B	Homo sapiens (Human)	409	FUNCTION: Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:19266028, PubMed:23805044). Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:19266028, PubMed:23805044). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation (By similarity). {ECO:0000250|UniProtKB:Q63934, ECO:0000269|PubMed:19266028, ECO:0000269|PubMed:23805044}.		axon extension [GO:0048675]; axon guidance [GO:0007411]; cellular response to cytokine stimulus [GO:0071345]; cellular response to estradiol stimulus [GO:0071392]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxygen levels [GO:0071453]; dorsal root ganglion development [GO:1990791]; heart development [GO:0007507]; intracellular estrogen receptor signaling pathway [GO:0030520]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; MAPK cascade [GO:0000165]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of amacrine cell differentiation [GO:1902870]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuromuscular process controlling balance [GO:0050885]; neuron differentiation [GO:0030182]; positive regulation of axon extension [GO:0045773]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell differentiation [GO:0045597]; positive regulation of glucose import [GO:0046326]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of retinal ganglion cell axon guidance [GO:0090259]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; retinal ganglion cell axon guidance [GO:0031290]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; axon extension [GO:0048675]; axon guidance [GO:0007411]; cellular response to cytokine stimulus [GO:0071345]; cellular response to estradiol stimulus [GO:0071392]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxygen levels [GO:0071453]; dorsal root ganglion development [GO:1990791]; heart development [GO:0007507]; intracellular estrogen receptor signaling pathway [GO:0030520]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; MAPK cascade [GO:0000165]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of amacrine cell differentiation [GO:1902870]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuromuscular process controlling balance [GO:0050885]; neuron differentiation [GO:0030182]; positive regulation of axon extension [GO:0045773]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell differentiation [GO:0045597]; positive regulation of glucose import [GO:0046326]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of retinal ganglion cell axon guidance [GO:0090259]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; retinal ganglion cell axon guidance [GO:0031290]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7691107}. Nucleus speckle {ECO:0000269|PubMed:19266028}. Cytoplasm {ECO:0000250|UniProtKB:Q63934}.
Q12840	reviewed	KIF5A_HUMAN	Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC)	KIF5A NKHC1	Homo sapiens (Human)	1032	FUNCTION: Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. {ECO:0000250|UniProtKB:P33175, ECO:0000250|UniProtKB:Q6QLM7}.		anterograde axonal protein transport [GO:0099641]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; axon guidance [GO:0007411]; chemical synaptic transmission [GO:0007268]; microtubule-based movement [GO:0007018]; retrograde neuronal dense core vesicle transport [GO:1990049]; synaptic vesicle transport [GO:0048489]; vesicle-mediated transport [GO:0016192]	axon cytoplasm [GO:1904115]; ciliary rootlet [GO:0035253]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]	axon cytoplasm [GO:1904115]; ciliary rootlet [GO:0035253]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]; anterograde axonal protein transport [GO:0099641]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; axon guidance [GO:0007411]; chemical synaptic transmission [GO:0007268]; microtubule-based movement [GO:0007018]; retrograde neuronal dense core vesicle transport [GO:1990049]; synaptic vesicle transport [GO:0048489]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6QLM7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6QLM7}. Perikaryon {ECO:0000250|UniProtKB:Q6QLM7}. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region. {ECO:0000250|UniProtKB:Q6QLM7}.
Q12841	reviewed	FSTL1_HUMAN	Follistatin-related protein 1 (Follistatin-like protein 1)	FSTL1 FRP	Homo sapiens (Human)	308	FUNCTION: Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (PubMed:29212066, PubMed:22265692). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed:20054002, PubMed:22265692). {ECO:0000250|UniProtKB:Q62356, ECO:0000269|PubMed:20054002, ECO:0000269|PubMed:22265692, ECO:0000269|PubMed:29212066}.		cell differentiation [GO:0030154]; endothelial cell differentiation [GO:0045446]; endothelial cell migration [GO:0043542]; hematopoietic stem cell homeostasis [GO:0061484]; negative regulation of apoptotic process [GO:0043066]; regulation of BMP signaling pathway [GO:0030510]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; heparin binding [GO:0008201]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; cell differentiation [GO:0030154]; endothelial cell differentiation [GO:0045446]; endothelial cell migration [GO:0043542]; hematopoietic stem cell homeostasis [GO:0061484]; negative regulation of apoptotic process [GO:0043066]; regulation of BMP signaling pathway [GO:0030510]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q12846	reviewed	STX4_HUMAN	Syntaxin-4 (Renal carcinoma antigen NY-REN-31)	STX4 STX4A	Homo sapiens (Human)	297	FUNCTION: Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). {ECO:0000250|UniProtKB:P70452, ECO:0000250|UniProtKB:Q08850}.		cellular response to oxidative stress [GO:0034599]; cellular response to type II interferon [GO:0071346]; cornified envelope assembly [GO:1903575]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; long-term synaptic potentiation [GO:0060291]; neurotransmitter transport [GO:0006836]; organelle fusion [GO:0048284]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of eosinophil degranulation [GO:0043311]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to cell surface [GO:0034394]; regulation of exocytosis [GO:0017157]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; SNARE complex assembly [GO:0035493]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lateral loop [GO:0043219]; membrane [GO:0016020]; myelin sheath adaxonal region [GO:0035749]; neuron projection membrane [GO:0032589]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; SNARE complex [GO:0031201]; somatodendritic compartment [GO:0036477]; specific granule [GO:0042581]; storage vacuole [GO:0000322]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; sphingomyelin phosphodiesterase activator activity [GO:0016230]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lateral loop [GO:0043219]; membrane [GO:0016020]; myelin sheath adaxonal region [GO:0035749]; neuron projection membrane [GO:0032589]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; SNARE complex [GO:0031201]; somatodendritic compartment [GO:0036477]; specific granule [GO:0042581]; storage vacuole [GO:0000322]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; sphingomyelin phosphodiesterase activator activity [GO:0016230]; cellular response to oxidative stress [GO:0034599]; cellular response to type II interferon [GO:0071346]; cornified envelope assembly [GO:1903575]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; long-term synaptic potentiation [GO:0060291]; neurotransmitter transport [GO:0006836]; organelle fusion [GO:0048284]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of eosinophil degranulation [GO:0043311]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to cell surface [GO:0034394]; regulation of exocytosis [GO:0017157]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; SNARE complex assembly [GO:0035493]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q08850}; Single-pass type IV membrane protein {ECO:0000305}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q08850}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000250|UniProtKB:Q08850}.
Q12849	reviewed	GRSF1_HUMAN	G-rich sequence factor 1 (GRSF-1)	GRSF1	Homo sapiens (Human)	480	FUNCTION: Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381). {ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034, ECO:0000269|PubMed:29967381}.	MISCELLANEOUS: Depletion of GRSF1 by siRNA results in a combined OXPHOS assembly defect, with the prominent loss of complexes I, III, IV, and V. It also leads to altered steady-state levels of mitochondrial rRNAs and mRNAs.	anterior/posterior pattern specification [GO:0009952]; morphogenesis of embryonic epithelium [GO:0016331]; mRNA polyadenylation [GO:0006378]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; regulation of RNA splicing [GO:0043484]; tRNA processing [GO:0008033]	cytoplasm [GO:0005737]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; anterior/posterior pattern specification [GO:0009952]; morphogenesis of embryonic epithelium [GO:0016331]; mRNA polyadenylation [GO:0006378]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; regulation of RNA splicing [GO:0043484]; tRNA processing [GO:0008033]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion matrix {ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034, ECO:0000269|PubMed:25683715, ECO:0000269|PubMed:29967381}. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034, ECO:0000269|PubMed:25683715}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:23473034}.
Q12851	reviewed	M4K2_HUMAN	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)	MAP4K2 GCK RAB8IP	Homo sapiens (Human)	820	FUNCTION: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}.		immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; protein phosphorylation [GO:0006468]; vesicle targeting [GO:0006903]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]	ATP binding [GO:0005524]; MAP kinase kinase kinase kinase activity [GO:0008349]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; ATP binding [GO:0005524]; MAP kinase kinase kinase kinase activity [GO:0008349]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; protein phosphorylation [GO:0006468]; vesicle targeting [GO:0006903]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q12852	reviewed	M3K12_HUMAN	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)	MAP3K12 ZPK	Homo sapiens (Human)	859	FUNCTION: Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. {ECO:0000269|PubMed:28111074}.		intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; negative regulation of motor neuron apoptotic process [GO:2000672]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of protein kinase activity [GO:0045860]; post-translational protein modification [GO:0043687]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; negative regulation of motor neuron apoptotic process [GO:2000672]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of protein kinase activity [GO:0045860]; post-translational protein modification [GO:0043687]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q60700}. Cell membrane {ECO:0000250|UniProtKB:Q60700}. Note=Behaves essentially as an integral membrane protein. {ECO:0000250|UniProtKB:Q60700}.
Q12857	reviewed	NFIA_HUMAN	Nuclear factor 1 A-type (NF1-A) (Nuclear factor 1/A) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/A) (NF-I/A) (NFI-A) (TGGCA-binding protein)	NFIA KIAA1439	Homo sapiens (Human)	509	FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.		BMP signaling pathway [GO:0030509]; cartilage development [GO:0051216]; cell morphogenesis [GO:0000902]; DNA replication [GO:0006260]; exit from mitosis [GO:0010458]; gene expression [GO:0010467]; glial cell fate specification [GO:0021780]; glial cell proliferation [GO:0014009]; limb morphogenesis [GO:0035108]; neural precursor cell proliferation [GO:0061351]; neuron fate specification [GO:0048665]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; synapse maturation [GO:0060074]; ureter development [GO:0072189]; viral genome replication [GO:0019079]	cell junction [GO:0030054]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cell junction [GO:0030054]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; BMP signaling pathway [GO:0030509]; cartilage development [GO:0051216]; cell morphogenesis [GO:0000902]; DNA replication [GO:0006260]; exit from mitosis [GO:0010458]; gene expression [GO:0010467]; glial cell fate specification [GO:0021780]; glial cell proliferation [GO:0014009]; limb morphogenesis [GO:0035108]; neural precursor cell proliferation [GO:0061351]; neuron fate specification [GO:0048665]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; synapse maturation [GO:0060074]; ureter development [GO:0072189]; viral genome replication [GO:0019079]	SUBCELLULAR LOCATION: Nucleus.
Q12860	reviewed	CNTN1_HUMAN	Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3)	CNTN1	Homo sapiens (Human)	1018	FUNCTION: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; central nervous system myelin formation [GO:0032289]; cerebellum development [GO:0021549]; gene expression [GO:0010467]; locomotory behavior [GO:0007626]; Notch signaling pathway [GO:0007219]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sodium ion transport [GO:0010765]	axon [GO:0030424]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; side of membrane [GO:0098552]	carbohydrate binding [GO:0030246]; cell-cell adhesion mediator activity [GO:0098632]	axon [GO:0030424]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; side of membrane [GO:0098552]; carbohydrate binding [GO:0030246]; cell-cell adhesion mediator activity [GO:0098632]; axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; central nervous system myelin formation [GO:0032289]; cerebellum development [GO:0021549]; gene expression [GO:0010467]; locomotory behavior [GO:0007626]; Notch signaling pathway [GO:0007219]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sodium ion transport [GO:0010765]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Q12864	reviewed	CAD17_HUMAN	Cadherin-17 (Intestinal peptide-associated transporter HPT-1) (Liver-intestine cadherin) (LI-cadherin)	CDH17	Homo sapiens (Human)	832	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. {ECO:0000269|PubMed:8153632}.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; germinal center B cell differentiation [GO:0002314]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; integrin-mediated signaling pathway [GO:0007229]; marginal zone B cell differentiation [GO:0002315]; oligopeptide transmembrane transport [GO:0035672]; oligopeptide transport [GO:0006857]; positive regulation of integrin activation by cell surface receptor linked signal transduction [GO:0033626]; spleen development [GO:0048536]	adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; proton-dependent oligopeptide secondary active transmembrane transporter activity [GO:0005427]	adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; proton-dependent oligopeptide secondary active transmembrane transporter activity [GO:0005427]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; germinal center B cell differentiation [GO:0002314]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; integrin-mediated signaling pathway [GO:0007229]; marginal zone B cell differentiation [GO:0002315]; oligopeptide transmembrane transport [GO:0035672]; oligopeptide transport [GO:0006857]; positive regulation of integrin activation by cell surface receptor linked signal transduction [GO:0033626]; spleen development [GO:0048536]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q12866	reviewed	MERTK_HUMAN	Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)	MERTK MER	Homo sapiens (Human)	999	FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment (PubMed:32640697). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:32640697}.		cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; establishment of localization in cell [GO:0051649]; natural killer cell differentiation [GO:0001779]; negative regulation of cytokine production [GO:0001818]; negative regulation of leukocyte apoptotic process [GO:2000107]; negative regulation of lymphocyte activation [GO:0051250]; nervous system development [GO:0007399]; neutrophil clearance [GO:0097350]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet activation [GO:0030168]; positive regulation of phagocytosis [GO:0050766]; protein phosphorylation [GO:0006468]; retina development in camera-type eye [GO:0060041]; secretion by cell [GO:0032940]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vagina development [GO:0060068]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; establishment of localization in cell [GO:0051649]; natural killer cell differentiation [GO:0001779]; negative regulation of cytokine production [GO:0001818]; negative regulation of leukocyte apoptotic process [GO:2000107]; negative regulation of lymphocyte activation [GO:0051250]; nervous system development [GO:0007399]; neutrophil clearance [GO:0097350]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet activation [GO:0030168]; positive regulation of phagocytosis [GO:0050766]; protein phosphorylation [GO:0006468]; retina development in camera-type eye [GO:0060041]; secretion by cell [GO:0032940]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vagina development [GO:0060068]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32640697}; Single-pass type I membrane protein {ECO:0000250}.
Q12870	reviewed	TCF15_HUMAN	Transcription factor 15 (TCF-15) (Class A basic helix-loop-helix protein 40) (bHLHa40) (Paraxis) (Protein bHLH-EC2)	TCF15 BHLHA40 BHLHEC2	Homo sapiens (Human)	199	FUNCTION: Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal. Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells. Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes. {ECO:0000250|UniProtKB:Q60756}.		developmental process [GO:0032502]; ear development [GO:0043583]; establishment of epithelial cell apical/basal polarity [GO:0045198]; mesenchymal to epithelial transition [GO:0060231]; mesoderm development [GO:0007498]; muscle organ morphogenesis [GO:0048644]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; neuromuscular process controlling posture [GO:0050884]; paraxial mesoderm development [GO:0048339]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; regulation of extracellular matrix organization [GO:1903053]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory system process [GO:0003016]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; stem cell population maintenance [GO:0019827]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; developmental process [GO:0032502]; ear development [GO:0043583]; establishment of epithelial cell apical/basal polarity [GO:0045198]; mesenchymal to epithelial transition [GO:0060231]; mesoderm development [GO:0007498]; muscle organ morphogenesis [GO:0048644]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; neuromuscular process controlling posture [GO:0050884]; paraxial mesoderm development [GO:0048339]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; regulation of extracellular matrix organization [GO:1903053]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory system process [GO:0003016]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q60756, ECO:0000255|PROSITE-ProRule:PRU00981}.
Q12873	reviewed	CHD3_HUMAN	Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.12) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH)	CHD3	Homo sapiens (Human)	2000	FUNCTION: ATP-dependent helicase that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:9804427, PubMed:30397230, PubMed:16428440, PubMed:28977666). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}.	MISCELLANEOUS: One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis. {ECO:0000269|PubMed:7560064}.	centrosome cycle [GO:0007098]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; spindle organization [GO:0007051]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; PML body [GO:0016605]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; PML body [GO:0016605]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; centrosome cycle [GO:0007098]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000269|PubMed:27068747}. Nucleus {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17626165}. Note=Associates with centrosomes in interphase and mitosis (PubMed:17626165). Localizes to sites of DNA damage (PubMed:28977666). {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:28977666}.
Q12874	reviewed	SF3A3_HUMAN	Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61)	SF3A3 SAP61	Homo sapiens (Human)	501	FUNCTION: Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:8022796, PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:8022796}.		mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:8022796}. Nucleus {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:21349847, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277}.
Q12879	reviewed	NMDE1_HUMAN	Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)	GRIN2A NMDAR2A	Homo sapiens (Human)	1464	FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:Q00959, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:8768735}.		activation of cysteine-type endopeptidase activity [GO:0097202]; brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; chemical synaptic transmission [GO:0007268]; directional locomotion [GO:0033058]; dopamine metabolic process [GO:0042417]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of protein catabolic process [GO:0042177]; neurogenesis [GO:0022008]; positive regulation of apoptotic process [GO:0043065]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein catabolic process [GO:0030163]; protein localization to postsynaptic membrane [GO:1903539]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to amphetamine [GO:0001975]; response to ethanol [GO:0045471]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; serotonin metabolic process [GO:0042428]; sleep [GO:0030431]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]; visual learning [GO:0008542]	cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]	amyloid-beta binding [GO:0001540]; glutamate-gated calcium ion channel activity [GO:0022849]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; amyloid-beta binding [GO:0001540]; glutamate-gated calcium ion channel activity [GO:0022849]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; zinc ion binding [GO:0008270]; activation of cysteine-type endopeptidase activity [GO:0097202]; brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; chemical synaptic transmission [GO:0007268]; directional locomotion [GO:0033058]; dopamine metabolic process [GO:0042417]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of protein catabolic process [GO:0042177]; neurogenesis [GO:0022008]; positive regulation of apoptotic process [GO:0043065]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein catabolic process [GO:0030163]; protein localization to postsynaptic membrane [GO:1903539]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to amphetamine [GO:0001975]; response to ethanol [GO:0045471]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; serotonin metabolic process [GO:0042428]; sleep [GO:0030431]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q00959}. Cell membrane {ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:8768735}; Multi-pass membrane protein {ECO:0000305}. Synapse {ECO:0000250|UniProtKB:P35436}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00959}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P35436}. Note=Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. {ECO:0000250|UniProtKB:P35436}.
Q12882	reviewed	DPYD_HUMAN	Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)	DPYD	Homo sapiens (Human)	1025	FUNCTION: Involved in pyrimidine base degradation (PubMed:1512248). Catalyzes the reduction of uracil and thymine (PubMed:1512248). Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (PubMed:1512248). {ECO:0000269|PubMed:1512248}.		beta-alanine biosynthetic process [GO:0019483]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dUMP catabolic process [GO:0046079]; purine nucleobase catabolic process [GO:0006145]; pyrimidine nucleobase catabolic process [GO:0006208]; thymidine catabolic process [GO:0006214]; thymine catabolic process [GO:0006210]; UMP catabolic process [GO:0046050]; uracil catabolic process [GO:0006212]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	4 iron, 4 sulfur cluster binding [GO:0051539]; dihydropyrimidine dehydrogenase (NADP+) activity [GO:0017113]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; uracil binding [GO:0002058]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; dihydropyrimidine dehydrogenase (NADP+) activity [GO:0017113]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; uracil binding [GO:0002058]; beta-alanine biosynthetic process [GO:0019483]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dUMP catabolic process [GO:0046079]; purine nucleobase catabolic process [GO:0006145]; pyrimidine nucleobase catabolic process [GO:0006208]; thymidine catabolic process [GO:0006214]; thymine catabolic process [GO:0006210]; UMP catabolic process [GO:0046050]; uracil catabolic process [GO:0006212]	SUBCELLULAR LOCATION: Cytoplasm.
Q12884	reviewed	SEPR_HUMAN	Prolyl endopeptidase FAP (EC 3.4.21.26) (170 kDa melanoma membrane-bound gelatinase) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)]	FAP	Homo sapiens (Human)	760	FUNCTION: Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vitronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Also has dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16651416, PubMed:16410248, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner. {ECO:0000250|UniProtKB:P97321, ECO:0000269|PubMed:10347120, ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:16223769, ECO:0000269|PubMed:16410248, ECO:0000269|PubMed:16480718, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:17381073, ECO:0000269|PubMed:18095711, ECO:0000269|PubMed:20707604, ECO:0000269|PubMed:21288888, ECO:0000269|PubMed:21314817, ECO:0000269|PubMed:2172980, ECO:0000269|PubMed:24371721, ECO:0000269|PubMed:24717288, ECO:0000269|PubMed:7923219, ECO:0000269|PubMed:9065413}.	MISCELLANEOUS: [Isoform 1]: Major isoform.; MISCELLANEOUS: [Isoform 2]: Upstream open reading frames ORF(s)-containing region inhibits the translation of its downstream ORF. {ECO:0000269|PubMed:10644713}.	angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; endothelial cell migration [GO:0043542]; melanocyte apoptotic process [GO:1902362]; melanocyte proliferation [GO:0097325]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of extracellular matrix organization [GO:1903054]; positive regulation of execution phase of apoptosis [GO:1900119]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cell cycle [GO:0051726]; regulation of collagen catabolic process [GO:0010710]; regulation of fibrinolysis [GO:0051917]	apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; peptidase complex [GO:1905368]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	dipeptidyl-peptidase activity [GO:0008239]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; peptidase complex [GO:1905368]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; dipeptidyl-peptidase activity [GO:0008239]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; endothelial cell migration [GO:0043542]; melanocyte apoptotic process [GO:1902362]; melanocyte proliferation [GO:0097325]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of extracellular matrix organization [GO:1903054]; positive regulation of execution phase of apoptosis [GO:1900119]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cell cycle [GO:0051726]; regulation of collagen catabolic process [GO:0010710]; regulation of fibrinolysis [GO:0051917]	SUBCELLULAR LOCATION: [Prolyl endopeptidase FAP]: Cell surface {ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:24717288, ECO:0000269|PubMed:7911242}. Cell membrane {ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:9065413, ECO:0000303|PubMed:10455171}; Single-pass type II membrane protein {ECO:0000255}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:9065413}; Single-pass type II membrane protein {ECO:0000255}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:7923219, ECO:0000269|PubMed:9065413, ECO:0000303|PubMed:10455171}; Single-pass type II membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000303|PubMed:10455171}; Single-pass type II membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:2172980}; Single-pass type II membrane protein {ECO:0000255}. Note=Localized on cell surface with lamellipodia and invadopodia membranes and on shed vesicles. Colocalized with DPP4 at invadopodia and lamellipodia membranes of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Anchored and enriched preferentially by integrin alpha-3/beta-1 at invadopodia, plasma membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. Colocalized with PLAUR preferentially at the cell surface of invadopodia membranes in a cytoskeleton-, integrin- and vitronectin-dependent manner. Concentrated at invadopodia membranes, specialized protrusions of the ventral plasma membrane in a fibrobectin-dependent manner. Colocalizes with extracellular components (ECM), such as collagen fibers and fibronectin. {ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:2172980, ECO:0000269|PubMed:24717288, ECO:0000269|PubMed:7911242, ECO:0000269|PubMed:7923219, ECO:0000269|PubMed:9065413, ECO:0000303|PubMed:10455171}.; SUBCELLULAR LOCATION: [Antiplasmin-cleaving enzyme FAP, soluble form]: Secreted {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769, ECO:0000269|PubMed:24371721}. Note=Found in blood plasma and serum. {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769, ECO:0000269|PubMed:24371721}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000303|PubMed:10644713}.
Q12887	reviewed	COX10_HUMAN	Protoheme IX farnesyltransferase, mitochondrial (EC 2.5.1.141) (Heme O synthase)	COX10	Homo sapiens (Human)	443	FUNCTION: Converts protoheme IX and farnesyl diphosphate to heme O. {ECO:0000250}.		aerobic respiration [GO:0009060]; heme A biosynthetic process [GO:0006784]; heme biosynthetic process [GO:0006783]; lipid metabolic process [GO:0006629]; mitochondrial fission [GO:0000266]; respiratory chain complex IV assembly [GO:0008535]	cytochrome complex [GO:0070069]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	farnesyltranstransferase activity [GO:0004311]; protoheme IX farnesyltransferase activity [GO:0008495]	cytochrome complex [GO:0070069]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; farnesyltranstransferase activity [GO:0004311]; protoheme IX farnesyltransferase activity [GO:0008495]; aerobic respiration [GO:0009060]; heme A biosynthetic process [GO:0006784]; heme biosynthetic process [GO:0006783]; lipid metabolic process [GO:0006629]; mitochondrial fission [GO:0000266]; respiratory chain complex IV assembly [GO:0008535]	SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane protein.
Q12888	reviewed	TP53B_HUMAN	TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)	TP53BP1	Homo sapiens (Human)	1972	FUNCTION: Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:27153538, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306, PubMed:27153538). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:27153538, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136}.		cellular response to X-ray [GO:0071481]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of isotype switching [GO:0045830]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; DNA repair complex [GO:1990391]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]	damaged DNA binding [GO:0003684]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; telomeric DNA binding [GO:0042162]; transcription coregulator activity [GO:0003712]; ubiquitin modification-dependent histone binding [GO:0061649]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; DNA repair complex [GO:1990391]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]; damaged DNA binding [GO:0003684]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; telomeric DNA binding [GO:0042162]; transcription coregulator activity [GO:0003712]; ubiquitin modification-dependent histone binding [GO:0061649]; cellular response to X-ray [GO:0071481]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of isotype switching [GO:0045830]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11331310, ECO:0000269|PubMed:15525939, ECO:0000269|PubMed:16294045, ECO:0000269|PubMed:16294047, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:19176521, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:9748285}. Chromosome {ECO:0000269|PubMed:12824158, ECO:0000269|PubMed:15525939, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:24703952, ECO:0000269|PubMed:28241136}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P70399}. Note=Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:28241136}.
Q12889	reviewed	OVGP1_HUMAN	Oviduct-specific glycoprotein (Estrogen-dependent oviduct protein) (Mucin-9) (Oviductal glycoprotein) (Oviductin)	OVGP1 MUC9 OGP	Homo sapiens (Human)	678	FUNCTION: Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.		carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; female pregnancy [GO:0007565]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; single fertilization [GO:0007338]	cytosol [GO:0005829]; egg coat [GO:0035805]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; microtubule cytoskeleton [GO:0015630]; perivitelline space [GO:0098595]; transport vesicle [GO:0030133]	chitin binding [GO:0008061]; chitinase activity [GO:0004568]	cytosol [GO:0005829]; egg coat [GO:0035805]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; microtubule cytoskeleton [GO:0015630]; perivitelline space [GO:0098595]; transport vesicle [GO:0030133]; chitin binding [GO:0008061]; chitinase activity [GO:0004568]; carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; female pregnancy [GO:0007565]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules.
Q12891	reviewed	HYAL2_HUMAN	Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2)	HYAL2 LUCA2	Homo sapiens (Human)	473	FUNCTION: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. {ECO:0000269|PubMed:11296287, ECO:0000269|PubMed:12676986, ECO:0000269|PubMed:9712871}.		carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; defense response to virus [GO:0051607]; fusion of virus membrane with host plasma membrane [GO:0019064]; glycosaminoglycan catabolic process [GO:0006027]; hematopoietic progenitor cell differentiation [GO:0002244]; hyaluronan catabolic process [GO:0030214]; kidney development [GO:0001822]; monocyte activation [GO:0042117]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of cell growth [GO:0030308]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of urine volume [GO:0035810]; renal water absorption [GO:0070295]; response to antibiotic [GO:0046677]; response to reactive oxygen species [GO:0000302]; response to virus [GO:0009615]; skeletal system morphogenesis [GO:0048705]; viral entry into host cell [GO:0046718]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; membrane raft [GO:0045121]; microvillus [GO:0005902]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]	enzyme binding [GO:0019899]; hyaluronic acid binding [GO:0005540]; hyaluronoglucuronidase activity [GO:0033906]; hyalurononglucosaminidase activity [GO:0004415]; receptor signaling protein tyrosine kinase inhibitor activity [GO:0030294]; receptor tyrosine kinase binding [GO:0030971]; transcription coactivator activity [GO:0003713]; transforming growth factor beta binding [GO:0050431]; virus receptor activity [GO:0001618]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; membrane raft [GO:0045121]; microvillus [GO:0005902]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]; enzyme binding [GO:0019899]; hyaluronic acid binding [GO:0005540]; hyaluronoglucuronidase activity [GO:0033906]; hyalurononglucosaminidase activity [GO:0004415]; receptor signaling protein tyrosine kinase inhibitor activity [GO:0030294]; receptor tyrosine kinase binding [GO:0030971]; transcription coactivator activity [GO:0003713]; transforming growth factor beta binding [GO:0050431]; virus receptor activity [GO:0001618]; carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; defense response to virus [GO:0051607]; fusion of virus membrane with host plasma membrane [GO:0019064]; glycosaminoglycan catabolic process [GO:0006027]; hematopoietic progenitor cell differentiation [GO:0002244]; hyaluronan catabolic process [GO:0030214]; kidney development [GO:0001822]; monocyte activation [GO:0042117]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of cell growth [GO:0030308]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of urine volume [GO:0035810]; renal water absorption [GO:0070295]; response to antibiotic [GO:0046677]; response to reactive oxygen species [GO:0000302]; response to virus [GO:0009615]; skeletal system morphogenesis [GO:0048705]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11296287}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11296287}.
Q12893	reviewed	TM115_HUMAN	Transmembrane protein 115 (Placental protein 6) (Protein PL6)	TMEM115 PL6 LUCA11.2	Homo sapiens (Human)	351	FUNCTION: May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. {ECO:0000269|PubMed:24806965}.		negative regulation of cell population proliferation [GO:0008285]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; negative regulation of cell population proliferation [GO:0008285]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:17973242, ECO:0000269|PubMed:24806965}; Multi-pass membrane protein {ECO:0000303|PubMed:24806965}.
Q12899	reviewed	TRI26_HUMAN	Tripartite motif-containing protein 26 (EC 2.3.2.27) (Acid finger protein) (AFP) (RING finger protein 95) (Zinc finger protein 173)	TRIM26 RNF95 ZNF173	Homo sapiens (Human)	539	FUNCTION: E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Plays also a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA (PubMed:29610152, PubMed:36232914). Promotes nuclear IRF3 ubiquitination and proteasomal degradation (PubMed:25763818). Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling (PubMed:34017102). In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation (PubMed:34732716). Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein (PubMed:23452852). Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (PubMed:29203640). Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity). Inhibits directly hepatitis B virus replication by mediating HBX ubiquitination and subsequent degradation (PubMed:35872575). {ECO:0000250|UniProtKB:Q99PN3, ECO:0000269|PubMed:23452852, ECO:0000269|PubMed:25763818, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:29203640, ECO:0000269|PubMed:29610152, ECO:0000269|PubMed:34017102, ECO:0000269|PubMed:34732716, ECO:0000269|PubMed:35872575, ECO:0000269|PubMed:36232914}.; FUNCTION: (Microbial infection) Promotes herpes simplex virus type 2/HHV-2 infection in vaginal epithelial cells by decreasing the nuclear localization of IRF3, the primary mediator of type I interferon activation. {ECO:0000269|PubMed:33419081}.		innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25763818, ECO:0000269|PubMed:34017102, ECO:0000269|PubMed:35872575}. Nucleus {ECO:0000269|PubMed:25763818, ECO:0000269|PubMed:33419081}. Note=Viral infection mediates TRIM26 nuclear translocation. {ECO:0000269|PubMed:25763818}.
Q12904	reviewed	AIMP1_HUMAN	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)]	AIMP1 EMAP2 SCYE1	Homo sapiens (Human)	312	FUNCTION: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550). {ECO:0000250|UniProtKB:P31230, ECO:0000269|PubMed:10358004, ECO:0000269|PubMed:11157763, ECO:0000269|PubMed:11306575, ECO:0000269|PubMed:11818442, ECO:0000269|PubMed:12237313, ECO:0000269|PubMed:19362550}.		angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; leukocyte migration [GO:0050900]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of glucagon secretion [GO:0070094]; translation [GO:0006412]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]	cytokine activity [GO:0005125]; GTPase binding [GO:0051020]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; cytokine activity [GO:0005125]; GTPase binding [GO:0051020]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; leukocyte migration [GO:0050900]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of glucagon secretion [GO:0070094]; translation [GO:0006412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14500886}. Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}. Secreted {ECO:0000269|PubMed:10850427}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P31230}. Golgi apparatus {ECO:0000250|UniProtKB:P31230}. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Secreted in response to hypoxia (PubMed:10850427). Also secreted in response to both apoptotic and necrotic cell death. {ECO:0000250|UniProtKB:P31230, ECO:0000269|PubMed:10850427}.
Q12905	reviewed	ILF2_HUMAN	Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa)	ILF2 NF45 PRO3063	Homo sapiens (Human)	390	FUNCTION: Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:18458058, PubMed:31212927). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay (PubMed:32433969). Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71. {ECO:0000269|PubMed:10574923, ECO:0000269|PubMed:11739746, ECO:0000269|PubMed:18458058, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:31212927, ECO:0000269|PubMed:32433969, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}.		positive regulation of DNA-templated transcription [GO:0045893]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723]; positive regulation of DNA-templated transcription [GO:0045893]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm {ECO:0000269|PubMed:31212927, ECO:0000269|PubMed:31878072}. Nucleus {ECO:0000269|PubMed:31878072}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Q12906	reviewed	ILF3_HUMAN	Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80)	ILF3 DRBF MPHOSPH4 NF90	Homo sapiens (Human)	894	FUNCTION: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}.	MISCELLANEOUS: [Isoform 3]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.	defense response to virus [GO:0051607]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; virus receptor activity [GO:0001618]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; virus receptor activity [GO:0001618]; defense response to virus [GO:0051607]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:26240280}. Cytoplasm {ECO:0000269|PubMed:28625552}. Nucleus {ECO:0000269|PubMed:10749851, ECO:0000269|PubMed:26240280, ECO:0000269|PubMed:28625552}. Note=Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:21123651}.
Q12907	reviewed	LMAN2_HUMAN	Vesicular integral-membrane protein VIP36 (Glycoprotein GP36b) (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36)	LMAN2 C5orf8	Homo sapiens (Human)	356	FUNCTION: Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). {ECO:0000250}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of phagocytosis [GO:0050766]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cell surface [GO:0009986]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; heat shock protein binding [GO:0031072]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]	cell surface [GO:0009986]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; heat shock protein binding [GO:0031072]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of phagocytosis [GO:0050766]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:10444376}; Single-pass type I membrane protein {ECO:0000269|PubMed:10444376}. Golgi apparatus membrane {ECO:0000269|PubMed:10444376}; Single-pass membrane protein {ECO:0000269|PubMed:10444376}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10444376}; Single-pass type I membrane protein {ECO:0000269|PubMed:10444376}.
Q12908	reviewed	NTCP2_HUMAN	Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2)	SLC10A2 ASBT ISBT NTCP2	Homo sapiens (Human)	348	FUNCTION: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:7592981, PubMed:9458785, PubMed:9856990). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:7592981, PubMed:9458785, PubMed:9856990). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321). {ECO:0000269|PubMed:7592981, ECO:0000269|PubMed:9458785, ECO:0000269|PubMed:9856990, ECO:0000303|PubMed:33222321, ECO:0000305|PubMed:9458785}.		bile acid and bile salt transport [GO:0015721]; response to bacterium [GO:0009617]	apical plasma membrane [GO:0016324]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	bile acid:sodium symporter activity [GO:0008508]	apical plasma membrane [GO:0016324]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; bile acid:sodium symporter activity [GO:0008508]; bile acid and bile salt transport [GO:0015721]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q12912	reviewed	IRAG2_HUMAN	Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2]	IRAG2 JAW1 LRMP	Homo sapiens (Human)	555	FUNCTION: Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. {ECO:0000250|UniProtKB:Q60664}.		immune system process [GO:0002376]; nucleus organization [GO:0006997]; single fertilization [GO:0007338]; vesicle fusion [GO:0006906]; vesicle targeting [GO:0006903]	azurophil granule membrane [GO:0035577]; chromosome [GO:0005694]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]	microtubule binding [GO:0008017]	azurophil granule membrane [GO:0035577]; chromosome [GO:0005694]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]; microtubule binding [GO:0008017]; immune system process [GO:0002376]; nucleus organization [GO:0006997]; single fertilization [GO:0007338]; vesicle fusion [GO:0006906]; vesicle targeting [GO:0006903]	SUBCELLULAR LOCATION: [Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm {ECO:0000250|UniProtKB:Q60664}.; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q60664}; Single-pass type IV membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q60664}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5RHB5}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q5RHB5}. Chromosome {ECO:0000250|UniProtKB:Q5RHB5}. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q60664}.
Q12913	reviewed	PTPRJ_HUMAN	Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)	PTPRJ DEP1	Homo sapiens (Human)	1337	FUNCTION: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:12475979, PubMed:18348712, PubMed:19494114, PubMed:19922411, PubMed:21262971). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:12370829, PubMed:14709717, PubMed:16682945, PubMed:19836242). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (PubMed:16682945). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:21091576). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (PubMed:18936167). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (PubMed:19836242). Enhances the barrier function of epithelial junctions during reassembly (PubMed:19332538). Negatively regulates T-cell receptor (TCR) signaling (PubMed:9531590, PubMed:9780142, PubMed:11259588). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:11259588, PubMed:12913111). {ECO:0000250|UniProtKB:Q64455, ECO:0000269|PubMed:10821867, ECO:0000269|PubMed:11259588, ECO:0000269|PubMed:12062403, ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:14709717, ECO:0000269|PubMed:16682945, ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19922411, ECO:0000269|PubMed:21091576, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:9531590, ECO:0000269|PubMed:9780142}.; FUNCTION: [Isoform 2]: Activates angiogenesis and cell migration (PubMed:28052032). Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 (PubMed:28052032). {ECO:0000269|PubMed:28052032}.	MISCELLANEOUS: [Isoform 2]: Expressed in several normal and cancer cell lines, including A549, HUVEC, MCF7, HeLa, A172 and ADF cells (at protein level) (PubMed:28052032). Up-regulated in high-grade glioma samples (PubMed:28052032). {ECO:0000269|PubMed:28052032}.	B cell differentiation [GO:0030183]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; contact inhibition [GO:0060242]; cytokine-mediated signaling pathway [GO:0019221]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of vascular permeability [GO:0043116]; peptidyl-tyrosine dephosphorylation [GO:0035335]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive chemotaxis [GO:0050918]; positive regulation of cell adhesion [GO:0045785]; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell adhesion [GO:0030155]; T cell receptor signaling pathway [GO:0050852]	cell surface [GO:0009986]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; specific granule membrane [GO:0035579]	beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; mitogen-activated protein kinase binding [GO:0051019]; phosphatase activity [GO:0016791]; platelet-derived growth factor receptor binding [GO:0005161]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]	cell surface [GO:0009986]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; specific granule membrane [GO:0035579]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; mitogen-activated protein kinase binding [GO:0051019]; phosphatase activity [GO:0016791]; platelet-derived growth factor receptor binding [GO:0005161]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; B cell differentiation [GO:0030183]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; contact inhibition [GO:0060242]; cytokine-mediated signaling pathway [GO:0019221]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of vascular permeability [GO:0043116]; peptidyl-tyrosine dephosphorylation [GO:0035335]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive chemotaxis [GO:0050918]; positive regulation of cell adhesion [GO:0045785]; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell adhesion [GO:0030155]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane {ECO:0000250}. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted, extracellular space {ECO:0000269|PubMed:28052032}.
Q12918	reviewed	KLRB1_HUMAN	Killer cell lectin-like receptor subfamily B member 1 (C-type lectin domain family 5 member B) (HNKR-P1a) (NKR-P1A) (Natural killer cell surface protein P1A) (CD antigen CD161)	KLRB1 CLEC5B NKRP1A	Homo sapiens (Human)	225	FUNCTION: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. {ECO:0000269|PubMed:16455998, ECO:0000269|PubMed:16925668, ECO:0000269|PubMed:8077657}.		cell surface receptor signaling pathway [GO:0007166]; regulation of natural killer cell mediated cytotoxicity [GO:0042269]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; regulation of natural killer cell mediated cytotoxicity [GO:0042269]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q12923	reviewed	PTN13_HUMAN	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1)	PTPN13 PNP1 PTP1E PTPL1	Homo sapiens (Human)	2485	FUNCTION: Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}.	MISCELLANEOUS: [Isoform 4]: May be due to a competing donor splice site. {ECO:0000305}.	cellular response to toxic substance [GO:0097237]; negative regulation of excitatory synapse assembly [GO:1904890]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein tyrosine phosphatase activity [GO:0004725]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein tyrosine phosphatase activity [GO:0004725]; cellular response to toxic substance [GO:0097237]; negative regulation of excitatory synapse assembly [GO:1904890]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11356191}. Nucleus {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:11356191}. Cell projection, lamellipodium {ECO:0000269|PubMed:11356191}. Note=Colocalizes with F-actin (PubMed:10826496). Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover (PubMed:11356191). {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:11356191}.
Q12929	reviewed	EPS8_HUMAN	Epidermal growth factor receptor kinase substrate 8	EPS8	Homo sapiens (Human)	822	FUNCTION: Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}.		actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149]; cellular response to leukemia inhibitory factor [GO:1990830]; dendritic cell migration [GO:0036336]; exit from mitosis [GO:0010458]; positive regulation of ruffle assembly [GO:1900029]; Rac protein signal transduction [GO:0016601]; regulation of actin filament length [GO:0030832]; regulation of cell shape [GO:0008360]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]	brush border [GO:0005903]; cell cortex [GO:0005938]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; vesicle [GO:0031982]	actin binding [GO:0003779]; small GTPase binding [GO:0031267]	brush border [GO:0005903]; cell cortex [GO:0005938]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; vesicle [GO:0031982]; actin binding [GO:0003779]; small GTPase binding [GO:0031267]; actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149]; cellular response to leukemia inhibitory factor [GO:1990830]; dendritic cell migration [GO:0036336]; exit from mitosis [GO:0010458]; positive regulation of ruffle assembly [GO:1900029]; Rac protein signal transduction [GO:0016601]; regulation of actin filament length [GO:0030832]; regulation of cell shape [GO:0008360]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, stereocilium {ECO:0000250, ECO:0000250|UniProtKB:Q08509}. Synapse, synaptosome {ECO:0000250}. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells (By similarity). Localizes to the midzone of dividing cells. {ECO:0000250, ECO:0000250|UniProtKB:Q08509}.
Q12931	reviewed	TRAP1_HUMAN	Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)	TRAP1 HSP75	Homo sapiens (Human)	704	FUNCTION: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}.		chaperone-mediated protein folding [GO:0061077]; negative regulation of cellular respiration [GO:1901856]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; protein folding [GO:0006457]; translational attenuation [GO:0009386]	cell periphery [GO:0071944]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; tumor necrosis factor receptor binding [GO:0005164]; unfolded protein binding [GO:0051082]	cell periphery [GO:0071944]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; tumor necrosis factor receptor binding [GO:0005164]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]; negative regulation of cellular respiration [GO:1901856]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; protein folding [GO:0006457]; translational attenuation [GO:0009386]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23564345}. Mitochondrion inner membrane {ECO:0000269|PubMed:23564345}. Mitochondrion matrix {ECO:0000269|PubMed:23564345}.
Q12933	reviewed	TRAF2_HUMAN	TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)	TRAF2 TRAP3	Homo sapiens (Human)	501	FUNCTION: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis (PubMed:22212761). Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. {ECO:0000269|PubMed:10346818, ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:11907583, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:18981220, ECO:0000269|PubMed:19150425, ECO:0000269|PubMed:19506082, ECO:0000269|PubMed:19810754, ECO:0000269|PubMed:19918265, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20047764, ECO:0000269|PubMed:20064526, ECO:0000269|PubMed:20385093, ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:22212761, ECO:0000269|PubMed:23453969}.		activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to nitric oxide [GO:0071732]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mRNA stabilization [GO:0048255]; negative regulation of glial cell apoptotic process [GO:0034351]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein K63-linked ubiquitination [GO:0070534]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of immunoglobulin production [GO:0002637]; regulation of JNK cascade [GO:0046328]; regulation of protein-containing complex assembly [GO:0043254]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; signal transduction involved in regulation of gene expression [GO:0023019]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	CD40 receptor complex [GO:0035631]; cell cortex [GO:0005938]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IRE1-TRAF2-ASK1 complex [GO:1990604]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; TRAF2-GSTP1 complex [GO:0097057]; tumor necrosis factor receptor superfamily complex [GO:0002947]; ubiquitin ligase complex [GO:0000151]; vesicle membrane [GO:0012506]	CD40 receptor binding [GO:0005174]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; sphingolipid binding [GO:0046625]; thioesterase binding [GO:0031996]; tumor necrosis factor binding [GO:0043120]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cell cortex [GO:0005938]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IRE1-TRAF2-ASK1 complex [GO:1990604]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; TRAF2-GSTP1 complex [GO:0097057]; tumor necrosis factor receptor superfamily complex [GO:0002947]; ubiquitin ligase complex [GO:0000151]; vesicle membrane [GO:0012506]; CD40 receptor binding [GO:0005174]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; sphingolipid binding [GO:0046625]; thioesterase binding [GO:0031996]; tumor necrosis factor binding [GO:0043120]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to nitric oxide [GO:0071732]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mRNA stabilization [GO:0048255]; negative regulation of glial cell apoptotic process [GO:0034351]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein K63-linked ubiquitination [GO:0070534]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of immunoglobulin production [GO:0002637]; regulation of JNK cascade [GO:0046328]; regulation of protein-containing complex assembly [GO:0043254]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; signal transduction involved in regulation of gene expression [GO:0023019]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:19150425}.
Q12934	reviewed	BFSP1_HUMAN	Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H) [Cleaved into: Filensin C-terminal fragment; Filensin N-terminal fragment]	BFSP1	Homo sapiens (Human)	665	FUNCTION: Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:28935373). Involved in altering the calcium regulation of MIP water permeability (PubMed:30790544). {ECO:0000269|PubMed:28935373, ECO:0000269|PubMed:30790544}.		cell maturation [GO:0048469]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886]	structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212]; cell maturation [GO:0048469]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q06002}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q06002}; Cytoplasmic side {ECO:0000250|UniProtKB:Q06002}. Cytoplasm {ECO:0000250|UniProtKB:Q02435}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q06002}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q06002}.
Q12946	reviewed	FOXF1_HUMAN	Forkhead box protein F1 (Forkhead-related activator 1) (FREAC-1) (Forkhead-related protein FKHL5) (Forkhead-related transcription factor 1)	FOXF1 FKHL5 FREAC1	Homo sapiens (Human)	379	FUNCTION: Probable transcription activator for a number of lung-specific genes.		animal organ morphogenesis [GO:0009887]; blood vessel development [GO:0001568]; cardiac left ventricle morphogenesis [GO:0003214]; cell-cell adhesion [GO:0098609]; cellular response to cytokine stimulus [GO:0071345]; cellular response to organic cyclic compound [GO:0071407]; detection of wounding [GO:0014822]; determination of left/right symmetry [GO:0007368]; digestive tract development [GO:0048565]; ductus arteriosus closure [GO:0097070]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic ectodermal digestive tract morphogenesis [GO:0048613]; embryonic foregut morphogenesis [GO:0048617]; endocardial cushion development [GO:0003197]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of epithelial cell apical/basal polarity [GO:0045198]; extracellular matrix organization [GO:0030198]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lateral mesodermal cell differentiation [GO:0048371]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung lobe morphogenesis [GO:0060463]; lung vasculature development [GO:0060426]; mesenchyme migration [GO:0090131]; midgut development [GO:0007494]; morphogenesis of a branching structure [GO:0001763]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pancreas development [GO:0031016]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory tube development [GO:0030323]; right lung morphogenesis [GO:0060461]; smooth muscle cell differentiation [GO:0051145]; smoothened signaling pathway [GO:0007224]; somitogenesis [GO:0001756]; trachea development [GO:0060438]; ureter development [GO:0072189]; vasculogenesis [GO:0001570]; venous blood vessel development [GO:0060841]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; animal organ morphogenesis [GO:0009887]; blood vessel development [GO:0001568]; cardiac left ventricle morphogenesis [GO:0003214]; cell-cell adhesion [GO:0098609]; cellular response to cytokine stimulus [GO:0071345]; cellular response to organic cyclic compound [GO:0071407]; detection of wounding [GO:0014822]; determination of left/right symmetry [GO:0007368]; digestive tract development [GO:0048565]; ductus arteriosus closure [GO:0097070]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic ectodermal digestive tract morphogenesis [GO:0048613]; embryonic foregut morphogenesis [GO:0048617]; endocardial cushion development [GO:0003197]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of epithelial cell apical/basal polarity [GO:0045198]; extracellular matrix organization [GO:0030198]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lateral mesodermal cell differentiation [GO:0048371]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung lobe morphogenesis [GO:0060463]; lung vasculature development [GO:0060426]; mesenchyme migration [GO:0090131]; midgut development [GO:0007494]; morphogenesis of a branching structure [GO:0001763]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pancreas development [GO:0031016]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory tube development [GO:0030323]; right lung morphogenesis [GO:0060461]; smooth muscle cell differentiation [GO:0051145]; smoothened signaling pathway [GO:0007224]; somitogenesis [GO:0001756]; trachea development [GO:0060438]; ureter development [GO:0072189]; vasculogenesis [GO:0001570]; venous blood vessel development [GO:0060841]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q12947	reviewed	FOXF2_HUMAN	Forkhead box protein F2 (Forkhead-related activator 2) (FREAC-2) (Forkhead-related protein FKHL6) (Forkhead-related transcription factor 2)	FOXF2 FKHL6 FREAC2	Homo sapiens (Human)	444	FUNCTION: Probable transcription activator for a number of lung-specific genes (PubMed:8626802). Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (PubMed:29374064). {ECO:0000269|PubMed:29374064, ECO:0000269|PubMed:8626802}.		animal organ morphogenesis [GO:0009887]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digestive tract development [GO:0048566]; epithelial to mesenchymal transition [GO:0001837]; establishment of planar polarity of embryonic epithelium [GO:0042249]; extracellular matrix organization [GO:0030198]; genitalia development [GO:0048806]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein polyubiquitination [GO:1902914]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; general transcription initiation factor binding [GO:0140296]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; TFIIB-class transcription factor binding [GO:0001093]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; general transcription initiation factor binding [GO:0140296]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; TFIIB-class transcription factor binding [GO:0001093]; animal organ morphogenesis [GO:0009887]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digestive tract development [GO:0048566]; epithelial to mesenchymal transition [GO:0001837]; establishment of planar polarity of embryonic epithelium [GO:0042249]; extracellular matrix organization [GO:0030198]; genitalia development [GO:0048806]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein polyubiquitination [GO:1902914]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29374064, ECO:0000269|PubMed:9799607}.
Q12948	reviewed	FOXC1_HUMAN	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3)	FOXC1 FKHL7 FREAC3	Homo sapiens (Human)	553	FUNCTION: DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:15299087, PubMed:15684392, PubMed:16492674, PubMed:27907090, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:16449236, PubMed:17210863, PubMed:19793056, PubMed:19279310, PubMed:25786029, PubMed:27804176). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:7957066, PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176). Upon DNA-binding, promotes DNA bending (PubMed:7957066, PubMed:14506133). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}.		anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; apoptotic process involved in outflow tract morphogenesis [GO:0003275]; artery morphogenesis [GO:0048844]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; camera-type eye development [GO:0043010]; cardiac muscle cell proliferation [GO:0060038]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cellular response to chemokine [GO:1990869]; cellular response to epidermal growth factor stimulus [GO:0071364]; cerebellum development [GO:0021549]; chemokine-mediated signaling pathway [GO:0070098]; collagen fibril organization [GO:0030199]; embryonic heart tube development [GO:0035050]; endochondral ossification [GO:0001958]; eye development [GO:0001654]; germ cell migration [GO:0008354]; glomerular epithelium development [GO:0072010]; glycosaminoglycan metabolic process [GO:0030203]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lacrimal gland development [GO:0032808]; lymph vessel development [GO:0001945]; maintenance of lens transparency [GO:0036438]; mesenchymal cell development [GO:0014031]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process involved in outflow tract morphogenesis [GO:1902257]; negative regulation of lymphangiogenesis [GO:1901491]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; paraxial mesoderm formation [GO:0048341]; positive regulation of core promoter binding [GO:1904798]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of hematopoietic stem cell differentiation [GO:1902038]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of organ growth [GO:0046620]; regulation of transcription by RNA polymerase II [GO:0006357]; somitogenesis [GO:0001756]; ureteric bud development [GO:0001657]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	chromatin [GO:0000785]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; apoptotic process involved in outflow tract morphogenesis [GO:0003275]; artery morphogenesis [GO:0048844]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; camera-type eye development [GO:0043010]; cardiac muscle cell proliferation [GO:0060038]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cellular response to chemokine [GO:1990869]; cellular response to epidermal growth factor stimulus [GO:0071364]; cerebellum development [GO:0021549]; chemokine-mediated signaling pathway [GO:0070098]; collagen fibril organization [GO:0030199]; embryonic heart tube development [GO:0035050]; endochondral ossification [GO:0001958]; eye development [GO:0001654]; germ cell migration [GO:0008354]; glomerular epithelium development [GO:0072010]; glycosaminoglycan metabolic process [GO:0030203]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lacrimal gland development [GO:0032808]; lymph vessel development [GO:0001945]; maintenance of lens transparency [GO:0036438]; mesenchymal cell development [GO:0014031]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process involved in outflow tract morphogenesis [GO:1902257]; negative regulation of lymphangiogenesis [GO:1901491]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; paraxial mesoderm formation [GO:0048341]; positive regulation of core promoter binding [GO:1904798]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of hematopoietic stem cell differentiation [GO:1902038]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of organ growth [GO:0046620]; regulation of transcription by RNA polymerase II [GO:0006357]; somitogenesis [GO:0001756]; ureteric bud development [GO:0001657]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176}. Note=Colocalizes with PITX2 isoform 3 in the nucleus at subnuclear chromatine regions (PubMed:16449236). Colocalizes with CBX5 to a heterochromatin-rich region of the nucleus (PubMed:15684392). Colocalizes with GLI2 in the nucleus (By similarity). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236}.
Q12951	reviewed	FOXI1_HUMAN	Forkhead box protein I1 (Forkhead-related protein FKHL10) (Forkhead-related transcription factor 6) (FREAC-6) (Hepatocyte nuclear factor 3 forkhead homolog 3) (HFH-3) (HNF-3/fork-head homolog 3)	FOXI1 FKHL10 FREAC6	Homo sapiens (Human)	378	FUNCTION: Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity). {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; embryo development ending in birth or egg hatching [GO:0009792]; inner ear morphogenesis [GO:0042472]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]	DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; embryo development ending in birth or egg hatching [GO:0009792]; inner ear morphogenesis [GO:0042472]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q12952	reviewed	FOXL1_HUMAN	Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7)	FOXL1 FKHL11 FREAC7	Homo sapiens (Human)	345	FUNCTION: Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 and GLI3 transcription factors (By similarity). {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; heart development [GO:0007507]; Peyer's patch morphogenesis [GO:0061146]; proteoglycan biosynthetic process [GO:0030166]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]; visceral mesoderm-endoderm interaction involved in midgut development [GO:0007495]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; heart development [GO:0007507]; Peyer's patch morphogenesis [GO:0061146]; proteoglycan biosynthetic process [GO:0030166]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]; visceral mesoderm-endoderm interaction involved in midgut development [GO:0007495]	SUBCELLULAR LOCATION: Nucleus.
Q12955	reviewed	ANK3_HUMAN	Ankyrin-3 (ANK-3) (Ankyrin-G)	ANK3	Homo sapiens (Human)	4377	FUNCTION: In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). {ECO:0000250, ECO:0000269|PubMed:17974005}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}.	MISCELLANEOUS: [Isoform 5]: Avidly binds beta spectrin. {ECO:0000305}.	axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to axon [GO:0099612]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]	axon initial segment [GO:0043194]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; costamere [GO:0043034]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; lysosome [GO:0005764]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; spectrin-associated cytoskeleton [GO:0014731]; T-tubule [GO:0030315]; Z disc [GO:0030018]	cadherin binding [GO:0045296]; cytoskeletal anchor activity [GO:0008093]; cytoskeletal protein binding [GO:0008092]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325]	axon initial segment [GO:0043194]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; costamere [GO:0043034]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; lysosome [GO:0005764]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; spectrin-associated cytoskeleton [GO:0014731]; T-tubule [GO:0030315]; Z disc [GO:0030018]; cadherin binding [GO:0045296]; cytoskeletal anchor activity [GO:0008093]; cytoskeletal protein binding [GO:0008092]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to axon [GO:0099612]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21223964}. Cell projection, axon {ECO:0000250|UniProtKB:O70511}. Cell membrane, sarcolemma {ECO:0000269|PubMed:21223964}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:O70511}. Lysosome {ECO:0000250|UniProtKB:G5E8K5}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O70511}. Note=In skeletal muscle, localized at costameres and neuromuscular junctions. In macrophages, associated with lysosomes. {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8666667}. Golgi apparatus {ECO:0000269|PubMed:8666667}.
Q12959	reviewed	DLG1_HUMAN	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)	DLG1	Homo sapiens (Human)	904	FUNCTION: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}.		actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; amyloid precursor protein metabolic process [GO:0042982]; astral microtubule organization [GO:0030953]; bicellular tight junction assembly [GO:0070830]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; cortical actin cytoskeleton organization [GO:0030866]; cortical microtubule organization [GO:0043622]; embryonic skeletal system morphogenesis [GO:0048704]; endothelial cell proliferation [GO:0001935]; establishment of centrosome localization [GO:0051660]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; hard palate development [GO:0060022]; immunological synapse formation [GO:0001771]; lens development in camera-type eye [GO:0002088]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; peristalsis [GO:0030432]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; protein-containing complex localization [GO:0031503]; receptor clustering [GO:0043113]; regulation of cell shape [GO:0008360]; regulation of membrane potential [GO:0042391]; regulation of myelination [GO:0031641]; regulation of potassium ion export across plasma membrane [GO:1903764]; regulation of potassium ion import [GO:1903286]; regulation of protein localization to synapse [GO:1902473]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903760]; reproductive structure development [GO:0048608]; smooth muscle tissue development [GO:0048745]; T cell proliferation [GO:0042098]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; intercalated disc [GO:0014704]; lateral loop [GO:0043219]; lateral plasma membrane [GO:0016328]; membrane raft [GO:0045121]; microtubule [GO:0005874]; MPP7-DLG1-LIN7 complex [GO:0097025]; myelin sheath abaxonal region [GO:0035748]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; node of Ranvier [GO:0033268]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; sarcolemma [GO:0042383]; synaptic membrane [GO:0097060]	cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; guanylate kinase activity [GO:0004385]; kinase binding [GO:0019900]; L27 domain binding [GO:0097016]; molecular adaptor activity [GO:0060090]; phosphatase binding [GO:0019902]; phosphoprotein phosphatase activity [GO:0004721]; potassium channel regulator activity [GO:0015459]; structural constituent of postsynaptic density [GO:0098919]; transmembrane transporter binding [GO:0044325]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; intercalated disc [GO:0014704]; lateral loop [GO:0043219]; lateral plasma membrane [GO:0016328]; membrane raft [GO:0045121]; microtubule [GO:0005874]; MPP7-DLG1-LIN7 complex [GO:0097025]; myelin sheath abaxonal region [GO:0035748]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; node of Ranvier [GO:0033268]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; sarcolemma [GO:0042383]; synaptic membrane [GO:0097060]; cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; guanylate kinase activity [GO:0004385]; kinase binding [GO:0019900]; L27 domain binding [GO:0097016]; molecular adaptor activity [GO:0060090]; phosphatase binding [GO:0019902]; phosphoprotein phosphatase activity [GO:0004721]; potassium channel regulator activity [GO:0015459]; structural constituent of postsynaptic density [GO:0098919]; transmembrane transporter binding [GO:0044325]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; amyloid precursor protein metabolic process [GO:0042982]; astral microtubule organization [GO:0030953]; bicellular tight junction assembly [GO:0070830]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; cortical actin cytoskeleton organization [GO:0030866]; cortical microtubule organization [GO:0043622]; embryonic skeletal system morphogenesis [GO:0048704]; endothelial cell proliferation [GO:0001935]; establishment of centrosome localization [GO:0051660]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; hard palate development [GO:0060022]; immunological synapse formation [GO:0001771]; lens development in camera-type eye [GO:0002088]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; peristalsis [GO:0030432]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; protein-containing complex localization [GO:0031503]; receptor clustering [GO:0043113]; regulation of cell shape [GO:0008360]; regulation of membrane potential [GO:0042391]; regulation of myelination [GO:0031641]; regulation of potassium ion export across plasma membrane [GO:1903764]; regulation of potassium ion import [GO:1903286]; regulation of protein localization to synapse [GO:1902473]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903760]; reproductive structure development [GO:0048608]; smooth muscle tissue development [GO:0048745]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:11723125, ECO:0000269|PubMed:8922391}; Peripheral membrane protein {ECO:0000269|PubMed:8922391}. Basolateral cell membrane {ECO:0000269|PubMed:12807908}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q62696}. Postsynaptic density {ECO:0000250|UniProtKB:Q62696}. Synapse {ECO:0000250|UniProtKB:Q62696}. Cell membrane, sarcolemma {ECO:0000269|PubMed:12445884}. Apical cell membrane {ECO:0000269|PubMed:12445884}. Cell junction {ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:11723125, ECO:0000269|PubMed:7937897}. Cytoplasm {ECO:0000269|PubMed:10859302}. Note=Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells (PubMed:12807908). May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity). {ECO:0000250|UniProtKB:Q62696, ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:12807908, ECO:0000269|PubMed:8922391, ECO:0000269|PubMed:9192623}.
Q12962	reviewed	TAF10_HUMAN	Transcription initiation factor TFIID subunit 10 (STAF28) (Transcription initiation factor TFIID 30 kDa subunit) (TAF(II)30) (TAFII-30) (TAFII30)	TAF10 TAF2A TAF2H TAFII30	Homo sapiens (Human)	218	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex (PubMed:18206972, PubMed:11564863, PubMed:9885574, PubMed:10373431, PubMed:12601814). May regulate cyclin E expression (By similarity). {ECO:0000250|UniProtKB:Q8K0H5, ECO:0000269|PubMed:10373431, ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:12601814, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:9885574}.		allantois development [GO:1905069]; apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; DNA-templated transcription initiation [GO:0006352]; embryonic placenta development [GO:0001892]; G1/S transition of mitotic cell cycle [GO:0000082]; hepatocyte differentiation [GO:0070365]; lateral mesodermal cell differentiation [GO:0048371]; limb development [GO:0060173]; mRNA transcription by RNA polymerase II [GO:0042789]; multicellular organism growth [GO:0035264]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; SAGA complex assembly [GO:0036285]; somitogenesis [GO:0001756]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; transcription preinitiation complex [GO:0097550]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase binding [GO:0070063]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; transcription preinitiation complex [GO:0097550]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase binding [GO:0070063]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; allantois development [GO:1905069]; apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; DNA-templated transcription initiation [GO:0006352]; embryonic placenta development [GO:0001892]; G1/S transition of mitotic cell cycle [GO:0000082]; hepatocyte differentiation [GO:0070365]; lateral mesodermal cell differentiation [GO:0048371]; limb development [GO:0060173]; mRNA transcription by RNA polymerase II [GO:0042789]; multicellular organism growth [GO:0035264]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; SAGA complex assembly [GO:0036285]; somitogenesis [GO:0001756]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:25959397, ECO:0000269|PubMed:9674425}.
Q12965	reviewed	MYO1E_HUMAN	Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E)	MYO1E MYO1C	Homo sapiens (Human)	1108	FUNCTION: Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408, ECO:0000269|PubMed:36316095}.		actin filament organization [GO:0007015]; endocytosis [GO:0006897]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; in utero embryonic development [GO:0001701]; nitrogen compound metabolic process [GO:0006807]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; podocyte development [GO:0072015]; post-embryonic hemopoiesis [GO:0035166]; vasculogenesis [GO:0001570]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; brush border [GO:0005903]; clathrin-coated vesicle [GO:0030136]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol binding [GO:0035091]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; brush border [GO:0005903]; clathrin-coated vesicle [GO:0030136]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol binding [GO:0035091]; actin filament organization [GO:0007015]; endocytosis [GO:0006897]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; in utero embryonic development [GO:0001701]; nitrogen compound metabolic process [GO:0006807]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; podocyte development [GO:0072015]; post-embryonic hemopoiesis [GO:0035166]; vasculogenesis [GO:0001570]; vesicle transport along actin filament [GO:0030050]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:E9Q634}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:E9Q634}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:E9Q634}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:36316095}. Cell junction {ECO:0000269|PubMed:36316095}. Note=Colocalizes with F-actin (By similarity). In cultured podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips. Colocalizes with cytoplasmic vesicles, including endocytic clathrin-coated vesicles. Colocalizes with dynamin at cytoplasmic vesicles. {ECO:0000250}.
Q12967	reviewed	GNDS_HUMAN	Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF)	RALGDS KIAA1308 RGF	Homo sapiens (Human)	914	FUNCTION: Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap (By similarity). During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex (PubMed:27438768). {ECO:0000250|UniProtKB:Q03385, ECO:0000269|PubMed:27438768}.		Ras protein signal transduction [GO:0007265]	brush border [GO:0005903]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GTPase regulator activity [GO:0030695]; guanyl-nucleotide exchange factor activity [GO:0005085]	brush border [GO:0005903]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; GTPase regulator activity [GO:0030695]; guanyl-nucleotide exchange factor activity [GO:0005085]; Ras protein signal transduction [GO:0007265]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q03385}. Nucleus {ECO:0000250|UniProtKB:Q03385}. Note=Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus. {ECO:0000250|UniProtKB:Q03385}.
Q12968	reviewed	NFAC3_HUMAN	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c)	NFATC3 NFAT4	Homo sapiens (Human)	1075	FUNCTION: Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Along with NFATC4, involved in embryonic heart development (By similarity). {ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128}.		calcineurin-NFAT signaling cascade [GO:0033173]; inflammatory response [GO:0006954]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; calcineurin-NFAT signaling cascade [GO:0033173]; inflammatory response [GO:0006954]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18815128}. Nucleus {ECO:0000269|PubMed:18815128}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Q12972	reviewed	PP1R8_HUMAN	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)]	PPP1R8 ARD1 NIPP1	Homo sapiens (Human)	351	FUNCTION: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.; FUNCTION: Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.	MISCELLANEOUS: A synthetic peptide, NIPP-1(330-351), is able to inhibit PP-1. Phosphorylation of Tyr-335 reduces PP-1 inhibition, whereas phosphorylation of Thr-346 or Ser-348 has no effect.	cell population proliferation [GO:0008283]; mRNA processing [GO:0006397]; negative regulation of protein dephosphorylation [GO:0035308]; RNA catabolic process [GO:0006401]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; molecular function inhibitor activity [GO:0140678]; mRNA binding [GO:0003729]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ribonuclease E activity [GO:0008995]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; molecular function inhibitor activity [GO:0140678]; mRNA binding [GO:0003729]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ribonuclease E activity [GO:0008995]; RNA binding [GO:0003723]; cell population proliferation [GO:0008283]; mRNA processing [GO:0006397]; negative regulation of protein dephosphorylation [GO:0035308]; RNA catabolic process [GO:0006401]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear.; SUBCELLULAR LOCATION: [Isoform Gamma]: Cytoplasm. Note=Found mainly in the cytoplasm.
Q12974	reviewed	TP4A2_HUMAN	Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2)	PTP4A2 PRL2 PTPCAAX2 BM-008	Homo sapiens (Human)	167	FUNCTION: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. {ECO:0000269|PubMed:14643450}.	MISCELLANEOUS: A processed pseudogene with 96% sequence identity was found in the BRCA1 (113705) region of 17q21.	dephosphorylation [GO:0016311]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	prenylated protein tyrosine phosphatase activity [GO:0004727]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; prenylated protein tyrosine phosphatase activity [GO:0004727]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; dephosphorylation [GO:0016311]	SUBCELLULAR LOCATION: Cell membrane. Early endosome. Cytoplasm.
Q12979	reviewed	ABR_HUMAN	Active breakpoint cluster region-related protein	ABR	Homo sapiens (Human)	859	FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q5SSL4, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:7479768}.		activation of GTPase activity [GO:0090630]; modulation of chemical synaptic transmission [GO:0050804]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	axon [GO:0030424]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; Schaffer collateral - CA1 synapse [GO:0098685]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	axon [GO:0030424]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; Schaffer collateral - CA1 synapse [GO:0098685]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; activation of GTPase activity [GO:0090630]; modulation of chemical synaptic transmission [GO:0050804]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q5SSL4}. Cell projection, axon {ECO:0000250|UniProtKB:Q5SSL4}. Synapse {ECO:0000250|UniProtKB:A0A0G2JTR4}.
Q12980	reviewed	NPRL3_HUMAN	GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA)	NPRL3 C16orf35 CGTHBA MARE	Homo sapiens (Human)	569	FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:29590090, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:29590090, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:35338845}.		aorta morphogenesis [GO:0035909]; cardiac muscle tissue development [GO:0048738]; cellular response to amino acid starvation [GO:0034198]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]; roof of mouth development [GO:0060021]; TORC1 signaling [GO:0038202]; ventricular septum development [GO:0003281]	GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765]	GTPase activator activity [GO:0005096]	GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765]; GTPase activator activity [GO:0005096]; aorta morphogenesis [GO:0035909]; cardiac muscle tissue development [GO:0048738]; cellular response to amino acid starvation [GO:0034198]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]; roof of mouth development [GO:0060021]; TORC1 signaling [GO:0038202]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28199306}. Note=Localization to lysosomes is mediated by the KICSTOR complex and is amino acid-independent. {ECO:0000269|PubMed:28199306}.
Q12981	reviewed	SEC20_HUMAN	Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8)	BNIP1 NIP1 SEC20L TRG8	Homo sapiens (Human)	228	FUNCTION: As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311). Also plays a role in apoptosis (PubMed:7954800, PubMed:15272311, PubMed:23896122). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable). {ECO:0000269|PubMed:15272311, ECO:0000269|PubMed:23896122, ECO:0000269|PubMed:7954800, ECO:0000305|PubMed:21931693}.		apoptotic process [GO:0006915]; apoptotic process in response to mitochondrial fragmentation [GO:0140208]; endoplasmic reticulum membrane fusion [GO:0016320]; endoplasmic reticulum organization [GO:0007029]; execution phase of apoptosis [GO:0097194]; negative regulation of apoptotic process [GO:0043066]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; SNARE complex [GO:0031201]	calcium-induced calcium release activity [GO:0048763]; SNAP receptor activity [GO:0005484]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; SNARE complex [GO:0031201]; calcium-induced calcium release activity [GO:0048763]; SNAP receptor activity [GO:0005484]; apoptotic process [GO:0006915]; apoptotic process in response to mitochondrial fragmentation [GO:0140208]; endoplasmic reticulum membrane fusion [GO:0016320]; endoplasmic reticulum organization [GO:0007029]; execution phase of apoptosis [GO:0097194]; negative regulation of apoptotic process [GO:0043066]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15272311, ECO:0000269|PubMed:23896122}; Single-pass type IV membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:21931693, ECO:0000269|PubMed:23896122}; Single-pass type IV membrane protein {ECO:0000255}. Note=Localization to the mitochondrion is regulated by RNF186. {ECO:0000269|PubMed:23896122}.
Q12982	reviewed	BNIP2_HUMAN	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2	BNIP2 NIP2	Homo sapiens (Human)	314	FUNCTION: Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; response to oxygen-glucose deprivation [GO:0090649]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]	calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; response to oxygen-glucose deprivation [GO:0090649]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to other cytoplasmic structures.
Q12983	reviewed	BNIP3_HUMAN	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3	BNIP3 NIP3	Homo sapiens (Human)	194	FUNCTION: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}.		autophagic cell death [GO:0048102]; autophagy of mitochondrion [GO:0000422]; brown fat cell differentiation [GO:0050873]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to cobalt ion [GO:0071279]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to mechanical stimulus [GO:0071260]; cerebral cortex development [GO:0021987]; defense response to virus [GO:0051607]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrial protein catabolic process [GO:0035694]; negative regulation of apoptotic process [GO:0043066]; negative regulation of membrane potential [GO:0045837]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neuron apoptotic process [GO:0051402]; oligodendrocyte differentiation [GO:0048709]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; reactive oxygen species metabolic process [GO:0072593]; regulation of aerobic respiration [GO:1903715]; regulation of mitochondrial membrane permeability [GO:0046902]; response to axon injury [GO:0048678]; response to bacterium [GO:0009617]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to oxygen-glucose deprivation [GO:0090649]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; autophagic cell death [GO:0048102]; autophagy of mitochondrion [GO:0000422]; brown fat cell differentiation [GO:0050873]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to cobalt ion [GO:0071279]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to mechanical stimulus [GO:0071260]; cerebral cortex development [GO:0021987]; defense response to virus [GO:0051607]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrial protein catabolic process [GO:0035694]; negative regulation of apoptotic process [GO:0043066]; negative regulation of membrane potential [GO:0045837]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neuron apoptotic process [GO:0051402]; oligodendrocyte differentiation [GO:0048709]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; reactive oxygen species metabolic process [GO:0072593]; regulation of aerobic respiration [GO:1903715]; regulation of mitochondrial membrane permeability [GO:0046902]; response to axon injury [GO:0048678]; response to bacterium [GO:0009617]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to oxygen-glucose deprivation [GO:0090649]	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.
Q12986	reviewed	NFX1_HUMAN	Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1)	NFX1 NFX2	Homo sapiens (Human)	1120	FUNCTION: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}.		inflammatory response [GO:0006954]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; inflammatory response [GO:0006954]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
Q12996	reviewed	CSTF3_HUMAN	Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77)	CSTF3	Homo sapiens (Human)	717	FUNCTION: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.		co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; RNA 3'-end processing [GO:0031123]	mRNA cleavage stimulating factor complex [GO:0005848]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	mRNA cleavage stimulating factor complex [GO:0005848]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; RNA 3'-end processing [GO:0031123]	SUBCELLULAR LOCATION: Nucleus.
Q13002	reviewed	GRIK2_HUMAN	Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)	GRIK2 GLUR6	Homo sapiens (Human)	908	FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184). Modulates cell surface expression of NETO2 (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:28180184}.; FUNCTION: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:31474366}.	MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > quisqualate > 6-cyano-7-nitroquinoxaline-2,3-dione > L-glutamate = 6,7-dinitroquinoxaline-2,3-dione > dihydrokainate.; MISCELLANEOUS: [Isoform 6]: Seems to be specific for non-neuronal cells. May not function as active channel. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Seems to be specific for non-neuronal cells. May not function as active channel. {ECO:0000305}.	behavioral fear response [GO:0001662]; chemical synaptic transmission [GO:0007268]; detection of cold stimulus involved in thermoception [GO:0120169]; glutamate receptor signaling pathway [GO:0007215]; inhibitory postsynaptic potential [GO:0060080]; intracellular calcium ion homeostasis [GO:0006874]; modulation of chemical synaptic transmission [GO:0050804]; modulation of excitatory postsynaptic potential [GO:0098815]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuron apoptotic process [GO:0051402]; neuronal action potential [GO:0019228]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of synaptic transmission [GO:0050806]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; receptor clustering [GO:0043113]; regulation of JNK cascade [GO:0046328]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]	dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; mossy fiber rosette [GO:0097471]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; terminal bouton [GO:0043195]	extracellularly glutamate-gated ion channel activity [GO:0005234]; identical protein binding [GO:0042802]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; PDZ domain binding [GO:0030165]; scaffold protein binding [GO:0097110]; SNARE binding [GO:0000149]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625]	dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; mossy fiber rosette [GO:0097471]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; terminal bouton [GO:0043195]; extracellularly glutamate-gated ion channel activity [GO:0005234]; identical protein binding [GO:0042802]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; PDZ domain binding [GO:0030165]; scaffold protein binding [GO:0097110]; SNARE binding [GO:0000149]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625]; behavioral fear response [GO:0001662]; chemical synaptic transmission [GO:0007268]; detection of cold stimulus involved in thermoception [GO:0120169]; glutamate receptor signaling pathway [GO:0007215]; inhibitory postsynaptic potential [GO:0060080]; intracellular calcium ion homeostasis [GO:0006874]; modulation of chemical synaptic transmission [GO:0050804]; modulation of excitatory postsynaptic potential [GO:0098815]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuron apoptotic process [GO:0051402]; neuronal action potential [GO:0019228]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of synaptic transmission [GO:0050806]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; receptor clustering [GO:0043113]; regulation of JNK cascade [GO:0046328]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:34375587}; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Q13003	reviewed	GRIK3_HUMAN	Glutamate receptor ionotropic, kainate 3 (GluK3) (Excitatory amino acid receptor 5) (EAA5) (Glutamate receptor 7) (GluR-7) (GluR7)	GRIK3 GLUR7	Homo sapiens (Human)	919	FUNCTION: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.		G protein-coupled glutamate receptor signaling pathway [GO:0007216]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; regulation of membrane potential [GO:0042391]; synaptic transmission, glutamatergic [GO:0035249]	axon [GO:0030424]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; kainate selective glutamate receptor complex [GO:0032983]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; terminal bouton [GO:0043195]	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; glutamate receptor activity [GO:0008066]; ionotropic glutamate receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	axon [GO:0030424]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; kainate selective glutamate receptor complex [GO:0032983]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; terminal bouton [GO:0043195]; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; glutamate receptor activity [GO:0008066]; ionotropic glutamate receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; regulation of membrane potential [GO:0042391]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Q13007	reviewed	IL24_HUMAN	Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein)	IL24 MDA7 ST16	Homo sapiens (Human)	206	FUNCTION: Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I intereferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity). {ECO:0000250|UniProtKB:Q925S4, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:25168428, ECO:0000269|PubMed:27687232, ECO:0000269|PubMed:30111632}.		apoptotic process [GO:0006915]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; apoptotic process [GO:0006915]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11706020}.
Q13009	reviewed	TIAM1_HUMAN	Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)	TIAM1	Homo sapiens (Human)	1591	FUNCTION: Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}.		activation of GTPase activity [GO:0090630]; cardiac muscle hypertrophy [GO:0003300]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; ephrin receptor signaling pathway [GO:0048013]; neuron projection extension [GO:1990138]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of protein binding [GO:0032092]; positive regulation of Schwann cell chemotaxis [GO:1904268]; protein localization to membrane [GO:0072657]; protein-containing complex assembly [GO:0065003]; Rac protein signal transduction [GO:0016601]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of non-canonical Wnt signaling pathway [GO:2000050]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to cocaine [GO:0042220]; small GTPase mediated signal transduction [GO:0007264]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	axonal growth cone [GO:0044295]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; main axon [GO:0044304]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; synapse [GO:0045202]	guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; receptor tyrosine kinase binding [GO:0030971]	axonal growth cone [GO:0044295]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; main axon [GO:0044304]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; synapse [GO:0045202]; guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; receptor tyrosine kinase binding [GO:0030971]; activation of GTPase activity [GO:0090630]; cardiac muscle hypertrophy [GO:0003300]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; ephrin receptor signaling pathway [GO:0048013]; neuron projection extension [GO:1990138]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of protein binding [GO:0032092]; positive regulation of Schwann cell chemotaxis [GO:1904268]; protein localization to membrane [GO:0072657]; protein-containing complex assembly [GO:0065003]; Rac protein signal transduction [GO:0016601]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of non-canonical Wnt signaling pathway [GO:2000050]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to cocaine [GO:0042220]; small GTPase mediated signal transduction [GO:0007264]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.
Q13011	reviewed	ECH1_HUMAN	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-)	ECH1	Homo sapiens (Human)	328	FUNCTION: Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. {ECO:0000250|UniProtKB:Q62651}.		fatty acid beta-oxidation [GO:0006635]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity [GO:0051750]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity [GO:0051750]; fatty acid beta-oxidation [GO:0006635]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q62651}. Peroxisome {ECO:0000250|UniProtKB:Q62651}.
Q13015	reviewed	AF1Q_HUMAN	Protein AF1q	MLLT11 AF1Q	Homo sapiens (Human)	90	FUNCTION: Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312). {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}.		extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}. Cytoplasm {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21715312}. Note=Continuous nuclear export is followed by degradation. {ECO:0000269|PubMed:21715312}.
Q13017	reviewed	RHG05_HUMAN	Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B)	ARHGAP5 RHOGAP5	Homo sapiens (Human)	1502	FUNCTION: GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}.		cell adhesion [GO:0007155]; epithelial cell migration [GO:0010631]; mammary gland development [GO:0030879]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of mesenchymal cell proliferation [GO:0002053]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; SH2 domain binding [GO:0042169]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; SH2 domain binding [GO:0042169]; cell adhesion [GO:0007155]; epithelial cell migration [GO:0010631]; mammary gland development [GO:0030879]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of mesenchymal cell proliferation [GO:0002053]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8537347}. Cell membrane {ECO:0000269|PubMed:8537347}; Peripheral membrane protein {ECO:0000269|PubMed:8537347}. Note=Also membrane-associated in a fibrillar pattern that colocalizes with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin. {ECO:0000269|PubMed:8537347}.
Q13018	reviewed	PLA2R_HUMAN	Secretory phospholipase A2 receptor (PLA2-R) (PLA2R) (180 kDa secretory phospholipase A2 receptor) (C-type lectin domain family 13 member C) (M-type receptor) [Cleaved into: Soluble secretory phospholipase A2 receptor (Soluble PLA2-R) (Soluble PLA2R)]	PLA2R1 CLEC13C	Homo sapiens (Human)	1463	FUNCTION: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B (PubMed:15611272, PubMed:7721806). In podocytes, binding of sPLA2-IB/PLA2G1B can regulate podocyte survival and glomerular homeostasis (PubMed:25335547). {ECO:0000269|PubMed:15611272, ECO:0000269|PubMed:25335547, ECO:0000269|PubMed:7721806}.		negative regulation of arachidonic acid secretion [GO:1900139]; negative regulation of phospholipase A2 activity [GO:1900138]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of podocyte apoptotic process [GO:1904635]; reactive oxygen species metabolic process [GO:0072593]; receptor-mediated endocytosis [GO:0006898]; replicative senescence [GO:0090399]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	carbohydrate binding [GO:0030246]; phospholipase binding [GO:0043274]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; carbohydrate binding [GO:0030246]; phospholipase binding [GO:0043274]; signaling receptor activity [GO:0038023]; negative regulation of arachidonic acid secretion [GO:1900139]; negative regulation of phospholipase A2 activity [GO:1900138]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of podocyte apoptotic process [GO:1904635]; reactive oxygen species metabolic process [GO:0072593]; receptor-mediated endocytosis [GO:0006898]; replicative senescence [GO:0090399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Soluble secretory phospholipase A2 receptor]: Secreted {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q13021	reviewed	MALL_HUMAN	MAL-like protein (Protein BENE)	MALL BENE	Homo sapiens (Human)	153			cholesterol homeostasis [GO:0042632]; myelination [GO:0042552]	clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle [GO:0031410]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	structural constituent of myelin sheath [GO:0019911]	clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle [GO:0031410]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; structural constituent of myelin sheath [GO:0019911]; cholesterol homeostasis [GO:0042632]; myelination [GO:0042552]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q13023	reviewed	AKAP6_HUMAN	A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP)	AKAP6 AKAP100 KIAA0311	Homo sapiens (Human)	2319	FUNCTION: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.		action potential [GO:0001508]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cytokine stimulus [GO:0071345]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cell growth [GO:0030307]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; protein targeting [GO:0006605]; regulation of membrane repolarization [GO:0060306]; regulation of protein kinase A signaling [GO:0010738]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	calcium channel complex [GO:0034704]; caveola [GO:0005901]; cytoplasm [GO:0005737]; intercalated disc [GO:0014704]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum [GO:0016529]; T-tubule [GO:0030315]	adenylate cyclase binding [GO:0008179]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein-membrane adaptor activity [GO:0043495]; transmembrane transporter binding [GO:0044325]	calcium channel complex [GO:0034704]; caveola [GO:0005901]; cytoplasm [GO:0005737]; intercalated disc [GO:0014704]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum [GO:0016529]; T-tubule [GO:0030315]; adenylate cyclase binding [GO:0008179]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein-membrane adaptor activity [GO:0043495]; transmembrane transporter binding [GO:0044325]; action potential [GO:0001508]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cytokine stimulus [GO:0071345]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cell growth [GO:0030307]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; protein targeting [GO:0006605]; regulation of membrane repolarization [GO:0060306]; regulation of protein kinase A signaling [GO:0010738]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum. Nucleus membrane. Note=In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences.
Q13029	reviewed	PRDM2_HUMAN	PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ)	PRDM2 KMT8 RIZ	Homo sapiens (Human)	1718	FUNCTION: S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}.	MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation at Met-202 of isoform 1. {ECO:0000305}.	determination of adult lifespan [GO:0008340]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone H3K9 trimethyltransferase activity [GO:0140949]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone H3K9 trimethyltransferase activity [GO:0140949]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]; determination of adult lifespan [GO:0008340]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14633678, ECO:0000269|PubMed:7538672, ECO:0000269|PubMed:9006946}.
Q13033	reviewed	STRN3_HUMAN	Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)	STRN3 GS2NA SG2NA	Homo sapiens (Human)	797	FUNCTION: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to estradiol [GO:0032355]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to estradiol [GO:0032355]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q13042	reviewed	CDC16_HUMAN	Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6)	CDC16 ANAPC6	Homo sapiens (Human)	620	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]		anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:7736578}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:7736578}. Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
Q13043	reviewed	STK4_HUMAN	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]	STK4 KRS2 MST1	Homo sapiens (Human)	487	FUNCTION: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}.		apoptotic process [GO:0006915]; branching involved in blood vessel morphogenesis [GO:0001569]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation involved in embryonic placenta development [GO:0060706]; cell morphogenesis [GO:0000902]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; keratinocyte differentiation [GO:0030216]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; organ growth [GO:0035265]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte apoptotic process [GO:1903945]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; primitive hemopoiesis [GO:0060215]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; apoptotic process [GO:0006915]; branching involved in blood vessel morphogenesis [GO:0001569]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation involved in embryonic placenta development [GO:0060706]; cell morphogenesis [GO:0000902]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; keratinocyte differentiation [GO:0030216]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; organ growth [GO:0035265]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte apoptotic process [GO:1903945]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; primitive hemopoiesis [GO:0060215]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Q13045	reviewed	FLII_HUMAN	Protein flightless-1 homolog	FLII FLIL	Homo sapiens (Human)	1269	FUNCTION: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. {ECO:0000250, ECO:0000269|PubMed:14966289}.		actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; myofibril assembly [GO:0030239]	actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; myofibril assembly [GO:0030239]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity). {ECO:0000250}.
Q13049	reviewed	TRI32_HUMAN	E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A)	TRIM32 HT2A	Homo sapiens (Human)	653	FUNCTION: Has an E3 ubiquitin ligase activity (PubMed:19349376, PubMed:31123703). Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation (PubMed:19349376). May ubiquitinate BBS2 (PubMed:22500027). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation (PubMed:31123703). {ECO:0000250|UniProtKB:Q8CH72, ECO:0000269|PubMed:19349376, ECO:0000269|PubMed:22500027, ECO:0000269|PubMed:31123703}.; FUNCTION: (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo (PubMed:7778269). Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo (PubMed:7778269). {ECO:0000269|PubMed:7778269}.		axon development [GO:0061564]; fat cell differentiation [GO:0045444]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of chemokine (C-C motif) ligand 20 production [GO:1903886]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interleukin-17-mediated signaling pathway [GO:1903883]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of proteolysis [GO:0045862]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; suppression of viral release by host [GO:0044790]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; striated muscle myosin thick filament [GO:0005863]	identical protein binding [GO:0042802]; myosin binding [GO:0017022]; protein self-association [GO:0043621]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; translation initiation factor binding [GO:0031369]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; striated muscle myosin thick filament [GO:0005863]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]; protein self-association [GO:0043621]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; translation initiation factor binding [GO:0031369]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; axon development [GO:0061564]; fat cell differentiation [GO:0045444]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of chemokine (C-C motif) ligand 20 production [GO:1903886]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interleukin-17-mediated signaling pathway [GO:1903883]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of proteolysis [GO:0045862]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; suppression of viral release by host [GO:0044790]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19349376}. Note=Localized in cytoplasmic bodies, often located around the nucleus. {ECO:0000269|PubMed:19349376}.
Q13057	reviewed	COASY_HUMAN	Bifunctional coenzyme A synthase (CoA synthase) (NBP) (POV-2) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (DPCOAK)]	COASY PSEC0106	Homo sapiens (Human)	564	FUNCTION: Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:24360804}.		coenzyme A biosynthetic process [GO:0015937]; phosphorylation [GO:0016310]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]	ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140]; pantetheine-phosphate adenylyltransferase activity [GO:0004595]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140]; pantetheine-phosphate adenylyltransferase activity [GO:0004595]; coenzyme A biosynthetic process [GO:0015937]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24360804}. Mitochondrion matrix {ECO:0000269|PubMed:24360804}. Note=The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but is also present in cell lysate. {ECO:0000269|PubMed:24360804}.
Q13061	reviewed	TRDN_HUMAN	Triadin	TRDN	Homo sapiens (Human)	729	FUNCTION: Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000250|UniProtKB:E9Q9K5, ECO:0000269|PubMed:22422768}.		cytoplasmic microtubule organization [GO:0031122]; endoplasmic reticulum membrane organization [GO:0090158]; establishment of localization in cell [GO:0051649]; heart contraction [GO:0060047]; intracellular calcium ion homeostasis [GO:0006874]; muscle contraction [GO:0006936]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901846]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to bacterium [GO:0009617]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]	protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; cytoplasmic microtubule organization [GO:0031122]; endoplasmic reticulum membrane organization [GO:0090158]; establishment of localization in cell [GO:0051649]; heart contraction [GO:0060047]; intracellular calcium ion homeostasis [GO:0006874]; muscle contraction [GO:0006936]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901846]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22422768}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:22422768, ECO:0000269|PubMed:24325401}; Single-pass type II membrane protein {ECO:0000269|PubMed:22422768, ECO:0000269|PubMed:24325401}.
Q13064	reviewed	MKRN3_HUMAN	Probable E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127)	MKRN3 D15S9 RNF63 ZNF127	Homo sapiens (Human)	507	FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. {ECO:0000250, ECO:0000269|PubMed:19066619}.	MISCELLANEOUS: Imprinted, expressed from the paternal chromosome only. A deficiency of MKRN3 is not sufficient to cause Prader-Willi syndrome (PWS).	protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]	ribonucleoprotein complex [GO:1990904]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]	ribonucleoprotein complex [GO:1990904]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]	
Q13075	reviewed	BIRC1_HUMAN	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein)	NAIP BIRC1	Homo sapiens (Human)	1403	FUNCTION: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.; FUNCTION: Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.		apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; icosanoid biosynthetic process [GO:0046456]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nervous system development [GO:0007399]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of JNK cascade [GO:0046330]; pyroptosis [GO:0070269]; regulation of apoptotic process [GO:0042981]	basolateral plasma membrane [GO:0016323]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; IPAF inflammasome complex [GO:0072557]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; metal ion binding [GO:0046872]; protein serine/threonine kinase binding [GO:0120283]	basolateral plasma membrane [GO:0016323]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; IPAF inflammasome complex [GO:0072557]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; metal ion binding [GO:0046872]; protein serine/threonine kinase binding [GO:0120283]; apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; icosanoid biosynthetic process [GO:0046456]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nervous system development [GO:0007399]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of JNK cascade [GO:0046330]; pyroptosis [GO:0070269]; regulation of apoptotic process [GO:0042981]	
Q13077	reviewed	TRAF1_HUMAN	TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)	TRAF1 EBI6	Homo sapiens (Human)	416	FUNCTION: Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. {ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455, ECO:0000269|PubMed:19698991, ECO:0000269|PubMed:20385093}.		apoptotic process [GO:0006915]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein-containing complex assembly [GO:0065003]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]	identical protein binding [GO:0042802]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein-containing complex assembly [GO:0065003]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	
Q13084	reviewed	RM28_HUMAN	Large ribosomal subunit protein bL28m (39S ribosomal protein L28, mitochondrial) (L28mt) (MRP-L28) (Melanoma antigen p15) (Melanoma-associated antigen recognized by T-lymphocytes)	MRPL28 MAAT1	Homo sapiens (Human)	256		MISCELLANEOUS: Potentially represents an important therapeutic reagent for HLA-A24 patients. This antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290 in the context of HLA-A24.	mitochondrial translation [GO:0032543]; translation [GO:0006412]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:28892042}.
Q13085	reviewed	ACACA_HUMAN	Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha)	ACACA ACAC ACC1 ACCA	Homo sapiens (Human)	2346	FUNCTION: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}.		acetyl-CoA metabolic process [GO:0006084]; cellular response to prostaglandin E stimulus [GO:0071380]; fatty acid biosynthetic process [GO:0006633]; fatty-acyl-CoA biosynthetic process [GO:0046949]; lipid homeostasis [GO:0055088]; malonyl-CoA biosynthetic process [GO:2001295]; protein homotetramerization [GO:0051289]; protein metabolic process [GO:0019538]; tissue homeostasis [GO:0001894]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]	acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; acetyl-CoA metabolic process [GO:0006084]; cellular response to prostaglandin E stimulus [GO:0071380]; fatty acid biosynthetic process [GO:0006633]; fatty-acyl-CoA biosynthetic process [GO:0046949]; lipid homeostasis [GO:0055088]; malonyl-CoA biosynthetic process [GO:2001295]; protein homotetramerization [GO:0051289]; protein metabolic process [GO:0019538]; tissue homeostasis [GO:0001894]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5SWU9}.
Q13087	reviewed	PDIA2_HUMAN	Protein disulfide-isomerase A2 (EC 5.3.4.1) (Pancreas-specific protein disulfide isomerase) (PDIp)	PDIA2 PDIP	Homo sapiens (Human)	525	FUNCTION: Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins. {ECO:0000269|PubMed:19150607, ECO:0000269|PubMed:19429457}.		platelet aggregation [GO:0070527]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein retention in ER lumen [GO:0006621]; response to endoplasmic reticulum stress [GO:0034976]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	disulfide oxidoreductase activity [GO:0015036]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; steroid binding [GO:0005496]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; disulfide oxidoreductase activity [GO:0015036]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; steroid binding [GO:0005496]; platelet aggregation [GO:0070527]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein retention in ER lumen [GO:0006621]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q13093	reviewed	PAFA_HUMAN	Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (Group-VIIA phospholipase A2) (gVIIA-PLA2) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase)	PLA2G7 PAFAH	Homo sapiens (Human)	441	FUNCTION: Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:7700381, PubMed:8624782, PubMed:2040620, PubMed:16371369, PubMed:17090529, PubMed:10066756). At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:2040620, PubMed:10504265). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position (PubMed:2040620). Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (PubMed:2040620, PubMed:8624782). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10504265, PubMed:10066756, PubMed:7592717, PubMed:11590221, PubMed:7700381, PubMed:18434304, PubMed:16371369, PubMed:8675689, PubMed:8624782). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects (PubMed:2040620, PubMed:7700381). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (PubMed:17090529). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (PubMed:16371369). {ECO:0000269|PubMed:10066756, ECO:0000269|PubMed:10504265, ECO:0000269|PubMed:11590221, ECO:0000269|PubMed:16371369, ECO:0000269|PubMed:17090529, ECO:0000269|PubMed:18434304, ECO:0000269|PubMed:2040620, ECO:0000269|PubMed:7592717, ECO:0000269|PubMed:7700381, ECO:0000269|PubMed:8624782, ECO:0000269|PubMed:8675689}.		lipid oxidation [GO:0034440]; low-density lipoprotein particle remodeling [GO:0034374]; peptide hormone processing [GO:0016486]; phosphatidylcholine catabolic process [GO:0034638]; plasma lipoprotein particle oxidation [GO:0034441]; platelet activating factor catabolic process [GO:0062234]; platelet activating factor metabolic process [GO:0046469]; positive regulation of inflammatory response [GO:0050729]; positive regulation of monocyte chemotaxis [GO:0090026]	extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium-independent phospholipase A2 activity [GO:0047499]; hydrolase activity, acting on ester bonds [GO:0016788]; phospholipid binding [GO:0005543]	extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium-independent phospholipase A2 activity [GO:0047499]; hydrolase activity, acting on ester bonds [GO:0016788]; phospholipid binding [GO:0005543]; lipid oxidation [GO:0034440]; low-density lipoprotein particle remodeling [GO:0034374]; peptide hormone processing [GO:0016486]; phosphatidylcholine catabolic process [GO:0034638]; plasma lipoprotein particle oxidation [GO:0034441]; platelet activating factor catabolic process [GO:0062234]; platelet activating factor metabolic process [GO:0046469]; positive regulation of inflammatory response [GO:0050729]; positive regulation of monocyte chemotaxis [GO:0090026]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:10066756, ECO:0000269|PubMed:11590221, ECO:0000269|PubMed:12821559, ECO:0000269|PubMed:18434304}. Note=Associates with both LDL and HDL particles in plasma (PubMed:11590221, PubMed:12821559, PubMed:18434304, PubMed:10066756). Mainly associates with pro-inflammatory electronegative LDL particles (PubMed:12821559). {ECO:0000269|PubMed:10066756, ECO:0000269|PubMed:11590221, ECO:0000269|PubMed:12821559, ECO:0000269|PubMed:18434304}.
Q13094	reviewed	LCP2_HUMAN	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)	LCP2	Homo sapiens (Human)	533	FUNCTION: Involved in T-cell antigen receptor mediated signaling.		immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cell-cell junction [GO:0005911]; cytosol [GO:0005829]; plasma membrane raft [GO:0044853]; TCR signalosome [GO:0036398]		cell-cell junction [GO:0005911]; cytosol [GO:0005829]; plasma membrane raft [GO:0044853]; TCR signalosome [GO:0036398]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q13098	reviewed	CSN1_HUMAN	COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)	GPS1 COPS1 CSN1	Homo sapiens (Human)	491	FUNCTION: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.		JNK cascade [GO:0007254]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GTPase inhibitor activity [GO:0005095]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; GTPase inhibitor activity [GO:0005095]; JNK cascade [GO:0007254]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Q13099	reviewed	IFT88_HUMAN	Intraflagellar transport protein 88 homolog (Recessive polycystic kidney disease protein Tg737 homolog) (Tetratricopeptide repeat protein 10) (TPR repeat protein 10)	IFT88 TG737 TTC10	Homo sapiens (Human)	824	FUNCTION: Positively regulates primary cilium biogenesis (PubMed:17604723). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. {ECO:0000250|UniProtKB:Q61371, ECO:0000269|PubMed:17604723}.		cilium assembly [GO:0060271]; inner ear receptor cell stereocilium organization [GO:0060122]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515]; positive regulation of cilium assembly [GO:0045724]; regulation of autophagosome assembly [GO:2000785]; regulation of cilium assembly [GO:1902017]; response to silicon dioxide [GO:0034021]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; sperm flagellum [GO:0036126]	kinesin binding [GO:0019894]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; sperm flagellum [GO:0036126]; kinesin binding [GO:0019894]; cilium assembly [GO:0060271]; inner ear receptor cell stereocilium organization [GO:0060122]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515]; positive regulation of cilium assembly [GO:0045724]; regulation of autophagosome assembly [GO:2000785]; regulation of cilium assembly [GO:1902017]; response to silicon dioxide [GO:0034021]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q61371}. Cell projection, cilium {ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:28428259}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:27767179, ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27767179}. Cytoplasm {ECO:0000250|UniProtKB:Q61371}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q61371}. Note=Colocalizes with ENTR1 and gamma-tubulin at the basal body of primary cilia. Colocalizes with ENTR1 and pericentrin at the centrosome. {ECO:0000269|PubMed:27767179}.
Q13105	reviewed	ZBT17_HUMAN	Zinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60)	ZBTB17 MIZ1 ZNF151 ZNF60	Homo sapiens (Human)	803	FUNCTION: Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946). {ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:25245946, ECO:0000269|PubMed:9308237, ECO:0000269|PubMed:9312026}.		ectoderm development [GO:0007398]; G1 to G0 transition [GO:0070314]; gastrulation with mouth forming second [GO:0001702]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]	core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator binding [GO:0001223]	nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator binding [GO:0001223]; ectoderm development [GO:0007398]; G1 to G0 transition [GO:0070314]; gastrulation with mouth forming second [GO:0001702]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14739298, ECO:0000269|PubMed:9312026}.
Q13107	reviewed	UBP4_HUMAN	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)	USP4 UNP UNPH	Homo sapiens (Human)	963	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16472766, PubMed:16339847, PubMed:20595234, PubMed:22347420, PubMed:25404403, PubMed:28604766, PubMed:30514904). Deubiquitinates PDPK1 (PubMed:22347420). Deubiquitinates TRIM21 (PubMed:16316627). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847). Deubiquitinates HAS2 (PubMed:28604766). Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling (PubMed:30514904). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234). May also play a role in the regulation of quality control in the ER (PubMed:16339847). {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:22347420, ECO:0000269|PubMed:25404403, ECO:0000269|PubMed:28604766, ECO:0000269|PubMed:30514904}.		negative regulation of protein ubiquitination [GO:0031397]; positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; protein localization to cell surface [GO:0034394]; regulation of protein stability [GO:0031647]; spliceosomal tri-snRNP complex assembly [GO:0000244]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	adenosine receptor binding [GO:0031685]; cysteine-type deubiquitinase activity [GO:0004843]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; adenosine receptor binding [GO:0031685]; cysteine-type deubiquitinase activity [GO:0004843]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; protein localization to cell surface [GO:0034394]; regulation of protein stability [GO:0031647]; spliceosomal tri-snRNP complex assembly [GO:0000244]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Nucleus {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type. {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}.
Q13111	reviewed	CAF1A_HUMAN	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150)	CHAF1A CAF CAF1P150	Homo sapiens (Human)	956	FUNCTION: Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. {ECO:0000250|UniProtKB:Q5R1T0}.		cell cycle [GO:0007049]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; nucleosome assembly [GO:0006334]	CAF-1 complex [GO:0033186]; chromatin [GO:0000785]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082]	CAF-1 complex [GO:0033186]; chromatin [GO:0000785]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082]; cell cycle [GO:0007049]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10052459}. Note=DNA replication foci.
Q13112	reviewed	CAF1B_HUMAN	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7)	CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7	Homo sapiens (Human)	559	FUNCTION: Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}.		cell cycle [GO:0007049]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; nucleosome assembly [GO:0006334]	CAF-1 complex [GO:0033186]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; unfolded protein binding [GO:0051082]	CAF-1 complex [GO:0033186]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; unfolded protein binding [GO:0051082]; cell cycle [GO:0007049]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9614144}. Cytoplasm {ECO:0000269|PubMed:9614144}. Note=DNA replication foci. Cytoplasmic in M phase.
Q13113	reviewed	PDZ1I_HUMAN	PDZK1-interacting protein 1 (17 kDa membrane-associated protein) (Protein DD96)	PDZK1IP1 MAP17	Homo sapiens (Human)	114	FUNCTION: May play an important role in tumor biology.			extracellular exosome [GO:0070062]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.
Q13114	reviewed	TRAF3_HUMAN	TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)	TRAF3 CAP-1 CRAF1 TRAFAMN	Homo sapiens (Human)	568	FUNCTION: Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:25847972, PubMed:27980081). Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance (PubMed:27438768). Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819, ECO:0000269|PubMed:25847972, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:32562145, ECO:0000269|PubMed:33148796, ECO:0000269|PubMed:33608556, ECO:0000269|PubMed:34011520}.		apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of type I interferon production [GO:0032481]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; signal transduction [GO:0007165]; Toll signaling pathway [GO:0008063]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type I interferon-mediated signaling pathway [GO:0060337]	CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; mitochondrion [GO:0005739]; serine/threonine protein kinase complex [GO:1902554]; ubiquitin ligase complex [GO:0000151]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; mitochondrion [GO:0005739]; serine/threonine protein kinase complex [GO:1902554]; ubiquitin ligase complex [GO:0000151]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of type I interferon production [GO:0032481]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; signal transduction [GO:0007165]; Toll signaling pathway [GO:0008063]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25847972, ECO:0000269|PubMed:34011520}. Endosome {ECO:0000250|UniProtKB:Q60803}. Mitochondrion {ECO:0000269|PubMed:32562145}. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Co-localized to mitochondria with TRIM35 (PubMed:32562145). {ECO:0000250|UniProtKB:Q60803, ECO:0000269|PubMed:32562145}.
Q13115	reviewed	DUS4_HUMAN	Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)	DUSP4 MKP2 VH2	Homo sapiens (Human)	394	FUNCTION: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. {ECO:0000269|PubMed:7535768}.	MISCELLANEOUS: [Isoform 2]: Does not bind to JNK or ERK, and is more susceptible to proteasomal degradation. {ECO:0000305}.	dephosphorylation [GO:0016311]; endoderm formation [GO:0001706]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/threonine phosphatase activity [GO:0008330]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/threonine phosphatase activity [GO:0008330]; dephosphorylation [GO:0016311]; endoderm formation [GO:0001706]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7535768}.
Q13117	reviewed	DAZ2_HUMAN	Deleted in azoospermia protein 2	DAZ2	Homo sapiens (Human)	558	FUNCTION: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.	MISCELLANEOUS: The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated region of the Y chromosome, in two clusters each comprising an inverted pair of DAZ genes. They are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a DAZ protein involve all the 4 proteins.	3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; positive regulation of translational initiation [GO:0045948]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; positive regulation of translational initiation [GO:0045948]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11058556}. Nucleus {ECO:0000269|PubMed:11058556}. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
Q13118	reviewed	KLF10_HUMAN	Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1)	KLF10 TIEG TIEG1	Homo sapiens (Human)	480	FUNCTION: Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}.		bone mineralization [GO:0030282]; cell-cell signaling [GO:0007267]; cellular response to starvation [GO:0009267]; circadian rhythm [GO:0007623]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]	chromatin [GO:0000785]; nucleus [GO:0005634]	core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; bone mineralization [GO:0030282]; cell-cell signaling [GO:0007267]; cellular response to starvation [GO:0009267]; circadian rhythm [GO:0007623]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O89091}.
Q13123	reviewed	RED_HUMAN	Protein Red (Cytokine IK) (IK factor) (Protein RER)	IK RED RER	Homo sapiens (Human)	557	FUNCTION: Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353). {ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:24252166, ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166, ECO:0000305}.; FUNCTION: (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. {ECO:0000269|PubMed:24945353}.		mitotic cell cycle [GO:0000278]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA splicing, via spliceosome [GO:0000398]; protein localization to kinetochore [GO:0034501]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; U2-type precatalytic spliceosome [GO:0071005]	identical protein binding [GO:0042802]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; U2-type precatalytic spliceosome [GO:0071005]; identical protein binding [GO:0042802]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA splicing, via spliceosome [GO:0000398]; protein localization to kinetochore [GO:0034501]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24252166, ECO:0000269|PubMed:24945353}. Chromosome {ECO:0000269|PubMed:24252166}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:22351768}. Note=Predominantly present throughout the nucleoplasm during prometaphase, metaphase and anaphase. Is also detected in nuclear foci that are not identical with Cajal bodies. Starts to accumulate at chromosomes during telophase, and is nearly exclusively associated with chromosomes in newly divided cells (PubMed:24252166). Colocalizes with MAD1L1 at mitotic spindle poles during metaphase and anaphase (PubMed:22351768). {ECO:0000269|PubMed:24252166}.
Q13126	reviewed	MTAP_HUMAN	S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase)	MTAP MSAP	Homo sapiens (Human)	283	FUNCTION: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. {ECO:0000255|HAMAP-Rule:MF_03155, ECO:0000269|PubMed:3091600}.		L-methionine salvage from methylthioadenosine [GO:0019509]; methylation [GO:0032259]; nucleobase-containing compound metabolic process [GO:0006139]; purine ribonucleoside salvage [GO:0006166]; response to testosterone [GO:0033574]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; S-methyl-5-thioadenosine phosphorylase activity [GO:0017061]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; 1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; S-methyl-5-thioadenosine phosphorylase activity [GO:0017061]; L-methionine salvage from methylthioadenosine [GO:0019509]; methylation [GO:0032259]; nucleobase-containing compound metabolic process [GO:0006139]; purine ribonucleoside salvage [GO:0006166]; response to testosterone [GO:0033574]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03155}.
Q13127	reviewed	REST_HUMAN	RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor)	REST NRSF XBR	Homo sapiens (Human)	1097	FUNCTION: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247, PubMed:11741002, PubMed:11779185). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). {ECO:0000250|UniProtKB:O54963, ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:10449787, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185}.	MISCELLANEOUS: [Isoform 3]: Produced by SRRM4-dependent alternative splicing in neurons and inner ear hair cells (By similarity). Lacks the four C-terminal zinc fingers and the RCOR1 corepressor interaction site found in full length REST isoform 1, which are required for full DNA-binding and repressive activity (PubMed:11741002). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:11741002}.	auditory receptor cell stereocilium organization [GO:0060088]; cardiac muscle cell myoblast differentiation [GO:0060379]; cellular response to electrical stimulus [GO:0071257]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to xenobiotic stimulus [GO:0071466]; chromatin remodeling [GO:0006338]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; hematopoietic progenitor cell differentiation [GO:0002244]; modification of synaptic structure [GO:0099563]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of amniotic stem cell differentiation [GO:2000798]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of dense core granule biogenesis [GO:2000706]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin secretion [GO:0046676]; negative regulation of mesenchymal stem cell differentiation [GO:2000740]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; nervous system process [GO:0050877]; neuromuscular process controlling balance [GO:0050885]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of programmed cell death [GO:0043068]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of DNA-templated transcription [GO:0006355]; regulation of osteoblast differentiation [GO:0045667]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; somatic stem cell population maintenance [GO:0035019]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; auditory receptor cell stereocilium organization [GO:0060088]; cardiac muscle cell myoblast differentiation [GO:0060379]; cellular response to electrical stimulus [GO:0071257]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to xenobiotic stimulus [GO:0071466]; chromatin remodeling [GO:0006338]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; hematopoietic progenitor cell differentiation [GO:0002244]; modification of synaptic structure [GO:0099563]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of amniotic stem cell differentiation [GO:2000798]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of dense core granule biogenesis [GO:2000706]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin secretion [GO:0046676]; negative regulation of mesenchymal stem cell differentiation [GO:2000740]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; nervous system process [GO:0050877]; neuromuscular process controlling balance [GO:0050885]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of programmed cell death [GO:0043068]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of DNA-templated transcription [GO:0006355]; regulation of osteoblast differentiation [GO:0045667]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16442230, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:30684677}. Cytoplasm {ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:30684677}. Note=Colocalizes with ZFP90 in the nucleus (By similarity). In response to hypoxia, there is a more pronounced increase in levels in the nucleus as compared to the cytoplasm (PubMed:27531581). In aging neurons, increased levels in the nucleus as compared to the cytoplasm (PubMed:24670762, PubMed:30684677). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:30684677}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16442230}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:16442230}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:16442230}.
Q13129	reviewed	RLF_HUMAN	Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein)	RLF	Homo sapiens (Human)	1914	FUNCTION: May be involved in transcriptional regulation.	MISCELLANEOUS: In some small cell lung carcinoma (SCLC) cell lines, there is an intrachromosomal rearrangements at 1p32 fusing the first exon of the RLF gene with L-myc.	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA methylation [GO:0044030]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA methylation [GO:0044030]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q13131	reviewed	AAPK1_HUMAN	5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)	PRKAA1 AMPK1	Homo sapiens (Human)	559	FUNCTION: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11554766, PubMed:11518699, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:20074060, PubMed:12519745). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}.		autophagy [GO:0006914]; bile acid and bile salt transport [GO:0015721]; bile acid signaling pathway [GO:0038183]; CAMKK-AMPK signaling cascade [GO:0061762]; cellular response to calcium ion [GO:0071277]; cellular response to ethanol [GO:0071361]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; cellular response to organonitrogen compound [GO:0071417]; cellular response to oxidative stress [GO:0034599]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol biosynthetic process [GO:0006695]; cold acclimation [GO:0009631]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; fatty acid oxidation [GO:0019395]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; intracellular signal transduction [GO:0035556]; lipid biosynthetic process [GO:0008610]; lipid droplet disassembly [GO:1905691]; motor behavior [GO:0061744]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of glucosylceramide biosynthetic process [GO:0046318]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of tubulin deacetylation [GO:1904428]; neuron cellular homeostasis [GO:0070050]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of autophagy [GO:0010508]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of mitochondrial transcription [GO:1903109]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization [GO:1903829]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of skeletal muscle tissue development [GO:0048643]; protein localization to lipid droplet [GO:1990044]; protein phosphorylation [GO:0006468]; regulation of bile acid secretion [GO:0120188]; regulation of circadian rhythm [GO:0042752]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of stress granule assembly [GO:0062028]; regulation of vesicle-mediated transport [GO:0060627]; response to activity [GO:0014823]; response to caffeine [GO:0031000]; response to estrogen [GO:0043627]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]	[acetyl-CoA carboxylase] kinase activity [GO:0050405]; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity [GO:0047322]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; chromatin binding [GO:0003682]; histone H2BS36 kinase activity [GO:0140823]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; [acetyl-CoA carboxylase] kinase activity [GO:0050405]; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity [GO:0047322]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; chromatin binding [GO:0003682]; histone H2BS36 kinase activity [GO:0140823]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; autophagy [GO:0006914]; bile acid and bile salt transport [GO:0015721]; bile acid signaling pathway [GO:0038183]; CAMKK-AMPK signaling cascade [GO:0061762]; cellular response to calcium ion [GO:0071277]; cellular response to ethanol [GO:0071361]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; cellular response to organonitrogen compound [GO:0071417]; cellular response to oxidative stress [GO:0034599]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol biosynthetic process [GO:0006695]; cold acclimation [GO:0009631]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; fatty acid oxidation [GO:0019395]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; intracellular signal transduction [GO:0035556]; lipid biosynthetic process [GO:0008610]; lipid droplet disassembly [GO:1905691]; motor behavior [GO:0061744]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of glucosylceramide biosynthetic process [GO:0046318]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of tubulin deacetylation [GO:1904428]; neuron cellular homeostasis [GO:0070050]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of autophagy [GO:0010508]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of mitochondrial transcription [GO:1903109]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization [GO:1903829]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of skeletal muscle tissue development [GO:0048643]; protein localization to lipid droplet [GO:1990044]; protein phosphorylation [GO:0006468]; regulation of bile acid secretion [GO:0120188]; regulation of circadian rhythm [GO:0042752]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of stress granule assembly [GO:0062028]; regulation of vesicle-mediated transport [GO:0060627]; response to activity [GO:0014823]; response to caffeine [GO:0031000]; response to estrogen [GO:0043627]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15866171}. Nucleus {ECO:0000269|PubMed:15866171}. Note=In response to stress, recruited by p53/TP53 to specific promoters. {ECO:0000269|PubMed:15866171}.
Q13133	reviewed	NR1H3_HUMAN	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)	NR1H3 LXRA	Homo sapiens (Human)	447	FUNCTION: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). {ECO:0000250|UniProtKB:Q9Z0Y9, ECO:0000269|PubMed:19481530, ECO:0000269|PubMed:25661920}.		apoptotic cell clearance [GO:0043277]; cell differentiation [GO:0030154]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; hormone-mediated signaling pathway [GO:0009755]; lipid homeostasis [GO:0055088]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lipid transport [GO:0032369]; negative regulation of macrophage activation [GO:0043031]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of pinocytosis [GO:0048550]; negative regulation of proteolysis [GO:0045861]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of secretion of lysosomal enzymes [GO:0090341]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transporter activity [GO:0032411]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of circadian rhythm [GO:0042752]; response to progesterone [GO:0032570]; sterol homeostasis [GO:0055092]; triglyceride homeostasis [GO:0070328]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575]	cholesterol binding [GO:0015485]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sterol response element binding [GO:0032810]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575]; cholesterol binding [GO:0015485]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sterol response element binding [GO:0032810]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; apoptotic cell clearance [GO:0043277]; cell differentiation [GO:0030154]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; hormone-mediated signaling pathway [GO:0009755]; lipid homeostasis [GO:0055088]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lipid transport [GO:0032369]; negative regulation of macrophage activation [GO:0043031]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of pinocytosis [GO:0048550]; negative regulation of proteolysis [GO:0045861]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of secretion of lysosomal enzymes [GO:0090341]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transporter activity [GO:0032411]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of circadian rhythm [GO:0042752]; response to progesterone [GO:0032570]; sterol homeostasis [GO:0055092]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:25661920}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z0Y9}.
Q13136	reviewed	LIPA1_HUMAN	Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1)	PPFIA1 LIP1	Homo sapiens (Human)	1202	FUNCTION: May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.	MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.	cell-matrix adhesion [GO:0007160]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of stress fiber assembly [GO:0051497]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; signal transduction [GO:0007165]; synapse organization [GO:0050808]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]; spine apparatus [GO:0097444]		axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]; spine apparatus [GO:0097444]; cell-matrix adhesion [GO:0007160]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of stress fiber assembly [GO:0051497]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; signal transduction [GO:0007165]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7796809}. Note=Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus.
Q13137	reviewed	CACO2_HUMAN	Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52)	CALCOCO2 NDP52	Homo sapiens (Human)	446	FUNCTION: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:23022382, ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:25771791}.		positive regulation of autophagosome maturation [GO:1901098]; response to type II interferon [GO:0034341]; selective autophagy [GO:0061912]; viral process [GO:0016032]; xenophagy [GO:0098792]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]	metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; positive regulation of autophagosome maturation [GO:1901098]; response to type II interferon [GO:0034341]; selective autophagy [GO:0061912]; viral process [GO:0016032]; xenophagy [GO:0098792]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12869526, ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:9230084}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17635994}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:25771791}; Peripheral membrane protein {ECO:0000305}. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. {ECO:0000269|PubMed:12869526, ECO:0000269|PubMed:7540613, ECO:0000269|PubMed:9230084}.
Q13144	reviewed	EI2BE_HUMAN	Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon)	EIF2B5 EIF2BE	Homo sapiens (Human)	721	FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.		astrocyte development [GO:0014002]; astrocyte differentiation [GO:0048708]; hippocampus development [GO:0021766]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic process [GO:0043065]; positive regulation of translational initiation [GO:0045948]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; nucleus [GO:0005634]	guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; nucleus [GO:0005634]; guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]; astrocyte development [GO:0014002]; astrocyte differentiation [GO:0048708]; hippocampus development [GO:0021766]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic process [GO:0043065]; positive regulation of translational initiation [GO:0045948]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	
Q13145	reviewed	BAMBI_HUMAN	BMP and activin membrane-bound inhibitor homolog (Non-metastatic gene A protein) (Putative transmembrane protein NMA)	BAMBI NMA	Homo sapiens (Human)	260	FUNCTION: Negatively regulates TGF-beta signaling.		cell migration [GO:0016477]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of protein binding [GO:0032092]; regulation of cell shape [GO:0008360]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	frizzled binding [GO:0005109]; type II transforming growth factor beta receptor binding [GO:0005114]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; frizzled binding [GO:0005109]; type II transforming growth factor beta receptor binding [GO:0005114]; cell migration [GO:0016477]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of protein binding [GO:0032092]; regulation of cell shape [GO:0008360]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q13148	reviewed	TADBP_HUMAN	TAR DNA-binding protein 43 (TDP-43)	TARDBP TDP43	Homo sapiens (Human)	414	FUNCTION: RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:23398327, PubMed:19765185). Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; amyloid fibril formation [GO:1990000]; mRNA processing [GO:0006397]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; nuclear inner membrane organization [GO:0071765]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein import into nucleus [GO:0042307]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380]	cytoplasmic stress granule [GO:0010494]; interchromatin granule [GO:0035061]; intracellular non-membrane-bounded organelle [GO:0043232]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]	DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasmic stress granule [GO:0010494]; interchromatin granule [GO:0035061]; intracellular non-membrane-bounded organelle [GO:0043232]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; amyloid fibril formation [GO:1990000]; mRNA processing [GO:0006397]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; nuclear inner membrane organization [GO:0071765]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein import into nucleus [GO:0042307]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17023659, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:18957508, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:28663553, ECO:0000269|PubMed:29438978}. Cytoplasm {ECO:0000269|PubMed:18957508, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:30464263}. Cytoplasm, Stress granule {ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:23398327}. Mitochondrion {ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:33031745}. Note=Continuously travels in and out of the nucleus (PubMed:18957508). Localizes to stress granules in response to oxidative stress (PubMed:19765185). A small subset localizes in mitochondria (PubMed:28794432). {ECO:0000269|PubMed:18957508, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:28794432}.
Q13151	reviewed	ROA0_HUMAN	Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0)	HNRNPA0 HNRPA0	Homo sapiens (Human)	305	FUNCTION: mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}.		3'-UTR-mediated mRNA stabilization [GO:0070935]; inflammatory response [GO:0006954]; mRNA processing [GO:0006397]; response to lipopolysaccharide [GO:0032496]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]	mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; inflammatory response [GO:0006954]; mRNA processing [GO:0006397]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Component of ribonucleosomes. {ECO:0000250}.
Q13153	reviewed	PAK1_HUMAN	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)	PAK1	Homo sapiens (Human)	545	FUNCTION: Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9395435, PubMed:9032240). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}.		actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration [GO:0016477]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; ephrin receptor signaling pathway [GO:0048013]; exocytosis [GO:0006887]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; intracellular signal transduction [GO:0035556]; localization [GO:0051179]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; neuron projection morphogenesis [GO:0048812]; phosphorylation [GO:0016310]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein autophosphorylation [GO:0046777]; protein localization to cytoplasmic stress granule [GO:1903608]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axonogenesis [GO:0050770]; regulation of MAPK cascade [GO:0043408]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; wound healing [GO:0042060]	actin filament [GO:0005884]; axon [GO:0030424]; cell-cell junction [GO:0005911]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; microtubule organizing center [GO:0005815]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; Z disc [GO:0030018]	ATP binding [GO:0005524]; collagen binding [GO:0005518]; gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actin filament [GO:0005884]; axon [GO:0030424]; cell-cell junction [GO:0005911]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; microtubule organizing center [GO:0005815]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; Z disc [GO:0030018]; ATP binding [GO:0005524]; collagen binding [GO:0005518]; gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration [GO:0016477]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; ephrin receptor signaling pathway [GO:0048013]; exocytosis [GO:0006887]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; intracellular signal transduction [GO:0035556]; localization [GO:0051179]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; neuron projection morphogenesis [GO:0048812]; phosphorylation [GO:0016310]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein autophosphorylation [GO:0046777]; protein localization to cytoplasmic stress granule [GO:1903608]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axonogenesis [GO:0050770]; regulation of MAPK cascade [GO:0043408]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:25766321}. Cell junction, focal adhesion {ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:25766321}. Cell projection, lamellipodium {ECO:0000269|PubMed:11896197}. Cell membrane {ECO:0000269|PubMed:25766321}. Cell projection, ruffle membrane {ECO:0000269|PubMed:25766321}. Cell projection, invadopodium {ECO:0000269|PubMed:25766321}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23260667}. Chromosome {ECO:0000269|PubMed:23260667}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27012601}. Note=Colocalizes with RUFY3, F-actin and other core migration components in invadopodia at the cell periphery (PubMed:25766321). Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212 where is co-recruited with MORC2 on damaged chromatin (PubMed:23260667). Localization to the centrosome does not depend upon the presence of gamma-tubulin (PubMed:27012601). Localization of the active, but not inactive, protein to the adhesions and edge of lamellipodia is mediated by interaction with GIT1 (PubMed:11896197). {ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601}.
Q13155	reviewed	AIMP2_HUMAN	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1)	AIMP2 JTV1 PRO0992	Homo sapiens (Human)	320	FUNCTION: Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:19131329}.	MISCELLANEOUS: Accumulates in brains affected by autosomal-recessive juvenile parkinsonism, idiopathic Parkinson disease and diffuse Lewy body disease.	apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; translation [GO:0006412]; type II pneumocyte differentiation [GO:0060510]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	molecular adaptor activity [GO:0060090]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; molecular adaptor activity [GO:0060090]; apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; translation [GO:0006412]; type II pneumocyte differentiation [GO:0060510]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}. Nucleus {ECO:0000250|UniProtKB:Q8R010}. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. {ECO:0000250|UniProtKB:Q8R010}.
Q13156	reviewed	RFA4_HUMAN	Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4)	RPA4	Homo sapiens (Human)	261	FUNCTION: As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. {ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19942684, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:20545304}.		DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; double-strand break repair via homologous recombination [GO:0000724]; nucleotide-excision repair [GO:0006289]	chromosome, telomeric region [GO:0000781]; DNA replication factor A complex [GO:0005662]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	single-stranded DNA binding [GO:0003697]; telomeric DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; DNA replication factor A complex [GO:0005662]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; single-stranded DNA binding [GO:0003697]; telomeric DNA binding [GO:0042162]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; double-strand break repair via homologous recombination [GO:0000724]; nucleotide-excision repair [GO:0006289]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19942684}. Note=Localizes to DNA repair foci after DNA damage.
Q13158	reviewed	FADD_HUMAN	FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)	FADD MORT1 GIG3	Homo sapiens (Human)	208	FUNCTION: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors (PubMed:7538907, PubMed:23955153, PubMed:19118384, PubMed:20935634, PubMed:16762833, PubMed:24025841). The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation (PubMed:7538907, PubMed:19118384, PubMed:20935634, PubMed:16762833). Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (PubMed:16762833). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (PubMed:21109225). {ECO:0000269|PubMed:16762833, ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:20935634, ECO:0000269|PubMed:21109225, ECO:0000269|PubMed:23955153, ECO:0000269|PubMed:24025841, ECO:0000269|PubMed:7538907}.		activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; behavioral response to cocaine [GO:0048148]; cellular response to mechanical stimulus [GO:0071260]; death-inducing signaling complex assembly [GO:0071550]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; innate immune response [GO:0045087]; kidney development [GO:0001822]; lymph node development [GO:0048535]; motor neuron apoptotic process [GO:0097049]; necroptotic signaling pathway [GO:0097527]; negative regulation of activation-induced cell death of T cells [GO:0070236]; negative regulation of necroptotic process [GO:0060546]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [GO:2000454]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of proteolysis [GO:0045862]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of type II interferon production [GO:0032729]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; plasma membrane [GO:0005886]; ripoptosome [GO:0097342]	caspase binding [GO:0089720]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; receptor serine/threonine kinase binding [GO:0033612]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]	CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; plasma membrane [GO:0005886]; ripoptosome [GO:0097342]; caspase binding [GO:0089720]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; receptor serine/threonine kinase binding [GO:0033612]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]; activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; behavioral response to cocaine [GO:0048148]; cellular response to mechanical stimulus [GO:0071260]; death-inducing signaling complex assembly [GO:0071550]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; innate immune response [GO:0045087]; kidney development [GO:0001822]; lymph node development [GO:0048535]; motor neuron apoptotic process [GO:0097049]; necroptotic signaling pathway [GO:0097527]; negative regulation of activation-induced cell death of T cells [GO:0070236]; negative regulation of necroptotic process [GO:0060546]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [GO:2000454]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of proteolysis [GO:0045862]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of type II interferon production [GO:0032729]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	
Q13162	reviewed	PRDX4_HUMAN	Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4)	PRDX4	Homo sapiens (Human)	271	FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. {ECO:0000269|PubMed:9388242}.	MISCELLANEOUS: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin. {ECO:0000305|PubMed:21994946}.	cell redox homeostasis [GO:0045454]; extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; I-kappaB phosphorylation [GO:0007252]; male gonad development [GO:0008584]; negative regulation of male germ cell proliferation [GO:2000255]; protein maturation by protein folding [GO:0022417]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]	identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular sequestering activity [GO:0140313]; thioredoxin peroxidase activity [GO:0008379]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular sequestering activity [GO:0140313]; thioredoxin peroxidase activity [GO:0008379]; cell redox homeostasis [GO:0045454]; extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; I-kappaB phosphorylation [GO:0007252]; male gonad development [GO:0008584]; negative regulation of male germ cell proliferation [GO:2000255]; protein maturation by protein folding [GO:0022417]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18052930, ECO:0000269|PubMed:9388242}. Endoplasmic reticulum {ECO:0000269|PubMed:18052930}. Note=Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic. {ECO:0000269|PubMed:18052930}.
Q13163	reviewed	MP2K5_HUMAN	Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)	MAP2K5 MEK5 MKK5 PRKMK5	Homo sapiens (Human)	448	FUNCTION: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. {ECO:0000269|PubMed:7759517, ECO:0000269|PubMed:9384584}.	MISCELLANEOUS: [Isoform C]: Incomplete sequence. {ECO:0000305}.	cellular response to growth factor stimulus [GO:0071363]; cellular response to laminar fluid shear stress [GO:0071499]; ERK5 cascade [GO:0070375]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; MAPK cascade [GO:0000165]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphorylation [GO:0016310]; positive regulation of cell growth [GO:0030307]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]	spindle [GO:0005819]	ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	spindle [GO:0005819]; ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; cellular response to growth factor stimulus [GO:0071363]; cellular response to laminar fluid shear stress [GO:0071499]; ERK5 cascade [GO:0070375]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; MAPK cascade [GO:0000165]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphorylation [GO:0016310]; positive regulation of cell growth [GO:0030307]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]	
Q13164	reviewed	MK07_HUMAN	Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)	MAPK7 BMK1 ERK5 PRKM7	Homo sapiens (Human)	816	FUNCTION: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.		calcineurin-NFAT signaling cascade [GO:0033173]; cAMP-mediated signaling [GO:0019933]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to transforming growth factor beta stimulus [GO:0071560]; intracellular signal transduction [GO:0035556]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of response to cytokine stimulus [GO:0060761]; phosphorylation [GO:0016310]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; regulation of angiogenesis [GO:0045765]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; mitogen-activated protein kinase binding [GO:0051019]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; mitogen-activated protein kinase binding [GO:0051019]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; calcineurin-NFAT signaling cascade [GO:0033173]; cAMP-mediated signaling [GO:0019933]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to transforming growth factor beta stimulus [GO:0071560]; intracellular signal transduction [GO:0035556]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of response to cytokine stimulus [GO:0060761]; phosphorylation [GO:0016310]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; regulation of angiogenesis [GO:0045765]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation.
Q13177	reviewed	PAK2_HUMAN	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]	PAK2	Homo sapiens (Human)	524	FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:7744004, PubMed:19273597, PubMed:19923322, PubMed:9171063, PubMed:12853446, PubMed:16617111, PubMed:33693784). Acts as downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:9171063, PubMed:12853446, PubMed:16617111). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}.		adherens junction assembly [GO:0034333]; apoptotic process [GO:0006915]; bicellular tight junction assembly [GO:0070830]; cardiac muscle hypertrophy [GO:0003300]; cellular response to organic cyclic compound [GO:0071407]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dendritic spine development [GO:0060996]; intracellular signal transduction [GO:0035556]; localization [GO:0051179]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress fiber assembly [GO:0051497]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein autophosphorylation [GO:0046777]; protein localization to cell-cell junction [GO:0150105]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of cytoskeleton organization [GO:0051493]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; secretory granule [GO:0030141]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activator activity [GO:0030296]; small GTPase binding [GO:0031267]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; secretory granule [GO:0030141]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activator activity [GO:0030296]; small GTPase binding [GO:0031267]; adherens junction assembly [GO:0034333]; apoptotic process [GO:0006915]; bicellular tight junction assembly [GO:0070830]; cardiac muscle hypertrophy [GO:0003300]; cellular response to organic cyclic compound [GO:0071407]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dendritic spine development [GO:0060996]; intracellular signal transduction [GO:0035556]; localization [GO:0051179]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress fiber assembly [GO:0051497]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein autophosphorylation [GO:0046777]; protein localization to cell-cell junction [GO:0150105]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of cytoskeleton organization [GO:0051493]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: [Serine/threonine-protein kinase PAK 2]: Cytoplasm {ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21555521}. Nucleus {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:21555521}. Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane. {ECO:0000269|PubMed:19923322}.; SUBCELLULAR LOCATION: [PAK-2p34]: Nucleus {ECO:0000269|PubMed:12853446}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15471851}. Membrane {ECO:0000269|PubMed:16617111}; Lipid-anchor {ECO:0000269|PubMed:16617111}. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region (PubMed:15471851). Myristoylation changes PAK-2p34 location to the membrane (PubMed:16617111). {ECO:0000269|PubMed:15471851, ECO:0000269|PubMed:16617111}.
Q13183	reviewed	S13A2_HUMAN	Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter)	SLC13A2 NADC1 SDCT1	Homo sapiens (Human)	592	FUNCTION: Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:10894787, PubMed:9668069, PubMed:8967342). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:8967342, PubMed:9668069, PubMed:10894787). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:10894787). Has a critical role in renal dicarboxylate transport (By similarity). {ECO:0000250|UniProtKB:Q9ES88, ECO:0000269|PubMed:10894787, ECO:0000269|PubMed:8967342, ECO:0000269|PubMed:9668069}.		alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; fumarate transport [GO:0015741]; succinate transmembrane transport [GO:0071422]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; fumarate transmembrane transporter activity [GO:0015138]; low-affinity sodium:dicarboxylate symporter activity [GO:0015361]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; fumarate transmembrane transporter activity [GO:0015138]; low-affinity sodium:dicarboxylate symporter activity [GO:0015361]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]; alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; fumarate transport [GO:0015741]; succinate transmembrane transport [GO:0071422]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:27927654}; Multi-pass membrane protein {ECO:0000255}.
Q13185	reviewed	CBX3_HUMAN	Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)	CBX3	Homo sapiens (Human)	183	FUNCTION: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:28167679}.		chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; rhythmic process [GO:0048511]	chromatin [GO:0000785]; chromatin lock complex [GO:0061793]; chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; condensed chromosome, centromeric region [GO:0000779]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; RNA polymerase II transcription regulator complex [GO:0090575]; site of DNA damage [GO:0090734]; spindle [GO:0005819]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; protein domain specific binding [GO:0019904]; transcription coregulator binding [GO:0001221]	chromatin [GO:0000785]; chromatin lock complex [GO:0061793]; chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; condensed chromosome, centromeric region [GO:0000779]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; RNA polymerase II transcription regulator complex [GO:0090575]; site of DNA damage [GO:0090734]; spindle [GO:0005819]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; protein domain specific binding [GO:0019904]; transcription coregulator binding [GO:0001221]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28977666}. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). {ECO:0000305}.
Q13188	reviewed	STK3_HUMAN	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]	STK3 KRS1 MST2	Homo sapiens (Human)	491	FUNCTION: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38. {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}.		apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation involved in embryonic placenta development [GO:0060706]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; organ growth [GO:0035265]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein binding [GO:0032092]; primitive hemopoiesis [GO:0060215]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; regulation of MAPK cascade [GO:0043408]; selective autophagy [GO:0061912]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation involved in embryonic placenta development [GO:0060706]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; organ growth [GO:0035265]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein binding [GO:0032092]; primitive hemopoiesis [GO:0060215]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; regulation of MAPK cascade [GO:0043408]; selective autophagy [GO:0061912]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21145499}. Nucleus {ECO:0000269|PubMed:21145499}. Note=The caspase-cleaved form cycles between nucleus and cytoplasm (PubMed:19525978, PubMed:11278283). Phosphorylation at Thr-117 leads to inhibition of nuclear translocation (PubMed:19525978). {ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:19525978}.
Q13190	reviewed	STX5_HUMAN	Syntaxin-5	STX5 STX5A	Homo sapiens (Human)	355	FUNCTION: Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q08851}.; FUNCTION: (Microbial infection) Required for the efficient production of infectious virion during human cytomegalovirus infection. Mechanistically, participates in the formation of the cytoplasmic viral assembly compartment where tegument acquisition and envelopment occur. {ECO:0000269|PubMed:27795424}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at Met-55 of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing and alternative initiation. {ECO:0000305}.	early endosome to Golgi transport [GO:0034498]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi disassembly [GO:0090166]; intracellular protein transport [GO:0006886]; positive regulation of protein catabolic process [GO:0045732]; regulation of Golgi organization [GO:1903358]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]; vesicle fusion with Golgi apparatus [GO:0048280]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; SNARE complex [GO:0031201]; vesicle [GO:0031982]	cadherin binding [GO:0045296]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; SNARE complex [GO:0031201]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; early endosome to Golgi transport [GO:0034498]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi disassembly [GO:0090166]; intracellular protein transport [GO:0006886]; positive regulation of protein catabolic process [GO:0045732]; regulation of Golgi organization [GO:1903358]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]; vesicle fusion with Golgi apparatus [GO:0048280]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q08851}; Single-pass type IV membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:27795424}. Note=Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. {ECO:0000269|PubMed:27795424}.
Q13191	reviewed	CBLB_HUMAN	E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)	CBLB RNF56 Nbla00127	Homo sapiens (Human)	982	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.	MISCELLANEOUS: This protein has one functional calcium-binding site. {ECO:0000250}.	CD4-positive, alpha-beta T cell proliferation [GO:0035739]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of T cell receptor signaling pathway [GO:0050860]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell anergy [GO:0002669]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; signal transduction [GO:0007165]; T cell anergy [GO:0002870]; T cell receptor signaling pathway [GO:0050852]	cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of T cell receptor signaling pathway [GO:0050860]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell anergy [GO:0002669]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; signal transduction [GO:0007165]; T cell anergy [GO:0002870]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12177062}. Note=Upon EGF stimulation, associates with endocytic vesicles.
Q13200	reviewed	PSMD2_HUMAN	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)	PSMD2 TRAP2	Homo sapiens (Human)	908	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, base subcomplex [GO:0008540]; proteasome storage granule [GO:0034515]; secretory granule lumen [GO:0034774]	enzyme regulator activity [GO:0030234]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, base subcomplex [GO:0008540]; proteasome storage granule [GO:0034515]; secretory granule lumen [GO:0034774]; enzyme regulator activity [GO:0030234]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176]	
Q13201	reviewed	MMRN1_HUMAN	Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)]	MMRN1 ECM EMILIN4 GPIA* MMRN	Homo sapiens (Human)	1228	FUNCTION: Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. {ECO:0000269|PubMed:16363244, ECO:0000269|PubMed:19132231, ECO:0000269|PubMed:7629143}.		blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; negative regulation of wound healing [GO:0061045]; positive regulation of platelet aggregation [GO:1901731]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; multimerin complex [GO:1990972]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]	calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; multimerin complex [GO:1990972]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; negative regulation of wound healing [GO:0061045]; positive regulation of platelet aggregation [GO:1901731]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q13202	reviewed	DUS8_HUMAN	Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5)	DUSP8 C11orf81 VH5	Homo sapiens (Human)	625	FUNCTION: Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues. {ECO:0000250|UniProtKB:O09112}.		dephosphorylation [GO:0016311]; negative regulation of MAPK cascade [GO:0043409]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine/threonine phosphatase activity [GO:0008330]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine/threonine phosphatase activity [GO:0008330]; dephosphorylation [GO:0016311]; negative regulation of MAPK cascade [GO:0043409]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O09112}. Nucleus {ECO:0000250|UniProtKB:O09112}.
Q13206	reviewed	DDX10_HUMAN	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10)	DDX10	Homo sapiens (Human)	875	FUNCTION: Putative ATP-dependent RNA helicase.		anterior head development [GO:0097065]; rRNA processing [GO:0006364]	nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; anterior head development [GO:0097065]; rRNA processing [GO:0006364]	
Q13207	reviewed	TBX2_HUMAN	T-box transcription factor TBX2 (T-box protein 2)	TBX2	Homo sapiens (Human)	712	FUNCTION: Transcription factor which acts as a transcriptional repressor (PubMed:11111039, PubMed:11062467, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}.		aorta morphogenesis [GO:0035909]; apoptotic process [GO:0006915]; atrioventricular canal development [GO:0036302]; atrioventricular canal morphogenesis [GO:1905222]; cardiac jelly development [GO:1905072]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac muscle tissue development [GO:0048738]; cell fate specification [GO:0001708]; cellular senescence [GO:0090398]; cochlea morphogenesis [GO:0090103]; developmental growth involved in morphogenesis [GO:0060560]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube development [GO:0035050]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart looping [GO:0001947]; mammary placode formation [GO:0060596]; melanocyte proliferation [GO:0097325]; mesenchymal cell proliferation involved in lung development [GO:0060916]; muscle cell fate determination [GO:0007521]; negative regulation of cardiac chamber formation [GO:1901211]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of heart looping [GO:1901208]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pharynx development [GO:0060465]; pigment metabolic process involved in pigmentation [GO:0043474]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart contraction [GO:0008016]; regulation of transcription by RNA polymerase II [GO:0006357]; response to retinoic acid [GO:0032526]; roof of mouth development [GO:0060021]; smooth muscle cell differentiation [GO:0051145]; ureteric peristalsis [GO:0072105]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; aorta morphogenesis [GO:0035909]; apoptotic process [GO:0006915]; atrioventricular canal development [GO:0036302]; atrioventricular canal morphogenesis [GO:1905222]; cardiac jelly development [GO:1905072]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac muscle tissue development [GO:0048738]; cell fate specification [GO:0001708]; cellular senescence [GO:0090398]; cochlea morphogenesis [GO:0090103]; developmental growth involved in morphogenesis [GO:0060560]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube development [GO:0035050]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart looping [GO:0001947]; mammary placode formation [GO:0060596]; melanocyte proliferation [GO:0097325]; mesenchymal cell proliferation involved in lung development [GO:0060916]; muscle cell fate determination [GO:0007521]; negative regulation of cardiac chamber formation [GO:1901211]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of heart looping [GO:1901208]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pharynx development [GO:0060465]; pigment metabolic process involved in pigmentation [GO:0043474]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart contraction [GO:0008016]; regulation of transcription by RNA polymerase II [GO:0006357]; response to retinoic acid [GO:0032526]; roof of mouth development [GO:0060021]; smooth muscle cell differentiation [GO:0051145]; ureteric peristalsis [GO:0072105]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29726930, ECO:0000305|PubMed:11111039}.
Q13214	reviewed	SEM3B_HUMAN	Semaphorin-3B (Sema A(V)) (Semaphorin-V) (Sema V)	SEMA3B SEMA5 SEMAA	Homo sapiens (Human)	749	FUNCTION: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. {ECO:0000250}.		axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; chemorepulsion of axon [GO:0061643]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; chemorepulsion of axon [GO:0061643]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Endoplasmic reticulum. Note=Accumulates in the endoplasmic reticulum.
Q13216	reviewed	ERCC8_HUMAN	DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)	ERCC8 CKN1 CSA	Homo sapiens (Human)	396	FUNCTION: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair; involved in repair of DSSBs by non-homologous end joining (NHEJ) (PubMed:29545921). {ECO:0000269|PubMed:16751180, ECO:0000269|PubMed:16916636, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29545921}.		DNA damage response [GO:0006974]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; positive regulation of DNA repair [GO:0045739]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of transcription-coupled nucleotide-excision repair [GO:0090262]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; transcription-coupled nucleotide-excision repair [GO:0006283]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	protein-containing complex binding [GO:0044877]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-containing complex binding [GO:0044877]; DNA damage response [GO:0006974]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; positive regulation of DNA repair [GO:0045739]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of transcription-coupled nucleotide-excision repair [GO:0090262]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; transcription-coupled nucleotide-excision repair [GO:0006283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Nucleus matrix {ECO:0000269|PubMed:26620705}. Note=UV-induced translocation to the nuclear matrix is dependent on ERCC6. {ECO:0000269|PubMed:26620705}.
Q13217	reviewed	DNJC3_HUMAN	DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)	DNAJC3 P58IPK PRKRI	Homo sapiens (Human)	504	FUNCTION: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. {ECO:0000250|UniProtKB:Q27968, ECO:0000250|UniProtKB:Q91YW3, ECO:0000269|PubMed:12601012, ECO:0000269|PubMed:8576172, ECO:0000269|PubMed:9447982, ECO:0000269|PubMed:9920933}.		cellular response to cold [GO:0070417]; defense response to virus [GO:0051607]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; positive regulation of translation initiation in response to endoplasmic reticulum stress [GO:0036494]; protein folding in endoplasmic reticulum [GO:0034975]; proteolysis involved in protein catabolic process [GO:0051603]; response to unfolded protein [GO:0006986]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; smooth endoplasmic reticulum [GO:0005790]	misfolded protein binding [GO:0051787]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein-folding chaperone binding [GO:0051087]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; smooth endoplasmic reticulum [GO:0005790]; misfolded protein binding [GO:0051787]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein-folding chaperone binding [GO:0051087]; cellular response to cold [GO:0070417]; defense response to virus [GO:0051607]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; positive regulation of translation initiation in response to endoplasmic reticulum stress [GO:0036494]; protein folding in endoplasmic reticulum [GO:0034975]; proteolysis involved in protein catabolic process [GO:0051603]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}.
Q13219	reviewed	PAPP1_HUMAN	Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A)	PAPPA	Homo sapiens (Human)	1627	FUNCTION: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10913121, ECO:0000269|PubMed:11522292}.		cell surface receptor signaling pathway [GO:0007166]; female pregnancy [GO:0007565]; protein catabolic process [GO:0030163]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]; response to dexamethasone [GO:0071548]; response to follicle-stimulating hormone [GO:0032354]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; cell surface receptor signaling pathway [GO:0007166]; female pregnancy [GO:0007565]; protein catabolic process [GO:0030163]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]; response to dexamethasone [GO:0071548]; response to follicle-stimulating hormone [GO:0032354]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10077652}.
Q13224	reviewed	NMDE2_HUMAN	Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)	GRIN2B NMDAR2B	Homo sapiens (Human)	1484	FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:8768735}.		brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; chemical synaptic transmission [GO:0007268]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of dendritic spine maintenance [GO:1902951]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein heterotetramerization [GO:0051290]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to ethanol [GO:0045471]; synaptic transmission, glutamatergic [GO:0035249]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; late endosome [GO:0005770]; lysosome [GO:0005764]; neuron projection [GO:0043005]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synaptic membrane [GO:0097060]	amyloid-beta binding [GO:0001540]; glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; glycine binding [GO:0016594]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; late endosome [GO:0005770]; lysosome [GO:0005764]; neuron projection [GO:0043005]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synaptic membrane [GO:0097060]; amyloid-beta binding [GO:0001540]; glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; glycine binding [GO:0016594]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; zinc ion binding [GO:0008270]; brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; chemical synaptic transmission [GO:0007268]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of dendritic spine maintenance [GO:1902951]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein heterotetramerization [GO:0051290]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to ethanol [GO:0045471]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:8768735}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q00960}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00960}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q00960}. Late endosome {ECO:0000250|UniProtKB:Q01097}. Lysosome {ECO:0000250|UniProtKB:Q01097}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q01097}. Note=Co-localizes with the motor protein KIF17 along microtubules. {ECO:0000250|UniProtKB:Q01097}.
Q13227	reviewed	GPS2_HUMAN	G protein pathway suppressor 2 (GPS-2)	GPS2	Homo sapiens (Human)	327	FUNCTION: Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:24943844). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:19858209, PubMed:24943844). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (PubMed:20159957). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (By similarity). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the pro-inflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity (By similarity). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT (By similarity). Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). Acts as a tumor-suppressor in liposarcoma (PubMed:27460081). {ECO:0000250|UniProtKB:Q921N8, ECO:0000269|PubMed:19481530, ECO:0000269|PubMed:19858209, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:27460081, ECO:0000269|PubMed:29499132, ECO:0000269|PubMed:8943324}.; FUNCTION: (Microbial infection) Required for efficient replication of hepatitis C virus (HCV) by promoting the interaction between VAPA and HCV virus protein NS5A. {ECO:0000269|PubMed:24223774}.		B cell differentiation [GO:0030183]; JNK cascade [GO:0007254]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of inflammatory response [GO:0050728]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of fat cell differentiation [GO:0045598]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription by RNA polymerase II [GO:0006357]; response to mitochondrial depolarisation [GO:0098780]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]	cyclin binding [GO:0030332]; GTPase inhibitor activity [GO:0005095]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]; cyclin binding [GO:0030332]; GTPase inhibitor activity [GO:0005095]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; B cell differentiation [GO:0030183]; JNK cascade [GO:0007254]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of inflammatory response [GO:0050728]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of fat cell differentiation [GO:0045598]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription by RNA polymerase II [GO:0006357]; response to mitochondrial depolarisation [GO:0098780]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19858209, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:29499132}. Mitochondrion {ECO:0000269|PubMed:29499132}. Cytoplasm, cytosol {ECO:0000269|PubMed:24223774, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:29499132}. Note=Sumoylation regulates the subcellular location (PubMed:24943844). Relocates from the mitochondria to the nucleus following desumoylation, leading to mediate mitochondrial stress response (By similarity). {ECO:0000250|UniProtKB:Q921N8, ECO:0000269|PubMed:24943844}.
Q13228	reviewed	SBP1_HUMAN	Methanethiol oxidase (MTO) (EC 1.8.3.4) (56 kDa selenium-binding protein) (SBP56) (SP56) (Selenium-binding protein 1)	SELENBP1 SBP	Homo sapiens (Human)	472	FUNCTION: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity). {ECO:0000250|UniProtKB:Q8VIF7, ECO:0000269|PubMed:29255262}.		protein transport [GO:0015031]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]	methanethiol oxidase activity [GO:0018549]; selenium binding [GO:0008430]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; methanethiol oxidase activity [GO:0018549]; selenium binding [GO:0008430]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14991897}. Cytoplasm, cytosol {ECO:0000269|PubMed:14991897, ECO:0000269|PubMed:16223876}. Membrane {ECO:0000250|UniProtKB:Q8VIF7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VIF7}. Note=May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity). {ECO:0000250|UniProtKB:Q8VIF7}.
Q13231	reviewed	CHIT1_HUMAN	Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1)	CHIT1	Homo sapiens (Human)	466	FUNCTION: Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. {ECO:0000269|PubMed:7592832, ECO:0000269|PubMed:7836450}.	MISCELLANEOUS: Very high plasma levels of CHIT1 are found in patients with Gaucher disease type 1 (GD I). Can be used as diagnostic aid and to evaluate the success of treatment that brings levels back to normal.; MISCELLANEOUS: [Isoform 3]: Duplication of 24 bp in exon 10 leads to the use of a cryptic splice site. The normal splice site is still present but not used. {ECO:0000305}.	chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; polysaccharide digestion [GO:0044245]; response to bacterium [GO:0009617]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	chitin binding [GO:0008061]; chitinase activity [GO:0004568]; endochitinase activity [GO:0008843]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; chitin binding [GO:0008061]; chitinase activity [GO:0004568]; endochitinase activity [GO:0008843]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; polysaccharide digestion [GO:0044245]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Secreted. Lysosome. Note=A small proportion is lysosomal.
Q13232	reviewed	NDK3_HUMAN	Nucleoside diphosphate kinase 3 (NDK 3) (NDP kinase 3) (EC 2.7.4.6) (DR-nm23) (Nucleoside diphosphate kinase C) (NDPKC) (nm23-H3)	NME3	Homo sapiens (Human)	169	FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.		apoptotic process [GO:0006915]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; phosphorylation [GO:0016310]; UTP biosynthetic process [GO:0006228]	cytosol [GO:0005829]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]	cytosol [GO:0005829]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]; apoptotic process [GO:0006915]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; phosphorylation [GO:0016310]; UTP biosynthetic process [GO:0006228]	
Q13233	reviewed	M3K1_HUMAN	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)	MAP3K1 MAPKKK1 MEKK MEKK1	Homo sapiens (Human)	1512	FUNCTION: Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}.		cellular response to mechanical stimulus [GO:0071260]; Fc-epsilon receptor signaling pathway [GO:0038095]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]; cellular response to mechanical stimulus [GO:0071260]; Fc-epsilon receptor signaling pathway [GO:0038095]; protein phosphorylation [GO:0006468]	
Q13237	reviewed	KGP2_HUMAN	cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII)	PRKG2 PRKGR2	Homo sapiens (Human)	762	FUNCTION: Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000250|UniProtKB:Q64595, ECO:0000269|PubMed:33106379}.		negative regulation of chloride transport [GO:2001226]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of protein localization [GO:1903829]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; tetrahydrobiopterin metabolic process [GO:0046146]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]	ATP binding [GO:0005524]; cGMP binding [GO:0030553]; cGMP-dependent protein kinase activity [GO:0004692]; identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; ATP binding [GO:0005524]; cGMP binding [GO:0030553]; cGMP-dependent protein kinase activity [GO:0004692]; identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; negative regulation of chloride transport [GO:2001226]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of protein localization [GO:1903829]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; tetrahydrobiopterin metabolic process [GO:0046146]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:8636133}; Lipid-anchor {ECO:0000269|PubMed:8636133}.
Q13239	reviewed	SLAP1_HUMAN	Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP)	SLA SLAP SLAP1	Homo sapiens (Human)	276	FUNCTION: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:10449770, ECO:0000269|PubMed:11696592}.		regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}. Note=Colocalizes with endosomes. {ECO:0000250}.
Q13241	reviewed	KLRD1_HUMAN	Natural killer cells antigen CD94 (KP43) (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94)	KLRD1 CD94	Homo sapiens (Human)	179	FUNCTION: Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules (PubMed:9486650, PubMed:10023772, PubMed:18083576, PubMed:18064301, PubMed:9754572, PubMed:37264229). Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:9430220, PubMed:12387742, PubMed:18064301). Primarily functions as a ligand binding subunit as it lacks the capacity to signal. {ECO:0000269|PubMed:10023772, ECO:0000269|PubMed:12387742, ECO:0000269|PubMed:18064301, ECO:0000269|PubMed:18083576, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9430220, ECO:0000269|PubMed:9486650, ECO:0000269|PubMed:9754572}.; FUNCTION: KLRD1-KLRC1 acts as an immune inhibitory receptor. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:9486650, PubMed:9430220, PubMed:9485206, PubMed:30860984). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984). Upon HLA-E-peptide binding, transmits intracellular signals through KLRC1 immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHIP-1 and INPPL1/SHIP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:9485206, PubMed:12165520). {ECO:0000269|PubMed:12165520, ECO:0000269|PubMed:12387742, ECO:0000269|PubMed:18064301, ECO:0000269|PubMed:30503213, ECO:0000269|PubMed:30860984, ECO:0000269|PubMed:9430220, ECO:0000269|PubMed:9485206, ECO:0000269|PubMed:9486650}.; FUNCTION: KLRD1-KLRC2 acts as an immune activating receptor (PubMed:9655483, PubMed:15940674). On cytotoxic lymphocyte subsets recognizes HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed:21825173, PubMed:20952657). Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed:9655483, PubMed:15940674). {ECO:0000269|PubMed:15940674, ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:21825173, ECO:0000269|PubMed:30134159, ECO:0000269|PubMed:9655483, ECO:0000269|PubMed:9754572}.; FUNCTION: (Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells. Recognizes HLA-E in complex with human cytomegalovirus UL40-derived peptide (VMAPRTLIL) and inhibits NK cell cytotoxicity. {ECO:0000269|PubMed:10669413, ECO:0000269|PubMed:23335510}.; FUNCTION: (Microbial infection) May recognize HLA-E in complex with HIV-1 gag/Capsid protein p24-derived peptide (AISPRTLNA) on infected cells and may inhibit NK cell cytotoxicity, a mechanism that allows HIV-1 to escape immune recognition. {ECO:0000269|PubMed:15751767}.; FUNCTION: (Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells (PubMed:32859121). On NK cells, may recognize HLA-E in complex with SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening antiviral immune surveillance (PubMed:32859121). {ECO:0000269|PubMed:32859121}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; natural killer cell mediated immunity [GO:0002228]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	carbohydrate binding [GO:0030246]; HLA-E specific inhibitory MHC class Ib receptor activity [GO:0062082]; MHC class I protein complex binding [GO:0023024]; MHC class Ib protein binding, via antigen binding groove [GO:0023030]; protein antigen binding [GO:1990405]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; carbohydrate binding [GO:0030246]; HLA-E specific inhibitory MHC class Ib receptor activity [GO:0062082]; MHC class I protein complex binding [GO:0023024]; MHC class Ib protein binding, via antigen binding groove [GO:0023030]; protein antigen binding [GO:1990405]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; natural killer cell mediated immunity [GO:0002228]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:9485206}; Single-pass type II membrane protein {ECO:0000255}.
Q13242	reviewed	SRSF9_HUMAN	Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9)	SRSF9 SFRS9 SRP30C	Homo sapiens (Human)	221	FUNCTION: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}.		alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; response to alkaloid [GO:0043279]; response to toxic substance [GO:0009636]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; response to alkaloid [GO:0043279]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11694584, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611}. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells.
Q13243	reviewed	SRSF5_HUMAN	Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)	SRSF5 HRS SFRS5 SRP40	Homo sapiens (Human)	272	FUNCTION: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.	MISCELLANEOUS: [Isoform SRP40-2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus.
Q13247	reviewed	SRSF6_HUMAN	Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)	SRSF6 SFRS6 SRP55	Homo sapiens (Human)	344	FUNCTION: Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}.		alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of keratinocyte proliferation [GO:0010837]; regulation of wound healing [GO:0061041]; response to insulin [GO:0032868]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of keratinocyte proliferation [GO:0010837]; regulation of wound healing [GO:0061041]; response to insulin [GO:0032868]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:22767602}. Nucleus speckle {ECO:0000269|PubMed:22767602}.
Q13253	reviewed	NOGG_HUMAN	Noggin	NOG	Homo sapiens (Human)	232	FUNCTION: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732). {ECO:0000269|PubMed:12478285, ECO:0000269|PubMed:21976273, ECO:0000269|PubMed:26643732}.		atrial cardiac muscle tissue morphogenesis [GO:0055009]; axial mesoderm development [GO:0048318]; BMP signaling pathway [GO:0030509]; cartilage development [GO:0051216]; cell differentiation in hindbrain [GO:0021533]; cranial skeletal system development [GO:1904888]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal joint morphogenesis [GO:0060272]; embryonic skeletal system development [GO:0048706]; endocardial cushion formation [GO:0003272]; endoderm formation [GO:0001706]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; exploration behavior [GO:0035640]; face morphogenesis [GO:0060325]; fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [GO:0060825]; heart trabecula morphogenesis [GO:0061384]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; long-term synaptic potentiation [GO:0060291]; lung morphogenesis [GO:0060425]; membranous septum morphogenesis [GO:0003149]; mesoderm formation [GO:0001707]; middle ear morphogenesis [GO:0042474]; motor neuron axon guidance [GO:0008045]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac epithelial to mesenchymal transition [GO:0062044]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell migration [GO:0030336]; negative regulation of cytokine activity [GO:0060302]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural plate morphogenesis [GO:0001839]; neural tube closure [GO:0001843]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; pharyngeal arch artery morphogenesis [GO:0061626]; pituitary gland development [GO:0021983]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerulus development [GO:0090193]; positive regulation of transcription by RNA polymerase II [GO:0045944]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; prostatic bud formation [GO:0060513]; regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [GO:2000313]; regulation of neuronal synaptic plasticity [GO:0048168]; short-term synaptic potentiation [GO:1990926]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; somatic stem cell population maintenance [GO:0035019]; somite development [GO:0061053]; spinal cord development [GO:0021510]; stem cell differentiation [GO:0048863]; ureteric bud formation [GO:0060676]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]; visual learning [GO:0008542]; wound healing [GO:0042060]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; presynapse [GO:0098793]	cytokine binding [GO:0019955]; protein homodimerization activity [GO:0042803]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; presynapse [GO:0098793]; cytokine binding [GO:0019955]; protein homodimerization activity [GO:0042803]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; axial mesoderm development [GO:0048318]; BMP signaling pathway [GO:0030509]; cartilage development [GO:0051216]; cell differentiation in hindbrain [GO:0021533]; cranial skeletal system development [GO:1904888]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal joint morphogenesis [GO:0060272]; embryonic skeletal system development [GO:0048706]; endocardial cushion formation [GO:0003272]; endoderm formation [GO:0001706]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; exploration behavior [GO:0035640]; face morphogenesis [GO:0060325]; fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [GO:0060825]; heart trabecula morphogenesis [GO:0061384]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; long-term synaptic potentiation [GO:0060291]; lung morphogenesis [GO:0060425]; membranous septum morphogenesis [GO:0003149]; mesoderm formation [GO:0001707]; middle ear morphogenesis [GO:0042474]; motor neuron axon guidance [GO:0008045]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac epithelial to mesenchymal transition [GO:0062044]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell migration [GO:0030336]; negative regulation of cytokine activity [GO:0060302]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural plate morphogenesis [GO:0001839]; neural tube closure [GO:0001843]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; pharyngeal arch artery morphogenesis [GO:0061626]; pituitary gland development [GO:0021983]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerulus development [GO:0090193]; positive regulation of transcription by RNA polymerase II [GO:0045944]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; prostatic bud formation [GO:0060513]; regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [GO:2000313]; regulation of neuronal synaptic plasticity [GO:0048168]; short-term synaptic potentiation [GO:1990926]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; somatic stem cell population maintenance [GO:0035019]; somite development [GO:0061053]; spinal cord development [GO:0021510]; stem cell differentiation [GO:0048863]; ureteric bud formation [GO:0060676]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]; visual learning [GO:0008542]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Secreted.
Q13255	reviewed	GRM1_HUMAN	Metabotropic glutamate receptor 1 (mGluR1)	GRM1 GPRC1A MGLUR1	Homo sapiens (Human)	1194	FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890). May function in the light response in the retina (By similarity). {ECO:0000250|UniProtKB:P97772, ECO:0000269|PubMed:24603153, ECO:0000269|PubMed:28886343, ECO:0000269|PubMed:7476890}.		cellular response to electrical stimulus [GO:0071257]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; G protein-coupled receptor signaling pathway [GO:0007186]; L-glutamate import across plasma membrane [GO:0098712]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of MAPK cascade [GO:0043410]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]	dendrite [GO:0030425]; G protein-coupled receptor dimeric complex [GO:0038037]; G protein-coupled receptor homodimeric complex [GO:0038038]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0098872]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583]	dendrite [GO:0030425]; G protein-coupled receptor dimeric complex [GO:0038037]; G protein-coupled receptor homodimeric complex [GO:0038038]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0098872]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583]; cellular response to electrical stimulus [GO:0071257]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; G protein-coupled receptor signaling pathway [GO:0007186]; L-glutamate import across plasma membrane [GO:0098712]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of MAPK cascade [GO:0043410]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24603153}; Multi-pass membrane protein {ECO:0000269|PubMed:24603153}.
Q13257	reviewed	MD2L1_HUMAN	Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1)	MAD2L1 MAD2	Homo sapiens (Human)	205	FUNCTION: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:29162720, PubMed:15024386). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 (PubMed:29162720). Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (PubMed:10700282, PubMed:11804586, PubMed:15024386). {ECO:0000269|PubMed:10700282, ECO:0000269|PubMed:11804586, ECO:0000269|PubMed:15024386, ECO:0000269|PubMed:29162720}.		cell division [GO:0051301]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; mitotic spindle [GO:0072686]; mitotic spindle assembly checkpoint MAD1-MAD2 complex [GO:1990728]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; mitotic spindle [GO:0072686]; mitotic spindle assembly checkpoint MAD1-MAD2 complex [GO:1990728]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; cell division [GO:0051301]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19010891}. Chromosome, centromere, kinetochore. Cytoplasm {ECO:0000269|PubMed:19010891}. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2. Kinetochore association is repressed by UBD. Sequestered to the cytoplasm upon interaction with isoform 3 of MAD1L1 (PubMed:19010891). {ECO:0000269|PubMed:19010891, ECO:0000305}.
Q13258	reviewed	PD2R_HUMAN	Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor)	PTGDR	Homo sapiens (Human)	359	FUNCTION: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). {ECO:0000250|UniProtKB:P70263, ECO:0000250|UniProtKB:Q9R261}.		adenosine metabolic process [GO:0046085]; cellular response to prostaglandin D stimulus [GO:0071799]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; male sex determination [GO:0030238]; mast cell degranulation [GO:0043303]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; sleep [GO:0030431]	membrane [GO:0016020]; plasma membrane [GO:0005886]	prostaglandin D receptor activity [GO:0004956]; prostaglandin J receptor activity [GO:0001785]	membrane [GO:0016020]; plasma membrane [GO:0005886]; prostaglandin D receptor activity [GO:0004956]; prostaglandin J receptor activity [GO:0001785]; adenosine metabolic process [GO:0046085]; cellular response to prostaglandin D stimulus [GO:0071799]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; male sex determination [GO:0030238]; mast cell degranulation [GO:0043303]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; sleep [GO:0030431]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q13261	reviewed	I15RA_HUMAN	Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)]	IL15RA	Homo sapiens (Human)	267	FUNCTION: High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910). {ECO:0000250|UniProtKB:Q60819, ECO:0000269|PubMed:10480910, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:8530383}.; FUNCTION: [Isoform 5]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.; FUNCTION: [Isoform 6]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.; FUNCTION: [Isoform 7]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.; FUNCTION: [Isoform 8]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.		interleukin-15-mediated signaling pathway [GO:0035723]; natural killer cell differentiation [GO:0001779]; negative regulation of neuron projection development [GO:0010977]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phagocytosis [GO:0050766]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to nutrient levels [GO:0031667]	cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	cytokine receptor activity [GO:0004896]; interleukin-15 receptor activity [GO:0042010]; protein kinase binding [GO:0019901]	cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; cytokine receptor activity [GO:0004896]; interleukin-15 receptor activity [GO:0042010]; protein kinase binding [GO:0019901]; interleukin-15-mediated signaling pathway [GO:0035723]; natural killer cell differentiation [GO:0001779]; negative regulation of neuron projection development [GO:0010977]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phagocytosis [GO:0050766]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to nutrient levels [GO:0031667]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10480910}; Single-pass type I membrane protein {ECO:0000269|PubMed:10480910}. Nucleus membrane {ECO:0000269|PubMed:10480910}; Single-pass type I membrane protein {ECO:0000269|PubMed:10480910}. Cell surface {ECO:0000269|PubMed:15123770}. Note=Mainly found associated with the nuclear membrane.; SUBCELLULAR LOCATION: [Isoform 5]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; SUBCELLULAR LOCATION: [Isoform 6]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; SUBCELLULAR LOCATION: [Isoform 7]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; SUBCELLULAR LOCATION: [Isoform 8]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; SUBCELLULAR LOCATION: [Soluble interleukin-15 receptor subunit alpha]: Secreted, extracellular space {ECO:0000269|PubMed:15265897}.
Q13263	reviewed	TIF1B_HUMAN	Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)	TRIM28 KAP1 RNF96 TIF1B	Homo sapiens (Human)	835	FUNCTION: Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}.		chromatin organization [GO:0006325]; convergent extension involved in axis elongation [GO:0060028]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; post-fertilization epigenetic regulation of gene expression [GO:0043045]; protein sumoylation [GO:0016925]; suppression of viral release by host [GO:0044790]	euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; promoter-specific chromatin binding [GO:1990841]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; promoter-specific chromatin binding [GO:1990841]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; convergent extension involved in axis elongation [GO:0060028]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; post-fertilization epigenetic regulation of gene expression [GO:0043045]; protein sumoylation [GO:0016925]; suppression of viral release by host [GO:0044790]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10330177, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24741090, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:9016654}. Note=Associated with centromeric heterochromatin during cell differentiation through CBX1 (By similarity). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:25593309}.
Q13268	reviewed	DHRS2_HUMAN	Dehydrogenase/reductase SDR family member 2, mitochondrial (EC 1.1.1.-) (Dicarbonyl reductase HEP27) (Protein D) (Short chain dehydrogenase/reductase family 25C member 1) (Protein SDR25C1)	DHRS2 SDR25C1	Homo sapiens (Human)	280	FUNCTION: NADPH-dependent oxidoreductase which catalyzes the reduction of dicarbonyl compounds. Displays reductase activity in vitro with 3,4-hexanedione, 2,3-heptanedione and 1-phenyl-1,2-propanedione as substrates (PubMed:16685466). May function as a dicarbonyl reductase in the enzymatic inactivation of reactive carbonyls involved in covalent modification of cellular components (PubMed:16685466). Also displays a minor hydroxysteroid dehydrogenase activity toward bile acids such as ursodeoxycholic acid (UDCA) and isoursodeoxycholic acid (isoUDCA), which makes it unlikely to control hormone levels (PubMed:16685466). Doesn't show any activity in vitro with retinoids and sugars as substrates (PubMed:16685466). Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21 (PubMed:20547751). Reduces proliferation, migration and invasion of cancer cells and well as the production of ROS in cancer (PubMed:29106393). {ECO:0000269|PubMed:16685466, ECO:0000269|PubMed:20547751, ECO:0000269|PubMed:29106393}.		C21-steroid hormone metabolic process [GO:0008207]; cellular response to oxidative stress [GO:0034599]; electron transport chain [GO:0022900]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; response to toxic substance [GO:0009636]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	carbonyl reductase (NADPH) activity [GO:0004090]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; carbonyl reductase (NADPH) activity [GO:0004090]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; C21-steroid hormone metabolic process [GO:0008207]; cellular response to oxidative stress [GO:0034599]; electron transport chain [GO:0022900]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
Q13275	reviewed	SEM3F_HUMAN	Semaphorin-3F (Sema III/F) (Semaphorin IV) (Sema IV)	SEMA3F	Homo sapiens (Human)	785	FUNCTION: May play a role in cell motility and cell adhesion.		axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; facial nerve structural organization [GO:0021612]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; positive regulation of cell migration [GO:0030335]; regulation of postsynapse organization [GO:0099175]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal nerve structural organization [GO:0021637]; ventral trunk neural crest cell migration [GO:0036486]	extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; facial nerve structural organization [GO:0021612]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; positive regulation of cell migration [GO:0030335]; regulation of postsynapse organization [GO:0099175]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal nerve structural organization [GO:0021637]; ventral trunk neural crest cell migration [GO:0036486]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q13277	reviewed	STX3_HUMAN	Syntaxin-3	STX3 STX3A	Homo sapiens (Human)	289	FUNCTION: Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles. {ECO:0000269|PubMed:24726755}.; FUNCTION: [Isoform B]: Essential for survival of retinal photoreceetors. {ECO:0000269|PubMed:33974130}.; FUNCTION: [Isoform 3]: Functions as a regulator of gene expression. {ECO:0000269|PubMed:29475951}.		exocytic insertion of neurotransmitter receptor to postsynaptic membrane [GO:0098967]; intracellular protein transport [GO:0006886]; long-term synaptic potentiation [GO:0060291]; neuron projection development [GO:0031175]; organelle membrane fusion [GO:0090174]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of gene expression [GO:0010468]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]	apical plasma membrane [GO:0016324]; azurophil granule [GO:0042582]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; neuron projection [GO:0043005]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; SNARE complex [GO:0031201]; specific granule [GO:0042581]; synaptic vesicle [GO:0008021]; vacuole [GO:0005773]; zymogen granule membrane [GO:0042589]	arachidonic acid binding [GO:0050544]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	apical plasma membrane [GO:0016324]; azurophil granule [GO:0042582]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; neuron projection [GO:0043005]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; SNARE complex [GO:0031201]; specific granule [GO:0042581]; synaptic vesicle [GO:0008021]; vacuole [GO:0005773]; zymogen granule membrane [GO:0042589]; arachidonic acid binding [GO:0050544]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; exocytic insertion of neurotransmitter receptor to postsynaptic membrane [GO:0098967]; intracellular protein transport [GO:0006886]; long-term synaptic potentiation [GO:0060291]; neuron projection development [GO:0031175]; organelle membrane fusion [GO:0090174]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of gene expression [GO:0010468]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]	SUBCELLULAR LOCATION: [Isoform A]: Apical cell membrane {ECO:0000269|PubMed:24726755}; Single-pass type IV membrane protein {ECO:0000305}. Note=Localized to the inner and outer plexiform layers, the cell body and the inner segments of photoreceptors. {ECO:0000250|UniProtKB:Q64704}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:29475951}.
Q13283	reviewed	G3BP1_HUMAN	Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)	G3BP1 G3BP	Homo sapiens (Human)	466	FUNCTION: Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36183834, PubMed:36279435, PubMed:34739333, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36692217, PubMed:36279435). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Enhances also RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of stress granule assembly [GO:0062029]; positive regulation of type I interferon production [GO:0032481]; Ras protein signal transduction [GO:0007265]; stress granule assembly [GO:0034063]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perikaryon [GO:0043204]; ribonucleoprotein complex [GO:1990904]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA/RNA helicase activity [GO:0033677]; endonuclease activity [GO:0004519]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perikaryon [GO:0043204]; ribonucleoprotein complex [GO:1990904]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA/RNA helicase activity [GO:0033677]; endonuclease activity [GO:0004519]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of stress granule assembly [GO:0062029]; positive regulation of type I interferon production [GO:0032481]; Ras protein signal transduction [GO:0007265]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:30510222}. Perikaryon {ECO:0000250|UniProtKB:P97855}. Cytoplasm, Stress granule {ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30404792, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572}. Nucleus {ECO:0000269|PubMed:11604510}. Note=Cytoplasmic in proliferating cells (PubMed:11604510). Cytosolic and partially nuclear in resting cells (PubMed:11604510). Recruited to stress granules in response to arsenite treatment (PubMed:12642610, PubMed:20180778). The unphosphorylated form is recruited to stress granules (PubMed:12642610). HRAS signaling contributes to this process by regulating G3BP dephosphorylation (PubMed:12642610). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778}.
Q13285	reviewed	STF1_HUMAN	Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP)	NR5A1 AD4BP FTZF1 SF1	Homo sapiens (Human)	461	FUNCTION: Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000250|UniProtKB:P33242, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:27378692, ECO:0000269|PubMed:28459839}.		adrenal gland development [GO:0030325]; calcineurin-mediated signaling [GO:0097720]; female gonad development [GO:0008585]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; maintenance of protein location in nucleus [GO:0051457]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; negative regulation of female gonad development [GO:2000195]; positive regulation of gene expression [GO:0010628]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary sex determination [GO:0007538]; regulation of steroid biosynthetic process [GO:0050810]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gonadotropin-releasing hormone [GO:0097210]; Sertoli cell differentiation [GO:0060008]; sex determination [GO:0007530]; tissue development [GO:0009888]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; nuclear receptor activity [GO:0004879]; phospholipid binding [GO:0005543]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; nuclear receptor activity [GO:0004879]; phospholipid binding [GO:0005543]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]; adrenal gland development [GO:0030325]; calcineurin-mediated signaling [GO:0097720]; female gonad development [GO:0008585]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; maintenance of protein location in nucleus [GO:0051457]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; negative regulation of female gonad development [GO:2000195]; positive regulation of gene expression [GO:0010628]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary sex determination [GO:0007538]; regulation of steroid biosynthetic process [GO:0050810]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gonadotropin-releasing hormone [GO:0097210]; Sertoli cell differentiation [GO:0060008]; sex determination [GO:0007530]; tissue development [GO:0009888]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:11479297, ECO:0000269|PubMed:27490115}.
Q13286	reviewed	CLN3_HUMAN	Battenin (Batten disease protein) (Protein CLN3)	CLN3 BTS	Homo sapiens (Human)	438	FUNCTION: Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission (PubMed:10924275, PubMed:18817525, PubMed:18317235, PubMed:22261744, PubMed:15471887, PubMed:20850431). Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing (PubMed:10924275, PubMed:18817525). Moreover regulates CTSD activity in response to osmotic stress (PubMed:23840424, PubMed:28390177). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis (PubMed:18317235). At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex (PubMed:20850431). Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory (By similarity). Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process (By similarity). Participates also in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis (PubMed:17482562). {ECO:0000250|UniProtKB:Q61124, ECO:0000269|PubMed:10924275, ECO:0000269|PubMed:15471887, ECO:0000269|PubMed:17482562, ECO:0000269|PubMed:18317235, ECO:0000269|PubMed:18817525, ECO:0000269|PubMed:20850431, ECO:0000269|PubMed:22261744, ECO:0000269|PubMed:23840424, ECO:0000269|PubMed:28390177}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; action potential [GO:0001508]; amyloid precursor protein catabolic process [GO:0042987]; associative learning [GO:0008306]; autophagosome maturation [GO:0097352]; autophagosome-lysosome fusion [GO:0061909]; blood vessel endothelial cell migration [GO:0043534]; glycerophospholipid biosynthetic process [GO:0046474]; glycolipid transport [GO:0046836]; Golgi to lysosome transport [GO:0090160]; intracellular water homeostasis [GO:0009992]; ionotropic glutamate receptor signaling pathway [GO:0035235]; L-arginine transmembrane transport [GO:1903826]; learning or memory [GO:0007611]; lysosomal lumen acidification [GO:0007042]; lysosomal lumen pH elevation [GO:0035752]; lysosomal protein catabolic process [GO:1905146]; lysosome organization [GO:0007040]; membrane organization [GO:0061024]; negative regulation of apoptotic process [GO:0043066]; negative regulation of catalytic activity [GO:0043086]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of proteolysis [GO:0045861]; neuromuscular process controlling balance [GO:0050885]; neurotransmitter metabolic process [GO:0042133]; phagosome-lysosome docking [GO:0090384]; phagosome-lysosome fusion [GO:0090385]; plasma membrane raft organization [GO:0044857]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of pinocytosis [GO:0048549]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to plasma membrane [GO:0072659]; protein processing [GO:0016485]; receptor-mediated endocytosis [GO:0006898]; regulation of arginine biosynthetic process [GO:1900079]; regulation of autophagosome maturation [GO:1901096]; regulation of autophagosome size [GO:0016243]; regulation of cellular response to osmotic stress [GO:0106049]; regulation of cytoskeleton organization [GO:0051493]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of fibroblast migration [GO:0010762]; regulation of filopodium assembly [GO:0051489]; regulation of modification of synaptic structure [GO:1905244]; regulation of phagosome maturation [GO:1905162]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein processing [GO:0070613]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic transmission, GABAergic [GO:0032228]; regulation of synaptic transmission, glutamatergic [GO:0051966]; renal potassium excretion [GO:0036359]; vesicle transport along microtubule [GO:0047496]	autolysosome [GO:0044754]; autophagosome [GO:0005776]; caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]	calcium-dependent protein binding [GO:0048306]; glycolipid binding [GO:0051861]; sulfatide binding [GO:0120146]	autolysosome [GO:0044754]; autophagosome [GO:0005776]; caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; calcium-dependent protein binding [GO:0048306]; glycolipid binding [GO:0051861]; sulfatide binding [GO:0120146]; actin cytoskeleton organization [GO:0030036]; action potential [GO:0001508]; amyloid precursor protein catabolic process [GO:0042987]; associative learning [GO:0008306]; autophagosome maturation [GO:0097352]; autophagosome-lysosome fusion [GO:0061909]; blood vessel endothelial cell migration [GO:0043534]; glycerophospholipid biosynthetic process [GO:0046474]; glycolipid transport [GO:0046836]; Golgi to lysosome transport [GO:0090160]; intracellular water homeostasis [GO:0009992]; ionotropic glutamate receptor signaling pathway [GO:0035235]; L-arginine transmembrane transport [GO:1903826]; learning or memory [GO:0007611]; lysosomal lumen acidification [GO:0007042]; lysosomal lumen pH elevation [GO:0035752]; lysosomal protein catabolic process [GO:1905146]; lysosome organization [GO:0007040]; membrane organization [GO:0061024]; negative regulation of apoptotic process [GO:0043066]; negative regulation of catalytic activity [GO:0043086]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of proteolysis [GO:0045861]; neuromuscular process controlling balance [GO:0050885]; neurotransmitter metabolic process [GO:0042133]; phagosome-lysosome docking [GO:0090384]; phagosome-lysosome fusion [GO:0090385]; plasma membrane raft organization [GO:0044857]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of pinocytosis [GO:0048549]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to plasma membrane [GO:0072659]; protein processing [GO:0016485]; receptor-mediated endocytosis [GO:0006898]; regulation of arginine biosynthetic process [GO:1900079]; regulation of autophagosome maturation [GO:1901096]; regulation of autophagosome size [GO:0016243]; regulation of cellular response to osmotic stress [GO:0106049]; regulation of cytoskeleton organization [GO:0051493]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of fibroblast migration [GO:0010762]; regulation of filopodium assembly [GO:0051489]; regulation of modification of synaptic structure [GO:1905244]; regulation of phagosome maturation [GO:1905162]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein processing [GO:0070613]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic transmission, GABAergic [GO:0032228]; regulation of synaptic transmission, glutamatergic [GO:0051966]; renal potassium excretion [GO:0036359]; vesicle transport along microtubule [GO:0047496]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:10332042, ECO:0000269|PubMed:14644441, ECO:0000269|PubMed:15471887, ECO:0000269|PubMed:15598649, ECO:0000269|PubMed:17286803, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:23840424}; Multi-pass membrane protein {ECO:0000269|PubMed:17286803, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:9949212}. Late endosome {ECO:0000269|PubMed:10332042, ECO:0000269|PubMed:15471887, ECO:0000269|PubMed:17286803, ECO:0000269|PubMed:23840424}. Lysosome {ECO:0000269|PubMed:10332042, ECO:0000269|PubMed:10924275, ECO:0000269|PubMed:14699076, ECO:0000269|PubMed:19941651, ECO:0000269|PubMed:9949212}. Golgi apparatus {ECO:0000269|PubMed:10332042, ECO:0000269|PubMed:15240864, ECO:0000269|PubMed:23840424}. Golgi apparatus membrane {ECO:0000269|PubMed:9949212}. Golgi apparatus, Golgi stack {ECO:0000269|PubMed:15240864}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:10332042, ECO:0000269|PubMed:15240864}. Cell membrane {ECO:0000269|PubMed:14644441, ECO:0000269|PubMed:15240864}. Recycling endosome {ECO:0000269|PubMed:15240864}. Membrane raft {ECO:0000269|PubMed:15240864, ECO:0000269|PubMed:23840424}. Membrane, caveola {ECO:0000269|PubMed:23840424}. Early endosome membrane {ECO:0000269|PubMed:23840424}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q61124}. Late endosome membrane {ECO:0000250|UniProtKB:Q61124}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q61124}. Note=CLN3 is not present in late endosomes/lysosomes in fibroblasts and neurons (PubMed:15240864). Trafficks from cell membrane to Golgi via endosomes (PubMed:15240864). Osmotic stress changes the subcellular localization of CLN3 (PubMed:23840424). Trafficks to intracellular compartments via the plasma membranet through AP3M1-dependent mechanisms (PubMed:14644441). Excluded from the synaptic vesicles (By similarity). {ECO:0000250|UniProtKB:Q61124, ECO:0000269|PubMed:14644441, ECO:0000269|PubMed:15240864, ECO:0000269|PubMed:23840424}.
Q13287	reviewed	NMI_HUMAN	N-myc-interactor (Nmi) (N-myc and STAT interactor)	NMI	Homo sapiens (Human)	307	FUNCTION: Acts as a signaling pathway regulator involved in innate immune system response (PubMed:9989503, PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis (PubMed:9989503, PubMed:29377960). Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription (PubMed:9989503). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 (PubMed:10779520, PubMed:10950963). In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21 (PubMed:26342464). In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (By similarity). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion (PubMed:29038465). Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465). {ECO:0000250|UniProtKB:O35309, ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:29350881, ECO:0000269|PubMed:9989503}.		innate immune response [GO:0045087]; macrophage activation involved in immune response [GO:0002281]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to virus [GO:0009615]; toll-like receptor 4 signaling pathway [GO:0034142]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; innate immune response [GO:0045087]; macrophage activation involved in immune response [GO:0002281]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to virus [GO:0009615]; toll-like receptor 4 signaling pathway [GO:0034142]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:29377960, ECO:0000269|PubMed:9781816}. Nucleus {ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:9781816}. Secreted {ECO:0000269|PubMed:29038465}. Note=Cytoplasmic NMI localizes in punctate granular structures (PubMed:9781816, PubMed:10950963). Nuclear localization increased following IFN-alpha treatment (PubMed:9781816, PubMed:10950963). Extracelullar following secretion by macrophage (PubMed:29038465). {ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:9781816}.
Q13291	reviewed	SLAF1_HUMAN	Signaling lymphocytic activation molecule (CDw150) (IPO-3) (SLAM family member 1) (CD antigen CD150)	SLAMF1 SLAM	Homo sapiens (Human)	335	FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (By similarity). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102). May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity). Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396). {ECO:0000250|UniProtKB:Q9QUM4, ECO:0000269|PubMed:16317102, ECO:0000269|PubMed:20231852, ECO:0000269|PubMed:20818396, ECO:0000305|PubMed:11806999, ECO:0000305|PubMed:12458214}.; FUNCTION: (Microbial infection) Acts as a receptor for Measles virus; also including isoform 4. {ECO:0000269|PubMed:10972291, ECO:0000269|PubMed:25710480}.		adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; innate immune response [GO:0045087]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; myeloid dendritic cell activation involved in immune response [GO:0002277]; natural killer cell differentiation [GO:0001779]; natural killer cell proliferation [GO:0001787]; negative regulation of CD40 signaling pathway [GO:2000349]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; phagocytosis [GO:0006909]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of type II interferon production [GO:0032729]; regulation of vesicle fusion [GO:0031338]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335]	antigen binding [GO:0003823]; identical protein binding [GO:0042802]; SH2 domain binding [GO:0042169]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335]; antigen binding [GO:0003823]; identical protein binding [GO:0042802]; SH2 domain binding [GO:0042169]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]; adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; innate immune response [GO:0045087]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; myeloid dendritic cell activation involved in immune response [GO:0002277]; natural killer cell differentiation [GO:0001779]; natural killer cell proliferation [GO:0001787]; negative regulation of CD40 signaling pathway [GO:2000349]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; phagocytosis [GO:0006909]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of type II interferon production [GO:0032729]; regulation of vesicle fusion [GO:0031338]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11806999}; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells. Located at the plasma membrane contacts between neighboring T-cells (PubMed:11806999). {ECO:0000269|PubMed:11806999}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305|PubMed:7617038}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000305|PubMed:25710480}. Note=Overexpressed isoform 4 is detected on the cell surface. In glioma cell lines endogenuous isoform 4 is detetced predominantly in the cytoplasm and colocalized with endoplasmic reticulum and Golgi markers. {ECO:0000269|PubMed:25710480}.
Q13303	reviewed	KCAB2_HUMAN	Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2)	KCNAB2 KCNA2B KCNK2	Homo sapiens (Human)	367	FUNCTION: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity). {ECO:0000250|UniProtKB:P62482, ECO:0000250|UniProtKB:P62483, ECO:0000269|PubMed:11825900, ECO:0000269|PubMed:7649300}.		NADPH oxidation [GO:0070995]; regulation of action potential [GO:0098900]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of protein localization to cell surface [GO:2000008]	cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; pinceau fiber [GO:1990031]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; synapse [GO:0045202]; tertiary granule membrane [GO:0070821]; voltage-gated potassium channel complex [GO:0008076]	aldo-keto reductase (NADP) activity [GO:0004033]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; pinceau fiber [GO:1990031]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; synapse [GO:0045202]; tertiary granule membrane [GO:0070821]; voltage-gated potassium channel complex [GO:0008076]; aldo-keto reductase (NADP) activity [GO:0004033]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; NADPH oxidation [GO:0070995]; regulation of action potential [GO:0098900]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of protein localization to cell surface [GO:2000008]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62483}. Membrane {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:21357749}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P62483}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:11086297}. Synapse, synaptosome {ECO:0000269|PubMed:21357749}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P62483}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated. {ECO:0000250|UniProtKB:P62483}.
Q13304	reviewed	GPR17_HUMAN	Uracil nucleotide/cysteinyl leukotriene receptor (UDP/CysLT receptor) (G-protein coupled receptor 17) (P2Y-like receptor) (R12)	GPR17	Homo sapiens (Human)	367	FUNCTION: Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. {ECO:0000269|PubMed:16990797}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; oligodendrocyte differentiation [GO:0048709]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	plasma membrane [GO:0005886]	chemokine receptor activity [GO:0004950]; G protein-coupled receptor activity [GO:0004930]; receptor serine/threonine kinase binding [GO:0033612]	plasma membrane [GO:0005886]; chemokine receptor activity [GO:0004950]; G protein-coupled receptor activity [GO:0004930]; receptor serine/threonine kinase binding [GO:0033612]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; oligodendrocyte differentiation [GO:0048709]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q13308	reviewed	PTK7_HUMAN	Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)	PTK7 CCK4	Homo sapiens (Human)	1070	FUNCTION: Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269|PubMed:18471990, ECO:0000269|PubMed:20558616, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:21103379, ECO:0000269|PubMed:21132015}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; axis elongation [GO:0003401]; cell migration [GO:0016477]; cellular response to retinoic acid [GO:0071300]; cochlea morphogenesis [GO:0090103]; convergent extension [GO:0060026]; coronary vasculature development [GO:0060976]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; kidney development [GO:0001822]; lung-associated mesenchyme development [GO:0060484]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuron projection development [GO:0010976]; regulation of canonical Wnt signaling pathway [GO:0060828]; signal transduction [GO:0007165]; synapse organization [GO:0050808]; ventricular septum development [GO:0003281]; wound healing [GO:0042060]	axon [GO:0030424]; cell-cell junction [GO:0005911]; focal adhesion [GO:0005925]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]; protein kinase activity [GO:0004672]	axon [GO:0030424]; cell-cell junction [GO:0005911]; focal adhesion [GO:0005925]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]; protein kinase activity [GO:0004672]; actin cytoskeleton organization [GO:0030036]; axis elongation [GO:0003401]; cell migration [GO:0016477]; cellular response to retinoic acid [GO:0071300]; cochlea morphogenesis [GO:0090103]; convergent extension [GO:0060026]; coronary vasculature development [GO:0060976]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; kidney development [GO:0001822]; lung-associated mesenchyme development [GO:0060484]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuron projection development [GO:0010976]; regulation of canonical Wnt signaling pathway [GO:0060828]; signal transduction [GO:0007165]; synapse organization [GO:0050808]; ventricular septum development [GO:0003281]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:20837484}; Single-pass type I membrane protein {ECO:0000269|PubMed:20837484}. Cell junction {ECO:0000269|PubMed:20837484}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.
Q13309	reviewed	SKP2_HUMAN	S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)	SKP2 FBXL1	Homo sapiens (Human)	424	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). {ECO:0000250|UniProtKB:Q9Z0Z3, ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|PubMed:16262255, ECO:0000269|PubMed:16581786, ECO:0000269|PubMed:16951159, ECO:0000269|PubMed:17908926, ECO:0000269|PubMed:17962192, ECO:0000269|PubMed:22770219, ECO:0000269|PubMed:32267835}.; FUNCTION: Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. {ECO:0000269|PubMed:27194766}.		defense response to virus [GO:0051607]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; innate immune response [GO:0045087]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of protein polyubiquitination [GO:1902916]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; identical protein binding [GO:0042802]; defense response to virus [GO:0051607]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; innate immune response [GO:0045087]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of protein polyubiquitination [GO:1902916]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22770219}. Nucleus {ECO:0000269|PubMed:22770219}.
Q13310	reviewed	PABP4_HUMAN	Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)	PABPC4 APP1 PABP4	Homo sapiens (Human)	644	FUNCTION: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250}.		blood coagulation [GO:0007596]; myeloid cell development [GO:0061515]; regulation of mRNA stability [GO:0043488]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; blood coagulation [GO:0007596]; myeloid cell development [GO:0061515]; regulation of mRNA stability [GO:0043488]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Q13315	reviewed	ATM_HUMAN	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)	ATM	Homo sapiens (Human)	3056	FUNCTION: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:9733514, PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15456891, PubMed:15448695, PubMed:15916964, PubMed:17923702). Recognizes the substrate consensus sequence [ST]-Q (PubMed:9733514, PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15456891, PubMed:15448695, PubMed:15916964, PubMed:17923702). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:9843217, PubMed:9733515, PubMed:10550055, PubMed:10766245, PubMed:10839545, PubMed:10910365, PubMed:10802669, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:30612738, PubMed:30886146, PubMed:26774286). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}.		brain development [GO:0007420]; cellular response to gamma radiation [GO:0071480]; cellular response to nitrosative stress [GO:0071500]; cellular response to reactive oxygen species [GO:0034614]; cellular response to retinoic acid [GO:0071300]; cellular response to X-ray [GO:0071481]; cellular senescence [GO:0090398]; determination of adult lifespan [GO:0008340]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of protein-containing complex localization to telomere [GO:0097695]; establishment of RNA localization to telomere [GO:0097694]; female meiotic nuclear division [GO:0007143]; heart development [GO:0007507]; histone mRNA catabolic process [GO:0071044]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lipoprotein catabolic process [GO:0042159]; male meiotic nuclear division [GO:0007140]; meiotic telomere clustering [GO:0045141]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic spindle assembly checkpoint signaling [GO:0007094]; multicellular organism growth [GO:0035264]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of telomere capping [GO:1904354]; negative regulation of TORC1 signaling [GO:1904262]; neuron apoptotic process [GO:0051402]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; pexophagy [GO:0000425]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA catabolic process [GO:1903626]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; pre-B cell allelic exclusion [GO:0002331]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; reciprocal meiotic recombination [GO:0007131]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of cell cycle [GO:0051726]; regulation of cellular response to heat [GO:1900034]; regulation of microglial cell activation [GO:1903978]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of telomere maintenance via telomerase [GO:0032210]; replicative senescence [GO:0090399]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; somitogenesis [GO:0001756]; telomere maintenance [GO:0000723]; thymus development [GO:0048538]; V(D)J recombination [GO:0033151]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; spindle [GO:0005819]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent protein kinase activity [GO:0004677]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; spindle [GO:0005819]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent protein kinase activity [GO:0004677]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; brain development [GO:0007420]; cellular response to gamma radiation [GO:0071480]; cellular response to nitrosative stress [GO:0071500]; cellular response to reactive oxygen species [GO:0034614]; cellular response to retinoic acid [GO:0071300]; cellular response to X-ray [GO:0071481]; cellular senescence [GO:0090398]; determination of adult lifespan [GO:0008340]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of protein-containing complex localization to telomere [GO:0097695]; establishment of RNA localization to telomere [GO:0097694]; female meiotic nuclear division [GO:0007143]; heart development [GO:0007507]; histone mRNA catabolic process [GO:0071044]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lipoprotein catabolic process [GO:0042159]; male meiotic nuclear division [GO:0007140]; meiotic telomere clustering [GO:0045141]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic spindle assembly checkpoint signaling [GO:0007094]; multicellular organism growth [GO:0035264]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of telomere capping [GO:1904354]; negative regulation of TORC1 signaling [GO:1904262]; neuron apoptotic process [GO:0051402]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; pexophagy [GO:0000425]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA catabolic process [GO:1903626]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; pre-B cell allelic exclusion [GO:0002331]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; reciprocal meiotic recombination [GO:0007131]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of cell cycle [GO:0051726]; regulation of cellular response to heat [GO:1900034]; regulation of microglial cell activation [GO:1903978]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of telomere maintenance via telomerase [GO:0032210]; replicative senescence [GO:0090399]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; somitogenesis [GO:0001756]; telomere maintenance [GO:0000723]; thymus development [GO:0048538]; V(D)J recombination [GO:0033151]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9050866, ECO:0000269|PubMed:9150358}. Cytoplasmic vesicle {ECO:0000269|PubMed:9050866, ECO:0000269|PubMed:9150358}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q62388}. Peroxisome matrix {ECO:0000269|PubMed:26344566}. Note=Primarily nuclear (PubMed:9050866, PubMed:9150358). Found also in endocytic vesicles in association with beta-adaptin (PubMed:9707615). Translocated to peroxisomes in response to reactive oxygen species (ROS) by PEX5 (PubMed:26344566). {ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:9050866, ECO:0000269|PubMed:9150358, ECO:0000269|PubMed:9707615}.
Q13316	reviewed	DMP1_HUMAN	Dentin matrix acidic phosphoprotein 1 (DMP-1) (Dentin matrix protein 1)	DMP1	Homo sapiens (Human)	513	FUNCTION: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. {ECO:0000269|PubMed:12615915}.		biomineral tissue development [GO:0031214]; extracellular matrix organization [GO:0030198]; ossification [GO:0001503]; positive regulation of cell-substrate adhesion [GO:0010811]; regulation of enamel mineralization [GO:0070173]	endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; integrin binding [GO:0005178]; ion binding [GO:0043167]	endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; integrin binding [GO:0005178]; ion binding [GO:0043167]; biomineral tissue development [GO:0031214]; extracellular matrix organization [GO:0030198]; ossification [GO:0001503]; positive regulation of cell-substrate adhesion [GO:0010811]; regulation of enamel mineralization [GO:0070173]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12615915}. Cytoplasm {ECO:0000269|PubMed:12615915}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12615915}. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.
Q13319	reviewed	CD5R2_HUMAN	Cyclin-dependent kinase 5 activator 2 (CDK5 activator 2) (Cyclin-dependent kinase 5 regulatory subunit 2) (p39) (p39I)	CDK5R2 NCK5AI	Homo sapiens (Human)	367	FUNCTION: Activator of CDK5/TPKII.		axon guidance [GO:0007411]; brain development [GO:0007420]; cerebellum development [GO:0021549]; hippocampus development [GO:0021766]; layer formation in cerebral cortex [GO:0021819]; neuron migration [GO:0001764]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; superior olivary nucleus maturation [GO:0021722]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; protein kinase 5 complex [GO:0016533]	actin binding [GO:0003779]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; protein kinase 5 complex [GO:0016533]; actin binding [GO:0003779]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]; axon guidance [GO:0007411]; brain development [GO:0007420]; cerebellum development [GO:0021549]; hippocampus development [GO:0021766]; layer formation in cerebral cortex [GO:0021819]; neuron migration [GO:0001764]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; superior olivary nucleus maturation [GO:0021722]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18507738}; Lipid-anchor {ECO:0000269|PubMed:18507738}; Cytoplasmic side {ECO:0000269|PubMed:18507738}.
Q13322	reviewed	GRB10_HUMAN	Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)	GRB10 GRBIR KIAA0207	Homo sapiens (Human)	594	FUNCTION: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}.	MISCELLANEOUS: The GRB10 locus is imprinted. During embryonic development, the expression in the brain and spinal cord is from the paternal allele, while in placental villous trophoblasts and skeletal muscle, it is from the maternal one. Expression is biallelic in most other tissues. Paternal expression in the brain is maintained throughout adulthood. Imprinting often is isoform-specific.; MISCELLANEOUS: GRB10 is unlikely to be responsible for Silver-Russell syndrome (SRS).	ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of glucose import [GO:0046325]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of phosphorylation [GO:0042326]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of phosphorylation [GO:0042327]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; response to insulin [GO:0032868]; vascular associated smooth muscle cell migration [GO:1904738]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; signaling receptor complex adaptor activity [GO:0030159]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; signaling receptor complex adaptor activity [GO:0030159]; ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of glucose import [GO:0046325]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of phosphorylation [GO:0042326]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of phosphorylation [GO:0042327]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; response to insulin [GO:0032868]; vascular associated smooth muscle cell migration [GO:1904738]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). {ECO:0000250}.
Q13323	reviewed	BIK_HUMAN	Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4)	BIK NBK	Homo sapiens (Human)	160	FUNCTION: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. {ECO:0000269|PubMed:8521816}.		apoptotic mitochondrial changes [GO:0008637]; apoptotic process [GO:0006915]; male gonad development [GO:0008584]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; regulation of apoptotic process [GO:0042981]	Bcl-2 family protein complex [GO:0097136]; endomembrane system [GO:0012505]; mitochondrial membrane [GO:0031966]		Bcl-2 family protein complex [GO:0097136]; endomembrane system [GO:0012505]; mitochondrial membrane [GO:0031966]; apoptotic mitochondrial changes [GO:0008637]; apoptotic process [GO:0006915]; male gonad development [GO:0008584]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Endomembrane system; Single-pass membrane protein. Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Around the nuclear envelope, and in cytoplasmic membranes.
Q13324	reviewed	CRFR2_HUMAN	Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2)	CRHR2 CRF2R CRH2R	Homo sapiens (Human)	411	FUNCTION: G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; long-term synaptic potentiation [GO:0060291]	axon terminus [GO:0043679]; dendrite [GO:0030425]; plasma membrane [GO:0005886]	corticotrophin-releasing factor receptor activity [GO:0015056]; G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]	axon terminus [GO:0043679]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; corticotrophin-releasing factor receptor activity [GO:0015056]; G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; long-term synaptic potentiation [GO:0060291]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22689579}; Multi-pass membrane protein {ECO:0000269|PubMed:22689579}.
Q13325	reviewed	IFIT5_HUMAN	Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58)	IFIT5 ISG58 RI58	Homo sapiens (Human)	482	FUNCTION: Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375). {ECO:0000269|PubMed:23317505, ECO:0000269|PubMed:23334420, ECO:0000269|PubMed:23774268, ECO:0000269|PubMed:25092312, ECO:0000269|PubMed:26334375}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	actin cytoskeleton [GO:0015629]; apical part of cell [GO:0045177]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	double-stranded DNA binding [GO:0003690]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; single-stranded RNA binding [GO:0003727]; tRNA binding [GO:0000049]	actin cytoskeleton [GO:0015629]; apical part of cell [GO:0045177]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; double-stranded DNA binding [GO:0003690]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; single-stranded RNA binding [GO:0003727]; tRNA binding [GO:0000049]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Cell projection, ruffle membrane {ECO:0000269|PubMed:23317505}. Note=Colocalized with RIGI at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.
Q13326	reviewed	SGCG_HUMAN	Gamma-sarcoglycan (Gamma-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)	SGCG	Homo sapiens (Human)	291	FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.		cardiac muscle tissue development [GO:0048738]; gene expression [GO:0010467]; heart contraction [GO:0060047]; muscle organ development [GO:0007517]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]; cardiac muscle tissue development [GO:0048738]; gene expression [GO:0010467]; heart contraction [GO:0060047]; muscle organ development [GO:0007517]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Q13330	reviewed	MTA1_HUMAN	Metastasis-associated protein MTA1	MTA1	Homo sapiens (Human)	715	FUNCTION: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:21965678, PubMed:17671180, PubMed:16617102). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}.		chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; double-strand break repair [GO:0006302]; entrainment of circadian clock by photoperiod [GO:0043153]; locomotor rhythm [GO:0045475]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein autoubiquitination [GO:1902499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; response to ionizing radiation [GO:0010212]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]	chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; double-strand break repair [GO:0006302]; entrainment of circadian clock by photoperiod [GO:0043153]; locomotor rhythm [GO:0045475]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein autoubiquitination [GO:1902499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; response to ionizing radiation [GO:0010212]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}.; SUBCELLULAR LOCATION: [Isoform Short]: Cytoplasm {ECO:0000269|PubMed:12167865, ECO:0000269|PubMed:15077195}.; SUBCELLULAR LOCATION: [Isoform Long]: Nucleus {ECO:0000269|PubMed:21965678}. Nucleus envelope {ECO:0000269|PubMed:24970816}. Cytoplasm {ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:24970816}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24970816}. Note=Associated with microtubules (PubMed:24970816). Localization at the nuclear envelope is TPR-dependent (PubMed:24970816). {ECO:0000269|PubMed:24970816}.
Q13332	reviewed	PTPRS_HUMAN	Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)	PTPRS	Homo sapiens (Human)	1948	FUNCTION: Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120). {ECO:0000250|UniProtKB:B0V2N1, ECO:0000250|UniProtKB:F1NWE3, ECO:0000269|PubMed:21454754, ECO:0000269|PubMed:26231120, ECO:0000269|PubMed:8524829}.		cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; establishment of endothelial intestinal barrier [GO:0090557]; hippocampus development [GO:0021766]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of axon extension [GO:0030517]; negative regulation of axon regeneration [GO:0048681]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of neuron projection development [GO:0010977]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of postsynaptic density assembly [GO:0099151]; spinal cord development [GO:0021510]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling [GO:0099537]	axon [GO:0030424]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle membrane [GO:0030672]	chondroitin sulfate binding [GO:0035374]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]	axon [GO:0030424]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle membrane [GO:0030672]; chondroitin sulfate binding [GO:0035374]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; establishment of endothelial intestinal barrier [GO:0090557]; hippocampus development [GO:0021766]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of axon extension [GO:0030517]; negative regulation of axon regeneration [GO:0048681]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of neuron projection development [GO:0010977]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of postsynaptic density assembly [GO:0099151]; spinal cord development [GO:0021510]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling [GO:0099537]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26231120}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:B0V2N1}. Perikaryon {ECO:0000250|UniProtKB:B0V2N1}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q64605}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q64605}. Postsynaptic density {ECO:0000250|UniProtKB:Q64605}. Cell projection, neuron projection {ECO:0000250|UniProtKB:B0V2N1}. Cell projection, growth cone {ECO:0000250|UniProtKB:B0V2N1}. Note=Is rapidly internalized when dendritic cells are stimulated with the TLR9 ligand cytidine-phosphate-guanosine (CpG) (PubMed:26231120). Detected in a punctate pattern along neurites and axon growth cones (By similarity). {ECO:0000250|UniProtKB:B0V2N1, ECO:0000269|PubMed:26231120}.
Q13336	reviewed	UT1_HUMAN	Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)	SLC14A1 HUT11 JK RACH1 UT1 UTE	Homo sapiens (Human)	389	FUNCTION: Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes (PubMed:7989337, PubMed:10514515, PubMed:7797558, PubMed:8997401). Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VHL0, ECO:0000269|PubMed:10514515, ECO:0000269|PubMed:7797558, ECO:0000269|PubMed:7989337, ECO:0000269|PubMed:8997401}.		establishment of localization in cell [GO:0051649]; transmembrane transport [GO:0055085]; urea transmembrane transport [GO:0071918]; urea transport [GO:0015840]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	urea channel activity [GO:0015265]; urea transmembrane transporter activity [GO:0015204]; water transmembrane transporter activity [GO:0005372]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; urea channel activity [GO:0015265]; urea transmembrane transporter activity [GO:0015204]; water transmembrane transporter activity [GO:0005372]; establishment of localization in cell [GO:0051649]; transmembrane transport [GO:0055085]; urea transmembrane transport [GO:0071918]; urea transport [GO:0015840]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10514515, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:7797558}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8VHL0}; Multi-pass membrane protein {ECO:0000255}. Note=Restricted to the basolateral membrane in various portions of the urothelium. {ECO:0000250|UniProtKB:Q8VHL0}.
Q13342	reviewed	SP140_HUMAN	Nuclear body protein SP140 (Lymphoid-restricted homolog of Sp100) (LYSp100) (Nuclear autoantigen Sp-140) (Speckled 140 kDa)	SP140 LYSP100	Homo sapiens (Human)	867	FUNCTION: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382). {ECO:0000269|PubMed:24267382, ECO:0000269|PubMed:8910577, ECO:0000303|PubMed:8910577}.	MISCELLANEOUS: This antigen is recognized by autoantibodies from patients with primary biliary cirrhosis. {ECO:0000269|PubMed:8910577}.	defense response [GO:0006952]; regulation of transcription by RNA polymerase II [GO:0006357]	fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; PML body [GO:0016605]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; PML body [GO:0016605]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; defense response [GO:0006952]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}. Nucleus, PML body {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}. Cytoplasm {ECO:0000269|PubMed:8695863}. Note=Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus (PubMed:8695863). Also colocalizes with PML in a subset of PML nuclear bodies (PubMed:8910577). {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}.
Q13347	reviewed	EIF3I_HUMAN	Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36)	EIF3I EIF3S2 TRIP1	Homo sapiens (Human)	325	FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03008, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.		cytoplasmic translational initiation [GO:0002183]; formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; synapse [GO:0045202]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; synapse [GO:0045202]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; cytoplasmic translational initiation [GO:0002183]; formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
Q13349	reviewed	ITAD_HUMAN	Integrin alpha-D (ADB2) (CD11 antigen-like family member D) (Leukointegrin alpha D) (CD antigen CD11d)	ITGAD	Homo sapiens (Human)	1161	FUNCTION: Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.		cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]; metal ion binding [GO:0046872]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q13351	reviewed	KLF1_HUMAN	Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF)	KLF1 EKLF	Homo sapiens (Human)	362	FUNCTION: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation. {ECO:0000250|UniProtKB:P46099, ECO:0000269|PubMed:25585695}.		cellular response to peptide [GO:1901653]; erythrocyte differentiation [GO:0030218]; maternal process involved in female pregnancy [GO:0060135]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; cellular response to peptide [GO:1901653]; erythrocyte differentiation [GO:0030218]; maternal process involved in female pregnancy [GO:0060135]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21055716, ECO:0000269|PubMed:25585695}. Note=Colocalizes with SUMO1 in nuclear speckles. {ECO:0000250}.
Q13352	reviewed	CENPR_HUMAN	Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3)	ITGB3BP CENPR NRIF3	Homo sapiens (Human)	177	FUNCTION: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:11713274, ECO:0000269|PubMed:12244126, ECO:0000269|PubMed:15082778, ECO:0000269|PubMed:15254226, ECO:0000269|PubMed:16622420}.		apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell division [GO:0051301]; CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell division [GO:0051301]; CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
Q13356	reviewed	PPIL2_HUMAN	RING-type E3 ubiquitin-protein ligase PPIL2 (EC 2.3.2.27) (CYC4) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Cyp60) (hCyP-60) (Probable inactive peptidyl-prolyl cis-trans isomerase-like 2) (PPIase) (Rotamase PPIL2)	PPIL2	Homo sapiens (Human)	520	FUNCTION: Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:15946952, ECO:0000269|PubMed:20676357, ECO:0000305|PubMed:33509932}.		mRNA processing [GO:0006397]; protein folding [GO:0006457]; protein localization to plasma membrane [GO:0072659]; protein polyubiquitination [GO:0000209]; RNA splicing [GO:0008380]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; Golgi lumen [GO:0005796]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; Golgi lumen [GO:0005796]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; mRNA processing [GO:0006397]; protein folding [GO:0006457]; protein localization to plasma membrane [GO:0072659]; protein polyubiquitination [GO:0000209]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:8660300}. Note=May also localize to the cytoplasm and the cell membrane. {ECO:0000269|PubMed:15946952}.
Q13360	reviewed	ZN177_HUMAN	Zinc finger protein 177	ZNF177	Homo sapiens (Human)	481	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	blood microparticle [GO:0072562]; nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	blood microparticle [GO:0072562]; nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q13361	reviewed	MFAP5_HUMAN	Microfibrillar-associated protein 5 (MFAP-5) (MP25) (Microfibril-associated glycoprotein 2) (MAGP-2)	MFAP5 MAGP2	Homo sapiens (Human)	173	FUNCTION: May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (PubMed:8557636). {ECO:0000250|UniProtKB:Q9QZJ6, ECO:0000269|PubMed:8557636}.		definitive hemopoiesis [GO:0060216]; embryonic eye morphogenesis [GO:0048048]; supramolecular fiber organization [GO:0097435]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; microfibril [GO:0001527]	extracellular matrix structural constituent [GO:0005201]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; microfibril [GO:0001527]; extracellular matrix structural constituent [GO:0005201]; definitive hemopoiesis [GO:0060216]; embryonic eye morphogenesis [GO:0048048]; supramolecular fiber organization [GO:0097435]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q13362	reviewed	2A5G_HUMAN	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29)	PPP2R5C KIAA0044	Homo sapiens (Human)	524	FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. {ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}.		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of cell population proliferation [GO:0008285]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; signal transduction [GO:0007165]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of cell population proliferation [GO:0008285]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere.
Q13363	reviewed	CTBP1_HUMAN	C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)	CTBP1 CTBP	Homo sapiens (Human)	440	FUNCTION: Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. {ECO:0000269|PubMed:12419229, ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}.		negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle endocytosis [GO:0048488]; viral genome replication [GO:0019079]; white fat cell differentiation [GO:0050872]	GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynaptic active zone cytoplasmic component [GO:0098831]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein domain specific binding [GO:0019904]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]	GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynaptic active zone cytoplasmic component [GO:0098831]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein domain specific binding [GO:0019904]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle endocytosis [GO:0048488]; viral genome replication [GO:0019079]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12679040}. Nucleus {ECO:0000269|PubMed:12679040}.
Q13367	reviewed	AP3B2_HUMAN	AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP)	AP3B2	Homo sapiens (Human)	1082	FUNCTION: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.		anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]	AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin-coated vesicle membrane [GO:0030665]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; presynapse [GO:0098793]		AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin-coated vesicle membrane [GO:0030665]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; presynapse [GO:0098793]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Q13368	reviewed	MPP3_HUMAN	MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3)	MPP3 DLG3	Homo sapiens (Human)	585	FUNCTION: Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K) (PubMed:24503895). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions (By similarity). {ECO:0000250|UniProtKB:O88910, ECO:0000269|PubMed:24503895}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]	PDZ domain binding [GO:0030165]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; PDZ domain binding [GO:0030165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24503895}. Apical cell membrane {ECO:0000269|PubMed:16519681}. Cell junction, adherens junction {ECO:0000269|PubMed:16519681}. Note=Localized in apical villi of Mueller glia cells (By similarity). Localized at the apical membrane in the developing cortex and colocalized with apical proteins and adherens junction proteins (By similarity). Localized at the outer limiting membrane (OLM), and outer plexiform (OPL) of retina (PubMed:16519681). {ECO:0000250|UniProtKB:O88910, ECO:0000269|PubMed:16519681}.
Q13370	reviewed	PDE3B_HUMAN	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B)	PDE3B	Homo sapiens (Human)	1112	FUNCTION: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}.		angiogenesis [GO:0001525]; cellular response to insulin stimulus [GO:0032869]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of lipid catabolic process [GO:0050995]; regulation of angiogenesis [GO:0045765]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; signal transduction [GO:0007165]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; guanyl-nucleotide exchange factor complex [GO:0032045]; membrane [GO:0016020]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; metal ion binding [GO:0046872]; protein kinase B binding [GO:0043422]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; guanyl-nucleotide exchange factor complex [GO:0032045]; membrane [GO:0016020]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; metal ion binding [GO:0046872]; protein kinase B binding [GO:0043422]; angiogenesis [GO:0001525]; cellular response to insulin stimulus [GO:0032869]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of lipid catabolic process [GO:0050995]; regulation of angiogenesis [GO:0045765]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q61409}; Multi-pass membrane protein {ECO:0000255}.
Q13371	reviewed	PHLP_HUMAN	Phosducin-like protein (PHLP)	PDCL PHLOP1 PhLP1	Homo sapiens (Human)	301	FUNCTION: Acts as a positive regulator of hedgehog signaling and regulates ciliary function. {ECO:0000250|UniProtKB:Q9DBX2}.; FUNCTION: [Isoform 1]: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.; FUNCTION: [Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.	MISCELLANEOUS: [Isoform 2]: Expressed ubiquitously, highest levels are found in neural tissues amounting to 10% of total PDCL mRNA. {ECO:0000305}.	cell projection organization [GO:0030030]; heterotrimeric G-protein complex assembly [GO:1902605]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; signal transduction [GO:0007165]; visual perception [GO:0007601]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]		cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cell projection organization [GO:0030030]; heterotrimeric G-protein complex assembly [GO:1902605]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q9DBX2}.
Q13387	reviewed	JIP2_HUMAN	C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)	MAPK8IP2 IB2 JIP2 PRKM8IPL	Homo sapiens (Human)	824	FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 3]: Might be artifactual as it is only predicted from a genomic sequence. {ECO:0000305}.	behavioral fear response [GO:0001662]; dendrite morphogenesis [GO:0048813]; excitatory postsynaptic potential [GO:0060079]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; mating behavior [GO:0007617]; negative regulation of apoptotic signaling pathway [GO:2001234]; nonassociative learning [GO:0046958]; positive regulation of stress-activated MAPK cascade [GO:0032874]; regulation of AMPA receptor activity [GO:2000311]; regulation of JNK cascade [GO:0046328]; regulation of NMDA receptor activity [GO:2000310]; regulation of signaling receptor activity [GO:0010469]; regulation of synaptic transmission, glutamatergic [GO:0051966]; signal complex assembly [GO:0007172]; social behavior [GO:0035176]	cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]	amyloid-beta binding [GO:0001540]; JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; amyloid-beta binding [GO:0001540]; JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]; behavioral fear response [GO:0001662]; dendrite morphogenesis [GO:0048813]; excitatory postsynaptic potential [GO:0060079]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; mating behavior [GO:0007617]; negative regulation of apoptotic signaling pathway [GO:2001234]; nonassociative learning [GO:0046958]; positive regulation of stress-activated MAPK cascade [GO:0032874]; regulation of AMPA receptor activity [GO:2000311]; regulation of JNK cascade [GO:0046328]; regulation of NMDA receptor activity [GO:2000310]; regulation of signaling receptor activity [GO:0010469]; regulation of synaptic transmission, glutamatergic [GO:0051966]; signal complex assembly [GO:0007172]; social behavior [GO:0035176]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10490659}. Note=Accumulates in cell surface projections. {ECO:0000269|PubMed:10490659}.
Q13393	reviewed	PLD1_HUMAN	Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1)	PLD1	Homo sapiens (Human)	1074	FUNCTION: Function as phospholipase selective for phosphatidylcholine (PubMed:8530346, PubMed:9582313, PubMed:25936805). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}.		cellular response to nutrient [GO:0031670]; chemotaxis [GO:0006935]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid catabolic process [GO:0009395]; positive regulation of translation [GO:0045727]; Ras protein signal transduction [GO:0007265]; regulation of microvillus assembly [GO:0032534]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of vesicle-mediated transport [GO:0060627]; small GTPase mediated signal transduction [GO:0007264]	apical plasma membrane [GO:0016324]; cholinergic synapse [GO:0098981]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; phosphatidylinositol binding [GO:0035091]; phospholipase D activity [GO:0004630]	apical plasma membrane [GO:0016324]; cholinergic synapse [GO:0098981]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; phosphatidylinositol binding [GO:0035091]; phospholipase D activity [GO:0004630]; cellular response to nutrient [GO:0031670]; chemotaxis [GO:0006935]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid catabolic process [GO:0009395]; positive regulation of translation [GO:0045727]; Ras protein signal transduction [GO:0007265]; regulation of microvillus assembly [GO:0032534]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of vesicle-mediated transport [GO:0060627]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9Z280}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z280}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z280}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z280}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Z280}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z280}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z280}. Late endosome membrane {ECO:0000250|UniProtKB:Q9Z280}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z280}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z280}.
Q13394	reviewed	MB211_HUMAN	Putative nucleotidyltransferase MAB21L1 (EC 2.7.7.-) (Protein mab-21-like 1)	MAB21L1 CAGR1 Nbla00126	Homo sapiens (Human)	359	FUNCTION: Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (PubMed:27103078, PubMed:30487245). It is unclear whether it displays nucleotidyltransferase activity in vivo (PubMed:27271801). Binds single-stranded RNA (ssRNA) (PubMed:27271801). {ECO:0000269|PubMed:27103078, ECO:0000269|PubMed:27271801, ECO:0000269|PubMed:30487245}.		anatomical structure morphogenesis [GO:0009653]; camera-type eye development [GO:0043010]; cell population proliferation [GO:0008283]; eye development [GO:0001654]; positive regulation of cell population proliferation [GO:0008284]	nucleus [GO:0005634]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; nucleotidyltransferase activity [GO:0016779]	nucleus [GO:0005634]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; nucleotidyltransferase activity [GO:0016779]; anatomical structure morphogenesis [GO:0009653]; camera-type eye development [GO:0043010]; cell population proliferation [GO:0008283]; eye development [GO:0001654]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O70299}.
Q13395	reviewed	TARB1_HUMAN	Probable methyltransferase TARBP1 (EC 2.1.1.-) (TAR RNA-binding protein 1) (TAR RNA-binding protein of 185 kDa) (TRP-185)	TARBP1 TRM3 TRP185	Homo sapiens (Human)	1621	FUNCTION: Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. {ECO:0000305|PubMed:18412263}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II (PubMed:7638159, PubMed:8626763, PubMed:8846792). Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA (PubMed:7638159, PubMed:8626763, PubMed:8846792). {ECO:0000269|PubMed:7638159, ECO:0000269|PubMed:8626763, ECO:0000269|PubMed:8846792}.		regulation of transcription by RNA polymerase II [GO:0006357]; tRNA methylation [GO:0030488]	nucleus [GO:0005634]	RNA binding [GO:0003723]; tRNA (guanine) methyltransferase activity [GO:0016423]	nucleus [GO:0005634]; RNA binding [GO:0003723]; tRNA (guanine) methyltransferase activity [GO:0016423]; regulation of transcription by RNA polymerase II [GO:0006357]; tRNA methylation [GO:0030488]	
Q13398	reviewed	ZN211_HUMAN	Zinc finger protein 211 (Zinc finger protein C2H2-25)	ZNF211	Homo sapiens (Human)	564	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q13402	reviewed	MYO7A_HUMAN	Unconventional myosin-VIIa	MYO7A USH1B	Homo sapiens (Human)	2215	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. {ECO:0000250, ECO:0000269|PubMed:19643958, ECO:0000269|PubMed:21493626, ECO:0000269|PubMed:21687988, ECO:0000269|PubMed:21709241}.		actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; auditory receptor cell stereocilium organization [GO:0060088]; equilibrioception [GO:0050957]; eye photoreceptor cell development [GO:0042462]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; mechanoreceptor differentiation [GO:0042490]; phagolysosome assembly [GO:0001845]; pigment granule transport [GO:0051904]; post-embryonic animal organ morphogenesis [GO:0048563]; protein localization [GO:0008104]; sensory organ development [GO:0007423]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; vesicle transport along actin filament [GO:0030050]; visual perception [GO:0007601]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; microvillus [GO:0005902]; myosin VII complex [GO:0031477]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; stereocilium [GO:0032420]; stereocilium base [GO:0120044]; synapse [GO:0045202]; upper tip-link density [GO:1990435]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904]; spectrin binding [GO:0030507]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; microvillus [GO:0005902]; myosin VII complex [GO:0031477]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; stereocilium [GO:0032420]; stereocilium base [GO:0120044]; synapse [GO:0045202]; upper tip-link density [GO:1990435]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904]; spectrin binding [GO:0030507]; actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; auditory receptor cell stereocilium organization [GO:0060088]; equilibrioception [GO:0050957]; eye photoreceptor cell development [GO:0042462]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; mechanoreceptor differentiation [GO:0042490]; phagolysosome assembly [GO:0001845]; pigment granule transport [GO:0051904]; post-embryonic animal organ morphogenesis [GO:0048563]; protein localization [GO:0008104]; sensory organ development [GO:0007423]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; vesicle transport along actin filament [GO:0030050]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P97479}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P97479}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P97479}. Synapse {ECO:0000269|PubMed:8842737}. Note=In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region (PubMed:8842737). In retinal pigment epithelial cells colocalizes with a subset of melanosomes, displays predominant localization to stress fiber-like structures and some localization to cytoplasmic puncta (PubMed:19643958, PubMed:27331610). Detected at the tip of cochlear hair cell stereocilia (PubMed:21709241). The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin (PubMed:21709241). {ECO:0000269|PubMed:19643958, ECO:0000269|PubMed:21709241, ECO:0000269|PubMed:27331610, ECO:0000269|PubMed:8842737}.
Q13404	reviewed	UB2V1_HUMAN	Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A)	UBE2V1 CROC1 UBE2V UEV1 P/OKcl.19	Homo sapiens (Human)	147	FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. {ECO:0000269|PubMed:11057907, ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:31006531, ECO:0000269|PubMed:9305758, ECO:0000269|PubMed:9418904, ECO:0000269|PubMed:9580084, ECO:0000269|PubMed:9705497}.	MISCELLANEOUS: In human, PESD1/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a PESD1-UBE2V1 hybrid protein.	cell differentiation [GO:0030154]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; postreplication repair [GO:0006301]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; UBC13-UEV1A complex [GO:0035370]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; UBC13-UEV1A complex [GO:0035370]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151]; cell differentiation [GO:0030154]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; postreplication repair [GO:0006301]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11076860, ECO:0000269|PubMed:9305758}. Note=Excluded from the nucleolus.
Q13405	reviewed	RM49_HUMAN	Large ribosomal subunit protein mL49 (39S ribosomal protein L49, mitochondrial) (L49mt) (MRP-L49) (Neighbor of FAU) (NOF) (Protein NOF1)	MRPL49 C11orf4 NOF1 OK/SW-cl.67	Homo sapiens (Human)	166			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q13409	reviewed	DC1I2_HUMAN	Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)	DYNC1I2 DNCI2 DNCIC2	Homo sapiens (Human)	638	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). {ECO:0000250|UniProtKB:Q62871, ECO:0000269|PubMed:31079899}.		microtubule-based movement [GO:0007018]; transport along microtubule [GO:0010970]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynein complex [GO:0030286]; microtubule [GO:0005874]; vesicle [GO:0031982]	dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; microtubule motor activity [GO:0003777]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynein complex [GO:0030286]; microtubule [GO:0005874]; vesicle [GO:0031982]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]; transport along microtubule [GO:0010970]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305|PubMed:36071160}. Cytoplasm {ECO:0000250|UniProtKB:O88487}. Note=Detected in the cytoplasm of pachytene spermatocytes. Localizes to the manchette in elongating spermatids. {ECO:0000250|UniProtKB:O88487}.
Q13410	reviewed	BT1A1_HUMAN	Butyrophilin subfamily 1 member A1 (BT)	BTN1A1 BTN	Homo sapiens (Human)	526	FUNCTION: May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). {ECO:0000250}.		regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Secreted.
Q13415	reviewed	ORC1_HUMAN	Origin recognition complex subunit 1 (Replication control protein 1)	ORC1 ORC1L PARC1	Homo sapiens (Human)	861	FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.		DNA replication initiation [GO:0006270]; mitotic DNA replication checkpoint signaling [GO:0033314]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; DNA replication initiation [GO:0006270]; mitotic DNA replication checkpoint signaling [GO:0033314]	SUBCELLULAR LOCATION: Nucleus.
Q13416	reviewed	ORC2_HUMAN	Origin recognition complex subunit 2	ORC2 ORC2L	Homo sapiens (Human)	577	FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}.		DNA replication initiation [GO:0006270]; negative regulation of transcription by RNA polymerase II [GO:0000122]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; heterochromatin [GO:0000792]; inner kinetochore [GO:0000939]; membrane [GO:0016020]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]	DNA replication origin binding [GO:0003688]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; heterochromatin [GO:0000792]; inner kinetochore [GO:0000939]; membrane [GO:0016020]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]; DNA replication origin binding [GO:0003688]; DNA replication initiation [GO:0006270]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus.
Q13418	reviewed	ILK_HUMAN	Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK)	ILK ILK1 ILK2	Homo sapiens (Human)	452	FUNCTION: Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling (PubMed:10712922). Focal adhesion protein part of the complex ILK-PINCH (PubMed:10712922). This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway (PubMed:10712922). Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells (PubMed:10712922). Regulates cell motility by forming a complex with PARVB (PubMed:32528174). Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715). {ECO:0000269|PubMed:32528174, ECO:0000269|PubMed:8538749, ECO:0000269|PubMed:9736715, ECO:0000303|PubMed:10712922}.		branching involved in ureteric bud morphogenesis [GO:0001658]; cell morphogenesis [GO:0000902]; cell projection organization [GO:0030030]; cell-matrix adhesion [GO:0007160]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; fibroblast migration [GO:0010761]; integrin-mediated signaling pathway [GO:0007229]; myelination in peripheral nervous system [GO:0022011]; negative regulation of neural precursor cell proliferation [GO:2000178]; nerve development [GO:0021675]; neural precursor cell proliferation [GO:0061351]; outflow tract morphogenesis [GO:0003151]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet aggregation [GO:0070527]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of signal transduction [GO:0009967]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein phosphorylation [GO:0006468]; substrate adhesion-dependent cell spreading [GO:0034446]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sarcomere [GO:0030017]	ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sarcomere [GO:0030017]; ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell morphogenesis [GO:0000902]; cell projection organization [GO:0030030]; cell-matrix adhesion [GO:0007160]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; fibroblast migration [GO:0010761]; integrin-mediated signaling pathway [GO:0007229]; myelination in peripheral nervous system [GO:0022011]; negative regulation of neural precursor cell proliferation [GO:2000178]; nerve development [GO:0021675]; neural precursor cell proliferation [GO:0061351]; outflow tract morphogenesis [GO:0003151]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet aggregation [GO:0070527]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of signal transduction [GO:0009967]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein phosphorylation [GO:0006468]; substrate adhesion-dependent cell spreading [GO:0034446]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:12167643}. Cell membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:11402068}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O55222}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:11402068}.
Q13421	reviewed	MSLN_HUMAN	Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form]	MSLN MPF	Homo sapiens (Human)	630	FUNCTION: Membrane-anchored forms may play a role in cellular adhesion.; FUNCTION: Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.	MISCELLANEOUS: [Isoform 1]: Minor form.; MISCELLANEOUS: [Isoform 2]: Major form. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Soluble form found in the sera from patients with ovarian carcinoma. {ECO:0000305}.	cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.; SUBCELLULAR LOCATION: [Megakaryocyte-potentiating factor]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Q13422	reviewed	IKZF1_HUMAN	DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)	IKZF1 IK1 IKAROS LYF1 ZNFN1A1	Homo sapiens (Human)	519	FUNCTION: Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}.		cell cycle [GO:0007049]; chromatin organization [GO:0006325]; erythrocyte differentiation [GO:0030218]; lymphocyte differentiation [GO:0030098]; mesoderm development [GO:0007498]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell cycle [GO:0007049]; chromatin organization [GO:0006325]; erythrocyte differentiation [GO:0030218]; lymphocyte differentiation [GO:0030098]; mesoderm development [GO:0007498]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:21548011, ECO:0000269|PubMed:22106042, ECO:0000269|PubMed:23071339}. Note=In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events. {ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:22106042}.; SUBCELLULAR LOCATION: [Isoform Ik2]: Nucleus. Note=In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform Ik6]: Cytoplasm {ECO:0000250}.
Q13423	reviewed	NNTM_HUMAN	NAD(P) transhydrogenase, mitochondrial (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)	NNT	Homo sapiens (Human)	1086	FUNCTION: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (PubMed:22634753). {ECO:0000250|UniProtKB:P07001, ECO:0000269|PubMed:22634753}.		cell redox homeostasis [GO:0045454]; cellular oxidant detoxification [GO:0098869]; intracellular oxygen homeostasis [GO:0032364]; NADPH regeneration [GO:0006740]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of hydrogen peroxide catabolic process [GO:1903285]; positive regulation of mitochondrial membrane potential [GO:0010918]; proton transmembrane transport [GO:1902600]; reactive oxygen species metabolic process [GO:0072593]; response to vitamin [GO:0033273]; tricarboxylic acid cycle [GO:0006099]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrion [GO:0005739]	NAD binding [GO:0051287]; NAD(P)+ transhydrogenase (B-specific) activity [GO:0003957]; NAD(P)+ transhydrogenase activity [GO:0008746]; NADP binding [GO:0050661]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrion [GO:0005739]; NAD binding [GO:0051287]; NAD(P)+ transhydrogenase (B-specific) activity [GO:0003957]; NAD(P)+ transhydrogenase activity [GO:0008746]; NADP binding [GO:0050661]; cell redox homeostasis [GO:0045454]; cellular oxidant detoxification [GO:0098869]; intracellular oxygen homeostasis [GO:0032364]; NADPH regeneration [GO:0006740]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of hydrogen peroxide catabolic process [GO:1903285]; positive regulation of mitochondrial membrane potential [GO:0010918]; proton transmembrane transport [GO:1902600]; reactive oxygen species metabolic process [GO:0072593]; response to vitamin [GO:0033273]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Q13424	reviewed	SNTA1_HUMAN	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1)	SNTA1 SNT1	Homo sapiens (Human)	505	FUNCTION: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). {ECO:0000250}.		muscle contraction [GO:0006936]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuromuscular junction development [GO:0007528]; regulation of heart rate [GO:0002027]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of vasoconstriction by circulating norepinephrine [GO:0003117]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005]	anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; neuromuscular junction [GO:0031594]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; syntrophin complex [GO:0016013]	actin binding [GO:0003779]; ATPase binding [GO:0051117]; calmodulin binding [GO:0005516]; nitric-oxide synthase binding [GO:0050998]; PDZ domain binding [GO:0030165]; sodium channel regulator activity [GO:0017080]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325]	anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; neuromuscular junction [GO:0031594]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; syntrophin complex [GO:0016013]; actin binding [GO:0003779]; ATPase binding [GO:0051117]; calmodulin binding [GO:0005516]; nitric-oxide synthase binding [GO:0050998]; PDZ domain binding [GO:0030165]; sodium channel regulator activity [GO:0017080]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325]; muscle contraction [GO:0006936]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuromuscular junction development [GO:0007528]; regulation of heart rate [GO:0002027]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of vasoconstriction by circulating norepinephrine [GO:0003117]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions. {ECO:0000250}.
Q13425	reviewed	SNTB2_HUMAN	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL)	SNTB2 D16S2531E SNT2B2 SNTL	Homo sapiens (Human)	540	FUNCTION: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.	MISCELLANEOUS: [Isoform 2]: Lacks domains required for interaction with dystrophin related proteins. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytoplasm [GO:0005737]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658]	actin binding [GO:0003779]; calmodulin binding [GO:0005516]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658]; actin binding [GO:0003779]; calmodulin binding [GO:0005516]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: Membrane. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton. Note=Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules. {ECO:0000250}.
Q13426	reviewed	XRCC4_HUMAN	DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)]	XRCC4	Homo sapiens (Human)	336	FUNCTION: [DNA repair protein XRCC4]: DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination (PubMed:10757784, PubMed:10854421, PubMed:17124166, PubMed:16412978, PubMed:8548796, PubMed:25742519, PubMed:12517771, PubMed:17290226, PubMed:22228831, PubMed:25597996, PubMed:25934149, PubMed:26100018, PubMed:26774286). Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) (PubMed:15385968, PubMed:20852255, PubMed:26774286, PubMed:27437582). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:26100018, PubMed:27437582, PubMed:28500754, PubMed:21775435, PubMed:22287571, PubMed:21768349). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed (PubMed:9242410, PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:19837014). XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity (PubMed:9242410, PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:21982441, PubMed:22228831). Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10757784, PubMed:10854421). Promotes displacement of PNKP from processed strand break termini (PubMed:20852255, PubMed:28453785). {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:17124166, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:19837014, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25742519, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28453785, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:8548796, ECO:0000269|PubMed:9242410}.; FUNCTION: [Protein XRCC4, C-terminus]: Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486). {ECO:0000269|PubMed:33725486}.		DNA ligation involved in DNA repair [GO:0051103]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; positive regulation of ligase activity [GO:0051351]; protein localization to site of double-strand break [GO:1990166]; response to X-ray [GO:0010165]	cytosol [GO:0005829]; DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	FHA domain binding [GO:0070975]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; FHA domain binding [GO:0070975]; identical protein binding [GO:0042802]; DNA ligation involved in DNA repair [GO:0051103]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; positive regulation of ligase activity [GO:0051351]; protein localization to site of double-strand break [GO:1990166]; response to X-ray [GO:0010165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16478998, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:24984242, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:33725486, ECO:0000269|PubMed:9259561}. Chromosome {ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:31548606}. Note=Localizes to site of double-strand breaks. {ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582}.; SUBCELLULAR LOCATION: [Protein XRCC4, C-terminus]: Cytoplasm {ECO:0000269|PubMed:33725486}. Note=Translocates from the nucleus to the cytoplasm following cleavage by caspase-3 (CASP3). {ECO:0000269|PubMed:33725486}.
Q13427	reviewed	PPIG_HUMAN	Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G)	PPIG	Homo sapiens (Human)	754	FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}.		protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:15358154}. Nucleus speckle {ECO:0000269|PubMed:15358154}. Note=Colocalizes with RNA splicing factors at nuclear speckles. {ECO:0000269|PubMed:15358154}.
Q13428	reviewed	TCOF_HUMAN	Treacle protein (Treacher Collins syndrome protein)	TCOF1	Homo sapiens (Human)	1488	FUNCTION: Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.	MISCELLANEOUS: [Isoform 1]: Major.; MISCELLANEOUS: [Isoform 4]: Minor. {ECO:0000305}.	neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; regulation of translation [GO:0006417]; skeletal system development [GO:0001501]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; regulation of translation [GO:0006417]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12777385}.
Q13432	reviewed	U119A_HUMAN	Protein unc-119 homolog A (Retinal protein 4) (hRG4)	UNC119 RG4	Homo sapiens (Human)	240	FUNCTION: Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A. {ECO:0000269|PubMed:12496276, ECO:0000269|PubMed:14757743, ECO:0000269|PubMed:19381274, ECO:0000269|PubMed:21642972, ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:23535298, ECO:0000305|PubMed:22960633}.		chemical synaptic transmission [GO:0007268]; endocytosis [GO:0006897]; lipoprotein transport [GO:0042953]; mitotic cytokinesis [GO:0000281]; negative regulation of caveolin-mediated endocytosis [GO:2001287]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; nervous system development [GO:0007399]; phototransduction [GO:0007602]; positive regulation of protein tyrosine kinase activity [GO:0061098]; visual perception [GO:0007601]	centrosome [GO:0005813]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]; synapse [GO:0045202]	lipid binding [GO:0008289]	centrosome [GO:0005813]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]; synapse [GO:0045202]; lipid binding [GO:0008289]; chemical synaptic transmission [GO:0007268]; endocytosis [GO:0006897]; lipoprotein transport [GO:0042953]; mitotic cytokinesis [GO:0000281]; negative regulation of caveolin-mediated endocytosis [GO:2001287]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; nervous system development [GO:0007399]; phototransduction [GO:0007602]; positive regulation of protein tyrosine kinase activity [GO:0061098]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23535298}. Note=Localizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells. {ECO:0000269|PubMed:23535298}.
Q13433	reviewed	S39A6_HUMAN	Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)	SLC39A6 LIV1 ZIP6	Homo sapiens (Human)	755	FUNCTION: Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:27274087, PubMed:18272141, PubMed:21422171, PubMed:34394081, PubMed:23919497, PubMed:12839489). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (PubMed:27274087). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence (PubMed:23919497). In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (PubMed:30552163, PubMed:21422171, PubMed:34394081). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461). {ECO:0000250|UniProtKB:Q8C145, ECO:0000269|PubMed:12839489, ECO:0000269|PubMed:18272141, ECO:0000269|PubMed:21422171, ECO:0000269|PubMed:23919497, ECO:0000269|PubMed:25143461, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30552163, ECO:0000269|PubMed:32797246, ECO:0000269|PubMed:34394081}.		epithelial to mesenchymal transition [GO:0001837]; intracellular zinc ion homeostasis [GO:0006882]; lymphocyte activation [GO:0046649]; T cell receptor signaling pathway [GO:0050852]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; lamellipodium membrane [GO:0031258]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; lamellipodium membrane [GO:0031258]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]; epithelial to mesenchymal transition [GO:0001837]; intracellular zinc ion homeostasis [GO:0006882]; lymphocyte activation [GO:0046649]; T cell receptor signaling pathway [GO:0050852]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18272141}; Multi-pass membrane protein {ECO:0000255}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:12839489}; Multi-pass membrane protein {ECO:0000269|PubMed:12839489}. Membrane raft {ECO:0000269|PubMed:34394081}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q4V887}. Note=Localizes to lipid rafts in T cells and is recruited into the immunological synapse in response to TCR stimulation (PubMed:34394081). In the choroid plexus is limited to the apical membrane in epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q4V887, ECO:0000269|PubMed:34394081}.
Q13435	reviewed	SF3B2_HUMAN	Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145)	SF3B2 SAP145	Homo sapiens (Human)	895	FUNCTION: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077) (Probable). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000305|PubMed:33509932}.		mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300}. Nucleus speckle {ECO:0000269|PubMed:16923959}.
Q13438	reviewed	OS9_HUMAN	Protein OS-9 (Amplified in osteosarcoma 9)	OS9	Homo sapiens (Human)	667	FUNCTION: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. {ECO:0000269|PubMed:17932042, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18417469, ECO:0000269|PubMed:19084021, ECO:0000269|PubMed:19346256, ECO:0000269|PubMed:21172656}.	MISCELLANEOUS: [Isoform 1]: Major isoform.; MISCELLANEOUS: [Isoform 2]: Major isoform. {ECO:0000305}.	endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein retention in ER lumen [GO:0006621]; protein targeting [GO:0006605]; protein ubiquitination [GO:0016567]; response to endoplasmic reticulum stress [GO:0034976]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase complex [GO:0000836]	carbohydrate binding [GO:0030246]; protease binding [GO:0002020]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase complex [GO:0000836]; carbohydrate binding [GO:0030246]; protease binding [GO:0002020]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein retention in ER lumen [GO:0006621]; protein targeting [GO:0006605]; protein ubiquitination [GO:0016567]; response to endoplasmic reticulum stress [GO:0034976]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18417469, ECO:0000269|PubMed:19084021}.
Q13439	reviewed	GOGA4_HUMAN	Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230)	GOLGA4	Homo sapiens (Human)	2230	FUNCTION: Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}.	MISCELLANEOUS: Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.	Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle transport [GO:0048193]; positive regulation of axon extension [GO:0045773]; vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GTPase binding [GO:0051020]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; GTPase binding [GO:0051020]; small GTPase binding [GO:0031267]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle transport [GO:0048193]; positive regulation of axon extension [GO:0045773]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane {ECO:0000269|PubMed:10209123, ECO:0000269|PubMed:10209125, ECO:0000269|PubMed:11303027, ECO:0000269|PubMed:14718928, ECO:0000269|PubMed:15265687}; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:29084197}.
Q13443	reviewed	ADAM9_HUMAN	Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase)	ADAM9 KIAA0021 MCMP MDC9 MLTNG	Homo sapiens (Human)	819	FUNCTION: Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269|PubMed:12054541}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	amyloid precursor protein catabolic process [GO:0042987]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cellular response to lipopolysaccharide [GO:0071222]; integrin-mediated signaling pathway [GO:0007229]; keratinocyte differentiation [GO:0030216]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; monocyte activation [GO:0042117]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration [GO:0030335]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein secretion [GO:0050714]; protein processing [GO:0016485]; response to antineoplastic agent [GO:0097327]; response to calcium ion [GO:0051592]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to laminar fluid shear stress [GO:0034616]; response to manganese ion [GO:0010042]; response to tumor necrosis factor [GO:0034612]; transforming growth factor beta receptor signaling pathway [GO:0007179]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	collagen binding [GO:0005518]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; protein kinase C binding [GO:0005080]; SH3 domain binding [GO:0017124]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; collagen binding [GO:0005518]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; protein kinase C binding [GO:0005080]; SH3 domain binding [GO:0017124]; amyloid precursor protein catabolic process [GO:0042987]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cellular response to lipopolysaccharide [GO:0071222]; integrin-mediated signaling pathway [GO:0007229]; keratinocyte differentiation [GO:0030216]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; monocyte activation [GO:0042117]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration [GO:0030335]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein secretion [GO:0050714]; protein processing [GO:0016485]; response to antineoplastic agent [GO:0097327]; response to calcium ion [GO:0051592]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to laminar fluid shear stress [GO:0034616]; response to manganese ion [GO:0010042]; response to tumor necrosis factor [GO:0034612]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:8647900}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:12054541}.
Q13444	reviewed	ADA15_HUMAN	Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)	ADAM15 MDC15	Homo sapiens (Human)	863	FUNCTION: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333, ECO:0000269|PubMed:18434311}.		angiogenesis [GO:0001525]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell-matrix adhesion [GO:0007160]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; immune response to tumor cell [GO:0002418]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; male gonad development [GO:0008584]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of receptor binding [GO:1900121]; proteolysis [GO:0006508]; response to hypobaric hypoxia [GO:1990910]; tissue regeneration [GO:0042246]	acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; SH3 domain binding [GO:0017124]	acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; SH3 domain binding [GO:0017124]; angiogenesis [GO:0001525]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell-matrix adhesion [GO:0007160]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; immune response to tumor cell [GO:0002418]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; male gonad development [GO:0008584]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of receptor binding [GO:1900121]; proteolysis [GO:0006508]; response to hypobaric hypoxia [GO:1990910]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:12243749}; Single-pass type I membrane protein {ECO:0000269|PubMed:12243749}. Cell junction, adherens junction {ECO:0000269|PubMed:12243749}. Cell projection, cilium, flagellum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed (By similarity). {ECO:0000250}.
Q13445	reviewed	TMED1_HUMAN	Transmembrane emp24 domain-containing protein 1 (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor-binding protein) (p24 family protein gamma-1) (Tp24) (p24gamma1)	TMED1 IL1RL1L IL1RL1LG	Homo sapiens (Human)	227	FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1 (PubMed:23319592). Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). {ECO:0000269|PubMed:23319592, ECO:0000269|PubMed:32614325}.	MISCELLANEOUS: Found only in very low concentrations in the endoplasmic reticulum, Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment compared to other members of the EMP24/GP25L family.	cell-cell signaling [GO:0007267]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; signal transduction [GO:0007165]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	signaling receptor binding [GO:0005102]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; signaling receptor binding [GO:0005102]; cell-cell signaling [GO:0007267]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:8621446}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:23319592}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}.
Q13449	reviewed	LSAMP_HUMAN	Limbic system-associated membrane protein (LSAMP) (IgLON family member 3)	LSAMP IGLON3 LAMP	Homo sapiens (Human)	338	FUNCTION: Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; nervous system development [GO:0007399]	cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell adhesion [GO:0007155]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
Q13451	reviewed	FKBP5_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)	FKBP5 AIG6 FKBP51	Homo sapiens (Human)	457	FUNCTION: Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production (PubMed:26101251, PubMed:31434731). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:26101251, ECO:0000269|PubMed:28147277, ECO:0000269|PubMed:31434731}.		chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; response to bacterium [GO:0009617]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	FK506 binding [GO:0005528]; heat shock protein binding [GO:0031072]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; FK506 binding [GO:0005528]; heat shock protein binding [GO:0031072]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q64378}. Nucleus {ECO:0000250|UniProtKB:Q64378}.
Q13454	reviewed	TUSC3_HUMAN	Tumor suppressor candidate 3 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3) (Oligosaccharyl transferase subunit TUSC3) (Magnesium uptake/transporter TUSC3) (Protein N33)	TUSC3 N33	Homo sapiens (Human)	348	FUNCTION: Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. {ECO:0000269|PubMed:25135935, ECO:0000305|PubMed:12887896, ECO:0000305|PubMed:24685145}.; FUNCTION: Magnesium transporter. {ECO:0000269|PubMed:19717468}.		cognition [GO:0050890]; magnesium ion transport [GO:0015693]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; transmembrane transport [GO:0055085]	endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]	magnesium ion transmembrane transporter activity [GO:0015095]	endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]; magnesium ion transmembrane transporter activity [GO:0015095]; cognition [GO:0050890]; magnesium ion transport [GO:0015693]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q13459	reviewed	MYO9B_HUMAN	Unconventional myosin-IXb (Unconventional myosin-9b)	MYO9B MYR5	Homo sapiens (Human)	2157	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}.		actin filament-based movement [GO:0030048]; lamellipodium morphogenesis [GO:0072673]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; myosin complex [GO:0016459]; perinuclear region of cytoplasm [GO:0048471]; ruffle [GO:0001726]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146]; Roundabout binding [GO:0048495]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; myosin complex [GO:0016459]; perinuclear region of cytoplasm [GO:0048471]; ruffle [GO:0001726]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146]; Roundabout binding [GO:0048495]; small GTPase binding [GO:0031267]; actin filament-based movement [GO:0030048]; lamellipodium morphogenesis [GO:0072673]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:8907710}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:8907710}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8907710, ECO:0000269|PubMed:9490638}. Note=In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region. {ECO:0000269|PubMed:8907710}.
Q13461	reviewed	FOXE3_HUMAN	Forkhead box protein E3 (Forkhead-related protein FKHL12) (Forkhead-related transcription factor 8) (FREAC-8)	FOXE3 FKHL12 FREAC8	Homo sapiens (Human)	319	FUNCTION: Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (PubMed:27218149). {ECO:0000250|UniProtKB:Q9QY14, ECO:0000269|PubMed:22527307, ECO:0000269|PubMed:25504734, ECO:0000269|PubMed:27218149}.		anatomical structure morphogenesis [GO:0009653]; cell development [GO:0048468]; cell differentiation [GO:0030154]; ciliary body morphogenesis [GO:0061073]; cornea development in camera-type eye [GO:0061303]; epithelial cell proliferation [GO:0050673]; eye development [GO:0001654]; iris morphogenesis [GO:0061072]; lens development in camera-type eye [GO:0002088]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of lens fiber cell differentiation [GO:1902747]; positive regulation of lens epithelial cell proliferation [GO:2001111]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; trabecular meshwork development [GO:0002930]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; anatomical structure morphogenesis [GO:0009653]; cell development [GO:0048468]; cell differentiation [GO:0030154]; ciliary body morphogenesis [GO:0061073]; cornea development in camera-type eye [GO:0061303]; epithelial cell proliferation [GO:0050673]; eye development [GO:0001654]; iris morphogenesis [GO:0061072]; lens development in camera-type eye [GO:0002088]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of lens fiber cell differentiation [GO:1902747]; positive regulation of lens epithelial cell proliferation [GO:2001111]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; trabecular meshwork development [GO:0002930]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25504734}.
Q13464	reviewed	ROCK1_HUMAN	Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)	ROCK1	Homo sapiens (Human)	1354	FUNCTION: Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579, PubMed:23093407, PubMed:23355470). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}.		actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; aortic valve morphogenesis [GO:0003180]; apical constriction [GO:0003383]; bleb assembly [GO:0032060]; blood vessel diameter maintenance [GO:0097746]; canonical NF-kappaB signal transduction [GO:0007249]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; epithelial to mesenchymal transition [GO:0001837]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; mitotic cytokinesis [GO:0000281]; motor neuron apoptotic process [GO:0097049]; mRNA destabilization [GO:0061157]; myoblast migration [GO:0051451]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; negative regulation of phosphorylation [GO:0042326]; negative regulation of protein binding [GO:0032091]; neuron projection arborization [GO:0140058]; neuron projection development [GO:0031175]; peptidyl-serine phosphorylation [GO:0018105]; podocyte cell migration [GO:0090521]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of autophagy [GO:0010508]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatase activity [GO:0010922]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of amyloid-beta formation [GO:1902003]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of autophagy [GO:0010506]; regulation of cell adhesion [GO:0030155]; regulation of cell junction assembly [GO:1901888]; regulation of cell migration [GO:0030334]; regulation of cell motility [GO:2000145]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of neuron differentiation [GO:0045664]; regulation of stress fiber assembly [GO:0051492]; regulation of synapse maturation [GO:0090128]; regulation of synaptic vesicle endocytosis [GO:1900242]; response to angiotensin [GO:1990776]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]	bleb [GO:0032059]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule lumen [GO:0034774]	aspartic-type endopeptidase inhibitor activity [GO:0019828]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; small GTPase binding [GO:0031267]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	bleb [GO:0032059]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule lumen [GO:0034774]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; small GTPase binding [GO:0031267]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; aortic valve morphogenesis [GO:0003180]; apical constriction [GO:0003383]; bleb assembly [GO:0032060]; blood vessel diameter maintenance [GO:0097746]; canonical NF-kappaB signal transduction [GO:0007249]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; epithelial to mesenchymal transition [GO:0001837]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; mitotic cytokinesis [GO:0000281]; motor neuron apoptotic process [GO:0097049]; mRNA destabilization [GO:0061157]; myoblast migration [GO:0051451]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; negative regulation of phosphorylation [GO:0042326]; negative regulation of protein binding [GO:0032091]; neuron projection arborization [GO:0140058]; neuron projection development [GO:0031175]; peptidyl-serine phosphorylation [GO:0018105]; podocyte cell migration [GO:0090521]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of autophagy [GO:0010508]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatase activity [GO:0010922]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of amyloid-beta formation [GO:1902003]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of autophagy [GO:0010506]; regulation of cell adhesion [GO:0030155]; regulation of cell junction assembly [GO:1901888]; regulation of cell migration [GO:0030334]; regulation of cell motility [GO:2000145]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of neuron differentiation [GO:0045664]; regulation of stress fiber assembly [GO:0051492]; regulation of synapse maturation [GO:0090128]; regulation of synaptic vesicle endocytosis [GO:1900242]; response to angiotensin [GO:1990776]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8617235}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:P70335}. Golgi apparatus membrane {ECO:0000269|PubMed:12773565}; Peripheral membrane protein {ECO:0000269|PubMed:12773565}. Cell projection, bleb {ECO:0000269|PubMed:18694941}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P70335}. Cell membrane {ECO:0000250|UniProtKB:P70335}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P70335}. Cell projection, ruffle {ECO:0000250|UniProtKB:P70335}. Note=A small proportion is associated with Golgi membranes (PubMed:12773565). Associated with the mother centriole and an intercentriolar linker (By similarity). Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers (By similarity). Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000269|PubMed:12773565}.
Q13467	reviewed	FZD5_HUMAN	Frizzled-5 (Fz-5) (hFz5) (FzE5)	FZD5 C2orf31	Homo sapiens (Human)	585	FUNCTION: Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). {ECO:0000250|UniProtKB:Q9EQD0, ECO:0000269|PubMed:10097073, ECO:0000269|PubMed:20530549, ECO:0000269|PubMed:9054360, ECO:0000305}.		angiogenesis [GO:0001525]; anterior/posterior axis specification, embryo [GO:0008595]; apoptotic process involved in morphogenesis [GO:0060561]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; cellular response to molecule of bacterial origin [GO:0071219]; chorionic trophoblast cell differentiation [GO:0060718]; embryonic axis specification [GO:0000578]; embryonic camera-type eye morphogenesis [GO:0048596]; glandular epithelial cell maturation [GO:0002071]; intestinal epithelial cell maturation [GO:0060574]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell population proliferation [GO:0008285]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; post-embryonic camera-type eye development [GO:0031077]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of chorionic trophoblast cell proliferation [GO:1901382]; Spemann organizer formation [GO:0060061]; synapse assembly [GO:0007416]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell differentiation in thymus [GO:0033077]	axon [GO:0030424]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]	amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	axon [GO:0030424]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; angiogenesis [GO:0001525]; anterior/posterior axis specification, embryo [GO:0008595]; apoptotic process involved in morphogenesis [GO:0060561]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; cellular response to molecule of bacterial origin [GO:0071219]; chorionic trophoblast cell differentiation [GO:0060718]; embryonic axis specification [GO:0000578]; embryonic camera-type eye morphogenesis [GO:0048596]; glandular epithelial cell maturation [GO:0002071]; intestinal epithelial cell maturation [GO:0060574]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell population proliferation [GO:0008285]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; post-embryonic camera-type eye development [GO:0031077]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of chorionic trophoblast cell proliferation [GO:1901382]; Spemann organizer formation [GO:0060061]; synapse assembly [GO:0007416]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell differentiation in thymus [GO:0033077]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8CHL0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CHL0}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EQD0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9EQD0}. Synapse {ECO:0000250|UniProtKB:Q8CHL0}. Perikaryon {ECO:0000250|UniProtKB:Q8CHL0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8CHL0}. Cell projection, axon {ECO:0000250|UniProtKB:Q8CHL0}. Note=Localized at the plasma membrane and also found at the Golgi. {ECO:0000250|UniProtKB:Q9EQD0}.
Q13469	reviewed	NFAC2_HUMAN	Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)	NFATC2 NFAT1 NFATP	Homo sapiens (Human)	925	FUNCTION: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). {ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}.		B cell receptor signaling pathway [GO:0050853]; calcineurin-NFAT signaling cascade [GO:0033173]; cartilage development [GO:0051216]; cell migration [GO:0016477]; cellular response to calcium ion [GO:0071277]; DNA damage response [GO:0006974]; myotube cell development [GO:0014904]; ncRNA transcription [GO:0098781]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of myoblast fusion [GO:1901741]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667]	14-3-3 protein binding [GO:0071889]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; molecular adaptor activity [GO:0060090]; phosphatase binding [GO:0019902]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667]; 14-3-3 protein binding [GO:0071889]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; molecular adaptor activity [GO:0060090]; phosphatase binding [GO:0019902]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; B cell receptor signaling pathway [GO:0050853]; calcineurin-NFAT signaling cascade [GO:0033173]; cartilage development [GO:0051216]; cell migration [GO:0016477]; cellular response to calcium ion [GO:0071277]; DNA damage response [GO:0006974]; myotube cell development [GO:0014904]; ncRNA transcription [GO:0098781]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of myoblast fusion [GO:1901741]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Q13470	reviewed	TNK1_HUMAN	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)	TNK1	Homo sapiens (Human)	666	FUNCTION: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}.		protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; membrane [GO:0016020]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; membrane [GO:0016020]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10873601}. Membrane {ECO:0000269|PubMed:10873601}; Peripheral membrane protein {ECO:0000269|PubMed:10873601}.
Q13472	reviewed	TOP3A_HUMAN	DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha)	TOP3A TOP3	Homo sapiens (Human)	1001	FUNCTION: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity (PubMed:30057030). It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2 (PubMed:29290614). {ECO:0000269|PubMed:20445207, ECO:0000269|PubMed:29290614, ECO:0000269|PubMed:30057030, ECO:0000269|PubMed:8622991}.		chromosome separation [GO:0051304]; DNA topological change [GO:0006265]; double-strand break repair via homologous recombination [GO:0000724]; meiotic cell cycle [GO:0051321]; mitochondrial DNA metabolic process [GO:0032042]; resolution of recombination intermediates [GO:0071139]	mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; RecQ family helicase-topoisomerase III complex [GO:0031422]	DNA binding [GO:0003677]; DNA topoisomerase activity [GO:0003916]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; RecQ family helicase-topoisomerase III complex [GO:0031422]; DNA binding [GO:0003677]; DNA topoisomerase activity [GO:0003916]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270]; chromosome separation [GO:0051304]; DNA topological change [GO:0006265]; double-strand break repair via homologous recombination [GO:0000724]; meiotic cell cycle [GO:0051321]; mitochondrial DNA metabolic process [GO:0032042]; resolution of recombination intermediates [GO:0071139]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:29290614}.
Q13477	reviewed	MADCA_HUMAN	Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1)	MADCAM1	Homo sapiens (Human)	382	FUNCTION: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.		cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte migration [GO:2000403]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]	membrane [GO:0016020]; plasma membrane [GO:0005886]	integrin binding involved in cell-matrix adhesion [GO:0098640]	membrane [GO:0016020]; plasma membrane [GO:0005886]; integrin binding involved in cell-matrix adhesion [GO:0098640]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte migration [GO:2000403]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q13478	reviewed	IL18R_HUMAN	Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)	IL18R1 IL1RRP	Homo sapiens (Human)	541	FUNCTION: Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). {ECO:0000250|UniProtKB:Q61098, ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25261253, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:8626725}.		immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-18-mediated signaling pathway [GO:0035655]; natural killer cell activation [GO:0030101]; negative regulation of cold-induced thermogenesis [GO:0120163]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165]; T-helper 1 cell differentiation [GO:0045063]	interleukin-18 receptor complex [GO:0045092]; plasma membrane [GO:0005886]	interleukin-1 receptor activity [GO:0004908]; interleukin-18 binding [GO:0042007]; interleukin-18 receptor activity [GO:0042008]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]	interleukin-18 receptor complex [GO:0045092]; plasma membrane [GO:0005886]; interleukin-1 receptor activity [GO:0004908]; interleukin-18 binding [GO:0042007]; interleukin-18 receptor activity [GO:0042008]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-18-mediated signaling pathway [GO:0035655]; natural killer cell activation [GO:0030101]; negative regulation of cold-induced thermogenesis [GO:0120163]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165]; T-helper 1 cell differentiation [GO:0045063]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:14528293}; Single-pass type I membrane protein {ECO:0000305}.
Q13480	reviewed	GAB1_HUMAN	GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)	GAB1	Homo sapiens (Human)	694	FUNCTION: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}.		angiogenesis [GO:0001525]; endothelial cell chemotaxis to vascular endothelial growth factor [GO:0090668]; epidermal growth factor receptor signaling pathway [GO:0007173]; insulin receptor signaling pathway [GO:0008286]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration by vascular endothelial growth factor signaling pathway [GO:0038089]; response to hepatocyte growth factor [GO:0035728]; signal transduction [GO:0007165]; vascular endothelial growth factor signaling pathway [GO:0038084]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	signaling adaptor activity [GO:0035591]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; signaling adaptor activity [GO:0035591]; angiogenesis [GO:0001525]; endothelial cell chemotaxis to vascular endothelial growth factor [GO:0090668]; epidermal growth factor receptor signaling pathway [GO:0007173]; insulin receptor signaling pathway [GO:0008286]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration by vascular endothelial growth factor signaling pathway [GO:0038089]; response to hepatocyte growth factor [GO:0035728]; signal transduction [GO:0007165]; vascular endothelial growth factor signaling pathway [GO:0038084]	
Q13485	reviewed	SMAD4_HUMAN	Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)	SMAD4 DPC4 MADH4	Homo sapiens (Human)	552	FUNCTION: In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling (PubMed:25514493). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000250, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:9389648}.		activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; atrioventricular canal development [GO:0036302]; atrioventricular valve formation [GO:0003190]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; brainstem development [GO:0003360]; branching involved in ureteric bud morphogenesis [GO:0001658]; cardiac conduction system development [GO:0003161]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; cellular response to glucose stimulus [GO:0071333]; developmental growth [GO:0048589]; DNA-templated transcription [GO:0006351]; embryonic digit morphogenesis [GO:0042733]; endocardial cell differentiation [GO:0060956]; endothelial cell activation [GO:0042118]; epithelial cell migration [GO:0010631]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; ERK1 and ERK2 cascade [GO:0070371]; female gonad morphogenesis [GO:0061040]; formation of anatomical boundary [GO:0048859]; gastrulation with mouth forming second [GO:0001702]; in utero embryonic development [GO:0001701]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular iron ion homeostasis [GO:0006879]; intracellular signal transduction [GO:0035556]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; mesendoderm development [GO:0048382]; metanephric mesenchyme morphogenesis [GO:0072133]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cardiac myofibril assembly [GO:1905305]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neural crest cell differentiation [GO:0014033]; neuron fate commitment [GO:0048663]; osteoblast differentiation [GO:0001649]; outflow tract septum morphogenesis [GO:0003148]; ovarian follicle development [GO:0001541]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell proliferation involved in heart valve morphogenesis [GO:0003251]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of hair follicle development [GO:0051797]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; response to transforming growth factor beta [GO:0071559]; sebaceous gland development [GO:0048733]; secondary palate development [GO:0062009]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; SMAD protein signal transduction [GO:0060395]; somite rostral/caudal axis specification [GO:0032525]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065]; ventricular septum morphogenesis [GO:0060412]	activin responsive factor complex [GO:0032444]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMAD protein complex [GO:0071141]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; collagen binding [GO:0005518]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; filamin binding [GO:0031005]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sulfate binding [GO:0043199]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]	activin responsive factor complex [GO:0032444]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMAD protein complex [GO:0071141]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; collagen binding [GO:0005518]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; filamin binding [GO:0031005]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sulfate binding [GO:0043199]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; atrioventricular canal development [GO:0036302]; atrioventricular valve formation [GO:0003190]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; brainstem development [GO:0003360]; branching involved in ureteric bud morphogenesis [GO:0001658]; cardiac conduction system development [GO:0003161]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; cellular response to glucose stimulus [GO:0071333]; developmental growth [GO:0048589]; DNA-templated transcription [GO:0006351]; embryonic digit morphogenesis [GO:0042733]; endocardial cell differentiation [GO:0060956]; endothelial cell activation [GO:0042118]; epithelial cell migration [GO:0010631]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; ERK1 and ERK2 cascade [GO:0070371]; female gonad morphogenesis [GO:0061040]; formation of anatomical boundary [GO:0048859]; gastrulation with mouth forming second [GO:0001702]; in utero embryonic development [GO:0001701]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular iron ion homeostasis [GO:0006879]; intracellular signal transduction [GO:0035556]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; mesendoderm development [GO:0048382]; metanephric mesenchyme morphogenesis [GO:0072133]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cardiac myofibril assembly [GO:1905305]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neural crest cell differentiation [GO:0014033]; neuron fate commitment [GO:0048663]; osteoblast differentiation [GO:0001649]; outflow tract septum morphogenesis [GO:0003148]; ovarian follicle development [GO:0001541]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell proliferation involved in heart valve morphogenesis [GO:0003251]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of hair follicle development [GO:0051797]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; response to transforming growth factor beta [GO:0071559]; sebaceous gland development [GO:0048733]; secondary palate development [GO:0062009]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; SMAD protein signal transduction [GO:0060395]; somite rostral/caudal axis specification [GO:0032525]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:17327236}. Nucleus {ECO:0000269|PubMed:15799969}. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD (PubMed:15799969). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236). {ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:17327236}.
Q13487	reviewed	SNPC2_HUMAN	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE-binding factor subunit delta) (PTF subunit delta) (Small nuclear RNA-activating complex polypeptide 2) (snRNA-activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit)	SNAPC2 SNAP45	Homo sapiens (Human)	334	FUNCTION: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.		snRNA transcription [GO:0009301]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA polymerase II general transcription initiation factor activity [GO:0016251]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; snRNA transcription [GO:0009301]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus.
Q13488	reviewed	VPP3_HUMAN	V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3)	TCIRG1 ATP6N1C ATP6V0A3	Homo sapiens (Human)	830	FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Seems to be directly involved in T-cell activation (PubMed:10329006). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:10329006}.		apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; B cell differentiation [GO:0030183]; bone resorption [GO:0045453]; cellular defense response [GO:0006968]; cellular response to cytokine stimulus [GO:0071345]; dentin mineralization [GO:0097188]; enamel mineralization [GO:0070166]; establishment of cell polarity [GO:0030010]; establishment of vesicle localization [GO:0051650]; gene expression [GO:0010467]; hematopoietic stem cell homeostasis [GO:0061484]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lysosomal lumen acidification [GO:0007042]; macroautophagy [GO:0016236]; memory T cell activation [GO:0035709]; optic nerve development [GO:0021554]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; pH reduction [GO:0045851]; phagosome acidification [GO:0090383]; positive regulation of cell population proliferation [GO:0008284]; protein catabolic process in the vacuole [GO:0007039]; protein localization to organelle [GO:0033365]; proton transmembrane transport [GO:1902600]; regulation of gene expression [GO:0010468]; regulation of insulin secretion [GO:0050796]; regulation of osteoblast differentiation [GO:0045667]; regulation of proton transport [GO:0010155]; response to silver ion [GO:0010272]; retina development in camera-type eye [GO:0060041]; ruffle organization [GO:0031529]; T cell differentiation [GO:0030217]; T cell homeostasis [GO:0043029]; T-helper 1 cell activation [GO:0035711]; tooth eruption [GO:0044691]; vacuolar acidification [GO:0007035]	apical plasma membrane [GO:0016324]; endosome membrane [GO:0010008]; ficolin-1-rich granule membrane [GO:0101003]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical plasma membrane [GO:0016324]; endosome membrane [GO:0010008]; ficolin-1-rich granule membrane [GO:0101003]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; B cell differentiation [GO:0030183]; bone resorption [GO:0045453]; cellular defense response [GO:0006968]; cellular response to cytokine stimulus [GO:0071345]; dentin mineralization [GO:0097188]; enamel mineralization [GO:0070166]; establishment of cell polarity [GO:0030010]; establishment of vesicle localization [GO:0051650]; gene expression [GO:0010467]; hematopoietic stem cell homeostasis [GO:0061484]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lysosomal lumen acidification [GO:0007042]; macroautophagy [GO:0016236]; memory T cell activation [GO:0035709]; optic nerve development [GO:0021554]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; pH reduction [GO:0045851]; phagosome acidification [GO:0090383]; positive regulation of cell population proliferation [GO:0008284]; protein catabolic process in the vacuole [GO:0007039]; protein localization to organelle [GO:0033365]; proton transmembrane transport [GO:1902600]; regulation of gene expression [GO:0010468]; regulation of insulin secretion [GO:0050796]; regulation of osteoblast differentiation [GO:0045667]; regulation of proton transport [GO:0010155]; response to silver ion [GO:0010272]; retina development in camera-type eye [GO:0060041]; ruffle organization [GO:0031529]; T cell differentiation [GO:0030217]; T cell homeostasis [GO:0043029]; T-helper 1 cell activation [GO:0035711]; tooth eruption [GO:0044691]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q13489	reviewed	BIRC3_HUMAN	Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)	BIRC3 API2 MIHC RNF49	Homo sapiens (Human)	604	FUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. {ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969}.		apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; spermatogenesis [GO:0007283]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; transferase activity [GO:0016740]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; transferase activity [GO:0016740]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; spermatogenesis [GO:0007283]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15665297}. Nucleus {ECO:0000269|PubMed:15665297}.
Q13490	reviewed	BIRC2_HUMAN	Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)	BIRC2 API1 MIHB RNF48	Homo sapiens (Human)	618	FUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. {ECO:0000269|PubMed:15665297, ECO:0000269|PubMed:18082613, ECO:0000269|PubMed:21145488, ECO:0000269|PubMed:21653699, ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969}.		apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; negative regulation of ripoptosome assembly involved in necroptotic process [GO:1902443]; non-canonical NF-kappaB signal transduction [GO:0038061]; placenta development [GO:0001890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nucleus [GO:0005634]; XY body [GO:0001741]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; FBXO family protein binding [GO:0098770]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transcription coactivator activity [GO:0003713]; transferase activity [GO:0016740]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nucleus [GO:0005634]; XY body [GO:0001741]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; FBXO family protein binding [GO:0098770]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transcription coactivator activity [GO:0003713]; transferase activity [GO:0016740]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; negative regulation of ripoptosome assembly involved in necroptotic process [GO:1902443]; non-canonical NF-kappaB signal transduction [GO:0038061]; placenta development [GO:0001890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.
Q13491	reviewed	GPM6B_HUMAN	Neuronal membrane glycoprotein M6-b (M6b)	GPM6B M6B	Homo sapiens (Human)	265	FUNCTION: May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. {ECO:0000269|PubMed:21638316}.		axon development [GO:0061564]; central nervous system myelination [GO:0022010]; extracellular matrix assembly [GO:0085029]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of serotonin uptake [GO:0051612]; nervous system development [GO:0007399]; ossification [GO:0001503]; positive regulation of bone mineralization [GO:0030501]; protein transport [GO:0015031]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of focal adhesion assembly [GO:0051893]	membrane raft [GO:0045121]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]	structural constituent of myelin sheath [GO:0019911]	membrane raft [GO:0045121]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; structural constituent of myelin sheath [GO:0019911]; axon development [GO:0061564]; central nervous system myelination [GO:0022010]; extracellular matrix assembly [GO:0085029]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of serotonin uptake [GO:0051612]; nervous system development [GO:0007399]; ossification [GO:0001503]; positive regulation of bone mineralization [GO:0030501]; protein transport [GO:0015031]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of focal adhesion assembly [GO:0051893]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with SERT at the plasma membrane. {ECO:0000250}.
Q13492	reviewed	PICAL_HUMAN	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)	PICALM CALM	Homo sapiens (Human)	652	FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.		amyloid-beta clearance by transcytosis [GO:0150093]; axonogenesis [GO:0007409]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; dendrite morphogenesis [GO:0048813]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; learning or memory [GO:0007611]; membrane bending [GO:0097753]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of gene expression [GO:0010629]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of receptor-mediated endocytosis [GO:0048261]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of GTPase activity [GO:0043547]; protein-containing complex assembly [GO:0065003]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902959]; regulation of endocytosis [GO:0030100]; regulation of protein localization [GO:0032880]; regulation of vesicle size [GO:0097494]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]; synaptic vesicle maturation [GO:0016188]; vesicle budding from membrane [GO:0006900]; vesicle cargo loading [GO:0035459]; vesicle-mediated transport [GO:0016192]	cell surface [GO:0009986]; clathrin coat of coated pit [GO:0030132]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome to plasma membrane transport vesicle [GO:0070381]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neurofibrillary tangle [GO:0097418]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]	1-phosphatidylinositol binding [GO:0005545]; amyloid-beta binding [GO:0001540]; cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; clathrin heavy chain binding [GO:0032050]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; tau protein binding [GO:0048156]	cell surface [GO:0009986]; clathrin coat of coated pit [GO:0030132]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome to plasma membrane transport vesicle [GO:0070381]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neurofibrillary tangle [GO:0097418]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]; 1-phosphatidylinositol binding [GO:0005545]; amyloid-beta binding [GO:0001540]; cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; clathrin heavy chain binding [GO:0032050]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; tau protein binding [GO:0048156]; amyloid-beta clearance by transcytosis [GO:0150093]; axonogenesis [GO:0007409]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; dendrite morphogenesis [GO:0048813]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; learning or memory [GO:0007611]; membrane bending [GO:0097753]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of gene expression [GO:0010629]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of receptor-mediated endocytosis [GO:0048261]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of GTPase activity [GO:0043547]; protein-containing complex assembly [GO:0065003]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902959]; regulation of endocytosis [GO:0030100]; regulation of protein localization [GO:0032880]; regulation of vesicle size [GO:0097494]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]; synaptic vesicle maturation [GO:0016188]; vesicle budding from membrane [GO:0006900]; vesicle cargo loading [GO:0035459]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16262731}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:10436022}. Golgi apparatus {ECO:0000269|PubMed:10436022}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:10436022}. Nucleus {ECO:0000269|PubMed:16491119}. Note=Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16491119}.
Q13495	reviewed	MAMD1_HUMAN	Mastermind-like domain-containing protein 1 (F18) (Protein CG1)	MAMLD1 CG1 CXorf6	Homo sapiens (Human)	774	FUNCTION: Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}.		male gonad development [GO:0008584]; regulation of transcription by RNA polymerase II [GO:0006357]	centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]		centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; male gonad development [GO:0008584]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18162467}. Note=Punctate nuclear localization.
Q13496	reviewed	MTM1_HUMAN	Myotubularin (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)	MTM1 CG2	Homo sapiens (Human)	603	FUNCTION: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:11001925, PubMed:10900271, PubMed:12646134, PubMed:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508). Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870). {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:14722070, ECO:0000269|PubMed:21135508, ECO:0000269|PubMed:23818870, ECO:0000269|PubMed:9537414}.		autophagosome assembly [GO:0000045]; endosome to lysosome transport [GO:0008333]; intermediate filament organization [GO:0045109]; mitochondrion distribution [GO:0048311]; mitochondrion morphogenesis [GO:0070584]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of TOR signaling [GO:0032007]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of skeletal muscle tissue growth [GO:0048633]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein transport [GO:0015031]; regulation of vacuole organization [GO:0044088]; skeletal muscle tissue growth [GO:0048630]; TOR signaling [GO:0031929]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; I band [GO:0031674]; late endosome [GO:0005770]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	intermediate filament binding [GO:0019215]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; I band [GO:0031674]; late endosome [GO:0005770]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; intermediate filament binding [GO:0019215]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; autophagosome assembly [GO:0000045]; endosome to lysosome transport [GO:0008333]; intermediate filament organization [GO:0045109]; mitochondrion distribution [GO:0048311]; mitochondrion morphogenesis [GO:0070584]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of TOR signaling [GO:0032007]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of skeletal muscle tissue growth [GO:0048633]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein transport [GO:0015031]; regulation of vacuole organization [GO:0044088]; skeletal muscle tissue growth [GO:0048630]; TOR signaling [GO:0031929]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12847286}. Cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12847286}. Cell projection, filopodium {ECO:0000269|PubMed:12118066}. Cell projection, ruffle {ECO:0000269|PubMed:12118066}. Late endosome {ECO:0000269|PubMed:14722070}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q9Z2C5}. Note=Localizes as a dense cytoplasmic network (PubMed:11001925). Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles (PubMed:12118066). Predominantly located in the cytoplasm following interaction with MTMR12 (PubMed:12847286). Recruited to the late endosome following EGF stimulation (PubMed:14722070). In skeletal muscles, co-localizes with MTMR12 in the sarcomere (By similarity). {ECO:0000250|UniProtKB:Q9Z2C5, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12118066, ECO:0000269|PubMed:12847286, ECO:0000269|PubMed:14722070}.
Q13501	reviewed	SQSTM_HUMAN	Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)	SQSTM1 ORCA OSIL	Homo sapiens (Human)	440	FUNCTION: Autophagy receptor required for selective macroautophagy (aggrephagy) (PubMed:34471133, PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177, PubMed:33509017). Functions as a bridge between polyubiquitinated cargo and autophagosomes (PubMed:34471133). Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). {ECO:0000250|UniProtKB:O08623, ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133}.		aggrephagy [GO:0035973]; apoptotic process [GO:0006915]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; brown fat cell proliferation [GO:0070342]; cell differentiation [GO:0030154]; cellular response to reactive oxygen species [GO:0034614]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; energy homeostasis [GO:0097009]; immune system process [GO:0002376]; intracellular signal transduction [GO:0035556]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pexophagy [GO:0000425]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein targeting to vacuole involved in autophagy [GO:0071211]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of mitochondrion organization [GO:0010821]; regulation of protein complex stability [GO:0061635]; regulation of Ras protein signal transduction [GO:0046578]; response to ischemia [GO:0002931]; response to mitochondrial depolarisation [GO:0098780]; selective autophagy [GO:0061912]; temperature homeostasis [GO:0001659]; transcription by RNA polymerase II [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]	aggresome [GO:0016235]; amphisome [GO:0044753]; autolysosome [GO:0044754]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; inclusion body [GO:0016234]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; Lewy body [GO:0097413]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; phagophore assembly site [GO:0000407]; PML body [GO:0016605]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor activity [GO:0038023]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-dependent protein binding [GO:0140036]; zinc ion binding [GO:0008270]	aggresome [GO:0016235]; amphisome [GO:0044753]; autolysosome [GO:0044754]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; inclusion body [GO:0016234]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; Lewy body [GO:0097413]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; phagophore assembly site [GO:0000407]; PML body [GO:0016605]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor activity [GO:0038023]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-dependent protein binding [GO:0140036]; zinc ion binding [GO:0008270]; aggrephagy [GO:0035973]; apoptotic process [GO:0006915]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; brown fat cell proliferation [GO:0070342]; cell differentiation [GO:0030154]; cellular response to reactive oxygen species [GO:0034614]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; energy homeostasis [GO:0097009]; immune system process [GO:0002376]; intracellular signal transduction [GO:0035556]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pexophagy [GO:0000425]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein targeting to vacuole involved in autophagy [GO:0071211]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of mitochondrion organization [GO:0010821]; regulation of protein complex stability [GO:0061635]; regulation of Ras protein signal transduction [GO:0046578]; response to ischemia [GO:0002931]; response to mitochondrial depolarisation [GO:0098780]; selective autophagy [GO:0061912]; temperature homeostasis [GO:0001659]; transcription by RNA polymerase II [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:22792322}. Preautophagosomal structure {ECO:0000269|PubMed:34471133}. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Nucleus, PML body {ECO:0000269|PubMed:20168092}. Cytoplasm, myofibril, sarcomere {ECO:0000250}. Note=In cardiac muscle, localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiquitin-containing protein aggregates (sequestosomes) and membrane-surrounded autophagosomes. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum. Co-localizes with TRIM5 in cytoplasmic bodies. When nuclear export is blocked by treatment with leptomycin B, accumulates in PML bodies. {ECO:0000269|PubMed:20168092}.
Q13503	reviewed	MED21_HUMAN	Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7) (hSrb7)	MED21 SRB7 SURB7	Homo sapiens (Human)	144	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15249124, ECO:0000269|PubMed:9660976}.		blastocyst development [GO:0001824]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]; blastocyst development [GO:0001824]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q13505	reviewed	MTX1_HUMAN	Metaxin-1 (Mitochondrial outer membrane import complex protein 1)	MTX1 MTX MTXN	Homo sapiens (Human)	466	FUNCTION: Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity). {ECO:0000250}.		inner mitochondrial membrane organization [GO:0007007]; lactation [GO:0007595]; mitochondrion organization [GO:0007005]; protein insertion into mitochondrial outer membrane [GO:0045040]	cytoplasm [GO:0005737]; membrane [GO:0016020]; MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; SAM complex [GO:0001401]		cytoplasm [GO:0005737]; membrane [GO:0016020]; MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; SAM complex [GO:0001401]; inner mitochondrial membrane organization [GO:0007007]; lactation [GO:0007595]; mitochondrion organization [GO:0007005]; protein insertion into mitochondrial outer membrane [GO:0045040]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion outer membrane {ECO:0000250}.
Q13506	reviewed	NAB1_HUMAN	NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54)	NAB1	Homo sapiens (Human)	487	FUNCTION: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. {ECO:0000250}.		endochondral ossification [GO:0001958]; myelination [GO:0042552]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of epidermis development [GO:0045682]; Schwann cell differentiation [GO:0014037]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coregulator activity [GO:0003712]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coregulator activity [GO:0003712]; endochondral ossification [GO:0001958]; myelination [GO:0042552]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of epidermis development [GO:0045682]; Schwann cell differentiation [GO:0014037]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q13507	reviewed	TRPC3_HUMAN	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (TRP-3) (hTrp-3) (hTrp3)	TRPC3 TRP3	Homo sapiens (Human)	921	FUNCTION: Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:8646775, PubMed:9417057, PubMed:9930701, PubMed:20095964, PubMed:30139744, PubMed:29726814, PubMed:35051376). May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors (PubMed:8646775). {ECO:0000269|PubMed:20095964, ECO:0000269|PubMed:29726814, ECO:0000269|PubMed:30139744, ECO:0000269|PubMed:35051376, ECO:0000269|PubMed:8646775, ECO:0000269|PubMed:9417057, ECO:0000269|PubMed:9930701}.		calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; phototransduction [GO:0007602]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; single fertilization [GO:0007338]	cation channel complex [GO:0034703]; plasma membrane [GO:0005886]	calcium activated cation channel activity [GO:0005227]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; metal ion binding [GO:0046872]; store-operated calcium channel activity [GO:0015279]	cation channel complex [GO:0034703]; plasma membrane [GO:0005886]; calcium activated cation channel activity [GO:0005227]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; metal ion binding [GO:0046872]; store-operated calcium channel activity [GO:0015279]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; phototransduction [GO:0007602]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q13508	reviewed	NAR3_HUMAN	Ecto-ADP-ribosyltransferase 3 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 3) (ARTC3) (Mono(ADP-ribosyl)transferase 3) (NAD(P)(+)--arginine ADP-ribosyltransferase 3)	ART3 TMART	Homo sapiens (Human)	389				extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
Q13509	reviewed	TBB3_HUMAN	Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III)	TUBB3 TUBB4	Homo sapiens (Human)	450	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:34996871). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871}.		axon guidance [GO:0007411]; dorsal root ganglion development [GO:1990791]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	axon [GO:0030424]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; netrin receptor binding [GO:1990890]; peptide binding [GO:0042277]; structural constituent of cytoskeleton [GO:0005200]	axon [GO:0030424]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; netrin receptor binding [GO:1990890]; peptide binding [GO:0042277]; structural constituent of cytoskeleton [GO:0005200]; axon guidance [GO:0007411]; dorsal root ganglion development [GO:1990791]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:35482892}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9ERD7}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9ERD7}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9ERD7}.
Q13510	reviewed	ASAH1_HUMAN	Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylethanolamine hydrolase ASAH1) (EC 3.5.1.-) (N-acylsphingosine amidohydrolase) (Putative 32 kDa heart protein) (PHP32) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta]	ASAH1 ASAH HSD-33 HSD33	Homo sapiens (Human)	395	FUNCTION: Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (PubMed:10610716, PubMed:7744740, PubMed:15655246, PubMed:11451951). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:10610716). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (PubMed:7744740, PubMed:15655246). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:12764132, PubMed:12815059). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (PubMed:12764132). Has also an N-acylethanolamine hydrolase activity (PubMed:15655246). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (PubMed:17713573). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (PubMed:22261821). {ECO:0000250|UniProtKB:Q9WV54, ECO:0000269|PubMed:10610716, ECO:0000269|PubMed:11451951, ECO:0000269|PubMed:12764132, ECO:0000269|PubMed:12815059, ECO:0000269|PubMed:15655246, ECO:0000269|PubMed:17713573, ECO:0000269|PubMed:22261821, ECO:0000269|PubMed:7744740, ECO:0000303|PubMed:10610716}.; FUNCTION: [Isoform 2]: May directly regulate steroidogenesis by binding the nuclear receptor NR5A1 and negatively regulating its transcriptional activity. {ECO:0000305|PubMed:22927646}.	MISCELLANEOUS: [Isoform 2]: Mutagenesis in position: 25:L->A (Loss of interaction with NR5A1). {ECO:0000269|PubMed:22927646, ECO:0000305}.	cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; ceramide catabolic process [GO:0046514]; fatty acid metabolic process [GO:0006631]; keratinocyte differentiation [GO:0030216]; regulation of programmed necrotic cell death [GO:0062098]; regulation of steroid biosynthetic process [GO:0050810]; sphingosine biosynthetic process [GO:0046512]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]	ceramidase activity [GO:0102121]; fatty acid amide hydrolase activity [GO:0017064]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; N-acylsphingosine amidohydrolase activity [GO:0017040]; nuclear receptor binding [GO:0016922]; transcription corepressor activity [GO:0003714]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]; ceramidase activity [GO:0102121]; fatty acid amide hydrolase activity [GO:0017064]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; N-acylsphingosine amidohydrolase activity [GO:0017040]; nuclear receptor binding [GO:0016922]; transcription corepressor activity [GO:0003714]; cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; ceramide catabolic process [GO:0046514]; fatty acid metabolic process [GO:0006631]; keratinocyte differentiation [GO:0030216]; regulation of programmed necrotic cell death [GO:0062098]; regulation of steroid biosynthetic process [GO:0050810]; sphingosine biosynthetic process [GO:0046512]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:12764132}. Secreted {ECO:0000269|PubMed:7744740}. Note=Secretion is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent. {ECO:0000269|PubMed:11451951}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000305|PubMed:22927646}. Cytoplasm {ECO:0000305|PubMed:22927646}. Note=A localization to the nucleus and the cytoplasm has also been reported for ASAH1, most probably for isoforms devoid of a signal peptide. {ECO:0000305|PubMed:22927646}.
Q13515	reviewed	BFSP2_HUMAN	Phakinin (49 kDa cytoskeletal protein) (Beaded filament structural protein 2) (Lens fiber cell beaded filament protein CP 47) (CP47) (Lens fiber cell beaded filament protein CP 49) (CP49) (Lens intermediate filament-like light) (LIFL-L)	BFSP2	Homo sapiens (Human)	415	FUNCTION: Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:28935373). Plays a role in maintenance of retinal lens optical clarity (By similarity). {ECO:0000250|UniProtKB:Q6NVD9, ECO:0000269|PubMed:28935373}.		cell maturation [GO:0048469]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886]	structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212]	cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212]; cell maturation [GO:0048469]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q28177}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q28177}; Cytoplasmic side {ECO:0000250|UniProtKB:Q28177}. Cytoplasm {ECO:0000250|UniProtKB:D3ZER2}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q28177}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q28177}. Note=Expressed primarily at the plasma membrane in peripheral lens fiber cells, however also localizes to the cytoplasm in mature lens fiber cells. {ECO:0000250|UniProtKB:Q28177}.
Q13516	reviewed	OLIG2_HUMAN	Oligodendrocyte transcription factor 2 (Oligo2) (Class B basic helix-loop-helix protein 1) (bHLHb1) (Class E basic helix-loop-helix protein 19) (bHLHe19) (Protein kinase C-binding protein 2) (Protein kinase C-binding protein RACK17)	OLIG2 BHLHB1 BHLHE19 PRKCBP2 RACK17	Homo sapiens (Human)	323	FUNCTION: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. {ECO:0000250|UniProtKB:Q9EQW6}.		axon development [GO:0061564]; myelination [GO:0042552]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate commitment [GO:0048663]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; spinal cord motor neuron differentiation [GO:0021522]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; thalamus development [GO:0021794]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; HMG box domain binding [GO:0071837]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; HMG box domain binding [GO:0071837]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]; axon development [GO:0061564]; myelination [GO:0042552]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate commitment [GO:0048663]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; spinal cord motor neuron differentiation [GO:0021522]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; thalamus development [GO:0021794]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. Cytoplasm {ECO:0000250}. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. {ECO:0000250}.
Q13519	reviewed	PNOC_HUMAN	Prepronociceptin [Cleaved into: Nocistatin; Nociceptin (Orphanin FQ) (PPNOC); Orphanin FQ2]	PNOC OFQ	Homo sapiens (Human)	176	FUNCTION: [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. {ECO:0000250|UniProtKB:P55791}.; FUNCTION: [Nocistatin]: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. {ECO:0000250|UniProtKB:O62647}.; FUNCTION: [Orphanin FQ2]: Has potent analgesic activity. {ECO:0000250|UniProtKB:Q64387}.		chemical synaptic transmission [GO:0007268]; female pregnancy [GO:0007565]; neuropeptide signaling pathway [GO:0007218]; sensory perception [GO:0007600]; signal transduction [GO:0007165]	axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	neuropeptide hormone activity [GO:0005184]; opioid peptide activity [GO:0001515]; opioid receptor binding [GO:0031628]	axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; neuropeptide hormone activity [GO:0005184]; opioid peptide activity [GO:0001515]; opioid receptor binding [GO:0031628]; chemical synaptic transmission [GO:0007268]; female pregnancy [GO:0007565]; neuropeptide signaling pathway [GO:0007218]; sensory perception [GO:0007600]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
Q13520	reviewed	AQP6_HUMAN	Aquaporin-6 (AQP-6) (Aquaporin-2-like) (Kidney-specific aquaporin) (hKID)	AQP6 AQP2L	Homo sapiens (Human)	282	FUNCTION: Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism. {ECO:0000250}.		carbon dioxide transport [GO:0015670]; odontogenesis [GO:0042476]; renal water transport [GO:0003097]; water transport [GO:0006833]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886]	nitrate transmembrane transporter activity [GO:0015112]; water channel activity [GO:0015250]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886]; nitrate transmembrane transporter activity [GO:0015112]; water channel activity [GO:0015250]; carbon dioxide transport [GO:0015670]; odontogenesis [GO:0042476]; renal water transport [GO:0003097]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q13522	reviewed	PPR1A_HUMAN	Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1)	PPP1R1A IPP1	Homo sapiens (Human)	171	FUNCTION: Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.		glycogen metabolic process [GO:0005977]; intracellular signal transduction [GO:0035556]	cytoplasm [GO:0005737]	protein serine/threonine phosphatase inhibitor activity [GO:0004865]	cytoplasm [GO:0005737]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; glycogen metabolic process [GO:0005977]; intracellular signal transduction [GO:0035556]	
Q13523	reviewed	PRP4B_HUMAN	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)	PRPF4B KIAA0536 PRP4 PRP4H PRP4K	Homo sapiens (Human)	1007	FUNCTION: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.		mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; protein phosphorylation [GO:0006468]; RNA splicing [GO:0008380]	catalytic step 2 spliceosome [GO:0071013]; chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; protein phosphorylation [GO:0006468]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus.
Q13526	reviewed	PIN1_HUMAN	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1)	PIN1	Homo sapiens (Human)	163	FUNCTION: Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}.		cell cycle [GO:0007049]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of cell motility [GO:2000146]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein binding [GO:0032091]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron differentiation [GO:0030182]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein binding [GO:0032092]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein peptidyl-prolyl isomerization [GO:0000413]; protein stabilization [GO:0050821]; regulation of cytokinesis [GO:0032465]; regulation of gene expression [GO:0010468]; regulation of mitotic nuclear division [GO:0007088]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein phosphorylation [GO:0001932]; regulation of protein stability [GO:0031647]; response to hypoxia [GO:0001666]; synapse organization [GO:0050808]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; midbody [GO:0030496]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]	beta-catenin binding [GO:0008013]; cis-trans isomerase activity [GO:0016859]; cytoskeletal motor activity [GO:0003774]; GTPase activating protein binding [GO:0032794]; mitogen-activated protein kinase kinase binding [GO:0031434]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphoprotein binding [GO:0051219]; phosphoserine residue binding [GO:0050815]; phosphothreonine residue binding [GO:0050816]; tau protein binding [GO:0048156]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; midbody [GO:0030496]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; beta-catenin binding [GO:0008013]; cis-trans isomerase activity [GO:0016859]; cytoskeletal motor activity [GO:0003774]; GTPase activating protein binding [GO:0032794]; mitogen-activated protein kinase kinase binding [GO:0031434]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphoprotein binding [GO:0051219]; phosphoserine residue binding [GO:0050815]; phosphothreonine residue binding [GO:0050816]; tau protein binding [GO:0048156]; cell cycle [GO:0007049]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of cell motility [GO:2000146]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein binding [GO:0032091]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron differentiation [GO:0030182]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein binding [GO:0032092]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein peptidyl-prolyl isomerization [GO:0000413]; protein stabilization [GO:0050821]; regulation of cytokinesis [GO:0032465]; regulation of gene expression [GO:0010468]; regulation of mitotic nuclear division [GO:0007088]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein phosphorylation [GO:0001932]; regulation of protein stability [GO:0031647]; response to hypoxia [GO:0001666]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16476580, ECO:0000269|PubMed:23623683}. Nucleus speckle {ECO:0000269|PubMed:21497122}. Cytoplasm {ECO:0000269|PubMed:21497122}. Note=Colocalizes with NEK6 in the nucleus (PubMed:16476580). Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization (PubMed:21497122). {ECO:0000269|PubMed:16476580}.
Q13530	reviewed	SERC3_HUMAN	Serine incorporator 3 (Tumor differentially expressed protein 1)	SERINC3 DIFF33 TDE1 SBBI99	Homo sapiens (Human)	473	FUNCTION: Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). {ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}.		defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; L-serine biosynthetic process [GO:0006564]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	L-serine transmembrane transporter activity [GO:0015194]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; L-serine transmembrane transporter activity [GO:0015194]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; L-serine biosynthetic process [GO:0006564]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86VE9}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9QZI9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9QZI9}.; SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000305|PubMed:26416734}. Note=(Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (Probable). {ECO:0000305|PubMed:26416734}.
Q13535	reviewed	ATR_HUMAN	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)	ATR FRP1	Homo sapiens (Human)	2644	FUNCTION: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). {ECO:0000250|UniProtKB:Q9JKK8, ECO:0000269|PubMed:10597277, ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164, ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805, ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:14729973, ECO:0000269|PubMed:14742437, ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15496423, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:33848395, ECO:0000269|PubMed:9427750, ECO:0000269|PubMed:9636169, ECO:0000269|PubMed:9925639}.		cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; establishment of protein-containing complex localization to telomere [GO:0097695]; establishment of RNA localization to telomere [GO:0097694]; interstrand cross-link repair [GO:0036297]; negative regulation of DNA replication [GO:0008156]; nucleobase-containing compound metabolic process [GO:0006139]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of cellular response to heat [GO:1900034]; regulation of double-strand break repair [GO:2000779]; replication fork processing [GO:0031297]; replicative senescence [GO:0090399]; response to arsenic-containing substance [GO:0046685]; response to xenobiotic stimulus [GO:0009410]; telomere maintenance [GO:0000723]	ATR-ATRIP complex [GO:0070310]; chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; MutLalpha complex binding [GO:0032405]; MutSalpha complex binding [GO:0032407]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATR-ATRIP complex [GO:0070310]; chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; MutLalpha complex binding [GO:0032405]; MutSalpha complex binding [GO:0032407]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; establishment of protein-containing complex localization to telomere [GO:0097695]; establishment of RNA localization to telomere [GO:0097694]; interstrand cross-link repair [GO:0036297]; negative regulation of DNA replication [GO:0008156]; nucleobase-containing compound metabolic process [GO:0006139]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of cellular response to heat [GO:1900034]; regulation of double-strand break repair [GO:2000779]; replication fork processing [GO:0031297]; replicative senescence [GO:0090399]; response to arsenic-containing substance [GO:0046685]; response to xenobiotic stimulus [GO:0009410]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14871897, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:8843195}. Chromosome {ECO:0000250|UniProtKB:Q9JKK8}. Note=Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.
Q13541	reviewed	4EBP1_HUMAN	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)	EIF4EBP1	Homo sapiens (Human)	118	FUNCTION: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}.		G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; positive regulation of mitotic cell cycle [GO:0045931]; TOR signaling [GO:0031929]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	eukaryotic initiation factor 4E binding [GO:0008190]; translation initiation factor binding [GO:0031369]; translation repressor activity [GO:0030371]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic initiation factor 4E binding [GO:0008190]; translation initiation factor binding [GO:0031369]; translation repressor activity [GO:0030371]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; positive regulation of mitotic cell cycle [GO:0045931]; TOR signaling [GO:0031929]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22684010}. Nucleus {ECO:0000269|PubMed:22684010}. Note=Localization to the nucleus is unaffected by phosphorylation status. {ECO:0000250|UniProtKB:Q60876}.
Q13542	reviewed	4EBP2_HUMAN	Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)	EIF4EBP2	Homo sapiens (Human)	120	FUNCTION: Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:30765518, PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}.		insulin receptor signaling pathway [GO:0008286]; memory [GO:0007613]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of translational initiation [GO:0045947]; regulation of synaptic plasticity [GO:0048167]; social behavior [GO:0035176]; TOR signaling [GO:0031929]; translation [GO:0006412]	cytoplasm [GO:0005737]; intracellular non-membrane-bounded organelle [GO:0043232]; neuronal ribonucleoprotein granule [GO:0071598]; postsynapse [GO:0098794]	eukaryotic initiation factor 4E binding [GO:0008190]; translation repressor activity [GO:0030371]	cytoplasm [GO:0005737]; intracellular non-membrane-bounded organelle [GO:0043232]; neuronal ribonucleoprotein granule [GO:0071598]; postsynapse [GO:0098794]; eukaryotic initiation factor 4E binding [GO:0008190]; translation repressor activity [GO:0030371]; insulin receptor signaling pathway [GO:0008286]; memory [GO:0007613]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of translational initiation [GO:0045947]; regulation of synaptic plasticity [GO:0048167]; social behavior [GO:0035176]; TOR signaling [GO:0031929]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P70445}. Nucleus {ECO:0000250|UniProtKB:P70445}.
Q13546	reviewed	RIPK1_HUMAN	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)	RIPK1 RIP RIP1	Homo sapiens (Human)	671	FUNCTION: Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:32657447, PubMed:31827280, PubMed:31827281, PubMed:17703191, PubMed:24144979). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591, PubMed:15310755). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447}.		amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to tumor necrosis factor [GO:0071356]; extrinsic apoptotic signaling pathway [GO:0097191]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of necroptotic process [GO:0060546]; peptidyl-serine autophosphorylation [GO:0036289]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of miRNA processing [GO:1903800]; positive regulation of necroptotic process [GO:0060545]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of programmed cell death [GO:0043068]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; regulation of ATP:ADP antiporter activity [GO:0070926]; response to oxidative stress [GO:0006979]; response to tumor necrosis factor [GO:0034612]; ripoptosome assembly [GO:0097343]; ripoptosome assembly involved in necroptotic process [GO:1901026]; T cell apoptotic process [GO:0070231]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ripoptosome [GO:0097342]	ATP binding [GO:0005524]; death domain binding [GO:0070513]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ripoptosome [GO:0097342]; ATP binding [GO:0005524]; death domain binding [GO:0070513]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to tumor necrosis factor [GO:0071356]; extrinsic apoptotic signaling pathway [GO:0097191]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of necroptotic process [GO:0060546]; peptidyl-serine autophosphorylation [GO:0036289]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of miRNA processing [GO:1903800]; positive regulation of necroptotic process [GO:0060545]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of programmed cell death [GO:0043068]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; regulation of ATP:ADP antiporter activity [GO:0070926]; response to oxidative stress [GO:0006979]; response to tumor necrosis factor [GO:0034612]; ripoptosome assembly [GO:0097343]; ripoptosome assembly involved in necroptotic process [GO:1901026]; T cell apoptotic process [GO:0070231]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q60855}. Cell membrane {ECO:0000250|UniProtKB:Q9ZUF4}.
Q13547	reviewed	HDAC1_HUMAN	Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)	HDAC1 RPD3L1	Homo sapiens (Human)	482	FUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Also functions as deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3 and TSHZ3 (PubMed:12837748, PubMed:16478997, PubMed:17996965, PubMed:19343227). Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (PubMed:28497810). {ECO:0000250|UniProtKB:O09106, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666}.		cellular response to platelet-derived growth factor stimulus [GO:0036120]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; DNA methylation-dependent heterochromatin formation [GO:0006346]; embryonic digit morphogenesis [GO:0042733]; endoderm development [GO:0007492]; epidermal cell differentiation [GO:0009913]; eyelid development in camera-type eye [GO:0061029]; fungiform papilla formation [GO:0061198]; hair follicle placode formation [GO:0060789]; hippocampus development [GO:0021766]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; regulation of amyloid-beta clearance [GO:1900221]; regulation of cell fate specification [GO:0042659]; regulation of endopeptidase activity [GO:0052548]; regulation of stem cell differentiation [GO:2000736]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; histone deacetylase complex [GO:0000118]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; Sin3 complex [GO:0016580]; transcription repressor complex [GO:0017053]	core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; Krueppel-associated box domain binding [GO:0035851]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; histone deacetylase complex [GO:0000118]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; Sin3 complex [GO:0016580]; transcription repressor complex [GO:0017053]; core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; Krueppel-associated box domain binding [GO:0035851]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; DNA methylation-dependent heterochromatin formation [GO:0006346]; embryonic digit morphogenesis [GO:0042733]; endoderm development [GO:0007492]; epidermal cell differentiation [GO:0009913]; eyelid development in camera-type eye [GO:0061029]; fungiform papilla formation [GO:0061198]; hair follicle placode formation [GO:0060789]; hippocampus development [GO:0021766]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; regulation of amyloid-beta clearance [GO:1900221]; regulation of cell fate specification [GO:0042659]; regulation of endopeptidase activity [GO:0052548]; regulation of stem cell differentiation [GO:2000736]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10846170, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}.
Q13554	reviewed	KCC2B_HUMAN	Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)	CAMK2B CAM2 CAMK2 CAMKB	Homo sapiens (Human)	666	FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}.		cell differentiation [GO:0030154]; nervous system development [GO:0007399]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of neuron projection development [GO:0010976]; positive regulation of synapse maturation [GO:0090129]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of calcium ion transport [GO:0051924]; regulation of dendritic spine development [GO:0060998]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of neuron migration [GO:2001222]; regulation of skeletal muscle adaptation [GO:0014733]; regulation of synapse structural plasticity [GO:0051823]; signal transduction [GO:0007165]	calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; microtubule organizing center [GO:0005815]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum membrane [GO:0033017]; synapse [GO:0045202]	actin binding [GO:0003779]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]	calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; microtubule organizing center [GO:0005815]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum membrane [GO:0033017]; synapse [GO:0045202]; actin binding [GO:0003779]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of neuron projection development [GO:0010976]; positive regulation of synapse maturation [GO:0090129]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of calcium ion transport [GO:0051924]; regulation of dendritic spine development [GO:0060998]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of neuron migration [GO:2001222]; regulation of skeletal muscle adaptation [GO:0014733]; regulation of synapse structural plasticity [GO:0051823]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21529938}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:21529938}; Peripheral membrane protein {ECO:0000269|PubMed:21529938}; Cytoplasmic side {ECO:0000269|PubMed:21529938}. Synapse {ECO:0000250|UniProtKB:P08413}. Note=In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.
Q13555	reviewed	KCC2G_HUMAN	Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17)	CAMK2G CAMK CAMK-II CAMKG	Homo sapiens (Human)	558	FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}.		cell differentiation [GO:0030154]; insulin secretion [GO:0030073]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; regulation of calcium ion transport [GO:0051924]; regulation of neuron projection development [GO:0010975]; regulation of skeletal muscle adaptation [GO:0014733]	calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum membrane [GO:0033017]	ATP binding [GO:0005524]; calcium-dependent protein serine/threonine phosphatase activity [GO:0004723]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]	calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum membrane [GO:0033017]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine phosphatase activity [GO:0004723]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; cell differentiation [GO:0030154]; insulin secretion [GO:0030073]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; regulation of calcium ion transport [GO:0051924]; regulation of neuron projection development [GO:0010975]; regulation of skeletal muscle adaptation [GO:0014733]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q13557	reviewed	KCC2D_HUMAN	Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)	CAMK2D CAMKD	Homo sapiens (Human)	499	FUNCTION: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}.	MISCELLANEOUS: Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy in PubMed:10189359.	cardiac muscle cell contraction [GO:0086003]; cellular response to calcium ion [GO:0071277]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of sodium ion transmembrane transport [GO:1902306]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cell growth [GO:0001558]; regulation of cellular localization [GO:0060341]; regulation of heart contraction [GO:0008016]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane depolarization [GO:0003254]; regulation of relaxation of cardiac muscle [GO:1901897]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of the force of heart contraction [GO:0002026]; regulation of transcription by RNA polymerase II [GO:0006357]; relaxation of cardiac muscle [GO:0055119]	calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; sodium channel inhibitor activity [GO:0019871]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325]	calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; sodium channel inhibitor activity [GO:0019871]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325]; cardiac muscle cell contraction [GO:0086003]; cellular response to calcium ion [GO:0071277]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of sodium ion transmembrane transport [GO:1902306]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cell growth [GO:0001558]; regulation of cellular localization [GO:0060341]; regulation of heart contraction [GO:0008016]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane depolarization [GO:0003254]; regulation of relaxation of cardiac muscle [GO:1901897]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of the force of heart contraction [GO:0002026]; regulation of transcription by RNA polymerase II [GO:0006357]; relaxation of cardiac muscle [GO:0055119]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Sarcoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q13561	reviewed	DCTN2_HUMAN	Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin)	DCTN2 DCTN50	Homo sapiens (Human)	401	FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}.		melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; protein localization to centrosome [GO:0071539]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; dynein complex [GO:0030286]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; vesicle [GO:0031982]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; spectrin binding [GO:0030507]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; dynein complex [GO:0030286]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; vesicle [GO:0031982]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; spectrin binding [GO:0030507]; melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; protein localization to centrosome [GO:0071539]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:8647893}. Membrane {ECO:0000269|PubMed:8647893}; Peripheral membrane protein {ECO:0000269|PubMed:8647893}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0A5G2QD80}.
Q13562	reviewed	NDF1_HUMAN	Neurogenic differentiation factor 1 (NeuroD) (NeuroD1) (Class A basic helix-loop-helix protein 3) (bHLHa3)	NEUROD1 BHLHA3 NEUROD	Homo sapiens (Human)	356	FUNCTION: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q60867}.		amacrine cell differentiation [GO:0035881]; anterior/posterior pattern specification [GO:0009952]; axon development [GO:0061564]; cellular response to glucose stimulus [GO:0071333]; cerebellum development [GO:0021549]; dentate gyrus development [GO:0021542]; embryonic organ morphogenesis [GO:0048562]; endocrine pancreas development [GO:0031018]; enteroendocrine cell differentiation [GO:0035883]; glucose homeostasis [GO:0042593]; inner ear development [GO:0048839]; insulin secretion [GO:0030073]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; neurogenesis [GO:0022008]; nitric oxide mediated signal transduction [GO:0007263]; nucleocytoplasmic transport [GO:0006913]; pancreatic A cell fate commitment [GO:0003326]; pancreatic PP cell fate commitment [GO:0003329]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of insulin secretion [GO:0050796]; regulation of intestinal epithelial structure maintenance [GO:0060730]; response to glucose [GO:0009749]; response to xenobiotic stimulus [GO:0009410]; sensory organ development [GO:0007423]; signal transduction involved in regulation of gene expression [GO:0023019]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein heterodimerization activity [GO:0046982]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein heterodimerization activity [GO:0046982]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; amacrine cell differentiation [GO:0035881]; anterior/posterior pattern specification [GO:0009952]; axon development [GO:0061564]; cellular response to glucose stimulus [GO:0071333]; cerebellum development [GO:0021549]; dentate gyrus development [GO:0021542]; embryonic organ morphogenesis [GO:0048562]; endocrine pancreas development [GO:0031018]; enteroendocrine cell differentiation [GO:0035883]; glucose homeostasis [GO:0042593]; inner ear development [GO:0048839]; insulin secretion [GO:0030073]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; neurogenesis [GO:0022008]; nitric oxide mediated signal transduction [GO:0007263]; nucleocytoplasmic transport [GO:0006913]; pancreatic A cell fate commitment [GO:0003326]; pancreatic PP cell fate commitment [GO:0003329]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of insulin secretion [GO:0050796]; regulation of intestinal epithelial structure maintenance [GO:0060730]; response to glucose [GO:0009749]; response to xenobiotic stimulus [GO:0009410]; sensory organ development [GO:0007423]; signal transduction involved in regulation of gene expression [GO:0023019]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:14752053}. Note=In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation (By similarity). Colocalizes with NR0B2 in the nucleus. {ECO:0000250}.
Q13563	reviewed	PKD2_HUMAN	Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2)	PKD2 TRPP2	Homo sapiens (Human)	968	FUNCTION: Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Can also form a functional, homotetrameric ion channel (PubMed:29899465). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:16551655, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:20881056, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:29899465, ECO:0000305}.	MISCELLANEOUS: The mechanisms that govern channel opening are complex and still under debate; heterologous expression of PKD2 by itself or together with PKD1 gives rise to very low or undetectable spontaneous ion channel activity, in spite of its presence at the cell membrane. {ECO:0000269|PubMed:19556541, ECO:0000269|PubMed:27768895}.; MISCELLANEOUS: [Isoform 5]: Minor isoform. {ECO:0000305}.	aorta development [GO:0035904]; branching involved in ureteric bud morphogenesis [GO:0001658]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell-cell signaling by wnt [GO:0198738]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to osmotic stress [GO:0071470]; cellular response to reactive oxygen species [GO:0034614]; centrosome duplication [GO:0051298]; cilium organization [GO:0044782]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; embryonic placenta development [GO:0001892]; establishment of localization in cell [GO:0051649]; heart development [GO:0007507]; heart looping [GO:0001947]; inorganic cation transmembrane transport [GO:0098662]; intracellular calcium ion homeostasis [GO:0006874]; liver development [GO:0001889]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric cortex development [GO:0072214]; metanephric cortical collecting duct development [GO:0072219]; metanephric distal tubule development [GO:0072235]; metanephric mesenchyme development [GO:0072075]; metanephric part of ureteric bud development [GO:0035502]; metanephric S-shaped body morphogenesis [GO:0072284]; metanephric smooth muscle tissue development [GO:0072208]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neural tube development [GO:0021915]; placenta blood vessel development [GO:0060674]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of transcription by RNA polymerase II [GO:0045944]; potassium ion transmembrane transport [GO:0071805]; protein heterotetramerization [GO:0051290]; protein homotetramerization [GO:0051289]; protein tetramerization [GO:0051262]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of calcium ion import [GO:0090279]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; release of sequestered calcium ion into cytosol [GO:0051209]; renal artery morphogenesis [GO:0061441]; renal tubule morphogenesis [GO:0061333]; sodium ion transmembrane transport [GO:0035725]; spinal cord development [GO:0021510]; Wnt signaling pathway [GO:0016055]	basal cortex [GO:0045180]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cation channel complex [GO:0034703]; cell-cell junction [GO:0005911]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; polycystin complex [GO:0002133]	actinin binding [GO:0042805]; ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; cytoskeletal protein binding [GO:0008092]; HLH domain binding [GO:0043398]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; outward rectifier potassium channel activity [GO:0015271]; phosphoprotein binding [GO:0051219]; potassium channel activity [GO:0005267]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]	basal cortex [GO:0045180]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cation channel complex [GO:0034703]; cell-cell junction [GO:0005911]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; polycystin complex [GO:0002133]; actinin binding [GO:0042805]; ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; cytoskeletal protein binding [GO:0008092]; HLH domain binding [GO:0043398]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; outward rectifier potassium channel activity [GO:0015271]; phosphoprotein binding [GO:0051219]; potassium channel activity [GO:0005267]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]; aorta development [GO:0035904]; branching involved in ureteric bud morphogenesis [GO:0001658]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell-cell signaling by wnt [GO:0198738]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to osmotic stress [GO:0071470]; cellular response to reactive oxygen species [GO:0034614]; centrosome duplication [GO:0051298]; cilium organization [GO:0044782]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; embryonic placenta development [GO:0001892]; establishment of localization in cell [GO:0051649]; heart development [GO:0007507]; heart looping [GO:0001947]; inorganic cation transmembrane transport [GO:0098662]; intracellular calcium ion homeostasis [GO:0006874]; liver development [GO:0001889]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric cortex development [GO:0072214]; metanephric cortical collecting duct development [GO:0072219]; metanephric distal tubule development [GO:0072235]; metanephric mesenchyme development [GO:0072075]; metanephric part of ureteric bud development [GO:0035502]; metanephric S-shaped body morphogenesis [GO:0072284]; metanephric smooth muscle tissue development [GO:0072208]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neural tube development [GO:0021915]; placenta blood vessel development [GO:0060674]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of transcription by RNA polymerase II [GO:0045944]; potassium ion transmembrane transport [GO:0071805]; protein heterotetramerization [GO:0051290]; protein homotetramerization [GO:0051289]; protein tetramerization [GO:0051262]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of calcium ion import [GO:0090279]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; release of sequestered calcium ion into cytosol [GO:0051209]; renal artery morphogenesis [GO:0061441]; renal tubule morphogenesis [GO:0061333]; sodium ion transmembrane transport [GO:0035725]; spinal cord development [GO:0021510]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:20881056, ECO:0000269|PubMed:27259053}; Multi-pass membrane protein {ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:30093605}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10760273, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:20881056, ECO:0000269|PubMed:28092368, ECO:0000305|PubMed:10913159}; Multi-pass membrane protein {ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:30093605}. Cell membrane {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:19556541, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:27259053, ECO:0000269|PubMed:28092368, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:30093605}; Multi-pass membrane protein {ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:30093605}. Basolateral cell membrane {ECO:0000269|PubMed:10770959}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10770959}. Golgi apparatus {ECO:0000250|UniProtKB:O35245}. Note=PKD2 localization to the plasma and ciliary membranes requires PKD1. PKD1:PKD2 interaction is required to reach the Golgi apparatus form endoplasmic reticulum and then traffic to the cilia (By similarity). Retained in the endoplasmic reticulum by interaction with PACS1 and PACS2 (PubMed:15692563). Detected on kidney tubule basolateral membranes and basal cytoplasmic vesicles (PubMed:10770959). Cell surface and cilium localization requires GANAB (PubMed:27259053). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:27259053}.
Q13564	reviewed	ULA1_HUMAN	NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)	NAE1 APPBP1 HPP1	Homo sapiens (Human)	534	FUNCTION: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:10722740, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:36608681}.	MISCELLANEOUS: NAE1 and UBA3 correspond to the N-terminal and the C-terminal part of yeast UBA3. In yeast the two subunits form a single polypeptide chain.	DNA damage response [GO:0006974]; mitotic DNA replication checkpoint signaling [GO:0033314]; neuron apoptotic process [GO:0051402]; protein neddylation [GO:0045116]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of neuron apoptotic process [GO:0043523]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	NEDD8 activating enzyme activity [GO:0019781]; protein heterodimerization activity [GO:0046982]; ubiquitin activating enzyme activity [GO:0004839]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; NEDD8 activating enzyme activity [GO:0019781]; protein heterodimerization activity [GO:0046982]; ubiquitin activating enzyme activity [GO:0004839]; ubiquitin protein ligase binding [GO:0031625]; DNA damage response [GO:0006974]; mitotic DNA replication checkpoint signaling [GO:0033314]; neuron apoptotic process [GO:0051402]; protein neddylation [GO:0045116]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of neuron apoptotic process [GO:0043523]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14557245}. Note=Colocalizes with APP in lipid rafts.
Q13568	reviewed	IRF5_HUMAN	Interferon regulatory factor 5 (IRF-5)	IRF5	Homo sapiens (Human)	498	FUNCTION: Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}.		cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; regulation of transcription by RNA polymerase II [GO:0006357]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; regulation of transcription by RNA polymerase II [GO:0006357]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12138184, ECO:0000269|PubMed:15556946, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418}. Nucleus {ECO:0000269|PubMed:12138184, ECO:0000269|PubMed:15556946, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418}. Note=Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation, translocates to the nucleus. {ECO:0000269|PubMed:12138184, ECO:0000269|PubMed:15556946, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418}.
Q13569	reviewed	TDG_HUMAN	G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (Thymine-DNA glycosylase) (hTDG)	TDG	Homo sapiens (Human)	410	FUNCTION: DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. {ECO:0000269|PubMed:21862836, ECO:0000269|PubMed:22327402, ECO:0000269|PubMed:22573813, ECO:0000269|PubMed:22962365, ECO:0000269|PubMed:8127859, ECO:0000269|PubMed:8407958, ECO:0000269|PubMed:8662714}.		base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; depyrimidination [GO:0045008]; DNA demethylation [GO:0080111]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of embryonic development [GO:0045995]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]	ATP binding [GO:0005524]; chloride ion binding [GO:0031404]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; G/T mismatch-specific thymine-DNA glycosylase activity [GO:0141016]; G/U mismatch-specific uracil-DNA glycosylase activity [GO:0043739]; magnesium ion binding [GO:0000287]; mismatched DNA binding [GO:0030983]; nucleic acid binding [GO:0003676]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; protein self-association [GO:0043621]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; sodium ion binding [GO:0031402]; SUMO binding [GO:0032183]; transcription coregulator activity [GO:0003712]; uracil DNA N-glycosylase activity [GO:0004844]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; ATP binding [GO:0005524]; chloride ion binding [GO:0031404]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; G/T mismatch-specific thymine-DNA glycosylase activity [GO:0141016]; G/U mismatch-specific uracil-DNA glycosylase activity [GO:0043739]; magnesium ion binding [GO:0000287]; mismatched DNA binding [GO:0030983]; nucleic acid binding [GO:0003676]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; protein self-association [GO:0043621]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; sodium ion binding [GO:0031402]; SUMO binding [GO:0032183]; transcription coregulator activity [GO:0003712]; uracil DNA N-glycosylase activity [GO:0004844]; base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; depyrimidination [GO:0045008]; DNA demethylation [GO:0080111]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of embryonic development [GO:0045995]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8662714}.
Q13571	reviewed	LAPM5_HUMAN	Lysosomal-associated transmembrane protein 5 (Lysosomal-associated multitransmembrane protein 5) (Retinoic acid-inducible E3 protein)	LAPTM5 KIAA0085	Homo sapiens (Human)	262	FUNCTION: May have a special functional role during embryogenesis and in adult hematopoietic cells. {ECO:0000269|PubMed:8661146}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; defense response to tumor cell [GO:0002357]; Golgi to lysosome transport [GO:0090160]; induction of programmed cell death [GO:0012502]; intracellular protein transport [GO:0006886]; negative regulation of autophagic cell death [GO:1904093]; negative regulation of B cell activation [GO:0050869]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of type II interferon production [GO:0032689]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of lysosomal membrane permeability [GO:0097214]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of receptor catabolic process [GO:2000646]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein targeting to lysosome [GO:0006622]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; transport vesicle [GO:0030133]	protein sequestering activity [GO:0140311]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-dependent protein binding [GO:0140036]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; transport vesicle [GO:0030133]; protein sequestering activity [GO:0140311]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-dependent protein binding [GO:0140036]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; defense response to tumor cell [GO:0002357]; Golgi to lysosome transport [GO:0090160]; induction of programmed cell death [GO:0012502]; intracellular protein transport [GO:0006886]; negative regulation of autophagic cell death [GO:1904093]; negative regulation of B cell activation [GO:0050869]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of type II interferon production [GO:0032689]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of lysosomal membrane permeability [GO:0097214]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of receptor catabolic process [GO:2000646]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein targeting to lysosome [GO:0006622]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:8661146}; Multi-pass membrane protein {ECO:0000269|PubMed:8661146}.
Q13572	reviewed	ITPK1_HUMAN	Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Inositol 1,3,4-trisphosphate 5/6-kinase) (Inositol-triphosphate 5/6-kinase) (Ins(1,3,4)P(3) 5/6-kinase) (EC 2.7.1.159)	ITPK1	Homo sapiens (Human)	414	FUNCTION: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 (PubMed:11042108, PubMed:8662638). Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5 (PubMed:11042108). This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway (PubMed:11042108, PubMed:8662638). Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4 (PubMed:17616525, PubMed:11909533). May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium (PubMed:11909533). Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed:12925536, PubMed:17616525). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:17616525). {ECO:0000269|PubMed:11042108, ECO:0000269|PubMed:11909533, ECO:0000269|PubMed:12925536, ECO:0000269|PubMed:17616525, ECO:0000269|PubMed:8662638}.		blood coagulation [GO:0007596]; inositol trisphosphate metabolic process [GO:0032957]; necroptotic process [GO:0070266]; neural tube development [GO:0021915]; phosphorylation [GO:0016310]; signal transduction [GO:0007165]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]	ATP binding [GO:0005524]; catalytic activity [GO:0003824]; hydrolase activity [GO:0016787]; inositol tetrakisphosphate 1-kinase activity [GO:0047325]; inositol tetrakisphosphate 6-kinase activity [GO:0000825]; inositol-1,3,4-trisphosphate 5-kinase activity [GO:0052726]; inositol-1,3,4-trisphosphate 6-kinase activity [GO:0052725]; isomerase activity [GO:0016853]; magnesium ion binding [GO:0000287]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; ATP binding [GO:0005524]; catalytic activity [GO:0003824]; hydrolase activity [GO:0016787]; inositol tetrakisphosphate 1-kinase activity [GO:0047325]; inositol tetrakisphosphate 6-kinase activity [GO:0000825]; inositol-1,3,4-trisphosphate 5-kinase activity [GO:0052726]; inositol-1,3,4-trisphosphate 6-kinase activity [GO:0052725]; isomerase activity [GO:0016853]; magnesium ion binding [GO:0000287]; blood coagulation [GO:0007596]; inositol trisphosphate metabolic process [GO:0032957]; necroptotic process [GO:0070266]; neural tube development [GO:0021915]; phosphorylation [GO:0016310]; signal transduction [GO:0007165]	
Q13573	reviewed	SNW1_HUMAN	SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein)	SNW1 SKIIP SKIP	Homo sapiens (Human)	536	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}.		cellular response to retinoic acid [GO:0071300]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vitamin D receptor signaling pathway [GO:0070562]; retinoic acid receptor signaling pathway [GO:0048384]	catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]	enzyme binding [GO:0019899]; Notch binding [GO:0005112]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor binding [GO:0016922]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear vitamin D receptor binding [GO:0042809]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]; enzyme binding [GO:0019899]; Notch binding [GO:0005112]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor binding [GO:0016922]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear vitamin D receptor binding [GO:0042809]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; cellular response to retinoic acid [GO:0071300]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vitamin D receptor signaling pathway [GO:0070562]; retinoic acid receptor signaling pathway [GO:0048384]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
Q13574	reviewed	DGKZ_HUMAN	Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta)	DGKZ DAGK6	Homo sapiens (Human)	928	FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:9159104, PubMed:19744926, PubMed:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q80UP3, ECO:0000269|PubMed:15157668, ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:18004883, ECO:0000269|PubMed:19744926, ECO:0000269|PubMed:22108654, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:23949095, ECO:0000269|PubMed:9159104, ECO:0000305|PubMed:8626588}.; FUNCTION: [Isoform 1]: Regulates RASGRP1 activity. {ECO:0000269|PubMed:11257115}.; FUNCTION: [Isoform 2]: Does not regulate RASGRP1 activity. {ECO:0000269|PubMed:11257115}.	MISCELLANEOUS: [Isoform 2]: Minor isoform.; MISCELLANEOUS: [Isoform 1]: Major isoform. {ECO:0000305}.	cell migration [GO:0016477]; diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of T cell receptor signaling pathway [GO:0050860]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0090216]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of synaptic transmission, glutamatergic [GO:0051966]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; kinase activity [GO:0016301]; lipid kinase activity [GO:0001727]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; kinase activity [GO:0016301]; lipid kinase activity [GO:0001727]; metal ion binding [GO:0046872]; cell migration [GO:0016477]; diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of T cell receptor signaling pathway [GO:0050860]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0090216]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of synaptic transmission, glutamatergic [GO:0051966]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11257115, ECO:0000269|PubMed:15157668, ECO:0000269|PubMed:9159104, ECO:0000269|PubMed:9716136}. Cytoplasm, cytosol {ECO:0000269|PubMed:11257115, ECO:0000269|PubMed:22627129}. Cell membrane {ECO:0000269|PubMed:11257115}. Cell projection, lamellipodium {ECO:0000269|PubMed:15157668}.
Q13576	reviewed	IQGA2_HUMAN	Ras GTPase-activating-like protein IQGAP2	IQGAP2	Homo sapiens (Human)	1575	FUNCTION: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.		Arp2/3 complex-mediated actin nucleation [GO:0034314]; mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; thrombin-activated receptor signaling pathway [GO:0070493]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase inhibitor activity [GO:0005095]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase inhibitor activity [GO:0005095]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; small GTPase binding [GO:0031267]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; thrombin-activated receptor signaling pathway [GO:0070493]	
Q13585	reviewed	MTR1L_HUMAN	Melatonin-related receptor (G protein-coupled receptor 50) (H9)	GPR50	Homo sapiens (Human)	617	FUNCTION: Does not bind melatonin.		cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]	nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; melatonin receptor activity [GO:0008502]	nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; melatonin receptor activity [GO:0008502]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q13586	reviewed	STIM1_HUMAN	Stromal interaction molecule 1	STIM1 GOK	Homo sapiens (Human)	685	FUNCTION: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555, PubMed:28219928). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (PubMed:26322679). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928}.	MISCELLANEOUS: Transfection of STIM1 into cells derived from a rhabdoid tumor and from a rhabdomyosarcoma that do not express detectable levels of STIM1 can induce cell death, suggesting a possible role in the control of rhabdomyosarcomas and rhabdoid tumors. {ECO:0000269|PubMed:9377559}.	activation of store-operated calcium channel activity [GO:0032237]; detection of calcium ion [GO:0005513]; enamel mineralization [GO:0070166]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of angiogenesis [GO:0045766]; regulation of calcium ion transport [GO:0051924]; regulation of store-operated calcium entry [GO:2001256]; store-operated calcium entry [GO:0002115]	cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; sarcoplasmic reticulum membrane [GO:0033017]	calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; microtubule plus-end binding [GO:0051010]; protease binding [GO:0002020]	cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; sarcoplasmic reticulum membrane [GO:0033017]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; microtubule plus-end binding [GO:0051010]; protease binding [GO:0002020]; activation of store-operated calcium channel activity [GO:0032237]; detection of calcium ion [GO:0005513]; enamel mineralization [GO:0070166]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of angiogenesis [GO:0045766]; regulation of calcium ion transport [GO:0051924]; regulation of store-operated calcium entry [GO:2001256]; store-operated calcium entry [GO:0002115]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:11004585, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:27185316, ECO:0000269|PubMed:28219928}. Endoplasmic reticulum membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:27185316}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19632184}. Sarcoplasmic reticulum {ECO:0000269|PubMed:25326555}. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane (PubMed:19249086, PubMed:16005298, PubMed:16208375, PubMed:18854159). Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Colocalizes with ORAI1 at the cell membrane (PubMed:27185316). Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316). {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:27185316}.
Q13588	reviewed	GRAP_HUMAN	GRB2-related adapter protein	GRAP	Homo sapiens (Human)	217	FUNCTION: Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing (PubMed:30610177). {ECO:0000269|PubMed:30610177}.		cell-cell signaling [GO:0007267]; Ras protein signal transduction [GO:0007265]; regulation of MAPK cascade [GO:0043408]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784]; cell-cell signaling [GO:0007267]; Ras protein signal transduction [GO:0007265]; regulation of MAPK cascade [GO:0043408]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q08012}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q08012}. Synapse {ECO:0000250|UniProtKB:Q08012}. Note=Localizes at the presynaptic terminal. {ECO:0000250|UniProtKB:Q08012}.
Q13591	reviewed	SEM5A_HUMAN	Semaphorin-5A (Semaphorin-F) (Sema F)	SEMA5A SEMAF	Homo sapiens (Human)	1074	FUNCTION: Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. {ECO:0000250, ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:19850054, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.		axon extension [GO:0048675]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell signaling [GO:0007267]; diencephalon development [GO:0021536]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; negative regulation of endothelial cell apoptotic process [GO:2000352]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive chemotaxis [GO:0050918]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; semaphorin-plexin signaling pathway [GO:0071526]; signal clustering [GO:1990256]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	chemorepellent activity [GO:0045499]; chondroitin sulfate proteoglycan binding [GO:0035373]; heparan sulfate proteoglycan binding [GO:0043395]; semaphorin receptor binding [GO:0030215]; syndecan binding [GO:0045545]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; chemorepellent activity [GO:0045499]; chondroitin sulfate proteoglycan binding [GO:0035373]; heparan sulfate proteoglycan binding [GO:0043395]; semaphorin receptor binding [GO:0030215]; syndecan binding [GO:0045545]; axon extension [GO:0048675]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell signaling [GO:0007267]; diencephalon development [GO:0021536]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; negative regulation of endothelial cell apoptotic process [GO:2000352]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive chemotaxis [GO:0050918]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; semaphorin-plexin signaling pathway [GO:0071526]; signal clustering [GO:1990256]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q13595	reviewed	TRA2A_HUMAN	Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A)	TRA2A	Homo sapiens (Human)	282	FUNCTION: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}.		mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]	intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9546399}.
Q13596	reviewed	SNX1_HUMAN	Sorting nexin-1	SNX1	Homo sapiens (Human)	522	FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}.	MISCELLANEOUS: Binds phosphatidylinositol 3-phosphate (PtdIns-(3)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2) in liposome-based assays. Can bind PtdIns(3,4,5)P3 in protein:lipid overlay assays, but not in liposome-based assays.	early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886]; lamellipodium morphogenesis [GO:0072673]; receptor internalization [GO:0031623]; retrograde transport, endosome to Golgi [GO:0042147]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; lysosome [GO:0005764]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; vesicle [GO:0031982]	cadherin binding [GO:0045296]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transferrin receptor binding [GO:1990459]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; lysosome [GO:0005764]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transferrin receptor binding [GO:1990459]; early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886]; lamellipodium morphogenesis [GO:0072673]; receptor internalization [GO:0031623]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:22431521}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalizes with DNAJC13 and Shiginella dysenteria toxin stxB on early endosomes (PubMed:19874558). Colocalized with F-actin at the leading edge of lamellipodia in a KALRN-dependent manner (PubMed:20604901). {ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:20604901}.
Q13601	reviewed	KRR1_HUMAN	KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1)	KRR1 HRB2	Homo sapiens (Human)	381	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}.		ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:34516797}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7724608}. Cytoplasm {ECO:0000269|PubMed:7724608}. Note=(Microbial infection) Translocates from cytoplasm to nucleus after exposure to HIV-1 virus or HIV-1 protein VPR or induction by hydrocortisone and dexamethasone in the absence of HIV-1 protein VPR. {ECO:0000269|PubMed:7724608}.
Q13608	reviewed	PEX6_HUMAN	Peroxisomal ATPase PEX6 (EC 3.6.4.-) (Peroxin-6) (Peroxisomal biogenesis factor 6) (Peroxisomal-type ATPase 1) (Peroxisome assembly factor 2) (PAF-2)	PEX6 PXAAA1	Homo sapiens (Human)	980	FUNCTION: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:16314507, PubMed:16854980, PubMed:21362118, PubMed:29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29884772). {ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118, ECO:0000269|PubMed:29884772}.		peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, translocation [GO:0016561]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625]; protein unfolding [GO:0043335]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; photoreceptor cell cilium [GO:0097733]; photoreceptor outer segment [GO:0001750]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein transporter activity [GO:0140318]; protein-containing complex binding [GO:0044877]; ubiquitin-dependent protein binding [GO:0140036]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; photoreceptor cell cilium [GO:0097733]; photoreceptor outer segment [GO:0001750]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein transporter activity [GO:0140318]; protein-containing complex binding [GO:0044877]; ubiquitin-dependent protein binding [GO:0140036]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, translocation [GO:0016561]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625]; protein unfolding [GO:0043335]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16854980}. Peroxisome membrane {ECO:0000269|PubMed:11355018, ECO:0000269|PubMed:12717447, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:26593283}. Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes (PubMed:12717447, PubMed:16854980). Localized at the base of the outer segment of photoreceptor cells (PubMed:26593283). {ECO:0000269|PubMed:12717447, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:26593283}.
Q13609	reviewed	DNSL3_HUMAN	Deoxyribonuclease gamma (DNase gamma) (EC 3.1.21.-) (DNase I homolog protein DHP2) (Deoxyribonuclease I-like 3) (DNase I-like 3) (Liver and spleen DNase) (LS-DNase) (LSD)	DNASE1L3 DHP2 DNAS1L3	Homo sapiens (Human)	305	FUNCTION: Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA (PubMed:9070308, PubMed:9714828, PubMed:14646506, PubMed:10807908, PubMed:27293190). Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis (PubMed:23229555, PubMed:24312463). The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (By similarity). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PubMed:27293190). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). {ECO:0000250|UniProtKB:O55070, ECO:0000250|UniProtKB:O89107, ECO:0000269|PubMed:10807908, ECO:0000269|PubMed:14646506, ECO:0000269|PubMed:23229555, ECO:0000269|PubMed:24312463, ECO:0000269|PubMed:27293190, ECO:0000269|PubMed:9070308, ECO:0000269|PubMed:9714828}.		apoptotic DNA fragmentation [GO:0006309]; DNA metabolic process [GO:0006259]; neutrophil activation involved in immune response [GO:0002283]; programmed cell death involved in cell development [GO:0010623]; regulation of acute inflammatory response [GO:0002673]; regulation of neutrophil mediated cytotoxicity [GO:0070948]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]; DNA nuclease activity [GO:0004536]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]; DNA nuclease activity [GO:0004536]; apoptotic DNA fragmentation [GO:0006309]; DNA metabolic process [GO:0006259]; neutrophil activation involved in immune response [GO:0002283]; programmed cell death involved in cell development [GO:0010623]; regulation of acute inflammatory response [GO:0002673]; regulation of neutrophil mediated cytotoxicity [GO:0070948]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11141064, ECO:0000269|PubMed:23229555}. Endoplasmic reticulum {ECO:0000269|PubMed:23229555}. Secreted {ECO:0000269|PubMed:9714828}. Note=Translocates from the endoplasmic reticulum to the nucleus during apoptosis (PubMed:23229555). Contradictory reports exist about the subcellular localization under normal physiological conditions. Under conditions of cell death, may diffuse and/or be actively transported to the nucleus. {ECO:0000269|PubMed:23229555, ECO:0000305}.
Q13610	reviewed	PWP1_HUMAN	Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502)	PWP1	Homo sapiens (Human)	501	FUNCTION: Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309). {ECO:0000269|PubMed:29065309}.		DNA-templated transcription [GO:0006351]; negative regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033140]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; rRNA processing [GO:0006364]	chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleus [GO:0005634]	H4K20me3 modified histone binding [GO:1990889]; histone chaperone activity [GO:0140713]	chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleus [GO:0005634]; H4K20me3 modified histone binding [GO:1990889]; histone chaperone activity [GO:0140713]; DNA-templated transcription [GO:0006351]; negative regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033140]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7828893}. Nucleus, nucleolus {ECO:0000269|PubMed:29065309}. Chromosome {ECO:0000269|PubMed:29065309}. Note=Associates with chromatin regions of rDNA. {ECO:0000269|PubMed:29065309}.
Q13613	reviewed	MTMR1_HUMAN	Myotubularin-related protein 1 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)	MTMR1	Homo sapiens (Human)	665	FUNCTION: Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:11733541, PubMed:27018598). Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown by PubMed:27018598, while PubMed:11733541 find no activity with this substrate. {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:27018598}.		phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein homodimerization activity [GO:0042803]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Z2C4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z2C4}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z2C4}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z2C4}.
Q13614	reviewed	MTMR2_HUMAN	Myotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)	MTMR2 KIAA1073	Homo sapiens (Human)	643	FUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11733541, PubMed:12668758, PubMed:21372139, PubMed:14690594). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (By similarity). Stabilizes SBF2/MTMR13 at the membranes (By similarity). Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity). {ECO:0000250|UniProtKB:Q9Z2D1, ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:14690594, ECO:0000269|PubMed:21372139}.		dendritic spine maintenance [GO:0097062]; myelin assembly [GO:0032288]; negative regulation of endocytosis [GO:0045806]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of myelination [GO:0031642]; negative regulation of receptor catabolic process [GO:2000645]; negative regulation of receptor internalization [GO:0002091]; neuron development [GO:0048666]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of early endosome to late endosome transport [GO:2000643]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; vacuolar membrane [GO:0005774]	identical protein binding [GO:0042802]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; vacuolar membrane [GO:0005774]; identical protein binding [GO:0042802]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; dendritic spine maintenance [GO:0097062]; myelin assembly [GO:0032288]; negative regulation of endocytosis [GO:0045806]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of myelination [GO:0031642]; negative regulation of receptor catabolic process [GO:2000645]; negative regulation of receptor internalization [GO:0002091]; neuron development [GO:0048666]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of early endosome to late endosome transport [GO:2000643]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:15998640}. Early endosome membrane {ECO:0000269|PubMed:15998640, ECO:0000269|PubMed:21372139}; Peripheral membrane protein {ECO:0000269|PubMed:15998640, ECO:0000269|PubMed:21372139}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12668758}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2D1}. Endosome membrane {ECO:0000250|UniProtKB:Q9Z2D1}; Peripheral membrane protein {ECO:0000305}. Note=Partly associated with membranes (PubMed:12668758, PubMed:15998640, PubMed:21372139). Localizes to vacuoles in hypo-osmotic conditions (By similarity). {ECO:0000250|UniProtKB:Q9Z2D1, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:15998640, ECO:0000269|PubMed:21372139}.
Q13615	reviewed	MTMR3_HUMAN	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) (Zinc finger FYVE domain-containing protein 10)	MTMR3 KIAA0371 ZFYVE10	Homo sapiens (Human)	1198	FUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:11676921). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11676921). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11676921}.		cellular response to glucose starvation [GO:0042149]; macroautophagy [GO:0016236]; phosphatidylinositol 5-phosphate metabolic process [GO:1904562]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; protein dephosphorylation [GO:0006470]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	metal ion binding [GO:0046872]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; metal ion binding [GO:0046872]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cellular response to glucose starvation [GO:0042149]; macroautophagy [GO:0016236]; phosphatidylinositol 5-phosphate metabolic process [GO:1904562]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; protein dephosphorylation [GO:0006470]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11676921}. Membrane {ECO:0000269|PubMed:11676921}; Peripheral membrane protein {ECO:0000269|PubMed:11676921}.
Q13616	reviewed	CUL1_HUMAN	Cullin-1 (CUL-1)	CUL1	Homo sapiens (Human)	776	FUNCTION: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346, PubMed:22017875, PubMed:22017877). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25704143, PubMed:25503564). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of CCNE1, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. {ECO:0000269|PubMed:15531760, ECO:0000269|PubMed:15640526, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:19679664, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:22405651, ECO:0000269|PubMed:23263282, ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:9663463}.		animal organ morphogenesis [GO:0009887]; cell population proliferation [GO:0008283]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; plasma membrane [GO:0005886]; SCF ubiquitin ligase complex [GO:0019005]	protein-macromolecule adaptor activity [GO:0030674]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625]	cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; plasma membrane [GO:0005886]; SCF ubiquitin ligase complex [GO:0019005]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625]; animal organ morphogenesis [GO:0009887]; cell population proliferation [GO:0008283]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	
Q13617	reviewed	CUL2_HUMAN	Cullin-2 (CUL-2)	CUL2	Homo sapiens (Human)	745	FUNCTION: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:11384984, PubMed:26138980, PubMed:29779948, PubMed:29775578). CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:9122164, PubMed:10973499, PubMed:11384984, PubMed:12609982, PubMed:24076655). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (PubMed:12609982, PubMed:24076655, PubMed:27565346). The functional specificity of the ECS complex depends on the substrate recognition component (PubMed:9122164, PubMed:10973499, PubMed:26138980, PubMed:29779948, PubMed:29775578). ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (PubMed:9122164, PubMed:10973499). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:26138980, PubMed:29779948, PubMed:29775578). ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). {ECO:0000250|UniProtKB:Q9D4H8, ECO:0000269|PubMed:10973499, ECO:0000269|PubMed:11384984, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:9122164}.		G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]; VCB complex [GO:0030891]	protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]; VCB complex [GO:0030891]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D4H8}.
Q13618	reviewed	CUL3_HUMAN	Cullin-3 (CUL-3)	CUL3 KIAA0617	Homo sapiens (Human)	768	FUNCTION: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 (PubMed:23387299, PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation (PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway (PubMed:29769719). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). The BCR(KLHL25) ubiquitin ligase complex is also involved in lipid synthesis by mediating ubiquitination and degradation of ACLY (PubMed:27664236). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (PubMed:15983046). In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (PubMed:25270598). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (PubMed:27798626). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400). The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions mediates 'Lys-48' ubiquitination and proteasomal degradation of TIAM1 (PubMed:25684205). By controlling the ubiquitination of that RAC1 guanine exchange factors (GEF), regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). {ECO:0000269|PubMed:10500095, ECO:0000269|PubMed:11311237, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16006525, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:17543862, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:19261606, ECO:0000269|PubMed:19995937, ECO:0000269|PubMed:20389280, ECO:0000269|PubMed:21670212, ECO:0000269|PubMed:21840486, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22358839, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22632832, ECO:0000269|PubMed:23213400, ECO:0000269|PubMed:23387299, ECO:0000269|PubMed:23453970, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23576762, ECO:0000269|PubMed:24768539, ECO:0000269|PubMed:25270598, ECO:0000269|PubMed:25684205, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:27664236, ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27798626, ECO:0000269|PubMed:29769719}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell migration [GO:0016477]; cell projection organization [GO:0030030]; cellular response to amino acid stimulus [GO:0071230]; COPII vesicle coating [GO:0048208]; embryonic cleavage [GO:0040016]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; fibroblast apoptotic process [GO:0044346]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; intrinsic apoptotic signaling pathway [GO:0097193]; liver morphogenesis [GO:0072576]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type I interferon production [GO:0032480]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle phase transition [GO:1901992]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of TORC1 signaling [GO:1904263]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]; stem cell division [GO:0017145]; stress fiber assembly [GO:0043149]; trophectodermal cellular morphogenesis [GO:0001831]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]	centrosome [GO:0005813]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polar microtubule [GO:0005827]; postsynapse [GO:0098794]; sperm flagellum [GO:0036126]; spindle pole [GO:0000922]	cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; Notch binding [GO:0005112]; POZ domain binding [GO:0031208]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]	centrosome [GO:0005813]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polar microtubule [GO:0005827]; postsynapse [GO:0098794]; sperm flagellum [GO:0036126]; spindle pole [GO:0000922]; cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; Notch binding [GO:0005112]; POZ domain binding [GO:0031208]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell migration [GO:0016477]; cell projection organization [GO:0030030]; cellular response to amino acid stimulus [GO:0071230]; COPII vesicle coating [GO:0048208]; embryonic cleavage [GO:0040016]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; fibroblast apoptotic process [GO:0044346]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; intrinsic apoptotic signaling pathway [GO:0097193]; liver morphogenesis [GO:0072576]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type I interferon production [GO:0032480]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle phase transition [GO:1901992]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of TORC1 signaling [GO:1904263]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]; stem cell division [GO:0017145]; stress fiber assembly [GO:0043149]; trophectodermal cellular morphogenesis [GO:0001831]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10500095, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:23213400}. Golgi apparatus {ECO:0000269|PubMed:10500095}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:28395323}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23213400}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23213400}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23213400}. Note=Detected along the length of the sperm flagellum and in the cytoplasm of the germ cells (PubMed:28395323). Predominantly found in the nucleus in interphase cells, found at the centrosome at late G2 or prophase, starts accumulating at the spindle poles in prometaphase and stays on the spindle poles and the mitotic spindle at metaphase (PubMed:23213400). {ECO:0000269|PubMed:23213400, ECO:0000269|PubMed:28395323}.
Q13619	reviewed	CUL4A_HUMAN	Cullin-4A (CUL-4A)	CUL4A	Homo sapiens (Human)	759	FUNCTION: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins (PubMed:14578910, PubMed:15811626, PubMed:15548678, PubMed:15448697, PubMed:14739464, PubMed:16678110, PubMed:17041588, PubMed:24209620, PubMed:30166453, PubMed:33854232, PubMed:33854239). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:15811626, PubMed:15548678, PubMed:15448697, PubMed:14739464, PubMed:16678110, PubMed:17041588, PubMed:24209620). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (PubMed:14578910, PubMed:15811626, PubMed:15548678, PubMed:15448697, PubMed:14739464, PubMed:16678110, PubMed:17041588, PubMed:24209620). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component (PubMed:14578910, PubMed:15811626, PubMed:15548678, PubMed:15448697, PubMed:14739464, PubMed:16678110, PubMed:17041588, PubMed:24209620). DCX(DET1-COP1) directs ubiquitination of JUN (PubMed:14739464). DCX(DDB2) directs ubiquitination of XPC (PubMed:15811626). DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition (PubMed:16678110, PubMed:17041588, PubMed:24209620). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of p53/TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:14578910, PubMed:15548678, PubMed:15448697). DCX(DTL) directs autoubiquitination of DTL (PubMed:23478445). In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip (PubMed:16537899). Is involved in ubiquitination of HOXA9 (PubMed:14609952). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). With CUL4B, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:15811626, ECO:0000269|PubMed:16537899, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:17041588, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:24209620, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854239}.		cell population proliferation [GO:0008283]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; G1/S transition of mitotic cell cycle [GO:0000082]; hemopoiesis [GO:0030097]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of granulocyte differentiation [GO:0030853]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; regulation of nucleotide-excision repair [GO:2000819]; rhythmic process [GO:0048511]; ribosome biogenesis [GO:0042254]; somatic stem cell population maintenance [GO:0035019]; spermatogenesis [GO:0007283]; T cell activation [GO:0042110]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; cell population proliferation [GO:0008283]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; G1/S transition of mitotic cell cycle [GO:0000082]; hemopoiesis [GO:0030097]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of granulocyte differentiation [GO:0030853]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; regulation of nucleotide-excision repair [GO:2000819]; rhythmic process [GO:0048511]; ribosome biogenesis [GO:0042254]; somatic stem cell population maintenance [GO:0035019]; spermatogenesis [GO:0007283]; T cell activation [GO:0042110]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	
Q13620	reviewed	CUL4B_HUMAN	Cullin-4B (CUL-4B)	CUL4B KIAA0695	Homo sapiens (Human)	913	FUNCTION: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239, PubMed:22118460). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:29779948, PubMed:22118460). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:16322693, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18235224, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19801544, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854239}.		astrocyte differentiation [GO:0048708]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; neuron projection development [GO:0031175]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein catabolic process [GO:0045732]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; ribosome biogenesis [GO:0042254]; ubiquitin-dependent protein catabolic process [GO:0006511]; UV-damage excision repair [GO:0070914]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ubiquitin protein ligase binding [GO:0031625]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin protein ligase binding [GO:0031625]; astrocyte differentiation [GO:0048708]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; neuron projection development [GO:0031175]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein catabolic process [GO:0045732]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; ribosome biogenesis [GO:0042254]; ubiquitin-dependent protein catabolic process [GO:0006511]; UV-damage excision repair [GO:0070914]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2A432}. Nucleus {ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19801544}. Note=More concentrated in nuclei than in cytoplasm in germinal vesicle (GV) stage oocytes, zygotes and the 2-cell stage, but distributed in the cytoplasm at the MII-stage oocytes. {ECO:0000250|UniProtKB:A2A432}.
Q13621	reviewed	S12A1_HUMAN	Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter)	SLC12A1 NKCC2	Homo sapiens (Human)	1099	FUNCTION: Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation (PubMed:21321328). Electrically silent transporter system (By similarity). {ECO:0000250|UniProtKB:P55014, ECO:0000250|UniProtKB:P55016, ECO:0000269|PubMed:21321328}.		cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; sodium ion homeostasis [GO:0055078]; sodium ion transmembrane transport [GO:0035725]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	sodium:potassium:chloride symporter activity [GO:0008511]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sodium:potassium:chloride symporter activity [GO:0008511]; cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; sodium ion homeostasis [GO:0055078]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:21321328}; Multi-pass membrane protein {ECO:0000255}.
Q13625	reviewed	ASPP2_HUMAN	Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)	TP53BP2 ASPP2 BBP	Homo sapiens (Human)	1128	FUNCTION: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.	MISCELLANEOUS: [Isoform 2]: Due to Alu sequence insertion that creates a shorter but existing form that may have an alternative function. {ECO:0000305}.	cell cycle [GO:0007049]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of cell cycle [GO:0045786]; positive regulation of execution phase of apoptosis [GO:1900119]; signal transduction [GO:0007165]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; SH3 domain binding [GO:0017124]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; SH3 domain binding [GO:0017124]; cell cycle [GO:0007049]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of cell cycle [GO:0045786]; positive regulation of execution phase of apoptosis [GO:1900119]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.
Q13627	reviewed	DYR1A_HUMAN	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)	DYRK1A DYRK MNB MNBH	Homo sapiens (Human)	763	FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:21127067, PubMed:8769099, PubMed:30773093, PubMed:20981014, PubMed:23665168). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}.		amyloid-beta formation [GO:0034205]; circadian rhythm [GO:0007623]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA methylation-dependent heterochromatin formation [GO:0090310]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; nervous system development [GO:0007399]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of RNA splicing [GO:0033120]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal protein binding [GO:0008092]; histone H3T45 kinase activity [GO:0140857]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein self-association [GO:0043621]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; transcription coactivator activity [GO:0003713]; tubulin binding [GO:0015631]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal protein binding [GO:0008092]; histone H3T45 kinase activity [GO:0140857]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein self-association [GO:0043621]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; transcription coactivator activity [GO:0003713]; tubulin binding [GO:0015631]; amyloid-beta formation [GO:0034205]; circadian rhythm [GO:0007623]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA methylation-dependent heterochromatin formation [GO:0090310]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; nervous system development [GO:0007399]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of RNA splicing [GO:0033120]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:25620562}. Nucleus speckle {ECO:0000250|UniProtKB:Q61214}.
Q13630	reviewed	FCL_HUMAN	GDP-L-fucose synthase (EC 1.1.1.271) (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase) (Protein FX) (Red cell NADP(H)-binding protein) (Short-chain dehydrogenase/reductase family 4E member 1)	GFUS SDR4E1 TSTA3	Homo sapiens (Human)	321	FUNCTION: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. {ECO:0000269|PubMed:8910301}.		'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; GDP-mannose metabolic process [GO:0019673]; leukocyte cell-cell adhesion [GO:0007159]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	electron transfer activity [GO:0009055]; GDP-4-dehydro-D-rhamnose reductase activity [GO:0042356]; GDP-L-fucose synthase activity [GO:0050577]; GDP-mannose 3,5-epimerase activity [GO:0047918]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; electron transfer activity [GO:0009055]; GDP-4-dehydro-D-rhamnose reductase activity [GO:0042356]; GDP-L-fucose synthase activity [GO:0050577]; GDP-mannose 3,5-epimerase activity [GO:0047918]; identical protein binding [GO:0042802]; 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; GDP-mannose metabolic process [GO:0019673]; leukocyte cell-cell adhesion [GO:0007159]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]	
Q13634	reviewed	CAD18_HUMAN	Cadherin-18 (Cadherin-14)	CDH18 CDH14	Homo sapiens (Human)	790	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q13635	reviewed	PTC1_HUMAN	Protein patched homolog 1 (PTC) (PTC1)	PTCH1 PTCH	Homo sapiens (Human)	1447	FUNCTION: Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. {ECO:0000269|PubMed:21537345}.		animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell differentiation involved in kidney development [GO:0061005]; cell fate determination [GO:0001709]; cell proliferation involved in metanephros development [GO:0072203]; cellular response to cholesterol [GO:0071397]; commissural neuron axon guidance [GO:0071679]; dorsal/ventral neural tube patterning [GO:0021904]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; epidermal cell fate specification [GO:0009957]; glucose homeostasis [GO:0042593]; heart morphogenesis [GO:0003007]; hindlimb morphogenesis [GO:0035137]; in utero embryonic development [GO:0001701]; keratinocyte proliferation [GO:0043616]; limb morphogenesis [GO:0035108]; liver regeneration [GO:0097421]; mammary gland duct morphogenesis [GO:0060603]; mammary gland epithelial cell differentiation [GO:0060644]; metanephric collecting duct development [GO:0072205]; negative regulation of cell division [GO:0051782]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural plate axis specification [GO:0021997]; neural tube closure [GO:0001843]; neural tube patterning [GO:0021532]; pharyngeal system development [GO:0060037]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal cell differentiation [GO:0045606]; prostate gland development [GO:0030850]; protein localization to plasma membrane [GO:0072659]; protein processing [GO:0016485]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization [GO:0032880]; regulation of smoothened signaling pathway [GO:0008589]; response to chlorate [GO:0010157]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; somite development [GO:0061053]; spermatid development [GO:0007286]; spinal cord motor neuron differentiation [GO:0021522]; stem cell proliferation [GO:0072089]	apical part of cell [GO:0045177]; axonal growth cone [GO:0044295]; caveola [GO:0005901]; ciliary membrane [GO:0060170]; dendritic growth cone [GO:0044294]; endocytic vesicle membrane [GO:0030666]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; cyclin binding [GO:0030332]; hedgehog family protein binding [GO:0097108]; hedgehog receptor activity [GO:0008158]; heparin binding [GO:0008201]; patched binding [GO:0005113]; protein-containing complex binding [GO:0044877]; smoothened binding [GO:0005119]	apical part of cell [GO:0045177]; axonal growth cone [GO:0044295]; caveola [GO:0005901]; ciliary membrane [GO:0060170]; dendritic growth cone [GO:0044294]; endocytic vesicle membrane [GO:0030666]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; cyclin binding [GO:0030332]; hedgehog family protein binding [GO:0097108]; hedgehog receptor activity [GO:0008158]; heparin binding [GO:0008201]; patched binding [GO:0005113]; protein-containing complex binding [GO:0044877]; smoothened binding [GO:0005119]; animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell differentiation involved in kidney development [GO:0061005]; cell fate determination [GO:0001709]; cell proliferation involved in metanephros development [GO:0072203]; cellular response to cholesterol [GO:0071397]; commissural neuron axon guidance [GO:0071679]; dorsal/ventral neural tube patterning [GO:0021904]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; epidermal cell fate specification [GO:0009957]; glucose homeostasis [GO:0042593]; heart morphogenesis [GO:0003007]; hindlimb morphogenesis [GO:0035137]; in utero embryonic development [GO:0001701]; keratinocyte proliferation [GO:0043616]; limb morphogenesis [GO:0035108]; liver regeneration [GO:0097421]; mammary gland duct morphogenesis [GO:0060603]; mammary gland epithelial cell differentiation [GO:0060644]; metanephric collecting duct development [GO:0072205]; negative regulation of cell division [GO:0051782]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural plate axis specification [GO:0021997]; neural tube closure [GO:0001843]; neural tube patterning [GO:0021532]; pharyngeal system development [GO:0060037]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal cell differentiation [GO:0045606]; prostate gland development [GO:0030850]; protein localization to plasma membrane [GO:0072659]; protein processing [GO:0016485]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization [GO:0032880]; regulation of smoothened signaling pathway [GO:0008589]; response to chlorate [GO:0010157]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; somite development [GO:0061053]; spermatid development [GO:0007286]; spinal cord motor neuron differentiation [GO:0021522]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q61115}; Multi-pass membrane protein {ECO:0000255}.
Q13636	reviewed	RAB31_HUMAN	Ras-related protein Rab-31 (Ras-related protein Rab-22B)	RAB31 RAB22B	Homo sapiens (Human)	194	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000269|PubMed:17189207, ECO:0000269|PubMed:17678623, ECO:0000269|PubMed:19725050, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21586568}.		cellular response to insulin stimulus [GO:0032869]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; phagosome maturation [GO:0090382]; positive regulation of phagocytosis, engulfment [GO:0060100]; receptor internalization [GO:0031623]; regulated exocytosis [GO:0045055]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome membrane [GO:0036186]; endomembrane system [GO:0012505]; phagocytic cup [GO:0001891]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network membrane [GO:0032588]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome membrane [GO:0036186]; endomembrane system [GO:0012505]; phagocytic cup [GO:0001891]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network membrane [GO:0032588]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cellular response to insulin stimulus [GO:0032869]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; phagosome maturation [GO:0090382]; positive regulation of phagocytosis, engulfment [GO:0060100]; receptor internalization [GO:0031623]; regulated exocytosis [GO:0045055]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:17189207, ECO:0000269|PubMed:17678623, ECO:0000269|PubMed:19725050, ECO:0000269|PubMed:21586568}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:17189207, ECO:0000269|PubMed:21586568}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:21255211}.
Q13637	reviewed	RAB32_HUMAN	Ras-related protein Rab-32	RAB32	Homo sapiens (Human)	225	FUNCTION: Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:Q9CZE3, ECO:0000269|PubMed:12186851, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:23084991}.		antigen processing and presentation [GO:0019882]; endosome to melanosome transport [GO:0035646]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; mitochondrion organization [GO:0007005]; phagosome maturation [GO:0090382]; protein localization to membrane [GO:0072657]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; trans-Golgi network [GO:0005802]	AP-1 adaptor complex binding [GO:0035650]; AP-3 adaptor complex binding [GO:0035651]; BLOC-2 complex binding [GO:0036461]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; trans-Golgi network [GO:0005802]; AP-1 adaptor complex binding [GO:0035650]; AP-3 adaptor complex binding [GO:0035651]; BLOC-2 complex binding [GO:0036461]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; antigen processing and presentation [GO:0019882]; endosome to melanosome transport [GO:0035646]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; mitochondrion organization [GO:0007005]; phagosome maturation [GO:0090382]; protein localization to membrane [GO:0072657]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12186851}. Mitochondrion outer membrane {ECO:0000269|PubMed:23084991, ECO:0000305|PubMed:12186851}; Lipid-anchor {ECO:0000305|PubMed:12186851}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome {ECO:0000250|UniProtKB:Q9CZE3}. Melanosome membrane {ECO:0000269|PubMed:23084991}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991). {ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:23084991}.
Q13639	reviewed	5HT4R_HUMAN	5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4)	HTR4	Homo sapiens (Human)	388	FUNCTION: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.	MISCELLANEOUS: [Isoform 5-HT4(E)]: Mainly expressed in atria and cardiac ventricle. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5-HT4(I)]: Expressed in all cardiovascular tissues analyzed. {ECO:0000305}.	chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; large intestinal transit [GO:0120056]; maintenance of gastrointestinal epithelium [GO:0030277]; mucus secretion [GO:0070254]; regulation of appetite [GO:0032098]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; endosome [GO:0005768]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin receptor activity [GO:0099589]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; endosome [GO:0005768]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin receptor activity [GO:0099589]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; large intestinal transit [GO:0120056]; maintenance of gastrointestinal epithelium [GO:0030277]; mucus secretion [GO:0070254]; regulation of appetite [GO:0032098]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with NHERF1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000250}.
Q13641	reviewed	TPBG_HUMAN	Trophoblast glycoprotein (5T4 oncofetal antigen) (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (M6P1) (Wnt-activated inhibitory factor 1) (WAIF1)	TPBG 5T4	Homo sapiens (Human)	420	FUNCTION: May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. {ECO:0000269|PubMed:22100263}.	MISCELLANEOUS: Antigen 5T4 is overexpressed by a wide spectrum of cancers, including colorectal, ovarian and gastric, but with a limited normal tissue expression. Could be used for tumor immunotherapy.; MISCELLANEOUS: Reduction of TPBG levels by siRNA significantly enhanced the beta-catenin/TCF transcription-based reporter pBAR activation in response to Wnt stimulation.	cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; dendrite arborization [GO:0140059]; mesenchymal cell migration [GO:0090497]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; olfactory learning [GO:0008355]; positive regulation of chemotaxis [GO:0050921]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of synapse assembly [GO:0051965]; protein localization to plasma membrane [GO:0072659]; synaptic transmission, GABAergic [GO:0051932]	axon terminus [GO:0043679]; cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]		axon terminus [GO:0043679]; cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; dendrite arborization [GO:0140059]; mesenchymal cell migration [GO:0090497]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; olfactory learning [GO:0008355]; positive regulation of chemotaxis [GO:0050921]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of synapse assembly [GO:0051965]; protein localization to plasma membrane [GO:0072659]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24582434}; Single-pass type I membrane protein {ECO:0000269|PubMed:24582434}.
Q13642	reviewed	FHL1_HUMAN	Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1)	FHL1 SLIM1	Homo sapiens (Human)	323	FUNCTION: May have an involvement in muscle development or hypertrophy.		animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; positive regulation of potassium ion transport [GO:0043268]; regulation of membrane depolarization [GO:0003254]; regulation of potassium ion transmembrane transporter activity [GO:1901016]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; positive regulation of potassium ion transport [GO:0043268]; regulation of membrane depolarization [GO:0003254]; regulation of potassium ion transmembrane transporter activity [GO:1901016]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm, cytosol. Note=Predominantly nuclear in myoblasts but is cytosolic in differentiated myotubes.
Q13643	reviewed	FHL3_HUMAN	Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM-protein 2) (SLIM-2)	FHL3 SLIM2	Homo sapiens (Human)	280	FUNCTION: Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. {ECO:0000250|UniProtKB:Q9R059}.		actin cytoskeleton organization [GO:0030036]; muscle organ development [GO:0007517]	focal adhesion [GO:0005925]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]	focal adhesion [GO:0005925]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; actin cytoskeleton organization [GO:0030036]; muscle organ development [GO:0007517]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9R059}. Cytoplasm {ECO:0000250|UniProtKB:Q9R059}.
Q13651	reviewed	I10R1_HUMAN	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)	IL10RA IL10R	Homo sapiens (Human)	578	FUNCTION: Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683). {ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16982608, ECO:0000269|PubMed:26962683}.		cytokine-mediated signaling pathway [GO:0019221]; intestinal epithelial structure maintenance [GO:0060729]; negative regulation of autophagy [GO:0010507]; negative regulation of inflammatory response [GO:0050728]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of synapse organization [GO:0050807]; response to lipopolysaccharide [GO:0032496]; ubiquitin-dependent endocytosis [GO:0070086]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	interleukin-10 binding [GO:0019969]; interleukin-10 receptor activity [GO:0004920]; signaling receptor activity [GO:0038023]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; interleukin-10 binding [GO:0019969]; interleukin-10 receptor activity [GO:0004920]; signaling receptor activity [GO:0038023]; cytokine-mediated signaling pathway [GO:0019221]; intestinal epithelial structure maintenance [GO:0060729]; negative regulation of autophagy [GO:0010507]; negative regulation of inflammatory response [GO:0050728]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of synapse organization [GO:0050807]; response to lipopolysaccharide [GO:0032496]; ubiquitin-dependent endocytosis [GO:0070086]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22087322, ECO:0000269|PubMed:26962683}; Single-pass type I membrane protein. Cytoplasm {ECO:0000269|PubMed:26962683}.
Q13671	reviewed	RIN1_HUMAN	Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)	RIN1	Homo sapiens (Human)	783	FUNCTION: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}.	MISCELLANEOUS: [Isoform RIN1-delta]: Shows reduced ability to bind to Ras and 14-3-3 proteins. {ECO:0000305}.	endocytosis [GO:0006897]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; endocytosis [GO:0006897]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11784866}. Membrane {ECO:0000269|PubMed:11784866}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11784866}. Note=Some amount is membrane-associated.
Q13683	reviewed	ITA7_HUMAN	Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]	ITGA7 UNQ406/PRO768	Homo sapiens (Human)	1181	FUNCTION: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. {ECO:0000250, ECO:0000269|PubMed:10694445, ECO:0000269|PubMed:17641293, ECO:0000269|PubMed:9307969}.		cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; muscle organ development [GO:0007517]; regulation of cell shape [GO:0008360]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]; metal ion binding [GO:0046872]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; muscle organ development [GO:0007517]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q13685	reviewed	AAMP_HUMAN	Angio-associated migratory cell protein	AAMP	Homo sapiens (Human)	434	FUNCTION: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. {ECO:0000269|PubMed:10329261, ECO:0000269|PubMed:18634987}.		angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; positive regulation of endothelial cell migration [GO:0010595]; smooth muscle cell migration [GO:0014909]	cell surface [GO:0009986]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]	heparin binding [GO:0008201]	cell surface [GO:0009986]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; heparin binding [GO:0008201]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; positive regulation of endothelial cell migration [GO:0010595]; smooth muscle cell migration [GO:0014909]	SUBCELLULAR LOCATION: Cell membrane. Cytoplasm.
Q13686	reviewed	ALKB1_HUMAN	Nucleic acid dioxygenase ALKBH1 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 1) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase ALKBH1) (EC 1.14.11.51) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) (EC 1.14.11.33) (mRNA N(3)-methylcytidine demethylase) (EC 1.14.11.-)	ALKBH1 ABH ABH1 ALKBH	Homo sapiens (Human)	389	FUNCTION: Dioxygenase that acts as on nucleic acids, such as DNA and tRNA (PubMed:18603530, PubMed:27745969, PubMed:27497299). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:18603530, PubMed:27497299). A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment (PubMed:27745969, PubMed:27497299). Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs (PubMed:27745969). Acts as a regulator of translation initiation and elongation in response to glucose deprivation: regulates both translation initiation, by mediating demethylation of tRNA(Met), and translation elongation, N(1)-methyladenine-containing tRNAs being preferentially recruited to polysomes to promote translation elongation (PubMed:27745969). In mitochondrion, specifically interacts with mt-tRNA(Met) and mediates oxidation of mt-tRNA(Met) methylated at cytosine(34) to form 5-formylcytosine (f(5)c) at this position (PubMed:27497299). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299). Specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:30392959, PubMed:30017583). N(6)-methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing (By similarity). Demethylates mRNAs containing N(3)-methylcytidine modification (PubMed:31188562). Also able to repair alkylated single-stranded DNA by oxidative demethylation, but with low activity (PubMed:18603530). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites (PubMed:19959401). DNA lyase activity does not require alpha-ketboglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product (PubMed:19959401, PubMed:23577621). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB42, ECO:0000269|PubMed:18603530, ECO:0000269|PubMed:19959401, ECO:0000269|PubMed:23577621, ECO:0000269|PubMed:27497299, ECO:0000269|PubMed:27745969, ECO:0000269|PubMed:30017583, ECO:0000269|PubMed:30392959, ECO:0000269|PubMed:31188562}.		developmental growth [GO:0048589]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; DNA repair [GO:0006281]; in utero embryonic development [GO:0001701]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; oxidative demethylation [GO:0070989]; oxidative RNA demethylation [GO:0035513]; oxidative single-stranded DNA demethylation [GO:0035552]; placenta development [GO:0001890]; regulation of mitochondrial translation [GO:0070129]; regulation of translational elongation [GO:0006448]; regulation of translational initiation [GO:0006446]; RNA repair [GO:0042245]; tRNA demethylation [GO:1990983]; tRNA wobble cytosine modification [GO:0002101]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; euchromatin [GO:0000791]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; chemoattractant activity [GO:0042056]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; ferrous iron binding [GO:0008198]; methylcytosine dioxygenase activity [GO:0070579]; oxidative DNA demethylase activity [GO:0035516]; oxidative RNA demethylase activity [GO:0035515]; tRNA binding [GO:0000049]; tRNA demethylase activity [GO:1990984]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; euchromatin [GO:0000791]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; chemoattractant activity [GO:0042056]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; ferrous iron binding [GO:0008198]; methylcytosine dioxygenase activity [GO:0070579]; oxidative DNA demethylase activity [GO:0035516]; oxidative RNA demethylase activity [GO:0035515]; tRNA binding [GO:0000049]; tRNA demethylase activity [GO:1990984]; developmental growth [GO:0048589]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; DNA repair [GO:0006281]; in utero embryonic development [GO:0001701]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; oxidative demethylation [GO:0070989]; oxidative RNA demethylation [GO:0035513]; oxidative single-stranded DNA demethylation [GO:0035552]; placenta development [GO:0001890]; regulation of mitochondrial translation [GO:0070129]; regulation of translational elongation [GO:0006448]; regulation of translational initiation [GO:0006446]; RNA repair [GO:0042245]; tRNA demethylation [GO:1990983]; tRNA wobble cytosine modification [GO:0002101]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22961808}. Mitochondrion {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530, ECO:0000269|PubMed:27497299}. Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli (By similarity). {ECO:0000250|UniProtKB:P0CB42}.
Q13698	reviewed	CAC1S_HUMAN	Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Voltage-gated calcium channel subunit alpha Cav1.1)	CACNA1S CACH1 CACN1 CACNL1A3	Homo sapiens (Human)	1873	FUNCTION: Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcoplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. {ECO:0000269|PubMed:28012042}.		calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to caffeine [GO:0071313]; endoplasmic reticulum organization [GO:0007029]; extraocular skeletal muscle development [GO:0002074]; muscle contraction [GO:0006936]; myoblast fusion [GO:0007520]; neuromuscular junction development [GO:0007528]; positive regulation of muscle contraction [GO:0045933]; regulation of monoatomic ion transmembrane transport [GO:0034765]; release of sequestered calcium ion into cytosol [GO:0051209]; skeletal muscle adaptation [GO:0043501]; skeletal muscle fiber development [GO:0048741]; skeletal system development [GO:0001501]; striated muscle contraction [GO:0006941]	cytoplasm [GO:0005737]; I band [GO:0031674]; L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891]	calmodulin binding [GO:0005516]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; small molecule binding [GO:0036094]; voltage-gated calcium channel activity [GO:0005245]	cytoplasm [GO:0005737]; I band [GO:0031674]; L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891]; calmodulin binding [GO:0005516]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; small molecule binding [GO:0036094]; voltage-gated calcium channel activity [GO:0005245]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to caffeine [GO:0071313]; endoplasmic reticulum organization [GO:0007029]; extraocular skeletal muscle development [GO:0002074]; muscle contraction [GO:0006936]; myoblast fusion [GO:0007520]; neuromuscular junction development [GO:0007528]; positive regulation of muscle contraction [GO:0045933]; regulation of monoatomic ion transmembrane transport [GO:0034765]; release of sequestered calcium ion into cytosol [GO:0051209]; skeletal muscle adaptation [GO:0043501]; skeletal muscle fiber development [GO:0048741]; skeletal system development [GO:0001501]; striated muscle contraction [GO:0006941]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:28012042}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P07293}.
Q13702	reviewed	RAPSN_HUMAN	43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein) (RING finger protein 205)	RAPSN RNF205	Homo sapiens (Human)	412	FUNCTION: Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.		chemical synaptic transmission [GO:0007268]; establishment of protein localization to postsynaptic membrane [GO:1903540]; motor neuron apoptotic process [GO:0097049]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of motor neuron apoptotic process [GO:2000673]; positive regulation of neuromuscular synaptic transmission [GO:1900075]; regulation of postsynaptic membrane organization [GO:1901626]; synaptic transmission, cholinergic [GO:0007271]	centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]	acetylcholine receptor binding [GO:0033130]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; protein-membrane adaptor activity [GO:0043495]; structural constituent of postsynaptic specialization [GO:0098879]	centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; acetylcholine receptor binding [GO:0033130]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; protein-membrane adaptor activity [GO:0043495]; structural constituent of postsynaptic specialization [GO:0098879]; chemical synaptic transmission [GO:0007268]; establishment of protein localization to postsynaptic membrane [GO:1903540]; motor neuron apoptotic process [GO:0097049]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of motor neuron apoptotic process [GO:2000673]; positive regulation of neuromuscular synaptic transmission [GO:1900075]; regulation of postsynaptic membrane organization [GO:1901626]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic surface of postsynaptic membranes.
Q13705	reviewed	AVR2B_HUMAN	Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)	ACVR2B	Homo sapiens (Human)	512	FUNCTION: Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. {ECO:0000269|PubMed:8622651}.	MISCELLANEOUS: [Isoform ActR-IIB1]: Produced from the insertion in the transcript of 82 base pairs, leading to frameshift and protein truncation. May be not functional. {ECO:0000305}.	activin receptor signaling pathway [GO:0032924]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; embryonic foregut morphogenesis [GO:0048617]; gastrulation with mouth forming second [GO:0001702]; heart development [GO:0007507]; insulin secretion [GO:0030073]; kidney development [GO:0001822]; lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; mesoderm development [GO:0007498]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis of dentin-containing tooth [GO:0042475]; organ growth [GO:0035265]; pancreas development [GO:0031016]; phosphorylation [GO:0016310]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; post-embryonic development [GO:0009791]; regulation of DNA-templated transcription [GO:0006355]; response to glucose [GO:0009749]; retina vasculature development in camera-type eye [GO:0061298]; roof of mouth development [GO:0060021]; signal transduction [GO:0007165]; skeletal system morphogenesis [GO:0048705]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; venous blood vessel development [GO:0060841]	activin receptor complex [GO:0048179]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]	activin binding [GO:0048185]; activin receptor activity [GO:0017002]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; kinase activator activity [GO:0019209]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]	activin receptor complex [GO:0048179]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; activin binding [GO:0048185]; activin receptor activity [GO:0017002]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; kinase activator activity [GO:0019209]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; activin receptor signaling pathway [GO:0032924]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; embryonic foregut morphogenesis [GO:0048617]; gastrulation with mouth forming second [GO:0001702]; heart development [GO:0007507]; insulin secretion [GO:0030073]; kidney development [GO:0001822]; lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; mesoderm development [GO:0007498]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis of dentin-containing tooth [GO:0042475]; organ growth [GO:0035265]; pancreas development [GO:0031016]; phosphorylation [GO:0016310]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; post-embryonic development [GO:0009791]; regulation of DNA-templated transcription [GO:0006355]; response to glucose [GO:0009749]; retina vasculature development in camera-type eye [GO:0061298]; roof of mouth development [GO:0060021]; signal transduction [GO:0007165]; skeletal system morphogenesis [GO:0048705]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; venous blood vessel development [GO:0060841]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31665064}; Single-pass type I membrane protein {ECO:0000250}.
Q13724	reviewed	MOGS_HUMAN	Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I)	MOGS GCS1	Homo sapiens (Human)	837	FUNCTION: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.		oligosaccharide metabolic process [GO:0009311]; protein folding [GO:0006457]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [GO:0004573]; glucosidase activity [GO:0015926]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [GO:0004573]; glucosidase activity [GO:0015926]; oligosaccharide metabolic process [GO:0009311]; protein folding [GO:0006457]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Q13733	reviewed	AT1A4_HUMAN	Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-4)	ATP1A4 ATP1AL2	Homo sapiens (Human)	1029	FUNCTION: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.		cell surface receptor signaling pathway [GO:0007166]; establishment of localization in cell [GO:0051649]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; monoatomic ion transport [GO:0006811]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; proton transmembrane transport [GO:1902600]; regulation of cellular pH [GO:0030641]; regulation of membrane potential [GO:0042391]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; spermatogenesis [GO:0007283]; transport across blood-brain barrier [GO:0150104]	cell projection [GO:0042995]; membrane raft [GO:0045121]; photoreceptor cell cilium [GO:0097733]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm midpiece [GO:0097225]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]	cell projection [GO:0042995]; membrane raft [GO:0045121]; photoreceptor cell cilium [GO:0097733]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm midpiece [GO:0097225]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; cell surface receptor signaling pathway [GO:0007166]; establishment of localization in cell [GO:0051649]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; monoatomic ion transport [GO:0006811]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; proton transmembrane transport [GO:1902600]; regulation of cellular pH [GO:0030641]; regulation of membrane potential [GO:0042391]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; spermatogenesis [GO:0007283]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16175638}; Multi-pass membrane protein {ECO:0000269|PubMed:16175638}. Note=In mature sperm, located in the principle piece of the sperm flagellum.
Q13740	reviewed	CD166_HUMAN	CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)	ALCAM MEMD	Homo sapiens (Human)	583	FUNCTION: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation (PubMed:29263213). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). {ECO:0000250|UniProtKB:P42292, ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:15496415, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:29263213, ECO:0000269|PubMed:7760007}.; FUNCTION: [Isoform 3]: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. {ECO:0000269|PubMed:15496415}.	MISCELLANEOUS: [Isoform 3]: Secreted form, inhibits isoform 1 homophilic interaction. {ECO:0000305}.	adaptive immune response [GO:0002250]; axon extension involved in axon guidance [GO:0048846]; cell adhesion [GO:0007155]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; motor neuron axon guidance [GO:0008045]; neuron projection extension [GO:1990138]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165]	axon [GO:0030424]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]	axon [GO:0030424]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; adaptive immune response [GO:0002250]; axon extension involved in axon guidance [GO:0048846]; cell adhesion [GO:0007155]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; motor neuron axon guidance [GO:0008045]; neuron projection extension [GO:1990138]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:23169771, ECO:0000269|PubMed:24740813, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:7760007}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q61490}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q61490}. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse (PubMed:15294938). {ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:15496415}.
Q13751	reviewed	LAMB3_HUMAN	Laminin subunit beta-3 (Epiligrin subunit bata) (Kalinin B1 chain) (Kalinin subunit beta) (Laminin B1k chain) (Laminin-5 subunit beta) (Nicein subunit beta)	LAMB3 LAMNB1	Homo sapiens (Human)	1172	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.		brown fat cell differentiation [GO:0050873]; cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; epidermis development [GO:0008544]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; laminin-5 complex [GO:0005610]	protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; laminin-5 complex [GO:0005610]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]; brown fat cell differentiation [GO:0050873]; cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; epidermis development [GO:0008544]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
Q13753	reviewed	LAMC2_HUMAN	Laminin subunit gamma-2 (Cell-scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Epiligrin subunit gamma) (Kalinin subunit gamma) (Kalinin/nicein/epiligrin 100 kDa subunit) (Ladsin 140 kDa subunit) (Laminin B2t chain) (Laminin-5 subunit gamma) (Large adhesive scatter factor 140 kDa subunit) (Nicein subunit gamma)	LAMC2 LAMB2T LAMNB2	Homo sapiens (Human)	1193	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. {ECO:0000269|PubMed:8265624}.	MISCELLANEOUS: Binds heparin. {ECO:0000250}.	cell adhesion [GO:0007155]; epidermis development [GO:0008544]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]	cell cortex [GO:0005938]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-2 complex [GO:0005607]; perinuclear region of cytoplasm [GO:0048471]	heparin binding [GO:0008201]	cell cortex [GO:0005938]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-2 complex [GO:0005607]; perinuclear region of cytoplasm [GO:0048471]; heparin binding [GO:0008201]; cell adhesion [GO:0007155]; epidermis development [GO:0008544]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
Q13761	reviewed	RUNX3_HUMAN	Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit)	RUNX3 AML2 CBFA3 PEBP2A3	Homo sapiens (Human)	415	FUNCTION: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}.		chondrocyte differentiation [GO:0002062]; hemopoiesis [GO:0030097]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of cell cycle [GO:0045786]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; ossification [GO:0001503]; peripheral nervous system neuron development [GO:0048935]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cell differentiation [GO:0045595]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to transforming growth factor beta [GO:0071559]	chromatin [GO:0000785]; core-binding factor complex [GO:0016513]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]	chromatin [GO:0000785]; core-binding factor complex [GO:0016513]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]; chondrocyte differentiation [GO:0002062]; hemopoiesis [GO:0030097]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of cell cycle [GO:0045786]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; ossification [GO:0001503]; peripheral nervous system neuron development [GO:0048935]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cell differentiation [GO:0045595]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to transforming growth factor beta [GO:0071559]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00399, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20599712}. Cytoplasm {ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20599712}. Note=The tyrosine phosphorylated form localizes to the cytoplasm. Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. {ECO:0000269|PubMed:20599712}.
Q13765	reviewed	NACA_HUMAN	Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2)	NACA HSD48	Homo sapiens (Human)	215	FUNCTION: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678, ECO:0000269|PubMed:9877153}.		cardiac ventricle development [GO:0003231]; heart trabecula morphogenesis [GO:0061384]; negative regulation of protein localization to endoplasmic reticulum [GO:1905551]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; regulation of skeletal muscle fiber development [GO:0048742]; skeletal muscle tissue regeneration [GO:0043403]; translation [GO:0006412]; wound healing [GO:0042060]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]	DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]; DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]; cardiac ventricle development [GO:0003231]; heart trabecula morphogenesis [GO:0061384]; negative regulation of protein localization to endoplasmic reticulum [GO:1905551]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; regulation of skeletal muscle fiber development [GO:0048742]; skeletal muscle tissue regeneration [GO:0043403]; translation [GO:0006412]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:12689679, ECO:0000269|PubMed:15299025, ECO:0000269|PubMed:20214399}. Nucleus {ECO:0000269|PubMed:12689679, ECO:0000269|PubMed:15299025, ECO:0000269|PubMed:20214399}. Note=The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus. {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:20214399}.
Q13769	reviewed	THOC5_HUMAN	THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90)	THOC5 C22orf19 KIAA0983	Homo sapiens (Human)	683	FUNCTION: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.; FUNCTION: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.		monocyte differentiation [GO:0030224]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; primitive hemopoiesis [GO:0060215]; RNA splicing [GO:0008380]; viral mRNA export from host cell nucleus [GO:0046784]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]; mRNA binding [GO:0003729]; monocyte differentiation [GO:0030224]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; primitive hemopoiesis [GO:0060215]; RNA splicing [GO:0008380]; viral mRNA export from host cell nucleus [GO:0046784]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19059247, ECO:0000269|PubMed:19165146}. Cytoplasm {ECO:0000269|PubMed:19059247}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000269|PubMed:19059247}.
Q13772	reviewed	NCOA4_HUMAN	Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ret-activating protein ELE1)	NCOA4 ARA70 ELE1 RFG	Homo sapiens (Human)	614	FUNCTION: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. {ECO:0000269|PubMed:10347167}.		cellular response to estrogen stimulus [GO:0071391]; cellular response to testosterone stimulus [GO:0071394]; intracellular estrogen receptor signaling pathway [GO:0030520]; intracellular iron ion homeostasis [GO:0006879]; male gonad development [GO:0008584]; protein targeting to lysosome [GO:0006622]; response to hormone [GO:0009725]	autolysosome [GO:0044754]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]	autolysosome [GO:0044754]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; cellular response to estrogen stimulus [GO:0071391]; cellular response to testosterone stimulus [GO:0071394]; intracellular estrogen receptor signaling pathway [GO:0030520]; intracellular iron ion homeostasis [GO:0006879]; male gonad development [GO:0008584]; protein targeting to lysosome [GO:0006622]; response to hormone [GO:0009725]	
Q13790	reviewed	APOF_HUMAN	Apolipoprotein F (Apo-F) (Lipid transfer inhibitor protein) (LTIP)	APOF	Homo sapiens (Human)	326	FUNCTION: Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII. {ECO:0000269|PubMed:9880564}.		cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]	extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]	cholesterol binding [GO:0015485]; lipid transporter activity [GO:0005319]; signaling receptor binding [GO:0005102]	extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; cholesterol binding [GO:0015485]; lipid transporter activity [GO:0005319]; signaling receptor binding [GO:0005102]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:204339, ECO:0000269|PubMed:28935895, ECO:0000269|PubMed:8093033}.
Q13794	reviewed	APR_HUMAN	Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)	PMAIP1 NOXA	Homo sapiens (Human)	54	FUNCTION: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615, ECO:0000269|PubMed:17389404}.		apoptotic process [GO:0006915]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of mitochondrial membrane potential [GO:0010917]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; proteasomal protein catabolic process [GO:0010498]; reactive oxygen species metabolic process [GO:0072593]; regulation of mitochondrial membrane permeability [GO:0046902]; release of cytochrome c from mitochondria [GO:0001836]; response to dsRNA [GO:0043331]; T cell homeostasis [GO:0043029]	Bcl-2 family protein complex [GO:0097136]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]		Bcl-2 family protein complex [GO:0097136]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of mitochondrial membrane potential [GO:0010917]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; proteasomal protein catabolic process [GO:0010498]; reactive oxygen species metabolic process [GO:0072593]; regulation of mitochondrial membrane permeability [GO:0046902]; release of cytochrome c from mitochondria [GO:0001836]; response to dsRNA [GO:0043331]; T cell homeostasis [GO:0043029]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615}.
Q13795	reviewed	ARFRP_HUMAN	ADP-ribosylation factor-related protein 1 (ARF-related protein 1) (ARP)	ARFRP1 ARP1	Homo sapiens (Human)	201	FUNCTION: Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. {ECO:0000250|UniProtKB:Q8BXL7}.		gastrulation [GO:0007369]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; protein localization to Golgi apparatus [GO:0034067]; retrograde transport, endosome to Golgi [GO:0042147]; signal transduction [GO:0007165]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; gastrulation [GO:0007369]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; protein localization to Golgi apparatus [GO:0034067]; retrograde transport, endosome to Golgi [GO:0042147]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:15077113}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8BXL7}. Note=Located in the trans-Golgi in the GTP-bound active state. {ECO:0000250|UniProtKB:Q8BXL7}.
Q13796	reviewed	SHRM2_HUMAN	Protein Shroom2 (Apical-like protein) (Protein APXL)	SHROOM2 APXL	Homo sapiens (Human)	1616	FUNCTION: May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; apical protein localization [GO:0045176]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; camera-type eye morphogenesis [GO:0048593]; cell migration [GO:0016477]; cellular pigment accumulation [GO:0043482]; ear development [GO:0043583]; establishment of melanosome localization [GO:0032401]; eye pigment granule organization [GO:0008057]; lens morphogenesis in camera-type eye [GO:0002089]; melanosome organization [GO:0032438]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; ligand-gated sodium channel activity [GO:0015280]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; ligand-gated sodium channel activity [GO:0015280]; actin filament organization [GO:0007015]; apical protein localization [GO:0045176]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; camera-type eye morphogenesis [GO:0048593]; cell migration [GO:0016477]; cellular pigment accumulation [GO:0043482]; ear development [GO:0043583]; establishment of melanosome localization [GO:0032401]; eye pigment granule organization [GO:0008057]; lens morphogenesis in camera-type eye [GO:0002089]; melanosome organization [GO:0032438]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associates with cortical F-actin. {ECO:0000250}.
Q13797	reviewed	ITA9_HUMAN	Integrin alpha-9 (Integrin alpha-RLC)	ITGA9	Homo sapiens (Human)	1035	FUNCTION: Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. {ECO:0000250}.		cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]; neutrophil chemotaxis [GO:0030593]	basal plasma membrane [GO:0009925]; external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]; metal ion binding [GO:0046872]	basal plasma membrane [GO:0009925]; external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]; neutrophil chemotaxis [GO:0030593]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Q13813	reviewed	SPTN1_HUMAN	Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)	SPTAN1 NEAS SPTA2	Homo sapiens (Human)	2472	FUNCTION: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.		actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]	cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; spectrin [GO:0008091]; tertiary granule lumen [GO:1904724]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; structural constituent of cytoskeleton [GO:0005200]	cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; spectrin [GO:0008091]; tertiary granule lumen [GO:1904724]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; structural constituent of cytoskeleton [GO:0005200]; actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells. {ECO:0000250}.
Q13822	reviewed	ENPP2_HUMAN	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2) (EC 3.1.4.39) (Autotaxin) (Extracellular lysophospholipase D) (LysoPLD)	ENPP2 ATX PDNP2	Homo sapiens (Human)	863	FUNCTION: Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931, PubMed:14500380, PubMed:12354767). Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931, PubMed:14500380). Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:14500380). Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573). Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949). May have a role in induction of parturition (PubMed:12176993). Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor (PubMed:1733949, PubMed:11559573). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (PubMed:21393252). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:21393252). {ECO:0000269|PubMed:11559573, ECO:0000269|PubMed:12176993, ECO:0000269|PubMed:12354767, ECO:0000269|PubMed:14500380, ECO:0000269|PubMed:15769751, ECO:0000269|PubMed:1733949, ECO:0000269|PubMed:21240271, ECO:0000269|PubMed:21393252, ECO:0000269|PubMed:26371182, ECO:0000269|PubMed:27754931, ECO:0000305|PubMed:15700135}.		cell motility [GO:0048870]; chemotaxis [GO:0006935]; immune response [GO:0006955]; phosphatidylcholine catabolic process [GO:0034638]; phospholipid catabolic process [GO:0009395]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of cell migration [GO:0030334]; sphingolipid catabolic process [GO:0030149]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	alkylglycerophosphoethanolamine phosphodiesterase activity [GO:0047391]; calcium ion binding [GO:0005509]; hydrolase activity [GO:0016787]; lysophospholipase activity [GO:0004622]; nucleic acid binding [GO:0003676]; phosphodiesterase I activity [GO:0004528]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]; zinc ion binding [GO:0008270]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; alkylglycerophosphoethanolamine phosphodiesterase activity [GO:0047391]; calcium ion binding [GO:0005509]; hydrolase activity [GO:0016787]; lysophospholipase activity [GO:0004622]; nucleic acid binding [GO:0003676]; phosphodiesterase I activity [GO:0004528]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]; zinc ion binding [GO:0008270]; cell motility [GO:0048870]; chemotaxis [GO:0006935]; immune response [GO:0006955]; phosphatidylcholine catabolic process [GO:0034638]; phospholipid catabolic process [GO:0009395]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of cell migration [GO:0030334]; sphingolipid catabolic process [GO:0030149]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12176993, ECO:0000269|PubMed:15769751, ECO:0000269|PubMed:1733949, ECO:0000269|PubMed:26371182, ECO:0000269|PubMed:27754931}.
Q13823	reviewed	NOG2_HUMAN	Nucleolar GTP-binding protein 2 (Autoantigen NGP-1)	GNL2 NGP1	Homo sapiens (Human)	731	FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). {ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}.		ribosome biogenesis [GO:0042254]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:21495629}.
Q13825	reviewed	AUHM_HUMAN	Methylglutaconyl-CoA hydratase, mitochondrial (3-MG-CoA hydratase) (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding protein/enoyl-CoA hydratase) (Itaconyl-CoA hydratase) (EC 4.2.1.56)	AUH	Homo sapiens (Human)	339	FUNCTION: Catalyzes the fifth step in the leucine degradation pathway, the reversible hydration of 3-methylglutaconyl-CoA (3-MG-CoA) to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) (PubMed:12434311, PubMed:16640564, PubMed:11738050, PubMed:12655555). Can catalyze the reverse reaction but at a much lower rate in vitro (PubMed:16640564). HMG-CoA is then quickly degraded by another enzyme (such as HMG-CoA lyase) to give acetyl-CoA and acetoacetate (PubMed:16640564). Uses other substrates such as (2E)-glutaconyl-CoA efficiently in vitro, and to a lesser extent 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA), crotonyl-CoA ((2E)-butenoyl-CoA) and 3-hydroxybutanoyl-CoA (the missing carboxylate reduces affinity to the active site) (PubMed:16640564). Originally it was identified as an RNA-binding protein as it binds to AU-rich elements (AREs) in vitro (PubMed:7892223). AREs direct rapid RNA degradation and mRNA deadenylation (PubMed:7892223). Might have itaconyl-CoA hydratase activity, converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, an antimicrobial metabolite and immunomodulator produced by macrophages during certain infections, that can act as a vitamin B12-poisoning metabolite (PubMed:29056341). {ECO:0000269|PubMed:11738050, ECO:0000269|PubMed:12434311, ECO:0000269|PubMed:12655555, ECO:0000269|PubMed:16640564, ECO:0000269|PubMed:7892223, ECO:0000303|PubMed:16640564, ECO:0000303|PubMed:29056341}.		fatty acid beta-oxidation [GO:0006635]; leucine catabolic process [GO:0006552]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	enoyl-CoA hydratase activity [GO:0004300]; itaconyl-CoA hydratase activity [GO:0050011]; methylglutaconyl-CoA hydratase activity [GO:0004490]; mRNA 3'-UTR binding [GO:0003730]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; enoyl-CoA hydratase activity [GO:0004300]; itaconyl-CoA hydratase activity [GO:0050011]; methylglutaconyl-CoA hydratase activity [GO:0004490]; mRNA 3'-UTR binding [GO:0003730]; fatty acid beta-oxidation [GO:0006635]; leucine catabolic process [GO:0006552]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9JLZ3}.
Q13829	reviewed	BACD2_HUMAN	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial)	TNFAIP1 BACURD2 EDP1	Homo sapiens (Human)	316	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. {ECO:0000269|PubMed:19637314, ECO:0000269|PubMed:19782033}.		apoptotic process [GO:0006915]; cell migration [GO:0016477]; immune response [GO:0006955]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of DNA replication [GO:0045740]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; stress fiber assembly [GO:0043149]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleus [GO:0005634]	cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleus [GO:0005634]; cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; apoptotic process [GO:0006915]; cell migration [GO:0016477]; immune response [GO:0006955]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of DNA replication [GO:0045740]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; stress fiber assembly [GO:0043149]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes.
Q13835	reviewed	PKP1_HUMAN	Plakophilin-1 (Band 6 protein) (B6P)	PKP1	Homo sapiens (Human)	747	FUNCTION: Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis (PubMed:9326952). May facilitate the formation of intermediate filaments (PubMed:10852826). {ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:9326952}.		cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; intermediate filament bundle assembly [GO:0045110]; negative regulation of mRNA catabolic process [GO:1902373]; positive regulation of gene expression [GO:0010628]; signal transduction [GO:0007165]	adherens junction [GO:0005912]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; ficolin-1-rich granule membrane [GO:0101003]; intermediate filament [GO:0005882]; messenger ribonucleoprotein complex [GO:1990124]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; intermediate filament binding [GO:0019215]; lamin binding [GO:0005521]; structural constituent of skin epidermis [GO:0030280]	adherens junction [GO:0005912]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; ficolin-1-rich granule membrane [GO:0101003]; intermediate filament [GO:0005882]; messenger ribonucleoprotein complex [GO:1990124]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; intermediate filament binding [GO:0019215]; lamin binding [GO:0005521]; structural constituent of skin epidermis [GO:0030280]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; intermediate filament bundle assembly [GO:0045110]; negative regulation of mRNA catabolic process [GO:1902373]; positive regulation of gene expression [GO:0010628]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cell junction, desmosome {ECO:0000269|PubMed:9369526}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:9369526}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11790773}.
Q13838	reviewed	DX39B_HUMAN	Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein)	DDX39B BAT1 UAP56	Homo sapiens (Human)	428	FUNCTION: Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:15585580, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17562711, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}.		mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; RNA export from nucleus [GO:0006405]; RNA secondary structure unwinding [GO:0010501]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; viral mRNA export from host cell nucleus [GO:0046784]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; transcription export complex [GO:0000346]; U4 snRNP [GO:0005687]; U6 snRNP [GO:0005688]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent protein binding [GO:0043008]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; transcription export complex [GO:0000346]; U4 snRNP [GO:0005687]; U6 snRNP [GO:0005688]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent protein binding [GO:0043008]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; RNA export from nucleus [GO:0006405]; RNA secondary structure unwinding [GO:0010501]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; viral mRNA export from host cell nucleus [GO:0046784]	SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. Cytoplasm. Note=Can translocate to the cytoplasm in the presence of MX1. TREX complex assembly seems to occur in regions surrounding nuclear speckles known as perispeckles.
Q13867	reviewed	BLMH_HUMAN	Bleomycin hydrolase (BH) (BLM hydrolase) (BMH) (EC 3.4.22.40)	BLMH	Homo sapiens (Human)	455	FUNCTION: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. {ECO:0000250}.		homocysteine catabolic process [GO:0043418]; proteolysis [GO:0006508]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	aminopeptidase activity [GO:0004177]; carboxypeptidase activity [GO:0004180]; cysteine-type aminopeptidase activity [GO:0070005]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; aminopeptidase activity [GO:0004177]; carboxypeptidase activity [GO:0004180]; cysteine-type aminopeptidase activity [GO:0070005]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; identical protein binding [GO:0042802]; homocysteine catabolic process [GO:0043418]; proteolysis [GO:0006508]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31875550}. Cytoplasmic granule {ECO:0000269|PubMed:31875550}. Note=Co-localizes with NUDT12 in the cytoplasmic granules. {ECO:0000269|PubMed:31875550}.
Q13868	reviewed	EXOS2_HUMAN	Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4)	EXOSC2 RRP4	Homo sapiens (Human)	293	FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7. {ECO:0000269|PubMed:17545563}.		CUT catabolic process [GO:0071034]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5'-RNA exonuclease activity [GO:0000175]; 7S RNA binding [GO:0008312]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5'-RNA exonuclease activity [GO:0000175]; 7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; CUT catabolic process [GO:0071034]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Nucleus.
Q13873	reviewed	BMPR2_HUMAN	Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)	BMPR2 PPH1	Homo sapiens (Human)	1038	FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. {ECO:0000250|UniProtKB:O35607}.		anterior/posterior pattern specification [GO:0009952]; aortic valve development [GO:0003176]; artery development [GO:0060840]; atrial septum morphogenesis [GO:0060413]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; cellular response to starvation [GO:0009267]; chondrocyte development [GO:0002063]; endocardial cushion development [GO:0003197]; endochondral bone morphogenesis [GO:0060350]; endothelial cell apoptotic process [GO:0072577]; endothelial cell proliferation [GO:0001935]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; lung vasculature development [GO:0060426]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; maternal placenta development [GO:0001893]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation involved in heart valve morphogenesis [GO:0003252]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of vasoconstriction [GO:0045906]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; phosphorylation [GO:0016310]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteoglycan biosynthetic process [GO:0030166]; pulmonary valve development [GO:0003177]; regulation of cell population proliferation [GO:0042127]; regulation of lung blood pressure [GO:0014916]; retina vasculature development in camera-type eye [GO:0061298]; semi-lunar valve development [GO:1905314]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; tricuspid valve morphogenesis [GO:0003186]; venous blood vessel development [GO:0060841]; ventricular septum morphogenesis [GO:0060412]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; basal plasma membrane [GO:0009925]; caveola [GO:0005901]; cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; receptor complex [GO:0043235]	activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]; cadherin binding [GO:0045296]; growth factor binding [GO:0019838]; metal ion binding [GO:0046872]; protein tyrosine kinase binding [GO:1990782]; transforming growth factor beta receptor activity [GO:0005024]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; basal plasma membrane [GO:0009925]; caveola [GO:0005901]; cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; receptor complex [GO:0043235]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]; cadherin binding [GO:0045296]; growth factor binding [GO:0019838]; metal ion binding [GO:0046872]; protein tyrosine kinase binding [GO:1990782]; transforming growth factor beta receptor activity [GO:0005024]; anterior/posterior pattern specification [GO:0009952]; aortic valve development [GO:0003176]; artery development [GO:0060840]; atrial septum morphogenesis [GO:0060413]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; cellular response to starvation [GO:0009267]; chondrocyte development [GO:0002063]; endocardial cushion development [GO:0003197]; endochondral bone morphogenesis [GO:0060350]; endothelial cell apoptotic process [GO:0072577]; endothelial cell proliferation [GO:0001935]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; lung vasculature development [GO:0060426]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; maternal placenta development [GO:0001893]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation involved in heart valve morphogenesis [GO:0003252]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of vasoconstriction [GO:0045906]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; phosphorylation [GO:0016310]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteoglycan biosynthetic process [GO:0030166]; pulmonary valve development [GO:0003177]; regulation of cell population proliferation [GO:0042127]; regulation of lung blood pressure [GO:0014916]; retina vasculature development in camera-type eye [GO:0061298]; semi-lunar valve development [GO:1905314]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; tricuspid valve morphogenesis [GO:0003186]; venous blood vessel development [GO:0060841]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25187962}; Single-pass type I membrane protein.
Q13875	reviewed	MOBP_HUMAN	Myelin-associated oligodendrocyte basic protein	MOBP	Homo sapiens (Human)	183	FUNCTION: May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane. {ECO:0000250}.		central nervous system myelin formation [GO:0032289]; nervous system development [GO:0007399]	mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]	structural constituent of myelin sheath [GO:0019911]	mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; structural constituent of myelin sheath [GO:0019911]; central nervous system myelin formation [GO:0032289]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Note=Present in the major dense line of CNS myelin. {ECO:0000250}.
Q13882	reviewed	PTK6_HUMAN	Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK)	PTK6 BRK	Homo sapiens (Human)	451	FUNCTION: Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.; FUNCTION: Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.	MISCELLANEOUS: The inhibitors bind to the ATP-binding pocket. {ECO:0000269|PubMed:27993680}.	cell differentiation [GO:0030154]; cell migration [GO:0016477]; cellular response to retinoic acid [GO:0071300]; ERBB2 signaling pathway [GO:0038128]; innate immune response [GO:0045087]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of growth [GO:0045926]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of cell cycle [GO:0045787]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of neuron projection development [GO:0010976]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; tyrosine phosphorylation of STAT protein [GO:0007260]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cellular response to retinoic acid [GO:0071300]; ERBB2 signaling pathway [GO:0038128]; innate immune response [GO:0045087]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of growth [GO:0045926]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of cell cycle [GO:0045787]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of neuron projection development [GO:0010976]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; tyrosine phosphorylation of STAT protein [GO:0007260]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell projection, ruffle. Membrane {ECO:0000250}. Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.
Q13884	reviewed	SNTB1_HUMAN	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43)	SNTB1 SNT2B1	Homo sapiens (Human)	538	FUNCTION: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.		muscle contraction [GO:0006936]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202]	actin binding [GO:0003779]; calmodulin binding [GO:0005516]; PDZ domain binding [GO:0030165]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202]; actin binding [GO:0003779]; calmodulin binding [GO:0005516]; PDZ domain binding [GO:0030165]; structural molecule activity [GO:0005198]; muscle contraction [GO:0006936]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions. {ECO:0000250}.
Q13885	reviewed	TBB2A_HUMAN	Tubulin beta-2A chain (Tubulin beta class IIa)	TUBB2A TUBB2	Homo sapiens (Human)	445	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q13886	reviewed	KLF9_HUMAN	Krueppel-like factor 9 (Basic transcription element-binding protein 1) (BTE-binding protein 1) (GC-box-binding protein 1) (Transcription factor BTEB1)	KLF9 BTEB BTEB1	Homo sapiens (Human)	244	FUNCTION: Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835). {ECO:0000269|PubMed:22711835}.		cellular response to cortisol stimulus [GO:0071387]; cellular response to thyroid hormone stimulus [GO:0097067]; circadian rhythm [GO:0007623]; negative regulation of keratinocyte proliferation [GO:0010839]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cellular response to cortisol stimulus [GO:0071387]; cellular response to thyroid hormone stimulus [GO:0097067]; circadian rhythm [GO:0007623]; negative regulation of keratinocyte proliferation [GO:0010839]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22711835}.
Q13887	reviewed	KLF5_HUMAN	Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)	KLF5 BTEB2 CKLF IKLF	Homo sapiens (Human)	457	FUNCTION: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.		angiogenesis [GO:0001525]; cell-cell signaling via exosome [GO:0099156]; cellular response to leukemia inhibitory factor [GO:1990830]; intestinal epithelial cell development [GO:0060576]; microvillus assembly [GO:0030033]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by transcription factor localization [GO:0061586]; regulation of microvillus assembly [GO:0032534]; regulation of transcription by RNA polymerase II [GO:0006357]; satellite cell activation involved in skeletal muscle regeneration [GO:0014901]; skeletal muscle satellite cell differentiation [GO:0014816]	chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; MRF binding [GO:0043426]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; MRF binding [GO:0043426]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; angiogenesis [GO:0001525]; cell-cell signaling via exosome [GO:0099156]; cellular response to leukemia inhibitory factor [GO:1990830]; intestinal epithelial cell development [GO:0060576]; microvillus assembly [GO:0030033]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by transcription factor localization [GO:0061586]; regulation of microvillus assembly [GO:0032534]; regulation of transcription by RNA polymerase II [GO:0006357]; satellite cell activation involved in skeletal muscle regeneration [GO:0014901]; skeletal muscle satellite cell differentiation [GO:0014816]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15735697}.
Q13888	reviewed	TF2H2_HUMAN	General transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit)	GTF2H2 BTF2P44	Homo sapiens (Human)	395	FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. {ECO:0000269|PubMed:11319235, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:8194529, ECO:0000269|PubMed:9852112}.		G protein-coupled receptor internalization [GO:0002031]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA helicase activity [GO:1905776]; regulation of transcription by RNA polymerase II [GO:0006357]; response to UV [GO:0009411]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	core TFIIH complex portion of holo TFIIH complex [GO:0000438]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]	RNA polymerase II general transcription initiation factor activity [GO:0016251]; zinc ion binding [GO:0008270]	core TFIIH complex portion of holo TFIIH complex [GO:0000438]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; zinc ion binding [GO:0008270]; G protein-coupled receptor internalization [GO:0002031]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA helicase activity [GO:1905776]; regulation of transcription by RNA polymerase II [GO:0006357]; response to UV [GO:0009411]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27193682}.
Q13889	reviewed	TF2H3_HUMAN	General transcription factor IIH subunit 3 (Basic transcription factor 2 34 kDa subunit) (BTF2 p34) (General transcription factor IIH polypeptide 3) (TFIIH basal transcription factor complex p34 subunit)	GTF2H3	Homo sapiens (Human)	308	FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000269|PubMed:9852112}.		DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]	core TFIIH complex portion of holo TFIIH complex [GO:0000438]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription preinitiation complex [GO:0097550]	metal ion binding [GO:0046872]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	core TFIIH complex portion of holo TFIIH complex [GO:0000438]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription preinitiation complex [GO:0097550]; metal ion binding [GO:0046872]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:9852112}.
Q13895	reviewed	BYST_HUMAN	Bystin	BYSL ENP1	Homo sapiens (Human)	437	FUNCTION: Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. {ECO:0000269|PubMed:17360433, ECO:0000269|PubMed:17381424}.	MISCELLANEOUS: HeLa cells lacking BYSL show a delay in the processing of the 18S rRNA component of the 40S ribosomal subunit. HT-H cells lacking BYSL show trophinin-independent signaling through ERBB4.	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of protein localization to nucleolus [GO:1904749]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; stem cell proliferation [GO:0072089]; trophectodermal cell differentiation [GO:0001829]	apical part of cell [GO:0045177]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]	RNA binding [GO:0003723]; snoRNA binding [GO:0030515]	apical part of cell [GO:0045177]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of protein localization to nucleolus [GO:1904749]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; stem cell proliferation [GO:0072089]; trophectodermal cell differentiation [GO:0001829]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17381424}. Nucleus, nucleolus {ECO:0000269|PubMed:17381424, ECO:0000269|PubMed:26711351}. Note=Associated with 40S ribosomal subunits.
Q13901	reviewed	C1D_HUMAN	Nuclear nucleic acid-binding protein C1D (hC1D)	C1D	Homo sapiens (Human)	141	FUNCTION: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). {ECO:0000250, ECO:0000269|PubMed:10362552, ECO:0000269|PubMed:11801738, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:9679063}.		apoptotic process [GO:0006915]; maturation of 5.8S rRNA [GO:0000460]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA binding [GO:0003677]; nuclear receptor binding [GO:0016922]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA binding [GO:0003677]; nuclear receptor binding [GO:0016922]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; apoptotic process [GO:0006915]; maturation of 5.8S rRNA [GO:0000460]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11801738}. Cytoplasm {ECO:0000269|PubMed:11801738}. Nucleus, nucleolus {ECO:0000269|PubMed:17412707}. Note=EXOSC10 is required for nucleolar localization (PubMed:17412707). Colocalizes with TSNAX in the nucleus (PubMed:11801738). {ECO:0000269|PubMed:11801738, ECO:0000269|PubMed:17412707}.
Q13905	reviewed	RPGF1_HUMAN	Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)	RAPGEF1 GRF2	Homo sapiens (Human)	1077	FUNCTION: Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}.		cellular response to cAMP [GO:0071320]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of cell junction assembly [GO:1901888]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124]; cellular response to cAMP [GO:0071320]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of cell junction assembly [GO:1901888]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:17724123}.
Q13907	reviewed	IDI1_HUMAN	Isopentenyl-diphosphate Delta-isomerase 1 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 1) (IPP isomerase 1) (IPPI1)	IDI1	Homo sapiens (Human)	227	FUNCTION: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). {ECO:0000269|PubMed:8806705}.		cholesterol biosynthetic process [GO:0006695]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isopentenyl diphosphate biosynthetic process [GO:0009240]; isoprenoid biosynthetic process [GO:0008299]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisome [GO:0005777]	isopentenyl-diphosphate delta-isomerase activity [GO:0004452]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisome [GO:0005777]; isopentenyl-diphosphate delta-isomerase activity [GO:0004452]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; cholesterol biosynthetic process [GO:0006695]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isopentenyl diphosphate biosynthetic process [GO:0009240]; isoprenoid biosynthetic process [GO:0008299]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:O35586}.
Q13936	reviewed	CAC1C_HUMAN	Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)	CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1	Homo sapiens (Human)	2221	FUNCTION: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:23677916, PubMed:30023270, PubMed:30172029, PubMed:34163037). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:11741969, ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17071743, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:23677916, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:28119464, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:30023270, ECO:0000269|PubMed:30172029, ECO:0000269|PubMed:34163037, ECO:0000269|PubMed:7737988, ECO:0000269|PubMed:8099908, ECO:0000269|PubMed:8392192, ECO:0000269|PubMed:9013606, ECO:0000269|PubMed:9087614, ECO:0000269|PubMed:9607315, ECO:0000305}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269|PubMed:29779930}.	MISCELLANEOUS: [Isoform 3]: Contains exon 8a. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Lacks exon 21. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Lacks exon 22. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Lacks exon 31. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Lacks exon 32. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Lacks exon 33. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Contains exon 40B and 43A. {ECO:0000305}.; MISCELLANEOUS: [Isoform 10]: Contains exon 41A. {ECO:0000305}.; MISCELLANEOUS: [Isoform 11]: Lacks exon 45. {ECO:0000305}.; MISCELLANEOUS: [Isoform 20]: Predominant isoform in atherosclerotic vascular smooth muscle cells. {ECO:0000305}.; MISCELLANEOUS: [Isoform 26]: Not inhibited by calcium. {ECO:0000305}.; MISCELLANEOUS: [Isoform 34]: Enhanced by PKC activator. {ECO:0000305}.	calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport into cytosol [GO:0060402]; calcium-mediated signaling using extracellular calcium source [GO:0035585]; camera-type eye development [GO:0043010]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; embryonic forelimb morphogenesis [GO:0035115]; heart development [GO:0007507]; immune system development [GO:0002520]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; L-type voltage-gated calcium channel complex [GO:1990454]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018]	alpha-actinin binding [GO:0051393]; calmodulin binding [GO:0005516]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in AV node cell action potential [GO:0086056]; voltage-gated calcium channel activity involved in cardiac muscle cell action potential [GO:0086007]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; L-type voltage-gated calcium channel complex [GO:1990454]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018]; alpha-actinin binding [GO:0051393]; calmodulin binding [GO:0005516]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in AV node cell action potential [GO:0086056]; voltage-gated calcium channel activity involved in cardiac muscle cell action potential [GO:0086007]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport into cytosol [GO:0060402]; calcium-mediated signaling using extracellular calcium source [GO:0035585]; camera-type eye development [GO:0043010]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; embryonic forelimb morphogenesis [GO:0035115]; heart development [GO:0007507]; immune system development [GO:0002520]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11741969, ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17071743, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:7737988, ECO:0000269|PubMed:8099908, ECO:0000269|PubMed:8392192, ECO:0000269|PubMed:9013606, ECO:0000269|PubMed:9087614, ECO:0000269|PubMed:9607315}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P15381}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:P22002}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P22002}. Cell projection, dendrite {ECO:0000250|UniProtKB:P22002}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:Q01815}. Note=Colocalizes with ryanodine receptors in distinct clusters at the junctional membrane, where the sarcolemma and the sarcoplasmic reticulum are in close contact. The interaction between RRAD and CACNB2 promotes the expression of CACNA1C at the cell membrane. {ECO:0000250|UniProtKB:P15381}.
Q13938	reviewed	CAYP1_HUMAN	Calcyphosin (Calcyphosine)	CAPS	Homo sapiens (Human)	275	FUNCTION: Calcium-binding protein. May play a role in cellular signaling events (Potential). {ECO:0000305}.		intracellular signal transduction [GO:0035556]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	calcium ion binding [GO:0005509]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; calcium ion binding [GO:0005509]; intracellular signal transduction [GO:0035556]	SUBCELLULAR LOCATION: Cytoplasm.
Q13946	reviewed	PDE7A_HUMAN	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22)	PDE7A	Homo sapiens (Human)	482	FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:8389765, PubMed:9195912, PubMed:19350606). May have a role in muscle signal transduction (PubMed:9195912). {ECO:0000269|PubMed:19350606, ECO:0000269|PubMed:8389765, ECO:0000269|PubMed:9195912}.		cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]	cytosol [GO:0005829]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]; cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]	SUBCELLULAR LOCATION: [Isoform PDE7A1]: Cytoplasm, cytosol {ECO:0000269|PubMed:9195912}. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions. {ECO:0000269|PubMed:9195912}.; SUBCELLULAR LOCATION: [Isoform PDE7A2]: Cytoplasm {ECO:0000269|PubMed:9195912}. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions. {ECO:0000269|PubMed:9195912}.
Q13948	reviewed	CASP_HUMAN	Protein CASP	CUX1 CUTL1	Homo sapiens (Human)	678	FUNCTION: May be involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:15718469}.		intra-Golgi vesicle-mediated transport [GO:0006891]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]		Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; intra-Golgi vesicle-mediated transport [GO:0006891]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12429822}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12429822}.
Q13950	reviewed	RUNX2_HUMAN	Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)	RUNX2 AML3 CBFA1 OSF2 PEBP2A	Homo sapiens (Human)	521	FUNCTION: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28738062, PubMed:28703881). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}.		BMP signaling pathway [GO:0030509]; cell maturation [GO:0048469]; cellular response to BMP stimulus [GO:0071773]; chondrocyte development [GO:0002063]; chondrocyte differentiation [GO:0002062]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; endochondral ossification [GO:0001958]; epithelial cell proliferation [GO:0050673]; gene expression [GO:0010467]; hemopoiesis [GO:0030097]; ligamentous ossification [GO:0036076]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of smoothened signaling pathway [GO:0045879]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; ossification [GO:0001503]; osteoblast development [GO:0002076]; osteoblast differentiation [GO:0001649]; osteoblast fate commitment [GO:0002051]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; regulation of cell differentiation [GO:0045595]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of ossification [GO:0030278]; regulation of transcription by RNA polymerase II [GO:0006357]; response to L-ascorbic acid [GO:0033591]; response to sodium phosphate [GO:1904383]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; T cell differentiation [GO:0030217]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	ATP binding [GO:0005524]; bHLH transcription factor binding [GO:0043425]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ATP binding [GO:0005524]; bHLH transcription factor binding [GO:0043425]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; BMP signaling pathway [GO:0030509]; cell maturation [GO:0048469]; cellular response to BMP stimulus [GO:0071773]; chondrocyte development [GO:0002063]; chondrocyte differentiation [GO:0002062]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; endochondral ossification [GO:0001958]; epithelial cell proliferation [GO:0050673]; gene expression [GO:0010467]; hemopoiesis [GO:0030097]; ligamentous ossification [GO:0036076]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of smoothened signaling pathway [GO:0045879]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; ossification [GO:0001503]; osteoblast development [GO:0002076]; osteoblast differentiation [GO:0001649]; osteoblast fate commitment [GO:0002051]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; regulation of cell differentiation [GO:0045595]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of ossification [GO:0030278]; regulation of transcription by RNA polymerase II [GO:0006357]; response to L-ascorbic acid [GO:0033591]; response to sodium phosphate [GO:1904383]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28738062}. Cytoplasm {ECO:0000250|UniProtKB:Q08775}.
Q13951	reviewed	PEBB_HUMAN	Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)	CBFB	Homo sapiens (Human)	182	FUNCTION: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. {ECO:0000250|UniProtKB:Q08024}.		cell maturation [GO:0048469]; definitive hemopoiesis [GO:0060216]; lymphocyte differentiation [GO:0030098]; myeloid cell differentiation [GO:0030099]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein polyubiquitination [GO:0000209]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	core-binding factor complex [GO:0016513]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]	core-binding factor complex [GO:0016513]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; cell maturation [GO:0048469]; definitive hemopoiesis [GO:0060216]; lymphocyte differentiation [GO:0030098]; myeloid cell differentiation [GO:0030099]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein polyubiquitination [GO:0000209]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q13952	reviewed	NFYC_HUMAN	Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC) (Transactivator HSM-1/2)	NFYC	Homo sapiens (Human)	458	FUNCTION: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.		positive regulation of transcription by RNA polymerase II [GO:0045944]; protein folding [GO:0006457]; regulation of DNA-templated transcription [GO:0006355]; regulation of histone acetylation [GO:0035065]; regulation of transcription by RNA polymerase II [GO:0006357]	CCAAT-binding factor complex [GO:0016602]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	CCAAT-binding factor complex [GO:0016602]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein folding [GO:0006457]; regulation of DNA-templated transcription [GO:0006355]; regulation of histone acetylation [GO:0035065]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q13956	reviewed	CNCG_HUMAN	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (GMP-PDE gamma) (EC 3.1.4.35)	PDE6H	Homo sapiens (Human)	83	FUNCTION: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.		positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of MAPK cascade [GO:0043410]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	photoreceptor outer segment membrane [GO:0042622]	3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cGMP binding [GO:0030553]; enzyme inhibitor activity [GO:0004857]	photoreceptor outer segment membrane [GO:0042622]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cGMP binding [GO:0030553]; enzyme inhibitor activity [GO:0004857]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of MAPK cascade [GO:0043410]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	
Q13972	reviewed	RGRF1_HUMAN	Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25)	RASGRF1 CDC25 GNRP GRF1	Homo sapiens (Human)	1273	FUNCTION: Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000269|PubMed:11389730}.		activation of GTPase activity [GO:0090630]; long-term memory [GO:0007616]; neuron projection development [GO:0031175]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of Rac protein signal transduction [GO:0035020]; regulation of Ras protein signal transduction [GO:0046578]; regulation of synaptic plasticity [GO:0048167]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; type B pancreatic cell proliferation [GO:0044342]	cytosol [GO:0005829]; growth cone [GO:0030426]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	glutamate receptor binding [GO:0035254]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; growth cone [GO:0030426]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; glutamate receptor binding [GO:0035254]; guanyl-nucleotide exchange factor activity [GO:0005085]; activation of GTPase activity [GO:0090630]; long-term memory [GO:0007616]; neuron projection development [GO:0031175]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of Rac protein signal transduction [GO:0035020]; regulation of Ras protein signal transduction [GO:0046578]; regulation of synaptic plasticity [GO:0048167]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; type B pancreatic cell proliferation [GO:0044342]	
Q13976	reviewed	KGP1_HUMAN	cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI)	PRKG1 PRKG1B PRKGR1A PRKGR1B	Homo sapiens (Human)	671	FUNCTION: Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269|PubMed:10567269, ECO:0000269|PubMed:11162591, ECO:0000269|PubMed:11723116, ECO:0000269|PubMed:12082086, ECO:0000269|PubMed:14608379, ECO:0000269|PubMed:15194681, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:8182057}.	MISCELLANEOUS: The 3D structures in complex with cGMP and cAMP describe the hydrogen bonding interactions that modulate high selectivity for cGMP in the CNB-B domain, and reveal that all these contacts are disrupted in the structure with cAMP, explaining the low affinity of the enzyme for cAMP and the fact that cAMP can only weakly activate PKG. {ECO:0000269|PubMed:25271401}.	actin cytoskeleton organization [GO:0030036]; cell growth involved in cardiac muscle cell development [GO:0061049]; cerebellum development [GO:0021549]; cGMP-mediated signaling [GO:0019934]; collateral sprouting [GO:0048668]; dendrite development [GO:0016358]; forebrain development [GO:0030900]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of inositol phosphate biosynthetic process [GO:0010920]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; neuron migration [GO:0001764]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein phosphorylation [GO:0006468]; regulation of GTPase activity [GO:0043087]; regulation of testosterone biosynthetic process [GO:2000224]; relaxation of vascular associated smooth muscle [GO:0060087]; signal transduction [GO:0007165]; spermatid development [GO:0007286]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; cGMP binding [GO:0030553]; cGMP-dependent protein kinase activity [GO:0004692]; identical protein binding [GO:0042802]; mitogen-activated protein kinase p38 binding [GO:0048273]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; cGMP binding [GO:0030553]; cGMP-dependent protein kinase activity [GO:0004692]; identical protein binding [GO:0042802]; mitogen-activated protein kinase p38 binding [GO:0048273]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; actin cytoskeleton organization [GO:0030036]; cell growth involved in cardiac muscle cell development [GO:0061049]; cerebellum development [GO:0021549]; cGMP-mediated signaling [GO:0019934]; collateral sprouting [GO:0048668]; dendrite development [GO:0016358]; forebrain development [GO:0030900]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of inositol phosphate biosynthetic process [GO:0010920]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; neuron migration [GO:0001764]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein phosphorylation [GO:0006468]; regulation of GTPase activity [GO:0043087]; regulation of testosterone biosynthetic process [GO:2000224]; relaxation of vascular associated smooth muscle [GO:0060087]; signal transduction [GO:0007165]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Colocalized with TRPC7 in the plasma membrane. {ECO:0000250}.
Q14002	reviewed	CEAM7_HUMAN	Carcinoembryonic antigen-related cell adhesion molecule 7 (CEA cell adhesion molecule 7) (Carcinoembryonic antigen CGM2)	CEACAM7 CGM2	Homo sapiens (Human)	265			regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	protein tyrosine kinase binding [GO:1990782]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; protein tyrosine kinase binding [GO:1990782]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:10436421}. Note=Localized to the apical glycocalyx surface. {ECO:0000269|PubMed:10436421}.
Q14003	reviewed	KCNC3_HUMAN	Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3)	KCNC3	Homo sapiens (Human)	757	FUNCTION: Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484). {ECO:0000250|UniProtKB:Q63959, ECO:0000269|PubMed:10712820, ECO:0000269|PubMed:16501573, ECO:0000269|PubMed:19953606, ECO:0000269|PubMed:21479265, ECO:0000269|PubMed:22289912, ECO:0000269|PubMed:23734863, ECO:0000269|PubMed:25756792, ECO:0000269|PubMed:26997484}.		potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; protein tetramerization [GO:0051262]; regulation of monoatomic ion transmembrane transport [GO:0034765]	axon terminus [GO:0043679]; cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; dendrite membrane [GO:0032590]; dendritic spine membrane [GO:0032591]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; dendrite membrane [GO:0032590]; dendritic spine membrane [GO:0032591]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; protein tetramerization [GO:0051262]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10712820, ECO:0000269|PubMed:16501573, ECO:0000269|PubMed:19953606, ECO:0000269|PubMed:21479265, ECO:0000269|PubMed:22289912, ECO:0000269|PubMed:23734863, ECO:0000269|PubMed:25152487, ECO:0000269|PubMed:25756792, ECO:0000269|PubMed:26997484}; Multi-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q63959}; Multi-pass membrane protein {ECO:0000255}. Perikaryon {ECO:0000250|UniProtKB:Q63959}. Cell projection, axon {ECO:0000250|UniProtKB:Q63959}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63959}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q01956}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cell cortex {ECO:0000269|PubMed:26997484}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26997484}. Note=Detected on Purkinje cell dendritic spines, positioned perisynaptically but also in extrasynaptic positions along the spine membranes (By similarity). Detected at presynaptic calices of Held (By similarity). Colocalizes with the cortical actin cytoskeleton and the Arp2/3 complex (PubMed:26997484). {ECO:0000250|UniProtKB:Q01956, ECO:0000250|UniProtKB:Q63959, ECO:0000269|PubMed:26997484}.
Q14004	reviewed	CDK13_HUMAN	Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller)	CDK13 CDC2L CDC2L5 CHED KIAA1791	Homo sapiens (Human)	1512	FUNCTION: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.		alternative mRNA splicing, via spliceosome [GO:0000380]; hemopoiesis [GO:0030097]; negative regulation of stem cell differentiation [GO:2000737]; phosphorylation [GO:0016310]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of signal transduction [GO:0009966]	cyclin K-CDK13 complex [GO:0002945]; cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]	cyclin K-CDK13 complex [GO:0002945]; cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; alternative mRNA splicing, via spliceosome [GO:0000380]; hemopoiesis [GO:0030097]; negative regulation of stem cell differentiation [GO:2000737]; phosphorylation [GO:0016310]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:16721827}.
Q14005	reviewed	IL16_HUMAN	Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]	IL16	Homo sapiens (Human)	1332	FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage. Is probably proteolytically processed to yield IL-16.; MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing of isoform 1. Is probably proteolytically processed to yield IL-16. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. Is proteolytically processed to yield IL-16. {ECO:0000305}.	immune response [GO:0006955]; induction of positive chemotaxis [GO:0050930]; leukocyte chemotaxis [GO:0030595]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; regulation of calcium ion transport [GO:0051924]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]	CD4 receptor binding [GO:0042609]; cytokine activity [GO:0005125]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; CD4 receptor binding [GO:0042609]; cytokine activity [GO:0005125]; immune response [GO:0006955]; induction of positive chemotaxis [GO:0050930]; leukocyte chemotaxis [GO:0030595]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; regulation of calcium ion transport [GO:0051924]	SUBCELLULAR LOCATION: [Interleukin-16]: Secreted.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.
Q14008	reviewed	CKAP5_HUMAN	Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG)	CKAP5 KIAA0097	Homo sapiens (Human)	2032	FUNCTION: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}.		cell division [GO:0051301]; centrosome cycle [GO:0007098]; centrosome duplication [GO:0051298]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; microtubule depolymerization [GO:0007019]; microtubule polymerization [GO:0046785]; mitotic spindle organization [GO:0007052]; positive regulation of microtubule nucleation [GO:0090063]; RNA transport [GO:0050658]; spindle organization [GO:0007051]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]	cadherin binding [GO:0045296]; microtubule binding [GO:0008017]; microtubule plus end polymerase [GO:0061863]; microtubule plus-end binding [GO:0051010]; ribonucleoprotein complex binding [GO:0043021]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]; cadherin binding [GO:0045296]; microtubule binding [GO:0008017]; microtubule plus end polymerase [GO:0061863]; microtubule plus-end binding [GO:0051010]; ribonucleoprotein complex binding [GO:0043021]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; centrosome duplication [GO:0051298]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; microtubule depolymerization [GO:0007019]; microtubule polymerization [GO:0046785]; mitotic spindle organization [GO:0007052]; positive regulation of microtubule nucleation [GO:0090063]; RNA transport [GO:0050658]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:25596274, ECO:0000269|PubMed:9570755}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:21646404}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:25596274, ECO:0000269|PubMed:9570755}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:25596274}. Note=Detected on centrosomes and kinetochores during interphase and mitosis independently from TACC3 and clathrin. Located to spindle poles and microtubules during mitosis. In complex with TACC3 localized to microtubule plus-ends in mitosis and interphase. In complex with TACC3 and clathrin localized to inter-microtubule bridges in mitotic spindles. Accumulation sites at microtubule plus ends protruded approximately 100 nm from MAPRE1/EB1 sites in interphase cells. {ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23251535, ECO:0000269|PubMed:25596274}.
Q14011	reviewed	CIRBP_HUMAN	Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP)	CIRBP A18HNRNP CIRP	Homo sapiens (Human)	172	FUNCTION: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. {ECO:0000250, ECO:0000269|PubMed:11574538, ECO:0000269|PubMed:16513844}.		mRNA stabilization [GO:0048255]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of translation [GO:0045727]; response to cold [GO:0009409]; response to UV [GO:0009411]; stress granule assembly [GO:0034063]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; translation repressor activity [GO:0030371]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; translation repressor activity [GO:0030371]; mRNA stabilization [GO:0048255]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of translation [GO:0045727]; response to cold [GO:0009409]; response to UV [GO:0009411]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:11574538}. Cytoplasm {ECO:0000269|PubMed:11574538}. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). {ECO:0000250}.
Q14012	reviewed	KCC1A_HUMAN	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha)	CAMK1	Homo sapiens (Human)	370	FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. {ECO:0000250, ECO:0000269|PubMed:11114197, ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:14507913, ECO:0000269|PubMed:14754892, ECO:0000269|PubMed:17056143, ECO:0000269|PubMed:17442826, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:20181577}.		cell cycle [GO:0007049]; cell differentiation [GO:0030154]; negative regulation of protein binding [GO:0032091]; nervous system development [GO:0007399]; nucleocytoplasmic transport [GO:0006913]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of synapse structural plasticity [GO:0051835]; positive regulation of syncytium formation by plasma membrane fusion [GO:0060143]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of muscle cell differentiation [GO:0051147]; regulation of protein binding [GO:0043393]; regulation of protein localization [GO:0032880]; signal transduction [GO:0007165]	cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]	cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; negative regulation of protein binding [GO:0032091]; nervous system development [GO:0007399]; nucleocytoplasmic transport [GO:0006913]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of synapse structural plasticity [GO:0051835]; positive regulation of syncytium formation by plasma membrane fusion [GO:0060143]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of muscle cell differentiation [GO:0051147]; regulation of protein binding [GO:0043393]; regulation of protein localization [GO:0032880]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. {ECO:0000250}.
Q14019	reviewed	COTL1_HUMAN	Coactosin-like protein	COTL1 CLP	Homo sapiens (Human)	142	FUNCTION: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. {ECO:0000269|PubMed:11583571, ECO:0000269|PubMed:19807693}.		defense response to fungus [GO:0050832]; regulation of actin filament polymerization [GO:0030833]	cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; site of polarized growth [GO:0030427]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; enzyme binding [GO:0019899]	cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; site of polarized growth [GO:0030427]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; enzyme binding [GO:0019899]; defense response to fungus [GO:0050832]; regulation of actin filament polymerization [GO:0030833]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11583571}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11583571}. Nucleus {ECO:0000269|PubMed:19807693}.
Q14028	reviewed	CNGB1_HUMAN	Cyclic nucleotide-gated cation channel beta-1 (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel beta-1) (CNG channel beta-1) (Glutamic acid-rich protein) (GARP)	CNGB1 CNCG2 CNCG3L CNCG4 RCNC2	Homo sapiens (Human)	1251	FUNCTION: Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.; FUNCTION: Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.	MISCELLANEOUS: [Isoform GARP2]: In the rod cells, the CNGB1 locus encodes the cyclic nucleotide-gated cation channel beta-1 subunit and several glutamic-acid-rich proteins (GARPs). {ECO:0000305}.	detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; detection of light stimulus involved in visual perception [GO:0050908]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; membrane depolarization [GO:0051899]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; olfactory nerve maturation [GO:0021630]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; protein localization to organelle [GO:0033365]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to odorant [GO:1990834]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]	ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; terminal bouton [GO:0043195]; transmembrane transporter complex [GO:1902495]	cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; protein-containing complex binding [GO:0044877]	ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; terminal bouton [GO:0043195]; transmembrane transporter complex [GO:1902495]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; protein-containing complex binding [GO:0044877]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; detection of light stimulus involved in visual perception [GO:0050908]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; membrane depolarization [GO:0051899]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; olfactory nerve maturation [GO:0021630]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; protein localization to organelle [GO:0033365]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to odorant [GO:1990834]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q14031	reviewed	CO4A6_HUMAN	Collagen alpha-6(IV) chain	COL4A6	Homo sapiens (Human)	1691	FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.		cell adhesion [GO:0007155]; cellular response to amino acid stimulus [GO:0071230]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; extracellular matrix organization [GO:0030198]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; cell adhesion [GO:0007155]; cellular response to amino acid stimulus [GO:0071230]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
Q14032	reviewed	BAAT_HUMAN	Bile acid-CoA:amino acid N-acyltransferase (BACAT) (BAT) (EC 2.3.1.65) (Bile acid-CoA thioesterase) (Choloyl-CoA hydrolase) (EC 3.1.2.27) (Glycine N-choloyltransferase) (Long-chain fatty-acyl-CoA hydrolase) (EC 3.1.2.2)	BAAT	Homo sapiens (Human)	418	FUNCTION: Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine (PubMed:12810727, PubMed:8034703, PubMed:2037576, PubMed:12239217). More than 95% of the BAs are N-acyl amidates with glycine and taurine (PubMed:8034703). Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (PubMed:12810727). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (PubMed:12810727). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (PubMed:12810727, PubMed:8034703, PubMed:12239217). In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (PubMed:12810727). {ECO:0000269|PubMed:12239217, ECO:0000269|PubMed:12810727, ECO:0000269|PubMed:2037576, ECO:0000269|PubMed:8034703, ECO:0000303|PubMed:12810727, ECO:0000303|PubMed:8034703}.		acyl-CoA metabolic process [GO:0006637]; animal organ regeneration [GO:0031100]; bile acid biosynthetic process [GO:0006699]; bile acid conjugation [GO:0002152]; bile acid metabolic process [GO:0008206]; fatty acid metabolic process [GO:0006631]; glycine metabolic process [GO:0006544]; liver development [GO:0001889]; taurine metabolic process [GO:0019530]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	acyl-CoA hydrolase activity [GO:0047617]; acyltransferase activity [GO:0016746]; carboxylic ester hydrolase activity [GO:0052689]; choloyl-CoA hydrolase activity [GO:0033882]; glycine N-choloyltransferase activity [GO:0047963]; long-chain acyl-CoA hydrolase activity [GO:0052816]; medium-chain acyl-CoA hydrolase activity [GO:0052815]; myristoyl-CoA hydrolase activity [GO:0102991]; N-acyltransferase activity [GO:0016410]; palmitoyl-CoA hydrolase activity [GO:0016290]; very long chain acyl-CoA hydrolase activity [GO:0052817]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; acyl-CoA hydrolase activity [GO:0047617]; acyltransferase activity [GO:0016746]; carboxylic ester hydrolase activity [GO:0052689]; choloyl-CoA hydrolase activity [GO:0033882]; glycine N-choloyltransferase activity [GO:0047963]; long-chain acyl-CoA hydrolase activity [GO:0052816]; medium-chain acyl-CoA hydrolase activity [GO:0052815]; myristoyl-CoA hydrolase activity [GO:0102991]; N-acyltransferase activity [GO:0016410]; palmitoyl-CoA hydrolase activity [GO:0016290]; very long chain acyl-CoA hydrolase activity [GO:0052817]; acyl-CoA metabolic process [GO:0006637]; animal organ regeneration [GO:0031100]; bile acid biosynthetic process [GO:0006699]; bile acid conjugation [GO:0002152]; bile acid metabolic process [GO:0008206]; fatty acid metabolic process [GO:0006631]; glycine metabolic process [GO:0006544]; liver development [GO:0001889]; taurine metabolic process [GO:0019530]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12810727, ECO:0000269|PubMed:23415802, ECO:0000269|PubMed:8034703}. Peroxisome {ECO:0000250|UniProtKB:Q63276}.
Q14050	reviewed	CO9A3_HUMAN	Collagen alpha-3(IX) chain	COL9A3	Homo sapiens (Human)	684	FUNCTION: Structural component of hyaline cartilage and vitreous of the eye.		extracellular matrix organization [GO:0030198]	collagen type IX trimer [GO:0005594]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein homodimerization activity [GO:0042803]	collagen type IX trimer [GO:0005594]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein homodimerization activity [GO:0042803]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q14055	reviewed	CO9A2_HUMAN	Collagen alpha-2(IX) chain	COL9A2	Homo sapiens (Human)	689	FUNCTION: Structural component of hyaline cartilage and vitreous of the eye.		extracellular matrix organization [GO:0030198]; skeletal system development [GO:0001501]	collagen type IX trimer [GO:0005594]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein homodimerization activity [GO:0042803]	collagen type IX trimer [GO:0005594]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein homodimerization activity [GO:0042803]; extracellular matrix organization [GO:0030198]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q14061	reviewed	COX17_HUMAN	Cytochrome c oxidase copper chaperone	COX17	Homo sapiens (Human)	63	FUNCTION: Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). {ECO:0000269|PubMed:19393246}.		copper ion transport [GO:0006825]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytochrome-c oxidase activity [GO:1904960]	cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]	copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]; cuprous ion binding [GO:1903136]; enzyme activator activity [GO:0008047]; ion binding [GO:0043167]	cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]; copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]; cuprous ion binding [GO:1903136]; enzyme activator activity [GO:0008047]; ion binding [GO:0043167]; copper ion transport [GO:0006825]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytochrome-c oxidase activity [GO:1904960]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:19393246}. Cytoplasm {ECO:0000269|PubMed:19393246}.
Q14088	reviewed	RB33A_HUMAN	Ras-related protein Rab-33A (Small GTP-binding protein S10)	RAB33A RABS10	Homo sapiens (Human)	237			antigen processing and presentation [GO:0019882]; Rab protein signal transduction [GO:0032482]	endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; antigen processing and presentation [GO:0019882]; Rab protein signal transduction [GO:0032482]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q14103	reviewed	HNRPD_HUMAN	Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)	HNRNPD AUF1 HNRPD	Homo sapiens (Human)	355	FUNCTION: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. {ECO:0000269|PubMed:10080887, ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:24423872}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to amino acid stimulus [GO:0071230]; cellular response to estradiol stimulus [GO:0071392]; cellular response to nitric oxide [GO:0071732]; cellular response to putrescine [GO:1904586]; cerebellum development [GO:0021549]; circadian regulation of translation [GO:0097167]; CRD-mediated mRNA stabilization [GO:0070934]; hepatocyte dedifferentiation [GO:1990828]; liver development [GO:0001889]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomerase RNA reverse transcriptase activity [GO:1905663]; positive regulation of telomere capping [GO:1904355]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of telomere maintenance [GO:0032204]; response to calcium ion [GO:0051592]; response to electrical stimulus [GO:0051602]; response to rapamycin [GO:1901355]; response to sodium phosphate [GO:1904383]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mCRD-mediated mRNA stability complex [GO:0106002]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]	chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mCRD-mediated mRNA stability complex [GO:0106002]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to amino acid stimulus [GO:0071230]; cellular response to estradiol stimulus [GO:0071392]; cellular response to nitric oxide [GO:0071732]; cellular response to putrescine [GO:1904586]; cerebellum development [GO:0021549]; circadian regulation of translation [GO:0097167]; CRD-mediated mRNA stabilization [GO:0070934]; hepatocyte dedifferentiation [GO:1990828]; liver development [GO:0001889]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomerase RNA reverse transcriptase activity [GO:1905663]; positive regulation of telomere capping [GO:1904355]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of telomere maintenance [GO:0032204]; response to calcium ion [GO:0051592]; response to electrical stimulus [GO:0051602]; response to rapamycin [GO:1901355]; response to sodium phosphate [GO:1904383]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.
Q14106	reviewed	TOB2_HUMAN	Protein Tob2 (Protein Tob4) (Transducer of erbB-2 2)	TOB2 KIAA1663 TOB4 TROB2	Homo sapiens (Human)	344	FUNCTION: Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.		female gamete generation [GO:0007292]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of osteoclast differentiation [GO:0045671]; osteoclast differentiation [GO:0030316]; positive regulation of ossification [GO:0045778]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	nuclear vitamin D receptor binding [GO:0042809]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; nuclear vitamin D receptor binding [GO:0042809]; transcription corepressor activity [GO:0003714]; female gamete generation [GO:0007292]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of osteoclast differentiation [GO:0045671]; osteoclast differentiation [GO:0030316]; positive regulation of ossification [GO:0045778]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Cytoplasm.
Q14108	reviewed	SCRB2_HUMAN	Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36)	SCARB2 CD36L2 LIMP2 LIMPII	Homo sapiens (Human)	478	FUNCTION: Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting. {ECO:0000269|PubMed:18022370}.; FUNCTION: (Microbial infection) Acts as a receptor for enterovirus 71. {ECO:0000269|PubMed:19543282, ECO:0000269|PubMed:30531980}.		aminophospholipid transport [GO:0015917]; gene expression [GO:0010467]; positive regulation of neuron projection development [GO:0010976]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; regulation of carbohydrate catabolic process [GO:0043470]; regulation of endosome organization [GO:1904978]; regulation of lysosome organization [GO:1905671]; sensory perception of sound [GO:0007605]	clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cargo receptor activity [GO:0038024]; cholesterol binding [GO:0015485]; enzyme binding [GO:0019899]; phosphatidylcholine binding [GO:0031210]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; scavenger receptor activity [GO:0005044]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]	clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cargo receptor activity [GO:0038024]; cholesterol binding [GO:0015485]; enzyme binding [GO:0019899]; phosphatidylcholine binding [GO:0031210]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; scavenger receptor activity [GO:0005044]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]; aminophospholipid transport [GO:0015917]; gene expression [GO:0010467]; positive regulation of neuron projection development [GO:0010976]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; regulation of carbohydrate catabolic process [GO:0043470]; regulation of endosome organization [GO:1904978]; regulation of lysosome organization [GO:1905671]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:18022370, ECO:0000269|PubMed:7509809}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:18022370, ECO:0000269|PubMed:7509809}.
Q14112	reviewed	NID2_HUMAN	Nidogen-2 (NID-2) (Osteonidogen)	NID2	Homo sapiens (Human)	1375	FUNCTION: Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.		basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
Q14114	reviewed	LRP8_HUMAN	Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)	LRP8 APOER2	Homo sapiens (Human)	963	FUNCTION: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands (PubMed:20223215). LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity). {ECO:0000250|UniProtKB:Q924X6, ECO:0000269|PubMed:12807892, ECO:0000269|PubMed:12899622, ECO:0000269|PubMed:12950167, ECO:0000269|PubMed:20223215, ECO:0000269|PubMed:30873003}.; FUNCTION: (Microbial infection) Acts as a receptor for Semliki Forest virus. {ECO:0000269|PubMed:34929721}.	MISCELLANEOUS: Natural isoforms of apoE (E2, E3, E4) have similar affinities for LRP8.; MISCELLANEOUS: [Isoform 5]: Contains an insert in the extracellular part which carries a furin cleavage site. {ECO:0000305}.	ammon gyrus development [GO:0021541]; cellular response to cholesterol [GO:0071397]; cellular response to growth factor stimulus [GO:0071363]; chemical synaptic transmission [GO:0007268]; cytokine-mediated signaling pathway [GO:0019221]; dendrite morphogenesis [GO:0048813]; endocytosis [GO:0006897]; layer formation in cerebral cortex [GO:0021819]; lipid metabolic process [GO:0006629]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of dendrite development [GO:1900006]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein tyrosine kinase activity [GO:0061098]; proteolysis [GO:0006508]; reelin-mediated signaling pathway [GO:0038026]; regulation of apoptotic process [GO:0042981]; regulation of innate immune response [GO:0045088]; response to xenobiotic stimulus [GO:0009410]; retinoid metabolic process [GO:0001523]; signal transduction [GO:0007165]; ventral spinal cord development [GO:0021517]	axon [GO:0030424]; caveola [GO:0005901]; cell surface [GO:0009986]; dendrite [GO:0030425]; extracellular space [GO:0005615]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; synapse [GO:0045202]	amyloid-beta binding [GO:0001540]; apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; cargo receptor activity [GO:0038024]; high-density lipoprotein particle binding [GO:0008035]; kinesin binding [GO:0019894]; low-density lipoprotein particle receptor activity [GO:0005041]; reelin receptor activity [GO:0038025]; transmembrane signaling receptor activity [GO:0004888]; very-low-density lipoprotein particle receptor activity [GO:0030229]	axon [GO:0030424]; caveola [GO:0005901]; cell surface [GO:0009986]; dendrite [GO:0030425]; extracellular space [GO:0005615]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; synapse [GO:0045202]; amyloid-beta binding [GO:0001540]; apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; cargo receptor activity [GO:0038024]; high-density lipoprotein particle binding [GO:0008035]; kinesin binding [GO:0019894]; low-density lipoprotein particle receptor activity [GO:0005041]; reelin receptor activity [GO:0038025]; transmembrane signaling receptor activity [GO:0004888]; very-low-density lipoprotein particle receptor activity [GO:0030229]; ammon gyrus development [GO:0021541]; cellular response to cholesterol [GO:0071397]; cellular response to growth factor stimulus [GO:0071363]; chemical synaptic transmission [GO:0007268]; cytokine-mediated signaling pathway [GO:0019221]; dendrite morphogenesis [GO:0048813]; endocytosis [GO:0006897]; layer formation in cerebral cortex [GO:0021819]; lipid metabolic process [GO:0006629]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of dendrite development [GO:1900006]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein tyrosine kinase activity [GO:0061098]; proteolysis [GO:0006508]; reelin-mediated signaling pathway [GO:0038026]; regulation of apoptotic process [GO:0042981]; regulation of innate immune response [GO:0045088]; response to xenobiotic stimulus [GO:0009410]; retinoid metabolic process [GO:0001523]; signal transduction [GO:0007165]; ventral spinal cord development [GO:0021517]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30873003}; Single-pass type I membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment. {ECO:0000250}.
Q14116	reviewed	IL18_HUMAN	Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)	IL18 IGIF IL1F4	Homo sapiens (Human)	193	FUNCTION: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:33883744}.	MISCELLANEOUS: [Isoform 2]: Expressed in ovarian carcinoma but undetectable in normal ovarian epithelial cells. Resistant to proteolytic activation by caspase-1 and -4. {ECO:0000305}.	activation of protein kinase B activity [GO:0032148]; angiogenesis [GO:0001525]; cell population proliferation [GO:0008283]; cell-cell signaling [GO:0007267]; cholesterol homeostasis [GO:0042632]; defense response to Gram-positive bacterium [GO:0050830]; establishment of skin barrier [GO:0061436]; inflammatory response [GO:0006954]; interleukin-18-mediated signaling pathway [GO:0035655]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of myoblast differentiation [GO:0045662]; neutrophil activation [GO:0042119]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of chemokine production [GO:0032722]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of cell adhesion [GO:0030155]; sleep [GO:0030431]; T-helper 1 type immune response [GO:0042088]; triglyceride homeostasis [GO:0070328]; type 2 immune response [GO:0042092]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; interleukin-18 receptor binding [GO:0045515]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; interleukin-18 receptor binding [GO:0045515]; activation of protein kinase B activity [GO:0032148]; angiogenesis [GO:0001525]; cell population proliferation [GO:0008283]; cell-cell signaling [GO:0007267]; cholesterol homeostasis [GO:0042632]; defense response to Gram-positive bacterium [GO:0050830]; establishment of skin barrier [GO:0061436]; inflammatory response [GO:0006954]; interleukin-18-mediated signaling pathway [GO:0035655]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of myoblast differentiation [GO:0045662]; neutrophil activation [GO:0042119]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of chemokine production [GO:0032722]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of cell adhesion [GO:0030155]; sleep [GO:0030431]; T-helper 1 type immune response [GO:0042088]; triglyceride homeostasis [GO:0070328]; type 2 immune response [GO:0042092]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33883744}. Note=The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33883744}.
Q14117	reviewed	DPYS_HUMAN	Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase)	DPYS	Homo sapiens (Human)	519	FUNCTION: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.		CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dUMP catabolic process [GO:0046079]; pyrimidine nucleobase catabolic process [GO:0006208]; thymine catabolic process [GO:0006210]; UMP catabolic process [GO:0046050]; uracil catabolic process [GO:0006212]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	dihydropyrimidinase activity [GO:0004157]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; dihydropyrimidinase activity [GO:0004157]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; zinc ion binding [GO:0008270]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dUMP catabolic process [GO:0046079]; pyrimidine nucleobase catabolic process [GO:0006208]; thymine catabolic process [GO:0006210]; UMP catabolic process [GO:0046050]; uracil catabolic process [GO:0006212]	
Q14118	reviewed	DAG1_HUMAN	Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]	DAG1	Homo sapiens (Human)	895	FUNCTION: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; FUNCTION: [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). {ECO:0000250|UniProtKB:O18738}.; FUNCTION: [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; FUNCTION: [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:19324387, PubMed:17360738). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927). {ECO:0000269|PubMed:16254364, ECO:0000269|PubMed:17360738, ECO:0000269|PubMed:19324387, ECO:0000269|PubMed:9851927}.		angiogenesis involved in wound healing [GO:0060055]; axon guidance [GO:0007411]; axon regeneration [GO:0031103]; basement membrane organization [GO:0071711]; branching involved in salivary gland morphogenesis [GO:0060445]; calcium-dependent cell-matrix adhesion [GO:0016340]; cellular response to cholesterol [GO:0071397]; cellular response to mechanical stimulus [GO:0071260]; commissural neuron axon guidance [GO:0071679]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; heart morphogenesis [GO:0003007]; membrane protein ectodomain proteolysis [GO:0006509]; microtubule anchoring [GO:0034453]; morphogenesis of an epithelial sheet [GO:0002011]; morphogenesis of an epithelium [GO:0002009]; muscle attachment [GO:0016203]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cell migration [GO:0030336]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; nerve development [GO:0021675]; nerve maturation [GO:0021682]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; protein transport [GO:0015031]; regulation of embryonic cell shape [GO:0016476]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of synapse organization [GO:0050807]; regulation of synaptic plasticity [GO:0048167]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to muscle activity [GO:0014850]; response to peptide hormone [GO:0043434]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; skeletal muscle tissue regeneration [GO:0043403]	adherens junction [GO:0005912]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; collagen-containing extracellular matrix [GO:0062023]; contractile ring [GO:0070938]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dystroglycan complex [GO:0016011]; dystrophin-associated glycoprotein complex [GO:0016010]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic cytosol [GO:0099524]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]	actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; calcium ion binding [GO:0005509]; dystroglycan binding [GO:0002162]; laminin binding [GO:0043236]; laminin-1 binding [GO:0043237]; protein-containing complex binding [GO:0044877]; SH2 domain binding [GO:0042169]; structural constituent of muscle [GO:0008307]; tubulin binding [GO:0015631]; vinculin binding [GO:0017166]; virus receptor activity [GO:0001618]	adherens junction [GO:0005912]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; collagen-containing extracellular matrix [GO:0062023]; contractile ring [GO:0070938]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dystroglycan complex [GO:0016011]; dystrophin-associated glycoprotein complex [GO:0016010]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic cytosol [GO:0099524]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; calcium ion binding [GO:0005509]; dystroglycan binding [GO:0002162]; laminin binding [GO:0043236]; laminin-1 binding [GO:0043237]; protein-containing complex binding [GO:0044877]; SH2 domain binding [GO:0042169]; structural constituent of muscle [GO:0008307]; tubulin binding [GO:0015631]; vinculin binding [GO:0017166]; virus receptor activity [GO:0001618]; angiogenesis involved in wound healing [GO:0060055]; axon guidance [GO:0007411]; axon regeneration [GO:0031103]; basement membrane organization [GO:0071711]; branching involved in salivary gland morphogenesis [GO:0060445]; calcium-dependent cell-matrix adhesion [GO:0016340]; cellular response to cholesterol [GO:0071397]; cellular response to mechanical stimulus [GO:0071260]; commissural neuron axon guidance [GO:0071679]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; heart morphogenesis [GO:0003007]; membrane protein ectodomain proteolysis [GO:0006509]; microtubule anchoring [GO:0034453]; morphogenesis of an epithelial sheet [GO:0002011]; morphogenesis of an epithelium [GO:0002009]; muscle attachment [GO:0016203]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cell migration [GO:0030336]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; nerve development [GO:0021675]; nerve maturation [GO:0021682]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; protein transport [GO:0015031]; regulation of embryonic cell shape [GO:0016476]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of synapse organization [GO:0050807]; regulation of synaptic plasticity [GO:0048167]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to muscle activity [GO:0014850]; response to peptide hormone [GO:0043434]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; skeletal muscle tissue regeneration [GO:0043403]	SUBCELLULAR LOCATION: [Alpha-dystroglycan]: Secreted, extracellular space.; SUBCELLULAR LOCATION: [Beta-dystroglycan]: Cell membrane {ECO:0000269|PubMed:18764929}; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm {ECO:0000269|PubMed:18764929}. Cell membrane, sarcolemma {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}. Note=The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 (By similarity). In peripheral nerves, localizes to the Schwann cell membrane. Colocalizes with ERM proteins in Schwann-cell microvilli. {ECO:0000250}.
Q14119	reviewed	VEZF1_HUMAN	Vascular endothelial zinc finger 1 (Putative transcription factor DB1) (Zinc finger protein 161)	VEZF1 DB1 ZNF161	Homo sapiens (Human)	521	FUNCTION: Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3. {ECO:0000269|PubMed:36657711, ECO:0000269|PubMed:8035792}.		angiogenesis [GO:0001525]; cellular defense response [GO:0006968]; endothelial cell development [GO:0001885]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; angiogenesis [GO:0001525]; cellular defense response [GO:0006968]; endothelial cell development [GO:0001885]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8035792}.
Q14123	reviewed	PDE1C_HUMAN	Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3)	PDE1C	Homo sapiens (Human)	709	FUNCTION: Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8557689, PubMed:29860631). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). {ECO:0000269|PubMed:29860631, ECO:0000269|PubMed:8557689, ECO:0000305|PubMed:29860631}.		signal transduction [GO:0007165]	cytosol [GO:0005829]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin binding [GO:0005516]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin binding [GO:0005516]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q64338}.
Q14126	reviewed	DSG2_HUMAN	Desmoglein-2 (Cadherin family member 5) (HDGC)	DSG2 CDHF5	Homo sapiens (Human)	1118	FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.		bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maternal process involved in female pregnancy [GO:0060135]; Purkinje myocyte development [GO:0003165]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; response to progesterone [GO:0032570]	apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]	apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maternal process involved in female pregnancy [GO:0060135]; Purkinje myocyte development [GO:0003165]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; response to progesterone [GO:0032570]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31402609}; Single-pass type I membrane protein. Cell junction, desmosome {ECO:0000269|PubMed:31402609}.
Q14129	reviewed	DGCR6_HUMAN	Protein DGCR6 (DiGeorge syndrome critical region 6)	DGCR6	Homo sapiens (Human)	220	FUNCTION: May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.		animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]	extracellular matrix [GO:0031012]; nucleus [GO:0005634]		extracellular matrix [GO:0031012]; nucleus [GO:0005634]; animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15821931}. Note=Predominantly nuclear.
Q14134	reviewed	TRI29_HUMAN	Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein)	TRIM29 ATDC	Homo sapiens (Human)	588	FUNCTION: Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}.		innate immune response [GO:0045087]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122]	adherens junction [GO:0005912]; lysosome [GO:0005764]	cadherin binding involved in cell-cell adhesion [GO:0098641]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; zinc ion binding [GO:0008270]	adherens junction [GO:0005912]; lysosome [GO:0005764]; cadherin binding involved in cell-cell adhesion [GO:0098641]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7644499}. Lysosome {ECO:0000269|PubMed:27695001}. Note=Colocalizes with intermediate filaments.
Q14135	reviewed	VGLL4_HUMAN	Transcription cofactor vestigial-like protein 4 (Vgl-4)	VGLL4 KIAA0121	Homo sapiens (Human)	290	FUNCTION: May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}.	MISCELLANEOUS: [Isoform 3]: Probable target of nonsense-mediated mRNA decay. {ECO:0000305}.	negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0035331]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein catabolic process [GO:0045732]	nucleus [GO:0005634]	transcription coactivator binding [GO:0001223]	nucleus [GO:0005634]; transcription coactivator binding [GO:0001223]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0035331]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein catabolic process [GO:0045732]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q14137	reviewed	BOP1_HUMAN	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein)	BOP1 KIAA0124	Homo sapiens (Human)	746	FUNCTION: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:17353269, ECO:0000269|PubMed:24120868}.		cell population proliferation [GO:0008283]; cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000448]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosome biogenesis [GO:0042254]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]; ribonucleoprotein complex [GO:1990904]	ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; cell population proliferation [GO:0008283]; cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000448]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:12429849}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:12429849}.
Q14139	reviewed	UBE4A_HUMAN	Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A)	UBE4A KIAA0126	Homo sapiens (Human)	1066	FUNCTION: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. {ECO:0000250|UniProtKB:E9Q735, ECO:0000250|UniProtKB:P54860}.		protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	ubiquitin-ubiquitin ligase activity [GO:0034450]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; ubiquitin-ubiquitin ligase activity [GO:0034450]; protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:E9Q735}.
Q14140	reviewed	SRTD2_HUMAN	SERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2)	SERTAD2 KIAA0127 TRIPBR2	Homo sapiens (Human)	314	FUNCTION: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. {ECO:0000269|PubMed:11331592}.		negative regulation of cell growth [GO:0030308]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; negative regulation of cell growth [GO:0030308]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18316374}. Cytoplasm {ECO:0000269|PubMed:18316374}. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.
Q14141	reviewed	SEPT6_HUMAN	Septin-6	SEPTIN6 KIAA0128 SEP2 SEPT6	Homo sapiens (Human)	434	FUNCTION: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}.	MISCELLANEOUS: Coordinated expression with SEPTIN2 and SEPTIN7.	cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; mitotic cytokinesis [GO:0000281]; spermatogenesis [GO:0007283]	axon terminus [GO:0043679]; cell division site [GO:0032153]; cleavage furrow [GO:0032154]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; septin collar [GO:0032173]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]	axon terminus [GO:0043679]; cell division site [GO:0032153]; cleavage furrow [GO:0032154]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; septin collar [GO:0032173]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]; cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; mitotic cytokinesis [GO:0000281]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15774761}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15774761}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15774761}. Cleavage furrow {ECO:0000269|PubMed:15774761}. Midbody {ECO:0000269|PubMed:15774761}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:25588830}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Found in the sperm annulus (PubMed:25588830). {ECO:0000269|PubMed:25588830}.
Q14142	reviewed	TRI14_HUMAN	Tripartite motif-containing protein 14	TRIM14 KIAA0129	Homo sapiens (Human)	442	FUNCTION: Plays an essential role in the innate immune defense against viruses and bacteria (PubMed:30150992, PubMed:32404352). Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373). Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593). Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression (PubMed:32404352). Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q8BVW3, ECO:0000269|PubMed:24379373, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:29053956, ECO:0000269|PubMed:30150992, ECO:0000269|PubMed:32404352}.		innate immune response [GO:0045087]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; phagocytic vesicle [GO:0045335]	transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; phagocytic vesicle [GO:0045335]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:24379373, ECO:0000269|PubMed:28476934, ECO:0000269|PubMed:29053956}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:32404352}.
Q14145	reviewed	KEAP1_HUMAN	Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19)	KEAP1 INRF2 KIAA0132 KLHL19	Homo sapiens (Human)	624	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15983046, PubMed:15601839). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:19489739, PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835). {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16006525, ECO:0000269|PubMed:17046835, ECO:0000269|PubMed:17127771, ECO:0000269|PubMed:18251510, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:29590092}.		cellular response to interleukin-4 [GO:0071353]; cellular response to oxidative stress [GO:0034599]; in utero embryonic development [GO:0001701]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; regulation of autophagy [GO:0010506]; regulation of epidermal cell differentiation [GO:0045604]; ubiquitin-dependent protein catabolic process [GO:0006511]	actin filament [GO:0005884]; centriolar satellite [GO:0034451]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; inclusion body [GO:0016234]; midbody [GO:0030496]; nucleoplasm [GO:0005654]	disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	actin filament [GO:0005884]; centriolar satellite [GO:0034451]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; inclusion body [GO:0016234]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; cellular response to interleukin-4 [GO:0071353]; cellular response to oxidative stress [GO:0034599]; in utero embryonic development [GO:0001701]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; regulation of autophagy [GO:0010506]; regulation of epidermal cell differentiation [GO:0045604]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:15657435, ECO:0000269|PubMed:19424503}. Nucleus {ECO:0000269|PubMed:15657435}. Note=Mainly cytoplasmic (PubMed:15601839). In response to selective autophagy, relocalizes to inclusion bodies following interaction with SQSTM1/p62 (PubMed:20452972). {ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:20452972}.
Q14147	reviewed	DHX34_HUMAN	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) (DExH-box helicase 34)	DHX34 DDX34 KIAA0134	Homo sapiens (Human)	1143	FUNCTION: Probable ATP-binding RNA helicase required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons (PubMed:25220460, PubMed:33205750). Promotes the phosphorylation of UPF1 along with its interaction with key NMD pathway proteins UPF2 and EIF4A3 (PubMed:25220460). Interaction with the RUVBL1-RUVBL2 complex results in loss of nucleotide binding ability and ATP hydrolysis of the complex (PubMed:33205750). Negatively regulates the nucleotide binding ability and ATP hydrolysis of the RUVBL1-RUVBL2 complex via induction of N-terminus conformation changes of the RUVBL2 subunits (PubMed:33205750). {ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:33205750}.		negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of phosphorylation [GO:0042327]	membrane [GO:0016020]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	membrane [GO:0016020]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of phosphorylation [GO:0042327]	
Q14149	reviewed	MORC3_HUMAN	MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3)	MORC3 KIAA0136 NXP2 ZCWCC3	Homo sapiens (Human)	939	FUNCTION: Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}.		antiviral innate immune response [GO:0140374]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cellular senescence [GO:2000774]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]	chromatin [GO:0000785]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; methylated histone binding [GO:0035064]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; methylated histone binding [GO:0035064]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; antiviral innate immune response [GO:0140374]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cellular senescence [GO:2000774]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504}. Nucleus matrix {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:20501696}. Nucleus, PML body {ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:27440897}. Chromosome {ECO:0000250|UniProtKB:F7BJB9}. Note=Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent. {ECO:0000269|PubMed:20501696}.
Q14151	reviewed	SAFB2_HUMAN	Scaffold attachment factor B2 (SAF-B2)	SAFB2 KIAA0138	Homo sapiens (Human)	953	FUNCTION: Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.		regulation of androgen receptor signaling pathway [GO:0060765]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; Sertoli cell differentiation [GO:0060008]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; Sertoli cell differentiation [GO:0060008]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q14152	reviewed	EIF3A_HUMAN	Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185)	EIF3A EIF3S10 KIAA0139	Homo sapiens (Human)	1382	FUNCTION: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.		formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; translation reinitiation [GO:0002188]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; microtubule [GO:0005874]; multi-eIF complex [GO:0043614]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]	mRNA binding [GO:0003729]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; microtubule [GO:0005874]; multi-eIF complex [GO:0043614]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; mRNA binding [GO:0003729]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; translation initiation factor activity [GO:0003743]; formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; translation reinitiation [GO:0002188]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:9150439}.
Q14153	reviewed	FA53B_HUMAN	Protein FAM53B (Protein simplet)	FAM53B KIAA0140 SMP	Homo sapiens (Human)	422	FUNCTION: Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}.		positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein import into nucleus [GO:0006606]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055]	nucleus [GO:0005634]		nucleus [GO:0005634]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein import into nucleus [GO:0006606]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25183871}.
Q14154	reviewed	DELE1_HUMAN	DAP3-binding cell death enhancer 1 (DAP3-binding cell death enhancer 1, long form) (DELE1(L)) (Death ligand signal enhancer) [Cleaved into: DAP3-binding cell death enhancer 1 short form (DELE1(S)) (S-DELE1)]	DELE1 DELE KIAA0141	Homo sapiens (Human)	515	FUNCTION: Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency and mitochondrial stress (PubMed:32132706, PubMed:32132707, PubMed:35388015, PubMed:37327776). Detects impaired protein import and processing in mitochondria, activating the ISR (PubMed:35388015). May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667). {ECO:0000269|PubMed:20563667, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:35388015, ECO:0000269|PubMed:37327776}.; FUNCTION: [DAP3-binding cell death enhancer 1]: Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR. {ECO:0000269|PubMed:37327776}.; FUNCTION: [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (PubMed:32132706, PubMed:32132707, PubMed:37327776). It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (PubMed:32132706, PubMed:32132707). {ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:37327776}.		extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]	SUBCELLULAR LOCATION: [DAP3-binding cell death enhancer 1]: Mitochondrion {ECO:0000269|PubMed:20563667, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:37327776}. Mitochondrion outer membrane {ECO:0000269|PubMed:37327776}. Mitochondrion inner membrane {ECO:0000269|PubMed:32132707}. Note=Imported in the mitochondrial matrix in absence of stress, leading to its degradation by LONP1 (PubMed:37327776). Localizes at the mitochondrial surface in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting localization at the mitochondrial surface and stabilization (PubMed:37327776). Associates with the mitochondrion inner membrane in response to mitochondrial stress, leading to its proteolytic processing by OMA1, and generation of the AP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1) (PubMed:32132707). {ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:37327776}.; SUBCELLULAR LOCATION: [DAP3-binding cell death enhancer 1 short form]: Cytoplasm, cytosol {ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707}. Note=This short form is generated by proteolytic processing by OMA1 in response to mitochondrial stress, leading to translocation to the cytosol. {ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707}.
Q14155	reviewed	ARHG7_HUMAN	Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)	ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314	Homo sapiens (Human)	803	FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.		ephrin receptor signaling pathway [GO:0048013]; focal adhesion assembly [GO:0048041]; Golgi organization [GO:0007030]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; negative regulation of microtubule nucleation [GO:1905833]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of GTPase activity [GO:0043547]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of GTP binding [GO:1904424]; signal transduction [GO:0007165]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mitotic spindle pole [GO:0097431]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]	gamma-tubulin binding [GO:0043015]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mitotic spindle pole [GO:0097431]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; gamma-tubulin binding [GO:0043015]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]; ephrin receptor signaling pathway [GO:0048013]; focal adhesion assembly [GO:0048041]; Golgi organization [GO:0007030]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; negative regulation of microtubule nucleation [GO:1905833]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of GTPase activity [GO:0043547]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of GTP binding [GO:1904424]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.
Q14156	reviewed	EFR3A_HUMAN	Protein EFR3 homolog A (Protein EFR3-like)	EFR3A KIAA0143	Homo sapiens (Human)	821	FUNCTION: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000305}.		phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	cytosol [GO:0005829]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; plasma membrane [GO:0005886]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825}; Lipid-anchor {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825}. Cytoplasm, cytosol {ECO:0000269|PubMed:25380825}. Note=Palmitoylation anchors the protein to the plasma membrane (PubMed:23229899, PubMed:25380825, PubMed:26571211). A small amount is observed in the cytosol (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:26571211}.
Q14157	reviewed	UBP2L_HUMAN	Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L)	UBAP2L KIAA0144 NICE4	Homo sapiens (Human)	1087	FUNCTION: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.		binding of sperm to zona pellucida [GO:0007339]; hematopoietic stem cell homeostasis [GO:0061484]; positive regulation of stress granule assembly [GO:0062029]; stress granule assembly [GO:0034063]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]	RNA binding [GO:0003723]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; RNA binding [GO:0003723]; binding of sperm to zona pellucida [GO:0007339]; hematopoietic stem cell homeostasis [GO:0061484]; positive regulation of stress granule assembly [GO:0062029]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35633597}. Chromosome {ECO:0000269|PubMed:35633597}. Cytoplasm {ECO:0000269|PubMed:35633597}. Cytoplasm, Stress granule {ECO:0000305|PubMed:29395067}. Note=Associates with nuclear chromatin. {ECO:0000269|PubMed:35633597}.
Q14159	reviewed	SPIDR_HUMAN	DNA repair-scaffolding protein (Scaffolding protein involved in DNA repair)	SPIDR KIAA0146	Homo sapiens (Human)	915	FUNCTION: Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. {ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:27967308, ECO:0000269|PubMed:34697795}.		cellular response to camptothecin [GO:0072757]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of establishment of protein localization to chromosome [GO:0070202]	nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]		nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; cellular response to camptothecin [GO:0072757]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of establishment of protein localization to chromosome [GO:0070202]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23509288}. Note=Together with BLM, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment.
Q14160	reviewed	SCRIB_HUMAN	Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	Homo sapiens (Human)	1630	FUNCTION: Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:19041750, PubMed:18716323, PubMed:18641685, PubMed:16965391, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed:18716323, PubMed:18641685). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity. {ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.		activation of GTPase activity [GO:0090630]; apoptotic process involved in morphogenesis [GO:0060561]; astrocyte cell migration [GO:0043615]; auditory receptor cell stereocilium organization [GO:0060088]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell adhesion [GO:0098609]; cochlear nucleus development [GO:0021747]; establishment of apical/basal cell polarity [GO:0035089]; establishment of T cell polarity [GO:0001768]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; mammary gland duct morphogenesis [GO:0060603]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of mitotic cell cycle [GO:0045930]; neural tube closure [GO:0001843]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; polarized epithelial cell differentiation [GO:0030859]; positive chemotaxis [GO:0050918]; positive regulation of apoptotic process [GO:0043065]; positive regulation of receptor recycling [GO:0001921]; positive regulation of type II interferon production [GO:0032729]; post-anal tail morphogenesis [GO:0036342]; protein localization to adherens junction [GO:0071896]; receptor clustering [GO:0043113]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle targeting [GO:0016080]; wound healing [GO:0042060]	adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; lamellipodium [GO:0030027]; myelin sheath abaxonal region [GO:0035748]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; Scrib-APC-beta-catenin complex [GO:0034750]	cadherin binding [GO:0045296]; signaling adaptor activity [GO:0035591]	adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; lamellipodium [GO:0030027]; myelin sheath abaxonal region [GO:0035748]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; Scrib-APC-beta-catenin complex [GO:0034750]; cadherin binding [GO:0045296]; signaling adaptor activity [GO:0035591]; activation of GTPase activity [GO:0090630]; apoptotic process involved in morphogenesis [GO:0060561]; astrocyte cell migration [GO:0043615]; auditory receptor cell stereocilium organization [GO:0060088]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell adhesion [GO:0098609]; cochlear nucleus development [GO:0021747]; establishment of apical/basal cell polarity [GO:0035089]; establishment of T cell polarity [GO:0001768]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; mammary gland duct morphogenesis [GO:0060603]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of mitotic cell cycle [GO:0045930]; neural tube closure [GO:0001843]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; polarized epithelial cell differentiation [GO:0030859]; positive chemotaxis [GO:0050918]; positive regulation of apoptotic process [GO:0043065]; positive regulation of receptor recycling [GO:0001921]; positive regulation of type II interferon production [GO:0032729]; post-anal tail morphogenesis [GO:0036342]; protein localization to adherens junction [GO:0071896]; receptor clustering [GO:0043113]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle targeting [GO:0016080]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28169360}; Peripheral membrane protein. Cell junction {ECO:0000269|PubMed:27380321}. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Postsynapse {ECO:0000269|PubMed:15182672}. Presynapse {ECO:0000269|PubMed:15182672}. Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (By similarity). {ECO:0000250|UniProtKB:Q80U72}.
Q14161	reviewed	GIT2_HUMAN	ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)	GIT2 KIAA0148	Homo sapiens (Human)	759	FUNCTION: GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}.		brain development [GO:0007420]; regulation of ARF protein signal transduction [GO:0032012]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; synaptic vesicle recycling [GO:0036465]	focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; presynapse [GO:0098793]; synapse [GO:0045202]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]	focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; presynapse [GO:0098793]; synapse [GO:0045202]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; brain development [GO:0007420]; regulation of ARF protein signal transduction [GO:0032012]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; synaptic vesicle recycling [GO:0036465]	
Q14162	reviewed	SREC_HUMAN	Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I)	SCARF1 KIAA0149 SREC	Homo sapiens (Human)	830	FUNCTION: Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898]	endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; plasma membrane [GO:0005886]	low-density lipoprotein particle binding [GO:0030169]; scavenger receptor activity [GO:0005044]; transmembrane signaling receptor activity [GO:0004888]	endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; plasma membrane [GO:0005886]; low-density lipoprotein particle binding [GO:0030169]; scavenger receptor activity [GO:0005044]; transmembrane signaling receptor activity [GO:0004888]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q14164	reviewed	IKKE_HUMAN	Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)	IKBKE IKKE IKKI KIAA0151	Homo sapiens (Human)	716	FUNCTION: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}.		cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; gene expression [GO:0010467]; immune response [GO:0006955]; interleukin-17-mediated signaling pathway [GO:0097400]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mRNA stabilization [GO:0048255]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of lipid storage [GO:0010884]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein phosphorylation [GO:0006468]; regulation of protein-containing complex assembly [GO:0043254]; response to interferon-beta [GO:0035456]; type I interferon-mediated signaling pathway [GO:0060337]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; serine/threonine protein kinase complex [GO:1902554]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; IkappaB kinase activity [GO:0008384]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; NF-kappaB-inducing kinase activity [GO:0004704]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; serine/threonine protein kinase complex [GO:1902554]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; IkappaB kinase activity [GO:0008384]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; NF-kappaB-inducing kinase activity [GO:0004704]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase binding [GO:0031625]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; gene expression [GO:0010467]; immune response [GO:0006955]; interleukin-17-mediated signaling pathway [GO:0097400]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mRNA stabilization [GO:0048255]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of lipid storage [GO:0010884]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein phosphorylation [GO:0006468]; regulation of protein-containing complex assembly [GO:0043254]; response to interferon-beta [GO:0035456]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24882218}. Nucleus. Nucleus, PML body {ECO:0000269|PubMed:20188669}. Note=Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent (PubMed:20188669). Located diffusely throughout the cytoplasm but locates to punctate cytoplasmic bodies when coexpressed with TRIM6 (PubMed:24882218). {ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:24882218}.
Q14165	reviewed	MLEC_HUMAN	Malectin	MLEC KIAA0152	Homo sapiens (Human)	292	FUNCTION: Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity). {ECO:0000250}.		carbohydrate metabolic process [GO:0005975]; protein N-linked glycosylation [GO:0006487]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	carbohydrate binding [GO:0030246]; enzyme binding [GO:0019899]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; carbohydrate binding [GO:0030246]; enzyme binding [GO:0019899]; carbohydrate metabolic process [GO:0005975]; protein N-linked glycosylation [GO:0006487]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q14166	reviewed	TTL12_HUMAN	Tubulin--tyrosine ligase-like protein 12 (Inactive tubulin--tyrosine ligase-like protein 12)	TTLL12 KIAA0153	Homo sapiens (Human)	644	FUNCTION: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935). {ECO:0000269|PubMed:20162578, ECO:0000269|PubMed:23251473, ECO:0000269|PubMed:28011935}.		innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein modification process [GO:0036211]; regulation of mitotic cell cycle [GO:0007346]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]	ATP binding [GO:0005524]; H4K20me3 modified histone binding [GO:1990889]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; ATP binding [GO:0005524]; H4K20me3 modified histone binding [GO:1990889]; tubulin binding [GO:0015631]; innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein modification process [GO:0036211]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20162578, ECO:0000269|PubMed:28011935}. Midbody {ECO:0000305|PubMed:20162578}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000305|PubMed:20162578}. Cytoplasm, cytoskeleton, spindle {ECO:0000305|PubMed:20162578}. Nucleus {ECO:0000269|PubMed:23251473}. Note=Predominantly localizes in the cytoplasm (PubMed:28011935). Partially colocalizes with vimentin in prostate cancer cells (PubMed:20162578). {ECO:0000269|PubMed:20162578, ECO:0000269|PubMed:28011935}.
Q14168	reviewed	MPP2_HUMAN	MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2)	MPP2 DLG2	Homo sapiens (Human)	576	FUNCTION: Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017). {ECO:0000250|UniProtKB:D3ZAA9, ECO:0000250|UniProtKB:Q9WV34, ECO:0000269|PubMed:19665017}.		excitatory postsynaptic potential [GO:0060079]; long-term synaptic potentiation [GO:0060291]; protein homooligomerization [GO:0051260]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite membrane [GO:0032590]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]		cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite membrane [GO:0032590]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; excitatory postsynaptic potential [GO:0060079]; long-term synaptic potentiation [GO:0060291]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19665017}. Membrane {ECO:0000269|PubMed:19665017}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9WV34}. Postsynaptic density {ECO:0000250|UniProtKB:Q9WV34}. Note=Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts. {ECO:0000250|UniProtKB:Q9WV34}.
Q14181	reviewed	DPOA2_HUMAN	DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit)	POLA2	Homo sapiens (Human)	598	FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000269|PubMed:9705292}.		DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of RNA primer [GO:0006269]; protein import into nucleus [GO:0006606]	alpha DNA polymerase:primase complex [GO:0005658]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]	alpha DNA polymerase:primase complex [GO:0005658]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of RNA primer [GO:0006269]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Nucleus.
Q14183	reviewed	DOC2A_HUMAN	Double C2-like domain-containing protein alpha (Doc2) (Doc2-alpha)	DOC2A	Homo sapiens (Human)	400	FUNCTION: Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:18354201, ECO:0000269|PubMed:9736751, ECO:0000269|PubMed:9804756}.		calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; nervous system development [GO:0007399]; regulation of calcium ion-dependent exocytosis [GO:0017158]; spontaneous neurotransmitter secretion [GO:0061669]	cell junction [GO:0030054]; extrinsic component of synaptic vesicle membrane [GO:0098850]; glutamatergic synapse [GO:0098978]; lysosome [GO:0005764]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; synapse [GO:0045202]	calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]	cell junction [GO:0030054]; extrinsic component of synaptic vesicle membrane [GO:0098850]; glutamatergic synapse [GO:0098978]; lysosome [GO:0005764]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; synapse [GO:0045202]; calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; nervous system development [GO:0007399]; regulation of calcium ion-dependent exocytosis [GO:0017158]; spontaneous neurotransmitter secretion [GO:0061669]	SUBCELLULAR LOCATION: Lysosome {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Synapse, synaptosome.
Q14184	reviewed	DOC2B_HUMAN	Double C2-like domain-containing protein beta (Doc2-beta)	DOC2B DOC2BL	Homo sapiens (Human)	412	FUNCTION: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:9804756}.		calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; exocytosis [GO:0006887]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of insulin secretion [GO:0032024]; positive regulation of vesicle fusion [GO:0031340]; protein localization [GO:0008104]; regulation of calcium ion-dependent exocytosis [GO:0017158]; spontaneous neurotransmitter secretion [GO:0061669]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synapse [GO:0045202]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; syntaxin binding [GO:0019905]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; syntaxin binding [GO:0019905]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; exocytosis [GO:0006887]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of insulin secretion [GO:0032024]; positive regulation of vesicle fusion [GO:0031340]; protein localization [GO:0008104]; regulation of calcium ion-dependent exocytosis [GO:0017158]; spontaneous neurotransmitter secretion [GO:0061669]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic granule {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the plasma membrane in a calcium-dependent manner. {ECO:0000250}.
Q14185	reviewed	DOCK1_HUMAN	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)	DOCK1	Homo sapiens (Human)	1865	FUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). {ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:8657152}.		apoptotic process [GO:0006915]; cell migration [GO:0016477]; integrin-mediated signaling pathway [GO:0007229]; myoblast fusion [GO:0007520]; phagocytosis, engulfment [GO:0006911]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; guanyl-nucleotide exchange factor complex [GO:0032045]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; guanyl-nucleotide exchange factor complex [GO:0032045]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]; apoptotic process [GO:0006915]; cell migration [GO:0016477]; integrin-mediated signaling pathway [GO:0007229]; myoblast fusion [GO:0007520]; phagocytosis, engulfment [GO:0006911]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}. Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000305}.
Q14186	reviewed	TFDP1_HUMAN	Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1)	TFDP1 DP1	Homo sapiens (Human)	410	FUNCTION: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537, ECO:0000269|PubMed:8405995}.	MISCELLANEOUS: E2F/DP transactivation can be mediated by several cofactors including TBP, TFIIH, MDM2 and CBP.	anoikis [GO:0043276]; epidermis development [GO:0008544]; negative regulation of fat cell proliferation [GO:0070345]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA biosynthetic process [GO:2000278]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rb-E2F complex [GO:0035189]; RNA polymerase II transcription regulator complex [GO:0090575]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein domain specific binding [GO:0019904]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rb-E2F complex [GO:0035189]; RNA polymerase II transcription regulator complex [GO:0090575]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein domain specific binding [GO:0019904]; anoikis [GO:0043276]; epidermis development [GO:0008544]; negative regulation of fat cell proliferation [GO:0070345]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA biosynthetic process [GO:2000278]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q08639}. Cytoplasm {ECO:0000250|UniProtKB:Q08639}. Note=Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1. {ECO:0000250|UniProtKB:Q08639}.
Q14188	reviewed	TFDP2_HUMAN	Transcription factor Dp-2 (E2F dimerization partner 2)	TFDP2 DP2	Homo sapiens (Human)	446	FUNCTION: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000305|PubMed:20176812}.		cell cycle [GO:0007049]; heart development [GO:0007507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; transcription factor binding [GO:0008134]	chromatin [GO:0000785]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; transcription factor binding [GO:0008134]; cell cycle [GO:0007049]; heart development [GO:0007507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q14190	reviewed	SIM2_HUMAN	Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15)	SIM2 BHLHE15	Homo sapiens (Human)	667	FUNCTION: Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.		cell differentiation [GO:0030154]; embryonic pattern specification [GO:0009880]; lung development [GO:0030324]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cell differentiation [GO:0030154]; embryonic pattern specification [GO:0009880]; lung development [GO:0030324]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00632, ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:14697214}.
Q14191	reviewed	WRN_HUMAN	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 3.6.4.12)]	WRN RECQ3 RECQL2	Homo sapiens (Human)	1432	FUNCTION: Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation. {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109}.		base-excision repair [GO:0006284]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; cellular senescence [GO:0090398]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; G-quadruplex DNA unwinding [GO:0044806]; positive regulation of hydrolase activity [GO:0051345]; positive regulation of strand invasion [GO:0098530]; protein localization to nucleolus [GO:1902570]; regulation of growth rate [GO:0040009]; replication fork processing [GO:0031297]; replicative senescence [GO:0090399]; response to oxidative stress [GO:0006979]; response to UV-C [GO:0010225]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820]	centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; 3'-flap-structured DNA binding [GO:0070337]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bubble DNA binding [GO:0000405]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; exonuclease activity [GO:0004527]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MutLalpha complex binding [GO:0032405]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]	centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; 3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; 3'-flap-structured DNA binding [GO:0070337]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bubble DNA binding [GO:0000405]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; exonuclease activity [GO:0004527]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MutLalpha complex binding [GO:0032405]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]; base-excision repair [GO:0006284]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; cellular senescence [GO:0090398]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; G-quadruplex DNA unwinding [GO:0044806]; positive regulation of hydrolase activity [GO:0051345]; positive regulation of strand invasion [GO:0098530]; protein localization to nucleolus [GO:1902570]; regulation of growth rate [GO:0040009]; replication fork processing [GO:0031297]; replicative senescence [GO:0090399]; response to oxidative stress [GO:0006979]; response to UV-C [GO:0010225]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:23180761, ECO:0000269|PubMed:9618508}. Nucleus {ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:23180761}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21639834}. Chromosome {ECO:0000269|PubMed:27063109}. Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation (PubMed:21639834). Localizes to DNA damage sites (PubMed:27063109). {ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109}.
Q14192	reviewed	FHL2_HUMAN	Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)	FHL2 DRAL SLIM3	Homo sapiens (Human)	279	FUNCTION: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}.		atrial cardiac muscle cell development [GO:0055014]; heart trabecula formation [GO:0060347]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; response to hormone [GO:0009725]; ventricular cardiac muscle cell development [GO:0055015]	focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Z disc [GO:0030018]	bHLH transcription factor binding [GO:0043425]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]	focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Z disc [GO:0030018]; bHLH transcription factor binding [GO:0043425]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; atrial cardiac muscle cell development [GO:0055014]; heart trabecula formation [GO:0060347]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; response to hormone [GO:0009725]; ventricular cardiac muscle cell development [GO:0055015]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11813260, ECO:0000269|PubMed:16652157}. Nucleus {ECO:0000269|PubMed:11813260, ECO:0000269|PubMed:16652157}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:O35115}.
Q14194	reviewed	DPYL1_HUMAN	Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3)	CRMP1 DPYSL1 ULIP3	Homo sapiens (Human)	572	FUNCTION: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). {ECO:0000269|PubMed:11562390, ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:25358863}.		negative regulation of actin filament binding [GO:1904530]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]	centrosome [GO:0005813]; cytosol [GO:0005829]; growth cone [GO:0030426]; midbody [GO:0030496]; perikaryon [GO:0043204]; spindle [GO:0005819]	filamin binding [GO:0031005]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; identical protein binding [GO:0042802]	centrosome [GO:0005813]; cytosol [GO:0005829]; growth cone [GO:0030426]; midbody [GO:0030496]; perikaryon [GO:0043204]; spindle [GO:0005819]; filamin binding [GO:0031005]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; identical protein binding [GO:0042802]; negative regulation of actin filament binding [GO:1904530]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11562390}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11562390}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11562390}. Cell projection, growth cone {ECO:0000250|UniProtKB:P97427}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P97427}. Perikaryon {ECO:0000250|UniProtKB:P97427}. Note=Associated with centrosomes and the mitotic spindle during metaphase (PubMed:11562390). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity). {ECO:0000250|UniProtKB:P97427, ECO:0000269|PubMed:11562390}.
Q14195	reviewed	DPYL3_HUMAN	Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1)	DPYSL3 CRMP4 DRP3 ULIP ULIP1	Homo sapiens (Human)	570	FUNCTION: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}.		actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; cellular response to cytokine stimulus [GO:0071345]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron projection development [GO:0010977]; neuron development [GO:0048666]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of neuron projection development [GO:0010976]; response to axon injury [GO:0048678]	cell body [GO:0044297]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; extracellular space [GO:0005615]; filamentous actin [GO:0031941]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; synapse [GO:0045202]	chondroitin sulfate binding [GO:0035374]; filamin binding [GO:0031005]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]	cell body [GO:0044297]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; extracellular space [GO:0005615]; filamentous actin [GO:0031941]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; synapse [GO:0045202]; chondroitin sulfate binding [GO:0035374]; filamin binding [GO:0031005]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; cellular response to cytokine stimulus [GO:0071345]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron projection development [GO:0010977]; neuron development [GO:0048666]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of neuron projection development [GO:0010976]; response to axon injury [GO:0048678]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. {ECO:0000250}.
Q14197	reviewed	ICT1_HUMAN	Large ribosomal subunit protein mL62 (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Digestion substraction 1) (DS-1) (Immature colon carcinoma transcript 1 protein) (Peptidyl-tRNA hydrolase ICT1, mitochondrial) (EC 3.1.1.29)	MRPL58 DS1 ICT1	Homo sapiens (Human)	206	FUNCTION: Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit (PubMed:20186120, PubMed:33878294). Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation (PubMed:33878294). Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (PubMed:20186120, PubMed:33878294). {ECO:0000269|PubMed:20186120, ECO:0000269|PubMed:33878294}.		mitochondrial translation [GO:0032543]; mitochondrial translational termination [GO:0070126]; rescue of stalled ribosome [GO:0072344]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	aminoacyl-tRNA hydrolase activity [GO:0004045]; translation release factor activity, codon nonspecific [GO:0016150]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; aminoacyl-tRNA hydrolase activity [GO:0004045]; translation release factor activity, codon nonspecific [GO:0016150]; mitochondrial translation [GO:0032543]; mitochondrial translational termination [GO:0070126]; rescue of stalled ribosome [GO:0072344]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20186120, ECO:0000269|PubMed:23908630, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q14202	reviewed	ZMYM3_HUMAN	Zinc finger MYM-type protein 3 (Zinc finger protein 261)	ZMYM3 DXS6673E KIAA0385 ZNF261	Homo sapiens (Human)	1370	FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.		cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]	nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q14203	reviewed	DCTN1_HUMAN	Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)	DCTN1	Homo sapiens (Human)	1278	FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}.		cell division [GO:0051301]; centriole-centriole cohesion [GO:0010457]; establishment of mitotic spindle orientation [GO:0000132]; maintenance of synapse structure [GO:0099558]; melanosome transport [GO:0032402]; microtubule anchoring at centrosome [GO:0034454]; mitotic cell cycle [GO:0000278]; motor behavior [GO:0061744]; nervous system development [GO:0007399]; neuromuscular junction development [GO:0007528]; neuromuscular process [GO:0050905]; neuron cellular homeostasis [GO:0070050]; neuron projection maintenance [GO:1990535]; non-motile cilium assembly [GO:1905515]; nuclear membrane disassembly [GO:0051081]; nuclear migration [GO:0007097]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuromuscular junction development [GO:1904398]; regulation of mitotic spindle organization [GO:0060236]; retrograde transport, endosome to Golgi [GO:0042147]; ventral spinal cord development [GO:0021517]	axon [GO:0030424]; cell cortex [GO:0005938]; cell cortex region [GO:0099738]; cell leading edge [GO:0031252]; centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein complex [GO:0030286]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; spindle [GO:0005819]; spindle pole [GO:0000922]	microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; tau protein binding [GO:0048156]; tubulin binding [GO:0015631]	axon [GO:0030424]; cell cortex [GO:0005938]; cell cortex region [GO:0099738]; cell leading edge [GO:0031252]; centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein complex [GO:0030286]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; spindle [GO:0005819]; spindle pole [GO:0000922]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; tau protein binding [GO:0048156]; tubulin binding [GO:0015631]; cell division [GO:0051301]; centriole-centriole cohesion [GO:0010457]; establishment of mitotic spindle orientation [GO:0000132]; maintenance of synapse structure [GO:0099558]; melanosome transport [GO:0032402]; microtubule anchoring at centrosome [GO:0034454]; mitotic cell cycle [GO:0000278]; motor behavior [GO:0061744]; nervous system development [GO:0007399]; neuromuscular junction development [GO:0007528]; neuromuscular process [GO:0050905]; neuron cellular homeostasis [GO:0070050]; neuron projection maintenance [GO:1990535]; non-motile cilium assembly [GO:1905515]; nuclear membrane disassembly [GO:0051081]; nuclear migration [GO:0007097]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuromuscular junction development [GO:1904398]; regulation of mitotic spindle organization [GO:0060236]; retrograde transport, endosome to Golgi [GO:0042147]; ventral spinal cord development [GO:0021517]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17828277}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17828277, ECO:0000269|PubMed:22777741, ECO:0000269|PubMed:25774020, ECO:0000269|PubMed:26972003}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20719959, ECO:0000269|PubMed:23985322, ECO:0000269|PubMed:25774020}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:25774020}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25774020}. Nucleus envelope {ECO:0000269|PubMed:20679239}. Cytoplasm, cell cortex {ECO:0000269|PubMed:22327364}. Note=Localizes to microtubule plus ends (PubMed:17828277, PubMed:22777741, PubMed:25774020). Localizes preferentially to the ends of tyrosinated microtubules (PubMed:26972003). Localization at centrosome is regulated by SLK-dependent phosphorylation (PubMed:23985322). Localizes to centrosome in a PARKDA-dependent manner (PubMed:20719959). Localizes to the subdistal appendage region of the centriole in a KIF3A-dependent manner (PubMed:23386061). PLK1-mediated phosphorylation at Ser-179 is essential for its localization in the nuclear envelope (PubMed:20679239). {ECO:0000269|PubMed:17828277, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:20719959, ECO:0000269|PubMed:22777741, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23985322, ECO:0000269|PubMed:25774020, ECO:0000269|PubMed:26972003}.
Q14204	reviewed	DYHC1_HUMAN	Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	Homo sapiens (Human)	4646	FUNCTION: Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}.		cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; establishment of spindle localization [GO:0051293]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097]; P-body assembly [GO:0033962]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of intracellular transport [GO:0032388]; positive regulation of spindle assembly [GO:1905832]; regulation of metaphase plate congression [GO:0090235]; regulation of mitotic spindle organization [GO:0060236]; retrograde axonal transport [GO:0008090]; stress granule assembly [GO:0034063]	axon cytoplasm [GO:1904115]; azurophil granule lumen [GO:0035578]; cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; dynein complex [GO:0030286]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium [GO:0030175]; membrane [GO:0016020]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; RNA binding [GO:0003723]	axon cytoplasm [GO:1904115]; azurophil granule lumen [GO:0035578]; cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; dynein complex [GO:0030286]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium [GO:0030175]; membrane [GO:0016020]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; RNA binding [GO:0003723]; cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; establishment of spindle localization [GO:0051293]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097]; P-body assembly [GO:0033962]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of intracellular transport [GO:0032388]; positive regulation of spindle assembly [GO:1905832]; regulation of metaphase plate congression [GO:0090235]; regulation of mitotic spindle organization [GO:0060236]; retrograde axonal transport [GO:0008090]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305|PubMed:36071160}.
Q14207	reviewed	NPAT_HUMAN	Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220)	NPAT CAND3 E14	Homo sapiens (Human)	1427	FUNCTION: Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}.		in utero embryonic development [GO:0001701]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; Gemini of coiled bodies [GO:0097504]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; Gemini of coiled bodies [GO:0097504]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; in utero embryonic development [GO:0001701]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	SUBCELLULAR LOCATION: Nucleus. Nucleus, Cajal body. Note=Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases.
Q14209	reviewed	E2F2_HUMAN	Transcription factor E2F2 (E2F-2)	E2F2	Homo sapiens (Human)	437	FUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.		intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; lens fiber cell apoptotic process [GO:1990086]; negative regulation of sprouting angiogenesis [GO:1903671]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; transcription initiation at RNA polymerase II promoter [GO:0006367]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; Rb-E2F complex [GO:0035189]; RNA polymerase II transcription regulator complex [GO:0090575]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; Rb-E2F complex [GO:0035189]; RNA polymerase II transcription regulator complex [GO:0090575]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; lens fiber cell apoptotic process [GO:1990086]; negative regulation of sprouting angiogenesis [GO:1903671]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus.
Q14210	reviewed	LY6D_HUMAN	Lymphocyte antigen 6D (Ly-6D) (E48 antigen)	LY6D E48	Homo sapiens (Human)	128	FUNCTION: May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification.		cell adhesion [GO:0007155]; lymphocyte differentiation [GO:0030098]; response to stilbenoid [GO:0035634]	cell surface [GO:0009986]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		cell surface [GO:0009986]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell adhesion [GO:0007155]; lymphocyte differentiation [GO:0030098]; response to stilbenoid [GO:0035634]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
Q14213	reviewed	IL27B_HUMAN	Interleukin-27 subunit beta (IL-27 subunit beta) (IL-27B) (Epstein-Barr virus-induced gene 3 protein) (EBV-induced gene 3 protein)	EBI3 IL27B	Homo sapiens (Human)	229	FUNCTION: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. {ECO:0000269|PubMed:12121660}.		cytokine-mediated signaling pathway [GO:0019221]; humoral immune response [GO:0006959]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of type II interferon production [GO:0032729]; T cell proliferation [GO:0042098]; T-helper 1 type immune response [GO:0042088]	endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine activity [GO:0005125]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-27 receptor binding [GO:0045523]	endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine activity [GO:0005125]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-27 receptor binding [GO:0045523]; cytokine-mediated signaling pathway [GO:0019221]; humoral immune response [GO:0006959]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of type II interferon production [GO:0032729]; T cell proliferation [GO:0042098]; T-helper 1 type immune response [GO:0042088]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9342359}.
Q14232	reviewed	EI2BA_HUMAN	Translation initiation factor eIF-2B subunit alpha (eIF-2B GDP-GTP exchange factor subunit alpha)	EIF2B1 EIF2BA	Homo sapiens (Human)	305	FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.		oligodendrocyte development [GO:0014003]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; membrane [GO:0016020]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; membrane [GO:0016020]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; translation initiation factor activity [GO:0003743]; oligodendrocyte development [GO:0014003]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	
Q14240	reviewed	IF4A2_HUMAN	Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)	EIF4A2 DDX2B EIF4F	Homo sapiens (Human)	407	FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.		cellular response to leukemia inhibitory factor [GO:1990830]; cytoplasmic translational initiation [GO:0002183]; negative regulation of RNA-dependent RNA polymerase activity [GO:1900260]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; translation initiation factor activity [GO:0003743]; cellular response to leukemia inhibitory factor [GO:1990830]; cytoplasmic translational initiation [GO:0002183]; negative regulation of RNA-dependent RNA polymerase activity [GO:1900260]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	
Q14241	reviewed	ELOA1_HUMAN	Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3)	ELOA TCEB3 MSTP059	Homo sapiens (Human)	798	FUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). {ECO:0000269|PubMed:8654961}.; FUNCTION: As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A. {ECO:0000269|PubMed:19920177}.		regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]	elongin complex [GO:0070449]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; site of DNA damage [GO:0090734]		elongin complex [GO:0070449]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; site of DNA damage [GO:0090734]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35633597}. Note=Localizes to sites of DNA damage. {ECO:0000269|PubMed:35633597}.
Q14242	reviewed	SELPL_HUMAN	P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162)	SELPLG	Homo sapiens (Human)	412	FUNCTION: A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. {ECO:0000269|PubMed:11566773, ECO:0000269|PubMed:12403782}.; FUNCTION: (Microbial infection) Acts as a receptor for enterovirus 71. {ECO:0000269|PubMed:19543284}.		cell adhesion [GO:0007155]; cellular response to interleukin-6 [GO:0071354]; leukocyte adhesive activation [GO:0050902]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]	membrane [GO:0016020]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; uropod [GO:0001931]	signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618]	membrane [GO:0016020]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; uropod [GO:0001931]; signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618]; cell adhesion [GO:0007155]; cellular response to interleukin-6 [GO:0071354]; leukocyte adhesive activation [GO:0050902]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q14244	reviewed	MAP7_HUMAN	Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7)	MAP7	Homo sapiens (Human)	749	FUNCTION: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}.		establishment or maintenance of cell polarity [GO:0007163]; microtubule cytoskeleton organization [GO:0000226]; protein localization to plasma membrane [GO:0072659]; response to osmotic stress [GO:0006970]	axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; perinuclear region of cytoplasm [GO:0048471]	signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]	axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; perinuclear region of cytoplasm [GO:0048471]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; establishment or maintenance of cell polarity [GO:0007163]; microtubule cytoskeleton organization [GO:0000226]; protein localization to plasma membrane [GO:0072659]; response to osmotic stress [GO:0006970]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts.
Q14246	reviewed	AGRE1_HUMAN	Adhesion G protein-coupled receptor E1 (EGF-like module receptor 1) (EGF-like module-containing mucin-like hormone receptor-like 1) (EMR1 hormone receptor)	ADGRE1 EMR1 TM7LN3	Homo sapiens (Human)	886	FUNCTION: Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development. {ECO:0000250|UniProtKB:Q61549}.	MISCELLANEOUS: Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain. {ECO:0000305}.	adaptive immune response [GO:0002250]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; adaptive immune response [GO:0002250]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24530099}; Multi-pass membrane protein {ECO:0000255}.
Q14247	reviewed	SRC8_HUMAN	Src substrate cortactin (Amplaxin) (Oncogene EMS1)	CTTN EMS1	Homo sapiens (Human)	550	FUNCTION: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}.		actin cytoskeleton organization [GO:0030036]; cell motility [GO:0048870]; dendritic spine maintenance [GO:0097062]; extrinsic apoptotic signaling pathway [GO:0097191]; focal adhesion assembly [GO:0048041]; intracellular protein transport [GO:0006886]; lamellipodium organization [GO:0097581]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of smooth muscle contraction [GO:0045987]; receptor-mediated endocytosis [GO:0006898]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of axon extension [GO:0030516]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]	cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; mitotic spindle midzone [GO:1990023]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; voltage-gated potassium channel complex [GO:0008076]	cadherin binding [GO:0045296]; profilin binding [GO:0005522]	cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; mitotic spindle midzone [GO:1990023]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; voltage-gated potassium channel complex [GO:0008076]; cadherin binding [GO:0045296]; profilin binding [GO:0005522]; actin cytoskeleton organization [GO:0030036]; cell motility [GO:0048870]; dendritic spine maintenance [GO:0097062]; extrinsic apoptotic signaling pathway [GO:0097191]; focal adhesion assembly [GO:0048041]; intracellular protein transport [GO:0006886]; lamellipodium organization [GO:0097581]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of smooth muscle contraction [GO:0045987]; receptor-mediated endocytosis [GO:0006898]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of axon extension [GO:0030516]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12151401}. Cell projection, lamellipodium {ECO:0000269|PubMed:12151401, ECO:0000269|PubMed:24574519}. Cell projection, ruffle. Cell projection, dendrite {ECO:0000250}. Cell projection {ECO:0000250|UniProtKB:Q66HL2}. Cell membrane {ECO:0000305|PubMed:17959782}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, podosome {ECO:0000250|UniProtKB:Q01406}. Cell junction {ECO:0000250|UniProtKB:Q66HL2}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q66HL2}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q66HL2}. Cell projection, dendritic spine {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12151401}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q01406}. Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2}.
Q14249	reviewed	NUCG_HUMAN	Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-)	ENDOG	Homo sapiens (Human)	297	FUNCTION: Endonuclease that preferentially catalyzes the cleavage of double-stranded 5-hydroxymethylcytosine (5hmC)-modified DNA (PubMed:25355512). The 5hmC-modified nucleotide does not increase the binding affinity, but instead increases the efficiency of cutting and specifies the site of cleavage for the modified DNAs (By similarity). Shows significantly higher affinity for four-stranded Holliday junction over duplex and single-stranded DNAs (By similarity). Promotes conservative recombination when the DNA is 5hmC-modified (PubMed:25355512). Promotes autophagy through the suppression of mTOR by its phosphorylation-mediated interaction with YWHAG and its endonuclease activity-mediated DNA damage response (PubMed:33473107). GSK3-beta mediated phosphorylation of ENDOG enhances its interaction with YWHAG, leading to the release of TSC2 and PIK3C3 from YWHAG resulting in mTOR pathway suppression and autophagy initiation (PubMed:33473107). Promotes cleavage of mtDNA in response to oxidative and nitrosative stress, in turn inducing compensatory mtDNA replication (PubMed:29719607). {ECO:0000250|UniProtKB:O08600, ECO:0000269|PubMed:25355512, ECO:0000269|PubMed:29719607, ECO:0000269|PubMed:33473107}.		apoptotic DNA fragmentation [GO:0006309]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; in utero embryonic development [GO:0001701]; mitochondrial DNA catabolic process [GO:0032043]; negative regulation of TOR signaling [GO:0032007]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of mitochondrial DNA replication [GO:0090297]; response to antibiotic [GO:0046677]; response to tumor necrosis factor [GO:0034612]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	DNA endonuclease activity [GO:0004520]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; RNA endonuclease activity [GO:0004521]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; DNA endonuclease activity [GO:0004520]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; RNA endonuclease activity [GO:0004521]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; apoptotic DNA fragmentation [GO:0006309]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; in utero embryonic development [GO:0001701]; mitochondrial DNA catabolic process [GO:0032043]; negative regulation of TOR signaling [GO:0032007]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of mitochondrial DNA replication [GO:0090297]; response to antibiotic [GO:0046677]; response to tumor necrosis factor [GO:0034612]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:33473107}.
Q14254	reviewed	FLOT2_HUMAN	Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1)	FLOT2 ESA1 M17S1	Homo sapiens (Human)	428	FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.		anterograde dendritic transport [GO:0098937]; cell adhesion [GO:0007155]; epidermis development [GO:0008544]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of gene expression [GO:0010629]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein localization to plasma membrane [GO:0072659]; protein localization to plasma membrane raft [GO:0044860]; protein stabilization [GO:0050821]; regulation of myoblast differentiation [GO:0045661]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]	acrosomal membrane [GO:0002080]; adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell contact zone [GO:0044291]; cytoplasmic vesicle [GO:0031410]; dendrite cytoplasm [GO:0032839]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931]; vesicle [GO:0031982]		acrosomal membrane [GO:0002080]; adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell contact zone [GO:0044291]; cytoplasmic vesicle [GO:0031410]; dendrite cytoplasm [GO:0032839]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931]; vesicle [GO:0031982]; anterograde dendritic transport [GO:0098937]; cell adhesion [GO:0007155]; epidermis development [GO:0008544]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of gene expression [GO:0010629]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein localization to plasma membrane [GO:0072659]; protein localization to plasma membrane raft [GO:0044860]; protein stabilization [GO:0050821]; regulation of myoblast differentiation [GO:0045661]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20682791}; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Membrane, caveola {ECO:0000269|PubMed:20682791}; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Endosome {ECO:0000269|PubMed:20682791}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Membrane-associated protein of caveolae.
Q14257	reviewed	RCN2_HUMAN	Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP)	RCN2 ERC55	Homo sapiens (Human)	317	FUNCTION: Not known. Binds calcium.			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; nucleolus [GO:0005730]	calcium ion binding [GO:0005509]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; nucleolus [GO:0005730]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
Q14258	reviewed	TRI25_HUMAN	E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)	TRIM25 EFP RNF147 ZNF147	Homo sapiens (Human)	630	FUNCTION: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:30193849, PubMed:33849980, PubMed:29357390, PubMed:31710640, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28202764, PubMed:28060952). Mediates also the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}.		antiviral innate immune response [GO:0140374]; cellular response to leukemia inhibitory factor [GO:1990830]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein monoubiquitination [GO:0006513]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to estrogen [GO:0043627]; response to oxidative stress [GO:0006979]; response to vitamin D [GO:0033280]; suppression of viral release by host [GO:0044790]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral release from host cell [GO:0019076]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	cadherin binding [GO:0045296]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]; RIG-I binding [GO:0039552]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; cadherin binding [GO:0045296]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]; RIG-I binding [GO:0039552]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; antiviral innate immune response [GO:0140374]; cellular response to leukemia inhibitory factor [GO:1990830]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein monoubiquitination [GO:0006513]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to estrogen [GO:0043627]; response to oxidative stress [GO:0006979]; response to vitamin D [GO:0033280]; suppression of viral release by host [GO:0044790]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17392790}. Cytoplasm, Stress granule {ECO:0000269|PubMed:23950712}. Nucleus {ECO:0000250|UniProtKB:Q61510}.
Q14264	reviewed	ENR1_HUMAN	Endogenous retrovirus group 3 member 1 Env polyprotein (ERV-3 envelope protein) (ERV3 envelope protein) (ERV3-1 envelope protein) (Envelope polyprotein) (HERV-R envelope protein) (ERV-R envelope protein) (HERV-R_7q21.2 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERV3-1 ERV3	Homo sapiens (Human)	604	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro. {ECO:0000269|PubMed:10692254, ECO:0000269|PubMed:14557543, ECO:0000269|PubMed:7645262}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: HERV-R_7q21.2 genomic and subgenomic RNAs have been observed.; MISCELLANEOUS: This provirus is intergenic, the closest flanking genes being ZNF117 and FLJ25037.					SUBCELLULAR LOCATION: Virion.
Q14289	reviewed	FAK2_HUMAN	Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)	PTK2B FAK2 PYK2 RAFTK	Homo sapiens (Human)	1009	FUNCTION: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}.	MISCELLANEOUS: Promotes bone resorption, and thus PTK2B/PYK2 inhibitors might be used to treat osteoporosis.	activation of Janus kinase activity [GO:0042976]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; blood vessel endothelial cell migration [GO:0043534]; bone resorption [GO:0045453]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; cellular response to fluid shear stress [GO:0071498]; cellular response to retinoic acid [GO:0071300]; chemokine-mediated signaling pathway [GO:0070098]; endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; focal adhesion assembly [GO:0048041]; glial cell proliferation [GO:0014009]; integrin-mediated signaling pathway [GO:0007229]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of potassium ion transport [GO:0043267]; neuron projection development [GO:0031175]; oocyte maturation [GO:0001556]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell chemotaxis [GO:2000538]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron projection development [GO:0010976]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of translation [GO:0045727]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein-containing complex assembly [GO:0065003]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell adhesion [GO:0030155]; regulation of cell shape [GO:0008360]; regulation of establishment of cell polarity [GO:2000114]; regulation of inositol trisphosphate biosynthetic process [GO:0032960]; regulation of macrophage chemotaxis [GO:0010758]; regulation of NMDA receptor activity [GO:2000310]; regulation of postsynaptic density assembly [GO:0099151]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of synaptic plasticity [GO:0048167]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to calcium ion [GO:0051592]; response to cAMP [GO:0051591]; response to cation stress [GO:0043157]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to hormone [GO:0009725]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to ischemia [GO:0002931]; response to mechanical stimulus [GO:0009612]; response to xenobiotic stimulus [GO:0009410]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; stress fiber assembly [GO:0043149]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	apical dendrite [GO:0097440]; cell body [GO:0044297]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; NMDA selective glutamate receptor complex [GO:0017146]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]	3-phosphoinositide-dependent protein kinase binding [GO:0043423]; ATP binding [GO:0005524]; calmodulin-dependent protein kinase activity [GO:0004683]; NMDA glutamate receptor activity [GO:0004972]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein self-association [GO:0043621]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]	apical dendrite [GO:0097440]; cell body [GO:0044297]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; NMDA selective glutamate receptor complex [GO:0017146]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; 3-phosphoinositide-dependent protein kinase binding [GO:0043423]; ATP binding [GO:0005524]; calmodulin-dependent protein kinase activity [GO:0004683]; NMDA glutamate receptor activity [GO:0004972]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein self-association [GO:0043621]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; activation of Janus kinase activity [GO:0042976]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; blood vessel endothelial cell migration [GO:0043534]; bone resorption [GO:0045453]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; cellular response to fluid shear stress [GO:0071498]; cellular response to retinoic acid [GO:0071300]; chemokine-mediated signaling pathway [GO:0070098]; endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; focal adhesion assembly [GO:0048041]; glial cell proliferation [GO:0014009]; integrin-mediated signaling pathway [GO:0007229]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of potassium ion transport [GO:0043267]; neuron projection development [GO:0031175]; oocyte maturation [GO:0001556]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell chemotaxis [GO:2000538]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron projection development [GO:0010976]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of translation [GO:0045727]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein-containing complex assembly [GO:0065003]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell adhesion [GO:0030155]; regulation of cell shape [GO:0008360]; regulation of establishment of cell polarity [GO:2000114]; regulation of inositol trisphosphate biosynthetic process [GO:0032960]; regulation of macrophage chemotaxis [GO:0010758]; regulation of NMDA receptor activity [GO:2000310]; regulation of postsynaptic density assembly [GO:0099151]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of synaptic plasticity [GO:0048167]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to calcium ion [GO:0051592]; response to cAMP [GO:0051591]; response to cation stress [GO:0043157]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to hormone [GO:0009725]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to ischemia [GO:0002931]; response to mechanical stimulus [GO:0009612]; response to xenobiotic stimulus [GO:0009410]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; stress fiber assembly [GO:0043149]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus. Note=Interaction with NPHP1 induces the membrane-association of the kinase. Colocalizes with integrins at the cell periphery.
Q14296	reviewed	FASTK_HUMAN	Fas-activated serine/threonine kinase (FAST kinase) (EC 2.7.11.1) (EC 2.7.11.8)	FASTK	Homo sapiens (Human)	549	FUNCTION: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. {ECO:0000269|PubMed:17135269, ECO:0000269|PubMed:7544399}.; FUNCTION: [Isoform 4]: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels. {ECO:0000269|PubMed:25704814}.		apoptotic signaling pathway [GO:0097190]; mitochondrial RNA processing [GO:0000963]; protein phosphorylation [GO:0006468]; regulation of mitochondrial mRNA stability [GO:0044528]; regulation of RNA splicing [GO:0043484]	mitochondrial matrix [GO:0005759]; ribonucleoprotein granule [GO:0035770]	ATP binding [GO:0005524]; Fas-activated serine/threonine kinase activity [GO:0033867]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]	mitochondrial matrix [GO:0005759]; ribonucleoprotein granule [GO:0035770]; ATP binding [GO:0005524]; Fas-activated serine/threonine kinase activity [GO:0033867]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; apoptotic signaling pathway [GO:0097190]; mitochondrial RNA processing [GO:0000963]; protein phosphorylation [GO:0006468]; regulation of mitochondrial mRNA stability [GO:0044528]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion matrix {ECO:0000269|PubMed:25704814}. Note=Colocalizes with mitochondrial RNA granules. {ECO:0000269|PubMed:25704814}.
Q14314	reviewed	FGL2_HUMAN	Fibroleukin (Fibrinogen-like protein 2) (pT49)	FGL2	Homo sapiens (Human)	439	FUNCTION: May play a role in physiologic lymphocyte functions at mucosal sites.		negative regulation of defense response to virus [GO:0050687]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of macrophage antigen processing and presentation [GO:0002617]; negative regulation of memory T cell differentiation [GO:0043381]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; ficolin-1-rich granule lumen [GO:1904813]		collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; ficolin-1-rich granule lumen [GO:1904813]; negative regulation of defense response to virus [GO:0050687]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of macrophage antigen processing and presentation [GO:0002617]; negative regulation of memory T cell differentiation [GO:0043381]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]	SUBCELLULAR LOCATION: Secreted.
Q14315	reviewed	FLNC_HUMAN	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	FLNC ABPL FLN2	Homo sapiens (Human)	2725	FUNCTION: Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.	MISCELLANEOUS: Silenced in MKN28 and MKN74 gastric cancer cell lines due to aberrant methylation of the gene.	sarcomere organization [GO:0045214]	costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intercellular bridge [GO:0045171]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]	costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intercellular bridge [GO:0045171]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; sarcomere organization [GO:0045214]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11038172, ECO:0000269|PubMed:25351925}. Membrane {ECO:0000269|PubMed:11038172}; Peripheral membrane protein {ECO:0000269|PubMed:11038172}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11038172}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11038172}. Note=A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme. Targeting to developing and mature Z lines is mediated by the intradomain insert.
Q14318	reviewed	FKBP8_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)	FKBP8 FKBP38	Homo sapiens (Human)	412	FUNCTION: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796, ECO:0000269|PubMed:28169297}.	MISCELLANEOUS: Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.; MISCELLANEOUS: [Isoform 3]: Interacts with BCL2L1/BCLX. {ECO:0000305}.	apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; camera-type eye development [GO:0043010]; dorsal/ventral neural tube patterning [GO:0021904]; intracellular signal transduction [GO:0035556]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; neuron fate specification [GO:0048665]; positive regulation of BMP signaling pathway [GO:0030513]; protein folding [GO:0006457]; protein localization to mitochondrion [GO:0070585]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of gene expression [GO:0010468]; smoothened signaling pathway [GO:0007224]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial envelope [GO:0005740]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	calmodulin binding [GO:0005516]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding chaperone [GO:0044183]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial envelope [GO:0005740]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; calmodulin binding [GO:0005516]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding chaperone [GO:0044183]; apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; camera-type eye development [GO:0043010]; dorsal/ventral neural tube patterning [GO:0021904]; intracellular signal transduction [GO:0035556]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; neuron fate specification [GO:0048665]; positive regulation of BMP signaling pathway [GO:0030513]; protein folding [GO:0006457]; protein localization to mitochondrion [GO:0070585]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of gene expression [GO:0010468]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16176796}. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion membrane {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:18385096}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion membrane {ECO:0000269|PubMed:18385096}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}.
Q14320	reviewed	FA50A_HUMAN	Protein FAM50A (Protein HXC-26) (Protein XAP-5)	FAM50A DXS9928E HXC26 XAP5	Homo sapiens (Human)	339	FUNCTION: Probably involved in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:32703943}.		chromatin organization [GO:0006325]; mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; chromatin organization [GO:0006325]; mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32703943}.
Q14330	reviewed	GPR18_HUMAN	N-arachidonyl glycine receptor (NAGly receptor) (G-protein coupled receptor 18)	GPR18 GPCRW	Homo sapiens (Human)	331	FUNCTION: Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937). {ECO:0000250|UniProtKB:Q8K1Z6, ECO:0000269|PubMed:16844083, ECO:0000269|PubMed:24762058, ECO:0000269|PubMed:27572937}.		CD8-positive, alpha-beta intraepithelial T cell differentiation [GO:0002300]; CD8-positive, gamma-delta intraepithelial T cell differentiation [GO:0002305]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of tumor necrosis factor production [GO:0032720]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	cytoplasmic vesicle membrane [GO:0030659]; membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	cytoplasmic vesicle membrane [GO:0030659]; membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; CD8-positive, alpha-beta intraepithelial T cell differentiation [GO:0002300]; CD8-positive, gamma-delta intraepithelial T cell differentiation [GO:0002305]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of tumor necrosis factor production [GO:0032720]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24762058, ECO:0000269|PubMed:27018161}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:24762058}.
Q14331	reviewed	FRG1_HUMAN	Protein FRG1 (FSHD region gene 1 protein)	FRG1	Homo sapiens (Human)	258	FUNCTION: Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15060122, ECO:0000269|PubMed:20970242, ECO:0000269|PubMed:21699900, ECO:0000269|PubMed:23720823}.		mRNA splicing, via spliceosome [GO:0000398]; muscle organ development [GO:0007517]; rRNA processing [GO:0006364]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; striated muscle dense body [GO:0055120]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; RNA binding [GO:0003723]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; striated muscle dense body [GO:0055120]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; muscle organ development [GO:0007517]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, Cajal body {ECO:0000269|PubMed:15060122, ECO:0000269|PubMed:17103222, ECO:0000269|PubMed:21699900}. Nucleus, nucleolus {ECO:0000269|PubMed:15060122, ECO:0000269|PubMed:20970242, ECO:0000269|PubMed:21699900}. Cytoplasm {ECO:0000269|PubMed:20970242, ECO:0000269|PubMed:21699900}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:20970242}. Note=Localization changes during myogenesis from mainly cytoplasmic in undifferentiated myoblasts, to strongly nucleolar in early myotubes and back to cytoplasmic 5 days post-differentiation (PubMed:20970242). Localized at the Z-line in the sarcomere of matured myotubes 8 days post-differentiation (PubMed:20970242). {ECO:0000269|PubMed:20970242}.
Q14332	reviewed	FZD2_HUMAN	Frizzled-2 (Fz-2) (hFz2) (FzE2)	FZD2	Homo sapiens (Human)	565	FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:25759469). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. {ECO:0000269|PubMed:25759469}.; FUNCTION: (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium (PubMed:27680706, PubMed:29748286). TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling (PubMed:29748286). {ECO:0000269|PubMed:27680706, ECO:0000269|PubMed:29748286}.		canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; endothelial cell differentiation [GO:0045446]; hard palate development [GO:0060022]; inner ear receptor cell development [GO:0060119]; membranous septum morphogenesis [GO:0003149]; muscular septum morphogenesis [GO:0003150]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; sensory perception of smell [GO:0007608]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; endothelial cell differentiation [GO:0045446]; hard palate development [GO:0060022]; inner ear receptor cell development [GO:0060119]; membranous septum morphogenesis [GO:0003149]; muscular septum morphogenesis [GO:0003150]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; sensory perception of smell [GO:0007608]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q14344	reviewed	GNA13_HUMAN	Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13)	GNA13	Homo sapiens (Human)	377	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). {ECO:0000250|UniProtKB:P27601, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:12515866, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:16705036, ECO:0000269|PubMed:16787920, ECO:0000269|PubMed:27084452}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; branching involved in blood vessel morphogenesis [GO:0001569]; cell differentiation [GO:0030154]; in utero embryonic development [GO:0001701]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; platelet activation [GO:0030168]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of blood pressure [GO:0008217]; regulation of cell shape [GO:0008360]; regulation of fibroblast migration [GO:0010762]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; heterotrimeric G-protein complex [GO:0005834]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	D5 dopamine receptor binding [GO:0031752]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; heterotrimeric G-protein complex [GO:0005834]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; D5 dopamine receptor binding [GO:0031752]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; branching involved in blood vessel morphogenesis [GO:0001569]; cell differentiation [GO:0030154]; in utero embryonic development [GO:0001701]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; platelet activation [GO:0030168]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of blood pressure [GO:0008217]; regulation of cell shape [GO:0008360]; regulation of fibroblast migration [GO:0010762]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10747909}; Lipid-anchor {ECO:0000269|PubMed:10747909}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm {ECO:0000269|PubMed:10747909, ECO:0000269|PubMed:18703424}. Nucleus {ECO:0000269|PubMed:18703424}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (PubMed:18703424). In round spermatids, also present in the nuclei (PubMed:18703424). {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18703424}.
Q14353	reviewed	GAMT_HUMAN	Guanidinoacetate N-methyltransferase (EC 2.1.1.2)	GAMT	Homo sapiens (Human)	236	FUNCTION: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor (PubMed:26003046, PubMed:24415674, PubMed:26319512). Important in nervous system development (PubMed:24415674). {ECO:0000269|PubMed:24415674, ECO:0000269|PubMed:26003046, ECO:0000269|PubMed:26319512}.		animal organ morphogenesis [GO:0009887]; creatine biosynthetic process [GO:0006601]; creatine metabolic process [GO:0006600]; methylation [GO:0032259]; muscle contraction [GO:0006936]; regulation of multicellular organism growth [GO:0040014]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	guanidinoacetate N-methyltransferase activity [GO:0030731]; methyltransferase activity [GO:0008168]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; guanidinoacetate N-methyltransferase activity [GO:0030731]; methyltransferase activity [GO:0008168]; animal organ morphogenesis [GO:0009887]; creatine biosynthetic process [GO:0006601]; creatine metabolic process [GO:0006600]; methylation [GO:0032259]; muscle contraction [GO:0006936]; regulation of multicellular organism growth [GO:0040014]; spermatogenesis [GO:0007283]	
Q14376	reviewed	GALE_HUMAN	UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase)	GALE	Homo sapiens (Human)	348	FUNCTION: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. {ECO:0000269|PubMed:22654673, ECO:0000303|PubMed:23732289}.	MISCELLANEOUS: Contrary to the human enzyme, the E.coli ortholog (AC P09147) does not catalyze the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. Compared to the E.coli enzyme, the sugar-binding pocket of the active site is 15% larger for the human enzyme, making it possible to accommodate the acetyl group. {ECO:0000269|PubMed:11279032}.	galactose catabolic process [GO:0019388]; galactose catabolic process via UDP-galactose [GO:0033499]	cytosol [GO:0005829]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; UDP-glucose 4-epimerase activity [GO:0003978]; UDP-N-acetylglucosamine 4-epimerase activity [GO:0003974]	cytosol [GO:0005829]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; UDP-glucose 4-epimerase activity [GO:0003978]; UDP-N-acetylglucosamine 4-epimerase activity [GO:0003974]; galactose catabolic process [GO:0019388]; galactose catabolic process via UDP-galactose [GO:0033499]	
Q14392	reviewed	LRC32_HUMAN	Transforming growth factor beta activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32)	LRRC32 D11S833E	Homo sapiens (Human)	662	FUNCTION: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity). {ECO:0000250|UniProtKB:G3XA59, ECO:0000269|PubMed:19651619, ECO:0000269|PubMed:19750484, ECO:0000269|PubMed:22278742}.		negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of cytokine production [GO:0001818]; positive regulation of gene expression [GO:0010628]; regulation of transforming growth factor beta activation [GO:1901388]; regulation of transforming growth factor beta3 activation [GO:1901398]; secondary palate development [GO:0062009]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	transforming growth factor beta binding [GO:0050431]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; transforming growth factor beta binding [GO:0050431]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of cytokine production [GO:0001818]; positive regulation of gene expression [GO:0010628]; regulation of transforming growth factor beta activation [GO:1901388]; regulation of transforming growth factor beta3 activation [GO:1901398]; secondary palate development [GO:0062009]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19651619, ECO:0000269|PubMed:19750484}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000269|PubMed:19651619, ECO:0000269|PubMed:19750484}.
Q14393	reviewed	GAS6_HUMAN	Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand)	GAS6 AXLLG	Homo sapiens (Human)	678	FUNCTION: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688). {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:23084921}.		activation of protein kinase B activity [GO:0032148]; animal organ regeneration [GO:0031100]; apoptotic cell clearance [GO:0043277]; B cell chemotaxis [GO:0035754]; blood coagulation [GO:0007596]; calcium ion transmembrane transport [GO:0070588]; cell-substrate adhesion [GO:0031589]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cellular response to interferon-alpha [GO:0035457]; cellular response to starvation [GO:0009267]; cellular response to vitamin K [GO:0071307]; cellular response to xenobiotic stimulus [GO:0071466]; dendritic cell differentiation [GO:0097028]; extracellular matrix assembly [GO:0085029]; fibroblast apoptotic process [GO:0044346]; fusion of virus membrane with host plasma membrane [GO:0019064]; hematopoietic stem cell migration to bone marrow [GO:0097241]; myeloid cell apoptotic process [GO:0033028]; negative regulation of apoptotic process [GO:0043066]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of oligodendrocyte apoptotic process [GO:1900142]; negative regulation of renal albumin absorption [GO:2000533]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type II interferon production [GO:0032689]; neuron migration [GO:0001764]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of TOR signaling [GO:0032008]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; receptor-mediated virion attachment to host cell [GO:0046813]; signal transduction [GO:0007165]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; viral entry into host cell [GO:0046718]; viral genome replication [GO:0019079]	cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; platelet alpha granule lumen [GO:0031093]	calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; phosphatidylserine binding [GO:0001786]; protein tyrosine kinase activator activity [GO:0030296]; protein-macromolecule adaptor activity [GO:0030674]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; platelet alpha granule lumen [GO:0031093]; calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; phosphatidylserine binding [GO:0001786]; protein tyrosine kinase activator activity [GO:0030296]; protein-macromolecule adaptor activity [GO:0030674]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; activation of protein kinase B activity [GO:0032148]; animal organ regeneration [GO:0031100]; apoptotic cell clearance [GO:0043277]; B cell chemotaxis [GO:0035754]; blood coagulation [GO:0007596]; calcium ion transmembrane transport [GO:0070588]; cell-substrate adhesion [GO:0031589]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cellular response to interferon-alpha [GO:0035457]; cellular response to starvation [GO:0009267]; cellular response to vitamin K [GO:0071307]; cellular response to xenobiotic stimulus [GO:0071466]; dendritic cell differentiation [GO:0097028]; extracellular matrix assembly [GO:0085029]; fibroblast apoptotic process [GO:0044346]; fusion of virus membrane with host plasma membrane [GO:0019064]; hematopoietic stem cell migration to bone marrow [GO:0097241]; myeloid cell apoptotic process [GO:0033028]; negative regulation of apoptotic process [GO:0043066]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of oligodendrocyte apoptotic process [GO:1900142]; negative regulation of renal albumin absorption [GO:2000533]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type II interferon production [GO:0032689]; neuron migration [GO:0001764]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of TOR signaling [GO:0032008]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; receptor-mediated virion attachment to host cell [GO:0046813]; signal transduction [GO:0007165]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; viral entry into host cell [GO:0046718]; viral genome replication [GO:0019079]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9326369}.
Q14397	reviewed	GCKR_HUMAN	Glucokinase regulatory protein (GKRP) (Glucokinase regulator)	GCKR	Homo sapiens (Human)	625	FUNCTION: Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23621087, PubMed:23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23621087, PubMed:23733961). {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:23621087, ECO:0000269|PubMed:23733961}.		carbohydrate derivative metabolic process [GO:1901135]; carbohydrate metabolic process [GO:0005975]; glucose homeostasis [GO:0042593]; negative regulation of glucokinase activity [GO:0033132]; protein import into nucleus [GO:0006606]; response to fructose [GO:0009750]; triglyceride homeostasis [GO:0070328]; urate metabolic process [GO:0046415]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	carbohydrate binding [GO:0030246]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; fructose-6-phosphate binding [GO:0070095]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; carbohydrate binding [GO:0030246]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; fructose-6-phosphate binding [GO:0070095]; carbohydrate derivative metabolic process [GO:1901135]; carbohydrate metabolic process [GO:0005975]; glucose homeostasis [GO:0042593]; negative regulation of glucokinase activity [GO:0033132]; protein import into nucleus [GO:0006606]; response to fructose [GO:0009750]; triglyceride homeostasis [GO:0070328]; urate metabolic process [GO:0046415]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Mitochondrion {ECO:0000250|UniProtKB:Q07071}. Note=Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000269|PubMed:10456334}.
Q14406	reviewed	CSHL_HUMAN	Chorionic somatomammotropin hormone-like 1 (Chorionic somatomammotropin-like) (Lactogen-like)	CSHL1 CSHP1 CSL	Homo sapiens (Human)	222	FUNCTION: May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation. {ECO:0000269|PubMed:8083227}.		animal organ development [GO:0048513]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of growth [GO:0045927]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to nutrient levels [GO:0031667]	extracellular space [GO:0005615]	growth factor activity [GO:0008083]; growth hormone receptor binding [GO:0005131]; hormone activity [GO:0005179]; metal ion binding [GO:0046872]	extracellular space [GO:0005615]; growth factor activity [GO:0008083]; growth hormone receptor binding [GO:0005131]; hormone activity [GO:0005179]; metal ion binding [GO:0046872]; animal organ development [GO:0048513]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of growth [GO:0045927]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to nutrient levels [GO:0031667]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8083227}.
Q14410	reviewed	GLPK2_HUMAN	Glycerol kinase 2 (GK 2) (Glycerokinase 2) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 2) (Glycerol kinase, testis specific 2)	GK2 GKP2 GKTA	Homo sapiens (Human)	553	FUNCTION: Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation (By similarity). Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis (By similarity). Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria (PubMed:28852571). {ECO:0000250|UniProtKB:Q9WU65, ECO:0000269|PubMed:28852571}.		flagellated sperm motility [GO:0030317]; glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; glycerol-3-phosphate biosynthetic process [GO:0046167]; phosphorylation [GO:0016310]; sperm mitochondrial sheath assembly [GO:0120317]; spermatogenesis [GO:0007283]; triglyceride metabolic process [GO:0006641]	extracellular exosome [GO:0070062]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; sperm midpiece [GO:0097225]; sperm mitochondrial sheath [GO:0097226]	ATP binding [GO:0005524]; glycerol kinase activity [GO:0004370]	extracellular exosome [GO:0070062]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; sperm midpiece [GO:0097225]; sperm mitochondrial sheath [GO:0097226]; ATP binding [GO:0005524]; glycerol kinase activity [GO:0004370]; flagellated sperm motility [GO:0030317]; glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; glycerol-3-phosphate biosynthetic process [GO:0046167]; phosphorylation [GO:0016310]; sperm mitochondrial sheath assembly [GO:0120317]; spermatogenesis [GO:0007283]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9WU65}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9WU65}. Cytoplasm {ECO:0000250}. Note=In sperm the majority of the enzyme is bound to mitochondria. {ECO:0000250|UniProtKB:Q9WU65}.
Q14416	reviewed	GRM2_HUMAN	Metabotropic glutamate receptor 2 (mGluR2)	GRM2 GPRC1B MGLUR2	Homo sapiens (Human)	872	FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. {ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:23129762, ECO:0000269|PubMed:7620613}.		behavioral response to nicotine [GO:0035095]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; glutamate secretion [GO:0014047]; intracellular glutamate homeostasis [GO:0090461]; long-term synaptic depression [GO:0060292]; negative regulation of adenylate cyclase activity [GO:0007194]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; regulation of glutamate secretion [GO:0014048]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of response to drug [GO:2001023]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to cocaine [GO:0042220]	astrocyte projection [GO:0097449]; axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	calcium channel regulator activity [GO:0005246]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110]	astrocyte projection [GO:0097449]; axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; calcium channel regulator activity [GO:0005246]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110]; behavioral response to nicotine [GO:0035095]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; glutamate secretion [GO:0014047]; intracellular glutamate homeostasis [GO:0090461]; long-term synaptic depression [GO:0060292]; negative regulation of adenylate cyclase activity [GO:0007194]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; regulation of glutamate secretion [GO:0014048]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of response to drug [GO:2001023]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to cocaine [GO:0042220]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Synapse {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
Q14432	reviewed	PDE3A_HUMAN	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)	PDE3A	Homo sapiens (Human)	1141	FUNCTION: Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:8695850, PubMed:8155697, PubMed:25961942). Has also activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}.		apoptotic signaling pathway [GO:0097190]; cAMP-mediated signaling [GO:0019933]; cellular response to cGMP [GO:0071321]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cGMP-mediated signaling [GO:0019934]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of vascular permeability [GO:0043116]; oocyte maturation [GO:0001556]; positive regulation of oocyte development [GO:0060282]; positive regulation of vascular permeability [GO:0043117]; regulation of meiotic nuclear division [GO:0040020]; regulation of ribonuclease activity [GO:0060700]; response to xenobiotic stimulus [GO:0009410]	cytosol [GO:0005829]; membrane [GO:0016020]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; estrogen binding [GO:0099130]; metal ion binding [GO:0046872]; nuclear estrogen receptor activity [GO:0030284]	cytosol [GO:0005829]; membrane [GO:0016020]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; estrogen binding [GO:0099130]; metal ion binding [GO:0046872]; nuclear estrogen receptor activity [GO:0030284]; apoptotic signaling pathway [GO:0097190]; cAMP-mediated signaling [GO:0019933]; cellular response to cGMP [GO:0071321]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cGMP-mediated signaling [GO:0019934]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of vascular permeability [GO:0043116]; oocyte maturation [GO:0001556]; positive regulation of oocyte development [GO:0060282]; positive regulation of vascular permeability [GO:0043117]; regulation of meiotic nuclear division [GO:0040020]; regulation of ribonuclease activity [GO:0060700]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9Z0X4}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000269|PubMed:35104454}.
Q14435	reviewed	GALT3_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 3 (EC 2.4.1.41) (Polypeptide GalNAc transferase 3) (GalNAc-T3) (pp-GaNTase 3) (Protein-UDP acetylgalactosaminyltransferase 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3)	GALNT3	Homo sapiens (Human)	633	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:8663203, PubMed:9295285, PubMed:16638743, PubMed:31932717). Has activity toward HIV envelope glycoprotein gp120, EA2, MUC2, MUC1A and MUC5AC (PubMed:8663203, PubMed:9295285). Probably glycosylates fibronectin in vivo (PubMed:9295285). Glycosylates FGF23 (PubMed:16638743, PubMed:31932717). {ECO:0000269|PubMed:16638743, ECO:0000269|PubMed:31932717, ECO:0000269|PubMed:8663203, ECO:0000269|PubMed:9295285}.	MISCELLANEOUS: Overexpressed in many differentiated carcinomas, suggesting that it may serve as a marker of tumor differentiation.	carbohydrate metabolic process [GO:0005975]; fibroblast growth factor receptor signaling pathway [GO:0008543]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]; spermatogenesis [GO:0007283]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; carbohydrate metabolic process [GO:0005975]; fibroblast growth factor receptor signaling pathway [GO:0008543]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:9394011}; Single-pass type II membrane protein {ECO:0000269|PubMed:9394011}. Note=Resides preferentially in the trans and medial parts of the Golgi stack.
Q14442	reviewed	PIGH_HUMAN	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H)	PIGH	Homo sapiens (Human)	188	FUNCTION: Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. {ECO:0000269|PubMed:16162815, ECO:0000269|PubMed:9463366}.		GPI anchor biosynthetic process [GO:0006506]; protein modification process [GO:0036211]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]	catalytic activity [GO:0003824]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; catalytic activity [GO:0003824]; GPI anchor biosynthetic process [GO:0006506]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cytoplasm.
Q14444	reviewed	CAPR1_HUMAN	Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105)	CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105	Homo sapiens (Human)	709	FUNCTION: mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}.		cell differentiation [GO:0030154]; negative regulation of translation [GO:0017148]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of stress granule assembly [GO:0062029]; regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0106288]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular non-membrane-bounded organelle [GO:0043232]; lamellipodium [GO:0030027]; membrane [GO:0016020]; P-body [GO:0000932]; synapse [GO:0045202]	ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; molecular function activator activity [GO:0140677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling adaptor activity [GO:0035591]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular non-membrane-bounded organelle [GO:0043232]; lamellipodium [GO:0030027]; membrane [GO:0016020]; P-body [GO:0000932]; synapse [GO:0045202]; ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; molecular function activator activity [GO:0140677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling adaptor activity [GO:0035591]; cell differentiation [GO:0030154]; negative regulation of translation [GO:0017148]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of stress granule assembly [GO:0062029]; regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0106288]	SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799}. Cytoplasm, cytosol {ECO:0000269|PubMed:28733330}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q5M9G3}. Cell projection, lamellipodium {ECO:0000269|PubMed:28733330}. Note=Mediates formation and localizes to cytoplasmic ribonucleoprotein membraneless compartments (PubMed:31439799). Associated with RNA granules. At the leading edge of migrating fibroblasts, colocalizes with DDX3X (PubMed:28733330). {ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:31439799}.
Q14449	reviewed	GRB14_HUMAN	Growth factor receptor-bound protein 14 (GRB14 adapter protein)	GRB14	Homo sapiens (Human)	540	FUNCTION: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}.		insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	molecular adaptor activity [GO:0060090]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; molecular adaptor activity [GO:0060090]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971]; insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}. Endosome membrane {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}; Peripheral membrane protein {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}. Note=Upon insulin stimulation, translocates to the plasma membrane. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}.
Q14451	reviewed	GRB7_HUMAN	Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)	GRB7	Homo sapiens (Human)	532	FUNCTION: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}.		epidermal growth factor receptor signaling pathway [GO:0007173]; negative regulation of translation [GO:0017148]; positive regulation of cell migration [GO:0030335]; stress granule assembly [GO:0034063]	cell projection [GO:0042995]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]	cell projection [GO:0042995]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; epidermal growth factor receptor signaling pathway [GO:0007173]; negative regulation of translation [GO:0017148]; positive regulation of cell migration [GO:0030335]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:18853468}. Cell junction, focal adhesion {ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278}. Cell membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:18853468}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q03160}. Cell projection {ECO:0000269|PubMed:18853468}. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions. {ECO:0000250|UniProtKB:Q03160}.
Q14457	reviewed	BECN1_HUMAN	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]	BECN1 GT197	Homo sapiens (Human)	450	FUNCTION: Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:28445460, PubMed:25484083). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:23974797, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. {ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23974797, ECO:0000269|PubMed:25275521, ECO:0000269|PubMed:25484083, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:9765397, ECO:0000305}.; FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. {ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:26263979}.	MISCELLANEOUS: Expanded poly-Gln tracts inhibit ATXN3-BECN1 interaction, decrease BECN1 levels and impair starvation-induced autophagy (PubMed:28445460). {ECO:0000269|PubMed:28445460}.	amyloid-beta metabolic process [GO:0050435]; apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cell division [GO:0051301]; cellular defense response [GO:0006968]; cellular response to aluminum ion [GO:0071275]; cellular response to amino acid starvation [GO:0034198]; cellular response to copper ion [GO:0071280]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to nitrogen starvation [GO:0006995]; defense response to virus [GO:0051607]; early endosome to late endosome transport [GO:0045022]; engulfment of apoptotic cell [GO:0043652]; late endosome to vacuole transport [GO:0045324]; lysosome organization [GO:0007040]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of lysosome organization [GO:1905672]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neuron development [GO:0048666]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein targeting to lysosome [GO:0006622]; protein-containing complex assembly [GO:0065003]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]; response to hypoxia [GO:0001666]; response to iron(II) ion [GO:0010040]; response to lead ion [GO:0010288]; response to mitochondrial depolarisation [GO:0098780]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; selective autophagy [GO:0061912]; suppression by virus of host autophagy [GO:0039521]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; nuclear body [GO:0016604]; phagocytic vesicle [GO:0045335]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]; trans-Golgi network [GO:0005802]	GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase binding [GO:0031625]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; nuclear body [GO:0016604]; phagocytic vesicle [GO:0045335]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]; trans-Golgi network [GO:0005802]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase binding [GO:0031625]; amyloid-beta metabolic process [GO:0050435]; apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cell division [GO:0051301]; cellular defense response [GO:0006968]; cellular response to aluminum ion [GO:0071275]; cellular response to amino acid starvation [GO:0034198]; cellular response to copper ion [GO:0071280]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to nitrogen starvation [GO:0006995]; defense response to virus [GO:0051607]; early endosome to late endosome transport [GO:0045022]; engulfment of apoptotic cell [GO:0043652]; late endosome to vacuole transport [GO:0045324]; lysosome organization [GO:0007040]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of lysosome organization [GO:1905672]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neuron development [GO:0048666]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein targeting to lysosome [GO:0006622]; protein-containing complex assembly [GO:0065003]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]; response to hypoxia [GO:0001666]; response to iron(II) ion [GO:0010040]; response to lead ion [GO:0010288]; response to mitochondrial depolarisation [GO:0098780]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; selective autophagy [GO:0061912]; suppression by virus of host autophagy [GO:0039521]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19713971, ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:22498477, ECO:0000269|PubMed:25484083}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19050071}; Peripheral membrane protein {ECO:0000269|PubMed:19050071}. Endosome membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Mitochondrion membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Endosome {ECO:0000250|UniProtKB:O88597}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). {ECO:0000250|UniProtKB:O88597, ECO:0000269|PubMed:19050071}.; SUBCELLULAR LOCATION: [Beclin-1-C 35 kDa]: Mitochondrion {ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:26263979}. Nucleus {ECO:0000269|PubMed:19713971}. Cytoplasm {ECO:0000269|PubMed:19713971}.; SUBCELLULAR LOCATION: [Beclin-1-C 37 kDa]: Mitochondrion {ECO:0000250|UniProtKB:O88597}.
Q14469	reviewed	HES1_HUMAN	Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL)	HES1 BHLHB39 HL HRY	Homo sapiens (Human)	280	FUNCTION: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}.		adenohypophysis development [GO:0021984]; amacrine cell differentiation [GO:0035881]; anterior/posterior pattern specification [GO:0009952]; artery morphogenesis [GO:0048844]; ascending aorta morphogenesis [GO:0035910]; BMP signaling pathway [GO:0030509]; Cajal-Retzius cell differentiation [GO:0021870]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cell adhesion [GO:0007155]; cell fate determination [GO:0001709]; cell maturation [GO:0048469]; cell migration [GO:0016477]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to fatty acid [GO:0071398]; cellular response to interleukin-1 [GO:0071347]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; cochlea development [GO:0090102]; comma-shaped body morphogenesis [GO:0072049]; common bile duct development [GO:0061009]; embryonic heart tube morphogenesis [GO:0003143]; establishment of epithelial cell polarity [GO:0090162]; forebrain radial glial cell differentiation [GO:0021861]; glomerulus vasculature development [GO:0072012]; hindbrain morphogenesis [GO:0021575]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell stereocilium organization [GO:0060122]; labyrinthine layer blood vessel development [GO:0060716]; lateral inhibition [GO:0046331]; liver development [GO:0001889]; lung development [GO:0030324]; metanephric nephron tubule morphogenesis [GO:0072282]; midbrain development [GO:0030901]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; negative regulation of amacrine cell differentiation [GO:1902870]; negative regulation of calcium ion import [GO:0090281]; negative regulation of cell fate determination [GO:1905934]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of forebrain neuron differentiation [GO:2000978]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of pancreatic A cell differentiation [GO:2000227]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of stomach neuroendocrine cell differentiation [GO:0061106]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; oculomotor nerve development [GO:0021557]; outflow tract morphogenesis [GO:0003151]; pancreatic A cell differentiation [GO:0003310]; pharyngeal arch artery morphogenesis [GO:0061626]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic cell cycle, embryonic [GO:0045977]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein-containing complex assembly [GO:0065003]; regulation of epithelial cell proliferation [GO:0050678]; regulation of fat cell differentiation [GO:0045598]; regulation of neurogenesis [GO:0050767]; regulation of protein-containing complex assembly [GO:0043254]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; regulation of timing of neuron differentiation [GO:0060164]; regulation of transcription by RNA polymerase II [GO:0006357]; renal interstitial fibroblast development [GO:0072141]; response to alkaloid [GO:0043279]; response to organic cyclic compound [GO:0014070]; response to thyroid hormone [GO:0097066]; S-shaped body morphogenesis [GO:0072050]; smoothened signaling pathway [GO:0007224]; somatic stem cell population maintenance [GO:0035019]; stomach neuroendocrine cell differentiation [GO:0061102]; T cell proliferation [GO:0042098]; telencephalon development [GO:0021537]; thymus development [GO:0048538]; trochlear nerve development [GO:0021558]; ureteric bud morphogenesis [GO:0060675]; vascular associated smooth muscle cell development [GO:0097084]; ventricular septum development [GO:0003281]; ventricular septum morphogenesis [GO:0060412]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; HLH domain binding [GO:0043398]; JUN kinase binding [GO:0008432]; N-box binding [GO:0071820]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; HLH domain binding [GO:0043398]; JUN kinase binding [GO:0008432]; N-box binding [GO:0071820]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]; adenohypophysis development [GO:0021984]; amacrine cell differentiation [GO:0035881]; anterior/posterior pattern specification [GO:0009952]; artery morphogenesis [GO:0048844]; ascending aorta morphogenesis [GO:0035910]; BMP signaling pathway [GO:0030509]; Cajal-Retzius cell differentiation [GO:0021870]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cell adhesion [GO:0007155]; cell fate determination [GO:0001709]; cell maturation [GO:0048469]; cell migration [GO:0016477]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to fatty acid [GO:0071398]; cellular response to interleukin-1 [GO:0071347]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; cochlea development [GO:0090102]; comma-shaped body morphogenesis [GO:0072049]; common bile duct development [GO:0061009]; embryonic heart tube morphogenesis [GO:0003143]; establishment of epithelial cell polarity [GO:0090162]; forebrain radial glial cell differentiation [GO:0021861]; glomerulus vasculature development [GO:0072012]; hindbrain morphogenesis [GO:0021575]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell stereocilium organization [GO:0060122]; labyrinthine layer blood vessel development [GO:0060716]; lateral inhibition [GO:0046331]; liver development [GO:0001889]; lung development [GO:0030324]; metanephric nephron tubule morphogenesis [GO:0072282]; midbrain development [GO:0030901]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; negative regulation of amacrine cell differentiation [GO:1902870]; negative regulation of calcium ion import [GO:0090281]; negative regulation of cell fate determination [GO:1905934]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of forebrain neuron differentiation [GO:2000978]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of pancreatic A cell differentiation [GO:2000227]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of stomach neuroendocrine cell differentiation [GO:0061106]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; oculomotor nerve development [GO:0021557]; outflow tract morphogenesis [GO:0003151]; pancreatic A cell differentiation [GO:0003310]; pharyngeal arch artery morphogenesis [GO:0061626]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic cell cycle, embryonic [GO:0045977]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein-containing complex assembly [GO:0065003]; regulation of epithelial cell proliferation [GO:0050678]; regulation of fat cell differentiation [GO:0045598]; regulation of neurogenesis [GO:0050767]; regulation of protein-containing complex assembly [GO:0043254]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; regulation of timing of neuron differentiation [GO:0060164]; regulation of transcription by RNA polymerase II [GO:0006357]; renal interstitial fibroblast development [GO:0072141]; response to alkaloid [GO:0043279]; response to organic cyclic compound [GO:0014070]; response to thyroid hormone [GO:0097066]; S-shaped body morphogenesis [GO:0072050]; smoothened signaling pathway [GO:0007224]; somatic stem cell population maintenance [GO:0035019]; stomach neuroendocrine cell differentiation [GO:0061102]; T cell proliferation [GO:0042098]; telencephalon development [GO:0021537]; thymus development [GO:0048538]; trochlear nerve development [GO:0021558]; ureteric bud morphogenesis [GO:0060675]; vascular associated smooth muscle cell development [GO:0097084]; ventricular septum development [GO:0003281]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28750047}.
Q14493	reviewed	SLBP_HUMAN	Histone RNA hairpin-binding protein (Histone stem-loop-binding protein)	SLBP HBP	Homo sapiens (Human)	270	FUNCTION: RNA-binding protein involved in the histone pre-mRNA processing (PubMed:8957003, PubMed:9049306, PubMed:12588979, PubMed:19155325). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:8957003, PubMed:9049306, PubMed:12588979, PubMed:19155325). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:8957003, PubMed:9049306, PubMed:12588979, PubMed:19155325). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:8957003, PubMed:9049306, PubMed:12588979, PubMed:19155325). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). {ECO:0000250|UniProtKB:P97440, ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:19155325, ECO:0000269|PubMed:8957003, ECO:0000269|PubMed:9049306}.		cap-dependent translational initiation [GO:0002191]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; mRNA transport [GO:0051028]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone mRNA stem-loop binding complex [GO:0062073]; histone pre-mRNA 3'end processing complex [GO:0071204]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	histone pre-mRNA DCP binding [GO:0071208]; histone pre-mRNA stem-loop binding [GO:0071207]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone mRNA stem-loop binding complex [GO:0062073]; histone pre-mRNA 3'end processing complex [GO:0071204]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; histone pre-mRNA DCP binding [GO:0071208]; histone pre-mRNA stem-loop binding [GO:0071207]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; cap-dependent translational initiation [GO:0002191]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; mRNA transport [GO:0051028]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:15829567}. Nucleus {ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:15829567}. Note=Polyribosome-associated (PubMed:12588979). Localizes predominantly in the nucleus at the G1/G2 phases and the beginning of S phase (PubMed:12588979). Through the S phase, partially redistributes to the cytoplasm (PubMed:12588979). Binding to histone mRNA is necessary for cytoplasmic localization (PubMed:12588979). Shuttles between the nucleus and the cytoplasm (PubMed:15829567). Imported in the nucleus by the Importin alpha/Importin beta receptor (PubMed:15829567). {ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:15829567}.
Q14494	reviewed	NF2L1_HUMAN	Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)]	NFE2L1 HBZ17 NRF1 TCF11	Homo sapiens (Human)	772	FUNCTION: [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20932482). {ECO:0000250|UniProtKB:Q61985, ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:24448410}.; FUNCTION: [Transcription factor NRF1]: CNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses (PubMed:8932385, PubMed:9421508). Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response (PubMed:8932385, PubMed:9421508). Activates or represses expression of target genes, depending on the context (PubMed:8932385, PubMed:9421508). Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess, such as CD36 (By similarity). In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes, such as GCLC, GCLM, GSS, MT1 and MT2 (By similarity). Plays an essential role during fetal liver hematopoiesis: probably has a protective function against oxidative stress and is involved in lipid homeostasis in the liver (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (PubMed:20932482). Also involved in regulating glucose flux (By similarity). Together with CEBPB; represses expression of DSPP during odontoblast differentiation (PubMed:15308669). In response to ascorbic acid induction, activates expression of SP7/Osterix in osteoblasts. {ECO:0000250|UniProtKB:Q61985, ECO:0000269|PubMed:15308669, ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9421508}.		anatomical structure morphogenesis [GO:0009653]; cholesterol metabolic process [GO:0008203]; heme biosynthetic process [GO:0006783]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cholesterol metabolic process [GO:0008203]; heme biosynthetic process [GO:0006783]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16687406, ECO:0000269|PubMed:24448410, ECO:0000269|PubMed:24998528}; Single-pass type II membrane protein {ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:24448410}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16687406, ECO:0000269|PubMed:24448410, ECO:0000269|PubMed:24998528}; Single-pass type III membrane protein {ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:24448410}. Note=In normal conditions, probably has a single-pass type II membrane protein topology, with the DNA-binding domain facing the endoplasmic reticulum lumen (PubMed:24448410). Following cellular stress, it is rapidly and efficiently retrotranslocated to the cytosolic side of the membrane, a process dependent on p97/VCP, to have a single-pass type III membrane protein topology with the major part of the protein facing the cytosol (PubMed:24448410). Retrotranslocated proteins are normally rapidly degraded by the proteasome and active species do not accumulate (PubMed:24448410). However, retrotranslocated protein NFE2L1 escapes degradation and is cleaved at Leu-104 by DDI2, releasing the protein from the endoplasmic reticulum membrane and forming the transcription factor NRF1 that translocates into the nucleus (PubMed:24448410). {ECO:0000269|PubMed:24448410}.; SUBCELLULAR LOCATION: [Transcription factor NRF1]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:16687406, ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:24998528, ECO:0000269|PubMed:27528193}. Note=Translocates into the nucleus following cleavage of Endoplasmic reticulum membrane sensor NFE2L1 by aspartyl protease DDI2. {ECO:0000269|PubMed:24448410, ECO:0000269|PubMed:27528193}.
Q14498	reviewed	RBM39_HUMAN	RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1)	RBM39 HCC1 RNPC2	Homo sapiens (Human)	530	FUNCTION: RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:31271494, PubMed:28437394, PubMed:28302793, PubMed:24795046). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}.	MISCELLANEOUS: Antibodies against RBM39 are present in sera from a patient with hepatocellular carcinoma who developed several autoantibodies. {ECO:0000269|PubMed:8227358}.	mRNA processing [GO:0006397]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	centriolar satellite [GO:0034451]; microtubule cytoskeleton [GO:0015630]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	RNA binding [GO:0003723]; RS domain binding [GO:0050733]; U1 snRNP binding [GO:1990446]	centriolar satellite [GO:0034451]; microtubule cytoskeleton [GO:0015630]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]; RS domain binding [GO:0050733]; U1 snRNP binding [GO:1990446]; mRNA processing [GO:0006397]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:8227358}. Note=Concentrated in nuclear speckles (PubMed:8227358). Colocalizes with the core spliceosomal snRNP proteins (PubMed:8227358). {ECO:0000269|PubMed:8227358}.
Q14500	reviewed	KCJ12_HUMAN	ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Inward rectifier K(+) channel Kir2.2v) (Potassium channel, inwardly rectifying subfamily J member 12)	KCNJ12 IRK2 KCNJN1	Homo sapiens (Human)	433	FUNCTION: Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000269|PubMed:12417321, ECO:0000269|PubMed:20921230, ECO:0000269|PubMed:7859381, ECO:0000269|PubMed:8647284}.		muscle contraction [GO:0006936]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of heart contraction [GO:0008016]; regulation of monoatomic ion transmembrane transport [GO:0034765]	membrane [GO:0016020]; plasma membrane [GO:0005886]	inward rectifier potassium channel activity [GO:0005242]	membrane [GO:0016020]; plasma membrane [GO:0005886]; inward rectifier potassium channel activity [GO:0005242]; muscle contraction [GO:0006936]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of heart contraction [GO:0008016]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Q14508	reviewed	WFDC2_HUMAN	WAP four-disulfide core domain protein 2 (Epididymal secretory protein E4) (Major epididymis-specific protein E4) (Putative protease inhibitor WAP5)	WFDC2 HE4 WAP5	Homo sapiens (Human)	124	FUNCTION: Broad range protease inhibitor. {ECO:0000269|PubMed:23139753}.		antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	aspartic-type endopeptidase inhibitor activity [GO:0019828]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15781627, ECO:0000269|PubMed:23139753}.
Q14511	reviewed	CASL_HUMAN	Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]	NEDD9 CASL	Homo sapiens (Human)	834	FUNCTION: Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). {ECO:0000250|UniProtKB:A0A8I3PDQ1, ECO:0000250|UniProtKB:O35177, ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:9020138}.		actin filament bundle assembly [GO:0051017]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell migration [GO:0016477]; cilium disassembly [GO:0061523]; cytoskeleton organization [GO:0007010]; integrin-mediated signaling pathway [GO:0007229]; learning or memory [GO:0007611]; lymphocyte migration into lymphoid organs [GO:0097021]; negative regulation of cell migration [GO:0030336]; positive regulation of cell migration [GO:0030335]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of immunological synapse formation [GO:2000522]; positive regulation of lymphocyte chemotaxis [GO:0140131]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of protein localization [GO:1903829]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; lamellipodium [GO:0030027]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle pole [GO:0000922]	protein tyrosine kinase binding [GO:1990782]	basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; lamellipodium [GO:0030027]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle pole [GO:0000922]; protein tyrosine kinase binding [GO:1990782]; actin filament bundle assembly [GO:0051017]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell migration [GO:0016477]; cilium disassembly [GO:0061523]; cytoskeleton organization [GO:0007010]; integrin-mediated signaling pathway [GO:0007229]; learning or memory [GO:0007611]; lymphocyte migration into lymphoid organs [GO:0097021]; negative regulation of cell migration [GO:0030336]; positive regulation of cell migration [GO:0030335]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of immunological synapse formation [GO:2000522]; positive regulation of lymphocyte chemotaxis [GO:0140131]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of protein localization [GO:1903829]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:11827972}. Nucleus {ECO:0000269|PubMed:29899023, ECO:0000269|PubMed:8668148, ECO:0000269|PubMed:9584194}. Golgi apparatus {ECO:0000269|PubMed:8668148}. Cell projection, lamellipodium {ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:8668148}. Cytoplasm {ECO:0000269|PubMed:11827972, ECO:0000269|PubMed:9584194}. Cell junction, focal adhesion {ECO:0000269|PubMed:19103205, ECO:0000269|PubMed:19275884, ECO:0000269|PubMed:29191835, ECO:0000269|PubMed:8668148}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11827972}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16394104, ECO:0000269|PubMed:9584194}. Cell projection, cilium {ECO:0000269|PubMed:17604723}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17604723}. Basolateral cell membrane {ECO:0000250|UniProtKB:A0A8I3PDQ1}.; SUBCELLULAR LOCATION: [Enhancer of filamentation 1 p55]: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9584194}.
Q14512	reviewed	FGFP1_HUMAN	Fibroblast growth factor-binding protein 1 (FGF-BP) (FGF-BP1) (FGF-binding protein 1) (FGFBP-1) (17 kDa heparin-binding growth factor-binding protein) (17 kDa HBGF-binding protein) (HBp17)	FGFBP1 FGFBP HBP17	Homo sapiens (Human)	234	FUNCTION: Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. {ECO:0000269|PubMed:11509569, ECO:0000269|PubMed:15806171, ECO:0000269|PubMed:1885605, ECO:0000269|PubMed:9334727}.	MISCELLANEOUS: Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell carcinomas, some colon cancer cell lines and tumors.	cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; myoblast proliferation [GO:0051450]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of myoblast proliferation [GO:2000288]; signal transduction [GO:0007165]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	fibroblast growth factor binding [GO:0017134]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; fibroblast growth factor binding [GO:0017134]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; myoblast proliferation [GO:0051450]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of myoblast proliferation [GO:2000288]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171}. Cell membrane {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171}; Peripheral membrane protein {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171}. Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas. {ECO:0000269|PubMed:11148217}.
Q14515	reviewed	SPRL1_HUMAN	SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9)	SPARCL1	Homo sapiens (Human)	664			anatomical structure development [GO:0048856]; signal transduction [GO:0007165]; synaptic membrane adhesion [GO:0099560]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]	calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; anatomical structure development [GO:0048856]; signal transduction [GO:0007165]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q14517	reviewed	FAT1_HUMAN	Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]	FAT1 CDHF7 FAT	Homo sapiens (Human)	4588	FUNCTION: [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}.		actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis [GO:0003412]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens development in camera-type eye [GO:0002088]	apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis [GO:0003412]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens development in camera-type eye [GO:0002088]	SUBCELLULAR LOCATION: [Protocadherin Fat 1]: Cell membrane {ECO:0000269|PubMed:15922730}; Single-pass type I membrane protein {ECO:0000269|PubMed:15922730}.; SUBCELLULAR LOCATION: [Protocadherin Fat 1, nuclear form]: Nucleus {ECO:0000269|PubMed:15922730}.
Q14520	reviewed	HABP2_HUMAN	Hyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]	HABP2 HGFAL PHBP	Homo sapiens (Human)	560	FUNCTION: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (PubMed:8827452, PubMed:10754382, PubMed:11217080). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560). {ECO:0000269|PubMed:10754382, ECO:0000269|PubMed:11217080, ECO:0000269|PubMed:26222560, ECO:0000269|PubMed:8827452}.		cell adhesion [GO:0007155]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; cell adhesion [GO:0007155]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8827452}. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
Q14524	reviewed	SCN5A_HUMAN	Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1)	SCN5A	Homo sapiens (Human)	2016	FUNCTION: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1309946, PubMed:21447824, PubMed:25370050, PubMed:23420830, PubMed:23085483, PubMed:26279430, PubMed:26392562, PubMed:26776555). It is a tetrodotoxin-resistant Na(+) channel isoform (PubMed:1309946). This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (PubMed:19074138). {ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}.	MISCELLANEOUS: Na(+) channels in mammalian cardiac membrane have functional properties quite distinct from Na(+) channels in nerve and skeletal muscle.; MISCELLANEOUS: [Isoform 1]: Most abundant isoform in heart.; MISCELLANEOUS: [Isoform 2]: Very abundant isoform. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Abundantly expressed in neonatal brain and heart, slower kinetics of activation and inactivation. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Only detected in neuroblastoma in humans. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: High expression in brain where it accounts for nearly 50% of the total transcripts. Non-functional channel, may exist to limit the number of undesired functional Nav1.5 channels. {ECO:0000305}.	atrial cardiac muscle cell action potential [GO:0086014]; AV node cell action potential [GO:0086016]; AV node cell to bundle of His cell communication [GO:0086067]; brainstem development [GO:0003360]; bundle of His cell action potential [GO:0086043]; calcium ion import across plasma membrane [GO:0098703]; cardiac conduction system development [GO:0003161]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; cardiac ventricle development [GO:0003231]; cellular response to calcium ion [GO:0071277]; cerebellum development [GO:0021549]; membrane depolarization [GO:0051899]; membrane depolarization during action potential [GO:0086010]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; membrane depolarization during SA node cell action potential [GO:0086046]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of action potential [GO:0045760]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of sodium ion transport [GO:0010765]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; SA node cell action potential [GO:0086015]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; telencephalon development [GO:0021537]; ventricular cardiac muscle cell action potential [GO:0086005]	caveola [GO:0005901]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018]	ankyrin binding [GO:0030506]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; high voltage-gated calcium channel activity [GO:0008331]; nitric-oxide synthase binding [GO:0050998]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in AV node cell action potential [GO:0086060]; voltage-gated sodium channel activity involved in bundle of His cell action potential [GO:0086061]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]; voltage-gated sodium channel activity involved in Purkinje myocyte action potential [GO:0086062]; voltage-gated sodium channel activity involved in SA node cell action potential [GO:0086063]	caveola [GO:0005901]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018]; ankyrin binding [GO:0030506]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; high voltage-gated calcium channel activity [GO:0008331]; nitric-oxide synthase binding [GO:0050998]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in AV node cell action potential [GO:0086060]; voltage-gated sodium channel activity involved in bundle of His cell action potential [GO:0086061]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]; voltage-gated sodium channel activity involved in Purkinje myocyte action potential [GO:0086062]; voltage-gated sodium channel activity involved in SA node cell action potential [GO:0086063]; atrial cardiac muscle cell action potential [GO:0086014]; AV node cell action potential [GO:0086016]; AV node cell to bundle of His cell communication [GO:0086067]; brainstem development [GO:0003360]; bundle of His cell action potential [GO:0086043]; calcium ion import across plasma membrane [GO:0098703]; cardiac conduction system development [GO:0003161]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; cardiac ventricle development [GO:0003231]; cellular response to calcium ion [GO:0071277]; cerebellum development [GO:0021549]; membrane depolarization [GO:0051899]; membrane depolarization during action potential [GO:0086010]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; membrane depolarization during SA node cell action potential [GO:0086046]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of action potential [GO:0045760]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of sodium ion transport [GO:0010765]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; SA node cell action potential [GO:0086015]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; telencephalon development [GO:0021537]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21447824}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:P15389}. Cell junction {ECO:0000250|UniProtKB:P15389}. Note=RANGRF promotes trafficking to the cell membrane. Colocalizes with PKP2 at intercalated disks in the heart (By similarity). {ECO:0000250|UniProtKB:P15389, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23420830}.
Q14525	reviewed	KT33B_HUMAN	Keratin, type I cuticular Ha3-II (Hair keratin, type I Ha3-II) (Keratin-33B) (K33B)	KRT33B HHA3-II HKA3B KRTHA3B	Homo sapiens (Human)	404		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	epithelial cell differentiation [GO:0030855]; hair cycle [GO:0042633]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; hair cycle [GO:0042633]; intermediate filament organization [GO:0045109]	
Q14526	reviewed	HIC1_HUMAN	Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29)	HIC1 ZBTB29	Homo sapiens (Human)	733	FUNCTION: Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}.	MISCELLANEOUS: The HIC1 gene is frequently found epigenetically silenced or deleted in different types of solid tumors.	intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11554746}.
Q14527	reviewed	HLTF_HUMAN	Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)	HLTF HIP116A RNF80 SMARCA3 SNF2L3 ZBU1	Homo sapiens (Human)	1009	FUNCTION: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. {ECO:0000250, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:18316726, ECO:0000269|PubMed:18719106, ECO:0000269|PubMed:7876228, ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}.	MISCELLANEOUS: Subject to frequent epigenetic inactivation by promoter methylation in colon cancer.	DNA repair [GO:0006281]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of neurogenesis [GO:0050767]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]	ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; DNA repair [GO:0006281]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of neurogenesis [GO:0050767]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:8672239}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Nuclear localization is stimulated by progesterone. {ECO:0000250}.
Q14532	reviewed	K1H2_HUMAN	Keratin, type I cuticular Ha2 (Hair keratin, type I Ha2) (Keratin-32) (K32)	KRT32 HHA2 HKA2 KRTHA2	Homo sapiens (Human)	448		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
Q14533	reviewed	KRT81_HUMAN	Keratin, type II cuticular Hb1 (Hair keratin K2.9) (Keratin, hair, basic, 1) (Keratin-81) (K81) (Metastatic lymph node 137 gene protein) (MLN 137) (Type II hair keratin Hb1) (Type-II keratin Kb21) (ghHKb1) (ghHb1)	KRT81 KRTHB1 MLN137	Homo sapiens (Human)	505		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; extracellular space [GO:0005615]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular space [GO:0005615]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
Q14534	reviewed	ERG1_HUMAN	Squalene monooxygenase (EC 1.14.14.17) (Squalene epoxidase) (SE)	SQLE ERG1	Homo sapiens (Human)	574	FUNCTION: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. {ECO:0000269|PubMed:10666321, ECO:0000269|PubMed:30626872}.		cholesterol metabolic process [GO:0008203]; lipid droplet formation [GO:0140042]; regulation of cell population proliferation [GO:0042127]; response to organic substance [GO:0010033]; sterol biosynthetic process [GO:0016126]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	FAD binding [GO:0071949]; squalene monooxygenase activity [GO:0004506]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; FAD binding [GO:0071949]; squalene monooxygenase activity [GO:0004506]; cholesterol metabolic process [GO:0008203]; lipid droplet formation [GO:0140042]; regulation of cell population proliferation [GO:0042127]; response to organic substance [GO:0010033]; sterol biosynthetic process [GO:0016126]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:26434806, ECO:0000269|PubMed:28972164, ECO:0000269|PubMed:30626872}; Peripheral membrane protein {ECO:0000269|PubMed:26434806, ECO:0000269|PubMed:28972164}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:26434806}; Peripheral membrane protein {ECO:0000269|PubMed:26434806, ECO:0000269|PubMed:28972164}.
Q14541	reviewed	HNF4G_HUMAN	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma) (Nuclear receptor subfamily 2 group A member 2)	HNF4G NR2A2	Homo sapiens (Human)	408	FUNCTION: Transcription factor. Has a lower transcription activation potential than HNF4-alpha.		anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Q14542	reviewed	S29A2_HUMAN	Equilibrative nucleoside transporter 2 (hENT2) (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2)	SLC29A2 DER12 ENT2 HNP36	Homo sapiens (Human)	456	FUNCTION: Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:9396714, PubMed:9478986, PubMed:12527552, PubMed:10722669, PubMed:12590919, PubMed:21795683, PubMed:16214850). Functions as a Na(+)-independent, passive transporter (PubMed:9478986). Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine (PubMed:9396714, PubMed:9478986, PubMed:12527552, PubMed:10722669, PubMed:12590919, PubMed:21795683, PubMed:16214850). Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:16214850). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites (PubMed:12527552). Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (PubMed:23639800). Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production (By similarity). {ECO:0000250|UniProtKB:O54699, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:12590919, ECO:0000269|PubMed:16214850, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:9396714, ECO:0000269|PubMed:9478986}.; FUNCTION: [Isoform 3]: Non functional nucleoside transporter protein for adenosine or thymidine tranport. Does not express on cell membrane. {ECO:0000269|PubMed:12527552}.	MISCELLANEOUS: Transport activity is insensitive to nanomolar concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) (PubMed:9396714, PubMed:9478986, PubMed:10722669, PubMed:12590919, PubMed:21795683). Inhibited by higher concentrations of NBMPR (1uM-10uM) (PubMed:9396714, PubMed:9478986, PubMed:10722669, PubMed:12590919). {ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:12590919, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:9396714, ECO:0000269|PubMed:9478986}.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	adenine transport [GO:0015853]; adenosine transport [GO:0032238]; cytidine transport [GO:0015861]; guanine transmembrane transport [GO:1903716]; guanine transport [GO:0015854]; hypoxanthine transport [GO:0035344]; inosine transport [GO:0035340]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; nucleobase transport [GO:0015851]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine-containing compound transmembrane transport [GO:0072531]; thymine transport [GO:0035364]; transport across blood-brain barrier [GO:0150104]; uracil transmembrane transport [GO:1903791]; uridine transport [GO:0015862]; xenobiotic transmembrane transport [GO:0006855]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	adenine transmembrane transporter activity [GO:0015207]; cytidine transmembrane transporter activity [GO:0015212]; guanine transmembrane transporter activity [GO:0015208]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleobase transmembrane transporter activity [GO:0015205]; nucleoside transmembrane transporter activity [GO:0005337]; purine nucleoside transmembrane transporter activity [GO:0015211]; uracil transmembrane transporter activity [GO:0015210]; uridine transmembrane transporter activity [GO:0015213]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; adenine transmembrane transporter activity [GO:0015207]; cytidine transmembrane transporter activity [GO:0015212]; guanine transmembrane transporter activity [GO:0015208]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleobase transmembrane transporter activity [GO:0015205]; nucleoside transmembrane transporter activity [GO:0005337]; purine nucleoside transmembrane transporter activity [GO:0015211]; uracil transmembrane transporter activity [GO:0015210]; uridine transmembrane transporter activity [GO:0015213]; adenine transport [GO:0015853]; adenosine transport [GO:0032238]; cytidine transport [GO:0015861]; guanine transmembrane transport [GO:1903716]; guanine transport [GO:0015854]; hypoxanthine transport [GO:0035344]; inosine transport [GO:0035340]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; nucleobase transport [GO:0015851]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine-containing compound transmembrane transport [GO:0072531]; thymine transport [GO:0035364]; transport across blood-brain barrier [GO:0150104]; uracil transmembrane transport [GO:1903791]; uridine transport [GO:0015862]; xenobiotic transmembrane transport [GO:0006855]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:23639800}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:12527552}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the apical membrane of Sertoli cells. {ECO:0000269|PubMed:23639800}.
Q14554	reviewed	PDIA5_HUMAN	Protein disulfide-isomerase A5 (EC 5.3.4.1) (Protein disulfide isomerase-related protein)	PDIA5 PDIR	Homo sapiens (Human)	519			electron transport chain [GO:0022900]; protein folding [GO:0006457]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]	oxidoreductase activity [GO:0016491]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; oxidoreductase activity [GO:0016491]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; electron transport chain [GO:0022900]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q14558	reviewed	KPRA_HUMAN	Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39)	PRPSAP1	Homo sapiens (Human)	356	FUNCTION: Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.		5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; nucleobase-containing compound metabolic process [GO:0006139]; purine nucleotide biosynthetic process [GO:0006164]	cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189]	ATP binding [GO:0005524]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749]	cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189]; ATP binding [GO:0005524]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; nucleobase-containing compound metabolic process [GO:0006139]; purine nucleotide biosynthetic process [GO:0006164]	
Q14562	reviewed	DHX8_HUMAN	ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1)	DHX8 DDX8	Homo sapiens (Human)	1220	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}.		mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; spliceosomal complex disassembly [GO:0000390]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; spliceosomal complex disassembly [GO:0000390]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28062851, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
Q14563	reviewed	SEM3A_HUMAN	Semaphorin-3A (Semaphorin III) (Sema III)	SEMA3A SEMAD	Homo sapiens (Human)	771	FUNCTION: Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. {ECO:0000269|PubMed:22416012}.		axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonogenesis involved in innervation [GO:0060385]; basal dendrite arborization [GO:0150020]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of neuron projection development [GO:0010977]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron migration [GO:2001224]; regulation of axon extension involved in axon guidance [GO:0048841]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sensory system development [GO:0048880]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]	axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]	chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215]	axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonogenesis involved in innervation [GO:0060385]; basal dendrite arborization [GO:0150020]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of neuron projection development [GO:0010977]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron migration [GO:2001224]; regulation of axon extension involved in axon guidance [GO:0048841]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sensory system development [GO:0048880]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q14565	reviewed	DMC1_HUMAN	Meiotic recombination protein DMC1/LIM15 homolog	DMC1 DMC1H LIM15	Homo sapiens (Human)	340	FUNCTION: Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. {ECO:0000269|PubMed:21307306}.		chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA recombinase assembly [GO:0000730]; double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; male meiosis I [GO:0007141]; meiotic cell cycle [GO:0051321]; mitotic recombination [GO:0006312]; oocyte maturation [GO:0001556]; ovarian follicle development [GO:0001541]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; strand invasion [GO:0042148]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; lateral element [GO:0000800]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; DNA strand exchange activity [GO:0000150]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; lateral element [GO:0000800]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; DNA strand exchange activity [GO:0000150]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA recombinase assembly [GO:0000730]; double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; male meiosis I [GO:0007141]; meiotic cell cycle [GO:0051321]; mitotic recombination [GO:0006312]; oocyte maturation [GO:0001556]; ovarian follicle development [GO:0001541]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; strand invasion [GO:0042148]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61880}. Chromosome {ECO:0000250|UniProtKB:Q61880}.
Q14566	reviewed	MCM6_HUMAN	DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)	MCM6	Homo sapiens (Human)	821	FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:16899510, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.	MISCELLANEOUS: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex. {ECO:0000250|UniProtKB:P97311}.	DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication [GO:1902969]; regulation of DNA-templated DNA replication initiation [GO:0030174]	chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]	chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication [GO:1902969]; regulation of DNA-templated DNA replication initiation [GO:0030174]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16899510}. Chromosome {ECO:0000269|PubMed:16899510}. Note=Binds to chromatin during G1 and detaches from it during S phase. {ECO:0000269|PubMed:16899510}.
Q14568	reviewed	HS902_HUMAN	Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene)	HSP90AA2P HSP90AA2 HSPCAL3	Homo sapiens (Human)	343	FUNCTION: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.		cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of macromolecule metabolic process [GO:0060255]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of primary metabolic process [GO:0080090]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082]; cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of macromolecule metabolic process [GO:0060255]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of primary metabolic process [GO:0080090]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q14571	reviewed	ITPR2_HUMAN	Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)	ITPR2	Homo sapiens (Human)	2701	FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). {ECO:0000250|UniProtKB:Q9Z329}.	MISCELLANEOUS: Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.	cellular response to cAMP [GO:0071320]; cellular response to ethanol [GO:0071361]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]	cell cortex [GO:0005938]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; receptor complex [GO:0043235]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; secretory granule membrane [GO:0030667]	calcium ion binding [GO:0005509]; calcium ion transmembrane transporter activity [GO:0015085]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220]; phosphatidylinositol binding [GO:0035091]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]	cell cortex [GO:0005938]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; receptor complex [GO:0043235]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; secretory granule membrane [GO:0030667]; calcium ion binding [GO:0005509]; calcium ion transmembrane transporter activity [GO:0015085]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220]; phosphatidylinositol binding [GO:0035091]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]; cellular response to cAMP [GO:0071320]; cellular response to ethanol [GO:0071361]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Q14573	reviewed	ITPR3_HUMAN	Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)	ITPR3	Homo sapiens (Human)	2671	FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium (By similarity). Involved in cellular calcium ion homeostasis (PubMed:32949214). {ECO:0000250|UniProtKB:P70227, ECO:0000269|PubMed:32949214}.		calcium ion homeostasis [GO:0055074]; G protein-coupled receptor signaling pathway [GO:0007186]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; release of sequestered calcium ion into cytosol [GO:0051209]; response to calcium ion [GO:0051592]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of taste [GO:0050909]; sensory perception of umami taste [GO:0050917]	apical part of cell [GO:0045177]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nuclear outer membrane [GO:0005640]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; receptor complex [GO:0043235]; sarcoplasmic reticulum [GO:0016529]; secretory granule membrane [GO:0030667]	calcium ion binding [GO:0005509]; calcium-release channel activity [GO:0015278]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220]; inositol hexakisphosphate binding [GO:0000822]; phosphatidylinositol binding [GO:0035091]	apical part of cell [GO:0045177]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nuclear outer membrane [GO:0005640]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; receptor complex [GO:0043235]; sarcoplasmic reticulum [GO:0016529]; secretory granule membrane [GO:0030667]; calcium ion binding [GO:0005509]; calcium-release channel activity [GO:0015278]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220]; inositol hexakisphosphate binding [GO:0000822]; phosphatidylinositol binding [GO:0035091]; calcium ion homeostasis [GO:0055074]; G protein-coupled receptor signaling pathway [GO:0007186]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; release of sequestered calcium ion into cytosol [GO:0051209]; response to calcium ion [GO:0051592]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of taste [GO:0050909]; sensory perception of umami taste [GO:0050917]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Q14574	reviewed	DSC3_HUMAN	Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)	DSC3 CDHF3 DSC4	Homo sapiens (Human)	896	FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.		cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; protein stabilization [GO:0050821]	cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295]	cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Q14584	reviewed	ZN266_HUMAN	Zinc finger protein 266 (Zinc finger protein HZF1)	ZNF266 KIAA2007	Homo sapiens (Human)	549	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q14585	reviewed	ZN345_HUMAN	Zinc finger protein 345 (Zinc finger protein HZF10)	ZNF345	Homo sapiens (Human)	488	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q14587	reviewed	ZN268_HUMAN	Zinc finger protein 268 (Zinc finger protein HZF3)	ZNF268	Homo sapiens (Human)	947	FUNCTION: [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.; FUNCTION: [Isoform 2]: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.		cell differentiation [GO:0030154]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein homodimerization activity [GO:0090073]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein heterodimerization activity [GO:0043497]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell differentiation [GO:0030154]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein homodimerization activity [GO:0090073]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein heterodimerization activity [GO:0043497]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:23665872}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:23665872}. Cytoplasm {ECO:0000269|PubMed:23665872}.
Q14592	reviewed	ZN460_HUMAN	Zinc finger protein 460 (Zinc finger protein 272) (Zinc finger protein HZF8)	ZNF460 ZNF272	Homo sapiens (Human)	562	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q14596	reviewed	NBR1_HUMAN	Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B)	NBR1 1A13B KIAA0049 M17S2 MIG19	Homo sapiens (Human)	966	FUNCTION: Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:33577621, PubMed:24692539). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}.		macroautophagy [GO:0016236]; negative regulation of osteoblast differentiation [GO:0045668]; regulation of bone mineralization [GO:0030500]; regulation of stress-activated MAPK cascade [GO:0032872]	autophagosome [GO:0005776]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; M band [GO:0031430]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; phagophore assembly site [GO:0000407]; receptor complex [GO:0043235]	mitogen-activated protein kinase binding [GO:0051019]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]	autophagosome [GO:0005776]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; M band [GO:0031430]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; phagophore assembly site [GO:0000407]; receptor complex [GO:0043235]; mitogen-activated protein kinase binding [GO:0051019]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]; macroautophagy [GO:0016236]; negative regulation of osteoblast differentiation [GO:0045668]; regulation of bone mineralization [GO:0030500]; regulation of stress-activated MAPK cascade [GO:0032872]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19427866, ECO:0000269|PubMed:35914352}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24879152}. Lysosome {ECO:0000269|PubMed:19250911}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q501R9}. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911). {ECO:0000250|UniProtKB:Q501R9, ECO:0000269|PubMed:19250911}.
Q14623	reviewed	IHH_HUMAN	Indian hedgehog protein (IHH) (EC 3.1.-.-) (HHG-2) [Cleaved into: Indian hedgehog protein N-product]	IHH	Homo sapiens (Human)	411	FUNCTION: [Indian hedgehog protein]: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Plays a role in hedgehog paracrine signaling (PubMed:24342078). Associated with the very-low-density lipoprotein (VLDL) particles to function as a circulating morphogen for endothelial cell integrity maintenance (PubMed:20839884). {ECO:0000250|UniProtKB:Q62226, ECO:0000269|PubMed:20839884, ECO:0000269|PubMed:24342078}.; FUNCTION: [Indian hedgehog protein N-product]: The dually lipidated indian hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton (By similarity). Positively regulates PTHLH expression during endochondral bone formation preventing chondrocyte hypertrophy. In contrast, participates in normal chondrocyte proliferation in a PTHLH-independent pathway (By similarity). {ECO:0000250|UniProtKB:P97812, ECO:0000250|UniProtKB:Q15465, ECO:0000250|UniProtKB:Q62226}.		bone resorption [GO:0045453]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye photoreceptor cell fate commitment [GO:0060220]; cell fate specification [GO:0001708]; cell maturation [GO:0048469]; cell-cell signaling [GO:0007267]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; chondrocyte proliferation [GO:0035988]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic pattern specification [GO:0009880]; embryonic skeletal joint development [GO:0072498]; epithelial cell morphogenesis [GO:0003382]; epithelial cell-cell adhesion [GO:0090136]; head morphogenesis [GO:0060323]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; intein-mediated protein splicing [GO:0016539]; liver regeneration [GO:0097421]; maternal process involved in female pregnancy [GO:0060135]; multicellular organism growth [GO:0035264]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of eye pigmentation [GO:0048074]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of T cell differentiation in thymus [GO:0033085]; neuron development [GO:0048666]; osteoblast differentiation [GO:0001649]; pancreas development [GO:0031016]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoprocessing [GO:0016540]; proteoglycan metabolic process [GO:0006029]; regulation of gene expression [GO:0010468]; regulation of growth [GO:0040008]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; retinal pigment epithelium development [GO:0003406]; self proteolysis [GO:0097264]; skeletal system development [GO:0001501]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; somite development [GO:0061053]; vitelline membrane formation [GO:0030704]	endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; patched binding [GO:0005113]; peptidase activity [GO:0008233]	endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; patched binding [GO:0005113]; peptidase activity [GO:0008233]; bone resorption [GO:0045453]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye photoreceptor cell fate commitment [GO:0060220]; cell fate specification [GO:0001708]; cell maturation [GO:0048469]; cell-cell signaling [GO:0007267]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; chondrocyte proliferation [GO:0035988]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic pattern specification [GO:0009880]; embryonic skeletal joint development [GO:0072498]; epithelial cell morphogenesis [GO:0003382]; epithelial cell-cell adhesion [GO:0090136]; head morphogenesis [GO:0060323]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; intein-mediated protein splicing [GO:0016539]; liver regeneration [GO:0097421]; maternal process involved in female pregnancy [GO:0060135]; multicellular organism growth [GO:0035264]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of eye pigmentation [GO:0048074]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of T cell differentiation in thymus [GO:0033085]; neuron development [GO:0048666]; osteoblast differentiation [GO:0001649]; pancreas development [GO:0031016]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoprocessing [GO:0016540]; proteoglycan metabolic process [GO:0006029]; regulation of gene expression [GO:0010468]; regulation of growth [GO:0040008]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; retinal pigment epithelium development [GO:0003406]; self proteolysis [GO:0097264]; skeletal system development [GO:0001501]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; somite development [GO:0061053]; vitelline membrane formation [GO:0030704]	SUBCELLULAR LOCATION: [Indian hedgehog protein N-product]: Cell membrane {ECO:0000269|PubMed:21537345}; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The N-product remains associated with the cell surface. {ECO:0000250|UniProtKB:Q15465}.; SUBCELLULAR LOCATION: [Indian hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15465}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15465}. Secreted {ECO:0000269|PubMed:24342078}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q15465}.
Q14624	reviewed	ITIH4_HUMAN	Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4]	ITIH4 IHRP ITIHL1 PK120 PRO1851	Homo sapiens (Human)	930	FUNCTION: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. {ECO:0000269|PubMed:19263524}.	MISCELLANEOUS: Possible biomarker for acute ischemic stroke (PubMed:19263524). Peptides derived from the proline-rich potentially active peptide (PRO_0000016542) may be biomarkers for a variety of disease states including breast cancer (PubMed:21137033). {ECO:0000305|PubMed:19263524, ECO:0000305|PubMed:21137033}.	acute-phase response [GO:0006953]; hyaluronan metabolic process [GO:0030212]; response to cytokine [GO:0034097]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; platelet dense granule lumen [GO:0031089]	endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; platelet dense granule lumen [GO:0031089]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; acute-phase response [GO:0006953]; hyaluronan metabolic process [GO:0030212]; response to cytokine [GO:0034097]	SUBCELLULAR LOCATION: Secreted.
Q14626	reviewed	I11RA_HUMAN	Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]	IL11RA	Homo sapiens (Human)	422	FUNCTION: Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. {ECO:0000269|PubMed:21741611, ECO:0000305}.; FUNCTION: [Soluble interleukin-11 receptor subunit alpha]: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:30279168, PubMed:26876177). The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:30279168, PubMed:26876177). {ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:30279168}.; FUNCTION: [Isoform HCR2]: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:30279168, PubMed:26876177). The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:30279168, PubMed:26876177). {ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:30279168}.	MISCELLANEOUS: [Isoform HCR2]: Lacks the entire cytoplasmic domain. {ECO:0000305}.	cytokine-mediated signaling pathway [GO:0019221]; developmental process [GO:0032502]; head development [GO:0060322]; interleukin-11-mediated signaling pathway [GO:0038154]; positive regulation of cell population proliferation [GO:0008284]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	interleukin-11 binding [GO:0019970]; interleukin-11 receptor activity [GO:0004921]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; interleukin-11 binding [GO:0019970]; interleukin-11 receptor activity [GO:0004921]; transmembrane signaling receptor activity [GO:0004888]; cytokine-mediated signaling pathway [GO:0019221]; developmental process [GO:0032502]; head development [GO:0060322]; interleukin-11-mediated signaling pathway [GO:0038154]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: [Interleukin-11 receptor subunit alpha]: Membrane {ECO:0000269|PubMed:26876177}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Soluble interleukin-11 receptor subunit alpha]: Secreted {ECO:0000269|PubMed:26876177}.; SUBCELLULAR LOCATION: [Isoform HCR2]: Secreted {ECO:0000269|PubMed:26876177}.
Q14627	reviewed	I13R2_HUMAN	Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)	IL13RA2 IL13R	Homo sapiens (Human)	380	FUNCTION: Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). {ECO:0000269|PubMed:20223216}.		cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of mast cell degranulation [GO:0043305]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of mast cell degranulation [GO:0043305]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q14642	reviewed	I5P1_HUMAN	Inositol polyphosphate-5-phosphatase A (EC 3.1.3.56) (43 kDa inositol polyphosphate 5-phosphatase) (Type I inositol 1,4,5-trisphosphate 5-phosphatase) (5PTase)	INPP5A 5PTASE	Homo sapiens (Human)	412	FUNCTION: Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8013665, PubMed:8769125, PubMed:8626616). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity). {ECO:0000250|UniProtKB:Q7TNC9, ECO:0000269|PubMed:8013665, ECO:0000269|PubMed:8626616, ECO:0000269|PubMed:8769125}.		inositol phosphate metabolic process [GO:0043647]; inositol phosphate-mediated signaling [GO:0048016]; negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900737]; phosphatidylinositol dephosphorylation [GO:0046856]	dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; PH domain binding [GO:0042731]	dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; PH domain binding [GO:0042731]; inositol phosphate metabolic process [GO:0043647]; inositol phosphate-mediated signaling [GO:0048016]; negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900737]; phosphatidylinositol dephosphorylation [GO:0046856]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8626616, ECO:0000305|PubMed:8006039}; Lipid-anchor {ECO:0000269|PubMed:8626616, ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TNC9}.
Q14643	reviewed	ITPR1_HUMAN	Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)	ITPR1 INSP3R1	Homo sapiens (Human)	2758	FUNCTION: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). {ECO:0000250|UniProtKB:P11881, ECO:0000269|PubMed:27108797}.	MISCELLANEOUS: Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.	calcium ion transport [GO:0006816]; cell morphogenesis [GO:0000902]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial fluid transport [GO:0042045]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of calcium-mediated signaling [GO:0050849]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of insulin secretion [GO:0032024]; post-embryonic development [GO:0009791]; regulation of autophagy [GO:0010506]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; voluntary musculoskeletal movement [GO:0050882]	calcineurin complex [GO:0005955]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; platelet dense tubular network [GO:0031094]; platelet dense tubular network membrane [GO:0031095]; postsynaptic density [GO:0014069]; sarcoplasmic reticulum [GO:0016529]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]	calcium channel inhibitor activity [GO:0019855]; calcium ion binding [GO:0005509]; calcium ion transmembrane transporter activity [GO:0015085]; calcium-release channel activity [GO:0015278]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels [GO:0098695]; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]	calcineurin complex [GO:0005955]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; platelet dense tubular network [GO:0031094]; platelet dense tubular network membrane [GO:0031095]; postsynaptic density [GO:0014069]; sarcoplasmic reticulum [GO:0016529]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]; calcium channel inhibitor activity [GO:0019855]; calcium ion binding [GO:0005509]; calcium ion transmembrane transporter activity [GO:0015085]; calcium-release channel activity [GO:0015278]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels [GO:0098695]; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; calcium ion transport [GO:0006816]; cell morphogenesis [GO:0000902]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial fluid transport [GO:0042045]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of calcium-mediated signaling [GO:0050849]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of insulin secretion [GO:0032024]; post-embryonic development [GO:0009791]; regulation of autophagy [GO:0010506]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; voluntary musculoskeletal movement [GO:0050882]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:27108798}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q9TU34}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27108798}. Note=Endoplasmic reticulum and secretory granules (By similarity). {ECO:0000250|UniProtKB:Q9TU34}.
Q14644	reviewed	RASA3_HUMAN	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein)	RASA3	Homo sapiens (Human)	834	FUNCTION: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.		negative regulation of Ras protein signal transduction [GO:0046580]; signal transduction [GO:0007165]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]	calcium-release channel activity [GO:0015278]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; calcium-release channel activity [GO:0015278]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; negative regulation of Ras protein signal transduction [GO:0046580]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane.
Q14651	reviewed	PLSI_HUMAN	Plastin-1 (Intestine-specific plastin) (I-plastin)	PLS1	Homo sapiens (Human)	629	FUNCTION: Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions. {ECO:0000250|UniProtKB:Q3V0K9}.		actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; auditory receptor cell stereocilium organization [GO:0060088]; intestinal D-glucose absorption [GO:0001951]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of microvillus length [GO:0032532]; terminal web assembly [GO:1902896]; vestibular receptor cell stereocilium organization [GO:0060121]	actin filament [GO:0005884]; actin filament bundle [GO:0032432]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; terminal web [GO:1990357]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; structural constituent of cytoskeleton [GO:0005200]	actin filament [GO:0005884]; actin filament bundle [GO:0032432]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; terminal web [GO:1990357]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; structural constituent of cytoskeleton [GO:0005200]; actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; auditory receptor cell stereocilium organization [GO:0060088]; intestinal D-glucose absorption [GO:0001951]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of microvillus length [GO:0032532]; terminal web assembly [GO:1902896]; vestibular receptor cell stereocilium organization [GO:0060121]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3V0K9}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q3V0K9}.
Q14653	reviewed	IRF3_HUMAN	Interferon regulatory factor 3 (IRF-3)	IRF3	Homo sapiens (Human)	427	FUNCTION: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:24049179, PubMed:31340999). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}.		antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to virus [GO:0098586]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune system process [GO:0002376]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage apoptotic process [GO:0071888]; MDA-5 signaling pathway [GO:0039530]; mRNA transcription [GO:0009299]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; programmed necrotic cell death [GO:0097300]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; regulation of transcription by RNA polymerase II [GO:0006357]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; type I interferon-mediated signaling pathway [GO:0060337]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to virus [GO:0098586]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune system process [GO:0002376]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage apoptotic process [GO:0071888]; MDA-5 signaling pathway [GO:0039530]; mRNA transcription [GO:0009299]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; programmed necrotic cell death [GO:0097300]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; regulation of transcription by RNA polymerase II [GO:0006357]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10805757, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:35922005, ECO:0000305|PubMed:25636800}. Nucleus {ECO:0000269|PubMed:10805757, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:35922005, ECO:0000305|PubMed:25636800}. Mitochondrion {ECO:0000269|PubMed:25609812}. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757, PubMed:35922005). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). {ECO:0000269|PubMed:10805757, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:35922005}.
Q14654	reviewed	KCJ11_HUMAN	ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)	KCNJ11	Homo sapiens (Human)	390	FUNCTION: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. {ECO:0000250, ECO:0000269|PubMed:17855752, ECO:0000269|PubMed:28842488, ECO:0000269|PubMed:9831708}.		action potential [GO:0001508]; apoptotic process [GO:0006915]; CAMKK-AMPK signaling cascade [GO:0061762]; determination of adult lifespan [GO:0008340]; glucose metabolic process [GO:0006006]; inorganic cation transmembrane transport [GO:0098662]; negative regulation of insulin secretion [GO:0046676]; nervous system process [GO:0050877]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of insulin secretion [GO:0050796]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to ATP [GO:0033198]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; response to resveratrol [GO:1904638]; response to xenobiotic stimulus [GO:0009410]; ventricular cardiac muscle tissue development [GO:0003229]	inward rectifying potassium channel [GO:0008282]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]	ankyrin binding [GO:0030506]; ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; potassium ion binding [GO:0030955]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]	inward rectifying potassium channel [GO:0008282]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; ankyrin binding [GO:0030506]; ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; potassium ion binding [GO:0030955]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]; action potential [GO:0001508]; apoptotic process [GO:0006915]; CAMKK-AMPK signaling cascade [GO:0061762]; determination of adult lifespan [GO:0008340]; glucose metabolic process [GO:0006006]; inorganic cation transmembrane transport [GO:0098662]; negative regulation of insulin secretion [GO:0046676]; nervous system process [GO:0050877]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of insulin secretion [GO:0050796]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to ATP [GO:0033198]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; response to resveratrol [GO:1904638]; response to xenobiotic stimulus [GO:0009410]; ventricular cardiac muscle tissue development [GO:0003229]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q14656	reviewed	TM187_HUMAN	Transmembrane protein 187 (Protein ITBA1)	TMEM187 CXorf12 DXS9878E ITBA1	Homo sapiens (Human)	261				membrane [GO:0016020]; transport vesicle [GO:0030133]		membrane [GO:0016020]; transport vesicle [GO:0030133]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q14657	reviewed	LAGE3_HUMAN	EKC/KEOPS complex subunit LAGE3 (L antigen family member 3) (Protein ESO-3) (Protein ITBA2)	LAGE3 DXS9879E ESO3 ITBA2	Homo sapiens (Human)	143	FUNCTION: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). LAGE3 functions as a dimerization module for the complex (PubMed:22912744, PubMed:27903914). {ECO:0000305|PubMed:22912744, ECO:0000305|PubMed:27903914}.		tRNA processing [GO:0008033]; tRNA threonylcarbamoyladenosine metabolic process [GO:0070525]	cytoplasm [GO:0005737]; EKC/KEOPS complex [GO:0000408]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; EKC/KEOPS complex [GO:0000408]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA processing [GO:0008033]; tRNA threonylcarbamoyladenosine metabolic process [GO:0070525]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28805828}. Nucleus {ECO:0000269|PubMed:22912744, ECO:0000269|PubMed:27903914, ECO:0000269|PubMed:28805828}.
Q14667	reviewed	BLTP2_HUMAN	Bridge-like lipid transfer protein family member 2 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) (Protein hobbit homolog)	BLTP2 BCOX1 KIAA0100	Homo sapiens (Human)	2235	FUNCTION: Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution. {ECO:0000250|UniProtKB:Q9VZS7}.			endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	phosphatidylinositol binding [GO:0035091]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; phosphatidylinositol binding [GO:0035091]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9VZS7}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9VZS7}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q06179}. Note=Localizes to endoplasmic reticulum-cell membrane and some endoplasmic reticulum-mitochondria contact sites. {ECO:0000250|UniProtKB:Q9VZS7}.
Q14669	reviewed	TRIPC_HUMAN	E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)	TRIP12 KIAA0045 ULF	Homo sapiens (Human)	1992	FUNCTION: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of embryonic development [GO:0045995]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear thyroid hormone receptor binding [GO:0046966]; ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear thyroid hormone receptor binding [GO:0046966]; ubiquitin protein ligase activity [GO:0061630]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of embryonic development [GO:0045995]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:20208519}.
Q14671	reviewed	PUM1_HUMAN	Pumilio homolog 1 (HsPUM) (Pumilio-1)	PUM1 KIAA0099 PUMH1	Homo sapiens (Human)	1186	FUNCTION: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:21572425, PubMed:18328718, PubMed:21653694, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; adult locomotory behavior [GO:0008344]; miRNA processing [GO:0035196]; mRNA destabilization [GO:0061157]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; post-transcriptional gene silencing [GO:0016441]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell cycle [GO:0051726]; regulation of chromosome segregation [GO:0051983]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of mRNA stability [GO:0043488]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]	miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; adult locomotory behavior [GO:0008344]; miRNA processing [GO:0035196]; mRNA destabilization [GO:0061157]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; post-transcriptional gene silencing [GO:0016441]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell cycle [GO:0051726]; regulation of chromosome segregation [GO:0051983]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of mRNA stability [GO:0043488]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:26724866}. Cytoplasm, P-body {ECO:0000305|PubMed:20818387}. Cytoplasmic granule {ECO:0000269|PubMed:25340845}. Note=Recruited to cytoplasmic stress granules upon viral infection. {ECO:0000269|PubMed:25340845}.
Q14674	reviewed	ESPL1_HUMAN	Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase)	ESPL1 ESP1 KIAA0165	Homo sapiens (Human)	2120	FUNCTION: Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}.		apoptotic process [GO:0006915]; establishment of mitotic spindle localization [GO:0040001]; homologous chromosome segregation [GO:0045143]; meiotic chromosome separation [GO:0051307]; meiotic spindle organization [GO:0000212]; mitotic cytokinesis [GO:0000281]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of sister chromatid cohesion [GO:0045875]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; proteolysis [GO:0006508]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]	catalytic activity [GO:0003824]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; catalytic activity [GO:0003824]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; apoptotic process [GO:0006915]; establishment of mitotic spindle localization [GO:0040001]; homologous chromosome segregation [GO:0045143]; meiotic chromosome separation [GO:0051307]; meiotic spindle organization [GO:0000212]; mitotic cytokinesis [GO:0000281]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of sister chromatid cohesion [GO:0045875]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q14676	reviewed	MDC1_HUMAN	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)	MDC1 KIAA0170 NFBD1	Homo sapiens (Human)	2089	FUNCTION: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652}.		DNA repair [GO:0006281]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]	chromosome [GO:0005694]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		chromosome [GO:0005694]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA repair [GO:0006281]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:20008512}. Chromosome {ECO:0000250}. Note=Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires 'Ser-139' phosphorylation of H2AX. Colocalizes with APTX at sites of DNA double-strand breaks.
Q14677	reviewed	EPN4_HUMAN	Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)	CLINT1 ENTH EPN4 EPNR KIAA0171	Homo sapiens (Human)	625	FUNCTION: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}.		clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897]	clathrin vesicle coat [GO:0030125]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543]	clathrin vesicle coat [GO:0030125]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543]; clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network.
Q14678	reviewed	KANK1_HUMAN	KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein)	KANK1 ANKRD15 KANK KIAA0172	Homo sapiens (Human)	1352	FUNCTION: Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration (PubMed:25961457). Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1 (PubMed:25961457). Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways (PubMed:25961457). {ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:25961457}.		actin cytoskeleton organization [GO:0030036]; cell population proliferation [GO:0008283]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell migration [GO:0030336]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lamellipodium morphogenesis [GO:2000393]; negative regulation of neuron projection development [GO:0010977]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of ruffle assembly [GO:1900028]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; podocyte cell migration [GO:0090521]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of wound healing [GO:0090303]; regulation of establishment of cell polarity [GO:2000114]; regulation of Rho protein signal transduction [GO:0035023]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	beta-catenin binding [GO:0008013]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; beta-catenin binding [GO:0008013]; actin cytoskeleton organization [GO:0030036]; cell population proliferation [GO:0008283]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell migration [GO:0030336]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lamellipodium morphogenesis [GO:2000393]; negative regulation of neuron projection development [GO:0010977]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of ruffle assembly [GO:1900028]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; podocyte cell migration [GO:0090521]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of wound healing [GO:0090303]; regulation of establishment of cell polarity [GO:2000114]; regulation of Rho protein signal transduction [GO:0035023]	SUBCELLULAR LOCATION: Cell projection, ruffle membrane {ECO:0000269|PubMed:19559006}. Cytoplasm {ECO:0000269|PubMed:12133830, ECO:0000269|PubMed:16968744}. Nucleus {ECO:0000269|PubMed:16968744}. Note=Colocalizes with KIF21A in membrane ruffles (PubMed:19559006). Shuttles between the cytoplasm and nucleus (PubMed:16968744). {ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:19559006}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:25961457}. Nucleus {ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:25961457}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000269|PubMed:16968744}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16968744}. Nucleus {ECO:0000269|PubMed:16968744}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000269|PubMed:16968744}.
Q14679	reviewed	TTLL4_HUMAN	Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4)	TTLL4 KIAA0173	Homo sapiens (Human)	1199	FUNCTION: Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. {ECO:0000250|UniProtKB:Q80UG8}.		microtubule cytoskeleton organization [GO:0000226]; peptidyl-glutamic acid modification [GO:0018200]; protein polyglutamylation [GO:0018095]; regulation of blastocyst development [GO:0120222]	9+0 non-motile cilium [GO:0097731]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity [GO:0070739]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	9+0 non-motile cilium [GO:0097731]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity [GO:0070739]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]; microtubule cytoskeleton organization [GO:0000226]; peptidyl-glutamic acid modification [GO:0018200]; protein polyglutamylation [GO:0018095]; regulation of blastocyst development [GO:0120222]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q80UG8}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80UG8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80UG8}. Note=Located in cilia. In some cells, also found in basal bodies. {ECO:0000250|UniProtKB:Q80UG8}.
Q14680	reviewed	MELK_HUMAN	Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)	MELK KIAA0175	Homo sapiens (Human)	651	FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}.	MISCELLANEOUS: Potential therapeutic target for treatment of somatic tumors, such as brain and breast cancers, down-regulation of MELK inhibiting tumorigenesis (PubMed:17960622, PubMed:20861186). {ECO:0000305|PubMed:17960622, ECO:0000305|PubMed:20861186}.	apoptotic process [GO:0006915]; cell population proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; hemopoiesis [GO:0030097]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neural precursor cell proliferation [GO:0061351]; positive regulation of apoptotic process [GO:0043065]; protein autophosphorylation [GO:0046777]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cell population proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; hemopoiesis [GO:0030097]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neural precursor cell proliferation [GO:0061351]; positive regulation of apoptotic process [GO:0043065]; protein autophosphorylation [GO:0046777]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16159311, ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:16159311, ECO:0000269|PubMed:21145462}.
Q14683	reviewed	SMC1A_HUMAN	Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)	SMC1A DXS423E KIAA0178 SB1.8 SMC1 SMC1L1	Homo sapiens (Human)	1233	FUNCTION: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}.	MISCELLANEOUS: Mutated Cornelia de Lange cell lines display genomic instability and sensitivity to ionizing radiation and interstrand cross-linking agents.	cell division [GO:0051301]; DNA repair [GO:0006281]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; response to DNA damage checkpoint signaling [GO:0072423]; response to radiation [GO:0009314]; sister chromatid cohesion [GO:0007062]; somatic stem cell population maintenance [GO:0035019]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; kinetochore [GO:0000776]; meiotic cohesin complex [GO:0030893]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; mediator complex binding [GO:0036033]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; kinetochore [GO:0000776]; meiotic cohesin complex [GO:0030893]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; mediator complex binding [GO:0036033]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; cell division [GO:0051301]; DNA repair [GO:0006281]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; response to DNA damage checkpoint signaling [GO:0072423]; response to radiation [GO:0009314]; sister chromatid cohesion [GO:0007062]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12199140}. Chromosome {ECO:0000269|PubMed:12199140}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12199140}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis.
Q14684	reviewed	RRP1B_HUMAN	Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)	RRP1B KIAA0179	Homo sapiens (Human)	758	FUNCTION: Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}.		apoptotic process [GO:0006915]; cellular response to virus [GO:0098586]; mRNA processing [GO:0006397]; negative regulation of GTPase activity [GO:0034260]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	chromosome [GO:0005694]; cytosol [GO:0005829]; euchromatin [GO:0000791]; granular component [GO:0001652]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]	RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	chromosome [GO:0005694]; cytosol [GO:0005829]; euchromatin [GO:0000791]; granular component [GO:0001652]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; apoptotic process [GO:0006915]; cellular response to virus [GO:0098586]; mRNA processing [GO:0006397]; negative regulation of GTPase activity [GO:0034260]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688, ECO:0000269|PubMed:26311876}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20926688}. Chromosome {ECO:0000269|PubMed:19710015}. Note=Predominantly located in the nucleolus with a small amount found in the nucleoplasm (PubMed:20926688). Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2 (PubMed:20926688). Associates with heterochromatin and euchromatin (PubMed:19710015). {ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20926688}.; SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:26311876}. Note=(Microbial infection) Following infection by influenza A virus, partially translocates from the nucleolus to the nucleoplasm. {ECO:0000269|PubMed:26311876}.
Q14686	reviewed	NCOA6_HUMAN	Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)	NCOA6 AIB3 KIAA0181 RAP250 TRBP	Homo sapiens (Human)	2063	FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.	MISCELLANEOUS: Frequently amplified or overexpressed in colon, breast and lung cancers.	brain development [GO:0007420]; DNA damage response [GO:0006974]; DNA-templated transcription initiation [GO:0006352]; heart development [GO:0007507]; myeloid cell differentiation [GO:0030099]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to hormone [GO:0009725]	cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; intracellular membrane-bounded organelle [GO:0043231]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; intracellular membrane-bounded organelle [GO:0043231]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713]; brain development [GO:0007420]; DNA damage response [GO:0006974]; DNA-templated transcription initiation [GO:0006352]; heart development [GO:0007507]; myeloid cell differentiation [GO:0030099]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to hormone [GO:0009725]	SUBCELLULAR LOCATION: Nucleus.
Q14687	reviewed	GSE1_HUMAN	Genetic suppressor element 1	GSE1 KIAA0182	Homo sapiens (Human)	1217							
Q14689	reviewed	DIP2A_HUMAN	Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1)	DIP2A C21orf106 DIP2 KIAA0184	Homo sapiens (Human)	1571	FUNCTION: Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). {ECO:0000250|UniProtKB:Q8BWT5, ECO:0000269|PubMed:20054002}.		acetyl-CoA biosynthetic process [GO:0006085]; dendritic spine morphogenesis [GO:0060997]; negative regulation of gene expression [GO:0010629]; positive regulation of peptidyl-lysine acetylation [GO:2000758]	cell surface [GO:0009986]; dendritic spine [GO:0043197]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	acetate-CoA ligase activity [GO:0003987]	cell surface [GO:0009986]; dendritic spine [GO:0043197]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; acetate-CoA ligase activity [GO:0003987]; acetyl-CoA biosynthetic process [GO:0006085]; dendritic spine morphogenesis [GO:0060997]; negative regulation of gene expression [GO:0010629]; positive regulation of peptidyl-lysine acetylation [GO:2000758]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20054002}; Peripheral membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250|UniProtKB:Q8BWT5}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q8BWT5}.
Q14690	reviewed	RRP5_HUMAN	Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11)	PDCD11 KIAA0185	Homo sapiens (Human)	1871	FUNCTION: Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}.		rRNA processing [GO:0006364]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]	NF-kappaB binding [GO:0051059]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; NF-kappaB binding [GO:0051059]; RNA binding [GO:0003723]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:14624448, ECO:0000269|PubMed:17654514}.
Q14691	reviewed	PSF1_HUMAN	DNA replication complex GINS protein PSF1 (GINS complex subunit 1)	GINS1 KIAA0186 PSF1	Homo sapiens (Human)	196	FUNCTION: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). {ECO:0000269|PubMed:17417653, ECO:0000269|PubMed:28414293, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}.		DNA strand elongation involved in mitotic DNA replication [GO:1902983]; DNA unwinding involved in DNA replication [GO:0006268]; inner cell mass cell proliferation [GO:0001833]	CMG complex [GO:0071162]; cytoplasm [GO:0005737]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		CMG complex [GO:0071162]; cytoplasm [GO:0005737]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA strand elongation involved in mitotic DNA replication [GO:1902983]; DNA unwinding involved in DNA replication [GO:0006268]; inner cell mass cell proliferation [GO:0001833]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associates with chromatin. {ECO:0000305|PubMed:35585232}.
Q14692	reviewed	BMS1_HUMAN	Ribosome biogenesis protein BMS1 homolog (Ribosome assembly protein BMS1 homolog)	BMS1 BMS1L KIAA0187	Homo sapiens (Human)	1282	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}.		endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]	90S preribosome [GO:0030686]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511]	90S preribosome [GO:0030686]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511]; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
Q14693	reviewed	LPIN1_HUMAN	Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1)	LPIN1 KIAA0188	Homo sapiens (Human)	890	FUNCTION: Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PubMed:20231281, PubMed:29765047). Is involved in adipocyte differentiation (By similarity). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression (By similarity). Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). {ECO:0000250|UniProtKB:Q91ZP3, ECO:0000269|PubMed:20231281, ECO:0000269|PubMed:29765047}.	MISCELLANEOUS: May represent a candidate gene for human lipodysytropy syndromes.	animal organ regeneration [GO:0031100]; cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of myelination [GO:0031642]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidic acid metabolic process [GO:0046473]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA replication [GO:0045740]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432]; triglyceride mobilization [GO:0006642]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713]; animal organ regeneration [GO:0031100]; cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of myelination [GO:0031642]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidic acid metabolic process [GO:0046473]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA replication [GO:0045740]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432]; triglyceride mobilization [GO:0006642]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:29765047}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:29765047}. Nucleus membrane {ECO:0000250|UniProtKB:Q91ZP3}. Note=Translocates from the cytosol to the endoplasmic reticulum following acetylation by KAT5. {ECO:0000269|PubMed:29765047}.
Q14694	reviewed	UBP10_HUMAN	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)	USP10 KIAA0190	Homo sapiens (Human)	798	FUNCTION: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731}.		autophagy [GO:0006914]; cellular response to interleukin-1 [GO:0071347]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of stress granule assembly [GO:0062030]; protein deubiquitination [GO:0016579]; regulation of autophagy [GO:0010506]; rescue of stalled ribosome [GO:0072344]; translesion synthesis [GO:0019985]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; early endosome [GO:0005769]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; molecular function inhibitor activity [GO:0140678]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; early endosome [GO:0005769]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; molecular function inhibitor activity [GO:0140678]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325]; autophagy [GO:0006914]; cellular response to interleukin-1 [GO:0071347]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of stress granule assembly [GO:0062030]; protein deubiquitination [GO:0016579]; regulation of autophagy [GO:0010506]; rescue of stalled ribosome [GO:0072344]; translesion synthesis [GO:0019985]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20096447}. Nucleus {ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:24845384}. Early endosome {ECO:0000269|PubMed:19398555}. Note=Cytoplasmic in normal conditions (PubMed:20096447). After DNA damage, translocates to the nucleus following phosphorylation by ATM (PubMed:20096447). {ECO:0000269|PubMed:20096447}.
Q14696	reviewed	MESD_HUMAN	LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development LRP chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein) (Renal carcinoma antigen NY-REN-61)	MESD KIAA0081 MESDC2 MESDM UNQ1911/PRO4369	Homo sapiens (Human)	234	FUNCTION: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) (PubMed:15014448). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane (PubMed:17488095). Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity). {ECO:0000250|UniProtKB:Q9ERE7, ECO:0000269|PubMed:15014448, ECO:0000269|PubMed:17488095}.		mesoderm development [GO:0007498]; ossification [GO:0001503]; phagocytosis [GO:0006909]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; protein folding [GO:0006457]; protein localization to cell surface [GO:0034394]; Wnt signaling pathway [GO:0016055]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; mesoderm development [GO:0007498]; ossification [GO:0001503]; phagocytosis [GO:0006909]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; protein folding [GO:0006457]; protein localization to cell surface [GO:0034394]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:15014448, ECO:0000269|PubMed:17488095}. Note=Released from apoptotic cells and shed photoreceptor outer segments. {ECO:0000250|UniProtKB:Q9ERE7}.
Q14697	reviewed	GANAB_HUMAN	Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha)	GANAB G2AN KIAA0088	Homo sapiens (Human)	944	FUNCTION: Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	carbohydrate metabolic process [GO:0005975]; N-glycan processing [GO:0006491]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; glucosidase II complex [GO:0017177]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]	alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246]; glucan 1,3-alpha-glucosidase activity [GO:0033919]; RNA binding [GO:0003723]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; glucosidase II complex [GO:0017177]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246]; glucan 1,3-alpha-glucosidase activity [GO:0033919]; RNA binding [GO:0003723]; carbohydrate metabolic process [GO:0005975]; N-glycan processing [GO:0006491]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:33097077, ECO:0000305|PubMed:10929008}. Golgi apparatus {ECO:0000250|UniProtKB:P79403}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.
Q14699	reviewed	RFTN1_HUMAN	Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein)	RFTN1 KIAA0084 MIG2	Homo sapiens (Human)	578	FUNCTION: Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.		B cell receptor signaling pathway [GO:0050853]; dsRNA transport [GO:0033227]; membrane raft assembly [GO:0001765]; positive regulation of growth rate [GO:0040010]; positive regulation of interleukin-17 production [GO:0032740]; protein localization to membrane raft [GO:1903044]; protein transport into membrane raft [GO:0032596]; response to exogenous dsRNA [GO:0043330]; T cell antigen processing and presentation [GO:0002457]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 3 signaling pathway [GO:0034138]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	double-stranded RNA binding [GO:0003725]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; double-stranded RNA binding [GO:0003725]; B cell receptor signaling pathway [GO:0050853]; dsRNA transport [GO:0033227]; membrane raft assembly [GO:0001765]; positive regulation of growth rate [GO:0040010]; positive regulation of interleukin-17 production [GO:0032740]; protein localization to membrane raft [GO:1903044]; protein transport into membrane raft [GO:0032596]; response to exogenous dsRNA [GO:0043330]; T cell antigen processing and presentation [GO:0002457]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 3 signaling pathway [GO:0034138]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}; Lipid-anchor {ECO:0000269|PubMed:12805216}. Cytoplasm {ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. Membrane raft {ECO:0000269|PubMed:12805216}. Endosome {ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. Early endosome {ECO:0000269|PubMed:21266579}. Note=Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3 (PubMed:21266579). Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195). {ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.
Q14703	reviewed	MBTP1_HUMAN	Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Subtilisin/kexin-isozyme 1) (SKI-1)	MBTPS1 KIAA0091 S1P SKI1	Homo sapiens (Human)	1052	FUNCTION: Serine protease that cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4: known substrates include SREBF1/SREBP1, SREBF2/SREBP2, BDNF, GNPTAB, ATF6, ATF6B and FAM20C (PubMed:10644685, PubMed:12782636, PubMed:21719679, PubMed:34349020). Cleaves substrates after Arg-Ser-Val-Leu (SREBP2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu (PubMed:10644685, PubMed:21719679). Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12782636). Also mediates the first step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (PubMed:12782636). Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes (PubMed:21719679). Cleaves the propeptide from FAM20C which is required for FAM20C secretion from the Golgi apparatus membrane and for enhancement of FAM20C kinase activity, promoting osteoblast differentiation and biomineralization (PubMed:34349020). Involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes (PubMed:21719679, PubMed:30046013). It is required for the activation of CREB3L2/BBF2H7, a transcriptional activator of MIA3/TANGO and other genes controlling mega vesicle formation (PubMed:30046013). Therefore, it plays a key role in the regulation of mega vesicle-mediated collagen trafficking (PubMed:30046013). In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the first step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression (PubMed:16417584). {ECO:0000269|PubMed:10644685, ECO:0000269|PubMed:12782636, ECO:0000269|PubMed:16417584, ECO:0000269|PubMed:21719679, ECO:0000269|PubMed:30046013, ECO:0000269|PubMed:34349020}.		ATF6-mediated unfolded protein response [GO:0036500]; cholesterol metabolic process [GO:0008203]; endoplasmic reticulum unfolded protein response [GO:0030968]; lysosome organization [GO:0007040]; membrane protein intracellular domain proteolysis [GO:0031293]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of vesicle-mediated transport [GO:0060627]; response to endoplasmic reticulum stress [GO:0034976]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]	serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; serine-type endopeptidase activity [GO:0004252]; ATF6-mediated unfolded protein response [GO:0036500]; cholesterol metabolic process [GO:0008203]; endoplasmic reticulum unfolded protein response [GO:0030968]; lysosome organization [GO:0007040]; membrane protein intracellular domain proteolysis [GO:0031293]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of vesicle-mediated transport [GO:0060627]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9990022}; Single-pass type I membrane protein {ECO:0000269|PubMed:9990022}. Golgi apparatus membrane {ECO:0000269|PubMed:34349020, ECO:0000269|PubMed:9990022}; Single-pass type I membrane protein {ECO:0000269|PubMed:9990022}. Note=May sort to other organelles, including lysosomal and/or endosomal compartments. {ECO:0000269|PubMed:9990022}.
Q14714	reviewed	SSPN_HUMAN	Sarcospan (K-ras oncogene-associated protein) (Kirsten-ras-associated protein)	SSPN KRAG	Homo sapiens (Human)	243	FUNCTION: Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC.		cell adhesion [GO:0007155]; muscle contraction [GO:0006936]	dystrophin-associated glycoprotein complex [GO:0016010]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; transport vesicle [GO:0030133]		dystrophin-associated glycoprotein complex [GO:0016010]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; transport vesicle [GO:0030133]; cell adhesion [GO:0007155]; muscle contraction [GO:0006936]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions. {ECO:0000250}.
Q14721	reviewed	KCNB1_HUMAN	Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1)	KCNB1	Homo sapiens (Human)	858	FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:8081723, PubMed:1283219, PubMed:10484328, PubMed:12560340, PubMed:19074135, PubMed:19717558, PubMed:24901643). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). {ECO:0000250|UniProtKB:P15387, ECO:0000250|UniProtKB:Q03717, ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:12560340, ECO:0000269|PubMed:1283219, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:19717558, ECO:0000269|PubMed:23161216, ECO:0000269|PubMed:24901643, ECO:0000269|PubMed:8081723}.		action potential [GO:0001508]; cellular response to calcium ion [GO:0071277]; cellular response to glucose stimulus [GO:0071333]; cellular response to nutrient levels [GO:0031669]; clustering of voltage-gated potassium channels [GO:0045163]; glucose homeostasis [GO:0042593]; glutamate receptor signaling pathway [GO:0007215]; negative regulation of insulin secretion [GO:0046676]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of catecholamine secretion [GO:0033605]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of norepinephrine secretion [GO:0010701]; positive regulation of protein targeting to membrane [GO:0090314]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; regulation of action potential [GO:0098900]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of motor neuron apoptotic process [GO:2000671]; response to axon injury [GO:0048678]; response to L-glutamate [GO:1902065]; vesicle docking involved in exocytosis [GO:0006904]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; cell surface [GO:0009986]; cholinergic synapse [GO:0098981]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; lateral plasma membrane [GO:0016328]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; proximal dendrite [GO:1990635]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; protein heterodimerization activity [GO:0046982]; SNARE binding [GO:0000149]; transmembrane transporter binding [GO:0044325]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; cell surface [GO:0009986]; cholinergic synapse [GO:0098981]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; lateral plasma membrane [GO:0016328]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; proximal dendrite [GO:1990635]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; protein heterodimerization activity [GO:0046982]; SNARE binding [GO:0000149]; transmembrane transporter binding [GO:0044325]; action potential [GO:0001508]; cellular response to calcium ion [GO:0071277]; cellular response to glucose stimulus [GO:0071333]; cellular response to nutrient levels [GO:0031669]; clustering of voltage-gated potassium channels [GO:0045163]; glucose homeostasis [GO:0042593]; glutamate receptor signaling pathway [GO:0007215]; negative regulation of insulin secretion [GO:0046676]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of catecholamine secretion [GO:0033605]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of norepinephrine secretion [GO:0010701]; positive regulation of protein targeting to membrane [GO:0090314]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; regulation of action potential [GO:0098900]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of motor neuron apoptotic process [GO:2000671]; response to axon injury [GO:0048678]; response to L-glutamate [GO:1902065]; vesicle docking involved in exocytosis [GO:0006904]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:12560340, ECO:0000269|PubMed:1283219, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:19717558, ECO:0000269|PubMed:24477962, ECO:0000269|PubMed:24901643, ECO:0000269|PubMed:26503721, ECO:0000269|PubMed:8081723}. Perikaryon {ECO:0000269|PubMed:24477962}. Cell projection, axon {ECO:0000269|PubMed:24477962}. Cell projection, dendrite {ECO:0000269|PubMed:24477962}. Membrane; Multi-pass membrane protein. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P15387}. Synapse {ECO:0000250|UniProtKB:P15387}. Synapse, synaptosome {ECO:0000250|UniProtKB:P15387}. Lateral cell membrane {ECO:0000250|UniProtKB:P15387}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P15387}. Note=Localizes to high-density somatodendritic clusters and non-clustered sites on the surface of neocortical and hippocampal pyramidal neurons in a cortical actin cytoskeleton-dependent manner (PubMed:24477962). Localizes also to high-density clusters in the axon initial segment (AIS), at ankyrin-G-deficient sites, on the surface of neocortical and hippocampal pyramidal neurons (PubMed:24477962). KCNB1-containing AIS clusters localize either in close apposition to smooth endoplasmic reticulum cisternal organelles or with GABA-A receptor-containing synapses of hippocampal and cortical pyramidal neurons, respectively (PubMed:24477962). Localizes to high-density clusters on the cell surface of atrial and ventricular myocytes and at the lateral plasma membrane in epithelial cells. Localizes both to the axial and transverse tubules (T tubule) and sarcolemma in ventricular myocytes. Associated with lipid raft domains. In cortical neurons, apoptotic injuries induce de novo plasma membrane insertion in a SNARE-dependent manner causing an apoptotic potassium current surge. {ECO:0000250|UniProtKB:P15387, ECO:0000250|UniProtKB:Q03717, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:24477962, ECO:0000269|PubMed:24901643}.
Q14722	reviewed	KCAB1_HUMAN	Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1)	KCNAB1 KCNA1B	Homo sapiens (Human)	419	FUNCTION: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368, PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity). {ECO:0000250|UniProtKB:P63143, ECO:0000250|UniProtKB:P63144, ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:15361858, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:17540341, ECO:0000269|PubMed:19713757, ECO:0000269|PubMed:7499366, ECO:0000269|PubMed:7603988, ECO:0000269|PubMed:7649300, ECO:0000269|PubMed:7890032, ECO:0000269|PubMed:7890764, ECO:0000269|PubMed:8938711, ECO:0000269|PubMed:9763623, ECO:0000305}.		negative regulation of voltage-gated potassium channel activity [GO:1903817]; potassium ion transport [GO:0006813]; regulation of delayed rectifier potassium channel activity [GO:1902259]; regulation of potassium ion transmembrane transport [GO:1901379]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; juxtaparanode region of axon [GO:0044224]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; voltage-gated potassium channel complex [GO:0008076]	aldo-keto reductase (NADP) activity [GO:0004033]; molecular function inhibitor activity [GO:0140678]; NADPH binding [GO:0070402]; potassium channel regulator activity [GO:0015459]; protein domain specific binding [GO:0019904]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; juxtaparanode region of axon [GO:0044224]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; voltage-gated potassium channel complex [GO:0008076]; aldo-keto reductase (NADP) activity [GO:0004033]; molecular function inhibitor activity [GO:0140678]; NADPH binding [GO:0070402]; potassium channel regulator activity [GO:0015459]; protein domain specific binding [GO:0019904]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; negative regulation of voltage-gated potassium channel activity [GO:1903817]; potassium ion transport [GO:0006813]; regulation of delayed rectifier potassium channel activity [GO:1902259]; regulation of potassium ion transmembrane transport [GO:1901379]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17540341}. Membrane {ECO:0000250|UniProtKB:P63144}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:17540341}; Peripheral membrane protein {ECO:0000269|PubMed:17540341}; Cytoplasmic side {ECO:0000269|PubMed:17540341}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. {ECO:0000269|PubMed:17540341}.
Q14728	reviewed	MFS10_HUMAN	Major facilitator superfamily domain-containing protein 10 (Tetracycline transporter-like protein)	MFSD10 TETRAN	Homo sapiens (Human)	455	FUNCTION: Probable organic anion transporter which may serve as a transporter for some non-steroidal anti-inflammatory drugs (NSAIDs) as well as other organic anions across the luminal membranes of renal proximal tubules at the final excretion step into the urine. {ECO:0000269|PubMed:17362938, ECO:0000269|PubMed:18638446}.		apoptotic process [GO:0006915]; sodium-independent organic anion transport [GO:0043252]	brush border membrane [GO:0031526]; cytoplasmic vesicle membrane [GO:0030659]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]	organic anion transmembrane transporter activity [GO:0008514]; tetracycline transmembrane transporter activity [GO:0008493]	brush border membrane [GO:0031526]; cytoplasmic vesicle membrane [GO:0030659]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; organic anion transmembrane transporter activity [GO:0008514]; tetracycline transmembrane transporter activity [GO:0008493]; apoptotic process [GO:0006915]; sodium-independent organic anion transport [GO:0043252]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:Q9D2V8}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000305|PubMed:18638446}; Multi-pass membrane protein {ECO:0000255}.
Q14738	reviewed	2A5D_HUMAN	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta)	PPP2R5D	Homo sapiens (Human)	602	FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.		negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; nervous system development [GO:0007399]; positive regulation of protein dephosphorylation [GO:0035307]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	phosphoprotein phosphatase activity [GO:0004721]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]; phosphoprotein phosphatase activity [GO:0004721]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; nervous system development [GO:0007399]; positive regulation of protein dephosphorylation [GO:0035307]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.
Q14739	reviewed	LBR_HUMAN	Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase)	LBR	Homo sapiens (Human)	615	FUNCTION: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:9630650, PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}.		cholesterol biosynthetic process [GO:0006695]; neutrophil differentiation [GO:0030223]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]	chromo shadow domain binding [GO:0070087]; delta14-sterol reductase activity [GO:0050613]; DNA binding [GO:0003677]; lamin binding [GO:0005521]; NADPH binding [GO:0070402]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; chromo shadow domain binding [GO:0070087]; delta14-sterol reductase activity [GO:0050613]; DNA binding [GO:0003677]; lamin binding [GO:0005521]; NADPH binding [GO:0070402]; RNA binding [GO:0003723]; cholesterol biosynthetic process [GO:0006695]; neutrophil differentiation [GO:0030223]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:32694168, ECO:0000269|PubMed:8157662}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21327084}. Cytoplasm {ECO:0000269|PubMed:21327084}. Nucleus {ECO:0000269|PubMed:21327084}. Note=Nucleus; nuclear rim. {ECO:0000269|PubMed:21327084}.
Q14746	reviewed	COG2_HUMAN	Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein)	COG2 LDLC	Homo sapiens (Human)	738	FUNCTION: Required for normal Golgi morphology and function.		glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588]	protein-containing complex binding [GO:0044877]	Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588]; protein-containing complex binding [GO:0044877]; glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q14749	reviewed	GNMT_HUMAN	Glycine N-methyltransferase (EC 2.1.1.20)	GNMT	Homo sapiens (Human)	295	FUNCTION: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. {ECO:0000269|PubMed:14651980, ECO:0000269|PubMed:14739680, ECO:0000269|PubMed:17660255, ECO:0000269|PubMed:8281755}.		glycogen metabolic process [GO:0005977]; methionine metabolic process [GO:0006555]; methylation [GO:0032259]; one-carbon metabolic process [GO:0006730]; protein homotetramerization [GO:0051289]; protein modification process [GO:0036211]; regulation of gluconeogenesis [GO:0006111]; S-adenosylhomocysteine metabolic process [GO:0046498]; S-adenosylmethionine metabolic process [GO:0046500]; sarcosine metabolic process [GO:1901052]	cytosol [GO:0005829]	folic acid binding [GO:0005542]; glycine binding [GO:0016594]; glycine N-methyltransferase activity [GO:0017174]; identical protein binding [GO:0042802]; S-adenosyl-L-methionine binding [GO:1904047]	cytosol [GO:0005829]; folic acid binding [GO:0005542]; glycine binding [GO:0016594]; glycine N-methyltransferase activity [GO:0017174]; identical protein binding [GO:0042802]; S-adenosyl-L-methionine binding [GO:1904047]; glycogen metabolic process [GO:0005977]; methionine metabolic process [GO:0006555]; methylation [GO:0032259]; one-carbon metabolic process [GO:0006730]; protein homotetramerization [GO:0051289]; protein modification process [GO:0036211]; regulation of gluconeogenesis [GO:0006111]; S-adenosylhomocysteine metabolic process [GO:0046498]; S-adenosylmethionine metabolic process [GO:0046500]; sarcosine metabolic process [GO:1901052]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P13255}.
Q14764	reviewed	MVP_HUMAN	Major vault protein (MVP) (Lung resistance-related protein)	MVP LRP	Homo sapiens (Human)	893	FUNCTION: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}.		ERBB signaling pathway [GO:0038127]; mRNA transport [GO:0051028]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein tyrosine kinase activity [GO:0061099]; protein transport [GO:0015031]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; ERBB signaling pathway [GO:0038127]; mRNA transport [GO:0051028]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein tyrosine kinase activity [GO:0061099]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16441665}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:16441665}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16441665}. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
Q14765	reviewed	STAT4_HUMAN	Signal transducer and activator of transcription 4	STAT4	Homo sapiens (Human)	748	FUNCTION: Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response (PubMed:8943379, PubMed:10961885). Plays a key role in the differentiation of T-helper 1 cells and the production of interferon-gamma (PubMed:12213961, PubMed:35614130). Participates also in multiple neutrophil functions including chemotaxis and production of the neutrophil extracellular traps (By similarity). After IL12 binding to its receptor IL12RB2, STAT4 interacts with the intracellular domain of IL12RB2 and becomes tyrosine phosphorylated (PubMed:7638186, PubMed:10415122). Phosphorylated STAT4 then homodimerizes and migrates to the nucleus where it can recognize STAT target sequences present in IL12 responsive genes. Although IL12 appears to be the predominant activating signal, STAT4 can also be phosphorylated and activated in response to IFN-gamma stimulation via JAK1 and TYK2 and in response to different interleukins including IL23, IL2 and IL35 (PubMed:11114383, PubMed:34508746). Transcription activation of IFN-gamma gene is mediated by interaction with JUN that forms a complex that efficiently interacts with the AP-1-related sequence of the IFN-gamma promoter (By similarity). In response to IFN-alpha/beta signaling, acts as a transcriptional repressor and suppresses IL5 and IL13 mRNA expression during response to T-cell receptor (TCR) activation (PubMed:26990433). {ECO:0000250|UniProtKB:P42228, ECO:0000269|PubMed:10415122, ECO:0000269|PubMed:10961885, ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12213961, ECO:0000269|PubMed:26990433, ECO:0000269|PubMed:34508746, ECO:0000269|PubMed:35614130, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:8943379}.		cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; interleukin-12-mediated signaling pathway [GO:0035722]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; T-helper 1 cell differentiation [GO:0045063]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; interleukin-12-mediated signaling pathway [GO:0035722]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; T-helper 1 cell differentiation [GO:0045063]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Q14766	reviewed	LTBP1_HUMAN	Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1)	LTBP1	Homo sapiens (Human)	1721	FUNCTION: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}.		regulation of transforming growth factor beta activation [GO:1901388]; sequestering of TGFbeta in extracellular matrix [GO:0035583]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]; protein-containing complex [GO:0032991]	calcium ion binding [GO:0005509]; microfibril binding [GO:0050436]; molecular adaptor activity [GO:0060090]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]; protein-containing complex [GO:0032991]; calcium ion binding [GO:0005509]; microfibril binding [GO:0050436]; molecular adaptor activity [GO:0060090]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; regulation of transforming growth factor beta activation [GO:1901388]; sequestering of TGFbeta in extracellular matrix [GO:0035583]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16157329}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:16157329, ECO:0000269|PubMed:8617200}.
Q14767	reviewed	LTBP2_HUMAN	Latent-transforming growth factor beta-binding protein 2 (LTBP-2)	LTBP2 C14orf141 LTBP3	Homo sapiens (Human)	1821	FUNCTION: May play an integral structural role in elastic-fiber architectural organization and/or assembly. {ECO:0000303|PubMed:10743502, ECO:0000303|PubMed:11104663}.		protein secretion [GO:0009306]; protein targeting [GO:0006605]; supramolecular fiber organization [GO:0097435]; transforming growth factor beta receptor signaling pathway [GO:0007179]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; microfibril binding [GO:0050436]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; microfibril binding [GO:0050436]; protein secretion [GO:0009306]; protein targeting [GO:0006605]; supramolecular fiber organization [GO:0097435]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:7798248}.
Q14773	reviewed	ICAM4_HUMAN	Intercellular adhesion molecule 4 (ICAM-4) (Landsteiner-Wiener blood group glycoprotein) (LW blood group protein) (CD antigen CD242)	ICAM4 LW	Homo sapiens (Human)	271	FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins. {ECO:0000269|PubMed:11435317}.		cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]	SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Short]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9ERM2}; Single-pass type I membrane protein {ECO:0000255}.
Q14774	reviewed	HLX_HUMAN	H2.0-like homeobox protein (Homeobox protein HB24) (Homeobox protein HLX1)	HLX HLX1	Homo sapiens (Human)	488	FUNCTION: Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity). {ECO:0000250}.		embryonic digestive tract morphogenesis [GO:0048557]; enteric nervous system development [GO:0048484]; epithelial cell proliferation [GO:0050673]; liver development [GO:0001889]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; organ growth [GO:0035265]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of organ growth [GO:0046622]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519]; T-helper 1 cell differentiation [GO:0045063]; T-helper 2 cell differentiation [GO:0045064]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; embryonic digestive tract morphogenesis [GO:0048557]; enteric nervous system development [GO:0048484]; epithelial cell proliferation [GO:0050673]; liver development [GO:0001889]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; organ growth [GO:0035265]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of organ growth [GO:0046622]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519]; T-helper 1 cell differentiation [GO:0045063]; T-helper 2 cell differentiation [GO:0045064]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q14781	reviewed	CBX2_HUMAN	Chromobox protein homolog 2	CBX2	Homo sapiens (Human)	532	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). {ECO:0000250|UniProtKB:P30658, ECO:0000269|PubMed:19361780, ECO:0000269|PubMed:21282530}.	MISCELLANEOUS: The human orthologuous proteins of Drosophila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different complexes.	cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; development of primary sexual characteristics [GO:0045137]; negative regulation of transcription by RNA polymerase II [GO:0000122]	euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; methylated histone binding [GO:0035064]	euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; methylated histone binding [GO:0035064]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; development of primary sexual characteristics [GO:0045137]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. Chromosome {ECO:0000269|PubMed:18927235}. Note=Localized in distinct foci on chromatin and in chromocenters. Localizes to the inactive X chromosome. Seems to be recruited to H3K27me3, H3K9ac and H3K3me2 sites on chromatin. {ECO:0000269|PubMed:18927235}.
Q14789	reviewed	GOGB1_HUMAN	Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin)	GOLGB1	Homo sapiens (Human)	3259	FUNCTION: May participate in forming intercisternal cross-bridges of the Golgi complex.	MISCELLANEOUS: Antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.	Golgi organization [GO:0007030]; protein localization to pericentriolar material [GO:1905793]; regulation of DNA-templated transcription [GO:0006355]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]	RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; Golgi organization [GO:0007030]; protein localization to pericentriolar material [GO:1905793]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type I membrane protein.
Q14790	reviewed	CASP8_HUMAN	Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]	CASP8 MCH5	Homo sapiens (Human)	479	FUNCTION: Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed:8681376, PubMed:8681377, PubMed:9006941, PubMed:9184224, PubMed:8962078, PubMed:35446120, PubMed:35338844). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death (PubMed:23516580, PubMed:8681376, PubMed:8681377, PubMed:9006941, PubMed:9184224, PubMed:8962078, PubMed:35446120, PubMed:35338844). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:8962078, PubMed:9006941, PubMed:16916640). Binding to the adapter molecule FADD recruits it to either receptor TNFRSF6/FAS mediated or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:32929201, PubMed:34012073). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 and PARP2 (PubMed:8681376). {ECO:0000250|UniProtKB:O89110, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:8681376, ECO:0000269|PubMed:8681377, ECO:0000269|PubMed:8755496, ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9006941, ECO:0000269|PubMed:9184224}.; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). {ECO:0000269|PubMed:12010809, ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.	MISCELLANEOUS: [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	activation of cysteine-type endopeptidase activity [GO:0097202]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; B cell activation [GO:0042113]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic cyclic compound [GO:0071407]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; heart development [GO:0007507]; macrophage differentiation [GO:0030225]; natural killer cell activation [GO:0030101]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of necroptotic process [GO:0060546]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of proteolysis [GO:0045862]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; pyroptosis [GO:0070269]; regulation of cytokine production [GO:0001817]; regulation of innate immune response [GO:0045088]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; self proteolysis [GO:0097264]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell activation [GO:0042110]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ripoptosome [GO:0097342]	cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; cysteine-type peptidase activity [GO:0008234]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]	CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ripoptosome [GO:0097342]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; cysteine-type peptidase activity [GO:0008234]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; activation of cysteine-type endopeptidase activity [GO:0097202]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; B cell activation [GO:0042113]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic cyclic compound [GO:0071407]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; heart development [GO:0007507]; macrophage differentiation [GO:0030225]; natural killer cell activation [GO:0030101]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of necroptotic process [GO:0060546]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of proteolysis [GO:0045862]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; pyroptosis [GO:0070269]; regulation of cytokine production [GO:0001817]; regulation of innate immune response [GO:0045088]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; self proteolysis [GO:0097264]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell activation [GO:0042110]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9JHX4}. Nucleus {ECO:0000250|UniProtKB:Q9JHX4}.
Q147X3	reviewed	NAA30_HUMAN	N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit)	NAA30 C14orf35 MAK3 NAT12	Homo sapiens (Human)	362	FUNCTION: Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate. {ECO:0000269|PubMed:19398576}.		N-terminal peptidyl-methionine acetylation [GO:0017196]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatC complex [GO:0031417]; nucleus [GO:0005634]	peptide alpha-N-acetyltransferase activity [GO:0004596]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatC complex [GO:0031417]; nucleus [GO:0005634]; peptide alpha-N-acetyltransferase activity [GO:0004596]; N-terminal peptidyl-methionine acetylation [GO:0017196]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:25732826}. Nucleus {ECO:0000269|PubMed:25732826}.
Q14802	reviewed	FXYD3_HUMAN	FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3)	FXYD3 MAT8 PLML	Homo sapiens (Human)	87	FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447). {ECO:0000269|PubMed:17077088, ECO:0000269|PubMed:21454534, ECO:0000269|PubMed:7836447}.; FUNCTION: [Isoform 1]: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.; FUNCTION: [Isoform 2]: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.	MISCELLANEOUS: Marker of a cell type preferentially transformed by neu or ras oncoprotein.	chloride transport [GO:0006821]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transport [GO:0043269]; sodium ion transport [GO:0006814]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	ATPase binding [GO:0051117]; chloride channel activity [GO:0005254]; sodium channel regulator activity [GO:0017080]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; ATPase binding [GO:0051117]; chloride channel activity [GO:0005254]; sodium channel regulator activity [GO:0017080]; chloride transport [GO:0006821]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transport [GO:0043269]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
Q14807	reviewed	KIF22_HUMAN	Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4)	KIF22 KID KNSL4	Homo sapiens (Human)	665	FUNCTION: Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}.		DNA repair [GO:0006281]; metaphase chromosome alignment [GO:0051310]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; sister chromatid cohesion [GO:0007062]	chromatin [GO:0000785]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	chromatin [GO:0000785]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; DNA repair [GO:0006281]; metaphase chromosome alignment [GO:0051310]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; sister chromatid cohesion [GO:0007062]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8599929}. Cytoplasm, cytoskeleton {ECO:0000305}.
Q14814	reviewed	MEF2D_HUMAN	Myocyte-specific enhancer factor 2D	MEF2D	Homo sapiens (Human)	521	FUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}.		adult heart development [GO:0007512]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; osteoblast differentiation [GO:0001649]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; skeletal muscle cell differentiation [GO:0035914]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; adult heart development [GO:0007512]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; osteoblast differentiation [GO:0001649]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823}. Note=Translocated by HDAC4 to nuclear dots.
Q14831	reviewed	GRM7_HUMAN	Metabotropic glutamate receptor 7 (mGluR7)	GRM7 GPRC1G MGLUR7	Homo sapiens (Human)	915	FUNCTION: G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (PubMed:9473604). {ECO:0000269|PubMed:33500274, ECO:0000269|PubMed:9473604}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; axon development [GO:0061564]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; glycosylation [GO:0070085]; negative regulation of glutamate secretion [GO:0014050]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of sound [GO:0007605]	asymmetric synapse [GO:0032279]; axon [GO:0030424]; cell cortex [GO:0005938]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; receptor complex [GO:0043235]	adenylate cyclase inhibitor activity [GO:0010855]; calcium ion binding [GO:0005509]; glutamate binding [GO:0016595]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]; PDZ domain binding [GO:0030165]; protein dimerization activity [GO:0046983]; serine binding [GO:0070905]	asymmetric synapse [GO:0032279]; axon [GO:0030424]; cell cortex [GO:0005938]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; receptor complex [GO:0043235]; adenylate cyclase inhibitor activity [GO:0010855]; calcium ion binding [GO:0005509]; glutamate binding [GO:0016595]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]; PDZ domain binding [GO:0030165]; protein dimerization activity [GO:0046983]; serine binding [GO:0070905]; adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; axon development [GO:0061564]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; glycosylation [GO:0070085]; negative regulation of glutamate secretion [GO:0014050]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33500274}; Multi-pass membrane protein {ECO:0000255}.
Q14832	reviewed	GRM3_HUMAN	Metabotropic glutamate receptor 3 (mGluR3)	GRM3 GPRC1C MGLUR3	Homo sapiens (Human)	879	FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:8840013}.	MISCELLANEOUS: [Isoform 2]: Appears to be membrane-associated, despite the absence of the seven-transmembrane domain. {ECO:0000305}.	chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; negative regulation of adenylate cyclase activity [GO:0007194]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of synaptic transmission, glutamatergic [GO:0051966]	astrocyte projection [GO:0097449]; axon [GO:0030424]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	calcium channel regulator activity [GO:0005246]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110]	astrocyte projection [GO:0097449]; axon [GO:0030424]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; calcium channel regulator activity [GO:0005246]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; negative regulation of adenylate cyclase activity [GO:0007194]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of synaptic transmission, glutamatergic [GO:0051966]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8840013}; Multi-pass membrane protein {ECO:0000269|PubMed:8840013}.
Q14833	reviewed	GRM4_HUMAN	Metabotropic glutamate receptor 4 (mGluR4)	GRM4 GPRC1D MGLUR4	Homo sapiens (Human)	912	FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:7617140, ECO:0000269|PubMed:8738157, ECO:0000269|PubMed:9473604}.		adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; neurotransmitter secretion [GO:0007269]; positive regulation of MAPK cascade [GO:0043410]; regulation of neuron apoptotic process [GO:0043523]; regulation of synaptic transmission, glutamatergic [GO:0051966]	cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]	cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; neurotransmitter secretion [GO:0007269]; positive regulation of MAPK cascade [GO:0043410]; regulation of neuron apoptotic process [GO:0043523]; regulation of synaptic transmission, glutamatergic [GO:0051966]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7617140, ECO:0000269|PubMed:8738157}; Multi-pass membrane protein {ECO:0000269|PubMed:7617140, ECO:0000269|PubMed:8738157}.
Q14839	reviewed	CHD4_HUMAN	Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)	CHD4	Homo sapiens (Human)	1912	FUNCTION: ATP-dependent helicase that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:17626165, PubMed:9804427, PubMed:16428440, PubMed:28977666). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}.	MISCELLANEOUS: One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.	chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; regulation of synapse assembly [GO:0051963]; terminal button organization [GO:0072553]	centrosome [GO:0005813]; cerebellar granule cell to Purkinje cell synapse [GO:0150048]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; site of DNA damage [GO:0090734]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cerebellar granule cell to Purkinje cell synapse [GO:0150048]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; site of DNA damage [GO:0090734]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]; chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; regulation of synapse assembly [GO:0051963]; terminal button organization [GO:0072553]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27616479, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17626165}. Note=Associates with centrosomes in interphase (By similarity). Localizes to sites of DNA damage in a manner dependent on ZMYND8 and ZNF687 (PubMed:28977666, PubMed:27732854). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28977666}.
Q14847	reviewed	LASP1_HUMAN	LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)	LASP1 MLN50	Homo sapiens (Human)	261	FUNCTION: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}.		monoatomic ion transport [GO:0006811]	cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; monoatomic ion transmembrane transporter activity [GO:0015075]	cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; monoatomic ion transmembrane transporter activity [GO:0015075]; monoatomic ion transport [GO:0006811]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with the F-actin rich cortical cytoskeleton. {ECO:0000250}.
Q14849	reviewed	STAR3_HUMAN	StAR-related lipid transfer protein 3 (Metastatic lymph node gene 64 protein) (MLN 64) (Protein CAB1) (START domain-containing protein 3) (StARD3)	STARD3 CAB1 MLN64	Homo sapiens (Human)	445	FUNCTION: Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464, PubMed:33124732). The sterol transport mechanism is triggered by phosphorylation of FFAT motif that leads to membrane tethering between the endoplasmic reticulum and late endosomes via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464, PubMed:33124732). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544). {ECO:0000269|PubMed:11053434, ECO:0000269|PubMed:12070139, ECO:0000269|PubMed:15930133, ECO:0000269|PubMed:19965586, ECO:0000269|PubMed:21322544, ECO:0000269|PubMed:22514632, ECO:0000269|PubMed:24105263, ECO:0000269|PubMed:28377464, ECO:0000269|PubMed:33124732}.		cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; lipid metabolic process [GO:0006629]; mitochondrial transport [GO:0006839]; progesterone biosynthetic process [GO:0006701]; steroid metabolic process [GO:0008202]; vesicle tethering to endoplasmic reticulum [GO:0099044]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; organelle membrane contact site [GO:0044232]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; organelle membrane contact site [GO:0044232]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; protein homodimerization activity [GO:0042803]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; lipid metabolic process [GO:0006629]; mitochondrial transport [GO:0006839]; progesterone biosynthetic process [GO:0006701]; steroid metabolic process [GO:0008202]; vesicle tethering to endoplasmic reticulum [GO:0099044]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:11053434, ECO:0000269|PubMed:16709157, ECO:0000269|PubMed:24105263, ECO:0000269|PubMed:28377464, ECO:0000269|PubMed:29858488}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA, VAPB or MOSPD2. {ECO:0000269|PubMed:24105263, ECO:0000269|PubMed:29858488}.
Q14863	reviewed	PO6F1_HUMAN	POU domain, class 6, transcription factor 1 (Brain-specific homeobox/POU domain protein 5) (Brain-5) (Brn-5) (mPOU homeobox protein)	POU6F1 BRN5 MPOU TCFB1	Homo sapiens (Human)	301	FUNCTION: Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3'). {ECO:0000250}.		brain development [GO:0007420]; heart development [GO:0007507]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; brain development [GO:0007420]; heart development [GO:0007507]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q14865	reviewed	ARI5B_HUMAN	AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2)	ARID5B DESRT MRF2	Homo sapiens (Human)	1188	FUNCTION: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269|PubMed:21532585}.		adipose tissue development [GO:0060612]; adrenal gland development [GO:0030325]; cell development [GO:0048468]; cellular response to leukemia inhibitory factor [GO:1990830]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; female gonad development [GO:0008585]; fibroblast migration [GO:0010761]; kidney development [GO:0001822]; liver development [GO:0001889]; male gonad development [GO:0008584]; multicellular organism growth [GO:0035264]; muscle organ morphogenesis [GO:0048644]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nitrogen compound metabolic process [GO:0006807]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; adipose tissue development [GO:0060612]; adrenal gland development [GO:0030325]; cell development [GO:0048468]; cellular response to leukemia inhibitory factor [GO:1990830]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; female gonad development [GO:0008585]; fibroblast migration [GO:0010761]; kidney development [GO:0001822]; liver development [GO:0001889]; male gonad development [GO:0008584]; multicellular organism growth [GO:0035264]; muscle organ morphogenesis [GO:0048644]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nitrogen compound metabolic process [GO:0006807]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
Q14872	reviewed	MTF1_HUMAN	Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1)	MTF1	Homo sapiens (Human)	753	FUNCTION: Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity). {ECO:0000250|UniProtKB:Q07243, ECO:0000269|PubMed:8065932}.		cartilage homeostasis [GO:1990079]; cellular response to zinc ion [GO:0071294]; central nervous system development [GO:0007417]; DNA-templated transcription [GO:0006351]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cadmium ion [GO:0046686]; response to metal ion [GO:0010038]; response to oxidative stress [GO:0006979]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; histone acetyltransferase binding [GO:0035035]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; histone acetyltransferase binding [GO:0035035]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cartilage homeostasis [GO:1990079]; cellular response to zinc ion [GO:0071294]; central nervous system development [GO:0007417]; DNA-templated transcription [GO:0006351]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cadmium ion [GO:0046686]; response to metal ion [GO:0010038]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8065932}. Cytoplasm {ECO:0000250|UniProtKB:Q07243}. Note=Translocation to the nucleus is induced by metals. {ECO:0000250|UniProtKB:Q07243}.
Q14894	reviewed	CRYM_HUMAN	Ketimine reductase mu-crystallin (EC 1.5.1.25) (NADP-regulated thyroid-hormone-binding protein)	CRYM THBP	Homo sapiens (Human)	314	FUNCTION: Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. {ECO:0000269|PubMed:21332720}.		lysine catabolic process [GO:0006554]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sensory perception of sound [GO:0007605]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]	NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; thiomorpholine-carboxylate dehydrogenase activity [GO:0047127]; thyroid hormone binding [GO:0070324]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; thiomorpholine-carboxylate dehydrogenase activity [GO:0047127]; thyroid hormone binding [GO:0070324]; transcription corepressor activity [GO:0003714]; lysine catabolic process [GO:0006554]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sensory perception of sound [GO:0007605]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327]	SUBCELLULAR LOCATION: Cytoplasm.
Q14896	reviewed	MYPC3_HUMAN	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)	MYBPC3	Homo sapiens (Human)	1274	FUNCTION: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.		cardiac muscle contraction [GO:0060048]; cell adhesion [GO:0007155]; heart morphogenesis [GO:0003007]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of muscle filament sliding [GO:0032971]; regulation of striated muscle contraction [GO:0006942]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	A band [GO:0031672]; C zone [GO:0014705]; cardiac myofibril [GO:0097512]; cytosol [GO:0005829]; sarcomere [GO:0030017]; striated muscle myosin thick filament [GO:0005863]	actin binding [GO:0003779]; ATPase activator activity [GO:0001671]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; myosin heavy chain binding [GO:0032036]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]	A band [GO:0031672]; C zone [GO:0014705]; cardiac myofibril [GO:0097512]; cytosol [GO:0005829]; sarcomere [GO:0030017]; striated muscle myosin thick filament [GO:0005863]; actin binding [GO:0003779]; ATPase activator activity [GO:0001671]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; myosin heavy chain binding [GO:0032036]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]; cardiac muscle contraction [GO:0060048]; cell adhesion [GO:0007155]; heart morphogenesis [GO:0003007]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of muscle filament sliding [GO:0032971]; regulation of striated muscle contraction [GO:0006942]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	
Q14914	reviewed	PTGR1_HUMAN	Prostaglandin reductase 1 (PRG-1) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (Dithiolethione-inducible gene 1 protein) (D3T-inducible gene 1 protein) (DIG-1) (Leukotriene B4 12-hydroxydehydrogenase) (NAD(P)H-dependent alkenal/one oxidoreductase) (EC 1.3.1.74)	PTGR1 LTB4DH	Homo sapiens (Human)	329	FUNCTION: NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (PubMed:25619643) (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). {ECO:0000250|UniProtKB:P97584, ECO:0000250|UniProtKB:Q29073, ECO:0000269|PubMed:25619643}.		leukotriene B4 metabolic process [GO:0036102]; leukotriene metabolic process [GO:0006691]; lipoxin A4 metabolic process [GO:2001302]; prostaglandin metabolic process [GO:0006693]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	13-lipoxin reductase activity [GO:0036185]; 13-prostaglandin reductase activity [GO:0036132]; 15-oxoprostaglandin 13-oxidase activity [GO:0047522]; 2-alkenal reductase (NADP+) activity [GO:0035798]; leukotriene B4 12-hydroxy dehydrogenase activity [GO:0097257]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; 13-lipoxin reductase activity [GO:0036185]; 13-prostaglandin reductase activity [GO:0036132]; 15-oxoprostaglandin 13-oxidase activity [GO:0047522]; 2-alkenal reductase (NADP+) activity [GO:0035798]; leukotriene B4 12-hydroxy dehydrogenase activity [GO:0097257]; leukotriene B4 metabolic process [GO:0036102]; leukotriene metabolic process [GO:0006691]; lipoxin A4 metabolic process [GO:2001302]; prostaglandin metabolic process [GO:0006693]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q29073}.
Q14916	reviewed	NPT1_HUMAN	Sodium-dependent phosphate transport protein 1 (Na(+)/PI cotransporter 1) (Na/Pi-4) (Renal Na(+)-dependent phosphate cotransporter 1) (Renal sodium-dependent phosphate transport protein 1) (Renal sodium-phosphate transport protein 1) (Sodium/phosphate cotransporter 1) (Solute carrier family 17 member 1)	SLC17A1 NPT1	Homo sapiens (Human)	467	FUNCTION: Important for the resorption of phosphate by the kidney (PubMed:7826357). May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:7826357). Plays a role in urate transport in the kidney (PubMed:27906618, PubMed:25252215). {ECO:0000269|PubMed:25252215, ECO:0000269|PubMed:27906618, ECO:0000269|PubMed:7826357}.		monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; phosphate ion transport [GO:0006817]; sodium-dependent phosphate transport [GO:0044341]; urate metabolic process [GO:0046415]; urate transport [GO:0015747]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]	phosphate ion transmembrane transporter activity [GO:0015114]; sodium:phosphate symporter activity [GO:0005436]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]; phosphate ion transmembrane transporter activity [GO:0015114]; sodium:phosphate symporter activity [GO:0005436]; transmembrane transporter activity [GO:0022857]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; phosphate ion transport [GO:0006817]; sodium-dependent phosphate transport [GO:0044341]; urate metabolic process [GO:0046415]; urate transport [GO:0015747]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:25252215, ECO:0000269|PubMed:27906618}; Multi-pass membrane protein {ECO:0000255}.
Q14919	reviewed	NC2A_HUMAN	Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha)	DRAP1	Homo sapiens (Human)	205	FUNCTION: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; transcription by RNA polymerase II [GO:0006366]	negative cofactor 2 complex [GO:0017054]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	core promoter sequence-specific DNA binding [GO:0001046]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; TBP-class protein binding [GO:0017025]	negative cofactor 2 complex [GO:0017054]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; core promoter sequence-specific DNA binding [GO:0001046]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; TBP-class protein binding [GO:0017025]; negative regulation of transcription by RNA polymerase II [GO:0000122]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q14929	reviewed	ZN169_HUMAN	Zinc finger protein 169	ZNF169	Homo sapiens (Human)	603	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q14934	reviewed	NFAC4_HUMAN	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3)	NFATC4 NFAT3	Homo sapiens (Human)	902	FUNCTION: Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:7749981, PubMed:11514544, PubMed:11997522, PubMed:17875713, PubMed:17213202, PubMed:18668201, PubMed:25663301). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:7749981, PubMed:18668201, PubMed:18347059). Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}.	MISCELLANEOUS: [Isoform 3]: Due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 10]: Due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 12]: Due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 13]: Due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 18]: Due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 20]: Due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 23]: Due to an intron retention. {ECO:0000305}.	brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; branching involved in blood vessel morphogenesis [GO:0001569]; calcineurin-NFAT signaling cascade [GO:0033173]; cellular respiration [GO:0045333]; cellular response to lithium ion [GO:0071285]; cellular response to UV [GO:0034644]; dendrite morphogenesis [GO:0048813]; heart development [GO:0007507]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synapse maturation [GO:2000297]; negative regulation of Wnt signaling pathway [GO:0030178]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of transcription by RNA polymerase II [GO:0006357]; synapse maturation [GO:0060074]; transcription by RNA polymerase II [GO:0006366]; vascular associated smooth muscle cell development [GO:0097084]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; peroxisome proliferator activated receptor binding [GO:0042975]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; peroxisome proliferator activated receptor binding [GO:0042975]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; branching involved in blood vessel morphogenesis [GO:0001569]; calcineurin-NFAT signaling cascade [GO:0033173]; cellular respiration [GO:0045333]; cellular response to lithium ion [GO:0071285]; cellular response to UV [GO:0034644]; dendrite morphogenesis [GO:0048813]; heart development [GO:0007507]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synapse maturation [GO:2000297]; negative regulation of Wnt signaling pathway [GO:0030178]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of transcription by RNA polymerase II [GO:0006357]; synapse maturation [GO:0060074]; transcription by RNA polymerase II [GO:0006366]; vascular associated smooth muscle cell development [GO:0097084]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201}. Nucleus {ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:12370307, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:18691762}. Note=When hyperphosphorylated, localizes in the cytosol. When intracellular Ca(2+) levels increase, dephosphorylation by calcineurin/PPP3CA leads to translocation into the nucleus (PubMed:11997522, PubMed:18347059). MAPK7/ERK5 and MTOR regulate NFATC4 nuclear export through phosphorylation at Ser-168 and Ser-170 (PubMed:18347059). {ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:18347059}.
Q14938	reviewed	NFIX_HUMAN	Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein)	NFIX	Homo sapiens (Human)	502	FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.		DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
Q14940	reviewed	SL9A5_HUMAN	Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5)	SLC9A5 NHE5	Homo sapiens (Human)	896	FUNCTION: Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues (PubMed:9933641, PubMed:10692428, PubMed:19276089, PubMed:24936055). Acts as a negative regulator of dendritic spine growth (PubMed:21551074). Plays a role in postsynaptic remodeling and signaling (PubMed:24006492, PubMed:21551074). Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking (PubMed:24936055). {ECO:0000269|PubMed:10692428, ECO:0000269|PubMed:19276089, ECO:0000269|PubMed:21551074, ECO:0000269|PubMed:24006492, ECO:0000269|PubMed:24936055, ECO:0000269|PubMed:9933641}.		monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]	dendritic spine membrane [GO:0032591]; focal adhesion [GO:0005925]; membrane [GO:0016020]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202]	arrestin family protein binding [GO:1990763]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	dendritic spine membrane [GO:0032591]; focal adhesion [GO:0005925]; membrane [GO:0016020]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202]; arrestin family protein binding [GO:1990763]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12205089, ECO:0000269|PubMed:15699339, ECO:0000269|PubMed:19276089, ECO:0000269|PubMed:21296876, ECO:0000269|PubMed:21551074, ECO:0000269|PubMed:24936055}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:12205089, ECO:0000269|PubMed:21296876}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendritic spine membrane {ECO:0000269|PubMed:21551074}; Multi-pass membrane protein {ECO:0000255}. Synaptic cell membrane {ECO:0000269|PubMed:21551074}; Multi-pass membrane protein. Cell junction, focal adhesion {ECO:0000269|PubMed:24006492}. Note=Cycles between recycling endosome and plasma membrane in response to diverse stimuli. Its internalization is clathrin- and beta-arrestin dependent and its plasma membrane insertion from the recycling endosomes requires phosphoinositide 3-kinase (PIK3CA) and SCAMP2. {ECO:0000269|PubMed:12205089, ECO:0000269|PubMed:15699339, ECO:0000269|PubMed:19276089, ECO:0000269|PubMed:21296876}.
Q14943	reviewed	KI3S1_HUMAN	Killer cell immunoglobulin-like receptor 3DS1 (Natural killer-associated transcript 10) (NKAT-10)	KIR3DS1 NKAT10	Homo sapiens (Human)	382	FUNCTION: Receptor on natural killer (NK) cells for MHC class I molecules. Upon interaction with peptide-free HLA-F open conformer, triggers NK cell degranulation and anti-viral cytokine production. {ECO:0000269|PubMed:27455421}.		immune response [GO:0006955]; natural killer cell activation [GO:0030101]	plasma membrane [GO:0005886]	MHC class I receptor activity [GO:0032393]	plasma membrane [GO:0005886]; MHC class I receptor activity [GO:0032393]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q14953	reviewed	KI2S5_HUMAN	Killer cell immunoglobulin-like receptor 2DS5 (CD158 antigen-like family member G) (Natural killer-associated transcript 9) (NKAT-9) (CD antigen CD158g)	KIR2DS5 CD158G NKAT9	Homo sapiens (Human)	304	FUNCTION: Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity (PubMed:28685972, PubMed:18624290, PubMed:18682925). Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 represented in this entry (PubMed:28685972). {ECO:0000269|PubMed:18624290, ECO:0000269|PubMed:18682925, ECO:0000269|PubMed:24269691, ECO:0000269|PubMed:28685972}.		immune response [GO:0006955]	membrane [GO:0016020]; plasma membrane [GO:0005886]	HLA-C specific inhibitory MHC class I receptor activity [GO:0030110]	membrane [GO:0016020]; plasma membrane [GO:0005886]; HLA-C specific inhibitory MHC class I receptor activity [GO:0030110]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18624290, ECO:0000269|PubMed:18682925, ECO:0000269|PubMed:24269691}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000269|PubMed:18682925, ECO:0000269|PubMed:24269691}.
Q14954	reviewed	KI2S1_HUMAN	Killer cell immunoglobulin-like receptor 2DS1 (CD158 antigen-like family member H) (MHC class I NK cell receptor Eb6 ActI) (CD antigen CD158h)	KIR2DS1 CD158H	Homo sapiens (Human)	304	FUNCTION: Receptor on natural killer (NK) cells for some HLA-C alleles such as w6. Does not inhibit the activity of NK cells. {ECO:0000269|PubMed:9430221}.		immune response [GO:0006955]	membrane [GO:0016020]; plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18682925, ECO:0000269|PubMed:23715743, ECO:0000269|PubMed:9430221}; Single-pass type I membrane protein {ECO:0000255}.
Q14956	reviewed	GPNMB_HUMAN	Transmembrane glycoprotein NMB (Hematopoietic growth factor inducible neurokinin-1 type)	GPNMB HGFIN NMB UNQ1725/PRO9925	Homo sapiens (Human)	572	FUNCTION: Could be a melanogenic enzyme. {ECO:0000250}.		cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytokine production [GO:0001818]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of tumor necrosis factor production [GO:0032720]; positive chemotaxis [GO:0050918]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein phosphorylation [GO:0001934]; regulation of angiogenesis [GO:0045765]; regulation of tissue remodeling [GO:0034103]; signal transduction [GO:0007165]	early endosome membrane [GO:0031901]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886]	chemoattractant activity [GO:0042056]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; receptor ligand activity [GO:0048018]; syndecan binding [GO:0045545]	early endosome membrane [GO:0031901]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886]; chemoattractant activity [GO:0042056]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; receptor ligand activity [GO:0048018]; syndecan binding [GO:0045545]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytokine production [GO:0001818]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of tumor necrosis factor production [GO:0032720]; positive chemotaxis [GO:0050918]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein phosphorylation [GO:0001934]; regulation of angiogenesis [GO:0045765]; regulation of tissue remodeling [GO:0034103]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:16489096, ECO:0000269|PubMed:16609006}. Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:29336782}; Single-pass type I membrane protein {ECO:0000305}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.
Q14957	reviewed	NMDE3_HUMAN	Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)	GRIN2C NMDAR2C	Homo sapiens (Human)	1233	FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). {ECO:0000250|UniProtKB:Q01098, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:28095420, ECO:0000305}.		brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; directional locomotion [GO:0033058]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term synaptic potentiation [GO:0060291]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of protein catabolic process [GO:0042177]; neuromuscular process controlling balance [GO:0050885]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein localization to postsynaptic membrane [GO:1903539]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to wounding [GO:0009611]; synaptic transmission, glutamatergic [GO:0035249]	endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]	glutamate-gated calcium ion channel activity [GO:0022849]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; glutamate-gated calcium ion channel activity [GO:0022849]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; directional locomotion [GO:0033058]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term synaptic potentiation [GO:0060291]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of protein catabolic process [GO:0042177]; neuromuscular process controlling balance [GO:0050885]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein localization to postsynaptic membrane [GO:1903539]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to wounding [GO:0009611]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26875626}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane; Multi-pass membrane protein.
Q14964	reviewed	RB39A_HUMAN	Ras-related protein Rab-39A (Rab-39)	RAB39A RAB39	Homo sapiens (Human)	217	FUNCTION: Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K (PubMed:24349490). May be involved in multiple neurite formation (By similarity). {ECO:0000250|UniProtKB:Q8BHD0, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:24349490}.		autophagy [GO:0006914]; phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagy [GO:0006914]; phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:24349490}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome {ECO:0000269|PubMed:24349490}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
Q14966	reviewed	ZN638_HUMAN	Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein)	ZNF638 NP220 ZFML	Homo sapiens (Human)	1978	FUNCTION: Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:8647861, PubMed:30487602). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}.	MISCELLANEOUS: [Isoform 5]: Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients. {ECO:0000305|PubMed:11149944}.; MISCELLANEOUS: [Isoform 5]: Broadly expressed. {ECO:0000305}.	regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	double-stranded DNA binding [GO:0003690]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; double-stranded DNA binding [GO:0003690]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000255|PROSITE-ProRule:PRU00130, ECO:0000269|PubMed:11813260, ECO:0000269|PubMed:8647861}.
Q14973	reviewed	NTCP_HUMAN	Hepatic sodium/bile acid cotransporter (Cell growth-inhibiting gene 29 protein) (Na(+)/bile acid cotransporter) (Na(+)/taurocholate transport protein) (Sodium/taurocholate cotransporting polypeptide) (NTCP) (Solute carrier family 10 member 1) (SLC10A1)	SLC10A1 NTCP GIG29	Homo sapiens (Human)	349	FUNCTION: As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:8132774, PubMed:14660639, PubMed:24867799, PubMed:34060352). It is strictly dependent on the extracellular presence of sodium (PubMed:8132774, PubMed:14660639, PubMed:24867799, PubMed:34060352). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, PubMed:34060352). Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321). {ECO:0000269|PubMed:14660639, ECO:0000269|PubMed:24867799, ECO:0000269|PubMed:34060352, ECO:0000269|PubMed:8132774, ECO:0000303|PubMed:33222321}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis B virus. {ECO:0000269|PubMed:23150796}.		bile acid and bile salt transport [GO:0015721]; bile acid signaling pathway [GO:0038183]; cellular response to xenobiotic stimulus [GO:0071466]; regulation of bile acid secretion [GO:0120188]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	bile acid:sodium symporter activity [GO:0008508]; virus receptor activity [GO:0001618]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; bile acid:sodium symporter activity [GO:0008508]; virus receptor activity [GO:0001618]; bile acid and bile salt transport [GO:0015721]; bile acid signaling pathway [GO:0038183]; cellular response to xenobiotic stimulus [GO:0071466]; regulation of bile acid secretion [GO:0120188]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14660639, ECO:0000269|PubMed:24867799}; Multi-pass membrane protein.
Q14974	reviewed	IMB1_HUMAN	Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97)	KPNB1 NTF97	Homo sapiens (Human)	876	FUNCTION: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In association with IPO7, mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus. {ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:9687515}.		astral microtubule organization [GO:0030953]; establishment of mitotic spindle localization [GO:0040001]; establishment of protein localization [GO:0045184]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606]; Ran protein signal transduction [GO:0031291]; ribosomal protein import into nucleus [GO:0006610]; RNA import into nucleus [GO:0006404]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]	enzyme binding [GO:0019899]; Hsp90 protein binding [GO:0051879]; importin-alpha family protein binding [GO:0061676]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]; enzyme binding [GO:0019899]; Hsp90 protein binding [GO:0051879]; importin-alpha family protein binding [GO:0061676]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]; astral microtubule organization [GO:0030953]; establishment of mitotic spindle localization [GO:0040001]; establishment of protein localization [GO:0045184]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606]; Ran protein signal transduction [GO:0031291]; ribosomal protein import into nucleus [GO:0006610]; RNA import into nucleus [GO:0006404]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11891849}. Nucleus envelope {ECO:0000269|PubMed:11891849}.
Q14978	reviewed	NOLC1_HUMAN	Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)	NOLC1 KIAA0035 NS5ATP13	Homo sapiens (Human)	699	FUNCTION: Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}.		mitotic cell cycle [GO:0000278]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; nucleolus organization [GO:0007000]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; molecular function inhibitor activity [GO:0140678]; protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; molecular function inhibitor activity [GO:0140678]; protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; mitotic cell cycle [GO:0000278]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; nucleolus organization [GO:0007000]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:7657714}. Cytoplasm {ECO:0000269|PubMed:7657714}. Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase. {ECO:0000269|PubMed:7657714}.
Q14980	reviewed	NUMA1_HUMAN	Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)	NUMA1 NMP22 NUMA	Homo sapiens (Human)	2115	FUNCTION: Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.	MISCELLANEOUS: Also known as nuclear matrix protein-22/NMP-22/NMP22, an antigen used in diagnostic tests of bladder cancer. {ECO:0000269|PubMed:9730450}.	anastral spindle assembly [GO:0055048]; astral microtubule organization [GO:0030953]; cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; meiotic cell cycle [GO:0051321]; microtubule bundle formation [GO:0001578]; nucleus organization [GO:0006997]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; positive regulation of hair follicle development [GO:0051798]; positive regulation of intracellular transport [GO:0032388]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of mitotic spindle elongation [GO:1902846]; positive regulation of protein localization to cell cortex [GO:1904778]; positive regulation of protein localization to spindle pole body [GO:1902365]; positive regulation of spindle assembly [GO:1905832]; regulation of metaphase plate congression [GO:0090235]; regulation of mitotic spindle organization [GO:0060236]	cell cortex [GO:0005938]; cell cortex region [GO:0099738]; centrosome [GO:0005813]; chromosome [GO:0005694]; cortical microtubule [GO:0055028]; cytoplasmic microtubule bundle [GO:1905720]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; lateral cell cortex [GO:0097575]; lateral plasma membrane [GO:0016328]; microtubule bundle [GO:0097427]; microtubule minus-end [GO:0036449]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; spindle pole centrosome [GO:0031616]	disordered domain specific binding [GO:0097718]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; microtubule minus-end binding [GO:0051011]; microtubule plus-end binding [GO:0051010]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]; tubulin binding [GO:0015631]	cell cortex [GO:0005938]; cell cortex region [GO:0099738]; centrosome [GO:0005813]; chromosome [GO:0005694]; cortical microtubule [GO:0055028]; cytoplasmic microtubule bundle [GO:1905720]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; lateral cell cortex [GO:0097575]; lateral plasma membrane [GO:0016328]; microtubule bundle [GO:0097427]; microtubule minus-end [GO:0036449]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; spindle pole centrosome [GO:0031616]; disordered domain specific binding [GO:0097718]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; microtubule minus-end binding [GO:0051011]; microtubule plus-end binding [GO:0051010]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]; tubulin binding [GO:0015631]; anastral spindle assembly [GO:0055048]; astral microtubule organization [GO:0030953]; cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; meiotic cell cycle [GO:0051321]; microtubule bundle formation [GO:0001578]; nucleus organization [GO:0006997]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; positive regulation of hair follicle development [GO:0051798]; positive regulation of intracellular transport [GO:0032388]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of mitotic spindle elongation [GO:1902846]; positive regulation of protein localization to cell cortex [GO:1904778]; positive regulation of protein localization to spindle pole body [GO:1902365]; positive regulation of spindle assembly [GO:1905832]; regulation of metaphase plate congression [GO:0090235]; regulation of mitotic spindle organization [GO:0060236]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1541630, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:27462074}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10811826}. Nucleus matrix {ECO:0000269|PubMed:10075938, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:1541636, ECO:0000269|PubMed:7962183}. Chromosome {ECO:0000269|PubMed:1541630}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:26765568}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10811826, ECO:0000269|PubMed:1541630, ECO:0000269|PubMed:1541636, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26562023, ECO:0000269|PubMed:26765568}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:10811826, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:1541630, ECO:0000269|PubMed:1541636, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:26562023, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000269|PubMed:7962183}. Cytoplasm, cell cortex {ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24996901}. Cell membrane {ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901}; Lipid-anchor {ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901}; Cytoplasmic side {ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901}. Lateral cell membrane {ECO:0000250|UniProtKB:E9Q7G0}. Note=Mitotic cell cycle-dependent shuttling protein that relocalizes from the interphase nucleus to the spindle poles and cell cortex (PubMed:1541636, PubMed:10811826). The localization to the spindle poles is regulated by AAAS (PubMed:26246606). In interphase, resides in the nuclear matrix (PubMed:1541630, PubMed:1541636, PubMed:23921553). In prophase, restricted to the interchromatin or condensed chromosome space (PubMed:10811826). In prometaphase, after nuclear envelope disassembly, forms aggregates both in the spindle midzone and at duplicated centrosomes and astral microtubules (MTs) of the bipolar spindle apparatus (PubMed:10811826). Translocates from the spindle midzone towards the spindle poles along spindle fibers in a MT- and dynein-dynactin-dependent manner until the anaphase onset (PubMed:1541636, PubMed:10811826). In metaphase, recruited to the polar cortical region in a GPSM2- and GNAI1-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901). Excluded from the metaphase equatorial cortical region in a RanGTP-dependent manner (PubMed:22327364, PubMed:23870127). Phosphorylation on Thr-2055 by CDK1 results in its localization at spindle poles in metaphase, but not at the cell cortex (PubMed:23921553). In anaphase, recruited and anchored at the cell membrane of the polar cortical region in a EPB41-, EPB41L2-, phosphatidylinositol-dependent and GPSM2- and G(i) alpha proteins-independent manner (PubMed:23870127, PubMed:24996901, PubMed:24109598, PubMed:24371089). Excluded from the anaphase equatorial region of the cell cortex in a RACGAP1- and KIF23-dependent and RanGTP-independent manner (PubMed:24996901). Associated with astral MTs emanating from the spindle poles during anaphase (PubMed:12445386, PubMed:24996901). Nonphosphorylated Thr-2055 localizes at the cell cortex, weakly during metaphase and more prominently during anaphase in a phosphatase PPP2CA-dependent manner (PubMed:23921553). As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident (PubMed:1541636). Localizes to the tips of cortical MTs in prometaphase (PubMed:26765568). Localizes along MTs and specifically to both MT plus and minus ends (PubMed:26765568). Accumulates also at MT tips near the cell periphery (PubMed:26765568). Colocalizes with GPSM2 at mitotic spindle poles during mitosis (PubMed:11781568, PubMed:21816348). Colocalizes with SPAG5 at mitotic spindle at prometaphase and at mitotic spindle poles at metaphase and anaphase (PubMed:27462074). Colocalizes with ABRO1 at mitotic spindle poles (PubMed:26195665). Colocalized with TNKS from prophase through to anaphase in mitosis (PubMed:16076287). Colocalizes with tubulin alpha (PubMed:12445386). CCSAP is essential for its centrosomal localization (PubMed:26562023). In horizontally retinal progenitor dividing cells, localized to the lateral cortical region (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:10811826, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:1541630, ECO:0000269|PubMed:1541636, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:26562023, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol {ECO:0000269|PubMed:7962183}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:7962183}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:7962183}. Note=During interphase, mainly clustered at the centrosomal region in the cytosol. After entry into mitosis, detected at mitotic spindle poles. {ECO:0000269|PubMed:7962183}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm, cytosol {ECO:0000269|PubMed:7962183}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:7962183}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:7962183}. Note=During interphase, mainly clustered at the centrosomal region in the cytosol. After entry into mitosis, detected at mitotic spindle poles. {ECO:0000269|PubMed:7962183}.
Q14982	reviewed	OPCM_HUMAN	Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1)	OPCML IGLON1 OBCAM	Homo sapiens (Human)	345	FUNCTION: Binds opioids in the presence of acidic lipids; probably involved in cell contact.		cell adhesion [GO:0007155]; neuron recognition [GO:0008038]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell adhesion [GO:0007155]; neuron recognition [GO:0008038]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Q14990	reviewed	ODFP1_HUMAN	Outer dense fiber protein 1 (Heat shock protein beta-10) (HspB10)	ODF1 HSPB10 ODFP	Homo sapiens (Human)	250	FUNCTION: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]; outer dense fiber [GO:0001520]		nucleus [GO:0005634]; outer dense fiber [GO:0001520]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	
Q14993	reviewed	COJA1_HUMAN	Collagen alpha-1(XIX) chain (Collagen alpha-1(Y) chain)	COL19A1	Homo sapiens (Human)	1142	FUNCTION: May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. {ECO:0000269|PubMed:12788917}.		cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cell-cell adhesion [GO:0098609]; extracellular matrix organization [GO:0030198]; skeletal muscle tissue development [GO:0007519]; skeletal system development [GO:0001501]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cell-cell adhesion [GO:0098609]; extracellular matrix organization [GO:0030198]; skeletal muscle tissue development [GO:0007519]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q14994	reviewed	NR1I3_HUMAN	Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67)	NR1I3 CAR	Homo sapiens (Human)	352	FUNCTION: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.		cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7. {ECO:0000250}.
Q14995	reviewed	NR1D2_HUMAN	Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R)	NR1D2	Homo sapiens (Human)	579	FUNCTION: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle (By similarity). Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (By similarity). Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (By similarity). May play a role in the circadian control of neutrophilic inflammation in the lung (By similarity). {ECO:0000250|UniProtKB:Q60674, ECO:0000269|PubMed:17892483, ECO:0000269|PubMed:17996965}.		cell differentiation [GO:0030154]; circadian behavior [GO:0048512]; energy homeostasis [GO:0097009]; hormone-mediated signaling pathway [GO:0009755]; lipid homeostasis [GO:0055088]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of inflammatory response [GO:0050727]; regulation of lipid metabolic process [GO:0019216]; regulation of skeletal muscle cell differentiation [GO:2001014]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; circadian behavior [GO:0048512]; energy homeostasis [GO:0097009]; hormone-mediated signaling pathway [GO:0009755]; lipid homeostasis [GO:0055088]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of inflammatory response [GO:0050727]; regulation of lipid metabolic process [GO:0019216]; regulation of skeletal muscle cell differentiation [GO:2001014]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:17892483, ECO:0000269|PubMed:17996965}. Cytoplasm {ECO:0000250|UniProtKB:Q60674}. Note=Phosphorylation by CSNK1E enhances its cytoplasmic localization. {ECO:0000250|UniProtKB:Q60674}.
Q14997	reviewed	PSME4_HUMAN	Proteasome activator complex subunit 4 (Proteasome activator PA200)	PSME4 KIAA0077	Homo sapiens (Human)	1843	FUNCTION: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. {ECO:0000269|PubMed:12093752, ECO:0000269|PubMed:18845680, ECO:0000269|PubMed:22550082, ECO:0000269|PubMed:23706739}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; sperm DNA condensation [GO:0035092]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spermatoproteasome complex [GO:1990111]	lysine-acetylated histone binding [GO:0070577]; peptidase activator activity [GO:0016504]; proteasome binding [GO:0070628]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spermatoproteasome complex [GO:1990111]; lysine-acetylated histone binding [GO:0070577]; peptidase activator activity [GO:0016504]; proteasome binding [GO:0070628]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; sperm DNA condensation [GO:0035092]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000269|PubMed:12093752}. Nucleus speckle {ECO:0000250}. Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2).
Q14999	reviewed	CUL7_HUMAN	Cullin-7 (CUL-7)	CUL7 KIAA0076	Homo sapiens (Human)	1698	FUNCTION: Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions. {ECO:0000269|PubMed:16547496, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:20139075, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}.		epithelial to mesenchymal transition [GO:0001837]; Golgi organization [GO:0007030]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; placenta development [GO:0001890]; positive regulation of dendrite morphogenesis [GO:0050775]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of mitotic nuclear division [GO:0007088]; ubiquitin-dependent protein catabolic process [GO:0006511]; vasculogenesis [GO:0001570]	3M complex [GO:1990393]; anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]	ubiquitin protein ligase binding [GO:0031625]	3M complex [GO:1990393]; anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; ubiquitin protein ligase binding [GO:0031625]; epithelial to mesenchymal transition [GO:0001837]; Golgi organization [GO:0007030]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; placenta development [GO:0001890]; positive regulation of dendrite morphogenesis [GO:0050775]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of mitotic nuclear division [GO:0007088]; ubiquitin-dependent protein catabolic process [GO:0006511]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with FBXW8 at the Golgi apparatus in neurons; localization to Golgi is mediated by OBSL1. During mitosis, localizes to the mitotic apparatus (PubMed:24793695). CCDC8 is required for centrosomal location (PubMed:24793695). {ECO:0000269|PubMed:24793695}.
Q149M9	reviewed	NWD1_HUMAN	NACHT domain- and WD repeat-containing protein 1	NWD1	Homo sapiens (Human)	1564	FUNCTION: May play a role in the control of androgen receptor (AR) protein steady-state levels. {ECO:0000269|PubMed:24681825}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of gene expression [GO:0010628]	cytosol [GO:0005829]; nucleolus [GO:0005730]	ATP binding [GO:0005524]	cytosol [GO:0005829]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of gene expression [GO:0010628]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24681825}.
Q149N8	reviewed	SHPRH_HUMAN	E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)	SHPRH KIAA2023	Homo sapiens (Human)	1683	FUNCTION: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289, ECO:0000269|PubMed:18719106}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; nucleosome assembly [GO:0006334]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]	nucleoplasm [GO:0005654]; nucleosome [GO:0000786]	ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; nucleosome assembly [GO:0006334]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]	
Q14BN4	reviewed	SLMAP_HUMAN	Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein)	SLMAP KIAA1601 SLAP UNQ1847/PRO3577	Homo sapiens (Human)	828	FUNCTION: May play a role during myoblast fusion. {ECO:0000250}.	MISCELLANEOUS: [Isoform 3]: Incomplete sequence. {ECO:0000305}.	muscle contraction [GO:0006936]; protein localization to plasma membrane [GO:0072659]; regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900825]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of voltage-gated sodium channel activity [GO:1905150]	microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; smooth endoplasmic reticulum [GO:0005790]		microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; smooth endoplasmic reticulum [GO:0005790]; muscle contraction [GO:0006936]; protein localization to plasma membrane [GO:0072659]; regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900825]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of voltage-gated sodium channel activity [GO:1905150]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum. Detected along the Z- and M-lines in cardiomyocytes. Centrosome. Localizes to the centrosomes in a microtubule- dependent manner (By similarity). {ECO:0000250}.
Q14C86	reviewed	GAPD1_HUMAN	GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)	GAPVD1 GAPEX5 KIAA1521 RAP6	Homo sapiens (Human)	1478	FUNCTION: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269|PubMed:16410077}.		endocytosis [GO:0006897]; regulation of protein transport [GO:0051223]	cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; endocytosis [GO:0006897]; regulation of protein transport [GO:0051223]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:16410077}; Peripheral membrane protein {ECO:0000269|PubMed:16410077}. Endosome {ECO:0000269|PubMed:16410077}. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.
Q14CB8	reviewed	RHG19_HUMAN	Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19)	ARHGAP19	Homo sapiens (Human)	494	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.		regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17454002}.
Q14CM0	reviewed	FRPD4_HUMAN	FERM and PDZ domain-containing protein 4 (PDZ domain-containing protein 10) (PSD-95-interacting regulator of spine morphogenesis) (Preso)	FRMPD4 KIAA0316 PDZD10 PDZK10	Homo sapiens (Human)	1322	FUNCTION: Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:19118189}.		positive regulation of synapse structural plasticity [GO:0051835]	cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; protein-containing complex [GO:0032991]	phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; protein-containing complex [GO:0032991]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; positive regulation of synapse structural plasticity [GO:0051835]	SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000269|PubMed:19118189}.
Q14CN2	reviewed	CLCA4_HUMAN	Calcium-activated chloride channel regulator 4 (EC 3.4.-.-) (Calcium-activated chloride channel family member 4) (hCLCA4) (Calcium-activated chloride channel protein 2) (CaCC-2) (hCaCC-2) (Chloride channel accessory 4) [Cleaved into: Calcium-activated chloride channel regulator 4, 110 kDa form; Calcium-activated chloride channel regulator 4, 30 kDa form]	CLCA4 CaCC2 UNQ562/PRO1124	Homo sapiens (Human)	919	FUNCTION: May be involved in mediating calcium-activated chloride conductance.		monoatomic ion transmembrane transport [GO:0034220]; proteolysis [GO:0006508]	apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; monoatomic ion transmembrane transport [GO:0034220]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Apical cell membrane {ECO:0000250}. Secreted {ECO:0000250}. Note=The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. {ECO:0000250}.
Q14CN4	reviewed	K2C72_HUMAN	Keratin, type II cytoskeletal 72 (Cytokeratin-72) (CK-72) (Keratin-72) (K72) (Type II inner root sheath-specific keratin-K6irs2) (Type-II keratin Kb35)	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	Homo sapiens (Human)	511	FUNCTION: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
Q14CS0	reviewed	UBX2B_HUMAN	UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37)	UBXN2B	Homo sapiens (Human)	331	FUNCTION: Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000269|PubMed:17141156, ECO:0000269|PubMed:23649807}.		autophagosome assembly [GO:0000045]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of protein localization to centrosome [GO:1904780]; nuclear membrane reassembly [GO:0031468]; positive regulation of mitotic centrosome separation [GO:0046604]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616]	ubiquitin binding [GO:0043130]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616]; ubiquitin binding [GO:0043130]; autophagosome assembly [GO:0000045]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of protein localization to centrosome [GO:1904780]; nuclear membrane reassembly [GO:0031468]; positive regulation of mitotic centrosome separation [GO:0046604]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0C627}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P0C627}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P0C627}. Golgi apparatus {ECO:0000250|UniProtKB:P0C627}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q0KL01}. Note=Localizes to centrosome during mitotic prophase and metaphase. {ECO:0000250|UniProtKB:Q0KL01}.
Q14CW9	reviewed	AT7L3_HUMAN	Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog)	ATXN7L3	Homo sapiens (Human)	347	FUNCTION: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583). {ECO:0000255|HAMAP-Rule:MF_03047, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:21746879, ECO:0000269|PubMed:27601583}.		chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	DUBm complex [GO:0071819]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]	nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]	DUBm complex [GO:0071819]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]; nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03047, ECO:0000269|PubMed:27601583}.
Q14CX7	reviewed	NAA25_HUMAN	N-alpha-acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25) (p120)	NAA25 C12orf30 MDM20 NAP1	Homo sapiens (Human)	972	FUNCTION: Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. May play a role in normal cell-cycle progression. {ECO:0000269|PubMed:18570629}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; NatB complex [GO:0031416]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; NatB complex [GO:0031416]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18570629}.
Q14CZ0	reviewed	HAPR1_HUMAN	HUWE1-associated protein modifying stress responses 1 (Telomere attrition and p53 response 1 protein)	HAPSTR1 C16orf72 TAPR1	Homo sapiens (Human)	275	FUNCTION: Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs (PubMed:35776542). Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage (PubMed:33660365). May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 (PubMed:33660365). {ECO:0000269|PubMed:33660365, ECO:0000269|PubMed:35776542}.		negative regulation of signal transduction by p53 class mediator [GO:1901797]; regulation of cellular response to stress [GO:0080135]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin protein ligase binding [GO:0031625]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; regulation of cellular response to stress [GO:0080135]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35776542}. Cytoplasm {ECO:0000269|PubMed:35776542}.
Q14CZ7	reviewed	FAKD3_HUMAN	FAST kinase domain-containing protein 3, mitochondrial	FASTKD3	Homo sapiens (Human)	662	FUNCTION: Required for normal mitochondrial respiration (PubMed:20869947). Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity (PubMed:27789713). {ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:27789713}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial RNA processing [GO:0000963]; positive regulation of mitochondrial translation [GO:0070131]; regulation of mitochondrial mRNA stability [GO:0044528]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein granule [GO:0035770]	RNA binding [GO:0003723]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein granule [GO:0035770]; RNA binding [GO:0003723]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial RNA processing [GO:0000963]; positive regulation of mitochondrial translation [GO:0070131]; regulation of mitochondrial mRNA stability [GO:0044528]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:27789713}.
Q14CZ8	reviewed	HECAM_HUMAN	Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM)	HEPACAM	Homo sapiens (Human)	416	FUNCTION: Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation. {ECO:0000269|PubMed:15885354, ECO:0000269|PubMed:15917256}.	MISCELLANEOUS: Antibodies that recognize both Epstein-Barr virus EBNA1 and HEPACAM/GlialCAM can be produced when B cells undergo somatic hypermutations. HEPACAM/GlialCAM can thus become an autoantigen for self-directed autoimmunity and possibly contribute to the events leading to multiple sclerosis. {ECO:0000269|PubMed:35073561}.	cell adhesion [GO:0007155]; cell cycle [GO:0007049]; protein localization [GO:0008104]; regulation of cell cycle [GO:0051726]	axon [GO:0030424]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; membrane [GO:0016020]		axon [GO:0030424]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; membrane [GO:0016020]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; protein localization [GO:0008104]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15885354, ECO:0000269|PubMed:15917256}. Membrane; Single-pass type I membrane protein; Cytoplasmic side {ECO:0000269|PubMed:15885354, ECO:0000269|PubMed:15917256}. Note=In MCF-7 breast carcinoma and hepatic Hep 3B2.1-7 and Hep-G2 cell lines, localization of HEPACAM is cell density-dependent. In well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, and at cell surface of protusions. In confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts. Colocalizes with CDH1.
Q14D04	reviewed	MELT_HUMAN	Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted)	VEPH1 KIAA1692 VEPH	Homo sapiens (Human)	833	FUNCTION: Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. {ECO:0000269|PubMed:26039994}.		negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of signal transduction [GO:0009966]	plasma membrane [GO:0005886]	phosphatidylinositol-5-phosphate binding [GO:0010314]	plasma membrane [GO:0005886]; phosphatidylinositol-5-phosphate binding [GO:0010314]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26039994}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9VS24}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9VS24}.
Q14D33	reviewed	RTP5_HUMAN	Receptor-transporting protein 5 (3CxxC-type zinc finger protein 5) (CXXC-type zinc finger protein 11)	RTP5 C2orf85 CXXC11 Z3CXXC5	Homo sapiens (Human)	572			detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612]	membrane [GO:0016020]	metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849]	membrane [GO:0016020]; metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q15003	reviewed	CND2_HUMAN	Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog)	NCAPH BRRN BRRN1 CAPH KIAA0074	Homo sapiens (Human)	741	FUNCTION: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}.		cell division [GO:0051301]; female meiosis chromosome separation [GO:0051309]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]	condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; cell division [GO:0051301]; female meiosis chromosome separation [GO:0051309]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11694586}. Cytoplasm {ECO:0000269|PubMed:11694586}. Chromosome {ECO:0000269|PubMed:11694586}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Q15004	reviewed	PAF15_HUMAN	PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor)	PCLAF KIAA0101 NS5ATP9 PAF L5	Homo sapiens (Human)	111	FUNCTION: PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}.	MISCELLANEOUS: Overexpression in adrenocortical neoplasms (ACC), may promote growth and invasion in adrenal cancer. {ECO:0000305|PubMed:22096502}.	centrosome cycle [GO:0007098]; DNA damage response [GO:0006974]; DNA replication [GO:0006260]; regulation of cell cycle [GO:0051726]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]	centrosome [GO:0005813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090]	centrosome [GO:0005813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090]; centrosome cycle [GO:0007098]; DNA damage response [GO:0006974]; DNA replication [GO:0006260]; regulation of cell cycle [GO:0051726]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11313979, ECO:0000269|PubMed:16288740, ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21673012}. Note=Following DNA damage, localizes to DNA damage sites (PubMed:21628590). Colocalizes with centrosomes in perinuclear region (PubMed:21673012).
Q15005	reviewed	SPCS2_HUMAN	Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit)	SPCS2 KIAA0102 SPC25	Homo sapiens (Human)	226	FUNCTION: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). {ECO:0000250|UniProtKB:Q04969, ECO:0000269|PubMed:34388369}.		protein targeting to ER [GO:0045047]; signal peptide processing [GO:0006465]	endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787]		endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787]; protein targeting to ER [GO:0045047]; signal peptide processing [GO:0006465]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q28250}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q28250}.
Q15006	reviewed	EMC2_HUMAN	ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35)	EMC2 KIAA0103 TTC35	Homo sapiens (Human)	297	FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656, PubMed:33964204). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000269|PubMed:33964204, ECO:0000305}.		protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	cytoplasm [GO:0005737]; EMC complex [GO:0072546]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of endoplasmic reticulum membrane [GO:0042406]		cytoplasm [GO:0005737]; EMC complex [GO:0072546]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of endoplasmic reticulum membrane [GO:0042406]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Peripheral membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}; Cytoplasmic side {ECO:0000269|PubMed:22119785, ECO:0000269|PubMed:32439656}. Note=May also localize to the nuclear envelope. {ECO:0000250|UniProtKB:Q9CRD2}.
Q15007	reviewed	FL2D_HUMAN	Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein)	WTAP KIAA0105	Homo sapiens (Human)	396	FUNCTION: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724). {ECO:0000269|PubMed:12444081, ECO:0000269|PubMed:17088532, ECO:0000269|PubMed:17095724, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}.		cell cycle [GO:0007049]; mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; identical protein binding [GO:0042802]; cell cycle [GO:0007049]; mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:24407421}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11001926, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:26458103}. Cytoplasm {ECO:0000250|UniProtKB:Q9ER69}. Note=Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus. {ECO:0000250|UniProtKB:Q9ER69}.
Q15008	reviewed	PSMD6_HUMAN	26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)	PSMD6 KIAA0107 PFAAP4	Homo sapiens (Human)	389	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; secretory granule lumen [GO:0034774]		cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; secretory granule lumen [GO:0034774]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	
Q15011	reviewed	HERP1_HUMAN	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1)	HERPUD1 HERP KIAA0025 MIF1	Homo sapiens (Human)	391	FUNCTION: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405). Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982). {ECO:0000269|PubMed:16289116, ECO:0000269|PubMed:18307982, ECO:0000269|PubMed:28827405}.	MISCELLANEOUS: Although the precise topology is not known, experimental data suggest that both the N- and C-termini face the cytosol.	endoplasmic reticulum calcium ion homeostasis [GO:0032469]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; protein targeting to ER [GO:0045047]; regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903069]; regulation of protein ubiquitination [GO:0031396]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Lewy body core [GO:1990037]; membrane [GO:0016020]	transmembrane transporter binding [GO:0044325]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Lewy body core [GO:1990037]; membrane [GO:0016020]; transmembrane transporter binding [GO:0044325]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; protein targeting to ER [GO:0045047]; regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903069]; regulation of protein ubiquitination [GO:0031396]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10922362}; Multi-pass membrane protein {ECO:0000269|PubMed:10922362}.
Q15012	reviewed	LAP4A_HUMAN	Lysosomal-associated transmembrane protein 4A (Golgi 4-transmembrane-spanning transporter MTP)	LAPTM4A KIAA0108 LAPTM4 MBNT MTRP UNQ1846/PRO3574	Homo sapiens (Human)	233	FUNCTION: May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. {ECO:0000250}.			Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]		Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=May reside in an intracellular membrane-bound compartment. {ECO:0000305}.
Q15013	reviewed	MD2BP_HUMAN	MAD2L1-binding protein (Caught by MAD2 protein) (p31(comet))	MAD2L1BP CMT2 KIAA0110	Homo sapiens (Human)	274	FUNCTION: May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. {ECO:0000269|PubMed:18022368}.		deactivation of mitotic spindle assembly checkpoint [GO:1902426]; regulation of exit from mitosis [GO:0007096]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]		cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; deactivation of mitotic spindle assembly checkpoint [GO:1902426]; regulation of exit from mitosis [GO:0007096]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
Q15014	reviewed	MO4L2_HUMAN	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX)	MORF4L2 KIAA0026 MRGX	Homo sapiens (Human)	288	FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.		chromatin organization [GO:0006325]; DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]	NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; plasma membrane [GO:0005886]		NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; plasma membrane [GO:0005886]; chromatin organization [GO:0006325]; DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]	SUBCELLULAR LOCATION: Nucleus.
Q15018	reviewed	ABRX2_HUMAN	BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B)	ABRAXAS2 ABRO1 FAM175B KIAA0157	Homo sapiens (Human)	415	FUNCTION: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}.		attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; protein K63-linked deubiquitination [GO:0070536]; response to ischemia [GO:0002931]	BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle pole [GO:0000922]	microtubule binding [GO:0008017]; polyubiquitin modification-dependent protein binding [GO:0031593]	BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle pole [GO:0000922]; microtubule binding [GO:0008017]; polyubiquitin modification-dependent protein binding [GO:0031593]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; protein K63-linked deubiquitination [GO:0070536]; response to ischemia [GO:0002931]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:21195082, ECO:0000269|PubMed:21282113, ECO:0000269|PubMed:22974638, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}. Nucleus {ECO:0000269|PubMed:21282113, ECO:0000269|PubMed:22974638, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:26195665}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26195665}. Note=A minor proportion is detected in the nucleus (PubMed:21282113, PubMed:22974638). Translocates into the nucleus in response to DNA damage (PubMed:25283148). Directly binds to microtubules and is detected at the minus end of K-fibers (PubMed:26195665). Co-localizes with NUMA1 at mitotic spindle poles (PubMed:26195665). {ECO:0000269|PubMed:21282113, ECO:0000269|PubMed:22974638, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:26195665}.
Q15019	reviewed	SEPT2_HUMAN	Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5)	SEPTIN2 DIFF6 KIAA0158 NEDD5 SEPT2	Homo sapiens (Human)	361	FUNCTION: Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000269|PubMed:15774761, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18209106, ECO:0000269|PubMed:19145258, ECO:0000305|PubMed:25588830}.	MISCELLANEOUS: Coordinated expression with SEPTIN6 and SEPTIN7.	cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of exocytosis [GO:0017157]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]	actin cytoskeleton [GO:0015629]; axoneme [GO:0005930]; cell division site [GO:0032153]; ciliary membrane [GO:0060170]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; non-motile cilium [GO:0097730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]	cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]	actin cytoskeleton [GO:0015629]; axoneme [GO:0005930]; cell division site [GO:0032153]; ciliary membrane [GO:0060170]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; non-motile cilium [GO:0097730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]; cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of exocytosis [GO:0017157]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15774761}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15774761}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15774761}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15774761}. Cleavage furrow {ECO:0000269|PubMed:15774761}. Midbody {ECO:0000269|PubMed:15774761}. Cytoplasm, cell cortex {ECO:0000269|PubMed:15774761}. Cell projection, cilium membrane {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:25588830}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. In epithelial cells, colocalizes with polyglutamylated tubulin around the trans-Golgi network, as well as juxatnuclear and proximal Golgi apparatus. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes. Found in the sperm annulus (PubMed:25588830). {ECO:0000269|PubMed:25588830}.
Q15020	reviewed	SART3_HUMAN	Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein)	SART3 KIAA0156 TIP110	Homo sapiens (Human)	963	FUNCTION: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). {ECO:0000250|UniProtKB:Q9JLI8, ECO:0000269|PubMed:12032085, ECO:0000269|PubMed:14749385, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:24526689}.; FUNCTION: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. {ECO:0000269|PubMed:11959860}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Inactive in U4/U6 snRNP recycling. {ECO:0000269|PubMed:15314151}.	cell morphogenesis [GO:0000902]; hematopoietic stem cell proliferation [GO:0071425]; homeostasis of number of cells [GO:0048872]; mRNA splicing, via spliceosome [GO:0000398]; nucleosome assembly [GO:0006334]; regulation of gene expression [GO:0010468]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]; transcription elongation-coupled chromatin remodeling [GO:0140673]	ASAP complex [GO:0061574]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone binding [GO:0042393]; RNA binding [GO:0003723]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]; U6atac snRNA binding [GO:0030624]; ubiquitin-specific protease binding [GO:1990381]	ASAP complex [GO:0061574]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone binding [GO:0042393]; RNA binding [GO:0003723]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]; U6atac snRNA binding [GO:0030624]; ubiquitin-specific protease binding [GO:1990381]; cell morphogenesis [GO:0000902]; hematopoietic stem cell proliferation [GO:0071425]; homeostasis of number of cells [GO:0048872]; mRNA splicing, via spliceosome [GO:0000398]; nucleosome assembly [GO:0006334]; regulation of gene expression [GO:0010468]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]; transcription elongation-coupled chromatin remodeling [GO:0140673]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:10463607, ECO:0000269|PubMed:11959860, ECO:0000269|PubMed:12578909}. Nucleus, Cajal body {ECO:0000269|PubMed:12578909}. Nucleus speckle {ECO:0000269|PubMed:11959860}. Cytoplasm {ECO:0000269|PubMed:10463607, ECO:0000269|PubMed:11959860}.
Q15021	reviewed	CND1_HUMAN	Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog)	NCAPD2 CAPD2 CNAP1 KIAA0159	Homo sapiens (Human)	1401	FUNCTION: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}.		cell division [GO:0051301]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	condensed chromosome [GO:0000793]; condensed chromosome, centromeric region [GO:0000779]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone binding [GO:0042393]	condensed chromosome [GO:0000793]; condensed chromosome, centromeric region [GO:0000779]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone binding [GO:0042393]; cell division [GO:0051301]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Q15022	reviewed	SUZ12_HUMAN	Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog)	SUZ12 CHET9 JJAZ1 KIAA0160	Homo sapiens (Human)	739	FUNCTION: Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.	MISCELLANEOUS: Under hypoxic conditions, the precursor SUZ12 RNA undergoes regulated trans-splicing with the JAZF1 RNA, resulting in a chimeric isoform which may be protective against apoptosis. The chimeric transcript is characterized by JAZF1 exons 1-3 joined to SUZ12 exon 2-16. The chimeric transcript is expressed primarily in the endometrium from late secretory and early proliferative phases of the menstrual cycle, but not in normal myometrium at any phase of the cycle. Its expression is slightly induced by low levels of progesterone, but suppressed by both estrogen and high levels of progesterone (PubMed:18772439). {ECO:0000305|PubMed:18772439}.	cell population proliferation [GO:0008283]; dosage compensation by inactivation of X chromosome [GO:0009048]; facultative heterochromatin formation [GO:0140718]; negative regulation of cell differentiation [GO:0045596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell population proliferation [GO:0008284]	chromatin silencing complex [GO:0005677]; ESC/E(Z) complex [GO:0035098]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RSC-type complex [GO:0016586]; sex chromatin [GO:0001739]	chromatin DNA binding [GO:0031490]; enzyme activator activity [GO:0008047]; histone methyltransferase activity [GO:0042054]; lncRNA binding [GO:0106222]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]	chromatin silencing complex [GO:0005677]; ESC/E(Z) complex [GO:0035098]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RSC-type complex [GO:0016586]; sex chromatin [GO:0001739]; chromatin DNA binding [GO:0031490]; enzyme activator activity [GO:0008047]; histone methyltransferase activity [GO:0042054]; lncRNA binding [GO:0106222]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]; cell population proliferation [GO:0008283]; dosage compensation by inactivation of X chromosome [GO:0009048]; facultative heterochromatin formation [GO:0140718]; negative regulation of cell differentiation [GO:0045596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.
Q15024	reviewed	EXOS7_HUMAN	Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8)	EXOSC7 KIAA0116 RRP42	Homo sapiens (Human)	291	FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.		exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5'-RNA exonuclease activity [GO:0000175]; RNA binding [GO:0003723]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5'-RNA exonuclease activity [GO:0000175]; RNA binding [GO:0003723]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}.
Q15025	reviewed	TNIP1_HUMAN	TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)	TNIP1 KIAA0113 NAF1	Homo sapiens (Human)	636	FUNCTION: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814, ECO:0000269|PubMed:21885437}.	MISCELLANEOUS: [Isoform 5]: Less effective in the NF-kappa-B inhibitory effect. {ECO:0000305}.	cellular response to lipopolysaccharide [GO:0071222]; defense response [GO:0006952]; glycoprotein biosynthetic process [GO:0009101]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of viral genome replication [GO:0045071]; positive regulation of inflammatory response [GO:0050729]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; translation [GO:0006412]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019]; cellular response to lipopolysaccharide [GO:0071222]; defense response [GO:0006952]; glycoprotein biosynthetic process [GO:0009101]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of viral genome replication [GO:0045071]; positive regulation of inflammatory response [GO:0050729]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.
Q15027	reviewed	ACAP1_HUMAN	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1)	ACAP1 CENTB1 KIAA0050	Homo sapiens (Human)	740	FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17398097, ECO:0000269|PubMed:17664335, ECO:0000269|PubMed:22645133}.	MISCELLANEOUS: Cells overexpressing ACAP1 show an accumulation of ITGB1 in recycling endosomes and inhibition of stimulation-dependent cell migration. Cells with reduced levels of ACAP1 or AKT1 and AKT2 show inhibition of stimulation-dependent cell migration. Cells overexpressing ACAP1 and PIP5K1C show formation of tubular structures derived from endosomal membranes.	protein transport [GO:0015031]	membrane [GO:0016020]; recycling endosome membrane [GO:0055038]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	membrane [GO:0016020]; recycling endosome membrane [GO:0055038]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:16256741}; Peripheral membrane protein {ECO:0000269|PubMed:16256741}; Cytoplasmic side {ECO:0000269|PubMed:16256741}.
Q15029	reviewed	U5S1_HUMAN	116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)	EFTUD2 KIAA0031 SNRP116	Homo sapiens (Human)	972	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30705154, PubMed:25092792). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:25092792, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000305|PubMed:33509932}.		cellular response to xenobiotic stimulus [GO:0071466]; mRNA splicing, via spliceosome [GO:0000398]; response to cocaine [GO:0042220]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; U5 snRNA binding [GO:0030623]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; U5 snRNA binding [GO:0030623]; cellular response to xenobiotic stimulus [GO:0071466]; mRNA splicing, via spliceosome [GO:0000398]; response to cocaine [GO:0042220]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154}.
Q15031	reviewed	SYLM_HUMAN	Leucine--tRNA ligase, mitochondrial (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)	LARS2 KIAA0028	Homo sapiens (Human)	903	FUNCTION: Catalyzes the attachment of leucine to its cognate tRNA. {ECO:0000269|PubMed:26537577}.		leucyl-tRNA aminoacylation [GO:0006429]; mitochondrial translation [GO:0032543]; tRNA aminoacylation for protein translation [GO:0006418]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; leucine-tRNA ligase activity [GO:0004823]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; leucine-tRNA ligase activity [GO:0004823]; leucyl-tRNA aminoacylation [GO:0006429]; mitochondrial translation [GO:0032543]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
Q15036	reviewed	SNX17_HUMAN	Sorting nexin-17	SNX17 KIAA0064	Homo sapiens (Human)	470	FUNCTION: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:28892079, PubMed:22492727). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}.		aorta development [GO:0035904]; cardiac septum development [GO:0003279]; cholesterol catabolic process [GO:0006707]; coronary vasculature development [GO:0060976]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; receptor-mediated endocytosis [GO:0006898]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; protein-containing complex [GO:0032991]	low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol binding [GO:0035091]; signaling receptor binding [GO:0005102]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol binding [GO:0035091]; signaling receptor binding [GO:0005102]; aorta development [GO:0035904]; cardiac septum development [GO:0003279]; cholesterol catabolic process [GO:0006707]; coronary vasculature development [GO:0060976]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; receptor-mediated endocytosis [GO:0006898]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11237770, ECO:0000269|PubMed:21512128}. Early endosome {ECO:0000269|PubMed:14739284, ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:28892079}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:11237770, ECO:0000269|PubMed:16712798}; Peripheral membrane protein {ECO:0000269|PubMed:11237770}; Cytoplasmic side {ECO:0000269|PubMed:11237770}.
Q15038	reviewed	DAZP2_HUMAN	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2) (Proline-rich transcript in brain protein)	DAZAP2 KIAA0058 PRTB	Homo sapiens (Human)	168	FUNCTION: In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1 (PubMed:33591310). In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters (PubMed:33591310). This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death (PubMed:33591310). Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (By similarity). Plays a role in stress granule formation (PubMed:17984221). {ECO:0000250|UniProtKB:Q9DCP9, ECO:0000269|PubMed:17984221, ECO:0000269|PubMed:33591310}.		positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; protein destabilization [GO:0031648]; stress granule assembly [GO:0034063]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; p53 binding [GO:0002039]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase binding [GO:0120283]; receptor tyrosine kinase binding [GO:0030971]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; p53 binding [GO:0002039]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase binding [GO:0120283]; receptor tyrosine kinase binding [GO:0030971]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; protein destabilization [GO:0031648]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17935665, ECO:0000269|PubMed:17984221, ECO:0000269|PubMed:19304756, ECO:0000269|PubMed:22070932, ECO:0000269|PubMed:33591310}. Nucleus {ECO:0000269|PubMed:17984221, ECO:0000269|PubMed:19304756, ECO:0000269|PubMed:21274613, ECO:0000269|PubMed:22070932, ECO:0000269|PubMed:33591310}. Nucleus speckle {ECO:0000269|PubMed:11342538}. Nucleus, nuclear body {ECO:0000269|PubMed:33591310}. Cytoplasm, Stress granule {ECO:0000269|PubMed:17984221, ECO:0000269|PubMed:33591310}. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm (PubMed:22070932). Predominantly cytoplasmic when unphosphorylated and localizes to the nucleus following phosphorylation by HIPK2 (PubMed:33591310). Localizes to stress granules under cellular stress conditions (PubMed:17984221). {ECO:0000269|PubMed:17984221, ECO:0000269|PubMed:22070932, ECO:0000269|PubMed:33591310}.
Q15040	reviewed	JOS1_HUMAN	Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1)	JOSD1 JSPH1 KIAA0063	Homo sapiens (Human)	202	FUNCTION: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. {ECO:0000269|PubMed:21118805, ECO:0000269|PubMed:23625928}.		proteolysis [GO:0006508]	cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23625928}. Cytoplasm {ECO:0000269|PubMed:23625928}. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding.
Q15041	reviewed	AR6P1_HUMAN	ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Apoptotic regulator in the membrane of the endoplasmic reticulum)	ARL6IP1 ARL6IP ARMER KIAA0069	Homo sapiens (Human)	203	FUNCTION: Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579). {ECO:0000250|UniProtKB:Q9JKW0, ECO:0000269|PubMed:12754298, ECO:0000269|PubMed:24262037, ECO:0000303|PubMed:10995579}.		apoptotic process [GO:0006915]; cotranslational protein targeting to membrane [GO:0006613]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; positive regulation of L-glutamate import across plasma membrane [GO:0002038]; regulation of endoplasmic reticulum tubular network organization [GO:1903371]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; Sec61 translocon complex [GO:0005784]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; Sec61 translocon complex [GO:0005784]; identical protein binding [GO:0042802]; apoptotic process [GO:0006915]; cotranslational protein targeting to membrane [GO:0006613]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; positive regulation of L-glutamate import across plasma membrane [GO:0002038]; regulation of endoplasmic reticulum tubular network organization [GO:1903371]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:10995579}; Multi-pass membrane protein {ECO:0000269|PubMed:10995579}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12754298, ECO:0000269|PubMed:24076029, ECO:0000269|PubMed:24262037}; Multi-pass membrane protein {ECO:0000269|PubMed:24076029}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9JKW0}. Note=Predominantly localized to intracytoplasmic membranes. Preferentially localizes at the ER tubules and the edge of the ER sheets, both of which are characterized by a high membrane curvature. {ECO:0000269|PubMed:24262037}.
Q15042	reviewed	RB3GP_HUMAN	Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP)	RAB3GAP1 KIAA0066 RAB3GAP	Homo sapiens (Human)	981	FUNCTION: Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:9030515, PubMed:10859313, PubMed:24891604). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (PubMed:10859313). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (PubMed:15696165). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (PubMed:15696165, PubMed:23420520). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (PubMed:9030515, PubMed:9852129). {ECO:0000269|PubMed:10859313, ECO:0000269|PubMed:15696165, ECO:0000269|PubMed:23420520, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:9030515, ECO:0000269|PubMed:9852129}.		brain development [GO:0007420]; camera-type eye development [GO:0043010]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; excitatory postsynaptic potential [GO:0060079]; face morphogenesis [GO:0060325]; hypothalamus development [GO:0021854]; lipid droplet organization [GO:0034389]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein lipidation [GO:1903061]; regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903233]; regulation of GTPase activity [GO:0043087]; regulation of short-term neuronal synaptic plasticity [GO:0048172]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; excitatory postsynaptic potential [GO:0060079]; face morphogenesis [GO:0060325]; hypothalamus development [GO:0021854]; lipid droplet organization [GO:0034389]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein lipidation [GO:1903061]; regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903233]; regulation of GTPase activity [GO:0043087]; regulation of short-term neuronal synaptic plasticity [GO:0048172]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:9852129}. Endoplasmic reticulum {ECO:0000269|PubMed:24891604}. Note=In neurons, it is enriched in the synaptic soluble fraction. {ECO:0000269|PubMed:9852129}.
Q15043	reviewed	S39AE_HUMAN	Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14)	SLC39A14 KIAA0062 ZIP14	Homo sapiens (Human)	492	FUNCTION: Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:15642354, PubMed:27231142, PubMed:29621230). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (By similarity). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010). Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (By similarity). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174). Also involved in manganese extracellular uptake by cells of the blood-brain barrier (PubMed:31699897). May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (By similarity). Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (PubMed:23052185). {ECO:0000250|UniProtKB:Q75N73, ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:20682781, ECO:0000269|PubMed:23052185, ECO:0000269|PubMed:27231142, ECO:0000269|PubMed:27703010, ECO:0000269|PubMed:29621230, ECO:0000269|PubMed:31028174, ECO:0000269|PubMed:31699897}.		cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; chondrocyte differentiation [GO:0002062]; gluconeogenesis [GO:0006094]; import across plasma membrane [GO:0098739]; inorganic cation transmembrane transport [GO:0098662]; insulin receptor signaling pathway [GO:0008286]; intracellular zinc ion homeostasis [GO:0006882]; iron import into cell [GO:0033212]; iron ion transmembrane transport [GO:0034755]; manganese ion homeostasis [GO:0055071]; manganese ion transmembrane transport [GO:0071421]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; regulation of hormone levels [GO:0010817]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cadmium ion transmembrane transporter activity [GO:0015086]; ferrous iron transmembrane transporter activity [GO:0015093]; iron ion transmembrane transporter activity [GO:0005381]; manganese ion transmembrane transporter activity [GO:0005384]; monoatomic anion:monoatomic cation symporter activity [GO:0015296]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cadmium ion transmembrane transporter activity [GO:0015086]; ferrous iron transmembrane transporter activity [GO:0015093]; iron ion transmembrane transporter activity [GO:0005381]; manganese ion transmembrane transporter activity [GO:0005384]; monoatomic anion:monoatomic cation symporter activity [GO:0015296]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; chondrocyte differentiation [GO:0002062]; gluconeogenesis [GO:0006094]; import across plasma membrane [GO:0098739]; inorganic cation transmembrane transport [GO:0098662]; insulin receptor signaling pathway [GO:0008286]; intracellular zinc ion homeostasis [GO:0006882]; iron import into cell [GO:0033212]; iron ion transmembrane transport [GO:0034755]; manganese ion homeostasis [GO:0055071]; manganese ion transmembrane transport [GO:0071421]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; regulation of hormone levels [GO:0010817]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:27231142, ECO:0000269|PubMed:27703010, ECO:0000269|PubMed:29621230}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:31699897}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:31028174, ECO:0000269|PubMed:31699897}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:20682781, ECO:0000269|PubMed:27703010}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:27703010}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:20682781}; Multi-pass membrane protein {ECO:0000255}. Note=Localized and functional at both apical and basolateral membranes of microvascular capillary endothelial cells that constitute the blood-brain barrier (PubMed:31699897). Localized at the basolateral membrane of enterocytes (PubMed:31028174). Enriched at the plasma membrane upon glucose uptake (PubMed:27703010). {ECO:0000269|PubMed:27703010, ECO:0000269|PubMed:31028174, ECO:0000269|PubMed:31699897}.
Q15046	reviewed	SYK_HUMAN	Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)	KARS1 KARS KIAA0070	Homo sapiens (Human)	597	FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739). {ECO:0000269|PubMed:14975237, ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:18029264, ECO:0000269|PubMed:19524539, ECO:0000269|PubMed:28887846, ECO:0000269|PubMed:5338216, ECO:0000269|PubMed:9278442}.; FUNCTION: (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. {ECO:0000269|PubMed:15220430}.	MISCELLANEOUS: Shares a bidirectional promoter with TERF2IP/RAP1. {ECO:0000305|PubMed:14659874}.; MISCELLANEOUS: [Isoform Mitochondrial]: Mitochondrial precursor. Contains a mitochondrial transit peptide at positions 1-16. {ECO:0000305}.	basophil activation involved in immune response [GO:0002276]; diadenosine tetraphosphate biosynthetic process [GO:0015966]; ERK1 and ERK2 cascade [GO:0070371]; lysyl-tRNA aminoacylation [GO:0006430]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of macrophage activation [GO:0043032]; response to X-ray [GO:0010165]; tRNA processing [GO:0008033]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	amino acid binding [GO:0016597]; ATP adenylyltransferase activity [GO:0003877]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; lysine-tRNA ligase activity [GO:0004824]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; amino acid binding [GO:0016597]; ATP adenylyltransferase activity [GO:0003877]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; lysine-tRNA ligase activity [GO:0004824]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; basophil activation involved in immune response [GO:0002276]; diadenosine tetraphosphate biosynthetic process [GO:0015966]; ERK1 and ERK2 cascade [GO:0070371]; lysyl-tRNA aminoacylation [GO:0006430]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of macrophage activation [GO:0043032]; response to X-ray [GO:0010165]; tRNA processing [GO:0008033]	SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm, cytosol {ECO:0000269|PubMed:10952987, ECO:0000269|PubMed:19289464, ECO:0000269|PubMed:23159739, ECO:0000269|PubMed:28887846}. Cytoplasm {ECO:0000269|PubMed:15220430}. Nucleus {ECO:0000269|PubMed:15220430, ECO:0000269|PubMed:23159739}. Cell membrane {ECO:0000269|PubMed:15220430}; Peripheral membrane protein {ECO:0000269|PubMed:15220430}. Secreted {ECO:0000269|PubMed:15851690}. Note=Secretion is induced by TNF-alpha (PubMed:15851690). Cytosolic in quiescent mast cells. Translocates into the nucleus in response to mast cell activation by immunoglobulin E (PubMed:23159739). {ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:23159739}.; SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion {ECO:0000269|PubMed:10952987}.
Q15047	reviewed	SETB1_HUMAN	Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)	SETDB1 ESET KIAA0067 KMT1E	Homo sapiens (Human)	1291	FUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:27732843, PubMed:14536086). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27732843}.	MISCELLANEOUS: Highly up-regulated in Huntington disease patients, suggesting that participates in the altered chromatin modulation and transcription dysfunction observed in Huntington disease. Its down-regulation has salubrious effects on patients, suggesting that it may be a promising treatment in Huntington disease patients.	heterochromatin organization [GO:0070828]; methylation [GO:0032259]; negative regulation of gene expression [GO:0010629]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone H3K9me2 methyltransferase activity [GO:0140947]; promoter-specific chromatin binding [GO:1990841]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone H3K9me2 methyltransferase activity [GO:0140947]; promoter-specific chromatin binding [GO:1990841]; zinc ion binding [GO:0008270]; heterochromatin organization [GO:0070828]; methylation [GO:0032259]; negative regulation of gene expression [GO:0010629]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27732843}. Cytoplasm {ECO:0000269|PubMed:27732843}. Chromosome. Note=Associated with non-pericentromeric regions of chromatin. Excluded from nucleoli and islands of condensed chromatin. {ECO:0000269|PubMed:27732843}.
Q15049	reviewed	MLC1_HUMAN	Membrane protein MLC1	MLC1 KIAA0027 WKL1	Homo sapiens (Human)	377	FUNCTION: Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. {ECO:0000269|PubMed:22328087}.		caveolin-mediated endocytosis [GO:0072584]; cellular response to cholesterol [GO:0071397]; monoatomic ion transport [GO:0006811]; positive regulation of intracellular transport [GO:0032388]; protein transport [GO:0015031]; regulation of response to osmotic stress [GO:0047484]; vesicle-mediated transport [GO:0016192]	basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; caveolin-mediated endocytosis [GO:0072584]; cellular response to cholesterol [GO:0071397]; monoatomic ion transport [GO:0006811]; positive regulation of intracellular transport [GO:0032388]; protein transport [GO:0015031]; regulation of response to osmotic stress [GO:0047484]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:22328087}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:22328087}. Endoplasmic reticulum {ECO:0000269|PubMed:22328087}.
Q15050	reviewed	RRS1_HUMAN	Ribosome biogenesis regulatory protein homolog	RRS1 KIAA0112 RRR	Homo sapiens (Human)	365	FUNCTION: Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. {ECO:0000269|PubMed:24120868}.		endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic metaphase chromosome alignment [GO:0007080]; protein localization to nucleolus [GO:1902570]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]	condensed nuclear chromosome [GO:0000794]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]	5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]	condensed nuclear chromosome [GO:0000794]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]; 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic metaphase chromosome alignment [GO:0007080]; protein localization to nucleolus [GO:1902570]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|Ref.3}.
Q15051	reviewed	IQCB1_HUMAN	IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ)	IQCB1 KIAA0036 NPHP5 OK/SW-cl.85	Homo sapiens (Human)	598	FUNCTION: Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655). {ECO:0000269|PubMed:23446637, ECO:0000269|PubMed:25552655}.	MISCELLANEOUS: [Isoform 2]: Low abundance isoform. {ECO:0000305}.	cilium assembly [GO:0060271]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]	centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]	calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]	centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; cilium assembly [GO:0060271]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21565611}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23446637}. Note=Localization to the centrosome depends on the interaction with CEP290/NPHP6.
Q15052	reviewed	ARHG6_HUMAN	Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)	ARHGEF6 COOL2 KIAA0006 PIXA	Homo sapiens (Human)	776	FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF).		apoptotic process [GO:0006915]; JNK cascade [GO:0007254]; lamellipodium assembly [GO:0030032]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; apoptotic process [GO:0006915]; JNK cascade [GO:0007254]; lamellipodium assembly [GO:0030032]	SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000250}.
Q15054	reviewed	DPOD3_HUMAN	DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68)	POLD3 KIAA0039	Homo sapiens (Human)	466	FUNCTION: Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:22801543, PubMed:17317665, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the tetrametric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:10219083, ECO:0000269|PubMed:10852724, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:25628356, ECO:0000269|PubMed:27185888}.		DNA biosynthetic process [GO:0071897]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; DNA synthesis involved in UV-damage excision repair [GO:1904161]; DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276]; mismatch repair [GO:0006298]; nucleotide-excision repair, DNA gap filling [GO:0006297]	cytoplasm [GO:0005737]; delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654]; zeta DNA polymerase complex [GO:0016035]	protein-macromolecule adaptor activity [GO:0030674]	cytoplasm [GO:0005737]; delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654]; zeta DNA polymerase complex [GO:0016035]; protein-macromolecule adaptor activity [GO:0030674]; DNA biosynthetic process [GO:0071897]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; DNA synthesis involved in UV-damage excision repair [GO:1904161]; DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276]; mismatch repair [GO:0006298]; nucleotide-excision repair, DNA gap filling [GO:0006297]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9EQ28}. Nucleus {ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:22801543}. Note=Partially colocalizes with PCNA and POLD1 at S phase replication sites (PubMed:11595739). Recruited to DNA damage sites within 2 hours following UV irradiation (PubMed:20227374, PubMed:22801543). {ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:22801543}.
Q15056	reviewed	IF4H_HUMAN	Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein)	EIF4H KIAA0038 WBSCR1 WSCR1	Homo sapiens (Human)	248	FUNCTION: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}.		developmental growth [GO:0048589]; regulation of translational initiation [GO:0006446]; sexual reproduction [GO:0019953]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; developmental growth [GO:0048589]; regulation of translational initiation [GO:0006446]; sexual reproduction [GO:0019953]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
Q15057	reviewed	ACAP2_HUMAN	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2)	ACAP2 CENTB2 KIAA0041	Homo sapiens (Human)	778	FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). {ECO:0000269|PubMed:11062263}.		actin filament-based process [GO:0030029]; cellular response to nerve growth factor stimulus [GO:1990090]; endocytic recycling [GO:0032456]	endosome membrane [GO:0010008]; membrane [GO:0016020]; ruffle [GO:0001726]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	endosome membrane [GO:0010008]; membrane [GO:0016020]; ruffle [GO:0001726]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; actin filament-based process [GO:0030029]; cellular response to nerve growth factor stimulus [GO:1990090]; endocytic recycling [GO:0032456]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q15058	reviewed	KIF14_HUMAN	Kinesin-like protein KIF14	KIF14 KIAA0042	Homo sapiens (Human)	1648	FUNCTION: Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}.	MISCELLANEOUS: It is resistant to docetaxel anhydrous. {ECO:0000269|PubMed:24784001}.	activation of protein kinase activity [GO:0032147]; cell division [GO:0051301]; cell proliferation in forebrain [GO:0021846]; cerebellar cortex development [GO:0021695]; cerebellar granular layer structural organization [GO:0021685]; cerebellar Purkinje cell layer structural organization [GO:0021693]; cerebral cortex development [GO:0021987]; establishment of protein localization [GO:0045184]; hippocampus development [GO:0021766]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of integrin activation [GO:0033624]; negative regulation of neuron apoptotic process [GO:0043524]; olfactory bulb development [GO:0021772]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of cell growth [GO:0001558]; regulation of cell maturation [GO:1903429]; regulation of cell migration [GO:0030334]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of myelination [GO:0031641]; regulation of neuron apoptotic process [GO:0043523]; regulation of Rap protein signal transduction [GO:0032487]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; substrate adhesion-dependent cell spreading [GO:0034446]	cytosol [GO:0005829]; Flemming body [GO:0090543]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle midzone [GO:0051233]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; PDZ domain binding [GO:0030165]; plus-end-directed microtubule motor activity [GO:0008574]; protein kinase binding [GO:0019901]; tubulin binding [GO:0015631]	cytosol [GO:0005829]; Flemming body [GO:0090543]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle midzone [GO:0051233]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; PDZ domain binding [GO:0030165]; plus-end-directed microtubule motor activity [GO:0008574]; protein kinase binding [GO:0019901]; tubulin binding [GO:0015631]; activation of protein kinase activity [GO:0032147]; cell division [GO:0051301]; cell proliferation in forebrain [GO:0021846]; cerebellar cortex development [GO:0021695]; cerebellar granular layer structural organization [GO:0021685]; cerebellar Purkinje cell layer structural organization [GO:0021693]; cerebral cortex development [GO:0021987]; establishment of protein localization [GO:0045184]; hippocampus development [GO:0021766]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of integrin activation [GO:0033624]; negative regulation of neuron apoptotic process [GO:0043524]; olfactory bulb development [GO:0021772]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of cell growth [GO:0001558]; regulation of cell maturation [GO:1903429]; regulation of cell migration [GO:0030334]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of myelination [GO:0031641]; regulation of neuron apoptotic process [GO:0043523]; regulation of Rap protein signal transduction [GO:0032487]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16431929}. Cytoplasm {ECO:0000269|PubMed:16648480}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16431929}. Midbody {ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:20309963, ECO:0000269|PubMed:28892560}. Note=Nuclear localization observed during interphase (PubMed:16431929). Nuclear localization triggered by entry into mitosis (PubMed:16648480). Cytoplasmic in interphase (PubMed:16648480). Cytoplasmic in metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring. {ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480}.
Q15059	reviewed	BRD3_HUMAN	Bromodomain-containing protein 3 (RING3-like protein)	BRD3 KIAA0043 RING3L	Homo sapiens (Human)	726	FUNCTION: Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:27105114}.		chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; lysine-acetylated histone binding [GO:0070577]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; lysine-acetylated histone binding [GO:0070577]; chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309}. Note=Detected on chromatin. {ECO:0000250|UniProtKB:Q8K2F0}.
Q15061	reviewed	WDR43_HUMAN	WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog)	WDR43 KIAA0007 UTP5	Homo sapiens (Human)	677	FUNCTION: Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). {ECO:0000250|UniProtKB:Q6ZQL4, ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}.		maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; ribosomal small subunit biogenesis [GO:0042274]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; transcription elongation factor activity [GO:0003711]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; transcription elongation factor activity [GO:0003711]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:24219289, ECO:0000269|PubMed:34516797}. Nucleus, nucleolus fibrillar center {ECO:0000269|PubMed:24219289}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q6ZQL4}.
Q15063	reviewed	POSTN_HUMAN	Periostin (PN) (Osteoblast-specific factor 2) (OSF-2)	POSTN OSF2	Homo sapiens (Human)	836	FUNCTION: Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). {ECO:0000250|UniProtKB:Q62009, ECO:0000269|PubMed:12235007}.		bone regeneration [GO:1990523]; cell adhesion [GO:0007155]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin K [GO:0071307]; extracellular matrix organization [GO:0030198]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neuron projection extension [GO:1990138]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of smooth muscle cell migration [GO:0014911]; regulation of Notch signaling pathway [GO:0008593]; regulation of systemic arterial blood pressure [GO:0003073]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to muscle activity [GO:0014850]; tissue development [GO:0009888]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; trans-Golgi network [GO:0005802]	cell adhesion molecule binding [GO:0050839]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; trans-Golgi network [GO:0005802]; cell adhesion molecule binding [GO:0050839]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; bone regeneration [GO:1990523]; cell adhesion [GO:0007155]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin K [GO:0071307]; extracellular matrix organization [GO:0030198]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neuron projection extension [GO:1990138]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of smooth muscle cell migration [GO:0014911]; regulation of Notch signaling pathway [GO:0008593]; regulation of systemic arterial blood pressure [GO:0003073]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to muscle activity [GO:0014850]; tissue development [GO:0009888]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q62009}. Secreted {ECO:0000269|PubMed:18450759, ECO:0000269|PubMed:26273833}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12235007, ECO:0000269|PubMed:18450759}. Note=Colocalizes with BMP1 in the Golgi. {ECO:0000250|UniProtKB:Q62009}.
Q15067	reviewed	ACOX1_HUMAN	Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]	ACOX1 ACOX	Homo sapiens (Human)	660	FUNCTION: Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids (PubMed:7876265, PubMed:15060085, PubMed:17458872, PubMed:17603022, PubMed:32169171, PubMed:33234382). Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)) (PubMed:7876265, PubMed:17458872, PubMed:17603022). {ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:17458872, ECO:0000269|PubMed:17603022, ECO:0000269|PubMed:32169171, ECO:0000269|PubMed:33234382, ECO:0000269|PubMed:7876265}.; FUNCTION: [Isoform 1]: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro. {ECO:0000269|PubMed:17603022}.; FUNCTION: [Isoform 2]: Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs. {ECO:0000269|PubMed:17603022}.	MISCELLANEOUS: Isoform 1 and isoform 2 can reverse the Acox1 null phenotype in mouse which is characterized by severe microvesicular hepatic steatosis, sustained activation of PPARA, spontaneous massive peroxisome proliferation and eventual development of hepatocellular carcinomas. Isoform 2 is more effective in reversal of the phenotype than isoform 1 (PubMed:20195242). {ECO:0000305|PubMed:20195242}.	cholesterol homeostasis [GO:0042632]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid catabolic process [GO:0009062]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; hydrogen peroxide biosynthetic process [GO:0050665]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; peroxisome fission [GO:0016559]; prostaglandin metabolic process [GO:0006693]; spermatogenesis [GO:0007283]; very long-chain fatty acid beta-oxidation [GO:0140493]; very long-chain fatty acid metabolic process [GO:0000038]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; palmitoyl-CoA oxidase activity [GO:0016401]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; palmitoyl-CoA oxidase activity [GO:0016401]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; cholesterol homeostasis [GO:0042632]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid catabolic process [GO:0009062]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; hydrogen peroxide biosynthetic process [GO:0050665]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; peroxisome fission [GO:0016559]; prostaglandin metabolic process [GO:0006693]; spermatogenesis [GO:0007283]; very long-chain fatty acid beta-oxidation [GO:0140493]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:32169171}.
Q15070	reviewed	OXA1L_HUMAN	Mitochondrial inner membrane protein OXA1L (Hsa) (OXA1Hs) (Oxidase assembly 1-like protein) (OXA1-like protein)	OXA1L	Homo sapiens (Human)	435	FUNCTION: Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria. {ECO:0000269|PubMed:17936786, ECO:0000269|PubMed:7991568}.		aerobic respiration [GO:0009060]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of oxidoreductase activity [GO:0051354]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein tetramerization [GO:0051262]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	membrane insertase activity [GO:0032977]; mitochondrial ribosome binding [GO:0097177]; protein homodimerization activity [GO:0042803]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; membrane insertase activity [GO:0032977]; mitochondrial ribosome binding [GO:0097177]; protein homodimerization activity [GO:0042803]; aerobic respiration [GO:0009060]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of oxidoreductase activity [GO:0051354]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein tetramerization [GO:0051262]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:17936786}; Multi-pass membrane protein {ECO:0000269|PubMed:17936786}.
Q15072	reviewed	OZF_HUMAN	Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146)	ZNF146 OZF	Homo sapiens (Human)	292			regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; heparin binding [GO:0008201]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; heparin binding [GO:0008201]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8665923}.
Q15075	reviewed	EEA1_HUMAN	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2)	EEA1 ZFYVE2	Homo sapiens (Human)	1411	FUNCTION: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.	MISCELLANEOUS: Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases.	chemical synaptic transmission, postsynaptic [GO:0099565]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; modulation by host of viral process [GO:0044788]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle fusion [GO:0006906]	axonal spine [GO:0044308]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; recycling endosome [GO:0055037]; Schaffer collateral - CA1 synapse [GO:0098685]; serine-pyruvate aminotransferase complex [GO:0005969]	1-phosphatidylinositol binding [GO:0005545]; calmodulin binding [GO:0005516]; GTP-dependent protein binding [GO:0030742]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	axonal spine [GO:0044308]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; recycling endosome [GO:0055037]; Schaffer collateral - CA1 synapse [GO:0098685]; serine-pyruvate aminotransferase complex [GO:0005969]; 1-phosphatidylinositol binding [GO:0005545]; calmodulin binding [GO:0005516]; GTP-dependent protein binding [GO:0030742]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; chemical synaptic transmission, postsynaptic [GO:0099565]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; modulation by host of viral process [GO:0044788]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Q15077	reviewed	P2RY6_HUMAN	P2Y purinoceptor 6 (P2Y6)	P2RY6 PP2891	Homo sapiens (Human)	328	FUNCTION: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.		activation of phospholipase C activity [GO:0007202]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to purine-containing compound [GO:0071415]; cellular response to pyrimidine ribonucleotide [GO:1905835]; G protein-coupled receptor signaling pathway [GO:0007186]; phagocytosis [GO:0006909]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; transepithelial chloride transport [GO:0030321]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	G protein-coupled ADP receptor activity [GO:0001621]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled UDP receptor activity [GO:0045029]; G protein-coupled UTP receptor activity [GO:0045030]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; G protein-coupled ADP receptor activity [GO:0001621]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled UDP receptor activity [GO:0045029]; G protein-coupled UTP receptor activity [GO:0045030]; activation of phospholipase C activity [GO:0007202]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to purine-containing compound [GO:0071415]; cellular response to pyrimidine ribonucleotide [GO:1905835]; G protein-coupled receptor signaling pathway [GO:0007186]; phagocytosis [GO:0006909]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; transepithelial chloride transport [GO:0030321]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q15078	reviewed	CD5R1_HUMAN	Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]	CDK5R1 CDK5R NCK5A	Homo sapiens (Human)	307	FUNCTION: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:24235147}.	MISCELLANEOUS: Cleavage of p35 to p25 may be involved in the pathogenesis of cytoskeletal abnormalities and neuronal death in neurodegenerative diseases. The p25 form accumulates in neurons in the brain of patients with Alzheimer disease, but not in normal brain. This accumulation correlates with an increase in CDK5 kinase activity. Application of amyloid beta peptide A-beta(1-42) induced the conversion of p35 to p25 in primary cortical neurons. Expression of the p25/Cdk5 complex in cultured primary neurons induces cytoskeletal disruption, morphological degeneration and apoptosis.	axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; brain development [GO:0007420]; cerebellum development [GO:0021549]; embryo development ending in birth or egg hatching [GO:0009792]; ephrin receptor signaling pathway [GO:0048013]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G1 to G0 transition involved in cell differentiation [GO:0070315]; hippocampus development [GO:0021766]; ionotropic glutamate receptor signaling pathway [GO:0035235]; layer formation in cerebral cortex [GO:0021819]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of DNA-templated transcription [GO:0045892]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of macroautophagy [GO:0016241]; regulation of neuron differentiation [GO:0045664]; regulation of synaptic vesicle cycle [GO:0098693]; rhythmic process [GO:0048511]; superior olivary nucleus maturation [GO:0021722]	axon [GO:0030424]; contractile fiber [GO:0043292]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; protein kinase 5 complex [GO:0016533]	actin filament binding [GO:0051015]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; ephrin receptor binding [GO:0046875]; ionotropic glutamate receptor binding [GO:0035255]; kinase activity [GO:0016301]; protease binding [GO:0002020]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]	axon [GO:0030424]; contractile fiber [GO:0043292]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; protein kinase 5 complex [GO:0016533]; actin filament binding [GO:0051015]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; ephrin receptor binding [GO:0046875]; ionotropic glutamate receptor binding [GO:0035255]; kinase activity [GO:0016301]; protease binding [GO:0002020]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; brain development [GO:0007420]; cerebellum development [GO:0021549]; embryo development ending in birth or egg hatching [GO:0009792]; ephrin receptor signaling pathway [GO:0048013]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G1 to G0 transition involved in cell differentiation [GO:0070315]; hippocampus development [GO:0021766]; ionotropic glutamate receptor signaling pathway [GO:0035235]; layer formation in cerebral cortex [GO:0021819]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of DNA-templated transcription [GO:0045892]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of macroautophagy [GO:0016241]; regulation of neuron differentiation [GO:0045664]; regulation of synaptic vesicle cycle [GO:0098693]; rhythmic process [GO:0048511]; superior olivary nucleus maturation [GO:0021722]	SUBCELLULAR LOCATION: [Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane {ECO:0000305|PubMed:17671990}; Lipid-anchor {ECO:0000269|PubMed:18507738}; Cytoplasmic side {ECO:0000305}. Cell projection, neuron projection {ECO:0000269|PubMed:10604467}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. {ECO:0000269|PubMed:10604467}.; SUBCELLULAR LOCATION: [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus {ECO:0000269|PubMed:18507738}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10604467}. Perikaryon {ECO:0000269|PubMed:10604467}. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions (PubMed:18507738). In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites (PubMed:18507738). {ECO:0000269|PubMed:18507738}.
Q15080	reviewed	NCF4_HUMAN	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (SH3 and PX domain-containing protein 4) (p40-phox) (p40phox)	NCF4 SH3PXD4	Homo sapiens (Human)	339	FUNCTION: Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. {ECO:0000269|PubMed:8280052}.		phagocytosis [GO:0006909]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]	phosphatidylinositol-3-phosphate binding [GO:0032266]; superoxide-generating NADPH oxidase activator activity [GO:0016176]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]; phosphatidylinositol-3-phosphate binding [GO:0032266]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; phagocytosis [GO:0006909]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:8280052}. Endosome membrane {ECO:0000269|PubMed:11684018}; Peripheral membrane protein {ECO:0000269|PubMed:11684018}; Cytoplasmic side {ECO:0000269|PubMed:11684018}. Membrane {ECO:0000269|PubMed:11684018}; Peripheral membrane protein {ECO:0000269|PubMed:11684018}.
Q15084	reviewed	PDIA6_HUMAN	Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)	PDIA6 ERP5 P5 TXNDC7	Homo sapiens (Human)	440	FUNCTION: May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}.		protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; plasma membrane [GO:0005886]	protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15466936}. Cell membrane {ECO:0000269|PubMed:15466936}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12643545}.
Q15102	reviewed	PA1B3_HUMAN	Platelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma)	PAFAH1B3 PAFAHG	Homo sapiens (Human)	231	FUNCTION: Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain. {ECO:0000250|UniProtKB:Q29460}.	MISCELLANEOUS: Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (PubMed:7669037) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity). {ECO:0000250|UniProtKB:P43034, ECO:0000250|UniProtKB:P68402, ECO:0000250|UniProtKB:Q29460, ECO:0000303|PubMed:7669037}.	lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; nervous system development [GO:0007399]; spermatogenesis [GO:0007283]	1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; identical protein binding [GO:0042802]; platelet-activating factor acetyltransferase activity [GO:0047179]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; identical protein binding [GO:0042802]; platelet-activating factor acetyltransferase activity [GO:0047179]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; nervous system development [GO:0007399]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm.
Q15109	reviewed	RAGE_HUMAN	Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)	AGER RAGE	Homo sapiens (Human)	404	FUNCTION: Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans (PubMed:27572515, PubMed:28515150, PubMed:34743181). Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes (PubMed:21565706). These ligands accumulate at inflammatory sites during the pathogenesis of various diseases, including diabetes, vascular complications, neurodegenerative disorders, and cancers and RAGE transduces their binding into pro-inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction or inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B (PubMed:21829704). Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (PubMed:19386136). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons (PubMed:19906677). ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability (PubMed:27572515). Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome (PubMed:34743181). Promotes also extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (PubMed:24081950, PubMed:28515150). {ECO:0000250|UniProtKB:Q62151, ECO:0000269|PubMed:19906677, ECO:0000269|PubMed:20943659, ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:21565706, ECO:0000269|PubMed:21829704, ECO:0000269|PubMed:24081950, ECO:0000269|PubMed:27572515, ECO:0000269|PubMed:28515150, ECO:0000269|PubMed:34743181}.	MISCELLANEOUS: [Isoform 10]: Detected in lung, brain, heart and kidney. {ECO:0000305}.	astrocyte activation [GO:0048143]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; glucose mediated signaling pathway [GO:0010255]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; learning or memory [GO:0007611]; microglial cell activation [GO:0001774]; negative regulation of blood circulation [GO:1903523]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of long-term synaptic potentiation [GO:1900272]; neuron projection development [GO:0031175]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of chemokine production [GO:0032722]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of endothelin production [GO:1904472]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of tumor necrosis factor production [GO:0032760]; protein localization to membrane [GO:0072657]; regulation of CD4-positive, alpha-beta T cell activation [GO:2000514]; regulation of inflammatory response [GO:0050727]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of p38MAPK cascade [GO:1900744]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synaptic plasticity [GO:0048167]; regulation of T cell mediated cytotoxicity [GO:0001914]; response to amyloid-beta [GO:1904645]; response to hypoxia [GO:0001666]; response to wounding [GO:0009611]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell surface [GO:0009986]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	advanced glycation end-product receptor activity [GO:0050785]; amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; laminin receptor activity [GO:0005055]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; S100 protein binding [GO:0044548]; scavenger receptor activity [GO:0005044]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell surface [GO:0009986]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; advanced glycation end-product receptor activity [GO:0050785]; amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; laminin receptor activity [GO:0005055]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; S100 protein binding [GO:0044548]; scavenger receptor activity [GO:0005044]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; astrocyte activation [GO:0048143]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; glucose mediated signaling pathway [GO:0010255]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; learning or memory [GO:0007611]; microglial cell activation [GO:0001774]; negative regulation of blood circulation [GO:1903523]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of long-term synaptic potentiation [GO:1900272]; neuron projection development [GO:0031175]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of chemokine production [GO:0032722]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of endothelin production [GO:1904472]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of tumor necrosis factor production [GO:0032760]; protein localization to membrane [GO:0072657]; regulation of CD4-positive, alpha-beta T cell activation [GO:2000514]; regulation of inflammatory response [GO:0050727]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of p38MAPK cascade [GO:1900744]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synaptic plasticity [GO:0048167]; regulation of T cell mediated cytotoxicity [GO:0001914]; response to amyloid-beta [GO:1904645]; response to hypoxia [GO:0001666]; response to wounding [GO:0009611]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:24081950, ECO:0000269|PubMed:27572515}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 10]: Cell membrane {ECO:0000269|PubMed:24260107}; Single-pass type I membrane protein {ECO:0000269|PubMed:24260107}.
Q15111	reviewed	PLCL1_HUMAN	Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP)	PLCL1	Homo sapiens (Human)	1095	FUNCTION: Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. {ECO:0000250, ECO:0000269|PubMed:17254016}.		gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of synaptic transmission, GABAergic [GO:0032228]	cytoplasm [GO:0005737]	phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]	cytoplasm [GO:0005737]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of synaptic transmission, GABAergic [GO:0032228]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q15113	reviewed	PCOC1_HUMAN	Procollagen C-endopeptidase enhancer 1 (Procollagen COOH-terminal proteinase enhancer 1) (PCPE-1) (Procollagen C-proteinase enhancer 1) (Type 1 procollagen C-proteinase enhancer protein) (Type I procollagen COOH-terminal proteinase enhancer)	PCOLCE PCPE1	Homo sapiens (Human)	449	FUNCTION: Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.; FUNCTION: C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.		collagen biosynthetic process [GO:0032964]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	collagen binding [GO:0005518]; heparin binding [GO:0008201]; peptidase activator activity [GO:0016504]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; collagen binding [GO:0005518]; heparin binding [GO:0008201]; peptidase activator activity [GO:0016504]; collagen biosynthetic process [GO:0032964]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
Q15116	reviewed	PDCD1_HUMAN	Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)	PDCD1 PD1	Homo sapiens (Human)	288	FUNCTION: Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity). {ECO:0000250|UniProtKB:Q02242, ECO:0000269|PubMed:21276005}.; FUNCTION: The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28951311). The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:28951311). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:22658127, PubMed:25034862, PubMed:25399552). {ECO:0000269|PubMed:22658127, ECO:0000269|PubMed:25034862, ECO:0000269|PubMed:25399552, ECO:0000303|PubMed:28951311}.		adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell apoptotic process [GO:0001783]; humoral immune response [GO:0006959]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of immune response [GO:0050777]; negative regulation of tolerance induction [GO:0002644]; positive regulation of T cell apoptotic process [GO:0070234]; regulation of immune response [GO:0050776]; regulatory T cell apoptotic process [GO:1902482]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]		external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell apoptotic process [GO:0001783]; humoral immune response [GO:0006959]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of immune response [GO:0050777]; negative regulation of tolerance induction [GO:0002644]; positive regulation of T cell apoptotic process [GO:0070234]; regulation of immune response [GO:0050776]; regulatory T cell apoptotic process [GO:1902482]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30487606}; Single-pass type I membrane protein.
Q15118	reviewed	PDK1_HUMAN	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)	PDK1 PDHK1	Homo sapiens (Human)	436	FUNCTION: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:7499431}.	MISCELLANEOUS: Exposure of cancer cells to severe hypoxia induces translocation of AKT to the mitochondrion, leading to AKT-mediated phosphorylation of PDK1 at Thr-346 which supports tumor cell survival and proliferation during hypoxia. {ECO:0000269|PubMed:27505672}.	cell population proliferation [GO:0008283]; glucose metabolic process [GO:0006006]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; phosphorylation [GO:0016310]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of glucose metabolic process [GO:0010906]	mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740]	mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740]; cell population proliferation [GO:0008283]; glucose metabolic process [GO:0006006]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; phosphorylation [GO:0016310]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of glucose metabolic process [GO:0010906]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:22195962}.
Q15119	reviewed	PDK2_HUMAN	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)	PDK2 PDHK2	Homo sapiens (Human)	407	FUNCTION: Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. {ECO:0000269|PubMed:17222789, ECO:0000269|PubMed:19833728, ECO:0000269|PubMed:21283817, ECO:0000269|PubMed:22123926, ECO:0000269|PubMed:7499431, ECO:0000269|PubMed:9787110}.		cellular response to nutrient [GO:0031670]; cellular response to reactive oxygen species [GO:0034614]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; phosphorylation [GO:0016310]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cellular ketone metabolic process [GO:0010565]; regulation of gluconeogenesis [GO:0006111]; regulation of glucose metabolic process [GO:0010906]; regulation of pH [GO:0006885]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740]; cellular response to nutrient [GO:0031670]; cellular response to reactive oxygen species [GO:0034614]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; phosphorylation [GO:0016310]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cellular ketone metabolic process [GO:0010565]; regulation of gluconeogenesis [GO:0006111]; regulation of glucose metabolic process [GO:0010906]; regulation of pH [GO:0006885]	SUBCELLULAR LOCATION: Mitochondrion matrix.
Q15120	reviewed	PDK3_HUMAN	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	PDK3 PDHK3	Homo sapiens (Human)	406	FUNCTION: Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. {ECO:0000269|PubMed:10748134, ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:16436377, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18718909, ECO:0000269|PubMed:22865452}.		cellular response to fatty acid [GO:0071398]; cellular response to glucose stimulus [GO:0071333]; glucose metabolic process [GO:0006006]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; peptidyl-serine phosphorylation [GO:0018105]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of glucose metabolic process [GO:0010906]; regulation of reactive oxygen species metabolic process [GO:2000377]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740]; cellular response to fatty acid [GO:0071398]; cellular response to glucose stimulus [GO:0071333]; glucose metabolic process [GO:0006006]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; peptidyl-serine phosphorylation [GO:0018105]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of glucose metabolic process [GO:0010906]; regulation of reactive oxygen species metabolic process [GO:2000377]	SUBCELLULAR LOCATION: Mitochondrion matrix.
Q15121	reviewed	PEA15_HUMAN	Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED)	PEA15	Homo sapiens (Human)	130	FUNCTION: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. {ECO:0000250, ECO:0000269|PubMed:10442631, ECO:0000269|PubMed:9670003}.		apoptotic process [GO:0006915]; carbohydrate transport [GO:0008643]; MAPK cascade [GO:0000165]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of glucose import [GO:0046325]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]; apoptotic process [GO:0006915]; carbohydrate transport [GO:0008643]; MAPK cascade [GO:0000165]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of glucose import [GO:0046325]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]	SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with microtubules.
Q15124	reviewed	PGM5_HUMAN	Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP)	PGM5 PGMRP	Homo sapiens (Human)	567	FUNCTION: Component of adherens-type cell-cell and cell-matrix junctions (PubMed:8175905). Has no phosphoglucomutase activity in vitro (PubMed:8175905). {ECO:0000269|PubMed:8175905}.		carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; myofibril assembly [GO:0030239]; striated muscle tissue development [GO:0014706]	adherens junction [GO:0005912]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; sarcolemma [GO:0042383]; spot adherens junction [GO:0005914]; stress fiber [GO:0001725]; Z disc [GO:0030018]	intramolecular transferase activity, phosphotransferases [GO:0016868]; magnesium ion binding [GO:0000287]; structural molecule activity [GO:0005198]	adherens junction [GO:0005912]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; sarcolemma [GO:0042383]; spot adherens junction [GO:0005914]; stress fiber [GO:0001725]; Z disc [GO:0030018]; intramolecular transferase activity, phosphotransferases [GO:0016868]; magnesium ion binding [GO:0000287]; structural molecule activity [GO:0005198]; carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; myofibril assembly [GO:0030239]; striated muscle tissue development [GO:0014706]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:8175905}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8175905}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q8BZF8}. Note=Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments. {ECO:0000269|PubMed:8175905}.
Q15125	reviewed	EBP_HUMAN	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein)	EBP	Homo sapiens (Human)	230	FUNCTION: Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. {ECO:0000269|PubMed:12760743, ECO:0000269|PubMed:8798407, ECO:0000269|PubMed:9894009}.	MISCELLANEOUS: Binds to the phenylalkylamine calcium-ion antagonist emopamil, an anti-ischemic drug.	cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; cholesterol metabolic process [GO:0008203]; hemopoiesis [GO:0030097]; ossification involved in bone maturation [GO:0043931]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]	C-8 sterol isomerase activity [GO:0000247]; cholestenol delta-isomerase activity [GO:0047750]; identical protein binding [GO:0042802]; steroid delta-isomerase activity [GO:0004769]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; C-8 sterol isomerase activity [GO:0000247]; cholestenol delta-isomerase activity [GO:0047750]; identical protein binding [GO:0042802]; steroid delta-isomerase activity [GO:0004769]; cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; cholesterol metabolic process [GO:0008203]; hemopoiesis [GO:0030097]; ossification involved in bone maturation [GO:0043931]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10406945}; Multi-pass membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000269|PubMed:10406945}. Cytoplasmic vesicle {ECO:0000269|PubMed:10406945}. Note=During interphase, detected on the endoplasmic reticulum and the nuclear envelope. During mitosis, detected on cytoplasmic vesicles. {ECO:0000269|PubMed:10406945}.
Q15126	reviewed	PMVK_HUMAN	Phosphomevalonate kinase (PMKase) (hPMK) (EC 2.7.4.2)	PMVK PMKI	Homo sapiens (Human)	192	FUNCTION: Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites. {ECO:0000269|PubMed:16519518, ECO:0000269|PubMed:17902708, ECO:0000269|PubMed:8663599, ECO:0000269|PubMed:9392419}.		cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; phosphorylation [GO:0016310]; response to cholesterol [GO:0070723]; sterol biosynthetic process [GO:0016126]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; peroxisome [GO:0005777]	ATP binding [GO:0005524]; phosphomevalonate kinase activity [GO:0004631]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; peroxisome [GO:0005777]; ATP binding [GO:0005524]; phosphomevalonate kinase activity [GO:0004631]; cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; phosphorylation [GO:0016310]; response to cholesterol [GO:0070723]; sterol biosynthetic process [GO:0016126]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10191291, ECO:0000269|PubMed:27052676}.
Q15131	reviewed	CDK10_HUMAN	Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) (Serine/threonine-protein kinase PISSLRE)	CDK10	Homo sapiens (Human)	360	FUNCTION: Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747). {ECO:0000269|PubMed:24218572, ECO:0000269|PubMed:27104747}.		cell projection organization [GO:0030030]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cilium assembly [GO:1902018]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of MAPK cascade [GO:0043410]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of mitotic cell cycle [GO:0007346]; traversing start control point of mitotic cell cycle [GO:0007089]	ciliary basal body [GO:0036064]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ciliary basal body [GO:0036064]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell projection organization [GO:0030030]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cilium assembly [GO:1902018]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of MAPK cascade [GO:0043410]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of mitotic cell cycle [GO:0007346]; traversing start control point of mitotic cell cycle [GO:0007089]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27104747}.
Q15139	reviewed	KPCD1_HUMAN	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)	PRKD1 PKD PKD1 PRKCM	Homo sapiens (Human)	912	FUNCTION: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}.		angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to amino acid starvation [GO:0034198]; cellular response to angiotensin [GO:1904385]; cellular response to endothelin [GO:1990859]; cellular response to hydroperoxide [GO:0071447]; cellular response to norepinephrine stimulus [GO:0071874]; cellular response to oxidative stress [GO:0034599]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; defense response to Gram-negative bacterium [GO:0050829]; Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; negative regulation of endocytosis [GO:0045806]; nervous system development [GO:0007399]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell size [GO:0045793]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; protein kinase D signaling [GO:0089700]; regulation of integrin-mediated signaling pathway [GO:2001044]; regulation of keratinocyte proliferation [GO:0010837]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril [GO:0014723]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	autophagosome membrane [GO:0000421]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; Z disc [GO:0030018]	ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase C activity [GO:0004697]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	autophagosome membrane [GO:0000421]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; Z disc [GO:0030018]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase C activity [GO:0004697]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to amino acid starvation [GO:0034198]; cellular response to angiotensin [GO:1904385]; cellular response to endothelin [GO:1990859]; cellular response to hydroperoxide [GO:0071447]; cellular response to norepinephrine stimulus [GO:0071874]; cellular response to oxidative stress [GO:0034599]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; defense response to Gram-negative bacterium [GO:0050829]; Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; negative regulation of endocytosis [GO:0045806]; nervous system development [GO:0007399]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell size [GO:0045793]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; protein kinase D signaling [GO:0089700]; regulation of integrin-mediated signaling pathway [GO:2001044]; regulation of keratinocyte proliferation [GO:0010837]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril [GO:0014723]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18076381}. Cell membrane {ECO:0000269|PubMed:18076381}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q62101}. Note=Translocation to the cell membrane is required for kinase activation.
Q15147	reviewed	PLCB4_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)	PLCB4	Homo sapiens (Human)	1175	FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. {ECO:0000250|UniProtKB:Q07722}.		G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol-mediated signaling [GO:0048015]; release of sequestered calcium ion into cytosol [GO:0051209]	cytosol [GO:0005829]	calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]	cytosol [GO:0005829]; calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol-mediated signaling [GO:0048015]; release of sequestered calcium ion into cytosol [GO:0051209]	
Q15149	reviewed	PLEC_HUMAN	Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)	PLEC PLEC1	Homo sapiens (Human)	4684	FUNCTION: Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.		actomyosin contractile ring assembly actin filament organization [GO:2000689]; adherens junction organization [GO:0034332]; cardiac muscle cell development [GO:0055013]; cell morphogenesis [GO:0000902]; cellular response to extracellular stimulus [GO:0031668]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to mechanical stimulus [GO:0071260]; establishment of skin barrier [GO:0061436]; fibroblast migration [GO:0010761]; gene expression [GO:0010467]; hemidesmosome assembly [GO:0031581]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte development [GO:0003334]; leukocyte migration involved in immune response [GO:0002522]; mitochondrion morphogenesis [GO:0070584]; multicellular organism growth [GO:0035264]; myoblast differentiation [GO:0045445]; nucleus organization [GO:0006997]; peripheral nervous system myelin maintenance [GO:0032287]; protein localization [GO:0008104]; protein-containing complex organization [GO:0043933]; regulation of vascular permeability [GO:0043114]; respiratory electron transport chain [GO:0022904]; response to food [GO:0032094]; sarcomere organization [GO:0045214]; skeletal muscle fiber development [GO:0048741]; skeletal myofibril assembly [GO:0014866]; T cell chemotaxis [GO:0010818]; tight junction organization [GO:0120193]; transmission of nerve impulse [GO:0019226]; wound healing [GO:0042060]	axon [GO:0030424]; brush border [GO:0005903]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; mitochondrial outer membrane [GO:0005741]; myelin sheath [GO:0043209]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; dystroglycan binding [GO:0002162]; protein self-association [GO:0043621]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]	axon [GO:0030424]; brush border [GO:0005903]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; mitochondrial outer membrane [GO:0005741]; myelin sheath [GO:0043209]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; dystroglycan binding [GO:0002162]; protein self-association [GO:0043621]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; actomyosin contractile ring assembly actin filament organization [GO:2000689]; adherens junction organization [GO:0034332]; cardiac muscle cell development [GO:0055013]; cell morphogenesis [GO:0000902]; cellular response to extracellular stimulus [GO:0031668]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to mechanical stimulus [GO:0071260]; establishment of skin barrier [GO:0061436]; fibroblast migration [GO:0010761]; gene expression [GO:0010467]; hemidesmosome assembly [GO:0031581]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte development [GO:0003334]; leukocyte migration involved in immune response [GO:0002522]; mitochondrion morphogenesis [GO:0070584]; multicellular organism growth [GO:0035264]; myoblast differentiation [GO:0045445]; nucleus organization [GO:0006997]; peripheral nervous system myelin maintenance [GO:0032287]; protein localization [GO:0008104]; protein-containing complex organization [GO:0043933]; regulation of vascular permeability [GO:0043114]; respiratory electron transport chain [GO:0022904]; response to food [GO:0032094]; sarcomere organization [GO:0045214]; skeletal muscle fiber development [GO:0048741]; skeletal myofibril assembly [GO:0014866]; T cell chemotaxis [GO:0010818]; tight junction organization [GO:0120193]; transmission of nerve impulse [GO:0019226]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12482924}. Cell junction, hemidesmosome {ECO:0000269|PubMed:12482924}.
Q15154	reviewed	PCM1_HUMAN	Pericentriolar material 1 protein (PCM-1) (hPCM-1)	PCM1	Homo sapiens (Human)	2024	FUNCTION: Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubMed:24121310, PubMed:27979967). Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites (PubMed:34782749). {ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:15659651, ECO:0000269|PubMed:16943179, ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:34782749}.		centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; interkinetic nuclear migration [GO:0022027]; intraciliary transport involved in cilium assembly [GO:0035735]; microtubule anchoring [GO:0034453]; microtubule anchoring at centrosome [GO:0034454]; negative regulation of neurogenesis [GO:0050768]; neuron migration [GO:0001764]; neuronal stem cell population maintenance [GO:0097150]; non-motile cilium assembly [GO:1905515]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539]; protein-containing complex localization to centriolar satellite [GO:0140706]; regulation of protein complex stability [GO:0061635]; social behavior [GO:0035176]	apical part of cell [GO:0045177]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]	apical part of cell [GO:0045177]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; interkinetic nuclear migration [GO:0022027]; intraciliary transport involved in cilium assembly [GO:0035735]; microtubule anchoring [GO:0034453]; microtubule anchoring at centrosome [GO:0034454]; negative regulation of neurogenesis [GO:0050768]; neuron migration [GO:0001764]; neuronal stem cell population maintenance [GO:0097150]; non-motile cilium assembly [GO:1905515]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539]; protein-containing complex localization to centriolar satellite [GO:0140706]; regulation of protein complex stability [GO:0061635]; social behavior [GO:0035176]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8AV28}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20719959, ECO:0000269|PubMed:30804208}. Cytoplasmic granule {ECO:0000269|PubMed:15107855}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:15107855, ECO:0000269|PubMed:20719959, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:34782749}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24121310}. Note=Recruitment to the centrosome requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. Displaced from centriolar satellites and centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling.
Q15155	reviewed	NOMO1_HUMAN	BOS complex subunit NOMO1 (Nodal modulator 1) (pM5 protein)	NOMO1 PM5	Homo sapiens (Human)	1222	FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261522, PubMed:32820719). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). {ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.		multi-pass transmembrane protein insertion into ER membrane [GO:0160063]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; multi-pass translocon complex [GO:0160064]	carbohydrate binding [GO:0030246]; ribosome binding [GO:0043022]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; multi-pass translocon complex [GO:0160064]; carbohydrate binding [GO:0030246]; ribosome binding [GO:0043022]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17261586, ECO:0000269|PubMed:36261522}; Single-pass type I membrane protein {ECO:0000305}.
Q15165	reviewed	PON2_HUMAN	Serum paraoxonase/arylesterase 2 (PON 2) (EC 3.1.1.2) (EC 3.1.1.81) (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2)	PON2	Homo sapiens (Human)	354	FUNCTION: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. {ECO:0000269|PubMed:11579088, ECO:0000269|PubMed:15772423}.		aromatic compound catabolic process [GO:0019439]; response to toxic substance [GO:0009636]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; arylesterase activity [GO:0004064]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; arylesterase activity [GO:0004064]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; aromatic compound catabolic process [GO:0019439]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11579088}; Peripheral membrane protein {ECO:0000269|PubMed:11579088}.
Q15166	reviewed	PON3_HUMAN	Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1)	PON3	Homo sapiens (Human)	354	FUNCTION: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. {ECO:0000269|PubMed:15772423}.		aromatic compound catabolic process [GO:0019439]; carboxylic acid catabolic process [GO:0046395]; establishment of localization in cell [GO:0051649]; negative regulation of superoxide anion generation [GO:0032929]; renal sodium ion transport [GO:0003096]; response to toxic substance [GO:0009636]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; aryldialkylphosphatase activity [GO:0004063]; arylesterase activity [GO:0004064]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; aryldialkylphosphatase activity [GO:0004063]; arylesterase activity [GO:0004064]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; aromatic compound catabolic process [GO:0019439]; carboxylic acid catabolic process [GO:0046395]; establishment of localization in cell [GO:0051649]; negative regulation of superoxide anion generation [GO:0032929]; renal sodium ion transport [GO:0003096]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
Q15170	reviewed	TCAL1_HUMAN	Transcription elongation factor A protein-like 1 (TCEA-like protein 1) (Nuclear phosphoprotein p21/SIIR) (Transcription elongation factor S-II protein-like 1)	TCEAL1 SIIR	Homo sapiens (Human)	159	FUNCTION: May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.			nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus.
Q15172	reviewed	2A5A_HUMAN	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha)	PPP2R5A	Homo sapiens (Human)	486	FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.		negative regulation of lipid kinase activity [GO:0090219]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of protein dephosphorylation [GO:0035307]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; M band [GO:0031430]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 2A complex [GO:0000159]; Z disc [GO:0030018]	kinase binding [GO:0019900]; phosphoprotein phosphatase activity [GO:0004721]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]	centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; M band [GO:0031430]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 2A complex [GO:0000159]; Z disc [GO:0030018]; kinase binding [GO:0019900]; phosphoprotein phosphatase activity [GO:0004721]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]; negative regulation of lipid kinase activity [GO:0090219]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of protein dephosphorylation [GO:0035307]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8703017}. Nucleus {ECO:0000269|PubMed:8703017}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase. {ECO:0000269|PubMed:16541025}.
Q15173	reviewed	2A5B_HUMAN	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta)	PPP2R5B	Homo sapiens (Human)	497	FUNCTION: As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. {ECO:0000269|PubMed:21329884}.		cellular response to growth factor stimulus [GO:0071363]; negative regulation of G0 to G1 transition [GO:0070317]; positive regulation of neuron projection development [GO:0010976]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of protein autophosphorylation [GO:0031952]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]; cellular response to growth factor stimulus [GO:0071363]; negative regulation of G0 to G1 transition [GO:0070317]; positive regulation of neuron projection development [GO:0010976]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of protein autophosphorylation [GO:0031952]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8703017}.
Q15185	reviewed	TEBP_HUMAN	Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23)	PTGES3 P23 TEBP	Homo sapiens (Human)	160	FUNCTION: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}.		chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein complex assembly [GO:0051131]; cyclooxygenase pathway [GO:0019371]; fibroblast proliferation [GO:0048144]; glucocorticoid receptor signaling pathway [GO:0042921]; glycogen biosynthetic process [GO:0005978]; lung saccule development [GO:0060430]; positive regulation of phosphorylation [GO:0042327]; positive regulation of telomerase activity [GO:0051973]; prostaglandin biosynthetic process [GO:0001516]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; signal transduction [GO:0007165]; skin development [GO:0043588]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; telomerase holoenzyme complex [GO:0005697]	DNA polymerase binding [GO:0070182]; Hsp90 protein binding [GO:0051879]; prostaglandin-E synthase activity [GO:0050220]; protein-folding chaperone binding [GO:0051087]; telomerase activity [GO:0003720]; unfolded protein binding [GO:0051082]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; telomerase holoenzyme complex [GO:0005697]; DNA polymerase binding [GO:0070182]; Hsp90 protein binding [GO:0051879]; prostaglandin-E synthase activity [GO:0050220]; protein-folding chaperone binding [GO:0051087]; telomerase activity [GO:0003720]; unfolded protein binding [GO:0051082]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein complex assembly [GO:0051131]; cyclooxygenase pathway [GO:0019371]; fibroblast proliferation [GO:0048144]; glucocorticoid receptor signaling pathway [GO:0042921]; glycogen biosynthetic process [GO:0005978]; lung saccule development [GO:0060430]; positive regulation of phosphorylation [GO:0042327]; positive regulation of telomerase activity [GO:0051973]; prostaglandin biosynthetic process [GO:0001516]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; signal transduction [GO:0007165]; skin development [GO:0043588]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3ZBF7}.
Q15208	reviewed	STK38_HUMAN	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)	STK38 NDR1	Homo sapiens (Human)	465	FUNCTION: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:7761441}.		intracellular signal transduction [GO:0035556]; negative regulation of MAP kinase activity [GO:0043407]; postsynapse organization [GO:0099173]; protein modification process [GO:0036211]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; magnesium ion binding [GO:0000287]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; magnesium ion binding [GO:0000287]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; negative regulation of MAP kinase activity [GO:0043407]; postsynapse organization [GO:0099173]; protein modification process [GO:0036211]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
Q15223	reviewed	NECT1_HUMAN	Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111)	NECTIN1 HVEC PRR1 PVRL1	Homo sapiens (Human)	517	FUNCTION: Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity. {ECO:0000269|PubMed:21980294}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV. {ECO:0000269|PubMed:7721102, ECO:0000269|PubMed:9657005}.		axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; enamel mineralization [GO:0070166]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune response [GO:0006955]; iron ion transport [GO:0006826]; lens morphogenesis in camera-type eye [GO:0002089]; protein localization to cell junction [GO:1902414]; regulation of synapse assembly [GO:0051963]; retina development in camera-type eye [GO:0060041]; viral entry into host cell [GO:0046718]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; cell-cell contact zone [GO:0044291]; dendrite [GO:0030425]; extracellular region [GO:0005576]; growth cone membrane [GO:0032584]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]	carbohydrate binding [GO:0030246]; cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; virion binding [GO:0046790]; virus receptor activity [GO:0001618]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; cell-cell contact zone [GO:0044291]; dendrite [GO:0030425]; extracellular region [GO:0005576]; growth cone membrane [GO:0032584]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; carbohydrate binding [GO:0030246]; cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; virion binding [GO:0046790]; virus receptor activity [GO:0001618]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; enamel mineralization [GO:0070166]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune response [GO:0006955]; iron ion transport [GO:0006826]; lens morphogenesis in camera-type eye [GO:0002089]; protein localization to cell junction [GO:1902414]; regulation of synapse assembly [GO:0051963]; retina development in camera-type eye [GO:0060041]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein. Presynaptic cell membrane {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform Delta]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Gamma]: Secreted.
Q15233	reviewed	NONO_HUMAN	Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)	NONO NRB54	Homo sapiens (Human)	471	FUNCTION: DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}.		activation of innate immune response [GO:0002218]; cellular response to angiotensin [GO:1904385]; cellular response to oxygen-glucose deprivation [GO:0090650]; circadian rhythm [GO:0007623]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; RNA splicing [GO:0008380]	chromosome [GO:0005694]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; RNA binding [GO:0003723]	chromosome [GO:0005694]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; RNA binding [GO:0003723]; activation of innate immune response [GO:0002218]; cellular response to angiotensin [GO:1904385]; cellular response to oxygen-glucose deprivation [GO:0090650]; circadian rhythm [GO:0007623]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}. Nucleus, nucleolus. Nucleus speckle {ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}. Chromosome {ECO:0000250|UniProtKB:Q99K48}. Note=Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. {ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}.
Q15256	reviewed	PTPRR_HUMAN	Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1)	PTPRR ECPTP PTPRQ	Homo sapiens (Human)	657	FUNCTION: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity). {ECO:0000250}.		ERBB2 signaling pathway [GO:0038128]; in utero embryonic development [GO:0001701]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; ERBB2 signaling pathway [GO:0038128]; in utero embryonic development [GO:0001701]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25326458}.; SUBCELLULAR LOCATION: [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Delta]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.; SUBCELLULAR LOCATION: [Isoform Gamma]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.
Q15257	reviewed	PTPA_HUMAN	Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')	PTPA PPP2R4	Homo sapiens (Human)	358	FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A. {ECO:0000250, ECO:0000269|PubMed:16916641, ECO:0000269|PubMed:17333320}.		mitotic spindle organization [GO:0007052]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of apoptotic process [GO:0043065]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of phosphoprotein phosphatase activity [GO:0043666]	ATPase complex [GO:1904949]; calcium channel complex [GO:0034704]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	ATP binding [GO:0005524]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888]; protein tyrosine phosphatase activator activity [GO:0008160]; signaling receptor binding [GO:0005102]	ATPase complex [GO:1904949]; calcium channel complex [GO:0034704]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]; ATP binding [GO:0005524]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888]; protein tyrosine phosphatase activator activity [GO:0008160]; signaling receptor binding [GO:0005102]; mitotic spindle organization [GO:0007052]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of apoptotic process [GO:0043065]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of phosphoprotein phosphatase activity [GO:0043666]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17333320}. Nucleus {ECO:0000269|PubMed:17333320}.
Q15262	reviewed	PTPRK_HUMAN	Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)	PTPRK PTPK	Homo sapiens (Human)	1439	FUNCTION: Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. {ECO:0000269|PubMed:19836242}.		cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; intracellular membrane-bounded organelle [GO:0043231]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; plasma membrane [GO:0005886]	beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; intracellular membrane-bounded organelle [GO:0043231]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.
Q15269	reviewed	PWP2_HUMAN	Periodic tryptophan protein 2 homolog	PWP2 PWP2H	Homo sapiens (Human)	919	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}.		maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]	nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:34516797}.
Q15274	reviewed	NADC_HUMAN	Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase)	QPRT	Homo sapiens (Human)	297	FUNCTION: Involved in the catabolism of quinolinic acid (QA). {ECO:0000269|PubMed:17868694, ECO:0000269|PubMed:24038671, ECO:0000269|PubMed:9473669}.		NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674]; quinolinate catabolic process [GO:0034213]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	identical protein binding [GO:0042802]; nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; identical protein binding [GO:0042802]; nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514]; NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674]; quinolinate catabolic process [GO:0034213]	
Q15276	reviewed	RABE1_HUMAN	Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17)	RABEP1 RAB5EP RABPT5 RABPT5A	Homo sapiens (Human)	862	FUNCTION: Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}.		apoptotic process [GO:0006915]; endocytosis [GO:0006897]; Golgi to plasma membrane transport [GO:0006893]; membrane fusion [GO:0061025]; protein localization to ciliary membrane [GO:1903441]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]	growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; apoptotic process [GO:0006915]; endocytosis [GO:0006897]; Golgi to plasma membrane transport [GO:0006893]; membrane fusion [GO:0061025]; protein localization to ciliary membrane [GO:1903441]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle.
Q15286	reviewed	RAB35_HUMAN	Ras-related protein Rab-35 (GTP-binding protein RAY) (Ras-related protein Rab-1C)	RAB35 RAB1C RAY	Homo sapiens (Human)	201	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. {ECO:0000250|UniProtKB:Q6PHN9, ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725}.		antigen processing and presentation [GO:0019882]; cellular response to nerve growth factor stimulus [GO:1990090]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; mitotic cytokinesis [GO:0000281]; neuron projection development [GO:0031175]; plasma membrane to endosome transport [GO:0048227]; protein localization [GO:0008104]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]	cell projection membrane [GO:0031253]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cell projection membrane [GO:0031253]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; antigen processing and presentation [GO:0019882]; cellular response to nerve growth factor stimulus [GO:1990090]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; mitotic cytokinesis [GO:0000281]; neuron projection development [GO:0031175]; plasma membrane to endosome transport [GO:0048227]; protein localization [GO:0008104]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:16950109}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:16950109}. Endosome {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Present on sorting endosomes and recycling endosome tubules (PubMed:16950109). Tends to be enriched in PIP2-positive cell membrane domains (PubMed:16950109). During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis (PubMed:16950109). Identified in stage I to stage IV melanosomes (PubMed:17081065). {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:17081065}.
Q15287	reviewed	RNPS1_HUMAN	RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)	RNPS1 LDC2	Homo sapiens (Human)	305	FUNCTION: Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions. {ECO:0000269|PubMed:10449421, ECO:0000269|PubMed:11546874, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:14729963, ECO:0000269|PubMed:14752011, ECO:0000269|PubMed:15684395, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:17586820, ECO:0000269|PubMed:22203037}.		DNA-templated transcription [GO:0006351]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	ASAP complex [GO:0061574]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]	ASAP complex [GO:0061574]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; DNA-templated transcription [GO:0006351]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
Q15291	reviewed	RBBP5_HUMAN	Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)	RBBP5 RBQ3	Homo sapiens (Human)	538	FUNCTION: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). Does not affect ES cell self-renewal (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:22266653, PubMed:21220120). {ECO:0000250|UniProtKB:Q8BX09, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.		DNA damage response [GO:0006974]; response to estrogen [GO:0043627]; transcription initiation-coupled chromatin remodeling [GO:0045815]	histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]	histone binding [GO:0042393]; transcription cis-regulatory region binding [GO:0000976]	histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]; histone binding [GO:0042393]; transcription cis-regulatory region binding [GO:0000976]; DNA damage response [GO:0006974]; response to estrogen [GO:0043627]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17355966}.
Q15293	reviewed	RCN1_HUMAN	Reticulocalbin-1	RCN1 RCN	Homo sapiens (Human)	331	FUNCTION: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.	MISCELLANEOUS: This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium. {ECO:0000250}.	camera-type eye development [GO:0043010]; in utero embryonic development [GO:0001701]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	calcium ion binding [GO:0005509]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; calcium ion binding [GO:0005509]; camera-type eye development [GO:0043010]; in utero embryonic development [GO:0001701]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
Q15303	reviewed	ERBB4_HUMAN	Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]	ERBB4 HER4	Homo sapiens (Human)	1308	FUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}.	MISCELLANEOUS: [Isoform JM-A CYT-1]: Proteolytical processing generates E4ICD1 (s80Cyt1).; MISCELLANEOUS: [Isoform JM-A CYT-2]: Proteolytical processing generates E4ICD2 (s80Cyt2). {ECO:0000305}.	cardiac muscle tissue regeneration [GO:0061026]; cell fate commitment [GO:0045165]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; central nervous system morphogenesis [GO:0021551]; embryonic pattern specification [GO:0009880]; ERBB2-ERBB4 signaling pathway [GO:0038135]; ERBB4 signaling pathway [GO:0038130]; ERBB4-ERBB4 signaling pathway [GO:0038138]; establishment of planar polarity involved in nephron morphogenesis [GO:0072046]; heart development [GO:0007507]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell differentiation [GO:0060644]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neurogenesis [GO:0022008]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; olfactory bulb interneuron differentiation [GO:0021889]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; epidermal growth factor receptor activity [GO:0005006]; epidermal growth factor receptor binding [GO:0005154]; GABA receptor binding [GO:0050811]; neuregulin receptor activity [GO:0038131]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; transcription cis-regulatory region binding [GO:0000976]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; epidermal growth factor receptor activity [GO:0005006]; epidermal growth factor receptor binding [GO:0005154]; GABA receptor binding [GO:0050811]; neuregulin receptor activity [GO:0038131]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; transcription cis-regulatory region binding [GO:0000976]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; cardiac muscle tissue regeneration [GO:0061026]; cell fate commitment [GO:0045165]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; central nervous system morphogenesis [GO:0021551]; embryonic pattern specification [GO:0009880]; ERBB2-ERBB4 signaling pathway [GO:0038135]; ERBB4 signaling pathway [GO:0038130]; ERBB4-ERBB4 signaling pathway [GO:0038138]; establishment of planar polarity involved in nephron morphogenesis [GO:0072046]; heart development [GO:0007507]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell differentiation [GO:0060644]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neurogenesis [GO:0022008]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; olfactory bulb interneuron differentiation [GO:0021889]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}; Single-pass type I membrane protein {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}. Note=In response to NRG1 treatment, the activated receptor is internalized.; SUBCELLULAR LOCATION: [ERBB4 intracellular domain]: Nucleus {ECO:0000269|PubMed:17486069}. Mitochondrion {ECO:0000269|PubMed:17486069}. Note=Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 colocalizes with YAP1 in the nucleus.
Q15306	reviewed	IRF4_HUMAN	Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5)	IRF4 MUM1	Homo sapiens (Human)	451	FUNCTION: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). {ECO:0000250|UniProtKB:Q64287}.		chromatin remodeling [GO:0006338]; defense response to protozoan [GO:0042832]; immune system process [GO:0002376]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of T-helper cell differentiation [GO:0045622]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell activation [GO:0042110]; T-helper 17 cell lineage commitment [GO:0072540]	chromatin [GO:0000785]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator activity [GO:0003713]; chromatin remodeling [GO:0006338]; defense response to protozoan [GO:0042832]; immune system process [GO:0002376]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of T-helper cell differentiation [GO:0045622]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell activation [GO:0042110]; T-helper 17 cell lineage commitment [GO:0072540]	SUBCELLULAR LOCATION: Nucleus.
Q15311	reviewed	RBP1_HUMAN	RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1)	RALBP1 RLIP RLIP1 RLIP76	Homo sapiens (Human)	655	FUNCTION: Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}.	MISCELLANEOUS: Originally designated as dinitrophenyl S-glutathione (DNP-SG) ATPase due to its ability to stimulate ATP hydrolysis in the presence of DNP-SG. {ECO:0000303|PubMed:10924126}.	chemotaxis [GO:0006935]; doxorubicin transport [GO:1900753]; endocytosis [GO:0006897]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein phosphorylation [GO:0001934]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]; chemotaxis [GO:0006935]; doxorubicin transport [GO:1900753]; endocytosis [GO:0006897]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein phosphorylation [GO:0001934]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11437348}; Peripheral membrane protein {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:15610018}. Cytoplasm, cytosol {ECO:0000269|PubMed:15610018, ECO:0000269|PubMed:22319010}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q62796}. Nucleus {ECO:0000269|PubMed:22319010}. Mitochondrion {ECO:0000269|PubMed:21822277}. Note=Cytosolic protein that transiently associates with the mitotic spindle poles in early prophase, and dissociates from them after completion of mitosis (By similarity). Targeted to the plasma membrane through its interaction with RALB, directed by FGF signaling. Docking on the membrane is required to transduce the Ral signal (By similarity). Recruited by RALA to the mitochondrion during mitosis where it regulates mitochondrial fission (PubMed:21822277). Nuclear localization is cell cycle dependent while membrane localization is seen in adherent cells (PubMed:22319010). The region involved in membrane association could form transmembrane domains and expose a part of the protein extracellularly (Probable). {ECO:0000250|UniProtKB:Q62796, ECO:0000250|UniProtKB:Q9PT60, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:22319010, ECO:0000305|PubMed:15610018}.
Q15319	reviewed	PO4F3_HUMAN	POU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3C) (Brain-3C) (Brn-3C)	POU4F3 BRN3C	Homo sapiens (Human)	338	FUNCTION: Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q63955, ECO:0000269|PubMed:18228599}.		axon extension [GO:0048675]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal ganglion cell axon guidance [GO:0031290]; sensory perception of sound [GO:0007605]; vestibulocochlear nerve development [GO:0021562]; visual perception [GO:0007601]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; axon extension [GO:0048675]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal ganglion cell axon guidance [GO:0031290]; sensory perception of sound [GO:0007605]; vestibulocochlear nerve development [GO:0021562]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18228599, ECO:0000269|PubMed:28790396}. Cytoplasm {ECO:0000269|PubMed:28790396}. Note=Preferentially localized in the nucleus. {ECO:0000269|PubMed:28790396}.
Q15323	reviewed	K1H1_HUMAN	Keratin, type I cuticular Ha1 (Hair keratin, type I Ha1) (Keratin-31) (K31)	KRT31 HHA1 HKA1 KRTHA1	Homo sapiens (Human)	416		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]	structural constituent of cytoskeleton [GO:0005200]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; structural constituent of cytoskeleton [GO:0005200]; epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
Q15326	reviewed	ZMY11_HUMAN	Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69)	ZMYND11 BRAM1 BS69	Homo sapiens (Human)	602	FUNCTION: Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250|UniProtKB:Q8R5C8, ECO:0000269|PubMed:10734313, ECO:0000269|PubMed:16565076, ECO:0000269|PubMed:24675531}.; FUNCTION: (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. {ECO:0000269|PubMed:26845565}.		cell cycle [GO:0007049]; chromatin organization [GO:0006325]; defense response to virus [GO:0051607]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of JNK cascade [GO:0046329]; regulation of signal transduction [GO:0009966]; regulation of transcription elongation by RNA polymerase II [GO:0034243]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	double-stranded DNA binding [GO:0003690]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; double-stranded DNA binding [GO:0003690]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; chromatin organization [GO:0006325]; defense response to virus [GO:0051607]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of JNK cascade [GO:0046329]; regulation of signal transduction [GO:0009966]; regulation of transcription elongation by RNA polymerase II [GO:0034243]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16565076, ECO:0000269|PubMed:19766626, ECO:0000269|PubMed:24675531, ECO:0000269|PubMed:25593309}. Chromosome {ECO:0000269|PubMed:16565076}. Note=Associates with chromatin and mitotic chromosomes. {ECO:0000269|PubMed:16565076}.
Q15327	reviewed	ANKR1_HUMAN	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible gene C-193 protein) (Cytokine-inducible nuclear protein)	ANKRD1 C193 CARP HA1A2	Homo sapiens (Human)	319	FUNCTION: May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. {ECO:0000269|PubMed:15805281, ECO:0000269|PubMed:7730328}.		cardiac muscle tissue morphogenesis [GO:0055008]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of DNA biosynthetic process [GO:2000279]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of protein secretion [GO:0050714]; protein kinase C signaling [GO:0070528]; regulation of transcription by RNA polymerase II [GO:0006357]; response to muscle stretch [GO:0035994]; sarcomere organization [GO:0045214]; skeletal muscle cell differentiation [GO:0035914]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; I band [GO:0031674]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; p53 binding [GO:0002039]; R-SMAD binding [GO:0070412]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; titin binding [GO:0031432]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; I band [GO:0031674]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; p53 binding [GO:0002039]; R-SMAD binding [GO:0070412]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; titin binding [GO:0031432]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; cardiac muscle tissue morphogenesis [GO:0055008]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of DNA biosynthetic process [GO:2000279]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of protein secretion [GO:0050714]; protein kinase C signaling [GO:0070528]; regulation of transcription by RNA polymerase II [GO:0006357]; response to muscle stretch [GO:0035994]; sarcomere organization [GO:0045214]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15805281, ECO:0000269|PubMed:7730328}.
Q15329	reviewed	E2F5_HUMAN	Transcription factor E2F5 (E2F-5)	E2F5	Homo sapiens (Human)	346	FUNCTION: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14}.		cell projection organization [GO:0030030]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell projection organization [GO:0030030]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q15334	reviewed	L2GL1_HUMAN	Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein)	LLGL1 DLG4 HUGL HUGL1	Homo sapiens (Human)	1064	FUNCTION: Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}.	MISCELLANEOUS: Down-regulation of LLGL1 is associated with the progression of colorectal cancer and melanoma. Located within the Smith-Magenis syndrome region on chromosome 17; deleted in patients with this syndrome.; MISCELLANEOUS: Expression increases cell adhesion and decreases cell migration. Substitutes for Drosophila l(2)gl tumor suppressor function in vivo.	axonogenesis [GO:0007409]; cortical actin cytoskeleton organization [GO:0030866]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; protein-containing complex assembly [GO:0065003]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of Notch signaling pathway [GO:0008593]; regulation of protein secretion [GO:0050708]	adherens junction [GO:0005912]; axon [GO:0030424]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; early endosome membrane [GO:0031901]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; protein kinase binding [GO:0019901]; structural molecule activity [GO:0005198]	adherens junction [GO:0005912]; axon [GO:0030424]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; early endosome membrane [GO:0031901]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; protein kinase binding [GO:0019901]; structural molecule activity [GO:0005198]; axonogenesis [GO:0007409]; cortical actin cytoskeleton organization [GO:0030866]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; protein-containing complex assembly [GO:0065003]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of Notch signaling pathway [GO:0008593]; regulation of protein secretion [GO:0050708]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12725730, ECO:0000269|PubMed:7542763}. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developing axons (By similarity). {ECO:0000250}.
Q15345	reviewed	LRC41_HUMAN	Leucine-rich repeat-containing protein 41 (Protein Muf1)	LRRC41 MUF1 PP7759	Homo sapiens (Human)	812	FUNCTION: Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}.		protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; protein ubiquitination [GO:0016567]	
Q15349	reviewed	KS6A2_HUMAN	Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)	RPS6KA2 MAPKAPK1C RSK3	Homo sapiens (Human)	733	FUNCTION: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.		brain renin-angiotensin system [GO:0002035]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to carbohydrate stimulus [GO:0071322]; chemical synaptic transmission [GO:0007268]; heart contraction [GO:0060047]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of meiotic nuclear division [GO:0045835]; oocyte maturation [GO:0001556]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; regulation of protein processing [GO:0070613]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ribosomal protein S6 kinase activity [GO:0004711]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ribosomal protein S6 kinase activity [GO:0004711]; brain renin-angiotensin system [GO:0002035]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to carbohydrate stimulus [GO:0071322]; chemical synaptic transmission [GO:0007268]; heart contraction [GO:0060047]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of meiotic nuclear division [GO:0045835]; oocyte maturation [GO:0001556]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; regulation of protein processing [GO:0070613]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7623830}. Cytoplasm {ECO:0000269|PubMed:7623830}.
Q15361	reviewed	TTF1_HUMAN	Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I)	TTF1	Homo sapiens (Human)	905	FUNCTION: Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}.		DNA-templated transcription termination [GO:0006353]; negative regulation of DNA replication [GO:0008156]; termination of RNA polymerase I transcription [GO:0006363]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-templated transcription termination [GO:0006353]; negative regulation of DNA replication [GO:0008156]; termination of RNA polymerase I transcription [GO:0006363]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q62187}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q62187}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q62187}. Note=May be localized to the nucleolus in an NPM1/B23-dependent manner. May be displaced from the nucleolus into the nucleoplasm in an CDKN2A/ARF-dependent manner. May shuttle back and forth from nucleoplasm to nucleolus. {ECO:0000250|UniProtKB:Q62187}.
Q15363	reviewed	TMED2_HUMAN	Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1)	TMED2 RNP24	Homo sapiens (Human)	201	FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing. {ECO:0000269|PubMed:10761932, ECO:0000269|PubMed:17693410, ECO:0000269|PubMed:20361938, ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331}.	MISCELLANEOUS: Ectopic expression of TMED2 alone does not result in its proper cis-Golgi network localization. Coexpression of TMED10 is necessary, and coexpression of TMED3 and/or TMED9 is facilitating localization. Down-regulation of TMED10 expression reduces TMED2 protein level.	allantois development [GO:1905069]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; chorion development [GO:0060717]; COPI coating of Golgi vesicle [GO:0048205]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; heart looping [GO:0001947]; inflammatory response [GO:0006954]; intracellular protein transport [GO:0006886]; labyrinthine layer blood vessel development [GO:0060716]; maintenance of protein localization in organelle [GO:0072595]; maternal placenta development [GO:0001893]; multicellular organism growth [GO:0035264]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of GTPase activity [GO:0034260]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; neural tube closure [GO:0001843]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of gene expression [GO:0010628]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of SREBP signaling pathway [GO:2000638]; somite rostral/caudal axis specification [GO:0032525]; vesicle cargo loading [GO:0035459]	COPI-coated vesicle [GO:0030137]; COPI-coated vesicle membrane [GO:0030663]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; transport vesicle [GO:0030133]; zymogen granule membrane [GO:0042589]	frizzled binding [GO:0005109]; smoothened binding [GO:0005119]	COPI-coated vesicle [GO:0030137]; COPI-coated vesicle membrane [GO:0030663]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; transport vesicle [GO:0030133]; zymogen granule membrane [GO:0042589]; frizzled binding [GO:0005109]; smoothened binding [GO:0005119]; allantois development [GO:1905069]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; chorion development [GO:0060717]; COPI coating of Golgi vesicle [GO:0048205]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; heart looping [GO:0001947]; inflammatory response [GO:0006954]; intracellular protein transport [GO:0006886]; labyrinthine layer blood vessel development [GO:0060716]; maintenance of protein localization in organelle [GO:0072595]; maternal placenta development [GO:0001893]; multicellular organism growth [GO:0035264]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of GTPase activity [GO:0034260]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; neural tube closure [GO:0001843]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of gene expression [GO:0010628]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of SREBP signaling pathway [GO:2000638]; somite rostral/caudal axis specification [GO:0032525]; vesicle cargo loading [GO:0035459]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:9472029}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Note=Cycles between compartments of the early secretatory pathway. {ECO:0000269|PubMed:12237308}.
Q15365	reviewed	PCBP1_HUMAN	Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3)	PCBP1	Homo sapiens (Human)	356	FUNCTION: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:7607214, PubMed:7556077, PubMed:8152927, PubMed:15731341). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; viral RNA genome replication [GO:0039694]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]	cadherin binding [GO:0045296]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific single stranded DNA binding [GO:0098847]; single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; cadherin binding [GO:0045296]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific single stranded DNA binding [GO:0098847]; single-stranded DNA binding [GO:0003697]; positive regulation of transcription by RNA polymerase II [GO:0045944]; viral RNA genome replication [GO:0039694]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7607214}. Cytoplasm {ECO:0000269|PubMed:7607214}. Note=Loosely bound in the nucleus (PubMed:7607214). May shuttle between the nucleus and the cytoplasm (PubMed:7607214). {ECO:0000269|PubMed:7607214}.
Q15366	reviewed	PCBP2_HUMAN	Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2)	PCBP2	Homo sapiens (Human)	365	FUNCTION: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:7607214, PubMed:12414943). Major cellular poly(rC)-binding protein (PubMed:12414943). Binds also poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; IRES-dependent viral translational initiation [GO:0075522]; mRNA metabolic process [GO:0016071]; negative regulation of defense response to virus [GO:0050687]; negative regulation of innate immune response [GO:0045824]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of gene expression [GO:0010468]; regulation of RNA metabolic process [GO:0051252]; viral RNA genome replication [GO:0039694]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]	C-rich single-stranded DNA binding [GO:1990829]; enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; C-rich single-stranded DNA binding [GO:1990829]; enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; IRES-dependent viral translational initiation [GO:0075522]; mRNA metabolic process [GO:0016071]; negative regulation of defense response to virus [GO:0050687]; negative regulation of innate immune response [GO:0045824]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of gene expression [GO:0010468]; regulation of RNA metabolic process [GO:0051252]; viral RNA genome replication [GO:0039694]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7607214}. Cytoplasm {ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:7607214}. Note=Loosely bound in the nucleus (PubMed:7607214). May shuttle between the nucleus and the cytoplasm (PubMed:7607214). {ECO:0000269|PubMed:7607214}.
Q15369	reviewed	ELOC_HUMAN	Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1)	ELOC TCEB1	Homo sapiens (Human)	112	FUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P83940, ECO:0000269|PubMed:7821821}.; FUNCTION: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694, PubMed:26138980, PubMed:29779948, PubMed:30166453, PubMed:29775578). This includes the von Hippel-Lindau ubiquitination complex CBC(VHL) (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694). As part of a multisubunit ubiquitin ligase complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:26138980, PubMed:29779948, PubMed:29775578). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). {ECO:0000250|UniProtKB:P83940, ECO:0000269|PubMed:10205047, ECO:0000269|PubMed:12004076, ECO:0000269|PubMed:12050673, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:19920177, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453}.		protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; target-directed miRNA degradation [GO:0140958]; transcription initiation at RNA polymerase II promoter [GO:0006367]; ubiquitin-dependent protein catabolic process [GO:0006511]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; elongin complex [GO:0070449]; nucleoplasm [GO:0005654]	protein-macromolecule adaptor activity [GO:0030674]; transcription corepressor binding [GO:0001222]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; elongin complex [GO:0070449]; nucleoplasm [GO:0005654]; protein-macromolecule adaptor activity [GO:0030674]; transcription corepressor binding [GO:0001222]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; target-directed miRNA degradation [GO:0140958]; transcription initiation at RNA polymerase II promoter [GO:0006367]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:34700328}.
Q15370	reviewed	ELOB_HUMAN	Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2)	ELOB TCEB2	Homo sapiens (Human)	118	FUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P62869, ECO:0000269|PubMed:7638163}.; FUNCTION: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694, PubMed:26138980, PubMed:29779948, PubMed:29775578). This includes the von Hippel-Lindau ubiquitination complex CBC(VHL) (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694). As part of a multisubunit ubiquitin ligase complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:26138980, PubMed:29779948, PubMed:29775578). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). {ECO:0000250|UniProtKB:P62869, ECO:0000269|PubMed:10205047, ECO:0000269|PubMed:12004076, ECO:0000269|PubMed:12050673, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948}.		positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; target-directed miRNA degradation [GO:0140958]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; elongin complex [GO:0070449]; nucleoplasm [GO:0005654]; VCB complex [GO:0030891]	transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; elongin complex [GO:0070449]; nucleoplasm [GO:0005654]; VCB complex [GO:0030891]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; target-directed miRNA degradation [GO:0140958]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:34700328}.
Q15375	reviewed	EPHA7_HUMAN	Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11)	EPHA7 EHK3 HEK11	Homo sapiens (Human)	998	FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. {ECO:0000269|PubMed:17726105}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Expressed in lung cancer cells, lacks the kinase domain and is most probably secreted. {ECO:0000305}.	axon guidance [GO:0007411]; brain development [GO:0007420]; branching morphogenesis of a nerve [GO:0048755]; ephrin receptor signaling pathway [GO:0048013]; modulation of chemical synaptic transmission [GO:0050804]; negative chemotaxis [GO:0050919]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of synapse assembly [GO:0051964]; nephric duct morphogenesis [GO:0072178]; neuron apoptotic process [GO:0051402]; phosphorylation [GO:0016310]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell-cell adhesion [GO:0022407]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of postsynapse organization [GO:0099175]; regulation of protein autophosphorylation [GO:0031952]; retinal ganglion cell axon guidance [GO:0031290]	dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; chemorepellent activity [GO:0045499]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; protein tyrosine kinase activity [GO:0004713]; transmembrane-ephrin receptor activity [GO:0005005]	dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; chemorepellent activity [GO:0045499]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; protein tyrosine kinase activity [GO:0004713]; transmembrane-ephrin receptor activity [GO:0005005]; axon guidance [GO:0007411]; brain development [GO:0007420]; branching morphogenesis of a nerve [GO:0048755]; ephrin receptor signaling pathway [GO:0048013]; modulation of chemical synaptic transmission [GO:0050804]; negative chemotaxis [GO:0050919]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of synapse assembly [GO:0051964]; nephric duct morphogenesis [GO:0072178]; neuron apoptotic process [GO:0051402]; phosphorylation [GO:0016310]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell-cell adhesion [GO:0022407]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of postsynapse organization [GO:0099175]; regulation of protein autophosphorylation [GO:0031952]; retinal ganglion cell axon guidance [GO:0031290]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q15382	reviewed	RHEB_HUMAN	GTP-binding protein Rheb (Ras homolog enriched in brain) (EC 3.6.5.-)	RHEB RHEB2	Homo sapiens (Human)	184	FUNCTION: Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12906785, PubMed:12271141, PubMed:12842888, PubMed:12869586, PubMed:15340059, PubMed:15854902, PubMed:16098514, PubMed:20381137, PubMed:24529379, PubMed:22819219, PubMed:29416044, PubMed:32470140, PubMed:33157014). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:33157014, PubMed:29236692). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (PubMed:24529379). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059). {ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0000269|PubMed:33157014}.	MISCELLANEOUS: The conserved catalytic Gln-64 found in other Ras-like GTPases seems not to be involved in GTP hydrolysis in RHEB. {ECO:0000269|PubMed:15340059}.	cellular response to nutrient levels [GO:0031669]; negative regulation of cold-induced thermogenesis [GO:0120163]; oligodendrocyte differentiation [GO:0048709]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of cell cycle [GO:0051726]; regulation of macroautophagy [GO:0016241]; regulation of type B pancreatic cell development [GO:2000074]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spliceosomal complex [GO:0005681]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spliceosomal complex [GO:0005681]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; cellular response to nutrient levels [GO:0031669]; negative regulation of cold-induced thermogenesis [GO:0120163]; oligodendrocyte differentiation [GO:0048709]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of cell cycle [GO:0051726]; regulation of macroautophagy [GO:0016241]; regulation of type B pancreatic cell development [GO:2000074]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000269|PubMed:22002721}; Cytoplasmic side {ECO:0000269|PubMed:15489334}. Lysosome membrane {ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:33157014}; Lipid-anchor {ECO:0000269|PubMed:22002721}; Cytoplasmic side {ECO:0000269|PubMed:15489334}. Golgi apparatus membrane {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000305|PubMed:22002721}; Cytoplasmic side {ECO:0000305|PubMed:22002721}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000269|PubMed:22002721}; Cytoplasmic side {ECO:0000269|PubMed:22002721}. Cytoplasm, cytosol {ECO:0000269|PubMed:22002721}. Note=Farnesylation is required for recruitment to lysosomal membranes, where it activates the mTORC1 complex. {ECO:0000269|PubMed:24529379}.
Q15386	reviewed	UBE3C_HUMAN	Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)	UBE3C KIAA0010 KIAA10	Homo sapiens (Human)	1083	FUNCTION: E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains (PubMed:11278995, PubMed:12692129, PubMed:16341092, PubMed:16601690, PubMed:24811749, PubMed:24158444, PubMed:25752573, PubMed:25752577, PubMed:34239127, PubMed:33637724, PubMed:32039437). Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:9575161, PubMed:32039437). Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome (PubMed:24158444, PubMed:28396413, PubMed:31375563). Also catalyzes 'Lys-29'- and 'Lys-48'-linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins (PubMed:24811749, PubMed:31375563). Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'-linked ubiquitination of PIK3C3/VPS34, promoting its degradation (PubMed:33637724). Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains; with some preference for 'Lys-48' linkages (PubMed:11278995, PubMed:16601690, PubMed:25752577). Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome (PubMed:21167755). Catalyzes ubiquitination and degradation of CAND2 (PubMed:12692129). {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:16341092, ECO:0000269|PubMed:16601690, ECO:0000269|PubMed:21167755, ECO:0000269|PubMed:24158444, ECO:0000269|PubMed:24811749, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:31375563, ECO:0000269|PubMed:32039437, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:9575161}.		protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	proteasome complex [GO:0000502]	ubiquitin protein ligase activity [GO:0061630]	proteasome complex [GO:0000502]; ubiquitin protein ligase activity [GO:0061630]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q15388	reviewed	TOM20_HUMAN	Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20)	TOMM20 KIAA0016	Homo sapiens (Human)	145	FUNCTION: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. {ECO:0000250, ECO:0000250|UniProtKB:Q62760}.		protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; response to 3,3',5-triiodo-L-thyronine [GO:1905242]; response to muscle activity [GO:0014850]; tRNA import into mitochondrion [GO:0016031]	cell periphery [GO:0071944]; migrasome [GO:0140494]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; sperm midpiece [GO:0097225]	mitochondrion targeting sequence binding [GO:0030943]; protein-transporting ATPase activity [GO:0015450]; unfolded protein binding [GO:0051082]	cell periphery [GO:0071944]; migrasome [GO:0140494]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; sperm midpiece [GO:0097225]; mitochondrion targeting sequence binding [GO:0030943]; protein-transporting ATPase activity [GO:0015450]; unfolded protein binding [GO:0051082]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; response to 3,3',5-triiodo-L-thyronine [GO:1905242]; response to muscle activity [GO:0014850]; tRNA import into mitochondrion [GO:0016031]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:25764979, ECO:0000269|PubMed:25997101, ECO:0000269|PubMed:31644573}; Single-pass membrane protein {ECO:0000255}.
Q15389	reviewed	ANGP1_HUMAN	Angiopoietin-1 (ANG-1)	ANGPT1 KIAA0003	Homo sapiens (Human)	498	FUNCTION: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:30689269, ECO:0000269|PubMed:9204896}.	MISCELLANEOUS: It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.	activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; angiogenesis [GO:0001525]; cell-substrate adhesion [GO:0031589]; glomerulus vasculature development [GO:0072012]; hemopoiesis [GO:0030097]; heparin biosynthetic process [GO:0030210]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular permeability [GO:0043116]; neuron apoptotic process [GO:0051402]; positive chemotaxis [GO:0050918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood-brain barrier permeability [GO:1905605]; positive regulation of cell adhesion [GO:0045785]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of receptor internalization [GO:0002092]; protein localization to cell surface [GO:0034394]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of macrophage migration inhibitory factor signaling pathway [GO:2000446]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; regulation of tumor necrosis factor production [GO:0032680]; sprouting angiogenesis [GO:0002040]; Tie signaling pathway [GO:0048014]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; receptor tyrosine kinase binding [GO:0030971]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; receptor tyrosine kinase binding [GO:0030971]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; angiogenesis [GO:0001525]; cell-substrate adhesion [GO:0031589]; glomerulus vasculature development [GO:0072012]; hemopoiesis [GO:0030097]; heparin biosynthetic process [GO:0030210]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular permeability [GO:0043116]; neuron apoptotic process [GO:0051402]; positive chemotaxis [GO:0050918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood-brain barrier permeability [GO:1905605]; positive regulation of cell adhesion [GO:0045785]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of receptor internalization [GO:0002092]; protein localization to cell surface [GO:0034394]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of macrophage migration inhibitory factor signaling pathway [GO:2000446]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; regulation of tumor necrosis factor production [GO:0032680]; sprouting angiogenesis [GO:0002040]; Tie signaling pathway [GO:0048014]	SUBCELLULAR LOCATION: Secreted.
Q15392	reviewed	DHC24_HUMAN	Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1)	DHCR24 KIAA0018	Homo sapiens (Human)	516	FUNCTION: Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:25637936, PubMed:22178193). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892). {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:21671375, ECO:0000269|PubMed:22010141, ECO:0000269|PubMed:22178193, ECO:0000269|PubMed:25637936}.		amyloid precursor protein catabolic process [GO:0042987]; apoptotic process [GO:0006915]; cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; male genitalia development [GO:0030539]; membrane organization [GO:0061024]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; plasminogen activation [GO:0031639]; protein localization [GO:0008104]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; response to hormone [GO:0009725]; response to oxidative stress [GO:0006979]; skin development [GO:0043588]; steroid metabolic process [GO:0008202]; tissue development [GO:0009888]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634]	delta24(24-1) sterol reductase activity [GO:0000246]; delta24-sterol reductase activity [GO:0050614]; enzyme binding [GO:0019899]; FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; peptide antigen binding [GO:0042605]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634]; delta24(24-1) sterol reductase activity [GO:0000246]; delta24-sterol reductase activity [GO:0050614]; enzyme binding [GO:0019899]; FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; peptide antigen binding [GO:0042605]; amyloid precursor protein catabolic process [GO:0042987]; apoptotic process [GO:0006915]; cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; male genitalia development [GO:0030539]; membrane organization [GO:0061024]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; plasminogen activation [GO:0031639]; protein localization [GO:0008104]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; response to hormone [GO:0009725]; response to oxidative stress [GO:0006979]; skin development [GO:0043588]; steroid metabolic process [GO:0008202]; tissue development [GO:0009888]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:22010141}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:11007892}; Single-pass membrane protein {ECO:0000255}.
Q15393	reviewed	SF3B3_HUMAN	Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130)	SF3B3 KIAA0017 SAP130	Homo sapiens (Human)	1217	FUNCTION: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077) (Probable). {ECO:0000269|PubMed:10490618, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28781166, ECO:0000305|PubMed:33509932}.		mRNA splicing, via spliceosome [GO:0000398]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	protein-containing complex binding [GO:0044877]; U2 snRNA binding [GO:0030620]	catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; protein-containing complex binding [GO:0044877]; U2 snRNA binding [GO:0030620]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10490618, ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300, ECO:0000269|PubMed:28781166}.
Q15397	reviewed	PUM3_HUMAN	Pumilio homolog 3 (HBV X-transactivated gene 5 protein) (HBV XAg-transactivated protein 5) (Minor histocompatibility antigen HA-8) (HLA-HA8)	PUM3 cPERP-C KIAA0020 PUF-A XTP5	Homo sapiens (Human)	648	FUNCTION: Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity). {ECO:0000250|UniProtKB:X1WGX5, ECO:0000269|PubMed:21266351, ECO:0000269|PubMed:25512524}.		regulation of protein ADP-ribosylation [GO:0010835]; regulation of translation [GO:0006417]	chromosome [GO:0005694]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	chromosome [GO:0005694]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; regulation of protein ADP-ribosylation [GO:0010835]; regulation of translation [GO:0006417]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:21266351, ECO:0000269|Ref.6}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21266351}. Chromosome {ECO:0000269|PubMed:20813266}. Note=Localizes predominantly in the nucleolus with minor punctate signals in the nucleoplasm. {ECO:0000269|PubMed:21266351}.
Q15398	reviewed	DLGP5_HUMAN	Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP)	DLGAP5 DLG7 KIAA0008	Homo sapiens (Human)	846	FUNCTION: Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}.		centrosome localization [GO:0051642]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic spindle organization [GO:0007052]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; regulation of mitotic cell cycle [GO:0007346]; signaling [GO:0023052]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616]	microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616]; microtubule binding [GO:0008017]; centrosome localization [GO:0051642]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic spindle organization [GO:0007052]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; regulation of mitotic cell cycle [GO:0007346]; signaling [GO:0023052]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
Q15399	reviewed	TLR1_HUMAN	Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)	TLR1 KIAA0012	Homo sapiens (Human)	786	FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:21078852}.		cellular response to triacyl bacterial lipopeptide [GO:0071727]; detection of triacyl bacterial lipopeptide [GO:0042495]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of tumor necrosis factor production [GO:0032760]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354]	identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354]; identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; detection of triacyl bacterial lipopeptide [GO:0042495]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of tumor necrosis factor production [GO:0032760]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16880211}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9EPQ1}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus {ECO:0000269|PubMed:16880211}. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. {ECO:0000269|PubMed:16880211}.
Q15406	reviewed	NR6A1_HUMAN	Nuclear receptor subfamily 6 group A member 1 (Germ cell nuclear factor) (GCNF) (hGCNF) (Retinoid receptor-related testis-specific receptor) (RTR) (hRTR)	NR6A1 GCNF	Homo sapiens (Human)	480	FUNCTION: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity). {ECO:0000250}.		gamete generation [GO:0007276]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; gamete generation [GO:0007276]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q15413	reviewed	RYR3_HUMAN	Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor)	RYR3 HBRR	Homo sapiens (Human)	4870	FUNCTION: Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction (PubMed:12354756, PubMed:9395096). May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling. {ECO:0000250|UniProtKB:Q92736, ECO:0000269|PubMed:12354756, ECO:0000269|PubMed:9395096}.		calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to ATP [GO:0071318]; cellular response to caffeine [GO:0071313]; cellular response to calcium ion [GO:0071277]; cellular response to magnesium ion [GO:0071286]; intracellular calcium ion homeostasis [GO:0006874]; protein homotetramerization [GO:0051289]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; striated muscle contraction [GO:0006941]	calcium channel complex [GO:0034704]; membrane [GO:0016020]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018]	calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calcium-release channel activity [GO:0015278]; calmodulin binding [GO:0005516]; ryanodine-sensitive calcium-release channel activity [GO:0005219]	calcium channel complex [GO:0034704]; membrane [GO:0016020]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calcium-release channel activity [GO:0015278]; calmodulin binding [GO:0005516]; ryanodine-sensitive calcium-release channel activity [GO:0005219]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to ATP [GO:0071318]; cellular response to caffeine [GO:0071313]; cellular response to calcium ion [GO:0071277]; cellular response to magnesium ion [GO:0071286]; intracellular calcium ion homeostasis [GO:0006874]; protein homotetramerization [GO:0051289]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; striated muscle contraction [GO:0006941]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9TS33}; Multi-pass membrane protein {ECO:0000255}.
Q15415	reviewed	RBY1F_HUMAN	RNA-binding motif protein, Y chromosome, family 1 member F/J (Y chromosome RNA recognition motif 2)	RBMY1F YRRM2; RBMY1J	Homo sapiens (Human)	496	FUNCTION: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. {ECO:0000269|PubMed:8269511}.	MISCELLANEOUS: The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.	mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus.
Q15417	reviewed	CNN3_HUMAN	Calponin-3 (Calponin, acidic isoform)	CNN3	Homo sapiens (Human)	329	FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.		actin filament organization [GO:0007015]; actomyosin structure organization [GO:0031032]; epithelial cell differentiation [GO:0030855]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]	actin filament binding [GO:0051015]; cadherin binding involved in cell-cell adhesion [GO:0098641]; calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; actin filament binding [GO:0051015]; cadherin binding involved in cell-cell adhesion [GO:0098641]; calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]; actin filament organization [GO:0007015]; actomyosin structure organization [GO:0031032]; epithelial cell differentiation [GO:0030855]	
Q15418	reviewed	KS6A1_HUMAN	Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)	RPS6KA1 MAPKAPK1A RSK1	Homo sapiens (Human)	735	FUNCTION: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:16223362, PubMed:15117958, PubMed:12213813, PubMed:9430688, PubMed:17360704, PubMed:26158630, PubMed:18722121, PubMed:35772404). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}.		cell cycle [GO:0007049]; chemical synaptic transmission [GO:0007268]; hepatocyte proliferation [GO:0072574]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of TOR signaling [GO:0032007]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of translation in response to stress [GO:0043555]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; synapse [GO:0045202]	ATP binding [GO:0005524]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ribosomal protein S6 kinase activity [GO:0004711]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; synapse [GO:0045202]; ATP binding [GO:0005524]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ribosomal protein S6 kinase activity [GO:0004711]; cell cycle [GO:0007049]; chemical synaptic transmission [GO:0007268]; hepatocyte proliferation [GO:0072574]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of TOR signaling [GO:0032007]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of translation in response to stress [GO:0043555]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
Q15424	reviewed	SAFB1_HUMAN	Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein)	SAFB HAP HET SAFB1	Homo sapiens (Human)	915	FUNCTION: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}.		chromatin organization [GO:0006325]; intracellular estrogen receptor signaling pathway [GO:0030520]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]	midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; chromatin organization [GO:0006325]; intracellular estrogen receptor signaling pathway [GO:0030520]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19674106, ECO:0000269|PubMed:22693546}.
Q15427	reviewed	SF3B4_HUMAN	Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49)	SF3B4 SAP49	Homo sapiens (Human)	424	FUNCTION: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well (PubMed:10882114). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643}.		mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; U2-type prespliceosome assembly [GO:1903241]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	RNA binding [GO:0003723]; splicing factor binding [GO:1990935]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300}.
Q15428	reviewed	SF3A2_HUMAN	Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62)	SF3A2 SAP62	Homo sapiens (Human)	464	FUNCTION: Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29361316, PubMed:29360106, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277}.		mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of neuron projection development [GO:0010976]; spliceosomal complex assembly [GO:0000245]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of neuron projection development [GO:0010976]; spliceosomal complex assembly [GO:0000245]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00130, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:21349847, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277}.
Q15431	reviewed	SYCP1_HUMAN	Synaptonemal complex protein 1 (SCP-1) (Cancer/testis antigen 8) (CT8)	SYCP1 SCP1	Homo sapiens (Human)	976	FUNCTION: Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. {ECO:0000250|UniProtKB:Q62209}.		cell division [GO:0051301]; chiasma assembly [GO:0051026]; homologous chromosome pairing at meiosis [GO:0007129]; lateral element assembly [GO:0051878]; meiotic DNA repair synthesis [GO:0000711]; protein homotetramerization [GO:0051289]; reciprocal meiotic recombination [GO:0007131]; regulation of protein localization [GO:0032880]; sperm DNA condensation [GO:0035092]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	autosome [GO:0030849]; central element [GO:0000801]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; male germ cell nucleus [GO:0001673]; synaptonemal complex [GO:0000795]; transverse filament [GO:0000802]	DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]	autosome [GO:0030849]; central element [GO:0000801]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; male germ cell nucleus [GO:0001673]; synaptonemal complex [GO:0000795]; transverse filament [GO:0000802]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; cell division [GO:0051301]; chiasma assembly [GO:0051026]; homologous chromosome pairing at meiosis [GO:0007129]; lateral element assembly [GO:0051878]; meiotic DNA repair synthesis [GO:0000711]; protein homotetramerization [GO:0051289]; reciprocal meiotic recombination [GO:0007131]; regulation of protein localization [GO:0032880]; sperm DNA condensation [GO:0035092]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q62209}. Chromosome {ECO:0000250|UniProtKB:Q62209}. Chromosome, centromere {ECO:0000250|UniProtKB:Q62209}. Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (By similarity). Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (By similarity). {ECO:0000250|UniProtKB:Q03410, ECO:0000250|UniProtKB:Q62209}.
Q15435	reviewed	PP1R7_HUMAN	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22)	PPP1R7 SDS22	Homo sapiens (Human)	360	FUNCTION: Regulatory subunit of protein phosphatase 1. {ECO:0000250}.		positive regulation of protein dephosphorylation [GO:0035307]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	enzyme regulator activity [GO:0030234]; protein phosphatase regulator activity [GO:0019888]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; enzyme regulator activity [GO:0030234]; protein phosphatase regulator activity [GO:0019888]; positive regulation of protein dephosphorylation [GO:0035307]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q15436	reviewed	SC23A_HUMAN	Protein transport protein Sec23A (hSec23A) (SEC23-related protein A)	SEC23A	Homo sapiens (Human)	765	FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q01405, ECO:0000269|PubMed:16980979, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:27551091, ECO:0000269|PubMed:8898360}.		COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886]; protein localization to plasma membrane [GO:0072659]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]	GTPase activator activity [GO:0005096]; zinc ion binding [GO:0008270]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; GTPase activator activity [GO:0005096]; zinc ion binding [GO:0008270]; COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000305|PubMed:8898360}; Peripheral membrane protein {ECO:0000269|PubMed:8898360}; Cytoplasmic side {ECO:0000269|PubMed:8898360}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:8898360}; Peripheral membrane protein {ECO:0000269|PubMed:8898360}; Cytoplasmic side {ECO:0000269|PubMed:8898360}. Cytoplasm, cytosol {ECO:0000269|PubMed:8898360}. Note=Enriched at endoplasmic reticulum exit sites, also known as transitional endoplasmic reticulum (tER). {ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:8898360}.
Q15437	reviewed	SC23B_HUMAN	Protein transport protein Sec23B (hSec23B) (SEC23-related protein B)	SEC23B	Homo sapiens (Human)	767	FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. {ECO:0000250|UniProtKB:Q15436}.		COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]	GTPase activator activity [GO:0005096]; zinc ion binding [GO:0008270]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; GTPase activator activity [GO:0005096]; zinc ion binding [GO:0008270]; COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q15436}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:26522472}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15436}.
Q15438	reviewed	CYH1_HUMAN	Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1)	CYTH1 D17S811E PSCD1	Homo sapiens (Human)	398	FUNCTION: Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. {ECO:0000250|UniProtKB:Q9QX11, ECO:0000269|PubMed:10652308, ECO:0000269|PubMed:29420262, ECO:0000269|PubMed:9653114}.		establishment of epithelial cell polarity [GO:0090162]; regulation of ARF protein signal transduction [GO:0032012]; regulation of cell adhesion [GO:0030155]; vesicle-mediated transport [GO:0016192]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289]; establishment of epithelial cell polarity [GO:0090162]; regulation of ARF protein signal transduction [GO:0032012]; regulation of cell adhesion [GO:0030155]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17398095}; Peripheral membrane protein {ECO:0000269|PubMed:17398095}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9QX11}. Note=Colocalized with TJP1 during epithelial polarization. {ECO:0000250|UniProtKB:Q9QX11}.
Q15459	reviewed	SF3A1_HUMAN	Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114)	SF3A1 SAP114	Homo sapiens (Human)	793	FUNCTION: Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277}.		mRNA 3'-splice site recognition [GO:0000389]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]; RNA binding [GO:0003723]; mRNA 3'-splice site recognition [GO:0000389]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277}. Nucleus speckle {ECO:0000269|PubMed:21349847}.
Q15464	reviewed	SHB_HUMAN	SH2 domain-containing adapter protein B	SHB	Homo sapiens (Human)	509	FUNCTION: Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}.		angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; B cell proliferation [GO:0042100]; hematopoietic stem cell proliferation [GO:0071425]; negative regulation of oocyte maturation [GO:1900194]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of T-helper cell differentiation [GO:0045624]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	phosphotyrosine residue binding [GO:0001784]; signaling receptor complex adaptor activity [GO:0030159]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; phosphotyrosine residue binding [GO:0001784]; signaling receptor complex adaptor activity [GO:0030159]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; B cell proliferation [GO:0042100]; hematopoietic stem cell proliferation [GO:0071425]; negative regulation of oocyte maturation [GO:1900194]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of T-helper cell differentiation [GO:0045624]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
Q15465	reviewed	SHH_HUMAN	Sonic hedgehog protein (SHH) (EC 3.1.-.-) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]	SHH	Homo sapiens (Human)	462	FUNCTION: [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q62226}.; FUNCTION: [Sonic hedgehog protein N-product]: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites (PubMed:24863049). Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (PubMed:10753901). In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (PubMed:10753901). {ECO:0000250|UniProtKB:Q62226, ECO:0000269|PubMed:10753901, ECO:0000269|PubMed:24863049, ECO:0000303|PubMed:24522195}.		alpha-beta T cell differentiation [GO:0046632]; androgen metabolic process [GO:0008209]; animal organ formation [GO:0048645]; apoptotic signaling pathway [GO:0097190]; artery development [GO:0060840]; axon guidance [GO:0007411]; Bergmann glial cell differentiation [GO:0060020]; blood coagulation [GO:0007596]; branching involved in blood vessel morphogenesis [GO:0001569]; branching involved in salivary gland morphogenesis [GO:0060445]; branching involved in ureteric bud morphogenesis [GO:0001658]; branching morphogenesis of an epithelial tube [GO:0048754]; bud outgrowth involved in lung branching [GO:0060447]; camera-type eye development [GO:0043010]; canonical Wnt signaling pathway [GO:0060070]; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369]; cell development [GO:0048468]; cell fate specification [GO:0001708]; cell-cell signaling [GO:0007267]; cellular response to lithium ion [GO:0071285]; central nervous system development [GO:0007417]; cerebellar granule cell precursor proliferation [GO:0021930]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral neural tube patterning [GO:0021904]; dorsal/ventral pattern formation [GO:0009953]; ectoderm development [GO:0007398]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic foregut morphogenesis [GO:0048617]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic skeletal system development [GO:0048706]; endocytosis [GO:0006897]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; epithelial-mesenchymal signaling involved in prostate gland development [GO:0060738]; establishment of epithelial cell polarity [GO:0090162]; forebrain development [GO:0030900]; formation of anatomical boundary [GO:0048859]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; hindbrain development [GO:0030902]; hindgut morphogenesis [GO:0007442]; inner ear development [GO:0048839]; intein-mediated protein splicing [GO:0016539]; intermediate filament organization [GO:0045109]; left lung development [GO:0060459]; limb bud formation [GO:0060174]; lung development [GO:0030324]; lung epithelium development [GO:0060428]; lung lobe morphogenesis [GO:0060463]; lung-associated mesenchyme development [GO:0060484]; lymphoid progenitor cell differentiation [GO:0002320]; male genitalia development [GO:0030539]; mesenchymal cell apoptotic process [GO:0097152]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesenchymal smoothened signaling pathway involved in prostate gland development [GO:0060783]; metanephric collecting duct development [GO:0072205]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; metanephros development [GO:0001656]; midbrain development [GO:0030901]; myoblast differentiation [GO:0045445]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of gene expression [GO:0010629]; negative regulation of kidney smooth muscle cell differentiation [GO:2000357]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of T cell differentiation in thymus [GO:0033085]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of ureter smooth muscle cell differentiation [GO:2000062]; negative thymic T cell selection [GO:0045060]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; neuron fate commitment [GO:0048663]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; osteoblast development [GO:0002076]; pancreas development [GO:0031016]; pattern specification process [GO:0007389]; polarity specification of anterior/posterior axis [GO:0009949]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of gene expression [GO:0010628]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of kidney smooth muscle cell differentiation [GO:2000358]; positive regulation of mesenchymal cell proliferation involved in ureter development [GO:2000729]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sclerotome development [GO:0061189]; positive regulation of skeletal muscle cell proliferation [GO:0014858]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureter smooth muscle cell differentiation [GO:2000063]; positive regulation of Wnt signaling pathway [GO:0030177]; positive thymic T cell selection [GO:0045059]; primary prostatic bud elongation [GO:0060516]; prostate epithelial cord elongation [GO:0060523]; prostate gland development [GO:0030850]; protein autoprocessing [GO:0016540]; protein import into nucleus [GO:0006606]; regulation of cell population proliferation [GO:0042127]; regulation of gene expression [GO:0010468]; regulation of glial cell proliferation [GO:0060251]; regulation of mesenchymal cell proliferation involved in prostate gland development [GO:0060782]; regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900175]; regulation of odontogenesis [GO:0042481]; regulation of prostatic bud formation [GO:0060685]; regulation of protein localization to nucleus [GO:1900180]; regulation of proteolysis [GO:0030162]; regulation of stem cell proliferation [GO:0072091]; right lung development [GO:0060458]; roof of mouth development [GO:0060021]; salivary gland cavitation [GO:0060662]; self proteolysis [GO:0097264]; skeletal muscle cell proliferation [GO:0014856]; skeletal muscle fiber differentiation [GO:0098528]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [GO:0021938]; somite development [GO:0061053]; spinal cord dorsal/ventral patterning [GO:0021513]; spinal cord motor neuron differentiation [GO:0021522]; stem cell development [GO:0048864]; stem cell proliferation [GO:0072089]; striated muscle tissue development [GO:0014706]; T cell differentiation in thymus [GO:0033077]; T cell proliferation [GO:0042098]; telencephalon regionalization [GO:0021978]; thalamus development [GO:0021794]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea morphogenesis [GO:0060439]; tracheoesophageal septum formation [GO:1905327]; trunk neural crest cell migration [GO:0036484]; vasculogenesis [GO:0001570]; ventral midline development [GO:0007418]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; endopeptidase activity [GO:0004175]; glycosaminoglycan binding [GO:0005539]; laminin-1 binding [GO:0043237]; morphogen activity [GO:0016015]; patched binding [GO:0005113]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; endopeptidase activity [GO:0004175]; glycosaminoglycan binding [GO:0005539]; laminin-1 binding [GO:0043237]; morphogen activity [GO:0016015]; patched binding [GO:0005113]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270]; alpha-beta T cell differentiation [GO:0046632]; androgen metabolic process [GO:0008209]; animal organ formation [GO:0048645]; apoptotic signaling pathway [GO:0097190]; artery development [GO:0060840]; axon guidance [GO:0007411]; Bergmann glial cell differentiation [GO:0060020]; blood coagulation [GO:0007596]; branching involved in blood vessel morphogenesis [GO:0001569]; branching involved in salivary gland morphogenesis [GO:0060445]; branching involved in ureteric bud morphogenesis [GO:0001658]; branching morphogenesis of an epithelial tube [GO:0048754]; bud outgrowth involved in lung branching [GO:0060447]; camera-type eye development [GO:0043010]; canonical Wnt signaling pathway [GO:0060070]; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369]; cell development [GO:0048468]; cell fate specification [GO:0001708]; cell-cell signaling [GO:0007267]; cellular response to lithium ion [GO:0071285]; central nervous system development [GO:0007417]; cerebellar granule cell precursor proliferation [GO:0021930]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral neural tube patterning [GO:0021904]; dorsal/ventral pattern formation [GO:0009953]; ectoderm development [GO:0007398]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic foregut morphogenesis [GO:0048617]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic skeletal system development [GO:0048706]; endocytosis [GO:0006897]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; epithelial-mesenchymal signaling involved in prostate gland development [GO:0060738]; establishment of epithelial cell polarity [GO:0090162]; forebrain development [GO:0030900]; formation of anatomical boundary [GO:0048859]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; hindbrain development [GO:0030902]; hindgut morphogenesis [GO:0007442]; inner ear development [GO:0048839]; intein-mediated protein splicing [GO:0016539]; intermediate filament organization [GO:0045109]; left lung development [GO:0060459]; limb bud formation [GO:0060174]; lung development [GO:0030324]; lung epithelium development [GO:0060428]; lung lobe morphogenesis [GO:0060463]; lung-associated mesenchyme development [GO:0060484]; lymphoid progenitor cell differentiation [GO:0002320]; male genitalia development [GO:0030539]; mesenchymal cell apoptotic process [GO:0097152]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesenchymal smoothened signaling pathway involved in prostate gland development [GO:0060783]; metanephric collecting duct development [GO:0072205]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; metanephros development [GO:0001656]; midbrain development [GO:0030901]; myoblast differentiation [GO:0045445]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of gene expression [GO:0010629]; negative regulation of kidney smooth muscle cell differentiation [GO:2000357]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of T cell differentiation in thymus [GO:0033085]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of ureter smooth muscle cell differentiation [GO:2000062]; negative thymic T cell selection [GO:0045060]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; neuron fate commitment [GO:0048663]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; osteoblast development [GO:0002076]; pancreas development [GO:0031016]; pattern specification process [GO:0007389]; polarity specification of anterior/posterior axis [GO:0009949]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of gene expression [GO:0010628]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of kidney smooth muscle cell differentiation [GO:2000358]; positive regulation of mesenchymal cell proliferation involved in ureter development [GO:2000729]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sclerotome development [GO:0061189]; positive regulation of skeletal muscle cell proliferation [GO:0014858]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureter smooth muscle cell differentiation [GO:2000063]; positive regulation of Wnt signaling pathway [GO:0030177]; positive thymic T cell selection [GO:0045059]; primary prostatic bud elongation [GO:0060516]; prostate epithelial cord elongation [GO:0060523]; prostate gland development [GO:0030850]; protein autoprocessing [GO:0016540]; protein import into nucleus [GO:0006606]; regulation of cell population proliferation [GO:0042127]; regulation of gene expression [GO:0010468]; regulation of glial cell proliferation [GO:0060251]; regulation of mesenchymal cell proliferation involved in prostate gland development [GO:0060782]; regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900175]; regulation of odontogenesis [GO:0042481]; regulation of prostatic bud formation [GO:0060685]; regulation of protein localization to nucleus [GO:1900180]; regulation of proteolysis [GO:0030162]; regulation of stem cell proliferation [GO:0072091]; right lung development [GO:0060458]; roof of mouth development [GO:0060021]; salivary gland cavitation [GO:0060662]; self proteolysis [GO:0097264]; skeletal muscle cell proliferation [GO:0014856]; skeletal muscle fiber differentiation [GO:0098528]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [GO:0021938]; somite development [GO:0061053]; spinal cord dorsal/ventral patterning [GO:0021513]; spinal cord motor neuron differentiation [GO:0021522]; stem cell development [GO:0048864]; stem cell proliferation [GO:0072089]; striated muscle tissue development [GO:0014706]; T cell differentiation in thymus [GO:0033077]; T cell proliferation [GO:0042098]; telencephalon regionalization [GO:0021978]; thalamus development [GO:0021794]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea morphogenesis [GO:0060439]; tracheoesophageal septum formation [GO:1905327]; trunk neural crest cell migration [GO:0036484]; vasculogenesis [GO:0001570]; ventral midline development [GO:0007418]	SUBCELLULAR LOCATION: [Sonic hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000305|PubMed:18534984}. Golgi apparatus membrane {ECO:0000305|PubMed:18534984}. Secreted {ECO:0000269|PubMed:24342078}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000305|PubMed:18534984}.; SUBCELLULAR LOCATION: [Sonic hedgehog protein N-product]: Cell membrane {ECO:0000250|UniProtKB:Q62226}; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (PubMed:24522195). Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides (PubMed:26875496, PubMed:24522195). {ECO:0000305|PubMed:24522195, ECO:0000305|PubMed:26875496}.
Q15466	reviewed	NR0B2_HUMAN	Nuclear receptor subfamily 0 group B member 2 (Orphan nuclear receptor SHP) (Small heterodimer partner)	NR0B2 SHP	Homo sapiens (Human)	257	FUNCTION: Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity). {ECO:0000250|UniProtKB:Q62227, ECO:0000269|PubMed:14752053}.		animal organ regeneration [GO:0031100]; bile acid and bile salt transport [GO:0015721]; cholesterol metabolic process [GO:0008203]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion [GO:0032024]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to organic cyclic compound [GO:0014070]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; peroxisome proliferator activated receptor binding [GO:0042975]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; peroxisome proliferator activated receptor binding [GO:0042975]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; animal organ regeneration [GO:0031100]; bile acid and bile salt transport [GO:0015721]; cholesterol metabolic process [GO:0008203]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion [GO:0032024]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to organic cyclic compound [GO:0014070]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:28797635}. Cytoplasm {ECO:0000269|PubMed:14752053}. Note=Colocalizes with NEUROD1 in the nucleus.
Q15468	reviewed	STIL_HUMAN	SCL-interrupting locus protein (TAL-1-interrupting locus protein)	STIL SIL	Homo sapiens (Human)	1287	FUNCTION: Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:9372240}.		centrosome duplication [GO:0051298]; determination of left/right symmetry [GO:0007368]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; forebrain development [GO:0030900]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; notochord development [GO:0030903]; positive regulation of centriole replication [GO:0046601]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of spindle assembly [GO:1905832]; protein localization to centrosome [GO:0071539]; regulation of centriole replication [GO:0046599]; regulation of mitotic spindle organization [GO:0060236]; smoothened signaling pathway [GO:0007224]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; procentriole replication complex [GO:0120099]	identical protein binding [GO:0042802]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; procentriole replication complex [GO:0120099]; identical protein binding [GO:0042802]; centrosome duplication [GO:0051298]; determination of left/right symmetry [GO:0007368]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; forebrain development [GO:0030900]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; notochord development [GO:0030903]; positive regulation of centriole replication [GO:0046601]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of spindle assembly [GO:1905832]; protein localization to centrosome [GO:0071539]; regulation of centriole replication [GO:0046599]; regulation of mitotic spindle organization [GO:0060236]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q60988}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835}.
Q15475	reviewed	SIX1_HUMAN	Homeobox protein SIX1 (Sine oculis homeobox homolog 1)	SIX1	Homo sapiens (Human)	284	FUNCTION: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (By similarity). Plays an important role in the development of several organs, including kidney, muscle and inner ear (By similarity). Depending on context, functions as transcriptional repressor or activator (By similarity). Lacks an activation domain, and requires interaction with EYA family members for transcription activation (PubMed:15141091). Mediates nuclear translocation of EYA1 and EYA2 (PubMed:19497856). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (PubMed:27923061, PubMed:23435380, PubMed:15141091, PubMed:19497856). Regulates the expression of numerous genes, including MYC, CCND1 and EZR (By similarity). Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2 (By similarity). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (By similarity). During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1 (PubMed:15123840). Promotes brown adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q62231, ECO:0000269|PubMed:15123840, ECO:0000269|PubMed:15141091, ECO:0000269|PubMed:19497856, ECO:0000269|PubMed:23435380, ECO:0000269|PubMed:27923061}.		aorta morphogenesis [GO:0035909]; apoptotic process [GO:0006915]; branching involved in ureteric bud morphogenesis [GO:0001658]; cellular response to 3,3',5-triiodo-L-thyronine [GO:1905243]; cochlea morphogenesis [GO:0090103]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic skeletal system morphogenesis [GO:0048704]; endothelin receptor signaling pathway [GO:0086100]; epithelial cell differentiation [GO:0030855]; facial nerve morphogenesis [GO:0021610]; fungiform papilla morphogenesis [GO:0061197]; gene expression [GO:0010467]; generation of neurons [GO:0048699]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; mesenchymal cell proliferation involved in ureter development [GO:0072198]; mesonephric tubule formation [GO:0072172]; metanephric mesenchyme development [GO:0072075]; middle ear morphogenesis [GO:0042474]; myoblast migration [GO:0051451]; myoblast proliferation [GO:0051450]; myotome development [GO:0061055]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell differentiation [GO:0014033]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; olfactory placode formation [GO:0030910]; organ induction [GO:0001759]; otic vesicle development [GO:0071599]; outflow tract morphogenesis [GO:0003151]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mesenchymal cell proliferation involved in ureter development [GO:2000729]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation [GO:0050678]; regulation of neuron differentiation [GO:0045664]; regulation of protein localization [GO:0032880]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of skeletal muscle cell proliferation [GO:0014857]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trigeminal ganglion development [GO:0061551]; ureter smooth muscle cell differentiation [GO:0072193]; ureteric bud development [GO:0001657]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; aorta morphogenesis [GO:0035909]; apoptotic process [GO:0006915]; branching involved in ureteric bud morphogenesis [GO:0001658]; cellular response to 3,3',5-triiodo-L-thyronine [GO:1905243]; cochlea morphogenesis [GO:0090103]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic skeletal system morphogenesis [GO:0048704]; endothelin receptor signaling pathway [GO:0086100]; epithelial cell differentiation [GO:0030855]; facial nerve morphogenesis [GO:0021610]; fungiform papilla morphogenesis [GO:0061197]; gene expression [GO:0010467]; generation of neurons [GO:0048699]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; mesenchymal cell proliferation involved in ureter development [GO:0072198]; mesonephric tubule formation [GO:0072172]; metanephric mesenchyme development [GO:0072075]; middle ear morphogenesis [GO:0042474]; myoblast migration [GO:0051451]; myoblast proliferation [GO:0051450]; myotome development [GO:0061055]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell differentiation [GO:0014033]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; olfactory placode formation [GO:0030910]; organ induction [GO:0001759]; otic vesicle development [GO:0071599]; outflow tract morphogenesis [GO:0003151]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mesenchymal cell proliferation involved in ureter development [GO:2000729]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation [GO:0050678]; regulation of neuron differentiation [GO:0045664]; regulation of protein localization [GO:0032880]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of skeletal muscle cell proliferation [GO:0014857]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trigeminal ganglion development [GO:0061551]; ureter smooth muscle cell differentiation [GO:0072193]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10801845, ECO:0000269|PubMed:17130831, ECO:0000269|PubMed:19497856}. Cytoplasm.
Q15477	reviewed	SKI2_HUMAN	Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP)	SKIC2 DDX13 SKI2W SKIV2 SKIV2L W	Homo sapiens (Human)	1246	FUNCTION: Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656). {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:32006463, ECO:0000269|PubMed:35120588}.		nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled ribosome [GO:0072344]	cytosol [GO:0005829]; nucleus [GO:0005634]; Ski complex [GO:0055087]	3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytosol [GO:0005829]; nucleus [GO:0005634]; Ski complex [GO:0055087]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled ribosome [GO:0072344]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16024656}. Cytoplasm {ECO:0000269|PubMed:16024656}.
Q15485	reviewed	FCN2_HUMAN	Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35)	FCN2 FCNL	Homo sapiens (Human)	313	FUNCTION: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. {ECO:0000269|PubMed:10679061, ECO:0000269|PubMed:17215869}.		cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; opsonization [GO:0008228]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]; recognition of apoptotic cell [GO:0043654]	blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370]	antigen binding [GO:0003823]; calcium-dependent protein binding [GO:0048306]; carbohydrate derivative binding [GO:0097367]; mannan binding [GO:2001065]; metal ion binding [GO:0046872]; proteoglycan binding [GO:0043394]; signaling receptor binding [GO:0005102]	blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370]; antigen binding [GO:0003823]; calcium-dependent protein binding [GO:0048306]; carbohydrate derivative binding [GO:0097367]; mannan binding [GO:2001065]; metal ion binding [GO:0046872]; proteoglycan binding [GO:0043394]; signaling receptor binding [GO:0005102]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; opsonization [GO:0008228]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]; recognition of apoptotic cell [GO:0043654]	SUBCELLULAR LOCATION: Secreted.
Q15493	reviewed	RGN_HUMAN	Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17) (Senescence marker protein 30) (SMP-30)	RGN SMP30	Homo sapiens (Human)	299	FUNCTION: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). {ECO:0000250}.		intracellular calcium ion homeostasis [GO:0006874]; kidney development [GO:0001822]; L-ascorbic acid biosynthetic process [GO:0019853]; liver regeneration [GO:0097421]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone development [GO:1903011]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA catabolic process [GO:1903625]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of flagellated sperm motility [GO:1901318]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of RNA biosynthetic process [GO:1902679]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of calcium-mediated signaling [GO:0050848]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]; gluconolactonase activity [GO:0004341]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]; gluconolactonase activity [GO:0004341]; zinc ion binding [GO:0008270]; intracellular calcium ion homeostasis [GO:0006874]; kidney development [GO:0001822]; L-ascorbic acid biosynthetic process [GO:0019853]; liver regeneration [GO:0097421]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone development [GO:1903011]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA catabolic process [GO:1903625]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of flagellated sperm motility [GO:1901318]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of RNA biosynthetic process [GO:1902679]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of calcium-mediated signaling [GO:0050848]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q15506	reviewed	SP17_HUMAN	Sperm surface protein Sp17 (Cancer/testis antigen 22) (CT22) (Sp17-1) (Sperm autoantigenic protein 17) (Sperm protein 17)	SPA17 SP17	Homo sapiens (Human)	151	FUNCTION: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity). {ECO:0000250}.		binding of sperm to zona pellucida [GO:0007339]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]	cilium [GO:0005929]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; sperm fibrous sheath [GO:0035686]; sperm principal piece [GO:0097228]	calmodulin binding [GO:0005516]	cilium [GO:0005929]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; sperm fibrous sheath [GO:0035686]; sperm principal piece [GO:0097228]; calmodulin binding [GO:0005516]; binding of sperm to zona pellucida [GO:0007339]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Q15517	reviewed	CDSN_HUMAN	Corneodesmosin (S protein)	CDSN	Homo sapiens (Human)	529	FUNCTION: Important for the epidermal barrier integrity. {ECO:0000269|PubMed:20691404}.		amyloid fibril formation [GO:1990000]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; corneocyte desquamation [GO:0003336]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; negative regulation of cornification [GO:1905716]; skin morphogenesis [GO:0043589]	cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; desmosome [GO:0030057]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	protein homodimerization activity [GO:0042803]	cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; desmosome [GO:0030057]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]; amyloid fibril formation [GO:1990000]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; corneocyte desquamation [GO:0003336]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; negative regulation of cornification [GO:1905716]; skin morphogenesis [GO:0043589]	SUBCELLULAR LOCATION: Secreted. Note=Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
Q15526	reviewed	SURF1_HUMAN	Surfeit locus protein 1	SURF1 SURF-1	Homo sapiens (Human)	300	FUNCTION: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. {ECO:0000269|PubMed:24027061, ECO:0000269|PubMed:9843204, ECO:0000305|PubMed:26321642}.		aerobic respiration [GO:0009060]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; respiratory chain complex IV assembly [GO:0008535]	mitochondrial respirasome [GO:0005746]; mitochondrion [GO:0005739]	cytochrome-c oxidase activity [GO:0004129]	mitochondrial respirasome [GO:0005746]; mitochondrion [GO:0005739]; cytochrome-c oxidase activity [GO:0004129]; aerobic respiration [GO:0009060]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; respiratory chain complex IV assembly [GO:0008535]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P09925}; Multi-pass membrane protein {ECO:0000255}.
Q15528	reviewed	MED22_HUMAN	Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5)	MED22 SURF5	Homo sapiens (Human)	200	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.		positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	core mediator complex [GO:0070847]; cytoplasm [GO:0005737]; mediator complex [GO:0016592]; nucleus [GO:0005634]	transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; cytoplasm [GO:0005737]; mediator complex [GO:0016592]; nucleus [GO:0005634]; transcription coregulator activity [GO:0003712]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q15532	reviewed	SSXT_HUMAN	Protein SSXT (Protein SYT) (Synovial sarcoma translocated to X chromosome protein)	SS18 SSXT SYT	Homo sapiens (Human)	418	FUNCTION: Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). {ECO:0000269|PubMed:15919756, ECO:0000269|PubMed:29374058}.		cell morphogenesis [GO:0000902]; chromatin remodeling [GO:0006338]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of cell differentiation [GO:0045596]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; microtubule cytoskeleton [GO:0015630]; npBAF complex [GO:0071564]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]	nuclear receptor coactivator activity [GO:0030374]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; microtubule cytoskeleton [GO:0015630]; npBAF complex [GO:0071564]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]; nuclear receptor coactivator activity [GO:0030374]; cell morphogenesis [GO:0000902]; chromatin remodeling [GO:0006338]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of cell differentiation [GO:0045596]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q15542	reviewed	TAF5_HUMAN	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100)	TAF5 TAF2D	Homo sapiens (Human)	800	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:8758937, PubMed:8942982, PubMed:9045704). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF5 is involved in two modules of TFIID, in TFIID-A together with TAF3 and TBP, and in TFIID-B with TAF8 (PubMed:33795473). Involved in contacts between TFIID and TFIIF in the PIC (PubMed:33795473). {ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:8758937, ECO:0000269|PubMed:8942982, ECO:0000269|PubMed:9045704}.		DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]	identical protein binding [GO:0042802]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; identical protein binding [GO:0042802]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus.
Q15543	reviewed	TAF13_HUMAN	Transcription initiation factor TFIID subunit 13 (Transcription initiation factor TFIID 18 kDa subunit) (TAF(II)18) (TAFII-18) (TAFII18)	TAF13 TAF2K TAFII18	Homo sapiens (Human)	124	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473, PubMed:9695952). TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes (PubMed:33795473). {ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:9695952}.		DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]; DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9695952}.
Q15544	reviewed	TAF11_HUMAN	Transcription initiation factor TFIID subunit 11 (TFIID subunit p30-beta) (Transcription initiation factor TFIID 28 kDa subunit) (TAF(II)28) (TAFII-28) (TAFII28)	TAF11 TAF2I PRO2134	Homo sapiens (Human)	211	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF11, together with TAF13 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes (PubMed:33795473). {ECO:0000269|PubMed:33795473}.		mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]	DNA binding [GO:0003677]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]	Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; DNA binding [GO:0003677]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus.
Q15545	reviewed	TAF7_HUMAN	Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55)	TAF7 TAF2F TAFII55	Homo sapiens (Human)	349	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:10438527). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269|PubMed:10438527, ECO:0000269|PubMed:33795473}.	MISCELLANEOUS: Overexpression of TAF7 in HeLa cells inhibits cyclin D1 and cyclin A gene transcription and causes the cells to accumulate in early S phase. In contrast, depletion of TAF7 from TFIID complexes by siRNAs increases histone H3 acetylation at both cyclin promoters and stimulates cyclins CCND1 and CCNA gene transcription.	DNA-templated transcription initiation [GO:0006352]; intracellular estrogen receptor signaling pathway [GO:0030520]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of MHC class I biosynthetic process [GO:0045344]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermine transport [GO:0000296]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase binding [GO:0035035]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; P-TEFb complex binding [GO:0106140]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TFIIH-class transcription factor complex binding [GO:0001097]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase binding [GO:0035035]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; P-TEFb complex binding [GO:0106140]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TFIIH-class transcription factor complex binding [GO:0001097]; transcription cis-regulatory region binding [GO:0000976]; DNA-templated transcription initiation [GO:0006352]; intracellular estrogen receptor signaling pathway [GO:0030520]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of MHC class I biosynthetic process [GO:0045344]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermine transport [GO:0000296]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9R1C0}.
Q15546	reviewed	PAQRB_HUMAN	Monocyte to macrophage differentiation factor (Progestin and adipoQ receptor family member 11) (Progestin and adipoQ receptor family member XI)	MMD PAQR11	Homo sapiens (Human)	238	FUNCTION: Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion. {ECO:0000250}.		positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein kinase activity [GO:0045860]; regulation of protein localization [GO:0032880]	Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	pore-forming activity [GO:0140911]; protein kinase activity [GO:0004672]; signaling receptor activity [GO:0038023]	Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; pore-forming activity [GO:0140911]; protein kinase activity [GO:0004672]; signaling receptor activity [GO:0038023]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein kinase activity [GO:0045860]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q15554	reviewed	TERF2_HUMAN	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein)	TERF2 TRBF2 TRF2	Homo sapiens (Human)	542	FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:20655466, ECO:0000269|PubMed:9476899}.		anterograde axonal transport [GO:0008089]; axonal transport of messenger ribonucleoprotein complex [GO:0099088]; cell cycle [GO:0007049]; cellular senescence [GO:0090398]; in utero embryonic development [GO:0001701]; negative regulation of beta-galactosidase activity [GO:1903770]; negative regulation of cellular senescence [GO:2000773]; negative regulation of exonuclease activity [GO:1905778]; negative regulation of gene expression [GO:0010629]; negative regulation of t-circle formation [GO:1904430]; negative regulation of telomere capping [GO:1904354]; negative regulation of telomere maintenance [GO:0032205]; negative regulation of telomere maintenance via recombination [GO:0032208]; negative regulation of telomere maintenance via semi-conservative replication [GO:0032214]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomere single strand break repair [GO:1903824]; negative regulation of telomeric D-loop disassembly [GO:1905839]; positive regulation of gene expression [GO:0010628]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of telomere maintenance [GO:0032206]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of telomere maintenance [GO:0032204]; regulation of telomere maintenance via telomerase [GO:0032210]; RNA-templated DNA biosynthetic process [GO:0006278]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomeric D-loop disassembly [GO:0061820]; telomeric loop formation [GO:0031627]	axon cytoplasm [GO:1904115]; chromosome, telomeric region [GO:0000781]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; shelterin complex [GO:0070187]	double-stranded telomeric DNA binding [GO:0003691]; enzyme binding [GO:0019899]; G-rich strand telomeric DNA binding [GO:0098505]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric DNA binding [GO:0042162]	axon cytoplasm [GO:1904115]; chromosome, telomeric region [GO:0000781]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; shelterin complex [GO:0070187]; double-stranded telomeric DNA binding [GO:0003691]; enzyme binding [GO:0019899]; G-rich strand telomeric DNA binding [GO:0098505]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric DNA binding [GO:0042162]; anterograde axonal transport [GO:0008089]; axonal transport of messenger ribonucleoprotein complex [GO:0099088]; cell cycle [GO:0007049]; cellular senescence [GO:0090398]; in utero embryonic development [GO:0001701]; negative regulation of beta-galactosidase activity [GO:1903770]; negative regulation of cellular senescence [GO:2000773]; negative regulation of exonuclease activity [GO:1905778]; negative regulation of gene expression [GO:0010629]; negative regulation of t-circle formation [GO:1904430]; negative regulation of telomere capping [GO:1904354]; negative regulation of telomere maintenance [GO:0032205]; negative regulation of telomere maintenance via recombination [GO:0032208]; negative regulation of telomere maintenance via semi-conservative replication [GO:0032214]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomere single strand break repair [GO:1903824]; negative regulation of telomeric D-loop disassembly [GO:1905839]; positive regulation of gene expression [GO:0010628]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of telomere maintenance [GO:0032206]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of telomere maintenance [GO:0032204]; regulation of telomere maintenance via telomerase [GO:0032210]; RNA-templated DNA biosynthetic process [GO:0006278]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomeric D-loop disassembly [GO:0061820]; telomeric loop formation [GO:0031627]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:20655466}. Chromosome, telomere {ECO:0000269|PubMed:20655466}. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
Q15555	reviewed	MARE2_HUMAN	Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2)	MAPRE2 RP1	Homo sapiens (Human)	327	FUNCTION: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). {ECO:0000250}.		cell division [GO:0051301]; positive regulation of ARF protein signal transduction [GO:0032014]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of GTPase activity [GO:0043547]; positive regulation of keratinocyte migration [GO:0051549]; protein localization to microtubule [GO:0035372]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; focal adhesion [GO:0005925]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; spindle midzone [GO:0051233]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; focal adhesion [GO:0005925]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; spindle midzone [GO:0051233]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901]; cell division [GO:0051301]; positive regulation of ARF protein signal transduction [GO:0032014]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of GTPase activity [GO:0043547]; positive regulation of keratinocyte migration [GO:0051549]; protein localization to microtubule [GO:0035372]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10188731}. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules.
Q15560	reviewed	TCEA2_HUMAN	Transcription elongation factor A protein 2 (Testis-specific S-II) (Transcription elongation factor S-II protein 2) (Transcription elongation factor TFIIS.l)	TCEA2	Homo sapiens (Human)	299	FUNCTION: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. {ECO:0000269|PubMed:12034815}.		DNA-templated transcription [GO:0006351]; DNA-templated transcription elongation [GO:0006354]; regulation of DNA-templated transcription elongation [GO:0032784]; transcription elongation by RNA polymerase II [GO:0006368]	centrosome [GO:0005813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; DNA-templated transcription [GO:0006351]; DNA-templated transcription elongation [GO:0006354]; regulation of DNA-templated transcription elongation [GO:0032784]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus.
Q15561	reviewed	TEAD4_HUMAN	Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1)	TEAD4 RTEF1 TCF13L1 TEF3	Homo sapiens (Human)	434	FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.		cell fate specification [GO:0001708]; DNA-templated transcription [GO:0006351]; embryo implantation [GO:0007566]; embryonic organ development [GO:0048568]; hippo signaling [GO:0035329]; muscle organ development [GO:0007517]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; trophectodermal cell fate commitment [GO:0001830]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell fate specification [GO:0001708]; DNA-templated transcription [GO:0006351]; embryo implantation [GO:0007566]; embryonic organ development [GO:0048568]; hippo signaling [GO:0035329]; muscle organ development [GO:0007517]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; trophectodermal cell fate commitment [GO:0001830]	SUBCELLULAR LOCATION: Nucleus.
Q15562	reviewed	TEAD2_HUMAN	Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2)	TEAD2 TEF4	Homo sapiens (Human)	447	FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.		cellular response to retinoic acid [GO:0071300]; embryonic heart tube morphogenesis [GO:0003143]; embryonic organ development [GO:0048568]; hippo signaling [GO:0035329]; lateral mesoderm development [GO:0048368]; neural tube closure [GO:0001843]; notochord development [GO:0030903]; paraxial mesoderm development [GO:0048339]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570]	chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TEAD-YAP complex [GO:0140552]; transcription regulator complex [GO:0005667]	disordered domain specific binding [GO:0097718]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]	chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TEAD-YAP complex [GO:0140552]; transcription regulator complex [GO:0005667]; disordered domain specific binding [GO:0097718]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]; cellular response to retinoic acid [GO:0071300]; embryonic heart tube morphogenesis [GO:0003143]; embryonic organ development [GO:0048568]; hippo signaling [GO:0035329]; lateral mesoderm development [GO:0048368]; neural tube closure [GO:0001843]; notochord development [GO:0030903]; paraxial mesoderm development [GO:0048339]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Nucleus.
Q15569	reviewed	TESK1_HUMAN	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1)	TESK1	Homo sapiens (Human)	626	FUNCTION: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}.		actin cytoskeleton organization [GO:0030036]; establishment of vesicle localization [GO:0051650]; negative regulation of cilium assembly [GO:1902018]; negative regulation of phosphorylation [GO:0042326]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; phosphorylation [GO:0016310]; podocyte cell migration [GO:0090521]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of protein localization [GO:0032880]; spermatogenesis [GO:0007283]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; actin cytoskeleton organization [GO:0030036]; establishment of vesicle localization [GO:0051650]; negative regulation of cilium assembly [GO:1902018]; negative regulation of phosphorylation [GO:0042326]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; phosphorylation [GO:0016310]; podocyte cell migration [GO:0090521]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of protein localization [GO:0032880]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15584898}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q63572}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25849865}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q63572}. Note=Colocalizes with SPRY4 in vesicular spots in the cytoplasm (PubMed:15584898). Localized to F-actin-rich lamellipodia at the cell periphery following fibronectin-mediated cell adhesion of Schwann cells (By similarity). {ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898}.
Q15572	reviewed	TAF1C_HUMAN	TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 110 kDa) (TAFI110) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C)	TAF1C	Homo sapiens (Human)	869	FUNCTION: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:15970593}.		transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase I promoter [GO:0006361]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668]	RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase I promoter [GO:0006361]	SUBCELLULAR LOCATION: Nucleus.
Q15573	reviewed	TAF1A_HUMAN	TATA box-binding protein-associated factor RNA polymerase I subunit A (RNA polymerase I-specific TBP-associated factor 48 kDa) (TAFI48) (TATA box-binding protein-associated factor 1A) (TBP-associated factor 1A) (Transcription factor SL1) (Transcription initiation factor SL1/TIF-IB subunit A)	TAF1A	Homo sapiens (Human)	450	FUNCTION: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:7801123}.		transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]	microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668]	DNA binding [GO:0003677]	microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668]; DNA binding [GO:0003677]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
Q15582	reviewed	BGH3_HUMAN	Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (Kerato-epithelin) (RGD-containing collagen-associated protein) (RGD-CAP)	TGFBI BIGH3	Homo sapiens (Human)	683	FUNCTION: Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity). {ECO:0000250|UniProtKB:O11780, ECO:0000269|PubMed:8024701}.		angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; extracellular matrix organization [GO:0030198]; localization [GO:0051179]; negative regulation of cell adhesion [GO:0007162]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	cell adhesion molecule binding [GO:0050839]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; cell adhesion molecule binding [GO:0050839]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; extracellular matrix organization [GO:0030198]; localization [GO:0051179]; negative regulation of cell adhesion [GO:0007162]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18450759, ECO:0000269|PubMed:26273833, ECO:0000269|PubMed:8024701}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:8077289}. Note=May be associated both with microfibrils and with the cell surface (PubMed:8077289). {ECO:0000269|PubMed:8077289}.
Q15583	reviewed	TGIF1_HUMAN	Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1)	TGIF1 TGIF	Homo sapiens (Human)	401	FUNCTION: Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.		cellular response to growth factor stimulus [GO:0071363]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; response to xenobiotic stimulus [GO:0009410]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	co-SMAD binding [GO:0070410]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; co-SMAD binding [GO:0070410]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to growth factor stimulus [GO:0071363]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus.
Q15596	reviewed	NCOA2_HUMAN	Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)	NCOA2 BHLHE75 SRC2 TIF2	Homo sapiens (Human)	1464	FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:8670870, PubMed:23508108, PubMed:9430642). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:8670870, PubMed:23508108, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:8670870, PubMed:23508108, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression (PubMed:8670870, PubMed:23508108, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}.		cellular response to hormone stimulus [GO:0032870]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; circadian regulation of gene expression [GO:0032922]; locomotor rhythm [GO:0045475]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid metabolic process [GO:0019216]; response to progesterone [GO:0032570]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	aryl hydrocarbon receptor binding [GO:0017162]; chromatin binding [GO:0003682]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]; aryl hydrocarbon receptor binding [GO:0017162]; chromatin binding [GO:0003682]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; transcription coactivator activity [GO:0003713]; cellular response to hormone stimulus [GO:0032870]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; circadian regulation of gene expression [GO:0032922]; locomotor rhythm [GO:0045475]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid metabolic process [GO:0019216]; response to progesterone [GO:0032570]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8670870}.
Q15599	reviewed	NHRF2_HUMAN	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)	NHERF2 SLC9A3R2	Homo sapiens (Human)	337	FUNCTION: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:9096337}.		protein localization to plasma membrane [GO:0072659]; protein-containing complex assembly [GO:0065003]	apical plasma membrane [GO:0016324]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphatase binding [GO:0019902]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; type 2 metabotropic glutamate receptor binding [GO:0031799]; type 3 metabotropic glutamate receptor binding [GO:0031800]	apical plasma membrane [GO:0016324]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphatase binding [GO:0019902]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; type 2 metabotropic glutamate receptor binding [GO:0031799]; type 3 metabotropic glutamate receptor binding [GO:0031800]; protein localization to plasma membrane [GO:0072659]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:9054412}; Peripheral membrane protein {ECO:0000269|PubMed:9054412}. Nucleus {ECO:0000269|PubMed:9054412}. Apical cell membrane {ECO:0000250}. Note=Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern. {ECO:0000250}.
Q155Q3	reviewed	DIXC1_HUMAN	Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1)	DIXDC1 CCD1 KIAA1735	Homo sapiens (Human)	683	FUNCTION: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000269|PubMed:15262978, ECO:0000269|PubMed:21189423}.	MISCELLANEOUS: [Isoform 1]: Major isoform. Ubiquitously expressed.; MISCELLANEOUS: [Isoform 2]: Major isoform. Preferentially expressed in cardiac and skeletal muscles. {ECO:0000305}.	canonical Wnt signaling pathway [GO:0060070]; cerebral cortex radially oriented cell migration [GO:0021799]; forebrain ventricular zone progenitor cell division [GO:0021869]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of microtubule cytoskeleton organization [GO:0070507]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]	actin binding [GO:0003779]; gamma-tubulin binding [GO:0043015]; protein domain specific binding [GO:0019904]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; actin binding [GO:0003779]; gamma-tubulin binding [GO:0043015]; protein domain specific binding [GO:0019904]; canonical Wnt signaling pathway [GO:0060070]; cerebral cortex radially oriented cell migration [GO:0021799]; forebrain ventricular zone progenitor cell division [GO:0021869]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of microtubule cytoskeleton organization [GO:0070507]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:16814745}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:16814745}. Cytoplasm {ECO:0000269|PubMed:20085589}. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis (PubMed:19375513). Associated with actin stress fiber at the filament ends (PubMed:16814745). {ECO:0000269|PubMed:16814745, ECO:0000269|PubMed:19375513}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16814745}. Note=Not associated with stress fibers. {ECO:0000269|PubMed:16814745}.
Q15628	reviewed	TRADD_HUMAN	Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)	TRADD	Homo sapiens (Human)	312	FUNCTION: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (PubMed:7758105, PubMed:8612133, PubMed:23955153). Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (PubMed:7758105, PubMed:8612133). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). {ECO:0000250|UniProtKB:Q3U0V2, ECO:0000269|PubMed:23955153, ECO:0000269|PubMed:7758105, ECO:0000269|PubMed:8612133}.		apoptotic process [GO:0006915]; cellular response to tumor necrosis factor [GO:0071356]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of hair follicle development [GO:0051798]; positive regulation of inflammatory response [GO:0050729]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; tumor necrosis factor receptor superfamily complex [GO:0002947]	death domain binding [GO:0070513]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; tumor necrosis factor receptor binding [GO:0005164]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; tumor necrosis factor receptor superfamily complex [GO:0002947]; death domain binding [GO:0070513]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; tumor necrosis factor receptor binding [GO:0005164]; apoptotic process [GO:0006915]; cellular response to tumor necrosis factor [GO:0071356]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of hair follicle development [GO:0051798]; positive regulation of inflammatory response [GO:0050729]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3U0V2}. Cytoplasm {ECO:0000269|PubMed:11684708}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11684708}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250|UniProtKB:Q3U0V2}.
Q15629	reviewed	TRAM1_HUMAN	Translocating chain-associated membrane protein 1 (Protein TRAM1)	TRAM1 TRAM	Homo sapiens (Human)	374	FUNCTION: Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel (PubMed:1315422, PubMed:8616892, PubMed:9506517, PubMed:12475939, PubMed:32013668). Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER (PubMed:9506517). May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport (PubMed:32013668). Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane (PubMed:8616892). Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane (PubMed:12475939). Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (PubMed:20430023). {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:1315422, ECO:0000269|PubMed:20430023, ECO:0000269|PubMed:32013668, ECO:0000269|PubMed:8616892, ECO:0000269|PubMed:9506517, ECO:0000303|PubMed:32013668}.; FUNCTION: (Microbial infection) In case of cytomegalovirus infection, participates in US2- and US11-mediated ER-to-cytosol retrotranslocation and subsequent degradation of major histocompatibility complex (MHC) class I heavy chains, thereby decreasing the immune detection by cytotoxic T-cells. {ECO:0000269|PubMed:19121997}.		cotranslational protein targeting to membrane [GO:0006613]; protein insertion into ER membrane [GO:0045048]; response to unfolded protein [GO:0006986]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	signaling receptor activity [GO:0038023]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; signaling receptor activity [GO:0038023]; cotranslational protein targeting to membrane [GO:0006613]; protein insertion into ER membrane [GO:0045048]; response to unfolded protein [GO:0006986]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:1315422, ECO:0000269|PubMed:20430023, ECO:0000269|PubMed:8616892, ECO:0000269|PubMed:9506517}; Multi-pass membrane protein {ECO:0000255}.
Q15631	reviewed	TSN_HUMAN	Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO)	TSN	Homo sapiens (Human)	228	FUNCTION: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.; FUNCTION: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.		DNA recombination [GO:0006310]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; siRNA processing [GO:0030422]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoribonuclease complex [GO:1902555]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoribonuclease complex [GO:1902555]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697]; DNA recombination [GO:0006310]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; siRNA processing [GO:0030422]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11801738}. Nucleus {ECO:0000269|PubMed:11801738}.
Q15633	reviewed	TRBP2_HUMAN	RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein)	TARBP2 TRBP	Homo sapiens (Human)	366	FUNCTION: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity) (PubMed:15973356, PubMed:16142218, PubMed:16271387, PubMed:16357216, PubMed:16424907, PubMed:17452327, PubMed:18178619). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (PubMed:23063653). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (PubMed:30927622). {ECO:0000250|UniProtKB:P97473, ECO:0000255|HAMAP-Rule:MF_03034, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:23063653, ECO:0000269|PubMed:30927622}.; FUNCTION: (Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs (PubMed:2011739, PubMed:11438532, PubMed:12475984). This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha (PubMed:11438532). May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR (PubMed:12475984). Mediates recruitment of FTSJ3 methyltransferase to HIV-1 RNA, leading to 2'-O-methylation of the viral genome, allowing HIV-1 to escape the innate immune system (PubMed:30626973). {ECO:0000269|PubMed:11438532, ECO:0000269|PubMed:12475984, ECO:0000269|PubMed:2011739, ECO:0000269|PubMed:30626973}.		global gene silencing by mRNA cleavage [GO:0098795]; miRNA processing [GO:0035196]; negative regulation of defense response to virus by host [GO:0050689]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; regulation of miRNA processing [GO:1903798]; regulation of regulatory ncRNA processing [GO:0070920]; regulation of siRNA processing [GO:0070921]; regulation of translation [GO:0006417]; regulation of viral transcription [GO:0046782]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]	double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; pre-miRNA binding [GO:0070883]; pre-mRNA binding [GO:0036002]; protein homodimerization activity [GO:0042803]; protein sequestering activity [GO:0140311]; siRNA binding [GO:0035197]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; pre-miRNA binding [GO:0070883]; pre-mRNA binding [GO:0036002]; protein homodimerization activity [GO:0042803]; protein sequestering activity [GO:0140311]; siRNA binding [GO:0035197]; global gene silencing by mRNA cleavage [GO:0098795]; miRNA processing [GO:0035196]; negative regulation of defense response to virus by host [GO:0050689]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; regulation of miRNA processing [GO:1903798]; regulation of regulatory ncRNA processing [GO:0070920]; regulation of siRNA processing [GO:0070921]; regulation of translation [GO:0006417]; regulation of viral transcription [GO:0046782]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
Q15637	reviewed	SF01_HUMAN	Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162)	SF1 ZFM1 ZNF162	Homo sapiens (Human)	639	FUNCTION: Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}.		Leydig cell differentiation [GO:0033327]; male sex determination [GO:0030238]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of smooth muscle cell proliferation [GO:0048662]; nuclear body organization [GO:0030575]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of steroid biosynthetic process [GO:0050810]; spliceosomal complex assembly [GO:0000245]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701]	identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]; Leydig cell differentiation [GO:0033327]; male sex determination [GO:0030238]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of smooth muscle cell proliferation [GO:0048662]; nuclear body organization [GO:0030575]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of steroid biosynthetic process [GO:0050810]; spliceosomal complex assembly [GO:0000245]	SUBCELLULAR LOCATION: Nucleus.
Q15642	reviewed	CIP4_HUMAN	Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10)	TRIP10 CIP4 STOT STP	Homo sapiens (Human)	601	FUNCTION: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}.		actin cytoskeleton organization [GO:0030036]; cell communication [GO:0007154]; endocytosis [GO:0006897]; signal transduction [GO:0007165]	cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]	identical protein binding [GO:0042802]; lipid binding [GO:0008289]	cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; actin cytoskeleton organization [GO:0030036]; cell communication [GO:0007154]; endocytosis [GO:0006897]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm, perinuclear region.
Q15643	reviewed	TRIPB_HUMAN	Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230)	TRIP11 CEV14	Homo sapiens (Human)	1979	FUNCTION: Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}.		cartilage development [GO:0051216]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; inner ear receptor cell stereocilium organization [GO:0060122]; transcription by RNA polymerase II [GO:0006366]; ventricular septum development [GO:0003281]; vesicle tethering to Golgi [GO:0099041]	cis-Golgi network [GO:0005801]; cytoskeleton [GO:0005856]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; inner acrosomal membrane [GO:0002079]; outer acrosomal membrane [GO:0002081]; transport vesicle [GO:0030133]	small GTPase binding [GO:0031267]; transcription coactivator activity [GO:0003713]	cis-Golgi network [GO:0005801]; cytoskeleton [GO:0005856]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; inner acrosomal membrane [GO:0002079]; outer acrosomal membrane [GO:0002081]; transport vesicle [GO:0030133]; small GTPase binding [GO:0031267]; transcription coactivator activity [GO:0003713]; cartilage development [GO:0051216]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; inner ear receptor cell stereocilium organization [GO:0060122]; transcription by RNA polymerase II [GO:0006366]; ventricular septum development [GO:0003281]; vesicle tethering to Golgi [GO:0099041]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115}; Peripheral membrane protein {ECO:0000269|PubMed:10189370}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10189370}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:25473115}. Note=Associates with the ends of centrosome-nucleated microtubules.
Q15645	reviewed	PCH2_HUMAN	Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13)	TRIP13 PCH2	Homo sapiens (Human)	432	FUNCTION: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959). {ECO:0000250|UniProtKB:Q3UA06, ECO:0000269|PubMed:28553959}.		double-strand break repair [GO:0006302]; female meiosis I [GO:0007144]; male meiosis I [GO:0007141]; meiotic recombination checkpoint signaling [GO:0051598]; mitotic spindle assembly checkpoint signaling [GO:0007094]; oocyte maturation [GO:0001556]; oogenesis [GO:0048477]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; transcription by RNA polymerase II [GO:0006366]	chromosome [GO:0005694]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; transcription coregulator activity [GO:0003712]	chromosome [GO:0005694]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; transcription coregulator activity [GO:0003712]; double-strand break repair [GO:0006302]; female meiosis I [GO:0007144]; male meiosis I [GO:0007141]; meiotic recombination checkpoint signaling [GO:0051598]; mitotic spindle assembly checkpoint signaling [GO:0007094]; oocyte maturation [GO:0001556]; oogenesis [GO:0048477]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; transcription by RNA polymerase II [GO:0006366]	
Q15646	reviewed	OASL_HUMAN	2'-5'-oligoadenylate synthase-like protein (2'-5'-OAS-related protein) (2'-5'-OAS-RP) (59 kDa 2'-5'-oligoadenylate synthase-like protein) (Thyroid receptor-interacting protein 14) (TR-interacting protein 14) (TRIP-14) (p59 OASL) (p59OASL)	OASL TRIP14	Homo sapiens (Human)	514	FUNCTION: Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:20074559, ECO:0000269|PubMed:9826176}.	MISCELLANEOUS: [Isoform 3]: Has antiviral activity against RNA viruses. {ECO:0000305}.	defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of viral genome replication [GO:0045071]; positive regulation of RIG-I signaling pathway [GO:1900246]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; nuclear thyroid hormone receptor binding [GO:0046966]; nucleotidyltransferase activity [GO:0016779]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; nuclear thyroid hormone receptor binding [GO:0046966]; nucleotidyltransferase activity [GO:0016779]; RNA binding [GO:0003723]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of viral genome replication [GO:0045071]; positive regulation of RIG-I signaling pathway [GO:1900246]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: [Isoform p56]: Nucleus, nucleolus. Cytoplasm.; SUBCELLULAR LOCATION: [Isoform p30]: Cytoplasm.
Q15648	reviewed	MED1_HUMAN	Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)	MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2	Homo sapiens (Human)	1581	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.		androgen biosynthetic process [GO:0006702]; angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; brain development [GO:0007420]; cell morphogenesis [GO:0000902]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to thyroid hormone stimulus [GO:0097067]; embryonic heart tube development [GO:0035050]; embryonic hemopoiesis [GO:0035162]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic placenta development [GO:0001892]; enucleate erythrocyte development [GO:0048822]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; erythrocyte development [GO:0048821]; fat cell differentiation [GO:0045444]; G0 to G1 transition [GO:0045023]; hematopoietic stem cell differentiation [GO:0060218]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; keratinocyte differentiation [GO:0030216]; lactation [GO:0007595]; lens development in camera-type eye [GO:0002088]; liver development [GO:0001889]; mammary gland branching involved in pregnancy [GO:0060745]; mammary gland branching involved in thelarche [GO:0060744]; megakaryocyte development [GO:0035855]; monocyte differentiation [GO:0030224]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; protein import into nucleus [GO:0006606]; protein ubiquitination [GO:0016567]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vitamin D receptor signaling pathway [GO:0070562]; retinal pigment epithelium development [GO:0003406]; RNA polymerase II preinitiation complex assembly [GO:0051123]; thyroid hormone generation [GO:0006590]; thyroid hormone mediated signaling pathway [GO:0002154]; ventricular trabecula myocardium morphogenesis [GO:0003222]	chromatin [GO:0000785]; core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor binding [GO:0140297]; general transcription initiation factor binding [GO:0140296]; histone acetyltransferase binding [GO:0035035]; LBD domain binding [GO:0050693]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; peroxisome proliferator activated receptor binding [GO:0042975]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]	chromatin [GO:0000785]; core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor binding [GO:0140297]; general transcription initiation factor binding [GO:0140296]; histone acetyltransferase binding [GO:0035035]; LBD domain binding [GO:0050693]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; peroxisome proliferator activated receptor binding [GO:0042975]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; androgen biosynthetic process [GO:0006702]; angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; brain development [GO:0007420]; cell morphogenesis [GO:0000902]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to thyroid hormone stimulus [GO:0097067]; embryonic heart tube development [GO:0035050]; embryonic hemopoiesis [GO:0035162]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic placenta development [GO:0001892]; enucleate erythrocyte development [GO:0048822]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; erythrocyte development [GO:0048821]; fat cell differentiation [GO:0045444]; G0 to G1 transition [GO:0045023]; hematopoietic stem cell differentiation [GO:0060218]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; keratinocyte differentiation [GO:0030216]; lactation [GO:0007595]; lens development in camera-type eye [GO:0002088]; liver development [GO:0001889]; mammary gland branching involved in pregnancy [GO:0060745]; mammary gland branching involved in thelarche [GO:0060744]; megakaryocyte development [GO:0035855]; monocyte differentiation [GO:0030224]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; protein import into nucleus [GO:0006606]; protein ubiquitination [GO:0016567]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vitamin D receptor signaling pathway [GO:0070562]; retinal pigment epithelium development [GO:0003406]; RNA polymerase II preinitiation complex assembly [GO:0051123]; thyroid hormone generation [GO:0006590]; thyroid hormone mediated signaling pathway [GO:0002154]; ventricular trabecula myocardium morphogenesis [GO:0003222]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:16314496, ECO:0000269|PubMed:16574658}. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.
Q15649	reviewed	ZNHI3_HUMAN	Zinc finger HIT domain-containing protein 3 (HNF-4a coactivator) (Thyroid hormone receptor interactor 3) (Thyroid receptor-interacting protein 3) (TR-interacting protein 3) (TRIP-3)	ZNHIT3 TRIP3	Homo sapiens (Human)	155			box C/D snoRNP assembly [GO:0000492]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of DNA-templated transcription [GO:0006355]; snoRNA localization [GO:0048254]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]	metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]; metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966]; box C/D snoRNP assembly [GO:0000492]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of DNA-templated transcription [GO:0006355]; snoRNA localization [GO:0048254]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28335020}. Nucleus {ECO:0000269|PubMed:28335020}.
Q15650	reviewed	TRIP4_HUMAN	Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4)	TRIP4 RQT4	Homo sapiens (Human)	581	FUNCTION: Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription (PubMed:10454579, PubMed:25219498). May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions (PubMed:10454579, PubMed:25219498). Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1 (PubMed:12077347). Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). {ECO:0000250|UniProtKB:Q9QXN3, ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26924529, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}.		intracellular estrogen receptor signaling pathway [GO:0030520]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of myoblast differentiation [GO:0045661]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	activating signal cointegrator 1 complex [GO:0099053]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; neuromuscular junction [GO:0031594]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	histone acetyltransferase binding [GO:0035035]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin-like protein ligase binding [GO:0044389]; zinc ion binding [GO:0008270]	activating signal cointegrator 1 complex [GO:0099053]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; neuromuscular junction [GO:0031594]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; histone acetyltransferase binding [GO:0035035]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin-like protein ligase binding [GO:0044389]; zinc ion binding [GO:0008270]; intracellular estrogen receptor signaling pathway [GO:0030520]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of myoblast differentiation [GO:0045661]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:26924529}. Cytoplasm, cytosol {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20873783}. Note=Cytoplasmic under conditions of serum deprivation (PubMed:10454579). Colocalizes with NEK6 in the centrosome (PubMed:20873783). {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}.
Q15652	reviewed	JHD2C_HUMAN	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8)	JMJD1C JHDM2C KIAA1380 TRIP8	Homo sapiens (Human)	2540	FUNCTION: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 3]: May function as a tumor suppressor, reduced expression in breast cancer tumors. {ECO:0000305}.	blood coagulation [GO:0007596]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]	chromatin DNA binding [GO:0031490]; dioxygenase activity [GO:0051213]; histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; chromatin DNA binding [GO:0031490]; dioxygenase activity [GO:0051213]; histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966]; transcription coregulator activity [GO:0003712]; blood coagulation [GO:0007596]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q15653	reviewed	IKBB_HUMAN	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)	NFKBIB IKBB TRIP9	Homo sapiens (Human)	356	FUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.		cellular response to lipopolysaccharide [GO:0071222]; DNA-templated transcription [GO:0006351]; inflammatory response [GO:0006954]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]	cytosol [GO:0005829]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; cellular response to lipopolysaccharide [GO:0071222]; DNA-templated transcription [GO:0006351]; inflammatory response [GO:0006954]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q15654	reviewed	TRIP6_HUMAN	Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1)	TRIP6 OIP1	Homo sapiens (Human)	476	FUNCTION: Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}.		chordate embryonic development [GO:0043009]; focal adhesion assembly [GO:0048041]; positive regulation of cell migration [GO:0030335]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	interleukin-1 receptor binding [GO:0005149]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; interleukin-1 receptor binding [GO:0005149]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA binding [GO:0003723]; chordate embryonic development [GO:0043009]; focal adhesion assembly [GO:0048041]; positive regulation of cell migration [GO:0030335]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16624523}. Cell junction, focal adhesion {ECO:0000269|PubMed:16624523}. Nucleus {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:16624523}. Cytoplasm {ECO:0000269|PubMed:16624523}. Note=Shuttles between nucleus and cytoplasm (PubMed:16624523). Colocalizes with actin (PubMed:10826496). {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:16624523}.
Q15661	reviewed	TRYB1_HUMAN	Tryptase alpha/beta-1 (Tryptase-1) (EC 3.4.21.59) (Tryptase I) (Tryptase alpha-1)	TPSAB1 TPS1 TPS2 TPSB1	Homo sapiens (Human)	275	FUNCTION: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315). {ECO:0000250, ECO:0000250|UniProtKB:P21845, ECO:0000269|PubMed:18854315}.		defense response [GO:0006952]; extracellular matrix disassembly [GO:0022617]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; defense response [GO:0006952]; extracellular matrix disassembly [GO:0022617]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted. Note=Released from the secretory granules upon mast cell activation. {ECO:0000250}.
Q15669	reviewed	RHOH_HUMAN	Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)	RHOH ARHH TTF	Homo sapiens (Human)	191	FUNCTION: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils. {ECO:0000250, ECO:0000269|PubMed:11809807, ECO:0000269|PubMed:19414807, ECO:0000269|PubMed:22850876}.		actin filament organization [GO:0007015]; mast cell activation [GO:0045576]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of T cell differentiation [GO:0045582]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; T cell differentiation [GO:0030217]	cytoplasm [GO:0005737]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase inhibitor activity [GO:0005095]; kinase inhibitor activity [GO:0019210]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase inhibitor activity [GO:0005095]; kinase inhibitor activity [GO:0019210]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]; actin filament organization [GO:0007015]; mast cell activation [GO:0045576]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of T cell differentiation [GO:0045582]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11809807, ECO:0000269|PubMed:19414807}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes together with ZAP70 in the immunological synapse. {ECO:0000250}.
Q15672	reviewed	TWST1_HUMAN	Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist)	TWIST1 BHLHA38 TWIST	Homo sapiens (Human)	202	FUNCTION: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:P26687, ECO:0000269|PubMed:12553906, ECO:0000269|PubMed:25981568}.		aortic valve morphogenesis [GO:0003180]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell proliferation involved in heart valve development [GO:2000793]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hypoxia [GO:0071456]; cranial suture morphogenesis [GO:0060363]; developmental process [GO:0032502]; embryonic camera-type eye formation [GO:0060900]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cushion morphogenesis [GO:0003203]; energy homeostasis [GO:0097009]; eyelid development in camera-type eye [GO:0061029]; in utero embryonic development [GO:0001701]; mitral valve morphogenesis [GO:0003183]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; outer ear morphogenesis [GO:0042473]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation [GO:2000802]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of bone mineralization [GO:0030500]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; roof of mouth development [GO:0060021]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coregulator binding [GO:0001221]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coregulator binding [GO:0001221]; aortic valve morphogenesis [GO:0003180]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell proliferation involved in heart valve development [GO:2000793]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hypoxia [GO:0071456]; cranial suture morphogenesis [GO:0060363]; developmental process [GO:0032502]; embryonic camera-type eye formation [GO:0060900]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cushion morphogenesis [GO:0003203]; energy homeostasis [GO:0097009]; eyelid development in camera-type eye [GO:0061029]; in utero embryonic development [GO:0001701]; mitral valve morphogenesis [GO:0003183]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; outer ear morphogenesis [GO:0042473]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation [GO:2000802]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of bone mineralization [GO:0030500]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; roof of mouth development [GO:0060021]	SUBCELLULAR LOCATION: Nucleus.
Q15678	reviewed	PTN14_HUMAN	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)	PTPN14 PEZ PTPD2	Homo sapiens (Human)	1187	FUNCTION: Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}.		lymphangiogenesis [GO:0001946]; negative regulation of cell population proliferation [GO:0008285]; protein dephosphorylation [GO:0006470]; regulation of protein export from nucleus [GO:0046825]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; transcription coregulator activity [GO:0003712]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; transcription coregulator activity [GO:0003712]; lymphangiogenesis [GO:0001946]; negative regulation of cell population proliferation [GO:0008285]; protein dephosphorylation [GO:0006470]; regulation of protein export from nucleus [GO:0046825]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.
Q15691	reviewed	MARE1_HUMAN	Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)	MAPRE1	Homo sapiens (Human)	268	FUNCTION: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293}.		attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; cell migration [GO:0016477]; establishment of mitotic spindle orientation [GO:0000132]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; negative regulation of microtubule polymerization [GO:0031115]; non-motile cilium assembly [GO:1905515]; positive regulation of microtubule polymerization [GO:0031116]; protein localization [GO:0008104]; protein localization to astral microtubule [GO:1902888]; protein localization to centrosome [GO:0071539]; protein localization to microtubule [GO:0035372]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225]	cell projection membrane [GO:0031253]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cortical microtubule cytoskeleton [GO:0030981]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; mitotic spindle astral microtubule end [GO:1905721]; mitotic spindle pole [GO:0097431]; spindle midzone [GO:0051233]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; microtubule plus-end binding [GO:0051010]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]	cell projection membrane [GO:0031253]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cortical microtubule cytoskeleton [GO:0030981]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; mitotic spindle astral microtubule end [GO:1905721]; mitotic spindle pole [GO:0097431]; spindle midzone [GO:0051233]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; microtubule plus-end binding [GO:0051010]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; cell migration [GO:0016477]; establishment of mitotic spindle orientation [GO:0000132]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; negative regulation of microtubule polymerization [GO:0031115]; non-motile cilium assembly [GO:1905515]; positive regulation of microtubule polymerization [GO:0031116]; protein localization [GO:0008104]; protein localization to astral microtubule [GO:1902888]; protein localization to centrosome [GO:0071539]; protein localization to microtubule [GO:0035372]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10188731, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:9724749}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:14654843}. Golgi apparatus {ECO:0000269|PubMed:25217626}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23509069}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:34608293}. Note=Associated with the microtubule growing distal tips (PubMed:28814570). Recruitment to the Golgi apparatus requires the presence of PDE4DIP isoform 13/MMG8/SMYLE (PubMed:25217626). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:28814570}.
Q15696	reviewed	U2AFM_HUMAN	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP)	ZRSR2 U2AF1-RS2 U2AF1L2 U2AF1RS2 URP	Homo sapiens (Human)	482	FUNCTION: Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. {ECO:0000269|PubMed:21041408, ECO:0000269|PubMed:9237760}.		mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]	nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2AF complex [GO:0089701]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]	nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2AF complex [GO:0089701]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15146077}.
Q15697	reviewed	ZN174_HUMAN	Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8)	ZNF174 ZSCAN8	Homo sapiens (Human)	407	FUNCTION: Transcriptional repressor. {ECO:0000269|PubMed:7673192}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q15699	reviewed	ALX1_HUMAN	ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1)	ALX1 CART1	Homo sapiens (Human)	326	FUNCTION: Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:9753625, PubMed:8756334). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509). {ECO:0000269|PubMed:20451171, ECO:0000269|PubMed:23288509, ECO:0000269|PubMed:8756334, ECO:0000269|PubMed:9753625}.		embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8756334, ECO:0000269|PubMed:9753625}.
Q15700	reviewed	DLG2_HUMAN	Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)	DLG2	Homo sapiens (Human)	870	FUNCTION: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.		anterograde axonal protein transport [GO:0099641]; cell-cell adhesion [GO:0098609]; cellular response to potassium ion [GO:0035865]; chemical synaptic transmission [GO:0007268]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; retrograde axonal protein transport [GO:0099642]	adherens junction [GO:0005912]; axon cytoplasm [GO:1904115]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]	guanylate kinase activity [GO:0004385]; kinase binding [GO:0019900]	adherens junction [GO:0005912]; axon cytoplasm [GO:1904115]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; guanylate kinase activity [GO:0004385]; kinase binding [GO:0019900]; anterograde axonal protein transport [GO:0099641]; cell-cell adhesion [GO:0098609]; cellular response to potassium ion [GO:0035865]; chemical synaptic transmission [GO:0007268]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; retrograde axonal protein transport [GO:0099642]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q63622}; Lipid-anchor {ECO:0000250|UniProtKB:Q63622}. Postsynaptic density {ECO:0000250|UniProtKB:Q63622}. Synapse {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:Q63622}. Cell projection, axon {ECO:0000250|UniProtKB:Q63622}. Perikaryon {ECO:0000250|UniProtKB:Q63622}. Note=Concentrated in soma and postsynaptic density of a subset of neurons. {ECO:0000250|UniProtKB:Q63622}.
Q15714	reviewed	T22D1_HUMAN	TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein)	TSC22D1 KIAA1994 TGFB1I4 TSC22 hucep-2	Homo sapiens (Human)	1073	FUNCTION: Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). {ECO:0000250|UniProtKB:P62500, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:15881652, ECO:0000269|PubMed:18325344, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:26752201, ECO:0000269|PubMed:9022669}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000250|UniProtKB:P62500}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000250|UniProtKB:P62500}.		negative regulation of apoptotic process [GO:0043066]; negative regulation of hematopoietic stem cell proliferation [GO:1902034]; negative regulation of programmed cell death [GO:0043069]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of programmed cell death [GO:0043068]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hematopoietic stem cell proliferation [GO:1902034]; negative regulation of programmed cell death [GO:0043069]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of programmed cell death [GO:0043068]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21791611}. Nucleus {ECO:0000250|UniProtKB:P62500}. Cell membrane {ECO:0000269|PubMed:21791611}; Peripheral membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:34681573}. Nucleus {ECO:0000269|PubMed:34681573}. Mitochondrion {ECO:0000269|PubMed:34681573}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:34681573}. Nucleus {ECO:0000269|PubMed:34681573}. Mitochondrion {ECO:0000269|PubMed:34681573}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:34681573}. Nucleus {ECO:0000269|PubMed:34681573}.
Q15717	reviewed	ELAV1_HUMAN	ELAV-like protein 1 (Hu-antigen R) (HuR)	ELAVL1 HUR	Homo sapiens (Human)	326	FUNCTION: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}.		3'-UTR-mediated mRNA stabilization [GO:0070935]; mRNA stabilization [GO:0048255]; negative regulation of miRNA-mediated gene silencing [GO:0060965]; positive regulation of translation [GO:0045727]; post-transcriptional gene silencing [GO:0016441]; protein homooligomerization [GO:0051260]; protein import into nucleus [GO:0006606]; regulation of stem cell population maintenance [GO:2000036]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; postsynapse [GO:0098794]; ribonucleoprotein complex [GO:1990904]; sarcoplasm [GO:0016528]	double-stranded RNA binding [GO:0003725]; lncRNA binding [GO:0106222]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; postsynapse [GO:0098794]; ribonucleoprotein complex [GO:1990904]; sarcoplasm [GO:0016528]; double-stranded RNA binding [GO:0003725]; lncRNA binding [GO:0106222]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; mRNA stabilization [GO:0048255]; negative regulation of miRNA-mediated gene silencing [GO:0060965]; positive regulation of translation [GO:0045727]; post-transcriptional gene silencing [GO:0016441]; protein homooligomerization [GO:0051260]; protein import into nucleus [GO:0006606]; regulation of stem cell population maintenance [GO:2000036]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303}. Nucleus {ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P70372}. Cytoplasm, P-body {ECO:0000269|PubMed:29476152}. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288). Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462).Localizes to the stress granules in the presence of PLEKHN1 (By similarity). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:18285462}.
Q15722	reviewed	LT4R1_HUMAN	Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7)	LTB4R BLT BLT1 BLTR CMKRL1 GPR16 P2RY7	Homo sapiens (Human)	352	FUNCTION: Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.		G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; muscle contraction [GO:0006936]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; leukotriene B4 receptor activity [GO:0001632]; leukotriene receptor activity [GO:0004974]; nucleotide binding [GO:0000166]	plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; leukotriene B4 receptor activity [GO:0001632]; leukotriene receptor activity [GO:0004974]; nucleotide binding [GO:0000166]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; muscle contraction [GO:0006936]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q15723	reviewed	ELF2_HUMAN	ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor)	ELF2 NERF	Homo sapiens (Human)	593	FUNCTION: Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.; FUNCTION: Isoform 2 may function in repression of RUNX1-mediated transactivation.		negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q15726	reviewed	KISS1_HUMAN	Metastasis-suppressor KiSS-1 (Kisspeptin-1) [Cleaved into: Metastin (Kisspeptin-54); Kisspeptin-14; Kisspeptin-13; Kisspeptin-10]	KISS1 PP5098	Homo sapiens (Human)	138	FUNCTION: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. {ECO:0000269|PubMed:11060311, ECO:0000269|PubMed:11385580, ECO:0000269|PubMed:15500545, ECO:0000269|PubMed:9185708}.		cytoskeleton organization [GO:0007010]; G protein-coupled receptor signaling pathway [GO:0007186]; generation of ovulation cycle rhythm [GO:0060112]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of synaptic transmission [GO:0050806]	apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]	kisspeptin receptor binding [GO:0031773]	apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; kisspeptin receptor binding [GO:0031773]; cytoskeleton organization [GO:0007010]; G protein-coupled receptor signaling pathway [GO:0007186]; generation of ovulation cycle rhythm [GO:0060112]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of synaptic transmission [GO:0050806]	SUBCELLULAR LOCATION: Secreted.
Q15735	reviewed	PI5PA_HUMAN	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.36) (Inositol polyphosphate 5-phosphatase J) (Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase) (EC 3.1.3.56) (Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.56)	INPP5J PIB5PA PIPP	Homo sapiens (Human)	1006	FUNCTION: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. {ECO:0000250|UniProtKB:Q9JMC1}.		inositol phosphate metabolic process [GO:0043647]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; growth cone [GO:0030426]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; growth cone [GO:0030426]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; SH3 domain binding [GO:0017124]; inositol phosphate metabolic process [GO:0043647]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Predominantly localized to membrane ruffles. {ECO:0000250}.
Q15738	reviewed	NSDHL_HUMAN	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Protein H105e3)	NSDHL H105E3	Homo sapiens (Human)	373	FUNCTION: Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (By similarity). Also plays a role in the regulation of the endocytic trafficking of EGFR (By similarity). {ECO:0000250|UniProtKB:Q9R1J0}.		cholesterol biosynthetic process [GO:0006695]; cholesterol metabolic process [GO:0008203]; hair follicle development [GO:0001942]; labyrinthine layer blood vessel development [GO:0060716]; smoothened signaling pathway [GO:0007224]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]	3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity [GO:0102175]; 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity [GO:0103066]; 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity [GO:0103067]; C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity [GO:0000252]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity [GO:0047012]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; 3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity [GO:0102175]; 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity [GO:0103066]; 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity [GO:0103067]; C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity [GO:0000252]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity [GO:0047012]; cholesterol biosynthetic process [GO:0006695]; cholesterol metabolic process [GO:0008203]; hair follicle development [GO:0001942]; labyrinthine layer blood vessel development [GO:0060716]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21129721}; Single-pass membrane protein {ECO:0000255}. Lipid droplet {ECO:0000250|UniProtKB:Q9R1J0}. Note=Trafficking through the Golgi is necessary for ER membrane localization. {ECO:0000250|UniProtKB:Q9R1J0}.
Q15742	reviewed	NAB2_HUMAN	NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER)	NAB2 MADER	Homo sapiens (Human)	525	FUNCTION: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}.		endochondral ossification [GO:0001958]; myelination [GO:0042552]; negative regulation of transcription by RNA polymerase III [GO:0016480]; positive regulation of tau-protein kinase activity [GO:1902949]; regulation of DNA-templated transcription [GO:0006355]; regulation of epidermis development [GO:0045682]; Schwann cell differentiation [GO:0014037]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; endochondral ossification [GO:0001958]; myelination [GO:0042552]; negative regulation of transcription by RNA polymerase III [GO:0016480]; positive regulation of tau-protein kinase activity [GO:1902949]; regulation of DNA-templated transcription [GO:0006355]; regulation of epidermis development [GO:0045682]; Schwann cell differentiation [GO:0014037]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Isoform 2 is not localized to the nucleus. {ECO:0000250}.
Q15743	reviewed	OGR1_HUMAN	Ovarian cancer G-protein coupled receptor 1 (OGR-1) (G-protein coupled receptor 68) (GPR12A) (Sphingosylphosphorylcholine receptor)	GPR68 OGR1	Homo sapiens (Human)	365	FUNCTION: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity). {ECO:0000250, ECO:0000269|PubMed:12955148}.		cellular response to pH [GO:0071467]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; insulin secretion [GO:0030073]; monocyte differentiation [GO:0030224]; negative regulation of monocyte differentiation [GO:0045656]; osteoclast development [GO:0036035]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of osteoclast development [GO:2001206]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; cellular response to pH [GO:0071467]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; insulin secretion [GO:0030073]; monocyte differentiation [GO:0030224]; negative regulation of monocyte differentiation [GO:0045656]; osteoclast development [GO:0036035]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of osteoclast development [GO:2001206]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q15744	reviewed	CEBPE_HUMAN	CCAAT/enhancer-binding protein epsilon (C/EBP epsilon)	CEBPE	Homo sapiens (Human)	281	FUNCTION: Transcriptional activator (PubMed:26019275). C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588). {ECO:0000269|PubMed:10359588, ECO:0000269|PubMed:26019275}.		cellular response to lipopolysaccharide [GO:0071222]; defense response [GO:0006952]; DNA-templated transcription [GO:0006351]; granulocyte differentiation [GO:0030851]; integrated stress response signaling [GO:0140467]; macrophage differentiation [GO:0030225]; myeloid cell differentiation [GO:0030099]; phagocytosis [GO:0006909]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to lipopolysaccharide [GO:0071222]; defense response [GO:0006952]; DNA-templated transcription [GO:0006351]; granulocyte differentiation [GO:0030851]; integrated stress response signaling [GO:0140467]; macrophage differentiation [GO:0030225]; myeloid cell differentiation [GO:0030099]; phagocytosis [GO:0006909]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11313242, ECO:0000269|PubMed:26019275}.
Q15746	reviewed	MYLK_HUMAN	Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]	MYLK MLCK MLCK1 MYLK1	Homo sapiens (Human)	1914	FUNCTION: Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}.	MISCELLANEOUS: In asthmatic patients, overexpression promotes actin filament propulsion, thus contributing to airway hyperresponsiveness. Some MYLK variants may contribute to acute lung injury (ALI) susceptibility. Potential therapeutic target in the treatment of burn edema. {ECO:0000305|PubMed:19011151}.; MISCELLANEOUS: [Isoform 5]: Transcribed from an alternative promoter resulting in the usage of Met-923 as initiator codon. {ECO:0000269|PubMed:22015949}.; MISCELLANEOUS: [Isoform 6]: Transcribed from an alternative promoter resulting in the usage of Met-1761 as initiator codon. Has no catalytic activity. Initiator Met is removed. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Transcribed from an alternative promoter resulting in the usage of Met-1761 as initiator codon. Initiator Met is removed. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Transcribed from an alternative promoter resulting in the usage of Met-923 as initiator codon. {ECO:0000269|PubMed:22015949}.	aorta smooth muscle tissue morphogenesis [GO:0060414]; bleb assembly [GO:0032060]; cellular hypotonic response [GO:0071476]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of wound healing [GO:0090303]; protein phosphorylation [GO:0006468]; smooth muscle contraction [GO:0006939]; tonic smooth muscle contraction [GO:0014820]	actin cytoskeleton [GO:0015629]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	actin binding [GO:0003779]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; myosin light chain kinase activity [GO:0004687]	actin cytoskeleton [GO:0015629]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; actin binding [GO:0003779]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; myosin light chain kinase activity [GO:0004687]; aorta smooth muscle tissue morphogenesis [GO:0060414]; bleb assembly [GO:0032060]; cellular hypotonic response [GO:0071476]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of wound healing [GO:0090303]; protein phosphorylation [GO:0006468]; smooth muscle contraction [GO:0006939]; tonic smooth muscle contraction [GO:0014820]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20053363}. Cell projection, lamellipodium {ECO:0000269|PubMed:20053363}. Cleavage furrow {ECO:0000269|PubMed:15020676}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:15020676}. Note=Localized to stress fibers during interphase and to the cleavage furrow during mitosis. {ECO:0000269|PubMed:15020676}.
Q15750	reviewed	TAB1_HUMAN	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)	TAB1 MAP3K7IP1	Homo sapiens (Human)	504	FUNCTION: Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed:10838074, PubMed:25260751). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism (PubMed:14592977). Plays also a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (PubMed:18021073). {ECO:0000269|PubMed:10838074, ECO:0000269|PubMed:11847341, ECO:0000269|PubMed:14592977, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:22307082, ECO:0000269|PubMed:24403530, ECO:0000269|PubMed:25260751, ECO:0000269|PubMed:29229647}.	MISCELLANEOUS: [Isoform 2]: Does not bind nor activate MAP3K7/TAK1. {ECO:0000305}.	aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; nuclear speck [GO:0016607]; protein-containing complex [GO:0032991]	enzyme activator activity [GO:0008047]; kinase activator activity [GO:0019209]; mitogen-activated protein kinase p38 binding [GO:0048273]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; nuclear speck [GO:0016607]; protein-containing complex [GO:0032991]; enzyme activator activity [GO:0008047]; kinase activator activity [GO:0019209]; mitogen-activated protein kinase p38 binding [GO:0048273]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]; aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; transforming growth factor beta receptor signaling pathway [GO:0007179]	
Q15751	reviewed	HERC1_HUMAN	Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619)	HERC1	Homo sapiens (Human)	4861	FUNCTION: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.		autophagy [GO:0006914]; cerebellar Purkinje cell differentiation [GO:0021702]; corpus callosum development [GO:0022038]; negative regulation of autophagy [GO:0010507]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	guanyl-nucleotide exchange factor activity [GO:0005085]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; guanyl-nucleotide exchange factor activity [GO:0005085]; ubiquitin-protein transferase activity [GO:0004842]; autophagy [GO:0006914]; cerebellar Purkinje cell differentiation [GO:0021702]; corpus callosum development [GO:0022038]; negative regulation of autophagy [GO:0010507]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin-rich surface protrusions.
Q15758	reviewed	AAAT_HUMAN	Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5)	SLC1A5 ASCT2 M7V1 RDR RDRC	Homo sapiens (Human)	541	FUNCTION: Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:23756778, PubMed:26492990, PubMed:17094966, PubMed:34741534, PubMed:29872227, PubMed:8702519). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (PubMed:17094966). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). {ECO:0000250|UniProtKB:D3ZJ25, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:17094966, ECO:0000269|PubMed:23492904, ECO:0000269|PubMed:23756778, ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:26492990, ECO:0000269|PubMed:29872227, ECO:0000269|PubMed:32733894, ECO:0000269|PubMed:34741534, ECO:0000269|PubMed:8702519}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. {ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. {ECO:0000269|PubMed:10196349}.		amino acid transport [GO:0006865]; erythrocyte differentiation [GO:0030218]; glutamine secretion [GO:0010585]; glutamine transport [GO:0006868]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamine import across plasma membrane [GO:1903803]; neutral amino acid transport [GO:0015804]; protein homotrimerization [GO:0070207]; transport across blood-brain barrier [GO:0150104]	basal plasma membrane [GO:0009925]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamine transmembrane transporter activity [GO:0015186]; L-serine transmembrane transporter activity [GO:0015194]; ligand-gated channel activity [GO:0022834]; metal ion binding [GO:0046872]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; signaling receptor activity [GO:0038023]; symporter activity [GO:0015293]; virus receptor activity [GO:0001618]	basal plasma membrane [GO:0009925]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamine transmembrane transporter activity [GO:0015186]; L-serine transmembrane transporter activity [GO:0015194]; ligand-gated channel activity [GO:0022834]; metal ion binding [GO:0046872]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; signaling receptor activity [GO:0038023]; symporter activity [GO:0015293]; virus receptor activity [GO:0001618]; amino acid transport [GO:0006865]; erythrocyte differentiation [GO:0030218]; glutamine secretion [GO:0010585]; glutamine transport [GO:0006868]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamine import across plasma membrane [GO:1903803]; neutral amino acid transport [GO:0015804]; protein homotrimerization [GO:0070207]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:8702519, ECO:0000305|PubMed:29872227}; Multi-pass membrane protein {ECO:0000269|PubMed:29872227}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Q15759	reviewed	MK11_HUMAN	Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)	MAPK11 PRKM11 SAPK2 SAPK2B	Homo sapiens (Human)	364	FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors (PubMed:12452429, PubMed:20626350, PubMed:35857590). Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 functions are mostly redundant with those of MAPK14 (PubMed:12452429, PubMed:20626350, PubMed:35857590). Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets (PubMed:12452429, PubMed:20626350). RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:9430721, PubMed:10330143, PubMed:15356147). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers (PubMed:9430721, PubMed:10330143, PubMed:15356147). The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:15356147, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:12452429, ECO:0000303|PubMed:20626350}.		bone development [GO:0060348]; cardiac muscle cell proliferation [GO:0060038]; cellular response to interleukin-1 [GO:0071347]; cellular response to UV-B [GO:0071493]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; intracellular signal transduction [GO:0035556]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; osteoblast differentiation [GO:0001649]; p38MAPK cascade [GO:0038066]; phosphorylation [GO:0016310]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of muscle cell differentiation [GO:0051149]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; bone development [GO:0060348]; cardiac muscle cell proliferation [GO:0060038]; cellular response to interleukin-1 [GO:0071347]; cellular response to UV-B [GO:0071493]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; intracellular signal transduction [GO:0035556]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; osteoblast differentiation [GO:0001649]; p38MAPK cascade [GO:0038066]; phosphorylation [GO:0016310]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of muscle cell differentiation [GO:0051149]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q15761	reviewed	NPY5R_HUMAN	Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor)	NPY5R NPYR5	Homo sapiens (Human)	445	FUNCTION: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.		cardiac left ventricle morphogenesis [GO:0003214]; chemical synaptic transmission [GO:0007268]; eating behavior [GO:0042755]; G protein-coupled receptor signaling pathway [GO:0007186]; generation of ovulation cycle rhythm [GO:0060112]; negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; outflow tract morphogenesis [GO:0003151]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of smooth muscle cell proliferation [GO:0048661]; synaptic signaling via neuropeptide [GO:0099538]	GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	neuropeptide binding [GO:0042923]; neuropeptide Y receptor activity [GO:0004983]; pancreatic polypeptide receptor activity [GO:0001602]; peptide YY receptor activity [GO:0001601]	GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; neuropeptide binding [GO:0042923]; neuropeptide Y receptor activity [GO:0004983]; pancreatic polypeptide receptor activity [GO:0001602]; peptide YY receptor activity [GO:0001601]; cardiac left ventricle morphogenesis [GO:0003214]; chemical synaptic transmission [GO:0007268]; eating behavior [GO:0042755]; G protein-coupled receptor signaling pathway [GO:0007186]; generation of ovulation cycle rhythm [GO:0060112]; negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; outflow tract morphogenesis [GO:0003151]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of smooth muscle cell proliferation [GO:0048661]; synaptic signaling via neuropeptide [GO:0099538]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q15762	reviewed	CD226_HUMAN	CD226 antigen (DNAX accessory molecule 1) (DNAM-1) (CD antigen CD226)	CD226 DNAM1	Homo sapiens (Human)	336	FUNCTION: Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:8673704}.		cell adhesion [GO:0007155]; cell recognition [GO:0008037]; positive regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060369]; positive regulation of immunoglobulin mediated immune response [GO:0002891]; positive regulation of mast cell activation [GO:0033005]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]; cell adhesion [GO:0007155]; cell recognition [GO:0008037]; positive regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060369]; positive regulation of immunoglobulin mediated immune response [GO:0002891]; positive regulation of mast cell activation [GO:0033005]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q15768	reviewed	EFNB3_HUMAN	Ephrin-B3 (EPH-related receptor transmembrane ligand ELK-L3) (EPH-related receptor tyrosine kinase ligand 8) (LERK-8)	EFNB3 EPLG8 LERK8	Homo sapiens (Human)	340	FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.; FUNCTION: (Microbial infection) Acts as a receptor for nipah virus and hendra virus. {ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}.		adult walking behavior [GO:0007628]; axon choice point recognition [GO:0016198]; axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of axonogenesis [GO:0050771]; nervous system development [GO:0007399]; positive regulation of presynapse assembly [GO:1905608]; positive regulation of synaptic transmission [GO:0050806]; T cell costimulation [GO:0031295]; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission [GO:0099557]	glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]	ephrin receptor binding [GO:0046875]; transmembrane-ephrin receptor activity [GO:0005005]; virus receptor activity [GO:0001618]	glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; ephrin receptor binding [GO:0046875]; transmembrane-ephrin receptor activity [GO:0005005]; virus receptor activity [GO:0001618]; adult walking behavior [GO:0007628]; axon choice point recognition [GO:0016198]; axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of axonogenesis [GO:0050771]; nervous system development [GO:0007399]; positive regulation of presynapse assembly [GO:1905608]; positive regulation of synaptic transmission [GO:0050806]; T cell costimulation [GO:0031295]; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission [GO:0099557]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q15771	reviewed	RAB30_HUMAN	Ras-related protein Rab-30	RAB30	Homo sapiens (Human)	203	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. {ECO:0000250, ECO:0000269|PubMed:22188167}.		Golgi organization [GO:0007030]; Rab protein signal transduction [GO:0032482]; vesicle-mediated transport [GO:0016192]	cis-Golgi network [GO:0005801]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network [GO:0005802]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cis-Golgi network [GO:0005801]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network [GO:0005802]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; Golgi organization [GO:0007030]; Rab protein signal transduction [GO:0032482]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:22188167}. Cytoplasm {ECO:0000269|PubMed:22188167}. Golgi apparatus {ECO:0000269|PubMed:22188167}.
Q15772	reviewed	SPEG_HUMAN	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1)	SPEG APEG1 KIAA1297	Homo sapiens (Human)	3267	FUNCTION: Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.	MISCELLANEOUS: Expression is under the tight control of the locus control region (LCRs).; MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 1]: Produced by alternative splicing. {ECO:0000305}.	muscle cell differentiation [GO:0042692]; muscle organ development [GO:0007517]; negative regulation of cell population proliferation [GO:0008285]; phosphorylation [GO:0016310]	nucleus [GO:0005634]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	nucleus [GO:0005634]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; muscle cell differentiation [GO:0042692]; muscle organ development [GO:0007517]; negative regulation of cell population proliferation [GO:0008285]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: [Isoform 3]: Nucleus.
Q15776	reviewed	ZKSC8_HUMAN	Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (Zinc finger protein 192)	ZKSCAN8 ZNF192	Homo sapiens (Human)	578	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q15777	reviewed	MPPD2_HUMAN	Metallophosphoesterase MPPED2 (EC 3.1.-.-) (Fetal brain protein 239) (239FB) (Metallophosphoesterase domain-containing protein 2)	MPPED2 C11orf8 FAM1B	Homo sapiens (Human)	294	FUNCTION: Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system. {ECO:0000250|UniProtKB:B1WBP0}.				AMP binding [GO:0016208]; GMP binding [GO:0019002]; manganese ion binding [GO:0030145]; phosphoric diester hydrolase activity [GO:0008081]	AMP binding [GO:0016208]; GMP binding [GO:0019002]; manganese ion binding [GO:0030145]; phosphoric diester hydrolase activity [GO:0008081]	
Q15782	reviewed	CH3L2_HUMAN	Chitinase-3-like protein 2 (Chondrocyte protein 39) (YKL-39)	CHI3L2	Homo sapiens (Human)	390	FUNCTION: Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. {ECO:0000269|PubMed:22742450}.		carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	carbohydrate binding [GO:0030246]; chitin binding [GO:0008061]; hydrolase activity [GO:0016787]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; carbohydrate binding [GO:0030246]; chitin binding [GO:0008061]; hydrolase activity [GO:0016787]; carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q15784	reviewed	NDF2_HUMAN	Neurogenic differentiation factor 2 (NeuroD2) (Class A basic helix-loop-helix protein 1) (bHLHa1) (NeuroD-related factor) (NDRF)	NEUROD2 BHLHA1 NDRF	Homo sapiens (Human)	382	FUNCTION: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity). {ECO:0000250}.		associative learning [GO:0008306]; axon development [GO:0061564]; behavioral fear response [GO:0001662]; cellular response to calcium ion [GO:0071277]; cellular response to electrical stimulus [GO:0071257]; cerebellar cortex development [GO:0021695]; negative regulation of synapse maturation [GO:2000297]; nervous system development [GO:0007399]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory organ development [GO:0007423]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein heterodimerization activity [GO:0046982]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein heterodimerization activity [GO:0046982]; sequence-specific double-stranded DNA binding [GO:1990837]; associative learning [GO:0008306]; axon development [GO:0061564]; behavioral fear response [GO:0001662]; cellular response to calcium ion [GO:0071277]; cellular response to electrical stimulus [GO:0071257]; cerebellar cortex development [GO:0021695]; negative regulation of synapse maturation [GO:2000297]; nervous system development [GO:0007399]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory organ development [GO:0007423]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q15785	reviewed	TOM34_HUMAN	Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit)	TOMM34 URCC3	Homo sapiens (Human)	309	FUNCTION: Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}.		protein targeting to mitochondrion [GO:0006626]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	heat shock protein binding [GO:0031072]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; heat shock protein binding [GO:0031072]; protein targeting to mitochondrion [GO:0006626]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10101285}. Mitochondrion outer membrane {ECO:0000269|PubMed:10101285}; Peripheral membrane protein {ECO:0000269|PubMed:10101285}; Cytoplasmic side {ECO:0000269|PubMed:10101285}.
Q15788	reviewed	NCOA1_HUMAN	Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)	NCOA1 BHLHE74 SRC1	Homo sapiens (Human)	1441	FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}.	MISCELLANEOUS: [Isoform 2]: Major form. Contains a domain at its C-terminus (1241-1399) that is able to mediate transactivation. {ECO:0000305}.	cellular response to hormone stimulus [GO:0032870]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; estrous cycle [GO:0044849]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; labyrinthine layer morphogenesis [GO:0060713]; lactation [GO:0007595]; male gonad development [GO:0008584]; male mating behavior [GO:0060179]; mRNA transcription by RNA polymerase II [GO:0042789]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of female receptivity [GO:0045925]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by galactose [GO:0000435]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of thyroid hormone mediated signaling pathway [GO:0002155]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; histone acetyltransferase activity [GO:0004402]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoid X receptor binding [GO:0046965]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; histone acetyltransferase activity [GO:0004402]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoid X receptor binding [GO:0046965]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713]; cellular response to hormone stimulus [GO:0032870]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; estrous cycle [GO:0044849]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; labyrinthine layer morphogenesis [GO:0060713]; lactation [GO:0007595]; male gonad development [GO:0008584]; male mating behavior [GO:0060179]; mRNA transcription by RNA polymerase II [GO:0042789]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of female receptivity [GO:0045925]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by galactose [GO:0000435]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of thyroid hormone mediated signaling pathway [GO:0002155]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q15796	reviewed	SMAD2_HUMAN	Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)	SMAD2 MADH2 MADR2	Homo sapiens (Human)	467	FUNCTION: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}.		activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; DNA-templated transcription [GO:0006351]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic foregut morphogenesis [GO:0048617]; endocardial cushion morphogenesis [GO:0003203]; endoderm formation [GO:0001706]; gastrulation [GO:0007369]; in utero embryonic development [GO:0001701]; insulin secretion [GO:0030073]; intracellular signal transduction [GO:0035556]; lung development [GO:0030324]; mesoderm formation [GO:0001707]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; nodal signaling pathway [GO:0038092]; odontoblast differentiation [GO:0071895]; organ growth [GO:0035265]; pancreas development [GO:0031016]; paraxial mesoderm morphogenesis [GO:0048340]; pericardium development [GO:0060039]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; primary miRNA processing [GO:0031053]; pulmonary valve morphogenesis [GO:0003184]; regulation of binding [GO:0051098]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to cholesterol [GO:0070723]; response to glucose [GO:0009749]; secondary palate development [GO:0062009]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; zygotic specification of dorsal/ventral axis [GO:0007352]	activin responsive factor complex [GO:0032444]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SMAD protein complex [GO:0071141]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; co-SMAD binding [GO:0070410]; disordered domain specific binding [GO:0097718]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; tau protein binding [GO:0048156]; transforming growth factor beta receptor binding [GO:0005160]; type I transforming growth factor beta receptor binding [GO:0034713]; ubiquitin protein ligase binding [GO:0031625]	activin responsive factor complex [GO:0032444]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SMAD protein complex [GO:0071141]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; co-SMAD binding [GO:0070410]; disordered domain specific binding [GO:0097718]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; tau protein binding [GO:0048156]; transforming growth factor beta receptor binding [GO:0005160]; type I transforming growth factor beta receptor binding [GO:0034713]; ubiquitin protein ligase binding [GO:0031625]; activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; DNA-templated transcription [GO:0006351]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic foregut morphogenesis [GO:0048617]; endocardial cushion morphogenesis [GO:0003203]; endoderm formation [GO:0001706]; gastrulation [GO:0007369]; in utero embryonic development [GO:0001701]; insulin secretion [GO:0030073]; intracellular signal transduction [GO:0035556]; lung development [GO:0030324]; mesoderm formation [GO:0001707]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; nodal signaling pathway [GO:0038092]; odontoblast differentiation [GO:0071895]; organ growth [GO:0035265]; pancreas development [GO:0031016]; paraxial mesoderm morphogenesis [GO:0048340]; pericardium development [GO:0060039]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; primary miRNA processing [GO:0031053]; pulmonary valve morphogenesis [GO:0003184]; regulation of binding [GO:0051098]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to cholesterol [GO:0070723]; response to glucose [GO:0009749]; secondary palate development [GO:0062009]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; zygotic specification of dorsal/ventral axis [GO:0007352]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:9865696}. Nucleus {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:21599657, ECO:0000269|PubMed:22781750, ECO:0000269|PubMed:9865696}. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 (PubMed:9865696, PubMed:21145499). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:9865696}.
Q15797	reviewed	SMAD1_HUMAN	Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)	SMAD1 BSP1 MADH1 MADR1	Homo sapiens (Human)	465	FUNCTION: Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}.		anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cardiac conduction system development [GO:0003161]; cardiac muscle cell proliferation [GO:0060038]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cellular response to organic cyclic compound [GO:0071407]; embryonic pattern specification [GO:0009880]; gamete generation [GO:0007276]; hindbrain development [GO:0030902]; homeostatic process [GO:0042592]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; mesodermal cell fate commitment [GO:0001710]; midbrain development [GO:0030901]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of muscle cell differentiation [GO:0051148]; ossification [GO:0001503]; osteoblast fate commitment [GO:0002051]; positive regulation of cartilage development [GO:0061036]; positive regulation of gene expression [GO:0010628]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; primary miRNA processing [GO:0031053]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; homomeric SMAD protein complex [GO:0071142]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SMAD protein complex [GO:0071141]	co-SMAD binding [GO:0070410]; DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; homomeric SMAD protein complex [GO:0071142]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SMAD protein complex [GO:0071141]; co-SMAD binding [GO:0070410]; DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin protein ligase binding [GO:0031625]; anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cardiac conduction system development [GO:0003161]; cardiac muscle cell proliferation [GO:0060038]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cellular response to organic cyclic compound [GO:0071407]; embryonic pattern specification [GO:0009880]; gamete generation [GO:0007276]; hindbrain development [GO:0030902]; homeostatic process [GO:0042592]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; mesodermal cell fate commitment [GO:0001710]; midbrain development [GO:0030901]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of muscle cell differentiation [GO:0051148]; ossification [GO:0001503]; osteoblast fate commitment [GO:0002051]; positive regulation of cartilage development [GO:0061036]; positive regulation of gene expression [GO:0010628]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; primary miRNA processing [GO:0031053]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15647271, ECO:0000269|PubMed:9335504}. Nucleus {ECO:0000269|PubMed:15647271, ECO:0000269|PubMed:22781750, ECO:0000269|PubMed:9335504}. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:15647271}.
Q15800	reviewed	MSMO1_HUMAN	Methylsterol monooxygenase 1 (EC 1.14.18.9) (C-4 methylsterol oxidase) (Sterol-C4-methyl oxidase)	MSMO1 DESP4 ERG25 SC4MOL	Homo sapiens (Human)	293	FUNCTION: Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol (PubMed:21285510, PubMed:28673550, PubMed:23583456, PubMed:26114596). Also involved in drug metabolism, as it can metabolize eldecalcitol (ED-71 or 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol), a second-generation vitamin D analog, into 1alpha,2beta,25-trihydroxy vitamin D3; this reaction occurs via enzymatic hydroxylation and spontaneous O-dehydroxypropylation (PubMed:26038696). {ECO:0000269|PubMed:21285510, ECO:0000269|PubMed:26038696, ECO:0000269|PubMed:28673550, ECO:0000305|PubMed:23583456, ECO:0000305|PubMed:26114596}.		cholesterol biosynthetic process [GO:0006695]; fatty acid metabolic process [GO:0006631]; steroid metabolic process [GO:0008202]; sterol biosynthetic process [GO:0016126]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	C-4 methylsterol oxidase activity [GO:0000254]; iron ion binding [GO:0005506]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; C-4 methylsterol oxidase activity [GO:0000254]; iron ion binding [GO:0005506]; cholesterol biosynthetic process [GO:0006695]; fatty acid metabolic process [GO:0006631]; steroid metabolic process [GO:0008202]; sterol biosynthetic process [GO:0016126]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q15811	reviewed	ITSN1_HUMAN	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)	ITSN1 ITSN SH3D1A	Homo sapiens (Human)	1721	FUNCTION: Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250|UniProtKB:Q9Z0R4}.	MISCELLANEOUS: [Isoform 6]: Contains a premature stop codon, potentially subjected to NMD. {ECO:0000305}.; MISCELLANEOUS: [Isoform 13]: Contains a premature stop codon, potentially subjected to NMD. {ECO:0000305}.	clathrin-dependent synaptic vesicle endocytosis [GO:0150007]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; intracellular signal transduction [GO:0035556]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of small GTPase mediated signal transduction [GO:0051056]	clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular vesicle [GO:0097708]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; recycling endosome [GO:0055037]	calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064]	clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular vesicle [GO:0097708]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; recycling endosome [GO:0055037]; calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064]; clathrin-dependent synaptic vesicle endocytosis [GO:0150007]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; intracellular signal transduction [GO:0035556]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:11744688}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q9WVE9}. Cell projection, lamellipodium {ECO:0000269|PubMed:11744688}. Cell membrane {ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:20946875}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:20946875, ECO:0000269|PubMed:29887380}. Recycling endosome {ECO:0000269|PubMed:29030480}. Endosome {ECO:0000250|UniProtKB:Q9Z0R4}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9Z0R4}. Note=Colocalizes with SGIP1 at the plasma membrane in structures corresponding most probably to clathrin-coated pits (PubMed:20946875). Colocalizes with RAB13 on cytoplasmic vesicles that are most likely recycling endosomes (PubMed:29030480). {ECO:0000269|PubMed:20946875, ECO:0000269|PubMed:29030480}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:29599122}. Endomembrane system {ECO:0000269|PubMed:21712076}. Nucleus envelope {ECO:0000269|PubMed:29599122}. Note=Shuttles between the cytoplasm and nucleus in an XPO1/CRM1-dependent manner. {ECO:0000269|PubMed:29599122}.; SUBCELLULAR LOCATION: [Isoform 5]: Endomembrane system {ECO:0000269|PubMed:21712076}.
Q15813	reviewed	TBCE_HUMAN	Tubulin-specific chaperone E (Tubulin-folding cofactor E)	TBCE	Homo sapiens (Human)	527	FUNCTION: Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network. {ECO:0000269|PubMed:11847227, ECO:0000269|PubMed:27666369}.		adult locomotory behavior [GO:0008344]; developmental growth [GO:0048589]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; muscle atrophy [GO:0014889]; peripheral nervous system neuron axonogenesis [GO:0048936]; post-chaperonin tubulin folding pathway [GO:0007023]; post-embryonic development [GO:0009791]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]	cytoplasm [GO:0005737]; microtubule [GO:0005874]	alpha-tubulin binding [GO:0043014]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; alpha-tubulin binding [GO:0043014]; protein-folding chaperone binding [GO:0051087]; adult locomotory behavior [GO:0008344]; developmental growth [GO:0048589]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; muscle atrophy [GO:0014889]; peripheral nervous system neuron axonogenesis [GO:0048936]; post-chaperonin tubulin folding pathway [GO:0007023]; post-embryonic development [GO:0009791]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Q15814	reviewed	TBCC_HUMAN	Tubulin-specific chaperone C (Tubulin-folding cofactor C) (CFC)	TBCC	Homo sapiens (Human)	346	FUNCTION: Tubulin-folding protein; involved in the final step of the tubulin folding pathway. {ECO:0000269|PubMed:11847227}.		post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule [GO:0005874]; photoreceptor connecting cilium [GO:0032391]	GTPase activity [GO:0003924]; protein-folding chaperone binding [GO:0051087]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule [GO:0005874]; photoreceptor connecting cilium [GO:0032391]; GTPase activity [GO:0003924]; protein-folding chaperone binding [GO:0051087]; tubulin binding [GO:0015631]; post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12417528}. Note=Detected predominantly in the photoreceptor connecting cilium.
Q15818	reviewed	NPTX1_HUMAN	Neuronal pentraxin-1 (NP1) (Neuronal pentraxin I) (NP-I)	NPTX1	Homo sapiens (Human)	432	FUNCTION: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. {ECO:0000250|UniProtKB:P47971}.		axonogenesis involved in innervation [GO:0060385]; cellular response to glucose stimulus [GO:0071333]; cellular response to potassium ion [GO:0035865]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial transport [GO:0006839]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]	endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; synaptic cleft [GO:0043083]; transport vesicle [GO:0030133]	metal ion binding [GO:0046872]	endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; synaptic cleft [GO:0043083]; transport vesicle [GO:0030133]; metal ion binding [GO:0046872]; axonogenesis involved in innervation [GO:0060385]; cellular response to glucose stimulus [GO:0071333]; cellular response to potassium ion [GO:0035865]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial transport [GO:0006839]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34788392}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:34788392, ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:34788392, ECO:0000305}.
Q15819	reviewed	UB2V2_HUMAN	Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)	UBE2V2 MMS2 UEV2	Homo sapiens (Human)	145	FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. {ECO:0000269|PubMed:10089880, ECO:0000269|PubMed:14562038, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:9705497}.		DNA double-strand break processing [GO:0000729]; error-free postreplication DNA repair [GO:0042275]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; postreplication repair [GO:0006301]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA repair [GO:0006282]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; UBC13-MMS2 complex [GO:0031372]		cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; UBC13-MMS2 complex [GO:0031372]; DNA double-strand break processing [GO:0000729]; error-free postreplication DNA repair [GO:0042275]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; postreplication repair [GO:0006301]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA repair [GO:0006282]	
Q15822	reviewed	ACHA2_HUMAN	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	Homo sapiens (Human)	529	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.		cellular response to nicotine [GO:0071316]; modulation of inhibitory postsynaptic potential [GO:0098828]; monoatomic ion transport [GO:0006811]; response to acetylcholine [GO:1905144]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated channel complex [GO:0005892]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuron projection cytoplasm [GO:0120111]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; heterocyclic compound binding [GO:1901363]; quaternary ammonium group binding [GO:0050997]	acetylcholine-gated channel complex [GO:0005892]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuron projection cytoplasm [GO:0120111]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; heterocyclic compound binding [GO:1901363]; quaternary ammonium group binding [GO:0050997]; cellular response to nicotine [GO:0071316]; modulation of inhibitory postsynaptic potential [GO:0098828]; monoatomic ion transport [GO:0006811]; response to acetylcholine [GO:1905144]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Q15825	reviewed	ACHA6_HUMAN	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	Homo sapiens (Human)	494	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.		chemical synaptic transmission [GO:0007268]; membrane depolarization [GO:0051899]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; chemical synaptic transmission [GO:0007268]; membrane depolarization [GO:0051899]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Q15828	reviewed	CYTM_HUMAN	Cystatin-M (Cystatin-6) (Cystatin-E)	CST6	Homo sapiens (Human)	149	FUNCTION: High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain (PubMed:30425301). Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance (PubMed:30425301). {ECO:0000269|PubMed:30425301}.		anatomical structure morphogenesis [GO:0009653]; epidermis development [GO:0008544]	cornified envelope [GO:0001533]; extracellular exosome [GO:0070062]	cysteine-type endopeptidase inhibitor activity [GO:0004869]	cornified envelope [GO:0001533]; extracellular exosome [GO:0070062]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; anatomical structure morphogenesis [GO:0009653]; epidermis development [GO:0008544]	SUBCELLULAR LOCATION: Secreted.
Q15831	reviewed	STK11_HUMAN	Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)	STK11 LKB1 PJS	Homo sapiens (Human)	433	FUNCTION: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:11430832, ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15016379, ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}.; FUNCTION: [Isoform 2]: Has a role in spermiogenesis. {ECO:0000250}.		activation of protein kinase activity [GO:0032147]; anoikis [GO:0043276]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; cellular response to UV-B [GO:0071493]; dendrite extension [GO:0097484]; DNA damage response [GO:0006974]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; establishment of cell polarity [GO:0030010]; G1 to G0 transition [GO:0070314]; glucose homeostasis [GO:0042593]; Golgi localization [GO:0051645]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of TORC1 signaling [GO:1904262]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagy [GO:0010508]; positive regulation of axonogenesis [GO:0050772]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of vesicle transport along microtubule [GO:1901610]; positive thymic T cell selection [GO:0045059]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470]; protein localization to nucleus [GO:0034504]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of dendrite morphogenesis [GO:0048814]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of Wnt signaling pathway [GO:0030111]; response to activity [GO:0014823]; response to glucagon [GO:0033762]; response to ionizing radiation [GO:0010212]; response to lipid [GO:0033993]; response to thyroid hormone [GO:0097066]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]; tissue homeostasis [GO:0001894]; vasculature development [GO:0001944]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular protein-containing complex [GO:0140535]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554]; Z disc [GO:0030018]	ATP binding [GO:0005524]; LRR domain binding [GO:0030275]; magnesium ion binding [GO:0000287]; p53 binding [GO:0002039]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular protein-containing complex [GO:0140535]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554]; Z disc [GO:0030018]; ATP binding [GO:0005524]; LRR domain binding [GO:0030275]; magnesium ion binding [GO:0000287]; p53 binding [GO:0002039]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; activation of protein kinase activity [GO:0032147]; anoikis [GO:0043276]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; cellular response to UV-B [GO:0071493]; dendrite extension [GO:0097484]; DNA damage response [GO:0006974]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; establishment of cell polarity [GO:0030010]; G1 to G0 transition [GO:0070314]; glucose homeostasis [GO:0042593]; Golgi localization [GO:0051645]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of TORC1 signaling [GO:1904262]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagy [GO:0010508]; positive regulation of axonogenesis [GO:0050772]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of vesicle transport along microtubule [GO:1901610]; positive thymic T cell selection [GO:0045059]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470]; protein localization to nucleus [GO:0034504]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of dendrite morphogenesis [GO:0048814]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of Wnt signaling pathway [GO:0030111]; response to activity [GO:0014823]; response to glucagon [GO:0033762]; response to ionizing radiation [GO:0010212]; response to lipid [GO:0033993]; response to thyroid hormone [GO:0097066]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]; tissue homeostasis [GO:0001894]; vasculature development [GO:0001944]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Membrane {ECO:0000250}. Mitochondrion. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. PTEN promotes cytoplasmic localization. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:23612973}. Cytoplasm {ECO:0000269|PubMed:23612973}. Note=Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.
Q15833	reviewed	STXB2_HUMAN	Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B)	STXBP2 UNC18B	Homo sapiens (Human)	593	FUNCTION: Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. {ECO:0000269|PubMed:19804848, ECO:0000269|PubMed:19884660}.		intracellular protein transport [GO:0006886]; leukocyte mediated cytotoxicity [GO:0001909]; neurotransmitter secretion [GO:0007269]; neutrophil degranulation [GO:0043312]; regulation of mast cell degranulation [GO:0043304]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192]	azurophil granule [GO:0042582]; cytolytic granule [GO:0044194]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; secretory granule [GO:0030141]; specific granule [GO:0042581]; tertiary granule [GO:0070820]	syntaxin-1 binding [GO:0017075]; syntaxin-3 binding [GO:0030348]	azurophil granule [GO:0042582]; cytolytic granule [GO:0044194]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; secretory granule [GO:0030141]; specific granule [GO:0042581]; tertiary granule [GO:0070820]; syntaxin-1 binding [GO:0017075]; syntaxin-3 binding [GO:0030348]; intracellular protein transport [GO:0006886]; leukocyte mediated cytotoxicity [GO:0001909]; neurotransmitter secretion [GO:0007269]; neutrophil degranulation [GO:0043312]; regulation of mast cell degranulation [GO:0043304]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192]	
Q15834	reviewed	CC85B_HUMAN	Coiled-coil domain-containing protein 85B (Hepatitis delta antigen-interacting protein A) (Delta-interacting protein A)	CCDC85B DIPA	Homo sapiens (Human)	202	FUNCTION: Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). {ECO:0000250|UniProtKB:A2CEM9, ECO:0000250|UniProtKB:Q6PDY0, ECO:0000269|PubMed:17014843, ECO:0000269|PubMed:17873903}.; FUNCTION: (Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication. {ECO:0000269|PubMed:8810253}.	MISCELLANEOUS: May be the cellular homolog of HDAG. Overexpression inhibited HDV replication, whereas overexpression of HDAG reversed the inhibition, suggesting that HDAG may assist HDV replication by forming a complex with DIPA.	cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]	adherens junction [GO:0005912]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	delta-catenin binding [GO:0070097]	adherens junction [GO:0005912]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; delta-catenin binding [GO:0070097]; cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17014843, ECO:0000269|PubMed:17873903}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17014843}. Cell junction, adherens junction {ECO:0000269|PubMed:25009281}.
Q15835	reviewed	GRK1_HUMAN	Rhodopsin kinase GRK1 (RK) (EC 2.7.11.14) (G protein-coupled receptor kinase 1)	GRK1 RHOK	Homo sapiens (Human)	563	FUNCTION: Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity). {ECO:0000250|UniProtKB:Q9WVL4, ECO:0000269|PubMed:15946941}.		protein autophosphorylation [GO:0046777]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; regulation of signal transduction [GO:0009966]; rhodopsin mediated signaling pathway [GO:0016056]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; photoreceptor disc membrane [GO:0097381]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; rhodopsin kinase activity [GO:0050254]	cytoplasm [GO:0005737]; photoreceptor disc membrane [GO:0097381]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; rhodopsin kinase activity [GO:0050254]; protein autophosphorylation [GO:0046777]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; regulation of signal transduction [GO:0009966]; rhodopsin mediated signaling pathway [GO:0016056]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P28327}; Lipid-anchor {ECO:0000250|UniProtKB:P28327}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9WVL4}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000250|UniProtKB:Q9WVL4}.
Q15836	reviewed	VAMP3_HUMAN	Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3)	VAMP3 SYB3	Homo sapiens (Human)	100	FUNCTION: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}.		calcium-ion regulated exocytosis [GO:0017156]; cellular response to type II interferon [GO:0071346]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; membrane fusion [GO:0061025]; negative regulation of secretion by cell [GO:1903531]; positive regulation of receptor recycling [GO:0001921]; protein-containing complex assembly [GO:0065003]; retrograde transport, endosome to Golgi [GO:0042147]; SNARE complex assembly [GO:0035493]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule [GO:0030141]; SNARE complex [GO:0031201]; synapse [GO:0045202]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]	SNAP receptor activity [GO:0005484]; syntaxin-1 binding [GO:0017075]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule [GO:0030141]; SNARE complex [GO:0031201]; synapse [GO:0045202]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; SNAP receptor activity [GO:0005484]; syntaxin-1 binding [GO:0017075]; calcium-ion regulated exocytosis [GO:0017156]; cellular response to type II interferon [GO:0071346]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; membrane fusion [GO:0061025]; negative regulation of secretion by cell [GO:1903531]; positive regulation of receptor recycling [GO:0001921]; protein-containing complex assembly [GO:0065003]; retrograde transport, endosome to Golgi [GO:0042147]; SNARE complex assembly [GO:0035493]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:23353890}; Single-pass type IV membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:23353890}; Single-pass type I membrane protein {ECO:0000255}. Synapse, synaptosome {ECO:0000305}.
Q15842	reviewed	KCNJ8_HUMAN	ATP-sensitive inward rectifier potassium channel 8 (Inward rectifier K(+) channel Kir6.1) (Potassium channel, inwardly rectifying subfamily J member 8) (uKATP-1)	KCNJ8	Homo sapiens (Human)	424	FUNCTION: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). {ECO:0000250|UniProtKB:Q63664, ECO:0000269|PubMed:28842488}.		adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; atrioventricular node cell differentiation [GO:0060922]; calcium ion transmembrane transport [GO:0070588]; CAMKK-AMPK signaling cascade [GO:0061762]; coronary vasculature development [GO:0060976]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; establishment of cell polarity [GO:0030010]; fat cell differentiation [GO:0045444]; fatty acid transport [GO:0015908]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; glutamate secretion, neurotransmission [GO:0061535]; heart morphogenesis [GO:0003007]; inorganic cation transmembrane transport [GO:0098662]; kidney development [GO:0001822]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; microglial cell activation [GO:0001774]; neuromuscular process [GO:0050905]; NLRP3 inflammasome complex assembly [GO:0044546]; p38MAPK cascade [GO:0038066]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein secretion [GO:0009306]; reactive gliosis [GO:0150103]; regulation of blood pressure [GO:0008217]; regulation of heart rate [GO:0002027]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to ATP [GO:0033198]; response to cytokine [GO:0034097]; response to endoplasmic reticulum stress [GO:0034976]; response to exogenous dsRNA [GO:0043330]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to resveratrol [GO:1904638]; response to xenobiotic stimulus [GO:0009410]; synaptic assembly at neuromuscular junction [GO:0051124]; transmission of nerve impulse [GO:0019226]; transport across blood-brain barrier [GO:0150104]; vasodilation [GO:0042311]; ventricular cardiac muscle tissue development [GO:0003229]	glutamatergic synapse [GO:0098978]; inward rectifying potassium channel [GO:0008282]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; presynaptic active zone membrane [GO:0048787]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076]	ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; inward rectifier potassium channel activity [GO:0005242]; sulfonylurea receptor binding [GO:0017098]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]	glutamatergic synapse [GO:0098978]; inward rectifying potassium channel [GO:0008282]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; presynaptic active zone membrane [GO:0048787]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076]; ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; inward rectifier potassium channel activity [GO:0005242]; sulfonylurea receptor binding [GO:0017098]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; atrioventricular node cell differentiation [GO:0060922]; calcium ion transmembrane transport [GO:0070588]; CAMKK-AMPK signaling cascade [GO:0061762]; coronary vasculature development [GO:0060976]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; establishment of cell polarity [GO:0030010]; fat cell differentiation [GO:0045444]; fatty acid transport [GO:0015908]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; glutamate secretion, neurotransmission [GO:0061535]; heart morphogenesis [GO:0003007]; inorganic cation transmembrane transport [GO:0098662]; kidney development [GO:0001822]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; microglial cell activation [GO:0001774]; neuromuscular process [GO:0050905]; NLRP3 inflammasome complex assembly [GO:0044546]; p38MAPK cascade [GO:0038066]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein secretion [GO:0009306]; reactive gliosis [GO:0150103]; regulation of blood pressure [GO:0008217]; regulation of heart rate [GO:0002027]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to ATP [GO:0033198]; response to cytokine [GO:0034097]; response to endoplasmic reticulum stress [GO:0034976]; response to exogenous dsRNA [GO:0043330]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to resveratrol [GO:1904638]; response to xenobiotic stimulus [GO:0009410]; synaptic assembly at neuromuscular junction [GO:0051124]; transmission of nerve impulse [GO:0019226]; transport across blood-brain barrier [GO:0150104]; vasodilation [GO:0042311]; ventricular cardiac muscle tissue development [GO:0003229]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein {ECO:0000305}.
Q15843	reviewed	NEDD8_HUMAN	NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)	NEDD8	Homo sapiens (Human)	81	FUNCTION: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed:9694792, PubMed:10318914, PubMed:10597293, PubMed:11953428, PubMed:15242646, PubMed:14690597). Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (PubMed:9694792, PubMed:10318914, PubMed:10597293, PubMed:11953428, PubMed:20688984). Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity (PubMed:15242646). Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M (PubMed:14690597). {ECO:0000269|PubMed:10318914, ECO:0000269|PubMed:10597293, ECO:0000269|PubMed:11953428, ECO:0000269|PubMed:14690597, ECO:0000269|PubMed:15242646, ECO:0000269|PubMed:20688984, ECO:0000269|PubMed:9694792}.		anatomical structure morphogenesis [GO:0009653]; modification-dependent protein catabolic process [GO:0019941]; protein localization [GO:0008104]; protein modification process [GO:0036211]; protein neddylation [GO:0045116]; proteolysis [GO:0006508]; regulation of proteolysis [GO:0030162]; regulation of transcription by RNA polymerase II [GO:0006357]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein tag activity [GO:0031386]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein tag activity [GO:0031386]; ubiquitin protein ligase binding [GO:0031625]; anatomical structure morphogenesis [GO:0009653]; modification-dependent protein catabolic process [GO:0019941]; protein localization [GO:0008104]; protein modification process [GO:0036211]; protein neddylation [GO:0045116]; proteolysis [GO:0006508]; regulation of proteolysis [GO:0030162]; regulation of transcription by RNA polymerase II [GO:0006357]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9353319}. Note=Mainly nuclear. {ECO:0000269|PubMed:9353319}.
Q15848	reviewed	ADIPO_HUMAN	Adiponectin (30 kDa adipocyte complement-related protein) (Adipocyte complement-related 30 kDa protein) (ACRP30) (Adipocyte, C1q and collagen domain-containing protein) (Adipose most abundant gene transcript 1 protein) (apM-1) (Gelatin-binding protein)	ADIPOQ ACDC ACRP30 APM1 GBP28	Homo sapiens (Human)	244	FUNCTION: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. {ECO:0000269|PubMed:11479627}.	MISCELLANEOUS: Variants Arg-84 and Ser-90 show impaired formation of HMW complexes whereas variants Cys-112 and Thr-164 show impaired secretion of adiponectin in any form.; MISCELLANEOUS: HMW-complex blood contents are higher in females than in males, are increased in males by castration and decreased again upon subsequent testosterone treatment, which blocks HMW-complex secretion (By similarity). In type 2 diabetic patients, both the ratios of HMW to total adiponectin and the degree of adiponectin glycosylation are significantly decreased as compared with healthy controls. {ECO:0000250}.	brown fat cell differentiation [GO:0050873]; cellular response to cAMP [GO:0071320]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to insulin stimulus [GO:0032869]; cellular response to xenobiotic stimulus [GO:0071466]; circadian rhythm [GO:0007623]; detection of oxidative stress [GO:0070994]; fatty acid beta-oxidation [GO:0006635]; fatty acid oxidation [GO:0019395]; gene expression [GO:0010467]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; low-density lipoprotein particle clearance [GO:0034383]; negative regulation of blood pressure [GO:0045776]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell migration [GO:0030336]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of hormone secretion [GO:0046888]; negative regulation of inflammatory response [GO:0050728]; negative regulation of intracellular protein transport [GO:0090317]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of metanephric mesenchymal cell migration [GO:2000590]; negative regulation of phagocytosis [GO:0050765]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000584]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of receptor binding [GO:1900121]; negative regulation of synaptic transmission [GO:0050805]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen (starch) synthase activity [GO:2000467]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lipid transporter activity [GO:0110113]; positive regulation of metanephric podocyte development [GO:2000478]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of myeloid cell apoptotic process [GO:0033034]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of renal albumin absorption [GO:2000534]; positive regulation of signal transduction [GO:0009967]; protein localization to plasma membrane [GO:0072659]; regulation of glucose metabolic process [GO:0010906]; response to activity [GO:0014823]; response to bacterium [GO:0009617]; response to ethanol [GO:0045471]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to linoleic acid [GO:0070543]; response to nutrient [GO:0007584]; response to sucrose [GO:0009744]; response to tumor necrosis factor [GO:0034612]	cell surface [GO:0009986]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; hormone activity [GO:0005179]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activator activity [GO:0043539]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; hormone activity [GO:0005179]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activator activity [GO:0043539]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]; brown fat cell differentiation [GO:0050873]; cellular response to cAMP [GO:0071320]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to insulin stimulus [GO:0032869]; cellular response to xenobiotic stimulus [GO:0071466]; circadian rhythm [GO:0007623]; detection of oxidative stress [GO:0070994]; fatty acid beta-oxidation [GO:0006635]; fatty acid oxidation [GO:0019395]; gene expression [GO:0010467]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; low-density lipoprotein particle clearance [GO:0034383]; negative regulation of blood pressure [GO:0045776]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell migration [GO:0030336]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of hormone secretion [GO:0046888]; negative regulation of inflammatory response [GO:0050728]; negative regulation of intracellular protein transport [GO:0090317]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of metanephric mesenchymal cell migration [GO:2000590]; negative regulation of phagocytosis [GO:0050765]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000584]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of receptor binding [GO:1900121]; negative regulation of synaptic transmission [GO:0050805]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen (starch) synthase activity [GO:2000467]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lipid transporter activity [GO:0110113]; positive regulation of metanephric podocyte development [GO:2000478]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of myeloid cell apoptotic process [GO:0033034]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of renal albumin absorption [GO:2000534]; positive regulation of signal transduction [GO:0009967]; protein localization to plasma membrane [GO:0072659]; regulation of glucose metabolic process [GO:0010906]; response to activity [GO:0014823]; response to bacterium [GO:0009617]; response to ethanol [GO:0045471]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to linoleic acid [GO:0070543]; response to nutrient [GO:0007584]; response to sucrose [GO:0009744]; response to tumor necrosis factor [GO:0034612]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8947845}.
Q15849	reviewed	UT2_HUMAN	Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney)	SLC14A2 HUT2 UT2	Homo sapiens (Human)	920	FUNCTION: [Isoform 1]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:11502588, ECO:0000269|PubMed:17702749}.; FUNCTION: [Isoform 2]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:8647271, ECO:0000269|PubMed:8997401}.		transmembrane transport [GO:0055085]; urea transmembrane transport [GO:0071918]; urea transport [GO:0015840]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cell adhesion molecule binding [GO:0050839]; urea transmembrane transporter activity [GO:0015204]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; urea transmembrane transporter activity [GO:0015204]; transmembrane transport [GO:0055085]; urea transmembrane transport [GO:0071918]; urea transport [GO:0015840]	SUBCELLULAR LOCATION: [Isoform 1]: Apical cell membrane {ECO:0000269|PubMed:17702749}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:17702749}; Multi-pass membrane protein {ECO:0000255}.
Q15853	reviewed	USF2_HUMAN	Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2)	USF2 BHLHB12	Homo sapiens (Human)	346	FUNCTION: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.	MISCELLANEOUS: [Isoform USF2c]: Can bind as a homodimer to the E-box of the cathepsin B (CTSB) promoter. {ECO:0000305}.	lactation [GO:0007595]; late viral transcription [GO:0019086]; lipid homeostasis [GO:0055088]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter by glucose [GO:0000430]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; lactation [GO:0007595]; late viral transcription [GO:0019086]; lipid homeostasis [GO:0055088]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter by glucose [GO:0000430]	SUBCELLULAR LOCATION: Nucleus.
Q15858	reviewed	SCN9A_HUMAN	Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7)	SCN9A NENA	Homo sapiens (Human)	1988	FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784). {ECO:0000269|PubMed:15178348, ECO:0000269|PubMed:15385606, ECO:0000269|PubMed:16988069, ECO:0000269|PubMed:17145499, ECO:0000269|PubMed:17167479, ECO:0000269|PubMed:19369487, ECO:0000269|PubMed:24311784, ECO:0000269|PubMed:25240195, ECO:0000269|PubMed:26680203, ECO:0000269|PubMed:7720699}.		behavioral response to pain [GO:0048266]; calcium ion import across plasma membrane [GO:0098703]; circadian rhythm [GO:0007623]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; inflammatory response [GO:0006954]; post-embryonic development [GO:0009791]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to toxic substance [GO:0009636]; sensory perception of pain [GO:0019233]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	axon [GO:0030424]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]	high voltage-gated calcium channel activity [GO:0008331]; voltage-gated sodium channel activity [GO:0005248]	axon [GO:0030424]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated sodium channel activity [GO:0005248]; behavioral response to pain [GO:0048266]; calcium ion import across plasma membrane [GO:0098703]; circadian rhythm [GO:0007623]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; inflammatory response [GO:0006954]; post-embryonic development [GO:0009791]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to toxic substance [GO:0009636]; sensory perception of pain [GO:0019233]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15385606, ECO:0000269|PubMed:17167479, ECO:0000269|PubMed:19369487, ECO:0000269|PubMed:24311784, ECO:0000269|PubMed:25240195, ECO:0000269|PubMed:26680203, ECO:0000269|PubMed:7720699}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Cell projection, neuron projection {ECO:0000250|UniProtKB:O08562}. Note=In neurite terminals. {ECO:0000250|UniProtKB:O08562}.
Q15878	reviewed	CAC1E_HUMAN	Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3)	CACNA1E CACH6 CACNL1A6	Homo sapiens (Human)	2313	FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. {ECO:0000269|PubMed:30343943}.		calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268]; regulation of monoatomic ion transmembrane transport [GO:0034765]	neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]	calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic cation channel activity [GO:0022843]	neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]; calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic cation channel activity [GO:0022843]; calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q15884	reviewed	EREP1_HUMAN	Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin)	ENTREP1 C9orf61 FAM189A2 X123	Homo sapiens (Human)	450	FUNCTION: Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway. {ECO:0000269|PubMed:34927784}.		CXCL12-activated CXCR4 signaling pathway [GO:0038160]; negative adaptation of signaling pathway [GO:0022401]; receptor internalization [GO:0031623]	early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	ubiquitin ligase activator activity [GO:1990757]	early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; ubiquitin ligase activator activity [GO:1990757]; CXCL12-activated CXCR4 signaling pathway [GO:0038160]; negative adaptation of signaling pathway [GO:0022401]; receptor internalization [GO:0031623]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:34927784}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:34927784}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:34927784}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:34927784}; Single-pass type I membrane protein {ECO:0000255}. Note=Enriched in endosomes compared to the cell membrane. {ECO:0000269|PubMed:34927784}.
Q15904	reviewed	VAS1_HUMAN	V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1)	ATP6AP1 ATP6IP1 ATP6S1 VATPS1 XAP3	Homo sapiens (Human)	470	FUNCTION: Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles (PubMed:33065002). Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity (PubMed:27231034). Involved in membrane trafficking and Ca(2+)-dependent membrane fusion (PubMed:27231034). May play a role in the assembly of the V-type ATPase complex (Probable). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules (By similarity). {ECO:0000250|UniProtKB:Q9R1Q9, ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:27231034, ECO:0000305|PubMed:33065002}.		cellular response to increased oxygen levels [GO:0036295]; endosomal lumen acidification [GO:0048388]; endosome to plasma membrane protein transport [GO:0099638]; Golgi lumen acidification [GO:0061795]; intracellular iron ion homeostasis [GO:0006879]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; osteoclast development [GO:0036035]; proton transmembrane transport [GO:1902600]; regulation of cellular pH [GO:0030641]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	clathrin-coated vesicle membrane [GO:0030665]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]	ATPase activator activity [GO:0001671]; small GTPase binding [GO:0031267]	clathrin-coated vesicle membrane [GO:0030665]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]; ATPase activator activity [GO:0001671]; small GTPase binding [GO:0031267]; cellular response to increased oxygen levels [GO:0036295]; endosomal lumen acidification [GO:0048388]; endosome to plasma membrane protein transport [GO:0099638]; Golgi lumen acidification [GO:0061795]; intracellular iron ion homeostasis [GO:0006879]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; osteoclast development [GO:0036035]; proton transmembrane transport [GO:1902600]; regulation of cellular pH [GO:0030641]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27231034}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:27231034}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O54715}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:O54715}; Single-pass type I membrane protein {ECO:0000305}. Note=Not detected in trans-Golgi network. {ECO:0000269|PubMed:27231034}.
Q15906	reviewed	VPS72_HUMAN	Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1)	VPS72 TCFL1 YL1	Homo sapiens (Human)	364	FUNCTION: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. {ECO:0000269|PubMed:26974126}.		chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; somatic stem cell population maintenance [GO:0035019]; transcription initiation-coupled chromatin remodeling [GO:0045815]	NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP-dependent H2AZ histone chaperone activity [GO:0140849]; DNA binding [GO:0003677]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]	NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; DNA binding [GO:0003677]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; somatic stem cell population maintenance [GO:0035019]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:26974126}.
Q15907	reviewed	RB11B_HUMAN	Ras-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3)	RAB11B YPT3	Homo sapiens (Human)	218	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (Probable). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (Probable). {ECO:0000269|PubMed:14627637, ECO:0000269|PubMed:19029296, ECO:0000269|PubMed:19244346, ECO:0000269|PubMed:20717956, ECO:0000269|PubMed:21248079, ECO:0000269|PubMed:22129970, ECO:0000305|PubMed:25673879, ECO:0000305|PubMed:31204173}.		amyloid-beta clearance by transcytosis [GO:0150093]; cellular response to acidic pH [GO:0071468]; constitutive secretory pathway [GO:0045054]; endocytic recycling [GO:0032456]; establishment of protein localization to membrane [GO:0090150]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; melanosome transport [GO:0032402]; receptor recycling [GO:0001881]; regulated exocytosis [GO:0045055]; regulation of endocytic recycling [GO:2001135]; regulation of monoatomic anion transport [GO:0044070]; regulation of protein localization to cell surface [GO:2000008]; transferrin transport [GO:0033572]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	cadherin binding [GO:0045296]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; cadherin binding [GO:0045296]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; amyloid-beta clearance by transcytosis [GO:0150093]; cellular response to acidic pH [GO:0071468]; constitutive secretory pathway [GO:0045054]; endocytic recycling [GO:0032456]; establishment of protein localization to membrane [GO:0090150]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; melanosome transport [GO:0032402]; receptor recycling [GO:0001881]; regulated exocytosis [GO:0045055]; regulation of endocytic recycling [GO:2001135]; regulation of monoatomic anion transport [GO:0044070]; regulation of protein localization to cell surface [GO:2000008]; transferrin transport [GO:0033572]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:P46638}; Lipid-anchor {ECO:0000250|UniProtKB:P46638}; Cytoplasmic side {ECO:0000250|UniProtKB:P46638}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O35509}; Lipid-anchor {ECO:0000250|UniProtKB:O35509}; Cytoplasmic side {ECO:0000250|UniProtKB:O35509}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305|PubMed:21255211}; Lipid-anchor {ECO:0000305|PubMed:21255211}; Cytoplasmic side {ECO:0000305|PubMed:21255211}. Note=Recruited to phagosomes containing S.aureus. {ECO:0000305|PubMed:21255211}.
Q15910	reviewed	EZH2_HUMAN	Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)	EZH2 KMT6	Homo sapiens (Human)	746	FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:30923826}.		B cell differentiation [GO:0030183]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to trichostatin A [GO:0035984]; cerebellar cortex development [GO:0021695]; chromatin organization [GO:0006325]; DNA methylation [GO:0006306]; facultative heterochromatin formation [GO:0140718]; G1 to G0 transition [GO:0070314]; G1/S transition of mitotic cell cycle [GO:0000082]; hepatocyte homeostasis [GO:0036333]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; keratinocyte differentiation [GO:0030216]; liver regeneration [GO:0097421]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of striated muscle cell differentiation [GO:0051154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; protein localization to chromatin [GO:0071168]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of gliogenesis [GO:0014013]; regulation of kidney development [GO:0090183]; response to estradiol [GO:0032355]; response to tetrachloromethane [GO:1904772]; rhythmic process [GO:0048511]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; stem cell differentiation [GO:0048863]; subtelomeric heterochromatin formation [GO:0031509]; synaptic transmission, GABAergic [GO:0051932]	chromatin [GO:0000785]; chromatin silencing complex [GO:0005677]; chromosome, telomeric region [GO:0000781]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; pronucleus [GO:0045120]; synapse [GO:0045202]	chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; histone H3 methyltransferase activity [GO:0140938]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K27 trimethyltransferase activity [GO:0140951]; histone methyltransferase activity [GO:0042054]; lncRNA binding [GO:0106222]; primary miRNA binding [GO:0070878]; promoter-specific chromatin binding [GO:1990841]; protein-lysine N-methyltransferase activity [GO:0016279]; ribonucleoprotein complex binding [GO:0043021]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]	chromatin [GO:0000785]; chromatin silencing complex [GO:0005677]; chromosome, telomeric region [GO:0000781]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; pronucleus [GO:0045120]; synapse [GO:0045202]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; histone H3 methyltransferase activity [GO:0140938]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K27 trimethyltransferase activity [GO:0140951]; histone methyltransferase activity [GO:0042054]; lncRNA binding [GO:0106222]; primary miRNA binding [GO:0070878]; promoter-specific chromatin binding [GO:1990841]; protein-lysine N-methyltransferase activity [GO:0016279]; ribonucleoprotein complex binding [GO:0043021]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; B cell differentiation [GO:0030183]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to trichostatin A [GO:0035984]; cerebellar cortex development [GO:0021695]; chromatin organization [GO:0006325]; DNA methylation [GO:0006306]; facultative heterochromatin formation [GO:0140718]; G1 to G0 transition [GO:0070314]; G1/S transition of mitotic cell cycle [GO:0000082]; hepatocyte homeostasis [GO:0036333]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; keratinocyte differentiation [GO:0030216]; liver regeneration [GO:0097421]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of striated muscle cell differentiation [GO:0051154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; protein localization to chromatin [GO:0071168]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of gliogenesis [GO:0014013]; regulation of kidney development [GO:0090183]; response to estradiol [GO:0032355]; response to tetrachloromethane [GO:1904772]; rhythmic process [GO:0048511]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; stem cell differentiation [GO:0048863]; subtelomeric heterochromatin formation [GO:0031509]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12101246, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:9584199}. Note=Localizes to the inactive X chromosome in trophoblast stem cells. {ECO:0000250|UniProtKB:Q61188}.
Q15911	reviewed	ZFHX3_HUMAN	Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)	ZFHX3 ATBF1 C16orf47	Homo sapiens (Human)	3703	FUNCTION: Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}.		circadian regulation of gene expression [GO:0032922]; muscle organ development [GO:0007517]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of locomotor rhythm [GO:1904059]; regulation of neuron differentiation [GO:0045664]; regulation of transcription by RNA polymerase II [GO:0006357]; response to transforming growth factor beta [GO:0071559]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; circadian regulation of gene expression [GO:0032922]; muscle organ development [GO:0007517]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of locomotor rhythm [GO:1904059]; regulation of neuron differentiation [GO:0045664]; regulation of transcription by RNA polymerase II [GO:0006357]; response to transforming growth factor beta [GO:0071559]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:24651376}. Cytoplasm {ECO:0000269|PubMed:20599712}. Note=Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. Expressed in nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body. {ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:24651376}.
Q15915	reviewed	ZIC1_HUMAN	Zinc finger protein ZIC 1 (Zinc finger protein 201) (Zinc finger protein of the cerebellum 1)	ZIC1 ZIC ZNF201	Homo sapiens (Human)	447	FUNCTION: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). {ECO:0000250|UniProtKB:P46684}.		adult walking behavior [GO:0007628]; brain development [GO:0007420]; cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; gene expression [GO:0010467]; hippocampus development [GO:0021766]; inner ear morphogenesis [GO:0042472]; maintenance of cell number [GO:0098727]; olfactory bulb development [GO:0021772]; pattern specification process [GO:0007389]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord development [GO:0021510]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; adult walking behavior [GO:0007628]; brain development [GO:0007420]; cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; gene expression [GO:0010467]; hippocampus development [GO:0021766]; inner ear morphogenesis [GO:0042472]; maintenance of cell number [GO:0098727]; olfactory bulb development [GO:0021772]; pattern specification process [GO:0007389]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord development [GO:0021510]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. {ECO:0000250}.
Q15916	reviewed	ZBTB6_HUMAN	Zinc finger and BTB domain-containing protein 6 (Zinc finger protein 482) (Zinc finger protein with interaction domain)	ZBTB6 ZID ZNF482	Homo sapiens (Human)	424	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7958847}.
Q15928	reviewed	ZN141_HUMAN	Zinc finger protein 141	ZNF141 D4S90	Homo sapiens (Human)	474	FUNCTION: May be involved in transcriptional regulation as a repressor. Plays a role in limb development. {ECO:0000269|PubMed:23160277}.		anatomical structure morphogenesis [GO:0009653]; limb morphogenesis [GO:0035108]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; limb morphogenesis [GO:0035108]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q15942	reviewed	ZYX_HUMAN	Zyxin (Zyxin-2)	ZYX	Homo sapiens (Human)	572	FUNCTION: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.		cell-cell signaling [GO:0007267]; cell-matrix adhesion [GO:0007160]; cellular response to type II interferon [GO:0071346]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; cell-cell signaling [GO:0007267]; cell-matrix adhesion [GO:0007160]; cellular response to type II interferon [GO:0071346]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.
Q15973	reviewed	ZN124_HUMAN	Zinc finger protein 124 (Zinc finger protein HZF-16)	ZNF124	Homo sapiens (Human)	351	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q16082	reviewed	HSPB2_HUMAN	Heat shock protein beta-2 (HspB2) (DMPK-binding protein) (MKBP)	HSPB2	Homo sapiens (Human)	182	FUNCTION: May regulate the kinase DMPK. {ECO:0000269|PubMed:9490724}.		negative regulation of apoptotic process [GO:0043066]; protein refolding [GO:0042026]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; somatic muscle development [GO:0007525]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	enzyme activator activity [GO:0008047]; structural constituent of eye lens [GO:0005212]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; enzyme activator activity [GO:0008047]; structural constituent of eye lens [GO:0005212]; unfolded protein binding [GO:0051082]; negative regulation of apoptotic process [GO:0043066]; protein refolding [GO:0042026]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; somatic muscle development [GO:0007525]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus {ECO:0000269|PubMed:19464326}. Note=Localizes to nuclear foci.
Q16099	reviewed	GRIK4_HUMAN	Glutamate receptor ionotropic, kainate 4 (GluK4) (Excitatory amino acid receptor 1) (EAA1) (Glutamate receptor KA-1) (KA1)	GRIK4 GRIK	Homo sapiens (Human)	956	FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.		chemical synaptic transmission [GO:0007268]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]	hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]	kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; chemical synaptic transmission [GO:0007268]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Q16134	reviewed	ETFD_HUMAN	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase)	ETFDH	Homo sapiens (Human)	617	FUNCTION: Accepts electrons from ETF and reduces ubiquinone. {ECO:0000269|PubMed:12049629}.		electron transport chain [GO:0022900]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904]; response to oxidative stress [GO:0006979]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]	4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; electron-transferring-flavoprotein dehydrogenase activity [GO:0004174]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; quinone binding [GO:0048038]; ubiquinone binding [GO:0048039]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; electron-transferring-flavoprotein dehydrogenase activity [GO:0004174]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; quinone binding [GO:0048038]; ubiquinone binding [GO:0048039]; electron transport chain [GO:0022900]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion inner membrane.
Q16143	reviewed	SYUB_HUMAN	Beta-synuclein	SNCB	Homo sapiens (Human)	134	FUNCTION: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.		chemical synaptic transmission [GO:0007268]; dopamine metabolic process [GO:0042417]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488]	axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; neuronal cell body [GO:0043025]	calcium ion binding [GO:0005509]; cuprous ion binding [GO:1903136]; phospholipase inhibitor activity [GO:0004859]; transition metal ion binding [GO:0046914]	axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; neuronal cell body [GO:0043025]; calcium ion binding [GO:0005509]; cuprous ion binding [GO:1903136]; phospholipase inhibitor activity [GO:0004859]; transition metal ion binding [GO:0046914]; chemical synaptic transmission [GO:0007268]; dopamine metabolic process [GO:0042417]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cytoplasm.
Q16181	reviewed	SEPT7_HUMAN	Septin-7 (CDC10 protein homolog)	SEPTIN7 CDC10 SEPT7	Homo sapiens (Human)	437	FUNCTION: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18460473, ECO:0000305|PubMed:25588830}.	MISCELLANEOUS: Coordinated expression with SEPTIN2 and SEPTIN6.	cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; positive regulation of non-motile cilium assembly [GO:1902857]; regulation of embryonic cell shape [GO:0016476]; spermatogenesis [GO:0007283]	axoneme [GO:0005930]; cell division site [GO:0032153]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; stress fiber [GO:0001725]	cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198]	axoneme [GO:0005930]; cell division site [GO:0032153]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; stress fiber [GO:0001725]; cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198]; cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; positive regulation of non-motile cilium assembly [GO:1902857]; regulation of embryonic cell shape [GO:0016476]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18460473}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:18460473}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18460473}. Cleavage furrow {ECO:0000269|PubMed:18460473}. Midbody {ECO:0000269|PubMed:18460473}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:25588830}. Note=Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase. Associated with actin stress fibers (By similarity). Found in the sperm annulus (PubMed:25588830). {ECO:0000250, ECO:0000269|PubMed:25588830}.
Q16186	reviewed	ADRM1_HUMAN	Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)	ADRM1 GP110	Homo sapiens (Human)	407	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497817). Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). {ECO:0000269|PubMed:16815440, ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:16990800, ECO:0000269|PubMed:17139257, ECO:0000269|PubMed:18497817, ECO:0000269|PubMed:24752541, ECO:0000269|PubMed:25702870, ECO:0000269|PubMed:25702872}.		proteasome assembly [GO:0043248]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; transcription elongation by RNA polymerase II [GO:0006368]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]	endopeptidase activator activity [GO:0061133]; molecular function inhibitor activity [GO:0140678]; protease binding [GO:0002020]; proteasome binding [GO:0070628]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; endopeptidase activator activity [GO:0061133]; molecular function inhibitor activity [GO:0140678]; protease binding [GO:0002020]; proteasome binding [GO:0070628]; proteasome assembly [GO:0043248]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16990800}. Nucleus {ECO:0000269|PubMed:16990800}.
Q16204	reviewed	CCDC6_HUMAN	Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4)	CCDC6 D10S170 TST1	Homo sapiens (Human)	474				cytoskeleton [GO:0005856]; cytosol [GO:0005829]	identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; structural constituent of cytoskeleton [GO:0005200]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; structural constituent of cytoskeleton [GO:0005200]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000305}. Note=May be a cytoskeletal protein.
Q16206	reviewed	ENOX2_HUMAN	Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)]	ENOX2 COVA1	Homo sapiens (Human)	610	FUNCTION: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269|PubMed:12356293, ECO:0000269|PubMed:9932650}.	MISCELLANEOUS: Has several properties associated with prions including resistance to proteases, resistance to cyanogen bromide digestion, and the ability to form amyloid filaments resembling those of spongiform encephalopathies.	electron transport chain [GO:0022900]; ultradian rhythm [GO:0007624]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	oxidoreductase activity [GO:0016491]; RNA binding [GO:0003723]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; oxidoreductase activity [GO:0016491]; RNA binding [GO:0003723]; electron transport chain [GO:0022900]; ultradian rhythm [GO:0007624]	SUBCELLULAR LOCATION: Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.
Q16222	reviewed	UAP1_HUMAN	UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Sperm-associated antigen 2) [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC 2.7.7.83) (AGX-1); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (AGX-2)]	UAP1 SPAG2	Homo sapiens (Human)	522	FUNCTION: Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.		UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; UDP-N-acetylgalactosamine diphosphorylase activity [GO:0052630]; UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; UDP-N-acetylgalactosamine diphosphorylase activity [GO:0052630]; UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	SUBCELLULAR LOCATION: Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail.
Q16236	reviewed	NF2L2_HUMAN	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)	NFE2L2 NRF2	Homo sapiens (Human)	605	FUNCTION: Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}.		aflatoxin catabolic process [GO:0046223]; cell redox homeostasis [GO:0045454]; cellular response to angiotensin [GO:1904385]; cellular response to copper ion [GO:0071280]; cellular response to fluid shear stress [GO:0071498]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to oxidative stress [GO:0034599]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; endoplasmic reticulum unfolded protein response [GO:0030968]; inflammatory response [GO:0006954]; integrated stress response signaling [GO:0140467]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of glutathione biosynthetic process [GO:1903788]; positive regulation of neuron projection development [GO:0010976]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of embryonic development [GO:0045995]; regulation of innate immune response [GO:0045088]; regulation of removal of superoxide radicals [GO:2000121]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ischemia [GO:0002931]; response to oxidative stress [GO:0006979]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; ubiquitin protein ligase binding [GO:0031625]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; ubiquitin protein ligase binding [GO:0031625]; aflatoxin catabolic process [GO:0046223]; cell redox homeostasis [GO:0045454]; cellular response to angiotensin [GO:1904385]; cellular response to copper ion [GO:0071280]; cellular response to fluid shear stress [GO:0071498]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to oxidative stress [GO:0034599]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; endoplasmic reticulum unfolded protein response [GO:0030968]; inflammatory response [GO:0006954]; integrated stress response signaling [GO:0140467]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of glutathione biosynthetic process [GO:1903788]; positive regulation of neuron projection development [GO:0010976]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of embryonic development [GO:0045995]; regulation of innate immune response [GO:0045088]; regulation of removal of superoxide radicals [GO:2000121]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ischemia [GO:0002931]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:21196497}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:21196497, ECO:0000269|PubMed:29983246}. Note=Cytosolic under unstressed conditions: ubiquitinated and degraded by the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:15601839, PubMed:21196497). Translocates into the nucleus upon induction by electrophilic agents that inactivate the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:21196497). {ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:21196497}.
Q16254	reviewed	E2F4_HUMAN	Transcription factor E2F4 (E2F-4)	E2F4	Homo sapiens (Human)	413	FUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}.		animal organ morphogenesis [GO:0009887]; blood circulation [GO:0008015]; cell volume homeostasis [GO:0006884]; centriole assembly [GO:0098534]; epithelial cell development [GO:0002064]; motile cilium assembly [GO:0044458]; multi-ciliated epithelial cell differentiation [GO:1903251]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ morphogenesis [GO:0009887]; blood circulation [GO:0008015]; cell volume homeostasis [GO:0006884]; centriole assembly [GO:0098534]; epithelial cell development [GO:0002064]; motile cilium assembly [GO:0044458]; multi-ciliated epithelial cell differentiation [GO:1903251]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	SUBCELLULAR LOCATION: Nucleus.
Q16270	reviewed	IBP7_HUMAN	Insulin-like growth factor-binding protein 7 (IBP-7) (IGF-binding protein 7) (IGFBP-7) (IGFBP-rP1) (MAC25 protein) (PGI2-stimulating factor) (Prostacyclin-stimulating factor) (Tumor-derived adhesion factor) (TAF)	IGFBP7 MAC25 PSF	Homo sapiens (Human)	282	FUNCTION: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. {ECO:0000269|PubMed:8117260, ECO:0000269|PubMed:8939990}.		cell adhesion [GO:0007155]; cellular response to hormone stimulus [GO:0032870]; embryo implantation [GO:0007566]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966]; regulation of steroid biosynthetic process [GO:0050810]; response to cortisol [GO:0051414]; response to retinoic acid [GO:0032526]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	insulin-like growth factor binding [GO:0005520]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binding [GO:0005520]; cell adhesion [GO:0007155]; cellular response to hormone stimulus [GO:0032870]; embryo implantation [GO:0007566]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966]; regulation of steroid biosynthetic process [GO:0050810]; response to cortisol [GO:0051414]; response to retinoic acid [GO:0032526]	SUBCELLULAR LOCATION: Secreted.
Q16280	reviewed	CNGA2_HUMAN	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (Cyclic nucleotide-gated channel alpha-2) (CNG channel alpha-2) (CNG-2) (CNG2)	CNGA2 CNCA CNCA1 CNCG2	Homo sapiens (Human)	664	FUNCTION: Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.		monoatomic cation transmembrane transport [GO:0098655]; response to stimulus [GO:0050896]; sensory perception of smell [GO:0007608]	ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877]	ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877]; monoatomic cation transmembrane transport [GO:0098655]; response to stimulus [GO:0050896]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q16281	reviewed	CNGA3_HUMAN	Cyclic nucleotide-gated cation channel alpha-3 (Cone photoreceptor cGMP-gated channel subunit alpha) (Cyclic nucleotide-gated channel alpha-3) (CNG channel alpha-3) (CNG-3) (CNG3)	CNGA3 CNCG3	Homo sapiens (Human)	694	FUNCTION: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO:0000250, ECO:0000269|PubMed:10888875}.		inorganic cation import across plasma membrane [GO:0098659]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; response to cAMP [GO:0051591]; response to magnesium ion [GO:0032026]; signal transduction [GO:0007165]; visual perception [GO:0007601]	axon initial segment [GO:0043194]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]	cadherin binding [GO:0045296]; cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; myosin binding [GO:0017022]; protein-containing complex binding [GO:0044877]	axon initial segment [GO:0043194]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]; cadherin binding [GO:0045296]; cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; myosin binding [GO:0017022]; protein-containing complex binding [GO:0044877]; inorganic cation import across plasma membrane [GO:0098659]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; response to cAMP [GO:0051591]; response to magnesium ion [GO:0032026]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q16288	reviewed	NTRK3_HUMAN	NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)	NTRK3 TRKC	Homo sapiens (Human)	839	FUNCTION: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269|PubMed:25196463}.		activation of GTPase activity [GO:0090630]; activation of protein kinase B activity [GO:0032148]; cell differentiation [GO:0030154]; cellular response to nerve growth factor stimulus [GO:1990090]; heart development [GO:0007507]; negative regulation of protein phosphorylation [GO:0001933]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein phosphorylation [GO:0001934]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	axon [GO:0030424]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; neurotrophin binding [GO:0043121]; neurotrophin receptor activity [GO:0005030]; p53 binding [GO:0002039]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	axon [GO:0030424]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; neurotrophin binding [GO:0043121]; neurotrophin receptor activity [GO:0005030]; p53 binding [GO:0002039]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; activation of GTPase activity [GO:0090630]; activation of protein kinase B activity [GO:0032148]; cell differentiation [GO:0030154]; cellular response to nerve growth factor stimulus [GO:1990090]; heart development [GO:0007507]; negative regulation of protein phosphorylation [GO:0001933]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein phosphorylation [GO:0001934]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q16322	reviewed	KCA10_HUMAN	Potassium voltage-gated channel subfamily A member 10 (Voltage-gated potassium channel subunit Kv1.8)	KCNA10	Homo sapiens (Human)	511	FUNCTION: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. {ECO:0000269|PubMed:10836990}.		potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; intracellular cyclic nucleotide activated monoatomic cation channel activity [GO:0005221]; voltage-gated potassium channel activity [GO:0005249]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; intracellular cyclic nucleotide activated monoatomic cation channel activity [GO:0005221]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10836990}; Multi-pass membrane protein {ECO:0000269|PubMed:10836990}.
Q16342	reviewed	PDCD2_HUMAN	Programmed cell death protein 2 (Zinc finger MYND domain-containing protein 7) (Zinc finger protein Rp-8)	PDCD2 RP8 ZMYND7	Homo sapiens (Human)	344	FUNCTION: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q16348	reviewed	S15A2_HUMAN	Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)	SLC15A2 PEPT2	Homo sapiens (Human)	729	FUNCTION: Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356, PubMed:18367661, PubMed:16434549). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate (PubMed:7756356). Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (PubMed:16434549). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:20406817). {ECO:0000250|UniProtKB:P46029, ECO:0000250|UniProtKB:Q63424, ECO:0000250|UniProtKB:Q9ES07, ECO:0000269|PubMed:16434549, ECO:0000269|PubMed:18367661, ECO:0000269|PubMed:20406817, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:7756356}.		dipeptide import across plasma membrane [GO:0140206]; dipeptide transport [GO:0042938]; innate immune response [GO:0045087]; monoatomic ion transport [GO:0006811]; peptidoglycan transport [GO:0015835]; protein transport [GO:0015031]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; renal absorption [GO:0070293]; transport across blood-brain barrier [GO:0150104]; tripeptide import across plasma membrane [GO:0140207]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transport [GO:0042908]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; tripeptide transmembrane transporter activity [GO:0042937]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; tripeptide transmembrane transporter activity [GO:0042937]; dipeptide import across plasma membrane [GO:0140206]; dipeptide transport [GO:0042938]; innate immune response [GO:0045087]; monoatomic ion transport [GO:0006811]; peptidoglycan transport [GO:0015835]; protein transport [GO:0015031]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; renal absorption [GO:0070293]; transport across blood-brain barrier [GO:0150104]; tripeptide import across plasma membrane [GO:0140207]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q63424}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:20406817}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:20406817}; Multi-pass membrane protein {ECO:0000255}. Note=Associated with the cell membrane in resting macrophages and enriched in phagocytic cups and phagosomes after particle internalization. {ECO:0000269|PubMed:20406817}.
Q16352	reviewed	AINX_HUMAN	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5)	INA NEF5	Homo sapiens (Human)	499	FUNCTION: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity). {ECO:0000250|UniProtKB:P46660}.		cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; intermediate filament organization [GO:0045109]; neurofilament cytoskeleton organization [GO:0060052]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; substantia nigra development [GO:0021762]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; neurofilament [GO:0005883]; postsynaptic intermediate filament cytoskeleton [GO:0099160]; Schaffer collateral - CA1 synapse [GO:0098685]	structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic intermediate filament cytoskeleton [GO:0099184]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; neurofilament [GO:0005883]; postsynaptic intermediate filament cytoskeleton [GO:0099160]; Schaffer collateral - CA1 synapse [GO:0098685]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic intermediate filament cytoskeleton [GO:0099184]; cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; intermediate filament organization [GO:0045109]; neurofilament cytoskeleton organization [GO:0060052]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; substantia nigra development [GO:0021762]	
Q16363	reviewed	LAMA4_HUMAN	Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha)	LAMA4	Homo sapiens (Human)	1823	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.		cell adhesion [GO:0007155]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	extracellular matrix structural constituent [GO:0005201]; signaling receptor binding [GO:0005102]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular matrix structural constituent [GO:0005201]; signaling receptor binding [GO:0005102]; cell adhesion [GO:0007155]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313}. Note=Major basement membrane component.
Q16384	reviewed	SSX1_HUMAN	Protein SSX1 (Cancer/testis antigen 5.1) (CT5.1) (Synovial sarcoma, X breakpoint 1)	SSX1	Homo sapiens (Human)	188	FUNCTION: Could act as a modulator of transcription (PubMed:7539744). Plays a role in spermatogenesis (PubMed:36796361). {ECO:0000269|PubMed:36796361, ECO:0000269|PubMed:7539744}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; transcription corepressor activity [GO:0003714]; negative regulation of transcription by RNA polymerase II [GO:0000122]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:36796361}.
Q16385	reviewed	SSX2_HUMAN	Protein SSX2 (Cancer/testis antigen 5.2) (CT5.2) (Synovial sarcoma, X breakpoint 2) (Tumor antigen HOM-MEL-40)	SSX2 SSX2A; SSX2B	Homo sapiens (Human)	188	FUNCTION: Could act as a modulator of transcription.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]		nucleus [GO:0005634]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus.
Q16394	reviewed	EXT1_HUMAN	Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 1) (Putative tumor suppressor protein EXT1)	EXT1	Homo sapiens (Human)	746	FUNCTION: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:11518722, ECO:0000269|PubMed:22660413}.		antigen processing and presentation [GO:0019882]; axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; bone resorption [GO:0045453]; canonical Wnt signaling pathway [GO:0060070]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell adhesion mediated by integrin [GO:0033627]; cell fate commitment [GO:0045165]; cellular response to virus [GO:0098586]; chondrocyte hypertrophy [GO:0003415]; chondrocyte proliferation [GO:0035988]; chondroitin sulfate metabolic process [GO:0030204]; collagen fibril organization [GO:0030199]; cranial skeletal system development [GO:1904888]; dendrite self-avoidance [GO:0070593]; dendritic cell migration [GO:0036336]; developmental growth involved in morphogenesis [GO:0060560]; embryonic skeletal joint development [GO:0072498]; endochondral bone growth [GO:0003416]; endochondral ossification [GO:0001958]; endoderm development [GO:0007492]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; fear response [GO:0042596]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fluid transport [GO:0042044]; gastrulation [GO:0007369]; gene expression [GO:0010467]; glandular epithelial cell differentiation [GO:0002067]; glomerular basement membrane development [GO:0032836]; glycosaminoglycan biosynthetic process [GO:0006024]; hair follicle morphogenesis [GO:0031069]; heart contraction [GO:0060047]; heart field specification [GO:0003128]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell homeostasis [GO:0061484]; hematopoietic stem cell migration to bone marrow [GO:0097241]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; hypersensitivity [GO:0002524]; leukocyte tethering or rolling [GO:0050901]; limb joint morphogenesis [GO:0036022]; lymphocyte adhesion to endothelial cell of high endothelial venule [GO:0036339]; lymphocyte migration into lymphoid organs [GO:0097021]; mesenchymal cell differentiation involved in bone development [GO:1901706]; mesoderm development [GO:0007498]; motor behavior [GO:0061744]; multicellular organism growth [GO:0035264]; multicellular organismal-level water homeostasis [GO:0050891]; neural crest cell differentiation [GO:0014033]; olfactory bulb development [GO:0021772]; optic nerve development [GO:0021554]; ossification [GO:0001503]; ossification involved in bone maturation [GO:0043931]; perichondral bone morphogenesis [GO:0061974]; podocyte differentiation [GO:0072112]; polysaccharide biosynthetic process [GO:0000271]; protein catabolic process [GO:0030163]; protein-containing complex assembly [GO:0065003]; regulation of blood pressure [GO:0008217]; response to heparin [GO:0071503]; response to leukemia inhibitory factor [GO:1990823]; response to light intensity [GO:0009642]; sebaceous gland development [GO:0048733]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; smoothened signaling pathway involved in lung development [GO:0060506]; social behavior [GO:0035176]; sodium ion homeostasis [GO:0055078]; stem cell division [GO:0017145]; stomach development [GO:0062094]; sulfation [GO:0051923]; sweat gland development [GO:0060792]; synaptic transmission, glutamatergic [GO:0035249]; tight junction organization [GO:0120193]; TNFSF11-mediated signaling pathway [GO:0071847]; vacuole organization [GO:0007033]; vasodilation [GO:0042311]; vocalization behavior [GO:0071625]; wound healing [GO:0042060]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; synapse [GO:0045202]	acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020]; glycosyltransferase activity [GO:0016757]; heparan sulfate N-acetylglucosaminyltransferase activity [GO:0042328]; metal ion binding [GO:0046872]; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; synapse [GO:0045202]; acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020]; glycosyltransferase activity [GO:0016757]; heparan sulfate N-acetylglucosaminyltransferase activity [GO:0042328]; metal ion binding [GO:0046872]; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; antigen processing and presentation [GO:0019882]; axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; bone resorption [GO:0045453]; canonical Wnt signaling pathway [GO:0060070]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell adhesion mediated by integrin [GO:0033627]; cell fate commitment [GO:0045165]; cellular response to virus [GO:0098586]; chondrocyte hypertrophy [GO:0003415]; chondrocyte proliferation [GO:0035988]; chondroitin sulfate metabolic process [GO:0030204]; collagen fibril organization [GO:0030199]; cranial skeletal system development [GO:1904888]; dendrite self-avoidance [GO:0070593]; dendritic cell migration [GO:0036336]; developmental growth involved in morphogenesis [GO:0060560]; embryonic skeletal joint development [GO:0072498]; endochondral bone growth [GO:0003416]; endochondral ossification [GO:0001958]; endoderm development [GO:0007492]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; fear response [GO:0042596]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fluid transport [GO:0042044]; gastrulation [GO:0007369]; gene expression [GO:0010467]; glandular epithelial cell differentiation [GO:0002067]; glomerular basement membrane development [GO:0032836]; glycosaminoglycan biosynthetic process [GO:0006024]; hair follicle morphogenesis [GO:0031069]; heart contraction [GO:0060047]; heart field specification [GO:0003128]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell homeostasis [GO:0061484]; hematopoietic stem cell migration to bone marrow [GO:0097241]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; hypersensitivity [GO:0002524]; leukocyte tethering or rolling [GO:0050901]; limb joint morphogenesis [GO:0036022]; lymphocyte adhesion to endothelial cell of high endothelial venule [GO:0036339]; lymphocyte migration into lymphoid organs [GO:0097021]; mesenchymal cell differentiation involved in bone development [GO:1901706]; mesoderm development [GO:0007498]; motor behavior [GO:0061744]; multicellular organism growth [GO:0035264]; multicellular organismal-level water homeostasis [GO:0050891]; neural crest cell differentiation [GO:0014033]; olfactory bulb development [GO:0021772]; optic nerve development [GO:0021554]; ossification [GO:0001503]; ossification involved in bone maturation [GO:0043931]; perichondral bone morphogenesis [GO:0061974]; podocyte differentiation [GO:0072112]; polysaccharide biosynthetic process [GO:0000271]; protein catabolic process [GO:0030163]; protein-containing complex assembly [GO:0065003]; regulation of blood pressure [GO:0008217]; response to heparin [GO:0071503]; response to leukemia inhibitory factor [GO:1990823]; response to light intensity [GO:0009642]; sebaceous gland development [GO:0048733]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; smoothened signaling pathway involved in lung development [GO:0060506]; social behavior [GO:0035176]; sodium ion homeostasis [GO:0055078]; stem cell division [GO:0017145]; stomach development [GO:0062094]; sulfation [GO:0051923]; sweat gland development [GO:0060792]; synaptic transmission, glutamatergic [GO:0035249]; tight junction organization [GO:0120193]; TNFSF11-mediated signaling pathway [GO:0071847]; vacuole organization [GO:0007033]; vasodilation [GO:0042311]; vocalization behavior [GO:0071625]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:35137078}; Single-pass type II membrane protein {ECO:0000255}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
Q16401	reviewed	PSMD5_HUMAN	26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B)	PSMD5 KIAA0072	Homo sapiens (Human)	504	FUNCTION: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5. {ECO:0000269|PubMed:19412159, ECO:0000269|PubMed:19490896}.		proteasome regulatory particle assembly [GO:0070682]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle assembly [GO:0070682]	
Q16445	reviewed	GBRA6_HUMAN	Gamma-aminobutyric acid receptor subunit alpha-6 (GABA(A) receptor subunit alpha-6)	GABRA6	Homo sapiens (Human)	453	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.		chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of postsynaptic membrane potential [GO:0060078]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]	cerebellar Golgi cell to granule cell synapse [GO:0099192]; chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	cerebellar Golgi cell to granule cell synapse [GO:0099192]; chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of postsynaptic membrane potential [GO:0060078]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Q16478	reviewed	GRIK5_HUMAN	Glutamate receptor ionotropic, kainate 5 (GluK5) (Excitatory amino acid receptor 2) (EAA2) (Glutamate receptor KA-2) (KA2)	GRIK5 GRIK2	Homo sapiens (Human)	980	FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.		excitatory postsynaptic potential [GO:0060079]; modulation of chemical synaptic transmission [GO:0050804]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; synaptic transmission, glutamatergic [GO:0035249]	endoplasmic reticulum [GO:0005783]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]	kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	endoplasmic reticulum [GO:0005783]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; excitatory postsynaptic potential [GO:0060079]; modulation of chemical synaptic transmission [GO:0050804]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Q16512	reviewed	PKN1_HUMAN	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)	PKN1 PAK1 PKN PRK1 PRKCL1	Homo sapiens (Human)	942	FUNCTION: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}.		B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; epithelial cell migration [GO:0010631]; hyperosmotic response [GO:0006972]; intracellular signal transduction [GO:0035556]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of protein phosphorylation [GO:0001933]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of cell motility [GO:2000145]; regulation of germinal center formation [GO:0002634]; regulation of immunoglobulin production [GO:0002637]; regulation of transcription by RNA polymerase II [GO:0006357]; renal system process [GO:0003014]; signal transduction [GO:0007165]; spleen development [GO:0048536]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; histone H3T11 kinase activity [GO:0035402]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; histone H3T11 kinase activity [GO:0035402]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; epithelial cell migration [GO:0010631]; hyperosmotic response [GO:0006972]; intracellular signal transduction [GO:0035556]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of protein phosphorylation [GO:0001933]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of cell motility [GO:2000145]; regulation of germinal center formation [GO:0002634]; regulation of immunoglobulin production [GO:0002637]; regulation of transcription by RNA polymerase II [GO:0006357]; renal system process [GO:0003014]; signal transduction [GO:0007165]; spleen development [GO:0048536]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:9478917}. Nucleus {ECO:0000269|PubMed:12514133}. Endosome {ECO:0000269|PubMed:9478917}. Cell membrane {ECO:0000250|UniProtKB:Q63433}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63433}. Cleavage furrow {ECO:0000269|PubMed:17332740}. Midbody {ECO:0000269|PubMed:17332740}. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. {ECO:0000250|UniProtKB:Q63433, ECO:0000269|PubMed:17332740}.
Q16513	reviewed	PKN2_HUMAN	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)	PKN2 PRK2 PRKCL2	Homo sapiens (Human)	984	FUNCTION: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}.		apical junction assembly [GO:0043297]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell projection organization [GO:0030030]; epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of cell motility [GO:2000145]; signal transduction [GO:0007165]	apical junction complex [GO:0043296]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium-dependent protein kinase C activity [GO:0004698]; histone deacetylase binding [GO:0042826]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; small GTPase binding [GO:0031267]	apical junction complex [GO:0043296]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium-dependent protein kinase C activity [GO:0004698]; histone deacetylase binding [GO:0042826]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; small GTPase binding [GO:0031267]; apical junction assembly [GO:0043297]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell projection organization [GO:0030030]; epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of cell motility [GO:2000145]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11356191, ECO:0000269|PubMed:17332740}. Nucleus {ECO:0000269|PubMed:11356191}. Membrane {ECO:0000250|UniProtKB:Q8BWW9}. Cell projection, lamellipodium {ECO:0000269|PubMed:11356191}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11356191}. Cleavage furrow {ECO:0000269|PubMed:17332740}. Midbody {ECO:0000269|PubMed:17332740}. Cell junction {ECO:0000269|PubMed:20974804}. Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm. {ECO:0000269|PubMed:11356191, ECO:0000269|PubMed:17332740}.
Q16514	reviewed	TAF12_HUMAN	Transcription initiation factor TFIID subunit 12 (Transcription initiation factor TFIID 20/15 kDa subunits) (TAFII-20/TAFII-15) (TAFII20/TAFII15)	TAF12 TAF15 TAF2J TAFII20	Homo sapiens (Human)	161	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:7729427, PubMed:8598932, PubMed:8663456, PubMed:9674425, PubMed:9885574). {ECO:0000269|PubMed:10373431, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:7729427, ECO:0000269|PubMed:8598932, ECO:0000269|PubMed:8663456, ECO:0000269|PubMed:9674425, ECO:0000269|PubMed:9885574}.		DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]	DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; protein heterodimerization activity [GO:0046982]; TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; protein heterodimerization activity [GO:0046982]; TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]; DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9674425}.
Q16515	reviewed	ASIC2_HUMAN	Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG)	ASIC2 ACCN ACCN1 BNAC1 MDEG	Homo sapiens (Human)	512	FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.	MISCELLANEOUS: Inhibited by anti-inflammatory drugs like salicylic acid (By similarity). Regulated by Zn(2+). {ECO:0000250}.	cellular response to acidic pH [GO:0071468]; cellular response to xenobiotic stimulus [GO:0071466]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; establishment of localization in cell [GO:0051649]; inorganic cation transmembrane transport [GO:0098662]; negative regulation of apoptotic process [GO:0043066]; peripheral nervous system development [GO:0007422]; phototransduction [GO:0007602]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback [GO:0003026]; regulation of vasoconstriction [GO:0019229]; sensory perception of sound [GO:0007605]; sensory perception of sour taste [GO:0050915]; sodium ion transmembrane transport [GO:0035725]; synapse assembly [GO:0007416]	dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	ligand-gated sodium channel activity [GO:0015280]; voltage-gated sodium channel activity [GO:0005248]	dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; ligand-gated sodium channel activity [GO:0015280]; voltage-gated sodium channel activity [GO:0005248]; cellular response to acidic pH [GO:0071468]; cellular response to xenobiotic stimulus [GO:0071466]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; establishment of localization in cell [GO:0051649]; inorganic cation transmembrane transport [GO:0098662]; negative regulation of apoptotic process [GO:0043066]; peripheral nervous system development [GO:0007422]; phototransduction [GO:0007602]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback [GO:0003026]; regulation of vasoconstriction [GO:0019229]; sensory perception of sound [GO:0007605]; sensory perception of sour taste [GO:0050915]; sodium ion transmembrane transport [GO:0035725]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. {ECO:0000250}.
Q16518	reviewed	RPE65_HUMAN	Retinoid isomerohydrolase (EC 3.1.1.64) (All-trans-retinyl-palmitate hydrolase) (Lutein isomerase) (Meso-zeaxanthin isomerase) (EC 5.3.3.22) (Retinal pigment epithelium-specific 65 kDa protein) (Retinol isomerase)	RPE65	Homo sapiens (Human)	533	FUNCTION: Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17848510). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity). {ECO:0000250|UniProtKB:Q28175, ECO:0000269|PubMed:16116091, ECO:0000269|PubMed:17848510, ECO:0000269|PubMed:28874556}.		cellular response to electrical stimulus [GO:0071257]; circadian rhythm [GO:0007623]; detection of light stimulus involved in visual perception [GO:0050908]; insulin receptor signaling pathway [GO:0008286]; neural retina development [GO:0003407]; regulation of gene expression [GO:0010468]; retina homeostasis [GO:0001895]; retina morphogenesis in camera-type eye [GO:0060042]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; visual perception [GO:0007601]; vitamin A metabolic process [GO:0006776]; zeaxanthin biosynthetic process [GO:1901827]	cell body [GO:0044297]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity [GO:0052885]; all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity [GO:0052884]; beta-carotene 15,15'-dioxygenase activity [GO:0003834]; cardiolipin binding [GO:1901612]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; phosphatidylcholine binding [GO:0031210]; phosphatidylserine binding [GO:0001786]; retinol isomerase activity [GO:0050251]	cell body [GO:0044297]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity [GO:0052885]; all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity [GO:0052884]; beta-carotene 15,15'-dioxygenase activity [GO:0003834]; cardiolipin binding [GO:1901612]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; phosphatidylcholine binding [GO:0031210]; phosphatidylserine binding [GO:0001786]; retinol isomerase activity [GO:0050251]; cellular response to electrical stimulus [GO:0071257]; circadian rhythm [GO:0007623]; detection of light stimulus involved in visual perception [GO:0050908]; insulin receptor signaling pathway [GO:0008286]; neural retina development [GO:0003407]; regulation of gene expression [GO:0010468]; retina homeostasis [GO:0001895]; retina morphogenesis in camera-type eye [GO:0060042]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; visual perception [GO:0007601]; vitamin A metabolic process [GO:0006776]; zeaxanthin biosynthetic process [GO:1901827]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A9C3R9}. Cell membrane {ECO:0000269|PubMed:19049981}; Lipid-anchor {ECO:0000269|PubMed:19049981}. Microsome membrane {ECO:0000250|UniProtKB:Q28175}. Note=Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated. Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells. {ECO:0000269|PubMed:19049981, ECO:0000269|PubMed:21493626}.
Q16520	reviewed	BATF_HUMAN	Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) (B-ATF) (SF-HT-activated gene 2 protein) (SFA-2)	BATF	Homo sapiens (Human)	125	FUNCTION: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity). {ECO:0000250}.		defense response to protozoan [GO:0042832]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; hematopoietic stem cell differentiation [GO:0060218]; integrated stress response signaling [GO:0140467]; isotype switching [GO:0045190]; lymphoid progenitor cell differentiation [GO:0002320]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of cytokine production [GO:0001819]; regulation of T-helper 17 cell differentiation [GO:2000319]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 17 cell differentiation [GO:0072539]; T-helper 17 cell lineage commitment [GO:0072540]; T-helper 2 cell differentiation [GO:0045064]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; defense response to protozoan [GO:0042832]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; hematopoietic stem cell differentiation [GO:0060218]; integrated stress response signaling [GO:0140467]; isotype switching [GO:0045190]; lymphoid progenitor cell differentiation [GO:0002320]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of cytokine production [GO:0001819]; regulation of T-helper 17 cell differentiation [GO:2000319]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 17 cell differentiation [GO:0072539]; T-helper 17 cell lineage commitment [GO:0072540]; T-helper 2 cell differentiation [GO:0045064]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. Cytoplasm {ECO:0000250}. Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells. {ECO:0000250}.
Q16526	reviewed	CRY1_HUMAN	Cryptochrome-1	CRY1 PHLL1	Homo sapiens (Human)	586	FUNCTION: Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-BMAL1 independently of PER proteins and is found at CLOCK-BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-BMAL1 induced transcription of ATF4, MTA1, KLF10 and NAMPT (By similarity). May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Inhibits hepatic gluconeogenesis by decreasing nuclear FOXO1 levels that down-regulates gluconeogenic gene expression (By similarity). Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4 (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Plays an essential role in the generation of circadian rhythms in the retina (By similarity). Represses the transcriptional activity of NR1I2 (By similarity). {ECO:0000250|UniProtKB:P97784, ECO:0000269|PubMed:10531061, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:22170608, ECO:0000269|PubMed:23133559, ECO:0000269|PubMed:28388406}.		blue light signaling pathway [GO:0009785]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; lipid storage [GO:0019915]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of glucocorticoid secretion [GO:2000850]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein ubiquitination [GO:0031398]; regulation of circadian rhythm [GO:0042752]; regulation of DNA damage checkpoint [GO:2000001]; response to activity [GO:0014823]; response to glucagon [GO:0033762]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416]; selective autophagy [GO:0061912]; signal transduction in response to DNA damage [GO:0042770]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	blue light photoreceptor activity [GO:0009882]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; E-box binding [GO:0070888]; FAD binding [GO:0071949]; histone deacetylase binding [GO:0042826]; nuclear receptor binding [GO:0016922]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; blue light photoreceptor activity [GO:0009882]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; E-box binding [GO:0070888]; FAD binding [GO:0071949]; histone deacetylase binding [GO:0042826]; nuclear receptor binding [GO:0016922]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; blue light signaling pathway [GO:0009785]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; lipid storage [GO:0019915]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of glucocorticoid secretion [GO:2000850]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein ubiquitination [GO:0031398]; regulation of circadian rhythm [GO:0042752]; regulation of DNA damage checkpoint [GO:2000001]; response to activity [GO:0014823]; response to glucagon [GO:0033762]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416]; selective autophagy [GO:0061912]; signal transduction in response to DNA damage [GO:0042770]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000269|PubMed:22798407, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:28388406}. Note=Translocated to the nucleus through interaction with other clock proteins such as PER2 or BMAL1. {ECO:0000250|UniProtKB:P97784}.
Q16527	reviewed	CSRP2_HUMAN	Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (LIM domain only protein 5) (LMO-5) (Smooth muscle cell LIM protein) (SmLIM)	CSRP2 LMO5 SMLIM	Homo sapiens (Human)	193	FUNCTION: Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.		cell differentiation [GO:0030154]; muscle tissue development [GO:0060537]; sarcomere organization [GO:0045214]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; Z disc [GO:0030018]	actinin binding [GO:0042805]; metal ion binding [GO:0046872]; structural constituent of muscle [GO:0008307]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; Z disc [GO:0030018]; actinin binding [GO:0042805]; metal ion binding [GO:0046872]; structural constituent of muscle [GO:0008307]; cell differentiation [GO:0030154]; muscle tissue development [GO:0060537]; sarcomere organization [GO:0045214]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q16531	reviewed	DDB1_HUMAN	DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)	DDB1 XAP1	Homo sapiens (Human)	1140	FUNCTION: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:15448697, PubMed:14739464, PubMed:16260596, PubMed:16482215, PubMed:17079684, PubMed:16407242, PubMed:16407252, PubMed:16940174). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:25043012, PubMed:25108355, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:28886238). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:25043012, PubMed:25108355, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460). DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16678110, PubMed:17041588, PubMed:16473935, PubMed:18593899). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16678110, PubMed:17041588, PubMed:16473935, PubMed:18593899). DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:17041588). DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) (PubMed:12732143). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). Maternal factor required for proper zygotic genome activation and genome reprogramming (By similarity). {ECO:0000250|UniProtKB:Q3U1J4, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16407242, ECO:0000269|PubMed:16407252, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16482215, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:16940174, ECO:0000269|PubMed:17041588, ECO:0000269|PubMed:17079684, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19966799, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:28886238}.		apoptotic process [GO:0006915]; biological process involved in interaction with symbiont [GO:0051702]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; ectopic germ cell programmed cell death [GO:0035234]; epigenetic programming in the zygotic pronuclei [GO:0044725]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of reproductive process [GO:2000242]; nucleotide-excision repair [GO:0006289]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of viral genome replication [GO:0045070]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; regulation of mitotic cell cycle phase transition [GO:1901990]; rhythmic process [GO:0048511]; spindle assembly involved in female meiosis [GO:0007056]; ubiquitin-dependent protein catabolic process [GO:0006511]; UV-damage excision repair [GO:0070914]; viral release from host cell [GO:0019076]; Wnt signaling pathway [GO:0016055]	chromosome, telomeric region [GO:0000781]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]	cullin family protein binding [GO:0097602]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin ligase complex scaffold activity [GO:0160072]; WD40-repeat domain binding [GO:0071987]	chromosome, telomeric region [GO:0000781]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]; cullin family protein binding [GO:0097602]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin ligase complex scaffold activity [GO:0160072]; WD40-repeat domain binding [GO:0071987]; apoptotic process [GO:0006915]; biological process involved in interaction with symbiont [GO:0051702]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; ectopic germ cell programmed cell death [GO:0035234]; epigenetic programming in the zygotic pronuclei [GO:0044725]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of reproductive process [GO:2000242]; nucleotide-excision repair [GO:0006289]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of viral genome replication [GO:0045070]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; regulation of mitotic cell cycle phase transition [GO:1901990]; rhythmic process [GO:0048511]; spindle assembly involved in female meiosis [GO:0007056]; ubiquitin-dependent protein catabolic process [GO:0006511]; UV-damage excision repair [GO:0070914]; viral release from host cell [GO:0019076]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10777491, ECO:0000269|PubMed:11673459, ECO:0000269|PubMed:18593899}. Nucleus {ECO:0000269|PubMed:10777491, ECO:0000269|PubMed:11673459, ECO:0000269|PubMed:18593899}. Note=Primarily cytoplasmic (PubMed:10777491, PubMed:11673459). Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage (PubMed:10777491, PubMed:11673459). More concentrated in nuclei than in cytoplasm in germinal vesicle (GV) stage oocytes, zygotes and the 2-cell stage, but distributed in the cytoplasm at the MII-stage oocytes (By similarity). {ECO:0000250|UniProtKB:Q3U1J4, ECO:0000269|PubMed:10777491, ECO:0000269|PubMed:11673459}.
Q16533	reviewed	SNPC1_HUMAN	snRNA-activating protein complex subunit 1 (SNAPc subunit 1) (Proximal sequence element-binding transcription factor subunit gamma) (PSE-binding factor subunit gamma) (PTF subunit gamma) (Small nuclear RNA-activating complex polypeptide 1) (snRNA-activating protein complex 43 kDa subunit) (SNAPc 43 kDa subunit)	SNAPC1 SNAP43	Homo sapiens (Human)	368	FUNCTION: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}.		snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; snRNA-activating protein complex [GO:0019185]	RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; sequence-specific DNA binding [GO:0043565]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; snRNA-activating protein complex [GO:0019185]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; sequence-specific DNA binding [GO:0043565]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]	SUBCELLULAR LOCATION: Nucleus.
Q16534	reviewed	HLF_HUMAN	Hepatic leukemia factor	HLF	Homo sapiens (Human)	295			positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; skeletal muscle cell differentiation [GO:0035914]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q16537	reviewed	2A5E_HUMAN	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon)	PPP2R5E	Homo sapiens (Human)	467	FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.		signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm.
Q16539	reviewed	MK14_HUMAN	Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)	MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	Homo sapiens (Human)	360	FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510, PubMed:9792677). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery (PubMed:9687510, PubMed:9792677). On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53 (PubMed:10747897). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3 (PubMed:17003045). MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9 (PubMed:19893488). Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors (PubMed:16932740). Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17 (PubMed:20188673). Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:9430721, PubMed:9858528, PubMed:10330143). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation (PubMed:11333986). Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation (PubMed:20932473). The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression (PubMed:10943842). Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113' (PubMed:15905572). Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:10747897, ECO:0000269|PubMed:10943842, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:16932740, ECO:0000269|PubMed:17003045, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:19893488, ECO:0000269|PubMed:20188673, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9792677, ECO:0000269|PubMed:9858528}.; FUNCTION: (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minutes and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573). {ECO:0000269|PubMed:21586573}.		3'-UTR-mediated mRNA stabilization [GO:0070935]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; bone development [GO:0060348]; cartilage condensation [GO:0001502]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ionizing radiation [GO:0071479]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; chemotaxis [GO:0006935]; chondrocyte differentiation [GO:0002062]; DNA damage checkpoint signaling [GO:0000077]; fatty acid oxidation [GO:0019395]; glucose import [GO:0046323]; glucose metabolic process [GO:0006006]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of hippo signaling [GO:0035331]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; p38MAPK cascade [GO:0038066]; peptidyl-serine phosphorylation [GO:0018105]; placenta development [GO:0001890]; platelet activation [GO:0030168]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cyclase activity [GO:0031281]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of ossification [GO:0030278]; regulation of synaptic membrane adhesion [GO:0099179]; regulation of transcription by RNA polymerase II [GO:0006357]; response to dietary excess [GO:0002021]; response to insulin [GO:0032868]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]; stress-induced premature senescence [GO:0090400]; striated muscle cell differentiation [GO:0051146]; transcription by RNA polymerase II [GO:0006366]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase p38 binding [GO:0048273]; NFAT protein binding [GO:0051525]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase p38 binding [GO:0048273]; NFAT protein binding [GO:0051525]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; bone development [GO:0060348]; cartilage condensation [GO:0001502]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ionizing radiation [GO:0071479]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; chemotaxis [GO:0006935]; chondrocyte differentiation [GO:0002062]; DNA damage checkpoint signaling [GO:0000077]; fatty acid oxidation [GO:0019395]; glucose import [GO:0046323]; glucose metabolic process [GO:0006006]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of hippo signaling [GO:0035331]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; p38MAPK cascade [GO:0038066]; peptidyl-serine phosphorylation [GO:0018105]; placenta development [GO:0001890]; platelet activation [GO:0030168]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cyclase activity [GO:0031281]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of ossification [GO:0030278]; regulation of synaptic membrane adhesion [GO:0099179]; regulation of transcription by RNA polymerase II [GO:0006357]; response to dietary excess [GO:0002021]; response to insulin [GO:0032868]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]; stress-induced premature senescence [GO:0090400]; striated muscle cell differentiation [GO:0051146]; transcription by RNA polymerase II [GO:0006366]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7535770}. Nucleus {ECO:0000269|PubMed:30878395, ECO:0000269|PubMed:7535770}.
Q16540	reviewed	RM23_HUMAN	Large ribosomal subunit protein uL23m (39S ribosomal protein L23, mitochondrial) (L23mt) (MRP-L23) (L23 mitochondrial-related protein) (Ribosomal protein L23-like)	MRPL23 L23MRP RPL23L	Homo sapiens (Human)	153			mitochondrial translation [GO:0032543]; translation [GO:0006412]	fibrillar center [GO:0001650]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	fibrillar center [GO:0001650]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q16543	reviewed	CDC37_HUMAN	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]	CDC37 CDC37A	Homo sapiens (Human)	378	FUNCTION: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}.		positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; post-transcriptional regulation of gene expression [GO:0010608]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; regulation of type II interferon-mediated signaling pathway [GO:0060334]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; HSP90-CDC37 chaperone complex [GO:1990565]; protein folding chaperone complex [GO:0101031]	heat shock protein binding [GO:0031072]; Hsp90 protein binding [GO:0051879]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein-folding chaperone binding [GO:0051087]; scaffold protein binding [GO:0097110]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; HSP90-CDC37 chaperone complex [GO:1990565]; protein folding chaperone complex [GO:0101031]; heat shock protein binding [GO:0031072]; Hsp90 protein binding [GO:0051879]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein-folding chaperone binding [GO:0051087]; scaffold protein binding [GO:0097110]; unfolded protein binding [GO:0051082]; positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; post-transcriptional regulation of gene expression [GO:0010608]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; regulation of type II interferon-mediated signaling pathway [GO:0060334]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9482106}.
Q16548	reviewed	B2LA1_HUMAN	Bcl-2-related protein A1 (Bcl-2-like protein 5) (Bcl2-L-5) (Hemopoietic-specific early response protein) (Protein BFL-1) (Protein GRS)	BCL2A1 BCL2L5 BFL1 GRS HBPA1	Homo sapiens (Human)	175	FUNCTION: Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q07440}.		extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitochondrial fusion [GO:0008053]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; release of cytochrome c from mitochondria [GO:0001836]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]	channel activity [GO:0015267]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; channel activity [GO:0015267]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitochondrial fusion [GO:0008053]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; release of cytochrome c from mitochondria [GO:0001836]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34245648}.
Q16549	reviewed	PCSK7_HUMAN	Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7)	PCSK7 LPC PC7 PC8 SPC7	Homo sapiens (Human)	785	FUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.		peptide hormone processing [GO:0016486]; protein processing [GO:0016485]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Seems to be localized intracellularly to the trans Golgi network. {ECO:0000250}.
Q16552	reviewed	IL17_HUMAN	Interleukin-17A (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8)	IL17A CTLA8 IL17	Homo sapiens (Human)	155	FUNCTION: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:24120361). Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:19825828, PubMed:21350122, PubMed:17911633, PubMed:18684971, PubMed:8676080, PubMed:24120361). Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance (By similarity). Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation (By similarity). Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection (PubMed:21350122). Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis (By similarity). As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release (By similarity). In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms (By similarity). Enhances immunity against West Nile virus by promoting T cell cytotoxicity (By similarity). May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung (By similarity). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). {ECO:0000250|UniProtKB:Q62386, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:8676080}.		adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; cell death [GO:0008219]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; fibroblast activation [GO:0072537]; gene expression [GO:0010467]; granulocyte migration [GO:0097530]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; intestinal epithelial structure maintenance [GO:0060729]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of inflammatory response to wounding [GO:0106015]; Notch signaling pathway [GO:0007219]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-16 production [GO:0032739]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; response to wounding [GO:0009611]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; cell death [GO:0008219]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; fibroblast activation [GO:0072537]; gene expression [GO:0010467]; granulocyte migration [GO:0097530]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; intestinal epithelial structure maintenance [GO:0060729]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of inflammatory response to wounding [GO:0106015]; Notch signaling pathway [GO:0007219]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-16 production [GO:0032739]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17763419, ECO:0000269|PubMed:8676080}.
Q16553	reviewed	LY6E_HUMAN	Lymphocyte antigen 6E (Ly-6E) (Retinoic acid-induced gene E protein) (RIG-E) (Stem cell antigen 2) (SCA-2) (Thymic shared antigen 1) (TSA-1)	LY6E 9804 RIGE SCA2 TSA1	Homo sapiens (Human)	131	FUNCTION: GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482). Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity). {ECO:0000250|UniProtKB:Q64253, ECO:0000269|PubMed:32641482}.; FUNCTION: (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus (PubMed:28130445). In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E (PubMed:28130445, PubMed:29610346). Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape (PubMed:28130445, PubMed:30190477). {ECO:0000269|PubMed:28130445, ECO:0000269|PubMed:29610346, ECO:0000269|PubMed:30190477}.		cell surface receptor signaling pathway [GO:0007166]; negative regulation of viral entry into host cell [GO:0046597]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	acetylcholine receptor inhibitor activity [GO:0030550]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; acetylcholine receptor inhibitor activity [GO:0030550]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of viral entry into host cell [GO:0046597]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q64253}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q64253}.
Q16555	reviewed	DPYL2_HUMAN	Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)	DPYSL2 CRMP2 ULIP2	Homo sapiens (Human)	572	FUNCTION: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}.		cell differentiation [GO:0030154]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; signal transduction [GO:0007165]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	dihydropyrimidinase activity [GO:0004157]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; identical protein binding [GO:0042802]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; dihydropyrimidinase activity [GO:0004157]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; identical protein binding [GO:0042802]; cell differentiation [GO:0030154]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20801876}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20801876}. Membrane {ECO:0000269|PubMed:20801876}. Note=Tightly but non-covalently associated with membranes.
Q16558	reviewed	KCMB1_HUMAN	Calcium-activated potassium channel subunit beta-1 (BK channel subunit beta-1) (BKbeta) (BKbeta1) (Hbeta1) (Calcium-activated potassium channel, subfamily M subunit beta-1) (Calcium-activated potassium channel subunit beta) (Charybdotoxin receptor subunit beta-1) (K(VCA)beta-1) (Maxi K channel subunit beta-1) (Slo-beta-1) (Slo-beta)	KCNMB1	Homo sapiens (Human)	191	FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.		cellular response to bile acid [GO:1903413]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; chemical synaptic transmission [GO:0007268]; detection of calcium ion [GO:0005513]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transport [GO:0006813]; vasodilation [GO:0042311]	plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]	calcium-activated potassium channel activity [GO:0015269]; potassium channel regulator activity [GO:0015459]	plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]; calcium-activated potassium channel activity [GO:0015269]; potassium channel regulator activity [GO:0015459]; cellular response to bile acid [GO:1903413]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; chemical synaptic transmission [GO:0007268]; detection of calcium ion [GO:0005513]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transport [GO:0006813]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q16560	reviewed	U1SBP_HUMAN	U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12 snRNP 35 kDa protein) (U11/U12-35K) (Protein HM-1) (U1 snRNP-binding protein homolog)	SNRNP35 HM1 U1SNRNPBP	Homo sapiens (Human)	246			mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type spliceosomal complex [GO:0005689]	mRNA binding [GO:0003729]; snRNA binding [GO:0017069]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type spliceosomal complex [GO:0005689]; mRNA binding [GO:0003729]; snRNA binding [GO:0017069]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15146077}.
Q16563	reviewed	SYPL1_HUMAN	Synaptophysin-like protein 1 (Pantophysin)	SYPL1 SYPL	Homo sapiens (Human)	259			chemical synaptic transmission [GO:0007268]	extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672]		extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672]; chemical synaptic transmission [GO:0007268]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Cytoplasmic transport vesicles (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.
Q16566	reviewed	KCC4_HUMAN	Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR)	CAMK4 CAMK CAMK-GR CAMKIV	Homo sapiens (Human)	473	FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}.		adaptive immune response [GO:0002250]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of osteoclast differentiation [GO:0045670]; regulation of T cell differentiation in thymus [GO:0033081]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]; adaptive immune response [GO:0002250]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of osteoclast differentiation [GO:0045670]; regulation of T cell differentiation in thymus [GO:0033081]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.
Q16568	reviewed	CART_HUMAN	Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39); CART(42-89)]	CARTPT CART	Homo sapiens (Human)	116	FUNCTION: Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro. {ECO:0000269|PubMed:9590691}.		adult feeding behavior [GO:0008343]; cell-cell signaling [GO:0007267]; cellular response to starvation [GO:0009267]; chemical synaptic transmission [GO:0007268]; circadian regulation of gene expression [GO:0032922]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular glucose homeostasis [GO:0001678]; negative regulation of appetite [GO:0032099]; negative regulation of bone resorption [GO:0045779]; negative regulation of glucagon secretion [GO:0070093]; negative regulation of osteoclast differentiation [GO:0045671]; neuropeptide signaling pathway [GO:0007218]; positive regulation of blood pressure [GO:0045777]; positive regulation of epinephrine secretion [GO:0032812]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of insulin secretion [GO:0050796]; signal transduction [GO:0007165]; somatostatin secretion [GO:0070253]	extracellular space [GO:0005615]; secretory granule [GO:0030141]; synapse [GO:0045202]	neuropeptide hormone activity [GO:0005184]	extracellular space [GO:0005615]; secretory granule [GO:0030141]; synapse [GO:0045202]; neuropeptide hormone activity [GO:0005184]; adult feeding behavior [GO:0008343]; cell-cell signaling [GO:0007267]; cellular response to starvation [GO:0009267]; chemical synaptic transmission [GO:0007268]; circadian regulation of gene expression [GO:0032922]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular glucose homeostasis [GO:0001678]; negative regulation of appetite [GO:0032099]; negative regulation of bone resorption [GO:0045779]; negative regulation of glucagon secretion [GO:0070093]; negative regulation of osteoclast differentiation [GO:0045671]; neuropeptide signaling pathway [GO:0007218]; positive regulation of blood pressure [GO:0045777]; positive regulation of epinephrine secretion [GO:0032812]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of insulin secretion [GO:0050796]; signal transduction [GO:0007165]; somatostatin secretion [GO:0070253]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q16570	reviewed	ACKR1_HUMAN	Atypical chemokine receptor 1 (Duffy antigen/chemokine receptor) (Fy glycoprotein) (GpFy) (Glycoprotein D) (Plasmodium vivax receptor) (CD antigen CD234)	ACKR1 DARC FY GPD	Homo sapiens (Human)	336	FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.		chemokine-mediated signaling pathway [GO:0070098]; defense response [GO:0006952]; inflammatory response [GO:0006954]; regulation of chemokine production [GO:0032642]	early endosome [GO:0005769]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	C-C chemokine binding [GO:0019957]; G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	early endosome [GO:0005769]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; C-C chemokine binding [GO:0019957]; G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; chemokine-mediated signaling pathway [GO:0070098]; defense response [GO:0006952]; inflammatory response [GO:0006954]; regulation of chemokine production [GO:0032642]	SUBCELLULAR LOCATION: Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Q16572	reviewed	VACHT_HUMAN	Vesicular acetylcholine transporter (VAChT) (Solute carrier family 18 member 3)	SLC18A3 VACHT	Homo sapiens (Human)	532	FUNCTION: Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis (PubMed:8910293, PubMed:20225888) (By similarity). Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern (By similarity). Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation (By similarity). Can transport serotonin. {ECO:0000250|UniProtKB:O35304, ECO:0000250|UniProtKB:Q62666, ECO:0000269|PubMed:20225888, ECO:0000269|PubMed:25355561, ECO:0000269|PubMed:8910293}.		acetylcholine uptake [GO:0051630]; chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neuromuscular junction development [GO:1904398]; serotonin uptake [GO:0051610]	AP-1 adaptor complex [GO:0030121]; AP-2 adaptor complex [GO:0030122]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-sculpted acetylcholine transport vesicle membrane [GO:0060201]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	acetylcholine transmembrane transporter activity [GO:0005277]; acetylcholine:proton antiporter activity [GO:0005278]; monoamine:proton antiporter activity [GO:0015311]	AP-1 adaptor complex [GO:0030121]; AP-2 adaptor complex [GO:0030122]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-sculpted acetylcholine transport vesicle membrane [GO:0060201]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; acetylcholine transmembrane transporter activity [GO:0005277]; acetylcholine:proton antiporter activity [GO:0005278]; monoamine:proton antiporter activity [GO:0015311]; acetylcholine uptake [GO:0051630]; chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neuromuscular junction development [GO:1904398]; serotonin uptake [GO:0051610]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q62666}; Multi-pass membrane protein {ECO:0000255}.
Q16576	reviewed	RBBP7_HUMAN	Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)	RBBP7 RBAP46	Homo sapiens (Human)	425	FUNCTION: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.		brain development [GO:0007420]; cellular heat acclimation [GO:0070370]; chromatin remodeling [GO:0006338]; DNA replication [GO:0006260]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of cell fate specification [GO:0042659]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; response to steroid hormone [GO:0048545]	ATPase complex [GO:1904949]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; NURF complex [GO:0016589]; Sin3 complex [GO:0016580]	histone binding [GO:0042393]; RNA binding [GO:0003723]	ATPase complex [GO:1904949]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; NURF complex [GO:0016589]; Sin3 complex [GO:0016580]; histone binding [GO:0042393]; RNA binding [GO:0003723]; brain development [GO:0007420]; cellular heat acclimation [GO:0070370]; chromatin remodeling [GO:0006338]; DNA replication [GO:0006260]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of cell fate specification [GO:0042659]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; response to steroid hormone [GO:0048545]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}.
Q16581	reviewed	C3AR_HUMAN	C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R)	C3AR1 AZ3B C3R1 HNFAG09	Homo sapiens (Human)	482	FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.		blood circulation [GO:0008015]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of vascular endothelial growth factor production [GO:0010575]	azurophil granule membrane [GO:0035577]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	complement component C3a receptor activity [GO:0004876]; complement component C5a receptor activity [GO:0004878]; G protein-coupled receptor activity [GO:0004930]	azurophil granule membrane [GO:0035577]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; complement component C3a receptor activity [GO:0004876]; complement component C5a receptor activity [GO:0004878]; G protein-coupled receptor activity [GO:0004930]; blood circulation [GO:0008015]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of vascular endothelial growth factor production [GO:0010575]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q16584	reviewed	M3K11_HUMAN	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)	MAP3K11 MLK3 PTK1 SPRK	Homo sapiens (Human)	847	FUNCTION: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}.		cell cycle G1/S phase transition [GO:0044843]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; microtubule-based process [GO:0007017]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron apoptotic process [GO:0043525]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]	centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]; cell cycle G1/S phase transition [GO:0044843]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; microtubule-based process [GO:0007017]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron apoptotic process [GO:0043525]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12529434}. Note=Location is cell cycle dependent.
Q16585	reviewed	SGCB_HUMAN	Beta-sarcoglycan (Beta-SG) (43 kDa dystrophin-associated glycoprotein) (43DAG) (A3b)	SGCB	Homo sapiens (Human)	318	FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.		cardiac muscle cell development [GO:0055013]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; glucose import in response to insulin stimulus [GO:0044381]; muscle organ development [GO:0007517]; response to glucose [GO:0009749]; vascular associated smooth muscle cell development [GO:0097084]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]; cardiac muscle cell development [GO:0055013]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; glucose import in response to insulin stimulus [GO:0044381]; muscle organ development [GO:0007517]; response to glucose [GO:0009749]; vascular associated smooth muscle cell development [GO:0097084]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Q16586	reviewed	SGCA_HUMAN	Alpha-sarcoglycan (Alpha-SG) (50 kDa dystrophin-associated glycoprotein) (50DAG) (Adhalin) (Dystroglycan-2)	SGCA ADL DAG2	Homo sapiens (Human)	387	FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.		muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; skeletal muscle tissue regeneration [GO:0043403]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; membrane raft [GO:0045121]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]	calcium ion binding [GO:0005509]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; membrane raft [GO:0045121]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]; calcium ion binding [GO:0005509]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; skeletal muscle tissue regeneration [GO:0043403]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Q16587	reviewed	ZNF74_HUMAN	Zinc finger protein 74 (Zinc finger protein 520) (hZNF7)	ZNF74 ZNF520	Homo sapiens (Human)	644	FUNCTION: May play a role in RNA metabolism.		regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	actin cytoskeleton [GO:0015629]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	actin cytoskeleton [GO:0015629]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q16594	reviewed	TAF9_HUMAN	Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (STAF31/32) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32)	TAF9 TAF2G TAFII31	Homo sapiens (Human)	264	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:15899866). TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes (PubMed:15899866). Essential for cell viability (PubMed:15899866). May have a role in gene regulation associated with apoptosis (PubMed:15899866). {ECO:0000269|PubMed:15899866, ECO:0000269|PubMed:33795473}.		box C/D snoRNP assembly [GO:0000492]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein stabilization [GO:0050821]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; response to interleukin-1 [GO:0070555]; response to L-glutamate [GO:1902065]; RNA polymerase II preinitiation complex assembly [GO:0051123]	MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]	ATPase binding [GO:0051117]; C2H2 zinc finger domain binding [GO:0070742]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]	MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; ATPase binding [GO:0051117]; C2H2 zinc finger domain binding [GO:0070742]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; box C/D snoRNP assembly [GO:0000492]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein stabilization [GO:0050821]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; response to interleukin-1 [GO:0070555]; response to L-glutamate [GO:1902065]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9674425}.
Q16595	reviewed	FRDA_HUMAN	Frataxin, mitochondrial (EC 1.16.3.1) (Friedreich ataxia protein) (Fxn) [Cleaved into: Frataxin intermediate form (i-FXN); Frataxin(56-210) (m56-FXN); Frataxin(78-210) (d-FXN) (m78-FXN); Frataxin mature form (Frataxin(81-210)) (m81-FXN); Extramitochondrial frataxin]	FXN FRDA X25	Homo sapiens (Human)	210	FUNCTION: [Frataxin mature form]: Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly (PubMed:24971490, PubMed:12785837). Accelerates sulfur transfer from NFS1 persulfide intermediate to ISCU and to small thiols such as L-cysteine and glutathione leading to persulfuration of these thiols and ultimately sulfide release (PubMed:24971490). Binds ferrous ion and is released from FXN upon the addition of both L-cysteine and reduced FDX2 during [2Fe-2S] cluster assembly (PubMed:29576242). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity (PubMed:15641778). May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems (PubMed:11823441, PubMed:12755598). May function as an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation (PubMed:15247478). May play a role as a high affinity iron binding partner for FECH that is capable of both delivering iron to ferrochelatase and mediating the terminal step in mitochondrial heme biosynthesis (PubMed:15123683, PubMed:16239244). {ECO:0000250|UniProtKB:Q9H1K1, ECO:0000269|PubMed:11823441, ECO:0000269|PubMed:12755598, ECO:0000269|PubMed:12785837, ECO:0000269|PubMed:15123683, ECO:0000269|PubMed:15247478, ECO:0000269|PubMed:15641778, ECO:0000269|PubMed:16239244, ECO:0000269|PubMed:24971490, ECO:0000269|PubMed:29576242}.; FUNCTION: [Extramitochondrial frataxin]: Modulates the RNA-binding activity of ACO1 (PubMed:20053667). May be involved in the cytoplasmic iron-sulfur protein biogenesis (PubMed:16091420). May contribute to oxidative stress resistance and overall cell survival (PubMed:16608849). {ECO:0000269|PubMed:16091420, ECO:0000269|PubMed:16608849, ECO:0000269|PubMed:20053667}.	MISCELLANEOUS: The unusual migration profile of mature frataxin on SDS-PAGE due to its acidic N-terminus most likely contributed to conflicting reports for the N-terminus of the mature protein. Unlike prokaryotic and yeast frataxin homologs, which self-assemble at high iron concentrations, oligomerization of human frataxin is not induced by iron. The existence of a specialized mitochondrial ferritin in mammalia (FTMT) is suggesting that iron storage would be redundant function, at least in mammalian mitochondria.; MISCELLANEOUS: [Isoform 2]: Not highly expressed and may be artifactual. {ECO:0000305}.	[2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; adult walking behavior [GO:0007628]; cellular response to hydrogen peroxide [GO:0070301]; embryo development ending in birth or egg hatching [GO:0009792]; heme biosynthetic process [GO:0006783]; intracellular iron ion homeostasis [GO:0006879]; iron incorporation into metallo-sulfur cluster [GO:0018283]; iron ion transmembrane transport [GO:0034755]; iron-sulfur cluster assembly [GO:0016226]; mitochondrion organization [GO:0007005]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of apoptotic process [GO:0043066]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of organ growth [GO:0046621]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; organ growth [GO:0035265]; oxidative phosphorylation [GO:0006119]; positive regulation of aconitate hydratase activity [GO:1904234]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of lyase activity [GO:0051349]; positive regulation of succinate dehydrogenase activity [GO:1904231]; proprioception [GO:0019230]; protein autoprocessing [GO:0016540]; regulation of ferrochelatase activity [GO:0010722]; response to iron ion [GO:0010039]	cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; L-cysteine desulfurase complex [GO:1990221]; mitochondrial iron-sulfur cluster assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	2 iron, 2 sulfur cluster binding [GO:0051537]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; iron chaperone activity [GO:0034986]	cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; L-cysteine desulfurase complex [GO:1990221]; mitochondrial iron-sulfur cluster assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; iron chaperone activity [GO:0034986]; [2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; adult walking behavior [GO:0007628]; cellular response to hydrogen peroxide [GO:0070301]; embryo development ending in birth or egg hatching [GO:0009792]; heme biosynthetic process [GO:0006783]; intracellular iron ion homeostasis [GO:0006879]; iron incorporation into metallo-sulfur cluster [GO:0018283]; iron ion transmembrane transport [GO:0034755]; iron-sulfur cluster assembly [GO:0016226]; mitochondrion organization [GO:0007005]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of apoptotic process [GO:0043066]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of organ growth [GO:0046621]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; organ growth [GO:0035265]; oxidative phosphorylation [GO:0006119]; positive regulation of aconitate hydratase activity [GO:1904234]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of lyase activity [GO:0051349]; positive regulation of succinate dehydrogenase activity [GO:1904231]; proprioception [GO:0019230]; protein autoprocessing [GO:0016540]; regulation of ferrochelatase activity [GO:0010722]; response to iron ion [GO:0010039]	SUBCELLULAR LOCATION: [Frataxin mature form]: Mitochondrion {ECO:0000269|PubMed:15581888, ECO:0000269|PubMed:16091420, ECO:0000269|PubMed:16608849, ECO:0000269|PubMed:18725397, ECO:0000269|PubMed:20053667, ECO:0000269|PubMed:21298097, ECO:0000269|PubMed:9241270, ECO:0000269|PubMed:9302253}.; SUBCELLULAR LOCATION: [Extramitochondrial frataxin]: Cytoplasm, cytosol {ECO:0000269|PubMed:16091420, ECO:0000269|PubMed:16608849, ECO:0000269|PubMed:20053667}.
Q16600	reviewed	ZN239_HUMAN	Zinc finger protein 239 (Zinc finger protein HOK-2) (Zinc finger protein MOK-2)	ZNF239 HOK2 MOK2	Homo sapiens (Human)	458	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q16602	reviewed	CALRL_HUMAN	Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)	CALCRL CGRPR	Homo sapiens (Human)	461	FUNCTION: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2 (PubMed:22102369, PubMed:30115739). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:22102369, PubMed:30115739). {ECO:0000250, ECO:0000269|PubMed:22102369, ECO:0000269|PubMed:30115739}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; angiogenesis [GO:0001525]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to sucrose stimulus [GO:0071329]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; heart development [GO:0007507]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; vascular associated smooth muscle cell proliferation [GO:1990874]	adrenomedullin receptor complex [GO:1903143]; CGRP receptor complex [GO:1990406]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	adrenomedullin binding [GO:1990409]; adrenomedullin receptor activity [GO:0001605]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948]; G protein-coupled receptor activity [GO:0004930]	adrenomedullin receptor complex [GO:1903143]; CGRP receptor complex [GO:1990406]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; adrenomedullin binding [GO:1990409]; adrenomedullin receptor activity [GO:0001605]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; angiogenesis [GO:0001525]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to sucrose stimulus [GO:0071329]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; heart development [GO:0007507]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; vascular associated smooth muscle cell proliferation [GO:1990874]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30115739}; Multi-pass membrane protein.
Q16610	reviewed	ECM1_HUMAN	Extracellular matrix protein 1 (Secretory component p85)	ECM1	Homo sapiens (Human)	540	FUNCTION: Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. {ECO:0000269|PubMed:11165938, ECO:0000269|PubMed:11292659, ECO:0000269|PubMed:16512877}.	MISCELLANEOUS: [Isoform 4]: May be due to intron retention. {ECO:0000305}.	angiogenesis [GO:0001525]; biomineral tissue development [GO:0031214]; chondrocyte development [GO:0002063]; endochondral bone growth [GO:0003416]; inflammatory response [GO:0006954]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of peptidase activity [GO:0010466]; ossification [GO:0001503]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of bone mineralization [GO:0030500]; regulation of T cell migration [GO:2000404]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type 2 immune response [GO:0002828]; signal transduction [GO:0007165]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089]	interleukin-2 receptor binding [GO:0005134]; protease binding [GO:0002020]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089]; interleukin-2 receptor binding [GO:0005134]; protease binding [GO:0002020]; angiogenesis [GO:0001525]; biomineral tissue development [GO:0031214]; chondrocyte development [GO:0002063]; endochondral bone growth [GO:0003416]; inflammatory response [GO:0006954]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of peptidase activity [GO:0010466]; ossification [GO:0001503]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of bone mineralization [GO:0030500]; regulation of T cell migration [GO:2000404]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type 2 immune response [GO:0002828]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q16611	reviewed	BAK_HUMAN	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)	BAK1 BAK BCL2L7 CDN1	Homo sapiens (Human)	211	FUNCTION: Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. {ECO:0000269|PubMed:17157251, ECO:0000269|PubMed:8521816}.		activation of cysteine-type endopeptidase activity [GO:0097202]; animal organ regeneration [GO:0031100]; apoptotic process [GO:0006915]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; apoptotic signaling pathway [GO:0097190]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell negative selection [GO:0002352]; blood vessel remodeling [GO:0001974]; calcium ion transport into cytosol [GO:0060402]; cellular response to mechanical stimulus [GO:0071260]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; endocrine pancreas development [GO:0031018]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial cell proliferation [GO:0050673]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fibroblast apoptotic process [GO:0044346]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; limb morphogenesis [GO:0035108]; mitochondrial fusion [GO:0008053]; myeloid cell homeostasis [GO:0002262]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of gene expression [GO:0010629]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; post-embryonic camera-type eye morphogenesis [GO:0048597]; regulation of cell cycle [GO:0051726]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; release of cytochrome c from mitochondria [GO:0001836]; response to ethanol [GO:0045471]; response to fungus [GO:0009620]; response to gamma radiation [GO:0010332]; response to hydrogen peroxide [GO:0042542]; response to mycotoxin [GO:0010046]; response to organic cyclic compound [GO:0014070]; response to UV-C [GO:0010225]; response to xenobiotic stimulus [GO:0009410]; thymocyte apoptotic process [GO:0070242]; vagina development [GO:0060068]	BAK complex [GO:0097145]; Bcl-2 family protein complex [GO:0097136]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; pore complex [GO:0046930]	BH domain binding [GO:0051400]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; porin activity [GO:0015288]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transmembrane transporter binding [GO:0044325]	BAK complex [GO:0097145]; Bcl-2 family protein complex [GO:0097136]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; pore complex [GO:0046930]; BH domain binding [GO:0051400]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; porin activity [GO:0015288]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transmembrane transporter binding [GO:0044325]; activation of cysteine-type endopeptidase activity [GO:0097202]; animal organ regeneration [GO:0031100]; apoptotic process [GO:0006915]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; apoptotic signaling pathway [GO:0097190]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell negative selection [GO:0002352]; blood vessel remodeling [GO:0001974]; calcium ion transport into cytosol [GO:0060402]; cellular response to mechanical stimulus [GO:0071260]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; endocrine pancreas development [GO:0031018]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial cell proliferation [GO:0050673]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fibroblast apoptotic process [GO:0044346]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; limb morphogenesis [GO:0035108]; mitochondrial fusion [GO:0008053]; myeloid cell homeostasis [GO:0002262]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of gene expression [GO:0010629]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; post-embryonic camera-type eye morphogenesis [GO:0048597]; regulation of cell cycle [GO:0051726]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; release of cytochrome c from mitochondria [GO:0001836]; response to ethanol [GO:0045471]; response to fungus [GO:0009620]; response to gamma radiation [GO:0010332]; response to hydrogen peroxide [GO:0042542]; response to mycotoxin [GO:0010046]; response to organic cyclic compound [GO:0014070]; response to UV-C [GO:0010225]; response to xenobiotic stimulus [GO:0009410]; thymocyte apoptotic process [GO:0070242]; vagina development [GO:0060068]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:29531808}; Single-pass membrane protein {ECO:0000255}.
Q16612	reviewed	NREP_HUMAN	Neuronal regeneration-related protein (Neuronal protein 3.1) (Protein p311)	NREP C5orf13 P311	Homo sapiens (Human)	68	FUNCTION: May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation. {ECO:0000250, ECO:0000269|PubMed:11358844, ECO:0000269|PubMed:16229809}.		axon regeneration [GO:0031103]; regulation of neuron differentiation [GO:0045664]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; axon regeneration [GO:0031103]; regulation of neuron differentiation [GO:0045664]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11358844}.
Q16613	reviewed	SNAT_HUMAN	Serotonin N-acetyltransferase (Serotonin acetylase) (EC 2.3.1.87) (Aralkylamine N-acetyltransferase) (AA-NAT)	AANAT SNAT	Homo sapiens (Human)	207	FUNCTION: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. {ECO:0000269|PubMed:11313340, ECO:0000305}.		cellular response to cAMP [GO:0071320]; circadian rhythm [GO:0007623]; indolalkylamine biosynthetic process [GO:0046219]; melatonin biosynthetic process [GO:0030187]; N-terminal protein amino acid acetylation [GO:0006474]; photoperiodism [GO:0009648]; response to calcium ion [GO:0051592]; response to copper ion [GO:0046688]; response to corticosterone [GO:0051412]; response to cytokine [GO:0034097]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416]; response to prostaglandin E [GO:0034695]; response to zinc ion [GO:0010043]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]	14-3-3 protein binding [GO:0071889]; aralkylamine N-acetyltransferase activity [GO:0004059]; arylamine N-acetyltransferase activity [GO:0004060]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; 14-3-3 protein binding [GO:0071889]; aralkylamine N-acetyltransferase activity [GO:0004059]; arylamine N-acetyltransferase activity [GO:0004060]; cellular response to cAMP [GO:0071320]; circadian rhythm [GO:0007623]; indolalkylamine biosynthetic process [GO:0046219]; melatonin biosynthetic process [GO:0030187]; N-terminal protein amino acid acetylation [GO:0006474]; photoperiodism [GO:0009648]; response to calcium ion [GO:0051592]; response to copper ion [GO:0046688]; response to corticosterone [GO:0051412]; response to cytokine [GO:0034097]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416]; response to prostaglandin E [GO:0034695]; response to zinc ion [GO:0010043]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11313340}.
Q16617	reviewed	NKG7_HUMAN	Protein NKG7 (G-CSF-induced gene 1 protein) (GIG-1 protein) (Granule membrane protein of 17 kDa) (GMP-17) (Natural killer cell protein 7) (p15-TIA-1)	NKG7 GIG1	Homo sapiens (Human)	165	FUNCTION: Regulates cytotoxic granule exocytosis in effector lymphocytes, thus acting as a critical mediator of inflammation in a broad range of infectious and non-infectious diseases (By similarity). Essential for cytotoxic degranulation of natural killer (NK) cells and CD8(+) T-cells and for the activation of CD4(+) T-cells following infection (By similarity). Plays a critical role in CD8(+) T-cell and NK cell-mediated cytolysis of target cells and contributes to the cytolytic activity via the perforin/granzyme pathway by enhancing exocytosis of LAMP1-carrying lytic granules (By similarity). Contributes to NK cell-mediated control of cancer metastasis (By similarity). {ECO:0000250|UniProtKB:Q99PA5}.		CD4-positive, alpha-beta T cell activation [GO:0035710]; defense response to protozoan [GO:0042832]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; inflammatory response [GO:0006954]; killing of cells of another organism [GO:0031640]; natural killer cell degranulation [GO:0043320]; natural killer cell mediated cytotoxicity [GO:0042267]; natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002420]; positive regulation of inflammatory response [GO:0050729]	cytolytic granule [GO:0044194]; cytolytic granule membrane [GO:0101004]; plasma membrane [GO:0005886]		cytolytic granule [GO:0044194]; cytolytic granule membrane [GO:0101004]; plasma membrane [GO:0005886]; CD4-positive, alpha-beta T cell activation [GO:0035710]; defense response to protozoan [GO:0042832]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; inflammatory response [GO:0006954]; killing of cells of another organism [GO:0031640]; natural killer cell degranulation [GO:0043320]; natural killer cell mediated cytotoxicity [GO:0042267]; natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002420]; positive regulation of inflammatory response [GO:0050729]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8570616}; Multi-pass membrane protein {ECO:0000269|PubMed:8570616}. Cytolytic granule membrane {ECO:0000269|PubMed:8570616}; Multi-pass membrane protein {ECO:0000269|PubMed:8570616}.
Q16619	reviewed	CTF1_HUMAN	Cardiotrophin-1 (CT-1)	CTF1	Homo sapiens (Human)	201	FUNCTION: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.		cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; muscle organ development [GO:0007517]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; leukemia inhibitory factor receptor binding [GO:0005146]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; leukemia inhibitory factor receptor binding [GO:0005146]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; muscle organ development [GO:0007517]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]	SUBCELLULAR LOCATION: Secreted.
Q16620	reviewed	NTRK2_HUMAN	BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)	NTRK2 TRKB	Homo sapiens (Human)	822	FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}.	MISCELLANEOUS: Trk also stands for tropomyosin-related kinase since the first Trk was isolated as an oncogenic protein which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1.; MISCELLANEOUS: [Isoform TrkB-T1]: Non-catalytic isoform. {ECO:0000305}.	brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cellular response to amino acid stimulus [GO:0071230]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; circadian rhythm [GO:0007623]; feeding behavior [GO:0007631]; glutamate secretion [GO:0014047]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; mechanoreceptor differentiation [GO:0042490]; myelination in peripheral nervous system [GO:0022011]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of anoikis [GO:2000811]; negative regulation of neuron apoptotic process [GO:0043524]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuronal action potential propagation [GO:0019227]; oligodendrocyte differentiation [GO:0048709]; peripheral nervous system neuron development [GO:0048935]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of GTPase activity [GO:0043087]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; retinal rod cell development [GO:0046548]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]; trans-synaptic signaling by neuropeptide, modulating synaptic transmission [GO:0099551]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasculogenesis [GO:0001570]	axon [GO:0030424]; axon terminus [GO:0043679]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; receptor complex [GO:0043235]; terminal bouton [GO:0043195]	ATP binding [GO:0005524]; brain-derived neurotrophic factor binding [GO:0048403]; brain-derived neurotrophic factor receptor activity [GO:0060175]; neurotrophin binding [GO:0043121]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; axon terminus [GO:0043679]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; receptor complex [GO:0043235]; terminal bouton [GO:0043195]; ATP binding [GO:0005524]; brain-derived neurotrophic factor binding [GO:0048403]; brain-derived neurotrophic factor receptor activity [GO:0060175]; neurotrophin binding [GO:0043121]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cellular response to amino acid stimulus [GO:0071230]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; circadian rhythm [GO:0007623]; feeding behavior [GO:0007631]; glutamate secretion [GO:0014047]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; mechanoreceptor differentiation [GO:0042490]; myelination in peripheral nervous system [GO:0022011]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of anoikis [GO:2000811]; negative regulation of neuron apoptotic process [GO:0043524]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuronal action potential propagation [GO:0019227]; oligodendrocyte differentiation [GO:0048709]; peripheral nervous system neuron development [GO:0048935]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of GTPase activity [GO:0043087]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; retinal rod cell development [GO:0046548]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]; trans-synaptic signaling by neuropeptide, modulating synaptic transmission [GO:0099551]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15494731}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000250|UniProtKB:P15209}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P15209}. Early endosome membrane {ECO:0000250|UniProtKB:P15209}. Cell projection, axon {ECO:0000250|UniProtKB:Q63604}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63604}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q63604}. Postsynaptic density {ECO:0000250|UniProtKB:P15209}. Note=Internalized to endosomes upon ligand-binding. {ECO:0000250|UniProtKB:P15209}.
Q16621	reviewed	NFE2_HUMAN	Transcription factor NF-E2 45 kDa subunit (Leucine zipper protein NF-E2) (Nuclear factor, erythroid-derived 2 45 kDa subunit) (p45 NF-E2)	NFE2	Homo sapiens (Human)	373	FUNCTION: Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. {ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:16287851}.		hemostasis [GO:0007599]; integrated stress response signaling [GO:0140467]; nucleosome disassembly [GO:0006337]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; WW domain binding [GO:0050699]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; WW domain binding [GO:0050699]; hemostasis [GO:0007599]; integrated stress response signaling [GO:0140467]; nucleosome disassembly [GO:0006337]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.
Q16623	reviewed	STX1A_HUMAN	Syntaxin-1A (Neuron-specific antigen HPC-1)	STX1A STX1	Homo sapiens (Human)	288	FUNCTION: Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). {ECO:0000250|UniProtKB:O35526, ECO:0000269|PubMed:23091057, ECO:0000269|PubMed:26635000}.	MISCELLANEOUS: [Isoform 2]: Expression is up-regulated by phorbol 12-myristate 13-acetate (PMA), but not by forskolin. {ECO:0000305}.	calcium-ion regulated exocytosis [GO:0017156]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of catecholamine secretion [GO:0033605]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of norepinephrine secretion [GO:0010701]; protein sumoylation [GO:0016925]; regulation of insulin secretion [GO:0050796]; regulation of synaptic vesicle priming [GO:0010807]; secretion by cell [GO:0032940]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]	axon [GO:0030424]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; extracellular region [GO:0005576]; neuron projection [GO:0043005]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]	calcium channel inhibitor activity [GO:0019855]; chloride channel inhibitor activity [GO:0019869]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	axon [GO:0030424]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; extracellular region [GO:0005576]; neuron projection [GO:0043005]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]; calcium channel inhibitor activity [GO:0019855]; chloride channel inhibitor activity [GO:0019869]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; calcium-ion regulated exocytosis [GO:0017156]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of catecholamine secretion [GO:0033605]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of norepinephrine secretion [GO:0010701]; protein sumoylation [GO:0016925]; regulation of insulin secretion [GO:0050796]; regulation of synaptic vesicle priming [GO:0010807]; secretion by cell [GO:0032940]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O35526}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:O35526}. Synapse, synaptosome {ECO:0000250|UniProtKB:O35526}. Cell membrane {ECO:0000250|UniProtKB:P32851}. Note=Colocalizes with KCNB1 at the cell membrane. {ECO:0000250|UniProtKB:P32851}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q16625	reviewed	OCLN_HUMAN	Occludin	OCLN	Homo sapiens (Human)	522	FUNCTION: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}.		bicellular tight junction assembly [GO:0070830]; cell-cell junction organization [GO:0045216]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of blood-brain barrier permeability [GO:1905605]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of wound healing [GO:0090303]; protein localization to cell leading edge [GO:1902463]; protein-containing complex assembly [GO:0065003]; regulation of glucose transmembrane transport [GO:0010827]	apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; endocytic vesicle [GO:0030139]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]	protein domain specific binding [GO:0019904]	apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; endocytic vesicle [GO:0030139]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]; protein domain specific binding [GO:0019904]; bicellular tight junction assembly [GO:0070830]; cell-cell junction organization [GO:0045216]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of blood-brain barrier permeability [GO:1905605]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of wound healing [GO:0090303]; protein localization to cell leading edge [GO:1902463]; protein-containing complex assembly [GO:0065003]; regulation of glucose transmembrane transport [GO:0010827]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19017651, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:9175707}; Multi-pass membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:10523508, ECO:0000269|PubMed:19017651, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:9175707}.
Q16627	reviewed	CCL14_HUMAN	C-C motif chemokine 14 (Chemokine CC-1/CC-3) (HCC-1/HCC-3) (HCC-1(1-74)) (NCC-2) (Small-inducible cytokine A14) [Cleaved into: HCC-1(3-74); HCC-1(4-74); HCC-1(9-74)]	CCL14 NCC2 SCYA14	Homo sapiens (Human)	93	FUNCTION: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. {ECO:0000269|PubMed:11085751}.		cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]	extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	SUBCELLULAR LOCATION: Secreted.
Q16629	reviewed	SRSF7_HUMAN	Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)	SRSF7 SFRS7	Homo sapiens (Human)	238	FUNCTION: Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:12667464, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:18364396}.		cellular response to leukemia inhibitory factor [GO:1990830]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; cellular response to leukemia inhibitory factor [GO:1990830]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11336712}. Cytoplasm {ECO:0000269|PubMed:11336712}.
Q16630	reviewed	CPSF6_HUMAN	Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)	CPSF6 CFIM68	Homo sapiens (Human)	551	FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460). {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). {ECO:0000269|PubMed:24130490}.		localization [GO:0051179]; messenger ribonucleoprotein complex assembly [GO:1990120]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; mRNA processing [GO:0006397]; positive regulation of RNA export from nucleus [GO:0046833]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]	cytoplasm [GO:0005737]; interchromatin granule [GO:0035061]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; perichromatin fibrils [GO:0005726]; ribonucleoprotein complex [GO:1990904]	exon-exon junction complex binding [GO:1990448]; mRNA binding [GO:0003729]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; interchromatin granule [GO:0035061]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; perichromatin fibrils [GO:0005726]; ribonucleoprotein complex [GO:1990904]; exon-exon junction complex binding [GO:1990448]; mRNA binding [GO:0003729]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; localization [GO:0051179]; messenger ribonucleoprotein complex assembly [GO:1990120]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; mRNA processing [GO:0006397]; positive regulation of RNA export from nucleus [GO:0046833]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:30916345, ECO:0000269|PubMed:9659921}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17267687}. Nucleus speckle {ECO:0000269|PubMed:17267687}. Cytoplasm {ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:30916345}. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). Colocalizes with PSPC1 in punctate subnuclear structures often located adjacent to nuclear speckles, called paraspeckles, and corresponding to interchromatin granules-associated zones (IGAZs) (PubMed:17267687). Distribution in speckles and paraspeckles varies during the cell cycle (PubMed:17267687). Associates at sites of active transcription on nascent perichromatin fibrils (PFs) and perichromatin granules (PubMed:17267687). Nuclear import is mediated via interaction with TNPO3 independently of CPSF6 phosphorylation status (PubMed:30916345). {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:17267687, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:30916345}.
Q16633	reviewed	OBF1_HUMAN	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)	POU2AF1 BOB1 OBF1	Homo sapiens (Human)	256	FUNCTION: Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290). It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176). It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 (PubMed:7779176). It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:7623806, PubMed:7859290). Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity). {ECO:0000250|UniProtKB:Q64693, ECO:0000269|PubMed:7623806, ECO:0000269|PubMed:7779176, ECO:0000269|PubMed:7859290}.		cellular response to virus [GO:0098586]; germinal center B cell differentiation [GO:0002314]; humoral immune response [GO:0006959]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944]	RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; POU domain binding [GO:0070974]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; POU domain binding [GO:0070974]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; cellular response to virus [GO:0098586]; germinal center B cell differentiation [GO:0002314]; humoral immune response [GO:0006959]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q16635	reviewed	TAZ_HUMAN	Tafazzin (Taz) (EC 2.3.1.-) (Protein G4.5)	TAFAZZIN EFE2 G4.5 TAZ	Homo sapiens (Human)	262	FUNCTION: Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (PubMed:12930833, PubMed:19700766, PubMed:19164547, PubMed:26908608, PubMed:33096711). Its role in cellular physiology is to improve mitochondrial performance (PubMed:32234310). CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity). Catalyzes the transacylation between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor. CoA-independent, it can reshuffle molecular species within a single phospholipid class. Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes. Essential for the final stage of spermatogenesis, spermatid individualization (By similarity). Required for the initiation of mitophagy (PubMed:33096711). Required to ensure progression of spermatocytes through meiosis (By similarity). Exon 7 of human tafazzin is essential for catalysis (PubMed:19700766). {ECO:0000250|UniProtKB:Q06510, ECO:0000250|UniProtKB:Q91WF0, ECO:0000250|UniProtKB:Q9V6G5, ECO:0000269|PubMed:12930833, ECO:0000269|PubMed:19164547, ECO:0000269|PubMed:19700766, ECO:0000269|PubMed:26908608, ECO:0000269|PubMed:33096711, ECO:0000303|PubMed:19700766, ECO:0000303|PubMed:32234310}.; FUNCTION: [Isoform 1]: Catalyzes the transacylation between lysophosphatidate (such as 1-acyl-sn-glycero-3-phosphate) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)) (PubMed:19700766). Contributes to cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL) remodeling (PubMed:12930833, PubMed:19700766). {ECO:0000269|PubMed:12930833, ECO:0000269|PubMed:19700766}.; FUNCTION: [Isoform 3]: Catalyzes the transacylation between lysophospholipids and phospholipids, and plays a fundamental role in cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL) metabolism and remodeling. {ECO:0000269|PubMed:12930833, ECO:0000269|PubMed:19416660, ECO:0000269|PubMed:19700766}.; FUNCTION: [Isoform 5]: Catalytically inactive. {ECO:0000269|PubMed:12930833, ECO:0000269|PubMed:19700766}.; FUNCTION: [Isoform 7]: Catalytically inactive. {ECO:0000269|PubMed:19700766}.	MISCELLANEOUS: The enzyme was named after a masochistic character Tafazzi, once popular on Italian television, apparently due to the difficulty encountered for its identification and characterization. {ECO:0000303|PubMed:8630491}.	cardiac muscle contraction [GO:0060048]; cardiac muscle tissue development [GO:0048738]; cardiolipin acyl-chain remodeling [GO:0035965]; cardiolipin biosynthetic process [GO:0032049]; cardiolipin metabolic process [GO:0032048]; cristae formation [GO:0042407]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; hemopoiesis [GO:0030097]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; muscle contraction [GO:0006936]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of cardiolipin metabolic process [GO:1900210]; skeletal muscle tissue development [GO:0007519]; spermatocyte division [GO:0048137]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; O-acyltransferase activity [GO:0008374]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; O-acyltransferase activity [GO:0008374]; cardiac muscle contraction [GO:0060048]; cardiac muscle tissue development [GO:0048738]; cardiolipin acyl-chain remodeling [GO:0035965]; cardiolipin biosynthetic process [GO:0032049]; cardiolipin metabolic process [GO:0032048]; cristae formation [GO:0042407]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; hemopoiesis [GO:0030097]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; muscle contraction [GO:0006936]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of cardiolipin metabolic process [GO:1900210]; skeletal muscle tissue development [GO:0007519]; spermatocyte division [GO:0048137]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:26908608}; Peripheral membrane protein {ECO:0000305|PubMed:26908608}; Intermembrane side {ECO:0000305|PubMed:26908608}. Mitochondrion inner membrane {ECO:0000269|PubMed:26908608}; Peripheral membrane protein {ECO:0000305|PubMed:26908608}; Intermembrane side {ECO:0000305|PubMed:26908608}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion membrane {ECO:0000269|PubMed:19700766, ECO:0000269|PubMed:29129703}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion membrane {ECO:0000269|PubMed:19700766, ECO:0000269|PubMed:29129703}.; SUBCELLULAR LOCATION: [Isoform 5]: Mitochondrion membrane {ECO:0000269|PubMed:19700766}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Mitochondrion membrane {ECO:0000269|PubMed:19700766}.; SUBCELLULAR LOCATION: [Isoform 8]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 9]: Cytoplasm {ECO:0000305}.
Q16637	reviewed	SMN_HUMAN	Survival motor neuron protein (Component of gems 1) (Gemin-1)	SMN1 SMN SMNT; SMN2 SMNC	Homo sapiens (Human)	294	FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:9845364, PubMed:18984161). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits (PubMed:21816274, PubMed:22101937, PubMed:17178713). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development (PubMed:23063131). Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:17178713, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:22101937, ECO:0000269|PubMed:23063131, ECO:0000269|PubMed:26700805, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9845364}.	MISCELLANEOUS: The SMN gene is present in two highly homologous and functional copies (TelSMN/SMN1 and CenSMN/SMN2). The telomeric copy of SMN gene (TelSMN/SMN1) seems to be the SMA-determining gene while the centromeric copy seems unaffected.; MISCELLANEOUS: [Isoform SMN]: Primarily derived from SMN1 gene.; MISCELLANEOUS: [Isoform SMN-delta7]: Thought to be a non-functional protein that lacks the capacity to oligomerize and thus cannot interact with Sm proteins. Primarily derived from SMN2 gene. {ECO:0000305|PubMed:10500148}.	DNA-templated transcription termination [GO:0006353]; nervous system development [GO:0007399]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]	axon [GO:0030424]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; neuron projection [GO:0043005]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; Z disc [GO:0030018]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	axon [GO:0030424]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; neuron projection [GO:0043005]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; Z disc [GO:0030018]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; DNA-templated transcription termination [GO:0006353]; nervous system development [GO:0007399]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Nucleus, gem {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:8670859, ECO:0000305|PubMed:12067652}. Nucleus, Cajal body {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:21072240, ECO:0000305|PubMed:12067652}. Cytoplasm {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:8670859, ECO:0000305|PubMed:12067652}. Cytoplasmic granule {ECO:0000269|PubMed:14715275}. Perikaryon {ECO:0000269|PubMed:18093976}. Cell projection, neuron projection {ECO:0000269|PubMed:18093976}. Cell projection, axon {ECO:0000250|UniProtKB:P97801}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:P97801}. Note=Colocalizes with actin and at the Z-line of skeletal muscle (By similarity). Under stress conditions colocalizes with RPP20/POP7 in punctuated cytoplasmic granules (PubMed:14715275). Colocalized and redistributed with ZPR1 from the cytoplasm to nuclear gems (Gemini of coiled bodies) and Cajal bodies (PubMed:11283611). Colocalizes with FMR1 in cytoplasmic granules in the soma and neurite cell processes (PubMed:18093976). {ECO:0000250|UniProtKB:P97801, ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:14715275, ECO:0000269|PubMed:18093976}.
Q16643	reviewed	DREB_HUMAN	Drebrin (Developmentally-regulated brain protein)	DBN1 D0S117E	Homo sapiens (Human)	649	FUNCTION: Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}.		actin filament organization [GO:0007015]; cell communication by chemical coupling [GO:0010643]; cell communication by electrical coupling [GO:0010644]; cytoplasmic sequestering of protein [GO:0051220]; generation of neurons [GO:0048699]; in utero embryonic development [GO:0001701]; maintenance of protein location in cell [GO:0032507]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of synaptic plasticity [GO:0031915]; regulation of dendrite development [GO:0050773]; regulation of neuronal synaptic plasticity [GO:0048168]	actin cytoskeleton [GO:0015629]; actomyosin [GO:0042641]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; gap junction [GO:0005921]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]	actin binding [GO:0003779]; cadherin binding [GO:0045296]; profilin binding [GO:0005522]	actin cytoskeleton [GO:0015629]; actomyosin [GO:0042641]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; gap junction [GO:0005921]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; profilin binding [GO:0005522]; actin filament organization [GO:0007015]; cell communication by chemical coupling [GO:0010643]; cell communication by electrical coupling [GO:0010644]; cytoplasmic sequestering of protein [GO:0051220]; generation of neurons [GO:0048699]; in utero embryonic development [GO:0001701]; maintenance of protein location in cell [GO:0032507]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of synaptic plasticity [GO:0031915]; regulation of dendrite development [GO:0050773]; regulation of neuronal synaptic plasticity [GO:0048168]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20215400, ECO:0000269|PubMed:28966017, ECO:0000269|PubMed:8838578}. Cell projection, dendrite {ECO:0000269|PubMed:8838578}. Cytoplasm, cell cortex {ECO:0000269|PubMed:20215400}. Cell junction {ECO:0000269|PubMed:20215400}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9QXS6}. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm (PubMed:20215400). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400). Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}.
Q16644	reviewed	MAPK3_HUMAN	MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)	MAPKAPK3	Homo sapiens (Human)	382	FUNCTION: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:15563468, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20599781, ECO:0000269|PubMed:8626550, ECO:0000269|PubMed:8774846}.		intracellular signal transduction [GO:0035556]; macropinocytosis [GO:0044351]; peptidyl-serine phosphorylation [GO:0018105]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase binding [GO:0051019]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase binding [GO:0051019]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; macropinocytosis [GO:0044351]; peptidyl-serine phosphorylation [GO:0018105]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15302577, ECO:0000269|PubMed:26744326}. Cytoplasm {ECO:0000269|PubMed:15302577, ECO:0000269|PubMed:26744326}. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
Q16647	reviewed	PTGIS_HUMAN	Prostacyclin synthase (EC 5.3.99.4) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Prostaglandin I2 synthase)	PTGIS CYP8 CYP8A1	Homo sapiens (Human)	500	FUNCTION: Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:18032380, PubMed:25623425, PubMed:12372404, PubMed:15115769). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323). {ECO:0000269|PubMed:12372404, ECO:0000269|PubMed:15115769, ECO:0000269|PubMed:17459323, ECO:0000269|PubMed:18032380, ECO:0000269|PubMed:25623425}.		apoptotic signaling pathway [GO:0097190]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cyclooxygenase pathway [GO:0019371]; icosanoid metabolic process [GO:0006690]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; positive regulation of angiogenesis [GO:0045766]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; prostaglandin biosynthetic process [GO:0001516]	caveola [GO:0005901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; nucleus [GO:0005634]	heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; prostaglandin-I synthase activity [GO:0008116]	caveola [GO:0005901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; nucleus [GO:0005634]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; prostaglandin-I synthase activity [GO:0008116]; apoptotic signaling pathway [GO:0097190]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cyclooxygenase pathway [GO:0019371]; icosanoid metabolic process [GO:0006690]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; positive regulation of angiogenesis [GO:0045766]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; prostaglandin biosynthetic process [GO:0001516]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q29626}; Single-pass membrane protein {ECO:0000255}.
Q16649	reviewed	NFIL3_HUMAN	Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A)	NFIL3 E4BP4 IL3BP1	Homo sapiens (Human)	462	FUNCTION: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). {ECO:0000250|UniProtKB:O08750, ECO:0000269|PubMed:1620116, ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}.		cellular response to interleukin-4 [GO:0071353]; circadian rhythm [GO:0007623]; immune response [GO:0006955]; natural killer cell differentiation [GO:0001779]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cellular response to interleukin-4 [GO:0071353]; circadian rhythm [GO:0007623]; immune response [GO:0006955]; natural killer cell differentiation [GO:0001779]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Q16650	reviewed	TBR1_HUMAN	T-box brain protein 1 (T-brain-1) (TBR-1) (TES-56)	TBR1	Homo sapiens (Human)	682	FUNCTION: Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:25232744, PubMed:30250039). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity). {ECO:0000250|UniProtKB:Q64336, ECO:0000269|PubMed:25232744, ECO:0000269|PubMed:30250039}.		amygdala development [GO:0021764]; brain development [GO:0007420]; cell fate specification [GO:0001708]; cerebral cortex development [GO:0021987]; chromatin remodeling [GO:0006338]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; conditioned taste aversion [GO:0001661]; gene expression [GO:0010467]; hindbrain development [GO:0030902]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of axon guidance [GO:1902667]; regulation of neuron projection development [GO:0010975]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of animal organ identity [GO:0010092]	nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; amygdala development [GO:0021764]; brain development [GO:0007420]; cell fate specification [GO:0001708]; cerebral cortex development [GO:0021987]; chromatin remodeling [GO:0006338]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; conditioned taste aversion [GO:0001661]; gene expression [GO:0010467]; hindbrain development [GO:0030902]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of axon guidance [GO:1902667]; regulation of neuron projection development [GO:0010975]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of animal organ identity [GO:0010092]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25232744, ECO:0000269|PubMed:30250039}.
Q16651	reviewed	PRSS8_HUMAN	Prostasin (EC 3.4.21.-) (Channel-activating protease 1) (CAP1) (Serine protease 8) [Cleaved into: Prostasin light chain; Prostasin heavy chain]	PRSS8	Homo sapiens (Human)	343	FUNCTION: Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). {ECO:0000269|PubMed:15246975, ECO:0000269|PubMed:15474520}.		positive regulation of sodium ion transport [GO:0010765]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; positive regulation of sodium ion transport [GO:0010765]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: [Prostasin]: Cell membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Prostasin light chain]: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.; SUBCELLULAR LOCATION: [Prostasin heavy chain]: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Q16653	reviewed	MOG_HUMAN	Myelin-oligodendrocyte glycoprotein	MOG	Homo sapiens (Human)	247	FUNCTION: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. {ECO:0000250}.; FUNCTION: (Microbial infection) Acts as a receptor for rubella virus. {ECO:0000269|PubMed:21880773}.	MISCELLANEOUS: [Isoform 9]: Not functionally active. May be expressed at low level in the adult. {ECO:0000305}.; MISCELLANEOUS: [Isoform 10]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 8]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 9]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q16654	reviewed	PDK4_HUMAN	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)	PDK4 PDHK4	Homo sapiens (Human)	411	FUNCTION: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. {ECO:0000269|PubMed:15955060, ECO:0000269|PubMed:18658136, ECO:0000269|PubMed:21816445, ECO:0000269|PubMed:21852536}.		cellular response to fatty acid [GO:0071398]; cellular response to starvation [GO:0009267]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; negative regulation of anoikis [GO:2000811]; phosphorylation [GO:0016310]; reactive oxygen species metabolic process [GO:0072593]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of bone resorption [GO:0045124]; regulation of cellular ketone metabolic process [GO:0010565]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of fatty acid oxidation [GO:0046320]; regulation of glucose metabolic process [GO:0010906]; regulation of pH [GO:0006885]; response to starvation [GO:0042594]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740]; cellular response to fatty acid [GO:0071398]; cellular response to starvation [GO:0009267]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; negative regulation of anoikis [GO:2000811]; phosphorylation [GO:0016310]; reactive oxygen species metabolic process [GO:0072593]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of bone resorption [GO:0045124]; regulation of cellular ketone metabolic process [GO:0010565]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of fatty acid oxidation [GO:0046320]; regulation of glucose metabolic process [GO:0010906]; regulation of pH [GO:0006885]; response to starvation [GO:0042594]	SUBCELLULAR LOCATION: Mitochondrion matrix.
Q16655	reviewed	MAR1_HUMAN	Melanoma antigen recognized by T-cells 1 (MART-1) (Antigen LB39-AA) (Antigen SK29-AA) (Protein Melan-A)	MLANA MART1	Homo sapiens (Human)	118	FUNCTION: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. {ECO:0000269|PubMed:15695812, ECO:0000269|PubMed:19717472}.			endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]		endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
Q16656	reviewed	NRF1_HUMAN	Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal)	NRF1	Homo sapiens (Human)	503	FUNCTION: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q16658	reviewed	FSCN1_HUMAN	Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55)	FSCN1 FAN1 HSN SNL	Homo sapiens (Human)	493	FUNCTION: Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}.		actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; cell motility [GO:0048870]; cell-cell junction assembly [GO:0007043]; establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of cell polarity [GO:0007163]; microspike assembly [GO:0030035]; parallel actin filament bundle assembly [GO:0030046]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of podosome assembly [GO:0071803]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of microvillus assembly [GO:0032534]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; microspike [GO:0044393]; microvillus [GO:0005902]; podosome [GO:0002102]; ruffle [GO:0001726]; stress fiber [GO:0001725]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; microspike [GO:0044393]; microvillus [GO:0005902]; podosome [GO:0002102]; ruffle [GO:0001726]; stress fiber [GO:0001725]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; cell motility [GO:0048870]; cell-cell junction assembly [GO:0007043]; establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of cell polarity [GO:0007163]; microspike assembly [GO:0030035]; parallel actin filament bundle assembly [GO:0030046]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of podosome assembly [GO:0071803]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of microvillus assembly [GO:0032534]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21706053, ECO:0000269|PubMed:9571235}. Cytoplasm, cell cortex {ECO:0000269|PubMed:21685497}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:3525578, ECO:0000269|PubMed:9571235}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:21706053}. Cell projection, filopodium {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:3525578}. Cell projection, invadopodium {ECO:0000269|PubMed:20137952}. Cell projection, microvillus {ECO:0000269|PubMed:9571235}. Cell junction {ECO:0000269|PubMed:9571235}. Note=Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity). {ECO:0000250|UniProtKB:Q61553, ECO:0000269|PubMed:21706053}.
Q16659	reviewed	MK06_HUMAN	Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK)	MAPK6 ERK3 PRKM6	Homo sapiens (Human)	721	FUNCTION: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}.		cell cycle [GO:0007049]; intracellular signal transduction [GO:0035556]; positive regulation of dendritic spine development [GO:0060999]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; septin cytoskeleton [GO:0032156]	ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; septin cytoskeleton [GO:0032156]; ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell cycle [GO:0007049]; intracellular signal transduction [GO:0035556]; positive regulation of dendritic spine development [GO:0060999]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}.
Q16663	reviewed	CCL15_HUMAN	C-C motif chemokine 15 (Chemokine CC-2) (HCC-2) (Leukotactin-1) (LKN-1) (MIP-1 delta) (Macrophage inflammatory protein 5) (MIP-5) (Mrp-2b) (NCC-3) (Small-inducible cytokine A15) [Cleaved into: CCL15(22-92); CCL15(25-92); CCL15(29-92)]	CCL15 MIP5 NCC3 SCYA15	Homo sapiens (Human)	113	FUNCTION: Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the CCL15. {ECO:0000269|PubMed:15905581}.		cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; signal transduction [GO:0007165]	extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102]	extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
Q16665	reviewed	HIF1A_HUMAN	Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)	HIF1A BHLHE78 MOP1 PASD8	Homo sapiens (Human)	826	FUNCTION: Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:9887100, PubMed:30125331). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:9887100, PubMed:30125331). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:9887100, PubMed:16543236). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}.	MISCELLANEOUS: [Isoform 3]: Up-regulated in peripheral T-lymphocytes after T-cell receptor stimulation. Highest expression in peripheral blood leukocytes and thymus. {ECO:0000305}.	angiogenesis [GO:0001525]; axonal transport of mitochondrion [GO:0019896]; B-1 B cell homeostasis [GO:0001922]; bone mineralization [GO:0030282]; cardiac ventricle morphogenesis [GO:0003208]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to virus [GO:0098586]; cerebral cortex development [GO:0021987]; chondrocyte differentiation [GO:0002062]; collagen metabolic process [GO:0032963]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; digestive tract morphogenesis [GO:0048546]; dopaminergic neuron differentiation [GO:0071542]; elastin metabolic process [GO:0051541]; embryonic hemopoiesis [GO:0035162]; embryonic placenta development [GO:0001892]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; epithelial to mesenchymal transition [GO:0001837]; glandular epithelial cell maturation [GO:0002071]; heart looping [GO:0001947]; hemoglobin biosynthetic process [GO:0042541]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; intestinal epithelial cell maturation [GO:0060574]; intracellular glucose homeostasis [GO:0001678]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; iris morphogenesis [GO:0061072]; lactate metabolic process [GO:0006089]; lactation [GO:0007595]; mesenchymal cell apoptotic process [GO:0097152]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of bone mineralization [GO:0030502]; negative regulation of gene expression [GO:0010629]; negative regulation of growth [GO:0045926]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of TOR signaling [GO:0032007]; neural crest cell migration [GO:0001755]; neural fold elevation formation [GO:0021502]; neuroblast proliferation [GO:0007405]; neuron apoptotic process [GO:0051402]; outflow tract morphogenesis [GO:0003151]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of chemokine production [GO:0032722]; positive regulation of chemokine-mediated signaling pathway [GO:0070101]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of macroautophagy [GO:0016239]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of aerobic respiration [GO:1903715]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of glycolytic process [GO:0006110]; regulation of protein neddylation [GO:2000434]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to muscle activity [GO:0014850]; response to reactive oxygen species [GO:0000302]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; TOR signaling [GO:0031929]; vascular endothelial growth factor production [GO:0010573]; visual learning [GO:0008542]	axon cytoplasm [GO:1904115]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; motile cilium [GO:0031514]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; Hsp90 protein binding [GO:0051879]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator binding [GO:0001223]; transcription regulator activator activity [GO:0140537]; ubiquitin protein ligase binding [GO:0031625]	axon cytoplasm [GO:1904115]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; motile cilium [GO:0031514]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; Hsp90 protein binding [GO:0051879]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator binding [GO:0001223]; transcription regulator activator activity [GO:0140537]; ubiquitin protein ligase binding [GO:0031625]; angiogenesis [GO:0001525]; axonal transport of mitochondrion [GO:0019896]; B-1 B cell homeostasis [GO:0001922]; bone mineralization [GO:0030282]; cardiac ventricle morphogenesis [GO:0003208]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to virus [GO:0098586]; cerebral cortex development [GO:0021987]; chondrocyte differentiation [GO:0002062]; collagen metabolic process [GO:0032963]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; digestive tract morphogenesis [GO:0048546]; dopaminergic neuron differentiation [GO:0071542]; elastin metabolic process [GO:0051541]; embryonic hemopoiesis [GO:0035162]; embryonic placenta development [GO:0001892]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; epithelial to mesenchymal transition [GO:0001837]; glandular epithelial cell maturation [GO:0002071]; heart looping [GO:0001947]; hemoglobin biosynthetic process [GO:0042541]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; intestinal epithelial cell maturation [GO:0060574]; intracellular glucose homeostasis [GO:0001678]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; iris morphogenesis [GO:0061072]; lactate metabolic process [GO:0006089]; lactation [GO:0007595]; mesenchymal cell apoptotic process [GO:0097152]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of bone mineralization [GO:0030502]; negative regulation of gene expression [GO:0010629]; negative regulation of growth [GO:0045926]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of TOR signaling [GO:0032007]; neural crest cell migration [GO:0001755]; neural fold elevation formation [GO:0021502]; neuroblast proliferation [GO:0007405]; neuron apoptotic process [GO:0051402]; outflow tract morphogenesis [GO:0003151]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of chemokine production [GO:0032722]; positive regulation of chemokine-mediated signaling pathway [GO:0070101]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of macroautophagy [GO:0016239]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of aerobic respiration [GO:1903715]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of glycolytic process [GO:0006110]; regulation of protein neddylation [GO:2000434]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to muscle activity [GO:0014850]; response to reactive oxygen species [GO:0000302]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; TOR signaling [GO:0031929]; vascular endothelial growth factor production [GO:0010573]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9822602}. Nucleus {ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:9822602}. Nucleus speckle {ECO:0000250|UniProtKB:Q61221}. Note=Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia (PubMed:9822602). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:9822602}.
Q16666	reviewed	IF16_HUMAN	Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator)	IFI16 IFNGIP1	Homo sapiens (Human)	785	FUNCTION: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}.	MISCELLANEOUS: [Isoform 2]: Major isoform. {ECO:0000305}.	activation of cysteine-type endopeptidase activity [GO:0097202]; activation of innate immune response [GO:0002218]; autophagy [GO:0006914]; cellular response to glucose starvation [GO:0042149]; cellular response to interferon-beta [GO:0035458]; cellular response to ionizing radiation [GO:0071479]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; monocyte differentiation [GO:0030224]; myeloid cell differentiation [GO:0030099]; negative regulation of AIM2 inflammasome complex assembly [GO:0140972]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral genome replication [GO:0045071]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of autophagy [GO:0010506]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription factor binding [GO:0008134]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription factor binding [GO:0008134]; activation of cysteine-type endopeptidase activity [GO:0097202]; activation of innate immune response [GO:0002218]; autophagy [GO:0006914]; cellular response to glucose starvation [GO:0042149]; cellular response to interferon-beta [GO:0035458]; cellular response to ionizing radiation [GO:0071479]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; monocyte differentiation [GO:0030224]; myeloid cell differentiation [GO:0030099]; negative regulation of AIM2 inflammasome complex assembly [GO:0140972]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral genome replication [GO:0045071]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:24531343, ECO:0000269|PubMed:7536752}. Cytoplasm {ECO:0000269|PubMed:22691496}. Note=Cellular distribution is dependent on the acetylation status of the multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization. Localizes in the nucleus during human herpes simplex virus 1 (HHV-1) infection. {ECO:0000269|PubMed:22691496}.; SUBCELLULAR LOCATION: [Isoform IFI16-beta]: Cytoplasm {ECO:0000269|PubMed:30104205}.
Q16667	reviewed	CDKN3_HUMAN	Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase)	CDKN3 CDI1 CIP2 KAP	Homo sapiens (Human)	212	FUNCTION: May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues (PubMed:8127873, PubMed:8242750). Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (PubMed:7569954). {ECO:0000269|PubMed:7569954, ECO:0000269|PubMed:8127873, ECO:0000269|PubMed:8242750}.		dephosphorylation [GO:0016311]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; dephosphorylation [GO:0016311]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10669749}.
Q16670	reviewed	ZSC26_HUMAN	Zinc finger and SCAN domain-containing protein 26 (Protein SRE-ZBP) (Zinc finger protein 187)	ZSCAN26 ZNF187	Homo sapiens (Human)	478	FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.		regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187, ECO:0000269|PubMed:1569959}.
Q16671	reviewed	AMHR2_HUMAN	Anti-Muellerian hormone type-2 receptor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII)	AMHR2 AMHR MISR2	Homo sapiens (Human)	573	FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.		anti-Mullerian hormone signaling pathway [GO:1990262]; blood vessel development [GO:0001568]; BMP signaling pathway [GO:0030509]; cellular response to growth factor stimulus [GO:0071363]; female gonad development [GO:0008585]; male gonad development [GO:0008584]; Mullerian duct regression [GO:0001880]; phosphorylation [GO:0016310]; sex differentiation [GO:0007548]; transforming growth factor beta receptor signaling pathway [GO:0007179]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]	anti-Mullerian hormone receptor activity [GO:1990272]; ATP binding [GO:0005524]; hormone binding [GO:0042562]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type II [GO:0005026]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; anti-Mullerian hormone receptor activity [GO:1990272]; ATP binding [GO:0005524]; hormone binding [GO:0042562]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type II [GO:0005026]; anti-Mullerian hormone signaling pathway [GO:1990262]; blood vessel development [GO:0001568]; BMP signaling pathway [GO:0030509]; cellular response to growth factor stimulus [GO:0071363]; female gonad development [GO:0008585]; male gonad development [GO:0008584]; Mullerian duct regression [GO:0001880]; phosphorylation [GO:0016310]; sex differentiation [GO:0007548]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q16674	reviewed	MIA_HUMAN	Melanoma-derived growth regulatory protein (Melanoma inhibitory activity protein)	MIA	Homo sapiens (Human)	131	FUNCTION: Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.		extracellular matrix organization [GO:0030198]	extracellular space [GO:0005615]	growth factor activity [GO:0008083]	extracellular space [GO:0005615]; growth factor activity [GO:0008083]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted.
Q16676	reviewed	FOXD1_HUMAN	Forkhead box protein D1 (Forkhead-related protein FKHL8) (Forkhead-related transcription factor 4) (FREAC-4)	FOXD1 FKHL8 FREAC4	Homo sapiens (Human)	465	FUNCTION: Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes (PubMed:27805902). {ECO:0000250|UniProtKB:Q61345, ECO:0000269|PubMed:27805902}.		anatomical structure morphogenesis [GO:0009653]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; dichotomous subdivision of terminal units involved in ureteric bud branching [GO:0060678]; luteinizing hormone secretion [GO:0032275]; metanephric capsule development [GO:0072213]; metanephric capsule specification [GO:0072267]; metanephric nephron development [GO:0072210]; negative regulation of DNA-templated transcription [GO:0045892]; nephrogenic mesenchyme development [GO:0072076]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of gene expression [GO:0010628]; positive regulation of kidney development [GO:0090184]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; anatomical structure morphogenesis [GO:0009653]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; dichotomous subdivision of terminal units involved in ureteric bud branching [GO:0060678]; luteinizing hormone secretion [GO:0032275]; metanephric capsule development [GO:0072213]; metanephric capsule specification [GO:0072267]; metanephric nephron development [GO:0072210]; negative regulation of DNA-templated transcription [GO:0045892]; nephrogenic mesenchyme development [GO:0072076]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of gene expression [GO:0010628]; positive regulation of kidney development [GO:0090184]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q16678	reviewed	CP1B1_HUMAN	Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)	CYP1B1	Homo sapiens (Human)	543	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:20972997, PubMed:11555828, PubMed:12865317, PubMed:10681376, PubMed:15258110). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:20972997, PubMed:11555828, PubMed:12865317, PubMed:10681376, PubMed:15258110). Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2. Displays a predominant hydroxylase activity toward E2 at the C-4 position (PubMed:11555828, PubMed:12865317). Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (PubMed:10426814). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376, PubMed:15258110). Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system (PubMed:20972997). Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (PubMed:21068195). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (PubMed:10426814). Plays an important role in retinal vascular development. Under hyperoxic O2 conditions, promotes retinal angiogenesis and capillary morphogenesis, likely by metabolizing the oxygenated products generated during the oxidative stress. Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression (By similarity). {ECO:0000250|UniProtKB:Q64429, ECO:0000269|PubMed:10426814, ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15258110, ECO:0000269|PubMed:20972997, ECO:0000269|PubMed:21068195}.		adrenal gland development [GO:0030325]; angiogenesis [GO:0001525]; arachidonic acid metabolic process [GO:0019369]; benzene-containing compound metabolic process [GO:0042537]; blood vessel endothelial cell migration [GO:0043534]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cellular response to cAMP [GO:0071320]; cellular response to cortisol stimulus [GO:0071387]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to organic cyclic compound [GO:0071407]; cellular response to progesterone stimulus [GO:0071393]; cellular response to tumor necrosis factor [GO:0071356]; collagen fibril organization [GO:0030199]; DNA modification [GO:0006304]; endothelial cell migration [GO:0043542]; endothelial cell-cell adhesion [GO:0071603]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; estrous cycle [GO:0044849]; ganglion development [GO:0061548]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; male gonad development [GO:0008584]; membrane lipid catabolic process [GO:0046466]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; nitric oxide biosynthetic process [GO:0006809]; omega-hydroxylase P450 pathway [GO:0097267]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of translation [GO:0045727]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to arsenic-containing substance [GO:0046685]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to follicle-stimulating hormone [GO:0032354]; response to indole-3-methanol [GO:0071680]; response to nutrient [GO:0007584]; response to toxic substance [GO:0009636]; retinal blood vessel morphogenesis [GO:0061304]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; sterol metabolic process [GO:0016125]; toxin metabolic process [GO:0009404]; trabecular meshwork development [GO:0002930]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]	aromatase activity [GO:0070330]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; aromatase activity [GO:0070330]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; adrenal gland development [GO:0030325]; angiogenesis [GO:0001525]; arachidonic acid metabolic process [GO:0019369]; benzene-containing compound metabolic process [GO:0042537]; blood vessel endothelial cell migration [GO:0043534]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cellular response to cAMP [GO:0071320]; cellular response to cortisol stimulus [GO:0071387]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to organic cyclic compound [GO:0071407]; cellular response to progesterone stimulus [GO:0071393]; cellular response to tumor necrosis factor [GO:0071356]; collagen fibril organization [GO:0030199]; DNA modification [GO:0006304]; endothelial cell migration [GO:0043542]; endothelial cell-cell adhesion [GO:0071603]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; estrous cycle [GO:0044849]; ganglion development [GO:0061548]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; male gonad development [GO:0008584]; membrane lipid catabolic process [GO:0046466]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; nitric oxide biosynthetic process [GO:0006809]; omega-hydroxylase P450 pathway [GO:0097267]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of translation [GO:0045727]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to arsenic-containing substance [GO:0046685]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to follicle-stimulating hormone [GO:0032354]; response to indole-3-methanol [GO:0071680]; response to nutrient [GO:0007584]; response to toxic substance [GO:0009636]; retinal blood vessel morphogenesis [GO:0061304]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; sterol metabolic process [GO:0016125]; toxin metabolic process [GO:0009404]; trabecular meshwork development [GO:0002930]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64429}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64429}. Microsome membrane {ECO:0000250|UniProtKB:Q64429}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64429}. Mitochondrion {ECO:0000250|UniProtKB:Q64429}. Note=Located primarily in endoplasmic reticulum. Upon treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), CYP1B1 is also targeted to mitochondria. {ECO:0000250|UniProtKB:Q64429}.
Q16690	reviewed	DUS5_HUMAN	Dual specificity protein phosphatase 5 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH3)	DUSP5 VH3	Homo sapiens (Human)	384	FUNCTION: Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1. {ECO:0000269|PubMed:7961985}.		dephosphorylation [GO:0016311]; endoderm formation [GO:0001706]; ERK1 and ERK2 cascade [GO:0070371]; MAPK cascade [GO:0000165]; negative regulation of MAPK cascade [GO:0043409]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]; dephosphorylation [GO:0016311]; endoderm formation [GO:0001706]; ERK1 and ERK2 cascade [GO:0070371]; MAPK cascade [GO:0000165]; negative regulation of MAPK cascade [GO:0043409]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q16695	reviewed	H31T_HUMAN	Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)	H3-4 H3FT HIST3H3	Homo sapiens (Human)	136	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		chromatin organization [GO:0006325]; nucleosome assembly [GO:0006334]	chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; chromatin organization [GO:0006325]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q16696	reviewed	CP2AD_HUMAN	Cytochrome P450 2A13 (EC 1.14.14.1) (CYPIIA13)	CYP2A13	Homo sapiens (Human)	494	FUNCTION: Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. {ECO:0000269|PubMed:18779312}.		aflatoxin metabolic process [GO:0046222]; coumarin metabolic process [GO:0009804]; epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; coumarin 7-hydroxylase activity [GO:0008389]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; coumarin 7-hydroxylase activity [GO:0008389]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; aflatoxin metabolic process [GO:0046222]; coumarin metabolic process [GO:0009804]; epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Q16698	reviewed	DECR_HUMAN	2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1)	DECR1 DECR SDR18C1	Homo sapiens (Human)	335	FUNCTION: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. {ECO:0000269|PubMed:15531764}.		fatty acid beta-oxidation [GO:0006635]; positive regulation of cold-induced thermogenesis [GO:0120162]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	2,4-dienoyl-CoA reductase (NADPH) activity [GO:0008670]; identical protein binding [GO:0042802]; NADPH binding [GO:0070402]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 2,4-dienoyl-CoA reductase (NADPH) activity [GO:0008670]; identical protein binding [GO:0042802]; NADPH binding [GO:0070402]; fatty acid beta-oxidation [GO:0006635]; positive regulation of cold-induced thermogenesis [GO:0120162]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:7818482}.
Q16706	reviewed	MA2A1_HUMAN	Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)	MAN2A1 MANA2	Homo sapiens (Human)	1144	FUNCTION: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. {ECO:0000250|UniProtKB:P28494}.		in utero embryonic development [GO:0001701]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; mannose metabolic process [GO:0006013]; mitochondrion organization [GO:0007005]; N-glycan processing [GO:0006491]; positive regulation of neurogenesis [GO:0050769]; respiratory gaseous exchange by respiratory system [GO:0007585]; retina morphogenesis in camera-type eye [GO:0060042]; vacuole organization [GO:0007033]; viral protein processing [GO:0019082]	cis-Golgi network [GO:0005801]; extracellular exosome [GO:0070062]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]	cis-Golgi network [GO:0005801]; extracellular exosome [GO:0070062]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; in utero embryonic development [GO:0001701]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; mannose metabolic process [GO:0006013]; mitochondrion organization [GO:0007005]; N-glycan processing [GO:0006491]; positive regulation of neurogenesis [GO:0050769]; respiratory gaseous exchange by respiratory system [GO:0007585]; retina morphogenesis in camera-type eye [GO:0060042]; vacuole organization [GO:0007033]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:P28494}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P28494}.
Q16718	reviewed	NDUA5_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (Complex I subunit B13) (Complex I-13kD-B) (CI-13kD-B) (NADH-ubiquinone oxidoreductase 13 kDa-B subunit)	NDUFA5	Homo sapiens (Human)	116	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory electron transport chain [GO:0022904]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory electron transport chain [GO:0022904]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Q16719	reviewed	KYNU_HUMAN	Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase)	KYNU	Homo sapiens (Human)	465	FUNCTION: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. {ECO:0000269|PubMed:11985583, ECO:0000269|PubMed:17300176, ECO:0000269|PubMed:28792876, ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}.		'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; L-kynurenine catabolic process [GO:0097053]; NAD biosynthetic process [GO:0009435]; quinolinate biosynthetic process [GO:0019805]; response to type II interferon [GO:0034341]; response to vitamin B6 [GO:0034516]; tryptophan catabolic process [GO:0006569]; tryptophan catabolic process to kynurenine [GO:0019441]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	3-hydroxykynureninase activity [GO:0061981]; kynureninase activity [GO:0030429]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; 3-hydroxykynureninase activity [GO:0061981]; kynureninase activity [GO:0030429]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; L-kynurenine catabolic process [GO:0097053]; NAD biosynthetic process [GO:0009435]; quinolinate biosynthetic process [GO:0019805]; response to type II interferon [GO:0034341]; response to vitamin B6 [GO:0034516]; tryptophan catabolic process [GO:0006569]; tryptophan catabolic process to kynurenine [GO:0019441]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000269|PubMed:8706755}.
Q16720	reviewed	AT2B3_HUMAN	Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3)	ATP2B3	Homo sapiens (Human)	1220	FUNCTION: ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals (PubMed:25953895, PubMed:27035656, PubMed:22912398, PubMed:18029012). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:25953895, PubMed:27035656). May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established (By similarity). {ECO:0000250|UniProtKB:Q64568, ECO:0000269|PubMed:18029012, ECO:0000269|PubMed:22912398, ECO:0000269|PubMed:25953895, ECO:0000269|PubMed:27035656}.		calcium ion export across plasma membrane [GO:1990034]; monoatomic ion transmembrane transport [GO:0034220]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]	extracellular vesicle [GO:1903561]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; parallel fiber [GO:1990032]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration [GO:1905056]; PDZ domain binding [GO:0030165]	extracellular vesicle [GO:1903561]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; parallel fiber [GO:1990032]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration [GO:1905056]; PDZ domain binding [GO:0030165]; calcium ion export across plasma membrane [GO:1990034]; monoatomic ion transmembrane transport [GO:0034220]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18029012, ECO:0000269|PubMed:25953895}; Multi-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q64568}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at parallel fiber terminals. {ECO:0000250|UniProtKB:Q64568}.
Q16739	reviewed	CEGT_HUMAN	Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (Glycosylceramide synthase) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase)	UGCG	Homo sapiens (Human)	394	FUNCTION: Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi (PubMed:8643456, PubMed:1532799). Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) (PubMed:1532799, PubMed:8643456). GlcCer is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (PubMed:8643456). Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction, implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions (By similarity). They are required for instance in the proper development and functioning of the nervous system (By similarity). As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway (By similarity). They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope (By similarity). The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity). Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor (PubMed:33361282). {ECO:0000250|UniProtKB:O88693, ECO:0000269|PubMed:1532799, ECO:0000269|PubMed:33361282, ECO:0000269|PubMed:8643456, ECO:0000303|PubMed:8643456}.		cell differentiation [GO:0030154]; cornified envelope assembly [GO:1903575]; epidermis development [GO:0008544]; establishment of skin barrier [GO:0061436]; glucosylceramide biosynthetic process [GO:0006679]; glycosphingolipid metabolic process [GO:0006687]; intestinal lipid absorption [GO:0098856]; keratinocyte differentiation [GO:0030216]; leptin-mediated signaling pathway [GO:0033210]; neuron development [GO:0048666]; protein lipidation [GO:0006497]; regulation of signal transduction [GO:0009966]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	ceramide glucosyltransferase activity [GO:0008120]; dihydroceramide glucosyltransferase activity [GO:0102769]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; ceramide glucosyltransferase activity [GO:0008120]; dihydroceramide glucosyltransferase activity [GO:0102769]; cell differentiation [GO:0030154]; cornified envelope assembly [GO:1903575]; epidermis development [GO:0008544]; establishment of skin barrier [GO:0061436]; glucosylceramide biosynthetic process [GO:0006679]; glycosphingolipid metabolic process [GO:0006687]; intestinal lipid absorption [GO:0098856]; keratinocyte differentiation [GO:0030216]; leptin-mediated signaling pathway [GO:0033210]; neuron development [GO:0048666]; protein lipidation [GO:0006497]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12873973}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9R0E0}.
Q16740	reviewed	CLPP_HUMAN	ATP-dependent Clp protease proteolytic subunit, mitochondrial (EC 3.4.21.92) (Endopeptidase Clp)	CLPP	Homo sapiens (Human)	277	FUNCTION: Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (PubMed:11923310, PubMed:15522782). Cleaves PINK1 in the mitochondrion (PubMed:22354088). {ECO:0000269|PubMed:11923310, ECO:0000269|PubMed:15522782, ECO:0000269|PubMed:22354088}.		membrane protein proteolysis [GO:0033619]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]	endopeptidase Clp complex [GO:0009368]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP-dependent peptidase activity [GO:0004176]; ATPase binding [GO:0051117]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	endopeptidase Clp complex [GO:0009368]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP-dependent peptidase activity [GO:0004176]; ATPase binding [GO:0051117]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; membrane protein proteolysis [GO:0033619]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:10525407, ECO:0000269|PubMed:22354088}.
Q16760	reviewed	DGKD_HUMAN	Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta)	DGKD KIAA0145	Homo sapiens (Human)	1214	FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250|UniProtKB:E9PUQ8, ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095, ECO:0000305}.		diacylglycerol metabolic process [GO:0046339]; endocytosis [GO:0006897]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of protein kinase C signaling [GO:0090038]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein transport [GO:0015031]; signal transduction [GO:0007165]	clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; diacylglycerol binding [GO:0019992]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; diacylglycerol binding [GO:0019992]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; diacylglycerol metabolic process [GO:0046339]; endocytosis [GO:0006897]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of protein kinase C signaling [GO:0090038]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein transport [GO:0015031]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000269|PubMed:17880279}. Cytoplasm {ECO:0000269|PubMed:12200442}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12200442}; Peripheral membrane protein {ECO:0000269|PubMed:12200442}. Cytoplasm {ECO:0000269|PubMed:12200442}. Note=Isoform 1 translocation from cytoplasm to the plasma membrane is induced by phorbol esters (PubMed:12200442). Phorbol esters induce the conversion into the monomeric form which can translocate to the plasma membrane (PubMed:12084710). {ECO:0000269|PubMed:12084710, ECO:0000269|PubMed:12200442}.
Q16762	reviewed	THTR_HUMAN	Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese)	TST	Homo sapiens (Human)	297	FUNCTION: Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA. {ECO:0000250, ECO:0000269|PubMed:20663881, ECO:0000269|PubMed:21685364}.		cyanate catabolic process [GO:0009440]; epithelial cell differentiation [GO:0030855]; rRNA import into mitochondrion [GO:0035928]; rRNA transport [GO:0051029]; sulfur amino acid catabolic process [GO:0000098]	extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	5S rRNA binding [GO:0008097]; thiosulfate sulfurtransferase activity [GO:0004792]	extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 5S rRNA binding [GO:0008097]; thiosulfate sulfurtransferase activity [GO:0004792]; cyanate catabolic process [GO:0009440]; epithelial cell differentiation [GO:0030855]; rRNA import into mitochondrion [GO:0035928]; rRNA transport [GO:0051029]; sulfur amino acid catabolic process [GO:0000098]	SUBCELLULAR LOCATION: Mitochondrion matrix.
Q16763	reviewed	UBE2S_HUMAN	Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S)	UBE2S E2EPF OK/SW-cl.73	Homo sapiens (Human)	222	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874). {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22496338, ECO:0000269|PubMed:27259151}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; exit from mitosis [GO:0010458]; free ubiquitin chain polymerization [GO:0010994]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein modification process [GO:0036211]; ubiquitin-dependent protein catabolic process [GO:0006511]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	anaphase-promoting complex binding [GO:0010997]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; anaphase-promoting complex binding [GO:0010997]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; exit from mitosis [GO:0010458]; free ubiquitin chain polymerization [GO:0010994]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein modification process [GO:0036211]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q16769	reviewed	QPCT_HUMAN	Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC)	QPCT	Homo sapiens (Human)	361	FUNCTION: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. {ECO:0000269|PubMed:15063747, ECO:0000269|PubMed:18486145, ECO:0000269|PubMed:21288892}.		peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase [GO:0017186]; protein modification process [GO:0036211]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	glutaminyl-peptide cyclotransferase activity [GO:0016603]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; glutaminyl-peptide cyclotransferase activity [GO:0016603]; zinc ion binding [GO:0008270]; peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase [GO:0017186]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18486145}.
Q16772	reviewed	GSTA3_HUMAN	Glutathione S-transferase A3 (EC 2.5.1.18) (GST class-alpha member 3) (Glutathione S-transferase A3-3)	GSTA3	Homo sapiens (Human)	222	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity). {ECO:0000250|UniProtKB:P30115, ECO:0000269|PubMed:11418619, ECO:0000269|PubMed:15595823, ECO:0000269|PubMed:20083122}.		glutathione metabolic process [GO:0006749]; lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	glutathione transferase activity [GO:0004364]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutathione transferase activity [GO:0004364]; glutathione metabolic process [GO:0006749]; lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm.
Q16773	reviewed	KAT1_HUMAN	Kynurenine--oxoglutarate transaminase 1 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase) (EC 4.4.1.13) (Glutamine transaminase K) (GTK) (Glutamine--phenylpyruvate transaminase) (EC 2.6.1.64) (Kynurenine aminotransferase 1) (Kynurenine aminotransferase I) (KATI) (Kynurenine--oxoglutarate transaminase I)	KYAT1 CCBL1	Homo sapiens (Human)	422	FUNCTION: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19338303, PubMed:28097769). Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites (PubMed:7883047). Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:7883047). {ECO:0000269|PubMed:19338303, ECO:0000269|PubMed:28097769, ECO:0000269|PubMed:7883047}.		biosynthetic process [GO:0009058]; kynurenine metabolic process [GO:0070189]; L-kynurenine catabolic process [GO:0097053]; response to bacterium [GO:0009617]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	cysteine-S-conjugate beta-lyase activity [GO:0047804]; glutamine-phenylpyruvate transaminase activity [GO:0047316]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; cysteine-S-conjugate beta-lyase activity [GO:0047804]; glutamine-phenylpyruvate transaminase activity [GO:0047316]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; biosynthetic process [GO:0009058]; kynurenine metabolic process [GO:0070189]; L-kynurenine catabolic process [GO:0097053]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:7883047}.
Q16774	reviewed	KGUA_HUMAN	Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Guanylate kinase 1)	GUK1 GMK GMPK	Homo sapiens (Human)	197	FUNCTION: Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664). {ECO:0000250|UniProtKB:P46195, ECO:0000269|PubMed:197968, ECO:0000269|PubMed:31201273, ECO:0000269|PubMed:6248551, ECO:0000269|PubMed:6306664}.		dGDP biosynthetic process [GO:0006185]; nucleobase-containing small molecule interconversion [GO:0015949]; phosphorylation [GO:0016310]; purine nucleotide metabolic process [GO:0006163]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; photoreceptor inner segment [GO:0001917]	ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385]	cytosol [GO:0005829]; photoreceptor inner segment [GO:0001917]; ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385]; dGDP biosynthetic process [GO:0006185]; nucleobase-containing small molecule interconversion [GO:0015949]; phosphorylation [GO:0016310]; purine nucleotide metabolic process [GO:0006163]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Photoreceptor inner segment {ECO:0000250|UniProtKB:Q64520}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q64520}. Note=Colocalizes with RD3 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer. {ECO:0000250|UniProtKB:Q64520}.
Q16775	reviewed	GLO2_HUMAN	Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)	HAGH GLO2 HAGH1	Homo sapiens (Human)	308	FUNCTION: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. {ECO:0000269|PubMed:8550579}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing. Also produced by alternative initiation at Met-49 of isoform 1. {ECO:0000305}.	glutathione biosynthetic process [GO:0006750]; glutathione metabolic process [GO:0006749]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872]; glutathione biosynthetic process [GO:0006750]; glutathione metabolic process [GO:0006749]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion matrix {ECO:0000269|PubMed:15117945}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15117945}.
Q16777	reviewed	H2A2C_HUMAN	Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)	H2AC20 H2AFQ HIST2H2AC	Homo sapiens (Human)	129	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.			extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q16778	reviewed	H2B2E_HUMAN	Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)	H2BC21 H2BFQ HIST2H2BE	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; nucleosome assembly [GO:0006334]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q16787	reviewed	LAMA3_HUMAN	Laminin subunit alpha-3 (Epiligrin 170 kDa subunit) (E170) (Epiligrin subunit alpha) (Kalinin subunit alpha) (Laminin-5 subunit alpha) (Laminin-6 subunit alpha) (Laminin-7 subunit alpha) (Nicein subunit alpha)	LAMA3 LAMNA	Homo sapiens (Human)	3333	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.; FUNCTION: Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.		cell-cell adhesion [GO:0098609]; endodermal cell differentiation [GO:0035987]; epidermis development [GO:0008544]; hemidesmosome assembly [GO:0031581]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]	adherens junction [GO:0005912]; basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; hemidesmosome [GO:0030056]; laminin-3 complex [GO:0005608]; laminin-5 complex [GO:0005610]	signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]	adherens junction [GO:0005912]; basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; hemidesmosome [GO:0030056]; laminin-3 complex [GO:0005608]; laminin-5 complex [GO:0005610]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; cell-cell adhesion [GO:0098609]; endodermal cell differentiation [GO:0035987]; epidermis development [GO:0008544]; hemidesmosome assembly [GO:0031581]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
Q16790	reviewed	CAH9_HUMAN	Carbonic anhydrase 9 (EC 4.2.1.1) (Carbonate dehydratase IX) (Carbonic anhydrase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC-associated antigen G250) (pMW1)	CA9 G250 MN	Homo sapiens (Human)	459	FUNCTION: Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). {ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18703501, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19805286}.		morphogenesis of an epithelium [GO:0002009]; one-carbon metabolic process [GO:0006730]; response to hypoxia [GO:0001666]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; secretion [GO:0046903]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	carbonate dehydratase activity [GO:0004089]; molecular function activator activity [GO:0140677]; zinc ion binding [GO:0008270]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; carbonate dehydratase activity [GO:0004089]; molecular function activator activity [GO:0140677]; zinc ion binding [GO:0008270]; morphogenesis of an epithelium [GO:0002009]; one-carbon metabolic process [GO:0006730]; response to hypoxia [GO:0001666]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; secretion [GO:0046903]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8486430}. Nucleus, nucleolus {ECO:0000269|PubMed:8486430}. Cell membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Cell projection, microvillus membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus.
Q16795	reviewed	NDUA9_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit)	NDUFA9 NDUFS2L	Homo sapiens (Human)	377	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Required for proper complex I assembly (PubMed:28671271). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:22114105, ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:28671271}.		aerobic respiration [GO:0009060]; circadian rhythm [GO:0007623]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; sodium ion transport [GO:0006814]; ubiquinone-6 biosynthetic process [GO:1901006]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]; NADH dehydrogenase activity [GO:0003954]; protein-containing complex binding [GO:0044877]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; NADH dehydrogenase activity [GO:0003954]; protein-containing complex binding [GO:0044877]; aerobic respiration [GO:0009060]; circadian rhythm [GO:0007623]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; sodium ion transport [GO:0006814]; ubiquinone-6 biosynthetic process [GO:1901006]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:12611891}.
Q16798	reviewed	MAON_HUMAN	NADP-dependent malic enzyme, mitochondrial (NADP-ME) (EC 1.1.1.40) (Malic enzyme 3)	ME3	Homo sapiens (Human)	604	FUNCTION: Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+) as a cofactor (PubMed:7818469). Can also reverse the decarboxylation reaction, but only with significantly lower efficiency (PubMed:7818469). {ECO:0000269|PubMed:7818469}.		aerobic respiration [GO:0009060]; malate metabolic process [GO:0006108]; oxygen metabolic process [GO:0072592]; pyruvate metabolic process [GO:0006090]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	malate dehydrogenase (decarboxylating) (NAD+) activity [GO:0004471]; malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; malic enzyme activity [GO:0004470]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADP+ binding [GO:0070401]; oxaloacetate decarboxylase activity [GO:0008948]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; malate dehydrogenase (decarboxylating) (NAD+) activity [GO:0004471]; malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; malic enzyme activity [GO:0004470]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADP+ binding [GO:0070401]; oxaloacetate decarboxylase activity [GO:0008948]; aerobic respiration [GO:0009060]; malate metabolic process [GO:0006108]; oxygen metabolic process [GO:0072592]; pyruvate metabolic process [GO:0006090]	SUBCELLULAR LOCATION: Mitochondrion matrix.
Q16799	reviewed	RTN1_HUMAN	Reticulon-1 (Neuroendocrine-specific protein)	RTN1 NSP	Homo sapiens (Human)	776	FUNCTION: Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}.		brain development [GO:0007420]; endoplasmic reticulum tubular network formation [GO:0071787]; negative regulation of amyloid-beta formation [GO:1902430]; neuron differentiation [GO:0030182]	dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]		dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; brain development [GO:0007420]; endoplasmic reticulum tubular network formation [GO:0071787]; negative regulation of amyloid-beta formation [GO:1902430]; neuron differentiation [GO:0030182]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12873973}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:12873973}; Multi-pass membrane protein {ECO:0000255}.
Q16816	reviewed	PHKG1_HUMAN	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26)	PHKG1 PHKG	Homo sapiens (Human)	387	FUNCTION: Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}.		carbohydrate metabolic process [GO:0005975]; glycogen biosynthetic process [GO:0005978]; phosphorylation [GO:0016310]	cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; phosphorylase kinase activity [GO:0004689]; protein serine kinase activity [GO:0106310]; tau-protein kinase activity [GO:0050321]	cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; phosphorylase kinase activity [GO:0004689]; protein serine kinase activity [GO:0106310]; tau-protein kinase activity [GO:0050321]; carbohydrate metabolic process [GO:0005975]; glycogen biosynthetic process [GO:0005978]; phosphorylation [GO:0016310]	
Q16819	reviewed	MEP1A_HUMAN	Meprin A subunit alpha (EC 3.4.24.18) (Endopeptidase-2) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha) (PABA peptide hydrolase) (PPH alpha)	MEP1A	Homo sapiens (Human)	746			epidermal growth factor receptor ligand maturation [GO:0038004]; signaling receptor ligand precursor processing [GO:0140448]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; meprin A complex [GO:0017090]; plasma membrane [GO:0005886]	metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; meprin A complex [GO:0017090]; plasma membrane [GO:0005886]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; epidermal growth factor receptor ligand maturation [GO:0038004]; signaling receptor ligand precursor processing [GO:0140448]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q16820	reviewed	MEP1B_HUMAN	Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABA peptide hydrolase) (PPH beta)	MEP1B	Homo sapiens (Human)	701	FUNCTION: Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. {ECO:0000269|PubMed:21693781}.		inflammatory response [GO:0006954]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; meprin A complex [GO:0017090]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; meprin A complex [GO:0017090]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; inflammatory response [GO:0006954]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22988105}; Single-pass type I membrane protein. Secreted {ECO:0000269|PubMed:10215852}. Note=Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17. {ECO:0000269|PubMed:22988105}.
Q16821	reviewed	PPR3A_HUMAN	Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit) (RG1)	PPP1R3A PP1G	Homo sapiens (Human)	1122	FUNCTION: Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	glycogen metabolic process [GO:0005977]; regulation of glycogen biosynthetic process [GO:0005979]	membrane [GO:0016020]; protein phosphatase type 1 complex [GO:0000164]	glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]	membrane [GO:0016020]; protein phosphatase type 1 complex [GO:0000164]; glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; glycogen metabolic process [GO:0005977]; regulation of glycogen biosynthetic process [GO:0005979]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q16822	reviewed	PCKGM_HUMAN	Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32)	PCK2 PEPCK2	Homo sapiens (Human)	640	FUNCTION: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. {ECO:0000250}.	MISCELLANEOUS: In eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one.	cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to tumor necrosis factor [GO:0071356]; gluconeogenesis [GO:0006094]; glycerol biosynthetic process from pyruvate [GO:0046327]; hepatocyte differentiation [GO:0070365]; NADH oxidation [GO:0006116]; oxaloacetate metabolic process [GO:0006107]; positive regulation of insulin secretion [GO:0032024]; propionate catabolic process [GO:0019543]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GTP binding [GO:0005525]; manganese ion binding [GO:0030145]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613]; phosphoenolpyruvate carboxykinase activity [GO:0004611]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; GTP binding [GO:0005525]; manganese ion binding [GO:0030145]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613]; phosphoenolpyruvate carboxykinase activity [GO:0004611]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to tumor necrosis factor [GO:0071356]; gluconeogenesis [GO:0006094]; glycerol biosynthetic process from pyruvate [GO:0046327]; hepatocyte differentiation [GO:0070365]; NADH oxidation [GO:0006116]; oxaloacetate metabolic process [GO:0006107]; positive regulation of insulin secretion [GO:0032024]; propionate catabolic process [GO:0019543]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594]	SUBCELLULAR LOCATION: Mitochondrion.
Q16825	reviewed	PTN21_HUMAN	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1)	PTPN21 PTPD1	Homo sapiens (Human)	1174			protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; protein tyrosine phosphatase activity [GO:0004725]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q16827	reviewed	PTPRO_HUMAN	Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2)	PTPRO GLEPP1 PTPU2	Homo sapiens (Human)	1216	FUNCTION: Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity). {ECO:0000250, ECO:0000269|PubMed:19167335}.	MISCELLANEOUS: [Isoform 3]: Predominantly expressed in B-lymphoid tissues. {ECO:0000305}.	axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; glomerulus development [GO:0032835]; lamellipodium assembly [GO:0030032]; monocyte chemotaxis [GO:0002548]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of glomerular filtration [GO:0003105]; negative regulation of neuron projection development [GO:0010977]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; peptidyl-tyrosine dephosphorylation [GO:0035335]; podocyte differentiation [GO:0072112]; protein dephosphorylation [GO:0006470]; regulation of glomerular filtration [GO:0003093]; regulation of synapse organization [GO:0050807]; slit diaphragm assembly [GO:0036060]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	cadherin binding [GO:0045296]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; Wnt-protein binding [GO:0017147]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; cadherin binding [GO:0045296]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; Wnt-protein binding [GO:0017147]; axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; glomerulus development [GO:0032835]; lamellipodium assembly [GO:0030032]; monocyte chemotaxis [GO:0002548]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of glomerular filtration [GO:0003105]; negative regulation of neuron projection development [GO:0010977]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; peptidyl-tyrosine dephosphorylation [GO:0035335]; podocyte differentiation [GO:0072112]; protein dephosphorylation [GO:0006470]; regulation of glomerular filtration [GO:0003093]; regulation of synapse organization [GO:0050807]; slit diaphragm assembly [GO:0036060]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q16828	reviewed	DUS6_HUMAN	Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)	DUSP6 MKP3 PYST1	Homo sapiens (Human)	381	FUNCTION: Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977). {ECO:0000250|UniProtKB:Q9DBB1, ECO:0000269|PubMed:29043977, ECO:0000269|PubMed:8670865}.		cell differentiation [GO:0030154]; ERK1 and ERK2 cascade [GO:0070371]; MAPK cascade [GO:0000165]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of apoptotic process [GO:0043065]; regulation of heart growth [GO:0060420]; response to growth factor [GO:0070848]; response to nitrosative stress [GO:0051409]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]; cell differentiation [GO:0030154]; ERK1 and ERK2 cascade [GO:0070371]; MAPK cascade [GO:0000165]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of apoptotic process [GO:0043065]; regulation of heart growth [GO:0060420]; response to growth factor [GO:0070848]; response to nitrosative stress [GO:0051409]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8670865}.
Q16829	reviewed	DUS7_HUMAN	Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2)	DUSP7 PYST2	Homo sapiens (Human)	419	FUNCTION: Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity). {ECO:0000250|UniProtKB:Q91Z46, ECO:0000269|PubMed:9788880}.		ERK1 and ERK2 cascade [GO:0070371]; MAPK cascade [GO:0000165]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; peptidyl-tyrosine dephosphorylation [GO:0035335]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]; ERK1 and ERK2 cascade [GO:0070371]; MAPK cascade [GO:0000165]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; peptidyl-tyrosine dephosphorylation [GO:0035335]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9788880}.
Q16831	reviewed	UPP1_HUMAN	Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3)	UPP1 UP	Homo sapiens (Human)	310	FUNCTION: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:7488099, ECO:0000305}.	MISCELLANEOUS: [Isoform 2]: Inactive. {ECO:0000305}.	cellular response to glucose starvation [GO:0042149]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dTMP catabolic process [GO:0046074]; dUMP catabolic process [GO:0046079]; nucleobase-containing compound metabolic process [GO:0006139]; UMP catabolic process [GO:0046050]; UMP salvage [GO:0044206]; uridine catabolic process [GO:0006218]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	deoxyuridine phosphorylase activity [GO:0047847]; identical protein binding [GO:0042802]; thymidine phosphorylase activity [GO:0009032]; uridine phosphorylase activity [GO:0004850]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; deoxyuridine phosphorylase activity [GO:0047847]; identical protein binding [GO:0042802]; thymidine phosphorylase activity [GO:0009032]; uridine phosphorylase activity [GO:0004850]; cellular response to glucose starvation [GO:0042149]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dTMP catabolic process [GO:0046074]; dUMP catabolic process [GO:0046079]; nucleobase-containing compound metabolic process [GO:0006139]; UMP catabolic process [GO:0046050]; UMP salvage [GO:0044206]; uridine catabolic process [GO:0006218]	
Q16832	reviewed	DDR2_HUMAN	Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)	DDR2 NTRKR3 TKT TYRO10	Homo sapiens (Human)	855	FUNCTION: Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. {ECO:0000269|PubMed:16186104, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20004161, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:20734453, ECO:0000269|PubMed:30449416, ECO:0000269|PubMed:9659899}.		biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte proliferation [GO:0035988]; collagen fibril organization [GO:0030199]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; endochondral bone growth [GO:0003416]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; ossification [GO:0001503]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell proliferation [GO:1904899]; positive regulation of neuron projection development [GO:0010976]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of wound healing [GO:0090303]; protein autophosphorylation [GO:0046777]; regulation of bone mineralization [GO:0030500]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of tissue remodeling [GO:0034103]; response to muscle stretch [GO:0035994]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; collagen binding [GO:0005518]; protein tyrosine kinase collagen receptor activity [GO:0038062]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; collagen binding [GO:0005518]; protein tyrosine kinase collagen receptor activity [GO:0038062]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte proliferation [GO:0035988]; collagen fibril organization [GO:0030199]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; endochondral bone growth [GO:0003416]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; ossification [GO:0001503]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell proliferation [GO:1904899]; positive regulation of neuron projection development [GO:0010976]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of wound healing [GO:0090303]; protein autophosphorylation [GO:0046777]; regulation of bone mineralization [GO:0030500]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of tissue remodeling [GO:0034103]; response to muscle stretch [GO:0035994]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}; Single-pass type I membrane protein {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}.
Q16836	reviewed	HCDH_HUMAN	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)	HADH HAD HAD1 HADHSC SCHAD	Homo sapiens (Human)	314	FUNCTION: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). {ECO:0000250|UniProtKB:Q61425, ECO:0000269|PubMed:10231530, ECO:0000269|PubMed:11489939, ECO:0000269|PubMed:16725361}.		fatty acid beta-oxidation [GO:0006635]; negative regulation of insulin secretion [GO:0046676]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of insulin secretion [GO:0050796]; response to activity [GO:0014823]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; transferase activity [GO:0016740]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; transferase activity [GO:0016740]; fatty acid beta-oxidation [GO:0006635]; negative regulation of insulin secretion [GO:0046676]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of insulin secretion [GO:0050796]; response to activity [GO:0014823]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:8687463}.
Q16842	reviewed	SIA4B_HUMAN	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (Alpha 2,3-ST 2) (Beta-galactoside alpha-2,3-sialyltransferase 2) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) (EC 2.4.3.2) (ST3Gal II) (ST3GalII) (ST3GalA.2) (Sialyltransferase 4B) (SIAT4-B)	ST3GAL2 SIAT4B	Homo sapiens (Human)	350	FUNCTION: A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8920913, PubMed:9266697, PubMed:25916169). Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (PubMed:12716912). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:9266697, PubMed:25916169). {ECO:0000250|UniProtKB:Q11204, ECO:0000269|PubMed:12716912, ECO:0000269|PubMed:25916169, ECO:0000269|PubMed:8920913, ECO:0000269|PubMed:9266697}.		ganglioside biosynthetic process via lactosylceramide [GO:0010706]; globoside biosynthetic process via lactosylceramide [GO:0010707]; glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101]; keratan sulfate biosynthetic process [GO:0018146]; lipid glycosylation [GO:0030259]; O-glycan processing [GO:0016266]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; protein sialylation [GO:1990743]; sialylation [GO:0097503]; viral protein processing [GO:0019082]	extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase [GO:0047288]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; protein homodimerization activity [GO:0042803]; sialyltransferase activity [GO:0008373]	extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase [GO:0047288]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; protein homodimerization activity [GO:0042803]; sialyltransferase activity [GO:0008373]; ganglioside biosynthetic process via lactosylceramide [GO:0010706]; globoside biosynthetic process via lactosylceramide [GO:0010707]; glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101]; keratan sulfate biosynthetic process [GO:0018146]; lipid glycosylation [GO:0030259]; O-glycan processing [GO:0016266]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; protein sialylation [GO:1990743]; sialylation [GO:0097503]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:25916169}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000250}. Note=Membrane-bound form distributed along the Golgi cisternae, mainly in proximal compartments (PubMed:25916169). Secreted into the body fluid. {ECO:0000250, ECO:0000269|PubMed:25916169}.
Q16849	reviewed	PTPRN_HUMAN	Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]	PTPRN ICA3 ICA512	Homo sapiens (Human)	979	FUNCTION: Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). {ECO:0000250|UniProtKB:Q60673, ECO:0000269|PubMed:24843546}.; FUNCTION: [ICA512-transmembrane fragment]: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2. {ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}.; FUNCTION: [ICA512-cleaved cytosolic fragment]: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (PubMed:15596545, PubMed:16622421, PubMed:18178618). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068). {ECO:0000269|PubMed:15596545, ECO:0000269|PubMed:16622421, ECO:0000269|PubMed:18178618, ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}.		dense core granule maturation [GO:1990502]; insulin secretion [GO:0030073]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; luteinization [GO:0001553]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; regulation of secretion [GO:0051046]; response to reactive oxygen species [GO:0000302]	axon terminus [GO:0043679]; endosome [GO:0005768]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658]	spectrin binding [GO:0030507]; transcription factor binding [GO:0008134]; ubiquitin-like protein ligase binding [GO:0044389]	axon terminus [GO:0043679]; endosome [GO:0005768]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658]; spectrin binding [GO:0030507]; transcription factor binding [GO:0008134]; ubiquitin-like protein ligase binding [GO:0044389]; dense core granule maturation [GO:1990502]; insulin secretion [GO:0030073]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; luteinization [GO:0001553]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; regulation of secretion [GO:0051046]; response to reactive oxygen species [GO:0000302]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q63259}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q63259}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:25561468}; Single-pass type I membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:Q63259}. Cell projection, axon {ECO:0000250|UniProtKB:Q63259}. Synapse {ECO:0000250|UniProtKB:Q63259}. Cell membrane {ECO:0000269|PubMed:10457160}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q63259}. Endosome {ECO:0000250|UniProtKB:Q63259}. Note=Detected on neuronal secretory vesicles, but not on synaptic vesicles. Colocalizes with insulin-containing secretory granules (PubMed:25561468). Primarily detected on secretory vesicle membranes. Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles via the Golgi apparatus membranes. {ECO:0000250|UniProtKB:Q63259, ECO:0000269|PubMed:25561468}.; SUBCELLULAR LOCATION: [ICA512-transmembrane fragment]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q63259}.; SUBCELLULAR LOCATION: [ICA512-cleaved cytosolic fragment]: Nucleus {ECO:0000269|PubMed:15596545}.
Q16850	reviewed	CP51A_HUMAN	Lanosterol 14-alpha demethylase (LDM) (EC 1.14.14.154) (CYPLI) (Cytochrome P450 51A1) (CYP51A1) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase)	CYP51A1 CYP51	Homo sapiens (Human)	509	FUNCTION: Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis (PubMed:8619637, PubMed:9559662, PubMed:20149798). Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis (PubMed:8619637, PubMed:9559662, PubMed:20149798). Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL (PubMed:9559662). {ECO:0000269|PubMed:20149798, ECO:0000269|PubMed:8619637, ECO:0000269|PubMed:9559662}.		cholesterol biosynthetic process [GO:0006695]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein secretion [GO:0050709]; steroid biosynthetic process [GO:0006694]; sterol metabolic process [GO:0016125]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; sterol 14-demethylase activity [GO:0008398]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; sterol 14-demethylase activity [GO:0008398]; cholesterol biosynthetic process [GO:0006695]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein secretion [GO:0050709]; steroid biosynthetic process [GO:0006694]; sterol metabolic process [GO:0016125]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64654}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:Q64654}; Single-pass membrane protein {ECO:0000255}.
Q16851	reviewed	UGPA_HUMAN	UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase)	UGP2 UGP1	Homo sapiens (Human)	508	FUNCTION: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390, ECO:0000269|PubMed:8631325}.		brain development [GO:0007420]; glucose 1-phosphate metabolic process [GO:0019255]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; UDP-glucose metabolic process [GO:0006011]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	glucose binding [GO:0005536]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pyrimidine ribonucleotide binding [GO:0032557]; UTP:glucose-1-phosphate uridylyltransferase activity [GO:0003983]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; glucose binding [GO:0005536]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pyrimidine ribonucleotide binding [GO:0032557]; UTP:glucose-1-phosphate uridylyltransferase activity [GO:0003983]; brain development [GO:0007420]; glucose 1-phosphate metabolic process [GO:0019255]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; UDP-glucose metabolic process [GO:0006011]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390}.
Q16853	reviewed	AOC3_HUMAN	Membrane primary amine oxidase (EC 1.4.3.21) (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1)	AOC3 VAP1	Homo sapiens (Human)	763	FUNCTION: Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076, ECO:0000269|PubMed:23349812, ECO:0000269|PubMed:9653080}.	MISCELLANEOUS: [Isoform 2]: Devoid of the semicarbazide-sensitive amine oxidase (SSAO) activity. {ECO:0000305}.	amine metabolic process [GO:0009308]; cell adhesion [GO:0007155]; inflammatory response [GO:0006954]; negative regulation of primary amine oxidase activity [GO:1902283]; response to antibiotic [GO:0046677]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; primary amine oxidase activity [GO:0008131]; protein heterodimerization activity [GO:0046982]; quinone binding [GO:0048038]; tryptamine:oxygen oxidoreductase (deaminating) activity [GO:0052593]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; primary amine oxidase activity [GO:0008131]; protein heterodimerization activity [GO:0046982]; quinone binding [GO:0048038]; tryptamine:oxygen oxidoreductase (deaminating) activity [GO:0052593]; amine metabolic process [GO:0009308]; cell adhesion [GO:0007155]; inflammatory response [GO:0006954]; negative regulation of primary amine oxidase activity [GO:1902283]; response to antibiotic [GO:0046677]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9653080}; Single-pass type II membrane protein {ECO:0000269|PubMed:9653080}.
Q16854	reviewed	DGUOK_HUMAN	Deoxyguanosine kinase, mitochondrial (EC 2.7.1.113) (Deoxyadenosine kinase, mitochondrial) (EC 2.7.1.76)	DGUOK DGK	Homo sapiens (Human)	277	FUNCTION: Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:8692979, PubMed:8706825, PubMed:11687801, PubMed:17073823, PubMed:23043144). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents. {ECO:0000250|UniProtKB:Q9QX60, ECO:0000269|PubMed:11687801, ECO:0000269|PubMed:17073823, ECO:0000269|PubMed:23043144, ECO:0000269|PubMed:8692979, ECO:0000269|PubMed:8706825}.		dAMP salvage [GO:0106383]; dGTP metabolic process [GO:0046070]; guanosine metabolic process [GO:0008617]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; negative regulation of neuron projection development [GO:0010977]; phosphorylation [GO:0016310]; purine deoxyribonucleoside metabolic process [GO:0046122]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	ATP binding [GO:0005524]; deoxyadenosine kinase activity [GO:0004136]; deoxyguanosine kinase activity [GO:0004138]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ATP binding [GO:0005524]; deoxyadenosine kinase activity [GO:0004136]; deoxyguanosine kinase activity [GO:0004138]; dAMP salvage [GO:0106383]; dGTP metabolic process [GO:0046070]; guanosine metabolic process [GO:0008617]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; negative regulation of neuron projection development [GO:0010977]; phosphorylation [GO:0016310]; purine deoxyribonucleoside metabolic process [GO:0046122]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9QX60}.
Q16864	reviewed	VATF_HUMAN	V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F)	ATP6V1F ATP6S14 VATF	Homo sapiens (Human)	119	FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). {ECO:0000250|UniProtKB:Q28029, ECO:0000269|PubMed:33065002}.		endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	ATPase-coupled ion transmembrane transporter activity [GO:0042625]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]; ATPase-coupled ion transmembrane transporter activity [GO:0042625]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P50408}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P50408}; Peripheral membrane protein {ECO:0000305}.
Q16873	reviewed	LTC4S_HUMAN	Leukotriene C4 synthase (LTC4 synthase) (EC 4.4.1.20) (Glutathione S-transferase LTC4) (EC 2.5.1.-) (Leukotriene-C(4) synthase) (Leukotriene-C4 synthase)	LTC4S	Homo sapiens (Human)	150	FUNCTION: Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:7937884, PubMed:27791009, PubMed:27365393, PubMed:9153254, PubMed:23409838). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009). {ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:27365393, ECO:0000269|PubMed:27791009, ECO:0000269|PubMed:7937884, ECO:0000269|PubMed:9153254}.		leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; long-chain fatty acid biosynthetic process [GO:0042759]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]	enzyme activator activity [GO:0008047]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464]; lipid binding [GO:0008289]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; enzyme activator activity [GO:0008047]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464]; lipid binding [GO:0008289]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; long-chain fatty acid biosynthetic process [GO:0042759]	SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000269|PubMed:12023288}; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12023288, ECO:0000269|PubMed:19233132}; Multi-pass membrane protein. Nucleus membrane {ECO:0000269|PubMed:19233132}; Multi-pass membrane protein.
Q16875	reviewed	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]	PFKFB3	Homo sapiens (Human)	520	FUNCTION: Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:10077634, ECO:0000269|PubMed:17499765, ECO:0000305|PubMed:16316985}.		fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; 6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]	
Q16877	reviewed	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]	PFKFB4	Homo sapiens (Human)	469	FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate.		fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]	cytosol [GO:0005829]	6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]	cytosol [GO:0005829]; 6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]	
Q16878	reviewed	CDO1_HUMAN	Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I)	CDO1	Homo sapiens (Human)	200	FUNCTION: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. {ECO:0000269|PubMed:17135237}.		cysteine metabolic process [GO:0006534]; inflammatory response [GO:0006954]; L-cysteine catabolic process [GO:0019448]; lactation [GO:0007595]; response to amino acid [GO:0043200]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to glucocorticoid [GO:0051384]; sulfur amino acid biosynthetic process [GO:0000097]; taurine biosynthetic process [GO:0042412]	cytosol [GO:0005829]	cysteine dioxygenase activity [GO:0017172]; ferrous iron binding [GO:0008198]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; cysteine dioxygenase activity [GO:0017172]; ferrous iron binding [GO:0008198]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270]; cysteine metabolic process [GO:0006534]; inflammatory response [GO:0006954]; L-cysteine catabolic process [GO:0019448]; lactation [GO:0007595]; response to amino acid [GO:0043200]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to glucocorticoid [GO:0051384]; sulfur amino acid biosynthetic process [GO:0000097]; taurine biosynthetic process [GO:0042412]	
Q16880	reviewed	CGT_HUMAN	2-hydroxyacylsphingosine 1-beta-galactosyltransferase (EC 2.4.1.47) (Ceramide UDP-galactosyltransferase) (Cerebroside synthase) (UDP-galactose-ceramide galactosyltransferase)	UGT8 CGT UGT4	Homo sapiens (Human)	541	FUNCTION: Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed:9125199). Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (By similarity). {ECO:0000250|UniProtKB:Q09426, ECO:0000269|PubMed:9125199}.		central nervous system development [GO:0007417]; cytoskeleton organization [GO:0007010]; galactosylceramide biosynthetic process [GO:0006682]; glycosphingolipid metabolic process [GO:0006687]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; peripheral nervous system development [GO:0007422]; protein localization to paranode region of axon [GO:0002175]; response to immobilization stress [GO:0035902]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity [GO:0003851]; N-acylsphingosine galactosyltransferase activity [GO:0047263]; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity [GO:0003851]; N-acylsphingosine galactosyltransferase activity [GO:0047263]; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489]; central nervous system development [GO:0007417]; cytoskeleton organization [GO:0007010]; galactosylceramide biosynthetic process [GO:0006682]; glycosphingolipid metabolic process [GO:0006687]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; peripheral nervous system development [GO:0007422]; protein localization to paranode region of axon [GO:0002175]; response to immobilization stress [GO:0035902]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q09426}.
Q16881	reviewed	TRXR1_HUMAN	Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1)	TXNRD1 GRIM12 KDRF	Homo sapiens (Human)	649	FUNCTION: Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437). {ECO:0000269|PubMed:10849437, ECO:0000269|PubMed:8577704, ECO:0000305|PubMed:17512005}.; FUNCTION: [Isoform 1]: Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. {ECO:0000269|PubMed:18042542, ECO:0000269|PubMed:8577704}.; FUNCTION: [Isoform 4]: Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2. {ECO:0000269|PubMed:15199063}.; FUNCTION: [Isoform 5]: Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063). Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665). {ECO:0000269|PubMed:15199063, ECO:0000269|PubMed:9774665}.	MISCELLANEOUS: The thioredoxin reductase active site is a redox-active disulfide bond. The selenocysteine residue is also essential for catalytic activity. {ECO:0000250|UniProtKB:O89049}.; MISCELLANEOUS: [Isoform 1]: Minor isoform. {ECO:0000269|PubMed:18042542}.; MISCELLANEOUS: [Isoform 5]: Major isoform. The N-terminus of the sequence is processed into a mature form that lacks residues Met-151 and Asn-152 at the N-terminus. {ECO:0000305}.	cell population proliferation [GO:0008283]; cell redox homeostasis [GO:0045454]; mesoderm formation [GO:0001707]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	FAD binding [GO:0071949]; identical protein binding [GO:0042802]; NADPH peroxidase activity [GO:0050137]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; FAD binding [GO:0071949]; identical protein binding [GO:0042802]; NADPH peroxidase activity [GO:0050137]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]; cell population proliferation [GO:0008283]; cell redox homeostasis [GO:0045454]; mesoderm formation [GO:0001707]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:18042542}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:15199063}. Nucleus {ECO:0000269|PubMed:15199063}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:15199063}.
Q16890	reviewed	TPD53_HUMAN	Tumor protein D53 (hD53) (Tumor protein D52-like 1)	TPD52L1	Homo sapiens (Human)	204			G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]	
Q16891	reviewed	MIC60_HUMAN	MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89)	IMMT HMP MIC60 MINOS2 PIG4 PIG52	Homo sapiens (Human)	758	FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180}.		cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion homeostasis [GO:0051560]; neuron cellular homeostasis [GO:0070050]	membrane [GO:0016020]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]	RNA binding [GO:0003723]	membrane [GO:0016020]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]; RNA binding [GO:0003723]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion homeostasis [GO:0051560]; neuron cellular homeostasis [GO:0070050]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:25764979, ECO:0000269|PubMed:25997101}; Single-pass membrane protein {ECO:0000255}. Mitochondrion {ECO:0000269|PubMed:25781180}.
Q17R60	reviewed	IMPG1_HUMAN	Interphotoreceptor matrix proteoglycan 1 (Interphotoreceptor matrix proteoglycan of 150 kDa) (IPM-150) (Sialoprotein associated with cones and rods)	IMPG1 IPM150 SPACR	Homo sapiens (Human)	797	FUNCTION: Chondroitin sulfate-, heparin- and hyaluronan-binding protein (By similarity). May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (PubMed:9813076). {ECO:0000250|UniProtKB:Q8JIR8, ECO:0000269|PubMed:9813076}.		extracellular matrix organization [GO:0030198]; visual perception [GO:0007601]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	chondroitin sulfate binding [GO:0035374]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hyaluronic acid binding [GO:0005540]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; chondroitin sulfate binding [GO:0035374]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hyaluronic acid binding [GO:0005540]; extracellular matrix organization [GO:0030198]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:29777959}. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix {ECO:0000269|PubMed:29777959, ECO:0000269|PubMed:9719680, ECO:0000269|PubMed:9813076}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8R1W8}.
Q17R89	reviewed	RHG44_HUMAN	Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2)	ARHGAP44 KIAA0672 RICH2	Homo sapiens (Human)	818	FUNCTION: GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). {ECO:0000250|UniProtKB:F1LQX4, ECO:0000250|UniProtKB:Q5SSM3, ECO:0000269|PubMed:11431473}.		exocytosis [GO:0006887]; modification of dendritic spine [GO:0098886]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of Rac protein signal transduction [GO:0035021]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0099152]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; leading edge membrane [GO:0031256]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; recycling endosome [GO:0055037]	GTPase activator activity [GO:0005096]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; leading edge membrane [GO:0031256]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; recycling endosome [GO:0055037]; GTPase activator activity [GO:0005096]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]; exocytosis [GO:0006887]; modification of dendritic spine [GO:0098886]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of Rac protein signal transduction [GO:0035021]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0099152]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q5SSM3}. Recycling endosome {ECO:0000250|UniProtKB:Q5SSM3}. Presynapse {ECO:0000250|UniProtKB:Q5SSM3}. Cell projection, dendrite {ECO:0000250|UniProtKB:F1LQX4}. Note=In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites (By similarity). Located in convoluted dendritic plasma membrane sections enriched in polymerized actin and myosin (patches) along dendrites where often emerge filopodia (By similarity). {ECO:0000250|UniProtKB:F1LQX4, ECO:0000250|UniProtKB:Q5SSM3}.
Q17R98	reviewed	ZN827_HUMAN	Zinc finger protein 827	ZNF827	Homo sapiens (Human)	1081	FUNCTION: As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}.		chromatin remodeling [GO:0006338]; establishment of protein localization to telomere [GO:0070200]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of shelterin complex assembly [GO:1904791]; positive regulation of transcription by RNA polymerase II [GO:0045944]; telomere maintenance [GO:0000723]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; NuRD complex binding [GO:0120325]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; NuRD complex binding [GO:0120325]; chromatin remodeling [GO:0006338]; establishment of protein localization to telomere [GO:0070200]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of shelterin complex assembly [GO:1904791]; positive regulation of transcription by RNA polymerase II [GO:0045944]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:25150861}. Chromosome, telomere {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:30045876}.
Q17RB8	reviewed	LONF1_HUMAN	LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191)	LONRF1 RNF191	Homo sapiens (Human)	773				cytosol [GO:0005829]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	
Q17RD7	reviewed	SYT16_HUMAN	Synaptotagmin-16 (Chr14Syt) (Synaptotagmin 14-like protein) (Synaptotagmin XIV-related protein)	SYT16 STREP14 SYT14L SYT14R	Homo sapiens (Human)	645	FUNCTION: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.				identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]	identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]	
Q17RS7	reviewed	GEN_HUMAN	Flap endonuclease GEN homolog 1 (EC 3.1.-.-)	GEN1	Homo sapiens (Human)	908	FUNCTION: Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation (PubMed:19020614, PubMed:26682650). Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction (PubMed:26578604). Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA (PubMed:28049850). Has also endonuclease activity on 5'-flap and replication fork (RF) DNA substrates (PubMed:26578604). {ECO:0000269|PubMed:19020614, ECO:0000269|PubMed:26578604, ECO:0000269|PubMed:26682650, ECO:0000269|PubMed:28049850}.		double-strand break repair via homologous recombination [GO:0000724]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of centrosome duplication [GO:0010824]; replication fork processing [GO:0031297]; resolution of mitotic recombination intermediates [GO:0071140]; resolution of recombination intermediates [GO:0071139]	centrosome [GO:0005813]; nucleoplasm [GO:0005654]	5'-flap endonuclease activity [GO:0017108]; crossover junction DNA endonuclease activity [GO:0008821]; four-way junction DNA binding [GO:0000400]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]	centrosome [GO:0005813]; nucleoplasm [GO:0005654]; 5'-flap endonuclease activity [GO:0017108]; crossover junction DNA endonuclease activity [GO:0008821]; four-way junction DNA binding [GO:0000400]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of centrosome duplication [GO:0010824]; replication fork processing [GO:0031297]; resolution of mitotic recombination intermediates [GO:0071140]; resolution of recombination intermediates [GO:0071139]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:26578604, ECO:0000305|PubMed:28049850}.
Q17RW2	reviewed	COOA1_HUMAN	Collagen alpha-1(XXIV) chain	COL24A1	Homo sapiens (Human)	1714	FUNCTION: May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development. {ECO:0000269|PubMed:12874293}.		extracellular matrix organization [GO:0030198]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Q17RY0	reviewed	CPEB4_HUMAN	Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4)	CPEB4 KIAA1673	Homo sapiens (Human)	729	FUNCTION: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). {ECO:0000250|UniProtKB:Q7TN98, ECO:0000269|PubMed:22138752, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195, ECO:0000269|PubMed:27857118}.		cellular response to amino acid stimulus [GO:0071230]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to glucose starvation [GO:0042149]; ionotropic glutamate receptor signaling pathway [GO:0035235]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of neuron apoptotic process [GO:0043524]; response to ischemia [GO:0002931]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; messenger ribonucleoprotein complex [GO:1990124]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; messenger ribonucleoprotein complex [GO:1990124]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synapse [GO:0045202]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; cellular response to amino acid stimulus [GO:0071230]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to glucose starvation [GO:0042149]; ionotropic glutamate receptor signaling pathway [GO:0035235]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of neuron apoptotic process [GO:0043524]; response to ischemia [GO:0002931]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7TN98}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TN98}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q7TN98}. Postsynaptic density {ECO:0000250|UniProtKB:Q7TN98}. Cell projection, axon {ECO:0000250|UniProtKB:Q7TN98}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q7TN98}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q7TN98}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TN98}.
Q18PE1	reviewed	DOK7_HUMAN	Protein Dok-7 (Downstream of tyrosine kinase 7)	DOK7 C4orf25	Homo sapiens (Human)	504	FUNCTION: Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. {ECO:0000269|PubMed:20603078}.		neuromuscular junction development [GO:0007528]; positive regulation of protein tyrosine kinase activity [GO:0061098]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202]	lipid binding [GO:0008289]; protein kinase binding [GO:0019901]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]; neuromuscular junction development [GO:0007528]; positive regulation of protein tyrosine kinase activity [GO:0061098]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Note=Accumulates at neuromuscular junctions. {ECO:0000250}.
Q19AV6	reviewed	ZSWM7_HUMAN	Zinc finger SWIM domain-containing protein 7 (SWIM domain-containing and Srs2-interacting protein 1 homolog) (SWIM-type zinc finger domain-containing protein 7)	ZSWIM7 SWS1	Homo sapiens (Human)	140	FUNCTION: Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Required for meiotic progression, hence for fertility (PubMed:32719396, PubMed:33713115, PubMed:34402903). {ECO:0000269|PubMed:16710300, ECO:0000269|PubMed:21965664, ECO:0000269|PubMed:32719396, ECO:0000269|PubMed:33713115, ECO:0000269|PubMed:34402903}.		double-strand break repair via homologous recombination [GO:0000724]; protein stabilization [GO:0050821]	nucleus [GO:0005634]; Shu complex [GO:0097196]	zinc ion binding [GO:0008270]	nucleus [GO:0005634]; Shu complex [GO:0097196]; zinc ion binding [GO:0008270]; double-strand break repair via homologous recombination [GO:0000724]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q19T08	reviewed	ECSCR_HUMAN	Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2)	ECSCR ECSM2	Homo sapiens (Human)	205	FUNCTION: Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. {ECO:0000269|PubMed:18556573, ECO:0000269|PubMed:19416853}.		angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; negative regulation of angiogenesis [GO:0016525]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of proteasomal protein catabolic process [GO:1901800]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; negative regulation of angiogenesis [GO:0016525]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of proteasomal protein catabolic process [GO:1901800]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Q1EHB4	reviewed	SC5AC_HUMAN	Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12)	SLC5A12 SMCT2	Homo sapiens (Human)	618	FUNCTION: Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter (PubMed:17692818). Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate (By similarity). May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). {ECO:0000250|UniProtKB:Q49B93, ECO:0000250|UniProtKB:Q7T384, ECO:0000269|PubMed:17692818}.		monoatomic ion transport [GO:0006811]; monocarboxylic acid transport [GO:0015718]; sodium ion transport [GO:0006814]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	lactate transmembrane transporter activity [GO:0015129]; monocarboxylate:sodium symporter activity [GO:0140161]; organic acid:sodium symporter activity [GO:0005343]; symporter activity [GO:0015293]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; lactate transmembrane transporter activity [GO:0015129]; monocarboxylate:sodium symporter activity [GO:0140161]; organic acid:sodium symporter activity [GO:0005343]; symporter activity [GO:0015293]; monoatomic ion transport [GO:0006811]; monocarboxylic acid transport [GO:0015718]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:17692818}; Multi-pass membrane protein {ECO:0000269|PubMed:17692818}. Note=Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells. {ECO:0000250|UniProtKB:Q49B93}.
Q1HG43	reviewed	DOXA1_HUMAN	Dual oxidase maturation factor 1 (Dual oxidase activator 1) (Numb-interacting protein)	DUOXA1 NIP NUMBIP	Homo sapiens (Human)	343	FUNCTION: May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1. {ECO:0000305|PubMed:16651268}.		hydrogen peroxide metabolic process [GO:0042743]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; positive regulation of neuron differentiation [GO:0045666]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of inflammatory response [GO:0050727]; regulation of thyroid hormone generation [GO:2000609]	cell leading edge [GO:0031252]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]	cell leading edge [GO:0031252]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; hydrogen peroxide metabolic process [GO:0042743]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; positive regulation of neuron differentiation [GO:0045666]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of inflammatory response [GO:0050727]; regulation of thyroid hormone generation [GO:2000609]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q1HG44	reviewed	DOXA2_HUMAN	Dual oxidase maturation factor 2 (Dual oxidase activator 2)	DUOXA2	Homo sapiens (Human)	320	FUNCTION: Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis. {ECO:0000269|PubMed:16651268}.		hydrogen peroxide metabolic process [GO:0042743]; positive regulation of cell motility [GO:2000147]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; protein localization [GO:0008104]; protein maturation [GO:0051604]; protein transport [GO:0015031]; regulation of inflammatory response [GO:0050727]; regulation of thyroid hormone generation [GO:2000609]	apical part of cell [GO:0045177]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]	apical part of cell [GO:0045177]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; hydrogen peroxide metabolic process [GO:0042743]; positive regulation of cell motility [GO:2000147]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; protein localization [GO:0008104]; protein maturation [GO:0051604]; protein transport [GO:0015031]; regulation of inflammatory response [GO:0050727]; regulation of thyroid hormone generation [GO:2000609]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16651268}; Multi-pass membrane protein {ECO:0000269|PubMed:16651268}.
Q1L5Z9	reviewed	LONF2_HUMAN	LON peptidase N-terminal domain and RING finger protein 2 (Neuroblastoma apoptosis-related protease) (RING finger protein 192)	LONRF2 RNF192	Homo sapiens (Human)	754				cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	
Q1MSJ5	reviewed	CSPP1_HUMAN	Centrosome and spindle pole-associated protein 1	CSPP1 CSPP	Homo sapiens (Human)	1256	FUNCTION: May play a role in cell-cycle-dependent microtubule organization. {ECO:0000269|PubMed:16826565}.		positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; spindle [GO:0005819]; spindle pole [GO:0000922]		centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; spindle [GO:0005819]; spindle pole [GO:0000922]; positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Associated with mitotic spindles.
Q1MX18	reviewed	INSC_HUMAN	Protein inscuteable homolog	INSC	Homo sapiens (Human)	579	FUNCTION: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity). {ECO:0000250|UniProtKB:Q3HNM7, ECO:0000305|PubMed:16458856}.		apical protein localization [GO:0045176]; asymmetric cell division [GO:0008356]; cell differentiation [GO:0030154]; establishment of mitotic spindle orientation [GO:0000132]; nervous system development [GO:0007399]; regulation of asymmetric cell division [GO:0009786]; regulation of protein stability [GO:0031647]	apical cortex [GO:0045179]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	cytoskeletal anchor activity [GO:0008093]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]	apical cortex [GO:0045179]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; cytoskeletal anchor activity [GO:0008093]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; apical protein localization [GO:0045176]; asymmetric cell division [GO:0008356]; cell differentiation [GO:0030154]; establishment of mitotic spindle orientation [GO:0000132]; nervous system development [GO:0007399]; regulation of asymmetric cell division [GO:0009786]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22074847}. Cytoplasm, cell cortex {ECO:0000269|PubMed:22074847}. Note=Uniformly distributed in the cytoplasm during interphase. During metaphase, detected in the cell cortex, adjacent to the mitotic spindle poles. {ECO:0000269|PubMed:22074847}.
Q1RMZ1	reviewed	SAMTR_HUMAN	S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-)	BMT2 C7orf60 SAMTOR	Homo sapiens (Human)	405	FUNCTION: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071, PubMed:35776786). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071, PubMed:35776786). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071, PubMed:35776786). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). {ECO:0000255|HAMAP-Rule:MF_03044, ECO:0000269|PubMed:29123071, ECO:0000269|PubMed:35776786}.		cellular response to amino acid starvation [GO:0034198]; cellular response to methionine [GO:0061431]; methylation [GO:0032259]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of TORC1 signaling [GO:1904263]; regulation of TORC1 signaling [GO:1903432]	cytosol [GO:0005829]	S-adenosyl-L-methionine binding [GO:1904047]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	cytosol [GO:0005829]; S-adenosyl-L-methionine binding [GO:1904047]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; cellular response to amino acid starvation [GO:0034198]; cellular response to methionine [GO:0061431]; methylation [GO:0032259]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of TORC1 signaling [GO:1904263]; regulation of TORC1 signaling [GO:1903432]	
Q1W6H9	reviewed	F110C_HUMAN	Protein FAM110C	FAM110C	Homo sapiens (Human)	321	FUNCTION: May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}.		positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of cell projection assembly [GO:0060491]	cell cortex [GO:0005938]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; spindle pole [GO:0000922]	alpha-tubulin binding [GO:0043014]	cell cortex [GO:0005938]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; spindle pole [GO:0000922]; alpha-tubulin binding [GO:0043014]; positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of cell projection assembly [GO:0060491]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}. Nucleus {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}. Note=Colocalizes with microtubules during interphase (PubMed:17499476). Detected at the mitotic spindle poles (PubMed:17499476). Colocalizes with AKT1 at the cell cortex (PubMed:19698782). {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}.
Q24JP5	reviewed	T132A_HUMAN	Transmembrane protein 132A (HSPA5-binding protein 1)	TMEM132A HSPA5BP1 KIAA1583	Homo sapiens (Human)	1023	FUNCTION: May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity). {ECO:0000250}.		negative regulation of protein catabolic process [GO:0042177]; positive regulation of Wnt protein secretion [GO:0061357]; positive regulation of Wnt signaling pathway [GO:0030177]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of Wnt protein secretion [GO:0061357]; positive regulation of Wnt signaling pathway [GO:0030177]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q27J81	reviewed	INF2_HUMAN	Inverted formin-2 (HBEBP2-binding protein C)	INF2 C14orf151 C14orf173	Homo sapiens (Human)	1249	FUNCTION: Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}.		actin filament polymerization [GO:0030041]; regulation of mitochondrial fission [GO:0090140]	actin filament [GO:0005884]; perinuclear region of cytoplasm [GO:0048471]	actin binding [GO:0003779]; small GTPase binding [GO:0031267]	actin filament [GO:0005884]; perinuclear region of cytoplasm [GO:0048471]; actin binding [GO:0003779]; small GTPase binding [GO:0031267]; actin filament polymerization [GO:0030041]; regulation of mitochondrial fission [GO:0090140]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:20023659}.
Q29980	reviewed	MICB_HUMAN	MHC class I polypeptide-related sequence B (MIC-B)	MICB PERB11.2	Homo sapiens (Human)	383	FUNCTION: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. {ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}.	MISCELLANEOUS: [Isoform 3]: A GC to AG nucleotide substitution in intron 1 generates a splice junction which gives rise to an additional exon between exons 1 and 2. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; gamma-delta T cell activation [GO:0046629]; immune response [GO:0006955]; immune response-activating cell surface receptor signaling pathway [GO:0002429]; killing of cells of another organism [GO:0031640]; negative regulation of defense response to virus by host [GO:0050689]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; response to retinoic acid [GO:0032526]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	natural killer cell lectin-like receptor binding [GO:0046703]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; natural killer cell lectin-like receptor binding [GO:0046703]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]; adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; gamma-delta T cell activation [GO:0046629]; immune response [GO:0006955]; immune response-activating cell surface receptor signaling pathway [GO:0002429]; killing of cells of another organism [GO:0031640]; negative regulation of defense response to virus by host [GO:0050689]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; response to retinoic acid [GO:0032526]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q29983}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q29983}. Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q29983, ECO:0000269|PubMed:12782710}.
Q29983	reviewed	MICA_HUMAN	MHC class I polypeptide-related sequence A (MIC-A)	MICA PERB11.1	Homo sapiens (Human)	383	FUNCTION: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}.	MISCELLANEOUS: Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection. {ECO:0000269|PubMed:11053635}.; MISCELLANEOUS: [Isoform 2]: Found in about 10% of examined clones. {ECO:0000305}.	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; gamma-delta T cell activation [GO:0046629]; immune response [GO:0006955]; immune response to tumor cell [GO:0002418]; killing of cells of another organism [GO:0031640]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; response to heat [GO:0009408]; T cell mediated cytotoxicity [GO:0001913]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	natural killer cell lectin-like receptor binding [GO:0046703]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; natural killer cell lectin-like receptor binding [GO:0046703]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; gamma-delta T cell activation [GO:0046629]; immune response [GO:0006955]; immune response to tumor cell [GO:0002418]; killing of cells of another organism [GO:0031640]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; response to heat [GO:0009408]; T cell mediated cytotoxicity [GO:0001913]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}; Single-pass type I membrane protein {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}. Cytoplasm {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}. Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}.
Q29RF7	reviewed	PDS5A_HUMAN	Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112)	PDS5A KIAA0648 PDS5 PIG54	Homo sapiens (Human)	1337	FUNCTION: Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}.	MISCELLANEOUS: HeLa cells with a reduced level of PDS5A show a mild defect in sister chromatid cohesion. HeLa cells with a reduced level of RAD21 show reduced association of PDS5A with chromatin. {ECO:0000269|PubMed:15855230}.	cell division [GO:0051301]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of DNA replication [GO:0008156]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cell division [GO:0051301]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of DNA replication [GO:0008156]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:15019998}. Note=Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:15019998}.
Q2HXU8	reviewed	CL12B_HUMAN	C-type lectin domain family 12 member B (Macrophage antigen H)	CLEC12B UNQ5782/PRO16089	Homo sapiens (Human)	276	FUNCTION: Inhibitory receptor postulated to negatively regulate immune and non-immune functions (PubMed:17562706, PubMed:34310951). Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activation signals (PubMed:17562706, PubMed:34310951). Although it inhibits KLRK1/NKG2D-mediated signaling, it does not bind known ligands of KLRK1/NKG2D and therefore is not its inhibitory counterpart (PubMed:17562706). May limit activation of myeloid cell subsets in response to infection or tissue inflammation (PubMed:17562706). May protect target cells against natural killer cell-mediated lysis (PubMed:17562706). May negatively regulate cell cycle and differentiation of melanocytes via inactivation of STAT3 (PubMed:34310951). {ECO:0000269|PubMed:17562706, ECO:0000269|PubMed:34310951}.		melanocyte proliferation [GO:0097325]; natural killer cell inhibitory signaling pathway [GO:0002769]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; negative regulation of signaling receptor activity [GO:2000272]	external side of plasma membrane [GO:0009897]; protein-containing complex [GO:0032991]	carbohydrate binding [GO:0030246]; protein phosphatase binding [GO:0019903]; signaling receptor inhibitor activity [GO:0030547]	external side of plasma membrane [GO:0009897]; protein-containing complex [GO:0032991]; carbohydrate binding [GO:0030246]; protein phosphatase binding [GO:0019903]; signaling receptor inhibitor activity [GO:0030547]; melanocyte proliferation [GO:0097325]; natural killer cell inhibitory signaling pathway [GO:0002769]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; negative regulation of signaling receptor activity [GO:2000272]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17562706}; Single-pass type II membrane protein {ECO:0000255}.
Q2I0M4	reviewed	LRC26_HUMAN	Leucine-rich repeat-containing protein 26 (BK channel auxiliary gamma subunit LRRC26) (Cytokeratin-associated protein in cancer)	LRRC26 CAPC	Homo sapiens (Human)	334	FUNCTION: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium. {ECO:0000269|PubMed:20613726, ECO:0000269|PubMed:22547800}.	MISCELLANEOUS: [Isoform 2]: Translation initiates from a UGC codon. It is unsure whether the initiator amino acid is a modified cysteine or a methionine. Could also be the result of a proteolytic cleavage from a longer precursor. {ECO:0000305}.	positive regulation of voltage-gated potassium channel activity [GO:1903818]; potassium ion transmembrane transport [GO:0071805]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	potassium channel activator activity [GO:0099104]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; potassium channel activator activity [GO:0099104]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; positive regulation of voltage-gated potassium channel activity [GO:1903818]; potassium ion transmembrane transport [GO:0071805]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels. {ECO:0000269|PubMed:15164053}.
Q2I0M5	reviewed	RSPO4_HUMAN	R-spondin-4 (Roof plate-specific spondin-4) (hRspo4)	RSPO4 C20orf182	Homo sapiens (Human)	234	FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076). {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:29769720}.		nail development [GO:0035878]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt signaling pathway [GO:0016055]	extracellular region [GO:0005576]	heparin binding [GO:0008201]	extracellular region [GO:0005576]; heparin binding [GO:0008201]; nail development [GO:0035878]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q2KHM9	reviewed	MOONR_HUMAN	Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein)	KIAA0753 MNR OFIP	Homo sapiens (Human)	967	FUNCTION: Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}.		centriole replication [GO:0007099]; cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; protein localization to centrosome [GO:0071539]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]	2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; centriole replication [GO:0007099]; cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; protein localization to centrosome [GO:0071539]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26643951}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26643951}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26643951}. Note=Localization to centrioles and pericentriolar satellites may be mediated by interaction with PCM1. {ECO:0000269|PubMed:26643951}.
Q2KHN1	reviewed	RN151_HUMAN	RING finger protein 151	RNF151	Homo sapiens (Human)	245	FUNCTION: May be involved in acrosome formation of spermatids.		cell differentiation [GO:0030154]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q2KHR2	reviewed	RFX7_HUMAN	DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2)	RFX7 RFXDC2	Homo sapiens (Human)	1363			regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858}.
Q2KHT3	reviewed	CL16A_HUMAN	Protein CLEC16A (C-type lectin domain family 16 member A)	CLEC16A KIAA0350	Homo sapiens (Human)	1053	FUNCTION: Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. {ECO:0000269|PubMed:24949970}.		autophagy [GO:0006914]; cellular response to starvation [GO:0009267]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; negative regulation of autophagosome maturation [GO:1901097]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagosome maturation [GO:1901096]	cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; Golgi apparatus [GO:0005794]; vesicle [GO:0031982]		cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; Golgi apparatus [GO:0005794]; vesicle [GO:0031982]; autophagy [GO:0006914]; cellular response to starvation [GO:0009267]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; negative regulation of autophagosome maturation [GO:1901097]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagosome maturation [GO:1901096]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q80U30}. Lysosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q80U30}. Note=Associates with the endolysosome membrane. {ECO:0000250|UniProtKB:Q80U30}.
Q2KHT4	reviewed	GSG1_HUMAN	Germ cell-specific gene 1 protein	GSG1 UNQ709/PRO1360	Homo sapiens (Human)	349	FUNCTION: May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum. {ECO:0000250}.			endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]		endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with PAPOLB in the endoplasmic reticulum. {ECO:0000250}.
Q2LD37	reviewed	BLTP1_HUMAN	Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein)	BLTP1 FSA KIAA1109 KIAA1371 TWEEK	Homo sapiens (Human)	5005	FUNCTION: Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}.	MISCELLANEOUS: KIAA1109 is mapped in the genomic region associated with susceptibility to celiac disease (CELIAC6).	endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; intermembrane lipid transfer [GO:0120009]; phagocytosis [GO:0006909]; regulation of cell growth [GO:0001558]; regulation of epithelial cell differentiation [GO:0030856]; synaptic vesicle endocytosis [GO:0048488]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	phosphatidylethanolamine transfer activity [GO:1904121]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; phosphatidylethanolamine transfer activity [GO:1904121]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; intermembrane lipid transfer [GO:0120009]; phagocytosis [GO:0006909]; regulation of cell growth [GO:0001558]; regulation of epithelial cell differentiation [GO:0030856]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q12150}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q12150}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q12150}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to endoplasmic reticulum-cell membrane and some endoplasmic reticulum-mitochondria contact sites. {ECO:0000250|UniProtKB:Q12150}.
Q2M1K9	reviewed	ZN423_HUMAN	Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein)	ZNF423 KIAA0760 NPHP14 OAZ	Homo sapiens (Human)	1284	FUNCTION: Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. {ECO:0000269|PubMed:10660046}.		cell differentiation [GO:0030154]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of DNA-templated transcription [GO:0045893]; protein localization to cilium [GO:0061512]; regulation of DNA-templated transcription [GO:0006355]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; cell differentiation [GO:0030154]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of DNA-templated transcription [GO:0045893]; protein localization to cilium [GO:0061512]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10660046}.
Q2M1P5	reviewed	KIF7_HUMAN	Kinesin-like protein KIF7	KIF7 UNQ340/PRO539	Homo sapiens (Human)	1343	FUNCTION: Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}.		microtubule-based movement [GO:0007018]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of smoothened signaling pathway [GO:0045880]	ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of smoothened signaling pathway [GO:0045880]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:19592253}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:B7ZNG0}. Note=Localizes to the cilium tip.
Q2M1Z3	reviewed	RHG31_HUMAN	Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein)	ARHGAP31 CDGAP KIAA1204	Homo sapiens (Human)	1444	FUNCTION: Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}.		regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]	GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cell projection, lamellipodium. Cell junction, focal adhesion {ECO:0000250}.
Q2M2E3	reviewed	ODFP4_HUMAN	Outer dense fiber protein 4 (Outer dense fiber of sperm tails protein 4) (Testis-specific protein oppo 1) (hOPPO1)	ODF4 OPPO1	Homo sapiens (Human)	257	FUNCTION: Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q2M2I5	reviewed	K1C24_HUMAN	Keratin, type I cytoskeletal 24 (Cytokeratin-24) (CK-24) (Keratin-24) (K24) (Type I keratin-24)	KRT24 KA24	Homo sapiens (Human)	525		MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
Q2M2I8	reviewed	AAK1_HUMAN	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)	AAK1 KIAA1048	Homo sapiens (Human)	961	FUNCTION: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:17494869, PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}.		membrane organization [GO:0061024]; positive regulation of Notch signaling pathway [GO:0045747]; presynaptic endocytosis [GO:0140238]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of clathrin-dependent endocytosis [GO:2000369]; regulation of protein localization [GO:0032880]	cell leading edge [GO:0031252]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; terminal bouton [GO:0043195]	AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; Notch binding [GO:0005112]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell leading edge [GO:0031252]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; terminal bouton [GO:0043195]; AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; Notch binding [GO:0005112]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; membrane organization [GO:0061024]; positive regulation of Notch signaling pathway [GO:0045747]; presynaptic endocytosis [GO:0140238]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of clathrin-dependent endocytosis [GO:2000369]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:F1MH24}; Peripheral membrane protein {ECO:0000250|UniProtKB:F1MH24}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:11877461}. Presynapse {ECO:0000250|UniProtKB:P0C1X8}. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells. {ECO:0000250|UniProtKB:P0C1X8}.
Q2M2Z5	reviewed	KIZ_HUMAN	Centrosomal protein kizuna (Polo-like kinase 1 substrate 1)	KIZ C20orf19 NCRNA00153 PLK1S1 HT013	Homo sapiens (Human)	673	FUNCTION: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}.	MISCELLANEOUS: Kizuna means 'bonds' in Japanese.	spindle organization [GO:0007051]	cell projection [GO:0042995]; centrosome [GO:0005813]; cytoplasm [GO:0005737]	protein kinase binding [GO:0019901]	cell projection [GO:0042995]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; protein kinase binding [GO:0019901]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16980960}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24680887}. Note=Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome-surrounding area in a microtubule-independent and dependent manner, respectively. {ECO:0000269|PubMed:24680887}.
Q2M385	reviewed	MPEG1_HUMAN	Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2) [Cleaved into: Macrophage-expressed gene 1 protein, processed form]	MPEG1	Homo sapiens (Human)	716	FUNCTION: Pore-forming protein involved in both innate and adaptive immunity (PubMed:23753625, PubMed:26402460, PubMed:28422754, PubMed:30609079, PubMed:31537793, PubMed:33224153). Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation (By similarity). Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (PubMed:23753625, PubMed:26402460, PubMed:28422754, PubMed:30609079, PubMed:33224153). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity). {ECO:0000250|UniProtKB:A1L314, ECO:0000269|PubMed:23753625, ECO:0000269|PubMed:26402460, ECO:0000269|PubMed:28422754, ECO:0000269|PubMed:30609079, ECO:0000269|PubMed:31537793, ECO:0000269|PubMed:33224153}.; FUNCTION: [Macrophage-expressed gene 1 protein, processed form]: Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation (By similarity). Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8(+) T-cells (By similarity). Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming (By similarity). {ECO:0000250|UniProtKB:A1L314}.	MISCELLANEOUS: [Isoform 2]: Lacks the C-terminal transmembrane domain. {ECO:0000269|PubMed:28705375}.	antibacterial innate immune response [GO:0140367]; antigen processing and presentation of exogenous peptide antigen [GO:0002478]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; dendritic cell antigen processing and presentation [GO:0002468]	cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]	wide pore channel activity [GO:0022829]	cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; wide pore channel activity [GO:0022829]; antibacterial innate immune response [GO:0140367]; antigen processing and presentation of exogenous peptide antigen [GO:0002478]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; dendritic cell antigen processing and presentation [GO:0002468]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:28705375, ECO:0000269|PubMed:31537793}; Multi-pass membrane protein {ECO:0000255}. Note=Bacterial infection induces translocation of the cytoplasmic vesicles to bacterium-containing phagocytic vesicles and fusing of the vesicles. {ECO:0000269|PubMed:28705375}.; SUBCELLULAR LOCATION: [Macrophage-expressed gene 1 protein, processed form]: Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:A1L314}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A1L314}. Note=Proteolytically processed in lysosomes, leading to its maturation and forms pores in the membrane of antigen-containing phagosomes. {ECO:0000250|UniProtKB:A1L314}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:28705375}.
Q2M389	reviewed	WASC4_HUMAN	WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP)	WASHC4 KIAA1033	Homo sapiens (Human)	1173	FUNCTION: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000303|PubMed:21498477}.		endosomal transport [GO:0016197]; endosome organization [GO:0007032]; nuclear envelope budding [GO:0140591]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]	early endosome membrane [GO:0031901]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203]		early endosome membrane [GO:0031901]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; nuclear envelope budding [GO:0140591]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:23676666}.
Q2M3C6	reviewed	TM266_HUMAN	Transmembrane protein 266 (hTMEM266) (HV1-related protein 1) (HsHVRP1)	TMEM266 C15orf27 HVRP1	Homo sapiens (Human)	531	FUNCTION: Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (PubMed:25165868, PubMed:30810529). Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear (PubMed:25165868, PubMed:30810529). Undergoes both rapid and slow structural rearrangements in response to changes in voltage (PubMed:30810529). Contains a zinc-binding site that can regulate the slow conformational transition (PubMed:30810529). {ECO:0000269|PubMed:25165868, ECO:0000269|PubMed:30810529}.			cytosol [GO:0005829]; dendrite [GO:0030425]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]	protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; dendrite [GO:0030425]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22020278, ECO:0000269|PubMed:25165868}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:25165868}. Perikaryon {ECO:0000269|PubMed:25165868}. Note=Present in the dendrites and soma of cerebellar granule neurons, but not in their axon. {ECO:0000269|PubMed:25165868}.
Q2M3C7	reviewed	SPKAP_HUMAN	A-kinase anchor protein SPHKAP (SPHK1-interactor and AKAP domain-containing protein) (Sphingosine kinase type 1-interacting protein)	SPHKAP KIAA1678 SKIP	Homo sapiens (Human)	1700	FUNCTION: Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}.			cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	protein kinase A binding [GO:0051018]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; protein kinase A binding [GO:0051018]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}. Note=Colocalizes with SPHK1 in the cytoplasm.
Q2M3G0	reviewed	ABCB5_HUMAN	ATP-binding cassette sub-family B member 5 (ABCB5 P-gp) (P-glycoprotein ABCB5) (EC 7.6.2.2)	ABCB5	Homo sapiens (Human)	1257	FUNCTION: Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:22306008, PubMed:15899824, PubMed:15205344). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity). {ECO:0000250|UniProtKB:B5X0E4, ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15205344, ECO:0000269|PubMed:15899824, ECO:0000269|PubMed:22306008}.	MISCELLANEOUS: Acts as a marker of stem-like cells (CSC) in a number of malignancies (PubMed:24934811). Associated with clinical drug resistance, tumor progression and disease recurrence in malignant melanoma and acute leukemias. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. ABCB5-expressing cells selectively survive when exposed to dacarbazine drug, the reference treatment of metastatic melanoma, vemurafenib and other various chemotherapeutic drugs, suggesting that anti-melanoma chemotherapy participates in the chemoresistance acquisition by selecting tumor cell subpopulations expressing ABCB5 (PubMed:22784549, PubMed:22044138, PubMed:22675422, PubMed:23770371, PubMed:24934811). Present in melanoma-initiating cells that acts as an enhancer of tumor growth by promoting CSC maintenance and tumor growth by controlling IL-1beta (IL1B) secretion to maintain slow-cycling, chemoresistant cells through an IL-1beta (IL1B)/IL8/CXCR1 cytokine signaling circuit (PubMed:24934811). {ECO:0000305|PubMed:22044138, ECO:0000305|PubMed:22675422, ECO:0000305|PubMed:22784549, ECO:0000305|PubMed:23770371, ECO:0000305|PubMed:24934811}.	cell differentiation [GO:0030154]; eye development [GO:0001654]; regulation of membrane potential [GO:0042391]; transmembrane transport [GO:0055085]	plasma membrane [GO:0005886]	ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; efflux transmembrane transporter activity [GO:0015562]	plasma membrane [GO:0005886]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; efflux transmembrane transporter activity [GO:0015562]; cell differentiation [GO:0030154]; eye development [GO:0001654]; regulation of membrane potential [GO:0042391]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12960149}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12960149}.
Q2M3M2	reviewed	SC5A9_HUMAN	Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (hSGLT4) (Solute carrier family 5 member 9)	SLC5A9 SGLT4	Homo sapiens (Human)	681	FUNCTION: Electrogenic Na(+)-coupled sugar symporter that may play a primary role in D-mannose and possibly D-fructose and D-glucose transport at the plasma membrane. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2. {ECO:0000269|PubMed:15607332, ECO:0000305|PubMed:35077764}.		hexose transmembrane transport [GO:0008645]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	glucose:sodium symporter activity [GO:0005412]; low-affinity glucose:sodium symporter activity [GO:0005362]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; glucose:sodium symporter activity [GO:0005412]; low-affinity glucose:sodium symporter activity [GO:0005362]; hexose transmembrane transport [GO:0008645]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:15607332}; Multi-pass membrane protein {ECO:0000255}.
Q2M3R5	reviewed	S35G1_HUMAN	Solute carrier family 35 member G1 (Partner of STIM1) (Transmembrane protein 20)	SLC35G1 C10orf60 POST TMEM20	Homo sapiens (Human)	365	FUNCTION: May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell. {ECO:0000269|PubMed:22084111}.		calcium ion export across plasma membrane [GO:1990034]; regulation of cytosolic calcium ion concentration [GO:0051480]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]		endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; calcium ion export across plasma membrane [GO:1990034]; regulation of cytosolic calcium ion concentration [GO:0051480]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22084111}; Multi-pass membrane protein {ECO:0000269|PubMed:22084111}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22084111}; Multi-pass membrane protein {ECO:0000269|PubMed:22084111}. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane.
Q2M3T9	reviewed	HYAL4_HUMAN	Hyaluronidase-4 (Hyal-4) (EC 3.2.1.35) (Chondroitin sulfate endo-beta-N-acetylgalactosaminidase) (Chondroitin sulfate hydrolase) (CSHY) (Hyaluronoglucosaminidase-4)	HYAL4	Homo sapiens (Human)	481	FUNCTION: Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide. {ECO:0000269|PubMed:16104017, ECO:0000269|PubMed:19889881}.		carbohydrate metabolic process [GO:0005975]; chondroitin sulfate catabolic process [GO:0030207]; glycosaminoglycan catabolic process [GO:0006027]; hyaluronan catabolic process [GO:0030214]	cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]	hyalurononglucosaminidase activity [GO:0004415]	cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; hyalurononglucosaminidase activity [GO:0004415]; carbohydrate metabolic process [GO:0005975]; chondroitin sulfate catabolic process [GO:0030207]; glycosaminoglycan catabolic process [GO:0006027]; hyaluronan catabolic process [GO:0030214]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q2MKA7	reviewed	RSPO1_HUMAN	R-spondin-1 (Roof plate-specific spondin-1) (hRspo1)	RSPO1	Homo sapiens (Human)	263	FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805). {ECO:0000269|PubMed:16109882, ECO:0000269|PubMed:17804805, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23756652, ECO:0000269|PubMed:23809763, ECO:0000269|PubMed:29769720}.	MISCELLANEOUS: Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis suggesting possible therapeutic application in gastrointestinal diseases.	positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of receptor internalization [GO:0002090]; Wnt signaling pathway [GO:0016055]	extracellular region [GO:0005576]; nucleus [GO:0005634]	G protein-coupled receptor binding [GO:0001664]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; nucleus [GO:0005634]; G protein-coupled receptor binding [GO:0001664]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of receptor internalization [GO:0002090]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9Z132}. Nucleus {ECO:0000250|UniProtKB:Q9Z132}. Note=Seems to mainly localize to nucleoli. {ECO:0000250|UniProtKB:Q9Z132}.
Q2MV58	reviewed	TECT1_HUMAN	Tectonic-1	TCTN1 TECT1 UNQ9369/PRO34160	Homo sapiens (Human)	587	FUNCTION: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	central nervous system interneuron axonogenesis [GO:0021956]; cilium assembly [GO:0060271]; dorsal/ventral neural tube patterning [GO:0021904]; in utero embryonic development [GO:0001701]; neural tube formation [GO:0001841]; protein localization to ciliary transition zone [GO:1904491]; regulation of smoothened signaling pathway [GO:0008589]; somatic motor neuron differentiation [GO:0021523]; telencephalon development [GO:0021537]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; MKS complex [GO:0036038]		cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; MKS complex [GO:0036038]; central nervous system interneuron axonogenesis [GO:0021956]; cilium assembly [GO:0060271]; dorsal/ventral neural tube patterning [GO:0021904]; in utero embryonic development [GO:0001701]; neural tube formation [GO:0001841]; protein localization to ciliary transition zone [GO:1904491]; regulation of smoothened signaling pathway [GO:0008589]; somatic motor neuron differentiation [GO:0021523]; telencephalon development [GO:0021537]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Secreted {ECO:0000305}. Note=Despite the presence of a signal sequence, the full-length protein might not be secreted. Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250}.
Q2NKJ3	reviewed	CTC1_HUMAN	CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B)	CTC1 C17orf68	Homo sapiens (Human)	1217	FUNCTION: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). Involved in telomere maintenance (PubMed:19854131, PubMed:22863775). Involved in genome stability (PubMed:22863775). May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity). {ECO:0000250|UniProtKB:Q5SUQ9, ECO:0000269|PubMed:19854130, ECO:0000269|PubMed:19854131, ECO:0000269|PubMed:22763445, ECO:0000269|PubMed:22863775, ECO:0000269|PubMed:25483097}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	bone marrow development [GO:0048539]; DNA damage response [GO:0006974]; hematopoietic stem cell proliferation [GO:0071425]; multicellular organism growth [GO:0035264]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA replication [GO:0045740]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; replicative senescence [GO:0090399]; spleen development [GO:0048536]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]; thymus development [GO:0048538]	chromosome, telomeric region [GO:0000781]; CST complex [GO:1990879]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	G-rich strand telomeric DNA binding [GO:0098505]; single-stranded DNA binding [GO:0003697]; telomeric DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; CST complex [GO:1990879]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; G-rich strand telomeric DNA binding [GO:0098505]; single-stranded DNA binding [GO:0003697]; telomeric DNA binding [GO:0042162]; bone marrow development [GO:0048539]; DNA damage response [GO:0006974]; hematopoietic stem cell proliferation [GO:0071425]; multicellular organism growth [GO:0035264]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA replication [GO:0045740]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; replicative senescence [GO:0090399]; spleen development [GO:0048536]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]; thymus development [GO:0048538]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19854130}. Chromosome, telomere {ECO:0000269|PubMed:19854130}. Note=A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo. {ECO:0000305}.
Q2NKQ1	reviewed	SGSM1_HUMAN	Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2)	SGSM1 KIAA1941 RUTBC2	Homo sapiens (Human)	1148	FUNCTION: Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B. {ECO:0000269|PubMed:22637480}.			cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8BPQ7}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:22637480}; Peripheral membrane protein {ECO:0000269|PubMed:22637480}. Cytoplasm {ECO:0000269|PubMed:22637480}. Note=Recruited to cytoplasmic vesicle membranes via its interaction with Rab family members, such as RAB9A. {ECO:0000269|PubMed:22637480}.
Q2NKX8	reviewed	ERC6L_HUMAN	DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15)	ERCC6L PICH	Homo sapiens (Human)	1250	FUNCTION: DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}.		cell cycle [GO:0007049]; cell division [GO:0051301]	cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; DNA translocase activity [GO:0015616]; helicase activity [GO:0004386]	cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; DNA translocase activity [GO:0015616]; helicase activity [GO:0004386]; cell cycle [GO:0007049]; cell division [GO:0051301]	SUBCELLULAR LOCATION: Chromosome, centromere {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17989990}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17218258}. Chromosome {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17671160, ECO:0000269|PubMed:17989990}. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset. {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17671160, ECO:0000269|PubMed:17956945, ECO:0000269|PubMed:17989990}.
Q2NL67	reviewed	PARP6_HUMAN	Protein mono-ADP-ribosyltransferase PARP6 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 17) (ARTD17) (Poly [ADP-ribose] polymerase 6) (PARP-6)	PARP6	Homo sapiens (Human)	630	FUNCTION: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}.		endoplasmic reticulum unfolded protein response [GO:0030968]; positive regulation of dendrite morphogenesis [GO:0050775]; protein auto-ADP-ribosylation [GO:0070213]	endoplasmic reticulum tubular network [GO:0071782]; nuclear envelope [GO:0005635]	kinase binding [GO:0019900]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; nucleotidyltransferase activity [GO:0016779]; protein serine/threonine kinase activator activity [GO:0043539]	endoplasmic reticulum tubular network [GO:0071782]; nuclear envelope [GO:0005635]; kinase binding [GO:0019900]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; nucleotidyltransferase activity [GO:0016779]; protein serine/threonine kinase activator activity [GO:0043539]; endoplasmic reticulum unfolded protein response [GO:0030968]; positive regulation of dendrite morphogenesis [GO:0050775]; protein auto-ADP-ribosylation [GO:0070213]	
Q2NL68	reviewed	PRSR3_HUMAN	Proline and serine-rich protein 3	PROSER3 C19orf55	Homo sapiens (Human)	480				centrosome [GO:0005813]; cytoplasm [GO:0005737]		centrosome [GO:0005813]; cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26638075}.
Q2PPJ7	reviewed	RGPA2_HUMAN	Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220)	RALGAPA2 C20orf74 KIAA1272	Homo sapiens (Human)	1873	FUNCTION: Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.		activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982]; activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16490346}.
Q2Q1W2	reviewed	LIN41_HUMAN	E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)	TRIM71 LIN41	Homo sapiens (Human)	868	FUNCTION: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233). {ECO:0000250|UniProtKB:Q1PSW8, ECO:0000269|PubMed:23125361, ECO:0000269|PubMed:28431233, ECO:0000305|PubMed:24239284}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to organic substance [GO:0071310]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; post-transcriptional regulation of gene expression [GO:0010608]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]	P-body [GO:0000932]	miRNA binding [GO:0035198]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	P-body [GO:0000932]; miRNA binding [GO:0035198]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to organic substance [GO:0071310]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; post-transcriptional regulation of gene expression [GO:0010608]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:23125361, ECO:0000269|PubMed:24239284}.
Q2QGD7	reviewed	ZXDC_HUMAN	Zinc finger protein ZXDC (ZXD-like zinc finger protein)	ZXDC ZXDL	Homo sapiens (Human)	858	FUNCTION: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. {ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:17696781}.	MISCELLANEOUS: [Isoform 3]: Doesn't interact with CIITA. Represses MHC class II transcription possibly via dominant-negative association with isoform 1. {ECO:0000305}.	positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	C2H2 zinc finger domain binding [GO:0070742]; LRR domain binding [GO:0030275]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	nucleus [GO:0005634]; C2H2 zinc finger domain binding [GO:0070742]; LRR domain binding [GO:0030275]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q2QL34	reviewed	MP17L_HUMAN	Mpv17-like protein (M-LP homolog) (M-LPH)	MPV17L	Homo sapiens (Human)	196	FUNCTION: [Isoform 1]: Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes (PubMed:16631601). Protective against the mitochondrial apoptotic cascade (PubMed:22306510). {ECO:0000269|PubMed:16631601, ECO:0000269|PubMed:22306510}.		cellular response to reactive oxygen species [GO:0034614]; negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; reactive oxygen species metabolic process [GO:0072593]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]		cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; cellular response to reactive oxygen species [GO:0034614]; negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; reactive oxygen species metabolic process [GO:0072593]	SUBCELLULAR LOCATION: [Isoform 1]: Peroxisome membrane {ECO:0000269|PubMed:16631601}; Multi-pass membrane protein.
Q2T9J0	reviewed	TYSD1_HUMAN	Peroxisomal leader peptide-processing protease (EC 3.4.21.-) (Trypsin domain-containing protein 1) [Cleaved into: Peroxisomal leader peptide-processing protease, 15 kDa form; Peroxisomal leader peptide-processing protease, 45 kDa form]	TYSND1	Homo sapiens (Human)	566	FUNCTION: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids. {ECO:0000269|PubMed:22002062}.		protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of fatty acid beta-oxidation [GO:0031998]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of fatty acid beta-oxidation [GO:0031998]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:22002062}.
Q2TAA5	reviewed	ALG11_HUMAN	GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.131) (Asparagine-linked glycosylation protein 11 homolog) (Glycolipid 2-alpha-mannosyltransferase)	ALG11 GT8	Homo sapiens (Human)	492	FUNCTION: Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain. {ECO:0000269|PubMed:20080937}.		oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein N-linked glycosylation [GO:0006487]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	alpha-1,2-mannosyltransferase activity [GO:0000026]; GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0004377]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; alpha-1,2-mannosyltransferase activity [GO:0000026]; GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0004377]; oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein N-linked glycosylation [GO:0006487]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:20080937}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:20080937}; Multi-pass membrane protein {ECO:0000305|PubMed:20080937}.
Q2TAC2	reviewed	CCD57_HUMAN	Coiled-coil domain-containing protein 57	CCDC57	Homo sapiens (Human)	915	FUNCTION: Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis. Critical interface between centrosome and microtubule-mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression. {ECO:0000269|PubMed:32402286}.		centriole replication [GO:0007099]; cilium assembly [GO:0060271]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule nucleation [GO:0007020]; positive regulation of mitotic cell cycle [GO:0045931]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle microtubule [GO:0005876]		centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle microtubule [GO:0005876]; centriole replication [GO:0007099]; cilium assembly [GO:0060271]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule nucleation [GO:0007020]; positive regulation of mitotic cell cycle [GO:0045931]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:32402286}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:32402286}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:32402286}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:32402286}. Note=Localizes to resolvable rings at the proximal end of centrioles (PubMed:32402286). In mitotic cells, localizes to spindle microtubules during metaphase (PubMed:32402286). {ECO:0000269|PubMed:32402286}.
Q2TAK8	reviewed	PWP3A_HUMAN	PWWP domain-containing DNA repair factor 3A (PWWP3A) (Mutated melanoma-associated antigen 1) (MUM-1) (PWWP domain-containing protein MUM1) (Protein expandere)	PWWP3A EXPAND1 MUM1	Homo sapiens (Human)	710	FUNCTION: Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. {ECO:0000269|PubMed:20347427}.	MISCELLANEOUS: Acts as an antigenic peptide recognized by cytolytic T-lymphocytes in a melanoma. {ECO:0000305|PubMed:7644523}.	chromatin organization [GO:0006325]; DNA repair [GO:0006281]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nucleosome binding [GO:0031491]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nucleosome binding [GO:0031491]; chromatin organization [GO:0006325]; DNA repair [GO:0006281]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20347427}. Note=Recruited to DNA damage sites via its interaction with the BRCT domain of TP53BP1.
Q2TAL6	reviewed	VWC2_HUMAN	Brorin (Brain-specific chordin-like protein) (von Willebrand factor C domain-containing protein 2)	VWC2 UNQ739/PRO1434	Homo sapiens (Human)	325	FUNCTION: BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity). {ECO:0000250}.		negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron differentiation [GO:0045666]	AMPA glutamate receptor complex [GO:0032281]; basement membrane [GO:0005604]; extracellular space [GO:0005615]; interstitial matrix [GO:0005614]; synapse [GO:0045202]		AMPA glutamate receptor complex [GO:0032281]; basement membrane [GO:0005604]; extracellular space [GO:0005615]; interstitial matrix [GO:0005614]; synapse [GO:0045202]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron differentiation [GO:0045666]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Synapse {ECO:0000250}.
Q2TAL8	reviewed	QRIC1_HUMAN	Transcriptional regulator QRICH1 (Glutamine-rich protein 1)	QRICH1	Homo sapiens (Human)	776	FUNCTION: Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152). {ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33384352}.		endoplasmic reticulum unfolded protein response [GO:0030968]; integrated stress response signaling [GO:0140467]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; response to endoplasmic reticulum stress [GO:0034976]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; endoplasmic reticulum unfolded protein response [GO:0030968]; integrated stress response signaling [GO:0140467]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33384352}. Cytoplasm {ECO:0000269|PubMed:30281152}. Cell membrane {ECO:0000269|PubMed:30281152}.
Q2TAY7	reviewed	SMU1_HUMAN	WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) [Cleaved into: WD40 repeat-containing protein SMU1, N-terminally processed]	SMU1	Homo sapiens (Human)	513	FUNCTION: Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (PubMed:24945353). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). {ECO:0000250|UniProtKB:Q76B40, ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166, ECO:0000305}.; FUNCTION: (Microbial infection) Required, together with IK, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. {ECO:0000269|PubMed:24945353}.		mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]		cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99M63}. Nucleus {ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166}. Nucleus speckle {ECO:0000250|UniProtKB:Q76B40}. Note=Colocalizes with SRSF1 in nuclear speckles. {ECO:0000250|UniProtKB:Q76B40}.
Q2TAZ0	reviewed	ATG2A_HUMAN	Autophagy-related protein 2 homolog A	ATG2A KIAA0404	Homo sapiens (Human)	1938	FUNCTION: Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:31271352, PubMed:30952800). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:31271352, PubMed:30952800). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:31271352, PubMed:30952800). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}.		autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; late nucleophagy [GO:0044805]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; reticulophagy [GO:0061709]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; organelle membrane contact site [GO:0044232]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]	lipid transfer activity [GO:0120013]; phosphatidylinositol-3-phosphate binding [GO:0032266]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; organelle membrane contact site [GO:0044232]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; lipid transfer activity [GO:0120013]; phosphatidylinositol-3-phosphate binding [GO:0032266]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; late nucleophagy [GO:0044805]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; reticulophagy [GO:0061709]	SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000269|PubMed:30952800}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96BY7}. Lipid droplet {ECO:0000250|UniProtKB:Q96BY7}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30952800}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53855}. Note=Localizes to endoplasmic reticulum-autophagosome contact sites. {ECO:0000269|PubMed:30952800}.
Q2TB90	reviewed	HKDC1_HUMAN	Hexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1)	HKDC1	Homo sapiens (Human)	917	FUNCTION: Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases (PubMed:30517626). Has low glucose phosphorylating activity compared to other hexokinases (PubMed:30517626). Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity). {ECO:0000250|UniProtKB:Q91W97, ECO:0000269|PubMed:30517626}.		carbohydrate phosphorylation [GO:0046835]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; photoreceptor inner segment [GO:0001917]	ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucose binding [GO:0005536]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; photoreceptor inner segment [GO:0001917]; ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucose binding [GO:0005536]; carbohydrate phosphorylation [GO:0046835]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30085091}. Mitochondrion membrane {ECO:0000305|PubMed:30517626}; Peripheral membrane protein {ECO:0000305}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q91W97}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrion. {ECO:0000305|PubMed:30517626}.
Q2TBA0	reviewed	KLH40_HUMAN	Kelch-like protein 40 (Kelch repeat and BTB domain-containing protein 5) (Sarcosynapsin)	KLHL40 KBTBD5 SRYP	Homo sapiens (Human)	621	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:23746549). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity). {ECO:0000250|UniProtKB:Q9D783, ECO:0000269|PubMed:23746549}.		negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; skeletal muscle fiber development [GO:0048741]; skeletal muscle fiber differentiation [GO:0098528]	A band [GO:0031672]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; I band [GO:0031674]		A band [GO:0031672]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; I band [GO:0031674]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; skeletal muscle fiber development [GO:0048741]; skeletal muscle fiber differentiation [GO:0098528]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D783}. Cytoplasm, myofibril, sarcomere, A band {ECO:0000269|PubMed:23746549}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:Q9D783}.
Q2TBE0	reviewed	C19L2_HUMAN	CWF19-like protein 2	CWF19L2	Homo sapiens (Human)	894		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mRNA splicing, via spliceosome [GO:0000398]	nucleoplasm [GO:0005654]; post-mRNA release spliceosomal complex [GO:0071014]		nucleoplasm [GO:0005654]; post-mRNA release spliceosomal complex [GO:0071014]; mRNA splicing, via spliceosome [GO:0000398]	
Q2UY09	reviewed	COSA1_HUMAN	Collagen alpha-1(XXVIII) chain	COL28A1 COL28	Homo sapiens (Human)	1125	FUNCTION: May act as a cell-binding protein.		cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]	basement membrane [GO:0005604]; collagen type V trimer [GO:0005588]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]	basement membrane [GO:0005604]; collagen type V trimer [GO:0005588]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]; cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}.
Q2V2M9	reviewed	FHOD3_HUMAN	FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2)	FHOD3 FHOS2 KIAA1695	Homo sapiens (Human)	1422	FUNCTION: Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes. {ECO:0000250, ECO:0000269|PubMed:21149568}.		cardiac myofibril assembly [GO:0055003]; cortical actin cytoskeleton organization [GO:0030866]; negative regulation of actin filament polymerization [GO:0030837]; sarcomere organization [GO:0045214]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]	actin filament binding [GO:0051015]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; cardiac myofibril assembly [GO:0055003]; cortical actin cytoskeleton organization [GO:0030866]; negative regulation of actin filament polymerization [GO:0030837]; sarcomere organization [GO:0045214]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21149568}. Note=Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm, myofibril, sarcomere, Z line. Note=Threonine phosphorylation in isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes.
Q2VIQ3	reviewed	KIF4B_HUMAN	Chromosome-associated kinesin KIF4B (Chromokinesin-B)	KIF4B	Homo sapiens (Human)	1234	FUNCTION: Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (By similarity). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:O95239, ECO:0000250|UniProtKB:P33174}.		microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; spindle elongation [GO:0051231]	cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; spindle elongation [GO:0051231]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250|UniProtKB:O95239}. Cytoplasm, cytoskeleton {ECO:0000305}.
Q2VPA4	reviewed	CR1L_HUMAN	Complement component receptor 1-like protein (Complement C4b-binding protein CR-1-like protein)	CR1L	Homo sapiens (Human)	569			negative regulation of complement activation, classical pathway [GO:0045959]; regulation of complement activation [GO:0030449]; regulation of complement-dependent cytotoxicity [GO:1903659]; T cell mediated immunity [GO:0002456]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]		cytoplasm [GO:0005737]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; negative regulation of complement activation, classical pathway [GO:0045959]; regulation of complement activation [GO:0030449]; regulation of complement-dependent cytotoxicity [GO:1903659]; T cell mediated immunity [GO:0002456]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14687939}. Membrane {ECO:0000269|PubMed:14687939}. Secreted {ECO:0000269|PubMed:14687939}. Note=Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant.
Q2VPK5	reviewed	CTU2_HUMAN	Cytoplasmic tRNA 2-thiolation protein 2 (Cytosolic thiouridylase subunit 2)	CTU2 C16orf84 NCS2	Homo sapiens (Human)	515	FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03054, ECO:0000269|PubMed:19017811}.	MISCELLANEOUS: [Isoform 3]: Incomplete sequence. {ECO:0000305}.	protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble position uridine thiolation [GO:0002143]; tRNA wobble uridine modification [GO:0002098]	cytosol [GO:0005829]; protein-containing complex [GO:0032991]	nucleotidyltransferase activity [GO:0016779]; sulfurtransferase activity [GO:0016783]; tRNA binding [GO:0000049]	cytosol [GO:0005829]; protein-containing complex [GO:0032991]; nucleotidyltransferase activity [GO:0016779]; sulfurtransferase activity [GO:0016783]; tRNA binding [GO:0000049]; protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble position uridine thiolation [GO:0002143]; tRNA wobble uridine modification [GO:0002098]	SUBCELLULAR LOCATION: Cytoplasm.
Q2VWA4	reviewed	SKOR2_HUMAN	SKI family transcriptional corepressor 2 (Functional Smad-suppressing element on chromosome 18) (Fussel-18) (LBX1 corepressor 1-like protein) (Ladybird homeobox corepressor 1-like protein)	SKOR2 CORL2 FUSSEL18	Homo sapiens (Human)	1015	FUNCTION: Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system. {ECO:0000250, ECO:0000269|PubMed:16200078}.		cell development [GO:0048468]; cerebellar Purkinje cell differentiation [GO:0021702]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cerebellar granule cell precursor proliferation [GO:0021936]; regulation of dendrite morphogenesis [GO:0048814]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuroblast proliferation [GO:1902692]; smoothened signaling pathway [GO:0007224]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]; cell development [GO:0048468]; cerebellar Purkinje cell differentiation [GO:0021702]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cerebellar granule cell precursor proliferation [GO:0021936]; regulation of dendrite morphogenesis [GO:0048814]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuroblast proliferation [GO:1902692]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16200078}. Cytoplasm {ECO:0000269|PubMed:16200078}.
Q2WEN9	reviewed	CEA16_HUMAN	Carcinoembryonic antigen-related cell adhesion molecule 16 (Carcinoembryonic antigen-like 2)	CEACAM16 CEAL2	Homo sapiens (Human)	425	FUNCTION: Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane. {ECO:0000269|PubMed:21368133, ECO:0000269|PubMed:25589040, ECO:0000269|PubMed:29703829}.		sensory perception of sound [GO:0007605]	extracellular space [GO:0005615]; stereocilium tip [GO:0032426]	identical protein binding [GO:0042802]	extracellular space [GO:0005615]; stereocilium tip [GO:0032426]; identical protein binding [GO:0042802]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25589040}. Note=Localizes to the tip of cochlear outer hair cells and to the tectorial membrane. {ECO:0000250|UniProtKB:E9QA28}.
Q2WGJ6	reviewed	KLH38_HUMAN	Kelch-like protein 38	KLHL38 C8orfK36	Homo sapiens (Human)	581							
Q2Y0W8	reviewed	S4A8_HUMAN	Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3)	SLC4A8 KIAA0739 NBC NBC3 NDCBE1	Homo sapiens (Human)	1093	FUNCTION: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:18577713). Plays a major role in pH regulation in neurons (By similarity). Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity). {ECO:0000250|UniProtKB:Q8JZR6, ECO:0000269|PubMed:18577713}.	MISCELLANEOUS: [Isoform 3]: May be due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be due to an intron retention. {ECO:0000305}.	basolateral protein secretion [GO:0110010]; bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; sodium ion transmembrane transport [GO:0035725]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; asymmetric synapse [GO:0032279]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber [GO:0097457]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; symmetric synapse [GO:0032280]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; identical protein binding [GO:0042802]; sodium ion transmembrane transporter activity [GO:0015081]; sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; asymmetric synapse [GO:0032279]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber [GO:0097457]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; symmetric synapse [GO:0032280]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; identical protein binding [GO:0042802]; sodium ion transmembrane transporter activity [GO:0015081]; sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]; zinc ion binding [GO:0008270]; basolateral protein secretion [GO:0110010]; bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; sodium ion transmembrane transport [GO:0035725]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:17715183}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q6RVG2}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q6RVG2}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:18577713}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:18577713}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:18577713}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane {ECO:0000269|PubMed:18577713}; Multi-pass membrane protein {ECO:0000255}.
Q2YD98	reviewed	UVSSA_HUMAN	UV-stimulated scaffold protein A	UVSSA KIAA1530	Homo sapiens (Human)	709	FUNCTION: Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (PubMed:22466610, PubMed:22466611, PubMed:22466612). Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites (PubMed:22466611, PubMed:32142649). Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome (PubMed:22466611, PubMed:22466612). Also facilitates transfer of TFIIH to RNA polymerase II (PubMed:32142649). Not involved in processing oxidative damage (PubMed:22466612). {ECO:0000269|PubMed:22466610, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:32142649}.		protein ubiquitination [GO:0016567]; response to UV [GO:0009411]; transcription-coupled nucleotide-excision repair [GO:0006283]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]	RNA polymerase II complex binding [GO:0000993]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; RNA polymerase II complex binding [GO:0000993]; protein ubiquitination [GO:0016567]; response to UV [GO:0009411]; transcription-coupled nucleotide-excision repair [GO:0006283]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612}. Note=Accumulates at UV DNA damage sites. {ECO:0000269|PubMed:22466611}.
Q30154	reviewed	DRB5_HUMAN	HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5)	HLA-DRB5	Homo sapiens (Human)	266	FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.		adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]	MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]	clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658]; MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173, ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173, ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173, ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173, ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173, ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173, ECO:0000305}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Q30201	reviewed	HFE_HUMAN	Hereditary hemochromatosis protein (HLA-H)	HFE HLAH	Homo sapiens (Human)	348	FUNCTION: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. {ECO:0000269|PubMed:9465039}.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.	acute-phase response [GO:0006953]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; BMP signaling pathway [GO:0030509]; cellular response to iron ion [GO:0071281]; cellular response to iron ion starvation [GO:0010106]; female pregnancy [GO:0007565]; hormone biosynthetic process [GO:0042446]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; liver regeneration [GO:0097421]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:1904283]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of receptor binding [GO:1900121]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of ferrous iron binding [GO:1904434]; positive regulation of gene expression [GO:0010628]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor binding [GO:1900122]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transferrin receptor binding [GO:1904437]; protein-containing complex assembly [GO:0065003]; regulation of iron ion transport [GO:0034756]; regulation of protein localization to cell surface [GO:2000008]; response to iron ion [GO:0010039]; response to iron ion starvation [GO:1990641]	apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; terminal web [GO:1990357]	beta-2-microglobulin binding [GO:0030881]; co-receptor binding [GO:0039706]; signaling receptor binding [GO:0005102]; transferrin receptor binding [GO:1990459]	apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; terminal web [GO:1990357]; beta-2-microglobulin binding [GO:0030881]; co-receptor binding [GO:0039706]; signaling receptor binding [GO:0005102]; transferrin receptor binding [GO:1990459]; acute-phase response [GO:0006953]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; BMP signaling pathway [GO:0030509]; cellular response to iron ion [GO:0071281]; cellular response to iron ion starvation [GO:0010106]; female pregnancy [GO:0007565]; hormone biosynthetic process [GO:0042446]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; liver regeneration [GO:0097421]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:1904283]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of receptor binding [GO:1900121]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of ferrous iron binding [GO:1904434]; positive regulation of gene expression [GO:0010628]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor binding [GO:1900122]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transferrin receptor binding [GO:1904437]; protein-containing complex assembly [GO:0065003]; regulation of iron ion transport [GO:0034756]; regulation of protein localization to cell surface [GO:2000008]; response to iron ion [GO:0010039]; response to iron ion starvation [GO:1990641]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9465039}; Single-pass type I membrane protein {ECO:0000305|PubMed:8696333}.
Q30KQ6	reviewed	DB114_HUMAN	Beta-defensin 114 (Beta-defensin 14) (DEFB-14) (Defensin, beta 114)	DEFB114 DEFB14	Homo sapiens (Human)	69	FUNCTION: Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. {ECO:0000269|PubMed:23482568}.		antifungal innate immune response [GO:0061760]; cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of inflammatory response [GO:0050729]	extracellular space [GO:0005615]	CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]; lipopolysaccharide binding [GO:0001530]	extracellular space [GO:0005615]; CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]; lipopolysaccharide binding [GO:0001530]; antifungal innate immune response [GO:0061760]; cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of inflammatory response [GO:0050729]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q32M45	reviewed	ANO4_HUMAN	Anoctamin-4 (Transmembrane protein 16D)	ANO4 TMEM16D	Homo sapiens (Human)	955	FUNCTION: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). {ECO:0000250|UniProtKB:Q8C5H1}.	MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.	calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; establishment of localization in cell [GO:0051649]; monoatomic ion transmembrane transport [GO:0034220]	plasma membrane [GO:0005886]	intracellular calcium activated chloride channel activity [GO:0005229]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983]	plasma membrane [GO:0005886]; intracellular calcium activated chloride channel activity [GO:0005229]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983]; calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; establishment of localization in cell [GO:0051649]; monoatomic ion transmembrane transport [GO:0034220]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000269|PubMed:22946059}. Note=Shows an intracellular localization. {ECO:0000250|UniProtKB:Q8C5H1}.
Q32M88	reviewed	PGGHG_HUMAN	Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107) (Acid trehalase-like protein 1)	PGGHG ATHL1	Homo sapiens (Human)	737	FUNCTION: Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. {ECO:0000269|PubMed:26682924}.		carbohydrate metabolic process [GO:0005975]	cytosol [GO:0005829]	protein-glucosylgalactosylhydroxylysine glucosidase activity [GO:0047402]	cytosol [GO:0005829]; protein-glucosylgalactosylhydroxylysine glucosidase activity [GO:0047402]; carbohydrate metabolic process [GO:0005975]	
Q32MK0	reviewed	MYLK3_HUMAN	Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK)	MYLK3 MLCK	Homo sapiens (Human)	819	FUNCTION: Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}.		cardiac myofibril assembly [GO:0055003]; cellular response to interleukin-1 [GO:0071347]; positive regulation of sarcomere organization [GO:0060298]; protein phosphorylation [GO:0006468]; regulation of vascular permeability involved in acute inflammatory response [GO:0002528]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; calmodulin-dependent protein kinase activity [GO:0004683]; myosin light chain kinase activity [GO:0004687]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; calmodulin-dependent protein kinase activity [GO:0004683]; myosin light chain kinase activity [GO:0004687]; cardiac myofibril assembly [GO:0055003]; cellular response to interleukin-1 [GO:0071347]; positive regulation of sarcomere organization [GO:0060298]; protein phosphorylation [GO:0006468]; regulation of vascular permeability involved in acute inflammatory response [GO:0002528]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q32MQ0	reviewed	ZN750_HUMAN	Zinc finger protein 750	ZNF750	Homo sapiens (Human)	723	FUNCTION: Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression. {ECO:0000269|PubMed:22364861}.		cell differentiation [GO:0030154]; epidermis development [GO:0008544]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell differentiation [GO:0030154]; epidermis development [GO:0008544]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22364861}.
Q32MZ4	reviewed	LRRF1_HUMAN	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein)	LRRFIP1 GCF2 TRIP	Homo sapiens (Human)	808	FUNCTION: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded RNA binding [GO:0003725]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded RNA binding [GO:0003725]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
Q32NB8	reviewed	PGPS1_HUMAN	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase 1) (PGP synthase 1)	PGS1	Homo sapiens (Human)	556	FUNCTION: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. {ECO:0000250}.		cardiolipin biosynthetic process [GO:0032049]; diacylglycerol metabolic process [GO:0046339]; phosphatidylglycerol biosynthetic process [GO:0006655]	endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [GO:0008444]	endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [GO:0008444]; cardiolipin biosynthetic process [GO:0032049]; diacylglycerol metabolic process [GO:0046339]; phosphatidylglycerol biosynthetic process [GO:0006655]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
Q32P28	reviewed	P3H1_HUMAN	Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1)	P3H1 GROS1 LEPRE1 PSEC0109	Homo sapiens (Human)	736	FUNCTION: Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. {ECO:0000269|PubMed:10951563}.		bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of post-translational protein modification [GO:1901874]; positive regulation of neuron projection development [GO:0010976]; protein folding [GO:0006457]; protein hydroxylation [GO:0018126]; protein stabilization [GO:0050821]; regulation of protein secretion [GO:0050708]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797]; bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of post-translational protein modification [GO:1901874]; positive regulation of neuron projection development [GO:0010976]; protein folding [GO:0006457]; protein hydroxylation [GO:0018126]; protein stabilization [GO:0050821]; regulation of protein secretion [GO:0050708]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum {ECO:0000269|PubMed:19088120}.; SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9R1J8}. Note=Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan (CSPG). {ECO:0000250|UniProtKB:Q9R1J8}.
Q32P41	reviewed	TRM5_HUMAN	tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog)	TRMT5 KIAA1393 TRM5	Homo sapiens (Human)	509	FUNCTION: Involved in mitochondrial tRNA methylation (PubMed:26189817). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. {ECO:0000269|PubMed:26189817}.		mitochondrial tRNA methylation [GO:0070901]; tRNA N1-guanine methylation [GO:0002939]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]	tRNA (guanine(37)-N(1))-methyltransferase activity [GO:0052906]; tRNA (guanine-N1-)-methyltransferase activity [GO:0009019]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; tRNA (guanine(37)-N(1))-methyltransferase activity [GO:0052906]; tRNA (guanine-N1-)-methyltransferase activity [GO:0009019]; mitochondrial tRNA methylation [GO:0070901]; tRNA N1-guanine methylation [GO:0002939]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03152, ECO:0000269|PubMed:26189817}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03152}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03152}. Note=Predominantly in the mitochondria and in the nucleus. {ECO:0000255|HAMAP-Rule:MF_03152}.
Q32P44	reviewed	EMAL3_HUMAN	Echinoderm microtubule-associated protein-like 3 (EMAP-3)	EML3	Homo sapiens (Human)	896	FUNCTION: Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; mitotic metaphase chromosome alignment [GO:0007080]; regulation of mitotic spindle assembly [GO:1901673]	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle microtubule [GO:1990498]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]	microtubule binding [GO:0008017]; protein self-association [GO:0043621]	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle microtubule [GO:1990498]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; microtubule binding [GO:0008017]; protein self-association [GO:0043621]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; mitotic metaphase chromosome alignment [GO:0007080]; regulation of mitotic spindle assembly [GO:1901673]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18445686, ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18445686}. Nucleus {ECO:0000269|PubMed:18445686}. Midbody {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. Note=Localizes to microtubules throughout all mitotic stages and localizes to the midbody during cytokinesis. {ECO:0000269|PubMed:18445686}.
Q330K2	reviewed	NDUF6_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 (Putative phytoene synthase)	NDUFAF6 C8orf38	Homo sapiens (Human)	333	FUNCTION: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of complex I subunit MT-ND1. {ECO:0000269|PubMed:18614015, ECO:0000269|PubMed:22019594}.		biosynthetic process [GO:0009058]; mitochondrial respiratory chain complex I assembly [GO:0032981]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; biosynthetic process [GO:0009058]; mitochondrial respiratory chain complex I assembly [GO:0032981]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane. Note=Peripherally localized on the matrix face of the mitochondrial inner membrane.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.
Q33E94	reviewed	RFX4_HUMAN	Transcription factor RFX4 (Regulatory factor X 4) (Testis development protein NYD-SP10)	RFX4	Homo sapiens (Human)	735	FUNCTION: Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development. {ECO:0000250|UniProtKB:Q7TNK1}.		cilium assembly [GO:0060271]; negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021914]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of protein processing [GO:0070613]; regulation of transcription by RNA polymerase II [GO:0006357]; telencephalon development [GO:0021537]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cilium assembly [GO:0060271]; negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021914]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of protein processing [GO:0070613]; regulation of transcription by RNA polymerase II [GO:0006357]; telencephalon development [GO:0021537]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858}.
Q38SD2	reviewed	LRRK1_HUMAN	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)	LRRK1 KIAA1790	Homo sapiens (Human)	2015	FUNCTION: Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts. {ECO:0000250|UniProtKB:Q3UHC2}.		bone resorption [GO:0045453]; intracellular signal transduction [GO:0035556]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; osteoclast development [GO:0036035]; phosphorylation [GO:0016310]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; bone resorption [GO:0045453]; intracellular signal transduction [GO:0035556]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; osteoclast development [GO:0036035]; phosphorylation [GO:0016310]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16243488}.
Q3B7T1	reviewed	EDRF1_HUMAN	Erythroid differentiation-related factor 1	EDRF1 C10orf137	Homo sapiens (Human)	1238	FUNCTION: Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene. {ECO:0000269|PubMed:12609092}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	positive regulation of DNA-templated transcription [GO:0045893]	nucleus [GO:0005634]		nucleus [GO:0005634]; positive regulation of DNA-templated transcription [GO:0045893]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q3B820	reviewed	F161A_HUMAN	Protein FAM161A	FAM161A	Homo sapiens (Human)	660	FUNCTION: Involved in ciliogenesis. {ECO:0000269|PubMed:22940612}.		cilium assembly [GO:0060271]; cilium organization [GO:0044782]; positive regulation of protein acetylation [GO:1901985]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	astral microtubule [GO:0000235]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; spindle microtubule [GO:0005876]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	astral microtubule [GO:0000235]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; spindle microtubule [GO:0005876]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; cilium assembly [GO:0060271]; cilium organization [GO:0044782]; positive regulation of protein acetylation [GO:1901985]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22940612}. Cell projection, cilium {ECO:0000269|PubMed:22940612}. Note=Localized to the region between the outer and inner photoreceptor segments, corresponding to the photoreceptor connecting cilium.
Q3KNS1	reviewed	PTHD3_HUMAN	Patched domain-containing protein 3 (Patched-related protein)	PTCHD3 PTR	Homo sapiens (Human)	954	FUNCTION: May play a role in sperm development or sperm function (PubMed:17904097). However, does not appear to have an essential role in spermatogenesis or male fertility (PubMed:21439084). {ECO:0000269|PubMed:17904097, ECO:0000269|PubMed:21439084}.			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:17904097}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21439084}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the midpiece of the sperm tail. {ECO:0000269|PubMed:17904097}.
Q3KNS6	reviewed	ZN829_HUMAN	Zinc finger protein 829	ZNF829	Homo sapiens (Human)	432	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q3KNV8	reviewed	PCGF3_HUMAN	Polycomb group RING finger protein 3 (RING finger protein 3A)	PCGF3 RNF3 RNF3A	Homo sapiens (Human)	242	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). {ECO:0000250|UniProtKB:Q8BTQ0, ECO:0000269|PubMed:26151332}.		inactivation of X chromosome by genomic imprinting [GO:0060819]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; X chromosome [GO:0000805]	histone H2AK119 ubiquitin ligase activity [GO:0140862]; metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; X chromosome [GO:0000805]; histone H2AK119 ubiquitin ligase activity [GO:0140862]; metal ion binding [GO:0046872]; inactivation of X chromosome by genomic imprinting [GO:0060819]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8BTQ0}. Note=Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome. {ECO:0000250|UniProtKB:Q8BTQ0}.
Q3KNW5	reviewed	SOAT_HUMAN	Sodium-dependent organic anion transporter (SOAT) (Solute carrier family 10 member 6) (SLC10A6)	SLC10A6 SOAT	Homo sapiens (Human)	377	FUNCTION: Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis (PubMed:17491011, PubMed:23667501, PubMed:24717977, PubMed:28951227). Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids (PubMed:23667501, PubMed:24717977). May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (By similarity). May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium (PubMed:24717977). Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes (PubMed:17491011). {ECO:0000250|UniProtKB:Q9CXB2, ECO:0000269|PubMed:17491011, ECO:0000269|PubMed:23667501, ECO:0000269|PubMed:24717977, ECO:0000269|PubMed:28951227}.	MISCELLANEOUS: In humans, 3-beta-sulfooxy-androst-5-en-17-one (DHEAS) is the most abundant circulating steroid sulfate in the human body, it is mainly synthesized from adrenal glands and gonads, whereas rats and mice have low circulating concentrations of DHEAS in the periphery as they can only produce DHEAS in their gonads. {ECO:0000250|UniProtKB:Q9CXB2}.	bile acid and bile salt transport [GO:0015721]; sodium-dependent organic anion transport [GO:0043251]; transmembrane transport [GO:0055085]	plasma membrane [GO:0005886]	bile acid:sodium symporter activity [GO:0008508]; sodium-dependent organic anion transmembrane transporter activity [GO:0043250]	plasma membrane [GO:0005886]; bile acid:sodium symporter activity [GO:0008508]; sodium-dependent organic anion transmembrane transporter activity [GO:0043250]; bile acid and bile salt transport [GO:0015721]; sodium-dependent organic anion transport [GO:0043251]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:23667501}; Multi-pass membrane protein {ECO:0000305}.
Q3KP22	reviewed	MAJIN_HUMAN	Membrane-anchored junction protein	MAJIN C11orf85	Homo sapiens (Human)	176	FUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9D992}.		double-strand break repair involved in meiotic recombination [GO:1990918]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]	chromosome, telomeric region [GO:0000781]; nuclear inner membrane [GO:0005637]	DNA binding [GO:0003677]	chromosome, telomeric region [GO:0000781]; nuclear inner membrane [GO:0005637]; DNA binding [GO:0003677]; double-strand break repair involved in meiotic recombination [GO:1990918]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:Q9D992}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9D992}. Chromosome, telomere {ECO:0000250|UniProtKB:Q9D992}. Note=In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9D992}.
Q3KP44	reviewed	ANR55_HUMAN	Ankyrin repeat domain-containing protein 55	ANKRD55	Homo sapiens (Human)	614							
Q3KP66	reviewed	INAVA_HUMAN	Innate immunity activator protein	INAVA C1orf106	Homo sapiens (Human)	663	FUNCTION: Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). {ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:29420262}.		adherens junction maintenance [GO:0034334]; innate immune response [GO:0045087]; intestinal epithelial structure maintenance [GO:0060729]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of stress-activated MAPK cascade [GO:0032874]; reactive oxygen species biosynthetic process [GO:1903409]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; adherens junction maintenance [GO:0034334]; innate immune response [GO:0045087]; intestinal epithelial structure maintenance [GO:0060729]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of stress-activated MAPK cascade [GO:0032874]; reactive oxygen species biosynthetic process [GO:1903409]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28436939}. Cytoplasm {ECO:0000269|PubMed:28436939}. Note=Translocates to the nucleus upon NOD2 stimulation. {ECO:0000269|PubMed:28436939}.
Q3KQV3	reviewed	ZN792_HUMAN	Zinc finger protein 792	ZNF792	Homo sapiens (Human)	632	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q3KR16	reviewed	PKHG6_HUMAN	Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)	PLEKHG6	Homo sapiens (Human)	790	FUNCTION: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}.		regulation of small GTPase mediated signal transduction [GO:0051056]	cell junction [GO:0030054]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; microvillus [GO:0005902]; spindle pole [GO:0000922]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	cell junction [GO:0030054]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; microvillus [GO:0005902]; spindle pole [GO:0000922]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cell projection, microvillus {ECO:0000269|PubMed:17881735}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16721066}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16721066}. Cleavage furrow {ECO:0000269|PubMed:16721066}. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow (PubMed:16721066). In epithelial cells, recruited to the apical membrane by EZR where it participates in macropinocytosis (PubMed:17881735). {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}.
Q3KR37	reviewed	ASTRB_HUMAN	Protein Aster-B (GRAM domain-containing protein 1B)	GRAMD1B KIAA1201 UNQ3032/PRO9834	Homo sapiens (Human)	738	FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}.		cellular response to cholesterol [GO:0071397]; cholesterol homeostasis [GO:0042632]; intracellular sterol transport [GO:0032366]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; phosphatidic acid binding [GO:0070300]; phosphatidylserine binding [GO:0001786]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; phosphatidic acid binding [GO:0070300]; phosphatidylserine binding [GO:0001786]; cellular response to cholesterol [GO:0071397]; cholesterol homeostasis [GO:0042632]; intracellular sterol transport [GO:0032366]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS). {ECO:0000269|PubMed:30220461}.
Q3KRA9	reviewed	ALKB6_HUMAN	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 6)	ALKBH6 ABH6	Homo sapiens (Human)	238	FUNCTION: Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000250}.			cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17979886}. Nucleus {ECO:0000269|PubMed:17979886}.
Q3KRB8	reviewed	RHGBB_HUMAN	Inactive Rho GTPase-activating protein 11B (Rho-type GTPase-activating protein 11B)	ARHGAP11B FAM7B1	Homo sapiens (Human)	267	FUNCTION: Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex (PubMed:25721503, PubMed:27957544, PubMed:30484771, PubMed:32554627, PubMed:33938018). Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion (PubMed:25721503). Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation (PubMed:31883789). Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development (PubMed:25721503, PubMed:27957544). {ECO:0000269|PubMed:25721503, ECO:0000269|PubMed:27957544, ECO:0000269|PubMed:30484771, ECO:0000269|PubMed:31883789, ECO:0000269|PubMed:32554627, ECO:0000269|PubMed:33938018}.	MISCELLANEOUS: When expressed in embryonic mouse neocortex, promotes basal progenitor generation and self-renewal, and can increase cortical plate area and induce gyrification (PubMed:25721503, PubMed:33938018). Mice exhibit increased neocortical size and upper-layer neuron numbers persisting into adulthood (PubMed:33938018). Moreover, mice display altered neurobehaviour, characterized by an increased memory flexibility and a reduced anxiety level (PubMed:33938018). When expressed in the developing neocortex of the gyrencephalic ferret, strongly increases proliferative basal radial glia, a progenitor cell type thought to be instrumental for neocortical expansion, resulting in extension of the neurogenic period and an increase in upper-layer neurons (PubMed:30484771). As consequence, the postnatal ferret neocortex displays increased neuron density in the upper cortical layers and expands in both the radial and tangential dimensions (PubMed:30484771). Expression in fetal neocortex of the common marmoset increases the numbers of upper-layer neurons, promoting enlargement of the neocortex and inducing its folding (PubMed:32554627). {ECO:0000269|PubMed:25721503, ECO:0000269|PubMed:30484771, ECO:0000269|PubMed:32554627, ECO:0000269|PubMed:33938018}.; MISCELLANEOUS: ARHGAP11B arose from partial duplication of ARHGAP11A on the human lineage after separation from the chimpanzee lineage, but before the divergence from Neandertals. {ECO:0000269|PubMed:25721503, ECO:0000269|PubMed:28580430}.	cerebral cortex development [GO:0021987]; glutamine catabolic process [GO:0006543]; negative regulation of mitochondrial membrane permeability [GO:0035795]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; GTPase activator activity [GO:0005096]; cerebral cortex development [GO:0021987]; glutamine catabolic process [GO:0006543]; negative regulation of mitochondrial membrane permeability [GO:0035795]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:31883789}.
Q3L8U1	reviewed	CHD9_HUMAN	Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein)	CHD9 KIAA0308 KISH2 PRIC320 AD-013 x0008	Homo sapiens (Human)	2897	FUNCTION: Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}.			cytosol [GO:0005829]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16095617}. Nucleus {ECO:0000269|PubMed:16095617}.
Q3LHN2	reviewed	KR192_HUMAN	Keratin-associated protein 19-2	KRTAP19-2 KAP19.2	Homo sapiens (Human)	52	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3LI59	reviewed	KR212_HUMAN	Keratin-associated protein 21-2	KRTAP21-2 KAP21.2	Homo sapiens (Human)	83	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3LI64	reviewed	KRA61_HUMAN	Keratin-associated protein 6-1	KRTAP6-1 C21orf103 KAP6.1	Homo sapiens (Human)	71	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.		keratinization [GO:0031424]	cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]; keratinization [GO:0031424]	
Q3LI66	reviewed	KRA62_HUMAN	Keratin-associated protein 6-2	KRTAP6-2 KAP6.2	Homo sapiens (Human)	62	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.		keratinization [GO:0031424]	cytosol [GO:0005829]; intermediate filament [GO:0005882]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; intermediate filament [GO:0005882]; identical protein binding [GO:0042802]; keratinization [GO:0031424]	
Q3LI70	reviewed	KR196_HUMAN	Keratin-associated protein 19-6	KRTAP19-6 KAP19.6	Homo sapiens (Human)	58	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3LI72	reviewed	KR195_HUMAN	Keratin-associated protein 19-5	KRTAP19-5 KAP19.5	Homo sapiens (Human)	72	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3LI76	reviewed	KR151_HUMAN	Keratin-associated protein 15-1	KRTAP15-1 KAP15.1	Homo sapiens (Human)	137	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3LIE5	reviewed	ADPRM_HUMAN	Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.13) (EC 3.6.1.16) (EC 3.6.1.53) (ADPRibase-Mn) (CDP-choline phosphohydrolase)	ADPRM C17orf48 MDS006 Nbla03831	Homo sapiens (Human)	342	FUNCTION: Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytosol [GO:0005829]	2',3'-cyclic-nucleotide 2'-phosphodiesterase activity [GO:0008663]; ADP-ribose diphosphatase activity [GO:0047631]; CDP-glycerol diphosphatase activity [GO:0047734]; manganese ion binding [GO:0030145]	cytosol [GO:0005829]; 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity [GO:0008663]; ADP-ribose diphosphatase activity [GO:0047631]; CDP-glycerol diphosphatase activity [GO:0047734]; manganese ion binding [GO:0030145]	
Q3LXA3	reviewed	TKFC_HUMAN	Triokinase/FMN cyclase (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)]	TKFC DAK	Homo sapiens (Human)	575	FUNCTION: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090). {ECO:0000250|UniProtKB:F1RKQ4, ECO:0000250|UniProtKB:Q4KLZ6, ECO:0000269|PubMed:16289032, ECO:0000269|PubMed:17600090, ECO:0000269|PubMed:32004446, ECO:0000269|PubMed:4688871}.	MISCELLANEOUS: [Isoform 2]: Inactive as DHA kinase and FMN cyclase. {ECO:0000305}.	carbohydrate metabolic process [GO:0005975]; carbohydrate phosphorylation [GO:0046835]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; glycerol catabolic process [GO:0019563]; negative regulation of MDA-5 signaling pathway [GO:0039534]; regulation of innate immune response [GO:0045088]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	ATP binding [GO:0005524]; FAD-AMP lyase (cyclizing) activity [GO:0034012]; glycerone kinase activity [GO:0004371]; metal ion binding [GO:0046872]; triokinase activity [GO:0050354]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ATP binding [GO:0005524]; FAD-AMP lyase (cyclizing) activity [GO:0034012]; glycerone kinase activity [GO:0004371]; metal ion binding [GO:0046872]; triokinase activity [GO:0050354]; carbohydrate metabolic process [GO:0005975]; carbohydrate phosphorylation [GO:0046835]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; glycerol catabolic process [GO:0019563]; negative regulation of MDA-5 signaling pathway [GO:0039534]; regulation of innate immune response [GO:0045088]	
Q3MHD2	reviewed	LSM12_HUMAN	Protein LSM12	LSM12	Homo sapiens (Human)	195	FUNCTION: Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein (PubMed:34362892). Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release (PubMed:34362892). {ECO:0000269|PubMed:34362892}.			cytoplasm [GO:0005737]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34362892}. Note=Colocalizes with TPCN2. {ECO:0000269|PubMed:34362892}.
Q3MII6	reviewed	TBC25_HUMAN	TBC1 domain family member 25	TBC1D25 OATL1	Homo sapiens (Human)	688	FUNCTION: Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. {ECO:0000269|PubMed:21383079}.		autophagy [GO:0006914]; regulation of autophagosome maturation [GO:1901096]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]	GTPase activator activity [GO:0005096]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; GTPase activator activity [GO:0005096]; autophagy [GO:0006914]; regulation of autophagosome maturation [GO:1901096]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21383079}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:21383079}. Note=It is dispersed in the cytoplasm under nutrient-rich conditions. Localizes at autophagosomes under cell starving conditions.
Q3MIR4	reviewed	CC50B_HUMAN	Cell cycle control protein 50B (P4-ATPase flippase complex beta subunit TMEM30B) (Transmembrane protein 30B)	TMEM30B CDC50B	Homo sapiens (Human)	351	FUNCTION: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane. {ECO:0000269|PubMed:20961850, ECO:0000305}.		aminophospholipid transport [GO:0015917]; phospholipid translocation [GO:0045332]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]	aminophospholipid flippase activity [GO:0015247]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; aminophospholipid flippase activity [GO:0015247]; aminophospholipid transport [GO:0015917]; phospholipid translocation [GO:0045332]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20961850}; Multi-pass membrane protein {ECO:0000269|PubMed:20961850}.
Q3MIT2	reviewed	PUS10_HUMAN	tRNA pseudouridine synthase Pus10 (Hup10) (EC 5.4.99.25) (Coiled-coil domain-containing protein 139) (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase)	PUS10 CCDC139 DOBI	Homo sapiens (Human)	529	FUNCTION: Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm (PubMed:31819270, PubMed:33023933). In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs (PubMed:30530625, PubMed:31819270, PubMed:33023933). tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs (PubMed:30530625). Does not show tRNA pseudouridylate synthase activity in the nucleus (PubMed:33023933). In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity (PubMed:31819270). Binds pri-miRNAs (PubMed:31819270). Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage (PubMed:14527409, PubMed:19712588). Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death (PubMed:19712588). {ECO:0000269|PubMed:14527409, ECO:0000269|PubMed:19712588, ECO:0000269|PubMed:30530625, ECO:0000269|PubMed:31819270, ECO:0000269|PubMed:33023933}.		primary miRNA processing [GO:0031053]; tRNA pseudouridine synthesis [GO:0031119]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; pseudouridine synthase activity [GO:0009982]; tRNA pseudouridine synthase activity [GO:0106029]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; pseudouridine synthase activity [GO:0009982]; tRNA pseudouridine synthase activity [GO:0106029]; primary miRNA processing [GO:0031053]; tRNA pseudouridine synthesis [GO:0031119]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28981101, ECO:0000269|PubMed:30530625, ECO:0000269|PubMed:31819270, ECO:0000269|PubMed:33023933}. Cytoplasm {ECO:0000269|PubMed:31819270, ECO:0000269|PubMed:33023933, ECO:0000305|PubMed:30530625}. Mitochondrion {ECO:0000269|PubMed:28981101}. Note=Localizes mainly in the nucleus (Probable) (PubMed:31819270). tRNA pseudouridylate synthase activity is restricted to the cytoplasm (PubMed:31819270). Translocates from nucleus to mitochondria during TRAIL-induced apoptosis (PubMed:28981101). {ECO:0000269|PubMed:28981101, ECO:0000269|PubMed:31819270, ECO:0000305|PubMed:30530625}.
Q3MJ16	reviewed	PA24E_HUMAN	Cytosolic phospholipase A2 epsilon (cPLA2-epsilon) (EC 3.1.1.4) (Calcium-dependent N-acyltransferase) (Phospholipase A2 group IVE)	PLA2G4E	Homo sapiens (Human)	868	FUNCTION: Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain (PubMed:29447909). Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to generate N-acyl phosphatidylethanolamine (NAPE). Similarly can use plasmenylethanolamine as a fatty acyl acceptor to form N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt can serve as precursors of bioactive NAEs like N-arachidonoyl phosphatidylethanolamine also called anandamide (PubMed:29447909, PubMed:30517655). Has weak phospholipase A2 and lysophospholipase activities (By similarity). Regulates intracellular membrane trafficking that requires modulation of membrane curvature as it occurs by enrichment in lysophospholipids. Promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling (By similarity). {ECO:0000250|UniProtKB:Q50L42, ECO:0000269|PubMed:29447909, ECO:0000269|PubMed:30517655}.		glycerophospholipid catabolic process [GO:0046475]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; positive regulation of endocytic recycling [GO:2001137]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; N-acyltransferase activity [GO:0016410]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; phospholipase A1 activity [GO:0008970]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; N-acyltransferase activity [GO:0016410]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; phospholipase A1 activity [GO:0008970]; glycerophospholipid catabolic process [GO:0046475]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; positive regulation of endocytic recycling [GO:2001137]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q50L42}. Early endosome membrane {ECO:0000250|UniProtKB:Q50L42}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q50L42}; Cytoplasmic side {ECO:0000250|UniProtKB:Q50L42}. Lysosome membrane {ECO:0000250|UniProtKB:Q50L42}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q50L42}; Cytoplasmic side {ECO:0000250|UniProtKB:Q50L42}. Cell membrane {ECO:0000250|UniProtKB:Q50L42}; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q50L42}. Note=Targeted to clathrin-independent endocytotic vesicles through binding to phosphoinositides, especially phosphatidylinositol 4,5-bisphosphates. {ECO:0000250|UniProtKB:Q50L42}.
Q3MJ62	reviewed	ZSC23_HUMAN	Zinc finger and SCAN domain-containing protein 23 (Zinc finger protein 390) (Zinc finger protein 453)	ZSCAN23 ZNF390 ZNF453	Homo sapiens (Human)	389	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q3MUY2	reviewed	PIGY_HUMAN	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y (Phosphatidylinositol-glycan biosynthesis class Y protein) (PIG-Y)	PIGY	Homo sapiens (Human)	71	FUNCTION: Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis (PubMed:16162815). May act by regulating the catalytic subunit PIGA (PubMed:16162815). {ECO:0000269|PubMed:16162815}.	MISCELLANEOUS: PREY and PIGY, 2 apparently unrelated proteins, are respectively the product of an upstream and a downstream ORF contained in a single bicistronic transcript.	GPI anchor biosynthetic process [GO:0006506]	endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; plasma membrane [GO:0005886]		endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; plasma membrane [GO:0005886]; GPI anchor biosynthetic process [GO:0006506]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16162815}; Multi-pass membrane protein {ECO:0000269|PubMed:16162815}.
Q3SXM5	reviewed	HSDL1_HUMAN	Inactive hydroxysteroid dehydrogenase-like protein 1 (Short chain dehydrogenase/reductase family 12C member 3)	HSDL1 SDR12C3	Homo sapiens (Human)	330				intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]		intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19026618}.
Q3SXP7	reviewed	SHSL1_HUMAN	Protein shisa-like-1	SHISAL1 KIAA1644	Homo sapiens (Human)	199				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q3SXR2	reviewed	CC036_HUMAN	Uncharacterized protein C3orf36	C3orf36	Homo sapiens (Human)	165							
Q3SXY7	reviewed	LRIT3_HUMAN	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	LRIT3	Homo sapiens (Human)	679	FUNCTION: Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (By similarity). Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina (PubMed:28334377). Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (By similarity). Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (By similarity). May also have a role in cone synapse formation (By similarity). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (PubMed:22673519). Could be a regulator of the FGFRs (PubMed:22673519). {ECO:0000250|UniProtKB:W8DXL4, ECO:0000269|PubMed:22673519, ECO:0000269|PubMed:28334377}.		regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; perikaryon [GO:0043204]		dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; perikaryon [GO:0043204]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000269|PubMed:23246293}. Perikaryon {ECO:0000250|UniProtKB:W8DXL4}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Punctate expression at dendrite tips. {ECO:0000269|PubMed:23246293}.
Q3SXY8	reviewed	AR13B_HUMAN	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1)	ARL13B ARL2L1	Homo sapiens (Human)	428	FUNCTION: Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidence is required to confirm these data. {ECO:0000269|PubMed:23150559}.	MISCELLANEOUS: Used as a ciliary marker because of its specific localization to microtubule doublets of the ciliary axoneme.	cilium assembly [GO:0060271]; dorsal/ventral pattern formation [GO:0009953]; formation of radial glial scaffolds [GO:0021943]; heart looping [GO:0001947]; interneuron migration from the subpallium to the cortex [GO:0021830]; left/right axis specification [GO:0070986]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; receptor localization to non-motile cilium [GO:0097500]; smoothened signaling pathway [GO:0007224]	axoneme [GO:0005930]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	axoneme [GO:0005930]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cilium assembly [GO:0060271]; dorsal/ventral pattern formation [GO:0009953]; formation of radial glial scaffolds [GO:0021943]; heart looping [GO:0001947]; interneuron migration from the subpallium to the cortex [GO:0021830]; left/right axis specification [GO:0070986]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; receptor localization to non-motile cilium [GO:0097500]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:18554500, ECO:0000269|PubMed:24120134}; Lipid-anchor {ECO:0000269|PubMed:18554500, ECO:0000269|PubMed:24120134}. Cell projection, cilium {ECO:0000269|PubMed:25138100}. Note=Associates to the cilium membrane via palmitoylation. Localizes to proximal ciliary membranes, to an inversin-like subciliary membrane compartment, excluding the transition zone.
Q3SXZ7	reviewed	TTLL9_HUMAN	Probable tubulin polyglutamylase TTLL9 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 9)	TTLL9 C20orf125	Homo sapiens (Human)	439	FUNCTION: Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins. Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity. Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern. {ECO:0000250|UniProtKB:A2APC3}.		flagellated sperm motility [GO:0030317]; microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; motile cilium [GO:0031514]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; motile cilium [GO:0031514]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]; flagellated sperm motility [GO:0030317]; microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A2APC3}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A2APC3}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A2APC3}.
Q3SY00	reviewed	T10IP_HUMAN	Testis-specific protein 10-interacting protein (Tsga10-interacting protein)	TSGA10IP	Homo sapiens (Human)	556			cilium organization [GO:0044782]	photoreceptor connecting cilium [GO:0032391]		photoreceptor connecting cilium [GO:0032391]; cilium organization [GO:0044782]	
Q3SY46	reviewed	KR133_HUMAN	Keratin-associated protein 13-3	KRTAP13-3 KAP13.3	Homo sapiens (Human)	172	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3SY56	reviewed	SP6_HUMAN	Transcription factor Sp6 (Krueppel-like factor 14)	SP6 KLF14	Homo sapiens (Human)	376	FUNCTION: Promotes cell proliferation (By similarity). Plays a role in tooth germ growth (By similarity). Plays a role in the control of enamel mineralization. Binds the AMBN promoter (PubMed:32167558). {ECO:0000250|UniProtKB:Q9ESX2, ECO:0000269|PubMed:32167558}.		epithelial to mesenchymal transition [GO:0001837]; odontogenesis [GO:0042476]; regulation of odontogenesis [GO:0042481]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; epithelial to mesenchymal transition [GO:0001837]; odontogenesis [GO:0042476]; regulation of odontogenesis [GO:0042481]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q3SY69	reviewed	AL1L2_HUMAN	Mitochondrial 10-formyltetrahydrofolate dehydrogenase (Mitochondrial 10-FTHFDH) (mtFDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L2)	ALDH1L2	Homo sapiens (Human)	923	FUNCTION: Mitochondrial 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide. {ECO:0000269|PubMed:21238436}.		10-formyltetrahydrofolate catabolic process [GO:0009258]; biosynthetic process [GO:0009058]; fatty acid beta-oxidation [GO:0006635]; folic acid metabolic process [GO:0046655]; NADPH regeneration [GO:0006740]; one-carbon metabolic process [GO:0006730]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	aldehyde dehydrogenase (NAD+) activity [GO:0004029]; formyltetrahydrofolate dehydrogenase activity [GO:0016155]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; formyltetrahydrofolate dehydrogenase activity [GO:0016155]; 10-formyltetrahydrofolate catabolic process [GO:0009258]; biosynthetic process [GO:0009058]; fatty acid beta-oxidation [GO:0006635]; folic acid metabolic process [GO:0046655]; NADPH regeneration [GO:0006740]; one-carbon metabolic process [GO:0006730]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20498374}.
Q3SY84	reviewed	K2C71_HUMAN	Keratin, type II cytoskeletal 71 (Cytokeratin-71) (CK-71) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (Keratin 6 irs) (hK6irs) (hK6irs1) (Type-II keratin Kb34)	KRT71 K6IRS1 KB34 KRT6IRS1	Homo sapiens (Human)	523	FUNCTION: Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. {ECO:0000269|PubMed:22592156}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22592156}.
Q3SYB3	reviewed	FX4L6_HUMAN	Forkhead box protein D4-like 6 (FOXD4-like 6)	FOXD4L6	Homo sapiens (Human)	417			anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Q3SYC2	reviewed	MOGT2_HUMAN	2-acylglycerol O-acyltransferase 2 (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 2) (MGAT2) (hMGAT2) (Diacylglycerol O-acyltransferase candidate 5) (hDC5) (Diacylglycerol acyltransferase 2-like protein 5) (Monoacylglycerol O-acyltransferase 2)	MOGAT2 DC5 DGAT2L5	Homo sapiens (Human)	334	FUNCTION: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000269|PubMed:12621063, ECO:0000269|PubMed:27184406, ECO:0000269|PubMed:28420705}.		diacylglycerol biosynthetic process [GO:0006651]; glycerol metabolic process [GO:0006071]; intestinal absorption [GO:0050892]; monoacylglycerol biosynthetic process [GO:0006640]; triglyceride biosynthetic process [GO:0019432]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear endoplasmic reticulum membrane [GO:1990578]	2-acylglycerol O-acyltransferase activity [GO:0003846]; acetyltransferase activity [GO:0016407]; diacylglycerol O-acyltransferase activity [GO:0004144]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear endoplasmic reticulum membrane [GO:1990578]; 2-acylglycerol O-acyltransferase activity [GO:0003846]; acetyltransferase activity [GO:0016407]; diacylglycerol O-acyltransferase activity [GO:0004144]; diacylglycerol biosynthetic process [GO:0006651]; glycerol metabolic process [GO:0006071]; intestinal absorption [GO:0050892]; monoacylglycerol biosynthetic process [GO:0006640]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12621063, ECO:0000269|PubMed:27184406}; Multi-pass membrane protein {ECO:0000269|PubMed:12621063}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27184406}.
Q3SYF9	reviewed	KR197_HUMAN	Keratin-associated protein 19-7	KRTAP19-7 KAP19.7	Homo sapiens (Human)	63	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3SYG4	reviewed	PTHB1_HUMAN	Protein PTHB1 (Bardet-Biedl syndrome 9 protein) (Parathyroid hormone-responsive B1 gene protein)	BBS9 PTHB1	Homo sapiens (Human)	887	FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.		cilium assembly [GO:0060271]; fat cell differentiation [GO:0045444]; protein localization to cilium [GO:0061512]; protein transport [GO:0015031]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; membrane [GO:0016020]; pericentriolar material [GO:0000242]		BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; membrane [GO:0016020]; pericentriolar material [GO:0000242]; cilium assembly [GO:0060271]; fat cell differentiation [GO:0045444]; protein localization to cilium [GO:0061512]; protein transport [GO:0015031]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Q3T906	reviewed	GNPTA_HUMAN	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC 2.7.8.17) (GlcNAc-1-phosphotransferase subunits alpha/beta) (Stealth protein GNPTAB) (UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) [Cleaved into: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta]	GNPTAB GNPTA KIAA1208	Homo sapiens (Human)	1256	FUNCTION: Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. {ECO:0000269|PubMed:19955174, ECO:0000269|PubMed:23733939, ECO:0000269|PubMed:28918368}.	MISCELLANEOUS: Due to the low pH in the endosomal/prelysosomal compartment, the lysosomal enzyme-MPR complex dissociates and then the enzyme is delivered to the lysosome. Between 5% and 20% of newly synthesized lysosomal enzymes escape the binding to the MPR in the Golgi apparatus and are secreted.; MISCELLANEOUS: Stealth proteins are part of a protein family that is conserved from bacteria to higher eukaryotes. Family members were first identified in microbes as proteins that help pathogens to elude the host innate immune system. Microbial stealth proteins are most likely involved in the biosynthesis of exopolysaccharides. Stealth proteins are predicted to function as hexose-1-phosphoryltransferases.	carbohydrate phosphorylation [GO:0046835]; lysosome organization [GO:0007040]; N-glycan processing to lysosome [GO:0016256]; secretion of lysosomal enzymes [GO:0033299]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	calcium ion binding [GO:0005509]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; calcium ion binding [GO:0005509]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976]; carbohydrate phosphorylation [GO:0046835]; lysosome organization [GO:0007040]; N-glycan processing to lysosome [GO:0016256]; secretion of lysosomal enzymes [GO:0033299]	SUBCELLULAR LOCATION: [N-acetylglucosamine-1-phosphotransferase subunit alpha]: Golgi apparatus membrane {ECO:0000269|PubMed:16120602, ECO:0000269|PubMed:16200072, ECO:0000269|PubMed:21719679, ECO:0000269|PubMed:23733939, ECO:0000269|PubMed:24375680, ECO:0000269|PubMed:25788519, ECO:0000269|PubMed:28918368}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [N-acetylglucosamine-1-phosphotransferase subunit beta]: Golgi apparatus membrane {ECO:0000269|PubMed:16120602, ECO:0000269|PubMed:16200072, ECO:0000269|PubMed:21719679, ECO:0000269|PubMed:23733939, ECO:0000269|PubMed:24375680, ECO:0000269|PubMed:28918368}; Single-pass type II membrane protein {ECO:0000305}.
Q3V5L5	reviewed	MGT5B_HUMAN	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (EC 2.4.1.-) (EC 2.4.1.155) (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B) (GlcNAc-T Vb) (GNT-Vb) (hGnTVb) (Mannoside acetylglucosaminyltransferase 5B) (N-acetylglucosaminyl-transferase Vb) (N-acetylglucosaminyltransferase IX) (GNT-IX)	MGAT5B KIAA2008	Homo sapiens (Human)	792	FUNCTION: Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. {ECO:0000269|PubMed:12941944, ECO:0000269|PubMed:14617637, ECO:0000269|PubMed:14623122, ECO:0000269|PubMed:16606368, ECO:0000269|PubMed:16857188, ECO:0000269|PubMed:19846580}.		protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation via serine [GO:0018242]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity [GO:0030144]; manganese ion binding [GO:0030145]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity [GO:0030144]; manganese ion binding [GO:0030145]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation via serine [GO:0018242]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q765H6}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q765H6}.
Q3V6T2	reviewed	GRDN_HUMAN	Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)	CCDC88A APE GRDN KIAA1212	Homo sapiens (Human)	1871	FUNCTION: Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:20462955, PubMed:16139227, PubMed:19211784, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}.		activation of protein kinase activity [GO:0032147]; activation of protein kinase B activity [GO:0032148]; cell migration [GO:0016477]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; DNA replication [GO:0006260]; lamellipodium assembly [GO:0030032]; maintenance of protein location in plasma membrane [GO:0072660]; membrane organization [GO:0061024]; nervous system development [GO:0007399]; positive regulation of cilium assembly [GO:0045724]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of stress fiber assembly [GO:0051496]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell population proliferation [GO:0042127]; regulation of DNA replication [GO:0006275]; regulation of neuron projection development [GO:0010975]; regulation of protein phosphorylation [GO:0001932]; small GTPase mediated signal transduction [GO:0007264]; TOR signaling [GO:0031929]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; COPI-coated Golgi to ER transport vesicle [GO:0030142]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; membrane [GO:0016020]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; dynein light intermediate chain binding [GO:0051959]; epidermal growth factor receptor binding [GO:0005154]; G-protein alpha-subunit binding [GO:0001965]; G-protein gamma-subunit binding [GO:0031682]; GDP-dissociation inhibitor activity [GO:0005092]; guanyl-nucleotide exchange factor activity [GO:0005085]; insulin receptor binding [GO:0005158]; microtubule binding [GO:0008017]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; protein kinase B binding [GO:0043422]; protein kinase C binding [GO:0005080]; SH2 domain binding [GO:0042169]; vascular endothelial growth factor receptor 2 binding [GO:0043184]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; COPI-coated Golgi to ER transport vesicle [GO:0030142]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; membrane [GO:0016020]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; dynein light intermediate chain binding [GO:0051959]; epidermal growth factor receptor binding [GO:0005154]; G-protein alpha-subunit binding [GO:0001965]; G-protein gamma-subunit binding [GO:0031682]; GDP-dissociation inhibitor activity [GO:0005092]; guanyl-nucleotide exchange factor activity [GO:0005085]; insulin receptor binding [GO:0005158]; microtubule binding [GO:0008017]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; protein kinase B binding [GO:0043422]; protein kinase C binding [GO:0005080]; SH2 domain binding [GO:0042169]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; activation of protein kinase activity [GO:0032147]; activation of protein kinase B activity [GO:0032148]; cell migration [GO:0016477]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; DNA replication [GO:0006260]; lamellipodium assembly [GO:0030032]; maintenance of protein location in plasma membrane [GO:0072660]; membrane organization [GO:0061024]; nervous system development [GO:0007399]; positive regulation of cilium assembly [GO:0045724]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of stress fiber assembly [GO:0051496]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell population proliferation [GO:0042127]; regulation of DNA replication [GO:0006275]; regulation of neuron projection development [GO:0010975]; regulation of protein phosphorylation [GO:0001932]; small GTPase mediated signal transduction [GO:0007264]; TOR signaling [GO:0031929]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:27864364}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:27864364}. Cytoplasmic vesicle {ECO:0000269|PubMed:15749703, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}. Cell projection, lamellipodium {ECO:0000269|PubMed:15882442}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27623382}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:27623382}. Note=Localizes to the cytosol in unstimulated cells while EGF stimulation promotes membrane localization and guanine nucleotide exchange factor activity (PubMed:27864364). Localizes to the cell membrane through interaction with phosphoinositides (PubMed:16139227, PubMed:15882442). {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:27864364}.
Q3YBM2	reviewed	T176B_HUMAN	Transmembrane protein 176B (Protein LR8)	TMEM176B LR8	Homo sapiens (Human)	270	FUNCTION: May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). {ECO:0000250}.		animal organ morphogenesis [GO:0009887]; dendritic cell differentiation [GO:0097028]; negative regulation of dendritic cell differentiation [GO:2001199]	nuclear membrane [GO:0031965]		nuclear membrane [GO:0031965]; animal organ morphogenesis [GO:0009887]; dendritic cell differentiation [GO:0097028]; negative regulation of dendritic cell differentiation [GO:2001199]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q3YBR2	reviewed	TBRG1_HUMAN	Transforming growth factor beta regulator 1 (Nuclear interactor of ARF and Mdm2)	TBRG1 NIAM	Homo sapiens (Human)	411	FUNCTION: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. {ECO:0000269|PubMed:17110379}.		cell cycle [GO:0007049]; DNA replication [GO:0006260]; negative regulation of cell population proliferation [GO:0008285]; protein localization to nucleoplasm [GO:1990173]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell cycle [GO:0007049]; DNA replication [GO:0006260]; negative regulation of cell population proliferation [GO:0008285]; protein localization to nucleoplasm [GO:1990173]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17110379}.
Q3YEC7	reviewed	RABL6_HUMAN	Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1)	RABL6 C9orf86 PARF	Homo sapiens (Human)	729	FUNCTION: May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. {ECO:0000269|PubMed:16582619}.	MISCELLANEOUS: [Isoform 1]: Predominant isoform. Overexpressed in about 67% of primary breast tumors.		centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:17962191}. Note=Predominantly cytoplasmic (PubMed:17962191).; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:17962191}. Note=Predominantly nuclear (PubMed:17962191).
Q3ZAQ7	reviewed	VMA21_HUMAN	Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein)	VMA21 MEAX XMEA	Homo sapiens (Human)	101	FUNCTION: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. {ECO:0000255|HAMAP-Rule:MF_03058, ECO:0000269|PubMed:19379691}.		regulation of ATP-dependent activity [GO:0043462]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; lysosome [GO:0005764]		endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; lysosome [GO:0005764]; regulation of ATP-dependent activity [GO:0043462]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03058, ECO:0000269|PubMed:19379691, ECO:0000269|PubMed:23315026}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03058}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000255|HAMAP-Rule:MF_03058, ECO:0000269|PubMed:19379691, ECO:0000269|PubMed:23315026}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03058}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000255|HAMAP-Rule:MF_03058, ECO:0000269|PubMed:19379691, ECO:0000269|PubMed:23315026}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03058}.
Q3ZCM7	reviewed	TBB8_HUMAN	Tubulin beta-8 chain (Tubulin beta 8 class VIII)	TUBB8	Homo sapiens (Human)	444	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}.		microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; oocyte maturation [GO:0001556]; spindle assembly involved in female meiosis [GO:0007056]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; meiotic spindle [GO:0072687]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; meiotic spindle [GO:0072687]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; oocyte maturation [GO:0001556]; spindle assembly involved in female meiosis [GO:0007056]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26789871}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26789871}.
Q3ZCQ8	reviewed	TIM50_HUMAN	Mitochondrial import inner membrane translocase subunit TIM50	TIMM50 TIM50 PRO1512	Homo sapiens (Human)	353	FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. {ECO:0000269|PubMed:15044455}.; FUNCTION: [Isoform 2]: May participate in the release of snRNPs and SMN from the Cajal body. {ECO:0000269|PubMed:16008839}.		intracellular protein transport [GO:0006886]; mitochondrial membrane organization [GO:0007006]; protein dephosphorylation [GO:0006470]; protein import into mitochondrial matrix [GO:0030150]; release of cytochrome c from mitochondria [GO:0001836]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	interleukin-2 receptor binding [GO:0005134]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; interleukin-2 receptor binding [GO:0005134]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; intracellular protein transport [GO:0006886]; mitochondrial membrane organization [GO:0007006]; protein dephosphorylation [GO:0006470]; protein import into mitochondrial matrix [GO:0030150]; release of cytochrome c from mitochondria [GO:0001836]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:15044455}; Single-pass membrane protein {ECO:0000269|PubMed:15044455}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus speckle {ECO:0000269|PubMed:16008839}. Note=Nuclear and enriched in speckles with snRNPs. {ECO:0000269|PubMed:16008839}.
Q401N2	reviewed	ZACN_HUMAN	Zinc-activated ligand-gated ion channel (Ligand-gated ion channel zinc-activated 1) (Ligand-gated ion-channel receptor L2)	ZACN L2 LGICZ LGICZ1 ZAC	Homo sapiens (Human)	412	FUNCTION: Zinc-activated ligand-gated ion channel. {ECO:0000269|PubMed:12381728}.	MISCELLANEOUS: The mouse and rat orthologous proteins do not exist.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	monoatomic ion transmembrane transport [GO:0034220]; response to zinc ion [GO:0010043]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synapse [GO:0045202]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]; transmembrane signaling receptor activity [GO:0004888]; zinc ion binding [GO:0008270]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synapse [GO:0045202]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]; transmembrane signaling receptor activity [GO:0004888]; zinc ion binding [GO:0008270]; monoatomic ion transmembrane transport [GO:0034220]; response to zinc ion [GO:0010043]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16083862}; Multi-pass membrane protein {ECO:0000269|PubMed:16083862}.
Q460N3	reviewed	PAR15_HUMAN	Protein mono-ADP-ribosyltransferase PARP15 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) (Poly [ADP-ribose] polymerase 15) (PARP-15)	PARP15 BAL3	Homo sapiens (Human)	678	FUNCTION: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:16061477, PubMed:25043379, PubMed:25635049). Acts as a negative regulator of transcription (PubMed:16061477). {ECO:0000269|PubMed:16061477, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:25635049}.		negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein poly-ADP-ribosylation [GO:0070212]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; transcription corepressor activity [GO:0003714]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein poly-ADP-ribosylation [GO:0070212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:16061477}.
Q460N5	reviewed	PAR14_HUMAN	Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14)	PARP14 BAL2 KIAA1268	Homo sapiens (Human)	1801	FUNCTION: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:27796300, PubMed:18851833, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300). {ECO:0000269|PubMed:16061477, ECO:0000269|PubMed:18851833, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:27796300, ECO:0000305|PubMed:29858569}.		innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein poly-ADP-ribosylation [GO:0070212]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; transcription corepressor activity [GO:0003714]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein poly-ADP-ribosylation [GO:0070212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2EMV9}. Cytoplasm {ECO:0000269|PubMed:27796300}. Note=In steady state splenocytes the protein is mostly nuclear (By similarity). A minor proportion is detected in the cytoplasm (By similarity). In macrophages, mainly localizes to the cytoplasm (PubMed:27796300). {ECO:0000250|UniProtKB:Q2EMV9, ECO:0000269|PubMed:27796300}.
Q494R4	reviewed	CC153_HUMAN	Coiled-coil domain-containing protein 153	CCDC153	Homo sapiens (Human)	210					identical protein binding [GO:0042802]	identical protein binding [GO:0042802]	
Q494U1	reviewed	PKHN1_HUMAN	Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)	PLEKHN1 CLPABP	Homo sapiens (Human)	611	FUNCTION: Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1 (PubMed:29180010). Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS) (PubMed:18191643). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells (PubMed:29531808) (By similarity). {ECO:0000250|UniProtKB:Q8C886, ECO:0000269|PubMed:18191643, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:29531808}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; positive regulation of apoptotic process [GO:0043065]; response to hypoxia [GO:0001666]	cytoskeleton [GO:0005856]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylserine binding [GO:0001786]	cytoskeleton [GO:0005856]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylserine binding [GO:0001786]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; positive regulation of apoptotic process [GO:0043065]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25043870}; Lipid-anchor {ECO:0000269|PubMed:25043870}. Mitochondrion {ECO:0000269|PubMed:27616329, ECO:0000269|PubMed:29531808}. Mitochondrion membrane {ECO:0000269|PubMed:18191643, ECO:0000269|PubMed:29180010}. Note=Interaction with C1QBP and phosphorylation is essential for its mitochondrial localization. Localizes on the microtubule in the form of small granules. {ECO:0000269|PubMed:18191643}.
Q494V2	reviewed	CP100_HUMAN	Cilia- and flagella-associated protein 100 (Coiled-coil domain-containing protein 37)	CFAP100 CCDC37	Homo sapiens (Human)	611	FUNCTION: May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. {ECO:0000250|UniProtKB:A8I4E9}.		cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]	axonemal outer doublet [GO:0097545]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514]	dynein complex binding [GO:0070840]	axonemal outer doublet [GO:0097545]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514]; dynein complex binding [GO:0070840]; cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A8I4E9}.
Q495A1	reviewed	TIGIT_HUMAN	T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)	TIGIT VSIG9 VSTM3	Homo sapiens (Human)	244	FUNCTION: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. {ECO:0000269|PubMed:19011627}.		negative regulation of interleukin-12 production [GO:0032695]; negative regulation of T cell activation [GO:0050868]; positive regulation of interleukin-10 production [GO:0032733]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of T cell activation [GO:0050868]; positive regulation of interleukin-10 production [GO:0032733]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19011627}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011627}.
Q495C1	reviewed	RN212_HUMAN	Probable E3 SUMO-protein ligase RNF212 (EC 2.3.2.-) (Probable E3 SUMO-protein transferase RNF212) (RING finger protein 212)	RNF212	Homo sapiens (Human)	297	FUNCTION: SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity). {ECO:0000250}.		chiasma assembly [GO:0051026]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic gene conversion [GO:0006311]; protein sumoylation [GO:0016925]; reciprocal meiotic recombination [GO:0007131]	synaptonemal complex [GO:0000795]	metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789]	synaptonemal complex [GO:0000795]; metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789]; chiasma assembly [GO:0051026]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic gene conversion [GO:0006311]; protein sumoylation [GO:0016925]; reciprocal meiotic recombination [GO:0007131]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity). {ECO:0000250}.
Q495M3	reviewed	S36A2_HUMAN	Proton-coupled amino acid transporter 2 (Proton/amino acid transporter 2) (Solute carrier family 36 member 2) (Transmembrane domain rich protein 1) (Tramdorin-1)	SLC36A2 PAT2 TRAMD1	Homo sapiens (Human)	483	FUNCTION: Electrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N-dimethylglycine, are also tolerated but decrease transport efficiency. A free carboxyl group is preferred. {ECO:0000269|PubMed:12809675, ECO:0000269|PubMed:19033659}.		amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine transport [GO:0015808]; monoatomic ion transport [GO:0006811]; proline transmembrane transport [GO:0035524]; proline transport [GO:0015824]; proton transmembrane transport [GO:1902600]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; vacuolar membrane [GO:0005774]	amino acid transmembrane transporter activity [GO:0015171]; amino acid:proton symporter activity [GO:0005280]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; proline:proton symporter activity [GO:0005297]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; vacuolar membrane [GO:0005774]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:proton symporter activity [GO:0005280]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; proline:proton symporter activity [GO:0005297]; amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine transport [GO:0015808]; monoatomic ion transport [GO:0006811]; proline transmembrane transport [GO:0035524]; proline transport [GO:0015824]; proton transmembrane transport [GO:1902600]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19033659}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BHK3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8BHK3}.
Q495M9	reviewed	USH1G_HUMAN	pre-mRNA splicing regulator USH1G (Scaffold protein containing ankyrin repeats and SAM domain) (Usher syndrome type-1G protein)	USH1G SANS	Homo sapiens (Human)	461	FUNCTION: Plays a role in pre-mRNA splicing by regulating the release and transfer of U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complexes from their assembly site in Cajal bodies to nuclear speckles, thereby contributing to the assembly of the pre-catalytic spliceosome on target pre-mRNAs (PubMed:34023904). May also participate in recycling of snRNPs back to Cajal bodies during splicing (PubMed:34023904). Plays a role in regulating MAGI2-mediated endocytosis (PubMed:24608321). Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. Required for normal hearing. {ECO:0000269|PubMed:21709241, ECO:0000269|PubMed:24608321, ECO:0000269|PubMed:34023904}.		equilibrioception [GO:0050957]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell stereocilium organization [GO:0060122]; photoreceptor cell maintenance [GO:0045494]; regulation of clathrin-dependent endocytosis [GO:2000369]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	actin cytoskeleton [GO:0015629]; Cajal body [GO:0015030]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; photoreceptor cell cilium [GO:0097733]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; spectrin binding [GO:0030507]	actin cytoskeleton [GO:0015629]; Cajal body [GO:0015030]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; photoreceptor cell cilium [GO:0097733]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; spectrin binding [GO:0030507]; equilibrioception [GO:0050957]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell stereocilium organization [GO:0060122]; photoreceptor cell maintenance [GO:0045494]; regulation of clathrin-dependent endocytosis [GO:2000369]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250|UniProtKB:Q80T11}; Peripheral membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80T11}. Nucleus speckle {ECO:0000269|PubMed:34023904}. Nucleus, Cajal body {ECO:0000269|PubMed:34023904}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q80T11}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q80T11}. Note=Detected at the tip of cochlear hair cell stereocilia. Recruited to the cell membrane via interaction with CDH23 or PCDH15 (By similarity). In photoreceptor cilia, detected predominantly at the cilium base (By similarity). Expressed in the pericentriolar region of the centrosome (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q80T11}.
Q495T6	reviewed	MMEL1_HUMAN	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]	MMEL1 MELL1 MMEL2 NEP2	Homo sapiens (Human)	779	FUNCTION: Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). {ECO:0000250}.		protein processing [GO:0016485]; proteolysis [GO:0006508]	extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]	endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; protein processing [GO:0016485]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteolytic cleavage also exists. {ECO:0000250}.
Q495W5	reviewed	FUT11_HUMAN	Alpha-(1,3)-fucosyltransferase 11 (EC 2.4.1.-) (Fucosyltransferase XI) (Fuc-TXI) (FucT-XI) (Galactoside 3-L-fucosyltransferase 11) (Fucosyltransferase 11)	FUT11	Homo sapiens (Human)	492	FUNCTION: [Isoform 1]: Has minor fucosyltransferase activity toward biantennary N-glycan acceptors. Does not fucosylate GlcNAc residue within type 2 lactosamine unit. {ECO:0000269|PubMed:19088067}.; FUNCTION: [Isoform 2]: Has fucosyltransferase activity toward biantennary N-glycan acceptors. Does not fucosylate GlcNAc residue within type 2 lactosamine unit. {ECO:0000269|PubMed:19088067}.		fucosylation [GO:0036065]; N-glycan fucosylation [GO:0036071]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]; fucosylation [GO:0036065]; N-glycan fucosylation [GO:0036071]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q496A3	reviewed	SPAS1_HUMAN	Spermatogenesis-associated serine-rich protein 1	SPATS1	Homo sapiens (Human)	300		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q496F6	reviewed	CLM2_HUMAN	CMRF35-like molecule 2 (CLM-2) (CD300 antigen-like family member E) (CMRF35-A5) (Immune receptor expressed on myeloid cells 2) (IREM-2) (Polymeric immunoglobulin receptor 2) (PIgR-2) (PIgR2) (Poly-Ig receptor 2) (CD antigen CD300e)	CD300E CD300LE CLM2 CMRF35A5 IREM2	Homo sapiens (Human)	205	FUNCTION: Probably acts as an activating receptor. {ECO:0000269|PubMed:15557162}.		immune system process [GO:0002376]	plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; immune system process [GO:0002376]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q496J9	reviewed	SV2C_HUMAN	Synaptic vesicle glycoprotein 2C	SV2C KIAA1054	Homo sapiens (Human)	727	FUNCTION: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. {ECO:0000250|UniProtKB:Q9Z2I6}.; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 (PubMed:27313224). Recognition by BoNT/A relies on both protein-protein and protein-N-glycosylation; glycosylation of Asn-559 increases its affinity for BoNT/A (PubMed:27313224). Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction (PubMed:29649119). {ECO:0000269|PubMed:24240280, ECO:0000269|PubMed:27294781, ECO:0000269|PubMed:27313224, ECO:0000269|PubMed:28252640, ECO:0000269|PubMed:29649119}.; FUNCTION: (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); note that type D does not usually infect humans. {ECO:0000269|PubMed:21483489}.		chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836]; regulation of synaptic vesicle exocytosis [GO:2000300]	dopaminergic synapse [GO:0098691]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	transmembrane transporter activity [GO:0022857]	dopaminergic synapse [GO:0098691]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter activity [GO:0022857]; chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836]; regulation of synaptic vesicle exocytosis [GO:2000300]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9Z2I6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Z2I6}. Note=Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas. {ECO:0000250|UniProtKB:Q9Z2I6}.
Q496M5	reviewed	PLK5_HUMAN	Inactive serine/threonine-protein kinase PLK5 (Polo-like kinase 5) (PLK-5)	PLK5 PLK5P FG060302	Homo sapiens (Human)	336	FUNCTION: Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation. {ECO:0000269|PubMed:21245385}.		cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cell division [GO:0051301]; cellular response to growth factor stimulus [GO:0071363]; defense response to tumor cell [GO:0002357]; positive regulation of neuron projection development [GO:0010976]; regulation of apoptotic process [GO:0042981]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cell division [GO:0051301]; cellular response to growth factor stimulus [GO:0071363]; defense response to tumor cell [GO:0002357]; positive regulation of neuron projection development [GO:0010976]; regulation of apoptotic process [GO:0042981]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:21245385}.
Q49A17	reviewed	GLTL6_HUMAN	Polypeptide N-acetylgalactosaminyltransferase-like 6 (EC 2.4.1.41) (Polypeptide GalNAc transferase 17) (GalNAc-T17) (pp-GaNTase 17) (Protein-UDP acetylgalactosaminyltransferase 17) (Putative polypeptide N-acetylgalactosaminyltransferase 17) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17)	GALNTL6 GALNT17	Homo sapiens (Human)	601	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. {ECO:0000250}.		protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via threonine [GO:0018243]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via threonine [GO:0018243]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q49A26	reviewed	GLYR1_HUMAN	Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1)	GLYR1 HIBDL NDF NP60 NPAC	Homo sapiens (Human)	553	FUNCTION: Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:30970244, PubMed:29759984). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:30970244, PubMed:29759984). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}.		transcription elongation-coupled chromatin remodeling [GO:0140673]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]	chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; DNA binding [GO:0003677]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; nucleosome binding [GO:0031491]; oxidoreductase activity [GO:0016491]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; DNA binding [GO:0003677]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; nucleosome binding [GO:0031491]; oxidoreductase activity [GO:0016491]; transcription elongation-coupled chromatin remodeling [GO:0140673]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16352664}. Chromosome {ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244}. Note=Found in actively RNAPolII-transcribed gene bodies. {ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:31408337}.
Q49A88	reviewed	CCD14_HUMAN	Coiled-coil domain-containing protein 14	CCDC14	Homo sapiens (Human)	953	FUNCTION: Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}.		protein localization to centrosome [GO:0071539]; substantia nigra development [GO:0021762]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]		centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; protein localization to centrosome [GO:0071539]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. Note=Colocalizes with PCM1 at centriolar satellites throughout the cell cycle. {ECO:0000269|PubMed:26297806}.
Q49AJ0	reviewed	F135B_HUMAN	Protein FAM135B	FAM135B C8orfK32	Homo sapiens (Human)	1406			cellular lipid metabolic process [GO:0044255]			cellular lipid metabolic process [GO:0044255]	
Q49AM1	reviewed	MTEF2_HUMAN	Transcription termination factor 2, mitochondrial (Mitochondrial transcription termination factor 2) (mTERF2) (Mitochondrial transcription termination factor-like protein) (mTERF-like) (mTERFL) (mTERF domain-containing protein 3, mitochondrial)	MTERF2 MTERFD3	Homo sapiens (Human)	385	FUNCTION: Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species. {ECO:0000269|PubMed:16226716, ECO:0000269|PubMed:19366608, ECO:0000269|PubMed:21558281}.		regulation of DNA-templated transcription [GO:0006355]; termination of mitochondrial transcription [GO:0006393]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; nucleic acid binding [GO:0003676]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; nucleic acid binding [GO:0003676]; regulation of DNA-templated transcription [GO:0006355]; termination of mitochondrial transcription [GO:0006393]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16226716}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q8BKY8}.
Q49AN0	reviewed	CRY2_HUMAN	Cryptochrome-2	CRY2 KIAA0658	Homo sapiens (Human)	593	FUNCTION: Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. May mediate circadian regulation of cAMP signaling and gluconeogenesis by blocking glucagon-mediated increases in intracellular cAMP concentrations and in CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-BMAL1 induced transcription of NAMPT (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Represses the transcriptional activity of NR1I2 (By similarity). {ECO:0000250|UniProtKB:Q9R194, ECO:0000269|PubMed:10531061, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:16790549}.		blue light signaling pathway [GO:0009785]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; glucose homeostasis [GO:0042593]; lipid storage [GO:0019915]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of glucocorticoid secretion [GO:2000850]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein import into nucleus [GO:0006606]; regulation of circadian rhythm [GO:0042752]; regulation of sodium-dependent phosphate transport [GO:2000118]; response to activity [GO:0014823]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	blue light photoreceptor activity [GO:0009882]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; FAD binding [GO:0071949]; nuclear receptor binding [GO:0016922]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; single-stranded DNA binding [GO:0003697]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; blue light photoreceptor activity [GO:0009882]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; FAD binding [GO:0071949]; nuclear receptor binding [GO:0016922]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; single-stranded DNA binding [GO:0003697]; transcription cis-regulatory region binding [GO:0000976]; blue light signaling pathway [GO:0009785]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; glucose homeostasis [GO:0042593]; lipid storage [GO:0019915]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of glucocorticoid secretion [GO:2000850]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein import into nucleus [GO:0006606]; regulation of circadian rhythm [GO:0042752]; regulation of sodium-dependent phosphate transport [GO:2000118]; response to activity [GO:0014823]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9801304}. Nucleus {ECO:0000269|PubMed:22798407, ECO:0000269|PubMed:9801304}. Note=Translocated to the nucleus through interaction with other Clock proteins such as PER2 or BMAL1.
Q49MG5	reviewed	MAP9_HUMAN	Microtubule-associated protein 9 (Aster-associated protein)	MAP9 ASAP	Homo sapiens (Human)	647	FUNCTION: Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules. {ECO:0000269|PubMed:16049101}.		mitotic cytokinesis [GO:0000281]; mitotic spindle assembly [GO:0090307]; regulation of mitotic centrosome separation [GO:0046602]; regulation of mitotic cytokinesis [GO:1902412]; regulation of mitotic spindle organization [GO:0060236]	astral microtubule [GO:0000235]; axon [GO:0030424]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; mitotic spindle midzone [GO:1990023]; spindle midzone [GO:0051233]	microtubule binding [GO:0008017]	astral microtubule [GO:0000235]; axon [GO:0030424]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; mitotic spindle midzone [GO:1990023]; spindle midzone [GO:0051233]; microtubule binding [GO:0008017]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly [GO:0090307]; regulation of mitotic centrosome separation [GO:0046602]; regulation of mitotic cytokinesis [GO:1902412]; regulation of mitotic spindle organization [GO:0060236]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16049101}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16049101}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16049101}. Note=Localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body during cytokinesis.
Q49MI3	reviewed	CERKL_HUMAN	Ceramide kinase-like protein	CERKL	Homo sapiens (Human)	558	FUNCTION: Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. {ECO:0000269|PubMed:15708351, ECO:0000269|PubMed:19158957}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	negative regulation of apoptotic process [GO:0043066]; phosphorylation [GO:0016310]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid metabolic process [GO:0006665]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	lipid kinase activity [GO:0001727]; sphingolipid binding [GO:0046625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; lipid kinase activity [GO:0001727]; sphingolipid binding [GO:0046625]; negative regulation of apoptotic process [GO:0043066]; phosphorylation [GO:0016310]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid metabolic process [GO:0006665]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Note=Enriched in nucleoli. May shuttle between nucleus and cytoplasm. Isoform 5 is not enriched in the nucleoli.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus, nucleolus. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum.
Q4AC94	reviewed	C2CD3_HUMAN	C2 domain-containing protein 3	C2CD3	Homo sapiens (Human)	2353	FUNCTION: Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}.		brain development [GO:0007420]; centriole elongation [GO:0061511]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; neural plate axis specification [GO:0021997]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; protein localization to centrosome [GO:0071539]; protein processing [GO:0016485]; regulation of proteolysis [GO:0030162]; regulation of smoothened signaling pathway [GO:0008589]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]		centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; brain development [GO:0007420]; centriole elongation [GO:0061511]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; neural plate axis specification [GO:0021997]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; protein localization to centrosome [GO:0071539]; protein processing [GO:0016485]; regulation of proteolysis [GO:0030162]; regulation of smoothened signaling pathway [GO:0008589]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. Note=Localizes to centrioles and procentrioles both in interphase and mitosis. Localizes to centriolar satellites, localization is dependent on PCM1 and dynein-mediated retrograde transport. Also localizes to the distal ends of the mother and daughter centrioles.
Q4ADV7	reviewed	RIC1_HUMAN	Guanine nucleotide exchange factor subunit RIC1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1)	RIC1 CIP150 KIAA1432	Homo sapiens (Human)	1423	FUNCTION: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796). {ECO:0000269|PubMed:16112082, ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:31932796}.		cranial skeletal system development [GO:1904888]; intracellular protein transport [GO:0006886]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of GTPase activity [GO:0043547]; regulation of extracellular matrix constituent secretion [GO:0003330]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; Ric1-Rgp1 guanyl-nucleotide exchange factor complex [GO:0034066]; trans-Golgi network membrane [GO:0032588]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; Ric1-Rgp1 guanyl-nucleotide exchange factor complex [GO:0034066]; trans-Golgi network membrane [GO:0032588]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; cranial skeletal system development [GO:1904888]; intracellular protein transport [GO:0006886]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of GTPase activity [GO:0043547]; regulation of extracellular matrix constituent secretion [GO:0003330]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23091056}. Membrane {ECO:0000269|PubMed:23091056}.
Q4FZB7	reviewed	KMT5B_HUMAN	Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361)	KMT5B SUV420H1 CGI-85	Homo sapiens (Human)	885	FUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q3U8K7, ECO:0000269|PubMed:23720823, ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273}.		DNA repair [GO:0006281]; methylation [GO:0032259]; muscle organ development [GO:0007517]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]	condensed chromosome, centromeric region [GO:0000779]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone H4 methyltransferase activity [GO:0140939]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]	condensed chromosome, centromeric region [GO:0000779]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone H4 methyltransferase activity [GO:0140939]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]; DNA repair [GO:0006281]; methylation [GO:0032259]; muscle organ development [GO:0007517]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23720823}. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.
Q4G0J3	reviewed	LARP7_HUMAN	La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)	LARP7 HDCMA18P	Homo sapiens (Human)	582	FUNCTION: RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18483487, PubMed:18281698). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}.		box C/D RNA 3'-end processing [GO:0000494]; cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of viral transcription [GO:0032897]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]; U6 2'-O-snRNA methylation [GO:1990438]	7SK snRNP [GO:0120259]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]	7SK snRNA binding [GO:0097322]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070]	7SK snRNP [GO:0120259]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; 7SK snRNA binding [GO:0097322]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070]; box C/D RNA 3'-end processing [GO:0000494]; cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of viral transcription [GO:0032897]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]; U6 2'-O-snRNA methylation [GO:1990438]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:18483487}.
Q4G0M1	reviewed	ERFE_HUMAN	Erythroferrone (Complement C1q tumor necrosis factor-related protein 15) (Myonectin)	ERFE C1QTNF15 CTRP15 FAM132B	Homo sapiens (Human)	354	FUNCTION: Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (PubMed:24880340, PubMed:30097509, PubMed:31800957). Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity). Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling (By similarity). Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway (By similarity). Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling (By similarity). The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption (By similarity). {ECO:0000250|UniProtKB:Q6PGN1, ECO:0000269|PubMed:24880340, ECO:0000269|PubMed:30097509, ECO:0000269|PubMed:31800957}.		establishment of localization in cell [GO:0051649]; fatty acid transport [GO:0015908]; intracellular iron ion homeostasis [GO:0006879]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of fatty acid transport [GO:2000193]; positive regulation of glucose import [GO:0046326]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of fatty acid metabolic process [GO:0019217]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	hormone activity [GO:0005179]; identical protein binding [GO:0042802]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; establishment of localization in cell [GO:0051649]; fatty acid transport [GO:0015908]; intracellular iron ion homeostasis [GO:0006879]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of fatty acid transport [GO:2000193]; positive regulation of glucose import [GO:0046326]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of fatty acid metabolic process [GO:0019217]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6PGN1}. Note=Secreted when glycosylated at Asn-243 and Asn-295 (By similarity). Hydroxylation promotes secretion (By similarity). {ECO:0000250|UniProtKB:Q6PGN1}.
Q4G0N4	reviewed	NAKD2_HUMAN	NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial)	NADK2 C5orf33 MNADK NADKD1	Homo sapiens (Human)	442	FUNCTION: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. {ECO:0000269|PubMed:23212377}.		NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741]; phosphorylation [GO:0016310]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; NAD+ kinase activity [GO:0003951]; protein homodimerization activity [GO:0042803]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; NAD+ kinase activity [GO:0003951]; protein homodimerization activity [GO:0042803]; NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23212377}.
Q4G0N8	reviewed	SL9C1_HUMAN	Sodium/hydrogen exchanger 10 (Na(+)/H(+) exchanger 10) (NHE-10) (Solute carrier family 9 member 10) (Solute carrier family 9 member C1) (Sperm-specific Na(+)/H(+) exchanger) (sNHE)	SLC9C1 SLC9A10	Homo sapiens (Human)	1177	FUNCTION: Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; spermatogenesis [GO:0007283]	motile cilium [GO:0031514]; plasma membrane [GO:0005886]	monoatomic ion channel activity [GO:0005216]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	motile cilium [GO:0031514]; plasma membrane [GO:0005886]; monoatomic ion channel activity [GO:0005216]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q4G0P3	reviewed	HYDIN_HUMAN	Hydrocephalus-inducing protein homolog	HYDIN HYDIN1 KIAA1864	Homo sapiens (Human)	5121	FUNCTION: Required for ciliary motility. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cell development [GO:0002064]; trachea development [GO:0060438]; ventricular system development [GO:0021591]	axonemal central apparatus [GO:1990716]; axonemal central pair projection [GO:1990718]; axoneme [GO:0005930]		axonemal central apparatus [GO:1990716]; axonemal central pair projection [GO:1990718]; axoneme [GO:0005930]; axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cell development [GO:0002064]; trachea development [GO:0060438]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000305}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q80W93}. Note=Localizes in the cilium axoneme in a SPEF1-dependent manner. {ECO:0000250|UniProtKB:Q80W93}.
Q4G0S4	reviewed	C27C1_HUMAN	Cytochrome P450 27C1 (EC 1.14.19.53) (All-trans retinol 3,4-desaturase)	CYP27C1	Homo sapiens (Human)	542	FUNCTION: [Isoform 2]: A cytochrome P450 monooxygenase that catalyzes the 3,4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3,4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans retinal and all-trans retinoic acid. Forms minor amounts of 3-hydroxy and 4-hydroxy all-trans-retinol derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). {ECO:0000269|PubMed:27059013, ECO:0000269|PubMed:28701464}.		retinal metabolic process [GO:0042574]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	11-cis retinal binding [GO:0005502]; 11-cis-retinal 3,4-desaturase activity [GO:0061899]; all-trans retinal 3,4-desaturase activity [GO:0061897]; all-trans retinal binding [GO:0005503]; all-trans retinoic acid 3,4-desaturase activity [GO:0061898]; all-trans retinol 3,4-desaturase activity [GO:0061896]; all-trans-retinol binding [GO:1904768]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; retinoic acid binding [GO:0001972]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; 11-cis retinal binding [GO:0005502]; 11-cis-retinal 3,4-desaturase activity [GO:0061899]; all-trans retinal 3,4-desaturase activity [GO:0061897]; all-trans retinal binding [GO:0005503]; all-trans retinoic acid 3,4-desaturase activity [GO:0061898]; all-trans retinol 3,4-desaturase activity [GO:0061896]; all-trans-retinol binding [GO:1904768]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; retinoic acid binding [GO:0001972]; retinal metabolic process [GO:0042574]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]	SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion membrane {ECO:0000250|UniProtKB:P14137}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14137}.
Q4G0U5	reviewed	PCDP1_HUMAN	Cilia- and flagella-associated protein 221 (Primary ciliary dyskinesia protein 1)	CFAP221 PCDP1	Homo sapiens (Human)	840	FUNCTION: May play a role in cilium morphogenesis. {ECO:0000250|UniProtKB:A9Q751}.		cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; establishment of localization in cell [GO:0051649]; motile cilium assembly [GO:0044458]; mucociliary clearance [GO:0120197]; sperm flagellum assembly [GO:0120316]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; manchette [GO:0002177]; sperm flagellum [GO:0036126]	calmodulin binding [GO:0005516]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; manchette [GO:0002177]; sperm flagellum [GO:0036126]; calmodulin binding [GO:0005516]; cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; establishment of localization in cell [GO:0051649]; motile cilium assembly [GO:0044458]; mucociliary clearance [GO:0120197]; sperm flagellum assembly [GO:0120316]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:18039845}. Cytoplasm {ECO:0000250|UniProtKB:A9Q751}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A9Q751}. Note=Localizes to the manchette in elongating spermatids in a SPAG17-dependent manner. {ECO:0000250|UniProtKB:A9Q751}.
Q4G0W2	reviewed	DUS28_HUMAN	Dual specificity phosphatase 28 (EC 3.1.3.16) (EC 3.1.3.48)	DUSP28	Homo sapiens (Human)	176	FUNCTION: Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro) (PubMed:24531476, PubMed:29121083). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine (PubMed:29121083). The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site (PubMed:29121083). {ECO:0000269|PubMed:24531476, ECO:0000269|PubMed:29121083}.		dephosphorylation [GO:0016311]		myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; dephosphorylation [GO:0016311]	
Q4G0X4	reviewed	KCD21_HUMAN	BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21)	KCTD21	Homo sapiens (Human)	260	FUNCTION: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). {ECO:0000269|PubMed:21472142}.		negative regulation of smoothened signaling pathway [GO:0045879]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]		cullin family protein binding [GO:0097602]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]	cullin family protein binding [GO:0097602]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; negative regulation of smoothened signaling pathway [GO:0045879]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q4G0X9	reviewed	CCD40_HUMAN	Coiled-coil domain-containing protein 40	CCDC40 KIAA1640	Homo sapiens (Human)	1142	FUNCTION: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131974). Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (PubMed:21131974). {ECO:0000250|UniProtKB:A8IQT2, ECO:0000269|PubMed:21131974}.		axonemal dynein complex assembly [GO:0070286]; axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; regulation of cilium beat frequency [GO:0003356]	axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]		axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; axonemal dynein complex assembly [GO:0070286]; axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; regulation of cilium beat frequency [GO:0003356]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BI79}. Cell projection, cilium {ECO:0000269|PubMed:27120127}. Note=Localizes to cytoplasm and motile cilium. {ECO:0000250|UniProtKB:Q8BI79}.
Q4G163	reviewed	FBX43_HUMAN	F-box only protein 43 (Endogenous meiotic inhibitor 2)	FBXO43 EMI2	Homo sapiens (Human)	708	FUNCTION: Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:34052850, PubMed:34595750). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. {ECO:0000250|UniProtKB:Q8CDI2, ECO:0000269|PubMed:34052850, ECO:0000269|PubMed:34595750}.		meiotic cell cycle [GO:0051321]; negative regulation of cell cycle process [GO:0010948]; negative regulation of meiotic nuclear division [GO:0045835]; protein ubiquitination [GO:0016567]; regulation of mitotic nuclear division [GO:0007088]	nucleus [GO:0005634]	zinc ion binding [GO:0008270]	nucleus [GO:0005634]; zinc ion binding [GO:0008270]; meiotic cell cycle [GO:0051321]; negative regulation of cell cycle process [GO:0010948]; negative regulation of meiotic nuclear division [GO:0045835]; protein ubiquitination [GO:0016567]; regulation of mitotic nuclear division [GO:0007088]	
Q4G176	reviewed	ACSF3_HUMAN	Malonate--CoA ligase ACSF3, mitochondrial (EC 6.2.1.76) (Acyl-CoA synthetase family member 3)	ACSF3 PSEC0197	Homo sapiens (Human)	576	FUNCTION: Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester (PubMed:21846720, PubMed:21841779). May have some preference toward very-long-chain substrates (PubMed:17762044). {ECO:0000269|PubMed:17762044, ECO:0000269|PubMed:21841779, ECO:0000269|PubMed:21846720}.		fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; malonate catabolic process [GO:0090410]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	acid-thiol ligase activity [GO:0016878]; ATP binding [GO:0005524]; malonyl-CoA synthetase activity [GO:0090409]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; acid-thiol ligase activity [GO:0016878]; ATP binding [GO:0005524]; malonyl-CoA synthetase activity [GO:0090409]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; malonate catabolic process [GO:0090410]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21841779, ECO:0000269|PubMed:21846720}.
Q4J6C6	reviewed	PPCEL_HUMAN	Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like)	PREPL KIAA0436	Homo sapiens (Human)	727	FUNCTION: Serine peptidase whose precise substrate specificity remains unclear (PubMed:16143824, PubMed:16385448, PubMed:28726805). Does not cleave peptides after a arginine or lysine residue (PubMed:16143824). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:23321636). May play a role in the regulation of synaptic vesicle exocytosis (PubMed:24610330). {ECO:0000269|PubMed:16143824, ECO:0000269|PubMed:16385448, ECO:0000269|PubMed:23321636, ECO:0000269|PubMed:24610330, ECO:0000269|PubMed:28726805}.		Golgi to plasma membrane protein transport [GO:0043001]; proteolysis [GO:0006508]; regulation of synaptic vesicle exocytosis [GO:2000300]; retrograde transport, endosome to Golgi [GO:0042147]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; Golgi to plasma membrane protein transport [GO:0043001]; proteolysis [GO:0006508]; regulation of synaptic vesicle exocytosis [GO:2000300]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16385448, ECO:0000269|PubMed:23485813}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8C167}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8C167}. Golgi apparatus {ECO:0000250|UniProtKB:Q8C167}. Nucleus {ECO:0000269|PubMed:23485813}. Note=Co-localizes with AP-1 in the trans-Golgi network (By similarity). Co-localizes with MAP2 and ACTB on the cytoskeleton (By similarity). Co-localizes with STX6 and GOSR2 at the Golgi apparatus (By similarity). {ECO:0000250|UniProtKB:Q8C167}.
Q4JDL3	reviewed	PTN20_HUMAN	Tyrosine-protein phosphatase non-receptor type 20 (hPTPN20) (EC 3.1.3.48)	PTPN20 PTPN20A PTPN20B	Homo sapiens (Human)	420	FUNCTION: Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.	MISCELLANEOUS: [Isoform 9]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	dephosphorylation [GO:0016311]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]	phosphoprotein phosphatase activity [GO:0004721]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; phosphoprotein phosphatase activity [GO:0004721]; dephosphorylation [GO:0016311]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15790311}. Cytoplasm {ECO:0000269|PubMed:15790311}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15790311}. Note=Colocalizes with the microtubule-organizing center and intracellular membrane compartments.
Q4KMG0	reviewed	CDON_HUMAN	Cell adhesion molecule-related/down-regulated by oncogenes	CDON CDO	Homo sapiens (Human)	1287	FUNCTION: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). {ECO:0000250}.		anterior/posterior pattern specification [GO:0009952]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; cell-cell adhesion [GO:0098609]; cerebral cortex development [GO:0021987]; embryonic body morphogenesis [GO:0010172]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; lens development in camera-type eye [GO:0002088]; myoblast fusion [GO:0007520]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; neuron differentiation [GO:0030182]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal muscle satellite cell differentiation [GO:0014816]; smoothened signaling pathway [GO:0007224]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; anterior/posterior pattern specification [GO:0009952]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; cell-cell adhesion [GO:0098609]; cerebral cortex development [GO:0021987]; embryonic body morphogenesis [GO:0010172]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; lens development in camera-type eye [GO:0002088]; myoblast fusion [GO:0007520]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; neuron differentiation [GO:0030182]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal muscle satellite cell differentiation [GO:0014816]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q4KMG9	reviewed	TM52B_HUMAN	Transmembrane protein 52B	TMEM52B C12orf59 UNQ5927/PRO19821	Homo sapiens (Human)	183				extracellular exosome [GO:0070062]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q4KMP7	reviewed	TB10B_HUMAN	TBC1 domain family member 10B (Rab27A-GAP-beta)	TBC1D10B FP2461	Homo sapiens (Human)	808	FUNCTION: Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}.		regulation of GTPase activity [GO:0043087]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; regulation of GTPase activity [GO:0043087]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16923811}. Note=In melanocytes, located at the periphery of cells.
Q4KMQ1	reviewed	TPRN_HUMAN	Taperin	TPRN C9orf75	Homo sapiens (Human)	711			auditory receptor cell stereocilium organization [GO:0060088]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045]	stereocilium [GO:0032420]; stereocilium base [GO:0120044]	phosphatase binding [GO:0019902]	stereocilium [GO:0032420]; stereocilium base [GO:0120044]; phosphatase binding [GO:0019902]; auditory receptor cell stereocilium organization [GO:0060088]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045]	SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000250}. Note=Localized prominently at the taper regions of hair cell stereocilia. {ECO:0000250}.
Q4KMQ2	reviewed	ANO6_HUMAN	Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)	ANO6 TMEM16F	Homo sapiens (Human)	910	FUNCTION: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. {ECO:0000250|UniProtKB:Q6P9J9, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21107324, ECO:0000269|PubMed:21908539, ECO:0000269|PubMed:22006324, ECO:0000269|PubMed:22946059}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia. {ECO:0000269|PubMed:33827113}.	MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and are predicted to have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. {ECO:0000305}.	activation of blood coagulation via clotting cascade [GO:0002543]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; calcium ion transmembrane transport [GO:0070588]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cell volume [GO:0045794]; phosphatidylserine exposure on blood platelet [GO:0097045]; plasma membrane phospholipid scrambling [GO:0017121]; pore complex assembly [GO:0046931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of potassium ion export across plasma membrane [GO:1903766]; purinergic nucleotide receptor signaling pathway [GO:0035590]; sodium ion transmembrane transport [GO:0035725]	cell surface [GO:0009986]; chloride channel complex [GO:0034707]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	calcium activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983]; voltage-gated chloride channel activity [GO:0005247]; voltage-gated monoatomic ion channel activity [GO:0005244]	cell surface [GO:0009986]; chloride channel complex [GO:0034707]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; calcium activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983]; voltage-gated chloride channel activity [GO:0005247]; voltage-gated monoatomic ion channel activity [GO:0005244]; activation of blood coagulation via clotting cascade [GO:0002543]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; calcium ion transmembrane transport [GO:0070588]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cell volume [GO:0045794]; phosphatidylserine exposure on blood platelet [GO:0097045]; plasma membrane phospholipid scrambling [GO:0017121]; pore complex assembly [GO:0046931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of potassium ion export across plasma membrane [GO:1903766]; purinergic nucleotide receptor signaling pathway [GO:0035590]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21107324, ECO:0000269|PubMed:22075693, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21107324, ECO:0000269|PubMed:22075693, ECO:0000269|PubMed:22946059}. Note=Shows an intracellular localization according to PubMed:22075693.
Q4KWH8	reviewed	PLCH1_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3)	PLCH1 KIAA1069 PLCL3	Homo sapiens (Human)	1693	FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}.		lipid catabolic process [GO:0016042]; phosphatidylinositol-mediated signaling [GO:0048015]; release of sequestered calcium ion into cytosol [GO:0051209]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase C activity [GO:0050429]; phosphatidylinositol phospholipase C activity [GO:0004435]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase C activity [GO:0050429]; phosphatidylinositol phospholipase C activity [GO:0004435]; lipid catabolic process [GO:0016042]; phosphatidylinositol-mediated signaling [GO:0048015]; release of sequestered calcium ion into cytosol [GO:0051209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15702972, ECO:0000269|PubMed:33820834}. Membrane {ECO:0000269|PubMed:15702972}.
Q4L180	reviewed	FIL1L_HUMAN	Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1)	FILIP1L COL4A3BPIP DOC1 GIP90	Homo sapiens (Human)	1135	FUNCTION: Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}.			cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18794120}. Membrane {ECO:0000269|PubMed:18794120}. Nucleus {ECO:0000269|PubMed:18794120}.
Q4L235	reviewed	ACSF4_HUMAN	Beta-alanine-activating enzyme (EC 6.2.1.-) (Acyl-CoA synthetase family member 4) (Protein NRPS998)	AASDH ACSF4 U26 HSPC318	Homo sapiens (Human)	1098	FUNCTION: Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA. {ECO:0000250|UniProtKB:Q80WC9}.		amino acid activation for nonribosomal peptide biosynthetic process [GO:0043041]; beta-alanine metabolic process [GO:0019482]; fatty acid metabolic process [GO:0006631]		acid-thiol ligase activity [GO:0016878]; ATP binding [GO:0005524]	acid-thiol ligase activity [GO:0016878]; ATP binding [GO:0005524]; amino acid activation for nonribosomal peptide biosynthetic process [GO:0043041]; beta-alanine metabolic process [GO:0019482]; fatty acid metabolic process [GO:0006631]	
Q4LDE5	reviewed	SVEP1_HUMAN	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)	SVEP1 C9orf13 CCP22 SELOB	Homo sapiens (Human)	3571	FUNCTION: May play a role in the cell attachment process. {ECO:0000250}.		cell adhesion [GO:0007155]; epidermis development [GO:0008544]; gene expression [GO:0010467]; lymph circulation [GO:0003017]; lymph vessel morphogenesis [GO:0036303]; negative regulation of complement activation, classical pathway [GO:0045959]; Tie signaling pathway [GO:0048014]; tight junction organization [GO:0120193]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; chromatin binding [GO:0003682]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; chromatin binding [GO:0003682]; cell adhesion [GO:0007155]; epidermis development [GO:0008544]; gene expression [GO:0010467]; lymph circulation [GO:0003017]; lymph vessel morphogenesis [GO:0036303]; negative regulation of complement activation, classical pathway [GO:0045959]; Tie signaling pathway [GO:0048014]; tight junction organization [GO:0120193]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16206243}. Membrane {ECO:0000269|PubMed:16206243}; Peripheral membrane protein {ECO:0000269|PubMed:16206243}.
Q4LDG9	reviewed	DNAL1_HUMAN	Dynein axonemal light chain 1 (LC1)	DNAL1 C14orf168	Homo sapiens (Human)	190	FUNCTION: Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (PubMed:21496787). {ECO:0000250|UniProtKB:Q9XHH2, ECO:0000303|PubMed:21496787}.	MISCELLANEOUS: Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms. {ECO:0000250|UniProtKB:Q9XHH2}.	outer dynein arm assembly [GO:0036158]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]	alpha-tubulin binding [GO:0043014]; dynein heavy chain binding [GO:0045504]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; alpha-tubulin binding [GO:0043014]; dynein heavy chain binding [GO:0045504]; outer dynein arm assembly [GO:0036158]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}.
Q4LDR2	reviewed	CTXN3_HUMAN	Cortexin-3 (Kidney and brain-expressed protein)	CTXN3 KABE	Homo sapiens (Human)	81				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q4LE39	reviewed	ARI4B_HUMAN	AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1)	ARID4B BRCAA1 RBBP1L1 RBP1L1 SAP180	Homo sapiens (Human)	1312	FUNCTION: Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}.		DNA methylation [GO:0006306]; establishment of Sertoli cell barrier [GO:0097368]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]	transcription cis-regulatory region binding [GO:0000976]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; transcription cis-regulatory region binding [GO:0000976]; DNA methylation [GO:0006306]; establishment of Sertoli cell barrier [GO:0097368]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}. Cytoplasm {ECO:0000269|PubMed:11481388, ECO:0000269|PubMed:15247124}. Note=Cytoplasmic in breast cancer cells. {ECO:0000269|PubMed:15247124}.
Q4U2R8	reviewed	S22A6_HUMAN	Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1)	SLC22A6 OAT1 PAHT	Homo sapiens (Human)	563	FUNCTION: Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate (PubMed:9950961, PubMed:11907186, PubMed:11669456, PubMed:14675047, PubMed:22108572, PubMed:23832370, PubMed:28534121). Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine (PubMed:9887087). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (PubMed:28534121). Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion (PubMed:11907186). Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP (PubMed:26377792). Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain (PubMed:22108572, PubMed:23832370). May transport glutamate (PubMed:26377792). Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body (PubMed:11669456, PubMed:14675047). Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate (PubMed:14675047, PubMed:26377792). Xenobiotics include the mycotoxin ochratoxin (OTA) (PubMed:11669456). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier (PubMed:35307651). {ECO:0000269|PubMed:11669456, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:14675047, ECO:0000269|PubMed:22108572, ECO:0000269|PubMed:23832370, ECO:0000269|PubMed:26377792, ECO:0000269|PubMed:28534121, ECO:0000269|PubMed:35307651, ECO:0000269|PubMed:9887087, ECO:0000269|PubMed:9950961}.	MISCELLANEOUS: Involved in the renal transport of a variety of drugs with well-known nephrotoxic potential, therefore may play a role in the etiology of the drug-associated nephrotoxicity (PubMed:10462545, PubMed:12538807). Uptakes the diagnostic agent PAH/para-aminohippurate and clinically used drugs (PubMed:9762842, PubMed:9887087, PubMed:10462545, PubMed:12538807, PubMed:15644426, PubMed:17038320, PubMed:17502342, PubMed:23832370, PubMed:26377792, PubMed:15914676). Mediates the pH- and chloride-dependent bidirectional transport of PAH/para-aminohippurate in exchange for 2-oxoglutarate or glutarate as counteranions (PubMed:9950961, PubMed:15644426, PubMed:26377792). Can also mediate PAH/cGMP exchange (PubMed:26377792). {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15644426, ECO:0000269|PubMed:15914676, ECO:0000269|PubMed:17038320, ECO:0000269|PubMed:17502342, ECO:0000269|PubMed:23832370, ECO:0000269|PubMed:26377792, ECO:0000269|PubMed:9762842, ECO:0000269|PubMed:9887087, ECO:0000269|PubMed:9950961}.	alpha-ketoglutarate transport [GO:0015742]; metanephric proximal tubule development [GO:0072237]; monoatomic anion transport [GO:0006820]; organic anion transport [GO:0015711]; prostaglandin transport [GO:0015732]; renal tubular secretion [GO:0097254]; response to organic cyclic compound [GO:0014070]; sodium-independent organic anion transport [GO:0043252]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; antiporter activity [GO:0015297]; chloride ion binding [GO:0031404]; identical protein binding [GO:0042802]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; antiporter activity [GO:0015297]; chloride ion binding [GO:0031404]; identical protein binding [GO:0042802]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]; alpha-ketoglutarate transport [GO:0015742]; metanephric proximal tubule development [GO:0072237]; monoatomic anion transport [GO:0006820]; organic anion transport [GO:0015711]; prostaglandin transport [GO:0015732]; renal tubular secretion [GO:0097254]; response to organic cyclic compound [GO:0014070]; sodium-independent organic anion transport [GO:0043252]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:9887087}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basolateral membrane of renal proximal tubular cells (PubMed:9887087). Localized to the basal membrane of Sertoli cells (PubMed:35307651). {ECO:0000269|PubMed:35307651, ECO:0000269|PubMed:9887087}.
Q4V328	reviewed	GRAP1_HUMAN	GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)]	GRIPAP1 KIAA1167	Homo sapiens (Human)	841	FUNCTION: Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}.	MISCELLANEOUS: Antibodies against GRIPAP1 have been found in sera of a patient who developed Raynaud's syndrome and telangiectasias.	negative regulation of receptor clustering [GO:1903910]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; regulation of modification of synaptic structure [GO:1905244]; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0099152]; regulation of recycling endosome localization within postsynapse [GO:0099158]	axon [GO:0030424]; blood microparticle [GO:0072562]; cytosol [GO:0005829]; dendrite [GO:0030425]; extrinsic component of postsynaptic early endosome membrane [GO:0098998]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; postsynaptic recycling endosome [GO:0098837]; presynaptic membrane [GO:0042734]; recycling endosome membrane [GO:0055038]	guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]	axon [GO:0030424]; blood microparticle [GO:0072562]; cytosol [GO:0005829]; dendrite [GO:0030425]; extrinsic component of postsynaptic early endosome membrane [GO:0098998]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; postsynaptic recycling endosome [GO:0098837]; presynaptic membrane [GO:0042734]; recycling endosome membrane [GO:0055038]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; negative regulation of receptor clustering [GO:1903910]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; regulation of modification of synaptic structure [GO:1905244]; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0099152]; regulation of recycling endosome localization within postsynapse [GO:0099158]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:15897011}; Peripheral membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9JHZ4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JHZ4}. Cell projection, axon {ECO:0000250|UniProtKB:Q9JHZ4}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JHZ4}. Synapse {ECO:0000250|UniProtKB:Q9JHZ4}. Note=Localizes to recycling endosomal tubules that are emanating from early endosomes. {ECO:0000250|UniProtKB:Q9JHZ4}.
Q4V9L6	reviewed	TM119_HUMAN	Transmembrane protein 119 (Osteoblast induction factor) (OBIF)	TMEM119 PSEC0199 UNQ731/PRO1415	Homo sapiens (Human)	283	FUNCTION: Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R138, ECO:0000269|PubMed:20025746}.		biomineral tissue development [GO:0031214]; endochondral ossification [GO:0001958]; negative regulation of bone resorption [GO:0045779]; negative regulation of myotube differentiation [GO:0010832]; osteoblast differentiation [GO:0001649]; positive regulation of bone development [GO:1903012]; positive regulation of bone mineralization [GO:0030501]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein phosphorylation [GO:0001934]; spermatid differentiation [GO:0048515]; spermatogenesis [GO:0007283]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]		endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; biomineral tissue development [GO:0031214]; endochondral ossification [GO:0001958]; negative regulation of bone resorption [GO:0045779]; negative regulation of myotube differentiation [GO:0010832]; osteoblast differentiation [GO:0001649]; positive regulation of bone development [GO:1903012]; positive regulation of bone mineralization [GO:0030501]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein phosphorylation [GO:0001934]; spermatid differentiation [GO:0048515]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20025746, ECO:0000269|PubMed:26250788}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8R138}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R138}.
Q4VC12	reviewed	MSS51_HUMAN	Putative protein MSS51 homolog, mitochondrial (Zinc finger MYND domain-containing protein 17)	MSS51 ZMYND17	Homo sapiens (Human)	460					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q4VC44	reviewed	FWCH1_HUMAN	FLYWCH-type zinc finger-containing protein 1	FLYWCH1 KIAA1552	Homo sapiens (Human)	716	FUNCTION: Transcription cofactor (PubMed:30097457). Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding (PubMed:30097457). May play a role in DNA-damage response signaling (PubMed:33924684). Binds specifically to DNA sequences at peri-centromeric chromatin loci. {ECO:0000269|PubMed:30097457, ECO:0000269|PubMed:33924684, ECO:0000269|PubMed:34408139}.		DNA damage response [GO:0006974]; negative regulation of transcription by RNA polymerase II [GO:0000122]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; pericentric heterochromatin [GO:0005721]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coactivator binding [GO:0001223]; transcription corepressor activity [GO:0003714]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; pericentric heterochromatin [GO:0005721]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coactivator binding [GO:0001223]; transcription corepressor activity [GO:0003714]; DNA damage response [GO:0006974]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33924684}. Chromosome, centromere {ECO:0000269|PubMed:34408139}. Note=Localized to peri-centromeric, H3K9me3-marked heterochromatin. {ECO:0000269|PubMed:34408139}.
Q4VCS5	reviewed	AMOT_HUMAN	Angiomotin	AMOT KIAA1071	Homo sapiens (Human)	1084	FUNCTION: Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097}.	MISCELLANEOUS: 'Motus' means 'motility' in Latin.	actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cell migration involved in gastrulation [GO:0042074]; cell-cell junction assembly [GO:0007043]; chemotaxis [GO:0006935]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; establishment of epithelial cell polarity [GO:0090162]; gastrulation with mouth forming second [GO:0001702]; hippo signaling [GO:0035329]; in utero embryonic development [GO:0001701]; negative regulation of angiogenesis [GO:0016525]; negative regulation of vascular permeability [GO:0043116]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell size [GO:0045793]; positive regulation of embryonic development [GO:0040019]; positive regulation of stress fiber assembly [GO:0051496]; protein localization [GO:0008104]; regulation of cell migration [GO:0030334]; regulation of small GTPase mediated signal transduction [GO:0051056]; vasculogenesis [GO:0001570]	actin filament [GO:0005884]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; external side of plasma membrane [GO:0009897]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; stress fiber [GO:0001725]	angiostatin binding [GO:0043532]; signaling receptor activity [GO:0038023]	actin filament [GO:0005884]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; external side of plasma membrane [GO:0009897]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; stress fiber [GO:0001725]; angiostatin binding [GO:0043532]; signaling receptor activity [GO:0038023]; actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cell migration involved in gastrulation [GO:0042074]; cell-cell junction assembly [GO:0007043]; chemotaxis [GO:0006935]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; establishment of epithelial cell polarity [GO:0090162]; gastrulation with mouth forming second [GO:0001702]; hippo signaling [GO:0035329]; in utero embryonic development [GO:0001701]; negative regulation of angiogenesis [GO:0016525]; negative regulation of vascular permeability [GO:0043116]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell size [GO:0045793]; positive regulation of embryonic development [GO:0040019]; positive regulation of stress fiber assembly [GO:0051496]; protein localization [GO:0008104]; regulation of cell migration [GO:0030334]; regulation of small GTPase mediated signal transduction [GO:0051056]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:16043488}. Note=Localized on the cell surface. May act as a transmembrane protein.
Q4VNC1	reviewed	AT134_HUMAN	Probable cation-transporting ATPase 13A4 (EC 7.2.2.-) (P5-ATPase isoform 4)	ATP13A4 UNQ3052/PRO9871	Homo sapiens (Human)	1196		MISCELLANEOUS: [Isoform 2]: Dubious isoform lacking mature mRNA evidence. {ECO:0000305}.	intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; polyamine transmembrane transport [GO:1902047]	early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; polyamine transmembrane transporter activity [GO:0015203]	early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; polyamine transmembrane transporter activity [GO:0015203]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; polyamine transmembrane transport [GO:1902047]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:Q5XF90}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q5XF90}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q5XF90}; Multi-pass membrane protein {ECO:0000255}.
Q4ZG55	reviewed	GREB1_HUMAN	Protein GREB1 (Gene regulated in breast cancer 1 protein)	GREB1 KIAA0575	Homo sapiens (Human)	1949	FUNCTION: May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.			extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]		extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q4ZHG4	reviewed	FNDC1_HUMAN	Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein)	FNDC1 FNDC2 KIAA1866 MEL4B3	Homo sapiens (Human)	1894	FUNCTION: May be an activator of G protein signaling. {ECO:0000250}.			extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q4ZJI4	reviewed	SL9B1_HUMAN	Sodium/hydrogen exchanger 9B1 (Na(+)/H(+) exchanger-like domain-containing protein 1) (NHE domain-containing protein 1) (Sodium/hydrogen exchanger-like domain-containing protein 1) (Solute carrier family 9, subfamily B member 1)	SLC9B1 NHA1 NHEDC1	Homo sapiens (Human)	515	FUNCTION: Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility. {ECO:0000250|UniProtKB:Q8C0X2}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	flagellated sperm motility [GO:0030317]; monoatomic ion transmembrane transport [GO:0034220]; regulation of intracellular pH [GO:0051453]; single fertilization [GO:0007338]	plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]	sodium:proton antiporter activity [GO:0015385]	plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]; sodium:proton antiporter activity [GO:0015385]; flagellated sperm motility [GO:0030317]; monoatomic ion transmembrane transport [GO:0034220]; regulation of intracellular pH [GO:0051453]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q8C0X2}; Multi-pass membrane protein {ECO:0000255}.
Q502W6	reviewed	VWA3B_HUMAN	von Willebrand factor A domain-containing protein 3B (VWA domain-containing protein 3B)	VWA3B	Homo sapiens (Human)	1294				cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26157035}.
Q504Q3	reviewed	PAN2_HUMAN	PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2)	PAN2 KIAA0710 USP52	Homo sapiens (Human)	1202	FUNCTION: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618, ECO:0000269|PubMed:23398456}.		mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]	cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; PAN complex [GO:0031251]	3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; poly(A)-specific ribonuclease activity [GO:0004535]	cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; PAN complex [GO:0031251]; 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; poly(A)-specific ribonuclease activity [GO:0004535]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618}. Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:18625844, ECO:0000269|PubMed:23398456}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:16284618}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:16284618}.
Q504Y0	reviewed	S39AC_HUMAN	Zinc transporter ZIP12 (LIV-1 subfamily of ZIP zinc transporter 8) (LZT-Hs8) (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12)	SLC39A12 ZIP12	Homo sapiens (Human)	691	FUNCTION: Uniporter that promotes Zn(2+) import from the extracellular space to the cytoplasm across the cell membrane. The transport activity is temperature dependent. May play a role in neurulation and neurite extension. May play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis. {ECO:0000250|UniProtKB:Q5FWH7}.		neural tube formation [GO:0001841]; neuron projection extension [GO:1990138]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of microtubule polymerization [GO:0031113]; regulation of neuron projection development [GO:0010975]; response to decreased oxygen levels [GO:0036293]; signal transduction [GO:0007165]; zinc ion import across plasma membrane [GO:0071578]	extracellular vesicle [GO:1903561]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]	extracellular vesicle [GO:1903561]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]; neural tube formation [GO:0001841]; neuron projection extension [GO:1990138]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of microtubule polymerization [GO:0031113]; regulation of neuron projection development [GO:0010975]; response to decreased oxygen levels [GO:0036293]; signal transduction [GO:0007165]; zinc ion import across plasma membrane [GO:0071578]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q5FWH7}; Multi-pass membrane protein {ECO:0000255}. Note=At low Zn(2+) extracellular concentration, is redistributed from the perinuclear space to the cytoplasm and plasma membrane. {ECO:0000250|UniProtKB:Q5FWH7}.
Q504Y2	reviewed	PKDCC_HUMAN	Extracellular tyrosine-protein kinase PKDCC (EC 2.7.10.2) (Protein kinase domain-containing protein, cytoplasmic) (Protein kinase-like protein SgK493) (Sugen kinase 493) (Vertebrate lonesome kinase)	PKDCC SGK493 VLK	Homo sapiens (Human)	493	FUNCTION: Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q5RJI4, ECO:0000269|PubMed:25171405}.		bone mineralization [GO:0030282]; cell differentiation [GO:0030154]; embryonic digestive tract development [GO:0048566]; limb morphogenesis [GO:0035108]; lung alveolus development [GO:0048286]; multicellular organism growth [GO:0035264]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of chondrocyte differentiation [GO:0032332]; protein transport [GO:0015031]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; bone mineralization [GO:0030282]; cell differentiation [GO:0030154]; embryonic digestive tract development [GO:0048566]; limb morphogenesis [GO:0035108]; lung alveolus development [GO:0048286]; multicellular organism growth [GO:0035264]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of chondrocyte differentiation [GO:0032332]; protein transport [GO:0015031]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25171405}. Golgi apparatus {ECO:0000250|UniProtKB:Q5RJI4}.
Q504Y3	reviewed	ZCPW2_HUMAN	Zinc finger CW-type PWWP domain protein 2	ZCWPW2	Homo sapiens (Human)	356	FUNCTION: Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:26933034}.			nucleus [GO:0005634]	methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]	
Q52LG2	reviewed	KR132_HUMAN	Keratin-associated protein 13-2	KRTAP13-2 KAP13.2	Homo sapiens (Human)	175	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q52LJ0	reviewed	FA98B_HUMAN	Protein FAM98B	FAM98B	Homo sapiens (Human)	433	FUNCTION: Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). {ECO:0000269|PubMed:28040436}.	MISCELLANEOUS: [Isoform 1]: Dubious isoform due to intron retention. {ECO:0000305}.	positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; protein methylation [GO:0006479]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669]	identical protein binding [GO:0042802]; protein methyltransferase activity [GO:0008276]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669]; identical protein binding [GO:0042802]; protein methyltransferase activity [GO:0008276]; RNA binding [GO:0003723]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; protein methylation [GO:0006479]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24608264}. Cytoplasm {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:24608264}.
Q52LW3	reviewed	RHG29_HUMAN	Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29)	ARHGAP29 PARG1	Homo sapiens (Human)	1261	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}.		regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	
Q53EL6	reviewed	PDCD4_HUMAN	Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a)	PDCD4 H731	Homo sapiens (Human)	469	FUNCTION: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.		apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; cellular response to lipopolysaccharide [GO:0071222]; epithelial to mesenchymal transition involved in cardiac fibroblast development [GO:0060940]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of inflammatory response [GO:0050729]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; response to alkaloid [GO:0043279]; response to hormone [GO:0009725]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; cellular response to lipopolysaccharide [GO:0071222]; epithelial to mesenchymal transition involved in cardiac fibroblast development [GO:0060940]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of inflammatory response [GO:0050729]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; response to alkaloid [GO:0043279]; response to hormone [GO:0009725]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61823}. Cytoplasm {ECO:0000250|UniProtKB:Q61823}. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). {ECO:0000269|PubMed:16357133}.
Q53EL9	reviewed	SEZ6_HUMAN	Seizure protein 6 homolog (SEZ-6) (hSEZ-6)	SEZ6	Homo sapiens (Human)	994	FUNCTION: May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity). {ECO:0000250}.		adult locomotory behavior [GO:0008344]; cerebellar Purkinje cell layer development [GO:0021680]; excitatory postsynaptic potential [GO:0060079]; regulation of dendrite development [GO:0050773]; regulation of protein kinase C signaling [GO:0090036]; synapse maturation [GO:0060074]	apical dendrite [GO:0097440]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]		apical dendrite [GO:0097440]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; adult locomotory behavior [GO:0008344]; cerebellar Purkinje cell layer development [GO:0021680]; excitatory postsynaptic potential [GO:0060079]; regulation of dendrite development [GO:0050773]; regulation of protein kinase C signaling [GO:0090036]; synapse maturation [GO:0060074]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized on dendrites and in the synaptic and postsynaptic fraction. {ECO:0000250}.
Q53EP0	reviewed	FND3B_HUMAN	Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37)	FNDC3B FAD104 NS5ABP37 UNQ2421/PRO4979/PRO34274	Homo sapiens (Human)	1204	FUNCTION: May be a positive regulator of adipogenesis. {ECO:0000269|PubMed:15564382}.			membrane [GO:0016020]	RNA binding [GO:0003723]	membrane [GO:0016020]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q53ET0	reviewed	CRTC2_HUMAN	CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2)	CRTC2 TORC2	Homo sapiens (Human)	693	FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}.		gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homotetramerization [GO:0051289]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cAMP response element binding protein binding [GO:0008140]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cAMP response element binding protein binding [GO:0008140]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homotetramerization [GO:0051289]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15589160}. Nucleus {ECO:0000269|PubMed:15589160}. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein (PubMed:15454081). In response to cAMP levels and glucagon, relocated to the nucleus (PubMed:15454081). {ECO:0000269|PubMed:15454081}.
Q53EU6	reviewed	GPAT3_HUMAN	Glycerol-3-phosphate acyltransferase 3 (GPAT-3) (EC 2.3.1.15) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10) (AGPAT 10) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9) (1-AGP acyltransferase 9) (1-AGPAT 9) (EC 2.3.1.51) (Acyl-CoA:glycerol-3-phosphate acyltransferase 3) (hGPAT3) (Lung cancer metastasis-associated protein 1) (Lysophosphatidic acid acyltransferase theta) (LPAAT-theta) (MAG-1)	GPAT3 AGPAT9 MAG1 HMFN0839 UNQ2753/PRO6492	Homo sapiens (Human)	434	FUNCTION: Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427). Protects cells against lipotoxicity (PubMed:30846318). {ECO:0000269|PubMed:17170135, ECO:0000269|PubMed:19318427, ECO:0000269|PubMed:30846318}.		CDP-diacylglycerol biosynthetic process [GO:0016024]; glycerol-3-phosphate metabolic process [GO:0006072]; phosphatidic acid biosynthetic process [GO:0006654]; regulation of TOR signaling [GO:0032006]; triglyceride biosynthetic process [GO:0019432]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420]; CDP-diacylglycerol biosynthetic process [GO:0016024]; glycerol-3-phosphate metabolic process [GO:0006072]; phosphatidic acid biosynthetic process [GO:0006654]; regulation of TOR signaling [GO:0032006]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17002884, ECO:0000269|PubMed:19318427}; Multi-pass membrane protein {ECO:0000255}.
Q53EZ4	reviewed	CEP55_HUMAN	Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6)	CEP55 C10orf3 URCC6	Homo sapiens (Human)	464	FUNCTION: Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:28264986}.		cranial skeletal system development [GO:1904888]; establishment of protein localization [GO:0045184]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]	centriole [GO:0005814]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; midbody [GO:0030496]	identical protein binding [GO:0042802]	centriole [GO:0005814]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; midbody [GO:0030496]; identical protein binding [GO:0042802]; cranial skeletal system development [GO:1904888]; establishment of protein localization [GO:0045184]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28264986}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:16198290}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16198290}. Cleavage furrow {ECO:0000269|PubMed:16198290}. Midbody, Midbody ring {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:28264986}. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loses affinity for the centrosome at the onset of prophase and diffuses throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis. {ECO:0000269|PubMed:16198290}.
Q53F19	reviewed	NCBP3_HUMAN	Nuclear cap-binding protein subunit 3 (Protein ELG)	NCBP3 C17orf85	Homo sapiens (Human)	620	FUNCTION: Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}.		7-methylguanosine mRNA capping [GO:0006370]; defense response to virus [GO:0051607]; mRNA export from nucleus [GO:0006406]; mRNA transcription by RNA polymerase II [GO:0042789]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; snRNA export from nucleus [GO:0006408]	cytoplasm [GO:0005737]; mRNA cap binding complex [GO:0005845]; nuclear cap binding complex [GO:0005846]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA cap binding complex [GO:0034518]	mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]	cytoplasm [GO:0005737]; mRNA cap binding complex [GO:0005845]; nuclear cap binding complex [GO:0005846]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA cap binding complex [GO:0034518]; mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; 7-methylguanosine mRNA capping [GO:0006370]; defense response to virus [GO:0051607]; mRNA export from nucleus [GO:0006406]; mRNA transcription by RNA polymerase II [GO:0042789]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; snRNA export from nucleus [GO:0006408]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26382858}. Cytoplasm {ECO:0000269|PubMed:26382858}.
Q53F39	reviewed	MPPE1_HUMAN	Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5)	MPPE1 PGAP5 PP579	Homo sapiens (Human)	396	FUNCTION: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins. {ECO:0000269|PubMed:19837036, ECO:0000269|PubMed:29374258}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; GPI anchor biosynthetic process [GO:0006506]	cis-Golgi network [GO:0005801]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	GPI anchor binding [GO:0034235]; GPI-mannose ethanolamine phosphate phosphodiesterase activity [GO:0062050]; manganese ion binding [GO:0030145]	cis-Golgi network [GO:0005801]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; GPI anchor binding [GO:0034235]; GPI-mannose ethanolamine phosphate phosphodiesterase activity [GO:0062050]; manganese ion binding [GO:0030145]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; GPI anchor biosynthetic process [GO:0006506]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:19837036}; Multi-pass membrane protein {ECO:0000269|PubMed:19837036}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:19837036}; Multi-pass membrane protein {ECO:0000269|PubMed:19837036}. Note=Also localizes to endoplasmic reticulum exit site.
Q53FA7	reviewed	QORX_HUMAN	Quinone oxidoreductase PIG3 (EC 1.6.5.5) (NADPH:quinone reductase PIG3) (Tumor protein p53-inducible protein 3) (Protein PIG3) (p53-induced gene 3 protein)	TP53I3 PIG3	Homo sapiens (Human)	332	FUNCTION: Catalyzes the NADPH-dependent reduction of quinones (PubMed:19349281). Exhibits a low enzymatic activity with beta-naphthoquinones, with a strong preference for the ortho-quinone isomer (1,2-beta-naphthoquinone) over the para isomer (1,4-beta-naphthoquinone). Also displays a low reductase activity for non-quinone compounds such as diamine and 2,6-dichloroindophenol (in vitro) (PubMed:19349281). Involved in the generation of reactive oxygen species (ROS) (PubMed:19349281). {ECO:0000269|PubMed:19349281}.	MISCELLANEOUS: [Isoform 1]: Major isoform under normal light conditions.; MISCELLANEOUS: [Isoform 2]: Major isoform under UV light exposure. Undergoes rapid proteolytic degradation by the proteasome. {ECO:0000305}.	NADP metabolic process [GO:0006739]	cytosol [GO:0005829]	NADPH binding [GO:0070402]; NADPH:quinone reductase activity [GO:0003960]; protein homodimerization activity [GO:0042803]; quinone binding [GO:0048038]	cytosol [GO:0005829]; NADPH binding [GO:0070402]; NADPH:quinone reductase activity [GO:0003960]; protein homodimerization activity [GO:0042803]; quinone binding [GO:0048038]; NADP metabolic process [GO:0006739]	
Q53FD0	reviewed	ZC21C_HUMAN	Zinc finger C2HC domain-containing protein 1C	ZC2HC1C C14orf140 FAM164C	Homo sapiens (Human)	456					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q53FP2	reviewed	NACHO_HUMAN	Novel acetylcholine receptor chaperone	TMEM35A NACHO TMEM35	Homo sapiens (Human)	167	FUNCTION: Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:28445721). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (PubMed:32676916). {ECO:0000250|UniProtKB:Q9D328, ECO:0000269|PubMed:26875622, ECO:0000269|PubMed:27789755, ECO:0000269|PubMed:28445721, ECO:0000269|PubMed:32204458, ECO:0000269|PubMed:32676916, ECO:0000269|PubMed:32783947}.		chaperone-mediated protein complex assembly [GO:0051131]; positive regulation of protein localization to cell surface [GO:2000010]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; peroxisomal membrane [GO:0005778]	acetylcholine receptor regulator activity [GO:0030548]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; peroxisomal membrane [GO:0005778]; acetylcholine receptor regulator activity [GO:0030548]; chaperone-mediated protein complex assembly [GO:0051131]; positive regulation of protein localization to cell surface [GO:2000010]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:Q9D328}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q6JAM9}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D328}; Multi-pass membrane protein {ECO:0000255}. Note=Shedding may lead to a soluble peptide. {ECO:0000250|UniProtKB:Q6JAM9}.
Q53FT3	reviewed	HIKES_HUMAN	Protein Hikeshi	HIKESHI C11orf73 HSPC138 HSPC179 HSPC248	Homo sapiens (Human)	197	FUNCTION: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus. {ECO:0000269|PubMed:22541429}.	MISCELLANEOUS: 'Hikeshi' is a traditional Japanese compound word used for a firefighter, smokejumper, or troubleshooter. {ECO:0000305|PubMed:22541429}.	cellular response to heat [GO:0034605]; Golgi organization [GO:0007030]; lung development [GO:0030324]; protein import into nucleus [GO:0006606]; protein transport [GO:0015031]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	Hsp70 protein binding [GO:0030544]; nuclear import signal receptor activity [GO:0061608]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Hsp70 protein binding [GO:0030544]; nuclear import signal receptor activity [GO:0061608]; cellular response to heat [GO:0034605]; Golgi organization [GO:0007030]; lung development [GO:0030324]; protein import into nucleus [GO:0006606]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9DD02}. Cytoplasm, cytosol {ECO:0000269|PubMed:22541429}. Nucleus {ECO:0000269|PubMed:22541429}.
Q53FV1	reviewed	ORML2_HUMAN	ORM1-like protein 2 (Adoplin-2)	ORMDL2 HSPC160 MSTP095	Homo sapiens (Human)	153	FUNCTION: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8N138, ECO:0000269|PubMed:20182505}.		ceramide metabolic process [GO:0006672]; intracellular sphingolipid homeostasis [GO:0090156]; negative regulation of ceramide biosynthetic process [GO:1900060]; sphingolipid biosynthetic process [GO:0030148]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SPOTS complex [GO:0035339]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SPOTS complex [GO:0035339]; ceramide metabolic process [GO:0006672]; intracellular sphingolipid homeostasis [GO:0090156]; negative regulation of ceramide biosynthetic process [GO:1900060]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12093374}; Multi-pass membrane protein {ECO:0000269|PubMed:12093374}.
Q53FZ2	reviewed	ACSM3_HUMAN	Acyl-coenzyme A synthetase ACSM3, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 3) (Butyrate--CoA ligase 3) (Butyryl-coenzyme A synthetase 3) (Middle-chain acyl-CoA synthetase 3) (Propionate--CoA ligase) (EC 6.2.1.17) (Protein SA homolog)	ACSM3 SAH	Homo sapiens (Human)	586	FUNCTION: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11772874). Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms (By similarity). {ECO:0000250|UniProtKB:Q3UNX5, ECO:0000269|PubMed:11772874}.		acyl-CoA metabolic process [GO:0006637]; cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; regulation of blood pressure [GO:0008217]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; butyrate-CoA ligase activity [GO:0047760]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; metal ion binding [GO:0046872]; methylbutanoate-CoA ligase activity [GO:0043759]; propionate CoA-transferase activity [GO:0018729]; propionate-CoA ligase activity [GO:0050218]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; butyrate-CoA ligase activity [GO:0047760]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; metal ion binding [GO:0046872]; methylbutanoate-CoA ligase activity [GO:0043759]; propionate CoA-transferase activity [GO:0018729]; propionate-CoA ligase activity [GO:0050218]; acyl-CoA metabolic process [GO:0006637]; cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; regulation of blood pressure [GO:0008217]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11772874}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q3UNX5}.
Q53G59	reviewed	KLH12_HUMAN	Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)	KLHL12 C3IP1	Homo sapiens (Human)	568	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export (PubMed:27716508). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (PubMed:16547521). The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins (PubMed:18303015, PubMed:20100572, PubMed:27716508). {ECO:0000269|PubMed:16547521, ECO:0000269|PubMed:18303015, ECO:0000269|PubMed:20100572, ECO:0000269|PubMed:22358839, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:27716508}.		COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; protein monoubiquitination [GO:0006513]; Wnt signaling pathway [GO:0016055]	centriolar satellite [GO:0034451]; COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]	identical protein binding [GO:0042802]	centriolar satellite [GO:0034451]; COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; identical protein binding [GO:0042802]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; protein monoubiquitination [GO:0006513]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle {ECO:0000269|PubMed:22358839, ECO:0000269|PubMed:27716508}.
Q53GA4	reviewed	PHLA2_HUMAN	Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C)	PHLDA2 BWR1C HLDA2 IPL TSSC3	Homo sapiens (Human)	152	FUNCTION: Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). {ECO:0000250}.	MISCELLANEOUS: The PHLDA2 locus is imprinted. Loss of imprinting results in overexpression. Imprinting is dependent on RNAi machinery.	animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; regulation of gene expression [GO:0010468]; regulation of glycogen metabolic process [GO:0070873]; regulation of spongiotrophoblast cell proliferation [GO:0060721]	cytoplasm [GO:0005737]; membrane [GO:0016020]	phosphatidylinositol phosphate binding [GO:1901981]	cytoplasm [GO:0005737]; membrane [GO:0016020]; phosphatidylinositol phosphate binding [GO:1901981]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; regulation of gene expression [GO:0010468]; regulation of glycogen metabolic process [GO:0070873]; regulation of spongiotrophoblast cell proliferation [GO:0060721]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q53GD3	reviewed	CTL4_HUMAN	Choline transporter-like protein 4 (Solute carrier family 44 member 4) (Thiamine pyrophosphate transporter 1) (hTPPT1)	SLC44A4 C6orf29 CTL4 NG22 TPPT1 UNQ441/PRO874	Homo sapiens (Human)	710	FUNCTION: Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity) (PubMed:23651124, PubMed:28013291). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed:24379411, PubMed:26741288). {ECO:0000250|UniProtKB:Q7T2B0, ECO:0000269|PubMed:23651124, ECO:0000269|PubMed:24379411, ECO:0000269|PubMed:26741288, ECO:0000269|PubMed:28013291}.; FUNCTION: [Isoform 3]: Has also thiamine pyrophosphate transporter activity. {ECO:0000269|PubMed:24379411}.		acetylcholine biosynthetic process [GO:0008292]; acetylcholine secretion [GO:0061526]; choline transport [GO:0015871]; neuromast hair cell development [GO:0035675]; otolith formation [GO:0032475]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of cell growth [GO:0030307]; thiamine pyrophosphate transmembrane transport [GO:0030974]; transmembrane transport [GO:0055085]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; thiamine pyrophosphate transmembrane transporter activity [GO:0090422]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; thiamine pyrophosphate transmembrane transporter activity [GO:0090422]; acetylcholine biosynthetic process [GO:0008292]; acetylcholine secretion [GO:0061526]; choline transport [GO:0015871]; neuromast hair cell development [GO:0035675]; otolith formation [GO:0032475]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of cell growth [GO:0030307]; thiamine pyrophosphate transmembrane transport [GO:0030974]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24379411, ECO:0000269|PubMed:26828122}; Multi-pass membrane protein {ECO:0000305|PubMed:24379411, ECO:0000305|PubMed:26828122}. Apical cell membrane {ECO:0000269|PubMed:24379411}.
Q53GG5	reviewed	PDLI3_HUMAN	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein)	PDLIM3 ALP	Homo sapiens (Human)	364	FUNCTION: May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}.		actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]	adherens junction [GO:0005912]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]	adherens junction [GO:0005912]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:10063829}. Note=Localizes to myofiber Z-lines.
Q53GL0	reviewed	PKHO1_HUMAN	Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein)	PLEKHO1 CKIP1 OC120 HQ0024c	Homo sapiens (Human)	409	FUNCTION: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}.		lamellipodium morphogenesis [GO:0072673]; myoblast fusion [GO:0007520]; myoblast migration [GO:0051451]; regulation of cell shape [GO:0008360]; regulation of myoblast fusion [GO:1901739]	cytoplasm [GO:0005737]; muscle cell projection membrane [GO:0036195]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]		cytoplasm [GO:0005737]; muscle cell projection membrane [GO:0036195]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; lamellipodium morphogenesis [GO:0072673]; myoblast fusion [GO:0007520]; myoblast migration [GO:0051451]; regulation of cell shape [GO:0008360]; regulation of myoblast fusion [GO:1901739]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10799509, ECO:0000269|PubMed:11827170, ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15254037, ECO:0000269|PubMed:16325375}; Peripheral membrane protein {ECO:0000305|PubMed:14729969}. Nucleus {ECO:0000269|PubMed:10799509, ECO:0000269|PubMed:11827170, ECO:0000269|PubMed:15706351}. Cytoplasm {ECO:0000269|PubMed:15706351}. Note=Predominantly localized to the plasma membrane through the binding to phosphatidylinositol 3-phosphate (PubMed:14729969). In C2C12 cells, with the absence of growth factor, it is found in the nucleus (PubMed:14729969). It rapidly translocates to the plasma membrane after insulin stimulation (PubMed:14729969). In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3 (PubMed:15706351). However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells (Probable). {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000305}.
Q53GL7	reviewed	PAR10_HUMAN	Protein mono-ADP-ribosyltransferase PARP10 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) (Poly [ADP-ribose] polymerase 10) (PARP-10)	PARP10	Homo sapiens (Human)	1025	FUNCTION: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737). {ECO:0000269|PubMed:18851833, ECO:0000269|PubMed:23332125, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:24695737, ECO:0000269|PubMed:25043379}.		chromatin organization [GO:0006325]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; protein auto-ADP-ribosylation [GO:0070213]; protein poly-ADP-ribosylation [GO:0070212]; translesion synthesis [GO:0019985]; viral protein processing [GO:0019082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; transcription corepressor activity [GO:0003714]; chromatin organization [GO:0006325]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; protein auto-ADP-ribosylation [GO:0070213]; protein poly-ADP-ribosylation [GO:0070212]; translesion synthesis [GO:0019985]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15674325}. Cytoplasm {ECO:0000269|PubMed:15674325}. Note=Shuttles between the nuclear and cytoplasmic compartment (PubMed:15674325). A subpopulation concentrates in the nucleolus during late G1/S phase (PubMed:15674325). {ECO:0000269|PubMed:15674325}.
Q53GQ0	reviewed	DHB12_HUMAN	Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1)	HSD17B12 SDR12C1	Homo sapiens (Human)	312	FUNCTION: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16166196}.		estrogen biosynthetic process [GO:0006703]; extracellular matrix organization [GO:0030198]; fatty acid biosynthetic process [GO:0006633]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cell-substrate adhesion [GO:0010811]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; fatty acid elongase complex [GO:0009923]	collagen binding [GO:0005518]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; long-chain-fatty-acyl-CoA reductase activity [GO:0050062]; oxidoreductase activity [GO:0016491]; very-long-chain 3-oxoacyl-CoA reductase activity [GO:0141040]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; fatty acid elongase complex [GO:0009923]; collagen binding [GO:0005518]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; long-chain-fatty-acyl-CoA reductase activity [GO:0050062]; oxidoreductase activity [GO:0016491]; very-long-chain 3-oxoacyl-CoA reductase activity [GO:0141040]; estrogen biosynthetic process [GO:0006703]; extracellular matrix organization [GO:0030198]; fatty acid biosynthetic process [GO:0006633]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cell-substrate adhesion [GO:0010811]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12482854}; Multi-pass membrane protein {ECO:0000269|PubMed:12482854}.
Q53GS7	reviewed	GLE1_HUMAN	mRNA export factor GLE1 (hGLE1) (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1)	GLE1 GLE1L	Homo sapiens (Human)	698	FUNCTION: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). {ECO:0000269|PubMed:12668658, ECO:0000269|PubMed:16000379, ECO:0000269|PubMed:9618489}.	MISCELLANEOUS: [Isoform 1]: Major isoform.	mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nucleolus [GO:0005730]	identical protein binding [GO:0042802]; inositol hexakisphosphate binding [GO:0000822]; phospholipid binding [GO:0005543]; translation initiation factor binding [GO:0031369]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nucleolus [GO:0005730]; identical protein binding [GO:0042802]; inositol hexakisphosphate binding [GO:0000822]; phospholipid binding [GO:0005543]; translation initiation factor binding [GO:0031369]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12668658}. Cytoplasm {ECO:0000269|PubMed:12668658}. Note=Shuttles between the nucleus and the cytoplasm (PubMed:12668658). Shuttling is essential for its mRNA export function (PubMed:12668658). {ECO:0000269|PubMed:12668658}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:12668658}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:12668658}. Note=Shuttles between the nucleus and the cytoplasm (PubMed:12668658). In the nucleus, isoform 1 localizes to the nuclear pore complex and nuclear envelope (PubMed:12668658). Shuttling is essential for its mRNA export function (PubMed:12668658). {ECO:0000269|PubMed:12668658}.
Q53GS9	reviewed	UBP39_HUMAN	Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein)	USP39 CGI-21 HSPC332 PRO2855	Homo sapiens (Human)	565	FUNCTION: Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:33127822, PubMed:34614178). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint (PubMed:18728397). Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 (PubMed:30771428). Plays also an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair (PubMed:34614178). Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (PubMed:33127822). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (PubMed:36651806). {ECO:0000250|UniProtKB:Q3TIX9, ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:18728397, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:30771428, ECO:0000269|PubMed:33127822, ECO:0000269|PubMed:34614178, ECO:0000269|PubMed:36651806}.		cell cycle [GO:0007049]; cell division [GO:0051301]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; cell division [GO:0051301]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:33127822, ECO:0000269|PubMed:34614178}.
Q53GT1	reviewed	KLH22_HUMAN	Kelch-like protein 22	KLHL22	Homo sapiens (Human)	634	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation (PubMed:19995937, PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy (PubMed:29769719). {ECO:0000269|PubMed:19995937, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:29769719}.	MISCELLANEOUS: Potential oncogene that is up-regulated in breast cancer cells and promotes tumor growth. {ECO:0000269|PubMed:29769719}.	cell division [GO:0051301]; cellular response to amino acid stimulus [GO:0071230]; cellular response to leucine [GO:0071233]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of autophagy [GO:0010507]; negative regulation of type I interferon production [GO:0032480]; positive regulation of cell growth [GO:0030307]; positive regulation of TORC1 signaling [GO:1904263]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; ubiquitin-dependent protein catabolic process [GO:0006511]	centrosome [GO:0005813]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; polar microtubule [GO:0005827]	14-3-3 protein binding [GO:0071889]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	centrosome [GO:0005813]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; polar microtubule [GO:0005827]; 14-3-3 protein binding [GO:0071889]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; cell division [GO:0051301]; cellular response to amino acid stimulus [GO:0071230]; cellular response to leucine [GO:0071233]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of autophagy [GO:0010507]; negative regulation of type I interferon production [GO:0032480]; positive regulation of cell growth [GO:0030307]; positive regulation of TORC1 signaling [GO:1904263]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:29769719}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23455478}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23455478}. Nucleus {ECO:0000269|PubMed:29769719}. Lysosome {ECO:0000269|PubMed:29769719}. Note=Mainly cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase (PubMed:23455478). Localizes to the nucleus upon amino acid starvation (PubMed:29769719). Relocalizes to the cytosol and associates with lysosomes when amino acids are available (PubMed:29769719). {ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:29769719}.
Q53H12	reviewed	AGK_HUMAN	Acylglycerol kinase, mitochondrial (hAGK) (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) (HsMuLK) (MuLK) (Multi-substrate lipid kinase)	AGK MULK	Homo sapiens (Human)	422	FUNCTION: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15939762). Does not phosphorylate sphingosine (PubMed:15939762). Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed:28712724, PubMed:28712726). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed:28712724, PubMed:28712726). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed:28712724). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (PubMed:15939762). {ECO:0000250|UniProtKB:Q9ESW4, ECO:0000269|PubMed:15939762, ECO:0000269|PubMed:28712724, ECO:0000269|PubMed:28712726}.		ceramide biosynthetic process [GO:0046513]; glycerolipid metabolic process [GO:0046486]; lipid phosphorylation [GO:0046834]; protein insertion into mitochondrial inner membrane [GO:0045039]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]	acylglycerol kinase activity [GO:0047620]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; ceramide kinase activity [GO:0001729]; dihydroceramide kinase activity [GO:0102773]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]; acylglycerol kinase activity [GO:0047620]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; ceramide kinase activity [GO:0001729]; dihydroceramide kinase activity [GO:0102773]; ceramide biosynthetic process [GO:0046513]; glycerolipid metabolic process [GO:0046486]; lipid phosphorylation [GO:0046834]; protein insertion into mitochondrial inner membrane [GO:0045039]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:15939762, ECO:0000269|PubMed:16269826, ECO:0000269|PubMed:28712724, ECO:0000269|PubMed:28712726}; Peripheral membrane protein {ECO:0000269|PubMed:28712724}. Mitochondrion intermembrane space {ECO:0000269|PubMed:28712724, ECO:0000269|PubMed:28712726}. Note=Localizes in the mitochondrion intermembrane space, where it associates with the inner membrane (PubMed:28712724). It is unclear whether the N-terminal hydrophobic region forms a transmembrane region or associates with the membrane without crossing it (PubMed:28712724, PubMed:28712726). {ECO:0000269|PubMed:28712724, ECO:0000269|PubMed:28712726}.
Q53H47	reviewed	SETMR_HUMAN	Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion protein) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.357); Transposon Hsmar1 transposase (EC 3.1.-.-)]	SETMAR	Homo sapiens (Human)	684	FUNCTION: Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750). {ECO:0000269|PubMed:16332963, ECO:0000269|PubMed:16672366, ECO:0000269|PubMed:17403897, ECO:0000269|PubMed:17877369, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:20457750, ECO:0000269|PubMed:20521842, ECO:0000269|PubMed:21187428, ECO:0000269|PubMed:22231448, ECO:0000269|PubMed:24573677, ECO:0000303|PubMed:18263876}.	MISCELLANEOUS: The mariner transposase region in only present in primates and appeared 40-58 million years ago, after the insertion of a transposon downstream of a preexisting SET gene, followed by the de novo exonization of previously non-coding sequence and the creation of a new intron.	cell population proliferation [GO:0008283]; DNA catabolic process [GO:0006308]; DNA double-strand break processing [GO:0000729]; DNA integration [GO:0015074]; double-strand break repair via nonhomologous end joining [GO:0006303]; methylation [GO:0032259]; mitotic DNA integrity checkpoint signaling [GO:0044774]; negative regulation of chromosome organization [GO:2001251]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; replication fork processing [GO:0031297]	nucleolus [GO:0005730]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	DNA binding [GO:0003677]; DNA topoisomerase binding [GO:0044547]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; protein homodimerization activity [GO:0042803]; single-stranded DNA binding [GO:0003697]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; DNA binding [GO:0003677]; DNA topoisomerase binding [GO:0044547]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; protein homodimerization activity [GO:0042803]; single-stranded DNA binding [GO:0003697]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; zinc ion binding [GO:0008270]; cell population proliferation [GO:0008283]; DNA catabolic process [GO:0006308]; DNA double-strand break processing [GO:0000729]; DNA integration [GO:0015074]; double-strand break repair via nonhomologous end joining [GO:0006303]; methylation [GO:0032259]; mitotic DNA integrity checkpoint signaling [GO:0044774]; negative regulation of chromosome organization [GO:2001251]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; replication fork processing [GO:0031297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18263876}. Chromosome {ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22231448}. Note=Recruited on damaged DNA at sites of double-strand breaks. {ECO:0000269|PubMed:18263876}.
Q53H54	reviewed	TYW2_HUMAN	tRNA wybutosine-synthesizing protein 2 homolog (tRNA-yW-synthesizing protein 2) (EC 2.5.1.114) (tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase)	TRMT12 TRM12 TYW2	Homo sapiens (Human)	448	FUNCTION: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. {ECO:0000269|PubMed:22761755}.		tRNA methylation [GO:0030488]; wybutosine biosynthetic process [GO:0031591]	cytoplasm [GO:0005737]	S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity [GO:0102522]; tRNA methyltransferase activity [GO:0008175]	cytoplasm [GO:0005737]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity [GO:0102522]; tRNA methyltransferase activity [GO:0008175]; tRNA methylation [GO:0030488]; wybutosine biosynthetic process [GO:0031591]	
Q53H76	reviewed	PLA1A_HUMAN	Phospholipase A1 member A (EC 3.1.1.111) (Phosphatidylserine-specific phospholipase A1) (PS-PLA1)	PLA1A NMD PSPLA1	Homo sapiens (Human)	456	FUNCTION: Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (PubMed:10196188). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (By similarity). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity). {ECO:0000250|UniProtKB:P97535, ECO:0000269|PubMed:10196188}.; FUNCTION: [Isoform 2]: Hydrolyzes lyso-PS but not PS. {ECO:0000269|PubMed:10196188}.		lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phosphatidylserine metabolic process [GO:0006658]	acrosomal membrane [GO:0002080]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	lipase activity [GO:0016298]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]	acrosomal membrane [GO:0002080]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lipase activity [GO:0016298]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phosphatidylserine metabolic process [GO:0006658]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P97535}.
Q53H80	reviewed	AKIR2_HUMAN	Akirin-2	AKIRIN2 C6orf166	Homo sapiens (Human)	203	FUNCTION: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). {ECO:0000250|UniProtKB:B1AXD8, ECO:0000269|PubMed:34711951}.	MISCELLANEOUS: 'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal. {ECO:0000305|PubMed:18066067}.	adaptive immune response [GO:0002250]; cerebral cortex development [GO:0021987]; defense response to bacterium [GO:0042742]; embryo development ending in birth or egg hatching [GO:0009792]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of B cell activation [GO:0050871]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome localization [GO:0031144]; protein import into nucleus [GO:0006606]; regulation of muscle cell differentiation [GO:0051147]; response to lipopolysaccharide [GO:0032496]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; transcription coregulator activity [GO:0003712]; adaptive immune response [GO:0002250]; cerebral cortex development [GO:0021987]; defense response to bacterium [GO:0042742]; embryo development ending in birth or egg hatching [GO:0009792]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of B cell activation [GO:0050871]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome localization [GO:0031144]; protein import into nucleus [GO:0006606]; regulation of muscle cell differentiation [GO:0051147]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18066067, ECO:0000269|PubMed:34711951}. Cytoplasm {ECO:0000250|UniProtKB:B1AXD8}. Membrane {ECO:0000250|UniProtKB:B1AXD8}. Note=Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions. {ECO:0000250|UniProtKB:B1AXD8}.
Q53H82	reviewed	LACB2_HUMAN	Endoribonuclease LACTB2 (EC 3.1.27.-) (Beta-lactamase-like protein 2)	LACTB2 CGI-83	Homo sapiens (Human)	288	FUNCTION: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. {ECO:0000269|PubMed:26826708}.	MISCELLANEOUS: RNAi-mediated down-regulation results in rapid cell death. The reason for this is not clear; there are only minor changes in mitochondrial mRNA levels. {ECO:0000269|PubMed:26826708}.		mitochondrial matrix [GO:0005759]	RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:26826708}.
Q53H96	reviewed	P5CR3_HUMAN	Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein)	PYCR3 PYCRL	Homo sapiens (Human)	274	FUNCTION: Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. {ECO:0000269|PubMed:23024808}.		L-proline biosynthetic process [GO:0055129]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]	pyrroline-5-carboxylate reductase activity [GO:0004735]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; pyrroline-5-carboxylate reductase activity [GO:0004735]; L-proline biosynthetic process [GO:0055129]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23024808}.
Q53HC0	reviewed	CCD92_HUMAN	Coiled-coil domain-containing protein 92 (Limkain beta-2)	CCDC92	Homo sapiens (Human)	331	FUNCTION: Interferon-stimulated protein that plays a role in innate immunity. Strongly inhibits ebolavirus transcription and replication. Forms a complex with viral RNA-bound nucleocapsid NP and thereby prevents the transport of NP to the cell surface. {ECO:0000269|PubMed:32528005}.		innate immune response [GO:0045087]; regulation of defense response to virus [GO:0050688]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; innate immune response [GO:0045087]; regulation of defense response to virus [GO:0050688]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22863007}. Cytoplasm {ECO:0000269|PubMed:32528005}.
Q53HC9	reviewed	EIPR1_HUMAN	EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein)	EIPR1 TSSC1	Homo sapiens (Human)	387	FUNCTION: Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein(PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity). {ECO:0000250|UniProtKB:Q5PPK9, ECO:0000269|PubMed:27440922}.		endocytic recycling [GO:0032456]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of retrograde transport, endosome to Golgi [GO:1905281]; protein ubiquitination [GO:0016567]; regulation of insulin secretion [GO:0050796]	trans-Golgi network [GO:0005802]		trans-Golgi network [GO:0005802]; endocytic recycling [GO:0032456]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of retrograde transport, endosome to Golgi [GO:1905281]; protein ubiquitination [GO:0016567]; regulation of insulin secretion [GO:0050796]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:27440922}.
Q53HI1	reviewed	UNC50_HUMAN	Protein unc-50 homolog (Periodontal ligament-specific protein 22) (PDLs22) (Protein GMH1 homolog) (hGMH1) (Uncoordinated-like protein)	UNC50 UNCL HSD-23 HSD23	Homo sapiens (Human)	259	FUNCTION: Involved in the cell surface expression of neuronal nicotinic receptors (By similarity). Binds RNA (By similarity). {ECO:0000250|UniProtKB:O55227}.		protein localization to cell surface [GO:0034394]	Golgi membrane [GO:0000139]; nuclear inner membrane [GO:0005637]	RNA binding [GO:0003723]	Golgi membrane [GO:0000139]; nuclear inner membrane [GO:0005637]; RNA binding [GO:0003723]; protein localization to cell surface [GO:0034394]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:O55227}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O55227}. Golgi apparatus membrane {ECO:0000269|PubMed:12808035}; Multi-pass membrane protein {ECO:0000269|PubMed:12808035}.
Q53HL2	reviewed	BOREA_HUMAN	Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein)	CDCA8 PESCRG3	Homo sapiens (Human)	280	FUNCTION: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}.	MISCELLANEOUS: Cells lacking CDCA8 display a slight decrease in histone H3 'Ser-10' phosphorylation, suggesting that the CPC complex mediates phosphorylation of 'Ser-10' of histone H3.	chromosome organization [GO:0051276]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of protein phosphorylation [GO:0001934]	chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; spindle midzone [GO:0051233]		chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; spindle midzone [GO:0051233]; chromosome organization [GO:0051276]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of protein phosphorylation [GO:0001934]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:18946085}. Cytoplasm {ECO:0000269|PubMed:18946085}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15561729}. Chromosome, centromere {ECO:0000269|PubMed:20739936}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. {ECO:0000269|PubMed:18946085}.
Q53HV7	reviewed	SMUG1_HUMAN	Single-strand selective monofunctional uracil DNA glycosylase (EC 3.2.2.-)	SMUG1	Homo sapiens (Human)	270	FUNCTION: Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. {ECO:0000269|PubMed:10074426, ECO:0000269|PubMed:11526119, ECO:0000269|PubMed:12161446, ECO:0000269|PubMed:12718543}.		base-excision repair [GO:0006284]; depyrimidination [GO:0045008]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]; identical protein binding [GO:0042802]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]; single-strand selective uracil DNA N-glycosylase activity [GO:0017065]; uracil DNA N-glycosylase activity [GO:0004844]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]; identical protein binding [GO:0042802]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]; single-strand selective uracil DNA N-glycosylase activity [GO:0017065]; uracil DNA N-glycosylase activity [GO:0004844]; base-excision repair [GO:0006284]; depyrimidination [GO:0045008]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10074426, ECO:0000269|PubMed:12161446}.
Q53QV2	reviewed	LBH_HUMAN	Protein LBH (hLBH) (Limb bud and heart development protein homolog)	LBH	Homo sapiens (Human)	105	FUNCTION: Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway. {ECO:0000269|PubMed:17390236}.		mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of stem cell differentiation [GO:2000737]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mammary stem cell proliferation [GO:2000103]; positive regulation of somatic stem cell division [GO:1904677]; positive regulation of somatic stem cell population maintenance [GO:1904674]; regulation of MAPK cascade [GO:0043408]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of stem cell differentiation [GO:2000737]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mammary stem cell proliferation [GO:2000103]; positive regulation of somatic stem cell division [GO:1904677]; positive regulation of somatic stem cell population maintenance [GO:1904674]; regulation of MAPK cascade [GO:0043408]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17390236}. Cytoplasm {ECO:0000269|PubMed:17390236}.
Q53QZ3	reviewed	RHG15_HUMAN	Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15)	ARHGAP15 BM-024 BM-030 BM-046	Homo sapiens (Human)	475	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}.		regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12650940}. Membrane {ECO:0000269|PubMed:12650940}; Peripheral membrane protein {ECO:0000269|PubMed:12650940}.
Q53R12	reviewed	T4S20_HUMAN	Transmembrane 4 L6 family member 20	TM4SF20 UNQ518/PRO994	Homo sapiens (Human)	229	FUNCTION: Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293). {ECO:0000269|PubMed:25310401, ECO:0000269|PubMed:27499293}.		negative regulation of proteolysis [GO:0045861]	endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]		endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; negative regulation of proteolysis [GO:0045861]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:23810381}; Multi-pass membrane protein {ECO:0000269|PubMed:23810381}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25310401}; Multi-pass membrane protein {ECO:0000269|PubMed:25310401}. Note=Ceramide alters the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20. {ECO:0000269|PubMed:27499293}.
Q53R41	reviewed	FAKD1_HUMAN	FAST kinase domain-containing protein 1, mitochondrial	FASTKD1 KIAA1800	Homo sapiens (Human)	847	FUNCTION: Involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity. {ECO:0000269|PubMed:28238724, ECO:0000269|PubMed:28335001}.		mitochondrial RNA metabolic process [GO:0000959]; mitochondrial RNA processing [GO:0000963]; regulation of mitochondrial mRNA stability [GO:0044528]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]	RNA binding [GO:0003723]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]; RNA binding [GO:0003723]; mitochondrial RNA metabolic process [GO:0000959]; mitochondrial RNA processing [GO:0000963]; regulation of mitochondrial mRNA stability [GO:0044528]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:28238724, ECO:0000269|PubMed:28335001}. Note=Preferentially localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly (PubMed:28335001). {ECO:0000269|PubMed:28335001}.
Q53RT3	reviewed	APRV1_HUMAN	Retroviral-like aspartic protease 1 (EC 3.4.23.-) (Skin-specific retroviral-like aspartic protease) (SASPase) (Skin aspartic protease) (TPA-inducible aspartic proteinase-like protein) (TAPS)	ASPRV1 SASP	Homo sapiens (Human)	343	FUNCTION: Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization. {ECO:0000269|PubMed:32516568}.		protein processing [GO:0016485]; skin development [GO:0043588]	membrane [GO:0016020]	aspartic-type endopeptidase activity [GO:0004190]	membrane [GO:0016020]; aspartic-type endopeptidase activity [GO:0004190]; protein processing [GO:0016485]; skin development [GO:0043588]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q53S33	reviewed	BOLA3_HUMAN	BolA-like protein 3	BOLA3	Homo sapiens (Human)	107	FUNCTION: Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1 (PubMed:27532772). {ECO:0000250|UniProtKB:P39724, ECO:0000305|PubMed:27532772}.		cell redox homeostasis [GO:0045454]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]	cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]		cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; cell redox homeostasis [GO:0045454]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22746225}.
Q53T94	reviewed	TAF1B_HUMAN	TATA box-binding protein-associated factor RNA polymerase I subunit B (RNA polymerase I-specific TBP-associated factor 63 kDa) (TAFI63) (TATA box-binding protein-associated factor 1B) (TBP-associated factor 1B) (Transcription initiation factor SL1/TIF-IB subunit B)	TAF1B	Homo sapiens (Human)	588	FUNCTION: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:21921198, ECO:0000269|PubMed:21921199, ECO:0000269|PubMed:7491500, ECO:0000269|PubMed:7801123, ECO:0000269|PubMed:7801130}.		DNA-templated transcription [GO:0006351]; nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; RNA polymerase I preinitiation complex assembly [GO:0001188]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I core factor complex [GO:0070860]; RNA polymerase transcription factor SL1 complex [GO:0005668]	metal ion binding [GO:0046872]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; TBP-class protein binding [GO:0017025]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I core factor complex [GO:0070860]; RNA polymerase transcription factor SL1 complex [GO:0005668]; metal ion binding [GO:0046872]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; TBP-class protein binding [GO:0017025]; DNA-templated transcription [GO:0006351]; nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; RNA polymerase I preinitiation complex assembly [GO:0001188]	SUBCELLULAR LOCATION: Nucleus, nucleolus.
Q53TN4	reviewed	CYBR1_HUMAN	Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3)	CYBRD1 DCYTB FRRS3	Homo sapiens (Human)	286	FUNCTION: Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:30272000). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed:30272000). It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337). May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity). {ECO:0000250|UniProtKB:Q925G2, ECO:0000269|PubMed:17068337, ECO:0000269|PubMed:30272000, ECO:0000305|PubMed:16510471}.		ascorbate homeostasis [GO:0140576]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; reductive iron assimilation [GO:0033215]; response to iron ion [GO:0010039]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on metal ions [GO:0016722]; transmembrane ascorbate ferrireductase activity [GO:0140571]; transmembrane monodehydroascorbate reductase activity [GO:0140575]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on metal ions [GO:0016722]; transmembrane ascorbate ferrireductase activity [GO:0140571]; transmembrane monodehydroascorbate reductase activity [GO:0140575]; ascorbate homeostasis [GO:0140576]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; reductive iron assimilation [GO:0033215]; response to iron ion [GO:0010039]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17068337}; Multi-pass membrane protein {ECO:0000269|PubMed:30272000}. Apical cell membrane {ECO:0000305|PubMed:12949720}; Multi-pass membrane protein {ECO:0000269|PubMed:30272000}. Note=Localized at the brush border of duodenal cells. {ECO:0000269|PubMed:12949720}.
Q53TQ3	reviewed	IN80D_HUMAN	INO80 complex subunit D	INO80D	Homo sapiens (Human)	1027	FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.		chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18922472}.
Q53TS8	reviewed	CTSRT_HUMAN	Cation channel sperm-associated targeting subunit tau (CatSper-tau) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein) (C2 calcium-dependent domain-containing protein 6)	C2CD6 ALS2CR11 CATSPERT	Homo sapiens (Human)	1820	FUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CatSper complex targeting and trafficking into the quadrilinear nanodomains. Targets the preassembled CatSper complexes to elongating flagella, where it links the channel-carrying vesicles and motor proteins. {ECO:0000250|UniProtKB:A0A5F8MPU3}.		flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]; vesicle-mediated transport to the plasma membrane [GO:0098876]	CatSper complex [GO:0036128]; sperm principal piece [GO:0097228]		CatSper complex [GO:0036128]; sperm principal piece [GO:0097228]; flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]; vesicle-mediated transport to the plasma membrane [GO:0098876]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:E9Q9F6}. Note=Specifically located in the principal piece of sperm tail. {ECO:0000250|UniProtKB:E9Q9F6}.
Q562E7	reviewed	WDR81_HUMAN	WD repeat-containing protein 81	WDR81	Homo sapiens (Human)	1941	FUNCTION: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}.		aggrephagy [GO:0035973]; early endosome to late endosome transport [GO:0045022]; mitochondrion organization [GO:0007005]; protein stabilization [GO:0050821]; ubiquitin-dependent protein catabolic process [GO:0006511]	autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]	autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; aggrephagy [GO:0035973]; early endosome to late endosome transport [GO:0045022]; mitochondrion organization [GO:0007005]; protein stabilization [GO:0050821]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}; Peripheral membrane protein {ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}. Late endosome membrane {ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. Lysosome membrane {ECO:0000269|PubMed:27126989}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:28404643}. Mitochondrion {ECO:0000269|PubMed:28404643}. Cytoplasm, cytosol {ECO:0000269|PubMed:27126989}.
Q562F6	reviewed	SGO2_HUMAN	Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin)	SGO2 SGOL2	Homo sapiens (Human)	1265	FUNCTION: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}.	MISCELLANEOUS: Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin).	cell division [GO:0051301]; chromosome segregation [GO:0007059]; meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic cohesin complex [GO:0030892]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]		chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic cohesin complex [GO:0030892]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:17485487}. Chromosome, centromere {ECO:0000269|PubMed:17485487}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q7TSY8}. Note=During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity). SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (By similarity). During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity). In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase (PubMed:17485487). Centromeric localization requires the presence of BUB1 and AUKRB (PubMed:17485487). {ECO:0000250|UniProtKB:Q7TSY8, ECO:0000269|PubMed:17485487}.
Q567U6	reviewed	CCD93_HUMAN	Coiled-coil domain-containing protein 93	CCDC93	Homo sapiens (Human)	631	FUNCTION: Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:28892079, PubMed:25355947). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947). {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.; FUNCTION: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}.		endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031]	early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]		early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Early endosome {ECO:0000305|PubMed:25355947}.
Q569K4	reviewed	Z385B_HUMAN	Zinc finger protein 385B (Zinc finger protein 533)	ZNF385B ZNF533	Homo sapiens (Human)	471	FUNCTION: May play a role in p53/TP53-mediated apoptosis. {ECO:0000269|PubMed:22945289}.	MISCELLANEOUS: [Isoform 2]: Major isoform in tonsil. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Major isoform in lymph node. {ECO:0000305}.	intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]	nucleus [GO:0005634]	nucleic acid binding [GO:0003676]; p53 binding [GO:0002039]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; p53 binding [GO:0002039]; zinc ion binding [GO:0008270]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22945289}.
Q56NI9	reviewed	ESCO2_HUMAN	N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2)	ESCO2	Homo sapiens (Human)	601	FUNCTION: Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}.		chromosome segregation [GO:0007059]; double-strand break repair [GO:0006302]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic sister chromatid cohesion [GO:0007064]; post-translational protein acetylation [GO:0034421]; protein localization to chromatin [GO:0071168]; regulation of DNA replication [GO:0006275]	cell junction [GO:0030054]; chromatin [GO:0000785]; chromocenter [GO:0010369]; chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of double-strand break [GO:0035861]; XY body [GO:0001741]	acetyltransferase activity [GO:0016407]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; metal ion binding [GO:0046872]; N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733]	cell junction [GO:0030054]; chromatin [GO:0000785]; chromocenter [GO:0010369]; chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of double-strand break [GO:0035861]; XY body [GO:0001741]; acetyltransferase activity [GO:0016407]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; metal ion binding [GO:0046872]; N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; chromosome segregation [GO:0007059]; double-strand break repair [GO:0006302]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic sister chromatid cohesion [GO:0007064]; post-translational protein acetylation [GO:0034421]; protein localization to chromatin [GO:0071168]; regulation of DNA replication [GO:0006275]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496}. Chromosome {ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496}. Note=Nuclear in interphase cells, excluded from chromosomes during metaphase but reassociates with chromosomes in telophase. {ECO:0000269|PubMed:15958495}.
Q56P03	reviewed	EAPP_HUMAN	E2F-associated phosphoprotein (EAPP)	EAPP C14orf11 BM-036	Homo sapiens (Human)	285	FUNCTION: May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. {ECO:0000269|PubMed:15716352}.		negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q56P42	reviewed	PYDC2_HUMAN	Pyrin domain-containing protein 2 (Pyrin-only protein 2) (cellular POP2) (cPOP2)	PYDC2 POP2	Homo sapiens (Human)	97	FUNCTION: May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (PubMed:17339483, PubMed:17178784). May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA (PubMed:17339483, PubMed:24871464). {ECO:0000269|PubMed:17178784, ECO:0000269|PubMed:17339483, ECO:0000269|PubMed:24871464}.		inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17178784, ECO:0000269|PubMed:17339483}. Nucleus {ECO:0000269|PubMed:17178784, ECO:0000269|PubMed:17339483}. Note=Recruited to specks formed by PYCARD within the cytoplasm. {ECO:0000269|PubMed:17178784}.
Q56UN5	reviewed	M3K19_HUMAN	Mitogen-activated protein kinase kinase kinase 19 (EC 2.7.11.1) (Regulated in COPD, protein kinase) (SPS1/STE20-related protein kinase YSK4)	MAP3K19 RCK YSK4	Homo sapiens (Human)	1328			phosphorylation [GO:0016310]		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	
Q587J8	reviewed	KHDC3_HUMAN	KH domain-containing protein 3 (ES cell-associated transcript 1 protein) (KHDC3-like protein)	KHDC3L C6orf221 ECAT1	Homo sapiens (Human)	217	FUNCTION: As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Regulates homologous recombination-mediated DNA repair via recruitment of RAD51 to sites of DNA double-strand breaks, and sustainment of PARP1 activity, which in turn modulates downstream ATM or ATR activation (PubMed:31609975). Activation of ATM or ATR in response to DNA double-strand breaks may be cell-type specific (By similarity). Its role in DNA double-strand break repair is independent of its role in restarting stalled replication forks (By similarity). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for maintenance of euploidy during cleavage-stage embryogenesis (By similarity). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process (By similarity). Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity). Promotes neural stem cell neurogenesis and neuronal differentiation in the hippocampus (By similarity). May regulate normal development of learning, memory and anxiety (By similarity). Capable of binding RNA (By similarity). {ECO:0000250|UniProtKB:F6SZT2, ECO:0000250|UniProtKB:Q9CWU5, ECO:0000269|PubMed:31609975}.		actin filament organization [GO:0007015]; establishment of organelle localization [GO:0051656]; negative regulation of apoptotic process [GO:0043066]; positive regulation of dendrite development [GO:1900006]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of embryonic development [GO:0040019]; positive regulation of neurogenesis [GO:0050769]; regulation of protein localization [GO:0032880]; replication fork processing [GO:0031297]	cell cortex [GO:0005938]; centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; subcortical maternal complex [GO:0106333]	RNA binding [GO:0003723]	cell cortex [GO:0005938]; centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; subcortical maternal complex [GO:0106333]; RNA binding [GO:0003723]; actin filament organization [GO:0007015]; establishment of organelle localization [GO:0051656]; negative regulation of apoptotic process [GO:0043066]; positive regulation of dendrite development [GO:1900006]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of embryonic development [GO:0040019]; positive regulation of neurogenesis [GO:0050769]; regulation of protein localization [GO:0032880]; replication fork processing [GO:0031297]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:25542835}. Nucleus {ECO:0000269|PubMed:25542835, ECO:0000269|PubMed:31609975}. Mitochondrion {ECO:0000250|UniProtKB:Q9CWU5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9CWU5}. Chromosome {ECO:0000269|PubMed:31609975}. Note=Localized to centrosomes during interphase and mitosis (By similarity). Localizes to sites of DNA double-strand break repair (PubMed:31609975). {ECO:0000250|UniProtKB:Q9CWU5, ECO:0000269|PubMed:31609975}.
Q58A45	reviewed	PAN3_HUMAN	PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3)	PAN3	Homo sapiens (Human)	887	FUNCTION: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decapping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.; FUNCTION: [Isoform 1]: Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway (PubMed:28559491). Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A (PubMed:28559491). {ECO:0000269|PubMed:28559491}.; FUNCTION: [Isoform 3]: Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD) (PubMed:28559491). Its activity is required for efficient P-body formation (PubMed:28559491). May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation (PubMed:28559491). {ECO:0000269|PubMed:28559491}.		mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]	cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; PAN complex [GO:0031251]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) binding [GO:0008143]; protein kinase activity [GO:0004672]	cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; PAN complex [GO:0031251]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) binding [GO:0008143]; protein kinase activity [GO:0004672]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:18625844}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus {ECO:0000269|PubMed:28559491}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000269|PubMed:28559491}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:28559491}.
Q58DX5	reviewed	NADL2_HUMAN	Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2)	NAALADL2	Homo sapiens (Human)	795	FUNCTION: May be catalytically inactive.	MISCELLANEOUS: The gene maps to 3q26.31, a region associated with Cornelia de Lange syndrome. However, PubMed:15168106 failed to identify specific mutations in a panel of DNA samples from patients with Cornelia de Lange syndrome.	response to bacterium [GO:0009617]	membrane [GO:0016020]; nucleoplasm [GO:0005654]		membrane [GO:0016020]; nucleoplasm [GO:0005654]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q58EX2	reviewed	SDK2_HUMAN	Protein sidekick-2	SDK2 KIAA1514	Homo sapiens (Human)	2172	FUNCTION: Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}.		camera-type eye photoreceptor cell differentiation [GO:0060219]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416]	plasma membrane [GO:0005886]; synapse [GO:0045202]		plasma membrane [GO:0005886]; synapse [GO:0045202]; camera-type eye photoreceptor cell differentiation [GO:0060219]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8AV57}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8AV57}. Synapse {ECO:0000250|UniProtKB:Q6V4S5}.
Q58EX7	reviewed	PKHG4_HUMAN	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1)	PLEKHG4 PRTPHN1	Homo sapiens (Human)	1191	FUNCTION: Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.		axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056]	
Q58F21	reviewed	BRDT_HUMAN	Bromodomain testis-specific protein (Cancer/testis antigen 9) (CT9) (RING3-like protein)	BRDT	Homo sapiens (Human)	947	FUNCTION: Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:22464331, PubMed:22901802). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time (PubMed:22901802). In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802). Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (By similarity). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (By similarity). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. {ECO:0000250|UniProtKB:Q91Y44, ECO:0000269|PubMed:15647849, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:22901802, ECO:0000269|PubMed:9367677}.	MISCELLANEOUS: BRDT is a promising target for male contraception. Inhibition by thienodiazepine inhibitor (+)-JQ1 that binds Asn-109, prevents recognition of acetylated histone H4, causing a complete and reversible contraceptive effect in male mice (PubMed:22901802). {ECO:0000305|PubMed:22901802}.	chromatin remodeling [GO:0006338]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; mRNA processing [GO:0006397]; positive regulation of transcription involved in meiotic cell cycle [GO:0051039]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; sperm DNA condensation [GO:0035092]	nucleus [GO:0005634]	histone binding [GO:0042393]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; transcription coactivator activity [GO:0003713]	nucleus [GO:0005634]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; transcription coactivator activity [GO:0003713]; chromatin remodeling [GO:0006338]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; mRNA processing [GO:0006397]; positive regulation of transcription involved in meiotic cell cycle [GO:0051039]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; sperm DNA condensation [GO:0035092]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20538714, ECO:0000269|PubMed:22901802, ECO:0000269|PubMed:22971749, ECO:0000269|PubMed:25593309}. Note=Detected on chromatin. {ECO:0000250|UniProtKB:Q91Y44}.
Q58HT5	reviewed	AWAT1_HUMAN	Acyl-CoA wax alcohol acyltransferase 1 (EC 2.3.1.75) (Diacylglycerol O-acyltransferase 2-like protein 3) (Diacylglycerol acyltransferase 2) (Long-chain-alcohol O-fatty-acyltransferase 1)	AWAT1 DGA2 DGAT2L3	Homo sapiens (Human)	328	FUNCTION: Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15671038). Shows a strong preference for decyl alcohol (C10), with less activity towards C16 and C18 alcohols (PubMed:15671038). Shows a strong preference for saturated acyl-CoAs (PubMed:15671038). {ECO:0000269|PubMed:15671038}.		arachidonic acid metabolic process [GO:0019369]; lipid metabolic process [GO:0006629]; wax biosynthetic process [GO:0010025]	endoplasmic reticulum membrane [GO:0005789]	arachidoyl-CoA:1-dodecanol O-acyltransferase activity [GO:0102966]; long-chain-alcohol O-fatty-acyltransferase activity [GO:0047196]	endoplasmic reticulum membrane [GO:0005789]; arachidoyl-CoA:1-dodecanol O-acyltransferase activity [GO:0102966]; long-chain-alcohol O-fatty-acyltransferase activity [GO:0047196]; arachidonic acid metabolic process [GO:0019369]; lipid metabolic process [GO:0006629]; wax biosynthetic process [GO:0010025]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6E213}; Multi-pass membrane protein {ECO:0000255}.
Q58WW2	reviewed	DCAF6_HUMAN	DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP)	DCAF6 IQWD1 MSTP055	Homo sapiens (Human)	860	FUNCTION: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear receptor coactivator activity [GO:0030374]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear receptor coactivator activity [GO:0030374]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15784617}.
Q59EK9	reviewed	RUN3A_HUMAN	RUN domain-containing protein 3A (Rap2-interacting protein 8) (RPIP-8)	RUNDC3A RAP2IP RPIP8	Homo sapiens (Human)	446	FUNCTION: May act as an effector of RAP2A in neuronal cells. {ECO:0000250}.		positive regulation of cGMP-mediated signaling [GO:0010753]; small GTPase mediated signal transduction [GO:0007264]	intracellular membrane-bounded organelle [GO:0043231]	GTPase regulator activity [GO:0030695]	intracellular membrane-bounded organelle [GO:0043231]; GTPase regulator activity [GO:0030695]; positive regulation of cGMP-mediated signaling [GO:0010753]; small GTPase mediated signal transduction [GO:0007264]	
Q59H18	reviewed	TNI3K_HUMAN	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase)	TNNI3K CARK	Homo sapiens (Human)	835	FUNCTION: May play a role in cardiac physiology. {ECO:0000303|PubMed:12721663}.	MISCELLANEOUS: [Isoform 1]: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein. {ECO:0000305}.	bundle of His cell to Purkinje myocyte communication [GO:0086069]; protein phosphorylation [GO:0006468]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; bundle of His cell to Purkinje myocyte communication [GO:0086069]; protein phosphorylation [GO:0006468]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12721663}. Cytoplasm {ECO:0000269|PubMed:12721663}. Note=Expressed at lower levels in the cytoplasm.
Q5BJD5	reviewed	TM41B_HUMAN	Transmembrane protein 41B (Protein stasimon)	TMEM41B KIAA0033	Homo sapiens (Human)	291	FUNCTION: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (PubMed:34015269, PubMed:33929485, PubMed:33850023). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (PubMed:34015269, PubMed:33929485, PubMed:33850023). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:30093494, PubMed:30126924, PubMed:30933966, PubMed:34015269, PubMed:33929485, PubMed:34043740, PubMed:33850023). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:33850023). Required for normal motor neuron development (By similarity). {ECO:0000250|UniProtKB:A1A5V7, ECO:0000269|PubMed:30093494, ECO:0000269|PubMed:30126924, ECO:0000269|PubMed:30933966, ECO:0000269|PubMed:33850023, ECO:0000269|PubMed:33929485, ECO:0000269|PubMed:34015269, ECO:0000269|PubMed:34043740}.; FUNCTION: (Microbial infection) Critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus (PubMed:33382968, PubMed:33338421). Required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles (PubMed:33382968). {ECO:0000269|PubMed:33338421, ECO:0000269|PubMed:33382968, ECO:0000269|PubMed:34043740}.		autophagosome assembly [GO:0000045]; intracellular lipid transport [GO:0032365]; modulation by host of viral RNA genome replication [GO:0044830]; nervous system development [GO:0007399]	endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]	phospholipid scramblase activity [GO:0017128]	endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; phospholipid scramblase activity [GO:0017128]; autophagosome assembly [GO:0000045]; intracellular lipid transport [GO:0032365]; modulation by host of viral RNA genome replication [GO:0044830]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30093494, ECO:0000269|PubMed:30126924, ECO:0000269|PubMed:30352685, ECO:0000269|PubMed:30933966, ECO:0000269|PubMed:33338421, ECO:0000269|PubMed:34015269, ECO:0000269|PubMed:34043740}; Multi-pass membrane protein {ECO:0000255}. Endomembrane system {ECO:0000269|PubMed:34015269}. Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. {ECO:0000269|PubMed:30352685}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:33338421}. Note=(Microbial infection) Upon infection with infection with flaviviruses, diffuse reticular-like pattern to a large cytosolic aggregate that colocalizes with viral non-structural proteins, NS4A (ZIKV) and NS4B (YFV). {ECO:0000269|PubMed:33338421}.
Q5BJF2	reviewed	SGMR2_HUMAN	Sigma intracellular receptor 2 (Sigma-2 receptor) (Sigma2 receptor) (Meningioma-associated protein 30) (Transmembrane protein 97)	TMEM97 MAC30 S2R	Homo sapiens (Human)	176	FUNCTION: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells (PubMed:28559337). Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095). Under investigation for its potential diagnostic and therapeutic uses (PubMed:23922215, PubMed:25620095). May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323). May alter the activity of some cytochrome P450 proteins (PubMed:22292588). {ECO:0000269|PubMed:19583955, ECO:0000269|PubMed:28559337, ECO:0000303|PubMed:22292588, ECO:0000303|PubMed:23922215, ECO:0000303|PubMed:25620095, ECO:0000305|PubMed:25566323}.	MISCELLANEOUS: Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile. Sigma-2 receptors are identified by radioligand-binding studies as a binding site with high affinity for di-o-tolylguanidine (DTG) and haloperidol. {ECO:0000303|PubMed:28559337}.; MISCELLANEOUS: Potentially useful for cancer diagnostics or as target for anticancer therapeutics or adjuvant anticancer treatment agents (PubMed:23922215). Some exogenous ligands display a neuroprotective effect (PubMed:25620095). {ECO:0000303|PubMed:23922215, ECO:0000303|PubMed:25620095}.	cholesterol homeostasis [GO:0042632]; regulation of cell growth [GO:0001558]	endoplasmic reticulum [GO:0005783]; lysosome [GO:0005764]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; rough endoplasmic reticulum membrane [GO:0030867]		endoplasmic reticulum [GO:0005783]; lysosome [GO:0005764]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; rough endoplasmic reticulum membrane [GO:0030867]; cholesterol homeostasis [GO:0042632]; regulation of cell growth [GO:0001558]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:19583955}; Multi-pass membrane protein {ECO:0000255}. Rough endoplasmic reticulum membrane {ECO:0000269|PubMed:19583955}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated. {ECO:0000269|PubMed:19583955}.
Q5BJF6	reviewed	ODFP2_HUMAN	Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2)	ODF2	Homo sapiens (Human)	829	FUNCTION: Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269|PubMed:16966375}.	MISCELLANEOUS: [Isoform 5]: Major. {ECO:0000305}.	cell differentiation [GO:0030154]; centriole-centriole cohesion [GO:0010457]; cilium organization [GO:0044782]; protein localization [GO:0008104]; regulation of cilium assembly [GO:1902017]; spermatogenesis [GO:0007283]	centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; spindle pole [GO:0000922]	small GTPase binding [GO:0031267]; structural molecule activity [GO:0005198]	centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; spindle pole [GO:0000922]; small GTPase binding [GO:0031267]; structural molecule activity [GO:0005198]; cell differentiation [GO:0030154]; centriole-centriole cohesion [GO:0010457]; cilium organization [GO:0044782]; protein localization [GO:0008104]; regulation of cilium assembly [GO:1902017]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:16966375}. Cell projection, cilium {ECO:0000250|UniProtKB:A3KGV1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23400999}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:A3KGV1}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A3KGV1}. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles. {ECO:0000250|UniProtKB:A3KGV1}.
Q5BJH2	reviewed	TM128_HUMAN	Transmembrane protein 128	TMEM128	Homo sapiens (Human)	165				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5BJH7	reviewed	YIF1B_HUMAN	Protein YIF1B (YIP1-interacting factor homolog B)	YIF1B PP4519 UNQ3073/PRO9905	Homo sapiens (Human)	314	FUNCTION: Functions in endoplasmic reticulum to Golgi vesicle-mediated transport and regulates the proper organization of the endoplasmic reticulum and the Golgi (By similarity). Plays a key role in targeting to neuronal dendrites receptors such as HTR1A (By similarity). Plays also a role in primary cilium and sperm flagellum assembly probably through protein transport to these compartments (PubMed:33103737). {ECO:0000250|UniProtKB:Q6PEC3, ECO:0000250|UniProtKB:Q9CX30, ECO:0000269|PubMed:33103737}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein targeting to membrane [GO:0006612]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]		COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26077767}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:26077767}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:26077767}; Multi-pass membrane protein {ECO:0000255}. Note=Shuttles between the endoplasmic reticulum, the intermediate compartment and the Golgi apparatus. {ECO:0000269|PubMed:26077767}.
Q5BKT4	reviewed	AG10A_HUMAN	Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase ALG10-A) (Alpha-2-glucosyltransferase ALG10-A) (Asparagine-linked glycosylation protein 10 homolog A)	ALG10 ALG10A	Homo sapiens (Human)	473	FUNCTION: Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity [GO:0106073]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity [GO:0106073]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Q5BKX5	reviewed	ACTMP_HUMAN	Actin maturation protease (EC 3.4.11.-) (Actin aminopeptidase ACTMAP)	ACTMAP C19orf54	Homo sapiens (Human)	351	FUNCTION: Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity). {ECO:0000250|UniProtKB:J3QPC3, ECO:0000269|PubMed:36173861}.		protein processing [GO:0016485]	cytoplasm [GO:0005737]	cysteine-type aminopeptidase activity [GO:0070005]; initiator methionyl aminopeptidase activity [GO:0004239]	cytoplasm [GO:0005737]; cysteine-type aminopeptidase activity [GO:0070005]; initiator methionyl aminopeptidase activity [GO:0004239]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:36173861}.
Q5BKX8	reviewed	CAVN4_HUMAN	Caveolae-associated protein 4 (Muscle-related coiled-coil protein) (Muscle-restricted coiled-coil protein)	CAVIN4 MURC	Homo sapiens (Human)	364	FUNCTION: Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105). {ECO:0000250|UniProtKB:A2AMM0, ECO:0000269|PubMed:18332105}.		cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018]		caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:A2AMM0}. Cytoplasm {ECO:0000250|UniProtKB:A2AMM0}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:A2AMM0}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:A2AMM0}. Membrane, caveola {ECO:0000269|PubMed:19525939}. Cell membrane {ECO:0000269|PubMed:26497963}. Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm. Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000250|UniProtKB:A2AMM0}.
Q5BKZ1	reviewed	ZN326_HUMAN	DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1)	ZNF326 ZIRD	Homo sapiens (Human)	582	FUNCTION: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. {ECO:0000269|PubMed:22446626}.		mRNA processing [GO:0006397]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	DBIRD complex [GO:0044609]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]	DBIRD complex [GO:0044609]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; mRNA processing [GO:0006397]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250}.
Q5BN46	reviewed	PIRC1_HUMAN	Piercer of microtubule wall 1 protein (Pierce1) (UPF0691 protein C9orf116) (p53-induced expression in RB-null cells protein 1)	PIERCE1	Homo sapiens (Human)	136	FUNCTION: Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Functions at the initial step of left-right asymmetry specification of the visceral organs. {ECO:0000250|UniProtKB:Q5BN45, ECO:0000269|PubMed:36191189}.		axoneme assembly [GO:0035082]; cellular response to UV-C [GO:0071494]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; DNA damage response [GO:0006974]; establishment of left/right asymmetry [GO:0061966]; regulation of gene expression [GO:0010468]	axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; nucleus [GO:0005634]		axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; axoneme assembly [GO:0035082]; cellular response to UV-C [GO:0071494]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; DNA damage response [GO:0006974]; establishment of left/right asymmetry [GO:0061966]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q5BVD1	reviewed	TTMP_HUMAN	TPA-induced transmembrane protein	TTMP C3orf52	Homo sapiens (Human)	217	FUNCTION: Has a role in LIPH-mediated synthesis of 2-acyl lysophosphatidic acid (LPA). LPA is a bioactive lipid mediator involved in different biological processes, and necessary to promote hair formation and growth. {ECO:0000269|PubMed:32336749}.			endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]		endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:32336749}; Single-pass type I membrane protein {ECO:0000305}.
Q5C9Z4	reviewed	NOM1_HUMAN	Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog)	NOM1 C7orf3	Homo sapiens (Human)	860	FUNCTION: Plays a role in targeting PPP1CA to the nucleolus. {ECO:0000269|PubMed:17965019}.		hair follicle maturation [GO:0048820]; ribosomal small subunit biogenesis [GO:0042274]	nucleolus [GO:0005730]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; RNA binding [GO:0003723]; hair follicle maturation [GO:0048820]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15715967, ECO:0000269|PubMed:17965019}.
Q5CZC0	reviewed	FSIP2_HUMAN	Fibrous sheath-interacting protein 2	FSIP2	Homo sapiens (Human)	6907	FUNCTION: Plays a role in spermatogenesis. {ECO:0000305|PubMed:30137358}.		flagellated sperm motility [GO:0030317]; protein localization to cilium [GO:0061512]; sperm axoneme assembly [GO:0007288]	sperm connecting piece [GO:0097224]; sperm end piece [GO:0097229]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]		sperm connecting piece [GO:0097224]; sperm end piece [GO:0097229]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; flagellated sperm motility [GO:0030317]; protein localization to cilium [GO:0061512]; sperm axoneme assembly [GO:0007288]	
Q5D0E6	reviewed	DALD3_HUMAN	DALR anticodon-binding domain-containing protein 3	DALRD3	Homo sapiens (Human)	543	FUNCTION: Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2A and METTL2B. {ECO:0000269|PubMed:32427860}.		arginyl-tRNA aminoacylation [GO:0006420]; tRNA C3-cytosine methylation [GO:0106217]		arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; tRNA binding [GO:0000049]	arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; tRNA binding [GO:0000049]; arginyl-tRNA aminoacylation [GO:0006420]; tRNA C3-cytosine methylation [GO:0106217]	
Q5D1E8	reviewed	ZC12A_HUMAN	Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A)	ZC3H12A MCPIP MCPIP1	Homo sapiens (Human)	599	FUNCTION: Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:26320658, PubMed:26134560, PubMed:22561375). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity). {ECO:0000250|UniProtKB:Q5D1E7, ECO:0000269|PubMed:16574901, ECO:0000269|PubMed:18364357, ECO:0000269|PubMed:19185603, ECO:0000269|PubMed:19909337, ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:22561375, ECO:0000269|PubMed:24048733, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:26134560, ECO:0000269|PubMed:26320658}.; FUNCTION: (Microbial infection) Binds to Japanese encephalitis virus (JEV) and Dengue virus (DEN) RNAs. {ECO:0000269|PubMed:23355615}.; FUNCTION: (Microbial infection) Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species. {ECO:0000269|PubMed:24191027}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to chemokine [GO:1990869]; cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-1 [GO:0071347]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; cellular response to sodium arsenite [GO:1903936]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune response-activating signaling pathway [GO:0002757]; inflammatory response [GO:0006954]; miRNA catabolic process [GO:0010587]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage activation [GO:0043031]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein complex oligomerization [GO:0051259]; protein deubiquitination [GO:0016579]; regulation of gene expression [GO:0010468]; T cell receptor signaling pathway [GO:0050852]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; rough endoplasmic reticulum membrane [GO:0030867]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA exonuclease activity [GO:0004532]; RNA nuclease activity [GO:0004540]; RNA stem-loop binding [GO:0035613]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; rough endoplasmic reticulum membrane [GO:0030867]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA exonuclease activity [GO:0004532]; RNA nuclease activity [GO:0004540]; RNA stem-loop binding [GO:0035613]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to chemokine [GO:1990869]; cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-1 [GO:0071347]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; cellular response to sodium arsenite [GO:1903936]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune response-activating signaling pathway [GO:0002757]; inflammatory response [GO:0006954]; miRNA catabolic process [GO:0010587]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage activation [GO:0043031]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein complex oligomerization [GO:0051259]; protein deubiquitination [GO:0016579]; regulation of gene expression [GO:0010468]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16574901}. Cytoplasm {ECO:0000269|PubMed:18178554, ECO:0000269|PubMed:19909337, ECO:0000269|PubMed:22055188}. Cytoplasm, P-body {ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:26134560}. Rough endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5D1E7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q5D1E7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q5D1E7}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q5D1E7}. Note=Predominantly localized in the cytoplasm. Colocalizes with GW182 on many granule-like structures, probably corresponding to cytoplasmic GW bodies (GWBs), also called processing bodies (P bodies). Colocalizes with calnexin on the surface of the rough endoplasmic reticulum (RER) membrane and with translationally active polysomes (By similarity). Colocalizes with ZC3H12D in cytoplasmic mRNA processing P-body, also known as GW bodies (GWBs) (PubMed:22055188, PubMed:26134560). {ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:26134560}.
Q5D862	reviewed	FILA2_HUMAN	Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin)	FLG2 IFPS	Homo sapiens (Human)	2391	FUNCTION: Essential for normal cell-cell adhesion in the cornified cell layers (PubMed:29758285). Important for proper integrity and mechanical strength of the stratum corneum of the epidermis (PubMed:29505760). {ECO:0000269|PubMed:29505760, ECO:0000269|PubMed:29758285}.		cell adhesion [GO:0007155]; epidermis morphogenesis [GO:0048730]; establishment of skin barrier [GO:0061436]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]	calcium ion binding [GO:0005509]; structural molecule activity [GO:0005198]; transition metal ion binding [GO:0046914]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]; calcium ion binding [GO:0005509]; structural molecule activity [GO:0005198]; transition metal ion binding [GO:0046914]; cell adhesion [GO:0007155]; epidermis morphogenesis [GO:0048730]; establishment of skin barrier [GO:0061436]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19384417}. Cytoplasmic granule {ECO:0000269|PubMed:19384417}. Note=In the stratum corneum of the epidermis, dispersed diffusely throughout the cytoplasm, while in the stratum granulosum, localized within keratohyalin granules (PubMed:19384417) (PubMed:21531719). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1. {ECO:0000269|PubMed:19384417, ECO:0000269|PubMed:21531719}.
Q5DID0	reviewed	UROL1_HUMAN	Uromodulin-like 1 (Olfactorin)	UMODL1	Homo sapiens (Human)	1318			adipose tissue development [GO:0060612]; cellular response to gonadotropin-releasing hormone [GO:0097211]; multicellular organismal reproductive process [GO:0048609]; regulation of gene expression [GO:0010468]; regulation of granulosa cell apoptotic process [GO:1904708]; regulation of ovarian follicle development [GO:2000354]; single fertilization [GO:0007338]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; peptidase inhibitor activity [GO:0030414]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; peptidase inhibitor activity [GO:0030414]; adipose tissue development [GO:0060612]; cellular response to gonadotropin-releasing hormone [GO:0097211]; multicellular organismal reproductive process [GO:0048609]; regulation of gene expression [GO:0010468]; regulation of granulosa cell apoptotic process [GO:1904708]; regulation of ovarian follicle development [GO:2000354]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15194491}; Single-pass type I membrane protein {ECO:0000269|PubMed:15194491}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
Q5DX21	reviewed	IGS11_HUMAN	Immunoglobulin superfamily member 11 (IgSF11) (Brain and testis-specific immunoglobulin superfamily protein) (Bt-IGSF) (V-set and immunoglobulin domain-containing protein 3)	IGSF11 BTIGSF CXADRL1 VSIG3	Homo sapiens (Human)	431	FUNCTION: Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth. {ECO:0000269|PubMed:15795899, ECO:0000269|PubMed:16108831}.	MISCELLANEOUS: The last 20 cytoplasmic amino acids are not required for the cell adhesion function.	cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of protein location [GO:0045185]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of mini excitatory postsynaptic potential [GO:0061885]	cell-cell junction [GO:0005911]; excitatory synapse [GO:0060076]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	ionotropic glutamate receptor binding [GO:0035255]	cell-cell junction [GO:0005911]; excitatory synapse [GO:0060076]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ionotropic glutamate receptor binding [GO:0035255]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of protein location [GO:0045185]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of mini excitatory postsynaptic potential [GO:0061885]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q5EB52	reviewed	MEST_HUMAN	Mesoderm-specific transcript homolog protein (EC 3.-.-.-) (Paternally-expressed gene 1 protein)	MEST PEG1	Homo sapiens (Human)	335			mesoderm development [GO:0007498]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]	hydrolase activity [GO:0016787]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; hydrolase activity [GO:0016787]; mesoderm development [GO:0007498]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q5EBL4	reviewed	RIPL1_HUMAN	RILP-like protein 1 (Rab-interacting lysosomal-like protein 1)	RILPL1 RLP1	Homo sapiens (Human)	403	FUNCTION: Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (PubMed:14668488). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (PubMed:30398148). {ECO:0000250|UniProtKB:D3ZUQ0, ECO:0000250|UniProtKB:Q9JJC6, ECO:0000269|PubMed:14668488, ECO:0000269|PubMed:30398148}.		cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; nitric oxide mediated signal transduction [GO:0007263]; protein transport from ciliary membrane to plasma membrane [GO:1903445]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	dynein light intermediate chain binding [GO:0051959]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; dynein light intermediate chain binding [GO:0051959]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267]; cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; nitric oxide mediated signal transduction [GO:0007263]; protein transport from ciliary membrane to plasma membrane [GO:1903445]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:14668488, ECO:0000269|PubMed:30398148}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30398148}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:30398148}.
Q5EBL8	reviewed	PDZ11_HUMAN	PDZ domain-containing protein 11 (ATPase-interacting PDZ protein) (Plasma membrane calcium ATPase-interacting single-PDZ protein) (PMCA-interacting single-PDZ protein)	PDZD11 AIPP1 PDZK11 PISP HSPC227 UNQ6486/PRO21335	Homo sapiens (Human)	140	FUNCTION: Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33. {ECO:0000269|PubMed:30463011}.		maintenance of epithelial cell apical/basal polarity [GO:0045199]; neurotransmitter secretion [GO:0007269]; pore complex assembly [GO:0046931]; protein localization to basolateral plasma membrane [GO:1903361]	adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular region [GO:0005576]; pore complex [GO:0046930]; presynapse [GO:0098793]; synapse [GO:0045202]		adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular region [GO:0005576]; pore complex [GO:0046930]; presynapse [GO:0098793]; synapse [GO:0045202]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neurotransmitter secretion [GO:0007269]; pore complex assembly [GO:0046931]; protein localization to basolateral plasma membrane [GO:1903361]	SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:12763866}. Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Cell membrane {ECO:0000269|PubMed:30463011}.
Q5EBM0	reviewed	CMPK2_HUMAN	UMP-CMP kinase 2, mitochondrial (EC 2.7.4.14) (Nucleoside-diphosphate kinase) (EC 2.7.4.6)	CMPK2	Homo sapiens (Human)	449	FUNCTION: Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways (PubMed:17999954, PubMed:30083606, PubMed:36930652, PubMed:37075076). Restricts the replication of multiple viruses including flaviviruses or coronaviruses (PubMed:30083606, PubMed:36930652, PubMed:37075076). Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities (PubMed:36930652). Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity (PubMed:37075076). Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonucleotides (By similarity). CMPK2-dependent mitochondrial DNA synthesis is necessary for the production of oxidized mitochondrial DNA fragments after exposure to NLRP3 activators (By similarity). In turn, cytosolic oxidized mtDNA associates with the NLRP3 inflammasome complex and is required for its activation (By similarity). {ECO:0000250|UniProtKB:Q3U5Q7, ECO:0000269|PubMed:17999954, ECO:0000269|PubMed:23416111, ECO:0000269|PubMed:30083606, ECO:0000269|PubMed:34142025, ECO:0000269|PubMed:36930652, ECO:0000269|PubMed:37075076}.		cellular response to lipopolysaccharide [GO:0071222]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; cytidylate kinase activity [GO:0004127]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]; thymidylate kinase activity [GO:0004798]; UMP kinase activity [GO:0033862]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; cytidylate kinase activity [GO:0004127]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]; thymidylate kinase activity [GO:0004798]; UMP kinase activity [GO:0033862]; cellular response to lipopolysaccharide [GO:0071222]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:17999954, ECO:0000269|PubMed:34142025, ECO:0000269|PubMed:37075076}. Note=Mitochondrial localization is required for its antiviral function. {ECO:0000269|PubMed:37075076}.
Q5EE01	reviewed	CENPW_HUMAN	Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein)	CENPW C6orf173 CUG2	Homo sapiens (Human)	88	FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000250, ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:19533040, ECO:0000269|PubMed:21695110, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22304917}.		cell division [GO:0051301]; CENP-A containing chromatin assembly [GO:0034080]; chromosome organization [GO:0051276]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278]	chromosome, centromeric region [GO:0000775]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]	chromosome, centromeric region [GO:0000775]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; cell division [GO:0051301]; CENP-A containing chromatin assembly [GO:0034080]; chromosome organization [GO:0051276]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17610844}. Chromosome, centromere {ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:19533040, ECO:0000269|PubMed:22304917}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:22304917}. Nucleus matrix {ECO:0000269|PubMed:22002061}. Nucleus, nucleolus {ECO:0000269|PubMed:22002061}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis. {ECO:0000250|UniProtKB:P0DJH6}.
Q5EG05	reviewed	CAR16_HUMAN	Caspase recruitment domain-containing protein 16 (Caspase recruitment domain-only protein 1) (CARD-only protein 1) (Caspase-1 inhibitor COP) (Pseudo interleukin-1 beta converting enzyme) (Pseudo-ICE) (Pseudo-IL1B-converting enzyme)	CARD16 COP COP1	Homo sapiens (Human)	197	FUNCTION: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016, ECO:0000269|PubMed:16920334}.		cellular response to lipopolysaccharide [GO:0071222]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of protein binding [GO:0032091]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteolysis [GO:0006508]; regulation of inflammatory response [GO:0050727]	AIM2 inflammasome complex [GO:0097169]; IPAF inflammasome complex [GO:0072557]; NLRP3 inflammasome complex [GO:0072559]; protease inhibitor complex [GO:0097179]; protein-containing complex [GO:0032991]	CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]	AIM2 inflammasome complex [GO:0097169]; IPAF inflammasome complex [GO:0072557]; NLRP3 inflammasome complex [GO:0072559]; protease inhibitor complex [GO:0097179]; protein-containing complex [GO:0032991]; CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; cellular response to lipopolysaccharide [GO:0071222]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of protein binding [GO:0032091]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteolysis [GO:0006508]; regulation of inflammatory response [GO:0050727]	
Q5F1R6	reviewed	DJC21_HUMAN	DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3)	DNAJC21 DNAJA5	Homo sapiens (Human)	531	FUNCTION: May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}.		protein folding [GO:0006457]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; ribosome [GO:0005840]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; ribosome [GO:0005840]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27346687}. Nucleus {ECO:0000269|PubMed:27346687}. Nucleus, nucleolus {ECO:0000269|PubMed:27346687}. Note=Within the nucleus, localizes primarily to the nucleolus. {ECO:0000269|PubMed:27346687}.
Q5FBB7	reviewed	SGO1_HUMAN	Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1)	SGO1 SGOL1	Homo sapiens (Human)	561	FUNCTION: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:15737064, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:20739936}.	MISCELLANEOUS: Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin).	attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; centriole-centriole cohesion [GO:0010457]; chromosome segregation [GO:0007059]; meiotic chromosome segregation [GO:0045132]; mitotic sister chromatid cohesion, centromeric [GO:0071962]	centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]	kinase binding [GO:0019900]	centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]; kinase binding [GO:0019900]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; centriole-centriole cohesion [GO:0010457]; chromosome segregation [GO:0007059]; meiotic chromosome segregation [GO:0045132]; mitotic sister chromatid cohesion, centromeric [GO:0071962]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:16582621}. Chromosome, centromere {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:21346195}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16582621, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16582621, ECO:0000269|PubMed:18331714}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18331714}. Note=Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase (PubMed:16541025). Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A (PubMed:16580887)(PubMed:16541025)(PubMed:15604152). Colocalizes with NEK2 at the kinetochore (PubMed:17621308). Colocalizes with and SS18L1 at the kinetochore (PubMed:16582621). Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore (PubMed:17617734). Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis (PubMed:16582621). Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent (PubMed:16582621). Isoform 3 does not localize to kinetochores during any stages of the cell cycle (PubMed:16582621). {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:16582621, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308}.
Q5FVE4	reviewed	ACBG2_HUMAN	Long-chain-fatty-acid--CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 2) (Arachidonate--CoA ligase ACSBG2) (EC 6.2.1.15) (Bubblegum-related protein) (PRTD-NY3)	ACSBG2 BGR UNQ2443/PRO5005	Homo sapiens (Human)	666	FUNCTION: Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:16371355, PubMed:16762313). Has increased ability to activate oleic and linoleic acid (PubMed:16371355). May play a role in spermatogenesis (PubMed:15685348). {ECO:0000269|PubMed:15685348, ECO:0000269|PubMed:16371355, ECO:0000269|PubMed:16762313}.		cell differentiation [GO:0030154]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]	acyl-CoA hydrolase activity [GO:0047617]; arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; acyl-CoA hydrolase activity [GO:0047617]; arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; cell differentiation [GO:0030154]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein.
Q5FWF4	reviewed	ZRAB3_HUMAN	DNA annealing helicase and endonuclease ZRANB3 (Annealing helicase 2) (AH2) (Zinc finger Ran-binding domain-containing protein 3) [Includes: DNA annealing helicase ZRANB3 (EC 3.6.4.-); Endonuclease ZRANB3 (EC 3.1.-.-)]	ZRANB3	Homo sapiens (Human)	1079	FUNCTION: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558). {ECO:0000269|PubMed:21078962, ECO:0000269|PubMed:22704558, ECO:0000269|PubMed:22705370, ECO:0000269|PubMed:22759634, ECO:0000269|PubMed:26884333}.	MISCELLANEOUS: In contrast to classical helicases that unwing DNA, annealing helicases rewind it. {ECO:0000305|PubMed:21078962}.	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA rewinding [GO:0036292]; negative regulation of DNA recombination [GO:0045910]; replication fork processing [GO:0031297]; replication fork reversal [GO:0071932]; response to UV [GO:0009411]	nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; DNA endonuclease activity [GO:0004520]; helicase activity [GO:0004386]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270]	nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; DNA endonuclease activity [GO:0004520]; helicase activity [GO:0004386]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA rewinding [GO:0036292]; negative regulation of DNA recombination [GO:0045910]; replication fork processing [GO:0031297]; replication fork reversal [GO:0071932]; response to UV [GO:0009411]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22704558, ECO:0000269|PubMed:22705370, ECO:0000269|PubMed:22759634}. Chromosome {ECO:0000269|PubMed:22704558, ECO:0000269|PubMed:22705370, ECO:0000269|PubMed:22759634}. Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA (PubMed:22704558, PubMed:22705370, PubMed:22759634). {ECO:0000269|PubMed:22704558, ECO:0000269|PubMed:22705370, ECO:0000269|PubMed:22759634}.
Q5FWF5	reviewed	ESCO1_HUMAN	N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1)	ESCO1 EFO1 KIAA1911	Homo sapiens (Human)	840	FUNCTION: Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). {ECO:0000269|PubMed:14576321, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:18614053, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mitotic sister chromatid cohesion [GO:0007064]; peptidyl-lysine acetylation [GO:0018394]; post-translational protein acetylation [GO:0034421]; regulation of DNA replication [GO:0006275]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	acetyltransferase activity [GO:0016407]; identical protein binding [GO:0042802]; N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; acetyltransferase activity [GO:0016407]; identical protein binding [GO:0042802]; N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; zinc ion binding [GO:0008270]; mitotic sister chromatid cohesion [GO:0007064]; peptidyl-lysine acetylation [GO:0018394]; post-translational protein acetylation [GO:0034421]; regulation of DNA replication [GO:0006275]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14576321, ECO:0000269|PubMed:15958495}. Chromosome {ECO:0000269|PubMed:15958495}. Note=Nuclear at interphase, associated with chromosomes during mitosis. {ECO:0000269|PubMed:15958495}.
Q5FYB1	reviewed	ARSI_HUMAN	Arylsulfatase I (ASI) (EC 3.1.6.-)	ARSI	Homo sapiens (Human)	569	FUNCTION: Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts (PubMed:19262745). Lacks arylsulfatase activity (PubMed:16500042). {ECO:0000269|PubMed:16500042, ECO:0000269|PubMed:19262745}.			endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]	arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19262745}. Endoplasmic reticulum {ECO:0000269|PubMed:19262745}. Note=Localized in the intracellular granular structures.
Q5GFL6	reviewed	VWA2_HUMAN	von Willebrand factor A domain-containing protein 2 (A domain-containing protein similar to matrilin and collagen) (AMACO) (Colon cancer secreted protein 2) (CCSP-2)	VWA2 AMACO	Homo sapiens (Human)	755		MISCELLANEOUS: May be used as a serological marker for colon neoplasia.	calcium-independent cell-matrix adhesion [GO:0007161]; regulation of insulin receptor signaling pathway [GO:0046626]	basement membrane [GO:0005604]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]	basement membrane [GO:0005604]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; calcium-independent cell-matrix adhesion [GO:0007161]; regulation of insulin receptor signaling pathway [GO:0046626]	SUBCELLULAR LOCATION: Secreted.
Q5GLZ8	reviewed	HERC4_HUMAN	Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4)	HERC4 KIAA1593	Homo sapiens (Human)	1057	FUNCTION: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. {ECO:0000250|UniProtKB:Q6PAV2}.		cell differentiation [GO:0030154]; negative regulation of smoothened signaling pathway [GO:0045879]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; ubiquitin protein ligase activity [GO:0061630]; cell differentiation [GO:0030154]; negative regulation of smoothened signaling pathway [GO:0045879]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15676274}. Note=shows a punctate cytoplasmic distribution.
Q5H8A4	reviewed	PIGG_HUMAN	GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G)	PIGG GPI7 UNQ1930/PRO4405	Homo sapiens (Human)	983	FUNCTION: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. {ECO:0000269|PubMed:15632136, ECO:0000269|PubMed:34113002}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	CP2 mannose-ethanolamine phosphotransferase activity [GO:0051267]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; transferase activity [GO:0016740]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; CP2 mannose-ethanolamine phosphotransferase activity [GO:0051267]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; transferase activity [GO:0016740]; GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15632136}; Multi-pass membrane protein {ECO:0000269|PubMed:15632136}.
Q5H8C1	reviewed	FREM1_HUMAN	FRAS1-related extracellular matrix protein 1 (Protein QBRICK)	FREM1 C9orf143 C9orf145 C9orf154	Homo sapiens (Human)	2179	FUNCTION: Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development. {ECO:0000250}.	MISCELLANEOUS: Was termed QBRICK because it contains 12 repeats: 'Q' stands for queen and is taken from the queen being the 12th in a suit of playing card, and 'BRICK' stands for the repeating unit.	anatomical structure morphogenesis [GO:0009653]; cell communication [GO:0007154]; cell-matrix adhesion [GO:0007160]; craniofacial suture morphogenesis [GO:0097094]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; membrane [GO:0016020]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; membrane [GO:0016020]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; anatomical structure morphogenesis [GO:0009653]; cell communication [GO:0007154]; cell-matrix adhesion [GO:0007160]; craniofacial suture morphogenesis [GO:0097094]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:Q684R7}. Note=Localizes at the basement membrane zone of embryonic epidermis and hair follicles. {ECO:0000250|UniProtKB:Q684R7}.
Q5H9F3	reviewed	BCORL_HUMAN	BCL-6 corepressor-like protein 1 (BCoR-L1) (BCoR-like protein 1)	BCORL1	Homo sapiens (Human)	1785	FUNCTION: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. {ECO:0000269|PubMed:17379597}.		chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription corepressor activity [GO:0003714]; chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17379597}.
Q5H9I0	reviewed	TFDP3_HUMAN	Transcription factor Dp family member 3 (Cancer/testis antigen 30) (CT30) (Hepatocellular carcinoma-associated antigen 661)	TFDP3 DP4 HCA661	Homo sapiens (Human)	405	FUNCTION: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase. {ECO:0000269|PubMed:16418725, ECO:0000269|PubMed:17062573, ECO:0000269|PubMed:20559320}.		DNA damage response [GO:0006974]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator inhibitor activity [GO:0140416]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator inhibitor activity [GO:0140416]; DNA damage response [GO:0006974]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members.
Q5H9J7	reviewed	BEX5_HUMAN	Protein BEX5 (Brain-expressed X-linked protein 5) (NGFRAP1-like protein 1) (Nerve growth factor receptor-associated protein 2)	BEX5 NADE2 NGFRAP1L1	Homo sapiens (Human)	111		MISCELLANEOUS: The mouse orthologous protein seems not to exist. A publication described a sequence that they named Bex5, but it probably represents a pseudogene (PubMed:15861462). {ECO:0000305|PubMed:15861462}.	signal transduction [GO:0007165]	cytoplasm [GO:0005737]	signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; signaling receptor binding [GO:0005102]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15958283}.
Q5H9L4	reviewed	TAF7L_HUMAN	Transcription initiation factor TFIID subunit 7-like (Cancer/testis antigen 40) (CT40) (RNA polymerase II TBP-associated factor subunit Q) (TATA box-binding protein-associated factor 50 kDa) (Transcription initiation factor TFIID 50 kDa subunit)	TAF7L TAF2Q	Homo sapiens (Human)	462	FUNCTION: Probably functions as a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; transcription factor TFIID complex [GO:0005669]		cytoplasm [GO:0005737]; transcription factor TFIID complex [GO:0005669]; cell differentiation [GO:0030154]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Cytoplasmic in spermatogonia and early spermatocytes (preleptotene, leptotene, and zygotene); translocates into the nuclei of pachytene spermatocytes and round spermatids. {ECO:0000250}.
Q5H9R7	reviewed	PP6R3_HUMAN	Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL)	PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3	Homo sapiens (Human)	873	FUNCTION: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}.		regulation of phosphoprotein phosphatase activity [GO:0043666]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]; regulation of phosphoprotein phosphatase activity [GO:0043666]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q5H9S7	reviewed	DCA17_HUMAN	DDB1- and CUL4-associated factor 17	DCAF17 C2orf37	Homo sapiens (Human)	520	FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}.		protein ubiquitination [GO:0016567]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Nucleus, nucleolus {ECO:0000269|PubMed:19026396}. Note=According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions.
Q5HYA8	reviewed	MKS3_HUMAN	Meckelin (Meckel syndrome type 3 protein) (Transmembrane protein 67)	TMEM67 MKS3	Homo sapiens (Human)	995	FUNCTION: Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Is a key regulator of stereociliary bundle orientation (By similarity). Required for epithelial cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A (PubMed:26035863). In non-canonical Wnt signaling, it may act as ROR2 coreceptor (By similarity). {ECO:0000250|UniProtKB:Q8BR76, ECO:0000269|PubMed:17185389, ECO:0000269|PubMed:19515853, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:19815549, ECO:0000269|PubMed:26035863}.		cilium assembly [GO:0060271]; negative regulation of centrosome duplication [GO:0010826]; non-canonical Wnt signaling pathway [GO:0035567]; ubiquitin-dependent ERAD pathway [GO:0030433]	centrosome [GO:0005813]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; MKS complex [GO:0036038]	filamin binding [GO:0031005]; unfolded protein binding [GO:0051082]	centrosome [GO:0005813]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; MKS complex [GO:0036038]; filamin binding [GO:0031005]; unfolded protein binding [GO:0051082]; cilium assembly [GO:0060271]; negative regulation of centrosome duplication [GO:0010826]; non-canonical Wnt signaling pathway [GO:0035567]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17185389}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19815549}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium {ECO:0000269|PubMed:17185389}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22121117}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:22121117). {ECO:0000269|PubMed:22121117}.
Q5HYI8	reviewed	RABL3_HUMAN	Rab-like protein 3	RABL3	Homo sapiens (Human)	236	FUNCTION: Required for KRAS signaling regulation and modulation of cell proliferation (PubMed:31406347). Regulator of KRAS prenylation, and probably prenylation of other small GTPases (PubMed:31406347). Required for lymphocyte development and function (By similarity). Not required for myeloid cell development (By similarity). {ECO:0000250|UniProtKB:Q9D4V7, ECO:0000269|PubMed:31406347}.		B cell differentiation [GO:0030183]; intracellular protein transport [GO:0006886]; natural killer cell differentiation [GO:0001779]; protein stabilization [GO:0050821]; regulation of protein lipidation [GO:1903059]; regulation of Ras protein signal transduction [GO:0046578]; T cell differentiation in thymus [GO:0033077]	endomembrane system [GO:0012505]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein homodimerization activity [GO:0042803]	endomembrane system [GO:0012505]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein homodimerization activity [GO:0042803]; B cell differentiation [GO:0030183]; intracellular protein transport [GO:0006886]; natural killer cell differentiation [GO:0001779]; protein stabilization [GO:0050821]; regulation of protein lipidation [GO:1903059]; regulation of Ras protein signal transduction [GO:0046578]; T cell differentiation in thymus [GO:0033077]	
Q5HYJ3	reviewed	FA76B_HUMAN	Protein FAM76B	FAM76B	Homo sapiens (Human)	339				nuclear speck [GO:0016607]		nuclear speck [GO:0016607]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:19266028}.
Q5HYK3	reviewed	COQ5_HUMAN	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (EC 2.1.1.201) (Ubiquinone biosynthesis methyltransferase COQ5)	COQ5	Homo sapiens (Human)	327	FUNCTION: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). {ECO:0000255|HAMAP-Rule:MF_03191}.		methylation [GO:0032259]; ubiquinone biosynthetic process [GO:0006744]	extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; protein-containing complex [GO:0032991]; ubiquinone biosynthesis complex [GO:0110142]	2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [GO:0043430]; 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity [GO:0043333]; methyltransferase activity [GO:0008168]	extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; protein-containing complex [GO:0032991]; ubiquinone biosynthesis complex [GO:0110142]; 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [GO:0043430]; 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity [GO:0043333]; methyltransferase activity [GO:0008168]; methylation [GO:0032259]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03191, ECO:0000269|PubMed:25152161, ECO:0000269|PubMed:35614220}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03191, ECO:0000269|PubMed:25152161}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03191, ECO:0000269|PubMed:25152161}.
Q5HYK7	reviewed	SH319_HUMAN	SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP)	SH3D19	Homo sapiens (Human)	790	FUNCTION: May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:14551139, ECO:0000269|PubMed:15280379, ECO:0000269|PubMed:21834987}.		cytoskeleton organization [GO:0007010]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; regulation of cell morphogenesis [GO:0022604]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	proline-rich region binding [GO:0070064]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proline-rich region binding [GO:0070064]; cytoskeleton organization [GO:0007010]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; regulation of cell morphogenesis [GO:0022604]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14551139}. Nucleus {ECO:0000269|PubMed:14551139}. Note=Is recruited to the nucleus by the KMT2A/MLL1-EEN fusion protein.
Q5HYN5	reviewed	CT451_HUMAN	Cancer/testis antigen family 45 member A1 (Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1)	CT45A1 CT45-1	Homo sapiens (Human)	189							
Q5HYW2	reviewed	NHSL2_HUMAN	NHS-like protein 2	NHSL2	Homo sapiens (Human)	1225			cell differentiation [GO:0030154]			cell differentiation [GO:0030154]	
Q5I7T1	reviewed	AG10B_HUMAN	Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase ALG10-A) (Alpha-2-glucosyltransferase ALG10-B) (Asparagine-linked glycosylation protein 10 homolog B) (Potassium channel regulator 1)	ALG10B KCR1	Homo sapiens (Human)	473	FUNCTION: Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (PubMed:14525949). Has a role in maintenance of cochlear outer hair cell function (By similarity). {ECO:0000250|UniProtKB:P50076, ECO:0000250|UniProtKB:Q3UGP8, ECO:0000269|PubMed:14525949}.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; positive regulation of inward rectifier potassium channel activity [GO:1901980]; positive regulation of protein glycosylation [GO:0060050]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity [GO:0106073]; transferase activity [GO:0016740]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity [GO:0106073]; transferase activity [GO:0016740]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; positive regulation of inward rectifier potassium channel activity [GO:1901980]; positive regulation of protein glycosylation [GO:0060050]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O88788}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O88788}.
Q5IJ48	reviewed	CRUM2_HUMAN	Protein crumbs homolog 2 (Crumbs-like protein 2)	CRB2	Homo sapiens (Human)	1285	FUNCTION: Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo (By similarity). Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer (By similarity). The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB (By similarity). Plays a role in the maintenance of retinal neuroepithelium organization, structural integrity, adhesion, photoreceptor polarity and retinal photoreceptor layer thickness (By similarity). May play a role in determining the length of cone photoreceptor outer segments and proliferation of late-born progenitor cells (By similarity). Also required for maintenance of the apical polarity complex during development of the cortex (By similarity). Inhibits gamma-secretase-dependent cleavage of APP and secretion of amyloid-beta peptide 40 and amyloid-beta peptide 42, and thereby inhibits gamma-secretase-dependent Notch transcription (PubMed:20299451). {ECO:0000250|UniProtKB:Q80YA8, ECO:0000269|PubMed:20299451}.		circulatory system development [GO:0072359]; establishment of cell polarity [GO:0030010]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; ingression involved in gastrulation with mouth forming second [GO:0055111]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesoderm formation [GO:0001707]; negative regulation of endopeptidase activity [GO:0010951]; notochord formation [GO:0014028]; photoreceptor cell maintenance [GO:0045494]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; regulation of gastrulation [GO:0010470]; response to stimulus [GO:0050896]; retina homeostasis [GO:0001895]; retinal cone cell development [GO:0046549]; somitogenesis [GO:0001756]; visual perception [GO:0007601]	apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; subapical complex [GO:0035003]	aspartic-type endopeptidase inhibitor activity [GO:0019828]; calcium ion binding [GO:0005509]; protein-containing complex binding [GO:0044877]	apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; subapical complex [GO:0035003]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; calcium ion binding [GO:0005509]; protein-containing complex binding [GO:0044877]; circulatory system development [GO:0072359]; establishment of cell polarity [GO:0030010]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; ingression involved in gastrulation with mouth forming second [GO:0055111]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesoderm formation [GO:0001707]; negative regulation of endopeptidase activity [GO:0010951]; notochord formation [GO:0014028]; photoreceptor cell maintenance [GO:0045494]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; regulation of gastrulation [GO:0010470]; response to stimulus [GO:0050896]; retina homeostasis [GO:0001895]; retinal cone cell development [GO:0046549]; somitogenesis [GO:0001756]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: [Isoform 1]: Apical cell membrane {ECO:0000250|UniProtKB:Q80YA8}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q80YA8}. Cell junction {ECO:0000250|UniProtKB:Q80YA8}. Note=O-glucosylation is required for localization at the apical plasma membrane (By similarity). Distributed in a complex anisotropic pattern on apical cell edges: the level of CRB2 on a cell edge is inversely correlated with the level of MYH10/myosin-IIB (By similarity). {ECO:0000250|UniProtKB:Q80YA8}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000255}.
Q5J8M3	reviewed	EMC4_HUMAN	ER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85)	EMC4 TMEM85 HSPC184 PIG17	Homo sapiens (Human)	183	FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305|PubMed:18586032}.		apoptotic process [GO:0006915]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]		EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; apoptotic process [GO:0006915]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Multi-pass membrane protein {ECO:0000305|PubMed:32439656, ECO:0000305|PubMed:32459176}. Note=Could also be a single-pass transmembrane protein with cytosolic N-terminus and lumenal C-terminus. {ECO:0000305|PubMed:32439656, ECO:0000305|PubMed:32459176}.
Q5J8X5	reviewed	M4A13_HUMAN	Membrane-spanning 4-domains subfamily A member 13 (Testis-expressed transmembrane protein 4)	MS4A13	Homo sapiens (Human)	152	FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex. {ECO:0000250}.		cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5JPE7	reviewed	NOMO2_HUMAN	BOS complex subunit NOMO2 (Nodal modulator 2) (pM5 protein 2)	NOMO2	Homo sapiens (Human)	1267	FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261522, PubMed:32820719). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). {ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.		multi-pass transmembrane protein insertion into ER membrane [GO:0160063]	endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]; protein-containing complex [GO:0032991]	carbohydrate binding [GO:0030246]; ribosome binding [GO:0043022]	endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]; protein-containing complex [GO:0032991]; carbohydrate binding [GO:0030246]; ribosome binding [GO:0043022]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15257293, ECO:0000269|PubMed:17261586, ECO:0000269|PubMed:36261522}; Single-pass type I membrane protein {ECO:0000255}.
Q5JPH6	reviewed	SYEM_HUMAN	Probable glutamate--tRNA ligase, mitochondrial (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS)	EARS2 KIAA1970	Homo sapiens (Human)	523	FUNCTION: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). {ECO:0000250}.		glutamyl-tRNA aminoacylation [GO:0006424]; tRNA aminoacylation for mitochondrial protein translation [GO:0070127]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; glutamate-tRNA(Gln) ligase activity [GO:0050561]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; glutamate-tRNA(Gln) ligase activity [GO:0050561]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; glutamyl-tRNA aminoacylation [GO:0006424]; tRNA aminoacylation for mitochondrial protein translation [GO:0070127]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
Q5JPI9	reviewed	EFMT2_HUMAN	EEF1A lysine methyltransferase 2 (EC 2.1.1.-) (Methyltransferase-like protein 10) (Protein-lysine N-methyltransferase METTL10)	EEF1AKMT2 C10orf138 METTL10	Homo sapiens (Human)	291	FUNCTION: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. {ECO:0000255|HAMAP-Rule:MF_03188, ECO:0000269|PubMed:25144183}.		peptidyl-lysine methylation [GO:0018022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone methyltransferase activity [GO:0042054]; methyltransferase activity [GO:0008168]; protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone methyltransferase activity [GO:0042054]; methyltransferase activity [GO:0008168]; protein-lysine N-methyltransferase activity [GO:0016279]; peptidyl-lysine methylation [GO:0018022]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03188, ECO:0000269|PubMed:25144183}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03188, ECO:0000269|PubMed:25144183}.
Q5JQC9	reviewed	AKAP4_HUMAN	A-kinase anchor protein 4 (AKAP-4) (A-kinase anchor protein 82 kDa) (AKAP 82) (hAKAP82) (Major sperm fibrous sheath protein) (HI) (Protein kinase A-anchoring protein 4) (PRKA4)	AKAP4 AKAP82	Homo sapiens (Human)	854	FUNCTION: Major structural component of sperm fibrous sheath. Plays a role in sperm motility. {ECO:0000269|PubMed:9822690}.		establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; flagellated sperm motility [GO:0030317]; protein localization [GO:0008104]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; sperm flagellum assembly [GO:0120316]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]	cAMP-dependent protein kinase complex [GO:0005952]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sperm connecting piece [GO:0097224]; sperm end piece [GO:0097229]; sperm fibrous sheath [GO:0035686]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; Z disc [GO:0030018]	protein kinase A binding [GO:0051018]	cAMP-dependent protein kinase complex [GO:0005952]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sperm connecting piece [GO:0097224]; sperm end piece [GO:0097229]; sperm fibrous sheath [GO:0035686]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; Z disc [GO:0030018]; protein kinase A binding [GO:0051018]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; flagellated sperm motility [GO:0030317]; protein localization [GO:0008104]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; sperm flagellum assembly [GO:0120316]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:9822690}. Note=Localizes to the principle piece of the sperm flagellum.
Q5JR59	reviewed	MTUS2_HUMAN	Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa)	MTUS2 CAZIP KIAA0774 TIP150	Homo sapiens (Human)	1369	FUNCTION: Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. {ECO:0000269|PubMed:19543227}.			cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]	microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19543227}. Note=Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules.
Q5JR98	reviewed	DYLT4_HUMAN	Dynein light chain Tctex-type 4 (Protein N22.1) (Tctex-2-beta) (Tctex1 domain-containing protein 4)	DYNLT4 TCTEX1D4	Homo sapiens (Human)	221			microtubule-based movement [GO:0007018]	acrosomal vesicle [GO:0001669]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; intracellular membrane-bounded organelle [GO:0043231]; microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	dynein intermediate chain binding [GO:0045505]; protein phosphatase 1 binding [GO:0008157]	acrosomal vesicle [GO:0001669]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; intracellular membrane-bounded organelle [GO:0043231]; microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; dynein intermediate chain binding [GO:0045505]; protein phosphatase 1 binding [GO:0008157]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:23789093}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:23789093}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23789093}. Cytoplasm {ECO:0000250|UniProtKB:Q8CDY7}. Nucleus {ECO:0000250|UniProtKB:Q8CDY7}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:23789093}. Note=Present along the entire length of the flagellum, including principal and endpiece, and more predominantly in the midpiece region. {ECO:0000269|PubMed:23789093}.
Q5JRA6	reviewed	TGO1_HUMAN	Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3)	MIA3 KIAA0268 TANGO UNQ6077/PRO20088	Homo sapiens (Human)	1907	FUNCTION: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}.		cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; lipoprotein transport [GO:0042953]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell migration [GO:0030336]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of lymphocyte migration [GO:2000402]; positive regulation of leukocyte migration [GO:0002687]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein secretion [GO:0009306]; protein transport [GO:0015031]; vesicle cargo loading [GO:0035459]; wound healing [GO:0042060]	endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	cargo receptor activity [GO:0038024]	endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; cargo receptor activity [GO:0038024]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; lipoprotein transport [GO:0042953]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell migration [GO:0030336]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of lymphocyte migration [GO:2000402]; positive regulation of leukocyte migration [GO:0002687]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein secretion [GO:0009306]; protein transport [GO:0015031]; vesicle cargo loading [GO:0035459]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:32101163}; Single-pass membrane protein {ECO:0000269|PubMed:19269366}. Note=Localizes at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:32101163). SEC16A is required for its proper localization to ERES. After loading of COL7A1 into transport carriers, it is not incorporated into COPII carriers and remains in the endoplasmic reticulum membrane. {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:28442536}.
Q5JRX3	reviewed	PREP_HUMAN	Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)	PITRM1 KIAA1104 MP1 PREP	Homo sapiens (Human)	1037	FUNCTION: Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469). Has an ATP-independent activity (PubMed:16849325). Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155). Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469). Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155). Also degrades other unstructured peptides (PubMed:19196155). It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469, PubMed:26697887). It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469, PubMed:29764912, PubMed:29383861). Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469). It is also able to degrade amyloid-beta protein 42 (PubMed:29764912). {ECO:0000269|PubMed:10360838, ECO:0000269|PubMed:16849325, ECO:0000269|PubMed:19196155, ECO:0000269|PubMed:24931469, ECO:0000269|PubMed:26697887, ECO:0000269|PubMed:29383861, ECO:0000269|PubMed:29764912}.		protein processing [GO:0016485]; protein targeting to mitochondrion [GO:0006626]; proteolysis [GO:0006508]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	enzyme activator activity [GO:0008047]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; enzyme activator activity [GO:0008047]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; protein processing [GO:0016485]; protein targeting to mitochondrion [GO:0006626]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:26697887}. Mitochondrion matrix {ECO:0000269|PubMed:16849325, ECO:0000269|PubMed:19196155, ECO:0000269|PubMed:21621546}.
Q5JS13	reviewed	RGPS1_HUMAN	Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (Ral guanine nucleotide exchange factor 2) (RalGEF 2) (RalA exchange factor RalGPS1)	RALGPS1 KIAA0351 RALGEF2	Homo sapiens (Human)	557	FUNCTION: Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for. {ECO:0000250, ECO:0000269|PubMed:10747847, ECO:0000269|PubMed:10889189}.		intracellular signal transduction [GO:0035556]; Ras protein signal transduction [GO:0007265]; regulation of Ral protein signal transduction [GO:0032485]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; intracellular signal transduction [GO:0035556]; Ras protein signal transduction [GO:0007265]; regulation of Ral protein signal transduction [GO:0032485]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10889189}. Cell membrane {ECO:0000269|PubMed:10889189}. Note=Associates with membranes through the PH domain.
Q5JSH3	reviewed	WDR44_HUMAN	WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11)	WDR44 RPH11	Homo sapiens (Human)	913	FUNCTION: Downstream effector for Rab11 involved in the inhibition of the intracellular ciliogenesis pathway in concert with AKT1 kinase (PubMed:31204173). When the LPAR1 receptor signaling pathway is activated, phosphorylated WDR44 binds to Rab11, thus preventing the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex (PubMed:31204173). Together with Rab11, also participates in the regulation of vesicle recycling (By similarity). {ECO:0000250|UniProtKB:Q9R037, ECO:0000269|PubMed:31204173}.		cytosolic ciliogenesis [GO:0061824]; negative regulation of cilium assembly [GO:1902018]; regulation of vesicle-mediated transport [GO:0060627]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]	molecular sequestering activity [GO:0140313]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; molecular sequestering activity [GO:0140313]; small GTPase binding [GO:0031267]; cytosolic ciliogenesis [GO:0061824]; negative regulation of cilium assembly [GO:1902018]; regulation of vesicle-mediated transport [GO:0060627]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9R037}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9R037}. Endosome membrane {ECO:0000250|UniProtKB:Q9R037}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9R037}. Note=Colocalized with RAB11A along microtubules oriented toward lamellipodia. {ECO:0000250|UniProtKB:Q9R037}.
Q5JSL3	reviewed	DOC11_HUMAN	Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2)	DOCK11 ZIZ2	Homo sapiens (Human)	2073	FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42. {ECO:0000250|UniProtKB:A2AF47}.	MISCELLANEOUS: 'Zizim' means 'spike' in Hebrew. {ECO:0000305}.	B cell homeostasis [GO:0001782]; marginal zone B cell differentiation [GO:0002315]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; B cell homeostasis [GO:0001782]; marginal zone B cell differentiation [GO:0002315]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; small GTPase mediated signal transduction [GO:0007264]	
Q5JSP0	reviewed	FGD3_HUMAN	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5)	FGD3 ZFYVE5	Homo sapiens (Human)	725	FUNCTION: Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.		actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726]	guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}.
Q5JST6	reviewed	EFHC2_HUMAN	EF-hand domain-containing family member C2	EFHC2	Homo sapiens (Human)	749	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.		cellular response to leukemia inhibitory factor [GO:1990830]; regulation of neuron projection development [GO:0010975]	axonemal microtubule [GO:0005879]; ciliary basal body [GO:0036064]	calcium ion binding [GO:0005509]	axonemal microtubule [GO:0005879]; ciliary basal body [GO:0036064]; calcium ion binding [GO:0005509]; cellular response to leukemia inhibitory factor [GO:1990830]; regulation of neuron projection development [GO:0010975]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q5JT25	reviewed	RAB41_HUMAN	Ras-related protein Rab-41	RAB41	Homo sapiens (Human)	222	FUNCTION: Required for normal Golgi ribbon organization and ER-to-Golgi trafficking. {ECO:0000269|PubMed:23936529}.		intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23936529}. Note=punctate localization concentrated in ruffled regions at the cell periphery.
Q5JTC6	reviewed	AMER1_HUMAN	APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein)	AMER1 FAM123B WTX	Homo sapiens (Human)	1135	FUNCTION: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}.	MISCELLANEOUS: Inactivated in approximately one-third of Wilms tumors.	adipose tissue development [GO:0060612]; bone development [GO:0060348]; mesenchymal cell differentiation involved in kidney development [GO:0072161]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein ubiquitination [GO:0031398]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]	beta-catenin binding [GO:0008013]; beta-catenin destruction complex binding [GO:1904713]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; beta-catenin destruction complex binding [GO:1904713]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; adipose tissue development [GO:0060612]; bone development [GO:0060348]; mesenchymal cell differentiation involved in kidney development [GO:0072161]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein ubiquitination [GO:0031398]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Q5JTD0	reviewed	TJAP1_HUMAN	Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4)	TJAP1 PILT TJP4	Homo sapiens (Human)	557	FUNCTION: Plays a role in regulating the structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q9DCD5}.		Golgi organization [GO:0007030]	bicellular tight junction [GO:0005923]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]		bicellular tight junction [GO:0005923]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; Golgi organization [GO:0007030]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9DCD5}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9DCD5}. Cell membrane {ECO:0000250|UniProtKB:Q9DCD5}; Peripheral membrane protein {ECO:0000305}. Note=Recruited to tight junctions (TJ) during late stages of maturation of the TJ complexes. Excluded from adherens junctions and desmosomes. {ECO:0000250|UniProtKB:Q9DCD5}.
Q5JTH9	reviewed	RRP12_HUMAN	RRP12-like protein	RRP12 KIAA0690	Homo sapiens (Human)	1297			rRNA processing [GO:0006364]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	RNA binding [GO:0003723]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5JTJ3	reviewed	COA6_HUMAN	Cytochrome c oxidase assembly factor 6 homolog	COA6 C1orf31	Homo sapiens (Human)	125	FUNCTION: Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. {ECO:0000269|PubMed:24549041, ECO:0000269|PubMed:25959673, ECO:0000269|PubMed:26160915}.		mitochondrial ATP synthesis coupled electron transport [GO:0042775]; plasma membrane ATP synthesis coupled electron transport [GO:0042774]; respiratory chain complex IV assembly [GO:0008535]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; respiratory chain complex IV [GO:0045277]	copper ion binding [GO:0005507]; RNA binding [GO:0003723]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; respiratory chain complex IV [GO:0045277]; copper ion binding [GO:0005507]; RNA binding [GO:0003723]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; plasma membrane ATP synthesis coupled electron transport [GO:0042774]; respiratory chain complex IV assembly [GO:0008535]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:25339201, ECO:0000269|PubMed:25959673}.
Q5JTV8	reviewed	TOIP1_HUMAN	Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B)	TOR1AIP1 LAP1	Homo sapiens (Human)	583	FUNCTION: Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}.	MISCELLANEOUS: [Isoform 4]: Produced by alternative promoter usage. {ECO:0000269|PubMed:25461922}.	nuclear membrane organization [GO:0071763]; positive regulation of ATP-dependent activity [GO:0032781]; protein localization to nuclear envelope [GO:0090435]; protein localization to nucleus [GO:0034504]	nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]	ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; cytoskeletal protein binding [GO:0008092]; lamin binding [GO:0005521]	nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; cytoskeletal protein binding [GO:0008092]; lamin binding [GO:0005521]; nuclear membrane organization [GO:0071763]; positive regulation of ATP-dependent activity [GO:0032781]; protein localization to nuclear envelope [GO:0090435]; protein localization to nucleus [GO:0034504]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:12061773, ECO:0000269|PubMed:24275647}; Single-pass membrane protein {ECO:0000269|PubMed:12061773, ECO:0000269|PubMed:24275647}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus envelope {ECO:0000269|PubMed:25461922}. Nucleus {ECO:0000269|PubMed:25461922}. Note=Found mainly in the nuclear envelope and also inside the nucleus. {ECO:0000269|PubMed:25461922}.
Q5JTW2	reviewed	CEP78_HUMAN	Centrosomal protein of 78 kDa (Cep78)	CEP78 C9orf81	Homo sapiens (Human)	689	FUNCTION: May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). May play a role in cilium biogenesis (PubMed:27588451). {ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27588451}.		cilium organization [GO:0044782]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; cilium organization [GO:0044782]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:27246242}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27588451}. Note=Mainly localizes at the centriolar wall, but also found in the pericentriolar material (PubMed:27246242). Expressed in photoreceptor inner segment (PubMed:27588452). {ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27588452}.
Q5JTY5	reviewed	ZNG1C_HUMAN	Zinc-regulated GTPase metalloprotein activator 1C (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 3) (COBW domain-containing protein 3)	ZNG1C CBWD3	Homo sapiens (Human)	395	FUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1C to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}.			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VEH6}.
Q5JTZ9	reviewed	SYAM_HUMAN	Alanine--tRNA ligase, mitochondrial (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)	AARS2 AARSL KIAA1270	Homo sapiens (Human)	985	FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. {ECO:0000255|HAMAP-Rule:MF_03133}.		alanyl-tRNA aminoacylation [GO:0006419]; mitochondrial alanyl-tRNA aminoacylation [GO:0070143]	mitochondrion [GO:0005739]	alanine-tRNA ligase activity [GO:0004813]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]	mitochondrion [GO:0005739]; alanine-tRNA ligase activity [GO:0004813]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; alanyl-tRNA aminoacylation [GO:0006419]; mitochondrial alanyl-tRNA aminoacylation [GO:0070143]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03133, ECO:0000269|PubMed:21549344}.
Q5JU85	reviewed	IQEC2_HUMAN	IQ motif and SEC7 domain-containing protein 2	IQSEC2 KIAA0522	Homo sapiens (Human)	1488	FUNCTION: Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins. {ECO:0000269|PubMed:26793055}.		actin cytoskeleton organization [GO:0030036]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of ARF protein signal transduction [GO:0032012]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]	cytoplasm [GO:0005737]; Schaffer collateral - CA1 synapse [GO:0098685]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; Schaffer collateral - CA1 synapse [GO:0098685]; guanyl-nucleotide exchange factor activity [GO:0005085]; actin cytoskeleton organization [GO:0030036]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of ARF protein signal transduction [GO:0032012]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q5JUK2	reviewed	SOLH1_HUMAN	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1	SOHLH1 C9orf157 NOHLH TEB2	Homo sapiens (Human)	328	FUNCTION: Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity). {ECO:0000250|UniProtKB:Q6IUP1, ECO:0000250|UniProtKB:Q9D489, ECO:0000269|PubMed:20506135}.		cell differentiation [GO:0030154]; oocyte differentiation [GO:0009994]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; cell differentiation [GO:0030154]; oocyte differentiation [GO:0009994]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6IUP1}. Nucleus {ECO:0000250|UniProtKB:Q6IUP1, ECO:0000255|PROSITE-ProRule:PRU00981}.
Q5JUK3	reviewed	KCNT1_HUMAN	Potassium channel subfamily T member 1 (KCa4.1)	KCNT1 KIAA1422	Homo sapiens (Human)	1230	FUNCTION: Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). {ECO:0000250}.		potassium ion transmembrane transport [GO:0071805]	plasma membrane [GO:0005886]	intracellular sodium activated potassium channel activity [GO:0005228]; outward rectifier potassium channel activity [GO:0015271]	plasma membrane [GO:0005886]; intracellular sodium activated potassium channel activity [GO:0005228]; outward rectifier potassium channel activity [GO:0015271]; potassium ion transmembrane transport [GO:0071805]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q5JVF3	reviewed	PCID2_HUMAN	PCI domain-containing protein 2 (CSN12-like protein)	PCID2 HT004	Homo sapiens (Human)	399	FUNCTION: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:22307388). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (PubMed:24896180). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity). {ECO:0000250|UniProtKB:Q8BFV2, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:24896180, ECO:0000305|PubMed:23591820}.		heterochromatin organization [GO:0070828]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of lymphoid progenitor cell differentiation [GO:1905457]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein transport [GO:0015031]; regulation of mRNA stability [GO:0043488]; spleen development [GO:0048536]; transcription elongation by RNA polymerase II [GO:0006368]	cytoplasm [GO:0005737]; nuclear pore nuclear basket [GO:0044615]; nucleus [GO:0005634]; transcription export complex 2 [GO:0070390]	double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear pore nuclear basket [GO:0044615]; nucleus [GO:0005634]; transcription export complex 2 [GO:0070390]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; heterochromatin organization [GO:0070828]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of lymphoid progenitor cell differentiation [GO:1905457]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein transport [GO:0015031]; regulation of mRNA stability [GO:0043488]; spleen development [GO:0048536]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23591820}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:23591820}.
Q5JVL4	reviewed	EFHC1_HUMAN	EF-hand domain-containing protein 1 (Myoclonin-1)	EFHC1	Homo sapiens (Human)	640	FUNCTION: Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization (PubMed:19734894, PubMed:28370826). Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (PubMed:22926142). May enhance calcium influx through CACNA1E and stimulate programmed cell death (PubMed:15258581, PubMed:19734894, PubMed:22926142, PubMed:28370826). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). {ECO:0000269|PubMed:15258581, ECO:0000269|PubMed:19734894, ECO:0000269|PubMed:22926142, ECO:0000269|PubMed:28370826, ECO:0000269|PubMed:36191189}.	MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.	cerebral cortex cell migration [GO:0021795]; cilium-dependent cell motility [GO:0060285]; mitotic cytokinesis [GO:0000281]; mitotic spindle organization [GO:0007052]; regulation of cell division [GO:0051302]	axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; centrosome [GO:0005813]; mitotic spindle [GO:0072686]; neuronal cell body [GO:0043025]; spindle pole [GO:0000922]	alpha-tubulin binding [GO:0043014]; calcium ion binding [GO:0005509]	axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; centrosome [GO:0005813]; mitotic spindle [GO:0072686]; neuronal cell body [GO:0043025]; spindle pole [GO:0000922]; alpha-tubulin binding [GO:0043014]; calcium ion binding [GO:0005509]; cerebral cortex cell migration [GO:0021795]; cilium-dependent cell motility [GO:0060285]; mitotic cytokinesis [GO:0000281]; mitotic spindle organization [GO:0007052]; regulation of cell division [GO:0051302]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22926142}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19734894, ECO:0000269|PubMed:22926142}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28370826}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q5JVS0	reviewed	HABP4_HUMAN	Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen)	HABP4	Homo sapiens (Human)	413	FUNCTION: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing (PubMed:14699138, PubMed:16455055, PubMed:21771594, PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000250|UniProtKB:Q5XJA5, ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:28695742}.	MISCELLANEOUS: Able to bind hyaluronan. However, its intracellular localization suggests that this interaction may not be relevant in vivo. {ECO:0000305}.; MISCELLANEOUS: The interaction with RACK1 is abolished upon activation of L540 tumor cells with PMA, which results in phosphorylation and exit of HABP4 from the nucleus. {ECO:0000269|PubMed:14699138}.	cellular response to mechanical stimulus [GO:0071260]; mRNA processing [GO:0006397]; negative regulation of DNA binding [GO:0043392]; PML body organization [GO:0030578]; positive regulation of RNA splicing [GO:0033120]; positive regulation of translational initiation [GO:0045948]; ribosome hibernation [GO:0141014]; RNA splicing [GO:0008380]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Gemini of coiled bodies [GO:0097504]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; sarcomere [GO:0030017]; sarcoplasm [GO:0016528]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SUMO binding [GO:0032183]; translation elongation factor binding [GO:0061770]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Gemini of coiled bodies [GO:0097504]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; sarcomere [GO:0030017]; sarcoplasm [GO:0016528]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SUMO binding [GO:0032183]; translation elongation factor binding [GO:0061770]; cellular response to mechanical stimulus [GO:0071260]; mRNA processing [GO:0006397]; negative regulation of DNA binding [GO:0043392]; PML body organization [GO:0030578]; positive regulation of RNA splicing [GO:0033120]; positive regulation of translational initiation [GO:0045948]; ribosome hibernation [GO:0141014]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:9523163}. Cytoplasm {ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:9523163}. Cytoplasm, Stress granule {ECO:0000269|PubMed:21771594}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A1L1K8}. Nucleus, nuclear body {ECO:0000269|PubMed:19523114}. Nucleus, nucleolus {ECO:0000269|PubMed:19523114}. Nucleus speckle {ECO:0000269|PubMed:19523114}. Nucleus, Cajal body {ECO:0000269|PubMed:19523114}. Nucleus, gem {ECO:0000269|PubMed:19523114}. Note=Transported into the nuclear compartment in activated leukocytes (PubMed:9523163). Inhibition of methylation alters its distribution between the nuclear and cytoplasmic compartments (PubMed:16879614, PubMed:19523114). Methylation may be required for its localization in subnuclear structures, such as nucleoli, nuclear speckles, Cajal bodies and Gemini of coiled bodies (gems) (PubMed:19523114). Colocalizes with FMR1, FXR1 and FXR2 in cytoplasmic stress granules (PubMed:21771594). In myocardial cells, localization at the sarcoplasm is reduced in response to mechanical stress (By similarity). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:9523163}.
Q5JWF2	reviewed	GNAS1_HUMAN	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas)	GNAS GNAS1	Homo sapiens (Human)	1037	FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). {ECO:0000250|UniProtKB:Q6R0H7}.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the ALEX protein from an overlapping reading frame. {ECO:0000250|UniProtKB:Q63803}.; MISCELLANEOUS: The GNAS locus is imprinted in a complex manner, giving rise to distinct paternally, maternally and biallelically expressed proteins. The XLas isoforms are paternally derived, the Gnas isoforms are biallelically derived and the Nesp55 isoforms are maternally derived.	adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone development [GO:0060348]; developmental growth [GO:0048589]; platelet aggregation [GO:0070527]; positive regulation of cold-induced thermogenesis [GO:0120162]; sensory perception of chemical stimulus [GO:0007606]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]	adenylate cyclase activator activity [GO:0010856]; beta-2 adrenergic receptor binding [GO:0031698]; corticotropin-releasing hormone receptor 1 binding [GO:0051430]; D1 dopamine receptor binding [GO:0031748]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; insulin-like growth factor receptor binding [GO:0005159]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; mu-type opioid receptor binding [GO:0031852]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; adenylate cyclase activator activity [GO:0010856]; beta-2 adrenergic receptor binding [GO:0031698]; corticotropin-releasing hormone receptor 1 binding [GO:0051430]; D1 dopamine receptor binding [GO:0031748]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; insulin-like growth factor receptor binding [GO:0005159]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; mu-type opioid receptor binding [GO:0031852]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone development [GO:0060348]; developmental growth [GO:0048589]; platelet aggregation [GO:0070527]; positive regulation of cold-induced thermogenesis [GO:0120162]; sensory perception of chemical stimulus [GO:0007606]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27120771}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63803}. Apical cell membrane {ECO:0000269|PubMed:27120771}.
Q5JX71	reviewed	F209A_HUMAN	Protein FAM209A	FAM209A C20orf106	Homo sapiens (Human)	171	FUNCTION: May play a role in sperm acrosome biogenesis. {ECO:0000250|UniProtKB:A2APA5}.	MISCELLANEOUS: The primate lineage appears to have undergone gene duplication of FAM209, such that humans contain FAM209A and FAM209B. {ECO:0000305}.	cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	extracellular exosome [GO:0070062]; nuclear inner membrane [GO:0005637]; nucleus [GO:0005634]		extracellular exosome [GO:0070062]; nuclear inner membrane [GO:0005637]; nucleus [GO:0005634]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:A2APA5}; Single-pass type I membrane protein {ECO:0000255}.
Q5JXC2	reviewed	MIIP_HUMAN	Migration and invasion-inhibitory protein (IGFBP2-binding protein) (Invasion-inhibitory protein 45) (IIp45)	MIIP IIP45	Homo sapiens (Human)	388	FUNCTION: Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. {ECO:0000269|PubMed:14617774}.		negative regulation of cell migration [GO:0030336]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]			negative regulation of cell migration [GO:0030336]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]	
Q5JY77	reviewed	GASP1_HUMAN	G-protein coupled receptor-associated sorting protein 1 (GASP-1)	GPRASP1 GASP KIAA0443	Homo sapiens (Human)	1395	FUNCTION: Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2. {ECO:0000269|PubMed:12142540, ECO:0000269|PubMed:15452121, ECO:0000269|PubMed:23954414}.		endosome to lysosome transport [GO:0008333]; G protein-coupled receptor catabolic process [GO:1990172]	cytosol [GO:0005829]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleus [GO:0005634]; endosome to lysosome transport [GO:0008333]; G protein-coupled receptor catabolic process [GO:1990172]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15452121}.
Q5JZY3	reviewed	EPHAA_HUMAN	Ephrin type-A receptor 10 (EC 2.7.10.1)	EPHA10	Homo sapiens (Human)	1008	FUNCTION: Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. {ECO:0000269|PubMed:15777695}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; phosphorylation [GO:0016310]	dendrite [GO:0030425]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; transmembrane-ephrin receptor activity [GO:0005005]	dendrite [GO:0030425]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; transmembrane-ephrin receptor activity [GO:0005005]; axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q5K4E3	reviewed	POLS2_HUMAN	Polyserase-2 (EC 3.4.21.-) (Polyserine protease 2) (Serine protease 36)	PRSS36	Homo sapiens (Human)	855	FUNCTION: Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1.		proteolysis [GO:0006508]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	serine-type endopeptidase activity [GO:0004252]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:15536082}. Note=Not attached to membranes.
Q5K4L6	reviewed	S27A3_HUMAN	Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3) (EC 6.2.1.-)	SLC27A3 ACSVL3 FATP3 PSEC0067 UNQ367/PRO703	Homo sapiens (Human)	683	FUNCTION: Mainly functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:23936004). Can mediate the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across membranes (By similarity). {ECO:0000250|UniProtKB:O88561, ECO:0000269|PubMed:23936004}.		fatty acid transport [GO:0015908]; long-chain fatty acid metabolic process [GO:0001676]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; fatty acid transport [GO:0015908]; long-chain fatty acid metabolic process [GO:0001676]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:23936004}; Single-pass membrane protein {ECO:0000255}.
Q5K651	reviewed	SAMD9_HUMAN	Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9)	SAMD9 C7orf5 DRIF1 KIAA2004 OEF1	Homo sapiens (Human)	1589	FUNCTION: Double-stranded nucleic acid binding that acts as a an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules (PubMed:25428864, PubMed:28157624). May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion. {ECO:0000269|PubMed:16960814, ECO:0000269|PubMed:18094730, ECO:0000269|PubMed:21160498, ECO:0000269|PubMed:24029230, ECO:0000269|PubMed:25428864, ECO:0000269|PubMed:28157624}.		endosomal vesicle fusion [GO:0034058]; innate immune response [GO:0045087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; endosomal vesicle fusion [GO:0034058]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16960814, ECO:0000269|PubMed:17407603, ECO:0000269|PubMed:25428864, ECO:0000269|PubMed:28157624}.
Q5KSL6	reviewed	DGKK_HUMAN	Diacylglycerol kinase kappa (DAG kinase kappa) (DGK-kappa) (EC 2.7.1.107) (142 kDa diacylglycerol kinase) (Diglyceride kinase kappa)	DGKK	Homo sapiens (Human)	1271	FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:16210324, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). {ECO:0000269|PubMed:16210324, ECO:0000269|PubMed:23949095, ECO:0000305}.		diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; response to oxidative stress [GO:0006979]	plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872]	plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872]; diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16210324}; Peripheral membrane protein {ECO:0000269|PubMed:16210324}.
Q5KU26	reviewed	COL12_HUMAN	Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin)	COLEC12 CLP1 NSR2 SCARA4 SRCL	Homo sapiens (Human)	742	FUNCTION: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:15845541, ECO:0000269|PubMed:16868960}.		carbohydrate mediated signaling [GO:0009756]; cellular response to exogenous dsRNA [GO:0071360]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; phagocytosis, recognition [GO:0006910]; plasma membrane raft organization [GO:0044857]; toll-like receptor 3 signaling pathway [GO:0034138]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle membrane [GO:0030666]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]	galactose binding [GO:0005534]; low-density lipoprotein particle binding [GO:0030169]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle membrane [GO:0030666]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; galactose binding [GO:0005534]; low-density lipoprotein particle binding [GO:0030169]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; carbohydrate mediated signaling [GO:0009756]; cellular response to exogenous dsRNA [GO:0071360]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; phagocytosis, recognition [GO:0006910]; plasma membrane raft organization [GO:0044857]; toll-like receptor 3 signaling pathway [GO:0034138]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269|PubMed:11162630}. Note=Forms clusters on the cell surface.
Q5M775	reviewed	CYTSB_HUMAN	Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1)	SPECC1 CYTSB NSP5	Homo sapiens (Human)	1068			actin cytoskeleton organization [GO:0030036]; associative learning [GO:0008306]; blastocyst development [GO:0001824]	apical part of cell [GO:0045177]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; filamentous actin [GO:0031941]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]		apical part of cell [GO:0045177]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; filamentous actin [GO:0031941]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; actin cytoskeleton organization [GO:0030036]; associative learning [GO:0008306]; blastocyst development [GO:0001824]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15602574}.; SUBCELLULAR LOCATION: [Isoform 3]: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Q5M7Z0	reviewed	RNFT1_HUMAN	E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1)	RNFT1 PTD016	Homo sapiens (Human)	435	FUNCTION: E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. {ECO:0000269|PubMed:27485036}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	positive regulation of ERAD pathway [GO:1904294]; protein autoubiquitination [GO:0051865]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of ERAD pathway [GO:1904294]; protein autoubiquitination [GO:0051865]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27485036}; Multi-pass membrane protein {ECO:0000305}.
Q5M8T2	reviewed	S35D3_HUMAN	Solute carrier family 35 member D3 (Fringe connection-like protein 1)	SLC35D3 FRCL1	Homo sapiens (Human)	416	FUNCTION: Probable UDP-glucose transmembrane transporter involved in UDP-glucose transport from the cytosol to the lumen of synaptic vesicles (PubMed:34269178). It is involved in platelet dense granules maturation (By similarity). {ECO:0000250|UniProtKB:Q8BGF8, ECO:0000269|PubMed:34269178}.; FUNCTION: Alternatively, could function as a molecular adapter enhancing the formation of the PI3KC3-C1/AIC/autophagy initiation complex to promote autophagy in dopaminergic neurons. Could also regulate the plasma membrane localization of the D(1A) dopamine receptor/DRD1 and dopamine signaling. {ECO:0000250|UniProtKB:Q8BGF8}.		carbohydrate transport [GO:0008643]; energy homeostasis [GO:0097009]; platelet dense granule organization [GO:0060155]; positive regulation of autophagy [GO:0010508]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; protein exit from endoplasmic reticulum [GO:0032527]; UDP-glucose transmembrane transport [GO:0015786]	early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; synaptic vesicle membrane [GO:0030672]	antiporter activity [GO:0015297]; protein-macromolecule adaptor activity [GO:0030674]; UDP-glucose transmembrane transporter activity [GO:0005460]	early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; synaptic vesicle membrane [GO:0030672]; antiporter activity [GO:0015297]; protein-macromolecule adaptor activity [GO:0030674]; UDP-glucose transmembrane transporter activity [GO:0005460]; carbohydrate transport [GO:0008643]; energy homeostasis [GO:0097009]; platelet dense granule organization [GO:0060155]; positive regulation of autophagy [GO:0010508]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; protein exit from endoplasmic reticulum [GO:0032527]; UDP-glucose transmembrane transport [GO:0015786]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:34269178}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q8BGF8}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BGF8}; Multi-pass membrane protein {ECO:0000255}. Note=Active at early endosome membrane in the biosynthesis of mature platelet-dense granules. {ECO:0000250|UniProtKB:Q8BGF8}.
Q5MIZ7	reviewed	P4R3B_HUMAN	Serine/threonine-protein phosphatase 4 regulatory subunit 3B (SMEK homolog 2)	PPP4R3B KIAA1387 PP4R3B SMEK2	Homo sapiens (Human)	849	FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers.	MISCELLANEOUS: [Isoform 4]: May be due to intron retention. {ECO:0000305}.	DNA damage response [GO:0006974]; gluconeogenesis [GO:0006094]; positive regulation of gluconeogenesis [GO:0045722]; regulation of double-strand break repair [GO:2000779]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein phosphatase 4 complex [GO:0030289]	protein phosphatase activator activity [GO:0072542]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein phosphatase 4 complex [GO:0030289]; protein phosphatase activator activity [GO:0072542]; DNA damage response [GO:0006974]; gluconeogenesis [GO:0006094]; positive regulation of gluconeogenesis [GO:0045722]; regulation of double-strand break repair [GO:2000779]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18487071}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18487071}. Nucleus {ECO:0000269|PubMed:18487071}. Note=In interphase localized in the cytoplasm and (with higher levels) the nucleus. During metaphase located in pericentriolar regions.
Q5MJ10	reviewed	SPXN2_HUMAN	Sperm protein associated with the nucleus on the X chromosome N2 (Nuclear-associated protein SPAN-Xn2) (SPANX-N2) (SPANX family member N2)	SPANXN2	Homo sapiens (Human)	180							
Q5MJ70	reviewed	SPDYA_HUMAN	Speedy protein A (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1)	SPDYA SPDY1 SPY1	Homo sapiens (Human)	313	FUNCTION: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995). Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962). {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12839962, ECO:0000269|PubMed:12972555, ECO:0000269|PubMed:28666995}.		DNA damage response [GO:0006974]; establishment of protein localization to telomere [GO:0070200]; G1/S transition of mitotic cell cycle [GO:0000082]; male meiotic nuclear division [GO:0007140]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; oogenesis [GO:0048477]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein kinase activity [GO:0045860]; spermatogenesis [GO:0007283]; telomere capping [GO:0016233]	chromosome, telomeric region [GO:0000781]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; XY body [GO:0001741]	protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]	chromosome, telomeric region [GO:0000781]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; XY body [GO:0001741]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; DNA damage response [GO:0006974]; establishment of protein localization to telomere [GO:0070200]; G1/S transition of mitotic cell cycle [GO:0000082]; male meiotic nuclear division [GO:0007140]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; oogenesis [GO:0048477]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein kinase activity [GO:0045860]; spermatogenesis [GO:0007283]; telomere capping [GO:0016233]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12972555}.
Q5MNZ6	reviewed	WIPI3_HUMAN	WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein)	WDR45B WDR45L WIPI3	Homo sapiens (Human)	344	FUNCTION: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066, PubMed:30797857). In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed:28503735). {ECO:0000269|PubMed:28503735, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30797857}.		autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; nucleophagy [GO:0044804]; protein localization to phagophore assembly site [GO:0034497]	cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; lysosome [GO:0005764]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]	phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; TSC1-TSC2 complex binding [GO:0062078]	cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; lysosome [GO:0005764]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; TSC1-TSC2 complex binding [GO:0062078]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; nucleophagy [GO:0044804]; protein localization to phagophore assembly site [GO:0034497]	SUBCELLULAR LOCATION: Preautophagosomal structure {ECO:0000269|PubMed:28561066}. Lysosome {ECO:0000269|PubMed:28561066}.
Q5MNZ9	reviewed	WIPI1_HUMAN	WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (Atg18 protein homolog) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa)	WIPI1 WIPI49	Homo sapiens (Human)	446	FUNCTION: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:15602573, PubMed:20114074, PubMed:20484055, PubMed:20639694, PubMed:23088497, PubMed:28561066, PubMed:31271352). Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy (PubMed:28561066). Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes (PubMed:28561066, PubMed:31271352, PubMed:33499712). There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:28561066). Together with WDR45/WIPI4, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Involved in xenophagy of Staphylococcus aureus (PubMed:22829830). Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation (PubMed:22829830). Also plays a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy (PubMed:21317285). May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway (PubMed:15020712). {ECO:0000269|PubMed:15020712, ECO:0000269|PubMed:15602573, ECO:0000269|PubMed:20114074, ECO:0000269|PubMed:20484055, ECO:0000269|PubMed:20639694, ECO:0000269|PubMed:21317285, ECO:0000269|PubMed:22829830, ECO:0000269|PubMed:23088497, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:31271352, ECO:0000269|PubMed:33499712}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; nucleophagy [GO:0044804]; positive regulation of autophagosome assembly [GO:2000786]; protein localization to phagophore assembly site [GO:0034497]; vesicle targeting, trans-Golgi to endosome [GO:0048203]	autophagosome membrane [GO:0000421]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extrinsic component of membrane [GO:0019898]; Golgi membrane [GO:0000139]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; trans-Golgi network [GO:0005802]	nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]	autophagosome membrane [GO:0000421]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extrinsic component of membrane [GO:0019898]; Golgi membrane [GO:0000139]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; trans-Golgi network [GO:0005802]; nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; nucleophagy [GO:0044804]; positive regulation of autophagosome assembly [GO:2000786]; protein localization to phagophore assembly site [GO:0034497]; vesicle targeting, trans-Golgi to endosome [GO:0048203]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Preautophagosomal structure membrane {ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:33499712}; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules.
Q5MY95	reviewed	ENTP8_HUMAN	Ectonucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) (NTPDase 8) (NTPDase8) (EC 3.6.1.5)	ENTPD8 UNQ2492/PRO5779	Homo sapiens (Human)	495	FUNCTION: Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. {ECO:0000269|PubMed:16752921, ECO:0000269|PubMed:17095758}.		nucleoside diphosphate biosynthetic process [GO:0009133]; nucleoside diphosphate catabolic process [GO:0009134]; nucleoside monophosphate biosynthetic process [GO:0009124]	plasma membrane [GO:0005886]	ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; metal ion binding [GO:0046872]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]	plasma membrane [GO:0005886]; ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; metal ion binding [GO:0046872]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]; nucleoside diphosphate biosynthetic process [GO:0009133]; nucleoside diphosphate catabolic process [GO:0009134]; nucleoside monophosphate biosynthetic process [GO:0009124]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q5NDL2	reviewed	EOGT_HUMAN	EGF domain-specific O-linked N-acetylglucosamine transferase (EC 2.4.1.255) (Extracellular O-linked N-acetylglucosamine transferase)	EOGT AER61 C3orf64 EOGT1	Homo sapiens (Human)	527	FUNCTION: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. {ECO:0000269|PubMed:23671640}.		protein O-GlcNAcylation via threonine [GO:0097370]; protein O-linked glycosylation [GO:0006493]	endoplasmic reticulum lumen [GO:0005788]	protein O-acetylglucosaminyltransferase activity [GO:0097363]	endoplasmic reticulum lumen [GO:0005788]; protein O-acetylglucosaminyltransferase activity [GO:0097363]; protein O-GlcNAcylation via threonine [GO:0097370]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q5NUL3	reviewed	FFAR4_HUMAN	Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1)	FFAR4 GPR120 GPR129 O3FAR1 PGR4	Homo sapiens (Human)	361	FUNCTION: [Isoform 2]: G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways (PubMed:22282525, PubMed:24742677, PubMed:27852822, PubMed:24817122, PubMed:22343897). LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs) (PubMed:27852822, PubMed:22343897, PubMed:22282525, PubMed:24742677). After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed:22282525, PubMed:24817122). In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation (By similarity). Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry (By similarity). Induces differentiation of brown adipocytes probably via autocrine and endocrine functions of FGF21 hormone (By similarity). Activates brown adipocytes by initiating intracellular calcium signaling that leads to mitochondrial depolarization and fission, and overall increased mitochondrial respiration (By similarity). Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass (By similarity). Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins (By similarity). In response to dietary fats regulates hormone secretion and appetite (By similarity). Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels (By similarity). Negatively regulates glucose-induced SST secretion in pancreatic delta cells (By similarity). Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone (By similarity). In taste buds, contributes to sensing of dietary fatty acids by the gustatory system (By similarity). During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue (By similarity). Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation (PubMed:23809162). In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1 (By similarity). Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of pro-inflammatory cytokine release (PubMed:23809162). Mediates LCFAs anti-apoptotic effects (By similarity). {ECO:0000250|UniProtKB:Q7TMA4, ECO:0000269|PubMed:22282525, ECO:0000269|PubMed:22343897, ECO:0000269|PubMed:23809162, ECO:0000269|PubMed:24742677, ECO:0000269|PubMed:24817122, ECO:0000269|PubMed:27852822}.; FUNCTION: [Isoform 1]: Receptor for LCFAs decoupled from G-protein signaling. May signal through beta-arrestin pathway. After LCFAs binding, associates with beta-arrestin ARRB2 that may act as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis. {ECO:0000269|PubMed:22282525}.		brown fat cell differentiation [GO:0050873]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; ghrelin secretion [GO:0036321]; hormone secretion [GO:0046879]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytokine production [GO:0001818]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of somatostatin secretion [GO:0090275]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucagon secretion [GO:0070094]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of glucose transmembrane transport [GO:0010827]; white fat cell differentiation [GO:0050872]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	arrestin family protein binding [GO:1990763]; fatty acid binding [GO:0005504]; G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]; taste receptor activity [GO:0008527]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; arrestin family protein binding [GO:1990763]; fatty acid binding [GO:0005504]; G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]; taste receptor activity [GO:0008527]; brown fat cell differentiation [GO:0050873]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; ghrelin secretion [GO:0036321]; hormone secretion [GO:0046879]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytokine production [GO:0001818]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of somatostatin secretion [GO:0090275]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucagon secretion [GO:0070094]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of glucose transmembrane transport [GO:0010827]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:22282525}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:22282525}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:22282525}; Multi-pass membrane protein {ECO:0000255}. Note=Sorted to late endosome/lysosome compartments upon internalization. {ECO:0000269|PubMed:22282525}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:22282525}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:22282525}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:22282525}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000305|PubMed:31761534}; Multi-pass membrane protein {ECO:0000255}. Note=Sorted to late endosome/lysosome compartments upon internalization (PubMed:22282525). Specifically localizes to the primary cilium of undifferentiated adipocytes. Ciliary trafficking is TULP3-dependent. As the cilium is lost during adipogenesis, moves to the plasma membrane (Probable). {ECO:0000269|PubMed:22282525, ECO:0000305|PubMed:31761534}.
Q5PRF9	reviewed	SMAG2_HUMAN	Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B)	SAMD4B SMAUG2	Homo sapiens (Human)	694	FUNCTION: Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}.		nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]	cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation repressor activity [GO:0030371]	cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation repressor activity [GO:0030371]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20510020}. Nucleus {ECO:0000269|PubMed:20510020}.
Q5PSV4	reviewed	BRM1L_HUMAN	Breast cancer metastasis-suppressor 1-like protein (BRMS1-homolog protein p40) (BRMS1-like protein p40)	BRMS1L	Homo sapiens (Human)	323	FUNCTION: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth. {ECO:0000269|PubMed:15451426}.		negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]	nucleus [GO:0005634]; Sin3 complex [GO:0016580]; Sin3-type complex [GO:0070822]	histone deacetylase binding [GO:0042826]	nucleus [GO:0005634]; Sin3 complex [GO:0016580]; Sin3-type complex [GO:0070822]; histone deacetylase binding [GO:0042826]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5QGS0	reviewed	NEXMI_HUMAN	Neurite extension and migration factor (XLMR protein related to neurite extension) (XPN)	NEXMIF KIAA2022	Homo sapiens (Human)	1516	FUNCTION: Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1). {ECO:0000250|UniProtKB:D3ZGX1}.		negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron migration [GO:2001223]; nervous system development [GO:0007399]	cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron migration [GO:2001223]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24071057}. Cytoplasm {ECO:0000250|UniProtKB:Q5DTT1}.
Q5QGT7	reviewed	RTP2_HUMAN	Receptor-transporting protein 2 (3CxxC-type zinc finger protein 2)	RTP2 Z3CXXC2	Homo sapiens (Human)	225	FUNCTION: Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs. {ECO:0000250}.		detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Note=Effective cell surface expression depends upon interaction with olfactory receptors. {ECO:0000250}.
Q5QGZ9	reviewed	CL12A_HUMAN	C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371)	CLEC12A CLL1 DCAL2 MICL	Homo sapiens (Human)	265	FUNCTION: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:16239426}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	signal transduction [GO:0007165]	plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	carbohydrate binding [GO:0030246]; signaling receptor regulator activity [GO:0030545]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; carbohydrate binding [GO:0030246]; signaling receptor regulator activity [GO:0030545]; transmembrane signaling receptor activity [GO:0004888]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}; Single-pass type II membrane protein {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}. Note=Ligand binding leads to internalization.
Q5QJE6	reviewed	TDIF2_HUMAN	Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)	DNTTIP2 ERBP TDIF2	Homo sapiens (Human)	756	FUNCTION: Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}.		ribosomal small subunit biogenesis [GO:0042274]; RNA processing [GO:0006396]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; ribosomal small subunit biogenesis [GO:0042274]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
Q5QJU3	reviewed	ACER2_HUMAN	Alkaline ceramidase 2 (AlkCDase 2) (Alkaline CDase 2) (haCER2) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 3-like) (N-acylsphingosine amidohydrolase 3-like)	ACER2 ASAH3L PP11646	Homo sapiens (Human)	275	FUNCTION: Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20207939). Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates (PubMed:20089856). Also hydrolyzes dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate (PubMed:16940153, PubMed:26943039, PubMed:28294157, PubMed:29229990). As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage (PubMed:26943039, PubMed:28294157, PubMed:29229990). Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (PubMed:18945876). {ECO:0000250|UniProtKB:Q8VD53, ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:18945876, ECO:0000269|PubMed:20089856, ECO:0000269|PubMed:20207939, ECO:0000269|PubMed:20628055, ECO:0000269|PubMed:26943039, ECO:0000269|PubMed:28294157, ECO:0000269|PubMed:29229990, ECO:0000303|PubMed:20207939}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cellular response to xenobiotic stimulus [GO:0071466]; ceramide catabolic process [GO:0046514]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell-matrix adhesion [GO:0001953]; positive regulation of cell population proliferation [GO:0008284]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of protein glycosylation [GO:0060049]; response to retinoic acid [GO:0032526]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	ceramidase activity [GO:0102121]; dihydroceramidase activity [GO:0071633]; metal ion binding [GO:0046872]; N-acylsphingosine amidohydrolase activity [GO:0017040]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; ceramidase activity [GO:0102121]; dihydroceramidase activity [GO:0071633]; metal ion binding [GO:0046872]; N-acylsphingosine amidohydrolase activity [GO:0017040]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cellular response to xenobiotic stimulus [GO:0071466]; ceramide catabolic process [GO:0046514]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell-matrix adhesion [GO:0001953]; positive regulation of cell population proliferation [GO:0008284]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of protein glycosylation [GO:0060049]; response to retinoic acid [GO:0032526]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:20089856}; Multi-pass membrane protein {ECO:0000269|PubMed:20089856}.
Q5QNW6	reviewed	H2B2F_HUMAN	Histone H2B type 2-F (H2B-clustered histone 18)	H2BC18 HIST2H2BF	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.			cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q5QP82	reviewed	DCA10_HUMAN	DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32)	DCAF10 WDR32	Homo sapiens (Human)	559	FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}.		protein ubiquitination [GO:0016567]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654]; protein ubiquitination [GO:0016567]	
Q5R372	reviewed	RBG1L_HUMAN	Rab GTPase-activating protein 1-like	RABGAP1L HHL KIAA0471	Homo sapiens (Human)	815	FUNCTION: GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}.		endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880]	early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:A6H6A9}. Early endosome {ECO:0000269|PubMed:16923123}. Golgi apparatus {ECO:0000269|PubMed:16923123}. Note=Colocalizes on endosomes partially with EEA1 (PubMed:16923123). Colocalizes and cotransports on motile vesicles with ANK2 (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}.
Q5R3F8	reviewed	PPR29_HUMAN	Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62)	ELFN2 KIAA1904 LRRC62 PPP1R29	Homo sapiens (Human)	820	FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.			extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]	protein phosphatase inhibitor activity [GO:0004864]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; protein phosphatase inhibitor activity [GO:0004864]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5RI15	reviewed	COX20_HUMAN	Cytochrome c oxidase assembly protein COX20, mitochondrial	COX20 FAM36A	Homo sapiens (Human)	118	FUNCTION: Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:23125284). Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme (PubMed:24403053). {ECO:0000269|PubMed:23125284, ECO:0000269|PubMed:24403053}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; mitochondrial cytochrome c oxidase assembly [GO:0033617]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:23125284, ECO:0000269|PubMed:29154948}; Multi-pass membrane protein {ECO:0000255}.
Q5RKV6	reviewed	EXOS6_HUMAN	Exosome complex component MTR3 (Exosome component 6) (mRNA transport regulator 3 homolog) (hMtr3) (p11)	EXOSC6 MTR3	Homo sapiens (Human)	272	FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. {ECO:0000269|PubMed:21255825}.		DNA deamination [GO:0045006]; isotype switching [GO:0045190]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of isotype switching [GO:0045830]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; DNA deamination [GO:0045006]; isotype switching [GO:0045190]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of isotype switching [GO:0045830]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Nucleus {ECO:0000305}.
Q5RL73	reviewed	RBM48_HUMAN	RNA-binding protein 48	RBM48 C7orf64 HSPC304	Homo sapiens (Human)	367	FUNCTION: As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. {ECO:0000305|PubMed:33509932}.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	
Q5S007	reviewed	LRRK2_HUMAN	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	LRRK2 PARK8	Homo sapiens (Human)	2527	FUNCTION: Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:20949042, PubMed:22012985, PubMed:26824392, PubMed:27830463, PubMed:29125462, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:30635421, PubMed:21850687, PubMed:23395371, PubMed:17114044, PubMed:24687852, PubMed:26014385, PubMed:25201882). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421, PubMed:23395371). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:29212815). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421}.		autophagy [GO:0006914]; calcium-mediated signaling [GO:0019722]; canonical Wnt signaling pathway [GO:0060070]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; endoplasmic reticulum organization [GO:0007029]; excitatory postsynaptic potential [GO:0060079]; exploration behavior [GO:0035640]; Golgi organization [GO:0007030]; GTP metabolic process [GO:0046039]; intracellular distribution of mitochondria [GO:0048312]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; locomotory exploration behavior [GO:0035641]; lysosome organization [GO:0007040]; MAPK cascade [GO:0000165]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of GTPase activity [GO:0034260]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein binding [GO:0032091]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein processing [GO:0010955]; negative regulation of protein processing involved in protein targeting to mitochondrion [GO:1903217]; negative regulation of protein targeting to mitochondrion [GO:1903215]; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [GO:1903125]; neuromuscular junction development [GO:0007528]; neuron projection arborization [GO:0140058]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of tumor necrosis factor production [GO:0032760]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to mitochondrion [GO:0070585]; protein phosphorylation [GO:0006468]; regulation of autophagy [GO:0010506]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of CAMKK-AMPK signaling cascade [GO:1905289]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of kidney size [GO:0035564]; regulation of locomotion [GO:0040012]; regulation of lysosomal lumen pH [GO:0035751]; regulation of membrane potential [GO:0042391]; regulation of mitochondrial depolarization [GO:0051900]; regulation of mitochondrial fission [GO:0090140]; regulation of neuroblast proliferation [GO:1902692]; regulation of neuron maturation [GO:0014041]; regulation of protein kinase A signaling [GO:0010738]; regulation of protein stability [GO:0031647]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle transport [GO:1902803]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283]; striatum development [GO:0021756]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; Wnt signalosome assembly [GO:1904887]	amphisome [GO:0044753]; autolysosome [GO:0044754]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; caveola neck [GO:0099400]; cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane raft [GO:0045121]; microvillus [GO:0005902]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body, internal vesicle [GO:0097487]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic cytosol [GO:0099523]; ribonucleoprotein complex [GO:1990904]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; trans-Golgi network [GO:0005802]; Wnt signalosome [GO:1990909]	actin binding [GO:0003779]; ATP binding [GO:0005524]; beta-catenin destruction complex binding [GO:1904713]; clathrin binding [GO:0030276]; co-receptor binding [GO:0039706]; GTP binding [GO:0005525]; GTP-dependent protein kinase activity [GO:0034211]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; microtubule binding [GO:0008017]; peroxidase inhibitor activity [GO:0036479]; protein homodimerization activity [GO:0042803]; protein kinase A binding [GO:0051018]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor binding [GO:0005102]; signaling receptor complex adaptor activity [GO:0030159]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]; transmembrane transporter binding [GO:0044325]; tubulin binding [GO:0015631]	amphisome [GO:0044753]; autolysosome [GO:0044754]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; caveola neck [GO:0099400]; cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane raft [GO:0045121]; microvillus [GO:0005902]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body, internal vesicle [GO:0097487]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic cytosol [GO:0099523]; ribonucleoprotein complex [GO:1990904]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; trans-Golgi network [GO:0005802]; Wnt signalosome [GO:1990909]; actin binding [GO:0003779]; ATP binding [GO:0005524]; beta-catenin destruction complex binding [GO:1904713]; clathrin binding [GO:0030276]; co-receptor binding [GO:0039706]; GTP binding [GO:0005525]; GTP-dependent protein kinase activity [GO:0034211]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; microtubule binding [GO:0008017]; peroxidase inhibitor activity [GO:0036479]; protein homodimerization activity [GO:0042803]; protein kinase A binding [GO:0051018]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor binding [GO:0005102]; signaling receptor complex adaptor activity [GO:0030159]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]; transmembrane transporter binding [GO:0044325]; tubulin binding [GO:0015631]; autophagy [GO:0006914]; calcium-mediated signaling [GO:0019722]; canonical Wnt signaling pathway [GO:0060070]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; endoplasmic reticulum organization [GO:0007029]; excitatory postsynaptic potential [GO:0060079]; exploration behavior [GO:0035640]; Golgi organization [GO:0007030]; GTP metabolic process [GO:0046039]; intracellular distribution of mitochondria [GO:0048312]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; locomotory exploration behavior [GO:0035641]; lysosome organization [GO:0007040]; MAPK cascade [GO:0000165]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of GTPase activity [GO:0034260]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein binding [GO:0032091]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein processing [GO:0010955]; negative regulation of protein processing involved in protein targeting to mitochondrion [GO:1903217]; negative regulation of protein targeting to mitochondrion [GO:1903215]; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [GO:1903125]; neuromuscular junction development [GO:0007528]; neuron projection arborization [GO:0140058]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of tumor necrosis factor production [GO:0032760]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to mitochondrion [GO:0070585]; protein phosphorylation [GO:0006468]; regulation of autophagy [GO:0010506]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of CAMKK-AMPK signaling cascade [GO:1905289]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of kidney size [GO:0035564]; regulation of locomotion [GO:0040012]; regulation of lysosomal lumen pH [GO:0035751]; regulation of membrane potential [GO:0042391]; regulation of mitochondrial depolarization [GO:0051900]; regulation of mitochondrial fission [GO:0090140]; regulation of neuroblast proliferation [GO:1902692]; regulation of neuron maturation [GO:0014041]; regulation of protein kinase A signaling [GO:0010738]; regulation of protein stability [GO:0031647]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle transport [GO:1902803]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283]; striatum development [GO:0021756]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; Wnt signalosome assembly [GO:1904887]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:16321986, ECO:0000269|PubMed:16352719, ECO:0000269|PubMed:26014385}. Perikaryon {ECO:0000269|PubMed:17120249}. Golgi apparatus membrane {ECO:0000269|PubMed:16321986, ECO:0000269|PubMed:23395371}; Peripheral membrane protein {ECO:0000269|PubMed:16321986}. Cell projection, axon {ECO:0000269|PubMed:17120249}. Cell projection, dendrite {ECO:0000269|PubMed:17120249, ECO:0000269|PubMed:21850687}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16321986, ECO:0000269|PubMed:25201882}; Peripheral membrane protein {ECO:0000269|PubMed:16321986}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:24687852}. Endosome {ECO:0000250|UniProtKB:Q5S006}. Lysosome {ECO:0000269|PubMed:17120249}. Mitochondrion outer membrane {ECO:0000269|PubMed:16269541, ECO:0000269|PubMed:16321986, ECO:0000269|PubMed:17120249, ECO:0000269|PubMed:29212815}; Peripheral membrane protein {ECO:0000269|PubMed:16269541, ECO:0000269|PubMed:16321986, ECO:0000269|PubMed:17120249, ECO:0000269|PubMed:29212815}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:35266954}. Note=Colocalized with RAB29 along tubular structures emerging from Golgi apparatus (PubMed:23395371). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:25201882). {ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:25201882}.
Q5SGD2	reviewed	PPM1L_HUMAN	Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon)	PPM1L PP2CE	Homo sapiens (Human)	360	FUNCTION: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. {ECO:0000269|PubMed:17456047}.		MAPK cascade [GO:0000165]; sphingolipid biosynthetic process [GO:0030148]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; MAPK cascade [GO:0000165]; sphingolipid biosynthetic process [GO:0030148]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q5SNT2	reviewed	TM201_HUMAN	Transmembrane protein 201 (Spindle-associated membrane protein 1)	TMEM201 NET5 SAMP1	Homo sapiens (Human)	666	FUNCTION: Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}.		centrosome localization [GO:0051642]; fibroblast migration [GO:0010761]; nuclear envelope organization [GO:0006998]; nuclear migration along microtubule [GO:0030473]; protein localization to nuclear envelope [GO:0090435]	cytoplasm [GO:0005737]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; spindle pole [GO:0000922]	actin filament binding [GO:0051015]; lamin binding [GO:0005521]	cytoplasm [GO:0005737]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; spindle pole [GO:0000922]; actin filament binding [GO:0051015]; lamin binding [GO:0005521]; centrosome localization [GO:0051642]; fibroblast migration [GO:0010761]; nuclear envelope organization [GO:0006998]; nuclear migration along microtubule [GO:0030473]; protein localization to nuclear envelope [GO:0090435]	SUBCELLULAR LOCATION: [Isoform 2]: Nucleus inner membrane {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}; Multi-pass membrane protein {ECO:0000269|PubMed:19494128}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19494128}. Note=The C-terminal of isoform 2 is located on the nucleoplasmic side. During interphase, isoform 2 is distributed in the inner nuclear membrane in distinct micro-domains and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle. {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}.
Q5SQ64	reviewed	LY66F_HUMAN	Lymphocyte antigen 6 complex locus protein G6f	LY6G6F C6orf21 G6F LY6G6D NG32	Homo sapiens (Human)	297	FUNCTION: May play a role in the downstream signal transduction pathways involving GRB2 and GRB7. {ECO:0000269|PubMed:12852788}.			plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]		plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12852788}; Single-pass type I membrane protein {ECO:0000269|PubMed:12852788}.
Q5SQI0	reviewed	ATAT_HUMAN	Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog)	ATAT1 C6orf134 MEC17 Nbla00487	Homo sapiens (Human)	421	FUNCTION: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:20829795, ECO:0000269|PubMed:21068373, ECO:0000269|PubMed:24097348, ECO:0000269|PubMed:24906155}.		alpha-tubulin acetylation [GO:0071929]; cilium assembly [GO:0060271]; dentate gyrus development [GO:0021542]; microtubule cytoskeleton organization [GO:0000226]; neuron development [GO:0048666]; NLRP3 inflammasome complex assembly [GO:0044546]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of fat cell differentiation [GO:0045598]; regulation of microtubule cytoskeleton organization [GO:0070507]; response to mechanical stimulus [GO:0009612]; response to pain [GO:0048265]; spermatogenesis [GO:0007283]	axon [GO:0030424]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule bundle [GO:0097427]; mitotic spindle [GO:0072686]	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; tubulin N-acetyltransferase activity [GO:0019799]	axon [GO:0030424]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule bundle [GO:0097427]; mitotic spindle [GO:0072686]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; tubulin N-acetyltransferase activity [GO:0019799]; alpha-tubulin acetylation [GO:0071929]; cilium assembly [GO:0060271]; dentate gyrus development [GO:0021542]; microtubule cytoskeleton organization [GO:0000226]; neuron development [GO:0048666]; NLRP3 inflammasome complex assembly [GO:0044546]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of fat cell differentiation [GO:0045598]; regulation of microtubule cytoskeleton organization [GO:0070507]; response to mechanical stimulus [GO:0009612]; response to pain [GO:0048265]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:24097348}. Membrane, clathrin-coated pit {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:24097348}. Cell junction, focal adhesion {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:24097348}. Cell projection, axon {ECO:0000255|HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton, spindle {ECO:0000255|HAMAP-Rule:MF_03130}.
Q5SQN1	reviewed	SNP47_HUMAN	Synaptosomal-associated protein 47 (SNAP-47) (Epididymis luminal protein 170) (Synaptosomal-associated 47 kDa protein)	SNAP47 C1orf142 HEL170 SVAP1	Homo sapiens (Human)	464	FUNCTION: Plays a role in intracellular membrane fusion. {ECO:0000250}.		exocytosis [GO:0006887]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]	endomembrane system [GO:0012505]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201]	SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]	endomembrane system [GO:0012505]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201]; SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]; exocytosis [GO:0006887]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Appears to be exclusively membrane-bound. {ECO:0000250}.
Q5SQQ9	reviewed	VAX1_HUMAN	Ventral anterior homeobox 1	VAX1	Homo sapiens (Human)	334	FUNCTION: Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity). {ECO:0000250}.		astrocyte differentiation [GO:0048708]; axon guidance [GO:0007411]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; central nervous system development [GO:0007417]; negative regulation of neuroblast proliferation [GO:0007406]; neuroblast proliferation [GO:0007405]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal muscle cell differentiation [GO:0035914]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; sequence-specific double-stranded DNA binding [GO:1990837]; astrocyte differentiation [GO:0048708]; axon guidance [GO:0007411]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; central nervous system development [GO:0007417]; negative regulation of neuroblast proliferation [GO:0007406]; neuroblast proliferation [GO:0007405]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q5SR56	reviewed	MF14B_HUMAN	Hippocampus abundant transcript-like protein 1 (Major facilitator superfamily domain-containing 14B)	MFSD14B HIATL1	Homo sapiens (Human)	506				membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5SRE5	reviewed	NU188_HUMAN	Nucleoporin NUP188 (hNup188)	NUP188 KIAA0169	Homo sapiens (Human)	1749	FUNCTION: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}.		mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611]; structural constituent of nuclear pore [GO:0017056]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000305|PubMed:32275884}.
Q5SRE7	reviewed	PHYD1_HUMAN	Phytanoyl-CoA dioxygenase domain-containing protein 1 (Protein PHYHD1) (EC 1.14.11.-)	PHYHD1	Homo sapiens (Human)	291	FUNCTION: 2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron-dependent manner (PubMed:21530488). However, does not couple 2OG turnover to the hydroxylation of acyl-coenzyme A derivatives, implying that it is not directly involved in phytanoyl coenzyme-A metabolism (PubMed:21530488). Does not show detectable activity towards fatty acid CoA thioesters (PubMed:21530488). {ECO:0000269|PubMed:21530488}.; FUNCTION: [Isoform 2]: Isoform 2 probably lacks enzyme activity. {ECO:0000269|PubMed:21530488}.; FUNCTION: [Isoform 3]: Isoform 3 probably lacks enzyme activity. {ECO:0000269|PubMed:21530488}.				2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; metal ion binding [GO:0046872]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; metal ion binding [GO:0046872]	
Q5SRR4	reviewed	LY65C_HUMAN	Lymphocyte antigen 6 complex locus protein G5c	LY6G5C C6orf20 G5C NG33	Homo sapiens (Human)	150	FUNCTION: May have a role in hematopoietic cell differentiation.			external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5SSG8	reviewed	MUC21_HUMAN	Mucin-21 (MUC-21) (Epiglycanin)	MUC21 C6orf205 UNQ697/PRO1342	Homo sapiens (Human)	566		MISCELLANEOUS: Could be considered as a marker for lung carcinomas.	negative regulation of cell-cell adhesion [GO:0022408]	Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]		Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; negative regulation of cell-cell adhesion [GO:0022408]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17977904}; Single-pass type I membrane protein {ECO:0000269|PubMed:17977904}; Extracellular side {ECO:0000269|PubMed:17977904}.
Q5SSJ5	reviewed	HP1B3_HUMAN	Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74)	HP1BP3	Homo sapiens (Human)	553	FUNCTION: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}.		cellular response to hypoxia [GO:0071456]; heterochromatin organization [GO:0070828]; nucleosome assembly [GO:0006334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of nucleus size [GO:0097298]	chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; nucleosome binding [GO:0031491]	chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; nucleosome binding [GO:0031491]; cellular response to hypoxia [GO:0071456]; heterochromatin organization [GO:0070828]; nucleosome assembly [GO:0006334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of nucleus size [GO:0097298]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24830416}. Chromosome {ECO:0000269|PubMed:20042602, ECO:0000269|PubMed:24830416}. Note=localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S). {ECO:0000269|PubMed:24830416}.
Q5ST30	reviewed	SYVM_HUMAN	Valine--tRNA ligase, mitochondrial (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) (Valyl-tRNA synthetase-like)	VARS2 KIAA1885 VARS2L VARSL	Homo sapiens (Human)	1063			valyl-tRNA aminoacylation [GO:0006438]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832]; valyl-tRNA aminoacylation [GO:0006438]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q5SVS4	reviewed	KMCP1_HUMAN	Kidney mitochondrial carrier protein 1 (Solute carrier family 25 member 30) (Uncoupling protein 6)	SLC25A30 KMCP1 UCP6	Homo sapiens (Human)	291	FUNCTION: Antiporter that transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate (PubMed:31356773). The sulfate/sulfate exchange is much higher than the phosphate/phosphate and malate/malate exchanges (PubMed:31356773). The transport affinities is higher for sulfate and thiosulfate than for any other substrate (PubMed:31356773). May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide (Probable). Also may mediate a very low unidirectional transport of sulfate, phosphate and (S)-malate (PubMed:31356773). {ECO:0000250, ECO:0000269|PubMed:31356773, ECO:0000305|PubMed:31356773}.		inorganic anion transport [GO:0015698]; mitochondrial transport [GO:0006839]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857]; inorganic anion transport [GO:0015698]; mitochondrial transport [GO:0006839]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9CR58}; Multi-pass membrane protein {ECO:0000255}.
Q5SW24	reviewed	DACT2_HUMAN	Dapper homolog 2 (Dapper antagonist of catenin 2)	DACT2 C6orf116 PP13671	Homo sapiens (Human)	774	FUNCTION: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity). {ECO:0000250}.		epithelial cell morphogenesis [GO:0003382]; hematopoietic progenitor cell differentiation [GO:0002244]; inner medullary collecting duct development [GO:0072061]; negative regulation of cell adhesion [GO:0007162]; negative regulation of nodal signaling pathway [GO:1900108]; skin development [GO:0043588]	cytoplasm [GO:0005737]	beta-catenin binding [GO:0008013]; delta-catenin binding [GO:0070097]; protein kinase A binding [GO:0051018]; protein kinase C binding [GO:0005080]; transcription factor binding [GO:0008134]	cytoplasm [GO:0005737]; beta-catenin binding [GO:0008013]; delta-catenin binding [GO:0070097]; protein kinase A binding [GO:0051018]; protein kinase C binding [GO:0005080]; transcription factor binding [GO:0008134]; epithelial cell morphogenesis [GO:0003382]; hematopoietic progenitor cell differentiation [GO:0002244]; inner medullary collecting duct development [GO:0072061]; negative regulation of cell adhesion [GO:0007162]; negative regulation of nodal signaling pathway [GO:1900108]; skin development [GO:0043588]	
Q5SW79	reviewed	CE170_HUMAN	Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)	CEP170 FAM68A KAB KIAA0470	Homo sapiens (Human)	1584	FUNCTION: Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.			centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; spindle [GO:0005819]		centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; spindle [GO:0005819]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:31789463}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15616186}. Note=Associated with the mature mother centriole. Associated with spindle microtubules during mitosis. Localizes to the distal appendage region of the centriole (PubMed:31789463). Localizes at the centriole proximal ends (PubMed:31789463). {ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:31789463}.
Q5SW96	reviewed	ARH_HUMAN	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein)	LDLRAP1 ARH	Homo sapiens (Human)	308	FUNCTION: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). {ECO:0000250|UniProtKB:D3ZAR1, ECO:0000269|PubMed:15728179}.		amyloid precursor protein metabolic process [GO:0042982]; cellular response to cytokine stimulus [GO:0071345]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; low-density lipoprotein particle clearance [GO:0034383]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of low-density lipoprotein particle clearance [GO:1905581]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905602]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; regulation of protein binding [GO:0043393]; regulation of protein localization to plasma membrane [GO:1903076]	axon [GO:0030424]; basal plasma membrane [GO:0009925]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; early endosome [GO:0005769]; neurofilament [GO:0005883]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	amyloid-beta binding [GO:0001540]; AP-1 adaptor complex binding [GO:0035650]; AP-2 adaptor complex binding [GO:0035612]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphotyrosine residue binding [GO:0001784]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159]	axon [GO:0030424]; basal plasma membrane [GO:0009925]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; early endosome [GO:0005769]; neurofilament [GO:0005883]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; amyloid-beta binding [GO:0001540]; AP-1 adaptor complex binding [GO:0035650]; AP-2 adaptor complex binding [GO:0035612]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphotyrosine residue binding [GO:0001784]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159]; amyloid precursor protein metabolic process [GO:0042982]; cellular response to cytokine stimulus [GO:0071345]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; low-density lipoprotein particle clearance [GO:0034383]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of low-density lipoprotein particle clearance [GO:1905581]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905602]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; regulation of protein binding [GO:0043393]; regulation of protein localization to plasma membrane [GO:1903076]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12451172}.
Q5SWA1	reviewed	PR15B_HUMAN	Protein phosphatase 1 regulatory subunit 15B	PPP1R15B	Homo sapiens (Human)	713	FUNCTION: Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. {ECO:0000269|PubMed:26159176, ECO:0000269|PubMed:26307080}.	MISCELLANEOUS: The phosphatase activity of the PPP1R15B-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.	ER overload response [GO:0006983]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-serine dephosphorylation [GO:0070262]; response to endoplasmic reticulum stress [GO:0034976]; response to hydrogen peroxide [GO:0042542]	endoplasmic reticulum [GO:0005783]; protein phosphatase type 1 complex [GO:0000164]	protein phosphatase regulator activity [GO:0019888]	endoplasmic reticulum [GO:0005783]; protein phosphatase type 1 complex [GO:0000164]; protein phosphatase regulator activity [GO:0019888]; ER overload response [GO:0006983]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-serine dephosphorylation [GO:0070262]; response to endoplasmic reticulum stress [GO:0034976]; response to hydrogen peroxide [GO:0042542]	
Q5SWW7	reviewed	CJ055_HUMAN	Uncharacterized protein C10orf55	C10orf55	Homo sapiens (Human)	151					identical protein binding [GO:0042802]	identical protein binding [GO:0042802]	
Q5SXH7	reviewed	PKHS1_HUMAN	Pleckstrin homology domain-containing family S member 1 (PH domain-containing family S member 1) (Epididymis luminal protein 185) (hEL185)	PLEKHS1 C10orf81	Homo sapiens (Human)	465							
Q5SXM2	reviewed	SNPC4_HUMAN	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit)	SNAPC4 SNAP190	Homo sapiens (Human)	1469	FUNCTION: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}.		snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; snRNA-activating protein complex [GO:0019185]	DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; snRNA-activating protein complex [GO:0019185]; DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Q5SY16	reviewed	NOL9_HUMAN	Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.-) (Nucleolar protein 9)	NOL9	Homo sapiens (Human)	702	FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA. {ECO:0000269|PubMed:21063389}.		cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000448]; maturation of 5.8S rRNA [GO:0000460]; phosphorylation [GO:0016310]	intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; polynucleotide 5'-hydroxyl-kinase activity [GO:0051731]; RNA binding [GO:0003723]	intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; polynucleotide 5'-hydroxyl-kinase activity [GO:0051731]; RNA binding [GO:0003723]; cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000448]; maturation of 5.8S rRNA [GO:0000460]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:21063389}. Note=Colocalizes with pre-60S rRNP particles.
Q5SYB0	reviewed	FRPD1_HUMAN	FERM and PDZ domain-containing protein 1 (FERM domain-containing protein 2)	FRMPD1 FRMD2 KIAA0967	Homo sapiens (Human)	1578	FUNCTION: Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1. {ECO:0000269|PubMed:18566450}.		establishment of protein localization to membrane [GO:0090150]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]		cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; establishment of protein localization to membrane [GO:0090150]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18566450}. Cell membrane {ECO:0000269|PubMed:18566450}; Peripheral membrane protein {ECO:0000269|PubMed:18566450}; Cytoplasmic side {ECO:0000269|PubMed:18566450}. Note=Found both in the cytoplasm and associated with the cell membrane. {ECO:0000269|PubMed:18566450}.
Q5SYC1	reviewed	CLVS2_HUMAN	Clavesin-2 (Retinaldehyde-binding protein 1-like 2) (clathrin vesicle-associated Sec14 protein 2)	CLVS2 C6orf212 C6orf213 RLBP1L2	Homo sapiens (Human)	327	FUNCTION: Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250, ECO:0000269|PubMed:19651769}.	MISCELLANEOUS: Binding to PtdIns(3,5)P2 is not required for localization. {ECO:0000250}.	lysosome organization [GO:0007040]	clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]	clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; lysosome organization [GO:0007040]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:19651769}; Peripheral membrane protein {ECO:0000269|PubMed:19651769}.
Q5SZK8	reviewed	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2 (ECM3 homolog)	FREM2	Homo sapiens (Human)	3169	FUNCTION: Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (PubMed:15838507). Required for epidermal adhesion (PubMed:15838507). Involved in the development of eyelids and the anterior segment of the eyeballs (PubMed:29688405, PubMed:30802441). {ECO:0000269|PubMed:15838507, ECO:0000269|PubMed:29688405, ECO:0000269|PubMed:30802441}.		anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell communication [GO:0007154]; embryonic digit morphogenesis [GO:0042733]; eye development [GO:0001654]; heart development [GO:0007507]; inner ear development [GO:0048839]; kidney development [GO:0001822]; morphogenesis of an epithelium [GO:0002009]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell communication [GO:0007154]; embryonic digit morphogenesis [GO:0042733]; eye development [GO:0001654]; heart development [GO:0007507]; inner ear development [GO:0048839]; kidney development [GO:0001822]; morphogenesis of an epithelium [GO:0002009]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:15838507}; Single-pass type I membrane protein {ECO:0000255}.
Q5SZL2	reviewed	CE85L_HUMAN	Centrosomal protein of 85 kDa-like (Serologically defined breast cancer antigen NY-BR-15)	CEP85L C6orf204	Homo sapiens (Human)	805	FUNCTION: Plays an essential role in neuronal cell migration. {ECO:0000269|PubMed:32097630}.		neuron migration [GO:0001764]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; pericentriolar material [GO:0000242]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; pericentriolar material [GO:0000242]; neuron migration [GO:0001764]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:32097630}. Note=Localized specifically to the pericentriolar region. {ECO:0000269|PubMed:32097630}.
Q5SZQ8	reviewed	CELF3_HUMAN	CUGBP Elav-like family member 3 (CELF-3) (Bruno-like protein 1) (CAG repeat protein 4) (CUG-BP- and ETR-3-like factor 3) (ELAV-type RNA-binding protein 1) (ETR-1) (Expanded repeat domain protein CAG/CTG 4) (RNA-binding protein BRUNOL-1) (Trinucleotide repeat-containing gene 4 protein)	CELF3 BRUNOL1 CAGH4 ERDA4 TNRC4	Homo sapiens (Human)	465	FUNCTION: RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:15009664}.		flagellated sperm motility [GO:0030317]; mRNA splice site recognition [GO:0006376]; ncRNA transcription [GO:0098781]; nuclear body organization [GO:0030575]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	7SK snRNA binding [GO:0097322]; mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; 7SK snRNA binding [GO:0097322]; mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; flagellated sperm motility [GO:0030317]; mRNA splice site recognition [GO:0006376]; ncRNA transcription [GO:0098781]; nuclear body organization [GO:0030575]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q5T011	reviewed	SZT2_HUMAN	KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog)	SZT2 C1orf84 KIAA0467	Homo sapiens (Human)	3432	FUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; central nervous system development [GO:0007417]; corpus callosum morphogenesis [GO:0021540]; negative regulation of TORC1 signaling [GO:1904262]; pigmentation [GO:0043473]; post-embryonic development [GO:0009791]; protein localization to lysosome [GO:0061462]; regulation of superoxide dismutase activity [GO:1901668]	KICSTOR complex [GO:0140007]; lysosomal membrane [GO:0005765]; peroxisome [GO:0005777]		KICSTOR complex [GO:0140007]; lysosomal membrane [GO:0005765]; peroxisome [GO:0005777]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; central nervous system development [GO:0007417]; corpus callosum morphogenesis [GO:0021540]; negative regulation of TORC1 signaling [GO:1904262]; pigmentation [GO:0043473]; post-embryonic development [GO:0009791]; protein localization to lysosome [GO:0061462]; regulation of superoxide dismutase activity [GO:1901668]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. Peroxisome {ECO:0000250|UniProtKB:A2A9C3}. Note=Localization to lysosomes is amino acid-independent. {ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}.
Q5T0F9	reviewed	C2D1B_HUMAN	Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2)	CC2D1B KIAA1836	Homo sapiens (Human)	858	FUNCTION: Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. {ECO:0000269|PubMed:19423080}.		regulation of transcription by RNA polymerase II [GO:0006357]	intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19423080}.
Q5T0J7	reviewed	TEX35_HUMAN	Testis-expressed protein 35	TEX35 C1orf49	Homo sapiens (Human)	233				microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]		microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]	
Q5T0N1	reviewed	CFA70_HUMAN	Cilia- and flagella-associated protein 70 (Tetratricopeptide repeat protein 18) (TPR repeat protein 18)	CFAP70 TTC18	Homo sapiens (Human)	1121	FUNCTION: Axoneme-binding protein that plays a role in the regulation of ciliary motility and cilium length. {ECO:0000250|UniProtKB:D3YVL2}.		cilium assembly [GO:0060271]; cilium movement [GO:0003341]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; extracellular exosome [GO:0070062]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126]		axoneme [GO:0005930]; ciliary basal body [GO:0036064]; extracellular exosome [GO:0070062]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:31621862}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000269|PubMed:31621862}. Cell projection, cilium {ECO:0000250|UniProtKB:D3YVL2}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:D3YVL2}. Note=Present all along the flagellum, with a marked signal at the base of the flagellum. {ECO:0000269|PubMed:31621862}.
Q5T0N5	reviewed	FBP1L_HUMAN	Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1)	FNBP1L C1orf39 TOCA1	Homo sapiens (Human)	605	FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}.		autophagy [GO:0006914]; cilium assembly [GO:0060271]; clathrin-dependent endocytosis [GO:0072583]; membrane invagination [GO:0010324]; plasma membrane tubulation [GO:0097320]; positive regulation of filopodium assembly [GO:0051491]; signal transduction [GO:0007165]; vesicle budding from membrane [GO:0006900]; vesicle organization [GO:0016050]; vesicle transport along actin filament [GO:0030050]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; GTPase binding [GO:0051020]; lipid binding [GO:0008289]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; GTPase binding [GO:0051020]; lipid binding [GO:0008289]; autophagy [GO:0006914]; cilium assembly [GO:0060271]; clathrin-dependent endocytosis [GO:0072583]; membrane invagination [GO:0010324]; plasma membrane tubulation [GO:0097320]; positive regulation of filopodium assembly [GO:0051491]; signal transduction [GO:0007165]; vesicle budding from membrane [GO:0006900]; vesicle organization [GO:0016050]; vesicle transport along actin filament [GO:0030050]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16757518}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Q5T0T0	reviewed	MARH8_HUMAN	E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178) (RING-type E3 ubiquitin transferase MARCHF8)	MARCHF8 MARCH8 MIR RNF178	Homo sapiens (Human)	291	FUNCTION: E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity (PubMed:34285233, PubMed:35019698, PubMed:35503863). Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies (PubMed:19117940, PubMed:19566897). Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins (PubMed:32934085). Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation (PubMed:35019698). Therefore, shows broad-spectrum inhibition against many viruses including retroviruses, rhabdoviruses, arenaviruses, sarbecoviruses or influenzaviruses (PubMed:35019698, PubMed:34285233). Strongly blocks human immunodeficiency virus type 1 envelope glycoprotein incorporation into virions by down-regulating its cell surface expression. Blocks also ebola virus glycoprotein/GP incorporation via surface down-regulation (PubMed:32934085). Mediates 'Lys-63'-linked polyubiquitination of influenza M2 to target it to lysosome for degradation (PubMed:34285233). Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway (PubMed:28320822). Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination (PubMed:34183449). Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity (PubMed:35503863). {ECO:0000269|PubMed:12582153, ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940, ECO:0000269|PubMed:19566897, ECO:0000269|PubMed:28320822, ECO:0000269|PubMed:32934085, ECO:0000269|PubMed:34183449, ECO:0000269|PubMed:34285233, ECO:0000269|PubMed:35019698, ECO:0000269|PubMed:35503863}.; FUNCTION: (Microbial infection) Mediates 'Lys-63'-linked polyubiquitination of hepatitis C virus/HCV protein NS2 which allows its binding to HGS, an ESCRT-0 complex component, and this interaction is essential for HCV envelopment. {ECO:0000269|PubMed:30759391}.		adaptive immune response [GO:0002250]; antigen processing and presentation of peptide antigen via MHC class II [GO:0002495]; immune response [GO:0006955]; protein polyubiquitination [GO:0000209]	cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]	MHC protein binding [GO:0042287]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; MHC protein binding [GO:0042287]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; adaptive immune response [GO:0002250]; antigen processing and presentation of peptide antigen via MHC class II [GO:0002495]; immune response [GO:0006955]; protein polyubiquitination [GO:0000209]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:32934085}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30759391, ECO:0000269|PubMed:35503863}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:19117940}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:35503863}; Multi-pass membrane protein {ECO:0000255}.
Q5T0W9	reviewed	FA83B_HUMAN	Protein FAM83B	FAM83B C6orf143	Homo sapiens (Human)	1011	FUNCTION: Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}.		cell population proliferation [GO:0008283]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; membrane [GO:0016020]	epidermal growth factor receptor binding [GO:0005154]; phosphatidylinositol 3-kinase catalytic subunit binding [GO:0036313]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; membrane [GO:0016020]; epidermal growth factor receptor binding [GO:0005154]; phosphatidylinositol 3-kinase catalytic subunit binding [GO:0036313]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein kinase binding [GO:0019901]; cell population proliferation [GO:0008283]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22886302}. Membrane {ECO:0000269|PubMed:22886302}.
Q5T124	reviewed	UBX11_HUMAN	UBX domain-containing protein 11 (Colorectal tumor-associated antigen COA-1) (Socius) (UBX domain-containing protein 5)	UBXN11 SOC UBXD5 PP2243	Homo sapiens (Human)	520	FUNCTION: May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity). {ECO:0000250}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]	ubiquitin binding [GO:0043130]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; ubiquitin binding [GO:0043130]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q5T160	reviewed	SYRM_HUMAN	Probable arginine--tRNA ligase, mitochondrial (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)	RARS2 RARSL	Homo sapiens (Human)	578			arginyl-tRNA aminoacylation [GO:0006420]; mitochondrial translation [GO:0032543]; tRNA aminoacylation for protein translation [GO:0006418]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; RNA binding [GO:0003723]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; RNA binding [GO:0003723]; arginyl-tRNA aminoacylation [GO:0006420]; mitochondrial translation [GO:0032543]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
Q5T197	reviewed	DCST1_HUMAN	E3 ubiquitin-protein ligase DCST1 (EC 2.3.2.27) (DC-STAMP domain-containing protein 1) (RING-type E3 ubiquitin transferase)	DCST1	Homo sapiens (Human)	706	FUNCTION: E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteasomal degradation thereby negatively regulating type-I-interferon signaling. Essential sperm cell-surface protein required for sperm-egg fusion and fertilization (By similarity). {ECO:0000250|UniProtKB:Q059Y8, ECO:0000269|PubMed:27782195}.		fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein ubiquitination [GO:0016567]; sperm-egg recognition [GO:0035036]; ubiquitin-dependent protein catabolic process [GO:0006511]	acrosomal membrane [GO:0002080]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	acrosomal membrane [GO:0002080]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein ubiquitination [GO:0016567]; sperm-egg recognition [GO:0035036]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27782195}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q059Y8}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in the anterior acrosome before the acrosome reaction and then translocates to the equatorial segment in acrosome-reacted sperm. {ECO:0000250|UniProtKB:Q059Y8}.
Q5T1B0	reviewed	AXDN1_HUMAN	Axonemal dynein light chain domain-containing protein 1	AXDND1 C1orf125	Homo sapiens (Human)	1012	FUNCTION: May be essential for spermiogenesis and male fertility probably by regulating the manchette dynamics, spermatid head shaping and sperm flagellum assembly. {ECO:0000250|UniProtKB:Q3UZ57}.		manchette assembly [GO:1905198]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; manchette assembly [GO:1905198]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34759295}.
Q5T1C6	reviewed	THEM4_HUMAN	Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4)	THEM4 CTMP	Homo sapiens (Human)	240	FUNCTION: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:17615157, ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19453107, ECO:0000269|PubMed:22871024}.		fatty acid metabolic process [GO:0006631]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; fatty acid metabolic process [GO:0006631]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11598301}. Cell projection, ruffle membrane {ECO:0000269|PubMed:11598301}. Cytoplasm {ECO:0000269|PubMed:19604401}. Mitochondrion {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19604401}. Mitochondrion inner membrane; Peripheral membrane protein {ECO:0000269|PubMed:19168129}. Mitochondrion intermembrane space {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19604401}. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. {ECO:0000269|PubMed:19168129}.
Q5T1H1	reviewed	EYS_HUMAN	Protein eyes shut homolog (Epidermal growth factor-like protein 10) (EGF-like protein 10) (Epidermal growth factor-like protein 11) (EGF-like protein 11) (Protein spacemaker homolog)	EYS C6orf178 C6orf179 C6orf180 EGFL10 EGFL11 SPAM UNQ9424/PRO34591	Homo sapiens (Human)	3165	FUNCTION: Required to maintain the integrity of photoreceptor cells (PubMed:18836446). Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (By similarity). {ECO:0000250|UniProtKB:B8JI71, ECO:0000269|PubMed:18836446}.	MISCELLANEOUS: Although the protein is conserved in Drosophila, the gene encoding the orthologous protein is inactive in rodents.	detection of light stimulus involved in visual perception [GO:0050908]; skeletal muscle tissue regeneration [GO:0043403]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; interphotoreceptor matrix [GO:0033165]; microtubule organizing center [GO:0005815]; photoreceptor outer segment [GO:0001750]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; interphotoreceptor matrix [GO:0033165]; microtubule organizing center [GO:0005815]; photoreceptor outer segment [GO:0001750]; calcium ion binding [GO:0005509]; detection of light stimulus involved in visual perception [GO:0050908]; skeletal muscle tissue regeneration [GO:0043403]	SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:27737822}. Cell projection, cilium {ECO:0000269|PubMed:27737822, ECO:0000269|PubMed:27846257}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:27846257}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27846257}. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix {ECO:0000269|PubMed:27737822}. Note=Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium (PubMed:27737822). Highly expressed in cone photoreceptor outer segments (PubMed:27737822). Weakly expressed in rod photoreceptor outer segments (By similarity). May localize to the cilium axoneme (PubMed:27846257). May also be secreted into the interphotoreceptor extracellular matrix (PubMed:27737822). {ECO:0000250|UniProtKB:A0A2K5V015, ECO:0000269|PubMed:27737822, ECO:0000269|PubMed:27846257}.
Q5T1M5	reviewed	FKB15_HUMAN	FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL)	FKBP15 KIAA0674	Homo sapiens (Human)	1219	FUNCTION: May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}.		endocytosis [GO:0006897]	actin cytoskeleton [GO:0015629]; early endosome [GO:0005769]; growth cone [GO:0030426]; membrane [GO:0016020]	actin binding [GO:0003779]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	actin cytoskeleton [GO:0015629]; early endosome [GO:0005769]; growth cone [GO:0030426]; membrane [GO:0016020]; actin binding [GO:0003779]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; endocytosis [GO:0006897]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6P9Q6}. Cell projection, axon {ECO:0000250|UniProtKB:Q6P9Q6}. Early endosome {ECO:0000269|PubMed:19121306}. Note=Present in axons and neuronal growth cones. {ECO:0000250|UniProtKB:Q6P9Q6}.
Q5T1R4	reviewed	ZEP3_HUMAN	Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3)	HIVEP3 KBP1 KIAA1555 KRC ZAS3	Homo sapiens (Human)	2406	FUNCTION: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}.		positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q5T1V6	reviewed	DDX59_HUMAN	Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5)	DDX59 ZNHIT5	Homo sapiens (Human)	619				cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23972372}. Nucleus {ECO:0000269|PubMed:23972372}. Note=Exhibits granular localization in the nucleus, as well as in the cytoplasm.
Q5T200	reviewed	ZC3HD_HUMAN	Zinc finger CCCH domain-containing protein 13	ZC3H13 KIAA0853	Homo sapiens (Human)	1668	FUNCTION: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.		mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; regulation of stem cell population maintenance [GO:2000036]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; regulation of stem cell population maintenance [GO:2000036]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:24100041}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24100041}.
Q5T230	reviewed	UTF1_HUMAN	Undifferentiated embryonic cell transcription factor 1	UTF1	Homo sapiens (Human)	341	FUNCTION: Acts as a transcriptional coactivator of ATF2. {ECO:0000269|PubMed:9748258}.		male gonad development [GO:0008584]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]	nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; male gonad development [GO:0008584]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5T280	reviewed	CI114_HUMAN	Putative methyltransferase C9orf114 (EC 2.1.1.-) (Centromere protein 32) (CENP-32) (Kinetochore-associated protein) (SPOUT domain-containing methyltransferase 1)	SPOUT1 C9orf114	Homo sapiens (Human)	376	FUNCTION: Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325). Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:20813266, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:28431233}.	MISCELLANEOUS: Depletion with RNAi causes a significant accumulation of cells in later prometaphase with misaligned chromosomes. {ECO:0000269|PubMed:20813266}.	cell cycle [GO:0007049]; cell division [GO:0051301]; maintenance of centrosome location [GO:0051661]; methylation [GO:0032259]; miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608]	cytoplasm [GO:0005737]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; spindle pole centrosome [GO:0031616]	methyltransferase activity [GO:0008168]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; spindle pole centrosome [GO:0031616]; methyltransferase activity [GO:0008168]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; cell cycle [GO:0007049]; cell division [GO:0051301]; maintenance of centrosome location [GO:0051661]; methylation [GO:0032259]; miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25657325}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266, ECO:0000269|PubMed:25657325}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25657325}. Note=Associated with the outer kinetochore. {ECO:0000269|PubMed:20813266}.
Q5T2D2	reviewed	TRML2_HUMAN	Trem-like transcript 2 protein (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2)	TREML2 C6orf76 TLT2 UNQ6268/PRO20473	Homo sapiens (Human)	321	FUNCTION: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. {ECO:0000269|PubMed:12645956, ECO:0000269|PubMed:18650384}.		T cell activation [GO:0042110]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q5T2D3	reviewed	OTUD3_HUMAN	OTU domain-containing protein 3 (EC 3.4.19.12)	OTUD3 KIAA0459	Homo sapiens (Human)	398	FUNCTION: Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (PubMed:23827681, PubMed:32011234, PubMed:35675826). Important regulator of energy metabolism (PubMed:35675826). Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation (PubMed:35675826). In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation (PubMed:35675826). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32011234, ECO:0000269|PubMed:35675826}.		cellular response to nutrient levels [GO:0031669]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; protein K11-linked deubiquitination [GO:0035871]; protein K27-linked deubiquitination [GO:1990167]; protein K48-linked deubiquitination [GO:0071108]; protein K6-linked deubiquitination [GO:0044313]; protein stabilization [GO:0050821]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cellular response to nutrient levels [GO:0031669]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; protein K11-linked deubiquitination [GO:0035871]; protein K27-linked deubiquitination [GO:1990167]; protein K48-linked deubiquitination [GO:0071108]; protein K6-linked deubiquitination [GO:0044313]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:35675826}. Nucleus {ECO:0000269|PubMed:35675826}. Note=Glucose or fatty acid promote nuclear translocation upon acetylation. {ECO:0000269|PubMed:35675826}.
Q5T2R2	reviewed	DPS1_HUMAN	All trans-polyprenyl-diphosphate synthase PDSS1 (All-trans-decaprenyl-diphosphate synthase subunit 1) (EC 2.5.1.91) (Decaprenyl pyrophosphate synthase subunit 1) (Decaprenyl-diphosphate synthase subunit 1) (Solanesyl-diphosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1)	PDSS1 DPS1 TPRT	Homo sapiens (Human)	415	FUNCTION: Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone (PubMed:16262699). Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively (PubMed:16262699). The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (PubMed:16262699). {ECO:0000269|PubMed:16262699}.		isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744]	mitochondrial matrix [GO:0005759]; transferase complex [GO:1990234]	all-trans-decaprenyl-diphosphate synthase activity [GO:0097269]; all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity [GO:0052923]; metal ion binding [GO:0046872]; prenyltransferase activity [GO:0004659]; protein heterodimerization activity [GO:0046982]; trans-hexaprenyltranstransferase activity [GO:0000010]	mitochondrial matrix [GO:0005759]; transferase complex [GO:1990234]; all-trans-decaprenyl-diphosphate synthase activity [GO:0097269]; all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity [GO:0052923]; metal ion binding [GO:0046872]; prenyltransferase activity [GO:0004659]; protein heterodimerization activity [GO:0046982]; trans-hexaprenyltranstransferase activity [GO:0000010]; isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q5T2S8	reviewed	ODAD2_HUMAN	Outer dynein arm-docking complex subunit 2 (Armadillo repeat-containing protein 4)	ODAD2 ARMC4	Homo sapiens (Human)	1044	FUNCTION: Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule (PubMed:27486780). Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (PubMed:23849778). {ECO:0000269|PubMed:23849778, ECO:0000269|PubMed:27486780}.		cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; outer dynein arm assembly [GO:0036158]; regulation of cilium beat frequency [GO:0003356]; ventricular system development [GO:0021591]	axoneme [GO:0005930]; ciliary base [GO:0097546]		axoneme [GO:0005930]; ciliary base [GO:0097546]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; outer dynein arm assembly [GO:0036158]; regulation of cilium beat frequency [GO:0003356]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23849778}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23849778}.
Q5T2T1	reviewed	MPP7_HUMAN	MAGUK p55 subfamily member 7	MPP7	Homo sapiens (Human)	576	FUNCTION: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. {ECO:0000269|PubMed:17332497}.		bicellular tight junction assembly [GO:0070830]; establishment of cell polarity [GO:0030010]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to adherens junction [GO:0071896]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; MPP7-DLG1-LIN7 complex [GO:0097025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; protein domain specific binding [GO:0019904]; signaling adaptor activity [GO:0035591]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; MPP7-DLG1-LIN7 complex [GO:0097025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; protein domain specific binding [GO:0019904]; signaling adaptor activity [GO:0035591]; bicellular tight junction assembly [GO:0070830]; establishment of cell polarity [GO:0030010]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to adherens junction [GO:0071896]	SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein {ECO:0000269|PubMed:17332497}. Lateral cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:17332497}. Cell junction, tight junction {ECO:0000269|PubMed:17237226, ECO:0000269|PubMed:17332497}. Cell junction, adherens junction {ECO:0000269|PubMed:17237226, ECO:0000269|PubMed:17332497}. Cytoplasm, cell cortex {ECO:0000269|PubMed:26481050}. Cytoplasm {ECO:0000269|PubMed:26481050}. Note=In epidermal cells, detected primarily at the lateral cell membrane. {ECO:0000269|PubMed:17332497}.
Q5T2W1	reviewed	NHRF3_HUMAN	Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)	PDZK1 CAP70 NHERF3 PDZD1	Homo sapiens (Human)	519	FUNCTION: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). {ECO:0000250}.		carnitine transport [GO:0015879]; positive regulation of cation transmembrane transport [GO:1904064]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of protein targeting to membrane [GO:0090314]; protein localization to plasma membrane [GO:0072659]; regulation of monoatomic anion transport [GO:0044070]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]; scavenger receptor binding [GO:0005124]; signaling receptor binding [GO:0005102]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]; scavenger receptor binding [GO:0005124]; signaling receptor binding [GO:0005102]; carnitine transport [GO:0015879]; positive regulation of cation transmembrane transport [GO:1904064]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of protein targeting to membrane [GO:0090314]; protein localization to plasma membrane [GO:0072659]; regulation of monoatomic anion transport [GO:0044070]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9JJ40}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ40}. Cell membrane {ECO:0000250|UniProtKB:Q9JIL4}. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes. {ECO:0000250|UniProtKB:Q9JJ40}.
Q5T3J3	reviewed	LRIF1_HUMAN	Ligand-dependent nuclear receptor-interacting factor 1 (HP1-binding protein enriched in inactive X chromosome protein 1) (HBiX1) (Receptor-interacting factor 1)	LRIF1 C1orf103 RIF1	Homo sapiens (Human)	769	FUNCTION: Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Also required for silencing of the DUX4 locus in somatic cells (PubMed:32467133). {ECO:0000269|PubMed:17455211, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:32467133}.		dosage compensation by inactivation of X chromosome [GO:0009048]; regulation of DNA-templated transcription [GO:0006355]	Barr body [GO:0001740]; centriolar satellite [GO:0034451]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]	nuclear retinoic acid receptor binding [GO:0042974]	Barr body [GO:0001740]; centriolar satellite [GO:0034451]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nuclear retinoic acid receptor binding [GO:0042974]; dosage compensation by inactivation of X chromosome [GO:0009048]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:23542155}. Nucleus matrix {ECO:0000269|PubMed:17455211}. Note=Localizes to Barr body; recruited by SMCHD1. {ECO:0000269|PubMed:23542155}.
Q5T3U5	reviewed	MRP7_HUMAN	ATP-binding cassette sub-family C member 10 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 7)	ABCC10 MRP7 SIMRP7	Homo sapiens (Human)	1492	FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:12527806, PubMed:15256465). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel (PubMed:15256465, PubMed:23087055). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP (PubMed:12527806). {ECO:0000269|PubMed:12527806, ECO:0000269|PubMed:15256465, ECO:0000269|PubMed:23087055, ECO:0000305|PubMed:35307651}.		leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; lipid transport [GO:0006869]; transmembrane transport [GO:0055085]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; lipid transport [GO:0006869]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12566991, ECO:0000269|PubMed:15256465}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12566991, ECO:0000269|PubMed:15256465}. Basolateral cell membrane {ECO:0000269|PubMed:23087055}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the basal membrane of Sertoli cells. {ECO:0000269|PubMed:35307651}.
Q5T440	reviewed	CAF17_HUMAN	Putative transferase CAF17, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog)	IBA57 C1orf69	Homo sapiens (Human)	356	FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. {ECO:0000269|PubMed:23462291}.		heme biosynthetic process [GO:0006783]; iron-sulfur cluster assembly [GO:0016226]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; transferase activity [GO:0016740]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; transferase activity [GO:0016740]; heme biosynthetic process [GO:0006783]; iron-sulfur cluster assembly [GO:0016226]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22323289, ECO:0000269|PubMed:23462291}.
Q5T442	reviewed	CXG2_HUMAN	Gap junction gamma-2 protein (Connexin-46.6) (Cx46.6) (Connexin-47) (Cx47) (Gap junction alpha-12 protein)	GJC2 GJA12	Homo sapiens (Human)	439	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. {ECO:0000269|PubMed:15192806}.		cell communication by electrical coupling [GO:0010644]; cell-cell signaling [GO:0007267]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; positive regulation of calcium ion transmembrane transport [GO:1904427]; positive regulation of gene expression [GO:0010628]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; regulation of protein phosphorylation [GO:0001932]; response to toxic substance [GO:0009636]	connexin complex [GO:0005922]; gap junction [GO:0005921]; myelin sheath [GO:0043209]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; proximal neuron projection [GO:1990769]	gap junction channel activity [GO:0005243]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763]	connexin complex [GO:0005922]; gap junction [GO:0005921]; myelin sheath [GO:0043209]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; proximal neuron projection [GO:1990769]; gap junction channel activity [GO:0005243]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763]; cell communication by electrical coupling [GO:0010644]; cell-cell signaling [GO:0007267]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; positive regulation of calcium ion transmembrane transport [GO:1904427]; positive regulation of gene expression [GO:0010628]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; regulation of protein phosphorylation [GO:0001932]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Q5T447	reviewed	HECD3_HUMAN	E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)	HECTD3	Homo sapiens (Human)	861	FUNCTION: E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). {ECO:0000250|UniProtKB:Q3U487, ECO:0000269|PubMed:18194665}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	perinuclear region of cytoplasm [GO:0048471]	syntaxin binding [GO:0019905]; ubiquitin-protein transferase activity [GO:0004842]	perinuclear region of cytoplasm [GO:0048471]; syntaxin binding [GO:0019905]; ubiquitin-protein transferase activity [GO:0004842]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
Q5T481	reviewed	RBM20_HUMAN	RNA-binding protein 20 (RNA-binding motif protein 20)	RBM20	Homo sapiens (Human)	1227	FUNCTION: RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:27531932, PubMed:27496873, PubMed:26604136, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:35427468, PubMed:34732726). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}.		heart formation [GO:0060914]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of RNA splicing [GO:0033120]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935]; zinc ion binding [GO:0008270]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935]; zinc ion binding [GO:0008270]; heart formation [GO:0060914]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of RNA splicing [GO:0033120]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00130, ECO:0000269|PubMed:23886709, ECO:0000269|PubMed:30262925, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:33188278, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:33188278, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. Note=The active form that regulates alternative splicing localizes to the nucleus (PubMed:35427468, PubMed:33188278, PubMed:34732726). Also localizes to cytoplasmic ribonucleoprotein granules; localization to cytoplasmic ribonucleoprotein granules plays an important regulatory role (PubMed:35427468, PubMed:33188278, PubMed:34732726). Subcellular localization is regulated by phosphorylation of different parts of the protein: while phosphorylation of the RS (arginine/serine-rich) region promotes nuclear localization, phosphorylation of the C-terminal disordered region promotes localization to cytoplasmic ribonucleoprotein granules (PubMed:35427468). {ECO:0000269|PubMed:33188278, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}.
Q5T4B2	reviewed	GT253_HUMAN	Inactive glycosyltransferase 25 family member 3 (Cerebral endothelial cell adhesion molecule)	CERCAM CEECAM1 GLT25D3 KIAA1502	Homo sapiens (Human)	595	FUNCTION: Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro. {ECO:0000269|PubMed:10608765, ECO:0000269|PubMed:19075007}.		cell adhesion [GO:0007155]; leukocyte cell-cell adhesion [GO:0007159]	endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; cell adhesion [GO:0007155]; leukocyte cell-cell adhesion [GO:0007159]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q5T4D3	reviewed	TMTC4_HUMAN	Protein O-mannosyl-transferase TMTC4 (EC 2.4.1.109) (Transmembrane and TPR repeat-containing protein 4)	TMTC4	Homo sapiens (Human)	741	FUNCTION: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. {ECO:0000269|PubMed:28973932}.		endoplasmic reticulum unfolded protein response [GO:0030968]; outer hair cell apoptotic process [GO:1905584]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; protein O-linked mannosylation [GO:0035269]; sensory perception of sound [GO:0007605]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	ATPase binding [GO:0051117]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; ATPase binding [GO:0051117]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]; endoplasmic reticulum unfolded protein response [GO:0030968]; outer hair cell apoptotic process [GO:1905584]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; protein O-linked mannosylation [GO:0035269]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000305}.
Q5T4F4	reviewed	ZFY27_HUMAN	Protrudin (Spastic paraplegia 33 protein) (Zinc finger FYVE domain-containing protein 27)	ZFYVE27 SPG33	Homo sapiens (Human)	411	FUNCTION: Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701). {ECO:0000250|UniProtKB:Q3TXX3, ECO:0000269|PubMed:17082457, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:21976701, ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:24668814}.		endoplasmic reticulum tubular network formation [GO:0071787]; neuron projection development [GO:0031175]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of axon extension [GO:0045773]; protein localization to plasma membrane [GO:0072659]; vesicle-mediated transport [GO:0016192]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; growth cone membrane [GO:0032584]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; recycling endosome membrane [GO:0055038]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein self-association [GO:0043621]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; growth cone membrane [GO:0032584]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; recycling endosome membrane [GO:0055038]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein self-association [GO:0043621]; endoplasmic reticulum tubular network formation [GO:0071787]; neuron projection development [GO:0031175]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of axon extension [GO:0045773]; protein localization to plasma membrane [GO:0072659]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:Q6P7B7}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:24668814}; Multi-pass membrane protein {ECO:0000269|PubMed:23969831}. Cell projection, growth cone membrane {ECO:0000250|UniProtKB:Q3TXX3}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes at both dendrites and axons (By similarity). Localizes to endoplasmic reticulum tubular network. {ECO:0000250|UniProtKB:Q3TXX3, ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:24668814}.
Q5T4F7	reviewed	SFRP5_HUMAN	Secreted frizzled-related protein 5 (sFRP-5) (Frizzled-related protein 1b) (FRP-1b) (Secreted apoptosis-related protein 3) (SARP-3)	SFRP5 FRP1B SARP3	Homo sapiens (Human)	317	FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.		anatomical structure morphogenesis [GO:0009653]; apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; establishment or maintenance of cell polarity [GO:0007163]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of Wnt signaling pathway [GO:0030178]; negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis [GO:2000057]; non-canonical Wnt signaling pathway [GO:0035567]; signal transduction [GO:0007165]; visual perception [GO:0007601]	extracellular space [GO:0005615]	Wnt-protein binding [GO:0017147]	extracellular space [GO:0005615]; Wnt-protein binding [GO:0017147]; anatomical structure morphogenesis [GO:0009653]; apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; establishment or maintenance of cell polarity [GO:0007163]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of Wnt signaling pathway [GO:0030178]; negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis [GO:2000057]; non-canonical Wnt signaling pathway [GO:0035567]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q5T4S7	reviewed	UBR4_HUMAN	E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (N-recognin-4) (RING-type E3 ubiquitin transferase UBR4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) (p600) (Zinc finger UBR1-type protein 1)	UBR4 KIAA0462 KIAA1307 RBAF600 ZUBR1	Homo sapiens (Human)	5183	FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781}.		negative regulation of fatty acid biosynthetic process [GO:0045717]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	centrosome [GO:0005813]; cytosol [GO:0005829]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	calmodulin binding [GO:0005516]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytosol [GO:0005829]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; calmodulin binding [GO:0005516]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; negative regulation of fatty acid biosynthetic process [GO:0045717]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.
Q5T4W7	reviewed	ARTN_HUMAN	Artemin (Enovin) (Neublastin)	ARTN EVN	Homo sapiens (Human)	220	FUNCTION: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. {ECO:0000269|PubMed:10583383, ECO:0000269|PubMed:9883723}.		axon guidance [GO:0007411]; induction of positive chemotaxis [GO:0050930]; lymphocyte migration into lymphoid organs [GO:0097021]; neuroblast proliferation [GO:0007405]; peripheral nervous system development [GO:0007422]; Peyer's patch morphogenesis [GO:0061146]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; axon guidance [GO:0007411]; induction of positive chemotaxis [GO:0050930]; lymphocyte migration into lymphoid organs [GO:0097021]; neuroblast proliferation [GO:0007405]; peripheral nervous system development [GO:0007422]; Peyer's patch morphogenesis [GO:0061146]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q5T5A8	reviewed	LCE3C_HUMAN	Late cornified envelope protein 3C (Late envelope protein 15) (Small proline-rich-like epidermal differentiation complex protein 3A)	LCE3C LEP15 SPRL3A	Homo sapiens (Human)	94	FUNCTION: A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035). {ECO:0000269|PubMed:28634035, ECO:0000305|PubMed:28634035}.		defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; keratinization [GO:0031424]; killing of cells of another organism [GO:0031640]			defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; keratinization [GO:0031424]; killing of cells of another organism [GO:0031640]	
Q5T5B0	reviewed	LCE3E_HUMAN	Late cornified envelope protein 3E (Late envelope protein 17)	LCE3E LEP17	Homo sapiens (Human)	92	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]			keratinization [GO:0031424]	
Q5T5C0	reviewed	STXB5_HUMAN	Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1)	STXBP5 LLGL3	Homo sapiens (Human)	1151	FUNCTION: Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}.		exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of protein secretion [GO:0050708]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle priming [GO:0010807]	acetylcholine-gated channel complex [GO:0005892]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of neuronal dense core vesicle membrane [GO:0098674]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]	GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]	acetylcholine-gated channel complex [GO:0005892]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of neuronal dense core vesicle membrane [GO:0098674]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]; exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of protein secretion [GO:0050708]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle priming [GO:0010807]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Synapse {ECO:0000250}. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles (By similarity). {ECO:0000250}.
Q5T5P2	reviewed	SKT_HUMAN	Sickle tail protein homolog	KIAA1217 SKT	Homo sapiens (Human)	1943	FUNCTION: Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.		embryonic skeletal system development [GO:0048706]	centrosome [GO:0005813]; cytoplasm [GO:0005737]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; embryonic skeletal system development [GO:0048706]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26638075}. Cytoplasm {ECO:0000250|UniProtKB:A2AQ25}.
Q5T5U3	reviewed	RHG21_HUMAN	Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)	ARHGAP21 ARHGAP10 KIAA1424	Homo sapiens (Human)	1958	FUNCTION: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169}.	MISCELLANEOUS: Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers.; MISCELLANEOUS: Required for In1A-dependent entry of Listeria monocytogenes into cells.	establishment of Golgi localization [GO:0051683]; Golgi localization [GO:0051645]; Golgi organization [GO:0007030]; maintenance of Golgi location [GO:0051684]; organelle transport along microtubule [GO:0072384]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	actin cytoskeleton [GO:0015629]; anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	actin cytoskeleton [GO:0015629]; anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; establishment of Golgi localization [GO:0051683]; Golgi localization [GO:0051645]; Golgi organization [GO:0007030]; maintenance of Golgi location [GO:0051684]; organelle transport along microtubule [GO:0072384]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1.
Q5T5X7	reviewed	BEND3_HUMAN	BEN domain-containing protein 3	BEND3 KIAA1553	Homo sapiens (Human)	828	FUNCTION: Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}.		DNA methylation [GO:0006306]; negative regulation of transcription by RNA polymerase I [GO:0016479]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP metabolic process [GO:1903580]; protein homooligomerization [GO:0051260]; rDNA heterochromatin formation [GO:0000183]	heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	rDNA binding [GO:0000182]	heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; rDNA binding [GO:0000182]; DNA methylation [GO:0006306]; negative regulation of transcription by RNA polymerase I [GO:0016479]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP metabolic process [GO:1903580]; protein homooligomerization [GO:0051260]; rDNA heterochromatin formation [GO:0000183]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:25600804}. Nucleus, nucleolus {ECO:0000269|PubMed:26100909}. Note=In the nucleus, observed in heterochromatic foci containing CBX1, CBX3, CBX5 and histone H3 trimethylated at 'Lys-9'. Released from chromatin during decondensation. Association with heterochromatin does not depend on sumoylation. {ECO:0000269|PubMed:21914818}.
Q5T5Y3	reviewed	CAMP1_HUMAN	Calmodulin-regulated spectrin-associated protein 1	CAMSAP1	Homo sapiens (Human)	1602	FUNCTION: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24486153, PubMed:24706919, PubMed:24117850). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}.		cytoskeleton organization [GO:0007010]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; regulation of cell morphogenesis [GO:0022604]; regulation of microtubule polymerization [GO:0031113]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]	calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507]; cytoskeleton organization [GO:0007010]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; regulation of cell morphogenesis [GO:0022604]; regulation of microtubule polymerization [GO:0031113]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19508979}. Note=Associates with the minus-end of microtubules (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, does not form stretches of decorated microtubule minus-ends (PubMed:24486153, PubMed:24706919). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}.
Q5T601	reviewed	AGRF1_HUMAN	Adhesion G-protein coupled receptor F1 (G protein-coupled receptor 110) (G protein-coupled receptor KPG_012) (G protein-coupled receptor PGR19)	ADGRF1 GPR110 PGR19	Homo sapiens (Human)	910	FUNCTION: Orphan receptor.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; energy reserve metabolic process [GO:0006112]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; memory [GO:0007613]; neuron projection development [GO:0031175]; regulation of lipid metabolic process [GO:0019216]; synapse assembly [GO:0007416]	cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cannabinoid receptor activity [GO:0004949]; G protein-coupled receptor activity [GO:0004930]	cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cannabinoid receptor activity [GO:0004949]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; energy reserve metabolic process [GO:0006112]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; memory [GO:0007613]; neuron projection development [GO:0031175]; regulation of lipid metabolic process [GO:0019216]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20149256}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:20149256}.
Q5T619	reviewed	ZN648_HUMAN	Zinc finger protein 648	ZNF648	Homo sapiens (Human)	568	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5T655	reviewed	CFA58_HUMAN	Cilia- and flagella-associated protein 58 (Coiled-coil domain-containing protein 147)	CFAP58 C10orf80 CCDC147	Homo sapiens (Human)	872	FUNCTION: Has an essential role in the assembly and organization of the sperm flagellar axoneme (PubMed:32791035). Required for the elongation of the primary cilium and sperm flagellar midpiece via modulation of the Notch signaling pathway (By similarity). {ECO:0000250|UniProtKB:B2RW38, ECO:0000269|PubMed:32791035}.		cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; Notch signaling pathway [GO:0007219]; protein localization to motile cilium [GO:0120229]; sperm axoneme assembly [GO:0007288]; sperm flagellum assembly [GO:0120316]; sperm mitochondrial sheath assembly [GO:0120317]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; Notch signaling pathway [GO:0007219]; protein localization to motile cilium [GO:0120229]; sperm axoneme assembly [GO:0007288]; sperm flagellum assembly [GO:0120316]; sperm mitochondrial sheath assembly [GO:0120317]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:A8HUA1}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:32791035, ECO:0000269|PubMed:33314088}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:B2RW38}. Note=Localized to the entire flagellum and predominantly concentrated in the midpiece. Co-localizes with ODFP2 at the centrosome (By similarity). {ECO:0000250|UniProtKB:B2RW38, ECO:0000269|PubMed:32791035}.
Q5T686	reviewed	AVPI1_HUMAN	Arginine vasopressin-induced protein 1 (AVP-induced protein 1)	AVPI1 NPD013 PP5395	Homo sapiens (Human)	147	FUNCTION: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling. {ECO:0000250}.		cell cycle [GO:0007049]; positive regulation of MAPK cascade [GO:0043410]			cell cycle [GO:0007049]; positive regulation of MAPK cascade [GO:0043410]	
Q5T6F0	reviewed	DCA12_HUMAN	DDB1- and CUL4-associated factor 12 (Centrosome-related protein TCC52) (Testis cancer centrosome-related protein) (WD repeat-containing protein 40A)	DCAF12 KIAA1892 TCC52 WDR40A	Homo sapiens (Human)	453	FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:16949367, PubMed:16964240, PubMed:29779948). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948). The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:31267705). Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy (PubMed:31267705). Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins such as MOV10, leading to their ubiquitination and degradation. Controls the protein level of MOV10 during spermatogenesis and in T cells, especially after their activation (PubMed:34065512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:31267705, ECO:0000269|PubMed:34065512}.		protein ubiquitination [GO:0016567]; regulation of autophagy [GO:0010506]; T cell activation [GO:0042110]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	centrosome [GO:0005813]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	centrosome [GO:0005813]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; protein ubiquitination [GO:0016567]; regulation of autophagy [GO:0010506]; T cell activation [GO:0042110]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18957058, ECO:0000269|PubMed:34065512}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18957058}. Nucleus {ECO:0000269|PubMed:34065512}.
Q5T6F2	reviewed	UBAP2_HUMAN	Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2)	UBAP2 KIAA1491	Homo sapiens (Human)	1119	FUNCTION: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}.		regulation of gene expression [GO:0010468]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35633597}. Chromosome {ECO:0000269|PubMed:35633597}. Cytoplasm {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. Note=Associates with nuclear chromatin. {ECO:0000269|PubMed:35633597}.
Q5T6S3	reviewed	PHF19_HUMAN	PHD finger protein 19 (Polycomb-like protein 3) (hPCL3)	PHF19 PCL3	Homo sapiens (Human)	580	FUNCTION: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:23104054, PubMed:31959557). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832). {ECO:0000269|PubMed:15563832, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:23273982, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.	MISCELLANEOUS: Down-regulated in spheroid melanoma cells that display an invasive phenotype, characterized by a higher motility, a poor proliferation rate and a gain of pluripotency gene expression. PHF19 favors the proliferation and reduces the transmigration capacity of melanoma cell lines, 2 properties of invasive cells, suggesting that down-regulation may participate in the switch from proliferative to invasive states in melanoma cells (PubMed:22487681). {ECO:0000305|PubMed:22487681}.	chromatin organization [GO:0006325]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]	ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]	ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; chromatin organization [GO:0006325]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15563832, ECO:0000269|PubMed:31959557}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:31959557}.
Q5T6X5	reviewed	GPC6A_HUMAN	G-protein coupled receptor family C group 6 member A (hGPRC6A) (G-protein coupled receptor GPCR33) (hGPCR33)	GPRC6A	Homo sapiens (Human)	926	FUNCTION: Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations (PubMed:15576628). Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids (PubMed:15576628). The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+) (By similarity). Seems to act through a G(q)/G(11) and G(i)-coupled pathway (By similarity). Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (By similarity). Mediates the non-genomic effects of androgens in multiple tissue (By similarity). May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (PubMed:20947496). {ECO:0000250|UniProtKB:Q8K4Z6, ECO:0000269|PubMed:15576628, ECO:0000269|PubMed:20947496}.	MISCELLANEOUS: [Isoform 1]: Major isoform.	regulation of testosterone biosynthetic process [GO:2000224]; response to amino acid [GO:0043200]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; regulation of testosterone biosynthetic process [GO:2000224]; response to amino acid [GO:0043200]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8K4Z6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K4Z6}.
Q5T700	reviewed	LRAD1_HUMAN	Low-density lipoprotein receptor class A domain-containing protein 1	LDLRAD1	Homo sapiens (Human)	205				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5T749	reviewed	KPRP_HUMAN	Keratinocyte proline-rich protein (hKPRP)	KPRP C1orf45	Homo sapiens (Human)	579				cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]		cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q5T751	reviewed	LCE1C_HUMAN	Late cornified envelope protein 1C (Late envelope protein 3)	LCE1C LEP3	Homo sapiens (Human)	118	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]			keratinization [GO:0031424]	
Q5T752	reviewed	LCE1D_HUMAN	Late cornified envelope protein 1D (Late envelope protein 4)	LCE1D LEP4	Homo sapiens (Human)	114	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	cellular response to calcium ion [GO:0071277]; cognition [GO:0050890]; keratinization [GO:0031424]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]	identical protein binding [GO:0042802]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; identical protein binding [GO:0042802]; cellular response to calcium ion [GO:0071277]; cognition [GO:0050890]; keratinization [GO:0031424]	
Q5T753	reviewed	LCE1E_HUMAN	Late cornified envelope protein 1E (Late envelope protein 5)	LCE1E LEP5	Homo sapiens (Human)	118	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]		identical protein binding [GO:0042802]	identical protein binding [GO:0042802]; keratinization [GO:0031424]	
Q5T754	reviewed	LCE1F_HUMAN	Late cornified envelope protein 1F (Late envelope protein 6)	LCE1F LEP6	Homo sapiens (Human)	118	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]		identical protein binding [GO:0042802]	identical protein binding [GO:0042802]; keratinization [GO:0031424]	
Q5T7B8	reviewed	KIF24_HUMAN	Kinesin-like protein KIF24	KIF24 C9orf48	Homo sapiens (Human)	1368	FUNCTION: Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}.		cilium assembly [GO:0060271]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; negative regulation of cilium assembly [GO:1902018]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; cilium assembly [GO:0060271]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; negative regulation of cilium assembly [GO:1902018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:30375385}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30375385}. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.
Q5T7M4	reviewed	ADIPL_HUMAN	Adipolin (Adipose-derived insulin-sensitizing factor) (C1q and TNF related protein 12) (Complement C1q tumor necrosis factor-related protein 12) [Cleaved into: Adipolin fC1QTNF12 (Adipolin fCTRP12) (Adipolin full-length form); Adipolin gC1QTNF12 (Adipolin cleaved form) (Adipolin gCTRP12)]	C1QTNF12 C1QDC2 CTRP12 FAM132A	Homo sapiens (Human)	302	FUNCTION: Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. {ECO:0000250|UniProtKB:Q8R2Z0}.		establishment of localization in cell [GO:0051649]; gluconeogenesis [GO:0006094]; glucose import [GO:0046323]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of glucose import [GO:0046326]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of glucose import [GO:0046324]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	hormone activity [GO:0005179]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; establishment of localization in cell [GO:0051649]; gluconeogenesis [GO:0006094]; glucose import [GO:0046323]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of glucose import [GO:0046326]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of glucose import [GO:0046324]	SUBCELLULAR LOCATION: [Adipolin fC1QTNF12]: Secreted {ECO:0000269|PubMed:22275362}.; SUBCELLULAR LOCATION: [Adipolin gC1QTNF12]: Secreted {ECO:0000269|PubMed:22275362}. Note=In sera is the predominant form. {ECO:0000269|PubMed:22275362}.
Q5T7N3	reviewed	KANK4_HUMAN	KN motif and ankyrin repeat domain-containing protein 4 (Ankyrin repeat domain-containing protein 38)	KANK4 ANKRD38	Homo sapiens (Human)	995	FUNCTION: May be involved in the control of cytoskeleton formation by regulating actin polymerization. {ECO:0000269|PubMed:17996375}.		negative regulation of actin filament polymerization [GO:0030837]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; negative regulation of actin filament polymerization [GO:0030837]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:25961457}.
Q5T7P2	reviewed	LCE1A_HUMAN	Late cornified envelope protein 1A (Late envelope protein 1)	LCE1A LEP1	Homo sapiens (Human)	110	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]	cytosol [GO:0005829]		cytosol [GO:0005829]; keratinization [GO:0031424]	
Q5T7P3	reviewed	LCE1B_HUMAN	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A)	LCE1B LEP2 SPRL2A	Homo sapiens (Human)	118	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]		identical protein binding [GO:0042802]	identical protein binding [GO:0042802]; keratinization [GO:0031424]	
Q5T7P8	reviewed	SYT6_HUMAN	Synaptotagmin-6 (Synaptotagmin VI) (SytVI)	SYT6	Homo sapiens (Human)	510	FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity). {ECO:0000250|UniProtKB:Q9R0N8}.		acrosomal vesicle exocytosis [GO:0060478]; calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; membrane [GO:0016020]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; membrane [GO:0016020]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905]; acrosomal vesicle exocytosis [GO:0060478]; calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9R0N8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N8}.; SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000250|UniProtKB:Q9R0N8}; Single-pass membrane protein {ECO:0000250}. Note=Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment (By similarity). {ECO:0000250|UniProtKB:Q9R0N8}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9R0N8}. Cell membrane {ECO:0000250|UniProtKB:Q9R0N8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9R0N8}.
Q5T7V8	reviewed	GORAB_HUMAN	RAB6-interacting golgin (N-terminal kinase-like-binding protein 1) (NTKL-BP1) (NTKL-binding protein 1) (hNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-BP1) (SCYL1-binding protein 1)	GORAB NTKLBP1 SCYL1BP1	Homo sapiens (Human)	369			hair follicle morphogenesis [GO:0031069]; non-motile cilium assembly [GO:1905515]; positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901622]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; hair follicle morphogenesis [GO:0031069]; non-motile cilium assembly [GO:1905515]; positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901622]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15781263}. Golgi apparatus {ECO:0000269|PubMed:18997784}.
Q5T7W0	reviewed	ZN618_HUMAN	Zinc finger protein 618	ZNF618 KIAA1952	Homo sapiens (Human)	954	FUNCTION: Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization. {ECO:0000269|PubMed:27129234}.		positive regulation of chromatin binding [GO:0035563]	chromatin [GO:0000785]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; transcription coregulator binding [GO:0001221]	chromatin [GO:0000785]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; transcription coregulator binding [GO:0001221]; positive regulation of chromatin binding [GO:0035563]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27129234}. Chromosome {ECO:0000269|PubMed:27129234}. Note=Localizes at genomic loci that are enriched for 5-hydroxymethylcytosine (5hmC). {ECO:0000269|PubMed:27129234}.
Q5T7W7	reviewed	TSTD2_HUMAN	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (Rhodanese domain-containing protein 2)	TSTD2 C9orf97 PP4189	Homo sapiens (Human)	516							
Q5T848	reviewed	MGLYR_HUMAN	Metabotropic glycine receptor (mGlyR) (G-protein coupled receptor 158)	GPR158 KIAA1136	Homo sapiens (Human)	1215	FUNCTION: Metabotropic receptor for glycine that controls synapse formation and function in the brain (PubMed:36996198). Acts as an atypical G-protein coupled receptor that recruits and regulates the RGS7-GNB5 complex instead of activating G proteins (PubMed:31189666, PubMed:36996198). In absence of glycine ligand, promotes the GTPase activator activity of RGS7, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:36996198). Glycine-binding changes the conformation of the intracellular surface, inhibiting the GTPase activator activity of the RGS7-GNB5 complex, promoting G protein alpha subunits into their active GTP-bound form and regulating cAMP levels (PubMed:36996198). Also able to bind taurine, a compound closely related to glycine, but with a two-fold lower affinity (PubMed:36996198). Glycine receptor-dependent regulation of cAMP controls key ion channels, kinases and neurotrophic factors involved in neuronal excitability and synaptic transmission (PubMed:36996198). Plays a pivotal role in regulating mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Also involved in spatial learning by regulating hippocampal CA1 neuronal excitability (By similarity). Acts as a synaptic organizer in the hippocampus, required for proper mossy fiber-CA3 neurocircuitry establishment, structure and function: induces presynaptic differentiation in contacting axons via its interaction with GPC4 (By similarity). In addition to glycine, may also act as a receptor for osteocalcin (BGLAP) hormone: osteocalcin-binding initiates a signaling response that prevents neuronal apoptosis in the hippocampus and regulates the synthesis of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q8C419, ECO:0000269|PubMed:31189666, ECO:0000269|PubMed:36996198}.		brain development [GO:0007420]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of neurotransmitter secretion [GO:0001956]; protein localization to plasma membrane [GO:0072659]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synapse organization [GO:0050807]	cell projection [GO:0042995]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	enzyme activator activity [GO:0008047]; G protein-coupled receptor activity [GO:0004930]; metabotropic glycine receptor activity [GO:0160079]; transmembrane signaling receptor activity [GO:0004888]	cell projection [GO:0042995]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; enzyme activator activity [GO:0008047]; G protein-coupled receptor activity [GO:0004930]; metabotropic glycine receptor activity [GO:0160079]; transmembrane signaling receptor activity [GO:0004888]; brain development [GO:0007420]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of neurotransmitter secretion [GO:0001956]; protein localization to plasma membrane [GO:0072659]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synapse organization [GO:0050807]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23451275, ECO:0000269|PubMed:30855200, ECO:0000269|PubMed:31189666}; Multi-pass membrane protein {ECO:0000269|PubMed:34793198, ECO:0000269|PubMed:34815401}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q8C419}; Multi-pass membrane protein {ECO:0000269|PubMed:34793198, ECO:0000269|PubMed:34815401}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q8C419}; Multi-pass membrane protein {ECO:0000269|PubMed:34793198, ECO:0000269|PubMed:34815401}. Nucleus {ECO:0000269|PubMed:23451275, ECO:0000269|PubMed:30855200}. Note=Mainly localizes to the postsynaptic membrane, with a small portion to the presynaptic membrane (By similarity). Trafficks between the nucleus and the cell membrane; it is unclear how a multi-pass membrane protein can traffick between the nucleus and the cell membrane (PubMed:23451275). {ECO:0000250|UniProtKB:Q8C419, ECO:0000269|PubMed:23451275}.
Q5T890	reviewed	ER6L2_HUMAN	DNA excision repair protein ERCC-6-like 2 (EC 3.6.4.-) (DNA repair and recombination protein RAD26-like)	ERCC6L2 C9orf102 RAD26L	Homo sapiens (Human)	1561	FUNCTION: May be involved in early DNA damage response. {ECO:0000269|PubMed:24507776}.		cellular response to reactive oxygen species [GO:0034614]; interstrand cross-link repair [GO:0036297]	cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; protein kinase binding [GO:0019901]; cellular response to reactive oxygen species [GO:0034614]; interstrand cross-link repair [GO:0036297]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mitochondrion. Note=Colocalizes with NEK6 in the centrosome. In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (ROS)-dependent manner.
Q5T8A7	reviewed	PPR26_HUMAN	Protein phosphatase 1 regulatory subunit 26	PPP1R26 KIAA0649	Homo sapiens (Human)	1209	FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation. {ECO:0000269|PubMed:16053918, ECO:0000269|PubMed:19389623}.			nucleolus [GO:0005730]	protein phosphatase inhibitor activity [GO:0004864]	nucleolus [GO:0005730]; protein phosphatase inhibitor activity [GO:0004864]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16053918}.
Q5T8D3	reviewed	ACBD5_HUMAN	Acyl-CoA-binding domain-containing protein 5	ACBD5 KIAA1996	Homo sapiens (Human)	534	FUNCTION: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. {ECO:0000269|PubMed:24535825}.		autophagy of peroxisome [GO:0030242]; fatty acid metabolic process [GO:0006631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	fatty-acyl-CoA binding [GO:0000062]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; fatty-acyl-CoA binding [GO:0000062]; autophagy of peroxisome [GO:0030242]; fatty acid metabolic process [GO:0006631]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q5T8I9	reviewed	HENMT_HUMAN	Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (HEN1 methyltransferase homolog 1)	HENMT1 C1orf59	Homo sapiens (Human)	393	FUNCTION: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. {ECO:0000250|UniProtKB:Q8CAE2}.		piRNA processing [GO:0034587]; RNA methylation [GO:0001510]; siRNA processing [GO:0030422]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P granule [GO:0043186]	metal ion binding [GO:0046872]; O-methyltransferase activity [GO:0008171]; RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; small RNA 2'-O-methyltransferase activity [GO:0090486]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P granule [GO:0043186]; metal ion binding [GO:0046872]; O-methyltransferase activity [GO:0008171]; RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; small RNA 2'-O-methyltransferase activity [GO:0090486]; piRNA processing [GO:0034587]; RNA methylation [GO:0001510]; siRNA processing [GO:0030422]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q568P9}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q568P9}.
Q5T9A4	reviewed	ATD3B_HUMAN	ATPase family AAA domain-containing protein 3B (AAA-TOB3)	ATAD3B KIAA1273 TOB3	Homo sapiens (Human)	648	FUNCTION: May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes. {ECO:0000269|PubMed:22664726}.		mitochondrion organization [GO:0007005]	ficolin-1-rich granule membrane [GO:0101003]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	ficolin-1-rich granule membrane [GO:0101003]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; mitochondrion organization [GO:0007005]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16909202, ECO:0000269|PubMed:18063578}; Peripheral membrane protein {ECO:0000269|PubMed:16909202, ECO:0000269|PubMed:18063578}. Note=Has been found to co-purify with nucleoids (PubMed:22453275). Since it does not face the mitochondrial matrix, the association with nucleoids could be mediated by ATAD3A. {ECO:0000269|PubMed:22453275}.
Q5T9C2	reviewed	EEIG1_HUMAN	Early estrogen-induced gene 1 protein (EEIG1)	EEIG1 C9orf132 FAM102A	Homo sapiens (Human)	384	FUNCTION: Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}.			cytoplasm [GO:0005737]; membrane raft [GO:0045121]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; membrane raft [GO:0045121]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q78T81}. Cytoplasm {ECO:0000250|UniProtKB:Q78T81}. Membrane raft {ECO:0000250|UniProtKB:Q78T81}.
Q5T9C9	reviewed	PI5L1_HUMAN	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PI(4)P 5-kinase-like protein 1) (PtdIns(4)P-5-kinase-like protein 1) (EC 2.7.1.68)	PIP5KL1	Homo sapiens (Human)	394	FUNCTION: May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. {ECO:0000250}.		negative regulation of cell migration [GO:0030336]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of protein phosphorylation [GO:0001933]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]	cell projection [GO:0042995]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524]	cell projection [GO:0042995]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524]; negative regulation of cell migration [GO:0030336]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of protein phosphorylation [GO:0001933]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures. {ECO:0000250}.
Q5T9G4	reviewed	ARM12_HUMAN	Armadillo repeat-containing protein 12	ARMC12 C6orf81	Homo sapiens (Human)	340	FUNCTION: Essential for male fertility and sperm mitochondrial sheath formation (By similarity). Required for proper mitochondrial elongation and coiling along the flagellum during the formation of the mitochondrial sheath (By similarity). Facilitates the growth and aggressiveness of neuroblastoma cells (PubMed:30026490). Increases the EZH2 activity and H3K27me3 levels in a RBBP4-dependent manner, and facilitates the enrichment of polycomb repressive complex 2 and H3K27me3 on gene promoters, resulting in transcriptional repression of tumor suppressors affecting the proliferation, invasion, and metastasis of tumor cells (PubMed:30026490). {ECO:0000250|UniProtKB:Q80X86, ECO:0000269|PubMed:30026490}.		flagellated sperm motility [GO:0030317]; positive regulation of cell growth [GO:0030307]; sperm mitochondrial sheath assembly [GO:0120317]	mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; flagellated sperm motility [GO:0030317]; positive regulation of cell growth [GO:0030307]; sperm mitochondrial sheath assembly [GO:0120317]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30026490}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q80X86}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q80X86}.
Q5T9L3	reviewed	WLS_HUMAN	Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373)	WLS C1orf139 GPR177 UNQ85/PRO18667	Homo sapiens (Human)	541	FUNCTION: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins (PubMed:34587386). Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). {ECO:0000250, ECO:0000269|PubMed:16678095, ECO:0000269|PubMed:16678096, ECO:0000269|PubMed:34587386}.		anterior/posterior axis specification [GO:0009948]; cementum mineralization [GO:0071529]; exocrine pancreas development [GO:0031017]; hindbrain development [GO:0030902]; intracellular protein transport [GO:0006886]; mesoderm formation [GO:0001707]; midbrain development [GO:0030901]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt protein secretion [GO:0061357]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt protein secretion [GO:0061355]; Wnt signaling pathway [GO:0016055]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	identical protein binding [GO:0042802]; Wnt-protein binding [GO:0017147]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; identical protein binding [GO:0042802]; Wnt-protein binding [GO:0017147]; anterior/posterior axis specification [GO:0009948]; cementum mineralization [GO:0071529]; exocrine pancreas development [GO:0031017]; hindbrain development [GO:0030902]; intracellular protein transport [GO:0006886]; mesoderm formation [GO:0001707]; midbrain development [GO:0030901]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt protein secretion [GO:0061357]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt protein secretion [GO:0061355]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16678095}; Multi-pass membrane protein {ECO:0000269|PubMed:16678095}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16678095}; Multi-pass membrane protein {ECO:0000269|PubMed:16678095}. Cell membrane {ECO:0000269|PubMed:18160347}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18160347}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:18160347}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:18160347}; Multi-pass membrane protein {ECO:0000255}. Note=Co-localizes with the adaptin AP2A2 at distinct punctae. {ECO:0000269|PubMed:18160347}.
Q5TA31	reviewed	RN187_HUMAN	E3 ubiquitin-protein ligase RNF187 (EC 2.3.2.27) (RING domain AP1 coactivator 1) (RACO-1) (RING finger protein 187) (RING-type E3 ubiquitin transferase RNF187)	RNF187	Homo sapiens (Human)	235	FUNCTION: E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8. {ECO:0000269|PubMed:20852630}.		positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20852630}. Nucleus {ECO:0000269|PubMed:20852630}. Note=Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus.
Q5TA45	reviewed	INT11_HUMAN	Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) (Protein related to CPSF subunits of 68 kDa) (RC-68)	INTS11 CPSF3L RC68	Homo sapiens (Human)	600	FUNCTION: Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267}.		regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA endonuclease activity [GO:0004521]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA endonuclease activity [GO:0004521]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15684398, ECO:0000269|PubMed:23904267}. Cytoplasm {ECO:0000269|PubMed:15684398, ECO:0000269|PubMed:23904267}.
Q5TA50	reviewed	CPTP_HUMAN	Ceramide-1-phosphate transfer protein (CPTP) (Glycolipid transfer protein domain-containing protein 1) (GLTP domain-containing protein 1)	CPTP GLTPD1	Homo sapiens (Human)	214	FUNCTION: Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (PubMed:28011644). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:29164996). {ECO:0000269|PubMed:23863933, ECO:0000269|PubMed:28011644, ECO:0000269|PubMed:29164996}.		ceramide 1-phosphate transport [GO:1902389]; ceramide transport [GO:0035627]; glycosphingolipid metabolic process [GO:0006687]; intermembrane lipid transfer [GO:0120009]; negative regulation of autophagy [GO:0010507]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]	ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; phospholipid binding [GO:0005543]; ceramide 1-phosphate transport [GO:1902389]; ceramide transport [GO:0035627]; glycosphingolipid metabolic process [GO:0006687]; intermembrane lipid transfer [GO:0120009]; negative regulation of autophagy [GO:0010507]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23863933}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:23863933}; Peripheral membrane protein {ECO:0000269|PubMed:23863933}. Cell membrane {ECO:0000269|PubMed:23863933}; Peripheral membrane protein {ECO:0000269|PubMed:23863933}; Cytoplasmic side {ECO:0000269|PubMed:23863933}. Endosome membrane {ECO:0000269|PubMed:23863933}; Peripheral membrane protein {ECO:0000269|PubMed:23863933}. Nucleus outer membrane {ECO:0000269|PubMed:23863933}; Peripheral membrane protein {ECO:0000269|PubMed:23863933}.
Q5TA76	reviewed	LCE3A_HUMAN	Late cornified envelope protein 3A (Late envelope protein 13)	LCE3A LEP13	Homo sapiens (Human)	89	FUNCTION: A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035). {ECO:0000269|PubMed:28634035, ECO:0000305|PubMed:28634035}.		defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; keratinization [GO:0031424]; killing of cells of another organism [GO:0031640]			defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; keratinization [GO:0031424]; killing of cells of another organism [GO:0031640]	
Q5TA77	reviewed	LCE3B_HUMAN	Late cornified envelope protein 3B (Late envelope protein 14)	LCE3B LEP14	Homo sapiens (Human)	95	FUNCTION: A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035). {ECO:0000269|PubMed:28634035, ECO:0000305|PubMed:28634035}.		defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; keratinization [GO:0031424]; killing of cells of another organism [GO:0031640]			defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; keratinization [GO:0031424]; killing of cells of another organism [GO:0031640]	
Q5TA78	reviewed	LCE4A_HUMAN	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A)	LCE4A LEP8 SPRL4A	Homo sapiens (Human)	99	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]		identical protein binding [GO:0042802]	identical protein binding [GO:0042802]; keratinization [GO:0031424]	
Q5TA79	reviewed	LCE2A_HUMAN	Late cornified envelope protein 2A (Late envelope protein 9)	LCE2A LEP9	Homo sapiens (Human)	106	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]			keratinization [GO:0031424]	
Q5TA81	reviewed	LCE2C_HUMAN	Late cornified envelope protein 2C (Late envelope protein 11)	LCE2C LEP11	Homo sapiens (Human)	110	FUNCTION: Precursors of the cornified envelope of the stratum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]		identical protein binding [GO:0042802]	identical protein binding [GO:0042802]; keratinization [GO:0031424]	
Q5TA82	reviewed	LCE2D_HUMAN	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A)	LCE2D LEP12 SPRL1A	Homo sapiens (Human)	110	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]			keratinization [GO:0031424]	
Q5TA89	reviewed	HES5_HUMAN	Transcription factor HES-5 (Class B basic helix-loop-helix protein 38) (bHLHb38) (Hairy and enhancer of split 5)	HES5 BHLHB38	Homo sapiens (Human)	166	FUNCTION: Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity). {ECO:0000250}.		anterior/posterior pattern specification [GO:0009952]; astrocyte differentiation [GO:0048708]; BMP signaling pathway [GO:0030509]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; cartilage development [GO:0051216]; cell adhesion [GO:0007155]; cell maturation [GO:0048469]; central nervous system myelination [GO:0022010]; comma-shaped body morphogenesis [GO:0072049]; establishment of epithelial cell polarity [GO:0090162]; forebrain radial glial cell differentiation [GO:0021861]; glial cell fate commitment [GO:0021781]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell stereocilium organization [GO:0060122]; metanephric nephron tubule morphogenesis [GO:0072282]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of forebrain neuron differentiation [GO:2000978]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; oligodendrocyte development [GO:0014003]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein-containing complex assembly [GO:0065003]; regulation of cell differentiation [GO:0045595]; regulation of epithelial cell proliferation [GO:0050678]; regulation of myelination [GO:0031641]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; S-shaped body morphogenesis [GO:0072050]; smoothened signaling pathway [GO:0007224]; specification of loop of Henle identity [GO:0072086]; telencephalon development [GO:0021537]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; astrocyte differentiation [GO:0048708]; BMP signaling pathway [GO:0030509]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; cartilage development [GO:0051216]; cell adhesion [GO:0007155]; cell maturation [GO:0048469]; central nervous system myelination [GO:0022010]; comma-shaped body morphogenesis [GO:0072049]; establishment of epithelial cell polarity [GO:0090162]; forebrain radial glial cell differentiation [GO:0021861]; glial cell fate commitment [GO:0021781]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell stereocilium organization [GO:0060122]; metanephric nephron tubule morphogenesis [GO:0072282]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of forebrain neuron differentiation [GO:2000978]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; oligodendrocyte development [GO:0014003]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein-containing complex assembly [GO:0065003]; regulation of cell differentiation [GO:0045595]; regulation of epithelial cell proliferation [GO:0050678]; regulation of myelination [GO:0031641]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; S-shaped body morphogenesis [GO:0072050]; smoothened signaling pathway [GO:0007224]; specification of loop of Henle identity [GO:0072086]; telencephalon development [GO:0021537]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Q5TAB7	reviewed	RIPP2_HUMAN	Protein ripply2	RIPPLY2 C6orf159	Homo sapiens (Human)	128	FUNCTION: Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity). {ECO:0000250|UniProtKB:Q2WG76}.		bone morphogenesis [GO:0060349]; determination of left/right symmetry [GO:0007368]; embryonic pattern specification [GO:0009880]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; ossification [GO:0001503]; post-anal tail morphogenesis [GO:0036342]; somite rostral/caudal axis specification [GO:0032525]; somitogenesis [GO:0001756]	nucleus [GO:0005634]		nucleus [GO:0005634]; bone morphogenesis [GO:0060349]; determination of left/right symmetry [GO:0007368]; embryonic pattern specification [GO:0009880]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; ossification [GO:0001503]; post-anal tail morphogenesis [GO:0036342]; somite rostral/caudal axis specification [GO:0032525]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2WG80}.
Q5TAP6	reviewed	UT14C_HUMAN	U3 small nucleolar RNA-associated protein 14 homolog C	UTP14C KIAA0266	Homo sapiens (Human)	766	FUNCTION: Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15289605}.	MISCELLANEOUS: Encoded by an autosomal retrotransposed copy of the X-linked gene UTP14A. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.	cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; rRNA processing [GO:0006364]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]		cytosol [GO:0005829]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]; cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; rRNA processing [GO:0006364]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
Q5TAQ9	reviewed	DCAF8_HUMAN	DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)	DCAF8 H326 WDR42A	Homo sapiens (Human)	597	FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.		protein ubiquitination [GO:0016567]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22500989}. Cytoplasm {ECO:0000269|PubMed:22500989}. Note=It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent. {ECO:0000269|PubMed:22500989}.
Q5TAT6	reviewed	CODA1_HUMAN	Collagen alpha-1(XIII) chain (COLXIIIA1)	COL13A1	Homo sapiens (Human)	717	FUNCTION: Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625). {ECO:0000250|UniProtKB:Q9R1N9, ECO:0000269|PubMed:10865988, ECO:0000269|PubMed:11956183, ECO:0000269|PubMed:26626625}.		cell differentiation [GO:0030154]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; morphogenesis of a branching structure [GO:0001763]; skeletal system development [GO:0001501]	cell-cell junction [GO:0005911]; collagen type XIII trimer [GO:0005600]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]	cell-cell junction [GO:0005911]; collagen type XIII trimer [GO:0005600]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; cell differentiation [GO:0030154]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; morphogenesis of a branching structure [GO:0001763]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11013208}; Single-pass type II membrane protein {ECO:0000269|PubMed:11013208}. Postsynaptic cell membrane {ECO:0000269|PubMed:26626625}.
Q5TAX3	reviewed	TUT4_HUMAN	Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11)	TUT4 KIAA0191 ZCCHC11	Homo sapiens (Human)	1644	FUNCTION: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:16643855, PubMed:19703396, PubMed:18172165) (By similarity). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}.		miRNA catabolic process [GO:0010587]; miRNA metabolic process [GO:0010586]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; oocyte maturation [GO:0001556]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; pre-miRNA processing [GO:0031054]; retrotransposon silencing by mRNA destabilization [GO:0141008]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; stem cell population maintenance [GO:0019827]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730]	miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; zinc ion binding [GO:0008270]; miRNA catabolic process [GO:0010587]; miRNA metabolic process [GO:0010586]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; oocyte maturation [GO:0001556]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; pre-miRNA processing [GO:0031054]; retrotransposon silencing by mRNA destabilization [GO:0141008]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16643855}. Cytoplasm {ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:30122351}. Note=Mainly cytoplasmic (PubMed:19703396, PubMed:25480299). Translocates into the cytoplasm following treatment of the cell with LPS (PubMed:16643855). Co-enriched in cytoplasmic foci with MOV10 (PubMed:30122351). {ECO:0000269|PubMed:30122351}.
Q5TB30	reviewed	DEP1A_HUMAN	DEP domain-containing protein 1A	DEPDC1 DEPDC1A	Homo sapiens (Human)	811	FUNCTION: May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269|PubMed:20587513}.		intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892]	nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	GTPase activator activity [GO:0005096]	nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; GTPase activator activity [GO:0005096]; intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17452976, ECO:0000269|PubMed:20587513}. Note=Colocalizes with ZNF224 at the nucleus.
Q5TB80	reviewed	CE162_HUMAN	Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog)	CEP162 C6orf84 KIAA1009 QN1	Homo sapiens (Human)	1403	FUNCTION: Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. {ECO:0000269|PubMed:23644468}.	MISCELLANEOUS: Promotes ectopic assembly of transition zone components at cilia tips when targeted outside distal ends of centrioles, generating extra-long cilia with strikingly swollen tips. {ECO:0000305|PubMed:23644468}.	cilium assembly [GO:0060271]	axonemal microtubule [GO:0005879]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spindle [GO:0005819]		axonemal microtubule [GO:0005879]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=Localizes to the distal end of centrioles throughout the cell cycle. During ciliogenesis, found at the cilia base. Localizes to spindle microtubules during mitosis.
Q5TBA9	reviewed	FRY_HUMAN	Protein furry homolog	FRY C13orf14	Homo sapiens (Human)	3013	FUNCTION: Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}.		cell morphogenesis [GO:0000902]; negative regulation of tubulin deacetylation [GO:1904428]; neuron projection development [GO:0031175]	cell cortex [GO:0005938]; microtubule organizing center [GO:0005815]; site of polarized growth [GO:0030427]; spindle pole [GO:0000922]	enzyme inhibitor activity [GO:0004857]	cell cortex [GO:0005938]; microtubule organizing center [GO:0005815]; site of polarized growth [GO:0030427]; spindle pole [GO:0000922]; enzyme inhibitor activity [GO:0004857]; cell morphogenesis [GO:0000902]; negative regulation of tubulin deacetylation [GO:1904428]; neuron projection development [GO:0031175]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22753416}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22753416}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:22753416}. Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase, to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle.
Q5TBB1	reviewed	RNH2B_HUMAN	Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B)	RNASEH2B DLEU8	Homo sapiens (Human)	312	FUNCTION: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}.		fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; mismatch repair [GO:0006298]; negative regulation of gene expression [GO:0010629]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of DNA damage checkpoint [GO:2000001]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; ribonucleotide metabolic process [GO:0009259]; RNA catabolic process [GO:0006401]	nucleoplasm [GO:0005654]; ribonuclease H2 complex [GO:0032299]		nucleoplasm [GO:0005654]; ribonuclease H2 complex [GO:0032299]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; mismatch repair [GO:0006298]; negative regulation of gene expression [GO:0010629]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of DNA damage checkpoint [GO:2000001]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; ribonucleotide metabolic process [GO:0009259]; RNA catabolic process [GO:0006401]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5TC82	reviewed	RC3H1_HUMAN	Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198)	RC3H1 KIAA2025 RNF198	Homo sapiens (Human)	1133	FUNCTION: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:25026078, PubMed:31636267). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:25504471, PubMed:25026078). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406, PubMed:31636267). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). {ECO:0000250|UniProtKB:Q4VGL6, ECO:0000269|PubMed:25026078, ECO:0000269|PubMed:25504471, ECO:0000269|PubMed:25697406, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:31636267}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; B cell homeostasis [GO:0001782]; cellular response to interleukin-1 [GO:0071347]; lymph node development [GO:0048535]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of germinal center formation [GO:0002635]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper cell differentiation [GO:0045623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; P-body assembly [GO:0033962]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; post-transcriptional regulation of gene expression [GO:0010608]; protein polyubiquitination [GO:0000209]; regulation of germinal center formation [GO:0002634]; regulation of miRNA metabolic process [GO:2000628]; regulation of mRNA stability [GO:0043488]; regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900151]; regulation of T cell receptor signaling pathway [GO:0050856]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]; T follicular helper cell differentiation [GO:0061470]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932]	CCR4-NOT complex binding [GO:1905762]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932]; CCR4-NOT complex binding [GO:1905762]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; B cell homeostasis [GO:0001782]; cellular response to interleukin-1 [GO:0071347]; lymph node development [GO:0048535]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of germinal center formation [GO:0002635]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper cell differentiation [GO:0045623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; P-body assembly [GO:0033962]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; post-transcriptional regulation of gene expression [GO:0010608]; protein polyubiquitination [GO:0000209]; regulation of germinal center formation [GO:0002634]; regulation of miRNA metabolic process [GO:2000628]; regulation of mRNA stability [GO:0043488]; regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900151]; regulation of T cell receptor signaling pathway [GO:0050856]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]; T follicular helper cell differentiation [GO:0061470]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:31636267}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q4VGL6}. Note=During stress, such as that induced by arsenite treatment, localizes to cytosolic stress granules (By similarity). Localization to stress granules, but not to P-bodies, depends upon the RING-type zinc finger (By similarity). ICOS repression may correlate with the localization to P-bodies, not to stress granules (By similarity). {ECO:0000250|UniProtKB:Q4VGL6}.
Q5TCH4	reviewed	CP4AM_HUMAN	Cytochrome P450 4A22 (CYPIVA22) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)	CYP4A22	Homo sapiens (Human)	519	FUNCTION: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis. {ECO:0000269|PubMed:10860550, ECO:0000269|PubMed:15611369}.		arachidonic acid metabolic process [GO:0019369]; icosanoid biosynthetic process [GO:0046456]; kidney development [GO:0001822]; lauric acid metabolic process [GO:0048252]; linoleic acid metabolic process [GO:0043651]; lipid hydroxylation [GO:0002933]	endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]	16-hydroxypalmitate dehydrogenase activity [GO:0103002]; alkane 1-monooxygenase activity [GO:0018685]; arachidonic acid monooxygenase activity [GO:0008391]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; medium-chain fatty acid omega-hydroxylase activity [GO:0140981]	endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; 16-hydroxypalmitate dehydrogenase activity [GO:0103002]; alkane 1-monooxygenase activity [GO:0018685]; arachidonic acid monooxygenase activity [GO:0008391]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; medium-chain fatty acid omega-hydroxylase activity [GO:0140981]; arachidonic acid metabolic process [GO:0019369]; icosanoid biosynthetic process [GO:0046456]; kidney development [GO:0001822]; lauric acid metabolic process [GO:0048252]; linoleic acid metabolic process [GO:0043651]; lipid hydroxylation [GO:0002933]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q5TCM9	reviewed	LCE5A_HUMAN	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A)	LCE5A LEP18 SPRL5A	Homo sapiens (Human)	118	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]		identical protein binding [GO:0042802]	identical protein binding [GO:0042802]; keratinization [GO:0031424]	
Q5TCQ9	reviewed	MAGI3_HUMAN	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3)	MAGI3 KIAA1634	Homo sapiens (Human)	1481	FUNCTION: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. {ECO:0000269|PubMed:10748157}.	MISCELLANEOUS: MAGI3 PDZ domains are used to design peptide ligands that bind and inhibit PDZ domains.	apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385]; apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Nucleus {ECO:0000250}. Note=Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions (By similarity). {ECO:0000250}.
Q5TCS8	reviewed	KAD9_HUMAN	Adenylate kinase 9 (AK 9) (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase domain-containing protein 1) (Adenylate kinase domain-containing protein 2)	AK9 AKD1 AKD2 C6orf199 C6orf224	Homo sapiens (Human)	1911	FUNCTION: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP. {ECO:0000269|PubMed:23416111}.		phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside monophosphate kinase activity [GO:0050145]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside monophosphate kinase activity [GO:0050145]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23416111}. Nucleus {ECO:0000269|PubMed:23416111}.
Q5TCX8	reviewed	M3K21_HUMAN	Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)	MAP3K21 KIAA1804 MLK4	Homo sapiens (Human)	1036	FUNCTION: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}.		protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	
Q5TCY1	reviewed	TTBK1_HUMAN	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase)	TTBK1 BDTK KIAA1855	Homo sapiens (Human)	1321	FUNCTION: Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. {ECO:0000269|PubMed:16923168}.		learning or memory [GO:0007611]; negative regulation of gene expression [GO:0010629]; negative regulation of protein binding [GO:0032091]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of astrocyte activation [GO:0061890]; positive regulation of cyclin-dependent protein kinase activity [GO:1904031]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of gene expression [GO:0010628]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of protein polymerization [GO:0032273]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762]	cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; learning or memory [GO:0007611]; negative regulation of gene expression [GO:0010629]; negative regulation of protein binding [GO:0032091]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of astrocyte activation [GO:0061890]; positive regulation of cyclin-dependent protein kinase activity [GO:1904031]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of gene expression [GO:0010628]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of protein polymerization [GO:0032273]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16923168}.
Q5TCZ1	reviewed	SPD2A_HUMAN	SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)	SH3PXD2A FISH KIAA0418 SH3MD1 TKS5	Homo sapiens (Human)	1133	FUNCTION: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}.	MISCELLANEOUS: [Isoform 3]: Gene prediction based on similarity to mouse ortholog and partial transcript data. {ECO:0000305}.	in utero embryonic development [GO:0001701]; osteoclast fusion [GO:0072675]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; podosome [GO:0002102]	phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protease binding [GO:0002020]; superoxide-generating NADPH oxidase activator activity [GO:0016176]	anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; podosome [GO:0002102]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protease binding [GO:0002020]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; in utero embryonic development [GO:0001701]; osteoclast fusion [GO:0072675]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
Q5TD94	reviewed	RSH4A_HUMAN	Radial spoke head protein 4 homolog A (Radial spoke head-like protein 3)	RSPH4A RSHL3	Homo sapiens (Human)	716	FUNCTION: Component of the axonemal radial spoke head which plays an important role in ciliary motility (PubMed:19200523). Essential for triplet radial spokes (RS1, RS2 and RS3) head assembly in the motile cilia (By similarity). {ECO:0000250|UniProtKB:Q8BYM7, ECO:0000269|PubMed:19200523}.		axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; maintenance of ciliary planar beating movement pattern [GO:0120221]; radial spoke assembly [GO:0062177]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; radial spoke head 1 [GO:0120336]; radial spoke head 2 [GO:0120337]; radial spoke head 3 [GO:0120338]		9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; radial spoke head 1 [GO:0120336]; radial spoke head 2 [GO:0120337]; radial spoke head 3 [GO:0120338]; axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; maintenance of ciliary planar beating movement pattern [GO:0120221]; radial spoke assembly [GO:0062177]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:19200523}.
Q5TD97	reviewed	FHL5_HUMAN	Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP-responsive element modulator in testis) (Activator of CREM in testis)	FHL5 ACT	Homo sapiens (Human)	284	FUNCTION: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner. {ECO:0000269|PubMed:11327716}.		positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleus [GO:0005634]; Z disc [GO:0030018]	metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]	nucleus [GO:0005634]; Z disc [GO:0030018]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11327716}. Note=Nuclei of round and elongated spermatids.
Q5TDH0	reviewed	DDI2_HUMAN	Protein DDI1 homolog 2 (EC 3.4.23.-)	DDI2	Homo sapiens (Human)	399	FUNCTION: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). {ECO:0000269|PubMed:27528193, ECO:0000269|PubMed:27676298, ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}.		cellular response to hydroxyurea [GO:0072711]; proteasomal protein catabolic process [GO:0010498]; protein processing [GO:0016485]; regulation of DNA stability [GO:0097752]; regulation of protein stability [GO:0031647]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	aspartic-type endopeptidase activity [GO:0004190]; identical protein binding [GO:0042802]; ubiquitin binding [GO:0043130]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; aspartic-type endopeptidase activity [GO:0004190]; identical protein binding [GO:0042802]; ubiquitin binding [GO:0043130]; cellular response to hydroxyurea [GO:0072711]; proteasomal protein catabolic process [GO:0010498]; protein processing [GO:0016485]; regulation of DNA stability [GO:0097752]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:27528193}. Chromosome {ECO:0000269|PubMed:29290612}.
Q5TEJ8	reviewed	THMS2_HUMAN	Protein THEMIS2 (Induced by contact to basement membrane 1 protein) (Protein ICB-1) (Thymocyte-expressed molecule involved in selection protein 2)	THEMIS2 C1orf38 ICB1	Homo sapiens (Human)	643	FUNCTION: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity). {ECO:0000250|UniProtKB:Q91YX0, ECO:0000269|PubMed:20644716}.		cell adhesion [GO:0007155]; inflammatory response [GO:0006954]; regulation of B cell activation [GO:0050864]; T cell receptor signaling pathway [GO:0050852]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; cell adhesion [GO:0007155]; inflammatory response [GO:0006954]; regulation of B cell activation [GO:0050864]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91YX0}. Cytoplasm {ECO:0000250|UniProtKB:Q91YX0}.
Q5TEU4	reviewed	NDUF5_HUMAN	Arginine-hydroxylase NDUFAF5, mitochondrial (EC 1.-.-.-) (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5) (Putative methyltransferase NDUFAF5) (EC 2.1.1.-)	NDUFAF5 C20orf7	Homo sapiens (Human)	345	FUNCTION: Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages (PubMed:18940309, PubMed:27226634). Acts by mediating hydroxylation of 'Arg-111' of NDUFS7 (PubMed:27226634). May also have methyltransferase activity (Probable). {ECO:0000269|PubMed:18940309, ECO:0000269|PubMed:27226634, ECO:0000305}.		methylation [GO:0032259]; mitochondrial respiratory chain complex I assembly [GO:0032981]; peptidyl-arginine hydroxylation [GO:0030961]	matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	oxidoreductase activity [GO:0016491]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; oxidoreductase activity [GO:0016491]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; methylation [GO:0032259]; mitochondrial respiratory chain complex I assembly [GO:0032981]; peptidyl-arginine hydroxylation [GO:0030961]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:18940309, ECO:0000269|PubMed:27226634, ECO:0000269|PubMed:35614220}. Note=Peripherally localized on the matrix face of the mitochondrial inner membrane. {ECO:0000269|PubMed:18940309}.
Q5TGU0	reviewed	TSPO2_HUMAN	Translocator protein 2 (Peripheral-type benzodiazepine receptor-like protein 1)	TSPO2 BZRPL1	Homo sapiens (Human)	170	FUNCTION: Cholesterol-binding protein involved in the redistribution of cholesterol from lipid droplets to the endoplasmic reticulum (PubMed:19729679). Required to meet cholesterol demands during erythropoietic differentiation (PubMed:19729679). May play a role in transport processes at the plasma membrane of erythrocytes, including regulating VDAC-mediated ATP export, and import of the heme precursors protoporphyrin IX and 5-aminolevulinic acid (PubMed:27641616, PubMed:30061676, PubMed:31989647). {ECO:0000269|PubMed:19729679, ECO:0000269|PubMed:27641616, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31989647}.		5-aminolevulinic acid import across plasma membrane [GO:0140484]; enucleate erythrocyte differentiation [GO:0043353]; import across plasma membrane [GO:0098739]; intracellular cholesterol transport [GO:0032367]; lipid droplet organization [GO:0034389]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]	5-aminolevulinic acid transmembrane transporter activity [GO:0140485]; cholesterol binding [GO:0015485]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; 5-aminolevulinic acid transmembrane transporter activity [GO:0140485]; cholesterol binding [GO:0015485]; 5-aminolevulinic acid import across plasma membrane [GO:0140484]; enucleate erythrocyte differentiation [GO:0043353]; import across plasma membrane [GO:0098739]; intracellular cholesterol transport [GO:0032367]; lipid droplet organization [GO:0034389]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19729679}; Multi-pass membrane protein {ECO:0000269|PubMed:19729679}. Cell membrane {ECO:0000269|PubMed:27641616, ECO:0000269|PubMed:31989647}; Multi-pass membrane protein. Note=Localizes to the plasma membrane and intracellular membranes in developing and mature erythrocytes. {ECO:0000269|PubMed:27641616, ECO:0000269|PubMed:31989647}.
Q5TGY3	reviewed	AHDC1_HUMAN	Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1)	AHDC1	Homo sapiens (Human)	1603	FUNCTION: Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}.		cell differentiation [GO:0030154]; mesoderm formation [GO:0001707]; skin morphogenesis [GO:0043589]	chromosome [GO:0005694]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; promoter-enhancer loop anchoring activity [GO:0140585]	chromosome [GO:0005694]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; promoter-enhancer loop anchoring activity [GO:0140585]; cell differentiation [GO:0030154]; mesoderm formation [GO:0001707]; skin morphogenesis [GO:0043589]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33644933}. Chromosome {ECO:0000269|PubMed:35585237}. Note=Associates with promoter and enhancer regions. {ECO:0000269|PubMed:35585237}.
Q5TGZ0	reviewed	MIC10_HUMAN	MICOS complex subunit MIC10 (Mitochondrial inner membrane organizing system protein 1)	MICOS10 C1orf151 MIC10 MINOS1	Homo sapiens (Human)	78	FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22114354}.		cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]	MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]		MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:22114354}; Single-pass membrane protein {ECO:0000269|PubMed:22114354}. Note=The C-terminus is located in the intermembrane space (By similarity), while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (PubMed:22114354). {ECO:0000250, ECO:0000269|PubMed:22114354}.
Q5THJ4	reviewed	VP13D_HUMAN	Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D)	VPS13D KIAA0453	Homo sapiens (Human)	4388	FUNCTION: Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}.		lipid transport [GO:0006869]; mitochondrion organization [GO:0007005]; positive regulation of mitophagy [GO:1901526]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]	extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]		extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; lipid transport [GO:0006869]; mitochondrion organization [GO:0007005]; positive regulation of mitophagy [GO:1901526]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]	
Q5THR3	reviewed	EFCB6_HUMAN	EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP)	EFCAB6 DJBP KIAA1672	Homo sapiens (Human)	1501	FUNCTION: Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex (PubMed:12612053). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (Probable). {ECO:0000269|PubMed:12612053, ECO:0000305}.			cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]	calcium ion binding [GO:0005509]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12612053}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}.
Q5TIA1	reviewed	MEI1_HUMAN	Meiosis inhibitor protein 1 (Meiosis defective protein 1)	MEI1	Homo sapiens (Human)	1274	FUNCTION: Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity). {ECO:0000250|UniProtKB:Q9D4I2}.		meiosis I [GO:0007127]			meiosis I [GO:0007127]	
Q5TKA1	reviewed	LIN9_HUMAN	Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein)	LIN9 BARA TGS	Homo sapiens (Human)	542	FUNCTION: Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}.		cell cycle [GO:0007049]; DNA biosynthetic process [GO:0071897]; DNA-templated transcription [GO:0006351]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; reproduction [GO:0000003]	nucleoplasm [GO:0005654]; transcription repressor complex [GO:0017053]	DNA binding [GO:0003677]	nucleoplasm [GO:0005654]; transcription repressor complex [GO:0017053]; DNA binding [GO:0003677]; cell cycle [GO:0007049]; DNA biosynthetic process [GO:0071897]; DNA-templated transcription [GO:0006351]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; reproduction [GO:0000003]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}. Note=Found in perinucleolar structures. Associated with chromatin.
Q5TZA2	reviewed	CROCC_HUMAN	Rootletin (Ciliary rootlet coiled-coil protein)	CROCC KIAA0445	Homo sapiens (Human)	2017	FUNCTION: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}.		cellular homeostasis [GO:0019725]; centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098]; ciliary basal body organization [GO:0032053]; epithelial structure maintenance [GO:0010669]; establishment of localization in cell [GO:0051649]; establishment of organelle localization [GO:0051656]; photoreceptor cell maintenance [GO:0045494]; positive regulation of cilium assembly [GO:0045724]; positive regulation of protein localization to cilium [GO:1903566]; protein localization [GO:0008104]; protein localization to organelle [GO:0033365]	9+2 motile cilium [GO:0097729]; actin cytoskeleton [GO:0015629]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary rootlet [GO:0035253]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; subapical part of cell [GO:0120219]	actin binding [GO:0003779]; kinesin binding [GO:0019894]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]	9+2 motile cilium [GO:0097729]; actin cytoskeleton [GO:0015629]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary rootlet [GO:0035253]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; subapical part of cell [GO:0120219]; actin binding [GO:0003779]; kinesin binding [GO:0019894]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; cellular homeostasis [GO:0019725]; centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098]; ciliary basal body organization [GO:0032053]; epithelial structure maintenance [GO:0010669]; establishment of localization in cell [GO:0051649]; establishment of organelle localization [GO:0051656]; photoreceptor cell maintenance [GO:0045494]; positive regulation of cilium assembly [GO:0045724]; positive regulation of protein localization to cilium [GO:1903566]; protein localization [GO:0008104]; protein localization to organelle [GO:0033365]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27623382}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27623382, ECO:0000269|PubMed:31974111}. Note=In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase. {ECO:0000269|PubMed:14654843}.
Q5TZF3	reviewed	ANR45_HUMAN	Ankyrin repeat domain-containing protein 45	ANKRD45	Homo sapiens (Human)	266	FUNCTION: May play a role during cell division. {ECO:0000269|PubMed:31208154}.		cell population proliferation [GO:0008283]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; midbody [GO:0030496]		cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; midbody [GO:0030496]; cell population proliferation [GO:0008283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31208154}. Midbody, Midbody ring {ECO:0000269|PubMed:31208154}. Cleavage furrow {ECO:0000269|PubMed:31208154}. Note=Distribution is highly dynamic during mitosis. Not detected during interphase, localized to cytoplasm during metaphase, to cleavage furrow during anaphase and telophase, and to midbody ring during cytokinesis. {ECO:0000269|PubMed:31208154}.
Q5TZK3	reviewed	FAM74_HUMAN	Protein FAM74A4/A6	FAM74A4 FAM74A2; FAM74A6	Homo sapiens (Human)	123							
Q5U5Q3	reviewed	MEX3C_HUMAN	RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C)	MEX3C RKHD2 RNF194 BM-013	Homo sapiens (Human)	659	FUNCTION: E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}.		chondrocyte hypertrophy [GO:0003415]; energy homeostasis [GO:0097009]; regulation of fat cell differentiation [GO:0045598]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; chondrocyte hypertrophy [GO:0003415]; energy homeostasis [GO:0097009]; regulation of fat cell differentiation [GO:0045598]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17267406}. Nucleus {ECO:0000269|PubMed:17267406}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.
Q5U5X0	reviewed	LYRM7_HUMAN	Complex III assembly factor LYRM7 (LYR motif-containing protein 7)	LYRM7 C5orf31 MZM1L	Homo sapiens (Human)	104	FUNCTION: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. {ECO:0000269|PubMed:23168492}.		cellular respiration [GO:0045333]; mitochondrial respiratory chain complex III assembly [GO:0034551]	mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]	protein folding chaperone [GO:0044183]	mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; protein folding chaperone [GO:0044183]; cellular respiration [GO:0045333]; mitochondrial respiratory chain complex III assembly [GO:0034551]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:23168492}.
Q5U5Z8	reviewed	CBPC2_HUMAN	Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) (Protein deglutamylase CCP2)	AGBL2 CCP2	Homo sapiens (Human)	902	FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. {ECO:0000250|UniProtKB:Q8CDK2}.		protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8CDK2}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23085998}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23085998}. Note=Colocalizes with gamma-tubulin in the centrioles and with glutamylated tubulin in the basal bodies of ciliated cells. {ECO:0000269|PubMed:23085998}.
Q5U651	reviewed	RAIN_HUMAN	Ras-interacting protein 1 (Rain)	RASIP1	Homo sapiens (Human)	963	FUNCTION: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}.		angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; negative regulation of autophagy [GO:0010507]; negative regulation of membrane permeability [GO:1905709]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000299]; positive regulation of integrin activation [GO:0033625]; regulation of GTPase activity [GO:0043087]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570]	cell-cell junction [GO:0005911]; Golgi stack [GO:0005795]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	GTPase binding [GO:0051020]; protein homodimerization activity [GO:0042803]	cell-cell junction [GO:0005911]; Golgi stack [GO:0005795]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; GTPase binding [GO:0051020]; protein homodimerization activity [GO:0042803]; angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; negative regulation of autophagy [GO:0010507]; negative regulation of membrane permeability [GO:1905709]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000299]; positive regulation of integrin activation [GO:0033625]; regulation of GTPase activity [GO:0043087]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15031288}. Golgi apparatus, Golgi stack {ECO:0000269|PubMed:15031288}. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.
Q5UCC4	reviewed	EMC10_HUMAN	ER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1)	EMC10 C19orf63 INM02 UNQ764/PRO1556	Homo sapiens (Human)	262	FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways (PubMed:28931551). {ECO:0000269|PubMed:28931551, ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305}.		angiogenesis [GO:0001525]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020]		EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020]; angiogenesis [GO:0001525]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000305|PubMed:22119785, ECO:0000305|PubMed:32439656, ECO:0000305|PubMed:32459176}; Single-pass type I membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:19570817, ECO:0000269|PubMed:20680400, ECO:0000269|PubMed:28931551}.
Q5UE93	reviewed	PI3R6_HUMAN	Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP)	PIK3R6 C17orf38	Homo sapiens (Human)	754	FUNCTION: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269|PubMed:21393242}.		angiogenesis [GO:0001525]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of angiogenesis [GO:0045766]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of T cell differentiation [GO:0045582]; regulation of natural killer cell mediated cytotoxicity [GO:0042269]	cytosol [GO:0005829]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]	cytosol [GO:0005829]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; angiogenesis [GO:0001525]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of angiogenesis [GO:0045766]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of T cell differentiation [GO:0045582]; regulation of natural killer cell mediated cytotoxicity [GO:0042269]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3U6Q4}. Cell membrane {ECO:0000250|UniProtKB:Q3U6Q4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3U6Q4}. Note=Translocated to the plasma membrane in a Ras-dependent manner. {ECO:0000250|UniProtKB:Q3U6Q4}.
Q5UIP0	reviewed	RIF1_HUMAN	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)	RIF1	Homo sapiens (Human)	2472	FUNCTION: Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.		cell cycle [GO:0007049]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; somatic stem cell population maintenance [GO:0035019]; subtelomeric heterochromatin formation [GO:0031509]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]	chromatin [GO:0000785]; chromosome, telomeric repeat region [GO:0140445]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; spindle midzone [GO:0051233]		chromatin [GO:0000785]; chromosome, telomeric repeat region [GO:0140445]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; spindle midzone [GO:0051233]; cell cycle [GO:0007049]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; somatic stem cell population maintenance [GO:0035019]; subtelomeric heterochromatin formation [GO:0031509]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15583028}. Chromosome {ECO:0000250|UniProtKB:Q6PR54}. Chromosome, telomere {ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:15583028}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15583028}. Note=Following interaction with TP53BP1, recruited to sites of DNA damage, such as DSBs (By similarity). Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs) (PubMed:15342490). Does not associate with normal telomere structures (PubMed:15342490, PubMed:15583028). Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase (PubMed:15583028). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:15583028}.
Q5VIR6	reviewed	VPS53_HUMAN	Vacuolar protein sorting-associated protein 53 homolog	VPS53 PP13624	Homo sapiens (Human)	832	FUNCTION: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:18367545, ECO:0000269|PubMed:25799061}.		endocytic recycling [GO:0032456]; lysosomal transport [GO:0007041]; protein targeting to lysosome [GO:0006622]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]	cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588]		cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588]; endocytic recycling [GO:0032456]; lysosomal transport [GO:0007041]; protein targeting to lysosome [GO:0006622]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:18367545}; Peripheral membrane protein. Endosome membrane {ECO:0000269|PubMed:18367545}; Peripheral membrane protein. Recycling endosome {ECO:0000269|PubMed:25799061}. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061). {ECO:0000269|PubMed:25799061}.
Q5VSL9	reviewed	STRP1_HUMAN	Striatin-interacting protein 1 (Protein FAM40A)	STRIP1 FAM40A KIAA1761	Homo sapiens (Human)	837	FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000269|PubMed:21834987}.		cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21834987}. Note=Enriched on the plasma membrane.
Q5VST6	reviewed	AB17B_HUMAN	Alpha/beta hydrolase domain-containing protein 17B (Abhydrolase domain-containing protein 17B) (EC 3.1.2.22)	ABHD17B C9orf77 FAM108B1 CGI-67	Homo sapiens (Human)	288	FUNCTION: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913). {ECO:0000250|UniProtKB:Q7M759, ECO:0000269|PubMed:26701913}.		negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; protein depalmitoylation [GO:0002084]; proteolysis [GO:0006508]; regulation of dendritic spine maintenance [GO:1902950]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization to synapse [GO:1902473]	dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; recycling endosome membrane [GO:0055038]	palmitoyl-(protein) hydrolase activity [GO:0008474]; serine-type peptidase activity [GO:0008236]	dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; recycling endosome membrane [GO:0055038]; palmitoyl-(protein) hydrolase activity [GO:0008474]; serine-type peptidase activity [GO:0008236]; negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; protein depalmitoylation [GO:0002084]; proteolysis [GO:0006508]; regulation of dendritic spine maintenance [GO:1902950]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization to synapse [GO:1902473]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7M759}; Lipid-anchor {ECO:0000250|UniProtKB:Q7M759}; Cytoplasmic side {ECO:0000250|UniProtKB:Q7M759}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q7M759}; Lipid-anchor {ECO:0000250|UniProtKB:Q7M759}; Cytoplasmic side {ECO:0000250|UniProtKB:Q7M759}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q7M759}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q7M759}.
Q5VST9	reviewed	OBSCN_HUMAN	Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK)	OBSCN KIAA1556 KIAA1639	Homo sapiens (Human)	7968	FUNCTION: Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}.	MISCELLANEOUS: [Isoform 3]: Lacks the kinase domain. Initially described as obscurin. {ECO:0000305}.	phosphorylation [GO:0016310]; protein localization to M-band [GO:0036309]; regulation of small GTPase mediated signal transduction [GO:0051056]; sarcomere organization [GO:0045214]	cytosol [GO:0005829]; M band [GO:0031430]; myofibril [GO:0030016]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; Z disc [GO:0030018]	ankyrin binding [GO:0030506]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]	cytosol [GO:0005829]; M band [GO:0031430]; myofibril [GO:0030016]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; Z disc [GO:0030018]; ankyrin binding [GO:0030506]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]; phosphorylation [GO:0016310]; protein localization to M-band [GO:0036309]; regulation of small GTPase mediated signal transduction [GO:0051056]; sarcomere organization [GO:0045214]	SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:12527750}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:12527750}. Note=In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z-disk (PubMed:12527750). Isoform 3 colocalizes with ANK1 isoform Mu17/ank1.5 at the M-line in differentiated skeletal muscle cells (PubMed:12527750).; SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:A2AAJ9}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:A2AAJ9}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:A2AAJ9}. Nucleus {ECO:0000250|UniProtKB:A2AAJ9}. Note=Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles. {ECO:0000250|UniProtKB:A2AAJ9}.
Q5VSY0	reviewed	GKAP1_HUMAN	G kinase-anchoring protein 1 (cGMP-dependent protein kinase-anchoring protein of 42 kDa)	GKAP1 GKAP42 FKSG21	Homo sapiens (Human)	366	FUNCTION: Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. {ECO:0000250|UniProtKB:Q9JMB0}.		positive regulation of insulin receptor signaling pathway [GO:0046628]; signal transduction [GO:0007165]	Golgi apparatus [GO:0005794]	identical protein binding [GO:0042802]	Golgi apparatus [GO:0005794]; identical protein binding [GO:0042802]; positive regulation of insulin receptor signaling pathway [GO:0046628]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q9JMB0}.
Q5VT06	reviewed	CE350_HUMAN	Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa)	CEP350 CAP350 KIAA0480 GM133	Homo sapiens (Human)	3117	FUNCTION: Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}.		microtubule anchoring [GO:0034453]; non-motile cilium assembly [GO:1905515]; protein localization to centrosome [GO:0071539]	cell projection [GO:0042995]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819]	microtubule binding [GO:0008017]	cell projection [GO:0042995]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819]; microtubule binding [GO:0008017]; microtubule anchoring [GO:0034453]; non-motile cilium assembly [GO:1905515]; protein localization to centrosome [GO:0071539]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16314388}. Nucleus {ECO:0000269|PubMed:15615782}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28659385}. Note=Associated with mitotic spindles (PubMed:16314388). Nuclear, in discrete foci. Associated with intermediate filaments (PubMed:15615782). Also present in the pericentrosomal area (PubMed:17878239). Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole (PubMed:28625565). Localizes to the distal end of the centriole on the subdistal appendage region (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}.
Q5VT25	reviewed	MRCKA_HUMAN	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)	CDC42BPA KIAA0451	Homo sapiens (Human)	1732	FUNCTION: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.		actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell migration [GO:0016477]; protein phosphorylation [GO:0006468]	actomyosin [GO:0042641]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actomyosin [GO:0042641]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell migration [GO:0016477]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54874}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q3UU96}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent. Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner. {ECO:0000250|UniProtKB:O54874, ECO:0000250|UniProtKB:Q3UU96}.
Q5VT52	reviewed	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain-containing protein 2	RPRD2 KIAA0460 HSPC099	Homo sapiens (Human)	1461			mRNA 3'-end processing [GO:0031124]	nucleoplasm [GO:0005654]; transcription preinitiation complex [GO:0097550]	RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993]	nucleoplasm [GO:0005654]; transcription preinitiation complex [GO:0097550]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993]; mRNA 3'-end processing [GO:0031124]	
Q5VT66	reviewed	MARC1_HUMAN	Mitochondrial amidoxime-reducing component 1 (mARC1) (EC 1.7.-.-) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 1) (MOSC domain-containing protein 1) (Moco sulfurase C-terminal domain-containing protein 1)	MTARC1 MARC1 MOSC1	Homo sapiens (Human)	337	FUNCTION: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045, PubMed:19053771). {ECO:0000269|PubMed:19053771, ECO:0000269|PubMed:21029045, ECO:0000269|PubMed:30397129}.		cellular detoxification of nitrogen compound [GO:0070458]; detoxification of nitrogen compound [GO:0051410]; nitrate metabolic process [GO:0042126]; nitric oxide biosynthetic process [GO:0006809]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nitric-oxide synthase complex [GO:1903958]	molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940]; nitrite reductase activity [GO:0098809]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; pyridoxal phosphate binding [GO:0030170]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nitric-oxide synthase complex [GO:1903958]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940]; nitrite reductase activity [GO:0098809]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; pyridoxal phosphate binding [GO:0030170]; cellular detoxification of nitrogen compound [GO:0070458]; detoxification of nitrogen compound [GO:0051410]; nitrate metabolic process [GO:0042126]; nitric oxide biosynthetic process [GO:0006809]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:23086957}; Single-pass type II membrane protein {ECO:0000269|PubMed:23086957}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Mitochondrial import is mediated by AA 1-40 and requires ATP.
Q5VT99	reviewed	LRC38_HUMAN	Leucine-rich repeat-containing protein 38 (BK channel auxiliary gamma subunit LRRC38)	LRRC38	Homo sapiens (Human)	294	FUNCTION: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. {ECO:0000269|PubMed:22547800}.		positive regulation of voltage-gated potassium channel activity [GO:1903818]; potassium ion transmembrane transport [GO:0071805]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	potassium channel activator activity [GO:0099104]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; potassium channel activator activity [GO:0099104]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; positive regulation of voltage-gated potassium channel activity [GO:1903818]; potassium ion transmembrane transport [GO:0071805]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q5VTB9	reviewed	RN220_HUMAN	E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220)	RNF220 C1orf164	Homo sapiens (Human)	566	FUNCTION: E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658, PubMed:33964137). Plays a critical role in the regulation of nuclear lamina (PubMed:33964137). {ECO:0000250|UniProtKB:Q6PDX6, ECO:0000269|PubMed:25266658, ECO:0000269|PubMed:33964137}.		dorsal/ventral neural tube patterning [GO:0021904]; noradrenergic neuron development [GO:0003358]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; regulation of transcription regulatory region DNA binding [GO:2000677]	cytoplasm [GO:0005737]; nuclear lamina [GO:0005652]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	beta-catenin binding [GO:0008013]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; nuclear lamina [GO:0005652]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; beta-catenin binding [GO:0008013]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; dorsal/ventral neural tube patterning [GO:0021904]; noradrenergic neuron development [GO:0003358]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; regulation of transcription regulatory region DNA binding [GO:2000677]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:33964137}. Nucleus {ECO:0000269|PubMed:33964137}.
Q5VTD9	reviewed	GFI1B_HUMAN	Zinc finger protein Gfi-1b (Growth factor independent protein 1B) (Potential regulator of CDKN1A translocated in CML)	GFI1B	Homo sapiens (Human)	330	FUNCTION: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. {ECO:0000269|PubMed:12351384, ECO:0000269|PubMed:16177182, ECO:0000269|PubMed:16688220, ECO:0000269|PubMed:16782810, ECO:0000269|PubMed:17156408, ECO:0000269|PubMed:17272506, ECO:0000269|PubMed:17420275}.	MISCELLANEOUS: [Isoform 2]: Essential for erythroid differentiation. Binds to target gene promoters and associates with the LSD1-CoREST repressor complex more efficiently than the major isoform 1. {ECO:0000305}.	chromatin organization [GO:0006325]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; chromatin organization [GO:0006325]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16688220}.
Q5VTR2	reviewed	BRE1A_HUMAN	E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)	RNF20 BRE1A	Homo sapiens (Human)	975	FUNCTION: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19410543}.		negative regulation of cell migration [GO:0030336]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein polyubiquitination [GO:0000209]; regulation of DNA-templated transcription [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511]	HULC complex [GO:0033503]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H2B C-terminal K residue ubiquitin ligase activity [GO:0140850]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	HULC complex [GO:0033503]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H2B C-terminal K residue ubiquitin ligase activity [GO:0140850]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; negative regulation of cell migration [GO:0030336]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein polyubiquitination [GO:0000209]; regulation of DNA-templated transcription [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19037095, ECO:0000305|PubMed:16337599}.
Q5VTT2	reviewed	CFA95_HUMAN	Cilia- and flagella-associated protein 95	CFAP95 C9orf135	Homo sapiens (Human)	229	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.			axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]		axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cell membrane {ECO:0000269|PubMed:28345668}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:28345668}.
Q5VTT5	reviewed	MYOM3_HUMAN	Myomesin-3 (Myomesin family member 3)	MYOM3	Homo sapiens (Human)	1437	FUNCTION: May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}.			M band [GO:0031430]	protein homodimerization activity [GO:0042803]	M band [GO:0031430]; protein homodimerization activity [GO:0042803]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}.
Q5VTY9	reviewed	HHAT_HUMAN	Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) (Hedgehog acyltransferase) (Melanoma antigen recognized by T-cells 2) (MART-2) (Skinny hedgehog protein 1)	HHAT MART2 SKI1	Homo sapiens (Human)	493	FUNCTION: Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling (PubMed:18534984, PubMed:31875564, PubMed:24784881). It also catalyzes N-terminal palmitoylation of DHH (PubMed:24784881). Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where SHH palmitoylation occurs (PubMed:31875564). It is an essential factor for proper embryonic development and testicular organogenesis (PubMed:24784881). {ECO:0000269|PubMed:11486055, ECO:0000269|PubMed:18534984, ECO:0000269|PubMed:24784881, ECO:0000269|PubMed:31875564}.		N-terminal peptidyl-L-cysteine N-palmitoylation [GO:0018009]; smoothened signaling pathway [GO:0007224]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GTP binding [GO:0005525]; O-acyltransferase activity [GO:0008374]; palmitoyltransferase activity [GO:0016409]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; GTP binding [GO:0005525]; O-acyltransferase activity [GO:0008374]; palmitoyltransferase activity [GO:0016409]; N-terminal peptidyl-L-cysteine N-palmitoylation [GO:0018009]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25488661, ECO:0000269|PubMed:25505265, ECO:0000305|PubMed:18534984}; Multi-pass membrane protein {ECO:0000269|PubMed:25488661, ECO:0000269|PubMed:25505265}. Golgi apparatus membrane {ECO:0000305|PubMed:18534984}; Multi-pass membrane protein {ECO:0000255}. Note=Co-localizes with SHH in the ER and Golgi membrane. {ECO:0000305|PubMed:18534984}.
Q5VU43	reviewed	MYOME_HUMAN	Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein)	PDE4DIP CMYA2 KIAA0454 KIAA0477 MMGL	Homo sapiens (Human)	2346	FUNCTION: Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.	MISCELLANEOUS: [Isoform 13]: Mutagenesis at position 311-312:LP->AA (loss of MAPRE1- and MAPRE3-binding and loss of association with microtubule ends, no effect on AKAP9- and CDK5RAP2-binding, relocalizes from EB1/MAPRE1 microtubule ends to centrosomal area). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697, ECO:0000305}.	astral microtubule organization [GO:0030953]; centrosome cycle [GO:0007098]; positive regulation of microtubule nucleation [GO:0090063]; protein-containing complex assembly [GO:0065003]; regulation of Golgi organization [GO:1903358]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; myofibril [GO:0030016]; nucleus [GO:0005634]	enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; myofibril [GO:0030016]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]; astral microtubule organization [GO:0030953]; centrosome cycle [GO:0007098]; positive regulation of microtubule nucleation [GO:0090063]; protein-containing complex assembly [GO:0065003]; regulation of Golgi organization [GO:1903358]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:27666745}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9WUJ3}.; SUBCELLULAR LOCATION: [Isoform 13]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29162697}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:29162697}. Golgi apparatus {ECO:0000269|PubMed:25217626}. Note=Associated with the microtubule network at the growing distal tip of microtubules (PubMed:29162697). Targeting to the Golgi apparatus requires AKAP9 (PubMed:25217626). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:29162697}.
Q5VU57	reviewed	CBPC6_HUMAN	Cytosolic carboxypeptidase 6 (EC 3.4.17.24) (ATP/GTP-binding protein-like 4) (Protein deglutamylase CCP6)	AGBL4 CCP6	Homo sapiens (Human)	503	FUNCTION: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (By similarity). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). {ECO:0000250|UniProtKB:Q09LZ8, ECO:0000269|PubMed:29593216}.		anterograde axonal transport of mitochondrion [GO:0098957]; C-terminal protein deglutamylation [GO:0035609]; central nervous system neuron development [GO:0021954]; defense response to virus [GO:0051607]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]; regulation of blastocyst development [GO:0120222]; retrograde axonal transport of mitochondrion [GO:0098958]	axon cytoplasm [GO:1904115]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]	metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]	axon cytoplasm [GO:1904115]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]; anterograde axonal transport of mitochondrion [GO:0098957]; C-terminal protein deglutamylation [GO:0035609]; central nervous system neuron development [GO:0021954]; defense response to virus [GO:0051607]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]; regulation of blastocyst development [GO:0120222]; retrograde axonal transport of mitochondrion [GO:0098958]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09LZ8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23085998}. Golgi apparatus {ECO:0000269|PubMed:23085998}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23085998}. Note=Colocalizes with gamma-tubulin in the centrioles at interphase and dividing cells and with glutamylated tubulin in basal bodies of ciliated cells. {ECO:0000269|PubMed:23085998}.
Q5VUA4	reviewed	ZN318_HUMAN	Zinc finger protein 318 (Endocrine regulatory protein)	ZNF318 HRIHFB2436	Homo sapiens (Human)	2279	FUNCTION: [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	meiotic cell cycle [GO:0051321]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; meiotic cell cycle [GO:0051321]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9853615}.
Q5VUB5	reviewed	F1711_HUMAN	Protein FAM171A1 (Astroprincin) (APCN)	FAM171A1 APCN C10orf38	Homo sapiens (Human)	890	FUNCTION: Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}.		regulation of cell shape [GO:0008360]; stress fiber assembly [GO:0043149]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; regulation of cell shape [GO:0008360]; stress fiber assembly [GO:0043149]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30312582}; Single-pass type I membrane protein {ECO:0000305|PubMed:30312582}.
Q5VUG0	reviewed	SMBT2_HUMAN	Scm-like with four MBT domains protein 2 (Scm-like with 4 MBT domains protein 2)	SFMBT2 KIAA1617	Homo sapiens (Human)	894	FUNCTION: Transcriptional repressor of HOXB13 gene. {ECO:0000269|PubMed:23385818}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]	aggresome [GO:0016235]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; transcription corepressor activity [GO:0003714]	aggresome [GO:0016235]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; transcription corepressor activity [GO:0003714]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23385818}.
Q5VV41	reviewed	ARHGG_HUMAN	Rho guanine nucleotide exchange factor 16 (Ephexin-4)	ARHGEF16 EPHEXIN4 NBR	Homo sapiens (Human)	709	FUNCTION: Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}.		activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; positive regulation of protein localization to plasma membrane [GO:1903078]	cytosol [GO:0005829]	cadherin binding [GO:0045296]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; receptor tyrosine kinase binding [GO:0030971]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; cadherin binding [GO:0045296]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; receptor tyrosine kinase binding [GO:0030971]; small GTPase binding [GO:0031267]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; positive regulation of protein localization to plasma membrane [GO:1903078]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q5VV42	reviewed	CDKAL_HUMAN	Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase)	CDKAL1	Homo sapiens (Human)	579	FUNCTION: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000250|UniProtKB:Q91WE6}.		maintenance of translational fidelity [GO:1990145]; tRNA methylthiolation [GO:0035600]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791]	4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; N6-threonylcarbomyladenosine methylthiotransferase activity [GO:0035598]; tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase [GO:0061712]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; N6-threonylcarbomyladenosine methylthiotransferase activity [GO:0035598]; tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase [GO:0061712]; maintenance of translational fidelity [GO:1990145]; tRNA methylthiolation [GO:0035600]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23048041}; Single-pass membrane protein {ECO:0000255}. Note=Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum. {ECO:0000269|PubMed:23048041}.
Q5VV43	reviewed	K0319_HUMAN	Dyslexia-associated protein KIAA0319	KIAA0319	Homo sapiens (Human)	1072	FUNCTION: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. {ECO:0000269|PubMed:19679544}.		multicellular organismal response to stress [GO:0033555]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of dendrite development [GO:2000171]; neuron migration [GO:0001764]; positive regulation of SMAD protein signal transduction [GO:0060391]; response to auditory stimulus [GO:0010996]	clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]		clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; multicellular organismal response to stress [GO:0033555]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of dendrite development [GO:2000171]; neuron migration [GO:0001764]; positive regulation of SMAD protein signal transduction [GO:0060391]; response to auditory stimulus [GO:0010996]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18063668, ECO:0000269|PubMed:19419997}; Single-pass type I membrane protein {ECO:0000269|PubMed:18063668}. Early endosome membrane {ECO:0000269|PubMed:19419997}; Single-pass type I membrane protein {ECO:0000269|PubMed:18063668}. Note=Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted. {ECO:0000269|PubMed:18063668}.
Q5VV67	reviewed	PPRC1_HUMAN	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC)	PPRC1 KIAA0595	Homo sapiens (Human)	1664	FUNCTION: Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}.		positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11340167}. Note=Colocalizes with NRF1. {ECO:0000250}.
Q5VVJ2	reviewed	MYSM1_HUMAN	Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1)	MYSM1 KIAA1915	Homo sapiens (Human)	828	FUNCTION: Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). {ECO:0000250|UniProtKB:Q69Z66, ECO:0000269|PubMed:17707232, ECO:0000269|PubMed:22169041, ECO:0000269|PubMed:24062447, ECO:0000269|PubMed:26220525, ECO:0000269|PubMed:28115216, ECO:0000269|PubMed:33086059}.		chromatin remodeling [GO:0006338]; immune system process [GO:0002376]; pigmentation [GO:0043473]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteolysis [GO:0006508]; regulation of cell migration [GO:0030334]; regulation of hair follicle development [GO:0051797]; regulation of hemopoiesis [GO:1903706]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA binding [GO:0003677]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; transcription coactivator activity [GO:0003713]; chromatin remodeling [GO:0006338]; immune system process [GO:0002376]; pigmentation [GO:0043473]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteolysis [GO:0006508]; regulation of cell migration [GO:0030334]; regulation of hair follicle development [GO:0051797]; regulation of hemopoiesis [GO:1903706]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:17707232}. Cytoplasm {ECO:0000250|UniProtKB:Q69Z66}. Note=Localizes to the cytoplasm in response to bacterial infection. {ECO:0000250|UniProtKB:Q69Z66}.
Q5VVQ6	reviewed	OTU1_HUMAN	Ubiquitin thioesterase OTU1 (EC 3.4.19.12) (DUBA-8) (HIV-1-induced protease 7) (HIN-7) (HsHIN7) (OTU domain-containing protein 2)	YOD1 DUBA8 HIN7 OTUD2 PRO0907	Homo sapiens (Human)	348	FUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622). {ECO:0000269|PubMed:19818707, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:27753622}.		endoplasmic reticulum unfolded protein response [GO:0030968]; macroautophagy [GO:0016236]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein K11-linked deubiquitination [GO:0035871]; protein K27-linked deubiquitination [GO:1990167]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; ubiquitin protein ligase binding [GO:0031625]; endoplasmic reticulum unfolded protein response [GO:0030968]; macroautophagy [GO:0016236]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein K11-linked deubiquitination [GO:0035871]; protein K27-linked deubiquitination [GO:1990167]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27753622}. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. {ECO:0000269|PubMed:27753622}.
Q5VVX9	reviewed	UBE2U_HUMAN	Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)	UBE2U	Homo sapiens (Human)	321	FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins. {ECO:0000269|PubMed:22496338}.		protein ubiquitination [GO:0016567]		ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; protein ubiquitination [GO:0016567]	
Q5VVY1	reviewed	NTM1B_HUMAN	N-terminal Xaa-Pro-Lys N-methyltransferase 2 (EC 2.1.1.299) (Alpha N-terminal protein methyltransferase 1B) (Methyltransferase-like protein 11B) (X-Pro-Lys N-terminal protein methyltransferase 1B) (NTM1B)	NTMT2 C1orf184 METTL11B NRMT2	Homo sapiens (Human)	283	FUNCTION: Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif (PubMed:24090352, PubMed:30417120). Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro) (PubMed:30417120). May activate NTMT1 by priming its substrates for trimethylation (PubMed:24090352). {ECO:0000269|PubMed:24090352, ECO:0000269|PubMed:30417120}.		N-terminal protein amino acid methylation [GO:0006480]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	N-terminal protein N-methyltransferase activity [GO:0071885]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; N-terminal protein N-methyltransferase activity [GO:0071885]; N-terminal protein amino acid methylation [GO:0006480]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24090352}.
Q5VW32	reviewed	BROX_HUMAN	BRO1 domain-containing protein BROX (BRO1 domain- and CAAX motif-containing protein)	BROX BROFTI C1orf58	Homo sapiens (Human)	411	FUNCTION: Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane. {ECO:0000269|PubMed:34818527}.		mitotic nuclear membrane reassembly [GO:0007084]	extracellular exosome [GO:0070062]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]		extracellular exosome [GO:0070062]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; mitotic nuclear membrane reassembly [GO:0007084]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000305|PubMed:34818527}; Lipid-anchor {ECO:0000305|PubMed:18190528}. Note=During nuclear envelope repair, localizes at rupture sites where it is recruited by the CHMP7/ESCRT-III axis. {ECO:0000269|PubMed:34818527}.
Q5VW36	reviewed	FOCAD_HUMAN	Focadhesin	FOCAD KIAA1797	Homo sapiens (Human)	1801	FUNCTION: Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver. May be involved in the regulation of RNA degradation by the exosome complex (PubMed:35864190). Potential tumor suppressor in gliomas. {ECO:0000250, ECO:0000269|PubMed:22427331, ECO:0000269|PubMed:35864190}.		regulation of post-transcriptional gene silencing [GO:0060147]	cytosol [GO:0005829]; focal adhesion [GO:0005925]		cytosol [GO:0005829]; focal adhesion [GO:0005925]; regulation of post-transcriptional gene silencing [GO:0060147]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:22427331}. Cytoplasm, cytosol {ECO:0000269|PubMed:35864190}. Note=In astrocytes, colocalizes with VCL to the end of actin stress fibers, which normally terminate at focal adhesions. In hepatocytes, it is found in the cytosol. {ECO:0000269|PubMed:22427331, ECO:0000269|PubMed:35864190}.
Q5VW38	reviewed	GP107_HUMAN	Protein GPR107 (Lung seven transmembrane receptor 1)	GPR107 KIAA1624 LUSTR1	Homo sapiens (Human)	600	FUNCTION: Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). {ECO:0000250|UniProtKB:D3ZWZ9, ECO:0000269|PubMed:22933024}.; FUNCTION: (Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum. {ECO:0000269|PubMed:25031321}.		clathrin-dependent endocytosis [GO:0072583]	clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	clathrin heavy chain binding [GO:0032050]	clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; clathrin heavy chain binding [GO:0032050]; clathrin-dependent endocytosis [GO:0072583]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:D3ZWZ9}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:25031321}.
Q5VWC8	reviewed	HACD4_HUMAN	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 4) (HACD4) (Protein-tyrosine phosphatase-like A domain-containing protein 2)	HACD4 PTPLAD2	Homo sapiens (Human)	232	FUNCTION: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.		fatty acid elongation [GO:0030497]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; fatty acid elongation [GO:0030497]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}.
Q5VWG9	reviewed	TAF3_HUMAN	Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140)	TAF3	Homo sapiens (Human)	929	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666). {ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:33795473}.		maintenance of protein location in nucleus [GO:0051457]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	male germ cell nucleus [GO:0001673]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]	metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription regulator inhibitor activity [GO:0140416]	male germ cell nucleus [GO:0001673]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription regulator inhibitor activity [GO:0140416]; maintenance of protein location in nucleus [GO:0051457]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11438666}.
Q5VWJ9	reviewed	SNX30_HUMAN	Sorting nexin-30	SNX30	Homo sapiens (Human)	437	FUNCTION: Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:32513819). Together with SNX4, involved in autophagosome assembly (PubMed:32513819). {ECO:0000269|PubMed:32513819}.		autophagy of mitochondrion [GO:0000422]; endocytic recycling [GO:0032456]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; protein transport [GO:0015031]; reticulophagy [GO:0061709]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; phagophore assembly site [GO:0000407]	phosphatidylinositol binding [GO:0035091]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; phagophore assembly site [GO:0000407]; phosphatidylinositol binding [GO:0035091]; autophagy of mitochondrion [GO:0000422]; endocytic recycling [GO:0032456]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; protein transport [GO:0015031]; reticulophagy [GO:0061709]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:32513819}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95219}; Cytoplasmic side {ECO:0000250|UniProtKB:O95219}.
Q5VWK5	reviewed	IL23R_HUMAN	Interleukin-23 receptor (IL-23 receptor) (IL-23R)	IL23R	Homo sapiens (Human)	629	FUNCTION: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. {ECO:0000269|PubMed:12023369}.	MISCELLANEOUS: [Isoform 2]: Produced by translation in an alternate frame of the cDNA encoding isoform 4. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by translation in an alternate frame of the cDNA encoding isoform 5. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by translation in an alternate frame of the cDNA encoding isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by translation in an alternate frame of the cDNA encoding isoform 3. {ECO:0000305}.	cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; inflammatory response [GO:0006954]; interleukin-23-mediated signaling pathway [GO:0038155]; negative regulation of interleukin-10 production [GO:0032693]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]; response to lipopolysaccharide [GO:0032496]; response to type II interferon [GO:0034341]	external side of plasma membrane [GO:0009897]; interleukin-23 receptor complex [GO:0072536]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]	external side of plasma membrane [GO:0009897]; interleukin-23 receptor complex [GO:0072536]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; inflammatory response [GO:0006954]; interleukin-23-mediated signaling pathway [GO:0038155]; negative regulation of interleukin-10 production [GO:0032693]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]; response to lipopolysaccharide [GO:0032496]; response to type II interferon [GO:0034341]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12023369}; Single-pass type I membrane protein {ECO:0000269|PubMed:12023369}.
Q5VWN6	reviewed	TASO2_HUMAN	Protein TASOR 2	TASOR2 C10orf18 FAM208B KIAA2006	Homo sapiens (Human)	2430			negative regulation of gene expression, epigenetic [GO:0045814]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; negative regulation of gene expression, epigenetic [GO:0045814]	
Q5VWP2	reviewed	TET5C_HUMAN	Terminal nucleotidyltransferase 5C (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46C)	TENT5C FAM46C	Homo sapiens (Human)	391	FUNCTION: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression (PubMed:32009146, PubMed:28931820, PubMed:34048638). Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich (PubMed:34048638). Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein (PubMed:28931820). {ECO:0000269|PubMed:28931820, ECO:0000269|PubMed:32009146, ECO:0000269|PubMed:34048638}.; FUNCTION: (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon. {ECO:0000269|PubMed:21478870}.		in utero embryonic development [GO:0001701]; mRNA stabilization [GO:0048255]; negative regulation of cell differentiation [GO:0045596]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; in utero embryonic development [GO:0001701]; mRNA stabilization [GO:0048255]; negative regulation of cell differentiation [GO:0045596]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28931820}. Cytoplasm {ECO:0000269|PubMed:28931820}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:32433990}. Note=Recruited into the centrosome through its interaction with PLK4. {ECO:0000269|PubMed:32433990}.
Q5VWP3	reviewed	MLIP_HUMAN	Muscular LMNA-interacting protein (Cardiac Isl1-interacting protein) (CIP) (Muscular-enriched A-type laminin-interacting protein)	MLIP C6orf142 Cip	Homo sapiens (Human)	993	FUNCTION: Required for myoblast differentiation into myotubes, possibly acting as a transcriptional regulator of the myogenic program (By similarity). Required for cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays a role in the protection against cardiac hypertrophy (By similarity). Binds chromatin (By similarity). May act as a transcriptional cofactor for ISL1, repressing its transcriptional activity (By similarity). May also repress MYOCD transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q5FW52}.	MISCELLANEOUS: It is uncertain whether Met-1 or Met-18 is the initiator. {ECO:0000305}.	negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear lumen [GO:0031981]; nucleus [GO:0005634]; PML body [GO:0016605]; sarcolemma [GO:0042383]		cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear lumen [GO:0031981]; nucleus [GO:0005634]; PML body [GO:0016605]; sarcolemma [GO:0042383]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34581780}. Nucleus envelope {ECO:0000250|UniProtKB:Q5FW52}. Nucleus, PML body {ECO:0000250|UniProtKB:Q5FW52}. Cytoplasm, cytosol {ECO:0000269|PubMed:34581780}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q5FW52}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q5FW52}; Cytoplasmic side {ECO:0000250|UniProtKB:Q5FW52}.
Q5VWQ8	reviewed	DAB2P_HUMAN	Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein)	DAB2IP AF9Q34 AIP1 KIAA1743	Homo sapiens (Human)	1189	FUNCTION: Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229}.	MISCELLANEOUS: The DAB2IP gene is found epigenetically silenced in numerous aggressive cancers, like prostate cancers and medulloblastoma tumors. Epigenetic suppression of DAB2IP by EZH2 is a major mechanism of DAB2IP inactivation in human prostate cancer and increases metastatic potential (PubMed:20154697, PubMed:22696229). {ECO:0000305|PubMed:20154697, ECO:0000305|PubMed:22696229}.	angiogenesis [GO:0001525]; cell cycle [GO:0007049]; cell motility involved in cerebral cortex radial glia guided migration [GO:0021814]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to unfolded protein [GO:0034620]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial cell apoptotic process [GO:0072577]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; I-kappaB phosphorylation [GO:0007252]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; layer formation in cerebral cortex [GO:0021819]; negative regulation of angiogenesis [GO:0016525]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of GTPase activity [GO:0034260]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; neuron projection morphogenesis [GO:0048812]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of dendrite development [GO:1900006]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of synapse maturation [GO:0090129]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein catabolic process [GO:0030163]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cell cycle [GO:0051726]; regulation of GTPase activity [GO:0043087]; regulation of p38MAPK cascade [GO:1900744]; regulation of protein-containing complex assembly [GO:0043254]; tube formation [GO:0035148]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]	AIP1-IRE1 complex [GO:1990597]; axon [GO:0030424]; cerebellar mossy fiber [GO:0044300]; climbing fiber [GO:0044301]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endocytic vesicle [GO:0030139]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; parallel fiber [GO:1990032]; plasma membrane [GO:0005886]	14-3-3 protein binding [GO:0071889]; cadherin binding [GO:0045296]; death receptor binding [GO:0005123]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; mitogen-activated protein kinase kinase binding [GO:0031434]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein serine/threonine kinase activator activity [GO:0043539]; protein-containing complex binding [GO:0044877]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; vascular endothelial growth factor receptor 2 binding [GO:0043184]	AIP1-IRE1 complex [GO:1990597]; axon [GO:0030424]; cerebellar mossy fiber [GO:0044300]; climbing fiber [GO:0044301]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endocytic vesicle [GO:0030139]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; parallel fiber [GO:1990032]; plasma membrane [GO:0005886]; 14-3-3 protein binding [GO:0071889]; cadherin binding [GO:0045296]; death receptor binding [GO:0005123]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; mitogen-activated protein kinase kinase binding [GO:0031434]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein serine/threonine kinase activator activity [GO:0043539]; protein-containing complex binding [GO:0044877]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; angiogenesis [GO:0001525]; cell cycle [GO:0007049]; cell motility involved in cerebral cortex radial glia guided migration [GO:0021814]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to unfolded protein [GO:0034620]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial cell apoptotic process [GO:0072577]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; I-kappaB phosphorylation [GO:0007252]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; layer formation in cerebral cortex [GO:0021819]; negative regulation of angiogenesis [GO:0016525]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of GTPase activity [GO:0034260]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; neuron projection morphogenesis [GO:0048812]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of dendrite development [GO:1900006]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of synapse maturation [GO:0090129]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein catabolic process [GO:0030163]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cell cycle [GO:0051726]; regulation of GTPase activity [GO:0043087]; regulation of p38MAPK cascade [GO:1900744]; regulation of protein-containing complex assembly [GO:0043254]; tube formation [GO:0035148]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Membrane. Cell projection, dendrite {ECO:0000250}. Note=Localized in soma and dendrites of Purkinje cells as well as in scattered cell bodies in the molecular layer of the cerebellum (By similarity). Colocalizes with TIRAP at the plasma membrane. Colocalizes with ARF6 at the plasma membrane and endocytic vesicles. Translocates from the plasma membrane to the cytoplasm in response to TNF-alpha. Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for plasma membrane localization. {ECO:0000250}.
Q5VWT5	reviewed	FYB2_HUMAN	FYN-binding protein 2 (Activation-dependent, raft-recruited ADAP-like phosphoprotein)	FYB2 ARAP C1orf168	Homo sapiens (Human)	728	FUNCTION: Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation (PubMed:27335501). {ECO:0000269|PubMed:27335501}.		cell adhesion mediated by integrin [GO:0033627]; integrin-mediated signaling pathway [GO:0007229]; protein localization to plasma membrane [GO:0072659]; T cell receptor signaling pathway [GO:0050852]	immunological synapse [GO:0001772]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]		immunological synapse [GO:0001772]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; cell adhesion mediated by integrin [GO:0033627]; integrin-mediated signaling pathway [GO:0007229]; protein localization to plasma membrane [GO:0072659]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane raft {ECO:0000269|PubMed:27335501}. Note=Recruited to membrane rafts and immunological synapse after TCR stimulation. {ECO:0000269|PubMed:27335501}.
Q5VWX1	reviewed	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Sam68-like mammalian protein 1) (SLM-1) (hSLM-1)	KHDRBS2 SLM1	Homo sapiens (Human)	349	FUNCTION: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis. {ECO:0000250|UniProtKB:Q920F3, ECO:0000250|UniProtKB:Q9WU01}.		mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9WU01}.
Q5VWZ2	reviewed	LYPL1_HUMAN	Lysophospholipase-like protein 1 (EC 3.1.2.22)	LYPLAL1	Homo sapiens (Human)	237	FUNCTION: Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. {ECO:0000269|PubMed:22052940, ECO:0000269|PubMed:22399288}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site. {ECO:0000305}.		cytoplasm [GO:0005737]; cytosol [GO:0005829]	carboxylic ester hydrolase activity [GO:0052689]; hydrolase activity, acting on ester bonds [GO:0016788]; lysophospholipase activity [GO:0004622]; palmitoyl-(protein) hydrolase activity [GO:0008474]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; carboxylic ester hydrolase activity [GO:0052689]; hydrolase activity, acting on ester bonds [GO:0016788]; lysophospholipase activity [GO:0004622]; palmitoyl-(protein) hydrolase activity [GO:0008474]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:22399288}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:22399288}.
Q5VX71	reviewed	SUSD4_HUMAN	Sushi domain-containing protein 4	SUSD4 UNQ196/PRO222	Homo sapiens (Human)	490	FUNCTION: Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. {ECO:0000269|PubMed:23482636}.		complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, alternative pathway [GO:0045957]; negative regulation of complement activation, classical pathway [GO:0045959]; regulation of complement activation [GO:0030449]	extracellular region [GO:0005576]; membrane [GO:0016020]		extracellular region [GO:0005576]; membrane [GO:0016020]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, alternative pathway [GO:0045957]; negative regulation of complement activation, classical pathway [GO:0045959]; regulation of complement activation [GO:0030449]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305|PubMed:23482636}.
Q5VXI9	reviewed	LIPN_HUMAN	Lipase member N (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 4)	LIPN LIPL4	Homo sapiens (Human)	398	FUNCTION: Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. {ECO:0000269|PubMed:17562024}.		cornification [GO:0070268]; lipid catabolic process [GO:0016042]	extracellular region [GO:0005576]	lipoprotein lipase activity [GO:0004465]	extracellular region [GO:0005576]; lipoprotein lipase activity [GO:0004465]; cornification [GO:0070268]; lipid catabolic process [GO:0016042]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5VXU9	reviewed	SHOC1_HUMAN	Protein shortage in chiasmata 1 ortholog (EC 3.6.-.-) (Protein ZIP2 homolog) (MZIP2)	SHOC1 C9orf84 ZIP2	Homo sapiens (Human)	1444	FUNCTION: ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (PubMed:29742103). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (PubMed:29742103). Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (By similarity). Required for proper synaptonemal complex assembly and homologous chromosome pairing (By similarity). Requiref for recruitment TEX11 and MSH4 to recombination intermediates (By similarity). {ECO:0000250|UniProtKB:A2ALV5, ECO:0000269|PubMed:29742103}.		reciprocal meiotic recombination [GO:0007131]; resolution of meiotic recombination intermediates [GO:0000712]; synaptonemal complex assembly [GO:0007130]	chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]	ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]; reciprocal meiotic recombination [GO:0007131]; resolution of meiotic recombination intermediates [GO:0000712]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:A2ALV5}. Note=Localizes to meiotic chromosomes; associates with mid-stage meiotic recombination intermediates. Localization requires meiotic double-strand breaks (DSBs) recombination intermediates catalyzed by DMC1. {ECO:0000250|UniProtKB:A2ALV5}.
Q5VY09	reviewed	IER5_HUMAN	Immediate early response gene 5 protein	IER5 PP4583 SBBI48	Homo sapiens (Human)	327	FUNCTION: Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193). {ECO:0000269|PubMed:19238419, ECO:0000269|PubMed:22132193, ECO:0000269|PubMed:25355627, ECO:0000269|PubMed:25816751, ECO:0000269|PubMed:26496226}.		cellular response to heat [GO:0034605]; positive regulation of cellular response to heat [GO:1900036]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; cellular response to heat [GO:0034605]; positive regulation of cellular response to heat [GO:1900036]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25816751}. Cytoplasm {ECO:0000269|PubMed:25816751}. Note=Predominantly cytoplasmic (PubMed:25816751). Translocated in the nucleus during heat shock (PubMed:25816751). {ECO:0000269|PubMed:25816751}.
Q5VY43	reviewed	PEAR1_HUMAN	Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12)	PEAR1 MEGF12	Homo sapiens (Human)	1037	FUNCTION: When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. {ECO:0000250}.		phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet aggregation [GO:0070527]; recognition of apoptotic cell [GO:0043654]	membrane [GO:0016020]; phagocytic cup [GO:0001891]	signaling receptor activity [GO:0038023]	membrane [GO:0016020]; phagocytic cup [GO:0001891]; signaling receptor activity [GO:0038023]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet aggregation [GO:0070527]; recognition of apoptotic cell [GO:0043654]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Detected on the cell surface in resting platelets. {ECO:0000269|PubMed:15851471}.
Q5VY80	reviewed	ULBP6_HUMAN	UL16-binding protein 6 (Retinoic acid early transcript 1L protein)	RAET1L ULBP6	Homo sapiens (Human)	246	FUNCTION: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. {ECO:0000269|PubMed:19658097, ECO:0000269|PubMed:28559451}.	MISCELLANEOUS: UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain.	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]		endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19658097}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19658097}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9BZM6}. Note=In CMV-infected fibroblasts, detected intracellularly. {ECO:0000269|PubMed:19658097}.
Q5VYJ5	reviewed	MALR1_HUMAN	MAM and LDL-receptor class A domain-containing protein 1	MALRD1 C10orf112 DIET1	Homo sapiens (Human)	2156	FUNCTION: Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis. {ECO:0000269|PubMed:23747249}.		cholesterol homeostasis [GO:0042632]; negative regulation of bile acid biosynthetic process [GO:0070858]	cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794]		cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794]; cholesterol homeostasis [GO:0042632]; negative regulation of bile acid biosynthetic process [GO:0070858]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:A2AJX4}; Single-pass type I membrane protein {ECO:0000255}.
Q5VYK3	reviewed	ECM29_HUMAN	Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog)	ECPAS ECM29 KIAA0368	Homo sapiens (Human)	1845	FUNCTION: Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q6PDI5, ECO:0000269|PubMed:15496406, ECO:0000269|PubMed:20682791}.		proteasome assembly [GO:0043248]; ubiquitin-dependent ERAD pathway [GO:0030433]	centrosome [GO:0005813]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; late endosome [GO:0005770]; membrane [GO:0016020]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]	molecular adaptor activity [GO:0060090]; proteasome binding [GO:0070628]	centrosome [GO:0005813]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; late endosome [GO:0005770]; membrane [GO:0016020]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; molecular adaptor activity [GO:0060090]; proteasome binding [GO:0070628]; proteasome assembly [GO:0043248]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:15496406}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:15496406}. Endosome {ECO:0000269|PubMed:15496406}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15496406}. Nucleus {ECO:0000269|PubMed:15496406}. Endosome, multivesicular body {ECO:0000269|PubMed:20682791}. Cytoplasmic vesicle {ECO:0000269|PubMed:20682791}.
Q5VYS8	reviewed	TUT7_HUMAN	Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6)	TUT7 HS2 KIAA1711 ZCCHC6	Homo sapiens (Human)	1495	FUNCTION: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:19703396, PubMed:22898984, PubMed:18172165, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}.		miRNA metabolic process [GO:0010586]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; oocyte maturation [GO:0001556]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; pre-miRNA processing [GO:0031054]; retrotransposon silencing by mRNA destabilization [GO:0141008]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; uridylyltransferase activity [GO:0070569]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; uridylyltransferase activity [GO:0070569]; zinc ion binding [GO:0008270]; miRNA metabolic process [GO:0010586]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; oocyte maturation [GO:0001556]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; pre-miRNA processing [GO:0031054]; retrotransposon silencing by mRNA destabilization [GO:0141008]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:30122351}. Note=Expression is pancytoplasmic in contrast with TUT4 expression which is enriched in cytoplasmic ribonucleoprotein granules. {ECO:0000269|PubMed:30122351}.
Q5VYX0	reviewed	RNLS_HUMAN	Renalase (EC 1.6.3.5) (Monoamine oxidase-C) (MAO-C)	RNLS C10orf59	Homo sapiens (Human)	342	FUNCTION: Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. {ECO:0000269|PubMed:15841207, ECO:0000269|PubMed:17385068, ECO:0000269|PubMed:25531177}.		negative regulation of blood pressure [GO:0045776]; negative regulation of heart rate [GO:0010459]; response to epinephrine [GO:0071871]; response to ischemia [GO:0002931]; response to salt [GO:1902074]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	epinephrine binding [GO:0051379]; monoamine oxidase activity [GO:0097621]; NADH binding [GO:0070404]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; epinephrine binding [GO:0051379]; monoamine oxidase activity [GO:0097621]; NADH binding [GO:0070404]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]; negative regulation of blood pressure [GO:0045776]; negative regulation of heart rate [GO:0010459]; response to epinephrine [GO:0071871]; response to ischemia [GO:0002931]; response to salt [GO:1902074]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15841207}.
Q5VZ89	reviewed	DEN4C_HUMAN	DENN domain-containing protein 4C	DENND4C C9orf55 C9orf55B	Homo sapiens (Human)	1909	FUNCTION: Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}.		cellular response to insulin stimulus [GO:0032869]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of Rab protein signal transduction [GO:0032483]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; insulin-responsive compartment [GO:0032593]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; retromer complex [GO:0030904]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; insulin-responsive compartment [GO:0032593]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; retromer complex [GO:0030904]; guanyl-nucleotide exchange factor activity [GO:0005085]; cellular response to insulin stimulus [GO:0032869]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of Rab protein signal transduction [GO:0032483]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with SLC2A4/GLUT4 storage vesicles.
Q5VZE5	reviewed	NAA35_HUMAN	N-alpha-acetyltransferase 35, NatC auxiliary subunit (Embryonic growth-associated protein homolog) (Protein MAK10 homolog)	NAA35 EGAP MAK10	Homo sapiens (Human)	725	FUNCTION: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells. {ECO:0000269|PubMed:19398576}.		negative regulation of apoptotic process [GO:0043066]; smooth muscle cell proliferation [GO:0048659]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatC complex [GO:0031417]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatC complex [GO:0031417]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; negative regulation of apoptotic process [GO:0043066]; smooth muscle cell proliferation [GO:0048659]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19398576}.
Q5VZF2	reviewed	MBNL2_HUMAN	Muscleblind-like protein 2 (Muscleblind-like protein 1) (Muscleblind-like protein-like) (Muscleblind-like protein-like 39)	MBNL2 MBLL MBLL39 MLP1	Homo sapiens (Human)	373	FUNCTION: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). {ECO:0000269|PubMed:15257297, ECO:0000269|PubMed:16273094, ECO:0000269|PubMed:16946708}.		mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11929853}. Cytoplasm {ECO:0000269|PubMed:16273094}. Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques (PubMed:16273094). Location in the cytoplasm is microtubule-dependent (PubMed:16273094). In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts (PubMed:11929853).
Q5VZK9	reviewed	CARL1_HUMAN	F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)	CARMIL1 CARMIL LRRC16 LRRC16A	Homo sapiens (Human)	1371	FUNCTION: Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}.		actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; barbed-end actin filament uncapping [GO:0051638]; cell migration [GO:0016477]; lamellipodium assembly [GO:0030032]; macropinocytosis [GO:0044351]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; urate metabolic process [GO:0046415]	cell leading edge [GO:0031252]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; lamellipodium [GO:0030027]; macropinosome [GO:0044354]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	protein-containing complex binding [GO:0044877]	cell leading edge [GO:0031252]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; lamellipodium [GO:0030027]; macropinosome [GO:0044354]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex binding [GO:0044877]; actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; barbed-end actin filament uncapping [GO:0051638]; cell migration [GO:0016477]; lamellipodium assembly [GO:0030032]; macropinocytosis [GO:0044351]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; urate metabolic process [GO:0046415]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19846667}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6EDY6}. Cell membrane {ECO:0000269|PubMed:26578515}. Cell projection, lamellipodium {ECO:0000269|PubMed:19846667}. Note=Found on macropinosomes (PubMed:19846667). Colocalized with heterodimeric capping protein (CP) and F-actin in lamellipodia but not with F-actin in stress fibers (PubMed:19846667). {ECO:0000269|PubMed:19846667}.
Q5VZL5	reviewed	ZMYM4_HUMAN	Zinc finger MYM-type protein 4 (Zinc finger protein 262)	ZMYM4 KIAA0425 ZNF262	Homo sapiens (Human)	1548	FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.	MISCELLANEOUS: The 3'-UTR region of the mRNA encoding this protein contains a motif called CDIR (for cell death inhibiting RNA) that binds HNRPD/AUF1 and HSPB1/HSP27. It is able to inhibit interferon-gamma induced apoptosis.	cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]		DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]	
Q5VZM2	reviewed	RRAGB_HUMAN	Ras-related GTP-binding protein B (Rag B) (RagB) (EC 3.6.5.-)	RRAGB	Homo sapiens (Human)	374	FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:18497260, PubMed:20381137, PubMed:23723238, PubMed:24095279). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagB/RRAGB is in its active form when GTP-bound RagB/RRAGB forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagB/RRAGB heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed:18497260, PubMed:20381137, PubMed:23723238, PubMed:24095279). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:18497260, PubMed:20381137, PubMed:23723238). Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008). {ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:9394008}.		cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to leucine starvation [GO:1990253]; cellular response to starvation [GO:0009267]; negative regulation of autophagy [GO:0010507]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; regulation of TOR signaling [GO:0032006]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gtr1-Gtr2 GTPase complex [GO:1990131]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; guanyl ribonucleotide binding [GO:0032561]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gtr1-Gtr2 GTPase complex [GO:1990131]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; guanyl ribonucleotide binding [GO:0032561]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to leucine starvation [GO:1990253]; cellular response to starvation [GO:0009267]; negative regulation of autophagy [GO:0010507]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; regulation of TOR signaling [GO:0032006]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9394008}. Lysosome membrane {ECO:0000269|PubMed:20381137}. Note=Recruited to the lysosome surface by the Ragulator complex. {ECO:0000269|PubMed:20381137}.
Q5VZV1	reviewed	MT21C_HUMAN	Protein-lysine methyltransferase METTL21C (EC 2.1.1.-) (Methyltransferase-like protein 21C)	METTL21C C13orf39	Homo sapiens (Human)	264	FUNCTION: Protein-lysine methyltransferase. {ECO:0000269|PubMed:22948820}.		cellular response to dexamethasone stimulus [GO:0071549]; hormone-mediated apoptotic signaling pathway [GO:0008628]; peptidyl-lysine methylation [GO:0018022]; protein methylation [GO:0006479]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; skeletal muscle tissue development [GO:0007519]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	heat shock protein binding [GO:0031072]; protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; heat shock protein binding [GO:0031072]; protein-lysine N-methyltransferase activity [GO:0016279]; cellular response to dexamethasone stimulus [GO:0071549]; hormone-mediated apoptotic signaling pathway [GO:0008628]; peptidyl-lysine methylation [GO:0018022]; protein methylation [GO:0006479]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23349634}.
Q5VZY2	reviewed	PLPP4_HUMAN	Phospholipid phosphatase 4 (EC 3.1.3.4) (EC 3.6.1.75) (Phosphatidic acid phosphatase type 2 domain-containing protein 1A)	PLPP4 DPPL2 PPAPDC1 PPAPDC1A	Homo sapiens (Human)	271	FUNCTION: Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol (PubMed:28851360). {ECO:0000269|PubMed:17590538, ECO:0000269|PubMed:28851360}.		blastocyst hatching [GO:0001835]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; regulation of calcium ion import [GO:0090279]	plasma membrane [GO:0005886]	diacylglycerol diphosphate phosphatase activity [GO:0000810]; identical protein binding [GO:0042802]; phosphatidate phosphatase activity [GO:0008195]	plasma membrane [GO:0005886]; diacylglycerol diphosphate phosphatase activity [GO:0000810]; identical protein binding [GO:0042802]; phosphatidate phosphatase activity [GO:0008195]; blastocyst hatching [GO:0001835]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; regulation of calcium ion import [GO:0090279]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:17590538}; Multi-pass membrane protein {ECO:0000255}.
Q5W0B1	reviewed	OBI1_HUMAN	ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219)	OBI1 C13orf7 RNF219	Homo sapiens (Human)	726	FUNCTION: E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}.		protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; regulation of DNA replication [GO:0006275]	chromatin [GO:0000785]	chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]	chromatin [GO:0000785]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; regulation of DNA replication [GO:0006275]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:31160578}. Note=Association to chromatin is cell cycle-regulated, absent from mitotic chromosomes, is associated with chromatin from G1 and partially released from chromatin from mid S-phase. {ECO:0000269|PubMed:31160578}.
Q5W0Q7	reviewed	USPL1_HUMAN	SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1)	USPL1 C13orf22 D13S106	Homo sapiens (Human)	1092	FUNCTION: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}.		Cajal body organization [GO:0030576]; cell population proliferation [GO:0008283]; protein desumoylation [GO:0016926]; snRNA transcription [GO:0009301]	Cajal body [GO:0015030]; extracellular space [GO:0005615]	deSUMOylase activity [GO:0016929]; SUMO binding [GO:0032183]	Cajal body [GO:0015030]; extracellular space [GO:0005615]; deSUMOylase activity [GO:0016929]; SUMO binding [GO:0032183]; Cajal body organization [GO:0030576]; cell population proliferation [GO:0008283]; protein desumoylation [GO:0016926]; snRNA transcription [GO:0009301]	SUBCELLULAR LOCATION: Nucleus, Cajal body {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}.
Q5W0Z9	reviewed	ZDH20_HUMAN	Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20)	ZDHHC20	Homo sapiens (Human)	365	FUNCTION: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:27153536, PubMed:29326245, PubMed:33219126). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation (PubMed:27153536). Has a preference for acyl-CoA with C16 fatty acid chains (PubMed:29326245). Can also utilize acyl-CoA with C14 and C18 fatty acid chains (PubMed:29326245). {ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:29326245, ECO:0000269|PubMed:33219126}.; FUNCTION: (Microbial infection) Dominant palmitoyltransferase responsible for lipidation of SARS coronavirus-2/SARS-CoV-2 spike protein. Through a sequential action with ZDHHC9, rapidly and efficiently palmitoylates spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}.		peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation by host of viral process [GO:0044794]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; synaptic vesicle maturation [GO:0016188]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; zinc ion binding [GO:0008270]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation by host of viral process [GO:0044794]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; synaptic vesicle maturation [GO:0016188]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:29326245}; Multi-pass membrane protein {ECO:0000269|PubMed:29326245}. Cell membrane {ECO:0000269|PubMed:27153536}; Multi-pass membrane protein {ECO:0000269|PubMed:29326245}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27153536}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:34599882}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000305|PubMed:34599882}; Multi-pass membrane protein {ECO:0000255}.
Q5W111	reviewed	SPRY7_HUMAN	SPRY domain-containing protein 7 (Chronic lymphocytic leukemia deletion region gene 6 protein) (CLL deletion region gene 6 protein)	SPRYD7 C13orf1 CLLD6	Homo sapiens (Human)	196							
Q5W5X9	reviewed	TTC23_HUMAN	Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8)	TTC23 HCC8	Homo sapiens (Human)	447	FUNCTION: Participates positively in the ciliary Hedgehog (Hh) signaling. {ECO:0000250|UniProtKB:Q8CHY7}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	positive regulation of smoothened signaling pathway [GO:0045880]	cilium [GO:0005929]		cilium [GO:0005929]; positive regulation of smoothened signaling pathway [GO:0045880]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q8CHY7}. Note=Colocalizes with EVC and IQCE at the EvC zone of primary cilia. {ECO:0000250|UniProtKB:Q8CHY7}.
Q5XG87	reviewed	PAPD7_HUMAN	Terminal nucleotidyltransferase 4A (DNA polymerase sigma) (LAK-1) (Non-canonical poly(A) RNA polymerase PAPD7) (EC 2.7.7.19) (PAP-associated domain-containing protein 7) (TRAMP-like complex polyadenylate polymerase) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 5) (TUTase 5) (Topoisomerase-related function protein 4-1) (TRF4-1)	TENT4A PAPD7 POLS TRF4	Homo sapiens (Human)	792	FUNCTION: Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078). {ECO:0000269|PubMed:23376078, ECO:0000269|PubMed:30026317}.	MISCELLANEOUS: [Isoform 2]: Exhibits poor nucleotidyl transferase activity. {ECO:0000305}.	double-strand break repair [GO:0006302]; mitotic chromosome condensation [GO:0007076]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; response to xenobiotic stimulus [GO:0009410]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; sister chromatid cohesion [GO:0007062]	Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499]	ATP binding [GO:0005524]; guanylyltransferase activity [GO:0070568]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; SMC family protein binding [GO:0043221]	Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499]; ATP binding [GO:0005524]; guanylyltransferase activity [GO:0070568]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; SMC family protein binding [GO:0043221]; double-strand break repair [GO:0006302]; mitotic chromosome condensation [GO:0007076]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; response to xenobiotic stimulus [GO:0009410]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; sister chromatid cohesion [GO:0007062]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23376078}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23376078}. Note=Excluded from nucleolus, weak staining detected in the cytoplasm. {ECO:0000269|PubMed:23376078}.
Q5XKE5	reviewed	K2C79_HUMAN	Keratin, type II cytoskeletal 79 (Cytokeratin-79) (CK-79) (Keratin-6-like) (Keratin-6L) (Keratin-79) (K79) (Type-II keratin Kb38)	KRT79 K6L KB38 KRT6L	Homo sapiens (Human)	535		MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]	enzyme binding [GO:0019899]; structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; enzyme binding [GO:0019899]; structural constituent of skin epidermis [GO:0030280]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
Q5XKL5	reviewed	BTBD8_HUMAN	BTB/POZ domain-containing protein 8 (AP2-interacting clathrin-endocytosis) (APache)	BTBD8 KIAA1107	Homo sapiens (Human)	1792	FUNCTION: Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission. {ECO:0000250|UniProtKB:Q80TK0}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		AP-2 adaptor complex [GO:0030122]; axon [GO:0030424]; neuron projection terminus [GO:0044306]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021]		AP-2 adaptor complex [GO:0030122]; axon [GO:0030424]; neuron projection terminus [GO:0044306]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021]	SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000250|UniProtKB:Q80TK0}. Presynapse {ECO:0000250|UniProtKB:Q80TK0}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:D4A0X3}. Nucleus {ECO:0000269|PubMed:14654994}. Note=In primary cultures, mainly present at axonal and presynaptic terminal levels of mature neurons. In immature neurons, localizes to the cell body and growing processes, including axons (By similarity). Localized to nucleus in fetal cells (PubMed:14654994). {ECO:0000250|UniProtKB:Q80TK0, ECO:0000269|PubMed:14654994}.
Q5XKP0	reviewed	MIC13_HUMAN	MICOS complex subunit MIC13 (Protein P117)	MICOS13 C19orf70 MIC13 QIL1	Homo sapiens (Human)	118	FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex. {ECO:0000269|PubMed:25997101, ECO:0000269|PubMed:27623147}.		cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]	MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; SAM complex [GO:0001401]		MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; SAM complex [GO:0001401]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:25997101, ECO:0000269|PubMed:27184847}; Single-pass membrane protein {ECO:0000255}. Note=Enriched at crista junctions. {ECO:0000269|PubMed:25997101}.
Q5XKR4	reviewed	OTP_HUMAN	Homeobox protein orthopedia	OTP	Homo sapiens (Human)	325	FUNCTION: Probably involved in the differentiation of hypothalamic neuroendocrine cells.		dopaminergic neuron differentiation [GO:0071542]; forebrain neuron differentiation [GO:0021879]; hypothalamus cell differentiation [GO:0021979]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast proliferation [GO:0007405]; neuroendocrine cell differentiation [GO:0061101]; neurohypophysis development [GO:0021985]; neuron differentiation [GO:0030182]; positive regulation of neuroblast proliferation [GO:0002052]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; dopaminergic neuron differentiation [GO:0071542]; forebrain neuron differentiation [GO:0021879]; hypothalamus cell differentiation [GO:0021979]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast proliferation [GO:0007405]; neuroendocrine cell differentiation [GO:0061101]; neurohypophysis development [GO:0021985]; neuron differentiation [GO:0030182]; positive regulation of neuroblast proliferation [GO:0002052]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138, ECO:0000269|PubMed:10458915}.
Q5XLA6	reviewed	CAR17_HUMAN	Putative caspase recruitment domain-containing protein 17P (Caspase-1 inhibitor INCA) (Inhibitory caspase recruitment domain protein)	CARD17P CARD17 INCA	Homo sapiens (Human)	110	FUNCTION: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation. {ECO:0000269|PubMed:15383541}.		cellular response to lipopolysaccharide [GO:0071222]; negative regulation of interleukin-1 beta production [GO:0032691]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytoplasm [GO:0005737]; protein-containing complex [GO:0032991]	caspase binding [GO:0089720]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; protein-containing complex [GO:0032991]; caspase binding [GO:0089720]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; identical protein binding [GO:0042802]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of interleukin-1 beta production [GO:0032691]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q5XPI4	reviewed	RN123_HUMAN	E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123)	RNF123 KPC1 FP1477	Homo sapiens (Human)	1314	FUNCTION: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase (PubMed:15531880, PubMed:16227581, PubMed:25860612). Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle (PubMed:15531880, PubMed:16227581). Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit (PubMed:25860612, PubMed:33168738, PubMed:34873064). Functions also as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity (PubMed:27312109). Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS (PubMed:27312109). {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:16227581, ECO:0000269|PubMed:25860612, ECO:0000269|PubMed:27312109, ECO:0000269|PubMed:33168738, ECO:0000269|PubMed:34873064}.	MISCELLANEOUS: RNF123-mediated maturation of NFKB1 restricts tumor growth by promoting activation of the NF-kappa-B complex, leading to expression of tumor suppressor genes (PubMed:25860612, PubMed:33168738). Activation of NF-kappa-B promotes tumor suppression via CD274/PD-L1 and chemokines-mediated mechanisms (PubMed:33168738). {ECO:0000269|PubMed:25860612, ECO:0000269|PubMed:33168738}.	protein maturation [GO:0051604]; protein ubiquitination [GO:0016567]; proteolysis involved in protein catabolic process [GO:0051603]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; protein maturation [GO:0051604]; protein ubiquitination [GO:0016567]; proteolysis involved in protein catabolic process [GO:0051603]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:27312109}.
Q5XUX0	reviewed	FBX31_HUMAN	F-box only protein 31	FBXO31 FBX14 FBX31 PP2386	Homo sapiens (Human)	539	FUNCTION: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. {ECO:0000269|PubMed:16357137, ECO:0000269|PubMed:19412162}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; DNA damage response [GO:0006974]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytosol [GO:0005829]; neuronal cell body [GO:0043025]; SCF ubiquitin ligase complex [GO:0019005]	cyclin binding [GO:0030332]	cytosol [GO:0005829]; neuronal cell body [GO:0043025]; SCF ubiquitin ligase complex [GO:0019005]; cyclin binding [GO:0030332]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; DNA damage response [GO:0006974]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	
Q5XXA6	reviewed	ANO1_HUMAN	Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2)	ANO1 DOG1 ORAOV2 TAOS2 TMEM16A	Homo sapiens (Human)	986	FUNCTION: Calcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:21984732, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (PubMed:28963502). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825). However, was shown in another study not to be required for MUC5AC expression (PubMed:31732694). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (By similarity). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (By similarity). Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (By similarity). Acts as a heat sensor in nociceptive neurons (By similarity). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (By similarity). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q8BHY3, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21984732, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059, ECO:0000269|PubMed:28963502, ECO:0000269|PubMed:31732694, ECO:0000269|PubMed:32487539, ECO:0000269|PubMed:33026825}.; FUNCTION: [Isoform 4]: Calcium-activated chloride channel (CaCC). Contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Shows increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability. {ECO:0000269|PubMed:25220078}.; FUNCTION: [Isoform 5]: Calcium-activated chloride channel (CaCC). Shows increased sensitivity to intracellular Ca(2+). {ECO:0000269|PubMed:26359375}.	MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and are predicted to have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. {ECO:0000305}.	cellular response to heat [GO:0034605]; cellular response to peptide [GO:1901653]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; glial cell projection elongation [GO:0106091]; iodide transport [GO:0015705]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; mucus secretion [GO:0070254]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; protein localization to membrane [GO:0072657]	apical plasma membrane [GO:0016324]; cell projection [GO:0042995]; chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	calcium activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; intracellular calcium activated chloride channel activity [GO:0005229]; iodide transmembrane transporter activity [GO:0015111]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; voltage-gated chloride channel activity [GO:0005247]	apical plasma membrane [GO:0016324]; cell projection [GO:0042995]; chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; calcium activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; intracellular calcium activated chloride channel activity [GO:0005229]; iodide transmembrane transporter activity [GO:0015111]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; voltage-gated chloride channel activity [GO:0005247]; cellular response to heat [GO:0034605]; cellular response to peptide [GO:1901653]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; glial cell projection elongation [GO:0106091]; iodide transport [GO:0015705]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; mucus secretion [GO:0070254]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; protein localization to membrane [GO:0072657]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:15215166, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21984732, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059, ECO:0000269|PubMed:28559167, ECO:0000269|PubMed:31732694, ECO:0000269|PubMed:32487539}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8BHY3}. Presynapse {ECO:0000250|UniProtKB:Q8BHY3}. Note=In differentiating airway epithelial cells, predominantly intracellular at day 0 but is apically localized by day 30. Expressed in the presynapse of retinal neurons (By similarity). {ECO:0000250|UniProtKB:Q8BHY3}.
Q5ZPR3	reviewed	CD276_HUMAN	CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)	CD276 B7H3 PSEC0249 UNQ309/PRO352	Homo sapiens (Human)	534	FUNCTION: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}.	MISCELLANEOUS: B7-H3 locus underwent genomic duplication leading to tandemly repeated immunoglobulin-like V and C domains (VC domains). The dominantly expressed human B7-H3 isoform contains tandemly duplicated VC domains. In contrast, mouse B7-H3 transcript contains only one single VC domain form due to an exon structure corresponding to V domain-(pseudoexon C)-(pseudoexon V)-C domain. This duplication appearing in primates is suggested to be very recent supporting a model of multiple independent emergence of tandem VC repeats within human and monkey species.; MISCELLANEOUS: [Isoform 1]: Contains tandemly repeated immunoglobulin-like V and C domains.; MISCELLANEOUS: [Isoform 2]: Minor transcript. Contains one single set of immunoglobulin-like V and C domains. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Contains tandemly repeated immunoglobulin-like V and C domains. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Contains tandemly repeated immunoglobulin-like V and C domains. {ECO:0000305}.	positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]; regulation of cytokine production [GO:0001817]; regulation of immune response [GO:0050776]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; signaling receptor binding [GO:0005102]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]; regulation of cytokine production [GO:0001817]; regulation of immune response [GO:0050776]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q60I27	reviewed	AL2CL_HUMAN	ALS2 C-terminal-like protein	ALS2CL	Homo sapiens (Human)	953	FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. {ECO:0000269|PubMed:15388334, ECO:0000269|PubMed:16473597, ECO:0000269|PubMed:17239822}.		endosomal transport [GO:0016197]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; endosomal transport [GO:0016197]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15388334, ECO:0000269|PubMed:17239822}. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.
Q63HK5	reviewed	TSH3_HUMAN	Teashirt homolog 3 (Zinc finger protein 537)	TSHZ3 KIAA1474 TSH3 ZNF537	Homo sapiens (Human)	1081	FUNCTION: Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}.		long-term synaptic potentiation [GO:0060291]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; growth cone [GO:0030426]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	chromatin [GO:0000785]; growth cone [GO:0030426]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; long-term synaptic potentiation [GO:0060291]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:19343227}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. {ECO:0000250}.
Q63HN8	reviewed	RN213_HUMAN	E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213)	RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR	Homo sapiens (Human)	5207	FUNCTION: Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}.		angiogenesis [GO:0001525]; defense response to bacterium [GO:0042742]; immune system process [GO:0002376]; lipid droplet formation [GO:0140042]; lipid ubiquitination [GO:0120323]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of lipid metabolic process [GO:0019216]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511]; xenophagy [GO:0098792]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleolus [GO:0005730]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; angiogenesis [GO:0001525]; defense response to bacterium [GO:0042742]; immune system process [GO:0002376]; lipid droplet formation [GO:0140042]; lipid ubiquitination [GO:0120323]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of lipid metabolic process [GO:0019216]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511]; xenophagy [GO:0098792]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:34012115}. Lipid droplet {ECO:0000269|PubMed:30705059}.
Q63HQ0	reviewed	AP1AR_HUMAN	AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin)	AP1AR C4orf16 PRO0971	Homo sapiens (Human)	302	FUNCTION: Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}.		negative regulation of cell motility [GO:2000146]; negative regulation of receptor recycling [GO:0001920]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle targeting, trans-Golgi to endosome [GO:0048203]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; transport vesicle [GO:0030133]	AP-1 adaptor complex binding [GO:0035650]; kinesin binding [GO:0019894]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; transport vesicle [GO:0030133]; AP-1 adaptor complex binding [GO:0035650]; kinesin binding [GO:0019894]; negative regulation of cell motility [GO:2000146]; negative regulation of receptor recycling [GO:0001920]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle targeting, trans-Golgi to endosome [GO:0048203]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network. Late endosome. Early endosome. Note=Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery.
Q63HQ2	reviewed	EGFLA_HUMAN	Pikachurin (Agrin-like protein) (EGF-like, fibronectin type-III and laminin G-like domain-containing protein)	EGFLAM AGRINL AGRNL PIKA	Homo sapiens (Human)	1017	FUNCTION: Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Plays a key role in the synaptic organization of photoreceptors by mediating transsynaptic interaction between alpha-dystroglycan and GPR179 on the postsynaptic membrane. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness. {ECO:0000250|UniProtKB:Q4VBE4}.		extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]	basement membrane [GO:0005604]; cell projection [GO:0042995]; interstitial matrix [GO:0005614]; photoreceptor ribbon synapse [GO:0098684]; presynaptic active zone [GO:0048786]; synaptic cleft [GO:0043083]	calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]	basement membrane [GO:0005604]; cell projection [GO:0042995]; interstitial matrix [GO:0005614]; photoreceptor ribbon synapse [GO:0098684]; presynaptic active zone [GO:0048786]; synaptic cleft [GO:0043083]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q4VBE4}. Synaptic cleft {ECO:0000250|UniProtKB:Q4VBE4}. Presynaptic active zone {ECO:0000250|UniProtKB:Q4VBE4}. Note=Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells. Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals. {ECO:0000250|UniProtKB:Q4VBE4}.
Q63HR2	reviewed	TENS2_HUMAN	Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)	TNS2 KIAA1075 TENC1	Homo sapiens (Human)	1409	FUNCTION: Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}.		cellular homeostasis [GO:0019725]; collagen metabolic process [GO:0032963]; kidney development [GO:0001822]; multicellular organism growth [GO:0035264]; multicellular organismal-level homeostasis [GO:0048871]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; peptidyl-tyrosine dephosphorylation [GO:0035335]; response to muscle activity [GO:0014850]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; kinase binding [GO:0019900]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725]; cellular homeostasis [GO:0019725]; collagen metabolic process [GO:0032963]; kidney development [GO:0001822]; multicellular organism growth [GO:0035264]; multicellular organismal-level homeostasis [GO:0048871]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; peptidyl-tyrosine dephosphorylation [GO:0035335]; response to muscle activity [GO:0014850]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:11792844, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:22019427}. Cell membrane {ECO:0000269|PubMed:11792844, ECO:0000269|PubMed:30092354}; Peripheral membrane protein {ECO:0000269|PubMed:11792844}; Cytoplasmic side {ECO:0000269|PubMed:11792844}. Cytoplasm {ECO:0000269|PubMed:22019427, ECO:0000269|PubMed:25101860}. Note=Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies (PubMed:22019427, PubMed:25101860). Localizes to both focal adhesions and fibrillar adhesions but is found mainly in focal adhesions (PubMed:20069572). Enriched in dynamic focal adhesions at the leading edge of the cell and is found only rarely in fibrillar adhesions on the ventral surface of cells (PubMed:20069572). {ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:22019427, ECO:0000269|PubMed:25101860}.
Q63ZY3	reviewed	KANK2_HUMAN	KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein)	KANK2 ANKRD25 KIAA1518 MXRA3 SIP	Homo sapiens (Human)	851	FUNCTION: Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}.		apoptotic process [GO:0006915]; kidney epithelium development [GO:0072073]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D receptor signaling pathway [GO:0070563]; podocyte cell migration [GO:0090521]; regulation of Rho protein signal transduction [GO:0035023]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]		cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; apoptotic process [GO:0006915]; kidney epithelium development [GO:0072073]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D receptor signaling pathway [GO:0070563]; podocyte cell migration [GO:0090521]; regulation of Rho protein signal transduction [GO:0035023]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:25961457}. Mitochondrion {ECO:0000269|PubMed:22371500}.
Q63ZY6	reviewed	NSN5C_HUMAN	Putative methyltransferase NSUN5C (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 5C) (Williams-Beuren syndrome chromosomal region 20C protein)	NSUN5P2 NSUN5C WBSCR20B WBSCR20C	Homo sapiens (Human)	315	FUNCTION: May have S-adenosyl-L-methionine-dependent methyl-transferase activity. {ECO:0000305}.		rRNA base methylation [GO:0070475]	nucleolus [GO:0005730]	RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	nucleolus [GO:0005730]; RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; rRNA base methylation [GO:0070475]	
Q641Q2	reviewed	WAC2A_HUMAN	WASH complex subunit 2A	WASHC2A FAM21A FAM21B	Homo sapiens (Human)	1341	FUNCTION: Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.	MISCELLANEOUS: In human, WASHC2 has undergone evolutionary duplication, with 2 highly homologous family members WASHC2A and WASHC2C. {ECO:0000305}.	endosomal transport [GO:0016197]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; WASH complex [GO:0071203]	phosphatidylinositol phosphate binding [GO:1901981]; retromer complex binding [GO:1905394]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; WASH complex [GO:0071203]; phosphatidylinositol phosphate binding [GO:1901981]; retromer complex binding [GO:1905394]; endosomal transport [GO:0016197]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:28892079}. Cell membrane {ECO:0000250|UniProtKB:Q9Y4E1}.
Q643R3	reviewed	LPCT4_HUMAN	Lysophospholipid acyltransferase LPCAT4 (1-acylglycerol-3-phosphate O-acyltransferase 7) (1-AGP acyltransferase 7) (1-AGPAT 7) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (1-alkenylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.121) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acyltransferase-like 3) (Lysophosphatidylcholine acyltransferase 4) (Lysophosphatidylethanolamine acyltransferase 2) (EC 2.3.1.n7) (Plasmalogen synthase)	LPCAT4 AGPAT7 AYTL3 LPEAT2	Homo sapiens (Human)	524	FUNCTION: Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. {ECO:0000269|PubMed:18458083}.		phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 1-alkenylglycerophosphoethanolamine O-acyltransferase activity [GO:0047166]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; lysophosphatidic acid acyltransferase activity [GO:0042171]; lysophospholipid acyltransferase activity [GO:0071617]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 1-alkenylglycerophosphoethanolamine O-acyltransferase activity [GO:0047166]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; lysophosphatidic acid acyltransferase activity [GO:0042171]; lysophospholipid acyltransferase activity [GO:0071617]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16243729, ECO:0000269|PubMed:18458083}; Multi-pass membrane protein {ECO:0000269|PubMed:16243729, ECO:0000269|PubMed:18458083}.
Q64LD2	reviewed	WDR25_HUMAN	WD repeat-containing protein 25	WDR25 C14orf67	Homo sapiens (Human)	544							
Q658P3	reviewed	STEA3_HUMAN	Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde)	STEAP3 TSAP6	Homo sapiens (Human)	488	FUNCTION: Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:26205815). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (PubMed:15319436, PubMed:16651434). {ECO:0000250|UniProtKB:Q5RKL5, ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8CI59, ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:16651434, ECO:0000269|PubMed:26205815}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]; copper ion import [GO:0015677]; iron ion transmembrane transport [GO:0034755]; protein secretion [GO:0009306]; transferrin transport [GO:0033572]	cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]	cupric reductase activity [GO:0008823]; FAD binding [GO:0071949]; ferric-chelate reductase (NADPH) activity [GO:0052851]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor [GO:0016723]	cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; cupric reductase activity [GO:0008823]; FAD binding [GO:0071949]; ferric-chelate reductase (NADPH) activity [GO:0052851]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor [GO:0016723]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; copper ion import [GO:0015677]; iron ion transmembrane transport [GO:0034755]; protein secretion [GO:0009306]; transferrin transport [GO:0033572]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q8CI59}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus. {ECO:0000269|PubMed:15319436}.
Q659A1	reviewed	ICE2_HUMAN	Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2)	ICE2 BRCC1 NARG2 UNQ3101/PRO10100	Homo sapiens (Human)	982	FUNCTION: Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. {ECO:0000269|PubMed:23932780}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	positive regulation of transcription by RNA polymerase III [GO:0045945]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]	Cajal body [GO:0015030]; cytosol [GO:0005829]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]		Cajal body [GO:0015030]; cytosol [GO:0005829]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]; positive regulation of transcription by RNA polymerase III [GO:0045945]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23932780}. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
Q659C4	reviewed	LAR1B_HUMAN	La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2)	LARP1B LARP2	Homo sapiens (Human)	914			mRNA stabilization [GO:0048255]; positive regulation of translation [GO:0045727]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]	RNA binding [GO:0003723]; RNA cap binding [GO:0000339]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; mRNA stabilization [GO:0048255]; positive regulation of translation [GO:0045727]	
Q66GS9	reviewed	CP135_HUMAN	Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4)	CEP135 CEP4 KIAA0635	Homo sapiens (Human)	1140	FUNCTION: Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18851962, ECO:0000269|PubMed:26675238, ECO:0000269|PubMed:27185865}.		centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of non-motile cilium assembly [GO:1902857]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]		centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of non-motile cilium assembly [GO:1902857]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:32060285}. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.
Q66K64	reviewed	DCA15_HUMAN	DDB1- and CUL4-associated factor 15	DCAF15 C19orf72	Homo sapiens (Human)	600	FUNCTION: Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31452512}.; FUNCTION: Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 (PubMed:28437394, PubMed:28302793, PubMed:31693891, PubMed:31452512). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28437394, PubMed:28302793, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 (PubMed:31693891, PubMed:31626998, PubMed:31686031). {ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31452512, ECO:0000269|PubMed:31626998, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}.		immune system process [GO:0002376]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of natural killer cell activation [GO:0032814]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]	metal ion binding [GO:0046872]; small molecule binding [GO:0036094]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; metal ion binding [GO:0046872]; small molecule binding [GO:0036094]; immune system process [GO:0002376]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of natural killer cell activation [GO:0032814]	
Q66K74	reviewed	MAP1S_HUMAN	Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain]	MAP1S BPY2IP1 C19orf5 MAP8 VCY2IP1	Homo sapiens (Human)	1059	FUNCTION: Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}.	MISCELLANEOUS: Depletion of MAP1S by RNAi causes mitotic abnormalities that consist of failure to form a stable metaphase plate, premature sister chromatid separation, lagging chromosomes, and multipolar spindles.	apoptotic process [GO:0006915]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; brain development [GO:0007420]; dendrite development [GO:0016358]; metaphase chromosome alignment [GO:0051310]; microtubule anchoring at centrosome [GO:0034454]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; mitotic spindle organization [GO:0007052]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; regulation of microtubule depolymerization [GO:0031114]	cell junction [GO:0030054]; cell projection [GO:0042995]; centrosome [GO:0005813]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule organizing center [GO:0005815]; mitotic spindle microtubule [GO:1990498]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]; synapse [GO:0045202]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; beta-tubulin binding [GO:0048487]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631]	cell junction [GO:0030054]; cell projection [GO:0042995]; centrosome [GO:0005813]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule organizing center [GO:0005815]; mitotic spindle microtubule [GO:1990498]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]; synapse [GO:0045202]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; beta-tubulin binding [GO:0048487]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631]; apoptotic process [GO:0006915]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; brain development [GO:0007420]; dendrite development [GO:0016358]; metaphase chromosome alignment [GO:0051310]; microtubule anchoring at centrosome [GO:0034454]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; mitotic spindle organization [GO:0007052]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; regulation of microtubule depolymerization [GO:0031114]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Note=Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules. {ECO:0000250}.
Q66K79	reviewed	CBPZ_HUMAN	Carboxypeptidase Z (CPZ) (EC 3.4.17.-)	CPZ	Homo sapiens (Human)	652	FUNCTION: Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing. {ECO:0000269|PubMed:11766880, ECO:0000269|PubMed:12417617, ECO:0000269|PubMed:9099699}.		peptide metabolic process [GO:0006518]; protein processing [GO:0016485]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055]	extracellular space [GO:0005615]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	extracellular space [GO:0005615]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; peptide metabolic process [GO:0006518]; protein processing [GO:0016485]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10671522}.
Q66K80	reviewed	RUAS1_HUMAN	Putative uncharacterized protein RUSC1-AS1 (RUSC1 antisense RNA 1) (RUSC1 antisense gene protein 1)	RUSC1-AS1 C1orf104	Homo sapiens (Human)	236							
Q66K89	reviewed	E4F1_HUMAN	Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)	E4F1 E4F	Homo sapiens (Human)	784	FUNCTION: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.; FUNCTION: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.		cell cycle [GO:0007049]; cell division [GO:0051301]; DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of cell cycle process [GO:0010564]; regulation of mitotic cell cycle, embryonic [GO:0009794]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; spindle [GO:0005819]	cAMP response element binding [GO:0035497]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transferase activity [GO:0016740]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; cAMP response element binding [GO:0035497]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transferase activity [GO:0016740]; cell cycle [GO:0007049]; cell division [GO:0051301]; DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of cell cycle process [GO:0010564]; regulation of mitotic cell cycle, embryonic [GO:0009794]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm. Note=A small fraction is detected in the cytoplasm. Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis. {ECO:0000250}.
Q66PJ3	reviewed	AR6P4_HUMAN	ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL-6-interacting protein 4) (Aip-4) (HSP-975) (HSVI-binding protein) (SR-15) (SRp25) (SR-25) (Splicing factor SRrp37)	ARL6IP4	Homo sapiens (Human)	237	FUNCTION: Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA. {ECO:0000269|PubMed:19582790}.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]	RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:19582790}. Nucleus speckle {ECO:0000269|PubMed:19582790}.
Q674R7	reviewed	ATG9B_HUMAN	Autophagy-related protein 9B (APG9-like 2) (Nitric oxide synthase 3-overlapping antisense gene protein) (Protein sONE)	ATG9B APG9L2 NOS3AS	Homo sapiens (Human)	924	FUNCTION: Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000250|UniProtKB:Q7Z3C6}.	MISCELLANEOUS: ATG9B gene is located on the opposite DNA strand of the NOS3 gene at chromosome 7q36. The genes are oriented in a tail-to-tail configuration and the mRNAs encoding ATG9B and NOS3 are complementary for 662 nucleotides. ATG9B transcription may a role in NOS3 transcription regulation. {ECO:0000269|PubMed:15234981}.	autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; bone morphogenesis [GO:0060349]; late nucleophagy [GO:0044805]; programmed necrotic cell death [GO:0097300]; protein localization to phagophore assembly site [GO:0034497]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]	phospholipid scramblase activity [GO:0017128]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; phospholipid scramblase activity [GO:0017128]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; bone morphogenesis [GO:0060349]; late nucleophagy [GO:0044805]; programmed necrotic cell death [GO:0097300]; protein localization to phagophore assembly site [GO:0034497]	SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000269|PubMed:18936157}; Multi-pass membrane protein {ECO:0000269|PubMed:18936157}. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool (PubMed:18936157). The starvation-induced redistribution depends on ULK1 and ATG13 (PubMed:18936157). {ECO:0000269|PubMed:18936157}.
Q674X7	reviewed	KAZRN_HUMAN	Kazrin	KAZN C1orf196 KAZ KIAA1026 HRIHFB2003	Homo sapiens (Human)	775	FUNCTION: Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}.		keratinization [GO:0031424]	cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]		cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; keratinization [GO:0031424]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.
Q676U5	reviewed	A16L1_HUMAN	Autophagy-related protein 16-1 (APG16-like 1)	ATG16L1 APG16L UNQ9393/PRO34307	Homo sapiens (Human)	607	FUNCTION: Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:29317426, PubMed:30778222, PubMed:33909989, PubMed:24553140, PubMed:24954904, PubMed:27273576). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	autophagosome assembly [GO:0000045]; C-terminal protein lipidation [GO:0006501]; corpus callosum development [GO:0022038]; defense response to virus [GO:0051607]; hippocampus development [GO:0021766]; lysosomal microautophagy [GO:0016237]; macroautophagy [GO:0016236]; negative stranded viral RNA replication [GO:0039689]; positive regulation of autophagy [GO:0010508]; protein localization to phagophore assembly site [GO:0034497]; protein transport [GO:0015031]; xenophagy [GO:0098792]	Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; phagophore assembly site membrane [GO:0034045]; sperm midpiece [GO:0097225]; vacuole-isolation membrane contact site [GO:0120095]	GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; protein-membrane adaptor activity [GO:0043495]; ubiquitin-like protein transferase activity [GO:0019787]	Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; phagophore assembly site membrane [GO:0034045]; sperm midpiece [GO:0097225]; vacuole-isolation membrane contact site [GO:0120095]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; protein-membrane adaptor activity [GO:0043495]; ubiquitin-like protein transferase activity [GO:0019787]; autophagosome assembly [GO:0000045]; C-terminal protein lipidation [GO:0006501]; corpus callosum development [GO:0022038]; defense response to virus [GO:0051607]; hippocampus development [GO:0021766]; lysosomal microautophagy [GO:0016237]; macroautophagy [GO:0016236]; negative stranded viral RNA replication [GO:0039689]; positive regulation of autophagy [GO:0010508]; protein localization to phagophore assembly site [GO:0034497]; protein transport [GO:0015031]; xenophagy [GO:0098792]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23392225}. Preautophagosomal structure membrane {ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:23392225}; Peripheral membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:29317426}; Peripheral membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:29317426}; Peripheral membrane protein {ECO:0000305}. Note=Recruited to omegasomes membranes by WIPI2 (By similarity). Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (By similarity). Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5 (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). Upon activation of non-canonical autophagy, recruited to single-membrane endolysosomal compartments (PubMed:29317426). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:29317426}.
Q684P5	reviewed	RPGP2_HUMAN	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4)	RAP1GAP2 GARNL4 KIAA1039 RAP1GA2	Homo sapiens (Human)	730	FUNCTION: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}.		adaptive immune response [GO:0002250]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; adaptive immune response [GO:0002250]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15632203}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15632203}.
Q685J3	reviewed	MUC17_HUMAN	Mucin-17 (MUC-17) (Small intestinal mucin-3) (MUC-3)	MUC17 MUC3	Homo sapiens (Human)	4493	FUNCTION: Probably plays a role in maintaining homeostasis on mucosal surfaces. {ECO:0000269|PubMed:17990980}.		cellular homeostasis [GO:0019725]	apical plasma membrane [GO:0016324]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	extracellular matrix constituent, lubricant activity [GO:0030197]; PDZ domain binding [GO:0030165]	apical plasma membrane [GO:0016324]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; extracellular matrix constituent, lubricant activity [GO:0030197]; PDZ domain binding [GO:0030165]; cellular homeostasis [GO:0019725]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}. Cell membrane.
Q687X5	reviewed	STEA4_HUMAN	Metalloreductase STEAP4 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9)	STEAP4 STAMP2 TNFAIP9	Homo sapiens (Human)	459	FUNCTION: Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193). {ECO:0000250|UniProtKB:Q923B6, ECO:0000269|PubMed:18381574, ECO:0000269|PubMed:18430367, ECO:0000269|PubMed:19660107, ECO:0000269|PubMed:19787193, ECO:0000269|PubMed:30337524}.		copper ion import [GO:0015677]; fat cell differentiation [GO:0045444]; iron import into cell [GO:0033212]; iron ion transmembrane transport [GO:0034755]; protein homotrimerization [GO:0070207]	early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	cupric reductase activity [GO:0008823]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; ferric-chelate reductase (NADPH) activity [GO:0052851]; heme binding [GO:0020037]; metal ion binding [GO:0046872]	early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cupric reductase activity [GO:0008823]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; ferric-chelate reductase (NADPH) activity [GO:0052851]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; copper ion import [GO:0015677]; fat cell differentiation [GO:0045444]; iron import into cell [GO:0033212]; iron ion transmembrane transport [GO:0034755]; protein homotrimerization [GO:0070207]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15897894, ECO:0000269|PubMed:18430367}; Multi-pass membrane protein {ECO:0000269|PubMed:30337524}. Golgi apparatus membrane {ECO:0000269|PubMed:15897894}; Multi-pass membrane protein {ECO:0000269|PubMed:30337524}. Early endosome membrane {ECO:0000269|PubMed:15897894}; Multi-pass membrane protein {ECO:0000269|PubMed:30337524}.
Q68CJ6	reviewed	SLIP_HUMAN	Nuclear GTPase SLIP-GC (EC 3.6.1.-) (Speckled-like pattern in the germinal center)	NUGGC C8orf80 HMFN0672	Homo sapiens (Human)	796	FUNCTION: Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity). {ECO:0000250|UniProtKB:D3YWJ0, ECO:0000269|PubMed:19734146}.		cellular response to lipopolysaccharide [GO:0071222]; negative regulation of apoptotic process [GO:0043066]; regulation of nuclear cell cycle DNA replication [GO:0033262]	nuclear speck [GO:0016607]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	nuclear speck [GO:0016607]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of apoptotic process [GO:0043066]; regulation of nuclear cell cycle DNA replication [GO:0033262]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:19734146}.
Q68CJ9	reviewed	CR3L3_HUMAN	Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]	CREB3L3 CREBH HYST1481	Homo sapiens (Human)	461	FUNCTION: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (PubMed:21666694). {ECO:0000250, ECO:0000250|UniProtKB:Q91XE9, ECO:0000269|PubMed:11353085, ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:16469704, ECO:0000269|PubMed:21666694}.		positive regulation of acute inflammatory response [GO:0002675]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; regulation of transcription by RNA polymerase II [GO:0006357]; response to unfolded protein [GO:0006986]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; regulation of transcription by RNA polymerase II [GO:0006357]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11353085}; Single-pass type II membrane protein {ECO:0000269|PubMed:11353085}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus {ECO:0000269|PubMed:30389664}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Q68CK6	reviewed	ACS2B_HUMAN	Acyl-coenzyme A synthetase ACSM2B, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 2B) (Benzoate--CoA ligase) (EC 6.2.1.25) (Butyrate--CoA ligase 2B) (Butyryl-coenzyme A synthetase 2B) (Middle-chain acyl-CoA synthetase 2B) (Xenobiotic/medium-chain fatty acid-CoA ligase HXM-A)	ACSM2B ACSM2 HYST1046	Homo sapiens (Human)	577	FUNCTION: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065, PubMed:12616642). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10434065, PubMed:12616642). {ECO:0000269|PubMed:10434065, ECO:0000269|PubMed:12616642}.		acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; xenobiotic metabolic process [GO:0006805]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; benzoate-CoA ligase activity [GO:0018858]; butyrate-CoA ligase activity [GO:0047760]; CoA-ligase activity [GO:0016405]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; metal ion binding [GO:0046872]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; benzoate-CoA ligase activity [GO:0018858]; butyrate-CoA ligase activity [GO:0047760]; CoA-ligase activity [GO:0016405]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; metal ion binding [GO:0046872]; acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10434065, ECO:0000269|PubMed:12616642, ECO:0000269|PubMed:19634011}.
Q68CP4	reviewed	HGNAT_HUMAN	Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76)	HGSNAT TMEM76	Homo sapiens (Human)	663	FUNCTION: Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:19823584, ECO:0000269|PubMed:20650889}.	MISCELLANEOUS: A signal sequence is predicted but has been shown not to be cleaved in the reticulum endoplasmic.; MISCELLANEOUS: [Isoform 1]: Intralysosomal proteolytic cleavage is faster and enzymatic activity higher than isoform 2.	heparan sulfate proteoglycan catabolic process [GO:0030200]; lysosomal transport [GO:0007041]; protein complex oligomerization [GO:0051259]	lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	acyltransferase activity [GO:0016746]; heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019]	lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; acyltransferase activity [GO:0016746]; heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019]; heparan sulfate proteoglycan catabolic process [GO:0030200]; lysosomal transport [GO:0007041]; protein complex oligomerization [GO:0051259]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:17897319}. Note=Colocalizes with the lysosomal marker LAMP2. The signal peptide is not cleaved upon translocation into the endoplasmic reticulum; the precursor is probably targeted to the lysosomes via the adapter protein complex-mediated pathway that involves tyrosine- and/or dileucine-based conserved amino acid motifs in the last C-terminus 16-amino acid domain.
Q68CP9	reviewed	ARID2_HUMAN	AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200)	ARID2 BAF200 KIAA1557	Homo sapiens (Human)	1835	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.		cardiac muscle cell proliferation [GO:0060038]; chromatin remodeling [GO:0006338]; coronary artery morphogenesis [GO:0060982]; embryonic organ development [GO:0048568]; heart morphogenesis [GO:0003007]; homeostatic process [GO:0042592]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; cardiac muscle cell proliferation [GO:0060038]; chromatin remodeling [GO:0006338]; coronary artery morphogenesis [GO:0060982]; embryonic organ development [GO:0048568]; heart morphogenesis [GO:0003007]; homeostatic process [GO:0042592]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q68CQ1	reviewed	MROH7_HUMAN	Maestro heat-like repeat-containing protein family member 7 (HEAT repeat-containing protein 8)	MROH7 C1orf175 HEATR8	Homo sapiens (Human)	1323		MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]		cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q68CQ4	reviewed	UTP25_HUMAN	U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor homolog) (UTP25 small subunit processor component)	UTP25 C1orf107 DEF DIEXF	Homo sapiens (Human)	756	FUNCTION: Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:25007945, PubMed:27657329, PubMed:23357851). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). {ECO:0000250|UniProtKB:Q6PEH4, ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:25007945, ECO:0000269|PubMed:27657329}.		embryonic organ development [GO:0048568]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of embryonic development [GO:0040019]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to nucleolus [GO:1902570]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]; U3 snoRNA binding [GO:0034511]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; U3 snoRNA binding [GO:0034511]; embryonic organ development [GO:0048568]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of embryonic development [GO:0040019]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to nucleolus [GO:1902570]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:27657329}.
Q68CZ1	reviewed	FTM_HUMAN	Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein)	RPGRIP1L FTM KIAA1005 NPHP8	Homo sapiens (Human)	1315	FUNCTION: Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (PubMed:19464661). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (PubMed:19464661). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (By similarity). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (By similarity). {ECO:0000250|UniProtKB:Q8CG73, ECO:0000269|PubMed:19464661}.		cerebellum development [GO:0021549]; cochlea development [GO:0090102]; corpus callosum development [GO:0022038]; determination of left/right symmetry [GO:0007368]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; establishment of planar polarity [GO:0001736]; establishment or maintenance of cell polarity [GO:0007163]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lateral ventricle development [GO:0021670]; liver development [GO:0001889]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; nose development [GO:0043584]; olfactory bulb development [GO:0021772]; pericardium development [GO:0060039]; regulation of smoothened signaling pathway [GO:0008589]; retinal rod cell development [GO:0046548]	axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886]	thromboxane A2 receptor binding [GO:0031870]	axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886]; thromboxane A2 receptor binding [GO:0031870]; cerebellum development [GO:0021549]; cochlea development [GO:0090102]; corpus callosum development [GO:0022038]; determination of left/right symmetry [GO:0007368]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; establishment of planar polarity [GO:0001736]; establishment or maintenance of cell polarity [GO:0007163]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lateral ventricle development [GO:0021670]; liver development [GO:0001889]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; nose development [GO:0043584]; olfactory bulb development [GO:0021772]; pericardium development [GO:0060039]; regulation of smoothened signaling pathway [GO:0008589]; retinal rod cell development [GO:0046548]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8CG73, ECO:0000269|PubMed:21685204}. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8CG73}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q8CG73}. Note=In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions. Localizes to the ciliary transition zone. {ECO:0000250|UniProtKB:Q8CG73}.
Q68CZ2	reviewed	TENS3_HUMAN	Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6)	TNS3 TEM6 TENS1 TPP	Homo sapiens (Human)	1445	FUNCTION: May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.		dephosphorylation [GO:0016311]	cell projection [GO:0042995]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; podosome [GO:0002102]	phosphoprotein phosphatase activity [GO:0004721]	cell projection [GO:0042995]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; podosome [GO:0002102]; phosphoprotein phosphatase activity [GO:0004721]; dephosphorylation [GO:0016311]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:15140944, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:35687021}. Cell projection, podosome {ECO:0000250|UniProtKB:Q5SSZ5}. Note=Localizes to both focal and fibrillar adhesions but is mostly found in fibrillar adhesions. {ECO:0000269|PubMed:20069572}.
Q68CZ6	reviewed	HAUS3_HUMAN	HAUS augmin-like complex subunit 3	HAUS3 C4orf15	Homo sapiens (Human)	603	FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.		cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]		centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:19427217}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}.
Q68D06	reviewed	SLN13_HUMAN	Schlafen family member 13 (EC 3.1.-.-) (Schlafen-13) (hSLFN13)	SLFN13	Homo sapiens (Human)	897	FUNCTION: Endoribonuclease that cleaves tRNAs and rRNAs (PubMed:29563550). Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem (PubMed:29563550). Does not act on tRNA(Sec) (PubMed:29563550). Able to restrict HIV-1 virus replication; ability to inhibit HIV-1 replication is dependent on endoribonuclease activity (PubMed:29563550). {ECO:0000269|PubMed:29563550}.		defense response to virus [GO:0051607]; rRNA catabolic process [GO:0016075]; tRNA catabolic process [GO:0016078]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; RNA endonuclease activity [GO:0004521]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; RNA endonuclease activity [GO:0004521]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; defense response to virus [GO:0051607]; rRNA catabolic process [GO:0016075]; tRNA catabolic process [GO:0016078]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29563550}.
Q68D10	reviewed	SPT2_HUMAN	Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1)	SPTY2D1	Homo sapiens (Human)	685	FUNCTION: Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026). {ECO:0000250|UniProtKB:E1BUG7, ECO:0000269|PubMed:23378026}.	MISCELLANEOUS: The histone binding domain can functionally complement the yeast ortholog in regulating histone exchange and suppression of spurious transcription. {ECO:0000269|PubMed:26109053}.	heterochromatin formation [GO:0031507]; nucleosome assembly [GO:0006334]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase I [GO:0006360]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; RNA polymerase I core binding [GO:0001042]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; RNA polymerase I core binding [GO:0001042]; heterochromatin formation [GO:0031507]; nucleosome assembly [GO:0006334]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase I [GO:0006360]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:E1BUG7}.
Q68D85	reviewed	NR3L1_HUMAN	Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6)	NCR3LG1 B7H6	Homo sapiens (Human)	454	FUNCTION: Triggers NCR3-dependent natural killer cell activation. {ECO:0000269|PubMed:19528259}.		antibacterial humoral response [GO:0019731]; complement activation, classical pathway [GO:0006958]	immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]	immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]; antibacterial humoral response [GO:0019731]; complement activation, classical pathway [GO:0006958]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19528259}; Single-pass type I membrane protein {ECO:0000269|PubMed:19528259}.
Q68D86	reviewed	C102B_HUMAN	Coiled-coil domain-containing protein 102B	CCDC102B C18orf14	Homo sapiens (Human)	513	FUNCTION: During interphase, forms fibers at the proximal ends of centrioles to maintain centrosome cohesion (PubMed:30404835). During mitosis, dissociates from the centrosome following phosphorylation to allow centrosome separation (PubMed:30404835). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:30404835}.		centriole-centriole cohesion [GO:0010457]	centriole [GO:0005814]; cytoplasm [GO:0005737]	protein serine/threonine kinase binding [GO:0120283]	centriole [GO:0005814]; cytoplasm [GO:0005737]; protein serine/threonine kinase binding [GO:0120283]; centriole-centriole cohesion [GO:0010457]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30404835}. Note=Concentrated at the proximal ends of centrioles where it forms fibers (PubMed:30404835). Centrosomal localization becomes weak when cells enter prophase and is significantly decreased in metaphase (PubMed:30404835). {ECO:0000269|PubMed:30404835}.
Q68D91	reviewed	MBLC2_HUMAN	Acyl-coenzyme A thioesterase MBLAC2 (Acyl-CoA thioesterase MBLAC2) (EC 3.1.2.2) (Beta-lactamase MBLAC2) (EC 3.5.2.6) (Metallo-beta-lactamase domain-containing protein 2) (Palmitoyl-coenzyme A thioesterase MBLAC2)	MBLAC2	Homo sapiens (Human)	279	FUNCTION: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:33219126). Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:33219126). Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18 (PubMed:33219126). Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). {ECO:0000269|PubMed:31434986, ECO:0000269|PubMed:33219126}.		fatty acid metabolic process [GO:0006631]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	beta-lactamase activity [GO:0008800]; metal ion binding [GO:0046872]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; beta-lactamase activity [GO:0008800]; metal ion binding [GO:0046872]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; fatty acid metabolic process [GO:0006631]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:33219126}; Lipid-anchor {ECO:0000269|PubMed:33219126}. Cell membrane {ECO:0000269|PubMed:33219126}; Lipid-anchor {ECO:0000269|PubMed:33219126}.
Q68DA7	reviewed	FMN1_HUMAN	Formin-1 (Limb deformity protein homolog)	FMN1 FMN LD	Homo sapiens (Human)	1419	FUNCTION: Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}.		actin nucleation [GO:0045010]; forelimb morphogenesis [GO:0035136]; gene expression [GO:0010467]; hindlimb morphogenesis [GO:0035137]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of actin nucleation [GO:0051127]; positive regulation of focal adhesion assembly [GO:0051894]; skeletal system morphogenesis [GO:0048705]; ureteric bud invasion [GO:0072092]	actin filament [GO:0005884]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; microtubule binding [GO:0008017]; SH3 domain binding [GO:0017124]	actin filament [GO:0005884]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; microtubule binding [GO:0008017]; SH3 domain binding [GO:0017124]; actin nucleation [GO:0045010]; forelimb morphogenesis [GO:0035136]; gene expression [GO:0010467]; hindlimb morphogenesis [GO:0035137]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of actin nucleation [GO:0051127]; positive regulation of focal adhesion assembly [GO:0051894]; skeletal system morphogenesis [GO:0048705]; ureteric bud invasion [GO:0072092]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Localization to the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions and to microtubules (By similarity). {ECO:0000250}.
Q68DC2	reviewed	ANKS6_HUMAN	Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6)	ANKS6 ANKRD14 PKDR1 SAMD6	Homo sapiens (Human)	871	FUNCTION: Required for renal function. {ECO:0000269|PubMed:23793029}.		determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]	ciliary inversin compartment [GO:0097543]; cytoplasm [GO:0005737]		ciliary inversin compartment [GO:0097543]; cytoplasm [GO:0005737]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q6GQX6}. Cytoplasm {ECO:0000250|UniProtKB:P0C0T2}. Note=Localizes to the proximal region of the primary cilium in the presence of INVS. {ECO:0000250|UniProtKB:Q6GQX6}.
Q68DD2	reviewed	PA24F_HUMAN	Cytosolic phospholipase A2 zeta (cPLA2-zeta) (EC 3.1.1.4) (Phospholipase A2 group IVF)	PLA2G4F	Homo sapiens (Human)	849	FUNCTION: Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:29158256). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:29158256). In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (PubMed:29158256). {ECO:0000269|PubMed:29158256}.		arachidonic acid secretion [GO:0050482]; cellular response to antibiotic [GO:0071236]; cellular response to organic cyclic compound [GO:0071407]; glycerophospholipid catabolic process [GO:0046475]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; prostaglandin biosynthetic process [GO:0001516]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; ruffle membrane [GO:0032587]; vesicle [GO:0031982]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; lysophospholipase activity [GO:0004622]; phospholipase A1 activity [GO:0008970]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; ruffle membrane [GO:0032587]; vesicle [GO:0031982]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; lysophospholipase activity [GO:0004622]; phospholipase A1 activity [GO:0008970]; arachidonic acid secretion [GO:0050482]; cellular response to antibiotic [GO:0071236]; cellular response to organic cyclic compound [GO:0071407]; glycerophospholipid catabolic process [GO:0046475]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; prostaglandin biosynthetic process [GO:0001516]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q50L41}. Cell membrane {ECO:0000250|UniProtKB:Q50L41}; Peripheral membrane protein {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:29158256}.
Q68DE3	reviewed	USF3_HUMAN	Basic helix-loop-helix domain-containing protein USF3 (Upstream transcription factor 3)	USF3 KIAA2018	Homo sapiens (Human)	2245	FUNCTION: Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties. {ECO:0000269|PubMed:28011713}.		negative regulation of epithelial to mesenchymal transition [GO:0010719]; positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q68DK2	reviewed	ZFY26_HUMAN	Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin)	ZFYVE26 KIAA0321	Homo sapiens (Human)	2539	FUNCTION: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}.		autophagosome organization [GO:1905037]; double-strand break repair via homologous recombination [GO:0000724]; lysosome organization [GO:0007040]; mitotic cytokinesis [GO:0000281]; regulation of cytokinesis [GO:0032465]	centrosome [GO:0005813]; early endosome [GO:0005769]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; midbody [GO:0030496]	metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein kinase binding [GO:0019901]	centrosome [GO:0005813]; early endosome [GO:0005769]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; midbody [GO:0030496]; metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein kinase binding [GO:0019901]; autophagosome organization [GO:1905037]; double-strand break repair via homologous recombination [GO:0000724]; lysosome organization [GO:0007040]; mitotic cytokinesis [GO:0000281]; regulation of cytokinesis [GO:0032465]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20208530}. Midbody {ECO:0000269|PubMed:20208530}. Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.
Q68DK7	reviewed	MSL1_HUMAN	Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1)	MSL1 MSL1L1	Homo sapiens (Human)	614	FUNCTION: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). {ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026}.		chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	MSL complex [GO:0072487]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	MSL complex [GO:0072487]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15561718}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q6PDM1}. Nucleus speckle {ECO:0000250|UniProtKB:Q6PDM1}.
Q68DQ2	reviewed	CRBG3_HUMAN	Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3)	CRYBG3	Homo sapiens (Human)	2970	FUNCTION: [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}.		lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]	protein-containing complex [GO:0032991]	carbohydrate binding [GO:0030246]; protein kinase A binding [GO:0051018]; structural constituent of eye lens [GO:0005212]	protein-containing complex [GO:0032991]; carbohydrate binding [GO:0030246]; protein kinase A binding [GO:0051018]; structural constituent of eye lens [GO:0005212]; lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]	
Q68DV7	reviewed	RNF43_HUMAN	E3 ubiquitin-protein ligase RNF43 (EC 2.3.2.27) (RING finger protein 43) (RING-type E3 ubiquitin transferase RNF43)	RNF43	Homo sapiens (Human)	783	FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity). {ECO:0000250|UniProtKB:P0DPR2, ECO:0000269|PubMed:18313049, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22895187}.	MISCELLANEOUS: Acts as a cytotoxic T-lymphocyte tumor antigen, suggesting that it may be used as a target for cancer immunotherapy. {ECO:0000305|PubMed:15623641}.	negative regulation of Wnt signaling pathway [GO:0030178]; protein ubiquitination [GO:0016567]; stem cell proliferation [GO:0072089]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt receptor catabolic process [GO:0038018]; Wnt signaling pathway [GO:0016055]	endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]	frizzled binding [GO:0005109]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; frizzled binding [GO:0005109]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; negative regulation of Wnt signaling pathway [GO:0030178]; protein ubiquitination [GO:0016567]; stem cell proliferation [GO:0072089]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt receptor catabolic process [GO:0038018]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269|PubMed:15492824}.
Q68DX3	reviewed	FRPD2_HUMAN	FERM and PDZ domain-containing protein 2 (PDZ domain-containing protein 4) (PDZ domain-containing protein 5C)	FRMPD2 PDZD5C PDZK4 PDZK5C	Homo sapiens (Human)	1309	FUNCTION: May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). {ECO:0000269|PubMed:19706687}.		bicellular tight junction assembly [GO:0070830]; microtubule organizing center organization [GO:0031023]; regulation of microtubule cytoskeleton organization [GO:0070507]	apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]	1-phosphatidylinositol binding [GO:0005545]	apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; 1-phosphatidylinositol binding [GO:0005545]; bicellular tight junction assembly [GO:0070830]; microtubule organizing center organization [GO:0031023]; regulation of microtubule cytoskeleton organization [GO:0070507]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:19706687}. Cell junction, tight junction {ECO:0000269|PubMed:19706687}. Note=Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes with TJP1 at tight junctions. Its recruitment to cell-cell contacts requires CDH1.
Q68E01	reviewed	INT3_HUMAN	Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A)	INTS3 C1orf193 C1orf60	Homo sapiens (Human)	1043	FUNCTION: Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.; FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic G2/M transition checkpoint [GO:0044818]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; response to ionizing radiation [GO:0010212]; snRNA processing [GO:0016180]	cytoplasm [GO:0005737]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876]		cytoplasm [GO:0005737]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic G2/M transition checkpoint [GO:0044818]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; response to ionizing radiation [GO:0010212]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501, ECO:0000269|PubMed:23904267}. Cytoplasm {ECO:0000269|PubMed:23904267}. Note=Localizes to nuclear foci following DNA damage.
Q68EA5	reviewed	ZNF57_HUMAN	Zinc finger protein 57 (Zinc finger protein 424)	ZNF57 ZNF424	Homo sapiens (Human)	555	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q68EM7	reviewed	RHG17_HUMAN	Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)	ARHGAP17 RICH1 MSTP066 MSTP110	Homo sapiens (Human)	881	FUNCTION: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.		actin filament organization [GO:0007015]; calcium-ion regulated exocytosis [GO:0017156]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of Rac protein signal transduction [GO:0035020]; signal transduction [GO:0007165]	bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]	bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]; actin filament organization [GO:0007015]; calcium-ion regulated exocytosis [GO:0017156]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of Rac protein signal transduction [GO:0035020]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact.
Q68EN5	reviewed	MACA1_HUMAN	Microtubule-associated tyrosine carboxypeptidase 1 (EC 3.4.17.17) (Microtubule-associated tyrosine carboxypeptidase)	MATCAP1 KIAA0895L MATCAP	Homo sapiens (Human)	471	FUNCTION: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:35482892). Also able to remove the C-terminal phenylalanine residue of alpha-tubulin TUBA8 (PubMed:35482892). Recognizes adjacent tubulin dimers along the same protofilament (PubMed:35482892). {ECO:0000269|PubMed:35482892}.		brain development [GO:0007420]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; microtubule [GO:0005874]	metallocarboxypeptidase activity [GO:0004181]; tubulin-tyrosine carboxypeptidase [GO:0106423]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; metallocarboxypeptidase activity [GO:0004181]; tubulin-tyrosine carboxypeptidase [GO:0106423]; brain development [GO:0007420]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:35482892}. Note=Associates with microtubules. {ECO:0000269|PubMed:35482892}.
Q68G74	reviewed	LHX8_HUMAN	LIM/homeobox protein Lhx8 (LIM homeobox protein 8)	LHX8	Homo sapiens (Human)	356	FUNCTION: Transcription factor involved in differentiation of certain neurons and mesenchymal cells. {ECO:0000250}.		female gonad development [GO:0008585]; forebrain neuron development [GO:0021884]; learning or memory [GO:0007611]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; female germ cell nucleus [GO:0001674]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; female germ cell nucleus [GO:0001674]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; female gonad development [GO:0008585]; forebrain neuron development [GO:0021884]; learning or memory [GO:0007611]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q68G75	reviewed	LEMD1_HUMAN	LEM domain-containing protein 1 (Cancer/testis antigen 50) (CT50) (LEM domain protein 1) (LEMP-1)	LEMD1	Homo sapiens (Human)	181		MISCELLANEOUS: [Isoform 6]: Found at the nuclear membrane. {ECO:0000305}.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q68J44	reviewed	DUS29_HUMAN	Dual specificity phosphatase 29 (Dual specificity phosphatase 27) (Dual specificity phosphatase DUPD1) (EC 3.1.3.16, EC 3.1.3.48)	DUSP29 DUPD1 DUSP27	Homo sapiens (Human)	220	FUNCTION: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (PubMed:17498703). Involved in the modulation of intracellular signaling cascades. In skeletal muscle regulates systemic glucose homeostasis by activating, AMPK, an energy sensor protein kinase (By similarity). Affects MAP kinase signaling though modulation of the MAPK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (By similarity). {ECO:0000250|UniProtKB:Q8BK84, ECO:0000269|PubMed:17498703}.		glucose homeostasis [GO:0042593]; muscle cell differentiation [GO:0042692]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	MAP kinase phosphatase activity [GO:0033549]; myosin phosphatase activity [GO:0017018]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; MAP kinase phosphatase activity [GO:0033549]; myosin phosphatase activity [GO:0017018]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; glucose homeostasis [GO:0042593]; muscle cell differentiation [GO:0042692]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17498703}. Nucleus {ECO:0000250|UniProtKB:Q8BK84}.
Q69383	reviewed	REC6_HUMAN	Endogenous retrovirus group K member 6 Rec protein (Central open reading frame) (c-orf) (cORF) (Endogenous retrovirus K protein 6) (HERV-K(C7) Rec protein) (HERV-K(HML-2.HOM) Rec protein) (HERV-K108 Rec protein) (HERV-K_7p22.1 provirus Rec protein) (K-Rev) (Rev-like protein) (Rev/Rex homolog)	ERVK-6 ERVK6	Homo sapiens (Human)	105	FUNCTION: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts. {ECO:0000269|PubMed:10516058, ECO:0000269|PubMed:10557333, ECO:0000269|PubMed:10980608, ECO:0000269|PubMed:11000203, ECO:0000269|PubMed:11105755, ECO:0000269|PubMed:11581404}.	MISCELLANEOUS: Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex.; MISCELLANEOUS: Two proviruses inserted as tandem repeats in most of individuals tested. Both proviral genomes encode identical Rec proteins.; MISCELLANEOUS: This Rec protein is encoded by a human specific provirus.; MISCELLANEOUS: Has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HML-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3' part of the proviral genome.	mRNA export from nucleus [GO:0006406]; positive regulation of gene expression [GO:0010628]; protein homooligomerization [GO:0051260]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; protein-containing complex [GO:0032991]	protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; protein-containing complex [GO:0032991]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; mRNA export from nucleus [GO:0006406]; positive regulation of gene expression [GO:0010628]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus.
Q69384	reviewed	ENK6_HUMAN	Endogenous retrovirus group K member 6 Env polyprotein (EnvK2 protein) (Envelope polyprotein) (HERV-K(C7) envelope protein) (HERV-K(HML-2.HOM) envelope protein) (HERV-K108 envelope protein) (HERV-K_7p22.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERVK-6 ERVK6	Homo sapiens (Human)	699	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: Two human-specific proviruses are inserted as tandem repeats with a shared LTR in most individuals tested. The telomeric copy is referred here as 'provirus 41574'. The centromeric copy is referred here as 'provirus 41575'.; MISCELLANEOUS: ERVK-6 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.		plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.; SUBCELLULAR LOCATION: [Endogenous retrovirus group K member 6 Env polyprotein]: Virion {ECO:0000250}.
Q693B1	reviewed	KCD11_HUMAN	BTB/POZ domain-containing protein KCTD11 (KCASH1 protein) (Potassium channel tetramerization domain-containing protein 11) (RING-type E3 ubiquitin transferase subunit KCTD11)	KCTD11 C17orf36 REN	Homo sapiens (Human)	232	FUNCTION: Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. {ECO:0000269|PubMed:15249678, ECO:0000269|PubMed:20081843, ECO:0000269|PubMed:21237243}.	MISCELLANEOUS: Haploinsufficiency of KCTD11 may be a cause of development of medulloblastoma (MDB). MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. An allelic deletion involving genes from chromosome region 17p11.2-pter, sometimes restricted to 17p13.2-13.3, occurs in up to 50% of MDB.; MISCELLANEOUS: [Isoform 2]: Non-AUG start codon. {ECO:0000305}.	cell cycle [GO:0007049]; positive regulation of neuron differentiation [GO:0045666]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]		identical protein binding [GO:0042802]; transferase activity [GO:0016740]	identical protein binding [GO:0042802]; transferase activity [GO:0016740]; cell cycle [GO:0007049]; positive regulation of neuron differentiation [GO:0045666]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]	
Q695T7	reviewed	S6A19_HUMAN	Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1)	SLC6A19 B0AT1	Homo sapiens (Human)	634	FUNCTION: Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:15286787, PubMed:15286788, PubMed:18424768, PubMed:18484095, PubMed:19185582, PubMed:26240152). This uptake is sodium-dependent and chloride-independent (PubMed:15286787, PubMed:19185582, PubMed:15286788). Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:19185582, PubMed:18424768). {ECO:0000269|PubMed:15286787, ECO:0000269|PubMed:15286788, ECO:0000269|PubMed:18424768, ECO:0000269|PubMed:18484095, ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:26240152}.		amino acid transport [GO:0006865]; response to nutrient [GO:0007584]; sodium ion transmembrane transport [GO:0035725]; viral life cycle [GO:0019058]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; symporter activity [GO:0015293]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; symporter activity [GO:0015293]; amino acid transport [GO:0006865]; response to nutrient [GO:0007584]; sodium ion transmembrane transport [GO:0035725]; viral life cycle [GO:0019058]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:26240152}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:18424768}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with ACE2 on the apical membrane of cells lining villi of the jejunum, ileum and on kidney proximal tubules. {ECO:0000269|PubMed:18424768}.
Q69YG0	reviewed	TMM42_HUMAN	Transmembrane protein 42	TMEM42	Homo sapiens (Human)	159				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q69YH5	reviewed	CDCA2_HUMAN	Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man)	CDCA2	Homo sapiens (Human)	1023	FUNCTION: Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}.		cell division [GO:0051301]; chromosome segregation [GO:0007059]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of chromosome segregation [GO:0051983]; regulation of mitotic nuclear division [GO:0007088]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of chromosome segregation [GO:0051983]; regulation of mitotic nuclear division [GO:0007088]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16492807}. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
Q69YI7	reviewed	NAIF1_HUMAN	Nuclear apoptosis-inducing factor 1	NAIF1 C9orf90	Homo sapiens (Human)	327	FUNCTION: Induces apoptosis. {ECO:0000269|PubMed:16378748}.		negative regulation of cell growth [GO:0030308]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; negative regulation of cell growth [GO:0030308]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16378748, ECO:0000269|PubMed:18339812}.
Q69YN4	reviewed	VIR_HUMAN	Protein virilizer homolog	VIRMA KIAA1429 MSTP054	Homo sapiens (Human)	1812	FUNCTION: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}.		mRNA alternative polyadenylation [GO:0110104]; mRNA methylation [GO:0080009]; RNA splicing [GO:0008380]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	RNA binding [GO:0003723]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; RNA binding [GO:0003723]; mRNA alternative polyadenylation [GO:0110104]; mRNA methylation [GO:0080009]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:24100041}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24100041}. Cytoplasm {ECO:0000250|UniProtKB:A2AIV2}. Note=Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus. {ECO:0000250|UniProtKB:A2AIV2}.
Q69YQ0	reviewed	CYTSA_HUMAN	Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein)	SPECC1L CYTSA KIAA0376	Homo sapiens (Human)	1117	FUNCTION: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}.		actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; gap junction [GO:0005921]; microtubule organizing center [GO:0005815]; spindle [GO:0005819]		actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; gap junction [GO:0005921]; microtubule organizing center [GO:0005815]; spindle [GO:0005819]; actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21703590}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:21703590}. Cell junction, gap junction {ECO:0000269|PubMed:21703590}. Note=Colocalizes with acetylated alpha-tubulin, gamma-tubulin and F-actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center.
Q6A162	reviewed	K1C40_HUMAN	Keratin, type I cytoskeletal 40 (Cytokeratin-40) (CK-40) (Keratin-40) (K40) (Type I hair keratin Ka36)	KRT40 KA36	Homo sapiens (Human)	431	FUNCTION: May play a role in late hair differentiation.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
Q6A163	reviewed	K1C39_HUMAN	Keratin, type I cytoskeletal 39 (Cytokeratin-39) (CK-39) (Keratin-39) (K39) (Type I hair keratin Ka35)	KRT39 KA35	Homo sapiens (Human)	491	FUNCTION: May play a role in late hair differentiation.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
Q6AI14	reviewed	SL9A4_HUMAN	Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4)	SLC9A4 NHE4	Homo sapiens (Human)	798	FUNCTION: Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (By similarity). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (By similarity). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (By similarity). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (By similarity). {ECO:0000250|UniProtKB:P26434, ECO:0000250|UniProtKB:Q8BUE1}.		gastric acid secretion [GO:0001696]; glandular epithelial cell development [GO:0002068]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; transepithelial ammonium transport [GO:0070634]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]	potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; gastric acid secretion [GO:0001696]; glandular epithelial cell development [GO:0002068]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; transepithelial ammonium transport [GO:0070634]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:P26434}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q8BUE1}; Multi-pass membrane protein {ECO:0000255}. Zymogen granule membrane {ECO:0000250|UniProtKB:P26434}; Multi-pass membrane protein {ECO:0000255}. Note=Enrichment at apical or basolateral membrane may be tissue-dependent. {ECO:0000250|UniProtKB:P26434}.
Q6AI39	reviewed	BICRL_HUMAN	BRD4-interacting chromatin-remodeling complex-associated protein-like (Glioma tumor suppressor candidate region gene 1 protein-like)	BICRAL GLTSCR1L KIAA0240	Homo sapiens (Human)	1079	FUNCTION: Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. {ECO:0000269|PubMed:29374058}.		chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; SWI/SNF complex [GO:0016514]		chromatin [GO:0000785]; GBAF complex [GO:0140288]; SWI/SNF complex [GO:0016514]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q6AWC2	reviewed	WWC2_HUMAN	Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2)	WWC2 BOMB	Homo sapiens (Human)	1192			cell migration [GO:0016477]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; cell migration [GO:0016477]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330]	
Q6AZY7	reviewed	SCAR3_HUMAN	Scavenger receptor class A member 3 (Cellular stress response gene protein)	SCARA3 CSR	Homo sapiens (Human)	606	FUNCTION: Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation. {ECO:0000269|PubMed:9580669}.		response to oxidative stress [GO:0006979]; UV protection [GO:0009650]	collagen trimer [GO:0005581]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	scavenger receptor activity [GO:0005044]	collagen trimer [GO:0005581]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; scavenger receptor activity [GO:0005044]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9580669}; Single-pass type II membrane protein {ECO:0000269|PubMed:9580669}. Golgi apparatus membrane {ECO:0000269|PubMed:9580669}; Single-pass type II membrane protein {ECO:0000269|PubMed:9580669}. Note=Endoplasmic reticulum and/or Golgi.
Q6AZZ1	reviewed	TRI68_HUMAN	E3 ubiquitin-protein ligase TRIM68 (EC 2.3.2.27) (RING finger protein 137) (RING-type E3 ubiquitin transferase TRIM68) (SSA protein SS-56) (SS-56) (Tripartite motif-containing protein 68)	TRIM68 GC109 RNF137 SS56	Homo sapiens (Human)	485	FUNCTION: Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. {ECO:0000269|PubMed:18451177}.	MISCELLANEOUS: Antibodies against TRIM68 are found in patients with systemic lupus erythematosus (SLE) and primary Sjoegren syndrome.	innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein autoubiquitination [GO:0051865]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	histone acetyltransferase binding [GO:0035035]; identical protein binding [GO:0042802]; nuclear androgen receptor binding [GO:0050681]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; histone acetyltransferase binding [GO:0035035]; identical protein binding [GO:0042802]; nuclear androgen receptor binding [GO:0050681]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein autoubiquitination [GO:0051865]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus.
Q6B0I6	reviewed	KDM4D_HUMAN	Lysine-specific demethylase 4D (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3D) (Jumonji domain-containing protein 2D) ([histone H3]-trimethyl-L-lysine(9) demethylase 4D)	KDM4D JHDM3D JMJD2D	Homo sapiens (Human)	523	FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238}.		cellular response to ionizing radiation [GO:0071479]; chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of chromatin binding [GO:0035563]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; regulation of gene expression [GO:0010468]; regulation of protein phosphorylation [GO:0001932]	blood microparticle [GO:0072562]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of double-strand break [GO:0035861]	chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; histone demethylase activity [GO:0032452]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; metal ion binding [GO:0046872]	blood microparticle [GO:0072562]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of double-strand break [GO:0035861]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; histone demethylase activity [GO:0032452]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; metal ion binding [GO:0046872]; cellular response to ionizing radiation [GO:0071479]; chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of chromatin binding [GO:0035563]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; regulation of gene expression [GO:0010468]; regulation of protein phosphorylation [GO:0001932]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
Q6B8I1	reviewed	DS13A_HUMAN	Dual specificity protein phosphatase 13A (DUSP13A) (EC 3.1.3.16) (EC 3.1.3.48) (Branching-enzyme interacting DSP) (Muscle-restricted DSP) (MDSP)	DUSP13A BEDP DUSP13 MDSP	Homo sapiens (Human)	188	FUNCTION: Probable protein tyrosine phosphatase. Has phosphatase activity with synthetic substrates (PubMed:15252030, PubMed:29106959). Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1. {ECO:0000269|PubMed:15252030, ECO:0000269|PubMed:20358250, ECO:0000269|PubMed:29106959}.	MISCELLANEOUS: [Isoform 5]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	dephosphorylation [GO:0016311]	cytoplasm [GO:0005737]	myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; dephosphorylation [GO:0016311]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15252030}.
Q6BAA4	reviewed	FCRLB_HUMAN	Fc receptor-like B (Fc receptor homolog expressed in B-cells protein 2) (FREB-2) (Fc receptor-like and mucin-like protein 2) (Fc receptor-like protein 2) (Fc receptor-related protein Y) (FcRY)	FCRLB FCRL2 FCRLM2 FCRY FREB2	Homo sapiens (Human)	426			cell surface receptor signaling pathway [GO:0007166]; negative regulation of immune response [GO:0050777]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]	transmembrane signaling receptor activity [GO:0004888]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of immune response [GO:0050777]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15551350, ECO:0000269|PubMed:15676285, ECO:0000269|PubMed:15815692}. Endoplasmic reticulum {ECO:0000305|PubMed:15815692}. Note=Seems not to be secreted. {ECO:0000269|PubMed:15676285}.
Q6BCY4	reviewed	NB5R2_HUMAN	NADH-cytochrome b5 reductase 2 (b5R.2) (EC 1.6.2.2)	CYB5R2	Homo sapiens (Human)	276	FUNCTION: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1). {ECO:0000250, ECO:0000269|PubMed:15858218}.		bicarbonate transport [GO:0015701]; sterol biosynthetic process [GO:0016126]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; FAD binding [GO:0071949]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; FAD binding [GO:0071949]; bicarbonate transport [GO:0015701]; sterol biosynthetic process [GO:0016126]	
Q6BDI9	reviewed	REP15_HUMAN	Rab15 effector protein	REP15	Homo sapiens (Human)	236	FUNCTION: Regulates transferrin receptor recycling from the endocytic recycling compartment. {ECO:0000269|PubMed:16195351}.		receptor recycling [GO:0001881]; transferrin transport [GO:0033572]	early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]		early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; receptor recycling [GO:0001881]; transferrin transport [GO:0033572]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:16195351}. Note=Colocalizes with RAB11 and RAB15 to the endocytic recycling compartment.
Q6BDS2	reviewed	BLT3A_HUMAN	Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1)	BLTP3A C6orf107 UHRF1BP1	Homo sapiens (Human)	1440	FUNCTION: Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}.			late endosome [GO:0005770]	histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]	late endosome [GO:0005770]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:35499567}.
Q6DD88	reviewed	ATLA3_HUMAN	Atlastin-3 (EC 3.6.5.-)	ATL3	Homo sapiens (Human)	541	FUNCTION: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977). {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:27619977}.		endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; protein homooligomerization [GO:0051260]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; membrane [GO:0016020]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; membrane [GO:0016020]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:24459106, ECO:0000269|PubMed:27619977}; Multi-pass membrane protein {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:24459106}. Note=Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network. {ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:24459106, ECO:0000269|PubMed:27619977}.
Q6DHV7	reviewed	ADAL_HUMAN	Adenosine deaminase-like protein (EC 3.5.4.-) (Adenosine deaminase-like protein isoform 1) (N6-mAMP deaminase) (HsMAPDA) (N6-methyl-AMP aminohydrolase)	ADAL ADAL1	Homo sapiens (Human)	355	FUNCTION: Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine (PubMed:21755941, PubMed:29884623). Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A) (PubMed:21755941, PubMed:29884623). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro (PubMed:21755941). {ECO:0000269|PubMed:21755941, ECO:0000269|PubMed:29884623}.		adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103]; nucleotide metabolic process [GO:0009117]	cytosol [GO:0005829]	adenosine deaminase activity [GO:0004000]; metal ion binding [GO:0046872]; N6-methyl-AMP deaminase activity [GO:0062154]	cytosol [GO:0005829]; adenosine deaminase activity [GO:0004000]; metal ion binding [GO:0046872]; N6-methyl-AMP deaminase activity [GO:0062154]; adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103]; nucleotide metabolic process [GO:0009117]	
Q6DJT9	reviewed	PLAG1_HUMAN	Zinc finger protein PLAG1 (Pleiomorphic adenoma gene 1 protein)	PLAG1	Homo sapiens (Human)	500	FUNCTION: Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. {ECO:0000269|PubMed:11888928, ECO:0000269|PubMed:14695992, ECO:0000269|PubMed:14712223}.	MISCELLANEOUS: Residual nuclear import after mutation of the nuclear localization signal is assigned to zinc finger domains of PLAG1.; MISCELLANEOUS: When cultured cells transformed by PLAG1 overexpression are injected in nude mouse, rapidly growing tumors (fibrosarcomaS) are observed at the site of inoculation.	gland morphogenesis [GO:0022612]; multicellular organism growth [GO:0035264]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland growth [GO:0060736]; regulation of DNA-templated transcription [GO:0006355]	centrosome [GO:0005813]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	centrosome [GO:0005813]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; gland morphogenesis [GO:0022612]; multicellular organism growth [GO:0035264]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland growth [GO:0060736]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10646861, ECO:0000269|PubMed:11882654, ECO:0000269|PubMed:16207715}. Note=Strong nucleolar localization when sumoylation is inhibited.
Q6DKI2	reviewed	LEG9C_HUMAN	Galectin-9C (Gal-9C) (Galectin-9-like protein B)	LGALS9C	Homo sapiens (Human)	356	FUNCTION: Binds galactosides. {ECO:0000250}.	MISCELLANEOUS: The LGALS9-like proteins are encoded by a duplicated regions on chromosome 17; there are at least 3 genes coding for galectin-9-like proteins.	negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of type II interferon production [GO:0032689]; positive regulation of gene expression [GO:0010628]	cytosol [GO:0005829]; nucleus [GO:0005634]	carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936]	cytosol [GO:0005829]; nucleus [GO:0005634]; carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of type II interferon production [GO:0032689]; positive regulation of gene expression [GO:0010628]	
Q6DKI7	reviewed	PVRIG_HUMAN	Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein)	PVRIG C7orf15	Homo sapiens (Human)	326	FUNCTION: Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. {ECO:0000269|PubMed:26755705}.	MISCELLANEOUS: Was named PVRIG for the homology observed between its second exon and the variable immunoglobulin domain of the polio virus receptor (PVR/CD155) and polio virus receptor-like (PVRL) genes. {ECO:0000305|PubMed:16926269}.	negative regulation of T cell receptor signaling pathway [GO:0050860]	plasma membrane [GO:0005886]	phosphatase binding [GO:0019902]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; phosphatase binding [GO:0019902]; signaling receptor activity [GO:0038023]; negative regulation of T cell receptor signaling pathway [GO:0050860]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26755705}; Multi-pass membrane protein {ECO:0000305}.
Q6DKJ4	reviewed	NXN_HUMAN	Nucleoredoxin (EC 1.8.1.8)	NXN NRX	Homo sapiens (Human)	435	FUNCTION: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). {ECO:0000250|UniProtKB:P97346}.		cell differentiation [GO:0030154]; circulatory system development [GO:0072359]; in utero embryonic development [GO:0001701]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; nucleus [GO:0005634]	protein-disulfide reductase (NAD(P)) activity [GO:0047134]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]	cytosol [GO:0005829]; nucleus [GO:0005634]; protein-disulfide reductase (NAD(P)) activity [GO:0047134]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]; cell differentiation [GO:0030154]; circulatory system development [GO:0072359]; in utero embryonic development [GO:0001701]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P97346}. Nucleus {ECO:0000250|UniProtKB:P97346}.
Q6DKK2	reviewed	TTC19_HUMAN	Tetratricopeptide repeat protein 19, mitochondrial (TPR repeat protein 19)	TTC19	Homo sapiens (Human)	380	FUNCTION: Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1 (PubMed:21278747, PubMed:28673544). Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity (PubMed:28673544). {ECO:0000269|PubMed:21278747, ECO:0000269|PubMed:28673544}.		mitochondrial respiratory chain complex III assembly [GO:0034551]; mitotic cytokinesis [GO:0000281]	centrosome [GO:0005813]; midbody [GO:0030496]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respirasome [GO:0070469]		centrosome [GO:0005813]; midbody [GO:0030496]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respirasome [GO:0070469]; mitochondrial respiratory chain complex III assembly [GO:0034551]; mitotic cytokinesis [GO:0000281]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21278747}.
Q6DN03	reviewed	H2B2C_HUMAN	Putative histone H2B type 2-C (H2B-clustered histone 20 pseudogene) (Histone H2B.t) (H2B/t)	H2BC20P HIST2H2BC	Homo sapiens (Human)	193	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	MISCELLANEOUS: The mouse orthologous protein seems not to exist.		nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q6DN12	reviewed	MCTP2_HUMAN	Multiple C2 and transmembrane domain-containing protein 2	MCTP2	Homo sapiens (Human)	878	FUNCTION: Might play a role in the development of cardiac outflow tract. {ECO:0000269|PubMed:23773997}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	calcium-mediated signaling [GO:0019722]; regulation of neurotransmitter secretion [GO:0046928]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; calcium-mediated signaling [GO:0019722]; regulation of neurotransmitter secretion [GO:0046928]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6DN14	reviewed	MCTP1_HUMAN	Multiple C2 and transmembrane domain-containing protein 1	MCTP1	Homo sapiens (Human)	999	FUNCTION: Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. {ECO:0000250|UniProtKB:A1ZBD6}.		calcium-mediated signaling [GO:0019722]; negative regulation of cell migration [GO:0030336]; negative regulation of endocytosis [GO:0045806]; negative regulation of response to oxidative stress [GO:1902883]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of neurotransmitter secretion [GO:0046928]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; recycling endosome [GO:0055037]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; recycling endosome [GO:0055037]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; calcium-mediated signaling [GO:0019722]; negative regulation of cell migration [GO:0030336]; negative regulation of endocytosis [GO:0045806]; negative regulation of response to oxidative stress [GO:1902883]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of neurotransmitter secretion [GO:0046928]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:D4ABL6}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome {ECO:0000250|UniProtKB:D4ABL6}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A1ZBD6}.
Q6DN72	reviewed	FCRL6_HUMAN	Fc receptor-like protein 6 (FcR-like protein 6) (FcRL6) (Fc receptor homolog 6) (FcRH6) (IFGP6)	FCRL6 FCRH6	Homo sapiens (Human)	434	FUNCTION: Acts as a MHC class II receptor (PubMed:20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed:17213291, PubMed:18991291). Does not act as an Fc receptor (PubMed:18991291). {ECO:0000269|PubMed:17213291, ECO:0000269|PubMed:18991291, ECO:0000269|PubMed:20519654}.		cell surface receptor signaling pathway [GO:0007166]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	MHC class II protein binding [GO:0042289]; phosphatase binding [GO:0019902]; protein phosphatase binding [GO:0019903]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; MHC class II protein binding [GO:0042289]; phosphatase binding [GO:0019902]; protein phosphatase binding [GO:0019903]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18991291, ECO:0000269|PubMed:20933011}; Single-pass type I membrane protein {ECO:0000305}.
Q6DN90	reviewed	IQEC1_HUMAN	IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2)	IQSEC1 ARFGEP100 BRAG2 KIAA0763	Homo sapiens (Human)	963	FUNCTION: Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:24058294, PubMed:11226253). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}.		actin cytoskeleton organization [GO:0030036]; dendritic spine development [GO:0060996]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of keratinocyte migration [GO:0051549]; regulation of ARF protein signal transduction [GO:0032012]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021]	guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021]; guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289]; actin cytoskeleton organization [GO:0030036]; dendritic spine development [GO:0060996]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of keratinocyte migration [GO:0051549]; regulation of ARF protein signal transduction [GO:0032012]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11226253}. Nucleus {ECO:0000269|PubMed:11226253}. Postsynaptic density {ECO:0000250|UniProtKB:Q8R0S2}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q8R0S2}. Note=At steady state, may be preferentially cytosolic.
Q6DRA6	reviewed	H2B2D_HUMAN	Putative histone H2B type 2-D (H2B-clustered histone 19 pseudogene)	H2BC19P HIST2H2BD	Homo sapiens (Human)	164	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	MISCELLANEOUS: The mouse orthologous protein seems not to exist.		nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q6DT37	reviewed	MRCKG_HUMAN	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha)	CDC42BPG DMPK2	Homo sapiens (Human)	1551	FUNCTION: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}.		actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; protein phosphorylation [GO:0006468]	cell leading edge [GO:0031252]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell leading edge [GO:0031252]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15194684}. Note=Concentrates at the leading edge of cells.
Q6E0U4	reviewed	DMKN_HUMAN	Dermokine (Epidermis-specific secreted protein SK30/SK89)	DMKN UNQ729/PRO1411	Homo sapiens (Human)	476	FUNCTION: May act as a soluble regulator of keratinocyte differentiation. {ECO:0000305}.		cornified envelope assembly [GO:1903575]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; cornified envelope assembly [GO:1903575]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15234001}.
Q6E213	reviewed	AWAT2_HUMAN	Acyl-CoA wax alcohol acyltransferase 2 (EC 2.3.1.75) (11-cis-specific retinyl-ester synthase) (11-cis-RE-synthase) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diacylglycerol O-acyltransferase 2-like protein 4) (Diacylglycerol O-acyltransferase candidate 4) (hDC4) (Long-chain-alcohol O-fatty-acyltransferase 2) (Multifunctional O-acyltransferase) (Wax synthase) (hWS)	AWAT2 DC4 DGAT2L4 MFAT WS	Homo sapiens (Human)	333	FUNCTION: Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349, PubMed:15671038, PubMed:16106050, PubMed:28420705). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively (PubMed:15220349, PubMed:15671038). Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis-specific retinyl ester synthesis (PubMed:16106050, PubMed:24799687). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates (PubMed:24799687). {ECO:0000269|PubMed:15220349, ECO:0000269|PubMed:15671038, ECO:0000269|PubMed:16106050, ECO:0000269|PubMed:24799687, ECO:0000269|PubMed:28420705}.		acylglycerol acyl-chain remodeling [GO:0036155]; lipid metabolic process [GO:0006629]; monoacylglycerol biosynthetic process [GO:0006640]; retinoid metabolic process [GO:0001523]; wax biosynthetic process [GO:0010025]	endoplasmic reticulum membrane [GO:0005789]	2-acylglycerol O-acyltransferase activity [GO:0003846]; arachidoyl-CoA:1-dodecanol O-acyltransferase activity [GO:0102966]; long-chain-alcohol O-fatty-acyltransferase activity [GO:0047196]; retinol O-fatty-acyltransferase activity [GO:0050252]	endoplasmic reticulum membrane [GO:0005789]; 2-acylglycerol O-acyltransferase activity [GO:0003846]; arachidoyl-CoA:1-dodecanol O-acyltransferase activity [GO:0102966]; long-chain-alcohol O-fatty-acyltransferase activity [GO:0047196]; retinol O-fatty-acyltransferase activity [GO:0050252]; acylglycerol acyl-chain remodeling [GO:0036155]; lipid metabolic process [GO:0006629]; monoacylglycerol biosynthetic process [GO:0006640]; retinoid metabolic process [GO:0001523]; wax biosynthetic process [GO:0010025]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6E1M8}; Multi-pass membrane protein {ECO:0000255}.
Q6ECI4	reviewed	ZN470_HUMAN	Zinc finger protein 470 (Chondrogenesis zinc finger protein 1) (CZF-1)	ZNF470 CZF1	Homo sapiens (Human)	717	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15302581}.
Q6EEV6	reviewed	SUMO4_HUMAN	Small ubiquitin-related modifier 4 (SUMO-4) (Small ubiquitin-like protein 4)	SUMO4 SMT3H4	Homo sapiens (Human)	95	FUNCTION: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. {ECO:0000269|PubMed:15123604, ECO:0000269|PubMed:15247916, ECO:0000269|PubMed:16236267}.		cellular response to oxidative stress [GO:0034599]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA binding [GO:0043388]; protein sumoylation [GO:0016925]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of protein localization to nucleus [GO:1900180]	nucleus [GO:0005634]; SUMO ligase complex [GO:0106068]	protein tag activity [GO:0031386]; ubiquitin-like protein ligase binding [GO:0044389]	nucleus [GO:0005634]; SUMO ligase complex [GO:0106068]; protein tag activity [GO:0031386]; ubiquitin-like protein ligase binding [GO:0044389]; cellular response to oxidative stress [GO:0034599]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA binding [GO:0043388]; protein sumoylation [GO:0016925]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of protein localization to nucleus [GO:1900180]	
Q6EIG7	reviewed	CLC6A_HUMAN	C-type lectin domain family 6 member A (C-type lectin superfamily member 10) (Dendritic cell-associated C-type lectin 2) (DC-associated C-type lectin 2) (Dectin-2)	CLEC6A CLECSF10 DECTIN2	Homo sapiens (Human)	209	FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:23911656, PubMed:28652405). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (By similarity). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity). {ECO:0000250|UniProtKB:Q9JKF4, ECO:0000269|PubMed:23911656, ECO:0000269|PubMed:28652405}.		adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; defense response to fungus [GO:0050832]; detection of yeast [GO:0001879]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of T-helper 17 type immune response [GO:2000318]; response to yeast [GO:0001878]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; mannose binding [GO:0005537]; pattern recognition receptor activity [GO:0038187]; phospholipase binding [GO:0043274]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; mannose binding [GO:0005537]; pattern recognition receptor activity [GO:0038187]; phospholipase binding [GO:0043274]; adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; defense response to fungus [GO:0050832]; detection of yeast [GO:0001879]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of T-helper 17 type immune response [GO:2000318]; response to yeast [GO:0001878]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23911656}; Single-pass type II membrane protein {ECO:0000305}.
Q6EMB2	reviewed	TTLL5_HUMAN	Tubulin polyglutamylase TTLL5 (EC 6.3.2.-) (SRC1 and TIF2-associated modulatory protein) (STAMP protein) (Tubulin--tyrosine ligase-like protein 5)	TTLL5 KIAA0998 STAMP	Homo sapiens (Human)	1281	FUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules (PubMed:22493317). Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691). {ECO:0000250|UniProtKB:Q8CHB8, ECO:0000269|PubMed:17116691, ECO:0000269|PubMed:22493317}.		microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211]; retina development in camera-type eye [GO:0060041]	centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]; microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211]; retina development in camera-type eye [GO:0060041]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:24791901}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8CHB8}. Nucleus {ECO:0000269|PubMed:17116691}. Cytoplasm {ECO:0000269|PubMed:17116691}. Note=Localized to the base of the connecting cilium between the basal body and the adjacent daughter centriole of the cilium. In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid. {ECO:0000250|UniProtKB:Q8CHB8, ECO:0000269|PubMed:24791901}.
Q6EMK4	reviewed	VASN_HUMAN	Vasorin (Protein slit-like 2)	VASN SLITL2 UNQ314/PRO357/PRO1282	Homo sapiens (Human)	673	FUNCTION: May act as an inhibitor of TGF-beta signaling. {ECO:0000269|PubMed:15247411}.		cellular response to hypoxia [GO:0071456]; cellular response to redox state [GO:0071461]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; transforming growth factor beta binding [GO:0050431]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; transforming growth factor beta binding [GO:0050431]; cellular response to hypoxia [GO:0071456]; cellular response to redox state [GO:0071461]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:15247411}; Single-pass type I membrane protein {ECO:0000305|PubMed:15247411}. Secreted {ECO:0000269|PubMed:15247411}.
Q6F5E8	reviewed	CARL2_HUMAN	Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)	CARMIL2 LRRC16C RLTPR	Homo sapiens (Human)	1435	FUNCTION: Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647349, PubMed:27647348, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}.		actin filament network formation [GO:0051639]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of monopolar cell polarity [GO:0061339]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of cell migration [GO:0030335]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of ruffle assembly [GO:1900029]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; wound healing, spreading of cells [GO:0044319]	actin cytoskeleton [GO:0015629]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; macropinosome [GO:0044354]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	phospholipid binding [GO:0005543]; protein-containing complex binding [GO:0044877]	actin cytoskeleton [GO:0015629]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; macropinosome [GO:0044354]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; phospholipid binding [GO:0005543]; protein-containing complex binding [GO:0044877]; actin filament network formation [GO:0051639]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of monopolar cell polarity [GO:0061339]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of cell migration [GO:0030335]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of ruffle assembly [GO:1900029]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515}. Cell membrane {ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, lamellipodium {ECO:0000269|PubMed:26578515}. Cell projection, ruffle {ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515}. Note=Colocalizes to dynamic vimentin filaments both in the central cytoplasm and at leading edges of migrating cells (PubMed:26578515, PubMed:26466680, PubMed:19846667). Colocalizes with F-actin, Arp2/3 complex and cortactin to leading edge lamellipodia, ruffles and macropinosomes of migrating cells (PubMed:26578515). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515}.
Q6FHJ7	reviewed	SFRP4_HUMAN	Secreted frizzled-related protein 4 (sFRP-4) (Frizzled protein, human endometrium) (FrpHE)	SFRP4 FRPHE	Homo sapiens (Human)	346	FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927). {ECO:0000250|UniProtKB:Q9JLS4, ECO:0000250|UniProtKB:Q9Z1N6, ECO:0000269|PubMed:12952927}.		bone morphogenesis [GO:0060349]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of sodium-dependent phosphate transport [GO:2000119]; negative regulation of Wnt signaling pathway [GO:0030178]; non-canonical Wnt signaling pathway [GO:0035567]; phosphate ion homeostasis [GO:0055062]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte apoptotic process [GO:1902174]; positive regulation of receptor internalization [GO:0002092]; regulation of BMP signaling pathway [GO:0030510]; response to hormone [GO:0009725]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]	Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; Wnt-protein binding [GO:0017147]; bone morphogenesis [GO:0060349]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of sodium-dependent phosphate transport [GO:2000119]; negative regulation of Wnt signaling pathway [GO:0030178]; non-canonical Wnt signaling pathway [GO:0035567]; phosphate ion homeostasis [GO:0055062]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte apoptotic process [GO:1902174]; positive regulation of receptor internalization [GO:0002092]; regulation of BMP signaling pathway [GO:0030510]; response to hormone [GO:0009725]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19480240}. Note=Cytoplasmic in ovarian tumor cells.
Q6FI13	reviewed	H2A2A_HUMAN	Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o)	H2AC18 H2AFO HIST2H2AA HIST2H2AA3; H2AC19 HIST2H2AA4	Homo sapiens (Human)	130	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.			extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q6FI81	reviewed	CPIN1_HUMAN	Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog)	CIAPIN1 CUA001 PRO0915	Homo sapiens (Human)	312	FUNCTION: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}.	MISCELLANEOUS: 'Ana-mors-in' means 'anti-death molecule' in Latin.	apoptotic process [GO:0006915]; hemopoiesis [GO:0030097]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of apoptotic process [GO:0043066]	cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; apoptotic process [GO:0006915]; hemopoiesis [GO:0030097]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of apoptotic process [GO:0043066]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:16957168, ECO:0000269|PubMed:29848660}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:16957168}. Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:21700214}.
Q6FIF0	reviewed	ZFAN6_HUMAN	AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3)	ZFAND6 AWP1 ZA20D3 HT032	Homo sapiens (Human)	208	FUNCTION: Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity). {ECO:0000250, ECO:0000269|PubMed:19285159, ECO:0000269|PubMed:21810480}.		apoptotic process [GO:0006915]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; protein targeting to peroxisome [GO:0006625]; regulation of canonical NF-kappaB signal transduction [GO:0043122]	cytosol [GO:0005829]	DNA binding [GO:0003677]; polyubiquitin modification-dependent protein binding [GO:0031593]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; DNA binding [GO:0003677]; polyubiquitin modification-dependent protein binding [GO:0031593]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; protein targeting to peroxisome [GO:0006625]; regulation of canonical NF-kappaB signal transduction [GO:0043122]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q6GMR7	reviewed	FAAH2_HUMAN	Fatty-acid amide hydrolase 2 (EC 3.5.1.99) (Amidase domain-containing protein) (Anandamide amidohydrolase 2) (Oleamide hydrolase 2)	FAAH2 AMDD	Homo sapiens (Human)	532	FUNCTION: Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates. {ECO:0000269|PubMed:17015445, ECO:0000269|PubMed:19926788}.		arachidonic acid metabolic process [GO:0019369]; lipid catabolic process [GO:0016042]	lipid droplet [GO:0005811]; membrane [GO:0016020]	fatty acid amide hydrolase activity [GO:0017064]	lipid droplet [GO:0005811]; membrane [GO:0016020]; fatty acid amide hydrolase activity [GO:0017064]; arachidonic acid metabolic process [GO:0019369]; lipid catabolic process [GO:0016042]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:17015445}; Single-pass membrane protein {ECO:0000305}. Lipid droplet {ECO:0000269|PubMed:19926788}.
Q6GMV2	reviewed	SMYD5_HUMAN	Histone-lysine N-trimethyltransferase SMYD5 (EC 2.1.1.372) (Protein NN8-4AG) (Retinoic acid-induced protein 15) (SET and MYND domain-containing protein 5) ([histone H4]-lysine20 N-trimethyltransferase SMYD5)	SMYD5 RAI15	Homo sapiens (Human)	418	FUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression (By similarity). In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters (By similarity). Plays an important role in embryonic stem (ES) cell self-renewal and differentiation (By similarity). Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks (By similarity). Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks (PubMed:28951459). {ECO:0000250|UniProtKB:Q3TYX3, ECO:0000269|PubMed:28951459}.		methylation [GO:0032259]; negative regulation of gene expression, epigenetic [GO:0045814]; regulation of stem cell differentiation [GO:2000736]; regulation of stem cell division [GO:2000035]; retrotransposon silencing by heterochromatin formation [GO:0141005]		histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 trimethyltransferase activity [GO:0140943]; metal ion binding [GO:0046872]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 trimethyltransferase activity [GO:0140943]; metal ion binding [GO:0046872]; methylation [GO:0032259]; negative regulation of gene expression, epigenetic [GO:0045814]; regulation of stem cell differentiation [GO:2000736]; regulation of stem cell division [GO:2000035]; retrotransposon silencing by heterochromatin formation [GO:0141005]	
Q6GPH4	reviewed	XAF1_HUMAN	XIAP-associated factor 1 (BIRC4-binding protein)	XAF1 BIRC4BP XIAPAF1	Homo sapiens (Human)	301	FUNCTION: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. {ECO:0000269|PubMed:11175744, ECO:0000269|PubMed:12029096, ECO:0000269|PubMed:16432762, ECO:0000269|PubMed:17329253, ECO:0000269|PubMed:17613533}.		apoptotic process [GO:0006915]; negative regulation of type I interferon production [GO:0032480]; response to interferon-beta [GO:0035456]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	molecular sequestering activity [GO:0140313]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; molecular sequestering activity [GO:0140313]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; negative regulation of type I interferon production [GO:0032480]; response to interferon-beta [GO:0035456]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion. Note=Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus.
Q6GQQ9	reviewed	OTU7B_HUMAN	OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)	OTUD7B ZA20D1	Homo sapiens (Human)	843	FUNCTION: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin. {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:27732584}.		adaptive immune response [GO:0002250]; in utero embryonic development [GO:0001701]; mucosal immune response [GO:0002385]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; DNA binding [GO:0003677]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; DNA binding [GO:0003677]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270]; adaptive immune response [GO:0002250]; in utero embryonic development [GO:0001701]; mucosal immune response [GO:0002385]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:21888622}. Nucleus {ECO:0000269|PubMed:21888622}. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner. {ECO:0000269|PubMed:21888622}.
Q6GTS8	reviewed	P20D1_HUMAN	N-fatty-acyl-amino acid synthase/hydrolase PM20D1 (EC 3.5.1.114) (EC 3.5.1.14) (Peptidase M20 domain-containing protein 1)	PM20D1	Homo sapiens (Human)	502	FUNCTION: Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase (PubMed:27374330). It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction (PubMed:27374330). Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles (By similarity). {ECO:0000250|UniProtKB:Q8C165, ECO:0000269|PubMed:27374330}.	MISCELLANEOUS: Genetically increasing or decreasing the expression of PM20D1 reduces and aggravates Alzheimer's disease (AD) related pathologies, respectively. These findings suggest that in a particular genetic background, PM20D1 contributes to neuroprotection against AD. {ECO:0000269|PubMed:29736028}.	adaptive thermogenesis [GO:1990845]; amide biosynthetic process [GO:0043604]; amide catabolic process [GO:0043605]; amino acid metabolic process [GO:0006520]; cellular lipid metabolic process [GO:0044255]; energy homeostasis [GO:0097009]; fatty acid metabolic process [GO:0006631]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	aminoacylase activity [GO:0004046]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]; peptidase activity [GO:0008233]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; aminoacylase activity [GO:0004046]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]; peptidase activity [GO:0008233]; adaptive thermogenesis [GO:1990845]; amide biosynthetic process [GO:0043604]; amide catabolic process [GO:0043605]; amino acid metabolic process [GO:0006520]; cellular lipid metabolic process [GO:0044255]; energy homeostasis [GO:0097009]; fatty acid metabolic process [GO:0006631]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8C165}.
Q6GTX8	reviewed	LAIR1_HUMAN	Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305)	LAIR1 CD305	Homo sapiens (Human)	287	FUNCTION: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:10764762, ECO:0000269|PubMed:11069054, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:12072189, ECO:0000269|PubMed:15939744, ECO:0000269|PubMed:15950745, ECO:0000269|PubMed:16380958, ECO:0000269|PubMed:9285412, ECO:0000269|PubMed:9692876}.	MISCELLANEOUS: [Isoform 2]: Functions as an inhibitory receptor in NK cells and T-cells. {ECO:0000305}.	adaptive immune response [GO:0002250]	plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]		plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:9285412}; Single-pass type I membrane protein {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:9285412}.
Q6GYQ0	reviewed	RGPA1_HUMAN	Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240)	RALGAPA1 GARNL1 KIAA0884 TULIP1	Homo sapiens (Human)	2036	FUNCTION: Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.		activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982]; activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocated to the nucleus, when associated with TCF3/E12. {ECO:0000250}.
Q6H3X3	reviewed	ULBP5_HUMAN	UL-16 binding protein 5 (Retinoic acid early transcript 1G protein)	RAET1G ULBP5	Homo sapiens (Human)	334	FUNCTION: [Isoform 1]: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:18544572, ECO:0000269|PubMed:19658097}.; FUNCTION: [Isoform 3]: Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG. {ECO:0000269|PubMed:18544572}.; FUNCTION: [Isoform 2]: Stimulates natural killer cells to secrete IFNG. {ECO:0000269|PubMed:18544572}.	MISCELLANEOUS: UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain. {ECO:0000305}.	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	natural killer cell lectin-like receptor binding [GO:0046703]	endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; natural killer cell lectin-like receptor binding [GO:0046703]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:19223974, ECO:0000269|PubMed:20304922}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:20304922}. Endoplasmic reticulum {ECO:0000269|PubMed:19223974, ECO:0000269|PubMed:20304922}. Note=Mainly found intracellularly. {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:19223974, ECO:0000269|PubMed:20304922}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:19223974}.
Q6H8Q1	reviewed	ABLM2_HUMAN	Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2)	ABLIM2 KIAA1808	Homo sapiens (Human)	611	FUNCTION: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}.		cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]	actin filament binding [GO:0051015]; metal ion binding [GO:0046872]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; actin filament binding [GO:0051015]; metal ion binding [GO:0046872]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]	SUBCELLULAR LOCATION: Cytoplasm. Note=In skeletal muscle, sarcomeric or cosarcomeric localization. {ECO:0000250}.
Q6HA08	reviewed	ASTL_HUMAN	Astacin-like metalloendopeptidase (EC 3.4.-.-) (Oocyte astacin) (Ovastacin) (ZP2-proteinase)	ASTL	Homo sapiens (Human)	431	FUNCTION: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding. {ECO:0000250|UniProtKB:Q6HA09}.		cell adhesion [GO:0007155]; fertilization [GO:0009566]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; positive regulation of protein processing [GO:0010954]; prevention of polyspermy [GO:0060468]; proteolysis [GO:0006508]	cortical granule [GO:0060473]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	aspartic-type peptidase activity [GO:0070001]; glutamic-type peptidase activity [GO:0070002]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	cortical granule [GO:0060473]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; aspartic-type peptidase activity [GO:0070001]; glutamic-type peptidase activity [GO:0070002]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; cell adhesion [GO:0007155]; fertilization [GO:0009566]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; positive regulation of protein processing [GO:0010954]; prevention of polyspermy [GO:0060468]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6HA09}. Cell membrane {ECO:0000250|UniProtKB:Q6HA09}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q6HA09}. Note=Probably exocytosed from cortical granules during post-fertilization. Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles at postnatal (PN) day 3. Detected in the microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior to fertilization. Upon fertilization, detected in the perivitelline space (PVS) and occasionally on the oolemma in 2-cell through morulae stages. Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the perivitelline space (PVS). {ECO:0000250|UniProtKB:Q6HA09}.
Q6I9Y2	reviewed	THOC7_HUMAN	THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30)	THOC7 NIF3L1BP1	Homo sapiens (Human)	204	FUNCTION: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:23222130}.; FUNCTION: The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}.		mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; viral mRNA export from host cell nucleus [GO:0046784]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; viral mRNA export from host cell nucleus [GO:0046784]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12951069}. Nucleus {ECO:0000269|PubMed:12951069, ECO:0000269|PubMed:19059247}. Nucleus speckle {ECO:0000305}. Note=Interaction with THOC5 is required for nuclear localization. {ECO:0000269|PubMed:19059247}.
Q6IA17	reviewed	SIGIR_HUMAN	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)	SIGIRR UNQ301/PRO342	Homo sapiens (Human)	410	FUNCTION: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:15866876, ECO:0000269|PubMed:25963006}.		acute-phase response [GO:0006953]; negative regulation of chemokine production [GO:0032682]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; signal transduction [GO:0007165]	membrane [GO:0016020]; plasma membrane [GO:0005886]		membrane [GO:0016020]; plasma membrane [GO:0005886]; acute-phase response [GO:0006953]; negative regulation of chemokine production [GO:0032682]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Q6IA69	reviewed	NADE_HUMAN	Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase)	NADSYN1	Homo sapiens (Human)	706	FUNCTION: Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source. {ECO:0000269|PubMed:12547821, ECO:0000269|PubMed:31883644}.		'de novo' NAD biosynthetic process [GO:0034627]; NAD biosynthetic process [GO:0009435]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; glutaminase activity [GO:0004359]; NAD+ synthase (glutamine-hydrolyzing) activity [GO:0003952]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; glutaminase activity [GO:0004359]; NAD+ synthase (glutamine-hydrolyzing) activity [GO:0003952]; 'de novo' NAD biosynthetic process [GO:0034627]; NAD biosynthetic process [GO:0009435]	
Q6IA86	reviewed	ELP2_HUMAN	Elongator complex protein 2 (ELP2) (SHINC-2) (STAT3-interacting protein 1) (StIP1)	ELP2 STATIP1	Homo sapiens (Human)	826	FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). {ECO:0000303|PubMed:29332244}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; transcription elongation by RNA polymerase II [GO:0006368]; tRNA wobble uridine modification [GO:0002098]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]	protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]; protein kinase binding [GO:0019901]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; transcription elongation by RNA polymerase II [GO:0006368]; tRNA wobble uridine modification [GO:0002098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576}. Nucleus {ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576}.
Q6IAA8	reviewed	LTOR1_HUMAN	Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho)	LAMTOR1 C11orf59 PDRO PP7157	Homo sapiens (Human)	161	FUNCTION: Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874, PubMed:29158492, PubMed:28935770). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:29285400, PubMed:29107538, PubMed:29123114, PubMed:28935770). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}.		cellular response to amino acid stimulus [GO:0071230]; cellular response to nutrient levels [GO:0031669]; cholesterol homeostasis [GO:0042632]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein localization to lysosome [GO:0150032]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; protein localization to membrane [GO:0072657]; regulation of cell growth [GO:0001558]; regulation of cholesterol efflux [GO:0010874]; regulation of cholesterol import [GO:0060620]; regulation of receptor recycling [GO:0001919]; TORC1 signaling [GO:0038202]	azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; Ragulator complex [GO:0071986]; specific granule membrane [GO:0035579]	GTPase binding [GO:0051020]; protein-membrane adaptor activity [GO:0043495]	azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; Ragulator complex [GO:0071986]; specific granule membrane [GO:0035579]; GTPase binding [GO:0051020]; protein-membrane adaptor activity [GO:0043495]; cellular response to amino acid stimulus [GO:0071230]; cellular response to nutrient levels [GO:0031669]; cholesterol homeostasis [GO:0042632]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein localization to lysosome [GO:0150032]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; protein localization to membrane [GO:0072657]; regulation of cell growth [GO:0001558]; regulation of cholesterol efflux [GO:0010874]; regulation of cholesterol import [GO:0060620]; regulation of receptor recycling [GO:0001919]; TORC1 signaling [GO:0038202]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:32686708}; Lipid-anchor {ECO:0000269|PubMed:31001086}; Cytoplasmic side {ECO:0000269|PubMed:31001086}. Late endosome membrane {ECO:0000269|PubMed:20544018}; Lipid-anchor {ECO:0000269|PubMed:31001086}; Cytoplasmic side {ECO:0000269|PubMed:31001086}. Note=Recruited to lysosome and endosome membranes through N-terminal myristoylation and palmitoylation. {ECO:0000269|PubMed:31001086}.
Q6IAN0	reviewed	DRS7B_HUMAN	Dehydrogenase/reductase SDR family member 7B (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 32C member 1) (Protein SDR32C1)	DHRS7B SDR32C1 CGI-93 UNQ212/PRO238	Homo sapiens (Human)	325	FUNCTION: Putative oxidoreductase. {ECO:0000305}.		adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; ether lipid biosynthetic process [GO:0008611]; inflammatory response [GO:0006954]; neutrophil differentiation [GO:0030223]; phosphatidylcholine biosynthetic process [GO:0006656]; regulation of cold-induced thermogenesis [GO:0120161]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; transcription regulator complex [GO:0005667]	acylglycerone-phosphate reductase activity [GO:0000140]; DNA-binding transcription factor binding [GO:0140297]; transcription corepressor activity [GO:0003714]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; transcription regulator complex [GO:0005667]; acylglycerone-phosphate reductase activity [GO:0000140]; DNA-binding transcription factor binding [GO:0140297]; transcription corepressor activity [GO:0003714]; adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; ether lipid biosynthetic process [GO:0008611]; inflammatory response [GO:0006954]; neutrophil differentiation [GO:0030223]; phosphatidylcholine biosynthetic process [GO:0006656]; regulation of cold-induced thermogenesis [GO:0120161]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5RJY4}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q5RJY4}.
Q6IB77	reviewed	GLYAT_HUMAN	Glycine N-acyltransferase (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase) (AAc) (Aralkyl acyl-CoA N-acyltransferase) (Aralkyl acyl-CoA:amino acid N-acyltransferase) (Benzoyl-coenzyme A:glycine N-acyltransferase) (Glycine N-benzoyltransferase) (EC 2.3.1.71) (HRP-1(CLP))	GLYAT ACGNAT CAT GAT	Homo sapiens (Human)	296	FUNCTION: Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. {ECO:0000269|PubMed:22475485, ECO:0000269|PubMed:7802672}.		acyl-CoA metabolic process [GO:0006637]; benzoyl-CoA metabolic process [GO:1901787]; glycine metabolic process [GO:0006544]; monocarboxylic acid metabolic process [GO:0032787]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	acyltransferase activity [GO:0016746]; glycine N-acyltransferase activity [GO:0047961]; glycine N-benzoyltransferase activity [GO:0047962]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; acyltransferase activity [GO:0016746]; glycine N-acyltransferase activity [GO:0047961]; glycine N-benzoyltransferase activity [GO:0047962]; acyl-CoA metabolic process [GO:0006637]; benzoyl-CoA metabolic process [GO:1901787]; glycine metabolic process [GO:0006544]; monocarboxylic acid metabolic process [GO:0032787]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22475485}.
Q6IBS0	reviewed	TWF2_HUMAN	Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein)	TWF2 PTK9L MSTP011	Homo sapiens (Human)	349	FUNCTION: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}.		actin filament depolymerization [GO:0030042]; barbed-end actin filament capping [GO:0051016]; cell projection organization [GO:0030030]; cellular response to growth factor stimulus [GO:0071363]; cellular response to retinoic acid [GO:0071300]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of axon extension [GO:0045773]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of lamellipodium assembly [GO:0010591]; regulation of microvillus length [GO:0032532]; sequestering of actin monomers [GO:0042989]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; myofibril [GO:0030016]; perinuclear region of cytoplasm [GO:0048471]; stereocilium [GO:0032420]	actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; myofibril [GO:0030016]; perinuclear region of cytoplasm [GO:0048471]; stereocilium [GO:0032420]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; actin filament depolymerization [GO:0030042]; barbed-end actin filament capping [GO:0051016]; cell projection organization [GO:0030030]; cellular response to growth factor stimulus [GO:0071363]; cellular response to retinoic acid [GO:0071300]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of axon extension [GO:0045773]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of lamellipodium assembly [GO:0010591]; regulation of microvillus length [GO:0032532]; sequestering of actin monomers [GO:0042989]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10406962}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10406962}. Cell projection, stereocilium {ECO:0000250}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization.
Q6IBW4	reviewed	CNDH2_HUMAN	Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2)	NCAPH2 CAPH2	Homo sapiens (Human)	605	FUNCTION: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}.		female meiosis chromosome separation [GO:0051309]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; mitotic sister chromatid separation [GO:0051306]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; T cell differentiation in thymus [GO:0033077]	cell junction [GO:0030054]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	cell junction [GO:0030054]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; female meiosis chromosome separation [GO:0051309]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; mitotic sister chromatid separation [GO:0051306]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; T cell differentiation in thymus [GO:0033077]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14532007}. Chromosome {ECO:0000269|PubMed:14532007}. Note=Distributed along the arms of chromosomes assembled in vivo and in vitro.
Q6IC98	reviewed	GRAM4_HUMAN	GRAM domain-containing protein 4 (Death-inducing protein)	GRAMD4 DIP KIAA0767	Homo sapiens (Human)	578	FUNCTION: Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177). Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity). {ECO:0000250|UniProtKB:Q8CB44, ECO:0000269|PubMed:15565177}.		apoptotic process [GO:0006915]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]	endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]		endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; apoptotic process [GO:0006915]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8CB44}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with COX4I1. {ECO:0000269|PubMed:15565177}.
Q6ICB0	reviewed	DESI1_HUMAN	Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Polyubiquitinated substrate transporter) (POST)	DESI1 FAM152B PPPDE2	Homo sapiens (Human)	168	FUNCTION: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). {ECO:0000250|UniProtKB:Q9CQT7, ECO:0000269|PubMed:29666234}.		protein export from nucleus [GO:0006611]; proteolysis [GO:0006508]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]	cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	deSUMOylase activity [GO:0016929]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]	cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; deSUMOylase activity [GO:0016929]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]; protein export from nucleus [GO:0006611]; proteolysis [GO:0006508]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29666234}. Nucleus {ECO:0000269|PubMed:29666234}. Note=Shuttles between the nucleus and the cytoplasm; exported from the nucleus in a XPO1/CRM1-dependent manner via its nuclear export signal motifs. {ECO:0000269|PubMed:29666234}.
Q6ICB4	reviewed	SESQ2_HUMAN	Sesquipedalian-2 (Ses2) (27 kDa inositol polyphosphate phosphatase interacting protein B) (IPIP27B) (PH domain-containing endocytic trafficking adaptor 2)	PHETA2 FAM109B	Homo sapiens (Human)	259	FUNCTION: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. {ECO:0000269|PubMed:21233288}.	MISCELLANEOUS: Was named after 'sesquipedalian', an unnecessarily long description of a simple thing. {ECO:0000305|PubMed:20133602}.	endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]	protein homodimerization activity [GO:0042803]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; protein homodimerization activity [GO:0042803]; endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:21233288}. Recycling endosome {ECO:0000269|PubMed:21233288}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:21233288}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:21233288}. Note=Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes. {ECO:0000269|PubMed:20133602, ECO:0000269|PubMed:21233288}.
Q6ICG8	reviewed	WBP2L_HUMAN	Postacrosomal sheath WW domain-binding protein (WW domain-binding protein 2-like)	WBP2NL PAWP	Homo sapiens (Human)	309	FUNCTION: May play a role in meiotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization. {ECO:0000250}.		egg activation [GO:0007343]; male pronucleus assembly [GO:0035039]; meiotic cell cycle [GO:0051321]; positive regulation of DNA-templated transcription [GO:0045893]	nucleus [GO:0005634]; perinuclear theca [GO:0033011]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]	chromatin DNA binding [GO:0031490]; transcription coactivator activity [GO:0003713]; WW domain binding [GO:0050699]	nucleus [GO:0005634]; perinuclear theca [GO:0033011]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; chromatin DNA binding [GO:0031490]; transcription coactivator activity [GO:0003713]; WW domain binding [GO:0050699]; egg activation [GO:0007343]; male pronucleus assembly [GO:0035039]; meiotic cell cycle [GO:0051321]; positive regulation of DNA-templated transcription [GO:0045893]	
Q6ICL3	reviewed	TNG2_HUMAN	Transport and Golgi organization protein 2 homolog	TANGO2 C22orf25	Homo sapiens (Human)	276	FUNCTION: May be involved in lipid homeostasis. {ECO:0000269|PubMed:36961129}.		Golgi organization [GO:0007030]; protein secretion [GO:0009306]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; Golgi organization [GO:0007030]; protein secretion [GO:0009306]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31276219, ECO:0000269|PubMed:32909282, ECO:0000269|PubMed:36961129}. Mitochondrion {ECO:0000269|PubMed:32909282, ECO:0000269|PubMed:35197517, ECO:0000269|PubMed:36961129}. Golgi apparatus {ECO:0000269|PubMed:26805781}. Note=Localizes predominantly to mitochondrion. Deteted in close proximity to endoplasmic reticulum and lipid droplets. {ECO:0000269|PubMed:36961129}.
Q6ICL7	reviewed	S35E4_HUMAN	Solute carrier family 35 member E4	SLC35E4	Homo sapiens (Human)	350	FUNCTION: Putative transporter. {ECO:0000250}.			Golgi apparatus [GO:0005794]; membrane [GO:0016020]	antiporter activity [GO:0015297]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; antiporter activity [GO:0015297]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6IE81	reviewed	JADE1_HUMAN	Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17)	JADE1 KIAA1807 PHF17	Homo sapiens (Human)	842	FUNCTION: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:16046545, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22654112, ECO:0000269|PubMed:24065767}.		apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:22654112}. Chromosome {ECO:0000269|PubMed:19187766}. Cytoplasm {ECO:0000269|PubMed:12169691, ECO:0000269|PubMed:15502158}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22654112}. Note=Localizes to the ciliary transition zone. {ECO:0000269|PubMed:22654112}.
Q6IEG0	reviewed	SNR48_HUMAN	U11/U12 small nuclear ribonucleoprotein 48 kDa protein (U11/U12 snRNP 48 kDa protein) (U11/U12-48K)	SNRNP48 C6orf151	Homo sapiens (Human)	339	FUNCTION: Likely involved in U12-type 5' splice site recognition. {ECO:0000269|PubMed:19217400}.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689]	metal ion binding [GO:0046872]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689]; metal ion binding [GO:0046872]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15146077}.
Q6IMI6	reviewed	ST1C3_HUMAN	Sulfotransferase 1C3 (ST1C3) (EC 2.8.2.1) (EC 2.8.2.2)	SULT1C3	Homo sapiens (Human)	304	FUNCTION: [Isoform 1]: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor. Has sulfotransferase activity towards various substrates, such as bile acids, thyroid hormones and toward xenobiotic compounds such as chloro phenols and hydroxypyrenes. Lithocholic acid appears to be the best substrate among the endogenous compounds tested and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol shows the highest specific activity among the xenobiotic compounds. {ECO:0000269|PubMed:17425406, ECO:0000269|PubMed:17936463, ECO:0000269|PubMed:28992322}.; FUNCTION: [Isoform 2]: Exhibits weak sulphating activity and only toward chloro phenols (pentachlorophenol and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol). {ECO:0000269|PubMed:28992322}.	MISCELLANEOUS: SULT1C3 gene appears to be present only in humans and other primates. {ECO:0000305|PubMed:28992322}.	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; sulfation [GO:0051923]; sulfur compound metabolic process [GO:0006790]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]	3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; alcohol sulfotransferase activity [GO:0004027]; aryl sulfotransferase activity [GO:0004062]; bile-salt sulfotransferase activity [GO:0047704]	cytoplasm [GO:0005737]; 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; alcohol sulfotransferase activity [GO:0004027]; aryl sulfotransferase activity [GO:0004062]; bile-salt sulfotransferase activity [GO:0047704]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; sulfation [GO:0051923]; sulfur compound metabolic process [GO:0006790]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q80VR3}.
Q6IMN6	reviewed	CAPR2_HUMAN	Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140)	CAPRIN2 C1QDC1 EEG1 KIAA1873 RNG140	Homo sapiens (Human)	1127	FUNCTION: Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112). {ECO:0000250|UniProtKB:Q05A80, ECO:0000269|PubMed:14593112, ECO:0000269|PubMed:18762581, ECO:0000269|PubMed:27821587}.		cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion. Cytoplasm. Note=Expressed throughout the cytoplasm.; SUBCELLULAR LOCATION: [Isoform 5]: Mitochondrion. Note=Colocalizes with aggregated mitochondria.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:27821587}; Peripheral membrane protein {ECO:0000305}.
Q6IN84	reviewed	MRM1_HUMAN	rRNA methyltransferase 1, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1145)-2'-O)-methyltransferase) (16S rRNA [Gm1145] 2'-O-methyltransferase)	MRM1	Homo sapiens (Human)	353	FUNCTION: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. {ECO:0000269|PubMed:25074936}.		rRNA 2'-O-methylation [GO:0000451]; rRNA modification [GO:0000154]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; rRNA (guanine) methyltransferase activity [GO:0016435]; rRNA (guanosine-2'-O-)-methyltransferase activity [GO:0070039]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; rRNA (guanine) methyltransferase activity [GO:0016435]; rRNA (guanosine-2'-O-)-methyltransferase activity [GO:0070039]; rRNA 2'-O-methylation [GO:0000451]; rRNA modification [GO:0000154]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:24036117, ECO:0000269|PubMed:25009282, ECO:0000269|PubMed:27184847}.
Q6IN85	reviewed	P4R3A_HUMAN	Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1)	PPP4R3A KIAA2010 PP4R3A SMEK1 MSTP033	Homo sapiens (Human)	833	FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}.		DNA damage response [GO:0006974]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein phosphatase 4 complex [GO:0030289]	protein phosphatase activator activity [GO:0072542]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein phosphatase 4 complex [GO:0030289]; protein phosphatase activator activity [GO:0072542]; DNA damage response [GO:0006974]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18487071}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18487071}. Nucleus {ECO:0000269|PubMed:18487071}. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.
Q6IPM2	reviewed	IQCE_HUMAN	IQ domain-containing protein E	IQCE KIAA1023	Homo sapiens (Human)	695	FUNCTION: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). {ECO:0000250|UniProtKB:Q6PCQ0, ECO:0000269|PubMed:28488682}.		limb morphogenesis [GO:0035108]	ciliary membrane [GO:0060170]; cilium [GO:0005929]		ciliary membrane [GO:0060170]; cilium [GO:0005929]; limb morphogenesis [GO:0035108]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q6PCQ0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6PCQ0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6PCQ0}. Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner. {ECO:0000250|UniProtKB:Q6PCQ0}.
Q6IPU0	reviewed	CENPP_HUMAN	Centromere protein P (CENP-P)	CENPP	Homo sapiens (Human)	288	FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:16622420}.		CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]	cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16622420}. Chromosome, centromere {ECO:0000269|PubMed:16622420}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Q6IQ16	reviewed	SPOPL_HUMAN	Speckle-type POZ protein-like (HIB homolog 2) (Roadkill homolog 2)	SPOPL	Homo sapiens (Human)	392	FUNCTION: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. {ECO:0000269|PubMed:22632832}.		negative regulation of protein ubiquitination [GO:0031397]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of proteolysis [GO:0030162]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	ubiquitin protein ligase binding [GO:0031625]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin protein ligase binding [GO:0031625]; negative regulation of protein ubiquitination [GO:0031397]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of proteolysis [GO:0030162]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q6IQ19	reviewed	CCSAP_HUMAN	Centriole, cilia and spindle-associated protein	CCSAP C1orf96 CSAP	Homo sapiens (Human)	270	FUNCTION: Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating (By similarity). {ECO:0000250|UniProtKB:Q6P3G4, ECO:0000269|PubMed:26562023}.		cell cycle [GO:0007049]; cell division [GO:0051301]; mitotic spindle microtubule depolymerization [GO:1990755]; regulation of embryonic development [GO:0045995]; regulation of mitotic spindle assembly [GO:1901673]	axon [GO:0030424]; axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; mitotic spindle [GO:0072686]; mitotic spindle astral microtubule [GO:0061673]; spindle [GO:0005819]	microtubule binding [GO:0008017]	axon [GO:0030424]; axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; mitotic spindle [GO:0072686]; mitotic spindle astral microtubule [GO:0061673]; spindle [GO:0005819]; microtubule binding [GO:0008017]; cell cycle [GO:0007049]; cell division [GO:0051301]; mitotic spindle microtubule depolymerization [GO:1990755]; regulation of embryonic development [GO:0045995]; regulation of mitotic spindle assembly [GO:1901673]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22493317}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:22493317, ECO:0000269|PubMed:26562023}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22493317}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22493317}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:22493317}. Cell projection, axon {ECO:0000269|PubMed:22493317}. Cell projection, cilium {ECO:0000269|PubMed:22493317}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:26562023}. Note=Localizes to two to four centrioles throughout the cell cycle. Localizes to mitotic spindle microtubules during prometaphase and throughout the remainder of mitosis. Localizes to cytoskeleton on interphase. Localizes at the ciliary transition zone which connects the basal bodies to ciliary microtubules. Colocalizes with polyglutamylated tubulin. {ECO:0000269|PubMed:22493317, ECO:0000269|PubMed:26562023}.
Q6IQ20	reviewed	NAPEP_HUMAN	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54)	NAPEPLD C7orf18	Homo sapiens (Human)	393	FUNCTION: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:16527816, PubMed:27571266, PubMed:25684574). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity). {ECO:0000250|UniProtKB:Q8BH82, ECO:0000269|PubMed:14634025, ECO:0000269|PubMed:16527816, ECO:0000269|PubMed:25684574, ECO:0000269|PubMed:27571266}.		host-mediated regulation of intestinal microbiota composition [GO:0048874]; N-acylethanolamine metabolic process [GO:0070291]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phospholipid catabolic process [GO:0009395]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of inflammatory response [GO:0050729]; retinoid metabolic process [GO:0001523]; temperature homeostasis [GO:0001659]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane-bounded organelle [GO:0043227]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; photoreceptor outer segment membrane [GO:0042622]	bile acid binding [GO:0032052]; identical protein binding [GO:0042802]; N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity [GO:0102200]; N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane-bounded organelle [GO:0043227]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; photoreceptor outer segment membrane [GO:0042622]; bile acid binding [GO:0032052]; identical protein binding [GO:0042802]; N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity [GO:0102200]; N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; zinc ion binding [GO:0008270]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; N-acylethanolamine metabolic process [GO:0070291]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phospholipid catabolic process [GO:0009395]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of inflammatory response [GO:0050729]; retinoid metabolic process [GO:0001523]; temperature homeostasis [GO:0001659]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:25684574}; Peripheral membrane protein {ECO:0000305|PubMed:25684574}. Early endosome membrane {ECO:0000269|PubMed:25684574}; Peripheral membrane protein {ECO:0000305|PubMed:25684574}. Nucleus envelope {ECO:0000269|PubMed:25684574}. Nucleus, nucleoplasm {ECO:0000269|PubMed:25684574}. Note=Localized in the proximity of the cellular membranes likely through interaction with membrane phospholipids. {ECO:0000269|PubMed:25684574}.
Q6IQ22	reviewed	RAB12_HUMAN	Ras-related protein Rab-12	RAB12	Homo sapiens (Human)	244	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). {ECO:0000250}.		autophagy [GO:0006914]; endocytic recycling [GO:0032456]; endosome to lysosome transport [GO:0008333]; Golgi vesicle fusion to target membrane [GO:0048210]; protein catabolic process [GO:0030163]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network transport vesicle [GO:0030140]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network transport vesicle [GO:0030140]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagy [GO:0006914]; endocytic recycling [GO:0032456]; endosome to lysosome transport [GO:0008333]; Golgi vesicle fusion to target membrane [GO:0048210]; protein catabolic process [GO:0030163]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:P35283}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000250|UniProtKB:P35283}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P51152}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:P35283}.
Q6IQ23	reviewed	PKHA7_HUMAN	Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)	PLEKHA7	Homo sapiens (Human)	1121	FUNCTION: Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}.		cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell-cell adhesion [GO:0090136]; pore complex assembly [GO:0046931]; zonula adherens maintenance [GO:0045218]	cell junction [GO:0030054]; centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; pore complex [GO:0046930]; zonula adherens [GO:0005915]	delta-catenin binding [GO:0070097]	cell junction [GO:0030054]; centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; pore complex [GO:0046930]; zonula adherens [GO:0005915]; delta-catenin binding [GO:0070097]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell-cell adhesion [GO:0090136]; pore complex assembly [GO:0046931]; zonula adherens maintenance [GO:0045218]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. Cytoplasm {ECO:0000269|PubMed:19041755}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19041755}. Note=Localizes to zonula adherens, recruited via its interaction with CTNND1. {ECO:0000269|PubMed:19041755}.
Q6IQ26	reviewed	DEN5A_HUMAN	DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1)	DENND5A KIAA1091 RAB6IP1	Homo sapiens (Human)	1287	FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}.		negative regulation of neuron projection development [GO:0010977]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; negative regulation of neuron projection development [GO:0010977]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6PAL8}.
Q6IQ49	reviewed	SDE2_HUMAN	Splicing regulator SDE2 (Replication stress response regulator SDE2)	SDE2 C1orf55	Homo sapiens (Human)	451	FUNCTION: Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (PubMed:27906959). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (PubMed:27906959). {ECO:0000269|PubMed:27906959}.; FUNCTION: Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (PubMed:34365507). May recruit CACTIN to the spliceosome (By similarity). {ECO:0000250|UniProtKB:O14113, ECO:0000269|PubMed:34365507}.; FUNCTION: Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (PubMed:34365507). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (PubMed:34365507). {ECO:0000269|PubMed:34365507}.		cell division [GO:0051301]; cellular response to UV [GO:0034644]; DNA replication [GO:0006260]; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA cis splicing, via spliceosome [GO:0045292]; protein processing [GO:0016485]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	damaged DNA binding [GO:0003684]; snoRNA binding [GO:0030515]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; damaged DNA binding [GO:0003684]; snoRNA binding [GO:0030515]; cell division [GO:0051301]; cellular response to UV [GO:0034644]; DNA replication [GO:0006260]; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA cis splicing, via spliceosome [GO:0045292]; protein processing [GO:0016485]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27906959, ECO:0000269|PubMed:34365507}. Cytoplasm {ECO:0000269|PubMed:34365507}.
Q6IQ55	reviewed	TTBK2_HUMAN	Tau-tubulin kinase 2 (EC 2.7.11.1)	TTBK2 KIAA0847	Homo sapiens (Human)	1244	FUNCTION: Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). {ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}.		cerebellar granular layer development [GO:0021681]; cerebellar granule cell precursor tangential migration [GO:0021935]; cerebellum development [GO:0021549]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule binding [GO:1904527]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of protein localization to microtubule [GO:1902817]; peptidyl-serine phosphorylation [GO:0018105]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]; smoothened signaling pathway [GO:0007224]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]	ATP binding [GO:0005524]; kinesin binding [GO:0019894]; microtubule plus-end binding [GO:0051010]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; ATP binding [GO:0005524]; kinesin binding [GO:0019894]; microtubule plus-end binding [GO:0051010]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; cerebellar granular layer development [GO:0021681]; cerebellar granule cell precursor tangential migration [GO:0021935]; cerebellum development [GO:0021549]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule binding [GO:1904527]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of protein localization to microtubule [GO:1902817]; peptidyl-serine phosphorylation [GO:0018105]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Note=Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus. {ECO:0000250}.
Q6IS24	reviewed	GLT17_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 17 (EC 2.4.1.41) (Polypeptide GalNAc transferase-like protein 3) (GalNAc-T-like protein 3) (pp-GaNTase-like protein 3) (Protein-UDP acetylgalactosaminyltransferase-like protein 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3) (Williams-Beuren syndrome chromosomal region 17 protein)	GALNT17 WBSCR17	Homo sapiens (Human)	598	FUNCTION: May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. {ECO:0000250|UniProtKB:Q9HCQ5}.		protein O-linked glycosylation [GO:0006493]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q6ISB3	reviewed	GRHL2_HUMAN	Grainyhead-like protein 2 homolog (Brother of mammalian grainyhead) (Transcription factor CP2-like 3)	GRHL2 BOM TFCP2L3	Homo sapiens (Human)	625	FUNCTION: Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:29309642, PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293). {ECO:0000250|UniProtKB:Q8K5C0, ECO:0000269|PubMed:19015635, ECO:0000269|PubMed:20938050, ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:23254293, ECO:0000269|PubMed:25152456, ECO:0000269|PubMed:29309642, ECO:0000305|PubMed:12175488}.	MISCELLANEOUS: GRHL genes (GRHL1, GRHL2 and GRHL3) show a paradoxal lack of redundancy despite their extensive sequence identity in the DNA-binding and protein dimerization domains and the fact that the core consensus DNA binding sites are identical. They have related but remarkably different functions during embryogenesis because of their differential spatiotemporal expression patterns during development. {ECO:0000250|UniProtKB:Q8K5C0}.	anterior neural tube closure [GO:0061713]; bicellular tight junction assembly [GO:0070830]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; cardiac ventricle morphogenesis [GO:0003208]; cell adhesion [GO:0007155]; cell junction assembly [GO:0034329]; cell population proliferation [GO:0008283]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; epidermis development [GO:0008544]; epithelial cell morphogenesis [GO:0003382]; epithelial cell morphogenesis involved in placental branching [GO:0060672]; epithelium migration [GO:0090132]; face development [GO:0060324]; lung epithelial cell differentiation [GO:0060487]; lung lobe morphogenesis [GO:0060463]; multicellular organism growth [GO:0035264]; negative regulation of keratinocyte differentiation [GO:0045617]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA methylation [GO:0044030]; regulation of transcription by RNA polymerase II [GO:0006357]	cell-cell junction [GO:0005911]; chromatin [GO:0000785]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	cell-cell junction [GO:0005911]; chromatin [GO:0000785]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; anterior neural tube closure [GO:0061713]; bicellular tight junction assembly [GO:0070830]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; cardiac ventricle morphogenesis [GO:0003208]; cell adhesion [GO:0007155]; cell junction assembly [GO:0034329]; cell population proliferation [GO:0008283]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; epidermis development [GO:0008544]; epithelial cell morphogenesis [GO:0003382]; epithelial cell morphogenesis involved in placental branching [GO:0060672]; epithelium migration [GO:0090132]; face development [GO:0060324]; lung epithelial cell differentiation [GO:0060487]; lung lobe morphogenesis [GO:0060463]; multicellular organism growth [GO:0035264]; negative regulation of keratinocyte differentiation [GO:0045617]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA methylation [GO:0044030]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20938050, ECO:0000269|PubMed:25152456, ECO:0000269|PubMed:29499165}. Membrane {ECO:0000269|PubMed:25152456}. Note=detected at cell-cell contact areas. {ECO:0000269|PubMed:25152456}.
Q6ISU1	reviewed	PTCRA_HUMAN	Pre T-cell antigen receptor alpha (pT-alpha) (pTa) (pT-alpha-TCR)	PTCRA	Homo sapiens (Human)	281	FUNCTION: The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. {ECO:0000250}.		negative regulation of thymocyte apoptotic process [GO:0070244]	membrane [GO:0016020]		membrane [GO:0016020]; negative regulation of thymocyte apoptotic process [GO:0070244]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6IWH7	reviewed	ANO7_HUMAN	Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G)	ANO7 NGEP PCANAP5 TMEM16G	Homo sapiens (Human)	933	FUNCTION: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22075693). May play a role in cell-cell interactions (PubMed:17308099). {ECO:0000250|UniProtKB:Q14AT5, ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:22075693}.	MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.	calcium activated phospholipid scrambling [GO:0061588]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]	anchoring junction [GO:0070161]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983]	anchoring junction [GO:0070161]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983]; calcium activated phospholipid scrambling [GO:0061588]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:14981236, ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:17308099}. Endoplasmic reticulum {ECO:0000269|PubMed:22075693}. Note=Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604. {ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22075693}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:14981236}.
Q6J4K2	reviewed	NCLX_HUMAN	Mitochondrial sodium/calcium exchanger protein (Na(+)/K(+)/Ca(2+)-exchange protein 6) (Sodium/calcium exchanger protein, mitochondrial) (Sodium/potassium/calcium exchanger 6) (Solute carrier family 24 member 6) (Solute carrier family 8 member B1)	SLC8B1 NCKX6 NCLX SLC24A6	Homo sapiens (Human)	584	FUNCTION: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:15060069, PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928, PubMed:28130126). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (PubMed:15060069, PubMed:28130126). In contrast to other members of the family its function is independent of K(+) (PubMed:15060069). {ECO:0000250|UniProtKB:Q925Q3, ECO:0000269|PubMed:15060069, ECO:0000269|PubMed:20018762, ECO:0000269|PubMed:22829870, ECO:0000269|PubMed:23056385, ECO:0000269|PubMed:24898248, ECO:0000269|PubMed:28219928}.		calcium export from the mitochondrion [GO:0099093]; glucose homeostasis [GO:0042593]; intracellular calcium ion homeostasis [GO:0006874]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; monoatomic ion transport [GO:0006811]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of insulin secretion [GO:0050796]; regulation of lymphocyte chemotaxis [GO:1901623]; regulation of store-operated calcium entry [GO:2001256]; response to stimulus [GO:0050896]	membrane [GO:0016020]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	calcium:monoatomic cation antiporter activity [GO:0015368]; calcium:sodium antiporter activity [GO:0005432]; calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential [GO:0086038]; protein homodimerization activity [GO:0042803]	membrane [GO:0016020]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; calcium:monoatomic cation antiporter activity [GO:0015368]; calcium:sodium antiporter activity [GO:0005432]; calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential [GO:0086038]; protein homodimerization activity [GO:0042803]; calcium export from the mitochondrion [GO:0099093]; glucose homeostasis [GO:0042593]; intracellular calcium ion homeostasis [GO:0006874]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; monoatomic ion transport [GO:0006811]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of insulin secretion [GO:0050796]; regulation of lymphocyte chemotaxis [GO:1901623]; regulation of store-operated calcium entry [GO:2001256]; response to stimulus [GO:0050896]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:20018762, ECO:0000269|PubMed:23056385}; Multi-pass membrane protein {ECO:0000269|PubMed:20018762, ECO:0000269|PubMed:23056385}.
Q6J9G0	reviewed	STYK1_HUMAN	Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)	STYK1 NOK	Homo sapiens (Human)	422	FUNCTION: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). {ECO:0000250}.		phosphorylation [GO:0016310]; regulation of apoptotic process [GO:0042981]	plasma membrane [GO:0005886]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]	plasma membrane [GO:0005886]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; phosphorylation [GO:0016310]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6JBY9	reviewed	CPZIP_HUMAN	CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1)	RCSD1 CAPZIP	Homo sapiens (Human)	416	FUNCTION: Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}.		cellular hyperosmotic response [GO:0071474]; protein localization to endosome [GO:0036010]; retrograde transport, endosome to Golgi [GO:0042147]; skeletal muscle contraction [GO:0003009]	actin filament [GO:0005884]; cytosol [GO:0005829]; early endosome [GO:0005769]; WASH complex [GO:0071203]	actin filament binding [GO:0051015]; phosphatidylinositol phosphate binding [GO:1901981]; retromer complex binding [GO:1905394]	actin filament [GO:0005884]; cytosol [GO:0005829]; early endosome [GO:0005769]; WASH complex [GO:0071203]; actin filament binding [GO:0051015]; phosphatidylinositol phosphate binding [GO:1901981]; retromer complex binding [GO:1905394]; cellular hyperosmotic response [GO:0071474]; protein localization to endosome [GO:0036010]; retrograde transport, endosome to Golgi [GO:0042147]; skeletal muscle contraction [GO:0003009]	
Q6JQN1	reviewed	ACD10_HUMAN	Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-)	ACAD10	Homo sapiens (Human)	1059	FUNCTION: Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA. {ECO:0000269|PubMed:21237683}.		fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]	
Q6K0P9	reviewed	IFIX_HUMAN	Pyrin and HIN domain-containing protein 1 (Interferon-inducible protein X)	PYHIN1 IFIX	Homo sapiens (Human)	492	FUNCTION: Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. {ECO:0000269|PubMed:16479015, ECO:0000269|PubMed:18247378}.		activation of innate immune response [GO:0002218]; cell cycle [GO:0007049]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-beta [GO:0035458]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	double-stranded DNA binding [GO:0003690]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; double-stranded DNA binding [GO:0003690]; ubiquitin protein ligase binding [GO:0031625]; activation of innate immune response [GO:0002218]; cell cycle [GO:0007049]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-beta [GO:0035458]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleoplasm.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus. Nucleus speckle.
Q6KB66	reviewed	K2C80_HUMAN	Keratin, type II cytoskeletal 80 (Cytokeratin-80) (CK-80) (Keratin-80) (K80) (Type-II keratin Kb20)	KRT80 KB20	Homo sapiens (Human)	452		MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
Q6KC79	reviewed	NIPBL_HUMAN	Nipped-B-like protein (Delangin) (SCC2 homolog)	NIPBL IDN3 SCC2	Homo sapiens (Human)	2804	FUNCTION: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.		brain development [GO:0007420]; cellular response to X-ray [GO:0071481]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; developmental growth [GO:0048589]; digestive tract development [GO:0048565]; DNA damage response [GO:0006974]; ear morphogenesis [GO:0042471]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic forelimb morphogenesis [GO:0035115]; embryonic viscerocranium morphogenesis [GO:0048703]; establishment of mitotic sister chromatid cohesion [GO:0034087]; establishment of protein localization to chromatin [GO:0071169]; external genitalia morphogenesis [GO:0035261]; eye morphogenesis [GO:0048592]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; forelimb morphogenesis [GO:0035136]; gallbladder development [GO:0061010]; heart morphogenesis [GO:0003007]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; metanephros development [GO:0001656]; mitotic cohesin loading [GO:0061780]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuron migration [GO:2001224]; positive regulation of ossification [GO:0045778]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of developmental growth [GO:0048638]; regulation of embryonic development [GO:0045995]; regulation of hair cycle [GO:0042634]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; sensory perception of sound [GO:0007605]; somatic stem cell population maintenance [GO:0035019]; uterus morphogenesis [GO:0061038]	chromatin [GO:0000785]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; integrator complex [GO:0032039]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Scc2-Scc4 cohesin loading complex [GO:0090694]; SMC loading complex [GO:0032116]	chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; cohesin loader activity [GO:0061775]; histone deacetylase binding [GO:0042826]; mediator complex binding [GO:0036033]; promoter-specific chromatin binding [GO:1990841]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; integrator complex [GO:0032039]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Scc2-Scc4 cohesin loading complex [GO:0090694]; SMC loading complex [GO:0032116]; chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; cohesin loader activity [GO:0061775]; histone deacetylase binding [GO:0042826]; mediator complex binding [GO:0036033]; promoter-specific chromatin binding [GO:1990841]; transcription corepressor activity [GO:0003714]; brain development [GO:0007420]; cellular response to X-ray [GO:0071481]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; developmental growth [GO:0048589]; digestive tract development [GO:0048565]; DNA damage response [GO:0006974]; ear morphogenesis [GO:0042471]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic forelimb morphogenesis [GO:0035115]; embryonic viscerocranium morphogenesis [GO:0048703]; establishment of mitotic sister chromatid cohesion [GO:0034087]; establishment of protein localization to chromatin [GO:0071169]; external genitalia morphogenesis [GO:0035261]; eye morphogenesis [GO:0048592]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; forelimb morphogenesis [GO:0035136]; gallbladder development [GO:0061010]; heart morphogenesis [GO:0003007]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; metanephros development [GO:0001656]; mitotic cohesin loading [GO:0061780]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuron migration [GO:2001224]; positive regulation of ossification [GO:0045778]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of developmental growth [GO:0048638]; regulation of embryonic development [GO:0045995]; regulation of hair cycle [GO:0042634]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; sensory perception of sound [GO:0007605]; somatic stem cell population maintenance [GO:0035019]; uterus morphogenesis [GO:0061038]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. Chromosome {ECO:0000250|UniProtKB:Q6KCD5}.
Q6KCM7	reviewed	SCMC2_HUMAN	Mitochondrial adenyl nucleotide antiporter SLC25A25 (Mitochondrial ATP-Mg/Pi carrier protein 3) (Mitochondrial Ca(2+)-dependent solute carrier protein 3) (Short calcium-binding mitochondrial carrier protein 2) (SCaMC-2) (Solute carrier family 25 member 25)	SLC25A25 APC3 KIAA1896 MCSC3 SCAMC2 UNQ549/PRO1106	Homo sapiens (Human)	469	FUNCTION: Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it could have a broader specificity for adenyl nucleotides. By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways. {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:34346195}.		adipose tissue development [GO:0060612]; ADP transport [GO:0015866]; ATP metabolic process [GO:0046034]; ATP transport [GO:0015867]; calcium ion transmembrane transport [GO:0070588]; camera-type eye development [GO:0043010]; cellular respiration [GO:0045333]; multicellular organism growth [GO:0035264]; response to activity [GO:0014823]; response to dietary excess [GO:0002021]; response to food [GO:0032094]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	ATP transmembrane transporter activity [GO:0005347]; ATP:inorganic phosphate antiporter activity [GO:0140987]; calcium ion binding [GO:0005509]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ATP transmembrane transporter activity [GO:0005347]; ATP:inorganic phosphate antiporter activity [GO:0140987]; calcium ion binding [GO:0005509]; adipose tissue development [GO:0060612]; ADP transport [GO:0015866]; ATP metabolic process [GO:0046034]; ATP transport [GO:0015867]; calcium ion transmembrane transport [GO:0070588]; camera-type eye development [GO:0043010]; cellular respiration [GO:0045333]; multicellular organism growth [GO:0035264]; response to activity [GO:0014823]; response to dietary excess [GO:0002021]; response to food [GO:0032094]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:15054102, ECO:0000305|PubMed:15123600}; Multi-pass membrane protein {ECO:0000255}.
Q6KF10	reviewed	GDF6_HUMAN	Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16)	GDF6 BMP13 GDF16	Homo sapiens (Human)	455	FUNCTION: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity). {ECO:0000250|UniProtKB:P43028, ECO:0000269|PubMed:23307924, ECO:0000269|PubMed:26643732}.		activin receptor signaling pathway [GO:0032924]; apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; cell migration involved in metanephros development [GO:0035788]; fat cell differentiation [GO:0045444]; metanephros development [GO:0001656]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of SMAD protein signal transduction [GO:0060391]; retinal cell apoptotic process [GO:1990009]; SMAD protein signal transduction [GO:0060395]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; activin receptor signaling pathway [GO:0032924]; apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; cell migration involved in metanephros development [GO:0035788]; fat cell differentiation [GO:0045444]; metanephros development [GO:0001656]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of SMAD protein signal transduction [GO:0060391]; retinal cell apoptotic process [GO:1990009]; SMAD protein signal transduction [GO:0060395]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23307924}.
Q6L8G4	reviewed	KR511_HUMAN	Keratin-associated protein 5-11 (Keratin-associated protein 5.11) (Ultrahigh sulfur keratin-associated protein 5.11)	KRTAP5-11 KAP5.11 KRTAP5.11	Homo sapiens (Human)	156	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q6L8G8	reviewed	KRA57_HUMAN	Keratin-associated protein 5-7 (Keratin-associated protein 5-3) (Keratin-associated protein 5.3) (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7)	KRTAP5-7 KAP5-7 KAP5.3 KRTAP5.3 KRTAP5.7	Homo sapiens (Human)	165	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q6L8G9	reviewed	KRA56_HUMAN	Keratin-associated protein 5-6 (Keratin-associated protein 5.6) (Ultrahigh sulfur keratin-associated protein 5.6)	KRTAP5-6 KAP5.6 KRTAP5.6	Homo sapiens (Human)	129	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q6L8H1	reviewed	KRA54_HUMAN	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4)	KRTAP5-4 KAP5.4 KRTAP5.4	Homo sapiens (Human)	288	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q6L8H2	reviewed	KRA53_HUMAN	Keratin-associated protein 5-3 (Keratin-associated protein 5-9) (Keratin-associated protein 5.3) (Keratin-associated protein 5.9) (UHS KerB-like) (Ultrahigh sulfur keratin-associated protein 5.3)	KRTAP5-3 KAP5-9 KAP5.3 KRTAP5-9 KRTAP5.3 KRTAP5.9	Homo sapiens (Human)	238	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q6L8H4	reviewed	KRA51_HUMAN	Keratin-associated protein 5-1 (Keratin, cuticle, ultrahigh sulphur 1-like) (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1)	KRTAP5-1 KAP5.1 KRN1L KRTAP5.1	Homo sapiens (Human)	278	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q6L8Q7	reviewed	PDE12_HUMAN	2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4)	PDE12	Homo sapiens (Human)	609	FUNCTION: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:30389976, PubMed:26055709). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}.		antiviral innate immune response [GO:0140374]; cellular response to dsRNA [GO:0071359]; cellular response to interferon-alpha [GO:0035457]; cellular response to type II interferon [GO:0071346]; defense response to virus [GO:0051607]; mitochondrial mRNA catabolic process [GO:0000958]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of viral genome replication [GO:0045070]; regulation of mitochondrial mRNA stability [GO:0044528]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	3'-5'-RNA exonuclease activity [GO:0000175]; exonuclease activity [GO:0004527]; metal ion binding [GO:0046872]; oligoribonucleotidase activity [GO:0034611]; poly(A)-specific ribonuclease activity [GO:0004535]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 3'-5'-RNA exonuclease activity [GO:0000175]; exonuclease activity [GO:0004527]; metal ion binding [GO:0046872]; oligoribonucleotidase activity [GO:0034611]; poly(A)-specific ribonuclease activity [GO:0004535]; antiviral innate immune response [GO:0140374]; cellular response to dsRNA [GO:0071359]; cellular response to interferon-alpha [GO:0035457]; cellular response to type II interferon [GO:0071346]; defense response to virus [GO:0051607]; mitochondrial mRNA catabolic process [GO:0000958]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of viral genome replication [GO:0045070]; regulation of mitochondrial mRNA stability [GO:0044528]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.
Q6L9W6	reviewed	B4GN3_HUMAN	Beta-1,4-N-acetylgalactosaminyltransferase 3 (B4GalNAcT3) (Beta4GalNAc-T3) (Beta4GalNAcT3) (EC 2.4.1.244) (Beta-1,4-N-acetylgalactosaminyltransferase III) (N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2) (NGalNAc-T2)	B4GALNT3	Homo sapiens (Human)	998	FUNCTION: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa. {ECO:0000269|PubMed:16728562}.			Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231]	acetylgalactosaminyltransferase activity [GO:0008376]; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231]; acetylgalactosaminyltransferase activity [GO:0008376]; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:16728562}; Single-pass type II membrane protein {ECO:0000269|PubMed:16728562}. Note=Localizes to apical Golgi.
Q6MZM0	reviewed	HPHL1_HUMAN	Ferroxidase HEPHL1 (EC 1.16.3.1) (Hephaestin-like protein 1)	HEPHL1	Homo sapiens (Human)	1159	FUNCTION: Is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe(2+) to Fe(3+) without releasing radical oxygen species (PubMed:31125343). May be involved in the regulation of intracellular iron content (PubMed:31125343). {ECO:0000269|PubMed:31125343}.		copper ion transport [GO:0006825]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]	plasma membrane [GO:0005886]	copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322]	plasma membrane [GO:0005886]; copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322]; copper ion transport [GO:0006825]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6MZP7	reviewed	LIN54_HUMAN	Protein lin-54 homolog (CXC domain-containing protein 1)	LIN54 CXCDC1 KIAA2037	Homo sapiens (Human)	749	FUNCTION: Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17671431, PubMed:17531812). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258). {ECO:0000269|PubMed:17531812, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:19725879, ECO:0000269|PubMed:27465258}.		cell cycle [GO:0007049]; nucleosome organization [GO:0034728]; regulation of DNA-templated transcription [GO:0006355]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571]	metal ion binding [GO:0046872]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; transcription regulatory region nucleic acid binding [GO:0001067]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571]; metal ion binding [GO:0046872]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; transcription regulatory region nucleic acid binding [GO:0001067]; cell cycle [GO:0007049]; nucleosome organization [GO:0034728]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6MZQ0	reviewed	PRR5L_HUMAN	Proline-rich protein 5-like (Protein observed with Rictor-2) (Protor-2)	PRR5L PROTOR2	Homo sapiens (Human)	368	FUNCTION: Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062). {ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:21964062, ECO:0000269|PubMed:22609986}.		cellular response to oxidative stress [GO:0034599]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of signal transduction [GO:0009968]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of protein phosphorylation [GO:0001934]; regulation of fibroblast migration [GO:0010762]; TORC2 signaling [GO:0038203]	TORC2 complex [GO:0031932]	ubiquitin protein ligase binding [GO:0031625]	TORC2 complex [GO:0031932]; ubiquitin protein ligase binding [GO:0031625]; cellular response to oxidative stress [GO:0034599]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of signal transduction [GO:0009968]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of protein phosphorylation [GO:0001934]; regulation of fibroblast migration [GO:0010762]; TORC2 signaling [GO:0038203]	
Q6N021	reviewed	TET2_HUMAN	Methylcytosine dioxygenase TET2 (EC 1.14.11.80)	TET2 KIAA1546 Nbla00191	Homo sapiens (Human)	2002	FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485, ECO:0000269|PubMed:32518946}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	5-methylcytosine catabolic process [GO:0006211]; cell cycle [GO:0007049]; chromatin organization [GO:0006325]; DNA demethylation [GO:0080111]; leukocyte differentiation [GO:0002521]; myeloid cell differentiation [GO:0030099]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]; response to organic cyclic compound [GO:0014070]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; ferrous iron binding [GO:0008198]; methylcytosine dioxygenase activity [GO:0070579]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; ferrous iron binding [GO:0008198]; methylcytosine dioxygenase activity [GO:0070579]; zinc ion binding [GO:0008270]; 5-methylcytosine catabolic process [GO:0006211]; cell cycle [GO:0007049]; chromatin organization [GO:0006325]; DNA demethylation [GO:0080111]; leukocyte differentiation [GO:0002521]; myeloid cell differentiation [GO:0030099]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]; response to organic cyclic compound [GO:0014070]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25557551}. Chromosome {ECO:0000269|PubMed:25557551}. Note=Localization to chromatin depends upon monoubiquitination at Lys-1299. {ECO:0000269|PubMed:25557551}.
Q6N022	reviewed	TEN4_HUMAN	Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4)	TENM4 KIAA1302 ODZ4 TNM4	Homo sapiens (Human)	2769	FUNCTION: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}.		cardiac cell fate specification [GO:0060912]; cardiac muscle cell proliferation [GO:0060038]; central nervous system myelin formation [GO:0032289]; gastrulation with mouth forming second [GO:0001702]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; neuron development [GO:0048666]; positive regulation of gastrulation [GO:2000543]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of myelination [GO:0031641]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; cardiac cell fate specification [GO:0060912]; cardiac muscle cell proliferation [GO:0060038]; central nervous system myelin formation [GO:0032289]; gastrulation with mouth forming second [GO:0001702]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; neuron development [GO:0048666]; positive regulation of gastrulation [GO:2000543]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of myelination [GO:0031641]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26188006}; Single-pass membrane protein {ECO:0000255}. Cell projection {ECO:0000250|UniProtKB:Q3UHK6}. Nucleus {ECO:0000250|UniProtKB:Q3UHK6}. Cytoplasm {ECO:0000250|UniProtKB:Q3UHK6}.
Q6N043	reviewed	Z280D_HUMAN	Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634)	ZNF280D KIAA1584 SUHW4 ZNF634	Homo sapiens (Human)	979	FUNCTION: May function as a transcription factor.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6N069	reviewed	NAA16_HUMAN	N-alpha-acetyltransferase 16, NatA auxiliary subunit (NMDA receptor-regulated 1-like protein) (NARG1-like protein)	NAA16 NARG1L NAT2	Homo sapiens (Human)	864	FUNCTION: Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.		N-terminal protein amino acid acetylation [GO:0006474]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA-templated transcription [GO:0045893]; protein stabilization [GO:0050821]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; NatA complex [GO:0031415]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	ribosome binding [GO:0043022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; NatA complex [GO:0031415]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ribosome binding [GO:0043022]; N-terminal protein amino acid acetylation [GO:0006474]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA-templated transcription [GO:0045893]; protein stabilization [GO:0050821]	
Q6N075	reviewed	MFSD5_HUMAN	Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) (hsMOT2)	MFSD5 UNQ832/PRO1759	Homo sapiens (Human)	450	FUNCTION: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. {ECO:0000269|PubMed:21464289}.		monoatomic ion transport [GO:0006811]	membrane [GO:0016020]; plasma membrane [GO:0005886]	molybdate ion transmembrane transporter activity [GO:0015098]	membrane [GO:0016020]; plasma membrane [GO:0005886]; molybdate ion transmembrane transporter activity [GO:0015098]; monoatomic ion transport [GO:0006811]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6NS38	reviewed	ALKB2_HUMAN	DNA oxidative demethylase ALKBH2 (EC 1.14.11.33) (Alkylated DNA repair protein alkB homolog 2) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2) (Oxy DC1)	ALKBH2 ABH2	Homo sapiens (Human)	261	FUNCTION: Dioxygenase that repairs alkylated nucleic acid bases by direct reversal oxidative dealkylation. Can process both double-stranded (ds) and single-stranded (ss) DNA substrates, with a strong preference for dsDNA (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:20714506, PubMed:25797601, PubMed:23972994). Uses molecular oxygen, 2-oxoglutarate and iron as cofactors to oxidize the alkyl groups that are subsequently released as aldehydes, regenerating the undamaged bases. Probes the base pair stability, locates a weakened base pair and flips the damaged base to accommodate the lesion in its active site for efficient catalysis (PubMed:18432238, PubMed:22659876). Repairs monoalkylated bases, specifically N1-methyladenine and N3-methylcytosine, as well as higher order alkyl adducts such as bases modified with exocyclic bridged adducts known as etheno adducts including 1,N6-ethenoadenine, 3,N4-ethenocytosine and 1,N2-ethenoguanine (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:20714506, PubMed:25797601, PubMed:23972994, PubMed:26408825). Acts as a gatekeeper of genomic integrity under alkylation stress. Efficiently repairs alkylated lesions in ribosomal DNA (rDNA). These lesions can cause ss- and dsDNA strand breaks that severely impair rDNA transcription (PubMed:23972994). In a response mechanism to DNA damage, associates with PCNA at replication forks to repair alkylated adducts prior to replication (PubMed:19736315, PubMed:26408825). {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:16174769, ECO:0000269|PubMed:18432238, ECO:0000269|PubMed:19736315, ECO:0000269|PubMed:20714506, ECO:0000269|PubMed:22659876, ECO:0000269|PubMed:23972994, ECO:0000269|PubMed:25797601, ECO:0000269|PubMed:26408825}.		DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; oxidative demethylation [GO:0070989]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cytosine C-5 DNA demethylase activity [GO:0051747]; DNA-N1-methyladenine dioxygenase activity [GO:0043734]; ferrous iron binding [GO:0008198]; oxidative DNA demethylase activity [GO:0035516]; rDNA binding [GO:0000182]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cytosine C-5 DNA demethylase activity [GO:0051747]; DNA-N1-methyladenine dioxygenase activity [GO:0043734]; ferrous iron binding [GO:0008198]; oxidative DNA demethylase activity [GO:0035516]; rDNA binding [GO:0000182]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; oxidative demethylation [GO:0070989]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:19736315}. Nucleus, nucleolus {ECO:0000269|PubMed:23972994}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23972994}. Note=Relocates to the replication foci during S-phase. {ECO:0000269|PubMed:12594517}.
Q6NSI4	reviewed	RADX_HUMAN	RPA-related protein RADX (RPA-related and RAD51-antagonist, X-chromosome)	RADX CXorf57	Homo sapiens (Human)	855	FUNCTION: Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897). {ECO:0000269|PubMed:28735897}.		negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA repair [GO:0006282]	nuclear speck [GO:0016607]; replication fork [GO:0005657]	RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]	nuclear speck [GO:0016607]; replication fork [GO:0005657]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA repair [GO:0006282]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:28735897}. Note=Recruited to replication forks. {ECO:0000269|PubMed:28735897}.
Q6NSJ0	reviewed	MYORG_HUMAN	Myogenesis-regulating glycosidase (EC 3.2.1.-) (Uncharacterized family 31 glucosidase KIAA1161)	MYORG KIAA1161	Homo sapiens (Human)	714	FUNCTION: Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2. {ECO:0000250|UniProtKB:Q69ZQ1}.	MISCELLANEOUS: The requirement of the predicted catalytic residue Asp-463 to support myogenic function strongly suggests that MYORG is an enzymatically active glycosidase in vivo, even if concrete experimental proof for enzymatic activity is still missing. {ECO:0000305|PubMed:19706595}.	carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; skeletal muscle fiber development [GO:0048741]	endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]	hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; skeletal muscle fiber development [GO:0048741]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q69ZQ1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q69ZQ1}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:29910000}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q69ZQ1}. Note=Only a minor fraction is present in the peripheral endoplasmic reticulum. {ECO:0000250|UniProtKB:Q69ZQ1}.
Q6NSJ5	reviewed	LRC8E_HUMAN	Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E)	LRRC8E	Homo sapiens (Human)	796	FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:33139539). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:33139539, ECO:0000269|PubMed:33171122}.		aspartate transmembrane transport [GO:0015810]; cell volume homeostasis [GO:0006884]; cellular response to osmotic stress [GO:0071470]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; monoatomic anion transmembrane transport [GO:0098656]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]	volume-sensitive anion channel activity [GO:0005225]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]; volume-sensitive anion channel activity [GO:0005225]; aspartate transmembrane transport [GO:0015810]; cell volume homeostasis [GO:0006884]; cellular response to osmotic stress [GO:0071470]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; monoatomic anion transmembrane transport [GO:0098656]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:24790029}. Lysosome membrane {ECO:0000269|PubMed:33139539}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:33139539}; Multi-pass membrane protein {ECO:0000305}. Note=In the absence of LRRC8A, resides primarily in the endoplasmic reticulum (PubMed:24790029, PubMed:33139539). Requires LRRC8A for localization at the cell membrane or lysosome membrane (PubMed:24790029, PubMed:33139539). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:33139539}.
Q6NSW7	reviewed	NANP8_HUMAN	Homeobox protein NANOGP8	NANOGP8	Homo sapiens (Human)	305	FUNCTION: May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S phase and cell proliferation. {ECO:0000250, ECO:0000269|PubMed:16623708}.		positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell population proliferation [GO:0008284]; regulation of transcription by RNA polymerase II [GO:0006357]	intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell population proliferation [GO:0008284]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:16623708}.
Q6NT16	reviewed	S18B1_HUMAN	MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) (Vesicular polyamine transporter) (VPAT)	SLC18B1 C6orf192	Homo sapiens (Human)	456	FUNCTION: Proton-coupled polyamine antiporter involved in the translocation of polyamines from cytosol into secretory vesicles prior to their release via exocytosis. Uses the electrochemical proton gradient generated by a V-type proton-pumping ATPase to couple the efflux of protons with the uptake of a polyamine molecule (PubMed:25355561). Facilitates vesicular storage of spermine and spermidine in astrocytes with an impact on glutamatergic neuronal transmission and memory formation (PubMed:25355561) (By similarity). Upon antigen stimulation, regulates polyamine accumulation and release in mast cell secretory granules, which in turn potentiates mast cell degranulation and histamine secretion (By similarity). {ECO:0000250|UniProtKB:D3Z5L6, ECO:0000269|PubMed:25355561}.		serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; spermine transport [GO:0000296]	secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]	monoamine:proton antiporter activity [GO:0015311]; polyamine:proton antiporter activity [GO:0015312]; transmembrane transporter activity [GO:0022857]	secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]; monoamine:proton antiporter activity [GO:0015311]; polyamine:proton antiporter activity [GO:0015312]; transmembrane transporter activity [GO:0022857]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; spermine transport [GO:0000296]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:D3Z5L6}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:D4A9K4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D4A9K4}. Note=Colocalizes with VAMP3 and VAMP8 in mast cell secretory granules, which are distinct from histamine- and serotonin-containing granules (By similarity). Partly colocalizes with SYP in synaptic vesicles in hippocampal neurons. Colocalizes with SYP and VAMP2 in secretory vesicles of astrocytes (By similarity). {ECO:0000250|UniProtKB:D3Z5L6, ECO:0000250|UniProtKB:D4A9K4}.
Q6NT55	reviewed	CP4FN_HUMAN	Ultra-long-chain fatty acid omega-hydroxylase (EC 1.14.14.177) (Cytochrome P450 4F22)	CYP4F22	Homo sapiens (Human)	531	FUNCTION: A cytochrome P450 monooxygenase involved in epidermal ceramide biosynthesis. Hydroxylates the terminal carbon (omega-hydroxylation) of ultra-long-chain fatty acyls (C28-C36) prior to ceramide synthesis (PubMed:26056268). Contributes to the synthesis of three classes of omega-hydroxy-ultra-long chain fatty acylceramides having sphingosine, 6-hydroxysphingosine and phytosphingosine bases, all major lipid components that underlie the permeability barrier of the stratum corneum (PubMed:26056268). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:26056268). {ECO:0000269|PubMed:26056268}.		ceramide biosynthetic process [GO:0046513]; icosanoid metabolic process [GO:0006690]	endoplasmic reticulum membrane [GO:0005789]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	endoplasmic reticulum membrane [GO:0005789]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; ceramide biosynthetic process [GO:0046513]; icosanoid metabolic process [GO:0006690]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26056268}; Single-pass type I membrane protein {ECO:0000269|PubMed:26056268}. Microsome membrane {ECO:0000269|PubMed:26056268}; Single-pass type I membrane protein {ECO:0000269|PubMed:26056268}.
Q6NT76	reviewed	HMBX1_HUMAN	Homeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1)	HMBOX1 HOT1 TAH1	Homo sapiens (Human)	420	FUNCTION: Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958). {ECO:0000250|UniProtKB:Q8BJA3, ECO:0000269|PubMed:23685356, ECO:0000269|PubMed:23813958}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chromatin binding [GO:0035563]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of telomerase activity [GO:0051972]	Cajal body [GO:0015030]; centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	double-stranded telomeric DNA binding [GO:0003691]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; telomeric DNA binding [GO:0042162]	Cajal body [GO:0015030]; centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; double-stranded telomeric DNA binding [GO:0003691]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; telomeric DNA binding [GO:0042162]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chromatin binding [GO:0035563]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of telomerase activity [GO:0051972]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16825764, ECO:0000269|PubMed:19728927}. Cytoplasm {ECO:0000269|PubMed:16825764, ECO:0000269|PubMed:19728927}. Chromosome, telomere {ECO:0000269|PubMed:23685356, ECO:0000269|PubMed:23813958}. Nucleus, Cajal body {ECO:0000269|PubMed:23685356}. Nucleus, PML body {ECO:0000269|PubMed:23813958}. Note=Predominantly detected in cytoplasm (PubMed:16825764, PubMed:19728927). Localizes in a dynamic manner to actively processed telomeres (PubMed:23685356). Localizes to the periphery of Cajal bodies (PubMed:23685356). Associates with PML nuclear bodies in telomerase-negative cells (PubMed:23813958). {ECO:0000269|PubMed:16825764, ECO:0000269|PubMed:19728927, ECO:0000269|PubMed:23685356, ECO:0000269|PubMed:23813958}.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus {ECO:0000269|PubMed:19757162}. Cytoplasm {ECO:0000269|PubMed:19757162}.
Q6NTE8	reviewed	MRNIP_HUMAN	MRN complex-interacting protein (MRN-interacting protein)	MRNIP C5orf45	Homo sapiens (Human)	343	FUNCTION: Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein kinase activity [GO:0045860]; protein localization to chromatin [GO:0071168]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; response to ionizing radiation [GO:0010212]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein kinase activity [GO:0045860]; protein localization to chromatin [GO:0071168]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27568553}. Nucleus, nucleoplasm {ECO:0000269|PubMed:27568553}. Note=Recruited to sites of DNA damage (PubMed:27568553). Phosphorylation on Ser-115 induces its nuclear localization and promotes genome stability (PubMed:27568553). {ECO:0000269|PubMed:27568553}.
Q6NTF7	reviewed	ABC3H_HUMAN	DNA dC->dU-editing enzyme APOBEC-3H (EC 3.5.4.38) (APOBEC-related protein 10) (ARP-10) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H) (A3H)	APOBEC3H	Homo sapiens (Human)	200	FUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269|PubMed:16571802, ECO:0000269|PubMed:16920826, ECO:0000269|PubMed:18299330, ECO:0000269|PubMed:18779051, ECO:0000269|PubMed:18827027, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22457529, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:23097438}.	MISCELLANEOUS: APOBEC3H from old world monkeys has retained its antiviral activity, while it is lost in other primates.; MISCELLANEOUS: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.	clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; retrotransposon silencing [GO:0010526]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]	cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; retrotransposon silencing [GO:0010526]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.
Q6NTF9	reviewed	RHBD2_HUMAN	Rhomboid domain-containing protein 2	RHBDD2 RHBDL7	Homo sapiens (Human)	364			endoplasmic reticulum unfolded protein response [GO:0030968]; ubiquitin-dependent ERAD pathway [GO:0030433]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	misfolded protein binding [GO:0051787]; serine-type endopeptidase activity [GO:0004252]; ubiquitin-specific protease binding [GO:1990381]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; misfolded protein binding [GO:0051787]; serine-type endopeptidase activity [GO:0004252]; ubiquitin-specific protease binding [GO:1990381]; endoplasmic reticulum unfolded protein response [GO:0030968]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q6NUI2	reviewed	GPAT2_HUMAN	Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT-2) (EC 2.3.1.15) (1-acylglycerol-3-phosphate O-acyltransferase GPAT2) (EC 2.3.1.51) (xGPAT1)	GPAT2	Homo sapiens (Human)	795	FUNCTION: Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids. In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA). Prefers arachidonoyl-CoA as the acyl donor. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity. {ECO:0000250|UniProtKB:Q14DK4}.		CDP-diacylglycerol biosynthetic process [GO:0016024]; fatty acid metabolic process [GO:0006631]; glycerol-3-phosphate metabolic process [GO:0006072]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]; piRNA processing [GO:0034587]; triglyceride biosynthetic process [GO:0019432]	mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420]	mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420]; CDP-diacylglycerol biosynthetic process [GO:0016024]; fatty acid metabolic process [GO:0006631]; glycerol-3-phosphate metabolic process [GO:0006072]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]; piRNA processing [GO:0034587]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q14DK4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14DK4}.
Q6NUI6	reviewed	CHADL_HUMAN	Chondroadherin-like protein	CHADL SLRR4B	Homo sapiens (Human)	762	FUNCTION: Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment. {ECO:0000269|PubMed:25451920}.		negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of collagen fibril organization [GO:1904027]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	collagen binding [GO:0005518]; collagen fibril binding [GO:0098633]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; collagen binding [GO:0005518]; collagen fibril binding [GO:0098633]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of collagen fibril organization [GO:1904027]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25451920}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:E9Q7T7}.
Q6NUJ2	reviewed	CK087_HUMAN	Uncharacterized protein C11orf87	C11orf87	Homo sapiens (Human)	197				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6NUJ5	reviewed	PWP2B_HUMAN	PWWP domain-containing protein 2B	PWWP2B PWWP2	Homo sapiens (Human)	590	FUNCTION: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}.		chromatin remodeling [GO:0006338]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cold-induced thermogenesis [GO:0120161]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	NuRD complex binding [GO:0120325]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex binding [GO:0120325]; chromatin remodeling [GO:0006338]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cold-induced thermogenesis [GO:0120161]	
Q6NUK1	reviewed	SCMC1_HUMAN	Mitochondrial adenyl nucleotide antiporter SLC25A24 (Mitochondrial ATP-Mg/Pi carrier protein 1) (Mitochondrial Ca(2+)-dependent solute carrier protein 1) (Short calcium-binding mitochondrial carrier protein 1) (SCaMC-1) (Solute carrier family 25 member 24)	SLC25A24 APC1 MCSC1 SCAMC1	Homo sapiens (Human)	477	FUNCTION: Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways (PubMed:15123600, PubMed:22015608). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600). May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates (PubMed:22015608, PubMed:29100093). {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:22015608, ECO:0000269|PubMed:29100093}.		adenine nucleotide transport [GO:0051503]; ADP transport [GO:0015866]; ATP transport [GO:0015867]; cellular response to calcium ion [GO:0071277]; cellular response to oxidative stress [GO:0034599]; mitochondrial ATP transmembrane transport [GO:1990544]; mitochondrial transport [GO:0006839]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	adenine nucleotide transmembrane transporter activity [GO:0000295]; ADP:inorganic phosphate antiporter activity [GO:0140988]; ATP transmembrane transporter activity [GO:0005347]; ATP:inorganic phosphate antiporter activity [GO:0140987]; calcium ion binding [GO:0005509]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; adenine nucleotide transmembrane transporter activity [GO:0000295]; ADP:inorganic phosphate antiporter activity [GO:0140988]; ATP transmembrane transporter activity [GO:0005347]; ATP:inorganic phosphate antiporter activity [GO:0140987]; calcium ion binding [GO:0005509]; adenine nucleotide transport [GO:0051503]; ADP transport [GO:0015866]; ATP transport [GO:0015867]; cellular response to calcium ion [GO:0071277]; cellular response to oxidative stress [GO:0034599]; mitochondrial ATP transmembrane transport [GO:1990544]; mitochondrial transport [GO:0006839]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:15054102, ECO:0000305|PubMed:15123600, ECO:0000305|PubMed:22015608}; Multi-pass membrane protein {ECO:0000255}.
Q6NUN0	reviewed	ACSM5_HUMAN	Acyl-coenzyme A synthetase ACSM5, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 5)	ACSM5 MACS3	Homo sapiens (Human)	579	FUNCTION: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. {ECO:0000250|UniProtKB:Q08AH1}.		acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]	mitochondrial matrix [GO:0005759]	ATP binding [GO:0005524]; butyrate-CoA ligase activity [GO:0047760]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; GTP binding [GO:0005525]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; metal ion binding [GO:0046872]	mitochondrial matrix [GO:0005759]; ATP binding [GO:0005524]; butyrate-CoA ligase activity [GO:0047760]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; GTP binding [GO:0005525]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; metal ion binding [GO:0046872]; acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q91VA0}.
Q6NUN9	reviewed	ZN746_HUMAN	Zinc finger protein 746 (Parkin-interacting substrate) (PARIS)	ZNF746 PARIS	Homo sapiens (Human)	644	FUNCTION: Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. {ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:31856708}.	MISCELLANEOUS: May act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN: its accumulation due to the absence of PRKN, followed by up-regulation of PPARGC1A, could lead to the selective loss of dopamine neurons in the substantia nigra. {ECO:0000305|PubMed:21376232}.	negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21376232}. Nucleus {ECO:0000305|PubMed:21376232}. Note=Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.
Q6NUP7	reviewed	PP4R4_HUMAN	Serine/threonine-protein phosphatase 4 regulatory subunit 4	PPP4R4 KIAA1622 PP4R4	Homo sapiens (Human)	873	FUNCTION: Putative regulatory subunit of serine/threonine-protein phosphatase 4.		blastocyst hatching [GO:0001835]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; regulation of protein serine/threonine phosphatase activity [GO:0080163]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein serine/threonine phosphatase complex [GO:0008287]	protein phosphatase regulator activity [GO:0019888]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein serine/threonine phosphatase complex [GO:0008287]; protein phosphatase regulator activity [GO:0019888]; blastocyst hatching [GO:0001835]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; regulation of protein serine/threonine phosphatase activity [GO:0080163]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18715871}.
Q6NUQ1	reviewed	RINT1_HUMAN	RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1)	RINT1	Homo sapiens (Human)	792	FUNCTION: Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for telomere length control (PubMed:16600870). {ECO:0000269|PubMed:11096100, ECO:0000269|PubMed:16600870, ECO:0000305}.	MISCELLANEOUS: According to PubMed:11096100, a longer form, which may be due to the differential initiation of translation using a non-AUG codon, may exist. However, the existence of such form has not been clearly demonstrated.	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]		cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein.
Q6NUQ4	reviewed	TM214_HUMAN	Transmembrane protein 214	TMEM214 PP446	Homo sapiens (Human)	689	FUNCTION: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress. {ECO:0000269|PubMed:23661706}.		apoptotic process [GO:0006915]	cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]		cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; apoptotic process [GO:0006915]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23661706}; Multi-pass membrane protein {ECO:0000269|PubMed:23661706}.
Q6NUS6	reviewed	TECT3_HUMAN	Tectonic-3	TCTN3 C10orf61 TECT3 PSEC0041 UNQ1881/PRO4324	Homo sapiens (Human)	607	FUNCTION: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway. {ECO:0000250, ECO:0000269|PubMed:17464193, ECO:0000269|PubMed:22883145}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	apoptotic process [GO:0006915]; cilium assembly [GO:0060271]; positive regulation of apoptotic process [GO:0043065]; smoothened signaling pathway [GO:0007224]	ciliary membrane [GO:0060170]; nucleus [GO:0005634]		ciliary membrane [GO:0060170]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; cilium assembly [GO:0060271]; positive regulation of apoptotic process [GO:0043065]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6NUT2	reviewed	D19L2_HUMAN	Probable C-mannosyltransferase DPY19L2 (EC 2.4.1.-) (Dpy-19-like protein 2) (Protein dpy-19 homolog 2)	DPY19L2 UNQ3127/PRO10284	Homo sapiens (Human)	758	FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. {ECO:0000250|UniProtKB:P34413}.; FUNCTION: Required during spermatogenesis for sperm head elongation and acrosome formation (PubMed:21397063, PubMed:21397064). Also plays a role in acrosome attachment to the nuclear envelope (By similarity). {ECO:0000250|UniProtKB:P0CW70, ECO:0000269|PubMed:21397063, ECO:0000269|PubMed:21397064}.	MISCELLANEOUS: It has been suggested that DPY19L2P1 is an inactive pseudogene from which DPY19L2 has evolved by duplication. However, expressed transcript sequences derived from the DPY19L2P1 locus are known to exist.	spermatid development [GO:0007286]	nuclear inner membrane [GO:0005637]; nucleus [GO:0005634]	mannosyltransferase activity [GO:0000030]	nuclear inner membrane [GO:0005637]; nucleus [GO:0005634]; mannosyltransferase activity [GO:0000030]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:P0CW70}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with DPY19L2 at the inner nuclear membrane. {ECO:0000250|UniProtKB:P0CW70}.
Q6NUT3	reviewed	MFS12_HUMAN	Major facilitator superfamily domain-containing protein 12	MFSD12 C19orf28	Homo sapiens (Human)	480	FUNCTION: Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation (PubMed:33208952). In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation (PubMed:33208952). Also catalyzes import of cysteine into lysosomes in non-pigmented cells (PubMed:33208952). {ECO:0000269|PubMed:33208952}.		carbohydrate transport [GO:0008643]; cysteine transmembrane transport [GO:1903712]; melanin biosynthetic process [GO:0042438]; negative regulation of melanin biosynthetic process [GO:0048022]; organic substance transport [GO:0071702]; pigment metabolic process involved in pigmentation [GO:0043474]; regulation of melanin biosynthetic process [GO:0048021]	late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]	cysteine transmembrane transporter activity [GO:0033229]; symporter activity [GO:0015293]	late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; cysteine transmembrane transporter activity [GO:0033229]; symporter activity [GO:0015293]; carbohydrate transport [GO:0008643]; cysteine transmembrane transport [GO:1903712]; melanin biosynthetic process [GO:0042438]; negative regulation of melanin biosynthetic process [GO:0048022]; organic substance transport [GO:0071702]; pigment metabolic process involved in pigmentation [GO:0043474]; regulation of melanin biosynthetic process [GO:0048021]	SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:33208952}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:29025994, ECO:0000269|PubMed:33208952}; Multi-pass membrane protein {ECO:0000255}.
Q6NVH7	reviewed	SWAP1_HUMAN	ATPase SWSAP1 (SWIM-type zinc finger 7-associated protein 1) (SWS1-associated protein 1) (ZSWIM7-associated protein 1) (ZSWIM7AP1)	SWSAP1 C19orf39	Homo sapiens (Human)	229	FUNCTION: ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity. {ECO:0000269|PubMed:21965664}.		double-strand break repair via homologous recombination [GO:0000724]; protein stabilization [GO:0050821]	nucleus [GO:0005634]; Shu complex [GO:0097196]	ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	nucleus [GO:0005634]; Shu complex [GO:0097196]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]; double-strand break repair via homologous recombination [GO:0000724]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:21965664}.
Q6NVU6	reviewed	UFSP1_HUMAN	Inactive Ufm1-specific protease 1 (UfSP1)	UFSP1	Homo sapiens (Human)	142							
Q6NVY1	reviewed	HIBCH_HUMAN	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H)	HIBCH	Homo sapiens (Human)	386	FUNCTION: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000269|PubMed:8824301}.		branched-chain amino acid catabolic process [GO:0009083]; valine catabolic process [GO:0006574]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	3-hydroxyisobutyryl-CoA hydrolase activity [GO:0003860]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 3-hydroxyisobutyryl-CoA hydrolase activity [GO:0003860]; branched-chain amino acid catabolic process [GO:0009083]; valine catabolic process [GO:0006574]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
Q6NW40	reviewed	RGMB_HUMAN	Repulsive guidance molecule B (DRG11-responsive axonal guidance and outgrowth of neurite) (DRAGON)	RGMB	Homo sapiens (Human)	437	FUNCTION: Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. {ECO:0000250|UniProtKB:Q7TQ33, ECO:0000269|PubMed:19324014}.		BMP signaling pathway [GO:0030509]; cell adhesion [GO:0007155]; positive regulation of DNA-templated transcription [GO:0045893]; signal transduction [GO:0007165]	endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]	endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; BMP signaling pathway [GO:0030509]; cell adhesion [GO:0007155]; positive regulation of DNA-templated transcription [GO:0045893]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7TQ33}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q7TQ33}. Membrane raft {ECO:0000250|UniProtKB:Q7TQ33}.
Q6NWY9	reviewed	PR40B_HUMAN	Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C)	PRPF40B HYPC	Homo sapiens (Human)	871	FUNCTION: May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:9700202}.		mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]	nuclear speck [GO:0016607]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]	RNA binding [GO:0003723]	nuclear speck [GO:0016607]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]; RNA binding [GO:0003723]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:10958656}.
Q6NX45	reviewed	ZN774_HUMAN	Zinc finger protein 774	ZNF774	Homo sapiens (Human)	483	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6NXG1	reviewed	ESRP1_HUMAN	Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A)	ESRP1 RBM35A	Homo sapiens (Human)	681	FUNCTION: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). {ECO:0000250|UniProtKB:Q3US41, ECO:0000269|PubMed:19285943}.		mRNA processing [GO:0006397]; regulation of inner ear auditory receptor cell fate specification [GO:0042669]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA binding [GO:0003729]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA binding [GO:0003729]; mRNA processing [GO:0006397]; regulation of inner ear auditory receptor cell fate specification [GO:0042669]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19285943}.
Q6NXS1	reviewed	IPP2B_HUMAN	Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3)	PPP1R2B PPP1R2P3	Homo sapiens (Human)	205	FUNCTION: Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}.		glycogen metabolic process [GO:0005977]; regulation of signal transduction [GO:0009966]		protein phosphatase inhibitor activity [GO:0004864]	protein phosphatase inhibitor activity [GO:0004864]; glycogen metabolic process [GO:0005977]; regulation of signal transduction [GO:0009966]	
Q6NXT2	reviewed	H3C_HUMAN	Histone H3.3C (Histone H3.5)	H3-5 H3F3C	Homo sapiens (Human)	135	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. {ECO:0000269|PubMed:21274551}.		positive regulation of cell growth [GO:0030307]	euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	nucleosomal DNA binding [GO:0031492]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; nucleosomal DNA binding [GO:0031492]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; positive regulation of cell growth [GO:0030307]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q6NXT4	reviewed	ZNT6_HUMAN	Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6)	SLC30A6 ZNT6	Homo sapiens (Human)	461	FUNCTION: Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15994300, PubMed:19366695, PubMed:19759014). As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15994300, PubMed:19759014, PubMed:35525268). {ECO:0000269|PubMed:15994300, ECO:0000269|PubMed:19366695, ECO:0000269|PubMed:19759014, ECO:0000269|PubMed:35525268}.		regulation of zinc ion transport [GO:0071579]; zinc ion import into Golgi lumen [GO:1904257]; zinc ion transport [GO:0006829]	Golgi apparatus [GO:0005794]; trans-Golgi network membrane [GO:0032588]	antiporter activity [GO:0015297]; zinc ion transmembrane transporter activity [GO:0005385]	Golgi apparatus [GO:0005794]; trans-Golgi network membrane [GO:0032588]; antiporter activity [GO:0015297]; zinc ion transmembrane transporter activity [GO:0005385]; regulation of zinc ion transport [GO:0071579]; zinc ion import into Golgi lumen [GO:1904257]; zinc ion transport [GO:0006829]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19366695}; Multi-pass membrane protein {ECO:0000255}.
Q6NXT6	reviewed	TAPT1_HUMAN	Transmembrane anterior posterior transformation protein 1 homolog (Cytomegalovirus partial fusion receptor)	TAPT1 CMVFR	Homo sapiens (Human)	567	FUNCTION: Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). {ECO:0000250|UniProtKB:A2BIE7, ECO:0000250|UniProtKB:Q4VBD2, ECO:0000269|PubMed:26365339}.; FUNCTION: (Microbial infection) In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169. {ECO:0000269|PubMed:10640539}.		cartilage development [GO:0051216]; cell projection organization [GO:0030030]; embryonic skeletal system development [GO:0048706]; neural crest cell development [GO:0014032]; ossification [GO:0001503]; positive regulation of bone development [GO:1903012]; positive regulation of cartilage development [GO:0061036]; positive regulation of cilium assembly [GO:0045724]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	growth hormone-releasing hormone receptor activity [GO:0016520]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; growth hormone-releasing hormone receptor activity [GO:0016520]; cartilage development [GO:0051216]; cell projection organization [GO:0030030]; embryonic skeletal system development [GO:0048706]; neural crest cell development [GO:0014032]; ossification [GO:0001503]; positive regulation of bone development [GO:1903012]; positive regulation of cartilage development [GO:0061036]; positive regulation of cilium assembly [GO:0045724]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26365339}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:26365339}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6NYC1	reviewed	JMJD6_HUMAN	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR)	JMJD6 KIAA0585 PSR PTDSR	Homo sapiens (Human)	403	FUNCTION: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:24498420, PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24498420, PubMed:24360279). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002). {ECO:0000250|UniProtKB:Q9ERI5, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:17947579, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:20679243, ECO:0000269|PubMed:20684070, ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:22189873, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:24498420, ECO:0000269|PubMed:29176719}.		cell surface receptor signaling pathway [GO:0007166]; chromatin remodeling [GO:0006338]; erythrocyte development [GO:0048821]; heart development [GO:0007507]; kidney development [GO:0001822]; lung development [GO:0030324]; macrophage activation [GO:0042116]; mRNA processing [GO:0006397]; negative regulation of protein homooligomerization [GO:0032463]; non-membrane-bounded organelle assembly [GO:0140694]; oxidative RNA demethylation [GO:0035513]; peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine [GO:0018395]; phagocytosis [GO:0006909]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; recognition of apoptotic cell [GO:0043654]; regulation of mRNA splicing, via spliceosome [GO:0048024]; retina development in camera-type eye [GO:0060041]; RNA splicing [GO:0008380]; sprouting angiogenesis [GO:0002040]; T cell differentiation in thymus [GO:0033077]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]	histone demethylase activity [GO:0032452]; histone H3R2 demethylase activity [GO:0033746]; histone H4R3 demethylase activity [GO:0033749]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; oxidative RNA demethylase activity [GO:0035515]; P-TEFb complex binding [GO:0106140]; peptidyl-lysine 5-dioxygenase activity [GO:0070815]; protein demethylase activity [GO:0140457]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; single-stranded RNA binding [GO:0003727]; transcription regulator activator activity [GO:0140537]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; histone demethylase activity [GO:0032452]; histone H3R2 demethylase activity [GO:0033746]; histone H4R3 demethylase activity [GO:0033749]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; oxidative RNA demethylase activity [GO:0035515]; P-TEFb complex binding [GO:0106140]; peptidyl-lysine 5-dioxygenase activity [GO:0070815]; protein demethylase activity [GO:0140457]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; single-stranded RNA binding [GO:0003727]; transcription regulator activator activity [GO:0140537]; cell surface receptor signaling pathway [GO:0007166]; chromatin remodeling [GO:0006338]; erythrocyte development [GO:0048821]; heart development [GO:0007507]; kidney development [GO:0001822]; lung development [GO:0030324]; macrophage activation [GO:0042116]; mRNA processing [GO:0006397]; negative regulation of protein homooligomerization [GO:0032463]; non-membrane-bounded organelle assembly [GO:0140694]; oxidative RNA demethylation [GO:0035513]; peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine [GO:0018395]; phagocytosis [GO:0006909]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; recognition of apoptotic cell [GO:0043654]; regulation of mRNA splicing, via spliceosome [GO:0048024]; retina development in camera-type eye [GO:0060041]; RNA splicing [GO:0008380]; sprouting angiogenesis [GO:0002040]; T cell differentiation in thymus [GO:0033077]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:14729065, ECO:0000269|PubMed:21060799}. Nucleus, nucleolus {ECO:0000269|PubMed:21060799}. Cytoplasm {ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:24498420}. Note=Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle. {ECO:0000269|PubMed:21060799}.
Q6NYC8	reviewed	PPR18_HUMAN	Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18)	PPP1R18 HKMT1098 KIAA1949	Homo sapiens (Human)	613	FUNCTION: [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}.			cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	actin binding [GO:0003779]; phosphatase binding [GO:0019902]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; actin binding [GO:0003779]; phosphatase binding [GO:0019902]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24434620}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17374523}.
Q6NZ36	reviewed	FAP20_HUMAN	Fanconi anemia core complex-associated protein 20 (FANCA-associated protein of 20 kDa) (Fanconi anemia-associated protein of 20 kDa)	FAAP20 C1orf86 FP7162	Homo sapiens (Human)	180	FUNCTION: Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. {ECO:0000269|PubMed:22266823, ECO:0000269|PubMed:22343915, ECO:0000269|PubMed:22396592, ECO:0000269|PubMed:22705371}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	DNA damage response [GO:0006974]; interstrand cross-link repair [GO:0036297]; translesion synthesis [GO:0019985]	cell junction [GO:0030054]; chromatin [GO:0000785]; chromosome [GO:0005694]; Fanconi anaemia nuclear complex [GO:0043240]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; ubiquitin binding [GO:0043130]; ubiquitin-dependent protein binding [GO:0140036]	cell junction [GO:0030054]; chromatin [GO:0000785]; chromosome [GO:0005694]; Fanconi anaemia nuclear complex [GO:0043240]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; ubiquitin binding [GO:0043130]; ubiquitin-dependent protein binding [GO:0140036]; DNA damage response [GO:0006974]; interstrand cross-link repair [GO:0036297]; translesion synthesis [GO:0019985]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22343915, ECO:0000269|PubMed:22705371}. Chromosome {ECO:0000305|PubMed:22343915, ECO:0000305|PubMed:22705371}. Note=Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8. {ECO:0000269|PubMed:22705371}.
Q6NZI2	reviewed	CAVN1_HUMAN	Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor)	CAVIN1 PTRF FKSG13	Homo sapiens (Human)	390	FUNCTION: Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}.		positive regulation of cell motility [GO:2000147]; protein secretion [GO:0009306]; rRNA transcription [GO:0009303]; termination of RNA polymerase I transcription [GO:0006363]; transcription initiation at RNA polymerase I promoter [GO:0006361]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA primary transcript binding [GO:0042134]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA primary transcript binding [GO:0042134]; positive regulation of cell motility [GO:2000147]; protein secretion [GO:0009306]; rRNA transcription [GO:0009303]; termination of RNA polymerase I transcription [GO:0006363]; transcription initiation at RNA polymerase I promoter [GO:0006361]	SUBCELLULAR LOCATION: Membrane, caveola {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:19525939}. Cell membrane {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959, ECO:0000269|PubMed:18056712}. Microsome {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P85125}. Cytoplasm, cytosol {ECO:0000269|PubMed:15242332}. Mitochondrion {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Nucleus {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Note=Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Colocalizes with CAV1 in lipid rafts in adipocytes. Localizes in the caveolae in a caveolin-dependent manner (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:17026959}.
Q6NZY4	reviewed	ZCHC8_HUMAN	Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8)	ZCCHC8	Homo sapiens (Human)	707	FUNCTION: Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}.		mRNA splicing, via spliceosome [GO:0000398]; ncRNA processing [GO:0034470]; snRNA catabolic process [GO:0016076]	catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; mRNA splicing, via spliceosome [GO:0000398]; ncRNA processing [GO:0034470]; snRNA catabolic process [GO:0016076]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:16263084, ECO:0000269|PubMed:21855801}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Note=Excluded from nucleolus. {ECO:0000269|PubMed:21855801}.
Q6NZY7	reviewed	BORG3_HUMAN	Cdc42 effector protein 5 (Binder of Rho GTPases 3)	CDC42EP5 BORG3 CEP5	Homo sapiens (Human)	148	FUNCTION: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity). {ECO:0000250}.		JNK cascade [GO:0007254]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886]	small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886]; small GTPase binding [GO:0031267]; JNK cascade [GO:0007254]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Q6P050	reviewed	FXL22_HUMAN	F-box and leucine-rich protein 22	FBXL22	Homo sapiens (Human)	247	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC). {ECO:0000269|PubMed:22972877}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; nucleolus [GO:0005730]; Z disc [GO:0030018]	ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; nucleolus [GO:0005730]; Z disc [GO:0030018]; ubiquitin protein ligase activity [GO:0061630]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:22972877}.
Q6P087	reviewed	RUSD3_HUMAN	Mitochondrial mRNA pseudouridine synthase RPUSD3 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 3)	RPUSD3	Homo sapiens (Human)	351	FUNCTION: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis (PubMed:27667664). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:27974379}.		mRNA processing [GO:0006397]; positive regulation of mitochondrial translation [GO:0070131]; pseudouridine synthesis [GO:0001522]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]	pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; positive regulation of mitochondrial translation [GO:0070131]; pseudouridine synthesis [GO:0001522]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:27974379}. Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. {ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677}.
Q6P0N0	reviewed	M18BP_HUMAN	Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243)	MIS18BP1 C14orf106 KIAA1903 KNL2 M18BP1	Homo sapiens (Human)	1132	FUNCTION: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}.		cell cycle [GO:0007049]; cell division [GO:0051301]	chromosome, centromeric region [GO:0000775]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]	chromosome, centromeric region [GO:0000775]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; cell cycle [GO:0007049]; cell division [GO:0051301]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17199038}. Chromosome, centromere {ECO:0000269|PubMed:17199038}. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin. {ECO:0000269|PubMed:17199038}.
Q6P0Q8	reviewed	MAST2_HUMAN	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1)	MAST2 KIAA0807 MAST205	Homo sapiens (Human)	1798	FUNCTION: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.		cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of interleukin-12 production [GO:0032655]; spermatid differentiation [GO:0048515]	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; phosphatase binding [GO:0019902]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; phosphatase binding [GO:0019902]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of interleukin-12 production [GO:0032655]; spermatid differentiation [GO:0048515]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12117771}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to the sub-membranous area on interaction with CDHR2.
Q6P158	reviewed	DHX57_HUMAN	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57)	DHX57	Homo sapiens (Human)	1386	FUNCTION: Probable ATP-binding RNA helicase.				ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	
Q6P179	reviewed	ERAP2_HUMAN	Endoplasmic reticulum aminopeptidase 2 (EC 3.4.11.-) (Leukocyte-derived arginine aminopeptidase) (L-RAP)	ERAP2 LRAP	Homo sapiens (Human)	960	FUNCTION: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. {ECO:0000269|PubMed:12799365, ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653}.	MISCELLANEOUS: Defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance.	adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]	cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]	aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]; adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12799365}; Single-pass type II membrane protein {ECO:0000269|PubMed:12799365}.
Q6P1A2	reviewed	MBOA5_HUMAN	Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 3) (Lyso-PC acyltransferase 3) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 5) (O-acyltransferase domain-containing protein 5)	LPCAT3 MBOAT5 OACT5	Homo sapiens (Human)	487	FUNCTION: Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle (PubMed:18782225, PubMed:18195019, PubMed:18772128). Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity) (PubMed:18782225, PubMed:18195019, PubMed:18772128). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (PubMed:18195019, PubMed:18772128). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (By similarity). Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (By similarity). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (By similarity). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (By similarity). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity). {ECO:0000250|UniProtKB:Q91V01, ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128, ECO:0000269|PubMed:18782225}.		chylomicron assembly [GO:0034378]; endoplasmic reticulum membrane organization [GO:0090158]; intestinal stem cell homeostasis [GO:0036335]; lipid modification [GO:0030258]; negative regulation of inflammatory response [GO:0050728]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylserine acyl-chain remodeling [GO:0036150]; positive regulation of intestinal cholesterol absorption [GO:0045797]; positive regulation of triglyceride transport [GO:1905885]; regulation of cholesterol biosynthetic process [GO:0045540]; very-low-density lipoprotein particle assembly [GO:0034379]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; lysophospholipid acyltransferase activity [GO:0071617]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; lysophospholipid acyltransferase activity [GO:0071617]; chylomicron assembly [GO:0034378]; endoplasmic reticulum membrane organization [GO:0090158]; intestinal stem cell homeostasis [GO:0036335]; lipid modification [GO:0030258]; negative regulation of inflammatory response [GO:0050728]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylserine acyl-chain remodeling [GO:0036150]; positive regulation of intestinal cholesterol absorption [GO:0045797]; positive regulation of triglyceride transport [GO:1905885]; regulation of cholesterol biosynthetic process [GO:0045540]; very-low-density lipoprotein particle assembly [GO:0034379]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18195019}; Multi-pass membrane protein {ECO:0000255}.
Q6P1J6	reviewed	PLB1_HUMAN	Phospholipase B1, membrane-associated (Phospholipase B) (hPLB) (Lysophospholipase) (EC 3.1.1.5) (Phospholipase A2) (EC 3.1.1.4) (Phospholipase B/lipase) (PLB/LIP) (Triacylglycerol lipase) (EC 3.1.1.3)	PLB1 PLB	Homo sapiens (Human)	1458	FUNCTION: Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity). {ECO:0000250|UniProtKB:O54728, ECO:0000250|UniProtKB:Q05017}.		diacylglycerol catabolic process [GO:0046340]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338]; phosphatidylglycerol catabolic process [GO:0034478]; phospholipid metabolic process [GO:0006644]; positive regulation of acrosome reaction [GO:2000344]; retinoid metabolic process [GO:0001523]; triglyceride catabolic process [GO:0019433]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]	calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; phospholipase A2 activity [GO:0004623]; retinyl-palmitate esterase activity [GO:0050253]; triglyceride lipase activity [GO:0004806]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; phospholipase A2 activity [GO:0004623]; retinyl-palmitate esterase activity [GO:0050253]; triglyceride lipase activity [GO:0004806]; diacylglycerol catabolic process [GO:0046340]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338]; phosphatidylglycerol catabolic process [GO:0034478]; phospholipid metabolic process [GO:0006644]; positive regulation of acrosome reaction [GO:2000344]; retinoid metabolic process [GO:0001523]; triglyceride catabolic process [GO:0019433]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:O54728}; Single-pass type I membrane protein {ECO:0000255}. Note=Present in the intestinal brush border membranes. {ECO:0000250|UniProtKB:O54728}.
Q6P1J9	reviewed	CDC73_HUMAN	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)	CDC73 C1orf28 HRPT2	Homo sapiens (Human)	531	FUNCTION: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622, ECO:0000269|PubMed:16630820, ECO:0000269|PubMed:16989776, ECO:0000269|PubMed:19136632, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}.		cell cycle [GO:0007049]; cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; mRNA polyadenylation [GO:0006378]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of Wnt signaling pathway [GO:0030177]; protein destabilization [GO:0031648]; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [GO:0034402]; regulation of cell growth [GO:0001558]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055]	Cdc73/Paf1 complex [GO:0016593]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA polymerase II complex binding [GO:0000993]	Cdc73/Paf1 complex [GO:0016593]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II complex binding [GO:0000993]; cell cycle [GO:0007049]; cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; mRNA polyadenylation [GO:0006378]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of Wnt signaling pathway [GO:0030177]; protein destabilization [GO:0031648]; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [GO:0034402]; regulation of cell growth [GO:0001558]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622}.
Q6P1K1	reviewed	HRG1_HUMAN	Heme transporter HRG1 (Heme-responsive gene 1 protein homolog) (HRG-1) (hHRG-1) (Solute carrier family 48 member 1)	SLC48A1 HRG1	Homo sapiens (Human)	146	FUNCTION: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment (PubMed:18418376). In macrophages of the reticuloendothelial system, is the heme transporter for heme-iron recycling. Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP) (PubMed:23395172). {ECO:0000269|PubMed:18418376, ECO:0000269|PubMed:23395172}.		heme transport [GO:0015886]	endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]	endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]; heme transport [GO:0015886]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18418376, ECO:0000269|PubMed:23395172}; Multi-pass membrane protein {ECO:0000269|PubMed:18418376}. Lysosome membrane {ECO:0000269|PubMed:18418376, ECO:0000269|PubMed:23395172}; Multi-pass membrane protein {ECO:0000269|PubMed:18418376}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9D8M3}; Multi-pass membrane protein {ECO:0000255}. Note=In macrophages, specifically localizes to the phagolysosomal membranes during erythrophagocytosis. {ECO:0000250|UniProtKB:Q9D8M3}.
Q6P1K2	reviewed	PMF1_HUMAN	Polyamine-modulated factor 1 (PMF-1)	PMF1	Homo sapiens (Human)	205	FUNCTION: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT. {ECO:0000269|PubMed:10419538, ECO:0000269|PubMed:11256947, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}.		attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; transcription by RNA polymerase II [GO:0006366]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; transcription regulator complex [GO:0005667]	leucine zipper domain binding [GO:0043522]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; transcription regulator complex [GO:0005667]; leucine zipper domain binding [GO:0043522]; transcription coactivator activity [GO:0003713]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16585270}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16585270}. Note=Associated with the kinetochore.
Q6P1L5	reviewed	F117B_HUMAN	Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein)	FAM117B ALS2CR13	Homo sapiens (Human)	589		MISCELLANEOUS: ALS2CR13 is mapped in the genomic region covering the complete candidate region for Amyotrophic lateral sclerosis 2 (ALS2).					
Q6P1L6	reviewed	ZN343_HUMAN	Zinc finger protein 343	ZNF343	Homo sapiens (Human)	599	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6P1M0	reviewed	S27A4_HUMAN	Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 4) (Very long-chain acyl-CoA synthetase 4) (ACSVL4) (EC 6.2.1.-)	SLC27A4 ACSVL4 FATP4	Homo sapiens (Human)	643	FUNCTION: Mediates the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across cell membranes (PubMed:10518211, PubMed:12556534, PubMed:20448275, PubMed:21395585, PubMed:22022213). Appears to be the principal fatty acid transporter in small intestinal enterocytes (PubMed:20448275). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:22022213, PubMed:24269233). Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed:21395585). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). {ECO:0000250|UniProtKB:Q91VE0, ECO:0000269|PubMed:10518211, ECO:0000269|PubMed:12556534, ECO:0000269|PubMed:20448275, ECO:0000269|PubMed:21395585, ECO:0000269|PubMed:22022213, ECO:0000269|PubMed:24269233}.	MISCELLANEOUS: SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4 expression is positively correlated with acquired obesity.	activation of GTPase activity [GO:0090630]; establishment of localization in cell [GO:0051649]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; glucose import in response to insulin stimulus [GO:0044381]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of apoptotic process [GO:0043065]; response to nutrient [GO:0007584]; skin development [GO:0043588]; transport across blood-brain barrier [GO:0150104]; very long-chain fatty acid catabolic process [GO:0042760]	brush border membrane [GO:0031526]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	arachidonate-CoA ligase activity [GO:0047676]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; oleate transmembrane transporter activity [GO:1901480]; oleoyl-CoA ligase activity [GO:0090434]; palmitoyl-CoA ligase activity [GO:0090433]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	brush border membrane [GO:0031526]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; arachidonate-CoA ligase activity [GO:0047676]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; oleate transmembrane transporter activity [GO:1901480]; oleoyl-CoA ligase activity [GO:0090434]; palmitoyl-CoA ligase activity [GO:0090433]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; activation of GTPase activity [GO:0090630]; establishment of localization in cell [GO:0051649]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; glucose import in response to insulin stimulus [GO:0044381]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of apoptotic process [GO:0043065]; response to nutrient [GO:0007584]; skin development [GO:0043588]; transport across blood-brain barrier [GO:0150104]; very long-chain fatty acid catabolic process [GO:0042760]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22022213, ECO:0000305|PubMed:24269233}; Multi-pass membrane protein {ECO:0000255}.
Q6P1M3	reviewed	L2GL2_HUMAN	LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2)	LLGL2	Homo sapiens (Human)	1020	FUNCTION: Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}.	MISCELLANEOUS: Overexpression of LLGL2 inhibits the tight junction formation.	cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; exocytosis [GO:0006887]; leucine transport [GO:0015820]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of Notch signaling pathway [GO:0008593]; regulation of protein secretion [GO:0050708]	adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; PDZ domain binding [GO:0030165]	adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; PDZ domain binding [GO:0030165]; cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; exocytosis [GO:0006887]; leucine transport [GO:0015820]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of Notch signaling pathway [GO:0008593]; regulation of protein secretion [GO:0050708]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15632202}. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
Q6P1N0	reviewed	C2D1A_HUMAN	Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N)	CC2D1A AKI1	Homo sapiens (Human)	951	FUNCTION: Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}.		negative regulation of snRNA transcription by RNA polymerase II [GO:1905381]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of snRNA transcription by RNA polymerase II [GO:1905381]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16033914}. Nucleus {ECO:0000250|UniProtKB:Q66HA5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000303|PubMed:20171170}.
Q6P1Q0	reviewed	LTMD1_HUMAN	LETM1 domain-containing protein 1 (Cervical cancer 1 proto-oncogene protein p40) (Cervical cancer proto-oncogene 2 protein) (HCCR-1) (HCRR-2)	LETMD1	Homo sapiens (Human)	360	FUNCTION: Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (By similarity). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (PubMed:31980577). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (PubMed:12879013). {ECO:0000250|UniProtKB:Q924L1}.		mitochondrion organization [GO:0007005]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of inflammatory response [GO:0050727]; regulation of phagocytosis [GO:0050764]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	molecular adaptor activity [GO:0060090]; ribosome binding [GO:0043022]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; molecular adaptor activity [GO:0060090]; ribosome binding [GO:0043022]; mitochondrion organization [GO:0007005]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of inflammatory response [GO:0050727]; regulation of phagocytosis [GO:0050764]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:17943721, ECO:0000269|PubMed:18045496}; Single-pass membrane protein {ECO:0000269|PubMed:18045496}. Nucleus {ECO:0000250|UniProtKB:Q924L1}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q924L1}; Single-pass membrane protein {ECO:0000255}.
Q6P1Q9	reviewed	MET2B_HUMAN	tRNA N(3)-methylcytidine methyltransferase METTL2B (EC 2.1.1.-) (Methyltransferase-like protein 2B)	METTL2B	Homo sapiens (Human)	378	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). {ECO:0000269|PubMed:28655767}.		tRNA methylation [GO:0030488]	cytoplasm [GO:0005737]	tRNA (cytosine) methyltransferase activity [GO:0016427]; tRNA (cytosine-3-)-methyltransferase activity [GO:0052735]	cytoplasm [GO:0005737]; tRNA (cytosine) methyltransferase activity [GO:0016427]; tRNA (cytosine-3-)-methyltransferase activity [GO:0052735]; tRNA methylation [GO:0030488]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34268557}.
Q6P1W5	reviewed	CA094_HUMAN	Uncharacterized protein C1orf94	C1orf94	Homo sapiens (Human)	598							
Q6P1X5	reviewed	TAF2_HUMAN	Transcription initiation factor TFIID subunit 2 (150 kDa cofactor of initiator function) (RNA polymerase II TBP-associated factor subunit B) (TBP-associated factor 150 kDa) (Transcription initiation factor TFIID 150 kDa subunit) (TAF(II)150) (TAFII-150) (TAFII150)	TAF2 CIF150 TAF2B	Homo sapiens (Human)	1199	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:9418870, PubMed:9774672). TAF2 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF1 (PubMed:9774672, PubMed:33795473). {ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:9418870, ECO:0000269|PubMed:9774672}.	MISCELLANEOUS: PubMed:9418870 was unable to show an association between TAF2 and TFIID.	G2/M transition of mitotic cell cycle [GO:0000086]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; response to organic cyclic compound [GO:0014070]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]	chromatin binding [GO:0003682]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription cis-regulatory region binding [GO:0000976]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; chromatin binding [GO:0003682]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription cis-regulatory region binding [GO:0000976]; G2/M transition of mitotic cell cycle [GO:0000086]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; response to organic cyclic compound [GO:0014070]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9774672}.
Q6P2C8	reviewed	MED27_HUMAN	Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34)	MED27 CRSP34 CRSP8	Homo sapiens (Human)	311	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:10882111, ECO:0000269|PubMed:9989412}.		positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]; transcription initiation at RNA polymerase II promoter [GO:0006367]	core mediator complex [GO:0070847]; cytosol [GO:0005829]; mediator complex [GO:0016592]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ubiquitin ligase complex [GO:0000151]	transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]	core mediator complex [GO:0070847]; cytosol [GO:0005829]; mediator complex [GO:0016592]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ubiquitin ligase complex [GO:0000151]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10882111, ECO:0000269|PubMed:9989412}.
Q6P2D0	reviewed	ZFP1_HUMAN	Zinc finger protein 1 homolog (Zfp-1) (Zinc finger protein 475)	ZFP1 ZNF475	Homo sapiens (Human)	407	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P08042}. Note=Shows widespread expression throughout the nucleus, but appears to be excluded from nucleoli. {ECO:0000250|UniProtKB:P08042}.
Q6P2D8	reviewed	XRRA1_HUMAN	X-ray radiation resistance-associated protein 1	XRRA1	Homo sapiens (Human)	792	FUNCTION: May be involved in the response of cells to X-ray radiation. {ECO:0000269|PubMed:12908878}.	MISCELLANEOUS: [Isoform 1]: Gene model based on mouse cDNA data. {ECO:0000305}.	response to X-ray [GO:0010165]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; response to X-ray [GO:0010165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12908878}. Nucleus {ECO:0000269|PubMed:12908878}.
Q6P2E9	reviewed	EDC4_HUMAN	Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls)	EDC4 HEDLS	Homo sapiens (Human)	1401	FUNCTION: In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}.		deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]		cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:9067524}. Nucleus {ECO:0000269|PubMed:7520377}.
Q6P2H3	reviewed	CEP85_HUMAN	Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21)	CEP85 CCDC21	Homo sapiens (Human)	762	FUNCTION: Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269|PubMed:26220856}.		centriole replication [GO:0007099]; chromosome segregation [GO:0007059]; negative regulation of protein kinase activity [GO:0006469]; regulation of mitotic centrosome separation [GO:0046602]	centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; pericentriolar material [GO:0000242]; spindle pole [GO:0000922]		centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; pericentriolar material [GO:0000242]; spindle pole [GO:0000922]; centriole replication [GO:0007099]; chromosome segregation [GO:0007059]; negative regulation of protein kinase activity [GO:0006469]; regulation of mitotic centrosome separation [GO:0046602]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:26220856}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:26220856}. Nucleus, nucleolus {ECO:0000269|PubMed:21399614}. Note=Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates at spindle poles (PubMed:21399614). Associated with the pericentriolar material. Localizes to centrosomes at a low level in G1 phase and a slightly increased level in S phase, with gradually elevated levels during G2 phase. The levels at centrosomes further increase at G2/M, reaching a peak at spindle poles at early mitotic stages and remain high until the end of anaphase (PubMed:26220856). {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:26220856}.
Q6P2H8	reviewed	TMM53_HUMAN	Transmembrane protein 53 (Nuclear envelope transmembrane protein 4)	TMEM53 NET4	Homo sapiens (Human)	277	FUNCTION: Ensures normal bone formation, through the negative regulation of bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD1/5/9 proteins. {ECO:0000269|PubMed:33824347}.		negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; regulation of nucleocytoplasmic transport [GO:0046822]	nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleus [GO:0005634]		nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleus [GO:0005634]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; regulation of nucleocytoplasmic transport [GO:0046822]	SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000269|PubMed:33824347}; Single-pass membrane protein {ECO:0000305}.
Q6P2M8	reviewed	KCC1B_HUMAN	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase I beta) (CaM kinase IB) (CaM-KI beta) (CaMKI-beta) (Pregnancy up-regulated non-ubiquitously-expressed CaM kinase)	PNCK	Homo sapiens (Human)	343	FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity). {ECO:0000250}.		phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q6P2P2	reviewed	ANM9_HUMAN	Protein arginine N-methyltransferase 9 (Protein arginine N-methyltransferase 10) (EC 2.1.1.320)	PRMT9 PRMT10	Homo sapiens (Human)	845	FUNCTION: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344). {ECO:0000269|PubMed:25737013, ECO:0000269|PubMed:25979344}.		methylation [GO:0032259]; mRNA processing [GO:0006397]	cytoplasm [GO:0005737]	protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243]	cytoplasm [GO:0005737]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243]; methylation [GO:0032259]; mRNA processing [GO:0006397]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25737013, ECO:0000269|PubMed:25979344}.
Q6P2Q9	reviewed	PRP8_HUMAN	Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)	PRPF8 PRPC8	Homo sapiens (Human)	2335	FUNCTION: Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. {ECO:0000269|PubMed:10411133, ECO:0000269|PubMed:11971955, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000303|PubMed:15840809}.		cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453}. Nucleus speckle {ECO:0000305}.
Q6P3S1	reviewed	DEN1B_HUMAN	DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B)	DENND1B C1orf218 FAM31B	Homo sapiens (Human)	775	FUNCTION: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}.		endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; protein transport [GO:0015031]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]	guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; protein transport [GO:0015031]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20154091}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:20154091}.
Q6P3W2	reviewed	DJC24_HUMAN	DnaJ homolog subfamily C member 24 (CSL-type zinc finger-containing protein 3) (Diphthamide biosynthesis protein 4)	DNAJC24 DPH4 ZCSL3	Homo sapiens (Human)	149	FUNCTION: Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000269|PubMed:22367199, ECO:0000269|PubMed:22509046}.		chaperone-mediated protein folding [GO:0061077]; positive regulation of ATP-dependent activity [GO:0032781]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	ATPase activator activity [GO:0001671]; ferrous iron binding [GO:0008198]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; ATPase activator activity [GO:0001671]; ferrous iron binding [GO:0008198]; zinc ion binding [GO:0008270]; chaperone-mediated protein folding [GO:0061077]; positive regulation of ATP-dependent activity [GO:0032781]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q6P3W7	reviewed	SCYL2_HUMAN	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa)	SCYL2 CVAK104 KIAA1360	Homo sapiens (Human)	929	FUNCTION: Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (PubMed:15809293, PubMed:16914521). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity). {ECO:0000250|UniProtKB:Q8CFE4, ECO:0000269|PubMed:15809293, ECO:0000269|PubMed:16914521, ECO:0000305|PubMed:15809293, ECO:0000305|PubMed:16914521}.		brain development [GO:0007420]; endosome to lysosome transport [GO:0008333]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of receptor internalization [GO:0002092]; pyramidal neuron development [GO:0021860]; receptor internalization involved in canonical Wnt signaling pathway [GO:2000286]	clathrin-coated vesicle [GO:0030136]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102]	clathrin-coated vesicle [GO:0030136]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102]; brain development [GO:0007420]; endosome to lysosome transport [GO:0008333]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of receptor internalization [GO:0002092]; pyramidal neuron development [GO:0021860]; receptor internalization involved in canonical Wnt signaling pathway [GO:2000286]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:15809293, ECO:0000269|PubMed:16914521}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16914521}. Endosome membrane {ECO:0000269|PubMed:16914521}. Note=Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes. {ECO:0000269|PubMed:16914521}.
Q6P461	reviewed	ACSM6_HUMAN	Acyl-coenzyme A synthetase ACSM6, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 6)	ACSM6 C10orf129	Homo sapiens (Human)	480	FUNCTION: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. {ECO:0000250|UniProtKB:Q08AH1}.		acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]	mitochondrial matrix [GO:0005759]	ATP binding [GO:0005524]; butyrate-CoA ligase activity [GO:0047760]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; GTP binding [GO:0005525]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; metal ion binding [GO:0046872]	mitochondrial matrix [GO:0005759]; ATP binding [GO:0005524]; butyrate-CoA ligase activity [GO:0047760]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; GTP binding [GO:0005525]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; metal ion binding [GO:0046872]; acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q6P4A7	reviewed	SFXN4_HUMAN	Sideroflexin-4 (Breast cancer resistance marker 1)	SFXN4 BCRM1	Homo sapiens (Human)	337	FUNCTION: Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (PubMed:30442778). {ECO:0000250|UniProtKB:Q9H9B4, ECO:0000269|PubMed:30442778}.		amino acid transport [GO:0006865]; mitochondrial transmembrane transport [GO:1990542]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	monoatomic ion transmembrane transporter activity [GO:0015075]; transmembrane transporter activity [GO:0022857]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; monoatomic ion transmembrane transporter activity [GO:0015075]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865]; mitochondrial transmembrane transport [GO:1990542]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:24119684, ECO:0000305|PubMed:30442778}; Multi-pass membrane protein {ECO:0000255}.
Q6P4A8	reviewed	PLBL1_HUMAN	Phospholipase B-like 1 (EC 3.1.1.-) (LAMA-like protein 1) (Lamina ancestor homolog 1) (Phospholipase B domain-containing protein 1) [Cleaved into: Phospholipase B-like 1 chain A; Phospholipase B-like 1 chain B; Phospholipase B-like 1 chain C]	PLBD1	Homo sapiens (Human)	553	FUNCTION: In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids. {ECO:0000250, ECO:0000269|PubMed:19019078}.		phospholipid catabolic process [GO:0009395]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]	phospholipase activity [GO:0004620]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; phospholipase activity [GO:0004620]; phospholipid catabolic process [GO:0009395]	SUBCELLULAR LOCATION: Lysosome {ECO:0000250}.
Q6P4F1	reviewed	FUT10_HUMAN	Alpha-(1,3)-fucosyltransferase 10 (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)	FUT10	Homo sapiens (Human)	479	FUNCTION: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. Postulated to generate core alpha(1->3)-fucose epitope within the chitobiose unit of biantennary N-glycans, providing for a recognition signal to reorient aberrantly folded glycoproteins for degradation (PubMed:19088067). Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (By similarity). {ECO:0000250|UniProtKB:Q5F2L2, ECO:0000269|PubMed:19088067}.; FUNCTION: [Isoform 1]: Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit. {ECO:0000269|PubMed:19088067}.; FUNCTION: [Isoform 4]: Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit. {ECO:0000269|PubMed:19088067}.; FUNCTION: [Isoform 5]: Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit. {ECO:0000269|PubMed:19088067}.		cerebral cortex radially oriented cell migration [GO:0021799]; fertilization [GO:0009566]; fucosylation [GO:0036065]; hemopoiesis [GO:0030097]; L-fucose catabolic process [GO:0042355]; N-glycan fucosylation [GO:0036071]; nervous system development [GO:0007399]; neuroblast migration [GO:0097402]; neuronal stem cell division [GO:0036445]; neuronal stem cell population maintenance [GO:0097150]; oligosaccharide biosynthetic process [GO:0009312]; protein folding [GO:0006457]; protein glycosylation [GO:0006486]; protein targeting [GO:0006605]; wound healing [GO:0042060]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]	alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]; cerebral cortex radially oriented cell migration [GO:0021799]; fertilization [GO:0009566]; fucosylation [GO:0036065]; hemopoiesis [GO:0030097]; L-fucose catabolic process [GO:0042355]; N-glycan fucosylation [GO:0036071]; nervous system development [GO:0007399]; neuroblast migration [GO:0097402]; neuronal stem cell division [GO:0036445]; neuronal stem cell population maintenance [GO:0097150]; oligosaccharide biosynthetic process [GO:0009312]; protein folding [GO:0006457]; protein glycosylation [GO:0006486]; protein targeting [GO:0006605]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000305|PubMed:19088067}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000305|PubMed:12370785, ECO:0000305|PubMed:19088067}; Single-pass type II membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 4]: Golgi apparatus {ECO:0000269|PubMed:19088067}. Lysosome {ECO:0000269|PubMed:19088067}.; SUBCELLULAR LOCATION: [Isoform 5]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19088067}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000305|PubMed:19088067}; Single-pass type II membrane protein {ECO:0000255}.
Q6P4F2	reviewed	FDX2_HUMAN	Ferredoxin-2, mitochondrial (Adrenodoxin-like protein) (Ferredoxin-1-like protein)	FDX2 FDX1L	Homo sapiens (Human)	186	FUNCTION: Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:28001042). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). {ECO:0000250|UniProtKB:Q9H1K1, ECO:0000269|PubMed:28001042}.		[2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; electron transport chain [GO:0022900]; iron-sulfur cluster assembly [GO:0016226]; P450-containing electron transport chain [GO:0140647]	iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]	iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; [2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; electron transport chain [GO:0022900]; iron-sulfur cluster assembly [GO:0016226]; P450-containing electron transport chain [GO:0140647]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:24281368}. Mitochondrion matrix {ECO:0000250|UniProtKB:P10109}.
Q6P4H8	reviewed	ACKMT_HUMAN	ATP synthase subunit C lysine N-methyltransferase (EC 2.1.1.-) (Protein N-lysine methyltransferase FAM173B) (hFAM173B)	ATPSCKMT FAM173B	Homo sapiens (Human)	233	FUNCTION: Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090). {ECO:0000269|PubMed:29444090, ECO:0000269|PubMed:30530489}.		peptidyl-lysine methylation [GO:0018022]; peptidyl-lysine trimethylation [GO:0018023]; positive regulation of proton-transporting ATP synthase activity, rotational mechanism [GO:1905273]; positive regulation of sensory perception of pain [GO:1904058]; regulation of mitochondrial ATP synthesis coupled proton transport [GO:1905706]	mitochondrial crista [GO:0030061]; mitochondrion [GO:0005739]	histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279]	mitochondrial crista [GO:0030061]; mitochondrion [GO:0005739]; histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279]; peptidyl-lysine methylation [GO:0018022]; peptidyl-lysine trimethylation [GO:0018023]; positive regulation of proton-transporting ATP synthase activity, rotational mechanism [GO:1905273]; positive regulation of sensory perception of pain [GO:1904058]; regulation of mitochondrial ATP synthesis coupled proton transport [GO:1905706]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:30530489, ECO:0000305|PubMed:29444090}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to mitochondrial cristae. {ECO:0000269|PubMed:29444090}.
Q6P4I2	reviewed	WDR73_HUMAN	WD repeat-containing protein 73	WDR73 HSPC264	Homo sapiens (Human)	378	FUNCTION: May play a role in the regulation of microtubule organization and dynamics (PubMed:25466283). {ECO:0000269|PubMed:25466283}.		cytoplasmic microtubule organization [GO:0031122]; negative regulation of apoptotic process [GO:0043066]; nucleus organization [GO:0006997]	cleavage furrow [GO:0032154]; cytosol [GO:0005829]; spindle pole [GO:0000922]		cleavage furrow [GO:0032154]; cytosol [GO:0005829]; spindle pole [GO:0000922]; cytoplasmic microtubule organization [GO:0031122]; negative regulation of apoptotic process [GO:0043066]; nucleus organization [GO:0006997]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25466283}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:25466283}. Cleavage furrow {ECO:0000269|PubMed:25466283}. Note=During interphase, located in the cytosol. During mitosis, accumulates at the spindle poles and microtubule asters and later in the cleavage furrow. {ECO:0000269|PubMed:25466283}.
Q6P4Q7	reviewed	CNNM4_HUMAN	Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4)	CNNM4 ACDP4 KIAA1592	Homo sapiens (Human)	775	FUNCTION: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. {ECO:0000250, ECO:0000269|PubMed:19200525, ECO:0000269|PubMed:19200527}.	MISCELLANEOUS: Shares weak sequence similarity with the cyclin family, explaining its name. However, it has no cyclin-like function in vivo.	enamel mineralization [GO:0070166]; intracellular monoatomic cation homeostasis [GO:0030003]; magnesium ion homeostasis [GO:0010960]; magnesium ion transport [GO:0015693]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	magnesium ion transmembrane transporter activity [GO:0015095]; sodium ion transmembrane transporter activity [GO:0015081]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; magnesium ion transmembrane transporter activity [GO:0015095]; sodium ion transmembrane transporter activity [GO:0015081]; enamel mineralization [GO:0070166]; intracellular monoatomic cation homeostasis [GO:0030003]; magnesium ion homeostasis [GO:0010960]; magnesium ion transport [GO:0015693]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22399287}; Multi-pass membrane protein {ECO:0000269|PubMed:22399287}.
Q6P4R8	reviewed	NFRKB_HUMAN	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G)	NFRKB INO80G	Homo sapiens (Human)	1299	FUNCTION: Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}.		chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protease binding [GO:0002020]	Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protease binding [GO:0002020]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18922472}.
Q6P531	reviewed	GGT6_HUMAN	Glutathione hydrolase 6 (EC 3.4.19.13) (Gamma-glutamyltransferase 6) (GGT 6) (EC 2.3.2.2) (Gamma-glutamyltranspeptidase 6) [Cleaved into: Glutathione hydrolase 6 heavy chain; Glutathione hydrolase 6 light chain]	GGT6	Homo sapiens (Human)	493	FUNCTION: Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. {ECO:0000250|UniProtKB:P19440}.		glutathione biosynthetic process [GO:0006750]; leukotriene D4 biosynthetic process [GO:1901750]	extracellular exosome [GO:0070062]; membrane [GO:0016020]	glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; glutathione biosynthetic process [GO:0006750]; leukotriene D4 biosynthetic process [GO:1901750]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P19440}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P07314}.
Q6P587	reviewed	FAHD1_HUMAN	Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1) (FAH domain-containing protein 1) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.112) (YisK-like protein)	FAHD1 C16orf36 YISKL	Homo sapiens (Human)	224	FUNCTION: Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (PubMed:15551868, PubMed:21878618). Also has oxaloacetate decarboxylase activity (PubMed:25575590). {ECO:0000269|PubMed:15551868, ECO:0000269|PubMed:21878618, ECO:0000269|PubMed:25575590}.		pyruvate metabolic process [GO:0006090]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	acetylpyruvate hydrolase activity [GO:0018773]; acylpyruvate hydrolase activity [GO:0047621]; fumarylpyruvate hydrolase activity [GO:0034545]; metal ion binding [GO:0046872]; oxaloacetate decarboxylase activity [GO:0008948]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; acetylpyruvate hydrolase activity [GO:0018773]; acylpyruvate hydrolase activity [GO:0047621]; fumarylpyruvate hydrolase activity [GO:0034545]; metal ion binding [GO:0046872]; oxaloacetate decarboxylase activity [GO:0008948]; pyruvate metabolic process [GO:0006090]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21878618}. Cytoplasm, cytosol {ECO:0000269|PubMed:21878618}.
Q6P589	reviewed	TP8L2_HUMAN	Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2) (Inflammation factor protein 20)	TNFAIP8L2	Homo sapiens (Human)	184	FUNCTION: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis (PubMed:27043859). Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (PubMed:32188758). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (PubMed:32460619). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity). {ECO:0000250|UniProtKB:Q9D8Y7, ECO:0000269|PubMed:27043859, ECO:0000269|PubMed:32188758, ECO:0000269|PubMed:32460619}.		innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of T cell activation [GO:0050868]; regulation of apoptotic process [GO:0042981]; T cell activation [GO:0042110]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of T cell activation [GO:0050868]; regulation of apoptotic process [GO:0042981]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21459448, ECO:0000269|PubMed:27043859, ECO:0000269|PubMed:32460619}. Nucleus {ECO:0000269|PubMed:21459448, ECO:0000269|PubMed:27043859}. Lysosome {ECO:0000269|PubMed:32460619}.
Q6P597	reviewed	KLC3_HUMAN	Kinesin light chain 3 (KLC2-like) (kinesin light chain 2)	KLC3 KLC2 KLC2L	Homo sapiens (Human)	504	FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity). {ECO:0000250|UniProtKB:Q91W40}.		axo-dendritic transport [GO:0008088]; microtubule-based movement [GO:0007018]; sperm mitochondrial sheath assembly [GO:0120317]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; neuron projection [GO:0043005]	kinesin binding [GO:0019894]; microtubule binding [GO:0008017]	ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; axo-dendritic transport [GO:0008088]; microtubule-based movement [GO:0007018]; sperm mitochondrial sheath assembly [GO:0120317]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q68G30, ECO:0000250|UniProtKB:Q91W40}. Mitochondrion {ECO:0000250|UniProtKB:Q91W40}. Note=In elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria. Also localizes to the manchette in elongating spermatids. {ECO:0000250|UniProtKB:Q68G30, ECO:0000250|UniProtKB:Q91W40}.
Q6P5Q4	reviewed	LMOD2_HUMAN	Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin)	LMOD2	Homo sapiens (Human)	547	FUNCTION: Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:26370058, PubMed:25250574, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713). {ECO:0000250|UniProtKB:Q3UHZ5, ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:25250574, ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:26417072}.		actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of actin filament polymerization [GO:0030838]; sarcomere organization [GO:0045214]	actin filament [GO:0005884]; cytoskeleton [GO:0005856]; M band [GO:0031430]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]	actin binding [GO:0003779]; actin monomer binding [GO:0003785]; tropomyosin binding [GO:0005523]	actin filament [GO:0005884]; cytoskeleton [GO:0005856]; M band [GO:0031430]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]; actin binding [GO:0003779]; actin monomer binding [GO:0003785]; tropomyosin binding [GO:0005523]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of actin filament polymerization [GO:0030838]; sarcomere organization [GO:0045214]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:20685966, ECO:0000269|PubMed:26370058}. Cytoplasm, myofibril {ECO:0000269|PubMed:20685966}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:20685966}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26370058}. Note=Colocalizes with actin filaments in sarcomeres. Detected close to the M line. {ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:20685966, ECO:0000269|PubMed:26370058}.
Q6P5S7	reviewed	RNK_HUMAN	Ribonuclease kappa (RNase K) (RNase kappa) (EC 3.1.-.-) (V-type proton ATPase subunit f) (V-ATPase subunit f)	RNASEK	Homo sapiens (Human)	137	FUNCTION: Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate (PubMed:17881363). Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:26212330). Required at an early stage of receptor-mediated endocytosis (PubMed:26212330). {ECO:0000269|PubMed:17881363, ECO:0000269|PubMed:26212330}.; FUNCTION: (Microbial infection) Required at an early stage of both clathrin-mediated and clathrin-independent endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, influenza, and human rhinoviruses (PubMed:26056282, PubMed:26212330). {ECO:0000269|PubMed:26056282, ECO:0000269|PubMed:26212330}.		endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; proton transmembrane transport [GO:1902600]; receptor-mediated endocytosis [GO:0006898]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; vacuolar acidification [GO:0007035]	clathrin-coated vesicle membrane [GO:0030665]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	RNA endonuclease activity [GO:0004521]	clathrin-coated vesicle membrane [GO:0030665]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; RNA endonuclease activity [GO:0004521]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; proton transmembrane transport [GO:1902600]; receptor-mediated endocytosis [GO:0006898]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:26212330}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q3ZC23}; Multi-pass membrane protein {ECO:0000255}.
Q6P5W5	reviewed	S39A4_HUMAN	Zinc transporter ZIP4 (Solute carrier family 39 member 4) (Zrt- and Irt-like protein 4) (ZIP-4)	SLC39A4 ZIP4	Homo sapiens (Human)	647	FUNCTION: Selective transporter that mediates the uptake of Zn(2+) (PubMed:17202136, PubMed:22242765, PubMed:27321477, PubMed:28875161, PubMed:31164399, PubMed:31914589, PubMed:31979155, PubMed:33837739, PubMed:36473915). Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability (PubMed:32348750, PubMed:17202136). Exhibits also polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:22242765, PubMed:31914589). {ECO:0000250|UniProtKB:Q78IQ7, ECO:0000269|PubMed:17202136, ECO:0000269|PubMed:22242765, ECO:0000269|PubMed:27321477, ECO:0000269|PubMed:28875161, ECO:0000269|PubMed:31164399, ECO:0000269|PubMed:31914589, ECO:0000269|PubMed:31979155, ECO:0000269|PubMed:32348750, ECO:0000269|PubMed:33837739, ECO:0000269|PubMed:36473915}.		cellular response to zinc ion starvation [GO:0034224]; intracellular zinc ion homeostasis [GO:0006882]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion binding [GO:0008270]; zinc ion sensor activity [GO:0106219]; zinc ion sequestering activity [GO:0140486]; zinc ion transmembrane transporter activity [GO:0005385]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion binding [GO:0008270]; zinc ion sensor activity [GO:0106219]; zinc ion sequestering activity [GO:0140486]; zinc ion transmembrane transporter activity [GO:0005385]; cellular response to zinc ion starvation [GO:0034224]; intracellular zinc ion homeostasis [GO:0006882]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14612438, ECO:0000269|PubMed:17202136, ECO:0000269|PubMed:30874431, ECO:0000269|PubMed:31164399, ECO:0000269|PubMed:32348750, ECO:0000269|PubMed:36473915}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Recycling endosome membrane {ECO:0000269|PubMed:14612438}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Apical cell membrane {ECO:0000250|UniProtKB:Q78IQ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to Zn(2+) availability. Zn(2+) deficiency promotes accumulation of SLC39A4 on the surface membrane, whereas high extracellular Zn(2+) levels induce internalization of SLC39A4, but also trigger drastic removal of cellular SLC39A4 via proteasomal and lysosomal degradation pathways. {ECO:0000250|UniProtKB:Q78IQ7, ECO:0000269|PubMed:17202136, ECO:0000269|PubMed:32348750}.
Q6P5X5	reviewed	CV039_HUMAN	UPF0545 protein C22orf39	C22orf39	Homo sapiens (Human)	142							
Q6P5Z2	reviewed	PKN3_HUMAN	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3)	PKN3 PKNBETA	Homo sapiens (Human)	889	FUNCTION: Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}.		epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]; epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10441506}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10441506}. Note=Nuclear and perinuclear Golgi region.
Q6P6C2	reviewed	ALKB5_HUMAN	RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5)	ALKBH5 ABH5 OFOXD1	Homo sapiens (Human)	394	FUNCTION: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178}.		cell differentiation [GO:0030154]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; oxidative single-stranded RNA demethylation [GO:0035553]; regulation of mRNA stability [GO:0043488]; response to hypoxia [GO:0001666]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; metal ion binding [GO:0046872]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931]; oxidative RNA demethylase activity [GO:0035515]; RNA binding [GO:0003723]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; metal ion binding [GO:0046872]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931]; oxidative RNA demethylase activity [GO:0035515]; RNA binding [GO:0003723]; cell differentiation [GO:0030154]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; oxidative single-stranded RNA demethylation [GO:0035553]; regulation of mRNA stability [GO:0043488]; response to hypoxia [GO:0001666]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736}.
Q6P988	reviewed	NOTUM_HUMAN	Palmitoleoyl-protein carboxylesterase NOTUM (EC 3.1.1.98) (hNOTUM)	NOTUM OK/SW-CL.30	Homo sapiens (Human)	496	FUNCTION: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175). {ECO:0000269|PubMed:25731175}.		bone development [GO:0060348]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Wnt signaling pathway [GO:0030178]; protein depalmitoleylation [GO:1990697]; regulation of bone mineralization [GO:0030500]; Wnt signaling pathway [GO:0016055]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]	palmitoleyl hydrolase activity [GO:1990699]; phospholipase C activity [GO:0004629]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; palmitoleyl hydrolase activity [GO:1990699]; phospholipase C activity [GO:0004629]; bone development [GO:0060348]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Wnt signaling pathway [GO:0030178]; protein depalmitoleylation [GO:1990697]; regulation of bone mineralization [GO:0030500]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9VUX3}.
Q6P9A2	reviewed	GLT18_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 18 (EC 2.4.1.41) (Polypeptide GalNAc transferase 18) (GalNAc-T18) (Polypeptide GalNAc transferase-like protein 4) (GalNAc-T-like protein 4) (pp-GaNTase-like protein 4) (Polypeptide N-acetylgalactosaminyltransferase-like protein 4) (Protein-UDP acetylgalactosaminyltransferase-like protein 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4)	GALNT18 GALNTL4	Homo sapiens (Human)	607	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor. {ECO:0000269|PubMed:22186971}.		protein O-linked glycosylation [GO:0006493]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q6P9B6	reviewed	MEAK7_HUMAN	MTOR-associated protein MEAK7 (MEAK7) (MTOR associated protein, eak-7 homolog) (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1)	MEAK7 KIAA1609 TLDC1	Homo sapiens (Human)	456	FUNCTION: Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193). {ECO:0000269|PubMed:29750193}.		negative regulation of cellular response to oxidative stress [GO:1900408]; positive regulation of protein localization to lysosome [GO:0150032]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; response to amino acid [GO:0043200]; response to insulin [GO:0032868]; response to nutrient levels [GO:0031667]; TOR signaling [GO:0031929]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; negative regulation of cellular response to oxidative stress [GO:1900408]; positive regulation of protein localization to lysosome [GO:0150032]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; response to amino acid [GO:0043200]; response to insulin [GO:0032868]; response to nutrient levels [GO:0031667]; TOR signaling [GO:0031929]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24223779}. Cytoplasm {ECO:0000269|PubMed:24223779}. Lysosome {ECO:0000269|PubMed:29750193}.
Q6P9B9	reviewed	INT5_HUMAN	Integrator complex subunit 5 (Int5)	INTS5 KIAA1698	Homo sapiens (Human)	1019	FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.		regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:23904267}. Cytoplasm {ECO:0000269|PubMed:23904267}.
Q6P9F0	reviewed	CCD62_HUMAN	Coiled-coil domain-containing protein 62 (Protein TSP-NY) (Protein aaa)	CCDC62	Homo sapiens (Human)	684	FUNCTION: Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. Required for normal spermiogenesis. It probably plays a role in acrosome formation (By similarity). {ECO:0000250|UniProtKB:E9PVD1, ECO:0000269|PubMed:19126643}.		blastocyst hatching [GO:0001835]; cellular response to estradiol stimulus [GO:0071392]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spermatid development [GO:0007286]	acrosomal vesicle [GO:0001669]; nucleus [GO:0005634]	nuclear estrogen receptor binding [GO:0030331]; nuclear receptor coactivator activity [GO:0030374]	acrosomal vesicle [GO:0001669]; nucleus [GO:0005634]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor coactivator activity [GO:0030374]; blastocyst hatching [GO:0001835]; cellular response to estradiol stimulus [GO:0071392]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19126643}. Nucleus {ECO:0000269|PubMed:19126643}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:28339613}. Note=Mainly nuclear.
Q6P9F5	reviewed	TRI40_HUMAN	E3 ubiquitin ligase TRIM40 (EC 2.3.2.27) (Probable E3 NEDD8-protein ligase) (RING finger protein 35)	TRIM40 RNF35	Homo sapiens (Human)	258	FUNCTION: E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response (PubMed:21474709, PubMed:29117565). Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation (PubMed:21474709). Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation (PubMed:21474709). {ECO:0000269|PubMed:21474709, ECO:0000269|PubMed:29117565}.		innate immune response [GO:0045087]; negative regulation of cell growth [GO:0030308]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein localization to nucleus [GO:1900181]; protein neddylation [GO:0045116]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; IkappaB kinase complex [GO:0008385]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; IkappaB kinase complex [GO:0008385]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; negative regulation of cell growth [GO:0030308]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein localization to nucleus [GO:1900181]; protein neddylation [GO:0045116]; protein ubiquitination [GO:0016567]	
Q6P9F7	reviewed	LRC8B_HUMAN	Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP)	LRRC8B KIAA0231 UNQ6413/PRO21207	Homo sapiens (Human)	803	FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}.		monoatomic anion transmembrane transport [GO:0098656]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]; monoatomic anion transmembrane transport [GO:0098656]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:24790029}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO:0000269|PubMed:24790029}.
Q6P9G9	reviewed	ZN449_HUMAN	Zinc finger protein 449 (Zinc finger and SCAN domain-containing protein 19)	ZNF449 ZSCAN19	Homo sapiens (Human)	518	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]; spermatogonial cell division [GO:0007284]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogonial cell division [GO:0007284]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q6P9H4	reviewed	CNKR3_HUMAN	Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein)	CNKSR3 MAGI1	Homo sapiens (Human)	555	FUNCTION: Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC). {ECO:0000269|PubMed:22851176}.		negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of sodium ion transport [GO:0010765]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]		apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of sodium ion transport [GO:0010765]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22851176}. Apical cell membrane {ECO:0000269|PubMed:22851176}; Peripheral membrane protein {ECO:0000269|PubMed:22851176}.
Q6PCB0	reviewed	VWA1_HUMAN	von Willebrand factor A domain-containing protein 1	VWA1	Homo sapiens (Human)	445	FUNCTION: Promotes matrix assembly (By similarity). Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions (Probable). {ECO:0000250|UniProtKB:Q8R2Z5, ECO:0000305|PubMed:33559681}.		behavioral response to pain [GO:0048266]; extracellular matrix organization [GO:0030198]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; interstitial matrix [GO:0005614]	identical protein binding [GO:0042802]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; interstitial matrix [GO:0005614]; identical protein binding [GO:0042802]; behavioral response to pain [GO:0048266]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:Q8R2Z5}.
Q6PCB6	reviewed	AB17C_HUMAN	Alpha/beta hydrolase domain-containing protein 17C (Abhydrolase domain-containing protein 17C) (EC 3.1.2.22)	ABHD17C FAM108C1	Homo sapiens (Human)	329	FUNCTION: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. {ECO:0000269|PubMed:26701913}.		negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; protein depalmitoylation [GO:0002084]; regulation of postsynapse organization [GO:0099175]	dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; recycling endosome membrane [GO:0055038]	palmitoyl-(protein) hydrolase activity [GO:0008474]	dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; recycling endosome membrane [GO:0055038]; palmitoyl-(protein) hydrolase activity [GO:0008474]; negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; protein depalmitoylation [GO:0002084]; regulation of postsynapse organization [GO:0099175]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:B5DFK7}; Lipid-anchor {ECO:0000250|UniProtKB:B5DFK7}; Cytoplasmic side {ECO:0000250|UniProtKB:B5DFK7}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:B5DFK7}. Postsynaptic density membrane {ECO:0000250|UniProtKB:B5DFK7}.
Q6PCB7	reviewed	S27A1_HUMAN	Long-chain fatty acid transport protein 1 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 1) (FATP-1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 1) (Very long-chain acyl-CoA synthetase) (EC 6.2.1.-)	SLC27A1 ACSVL5 FATP1	Homo sapiens (Human)	646	FUNCTION: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:12556534, PubMed:20530735, PubMed:21395585, PubMed:28178239). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed:21395585). {ECO:0000250|UniProtKB:Q60714, ECO:0000269|PubMed:12556534, ECO:0000269|PubMed:20530735, ECO:0000269|PubMed:21395585, ECO:0000269|PubMed:28178239}.		adiponectin-activated signaling pathway [GO:0033211]; biotin import across plasma membrane [GO:1905135]; biotin transport [GO:0015878]; cardiolipin biosynthetic process [GO:0032049]; export across plasma membrane [GO:0140115]; glucose import in response to insulin stimulus [GO:0044381]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid import across plasma membrane [GO:0015911]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; negative regulation of phospholipid biosynthetic process [GO:0071072]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphatidylglycerol biosynthetic process [GO:0006655]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylserine biosynthetic process [GO:0006659]; positive regulation of heat generation [GO:0031652]; positive regulation of triglyceride biosynthetic process [GO:0010867]; response to cold [GO:0009409]; response to insulin [GO:0032868]; transport across blood-brain barrier [GO:0150104]	basal plasma membrane [GO:0009925]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; plasma membrane [GO:0005886]	arachidonate-CoA ligase activity [GO:0047676]; biotin transmembrane transporter activity [GO:0015225]; efflux transmembrane transporter activity [GO:0015562]; fatty acid transmembrane transporter activity [GO:0015245]; identical protein binding [GO:0042802]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; oleate transmembrane transporter activity [GO:1901480]; oleoyl-CoA ligase activity [GO:0090434]; protein serine/threonine kinase activator activity [GO:0043539]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	basal plasma membrane [GO:0009925]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; plasma membrane [GO:0005886]; arachidonate-CoA ligase activity [GO:0047676]; biotin transmembrane transporter activity [GO:0015225]; efflux transmembrane transporter activity [GO:0015562]; fatty acid transmembrane transporter activity [GO:0015245]; identical protein binding [GO:0042802]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; oleate transmembrane transporter activity [GO:1901480]; oleoyl-CoA ligase activity [GO:0090434]; protein serine/threonine kinase activator activity [GO:0043539]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; adiponectin-activated signaling pathway [GO:0033211]; biotin import across plasma membrane [GO:1905135]; biotin transport [GO:0015878]; cardiolipin biosynthetic process [GO:0032049]; export across plasma membrane [GO:0140115]; glucose import in response to insulin stimulus [GO:0044381]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid import across plasma membrane [GO:0015911]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; negative regulation of phospholipid biosynthetic process [GO:0071072]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphatidylglycerol biosynthetic process [GO:0006655]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylserine biosynthetic process [GO:0006659]; positive regulation of heat generation [GO:0031652]; positive regulation of triglyceride biosynthetic process [GO:0010867]; response to cold [GO:0009409]; response to insulin [GO:0032868]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q60714}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q60714}. Endomembrane system {ECO:0000250|UniProtKB:Q60714}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q60714}. Cytoplasm {ECO:0000250|UniProtKB:Q60714}. Note=Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake. Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1. Predominantly cytoplasmic in myocytes. {ECO:0000250|UniProtKB:Q60714}.
Q6PCD5	reviewed	RFWD3_HUMAN	E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201)	RFWD3 RNF201	Homo sapiens (Human)	774	FUNCTION: E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658). Plays a key role in RPA-mediated DNA damage signaling and repair (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:28691929). Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination (PubMed:26474068, PubMed:28575657, PubMed:28575658). Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint (PubMed:20173098). May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:20173098). In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53 (PubMed:20173098). {ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:21558276, ECO:0000269|PubMed:26474068, ECO:0000269|PubMed:28575657, ECO:0000269|PubMed:28575658, ECO:0000269|PubMed:28691929}.		DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; replication fork processing [GO:0031297]; response to ionizing radiation [GO:0010212]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of DNA damage [GO:0090734]	MDM2/MDM4 family protein binding [GO:0097371]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of DNA damage [GO:0090734]; MDM2/MDM4 family protein binding [GO:0097371]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; ubiquitin protein ligase activity [GO:0061630]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; replication fork processing [GO:0031297]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:21558276, ECO:0000269|PubMed:28575657, ECO:0000269|PubMed:28691929}. Nucleus, PML body {ECO:0000269|PubMed:21558276}. Cytoplasm {ECO:0000269|PubMed:21558276, ECO:0000269|PubMed:28691929}. Note=In undamaged cells, found both in the cytoplasm and in the nucleus, partially associated with PML nuclear bodies (PubMed:21558276). In response to replication block, such as that caused by hydroxyurea treatment, or to DNA damage caused by ionizing radiations or doxorubicin, recruited to the nucleus, to stalled replication forks or to sites of DNA repair (PubMed:21504906, PubMed:28575657). This recruitment depends upon RPA2 (PubMed:21504906). {ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:28575657}.
Q6PCE3	reviewed	PGM2L_HUMAN	Glucose 1,6-bisphosphate synthase (EC 2.7.1.106) (PMMLP) (Phosphoglucomutase-2-like 1)	PGM2L1 BM32A	Homo sapiens (Human)	622	FUNCTION: Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate, as acceptors (PubMed:17804405). In vitro, also exhibits very low phosphopentomutase and phosphoglucomutase activity which are most probably not physiologically relevant (PubMed:17804405). {ECO:0000269|PubMed:17804405, ECO:0000269|PubMed:18927083, ECO:0000269|PubMed:33979636}.		glucose metabolic process [GO:0006006]	cytosol [GO:0005829]	glucose-1,6-bisphosphate synthase activity [GO:0047933]; intramolecular transferase activity, phosphotransferases [GO:0016868]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; glucose-1,6-bisphosphate synthase activity [GO:0047933]; intramolecular transferase activity, phosphotransferases [GO:0016868]; metal ion binding [GO:0046872]; glucose metabolic process [GO:0006006]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:17804405}.
Q6PCT2	reviewed	FXL19_HUMAN	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19)	FBXL19 FBL19	Homo sapiens (Human)	694	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization (PubMed:24684802, PubMed:29522376). Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner (PubMed:23871831). Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration (PubMed:24684802, PubMed:23512198). Mediates also ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis (By similarity). Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:29276034). Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation. In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q6PB97, ECO:0000269|PubMed:23512198, ECO:0000269|PubMed:23871831, ECO:0000269|PubMed:24684802, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:29522376}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	histone demethylase activity [GO:0032452]; transcription coregulator activity [GO:0003712]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; histone demethylase activity [GO:0032452]; transcription coregulator activity [GO:0003712]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23512198, ECO:0000269|PubMed:23871831, ECO:0000269|PubMed:29522376}. Nucleus {ECO:0000269|PubMed:29522376}.
Q6PD62	reviewed	CTR9_HUMAN	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1)	CTR9 KIAA0155 SH2BP1	Homo sapiens (Human)	1173	FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}.		blastocyst growth [GO:0001832]; blastocyst hatching [GO:0001835]; cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; inner cell mass cell differentiation [GO:0001826]; interleukin-6-mediated signaling pathway [GO:0070102]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; trophectodermal cell differentiation [GO:0001829]; Wnt signaling pathway [GO:0016055]	Cdc73/Paf1 complex [GO:0016593]; euchromatin [GO:0000791]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	RNA polymerase II complex binding [GO:0000993]; SH2 domain binding [GO:0042169]	Cdc73/Paf1 complex [GO:0016593]; euchromatin [GO:0000791]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; RNA polymerase II complex binding [GO:0000993]; SH2 domain binding [GO:0042169]; blastocyst growth [GO:0001832]; blastocyst hatching [GO:0001835]; cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; inner cell mass cell differentiation [GO:0001826]; interleukin-6-mediated signaling pathway [GO:0070102]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; trophectodermal cell differentiation [GO:0001829]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q62018}.
Q6PD74	reviewed	AAGAB_HUMAN	Alpha- and gamma-adaptin-binding protein p34	AAGAB	Homo sapiens (Human)	315	FUNCTION: May be involved in endocytic recycling of growth factor receptors such as EGFR. {ECO:0000269|PubMed:23064416}.		protein transport [GO:0015031]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23000146, ECO:0000269|PubMed:23064416}.
Q6PEW1	reviewed	ZCH12_HUMAN	Zinc finger CCHC domain-containing protein 12 (Smad-interacting zinc finger protein 1)	ZCCHC12 SIZN1	Homo sapiens (Human)	402	FUNCTION: Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity). {ECO:0000250}.			nucleus [GO:0005634]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	
Q6PEX3	reviewed	KR261_HUMAN	Keratin-associated protein 26-1	KRTAP26-1 KAP26.1	Homo sapiens (Human)	210	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; keratin filament [GO:0045095]; structural molecule activity [GO:0005198]	
Q6PEY1	reviewed	TMM88_HUMAN	Transmembrane protein 88	TMEM88 TMEM88A	Homo sapiens (Human)	159	FUNCTION: Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development. {ECO:0000269|PubMed:23924634}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	PDZ domain binding [GO:0030165]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; PDZ domain binding [GO:0030165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21044957}; Multi-pass membrane protein {ECO:0000269|PubMed:21044957}.
Q6PEY2	reviewed	TBA3E_HUMAN	Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain]	TUBA3E	Homo sapiens (Human)	450	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q6PF05	reviewed	TT23L_HUMAN	Tetratricopeptide repeat protein 23-like	TTC23L	Homo sapiens (Human)	361		MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	response to endoplasmic reticulum stress [GO:0034976]	cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; spindle [GO:0005819]		cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; spindle [GO:0005819]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25751302}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25751302}. Midbody {ECO:0000269|PubMed:25751302}. Note=Exhibits dynamic subcellular localization during the cell cycle. In prophase cells, detected on split centrosomes. Translocates to the mitotic spindles during metaphase and early anaphase, then to the midbody and cleavage furrow in late anaphase. {ECO:0000269|PubMed:25751302}.
Q6PF06	reviewed	TM10B_HUMAN	tRNA methyltransferase 10 homolog B (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 3) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10B)	TRMT10B RG9MTD3	Homo sapiens (Human)	316	FUNCTION: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). {ECO:0000269|PubMed:23042678}.		protein insertion into mitochondrial inner membrane [GO:0045039]; tRNA N1-guanine methylation [GO:0002939]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]	tRNA (guanine(9)-N(1))-methyltransferase activity [GO:0052905]; tRNA (guanine-N1-)-methyltransferase activity [GO:0009019]; tRNA binding [GO:0000049]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]; tRNA (guanine(9)-N(1))-methyltransferase activity [GO:0052905]; tRNA (guanine-N1-)-methyltransferase activity [GO:0009019]; tRNA binding [GO:0000049]; protein insertion into mitochondrial inner membrane [GO:0045039]; tRNA N1-guanine methylation [GO:0002939]	
Q6PF18	reviewed	MORN3_HUMAN	MORN repeat-containing protein 3	MORN3	Homo sapiens (Human)	240	FUNCTION: Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors (PubMed:29681526). May play a role in the regulation of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q8C5T4, ECO:0000269|PubMed:29681526}.			acrosomal vesicle [GO:0001669]; nucleus [GO:0005634]		acrosomal vesicle [GO:0001669]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8C5T4}. Note=Localized in the acrosome in germ cells throughout spermiogenesis, it is also present in the manchette of elongating spermatids. {ECO:0000250|UniProtKB:Q8C5T4}.
Q6PFW1	reviewed	VIP1_HUMAN	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1)	PPIP5K1 HISPPD2A IP6K IPS1 KIAA0377 VIP1	Homo sapiens (Human)	1433	FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}.		inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; phosphorylation [GO:0016310]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; diphosphoinositol-pentakisphosphate kinase activity [GO:0033857]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 3-kinase activity [GO:0052724]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; diphosphoinositol-pentakisphosphate kinase activity [GO:0033857]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 3-kinase activity [GO:0052724]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]; inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653}. Cell membrane {ECO:0000269|PubMed:21222653}. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway. {ECO:0000269|PubMed:21222653}.
Q6PGN9	reviewed	PSRC1_HUMAN	Proline/serine-rich coiled-coil protein 1	PSRC1 DDA3 FP3214	Homo sapiens (Human)	363	FUNCTION: Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}.		cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of cell growth [GO:0030308]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic spindle organization [GO:0060236]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; spindle pole [GO:0000922]	microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; spindle pole [GO:0000922]; microtubule binding [GO:0008017]; cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of cell growth [GO:0030308]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic spindle organization [GO:0060236]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.
Q6PGP7	reviewed	SKI3_HUMAN	Superkiller complex protein 3 (Ski3) (Tetratricopeptide repeat protein 37) (TPR repeat protein 37) (Tricho-hepatic-enteric syndrome protein) (Thespin)	SKIC3 KIAA0372 TTC37	Homo sapiens (Human)	1564	FUNCTION: Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656). {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:32006463, ECO:0000269|PubMed:35120588}.		nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; rescue of stalled ribosome [GO:0072344]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Ski complex [GO:0055087]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Ski complex [GO:0055087]; nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; rescue of stalled ribosome [GO:0072344]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16024656}. Nucleus {ECO:0000269|PubMed:16024656}.
Q6PGQ7	reviewed	BORA_HUMAN	Protein aurora borealis (HsBora)	BORA C13orf34	Homo sapiens (Human)	559	FUNCTION: Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}.		cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of mitotic nuclear division [GO:0007088]; regulation of mitotic spindle organization [GO:0060236]; regulation of protein localization [GO:0032880]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; nucleus [GO:0005634]	protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of mitotic nuclear division [GO:0007088]; regulation of mitotic spindle organization [GO:0060236]; regulation of protein localization [GO:0032880]	
Q6PH85	reviewed	DCNL2_HUMAN	DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2)	DCUN1D2 C13orf17 DCUN1L2	Homo sapiens (Human)	259	FUNCTION: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-box protein)-type complexes activity. {ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:26906416}.		positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182]; positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26906416}. Nucleus {ECO:0000269|PubMed:26906416}.
Q6PHR2	reviewed	ULK3_HUMAN	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3)	ULK3	Homo sapiens (Human)	472	FUNCTION: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to competing donor splice site. {ECO:0000305}.	autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular senescence [GO:0090398]; fibroblast activation [GO:0072537]; late nucleophagy [GO:0044805]; negative regulation of smoothened signaling pathway [GO:0045879]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of smoothened signaling pathway [GO:0045880]; protein autophosphorylation [GO:0046777]; regulation of autophagy [GO:0010506]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; smoothened signaling pathway [GO:0007224]	autophagosome [GO:0005776]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	autophagosome [GO:0005776]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular senescence [GO:0090398]; fibroblast activation [GO:0072537]; late nucleophagy [GO:0044805]; negative regulation of smoothened signaling pathway [GO:0045879]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of smoothened signaling pathway [GO:0045880]; protein autophosphorylation [GO:0046777]; regulation of autophagy [GO:0010506]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745}. Note=Localizes to pre-autophagosomal structure during cellular senescence.
Q6PHW0	reviewed	IYD1_HUMAN	Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)	IYD C6orf71 DEHAL1	Homo sapiens (Human)	289	FUNCTION: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:15289438, PubMed:18434651, PubMed:25395621, PubMed:28157283). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:18434651). The scavanged iodide can then reenter the hormone-producing pathways (PubMed:15289438, PubMed:18434651). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (PubMed:15289438). {ECO:0000269|PubMed:15289438, ECO:0000269|PubMed:18434651, ECO:0000269|PubMed:25395621, ECO:0000269|PubMed:28157283}.		thyroid hormone metabolic process [GO:0042403]; tyrosine metabolic process [GO:0006570]	cytoplasmic vesicle membrane [GO:0030659]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	FMN binding [GO:0010181]; iodotyrosine deiodinase activity [GO:0140616]; oxidoreductase activity [GO:0016491]	cytoplasmic vesicle membrane [GO:0030659]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; FMN binding [GO:0010181]; iodotyrosine deiodinase activity [GO:0140616]; oxidoreductase activity [GO:0016491]; thyroid hormone metabolic process [GO:0042403]; tyrosine metabolic process [GO:0006570]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15289438}; Single-pass membrane protein {ECO:0000269|PubMed:15289438}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:15289438}.
Q6PI25	reviewed	CNIH2_HUMAN	Protein cornichon homolog 2 (CNIH-2) (Cornichon family AMPA receptor auxiliary protein 2) (Cornichon-like protein)	CNIH2 CNIL	Homo sapiens (Human)	160	FUNCTION: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. {ECO:0000269|PubMed:20805473}.		regulation of AMPA receptor activity [GO:2000311]; vesicle-mediated transport [GO:0016192]	AMPA glutamate receptor complex [GO:0032281]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]		AMPA glutamate receptor complex [GO:0032281]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; regulation of AMPA receptor activity [GO:2000311]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Postsynaptic density {ECO:0000250}. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}.
Q6PI26	reviewed	SHQ1_HUMAN	Protein SHQ1 homolog	SHQ1	Homo sapiens (Human)	577	FUNCTION: Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. {ECO:0000269|PubMed:19383767, ECO:0000269|PubMed:34542157}.		box H/ACA snoRNP assembly [GO:0000493]; negative regulation of rRNA processing [GO:2000233]; positive regulation of apoptotic process [GO:0043065]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; protein-RNA complex assembly [GO:0022618]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; unfolded protein binding [GO:0051082]; box H/ACA snoRNP assembly [GO:0000493]; negative regulation of rRNA processing [GO:2000233]; positive regulation of apoptotic process [GO:0043065]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; protein-RNA complex assembly [GO:0022618]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19383767}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19383767}. Note=May at least partially shuttle between cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal bodies. Absent from most H/ACA-box RNA transcription sites.
Q6PI48	reviewed	SYDM_HUMAN	Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)	DARS2	Homo sapiens (Human)	645			aspartyl-tRNA aminoacylation [GO:0006422]; mitochondrial asparaginyl-tRNA aminoacylation [GO:0070145]; tRNA aminoacylation [GO:0043039]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	aspartate-tRNA ligase activity [GO:0004815]; aspartate-tRNA(Asn) ligase activity [GO:0050560]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; aspartate-tRNA ligase activity [GO:0004815]; aspartate-tRNA(Asn) ligase activity [GO:0050560]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; aspartyl-tRNA aminoacylation [GO:0006422]; mitochondrial asparaginyl-tRNA aminoacylation [GO:0070145]; tRNA aminoacylation [GO:0043039]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:15779907}.
Q6PI77	reviewed	GASP3_HUMAN	G protein-coupled receptor associated sorting protein 3 (Protein BHLHb9) (bHLHb9) (Transcription regulator of 60 kDa) (p60TRP)	GPRASP3 BHLHB9 KIAA1701	Homo sapiens (Human)	547	FUNCTION: Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis. Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1-mediated processing of APP. {ECO:0000250|UniProtKB:Q6PB60}.		learning or memory [GO:0007611]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of neurogenesis [GO:0050769]; positive regulation of synapse assembly [GO:0051965]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; protein homodimerization activity [GO:0042803]; learning or memory [GO:0007611]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of neurogenesis [GO:0050769]; positive regulation of synapse assembly [GO:0051965]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15034937}. Nucleus {ECO:0000269|PubMed:15034937}. Note=Mainly cytoplasmic, and nuclear at lower level.
Q6PI78	reviewed	TMM65_HUMAN	Transmembrane protein 65	TMEM65	Homo sapiens (Human)	240	FUNCTION: May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance (PubMed:28295037). {ECO:0000250|UniProtKB:Q4VAE3, ECO:0000269|PubMed:28295037}.		cardiac ventricle development [GO:0003231]; regulation of cardiac conduction [GO:1903779]	intercalated disc [GO:0014704]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]		intercalated disc [GO:0014704]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; cardiac ventricle development [GO:0003231]; regulation of cardiac conduction [GO:1903779]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26403541}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:24765583, ECO:0000269|PubMed:28295037}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes at the intercalated disk in the ventricular tissue (PubMed:26403541). {ECO:0000269|PubMed:26403541}.
Q6PI98	reviewed	IN80C_HUMAN	INO80 complex subunit C (IES6 homolog) (hIes6)	INO80C C18orf37	Homo sapiens (Human)	192	FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.		chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	Ino80 complex [GO:0031011]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]		Ino80 complex [GO:0031011]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18922472}.
Q6PID8	reviewed	KLD10_HUMAN	Kelch domain-containing protein 10	KLHDC10 KIAA0265	Homo sapiens (Human)	442	FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33909987). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:33909987). The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) or an alanine tail (CAT tail) at the C-terminus, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33909987). The CRL2(KLHDC10) complex is involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: CRL2(KLHDC10) acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (PubMed:33909987). Participates in the oxidative stress-induced cell death through MAP3K5 activation (PubMed:23102700). Inhibits PPP5C phosphatase activity on MAP3K5 (PubMed:23102700). Acts as a regulator of necroptosis (By similarity). {ECO:0000250|UniProtKB:Q6PAR0, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:33909987}.		positive regulation of stress-activated MAPK cascade [GO:0032874]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23102700}. Cytoplasm {ECO:0000269|PubMed:23102700}.
Q6PIF2	reviewed	SYCE2_HUMAN	Synaptonemal complex central element protein 2 (Central element synaptonemal complex protein 1)	SYCE2 CESC1	Homo sapiens (Human)	218	FUNCTION: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity). {ECO:0000250|UniProtKB:Q505B8}.		cell division [GO:0051301]; synaptonemal complex assembly [GO:0007130]	central element [GO:0000801]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]		central element [GO:0000801]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; cell division [GO:0051301]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q505B8}. Chromosome {ECO:0000250|UniProtKB:Q505B8}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE1 in the central elements (By similarity). {ECO:0000250|UniProtKB:Q505B8}.
Q6PIF6	reviewed	MYO7B_HUMAN	Unconventional myosin-VIIb	MYO7B	Homo sapiens (Human)	2116	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable). {ECO:0000305|PubMed:24725409, ECO:0000305|PubMed:26812018}.		actin filament organization [GO:0007015]; brush border assembly [GO:1904970]; cell differentiation [GO:0030154]; sensory organ development [GO:0007423]; sensory perception of sound [GO:0007605]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; apical cytoplasm [GO:0090651]; brush border [GO:0005903]; cytoplasm [GO:0005737]; microvillus [GO:0005902]; myosin complex [GO:0016459]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]	actin cytoskeleton [GO:0015629]; apical cytoplasm [GO:0090651]; brush border [GO:0005903]; cytoplasm [GO:0005737]; microvillus [GO:0005902]; myosin complex [GO:0016459]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; actin filament organization [GO:0007015]; brush border assembly [GO:1904970]; cell differentiation [GO:0030154]; sensory organ development [GO:0007423]; sensory perception of sound [GO:0007605]; vesicle transport along actin filament [GO:0030050]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, microvillus {ECO:0000269|PubMed:24725409}. Note=Enriched in the microvilli of the intestinal brush border. {ECO:0000269|PubMed:24725409}.
Q6PIJ6	reviewed	FBX38_HUMAN	F-box only protein 38	FBXO38 SP329	Homo sapiens (Human)	1188	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}.		adaptive immune response [GO:0002250]; positive regulation of neuron projection development [GO:0010976]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; protein K48-linked ubiquitination [GO:0070936]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; adaptive immune response [GO:0002250]; positive regulation of neuron projection development [GO:0010976]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; protein K48-linked ubiquitination [GO:0070936]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8BMI0}. Nucleus {ECO:0000250|UniProtKB:Q8BMI0}. Note=Accumulates predominantly in the cytosol. Exported from the nucleus in a XPO1/CRM1-dependent manner. {ECO:0000250|UniProtKB:Q8BMI0}.
Q6PIL6	reviewed	KCIP4_HUMAN	Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4)	KCNIP4 CALP KCHIP4	Homo sapiens (Human)	250	FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane. {ECO:0000250|UniProtKB:Q6PHZ8, ECO:0000269|PubMed:11847232, ECO:0000269|PubMed:18957440, ECO:0000269|PubMed:23576435}.		protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transmembrane transport [GO:1901379]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	calcium ion binding [GO:0005509]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; voltage-gated monoatomic ion channel activity [GO:0005244]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; calcium ion binding [GO:0005509]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; voltage-gated monoatomic ion channel activity [GO:0005244]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transmembrane transport [GO:1901379]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11847232}; Peripheral membrane protein {ECO:0000305|PubMed:11847232}. Cytoplasm {ECO:0000269|PubMed:11847232, ECO:0000269|PubMed:23576435}. Peroxisome {ECO:0000269|PubMed:22057399}.; SUBCELLULAR LOCATION: [Isoform 4]: Endoplasmic reticulum {ECO:0000269|PubMed:23576435}.
Q6PIU1	reviewed	KCNV1_HUMAN	Potassium voltage-gated channel subfamily V member 1 (Neuronal potassium channel alpha subunit HNKA) (Voltage-gated potassium channel subunit Kv8.1)	KCNV1	Homo sapiens (Human)	500	FUNCTION: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. {ECO:0000269|PubMed:8670833, ECO:0000269|PubMed:9079713}.		potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	intercellular bridge [GO:0045171]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	ion channel inhibitor activity [GO:0008200]; potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249]	intercellular bridge [GO:0045171]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; ion channel inhibitor activity [GO:0008200]; potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8670833, ECO:0000269|PubMed:9079713}; Multi-pass membrane protein {ECO:0000269|PubMed:8670833, ECO:0000269|PubMed:9079713}. Note=Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2.
Q6PIU2	reviewed	NCEH1_HUMAN	Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1)	NCEH1 AADACL1 KIAA1363	Homo sapiens (Human)	408	FUNCTION: Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:17052608). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). May contribute to cancer pathogenesis by promoting tumor cell migration (PubMed:17052608). {ECO:0000250|UniProtKB:Q8BLF1, ECO:0000269|PubMed:17052608}.		ether lipid metabolic process [GO:0046485]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle clearance [GO:0034383]; SMAD protein signal transduction [GO:0060395]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	acetylalkylglycerol acetylhydrolase activity [GO:0047378]; phosphate ion binding [GO:0042301]; serine hydrolase activity [GO:0017171]; sterol esterase activity [GO:0004771]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; acetylalkylglycerol acetylhydrolase activity [GO:0047378]; phosphate ion binding [GO:0042301]; serine hydrolase activity [GO:0017171]; sterol esterase activity [GO:0004771]; ether lipid metabolic process [GO:0046485]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle clearance [GO:0034383]; SMAD protein signal transduction [GO:0060395]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17052608, ECO:0000305|PubMed:12149457}; Single-pass type II membrane protein {ECO:0000305|PubMed:12149457}. Microsome {ECO:0000250|UniProtKB:Q8BLF1}.
Q6PIV2	reviewed	FOXR1_HUMAN	Forkhead box protein R1 (Forkhead box protein N5)	FOXR1 FOXN5 DLNB13	Homo sapiens (Human)	292	FUNCTION: Transcription factor which acts as both an activator and a repressor (PubMed:34723967). Activates transcription of a number of genes including the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 which are involved in protection against oxidative stress (PubMed:34723967). Required for normal brain development (By similarity). {ECO:0000250|UniProtKB:Q3UTB7, ECO:0000269|PubMed:34723967}.		brain development [GO:0007420]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific double-stranded DNA binding [GO:1990837]; brain development [GO:0007420]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34723967}. Cytoplasm {ECO:0000269|PubMed:25609838, ECO:0000269|PubMed:34723967}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:25609838}. Note=Localizes to the nucleus and cytoplasm with higher levels in the nucleus where it is expressed in a diffuse manner (PubMed:34723967). Located in the cytoplasm of spermatocytes and strongly accumulates at the perinuclear region in elongated spermatids (PubMed:25609838). {ECO:0000269|PubMed:25609838, ECO:0000269|PubMed:34723967}.
Q6PIW4	reviewed	FIGL1_HUMAN	Fidgetin-like protein 1 (EC 3.6.4.-)	FIGNL1	Homo sapiens (Human)	674	FUNCTION: Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity). {ECO:0000250|UniProtKB:Q8BPY9, ECO:0000269|PubMed:23754376}.		ATP metabolic process [GO:0046034]; cellular response to ionizing radiation [GO:0071479]; male meiotic nuclear division [GO:0007140]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair via homologous recombination [GO:0010569]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; microtubule severing ATPase activity [GO:0008568]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; microtubule severing ATPase activity [GO:0008568]; ATP metabolic process [GO:0046034]; cellular response to ionizing radiation [GO:0071479]; male meiotic nuclear division [GO:0007140]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair via homologous recombination [GO:0010569]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23754376}. Cytoplasm {ECO:0000250|UniProtKB:Q8BPY9}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8BPY9}. Note=Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment (PubMed:23754376).
Q6PIY7	reviewed	GLD2_HUMAN	Poly(A) RNA polymerase GLD2 (hGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Terminal uridylyltransferase 2) (TUTase 2)	TENT2 GLD2 PAPD4	Homo sapiens (Human)	484	FUNCTION: Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail (PubMed:15070731, PubMed:31792053). In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856, PubMed:31792053). {ECO:0000269|PubMed:15070731, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:23200856, ECO:0000269|PubMed:31792053}.		hematopoietic progenitor cell differentiation [GO:0002244]; histone mRNA catabolic process [GO:0071044]; mRNA polyadenylation [GO:0006378]; negative regulation of miRNA catabolic process [GO:2000626]	cytoplasm [GO:0005737]; nuclear RNA-directed RNA polymerase complex [GO:0031380]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]	cytoplasm [GO:0005737]; nuclear RNA-directed RNA polymerase complex [GO:0031380]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; hematopoietic progenitor cell differentiation [GO:0002244]; histone mRNA catabolic process [GO:0071044]; mRNA polyadenylation [GO:0006378]; negative regulation of miRNA catabolic process [GO:2000626]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q91YI6}. Nucleus {ECO:0000250|UniProtKB:Q91YI6}.
Q6PIZ9	reviewed	TRAT1_HUMAN	T-cell receptor-associated transmembrane adapter 1 (T-cell receptor-interacting molecule) (TRIM) (pp29/30)	TRAT1 TCRIM HSPC062	Homo sapiens (Human)	186	FUNCTION: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. {ECO:0000269|PubMed:11390434}.		adaptive immune response [GO:0002250]; cellular defense response [GO:0006968]; negative regulation of receptor recycling [GO:0001920]; negative regulation of transport [GO:0051051]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of T cell receptor signaling pathway [GO:0050862]; signal transduction [GO:0007165]	centriolar satellite [GO:0034451]; mitotic spindle [GO:0072686]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	centriolar satellite [GO:0034451]; mitotic spindle [GO:0072686]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; adaptive immune response [GO:0002250]; cellular defense response [GO:0006968]; negative regulation of receptor recycling [GO:0001920]; negative regulation of transport [GO:0051051]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of T cell receptor signaling pathway [GO:0050862]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9687533}; Single-pass type III membrane protein {ECO:0000269|PubMed:9687533}.
Q6PJ69	reviewed	TRI65_HUMAN	E3 ubiquitin-protein ligase TRIM65 (EC 2.3.2.27) (Tripartite motif-containing protein 65)	TRIM65	Homo sapiens (Human)	517	FUNCTION: E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:28594402, PubMed:34512673). Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein involved in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (PubMed:24778252). This ubiquitination results in the suppressed expression of miR-138-5p leading to increased autophagy (PubMed:31160576). Upon enteroviral infection, promotes 'Lys-63'-mediated ubiquitination activation of IFIH1/MDA5 leading to innate signaling cascade (PubMed:28594402). Mechanistically, selectively recognizes MDA5 filaments that occur on dsRNAs (PubMed:33373584). Plays also a role in limitation of inflammation through different mechanisms. First, promotes 'Lys-48'-mediated ubiquitination of VCAM1 leading to its degradation and limitation of LPS-induced lung inflammation (PubMed:31310649). In addition, negatively regulates inflammasome activation by promoting 'lys48'-linked ubiquitination of NLRP3 which is critical for the inhibition of NLRP3 inflammasome activation in resting macrophages (PubMed:34512673). {ECO:0000269|PubMed:24778252, ECO:0000269|PubMed:28594402, ECO:0000269|PubMed:31160576, ECO:0000269|PubMed:31310649, ECO:0000269|PubMed:33373584, ECO:0000269|PubMed:34512673}.		antiviral innate immune response [GO:0140374]; negative regulation of inflammatory response [GO:0050728]; positive regulation of autophagy [GO:0010508]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of protein oligomerization [GO:0032461]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; type I interferon-mediated signaling pathway [GO:0060337]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; antiviral innate immune response [GO:0140374]; negative regulation of inflammatory response [GO:0050728]; positive regulation of autophagy [GO:0010508]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of protein oligomerization [GO:0032461]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24778252, ECO:0000269|PubMed:34512673}.
Q6PJF5	reviewed	RHDF2_HUMAN	Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6)	RHBDF2 IRHOM2 RHBDL5 RHBDL6	Homo sapiens (Human)	856	FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}.		negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of protein secretion [GO:0050709]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of protein secretion [GO:0050708]	endoplasmic reticulum membrane [GO:0005789]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	growth factor binding [GO:0019838]; protein transporter activity [GO:0140318]	endoplasmic reticulum membrane [GO:0005789]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; growth factor binding [GO:0019838]; protein transporter activity [GO:0140318]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of protein secretion [GO:0050709]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of protein secretion [GO:0050708]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q80WQ6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80WQ6}. Cell membrane {ECO:0000269|PubMed:22265016, ECO:0000269|PubMed:29897333}.
Q6PJG6	reviewed	BRAT1_HUMAN	BRCA1-associated ATM activator 1 (BRCA1-associated protein required for ATM activation protein 1)	BRAT1 BAAT1 C7orf27	Homo sapiens (Human)	821	FUNCTION: Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994}.		apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; glucose metabolic process [GO:0006006]; mitochondrion localization [GO:0051646]; positive regulation of cell growth [GO:0030307]; positive regulation of protein phosphorylation [GO:0001934]; response to ionizing radiation [GO:0010212]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; glucose metabolic process [GO:0006006]; mitochondrion localization [GO:0051646]; positive regulation of cell growth [GO:0030307]; positive regulation of protein phosphorylation [GO:0001934]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:25631046}. Cytoplasm {ECO:0000269|PubMed:25631046}. Note=Present at double strand breaks (DSBs)following ionizing radiation treatment. The ubiquitinated form localizes in the nucleus in a NDFIP1-dependent manner. {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:25631046}.
Q6PJG9	reviewed	LRFN4_HUMAN	Leucine-rich repeat and fibronectin type-III domain-containing protein 4	LRFN4 SALM3	Homo sapiens (Human)	635	FUNCTION: Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). {ECO:0000250}.		regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]	cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]		cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q6PJI9	reviewed	WDR59_HUMAN	GATOR2 complex protein WDR59 (WD repeat-containing protein 59)	WDR59 KIAA1923 FP977	Homo sapiens (Human)	974	FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:25457612, PubMed:23723238, PubMed:27487210, PubMed:36528027, PubMed:36577058, PubMed:35831510). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:36528027, PubMed:35831510). GATOR2 probably acts as a E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:27487210). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027, ECO:0000269|PubMed:36577058}.		cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]	cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; Seh1-associated complex [GO:0035859]; vacuolar membrane [GO:0005774]	signaling adaptor activity [GO:0035591]	cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; Seh1-associated complex [GO:0035859]; vacuolar membrane [GO:0005774]; signaling adaptor activity [GO:0035591]; cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28199306}.
Q6PJP8	reviewed	DCR1A_HUMAN	DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A)	DCLRE1A KIAA0086 SNM1 SNM1A	Homo sapiens (Human)	1040	FUNCTION: May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). {ECO:0000269|PubMed:15542852}.		cell cycle [GO:0007049]; cell division [GO:0051301]; double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297]	fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]	5'-3' DNA exonuclease activity [GO:0035312]; beta-lactamase activity [GO:0008800]; damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]	fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; 5'-3' DNA exonuclease activity [GO:0035312]; beta-lactamase activity [GO:0008800]; damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]; cell cycle [GO:0007049]; cell division [GO:0051301]; double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10848582, ECO:0000269|PubMed:12446782, ECO:0000269|PubMed:15572677}. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1.
Q6PJT7	reviewed	ZC3HE_HUMAN	Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37)	ZC3H14	Homo sapiens (Human)	736	FUNCTION: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides. {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764}.	MISCELLANEOUS: ZC3H14 can functionally substitute for Nab2 in fly neurons and can rescue defects in development and locomotion that are present in dNab2 null flies.	negative regulation of mRNA polyadenylation [GO:1900364]; regulation of mRNA stability [GO:0043488]	axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; dendrite cytoplasm [GO:0032839]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	metal ion binding [GO:0046872]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]	axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; dendrite cytoplasm [GO:0032839]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; metal ion binding [GO:0046872]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; negative regulation of mRNA polyadenylation [GO:1900364]; regulation of mRNA stability [GO:0043488]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:19303045, ECO:0000269|PubMed:24671764}. Note=Colocalizes with poly(A) RNA in nuclear speckles. {ECO:0000250|UniProtKB:Q7TMD5}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus speckle.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus speckle.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000269|PubMed:21734151}.
Q6PJW8	reviewed	CNST_HUMAN	Consortin	CNST C1orf71	Homo sapiens (Human)	725	FUNCTION: Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}.		positive regulation of Golgi to plasma membrane protein transport [GO:0042998]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]	connexin binding [GO:0071253]; phosphatase binding [GO:0019902]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]; connexin binding [GO:0071253]; phosphatase binding [GO:0019902]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19864490}; Single-pass membrane protein {ECO:0000269|PubMed:19864490}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19864490}; Single-pass membrane protein {ECO:0000269|PubMed:19864490}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:19864490}. Note=Located predominantly in the trans-Golgi network. Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway.
Q6PKC3	reviewed	TXD11_HUMAN	Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1)	TXNDC11 EFP1	Homo sapiens (Human)	985	FUNCTION: May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.			endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6PKG0	reviewed	LARP1_HUMAN	La-related protein 1 (La ribonucleoprotein domain family member 1)	LARP1 KIAA0731 LARP	Homo sapiens (Human)	1096	FUNCTION: RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}.		cell population proliferation [GO:0008283]; cellular response to rapamycin [GO:0072752]; mRNA stabilization [GO:0048255]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; positive regulation of macroautophagy [GO:0016239]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; positive regulation of viral genome replication [GO:0045070]; post-transcriptional regulation of gene expression [GO:0010608]; response to amino acid starvation [GO:1990928]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]	cadherin binding [GO:0045296]; eukaryotic initiation factor 4E binding [GO:0008190]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; ribosomal small subunit binding [GO:0043024]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation activator activity [GO:0008494]; translation initiation factor binding [GO:0031369]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; cadherin binding [GO:0045296]; eukaryotic initiation factor 4E binding [GO:0008190]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; ribosomal small subunit binding [GO:0043024]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation activator activity [GO:0008494]; translation initiation factor binding [GO:0031369]; cell population proliferation [GO:0008283]; cellular response to rapamycin [GO:0072752]; mRNA stabilization [GO:0048255]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; positive regulation of macroautophagy [GO:0016239]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; positive regulation of viral genome replication [GO:0045070]; post-transcriptional regulation of gene expression [GO:0010608]; response to amino acid starvation [GO:1990928]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:28650797}. Cytoplasmic granule {ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091}. Note=Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules. {ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091}.
Q6PKX4	reviewed	DOK6_HUMAN	Docking protein 6 (Downstream of tyrosine kinase 6)	DOK6 DOK5L	Homo sapiens (Human)	331	FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. {ECO:0000269|PubMed:15286081}.		positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; cytosol [GO:0005829]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	
Q6PL18	reviewed	ATAD2_HUMAN	ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA)	ATAD2 L16 PRO2000	Homo sapiens (Human)	1390	FUNCTION: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}.	MISCELLANEOUS: [Isoform 2]: Dubious isoform. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; histone binding [GO:0042393]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17998543, ECO:0000269|PubMed:25593309}.
Q6PL24	reviewed	TMED8_HUMAN	Protein TMED8	TMED8 FAM15B L10	Homo sapiens (Human)	325							
Q6PL45	reviewed	BRID5_HUMAN	BRICHOS domain-containing protein 5	BRICD5 C16orf79	Homo sapiens (Human)	260			regulation of cell population proliferation [GO:0042127]	extracellular space [GO:0005615]; membrane [GO:0016020]		extracellular space [GO:0005615]; membrane [GO:0016020]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6PML9	reviewed	ZNT9_HUMAN	Proton-coupled zinc antiporter SLC30A9, mitochondrial (Human embryonic lung protein) (HuEL) (Solute carrier family 30 member 9) (Zinc transporter 9) (ZnT-9)	SLC30A9 C4orf1 HUEL	Homo sapiens (Human)	568	FUNCTION: Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health (PubMed:28334855, PubMed:34397090, PubMed:35614220, PubMed:34433664). In nucleus, functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (By similarity). {ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000269|PubMed:28334855, ECO:0000269|PubMed:34397090, ECO:0000269|PubMed:34433664, ECO:0000269|PubMed:35614220}.		intracellular zinc ion homeostasis [GO:0006882]; nucleotide-excision repair [GO:0006289]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitochondrion organization [GO:0010821]; zinc ion transport [GO:0006829]	cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]	antiporter activity [GO:0015297]; chromatin binding [GO:0003682]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; zinc ion transmembrane transporter activity [GO:0005385]	cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; antiporter activity [GO:0015297]; chromatin binding [GO:0003682]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; zinc ion transmembrane transporter activity [GO:0005385]; intracellular zinc ion homeostasis [GO:0006882]; nucleotide-excision repair [GO:0006289]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitochondrion organization [GO:0010821]; zinc ion transport [GO:0006829]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:34397090, ECO:0000269|PubMed:35614220}; Multi-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:10409434}. Endoplasmic reticulum {ECO:0000269|PubMed:28334855}. Note=Partial co-localization with endoplasmic reticulum (PubMed:28334855). Linked to mitochondrial ribosomes (PubMed:35614220). {ECO:0000269|PubMed:10409434, ECO:0000269|PubMed:28334855, ECO:0000269|PubMed:35614220}.
Q6PRD1	reviewed	GP179_HUMAN	Probable G-protein coupled receptor 179 (Probable G-protein coupled receptor 158-like 1) (GPR158-like)	GPR179 GPR158L GPR158L1	Homo sapiens (Human)	2367	FUNCTION: Orphan receptor involved in vision (PubMed:24084093, PubMed:22325362). Required for signal transduction through retinal depolarizing bipolar cells (PubMed:22325362). Acts as an atypical G-protein coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1 (By similarity). {ECO:0000250|UniProtKB:E9PY61, ECO:0000269|PubMed:22325362, ECO:0000269|PubMed:24084093}.		visual perception [GO:0007601]	dendrite [GO:0030425]; postsynaptic membrane [GO:0045211]	G protein-coupled receptor activity [GO:0004930]	dendrite [GO:0030425]; postsynaptic membrane [GO:0045211]; G protein-coupled receptor activity [GO:0004930]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E9PY61}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:E9PY61}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:24084093}. Note=Specifically localizes to the tips of retinal ON-bipolar dendrites. {ECO:0000269|PubMed:24084093}.
Q6PRD7	reviewed	CEMP1_HUMAN	Cementoblastoma-derived protein 1 (Cementum protein 1) (Cementum protein 23) (CP-23)	CEMP1	Homo sapiens (Human)	247	FUNCTION: May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum (PubMed:21929512, PubMed:17509525, PubMed:21465469). Binds hydroxyapatite and may promote the biomineralization of the cementum (PubMed:19393626). Also promotes cell proliferation (PubMed:17509525, PubMed:21929512, PubMed:26011628). {ECO:0000269|PubMed:17509525, ECO:0000269|PubMed:19393626, ECO:0000269|PubMed:21465469, ECO:0000269|PubMed:21929512, ECO:0000269|PubMed:26011628}.		biomineral tissue development [GO:0031214]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; odontogenesis [GO:0042476]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	hydroxyapatite binding [GO:0046848]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; hydroxyapatite binding [GO:0046848]; biomineral tissue development [GO:0031214]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; odontogenesis [GO:0042476]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16263347, ECO:0000269|PubMed:21465469}. Nucleus {ECO:0000269|PubMed:21465469}. Note=Localizes to the nucleus of some cementoblasts. {ECO:0000269|PubMed:21465469}.
Q6PUV4	reviewed	CPLX2_HUMAN	Complexin-2 (Complexin II) (CPX II) (Synaphin-1)	CPLX2	Homo sapiens (Human)	134	FUNCTION: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity). {ECO:0000250|UniProtKB:P84086, ECO:0000250|UniProtKB:P84088}.		cell differentiation [GO:0030154]; mast cell degranulation [GO:0043303]; nervous system development [GO:0007399]; positive regulation of synaptic plasticity [GO:0031915]; regulation of exocytosis [GO:0017157]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; synaptic vesicle exocytosis [GO:0016079]; vesicle docking involved in exocytosis [GO:0006904]	calyx of Held [GO:0044305]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; SNARE complex [GO:0031201]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [GO:0070033]; synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex [GO:0070554]; terminal bouton [GO:0043195]	calcium-dependent protein binding [GO:0048306]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]	calyx of Held [GO:0044305]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; SNARE complex [GO:0031201]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [GO:0070033]; synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex [GO:0070554]; terminal bouton [GO:0043195]; calcium-dependent protein binding [GO:0048306]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]; cell differentiation [GO:0030154]; mast cell degranulation [GO:0043303]; nervous system development [GO:0007399]; positive regulation of synaptic plasticity [GO:0031915]; regulation of exocytosis [GO:0017157]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; synaptic vesicle exocytosis [GO:0016079]; vesicle docking involved in exocytosis [GO:0006904]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P84087}. Presynapse {ECO:0000250|UniProtKB:P84087}. Nucleus {ECO:0000250|UniProtKB:P84087}. Perikaryon {ECO:0000250|UniProtKB:P84087}. Note=Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation. {ECO:0000250|UniProtKB:P84087}.
Q6PXP3	reviewed	GTR7_HUMAN	Solute carrier family 2, facilitated glucose transporter member 7 (Glucose transporter type 7) (GLUT-7) (hGLUT7)	SLC2A7 GLUT7	Homo sapiens (Human)	512	FUNCTION: Probable sugar transporter (PubMed:28083649). Even if its physiological substrate is subject to discussion, it is able to transport glucose and fructose (PubMed:29548810, PubMed:28083649, PubMed:16186102). Does not transport galactose, 2-deoxy-d-glucose and xylose (PubMed:15033637). {ECO:0000269|PubMed:15033637, ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:29548810}.		fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; monosaccharide transmembrane transport [GO:0015749]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]	D-glucose transmembrane transporter activity [GO:0055056]; fructose transmembrane transporter activity [GO:0005353]; hexose transmembrane transporter activity [GO:0015149]; sugar transmembrane transporter activity [GO:0051119]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]; D-glucose transmembrane transporter activity [GO:0055056]; fructose transmembrane transporter activity [GO:0005353]; hexose transmembrane transporter activity [GO:0015149]; sugar transmembrane transporter activity [GO:0051119]; fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; monosaccharide transmembrane transport [GO:0015749]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:28083649}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:29548810}; Multi-pass membrane protein {ECO:0000255}.
Q6Q0C0	reviewed	TRAF7_HUMAN	E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)	TRAF7 RFWD1 RNF119	Homo sapiens (Human)	670	FUNCTION: E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis (PubMed:15001576, PubMed:37086853). Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (By similarity). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response (PubMed:37086853). Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B (PubMed:21518757). {ECO:0000250|UniProtKB:Q922B6, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15001576, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:29961569, ECO:0000269|PubMed:37086853}.		apoptotic process [GO:0006915]; Notch signaling pathway [GO:0007219]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein ubiquitination [GO:0016567]; regulation of ERK1 and ERK2 cascade [GO:0070372]; ribosomal large subunit assembly [GO:0000027]	cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; Notch signaling pathway [GO:0007219]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein ubiquitination [GO:0016567]; regulation of ERK1 and ERK2 cascade [GO:0070372]; ribosomal large subunit assembly [GO:0000027]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:14743216}. Cytoplasm {ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:37086853}. Nucleus {ECO:0000269|PubMed:37086853}. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
Q6Q0C1	reviewed	S2547_HUMAN	Solute carrier family 25 member 47 (Hepatocellular carcinoma down-regulated mitochondrial carrier protein) (Mitochondrial NAD(+) transporter SLC25A47)	SLC25A47 C14orf68 HDMCP HMFN1655	Homo sapiens (Human)	308	FUNCTION: Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q6IS41, ECO:0000269|PubMed:36804859}.			mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	acetyl-CoA transmembrane transporter activity [GO:0008521]; NAD transmembrane transporter activity [GO:0051724]; transmembrane transporter activity [GO:0022857]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; acetyl-CoA transmembrane transporter activity [GO:0008521]; NAD transmembrane transporter activity [GO:0051724]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:15322095}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q6IS41}; Multi-pass membrane protein {ECO:0000255}.
Q6Q4G3	reviewed	AMPQ_HUMAN	Aminopeptidase Q (AP-Q) (APQ) (EC 3.4.11.-) (CHL2 antigen) (Laeverin)	LVRN AQPEP	Homo sapiens (Human)	990	FUNCTION: Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C. {ECO:0000269|PubMed:17525158}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; membrane [GO:0016020]	metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; membrane [GO:0016020]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000303|PubMed:17525158}; Single-pass type II membrane protein {ECO:0000303|PubMed:17525158}.
Q6Q759	reviewed	SPG17_HUMAN	Sperm-associated antigen 17 (Projection protein PF6 homolog)	SPAG17	Homo sapiens (Human)	2223	FUNCTION: Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts (By similarity). Essential for normal spermatogenesis and male fertility (By similarity). Required for normal manchette structure, transport of proteins along the manchette microtubules and formation of the sperm head and flagellum (By similarity). Essential for sperm flagellum development and proper assembly of the respiratory motile cilia central pair apparatus, but not the brain ependymal cilia (By similarity). {ECO:0000250|UniProtKB:Q5S003}.		axonemal central apparatus assembly [GO:1904158]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; intramanchette transport [GO:1990953]; manchette assembly [GO:1905198]; motile cilium assembly [GO:0044458]; spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]; axonemal central apparatus [GO:1990716]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; manchette [GO:0002177]; microtubule [GO:0005874]; motile cilium [GO:0031514]		acrosomal vesicle [GO:0001669]; axonemal central apparatus [GO:1990716]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; manchette [GO:0002177]; microtubule [GO:0005874]; motile cilium [GO:0031514]; axonemal central apparatus assembly [GO:1904158]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; intramanchette transport [GO:1990953]; manchette assembly [GO:1905198]; motile cilium assembly [GO:0044458]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5S003}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q5S003}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q5S003}. Golgi apparatus {ECO:0000250|UniProtKB:Q5S003}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5S003}. Note=Detected in the cytoplasm of round spermatids and in condensing spermatids. Localized to the central pair of the sperm flagellar axoneme. Colocalizes with SPAG6 on microtubules (By similarity). Localizes to the manchette in elongating spermatids (By similarity). {ECO:0000250|UniProtKB:Q5S003}.
Q6Q788	reviewed	APOA5_HUMAN	Apolipoprotein A-V (Apo-AV) (ApoA-V) (Apolipoprotein A5) (Regeneration-associated protein 3)	APOA5 RAP3 UNQ411/PRO773	Homo sapiens (Human)	366	FUNCTION: Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin (PubMed:17326667). {ECO:0000250|UniProtKB:Q8C7G5, ECO:0000269|PubMed:11588264, ECO:0000269|PubMed:12899628, ECO:0000269|PubMed:15528295, ECO:0000269|PubMed:17326667}.	MISCELLANEOUS: Induced in early phase of liver regeneration.	acylglycerol homeostasis [GO:0055090]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; phospholipid efflux [GO:0033700]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of triglyceride catabolic process [GO:0010898]; positive regulation of very-low-density lipoprotein particle remodeling [GO:0010902]; tissue regeneration [GO:0042246]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle remodeling [GO:0034372]	chylomicron [GO:0042627]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; high-density lipoprotein particle [GO:0034364]; late endosome [GO:0005770]; very-low-density lipoprotein particle [GO:0034361]	enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; heparin binding [GO:0008201]; lipase activator activity [GO:0060229]; lipase binding [GO:0035473]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; lipoprotein particle receptor binding [GO:0070325]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]	chylomicron [GO:0042627]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; high-density lipoprotein particle [GO:0034364]; late endosome [GO:0005770]; very-low-density lipoprotein particle [GO:0034361]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; heparin binding [GO:0008201]; lipase activator activity [GO:0060229]; lipase binding [GO:0035473]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; lipoprotein particle receptor binding [GO:0070325]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; acylglycerol homeostasis [GO:0055090]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; phospholipid efflux [GO:0033700]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of triglyceride catabolic process [GO:0010898]; positive regulation of very-low-density lipoprotein particle remodeling [GO:0010902]; tissue regeneration [GO:0042246]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle remodeling [GO:0034372]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12810715}. Early endosome {ECO:0000269|PubMed:18603531}. Late endosome {ECO:0000269|PubMed:18603531}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:18603531}. Note=In the presence of SORL1, internalized to early endosomes, sorted in a retrograde fashion to late endosomes, from which a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network. {ECO:0000269|PubMed:18603531}.
Q6QHC5	reviewed	DEGS2_HUMAN	Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 (EC 1.14.18.5) (EC 1.14.19.17) (Degenerative spermatocyte homolog 2) (Sphingolipid 4-desaturase) (Sphingolipid C4-monooxygenase)	DEGS2 C14orf66	Homo sapiens (Human)	323	FUNCTION: Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. {ECO:0000269|PubMed:15063729}.		ceramide biosynthetic process [GO:0046513]; sphinganine metabolic process [GO:0006667]; sphingolipid biosynthetic process [GO:0030148]	endoplasmic reticulum membrane [GO:0005789]	sphingolipid delta-4 desaturase activity [GO:0042284]; sphingosine hydroxylase activity [GO:0000170]	endoplasmic reticulum membrane [GO:0005789]; sphingolipid delta-4 desaturase activity [GO:0042284]; sphingosine hydroxylase activity [GO:0000170]; ceramide biosynthetic process [GO:0046513]; sphinganine metabolic process [GO:0006667]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R2F2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8R2F2}.
Q6QHF9	reviewed	PAOX_HUMAN	Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase)	PAOX PAO UNQ1923/PRO4398	Homo sapiens (Human)	511	FUNCTION: Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380). {ECO:0000269|PubMed:12477380}.	MISCELLANEOUS: Oxidizes N(1)-acetylated polyamines on the exo-side of their N(4)-amino groups. Plant PAO oxidizes spermine on the endo-side of the N(4)-nitrogen (By similarity). {ECO:0000250}.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	polyamine catabolic process [GO:0006598]; positive regulation of spermidine biosynthetic process [GO:1901307]; putrescine biosynthetic process [GO:0009446]; putrescine catabolic process [GO:0009447]; spermidine catabolic process [GO:0046203]; spermine catabolic process [GO:0046208]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]	N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [GO:0052899]; N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [GO:0052904]; N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [GO:0052903]; polyamine oxidase activity [GO:0046592]; spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity [GO:0052902]; spermine:oxygen oxidoreductase (spermidine-forming) activity [GO:0052901]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [GO:0052899]; N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [GO:0052904]; N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [GO:0052903]; polyamine oxidase activity [GO:0046592]; spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity [GO:0052902]; spermine:oxygen oxidoreductase (spermidine-forming) activity [GO:0052901]; polyamine catabolic process [GO:0006598]; positive regulation of spermidine biosynthetic process [GO:1901307]; putrescine biosynthetic process [GO:0009446]; putrescine catabolic process [GO:0009447]; spermidine catabolic process [GO:0046203]; spermine catabolic process [GO:0046208]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q6QHK4	reviewed	FIGLA_HUMAN	Factor in the germline alpha (FIGalpha) (Class C basic helix-loop-helix protein 8) (bHLHc8) (Folliculogenesis-specific basic helix-loop-helix protein) (Transcription factor FIGa)	FIGLA BHLHC8	Homo sapiens (Human)	219	FUNCTION: Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. {ECO:0000269|PubMed:15044608}.		developmental process [GO:0032502]; oocyte development [GO:0048599]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; developmental process [GO:0032502]; oocyte development [GO:0048599]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6QN14	reviewed	U17L6_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 6 (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 6) (Ubiquitin thioesterase 17-like protein 6) (Ubiquitin-specific-processing protease 17-like protein 6)	USP17L6P USP17C USP17D USP17N	Homo sapiens (Human)	398	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, cell migration, and the cellular response to viral infection. Seems to be non-functional in the regulation of apoptosis. {ECO:0000269|PubMed:17109758}.		protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; regulation of apoptotic process [GO:0042981]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17109758}. Cytoplasm {ECO:0000269|PubMed:17109758}.
Q6QNK2	reviewed	AGRD1_HUMAN	Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25)	ADGRD1 GPR133 PGR25	Homo sapiens (Human)	874	FUNCTION: Orphan receptor. Signals via G(s)-alpha family of G-proteins (PubMed:22025619, PubMed:22575658). Has protumorigenic function especially in glioblastoma (PubMed:27775701). {ECO:0000269|PubMed:22025619, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:27775701}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22025619, ECO:0000269|PubMed:25533341}; Multi-pass membrane protein {ECO:0000255}.
Q6QNY0	reviewed	BL1S3_HUMAN	Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3)	BLOC1S3 BLOS3	Homo sapiens (Human)	202	FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:16385460, ECO:0000269|PubMed:17182842}.		anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosome to melanosome transport [GO:0035646]; eye development [GO:0001654]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; pigmentation [GO:0043473]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell activation [GO:0032816]; response to xenobiotic stimulus [GO:0009410]; secretion of lysosomal enzymes [GO:0033299]	axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytosol [GO:0005829]; transport vesicle [GO:0030133]	protein transmembrane transporter activity [GO:0008320]	axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytosol [GO:0005829]; transport vesicle [GO:0030133]; protein transmembrane transporter activity [GO:0008320]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosome to melanosome transport [GO:0035646]; eye development [GO:0001654]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; pigmentation [GO:0043473]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell activation [GO:0032816]; response to xenobiotic stimulus [GO:0009410]; secretion of lysosomal enzymes [GO:0033299]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q6QNY1	reviewed	BL1S2_HUMAN	Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC-1 subunit 2) (Centrosome-associated protein)	BLOC1S2 BLOS2 CEAP	Homo sapiens (Human)	142	FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421). {ECO:0000250|UniProtKB:Q9CWG9, ECO:0000269|PubMed:15102850, ECO:0000269|PubMed:15381421, ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:25898167}.		anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosomal transport [GO:0016197]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; lysosome localization [GO:0032418]; melanosome organization [GO:0032438]; microtubule nucleation [GO:0007020]; mitochondrial outer membrane permeabilization [GO:0097345]; neuron projection development [GO:0031175]; organelle transport along microtubule [GO:0072384]; platelet dense granule organization [GO:0060155]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]	axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; BORC complex [GO:0099078]; centrosome [GO:0005813]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	gamma-tubulin binding [GO:0043015]	axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; BORC complex [GO:0099078]; centrosome [GO:0005813]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; gamma-tubulin binding [GO:0043015]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosomal transport [GO:0016197]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; lysosome localization [GO:0032418]; melanosome organization [GO:0032438]; microtubule nucleation [GO:0007020]; mitochondrial outer membrane permeabilization [GO:0097345]; neuron projection development [GO:0031175]; organelle transport along microtubule [GO:0072384]; platelet dense granule organization [GO:0060155]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15381421}. Lysosome membrane {ECO:0000305|PubMed:25898167}. Note=Localizes to the centrosomes in a microtubule-dependent manner. {ECO:0000269|PubMed:15381421}.
Q6R327	reviewed	RICTR_HUMAN	Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)	RICTOR KIAA1999	Homo sapiens (Human)	1708	FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. {ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; cellular response to nutrient levels [GO:0031669]; cytoskeleton organization [GO:0007010]; embryo development ending in birth or egg hatching [GO:0009792]; negative regulation of apoptotic process [GO:0043066]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of TOR signaling [GO:0032008]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of establishment of cell polarity [GO:2000114]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; TORC2 signaling [GO:0038203]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; TORC2 complex [GO:0031932]	molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; ribosome binding [GO:0043022]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; TORC2 complex [GO:0031932]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; ribosome binding [GO:0043022]; actin cytoskeleton organization [GO:0030036]; cellular response to nutrient levels [GO:0031669]; cytoskeleton organization [GO:0007010]; embryo development ending in birth or egg hatching [GO:0009792]; negative regulation of apoptotic process [GO:0043066]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of TOR signaling [GO:0032008]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of establishment of cell polarity [GO:2000114]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; TORC2 signaling [GO:0038203]	
Q6R6M4	reviewed	U17L2_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17 (USP17) (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 2) (Deubiquitinating protein 3) (DUB-3) (Ubiquitin carboxyl-terminal hydrolase 17-like protein 2) (Ubiquitin thioesterase 17-like protein 2) (Ubiquitin-specific-processing protease 17-like protein 2)	USP17L2 DUB3 USP17 USP17H USP17I USP17J USP17K USP17L USP17M	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection. {ECO:0000269|PubMed:14699124, ECO:0000269|PubMed:17109758, ECO:0000269|PubMed:19188362, ECO:0000269|PubMed:20147298, ECO:0000269|PubMed:20228808, ECO:0000269|PubMed:20368735, ECO:0000269|PubMed:20388806, ECO:0000269|PubMed:21239494, ECO:0000269|PubMed:21448158}.	MISCELLANEOUS: Overexpressed in a subset of human breast cancers, overexpression leading to an abnormally high level of CDC25A, which arrests cells through replication stress or premature mitosis, the latter occurring when CDK1 is activated inappropriately. {ECO:0000305|PubMed:20228808}.	apoptotic process [GO:0006915]; CAAX-box protein processing [GO:0071586]; cell cycle [GO:0007049]; MAPK cascade [GO:0000165]; negative regulation of GTPase activity [GO:0034260]; negative regulation of protein processing [GO:0010955]; negative regulation of protein targeting to membrane [GO:0090315]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of defense response to virus by host [GO:0050691]; regulation of G2/MI transition of meiotic cell cycle [GO:0110030]; regulation of ruffle assembly [GO:1900027]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; apoptotic process [GO:0006915]; CAAX-box protein processing [GO:0071586]; cell cycle [GO:0007049]; MAPK cascade [GO:0000165]; negative regulation of GTPase activity [GO:0034260]; negative regulation of protein processing [GO:0010955]; negative regulation of protein targeting to membrane [GO:0090315]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of defense response to virus by host [GO:0050691]; regulation of G2/MI transition of meiotic cell cycle [GO:0110030]; regulation of ruffle assembly [GO:1900027]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21239494}. Endoplasmic reticulum {ECO:0000269|PubMed:19188362}.
Q6RFH5	reviewed	WDR74_HUMAN	WD repeat-containing protein 74 (NOP seven-associated protein 1)	WDR74 NSA1	Homo sapiens (Human)	385	FUNCTION: Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit (PubMed:26456651). Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (PubMed:29107693). Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity). {ECO:0000250|UniProtKB:Q8VCG3, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:29107693}.		blastocyst formation [GO:0001825]; ribosomal large subunit biogenesis [GO:0042273]; RNA metabolic process [GO:0016070]; rRNA processing [GO:0006364]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]		nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; blastocyst formation [GO:0001825]; ribosomal large subunit biogenesis [GO:0042273]; RNA metabolic process [GO:0016070]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}. Nucleus {ECO:0000269|PubMed:28416111}. Note=Nucleolar location depends on active PolI transcription of pre-rRNA. {ECO:0000269|PubMed:28416111}.
Q6RFH8	reviewed	DUX4C_HUMAN	Double homeobox protein 4C (Double homeobox protein 4, centromeric) (DUX4c) (Double homeobox protein 4-like protein 9)	DUX4L9 DUX4C	Homo sapiens (Human)	374	FUNCTION: May be involved in transcriptional regulation (By similarity). Down-regulates MYOD1 expression and may up-regulate MYF5 expression. May regulate microRNA (miRNA) transcription, up-regulating the expression of some myogenic miRNAs, including MIR1-1, MIR133A2, MIR133B and MIR206. Impairs the differentiation of myoblasts and may be involved in muscle regeneration. {ECO:0000250, ECO:0000269|PubMed:18723017, ECO:0000269|PubMed:19829708, ECO:0000269|PubMed:24145033}.		cell population proliferation [GO:0008283]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; cell population proliferation [GO:0008283]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:19829708}.
Q6RI45	reviewed	BRWD3_HUMAN	Bromodomain and WD repeat-containing protein 3	BRWD3	Homo sapiens (Human)	1802	FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:21834987}.		cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]		nucleus [GO:0005634]; cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q6RVD6	reviewed	SPAT8_HUMAN	Spermatogenesis-associated protein 8 (Spermatogenesis-related protein 8)	SPATA8	Homo sapiens (Human)	105							
Q6RW13	reviewed	ATRAP_HUMAN	Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein)	AGTRAP ATRAP	Homo sapiens (Human)	159	FUNCTION: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. {ECO:0000269|PubMed:12960423}.		regulation of blood pressure [GO:0008217]; response to hypoxia [GO:0001666]	cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	angiotensin type II receptor activity [GO:0004945]; identical protein binding [GO:0042802]	cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; angiotensin type II receptor activity [GO:0004945]; identical protein binding [GO:0042802]; regulation of blood pressure [GO:0008217]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12960423}; Multi-pass membrane protein {ECO:0000269|PubMed:12960423}. Golgi apparatus membrane {ECO:0000269|PubMed:12960423}; Multi-pass membrane protein {ECO:0000269|PubMed:12960423}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12960423}; Multi-pass membrane protein {ECO:0000269|PubMed:12960423}. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
Q6S5L8	reviewed	SHC4_HUMAN	SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)	SHC4 SHCD UNQ6438/PRO21364	Homo sapiens (Human)	630	FUNCTION: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17409413}.		apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of cell population proliferation [GO:0008284]; regulation of gene expression [GO:0010468]; stem cell differentiation [GO:0048863]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	protein domain specific binding [GO:0019904]; receptor tyrosine kinase binding [GO:0030971]	plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; protein domain specific binding [GO:0019904]; receptor tyrosine kinase binding [GO:0030971]; apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of cell population proliferation [GO:0008284]; regulation of gene expression [GO:0010468]; stem cell differentiation [GO:0048863]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction. {ECO:0000250}.
Q6S8J3	reviewed	POTEE_HUMAN	POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2)	POTEE A26C1A POTE2	Homo sapiens (Human)	1075			axonogenesis [GO:0007409]; cell motility [GO:0048870]; retina homeostasis [GO:0001895]; substantia nigra development [GO:0021762]	actin filament [GO:0005884]; axon [GO:0030424]; blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202]	protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]	actin filament [GO:0005884]; axon [GO:0030424]; blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202]; protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; retina homeostasis [GO:0001895]; substantia nigra development [GO:0021762]	
Q6S9Z5	reviewed	ZN474_HUMAN	Zinc finger protein 474 (Testis-specific zinc finger protein) (TSZFP)	ZNF474	Homo sapiens (Human)	364					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q6SA08	reviewed	TSSK4_HUMAN	Testis-specific serine/threonine-protein kinase 4 (TSK-4) (TSSK-4) (Testis-specific kinase 4) (EC 2.7.11.1) (Serine/threonine-protein kinase 22E)	TSSK4 C14orf20 STK22E TSSK5	Homo sapiens (Human)	328	FUNCTION: Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed:15964553). Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity). {ECO:0000250|UniProtKB:Q9D411, ECO:0000269|PubMed:15964553}.		fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; intracellular signal transduction [GO:0035556]; positive regulation of CREB transcription factor activity [GO:0032793]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286]	acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; intracellular signal transduction [GO:0035556]; positive regulation of CREB transcription factor activity [GO:0032793]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9D411}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D411}. Note=In spermatozoa, present in the sperm head and in the flagellum. {ECO:0000250|UniProtKB:Q9D411}.
Q6SJ93	reviewed	F111B_HUMAN	Serine protease FAM111B (EC 3.4.21.-) (Cancer-associated nucleoprotein)	FAM111B CANP	Homo sapiens (Human)	734	FUNCTION: Serine protease. {ECO:0000250|UniProtKB:Q96PZ2}.		DNA replication [GO:0006260]; proteolysis [GO:0006508]	chromatin [GO:0000785]; nucleus [GO:0005634]	peptidase activity [GO:0008233]	chromatin [GO:0000785]; nucleus [GO:0005634]; peptidase activity [GO:0008233]; DNA replication [GO:0006260]; proteolysis [GO:0006508]	
Q6SPF0	reviewed	SAMD1_HUMAN	Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin)	SAMD1	Homo sapiens (Human)	538	FUNCTION: Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:16159594, PubMed:34006929). {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:33980486, ECO:0000269|PubMed:34006929}.		chromatin organization [GO:0006325]; foam cell differentiation [GO:0090077]; lipoprotein lipid oxidation [GO:0034439]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein homooligomerization [GO:0051260]; regulation of DNA methylation-dependent heterochromatin formation [GO:0090308]	chromosome [GO:0005694]; extracellular space [GO:0005615]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; low-density lipoprotein particle binding [GO:0030169]	chromosome [GO:0005694]; extracellular space [GO:0005615]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; low-density lipoprotein particle binding [GO:0030169]; chromatin organization [GO:0006325]; foam cell differentiation [GO:0090077]; lipoprotein lipid oxidation [GO:0034439]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein homooligomerization [GO:0051260]; regulation of DNA methylation-dependent heterochromatin formation [GO:0090308]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34006929}. Chromosome {ECO:0000269|PubMed:34006929}. Secreted {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:34006929}. Note=In atherosclerotic lesions, it is found in the extracellular compartment and in foam cells cytoplasm. {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:34006929}.
Q6STE5	reviewed	SMRD3_HUMAN	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (60 kDa BRG-1/Brm-associated factor subunit C) (BRG1-associated factor 60C) (BAF60C)	SMARCD3 BAF60C	Homo sapiens (Human)	483	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6P9Z1, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:8804307, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.		cardiac right ventricle formation [GO:0003219]; chromatin remodeling [GO:0006338]; muscle cell differentiation [GO:0042692]; nervous system development [GO:0007399]; neural retina development [GO:0003407]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; secondary heart field specification [GO:0003139]	brahma complex [GO:0035060]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription coregulator binding [GO:0001221]	brahma complex [GO:0035060]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription coregulator binding [GO:0001221]; cardiac right ventricle formation [GO:0003219]; chromatin remodeling [GO:0006338]; muscle cell differentiation [GO:0042692]; nervous system development [GO:0007399]; neural retina development [GO:0003407]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; secondary heart field specification [GO:0003139]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14701856}.
Q6SZW1	reviewed	SARM1_HUMAN	NAD(+) hydrolase SARM1 (NADase SARM1) (hSARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and Armadillo repeat protein) (Sterile alpha and TIR motif-containing protein 1) (Sterile alpha motif domain-containing protein 2) (MyD88-5) (SAM domain-containing protein 2) (Tir-1 homolog) (HsTIR)	SARM1 KIAA0524 SAMD2 SARM	Homo sapiens (Human)	724	FUNCTION: NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:32049506, PubMed:32828421, PubMed:31439792, PubMed:33053563). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262). {ECO:0000250|UniProtKB:Q6PDS3, ECO:0000269|PubMed:15123841, ECO:0000269|PubMed:16964262, ECO:0000269|PubMed:20306472, ECO:0000269|PubMed:25908823, ECO:0000269|PubMed:27671644, ECO:0000269|PubMed:28334607, ECO:0000269|PubMed:29395922, ECO:0000269|PubMed:30333228, ECO:0000269|PubMed:31128467, ECO:0000269|PubMed:31439792, ECO:0000269|PubMed:31439793, ECO:0000269|PubMed:32049506, ECO:0000269|PubMed:32828421, ECO:0000269|PubMed:33053563}.		cell differentiation [GO:0030154]; innate immune response [GO:0045087]; NAD catabolic process [GO:0019677]; negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128]; nervous system development [GO:0007399]; protein localization to mitochondrion [GO:0070585]; regulation of dendrite morphogenesis [GO:0048814]; regulation of neuron apoptotic process [GO:0043523]; response to axon injury [GO:0048678]; response to glucose [GO:0009749]; signal transduction [GO:0007165]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; synapse [GO:0045202]	identical protein binding [GO:0042802]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling adaptor activity [GO:0035591]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; synapse [GO:0045202]; identical protein binding [GO:0042802]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling adaptor activity [GO:0035591]; cell differentiation [GO:0030154]; innate immune response [GO:0045087]; NAD catabolic process [GO:0019677]; negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128]; nervous system development [GO:0007399]; protein localization to mitochondrion [GO:0070585]; regulation of dendrite morphogenesis [GO:0048814]; regulation of neuron apoptotic process [GO:0043523]; response to axon injury [GO:0048678]; response to glucose [GO:0009749]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20306472}. Cell projection, axon {ECO:0000250|UniProtKB:Q6PDS3}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q6PDS3}. Synapse {ECO:0000250|UniProtKB:Q6PDS3}. Mitochondrion {ECO:0000269|PubMed:20306472, ECO:0000269|PubMed:22145856}. Note=Associated with microtubules. {ECO:0000250|UniProtKB:Q6PDS3}.
Q6T4R5	reviewed	NHS_HUMAN	Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein)	NHS	Homo sapiens (Human)	1651	FUNCTION: May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}.		cell differentiation [GO:0030154]; lens development in camera-type eye [GO:0002088]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nuclear body [GO:0016604]		apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nuclear body [GO:0016604]; cell differentiation [GO:0030154]; lens development in camera-type eye [GO:0002088]	SUBCELLULAR LOCATION: [Isoform 1]: Apical cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, tight junction. Cell junction, focal adhesion. Note=Colocalizes with the tight junction protein TJP1 in epithelial cells. Localizes to the leading edge of lamellipodia in motile cells.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Q6TCH4	reviewed	PAQR6_HUMAN	Membrane progestin receptor delta (mPR delta) (Membrane progesterone P4 receptor delta) (Membrane progesterone receptor delta) (Progesterone and adipoQ receptor family member 6) (Progestin and adipoQ receptor family member 6)	PAQR6	Homo sapiens (Human)	344	FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23763432, PubMed:23161870). {ECO:0000269|PubMed:23161870, ECO:0000303|PubMed:23763432}.	MISCELLANEOUS: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). {ECO:0000303|PubMed:23763432}.		plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]; steroid binding [GO:0005496]	plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; steroid binding [GO:0005496]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23161870}; Multi-pass membrane protein {ECO:0000255}.
Q6TCH7	reviewed	PAQR3_HUMAN	Progestin and adipoQ receptor family member 3 (Progestin and adipoQ receptor family member III) (Raf kinase trapping to Golgi) (RKTG)	PAQR3	Homo sapiens (Human)	311	FUNCTION: Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi. {ECO:0000269|PubMed:18547165}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein phosphorylation [GO:0001933]; protein localization to Golgi apparatus [GO:0034067]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	signaling receptor activity [GO:0038023]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; signaling receptor activity [GO:0038023]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein phosphorylation [GO:0001933]; protein localization to Golgi apparatus [GO:0034067]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:18547165}; Multi-pass membrane protein {ECO:0000269|PubMed:18547165}.
Q6TFL4	reviewed	KLH24_HUMAN	Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1)	KLHL24 DRE1	Homo sapiens (Human)	600	FUNCTION: Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Has a crucial role in cardiac development and function (PubMed:30715372). {ECO:0000250|UniProtKB:Q56A24, ECO:0000269|PubMed:27798626, ECO:0000269|PubMed:27889062, ECO:0000269|PubMed:30715372}.		intermediate filament organization [GO:0045109]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	adherens junction [GO:0005912]; axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; perikaryon [GO:0043204]		adherens junction [GO:0005912]; axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; perikaryon [GO:0043204]; intermediate filament organization [GO:0045109]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Perikaryon. Cell projection, axon {ECO:0000250|UniProtKB:Q56A24}. Cytoplasm {ECO:0000250|UniProtKB:Q56A24, ECO:0000269|PubMed:27889062}. Cell junction, desmosome {ECO:0000269|PubMed:27889062}. Cell junction, adherens junction {ECO:0000269|PubMed:27889062}.
Q6TGC4	reviewed	PADI6_HUMAN	Protein-arginine deiminase type-6 (EC 3.5.3.15) (Peptidyl arginine deiminase-like protein) (Peptidylarginine deiminase VI) (hPADVI) (Protein-arginine deiminase type VI)	PADI6 PAD6	Homo sapiens (Human)	694	FUNCTION: Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678). {ECO:0000250, ECO:0000269|PubMed:27545678}.; FUNCTION: Catalyzes the deimination of arginine residues of proteins (By similarity). In oocytes, is released during cortical reaction and plays a role in preimplantation cleavage and early embryonic development (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678). {ECO:0000250, ECO:0000250|UniProtKB:Q8K3V4, ECO:0000269|PubMed:27545678}.		cytoplasm organization [GO:0007028]; cytoskeleton organization [GO:0007010]; embryonic cleavage [GO:0040016]; regulation of translation by machinery localization [GO:0043143]	cortical granule [GO:0060473]; cytoplasm [GO:0005737]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; protein-arginine deiminase activity [GO:0004668]	cortical granule [GO:0060473]; cytoplasm [GO:0005737]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; protein-arginine deiminase activity [GO:0004668]; cytoplasm organization [GO:0007028]; cytoskeleton organization [GO:0007010]; embryonic cleavage [GO:0040016]; regulation of translation by machinery localization [GO:0043143]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27545678}. Nucleus {ECO:0000250|UniProtKB:Q8K3V4}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8K3V4}. Note=Predominantly cytoplasmic (oocyte cytoplasmic sheets), also nuclear. Released extracellularly during the cortical reaction, and remains associated with the blastomeres surfaces as a peripheral membrane protein until the blastocyst stage of development. {ECO:0000250|UniProtKB:Q8K3V4}.
Q6U736	reviewed	OPN5_HUMAN	Opsin-5 (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Neuropsin) (Transmembrane protein 13)	OPN5 GPR136 PGR12 TMEM13	Homo sapiens (Human)	354	FUNCTION: G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (By similarity). Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) (PubMed:22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (By similarity). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (By similarity). Acts as a circadian photoreceptor in the outer ear, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (By similarity). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (By similarity). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (By similarity). {ECO:0000250|UniProtKB:Q6VZZ7, ECO:0000269|PubMed:22043319}.		cellular response to light stimulus [GO:0071482]; cellular response to UV-A [GO:0071492]; entrainment of circadian clock by photoperiod [GO:0043153]; G protein-coupled receptor signaling pathway [GO:0007186]; hyaloid vascular plexus regression [GO:1990384]; phototransduction [GO:0007602]; phototransduction, UV [GO:0007604]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; 11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020]; cellular response to light stimulus [GO:0071482]; cellular response to UV-A [GO:0071492]; entrainment of circadian clock by photoperiod [GO:0043153]; G protein-coupled receptor signaling pathway [GO:0007186]; hyaloid vascular plexus regression [GO:1990384]; phototransduction [GO:0007602]; phototransduction, UV [GO:0007604]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q6U7Q0	reviewed	ZN322_HUMAN	Zinc finger protein 322 (Zinc finger protein 322A) (Zinc finger protein 388) (Zinc finger protein 489)	ZNF322 ZNF322A ZNF388 ZNF489	Homo sapiens (Human)	402	FUNCTION: Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZ89, ECO:0000269|PubMed:15555580}.	MISCELLANEOUS: Significantly enhances POU5F1/OCT4-SOX2-KLF4-MYC (OSKM) mediated reprogramming of mouse embryonic fibroblasts into induced pluripotent stem cells, and can also substitute for SOX2 in this process. {ECO:0000250|UniProtKB:Q8BZ89}.	positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]	centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15555580}. Nucleus {ECO:0000269|PubMed:15555580}. Note=Mainly found in the nucleus. {ECO:0000269|PubMed:15555580}.
Q6U841	reviewed	S4A10_HUMAN	Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10)	SLC4A10 NBCN2 NCBE	Homo sapiens (Human)	1118	FUNCTION: Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:18319254). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (PubMed:18319254). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity). {ECO:0000250|UniProtKB:Q5DTL9, ECO:0000250|UniProtKB:Q80ZA5, ECO:0000269|PubMed:18319254}.		bicarbonate transport [GO:0015701]; brain morphogenesis [GO:0048854]; chloride transport [GO:0006821]; locomotory exploration behavior [GO:0035641]; multicellular organism growth [GO:0035264]; post-embryonic development [GO:0009791]; proton transmembrane transport [GO:1902600]; pyramidal neuron development [GO:0021860]; regulation of intracellular pH [GO:0051453]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to light stimulus [GO:0009416]; transmembrane transport [GO:0055085]; visual perception [GO:0007601]	apical dendrite [GO:0097440]; apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; basal dendrite [GO:0097441]; basolateral plasma membrane [GO:0016323]; CA3 pyramidal cell dendrite [GO:0097442]; dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; somatodendritic compartment [GO:0036477]; synapse [GO:0045202]	sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]	apical dendrite [GO:0097440]; apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; basal dendrite [GO:0097441]; basolateral plasma membrane [GO:0016323]; CA3 pyramidal cell dendrite [GO:0097442]; dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; somatodendritic compartment [GO:0036477]; synapse [GO:0045202]; sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]; bicarbonate transport [GO:0015701]; brain morphogenesis [GO:0048854]; chloride transport [GO:0006821]; locomotory exploration behavior [GO:0035641]; multicellular organism growth [GO:0035264]; post-embryonic development [GO:0009791]; proton transmembrane transport [GO:1902600]; pyramidal neuron development [GO:0021860]; regulation of intracellular pH [GO:0051453]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to light stimulus [GO:0009416]; transmembrane transport [GO:0055085]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q5DTL9}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q80ZA5}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q5DTL9}. Cell projection, axon {ECO:0000250|UniProtKB:Q5DTL9}. Perikaryon {ECO:0000250|UniProtKB:Q5DTL9}. Presynapse {ECO:0000250|UniProtKB:Q5DTL9}. Postsynapse {ECO:0000250|UniProtKB:Q5DTL9}. Note=Detected in dendrites and axon terminals of retinal OFF bipolar cells and in axon terminals of ON bipolar cells. In amacrine cells, located in the perikaryon. Also detected in basal and apical dendrites of hippocampal pyramidal cells. {ECO:0000250|UniProtKB:Q5DTL9}.
Q6UB28	reviewed	MAP12_HUMAN	Methionine aminopeptidase 1D, mitochondrial (MAP 1D) (MetAP 1D) (EC 3.4.11.18) (Methionyl aminopeptidase type 1D, mitochondrial) (Peptidase M 1D)	METAP1D MAP1D	Homo sapiens (Human)	335	FUNCTION: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis. {ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:16568094}.		N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; proteolysis [GO:0006508]	mitochondrion [GO:0005739]	aminopeptidase activity [GO:0004177]; initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]	mitochondrion [GO:0005739]; aminopeptidase activity [GO:0004177]; initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:14532271}.
Q6UB35	reviewed	C1TM_HUMAN	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase)	MTHFD1L FTHFSDC1	Homo sapiens (Human)	978	FUNCTION: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}.	MISCELLANEOUS: May participate in the progression of colorectal cancer by conferring growth advantage. Could be a new molecular target for cancer therapy.	10-formyltetrahydrofolate biosynthetic process [GO:0009257]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; folic acid-containing compound metabolic process [GO:0006760]; formate metabolic process [GO:0015942]; neural tube closure [GO:0001843]; tetrahydrofolate interconversion [GO:0035999]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; protein homodimerization activity [GO:0042803]; 10-formyltetrahydrofolate biosynthetic process [GO:0009257]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; folic acid-containing compound metabolic process [GO:0006760]; formate metabolic process [GO:0015942]; neural tube closure [GO:0001843]; tetrahydrofolate interconversion [GO:0035999]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12937168}.
Q6UB98	reviewed	ANR12_HUMAN	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein)	ANKRD12 ANCO2 KIAA0874	Homo sapiens (Human)	2062	FUNCTION: May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.			cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15184363, ECO:0000269|Ref.2}.
Q6UB99	reviewed	ANR11_HUMAN	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1)	ANKRD11 ANCO1	Homo sapiens (Human)	2663	FUNCTION: Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.		face morphogenesis [GO:0060325]; odontogenesis of dentin-containing tooth [GO:0042475]; skeletal system morphogenesis [GO:0048705]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; face morphogenesis [GO:0060325]; odontogenesis of dentin-containing tooth [GO:0042475]; skeletal system morphogenesis [GO:0048705]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25413698, ECO:0000269|PubMed:25556659, ECO:0000269|Ref.1}. Note=Localizes to chromatin during prometaphase. {ECO:0000269|PubMed:25413698}.
Q6ULP2	reviewed	AFTIN_HUMAN	Aftiphilin	AFTPH AFTH	Homo sapiens (Human)	936	FUNCTION: Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}.	MISCELLANEOUS: [Isoform 3]: May be due to intron retention. {ECO:0000305}.	intracellular transport [GO:0046907]; protein transport [GO:0015031]	AP-1 adaptor complex [GO:0030121]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network membrane [GO:0032588]	clathrin binding [GO:0030276]	AP-1 adaptor complex [GO:0030121]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network membrane [GO:0032588]; clathrin binding [GO:0030276]; intracellular transport [GO:0046907]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14665628, ECO:0000269|PubMed:15758025}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15758025}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:15758025}. Note=Co-localizes with AP1G1/AP-1 in the cytoplasm (PubMed:14665628, PubMed:15758025). Recruited to the perinuclear region by AP1G1/AP-1 (PubMed:15758025). {ECO:0000269|PubMed:14665628, ECO:0000269|PubMed:15758025}.
Q6UN15	reviewed	FIP1_HUMAN	Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia)	FIP1L1 FIP1 RHE	Homo sapiens (Human)	594	FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}.		mRNA processing [GO:0006397]	cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]	SUBCELLULAR LOCATION: Nucleus.
Q6UUV7	reviewed	CRTC3_HUMAN	CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3)	CRTC3 TORC3	Homo sapiens (Human)	619	FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}.		energy homeostasis [GO:0097009]; lipid catabolic process [GO:0016042]; macrophage activation [GO:0042116]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of lipid catabolic process [GO:0050995]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homotetramerization [GO:0051289]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cAMP response element binding protein binding [GO:0008140]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cAMP response element binding protein binding [GO:0008140]; energy homeostasis [GO:0097009]; lipid catabolic process [GO:0016042]; macrophage activation [GO:0042116]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of lipid catabolic process [GO:0050995]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homotetramerization [GO:0051289]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:30611118}. Cytoplasm {ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:30611118}. Note=Appears to be mainly nuclear (PubMed:15454081). Translocates to the nucleus following adenylyl cyclase or MAP kinase activation (PubMed:30611118). {ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:30611118}.
Q6UUV9	reviewed	CRTC1_HUMAN	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)	CRTC1 KIAA0616 MECT1 TORC1 WAMTP1	Homo sapiens (Human)	634	FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}.		energy homeostasis [GO:0097009]; entrainment of circadian clock by photoperiod [GO:0043153]; memory [GO:0007613]; negative regulation of membrane hyperpolarization [GO:1902631]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homotetramerization [GO:0051289]; rhythmic process [GO:0048511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cAMP response element binding protein binding [GO:0008140]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cAMP response element binding protein binding [GO:0008140]; energy homeostasis [GO:0097009]; entrainment of circadian clock by photoperiod [GO:0043153]; memory [GO:0007613]; negative regulation of membrane hyperpolarization [GO:1902631]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homotetramerization [GO:0051289]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15589160}. Nucleus {ECO:0000269|PubMed:15589160}. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (PubMed:16817901). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (PubMed:15589160). Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (By similarity). {ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901}.
Q6UVJ0	reviewed	SAS6_HUMAN	Spindle assembly abnormal protein 6 homolog (HsSAS-6)	SASS6 SAS6	Homo sapiens (Human)	657	FUNCTION: Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). {ECO:0000269|PubMed:15665853, ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:22020124}.		centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; positive regulation of centriole replication [GO:0046601]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of spindle assembly [GO:1905832]; regulation of mitotic spindle organization [GO:0060236]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; deuterosome [GO:0098536]; procentriole replication complex [GO:0120099]		centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; deuterosome [GO:0098536]; procentriole replication complex [GO:0120099]; centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; positive regulation of centriole replication [GO:0046601]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of spindle assembly [GO:1905832]; regulation of mitotic spindle organization [GO:0060236]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15665853, ECO:0000269|PubMed:24107630, ECO:0000269|PubMed:31722219}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15572125, ECO:0000269|PubMed:15665853, ECO:0000269|PubMed:17681131}. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity). Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis. {ECO:0000250|UniProtKB:Q80UK7}.
Q6UVK1	reviewed	CSPG4_HUMAN	Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan)	CSPG4 MCSP	Homo sapiens (Human)	2322	FUNCTION: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. {ECO:0000269|PubMed:10587647, ECO:0000269|PubMed:11278606, ECO:0000269|PubMed:15210734}.	MISCELLANEOUS: Valuable marker for several incompletely differentiated precursor cells.	angiogenesis [GO:0001525]; glial cell migration [GO:0008347]; intracellular signal transduction [GO:0035556]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; ruffle assembly [GO:0097178]; substrate-dependent cell migration [GO:0006929]; tissue remodeling [GO:0048771]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lamellipodium membrane [GO:0031258]; lysosomal lumen [GO:0043202]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	coreceptor activity [GO:0015026]; protein kinase binding [GO:0019901]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lamellipodium membrane [GO:0031258]; lysosomal lumen [GO:0043202]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; coreceptor activity [GO:0015026]; protein kinase binding [GO:0019901]; angiogenesis [GO:0001525]; glial cell migration [GO:0008347]; intracellular signal transduction [GO:0035556]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; ruffle assembly [GO:0097178]; substrate-dependent cell migration [GO:0006929]; tissue remodeling [GO:0048771]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Apical cell membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Cell surface {ECO:0000250|UniProtKB:Q00657}. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). {ECO:0000250|UniProtKB:Q00657, ECO:0000250|UniProtKB:Q8VHY0}.
Q6UVM3	reviewed	KCNT2_HUMAN	Potassium channel subfamily T member 2 (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1)	KCNT2 SLICK	Homo sapiens (Human)	1135	FUNCTION: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:16687497, PubMed:29069600). Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:16687497) (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (PubMed:16687497). {ECO:0000250|UniProtKB:Q6UVM4, ECO:0000269|PubMed:14684870, ECO:0000269|PubMed:16687497, ECO:0000269|PubMed:29069600}.		potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]	plasma membrane [GO:0005886]	ATP binding [GO:0005524]; chloride-activated potassium channel activity [GO:0070089]; intracellular sodium activated potassium channel activity [GO:0005228]; outward rectifier potassium channel activity [GO:0015271]	plasma membrane [GO:0005886]; ATP binding [GO:0005524]; chloride-activated potassium channel activity [GO:0070089]; intracellular sodium activated potassium channel activity [GO:0005228]; outward rectifier potassium channel activity [GO:0015271]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29069600}; Multi-pass membrane protein {ECO:0000255}.
Q6UVW9	reviewed	CLC2A_HUMAN	C-type lectin domain family 2 member A (Keratinocyte-associated C-type lectin) (KACL) (Proliferation-induced lymphocyte-associated receptor) (PILAR)	CLEC2A KACL UNQ5792/PRO19597	Homo sapiens (Human)	174	FUNCTION: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. {ECO:0000269|PubMed:18550855, ECO:0000269|PubMed:20194751}.		natural killer cell mediated cytotoxicity [GO:0042267]	plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; protein homodimerization activity [GO:0042803]	plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; protein homodimerization activity [GO:0042803]; natural killer cell mediated cytotoxicity [GO:0042267]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18046548, ECO:0000269|PubMed:18550855}; Single-pass type II membrane protein {ECO:0000269|PubMed:18046548, ECO:0000269|PubMed:18550855}.
Q6UVY6	reviewed	MOXD1_HUMAN	DBH-like monooxygenase protein 1 (EC 1.14.17.-) (Monooxygenase X)	MOXD1 MOX UNQ2493/PRO5780	Homo sapiens (Human)	613		MISCELLANEOUS: [Isoform 1]: Major.	dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]	endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; secretory granule membrane [GO:0030667]	copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]	endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; secretory granule membrane [GO:0030667]; copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q6UW15	reviewed	REG3G_HUMAN	Regenerating islet-derived protein 3-gamma (REG-3-gamma) (Pancreatitis-associated protein 1B) (PAP-1B) (Pancreatitis-associated protein IB) (PAP IB) (Regenerating islet-derived protein III-gamma) (REG III) (Reg III-gamma) [Cleaved into: Regenerating islet-derived protein 3-gamma 16.5 kDa form; Regenerating islet-derived protein 3-gamma 15 kDa form]	REG3G PAP1B UNQ429/PRO162	Homo sapiens (Human)	175	FUNCTION: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. {ECO:0000269|PubMed:19095652}.; FUNCTION: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation. Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents. Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia. {ECO:0000250|UniProtKB:O09049}.; FUNCTION: [Regenerating islet-derived protein 3-gamma 16.5 kDa form]: Has bacteriostatic activity. {ECO:0000269|PubMed:19095652}.; FUNCTION: [Regenerating islet-derived protein 3-gamma 15 kDa form]: Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. {ECO:0000269|PubMed:19095652}.		acute-phase response [GO:0006953]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell wall disruption in another organism [GO:0044278]; defense response to Gram-positive bacterium [GO:0050830]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of keratinocyte differentiation [GO:0045617]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of wound healing [GO:0090303]; response to peptide hormone [GO:0043434]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	metal ion binding [GO:0046872]; oligosaccharide binding [GO:0070492]; peptidoglycan binding [GO:0042834]; signaling receptor activity [GO:0038023]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; metal ion binding [GO:0046872]; oligosaccharide binding [GO:0070492]; peptidoglycan binding [GO:0042834]; signaling receptor activity [GO:0038023]; acute-phase response [GO:0006953]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell wall disruption in another organism [GO:0044278]; defense response to Gram-positive bacterium [GO:0050830]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of keratinocyte differentiation [GO:0045617]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of wound healing [GO:0090303]; response to peptide hormone [GO:0043434]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P42854}. Cytoplasm {ECO:0000250|UniProtKB:P42854}.
Q6UW56	reviewed	ARAID_HUMAN	All-trans retinoic acid-induced differentiation factor (Apoptosis-related protein 3) (APR-3) (p18)	ATRAID APR3 C2orf28 HSPC013 UNQ214/PRO240	Homo sapiens (Human)	229	FUNCTION: Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899). {ECO:0000269|PubMed:21723284, ECO:0000269|PubMed:29745899}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000305}.	cell differentiation [GO:0030154]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of gene expression [GO:0010468]; xenobiotic transmembrane transport [GO:0006855]	intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	xenobiotic transmembrane transporter activity [GO:0042910]	intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; xenobiotic transmembrane transporter activity [GO:0042910]; cell differentiation [GO:0030154]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of gene expression [GO:0010468]; xenobiotic transmembrane transport [GO:0006855]	SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:21723284}. Cell membrane {ECO:0000269|PubMed:17524364}; Single-pass membrane protein {ECO:0000269|PubMed:17524364}. Lysosome membrane {ECO:0000269|PubMed:29745899}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with NELL1 on the nuclear envelope and the perinuclear region (PubMed:21723284).
Q6UW60	reviewed	PCSK4_HUMAN	Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4)	PCSK4 PC4 UNQ2757/PRO6496	Homo sapiens (Human)	755	FUNCTION: Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Also plays a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806). May also participate in folliculogenesis in the ovaries (By similarity). {ECO:0000250|UniProtKB:P29121, ECO:0000269|PubMed:16040806}.		acrosome reaction [GO:0007340]; binding of sperm to zona pellucida [GO:0007339]; fertilization [GO:0009566]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]; reproductive process [GO:0022414]; sperm capacitation [GO:0048240]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	serine-type endopeptidase activity [GO:0004252]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; serine-type endopeptidase activity [GO:0004252]; acrosome reaction [GO:0007340]; binding of sperm to zona pellucida [GO:0007339]; fertilization [GO:0009566]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]; reproductive process [GO:0022414]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P29121}.
Q6UW63	reviewed	PLGT2_HUMAN	Protein O-glucosyltransferase 2 (EC 2.4.1.-) (Endoplasmic reticulum resident protein 58) (ER protein 58) (ERp58) (KDEL motif-containing protein 1) (Protein O-xylosyltransferase POGLUT2) (EC 2.4.2.-)	POGLUT2 EP58 KDELC1 UNQ1910/PRO4357	Homo sapiens (Human)	502	FUNCTION: Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1 (PubMed:30127001, PubMed:34411563). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001). {ECO:0000269|PubMed:30127001, ECO:0000269|PubMed:34411563}.		protein O-linked glycosylation via serine [GO:0018242]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum lumen [GO:0005788]; nucleoplasm [GO:0005654]	EGF-domain serine glucosyltransferase activity [GO:0140561]; EGF-domain serine xylosyltransferase activity [GO:0140562]; glucosyltransferase activity [GO:0046527]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum lumen [GO:0005788]; nucleoplasm [GO:0005654]; EGF-domain serine glucosyltransferase activity [GO:0140561]; EGF-domain serine xylosyltransferase activity [GO:0140562]; glucosyltransferase activity [GO:0046527]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252]; protein O-linked glycosylation via serine [GO:0018242]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q6UW68	reviewed	TM205_HUMAN	Transmembrane protein 205	TMEM205 UNQ501/PRO1018	Homo sapiens (Human)	189	FUNCTION: In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin. {ECO:0000269|PubMed:20589834}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:20589834}; Multi-pass membrane protein {ECO:0000269|PubMed:20589834}. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.
Q6UW78	reviewed	UQCC3_HUMAN	Ubiquinol-cytochrome-c reductase complex assembly factor 3 (Assembly factor CBP4 homolog)	UQCC3 C11orf83 UNQ655/PRO1286	Homo sapiens (Human)	93	FUNCTION: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. {ECO:0000269|PubMed:25008109, ECO:0000269|PubMed:25605331}.		ATP biosynthetic process [GO:0006754]; cristae formation [GO:0042407]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; mitochondrial respiratory chain complex III assembly [GO:0034551]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]; ATP biosynthetic process [GO:0006754]; cristae formation [GO:0042407]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; mitochondrial respiratory chain complex III assembly [GO:0034551]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:25008109, ECO:0000269|PubMed:25605331}; Single-pass membrane protein {ECO:0000269|PubMed:25008109, ECO:0000269|PubMed:25605331}.
Q6UW88	reviewed	EPGN_HUMAN	Epigen (Epithelial mitogen) (EPG)	EPGN UNQ3072/PRO9904	Homo sapiens (Human)	154	FUNCTION: Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. {ECO:0000269|PubMed:15611079}.		angiogenesis [GO:0001525]; epidermal growth factor receptor signaling pathway [GO:0007173]; MAPK cascade [GO:0000165]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mitotic nuclear division [GO:0045840]	clathrin-coated endocytic vesicle membrane [GO:0030669]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	clathrin-coated endocytic vesicle membrane [GO:0030669]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; angiogenesis [GO:0001525]; epidermal growth factor receptor signaling pathway [GO:0007173]; MAPK cascade [GO:0000165]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mitotic nuclear division [GO:0045840]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted {ECO:0000305}.
Q6UWB1	reviewed	I27RA_HUMAN	Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)	IL27RA CRL1 TCCR WSX1 UNQ296/PRO336	Homo sapiens (Human)	636	FUNCTION: Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR (PubMed:19386761). Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. {ECO:0000269|PubMed:14764690, ECO:0000269|PubMed:19386761}.		cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of T cell extravasation [GO:2000408]; negative regulation of T-helper 17 type immune response [GO:2000317]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of type II interferon production [GO:0032729]; regulation of isotype switching to IgG isotypes [GO:0048302]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; interleukin-27 receptor activity [GO:0045509]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; interleukin-27 receptor activity [GO:0045509]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of T cell extravasation [GO:2000408]; negative regulation of T-helper 17 type immune response [GO:2000317]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of type II interferon production [GO:0032729]; regulation of isotype switching to IgG isotypes [GO:0048302]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q6UWB4	reviewed	PRS55_HUMAN	Serine protease 55 (EC 3.4.21.-) (Testis serine protease 1) (T-SP1)	PRSS55 TSP1 UNQ9391/PRO34284	Homo sapiens (Human)	352	FUNCTION: Probable serine protease, which plays a crucial role in the fertility of male mice including sperm migration and sperm-egg interaction. {ECO:0000250|UniProtKB:Q14BX2}.		binding of sperm to zona pellucida [GO:0007339]; flagellated sperm motility [GO:0030317]; proteolysis [GO:0006508]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	serine-type endopeptidase activity [GO:0004252]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; serine-type endopeptidase activity [GO:0004252]; binding of sperm to zona pellucida [GO:0007339]; flagellated sperm motility [GO:0030317]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:18844450}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q14BX2}. Cytoplasm, cytosol {ECO:0000269|PubMed:18844450}. Note=Mainly found in the membrane part of the cells and only in small amounts in the cytosol. {ECO:0000269|PubMed:18844450}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:18844450}. Note=Present primarily in the cytosol and only in minor amounts in the membrane fraction. {ECO:0000269|PubMed:18844450}.
Q6UWE0	reviewed	LRSM1_HUMAN	E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL)	LRSAM1 TAL UNQ6496/PRO21356	Homo sapiens (Human)	723	FUNCTION: E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322, ECO:0000269|PubMed:25484098}.		autophagy [GO:0006914]; negative regulation of endocytosis [GO:0045806]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of xenophagy [GO:1904417]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent endocytosis [GO:0070086]; viral budding [GO:0046755]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; autophagy [GO:0006914]; negative regulation of endocytosis [GO:0045806]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of xenophagy [GO:1904417]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent endocytosis [GO:0070086]; viral budding [GO:0046755]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:27615052}. Note=Displays a punctuate distribution and localizes to a submembranal ring (PubMed:15256501). Localizes to intracellular bacterial pathogens (PubMed:23245322). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322}.
Q6UWF3	reviewed	SCIMP_HUMAN	SLP adapter and CSK-interacting membrane protein (SLP65/SLP76, Csk-interacting membrane protein)	SCIMP C17orf87 UNQ5783/PRO16090	Homo sapiens (Human)	145	FUNCTION: Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed:21930792). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity). {ECO:0000250|UniProtKB:Q3UU41, ECO:0000269|PubMed:21930792}.		cellular response to molecule of fungal origin [GO:0071226]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of stress-activated MAPK cascade [GO:0032874]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]	filopodium [GO:0030175]; immunological synapse [GO:0001772]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; receptor complex [GO:0043235]; ruffle [GO:0001726]; tetraspanin-enriched microdomain [GO:0097197]; uropod membrane [GO:0031259]	molecular adaptor activity [GO:0060090]	filopodium [GO:0030175]; immunological synapse [GO:0001772]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; receptor complex [GO:0043235]; ruffle [GO:0001726]; tetraspanin-enriched microdomain [GO:0097197]; uropod membrane [GO:0031259]; molecular adaptor activity [GO:0060090]; cellular response to molecule of fungal origin [GO:0071226]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of stress-activated MAPK cascade [GO:0032874]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:21930792}; Lipid-anchor {ECO:0000269|PubMed:21930792}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q3UU41}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q3UU41}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q3UU41}. Note=Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs) (PubMed:21930792). Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen-presenting cells (APCs) and T-cells (PubMed:21930792). Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod (PubMed:21930792). Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:21930792). Localizes to phagosomes in dendritic cells after exposure to particulate beta-glucan (By similarity). {ECO:0000250|UniProtKB:Q3UU41, ECO:0000269|PubMed:21930792}.
Q6UWI2	reviewed	PARM1_HUMAN	Prostate androgen-regulated mucin-like protein 1 (PARM-1)	PARM1 UNQ1879/PRO4322	Homo sapiens (Human)	310	FUNCTION: May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. {ECO:0000250}.		positive regulation of telomerase activity [GO:0051973]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; positive regulation of telomerase activity [GO:0051973]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18027867}; Single-pass type I membrane protein {ECO:0000269|PubMed:18027867}. Golgi apparatus membrane {ECO:0000269|PubMed:18027867}; Single-pass type I membrane protein {ECO:0000269|PubMed:18027867}. Endosome membrane {ECO:0000269|PubMed:18027867}; Single-pass type I membrane protein {ECO:0000269|PubMed:18027867}.
Q6UWK7	reviewed	GP15L_HUMAN	Protein GPR15LG (Antimicrobial peptide with 57 amino acid residues) (AP-57) (Antimicrobial peptide-57) (Colon-derived SUSD2 binding factor) (CSBF) (Protein GPR15 ligand) (Protein GPR15L) (Secreted protein C10orf99)	GPR15LG C10orf99 GPR15L UNQ1833/PRO3446	Homo sapiens (Human)	81	FUNCTION: Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May regulate keratinocyte proliferation (PubMed:29872130). In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed:35704588). {ECO:0000269|PubMed:25351403, ECO:0000269|PubMed:28900043, ECO:0000269|PubMed:28936214, ECO:0000269|PubMed:29872130, ECO:0000269|PubMed:35704588}.; FUNCTION: Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus (PubMed:25585381). {ECO:0000269|PubMed:25585381}.		defense response to fungus [GO:0050832]; defense response to Gram-positive bacterium [GO:0050830]; G protein-coupled receptor signaling pathway [GO:0007186]; lymphocyte chemotaxis [GO:0048247]; mast cell degranulation [GO:0043303]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell division [GO:0051782]; regulation of keratinocyte proliferation [GO:0010837]; regulation of T cell migration [GO:2000404]; T cell homeostasis [GO:0043029]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	chemokine activity [GO:0008009]; G protein-coupled receptor binding [GO:0001664]; receptor ligand activity [GO:0048018]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; chemokine activity [GO:0008009]; G protein-coupled receptor binding [GO:0001664]; receptor ligand activity [GO:0048018]; defense response to fungus [GO:0050832]; defense response to Gram-positive bacterium [GO:0050830]; G protein-coupled receptor signaling pathway [GO:0007186]; lymphocyte chemotaxis [GO:0048247]; mast cell degranulation [GO:0043303]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell division [GO:0051782]; regulation of keratinocyte proliferation [GO:0010837]; regulation of T cell migration [GO:2000404]; T cell homeostasis [GO:0043029]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25351403, ECO:0000269|PubMed:25585381}.
Q6UWL6	reviewed	KIRR2_HUMAN	Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3)	KIRREL2 NEPH3 UNQ5827/PRO19646	Homo sapiens (Human)	708	FUNCTION: May regulate basal insulin secretion. {ECO:0000250|UniProtKB:Q7TSU7}.		cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; negative regulation of protein phosphorylation [GO:0001933]	cell-cell junction [GO:0005911]; membrane [GO:0016020]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057]	cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]	cell-cell junction [GO:0005911]; membrane [GO:0016020]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; negative regulation of protein phosphorylation [GO:0001933]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7TSU7}; Single-pass type I membrane protein {ECO:0000255}. Note=Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin. {ECO:0000250|UniProtKB:Q7TSU7}.
Q6UWN5	reviewed	LYPD5_HUMAN	Ly6/PLAUR domain-containing protein 5	LYPD5 UNQ1908/PRO4356	Homo sapiens (Human)	251				extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Q6UWP2	reviewed	DHR11_HUMAN	Dehydrogenase/reductase SDR family member 11 (17-beta-hydroxysteroid dehydrogenase) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (Short-chain dehydrogenase/reductase family 24C member 1)	DHRS11 SDR24C1 UNQ836/PRO1774	Homo sapiens (Human)	260	FUNCTION: Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. {ECO:0000269|PubMed:26920053}.		estrogen biosynthetic process [GO:0006703]; steroid biosynthetic process [GO:0006694]	extracellular region [GO:0005576]	17-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0072582]; 17-beta-ketosteroid reductase activity [GO:0072555]; 3-keto sterol reductase activity [GO:0000253]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; nucleotide binding [GO:0000166]	extracellular region [GO:0005576]; 17-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0072582]; 17-beta-ketosteroid reductase activity [GO:0072555]; 3-keto sterol reductase activity [GO:0000253]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; nucleotide binding [GO:0000166]; estrogen biosynthetic process [GO:0006703]; steroid biosynthetic process [GO:0006694]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UWP7	reviewed	LCLT1_HUMAN	Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (EC 2.3.1.51) (Acyl-CoA:lysocardiolipin acyltransferase 1)	LCLAT1 AGPAT8 ALCAT1 LYCAT UNQ1849/PRO3579	Homo sapiens (Human)	414	FUNCTION: Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:16620771). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (PubMed:19075029). Required for establishment of the hematopoietic and endothelial lineages (By similarity). {ECO:0000250|UniProtKB:Q3UN02, ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}.		cardiolipin acyl-chain remodeling [GO:0035965]; CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol acyl-chain remodeling [GO:0036149]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acyltransferase activity [GO:0016746]; O-acyltransferase activity [GO:0008374]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acyltransferase activity [GO:0016746]; O-acyltransferase activity [GO:0008374]; cardiolipin acyl-chain remodeling [GO:0035965]; CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol acyl-chain remodeling [GO:0036149]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19075029}; Multi-pass membrane protein {ECO:0000255}.
Q6UWR7	reviewed	ENPP6_HUMAN	Glycerophosphocholine cholinephosphodiesterase ENPP6 (GPC-Cpde) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) (E-NPP 6) (NPP-6)	ENPP6 UNQ1889/PRO4334	Homo sapiens (Human)	440	FUNCTION: Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:15788404). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity). {ECO:0000250|UniProtKB:Q8BGN3, ECO:0000269|PubMed:15788404}.		choline metabolic process [GO:0019695]; glycerophospholipid catabolic process [GO:0046475]; lipid metabolic process [GO:0006629]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	glycerophosphocholine cholinephosphodiesterase activity [GO:0047390]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; glycerophosphocholine cholinephosphodiesterase activity [GO:0047390]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081]; choline metabolic process [GO:0019695]; glycerophospholipid catabolic process [GO:0046475]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15788404}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:15788404}. Note=A small amount of the protein may be found in the extracellular milieu.
Q6UWU4	reviewed	CF089_HUMAN	Bombesin receptor-activated protein C6orf89 (Amfion)	C6orf89 BRAP UNQ177/PRO203	Homo sapiens (Human)	347	FUNCTION: Exhibits histone deacetylase (HDAC) enhancer properties (PubMed:23460338). May play a role in cell cycle progression and wound repair of bronchial epithelial cells (PubMed:21857995). {ECO:0000269|PubMed:21857995, ECO:0000269|PubMed:23460338}.	MISCELLANEOUS: Named amfion, after 'the 4 Amfion heroes in Greek mythology and their deeds in different locations within the mother land. {ECO:0000303|PubMed:23460338}.	chromatin remodeling [GO:0006338]; epithelial cell proliferation [GO:0050673]; positive regulation of cell cycle [GO:0045787]; wound healing [GO:0042060]	cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; midbody [GO:0030496]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; midbody [GO:0030496]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; chromatin remodeling [GO:0006338]; epithelial cell proliferation [GO:0050673]; positive regulation of cell cycle [GO:0045787]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:23460338}; Single-pass type II membrane protein {ECO:0000269|PubMed:23460338}. Midbody {ECO:0000269|PubMed:23460338}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane {ECO:0000269|PubMed:23460338}; Single-pass type II membrane protein {ECO:0000269|PubMed:23460338}. Midbody {ECO:0000269|PubMed:23460338}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:21857995}. Nucleus, nucleolus {ECO:0000269|PubMed:21857995, ECO:0000269|PubMed:23460338}. Note=Retained in nucleolar organiser regions (NORs) in mitotic cells (PubMed:23460338). {ECO:0000269|PubMed:23460338}.
Q6UWV6	reviewed	ENPP7_HUMAN	Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) (NPP-7) (EC 3.1.4.12) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase)	ENPP7 UNQ3077/PRO9912	Homo sapiens (Human)	458	FUNCTION: Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:12885774, PubMed:12671034, PubMed:15205117, PubMed:16255717, PubMed:28292932). Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation (PubMed:16255717, PubMed:12885774). Does not have nucleotide pyrophosphatase activity (PubMed:12885774). May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity). {ECO:0000250|UniProtKB:Q3TIW9, ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:12885774, ECO:0000269|PubMed:15205117, ECO:0000269|PubMed:16255717, ECO:0000269|PubMed:28292932}.	MISCELLANEOUS: Decreased levels of alkaline sphingomyelin phosphodiesterase may be associated with colon cancer. {ECO:0000303|PubMed:12671034, ECO:0000303|PubMed:15016655}.	fatty acid homeostasis [GO:0055089]; glycosphingolipid metabolic process [GO:0006687]; lipid digestion [GO:0044241]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of intestinal cholesterol absorption [GO:0045797]; positive regulation of sphingomyelin catabolic process [GO:2000755]; regulation of intestinal lipid absorption [GO:1904729]; sphingomyelin metabolic process [GO:0006684]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767]; zinc ion binding [GO:0008270]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767]; zinc ion binding [GO:0008270]; fatty acid homeostasis [GO:0055089]; glycosphingolipid metabolic process [GO:0006687]; lipid digestion [GO:0044241]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of intestinal cholesterol absorption [GO:0045797]; positive regulation of sphingomyelin catabolic process [GO:2000755]; regulation of intestinal lipid absorption [GO:1904729]; sphingomyelin metabolic process [GO:0006684]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:15205117}; Single-pass type I membrane protein {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:15205117}. Note=The catalytic domain is released into the extracellular medium when cells are treated with trypsin (PubMed:15205117). Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex (PubMed:12671034, PubMed:12885774). {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:12885774, ECO:0000269|PubMed:15205117}.
Q6UWW8	reviewed	EST3_HUMAN	Carboxylesterase 3 (EC 3.1.1.1) (Liver carboxylesterase 31 homolog)	CES3 UNQ869/PRO1887	Homo sapiens (Human)	571	FUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.		low-density lipoprotein particle clearance [GO:0034383]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]	carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]	cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; low-density lipoprotein particle clearance [GO:0034383]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250}.
Q6UWY0	reviewed	ARSK_HUMAN	Arylsulfatase K (ASK) (EC 3.1.6.1) (Glucuronate-2-sulfatase) (EC 3.1.6.18) (Telethon sulfatase)	ARSK TSULF UNQ630/PRO1246	Homo sapiens (Human)	536	FUNCTION: Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (PubMed:23986440). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (PubMed:28055182, PubMed:34916232). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (PubMed:28055182). {ECO:0000269|PubMed:23986440, ECO:0000269|PubMed:28055182, ECO:0000269|PubMed:34916232}.			endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; lysosome [GO:0005764]	arylsulfatase activity [GO:0004065]; glucuronate-2-sulfatase activity [GO:0015024]; metal ion binding [GO:0046872]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; lysosome [GO:0005764]; arylsulfatase activity [GO:0004065]; glucuronate-2-sulfatase activity [GO:0015024]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23986440}. Lysosome {ECO:0000269|PubMed:23986440}.
Q6UWY2	reviewed	PRS57_HUMAN	Serine protease 57 (EC 3.4.21.-) (Neutrophil serine protease 4) (NSP4) (Serine protease 1-like protein 1)	PRSS57 PRSSL1 UNQ782/PRO1599	Homo sapiens (Human)	283	FUNCTION: Serine protease that cleaves preferentially after Arg residues (PubMed:22474388, PubMed:23904161, PubMed:25156428). Can also cleave after citrulline (deimidated arginine) and methylarginine residues (PubMed:25156428). {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161, ECO:0000269|PubMed:25156428}.		proteolysis [GO:0006508]	azurophil granule lumen [GO:0035578]; extracellular space [GO:0005615]	heparin binding [GO:0008201]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	azurophil granule lumen [GO:0035578]; extracellular space [GO:0005615]; heparin binding [GO:0008201]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasmic granule lumen {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161}. Secreted {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161}. Note=Stored in cytoplasmic granules and secreted as active enzyme in response to stimulation of neutrophils. {ECO:0000269|PubMed:22474388}.
Q6UWZ7	reviewed	ABRX1_HUMAN	BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A)	ABRAXAS1 ABRA1 CCDC98 FAM175A UNQ496/PRO1013	Homo sapiens (Human)	409	FUNCTION: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:22357538, ECO:0000269|PubMed:26778126}.		attachment of spindle microtubules to kinetochore [GO:0008608]; chromatin organization [GO:0006325]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; mitotic spindle assembly [GO:0090307]; positive regulation of DNA repair [GO:0045739]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]	BRCA1-A complex [GO:0070531]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	microtubule binding [GO:0008017]; polyubiquitin modification-dependent protein binding [GO:0031593]	BRCA1-A complex [GO:0070531]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; microtubule binding [GO:0008017]; polyubiquitin modification-dependent protein binding [GO:0031593]; attachment of spindle microtubules to kinetochore [GO:0008608]; chromatin organization [GO:0006325]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; mitotic spindle assembly [GO:0090307]; positive regulation of DNA repair [GO:0045739]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000305}.
Q6UX01	reviewed	LMBRL_HUMAN	Protein LMBR1L (Limb region 1 protein homolog-like) (Lipocalin-1-interacting membrane receptor) (LIMR)	LMBR1L KIAA1174 LIMR UNQ458/PRO783	Homo sapiens (Human)	489	FUNCTION: Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685). {ECO:0000250|UniProtKB:Q9D1E5, ECO:0000269|PubMed:11287427, ECO:0000269|PubMed:12591932, ECO:0000269|PubMed:23964685}.		hematopoietic stem cell differentiation [GO:0060218]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165]; T cell apoptotic process [GO:0070231]; T cell differentiation [GO:0030217]; T cell proliferation [GO:0042098]; Wnt signaling pathway [GO:0016055]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; hematopoietic stem cell differentiation [GO:0060218]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165]; T cell apoptotic process [GO:0070231]; T cell differentiation [GO:0030217]; T cell proliferation [GO:0042098]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11287427, ECO:0000269|PubMed:17991420, ECO:0000269|PubMed:31073040}; Multi-pass membrane protein {ECO:0000269|PubMed:11287427}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:31073040}; Multi-pass membrane protein {ECO:0000255}.
Q6UX04	reviewed	CWC27_HUMAN	Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10)	CWC27 SDCCAG10 UNQ438/PRO871	Homo sapiens (Human)	472	FUNCTION: As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}.		mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; U2-type precatalytic spliceosome [GO:0071005]		catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; U2-type precatalytic spliceosome [GO:0071005]; mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:29360106}.
Q6UX06	reviewed	OLFM4_HUMAN	Olfactomedin-4 (OLM4) (Antiapoptotic protein GW112) (G-CSF-stimulated clone 1 protein) (hGC-1) (hOLfD)	OLFM4 GW112 UNQ362/PRO698	Homo sapiens (Human)	510	FUNCTION: May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. {ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:17270022, ECO:0000269|PubMed:20724538}.		cell adhesion [GO:0007155]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; signal transduction [GO:0007165]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intercellular bridge [GO:0045171]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	cadherin binding [GO:0045296]; structural molecule activity [GO:0005198]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intercellular bridge [GO:0045171]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; cadherin binding [GO:0045296]; structural molecule activity [GO:0005198]; cell adhesion [GO:0007155]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901, PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). {ECO:0000269|PubMed:15059901, ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:20724538}.
Q6UX15	reviewed	LAYN_HUMAN	Layilin	LAYN UNQ208/PRO234	Homo sapiens (Human)	382	FUNCTION: Receptor for hyaluronate. {ECO:0000269|PubMed:11294894}.			cell surface [GO:0009986]; focal adhesion [GO:0005925]; membrane [GO:0016020]; ruffle [GO:0001726]	carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540]	cell surface [GO:0009986]; focal adhesion [GO:0005925]; membrane [GO:0016020]; ruffle [GO:0001726]; carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with TLN1 at the membrane ruffles. {ECO:0000250}.
Q6UX27	reviewed	VSTM1_HUMAN	V-set and transmembrane domain-containing protein 1 (Signal inhibitory receptor on leukocytes-1) (SIRL-1)	VSTM1 UNQ3033/PRO9835	Homo sapiens (Human)	236	FUNCTION: [Isoform 2]: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).; FUNCTION: [Isoform 1]: Inhibitory immune receptor involved in the regulation of phagocytes.	MISCELLANEOUS: [Isoform 2]: Mainly detected in immune tissues and cells. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	immune system process [GO:0002376]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; immune system process [GO:0002376]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:22960280}.
Q6UX34	reviewed	SNORC_HUMAN	Protein SNORC (Secondary ossification center-associated regulator of chondrocyte maturation protein)	SNORC C2orf82 UNQ830/PRO1757	Homo sapiens (Human)	121	FUNCTION: Plays a role in the regulation of chondrocyte maturation and postnatal endochondral ossification. May inhibit cell growth stimulation induced by FGF2. {ECO:0000250|UniProtKB:Q9CXL7}.		cartilage development [GO:0051216]	cell periphery [GO:0071944]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]		cell periphery [GO:0071944]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; cartilage development [GO:0051216]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:Q9CXL7}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9CXL7}. Note=Appears as reticular-like structures throughout the cytoplasm and adjacent to the plasma membrane. In proliferation and hypertrophic chondrocytes, detected intracellulary and in the pericellular extracellular matrix. In primary spongiosa, detected only in the extracellular matrix. {ECO:0000250|UniProtKB:Q9CXL7}.
Q6UX39	reviewed	AMTN_HUMAN	Amelotin	AMTN UNQ689/PRO1329	Homo sapiens (Human)	209	FUNCTION: Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. {ECO:0000269|PubMed:25407797}.		biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of enamel mineralization [GO:0070175]	basement membrane [GO:0005604]; cell-cell junction [GO:0005911]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]		basement membrane [GO:0005604]; cell-cell junction [GO:0005911]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of enamel mineralization [GO:0070175]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9D3J8}.
Q6UX40	reviewed	TM107_HUMAN	Transmembrane protein 107	TMEM107 DC20 UNQ638/PRO1268	Homo sapiens (Human)	140	FUNCTION: Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26518474). {ECO:0000250|UniProtKB:Q9CPV0, ECO:0000269|PubMed:26518474}.		cilium assembly [GO:0060271]; craniofacial suture morphogenesis [GO:0097094]; detection of nodal flow [GO:0003127]; embryonic digit morphogenesis [GO:0042733]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]; regulation of gene expression [GO:0010468]; roof of mouth development [GO:0060021]	ciliary transition zone [GO:0035869]; membrane [GO:0016020]; MKS complex [GO:0036038]		ciliary transition zone [GO:0035869]; membrane [GO:0016020]; MKS complex [GO:0036038]; cilium assembly [GO:0060271]; craniofacial suture morphogenesis [GO:0097094]; detection of nodal flow [GO:0003127]; embryonic digit morphogenesis [GO:0042733]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]; regulation of gene expression [GO:0010468]; roof of mouth development [GO:0060021]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:26595381}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000269|PubMed:26595381}.
Q6UX41	reviewed	BTNL8_HUMAN	Butyrophilin-like protein 8	BTNL8 UNQ702/PRO1347	Homo sapiens (Human)	500	FUNCTION: May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production. {ECO:0000269|PubMed:24036152}.		adaptive immune response [GO:0002250]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; signaling receptor binding [GO:0005102]; adaptive immune response [GO:0002250]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q6UX46	reviewed	ALKL2_HUMAN	ALK and LTK ligand 2 (Augmentor alpha) (AUG-alpha)	ALKAL2 FAM150B UNQ542/PRO1097	Homo sapiens (Human)	152	FUNCTION: Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation (PubMed:26418745, PubMed:26630010, PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). Cytokine-binding is sufficient to activate LTK (PubMed:34646012). In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK (PubMed:34646012). Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure (PubMed:34646012, PubMed:34819673). {ECO:0000269|PubMed:26418745, ECO:0000269|PubMed:26630010, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}.		positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of ERK5 cascade [GO:0070378]; positive regulation of neuron projection development [GO:0010976]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of ERK5 cascade [GO:0070378]; positive regulation of neuron projection development [GO:0010976]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30061385}. Cell membrane {ECO:0000269|PubMed:34819673}. Note=Following interaction with receptor tyrosine kinase ALK, associates with the cell membrane, membrane-binding is required to activate ALK. {ECO:0000269|PubMed:34819673}.
Q6UX65	reviewed	DRAM2_HUMAN	DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77)	DRAM2 TMEM77 PSEC0031 UNQ154/PRO180	Homo sapiens (Human)	266	FUNCTION: Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1. {ECO:0000269|PubMed:19895784, ECO:0000269|PubMed:25983245}.		apoptotic process [GO:0006915]; autophagy [GO:0006914]; photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; photoreceptor inner segment [GO:0001917]		apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; photoreceptor inner segment [GO:0001917]; apoptotic process [GO:0006915]; autophagy [GO:0006914]; photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:19556885, ECO:0000269|PubMed:19895784}; Multi-pass membrane protein {ECO:0000269|PubMed:19556885, ECO:0000269|PubMed:19895784}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9CR48}. Apical cell membrane {ECO:0000250|UniProtKB:Q9CR48}. Note=Localized to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells. {ECO:0000250|UniProtKB:Q9CR48}.
Q6UX71	reviewed	PXDC2_HUMAN	Plexin domain-containing protein 2 (Tumor endothelial marker 7-related protein)	PLXDC2 TEM7R UNQ2514/PRO6003	Homo sapiens (Human)	529	FUNCTION: May play a role in tumor angiogenesis. {ECO:0000269|PubMed:11559528}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6UX98	reviewed	ZDH24_HUMAN	Probable palmitoyltransferase ZDHHC24 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 24)	ZDHHC24 UNQ2528/PRO6027	Homo sapiens (Human)	284	FUNCTION: Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. {ECO:0000305}.		protein targeting to membrane [GO:0006612]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q6UXB2	reviewed	CXL17_HUMAN	C-X-C motif chemokine 17 (6-Cys CXCL17) (Dendritic cell and monocyte chemokine-like protein) (DMC) (VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17]	CXCL17 VCC1 UNQ473/PRO842	Homo sapiens (Human)	119	FUNCTION: Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203). {ECO:0000269|PubMed:16455961, ECO:0000269|PubMed:16989774, ECO:0000269|PubMed:17307946, ECO:0000269|PubMed:23115081, ECO:0000269|PubMed:25411203}.; FUNCTION: [4-Cys CXCL17]: Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17. {ECO:0000269|PubMed:23115081}.		angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; macrophage chemotaxis [GO:0048246]; negative regulation of inflammatory response [GO:0050728]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of vascular endothelial growth factor production [GO:0010575]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; macrophage chemotaxis [GO:0048246]; negative regulation of inflammatory response [GO:0050728]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of vascular endothelial growth factor production [GO:0010575]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23115081}.
Q6UXB4	reviewed	CLC4G_HUMAN	C-type lectin domain family 4 member G (Liver and lymph node sinusoidal endothelial cell C-type lectin) (LSECtin)	CLEC4G UNQ431/PRO792	Homo sapiens (Human)	293	FUNCTION: Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro. {ECO:0000269|PubMed:14711836}.; FUNCTION: (Microbial infection) Acts as a receptor for Japanese encephalitis virus. {ECO:0000269|PubMed:24623090}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus. {ECO:0000269|PubMed:16051304}.; FUNCTION: (Microbial infection) Acts as a receptor for SARS-CoV. {ECO:0000269|PubMed:16051304}.; FUNCTION: (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088). {ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088}.		alpha-beta T cell proliferation [GO:0046633]; immature T cell proliferation in thymus [GO:0033080]; immune response [GO:0006955]; negative regulation of alpha-beta T cell proliferation [GO:0046642]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of T cell mediated immunity [GO:0002710]; positive regulation of viral life cycle [GO:1903902]; T cell mediated immunity [GO:0002456]; viral entry into host cell [GO:0046718]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; carbohydrate derivative binding [GO:0097367]; fructose binding [GO:0070061]; glycosylated region protein binding [GO:0140081]; mannose binding [GO:0005537]; polysaccharide binding [GO:0030247]; virus coreceptor activity [GO:0120274]; virus receptor activity [GO:0001618]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; carbohydrate derivative binding [GO:0097367]; fructose binding [GO:0070061]; glycosylated region protein binding [GO:0140081]; mannose binding [GO:0005537]; polysaccharide binding [GO:0030247]; virus coreceptor activity [GO:0120274]; virus receptor activity [GO:0001618]; alpha-beta T cell proliferation [GO:0046633]; immature T cell proliferation in thymus [GO:0033080]; immune response [GO:0006955]; negative regulation of alpha-beta T cell proliferation [GO:0046642]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of T cell mediated immunity [GO:0002710]; positive regulation of viral life cycle [GO:1903902]; T cell mediated immunity [GO:0002456]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein {ECO:0000269|PubMed:14711836}.
Q6UXB8	reviewed	PI16_HUMAN	Peptidase inhibitor 16 (PI-16) (Cysteine-rich secretory protein 9) (CRISP-9) (PSP94-binding protein) (CD antigen CD364)	PI16 CRISP9 PSPBP PSEC0164 UNQ289/PRO328	Homo sapiens (Human)	463	FUNCTION: May inhibit cardiomyocyte growth. {ECO:0000250|UniProtKB:Q9ET66}.	MISCELLANEOUS: May serve as a marker following prostatectomy for prostate cancer.	negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]	extracellular space [GO:0005615]	peptidase inhibitor activity [GO:0030414]	extracellular space [GO:0005615]; peptidase inhibitor activity [GO:0030414]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15344909, ECO:0000269|PubMed:17062675, ECO:0000269|PubMed:22171320}.
Q6UXD5	reviewed	SE6L2_HUMAN	Seizure 6-like protein 2	SEZ6L2 PSK UNQ1903/PRO4349	Homo sapiens (Human)	910	FUNCTION: May contribute to specialized endoplasmic reticulum functions in neurons. {ECO:0000250}.	MISCELLANEOUS: May serve as a prognostic marker for lung cancers.	regulation of protein kinase C signaling [GO:0090036]; synapse maturation [GO:0060074]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; regulation of protein kinase C signaling [GO:0090036]; synapse maturation [GO:0060074]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16863507}; Single-pass type I membrane protein {ECO:0000269|PubMed:16863507}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Detected on cell surface of lung-cancer.
Q6UXF1	reviewed	TM108_HUMAN	Transmembrane protein 108 (Retrolinkin)	TMEM108 KIAA1690 RTLN UNQ1875/PRO4318	Homo sapiens (Human)	575	FUNCTION: Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. {ECO:0000250|UniProtKB:Q8BHE4}.		cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; dendrite extension [GO:0097484]; dentate gyrus development [GO:0021542]; modulation of excitatory postsynaptic potential [GO:0098815]; neuron projection development [GO:0031175]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; postsynaptic density organization [GO:0097106]; receptor-mediated endocytosis [GO:0006898]; retrograde axonal transport [GO:0008090]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; dendrite [GO:0030425]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; postsynaptic density [GO:0014069]; somatodendritic compartment [GO:0036477]		axon [GO:0030424]; axon cytoplasm [GO:1904115]; dendrite [GO:0030425]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; postsynaptic density [GO:0014069]; somatodendritic compartment [GO:0036477]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; dendrite extension [GO:0097484]; dentate gyrus development [GO:0021542]; modulation of excitatory postsynaptic potential [GO:0098815]; neuron projection development [GO:0031175]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; postsynaptic density organization [GO:0097106]; receptor-mediated endocytosis [GO:0006898]; retrograde axonal transport [GO:0008090]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8BHE4}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000250|UniProtKB:Q8BHE4}. Endosome membrane {ECO:0000250|UniProtKB:Q8BHE4}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BHE4}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHE4}. Early endosome {ECO:0000250|UniProtKB:Q8BHE4}.
Q6UXG2	reviewed	ELAP1_HUMAN	Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Estrogen-induced gene 121 protein)	ELAPOR1 EIG121 KIAA1324 UNQ2426/PRO4985	Homo sapiens (Human)	1013	FUNCTION: May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway (PubMed:21072319). May play a role in apoptosis and cell proliferation through its interaction with HSPA5 (PubMed:26045166). {ECO:0000269|PubMed:21072319, ECO:0000269|PubMed:26045166}.		autophagosome assembly [GO:0000045]; cellular response to starvation [GO:0009267]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of vacuole organization [GO:0044090]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	RNA binding [GO:0003723]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]; autophagosome assembly [GO:0000045]; cellular response to starvation [GO:0009267]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of vacuole organization [GO:0044090]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21072319, ECO:0000269|PubMed:26045166}; Single-pass type I membrane protein {ECO:0000269|PubMed:21072319}. Late endosome membrane {ECO:0000269|PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269|PubMed:21072319}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269|PubMed:21072319}. Lysosome membrane {ECO:0000269|PubMed:21072319}; Single-pass membrane protein {ECO:0000269|PubMed:21072319}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:26045166}; Single-pass type I membrane protein {ECO:0000269|PubMed:21072319}.
Q6UXG3	reviewed	CLM9_HUMAN	CMRF35-like molecule 9 (CLM-9) (CD300 antigen-like family member G) (Triggering receptor expressed on myeloid cells 4) (TREM-4) (CD antigen CD300g)	CD300LG CLM9 TREM4 UNQ422/PRO846	Homo sapiens (Human)	332	FUNCTION: Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity). {ECO:0000250}.		immune system process [GO:0002376]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; immune system process [GO:0002376]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q1ERP8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q1ERP8}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q1ERP8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q1ERP8}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q1ERP8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q1ERP8}. Note=Transcytoses across the cytoplasm. {ECO:0000250|UniProtKB:Q1ERP8}.
Q6UXG8	reviewed	BTNL9_HUMAN	Butyrophilin-like protein 9	BTNL9 UNQ1900/PRO4346	Homo sapiens (Human)	535			regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; signaling receptor binding [GO:0005102]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q6UXH0	reviewed	ANGL8_HUMAN	Angiopoietin-like protein 8 (Betatrophin) (Lipasin) (Refeeding-induced fat and liver protein)	ANGPTL8 C19orf80 RIFL UNQ599/PRO1185	Homo sapiens (Human)	198	FUNCTION: Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity). {ECO:0000250|UniProtKB:Q8R1L8, ECO:0000269|PubMed:22569073, ECO:0000269|PubMed:22809513, ECO:0000269|PubMed:23150577}.		cell maturation [GO:0048469]; cellular lipid metabolic process [GO:0044255]; fat cell differentiation [GO:0045444]; positive regulation of protein processing [GO:0010954]; regulation of lipid metabolic process [GO:0019216]; regulation of lipoprotein metabolic process [GO:0050746]; triglyceride homeostasis [GO:0070328]	extracellular region [GO:0005576]	hormone activity [GO:0005179]	extracellular region [GO:0005576]; hormone activity [GO:0005179]; cell maturation [GO:0048469]; cellular lipid metabolic process [GO:0044255]; fat cell differentiation [GO:0045444]; positive regulation of protein processing [GO:0010954]; regulation of lipid metabolic process [GO:0019216]; regulation of lipoprotein metabolic process [GO:0050746]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23150577}.
Q6UXH1	reviewed	CREL2_HUMAN	Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2)	CRELD2 UNQ185/PRO211	Homo sapiens (Human)	353	FUNCTION: Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698). {ECO:0000250|UniProtKB:Q9CYA0, ECO:0000269|PubMed:16238698}.	MISCELLANEOUS: [Isoform 3]: Minor isoform. {ECO:0000305}.		endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]	calcium ion binding [GO:0005509]; protein disulfide isomerase activity [GO:0003756]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; calcium ion binding [GO:0005509]; protein disulfide isomerase activity [GO:0003756]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:16238698}.
Q6UXH8	reviewed	CCBE1_HUMAN	Collagen and calcium-binding EGF domain-containing protein 1 (Full of fluid protein homolog)	CCBE1 KIAA1983 UNQ1921/PRO4395	Homo sapiens (Human)	406	FUNCTION: Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. {ECO:0000269|PubMed:19935664}.		lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell migration [GO:1904977]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of lymphangiogenesis [GO:1901492]; positive regulation of protein processing [GO:0010954]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; respiratory system process [GO:0003016]; sprouting angiogenesis [GO:0002040]; venous blood vessel morphogenesis [GO:0048845]	collagen trimer [GO:0005581]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; protease binding [GO:0002020]	collagen trimer [GO:0005581]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; protease binding [GO:0002020]; lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell migration [GO:1904977]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of lymphangiogenesis [GO:1901492]; positive regulation of protein processing [GO:0010954]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; respiratory system process [GO:0003016]; sprouting angiogenesis [GO:0002040]; venous blood vessel morphogenesis [GO:0048845]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313}.
Q6UXI9	reviewed	NPNT_HUMAN	Nephronectin (Preosteoblast EGF-like repeat protein with MAM domain) (Protein EGFL6-like)	NPNT EGFL6L POEM UNQ295/PRO334	Homo sapiens (Human)	565	FUNCTION: Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity). {ECO:0000250}.		branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cellular response to tumor necrosis factor [GO:0071356]; establishment of protein localization [GO:0045184]; extracellular matrix organization [GO:0030198]; pilomotor reflex [GO:0097195]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; smooth muscle cell differentiation [GO:0051145]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; smooth muscle contractile fiber [GO:0030485]	calcium ion binding [GO:0005509]; integrin binding [GO:0005178]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; smooth muscle contractile fiber [GO:0030485]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cellular response to tumor necrosis factor [GO:0071356]; establishment of protein localization [GO:0045184]; extracellular matrix organization [GO:0030198]; pilomotor reflex [GO:0097195]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; smooth muscle cell differentiation [GO:0051145]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Trapped on the cell surface or in the extracellular matrix. {ECO:0000250}.
Q6UXK2	reviewed	ISLR2_HUMAN	Immunoglobulin superfamily containing leucine-rich repeat protein 2 (Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein)	ISLR2 KIAA1465 LINX UNQ1885/PRO4329	Homo sapiens (Human)	745	FUNCTION: Required for axon extension during neural development. {ECO:0000250}.		nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773]	cell surface [GO:0009986]; plasma membrane [GO:0005886]		cell surface [GO:0009986]; plasma membrane [GO:0005886]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q6UXL0	reviewed	I20RB_HUMAN	Interleukin-20 receptor subunit beta (IL-20 receptor subunit beta) (IL-20R-beta) (IL-20RB) (Fibronectin type III domain containing 6) (FNDC6) (IL-20R2)	IL20RB DIRS1 UNQ557/PRO1114	Homo sapiens (Human)	311	FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.		cytokine-mediated signaling pathway [GO:0019221]; homeostasis of number of cells within a tissue [GO:0048873]; immune response-inhibiting signal transduction [GO:0002765]; inflammatory response to antigenic stimulus [GO:0002437]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type II interferon production [GO:0032689]; negative regulation of type IV hypersensitivity [GO:0001808]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-4 production [GO:0032753]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]	plasma membrane [GO:0005886]	cytokine receptor activity [GO:0004896]; interleukin-20 binding [GO:0042015]	plasma membrane [GO:0005886]; cytokine receptor activity [GO:0004896]; interleukin-20 binding [GO:0042015]; cytokine-mediated signaling pathway [GO:0019221]; homeostasis of number of cells within a tissue [GO:0048873]; immune response-inhibiting signal transduction [GO:0002765]; inflammatory response to antigenic stimulus [GO:0002437]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type II interferon production [GO:0032689]; negative regulation of type IV hypersensitivity [GO:0001808]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-4 production [GO:0032753]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q6UXN8	reviewed	CLC9A_HUMAN	C-type lectin domain family 9 member A (CD antigen CD370)	CLEC9A UNQ9341/PRO34046	Homo sapiens (Human)	241	FUNCTION: Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. {ECO:0000269|PubMed:18497879, ECO:0000269|PubMed:22483802}.		positive regulation of cytokine production [GO:0001819]; receptor-mediated endocytosis [GO:0006898]	cell surface [GO:0009986]; membrane [GO:0016020]	carbohydrate binding [GO:0030246]	cell surface [GO:0009986]; membrane [GO:0016020]; carbohydrate binding [GO:0030246]; positive regulation of cytokine production [GO:0001819]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:18408006}; Single-pass type II membrane protein {ECO:0000269|PubMed:18408006}.
Q6UXN9	reviewed	WDR82_HUMAN	WD repeat-containing protein 82	WDR82 SWD2 TMEM113 WDR82A UNQ9342/PRO34047	Homo sapiens (Human)	313	FUNCTION: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes (PubMed:17998332, PubMed:18838538, PubMed:20516061). Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (PubMed:17998332, PubMed:18838538). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33913806, PubMed:33767452). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452). {ECO:0000269|PubMed:17998332, ECO:0000269|PubMed:18838538, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}.		DNA-templated transcription termination [GO:0006353]; lncRNA catabolic process [GO:0110064]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of lncRNA transcription [GO:0140744]; nuclear RNA surveillance [GO:0071027]	chromatin [GO:0000785]; histone methyltransferase complex [GO:0035097]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PTW/PP1 phosphatase complex [GO:0072357]; Set1C/COMPASS complex [GO:0048188]	chromatin binding [GO:0003682]	chromatin [GO:0000785]; histone methyltransferase complex [GO:0035097]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PTW/PP1 phosphatase complex [GO:0072357]; Set1C/COMPASS complex [GO:0048188]; chromatin binding [GO:0003682]; DNA-templated transcription termination [GO:0006353]; lncRNA catabolic process [GO:0110064]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of lncRNA transcription [GO:0140744]; nuclear RNA surveillance [GO:0071027]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16253997, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:20516061}. Chromosome {ECO:0000250|UniProtKB:Q8BFQ4}. Note=Associates with chromatin (PubMed:20516061). Recruited at sites of high RNA polymerase II occupancy (By similarity). {ECO:0000250|UniProtKB:Q8BFQ4, ECO:0000269|PubMed:20516061}.
Q6UXS9	reviewed	CASPC_HUMAN	Inactive caspase-12 (CASP-12)	CASP12 UNQ9415/PRO34398	Homo sapiens (Human)	341	FUNCTION: May function as a negative regulator of inflammatory responses and innate immunity. May reduce cytokine release in response to bacterial lipopolysaccharide during infection. Reduces activation of NF-kappa-B in response to TNF (PubMed:15129283). May lack protease activity (Probable). {ECO:0000269|PubMed:15129283, ECO:0000305|PubMed:12054529}.		proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]	cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	
Q6UXT8	reviewed	ALKL1_HUMAN	ALK and LTK ligand 1 (Augmentor beta) (AUG-beta)	ALKAL1 FAM150A UNQ9433/PRO34745	Homo sapiens (Human)	129	FUNCTION: Cytokine that acts as a physiological ligand for receptor tyrosine kinase LTK, leading to its activation (PubMed:25331893, PubMed:26418745, PubMed:26630010, PubMed:34646012, PubMed:34819673). Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation (PubMed:34646012, PubMed:34819673). In contrast to ALKAL2, does not act as a potent physiological ligand for ALK (PubMed:26418745, PubMed:34646012). {ECO:0000269|PubMed:25331893, ECO:0000269|PubMed:26418745, ECO:0000269|PubMed:26630010, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}.		positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of ERK5 cascade [GO:0070378]; positive regulation of neuron projection development [GO:0010976]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of ERK5 cascade [GO:0070378]; positive regulation of neuron projection development [GO:0010976]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UX46}. Cell membrane {ECO:0000305|PubMed:34646012}. Note=Following interaction with receptor tyrosine kinase LTK, associates with the cell membrane, membrane-binding is required to activate LTK. {ECO:0000250|UniProtKB:Q6UX46}.
Q6UXV0	reviewed	GFRAL_HUMAN	GDNF family receptor alpha-like	GFRAL C6orf144 UNQ9356/PRO34128	Homo sapiens (Human)	394	FUNCTION: Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. {ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886}.		glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; reduction of food intake in response to dietary excess [GO:0002023]; stress-activated protein kinase signaling cascade [GO:0031098]	actin cytoskeleton [GO:0015629]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	glial cell-derived neurotrophic factor receptor activity [GO:0016167]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor activity [GO:0038023]	actin cytoskeleton [GO:0015629]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; glial cell-derived neurotrophic factor receptor activity [GO:0016167]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor activity [GO:0038023]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; reduction of food intake in response to dietary excess [GO:0002023]; stress-activated protein kinase signaling cascade [GO:0031098]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28953886}; Single-pass membrane protein {ECO:0000269|PubMed:28953886}; Extracellular side {ECO:0000269|PubMed:28953886}.
Q6UXV4	reviewed	MIC27_HUMAN	MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A)	APOOL CXorf33 FAM121A MIC27 UNQ8193/PRO23204	Homo sapiens (Human)	268	FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979). {ECO:0000269|PubMed:23704930, ECO:0000269|PubMed:25764979}.		cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]	extracellular region [GO:0005576]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; platelet alpha granule lumen [GO:0031093]; SAM complex [GO:0001401]		extracellular region [GO:0005576]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; platelet alpha granule lumen [GO:0031093]; SAM complex [GO:0001401]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:23704930, ECO:0000269|PubMed:25764979}; Multi-pass membrane protein {ECO:0000269|PubMed:23704930}. Mitochondrion {ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:25997101}.
Q6UXX9	reviewed	RSPO2_HUMAN	R-spondin-2 (Roof plate-specific spondin-2) (hRspo2)	RSPO2 UNQ9384/PRO34209	Homo sapiens (Human)	243	FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21909076, PubMed:21727895, PubMed:22615920). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720). {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:29769720}.		bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; dopaminergic neuron differentiation [GO:0071542]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; limb development [GO:0060173]; lung growth [GO:0060437]; negative regulation of odontogenesis of dentin-containing tooth [GO:0042489]; osteoblast differentiation [GO:0001649]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway [GO:0030177]; trachea cartilage morphogenesis [GO:0060535]	cell surface [GO:0009986]; extracellular region [GO:0005576]	heparin binding [GO:0008201]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102]; bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; dopaminergic neuron differentiation [GO:0071542]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; limb development [GO:0060173]; lung growth [GO:0060437]; negative regulation of odontogenesis of dentin-containing tooth [GO:0042489]; osteoblast differentiation [GO:0001649]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway [GO:0030177]; trachea cartilage morphogenesis [GO:0060535]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8BFU0}.
Q6UXY1	reviewed	BI2L2_HUMAN	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar)	BAIAP2L2 UNQ9336/PRO34007	Homo sapiens (Human)	529	FUNCTION: Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}.		actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; membrane organization [GO:0061024]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838]	cell-cell contact zone [GO:0044291]; clathrin complex [GO:0071439]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]	phospholipid binding [GO:0005543]	cell-cell contact zone [GO:0044291]; clathrin complex [GO:0071439]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; phospholipid binding [GO:0005543]; actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; membrane organization [GO:0061024]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21743456}; Peripheral membrane protein {ECO:0000269|PubMed:21743456}. Cell junction {ECO:0000269|PubMed:21743456}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:21743456}. Note=Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts.
Q6UXZ0	reviewed	TMIG1_HUMAN	Transmembrane and immunoglobulin domain-containing protein 1	TMIGD1 TMIGD UNQ9372/PRO34164	Homo sapiens (Human)	262	FUNCTION: May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival. {ECO:0000269|PubMed:26342724}.		brush border assembly [GO:1904970]; cell aggregation [GO:0098743]; cell migration [GO:0016477]; cell-cell junction organization [GO:0045216]; cellular response to hydroperoxide [GO:0071447]; intestinal epithelial cell maturation [GO:0060574]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell proliferation [GO:0050680]; protein localization [GO:0008104]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of membrane permeability [GO:0090559]; response to nutrient [GO:0007584]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	cell-cell adhesion mediator activity [GO:0098632]; protein homodimerization activity [GO:0042803]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; cell-cell adhesion mediator activity [GO:0098632]; protein homodimerization activity [GO:0042803]; brush border assembly [GO:1904970]; cell aggregation [GO:0098743]; cell migration [GO:0016477]; cell-cell junction organization [GO:0045216]; cellular response to hydroperoxide [GO:0071447]; intestinal epithelial cell maturation [GO:0060574]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell proliferation [GO:0050680]; protein localization [GO:0008104]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of membrane permeability [GO:0090559]; response to nutrient [GO:0007584]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26342724}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:26342724}.
Q6UXZ3	reviewed	CLM5_HUMAN	CMRF35-like molecule 5 (CLM-5) (CD300 antigen-like family member D) (CMRF35-A4) (CD antigen CD300d)	CD300LD CD300D CMRF35A4 UNQ9218/PRO28686	Homo sapiens (Human)	194			immune system process [GO:0002376]	plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; immune system process [GO:0002376]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22291008}; Single-pass type I membrane protein {ECO:0000269|PubMed:22291008}. Note=Cell surface localization requires the ITAM-bearing Fc receptor FCER1G to overcome ER retention.
Q6UXZ4	reviewed	UNC5D_HUMAN	Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D)	UNC5D KIAA1777 UNC5H4 UNQ6012/PRO34692	Homo sapiens (Human)	953	FUNCTION: Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity). {ECO:0000250|UniProtKB:Q8K1S2, ECO:0000305|PubMed:24519068, ECO:0000305|PubMed:24691657}.		apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; pyramidal neuron differentiation [GO:0021859]; regulation of neuron migration [GO:2001222]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	netrin receptor activity [GO:0005042]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; netrin receptor activity [GO:0005042]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; pyramidal neuron differentiation [GO:0021859]; regulation of neuron migration [GO:2001222]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26235030}; Single-pass type I membrane protein {ECO:0000305}.
Q6UY09	reviewed	CEA20_HUMAN	Carcinoembryonic antigen-related cell adhesion molecule 20	CEACAM20 UNQ9366/PRO34155	Homo sapiens (Human)	596	FUNCTION: Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response. {ECO:0000250|UniProtKB:Q9D2Z1}.		immune system process [GO:0002376]; positive regulation of cytokine production [GO:0001819]; regulation of immune system process [GO:0002682]; response to bacterium [GO:0009617]; signal transduction [GO:0007165]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	protein tyrosine kinase binding [GO:1990782]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; protein tyrosine kinase binding [GO:1990782]; immune system process [GO:0002376]; positive regulation of cytokine production [GO:0001819]; regulation of immune system process [GO:0002682]; response to bacterium [GO:0009617]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell projection, microvillus membrane {ECO:0000250|UniProtKB:Q9D2Z1}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D2Z1}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with PTPRH and CEACAM1 at the apical brush border of intestinal cells.
Q6UY14	reviewed	ATL4_HUMAN	ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1)	ADAMTSL4 TSRC1 PP1396 UNQ2803/PRO34012	Homo sapiens (Human)	1074	FUNCTION: Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. {ECO:0000269|PubMed:16364318, ECO:0000269|PubMed:21989719}.		apoptotic process [GO:0006915]; epithelial cell development [GO:0002064]; extracellular matrix organization [GO:0030198]; pigment cell development [GO:0070285]; positive regulation of apoptotic process [GO:0043065]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614]	identical protein binding [GO:0042802]; protease binding [GO:0002020]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; apoptotic process [GO:0006915]; epithelial cell development [GO:0002064]; extracellular matrix organization [GO:0030198]; pigment cell development [GO:0070285]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:21989719}. Note=Colocalizes with FMN1 microfibrils in the eye ECM.
Q6V0I7	reviewed	FAT4_HUMAN	Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J)	FAT4 CDHF14 FATJ Nbla00548	Homo sapiens (Human)	4981	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). {ECO:0000250}.		cell-cell adhesion [GO:0098609]; cerebral cortex development [GO:0021987]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neurogenesis [GO:0022008]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell-cell adhesion [GO:0098609]; cerebral cortex development [GO:0021987]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neurogenesis [GO:0022008]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In the kidney, localizes to primary cilia. {ECO:0000250}.
Q6V0L0	reviewed	CP26C_HUMAN	Cytochrome P450 26C1 (CYP26C1) (EC 1.14.14.1)	CYP26C1	Homo sapiens (Human)	522	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed:14532297). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the oxidation of atRA primarily at C-4 (PubMed:14532297). Oxidation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination, thereby contributes to the regulation of atRA homeostasis and signaling (Probable). Able to metabolize other RAs such as 9-cis with high efficiency (PubMed:14532297). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). Shares sequence similarity with other CYP26 family members, but has higher affinity to 9-cis-RA and is much less sensitive to the inhibitory effects of ketoconazole (PubMed:14532297). In cooperation with Cyp26a1, contributes to the CNS patterning and the development of regions of higher visual acuity (By similarity). {ECO:0000250|UniProtKB:B2RXA7, ECO:0000269|PubMed:14532297, ECO:0000305|PubMed:14532297}.		anterior/posterior pattern specification [GO:0009952]; central nervous system development [GO:0007417]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; neural crest cell development [GO:0014032]; organelle fusion [GO:0048284]; retinoic acid catabolic process [GO:0034653]; sterol metabolic process [GO:0016125]; vitamin metabolic process [GO:0006766]	endoplasmic reticulum membrane [GO:0005789]	aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]	endoplasmic reticulum membrane [GO:0005789]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]; anterior/posterior pattern specification [GO:0009952]; central nervous system development [GO:0007417]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; neural crest cell development [GO:0014032]; organelle fusion [GO:0048284]; retinoic acid catabolic process [GO:0034653]; sterol metabolic process [GO:0016125]; vitamin metabolic process [GO:0006766]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6V1X1	reviewed	DPP8_HUMAN	Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8)	DPP8 DPRP1 MSTP097 MSTP135 MSTP141	Homo sapiens (Human)	898	FUNCTION: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:32796818). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:34019797, PubMed:33731929, PubMed:33731932). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity). {ECO:0000250|UniProtKB:Q86TI2, ECO:0000269|PubMed:11012666, ECO:0000269|PubMed:12534281, ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:15039077, ECO:0000269|PubMed:15664838, ECO:0000269|PubMed:20536396, ECO:0000269|PubMed:27820798, ECO:0000269|PubMed:29967349, ECO:0000269|PubMed:32796818, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:34019797, ECO:0000305|PubMed:29382749}.		apoptotic process [GO:0006915]; immune response [GO:0006955]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; serine-type peptidase activity [GO:0008236]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; serine-type peptidase activity [GO:0008236]; apoptotic process [GO:0006915]; immune response [GO:0006955]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11012666, ECO:0000269|PubMed:12534281, ECO:0000269|PubMed:12662155}.
Q6VAB6	reviewed	KSR2_HUMAN	Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1)	KSR2	Homo sapiens (Human)	950	FUNCTION: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. {ECO:0000269|PubMed:12975377, ECO:0000269|PubMed:16039990, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126}.		calcium-mediated signaling [GO:0019722]; phosphorylation [GO:0016310]; positive regulation of cold-induced thermogenesis [GO:0120162]; Ras protein signal transduction [GO:0007265]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; calcium-mediated signaling [GO:0019722]; phosphorylation [GO:0016310]; positive regulation of cold-induced thermogenesis [GO:0120162]; Ras protein signal transduction [GO:0007265]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q6VB84	reviewed	FX4L3_HUMAN	Forkhead box protein D4-like 3 (FOXD4-like 3)	FOXD4L3	Homo sapiens (Human)	417			anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Q6VEQ5	reviewed	WASH2_HUMAN	WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B)	WASH2P FAM39B	Homo sapiens (Human)	465	FUNCTION: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}.	MISCELLANEOUS: WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units. Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene. {ECO:0000305|PubMed:18159949}.	Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]	autophagosome [GO:0005776]; centriole [GO:0005814]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]	autophagosome [GO:0005776]; centriole [GO:0005814]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:A8K0Z3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8VDD8}. Late endosome {ECO:0000250|UniProtKB:A8K0Z3}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q8VDD8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8VDD8}. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2. {ECO:0000250|UniProtKB:A8K0Z3}.
Q6VMQ6	reviewed	MCAF1_HUMAN	Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621)	ATF7IP MCAF MCAF1	Homo sapiens (Human)	1270	FUNCTION: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}.		DNA methylation [GO:0006306]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; positive regulation of DNA-templated transcription [GO:0045893]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein stability [GO:0031647]; regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045898]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	ATP hydrolysis activity [GO:0016887]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ATP hydrolysis activity [GO:0016887]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; DNA methylation [GO:0006306]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; positive regulation of DNA-templated transcription [GO:0045893]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein stability [GO:0031647]; regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045898]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}.
Q6VN20	reviewed	RBP10_HUMAN	Ran-binding protein 10 (RanBP10)	RANBP10 KIAA1464	Homo sapiens (Human)	620	FUNCTION: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250|UniProtKB:Q6VN19, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:29911972, ECO:0000305}.		cytoskeleton organization [GO:0007010]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; cytoskeleton organization [GO:0007010]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18222118}. Nucleus {ECO:0000269|PubMed:18222118}. Note=Predominantly cytoplasmic.
Q6VVB1	reviewed	NHLC1_HUMAN	E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1)	NHLRC1 EPM2B	Homo sapiens (Human)	395	FUNCTION: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. {ECO:0000269|PubMed:15930137, ECO:0000269|PubMed:17908927, ECO:0000269|PubMed:18070875, ECO:0000269|PubMed:19036738, ECO:0000269|PubMed:21505799, ECO:0000269|PubMed:23624058}.		autophagy [GO:0006914]; glycogen biosynthetic process [GO:0005978]; negative regulation of translation [GO:0017148]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein phosphorylation [GO:0001932]; response to endoplasmic reticulum stress [GO:0034976]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	metal ion binding [GO:0046872]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; metal ion binding [GO:0046872]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; autophagy [GO:0006914]; glycogen biosynthetic process [GO:0005978]; negative regulation of translation [GO:0017148]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein phosphorylation [GO:0001932]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum. Nucleus. Note=Localizes at the endoplasmic reticulum and, to a lesser extent, in the nucleus.
Q6VVX0	reviewed	CP2R1_HUMAN	Vitamin D 25-hydroxylase (EC 1.14.14.24) (Cytochrome P450 2R1)	CYP2R1	Homo sapiens (Human)	501	FUNCTION: A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol) (PubMed:12867411, PubMed:15465040, PubMed:18511070). Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives (PubMed:15465040, PubMed:18511070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:12867411, PubMed:15465040, PubMed:18511070). {ECO:0000269|PubMed:12867411, ECO:0000269|PubMed:15465040, ECO:0000269|PubMed:18511070}.		calcitriol biosynthetic process from calciol [GO:0036378]; organic acid metabolic process [GO:0006082]; response to cesium ion [GO:0010164]; response to ionizing radiation [GO:0010212]; vitamin D metabolic process [GO:0042359]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	D3 vitamins binding [GO:1902271]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; protein homodimerization activity [GO:0042803]; steroid hydroxylase activity [GO:0008395]; vitamin D3 25-hydroxylase activity [GO:0030343]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; D3 vitamins binding [GO:1902271]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; protein homodimerization activity [GO:0042803]; steroid hydroxylase activity [GO:0008395]; vitamin D3 25-hydroxylase activity [GO:0030343]; calcitriol biosynthetic process from calciol [GO:0036378]; organic acid metabolic process [GO:0006082]; response to cesium ion [GO:0010164]; response to ionizing radiation [GO:0010212]; vitamin D metabolic process [GO:0042359]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:15465040}; Peripheral membrane protein. Microsome membrane {ECO:0000305|PubMed:15465040}; Peripheral membrane protein.
Q6VY07	reviewed	PACS1_HUMAN	Phosphofurin acidic cluster sorting protein 1 (PACS-1)	PACS1 KIAA1175	Homo sapiens (Human)	963	FUNCTION: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}.		lymphocyte homeostasis [GO:0002260]; protein localization to Golgi apparatus [GO:0034067]; protein localization to plasma membrane [GO:0072659]	COPI-coated vesicle [GO:0030137]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]	transmembrane transporter binding [GO:0044325]	COPI-coated vesicle [GO:0030137]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; transmembrane transporter binding [GO:0044325]; lymphocyte homeostasis [GO:0002260]; protein localization to Golgi apparatus [GO:0034067]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O88588}. Note=Localizes in the perinuclear region, probably the TGN. {ECO:0000305|PubMed:11331585}.
Q6W0C5	reviewed	DPPA3_HUMAN	Developmental pluripotency-associated protein 3 (Stella-related protein)	DPPA3 STELLAR	Homo sapiens (Human)	159	FUNCTION: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization (PubMed:35314832). In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process (By similarity). Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation (By similarity). Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark (By similarity). Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis (By similarity). May be important for the totipotent/pluripotent states continuing through preimplantation development (By similarity). Also involved in chromatin condensation in oocytogenesis (By similarity). {ECO:0000250|UniProtKB:Q8QZY3, ECO:0000269|PubMed:35314832}.		epigenetic programing of female pronucleus [GO:0044726]; negative regulation of DNA demethylation [GO:1901536]	cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; nucleus [GO:0005634]	methylated histone binding [GO:0035064]	cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; nucleus [GO:0005634]; methylated histone binding [GO:0035064]; epigenetic programing of female pronucleus [GO:0044726]; negative regulation of DNA demethylation [GO:1901536]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21421998}. Cytoplasm {ECO:0000269|PubMed:21421998}. Note=Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker. {ECO:0000250|UniProtKB:Q8QZY3}.
Q6W2J9	reviewed	BCOR_HUMAN	BCL-6 corepressor (BCoR)	BCOR KIAA1575	Homo sapiens (Human)	1755	FUNCTION: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}.		blastocyst hatching [GO:0001835]; chromatin remodeling [GO:0006338]; heart development [GO:0007507]; negative regulation of bone mineralization [GO:0030502]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of tooth mineralization [GO:0070171]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; roof of mouth development [GO:0060021]; specification of axis polarity [GO:0065001]	BCOR complex [GO:0140261]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]	BCOR complex [GO:0140261]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]; blastocyst hatching [GO:0001835]; chromatin remodeling [GO:0006338]; heart development [GO:0007507]; negative regulation of bone mineralization [GO:0030502]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of tooth mineralization [GO:0070171]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; roof of mouth development [GO:0060021]; specification of axis polarity [GO:0065001]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10898795}.
Q6W4X9	reviewed	MUC6_HUMAN	Mucin-6 (MUC-6) (Gastric mucin-6)	MUC6	Homo sapiens (Human)	2439	FUNCTION: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. {ECO:0000269|PubMed:10209489, ECO:0000269|PubMed:10330458, ECO:0000269|PubMed:11988092}.		maintenance of gastrointestinal epithelium [GO:0030277]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	extracellular matrix structural constituent [GO:0005201]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; extracellular matrix structural constituent [GO:0005201]; maintenance of gastrointestinal epithelium [GO:0030277]	SUBCELLULAR LOCATION: Secreted.
Q6W5P4	reviewed	NPSR1_HUMAN	Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility)	NPSR1 GPR154 GPRA PGR14	Homo sapiens (Human)	371	FUNCTION: G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases. {ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16790440}.	MISCELLANEOUS: Only isoforms with 7 transmembrane topology (isoform 1, isoform 3 and isoform 4) are transported into the plasma membrane in transfected cells, while the truncated ones retain intracellular compartments. {ECO:0000269|PubMed:15947423}.	eating behavior [GO:0042755]; negative regulation of defecation [GO:2000293]; negative regulation of eating behavior [GO:1903999]; neuropeptide signaling pathway [GO:0007218]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; righting reflex [GO:0060013]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	neuropeptide receptor activity [GO:0008188]; vasopressin receptor activity [GO:0005000]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; neuropeptide receptor activity [GO:0008188]; vasopressin receptor activity [GO:0005000]; eating behavior [GO:0042755]; negative regulation of defecation [GO:2000293]; negative regulation of eating behavior [GO:1903999]; neuropeptide signaling pathway [GO:0007218]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; righting reflex [GO:0060013]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16790440}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:15947423}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:15947423}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15947423}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:15947423}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000269|PubMed:15947423}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm {ECO:0000269|PubMed:15947423}.; SUBCELLULAR LOCATION: [Isoform 9]: Cytoplasm {ECO:0000269|PubMed:15947423}.
Q6WCQ1	reviewed	MPRIP_HUMAN	Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)	MPRIP KIAA0864 MRIP RHOIP3	Homo sapiens (Human)	1025	FUNCTION: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.			actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14506264, ECO:0000269|PubMed:16257966}. Note=Colocalizes with F-actin.
Q6WKZ4	reviewed	RFIP1_HUMAN	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein)	RAB11FIP1 RCP	Homo sapiens (Human)	1283	FUNCTION: A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206}.		negative regulation of adiponectin secretion [GO:0070164]; protein transport [GO:0015031]; regulated exocytosis [GO:0045055]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic vesicle membrane [GO:0030670]; recycling endosome [GO:0055037]	small GTPase binding [GO:0031267]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic vesicle membrane [GO:0030670]; recycling endosome [GO:0055037]; small GTPase binding [GO:0031267]; negative regulation of adiponectin secretion [GO:0070164]; protein transport [GO:0015031]; regulated exocytosis [GO:0045055]	SUBCELLULAR LOCATION: Recycling endosome {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15280022, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206}. Note=Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC).; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasmic vesicle, phagosome membrane. Note=Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).
Q6WN34	reviewed	CRDL2_HUMAN	Chordin-like protein 2 (Breast tumor novel factor 1) (BNF-1) (Chordin-related protein 2)	CHRDL2 BNF1 CHL2 UNQ765/PRO1557	Homo sapiens (Human)	429	FUNCTION: May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. {ECO:0000250, ECO:0000269|PubMed:12853144, ECO:0000269|PubMed:15094188}.		cartilage development [GO:0051216]; cell differentiation [GO:0030154]; negative regulation of BMP signaling pathway [GO:0030514]; ossification [GO:0001503]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	BMP binding [GO:0036122]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; BMP binding [GO:0036122]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; negative regulation of BMP signaling pathway [GO:0030514]; ossification [GO:0001503]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.
Q6WRI0	reviewed	IGS10_HUMAN	Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608)	IGSF10 CMF608	Homo sapiens (Human)	2623	FUNCTION: Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity). {ECO:0000250|UniProtKB:Q3V1M1, ECO:0000250|UniProtKB:Q6WRH9}.		cell differentiation [GO:0030154]; ossification [GO:0001503]; regulation of neuron migration [GO:2001222]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; cell differentiation [GO:0030154]; ossification [GO:0001503]; regulation of neuron migration [GO:2001222]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27137492}.
Q6X4U4	reviewed	SOSD1_HUMAN	Sclerostin domain-containing protein 1 (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1)	SOSTDC1 USAG1 CDA019	Homo sapiens (Human)	206	FUNCTION: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. {ECO:0000250, ECO:0000269|PubMed:15020244}.		canonical Wnt signaling pathway [GO:0060070]; epithelial cell fate commitment [GO:0072148]; hair follicle morphogenesis [GO:0031069]; mammary gland bud morphogenesis [GO:0060648]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell fate commitment [GO:0010454]; negative regulation of determination of dorsal identity [GO:2000016]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of Wnt signaling pathway [GO:0030178]; odontogenesis of dentin-containing tooth [GO:0042475]; pattern specification process [GO:0007389]	extracellular space [GO:0005615]	BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]	extracellular space [GO:0005615]; BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]; canonical Wnt signaling pathway [GO:0060070]; epithelial cell fate commitment [GO:0072148]; hair follicle morphogenesis [GO:0031069]; mammary gland bud morphogenesis [GO:0060648]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell fate commitment [GO:0010454]; negative regulation of determination of dorsal identity [GO:2000016]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of Wnt signaling pathway [GO:0030178]; odontogenesis of dentin-containing tooth [GO:0042475]; pattern specification process [GO:0007389]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15020244}.
Q6X4W1	reviewed	NSMF_HUMAN	NMDA receptor synaptonuclear signaling and neuronal migration factor (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor)	NSMF NELF	Homo sapiens (Human)	530	FUNCTION: Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. {ECO:0000269|PubMed:20025934}.	MISCELLANEOUS: NSMF mRNAs expressed in the hippocampus exhibit a prominent dendritic localization which is mediated by a dendritic targeting element (DTE) residing in the 3'-untranslated region (3'UTR). Transport from dendrites to the nucleus is induced by NMDA receptor activation and results in a rapid stripping of synaptic contacts and a reduction of dendritic complexity (By similarity). {ECO:0000250}.	cellular response to amino acid stimulus [GO:0071230]; cellular response to electrical stimulus [GO:0071257]; cellular response to gonadotropin stimulus [GO:0071371]; positive regulation of neuron migration [GO:2001224]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of dendrite morphogenesis [GO:0048814]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuronal synaptic plasticity [GO:0048168]	apical dendrite [GO:0097440]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; euchromatin [GO:0000791]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	calcium-dependent protein binding [GO:0048306]	apical dendrite [GO:0097440]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; euchromatin [GO:0000791]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202]; calcium-dependent protein binding [GO:0048306]; cellular response to amino acid stimulus [GO:0071230]; cellular response to electrical stimulus [GO:0071257]; cellular response to gonadotropin stimulus [GO:0071371]; positive regulation of neuron migration [GO:2001224]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of dendrite morphogenesis [GO:0048814]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuronal synaptic plasticity [GO:0048168]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20025934}. Nucleus envelope {ECO:0000250}. Nucleus membrane {ECO:0000250}. Nucleus matrix {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:20025934}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:20025934}; Peripheral membrane protein {ECO:0000269|PubMed:20025934}. Cell projection, dendrite {ECO:0000250}. Synapse {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Postsynaptic density {ECO:0000250}. Membrane {ECO:0000250}. Note=Found on the outside of the luteinizing-hormone-releasing hormone (LHRH) cell membrane and axons projecting from the olfactory pit and epithelium. Associates with transcriptionally active chromatin regions. Detected at the nuclear membranes of CA1 neurons. Cortical cytoskeleton. Localized in proximal apical dendrites. Colocalizes with CABP1 in dendrites and dendritic spines. Myristoylation is a prerequisite for extranuclear localization. Translocates from dendrites to the nucleus during NMDA receptor-dependent long-term potentiation (LTP) induction of synaptic transmission at Schaffer collateral/CA1 synapses of hippocampal primary neurons and in a importin-dependent manner (By similarity). {ECO:0000250}.
Q6XD76	reviewed	ASCL4_HUMAN	Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44)	ASCL4 BHLHA44 HASH4	Homo sapiens (Human)	172	FUNCTION: Could be a transcriptional regulator involved in skin development. {ECO:0000269|PubMed:15475265}.		regulation of transcription by RNA polymerase II [GO:0006357]; skin development [GO:0043588]	chromatin [GO:0000785]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]; skin development [GO:0043588]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q6XE24	reviewed	RBMS3_HUMAN	RNA-binding motif, single-stranded-interacting protein 3	RBMS3	Homo sapiens (Human)	437	FUNCTION: Binds poly(A) and poly(U) oligoribonucleotides. {ECO:0000269|PubMed:10675610}.		defense response to tumor cell [GO:0002357]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; defense response to tumor cell [GO:0002357]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10675610}.
Q6XPS3	reviewed	TPTE2_HUMAN	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)	TPTE2 TPIP	Homo sapiens (Human)	522	FUNCTION: Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000269|PubMed:11716755}.; FUNCTION: [Isoform 4]: Shows no phosphoinositide phosphatase activity. {ECO:0000269|PubMed:11716755}.	MISCELLANEOUS: [Isoform 6]: Expressed in testis, strongly inhibits cell growth in HeLa cells. {ECO:0000305}.	dephosphorylation [GO:0016311]; phosphatidylinositol biosynthetic process [GO:0006661]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [GO:0051800]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [GO:0051800]; dephosphorylation [GO:0016311]; phosphatidylinositol biosynthetic process [GO:0006661]	SUBCELLULAR LOCATION: [Isoform 3]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11716755}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14659893}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:14659893}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:11716755}.
Q6XQN6	reviewed	PNCB_HUMAN	Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) (FHA-HIT-interacting protein) (Nicotinate phosphoribosyltransferase domain-containing protein 1)	NAPRT FHIP NAPRT1	Homo sapiens (Human)	538	FUNCTION: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275). {ECO:0000269|PubMed:17604275, ECO:0000269|PubMed:21742010, ECO:0000269|PubMed:26042198}.		NAD salvage [GO:0034355]; response to oxidative stress [GO:0006979]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	metal ion binding [GO:0046872]; nicotinate phosphoribosyltransferase activity [GO:0004516]; transferase activity [GO:0016740]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; metal ion binding [GO:0046872]; nicotinate phosphoribosyltransferase activity [GO:0004516]; transferase activity [GO:0016740]; NAD salvage [GO:0034355]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17604275}.
Q6XR72	reviewed	ZNT10_HUMAN	Calcium/manganese antiporter SLC30A10 (Solute carrier family 30 member 10) (Zinc transporter 10) (ZnT-10)	SLC30A10 ZNT10 ZNT8	Homo sapiens (Human)	485	FUNCTION: Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange (PubMed:30755481). Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis (PubMed:22341972, PubMed:25319704, PubMed:27226609, PubMed:27307044, PubMed:26728129). Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (PubMed:22427991, PubMed:26728129). {ECO:0000269|PubMed:22341972, ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:25319704, ECO:0000269|PubMed:26728129, ECO:0000269|PubMed:27226609, ECO:0000269|PubMed:27307044, ECO:0000269|PubMed:30755481}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to angiotensin [GO:1904385]; detoxification of zinc ion [GO:0010312]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular manganese ion homeostasis [GO:0030026]; intracellular zinc ion homeostasis [GO:0006882]; manganese ion export across plasma membrane [GO:0140048]; manganese ion transport [GO:0006828]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]	calcium:manganese antiporter activity [GO:0140983]; manganese ion transmembrane transporter activity [GO:0005384]; zinc ion transmembrane transporter activity [GO:0005385]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; calcium:manganese antiporter activity [GO:0140983]; manganese ion transmembrane transporter activity [GO:0005384]; zinc ion transmembrane transporter activity [GO:0005385]; cellular response to angiotensin [GO:1904385]; detoxification of zinc ion [GO:0010312]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular manganese ion homeostasis [GO:0030026]; intracellular zinc ion homeostasis [GO:0006882]; manganese ion export across plasma membrane [GO:0140048]; manganese ion transport [GO:0006828]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22706290, ECO:0000269|PubMed:25319704, ECO:0000269|PubMed:26728129, ECO:0000269|PubMed:27226609, ECO:0000269|PubMed:27307044}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:22706290, ECO:0000269|PubMed:27226609}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:26728129}. Early endosome membrane {ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:26728129}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to the Golgi and plasma membrane is regulated by zinc. {ECO:0000269|PubMed:22706290}.
Q6XUX3	reviewed	DUSTY_HUMAN	Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496)	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	Homo sapiens (Human)	929	FUNCTION: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}.		cellular response to fibroblast growth factor stimulus [GO:0044344]; negative regulation of apoptotic process [GO:0043066]; phosphorylation [GO:0016310]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of kinase activity [GO:0033674]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; cellular response to fibroblast growth factor stimulus [GO:0044344]; negative regulation of apoptotic process [GO:0043066]; phosphorylation [GO:0016310]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of kinase activity [GO:0033674]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974}. Cell membrane {ECO:0000250|UniProtKB:Q6XUX1}. Apical cell membrane {ECO:0000269|PubMed:23862974}. Basolateral cell membrane {ECO:0000269|PubMed:23862974}. Cell junction {ECO:0000250|UniProtKB:Q6XUX1}. Note=Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia. {ECO:0000250|UniProtKB:Q6XUX1, ECO:0000269|PubMed:23862974}.
Q6XYQ8	reviewed	SYT10_HUMAN	Synaptotagmin-10 (Synaptotagmin X) (SytX)	SYT10	Homo sapiens (Human)	523	FUNCTION: Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). {ECO:0000250|UniProtKB:O08625, ECO:0000250|UniProtKB:Q9R0N4}.		calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; sensory perception of smell [GO:0007608]	exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; transport vesicle membrane [GO:0030658]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905]	exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; transport vesicle membrane [GO:0030658]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905]; calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q9R0N4}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to neuronal vesicles containing IGF1 that are not enriched at synapses. Does not colocalize with synaptic vesicles or with the Golgi apparatus. {ECO:0000250|UniProtKB:Q9R0N4}.
Q6XZB0	reviewed	LIPI_HUMAN	Lipase member I (LIPI) (EC 3.1.1.-) (Cancer/testis antigen 17) (CT17) (LPD lipase) (Membrane-associated phosphatidic acid-selective phospholipase A1-beta) (mPA-PLA1 beta)	LIPI LPDL PRED5	Homo sapiens (Human)	460	FUNCTION: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). {ECO:0000269|PubMed:12963729}.		lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	carboxylic ester hydrolase activity [GO:0052689]; heparin binding [GO:0008201]; phospholipase activity [GO:0004620]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; carboxylic ester hydrolase activity [GO:0052689]; heparin binding [GO:0008201]; phospholipase activity [GO:0004620]; lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12963729}. Secreted {ECO:0000269|PubMed:12963729}. Note=May associate with lipid draft. {ECO:0000269|PubMed:12963729}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:12963729}. Secreted {ECO:0000269|PubMed:12963729}. Note=May associate with lipid draft. {ECO:0000269|PubMed:12963729}.
Q6XZF7	reviewed	DNMBP_HUMAN	Dynamin-binding protein (Scaffold protein Tuba)	DNMBP ARHGEF36 KIAA1010 TUBA	Homo sapiens (Human)	1577	FUNCTION: Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:19767742, PubMed:17015620). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}.		cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; presynapse [GO:0098793]; synapse [GO:0045202]	guanyl-nucleotide exchange factor activity [GO:0005085]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; presynapse [GO:0098793]; synapse [GO:0045202]; guanyl-nucleotide exchange factor activity [GO:0005085]; cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17015620}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:Q6TXD4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6TXD4}. Synapse {ECO:0000250|UniProtKB:M0R4F8}. Cell junction {ECO:0000269|PubMed:17015620}. Note=Localizes to the apical junction, colocalizes with TJP1. {ECO:0000269|PubMed:17015620}.
Q6Y1H2	reviewed	HACD2_HUMAN	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 2) (HACD2) (Protein-tyrosine phosphatase-like member B)	HACD2 PTPLB	Homo sapiens (Human)	254	FUNCTION: Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.	MISCELLANEOUS: Turns over rapidly through degradation by the proteasome system. {ECO:0000269|PubMed:15024066}.	fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15024066, ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:15024066, ECO:0000269|PubMed:18554506}.
Q6Y288	reviewed	B3GLT_HUMAN	Beta-1,3-glucosyltransferase (Beta3Glc-T) (EC 2.4.1.-) (Beta 3-glucosyltransferase) (Beta-3-glycosyltransferase-like)	B3GLCT B3GALTL B3GTL	Homo sapiens (Human)	498	FUNCTION: O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. {ECO:0000269|PubMed:16899492}.		fucose metabolic process [GO:0006004]; protein O-linked fucosylation [GO:0036066]	endoplasmic reticulum membrane [GO:0005789]	acetylglucosaminyltransferase activity [GO:0008375]; glycosyltransferase activity [GO:0016757]	endoplasmic reticulum membrane [GO:0005789]; acetylglucosaminyltransferase activity [GO:0008375]; glycosyltransferase activity [GO:0016757]; fucose metabolic process [GO:0006004]; protein O-linked fucosylation [GO:0036066]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:16899492}; Single-pass type II membrane protein {ECO:0000269|PubMed:16899492}.
Q6Y7W6	reviewed	GGYF2_HUMAN	GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein)	GIGYF2 KIAA0642 PERQ2 TNRC15	Homo sapiens (Human)	1299	FUNCTION: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}.		adult locomotory behavior [GO:0008344]; feeding behavior [GO:0007631]; homeostasis of number of cells within a tissue [GO:0048873]; insulin-like growth factor receptor signaling pathway [GO:0048009]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA destabilization [GO:0061157]; multicellular organism growth [GO:0035264]; musculoskeletal movement [GO:0050881]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; neuromuscular process controlling balance [GO:0050885]; post-embryonic development [GO:0009791]; post-transcriptional gene silencing [GO:0016441]; rescue of stalled ribosome [GO:0072344]; spinal cord motor neuron differentiation [GO:0021522]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]; proximal dendrite [GO:1990635]; vesicle [GO:0031982]	cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064]; RNA binding [GO:0003723]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]; proximal dendrite [GO:1990635]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064]; RNA binding [GO:0003723]; adult locomotory behavior [GO:0008344]; feeding behavior [GO:0007631]; homeostasis of number of cells within a tissue [GO:0048873]; insulin-like growth factor receptor signaling pathway [GO:0048009]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA destabilization [GO:0061157]; multicellular organism growth [GO:0035264]; musculoskeletal movement [GO:0050881]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; neuromuscular process controlling balance [GO:0050885]; post-embryonic development [GO:0009791]; post-transcriptional gene silencing [GO:0016441]; rescue of stalled ribosome [GO:0072344]; spinal cord motor neuron differentiation [GO:0021522]	
Q6YBV0	reviewed	S36A4_HUMAN	Neutral amino acid uniporter 4 (Solute carrier family 36 member 4)	SLC36A4 PAT4	Homo sapiens (Human)	504	FUNCTION: Uniporter that mediates the transport of neutral amino acids like L-tryptophan, proline and alanine (PubMed:21097500). The transport activity is sodium ions-independent, electroneutral and therefore functions via facilitated diffusion (PubMed:21097500). {ECO:0000269|PubMed:21097500}.		amino acid transmembrane transport [GO:0003333]; L-alanine transport [GO:0015808]; L-proline import across plasma membrane [GO:1904271]; L-tryptophan transmembrane transport [GO:1904556]; proline transport [GO:0015824]; tryptophan transport [GO:0015827]	lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]	L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; L-tryptophan transmembrane transporter activity [GO:0015196]; symporter activity [GO:0015293]	lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; L-tryptophan transmembrane transporter activity [GO:0015196]; symporter activity [GO:0015293]; amino acid transmembrane transport [GO:0003333]; L-alanine transport [GO:0015808]; L-proline import across plasma membrane [GO:1904271]; L-tryptophan transmembrane transport [GO:1904556]; proline transport [GO:0015824]; tryptophan transport [GO:0015827]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8CH36}; Multi-pass membrane protein {ECO:0000255}.
Q6YHK3	reviewed	CD109_HUMAN	CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)	CD109 CPAMD7	Homo sapiens (Human)	1445	FUNCTION: Modulates negatively TGFB1 signaling in keratinocytes. {ECO:0000269|PubMed:16754747}.		hair follicle development [GO:0001942]; keratinocyte proliferation [GO:0043616]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616]; stem cell proliferation [GO:0072089]	cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; side of membrane [GO:0098552]	serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431]	cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; side of membrane [GO:0098552]; serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431]; hair follicle development [GO:0001942]; keratinocyte proliferation [GO:0043616]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11861284, ECO:0000269|PubMed:16754747}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11861284, ECO:0000269|PubMed:16754747}.
Q6YHU6	reviewed	THADA_HUMAN	tRNA (32-2'-O)-methyltransferase regulator THADA (Gene inducing thyroid adenomas protein) (Thyroid adenoma-associated protein)	THADA GITA KIAA1767	Homo sapiens (Human)	1953	FUNCTION: Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs. {ECO:0000269|PubMed:25404562}.		adaptive thermogenesis [GO:1990845]; lipid homeostasis [GO:0055088]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; tRNA methylation [GO:0030488]; tRNA nucleoside ribose methylation [GO:0002128]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]	enzyme regulator activity [GO:0030234]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; enzyme regulator activity [GO:0030234]; adaptive thermogenesis [GO:1990845]; lipid homeostasis [GO:0055088]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; tRNA methylation [GO:0030488]; tRNA nucleoside ribose methylation [GO:0002128]	
Q6YN16	reviewed	HSDL2_HUMAN	Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) (Short chain dehydrogenase/reductase family 13C member 1)	HSDL2 C9orf99 SDR13C1	Homo sapiens (Human)	418	FUNCTION: Has apparently no steroid dehydrogenase activity. {ECO:0000269|PubMed:19703561}.			membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]	oxidoreductase activity [GO:0016491]	membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]; oxidoreductase activity [GO:0016491]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:19703561}.
Q6YP21	reviewed	KAT3_HUMAN	Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III)	KYAT3 CCBL2 KAT3	Homo sapiens (Human)	454	FUNCTION: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro). {ECO:0000250|UniProtKB:Q71RI9}.		2-oxoglutarate metabolic process [GO:0006103]; amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058]; kynurenine metabolic process [GO:0070189]; L-kynurenine catabolic process [GO:0097053]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	cysteine-S-conjugate beta-lyase activity [GO:0047804]; kynurenine-glyoxylate transaminase activity [GO:0047315]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; cysteine-S-conjugate beta-lyase activity [GO:0047804]; kynurenine-glyoxylate transaminase activity [GO:0047315]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; RNA binding [GO:0003723]; 2-oxoglutarate metabolic process [GO:0006103]; amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058]; kynurenine metabolic process [GO:0070189]; L-kynurenine catabolic process [GO:0097053]	
Q6ZMB0	reviewed	B3GN6_HUMAN	Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.147) (Core 3 synthase) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6) (BGnT-6) (Beta-1,3-Gn-T6) (Beta-1,3-N-acetylglucosaminyltransferase 6) (Beta3Gn-T6)	B3GNT6	Homo sapiens (Human)	384	FUNCTION: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs.	MISCELLANEOUS: Injection into nude mice significantly suppress lung metastasis, indicating that the core structures of O-glycans are profoundly involved in the metastatic capacity of cancer cells.	glycoprotein biosynthetic process [GO:0009101]; O-glycan processing [GO:0016266]; O-glycan processing, core 3 [GO:0016269]; protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0106328]; acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0106327]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; galactosyltransferase activity [GO:0008378]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; UDP-glycosyltransferase activity [GO:0008194]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0106328]; acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0106327]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; galactosyltransferase activity [GO:0008378]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; UDP-glycosyltransferase activity [GO:0008194]; glycoprotein biosynthetic process [GO:0009101]; O-glycan processing [GO:0016266]; O-glycan processing, core 3 [GO:0016269]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15755813}; Single-pass type II membrane protein {ECO:0000269|PubMed:15755813}.
Q6ZMC9	reviewed	SIG15_HUMAN	Sialic acid-binding Ig-like lectin 15 (Siglec-15) (CD33 antigen-like 3)	SIGLEC15 CD33L3	Homo sapiens (Human)	328	FUNCTION: Binds sialylated glycoproteins. {ECO:0000269|PubMed:17483134}.		regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of osteoclast development [GO:2001204]	plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]		plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of osteoclast development [GO:2001204]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q6ZMG9	reviewed	CERS6_HUMAN	Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) (Sphingoid base N-palmitoyltransferase CERS6) (EC 2.3.1.291)	CERS6 LASS6	Homo sapiens (Human)	384	FUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624). Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity). {ECO:0000250|UniProtKB:Q8C172, ECO:0000269|PubMed:17609214, ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:31916624}.		ceramide biosynthetic process [GO:0046513]; inflammatory response [GO:0006954]; sphingolipid biosynthetic process [GO:0030148]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291]; ceramide biosynthetic process [GO:0046513]; inflammatory response [GO:0006954]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8C172}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8C172}.
Q6ZMH5	reviewed	S39A5_HUMAN	Zinc transporter ZIP5 (Solute carrier family 39 member 5) (Zrt- and Irt-like protein 5) (ZIP-5)	SLC39A5 ZIP5	Homo sapiens (Human)	540	FUNCTION: Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood into the intestine (By similarity). The transport mechanism is temperature- and concentration-dependent and saturable (By similarity). In addition, is also a high affinity copper transporter in vitro (PubMed:36454509). Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis (By similarity). Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Plays a role in eye development (PubMed:24891338). {ECO:0000250|UniProtKB:Q9D856, ECO:0000269|PubMed:24891338, ECO:0000269|PubMed:36454509}.		angiogenesis [GO:0001525]; BMP signaling pathway [GO:0030509]; cellular response to zinc ion starvation [GO:0034224]; eye development [GO:0001654]; G1 to G0 transition involved in cell differentiation [GO:0070315]; intracellular zinc ion homeostasis [GO:0006882]; neural precursor cell proliferation [GO:0061351]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]	monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]	basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]; angiogenesis [GO:0001525]; BMP signaling pathway [GO:0030509]; cellular response to zinc ion starvation [GO:0034224]; eye development [GO:0001654]; G1 to G0 transition involved in cell differentiation [GO:0070315]; intracellular zinc ion homeostasis [GO:0006882]; neural precursor cell proliferation [GO:0061351]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9D856}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9D856}. Note=Localized to the basolateral surfaces of enterocytes, pancreatic acinar and endoderm cells. During zinc deficiency diet, the basolateral cell membrane localization is lost in the intestine, the visceral yolk sac and acinar cell. During zinc repletion, is relocalized to the basolateral membrane of enterocytes, visceral endoderm cells and pancreatic acinar cells. Zinc can regulate the turnover of protein at the membrane. During zinc deficiency, is internalized and degraded in enterocytes, acinar cells and endoderm cells. Endocytosed through the endolysosomal degradation pathway RAB5A pathway. {ECO:0000250|UniProtKB:Q9D856}.
Q6ZMI0	reviewed	PPR21_HUMAN	Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (KLRAQ motif-containing protein 1)	PPP1R21 CCDC128 KLRAQ1	Homo sapiens (Human)	780	FUNCTION: Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623). May play a role in the endosomal sorting process or in endosome maturation pathway (PubMed:30520571). {ECO:0000269|PubMed:30520571, ECO:0000305|PubMed:19389623}.			early endosome [GO:0005769]; membrane [GO:0016020]		early endosome [GO:0005769]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:30520571}.
Q6ZMI3	reviewed	GLDN_HUMAN	Gliomedin [Cleaved into: Gliomedin shedded ectodomain]	GLDN COLM UNQ9339/PRO34011	Homo sapiens (Human)	551	FUNCTION: Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q8BMF8}.		clustering of voltage-gated sodium channels [GO:0045162]; microvillus organization [GO:0032528]; signal transduction [GO:0007165]	axon [GO:0030424]; cell surface [GO:0009986]; collagen trimer [GO:0005581]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	protein binding involved in heterotypic cell-cell adhesion [GO:0086080]	axon [GO:0030424]; cell surface [GO:0009986]; collagen trimer [GO:0005581]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; clustering of voltage-gated sodium channels [GO:0045162]; microvillus organization [GO:0032528]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80WL1, ECO:0000269|PubMed:27616481}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q80WL1}. Cell projection, axon {ECO:0000250|UniProtKB:Q80WL1}. Note=Detected at the nodes of Ranvier. Detected at immature heminodes. {ECO:0000250|UniProtKB:Q80WL1}.; SUBCELLULAR LOCATION: [Gliomedin shedded ectodomain]: Secreted {ECO:0000250|UniProtKB:Q80WL1}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q80WL1}. Note=Proteolytic processing gives rise to a soluble extracellular domain that is secreted. The gliomedin shedded ectodomain localizes to the nodes of Ranvier. {ECO:0000250|UniProtKB:Q80WL1}.
Q6ZMJ2	reviewed	SCAR5_HUMAN	Scavenger receptor class A member 5 (Scavenger receptor hlg)	SCARA5 UNQ2938/PRO28700	Homo sapiens (Human)	495	FUNCTION: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Preferentially binds ferritin light chain (FTL) compared to heavy chain (FTH1). {ECO:0000255|HAMAP-Rule:MF_03070}.		cellular response to heat [GO:0034605]; endocytosis [GO:0006897]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; protein homotrimerization [GO:0070207]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	ferritin receptor activity [GO:0070287]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; ferritin receptor activity [GO:0070287]; cellular response to heat [GO:0034605]; endocytosis [GO:0006897]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; protein homotrimerization [GO:0070207]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_03070}; Single-pass type II membrane protein {ECO:0000255|HAMAP-Rule:MF_03070}.
Q6ZMJ4	reviewed	IL34_HUMAN	Interleukin-34 (IL-34)	IL34 C16orf77	Homo sapiens (Human)	242	FUNCTION: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. {ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.		inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-34-mediated signaling pathway [GO:0061514]; microglial cell proliferation [GO:0061518]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; macrophage colony-stimulating factor receptor binding [GO:0005157]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; macrophage colony-stimulating factor receptor binding [GO:0005157]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-34-mediated signaling pathway [GO:0061514]; microglial cell proliferation [GO:0061518]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18467591}.
Q6ZMM2	reviewed	ATL5_HUMAN	ADAMTS-like protein 5 (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6)	ADAMTSL5 THSD6	Homo sapiens (Human)	481	FUNCTION: May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM).	MISCELLANEOUS: [Isoform 1]: Major.; MISCELLANEOUS: [Isoform 2]: Minor. {ECO:0000305}.	extracellular matrix organization [GO:0030198]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]	heparin binding [GO:0008201]; microfibril binding [GO:0050436]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]; heparin binding [GO:0008201]; microfibril binding [GO:0050436]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23010571}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:23010571}. Note=Colocalized with fibrillin microfibrils. Predominantly distributed in baso-lateral regions of fibroblast extracellular matrix.
Q6ZMP0	reviewed	THSD4_HUMAN	Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6)	THSD4 UNQ9334/PRO34005	Homo sapiens (Human)	1018	FUNCTION: Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN. {ECO:0000269|PubMed:32855533}.		elastic fiber assembly [GO:0048251]; extracellular matrix organization [GO:0030198]; microfibril assembly [GO:0160054]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; microfibril [GO:0001527]	hydrolase activity [GO:0016787]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; microfibril [GO:0001527]; hydrolase activity [GO:0016787]; elastic fiber assembly [GO:0048251]; extracellular matrix organization [GO:0030198]; microfibril assembly [GO:0160054]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:32855533}.
Q6ZMQ8	reviewed	LMTK1_HUMAN	Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP)	AATK AATYK KIAA0641 LMR1 LMTK1	Homo sapiens (Human)	1374	FUNCTION: May be involved in neuronal differentiation. {ECO:0000269|PubMed:10837911}.		brain development [GO:0007420]; phosphorylation [GO:0016310]	membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; brain development [GO:0007420]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:10837911}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10837911}. Note=Predominantly perinuclear.
Q6ZMR5	reviewed	TM11A_HUMAN	Transmembrane protease serine 11A (EC 3.4.21.-) (Airway trypsin-like protease 1) (Epidermal type-II transmembrane serine protease) (Esophageal cancer-susceptibility gene 1 protein)	TMPRSS11A ECRG1 HATL1 HESP	Homo sapiens (Human)	418	FUNCTION: Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.		cell cycle [GO:0007049]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; cell cycle [GO:0007049]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q6ZMS7	reviewed	ZN783_HUMAN	Zinc finger protein 783	ZNF783	Homo sapiens (Human)	546	FUNCTION: May be involved in transcriptional regulation.	MISCELLANEOUS: [Isoform 2]: Gene prediction based on partial EST data. {ECO:0000305}.; MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZMT1	reviewed	STAC2_HUMAN	SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2)	STAC2	Homo sapiens (Human)	411	FUNCTION: Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:Q8R1B0}.		positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; skeletal muscle contraction [GO:0003009]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; sarcolemma [GO:0042383]	metal ion binding [GO:0046872]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; sarcolemma [GO:0042383]; metal ion binding [GO:0046872]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; skeletal muscle contraction [GO:0003009]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8R1B0}. Cell membrane {ECO:0000250|UniProtKB:Q8R1B0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R1B0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R1B0}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q8R1B0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R1B0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R1B0}. Note=Colocalizes with CACNA1C at the plasma membrane of transfected cells. {ECO:0000250|UniProtKB:Q8R1B0}.
Q6ZMT4	reviewed	KDM7A_HUMAN	Lysine-specific demethylase 7A (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) (EC 1.14.11.65)	KDM7A JHDM1D KDM7 KIAA1718	Homo sapiens (Human)	941	FUNCTION: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (PubMed:20023638, PubMed:20622853). Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3 (PubMed:20023638). Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (PubMed:20622853). {ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20622853}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	midbrain development [GO:0030901]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]; midbrain development [GO:0030901]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q6ZMU5	reviewed	TRI72_HUMAN	Tripartite motif-containing protein 72 (Mitsugumin-53) (Mg53)	TRIM72 MG53	Homo sapiens (Human)	477	FUNCTION: Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). {ECO:0000250}.		exocytosis [GO:0006887]; muscle organ development [GO:0007517]; muscle system process [GO:0003012]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of myotube differentiation [GO:0010832]; plasma membrane repair [GO:0001778]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; sarcolemma [GO:0042383]	identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; phosphatidylserine binding [GO:0001786]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; sarcolemma [GO:0042383]; identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; phosphatidylserine binding [GO:0001786]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; exocytosis [GO:0006887]; muscle organ development [GO:0007517]; muscle system process [GO:0003012]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of myotube differentiation [GO:0010832]; plasma membrane repair [GO:0001778]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine. {ECO:0000250}.
Q6ZMZ0	reviewed	RN19B_HUMAN	E3 ubiquitin-protein ligase RNF19B (EC 2.3.2.31) (IBR domain-containing protein 3) (Natural killer lytic-associated molecule) (RING finger protein 19B)	RNF19B IBRDC3 NKLAM	Homo sapiens (Human)	732	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036). {ECO:0000269|PubMed:10438909, ECO:0000269|PubMed:16709802, ECO:0000269|PubMed:27485036}.		adaptive immune response [GO:0002250]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ubiquitin ligase complex [GO:0000151]	ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ubiquitin ligase complex [GO:0000151]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; adaptive immune response [GO:0002250]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasmic granule membrane {ECO:0000269|PubMed:10438909}; Multi-pass membrane protein {ECO:0000269|PubMed:10438909}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27485036}; Multi-pass membrane protein {ECO:0000305}.
Q6ZMZ3	reviewed	SYNE3_HUMAN	Nesprin-3 (KASH domain-containing protein 3) (KASH3) (Nuclear envelope spectrin repeat protein 3)	SYNE3 C14orf139 C14orf49 LINC00341	Homo sapiens (Human)	975	FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. {ECO:0000269|PubMed:16330710, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:21937718}.		cytoskeleton organization [GO:0007010]; establishment of protein localization to membrane [GO:0090150]; nuclear migration [GO:0007097]; regulation of cell shape [GO:0008360]	cytoplasm [GO:0005737]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; rough endoplasmic reticulum [GO:0005791]	actin filament binding [GO:0051015]; cytoskeleton-nuclear membrane anchor activity [GO:0140444]	cytoplasm [GO:0005737]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; rough endoplasmic reticulum [GO:0005791]; actin filament binding [GO:0051015]; cytoskeleton-nuclear membrane anchor activity [GO:0140444]; cytoskeleton organization [GO:0007010]; establishment of protein localization to membrane [GO:0090150]; nuclear migration [GO:0007097]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000269|PubMed:21937718}; Single-pass type IV membrane protein {ECO:0000269|PubMed:21937718}. Nucleus envelope {ECO:0000269|PubMed:21937718}. Rough endoplasmic reticulum {ECO:0000250}.
Q6ZN04	reviewed	MEX3B_HUMAN	RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195)	MEX3B KIAA2009 RKHD3 RNF195	Homo sapiens (Human)	569	FUNCTION: RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.		protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]	calcium ion binding [GO:0005509]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; calcium ion binding [GO:0005509]; RNA binding [GO:0003723]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18779327}. Cytoplasm {ECO:0000269|PubMed:18779327}. Cytoplasm, P-body {ECO:0000269|PubMed:18779327}. Cytoplasmic granule {ECO:0000269|PubMed:18779327}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.
Q6ZN16	reviewed	M3K15_HUMAN	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15)	MAP3K15 ASK3	Homo sapiens (Human)	1313	FUNCTION: Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway (PubMed:20362554, PubMed:26732173). Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases (PubMed:20362554, PubMed:26732173). May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis (PubMed:20362554). Involved in phosphorylation of WNK4 in response to osmotic stress or hypotonic low-chloride stimulation via the p38 MAPK signal transduction cascade (PubMed:26732173). {ECO:0000269|PubMed:20362554, ECO:0000269|PubMed:26732173}.		phosphorylation [GO:0016310]		ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]	ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; phosphorylation [GO:0016310]	
Q6ZN17	reviewed	LN28B_HUMAN	Protein lin-28 homolog B (Lin-28B)	LIN28B CSDD2	Homo sapiens (Human)	250	FUNCTION: Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. {ECO:0000250|UniProtKB:Q45KJ6, ECO:0000269|PubMed:16971064, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22118463}.		miRNA catabolic process [GO:0010587]; negative regulation of pre-miRNA processing [GO:2000632]; negative regulation of primary miRNA processing [GO:2000635]; positive regulation of miRNA catabolic process [GO:2000627]; pre-miRNA processing [GO:0031054]; RNA 3'-end processing [GO:0031123]; RNA destabilization [GO:0050779]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; miRNA catabolic process [GO:0010587]; negative regulation of pre-miRNA processing [GO:2000632]; negative regulation of primary miRNA processing [GO:2000635]; positive regulation of miRNA catabolic process [GO:2000627]; pre-miRNA processing [GO:0031054]; RNA 3'-end processing [GO:0031123]; RNA destabilization [GO:0050779]	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus {ECO:0000269|PubMed:22118463}. Cytoplasm {ECO:0000269|PubMed:16971064}. Note=Predominantly nucleolar (PubMed:22118463). In Huh7 cells, predominantly cytoplasmic, with only a subset of cells exhibiting strong nuclear staining; however, the specificity of the polyclonal antibody used in these experiments has not been not documented (PubMed:16971064). {ECO:0000269|PubMed:16971064, ECO:0000269|PubMed:22118463}.
Q6ZN18	reviewed	AEBP2_HUMAN	Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2)	AEBP2	Homo sapiens (Human)	517	FUNCTION: Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:31959557, PubMed:29499137). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.		chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29499137}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:29499137}.
Q6ZN30	reviewed	BNC2_HUMAN	Zinc finger protein basonuclin-2	BNC2	Homo sapiens (Human)	1099	FUNCTION: Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (PubMed:14988505). May also play an important role in early urinary-tract development (PubMed:31051115). {ECO:0000269|PubMed:14988505, ECO:0000269|PubMed:31051115}.		endochondral bone growth [GO:0003416]; mesenchyme development [GO:0060485]; regulation of DNA-templated transcription [GO:0006355]; roof of mouth development [GO:0060021]; tongue development [GO:0043586]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; rDNA binding [GO:0000182]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; rDNA binding [GO:0000182]; endochondral bone growth [GO:0003416]; mesenchyme development [GO:0060485]; regulation of DNA-templated transcription [GO:0006355]; roof of mouth development [GO:0060021]; tongue development [GO:0043586]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15081112}.
Q6ZN44	reviewed	UNC5A_HUMAN	Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A)	UNC5A KIAA1976 UNC5H1	Homo sapiens (Human)	842	FUNCTION: Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. {ECO:0000250|UniProtKB:O08721}.	MISCELLANEOUS: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers. {ECO:0000269|PubMed:12655055}.	anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; netrin-activated signaling pathway [GO:0038007]; neuron projection development [GO:0031175]	membrane raft [GO:0045121]; neuron projection membrane [GO:0032589]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	netrin receptor activity [GO:0005042]	membrane raft [GO:0045121]; neuron projection membrane [GO:0032589]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; netrin receptor activity [GO:0005042]; anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; netrin-activated signaling pathway [GO:0038007]; neuron projection development [GO:0031175]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O08721}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O08721}. Membrane raft {ECO:0000250|UniProtKB:O08721}. Cell projection, neuron projection {ECO:0000250|UniProtKB:O08721}. Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones. {ECO:0000250|UniProtKB:O08721}.
Q6ZN55	reviewed	ZN574_HUMAN	Zinc finger protein 574	ZNF574	Homo sapiens (Human)	896	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZN57	reviewed	ZFP2_HUMAN	Zinc finger protein ZFP2 (Zfp-2) (Zinc finger protein 751)	ZFP2 ZNF751	Homo sapiens (Human)	461	FUNCTION: Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZN66	reviewed	GBP6_HUMAN	Guanylate-binding protein 6 (EC 3.6.5.-) (GTP-binding protein 6) (GBP-6) (Guanine nucleotide-binding protein 6)	GBP6	Homo sapiens (Human)	633	FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens, such as bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (By similarity). Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (By similarity). {ECO:0000250|UniProtKB:A0A0G2JDV3}.		cellular response to type II interferon [GO:0071346]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; immune response [GO:0006955]	cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cellular response to type II interferon [GO:0071346]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:A0A0G2JDV3}.
Q6ZNA4	reviewed	RN111_HUMAN	E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia)	RNF111	Homo sapiens (Human)	994	FUNCTION: E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity). {ECO:0000250|UniProtKB:Q99ML9, ECO:0000269|PubMed:14657019, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17591695, ECO:0000269|PubMed:22411132, ECO:0000269|PubMed:23751493, ECO:0000269|PubMed:26656854}.		global genome nucleotide-excision repair [GO:0070911]; pattern specification process [GO:0007389]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]	metal ion binding [GO:0046872]; SMAD binding [GO:0046332]; SUMO polymer binding [GO:0032184]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; metal ion binding [GO:0046872]; SMAD binding [GO:0046332]; SUMO polymer binding [GO:0032184]; ubiquitin protein ligase activity [GO:0061630]; global genome nucleotide-excision repair [GO:0070911]; pattern specification process [GO:0007389]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:23751493}. Cytoplasm {ECO:0000269|PubMed:16601693}. Nucleus, PML body {ECO:0000250|UniProtKB:Q99ML9}. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol. {ECO:0000269|PubMed:16601693}.
Q6ZNB7	reviewed	ALKMO_HUMAN	Alkylglycerol monooxygenase (EC 1.14.16.5) (Transmembrane protein 195)	AGMO TMEM195	Homo sapiens (Human)	445	FUNCTION: Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes. {ECO:0000269|PubMed:20643956}.		ether lipid metabolic process [GO:0046485]; membrane lipid metabolic process [GO:0006643]; triglyceride biosynthetic process [GO:0019432]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	glyceryl-ether monooxygenase activity [GO:0050479]; iron ion binding [GO:0005506]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glyceryl-ether monooxygenase activity [GO:0050479]; iron ion binding [GO:0005506]; ether lipid metabolic process [GO:0046485]; membrane lipid metabolic process [GO:0006643]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20643956}; Multi-pass membrane protein {ECO:0000269|PubMed:20643956}.
Q6ZNC8	reviewed	MBOA1_HUMAN	Lysophospholipid acyltransferase 1 (LPLAT 1) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase MBOAT1) (EC 2.3.1.n6) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 1) (O-acyltransferase domain-containing protein 1)	MBOAT1 OACT1	Homo sapiens (Human)	495	FUNCTION: Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor (PubMed:18772128). May play a role in neurite outgrowth during neuronal differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BH98, ECO:0000269|PubMed:18772128}.		lipid modification [GO:0030258]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid biosynthetic process [GO:0008654]; regulation of neuron projection development [GO:0010975]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; acyltransferase activity [GO:0016746]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; acyltransferase activity [GO:0016746]; lipid modification [GO:0030258]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid biosynthetic process [GO:0008654]; regulation of neuron projection development [GO:0010975]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZNE5	reviewed	BAKOR_HUMAN	Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L)	ATG14 ATG14L KIAA0831	Homo sapiens (Human)	492	FUNCTION: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q8CDJ3, ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20713597, ECO:0000269|PubMed:23878393, ECO:0000269|PubMed:25686604}.		autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; cellular response to glucose starvation [GO:0042149]; cellular response to starvation [GO:0009267]; early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; negative regulation of protein phosphorylation [GO:0001933]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of protein phosphorylation [GO:0001934]; post-transcriptional regulation of gene expression [GO:0010608]; protein targeting to lysosome [GO:0006622]; regulation of macroautophagy [GO:0016241]; regulation of protein complex stability [GO:0061635]; regulation of protein phosphorylation [GO:0001932]; regulation of triglyceride metabolic process [GO:0090207]; response to mitochondrial depolarisation [GO:0098780]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of omegasome membrane [GO:0097629]; extrinsic component of phagophore assembly site membrane [GO:0097632]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; phagocytic vesicle [GO:0045335]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]	GTPase binding [GO:0051020]; protein-membrane adaptor activity [GO:0043495]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of omegasome membrane [GO:0097629]; extrinsic component of phagophore assembly site membrane [GO:0097632]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; phagocytic vesicle [GO:0045335]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; GTPase binding [GO:0051020]; protein-membrane adaptor activity [GO:0043495]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; cellular response to glucose starvation [GO:0042149]; cellular response to starvation [GO:0009267]; early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; negative regulation of protein phosphorylation [GO:0001933]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of protein phosphorylation [GO:0001934]; post-transcriptional regulation of gene expression [GO:0010608]; protein targeting to lysosome [GO:0006622]; regulation of macroautophagy [GO:0016241]; regulation of protein complex stability [GO:0061635]; regulation of protein phosphorylation [GO:0001932]; regulation of triglyceride metabolic process [GO:0090207]; response to mitochondrial depolarisation [GO:0098780]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19050071}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20713597}; Peripheral membrane protein {ECO:0000305}. Preautophagosomal structure membrane {ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:22314358}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:25686604}; Peripheral membrane protein {ECO:0000305}. Note=Cytosolic under nutrient-rich conditions (PubMed:19050071). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (PubMed:19050071). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q8CDJ3}.
Q6ZNE9	reviewed	RUFY4_HUMAN	RUN and FYVE domain-containing protein 4	RUFY4	Homo sapiens (Human)	571	FUNCTION: Positively regulates macroautophagy in primary dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger. {ECO:0000269|PubMed:26416964}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	autophagosome assembly [GO:0000045]; cellular response to interleukin-4 [GO:0071353]; positive regulation of macroautophagy [GO:0016239]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]	metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]; autophagosome assembly [GO:0000045]; cellular response to interleukin-4 [GO:0071353]; positive regulation of macroautophagy [GO:0016239]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:26416964}.
Q6ZNG0	reviewed	ZN620_HUMAN	Zinc finger protein 620	ZNF620	Homo sapiens (Human)	422	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZNH5	reviewed	ZN497_HUMAN	Zinc finger protein 497	ZNF497	Homo sapiens (Human)	498	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZNJ1	reviewed	NBEL2_HUMAN	Neurobeachin-like protein 2	NBEAL2 KIAA0540 UNQ253/PRO290	Homo sapiens (Human)	2754	FUNCTION: Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}.		platelet formation [GO:0030220]; protein localization [GO:0008104]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	protein kinase binding [GO:0019901]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; protein kinase binding [GO:0019901]; platelet formation [GO:0030220]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:21765412}.
Q6ZNK6	reviewed	TIFAB_HUMAN	TRAF-interacting protein with FHA domain-containing protein B (TIFA-like protein)	TIFAB	Homo sapiens (Human)	161	FUNCTION: Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA. {ECO:0000269|PubMed:15047173}.		auditory behavior [GO:0031223]; canonical NF-kappaB signal transduction [GO:0007249]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; craniofacial suture morphogenesis [GO:0097094]; genitalia development [GO:0048806]; genitalia morphogenesis [GO:0035112]; hard palate morphogenesis [GO:1905748]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; learned vocalization behavior [GO:0098583]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; mastication [GO:0071626]; myeloid cell differentiation [GO:0030099]; negative regulation of relaxation of muscle [GO:1901078]; negative regulation of saliva secretion [GO:1905747]; neuromuscular process controlling balance [GO:0050885]; peristalsis [GO:0030432]; regulation of gene expression [GO:0010468]; regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1902238]; regulation of muscle organ development [GO:0048634]; thorax and anterior abdomen determination [GO:0007356]; TRAF-mediated signal transduction [GO:0038008]; trigeminal nerve development [GO:0021559]; vestibulocochlear nerve formation [GO:0021650]		deubiquitinase activator activity [GO:0035800]	deubiquitinase activator activity [GO:0035800]; auditory behavior [GO:0031223]; canonical NF-kappaB signal transduction [GO:0007249]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; craniofacial suture morphogenesis [GO:0097094]; genitalia development [GO:0048806]; genitalia morphogenesis [GO:0035112]; hard palate morphogenesis [GO:1905748]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; learned vocalization behavior [GO:0098583]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; mastication [GO:0071626]; myeloid cell differentiation [GO:0030099]; negative regulation of relaxation of muscle [GO:1901078]; negative regulation of saliva secretion [GO:1905747]; neuromuscular process controlling balance [GO:0050885]; peristalsis [GO:0030432]; regulation of gene expression [GO:0010468]; regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1902238]; regulation of muscle organ development [GO:0048634]; thorax and anterior abdomen determination [GO:0007356]; TRAF-mediated signal transduction [GO:0038008]; trigeminal nerve development [GO:0021559]; vestibulocochlear nerve formation [GO:0021650]	
Q6ZNL6	reviewed	FGD5_HUMAN	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)	FGD5 ZFYVE23	Homo sapiens (Human)	1462	FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}.		actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22328776}. Cell projection, ruffle membrane {ECO:0000269|PubMed:22328776}. Endoplasmic reticulum {ECO:0000269|PubMed:22328776}. Golgi apparatus {ECO:0000269|PubMed:22328776}. Early endosome {ECO:0000269|PubMed:22328776}. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
Q6ZNX1	reviewed	SHLD3_HUMAN	Shieldin complex subunit 3 (REV7-interacting novel NHEJ regulator 1) (Shield complex subunit 3)	SHLD3 FLJ26957 RINN1	Homo sapiens (Human)	250	FUNCTION: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. {ECO:0000269|PubMed:29656893}.	MISCELLANEOUS: In BRCA1-deficient cells, function of the shieldin complex is necessary for sensitivity to the PARP inhibitor olaparib. {ECO:0000269|PubMed:29656893}.	DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]		chromatin [GO:0000785]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:29656893}. Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle. {ECO:0000269|PubMed:29656893}.
Q6ZP29	reviewed	LAAT1_HUMAN	Lysosomal amino acid transporter 1 homolog (PQ-loop repeat-containing protein 2) (Solute carrier family 66 member 1)	SLC66A1 PQLC2	Homo sapiens (Human)	291	FUNCTION: Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. {ECO:0000269|PubMed:22822152, ECO:0000269|PubMed:23169667}.	MISCELLANEOUS: May play a role in the export from lysosomes of cysteamine-cysteine mixed disulfide (MxD), the product formed upon treatment by cysteamine of patients with cystinosis, a disease characterized by the accumulation of cystine in the lysosomes. {ECO:0000305|PubMed:23169667}.	intracellular amino acid homeostasis [GO:0080144]; L-arginine transmembrane transport [GO:1903826]; lysine transport [GO:0015819]; transmembrane transport [GO:0055085]	intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; organelle membrane [GO:0031090]	basic amino acid transmembrane transporter activity [GO:0015174]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]	intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; organelle membrane [GO:0031090]; basic amino acid transmembrane transporter activity [GO:0015174]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; intracellular amino acid homeostasis [GO:0080144]; L-arginine transmembrane transport [GO:1903826]; lysine transport [GO:0015819]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:22822152}; Multi-pass membrane protein {ECO:0000269|PubMed:22822152}.
Q6ZP80	reviewed	TM182_HUMAN	Transmembrane protein 182	TMEM182 UNQ6974/PRO21957	Homo sapiens (Human)	229	FUNCTION: Negatively regulates myogenesis and skeletal muscle regeneration via its association with ITGB1 (By similarity). Modulates ITGB1 activation by decreasing ITGB1-LAMB1 interaction and inhibiting ITGB1-mediated intracellular signaling during myogenesis (By similarity). {ECO:0000250|UniProtKB:A0A1D5NY17}.		muscle organ development [GO:0007517]; myotube cell development involved in skeletal muscle regeneration [GO:0014906]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myoblast fusion [GO:1901740]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; muscle organ development [GO:0007517]; myotube cell development involved in skeletal muscle regeneration [GO:0014906]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myoblast fusion [GO:1901740]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A0A1D5NY17}; Multi-pass membrane protein {ECO:0000255}.
Q6ZP82	reviewed	CC141_HUMAN	Coiled-coil domain-containing protein 141 (Coiled-coil protein associated with myosin II and DISC1)	CCDC141 CAMDI	Homo sapiens (Human)	1530	FUNCTION: Plays a critical role in cortical radial and GnRH neurons migration during brain development. Regulates cortical radial migration by negatively controlling the activity of histone deacetylase 6 (HDAC6) and promotes centrosome maturation. CAMDI is required for dilation formation of cortical neurons during radial migration. Plays a critical role in learning and memory performance through regulation of AMPA-selective glutamate receptors (AMPARs) cell surface expression in competition with KIBRA. {ECO:0000250|UniProtKB:E9Q8Q6}.		centrosome localization [GO:0051642]; cerebral cortex radially oriented cell migration [GO:0021799]	centrosome [GO:0005813]; cytoplasm [GO:0005737]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; centrosome localization [GO:0051642]; cerebral cortex radially oriented cell migration [GO:0021799]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:E9Q8Q6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:E9Q8Q6}. Note=Co-localized with DISC1 at/around the centrosome. Localizes to the centrosome, at least in part, in a DISC1-dependent manner. Accumulates and oscillates at the dilation in cortical neurons during migration. CAMDI protein level is stabilized at the G1 phase and destabilized at the G2 /M phase. {ECO:0000250|UniProtKB:E9Q8Q6}.
Q6ZPD8	reviewed	DG2L6_HUMAN	Diacylglycerol O-acyltransferase 2-like protein 6 (EC 2.3.1.-) (Diacylglycerol O-acyltransferase candidate 3) (hDC3)	DGAT2L6 DC3	Homo sapiens (Human)	337	FUNCTION: Diglyceride acyltransferase that uses fatty acyl-CoA as substrate (PubMed:15671038). Particularly active with oleate as a substrate (PubMed:15671038). Has no wax synthase activity to produce wax esters (PubMed:15671038). Able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000269|PubMed:15671038, ECO:0000269|PubMed:28420705}.		acylglycerol acyl-chain remodeling [GO:0036155]; lipid metabolic process [GO:0006629]; monoacylglycerol biosynthetic process [GO:0006640]	endoplasmic reticulum membrane [GO:0005789]	diacylglycerol O-acyltransferase activity [GO:0004144]; O-acyltransferase activity [GO:0008374]	endoplasmic reticulum membrane [GO:0005789]; diacylglycerol O-acyltransferase activity [GO:0004144]; O-acyltransferase activity [GO:0008374]; acylglycerol acyl-chain remodeling [GO:0036155]; lipid metabolic process [GO:0006629]; monoacylglycerol biosynthetic process [GO:0006640]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000255}.
Q6ZQN7	reviewed	SO4C1_HUMAN	Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (OATP-H) (Organic anion transporter M1) (OATP-M1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20)	SLCO4C1 OATP4C1 OATPX SLC21A20	Homo sapiens (Human)	724	FUNCTION: Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:20610891). Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604). Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:19129463). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:19129463). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker) (PubMed:30865704). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (PubMed:30865704, PubMed:32642843). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity). {ECO:0000250|UniProtKB:Q71MB6, ECO:0000250|UniProtKB:Q8BGD4, ECO:0000269|PubMed:14993604, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20610891, ECO:0000269|PubMed:30865704, ECO:0000269|PubMed:32642843}.	MISCELLANEOUS: SLCO4C1-mediated digoxin uptake is inhibited by digoxin itself and related compounds such as ouabain, digitoxin and digoxigenin. {ECO:0000269|PubMed:14993604}.	cell differentiation [GO:0030154]; monoatomic ion transport [GO:0006811]; sodium-independent organic anion transport [GO:0043252]; spermatogenesis [GO:0007283]	azurophil granule membrane [GO:0035577]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	organic anion transmembrane transporter activity [GO:0008514]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]	azurophil granule membrane [GO:0035577]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; organic anion transmembrane transporter activity [GO:0008514]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; cell differentiation [GO:0030154]; monoatomic ion transport [GO:0006811]; sodium-independent organic anion transport [GO:0043252]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:30865704}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q71MB6}. Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney. {ECO:0000250|UniProtKB:Q71MB6, ECO:0000269|PubMed:30865704}.
Q6ZQW0	reviewed	I23O2_HUMAN	Indoleamine 2,3-dioxygenase 2 (IDO-2) (EC 1.13.11.-) (Indoleamine 2,3-dioxygenase-like protein 1) (Indoleamine-pyrrole 2,3-dioxygenase-like protein 1)	IDO2 INDOL1	Homo sapiens (Human)	407	FUNCTION: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885). {ECO:0000269|PubMed:17671174, ECO:0000303|PubMed:25691885}.	MISCELLANEOUS: IDO1 and IDO2 are 2 distinct enzymes which catalyze the same reaction. IDO2 affinity for tryptophan is much lower than that of IDO1. 50 % of Caucasians harbor polymorphisms which abolish IDO2 enzymatic activity. IDO2 is expressed in human tumors in an inactive form: tryptophan degradation is entirely provided by IDO1 in these cells (PubMed:18418598). IDO2 may play a role as a negative regulator of IDO1 by competing for heme-binding with IDO1 (PubMed:25394548). Low efficiency IDO2 enzymes have been conserved throughout vertebrate evolution, whereas higher efficiency IDO1 enzymes are dispensable in many lower vertebrate lineages (PubMed:25950090). IDO1 may have arisen by gene duplication of a more ancient proto-IDO gene before the divergence of marsupial and eutherian (placental) mammals. {ECO:0000269|PubMed:18418598, ECO:0000269|PubMed:25394548, ECO:0000269|PubMed:25950090}.	'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; immune system process [GO:0002376]; tryptophan catabolic process to kynurenine [GO:0019441]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	heme binding [GO:0020037]; indoleamine 2,3-dioxygenase activity [GO:0033754]; metal ion binding [GO:0046872]; tryptophan 2,3-dioxygenase activity [GO:0004833]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; heme binding [GO:0020037]; indoleamine 2,3-dioxygenase activity [GO:0033754]; metal ion binding [GO:0046872]; tryptophan 2,3-dioxygenase activity [GO:0004833]; 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; immune system process [GO:0002376]; tryptophan catabolic process to kynurenine [GO:0019441]	
Q6ZQX7	reviewed	LIAT1_HUMAN	Protein LIAT1 (Ligand of ATE1 protein)	LIAT1 C17orf97	Homo sapiens (Human)	453	FUNCTION: Participates in nucleolar liquid-liquid phase separation (LLPS) through its N-terminal intrinsically disordered region (IDR). May be involved in ATE1-mediated N-terminal arginylation. {ECO:0000250|UniProtKB:Q810M6}.		non-membrane-bounded organelle assembly [GO:0140694]; protein arginylation [GO:0016598]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	molecular condensate scaffold activity [GO:0140693]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; molecular condensate scaffold activity [GO:0140693]; non-membrane-bounded organelle assembly [GO:0140694]; protein arginylation [GO:0016598]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:33443146}. Cytoplasm {ECO:0000269|PubMed:33443146}. Note=Shuttles between the cytoplasm and nucleoplasm, a significant portion localizes to the nucleolus. {ECO:0000269|PubMed:33443146}.
Q6ZQY3	reviewed	GADL1_HUMAN	Acidic amino acid decarboxylase GADL1 (Aspartate 1-decarboxylase) (ADC) (HuADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (HuCSADC) (EC 4.1.1.29) (Glutamate decarboxylase-like protein 1)	GADL1	Homo sapiens (Human)	521	FUNCTION: May catalyze the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate. {ECO:0000269|PubMed:23038267}.		carboxylic acid metabolic process [GO:0019752]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	aspartate 1-decarboxylase activity [GO:0004068]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170]; sulfinoalanine decarboxylase activity [GO:0004782]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; aspartate 1-decarboxylase activity [GO:0004068]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170]; sulfinoalanine decarboxylase activity [GO:0004782]; carboxylic acid metabolic process [GO:0019752]	
Q6ZR08	reviewed	DYH12_HUMAN	Dynein axonemal heavy chain 12 (Axonemal beta dynein heavy chain 12) (Axonemal dynein heavy chain 12-like protein) (Axonemal dynein heavy chain 7-like protein) (Ciliary dynein heavy chain 12) (Dynein axonemal heavy chain 7-like) (Dynein heavy chain domain-containing protein 2)	DNAH12 DHC3 DLP12 DNAH12L DNAH7L DNAHC3 DNHD2 HDHC3 HL19	Homo sapiens (Human)	3092	FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.		microtubule-based movement [GO:0007018]	axonemal dynein complex [GO:0005858]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]	axonemal dynein complex [GO:0005858]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}.
Q6ZR37	reviewed	PKHG7_HUMAN	Pleckstrin homology domain-containing family G member 7 (PH domain-containing family G member 7)	PLEKHG7 C12orf74	Homo sapiens (Human)	691			Rho protein signal transduction [GO:0007266]		guanyl-nucleotide exchange factor activity [GO:0005085]	guanyl-nucleotide exchange factor activity [GO:0005085]; Rho protein signal transduction [GO:0007266]	
Q6ZRF8	reviewed	RN207_HUMAN	RING finger protein 207	RNF207 C1orf188	Homo sapiens (Human)	634	FUNCTION: Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. {ECO:0000269|PubMed:25281747}.		cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207]	perinuclear region of cytoplasm [GO:0048471]	Hsp70 protein binding [GO:0030544]; protein-folding chaperone binding [GO:0051087]; transmembrane transporter binding [GO:0044325]; zinc ion binding [GO:0008270]	perinuclear region of cytoplasm [GO:0048471]; Hsp70 protein binding [GO:0030544]; protein-folding chaperone binding [GO:0051087]; transmembrane transporter binding [GO:0044325]; zinc ion binding [GO:0008270]; cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25281747}. Note=Probably located in the endoplasmic reticulum and/or possibly the cis-Golgi apparatus. {ECO:0000269|PubMed:25281747}.
Q6ZRI0	reviewed	OTOG_HUMAN	Otogelin	OTOG OTGN	Homo sapiens (Human)	2925	FUNCTION: Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity). {ECO:0000250}.		L-arabinose metabolic process [GO:0046373]	apical plasma membrane [GO:0016324]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	alpha-L-arabinofuranosidase activity [GO:0046556]	apical plasma membrane [GO:0016324]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; alpha-L-arabinofuranosidase activity [GO:0046556]; L-arabinose metabolic process [GO:0046373]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:O55225}; Peripheral membrane protein {ECO:0000250|UniProtKB:O55225}; Extracellular side {ECO:0000250|UniProtKB:O55225}. Secreted, extracellular space {ECO:0000250|UniProtKB:O55225}. Note=Found in fiber-like structures during the maturation process of the tectorial membrane. {ECO:0000250|UniProtKB:O55225}.
Q6ZRP7	reviewed	QSOX2_HUMAN	Sulfhydryl oxidase 2 (EC 1.8.3.2) (Neuroblastoma-derived sulfhydryl oxidase) (Quiescin Q6-like protein 1)	QSOX2 QSCN6L1 SOXN	Homo sapiens (Human)	698	FUNCTION: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. {ECO:0000269|PubMed:14633699}.		protein folding [GO:0006457]	extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	flavin-dependent sulfhydryl oxidase activity [GO:0016971]; protein disulfide isomerase activity [GO:0003756]	extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; flavin-dependent sulfhydryl oxidase activity [GO:0016971]; protein disulfide isomerase activity [GO:0003756]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:14633699}; Single-pass membrane protein {ECO:0000269|PubMed:14633699}. Secreted {ECO:0000269|PubMed:14633699}. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane.
Q6ZRQ5	reviewed	MMS22_HUMAN	Protein MMS22-like (Methyl methanesulfonate-sensitivity protein 22-like)	MMS22L C6orf167	Homo sapiens (Human)	1243	FUNCTION: Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:21113133, PubMed:26527279, PubMed:27338793, PubMed:29478807). The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:27797818). It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:29478807). Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination (PubMed:27797818, PubMed:29478807). Within the complex, MMS22L acts by binding ssDNA (PubMed:27797818). {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985, ECO:0000269|PubMed:21113133, ECO:0000269|PubMed:26527279, ECO:0000269|PubMed:27338793, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:29478807}.		chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; protein localization to chromatin [GO:0071168]; replication fork processing [GO:0031297]	cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]	single-stranded DNA binding [GO:0003697]	cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; single-stranded DNA binding [GO:0003697]; chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; protein localization to chromatin [GO:0071168]; replication fork processing [GO:0031297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21113133}. Chromosome {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21113133, ECO:0000269|PubMed:27338793, ECO:0000269|PubMed:27797818}. Note=Localizes to DNA damage sites, accumulates at stressed replication forks (PubMed:21055983, PubMed:21055984, PubMed:27797818). Recruited to stalled or collapsed replication forks; directly binds replication protein A complex (RPA/RP-A)-coated single-stranded DNA (ssDNA) (PubMed:27797818). {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:27797818}.
Q6ZRS2	reviewed	SRCAP_HUMAN	Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)	SRCAP KIAA0309	Homo sapiens (Human)	3230	FUNCTION: Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.		chromatin remodeling [GO:0006338]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; Swr1 complex [GO:0000812]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; transcription coactivator activity [GO:0003713]	Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; Swr1 complex [GO:0000812]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; transcription coactivator activity [GO:0003713]; chromatin remodeling [GO:0006338]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549, ECO:0000269|PubMed:10702287}.
Q6ZRV2	reviewed	FA83H_HUMAN	Protein FAM83H	FAM83H	Homo sapiens (Human)	1179	FUNCTION: May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}.		biomineral tissue development [GO:0031214]; intermediate filament cytoskeleton organization [GO:0045104]; positive regulation of cell migration [GO:0030335]; protein localization to cytoskeleton [GO:0044380]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	keratin filament binding [GO:1990254]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; keratin filament binding [GO:1990254]; protein kinase binding [GO:0019901]; biomineral tissue development [GO:0031214]; intermediate filament cytoskeleton organization [GO:0045104]; positive regulation of cell migration [GO:0030335]; protein localization to cytoskeleton [GO:0044380]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23902688}. Note=Colocalizes with keratin filaments. {ECO:0000269|PubMed:23902688}.
Q6ZRY4	reviewed	RBPS2_HUMAN	RNA-binding protein with multiple splicing 2 (RNA binding protein, mRNA processing factor 2)	RBPMS2	Homo sapiens (Human)	209	FUNCTION: RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:25064856). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity). {ECO:0000250|UniProtKB:Q9W6I1, ECO:0000269|PubMed:25064856}.		embryonic digestive tract morphogenesis [GO:0048557]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of smooth muscle cell proliferation [GO:0048661]	cytoplasm [GO:0005737]	identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; embryonic digestive tract morphogenesis [GO:0048557]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of smooth muscle cell proliferation [GO:0048661]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25064856}.
Q6ZS10	reviewed	CL17A_HUMAN	C-type lectin domain family 17, member A (Prolectin)	CLEC17A	Homo sapiens (Human)	378	FUNCTION: Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues. {ECO:0000269|PubMed:19419970}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]	fucose binding [GO:0042806]; identical protein binding [GO:0042802]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; fucose binding [GO:0042806]; identical protein binding [GO:0042802]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=In fibroblasts, expressed on the cell surface. {ECO:0000269|PubMed:19419970}.
Q6ZS17	reviewed	RIPR1_HUMAN	Rho family-interacting cell polarization regulator 1	RIPOR1 FAM65A KIAA1930	Homo sapiens (Human)	1223	FUNCTION: Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}.		cellular response to chemokine [GO:1990869]; cellular response to starvation [GO:0009267]; establishment of Golgi localization [GO:0051683]; negative regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001107]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to Golgi apparatus [GO:0034067]; response to wounding [GO:0009611]; Rho protein signal transduction [GO:0007266]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; vesicle membrane [GO:0012506]	14-3-3 protein binding [GO:0071889]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; vesicle membrane [GO:0012506]; 14-3-3 protein binding [GO:0071889]; cellular response to chemokine [GO:1990869]; cellular response to starvation [GO:0009267]; establishment of Golgi localization [GO:0051683]; negative regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001107]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to Golgi apparatus [GO:0034067]; response to wounding [GO:0009611]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27807006}. Golgi apparatus {ECO:0000269|PubMed:27807006}. Note=Localizes to the podocyte major processes and cell body (By similarity). Colocalized with STK26 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with STK26 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006). {ECO:0000250|UniProtKB:Q68FE6, ECO:0000269|PubMed:27807006}.
Q6ZSA7	reviewed	LRC55_HUMAN	Leucine-rich repeat-containing protein 55 (BK channel auxiliary gamma subunit LRRC55)	LRRC55	Homo sapiens (Human)	298	FUNCTION: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. {ECO:0000269|PubMed:22547800}.		positive regulation of voltage-gated potassium channel activity [GO:1903818]; potassium ion transmembrane transport [GO:0071805]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	potassium channel activator activity [GO:0099104]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; potassium channel activator activity [GO:0099104]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; positive regulation of voltage-gated potassium channel activity [GO:1903818]; potassium ion transmembrane transport [GO:0071805]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q6ZSB9	reviewed	ZBT49_HUMAN	Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509)	ZBTB49 ZNF509	Homo sapiens (Human)	765	FUNCTION: Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. {ECO:0000269|PubMed:25245946}.; FUNCTION: [Isoform 1]: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive). {ECO:0000269|PubMed:25245946}.; FUNCTION: [Isoform 3]: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter. {ECO:0000269|PubMed:25245946}.		cell cycle [GO:0007049]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]; cell cycle [GO:0007049]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:25245946}. Nucleus {ECO:0000269|PubMed:25245946}. Note=Predominantly located in the nucleus. {ECO:0000269|PubMed:25245946}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:25245946}. Nucleus {ECO:0000269|PubMed:25245946}.
Q6ZSG1	reviewed	ARK2C_HUMAN	E3 ubiquitin-protein ligase ARK2C (EC 2.3.2.27) (RING finger protein 165) (RNF165)	ARK2C RNF165	Homo sapiens (Human)	346	FUNCTION: E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. {ECO:0000250|UniProtKB:E9QAU8}.		forelimb morphogenesis [GO:0035136]; innervation [GO:0060384]; motor neuron axon guidance [GO:0008045]; muscle structure development [GO:0061061]; positive regulation of BMP signaling pathway [GO:0030513]; protein catabolic process [GO:0030163]	nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; forelimb morphogenesis [GO:0035136]; innervation [GO:0060384]; motor neuron axon guidance [GO:0008045]; muscle structure development [GO:0061061]; positive regulation of BMP signaling pathway [GO:0030513]; protein catabolic process [GO:0030163]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:E9QAU8}.
Q6ZSJ9	reviewed	SHSA6_HUMAN	Protein shisa-6	SHISA6	Homo sapiens (Human)	500	FUNCTION: Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway. {ECO:0000250|UniProtKB:Q3UH99}.		excitatory chemical synaptic transmission [GO:0098976]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055]	AMPA glutamate receptor complex [GO:0032281]; asymmetric, glutamatergic, excitatory synapse [GO:0098985]; dendritic spine membrane [GO:0032591]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]	ionotropic glutamate receptor binding [GO:0035255]; PDZ domain binding [GO:0030165]	AMPA glutamate receptor complex [GO:0032281]; asymmetric, glutamatergic, excitatory synapse [GO:0098985]; dendritic spine membrane [GO:0032591]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; ionotropic glutamate receptor binding [GO:0035255]; PDZ domain binding [GO:0030165]; excitatory chemical synaptic transmission [GO:0098976]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q3UH99}. Postsynaptic density {ECO:0000250|UniProtKB:Q3UH99}.
Q6ZSM3	reviewed	MOT12_HUMAN	Monocarboxylate transporter 12 (MCT 12) (Creatine transporter 2) (CRT2) (Solute carrier family 16 member 12)	SLC16A12 MCT12	Homo sapiens (Human)	516	FUNCTION: Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution. {ECO:0000269|PubMed:23578822, ECO:0000269|PubMed:26376857, ECO:0000269|PubMed:31784090, ECO:0000269|PubMed:32249133, ECO:0000269|PubMed:32781157}.		creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]; monocarboxylic acid transport [GO:0015718]; transport across blood-brain barrier [GO:0150104]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	creatine transmembrane transporter activity [GO:0005308]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; creatine transmembrane transporter activity [GO:0005308]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; uniporter activity [GO:0015292]; creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]; monocarboxylic acid transport [GO:0015718]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:23578822, ECO:0000269|PubMed:31784090, ECO:0000269|PubMed:32249133}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8BGC3}; Multi-pass membrane protein {ECO:0000255}. Note=Interaction with isoform 2 of BSG is required for its localization to the plasma membrane. {ECO:0000269|PubMed:26376857}.
Q6ZSS7	reviewed	MFSD6_HUMAN	Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog)	MFSD6 MMR2	Homo sapiens (Human)	791			antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]	membrane [GO:0016020]; plasma membrane [GO:0005886]		membrane [GO:0016020]; plasma membrane [GO:0005886]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZSY5	reviewed	PPR3F_HUMAN	Protein phosphatase 1 regulatory subunit 3F (R3F)	PPP1R3F	Homo sapiens (Human)	799	FUNCTION: Glycogen-targeting subunit for protein phosphatase 1 (PP1). {ECO:0000269|PubMed:21668450}.		regulation of glycogen (starch) synthase activity [GO:2000465]; regulation of glycogen biosynthetic process [GO:0005979]	membrane [GO:0016020]; protein phosphatase type 1 complex [GO:0000164]	glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase binding [GO:0019903]	membrane [GO:0016020]; protein phosphatase type 1 complex [GO:0000164]; glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase binding [GO:0019903]; regulation of glycogen (starch) synthase activity [GO:2000465]; regulation of glycogen biosynthetic process [GO:0005979]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q6ZSZ5	reviewed	ARHGI_HUMAN	Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF)	ARHGEF18 KIAA0521	Homo sapiens (Human)	1361	FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}.		actin cytoskeleton organization [GO:0030036]; negative regulation of stress fiber assembly [GO:0051497]; protein localization to cell-cell junction [GO:0150105]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; actin cytoskeleton organization [GO:0030036]; negative regulation of stress fiber assembly [GO:0051497]; protein localization to cell-cell junction [GO:0150105]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15558029}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15558029}. Cell membrane {ECO:0000269|PubMed:29601110}. Apical cell membrane {ECO:0000269|PubMed:22006950}. Note=In unactivated eosinophils, distributed around the cell periphery in the perimembranous region (PubMed:29601110). In activated eosinophils, relocates to the tip of the nucleopod, a membrane structure formed during activation when the nucleus moves to one end of the cell, and is also concentrated in membrane protrusions at the opposite end of the cell (PubMed:29601110). Localizes to the apical cell membrane in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:29601110}.
Q6ZSZ6	reviewed	TSH1_HUMAN	Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33)	TSHZ1 SDCCAG33 TSH1	Homo sapiens (Human)	1077	FUNCTION: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}.		anterior/posterior pattern specification [GO:0009952]; middle ear morphogenesis [GO:0042474]; regulation of transcription by RNA polymerase II [GO:0006357]; soft palate development [GO:0060023]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; anterior/posterior pattern specification [GO:0009952]; middle ear morphogenesis [GO:0042474]; regulation of transcription by RNA polymerase II [GO:0006357]; soft palate development [GO:0060023]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZT12	reviewed	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3 (EC 2.3.2.27) (N-recognin-3) (RING-type E3 ubiquitin transferase UBR3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650)	UBR3 KIAA2024 ZNF650	Homo sapiens (Human)	1888	FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610). {ECO:0000250|UniProtKB:Q5U430, ECO:0000269|PubMed:27331610}.		embryo development ending in birth or egg hatching [GO:0009792]; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]; sensory perception of smell [GO:0007608]; suckling behavior [GO:0001967]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596]	cytoplasm [GO:0005737]; membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; embryo development ending in birth or egg hatching [GO:0009792]; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]; sensory perception of smell [GO:0007608]; suckling behavior [GO:0001967]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZT21	reviewed	TMPPE_HUMAN	Transmembrane protein with metallophosphoesterase domain (EC 3.1.-.-)	TMPPE	Homo sapiens (Human)	453				membrane [GO:0016020]	hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	membrane [GO:0016020]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZT62	reviewed	BGIN_HUMAN	Bargin (Chimeric SH3BP1-PDXP protein)	BARGIN	Homo sapiens (Human)	677	FUNCTION: GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and K-48 polyubiquitin chains. {ECO:0000269|PubMed:23223568}.	MISCELLANEOUS: [Isoform Long BGIN]: Based on a naturally occurring readthrough transcript which produces a SH3BP1-PDXP fusion protein. Translation initiation occurs at a non-canonical CUG codon. {ECO:0000269|PubMed:23223568}.; MISCELLANEOUS: [Isoform Short BGIN]: Produced by alternative initiation at Met-73 of isoform long BGIN. {ECO:0000269|PubMed:23223568}.	negative regulation of small GTPase mediated signal transduction [GO:0051058]; positive regulation of GTPase activity [GO:0043547]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of Rac protein signal transduction [GO:0035020]; signal transduction [GO:0007165]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; linear polyubiquitin binding [GO:1990450]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; linear polyubiquitin binding [GO:1990450]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; positive regulation of GTPase activity [GO:0043547]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of Rac protein signal transduction [GO:0035020]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23223568}; Peripheral membrane protein {ECO:0000305|PubMed:23223568}. Cytoplasm, cytosol {ECO:0000269|PubMed:23223568}. Note=Localization to membranes is increased by binding of poly-ubiquitin chains (PubMed:23223568). Enriched in tangle aggregates in cells of Alzheimer's disease brain (PubMed:23223568). {ECO:0000269|PubMed:23223568}.
Q6ZT89	reviewed	S2548_HUMAN	Solute carrier family 25 member 48	SLC25A48	Homo sapiens (Human)	311				mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	transmembrane transporter activity [GO:0022857]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q6ZT98	reviewed	TTLL7_HUMAN	Tubulin polyglutamylase TTLL7 (EC 6.3.2.-) (Testis development protein NYD-SP30) (Tubulin--tyrosine ligase-like protein 7)	TTLL7	Homo sapiens (Human)	887	FUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:16901895, PubMed:25959773). Mediates both ATP-dependent initiation and elongation steps of the polyglutamylation reaction (PubMed:16901895, PubMed:25959773). Preferentially modifies the beta-tubulin tail over an alpha-tail (PubMed:16901895, PubMed:25959773). Competes with monoglycylase TTLL3 for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (By similarity). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity). {ECO:0000250|UniProtKB:A4Q9F0, ECO:0000250|UniProtKB:F7E540, ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:25959773}.		cell differentiation [GO:0030154]; microtubule cytoskeleton organization [GO:0000226]; nervous system development [GO:0007399]; protein polyglutamylation [GO:0018095]	cilium [GO:0005929]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; perikaryon [GO:0043204]	alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	cilium [GO:0005929]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; perikaryon [GO:0043204]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]; cell differentiation [GO:0030154]; microtubule cytoskeleton organization [GO:0000226]; nervous system development [GO:0007399]; protein polyglutamylation [GO:0018095]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:A4Q9F0}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A4Q9F0}. Cell projection, dendrite {ECO:0000250|UniProtKB:A4Q9F0}. Perikaryon {ECO:0000250|UniProtKB:A4Q9F0}. Note=In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon. {ECO:0000250|UniProtKB:A4Q9F0}.
Q6ZTN6	reviewed	AN13D_HUMAN	Ankyrin repeat domain-containing protein 13D	ANKRD13D	Homo sapiens (Human)	605	FUNCTION: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269|PubMed:22298428}.		negative regulation of receptor internalization [GO:0002091]	cytoplasm [GO:0005737]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	ubiquitin-dependent protein binding [GO:0140036]	cytoplasm [GO:0005737]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ubiquitin-dependent protein binding [GO:0140036]; negative regulation of receptor internalization [GO:0002091]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22298428}. Late endosome {ECO:0000269|PubMed:22298428}. Note=Interaction with EGFR may enhance association with the cell membrane.
Q6ZTQ4	reviewed	CDHR3_HUMAN	Cadherin-related family member 3 (Cadherin-like protein 28)	CDHR3 CDH28	Homo sapiens (Human)	885	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.; FUNCTION: (Microbial infection) Acts as a receptor for rhinovirus C. {ECO:0000269|PubMed:25848009}.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synaptic transmission, glutamatergic [GO:0035249]	adherens junction [GO:0005912]; axon terminus [GO:0043679]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; virus receptor activity [GO:0001618]	adherens junction [GO:0005912]; axon terminus [GO:0043679]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; virus receptor activity [GO:0001618]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24241537}; Single-pass type I membrane protein {ECO:0000250}.
Q6ZTR5	reviewed	CFA47_HUMAN	Cilia- and flagella-associated protein 47	CFAP47 CHDC2 CXorf22 CXorf30 CXorf59	Homo sapiens (Human)	3187	FUNCTION: Plays a role in flagellar formation and sperm motility. {ECO:0000269|PubMed:33472045}.		cilium assembly [GO:0060271]; sperm axoneme assembly [GO:0007288]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm connecting piece [GO:0097224]		cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm connecting piece [GO:0097224]; cilium assembly [GO:0060271]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000269|PubMed:33472045}.
Q6ZU15	reviewed	SEP14_HUMAN	Septin-14	SEPTIN14 SEPT14	Homo sapiens (Human)	432	FUNCTION: Filament-forming cytoskeletal GTPase (Probable). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments (PubMed:33228246). {ECO:0000250|UniProtKB:Q9DA97, ECO:0000269|PubMed:33228246, ECO:0000305}.		cytoskeleton-dependent cytokinesis [GO:0061640]; neuron migration [GO:0001764]; protein localization to perinuclear region of cytoplasm [GO:1905719]; spermatid development [GO:0007286]	acrosomal vesicle [GO:0001669]; axon [GO:0030424]; cell division site [GO:0032153]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; microtubule cytoskeleton [GO:0015630]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; septin complex [GO:0031105]; septin ring [GO:0005940]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]	acrosomal vesicle [GO:0001669]; axon [GO:0030424]; cell division site [GO:0032153]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; microtubule cytoskeleton [GO:0015630]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; septin complex [GO:0031105]; septin ring [GO:0005940]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]; cytoskeleton-dependent cytokinesis [GO:0061640]; neuron migration [GO:0001764]; protein localization to perinuclear region of cytoplasm [GO:1905719]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17922164}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17922164, ECO:0000269|PubMed:31450874}. Cell projection, axon {ECO:0000250|UniProtKB:Q9DA97}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9DA97}. Perikaryon {ECO:0000250|UniProtKB:Q9DA97}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9DA97}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:32249155}. Note=Colocalizes with actin stress fibers (PubMed:17922164). Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity). {ECO:0000250|UniProtKB:Q9DA97, ECO:0000269|PubMed:17922164}.
Q6ZU35	reviewed	CRACD_HUMAN	Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics)	CRACD CRAD KIAA1211	Homo sapiens (Human)	1233	FUNCTION: Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}.		epithelial structure maintenance [GO:0010669]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of actin filament polymerization [GO:0030838]	cytosol [GO:0005829]		cytosol [GO:0005829]; epithelial structure maintenance [GO:0010669]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of actin filament polymerization [GO:0030838]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:30361697}.
Q6ZU52	reviewed	K0408_HUMAN	Uncharacterized protein KIAA0408	KIAA0408	Homo sapiens (Human)	694							
Q6ZU64	reviewed	CFA65_HUMAN	Cilia- and flagella-associated protein 65 (Coiled-coil domain-containing protein 108)	CFAP65 CCDC108	Homo sapiens (Human)	1925	FUNCTION: Plays a role in flagellar formation and sperm motility. {ECO:0000305|PubMed:33472045}.		flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]	RNA binding [GO:0003723]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; RNA binding [GO:0003723]; flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:33472045}; Single-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:31413122, ECO:0000269|PubMed:33472045}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:31413122}. Note=Expressed in flagella midpiece and acrosome of mature spermatozoa. {ECO:0000269|PubMed:31413122, ECO:0000269|PubMed:33472045}.
Q6ZU80	reviewed	CE128_HUMAN	Centrosomal protein of 128 kDa (Cep128)	CEP128 C14orf145 C14orf61	Homo sapiens (Human)	1094		MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	protein localization [GO:0008104]	centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; spindle pole [GO:0000922]		centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; spindle pole [GO:0000922]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:21399614}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:21399614}. Note=Associates with the mother centriole.
Q6ZUI0	reviewed	TPRG1_HUMAN	Tumor protein p63-regulated gene 1 protein (Protein FAM79B)	TPRG1 FAM79B	Homo sapiens (Human)	275				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8CB49}.
Q6ZUJ8	reviewed	BCAP_HUMAN	Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1)	PIK3AP1 BCAP	Homo sapiens (Human)	805	FUNCTION: Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}.		positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of inflammatory response [GO:0050727]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162]	cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; signaling receptor binding [GO:0005102]	cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; signaling receptor binding [GO:0005102]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of inflammatory response [GO:0050727]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q6ZUM4	reviewed	RHG27_HUMAN	Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20)	ARHGAP27 CAMGAP1 SH3D20 PP905	Homo sapiens (Human)	889	FUNCTION: Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}.		positive regulation of GTPase activity [GO:0043547]; receptor-mediated endocytosis [GO:0006898]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]; positive regulation of GTPase activity [GO:0043547]; receptor-mediated endocytosis [GO:0006898]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q6ZUT1	reviewed	NKAP1_HUMAN	Uncharacterized protein NKAPD1 (NKAP domain containing protein 1)	NKAPD1 C11orf57	Homo sapiens (Human)	292					identical protein binding [GO:0042802]	identical protein binding [GO:0042802]	
Q6ZUT3	reviewed	FRMD7_HUMAN	FERM domain-containing protein 7	FRMD7	Homo sapiens (Human)	714	FUNCTION: Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. {ECO:0000250|UniProtKB:A2AD83, ECO:0000269|PubMed:17013395, ECO:0000269|PubMed:23946638}.	MISCELLANEOUS: [Isoform 2]: May play a role during neuronal differentiation and development. Shares a similar tissue distribution, co-localize with, and interact with isoform 1 in NT2 cells. {ECO:0000305}.	negative regulation of stress fiber assembly [GO:0051497]; nervous system development [GO:0007399]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; regulation of neuron projection development [GO:0010975]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular space [GO:0005615]; growth cone [GO:0030426]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular space [GO:0005615]; growth cone [GO:0030426]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; negative regulation of stress fiber assembly [GO:0051497]; nervous system development [GO:0007399]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; regulation of neuron projection development [GO:0010975]	SUBCELLULAR LOCATION: Cell projection, neuron projection {ECO:0000250|UniProtKB:A2AD83}. Cell projection, growth cone {ECO:0000250|UniProtKB:A2AD83}. Note=In undifferentiated neurons, located in the actin-rich regions of the cell body. In differentiated neurons, located in the actin-rich regions of the cell body and primary neurite processes but is almost absent from secondary extensions arising from the primary neurite. Also found at the actin-rich distal end of growth cones (By similarity). {ECO:0000250|UniProtKB:A2AD83}.
Q6ZUX7	reviewed	LHPL2_HUMAN	LHFPL tetraspan subfamily member 2 protein (Lipoma HMGIC fusion partner-like 2 protein)	LHFPL2 KIAA0206	Homo sapiens (Human)	228	FUNCTION: Plays a role in female and male fertility. Involved in distal reproductive tract development. {ECO:0000250|UniProtKB:Q8BGA2}.		development of primary female sexual characteristics [GO:0046545]; development of primary male sexual characteristics [GO:0046546]; positive regulation of fertilization [GO:1905516]; single fertilization [GO:0007338]	membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]		membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; development of primary female sexual characteristics [GO:0046545]; development of primary male sexual characteristics [GO:0046546]; positive regulation of fertilization [GO:1905516]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZV29	reviewed	PLPL7_HUMAN	Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (EC 3.1.1.5)	PNPLA7 C9orf111	Homo sapiens (Human)	1317	FUNCTION: Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine. Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0). {ECO:0000250|UniProtKB:A2AJ88}.		phosphatidylcholine catabolic process [GO:0034638]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]	lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; phosphatidylcholine catabolic process [GO:0034638]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A2AJ88}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:A2AJ88}. Lipid droplet {ECO:0000250|UniProtKB:A2AJ88}.
Q6ZV65	reviewed	FA47E_HUMAN	Protein FAM47E	FAM47E	Homo sapiens (Human)	393	FUNCTION: Promotes histone methylation by localizing the arginine methyltransferase PRMT5 to chromatin. {ECO:0000269|PubMed:33376131}.		protein localization to chromatin [GO:0071168]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	enzyme activator activity [GO:0008047]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; enzyme activator activity [GO:0008047]; protein localization to chromatin [GO:0071168]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33376131}. Chromosome {ECO:0000269|PubMed:33376131}. Cytoplasm {ECO:0000269|PubMed:33376131}. Note=Localizes to promoter regions of PRMT5 target genes. {ECO:0000269|PubMed:33376131}.
Q6ZV73	reviewed	FGD6_HUMAN	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24)	FGD6 KIAA1362 ZFYVE24	Homo sapiens (Human)	1430	FUNCTION: May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.		actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726]	guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}.
Q6ZVD7	reviewed	STOX1_HUMAN	Storkhead-box protein 1 (Winged-helix domain-containing protein)	STOX1 C10orf24	Homo sapiens (Human)	989	FUNCTION: Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity). {ECO:0000250|UniProtKB:B2RQL2, ECO:0000269|PubMed:24738702}.; FUNCTION: [Isoform A]: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177). {ECO:0000269|PubMed:22253775, ECO:0000269|PubMed:22995177}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to nitrosative stress [GO:0071500]; inner ear development [GO:0048839]; negative regulation of gene expression [GO:0010629]; positive regulation of cyclin-dependent protein kinase activity [GO:1904031]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of gene expression [GO:0010628]; positive regulation of otic vesicle morphogenesis [GO:1904120]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of gene expression [GO:0010468]; regulation of mitochondrial DNA metabolic process [GO:1901858]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of response to oxidative stress [GO:1902882]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to nitrosative stress [GO:0071500]; inner ear development [GO:0048839]; negative regulation of gene expression [GO:0010629]; positive regulation of cyclin-dependent protein kinase activity [GO:1904031]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of gene expression [GO:0010628]; positive regulation of otic vesicle morphogenesis [GO:1904120]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of gene expression [GO:0010468]; regulation of mitochondrial DNA metabolic process [GO:1901858]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of response to oxidative stress [GO:1902882]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]	SUBCELLULAR LOCATION: [Isoform A]: Cytoplasm {ECO:0000269|PubMed:22253775}. Nucleus {ECO:0000269|PubMed:22253775}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22253775}. Note=In epithelial cells, diffusely expressed in the cytoplasm, particularly in peri-membrane cortical regions (By similarity). Concentrated at centrosomes during metaphase (PubMed:22253775). {ECO:0000250|UniProtKB:B2RQL2, ECO:0000269|PubMed:22253775}.; SUBCELLULAR LOCATION: [Isoform B]: Nucleus.; SUBCELLULAR LOCATION: [Isoform C]: Nucleus, nucleolus.
Q6ZVD8	reviewed	PHLP2_HUMAN	PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)	PHLPP2 KIAA0931 PHLPPL	Homo sapiens (Human)	1323	FUNCTION: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}.		hippocampus development [GO:0021766]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment membrane [GO:0042622]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment membrane [GO:0042622]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; hippocampus development [GO:0021766]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.
Q6ZVE7	reviewed	GOT1A_HUMAN	Vesicle transport protein GOT1A (Golgi transport 1 homolog A) (hGOT1b)	GOLT1A GOT1B	Homo sapiens (Human)	132	FUNCTION: May be involved in fusion of ER-derived transport vesicles with the Golgi complex. {ECO:0000269|PubMed:10406798}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; trans-Golgi network [GO:0005802]		cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; trans-Golgi network [GO:0005802]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q6ZVK8	reviewed	NUD18_HUMAN	8-oxo-dGDP phosphatase NUDT18 (EC 3.6.1.58) (2-hydroxy-dADP phosphatase) (7,8-dihydro-8-oxoguanine phosphatase) (MutT homolog 3) (Nucleoside diphosphate-linked moiety X motif 18) (Nudix motif 18)	NUDT18 MTH3	Homo sapiens (Human)	323	FUNCTION: Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. {ECO:0000269|PubMed:22556419}.		dADP catabolic process [GO:0046057]; dGDP catabolic process [GO:0046067]; GDP catabolic process [GO:0046712]; nucleobase-containing small molecule metabolic process [GO:0055086]	cytosol [GO:0005829]	8-hydroxy-dADP phosphatase activity [GO:0044717]; 8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; 8-hydroxy-dADP phosphatase activity [GO:0044717]; 8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; magnesium ion binding [GO:0000287]; dADP catabolic process [GO:0046057]; dGDP catabolic process [GO:0046067]; GDP catabolic process [GO:0046712]; nucleobase-containing small molecule metabolic process [GO:0055086]	
Q6ZVM7	reviewed	TM1L2_HUMAN	TOM1-like protein 2 (Target of Myb-like protein 2)	TOM1L2	Homo sapiens (Human)	507	FUNCTION: Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}.		negative regulation of mitotic nuclear division [GO:0045839]; protein transport [GO:0015031]; signal transduction [GO:0007165]	endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]	endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; negative regulation of mitotic nuclear division [GO:0045839]; protein transport [GO:0015031]; signal transduction [GO:0007165]	
Q6ZVN8	reviewed	RGMC_HUMAN	Hemojuvelin (Hemochromatosis type 2 protein) (Hemojuvelin BMP coreceptor) (RGM domain family member C)	HJV HFE2 RGMC	Homo sapiens (Human)	426	FUNCTION: Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed:18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed:18976966). {ECO:0000269|PubMed:18976966}.		activin receptor signaling pathway [GO:0032924]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoprocessing [GO:0016540]; transcription by RNA polymerase II [GO:0006366]	BMP receptor complex [GO:0070724]; cell surface [GO:0009986]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; side of membrane [GO:0098552]	BMP binding [GO:0036122]; coreceptor activity [GO:0015026]; signaling receptor binding [GO:0005102]; transferrin receptor binding [GO:1990459]	BMP receptor complex [GO:0070724]; cell surface [GO:0009986]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; side of membrane [GO:0098552]; BMP binding [GO:0036122]; coreceptor activity [GO:0015026]; signaling receptor binding [GO:0005102]; transferrin receptor binding [GO:1990459]; activin receptor signaling pathway [GO:0032924]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoprocessing [GO:0016540]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Also released in the extracellular space. {ECO:0000269|PubMed:25156943}.
Q6ZVT0	reviewed	TTL10_HUMAN	Inactive polyglycylase TTLL10 (Tubulin--tyrosine ligase-like protein 10)	TTLL10	Homo sapiens (Human)	673	FUNCTION: Inactive polyglycylase. {ECO:0000269|PubMed:19524510}.		protein modification process [GO:0036211]	cytosol [GO:0005829]	ATP binding [GO:0005524]; protein-glycine ligase activity [GO:0070735]	cytosol [GO:0005829]; ATP binding [GO:0005524]; protein-glycine ligase activity [GO:0070735]; protein modification process [GO:0036211]	
Q6ZW31	reviewed	SYDE1_HUMAN	Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1)	SYDE1	Homo sapiens (Human)	735	FUNCTION: GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}.		actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; cell migration [GO:0016477]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of cytoskeleton organization [GO:0051493]; regulation of Ras protein signal transduction [GO:0046578]; signal transduction [GO:0007165]	synaptic membrane [GO:0097060]	GTPase activator activity [GO:0005096]; GTPase regulator activity [GO:0030695]	synaptic membrane [GO:0097060]; GTPase activator activity [GO:0005096]; GTPase regulator activity [GO:0030695]; actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; cell migration [GO:0016477]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of cytoskeleton organization [GO:0051493]; regulation of Ras protein signal transduction [GO:0046578]; signal transduction [GO:0007165]	
Q6ZW49	reviewed	PAXI1_HUMAN	PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)	PAXIP1 PAXIP1L PTIP CAGF28	Homo sapiens (Human)	1069	FUNCTION: Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned (By similarity). Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (By similarity). {ECO:0000250|UniProtKB:Q6NZQ4, ECO:0000269|PubMed:14576432, ECO:0000269|PubMed:15456759, ECO:0000269|PubMed:17690115, ECO:0000269|PubMed:17925232, ECO:0000269|PubMed:18353733, ECO:0000269|PubMed:20088963, ECO:0000269|PubMed:23727112}.		adipose tissue development [GO:0060612]; chorion development [GO:0060717]; chromatin remodeling [GO:0006338]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; endothelial cell migration [GO:0043542]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of isotype switching [GO:0045830]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of cell cycle G2/M phase transition [GO:1902749]; response to ionizing radiation [GO:0010212]; vasculogenesis [GO:0001570]	chromosome [GO:0005694]; histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		chromosome [GO:0005694]; histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; adipose tissue development [GO:0060612]; chorion development [GO:0060717]; chromatin remodeling [GO:0006338]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; endothelial cell migration [GO:0043542]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of isotype switching [GO:0045830]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of cell cycle G2/M phase transition [GO:1902749]; response to ionizing radiation [GO:0010212]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250|UniProtKB:Q6NZQ4}. Chromosome {ECO:0000269|PubMed:15456759, ECO:0000269|PubMed:17690115}. Note=Localizes to DNA damage foci upon ionizing radiation. {ECO:0000269|PubMed:15456759, ECO:0000269|PubMed:17690115}.
Q6ZW61	reviewed	BBS12_HUMAN	Bardet-Biedl syndrome 12 protein	BBS12 C4orf24	Homo sapiens (Human)	710	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). Involved in adipogenic differentiation (PubMed:19190184). {ECO:0000269|PubMed:19190184, ECO:0000269|PubMed:20080638}.	MISCELLANEOUS: Adipocytes derived from BBS-patients' dermal fibroblasts in culture exhibit higher propensity for fat accumulation when compared to controls. This strongly suggests that a peripheral primary dysfunction of adipogenesis participates in the pathogenesis of obesity in BBS.	chaperone-mediated protein complex assembly [GO:0051131]; eating behavior [GO:0042755]; fat cell differentiation [GO:0045444]; intraciliary transport [GO:0042073]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of stem cell differentiation [GO:2000737]; photoreceptor cell maintenance [GO:0045494]; stem cell differentiation [GO:0048863]	cilium [GO:0005929]	ATP binding [GO:0005524]	cilium [GO:0005929]; ATP binding [GO:0005524]; chaperone-mediated protein complex assembly [GO:0051131]; eating behavior [GO:0042755]; fat cell differentiation [GO:0045444]; intraciliary transport [GO:0042073]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of stem cell differentiation [GO:2000737]; photoreceptor cell maintenance [GO:0045494]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:19190184}. Note=Located within the basal body of the primary cilium of differentiating preadipocytes. {ECO:0000269|PubMed:19190184}.
Q6ZW76	reviewed	ANKS3_HUMAN	Ankyrin repeat and SAM domain-containing protein 3	ANKS3 KIAA1977	Homo sapiens (Human)	656	FUNCTION: May be involved in vasopressin signaling in the kidney. {ECO:0000250|UniProtKB:Q9CZK6}.			cilium [GO:0005929]; cytoplasm [GO:0005737]		cilium [GO:0005929]; cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q9CZK6}. Cytoplasm {ECO:0000250|UniProtKB:Q9CZK6}.
Q6ZWH5	reviewed	NEK10_HUMAN	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A-related kinase 10) (NimA-related protein kinase 10)	NEK10	Homo sapiens (Human)	1172	FUNCTION: Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport (PubMed:31959991). {ECO:0000269|PubMed:20956560, ECO:0000269|PubMed:31959991}.		mucociliary clearance [GO:0120197]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein autophosphorylation [GO:0031954]; protein phosphorylation [GO:0006468]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of ERK1 and ERK2 cascade [GO:0070372]	extracellular region [GO:0005576]; protein kinase complex [GO:1902911]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	extracellular region [GO:0005576]; protein kinase complex [GO:1902911]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; mucociliary clearance [GO:0120197]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein autophosphorylation [GO:0031954]; protein phosphorylation [GO:0006468]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of ERK1 and ERK2 cascade [GO:0070372]	
Q6ZWJ1	reviewed	STXB4_HUMAN	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip)	STXBP4	Homo sapiens (Human)	553	FUNCTION: Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). {ECO:0000250}.		cellular response to type II interferon [GO:0071346]; DNA damage response [GO:0006974]; insulin receptor signaling pathway [GO:0008286]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of keratinocyte proliferation [GO:0010838]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of glucose transmembrane transport [GO:0010827]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]	cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335]; Schaffer collateral - CA1 synapse [GO:0098685]	syntaxin binding [GO:0019905]	cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335]; Schaffer collateral - CA1 synapse [GO:0098685]; syntaxin binding [GO:0019905]; cellular response to type II interferon [GO:0071346]; DNA damage response [GO:0006974]; insulin receptor signaling pathway [GO:0008286]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of keratinocyte proliferation [GO:0010838]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of glucose transmembrane transport [GO:0010827]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q6ZWK4	reviewed	RHEX_HUMAN	Regulator of hemoglobinization and erythroid cell expansion protein (Regulator of human erythroid cell expansion protein)	RHEX C1orf186	Homo sapiens (Human)	172	FUNCTION: Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation (PubMed:25092874). {ECO:0000269|PubMed:25092874}.		cellular response to erythropoietin [GO:0036018]; erythrocyte maturation [GO:0043249]; erythropoietin-mediated signaling pathway [GO:0038162]; positive regulation of erythrocyte differentiation [GO:0045648]	plasma membrane [GO:0005886]	erythropoietin receptor binding [GO:0005128]	plasma membrane [GO:0005886]; erythropoietin receptor binding [GO:0005128]; cellular response to erythropoietin [GO:0036018]; erythrocyte maturation [GO:0043249]; erythropoietin-mediated signaling pathway [GO:0038162]; positive regulation of erythrocyte differentiation [GO:0045648]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25092874}; Single-pass membrane protein {ECO:0000255}.
Q6ZWL3	reviewed	CP4V2_HUMAN	Cytochrome P450 4V2 (Docosahexaenoic acid omega-hydroxylase CYP4V2) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)	CYP4V2	Homo sapiens (Human)	525	FUNCTION: A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs (PubMed:22772592). Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16) (PubMed:19661213). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). {ECO:0000269|PubMed:19661213, ECO:0000269|PubMed:22772592}.		fatty acid omega-oxidation [GO:0010430]; response to stimulus [GO:0050896]; retinoid metabolic process [GO:0001523]; sterol metabolic process [GO:0016125]; visual perception [GO:0007601]	endoplasmic reticulum membrane [GO:0005789]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]	endoplasmic reticulum membrane [GO:0005789]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; fatty acid omega-oxidation [GO:0010430]; response to stimulus [GO:0050896]; retinoid metabolic process [GO:0001523]; sterol metabolic process [GO:0016125]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22772592}; Single-pass membrane protein {ECO:0000305}.
Q6ZWT7	reviewed	MBOA2_HUMAN	Lysophospholipid acyltransferase 2 (LPLAT 2) (EC 2.3.1.-) (1-acylglycerophosphate O-acyltransferase MBOAT2) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase MBOAT2) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine MBOAT2 O-acyltransferase) (EC 2.3.1.n7) (Lysophosphatidic acid acyltransferase) (LPAAT) (Lyso-PA acyltransferase) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 4) (Lyso-PC acyltransferase 4) (Lysophosphatidylethanolamine acyltransferase) (LPEAT) (Lyso-PE acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 2) (O-acyltransferase domain-containing protein 2)	MBOAT2 LPCAT4 OACT2	Homo sapiens (Human)	520	FUNCTION: Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Catalyzes preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS) (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor (PubMed:18772128). May be involved in chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R3I2, ECO:0000269|PubMed:18772128}.		lipid modification [GO:0030258]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid biosynthetic process [GO:0008654]; regulation of chondrocyte differentiation [GO:0032330]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; acyltransferase activity [GO:0016746]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; acyltransferase activity [GO:0016746]; lipid modification [GO:0030258]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid biosynthetic process [GO:0008654]; regulation of chondrocyte differentiation [GO:0032330]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8R3I2}.
Q6ZXV5	reviewed	TMTC3_HUMAN	Protein O-mannosyl-transferase TMTC3 (EC 2.4.1.109) (Protein SMILE) (Transmembrane and TPR repeat-containing protein 3)	TMTC3	Homo sapiens (Human)	915	FUNCTION: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3 (PubMed:28973932). Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response. {ECO:0000269|PubMed:21603654, ECO:0000269|PubMed:28973932}.		positive regulation of proteasomal protein catabolic process [GO:1901800]; protein O-linked mannosylation [GO:0035269]; response to endoplasmic reticulum stress [GO:0034976]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]; positive regulation of proteasomal protein catabolic process [GO:1901800]; protein O-linked mannosylation [GO:0035269]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:21603654}. Note=In odontoblast cultures, it colocalizes with PDIA3 in the endoplasmic reticulum. {ECO:0000269|PubMed:21603654}.
Q6ZYL4	reviewed	TF2H5_HUMAN	General transcription factor IIH subunit 5 (General transcription factor IIH polypeptide 5) (TFB5 ortholog) (TFIIH basal transcription factor complex TTD-A subunit) (TFIIH subunit p8)	GTF2H5 C6orf175 TTDA	Homo sapiens (Human)	71	FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. {ECO:0000269|PubMed:15220921}.		cellular response to gamma radiation [GO:0071480]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; transcription initiation at RNA polymerase II promoter [GO:0006367]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]		cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; cellular response to gamma radiation [GO:0071480]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15220921}. Cytoplasm {ECO:0000250|UniProtKB:Q8K2X8}.
Q701N4	reviewed	KRA52_HUMAN	Keratin-associated protein 5-2 (Keratin-associated protein 5-8) (Keratin-associated protein 5.2) (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.2)	KRTAP5-2 KAP5-8 KAP5.2 KRTAP5-8 KRTAP5.2 KRTAP5.8	Homo sapiens (Human)	177	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q702N8	reviewed	XIRP1_HUMAN	Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1)	XIRP1 CMYA1 XIN	Homo sapiens (Human)	1843	FUNCTION: Protects actin filaments from depolymerization. {ECO:0000269|PubMed:15454575}.	MISCELLANEOUS: 'Xin' means 'heart' in Chinese.	actin filament organization [GO:0007015]; negative regulation of protein binding [GO:0032091]	anchoring junction [GO:0070161]	actin filament binding [GO:0051015]; RNA binding [GO:0003723]	anchoring junction [GO:0070161]; actin filament binding [GO:0051015]; RNA binding [GO:0003723]; actin filament organization [GO:0007015]; negative regulation of protein binding [GO:0032091]	SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:15454575}. Note=Colocalizes with actin stress fibers.
Q709C8	reviewed	VP13C_HUMAN	Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C)	VPS13C KIAA1421	Homo sapiens (Human)	3753	FUNCTION: Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}.		Golgi to endosome transport [GO:0006895]; lipid transport [GO:0006869]; mitochondrion organization [GO:0007005]; negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:1905090]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]; response to insulin [GO:0032868]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dense core granule membrane [GO:0032127]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial outer membrane [GO:0005741]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; dense core granule membrane [GO:0032127]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial outer membrane [GO:0005741]; Golgi to endosome transport [GO:0006895]; lipid transport [GO:0006869]; mitochondrion organization [GO:0007005]; negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:1905090]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]; response to insulin [GO:0032868]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:26942284}. Lipid droplet {ECO:0000269|PubMed:30093493}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30093493}. Lysosome membrane {ECO:0000269|PubMed:30093493}. Late endosome membrane {ECO:0000269|PubMed:30093493}. Note=May localize to endoplasmic reticulum-endolysosome contact sites. {ECO:0000269|PubMed:30093493}.
Q709F0	reviewed	ACD11_HUMAN	Acyl-CoA dehydrogenase family member 11 (ACAD-11) (EC 1.3.8.-)	ACAD11	Homo sapiens (Human)	780	FUNCTION: Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA (PubMed:21237683). Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain (Probable). {ECO:0000269|PubMed:21237683, ECO:0000305|PubMed:21237683}.		fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisome [GO:0005777]	acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; long-chain-acyl-CoA dehydrogenase activity [GO:0004466]; medium-chain-acyl-CoA dehydrogenase activity [GO:0070991]; very-long-chain-acyl-CoA dehydrogenase activity [GO:0017099]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisome [GO:0005777]; acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; long-chain-acyl-CoA dehydrogenase activity [GO:0004466]; medium-chain-acyl-CoA dehydrogenase activity [GO:0070991]; very-long-chain-acyl-CoA dehydrogenase activity [GO:0017099]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q80XL6}. Mitochondrion membrane {ECO:0000269|PubMed:21237683}. Note=Has been detected associated with mitochondrial membrane, but no matrix, in kidney and cerebellum, as well as in a neuroblastoma cell line, but not in skin fibroblasts, where it is observed in cytoplasmic vesicles (PubMed:21237683). No mitochondrial targeting signals could be predicted for any known isoform, including a putative isoform starting at Met-316. {ECO:0000269|PubMed:21237683}.
Q70CQ1	reviewed	UBP49_HUMAN	Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.4.19.12) (Deubiquitinating enzyme 49) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49)	USP49	Homo sapiens (Human)	688	FUNCTION: Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons. {ECO:0000269|PubMed:23824326}.		mRNA splicing, via spliceosome [GO:0000398]; protein deubiquitination [GO:0016579]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; histone H2B deubiquitinase activity [GO:0140936]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; histone H2B deubiquitinase activity [GO:0140936]; zinc ion binding [GO:0008270]; mRNA splicing, via spliceosome [GO:0000398]; protein deubiquitination [GO:0016579]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:23824326}.
Q70CQ2	reviewed	UBP34_HUMAN	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34)	USP34 KIAA0570 KIAA0729	Homo sapiens (Human)	3546	FUNCTION: Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}.		positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]	cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; Wnt signaling pathway [GO:0016055]	
Q70CQ3	reviewed	UBP30_HUMAN	Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30)	USP30	Homo sapiens (Human)	517	FUNCTION: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). {ECO:0000250|UniProtKB:Q3UN04, ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951}.		autophagy of mitochondrion [GO:0000422]; mitochondrial fusion [GO:0008053]; negative regulation of mitophagy [GO:1901525]; pexophagy [GO:0000425]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K6-linked deubiquitination [GO:0044313]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; autophagy of mitochondrion [GO:0000422]; mitochondrial fusion [GO:0008053]; negative regulation of mitophagy [GO:1901525]; pexophagy [GO:0000425]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K6-linked deubiquitination [GO:0044313]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179}.
Q70CQ4	reviewed	UBP31_HUMAN	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31)	USP31 KIAA1203	Homo sapiens (Human)	1352	FUNCTION: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}.		protein deubiquitination [GO:0016579]	nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; protein deubiquitination [GO:0016579]	
Q70E73	reviewed	RAPH1_HUMAN	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)	RAPH1 ALS2CR18 ALS2CR9 KIAA1681 LPD PREL2 RMO1	Homo sapiens (Human)	1250	FUNCTION: Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.		axon extension [GO:0048675]; signal transduction [GO:0007165]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]		cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; axon extension [GO:0048675]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15469845}; Peripheral membrane protein {ECO:0000269|PubMed:15469845}; Cytoplasmic side {ECO:0000269|PubMed:15469845}. Cell projection, lamellipodium {ECO:0000269|PubMed:15469845}. Cell projection, filopodium {ECO:0000269|PubMed:15469845}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15469845}. Note=Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin.
Q70EK8	reviewed	UBP53_HUMAN	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin-specific peptidase 53)	USP53 KIAA1350	Homo sapiens (Human)	1073	FUNCTION: Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions. Has no peptidase activity (PubMed:14715245). {ECO:0000269|PubMed:14715245, ECO:0000269|PubMed:32124521}.		action potential [GO:0001508]; epithelial cell apoptotic process [GO:1904019]; outer hair cell apoptotic process [GO:1905584]; response to auditory stimulus [GO:0010996]; sensory perception of sound [GO:0007605]	bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]		bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; action potential [GO:0001508]; epithelial cell apoptotic process [GO:1904019]; outer hair cell apoptotic process [GO:1905584]; response to auditory stimulus [GO:0010996]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:P15975}.
Q70EK9	reviewed	UBP51_HUMAN	Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.4.19.12) (Deubiquitinating enzyme 51) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51)	USP51	Homo sapiens (Human)	711	FUNCTION: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998). {ECO:0000269|PubMed:27083998}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; protein deubiquitination [GO:0016579]; regulation of cell cycle process [GO:0010564]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]	chromosome [GO:0005694]	chromatin binding [GO:0003682]; cysteine-type deubiquitinase activity [GO:0004843]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; chromatin binding [GO:0003682]; cysteine-type deubiquitinase activity [GO:0004843]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; zinc ion binding [GO:0008270]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; protein deubiquitination [GO:0016579]; regulation of cell cycle process [GO:0010564]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]	SUBCELLULAR LOCATION: Chromosome {ECO:0000305|PubMed:27083998}. Note=Upon DNA damage, chromatin-bound USP51 disassociates from chromatin immediately following DNA damage and reassociates with chromatin following DNA repair. {ECO:0000269|PubMed:27083998}.
Q70EL1	reviewed	UBP54_HUMAN	Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin-specific peptidase 54)	USP54 C10orf29	Homo sapiens (Human)	1684	FUNCTION: Has no peptidase activity.				cysteine-type deubiquitinase activity [GO:0004843]	cysteine-type deubiquitinase activity [GO:0004843]	
Q70EL2	reviewed	UBP45_HUMAN	Ubiquitin carboxyl-terminal hydrolase 45 (EC 3.4.19.12) (Deubiquitinating enzyme 45) (Ubiquitin thioesterase 45) (Ubiquitin-specific-processing protease 45)	USP45	Homo sapiens (Human)	814	FUNCTION: Catalyzes the deubiquitination of SPDL1 (PubMed:30258100). Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (PubMed:25538220). May be involved in the maintenance of photoreceptor function (PubMed:30573563). May play a role in normal retinal development (By similarity). Plays a role in cell migration (PubMed:30258100). {ECO:0000250|UniProtKB:E9QG68, ECO:0000269|PubMed:25538220, ECO:0000269|PubMed:30258100, ECO:0000269|PubMed:30573563}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell migration [GO:0016477]; DNA repair [GO:0006281]; global genome nucleotide-excision repair [GO:0070911]; neural retina development [GO:0003407]; photoreceptor cell maintenance [GO:0045494]; protein deubiquitination [GO:0016579]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]	cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270]; cell migration [GO:0016477]; DNA repair [GO:0006281]; global genome nucleotide-excision repair [GO:0070911]; neural retina development [GO:0003407]; photoreceptor cell maintenance [GO:0045494]; protein deubiquitination [GO:0016579]	SUBCELLULAR LOCATION: Photoreceptor inner segment {ECO:0000269|PubMed:30573563}. Cytoplasm {ECO:0000269|PubMed:25538220}. Nucleus {ECO:0000269|PubMed:25538220}.
Q70EL3	reviewed	UBP50_HUMAN	Inactive ubiquitin carboxyl-terminal hydrolase 50 (Inactive ubiquitin-specific peptidase 50)	USP50	Homo sapiens (Human)	339	FUNCTION: Has no peptidase activity.	MISCELLANEOUS: [Isoform 1]: Splicing events through non-canonical splice sites. {ECO:0000305}.	endosome organization [GO:0007032]; nuclear speck organization [GO:0035063]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein deubiquitination [GO:0016579]; Ras protein signal transduction [GO:0007265]	cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of plasma membrane [GO:0019897]; midbody [GO:0030496]; postsynaptic density [GO:0014069]	cysteine-type deubiquitinase activity [GO:0004843]; ubiquitin-like protein peptidase activity [GO:0019783]	cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of plasma membrane [GO:0019897]; midbody [GO:0030496]; postsynaptic density [GO:0014069]; cysteine-type deubiquitinase activity [GO:0004843]; ubiquitin-like protein peptidase activity [GO:0019783]; endosome organization [GO:0007032]; nuclear speck organization [GO:0035063]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein deubiquitination [GO:0016579]; Ras protein signal transduction [GO:0007265]	
Q70EL4	reviewed	UBP43_HUMAN	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43)	USP43	Homo sapiens (Human)	1123	FUNCTION: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}.		proteolysis [GO:0006508]; translesion synthesis [GO:0019985]	nucleoplasm [GO:0005654]	cysteine-type deubiquitinase activity [GO:0004843]; ISG15-specific peptidase activity [GO:0019785]	nucleoplasm [GO:0005654]; cysteine-type deubiquitinase activity [GO:0004843]; ISG15-specific peptidase activity [GO:0019785]; proteolysis [GO:0006508]; translesion synthesis [GO:0019985]	
Q70HW3	reviewed	SAMC_HUMAN	Mitochondrial S-adenosylmethionine carrier protein (SAM carrier) (Solute carrier family 25 member 26)	SLC25A26 SAMC	Homo sapiens (Human)	274	FUNCTION: Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl-L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions. {ECO:0000269|PubMed:14674884, ECO:0000269|PubMed:26522469, ECO:0000269|PubMed:35024855}.		macromolecule methylation [GO:0043414]; mitochondrial S-adenosyl-L-methionine transmembrane transport [GO:1990543]; monoatomic ion transport [GO:0006811]; S-adenosyl-L-methionine transport [GO:0015805]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	S-adenosyl-L-methionine transmembrane transporter activity [GO:0000095]; S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity [GO:0180003]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; S-adenosyl-L-methionine transmembrane transporter activity [GO:0000095]; S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity [GO:0180003]; macromolecule methylation [GO:0043414]; mitochondrial S-adenosyl-L-methionine transmembrane transport [GO:1990543]; monoatomic ion transport [GO:0006811]; S-adenosyl-L-methionine transport [GO:0015805]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:14674884, ECO:0000305|PubMed:26522469}; Multi-pass membrane protein {ECO:0000255}.
Q70IA6	reviewed	MOB2_HUMAN	MOB kinase activator 2 (HCCA2) (Mob2 homolog) (Mps one binder kinase activator-like 2)	MOB2 HCCA2	Homo sapiens (Human)	237	FUNCTION: Stimulates the autophosphorylation and kinase activity of STK38 and STK38L. {ECO:0000269|PubMed:15067004}.		positive regulation of protein phosphorylation [GO:0001934]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; positive regulation of protein phosphorylation [GO:0001934]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15067004}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15067004}.
Q70IA8	reviewed	MOB3C_HUMAN	MOB kinase activator 3C (Mob1 homolog 2C) (Mps one binder kinase activator-like 2C)	MOB3C MOBKL2C	Homo sapiens (Human)	216	FUNCTION: May regulate the activity of kinases. {ECO:0000250}.		positive regulation of protein phosphorylation [GO:0001934]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; positive regulation of protein phosphorylation [GO:0001934]; signal transduction [GO:0007165]	
Q70J99	reviewed	UN13D_HUMAN	Protein unc-13 homolog D (Munc13-4)	UNC13D	Homo sapiens (Human)	1090	FUNCTION: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:15548590, ECO:0000269|PubMed:17237785}.		defense response to virus [GO:0051607]; germinal center formation [GO:0002467]; granuloma formation [GO:0002432]; natural killer cell degranulation [GO:0043320]; phagocytosis [GO:0006909]; positive regulation of exocytosis [GO:0045921]; positive regulation of regulated secretory pathway [GO:1903307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of mast cell degranulation [GO:0043304]; secretion [GO:0046903]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; recycling endosome [GO:0055037]; Weibel-Palade body [GO:0033093]	metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; recycling endosome [GO:0055037]; Weibel-Palade body [GO:0033093]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; defense response to virus [GO:0051607]; germinal center formation [GO:0002467]; granuloma formation [GO:0002432]; natural killer cell degranulation [GO:0043320]; phagocytosis [GO:0006909]; positive regulation of exocytosis [GO:0045921]; positive regulation of regulated secretory pathway [GO:1903307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of mast cell degranulation [GO:0043304]; secretion [GO:0046903]	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Late endosome. Recycling endosome. Lysosome. Note=Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles.
Q70JA7	reviewed	CHSS3_HUMAN	Chondroitin sulfate synthase 3 (EC 2.4.1.175) (EC 2.4.1.226) (Carbohydrate synthase 2) (Chondroitin glucuronyltransferase 3) (Chondroitin synthase 2) (ChSy-2) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3) (N-acetylgalactosaminyltransferase 3)	CHSY3 CHSY2 CSS3	Homo sapiens (Human)	882	FUNCTION: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. {ECO:0000269|PubMed:12907687}.		chondroitin sulfate biosynthetic process [GO:0030206]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510]; chondroitin sulfate biosynthetic process [GO:0030206]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:12907687}; Single-pass type II membrane protein {ECO:0000305|PubMed:12907687}.
Q70SY1	reviewed	CR3L2_HUMAN	Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2]	CREB3L2 BBF2H7	Homo sapiens (Human)	520	FUNCTION: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52, ECO:0000269|PubMed:17178827}.		cartilage development [GO:0051216]; chondrocyte differentiation [GO:0002062]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]	chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cAMP response element binding [GO:0035497]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cAMP response element binding [GO:0035497]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; transcription cis-regulatory region binding [GO:0000976]; cartilage development [GO:0051216]; chondrocyte differentiation [GO:0002062]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BH52}; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. {ECO:0000250|UniProtKB:Q8BH52}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus. Note=Upon ER stress, translocated into the nucleus. {ECO:0000250|UniProtKB:Q8BH52}.
Q70UQ0	reviewed	IKIP_HUMAN	Inhibitor of nuclear factor kappa-B kinase-interacting protein (I kappa-B kinase-interacting protein) (IKBKB-interacting protein) (IKK-interacting protein)	IKBIP IKIP	Homo sapiens (Human)	350	FUNCTION: Target of p53/TP53 with pro-apoptotic function. {ECO:0000269|PubMed:15389287}.	MISCELLANEOUS: Shares a common promoter with APAF1 from which the 2 genes are transcribed in opposite directions.	response to X-ray [GO:0010165]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleolus [GO:0005730]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleolus [GO:0005730]; response to X-ray [GO:0010165]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15389287}; Single-pass membrane protein {ECO:0000269|PubMed:15389287}. Note=Isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization.
Q70YC4	reviewed	TALAN_HUMAN	Talanin	ZNF365 KIAA0844	Homo sapiens (Human)	216	FUNCTION: May play a role in uric acid excretion.	MISCELLANEOUS: Isoform 4 (talanin) of ZNF365 does not exist in rodents. In primates, a canonical intron-exon structure exist, with several stop codons preventing talanin production in old world and new world monkeys. It seems therefore that isoform 4 transcript emerged during primate evolution from a noncoding genomic sequence.	gamma-tubulin complex localization [GO:0033566]; mitotic cytokinesis [GO:0000281]	centrosome [GO:0005813]	protein homodimerization activity [GO:0042803]	centrosome [GO:0005813]; protein homodimerization activity [GO:0042803]; gamma-tubulin complex localization [GO:0033566]; mitotic cytokinesis [GO:0000281]	
Q70YC5	reviewed	ZN365_HUMAN	Protein ZNF365 (DISC1-binding zinc-finger protein) (Protein su48)	ZNF365 DBZ KIAA0844	Homo sapiens (Human)	407	FUNCTION: Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166). Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040). {ECO:0000250|UniProtKB:Q8BG89, ECO:0000269|PubMed:17389905, ECO:0000269|PubMed:23776040, ECO:0000269|PubMed:23966166}.	MISCELLANEOUS: Cells silencing ZNF365 display delayed mitotic progression and exit, due to increased replication stress, and ultimately leading to cytokinesis failure, re-duplication of centrosomes and increased aneuploidy. {ECO:0000269|PubMed:23966166}.	cerebellar molecular layer morphogenesis [GO:0021687]; dendrite arborization [GO:0140059]; dendritic spine morphogenesis [GO:0060997]; negative regulation of neuron projection development [GO:0010977]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA strand resection involved in replication fork processing [GO:0110026]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of neuron projection development [GO:0010975]; telomere maintenance [GO:0000723]	centrosome [GO:0005813]; cytoplasm [GO:0005737]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; cerebellar molecular layer morphogenesis [GO:0021687]; dendrite arborization [GO:0140059]; dendritic spine morphogenesis [GO:0060997]; negative regulation of neuron projection development [GO:0010977]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA strand resection involved in replication fork processing [GO:0110026]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of neuron projection development [GO:0010975]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16617106}. Note=localizes to the centrosome at all stages of the cell cycle. {ECO:0000269|PubMed:16617106}.
Q70Z35	reviewed	PREX2_HUMAN	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2)	PREX2 DEPDC2	Homo sapiens (Human)	1606	FUNCTION: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. {ECO:0000269|PubMed:15304342, ECO:0000269|PubMed:15304343, ECO:0000269|PubMed:15897194}.		adult locomotory behavior [GO:0008344]; dendrite morphogenesis [GO:0048813]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; regulation of signaling [GO:0023051]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; adult locomotory behavior [GO:0008344]; dendrite morphogenesis [GO:0048813]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; regulation of signaling [GO:0023051]; regulation of small GTPase mediated signal transduction [GO:0051056]	
Q70Z44	reviewed	5HT3D_HUMAN	5-hydroxytryptamine receptor 3D (5-HT3-D) (5-HT3D) (Serotonin receptor 3D)	HTR3D	Homo sapiens (Human)	454	FUNCTION: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. {ECO:0000269|PubMed:17392525}.		inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; serotonin-gated monoatomic cation-selective channel activity [GO:0022850]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; serotonin-gated monoatomic cation-selective channel activity [GO:0022850]; inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:17392525}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:17392525}; Multi-pass membrane protein {ECO:0000255}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. {ECO:0000269|PubMed:17392525}.
Q70Z53	reviewed	F10C1_HUMAN	Protein FRA10AC1	FRA10AC1 C10orf4 PRO2972	Homo sapiens (Human)	315	FUNCTION: May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:34694367}.		dephosphorylation [GO:0016311]; mRNA splicing, via spliceosome [GO:0000398]	nucleus [GO:0005634]	phosphatase activity [GO:0016791]	nucleus [GO:0005634]; phosphatase activity [GO:0016791]; dephosphorylation [GO:0016311]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15203205, ECO:0000269|PubMed:34694367}.
Q712K3	reviewed	UB2R2_HUMAN	Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2)	UBE2R2 CDC34B UBC3B	Homo sapiens (Human)	238	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin. {ECO:0000269|PubMed:12037680, ECO:0000269|PubMed:20061386}.		protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q719H9	reviewed	KCTD1_HUMAN	BTB/POZ domain-containing protein KCTD1 (Potassium channel tetramerization domain-containing protein 1)	KCTD1 C18orf5	Homo sapiens (Human)	257	FUNCTION: May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. {ECO:0000269|PubMed:18358072, ECO:0000269|PubMed:19115315}.		negative regulation of DNA-templated transcription [GO:0045892]; protein homooligomerization [GO:0051260]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; negative regulation of DNA-templated transcription [GO:0045892]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18358072}.
Q71DI3	reviewed	H32_HUMAN	Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o)	H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D	Homo sapiens (Human)	136	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		chromatin organization [GO:0006325]; nucleosome assembly [GO:0006334]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; chromatin organization [GO:0006325]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q71F23	reviewed	CENPU_HUMAN	Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1)	CENPU ICEN24 KLIP1 MLF1IP PBIP1	Homo sapiens (Human)	418	FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}.		chordate embryonic development [GO:0043009]; chromosome segregation [GO:0007059]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		centriolar satellite [GO:0034451]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chordate embryonic development [GO:0043009]; chromosome segregation [GO:0007059]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.
Q71F56	reviewed	MD13L_HUMAN	Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)	MED13L KIAA1025 PROSIT240 THRAP2 TRAP240L	Homo sapiens (Human)	2210	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.		regulation of transcription by RNA polymerase II [GO:0006357]	mediator complex [GO:0016592]	transcription coregulator activity [GO:0003712]	mediator complex [GO:0016592]; transcription coregulator activity [GO:0003712]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q71H61	reviewed	ILDR2_HUMAN	Immunoglobulin-like domain-containing receptor 2 (Angulin-3)	ILDR2 C1orf32	Homo sapiens (Human)	639	FUNCTION: May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion. With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (By similarity). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:B5TVM2, ECO:0000269|PubMed:29431694}.		cell differentiation [GO:0030154]; homeostasis of number of cells within a tissue [GO:0048873]; insulin secretion [GO:0030073]; negative regulation of T cell activation [GO:0050868]; pancreas development [GO:0031016]; regulation of RNA splicing [GO:0043484]; response to glucose [GO:0009749]	bicellular tight junction [GO:0005923]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; tight junction [GO:0070160]		bicellular tight junction [GO:0005923]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; tight junction [GO:0070160]; cell differentiation [GO:0030154]; homeostasis of number of cells within a tissue [GO:0048873]; insulin secretion [GO:0030073]; negative regulation of T cell activation [GO:0050868]; pancreas development [GO:0031016]; regulation of RNA splicing [GO:0043484]; response to glucose [GO:0009749]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:B5TVM2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:B5TVM2}. Cell junction, tight junction {ECO:0000250|UniProtKB:B5TVM2}. Nucleus {ECO:0000250|UniProtKB:B5TVM2}.
Q71RC2	reviewed	LARP4_HUMAN	La-related protein 4 (La ribonucleoprotein domain family member 4)	LARP4 PP13296	Homo sapiens (Human)	724	FUNCTION: RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}.	MISCELLANEOUS: [Isoform 3]: May be due to competing acceptor splice site. {ECO:0000305}.	cytoskeleton organization [GO:0007010]; positive regulation of translation [GO:0045727]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell morphogenesis [GO:0022604]; translation [GO:0006412]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]	mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; cytoskeleton organization [GO:0007010]; positive regulation of translation [GO:0045727]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell morphogenesis [GO:0022604]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, Stress granule {ECO:0000269|PubMed:21098120}. Cytoplasm, cytosol {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:27615744}. Note=Localized throughout the cytosol. Partially localized in stress granules in response to arsenite treatment. {ECO:0000269|PubMed:21098120}.
Q71RG4	reviewed	TMUB2_HUMAN	Transmembrane and ubiquitin-like domain-containing protein 2	TMUB2 FP2653 UNQ1897/PRO4343	Homo sapiens (Human)	321			ubiquitin-dependent ERAD pathway [GO:0030433]	membrane [GO:0016020]		membrane [GO:0016020]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q71RS6	reviewed	NCKX5_HUMAN	Sodium/potassium/calcium exchanger 5 (Na(+)/K(+)/Ca(2+)-exchange protein 5) (Solute carrier family 24 member 5)	SLC24A5 JSX NCKX5	Homo sapiens (Human)	500	FUNCTION: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+) (PubMed:18166528). Involved in pigmentation, possibly by participating in ion transport in melanosomes (PubMed:16357253, PubMed:18166528). Predominant sodium-calcium exchanger in melanocytes (PubMed:16357253, PubMed:18166528). {ECO:0000269|PubMed:16357253, ECO:0000269|PubMed:18166528}.		calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; negative regulation of melanin biosynthetic process [GO:0048022]; response to stimulus [GO:0050896]	melanosome [GO:0042470]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]	melanosome [GO:0042470]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]; calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; negative regulation of melanin biosynthetic process [GO:0048022]; response to stimulus [GO:0050896]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18166528}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in late-stage melanosomes. {ECO:0000269|PubMed:17081065}.
Q71SY5	reviewed	MED25_HUMAN	Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78)	MED25 ACID1 ARC92 PTOV2 TCBAP0758	Homo sapiens (Human)	747	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. {ECO:0000269|PubMed:14657022, ECO:0000269|PubMed:14983011, ECO:0000269|PubMed:17641689}.		negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chromatin binding [GO:0035563]; positive regulation of mediator complex assembly [GO:2001178]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; transcription coactivator binding [GO:0001223]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; transcription coactivator binding [GO:0001223]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chromatin binding [GO:0035563]; positive regulation of mediator complex assembly [GO:2001178]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14657022}.
Q71U36	reviewed	TBA1A_HUMAN	Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]	TUBA1A TUBA3	Homo sapiens (Human)	451	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; cellular response to calcium ion [GO:0071277]; centrosome cycle [GO:0007098]; cerebellar cortex morphogenesis [GO:0021696]; cerebral cortex development [GO:0021987]; cytoskeleton-dependent intracellular transport [GO:0030705]; dentate gyrus development [GO:0021542]; forebrain morphogenesis [GO:0048853]; gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular protein transport [GO:0006886]; memory [GO:0007613]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; motor behavior [GO:0061744]; neuron apoptotic process [GO:0051402]; neuron migration [GO:0001764]; neuron projection arborization [GO:0140058]; organelle transport along microtubule [GO:0072384]; regulation of synapse organization [GO:0050807]; response to L-glutamate [GO:1902065]; response to mechanical stimulus [GO:0009612]; response to tumor necrosis factor [GO:0034612]; smoothened signaling pathway [GO:0007224]; startle response [GO:0001964]; synapse organization [GO:0050808]; visual learning [GO:0008542]	axonemal microtubule [GO:0005879]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]	axonemal microtubule [GO:0005879]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; cellular response to calcium ion [GO:0071277]; centrosome cycle [GO:0007098]; cerebellar cortex morphogenesis [GO:0021696]; cerebral cortex development [GO:0021987]; cytoskeleton-dependent intracellular transport [GO:0030705]; dentate gyrus development [GO:0021542]; forebrain morphogenesis [GO:0048853]; gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular protein transport [GO:0006886]; memory [GO:0007613]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; motor behavior [GO:0061744]; neuron apoptotic process [GO:0051402]; neuron migration [GO:0001764]; neuron projection arborization [GO:0140058]; organelle transport along microtubule [GO:0072384]; regulation of synapse organization [GO:0050807]; response to L-glutamate [GO:1902065]; response to mechanical stimulus [GO:0009612]; response to tumor necrosis factor [GO:0034612]; smoothened signaling pathway [GO:0007224]; startle response [GO:0001964]; synapse organization [GO:0050808]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
Q71UI9	reviewed	H2AV_HUMAN	Histone H2A.V (H2A.F/Z) (H2A.Z variant histone 2)	H2AZ2 H2AFV H2AV	Homo sapiens (Human)	128	FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). {ECO:0000250}.		chromatin organization [GO:0006325]	extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; chromatin organization [GO:0006325]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Q71UM5	reviewed	RS27L_HUMAN	Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like)	RPS27L	Homo sapiens (Human)	84			activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; positive regulation of translation [GO:0045727]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]	cytosolic small ribosomal subunit [GO:0022627]; nucleus [GO:0005634]	cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation activator activity [GO:0008494]	cytosolic small ribosomal subunit [GO:0022627]; nucleus [GO:0005634]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation activator activity [GO:0008494]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; positive regulation of translation [GO:0045727]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]	
Q75N03	reviewed	HAKAI_HUMAN	E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai)	CBLL1 HAKAI RNF188	Homo sapiens (Human)	491	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). {ECO:0000250|UniProtKB:Q9JIY2, ECO:0000269|PubMed:29507755}.		cell-cell adhesion [GO:0098609]; mRNA methylation [GO:0080009]; negative regulation of cell adhesion [GO:0007162]; positive regulation of cell migration [GO:0030335]; positive regulation of endocytosis [GO:0045807]; protein ubiquitination [GO:0016567]; regulation of cell adhesion [GO:0030155]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; ubiquitin ligase complex [GO:0000151]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; ubiquitin ligase complex [GO:0000151]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cell-cell adhesion [GO:0098609]; mRNA methylation [GO:0080009]; negative regulation of cell adhesion [GO:0007162]; positive regulation of cell migration [GO:0030335]; positive regulation of endocytosis [GO:0045807]; protein ubiquitination [GO:0016567]; regulation of cell adhesion [GO:0030155]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:24100041}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24100041}. Cytoplasm {ECO:0000250|UniProtKB:Q9JIY2}. Note=Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus. {ECO:0000250|UniProtKB:Q9JIY2}.
Q75N90	reviewed	FBN3_HUMAN	Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide]	FBN3 KIAA1776	Homo sapiens (Human)	2809	FUNCTION: [Fibrillin-3]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support. {ECO:0000269|PubMed:14962672}.		anatomical structure morphogenesis [GO:0009653]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; anatomical structure morphogenesis [GO:0009653]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:14962672}.
Q75QN2	reviewed	INT8_HUMAN	Integrator complex subunit 8 (Int8) (Protein kaonashi-1)	INTS8 C8orf52	Homo sapiens (Human)	995	FUNCTION: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. {ECO:0000269|PubMed:28542170}.		regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q75T13	reviewed	PGAP1_HUMAN	GPI inositol-deacylase (EC 3.1.-.-) (Post-GPI attachment to proteins factor 1) (hPGAP1)	PGAP1 UNQ3024/PRO9822	Homo sapiens (Human)	922	FUNCTION: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	anterior/posterior axis specification [GO:0009948]; attachment of GPI anchor to protein [GO:0016255]; embryonic pattern specification [GO:0009880]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; forebrain regionalization [GO:0021871]; GPI anchor metabolic process [GO:0006505]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; protein transport [GO:0015031]; sensory perception of sound [GO:0007605]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	hydrolase activity, acting on ester bonds [GO:0016788]; phosphatidylinositol deacylase activity [GO:0050185]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; hydrolase activity, acting on ester bonds [GO:0016788]; phosphatidylinositol deacylase activity [GO:0050185]; anterior/posterior axis specification [GO:0009948]; attachment of GPI anchor to protein [GO:0016255]; embryonic pattern specification [GO:0009880]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; forebrain regionalization [GO:0021871]; GPI anchor metabolic process [GO:0006505]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; protein transport [GO:0015031]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q75V66	reviewed	ANO5_HUMAN	Anoctamin-5 (Gnathodiaphyseal dysplasia 1 protein) (Transmembrane protein 16E)	ANO5 GDD1 TMEM16E	Homo sapiens (Human)	913	FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC) activity. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:23047743}.	MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.	chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15124103}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with CALR/calreticulin (PubMed:15124103). Shows an intracellular localization according to PubMed:22075693. {ECO:0000269|PubMed:15124103, ECO:0000269|PubMed:22075693}.
Q75WM6	reviewed	H1FNT_HUMAN	Testis-specific H1 histone (Haploid germ cell-specific nuclear protein 1) (Histone H1.7) (Histone H1t2)	H1-7 H1FNT HANP1	Homo sapiens (Human)	255	FUNCTION: Essential for normal spermatogenesis and male fertility (PubMed:16533358). Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. {ECO:0000250|UniProtKB:Q8CJI4, ECO:0000269|PubMed:16533358}.		chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; sperm DNA condensation [GO:0035092]; spermatid nucleus elongation [GO:0007290]	chromatin [GO:0000785]; nucleus [GO:0005634]	ATP binding [GO:0005524]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]	chromatin [GO:0000785]; nucleus [GO:0005634]; ATP binding [GO:0005524]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; sperm DNA condensation [GO:0035092]; spermatid nucleus elongation [GO:0007290]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8CJI4}. Chromosome {ECO:0000250|UniProtKB:Q8CJI4}. Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole. {ECO:0000250|UniProtKB:Q8CJI4}.
Q765P7	reviewed	MTSS2_HUMAN	Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein)	MTSS2 MTSS1L	Homo sapiens (Human)	747	FUNCTION: Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}.		activation of GTPase activity [GO:0090630]; cell projection assembly [GO:0030031]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; lamellipodium organization [GO:0097581]; membrane organization [GO:0061024]; plasma membrane organization [GO:0007009]	actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; lamellipodium [GO:0030027]; ruffle membrane [GO:0032587]	actin binding [GO:0003779]; actin monomer binding [GO:0003785]; GTPase activator activity [GO:0005096]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; lamellipodium [GO:0030027]; ruffle membrane [GO:0032587]; actin binding [GO:0003779]; actin monomer binding [GO:0003785]; GTPase activator activity [GO:0005096]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]; activation of GTPase activity [GO:0090630]; cell projection assembly [GO:0030031]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; lamellipodium organization [GO:0097581]; membrane organization [GO:0061024]; plasma membrane organization [GO:0007009]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20875796}. Cell projection, ruffle {ECO:0000269|PubMed:20875796}. Note=Colocalizes with RAC1 within membrane ruffles. {ECO:0000269|PubMed:20875796}.
Q76EJ3	reviewed	S35D2_HUMAN	Nucleotide sugar transporter SLC35D2 (Homolog of Fringe connection protein 1) (HFRC1) (SQV7-like protein) (SQV7L) (Solute carrier family 35 member D2) (UDP-galactose transporter-related protein 8) (UGTrel8)	SLC35D2 HFRC UGTREL8	Homo sapiens (Human)	337	FUNCTION: Nucleotide sugar antiporter transporting UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-glucose (UDP-Glc) from the cytosol into the lumen of the Golgi in exchange of UMP. By supplying UDP-N-acetylglucosamine, a donor substrate to heparan sulfate synthases, probably takes part in the synthesis of these glycoconjugates. {ECO:0000305|PubMed:15082721, ECO:0000305|PubMed:15607426}.		carbohydrate transport [GO:0008643]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; keratan sulfate biosynthetic process [GO:0018146]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	antiporter activity [GO:0015297]; GDP-fucose transmembrane transporter activity [GO:0005457]; nucleotide-sugar transmembrane transporter activity [GO:0005338]; UDP-glucuronic acid transmembrane transporter activity [GO:0005461]; UDP-N-acetylgalactosamine transmembrane transporter activity [GO:0005463]; UDP-N-acetylglucosamine transmembrane transporter activity [GO:0005462]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; antiporter activity [GO:0015297]; GDP-fucose transmembrane transporter activity [GO:0005457]; nucleotide-sugar transmembrane transporter activity [GO:0005338]; UDP-glucuronic acid transmembrane transporter activity [GO:0005461]; UDP-N-acetylgalactosamine transmembrane transporter activity [GO:0005463]; UDP-N-acetylglucosamine transmembrane transporter activity [GO:0005462]; carbohydrate transport [GO:0008643]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; keratan sulfate biosynthetic process [GO:0018146]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15082721, ECO:0000269|PubMed:15607426}; Multi-pass membrane protein {ECO:0000255}.
Q76FK4	reviewed	NOL8_HUMAN	Nucleolar protein 8 (Nucleolar protein Nop132)	NOL8 C9orf34 NOP132	Homo sapiens (Human)	1167	FUNCTION: Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}.		protein localization to nucleolus [GO:1902570]; rRNA processing [GO:0006364]	chromosome [GO:0005694]; nucleolus [GO:0005730]	RNA binding [GO:0003723]	chromosome [GO:0005694]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; protein localization to nucleolus [GO:1902570]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis.
Q76I76	reviewed	SSH2_HUMAN	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L)	SSH2 KIAA1725 SSH2L	Homo sapiens (Human)	1423	FUNCTION: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}.	MISCELLANEOUS: Tyrosine phosphatase activity has not been demonstrated for this protein to date.	actin cytoskeleton organization [GO:0030036]; cell differentiation [GO:0030154]; negative regulation of actin filament polymerization [GO:0030837]; protein dephosphorylation [GO:0006470]; spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]	actin binding [GO:0003779]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; actin binding [GO:0003779]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; actin cytoskeleton organization [GO:0030036]; cell differentiation [GO:0030154]; negative regulation of actin filament polymerization [GO:0030837]; protein dephosphorylation [GO:0006470]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5SW75}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5SW75}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q5SW75}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q5SW75}. Note=Colocalizes with filamentous actin in the cytoplasm and the cell periphery. {ECO:0000250|UniProtKB:Q5SW75}.
Q76L83	reviewed	ASXL2_HUMAN	Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2)	ASXL2 ASXH2 KIAA1685	Homo sapiens (Human)	1435	FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. {ECO:0000250, ECO:0000269|PubMed:21047783}.		animal organ morphogenesis [GO:0009887]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleoplasm [GO:0005654]; PR-DUB complex [GO:0035517]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; peroxisome proliferator activated receptor binding [GO:0042975]	nucleoplasm [GO:0005654]; PR-DUB complex [GO:0035517]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; peroxisome proliferator activated receptor binding [GO:0042975]; animal organ morphogenesis [GO:0009887]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q76LX8	reviewed	ATS13_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS 13) (ADAM-TS13) (ADAMTS-13) (EC 3.4.24.87) (von Willebrand factor-cleaving protease) (vWF-CP) (vWF-cleaving protease)	ADAMTS13 C9orf8 UNQ6102/PRO20085	Homo sapiens (Human)	1427	FUNCTION: Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. {ECO:0000269|PubMed:19880749}.		cell-matrix adhesion [GO:0007160]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; extracellular matrix organization [GO:0030198]; glycoprotein metabolic process [GO:0009100]; integrin-mediated signaling pathway [GO:0007229]; peptide catabolic process [GO:0043171]; platelet activation [GO:0030168]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to amine [GO:0014075]; response to potassium ion [GO:0035864]; response to toxic substance [GO:0009636]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; cell-matrix adhesion [GO:0007160]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; extracellular matrix organization [GO:0030198]; glycoprotein metabolic process [GO:0009100]; integrin-mediated signaling pathway [GO:0007229]; peptide catabolic process [GO:0043171]; platelet activation [GO:0030168]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to amine [GO:0014075]; response to potassium ion [GO:0035864]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12791682}. Note=Secretion enhanced by O-fucosylation of TSP type-1 repeats.
Q76M96	reviewed	CCD80_HUMAN	Coiled-coil domain-containing protein 80 (Down-regulated by oncogenes protein 1) (Up-regulated in BRS-3 deficient mouse homolog)	CCDC80 DRO1 URB HBE245	Homo sapiens (Human)	950	FUNCTION: Promotes cell adhesion and matrix assembly. {ECO:0000250}.		extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]; response to bacterium [GO:0009617]	basement membrane [GO:0005604]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614]	fibronectin binding [GO:0001968]; heparin binding [GO:0008201]	basement membrane [GO:0005604]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q76MJ5	reviewed	ERN2_HUMAN	Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]	ERN2 IRE2	Homo sapiens (Human)	926	FUNCTION: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. {ECO:0000269|PubMed:11175748}.		apoptotic chromosome condensation [GO:0030263]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; protein phosphorylation [GO:0006468]; response to endoplasmic reticulum stress [GO:0034976]; rRNA catabolic process [GO:0016075]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum quality control compartment [GO:0044322]; IRE1-TRAF2-ASK1 complex [GO:1990604]	ATP binding [GO:0005524]; endonuclease activity [GO:0004519]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA endonuclease activity [GO:0004521]; unfolded protein binding [GO:0051082]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum quality control compartment [GO:0044322]; IRE1-TRAF2-ASK1 complex [GO:1990604]; ATP binding [GO:0005524]; endonuclease activity [GO:0004519]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA endonuclease activity [GO:0004521]; unfolded protein binding [GO:0051082]; apoptotic chromosome condensation [GO:0030263]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; protein phosphorylation [GO:0006468]; response to endoplasmic reticulum stress [GO:0034976]; rRNA catabolic process [GO:0016075]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11175748}; Single-pass type I membrane protein {ECO:0000269|PubMed:11175748}.
Q76N32	reviewed	CEP68_HUMAN	Centrosomal protein of 68 kDa (Cep68)	CEP68 KIAA0582	Homo sapiens (Human)	757	FUNCTION: Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}.		centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098]; protein localization to organelle [GO:0033365]	cell junction [GO:0030054]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]	cell junction [GO:0030054]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098]; protein localization to organelle [GO:0033365]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:31974111}. Note=Localizes to thin fibers protruding away from the proximal ends of the two centrioles. Dissociates from interphase centrosomes at the onset of mitosis. {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143}.
Q76N89	reviewed	HECW1_HUMAN	E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)	HECW1 KIAA0322 NEDL1	Homo sapiens (Human)	1606	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14684739}.
Q76NI1	reviewed	KNDC1_HUMAN	Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Cerebral protein 9) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2)	KNDC1 C10orf23 KIAA1768 RASGEF2 VKIND hucep-9	Homo sapiens (Human)	1749	FUNCTION: RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). {ECO:0000250|UniProtKB:Q0KK55, ECO:0000269|PubMed:24788352}.		cerebellar granule cell differentiation [GO:0021707]; positive regulation of protein phosphorylation [GO:0001934]; regulation of dendrite development [GO:0050773]; regulation of dendrite morphogenesis [GO:0048814]; small GTPase mediated signal transduction [GO:0007264]	dendrite [GO:0030425]; guanyl-nucleotide exchange factor complex [GO:0032045]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]	guanyl-nucleotide exchange factor activity [GO:0005085]	dendrite [GO:0030425]; guanyl-nucleotide exchange factor complex [GO:0032045]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; guanyl-nucleotide exchange factor activity [GO:0005085]; cerebellar granule cell differentiation [GO:0021707]; positive regulation of protein phosphorylation [GO:0001934]; regulation of dendrite development [GO:0050773]; regulation of dendrite morphogenesis [GO:0048814]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000250|UniProtKB:Q0KK55}. Perikaryon {ECO:0000250|UniProtKB:Q0KK55}.
Q7KYR7	reviewed	BT2A1_HUMAN	Butyrophilin subfamily 2 member A1	BTN2A1 BT2.1 BTF1	Homo sapiens (Human)	527			lipid metabolic process [GO:0006629]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; signaling receptor binding [GO:0005102]; lipid metabolic process [GO:0006629]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q7KZ85	reviewed	SPT6H_HUMAN	Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)	SUPT6H KIAA0162 SPT6H	Homo sapiens (Human)	1726	FUNCTION: Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}.		blastocyst formation [GO:0001825]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; nucleosome organization [GO:0034728]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of isotype switching [GO:0045191]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; regulation of muscle cell differentiation [GO:0051147]; RNA splicing [GO:0008380]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673]	nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]	DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]; DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; blastocyst formation [GO:0001825]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; nucleosome organization [GO:0034728]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of isotype switching [GO:0045191]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; regulation of muscle cell differentiation [GO:0051147]; RNA splicing [GO:0008380]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q7KZF4	reviewed	SND1_HUMAN	Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator)	SND1 TDRD11	Homo sapiens (Human)	910	FUNCTION: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:28546213, PubMed:18453631). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.		miRNA catabolic process [GO:0010587]; mRNA catabolic process [GO:0006402]; osteoblast differentiation [GO:0001649]; regulation of cell cycle process [GO:0010564]; regulatory ncRNA-mediated gene silencing [GO:0031047]	cytosol [GO:0005829]; dense body [GO:0097433]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; RISC complex [GO:0016442]	cadherin binding [GO:0045296]; endonuclease activity [GO:0004519]; endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [GO:0016894]; nuclease activity [GO:0004518]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; transcription coregulator activity [GO:0003712]	cytosol [GO:0005829]; dense body [GO:0097433]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; RISC complex [GO:0016442]; cadherin binding [GO:0045296]; endonuclease activity [GO:0004519]; endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [GO:0016894]; nuclease activity [GO:0004518]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; transcription coregulator activity [GO:0003712]; miRNA catabolic process [GO:0010587]; mRNA catabolic process [GO:0006402]; osteoblast differentiation [GO:0001649]; regulation of cell cycle process [GO:0010564]; regulatory ncRNA-mediated gene silencing [GO:0031047]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14508492, ECO:0000269|PubMed:17081065}. Nucleus {ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:14508492, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:7651391}. Melanosome {ECO:0000269|PubMed:17081065}. Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus (PubMed:12234934). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:17081065}.
Q7KZI7	reviewed	MARK2_HUMAN	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)	MARK2 EMK1	Homo sapiens (Human)	788	FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing of isoform 6. {ECO:0000269|PubMed:9730619}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 6. {ECO:0000269|PubMed:9730619}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 1. {ECO:0000269|PubMed:11433294}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Produced by alternative splicing of isoform 6. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 10]: Produced by alternative splicing of isoform 6. {ECO:0000305}.; MISCELLANEOUS: [Isoform 11]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 12]: Produced by alternative splicing of isoform 6. {ECO:0000305}.; MISCELLANEOUS: [Isoform 13]: Produced by alternative splicing of isoform 6. {ECO:0000305}.; MISCELLANEOUS: [Isoform 14]: Produced by alternative splicing of isoform 6. {ECO:0000305}.; MISCELLANEOUS: [Isoform 15]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 16]: Produced by alternative splicing of isoform 1. {ECO:0000305}.	activation of protein kinase activity [GO:0032147]; autophagy of mitochondrion [GO:0000422]; axon development [GO:0061564]; establishment of cell polarity [GO:0030010]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion localization [GO:0051646]; neuron migration [GO:0001764]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of neuron projection development [GO:0010976]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule binding [GO:1904526]; regulation of microtubule cytoskeleton organization [GO:0070507]; Wnt signaling pathway [GO:0016055]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microtubule bundle [GO:0097427]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; lipid binding [GO:0008289]; magnesium ion binding [GO:0000287]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microtubule bundle [GO:0097427]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; lipid binding [GO:0008289]; magnesium ion binding [GO:0000287]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; activation of protein kinase activity [GO:0032147]; autophagy of mitochondrion [GO:0000422]; axon development [GO:0061564]; establishment of cell polarity [GO:0030010]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion localization [GO:0051646]; neuron migration [GO:0001764]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of neuron projection development [GO:0010976]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule binding [GO:1904526]; regulation of microtubule cytoskeleton organization [GO:0070507]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cytoplasm. Lateral cell membrane. Cytoplasm, cytoskeleton. Cell projection, dendrite {ECO:0000269|PubMed:23666762}. Cytoplasm {ECO:0000269|PubMed:23666762}. Note=Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm.
Q7KZN9	reviewed	COX15_HUMAN	Cytochrome c oxidase assembly protein COX15 homolog	COX15	Homo sapiens (Human)	410	FUNCTION: May be involved in the biosynthesis of heme A. {ECO:0000269|PubMed:12474143}.		cellular respiration [GO:0045333]; heme A biosynthetic process [GO:0006784]; heme biosynthetic process [GO:0006783]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; proton transmembrane transport [GO:1902600]; respiratory chain complex IV assembly [GO:0008535]; respiratory gaseous exchange by respiratory system [GO:0007585]	cytochrome complex [GO:0070069]; mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	cytochrome-c oxidase activity [GO:0004129]; heme binding [GO:0020037]; molecular adaptor activity [GO:0060090]; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [GO:0016653]; oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627]	cytochrome complex [GO:0070069]; mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; cytochrome-c oxidase activity [GO:0004129]; heme binding [GO:0020037]; molecular adaptor activity [GO:0060090]; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [GO:0016653]; oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627]; cellular respiration [GO:0045333]; heme A biosynthetic process [GO:0006784]; heme biosynthetic process [GO:0006783]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; proton transmembrane transport [GO:1902600]; respiratory chain complex IV assembly [GO:0008535]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:9878253}; Multi-pass membrane protein {ECO:0000269|PubMed:9878253}.
Q7L014	reviewed	DDX46_HUMAN	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog)	DDX46 KIAA0801	Homo sapiens (Human)	1031	FUNCTION: Plays an essential role in splicing, either prior to, or during splicing A complex formation. {ECO:0000269|PubMed:12234937}.		mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	Cajal body [GO:0015030]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	Cajal body [GO:0015030]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:12234937}. Nucleus, Cajal body {ECO:0000269|PubMed:12234937}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Present in Cajal bodies (CBs) and nuclear speckles.
Q7L099	reviewed	RUFY3_HUMAN	Protein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar)	RUFY3 KIAA0871	Homo sapiens (Human)	469	FUNCTION: Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed:25766321). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:25766321}.		actin filament organization [GO:0007015]; cell differentiation [GO:0030154]; negative regulation of axonogenesis [GO:0050771]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular protein transport [GO:0090316]; regulation of axonogenesis [GO:0050770]; regulation of establishment of cell polarity [GO:2000114]	anchoring junction [GO:0070161]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]		anchoring junction [GO:0070161]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; actin filament organization [GO:0007015]; cell differentiation [GO:0030154]; negative regulation of axonogenesis [GO:0050771]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular protein transport [GO:0090316]; regulation of axonogenesis [GO:0050770]; regulation of establishment of cell polarity [GO:2000114]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25766321}. Endomembrane system {ECO:0000269|PubMed:20376209}. Cell projection, invadopodium {ECO:0000269|PubMed:25766321}. Perikaryon {ECO:0000250|UniProtKB:Q9D394}. Cell projection {ECO:0000250|UniProtKB:Q9D394}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9D394}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9D394}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9D394}. Note=Colocalizes with PAK1, F-actin, myosins and integrins in invadopodia at the cell periphery (PubMed:25766321). Colocalized with Ras-related Rab-5 proteins in cytoplasmic vesicles (PubMed:20376209). Accumulates in axon growth cones in a F-actin-dependent manner (By similarity). Colocalized with FSCN1 and F-actin at filipodia and lamellipodia of axonal growth cones (By similarity). Colocalized with DBN1 and F-actin at transitional domain of the axonal growth cone (By similarity). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:20376209, ECO:0000269|PubMed:25766321}.
Q7L0J3	reviewed	SV2A_HUMAN	Synaptic vesicle glycoprotein 2A	SV2A KIAA0736 PSEC0174	Homo sapiens (Human)	742	FUNCTION: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO:0000250}.; FUNCTION: (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. {ECO:0000269|PubMed:29649119, ECO:0000305|PubMed:29649119}.	MISCELLANEOUS: Identified as the brain binding-site for the antiepileptic drug levetiracetam/lev.	intracellular calcium ion homeostasis [GO:0006874]; regulation of gamma-aminobutyric acid secretion [GO:0014052]; synaptic vesicle priming [GO:0016082]	cell-cell junction [GO:0005911]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	protein kinase binding [GO:0019901]; transmembrane transporter activity [GO:0022857]	cell-cell junction [GO:0005911]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; protein kinase binding [GO:0019901]; transmembrane transporter activity [GO:0022857]; intracellular calcium ion homeostasis [GO:0006874]; regulation of gamma-aminobutyric acid secretion [GO:0014052]; synaptic vesicle priming [GO:0016082]	SUBCELLULAR LOCATION: Presynapse {ECO:0000250|UniProtKB:Q9JIS5}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q02563}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q02563}. Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. {ECO:0000250|UniProtKB:Q02563, ECO:0000250|UniProtKB:Q9JIS5}.
Q7L0Q8	reviewed	RHOU_HUMAN	Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)	RHOU ARHU CDC42L1 G28K WRCH1 SB128	Homo sapiens (Human)	258	FUNCTION: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:11459829, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:21834987}.		actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of protein targeting to mitochondrion [GO:1903955]; Rac protein signal transduction [GO:0016601]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]	cell projection [GO:0042995]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; podosome [GO:0002102]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]	cell projection [GO:0042995]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; podosome [GO:0002102]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of protein targeting to mitochondrion [GO:1903955]; Rac protein signal transduction [GO:0016601]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}; Lipid-anchor {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}; Cytoplasmic side {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Golgi apparatus membrane {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}; Lipid-anchor {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Cell junction, focal adhesion {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Cell projection, podosome {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Note=Localizes to podosomes in SRC-transformed cells. {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}.
Q7L0X0	reviewed	TRIL_HUMAN	TLR4 interactor with leucine rich repeats (Leucine-rich repeat-containing protein KIAA0644)	TRIL KIAA0644	Homo sapiens (Human)	811	FUNCTION: Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion. {ECO:0000269|PubMed:19710467}.		inflammatory response [GO:0006954]; innate immune response [GO:0045087]; regulation of cytokine production involved in immune response [GO:0002718]; toll-like receptor 4 signaling pathway [GO:0034142]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; lipopolysaccharide receptor complex [GO:0046696]	lipopolysaccharide binding [GO:0001530]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; lipopolysaccharide receptor complex [GO:0046696]; lipopolysaccharide binding [GO:0001530]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; regulation of cytokine production involved in immune response [GO:0002718]; toll-like receptor 4 signaling pathway [GO:0034142]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q7L0Y3	reviewed	TM10C_HUMAN	tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221)	TRMT10C MRPP1 RG9MTD1	Homo sapiens (Human)	403	FUNCTION: Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:27132592, ECO:0000269|PubMed:29040705, ECO:0000269|PubMed:29072297}.		mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA 5'-end processing [GO:0097745]; mitochondrial tRNA methylation [GO:0070901]; mitochondrial tRNA processing [GO:0090646]; mRNA methylation [GO:0080009]; positive regulation of mitochondrial translation [GO:0070131]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA methyltransferase complex [GO:0043527]	identical protein binding [GO:0042802]; mRNA (adenine-N1-)-methyltransferase activity [GO:0061953]; RNA binding [GO:0003723]; tRNA (adenine-N1-)-methyltransferase activity [GO:0016429]; tRNA (guanine(9)-N(1))-methyltransferase activity [GO:0052905]; tRNA (guanine-N1-)-methyltransferase activity [GO:0009019]; tRNA binding [GO:0000049]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA methyltransferase complex [GO:0043527]; identical protein binding [GO:0042802]; mRNA (adenine-N1-)-methyltransferase activity [GO:0061953]; RNA binding [GO:0003723]; tRNA (adenine-N1-)-methyltransferase activity [GO:0016429]; tRNA (guanine(9)-N(1))-methyltransferase activity [GO:0052905]; tRNA (guanine-N1-)-methyltransferase activity [GO:0009019]; tRNA binding [GO:0000049]; mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA 5'-end processing [GO:0097745]; mitochondrial tRNA methylation [GO:0070901]; mitochondrial tRNA processing [GO:0090646]; mRNA methylation [GO:0080009]; positive regulation of mitochondrial translation [GO:0070131]	SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:23473034, ECO:0000269|PubMed:24703694}.
Q7L190	reviewed	DPPA4_HUMAN	Developmental pluripotency-associated protein 4	DPPA4	Homo sapiens (Human)	304	FUNCTION: May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage. {ECO:0000250|UniProtKB:Q8CCG4}.		lung-associated mesenchyme development [GO:0060484]; system development [GO:0048731]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; lung-associated mesenchyme development [GO:0060484]; system development [GO:0048731]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8CCG4}. Note=Associated with transcriptionally active chromatin. {ECO:0000250|UniProtKB:Q8CCG4}.
Q7L1I2	reviewed	SV2B_HUMAN	Synaptic vesicle glycoprotein 2B	SV2B KIAA0735	Homo sapiens (Human)	683	FUNCTION: Probably plays a role in the control of regulated secretion in neural and endocrine cells. {ECO:0000250}.; FUNCTION: (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. {ECO:0000269|PubMed:29649119, ECO:0000305|PubMed:29649119}.		chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle exocytosis [GO:2000300]	acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	transmembrane transporter activity [GO:0022857]	acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter activity [GO:0022857]; chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle exocytosis [GO:2000300]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q63564}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q63564}. Note=Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas (By similarity). Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity). {ECO:0000250|UniProtKB:Q63564}.
Q7L1Q6	reviewed	5MP2_HUMAN	eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf)	BZW1 5MP2 BZAP45 KIAA0005	Homo sapiens (Human)	419	FUNCTION: Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:29470543, PubMed:34260931). Enhances histone H4 gene transcription but does not seem to bind DNA directly (PubMed:11524015). {ECO:0000269|PubMed:11524015, ECO:0000269|PubMed:29470543, ECO:0000269|PubMed:34260931}.		regulation of translational initiation [GO:0006446]	cytoplasm [GO:0005737]; membrane [GO:0016020]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; membrane [GO:0016020]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; regulation of translational initiation [GO:0006446]	
Q7L1S5	reviewed	CHST9_HUMAN	Carbohydrate sulfotransferase 9 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 2) (GalNAc-4-ST2) (GalNAc4ST-2) (N-acetylgalactosamine-4-O-sulfotransferase 2)	CHST9 UNQ2549/PRO6175	Homo sapiens (Human)	443	FUNCTION: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.		carbohydrate biosynthetic process [GO:0016051]; chondroitin sulfate biosynthetic process [GO:0030206]; glycosaminoglycan metabolic process [GO:0030203]; hormone biosynthetic process [GO:0042446]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790]	extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	chondroitin 4-sulfotransferase activity [GO:0047756]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; sulfotransferase activity [GO:0008146]	extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; chondroitin 4-sulfotransferase activity [GO:0047756]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; sulfotransferase activity [GO:0008146]; carbohydrate biosynthetic process [GO:0016051]; chondroitin sulfate biosynthetic process [GO:0030206]; glycosaminoglycan metabolic process [GO:0030203]; hormone biosynthetic process [GO:0042446]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790]	SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q7L1T6	reviewed	NB5R4_HUMAN	Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R)	CYB5R4 NCB5OR	Homo sapiens (Human)	521	FUNCTION: NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.		bicarbonate transport [GO:0015701]; cell development [GO:0048468]; detection of oxygen [GO:0003032]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; reactive oxygen species metabolic process [GO:0072593]; response to antibiotic [GO:0046677]; superoxide metabolic process [GO:0006801]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]	cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [GO:0016653]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [GO:0016653]; bicarbonate transport [GO:0015701]; cell development [GO:0048468]; detection of oxygen [GO:0003032]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; reactive oxygen species metabolic process [GO:0072593]; response to antibiotic [GO:0046677]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:10611283, ECO:0000269|PubMed:15131110}. Note=Soluble protein.
Q7L1W4	reviewed	LRC8D_HUMAN	Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D)	LRRC8D LRRC5 UNQ213/PRO239	Homo sapiens (Human)	858	FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309). {ECO:0000250|UniProtKB:Q8BGR2, ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26530471, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:32415200, ECO:0000269|PubMed:33171122}.		aspartate transmembrane transport [GO:0015810]; cellular response to osmotic stress [GO:0071470]; intracellular glucose homeostasis [GO:0001678]; monoatomic anion transmembrane transport [GO:0098656]; protein hexamerization [GO:0034214]; signal transduction [GO:0007165]; taurine transport [GO:0015734]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]	volume-sensitive anion channel activity [GO:0005225]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]; volume-sensitive anion channel activity [GO:0005225]; aspartate transmembrane transport [GO:0015810]; cellular response to osmotic stress [GO:0071470]; intracellular glucose homeostasis [GO:0001678]; monoatomic anion transmembrane transport [GO:0098656]; protein hexamerization [GO:0034214]; signal transduction [GO:0007165]; taurine transport [GO:0015734]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:28193731}; Multi-pass membrane protein {ECO:0000269|PubMed:32415200}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24782309, ECO:0000305|PubMed:24790029}; Multi-pass membrane protein {ECO:0000269|PubMed:32415200}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029). Requires LRRC8A for expression at the cell membrane (PubMed:24790029). {ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029}.
Q7L266	reviewed	ASGL1_HUMAN	Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain]	ASRGL1 ALP CRASH	Homo sapiens (Human)	308	FUNCTION: Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. {ECO:0000269|PubMed:19839645, ECO:0000269|PubMed:27106100}.		asparagine catabolic process via L-aspartate [GO:0033345]; protein autoprocessing [GO:0016540]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]	asparaginase activity [GO:0004067]; beta-aspartyl-peptidase activity [GO:0008798]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; asparaginase activity [GO:0004067]; beta-aspartyl-peptidase activity [GO:0008798]; asparagine catabolic process via L-aspartate [GO:0033345]; protein autoprocessing [GO:0016540]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11984834, ECO:0000269|PubMed:27106100}. Note=Midpiece of sperm tail.
Q7L273	reviewed	KCTD9_HUMAN	BTB/POZ domain-containing protein KCTD9	KCTD9	Homo sapiens (Human)	389	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. {ECO:0000305}.		intracellular signal transduction [GO:0035556]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]		cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]; protein self-association [GO:0043621]	cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]; protein self-association [GO:0043621]; intracellular signal transduction [GO:0035556]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]	
Q7L2E3	reviewed	DHX30_HUMAN	ATP-dependent RNA helicase DHX30 (EC 3.6.4.13) (DEAH box protein 30)	DHX30 DDX30 KIAA0890	Homo sapiens (Human)	1194	FUNCTION: RNA-dependent helicase (PubMed:29100085). Plays an important role in the assembly of the mitochondrial large ribosomal subunit (PubMed:25683715, PubMed:29100085). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (PubMed:18063578). Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD (By similarity). {ECO:0000250|UniProtKB:Q5BJS0, ECO:0000250|UniProtKB:Q99PU8, ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:25683715, ECO:0000269|PubMed:29100085}.		central nervous system development [GO:0007417]; mitochondrial large ribosomal subunit assembly [GO:1902775]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ribonucleoprotein granule [GO:0035770]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ribonucleoprotein granule [GO:0035770]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; central nervous system development [GO:0007417]; mitochondrial large ribosomal subunit assembly [GO:1902775]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29100085}. Mitochondrion {ECO:0000269|PubMed:16825194, ECO:0000269|PubMed:29100085}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:16825194, ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:25683715}. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids (PubMed:16825194, PubMed:25683715). Relocalizes to stress granules upon heat stress (PubMed:29100085). {ECO:0000269|PubMed:16825194, ECO:0000269|PubMed:25683715, ECO:0000269|PubMed:29100085}.
Q7L2H7	reviewed	EIF3M_HUMAN	Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1)	EIF3M HFLB5 PCID1 GA17 PNAS-125	Homo sapiens (Human)	374	FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). {ECO:0000269|PubMed:15919898}.		cytoplasmic translational initiation [GO:0002183]; formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]	translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]; cytoplasmic translational initiation [GO:0002183]; formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
Q7L2J0	reviewed	MEPCE_HUMAN	7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog)	MEPCE BCDIN3	Homo sapiens (Human)	689	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; RNA methylation [GO:0001510]; snRNA metabolic process [GO:0016073]; snRNA modification [GO:0040031]	7SK snRNP [GO:0120259]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	7SK snRNA binding [GO:0097322]; O-methyltransferase activity [GO:0008171]; RNA 5'-methyltransferase activity [GO:1990276]; RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; snRNA binding [GO:0017069]	7SK snRNP [GO:0120259]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; 7SK snRNA binding [GO:0097322]; O-methyltransferase activity [GO:0008171]; RNA 5'-methyltransferase activity [GO:1990276]; RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; snRNA binding [GO:0017069]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; RNA methylation [GO:0001510]; snRNA metabolic process [GO:0016073]; snRNA modification [GO:0040031]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19906723}.
Q7L2R6	reviewed	ZN765_HUMAN	Zinc finger protein 765	ZNF765	Homo sapiens (Human)	523	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q7L2Z9	reviewed	CENPQ_HUMAN	Centromere protein Q (CENP-Q)	CENPQ C6orf139	Homo sapiens (Human)	268	FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}.		chromosome segregation [GO:0007059]; metaphase chromosome alignment [GO:0051310]; positive regulation of protein localization to kinetochore [GO:1905342]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromosome segregation [GO:0007059]; metaphase chromosome alignment [GO:0051310]; positive regulation of protein localization to kinetochore [GO:1905342]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16622420}. Chromosome, centromere {ECO:0000269|PubMed:16622420}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Q7L3B6	reviewed	CD37L_HUMAN	Hsp90 co-chaperone Cdc37-like 1 (Hsp90-associating relative of Cdc37)	CDC37L1 CDC37B HARC	Homo sapiens (Human)	337	FUNCTION: Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. {ECO:0000250}.		protein folding [GO:0006457]; protein stabilization [GO:0050821]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089]	heat shock protein binding [GO:0031072]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089]; heat shock protein binding [GO:0031072]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11413142}.
Q7L3V2	reviewed	BOP_HUMAN	Protein Bop (BH3-only protein) (Retrotransposon Gag-like protein 10)	RTL10 BOP C22orf29	Homo sapiens (Human)	364	FUNCTION: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity. {ECO:0000269|PubMed:23055042}.		mitochondrial outer membrane permeabilization [GO:0097345]; regulation of mitochondrial membrane potential [GO:0051881]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; mitochondrial outer membrane permeabilization [GO:0097345]; regulation of mitochondrial membrane potential [GO:0051881]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23055042}.
Q7L4E1	reviewed	MIGA2_HUMAN	Mitoguardin 2 (Protein FAM73B)	MIGA2 C9orf54 FAM73B PSEC0112	Homo sapiens (Human)	593	FUNCTION: Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}.		bone development [GO:0060348]; mitochondrial fusion [GO:0008053]	mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]	protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; bone development [GO:0060348]; mitochondrial fusion [GO:0008053]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:26711011}; Multi-pass membrane protein {ECO:0000255}.
Q7L4I2	reviewed	RSRC2_HUMAN	Arginine/serine-rich coiled-coil protein 2	RSRC2	Homo sapiens (Human)	434					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q7L4P6	reviewed	BEND5_HUMAN	BEN domain-containing protein 5	BEND5 C1orf165	Homo sapiens (Human)	421	FUNCTION: Acts as a transcriptional repressor (PubMed:23468431). {ECO:0000269|PubMed:23468431}.		negative regulation of DNA-templated transcription [GO:0045892]	Golgi apparatus [GO:0005794]	DNA binding [GO:0003677]	Golgi apparatus [GO:0005794]; DNA binding [GO:0003677]; negative regulation of DNA-templated transcription [GO:0045892]	
Q7L513	reviewed	FCRLA_HUMAN	Fc receptor-like A (Fc receptor homolog expressed in B-cells) (Fc receptor-like and mucin-like protein 1) (Fc receptor-like protein) (Fc receptor-related protein X) (FcRX)	FCRLA FCRL FCRL1 FCRLM1 FCRX FREB UNQ291/PRO329	Homo sapiens (Human)	359	FUNCTION: May be implicated in B-cell differentiation and lymphomagenesis. {ECO:0000269|PubMed:11754007, ECO:0000269|PubMed:11891275}.		cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]	cytoplasm [GO:0005737]	transmembrane signaling receptor activity [GO:0004888]	cytoplasm [GO:0005737]; transmembrane signaling receptor activity [GO:0004888]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11754007, ECO:0000269|PubMed:11891275, ECO:0000269|PubMed:15551350}. Note=Seems not to be secreted. {ECO:0000269|PubMed:11891275}.
Q7L523	reviewed	RRAGA_HUMAN	Ras-related GTP-binding protein A (Rag A) (RagA) (EC 3.6.5.-) (Adenovirus E3 14.7 kDa-interacting protein 1) (FIP-1)	RRAGA	Homo sapiens (Human)	313	FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:25936802, PubMed:31601764, PubMed:31601708). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagA/RRAGA is in its active form when GTP-bound RagA/RRAGA forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagA/RRAGA heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed:20381137, PubMed:24095279, PubMed:25936802, PubMed:32868926, PubMed:31601764, PubMed:31601708). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:25936802, PubMed:31601764, PubMed:31601708). Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008). May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death (PubMed:8995684). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:25936802, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}.; FUNCTION: (Microbial infection) May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. {ECO:0000269|PubMed:8995684}.		apoptotic process [GO:0006915]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to nutrient levels [GO:0031669]; cellular response to starvation [GO:0009267]; glucose homeostasis [GO:0042593]; intracellular signal transduction [GO:0035556]; negative regulation of autophagy [GO:0010507]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; protein localization to lysosome [GO:0061462]; protein localization to membrane [GO:0072657]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; Gtr1-Gtr2 GTPase complex [GO:1990131]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phosphoprotein binding [GO:0051219]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; Gtr1-Gtr2 GTPase complex [GO:1990131]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phosphoprotein binding [GO:0051219]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to nutrient levels [GO:0031669]; cellular response to starvation [GO:0009267]; glucose homeostasis [GO:0042593]; intracellular signal transduction [GO:0035556]; negative regulation of autophagy [GO:0010507]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; protein localization to lysosome [GO:0061462]; protein localization to membrane [GO:0072657]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}. Nucleus {ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}. Lysosome membrane {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:31036939}. Note=Predominantly cytoplasmic (PubMed:8995684, PubMed:9394008). Recruited to the lysosome surface by the Ragulator complex (PubMed:20381137, PubMed:28935770, PubMed:29158492). May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state (PubMed:8995684, PubMed:9394008). Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane (PubMed:8995684). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}.
Q7L576	reviewed	CYFP1_HUMAN	Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)	CYFIP1 KIAA0068	Homo sapiens (Human)	1253	FUNCTION: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. {ECO:0000250|UniProtKB:Q7TMB8, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}.	MISCELLANEOUS: Breakpoint hotspot for the Prader-Willi/Angelman syndromes and may be implicated in autism. Commonly altered in tumors.	axon extension [GO:0048675]; axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; cellular response to insulin stimulus [GO:0032869]; cognition [GO:0050890]; dendrite extension [GO:0097484]; lamellipodium assembly [GO:0030032]; modification of synaptic structure [GO:0099563]; negative regulation of synaptic vesicle recycling [GO:1903422]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite development [GO:1900006]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of ruffle assembly [GO:1900029]; Rac protein signal transduction [GO:0016601]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of myelination [GO:0031641]; regulation of translation [GO:0006417]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; response to electrical stimulus [GO:0051602]; ruffle organization [GO:0031529]	axonal growth cone [GO:0044295]; central region of growth cone [GO:0090724]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium tip [GO:0032433]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mRNA cap binding complex [GO:0005845]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; peripheral region of growth cone [GO:0090725]; ruffle [GO:0001726]; SCAR complex [GO:0031209]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; synapse [GO:0045202]; terminal bouton [GO:0043195]; tertiary granule lumen [GO:1904724]	actin filament binding [GO:0051015]; RNA 7-methylguanosine cap binding [GO:0000340]; small GTPase binding [GO:0031267]	axonal growth cone [GO:0044295]; central region of growth cone [GO:0090724]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium tip [GO:0032433]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mRNA cap binding complex [GO:0005845]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; peripheral region of growth cone [GO:0090725]; ruffle [GO:0001726]; SCAR complex [GO:0031209]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; synapse [GO:0045202]; terminal bouton [GO:0043195]; tertiary granule lumen [GO:1904724]; actin filament binding [GO:0051015]; RNA 7-methylguanosine cap binding [GO:0000340]; small GTPase binding [GO:0031267]; axon extension [GO:0048675]; axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; cellular response to insulin stimulus [GO:0032869]; cognition [GO:0050890]; dendrite extension [GO:0097484]; lamellipodium assembly [GO:0030032]; modification of synaptic structure [GO:0099563]; negative regulation of synaptic vesicle recycling [GO:1903422]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite development [GO:1900006]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of ruffle assembly [GO:1900029]; Rac protein signal transduction [GO:0016601]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of myelination [GO:0031641]; regulation of translation [GO:0006417]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; response to electrical stimulus [GO:0051602]; ruffle organization [GO:0031529]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7TMB8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TMB8}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q7TMB8}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q7TMB8}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q7TMB8}. Note=Highly expressed in the perinuclear region (By similarity). Enriched in synaptosomes (By similarity). Also enriched in membrane ruffles and at the tips of lamellipodia (By similarity). {ECO:0000250|UniProtKB:Q7TMB8}.
Q7L590	reviewed	MCM10_HUMAN	Protein MCM10 homolog (HsMCM10)	MCM10 PRO2249	Homo sapiens (Human)	875	FUNCTION: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}.		cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; DNA replication initiation [GO:0006270]	nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA replication origin binding [GO:0003688]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]	nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA replication origin binding [GO:0003688]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; DNA replication initiation [GO:0006270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:32865517}. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.
Q7L591	reviewed	DOK3_HUMAN	Docking protein 3 (Downstream of tyrosine kinase 3)	DOK3	Homo sapiens (Human)	496	FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}.		positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]		cytoplasm [GO:0005737]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Q7L592	reviewed	NDUF7_HUMAN	Protein arginine methyltransferase NDUFAF7, mitochondrial (EC 2.1.1.320) (NADH dehydrogenase [ubiquinone] complex I, assembly factor 7) (Protein midA homolog)	NDUFAF7 C2orf56 PRO1853	Homo sapiens (Human)	441	FUNCTION: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:20406883, PubMed:24089531, PubMed:24838397). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex (PubMed:24089531). {ECO:0000269|PubMed:20406883, ECO:0000269|PubMed:24089531, ECO:0000269|PubMed:24838397}.		mitochondrial respiratory chain complex I assembly [GO:0032981]; peptidyl-arginine methylation, to symmetrical-dimethyl arginine [GO:0019918]	extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	enzyme binding [GO:0019899]; methyltransferase activity [GO:0008168]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243]	extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; enzyme binding [GO:0019899]; methyltransferase activity [GO:0008168]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243]; mitochondrial respiratory chain complex I assembly [GO:0032981]; peptidyl-arginine methylation, to symmetrical-dimethyl arginine [GO:0019918]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20406883, ECO:0000269|PubMed:24089531, ECO:0000269|PubMed:24838397, ECO:0000269|PubMed:28837730}.
Q7L5A3	reviewed	ATOSB_HUMAN	Atos homolog protein B	ATOSB FAM214B KIAA1539	Homo sapiens (Human)	538	FUNCTION: Transcription regulator that may syncronize transcriptional and translational programs. {ECO:0000250|UniProtKB:Q8BR27}.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7JXG9}.
Q7L5A8	reviewed	FA2H_HUMAN	Fatty acid 2-hydroxylase (EC 1.14.18.-) (Fatty acid alpha-hydroxylase) (Fatty acid hydroxylase domain-containing protein 1)	FA2H FAAH FAXDC1	Homo sapiens (Human)	372	FUNCTION: Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15337768, PubMed:15863841, PubMed:17355976, PubMed:22517924). FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (PubMed:22517924). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (PubMed:17355976). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (By similarity). Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity). {ECO:0000250|UniProtKB:Q5MPP0, ECO:0000269|PubMed:15337768, ECO:0000269|PubMed:15863841, ECO:0000269|PubMed:17355976, ECO:0000269|PubMed:22517924}.		central nervous system myelin maintenance [GO:0032286]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; galactosylceramide biosynthetic process [GO:0006682]; glucosylceramide biosynthetic process [GO:0006679]; lipid modification [GO:0030258]; peripheral nervous system myelin maintenance [GO:0032287]; plasma membrane raft organization [GO:0044857]; regulation of acinar cell proliferation [GO:1904697]; regulation of hair cycle [GO:0042634]; regulation of sebum secreting cell proliferation [GO:1904002]; sebaceous gland cell differentiation [GO:0001949]; sphingolipid biosynthetic process [GO:0030148]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	fatty acid alpha-hydroxylase activity [GO:0080132]; heme binding [GO:0020037]; iron ion binding [GO:0005506]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; fatty acid alpha-hydroxylase activity [GO:0080132]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; central nervous system myelin maintenance [GO:0032286]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; galactosylceramide biosynthetic process [GO:0006682]; glucosylceramide biosynthetic process [GO:0006679]; lipid modification [GO:0030258]; peripheral nervous system myelin maintenance [GO:0032287]; plasma membrane raft organization [GO:0044857]; regulation of acinar cell proliferation [GO:1904697]; regulation of hair cycle [GO:0042634]; regulation of sebum secreting cell proliferation [GO:1904002]; sebaceous gland cell differentiation [GO:0001949]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5MPP0}; Multi-pass membrane protein {ECO:0000269|PubMed:15337768}. Microsome membrane {ECO:0000269|PubMed:15337768}; Multi-pass membrane protein {ECO:0000269|PubMed:15337768}.
Q7L5D6	reviewed	GET4_HUMAN	Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35)	GET4 C7orf20 CEE TRC35 CGI-20	Homo sapiens (Human)	327	FUNCTION: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892, ECO:0000269|PubMed:32395830}.		cytoplasmic sequestering of protein [GO:0051220]; maintenance of unfolded protein involved in ERAD pathway [GO:1904378]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein insertion into ER membrane [GO:0045048]; regulation of protein stability [GO:0031647]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent protein catabolic process [GO:0006511]	BAT3 complex [GO:0071818]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	protein-folding chaperone binding [GO:0051087]	BAT3 complex [GO:0071818]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-folding chaperone binding [GO:0051087]; cytoplasmic sequestering of protein [GO:0051220]; maintenance of unfolded protein involved in ERAD pathway [GO:1904378]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein insertion into ER membrane [GO:0045048]; regulation of protein stability [GO:0031647]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:29042515, ECO:0000269|PubMed:32395830}.
Q7L5L3	reviewed	GDPD3_HUMAN	Lysophospholipase D GDPD3 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 7) (Glycerophosphodiester phosphodiesterase domain-containing protein 3)	GDPD3 GDE7	Homo sapiens (Human)	318	FUNCTION: Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. {ECO:0000250|UniProtKB:Q99LY2, ECO:0000269|PubMed:27637550}.		glycerophospholipid catabolic process [GO:0046475]; N-acylethanolamine metabolic process [GO:0070291]; phosphatidylcholine catabolic process [GO:0034638]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]	lysophospholipase activity [GO:0004622]; metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; lysophospholipase activity [GO:0004622]; metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081]; glycerophospholipid catabolic process [GO:0046475]; N-acylethanolamine metabolic process [GO:0070291]; phosphatidylcholine catabolic process [GO:0034638]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q99LY2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q99LY2}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q99LY2}. Endoplasmic reticulum {ECO:0000269|PubMed:27637550}. Note=Partially co-localized with CANX. {ECO:0000250|UniProtKB:Q99LY2}.
Q7L5N1	reviewed	CSN6_HUMAN	COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)	COPS6 CSN6 HVIP	Homo sapiens (Human)	327	FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:9535219}.		protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]		COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9535219}. Cytoplasm {ECO:0000269|PubMed:9535219}.; SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:9520381}. Note=(Microbial infection) The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region. {ECO:0000269|PubMed:9520381}.
Q7L5N7	reviewed	PCAT2_HUMAN	Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha)	LPCAT2 AGPAT11 AYTL1	Homo sapiens (Human)	544	FUNCTION: Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:20363836, PubMed:21498505). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:20363836). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198). {ECO:0000250|UniProtKB:Q8BYI6, ECO:0000269|PubMed:17182612, ECO:0000269|PubMed:20363836, ECO:0000269|PubMed:21498505, ECO:0000269|PubMed:25491198}.		membrane organization [GO:0061024]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; platelet activating factor biosynthetic process [GO:0006663]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-alkenylglycerophosphocholine O-acyltransferase activity [GO:0047159]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; calcium ion binding [GO:0005509]; lysophosphatidic acid acyltransferase activity [GO:0042171]; plasmalogen synthase activity [GO:0050200]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-alkenylglycerophosphocholine O-acyltransferase activity [GO:0047159]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; calcium ion binding [GO:0005509]; lysophosphatidic acid acyltransferase activity [GO:0042171]; plasmalogen synthase activity [GO:0050200]; membrane organization [GO:0061024]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; platelet activating factor biosynthetic process [GO:0006663]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20363836, ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8BYI6}; Single-pass type II membrane protein {ECO:0000305|PubMed:21498505}. Cell membrane {ECO:0000250|UniProtKB:Q8BYI6}; Single-pass type II membrane protein {ECO:0000305|PubMed:21498505}. Lipid droplet {ECO:0000269|PubMed:21498505}.
Q7L5Y1	reviewed	ENOF1_HUMAN	Mitochondrial enolase superfamily member 1 (EC 4.2.1.68) (Antisense RNA to thymidylate synthase) (rTS) (L-fuconate dehydratase)	ENOSF1 RTS TYMSAS	Homo sapiens (Human)	443	FUNCTION: Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329). {ECO:0000269|PubMed:24697329}.		amino acid catabolic process [GO:0009063]; carbohydrate catabolic process [GO:0016052]	mitochondrion [GO:0005739]	hydro-lyase activity [GO:0016836]; isomerase activity [GO:0016853]; L-fuconate dehydratase activity [GO:0050023]; magnesium ion binding [GO:0000287]	mitochondrion [GO:0005739]; hydro-lyase activity [GO:0016836]; isomerase activity [GO:0016853]; L-fuconate dehydratase activity [GO:0050023]; magnesium ion binding [GO:0000287]; amino acid catabolic process [GO:0009063]; carbohydrate catabolic process [GO:0016052]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16162288}.
Q7L5Y6	reviewed	DET1_HUMAN	DET1 homolog (De-etiolated-1 homolog)	DET1	Homo sapiens (Human)	550	FUNCTION: Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. {ECO:0000269|PubMed:14739464}.		positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cullin-RING ubiquitin ligase complex [GO:0031461]; nucleus [GO:0005634]	protein-containing complex binding [GO:0044877]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cullin-RING ubiquitin ligase complex [GO:0031461]; nucleus [GO:0005634]; protein-containing complex binding [GO:0044877]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q7L5Y9	reviewed	MAEA_HUMAN	E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP)	MAEA EMP HLC10 PIG5	Homo sapiens (Human)	396	FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable). {ECO:0000250|UniProtKB:Q4VC33, ECO:0000269|PubMed:29911972, ECO:0000269|PubMed:9763581, ECO:0000305|PubMed:16510120}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; cytoskeleton organization [GO:0007010]; enucleate erythrocyte development [GO:0048822]; erythrocyte maturation [GO:0043249]; negative regulation of myeloid cell apoptotic process [GO:0033033]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of mitotic cell cycle [GO:0007346]	actomyosin contractile ring [GO:0005826]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; GID complex [GO:0034657]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; ubiquitin ligase complex [GO:0000151]	actin binding [GO:0003779]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	actomyosin contractile ring [GO:0005826]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; GID complex [GO:0034657]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; ubiquitin ligase complex [GO:0000151]; actin binding [GO:0003779]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; cytoskeleton organization [GO:0007010]; enucleate erythrocyte development [GO:0048822]; erythrocyte maturation [GO:0043249]; negative regulation of myeloid cell apoptotic process [GO:0033033]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q4VC33}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:29911972}. Nucleus matrix {ECO:0000269|PubMed:16510120}. Cell membrane {ECO:0000269|PubMed:9763581}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16510120}. Note=Detected in a nuclear, speckled-like pattern (PubMed:16510120). Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis (PubMed:16510120). Present in cytoplasm, nuclear matrix and at the cell surface in macrophages; predominantly nuclear in immature macrophages and predominantly detected at the cell surface in mature macrophages. Colocalizes with F-actin in macrophages (By similarity). {ECO:0000250|UniProtKB:Q4VC33, ECO:0000269|PubMed:16510120}.
Q7L622	reviewed	G2E3_HUMAN	G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase)	G2E3 KIAA1333	Homo sapiens (Human)	706	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death. {ECO:0000269|PubMed:18511420}.		apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:17239372}. Cytoplasm {ECO:0000269|PubMed:17239372}. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage. {ECO:0000269|PubMed:17239372}.
Q7L775	reviewed	EPMIP_HUMAN	EPM2A-interacting protein 1 (Laforin-interacting protein)	EPM2AIP1 KIAA0766 My007	Homo sapiens (Human)	607			glycogen biosynthetic process [GO:0005978]; positive regulation of glycogen biosynthetic process [GO:0045725]; response to insulin [GO:0032868]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; glycogen biosynthetic process [GO:0005978]; positive regulation of glycogen biosynthetic process [GO:0045725]; response to insulin [GO:0032868]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:12782127}.
Q7L7L0	reviewed	H2A3_HUMAN	Histone H2A type 3 (H2A-clustered histone 25)	H2AC25 H2AW HIST3H2A	Homo sapiens (Human)	130	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		nucleosome disassembly [GO:0006337]; UV-damage excision repair [GO:0070914]	extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; nucleosome disassembly [GO:0006337]; UV-damage excision repair [GO:0070914]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q7L7V1	reviewed	DHX32_HUMAN	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC 3.6.4.13) (DEAD/H box 32) (DEAD/H helicase-like protein 1) (DHLP1) (DEAH box protein 32) (HuDDX32)	DHX32 DDX32	Homo sapiens (Human)	743				mitochondrion [GO:0005739]; spliceosomal complex [GO:0005681]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	mitochondrion [GO:0005739]; spliceosomal complex [GO:0005681]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16959245}. Mitochondrion {ECO:0000269|PubMed:16959245}.
Q7L7X3	reviewed	TAOK1_HUMAN	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1)	TAOK1 KIAA1361 MAP3K16 MARKK	Homo sapiens (Human)	1001	FUNCTION: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}.		central nervous system neuron development [GO:0021954]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; execution phase of apoptosis [GO:0097194]; microtubule cytoskeleton organization [GO:0000226]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of microtubule depolymerization [GO:0007026]; neuron cellular homeostasis [GO:0070050]; phosphorylation [GO:0016310]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein acetylation [GO:1901985]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule cytoskeleton organization [GO:0070507]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; perinuclear region of cytoplasm [GO:0048471]	alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; transferase activity [GO:0016740]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; perinuclear region of cytoplasm [GO:0048471]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; transferase activity [GO:0016740]; central nervous system neuron development [GO:0021954]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; execution phase of apoptosis [GO:0097194]; microtubule cytoskeleton organization [GO:0000226]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of microtubule depolymerization [GO:0007026]; neuron cellular homeostasis [GO:0070050]; phosphorylation [GO:0016310]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein acetylation [GO:1901985]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule cytoskeleton organization [GO:0070507]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:13679851}.
Q7L804	reviewed	RFIP2_HUMAN	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11)	RAB11FIP2 KIAA0941	Homo sapiens (Human)	512	FUNCTION: A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:30883606}.		establishment of cell polarity [GO:0030010]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; phagocytosis [GO:0006909]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulated exocytosis [GO:0045055]; TRAM-dependent toll-like receptor 4 signaling pathway [GO:0035669]	cell projection [GO:0042995]; cytoplasmic vesicle membrane [GO:0030659]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; recycling endosome membrane [GO:0055038]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]	cell projection [GO:0042995]; cytoplasmic vesicle membrane [GO:0030659]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; recycling endosome membrane [GO:0055038]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]; establishment of cell polarity [GO:0030010]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; phagocytosis [GO:0006909]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulated exocytosis [GO:0045055]; TRAM-dependent toll-like receptor 4 signaling pathway [GO:0035669]	SUBCELLULAR LOCATION: Cell projection, phagocytic cup {ECO:0000269|PubMed:30883606}. Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
Q7L8A9	reviewed	VASH1_HUMAN	Tubulinyl-Tyr carboxypeptidase 1 (EC 3.4.17.17) (Tubulin carboxypeptidase 1) (Tyrosine carboxypeptidase 1) (TTCP 1) (Vasohibin-1)	VASH1 KIAA1036 VASH	Homo sapiens (Human)	365	FUNCTION: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869, PubMed:31270470, PubMed:31235910, PubMed:31171830, PubMed:31235911). Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096). {ECO:0000269|PubMed:15467828, ECO:0000269|PubMed:16488400, ECO:0000269|PubMed:16707096, ECO:0000269|PubMed:19204325, ECO:0000269|PubMed:29146869, ECO:0000269|PubMed:31171830, ECO:0000269|PubMed:31235910, ECO:0000269|PubMed:31235911, ECO:0000269|PubMed:31270470}.		angiogenesis [GO:0001525]; cell cycle [GO:0007049]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of lymphangiogenesis [GO:1901491]; proteolysis [GO:0006508]; regulation of angiogenesis [GO:0045765]; regulation of cell cycle [GO:0051726]; regulation of cellular senescence [GO:2000772]; response to wounding [GO:0009611]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]	actin binding [GO:0003779]; metallocarboxypeptidase activity [GO:0004181]; tubulin-tyrosine carboxypeptidase [GO:0106423]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; actin binding [GO:0003779]; metallocarboxypeptidase activity [GO:0004181]; tubulin-tyrosine carboxypeptidase [GO:0106423]; angiogenesis [GO:0001525]; cell cycle [GO:0007049]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of lymphangiogenesis [GO:1901491]; proteolysis [GO:0006508]; regulation of angiogenesis [GO:0045765]; regulation of cell cycle [GO:0051726]; regulation of cellular senescence [GO:2000772]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15467828, ECO:0000269|PubMed:27879017}. Secreted {ECO:0000269|PubMed:15467828, ECO:0000269|PubMed:16707096, ECO:0000269|PubMed:20736312, ECO:0000269|PubMed:27879017}. Note=Mainly localizes in the cytoplasm (PubMed:27879017). Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:27879017). {ECO:0000269|PubMed:27879017}.
Q7L8J4	reviewed	3BP5L_HUMAN	SH3 domain-binding protein 5-like (SH3BP-5-like)	SH3BP5L KIAA1720 UNQ2766/PRO7133	Homo sapiens (Human)	393	FUNCTION: Functions as guanine nucleotide exchange factor (GEF) for RAB11A. {ECO:0000269|PubMed:30217979}.		intracellular signal transduction [GO:0035556]	cytoplasm [GO:0005737]	guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase inhibitor activity [GO:0004860]	cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase inhibitor activity [GO:0004860]; intracellular signal transduction [GO:0035556]	
Q7L8L6	reviewed	FAKD5_HUMAN	FAST kinase domain-containing protein 5, mitochondrial	FASTKD5 KIAA1792	Homo sapiens (Human)	764	FUNCTION: Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715). {ECO:0000269|PubMed:25683715}.		mitochondrial RNA processing [GO:0000963]; mRNA processing [GO:0006397]; regulation of mitochondrial mRNA stability [GO:0044528]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; mitochondrial RNA processing [GO:0000963]; mRNA processing [GO:0006397]; regulation of mitochondrial mRNA stability [GO:0044528]	SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:25683715}. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269|PubMed:25683715}.
Q7L8S5	reviewed	OTU6A_HUMAN	OTU domain-containing protein 6A (EC 3.4.19.12) (DUBA-2)	OTUD6A DUBA2	Homo sapiens (Human)	288	FUNCTION: Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. {ECO:0000269|PubMed:23827681}.		protein K11-linked deubiquitination [GO:0035871]; protein K27-linked deubiquitination [GO:1990167]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]		cysteine-type deubiquitinase activity [GO:0004843]	cysteine-type deubiquitinase activity [GO:0004843]; protein K11-linked deubiquitination [GO:0035871]; protein K27-linked deubiquitination [GO:1990167]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]	
Q7L9L4	reviewed	MOB1B_HUMAN	MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A)	MOB1B MOB4A MOBKL1A	Homo sapiens (Human)	216	FUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}.		hippo signaling [GO:0035329]; positive regulation of protein phosphorylation [GO:0001934]; regulation of protein autophosphorylation [GO:0031952]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	kinase activator activity [GO:0019209]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; kinase activator activity [GO:0019209]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; hippo signaling [GO:0035329]; positive regulation of protein phosphorylation [GO:0001934]; regulation of protein autophosphorylation [GO:0031952]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15067004}. Nucleus {ECO:0000269|PubMed:15067004}.
Q7LBC6	reviewed	KDM3B_HUMAN	Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B)	KDM3B C5orf7 JHDM2B JMJD1B KIAA1082	Homo sapiens (Human)	1761	FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}.	MISCELLANEOUS: Its gene is located in the 5q region of the genome which is deleted in del(5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del(5q) tumor suppressor gene.	regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]	antioxidant activity [GO:0016209]; chromatin DNA binding [GO:0031490]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; antioxidant activity [GO:0016209]; chromatin DNA binding [GO:0031490]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q7LBE3	reviewed	S26A9_HUMAN	Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9)	SLC26A9	Homo sapiens (Human)	791	FUNCTION: Ion transporter that can act both as an ion channel and anion exchanger (PubMed:15800055, PubMed:17673510, PubMed:26801567, PubMed:32818062). Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane (PubMed:17673510, PubMed:26801567, PubMed:32818062). Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane (PubMed:11834742, PubMed:15800055). {ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:15800055, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:26801567, ECO:0000269|PubMed:32818062}.		chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; positive regulation of gene expression [GO:0010628]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	ATPase binding [GO:0051117]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; ATPase binding [GO:0051117]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; positive regulation of gene expression [GO:0010628]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:26801567}; Multi-pass membrane protein {ECO:0000269|PubMed:32818062}. Endomembrane system {ECO:0000269|PubMed:26801567}; Multi-pass membrane protein {ECO:0000269|PubMed:32818062}. Note=Localization to the cell membrane is inhibited by WNK kinases (WNK1, WNK2, WNK3 or WNK4) in a kinase-independent mechanism. {ECO:0000269|PubMed:17673510}.
Q7LBR1	reviewed	CHM1B_HUMAN	Charged multivesicular body protein 1b (CHMP1.5) (Chromatin-modifying protein 1b) (CHMP1b) (Vacuolar protein sorting-associated protein 46-2) (Vps46-2) (hVps46-2)	CHMP1B C18orf2	Homo sapiens (Human)	199	FUNCTION: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:19129479}.		autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; MIT domain binding [GO:0090541]; protein domain specific binding [GO:0019904]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; MIT domain binding [GO:0090541]; protein domain specific binding [GO:0019904]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Endosome. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body.
Q7LC44	reviewed	ARC_HUMAN	Activity-regulated cytoskeleton-associated protein (hArc) (Activity-regulated gene 3.1 protein homolog) (ARC/ARG3.1) (Arg3.1)	ARC KIAA0278	Homo sapiens (Human)	396	FUNCTION: Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (By similarity). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity). {ECO:0000250|UniProtKB:Q63053, ECO:0000250|UniProtKB:Q9WV31}.		anterior/posterior pattern specification [GO:0009952]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; dendritic spine morphogenesis [GO:0060997]; endocytosis [GO:0006897]; endoderm development [GO:0007492]; learning [GO:0007612]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; modulation of chemical synaptic transmission [GO:0050804]; mRNA transport [GO:0051028]; protein homooligomerization [GO:0051260]; regulation of cell morphogenesis [GO:0022604]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of long-term synaptic depression [GO:1900452]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; vesicle-mediated intercellular transport [GO:0110077]	acrosomal vesicle [GO:0001669]; actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; extracellular vesicle [GO:1903561]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; neuronal ribonucleoprotein granule [GO:0071598]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic endosome [GO:0098845]	mRNA binding [GO:0003729]	acrosomal vesicle [GO:0001669]; actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; extracellular vesicle [GO:1903561]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; neuronal ribonucleoprotein granule [GO:0071598]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic endosome [GO:0098845]; mRNA binding [GO:0003729]; anterior/posterior pattern specification [GO:0009952]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; dendritic spine morphogenesis [GO:0060997]; endocytosis [GO:0006897]; endoderm development [GO:0007492]; learning [GO:0007612]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; modulation of chemical synaptic transmission [GO:0050804]; mRNA transport [GO:0051028]; protein homooligomerization [GO:0051260]; regulation of cell morphogenesis [GO:0022604]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of long-term synaptic depression [GO:1900452]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; vesicle-mediated intercellular transport [GO:0110077]	SUBCELLULAR LOCATION: Extracellular vesicle membrane {ECO:0000250|UniProtKB:Q63053}; Lipid-anchor {ECO:0000250|UniProtKB:Q9WV31}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9WV31}; Lipid-anchor {ECO:0000250|UniProtKB:Q9WV31}. Synapse {ECO:0000250|UniProtKB:Q63053}. Postsynaptic density {ECO:0000250|UniProtKB:Q63053}. Early endosome membrane {ECO:0000250|UniProtKB:Q63053}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63053}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21834987}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q63053}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q63053}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9WV31}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:24945773}. Note=Forms virion-like extracellular vesicles that are released from neurons. Enriched in postsynaptic density of dendritic spines. Targeted to inactive synapses following interaction with CAMK2B in the kinase inactive state. Accumulation at weaker synapses may be required to prevent their undesired enhancement. Associated with the cell cortex of neuronal soma and dendrites (By similarity). Associated with the sperm tail (By similarity). {ECO:0000250|UniProtKB:Q63053, ECO:0000250|UniProtKB:Q9WV31}.
Q7LDG7	reviewed	GRP2_HUMAN	RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein)	RASGRP2 CDC25L MCG7	Homo sapiens (Human)	609	FUNCTION: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}.	MISCELLANEOUS: [Isoform 3]: The corresponding protein is not undetectable. {ECO:0000305}.	cellular response to calcium ion [GO:0071277]; positive regulation of GTPase activity [GO:0043547]; Ras protein signal transduction [GO:0007265]; regulation of cell growth [GO:0001558]; signal transduction [GO:0007165]	cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; synapse [GO:0045202]	calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289]	cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289]; cellular response to calcium ion [GO:0071277]; positive regulation of GTPase activity [GO:0043547]; Ras protein signal transduction [GO:0007265]; regulation of cell growth [GO:0001558]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Synapse, synaptosome {ECO:0000305}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Found both in the cytosol and associated with membranes. Isoform 2 mainly localizes to the cell membrane. Enriched at juxtamembrane areas and membrane ruffles through association with F-actin. Localizes to the cell bodies and axons of striatal neurons (By similarity). {ECO:0000250}.
Q7LFL8	reviewed	CXXC5_HUMAN	CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF)	CXXC5 HSPC195 TCCCIA00297	Homo sapiens (Human)	322	FUNCTION: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q5XIQ3, ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330, ECO:0000269|PubMed:23303788, ECO:0000269|PubMed:29276034}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; methyl-CpG binding [GO:0008327]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; methyl-CpG binding [GO:0008327]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330}. Cytoplasm {ECO:0000250|UniProtKB:Q5XIQ3}. Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane. {ECO:0000250|UniProtKB:Q5XIQ3}.
Q7LFX5	reviewed	CHSTF_HUMAN	Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (hBRAG) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST)	CHST15 BRAG GALNAC4S6ST KIAA0598	Homo sapiens (Human)	561	FUNCTION: Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo. {ECO:0000269|PubMed:11572857, ECO:0000269|PubMed:12874280}.		chondroitin sulfate biosynthetic process [GO:0030206]; hexose biosynthetic process [GO:0019319]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity [GO:0050659]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity [GO:0050659]; chondroitin sulfate biosynthetic process [GO:0030206]; hexose biosynthetic process [GO:0019319]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:10749872}; Single-pass type II membrane protein {ECO:0000305|PubMed:10749872}. Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.
Q7LG56	reviewed	RIR2B_HUMAN	Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)	RRM2B P53R2	Homo sapiens (Human)	351	FUNCTION: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {ECO:0000269|PubMed:10716435, ECO:0000269|PubMed:11517226, ECO:0000269|PubMed:11719458}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	2'-deoxyribonucleotide biosynthetic process [GO:0009265]; deoxyribonucleoside triphosphate metabolic process [GO:0009200]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; kidney development [GO:0001822]; mitochondrial DNA replication [GO:0006264]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; renal system process [GO:0003014]; response to amine [GO:0014075]; response to oxidative stress [GO:0006979]; ribonucleoside diphosphate metabolic process [GO:0009185]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoside-diphosphate reductase complex [GO:0005971]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoside-diphosphate reductase complex [GO:0005971]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]; 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; deoxyribonucleoside triphosphate metabolic process [GO:0009200]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; kidney development [GO:0001822]; mitochondrial DNA replication [GO:0006264]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; renal system process [GO:0003014]; response to amine [GO:0014075]; response to oxidative stress [GO:0006979]; ribonucleoside diphosphate metabolic process [GO:0009185]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage.
Q7LGA3	reviewed	HS2ST_HUMAN	Heparan sulfate 2-O-sulfotransferase 1 (2-O-sulfotransferase) (2OST) (EC 2.8.2.-)	HS2ST1 HS2ST KIAA0448	Homo sapiens (Human)	356	FUNCTION: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). {ECO:0000250}.		gene expression [GO:0010467]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin metabolic process [GO:0030202]; ureteric bud formation [GO:0060676]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	heparan sulfate 2-O-sulfotransferase activity [GO:0004394]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; heparan sulfate 2-O-sulfotransferase activity [GO:0004394]; gene expression [GO:0010467]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin metabolic process [GO:0030202]; ureteric bud formation [GO:0060676]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q7LGC8	reviewed	CHST3_HUMAN	Carbohydrate sulfotransferase 3 (EC 2.8.2.17) (EC 2.8.2.21) (Chondroitin 6-O-sulfotransferase 1) (C6ST-1) (Chondroitin 6-sulfotransferase) (C6ST) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0) (GST-0)	CHST3	Homo sapiens (Human)	479	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin (PubMed:9714738, PubMed:9883891, PubMed:15215498). Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices (PubMed:9714738). Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan (PubMed:9714738). Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides (By similarity). May play a role in the maintenance of naive T-lymphocytes in the spleen (By similarity). {ECO:0000250|UniProtKB:O88199, ECO:0000250|UniProtKB:Q92179, ECO:0000269|PubMed:15215498, ECO:0000269|PubMed:9714738, ECO:0000269|PubMed:9883891, ECO:0000303|PubMed:9714738}.		carbohydrate metabolic process [GO:0005975]; chondroitin sulfate biosynthetic process [GO:0030206]; N-acetylglucosamine metabolic process [GO:0006044]; sulfur compound metabolic process [GO:0006790]; T cell homeostasis [GO:0043029]	Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	chondroitin 6-sulfotransferase activity [GO:0008459]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; proteoglycan sulfotransferase activity [GO:0050698]	Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; chondroitin 6-sulfotransferase activity [GO:0008459]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; proteoglycan sulfotransferase activity [GO:0050698]; carbohydrate metabolic process [GO:0005975]; chondroitin sulfate biosynthetic process [GO:0030206]; N-acetylglucosamine metabolic process [GO:0006044]; sulfur compound metabolic process [GO:0006790]; T cell homeostasis [GO:0043029]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q7RTN6	reviewed	STRAA_HUMAN	STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96)	STRADA LYK5 STRAD	Homo sapiens (Human)	431	FUNCTION: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:19892943}.		activation of protein kinase activity [GO:0032147]; G1 to G0 transition [GO:0070314]; protein export from nucleus [GO:0006611]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular protein-containing complex [GO:0140535]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554]	ATP binding [GO:0005524]; kinase binding [GO:0019900]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activator activity [GO:0043539]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular protein-containing complex [GO:0140535]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554]; ATP binding [GO:0005524]; kinase binding [GO:0019900]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activator activity [GO:0043539]; activation of protein kinase activity [GO:0032147]; G1 to G0 transition [GO:0070314]; protein export from nucleus [GO:0006611]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248}. Cytoplasm {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248}.
Q7RTP0	reviewed	NIPA1_HUMAN	Magnesium transporter NIPA1 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 1) (Spastic paraplegia 6 protein)	NIPA1 SPG6	Homo sapiens (Human)	329	FUNCTION: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Zn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). {ECO:0000250|UniProtKB:Q8BHK1}.		magnesium ion transport [GO:0015693]; transmembrane transport [GO:0055085]	early endosome [GO:0005769]; membrane [GO:0016020]; plasma membrane [GO:0005886]	magnesium ion transmembrane transporter activity [GO:0015095]	early endosome [GO:0005769]; membrane [GO:0016020]; plasma membrane [GO:0005886]; magnesium ion transmembrane transporter activity [GO:0015095]; magnesium ion transport [GO:0015693]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BHK1}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000250|UniProtKB:Q8BHK1}. Note=Recruited to the cell membrane in response to low extracellular magnesium. {ECO:0000250|UniProtKB:Q8BHK1}.
Q7RTP6	reviewed	MICA3_HUMAN	[F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3)	MICAL3 KIAA0819 KIAA1364	Homo sapiens (Human)	2002	FUNCTION: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}.		actin filament depolymerization [GO:0030042]; cell cycle [GO:0007049]; cell division [GO:0051301]; cytoskeleton organization [GO:0007010]; exocytosis [GO:0006887]; localization [GO:0051179]	cell cortex [GO:0005938]; cell projection [GO:0042995]; cytosol [GO:0005829]; Flemming body [GO:0090543]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]	actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]	cell cortex [GO:0005938]; cell projection [GO:0042995]; cytosol [GO:0005829]; Flemming body [GO:0090543]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; actin filament depolymerization [GO:0030042]; cell cycle [GO:0007049]; cell division [GO:0051301]; cytoskeleton organization [GO:0007010]; exocytosis [GO:0006887]; localization [GO:0051179]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15694364}. Cytoplasm, cell cortex {ECO:0000269|PubMed:21596566}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15694364}. Nucleus {ECO:0000269|PubMed:24440334}. Midbody {ECO:0000269|PubMed:27528609}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:27528609}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000305|PubMed:26485645}. Note=Mainly localizes in the nucleus. {ECO:0000269|PubMed:24440334}.
Q7RTR0	reviewed	NLRP9_HUMAN	NACHT, LRR and PYD domains-containing protein 9 (Nucleotide-binding oligomerization domain protein 6) (PYRIN and NACHT-containing protein 12)	NLRP9 NALP9 NOD6 PAN12	Homo sapiens (Human)	991	FUNCTION: As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments. {ECO:0000269|PubMed:28636595}.		defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of interleukin-18 production [GO:0032741]; pyroptosis [GO:0070269]; regulation of inflammatory response [GO:0050727]	canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]	ATP binding [GO:0005524]	canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; ATP binding [GO:0005524]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of interleukin-18 production [GO:0032741]; pyroptosis [GO:0070269]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q66X22}. Inflammasome {ECO:0000269|PubMed:28636595}.
Q7RTR2	reviewed	NLRC3_HUMAN	NLR family CARD domain-containing protein 3 (CARD15-like protein) (Caterpiller protein 16.2) (CLR16.2) (NACHT, LRR and CARD domains-containing protein 3) (Nucleotide-binding oligomerization domain protein 3)	NLRC3 NOD3	Homo sapiens (Human)	1065	FUNCTION: Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106). {ECO:0000250|UniProtKB:Q5DU56, ECO:0000269|PubMed:15705585, ECO:0000269|PubMed:22863753, ECO:0000269|PubMed:25277106}.		canonical NF-kappaB signal transduction [GO:0007249]; intracellular signal transduction [GO:0035556]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of tumor necrosis factor production [GO:0032720]; T cell activation [GO:0042110]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; canonical NF-kappaB signal transduction [GO:0007249]; intracellular signal transduction [GO:0035556]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of tumor necrosis factor production [GO:0032720]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15705585, ECO:0000269|PubMed:24560620, ECO:0000269|PubMed:25277106}.
Q7RTS1	reviewed	BHA15_HUMAN	Class A basic helix-loop-helix protein 15 (bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1)	BHLHA15 BHLHB8 MIST1	Homo sapiens (Human)	189	FUNCTION: Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity). {ECO:0000250|UniProtKB:Q9QYC3}.		axon development [GO:0061564]; calcium-mediated signaling [GO:0019722]; cell-cell signaling [GO:0007267]; cellular response to glucose starvation [GO:0042149]; endoplasmic reticulum unfolded protein response [GO:0030968]; establishment of localization in cell [GO:0051649]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; Golgi organization [GO:0007030]; intracellular distribution of mitochondria [GO:0048312]; mitochondrial calcium ion transmembrane transport [GO:0006851]; negative regulation of myotube differentiation [GO:0010832]; neuron fate commitment [GO:0048663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; type B pancreatic cell maturation [GO:0072560]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]; axon development [GO:0061564]; calcium-mediated signaling [GO:0019722]; cell-cell signaling [GO:0007267]; cellular response to glucose starvation [GO:0042149]; endoplasmic reticulum unfolded protein response [GO:0030968]; establishment of localization in cell [GO:0051649]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; Golgi organization [GO:0007030]; intracellular distribution of mitochondria [GO:0048312]; mitochondrial calcium ion transmembrane transport [GO:0006851]; negative regulation of myotube differentiation [GO:0010832]; neuron fate commitment [GO:0048663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; type B pancreatic cell maturation [GO:0072560]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q7RTS3	reviewed	PTF1A_HUMAN	Pancreas transcription factor 1 subunit alpha (Class A basic helix-loop-helix protein 29) (bHLHa29) (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA-binding subunit of transcription factor PTF1) (PTF1-p48)	PTF1A BHLHA29 PTF1P48	Homo sapiens (Human)	328	FUNCTION: Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. {ECO:0000269|PubMed:10768861, ECO:0000269|PubMed:15543146}.	MISCELLANEOUS: An excellent marker of acinar cell differentiation in the pancreas.	amacrine cell differentiation [GO:0035881]; cerebellum development [GO:0021549]; developmental process [GO:0032502]; exocrine pancreas development [GO:0031017]; neuron fate commitment [GO:0048663]; pancreas development [GO:0031016]; regulation of DNA-templated transcription [GO:0006355]; regulation of neural retina development [GO:0061074]; regulation of transcription by RNA polymerase II [GO:0006357]; retina layer formation [GO:0010842]; retinoic acid receptor signaling pathway [GO:0048384]; tissue development [GO:0009888]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; amacrine cell differentiation [GO:0035881]; cerebellum development [GO:0021549]; developmental process [GO:0032502]; exocrine pancreas development [GO:0031017]; neuron fate commitment [GO:0048663]; pancreas development [GO:0031016]; regulation of DNA-templated transcription [GO:0006355]; regulation of neural retina development [GO:0061074]; regulation of transcription by RNA polymerase II [GO:0006357]; retina layer formation [GO:0010842]; retinoic acid receptor signaling pathway [GO:0048384]; tissue development [GO:0009888]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. Cytoplasm {ECO:0000250}. Note=In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex (By similarity). {ECO:0000250}.
Q7RTS7	reviewed	K2C74_HUMAN	Keratin, type II cytoskeletal 74 (Cytokeratin-74) (CK-74) (Keratin-5c) (K5C) (Keratin-74) (K74) (Type II inner root sheath-specific keratin-K6irs4) (Type-II keratin Kb37)	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	Homo sapiens (Human)	529	FUNCTION: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]	keratin filament binding [GO:1990254]; structural constituent of skin epidermis [GO:0030280]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; keratin filament binding [GO:1990254]; structural constituent of skin epidermis [GO:0030280]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
Q7RTS9	reviewed	DYM_HUMAN	Dymeclin (Dyggve-Melchior-Clausen syndrome protein)	DYM	Homo sapiens (Human)	669	FUNCTION: Necessary for correct organization of Golgi apparatus. Involved in bone development. {ECO:0000269|PubMed:21280149}.		bone development [GO:0060348]; Golgi organization [GO:0007030]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	enzyme binding [GO:0019899]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; enzyme binding [GO:0019899]; bone development [GO:0060348]; Golgi organization [GO:0007030]	SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Sequence analysis programs clearly predict 1 transmembrane region. However, PubMed:18996921 shows that it is not a stably anchored transmembrane protein but it weakly associates with the Golgi apparatus and shuttles between the Golgi and the cytosol.
Q7RTT9	reviewed	S29A4_HUMAN	Equilibrative nucleoside transporter 4 (hENT4) (Plasma membrane monoamine transporter) (PMAT) (Solute carrier family 29 member 4)	SLC29A4 ENT4 PMAT PSEC0113	Homo sapiens (Human)	530	FUNCTION: Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:15448143, PubMed:16099839, PubMed:16873718, PubMed:17018840, PubMed:17121826, PubMed:20592246, PubMed:20858707, PubMed:22396231, PubMed:31537831). Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations (PubMed:15448143, PubMed:20592246, PubMed:22396231). Functions as a Na(+)- and Cl(-)-independent bidirectional transporter (PubMed:15448143, PubMed:16099839, PubMed:22396231, PubMed:31537831). Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure (PubMed:16873718, PubMed:17018840, PubMed:20592246, PubMed:22396231, PubMed:31537831). Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system (PubMed:15448143, PubMed:16099839, PubMed:17018840, PubMed:17121826, PubMed:20858707, PubMed:22396231). Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (By similarity). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (PubMed:16873718, PubMed:20592246, PubMed:31537831). May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney (PubMed:17018840). Also transports guanidine (PubMed:16099839). {ECO:0000250|UniProtKB:Q8R139, ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16099839, ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:17121826, ECO:0000269|PubMed:20592246, ECO:0000269|PubMed:20858707, ECO:0000269|PubMed:22396231, ECO:0000269|PubMed:31537831}.	MISCELLANEOUS: Does not interact with nucleosides, nucleobases or nucleotides, other than a moderate activity for adenosine (PubMed:15448143, PubMed:17393420, PubMed:20592246). Mediates the uptake of neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) (PubMed:15448143, PubMed:16099839, PubMed:17018840, PubMed:17121826, PubMed:20592246, PubMed:20858707, PubMed:23255610). {ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16099839, ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:17121826, ECO:0000269|PubMed:17393420, ECO:0000269|PubMed:20592246, ECO:0000269|PubMed:20858707, ECO:0000269|PubMed:23255610}.	adenosine transport [GO:0032238]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; epinephrine uptake [GO:0051625]; export across plasma membrane [GO:0140115]; histamine metabolic process [GO:0001692]; histamine transport [GO:0051608]; histamine uptake [GO:0051615]; monoamine transport [GO:0015844]; monoatomic cation transmembrane transport [GO:0098655]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; organic acid transmembrane transport [GO:1903825]; organic cation transport [GO:0015695]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; toxin transport [GO:1901998]; transport across blood-brain barrier [GO:0150104]; xenobiotic transport [GO:0042908]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	efflux transmembrane transporter activity [GO:0015562]; monoamine transmembrane transporter activity [GO:0008504]; monoatomic cation transmembrane transporter activity [GO:0008324]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleoside transmembrane transporter activity [GO:0005337]; organic acid transmembrane transporter activity [GO:0005342]; organic cation transmembrane transporter activity [GO:0015101]; toxin transmembrane transporter activity [GO:0019534]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; efflux transmembrane transporter activity [GO:0015562]; monoamine transmembrane transporter activity [GO:0008504]; monoatomic cation transmembrane transporter activity [GO:0008324]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleoside transmembrane transporter activity [GO:0005337]; organic acid transmembrane transporter activity [GO:0005342]; organic cation transmembrane transporter activity [GO:0015101]; toxin transmembrane transporter activity [GO:0019534]; xenobiotic transmembrane transporter activity [GO:0042910]; adenosine transport [GO:0032238]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; epinephrine uptake [GO:0051625]; export across plasma membrane [GO:0140115]; histamine metabolic process [GO:0001692]; histamine transport [GO:0051608]; histamine uptake [GO:0051615]; monoamine transport [GO:0015844]; monoatomic cation transmembrane transport [GO:0098655]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; organic acid transmembrane transport [GO:1903825]; organic cation transport [GO:0015695]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; toxin transport [GO:1901998]; transport across blood-brain barrier [GO:0150104]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17121826, ECO:0000269|PubMed:20858707}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:23255610}; Multi-pass membrane protein {ECO:0000305}. Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells (PubMed:16873718). Targeted to the apical membranes of differentiated kidney epithelial cells (PubMed:17018840). Localized to the apical blood-cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelium (PubMed:23255610). {ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:23255610}.
Q7RTU1	reviewed	TCF23_HUMAN	Transcription factor 23 (TCF-23) (Class A basic helix-loop-helix protein 24) (bHLHa24)	TCF23 BHLHA24	Homo sapiens (Human)	214	FUNCTION: Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; decidualization [GO:0046697]; developmental process [GO:0032502]; muscle organ development [GO:0007517]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator inhibitor activity [GO:0140416]	chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator inhibitor activity [GO:0140416]; cell differentiation [GO:0030154]; decidualization [GO:0046697]; developmental process [GO:0032502]; muscle organ development [GO:0007517]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q7RTU3	reviewed	OLIG3_HUMAN	Oligodendrocyte transcription factor 3 (Oligo3) (Class B basic helix-loop-helix protein 7) (bHLHb7) (Class E basic helix-loop-helix protein 20) (bHLHe20)	OLIG3 BHLHB7 BHLHE20	Homo sapiens (Human)	272	FUNCTION: May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.		axon development [GO:0061564]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; spinal cord motor neuron cell fate specification [GO:0021520]; spinal cord motor neuron migration [GO:0097476]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]; axon development [GO:0061564]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; spinal cord motor neuron cell fate specification [GO:0021520]; spinal cord motor neuron migration [GO:0097476]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q7RTU4	reviewed	BHA09_HUMAN	Class A basic helix-loop-helix protein 9 (bHLHa9) (Class F basic helix-loop-helix factor 42) (bHLHf42)	BHLHA9 BHLHF42	Homo sapiens (Human)	235	FUNCTION: Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis. {ECO:0000269|PubMed:22147889, ECO:0000269|PubMed:25466284}.		developmental process [GO:0032502]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; developmental process [GO:0032502]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. Cytoplasm {ECO:0000269|PubMed:25466284}.
Q7RTU7	reviewed	SCX_HUMAN	Basic helix-loop-helix transcription factor scleraxis (Class A basic helix-loop-helix protein 41) (bHLHa41) (Class A basic helix-loop-helix protein 48) (bHLHa48)	SCX BHLHA41 BHLHA48 SCXA SCXB	Homo sapiens (Human)	201	FUNCTION: Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages. {ECO:0000250}.		BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; deltoid tuberosity development [GO:0035993]; developmental process [GO:0032502]; DNA-templated transcription [GO:0006351]; embryonic skeletal system development [GO:0048706]; endochondral ossification [GO:0001958]; face morphogenesis [GO:0060325]; heart valve formation [GO:0003188]; heart valve morphogenesis [GO:0003179]; mesoderm formation [GO:0001707]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gastrulation [GO:2000543]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cartilage development [GO:0061035]; regulation of transcription by RNA polymerase II [GO:0006357]; sclerotome development [GO:0061056]; Sertoli cell differentiation [GO:0060008]; skeletal muscle cell differentiation [GO:0035914]; tendon cell differentiation [GO:0035990]; tendon development [GO:0035989]; tendon formation [GO:0035992]; tissue homeostasis [GO:0001894]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	bHLH transcription factor binding [GO:0043425]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; bHLH transcription factor binding [GO:0043425]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; deltoid tuberosity development [GO:0035993]; developmental process [GO:0032502]; DNA-templated transcription [GO:0006351]; embryonic skeletal system development [GO:0048706]; endochondral ossification [GO:0001958]; face morphogenesis [GO:0060325]; heart valve formation [GO:0003188]; heart valve morphogenesis [GO:0003179]; mesoderm formation [GO:0001707]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gastrulation [GO:2000543]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cartilage development [GO:0061035]; regulation of transcription by RNA polymerase II [GO:0006357]; sclerotome development [GO:0061056]; Sertoli cell differentiation [GO:0060008]; skeletal muscle cell differentiation [GO:0035914]; tendon cell differentiation [GO:0035990]; tendon development [GO:0035989]; tendon formation [GO:0035992]; tissue homeostasis [GO:0001894]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q7RTV0	reviewed	PHF5A_HUMAN	PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b)	PHF5A	Homo sapiens (Human)	110	FUNCTION: Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes. Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies. Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity). Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643, PubMed:28541300). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (By similarity). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000250|UniProtKB:P83870, ECO:0000250|UniProtKB:P83871, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300, ECO:0000305|PubMed:33509932}.		mRNA splicing, via spliceosome [GO:0000398]; positive regulation of DNA-templated transcription [GO:0045893]; stem cell differentiation [GO:0048863]; U2-type prespliceosome assembly [GO:1903241]	nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	DNA binding [GO:0003677]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of DNA-templated transcription [GO:0045893]; stem cell differentiation [GO:0048863]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300}. Nucleus speckle {ECO:0000250|UniProtKB:P83870}.
Q7RTW8	reviewed	OTOAN_HUMAN	Otoancorin	OTOA	Homo sapiens (Human)	1153	FUNCTION: May act as an adhesion molecule.		cell-matrix adhesion [GO:0007160]; sensory perception of sound [GO:0007605]; transmission of nerve impulse [GO:0019226]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell-matrix adhesion [GO:0007160]; sensory perception of sound [GO:0007605]; transmission of nerve impulse [GO:0019226]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}; Extracellular side {ECO:0000305}. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Note=At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes. {ECO:0000250}.
Q7RTX0	reviewed	TS1R3_HUMAN	Taste receptor type 1 member 3 (Sweet taste receptor T1R3)	TAS1R3 T1R3 TR3	Homo sapiens (Human)	852	FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. {ECO:0000250, ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:12892531}.		detection of chemical stimulus involved in sensory perception of sweet taste [GO:0001582]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sweet taste receptor complex [GO:1903767]	G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sweet taste receptor complex [GO:1903767]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of sweet taste [GO:0001582]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q7RTX1	reviewed	TS1R1_HUMAN	Taste receptor type 1 member 1 (G-protein coupled receptor 70)	TAS1R1 GPR70 T1R1 TR1 GM148	Homo sapiens (Human)	841	FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. {ECO:0000269|PubMed:11917125}.	MISCELLANEOUS: [Isoform 4]: Incomplete sequence. {ECO:0000305}.	sensory perception of umami taste [GO:0050917]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; sensory perception of umami taste [GO:0050917]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q7RTX7	reviewed	CTSR4_HUMAN	Cation channel sperm-associated protein 4 (CatSper4)	CATSPER4	Homo sapiens (Human)	472	FUNCTION: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.		establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transport [GO:0006814]; sperm capacitation [GO:0048240]	acrosomal vesicle [GO:0001669]; CatSper complex [GO:0036128]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]	calcium activated cation channel activity [GO:0005227]; voltage-gated calcium channel activity [GO:0005245]	acrosomal vesicle [GO:0001669]; CatSper complex [GO:0036128]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]; calcium activated cation channel activity [GO:0005227]; voltage-gated calcium channel activity [GO:0005245]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transport [GO:0006814]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q8BVN3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8BVN3}. Note=Specifically located in the principal piece of the sperm tail. {ECO:0000250|UniProtKB:Q8BVN3}.
Q7RTY0	reviewed	MOT13_HUMAN	Monocarboxylate transporter 13 (MCT 13) (Solute carrier family 16 member 13)	SLC16A13 MCT13	Homo sapiens (Human)	426	FUNCTION: Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. {ECO:0000305|PubMed:12739169}.		monocarboxylic acid transport [GO:0015718]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]; monocarboxylic acid transport [GO:0015718]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:24390345}; Multi-pass membrane protein {ECO:0000269|PubMed:24390345}. Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q7RTY1	reviewed	MOT9_HUMAN	Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9)	SLC16A9 C10orf36 MCT9	Homo sapiens (Human)	509	FUNCTION: Extracellular pH-and Na(+)-sensitive low-affinity creatine transporter (PubMed:31784090). Functions also as a pH-independent carnitine efflux transporter (PubMed:21886157). {ECO:0000269|PubMed:21886157, ECO:0000269|PubMed:31784090}.		carnitine transmembrane transport [GO:1902603]; creatine transmembrane transport [GO:0015881]; monocarboxylic acid transport [GO:0015718]; urate metabolic process [GO:0046415]	plasma membrane [GO:0005886]	carnitine transmembrane transporter activity [GO:0015226]; creatine transmembrane transporter activity [GO:0005308]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]	plasma membrane [GO:0005886]; carnitine transmembrane transporter activity [GO:0015226]; creatine transmembrane transporter activity [GO:0005308]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]; carnitine transmembrane transport [GO:1902603]; creatine transmembrane transport [GO:0015881]; monocarboxylic acid transport [GO:0015718]; urate metabolic process [GO:0046415]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31784090}; Multi-pass membrane protein {ECO:0000255}.
Q7RTZ1	reviewed	OVCH2_HUMAN	Ovochymase-2 (EC 3.4.21.-) (Oviductin)	OVCH2 OVTN	Homo sapiens (Human)	564	FUNCTION: May be required for sperm ADAM3 processing and consequential sperm fertilizing ability (By similarity). In vitro, has an endopeptidase activity (PubMed:32499443). {ECO:0000250|UniProtKB:Q7M761, ECO:0000269|PubMed:32499443}.		fertilization [GO:0009566]; proteolysis [GO:0006508]	extracellular region [GO:0005576]	metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; fertilization [GO:0009566]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P79953}.
Q7Z2D5	reviewed	PLPR4_HUMAN	Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1)	PLPPR4 KIAA0455 LPPR4 PHP1 PRG1	Homo sapiens (Human)	763	FUNCTION: Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity). {ECO:0000250|UniProtKB:Q7TMB7, ECO:0000250|UniProtKB:Q7TME0}.		axonogenesis [GO:0007409]; G protein-coupled receptor signaling pathway [GO:0007186]; inner ear development [GO:0048839]; lipid import into cell [GO:0140354]; phospholipid metabolic process [GO:0006644]; regulation of synaptic transmission, glutamatergic [GO:0051966]; signal transduction [GO:0007165]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	phosphatidate phosphatase activity [GO:0008195]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; phosphatidate phosphatase activity [GO:0008195]; axonogenesis [GO:0007409]; G protein-coupled receptor signaling pathway [GO:0007186]; inner ear development [GO:0048839]; lipid import into cell [GO:0140354]; phospholipid metabolic process [GO:0006644]; regulation of synaptic transmission, glutamatergic [GO:0051966]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Postsynaptic density membrane {ECO:0000269|PubMed:26671989}; Multi-pass membrane protein {ECO:0000255}.
Q7Z2E3	reviewed	APTX_HUMAN	Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT)	APTX AXA1	Homo sapiens (Human)	356	FUNCTION: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). {ECO:0000250|UniProtKB:O74859, ECO:0000269|PubMed:15044383, ECO:0000269|PubMed:15380105, ECO:0000269|PubMed:16547001, ECO:0000269|PubMed:16964241, ECO:0000269|PubMed:17276982, ECO:0000269|PubMed:24362567}.	MISCELLANEOUS: [Isoform 1]: Major form. {ECO:0000305|PubMed:14755728}.; MISCELLANEOUS: [Isoform 2]: Minor form. {ECO:0000305|PubMed:14755728}.; MISCELLANEOUS: [Isoform 3]: May be an aberrant isoform present in cancer cell lines. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be an aberrant isoform present in cancer cell lines. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be an aberrant isoform present in cancer cell lines. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: May be an aberrant isoform present in cancer cell lines. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: May be an aberrant isoform present in cancer cell lines. {ECO:0000305}.; MISCELLANEOUS: [Isoform 10]: May be an aberrant isoform present in cancer cell lines. {ECO:0000305}.	DNA ligation [GO:0006266]; regulation of protein stability [GO:0031647]; single strand break repair [GO:0000012]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA 5'-adenosine monophosphate hydrolase activity [GO:0033699]; DNA-3'-diphospho-5'-guanosine diphosphatase [GO:0120108]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; mismatched DNA binding [GO:0030983]; phosphoglycolate phosphatase activity [GO:0008967]; phosphoprotein binding [GO:0051219]; polynucleotide 3'-phosphatase activity [GO:0046403]; single-strand break-containing DNA binding [GO:1990165]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA 5'-adenosine monophosphate hydrolase activity [GO:0033699]; DNA-3'-diphospho-5'-guanosine diphosphatase [GO:0120108]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; mismatched DNA binding [GO:0030983]; phosphoglycolate phosphatase activity [GO:0008967]; phosphoprotein binding [GO:0051219]; polynucleotide 3'-phosphatase activity [GO:0046403]; single-strand break-containing DNA binding [GO:1990165]; single-stranded DNA binding [GO:0003697]; DNA ligation [GO:0006266]; regulation of protein stability [GO:0031647]; single strand break repair [GO:0000012]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:14755728, ECO:0000269|PubMed:15044383, ECO:0000269|PubMed:15276230, ECO:0000269|PubMed:15380105}. Nucleus, nucleolus {ECO:0000269|PubMed:15044383, ECO:0000269|PubMed:16777843}. Note=Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage (PubMed:15380105). Colocalizes with MDC1 at sites of DNA double-strand breaks (PubMed:20008512). Interaction with NCL is required for nucleolar localization (PubMed:16777843). {ECO:0000269|PubMed:15044383, ECO:0000269|PubMed:15380105, ECO:0000269|PubMed:20008512}.; SUBCELLULAR LOCATION: [Isoform 12]: Cytoplasm {ECO:0000269|PubMed:15276230}.
Q7Z2H8	reviewed	S36A1_HUMAN	Proton-coupled amino acid transporter 1 (Proton/amino acid transporter 1) (hPAT1) (Solute carrier family 36 member 1)	SLC36A1 PAT1	Homo sapiens (Human)	476	FUNCTION: Electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA (PubMed:12809675, PubMed:12527723, PubMed:19549785). May be involved in the efflux from the lysosomal compartment of neutral amino acids resulting from proteolysis (By similarity). May play a role in specifying sites for exocytosis in neurons (By similarity). {ECO:0000250|UniProtKB:Q924A5, ECO:0000269|PubMed:12527723, ECO:0000269|PubMed:12809675, ECO:0000269|PubMed:19549785}.		alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine transport [GO:0015808]; monoatomic ion transport [GO:0006811]; proline transmembrane transport [GO:0035524]; proline transport [GO:0015824]; proton transmembrane transport [GO:1902600]; taurine transport [GO:0015734]	apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]	alanine transmembrane transporter activity [GO:0022858]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:proton symporter activity [GO:0005280]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; proline:proton symporter activity [GO:0005297]; taurine transmembrane transporter activity [GO:0005368]	apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]; alanine transmembrane transporter activity [GO:0022858]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:proton symporter activity [GO:0005280]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; proline:proton symporter activity [GO:0005297]; taurine transmembrane transporter activity [GO:0005368]; alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine transport [GO:0015808]; monoatomic ion transport [GO:0006811]; proline transmembrane transport [GO:0035524]; proline transport [GO:0015824]; proton transmembrane transport [GO:1902600]; taurine transport [GO:0015734]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12527723, ECO:0000269|PubMed:12809675, ECO:0000269|PubMed:19549785}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12527723}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000255}. Note=In neurons, colocalizes with the exocyst complex in the axonal processes. {ECO:0000250|UniProtKB:Q924A5}.
Q7Z2K6	reviewed	ERMP1_HUMAN	Endoplasmic reticulum metallopeptidase 1 (EC 3.4.-.-) (Felix-ina)	ERMP1 FXNA KIAA1815	Homo sapiens (Human)	904	FUNCTION: Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. {ECO:0000250|UniProtKB:Q6UPR8}.		cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum unfolded protein response [GO:0030968]; proteolysis [GO:0006508]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	metal ion binding [GO:0046872]; metalloexopeptidase activity [GO:0008235]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; metal ion binding [GO:0046872]; metalloexopeptidase activity [GO:0008235]; cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum unfolded protein response [GO:0030968]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6UPR8}; Multi-pass membrane protein {ECO:0000255}.
Q7Z2W4	reviewed	ZCCHV_HUMAN	Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)	ZC3HAV1 ZC3HDC2 PRO1677	Homo sapiens (Human)	902	FUNCTION: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q8K3Y6}. Nucleus {ECO:0000250|UniProtKB:Q8K3Y6}. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250|UniProtKB:Q8K3Y6}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:21102435}.
Q7Z2W7	reviewed	TRPM8_HUMAN	Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8)	TRPM8 LTRPC6 TRPP8	Homo sapiens (Human)	1104	FUNCTION: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. {ECO:0000269|PubMed:15306801, ECO:0000269|PubMed:16174775, ECO:0000269|PubMed:22128173, ECO:0000269|PubMed:25559186}.	MISCELLANEOUS: The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein.; MISCELLANEOUS: Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers.	calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to cold [GO:0009409]; thermoception [GO:0050955]	endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]	endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]; calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to cold [GO:0009409]; thermoception [GO:0050955]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells. {ECO:0000250}.
Q7Z2X4	reviewed	PCLI1_HUMAN	PTB-containing, cubilin and LRP1-interacting protein (P-CLI1) (Phosphotyrosine interaction domain-containing protein 1) (Protein NYGGF4)	PID1 NYGGF4 PCLI1 HMFN2073	Homo sapiens (Human)	250	FUNCTION: Increases proliferation of preadipocytes without affecting adipocytic differentiation. {ECO:0000269|PubMed:16815647}.		cellular response to cytokine stimulus [GO:0071345]; cellular response to fatty acid [GO:0071398]; cellular response to interleukin-6 [GO:0071354]; cellular response to leptin stimulus [GO:0044320]; cellular response to tumor necrosis factor [GO:0071356]; energy reserve metabolic process [GO:0006112]; mitochondrion morphogenesis [GO:0070584]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of glucose import [GO:0046325]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of fat cell proliferation [GO:0070346]; positive regulation of gene expression [GO:0010628]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitochondrial fusion [GO:0010635]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; cellular response to cytokine stimulus [GO:0071345]; cellular response to fatty acid [GO:0071398]; cellular response to interleukin-6 [GO:0071354]; cellular response to leptin stimulus [GO:0044320]; cellular response to tumor necrosis factor [GO:0071356]; energy reserve metabolic process [GO:0006112]; mitochondrion morphogenesis [GO:0070584]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of glucose import [GO:0046325]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of fat cell proliferation [GO:0070346]; positive regulation of gene expression [GO:0010628]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitochondrial fusion [GO:0010635]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16815647}.
Q7Z2Y5	reviewed	NRK_HUMAN	Nik-related protein kinase (EC 2.7.11.1)	NRK	Homo sapiens (Human)	1582	FUNCTION: May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). {ECO:0000250}.		phosphorylation [GO:0016310]		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	
Q7Z2Z1	reviewed	TICRR_HUMAN	Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein)	TICRR C15orf42	Homo sapiens (Human)	1910	FUNCTION: Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.		DNA repair [GO:0006281]; DNA replication [GO:0006260]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; regulation of DNA-templated DNA replication initiation [GO:0030174]; response to ionizing radiation [GO:0010212]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; regulation of DNA-templated DNA replication initiation [GO:0030174]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20080954}. Note=Associates with chromatin.
Q7Z2Z2	reviewed	EFL1_HUMAN	Elongation factor-like GTPase 1 (Elongation factor Tu GTP-binding domain-containing protein 1) (Elongation factor-like 1) (Protein FAM42A)	EFL1 EFTUD1 FAM42A	Homo sapiens (Human)	1120	FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits. {ECO:0000269|PubMed:21536732}.		cytosolic ribosome assembly [GO:0042256]; GTP metabolic process [GO:0046039]	cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746]	cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746]; cytosolic ribosome assembly [GO:0042256]; GTP metabolic process [GO:0046039]	
Q7Z333	reviewed	SETX_HUMAN	Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin)	SETX ALS4 KIAA0625 SCAR1	Homo sapiens (Human)	2677	FUNCTION: Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}.		cell differentiation [GO:0030154]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to oxidative stress [GO:0034599]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA-templated transcription termination [GO:0006353]; double-strand break repair [GO:0006302]; fibroblast growth factor receptor signaling pathway [GO:0008543]; MAPK cascade [GO:0000165]; mRNA splice site recognition [GO:0006376]; negative regulation of apoptotic process [GO:0043066]; nervous system development [GO:0007399]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of neuron projection development [GO:0010976]; positive regulation of RNA splicing [GO:0033120]; positive regulation of termination of DNA-templated transcription [GO:0060566]; positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000806]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA processing [GO:0006396]; spermatogenesis [GO:0007283]; termination of RNA polymerase II transcription [GO:0006369]	axon [GO:0030424]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription termination site sequence-specific DNA binding [GO:0001147]	axon [GO:0030424]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription termination site sequence-specific DNA binding [GO:0001147]; cell differentiation [GO:0030154]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to oxidative stress [GO:0034599]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA-templated transcription termination [GO:0006353]; double-strand break repair [GO:0006302]; fibroblast growth factor receptor signaling pathway [GO:0008543]; MAPK cascade [GO:0000165]; mRNA splice site recognition [GO:0006376]; negative regulation of apoptotic process [GO:0043066]; nervous system development [GO:0007399]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of neuron projection development [GO:0010976]; positive regulation of RNA splicing [GO:0033120]; positive regulation of termination of DNA-templated transcription [GO:0060566]; positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000806]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA processing [GO:0006396]; spermatogenesis [GO:0007283]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:24105744}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17562789}. Nucleus, nucleolus {ECO:0000269|PubMed:17562789}. Cytoplasm {ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:21576111}. Chromosome {ECO:0000269|PubMed:23149945}. Chromosome, telomere {ECO:0000269|PubMed:21112256}. Cell projection, axon {ECO:0000269|PubMed:21576111}. Cell projection, growth cone {ECO:0000269|PubMed:21576111}. Note=May be detected in the nucleolus only in cycling cells. At pachytene stage, colocalizes predominantly to the heterochromatic XY-body of sex chromosomes with DNA damage response proteins in a BRCA1-dependent manner (By similarity). Localizes with telomeric DNA in a transcription-dependent manner (PubMed:21112256). Under replication stress, colocalizes with a variety of DNA damage signaling and repair response proteins at distinct nuclear foci in mitotic S/G2- and G1-phase cells in a transcription- and RNA/DNA hybrid-dependent manner (PubMed:23149945). Localizes at limited number of nuclear foci (PubMed:24105744). Colocalizes with EXOSC9 in nuclear foci upon induction of transcription-related DNA damage at the S phase (PubMed:24105744). Most abundant in the nucleus. Detected in granules. Colocalized in cycling cells with FBL in the nucleolus. {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:23149945, ECO:0000269|PubMed:24105744}.
Q7Z353	reviewed	HDX_HUMAN	Highly divergent homeobox	HDX CXorf43	Homo sapiens (Human)	690			regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q7Z392	reviewed	TPC11_HUMAN	Trafficking protein particle complex subunit 11	TRAPPC11 C4orf41	Homo sapiens (Human)	1133	FUNCTION: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:27862579}.		constitutive secretory pathway [GO:0045054]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; regulation of protein complex stability [GO:0061635]; vesicle tethering [GO:0099022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072]; constitutive secretory pathway [GO:0045054]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; regulation of protein complex stability [GO:0061635]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:27862579}. Golgi apparatus, cis-Golgi network {ECO:0000250}.
Q7Z3B1	reviewed	NEGR1_HUMAN	Neuronal growth regulator 1 (IgLON family member 4)	NEGR1 IGLON4 UNQ2433/PRO4993	Homo sapiens (Human)	354	FUNCTION: May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity). {ECO:0000250}.		cell-cell adhesion [GO:0098609]; feeding behavior [GO:0007631]; locomotory behavior [GO:0007626]; neuron projection development [GO:0031175]; positive regulation of neuron projection development [GO:0010976]; regulation of synapse assembly [GO:0051963]	dendrite [GO:0030425]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		dendrite [GO:0030425]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell-cell adhesion [GO:0098609]; feeding behavior [GO:0007631]; locomotory behavior [GO:0007626]; neuron projection development [GO:0031175]; positive regulation of neuron projection development [GO:0010976]; regulation of synapse assembly [GO:0051963]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Q7Z3B3	reviewed	KANL1_HUMAN	KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog)	KANSL1 CENP-36 KIAA1267 MSL1V1 NSL1	Homo sapiens (Human)	1105	FUNCTION: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone acetyltransferase binding [GO:0035035]	histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone acetyltransferase binding [GO:0035035]; chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20018852}. Nucleus. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
Q7Z3B4	reviewed	NUP54_HUMAN	Nucleoporin p54 (54 kDa nucleoporin)	NUP54	Homo sapiens (Human)	507	FUNCTION: Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {ECO:0000250|UniProtKB:P70582}.		mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein localization to nuclear inner membrane [GO:0036228]; protein targeting [GO:0006605]; regulation of protein import into nucleus [GO:0042306]	nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]	identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; structural constituent of nuclear pore [GO:0017056]	nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; structural constituent of nuclear pore [GO:0017056]; mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein localization to nuclear inner membrane [GO:0036228]; protein targeting [GO:0006605]; regulation of protein import into nucleus [GO:0042306]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P70582}. Nucleus membrane {ECO:0000250|UniProtKB:P70582}; Peripheral membrane protein {ECO:0000250|UniProtKB:P70582}; Cytoplasmic side {ECO:0000250|UniProtKB:P70582}. Nucleus membrane {ECO:0000250|UniProtKB:P70582}; Peripheral membrane protein {ECO:0000250|UniProtKB:P70582}; Nucleoplasmic side {ECO:0000250|UniProtKB:P70582}. Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter. {ECO:0000250|UniProtKB:P70582}.
Q7Z3C6	reviewed	ATG9A_HUMAN	Autophagy-related protein 9A (APG9-like 1) (mATG9)	ATG9A APG9L1	Homo sapiens (Human)	839	FUNCTION: Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:33468622, PubMed:33850023, PubMed:32610138, PubMed:33106659). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; bone morphogenesis [GO:0060349]; late nucleophagy [GO:0044805]; programmed necrotic cell death [GO:0097300]; protein localization to phagophore assembly site [GO:0034497]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]	phospholipid scramblase activity [GO:0017128]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; phospholipid scramblase activity [GO:0017128]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; bone morphogenesis [GO:0060349]; late nucleophagy [GO:0044805]; programmed necrotic cell death [GO:0097300]; protein localization to phagophore assembly site [GO:0034497]	SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33106659}; Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:19910472}; Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:20124090, ECO:0000269|PubMed:21068542, ECO:0000269|PubMed:27316455, ECO:0000269|PubMed:27663665, ECO:0000269|PubMed:29180427, ECO:0000269|PubMed:33468622, ECO:0000305|PubMed:34432599}; Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Late endosome membrane {ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:20124090, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:33468622}; Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Recycling endosome membrane {ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:29437695}; Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20124090, ECO:0000269|PubMed:27316455, ECO:0000269|PubMed:27663665}; Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Mitochondrion membrane {ECO:0000305|PubMed:34432599}; Multi-pass membrane protein {ECO:0000255}. Note=Mainly localizes to the trans-Golgi network (TGN) and the endosomal system; cycles between them though vesicle trafficking (PubMed:27316455, PubMed:27663665). Export from the TGN to promote formation of autophagosomes is mediated by the AP-4 complex (PubMed:29180427, PubMed:30262884). Under amino acid starvation or rapamycin treatment, redistributes to preautophagosomal structure/phagophore assembly site (PAS) (PubMed:16940348). The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1 (PubMed:16940348). Upon autophagy induction, a small portion transiently localizes to the autophagic membranes (PubMed:22456507). Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner (PubMed:34432599). {ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27316455, ECO:0000269|PubMed:27663665, ECO:0000269|PubMed:29180427, ECO:0000269|PubMed:30262884, ECO:0000269|PubMed:34432599}.
Q7Z3D4	reviewed	LYSM3_HUMAN	LysM and putative peptidoglycan-binding domain-containing protein 3	LYSMD3	Homo sapiens (Human)	306	FUNCTION: Essential for Golgi structural integrity. {ECO:0000269|PubMed:29851555}.		Golgi organization [GO:0007030]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	peptidoglycan binding [GO:0042834]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; peptidoglycan binding [GO:0042834]; Golgi organization [GO:0007030]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29851555}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:29851555}.
Q7Z3E1	reviewed	PARPT_HUMAN	Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase)	TIPARP PARP7	Homo sapiens (Human)	657	FUNCTION: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed:23275542, PubMed:30373764). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:30373764}.		androgen metabolic process [GO:0008209]; cellular response to organic cyclic compound [GO:0071407]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; female gonad development [GO:0008585]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; negative regulation of gene expression [GO:0010629]; nitrogen compound metabolic process [GO:0006807]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of protein catabolic process [GO:0045732]; post-embryonic development [GO:0009791]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745]; vasculogenesis [GO:0001570]	nucleus [GO:0005634]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]	nucleus [GO:0005634]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; androgen metabolic process [GO:0008209]; cellular response to organic cyclic compound [GO:0071407]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; female gonad development [GO:0008585]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; negative regulation of gene expression [GO:0010629]; nitrogen compound metabolic process [GO:0006807]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of protein catabolic process [GO:0045732]; post-embryonic development [GO:0009791]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:30373764}.
Q7Z3E5	reviewed	ARMC9_HUMAN	LisH domain-containing protein ARMC9 (Armadillo repeat-containing protein 9) (Melanoma/melanocyte-specific tumor antigen KU-MEL-1) (NS21)	ARMC9 KIAA1868	Homo sapiens (Human)	818	FUNCTION: Involved in ciliogenesis (PubMed:32453716). It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (PubMed:32453716). Acts as a positive regulator of hedgehog (Hh)signaling (By similarity). May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (By similarity). {ECO:0000250|UniProtKB:E7F187, ECO:0000250|UniProtKB:Q9D2I5, ECO:0000269|PubMed:32453716}.		cilium assembly [GO:0060271]; positive regulation of smoothened signaling pathway [GO:0045880]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]		centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; cilium assembly [GO:0060271]; positive regulation of smoothened signaling pathway [GO:0045880]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28625504}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9D2I5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28625504}. Note=Localized to the proximal region in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9 toward the ciliary tip within 6 hours, follow by a gradual return to its original proximal location (By similarity). Localizes to the daughter centriole of the primary cilium in RPE1 cells (PubMed:28625504). {ECO:0000250|UniProtKB:Q9D2I5, ECO:0000269|PubMed:28625504}.
Q7Z3F1	reviewed	LYCHS_HUMAN	Lysosomal cholesterol signaling protein (LYCHOS) (G-protein coupled receptor PGR22)	GPR155 PGR22	Homo sapiens (Human)	870	FUNCTION: Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (PubMed:36007018). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disrupt interaction between the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:36007018). Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition (PubMed:36007018). {ECO:0000269|PubMed:36007018}.		cellular response to amino acid starvation [GO:0034198]; cellular response to cholesterol [GO:0071397]; cognition [GO:0050890]; intracellular signal transduction [GO:0035556]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of TORC1 signaling [GO:1904263]; transmembrane transport [GO:0055085]	extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]	cholesterol binding [GO:0015485]	extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; cholesterol binding [GO:0015485]; cellular response to amino acid starvation [GO:0034198]; cellular response to cholesterol [GO:0071397]; cognition [GO:0050890]; intracellular signal transduction [GO:0035556]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of TORC1 signaling [GO:1904263]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:36007018}; Multi-pass membrane protein {ECO:0000255}.
Q7Z3H0	reviewed	PANKY_HUMAN	Photoreceptor ankyrin repeat protein (Ankyrin repeat domain-containing protein 33)	ANKRD33 C12orf7 PANKY	Homo sapiens (Human)	452	FUNCTION: Acts as a transcriptional repressor for CRX-activated photoreceptor gene regulation. {ECO:0000250|UniProtKB:Q8BXP5}.		skeletal muscle cell differentiation [GO:0035914]	cytosol [GO:0005829]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleus [GO:0005634]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8BXP5}. Nucleus {ECO:0000250|UniProtKB:Q8BXP5}.
Q7Z3I7	reviewed	ZN572_HUMAN	Zinc finger protein 572	ZNF572	Homo sapiens (Human)	529	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q7Z3J2	reviewed	VP35L_HUMAN	VPS35 endosomal protein-sorting factor-like (Esophageal cancer-associated protein)	VPS35L C16orf62 101F10.2	Homo sapiens (Human)	963	FUNCTION: Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947). {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.; FUNCTION: (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}.		endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031]	endosome [GO:0005768]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]		endosome [GO:0005768]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Endosome {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. Note=Endosome location is dependent of the association with the CCC and WASH complexes. {ECO:0000269|PubMed:28892079}.
Q7Z3K3	reviewed	POGZ_HUMAN	Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635)	POGZ KIAA0461 SUHW5 ZNF280E ZNF635 Nbla00003	Homo sapiens (Human)	1410	FUNCTION: Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}.		cell division [GO:0051301]; double-strand break repair via homologous recombination [GO:0000724]; kinetochore assembly [GO:0051382]; mitotic sister chromatid cohesion [GO:0007064]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; cell division [GO:0051301]; double-strand break repair via homologous recombination [GO:0000724]; kinetochore assembly [GO:0051382]; mitotic sister chromatid cohesion [GO:0007064]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26721387}. Chromosome. Cytoplasm. Note=According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3). {ECO:0000269|PubMed:19244240}.
Q7Z3K6	reviewed	MIER3_HUMAN	Mesoderm induction early response protein 3 (Mi-er3)	MIER3	Homo sapiens (Human)	550	FUNCTION: Transcriptional repressor. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.
Q7Z3Q1	reviewed	S46A3_HUMAN	Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)	SLC46A3 FKSG16	Homo sapiens (Human)	461	FUNCTION: Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (PubMed:36741448). Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (By similarity). Transports catabolites of non-cleavable antibody-drug conjugates from the lysosome to the cytoplasm (PubMed:26631267, PubMed:30131388, PubMed:36741448). Delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Selectively transports bacterial muramyl dipeptide (MDP) into the cytosol for recognition by NOD2, triggering inflammatory responses (By similarity). Likely acts as a redundant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable). {ECO:0000250|UniProtKB:Q9DC26, ECO:0000269|PubMed:26631267, ECO:0000269|PubMed:30131388, ECO:0000269|PubMed:34235268, ECO:0000269|PubMed:36741448, ECO:0000305}.		cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; vacuolar transmembrane transport [GO:0034486]	extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]	copper ion transmembrane transporter activity [GO:0005375]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]	extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; copper ion transmembrane transporter activity [GO:0005375]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]; cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; vacuolar transmembrane transport [GO:0034486]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:26631267, ECO:0000269|PubMed:35862544, ECO:0000269|PubMed:36741448}; Multi-pass membrane protein {ECO:0000255}.
Q7Z3S7	reviewed	CA2D4_HUMAN	Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4]	CACNA2D4	Homo sapiens (Human)	1137	FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000269|PubMed:12181424}.	MISCELLANEOUS: In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug.; MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	calcium ion transmembrane transport [GO:0070588]; detection of light stimulus involved in visual perception [GO:0050908]; regulation of monoatomic ion transmembrane transport [GO:0034765]	voltage-gated calcium channel complex [GO:0005891]	metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]	voltage-gated calcium channel complex [GO:0005891]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; calcium ion transmembrane transport [GO:0070588]; detection of light stimulus involved in visual perception [GO:0050908]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q7Z3S9	reviewed	NT2NA_HUMAN	Notch homolog 2 N-terminal-like protein A (Notch homolog 2 N-terminal-like protein)	NOTCH2NLA N2N NOTCH2NL	Homo sapiens (Human)	236	FUNCTION: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity). {ECO:0000250|UniProtKB:P0DPK3, ECO:0000269|PubMed:29561261, ECO:0000269|PubMed:29856954, ECO:0000269|PubMed:29856955}.		cell differentiation [GO:0030154]; cerebral cortex development [GO:0021987]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; Notch binding [GO:0005112]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; cell differentiation [GO:0030154]; cerebral cortex development [GO:0021987]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14673143, ECO:0000269|PubMed:29856954}. Cytoplasm {ECO:0000269|PubMed:14673143}.
Q7Z3T8	reviewed	ZFY16_HUMAN	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein)	ZFYVE16 KIAA0305	Homo sapiens (Human)	1539	FUNCTION: May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}.		endosomal transport [GO:0016197]; protein targeting to lysosome [GO:0006622]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165]; vesicle organization [GO:0016050]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]	1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; 1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; endosomal transport [GO:0016197]; protein targeting to lysosome [GO:0006622]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165]; vesicle organization [GO:0016050]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11546807}. Early endosome membrane {ECO:0000269|PubMed:11546807}; Peripheral membrane protein {ECO:0000269|PubMed:11546807}. Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).
Q7Z3U7	reviewed	MON2_HUMAN	Protein MON2 homolog (Protein SF21)	MON2 KIAA1040 SF21	Homo sapiens (Human)	1717	FUNCTION: Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}.		Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]		cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:30213940}.
Q7Z3Y7	reviewed	K1C28_HUMAN	Keratin, type I cytoskeletal 28 (Cytokeratin-28) (CK-28) (Keratin-25D) (K25D) (Keratin-28) (K28) (Type I inner root sheath-specific keratin-K25irs4)	KRT28 KRT25D	Homo sapiens (Human)	464	FUNCTION: Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs). {ECO:0000250|UniProtKB:A6BLY7}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). {ECO:0000305}.	epithelial cell differentiation [GO:0030855]; hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A6BLY7}.
Q7Z3Y8	reviewed	K1C27_HUMAN	Keratin, type I cytoskeletal 27 (Cytokeratin-27) (CK-27) (Keratin-25C) (K25C) (Keratin-27) (K27) (Type I inner root sheath-specific keratin-K25irs3)	KRT27 KRT25C	Homo sapiens (Human)	459	FUNCTION: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). {ECO:0000250|UniProtKB:Q9Z320}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). {ECO:0000305}.	epithelial cell differentiation [GO:0030855]; hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z320}.
Q7Z3Y9	reviewed	K1C26_HUMAN	Keratin, type I cytoskeletal 26 (Cytokeratin-26) (CK-26) (Keratin-25B) (K25B) (Keratin-26) (K26) (Type I inner root sheath-specific keratin-K25irs2)	KRT26 KRT25B	Homo sapiens (Human)	468		MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). {ECO:0000305}.	epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
Q7Z3Z0	reviewed	K1C25_HUMAN	Keratin, type I cytoskeletal 25 (Cytokeratin-25) (CK-25) (Keratin-25) (K25) (Keratin-25A) (K25A) (Type I inner root sheath-specific keratin-K25irs1)	KRT25 KRT25A	Homo sapiens (Human)	450	FUNCTION: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (PubMed:26902920). {ECO:0000250|UniProtKB:Q8VCW2, ECO:0000269|PubMed:26902920}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). {ECO:0000305}.	cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; hair cycle [GO:0042633]; hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]	protein heterodimerization activity [GO:0046982]; structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; protein heterodimerization activity [GO:0046982]; structural molecule activity [GO:0005198]; cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; hair cycle [GO:0042633]; hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8VCW2}.
Q7Z3Z2	reviewed	RD3_HUMAN	Protein RD3 (Retinal degeneration protein 3)	RD3 C1orf36	Homo sapiens (Human)	195	FUNCTION: Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors (PubMed:29515371, PubMed:21928830, PubMed:21078983, PubMed:27471269, PubMed:30559291). Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors (PubMed:21928830, PubMed:27471269, PubMed:29515371, PubMed:30559291). Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment (PubMed:21078983). Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP (PubMed:29515371). Plays an important role for the survival of rods and cones in the retina (By similarity). {ECO:0000250|UniProtKB:Q8BRE0, ECO:0000269|PubMed:21078983, ECO:0000269|PubMed:21928830, ECO:0000269|PubMed:27471269, ECO:0000269|PubMed:29515371, ECO:0000269|PubMed:30559291}.		negative regulation of guanylate cyclase activity [GO:0031283]; protein transport [GO:0015031]; response to stimulus [GO:0050896]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	cone photoreceptor outer segment [GO:0120199]; cytoplasm [GO:0005737]; endosome [GO:0005768]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; rod photoreceptor outer segment [GO:0120200]		cone photoreceptor outer segment [GO:0120199]; cytoplasm [GO:0005737]; endosome [GO:0005768]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; rod photoreceptor outer segment [GO:0120200]; negative regulation of guanylate cyclase activity [GO:0031283]; protein transport [GO:0015031]; response to stimulus [GO:0050896]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q8BRE0}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8BRE0}. Endosome {ECO:0000250|UniProtKB:Q8BRE0}. Nucleus {ECO:0000269|PubMed:26100624, ECO:0000269|PubMed:29030614}. Cytoplasm {ECO:0000269|PubMed:26100624, ECO:0000269|PubMed:29030614}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:29030614}. Note=Colocalizes with GUCY2E and GUCY2F in rods and cones photoreceptors. Colocalizes with GUK1 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer (By similarity). Strong dot-like perinuclear staining in the epithelial cells (PubMed:29030614). {ECO:0000250|UniProtKB:Q8BRE0, ECO:0000269|PubMed:29030614}.
Q7Z3Z4	reviewed	PIWL4_HUMAN	Piwi-like protein 4	PIWIL4 HIWI2 PIWI	Homo sapiens (Human)	852	FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (By similarity). The piRNA process acts upstream of known mediators of DNA methylation (By similarity). Does not show endonuclease activity (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci (PubMed:17544373). In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities. Plays a role in pancreatic beta cell function and insulin secretion (By similarity). Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway (PubMed:28025795). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of cells proliferation in tumors (PubMed:22483988). {ECO:0000250|UniProtKB:Q8CGT6, ECO:0000269|PubMed:17544373, ECO:0000269|PubMed:22483988, ECO:0000269|PubMed:28025795}.		cell differentiation [GO:0030154]; epithelial structure maintenance [GO:0010669]; meiotic cell cycle [GO:0051321]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposon silencing by heterochromatin formation [GO:0141005]; secondary piRNA processing [GO:0140965]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]; piP-body [GO:0071547]	piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]; piP-body [GO:0071547]; piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521]; cell differentiation [GO:0030154]; epithelial structure maintenance [GO:0010669]; meiotic cell cycle [GO:0051321]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposon silencing by heterochromatin formation [GO:0141005]; secondary piRNA processing [GO:0140965]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25038252, ECO:0000269|PubMed:28025795}. Cytoplasm {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:25038252, ECO:0000269|PubMed:28025795}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. PIWIL2/MILI is required for nuclear localization (By similarity). {ECO:0000250|UniProtKB:Q8CGT6}.
Q7Z401	reviewed	MYCPP_HUMAN	C-myc promoter-binding protein (DENN domain-containing protein 4A)	DENND4A IRLB MYCPBP	Homo sapiens (Human)	1863	FUNCTION: Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}.		regulation of DNA-templated transcription [GO:0006355]; regulation of Rab protein signal transduction [GO:0032483]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]	DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of DNA-templated transcription [GO:0006355]; regulation of Rab protein signal transduction [GO:0032483]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q7Z403	reviewed	TMC6_HUMAN	Transmembrane channel-like protein 6 (Epidermodysplasia verruciformis protein 1) (Protein LAK-4)	TMC6 EVER1 EVIN1	Homo sapiens (Human)	805	FUNCTION: Probable ion channel. {ECO:0000250}.			cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	mechanosensitive monoatomic ion channel activity [GO:0008381]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; mechanosensitive monoatomic ion channel activity [GO:0008381]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12426567}; Multi-pass membrane protein {ECO:0000269|PubMed:12426567}.
Q7Z406	reviewed	MYH14_HUMAN	Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C)	MYH14 KIAA2034 FP17425	Homo sapiens (Human)	1995	FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.		actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; mitochondrion morphogenesis [GO:0070584]; neuronal action potential [GO:0019228]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; skeletal muscle contraction [GO:0003009]; skeletal muscle tissue development [GO:0007519]; vocalization behavior [GO:0071625]	actomyosin [GO:0042641]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; stress fiber [GO:0001725]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]	actomyosin [GO:0042641]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; stress fiber [GO:0001725]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; mitochondrion morphogenesis [GO:0070584]; neuronal action potential [GO:0019228]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; skeletal muscle contraction [GO:0003009]; skeletal muscle tissue development [GO:0007519]; vocalization behavior [GO:0071625]	
Q7Z407	reviewed	CSMD3_HUMAN	CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3)	CSMD3 KIAA1894	Homo sapiens (Human)	3707	FUNCTION: Involved in dendrite development. {ECO:0000250|UniProtKB:Q80T79}.		regulation of dendrite development [GO:0050773]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; regulation of dendrite development [GO:0050773]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80T79}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80T79}.
Q7Z410	reviewed	TMPS9_HUMAN	Transmembrane protease serine 9 (EC 3.4.21.-) (Polyserase-I) (Polyserine protease 1) (Polyserase-1) [Cleaved into: Serase-1; Serase-2; Serase-3]	TMPRSS9	Homo sapiens (Human)	1059	FUNCTION: Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed.		proteolysis [GO:0006508]	plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]	plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12886014}; Single-pass type II membrane protein {ECO:0000269|PubMed:12886014}.
Q7Z412	reviewed	PEX26_HUMAN	Peroxisome assembly protein 26 (Peroxin-26)	PEX26	Homo sapiens (Human)	305	FUNCTION: Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes (PubMed:12717447, PubMed:12851857, PubMed:16854980, PubMed:21362118, PubMed:16763195, PubMed:16257970). PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane (PubMed:12717447, PubMed:12851857, PubMed:16854980, PubMed:21362118, PubMed:16763195, PubMed:16257970). {ECO:0000269|PubMed:12717447, ECO:0000269|PubMed:12851857, ECO:0000269|PubMed:16257970, ECO:0000269|PubMed:16763195, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118}.		protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome membrane [GO:0045046]; protein to membrane docking [GO:0022615]	cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	ATPase binding [GO:0051117]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]	cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; ATPase binding [GO:0051117]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome membrane [GO:0045046]; protein to membrane docking [GO:0022615]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:12717447, ECO:0000269|PubMed:16257970}; Single-pass type II membrane protein {ECO:0000269|PubMed:12717447}.
Q7Z417	reviewed	NUFP2_HUMAN	FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2)	NUFIP2 KIAA1321 PIG1	Homo sapiens (Human)	695	FUNCTION: Binds RNA. {ECO:0000269|PubMed:12837692}.			cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12837692, ECO:0000269|PubMed:26184334}. Cytoplasm {ECO:0000269|PubMed:12837692, ECO:0000269|PubMed:26184334}. Cytoplasm, Stress granule {ECO:0000269|PubMed:26184334}. Note=Distribution is cell cycle-modulated, being cytoplasmic in the G2/M phase and accumulating in nucleus during the G1 phase (PubMed:12837692). {ECO:0000269|PubMed:12837692, ECO:0000269|PubMed:26184334}.
Q7Z418	reviewed	KCNKI_HUMAN	Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel)	KCNK18 TRESK TRIK	Homo sapiens (Human)	384	FUNCTION: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12754259, ECO:0000269|PubMed:15562060}.	MISCELLANEOUS: In contrast to its mouse ortholog, it is not regulated by extracellular protons.	cellular response to pH [GO:0071467]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; stabilization of membrane potential [GO:0030322]	plasma membrane [GO:0005886]	calcium-activated potassium channel activity [GO:0015269]; outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]; calcium-activated potassium channel activity [GO:0015269]; outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]; cellular response to pH [GO:0071467]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20006580}; Multi-pass membrane protein {ECO:0000269|PubMed:20006580}.
Q7Z419	reviewed	R144B_HUMAN	E3 ubiquitin-protein ligase RNF144B (EC 2.3.2.31) (IBR domain-containing protein 2) (RING finger protein 144B) (p53-inducible RING finger protein)	RNF144B IBRDC2 P53RFP	Homo sapiens (Human)	303	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. {ECO:0000269|PubMed:12853982, ECO:0000269|PubMed:20300062}.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; ubiquitin ligase complex [GO:0000151]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; ubiquitin ligase complex [GO:0000151]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:20300062}; Single-pass membrane protein {ECO:0000269|PubMed:20300062}. Cytoplasm {ECO:0000269|PubMed:20300062}. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Q7Z429	reviewed	LFG1_HUMAN	Protein lifeguard 1 (Glutamate [NMDA] receptor-associated protein 1) (NMDA receptor glutamate-binding subunit) (Putative MAPK-activating protein PM02) (Transmembrane BAX inhibitor motif-containing protein 3)	GRINA LFG1 NMDARA1 TMBIM3	Homo sapiens (Human)	371	FUNCTION: Potential apoptotic regulator.		endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	transmembrane transporter binding [GO:0044325]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; transmembrane transporter binding [GO:0044325]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q7Z434	reviewed	MAVS_HUMAN	Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)	MAVS IPS1 KIAA1271 VISA	Homo sapiens (Human)	540	FUNCTION: Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:20127681, PubMed:21170385, PubMed:27992402). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:25636800, PubMed:20127681, PubMed:21170385, PubMed:20628368, PubMed:33110251, PubMed:27736772). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251}.	MISCELLANEOUS: [Isoform 5]: Selectively activates an IFNbeta but not an IL8 promoter. Interacts with RIP1 and FADD and exhibits anti-viral activity against VSV infection. {ECO:0000305}.	activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of IP-10 production [GO:0071660]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein localization to mitochondrion [GO:0070585]; regulation of peroxisome organization [GO:1900063]; signal transduction [GO:0007165]; type I interferon-mediated signaling pathway [GO:0060337]	mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; ubiquitin ligase complex [GO:0000151]	CARD domain binding [GO:0050700]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; protein kinase binding [GO:0019901]; RIG-I binding [GO:0039552]; signaling adaptor activity [GO:0035591]	mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; ubiquitin ligase complex [GO:0000151]; CARD domain binding [GO:0050700]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; protein kinase binding [GO:0019901]; RIG-I binding [GO:0039552]; signaling adaptor activity [GO:0035591]; activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of IP-10 production [GO:0071660]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein localization to mitochondrion [GO:0070585]; regulation of peroxisome organization [GO:1900063]; signal transduction [GO:0007165]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:16125763}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:11780052, ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25135833, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:37311461}. Peroxisome {ECO:0000269|PubMed:20451243}.
Q7Z442	reviewed	PK1L2_HUMAN	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	PKD1L2 KIAA1879 PC1L2	Homo sapiens (Human)	2459	FUNCTION: May function as an ion-channel regulator. May function as a G-protein-coupled receptor. {ECO:0000269|PubMed:15203210}.		detection of mechanical stimulus [GO:0050982]	membrane [GO:0016020]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]	membrane [GO:0016020]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; detection of mechanical stimulus [GO:0050982]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q7Z443	reviewed	PK1L3_HUMAN	Polycystin-1-like protein 3 (Polycystin-1L3) (PC1-like 3 protein) (Polycystic kidney disease protein 1-like 3)	PKD1L3	Homo sapiens (Human)	1732	FUNCTION: Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. {ECO:0000269|PubMed:12782129, ECO:0000269|PubMed:19812697, ECO:0000269|PubMed:23212381}.		cellular response to acidic pH [GO:0071468]; detection of chemical stimulus involved in sensory perception of sour taste [GO:0001581]; detection of mechanical stimulus [GO:0050982]; kidney development [GO:0001822]; monoatomic cation transport [GO:0006812]; sensory perception of sour taste [GO:0050915]	cation channel complex [GO:0034703]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	calcium channel activity [GO:0005262]; carbohydrate binding [GO:0030246]	cation channel complex [GO:0034703]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; calcium channel activity [GO:0005262]; carbohydrate binding [GO:0030246]; cellular response to acidic pH [GO:0071468]; detection of chemical stimulus involved in sensory perception of sour taste [GO:0001581]; detection of mechanical stimulus [GO:0050982]; kidney development [GO:0001822]; monoatomic cation transport [GO:0006812]; sensory perception of sour taste [GO:0050915]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18535624, ECO:0000269|PubMed:20538909, ECO:0000269|PubMed:23212381}; Multi-pass membrane protein {ECO:0000269|PubMed:18535624, ECO:0000269|PubMed:20538909, ECO:0000269|PubMed:23212381}. Note=Interaction with PKD2L1 is required for localization to the cell membrane.
Q7Z449	reviewed	CP2U1_HUMAN	Cytochrome P450 2U1 (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)	CYP2U1	Homo sapiens (Human)	544	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates (PubMed:14660610, PubMed:24563460). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:14660610, PubMed:24563460). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (PubMed:14660610, PubMed:24563460). May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin (PubMed:24563460). {ECO:0000269|PubMed:14660610, ECO:0000269|PubMed:24563460}.		omega-hydroxylase P450 pathway [GO:0097267]; organic acid metabolic process [GO:0006082]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]	arachidonic acid omega-hydroxylase activity [GO:0052869]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; arachidonic acid omega-hydroxylase activity [GO:0052869]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]; omega-hydroxylase P450 pathway [GO:0097267]; organic acid metabolic process [GO:0006082]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14660610}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:14660610}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:23176821}; Multi-pass membrane protein {ECO:0000255}.
Q7Z460	reviewed	CLAP1_HUMAN	CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1)	CLASP1 KIAA0622 MAST1	Homo sapiens (Human)	1538	FUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}.		astral microtubule organization [GO:0030953]; cell division [GO:0051301]; establishment of epithelial cell polarity [GO:0090162]; establishment of mitotic spindle localization [GO:0040001]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of cell polarity [GO:0007163]; exit from mitosis [GO:0010458]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of microtubule polymerization [GO:0031116]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]; vesicle targeting [GO:0006903]	basal cortex [GO:0045180]; cell cortex [GO:0005938]; centrosomal corona [GO:0031592]; centrosome [GO:0005813]; cortical microtubule cytoskeleton [GO:0030981]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; spindle microtubule [GO:0005876]	dystroglycan binding [GO:0002162]; kinetochore binding [GO:0043515]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]	basal cortex [GO:0045180]; cell cortex [GO:0005938]; centrosomal corona [GO:0031592]; centrosome [GO:0005813]; cortical microtubule cytoskeleton [GO:0030981]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; spindle microtubule [GO:0005876]; dystroglycan binding [GO:0002162]; kinetochore binding [GO:0043515]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; astral microtubule organization [GO:0030953]; cell division [GO:0051301]; establishment of epithelial cell polarity [GO:0090162]; establishment of mitotic spindle localization [GO:0040001]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of cell polarity [GO:0007163]; exit from mitosis [GO:0010458]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of microtubule polymerization [GO:0031116]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]; vesicle targeting [GO:0006903]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network {ECO:0000305}. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.
Q7Z465	reviewed	BNIPL_HUMAN	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein	BNIPL	Homo sapiens (Human)	357	FUNCTION: May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. {ECO:0000269|PubMed:12901880}.		apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; regulation of growth rate [GO:0040009]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; regulation of growth rate [GO:0040009]	
Q7Z478	reviewed	DHX29_HUMAN	ATP-dependent RNA helicase DHX29 (EC 3.6.4.13) (DEAH box protein 29) (Nucleic acid helicase DDXx)	DHX29 DDX29	Homo sapiens (Human)	1369	FUNCTION: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. {ECO:0000255|HAMAP-Rule:MF_03068, ECO:0000269|PubMed:19109895, ECO:0000269|PubMed:23706745}.		formation of translation preinitiation complex [GO:0001731]; positive regulation of translational initiation [GO:0045948]; ribosome assembly [GO:0042255]	cytosolic small ribosomal subunit [GO:0022627]; eukaryotic 43S preinitiation complex [GO:0016282]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; helicase activity [GO:0004386]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; translation activator activity [GO:0008494]; translation initiation factor activity [GO:0003743]	cytosolic small ribosomal subunit [GO:0022627]; eukaryotic 43S preinitiation complex [GO:0016282]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; helicase activity [GO:0004386]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; translation activator activity [GO:0008494]; translation initiation factor activity [GO:0003743]; formation of translation preinitiation complex [GO:0001731]; positive regulation of translational initiation [GO:0045948]; ribosome assembly [GO:0042255]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03068}.
Q7Z494	reviewed	NPHP3_HUMAN	Nephrocystin-3	NPHP3 KIAA2000	Homo sapiens (Human)	1330	FUNCTION: Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. {ECO:0000269|PubMed:18371931}.		atrial septum development [GO:0003283]; cilium assembly [GO:0060271]; convergent extension [GO:0060026]; convergent extension involved in gastrulation [GO:0060027]; determination of intestine left/right asymmetry [GO:0071908]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; determination of stomach left/right asymmetry [GO:0071909]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment or maintenance of cell polarity [GO:0007163]; extracellular matrix organization [GO:0030198]; heart looping [GO:0001947]; kidney development [GO:0001822]; kidney morphogenesis [GO:0060993]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; maintenance of animal organ identity [GO:0048496]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; regulation of planar cell polarity pathway involved in neural tube closure [GO:2000167]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; ureter development [GO:0072189]; Wnt signaling pathway [GO:0016055]	ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]		ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; atrial septum development [GO:0003283]; cilium assembly [GO:0060271]; convergent extension [GO:0060026]; convergent extension involved in gastrulation [GO:0060027]; determination of intestine left/right asymmetry [GO:0071908]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; determination of stomach left/right asymmetry [GO:0071909]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment or maintenance of cell polarity [GO:0007163]; extracellular matrix organization [GO:0030198]; heart looping [GO:0001947]; kidney development [GO:0001822]; kidney morphogenesis [GO:0060993]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; maintenance of animal organ identity [GO:0048496]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; regulation of planar cell polarity pathway involved in neural tube closure [GO:2000167]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; ureter development [GO:0072189]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:20462968, ECO:0000269|PubMed:22085962}. Note=Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus.
Q7Z4F1	reviewed	LRP10_HUMAN	Low-density lipoprotein receptor-related protein 10 (LRP-10)	LRP10 MSTP087 SP220 UNQ389/PRO724	Homo sapiens (Human)	713	FUNCTION: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). {ECO:0000250}.		inner ear development [GO:0048839]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]	clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886]	low-density lipoprotein particle receptor activity [GO:0005041]	clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886]; low-density lipoprotein particle receptor activity [GO:0005041]; inner ear development [GO:0048839]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Membrane, coated pit {ECO:0000250}.
Q7Z4G1	reviewed	COMD6_HUMAN	COMM domain-containing protein 6	COMMD6 MSTP076	Homo sapiens (Human)	85	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520, ECO:0000305|PubMed:21778237}.		negative regulation of NF-kappaB transcription factor activity [GO:0032088]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	NF-kappaB binding [GO:0051059]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; NF-kappaB binding [GO:0051059]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16573520, ECO:0000269|PubMed:21778237}. Cytoplasm {ECO:0000269|PubMed:16573520}.
Q7Z4H4	reviewed	ADM2_HUMAN	Protein ADM2 (Intermedin) [Cleaved into: Adrenomedullin-2 (AM2) (Intermedin-long) (IMDL); Intermedin-short (IMDS)]	ADM2 AM2	Homo sapiens (Human)	148	FUNCTION: [Adrenomedullin-2]: May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. {ECO:0000269|PubMed:14615490}.; FUNCTION: [Intermedin-short]: May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. {ECO:0000269|PubMed:14615490}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; feeding behavior [GO:0007631]; negative regulation of blood pressure [GO:0045776]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; positive regulation of heart rate [GO:0010460]; protein phosphorylation [GO:0006468]; regulation of systemic arterial blood pressure [GO:0003073]	extracellular region [GO:0005576]	hormone activity [GO:0005179]; protein-containing complex binding [GO:0044877]	extracellular region [GO:0005576]; hormone activity [GO:0005179]; protein-containing complex binding [GO:0044877]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; feeding behavior [GO:0007631]; negative regulation of blood pressure [GO:0045776]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; positive regulation of heart rate [GO:0010460]; protein phosphorylation [GO:0006468]; regulation of systemic arterial blood pressure [GO:0003073]	SUBCELLULAR LOCATION: Secreted.
Q7Z4H7	reviewed	HAUS6_HUMAN	HAUS augmin-like complex subunit 6	HAUS6 DGT6 FAM29A KIAA1574	Homo sapiens (Human)	955	FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.		cell division [GO:0051301]; centrosome cycle [GO:0007098]; microtubule cytoskeleton organization [GO:0000226]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]	microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; microtubule binding [GO:0008017]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; microtubule cytoskeleton organization [GO:0000226]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18443220, ECO:0000269|PubMed:19029337}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}.
Q7Z4H8	reviewed	PLGT3_HUMAN	Protein O-glucosyltransferase 3 (EC 2.4.1.-) (KDEL motif-containing protein 2) (Protein O-xylosyltransferase POGLUT3) (EC 2.4.2.-)	POGLUT3 KDELC2 UNQ1904/PRO4350	Homo sapiens (Human)	507	FUNCTION: Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1 (PubMed:30127001, PubMed:34411563). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001). {ECO:0000269|PubMed:30127001, ECO:0000269|PubMed:34411563}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	protein O-linked glycosylation via serine [GO:0018242]	endomembrane system [GO:0012505]; endoplasmic reticulum lumen [GO:0005788]	EGF-domain serine glucosyltransferase activity [GO:0140561]; EGF-domain serine xylosyltransferase activity [GO:0140562]; glucosyltransferase activity [GO:0046527]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252]	endomembrane system [GO:0012505]; endoplasmic reticulum lumen [GO:0005788]; EGF-domain serine glucosyltransferase activity [GO:0140561]; EGF-domain serine xylosyltransferase activity [GO:0140562]; glucosyltransferase activity [GO:0046527]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252]; protein O-linked glycosylation via serine [GO:0018242]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q7Z4I7	reviewed	LIMS2_HUMAN	LIM and senescent cell antigen-like-containing domain protein 2 (LIM-like protein 2) (Particularly interesting new Cys-His protein 2) (PINCH-2)	LIMS2 PINCH2	Homo sapiens (Human)	341	FUNCTION: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration. {ECO:0000269|PubMed:12167643}.		cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cholangiocyte proliferation [GO:1990705]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cholangiocyte proliferation [GO:1904055]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural precursor cell proliferation [GO:0061351]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cholangiocyte proliferation [GO:1990705]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cholangiocyte proliferation [GO:1904055]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural precursor cell proliferation [GO:0061351]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cell junction, focal adhesion {ECO:0000269|PubMed:12167643}. Cell membrane {ECO:0000269|PubMed:12167643}; Peripheral membrane protein {ECO:0000269|PubMed:12167643}; Cytoplasmic side {ECO:0000269|PubMed:12167643}.
Q7Z4K8	reviewed	TRI46_HUMAN	Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein)	TRIM46 TRIFIC	Homo sapiens (Human)	759	FUNCTION: Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration. {ECO:0000250|UniProtKB:Q7TNM2}.		anterograde synaptic vesicle transport [GO:0048490]; axonogenesis [GO:0007409]; microtubule bundle formation [GO:0001578]; negative regulation of axon extension [GO:0030517]; neuron migration [GO:0001764]; positive regulation of anterograde dense core granule transport [GO:1901953]; protein localization to axon [GO:0099612]; regulation of protein localization [GO:0032880]	axon cytoplasm [GO:1904115]; axon initial segment [GO:0043194]; cytoskeleton [GO:0005856]; main axon [GO:0044304]; proximal neuron projection [GO:1990769]	zinc ion binding [GO:0008270]	axon cytoplasm [GO:1904115]; axon initial segment [GO:0043194]; cytoskeleton [GO:0005856]; main axon [GO:0044304]; proximal neuron projection [GO:1990769]; zinc ion binding [GO:0008270]; anterograde synaptic vesicle transport [GO:0048490]; axonogenesis [GO:0007409]; microtubule bundle formation [GO:0001578]; negative regulation of axon extension [GO:0030517]; neuron migration [GO:0001764]; positive regulation of anterograde dense core granule transport [GO:1901953]; protein localization to axon [GO:0099612]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000250|UniProtKB:Q7TNM2}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q7TNM2}. Note=Microtubule-associated. Localizes to the proximal part of the axon. {ECO:0000250|UniProtKB:Q7TNM2}.
Q7Z4L5	reviewed	TT21B_HUMAN	Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) (Intraflagellar transport 139 homolog)	TTC21B IFT139 KIAA1992 Nbla10696	Homo sapiens (Human)	1316	FUNCTION: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs (PubMed:27932497). Negatively modulates the SHH signal transduction (By similarity). {ECO:0000250|UniProtKB:Q0HA38, ECO:0000269|PubMed:27932497}.		Bergmann glial cell differentiation [GO:0060020]; cerebellar Purkinje cell differentiation [GO:0021702]; cilium assembly [GO:0060271]; forebrain dorsal/ventral pattern formation [GO:0021798]; intraciliary retrograde transport [GO:0035721]; negative regulation of eating behavior [GO:1903999]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; protein localization to cilium [GO:0061512]; protein localization to non-motile cilium [GO:0097499]; regulation of intraciliary retrograde transport [GO:1905799]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]; smoothened signaling pathway [GO:0007224]; ventricular system development [GO:0021591]	ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intraciliary transport particle A [GO:0030991]	chromatin binding [GO:0003682]	ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intraciliary transport particle A [GO:0030991]; chromatin binding [GO:0003682]; Bergmann glial cell differentiation [GO:0060020]; cerebellar Purkinje cell differentiation [GO:0021702]; cilium assembly [GO:0060271]; forebrain dorsal/ventral pattern formation [GO:0021798]; intraciliary retrograde transport [GO:0035721]; negative regulation of eating behavior [GO:1903999]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; protein localization to cilium [GO:0061512]; protein localization to non-motile cilium [GO:0097499]; regulation of intraciliary retrograde transport [GO:1905799]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]; smoothened signaling pathway [GO:0007224]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q0HA38}.
Q7Z4N2	reviewed	TRPM1_HUMAN	Transient receptor potential cation channel subfamily M member 1 (Long transient receptor potential channel 1) (LTrpC1) (Melastatin-1)	TRPM1 LTRPC1 MLSN MLSN1	Homo sapiens (Human)	1603	FUNCTION: Forms nonselective divalent cation-conducting channels which mediate the influx of Na(2+), Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization (PubMed:19436059, PubMed:21278253). Impermeable to zinc ions (PubMed:21278253). In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions (PubMed:21278253). Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel. {ECO:0000250, ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:19436059, ECO:0000269|PubMed:19878917, ECO:0000269|PubMed:19896109, ECO:0000269|PubMed:21278253}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to light stimulus [GO:0071482]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; monoatomic cation transmembrane transport [GO:0098655]; protein tetramerization [GO:0051262]; visual perception [GO:0007601]	axon [GO:0030424]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]	axon [GO:0030424]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to light stimulus [GO:0071482]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; monoatomic cation transmembrane transport [GO:0098655]; protein tetramerization [GO:0051262]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21278253}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:11535825}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30027108}; Multi-pass membrane protein {ECO:0000269|PubMed:30027108}. Cell projection, axon {ECO:0000250|UniProtKB:Q2TV84}.
Q7Z4N8	reviewed	P4HA3_HUMAN	Prolyl 4-hydroxylase subunit alpha-3 (4-PH alpha-3) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3)	P4HA3 UNQ711/PRO1374	Homo sapiens (Human)	544	FUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:12874193, ECO:0000269|PubMed:14500733}.			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000305}.
Q7Z4P5	reviewed	GDF7_HUMAN	Growth/differentiation factor 7 (GDF-7)	GDF7	Homo sapiens (Human)	450	FUNCTION: May play an active role in the motor area of the primate neocortex. {ECO:0000250}.		activin receptor signaling pathway [GO:0032924]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; branching morphogenesis of an epithelial tube [GO:0048754]; cell fate commitment [GO:0045165]; epithelial cell differentiation [GO:0030855]; forebrain morphogenesis [GO:0048853]; gland morphogenesis [GO:0022612]; midbrain development [GO:0030901]; morphogenesis of an epithelial fold [GO:0060571]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of tendon cell differentiation [GO:2001051]; reproductive structure development [GO:0048608]; roof plate formation [GO:0021509]; spinal cord association neuron differentiation [GO:0021527]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; activin receptor signaling pathway [GO:0032924]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; branching morphogenesis of an epithelial tube [GO:0048754]; cell fate commitment [GO:0045165]; epithelial cell differentiation [GO:0030855]; forebrain morphogenesis [GO:0048853]; gland morphogenesis [GO:0022612]; midbrain development [GO:0030901]; morphogenesis of an epithelial fold [GO:0060571]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of tendon cell differentiation [GO:2001051]; reproductive structure development [GO:0048608]; roof plate formation [GO:0021509]; spinal cord association neuron differentiation [GO:0021527]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q7Z4S6	reviewed	KI21A_HUMAN	Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62)	KIF21A KIAA1708 KIF2	Homo sapiens (Human)	1674	FUNCTION: Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity. {ECO:0000250|UniProtKB:Q9QXL2}.		microtubule-based movement [GO:0007018]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]	ankyrin repeat binding [GO:0071532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; ankyrin repeat binding [GO:0071532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QXL2}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QXL2}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QXL2}. Note=In neurons, localized to axons and dendrites. {ECO:0000250|UniProtKB:Q9QXL2}.
Q7Z4T8	reviewed	GLTL5_HUMAN	Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 (Polypeptide GalNAc transferase 15) (GalNAc-T15) (pp-GaNTase 15) (Protein-UDP acetylgalactosaminyltransferase 15) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15)	GALNTL5 GALNT15	Homo sapiens (Human)	443	FUNCTION: Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region.		spermatid development [GO:0007286]	Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]	metal ion binding [GO:0046872]	Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; metal ion binding [GO:0046872]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Localizes to the juxtanuclear region, possibly the late endosome. Not localized in the Golgi apparatus in round spermatids (By similarity). {ECO:0000250}.
Q7Z4T9	reviewed	CFA91_HUMAN	Cilia- and flagella-associated protein 91 (CFAP91) (AMY-1-associating protein expressed in testis 1) (AAT-1) (MYCBP/AMY-1-associated testis-expressed protein 1) (Protein MAATS1)	CFAP91 AAT1 C3orf15 MAATS1	Homo sapiens (Human)	767	FUNCTION: Involved in sperm flagellum axonemal organization and function (PubMed:12223483, PubMed:32161152). May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity). {ECO:0000250|UniProtKB:A8IH47, ECO:0000269|PubMed:12223483, ECO:0000269|PubMed:32161152}.	MISCELLANEOUS: [Isoform 5]: May be produced by alternative promoter usage. {ECO:0000305}.	axonemal central apparatus assembly [GO:1904158]; cell differentiation [GO:0030154]; cilium movement [GO:0003341]; spermatogenesis [GO:0007283]	axoneme [GO:0005930]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]		axoneme [GO:0005930]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; axonemal central apparatus assembly [GO:1904158]; cell differentiation [GO:0030154]; cilium movement [GO:0003341]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12223483, ECO:0000269|PubMed:15863901}. Cytoplasm {ECO:0000269|PubMed:12223483, ECO:0000269|PubMed:15863901}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A8IH47}. Note=Localized in the neck of the sperm.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm {ECO:0000269|PubMed:15863901}.
Q7Z4V0	reviewed	ZN438_HUMAN	Zinc finger protein 438	ZNF438	Homo sapiens (Human)	828	FUNCTION: Isoform 1 acts as a transcriptional repressor.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17669267}.
Q7Z4V5	reviewed	HDGR2_HUMAN	Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	Homo sapiens (Human)	671	FUNCTION: Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}.		chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; muscle cell differentiation [GO:0042692]; muscle organ development [GO:0007517]; positive regulation of cell growth [GO:0030307]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; skeletal muscle tissue regeneration [GO:0043403]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	H3K27me3 modified histone binding [GO:0061628]; H3K9me3 modified histone binding [GO:0062072]; histone reader activity [GO:0140566]; methylated histone binding [GO:0035064]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; H3K27me3 modified histone binding [GO:0061628]; H3K9me3 modified histone binding [GO:0062072]; histone reader activity [GO:0140566]; methylated histone binding [GO:0035064]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; muscle cell differentiation [GO:0042692]; muscle organ development [GO:0007517]; positive regulation of cell growth [GO:0030307]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; skeletal muscle tissue regeneration [GO:0043403]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26721387}. Cytoplasm {ECO:0000250|UniProtKB:Q925G1}.
Q7Z4W1	reviewed	DCXR_HUMAN	L-xylulose reductase (XR) (EC 1.1.1.10) (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Short chain dehydrogenase/reductase family 20C member 1) (Sperm surface protein P34H)	DCXR SDR20C1	Homo sapiens (Human)	244	FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.		D-xylose metabolic process [GO:0042732]; glucose metabolic process [GO:0006006]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; NADP metabolic process [GO:0006739]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; xylulose metabolic process [GO:0005997]	brush border [GO:0005903]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	carbonyl reductase (NADPH) activity [GO:0004090]; identical protein binding [GO:0042802]; L-xylulose reductase (NADP+) activity [GO:0050038]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]	brush border [GO:0005903]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; carbonyl reductase (NADPH) activity [GO:0004090]; identical protein binding [GO:0042802]; L-xylulose reductase (NADP+) activity [GO:0050038]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; D-xylose metabolic process [GO:0042732]; glucose metabolic process [GO:0006006]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; NADP metabolic process [GO:0006739]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; xylulose metabolic process [GO:0005997]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Probably recruited to membranes via an interaction with phosphatidylinositol. {ECO:0000250}.
Q7Z4W3	reviewed	KR193_HUMAN	Keratin-associated protein 19-3 (GTHRP) (Glycine/tyrosine-rich protein)	KRTAP19-3 KAP19.3	Homo sapiens (Human)	81	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q7Z569	reviewed	BRAP_HUMAN	BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63)	BRAP RNF52	Homo sapiens (Human)	592	FUNCTION: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}.		MAPK cascade [GO:0000165]; negative regulation of signal transduction [GO:0009968]; protein ubiquitination [GO:0016567]; Ras protein signal transduction [GO:0007265]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; ubiquitin ligase complex [GO:0000151]	identical protein binding [GO:0042802]; nuclear localization sequence binding [GO:0008139]; nucleic acid binding [GO:0003676]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; ubiquitin ligase complex [GO:0000151]; identical protein binding [GO:0042802]; nuclear localization sequence binding [GO:0008139]; nucleic acid binding [GO:0003676]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; MAPK cascade [GO:0000165]; negative regulation of signal transduction [GO:0009968]; protein ubiquitination [GO:0016567]; Ras protein signal transduction [GO:0007265]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9497340}.
Q7Z570	reviewed	Z804A_HUMAN	Zinc finger protein 804A	ZNF804A C2orf10	Homo sapiens (Human)	1209			positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; regulation of neuron projection development [GO:0010975]	cytoplasm [GO:0005737]; dendritic microtubule [GO:1901588]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; dendritic microtubule [GO:1901588]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; metal ion binding [GO:0046872]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; regulation of neuron projection development [GO:0010975]	
Q7Z589	reviewed	EMSY_HUMAN	BRCA2-interacting transcriptional repressor EMSY	EMSY C11orf30 GL002	Homo sapiens (Human)	1322	FUNCTION: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}.	MISCELLANEOUS: Defects in EMSY may be a cause of sporadic breast cancer and higher-grade ovarian cancers. Overexpressed through amplification almost exclusively in sporadic breast cancer (13%) and higher-grade ovarian cancer (17%). Amplification is associated with worse survival, particularly in node-negative breast cancer, suggesting that it may be of prognostic value.; MISCELLANEOUS: Was named EMSY by PubMed:14651845 because the protein sequence contains the word 'SISTER', after the first author's sister, who is a breast cancer nurse.	chromatin organization [GO:0006325]; DNA repair [GO:0006281]; regulation of DNA-templated transcription [GO:0006355]	nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]	nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; chromatin organization [GO:0006325]; DNA repair [GO:0006281]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14651845}. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.
Q7Z591	reviewed	AKNA_HUMAN	Microtubule organization protein AKNA (AT-hook-containing transcription factor)	AKNA KIAA1968	Homo sapiens (Human)	1439	FUNCTION: Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}.		delamination [GO:0060232]; epithelial to mesenchymal transition [GO:0001837]; neuroblast delamination [GO:0060234]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of inflammatory response [GO:0050727]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; delamination [GO:0060232]; epithelial to mesenchymal transition [GO:0001837]; neuroblast delamination [GO:0060234]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q80VW7}. Nucleus {ECO:0000269|PubMed:11268217}. Note=Localizes to the distal part of the subdistal appendages of the mother centriole in interphase. Also found at the proximal ends of centrioles and along microtubules. The centrosomal localization is dependent on centrioles. Dissociates from centrosomes during M-phase without proteolytic degradation and reassembles at the centrosomes during late telophase and early G1 phase. Dissociation and reassembly is regulated by phosphorylation. {ECO:0000250|UniProtKB:Q80VW7}.
Q7Z5A7	reviewed	TAFA5_HUMAN	Chemokine-like protein TAFA-5	TAFA5 FAM19A5 UNQ5208/PRO34524	Homo sapiens (Human)	132	FUNCTION: Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity). {ECO:0000250|UniProtKB:M0R7X9, ECO:0000250|UniProtKB:Q91WE9}.	MISCELLANEOUS: [Isoform 2]: Contains a predicted signal peptide at positions 1-25. {ECO:0000305}.	G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular wound healing [GO:0061044]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; G protein-coupled receptor binding [GO:0001664]; receptor ligand activity [GO:0048018]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; G protein-coupled receptor binding [GO:0001664]; receptor ligand activity [GO:0048018]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular wound healing [GO:0061044]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15028294, ECO:0000269|PubMed:29453251}.
Q7Z5B4	reviewed	RIC3_HUMAN	Protein RIC-3 (Resistant to inhibitor of cholinesterase 3)	RIC3 UNQ720/PRO1385	Homo sapiens (Human)	369	FUNCTION: Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors (PubMed:12821669, PubMed:15504725, PubMed:16120769, PubMed:18691158, PubMed:32204458). May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. {ECO:0000269|PubMed:12821669, ECO:0000269|PubMed:15504725, ECO:0000269|PubMed:15809299, ECO:0000269|PubMed:15927954, ECO:0000269|PubMed:16120769, ECO:0000269|PubMed:17609200, ECO:0000269|PubMed:18691158, ECO:0000269|PubMed:32204458}.		positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to cell surface [GO:0034394]; protein-containing complex assembly [GO:0065003]; synaptic transmission, cholinergic [GO:0007271]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; synapse [GO:0045202]	acetylcholine receptor binding [GO:0033130]; protein folding chaperone [GO:0044183]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; synapse [GO:0045202]; acetylcholine receptor binding [GO:0033130]; protein folding chaperone [GO:0044183]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to cell surface [GO:0034394]; protein-containing complex assembly [GO:0065003]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Q7Z5G4	reviewed	GOGA7_HUMAN	Golgin subfamily A member 7 (Golgi complex-associated protein of 16 kDa)	GOLGA7 GCP16 HDCKB03P HSPC041	Homo sapiens (Human)	137	FUNCTION: May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. {ECO:0000269|PubMed:14522980, ECO:0000269|PubMed:16000296}.		Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein stabilization [GO:0050821]; protein targeting to membrane [GO:0006612]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; palmitoyltransferase complex [GO:0002178]; tertiary granule lumen [GO:1904724]		extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; palmitoyltransferase complex [GO:0002178]; tertiary granule lumen [GO:1904724]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein stabilization [GO:0050821]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:14522980, ECO:0000269|PubMed:16000296}; Lipid-anchor {ECO:0000269|PubMed:14522980, ECO:0000269|PubMed:16000296}.
Q7Z5H3	reviewed	RHG22_HUMAN	Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22)	ARHGAP22 RHOGAP2	Homo sapiens (Human)	698	FUNCTION: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}.		angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; regulation of postsynapse organization [GO:0099175]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; GTPase activator activity [GO:0005096]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; regulation of postsynapse organization [GO:0099175]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity). {ECO:0000250}.
Q7Z5J1	reviewed	DHI1L_HUMAN	Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 3) (11-DH3) (11-beta-HSD3) (Short chain dehydrogenase/reductase family 26C member 2) (Short-chain dehydrogenase/reductase 10)	HSD11B1L HSD3 SCDR10 SDR26C2	Homo sapiens (Human)	315				extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; oxidoreductase activity [GO:0016491]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q7Z5J4	reviewed	RAI1_HUMAN	Retinoic acid-induced protein 1	RAI1 KIAA1820	Homo sapiens (Human)	1906	FUNCTION: Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.		circadian regulation of gene expression [GO:0032922]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; circadian regulation of gene expression [GO:0032922]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=In neurons, localized to neurites. {ECO:0000250}.
Q7Z5K2	reviewed	WAPL_HUMAN	Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor)	WAPL FOE KIAA0261 WAPAL	Homo sapiens (Human)	1190	FUNCTION: Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}.		cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA replication [GO:0008156]; negative regulation of sister chromatid cohesion [GO:0045875]; protein localization to chromatin [GO:0071168]; regulation of cohesin loading [GO:0071922]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP-dependent protein-DNA unloader activity [GO:0140083]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP-dependent protein-DNA unloader activity [GO:0140083]; cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA replication [GO:0008156]; negative regulation of sister chromatid cohesion [GO:0045875]; protein localization to chromatin [GO:0071168]; regulation of cohesin loading [GO:0071922]	SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.; SUBCELLULAR LOCATION: Nucleus. Chromosome {ECO:0000269|PubMed:26299517}. Cytoplasm. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.
Q7Z5L2	reviewed	R3HCL_HUMAN	Coiled-coil domain-containing protein R3HCC1L (Growth inhibition and differentiation-related protein 88) (Putative mitochondrial space protein 32.1) (R3H and coiled-coil domain-containing protein 1-like)	R3HCC1L C10orf28 GIDRP88	Homo sapiens (Human)	792							
Q7Z5L7	reviewed	PODN_HUMAN	Podocan	PODN SLRR5A UNQ293/PRO332	Homo sapiens (Human)	613	FUNCTION: Negatively regulates cell proliferation and cell migration. {ECO:0000269|PubMed:15063725}.	MISCELLANEOUS: [Isoform 2]: No signal peptide. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: No signal peptide. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: No signal peptide. {ECO:0000305}.	negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]	collagen binding [GO:0005518]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; collagen binding [GO:0005518]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted, extracellular space, extracellular matrix.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.
Q7Z5L9	reviewed	I2BP2_HUMAN	Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)	IRF2BP2	Homo sapiens (Human)	587	FUNCTION: Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}.		immature B cell differentiation [GO:0002327]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; immature B cell differentiation [GO:0002327]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q7Z5N4	reviewed	SDK1_HUMAN	Protein sidekick-1	SDK1	Homo sapiens (Human)	2213	FUNCTION: Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q8AV58}.	MISCELLANEOUS: Dysregulation of this protein may play an important role in podocyte dysfunction in HIV-associated nephropathy. {ECO:0000269|PubMed:15213259}.	behavioral response to cocaine [GO:0048148]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of dendritic spine development [GO:0060998]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416]	plasma membrane [GO:0005886]; synapse [GO:0045202]	identical protein binding [GO:0042802]	plasma membrane [GO:0005886]; synapse [GO:0045202]; identical protein binding [GO:0042802]; behavioral response to cocaine [GO:0048148]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of dendritic spine development [GO:0060998]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8AV58}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8AV58}. Synapse {ECO:0000250|UniProtKB:Q8AV58}.
Q7Z5P4	reviewed	DHB13_HUMAN	17-beta-hydroxysteroid dehydrogenase 13 (17-beta-HSD 13) (EC 1.1.1.-) (EC 1.1.1.62) (Hepatic retinol/retinal dehydrogenase) (EC 1.1.1.105) (Short chain dehydrogenase/reductase family 16C member 3) (Short-chain dehydrogenase/reductase 9)	HSD17B13 SCDR9 SDR16C3 HMFN0376 UNQ497/PRO1014	Homo sapiens (Human)	300	FUNCTION: Plays a pivotal role in hepatic lipid metabolism (PubMed:29562163). In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4 (PubMed:29562163, PubMed:30415504, PubMed:32973038). {ECO:0000269|PubMed:29562163, ECO:0000269|PubMed:30415504, ECO:0000269|PubMed:32973038}.; FUNCTION: [Isoform 2]: Has retinol/retinal dehydrogenase activity in vitro. {ECO:0000269|PubMed:30415504, ECO:0000269|PubMed:32973038}.; FUNCTION: [Isoform 1]: Does not have retinol/retinal dehydrogenase activity in vitro. {ECO:0000269|PubMed:30415504}.		lipid metabolic process [GO:0006629]; positive regulation of lipid biosynthetic process [GO:0046889]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]	estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; NAD-retinol dehydrogenase activity [GO:0004745]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity [GO:0016229]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; NAD-retinol dehydrogenase activity [GO:0004745]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity [GO:0016229]; lipid metabolic process [GO:0006629]; positive regulation of lipid biosynthetic process [GO:0046889]	SUBCELLULAR LOCATION: [Isoform 2]: Lipid droplet {ECO:0000269|PubMed:29562163, ECO:0000269|PubMed:30415504, ECO:0000269|PubMed:32973038}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VCR2}. Note=Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation. {ECO:0000250|UniProtKB:Q8VCR2}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:30415504}. Note=Does not localize to lipid droplets. {ECO:0000269|PubMed:30415504}.
Q7Z5P9	reviewed	MUC19_HUMAN	Mucin-19 (MUC-19)	MUC19	Homo sapiens (Human)	8384	FUNCTION: May function in ocular mucus homeostasis. {ECO:0000269|PubMed:18184611}.			extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q7Z5Q1	reviewed	CPEB2_HUMAN	Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (hCPEB-2)	CPEB2	Homo sapiens (Human)	589	FUNCTION: May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0, ECO:0000269|PubMed:26398195}.		cellular response to arsenic-containing substance [GO:0071243]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of cytoplasmic translational elongation [GO:1900248]; negative regulation of GTPase activity [GO:0034260]	cytoplasm [GO:0005737]; messenger ribonucleoprotein complex [GO:1990124]; neuron projection [GO:0043005]; nucleus [GO:0005634]; synapse [GO:0045202]	GTPase inhibitor activity [GO:0005095]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; messenger ribonucleoprotein complex [GO:1990124]; neuron projection [GO:0043005]; nucleus [GO:0005634]; synapse [GO:0045202]; GTPase inhibitor activity [GO:0005095]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of cytoplasmic translational elongation [GO:1900248]; negative regulation of GTPase activity [GO:0034260]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q812E0}.
Q7Z5Q5	reviewed	DPOLN_HUMAN	DNA polymerase nu (EC 2.7.7.7)	POLN	Homo sapiens (Human)	900	FUNCTION: DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template (PubMed:16787914, PubMed:17118716). Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity (PubMed:16787914). Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence (PubMed:25775266). May play a role in TLS during interstrand cross-link (ICL) repair (PubMed:19908865). May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agents (PubMed:20102227). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904). {ECO:0000269|PubMed:16787914, ECO:0000269|PubMed:17118716, ECO:0000269|PubMed:19908865, ECO:0000269|PubMed:19995904, ECO:0000269|PubMed:20102227, ECO:0000269|PubMed:25775266}.		DNA-templated DNA replication [GO:0006261]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; translesion synthesis [GO:0019985]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin binding [GO:0030332]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin binding [GO:0030332]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; DNA-templated DNA replication [GO:0006261]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; translesion synthesis [GO:0019985]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12794064}.
Q7Z5R6	reviewed	AB1IP_HUMAN	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1)	APBB1IP PREL1 RARP1 RIAM	Homo sapiens (Human)	666	FUNCTION: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.		positive regulation of cell adhesion [GO:0045785]; signal transduction [GO:0007165]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; positive regulation of cell adhesion [GO:0045785]; signal transduction [GO:0007165]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity). {ECO:0000250}.
Q7Z5V6	reviewed	SAXO4_HUMAN	Stabilizer of axonemal microtubules 4 (Protein phosphatase 1 regulatory subunit 32)	SAXO4 C11orf66 PPP1R32	Homo sapiens (Human)	425				ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]	phosphatase binding [GO:0019902]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; phosphatase binding [GO:0019902]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q66HR9}. Cytoplasm {ECO:0000250|UniProtKB:Q66HR9}. Note=Localized to the cilia of polarized ependymal cells during development and at the adult stage. Preferentially locates between the peripheral microtubules of the axoneme and the ciliary membrane. {ECO:0000250|UniProtKB:Q66HR9}.
Q7Z5W3	reviewed	BN3D2_HUMAN	RNA 5'-monophosphate methyltransferase (EC 2.1.1.-) (BCDIN3 domain-containing protein)	BCDIN3D	Homo sapiens (Human)	292	FUNCTION: O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1 (PubMed:28119416, PubMed:31329584, PubMed:31919512). Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing (PubMed:23063121, PubMed:28119416). The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1 (PubMed:23063121). Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145 (PubMed:23063121, PubMed:28119416). {ECO:0000269|PubMed:23063121, ECO:0000269|PubMed:28119416, ECO:0000269|PubMed:31329584, ECO:0000269|PubMed:31919512}.		miRNA metabolic process [GO:0010586]; negative regulation of pre-miRNA processing [GO:2000632]; pre-miRNA processing [GO:0031054]; RNA methylation [GO:0001510]; tRNA methylation [GO:0030488]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	O-methyltransferase activity [GO:0008171]; pre-miRNA binding [GO:0070883]; RNA methyltransferase activity [GO:0008173]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; small RNA 2'-O-methyltransferase activity [GO:0090486]; tRNA methyltransferase activity [GO:0008175]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; O-methyltransferase activity [GO:0008171]; pre-miRNA binding [GO:0070883]; RNA methyltransferase activity [GO:0008173]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; small RNA 2'-O-methyltransferase activity [GO:0090486]; tRNA methyltransferase activity [GO:0008175]; miRNA metabolic process [GO:0010586]; negative regulation of pre-miRNA processing [GO:2000632]; pre-miRNA processing [GO:0031054]; RNA methylation [GO:0001510]; tRNA methylation [GO:0030488]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23063121}.
Q7Z5Y6	reviewed	BMP8A_HUMAN	Bone morphogenetic protein 8A (BMP-8A)	BMP8A	Homo sapiens (Human)	402	FUNCTION: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT. {ECO:0000250, ECO:0000269|PubMed:22579288}.; FUNCTION: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance (PubMed:22579288, PubMed:31940275). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:31940275). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway (PubMed:31940275). {ECO:0000269|PubMed:22579288, ECO:0000269|PubMed:31940275}.		cartilage development [GO:0051216]; cell differentiation [GO:0030154]; diet induced thermogenesis [GO:0002024]; energy homeostasis [GO:0097009]; negative regulation of insulin secretion [GO:0046676]; ossification [GO:0001503]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; diet induced thermogenesis [GO:0002024]; energy homeostasis [GO:0097009]; negative regulation of insulin secretion [GO:0046676]; ossification [GO:0001503]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q7Z602	reviewed	GP141_HUMAN	Probable G-protein coupled receptor 141 (G-protein coupled receptor PGR13)	GPR141 PGR13	Homo sapiens (Human)	305	FUNCTION: Orphan receptor.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; oxysterol binding [GO:0008142]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; oxysterol binding [GO:0008142]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q7Z614	reviewed	SNX20_HUMAN	Sorting nexin-20 (Selectin ligand-interactor cytoplasmic 1) (SLIC-1)	SNX20 SLIC1	Homo sapiens (Human)	316	FUNCTION: May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion. {ECO:0000305|PubMed:18196517}.		protein transport [GO:0015031]	early endosome membrane [GO:0031901]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	early endosome membrane [GO:0031901]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:18196517}; Peripheral membrane protein {ECO:0000269|PubMed:18196517}; Cytoplasmic side {ECO:0000269|PubMed:18196517}. Cell membrane {ECO:0000269|PubMed:18196517}. Cytoplasm {ECO:0000269|PubMed:18196517}. Nucleus {ECO:0000269|PubMed:18196517}.
Q7Z624	reviewed	CMKMT_HUMAN	Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60)	CAMKMT C2orf34 CLNMT	Homo sapiens (Human)	323	FUNCTION: Catalyzes the trimethylation of 'Lys-116' in calmodulin. {ECO:0000269|PubMed:20975703}.		methylation [GO:0032259]; mitochondrion organization [GO:0007005]; regulation of rhodopsin mediated signaling pathway [GO:0022400]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	calmodulin-lysine N-methyltransferase activity [GO:0018025]; heat shock protein binding [GO:0031072]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; calmodulin-lysine N-methyltransferase activity [GO:0018025]; heat shock protein binding [GO:0031072]; methylation [GO:0032259]; mitochondrion organization [GO:0007005]; regulation of rhodopsin mediated signaling pathway [GO:0022400]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:23285036}. Nucleus {ECO:0000269|PubMed:23285036}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus {ECO:0000269|PubMed:23285036}.
Q7Z628	reviewed	ARHG8_HUMAN	Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8)	NET1 ARHGEF8	Homo sapiens (Human)	596	FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}.		cellular response to hydrogen peroxide [GO:0070301]; cellular response to ionizing radiation [GO:0071479]; intracellular signal transduction [GO:0035556]; myoblast migration [GO:0051451]; positive regulation of apoptotic process [GO:0043065]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell growth [GO:0001558]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]; nucleus [GO:0005634]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; nucleus [GO:0005634]; guanyl-nucleotide exchange factor activity [GO:0005085]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to ionizing radiation [GO:0071479]; intracellular signal transduction [GO:0035556]; myoblast migration [GO:0051451]; positive regulation of apoptotic process [GO:0043065]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell growth [GO:0001558]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q7Z698	reviewed	SPRE2_HUMAN	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)	SPRED2	Homo sapiens (Human)	418	FUNCTION: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S7, ECO:0000269|PubMed:15683364, ECO:0000269|PubMed:34626534}.		negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of protein deacetylation [GO:0090311]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]	protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; stem cell factor receptor binding [GO:0005173]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; stem cell factor receptor binding [GO:0005173]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of protein deacetylation [GO:0090311]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:34626534}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q924S7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q924S7}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:15580519}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:15580519}. Note=Detected in the cytoplasm of the stratum spinosum cells, where it is associated with cytoplasmic vesicles that are supposed to be secretory granules. {ECO:0000269|PubMed:15580519}.
Q7Z699	reviewed	SPRE1_HUMAN	Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)	SPRED1	Homo sapiens (Human)	444	FUNCTION: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S8, ECO:0000269|PubMed:18216281}.		negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of MAPK cascade [GO:0043408]; regulation of protein deacetylation [GO:0090311]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]	caveola [GO:0005901]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; stem cell factor receptor binding [GO:0005173]	caveola [GO:0005901]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; stem cell factor receptor binding [GO:0005173]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of MAPK cascade [GO:0043408]; regulation of protein deacetylation [GO:0090311]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16115197}; Peripheral membrane protein {ECO:0000269|PubMed:16115197}. Membrane, caveola {ECO:0000269|PubMed:16115197}; Peripheral membrane protein {ECO:0000269|PubMed:16115197}. Nucleus {ECO:0000269|PubMed:16115197}. Note=Localized in cholesterol-rich membrane raft/caveola fractions.
Q7Z6A9	reviewed	BTLA_HUMAN	B- and T-lymphocyte attenuator (B- and T-lymphocyte-associated protein) (CD antigen CD272)	BTLA	Homo sapiens (Human)	289	FUNCTION: Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044). {ECO:0000269|PubMed:12796776, ECO:0000269|PubMed:14652006, ECO:0000269|PubMed:15568026, ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:19915044}.		adaptive immune response [GO:0002250]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]	plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; adaptive immune response [GO:0002250]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12796776}; Single-pass type I membrane protein {ECO:0000305}.
Q7Z6B0	reviewed	CCD91_HUMAN	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein)	CCDC91 GGABP HSD8	Homo sapiens (Human)	441	FUNCTION: Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. {ECO:0000269|PubMed:17596511}.	MISCELLANEOUS: [Isoform 1]: Binds GGAs.; MISCELLANEOUS: [Isoform 2]: Does not bind GGAs. {ECO:0000305}.	Golgi to lysosome transport [GO:0090160]; protein transport [GO:0015031]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]		cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]; Golgi to lysosome transport [GO:0090160]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12808037}; Peripheral membrane protein {ECO:0000269|PubMed:12808037}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12808037}; Peripheral membrane protein {ECO:0000269|PubMed:12808037}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:17596511}. Note=Colocalizes with GGA1, GGA2 and GGA3. {ECO:0000269|PubMed:12808037, ECO:0000269|PubMed:17596511}.
Q7Z6B7	reviewed	SRGP1_HUMAN	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13)	SRGAP1 ARHGAP13 KIAA1304	Homo sapiens (Human)	1085	FUNCTION: GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}.		negative regulation of cell migration [GO:0030336]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; negative regulation of cell migration [GO:0030336]; signal transduction [GO:0007165]	
Q7Z6E9	reviewed	RBBP6_HUMAN	E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)	RBBP6 P2PR PACT RBQ1 My038	Homo sapiens (Human)	1792	FUNCTION: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}.		DNA damage response [GO:0006974]; DNA replication [GO:0006260]; embryonic organ development [GO:0048568]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; protein ubiquitination [GO:0016567]; regulation of DNA replication [GO:0006275]; somite development [GO:0061053]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromosome [GO:0005694]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; DNA damage response [GO:0006974]; DNA replication [GO:0006260]; embryonic organ development [GO:0048568]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; protein ubiquitination [GO:0016567]; regulation of DNA replication [GO:0006275]; somite development [GO:0061053]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.
Q7Z6G3	reviewed	NECA2_HUMAN	N-terminal EF-hand calcium-binding protein 2 (EF-hand calcium-binding protein 2) (Neuronal calcium-binding protein 2) (Synaptotagmin-interacting protein 2) (Stip-2)	NECAB2 EFCBP2	Homo sapiens (Human)	386	FUNCTION: May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. {ECO:0000305|PubMed:17689978, ECO:0000305|PubMed:19694902}.		negative regulation of G protein-coupled receptor internalization [GO:1904021]; positive regulation of adenosine receptor signaling pathway [GO:0060168]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glutamate receptor signaling pathway [GO:1900451]; positive regulation of protein localization to membrane [GO:1905477]; regulation of amyloid precursor protein biosynthetic process [GO:0042984]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; plasma membrane [GO:0005886]	A2A adenosine receptor binding [GO:0031687]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; type 5 metabotropic glutamate receptor binding [GO:0031802]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; A2A adenosine receptor binding [GO:0031687]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; type 5 metabotropic glutamate receptor binding [GO:0031802]; negative regulation of G protein-coupled receptor internalization [GO:1904021]; positive regulation of adenosine receptor signaling pathway [GO:0060168]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glutamate receptor signaling pathway [GO:1900451]; positive regulation of protein localization to membrane [GO:1905477]; regulation of amyloid precursor protein biosynthetic process [GO:0042984]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:F1LQY6, ECO:0000250|UniProtKB:Q91ZP9}. Cell projection, dendrite {ECO:0000250|UniProtKB:F1LQY6}. Cell projection, axon {ECO:0000250|UniProtKB:F1LQY6}. Cell membrane {ECO:0000269|PubMed:17689978, ECO:0000269|PubMed:19694902}. Note=Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (PubMed:17689978, PubMed:19694902). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity). {ECO:0000250|UniProtKB:F1LQY6, ECO:0000269|PubMed:17689978, ECO:0000269|PubMed:19694902, ECO:0000269|PubMed:26843217}.
Q7Z6G8	reviewed	ANS1B_HUMAN	Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1)	ANKS1B	Homo sapiens (Human)	1248	FUNCTION: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}.; FUNCTION: Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.		ephrin receptor signaling pathway [GO:0048013]	Cajal body [GO:0015030]; centrosome [GO:0005813]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	ephrin receptor binding [GO:0046875]	Cajal body [GO:0015030]; centrosome [GO:0005813]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ephrin receptor binding [GO:0046875]; ephrin receptor signaling pathway [GO:0048013]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15004329, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129, ECO:0000269|PubMed:19666031}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. Note=The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus. Note=The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; SUBCELLULAR LOCATION: [Isoform 6]: Nucleus.
Q7Z6I5	reviewed	SPT12_HUMAN	Spermatogenesis-associated protein 12 (Spermatogenesis-related protein 5)	SPATA12 SRG5	Homo sapiens (Human)	190							
Q7Z6I6	reviewed	RHG30_HUMAN	Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30)	ARHGAP30	Homo sapiens (Human)	1101	FUNCTION: GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}.		regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]	GTPase activator activity [GO:0005096]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; GTPase activator activity [GO:0005096]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:21565175}.
Q7Z6J0	reviewed	SH3R1_HUMAN	E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2)	SH3RF1 KIAA1494 POSH POSH1 RNF142 SH3MD2	Homo sapiens (Human)	888	FUNCTION: Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. {ECO:0000269|PubMed:15659549}.		negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neuron migration [GO:0001764]; positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043370]; regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000564]; response to aldosterone [GO:1904044]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]	MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neuron migration [GO:0001764]; positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043370]; regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000564]; response to aldosterone [GO:1904044]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q71F54}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q69ZI1}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:17420289}. Note=Colocalizes, with AKT2, in lamellipodia (By similarity). Colocalizes, with HERP1, in trans-Golgi network. {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:17420289}.
Q7Z6J4	reviewed	FGD2_HUMAN	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)	FGD2 ZFYVE4	Homo sapiens (Human)	655	FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 4]: May be due to an intron retention. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Early endosome {ECO:0000250}. Early endosome membrane {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. {ECO:0000250}.
Q7Z6J6	reviewed	FRMD5_HUMAN	FERM domain-containing protein 5	FRMD5	Homo sapiens (Human)	570	FUNCTION: May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).		actomyosin structure organization [GO:0031032]; negative regulation of cell motility [GO:2000146]; positive regulation of cell adhesion [GO:0045785]; regulation of cell migration [GO:0030334]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; membrane [GO:0016020]	cytoskeletal protein binding [GO:0008092]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; cytoskeletal protein binding [GO:0008092]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]; actomyosin structure organization [GO:0031032]; negative regulation of cell motility [GO:2000146]; positive regulation of cell adhesion [GO:0045785]; regulation of cell migration [GO:0030334]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:22846708}.
Q7Z6J8	reviewed	UBE3D_HUMAN	E3 ubiquitin-protein ligase E3D (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase E3D) (UbcH10-binding protein with a HECT-like domain) (Ubiquitin-conjugating enzyme E2C-binding protein)	UBE3D C6orf157 H10BH UBE2CBP	Homo sapiens (Human)	389	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. {ECO:0000269|PubMed:15749827}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]	cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	cyclin binding [GO:0030332]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]	cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; cyclin binding [GO:0030332]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q7Z6J9	reviewed	SEN54_HUMAN	tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54)	TSEN54 SEN54	Homo sapiens (Human)	526	FUNCTION: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}.		mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]; tRNA-type intron splice site recognition and cleavage [GO:0000379]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214]		nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214]; mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]; tRNA-type intron splice site recognition and cleavage [GO:0000379]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Note=May be transiently localized in the nucleolus. {ECO:0000305}.
Q7Z6K1	reviewed	THAP5_HUMAN	THAP domain-containing protein 5	THAP5	Homo sapiens (Human)	395	FUNCTION: Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560). {ECO:0000269|PubMed:21110952, ECO:0000305|PubMed:19502560}.		cell cycle [GO:0007049]; negative regulation of cell cycle [GO:0045786]; negative regulation of transcription by RNA polymerase II [GO:0000122]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protease binding [GO:0002020]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; cell cycle [GO:0007049]; negative regulation of cell cycle [GO:0045786]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19502560, ECO:0000269|PubMed:21110952}.
Q7Z6K5	reviewed	ARPIN_HUMAN	Arpin (Arp2/3 inhibition protein)	ARPIN C15orf38	Homo sapiens (Human)	226	FUNCTION: Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence. {ECO:0000269|PubMed:24132237}.	MISCELLANEOUS: [Isoform C15orf38-AP3S2]: Based on a naturally occurring readthrough transcript which produces a C15orf38-AP3S2 fusion protein. {ECO:0000305}.	directional locomotion [GO:0033058]; negative regulation of actin nucleation [GO:0051126]; negative regulation of cell migration [GO:0030336]; negative regulation of lamellipodium morphogenesis [GO:2000393]	lamellipodium [GO:0030027]		lamellipodium [GO:0030027]; directional locomotion [GO:0033058]; negative regulation of actin nucleation [GO:0051126]; negative regulation of cell migration [GO:0030336]; negative regulation of lamellipodium morphogenesis [GO:2000393]	SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000250}. Note=Colocalized with the WAVE complex at lamelliupodium tip. {ECO:0000250}.
Q7Z6L0	reviewed	PRRT2_HUMAN	Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3)	PRRT2	Homo sapiens (Human)	340	FUNCTION: As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation. {ECO:0000250|UniProtKB:E9PUL5}.		negative regulation of short-term synaptic potentiation [GO:1905513]; negative regulation of SNARE complex assembly [GO:0035544]; neuromuscular process controlling posture [GO:0050884]; regulation of calcium-dependent activation of synaptic vesicle fusion [GO:0150037]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]	axon terminus [GO:0043679]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982]	syntaxin-1 binding [GO:0017075]	axon terminus [GO:0043679]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982]; syntaxin-1 binding [GO:0017075]; negative regulation of short-term synaptic potentiation [GO:1905513]; negative regulation of SNARE complex assembly [GO:0035544]; neuromuscular process controlling posture [GO:0050884]; regulation of calcium-dependent activation of synaptic vesicle fusion [GO:0150037]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22101681, ECO:0000269|PubMed:25915028, ECO:0000269|PubMed:27172900}; Single-pass membrane protein {ECO:0000250|UniProtKB:E9PUL5}. Presynaptic cell membrane {ECO:0000250|UniProtKB:E9PUL5}; Single-pass membrane protein {ECO:0000250|UniProtKB:E9PUL5}. Synapse {ECO:0000250|UniProtKB:E9PUL5}. Cell projection, axon {ECO:0000269|PubMed:22832103}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:D3ZFB6}. Postsynaptic density membrane {ECO:0000250|UniProtKB:D3ZFB6}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:D3ZFB6}.
Q7Z6L1	reviewed	TCPR1_HUMAN	Tectonin beta-propeller repeat-containing protein 1	TECPR1 KIAA1358	Homo sapiens (Human)	1165	FUNCTION: Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. {ECO:0000269|PubMed:21575909, ECO:0000269|PubMed:22342342}.		autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; macroautophagy [GO:0016236]; regulation of autophagosome maturation [GO:1901096]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	phosphatidylinositol-3-phosphate binding [GO:0032266]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; phosphatidylinositol-3-phosphate binding [GO:0032266]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; macroautophagy [GO:0016236]; regulation of autophagosome maturation [GO:1901096]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.
Q7Z6M1	reviewed	RABEK_HUMAN	Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40)	RABEPK RAB9P40	Homo sapiens (Human)	372	FUNCTION: Rab9 effector required for endosome to trans-Golgi network (TGN) transport. {ECO:0000269|PubMed:9230071}.		receptor-mediated endocytosis [GO:0006898]; vesicle docking involved in exocytosis [GO:0006904]	cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]		cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; receptor-mediated endocytosis [GO:0006898]; vesicle docking involved in exocytosis [GO:0006904]	SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane {ECO:0000269|PubMed:14530284}. Note=Interaction with PIKFYVE and subsequent phosphorylation recruits it to the endosomal membrane. {ECO:0000269|PubMed:14530284}.
Q7Z6M3	reviewed	MILR1_HUMAN	Allergin-1 (Allergy inhibitory receptor 1) (Mast cell antigen 32) (MCA-32) (Mast cell immunoglobulin-like receptor 1)	MILR1 C17orf60 MCA32	Homo sapiens (Human)	343	FUNCTION: Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity). {ECO:0000250}.		cell surface receptor signaling pathway [GO:0007166]; mast cell degranulation [GO:0043303]; negative regulation of mast cell activation [GO:0033004]	plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; mast cell degranulation [GO:0043303]; negative regulation of mast cell activation [GO:0033004]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20526344}; Single-pass type I membrane protein {ECO:0000269|PubMed:20526344}.
Q7Z6M4	reviewed	MTEF4_HUMAN	Transcription termination factor 4, mitochondrial (Mitochondrial transcription termination factor 4) (mTERF domain-containing protein 2) [Cleaved into: mTERF domain-containing protein 2 processed]	MTERF4 MTERFD2 HSPC096	Homo sapiens (Human)	381	FUNCTION: Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S). {ECO:0000269|PubMed:21531335}.		camera-type eye development [GO:0043010]; heart development [GO:0007507]; mitochondrial ribosome assembly [GO:0061668]; mitochondrial transcription [GO:0006390]; protein targeting to mitochondrion [GO:0006626]; regulation of DNA-templated transcription [GO:0006355]; rRNA processing [GO:0006364]	cytosol [GO:0005829]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	double-stranded DNA binding [GO:0003690]; rRNA binding [GO:0019843]	cytosol [GO:0005829]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; double-stranded DNA binding [GO:0003690]; rRNA binding [GO:0019843]; camera-type eye development [GO:0043010]; heart development [GO:0007507]; mitochondrial ribosome assembly [GO:0061668]; mitochondrial transcription [GO:0006390]; protein targeting to mitochondrion [GO:0006626]; regulation of DNA-templated transcription [GO:0006355]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:22949673, ECO:0000269|PubMed:23022348}.
Q7Z6R9	reviewed	AP2D_HUMAN	Transcription factor AP-2-delta (AP2-delta) (Activating enhancer-binding protein 2-delta) (Transcription factor AP-2-beta-like 1)	TFAP2D TFAP2BL1	Homo sapiens (Human)	452	FUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). {ECO:0000250}.		anatomical structure development [GO:0048856]; inferior colliculus development [GO:0061379]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; anatomical structure development [GO:0048856]; inferior colliculus development [GO:0061379]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q7Z6V5	reviewed	ADAT2_HUMAN	tRNA-specific adenosine deaminase 2 (EC 3.5.4.33) (Deaminase domain-containing protein 1) (tRNA-specific adenosine-34 deaminase subunit ADAT2)	ADAT2 DEADC1	Homo sapiens (Human)	191	FUNCTION: Probably participates in deamination of adenosine-34 to inosine in many tRNAs. {ECO:0000250}.		tRNA wobble adenosine to inosine editing [GO:0002100]	nucleoplasm [GO:0005654]	tRNA-specific adenosine-34 deaminase activity [GO:0052717]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; tRNA-specific adenosine-34 deaminase activity [GO:0052717]; zinc ion binding [GO:0008270]; tRNA wobble adenosine to inosine editing [GO:0002100]	
Q7Z6Z7	reviewed	HUWE1_HUMAN	E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)	HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272	Homo sapiens (Human)	4374	FUNCTION: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15989957, PubMed:19713937, PubMed:15567145, PubMed:15767685, PubMed:18488021, PubMed:17567951, PubMed:19037095, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). {ECO:0000250|UniProtKB:P51593, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.		base-excision repair [GO:0006284]; cell differentiation [GO:0030154]; circadian regulation of gene expression [GO:0032922]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of mitochondrial fusion [GO:0010637]; positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]	DNA binding [GO:0003677]; histone ubiquitin ligase activity [GO:0140852]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; DNA binding [GO:0003677]; histone ubiquitin ligase activity [GO:0140852]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; base-excision repair [GO:0006284]; cell differentiation [GO:0030154]; circadian regulation of gene expression [GO:0032922]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of mitochondrial fusion [GO:0010637]; positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19713937}. Nucleus {ECO:0000269|PubMed:19713937}. Mitochondrion {ECO:0000269|PubMed:30217973}. Note=Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells (By similarity). Recruited to mitochondria following interaction with AMBRA1 (PubMed:30217973). {ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:30217973}.
Q7Z739	reviewed	YTHD3_HUMAN	YTH domain-containing family protein 3 (DF3)	YTHDF3	Homo sapiens (Human)	585	FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28106072, PubMed:28106076, PubMed:28281539, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28281539, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:28106076, PubMed:32492408). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31388144, PubMed:31292544, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (PubMed:32194978). {ECO:0000250|UniProtKB:Q8BYK6, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:28106076, ECO:0000269|PubMed:28281539, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32194978, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection (PubMed:32053707). May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome (PubMed:32053707). {ECO:0000269|PubMed:32053707}.		mRNA destabilization [GO:0061157]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; organelle assembly [GO:0070925]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of mRNA stability [GO:0043488]; regulation of trophoblast cell migration [GO:1901163]; stress granule assembly [GO:0034063]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; P-body [GO:0000932]	mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; P-body [GO:0000932]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; mRNA destabilization [GO:0061157]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; organelle assembly [GO:0070925]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of mRNA stability [GO:0043488]; regulation of trophoblast cell migration [GO:1901163]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:32492408, ECO:0000305|PubMed:28106072}. Cytoplasm, P-body {ECO:0000269|PubMed:32492408}. Cytoplasm, Stress granule {ECO:0000269|PubMed:32451507}.
Q7Z769	reviewed	S35E3_HUMAN	Solute carrier family 35 member E3 (Bladder cancer-overexpressed gene 1 protein)	SLC35E3 BLOV1 UNQ3043/PRO9859	Homo sapiens (Human)	313	FUNCTION: Putative transporter. {ECO:0000250}.			Golgi apparatus [GO:0005794]; membrane [GO:0016020]	antiporter activity [GO:0015297]; nucleotide-sugar transmembrane transporter activity [GO:0005338]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; antiporter activity [GO:0015297]; nucleotide-sugar transmembrane transporter activity [GO:0005338]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q7Z794	reviewed	K2C1B_HUMAN	Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)	KRT77 KRT1B	Homo sapiens (Human)	578		MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
Q7Z7A1	reviewed	CNTRL_HUMAN	Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110)	CNTRL CEP1 CEP110	Homo sapiens (Human)	2325	FUNCTION: Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. {ECO:0000269|PubMed:12732615, ECO:0000269|PubMed:16213214}.		aorta development [GO:0035904]; cell cycle [GO:0007049]; cell division [GO:0051301]; coronary vasculature development [GO:0060976]; kidney development [GO:0001822]; ventricular septum development [GO:0003281]	centriolar satellite [GO:0034451]; centriolar subdistal appendage [GO:0120103]; centrosome [GO:0005813]; cytosol [GO:0005829]; Flemming body [GO:0090543]; meiotic spindle pole [GO:0090619]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; mitotic spindle pole [GO:0097431]; perinuclear region of cytoplasm [GO:0048471]		centriolar satellite [GO:0034451]; centriolar subdistal appendage [GO:0120103]; centrosome [GO:0005813]; cytosol [GO:0005829]; Flemming body [GO:0090543]; meiotic spindle pole [GO:0090619]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; mitotic spindle pole [GO:0097431]; perinuclear region of cytoplasm [GO:0048471]; aorta development [GO:0035904]; cell cycle [GO:0007049]; cell division [GO:0051301]; coronary vasculature development [GO:0060976]; kidney development [GO:0001822]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10688839, ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:12732615, ECO:0000269|PubMed:14654843}. Midbody, Midbody ring {ECO:0000269|PubMed:12732615, ECO:0000269|PubMed:16213214}.
Q7Z7A4	reviewed	PXK_HUMAN	PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)	PXK	Homo sapiens (Human)	578	FUNCTION: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. {ECO:0000250|UniProtKB:Q8BX57, ECO:0000303|PubMed:16142408}.		early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; inflammatory response [GO:0006954]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of monoatomic ion transport [GO:0043271]; protein targeting to lysosome [GO:0006622]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extrinsic component of endosome membrane [GO:0031313]; late endosome [GO:0005770]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	actin binding [GO:0003779]; phosphatidylinositol binding [GO:0035091]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extrinsic component of endosome membrane [GO:0031313]; late endosome [GO:0005770]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; actin binding [GO:0003779]; phosphatidylinositol binding [GO:0035091]; early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; inflammatory response [GO:0006954]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of monoatomic ion transport [GO:0043271]; protein targeting to lysosome [GO:0006622]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16142408}. Cell membrane {ECO:0000269|PubMed:16142408}; Peripheral membrane protein {ECO:0000269|PubMed:16142408}. Note=Also associates with the plasma membrane. Isoform 3 is present throughout the cell.
Q7Z7B0	reviewed	FLIP1_HUMAN	Filamin-A-interacting protein 1 (FILIP)	FILIP1 KIAA1275	Homo sapiens (Human)	1213	FUNCTION: By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}.		modification of postsynaptic structure [GO:0099010]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]		actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; modification of postsynaptic structure [GO:0099010]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23087206}.
Q7Z7C7	reviewed	STRA8_HUMAN	Stimulated by retinoic acid gene 8 protein homolog	STRA8	Homo sapiens (Human)	330	FUNCTION: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. {ECO:0000250|UniProtKB:P70278}.		activation of meiosis [GO:0090427]; cellular response to retinoic acid [GO:0071300]; DNA replication [GO:0006260]; meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	protein dimerization activity [GO:0046983]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein dimerization activity [GO:0046983]; activation of meiosis [GO:0090427]; cellular response to retinoic acid [GO:0071300]; DNA replication [GO:0006260]; meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P70278}. Nucleus {ECO:0000250|UniProtKB:P70278}. Note=Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent. {ECO:0000250|UniProtKB:P70278}.
Q7Z7C8	reviewed	TAF8_HUMAN	Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43)	TAF8 TAFII43 TBN	Homo sapiens (Human)	310	FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF8 is involved in forming the TFIID-B module, together with TAF5 (PubMed:33795473). Mediates both basal and activator-dependent transcription (PubMed:14580349). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349). Required for the integration of TAF10 in the TAF complex (PubMed:14580349). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). {ECO:0000250|UniProtKB:Q9EQH4, ECO:0000269|PubMed:14580349, ECO:0000269|PubMed:33795473}.	MISCELLANEOUS: 'Taube nuss' means 'empty nut' in German.	cell differentiation [GO:0030154]; DNA-templated transcription open complex formation [GO:0001112]; inner cell mass cell proliferation [GO:0001833]; maintenance of protein location in nucleus [GO:0051457]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of fat cell differentiation [GO:0045598]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; cell differentiation [GO:0030154]; DNA-templated transcription open complex formation [GO:0001112]; inner cell mass cell proliferation [GO:0001833]; maintenance of protein location in nucleus [GO:0051457]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of fat cell differentiation [GO:0045598]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14580349, ECO:0000269|PubMed:35759269}. Cytoplasm {ECO:0000269|PubMed:35759269}. Note=Predominantly nuclear. {ECO:0000269|PubMed:35759269}.
Q7Z7D3	reviewed	VTCN1_HUMAN	V-set domain-containing T-cell activation inhibitor 1 (B7 homolog 4) (B7-H4) (B7h.5) (Immune costimulatory protein B7-H4) (Protein B7S1) (T-cell costimulatory molecule B7x)	VTCN1 B7H4 UNQ659/PRO1291	Homo sapiens (Human)	282	FUNCTION: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. {ECO:0000250|UniProtKB:Q7TSP5, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:17509674, ECO:0000269|PubMed:17875732}.	MISCELLANEOUS: May serve as a predictive marker for renal cell carcinoma. {ECO:0000269|PubMed:16798883}.	adaptive immune response [GO:0002250]; negative regulation of apoptotic process [GO:0043066]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of T cell proliferation [GO:0042102]; regulation of cytokine production [GO:0001817]; response to protozoan [GO:0001562]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; signaling receptor binding [GO:0005102]; adaptive immune response [GO:0002250]; negative regulation of apoptotic process [GO:0043066]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of T cell proliferation [GO:0042102]; regulation of cytokine production [GO:0001817]; response to protozoan [GO:0001562]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000305}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16782226}.
Q7Z7E8	reviewed	UB2Q1_HUMAN	Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Protein NICE-5) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1)	UBE2Q1 NICE5 UBE2Q PRO3094	Homo sapiens (Human)	422	FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity). {ECO:0000250|UniProtKB:Q7TSS2, ECO:0000269|PubMed:22496338}.		embryo implantation [GO:0007566]; fertilization [GO:0009566]; mating behavior [GO:0007617]; prolactin secretion [GO:0070459]; protein ubiquitination [GO:0016567]; reproductive system development [GO:0061458]; suckling behavior [GO:0001967]	cytosol [GO:0005829]; filopodium [GO:0030175]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]	cytosol [GO:0005829]; filopodium [GO:0030175]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; embryo implantation [GO:0007566]; fertilization [GO:0009566]; mating behavior [GO:0007617]; prolactin secretion [GO:0070459]; protein ubiquitination [GO:0016567]; reproductive system development [GO:0061458]; suckling behavior [GO:0001967]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7TSS2}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q7TSS2}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q7TSS2}.
Q7Z7F0	reviewed	KHDC4_HUMAN	KH homology domain-containing protein 4 (Brings lots of money 7) (Pre-mRNA splicing factor protein KHDC4)	KHDC4 BLOM7 KIAA0907 SNORA80EHG	Homo sapiens (Human)	614	FUNCTION: RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703). {ECO:0000269|PubMed:19641227, ECO:0000269|PubMed:23144703}.	MISCELLANEOUS: [Isoform 2]: Interacts with U2AF65. {ECO:0000269|PubMed:19641227}.	mRNA splice site recognition [GO:0006376]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA splice site recognition [GO:0006376]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19641227, ECO:0000269|PubMed:23144703}. Cytoplasm {ECO:0000269|PubMed:19641227}.
Q7Z7G0	reviewed	TARSH_HUMAN	Target of Nesh-SH3 (Tarsh) (ABI gene family member 3-binding protein) (Nesh-binding protein) (NeshBP)	ABI3BP NESHBP TARSH	Homo sapiens (Human)	1068			extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]		collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q7Z7G1	reviewed	CLNK_HUMAN	Cytokine-dependent hematopoietic cell linker (Mast cell immunoreceptor signal transducer)	CLNK MIST	Homo sapiens (Human)	428	FUNCTION: An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (By similarity). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (By similarity). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (By similarity). Involved in phosphorylation of LAT (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:Q9QZE2}.		intracellular signal transduction [GO:0035556]; mast cell degranulation [GO:0043303]; negative regulation of natural killer cell activation [GO:0032815]; positive regulation of natural killer cell cytokine production [GO:0002729]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; mast cell granule [GO:0042629]; protein-containing complex [GO:0032991]	protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; mast cell granule [GO:0042629]; protein-containing complex [GO:0032991]; protein-containing complex binding [GO:0044877]; intracellular signal transduction [GO:0035556]; mast cell degranulation [GO:0043303]; negative regulation of natural killer cell activation [GO:0032815]; positive regulation of natural killer cell cytokine production [GO:0002729]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26009488}.
Q7Z7G2	reviewed	CPLX4_HUMAN	Complexin-4 (Complexin IV) (CPX IV)	CPLX4	Homo sapiens (Human)	160	FUNCTION: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). {ECO:0000250|UniProtKB:Q80WM3}.		regulation of neurotransmitter secretion [GO:0046928]; response to stimulus [GO:0050896]; synaptic vesicle exocytosis [GO:0016079]; visual perception [GO:0007601]	plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; terminal bouton [GO:0043195]	SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]	plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; terminal bouton [GO:0043195]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; regulation of neurotransmitter secretion [GO:0046928]; response to stimulus [GO:0050896]; synaptic vesicle exocytosis [GO:0016079]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q80WM3}. Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q80WM3}. Note=Enriched at the synaptic terminal. {ECO:0000250|UniProtKB:Q80WM3}.
Q7Z7G8	reviewed	VP13B_HUMAN	Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B)	VPS13B CHS1 COH1 KIAA0532	Homo sapiens (Human)	4022	FUNCTION: Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:30962439, PubMed:24334764, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}.		acrosome assembly [GO:0001675]; adipose tissue development [GO:0060612]; central nervous system development [GO:0007417]; Golgi organization [GO:0007030]; Golgi reassembly [GO:0090168]; lipid transport [GO:0006869]; maintenance of lens transparency [GO:0036438]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; slow endocytic recycling [GO:0032458]; vesicle-mediated transport [GO:0016192]	acrosomal membrane [GO:0002080]; cis-Golgi network membrane [GO:0033106]; early endosome membrane [GO:0031901]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]	phosphatidylinositol-3-phosphate binding [GO:0032266]	acrosomal membrane [GO:0002080]; cis-Golgi network membrane [GO:0033106]; early endosome membrane [GO:0031901]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]; phosphatidylinositol-3-phosphate binding [GO:0032266]; acrosome assembly [GO:0001675]; adipose tissue development [GO:0060612]; central nervous system development [GO:0007417]; Golgi organization [GO:0007030]; Golgi reassembly [GO:0090168]; lipid transport [GO:0006869]; maintenance of lens transparency [GO:0036438]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; slow endocytic recycling [GO:0032458]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:Q80TY5}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q80TY5}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:25492866}; Peripheral membrane protein {ECO:0000269|PubMed:21865173}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:21865173}; Peripheral membrane protein {ECO:0000269|PubMed:21865173}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21865173}; Peripheral membrane protein {ECO:0000269|PubMed:21865173}. Early endosome membrane {ECO:0000269|PubMed:25492866}; Peripheral membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:25492866}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to proacrosomal and acrosomal vesicles and not the Golgi apparatus during acrosome formation. {ECO:0000250|UniProtKB:Q80TY5}.
Q7Z7H3	reviewed	CATIP_HUMAN	Ciliogenesis-associated TTC17-interacting protein	CATIP C2orf62	Homo sapiens (Human)	387	FUNCTION: Plays a role in primary ciliogenesis by modulating actin polymerization. {ECO:0000269|PubMed:24475127, ECO:0000269|PubMed:32503832}.		actin filament polymerization [GO:0030041]; cilium organization [GO:0044782]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; actin filament polymerization [GO:0030041]; cilium organization [GO:0044782]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24475127, ECO:0000269|PubMed:32503832}. Cytoplasm {ECO:0000269|PubMed:24475127, ECO:0000269|PubMed:32503832}. Cell membrane {ECO:0000269|PubMed:24475127}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24475127}. Note=Colocalized with TTC17 at F-actin rich zones and at dynamic plasma membrane protrusions.
Q7Z7H5	reviewed	TMED4_HUMAN	Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3)	TMED4 ERS25	Homo sapiens (Human)	227	FUNCTION: Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity). {ECO:0000250}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]		COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q7Z7H8	reviewed	RM10_HUMAN	Large ribosomal subunit protein uL10m (39S ribosomal protein L10, mitochondrial) (L10mt) (MRP-L10) (39S ribosomal protein L8, mitochondrial) (L8mt) (MRP-L8)	MRPL10 MRPL8 RPML8	Homo sapiens (Human)	261			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q7Z7K6	reviewed	CENPV_HUMAN	Centromere protein V (CENP-V) (Nuclear protein p30) (Proline-rich protein 6)	CENPV PRR6	Homo sapiens (Human)	275	FUNCTION: Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis. {ECO:0000269|PubMed:18772885}.		ameboidal-type cell migration [GO:0001667]; cell cycle [GO:0007049]; cell division [GO:0051301]; centromere complex assembly [GO:0034508]; pericentric heterochromatin formation [GO:0031508]; positive regulation of cytokinesis [GO:0032467]; regulation of chromosome organization [GO:0033044]	cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle midzone [GO:0051233]	carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle midzone [GO:0051233]; carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872]; ameboidal-type cell migration [GO:0001667]; cell cycle [GO:0007049]; cell division [GO:0051301]; centromere complex assembly [GO:0034508]; pericentric heterochromatin formation [GO:0031508]; positive regulation of cytokinesis [GO:0032467]; regulation of chromosome organization [GO:0033044]	SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:18772885}. Nucleus {ECO:0000269|PubMed:12196509}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18772885}. Note=Enriched at the nuclear periphery and around the nucleolus (PubMed:12196509). In mitotic cells, localizes to kinetochores from prometaphase to metaphase (PubMed:18772885). At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis (PubMed:18772885).
Q7Z7L1	reviewed	SLN11_HUMAN	Schlafen family member 11 (EC 3.6.-.-)	SLFN11	Homo sapiens (Human)	901	FUNCTION: Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900). Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061}.	MISCELLANEOUS: Dominant determinant of sensitivity to DNA-damaging anticancer drugs: acts by mediating cell death in response to DNA damage induced by anticancer drugs (PubMed:29395061). Down-regulated in a number of chemoresistant tumors (PubMed:26625211, PubMed:28196596, PubMed:27440269, PubMed:28212573). {ECO:0000269|PubMed:26625211, ECO:0000269|PubMed:27440269, ECO:0000269|PubMed:28196596, ECO:0000269|PubMed:28212573, ECO:0000269|PubMed:29395061}.	chromatin remodeling [GO:0006338]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune system process [GO:0002376]; negative regulation of DNA replication [GO:0008156]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; replication fork arrest [GO:0043111]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; tRNA binding [GO:0000049]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; tRNA binding [GO:0000049]; chromatin remodeling [GO:0006338]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune system process [GO:0002376]; negative regulation of DNA replication [GO:0008156]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; replication fork arrest [GO:0043111]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061}. Chromosome {ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061}. Note=Recruited to stressed replication forks carrying extended RPA filaments (PubMed:29395061). Recruited to DNA damage sites via interaction with RPA1 (PubMed:26658330, PubMed:29395061). {ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061}.
Q7Z7L7	reviewed	ZER1_HUMAN	Protein zer-1 homolog (Hzyg) (Zyg-11 homolog B-like protein) (Zyg11b-like protein)	ZER1 C9orf60 ZYG ZYG11BL	Homo sapiens (Human)	766	FUNCTION: Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC (PubMed:17304241, PubMed:31273098). Acts to target substrates bearing N-terminal degrons for proteasomal degradation with the first four residues of substrates being the key recognition elements (PubMed:33093214, PubMed:34214466, PubMed:36496439). Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098). {ECO:0000269|PubMed:17304241, ECO:0000269|PubMed:31273098, ECO:0000269|PubMed:33093214, ECO:0000269|PubMed:34214466, ECO:0000269|PubMed:36496439}.		positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]	Cul2-RING ubiquitin ligase complex [GO:0031462]		Cul2-RING ubiquitin ligase complex [GO:0031462]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]	
Q7Z7M0	reviewed	MEGF8_HUMAN	Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4)	MEGF8 C19orf49 EGFL4 KIAA0817	Homo sapiens (Human)	2845	FUNCTION: Acts as a negative regulator of hedgehog signaling. {ECO:0000250|UniProtKB:P60882}.		BMP signaling pathway [GO:0030509]; cell migration involved in gastrulation [GO:0042074]; coronary vasculature development [GO:0060976]; craniofacial suture morphogenesis [GO:0097094]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of heart left/right asymmetry [GO:0061371]; embryonic heart tube left/right pattern formation [GO:0060971]; embryonic heart tube morphogenesis [GO:0003143]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; epiboly involved in gastrulation with mouth forming second [GO:0055113]; fasciculation of sensory neuron axon [GO:0097155]; left/right pattern formation [GO:0060972]; limb morphogenesis [GO:0035108]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of axon extension involved in axon guidance [GO:0048842]; regulation of gene expression [GO:0010468]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; BMP signaling pathway [GO:0030509]; cell migration involved in gastrulation [GO:0042074]; coronary vasculature development [GO:0060976]; craniofacial suture morphogenesis [GO:0097094]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of heart left/right asymmetry [GO:0061371]; embryonic heart tube left/right pattern formation [GO:0060971]; embryonic heart tube morphogenesis [GO:0003143]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; epiboly involved in gastrulation with mouth forming second [GO:0055113]; fasciculation of sensory neuron axon [GO:0097155]; left/right pattern formation [GO:0060972]; limb morphogenesis [GO:0035108]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of axon extension involved in axon guidance [GO:0048842]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q7Z7M8	reviewed	B3GN8_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 (BGnT-8) (Beta-1,3-Gn-T8) (Beta-1,3-N-acetylglucosaminyltransferase 8) (Beta3Gn-T8) (EC 2.4.1.-)	B3GNT8 B3GALT7 BGALT15	Homo sapiens (Human)	397	FUNCTION: Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans. {ECO:0000269|PubMed:15620693, ECO:0000269|PubMed:15917431}.		O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	protein N-acetylglucosaminyltransferase activity [GO:0016262]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; protein N-acetylglucosaminyltransferase activity [GO:0016262]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NY97}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9NY97}.
Q7Z7M9	reviewed	GALT5_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 5 (EC 2.4.1.41) (Polypeptide GalNAc transferase 5) (GalNAc-T5) (pp-GaNTase 5) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5)	GALNT5	Homo sapiens (Human)	940	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity). {ECO:0000250}.		glycosaminoglycan biosynthetic process [GO:0006024]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; glycosaminoglycan biosynthetic process [GO:0006024]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q7Z7N9	reviewed	T179B_HUMAN	Transmembrane protein 179B	TMEM179B	Homo sapiens (Human)	219				azurophil granule membrane [GO:0035577]; ficolin-1-rich granule membrane [GO:0101003]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]		azurophil granule membrane [GO:0035577]; ficolin-1-rich granule membrane [GO:0101003]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q86SE5	reviewed	RALYL_HUMAN	RNA-binding Raly-like protein (hRALYL) (Heterogeneous nuclear ribonucleoprotein C-like 3) (hnRNP core protein C-like 3)	RALYL HNRPCL3	Homo sapiens (Human)	291				nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]	
Q86SE8	reviewed	NPM2_HUMAN	Nucleoplasmin-2	NPM2	Homo sapiens (Human)	214	FUNCTION: Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. {ECO:0000269|PubMed:21863821}.		blastocyst development [GO:0001824]; chromatin remodeling [GO:0006338]; oocyte differentiation [GO:0009994]; positive regulation of DNA replication [GO:0045740]; positive regulation of meiotic nuclear division [GO:0045836]; regulation of exit from mitosis [GO:0007096]; single fertilization [GO:0007338]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; blastocyst development [GO:0001824]; chromatin remodeling [GO:0006338]; oocyte differentiation [GO:0009994]; positive regulation of DNA replication [GO:0045740]; positive regulation of meiotic nuclear division [GO:0045836]; regulation of exit from mitosis [GO:0007096]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm. {ECO:0000250}.
Q86SE9	reviewed	PCGF5_HUMAN	Polycomb group RING finger protein 5 (RING finger protein 159)	PCGF5 RNF159	Homo sapiens (Human)	256	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). {ECO:0000250|UniProtKB:Q3UK78, ECO:0000269|PubMed:26151332}.		inactivation of X chromosome by genomic imprinting [GO:0060819]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; X chromosome [GO:0000805]	histone H2AK119 ubiquitin ligase activity [GO:0140862]; metal ion binding [GO:0046872]	centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; X chromosome [GO:0000805]; histone H2AK119 ubiquitin ligase activity [GO:0140862]; metal ion binding [GO:0046872]; inactivation of X chromosome by genomic imprinting [GO:0060819]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530, ECO:0000269|PubMed:25519132}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q3UK78}. Note=Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome. {ECO:0000250|UniProtKB:Q3UK78}.
Q86SF2	reviewed	GALT7_HUMAN	N-acetylgalactosaminyltransferase 7 (EC 2.4.1.41) (Polypeptide GalNAc transferase 7) (GalNAc-T7) (pp-GaNTase 7) (Protein-UDP acetylgalactosaminyltransferase 7) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7)	GALNT7	Homo sapiens (Human)	657	FUNCTION: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. {ECO:0000269|PubMed:10544240, ECO:0000269|PubMed:11925450}.		carbohydrate metabolic process [GO:0005975]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; carbohydrate metabolic process [GO:0005975]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q86SG2	reviewed	ANR23_HUMAN	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3)	ANKRD23 DARP	Homo sapiens (Human)	305	FUNCTION: May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.		fatty acid metabolic process [GO:0006631]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of sarcomere organization [GO:0060297]; response to muscle stretch [GO:0035994]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; I band [GO:0031674]; intercalated disc [GO:0014704]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	titin binding [GO:0031432]; transcription cis-regulatory region binding [GO:0000976]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; I band [GO:0031674]; intercalated disc [GO:0014704]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; titin binding [GO:0031432]; transcription cis-regulatory region binding [GO:0000976]; fatty acid metabolic process [GO:0006631]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of sarcomere organization [GO:0060297]; response to muscle stretch [GO:0035994]	SUBCELLULAR LOCATION: Nucleus. Note=Sarcomeric I-band and some intercalated disks. {ECO:0000250}.
Q86SG3	reviewed	DAZ4_HUMAN	Deleted in azoospermia protein 4	DAZ4	Homo sapiens (Human)	579	FUNCTION: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.	MISCELLANEOUS: DAZ genes are prone to deletions but also to duplications. In a population of infertile men, DAZ genes deletions are associated with oligozoospermia but an increased number of DAZ genes is not a significant risk factor for spermatogenic failure.; MISCELLANEOUS: The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated region of the Y chromosome, in two clusters each comprising an inverted pair of DAZ genes. They are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a DAZ protein involve all the 4 proteins.	3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	mRNA 3'-UTR binding [GO:0003730]; translation activator activity [GO:0008494]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; mRNA 3'-UTR binding [GO:0003730]; translation activator activity [GO:0008494]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11058556}. Nucleus {ECO:0000269|PubMed:11058556}. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
Q86SG5	reviewed	S1A7A_HUMAN	Protein S100-A7A (S100 calcium-binding protein A15) (S100 calcium-binding protein A7-like 1) (S100 calcium-binding protein A7A)	S100A7A S100A15 S100A7L1	Homo sapiens (Human)	101	FUNCTION: May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein self-association [GO:0043621]; transition metal ion binding [GO:0046914]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein self-association [GO:0043621]; transition metal ion binding [GO:0046914]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q86SG6	reviewed	NEK8_HUMAN	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a)	NEK8 JCK NEK12A	Homo sapiens (Human)	692	FUNCTION: Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. {ECO:0000250, ECO:0000269|PubMed:23418306}.		animal organ morphogenesis [GO:0009887]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; phosphorylation [GO:0016310]; regulation of hippo signaling [GO:0035330]	ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; animal organ morphogenesis [GO:0009887]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; phosphorylation [GO:0016310]; regulation of hippo signaling [GO:0035330]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18199800}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91ZR4}. Cell projection, cilium {ECO:0000269|PubMed:18199800}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18199800}. Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells. {ECO:0000250|UniProtKB:Q91ZR4}.
Q86SJ2	reviewed	AMGO2_HUMAN	Amphoterin-induced protein 2 (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA)	AMIGO2 ALI1	Homo sapiens (Human)	522	FUNCTION: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.		brain development [GO:0007420]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of programmed cell death [GO:0043069]; positive regulation of synapse assembly [GO:0051965]	nucleus [GO:0005634]; plasma membrane [GO:0005886]		nucleus [GO:0005634]; plasma membrane [GO:0005886]; brain development [GO:0007420]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of programmed cell death [GO:0043069]; positive regulation of synapse assembly [GO:0051965]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). {ECO:0000250}.
Q86SJ6	reviewed	DSG4_HUMAN	Desmoglein-4 (Cadherin family member 13)	DSG4 CDHF13	Homo sapiens (Human)	1040	FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). {ECO:0000250}.		BMP signaling pathway [GO:0030509]; cell-cell adhesion [GO:0098609]; hair follicle development [GO:0001942]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte differentiation [GO:0030216]	cornified envelope [GO:0001533]; desmosome [GO:0030057]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	cornified envelope [GO:0001533]; desmosome [GO:0030057]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; BMP signaling pathway [GO:0030509]; cell-cell adhesion [GO:0098609]; hair follicle development [GO:0001942]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte differentiation [GO:0030216]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, desmosome {ECO:0000250}.
Q86SK9	reviewed	SCD5_HUMAN	Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (HSCD5) (Stearoyl-CoA 9-desaturase) (Stearoyl-CoA desaturase 2)	SCD5 ACOD4 SCD2 SCD4	Homo sapiens (Human)	330	FUNCTION: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15610069, PubMed:15907797, PubMed:22745828). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069, PubMed:15907797). Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed:22745828). {ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:22745828}.	MISCELLANEOUS: This protein has no ortholog in rodents. {ECO:0000305}.	unsaturated fatty acid biosynthetic process [GO:0006636]	endoplasmic reticulum membrane [GO:0005789]	metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; stearoyl-CoA 9-desaturase activity [GO:0004768]	endoplasmic reticulum membrane [GO:0005789]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; stearoyl-CoA 9-desaturase activity [GO:0004768]; unsaturated fatty acid biosynthetic process [GO:0006636]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:22745828}; Multi-pass membrane protein {ECO:0000255}.
Q86SQ0	reviewed	PHLB2_HUMAN	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)	PHLDB2 LL5B	Homo sapiens (Human)	1253	FUNCTION: Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.		cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; establishment of protein localization [GO:0045184]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]	basal cortex [GO:0045180]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]	basal cortex [GO:0045180]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; establishment of protein localization [GO:0045184]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12376540}. Membrane {ECO:0000269|PubMed:12376540}; Peripheral membrane protein {ECO:0000269|PubMed:12376540}. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments.
Q86SQ3	reviewed	AGRE4_HUMAN	Putative adhesion G protein-coupled receptor E4P (EGF-like module receptor 4) (EGF-like module-containing mucin-like hormone receptor-like 4) (G-protein coupled receptor 127) (G-protein coupled receptor PGR16)	ADGRE4P EMR4 EMR4P GPR127 PGR16	Homo sapiens (Human)	457	FUNCTION: May mediate the cellular interaction between myeloid cells and B-cells. {ECO:0000250|UniProtKB:Q91ZE5}.	MISCELLANEOUS: [Isoform 2]: Due to a frameshift mutation in exon 8 would result in a truncated soluble form. {ECO:0000305}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:Q91ZE5}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q86SQ4	reviewed	AGRG6_HUMAN	Adhesion G-protein coupled receptor G6 (Developmentally regulated G-protein-coupled receptor) (G-protein coupled receptor 126) (Vascular inducible G protein-coupled receptor) [Cleaved into: ADGRG6 N-terminal fragment (ADGRG6-NTF); ADGRG6 C-terminal fragment (ADGRG6-CTF)]	ADGRG6 DREG GPR126 VIGR	Homo sapiens (Human)	1221	FUNCTION: G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity). {ECO:0000250|UniProtKB:C6KFA3, ECO:0000269|PubMed:24227709, ECO:0000269|PubMed:26004201}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP-mediated signaling [GO:0019933]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; heart trabecula formation [GO:0060347]; myelination [GO:0042552]; myelination in peripheral nervous system [GO:0022011]; nervous system development [GO:0007399]; Schwann cell differentiation [GO:0014037]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	collagen binding [GO:0005518]; endopeptidase activity [GO:0004175]; extracellular matrix binding [GO:0050840]; G protein-coupled receptor activity [GO:0004930]; laminin binding [GO:0043236]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; collagen binding [GO:0005518]; endopeptidase activity [GO:0004175]; extracellular matrix binding [GO:0050840]; G protein-coupled receptor activity [GO:0004930]; laminin binding [GO:0043236]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP-mediated signaling [GO:0019933]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; heart trabecula formation [GO:0060347]; myelination [GO:0042552]; myelination in peripheral nervous system [GO:0022011]; nervous system development [GO:0007399]; Schwann cell differentiation [GO:0014037]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15189448, ECO:0000269|PubMed:15225624, ECO:0000269|PubMed:24227709}; Multi-pass membrane protein {ECO:0000255}. Note=Detected on the cell surface of activated but not resting umbilical vein. {ECO:0000269|PubMed:15225624}.
Q86SQ6	reviewed	AGRA1_HUMAN	Adhesion G protein-coupled receptor A1 (G-protein coupled receptor 123)	ADGRA1 GPR123 KIAA1828	Homo sapiens (Human)	560	FUNCTION: Orphan receptor.		cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]	glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	G protein-coupled receptor activity [GO:0004930]	glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; G protein-coupled receptor activity [GO:0004930]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q86SQ7	reviewed	SDCG8_HUMAN	Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP)	SDCCAG8 CCCAP NPHP10 HSPC085	Homo sapiens (Human)	713	FUNCTION: Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). {ECO:0000250|UniProtKB:Q80UF4, ECO:0000269|PubMed:27224062}.		cell projection organization [GO:0030030]; centrosome cycle [GO:0007098]; establishment of cell polarity [GO:0030010]; microtubule organizing center organization [GO:0031023]; neuron migration [GO:0001764]; regulation of cilium assembly [GO:1902017]; tube formation [GO:0035148]	cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; photoreceptor cell cilium [GO:0097733]		cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; photoreceptor cell cilium [GO:0097733]; cell projection organization [GO:0030030]; centrosome cycle [GO:0007098]; establishment of cell polarity [GO:0030010]; microtubule organizing center organization [GO:0031023]; neuron migration [GO:0001764]; regulation of cilium assembly [GO:1902017]; tube formation [GO:0035148]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27224062}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27224062}. Cell junction. Note=Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Q86SQ9	reviewed	DHDDS_HUMAN	Dehydrodolichyl diphosphate synthase complex subunit DHDDS (EC 2.5.1.87) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Cis-prenyltransferase subunit hCIT) (Epididymis tissue protein Li 189m)	DHDDS HDS	Homo sapiens (Human)	333	FUNCTION: With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490, PubMed:32817466). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). {ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056, ECO:0000269|PubMed:28842490, ECO:0000269|PubMed:32817466}.	MISCELLANEOUS: [Isoform 3]: May be due to exon skipping. {ECO:0000305}.	dolichyl diphosphate biosynthetic process [GO:0006489]; polyprenol biosynthetic process [GO:0016094]	dehydrodolichyl diphosphate synthase complex [GO:1904423]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	dehydrodolichyl diphosphate synthase activity [GO:0045547]; metal ion binding [GO:0046872]	dehydrodolichyl diphosphate synthase complex [GO:1904423]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; dehydrodolichyl diphosphate synthase activity [GO:0045547]; metal ion binding [GO:0046872]; dolichyl diphosphate biosynthetic process [GO:0006489]; polyprenol biosynthetic process [GO:0016094]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14652022}; Peripheral membrane protein {ECO:0000269|PubMed:14652022}. Note=colocalizes with calnexin.
Q86SR1	reviewed	GLT10_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 10 (EC 2.4.1.41) (Polypeptide GalNAc transferase 10) (GalNAc-T10) (pp-GaNTase 10) (Protein-UDP acetylgalactosaminyltransferase 10) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10)	GALNT10	Homo sapiens (Human)	603	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.		O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q86SS6	reviewed	SYT9_HUMAN	Synaptotagmin-9 (Synaptotagmin IX) (SytIX)	SYT9	Homo sapiens (Human)	491	FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.		calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]	clathrin-coated endocytic vesicle membrane [GO:0030669]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]	clathrin-coated endocytic vesicle membrane [GO:0030669]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q86SU0	reviewed	ILDR1_HUMAN	Immunoglobulin-like domain-containing receptor 1 (Angulin-2)	ILDR1	Homo sapiens (Human)	546	FUNCTION: Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) (PubMed:23239027). Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs. Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine. In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:Q8CBR1, ECO:0000269|PubMed:23239027}.; FUNCTION: (Microbial infection) Promotes influenza virus infection by inhibiting viral nucleoprotein NP binding to PLSCR1 and thereby PLSCR1-mediated antiviral activity. {ECO:0000269|PubMed:35595813}.		cellular response to leukemia inhibitory factor [GO:1990830]; epithelial structure maintenance [GO:0010669]; establishment of localization in cell [GO:0051649]; peptide hormone secretion [GO:0030072]; positive regulation of peptide hormone secretion [GO:0090277]; protein localization to tricellular tight junction [GO:0061833]; regulation of RNA splicing [GO:0043484]; response to fatty acid [GO:0070542]; tricellular tight junction assembly [GO:1904274]	bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]; tricellular tight junction [GO:0061689]	high-density lipoprotein particle receptor activity [GO:0070506]; identical protein binding [GO:0042802]	bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]; tricellular tight junction [GO:0061689]; high-density lipoprotein particle receptor activity [GO:0070506]; identical protein binding [GO:0042802]; cellular response to leukemia inhibitory factor [GO:1990830]; epithelial structure maintenance [GO:0010669]; establishment of localization in cell [GO:0051649]; peptide hormone secretion [GO:0030072]; positive regulation of peptide hormone secretion [GO:0090277]; protein localization to tricellular tight junction [GO:0061833]; regulation of RNA splicing [GO:0043484]; response to fatty acid [GO:0070542]; tricellular tight junction assembly [GO:1904274]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15381095}; Single-pass type I membrane protein {ECO:0000269|PubMed:15381095}. Cell junction, tight junction {ECO:0000269|PubMed:23239027}. Cytoplasm {ECO:0000269|PubMed:35595813}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm, cytosol {ECO:0000269|PubMed:15381095}.
Q86SX6	reviewed	GLRX5_HUMAN	Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5)	GLRX5 C14orf87	Homo sapiens (Human)	157	FUNCTION: Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:20364084, PubMed:23615440). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:20364084, PubMed:23615440, PubMed:24334290). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). {ECO:0000269|PubMed:20364084, ECO:0000269|PubMed:23615440, ECO:0000269|PubMed:24334290}.		[2Fe-2S] cluster assembly [GO:0044571]; cell redox homeostasis [GO:0045454]; hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [2Fe-2S] cluster transfer [GO:0106034]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]	dendrite [GO:0030425]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]	2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]	dendrite [GO:0030425]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; [2Fe-2S] cluster assembly [GO:0044571]; cell redox homeostasis [GO:0045454]; hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [2Fe-2S] cluster transfer [GO:0106034]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:20364084}.
Q86SZ2	reviewed	TPC6B_HUMAN	Trafficking protein particle complex subunit 6B (TRAPP complex subunit 6B)	TRAPPC6B	Homo sapiens (Human)	158	FUNCTION: Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (PubMed:16025134, PubMed:16828797). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable). {ECO:0000269|PubMed:16025134, ECO:0000269|PubMed:16828797, ECO:0000305|PubMed:28626029}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; nervous system development [GO:0007399]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; trans-Golgi network [GO:0005802]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]		cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; trans-Golgi network [GO:0005802]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; nervous system development [GO:0007399]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Q86T03	reviewed	PP4P1_HUMAN	Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 1 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Transmembrane protein 55B)	PIP4P1 C14orf9 TMEM55B	Homo sapiens (Human)	277	FUNCTION: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (PubMed:29146937). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (PubMed:25035345). {ECO:0000269|PubMed:16365287, ECO:0000269|PubMed:25035345, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:29644770}.	MISCELLANEOUS: [Isoform 3]: May be due to intron retention. {ECO:0000305}.	cholesterol metabolic process [GO:0008203]; lysosome localization [GO:0032418]; phosphatidylinositol dephosphorylation [GO:0046856]; phospholipid metabolic process [GO:0006644]; positive regulation of TORC1 signaling [GO:1904263]; proton-transporting V-type ATPase complex assembly [GO:0070070]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to sterol depletion [GO:0006991]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597]; cholesterol metabolic process [GO:0008203]; lysosome localization [GO:0032418]; phosphatidylinositol dephosphorylation [GO:0046856]; phospholipid metabolic process [GO:0006644]; positive regulation of TORC1 signaling [GO:1904263]; proton-transporting V-type ATPase complex assembly [GO:0070070]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to sterol depletion [GO:0006991]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:16365287}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:16365287}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q3TWL2}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q3TWL2}; Multi-pass membrane protein {ECO:0000255}.
Q86T13	reviewed	CLC14_HUMAN	C-type lectin domain family 14 member A (Epidermal growth factor receptor 5) (EGFR-5)	CLEC14A C14orf27 EGFR5 UNQ236/PRO269	Homo sapiens (Human)	490			cell migration [GO:0016477]; cell migration involved in sprouting angiogenesis [GO:0002042]; lymphangiogenesis [GO:0001946]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; vascular endothelial growth factor receptor-3 signaling pathway [GO:0036325]	collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]	carbohydrate binding [GO:0030246]; extracellular matrix binding [GO:0050840]; extracellular matrix protein binding [GO:1990430]	collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; carbohydrate binding [GO:0030246]; extracellular matrix binding [GO:0050840]; extracellular matrix protein binding [GO:1990430]; cell migration [GO:0016477]; cell migration involved in sprouting angiogenesis [GO:0002042]; lymphangiogenesis [GO:0001946]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; vascular endothelial growth factor receptor-3 signaling pathway [GO:0036325]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q86T24	reviewed	KAISO_HUMAN	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33)	ZBTB33 KAISO ZNF348	Homo sapiens (Human)	672	FUNCTION: Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). {ECO:0000269|PubMed:11445535, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:15548582, ECO:0000269|PubMed:15817151, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:23251453}.		intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15781635, ECO:0000269|PubMed:16354688}. Cytoplasm {ECO:0000269|PubMed:15781635}. Note=Also cytoplasmic in cells grown at high densities.
Q86T26	reviewed	TM11B_HUMAN	Transmembrane protease serine 11B (EC 3.4.21.-) (Airway trypsin-like protease 5)	TMPRSS11B HATL5	Homo sapiens (Human)	416	FUNCTION: Serine protease. {ECO:0000269|PubMed:24498351}.		proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24498351}; Single-pass type II membrane protein {ECO:0000305}.
Q86T65	reviewed	DAAM2_HUMAN	Disheveled-associated activator of morphogenesis 2	DAAM2 KIAA0381	Homo sapiens (Human)	1068	FUNCTION: Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration (PubMed:33232676). {ECO:0000250|UniProtKB:Q80U19, ECO:0000269|PubMed:33232676}.		actin cytoskeleton organization [GO:0030036]; determination of left/right symmetry [GO:0007368]; dorsal spinal cord development [GO:0021516]; negative regulation of oligodendrocyte differentiation [GO:0048715]; podocyte cell migration [GO:0090521]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of filopodium assembly [GO:0051489]; regulation of non-canonical Wnt signaling pathway [GO:2000050]; Wnt signaling pathway [GO:0016055]	extracellular exosome [GO:0070062]	actin binding [GO:0003779]; small GTPase binding [GO:0031267]	extracellular exosome [GO:0070062]; actin binding [GO:0003779]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; determination of left/right symmetry [GO:0007368]; dorsal spinal cord development [GO:0021516]; negative regulation of oligodendrocyte differentiation [GO:0048715]; podocyte cell migration [GO:0090521]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of filopodium assembly [GO:0051489]; regulation of non-canonical Wnt signaling pathway [GO:2000050]; Wnt signaling pathway [GO:0016055]	
Q86T82	reviewed	UBP37_HUMAN	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37)	USP37 KIAA1594	Homo sapiens (Human)	979	FUNCTION: Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response (PubMed:26299517, PubMed:27296872, PubMed:31911859, PubMed:34509474). Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). Plays also an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability (PubMed:34509474). Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM (PubMed:34606619). Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM (PubMed:34606619). Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI (PubMed:31911859). Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination (PubMed:26299517). {ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:26299517, ECO:0000269|PubMed:27296872, ECO:0000269|PubMed:31911859, ECO:0000269|PubMed:34509474, ECO:0000269|PubMed:34606619}.		cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; regulation of DNA replication [GO:0006275]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; protein kinase binding [GO:0019901]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; protein kinase binding [GO:0019901]; cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; regulation of DNA replication [GO:0006275]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26299517}. Chromosome {ECO:0000269|PubMed:26299517}.
Q86T90	reviewed	K1328_HUMAN	Protein hinderin	KIAA1328	Homo sapiens (Human)	577	FUNCTION: Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}.						
Q86T96	reviewed	RN180_HUMAN	E3 ubiquitin-protein ligase RNF180 (EC 2.3.2.27) (RING finger protein 180) (RING-type E3 ubiquitin transferase RNF180)	RNF180	Homo sapiens (Human)	592	FUNCTION: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. {ECO:0000250|UniProtKB:Q3U827}.		adult behavior [GO:0030534]; norepinephrine metabolic process [GO:0042415]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; serotonin metabolic process [GO:0042428]	endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]	metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; adult behavior [GO:0030534]; norepinephrine metabolic process [GO:0042415]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; serotonin metabolic process [GO:0042428]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope {ECO:0000250|UniProtKB:Q3U827}.
Q86TB3	reviewed	ALPK2_HUMAN	Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase)	ALPK2 HAK	Homo sapiens (Human)	2170	FUNCTION: Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752). {ECO:0000269|PubMed:29888752, ECO:0000303|PubMed:10021370}.		cardiac muscle cell development [GO:0055013]; epicardium morphogenesis [GO:1905223]; establishment of cell polarity [GO:0030010]; heart morphogenesis [GO:0003007]; negative regulation of Wnt signaling pathway involved in heart development [GO:0003308]; phosphorylation [GO:0016310]; regulation of apoptotic process [GO:0042981]; regulation of gene expression [GO:0010468]	basolateral plasma membrane [GO:0016323]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	basolateral plasma membrane [GO:0016323]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cardiac muscle cell development [GO:0055013]; epicardium morphogenesis [GO:1905223]; establishment of cell polarity [GO:0030010]; heart morphogenesis [GO:0003007]; negative regulation of Wnt signaling pathway involved in heart development [GO:0003308]; phosphorylation [GO:0016310]; regulation of apoptotic process [GO:0042981]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:28668886}.
Q86TB9	reviewed	PATL1_HUMAN	Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b)	PATL1 OK/KNS-cl.5	Homo sapiens (Human)	770	FUNCTION: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}.		deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; P-body assembly [GO:0033962]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; P-body [GO:0000932]; PML body [GO:0016605]	poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; P-body [GO:0000932]; PML body [GO:0016605]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; P-body assembly [GO:0033962]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20826699, ECO:0000269|PubMed:20852261, ECO:0000269|PubMed:22090346, ECO:0000269|PubMed:32354837}. Nucleus {ECO:0000269|PubMed:22090346}. Nucleus, PML body {ECO:0000269|PubMed:22090346}. Nucleus speckle {ECO:0000269|PubMed:22090346}. Note=Predominantly cytoplasmic (PubMed:22090346). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:22090346). Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus (PubMed:22090346). {ECO:0000269|PubMed:22090346}.
Q86TC9	reviewed	MYPN_HUMAN	Myopalladin (145 kDa sarcomeric protein)	MYPN MYOP	Homo sapiens (Human)	1320	FUNCTION: Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}.		axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; sarcomere organization [GO:0045214]	axon [GO:0030424]; cytosol [GO:0005829]; I band [GO:0031674]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Z disc [GO:0030018]	actin binding [GO:0003779]; cell-cell adhesion mediator activity [GO:0098632]; cytoskeletal protein binding [GO:0008092]; muscle alpha-actinin binding [GO:0051371]; SH3 domain binding [GO:0017124]	axon [GO:0030424]; cytosol [GO:0005829]; I band [GO:0031674]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Z disc [GO:0030018]; actin binding [GO:0003779]; cell-cell adhesion mediator activity [GO:0098632]; cytoskeletal protein binding [GO:0008092]; muscle alpha-actinin binding [GO:0051371]; SH3 domain binding [GO:0017124]; axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; sarcomere organization [GO:0045214]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11309420}. Nucleus {ECO:0000269|PubMed:11309420}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:11309420}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11309420, ECO:0000269|PubMed:28017374}. Note=Bound to sarcomere both at the Z-line periphery and in the central I-band region. {ECO:0000269|PubMed:11309420}.
Q86TG1	reviewed	T150A_HUMAN	Transmembrane protein 150A (Transmembrane protein 150)	TMEM150A TMEM150	Homo sapiens (Human)	271	FUNCTION: Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also play a role in fasting-induced catabolism (By similarity). {ECO:0000250|UniProtKB:Q9QZE9, ECO:0000269|PubMed:25608530}.		catabolic process [GO:0009056]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; catabolic process [GO:0009056]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25608530}; Multi-pass membrane protein {ECO:0000269|PubMed:25608530}. Note=Localizes mainly at the plasma membrane; only a minor fraction localizes on intracellular structures (PubMed:25608530). {ECO:0000269|PubMed:25608530}.
Q86TG7	reviewed	PEG10_HUMAN	Retrotransposon-derived protein PEG10 (Embryonal carcinoma differentiation-regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein)	PEG10 EDR KIAA1051e MAR2 MART2 MEF3L1 RGAG3	Homo sapiens (Human)	708	FUNCTION: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity). {ECO:0000250|UniProtKB:Q7TN75, ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:15611116, ECO:0000269|PubMed:16423995, ECO:0000269|PubMed:26235627, ECO:0000269|PubMed:28193232, ECO:0000269|PubMed:30094509, ECO:0000269|PubMed:34413232}.	MISCELLANEOUS: The PEG10 locus is imprinted, giving rise to paternally expressed proteins. {ECO:0000269|PubMed:11318613}.; MISCELLANEOUS: [Isoform 1]: Produced by a -1 ribosomal frameshifting due to a slippery site occurring between the codons for Gly-319 and Lys-320 (PubMed:17942406). The ribosomal frameshifting efficiency yield up to 66% of isoform 1 compared to isoform 2 (PubMed:17942406). {ECO:0000269|PubMed:17942406}.; MISCELLANEOUS: [Isoform 2]: Produced by conventional translation. {ECO:0000269|PubMed:17942406}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation (PubMed:20084274). Translation initiates from a non-AUG codon (CUG codon) (PubMed:20084274). {ECO:0000269|PubMed:20084274}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative initiation and ribosomal frameshifting (PubMed:20084274). Produced by a -1 ribosomal frameshifting due to a slippery site occurring between the codons for Gly-395 and Lys-396 (PubMed:20084274). Translation initiates from a non-AUG codon (CUG codon) (PubMed:20084274). {ECO:0000269|PubMed:20084274}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative initiation (Probable). Translation initiates from a non-AUG codon (CUG codon) (Probable). {ECO:0000305}.	apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; mRNA transport [GO:0051028]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein homooligomerization [GO:0051260]; vesicle-mediated intercellular transport [GO:0110077]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; mRNA transport [GO:0051028]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein homooligomerization [GO:0051260]; vesicle-mediated intercellular transport [GO:0110077]	SUBCELLULAR LOCATION: Extracellular vesicle membrane {ECO:0000269|PubMed:34413232}. Cytoplasm {ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:15611116, ECO:0000269|PubMed:16423995, ECO:0000269|PubMed:17621626}. Nucleus {ECO:0000269|PubMed:12810624}. Note=Forms virion-like extracellular vesicles that are released from cells (PubMed:34413232). Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line (PubMed:12810624). {ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:34413232}.
Q86TH1	reviewed	ATL2_HUMAN	ADAMTS-like protein 2 (ADAMTSL-2)	ADAMTSL2 KIAA0605	Homo sapiens (Human)	951		MISCELLANEOUS: There is a significant increase in total and active TGFB1 in the culture medium as well as nuclear localization of phosphorylated SMAD2 in fibroblasts from individuals with geleophysic dysplasia.	extracellular matrix organization [GO:0030198]; lobar bronchus epithelium development [GO:0060481]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	microfibril binding [GO:0050436]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril binding [GO:0050436]; extracellular matrix organization [GO:0030198]; lobar bronchus epithelium development [GO:0060481]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86TI0	reviewed	TBCD1_HUMAN	TBC1 domain family member 1	TBC1D1 KIAA1108	Homo sapiens (Human)	1168	FUNCTION: May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}.			nucleus [GO:0005634]	GTPase activator activity [GO:0005096]	nucleus [GO:0005634]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q86TI2	reviewed	DPP9_HUMAN	Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9)	DPP9 DPRP2	Homo sapiens (Human)	863	FUNCTION: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36357533). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:34019797, PubMed:33731929, PubMed:33731932). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929). {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:16475979, ECO:0000269|PubMed:19667070, ECO:0000269|PubMed:27820798, ECO:0000269|PubMed:29382749, ECO:0000269|PubMed:29967349, ECO:0000269|PubMed:30291141, ECO:0000269|PubMed:31525884, ECO:0000269|PubMed:32796818, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:34019797, ECO:0000269|PubMed:36357533}.	MISCELLANEOUS: [Isoform 2]: Active peptidase. Contains a nuclear localization signal at positions 2-9. {ECO:0000269|PubMed:24562348}.	negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]	cell leading edge [GO:0031252]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]	aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; serine-type peptidase activity [GO:0008236]	cell leading edge [GO:0031252]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; serine-type peptidase activity [GO:0008236]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:15245913}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:24562348}.
Q86TJ2	reviewed	TAD2B_HUMAN	Transcriptional adapter 2-beta (ADA2-like protein beta) (ADA2-beta)	TADA2B ADA2B	Homo sapiens (Human)	420	FUNCTION: Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. {ECO:0000269|PubMed:12972612}.		chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of histone acetylation [GO:0035065]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461]	chromatin binding [GO:0003682]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461]; chromatin binding [GO:0003682]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]; chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of histone acetylation [GO:0035065]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86TL0	reviewed	ATG4D_HUMAN	Cysteine protease ATG4D (EC 3.4.22.-) (AUT-like 4 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 4) (Autophagin-4) (Autophagy-related protein 4 homolog D) (HsAPG4D) [Cleaved into: Cysteine protease ATG4D, mitochondrial]	ATG4D APG4D AUTL4	Homo sapiens (Human)	474	FUNCTION: [Cysteine protease ATG4D]: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:21177865, PubMed:29458288, PubMed:30661429). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (PubMed:21177865). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:29458288, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:29458288, PubMed:33909989). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (PubMed:33909989). ATG4D plays a role in the autophagy-mediated neuronal homeostasis in the central nervous system (By similarity). Compared to other members of the family (ATG4A, ATG4B or ATG4C), constitutes the major protein for the delipidation activity, while it promotes weak proteolytic activation of ATG8 proteins (By similarity). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106). {ECO:0000250|UniProtKB:Q8BGV9, ECO:0000250|UniProtKB:Q9Y4P1, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}.; FUNCTION: [Cysteine protease ATG4D, mitochondrial]: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability. {ECO:0000269|PubMed:19549685, ECO:0000269|PubMed:22441018}.		apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; mitophagy [GO:0000423]; protein delipidation [GO:0051697]; protein localization to phagophore assembly site [GO:0034497]; protein transport [GO:0015031]; proteolysis [GO:0006508]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	cysteine-type exopeptidase activity [GO:0070004]; cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; cysteine-type exopeptidase activity [GO:0070004]; cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786]; apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; mitophagy [GO:0000423]; protein delipidation [GO:0051697]; protein localization to phagophore assembly site [GO:0034497]; protein transport [GO:0015031]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: [Cysteine protease ATG4D]: Cytoplasm {ECO:0000269|PubMed:19549685}.; SUBCELLULAR LOCATION: [Cysteine protease ATG4D, mitochondrial]: Cytoplasm {ECO:0000269|PubMed:19549685}. Mitochondrion matrix {ECO:0000269|PubMed:19549685, ECO:0000269|PubMed:22441018}. Note=Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death. {ECO:0000269|PubMed:22441018}.
Q86TL2	reviewed	STIMA_HUMAN	Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110)	STIMATE TMEM110	Homo sapiens (Human)	294	FUNCTION: Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574). {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}.		activation of store-operated calcium channel activity [GO:0032237]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]	cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]	calcium channel regulator activity [GO:0005246]	cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; calcium channel regulator activity [GO:0005246]; activation of store-operated calcium channel activity [GO:0032237]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}; Multi-pass membrane protein {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}. Note=Colocalizes with STIM1 at ER-plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells (PubMed:26644574). May translocate to ER-PM junctions in a STIM1-dependent manner in store-depleted cells (Probable). {ECO:0000269|PubMed:26644574, ECO:0000305|PubMed:26322679}.
Q86TM3	reviewed	DDX53_HUMAN	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.4.13) (Cancer-associated gene protein) (Cancer/testis antigen 26) (CT26) (DEAD box protein 53) (DEAD box protein CAGE)	DDX53 CAGE	Homo sapiens (Human)	631				cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11922625}.
Q86TM6	reviewed	SYVN1_HUMAN	E3 ubiquitin-protein ligase synoviolin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase synoviolin) (Synovial apoptosis inhibitor 1)	SYVN1 HRD1 KIAA1810	Homo sapiens (Human)	617	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28827405). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28842558). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity). During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY1, ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16289116, ECO:0000269|PubMed:16847254, ECO:0000269|PubMed:17059562, ECO:0000269|PubMed:17141218, ECO:0000269|PubMed:17170702, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:26471130, ECO:0000269|PubMed:28827405, ECO:0000269|PubMed:28842558}.		ERAD pathway [GO:0036503]; immature B cell differentiation [GO:0002327]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; protein K48-linked ubiquitination [GO:0070936]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Hrd1p ubiquitin ligase complex [GO:0000836]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; smooth endoplasmic reticulum [GO:0005790]	ATPase binding [GO:0051117]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-specific protease binding [GO:1990381]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Hrd1p ubiquitin ligase complex [GO:0000836]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; smooth endoplasmic reticulum [GO:0005790]; ATPase binding [GO:0051117]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-specific protease binding [GO:1990381]; unfolded protein binding [GO:0051082]; ERAD pathway [GO:0036503]; immature B cell differentiation [GO:0002327]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; protein K48-linked ubiquitination [GO:0070936]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:26471130}; Multi-pass membrane protein {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}.
Q86TP1	reviewed	PRUN1_HUMAN	Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune)	PRUNE1 PRUNE	Homo sapiens (Human)	453	FUNCTION: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697, ECO:0000269|PubMed:28334956}.		regulation of microtubule polymerization [GO:0031113]; regulation of neurogenesis [GO:0050767]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]	exopolyphosphatase activity [GO:0004309]; inorganic diphosphate phosphatase activity [GO:0004427]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; exopolyphosphatase activity [GO:0004309]; inorganic diphosphate phosphatase activity [GO:0004427]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; tubulin binding [GO:0015631]; regulation of microtubule polymerization [GO:0031113]; regulation of neurogenesis [GO:0050767]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
Q86TS9	reviewed	RM52_HUMAN	Large ribosomal subunit protein mL52 (39S ribosomal protein L52, mitochondrial) (L52mt) (MRP-L52)	MRPL52	Homo sapiens (Human)	123			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:28892042}.
Q86TU7	reviewed	SETD3_HUMAN	Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3)	SETD3 C14orf154	Homo sapiens (Human)	594	FUNCTION: Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}.	MISCELLANEOUS: Shows protein-methionine methyltransferase activity in vitro on an actin mutant with a Met instead of a His residue at position 73. {ECO:0000269|PubMed:32503840}.	actin modification [GO:0030047]; peptidyl-histidine methylation [GO:0018021]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of uterine smooth muscle contraction [GO:0070472]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	actin binding [GO:0003779]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; protein-L-histidine N-tele-methyltransferase activity [GO:0018064]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; actin binding [GO:0003779]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; protein-L-histidine N-tele-methyltransferase activity [GO:0018064]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; actin modification [GO:0030047]; peptidyl-histidine methylation [GO:0018021]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of uterine smooth muscle contraction [GO:0070472]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28442573, ECO:0000269|PubMed:30626964}. Nucleus {ECO:0000269|PubMed:28442573}. Note=Localizes mainly in the cytoplasm. {ECO:0000269|PubMed:28442573}.
Q86TV6	reviewed	TTC7B_HUMAN	Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1)	TTC7B TTC7L1	Homo sapiens (Human)	843	FUNCTION: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:26571211}.		phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	cytosol [GO:0005829]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; plasma membrane [GO:0005886]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23229899}. Cell membrane {ECO:0000269|PubMed:23229899}. Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with EFR3 (EFR3A or EFR3B) (PubMed:23229899). {ECO:0000269|PubMed:23229899}.
Q86TW2	reviewed	ADCK1_HUMAN	AarF domain-containing protein kinase 1 (EC 2.7.-.-)	ADCK1	Homo sapiens (Human)	530	FUNCTION: Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (PubMed:31125351). The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). {ECO:0000269|PubMed:31125351, ECO:0000305}.		lipid homeostasis [GO:0055088]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial fusion [GO:0010637]; phosphorylation [GO:0016310]; positive regulation of cristae formation [GO:1903852]	extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]	ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]	extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; lipid homeostasis [GO:0055088]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial fusion [GO:0010637]; phosphorylation [GO:0016310]; positive regulation of cristae formation [GO:1903852]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86TX2	reviewed	ACOT1_HUMAN	Acyl-coenzyme A thioesterase 1 (Acyl-CoA thioesterase 1) (EC 3.1.2.-) (CTE-I) (CTE-Ib) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (Palmitoyl-coenzyme A thioesterase) (EC 3.1.2.2)	ACOT1 CTE1	Homo sapiens (Human)	421	FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20). {ECO:0000269|PubMed:16940157}.		acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid metabolic process [GO:0001676]; very long-chain fatty acid metabolic process [GO:0000038]	cytosol [GO:0005829]	acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]	cytosol [GO:0005829]; acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid metabolic process [GO:0001676]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16940157}.
Q86TY3	reviewed	ARMD4_HUMAN	Armadillo-like helical domain-containing protein 4 (Upstream of mTORC2 protein)	ARMH4 C14orf37	Homo sapiens (Human)	774	FUNCTION: May modulate immune response and may play a role in inflammation (PubMed:36649229). Down-modulates STAT3 signaling throught direct interaction with IL6ST, resulting in the inhibition of phosphorylation of STAT3 at 'Tyr-705' (PubMed:26927669). May negatively regulates AKT signaling by modulating the activity of mTORC2 complex through RICTOR interaction (By similarity). {ECO:0000250|UniProtKB:Q8BT18, ECO:0000269|PubMed:26927669, ECO:0000269|PubMed:36649229}.		regulation of inflammatory response [GO:0050727]; regulation of TORC2 signaling [GO:1903939]	membrane [GO:0016020]	TORC2 complex binding [GO:1904841]	membrane [GO:0016020]; TORC2 complex binding [GO:1904841]; regulation of inflammatory response [GO:0050727]; regulation of TORC2 signaling [GO:1903939]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:36649229}; Single-pass type I membrane protein {ECO:0000305}.
Q86U06	reviewed	RBM23_HUMAN	Probable RNA-binding protein 23 (CAPER beta) (CAPERbeta) (RNA-binding motif protein 23) (RNA-binding region-containing protein 4) (Splicing factor SF2)	RBM23 RNPC4 PP239	Homo sapiens (Human)	439	FUNCTION: RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343). {ECO:0000269|PubMed:15694343}.		mRNA processing [GO:0006397]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]	membrane [GO:0016020]; nucleus [GO:0005634]	RNA binding [GO:0003723]; U1 snRNP binding [GO:1990446]	membrane [GO:0016020]; nucleus [GO:0005634]; RNA binding [GO:0003723]; U1 snRNP binding [GO:1990446]; mRNA processing [GO:0006397]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86U10	reviewed	LPP60_HUMAN	60 kDa lysophospholipase (LysoLP) (EC 3.1.1.5) (Lysophospholipase-transacylase) [Includes: L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase); 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase)]	ASPG C14orf76	Homo sapiens (Human)	573	FUNCTION: Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (By similarity). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (By similarity). {ECO:0000250|UniProtKB:O88202}.	MISCELLANEOUS: [Isoform 3]: May be due to a competing acceptor splice site. {ECO:0000305}.	aspartate family amino acid metabolic process [GO:0009066]; lipid catabolic process [GO:0016042]	cytosol [GO:0005829]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; asparaginase activity [GO:0004067]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]	cytosol [GO:0005829]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; asparaginase activity [GO:0004067]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; aspartate family amino acid metabolic process [GO:0009066]; lipid catabolic process [GO:0016042]	
Q86U28	reviewed	ISCA2_HUMAN	Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1)	ISCA2 HBLD1	Homo sapiens (Human)	154	FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. {ECO:0000269|PubMed:22323289}.		iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22323289}.
Q86U42	reviewed	PABP2_HUMAN	Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)	PABPN1 PAB2 PABP2	Homo sapiens (Human)	306	FUNCTION: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). {ECO:0000250|UniProtKB:Q28165, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:27871484}.	MISCELLANEOUS: The association of the expanded polyalanine mutations together with the capability to oligomerize may induce intranuclear inclusions and cell death. Expanded polyalanine mutations may either result from unequal crossing over during germ cell homologous recombination or from DNA slippage. The pathogenic mechanisms mediated by polyalanine expansion mutations may be either a general disruption of cellular RNA metabolism due to the trapping by the inclusions of PABPN1, mRNAs and/or nuclear proteins, resulting in the induction of cell death; or may change the normal muscle cell differentiation. {ECO:0000269|PubMed:11689481}.; MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site. {ECO:0000305}.	cellular response to lipopolysaccharide [GO:0071222]; MAPK cascade [GO:0000165]; mRNA processing [GO:0006397]; muscle contraction [GO:0006936]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of polynucleotide adenylyltransferase activity [GO:1904247]; RNA processing [GO:0006396]	cytoplasm [GO:0005737]; nuclear inclusion body [GO:0042405]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]	cytoplasm [GO:0005737]; nuclear inclusion body [GO:0042405]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; cellular response to lipopolysaccharide [GO:0071222]; MAPK cascade [GO:0000165]; mRNA processing [GO:0006397]; muscle contraction [GO:0006936]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of polynucleotide adenylyltransferase activity [GO:1904247]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10688363, ECO:0000269|PubMed:11001936, ECO:0000269|PubMed:14663186, ECO:0000269|PubMed:27209344}. Cytoplasm {ECO:0000269|PubMed:10688363, ECO:0000269|PubMed:11001936, ECO:0000269|PubMed:14663186, ECO:0000269|PubMed:17289661}. Nucleus speckle {ECO:0000269|PubMed:10688363, ECO:0000269|PubMed:11371506}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus (PubMed:10688363). Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism (By similarity). Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). Intranuclear filamentous inclusions or 'aggregates' are detected in the myocytes of patients; these inclusions contain PABPN1, ubiquitin, subunits of the proteasome and poly(A) RNA. {ECO:0000250|UniProtKB:Q28165, ECO:0000269|PubMed:10688363, ECO:0000269|PubMed:11001936, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:14663186, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:27209344}.
Q86U44	reviewed	MTA70_HUMAN	N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70)	METTL3 MTA70	Homo sapiens (Human)	580	FUNCTION: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:28297716, PubMed:30428350, PubMed:29506078, PubMed:29348140, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronorivus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}.		adenosine to inosine editing [GO:0006382]; cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; dosage compensation by inactivation of X chromosome [GO:0009048]; endothelial to hematopoietic transition [GO:0098508]; forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; innate immune response [GO:0045087]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; oogenesis [GO:0048477]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of translation [GO:0045727]; primary miRNA processing [GO:0031053]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of meiotic cell cycle [GO:0051445]; regulation of T cell differentiation [GO:0045580]; RNA methylation [GO:0001510]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity [GO:0016422]; mRNA (N6-adenosine)-methyltransferase activity [GO:0001734]; mRNA binding [GO:0003729]; protein heterodimerization activity [GO:0046982]; RNA methyltransferase activity [GO:0008173]; S-adenosyl-L-methionine binding [GO:1904047]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity [GO:0016422]; mRNA (N6-adenosine)-methyltransferase activity [GO:0001734]; mRNA binding [GO:0003729]; protein heterodimerization activity [GO:0046982]; RNA methyltransferase activity [GO:0008173]; S-adenosyl-L-methionine binding [GO:1904047]; adenosine to inosine editing [GO:0006382]; cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; dosage compensation by inactivation of X chromosome [GO:0009048]; endothelial to hematopoietic transition [GO:0098508]; forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; innate immune response [GO:0045087]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; oogenesis [GO:0048477]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of translation [GO:0045727]; primary miRNA processing [GO:0031053]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of meiotic cell cycle [GO:0051445]; regulation of T cell differentiation [GO:0045580]; RNA methylation [GO:0001510]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078}. Nucleus speckle {ECO:0000269|PubMed:9409616}. Cytoplasm {ECO:0000269|PubMed:27117702}. Note=Colocalizes with speckles in interphase nuclei, suggesting that it may be associated with nuclear pre-mRNA splicing components (PubMed:9409616). In response to ultraviolet irradiation, colocalizes to DNA damage sites however, it probably does not bind DNA but localizes in the vicinity of DNA damage sites (PubMed:28297716). {ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:9409616}.
Q86U70	reviewed	LDB1_HUMAN	LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)	LDB1 CLIM2	Homo sapiens (Human)	411	FUNCTION: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}.	MISCELLANEOUS: Acts as a negative coregulator of ESR1-mediated transcription in breast cancer cells.; MISCELLANEOUS: [Isoform 2]: Due to intron retention. Lacks LIM-binding domain. {ECO:0000305}.	anterior/posterior axis specification [GO:0009948]; cell adhesion [GO:0007155]; cellular component assembly [GO:0022607]; cerebellar Purkinje cell differentiation [GO:0021702]; epithelial structure maintenance [GO:0010669]; gastrulation with mouth forming second [GO:0001702]; hair follicle development [GO:0001942]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; positive regulation of cell adhesion [GO:0045785]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of kinase activity [GO:0043549]; somatic stem cell population maintenance [GO:0035019]; transcription by RNA polymerase II [GO:0006366]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]; Wnt signaling pathway [GO:0016055]	beta-catenin-TCF complex [GO:1990907]; cell leading edge [GO:0031252]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; LIM domain binding [GO:0030274]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]	beta-catenin-TCF complex [GO:1990907]; cell leading edge [GO:0031252]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; LIM domain binding [GO:0030274]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; anterior/posterior axis specification [GO:0009948]; cell adhesion [GO:0007155]; cellular component assembly [GO:0022607]; cerebellar Purkinje cell differentiation [GO:0021702]; epithelial structure maintenance [GO:0010669]; gastrulation with mouth forming second [GO:0001702]; hair follicle development [GO:0001942]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; positive regulation of cell adhesion [GO:0045785]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of kinase activity [GO:0043549]; somatic stem cell population maintenance [GO:0035019]; transcription by RNA polymerase II [GO:0006366]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P70662}. Note=Colocalizes with SLK at leading edges. {ECO:0000250|UniProtKB:P70662}.
Q86U86	reviewed	PB1_HUMAN	Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D)	PBRM1 BAF180 PB1	Homo sapiens (Human)	1689	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.		chromatin remodeling [GO:0006338]; mitotic cell cycle [GO:0000278]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]	chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]	chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; chromatin remodeling [GO:0006338]; mitotic cell cycle [GO:0000278]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q86U90	reviewed	YRDC_HUMAN	Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP)	YRDC DRIP3 IRIP	Homo sapiens (Human)	279	FUNCTION: Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:29760464, PubMed:31481669, PubMed:34545459). Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate (PubMed:29760464). Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (PubMed:29760464). May regulate the activity of some transporters (By similarity). {ECO:0000250|UniProtKB:Q3U5F4, ECO:0000269|PubMed:29760464, ECO:0000269|PubMed:31481669, ECO:0000269|PubMed:34545459}.		negative regulation of transport [GO:0051051]; regulation of translational fidelity [GO:0006450]; tRNA threonylcarbamoyladenosine modification [GO:0002949]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	double-stranded RNA binding [GO:0003725]; L-threonylcarbamoyladenylate synthase [GO:0061710]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; double-stranded RNA binding [GO:0003725]; L-threonylcarbamoyladenylate synthase [GO:0061710]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]; negative regulation of transport [GO:0051051]; regulation of translational fidelity [GO:0006450]; tRNA threonylcarbamoyladenosine modification [GO:0002949]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29760464}. Mitochondrion {ECO:0000269|PubMed:29760464}. Cell membrane {ECO:0000250|UniProtKB:Q3U5F4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3U5F4}. Note=A large fraction localizes in the cytoplasm, whereas a smaller fraction is imported to mitochondria. {ECO:0000269|PubMed:29760464}.
Q86UA6	reviewed	RIP_HUMAN	RPA-interacting protein (hRIP)	RPAIN RIP	Homo sapiens (Human)	219	FUNCTION: Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. {ECO:0000269|PubMed:16135809}.	MISCELLANEOUS: [Isoform 1]: Major isoform with isoform 2.; MISCELLANEOUS: [Isoform 2]: Major isoform with isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. May be due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	protein import into nucleus [GO:0006606]; response to UV [GO:0009411]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; metal ion binding [GO:0046872]; protein import into nucleus [GO:0006606]; response to UV [GO:0009411]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, PML body.
Q86UC2	reviewed	RSPH3_HUMAN	Radial spoke head protein 3 homolog (A-kinase anchor protein RSPH3) (Radial spoke head-like protein 2)	RSPH3 RSHL2 RSP3	Homo sapiens (Human)	560	FUNCTION: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (By similarity). Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (PubMed:19684019). {ECO:0000250|UniProtKB:Q9DA80, ECO:0000269|PubMed:19684019}.			cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]		cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:27120127}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000305}.
Q86UD0	reviewed	SAPC2_HUMAN	Suppressor APC domain-containing protein 2 (Tumor specificity and mitosis phase-dependent expression protein) (TS/MDEP) (p42.3)	SAPCD2 C9orf140	Homo sapiens (Human)	394	FUNCTION: Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). {ECO:0000250|UniProtKB:Q9D818, ECO:0000269|PubMed:23576022, ECO:0000269|PubMed:23704824, ECO:0000269|PubMed:26766442}.		establishment of mitotic spindle orientation [GO:0000132]; negative regulation of protein localization to cell cortex [GO:1904777]; positive regulation of cell population proliferation [GO:0008284]; regulation of establishment of planar polarity [GO:0090175]; symmetric cell division [GO:0098725]	apical cortex [GO:0045179]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		apical cortex [GO:0045179]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; establishment of mitotic spindle orientation [GO:0000132]; negative regulation of protein localization to cell cortex [GO:1904777]; positive regulation of cell population proliferation [GO:0008284]; regulation of establishment of planar polarity [GO:0090175]; symmetric cell division [GO:0098725]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17525738}. Nucleus {ECO:0000269|PubMed:17525738}. Cytoplasm, cell cortex {ECO:0000269|PubMed:26766442}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D818}. Cell junction, tight junction {ECO:0000269|PubMed:26766442}. Note=Localized at the apical cortical region during the M phase. In horizontally retinal progenitor dividing cells, localized at the pole cortical region from prophase to telophase cells. In vertically retinal progenitor dividing cells, not detected at the pole cortical region at any stage of mitosis. {ECO:0000250|UniProtKB:Q9D818}.
Q86UD3	reviewed	MARH3_HUMAN	E3 ubiquitin-protein ligase MARCHF3 (EC 2.3.2.27) (Membrane-associated RING finger protein 3) (Membrane-associated RING-CH protein III) (MARCH-III) (RING finger protein 173) (RING-type E3 ubiquitin transferase MARCHF3)	MARCHF3 MARCH3 RNF173	Homo sapiens (Human)	253	FUNCTION: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000250|UniProtKB:Q5XIE5}.		endocytosis [GO:0006897]; protein ubiquitination [GO:0016567]	early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]	ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; endocytosis [GO:0006897]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16428329}; Multi-pass membrane protein {ECO:0000269|PubMed:16428329}. Early endosome membrane {ECO:0000269|PubMed:16428329}; Multi-pass membrane protein {ECO:0000269|PubMed:16428329}.
Q86UD4	reviewed	ZN329_HUMAN	Zinc finger protein 329	ZNF329	Homo sapiens (Human)	541	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86UD5	reviewed	SL9B2_HUMAN	Sodium/hydrogen exchanger 9B2 (Na(+)/H(+) exchanger NHA2) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Sodium/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2)	SLC9B2 NHA2 NHEDC2	Homo sapiens (Human)	537	FUNCTION: Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966, PubMed:36177733). Uses the proton gradient/membrane potential to extrude sodium (PubMed:22948142). Contributes to the regulation of intracellular pH and sodium homeostasis (By similarity). Also able to mediate Na(+)/Li(+) antiporter activity in kidney (PubMed:22948142). May play a physiological role in renal tubular function and blood pressure homeostasis (By similarity). Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity). {ECO:0000250|UniProtKB:Q5BKR2, ECO:0000269|PubMed:18000046, ECO:0000269|PubMed:18508966, ECO:0000269|PubMed:22948142, ECO:0000269|PubMed:28154142, ECO:0000269|PubMed:36177733}.	MISCELLANEOUS: The subcellular localization of SLC9B2 remains controversial. Was initially thought to partially localize to mitochondria (By similarity). However SLC9B2 does not seem to contain a mitochondrial targeting sequence. It was later established that its localizes predominantly in plasma membrane or intracellularly to endosomes and lysosomes (By similarity). In another recent study, endogenous SLC9B2 in the distal tubular cell line mpkDCT4 is detected in recycling endosomes but absent in plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q5BKR2}.	clathrin-dependent endocytosis [GO:0072583]; flagellated sperm motility [GO:0030317]; lithium ion transport [GO:0010351]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of osteoclast development [GO:2001206]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; sodium ion homeostasis [GO:0055078]; sodium ion transport [GO:0006814]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; sperm principal piece [GO:0097228]; synaptic vesicle membrane [GO:0030672]	identical protein binding [GO:0042802]; lithium:proton antiporter activity [GO:0010348]; sodium:proton antiporter activity [GO:0015385]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; sperm principal piece [GO:0097228]; synaptic vesicle membrane [GO:0030672]; identical protein binding [GO:0042802]; lithium:proton antiporter activity [GO:0010348]; sodium:proton antiporter activity [GO:0015385]; clathrin-dependent endocytosis [GO:0072583]; flagellated sperm motility [GO:0030317]; lithium ion transport [GO:0010351]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of osteoclast development [GO:2001206]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; sodium ion homeostasis [GO:0055078]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18000046, ECO:0000269|PubMed:36177733}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Endosome membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Apical cell membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Note=Strong colocalization with LAMP1 and TCIRG1 in osteoclasts. In beta-cells colocalizes with RAB4A and SYP. Localizes to the basolateral membrane of polarized osteoclasts. {ECO:0000250|UniProtKB:Q5BKR2}.
Q86UE4	reviewed	LYRIC_HUMAN	Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein)	MTDH AEG1 LYRIC	Homo sapiens (Human)	582	FUNCTION: Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}.	MISCELLANEOUS: Knockdown significantly reduces the adhesion of cancer cells to lung microvascular endothelial cells and the reciprocal effect is observed following overexpression.	lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of transcription by RNA polymerase II [GO:0006357]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fibrillar center [GO:0001650]; intercellular canaliculus [GO:0046581]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	double-stranded RNA binding [GO:0003725]; NF-kappaB binding [GO:0051059]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fibrillar center [GO:0001650]; intercellular canaliculus [GO:0046581]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; double-stranded RNA binding [GO:0003725]; NF-kappaB binding [GO:0051059]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus. {ECO:0000250}.
Q86UE6	reviewed	LRRT1_HUMAN	Leucine-rich repeat transmembrane neuronal protein 1	LRRTM1 UNQ675/PRO1309	Homo sapiens (Human)	522	FUNCTION: Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level. {ECO:0000250}.	MISCELLANEOUS: This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated paternally with handedness and schizophrenia.	establishment of localization in cell [GO:0051649]; exploration behavior [GO:0035640]; locomotory behavior [GO:0007626]; long-term synaptic potentiation [GO:0060291]; negative regulation of receptor internalization [GO:0002091]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; receptor internalization [GO:0031623]; synapse organization [GO:0050808]	axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; growth cone [GO:0030426]; postsynaptic specialization membrane [GO:0099634]		axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; growth cone [GO:0030426]; postsynaptic specialization membrane [GO:0099634]; establishment of localization in cell [GO:0051649]; exploration behavior [GO:0035640]; locomotory behavior [GO:0007626]; long-term synaptic potentiation [GO:0060291]; negative regulation of receptor internalization [GO:0002091]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; receptor internalization [GO:0031623]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q86UE8	reviewed	TLK2_HUMAN	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2)	TLK2	Homo sapiens (Human)	772	FUNCTION: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:9427565, PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}.		cellular response to gamma radiation [GO:0071480]; chromatin organization [GO:0006325]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; negative regulation of autophagy [GO:0010507]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; nucleus localization [GO:0051647]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of chromatin organization [GO:1902275]	intermediate filament [GO:0005882]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	intermediate filament [GO:0005882]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cellular response to gamma radiation [GO:0071480]; chromatin organization [GO:0006325]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; negative regulation of autophagy [GO:0010507]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; nucleus localization [GO:0051647]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of chromatin organization [GO:1902275]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10455159, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:9427565}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:33323470}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10455159, ECO:0000269|PubMed:33323470}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10455159}. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle (PubMed:10455159). Present in the perinuclear region at S phase and in the nucleus at late G2 (PubMed:10455159). {ECO:0000269|PubMed:10455159}.
Q86UF1	reviewed	TSN33_HUMAN	Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane)	TSPAN33 PEN	Homo sapiens (Human)	283	FUNCTION: Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011). {ECO:0000250|UniProtKB:Q8R3S2, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:30463011}.		pore complex assembly [GO:0046931]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]	adherens junction [GO:0005912]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; tetraspanin-enriched microdomain [GO:0097197]	enzyme binding [GO:0019899]	adherens junction [GO:0005912]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; tetraspanin-enriched microdomain [GO:0097197]; enzyme binding [GO:0019899]; pore complex assembly [GO:0046931]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862}; Multi-pass membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Cytoplasm {ECO:0000269|PubMed:30463011}. Note=Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction. {ECO:0000269|PubMed:30463011}.
Q86UG4	reviewed	SO6A1_HUMAN	Solute carrier organic anion transporter family member 6A1 (Cancer/testis antigen 48) (CT48) (Gonad-specific transporter) (GST) (Organic anion-transporting polypeptide 6A1) (Organic anion-transporting polypeptide I) (OATP-I) (Solute carrier family 21 member 19)	SLCO6A1 OATP6A1 SLC21A19	Homo sapiens (Human)	719			sodium-independent organic anion transport [GO:0043252]	plasma membrane [GO:0005886]	sodium-independent organic anion transmembrane transporter activity [GO:0015347]	plasma membrane [GO:0005886]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; sodium-independent organic anion transport [GO:0043252]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q86UK0	reviewed	ABCAC_HUMAN	Glucosylceramide transporter ABCA12 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 12) (ATP-binding cassette transporter 12) (ATP-binding cassette 12)	ABCA12 ABC12	Homo sapiens (Human)	2595	FUNCTION: Transports lipids such as glucosylceramides from the outer to the inner leaflet of lamellar granules (LGs) membrane, whereby the lipids are finally transported to the keratinocyte periphery via the trans-Golgi network and LGs and released to the apical surface of the granular keratinocytes to form lipid lamellae in the stratum corneum of the epidermis, which is essential for skin barrier function (PubMed:16007253, PubMed:20869849). In the meantime, participates in the transport of the lamellar granules-associated proteolytic enzymes, in turn regulates desquamation and keratinocyte differentiation (PubMed:19179616). Furthermore, is essential for the regulation of cellular cholesterol homeostasis by regulating ABCA1-dependent cholesterol efflux from macrophages through interaction with NR1H2 and ABCA1 (By similarity). Plays pleiotropic roles in regulating glucose stimulated insulin secretion from beta cells, regulating the morphology and fusion of insulin granules, lipid raft abundance and the actin cytoskeleton (By similarity). Also involved in lung surfactant biogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q876, ECO:0000269|PubMed:16007253, ECO:0000269|PubMed:19179616, ECO:0000269|PubMed:20869849}.		cellular homeostasis [GO:0019725]; ceramide metabolic process [GO:0006672]; ceramide transport [GO:0035627]; cholesterol efflux [GO:0033344]; corneocyte desquamation [GO:0003336]; establishment of skin barrier [GO:0061436]; intracellular protein transport [GO:0006886]; keratinization [GO:0031424]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; lung alveolus development [GO:0048286]; phospholipid efflux [GO:0033700]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of intracellular lipid transport [GO:0032379]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to plasma membrane [GO:0072659]; regulated exocytosis [GO:0045055]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of keratinocyte differentiation [GO:0045616]; secretion by cell [GO:0032940]; surfactant homeostasis [GO:0043129]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; epidermal lamellar body [GO:0097209]; epidermal lamellar body membrane [GO:0097234]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]	ABC-type transporter activity [GO:0140359]; apolipoprotein A-I receptor binding [GO:0034191]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; epidermal lamellar body [GO:0097209]; epidermal lamellar body membrane [GO:0097234]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]; ABC-type transporter activity [GO:0140359]; apolipoprotein A-I receptor binding [GO:0034191]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; signaling receptor binding [GO:0005102]; cellular homeostasis [GO:0019725]; ceramide metabolic process [GO:0006672]; ceramide transport [GO:0035627]; cholesterol efflux [GO:0033344]; corneocyte desquamation [GO:0003336]; establishment of skin barrier [GO:0061436]; intracellular protein transport [GO:0006886]; keratinization [GO:0031424]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; lung alveolus development [GO:0048286]; phospholipid efflux [GO:0033700]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of intracellular lipid transport [GO:0032379]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to plasma membrane [GO:0072659]; regulated exocytosis [GO:0045055]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of keratinocyte differentiation [GO:0045616]; secretion by cell [GO:0032940]; surfactant homeostasis [GO:0043129]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:16007253, ECO:0000269|PubMed:17927575}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:17927575}. Note=Localizes in the limiting membrane of the lamellar granules (LGs) (PubMed:17927575). Trafficks from the Golgi apparatus to the lamellar granules (LGs) at the cell periphery in the uppermost granular layer keratinocytes where ABCA12-positive LGs fuse with the keratinocyte-cell membrane to secrete their lipid content to the extracellular space of the stratum corneum (PubMed:16007253, PubMed:17927575). Co-localizes through the Golgi apparatus to the cell periphery with glucosylceramide (PubMed:17927575). {ECO:0000269|PubMed:16007253, ECO:0000269|PubMed:17927575}.
Q86UK5	reviewed	LBN_HUMAN	Limbin (Ellis-van Creveld syndrome protein 2) (EVC2)	EVC2 LBN	Homo sapiens (Human)	1308	FUNCTION: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis. {ECO:0000250|UniProtKB:Q8K1G2}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	smoothened signaling pathway [GO:0007224]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane protein complex [GO:0098797]		ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane protein complex [GO:0098797]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8K1G2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8K1G2}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8K1G2}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8K1G2}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q8K1G2}. Nucleus {ECO:0000250|UniProtKB:Q8K1G2}. Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner. {ECO:0000250|UniProtKB:Q8K1G2}.
Q86UK7	reviewed	ZN598_HUMAN	E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598)	ZNF598	Homo sapiens (Human)	904	FUNCTION: E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:32579943, PubMed:32099016, PubMed:33581075). ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs (PubMed:28065601, PubMed:28132843, PubMed:28685749). Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:30293783). Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10 (PubMed:28065601, PubMed:28132843, PubMed:28685749). Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides (PubMed:32579943, PubMed:32099016, PubMed:36302773). E3 ubiquitin-protein ligase activity is dependent on the E2 ubiquitin-conjugating enzyme UBE2D3 (PubMed:28685749). Also acts as an adapter that recruits the 4EHP-GYF2 complex to mRNAs (PubMed:22751931, PubMed:32726578). Independently of its role in RQC, may also act as a negative regulator of interferon-stimulated gene (ISG) expression (PubMed:29719242). {ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:28065601, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:28685749, ECO:0000269|PubMed:29719242, ECO:0000269|PubMed:30293783, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33581075, ECO:0000269|PubMed:36302773}.; FUNCTION: (Microbial infection) Required for poxvirus protein synthesis by mediating ubiquitination of RPS10/eS10 and RPS20/uS10 (PubMed:29719242). Poxvirus encoding mRNAs contain unusual 5' poly(A) leaders and ZNF598 is required for their translational efficiency, possibly via its ability to suppress readthrough or sliding on shorter poly(A) tracts (PubMed:29719242). {ECO:0000269|PubMed:29719242}.		negative regulation of translational initiation [GO:0045947]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]	metal ion binding [GO:0046872]; protein-RNA adaptor activity [GO:0140517]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; metal ion binding [GO:0046872]; protein-RNA adaptor activity [GO:0140517]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of translational initiation [GO:0045947]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:28757607}.
Q86UL3	reviewed	GPAT4_HUMAN	Glycerol-3-phosphate acyltransferase 4 (EC 2.3.1.15) (1-acylglycerol-3-phosphate O-acyltransferase 6) (1-AGP acyltransferase 6) (1-AGPAT 6) (Acyl-CoA:glycerol-3-phosphate acyltransferase 4) (Lysophosphatidic acid acyltransferase zeta) (LPAAT-zeta) (Testis spermatogenesis apoptosis-related protein 7) (TSARG7)	GPAT4 AGPAT6 TSARG7 UNQ551/PRO1108	Homo sapiens (Human)	456	FUNCTION: Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:18238778). Active against both saturated and unsaturated long-chain fatty acyl-CoAs (PubMed:18238778). Protects cells against lipotoxicity (PubMed:30846318). {ECO:0000269|PubMed:18238778, ECO:0000269|PubMed:30846318}.		acyl-CoA metabolic process [GO:0006637]; CDP-diacylglycerol biosynthetic process [GO:0016024]; diacylglycerol metabolic process [GO:0046339]; fatty acid metabolic process [GO:0006631]; glandular epithelial cell maturation [GO:0002071]; lactation [GO:0007595]; lipid biosynthetic process [GO:0008610]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine biosynthetic process [GO:0006656]; regulation of multicellular organism growth [GO:0040014]; triglyceride biosynthetic process [GO:0019432]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420]; acyl-CoA metabolic process [GO:0006637]; CDP-diacylglycerol biosynthetic process [GO:0016024]; diacylglycerol metabolic process [GO:0046339]; fatty acid metabolic process [GO:0006631]; glandular epithelial cell maturation [GO:0002071]; lactation [GO:0007595]; lipid biosynthetic process [GO:0008610]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine biosynthetic process [GO:0006656]; regulation of multicellular organism growth [GO:0040014]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18238778}; Multi-pass membrane protein {ECO:0000255}.
Q86UL8	reviewed	MAGI2_HUMAN	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Atrophin-1-interacting protein A) (Membrane-associated guanylate kinase inverted 2) (MAGI-2)	MAGI2 ACVRINP1 AIP1 KIAA0705	Homo sapiens (Human)	1455	FUNCTION: Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins (By similarity). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth (By similarity). May play a role in regulating activin-mediated signaling in neuronal cells (By similarity). Enhances the ability of PTEN to suppress AKT1 activation (PubMed:10760291). Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis (By similarity). {ECO:0000250|UniProtKB:O88382, ECO:0000250|UniProtKB:Q9WVQ1, ECO:0000269|PubMed:10760291}.		cellular response to nerve growth factor stimulus [GO:1990090]; clathrin-dependent endocytosis [GO:0072583]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; planar cell polarity pathway involved in axis elongation [GO:0003402]; podocyte development [GO:0072015]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of receptor internalization [GO:0002092]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]	bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; late endosome [GO:0005770]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; slit diaphragm [GO:0036057]; synapse [GO:0045202]	beta-1 adrenergic receptor binding [GO:0031697]; phosphatase binding [GO:0019902]; signaling receptor complex adaptor activity [GO:0030159]; SMAD binding [GO:0046332]; type II activin receptor binding [GO:0070699]	bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; late endosome [GO:0005770]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; slit diaphragm [GO:0036057]; synapse [GO:0045202]; beta-1 adrenergic receptor binding [GO:0031697]; phosphatase binding [GO:0019902]; signaling receptor complex adaptor activity [GO:0030159]; SMAD binding [GO:0046332]; type II activin receptor binding [GO:0070699]; cellular response to nerve growth factor stimulus [GO:1990090]; clathrin-dependent endocytosis [GO:0072583]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; planar cell polarity pathway involved in axis elongation [GO:0003402]; podocyte development [GO:0072015]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of receptor internalization [GO:0002092]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Late endosome {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9WVQ1}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9WVQ1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9WVQ1}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9WVQ1}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9WVQ1}. Note=Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). {ECO:0000250}.
Q86UN2	reviewed	R4RL1_HUMAN	Reticulon-4 receptor-like 1 (Nogo receptor-like 2) (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3)	RTN4RL1 NGRH2 NGRL2	Homo sapiens (Human)	441	FUNCTION: Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). {ECO:0000250|UniProtKB:Q8K0S5, ECO:0000269|PubMed:22325200}.		axon regeneration [GO:0031103]; corpus callosum development [GO:0022038]; negative regulation of axon regeneration [GO:0048681]; negative regulation of neuron projection development [GO:0010977]	cell projection [GO:0042995]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	chondroitin sulfate binding [GO:0035374]; heparin binding [GO:0008201]; signaling receptor activity [GO:0038023]	cell projection [GO:0042995]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; chondroitin sulfate binding [GO:0035374]; heparin binding [GO:0008201]; signaling receptor activity [GO:0038023]; axon regeneration [GO:0031103]; corpus callosum development [GO:0022038]; negative regulation of axon regeneration [GO:0048681]; negative regulation of neuron projection development [GO:0010977]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12694398}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12694398}. Membrane raft {ECO:0000269|PubMed:12694398}. Perikaryon {ECO:0000250|UniProtKB:Q80WD0}. Cell projection {ECO:0000250|UniProtKB:Q80WD0}. Note=Localized to the surface of neurons, including axons. {ECO:0000250|UniProtKB:Q80WD0}.
Q86UN3	reviewed	R4RL2_HUMAN	Reticulon-4 receptor-like 2 (Nogo receptor-like 3) (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2)	RTN4RL2 NGRH1 NGRL3	Homo sapiens (Human)	420	FUNCTION: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). {ECO:0000250|UniProtKB:Q7M6Z0, ECO:0000250|UniProtKB:Q80WD1, ECO:0000269|PubMed:22325200}.		axon regeneration [GO:0031103]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of neuron projection development [GO:0010977]	axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	signaling receptor activity [GO:0038023]	axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; signaling receptor activity [GO:0038023]; axon regeneration [GO:0031103]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of neuron projection development [GO:0010977]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:12839991}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12694398}. Membrane raft {ECO:0000269|PubMed:12694398}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7M6Z0}. Perikaryon {ECO:0000250|UniProtKB:Q80WD1}. Cell projection, axon {ECO:0000250|UniProtKB:Q80WD1}. Note=Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses. {ECO:0000250|UniProtKB:Q7M6Z0}.
Q86UN6	reviewed	AKA28_HUMAN	A-kinase anchor protein 14 (AKAP-14) (A-kinase anchor protein 28 kDa) (AKAP 28) (Protein kinase A-anchoring protein 14) (PRKA14)	AKAP14 AKAP28	Homo sapiens (Human)	197	FUNCTION: Binds to type II regulatory subunits of protein kinase A and anchors/targets them.			axoneme [GO:0005930]; cAMP-dependent protein kinase complex [GO:0005952]	protein kinase A regulatory subunit binding [GO:0034237]	axoneme [GO:0005930]; cAMP-dependent protein kinase complex [GO:0005952]; protein kinase A regulatory subunit binding [GO:0034237]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q86UP0	reviewed	CAD24_HUMAN	Cadherin-24	CDH24 CDH11L UNQ2834/PRO34009	Homo sapiens (Human)	819	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion. {ECO:0000269|PubMed:12734196}.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]	alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; delta-catenin binding [GO:0070097]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; delta-catenin binding [GO:0070097]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q86UP2	reviewed	KTN1_HUMAN	Kinectin (CG-1 antigen) (Kinesin receptor)	KTN1 CG1 KIAA0004	Homo sapiens (Human)	1357	FUNCTION: Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.		microtubule-based movement [GO:0007018]; protein transport [GO:0015031]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; kinesin binding [GO:0019894]; RNA binding [GO:0003723]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; kinesin binding [GO:0019894]; RNA binding [GO:0003723]; microtubule-based movement [GO:0007018]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Vesicle membrane protein anchored to the endoplasmic reticulum.
Q86UP3	reviewed	ZFHX4_HUMAN	Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4)	ZFHX4	Homo sapiens (Human)	3567	FUNCTION: May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86UP6	reviewed	CUZD1_HUMAN	CUB and zona pellucida-like domain-containing protein 1 (CUB and ZP domain-containing protein 1) (Transmembrane protein UO-44)	CUZD1 UNQ224/PRO257	Homo sapiens (Human)	607	FUNCTION: Localized to zymogen granules, where it functions in trypsinogen activation (By similarity). May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (PubMed:15184879). {ECO:0000250|UniProtKB:P70412, ECO:0000269|PubMed:15184879}.		cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; trypsinogen activation [GO:0032023]	cell surface [GO:0009986]; extracellular space [GO:0005615]; membrane [GO:0016020]; zymogen granule membrane [GO:0042589]		cell surface [GO:0009986]; extracellular space [GO:0005615]; membrane [GO:0016020]; zymogen granule membrane [GO:0042589]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; trypsinogen activation [GO:0032023]	SUBCELLULAR LOCATION: Zymogen granule membrane {ECO:0000250|UniProtKB:P70412}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P70412}.
Q86UQ0	reviewed	ZN589_HUMAN	Zinc finger protein 589 (Stem cell zinc finger protein 1)	ZNF589 SZF1	Homo sapiens (Human)	364	FUNCTION: May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor. {ECO:0000269|PubMed:10029171, ECO:0000269|PubMed:12097288}.	MISCELLANEOUS: [Isoform 2]: Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious. Isoform produced through aberrant splice sites. {ECO:0000305}.	negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23665872}.
Q86UQ4	reviewed	ABCAD_HUMAN	ATP-binding cassette sub-family A member 13 (EC 7.6.2.-)	ABCA13	Homo sapiens (Human)	5058	FUNCTION: May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons. {ECO:0000269|PubMed:33478937}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	ceramide transport [GO:0035627]; lipid transport [GO:0006869]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of synaptic vesicle endocytosis [GO:1900244]	azurophil granule membrane [GO:0035577]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]	azurophil granule membrane [GO:0035577]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; ceramide transport [GO:0035627]; lipid transport [GO:0006869]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of synaptic vesicle endocytosis [GO:1900244]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:33478937}; Multi-pass membrane protein {ECO:0000305}.
Q86UQ8	reviewed	NFE4_HUMAN	Transcription factor NF-E4	NFE4	Homo sapiens (Human)	179	FUNCTION: Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter. {ECO:0000269|PubMed:11003662, ECO:0000269|PubMed:15084587, ECO:0000269|PubMed:16263792}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA-binding transcription factor binding [GO:0140297]; protein homodimerization activity [GO:0042803]; transcription coregulator activity [GO:0003712]	nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA-binding transcription factor binding [GO:0140297]; protein homodimerization activity [GO:0042803]; transcription coregulator activity [GO:0003712]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86UR1	reviewed	NOXA1_HUMAN	NADPH oxidase activator 1 (NOX activator 1) (Antigen NY-CO-31) (NCF2-like protein) (P67phox-like factor) (p51-nox)	NOXA1 P51NOX	Homo sapiens (Human)	476	FUNCTION: Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:12716910, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:14978110, ECO:0000269|PubMed:15181005, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:17602954, ECO:0000269|PubMed:19755710}.	MISCELLANEOUS: [Isoform 2]: Mostly inactive for NOX1 activation. Does not interact with NOXO1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Inactive for NOX1 activation. {ECO:0000305}.	regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of respiratory burst [GO:0060263]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	cytosol [GO:0005829]; NADPH oxidase complex [GO:0043020]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]; superoxide-generating NADPH oxidase activator activity [GO:0016176]	cytosol [GO:0005829]; NADPH oxidase complex [GO:0043020]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of respiratory burst [GO:0060263]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
Q86UR5	reviewed	RIMS1_HUMAN	Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2)	RIMS1 KIAA0340 RAB3IP2 RIM1 Nbla00761	Homo sapiens (Human)	1692	FUNCTION: Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}.	MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.	acrosomal vesicle exocytosis [GO:0060478]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of synaptic transmission [GO:0050806]; protein-containing complex assembly [GO:0065003]; regulated exocytosis [GO:0045055]; regulation of membrane potential [GO:0042391]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to stimulus [GO:0050896]; secretion [GO:0046903]; synaptic vesicle exocytosis [GO:0016079]; visual perception [GO:0007601]	cell projection [GO:0042995]; cytoskeleton of presynaptic active zone [GO:0048788]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]	GTPase regulator activity [GO:0030695]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]	cell projection [GO:0042995]; cytoskeleton of presynaptic active zone [GO:0048788]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; GTPase regulator activity [GO:0030695]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]; acrosomal vesicle exocytosis [GO:0060478]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of synaptic transmission [GO:0050806]; protein-containing complex assembly [GO:0065003]; regulated exocytosis [GO:0045055]; regulation of membrane potential [GO:0042391]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to stimulus [GO:0050896]; secretion [GO:0046903]; synaptic vesicle exocytosis [GO:0016079]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q86US8	reviewed	EST1A_HUMAN	Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a)	SMG6 C17orf31 EST1A KIAA0732	Homo sapiens (Human)	1419	FUNCTION: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}.		mRNA export from nucleus [GO:0006406]; negative regulation of telomere capping [GO:1904354]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]; regulation of telomerase activity [GO:0051972]; regulation of telomere maintenance [GO:0032204]; regulation of telomere maintenance via telomerase [GO:0032210]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]	DNA polymerase binding [GO:0070182]; metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]; DNA polymerase binding [GO:0070182]; metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162]; mRNA export from nucleus [GO:0006406]; negative regulation of telomere capping [GO:1904354]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]; regulation of telomerase activity [GO:0051972]; regulation of telomere maintenance [GO:0032204]; regulation of telomere maintenance via telomerase [GO:0032210]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12676087}. Chromosome, telomere {ECO:0000305|PubMed:12699629}. Cytoplasm, cytosol {ECO:0000269|PubMed:12676087}. Note=Particularly enriched in the nucleolus. {ECO:0000269|PubMed:12676087}.
Q86UT5	reviewed	NHRF4_HUMAN	Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4) (Intestinal and kidney-enriched PDZ protein) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (Na/Pi cotransporter C-terminal-associated protein 2) (NaPi-Cap2) (PDZ domain-containing protein 2) (PDZ domain-containing protein 3) (Sodium-hydrogen exchanger regulatory factor 4)	NHERF4 IKEPP PDZD3 PDZK2 DLNB27	Homo sapiens (Human)	571	FUNCTION: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}.		monoatomic ion transport [GO:0006811]; negative regulation of cGMP-mediated signaling [GO:0010754]; protein localization to plasma membrane [GO:0072659]; receptor guanylyl cyclase signaling pathway [GO:0007168]; response to toxic substance [GO:0009636]; water transport [GO:0006833]	apical junction complex [GO:0043296]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	guanylate cyclase inhibitor activity [GO:0030251]; ion channel inhibitor activity [GO:0008200]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; ubiquitin-specific protease binding [GO:1990381]	apical junction complex [GO:0043296]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; guanylate cyclase inhibitor activity [GO:0030251]; ion channel inhibitor activity [GO:0008200]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; ubiquitin-specific protease binding [GO:1990381]; monoatomic ion transport [GO:0006811]; negative regulation of cGMP-mediated signaling [GO:0010754]; protein localization to plasma membrane [GO:0072659]; receptor guanylyl cyclase signaling pathway [GO:0007168]; response to toxic substance [GO:0009636]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451, ECO:0000269|PubMed:22627094}; Peripheral membrane protein {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}. Cytoplasm {ECO:0000269|PubMed:19088451}. Note=Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451). {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}.
Q86UT6	reviewed	NLRX1_HUMAN	NLR family member X1 (Caterpiller protein 11.3) (CLR11.3) (Nucleotide-binding oligomerization domain protein 5) (Nucleotide-binding oligomerization domain protein 9)	NLRX1 NOD5 NOD9	Homo sapiens (Human)	975	FUNCTION: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity). {ECO:0000250|UniProtKB:Q3TL44, ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:27393910}.		innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of RIG-I signaling pathway [GO:0039536]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of RIG-I signaling pathway [GO:0039536]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313, ECO:0000269|PubMed:27393910}.
Q86UT8	reviewed	CATAC_HUMAN	Centrosomal AT-AC splicing factor (Coiled-coil domain-containing protein 84)	CENATAC CCDC84 DLNB14	Homo sapiens (Human)	332	FUNCTION: Component of the minor spliceosome that promotes splicing of a specific, rare minor intron subtype (PubMed:34009673). Negative regulator of centrosome duplication (PubMed:31722219). Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 (PubMed:31722219). {ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34009673}.		chromosome separation [GO:0051304]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of centrosome duplication [GO:0010826]; regulation of protein catabolic process [GO:0042176]	centrosome [GO:0005813]; cytoplasm [GO:0005737]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; chromosome separation [GO:0051304]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of centrosome duplication [GO:0010826]; regulation of protein catabolic process [GO:0042176]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:31722219}. Note=Localizes to the proximal end of the mother centriole. During the cell cycle, from G1 to metaphase, gradually accumulates on the centrosome and then decreased significantly upon entry into anaphase. {ECO:0000269|PubMed:31722219}.
Q86UU0	reviewed	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2)	BCL9L DLNB11	Homo sapiens (Human)	1499	FUNCTION: Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.		canonical Wnt signaling pathway [GO:0060070]; myoblast differentiation [GO:0045445]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell morphogenesis [GO:0022604]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell population maintenance [GO:0035019]; transcription by RNA polymerase II [GO:0006366]	beta-catenin-TCF complex [GO:1990907]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713]	beta-catenin-TCF complex [GO:1990907]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713]; canonical Wnt signaling pathway [GO:0060070]; myoblast differentiation [GO:0045445]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell morphogenesis [GO:0022604]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell population maintenance [GO:0035019]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17129358, ECO:0000269|PubMed:17309600}.
Q86UU1	reviewed	PHLB1_HUMAN	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha)	PHLDB1 KIAA0638 LL5A DLNB07	Homo sapiens (Human)	1377		MISCELLANEOUS: [Isoform 1]: Minor.; MISCELLANEOUS: [Isoform 2]: Major. {ECO:0000305}.	positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]	basal cortex [GO:0045180]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]		basal cortex [GO:0045180]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]	
Q86UU5	reviewed	GGN_HUMAN	Gametogenetin	GGN	Homo sapiens (Human)	652	FUNCTION: May be involved in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; double-strand break repair [GO:0006302]; gamete generation [GO:0007276]; spermatogenesis [GO:0007283]		ubiquitin protein ligase binding [GO:0031625]	ubiquitin protein ligase binding [GO:0031625]; cell differentiation [GO:0030154]; double-strand break repair [GO:0006302]; gamete generation [GO:0007276]; spermatogenesis [GO:0007283]	
Q86UU9	reviewed	TKN4_HUMAN	Tachykinin-4 (Preprotachykinin-C) (PPT-C) [Cleaved into: Endokinin-A (EKA); Endokinin-A/B (EKA/B); Endokinin-C (EKC)]	TAC4	Homo sapiens (Human)	113	FUNCTION: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. {ECO:0000269|PubMed:12716968, ECO:0000269|PubMed:17101218, ECO:0000269|PubMed:17437961, ECO:0000269|PubMed:17655832}.		detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; inflammatory response [GO:0006954]; negative regulation of sensory perception of pain [GO:1904057]; negative regulation of systemic arterial blood pressure [GO:0003085]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of flagellated sperm motility [GO:1902093]; regulation of blood pressure [GO:0008217]; regulation of sensory perception of pain [GO:0051930]; tachykinin receptor signaling pathway [GO:0007217]	extracellular space [GO:0005615]	receptor ligand activity [GO:0048018]; substance K receptor binding [GO:0031837]; substance P receptor binding [GO:0031835]	extracellular space [GO:0005615]; receptor ligand activity [GO:0048018]; substance K receptor binding [GO:0031837]; substance P receptor binding [GO:0031835]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; inflammatory response [GO:0006954]; negative regulation of sensory perception of pain [GO:1904057]; negative regulation of systemic arterial blood pressure [GO:0003085]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of flagellated sperm motility [GO:1902093]; regulation of blood pressure [GO:0008217]; regulation of sensory perception of pain [GO:0051930]; tachykinin receptor signaling pathway [GO:0007217]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86UV5	reviewed	UBP48_HUMAN	Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48)	USP48 USP31	Homo sapiens (Human)	1035	FUNCTION: Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (PubMed:16214042, PubMed:34059922). May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. {ECO:0000269|PubMed:16214042, ECO:0000269|PubMed:34059922}.		proteolysis [GO:0006508]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16214042}. Nucleus {ECO:0000269|PubMed:16214042}.
Q86UV6	reviewed	TRI74_HUMAN	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C)	TRIM74 TRIM50C	Homo sapiens (Human)	250			protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]	
Q86UW1	reviewed	OSTA_HUMAN	Organic solute transporter subunit alpha (OST-alpha) (Solute carrier family 51 subunit alpha)	SLC51A OSTA	Homo sapiens (Human)	340	FUNCTION: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684). Efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed:16317684). Able to transport eicosanoids such as prostaglandin E2 (By similarity). {ECO:0000250|UniProtKB:Q8R000, ECO:0000250|UniProtKB:Q90YM5, ECO:0000269|PubMed:16317684}.		bile acid and bile salt transport [GO:0015721]; bile acid secretion [GO:0032782]	basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	bile acid transmembrane transporter activity [GO:0015125]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; bile acid transmembrane transporter activity [GO:0015125]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; bile acid and bile salt transport [GO:0015721]; bile acid secretion [GO:0032782]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16317684}; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes. {ECO:0000250}.
Q86UW2	reviewed	OSTB_HUMAN	Organic solute transporter subunit beta (OST-beta) (Solute carrier family 51 subunit beta)	SLC51B OSTB	Homo sapiens (Human)	128	FUNCTION: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684). Modulates SLC51A glycosylation, membrane trafficking and stability activities (PubMed:16317684). The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed:16317684). Able to transport eicosanoids such as prostaglandin E2 (By similarity). {ECO:0000250|UniProtKB:Q8R000, ECO:0000250|UniProtKB:Q90YM5, ECO:0000269|PubMed:16317684}.		bile acid and bile salt transport [GO:0015721]; bile acid secretion [GO:0032782]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein glycosylation [GO:0060050]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of protein stability [GO:0031647]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	bile acid transmembrane transporter activity [GO:0015125]; protein heterodimerization activity [GO:0046982]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; bile acid transmembrane transporter activity [GO:0015125]; protein heterodimerization activity [GO:0046982]; bile acid and bile salt transport [GO:0015721]; bile acid secretion [GO:0032782]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein glycosylation [GO:0060050]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}; Single-pass membrane protein {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.
Q86UW6	reviewed	N4BP2_HUMAN	NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein)	N4BP2 B3BP KIAA1413	Homo sapiens (Human)	1770	FUNCTION: Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269|PubMed:12730195}.			cytosol [GO:0005829]	ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; DNA endonuclease activity [GO:0004520]; endonuclease activity [GO:0004519]; ubiquitin binding [GO:0043130]	cytosol [GO:0005829]; ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; DNA endonuclease activity [GO:0004520]; endonuclease activity [GO:0004519]; ubiquitin binding [GO:0043130]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q86UW7	reviewed	CAPS2_HUMAN	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2)	CADPS2 CAPS2 KIAA1591	Homo sapiens (Human)	1296	FUNCTION: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). {ECO:0000250}.		dense core granule exocytosis [GO:1990504]; exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079]	cytoplasmic vesicle membrane [GO:0030659]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; presynapse [GO:0098793]	lipid binding [GO:0008289]; metal ion binding [GO:0046872]	cytoplasmic vesicle membrane [GO:0030659]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; presynapse [GO:0098793]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; dense core granule exocytosis [GO:1990504]; exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.
Q86UW9	reviewed	DTX2_HUMAN	Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2)	DTX2 KIAA1528 RNF58	Homo sapiens (Human)	622	FUNCTION: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.		Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11564735}. Nucleus {ECO:0000269|PubMed:11564735}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000269|PubMed:11564735}.
Q86UX2	reviewed	ITIH5_HUMAN	Inter-alpha-trypsin inhibitor heavy chain H5 (ITI heavy chain H5) (ITI-HC5) (Inter-alpha-inhibitor heavy chain 5)	ITIH5 KIAA1953 PP14776 UNQ311/PRO354	Homo sapiens (Human)	942	FUNCTION: May act as a tumor suppressor.		hyaluronan metabolic process [GO:0030212]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]; hyaluronan metabolic process [GO:0030212]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q86UX6	reviewed	ST32C_HUMAN	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (Yet another novel kinase 3)	STK32C YANK3	Homo sapiens (Human)	486			intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]		ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	
Q86UX7	reviewed	URP2_HUMAN	Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2)	FERMT3 KIND3 MIG2B URP2	Homo sapiens (Human)	667	FUNCTION: Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}.		cell-matrix adhesion [GO:0007160]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; platelet aggregation [GO:0070527]; positive regulation of cell migration [GO:0030335]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; substrate adhesion-dependent cell spreading [GO:0034446]	cell projection [GO:0042995]; cell-substrate junction [GO:0030055]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; podosome [GO:0002102]	integrin binding [GO:0005178]; lipid binding [GO:0008289]	cell projection [GO:0042995]; cell-substrate junction [GO:0030055]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; podosome [GO:0002102]; integrin binding [GO:0005178]; lipid binding [GO:0008289]; cell-matrix adhesion [GO:0007160]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; platelet aggregation [GO:0070527]; positive regulation of cell migration [GO:0030335]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Cell projection, podosome {ECO:0000250}. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells. {ECO:0000250}.
Q86UY5	reviewed	FA83A_HUMAN	Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein)	FAM83A TSGP	Homo sapiens (Human)	434	FUNCTION: Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. {ECO:0000269|PubMed:22886303}.		cell population proliferation [GO:0008283]; epidermal growth factor receptor signaling pathway [GO:0007173]	cytoplasm [GO:0005737]	identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein kinase binding [GO:0019901]; cell population proliferation [GO:0008283]; epidermal growth factor receptor signaling pathway [GO:0007173]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:22886303}.
Q86UY6	reviewed	NAA40_HUMAN	N-alpha-acetyltransferase 40 (EC 2.3.1.257) (N-acetyltransferase 11) (N-alpha-acetyltransferase D) (NatD) (hNatD) (Protein acetyltransferase 1)	NAA40 NAT11 PATT1	Homo sapiens (Human)	237	FUNCTION: N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (PubMed:21935442, PubMed:25619998). Acts as a negative regulator of apoptosis (PubMed:26666750). May play a role in hepatic lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q8VE10, ECO:0000269|PubMed:21935442, ECO:0000269|PubMed:25619998, ECO:0000269|PubMed:26666750}.		lipid metabolic process [GO:0006629]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone H2A acetyltransferase activity [GO:0043998]; histone H4 acetyltransferase activity [GO:0010485]; peptide-serine-alpha-N-acetyltransferase activity [GO:1990189]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone H2A acetyltransferase activity [GO:0043998]; histone H4 acetyltransferase activity [GO:0010485]; peptide-serine-alpha-N-acetyltransferase activity [GO:1990189]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25732826}. Nucleus {ECO:0000269|PubMed:25732826}.
Q86UZ6	reviewed	ZBT46_HUMAN	Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340)	ZBTB46 BTBD4 ZNF340	Homo sapiens (Human)	589	FUNCTION: Functions as a transcriptional repressor for PRDM1. {ECO:0000250}.		granulocyte differentiation [GO:0030851]; macrophage differentiation [GO:0030225]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of leukocyte activation [GO:0002695]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of transcription by RNA polymerase II [GO:0000122]; plasmacytoid dendritic cell differentiation [GO:0002273]; positive regulation of dendritic cell differentiation [GO:2001200]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; granulocyte differentiation [GO:0030851]; macrophage differentiation [GO:0030225]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of leukocyte activation [GO:0002695]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of transcription by RNA polymerase II [GO:0000122]; plasmacytoid dendritic cell differentiation [GO:0002273]; positive regulation of dendritic cell differentiation [GO:2001200]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86V15	reviewed	CASZ1_HUMAN	Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693)	CASZ1 CST SRG ZNF693	Homo sapiens (Human)	1759	FUNCTION: Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}.	MISCELLANEOUS: Endothelial cells depleted in CASZ1 by siRNAs display dramatic alterations in adhesion, morphology and sprouting; normal behavior can be rescued by restoration of EGFL7 expression. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization.	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron differentiation [GO:0045664]	chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron differentiation [GO:0045664]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16631614}.
Q86V20	reviewed	SHLD2_HUMAN	Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2)	SHLD2 FAM35A RINN2	Homo sapiens (Human)	835	FUNCTION: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). {ECO:0000269|PubMed:29656893, ECO:0000269|PubMed:29789392}.	MISCELLANEOUS: In BRCA1-deficient cells, function of the shieldin complex is necessary for sensitivity to camptothecin and the PARP inhibitor olaparib. {ECO:0000269|PubMed:29656893, ECO:0000269|PubMed:29789392}.	DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; regulation of double-strand break repair via homologous recombination [GO:0010569]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]		actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; regulation of double-strand break repair via homologous recombination [GO:0010569]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29656893, ECO:0000269|PubMed:29789392}. Chromosome {ECO:0000269|PubMed:29656893, ECO:0000305|PubMed:29789392}. Note=Localizes to nuclear foci in response to DNA damage. {ECO:0000269|PubMed:29656893, ECO:0000269|PubMed:29789392}.
Q86V24	reviewed	PAQR2_HUMAN	Adiponectin receptor protein 2 (Progestin and adipoQ receptor family member 2) (Progestin and adipoQ receptor family member II)	ADIPOR2 PAQR2	Homo sapiens (Human)	386	FUNCTION: Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity). {ECO:0000250|UniProtKB:Q8BQS5, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}.		adiponectin-activated signaling pathway [GO:0033211]; fatty acid oxidation [GO:0019395]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of cold-induced thermogenesis [GO:0120162]; vascular wound healing [GO:0061042]	plasma membrane [GO:0005886]	adipokinetic hormone receptor activity [GO:0097003]; adiponectin binding [GO:0055100]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; adipokinetic hormone receptor activity [GO:0097003]; adiponectin binding [GO:0055100]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; signaling receptor activity [GO:0038023]; adiponectin-activated signaling pathway [GO:0033211]; fatty acid oxidation [GO:0019395]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of cold-induced thermogenesis [GO:0120162]; vascular wound healing [GO:0061042]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}; Multi-pass membrane protein {ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}. Note=Localized to the cell membrane and intracellular organelles. {ECO:0000269|PubMed:12802337}.
Q86V25	reviewed	VASH2_HUMAN	Tubulinyl-Tyr carboxypeptidase 2 (EC 3.4.17.17) (Vasohibin-2) (Vasohibin-like protein)	VASH2 VASHL	Homo sapiens (Human)	355	FUNCTION: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911). {ECO:0000269|PubMed:19204325, ECO:0000269|PubMed:29146869, ECO:0000269|PubMed:31235911}.		axon development [GO:0061564]; cell-cell fusion [GO:0140253]; labyrinthine layer blood vessel development [GO:0060716]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; proteolysis [GO:0006508]; regulation of angiogenesis [GO:0045765]; syncytium formation by plasma membrane fusion [GO:0000768]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]	actin binding [GO:0003779]; metallocarboxypeptidase activity [GO:0004181]; microtubule binding [GO:0008017]; tubulin-tyrosine carboxypeptidase [GO:0106423]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; actin binding [GO:0003779]; metallocarboxypeptidase activity [GO:0004181]; microtubule binding [GO:0008017]; tubulin-tyrosine carboxypeptidase [GO:0106423]; axon development [GO:0061564]; cell-cell fusion [GO:0140253]; labyrinthine layer blood vessel development [GO:0060716]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; proteolysis [GO:0006508]; regulation of angiogenesis [GO:0045765]; syncytium formation by plasma membrane fusion [GO:0000768]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19204325}. Secreted {ECO:0000269|PubMed:20736312}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:31235911}. Note=Mainly localizes in the cytoplasm (PubMed:19204325). Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:20736312). Associates with microtubules (PubMed:31235911). {ECO:0000269|PubMed:19204325, ECO:0000269|PubMed:20736312, ECO:0000269|PubMed:31235911}.
Q86V40	reviewed	TIKI1_HUMAN	Metalloprotease TIKI1 (EC 3.4.-.-) (TRAB domain-containing protein 2A)	TRABD2A C2orf89 TIKI1	Homo sapiens (Human)	505	FUNCTION: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. {ECO:0000269|PubMed:22726442}.	MISCELLANEOUS: Was named TIKI in reference to large-headed humanoid in Polynesian mythology. {ECO:0000305|PubMed:22726442}.	head development [GO:0060322]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein oxidation [GO:1904808]; positive regulation of protein-containing complex assembly [GO:0031334]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055]	membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]	endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; Wnt-protein binding [GO:0017147]	membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; Wnt-protein binding [GO:0017147]; head development [GO:0060322]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein oxidation [GO:1904808]; positive regulation of protein-containing complex assembly [GO:0031334]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22726442}; Single-pass type I membrane protein {ECO:0000269|PubMed:22726442}.
Q86V42	reviewed	F124A_HUMAN	Protein FAM124A	FAM124A	Homo sapiens (Human)	546							
Q86V48	reviewed	LUZP1_HUMAN	Leucine zipper protein 1	LUZP1	Homo sapiens (Human)	1076			artery development [GO:0060840]; neural fold bending [GO:0021503]; ventricular septum development [GO:0003281]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; artery development [GO:0060840]; neural fold bending [GO:0021503]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26638075}. Nucleus {ECO:0000250|UniProtKB:Q9ESV1}. Note=Also detected in soma and dendrites of neurons. {ECO:0000250|UniProtKB:Q9ESV1}.
Q86V81	reviewed	THOC4_HUMAN	THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF)	ALYREF ALY BEF THOC4	Homo sapiens (Human)	257	FUNCTION: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway) (PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:11707413, PubMed:11675789, PubMed:11979277, PubMed:18364396, PubMed:22144908, PubMed:22893130, PubMed:23222130, PubMed:25662211). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm (PubMed:15833825, PubMed:15998806, PubMed:17190602). TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1 (PubMed:15833825, PubMed:15998806, PubMed:17190602). The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA (PubMed:18974867). Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC) (PubMed:15998806, PubMed:17984224). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim (PubMed:19165146). Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability (PubMed:12438613, PubMed:17984224). Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling (PubMed:28418038). {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:11707413, ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:12438613, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:25662211, ECO:0000269|PubMed:28418038}.; FUNCTION: Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. {ECO:0000269|PubMed:10488337}.	MISCELLANEOUS: Antibodies against ALYREF/THOC4 are found in sera of patients with systemic lupus erythematosus (SLE).	mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; regulation of DNA recombination [GO:0000018]; replication fork processing [GO:0031297]; RNA export from nucleus [GO:0006405]; viral mRNA export from host cell nucleus [GO:0046784]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex [GO:0000346]	C5-methylcytidine-containing RNA binding [GO:0062153]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex [GO:0000346]; C5-methylcytidine-containing RNA binding [GO:0062153]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; regulation of DNA recombination [GO:0000018]; replication fork processing [GO:0031297]; RNA export from nucleus [GO:0006405]; viral mRNA export from host cell nucleus [GO:0046784]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10488337, ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332, ECO:0000269|PubMed:28418038, ECO:0000305|PubMed:18974867}. Nucleus speckle {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332}. Cytoplasm {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:28418038}. Note=Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and DDX39B in the nucleus and nuclear speckles. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:19324961). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332). {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332}.
Q86V86	reviewed	PIM3_HUMAN	Serine/threonine-protein kinase pim-3 (EC 2.7.11.1)	PIM3	Homo sapiens (Human)	326	FUNCTION: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021, ECO:0000269|PubMed:17876606, ECO:0000269|PubMed:18593906}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]; negative regulation of apoptotic process [GO:0043066]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle [GO:0007346]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; negative regulation of apoptotic process [GO:0043066]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17876606}.
Q86V97	reviewed	KBTB6_HUMAN	Kelch repeat and BTB domain-containing protein 6	KBTBD6	Homo sapiens (Human)	674	FUNCTION: As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205). {ECO:0000269|PubMed:25684205}.		negative regulation of signal transduction [GO:0009968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of Rac protein signal transduction [GO:0035020]; response to unfolded protein [GO:0006986]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]		Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; negative regulation of signal transduction [GO:0009968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of Rac protein signal transduction [GO:0035020]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25684205}. Nucleus {ECO:0000269|PubMed:25684205}.
Q86VB7	reviewed	C163A_HUMAN	Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)]	CD163 M130	Homo sapiens (Human)	1156	FUNCTION: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.; FUNCTION: After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.	MISCELLANEOUS: Intravenous lipopolysaccharide (LPS) produces a rapid rise of sCD163 in plasma of patient as it induces metalloproteinase-mediated shedding from monocytes surface. Long-term LPS infusion finally increases expression of the membrane-bound form on circulating monocytes.; MISCELLANEOUS: The soluble form (sCD163) in plasma is a novel parameter in diseases affecting macrophage function and monocyte/macrophage load in the body. The concentration of sCD163 is probably reflecting the number of macrophages of the 'alternative macrophage activation' phenotype with a high CD163 expression playing a major role in dampening the inflammatory response and scavenging components of damaged cells. This has initiated a number of clinical studies for evaluation of sCD163 as a disease marker in inflammatory conditions e.g. infection, autoimmune disease, transplantation, atherosclerosis and cancer.	acute-phase response [GO:0006953]	cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	scaffold protein binding [GO:0097110]; scavenger receptor activity [GO:0005044]	cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; scaffold protein binding [GO:0097110]; scavenger receptor activity [GO:0005044]; acute-phase response [GO:0006953]	SUBCELLULAR LOCATION: [Soluble CD163]: Secreted {ECO:0000269|PubMed:12296867}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10577520, ECO:0000269|PubMed:10648003}; Single-pass type I membrane protein {ECO:0000269|PubMed:10577520, ECO:0000269|PubMed:10648003}. Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.
Q86VD1	reviewed	MORC1_HUMAN	MORC family CW-type zinc finger protein 1 (Cancer/testis antigen 33) (CT33)	MORC1 MORC	Homo sapiens (Human)	984	FUNCTION: Required for spermatogenesis (By similarity). Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity). {ECO:0000250|UniProtKB:Q9WVL5}.		behavioral fear response [GO:0001662]; genomic imprinting [GO:0071514]; negative regulation of DNA-templated transcription initiation [GO:2000143]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposition [GO:0032197]; retrotransposon silencing by heterochromatin formation [GO:0141005]; spermatogenesis [GO:0007283]	male germ cell nucleus [GO:0001673]; nucleus [GO:0005634]	zinc ion binding [GO:0008270]	male germ cell nucleus [GO:0001673]; nucleus [GO:0005634]; zinc ion binding [GO:0008270]; behavioral fear response [GO:0001662]; genomic imprinting [GO:0071514]; negative regulation of DNA-templated transcription initiation [GO:2000143]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposition [GO:0032197]; retrotransposon silencing by heterochromatin formation [GO:0141005]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9WVL5}.
Q86VD7	reviewed	S2542_HUMAN	Mitochondrial coenzyme A transporter SLC25A42 (Solute carrier family 25 member 42)	SLC25A42	Homo sapiens (Human)	318	FUNCTION: Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate. {ECO:0000269|PubMed:19429682}.		ADP transport [GO:0015866]; AMP transport [GO:0080121]; ATP transport [GO:0015867]; coenzyme A transmembrane transport [GO:0035349]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	ADP phosphatase activity [GO:0043262]; ADP transmembrane transporter activity [GO:0015217]; AMP transmembrane transporter activity [GO:0080122]; ATP transmembrane transporter activity [GO:0005347]; coenzyme A transmembrane transporter activity [GO:0015228]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ADP phosphatase activity [GO:0043262]; ADP transmembrane transporter activity [GO:0015217]; AMP transmembrane transporter activity [GO:0080122]; ATP transmembrane transporter activity [GO:0005347]; coenzyme A transmembrane transporter activity [GO:0015228]; ADP transport [GO:0015866]; AMP transport [GO:0080121]; ATP transport [GO:0015867]; coenzyme A transmembrane transport [GO:0035349]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:19429682}; Multi-pass membrane protein {ECO:0000269|PubMed:19429682}.
Q86VD9	reviewed	PIGZ_HUMAN	GPI mannosyltransferase 4 (EC 2.4.1.-) (GPI mannosyltransferase IV) (GPI-MT-IV) (Phosphatidylinositol-glycan biosynthesis class Z protein) (PIG-Z) (SMP3 homolog) (hSMP3)	PIGZ SMP3	Homo sapiens (Human)	579	FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues. {ECO:0000269|PubMed:15208306}.		GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	alpha-1,2-mannosyltransferase activity [GO:0000026]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; alpha-1,2-mannosyltransferase activity [GO:0000026]; mannosyltransferase activity [GO:0000030]; GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15208306}; Multi-pass membrane protein {ECO:0000269|PubMed:15208306}.
Q86VE0	reviewed	MYPOP_HUMAN	Myb-related transcription factor, partner of profilin (Myb-related protein p42POP) (Partner of profilin)	MYPOP P42POP	Homo sapiens (Human)	399	FUNCTION: Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity). {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q86VE9	reviewed	SERC5_HUMAN	Serine incorporator 5	SERINC5 C5orf12	Homo sapiens (Human)	423	FUNCTION: Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). {ECO:0000250|UniProtKB:Q63175, ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}.		defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; L-serine biosynthetic process [GO:0006564]; myelination [GO:0042552]; phosphatidylserine metabolic process [GO:0006658]; phospholipid biosynthetic process [GO:0008654]; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity [GO:1904219]; positive regulation of serine C-palmitoyltransferase activity [GO:1904222]	centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; myelin sheath [GO:0043209]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	L-serine transmembrane transporter activity [GO:0015194]	centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; myelin sheath [GO:0043209]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; L-serine transmembrane transporter activity [GO:0015194]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; L-serine biosynthetic process [GO:0006564]; myelination [GO:0042552]; phosphatidylserine metabolic process [GO:0006658]; phospholipid biosynthetic process [GO:0008654]; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity [GO:1904219]; positive regulation of serine C-palmitoyltransferase activity [GO:1904222]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:26416734, ECO:0000305|PubMed:26416733}. Note=(Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (PubMed:26416733, PubMed:26416734). Localizes to the cell membrane, where it is efficiently incorporated into budding virions and impairs subsequent virion entry into target cells (PubMed:26416733, PubMed:26416734). {ECO:0000269|PubMed:26416734, ECO:0000305|PubMed:26416733}.
Q86VF2	reviewed	IGFN1_HUMAN	Immunoglobulin-like and fibronectin type III domain-containing protein 1 (EEF1A2-binding protein 1) (KY-interacting protein 1)	IGFN1 EEF1A2BP1 KYIP1	Homo sapiens (Human)	1251				nucleus [GO:0005634]; Z disc [GO:0030018]		nucleus [GO:0005634]; Z disc [GO:0030018]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
Q86VF5	reviewed	MOGT3_HUMAN	2-acylglycerol O-acyltransferase 3 (EC 2.3.1.20) (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 3) (MGAT3) (Diacylglycerol O-acyltransferase candidate 7) (hDC7) (Diacylglycerol acyltransferase 2-like protein 7) (Monoacylglycerol O-acyltransferase 3)	MOGAT3 DC7 DGAT2L7 UNQ9383/PRO34208	Homo sapiens (Human)	341	FUNCTION: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000269|PubMed:12618427, ECO:0000269|PubMed:27184406, ECO:0000269|PubMed:28420705}.		glycerol metabolic process [GO:0006071]; monoacylglycerol biosynthetic process [GO:0006640]; triglyceride biosynthetic process [GO:0019432]	endoplasmic reticulum membrane [GO:0005789]; perinuclear endoplasmic reticulum membrane [GO:1990578]	2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]	endoplasmic reticulum membrane [GO:0005789]; perinuclear endoplasmic reticulum membrane [GO:1990578]; 2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]; glycerol metabolic process [GO:0006071]; monoacylglycerol biosynthetic process [GO:0006640]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27184406}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27184406}.
Q86VF7	reviewed	NRAP_HUMAN	Nebulin-related-anchoring protein (N-RAP)	NRAP	Homo sapiens (Human)	1730	FUNCTION: May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. {ECO:0000250|UniProtKB:Q80XB4}.		cardiac muscle thin filament assembly [GO:0071691]	fascia adherens [GO:0005916]; muscle tendon junction [GO:0005927]; Z disc [GO:0030018]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; vinculin binding [GO:0017166]	fascia adherens [GO:0005916]; muscle tendon junction [GO:0005927]; Z disc [GO:0030018]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; vinculin binding [GO:0017166]; cardiac muscle thin filament assembly [GO:0071691]	SUBCELLULAR LOCATION: Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle. {ECO:0000269|PubMed:12789664}.
Q86VH2	reviewed	KIF27_HUMAN	Kinesin-like protein KIF27	KIF27	Homo sapiens (Human)	1401	FUNCTION: Plays an essential role in motile ciliogenesis. {ECO:0000250}.		cilium assembly [GO:0060271]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; microtubule-based movement [GO:0007018]; ventricular system development [GO:0021591]	cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; kinesin complex [GO:0005871]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; cilium assembly [GO:0060271]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; microtubule-based movement [GO:0007018]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, cilium {ECO:0000250}. Note=Localizes to centrioles and basal bodies. {ECO:0000250}.
Q86VH5	reviewed	LRRT3_HUMAN	Leucine-rich repeat transmembrane neuronal protein 3	LRRTM3 UNQ803/PRO1693	Homo sapiens (Human)	581	FUNCTION: Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system. {ECO:0000250}.		positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q86VI3	reviewed	IQGA3_HUMAN	Ras GTPase-activating-like protein IQGAP3	IQGAP3	Homo sapiens (Human)	1631			cellular response to organic substance [GO:0071310]; ERK1 and ERK2 cascade [GO:0070371]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; mammary gland epithelial cell proliferation [GO:0033598]; mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; Ras protein signal transduction [GO:0007265]; regulation of cell size [GO:0008361]	cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]	actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; myosin VI light chain binding [GO:0070856]; small GTPase binding [GO:0031267]	cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; myosin VI light chain binding [GO:0070856]; small GTPase binding [GO:0031267]; cellular response to organic substance [GO:0071310]; ERK1 and ERK2 cascade [GO:0070371]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; mammary gland epithelial cell proliferation [GO:0033598]; mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; Ras protein signal transduction [GO:0007265]; regulation of cell size [GO:0008361]	
Q86VI4	reviewed	LAP4B_HUMAN	Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta)	LAPTM4B PSEC0001	Homo sapiens (Human)	317	FUNCTION: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656). {ECO:0000269|PubMed:21224396, ECO:0000269|PubMed:25588945, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:26126825, ECO:0000269|PubMed:26280656}.		endosome organization [GO:0007032]; endosome transport via multivesicular body sorting pathway [GO:0032509]; negative regulation of lysosomal protein catabolic process [GO:1905166]; negative regulation of transforming growth factor beta1 production [GO:0032911]; regulation of lysosomal membrane permeability [GO:0097213]; regulation of lysosome organization [GO:1905671]	cell projection [GO:0042995]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; multivesicular body membrane [GO:0032585]; multivesicular body, internal vesicle [GO:0097487]; plasma membrane [GO:0005886]	ceramide binding [GO:0097001]; kinase binding [GO:0019900]; phosphatidylinositol bisphosphate binding [GO:1902936]; ubiquitin protein ligase binding [GO:0031625]	cell projection [GO:0042995]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; multivesicular body membrane [GO:0032585]; multivesicular body, internal vesicle [GO:0097487]; plasma membrane [GO:0005886]; ceramide binding [GO:0097001]; kinase binding [GO:0019900]; phosphatidylinositol bisphosphate binding [GO:1902936]; ubiquitin protein ligase binding [GO:0031625]; endosome organization [GO:0007032]; endosome transport via multivesicular body sorting pathway [GO:0032509]; negative regulation of lysosomal protein catabolic process [GO:1905166]; negative regulation of transforming growth factor beta1 production [GO:0032911]; regulation of lysosomal membrane permeability [GO:0097213]; regulation of lysosome organization [GO:1905671]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:12902989}; Multi-pass membrane protein {ECO:0000269|PubMed:12902989}. Late endosome membrane {ECO:0000269|PubMed:21224396, ECO:0000269|PubMed:22096579, ECO:0000269|PubMed:25588945}. Cell membrane {ECO:0000269|PubMed:22096579}. Cell projection {ECO:0000269|PubMed:22096579}. Lysosome membrane {ECO:0000269|PubMed:21224396, ECO:0000269|PubMed:22096579}. Endosome membrane. Endosome, multivesicular body membrane {ECO:0000269|PubMed:26280656}. Endosome, multivesicular body lumen {ECO:0000269|PubMed:26280656}.
Q86VK4	reviewed	ZN410_HUMAN	Zinc finger protein 410 (Another partner for ARF 1)	ZNF410 APA1	Homo sapiens (Human)	478	FUNCTION: Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416, PubMed:33301730). Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416, PubMed:33301730). May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286). May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215). However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33859416, PubMed:33301730). {ECO:0000269|PubMed:12370286, ECO:0000269|PubMed:30078215, ECO:0000269|PubMed:33301730, ECO:0000269|PubMed:33859416}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	negative regulation of gene expression [GO:0010629]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromosome [GO:0005694]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coregulator activity [GO:0003712]	chromosome [GO:0005694]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coregulator activity [GO:0003712]; negative regulation of gene expression [GO:0010629]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:33301730, ECO:0000305|PubMed:33859416}. Chromosome {ECO:0000269|PubMed:33301730, ECO:0000269|PubMed:33859416}. Note=Directly binds to the sequence motif 5'-CATCCCATAATA-3'. {ECO:0000269|PubMed:33301730, ECO:0000269|PubMed:33859416}.
Q86VL8	reviewed	S47A2_HUMAN	Multidrug and toxin extrusion protein 2 (MATE-2) (hMATE-2) (Kidney-specific H(+)/organic cation antiporter) (Solute carrier family 47 member 2)	SLC47A2 MATE2	Homo sapiens (Human)	602	FUNCTION: Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney. {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:16914559, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:19158817, ECO:0000269|PubMed:21419862}.; FUNCTION: [Isoform 6]: Non-functional protein. {ECO:0000269|PubMed:16807400}.		organic cation transport [GO:0015695]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]	antiporter activity [GO:0015297]; organic cation transmembrane transporter activity [GO:0015101]; polyspecific organic cation:proton antiporter activity [GO:0140968]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; organic cation transmembrane transporter activity [GO:0015101]; polyspecific organic cation:proton antiporter activity [GO:0140968]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]; organic cation transport [GO:0015695]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19158817}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:21419862}; Multi-pass membrane protein {ECO:0000255}. Note=Detected in the renal urinary tubules. {ECO:0000269|PubMed:21419862}.; SUBCELLULAR LOCATION: [Isoform 6]: Apical cell membrane {ECO:0000269|PubMed:16807400}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of the proximal tubules. {ECO:0000269|PubMed:16807400}.
Q86VM9	reviewed	ZCH18_HUMAN	Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1)	ZC3H18 NHN1	Homo sapiens (Human)	953			RNA destabilization [GO:0050779]	nuclear speck [GO:0016607]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]	metal ion binding [GO:0046872]; mRNA cap binding complex binding [GO:0140262]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; metal ion binding [GO:0046872]; mRNA cap binding complex binding [GO:0140262]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; RNA destabilization [GO:0050779]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q86VN1	reviewed	VPS36_HUMAN	Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36)	VPS36 C13orf9 EAP45 CGI-145	Homo sapiens (Human)	386	FUNCTION: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.		macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]	cytosol [GO:0005829]; endosome [GO:0005768]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; nucleus [GO:0005634]	phosphatidylinositol-3-phosphate binding [GO:0032266]; ubiquitin binding [GO:0043130]	cytosol [GO:0005829]; endosome [GO:0005768]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; nucleus [GO:0005634]; phosphatidylinositol-3-phosphate binding [GO:0032266]; ubiquitin binding [GO:0043130]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]	SUBCELLULAR LOCATION: Cytoplasm. Endosome. Late endosome {ECO:0000250|UniProtKB:Q91XD6}. Membrane. Nucleus {ECO:0000305}. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation. {ECO:0000250|UniProtKB:Q91XD6}.
Q86VP1	reviewed	TAXB1_HUMAN	Tax1-binding protein 1 (TRAF6-binding protein)	TAX1BP1 T6BP PRO0105	Homo sapiens (Human)	789	FUNCTION: Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:30459273, PubMed:29940186, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}.		apoptotic process [GO:0006915]; autophagy [GO:0006914]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407]	kinase binding [GO:0019900]; metal ion binding [GO:0046872]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; apoptotic process [GO:0006915]; autophagy [GO:0006914]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30909570}. Mitochondrion {ECO:0000269|PubMed:27736772}. Preautophagosomal structure {ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:26451915}.
Q86VP3	reviewed	PACS2_HUMAN	Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein)	PACS2 KIAA0602 PACS1L	Homo sapiens (Human)	889	FUNCTION: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}.		apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; protein localization to phagophore assembly site [GO:0034497]; protein localization to plasma membrane [GO:0072659]	endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]	transmembrane transporter binding [GO:0044325]	endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; transmembrane transporter binding [GO:0044325]; apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; protein localization to phagophore assembly site [GO:0034497]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:15692567}. Mitochondrion {ECO:0000269|PubMed:15692567}.
Q86VP6	reviewed	CAND1_HUMAN	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)	CAND1 KIAA0829 TIP120 TIP120A	Homo sapiens (Human)	1230	FUNCTION: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}.	MISCELLANEOUS: A model has been proposed to explain the mechanisms of cullin-RING E3 ubiquitin ligase complexes assembly. According to this hypothesis, cullin-RING E3 ubiquitin ligase complexes exist in a 'stable' active state when saturated with substrate, occluding access to deneddylation by the COP9 signalosome (CSN) complex. The neddylation-conjugated cullin-RING E3 ubiquitin ligase complexes mediate ubiquitination of substrates and can recruit downstream factors involved in substrate degradation. Depletion of the substrate promotes the ability of CSN to bind the cullin-RING E3 ubiquitin ligase complex and mediate deneddylation. In this 'intermediate' deneddylated state, the complex can bind CAND1 and enter the 'exchange' state, resulting in high increase in dissociation rate of the substrate-recognition subunit. The resulting CAND1-cullin-RING complex rapidly assembles with another available substrate-recognition subunit to form an unstable ternary intermediate and yield a new cullin-RING E3 ubiquitin ligase complex. Subsequent neddylation of the cullin, which is stabilized by substrate, completes the cycle (PubMed:23453757). {ECO:0000305|PubMed:23453757}.	cell differentiation [GO:0030154]; negative regulation of catalytic activity [GO:0043086]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265]	cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; ubiquitin ligase complex [GO:0000151]	TBP-class protein binding [GO:0017025]	cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; ubiquitin ligase complex [GO:0000151]; TBP-class protein binding [GO:0017025]; cell differentiation [GO:0030154]; negative regulation of catalytic activity [GO:0043086]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21249194}. Nucleus {ECO:0000269|PubMed:21249194}. Note=Predominantly cytoplasmic.
Q86VQ0	reviewed	LCA5_HUMAN	Lebercilin (Leber congenital amaurosis 5 protein)	LCA5 C6orf152	Homo sapiens (Human)	697	FUNCTION: Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. {ECO:0000250|UniProtKB:Q80ST9}.		intraciliary transport [GO:0042073]; photoreceptor cell maintenance [GO:0045494]; protein transport [GO:0015031]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; photoreceptor connecting cilium [GO:0032391]	protein-containing complex binding [GO:0044877]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; photoreceptor connecting cilium [GO:0032391]; protein-containing complex binding [GO:0044877]; intraciliary transport [GO:0042073]; photoreceptor cell maintenance [GO:0045494]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17546029}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:17546029}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17546029}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17546029}. Cell projection, cilium {ECO:0000269|PubMed:21606596}. Note=In non- ciliated cells, localizes to the centrosome and its associated microtubule array (PubMed:17546029). Colocalizes with IFT complex A and B proteins in the connecting cilium in primary cilia of hTERT-RPE1 cells (PubMed:21606596). {ECO:0000269|PubMed:17546029, ECO:0000269|PubMed:21606596}.
Q86VQ3	reviewed	TXND2_HUMAN	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1)	TXNDC2 SPTRX SPTRX1	Homo sapiens (Human)	553	FUNCTION: Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.		cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]	thioredoxin-disulfide reductase (NADP) activity [GO:0004791]	cytoplasm [GO:0005737]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]; cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11399755}. Note=In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.
Q86VQ6	reviewed	TRXR3_HUMAN	Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase TR2)	TXNRD3 TGR TRXR3	Homo sapiens (Human)	643	FUNCTION: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). {ECO:0000250|UniProtKB:Q99MD6}.	MISCELLANEOUS: The thioredoxin reductase active site is a redox-active disulfide bond. The selenocysteine residue is also essential for catalytic activity (By similarity). {ECO:0000250|UniProtKB:Q16881}.	cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	flavin adenine dinucleotide binding [GO:0050660]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; flavin adenine dinucleotide binding [GO:0050660]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]; cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99MD6}. Nucleus {ECO:0000250|UniProtKB:Q99MD6}. Microsome {ECO:0000250|UniProtKB:Q99MD6}. Endoplasmic reticulum {ECO:0000250}. Note=Detected in cytoplasm and nucleus in late spermatids. {ECO:0000250|UniProtKB:Q99MD6}.
Q86VR2	reviewed	RETR3_HUMAN	Reticulophagy regulator 3	RETREG3 FAM134C	Homo sapiens (Human)	466	FUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}.		collagen catabolic process [GO:0030574]; endoplasmic reticulum tubular network organization [GO:0071786]; positive regulation of neuron projection development [GO:0010976]; reticulophagy [GO:0061709]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; protein-containing complex [GO:0032991]	endoplasmic reticulum-autophagosome adaptor activity [GO:0140506]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; protein-containing complex [GO:0032991]; endoplasmic reticulum-autophagosome adaptor activity [GO:0140506]; collagen catabolic process [GO:0030574]; endoplasmic reticulum tubular network organization [GO:0071786]; positive regulation of neuron projection development [GO:0010976]; reticulophagy [GO:0061709]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes preferentially to endoplasmic reticulum tubules and sheet edges. {ECO:0000269|PubMed:33826365}.
Q86VS8	reviewed	HOOK3_HUMAN	Protein Hook homolog 3 (h-hook3) (hHK3)	HOOK3	Homo sapiens (Human)	718	FUNCTION: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33734450}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}.		cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; Golgi localization [GO:0051645]; interkinetic nuclear migration [GO:0022027]; lysosome organization [GO:0007040]; microtubule anchoring at centrosome [GO:0034454]; negative regulation of neurogenesis [GO:0050768]; neuronal stem cell population maintenance [GO:0097150]; protein localization to centrosome [GO:0071539]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FHF complex [GO:0070695]; microtubule [GO:0005874]; pericentriolar material [GO:0000242]	dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; dynein light chain binding [GO:0045503]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FHF complex [GO:0070695]; microtubule [GO:0005874]; pericentriolar material [GO:0000242]; dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; dynein light chain binding [GO:0045503]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; Golgi localization [GO:0051645]; interkinetic nuclear migration [GO:0022027]; lysosome organization [GO:0007040]; microtubule anchoring at centrosome [GO:0034454]; negative regulation of neurogenesis [GO:0050768]; neuronal stem cell population maintenance [GO:0097150]; protein localization to centrosome [GO:0071539]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11238449}. Golgi apparatus {ECO:0000269|PubMed:11238449}. Note=Enriched at the cis-face of the Golgi complex. Localizes to microtubule asters in prophase (PubMed:11238449). Localizes to the manchette in elongating spermatids (By similarity). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449}.
Q86VV4	reviewed	RNB3L_HUMAN	Ran-binding protein 3-like	RANBP3L	Homo sapiens (Human)	465	FUNCTION: Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner. {ECO:0000250|UniProtKB:Q6PDH4, ECO:0000269|PubMed:25755279}.		mesenchymal cell differentiation involved in bone development [GO:1901706]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of myoblast differentiation [GO:0045663]; protein export from nucleus [GO:0006611]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]	SMAD binding [GO:0046332]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; SMAD binding [GO:0046332]; mesenchymal cell differentiation involved in bone development [GO:1901706]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of myoblast differentiation [GO:0045663]; protein export from nucleus [GO:0006611]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:25755279}. Cytoplasm {ECO:0000305|PubMed:25755279}.
Q86VV8	reviewed	RTTN_HUMAN	Rotatin	RTTN	Homo sapiens (Human)	2226	FUNCTION: Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2. {ECO:0000269|PubMed:22939636}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; ciliary basal body organization [GO:0032053]; determination of left/right symmetry [GO:0007368]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; ciliary basal body organization [GO:0032053]; determination of left/right symmetry [GO:0007368]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22939636}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Note=Colocalizes with the basal bodies at the primary cilium.
Q86VW0	reviewed	SESD1_HUMAN	SEC14 domain and spectrin repeat-containing protein 1 (Huntingtin-interacting protein-like protein) (Protein Solo)	SESTD1 SOLO	Homo sapiens (Human)	696	FUNCTION: May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. {ECO:0000269|PubMed:20164195}.	MISCELLANEOUS: Called SOLO because the encoded protein is related to but shorter than DUO and TRIO.	negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]	intermediate filament cytoskeleton [GO:0045111]	phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]	intermediate filament cytoskeleton [GO:0045111]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]	
Q86VW1	reviewed	S22AG_HUMAN	Solute carrier family 22 member 16 (Carnitine transporter 2) (CT2) (Fly-like putative transporter 2) (FLIPT2) (Flipt 2) (Organic cation transporter OKB1) (Organic cation/carnitine transporter 6)	SLC22A16 OCT6	Homo sapiens (Human)	577	FUNCTION: Facilitative organic cation transporter that mediates the transport of carnitine as well as the polyamine spermidine (PubMed:12089149, PubMed:20037140). Mediates the partially Na(+)-dependent bidirectional transport of carnitine (PubMed:12089149). May mediate L-carnitine secretion from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa (PubMed:12089149). {ECO:0000269|PubMed:12089149, ECO:0000269|PubMed:20037140}.	MISCELLANEOUS: Involved in the uptake of clinically used drugs such as anticancer agents doxorubicin and bleomycin. {ECO:0000269|PubMed:15963465, ECO:0000269|PubMed:20037140}.	acid secretion [GO:0046717]; carnitine transmembrane transport [GO:1902603]; carnitine transport [GO:0015879]; cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; monoatomic ion transport [GO:0006811]; organic cation transport [GO:0015695]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; spermidine transmembrane transport [GO:1903711]	cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	amine transmembrane transporter activity [GO:0005275]; carnitine transmembrane transporter activity [GO:0015226]; organic cation transmembrane transporter activity [GO:0015101]; spermidine transmembrane transporter activity [GO:0015606]	cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; amine transmembrane transporter activity [GO:0005275]; carnitine transmembrane transporter activity [GO:0015226]; organic cation transmembrane transporter activity [GO:0015101]; spermidine transmembrane transporter activity [GO:0015606]; acid secretion [GO:0046717]; carnitine transmembrane transport [GO:1902603]; carnitine transport [GO:0015879]; cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; monoatomic ion transport [GO:0006811]; organic cation transport [GO:0015695]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; spermidine transmembrane transport [GO:1903711]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12089149, ECO:0000269|PubMed:20037140}; Multi-pass membrane protein {ECO:0000305}. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis. {ECO:0000269|PubMed:12089149}.
Q86VW2	reviewed	ARHGP_HUMAN	Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF)	ARHGEF25 GEFT	Homo sapiens (Human)	580	FUNCTION: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:11861769, ECO:0000269|PubMed:12547822, ECO:0000269|PubMed:15069594, ECO:0000269|PubMed:15632174, ECO:0000269|PubMed:16314529, ECO:0000269|PubMed:17606614}.		axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; sarcomere [GO:0030017]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; sarcomere [GO:0030017]; guanyl-nucleotide exchange factor activity [GO:0005085]; axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:11861769}. Note=Highly colocalizes with actin regions.
Q86VX9	reviewed	MON1A_HUMAN	Vacuolar fusion protein MON1 homolog A	MON1A SAND1	Homo sapiens (Human)	652	FUNCTION: Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991). {ECO:0000250|UniProtKB:Q6PDG8, ECO:0000269|PubMed:23084991}.		protein secretion [GO:0009306]; protein targeting to vacuole [GO:0006623]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; Mon1-Ccz1 complex [GO:0035658]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; Mon1-Ccz1 complex [GO:0035658]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein secretion [GO:0009306]; protein targeting to vacuole [GO:0006623]; vesicle-mediated transport [GO:0016192]	
Q86VY4	reviewed	TSYL5_HUMAN	Testis-specific Y-encoded-like protein 5 (TSPY-like protein 5)	TSPYL5 KIAA1750	Homo sapiens (Human)	417	FUNCTION: Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. {ECO:0000269|PubMed:20079711, ECO:0000269|PubMed:21170034}.		cellular response to gamma radiation [GO:0071480]; nucleosome assembly [GO:0006334]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein ubiquitination [GO:0031398]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; cellular response to gamma radiation [GO:0071480]; nucleosome assembly [GO:0006334]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein ubiquitination [GO:0031398]	
Q86VZ4	reviewed	LRP11_HUMAN	Low-density lipoprotein receptor-related protein 11 (LRP-11)	LRP11	Homo sapiens (Human)	500			multicellular organismal response to stress [GO:0033555]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to immobilization stress [GO:0035902]; response to mechanical stimulus [GO:0009612]; response to starvation [GO:0042594]; response to water deprivation [GO:0009414]	plasma membrane [GO:0005886]	phosphoprotein binding [GO:0051219]	plasma membrane [GO:0005886]; phosphoprotein binding [GO:0051219]; multicellular organismal response to stress [GO:0033555]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to immobilization stress [GO:0035902]; response to mechanical stimulus [GO:0009612]; response to starvation [GO:0042594]; response to water deprivation [GO:0009414]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q86VZ5	reviewed	SMS1_HUMAN	Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC 2.7.8.27) (Medulla oblongata-derived protein) (Protein Mob) (Sphingomyelin synthase 1) (Transmembrane protein 23)	SGMS1 MOB SMS1 TMEM23	Homo sapiens (Human)	413	FUNCTION: Major sphingomyelin synthase at the Golgi apparatus (PubMed:17449912, PubMed:14685263). Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes (PubMed:14685263, PubMed:17449912, PubMed:14976195, PubMed:17982138, PubMed:19454763). Does not use free phosphorylcholine or CDP-choline as donor (PubMed:14976195, PubMed:14685263). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:14976195, PubMed:17449912, PubMed:17982138). Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (PubMed:18370930, PubMed:21980337). {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:14976195, ECO:0000269|PubMed:17449912, ECO:0000269|PubMed:17982138, ECO:0000269|PubMed:18370930, ECO:0000269|PubMed:19454763, ECO:0000269|PubMed:21980337}.	MISCELLANEOUS: Overexpression of the human protein in mouse causes increased non-HDL-sphingomyelin and non-HDL cholesterol levels, decreased HDL-sphingomyelin and HDL-cholesterol levels and increases the atherogenic potential of non-HDL lipoprotein particles.	apoptotic process [GO:0006915]; ceramide biosynthetic process [GO:0046513]; phosphorylation [GO:0016310]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]	endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ceramide cholinephosphotransferase activity [GO:0047493]; ceramide phosphoethanolamine synthase activity [GO:0002950]; kinase activity [GO:0016301]; sphingomyelin synthase activity [GO:0033188]	endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ceramide cholinephosphotransferase activity [GO:0047493]; ceramide phosphoethanolamine synthase activity [GO:0002950]; kinase activity [GO:0016301]; sphingomyelin synthase activity [GO:0033188]; apoptotic process [GO:0006915]; ceramide biosynthetic process [GO:0046513]; phosphorylation [GO:0016310]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912, ECO:0000269|PubMed:18694848}; Multi-pass membrane protein {ECO:0000255}.
Q86VZ6	reviewed	JAZF1_HUMAN	Juxtaposed with another zinc finger protein 1 (TAK1-interacting protein 27) (Zinc finger protein 802)	JAZF1 TIP27 ZNF802	Homo sapiens (Human)	243	FUNCTION: Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity). {ECO:0000250|UniProtKB:Q80ZQ5, ECO:0000269|PubMed:15302918}.	MISCELLANEOUS: Under hypoxic conditions, the precursor SUZ12 RNA undergoes regulated trans-splicing with the JAZF1 RNA, resulting in a chimeric isoform which may be protective against apoptosis. The chimeric transcript is characterized by JAZF1 exons 1-3 joined to SUZ12 exon 2-16. The chimeric transcript is expressed primarily in the endometrium from late secretory and early proliferative phases of the menstrual cycle, but not in normal myometrium at any phase of the cycle. Its expression is slightly induced by low levels of progesterone, but suppressed by both estrogen and high levels of progesterone (PubMed:18772439). {ECO:0000305|PubMed:18772439}.	lipid metabolic process [GO:0006629]; negative regulation of transcription by RNA polymerase II [GO:0000122]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; lipid metabolic process [GO:0006629]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15302918}.
Q86W10	reviewed	CP4Z1_HUMAN	Cytochrome P450 4Z1 (EC 1.14.14.1) (CYPIVZ1) (Laurate 7-monooxygenase) (EC 1.14.14.130)	CYP4Z1 UNQ3060/PRO9882	Homo sapiens (Human)	505	FUNCTION: A cytochrome P450 monooxygenase that catalyzes the in-chain oxidation of fatty acids (PubMed:19090726, PubMed:29018033). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates lauric and myristic acids predominantly at the omega-4 and omega-2 positions, respectively (PubMed:19090726, PubMed:29018033). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Displays an absolute stereoselectivity in the epoxidation of arachidonic acid producing the 14(S),15(R)-epoxyeicosatrienoic acid (EET) enantiomer (PubMed:29018033). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:19090726, PubMed:29018033). {ECO:0000269|PubMed:19090726, ECO:0000269|PubMed:29018033}.		arachidonic acid metabolic process [GO:0019369]; lauric acid metabolic process [GO:0048252]	endoplasmic reticulum membrane [GO:0005789]	arachidonic acid 14,15-epoxygenase activity [GO:0008404]; aromatase activity [GO:0070330]; fatty acid in-chain hydroxylase activity [GO:0052722]; heme binding [GO:0020037]; iron ion binding [GO:0005506]	endoplasmic reticulum membrane [GO:0005789]; arachidonic acid 14,15-epoxygenase activity [GO:0008404]; aromatase activity [GO:0070330]; fatty acid in-chain hydroxylase activity [GO:0052722]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; arachidonic acid metabolic process [GO:0019369]; lauric acid metabolic process [GO:0048252]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15059886}; Single-pass type II membrane protein {ECO:0000269|PubMed:15059886}. Microsome membrane {ECO:0000269|PubMed:15059886}; Single-pass type II membrane protein {ECO:0000269|PubMed:15059886}.
Q86W24	reviewed	NAL14_HUMAN	NACHT, LRR and PYD domains-containing protein 14 (Nucleotide-binding oligomerization domain protein 5)	NLRP14 NALP14 NOD5	Homo sapiens (Human)	1093	FUNCTION: May be involved in inflammation and spermatogenesis.		cell differentiation [GO:0030154]; regulation of inflammatory response [GO:0050727]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; cell differentiation [GO:0030154]; regulation of inflammatory response [GO:0050727]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6B966}.
Q86W26	reviewed	NAL10_HUMAN	NACHT, LRR and PYD domains-containing protein 10 (Nucleotide-binding oligomerization domain protein 8)	NLRP10 NALP10 NOD8 PYNOD	Homo sapiens (Human)	655	FUNCTION: Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819). {ECO:0000250|UniProtKB:Q8CCN1, ECO:0000269|PubMed:15096476, ECO:0000269|PubMed:20393137, ECO:0000269|PubMed:22672233, ECO:0000269|PubMed:23861819}.		activation of innate immune response [GO:0002218]; adaptive immune response [GO:0002250]; defense response to fungus [GO:0050832]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 type immune response [GO:2000318]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; GTPase activity [GO:0003924]; activation of innate immune response [GO:0002218]; adaptive immune response [GO:0002250]; defense response to fungus [GO:0050832]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 type immune response [GO:2000318]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22672233}. Cell membrane {ECO:0000269|PubMed:22672233}; Peripheral membrane protein {ECO:0000305}. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection. {ECO:0000269|PubMed:22672233}.
Q86W42	reviewed	THOC6_HUMAN	THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)	THOC6 WDR58 PSEC0006	Homo sapiens (Human)	341	FUNCTION: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23621916}.		apoptotic process [GO:0006915]; central nervous system development [GO:0007417]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; RNA splicing [GO:0008380]; viral mRNA export from host cell nucleus [GO:0046784]	nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]	RNA binding [GO:0003723]	nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; central nervous system development [GO:0007417]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; RNA splicing [GO:0008380]; viral mRNA export from host cell nucleus [GO:0046784]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23621916}. Nucleus speckle {ECO:0000305|PubMed:23621916}.
Q86W47	reviewed	KCMB4_HUMAN	Calcium-activated potassium channel subunit beta-4 (BK channel subunit beta-4) (BKbeta4) (Hbeta4) (Calcium-activated potassium channel, subfamily M subunit beta-4) (Charybdotoxin receptor subunit beta-4) (K(VCA)beta-4) (Maxi K channel subunit beta-4) (Slo-beta-4)	KCNMB4	Homo sapiens (Human)	210	FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. {ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10792058, ECO:0000269|PubMed:10828459}.	MISCELLANEOUS: Treatment with okadaic acid reduces its effect on KCNMA1.	action potential [GO:0001508]; chemical synaptic transmission [GO:0007268]; detection of calcium ion [GO:0005513]; neuronal action potential [GO:0019228]; potassium ion transport [GO:0006813]; regulation of neurotransmitter secretion [GO:0046928]; regulation of vasoconstriction [GO:0019229]	plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]	calcium-activated potassium channel activity [GO:0015269]; potassium channel regulator activity [GO:0015459]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]	plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]; calcium-activated potassium channel activity [GO:0015269]; potassium channel regulator activity [GO:0015459]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; action potential [GO:0001508]; chemical synaptic transmission [GO:0007268]; detection of calcium ion [GO:0005513]; neuronal action potential [GO:0019228]; potassium ion transport [GO:0006813]; regulation of neurotransmitter secretion [GO:0046928]; regulation of vasoconstriction [GO:0019229]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q86W50	reviewed	MET16_HUMAN	RNA N6-adenosine-methyltransferase METTL16 (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (N6-adenosine-methyltransferase METTL16) (EC 2.1.1.348) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346)	METTL16 METT10D	Homo sapiens (Human)	562	FUNCTION: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197299, PubMed:30197297, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197299, PubMed:30197297). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}.		mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; mRNA methylation [GO:0080009]; negative regulation of 3'-UTR-mediated mRNA stabilization [GO:1905869]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of mRNA splicing, via spliceosome [GO:0048024]; rRNA base methylation [GO:0070475]; S-adenosylmethionine biosynthetic process [GO:0006556]; snRNA (adenine-N6)-methylation [GO:0120049]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	23S rRNA (adenine(1618)-N(6))-methyltransferase activity [GO:0052907]; mRNA (N6-adenosine)-methyltransferase activity [GO:0001734]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; U6 snRNA (adenine-(43)-N(6))-methyltransferase activity [GO:0120048]; U6 snRNA 3'-end binding [GO:0030629]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; 23S rRNA (adenine(1618)-N(6))-methyltransferase activity [GO:0052907]; mRNA (N6-adenosine)-methyltransferase activity [GO:0001734]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; U6 snRNA (adenine-(43)-N(6))-methyltransferase activity [GO:0120048]; U6 snRNA 3'-end binding [GO:0030629]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; mRNA methylation [GO:0080009]; negative regulation of 3'-UTR-mediated mRNA stabilization [GO:1905869]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of mRNA splicing, via spliceosome [GO:0048024]; rRNA base methylation [GO:0070475]; S-adenosylmethionine biosynthetic process [GO:0006556]; snRNA (adenine-N6)-methylation [GO:0120049]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:31940410}. Cytoplasm {ECO:0000269|PubMed:31940410}.
Q86W54	reviewed	SPA24_HUMAN	Spermatogenesis-associated protein 24 (Testis protein T6441 homolog)	SPATA24	Homo sapiens (Human)	205	FUNCTION: Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19515240}. Nucleus, nucleolus {ECO:0000269|PubMed:19515240}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19515240}. Note=Associated with chromatin. {ECO:0000250}.
Q86W56	reviewed	PARG_HUMAN	Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143)	PARG	Homo sapiens (Human)	976	FUNCTION: Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34321462, PubMed:34019811). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}.	MISCELLANEOUS: [Isoform 4]: Catalytically inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Catalytically inactive. {ECO:0000305}.	ATP generation from poly-ADP-D-ribose [GO:1990966]; base-excision repair, gap-filling [GO:0006287]; carbohydrate metabolic process [GO:0005975]; nucleotide-sugar metabolic process [GO:0009225]; regulation of DNA repair [GO:0006282]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	poly(ADP-ribose) glycohydrolase activity [GO:0004649]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; poly(ADP-ribose) glycohydrolase activity [GO:0004649]; ATP generation from poly-ADP-D-ribose [GO:1990966]; base-excision repair, gap-filling [GO:0006287]; carbohydrate metabolic process [GO:0005975]; nucleotide-sugar metabolic process [GO:0009225]; regulation of DNA repair [GO:0006282]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:16460818, ECO:0000269|PubMed:21398629}. Note=Colocalizes with PCNA at replication foci (PubMed:21398629). Relocalizes to the cytoplasm in response to DNA damage (PubMed:16460818). {ECO:0000269|PubMed:16460818, ECO:0000269|PubMed:21398629}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15212953, ECO:0000269|PubMed:16460818}. Note=Translocates to the nucleus in response to DNA damage. {ECO:0000269|PubMed:16460818}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:15212953}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:22433848}. Mitochondrion {ECO:0000269|PubMed:22433848}.; SUBCELLULAR LOCATION: [Isoform 5]: Mitochondrion matrix {ECO:0000269|PubMed:17509564}.
Q86W74	reviewed	ANR46_HUMAN	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S)	ANKRD46	Homo sapiens (Human)	228				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q86W92	reviewed	LIPB1_HUMAN	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2)	PPFIBP1 KIAA1230	Homo sapiens (Human)	1011	FUNCTION: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}.	MISCELLANEOUS: [Isoform 5]: Due to intron retention. {ECO:0000305}.	cell adhesion [GO:0007155]; neuromuscular junction development [GO:0007528]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]	cadherin binding [GO:0045296]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; cadherin binding [GO:0045296]; cell adhesion [GO:0007155]; neuromuscular junction development [GO:0007528]	
Q86WA6	reviewed	BPHL_HUMAN	Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) (Biphenyl hydrolase-related protein) (Bph-rp) (Breast epithelial mucin-associated antigen) (MCNAA)	BPHL MCNAA	Homo sapiens (Human)	291	FUNCTION: Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. {ECO:0000269|PubMed:18256025}.		amino acid metabolic process [GO:0006520]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	alpha-amino-acid esterase activity [GO:0047658]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; alpha-amino-acid esterase activity [GO:0047658]; amino acid metabolic process [GO:0006520]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805]	
Q86WA8	reviewed	LONP2_HUMAN	Lon protease homolog 2, peroxisomal (EC 3.4.21.53) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease) (pLon)	LONP2 LONP	Homo sapiens (Human)	852	FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. {ECO:0000255|HAMAP-Rule:MF_03121, ECO:0000269|PubMed:22002062}.		peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein processing [GO:0016485]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein targeting to peroxisome [GO:0006625]; regulation of fatty acid beta-oxidation [GO:0031998]; response to organic cyclic compound [GO:0014070]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; enzyme binding [GO:0019899]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; enzyme binding [GO:0019899]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein processing [GO:0016485]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein targeting to peroxisome [GO:0006625]; regulation of fatty acid beta-oxidation [GO:0031998]; response to organic cyclic compound [GO:0014070]	SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000255|HAMAP-Rule:MF_03121, ECO:0000269|PubMed:14561759, ECO:0000269|PubMed:18281296, ECO:0000269|PubMed:22002062}.
Q86WA9	reviewed	S2611_HUMAN	Sodium-independent sulfate anion transporter (Solute carrier family 26 member 11)	SLC26A11	Homo sapiens (Human)	606	FUNCTION: Sodium-independent anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport (By similarity). Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC) (PubMed:12626430). In the kidney, mediates chloride-bicarbonate exchange, facilitating V-ATPase-mediated acid secretion (By similarity). May function as a chloride channel, playing an important role in moderating chloride homeostasis and neuronal activity in the cerebellum (By similarity). {ECO:0000250|UniProtKB:G3C7W6, ECO:0000250|UniProtKB:Q80ZD3, ECO:0000269|PubMed:12626430}.		monoatomic ion transport [GO:0006811]; oxalate transport [GO:0019532]; sulfate transport [GO:0008272]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]; chloride:bicarbonate antiporter activity [GO:0140900]; monoatomic anion transmembrane transporter activity [GO:0008509]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; chloride:bicarbonate antiporter activity [GO:0140900]; monoatomic anion transmembrane transporter activity [GO:0008509]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; monoatomic ion transport [GO:0006811]; oxalate transport [GO:0019532]; sulfate transport [GO:0008272]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12626430}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:20957757}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q80ZD3}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q80ZD3}; Multi-pass membrane protein {ECO:0000255}.
Q86WB0	reviewed	ZC3C1_HUMAN	Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase)	ZC3HC1 NIPA HSPC216	Homo sapiens (Human)	502	FUNCTION: Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. {ECO:0000269|PubMed:16009132}.		cell cycle [GO:0007049]; cell division [GO:0051301]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; protein ubiquitination [GO:0016567]	nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270]	nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; cell division [GO:0051301]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12748172}.
Q86WB7	reviewed	UN93A_HUMAN	Protein unc-93 homolog A (HmUnc-93A) (Unc-93A)	UNC93A	Homo sapiens (Human)	457		MISCELLANEOUS: Although UNC93A gene is located in a region of the genome frequently associated with ovarian cancer, no evidence have been found for a tumor suppressor function.		membrane [GO:0016020]; plasma membrane [GO:0005886]		membrane [GO:0016020]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12381271}; Multi-pass membrane protein {ECO:0000269|PubMed:12381271}.
Q86WC4	reviewed	OSTM1_HUMAN	Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit)	OSTM1 GL HSPC019 UNQ6098/PRO21201	Homo sapiens (Human)	334	FUNCTION: Required for osteoclast and melanocyte maturation and function. {ECO:0000250, ECO:0000269|PubMed:21527911}.		osteoclast differentiation [GO:0030316]; transepithelial chloride transport [GO:0030321]	chloride channel complex [GO:0034707]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]		chloride channel complex [GO:0034707]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; osteoclast differentiation [GO:0030316]; transepithelial chloride transport [GO:0030321]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:21527911}; Single-pass type I membrane protein {ECO:0000269|PubMed:21527911}. Note=Requires CLCN7 to travel to lysosomes.
Q86WD7	reviewed	SPA9_HUMAN	Serpin A9 (Centerin) (Germinal center B-cell-expressed transcript 1 protein)	SERPINA9 GCET1 SERPINA11 UNQ692/PRO1337	Homo sapiens (Human)	417	FUNCTION: Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro). {ECO:0000269|PubMed:17447896}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]	serine-type endopeptidase inhibitor activity [GO:0004867]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q86WG3	reviewed	ATCAY_HUMAN	Caytaxin (Ataxia cayman type protein) (BNIP-2-homology) (BNIP-H)	ATCAY KIAA1872	Homo sapiens (Human)	371	FUNCTION: Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites. {ECO:0000269|PubMed:16899818}.		apoptotic process [GO:0006915]; mitochondrion distribution [GO:0048311]; negative regulation of glutamate metabolic process [GO:2000212]; neuron projection development [GO:0031175]; regulation of protein localization [GO:0032880]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; mitochondrial membrane [GO:0031966]; neuron projection [GO:0043005]; presynapse [GO:0098793]; synapse [GO:0045202]	kinesin binding [GO:0019894]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; mitochondrial membrane [GO:0031966]; neuron projection [GO:0043005]; presynapse [GO:0098793]; synapse [GO:0045202]; kinesin binding [GO:0019894]; apoptotic process [GO:0006915]; mitochondrion distribution [GO:0048311]; negative regulation of glutamate metabolic process [GO:2000212]; neuron projection development [GO:0031175]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000250|UniProtKB:Q1M168}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q1M168}. Presynapse {ECO:0000269|PubMed:16899818}. Mitochondrion {ECO:0000250|UniProtKB:Q1M168}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q1M168}. Cytoplasm {ECO:0000269|PubMed:16899818}.
Q86WG5	reviewed	MTMRD_HUMAN	Myotubularin-related protein 13 (Inactive phosphatidylinositol 3-phosphatase 13) (SET-binding factor 2)	SBF2 CMT4B2 KIAA1766 MTMR13	Homo sapiens (Human)	1849	FUNCTION: Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701, PubMed:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity). {ECO:0000250|UniProtKB:E9PXF8, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:25648148}.		autophagy [GO:0006914]; myelination [GO:0042552]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuolar membrane [GO:0005774]	guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; phosphatase binding [GO:0019902]; phosphatase regulator activity [GO:0019208]; phosphatidylinositol binding [GO:0035091]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuolar membrane [GO:0005774]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; phosphatase binding [GO:0019902]; phosphatase regulator activity [GO:0019208]; phosphatidylinositol binding [GO:0035091]; autophagy [GO:0006914]; myelination [GO:0042552]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15998640}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:E9PXF8}. Membrane {ECO:0000269|PubMed:15998640}; Peripheral membrane protein {ECO:0000269|PubMed:15998640}. Endosome membrane {ECO:0000250|UniProtKB:E9PXF8}; Peripheral membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:E9PXF8}. Note=Associated with membranes (PubMed:15998640). Localizes to vacuoles in hypo-osmotic conditions (By similarity). Membrane localization is likely to be mediated via its interaction with MTMR2 (By similarity). {ECO:0000250|UniProtKB:E9PXF8, ECO:0000269|PubMed:15998640}.
Q86WH2	reviewed	RASF3_HUMAN	Ras association domain-containing protein 3	RASSF3	Homo sapiens (Human)	238			signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15569673}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15569673}. Note=Localized to microtubules in vascular endothelial cells.
Q86WI1	reviewed	PKHL1_HUMAN	Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1)	PKHD1L1	Homo sapiens (Human)	4243			immune response [GO:0006955]; sensory perception of sound [GO:0007605]	cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; stereocilium coat [GO:0120234]; stereocilium tip [GO:0032426]	signaling receptor activity [GO:0038023]	cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; stereocilium coat [GO:0120234]; stereocilium tip [GO:0032426]; signaling receptor activity [GO:0038023]; immune response [GO:0006955]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q86WI3	reviewed	NLRC5_HUMAN	Protein NLRC5 (Caterpiller protein 16.1) (CLR16.1) (Nucleotide-binding oligomerization domain protein 27) (Nucleotide-binding oligomerization domain protein 4)	NLRC5 NOD27 NOD4	Homo sapiens (Human)	1866	FUNCTION: Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. {ECO:0000269|PubMed:20061403, ECO:0000269|PubMed:20434986}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	defense response to virus [GO:0051607]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; regulation of kinase activity [GO:0043549]; response to bacterium [GO:0009617]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; regulation of kinase activity [GO:0043549]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20061403, ECO:0000269|PubMed:20434986}.
Q86WJ1	reviewed	CHD1L_HUMAN	Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1)	CHD1L ALC1	Homo sapiens (Human)	897	FUNCTION: ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:33357431, PubMed:34486521, PubMed:34874266, PubMed:34210977). Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34874266, PubMed:34486521). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34874266, PubMed:34486521). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed:19661379, PubMed:29220652, PubMed:29220653). Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed:33275888). {ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:29220652, ECO:0000269|PubMed:29220653, ECO:0000269|PubMed:33275888, ECO:0000269|PubMed:33357431, ECO:0000269|PubMed:34210977, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34874266}.		chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA helicase activity [GO:0003678]; histone reader activity [GO:0140566]; nucleosome binding [GO:0031491]; nucleotide binding [GO:0000166]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA helicase activity [GO:0003678]; histone reader activity [GO:0140566]; nucleosome binding [GO:0031491]; nucleotide binding [GO:0000166]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19661379}. Chromosome {ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:29220652, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34874266}. Note=Localizes at sites of DNA damage; recruited by histones H2B and H3 poly-ADP-ribosylated on 'Ser-6' and 'Ser-10', respectively (H2BS6ADPr and H3S10ADPr) by PARP1 or PARP2. {ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34874266}.
Q86WK6	reviewed	AMGO1_HUMAN	Amphoterin-induced protein 1 (AMIGO-1) (Alivin-2)	AMIGO1 ALI2 AMIGO KIAA1163	Homo sapiens (Human)	493	FUNCTION: Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:Q80ZD7, ECO:0000250|UniProtKB:Q80ZD8}.		axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; brain development [GO:0007420]; cellular response to L-glutamate [GO:1905232]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; myelination [GO:0042552]; positive regulation of axonogenesis [GO:0050772]; positive regulation of neuron projection development [GO:0010976]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of synapse assembly [GO:0051965]	dendrite [GO:0030425]; neuronal cell body membrane [GO:0032809]; pericellular basket [GO:1990030]; perikaryon [GO:0043204]; voltage-gated potassium channel complex [GO:0008076]	potassium channel regulator activity [GO:0015459]	dendrite [GO:0030425]; neuronal cell body membrane [GO:0032809]; pericellular basket [GO:1990030]; perikaryon [GO:0043204]; voltage-gated potassium channel complex [GO:0008076]; potassium channel regulator activity [GO:0015459]; axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; brain development [GO:0007420]; cellular response to L-glutamate [GO:1905232]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; myelination [GO:0042552]; positive regulation of axonogenesis [GO:0050772]; positive regulation of neuron projection development [GO:0010976]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of synapse assembly [GO:0051965]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80ZD8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q80ZD8}. Perikaryon {ECO:0000250|UniProtKB:Q80ZD8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q80ZD8}. Cell projection, axon {ECO:0000250|UniProtKB:Q80ZD7}. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons. Associated with axons of neuronal cells. {ECO:0000250|UniProtKB:Q80ZD7, ECO:0000250|UniProtKB:Q80ZD8}.
Q86WN1	reviewed	FCSD1_HUMAN	F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2)	FCHSD1 UNQ737/PRO1431	Homo sapiens (Human)	690	FUNCTION: Promotes actin polymerization mediated by SNX9 and WASL. {ECO:0000250|UniProtKB:Q6PFY1}.		membrane organization [GO:0061024]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of actin filament polymerization [GO:0030838]; regulation of actin filament polymerization [GO:0030833]	cell projection [GO:0042995]; cuticular plate [GO:0032437]; neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; recycling endosome [GO:0055037]	lipid binding [GO:0008289]	cell projection [GO:0042995]; cuticular plate [GO:0032437]; neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; recycling endosome [GO:0055037]; lipid binding [GO:0008289]; membrane organization [GO:0061024]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of actin filament polymerization [GO:0030838]; regulation of actin filament polymerization [GO:0030833]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6PFY1}. Perikaryon {ECO:0000250|UniProtKB:Q6PFY1}. Cell projection {ECO:0000250|UniProtKB:Q6PFY1}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q6PFY1}. Note=Detected on neuronal cell bodies and cell projections, in part on cytoplasmic vesicles. {ECO:0000250|UniProtKB:Q6PFY1}.
Q86WP2	reviewed	GPBP1_HUMAN	Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein)	GPBP1 GPBP SSH6	Homo sapiens (Human)	473	FUNCTION: Functions as a GC-rich promoter-specific transactivating transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}.		DNA-templated transcription [GO:0006351]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; RNA binding [GO:0003723]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; RNA binding [GO:0003723]; DNA-templated transcription [GO:0006351]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14612417}. Cytoplasm {ECO:0000269|PubMed:12842993}. Note=According to PubMed:12842993, it localizes to the cytoplasm. {ECO:0000269|PubMed:12842993}.
Q86WQ0	reviewed	NR2CA_HUMAN	Nuclear receptor 2C2-associated protein (TR4 orphan receptor-associated 16 kDa protein)	NR2C2AP TRA16	Homo sapiens (Human)	139	FUNCTION: May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes. {ECO:0000269|PubMed:12486131}.			nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12486131}.
Q86WR0	reviewed	CCD25_HUMAN	Coiled-coil domain-containing protein 25	CCDC25	Homo sapiens (Human)	208	FUNCTION: Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174). {ECO:0000269|PubMed:32528174}.		positive regulation of cell motility [GO:2000147]	endomembrane system [GO:0012505]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]	endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; positive regulation of cell motility [GO:2000147]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32528174}; Single-pass membrane protein {ECO:0000305|PubMed:32528174}. Endomembrane system {ECO:0000269|PubMed:32528174}. Note=Localizes to cytoplasmic membrane in tumor cells. {ECO:0000269|PubMed:32528174}.
Q86WS5	reviewed	TMPSC_HUMAN	Transmembrane protease serine 12 (EC 3.4.21.-)	TMPRSS12	Homo sapiens (Human)	348	FUNCTION: Required for male fertility (By similarity). Plays a critical role in sperm capacitation and acrosome reactions during fertilization, and also plays a role in the regulation of proteins involved in spermatogenesis (By similarity). Regulates protein pathways that promote chromosomal synapsis formation, double-strand break repair, formation of the inner mitochondrial membrane cristae and apoptosis in developing sperm (By similarity). Required for normal sperm motility and binding to the zona pellucida, potentially via a role in ADAM3 protein maturation (By similarity). {ECO:0000250|UniProtKB:Q3V0Q7}.	MISCELLANEOUS: Expressed in colorectal cancer (at protein level). {ECO:0000269|PubMed:23436708}.	binding of sperm to zona pellucida [GO:0007339]; cell differentiation [GO:0030154]; protein processing [GO:0016485]; spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]	acrosomal vesicle [GO:0001669]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; binding of sperm to zona pellucida [GO:0007339]; cell differentiation [GO:0030154]; protein processing [GO:0016485]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23436708}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q3V0Q7}. Note=Expression in the acrosome decreases after acrosome reaction. {ECO:0000250|UniProtKB:Q3V0Q7}.
Q86WT6	reviewed	TRI69_HUMAN	E3 ubiquitin-protein ligase TRIM69 (EC 2.3.2.27) (RFP-like domain-containing protein trimless) (RING finger protein 36) (RING-type E3 ubiquitin transferase TRIM69) (Tripartite motif-containing protein 69)	TRIM69 RNF36 HSD-34 HSD34	Homo sapiens (Human)	500	FUNCTION: E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus (PubMed:23131556, PubMed:30142214, PubMed:31375575, PubMed:31578292). Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection (PubMed:30844644). In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity (PubMed:36251989). Plays also a role in cataract formation together with TP53 (PubMed:30844644). Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination (PubMed:30844644). {ECO:0000269|PubMed:23131556, ECO:0000269|PubMed:30142214, ECO:0000269|PubMed:30844644, ECO:0000269|PubMed:31375575, ECO:0000269|PubMed:31578292, ECO:0000269|PubMed:36251989}.		apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23131556, ECO:0000269|PubMed:31578292, ECO:0000269|PubMed:36251989}. Nucleus {ECO:0000269|PubMed:23131556}. Nucleus speckle {ECO:0000269|PubMed:23131556}. Note=Adopts a filamentous distribution in the cell cytoplasm where it strongly colocalizes with stable microtubules. {ECO:0000269|PubMed:36251989}.
Q86WU2	reviewed	LDHD_HUMAN	Probable D-lactate dehydrogenase, mitochondrial (DLD) (Lactate dehydrogenase D) (EC 1.1.2.4)	LDHD	Homo sapiens (Human)	507	FUNCTION: Involved in D-lactate, but not L-lactate catabolic process. {ECO:0000269|PubMed:30931947}.		lactate catabolic process [GO:1903457]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	D-lactate dehydrogenase (cytochrome) activity [GO:0004458]; D-lactate dehydrogenase activity [GO:0008720]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; D-lactate dehydrogenase (cytochrome) activity [GO:0004458]; D-lactate dehydrogenase activity [GO:0008720]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; lactate catabolic process [GO:1903457]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q7TNG8}.
Q86WV1	reviewed	SKAP1_HUMAN	Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55)	SKAP1 SCAP1 SKAP55	Homo sapiens (Human)	359	FUNCTION: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. {ECO:0000269|PubMed:10856234, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296, ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}.		adaptive immune response [GO:0002250]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of integrin activation [GO:0033625]; positive regulation of leukocyte cell-cell adhesion [GO:1903039]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; T cell receptor signaling pathway [GO:0050852]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; T cell receptor complex [GO:0042101]	protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; T cell receptor complex [GO:0042101]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; adaptive immune response [GO:0002250]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of integrin activation [GO:0033625]; positive regulation of leukocyte cell-cell adhesion [GO:1903039]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:9671755}. Nucleus {ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:9671755}. Cell membrane {ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:9671755}. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. {ECO:0000269|PubMed:9671755}.
Q86WV5	reviewed	TEN1L_HUMAN	CST complex subunit TEN1 (Protein telomeric pathways with STN1 homolog) (Telomere length regulation protein TEN1 homolog)	TEN1 C17orf106	Homo sapiens (Human)	123	FUNCTION: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). {ECO:0000269|PubMed:19854130, ECO:0000269|PubMed:22763445, ECO:0000269|PubMed:25483097}.		negative regulation of telomere maintenance via telomerase [GO:0032211]; telomere capping [GO:0016233]	chromosome, telomeric region [GO:0000781]; CST complex [GO:1990879]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	single-stranded DNA binding [GO:0003697]; telomerase inhibitor activity [GO:0010521]; telomeric DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; CST complex [GO:1990879]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; single-stranded DNA binding [GO:0003697]; telomerase inhibitor activity [GO:0010521]; telomeric DNA binding [GO:0042162]; negative regulation of telomere maintenance via telomerase [GO:0032211]; telomere capping [GO:0016233]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19854130}. Chromosome, telomere {ECO:0000269|PubMed:19854130}.
Q86WV6	reviewed	STING_HUMAN	Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)	STING1 ERIS MITA STING TMEM173	Homo sapiens (Human)	379	FUNCTION: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23910378, PubMed:23747010, PubMed:29973723, PubMed:30842659, PubMed:35045565, PubMed:27801882, PubMed:36808561). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (PubMed:26300263). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (PubMed:21947006, PubMed:23258412, PubMed:23707065, PubMed:23722158, PubMed:26229117, PubMed:23910378, PubMed:23747010, PubMed:30842659). Upon binding of c-di-GMP or cGAMP, STING1 oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state (PubMed:22394562, PubMed:25636800, PubMed:29973723, PubMed:30842653, PubMed:35045565). In addition to promote the production of type I interferons, plays a direct role in autophagy (PubMed:30568238, PubMed:30842662). Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (PubMed:30842662). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (PubMed:30842662). The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (PubMed:30568238, PubMed:30842662). Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy (By similarity). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263, PubMed:23910378, PubMed:23747010). The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, whichs adopts an organized free-ligand conformation that resembles the STING1-bound conformation and pays low energy costs in changing into the active conformation (PubMed:26150511). May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons (PubMed:18724357). May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) (By similarity). {ECO:0000250|UniProtKB:Q3TBT3, ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:19776740, ECO:0000269|PubMed:21947006, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:23258412, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722158, ECO:0000269|PubMed:23747010, ECO:0000269|PubMed:23910378, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26150511, ECO:0000269|PubMed:26229117, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29973723, ECO:0000269|PubMed:30568238, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:30842659, ECO:0000269|PubMed:30842662, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:36808561}.; FUNCTION: (Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed:26405230). Such oncoproteins prevent the ability to sense cytosolic DNA (PubMed:26405230). {ECO:0000269|PubMed:26405230}.	MISCELLANEOUS: The cGAS-STING signaling pathway drives sterile inflammation leading to type I interferon immunopathology in severe COVID-19 disease caused by SARS-CoV-2 virus infection (PubMed:35045565). Tissue damages in the lung and skin lesions are caused by activation of the cGAS-STING signaling leading to aberrant inflammation (PubMed:35045565). Endothelial cell damage is also caused by activation of the cGAS-STING pathway: SARS-CoV-2 infection triggers mitochondrial DNA release into the cytosol (PubMed:35045565). Released mitochondrial DNA is then detected by CGAS, leading to activation of the cGAS-STING pathway, triggering type-I interferon production and autoinflammation (PubMed:35045565). {ECO:0000269|PubMed:35045565}.	activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; autophagosome assembly [GO:0000045]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein complex oligomerization [GO:0051259]; regulation of inflammatory response [GO:0050727]; reticulophagy [GO:0061709]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; serine/threonine protein kinase complex [GO:1902554]; STING complex [GO:1990231]	2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling adaptor activity [GO:0035591]; ubiquitin protein ligase binding [GO:0031625]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; serine/threonine protein kinase complex [GO:1902554]; STING complex [GO:1990231]; 2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling adaptor activity [GO:0035591]; ubiquitin protein ligase binding [GO:0031625]; activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; autophagosome assembly [GO:0000045]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein complex oligomerization [GO:0051259]; regulation of inflammatory response [GO:0050727]; reticulophagy [GO:0061709]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:19285439, ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:19776740, ECO:0000269|PubMed:25254379, ECO:0000269|PubMed:29694889, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:30842659, ECO:0000269|PubMed:32690950}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:30842659, ECO:0000269|PubMed:32690950}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:29694889, ECO:0000269|PubMed:30842653}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:30842662, ECO:0000269|PubMed:32690950}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:32690950}. Golgi apparatus membrane {ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:34903048, ECO:0000269|PubMed:36808561}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:30842662}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:19285439, ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:19776740}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q3TBT3}; Multi-pass membrane protein {ECO:0000255}. Note=In response to double-stranded DNA stimulation, translocates from the endoplasmic reticulum through the endoplasmic reticulum-Golgi intermediate compartment and Golgi to post-Golgi vesicles, where the kinase TBK1 is recruited (PubMed:19433799, PubMed:30842659, PubMed:30842653, PubMed:29694889). Upon cGAMP-binding, translocates to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) in a process that is dependent on COPII vesicles; STING1-containing ERGIC serves as a membrane source for LC3 lipidation, which is a key step in autophagosome biogenesis (PubMed:30842662). {ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:29694889, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:30842659, ECO:0000269|PubMed:30842662, ECO:0000269|PubMed:32690950}.
Q86WX3	reviewed	AROS_HUMAN	Active regulator of SIRT1 (40S ribosomal protein S19-binding protein 1) (RPS19-binding protein 1) (S19BP)	RPS19BP1 AROS	Homo sapiens (Human)	136	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1 (PubMed:34516797). Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (PubMed:17964266). {ECO:0000269|PubMed:17964266, ECO:0000269|PubMed:34516797}.		ribosomal small subunit biogenesis [GO:0042274]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	enzyme binding [GO:0019899]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; enzyme binding [GO:0019899]; RNA binding [GO:0003723]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:17964266, ECO:0000269|PubMed:34516797}.
Q86X02	reviewed	CDR2L_HUMAN	Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen)	CDR2L HUMPPA	Homo sapiens (Human)	465			Golgi to secretory granule transport [GO:0055107]; vesicle transport along microtubule [GO:0047496]	cytoplasm [GO:0005737]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; Golgi to secretory granule transport [GO:0055107]; vesicle transport along microtubule [GO:0047496]	
Q86X24	reviewed	HORM1_HUMAN	HORMA domain-containing protein 1 (Cancer/testis antigen 46) (CT46) (Newborn ovary HORMA protein)	HORMAD1 NOHMA	Homo sapiens (Human)	394	FUNCTION: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. {ECO:0000250|UniProtKB:Q9D5T7}.		blastocyst development [GO:0001824]; meiotic cell cycle [GO:0051321]; meiotic DNA double-strand break formation [GO:0042138]; meiotic recombination checkpoint signaling [GO:0051598]; meiotic sister chromatid cohesion [GO:0051177]; oogenesis [GO:0048477]; regulation of homologous chromosome segregation [GO:0060629]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	chromosome [GO:0005694]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]		chromosome [GO:0005694]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]; blastocyst development [GO:0001824]; meiotic cell cycle [GO:0051321]; meiotic DNA double-strand break formation [GO:0042138]; meiotic recombination checkpoint signaling [GO:0051598]; meiotic sister chromatid cohesion [GO:0051177]; oogenesis [GO:0048477]; regulation of homologous chromosome segregation [GO:0060629]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D5T7}. Chromosome {ECO:0000250|UniProtKB:Q9D5T7}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity). {ECO:0000250|UniProtKB:Q9D5T7}.
Q86X29	reviewed	LSR_HUMAN	Lipolysis-stimulated lipoprotein receptor (Angulin-1)	LSR ILDR3 LISCH	Homo sapiens (Human)	649	FUNCTION: Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}.		epithelial structure maintenance [GO:0010669]; establishment of blood-brain barrier [GO:0060856]; establishment of skin barrier [GO:0061436]; liver development [GO:0001889]; maintenance of blood-brain barrier [GO:0035633]; protein localization to tricellular tight junction [GO:0061833]; tricellular tight junction assembly [GO:1904274]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; chylomicron [GO:0042627]; extracellular exosome [GO:0070062]; low-density lipoprotein particle [GO:0034362]; plasma membrane [GO:0005886]; tight junction [GO:0070160]; tricellular tight junction [GO:0061689]; very-low-density lipoprotein particle [GO:0034361]		bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; chylomicron [GO:0042627]; extracellular exosome [GO:0070062]; low-density lipoprotein particle [GO:0034362]; plasma membrane [GO:0005886]; tight junction [GO:0070160]; tricellular tight junction [GO:0061689]; very-low-density lipoprotein particle [GO:0034361]; epithelial structure maintenance [GO:0010669]; establishment of blood-brain barrier [GO:0060856]; establishment of skin barrier [GO:0061436]; liver development [GO:0001889]; maintenance of blood-brain barrier [GO:0035633]; protein localization to tricellular tight junction [GO:0061833]; tricellular tight junction assembly [GO:1904274]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21245199}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:21245199, ECO:0000269|PubMed:23239027}. Note=Located at tricellular contacts. {ECO:0000269|PubMed:21245199}.
Q86X45	reviewed	DAA11_HUMAN	Dynein axonemal assembly factor 11 (DNAAF11) (Leucine-rich repeat-containing protein 6) (Leucine-rich testis-specific protein) (Protein tilB homolog) (Testis-specific leucine-rich repeat protein)	DNAAF11 LRRC6 LRTP TSLRP	Homo sapiens (Human)	466	FUNCTION: Involved in dynein arm assembly, is important for expression and transporting outer dynein arm (ODA) proteins from the cytoplasm to the cilia (PubMed:23122589, PubMed:23527195, PubMed:33403504). Acts as a crucial component in the formation and motility of spermatozoal flagella (PubMed:33403504). {ECO:0000269|PubMed:23122589, ECO:0000269|PubMed:23527195, ECO:0000269|PubMed:33403504}.		axonemal dynein complex assembly [GO:0070286]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; male gonad development [GO:0008584]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; protein localization to cilium [GO:0061512]; protein localization to motile cilium [GO:0120229]; reproductive system development [GO:0061458]	apical cytoplasm [GO:0090651]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; motile cilium [GO:0031514]		apical cytoplasm [GO:0090651]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; axonemal dynein complex assembly [GO:0070286]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; male gonad development [GO:0008584]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; protein localization to cilium [GO:0061512]; protein localization to motile cilium [GO:0120229]; reproductive system development [GO:0061458]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23122589, ECO:0000269|PubMed:23527195, ECO:0000269|PubMed:33403504}. Cell projection, cilium {ECO:0000269|PubMed:23122589}. Dynein axonemal particle {ECO:0000250|UniProtKB:A0A1L8G016}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:33403504}.
Q86X51	reviewed	EZHIP_HUMAN	EZH inhibitory protein	EZHIP CXorf67	Homo sapiens (Human)	503	FUNCTION: Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:31086175, PubMed:31451685, PubMed:30923826). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}.		chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone methyltransferase inhibitor activity [GO:0180000]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone methyltransferase inhibitor activity [GO:0180000]; chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175}. Cytoplasm {ECO:0000269|PubMed:30923826}.
Q86X52	reviewed	CHSS1_HUMAN	Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1)	CHSY1 CHSY CSS1 KIAA0990 UNQ756/PRO1487	Homo sapiens (Human)	802	FUNCTION: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. {ECO:0000269|PubMed:11514575, ECO:0000269|PubMed:12716890, ECO:0000269|PubMed:21129727}.		bone morphogenesis [GO:0060349]; chondrocyte development [GO:0002063]; chondroitin sulfate biosynthetic process [GO:0030206]; negative regulation of ossification [GO:0030279]; positive regulation of smoothened signaling pathway [GO:0045880]; proximal/distal pattern formation [GO:0009954]; response to nutrient levels [GO:0031667]; sulfation [GO:0051923]	extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510]	extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510]; bone morphogenesis [GO:0060349]; chondrocyte development [GO:0002063]; chondroitin sulfate biosynthetic process [GO:0030206]; negative regulation of ossification [GO:0030279]; positive regulation of smoothened signaling pathway [GO:0045880]; proximal/distal pattern formation [GO:0009954]; response to nutrient levels [GO:0031667]; sulfation [GO:0051923]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:11514575}; Single-pass type II membrane protein {ECO:0000305|PubMed:11514575}. Secreted {ECO:0000269|PubMed:21129727}.
Q86X55	reviewed	CARM1_HUMAN	Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4)	CARM1 PRMT4	Homo sapiens (Human)	608	FUNCTION: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability (PubMed:12237300, PubMed:16497732, PubMed:19405910). Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activates transcription via chromatin remodeling (PubMed:12237300, PubMed:16497732, PubMed:19405910). During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription (By similarity). During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C (By similarity). During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B (By similarity). Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue (By similarity). Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors (By similarity). Also seems to be involved in p53/TP53 transcriptional activation (By similarity). Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation (PubMed:15731352). Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs (By similarity). Acts as a transcriptional coactivator of ACACA/acetyl-CoA carboxylase by enriching H3R17 methylation at its promoter, thereby positively regulating fatty acid synthesis (By similarity). Independently of its methyltransferase activity, involved in replication fork progression: promotes PARP1 recruitment to replication forks, leading to poly-ADP-ribosylation of chromatin at replication forks and reduced fork speed (PubMed:33412112). {ECO:0000250|UniProtKB:Q9WVG6, ECO:0000269|PubMed:12237300, ECO:0000269|PubMed:15731352, ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:19405910, ECO:0000269|PubMed:33412112}.		histone methylation [GO:0016571]; negative regulation of dendrite development [GO:2000171]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of DNA-templated transcription [GO:0006355]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; replication fork reversal [GO:0071932]; response to cAMP [GO:0051591]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	beta-catenin binding [GO:0008013]; DNA-binding transcription factor binding [GO:0140297]; histone arginine N-methyltransferase activity [GO:0008469]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone methyltransferase activity [GO:0042054]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor coactivator activity [GO:0030374]; protein methyltransferase activity [GO:0008276]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; beta-catenin binding [GO:0008013]; DNA-binding transcription factor binding [GO:0140297]; histone arginine N-methyltransferase activity [GO:0008469]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone methyltransferase activity [GO:0042054]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor coactivator activity [GO:0030374]; protein methyltransferase activity [GO:0008276]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; histone methylation [GO:0016571]; negative regulation of dendrite development [GO:2000171]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of DNA-templated transcription [GO:0006355]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; replication fork reversal [GO:0071932]; response to cAMP [GO:0051591]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19843527}. Cytoplasm {ECO:0000269|PubMed:19843527}. Chromosome {ECO:0000269|PubMed:33412112}. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle (PubMed:19843527). Cytoplasmic during mitosis, after breakup of the nuclear membrane (PubMed:19843527). Localizes to replication forks (PubMed:33412112). {ECO:0000269|PubMed:19843527, ECO:0000269|PubMed:33412112}.
Q86X67	reviewed	NUD13_HUMAN	NAD(P)H pyrophosphatase NUDT13, mitochondrial (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 13) (Nudix motif 13) (Protein KiSS-16)	NUDT13	Homo sapiens (Human)	352	FUNCTION: NAD(P)H pyrophosphatase that hydrolyzes NADH into NMNH and AMP, and NADPH into NMNH and 2',5'-ADP. Has a marked preference for the reduced pyridine nucleotides. Does not show activity toward NAD-capped RNAs; the NAD-cap is an atypical cap present at the 5'-end of some RNAs. {ECO:0000250|UniProtKB:Q8JZU0}.		NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742]; nucleobase-containing small molecule interconversion [GO:0015949]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	metal ion binding [GO:0046872]; NAD+ diphosphatase activity [GO:0000210]; NADH pyrophosphatase activity [GO:0035529]; pyrophosphatase activity [GO:0016462]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; NAD+ diphosphatase activity [GO:0000210]; NADH pyrophosphatase activity [GO:0035529]; pyrophosphatase activity [GO:0016462]; NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742]; nucleobase-containing small molecule interconversion [GO:0015949]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8JZU0}.
Q86X95	reviewed	CIR1_HUMAN	Corepressor interacting with RBPJ 1 (CBF1-interacting corepressor) (Recepin)	CIR1 CIR	Homo sapiens (Human)	450	FUNCTION: May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. {ECO:0000250, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:9874765}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	histone deacetylase binding [GO:0042826]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; histone deacetylase binding [GO:0042826]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
Q86XA0	reviewed	MET23_HUMAN	Histone-arginine methyltransferase METTL23 (EC 2.1.1.319) (Methyltransferase-like protein 23)	METTL23 C17orf95	Homo sapiens (Human)	190	FUNCTION: Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (By similarity). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (By similarity). {ECO:0000250|UniProtKB:A2AA28}.		cognition [GO:0050890]; epigenetic programing of male pronucleus [GO:0044727]; epigenetic programming in the zygotic pronuclei [GO:0044725]; methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA-binding transcription factor binding [GO:0140297]; heat shock protein binding [GO:0031072]; histone H3R17 methyltransferase activity [GO:0035642]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]	cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA-binding transcription factor binding [GO:0140297]; heat shock protein binding [GO:0031072]; histone H3R17 methyltransferase activity [GO:0035642]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; cognition [GO:0050890]; epigenetic programing of male pronucleus [GO:0044727]; epigenetic programming in the zygotic pronuclei [GO:0044725]; methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24501276}. Cytoplasm {ECO:0000269|PubMed:23349634, ECO:0000269|PubMed:24501276}. Note=Localizes in male and female zygote pronucleus and cytoplasm. {ECO:0000250|UniProtKB:A2AA28}.
Q86XE0	reviewed	SNX32_HUMAN	Sorting nexin-32 (Sorting nexin-6B)	SNX32 SNX6B	Homo sapiens (Human)	403	FUNCTION: May be involved in several stages of intracellular trafficking. {ECO:0000250}.		protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; endosome [GO:0005768]	phosphatidylinositol binding [GO:0035091]	cytosol [GO:0005829]; endosome [GO:0005768]; phosphatidylinositol binding [GO:0035091]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]	
Q86XE5	reviewed	HOGA1_HUMAN	4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC 4.1.3.16) (Dihydrodipicolinate synthase-like) (DHDPS-like protein) (Probable 2-keto-4-hydroxyglutarate aldolase) (Probable KHG-aldolase) (Protein 569272)	HOGA1 C10orf65 DHDPSL	Homo sapiens (Human)	327	FUNCTION: Catalyzes the final step in the metabolic pathway of hydroxyproline. {ECO:0000269|PubMed:20797690, ECO:0000269|PubMed:21998747}.		4-hydroxyproline catabolic process [GO:0019470]; glyoxylate catabolic process [GO:0009436]; glyoxylate metabolic process [GO:0046487]; N-acetylneuraminate catabolic process [GO:0019262]; oxalate metabolic process [GO:0033609]; pyruvate biosynthetic process [GO:0042866]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	(4S)-4-hydroxy-2-oxoglutarate aldolase activity [GO:0106009]; 4-hydroxy-2-oxoglutarate aldolase activity [GO:0008700]; N-acetylneuraminate lyase activity [GO:0008747]; protein homodimerization activity [GO:0042803]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; (4S)-4-hydroxy-2-oxoglutarate aldolase activity [GO:0106009]; 4-hydroxy-2-oxoglutarate aldolase activity [GO:0008700]; N-acetylneuraminate lyase activity [GO:0008747]; protein homodimerization activity [GO:0042803]; 4-hydroxyproline catabolic process [GO:0019470]; glyoxylate catabolic process [GO:0009436]; glyoxylate metabolic process [GO:0046487]; N-acetylneuraminate catabolic process [GO:0019262]; oxalate metabolic process [GO:0033609]; pyruvate biosynthetic process [GO:0042866]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q0P5I5}.
Q86XF0	reviewed	DYR2_HUMAN	Dihydrofolate reductase 2, mitochondrial (Dihydrofolate reductase, mitochondrial) (EC 1.5.1.3) (Dihydrofolate reductase-like protein 1)	DHFR2 DHFRL1 DHFRP4	Homo sapiens (Human)	187	FUNCTION: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR. {ECO:0000269|PubMed:21876184, ECO:0000269|PubMed:21876188}.	MISCELLANEOUS: Humans have acquired two dihydrofolate reductase enzymes during their evolution, DHFR and DHFR2. In contrast to human, mice and brown rats have just one. {ECO:0000269|PubMed:25980602}.	dihydrofolate metabolic process [GO:0046452]; folic acid metabolic process [GO:0046655]; glycine biosynthetic process [GO:0006545]; one-carbon metabolic process [GO:0006730]; tetrahydrofolate biosynthetic process [GO:0046654]; tetrahydrofolate metabolic process [GO:0046653]; thymidine biosynthetic process [GO:0046105]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	dihydrofolate reductase activity [GO:0004146]; folate reductase activity [GO:0033560]; mRNA binding [GO:0003729]; NADP binding [GO:0050661]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; dihydrofolate reductase activity [GO:0004146]; folate reductase activity [GO:0033560]; mRNA binding [GO:0003729]; NADP binding [GO:0050661]; dihydrofolate metabolic process [GO:0046452]; folic acid metabolic process [GO:0046655]; glycine biosynthetic process [GO:0006545]; one-carbon metabolic process [GO:0006730]; tetrahydrofolate biosynthetic process [GO:0046654]; tetrahydrofolate metabolic process [GO:0046653]; thymidine biosynthetic process [GO:0046105]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21876184, ECO:0000269|PubMed:21876188}. Mitochondrion matrix {ECO:0000269|PubMed:21876188}. Mitochondrion inner membrane {ECO:0000269|PubMed:21876188}.
Q86XF7	reviewed	ZN575_HUMAN	Zinc finger protein 575	ZNF575	Homo sapiens (Human)	245	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86XI2	reviewed	CNDG2_HUMAN	Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (hCAP-G2) (Leucine zipper protein 5) (Non-SMC condensin II complex subunit G2)	NCAPG2 LUZP5	Homo sapiens (Human)	1143	FUNCTION: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:30609410}.		cell division [GO:0051301]; chromosome condensation [GO:0030261]; erythrocyte differentiation [GO:0030218]; inner cell mass cell proliferation [GO:0001833]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; transcription by RNA polymerase II [GO:0006366]	condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	bHLH transcription factor binding [GO:0043425]; methylated histone binding [GO:0035064]	condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; bHLH transcription factor binding [GO:0043425]; methylated histone binding [GO:0035064]; cell division [GO:0051301]; chromosome condensation [GO:0030261]; erythrocyte differentiation [GO:0030218]; inner cell mass cell proliferation [GO:0001833]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14532007}.
Q86XJ1	reviewed	GA2L3_HUMAN	GAS2-like protein 3 (Growth arrest-specific protein 2-like 3)	GAS2L3	Homo sapiens (Human)	694	FUNCTION: Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}.		actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; microtubule cytoskeleton organization [GO:0000226]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017]; actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; microtubule cytoskeleton organization [GO:0000226]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21561867}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21561867, ECO:0000269|PubMed:24706950}. Note=Localizes to microtubule and actin cytoskeletons. {ECO:0000269|PubMed:21561867, ECO:0000269|PubMed:24706950}.
Q86XK2	reviewed	FBX11_HUMAN	F-box only protein 11 (Protein arginine N-methyltransferase 9) (Vitiligo-associated protein 1) (VIT-1)	FBXO11 FBX11 PRMT9 VIT1 UG063H01	Homo sapiens (Human)	927	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis. Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks (PubMed:33156908). Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta (PubMed:33156908). Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome (PubMed:37279268). Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis. Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1 (PubMed:36897010). {ECO:0000269|PubMed:17098746, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23892434, ECO:0000269|PubMed:24613396, ECO:0000269|PubMed:33156908, ECO:0000269|PubMed:36897010, ECO:0000269|PubMed:37279268}.		protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; sensory perception of sound [GO:0007605]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	protein-arginine N-methyltransferase activity [GO:0016274]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; protein-arginine N-methyltransferase activity [GO:0016274]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; sensory perception of sound [GO:0007605]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q86XK3	reviewed	SFR1_HUMAN	Swi5-dependent recombination DNA repair protein 1 homolog (Meiosis protein 5 homolog)	SFR1 C10orf78 MEI5 MEIR5	Homo sapiens (Human)	245	FUNCTION: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). {ECO:0000269|PubMed:21252223, ECO:0000269|PubMed:23874500}.		cellular response to estrogen stimulus [GO:0071391]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of DNA-templated transcription [GO:0045893]	centrosome [GO:0005813]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Swi5-Sfr1 complex [GO:0032798]	nuclear receptor coactivator activity [GO:0030374]	centrosome [GO:0005813]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Swi5-Sfr1 complex [GO:0032798]; nuclear receptor coactivator activity [GO:0030374]; cellular response to estrogen stimulus [GO:0071391]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of DNA-templated transcription [GO:0045893]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23874500}. Note=Colocalizes with ESR1 in the nucleus. {ECO:0000269|PubMed:23874500}.
Q86XK7	reviewed	VSIG1_HUMAN	V-set and immunoglobulin domain-containing protein 1 (Cell surface A33 antigen) (Glycoprotein A34)	VSIG1 GPA34	Homo sapiens (Human)	387			epithelial cell morphogenesis [GO:0003382]; maintenance of gastrointestinal epithelium [GO:0030277]	basolateral plasma membrane [GO:0016323]		basolateral plasma membrane [GO:0016323]; epithelial cell morphogenesis [GO:0003382]; maintenance of gastrointestinal epithelium [GO:0030277]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q86XL3	reviewed	ANKL2_HUMAN	Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4)	ANKLE2 KIAA0692 LEM4	Homo sapiens (Human)	938	FUNCTION: Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}.		cell division [GO:0051301]; central nervous system development [GO:0007417]; mitotic nuclear membrane reassembly [GO:0007084]; negative regulation of apoptotic process [GO:0043066]; negative regulation of phosphorylation [GO:0042326]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of catalytic activity [GO:0050790]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888]; cell division [GO:0051301]; central nervous system development [GO:0007417]; mitotic nuclear membrane reassembly [GO:0007084]; negative regulation of apoptotic process [GO:0043066]; negative regulation of phosphorylation [GO:0042326]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of catalytic activity [GO:0050790]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22770216}; Single-pass type III membrane protein {ECO:0000269|PubMed:22770216}.
Q86XM0	reviewed	CTSRD_HUMAN	Cation channel sperm-associated auxiliary subunit delta (CatSper-delta) (CatSperdelta) (Transmembrane protein 146)	CATSPERD TMEM146	Homo sapiens (Human)	798	FUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane. {ECO:0000250|UniProtKB:E9Q9F6}.		flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]	CatSper complex [GO:0036128]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]		CatSper complex [GO:0036128]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]; flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:E9Q9F6}; Single-pass type I membrane protein {ECO:0000255}. Note=Specifically located in the principal piece of sperm tail. {ECO:0000250|UniProtKB:E9Q9F6}.
Q86XN8	reviewed	MEX3D_HUMAN	RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO)	MEX3D KIAA2031 RKHD1 RNF193	Homo sapiens (Human)	651	FUNCTION: RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. {ECO:0000250}.		mRNA destabilization [GO:0061157]; mRNA localization resulting in post-transcriptional regulation of gene expression [GO:0010609]	nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]	nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; mRNA destabilization [GO:0061157]; mRNA localization resulting in post-transcriptional regulation of gene expression [GO:0010609]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. {ECO:0000250}.
Q86XP0	reviewed	PA24D_HUMAN	Cytosolic phospholipase A2 delta (cPLA2-delta) (EC 3.1.1.4) (Phospholipase A2 group IVD)	PLA2G4D	Homo sapiens (Human)	818	FUNCTION: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). Has a preference for linoleic acid at the sn-2 position (PubMed:14709560). {ECO:0000269|PubMed:14709560}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	fatty acid metabolic process [GO:0006631]; glycerophospholipid catabolic process [GO:0046475]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149]	cytosol [GO:0005829]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; phospholipase A1 activity [GO:0008970]	cytosol [GO:0005829]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; phospholipase A1 activity [GO:0008970]; fatty acid metabolic process [GO:0006631]; glycerophospholipid catabolic process [GO:0046475]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q50L43}. Membrane {ECO:0000250|UniProtKB:Q50L43}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q50L43}; Cytoplasmic side {ECO:0000250|UniProtKB:Q50L43}. Note=Translocates to perinuclear membranes that may correspond to endoplasmic reticulum or Golgi in a calcium-dependent fashion. {ECO:0000250|UniProtKB:Q50L43}.
Q86XP1	reviewed	DGKH_HUMAN	Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta)	DGKH	Homo sapiens (Human)	1220	FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016, ECO:0000269|PubMed:23949095, ECO:0000305}.		diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of catalytic activity [GO:0043086]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidic acid metabolic process [GO:0046473]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; SAM domain binding [GO:0032093]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; SAM domain binding [GO:0032093]; diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of catalytic activity [GO:0043086]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidic acid metabolic process [GO:0046473]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016}. Cell membrane {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016}. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli (PubMed:12810723). Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association (PubMed:12810723). Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS (PubMed:19710016).
Q86XP3	reviewed	DDX42_HUMAN	ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125)	DDX42	Homo sapiens (Human)	938	FUNCTION: ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. {ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511}.		protein localization [GO:0008104]; regulation of apoptotic process [GO:0042981]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; protein localization [GO:0008104]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19377511}. Nucleus {ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, Cajal body {ECO:0000269|PubMed:12234937}. Nucleus speckle {ECO:0000269|PubMed:12234937}.
Q86XQ3	reviewed	CTSR3_HUMAN	Cation channel sperm-associated protein 3 (CatSper3) (Ca(v)-like protein) (One-repeat calcium channel-like protein)	CATSPER3	Homo sapiens (Human)	398	FUNCTION: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.		establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transport [GO:0006814]; sperm capacitation [GO:0048240]	acrosomal vesicle [GO:0001669]; CatSper complex [GO:0036128]; endoplasmic reticulum [GO:0005783]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]	voltage-gated calcium channel activity [GO:0005245]	acrosomal vesicle [GO:0001669]; CatSper complex [GO:0036128]; endoplasmic reticulum [GO:0005783]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; voltage-gated calcium channel activity [GO:0005245]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transport [GO:0006814]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q80W99}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80W99}.
Q86XR7	reviewed	TCAM2_HUMAN	TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4)	TICAM2 TIRAP3 TIRP TRAM	Homo sapiens (Human)	235	FUNCTION: Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606). {ECO:0000269|PubMed:16603631, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:22685567, ECO:0000269|PubMed:25385819, ECO:0000269|PubMed:25825441, ECO:0000269|PubMed:30883606}.; FUNCTION: [Isoform 2]: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.		cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; phagocytosis [GO:0006909]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-18-mediated signaling pathway [GO:2000494]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of type I interferon production [GO:0032481]; response to exogenous dsRNA [GO:0043330]; TRAM-dependent toll-like receptor 4 signaling pathway [GO:0035669]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	cell projection [GO:0042995]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]	cell projection [GO:0042995]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; phagocytosis [GO:0006909]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-18-mediated signaling pathway [GO:2000494]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of type I interferon production [GO:0032481]; response to exogenous dsRNA [GO:0043330]; TRAM-dependent toll-like receptor 4 signaling pathway [GO:0035669]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:25825441}. Golgi apparatus. Cell membrane {ECO:0000269|PubMed:25825441}. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Cell projection, phagocytic cup {ECO:0000269|PubMed:30883606}. Note=Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1.
Q86XR8	reviewed	CEP57_HUMAN	Centrosomal protein of 57 kDa (Cep57) (FGF2-interacting protein) (Testis-specific protein 57) (Translokin)	CEP57 KIAA0092 TSP57	Homo sapiens (Human)	500	FUNCTION: Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1. {ECO:0000269|PubMed:22321063}.		fibroblast growth factor receptor signaling pathway [GO:0008543]; protein homooligomerization [GO:0051260]; spermatid development [GO:0007286]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; nucleus [GO:0005634]	fibroblast growth factor binding [GO:0017134]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; nucleus [GO:0005634]; fibroblast growth factor binding [GO:0017134]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; fibroblast growth factor receptor signaling pathway [GO:0008543]; protein homooligomerization [GO:0051260]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}.
Q86XS8	reviewed	GOLI_HUMAN	E3 ubiquitin-protein ligase RNF130 (EC 2.3.2.27) (Goliath homolog) (H-Goliath) (RING finger protein 130) (RING-type E3 ubiquitin transferase RNF130)	RNF130	Homo sapiens (Human)	419	FUNCTION: May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase. {ECO:0000250, ECO:0000269|PubMed:16549277}.		apoptotic process [GO:0006915]; programmed cell death [GO:0012501]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; membrane [GO:0016020]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; programmed cell death [GO:0012501]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16549277}.
Q86XT2	reviewed	VP37D_HUMAN	Vacuolar protein sorting-associated protein 37D (ESCRT-I complex subunit VPS37D) (Williams-Beuren syndrome chromosomal region 24 protein)	VPS37D WBSCR24	Homo sapiens (Human)	251	FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.		macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]	endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]		endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Q86XT4	reviewed	TRI50_HUMAN	E3 ubiquitin-protein ligase TRIM50 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM50) (Tripartite motif-containing protein 50)	TRIM50 TRIM50A	Homo sapiens (Human)	487	FUNCTION: E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 (PubMed:29604308). In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction (PubMed:22792322). Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity). {ECO:0000250|UniProtKB:Q810I2, ECO:0000269|PubMed:18398435, ECO:0000269|PubMed:22792322, ECO:0000269|PubMed:29604308}.		protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22792322, ECO:0000269|PubMed:24308962, ECO:0000269|PubMed:29604308}. Note=Localizes mainly into discrete cytoplasmic punctuate structures heterogeneous in size and shape containing polyubiquitinated proteins. {ECO:0000269|PubMed:22792322}.
Q86XX4	reviewed	FRAS1_HUMAN	Extracellular matrix organizing protein FRAS1 (Fraser syndrome 1 protein)	FRAS1 KIAA1500	Homo sapiens (Human)	4008	FUNCTION: Involved in extracellular matrix organization (By similarity). Required for the regulation of epidermal-basement membrane adhesion responsible for proper organogenesis during embryonic development (By similarity). Involved in brain organization and function (By similarity). {ECO:0000250|UniProtKB:Q80T14}.		anatomical structure morphogenesis [GO:0009653]; cell communication [GO:0007154]; embryonic limb morphogenesis [GO:0030326]; metanephros morphogenesis [GO:0003338]; morphogenesis of an epithelium [GO:0002009]; protein transport [GO:0015031]; roof of mouth development [GO:0060021]; skin development [GO:0043588]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; plasma membrane [GO:0005886]	extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; plasma membrane [GO:0005886]; extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872]; anatomical structure morphogenesis [GO:0009653]; cell communication [GO:0007154]; embryonic limb morphogenesis [GO:0030326]; metanephros morphogenesis [GO:0003338]; morphogenesis of an epithelium [GO:0002009]; protein transport [GO:0015031]; roof of mouth development [GO:0060021]; skin development [GO:0043588]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80T14}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q80T14}; Extracellular side {ECO:0000250|UniProtKB:Q80T14}.
Q86Y01	reviewed	DTX1_HUMAN	E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1)	DTX1	Homo sapiens (Human)	620	FUNCTION: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}.		cell surface receptor signaling pathway [GO:0007166]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA-templated transcription [GO:0006351]; glial cell differentiation [GO:0010001]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of T cell differentiation [GO:0045581]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	Notch binding [GO:0005112]; SH3 domain binding [GO:0017124]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; Notch binding [GO:0005112]; SH3 domain binding [GO:0017124]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; cell surface receptor signaling pathway [GO:0007166]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA-templated transcription [GO:0006351]; glial cell differentiation [GO:0010001]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of T cell differentiation [GO:0045581]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
Q86Y07	reviewed	VRK2_HUMAN	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)	VRK2	Homo sapiens (Human)	508	FUNCTION: Serine/threonine kinase that regulates several signal transduction pathways (PubMed:16704422, PubMed:14645249, PubMed:16495336, PubMed:17709393, PubMed:18617507, PubMed:18286207, PubMed:20679487). Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes (PubMed:17709393). Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription (PubMed:18286207). Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1 (PubMed:16704422). Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins (PubMed:16495336). Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 (PubMed:20679487). Blocks the phosphorylation of ERK in response to ERBB2 and HRAS (PubMed:20679487). Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (PubMed:14645249). {ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:17709393, ECO:0000269|PubMed:18286207, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:20679487}.; FUNCTION: [Isoform 2]: Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity. {ECO:0000269|PubMed:16704422}.		cellular response to oxidative stress [GO:0034599]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of interleukin-1-mediated signaling pathway [GO:2000659]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cellular response to oxidative stress [GO:0034599]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of interleukin-1-mediated signaling pathway [GO:2000659]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16704422}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16704422}; Single-pass type IV membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:16704422}; Single-pass type IV membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q8BN21}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16704422}. Nucleus {ECO:0000269|PubMed:16704422}.
Q86Y13	reviewed	DZIP3_HUMAN	E3 ubiquitin-protein ligase DZIP3 (EC 2.3.2.27) (DAZ-interacting protein 3) (RING-type E3 ubiquitin transferase DZIP3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138)	DZIP3 KIAA0675	Homo sapiens (Human)	1208	FUNCTION: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. {ECO:0000269|PubMed:12538761}.		protein polyubiquitination [GO:0000209]	cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; protein polyubiquitination [GO:0000209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12538761}.
Q86Y26	reviewed	NUTM1_HUMAN	NUT family member 1 (Nuclear protein in testis)	NUTM1 C15orf55 NUT	Homo sapiens (Human)	1132	FUNCTION: Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. {ECO:0000269|PubMed:30447097}.			cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17934517}. Nucleus {ECO:0000269|PubMed:17934517}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000269|PubMed:17934517}.
Q86Y33	reviewed	CD20B_HUMAN	Cell division cycle protein 20 homolog B	CDC20B G6VTS76519	Homo sapiens (Human)	519	FUNCTION: Protein regulator of centriole-deuterosome disengagement and subsequently participates in the ciliogenesis in multiciliated cells (MCCs). {ECO:0000250|UniProtKB:A0A1L8I2C5}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; de novo centriole assembly [GO:0097742]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]	anaphase-promoting complex [GO:0005680]; cytoplasm [GO:0005737]; deuterosome [GO:0098536]	anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757]	anaphase-promoting complex [GO:0005680]; cytoplasm [GO:0005737]; deuterosome [GO:0098536]; anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; de novo centriole assembly [GO:0097742]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]	SUBCELLULAR LOCATION: Cytoplasm. Note=Tightly associated to mature deuterosomes. {ECO:0000269|PubMed:30405130}.
Q86Y34	reviewed	AGRG3_HUMAN	Adhesion G protein-coupled receptor G3 (G-protein coupled receptor 97) (G-protein coupled receptor PGR26)	ADGRG3 GPR97 PGR26	Homo sapiens (Human)	549	FUNCTION: Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658). {ECO:0000250|UniProtKB:Q8R0T6, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:24178298}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; B cell differentiation [GO:0030183]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; regulation of cell migration [GO:0030334]	membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; B cell differentiation [GO:0030183]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; regulation of cell migration [GO:0030334]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22575658}; Multi-pass membrane protein {ECO:0000255}.
Q86Y37	reviewed	CACL1_HUMAN	CDK2-associated and cullin domain-containing protein 1 (Cdk-associated cullin 1)	CACUL1 C10orf46 CAC1	Homo sapiens (Human)	369	FUNCTION: Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. {ECO:0000269|PubMed:19829063}.		G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein kinase activity [GO:0045860]; ubiquitin-dependent protein catabolic process [GO:0006511]		protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625]	protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein kinase activity [GO:0045860]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q86Y38	reviewed	XYLT1_HUMAN	Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)	XYLT1 XT1	Homo sapiens (Human)	959	FUNCTION: Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (PubMed:15461586, PubMed:17189265, PubMed:24581741, PubMed:23982343). Required for normal embryonic and postnatal skeleton development, especially of the long bones (PubMed:24581741, PubMed:23982343). Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity). {ECO:0000250|UniProtKB:Q811B1, ECO:0000269|PubMed:15461586, ECO:0000269|PubMed:17189265, ECO:0000269|PubMed:23982343, ECO:0000269|PubMed:24581741}.	MISCELLANEOUS: Activity is strongly reduced in seminal plasma of infertile men. {ECO:0000269|PubMed:11814476}.	chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; embryonic skeletal system development [GO:0048706]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; ossification involved in bone maturation [GO:0043931]; proteoglycan biosynthetic process [GO:0030166]	extracellular space [GO:0005615]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]	metal ion binding [GO:0046872]; protein xylosyltransferase activity [GO:0030158]	extracellular space [GO:0005615]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; metal ion binding [GO:0046872]; protein xylosyltransferase activity [GO:0030158]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; embryonic skeletal system development [GO:0048706]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; ossification involved in bone maturation [GO:0043931]; proteoglycan biosynthetic process [GO:0030166]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23982343, ECO:0000269|PubMed:28462984}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:11087729, ECO:0000269|PubMed:16571645}. Note=Detected predominantly in the Golgi apparatus. {ECO:0000269|PubMed:28462984}.
Q86Y39	reviewed	NDUAB_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (Complex I-B14.7) (CI-B14.7) (NADH-ubiquinone oxidoreductase subunit B14.7)	NDUFA11	Homo sapiens (Human)	141	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; aerobic respiration [GO:0009060]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Multi-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
Q86Y46	reviewed	K2C73_HUMAN	Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36)	KRT73 K6IRS3 KB36 KRT6IRS3	Homo sapiens (Human)	540	FUNCTION: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; nucleus [GO:0005634]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; nucleus [GO:0005634]; structural constituent of skin epidermis [GO:0030280]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
Q86Y56	reviewed	DAAF5_HUMAN	Dynein axonemal assembly factor 5 (HEAT repeat-containing protein 2)	DNAAF5 HEATR2	Homo sapiens (Human)	855	FUNCTION: Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. {ECO:0000269|PubMed:23040496, ECO:0000269|PubMed:25232951}.		cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158]	cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293]; dynein intermediate chain binding [GO:0045505]; cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23040496, ECO:0000269|PubMed:25232951}. Dynein axonemal particle {ECO:0000269|PubMed:23040496, ECO:0000269|PubMed:25232951}. Note=Observed only in the cytoplasm of ciliated cells and absent from cilia. {ECO:0000269|PubMed:23040496, ECO:0000269|PubMed:25232951}.
Q86Y78	reviewed	LYPD6_HUMAN	Ly6/PLAUR domain-containing protein 6	LYPD6 UNQ3023/PRO9821	Homo sapiens (Human)	171	FUNCTION: Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (PubMed:27344019, PubMed:34631692). Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (PubMed:34631692). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). {ECO:0000250|UniProtKB:Q66IA6, ECO:0000269|PubMed:27344019, ECO:0000269|PubMed:34631692}.		positive regulation of canonical Wnt signaling pathway [GO:0090263]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]	acetylcholine receptor inhibitor activity [GO:0030550]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]; acetylcholine receptor inhibitor activity [GO:0030550]; positive regulation of canonical Wnt signaling pathway [GO:0090263]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:19653121}. Cell membrane {ECO:0000269|PubMed:25680266}; Lipid-anchor, GPI-anchor {ECO:0000255}. Synapse, synaptosome {ECO:0000250|UniProtKB:D3ZTT2}. Membrane raft {ECO:0000250|UniProtKB:Q66IA6}. Cell projection, dendrite {ECO:0000250|UniProtKB:D3ZTT2}. Perikaryon {ECO:0000250|UniProtKB:D3ZTT2}. Note=Colocalizes with alpha-3:beta-4- and alpha-7- nicotinic acetylcholine receptors (nAChRs) in the primary cortex and hippocampus. {ECO:0000250|UniProtKB:D3ZTT2}.
Q86Y82	reviewed	STX12_HUMAN	Syntaxin-12	STX12	Homo sapiens (Human)	276	FUNCTION: SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. {ECO:0000250|UniProtKB:G3V7P1}.		autophagosome assembly [GO:0000045]; cholesterol efflux [GO:0033344]; endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; protein stabilization [GO:0050821]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; phagophore assembly site [GO:0000407]; postsynaptic recycling endosome [GO:0098837]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; phagophore assembly site [GO:0000407]; postsynaptic recycling endosome [GO:0098837]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; autophagosome assembly [GO:0000045]; cholesterol efflux [GO:0033344]; endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; protein stabilization [GO:0050821]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:G3V7P1}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1}. Golgi apparatus membrane {ECO:0000250|UniProtKB:G3V7P1}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1}. Endomembrane system {ECO:0000250|UniProtKB:G3V7P1}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1}; Cytoplasmic side {ECO:0000250|UniProtKB:G3V7P1}. Early endosome membrane {ECO:0000250|UniProtKB:G3V7P1}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1}. Recycling endosome membrane {ECO:0000250|UniProtKB:G3V7P1}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1}.
Q86Y91	reviewed	KI18B_HUMAN	Kinesin-like protein KIF18B	KIF18B	Homo sapiens (Human)	852	FUNCTION: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. {ECO:0000269|PubMed:20600703, ECO:0000269|PubMed:21820309}.		cell division [GO:0051301]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; regulation of cell division [GO:0051302]	astral microtubule [GO:0000235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; microtubule end [GO:1990752]; microtubule plus-end [GO:0035371]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle midzone [GO:1990023]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]	astral microtubule [GO:0000235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; microtubule end [GO:1990752]; microtubule plus-end [GO:0035371]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle midzone [GO:1990023]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]; cell division [GO:0051301]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; regulation of cell division [GO:0051302]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase.
Q86Y97	reviewed	KMT5C_HUMAN	Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361)	KMT5C SUV420H2 PP7130	Homo sapiens (Human)	462	FUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q6Q783, ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	DNA repair [GO:0006281]; methylation [GO:0032259]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]	condensed chromosome, centromeric region [GO:0000779]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H4 methyltransferase activity [GO:0140939]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]	condensed chromosome, centromeric region [GO:0000779]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H4 methyltransferase activity [GO:0140939]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]; DNA repair [GO:0006281]; methylation [GO:0032259]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]	SUBCELLULAR LOCATION: Nucleus. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.
Q86YA3	reviewed	ZGRF1_HUMAN	Protein ZGRF1 (GRF-type zinc finger domain-containing protein 1)	ZGRF1 C4orf21	Homo sapiens (Human)	2104			double-strand break repair [GO:0006302]	membrane [GO:0016020]; site of double-strand break [GO:0035861]	helicase activity [GO:0004386]; zinc ion binding [GO:0008270]	membrane [GO:0016020]; site of double-strand break [GO:0035861]; helicase activity [GO:0004386]; zinc ion binding [GO:0008270]; double-strand break repair [GO:0006302]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q86YB8	reviewed	ERO1B_HUMAN	ERO1-like protein beta (ERO1-L-beta) (EC 1.8.4.-) (Endoplasmic reticulum oxidoreductase beta) (Endoplasmic reticulum oxidoreductin-1-like protein B) (Oxidoreductin-1-L-beta)	ERO1B ERO1LB	Homo sapiens (Human)	467	FUNCTION: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis. {ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:21091435}.		insulin processing [GO:0030070]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]	FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972]; unfolded protein binding [GO:0051082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972]; unfolded protein binding [GO:0051082]; insulin processing [GO:0030070]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10818100}; Peripheral membrane protein {ECO:0000269|PubMed:10818100}; Lumenal side {ECO:0000269|PubMed:10818100}. Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum.
Q86YC2	reviewed	PALB2_HUMAN	Partner and localizer of BRCA2	PALB2 FANCN	Homo sapiens (Human)	1186	FUNCTION: Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19423707, PubMed:19369211, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}.		animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; double-strand break repair via homologous recombination [GO:0000724]; embryonic organ development [GO:0048568]; inner cell mass cell proliferation [GO:0001833]; mesoderm development [GO:0007498]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; post-anal tail morphogenesis [GO:0036342]; somitogenesis [GO:0001756]	DNA repair complex [GO:1990391]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA binding [GO:0003677]	DNA repair complex [GO:1990391]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; double-strand break repair via homologous recombination [GO:0000724]; embryonic organ development [GO:0048568]; inner cell mass cell proliferation [GO:0001833]; mesoderm development [GO:0007498]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; post-anal tail morphogenesis [GO:0036342]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:28319063}. Note=Colocalizes with BRCA2 and BRCA1 in nuclear foci. {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:28319063}.
Q86YC3	reviewed	LRC33_HUMAN	Transforming growth factor beta activator LRRC33 (Leucine-rich repeat-containing protein 33) (Negative regulator of reactive oxygen species)	NRROS LRRC33 UNQ3030/PRO9833	Homo sapiens (Human)	692	FUNCTION: Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 (By similarity). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (By similarity). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (PubMed:23545260). {ECO:0000250|UniProtKB:Q8BMT4, ECO:0000269|PubMed:23545260}.		immune response [GO:0006955]; inflammatory response [GO:0006954]; microglia development [GO:0014005]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; transforming growth factor beta receptor signaling pathway [GO:0007179]; transforming growth factor beta1 activation [GO:0036364]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	transforming growth factor beta binding [GO:0050431]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; transforming growth factor beta binding [GO:0050431]; immune response [GO:0006955]; inflammatory response [GO:0006954]; microglia development [GO:0014005]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; transforming growth factor beta receptor signaling pathway [GO:0007179]; transforming growth factor beta1 activation [GO:0036364]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23545260, ECO:0000269|PubMed:29909984}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:32197075}; Single-pass type I membrane protein {ECO:0000255}.
Q86YD1	reviewed	PTOV1_HUMAN	Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2)	PTOV1 ACID2 PP642 UNQ6127/PRO20092	Homo sapiens (Human)	416	FUNCTION: May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644, ECO:0000269|PubMed:17641689}.		positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]		nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:16639697}. Nucleus {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644}. Cell membrane {ECO:0000269|PubMed:15713644}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11313889}. Note=Translocates from the cytoplasm to the nucleus at the onset of S-phase (PubMed:12598323). Also localizes to lipid rafts (PubMed:15713644). {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644}.
Q86YD3	reviewed	TMM25_HUMAN	Transmembrane protein 25	TMEM25 UNQ2531/PRO6030	Homo sapiens (Human)	366	FUNCTION: In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. {ECO:0000269|PubMed:31424425}.		negative regulation of excitatory postsynaptic potential [GO:0090394]; regulation of protein stability [GO:0031647]	extracellular region [GO:0005576]; late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; negative regulation of excitatory postsynaptic potential [GO:0090394]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: Late endosome {ECO:0000250|UniProtKB:Q9DCF1}. Lysosome {ECO:0000250|UniProtKB:Q9DCF1}.
Q86YD5	reviewed	LRAD3_HUMAN	Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR class A domain-containing protein 3)	LDLRAD3 LRAD3	Homo sapiens (Human)	345	FUNCTION: May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353). {ECO:0000250, ECO:0000269|PubMed:26854353}.; FUNCTION: (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:33208938, ECO:0000269|PubMed:34646020, ECO:0000269|PubMed:34646021}.		receptor-mediated endocytosis [GO:0006898]; regulation of protein processing [GO:0070613]	plasma membrane [GO:0005886]	amyloid-beta binding [GO:0001540]	plasma membrane [GO:0005886]; amyloid-beta binding [GO:0001540]; receptor-mediated endocytosis [GO:0006898]; regulation of protein processing [GO:0070613]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33208938, ECO:0000269|PubMed:34646020, ECO:0000269|PubMed:34646021}; Single-pass type I membrane protein {ECO:0000250}.
Q86YD7	reviewed	F90A1_HUMAN	Protein FAM90A1	FAM90A1	Homo sapiens (Human)	464							
Q86YF9	reviewed	DZIP1_HUMAN	Cilium assembly protein DZIP1 (DAZ-interacting protein 1/2) (DAZ-interacting zinc finger protein 1)	DZIP1 DZIP DZIP2 KIAA0996	Homo sapiens (Human)	867	FUNCTION: Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body (PubMed:19852954, PubMed:23955340, PubMed:27979967, PubMed:32051257). At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium (By similarity). Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium (PubMed:27979967). It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN (By similarity). Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm (By similarity). It is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum (PubMed:32051257). Also indirectly involved in heart development through its function in ciliogenesis (PubMed:31118289). {ECO:0000250|UniProtKB:Q8BMD2, ECO:0000269|PubMed:19852954, ECO:0000269|PubMed:23955340, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:31118289, ECO:0000269|PubMed:32051257}.		ciliary basal body organization [GO:0032053]; cilium assembly [GO:0060271]; cytoplasmic sequestering of protein [GO:0051220]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; germ cell development [GO:0007281]; heart development [GO:0007507]; maintenance of protein location in cell [GO:0032507]; positive regulation of cilium assembly [GO:0045724]; positive regulation of protein localization to cilium [GO:1903566]; protein localization to cilium [GO:0061512]; protein-containing complex localization to centriolar satellite [GO:0140706]; smoothened signaling pathway [GO:0007224]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition fiber [GO:0097539]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	BBSome binding [GO:0062063]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition fiber [GO:0097539]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; BBSome binding [GO:0062063]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; ciliary basal body organization [GO:0032053]; cilium assembly [GO:0060271]; cytoplasmic sequestering of protein [GO:0051220]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; germ cell development [GO:0007281]; heart development [GO:0007507]; maintenance of protein location in cell [GO:0032507]; positive regulation of cilium assembly [GO:0045724]; positive regulation of protein localization to cilium [GO:1903566]; protein localization to cilium [GO:0061512]; protein-containing complex localization to centriolar satellite [GO:0140706]; smoothened signaling pathway [GO:0007224]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19852954}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:27979967}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:19852954}. Nucleus {ECO:0000269|PubMed:15081113}. Nucleus speckle {ECO:0000250|UniProtKB:Q8BMD2}. Cytoplasm {ECO:0000269|PubMed:15081113}. Note=Localizes to the centriole in cells lacking cilia and to the cilium basal body in ciliated cells (PubMed:19852954). At the exit of mitosis, when the primary cilium is reassembled in daughter cells, localizes at the mother centriole that acts as the basal body of the assembling primary cilium and also accumulates at the ciliary base that constitutes a diffusion barrier for ciliary proteins (By similarity). {ECO:0000250|UniProtKB:Q8BMD2, ECO:0000269|PubMed:19852954}.
Q86YH6	reviewed	DLP1_HUMAN	All trans-polyprenyl-diphosphate synthase PDSS2 (All-trans-decaprenyl-diphosphate synthase subunit 2) (EC 2.5.1.91) (Candidate tumor suppressor protein) (Decaprenyl pyrophosphate synthase subunit 2) (Decaprenyl-diphosphate synthase subunit 2) (Solanesyl-diphosphate synthase subunit 2)	PDSS2 C6orf210 DLP1	Homo sapiens (Human)	399	FUNCTION: Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone (PubMed:16262699). Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9) and ubiquinone-10 (Q10) respectively (PubMed:16262699). The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (PubMed:16262699). May play a role during cerebellar development (By similarity). May regulate mitochondrial respiratory chain function (By similarity). {ECO:0000250|UniProtKB:Q33DR3, ECO:0000269|PubMed:16262699}.		cerebellum development [GO:0021549]; isoprenoid biosynthetic process [GO:0008299]; regulation of body fluid levels [GO:0050878]; ubiquinone biosynthetic process [GO:0006744]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; transferase complex [GO:1990234]	all-trans-decaprenyl-diphosphate synthase activity [GO:0097269]; all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity [GO:0052923]; prenyltransferase activity [GO:0004659]; protein heterodimerization activity [GO:0046982]; trans-hexaprenyltranstransferase activity [GO:0000010]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; transferase complex [GO:1990234]; all-trans-decaprenyl-diphosphate synthase activity [GO:0097269]; all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity [GO:0052923]; prenyltransferase activity [GO:0004659]; protein heterodimerization activity [GO:0046982]; trans-hexaprenyltranstransferase activity [GO:0000010]; cerebellum development [GO:0021549]; isoprenoid biosynthetic process [GO:0008299]; regulation of body fluid levels [GO:0050878]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q86YI8	reviewed	PHF13_HUMAN	PHD finger protein 13 (Survival time-associated PHD finger protein in ovarian cancer 1) (SPOC1)	PHF13	Homo sapiens (Human)	300	FUNCTION: Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. {ECO:0000269|PubMed:19638409}.		cell division [GO:0051301]; chromatin organization [GO:0006325]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; cell division [GO:0051301]; chromatin organization [GO:0006325]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19638409}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19638409}. Note=Predominantly bound to chromatin, but a minor proportion is also detected in the nucleoplasm.
Q86YJ5	reviewed	MARH9_HUMAN	E3 ubiquitin-protein ligase MARCHF9 (EC 2.3.2.27) (Membrane-associated RING finger protein 9) (Membrane-associated RING-CH protein IX) (MARCH-IX) (RING finger protein 179) (RING-type E3 ubiquitin transferase MARCHF9)	MARCHF9 MARCH9 RNF179	Homo sapiens (Human)	346	FUNCTION: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:17174307}.	MISCELLANEOUS: [Isoform 2]: Has no E3 activity due to lack of RINGv-type zinc finger domain but is able to dimerize with and stabilize isoform 1. {ECO:0000305}.	protein ubiquitination [GO:0016567]	Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; lysosomal membrane [GO:0005765]; trans-Golgi network [GO:0005802]	ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; lysosomal membrane [GO:0005765]; trans-Golgi network [GO:0005802]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17174307}; Multi-pass membrane protein {ECO:0000255}.
Q86YJ6	reviewed	THNS2_HUMAN	Threonine synthase-like 2 (TSH2) (EC 4.2.3.-) (Secreted osteoclastogenic factor of activated T-cells) (SOFAT)	THNSL2	Homo sapiens (Human)	484	FUNCTION: [Isoform 1]: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity). {ECO:0000250}.; FUNCTION: [Isoform SOFAT]: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions. {ECO:0000269|PubMed:19877052}.		2-oxobutyrate biosynthetic process [GO:0046360]; dephosphorylation [GO:0016311]; serine family amino acid catabolic process [GO:0009071]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]; lyase activity [GO:0016829]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; lyase activity [GO:0016829]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]; 2-oxobutyrate biosynthetic process [GO:0046360]; dephosphorylation [GO:0016311]; serine family amino acid catabolic process [GO:0009071]	SUBCELLULAR LOCATION: [Isoform SOFAT]: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway.
Q86YJ7	reviewed	AN13B_HUMAN	Ankyrin repeat domain-containing protein 13B	ANKRD13B	Homo sapiens (Human)	626	FUNCTION: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269|PubMed:22298428}.		negative regulation of receptor internalization [GO:0002091]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	ubiquitin-dependent protein binding [GO:0140036]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ubiquitin-dependent protein binding [GO:0140036]; negative regulation of receptor internalization [GO:0002091]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22298428}. Late endosome {ECO:0000269|PubMed:22298428}. Early endosome {ECO:0000269|PubMed:22298428}. Note=Interaction with EGFR may enhance association with the cell membrane.
Q86YL7	reviewed	PDPN_HUMAN	Podoplanin (Aggrus) (Glycoprotein 36) (Gp36) (PA2.26 antigen) (T1-alpha) (T1A) [Cleaved into: 29kDa cytosolic podoplanin intracellular domain (PICD)]	PDPN GP36 PSEC0003 PSEC0025	Homo sapiens (Human)	162	FUNCTION: Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed:14522983, PubMed:15231832, PubMed:17616532, PubMed:18215137, PubMed:17222411). Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN (PubMed:18541721). Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness (PubMed:17046996, PubMed:21376833). Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (PubMed:20962267). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (By similarity). Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix (PubMed:19268462). In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion (PubMed:15515019). Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 (PubMed:25486435). Required for normal lung cell proliferation and alveolus formation at birth (By similarity). Does not function as a water channel or as a regulator of aquaporin-type water channels (PubMed:9651190). Does not have any effect on folic acid or amino acid transport (By similarity). {ECO:0000250|UniProtKB:Q62011, ECO:0000269|PubMed:14522983, ECO:0000269|PubMed:15231832, ECO:0000269|PubMed:15515019, ECO:0000269|PubMed:17046996, ECO:0000269|PubMed:17222411, ECO:0000269|PubMed:17616532, ECO:0000269|PubMed:18215137, ECO:0000269|PubMed:18541721, ECO:0000269|PubMed:19268462, ECO:0000269|PubMed:20962267, ECO:0000269|PubMed:21376833, ECO:0000269|PubMed:25486435, ECO:0000269|PubMed:9651190}.		actin-mediated cell contraction [GO:0070252]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; lung development [GO:0030324]; lymph node development [GO:0048535]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell fate commitment [GO:0060838]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; platelet activation [GO:0030168]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of platelet aggregation [GO:1901731]; regulation of cell shape [GO:0008360]; regulation of lamellipodium morphogenesis [GO:2000392]; regulation of myofibroblast contraction [GO:1904328]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; response to hyperoxia [GO:0055093]; Rho protein signal transduction [GO:0007266]; wound healing, spreading of cells [GO:0044319]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; leading edge of lamellipodium [GO:0061851]; membrane [GO:0016020]; membrane raft [GO:0045121]; microvillus membrane [GO:0031528]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; tetraspanin-enriched microdomain [GO:0097197]	chemokine binding [GO:0019956]; protein-folding chaperone binding [GO:0051087]; signaling receptor binding [GO:0005102]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; leading edge of lamellipodium [GO:0061851]; membrane [GO:0016020]; membrane raft [GO:0045121]; microvillus membrane [GO:0031528]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; tetraspanin-enriched microdomain [GO:0097197]; chemokine binding [GO:0019956]; protein-folding chaperone binding [GO:0051087]; signaling receptor binding [GO:0005102]; actin-mediated cell contraction [GO:0070252]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; lung development [GO:0030324]; lymph node development [GO:0048535]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell fate commitment [GO:0060838]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; platelet activation [GO:0030168]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of platelet aggregation [GO:1901731]; regulation of cell shape [GO:0008360]; regulation of lamellipodium morphogenesis [GO:2000392]; regulation of myofibroblast contraction [GO:1904328]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; response to hyperoxia [GO:0055093]; Rho protein signal transduction [GO:0007266]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: [Podoplanin]: Membrane {ECO:0000269|PubMed:17046996, ECO:0000269|PubMed:20962267, ECO:0000305|PubMed:18215137}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62011}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:17046996, ECO:0000269|PubMed:20962267}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62011}. Cell projection, filopodium membrane {ECO:0000269|PubMed:17046996}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62011}. Cell projection, microvillus membrane {ECO:0000269|PubMed:17046996}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62011}. Cell projection, ruffle membrane {ECO:0000269|PubMed:17046996}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62011}. Membrane raft {ECO:0000269|PubMed:21376833}. Apical cell membrane {ECO:0000269|PubMed:20962267}. Basolateral cell membrane {ECO:0000269|PubMed:14978162}. Cell projection, invadopodium {ECO:0000269|PubMed:25486435}. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles (By similarity). Association to the lipid rafts is required for PDPN-induced epithelial to mesenchymal transition (EMT) (PubMed:21376833). Colocalizes with CD9 in tetraspanin microdomains (PubMed:18541721). Localized at invadopodium adhesion rings in tumor cell. Association to the lipid rafts is essential for PDPN recruitment to invadopodia and ECM degradation (PubMed:25486435). {ECO:0000250|UniProtKB:Q62011, ECO:0000269|PubMed:18541721, ECO:0000269|PubMed:21376833, ECO:0000269|PubMed:25486435}.; SUBCELLULAR LOCATION: [29kDa cytosolic podoplanin intracellular domain]: Cytoplasm, cytosol {ECO:0000269|PubMed:24275092}.
Q86YM7	reviewed	HOME1_HUMAN	Homer protein homolog 1 (Homer-1)	HOMER1 SYN47	Homo sapiens (Human)	354	FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000250|UniProtKB:Q9Z214, ECO:0000269|PubMed:18218901}.		behavioral response to cocaine [GO:0048148]; chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of signal transduction [GO:0009967]; protein localization to synapse [GO:0035418]; protein tetramerization [GO:0051262]; regulation of calcium ion import [GO:0090279]; regulation of cation channel activity [GO:2001257]; regulation of dendritic spine maintenance [GO:1902950]; regulation of store-operated calcium entry [GO:2001256]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to calcium ion [GO:0051592]; response to nicotine [GO:0035094]; skeletal muscle contraction [GO:0003009]; skeletal muscle fiber development [GO:0048741]	apical part of cell [GO:0045177]; axon [GO:0030424]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; Z disc [GO:0030018]	G protein-coupled glutamate receptor binding [GO:0035256]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; signaling adaptor activity [GO:0035591]; structural constituent of postsynapse [GO:0099186]; transmembrane transporter binding [GO:0044325]; type 5 metabotropic glutamate receptor binding [GO:0031802]	apical part of cell [GO:0045177]; axon [GO:0030424]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; Z disc [GO:0030018]; G protein-coupled glutamate receptor binding [GO:0035256]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; signaling adaptor activity [GO:0035591]; structural constituent of postsynapse [GO:0099186]; transmembrane transporter binding [GO:0044325]; type 5 metabotropic glutamate receptor binding [GO:0031802]; behavioral response to cocaine [GO:0048148]; chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of signal transduction [GO:0009967]; protein localization to synapse [GO:0035418]; protein tetramerization [GO:0051262]; regulation of calcium ion import [GO:0090279]; regulation of cation channel activity [GO:2001257]; regulation of dendritic spine maintenance [GO:1902950]; regulation of store-operated calcium entry [GO:2001256]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to calcium ion [GO:0051592]; response to nicotine [GO:0035094]; skeletal muscle contraction [GO:0003009]; skeletal muscle fiber development [GO:0048741]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z214}. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. {ECO:0000250}.
Q86YN6	reviewed	PRGC2_HUMAN	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator)	PPARGC1B PERC PGC1 PGC1B PPARGC1	Homo sapiens (Human)	1023	FUNCTION: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}.	MISCELLANEOUS: [Isoform 5]: Lacks LXXLL motif 1 and has a reduced ability to enhance the hormone-dependent activity of estrogen receptor alpha. {ECO:0000305}.	actin filament organization [GO:0007015]; bone trabecula formation [GO:0060346]; cellular response to reactive oxygen species [GO:0034614]; intracellular estrogen receptor signaling pathway [GO:0030520]; mitochondrial transcription [GO:0006390]; negative regulation of DNA-templated transcription [GO:0045892]; ossification [GO:0001503]; positive regulation of bone resorption [GO:0045780]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; mediator complex [GO:0016592]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	AF-2 domain binding [GO:0050682]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712]	cytosol [GO:0005829]; mediator complex [GO:0016592]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; AF-2 domain binding [GO:0050682]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712]; actin filament organization [GO:0007015]; bone trabecula formation [GO:0060346]; cellular response to reactive oxygen species [GO:0034614]; intracellular estrogen receptor signaling pathway [GO:0030520]; mitochondrial transcription [GO:0006390]; negative regulation of DNA-templated transcription [GO:0045892]; ossification [GO:0001503]; positive regulation of bone resorption [GO:0045780]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11854298}.
Q86YP4	reviewed	P66A_HUMAN	Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A)	GATAD2A	Homo sapiens (Human)	633	FUNCTION: Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.		chromatin remodeling [GO:0006338]; DNA methylation [GO:0006306]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]	metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; sequence-specific DNA binding [GO:0043565]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; sequence-specific DNA binding [GO:0043565]; chromatin remodeling [GO:0006338]; DNA methylation [GO:0006306]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}. Nucleus {ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Chromosome {ECO:0000269|PubMed:27732854}. Note=Speckled nuclear localization requires both CR1 and CR2 regions (PubMed:16415179). Localizes to sites of DNA damage in a manner partially dependent on ZMYND8 (PubMed:27732854). {ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:27732854}.
Q86YR5	reviewed	GPSM1_HUMAN	G-protein-signaling modulator 1 (Activator of G-protein signaling 3)	GPSM1 AGS3	Homo sapiens (Human)	675	FUNCTION: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}.	MISCELLANEOUS: [Isoform 2]: Minor isoform. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Major isoform. {ECO:0000305}.	cell differentiation [GO:0030154]; establishment of mitotic spindle orientation [GO:0000132]; negative regulation of GTPase activity [GO:0034260]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; nervous system development [GO:0007399]; positive regulation of macroautophagy [GO:0016239]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	G-protein alpha-subunit binding [GO:0001965]; GDP-dissociation inhibitor activity [GO:0005092]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; G-protein alpha-subunit binding [GO:0001965]; GDP-dissociation inhibitor activity [GO:0005092]; cell differentiation [GO:0030154]; establishment of mitotic spindle orientation [GO:0000132]; negative regulation of GTPase activity [GO:0034260]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; nervous system development [GO:0007399]; positive regulation of macroautophagy [GO:0016239]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Q86YR7	reviewed	MF2L2_HUMAN	Probable guanine nucleotide exchange factor MCF2L2 (Dbs-related Rho family guanine nucleotide exchange factor) (MCF2-transforming sequence-like protein 2)	MCF2L2 ARHGEF22 DRG KIAA0861	Homo sapiens (Human)	1114	FUNCTION: Probably functions as a guanine nucleotide exchange factor. {ECO:0000250}.		regulation of response to stimulus [GO:0048583]	cytoplasm [GO:0005737]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of response to stimulus [GO:0048583]	
Q86YS3	reviewed	RFIP4_HUMAN	Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2)	RAB11FIP4 ARFO2 KIAA1821	Homo sapiens (Human)	637	FUNCTION: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. {ECO:0000269|PubMed:12470645}.		endocytic recycling [GO:0032456]; regulation of cytokinesis [GO:0032465]	cleavage furrow [GO:0032154]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular space [GO:0005615]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; recycling endosome membrane [GO:0055038]; spindle [GO:0005819]	calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]	cleavage furrow [GO:0032154]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular space [GO:0005615]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; recycling endosome membrane [GO:0055038]; spindle [GO:0005819]; calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; endocytic recycling [GO:0032456]; regulation of cytokinesis [GO:0032465]	SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:20682791}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:12857874}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12857874}. Recycling endosome membrane {ECO:0000269|PubMed:15601896}; Peripheral membrane protein. Cleavage furrow {ECO:0000269|PubMed:15601896}. Midbody {ECO:0000269|PubMed:12857874, ECO:0000269|PubMed:15601896}. Cytoplasmic vesicle {ECO:0000269|PubMed:15601896}. Note=Recruited to the cleavage furrow and the midbody during cytokinesis. {ECO:0000269|PubMed:15601896}.
Q86YS6	reviewed	RAB43_HUMAN	Ras-related protein Rab-43 (Ras-related protein Rab-41)	RAB43 RAB41	Homo sapiens (Human)	212	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057, ECO:0000269|PubMed:18664496, ECO:0000269|PubMed:21255211}.		autophagosome assembly [GO:0000045]; cellular response to type II interferon [GO:0071346]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; phagosome maturation [GO:0090382]; retrograde transport, plasma membrane to Golgi [GO:0035526]; virion assembly [GO:0019068]	endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; trans-Golgi network membrane [GO:0032588]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; trans-Golgi network membrane [GO:0032588]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagosome assembly [GO:0000045]; cellular response to type II interferon [GO:0071346]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; phagosome maturation [GO:0090382]; retrograde transport, plasma membrane to Golgi [GO:0035526]; virion assembly [GO:0019068]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:18664496}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:17562788}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:21255211}.
Q86YS7	reviewed	C2CD5_HUMAN	C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa)	C2CD5 CDP138 KIAA0528	Homo sapiens (Human)	1000	FUNCTION: Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}.		insulin receptor signaling pathway [GO:0008286]; intracellular protein transmembrane transport [GO:0065002]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of vesicle fusion [GO:0031340]; protein localization to plasma membrane [GO:0072659]	cell cortex [GO:0005938]; centriolar satellite [GO:0034451]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]	cell cortex [GO:0005938]; centriolar satellite [GO:0034451]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; insulin receptor signaling pathway [GO:0008286]; intracellular protein transmembrane transport [GO:0065002]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of vesicle fusion [GO:0031340]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:21907143}. Cytoplasm, cell cortex {ECO:0000269|PubMed:21907143}. Cell membrane {ECO:0000269|PubMed:21907143}. Cell projection, ruffle {ECO:0000269|PubMed:21907143}. Note=Dynamically associated with GLUT4-containing glucose storage vesicles (GSV) and plasma membrane in response to insulin stimulation.
Q86YT5	reviewed	S13A5_HUMAN	Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5)	SLC13A5 NACT	Homo sapiens (Human)	568	FUNCTION: High-affinity sodium/citrate cotransporter that mediates the entry of citrate into cells, which is a critical participant of biochemical pathways (PubMed:12445824, PubMed:26324167, PubMed:26384929, PubMed:30054523, PubMed:33597751, PubMed:12826022). May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis (PubMed:12826022). Transports citrate into the cell in a Na(+)-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form (PubMed:12445824, PubMed:26324167, PubMed:26384929, PubMed:30054523, PubMed:33597751, PubMed:12826022). Can recognize succinate as a substrate, but its affinity for succinate is several fold lower than for citrate (PubMed:26324167). The stoichiometry is probably 4 Na(+) for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic (PubMed:12445824, PubMed:12826022). Involved in the regulation of citrate levels in the brain (By similarity). {ECO:0000250|UniProtKB:Q67BT3, ECO:0000269|PubMed:12445824, ECO:0000269|PubMed:12826022, ECO:0000269|PubMed:26324167, ECO:0000269|PubMed:26384929, ECO:0000269|PubMed:30054523, ECO:0000269|PubMed:33597751}.		alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; citrate transport [GO:0015746]; fumarate transport [GO:0015741]; oxaloacetate transport [GO:0015729]; succinate transport [GO:0015744]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	citrate transmembrane transporter activity [GO:0015137]; identical protein binding [GO:0042802]; organic acid:sodium symporter activity [GO:0005343]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; citrate transmembrane transporter activity [GO:0015137]; identical protein binding [GO:0042802]; organic acid:sodium symporter activity [GO:0005343]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]; alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; citrate transport [GO:0015746]; fumarate transport [GO:0015741]; oxaloacetate transport [GO:0015729]; succinate transport [GO:0015744]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26384929, ECO:0000269|PubMed:30054523}; Multi-pass membrane protein {ECO:0000255}.
Q86YT6	reviewed	MIB1_HUMAN	E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2)	MIB1 DIP1 KIAA1323 ZZANK2	Homo sapiens (Human)	1006	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}.	MISCELLANEOUS: In epilepsy brain tissue, levels of expression are increased in the cytoplasm and microsomal fractions (endoplasmic reticulum).	blood vessel development [GO:0001568]; endocytosis [GO:0006897]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; negative regulation of neuron differentiation [GO:0045665]; neural tube formation [GO:0001841]; neuron differentiation [GO:0030182]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; protein ubiquitination [GO:0016567]; somitogenesis [GO:0001756]; ubiquitin-dependent protein catabolic process [GO:0006511]	centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; blood vessel development [GO:0001568]; endocytosis [GO:0006897]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; negative regulation of neuron differentiation [GO:0045665]; neural tube formation [GO:0001841]; neuron differentiation [GO:0030182]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; protein ubiquitination [GO:0016567]; somitogenesis [GO:0001756]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24121310}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24121310}. Cell membrane {ECO:0000250}. Note=Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. {ECO:0000250}.
Q86YT9	reviewed	JAML_HUMAN	Junctional adhesion molecule-like (Adhesion molecule interacting with CXADR antigen 1) (Dendritic cell-specific protein CREA7-1)	JAML AMICA1 UNQ722/PRO1387	Homo sapiens (Human)	394	FUNCTION: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269|PubMed:12869515, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:18948633, ECO:0000269|PubMed:19064666}.		gamma-delta T cell activation [GO:0046629]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; monocyte extravasation [GO:0035696]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]	bicellular tight junction [GO:0005923]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; protein homodimerization activity [GO:0042803]	bicellular tight junction [GO:0005923]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; protein homodimerization activity [GO:0042803]; gamma-delta T cell activation [GO:0046629]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; monocyte extravasation [GO:0035696]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12869515}; Single-pass type I membrane protein {ECO:0000269|PubMed:12869515}. Cell junction {ECO:0000269|PubMed:12869515}. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).
Q86YV0	reviewed	RASL3_HUMAN	RAS protein activator like-3	RASAL3	Homo sapiens (Human)	1011	FUNCTION: Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}.		negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of NK T cell proliferation [GO:0051142]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of membrane [GO:0098562]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of membrane [GO:0098562]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of NK T cell proliferation [GO:0051142]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25652366}. Cytoplasm, cell cortex {ECO:0000269|PubMed:25652366}.
Q86YV5	reviewed	PRAG1_HUMAN	Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223)	PRAG1 SGK223	Homo sapiens (Human)	1406	FUNCTION: Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}.		cell migration [GO:0016477]; negative regulation of neuron projection development [GO:0010977]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of Notch signaling pathway [GO:0008593]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; cell migration [GO:0016477]; negative regulation of neuron projection development [GO:0010977]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of Notch signaling pathway [GO:0008593]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:D3ZMK9}. Cell junction, focal adhesion {ECO:0000269|PubMed:27116701}. Nucleus {ECO:0000250|UniProtKB:Q571I4}. Note=Colocalized with NOTCH1 in the nucleus. {ECO:0000250|UniProtKB:Q571I4}.
Q86YV9	reviewed	HPS6_HUMAN	BLOC-2 complex member HPS6 (Hermansky-Pudlak syndrome 6 protein) (Ruby-eye protein homolog) (Ru)	HPS6	Homo sapiens (Human)	775	FUNCTION: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (PubMed:17041891). Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning (PubMed:25189619). {ECO:0000269|PubMed:17041891, ECO:0000269|PubMed:25189619}.		blood coagulation [GO:0007596]; intracellular transport [GO:0046907]; lysosome localization [GO:0032418]; melanosome assembly [GO:1903232]; organelle organization [GO:0006996]; platelet dense granule organization [GO:0060155]; protein localization to membrane [GO:0072657]	BLOC-2 complex [GO:0031084]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]	GTP-dependent protein binding [GO:0030742]; small GTPase binding [GO:0031267]	BLOC-2 complex [GO:0031084]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; GTP-dependent protein binding [GO:0030742]; small GTPase binding [GO:0031267]; blood coagulation [GO:0007596]; intracellular transport [GO:0046907]; lysosome localization [GO:0032418]; melanosome assembly [GO:1903232]; organelle organization [GO:0006996]; platelet dense granule organization [GO:0060155]; protein localization to membrane [GO:0072657]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:15030569}. Cytoplasm, cytosol {ECO:0000269|PubMed:15030569}. Early endosome membrane {ECO:0000269|PubMed:16837549}. Lysosome membrane {ECO:0000269|PubMed:25189619}.
Q86YW0	reviewed	PLCZ1_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-zeta-1) (Phospholipase C-zeta-1) (PLC-zeta-1) (Testis-development protein NYD-SP27)	PLCZ1	Homo sapiens (Human)	608	FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250|UniProtKB:Q8K4D7, ECO:0000269|PubMed:12416999, ECO:0000269|PubMed:14697805, ECO:0000269|PubMed:15579586, ECO:0000269|PubMed:26721930, ECO:0000305}.		calcium ion transport [GO:0006816]; egg activation [GO:0007343]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of cytosolic calcium ion concentration involved in egg activation [GO:0060470]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; pronucleus [GO:0045120]; sperm head [GO:0061827]	calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-5-phosphate binding [GO:0010314]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; pronucleus [GO:0045120]; sperm head [GO:0061827]; calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-5-phosphate binding [GO:0010314]; calcium ion transport [GO:0006816]; egg activation [GO:0007343]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of cytosolic calcium ion concentration involved in egg activation [GO:0060470]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8K4D7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8K4D7}. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). {ECO:0000250|UniProtKB:Q8K4D7}.
Q86YW5	reviewed	TRML1_HUMAN	Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1)	TREML1 TLT1 UNQ1825/PRO3438	Homo sapiens (Human)	311	FUNCTION: Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}.		calcium-mediated signaling [GO:0019722]; innate immune response [GO:0045087]; platelet activation [GO:0030168]	cell surface [GO:0009986]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]	transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; transmembrane signaling receptor activity [GO:0004888]; calcium-mediated signaling [GO:0019722]; innate immune response [GO:0045087]; platelet activation [GO:0030168]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15100151}; Single-pass type I membrane protein {ECO:0000269|PubMed:15100151}. Cytoplasm {ECO:0000269|PubMed:15100151}. Note=Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).
Q86YW7	reviewed	GPHB5_HUMAN	Glycoprotein hormone beta-5 (Thyrostimulin subunit beta)	GPHB5 GPB5 ZLUT1	Homo sapiens (Human)	130	FUNCTION: Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. {ECO:0000269|PubMed:12045258, ECO:0000269|PubMed:16210345}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of thyroid hormone mediated signaling pathway [GO:0002155]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	hormone activity [GO:0005179]; protein heterodimerization activity [GO:0046982]; thyrotropin-releasing hormone receptor binding [GO:0031531]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; protein heterodimerization activity [GO:0046982]; thyrotropin-releasing hormone receptor binding [GO:0031531]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of thyroid hormone mediated signaling pathway [GO:0002155]	SUBCELLULAR LOCATION: Secreted.
Q86YW9	reviewed	MD12L_HUMAN	Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like)	MED12L KIAA1635 TNRC11L TRALP TRALPUSH PRO0314	Homo sapiens (Human)	2145	FUNCTION: May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.		positive regulation of transcription by RNA polymerase II [GO:0045944]	mediator complex [GO:0016592]	beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713]	mediator complex [GO:0016592]; beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86YZ3	reviewed	HORN_HUMAN	Hornerin	HRNR S100A18	Homo sapiens (Human)	2850	FUNCTION: Component of the epidermal cornified cell envelopes. {ECO:0000269|PubMed:21282207}.		cell envelope organization [GO:0043163]; establishment of skin barrier [GO:0061436]; keratinization [GO:0031424]	azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914]	azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914]; cell envelope organization [GO:0043163]; establishment of skin barrier [GO:0061436]; keratinization [GO:0031424]	SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000269|PubMed:21282207}. Note=Found in keratohyalin granules in the granular cells of the epidermis.
Q86Z02	reviewed	HIPK1_HUMAN	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2)	HIPK1 KIAA0630 MYAK NBAK2	Homo sapiens (Human)	1210	FUNCTION: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}.		adherens junction assembly [GO:0034333]; anterior/posterior pattern specification [GO:0009952]; cell population proliferation [GO:0008283]; definitive hemopoiesis [GO:0060216]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; endothelial cell apoptotic process [GO:0072577]; extrinsic apoptotic signaling pathway [GO:0097191]; eye development [GO:0001654]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; iris morphogenesis [GO:0061072]; lens induction in camera-type eye [GO:0060235]; neuron differentiation [GO:0030182]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; protein phosphorylation [GO:0006468]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; retina layer formation [GO:0010842]; smoothened signaling pathway [GO:0007224]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; adherens junction assembly [GO:0034333]; anterior/posterior pattern specification [GO:0009952]; cell population proliferation [GO:0008283]; definitive hemopoiesis [GO:0060216]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; endothelial cell apoptotic process [GO:0072577]; extrinsic apoptotic signaling pathway [GO:0097191]; eye development [GO:0001654]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; iris morphogenesis [GO:0061072]; lens induction in camera-type eye [GO:0060235]; neuron differentiation [GO:0030182]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; protein phosphorylation [GO:0006468]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; retina layer formation [GO:0010842]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:18219322, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:28289210}. Cytoplasm {ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:18219322, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:28289210}. Nucleus speckle {ECO:0000269|PubMed:16390825}. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation. {ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:18219322}.
Q86Z14	reviewed	KLOTB_HUMAN	Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)	KLB	Homo sapiens (Human)	1044	FUNCTION: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). {ECO:0000250}.		carbohydrate metabolic process [GO:0005975]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]	plasma membrane [GO:0005886]	fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor binding [GO:0005104]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	plasma membrane [GO:0005886]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor binding [GO:0005104]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; carbohydrate metabolic process [GO:0005975]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Q86Z20	reviewed	CC125_HUMAN	Coiled-coil domain-containing protein 125 (Protein kenae)	CCDC125 KENAE	Homo sapiens (Human)	511	FUNCTION: May be involved in the regulation of cell migration. {ECO:0000269|PubMed:19787194}.		activation of GTPase activity [GO:0090630]; negative regulation of cell motility [GO:2000146]; negative regulation of Rho protein signal transduction [GO:0035024]	cytoplasm [GO:0005737]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; activation of GTPase activity [GO:0090630]; negative regulation of cell motility [GO:2000146]; negative regulation of Rho protein signal transduction [GO:0035024]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19787194}.
Q86Z23	reviewed	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	C1QL4 CTRP11	Homo sapiens (Human)	238	FUNCTION: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity). {ECO:0000250}.		ERK1 and ERK2 cascade [GO:0070371]; fibroblast proliferation [GO:0048144]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147]	collagen trimer [GO:0005581]; extracellular space [GO:0005615]	identical protein binding [GO:0042802]	collagen trimer [GO:0005581]; extracellular space [GO:0005615]; identical protein binding [GO:0042802]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast proliferation [GO:0048144]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q8HWS3	reviewed	RFX6_HUMAN	DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1)	RFX6 RFXDC1	Homo sapiens (Human)	928	FUNCTION: Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100). {ECO:0000269|PubMed:20148032, ECO:0000269|PubMed:25497100}.		endocrine pancreas development [GO:0031018]; glucose homeostasis [GO:0042593]; pancreatic A cell differentiation [GO:0003310]; pancreatic D cell differentiation [GO:0003311]; pancreatic epsilon cell differentiation [GO:0090104]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; type B pancreatic cell differentiation [GO:0003309]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; endocrine pancreas development [GO:0031018]; glucose homeostasis [GO:0042593]; pancreatic A cell differentiation [GO:0003310]; pancreatic D cell differentiation [GO:0003311]; pancreatic epsilon cell differentiation [GO:0090104]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; type B pancreatic cell differentiation [GO:0003309]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25497100}.
Q8IU54	reviewed	IFNL1_HUMAN	Interferon lambda-1 (IFN-lambda-1) (Cytokine Zcyto21) (Interleukin-29) (IL-29)	IFNL1 IL29 ZCYTO21	Homo sapiens (Human)	200	FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.		cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of memory T cell differentiation [GO:0043381]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of immune response [GO:0050778]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via JAK-STAT [GO:0007259]; type III interferon-mediated signaling pathway [GO:0038196]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-28 receptor complex [GO:0032002]	cytokine activity [GO:0005125]; interleukin-28 receptor binding [GO:0032003]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-28 receptor complex [GO:0032002]; cytokine activity [GO:0005125]; interleukin-28 receptor binding [GO:0032003]; signaling receptor binding [GO:0005102]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of memory T cell differentiation [GO:0043381]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of immune response [GO:0050778]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via JAK-STAT [GO:0007259]; type III interferon-mediated signaling pathway [GO:0038196]	SUBCELLULAR LOCATION: Secreted.
Q8IU57	reviewed	INLR1_HUMAN	Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)	IFNLR1 IL28RA LICR2	Homo sapiens (Human)	520	FUNCTION: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210, ECO:0000269|PubMed:12521379}.		cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; mucosal immune response [GO:0002385]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cellular respiration [GO:1901857]; regulation of defense response to virus by host [GO:0050691]; response to type III interferon [GO:0034342]; type III interferon-mediated signaling pathway [GO:0038196]	interleukin-28 receptor complex [GO:0032002]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cytokine receptor activity [GO:0004896]	interleukin-28 receptor complex [GO:0032002]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cytokine receptor activity [GO:0004896]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; mucosal immune response [GO:0002385]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cellular respiration [GO:1901857]; regulation of defense response to virus by host [GO:0050691]; response to type III interferon [GO:0034342]; type III interferon-mediated signaling pathway [GO:0038196]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q8IU60	reviewed	DCP2_HUMAN	m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc)	DCP2 NUDT20	Homo sapiens (Human)	420	FUNCTION: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). {ECO:0000269|PubMed:12218187, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12486012, ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:26098573, ECO:0000269|PubMed:28002401}.		deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; histone mRNA catabolic process [GO:0071044]; mRNA catabolic process [GO:0006402]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of mRNA stability [GO:0043488]; regulation of telomerase RNA localization to Cajal body [GO:1904872]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RISC complex [GO:0016442]	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; 5'-3' RNA exonuclease activity [GO:0004534]; manganese ion binding [GO:0030145]; RNA exonuclease activity, producing 5'-phosphomonoesters [GO:0016896]; telomerase RNA binding [GO:0070034]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RISC complex [GO:0016442]; 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; 5'-3' RNA exonuclease activity [GO:0004534]; manganese ion binding [GO:0030145]; RNA exonuclease activity, producing 5'-phosphomonoesters [GO:0016896]; telomerase RNA binding [GO:0070034]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; histone mRNA catabolic process [GO:0071044]; mRNA catabolic process [GO:0006402]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of mRNA stability [GO:0043488]; regulation of telomerase RNA localization to Cajal body [GO:1904872]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:15067023, ECO:0000269|PubMed:15273322, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:20616046}. Nucleus {ECO:0000269|PubMed:15273322}. Note=Predominantly cytoplasmic, in processing bodies (PB) (PubMed:15273322). A minor amount is nuclear (PubMed:15273322). {ECO:0000269|PubMed:15273322, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:20616046}.
Q8IU68	reviewed	TMC8_HUMAN	Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2)	TMC8 EVER2 EVIN2	Homo sapiens (Human)	726	FUNCTION: Probable ion channel. {ECO:0000250}.		intracellular zinc ion homeostasis [GO:0006882]; negative regulation of protein binding [GO:0032091]; negative regulation of protein-containing complex assembly [GO:0031333]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	mechanosensitive monoatomic ion channel activity [GO:0008381]; protein sequestering activity [GO:0140311]; tumor necrosis factor binding [GO:0043120]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; mechanosensitive monoatomic ion channel activity [GO:0008381]; protein sequestering activity [GO:0140311]; tumor necrosis factor binding [GO:0043120]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of protein binding [GO:0032091]; negative regulation of protein-containing complex assembly [GO:0031333]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12426567}; Multi-pass membrane protein {ECO:0000269|PubMed:12426567}.
Q8IU80	reviewed	TMPS6_HUMAN	Transmembrane protease serine 6 (EC 3.4.21.-) (Matriptase-2)	TMPRSS6 UNQ354/PRO618	Homo sapiens (Human)	811	FUNCTION: Membrane-bound serine protease (PubMed:18976966, PubMed:20518742, PubMed:25156943, PubMed:25588876). Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed:25156943, PubMed:18408718, PubMed:18976966). {ECO:0000269|PubMed:18408718, ECO:0000269|PubMed:18976966, ECO:0000269|PubMed:20518742, ECO:0000269|PubMed:25156943, ECO:0000269|PubMed:25588876, ECO:0000303|PubMed:25156943}.		BMP signaling pathway [GO:0030509]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; intracellular iron ion homeostasis [GO:0006879]; membrane protein proteolysis [GO:0033619]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; self proteolysis [GO:0097264]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; BMP signaling pathway [GO:0030509]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; intracellular iron ion homeostasis [GO:0006879]; membrane protein proteolysis [GO:0033619]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; self proteolysis [GO:0097264]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18976966, ECO:0000269|PubMed:20518742, ECO:0000269|PubMed:25588876}; Single-pass type II membrane protein {ECO:0000269|PubMed:20518742}. Note=The processed, activated two-chains form is released in the extracellular space. {ECO:0000269|PubMed:25156943}.
Q8IU81	reviewed	I2BP1_HUMAN	Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1)	IRF2BP1	Homo sapiens (Human)	584	FUNCTION: Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; protein polyubiquitination [GO:0000209]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein polyubiquitination [GO:0000209]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12799427}.
Q8IU85	reviewed	KCC1D_HUMAN	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK)	CAMK1D CAMKID	Homo sapiens (Human)	385	FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}.		inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of neuron projection development [GO:0010976]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phagocytosis [GO:0050766]; positive regulation of respiratory burst [GO:0060267]; regulation of dendrite development [GO:0050773]; regulation of granulocyte chemotaxis [GO:0071622]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of neuron projection development [GO:0010976]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phagocytosis [GO:0050766]; positive regulation of respiratory burst [GO:0060267]; regulation of dendrite development [GO:0050773]; regulation of granulocyte chemotaxis [GO:0071622]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.
Q8IU89	reviewed	CERS3_HUMAN	Ceramide synthase 3 (CerS3) (Dihydroceramide synthase 3) (LAG1 longevity assurance homolog 3) (Sphingosine N-acyltransferase CERS3) (EC 2.3.1.24) (Ultra-long-chain ceramide synthase CERS3) (EC 2.3.1.298) (Very-long-chain ceramide synthase CERS3) (EC 2.3.1.297)	CERS3 LASS3	Homo sapiens (Human)	383	FUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22) (PubMed:17977534, PubMed:22038835, PubMed:26887952). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:22038835, PubMed:26887952). It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:23754960). {ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:22038835, ECO:0000269|PubMed:23754960, ECO:0000269|PubMed:26887952}.		ceramide biosynthetic process [GO:0046513]; cornification [GO:0070268]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; sphingolipid biosynthetic process [GO:0030148]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291]; ceramide biosynthetic process [GO:0046513]; cornification [GO:0070268]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1A3B0}; Multi-pass membrane protein {ECO:0000255}.
Q8IU99	reviewed	CAHM1_HUMAN	Calcium homeostasis modulator protein 1 (Protein FAM26C)	CALHM1 FAM26C	Homo sapiens (Human)	346	FUNCTION: Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes (By similarity). Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (By similarity). Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (By similarity). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration (PubMed:22711817, PubMed:23300080). Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions (PubMed:22711817). Acts as an activator of the ERK1 and ERK2 cascade (PubMed:23345406). Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (PubMed:21574960). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner (PubMed:18585350). {ECO:0000250|UniProtKB:D3Z291, ECO:0000269|PubMed:18585350, ECO:0000269|PubMed:21574960, ECO:0000269|PubMed:22711817, ECO:0000269|PubMed:23300080, ECO:0000269|PubMed:23345406}.		ATP transport [GO:0015867]; monoatomic cation transport [GO:0006812]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to stimulus [GO:0050896]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917]	basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	calcium activated cation channel activity [GO:0005227]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic ion channel activity [GO:0005244]	basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; calcium activated cation channel activity [GO:0005227]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic ion channel activity [GO:0005244]; ATP transport [GO:0015867]; monoatomic cation transport [GO:0006812]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to stimulus [GO:0050896]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:18585350, ECO:0000269|PubMed:22711817, ECO:0000269|PubMed:23300080}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18585350}; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:D3Z291}. Note=Colocalizes with HSPA5 at the endoplasmic reticulum (PubMed:18585350). Localizes to the basolateral membrane of epithelial cells including taste cells (By similarity). {ECO:0000250|UniProtKB:D3Z291, ECO:0000269|PubMed:18585350}.
Q8IUA7	reviewed	ABCA9_HUMAN	ATP-binding cassette sub-family A member 9 (EC 7.6.2.-)	ABCA9	Homo sapiens (Human)	1624	FUNCTION: Transporter that may play a role in monocyte differentiation and lipid transport and homeostasis. {ECO:0000305|PubMed:12150964}.		lipid transport [GO:0006869]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8IUB9	reviewed	KR191_HUMAN	Keratin-associated protein 19-1 (High tyrosine-glycine keratin-associated protein 19.1)	KRTAP19-1 KAP19.1 KRTAP19.1	Homo sapiens (Human)	90	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q8IUC1	reviewed	KR111_HUMAN	Keratin-associated protein 11-1 (High sulfur keratin-associated protein 11.1)	KRTAP11-1 KAP11.1 KRTAP11.1	Homo sapiens (Human)	163	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; keratin filament [GO:0045095]; structural molecule activity [GO:0005198]	
Q8IUC2	reviewed	KRA81_HUMAN	Keratin-associated protein 8-1 (High glycine-tyrosine keratin-associated protein 8.1)	KRTAP8-1 KAP8.1 KRTAP8.1	Homo sapiens (Human)	63	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q8IUC3	reviewed	KRA71_HUMAN	Keratin-associated protein 7-1 (High tyrosine-glycine keratin-associated protein 7.1)	KRTAP7-1 KAP7.1 KRTAP7.1	Homo sapiens (Human)	87	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
Q8IUC4	reviewed	RHPN2_HUMAN	Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE)	RHPN2	Homo sapiens (Human)	686	FUNCTION: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}.		glomerular filtration [GO:0003094]; negative regulation of stress fiber assembly [GO:0051497]; signal transduction [GO:0007165]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; glomerular filtration [GO:0003094]; negative regulation of stress fiber assembly [GO:0051497]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12473120}.
Q8IUC6	reviewed	TCAM1_HUMAN	TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)	TICAM1 PRVTIRB TRIF	Homo sapiens (Human)	712	FUNCTION: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (By similarity). {ECO:0000250|UniProtKB:Q80UF7, ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:14739303, ECO:0000269|PubMed:25636800}.		apoptotic signaling pathway [GO:0097190]; B cell proliferation [GO:0042100]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; regulation of protein-containing complex assembly [GO:0043254]; response to exogenous dsRNA [GO:0043330]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	autophagosome [GO:0005776]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; ripoptosome [GO:0097342]	molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]	autophagosome [GO:0005776]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; ripoptosome [GO:0097342]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; apoptotic signaling pathway [GO:0097190]; B cell proliferation [GO:0042100]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; regulation of protein-containing complex assembly [GO:0043254]; response to exogenous dsRNA [GO:0043330]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:21695056}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q80UF7}. Mitochondrion {ECO:0000250|UniProtKB:Q80UF7}. Note=Colocalizes with UBQLN1 in the autophagosome (PubMed:21695056). Colocalizes in the cytosol with DDX1, DDX21 and DHX36. Colocalizes in the mitochondria with DDX1 and poly(I:C) RNA ligand. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity). {ECO:0000250|UniProtKB:Q80UF7, ECO:0000269|PubMed:21695056}.
Q8IUC8	reviewed	GLT13_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13)	GALNT13 KIAA1918	Homo sapiens (Human)	556	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor (PubMed:12407114, PubMed:22186971). Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O-glycan core structures (PubMed:12407114). Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system. May promote neurogenesis through glycosylation and stabilization of PDPN (PubMed:12407114, PubMed:22186971) (By similarity). {ECO:0000250|UniProtKB:Q8CF93, ECO:0000269|PubMed:12407114, ECO:0000269|PubMed:22186971}.; FUNCTION: [Isoform 1]: Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC, specifically on Thr-3 of non-glycosylated MUC5AC peptide, on Thr-12 and Thr-13 of preglycosylated MUC5AC at Thr-3 (MUC5AC-3), on Thr-3 of preglycosylated MUC5AC at Thr-13 (MUC5AC-13) and on Thr-12 of preglycosylated MUC5AC at Thr-3 and Thr-13 (MUC5AC-3,13). Transfers GalNAc to three consecutive serine/threonine residues on SDC3 forming a triplet-Tn epitope expressed in Purkinje cells of the developing brain. {ECO:0000269|PubMed:12407114, ECO:0000269|PubMed:22186971}.; FUNCTION: [Isoform 3]: Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC, specifically on Thr-3 of non-glycosylated MUC5AC peptide, on Thr-12 and Thr-13 of preglycosylated MUC5AC at Thr-3 (MUC5AC-3), on Thr-3 of preglycosylated MUC5AC at Thr-13 (MUC5AC-13) and on Thr-12 of preglycosylated MUC5AC at Thr-3 and Thr-13 (MUC5AC-3,13). {ECO:0000269|PubMed:22186971}.		O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q8IUD2	reviewed	RB6I2_HUMAN	ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)	ERC1 ELKS KIAA1081 RAB6IP2	Homo sapiens (Human)	1116	FUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	I-kappaB phosphorylation [GO:0007252]; maintenance of presynaptic active zone structure [GO:0048790]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein transport [GO:0015031]; regulation of DNA-templated transcription [GO:0006355]; regulation of synaptic plasticity [GO:0048167]; retrograde transport, endosome to Golgi [GO:0042147]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoskeleton of presynaptic active zone [GO:0048788]; Golgi membrane [GO:0000139]; IkappaB kinase complex [GO:0008385]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]	cadherin binding [GO:0045296]; PDZ domain binding [GO:0030165]; small GTPase binding [GO:0031267]; structural constituent of presynaptic active zone [GO:0098882]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoskeleton of presynaptic active zone [GO:0048788]; Golgi membrane [GO:0000139]; IkappaB kinase complex [GO:0008385]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; cadherin binding [GO:0045296]; PDZ domain binding [GO:0030165]; small GTPase binding [GO:0031267]; structural constituent of presynaptic active zone [GO:0098882]; I-kappaB phosphorylation [GO:0007252]; maintenance of presynaptic active zone structure [GO:0048790]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein transport [GO:0015031]; regulation of DNA-templated transcription [GO:0006355]; regulation of synaptic plasticity [GO:0048167]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27224062}. Cytoplasm {ECO:0000250|UniProtKB:Q811U3}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q811U3}. Note=Recruited on Golgi membranes by RAB6A in a GTP-dependent manner (By similarity). {ECO:0000250}.
Q8IUD6	reviewed	RN135_HUMAN	E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135)	RNF135 L13	Homo sapiens (Human)	432	FUNCTION: E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531). Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:19017631, PubMed:21147464, PubMed:28469175, PubMed:31006531). Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531). This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (PubMed:28469175, PubMed:31006531). {ECO:0000269|PubMed:19017631, ECO:0000269|PubMed:19484123, ECO:0000269|PubMed:21147464, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:31006531, ECO:0000305|PubMed:31006531}.		antiviral innate immune response [GO:0140374]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; protein homooligomerization [GO:0051260]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of innate immune response [GO:0045088]; RIG-I signaling pathway [GO:0039529]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]; RIG-I binding [GO:0039552]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]; RIG-I binding [GO:0039552]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; antiviral innate immune response [GO:0140374]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; protein homooligomerization [GO:0051260]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of innate immune response [GO:0045088]; RIG-I signaling pathway [GO:0039529]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19484123, ECO:0000269|PubMed:23950712}. Cytoplasm, Stress granule {ECO:0000269|PubMed:23950712}.
Q8IUE6	reviewed	H2A2B_HUMAN	Histone H2A type 2-B (H2A-clustered histone 21)	H2AC21 HIST2H2AB	Homo sapiens (Human)	130	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.			extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q8IUF8	reviewed	RIOX2_HUMAN	Ribosomal oxygenase 2 (60S ribosomal protein L27a histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) (EC 1.14.11.79) (Histone lysine demethylase MINA) (MYC-induced nuclear antigen) (Mineral dust-induced gene protein) (Nucleolar protein 52) (Ribosomal oxygenase MINA) (ROX)	RIOX2 MDIG MINA MINA53 NO52	Homo sapiens (Human)	465	FUNCTION: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:14695334, ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15819408, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:17317935, ECO:0000269|PubMed:19502796, ECO:0000269|PubMed:23103944}.		ribosome biogenesis [GO:0042254]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K4 demethylase activity [GO:0032453]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; peptidyl-histidine dioxygenase activity [GO:0036139]; transcription corepressor activity [GO:0003714]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K4 demethylase activity [GO:0032453]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; peptidyl-histidine dioxygenase activity [GO:0036139]; transcription corepressor activity [GO:0003714]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:15819408}. Nucleus, nucleolus {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:15819408}.
Q8IUG1	reviewed	KRA13_HUMAN	Keratin-associated protein 1-3 (Keratin-associated protein 1.8) (Keratin-associated protein 1.9)	KRTAP1-3 B2B KAP1.2 KAP1.3 KAP1.8 KAP1.9 KRATP1.9 KRTAP1.8	Homo sapiens (Human)	167	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]	
Q8IUG5	reviewed	MY18B_HUMAN	Unconventional myosin-XVIIIb	MYO18B	Homo sapiens (Human)	2567	FUNCTION: May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.	MISCELLANEOUS: Frequently deleted, mutated, and hypermethylated in lung cancers.	actomyosin structure organization [GO:0031032]; cardiac muscle cell development [GO:0055013]; in utero embryonic development [GO:0001701]; vasculogenesis [GO:0001570]	cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; nucleus [GO:0005634]; unconventional myosin complex [GO:0016461]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]	cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; nucleus [GO:0005634]; unconventional myosin complex [GO:0016461]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]; actomyosin structure organization [GO:0031032]; cardiac muscle cell development [GO:0055013]; in utero embryonic development [GO:0001701]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Note=Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.
Q8IUH3	reviewed	RBM45_HUMAN	RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45)	RBM45 DRB1 DRBP1	Homo sapiens (Human)	476	FUNCTION: RNA-binding protein with binding specificity for poly(C). May play an important role in neural development. {ECO:0000250|UniProtKB:Q8CFD1, ECO:0000269|PubMed:12220514}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	cell differentiation [GO:0030154]; nervous system development [GO:0007399]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12220514}. Nucleus {ECO:0000269|PubMed:12220514}. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.
Q8IUH4	reviewed	ZDH13_HUMAN	Palmitoyltransferase ZDHHC13 (EC 2.3.1.225) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin-interacting protein HIP3RP) (Putative MAPK-activating protein PM03) (Putative NF-kappa-B-activating protein 209) (Zinc finger DHHC domain-containing protein 13) (DHHC-13)	ZDHHC13 HIP14L HIP3RP	Homo sapiens (Human)	622	FUNCTION: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (By similarity). Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport. {ECO:0000250|UniProtKB:Q9CWU2}.		positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; membrane [GO:0016020]	magnesium ion transmembrane transporter activity [GO:0015095]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; membrane [GO:0016020]; magnesium ion transmembrane transporter activity [GO:0015095]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9CWU2}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9CWU2}; Multi-pass membrane protein {ECO:0000255}. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles. {ECO:0000250|UniProtKB:Q9CWU2}.
Q8IUH5	reviewed	ZDH17_HUMAN	Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (DHHC17) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17)	ZDHHC17 HIP14 HIP3 HYPH KIAA0946 HSPC294	Homo sapiens (Human)	632	FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:15489887, PubMed:15603740, PubMed:24705354, PubMed:27911442, PubMed:28757145). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (PubMed:24705354). Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation (PubMed:27911442). {ECO:0000250|UniProtKB:Q80TN5, ECO:0000269|PubMed:12393793, ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603740, ECO:0000269|PubMed:18794299, ECO:0000269|PubMed:19139280, ECO:0000269|PubMed:24705354, ECO:0000269|PubMed:27911442, ECO:0000269|PubMed:28757145}.		axonogenesis [GO:0007409]; lipoprotein transport [GO:0042953]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein palmitoylation [GO:0018345]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]; regulation of programmed cell death [GO:0043067]	cell projection [GO:0042995]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; presynaptic membrane [GO:0042734]	identical protein binding [GO:0042802]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; signaling receptor binding [GO:0005102]	cell projection [GO:0042995]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; presynaptic membrane [GO:0042734]; identical protein binding [GO:0042802]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; signaling receptor binding [GO:0005102]; axonogenesis [GO:0007409]; lipoprotein transport [GO:0042953]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein palmitoylation [GO:0018345]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]; regulation of programmed cell death [GO:0043067]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15603740, ECO:0000269|PubMed:18794299}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18794299}; Multi-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000269|PubMed:18032660}; Multi-pass membrane protein {ECO:0000255}. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles. {ECO:0000269|PubMed:18794299}.
Q8IUH8	reviewed	SPP2C_HUMAN	Signal peptide peptidase-like 2C (SPP-like 2C) (SPPL2c) (EC 3.4.23.-) (Intramembrane protease 5) (IMP-5)	SPPL2C IMP5	Homo sapiens (Human)	684	FUNCTION: Sperm-specific intramembrane-cleaving aspartic protease (I-CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins (PubMed:30733281). In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage (By similarity). During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome (PubMed:30733281). {ECO:0000250|UniProtKB:A2A6C4, ECO:0000269|PubMed:30733281}.; FUNCTION: In round spermatids, acts as a scaffold protein supporting FREY1 in IZUMO1 recruitment at the endoplasmic reticulum membrane and coordination of IZUMO1 complex assembly. Stabilizes FREY1 at the endoplasmic reticulum membrane through interaction. May recruit IZUMO1 interaction partners. {ECO:0000250|UniProtKB:A2A6C4}.		acrosome assembly [GO:0001675]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; intracellular calcium ion homeostasis [GO:0006874]; membrane protein proteolysis [GO:0033619]; sperm-egg recognition [GO:0035036]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum membrane [GO:0005789]; Golgi-associated vesicle membrane [GO:0030660]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]	aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum membrane [GO:0005789]; Golgi-associated vesicle membrane [GO:0030660]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; acrosome assembly [GO:0001675]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; intracellular calcium ion homeostasis [GO:0006874]; membrane protein proteolysis [GO:0033619]; sperm-egg recognition [GO:0035036]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:30733280, ECO:0000269|PubMed:30733281}; Multi-pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000269|PubMed:15385547, ECO:0000269|PubMed:16829952}.
Q8IUI8	reviewed	CRLF3_HUMAN	Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48)	CRLF3 CREME9 CRLM9 CYTOR4 P48	Homo sapiens (Human)	442	FUNCTION: May play a role in the negative regulation of cell cycle progression. {ECO:0000269|PubMed:19427400}.		negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19427400}. Note=The EGFP- and MYC-tagged protein has been shown to be cytoplasmic. {ECO:0000269|PubMed:19427400}.
Q8IUK5	reviewed	PLDX1_HUMAN	Plexin domain-containing protein 1 (Tumor endothelial marker 3) (Tumor endothelial marker 7)	PLXDC1 TEM3 TEM7	Homo sapiens (Human)	500	FUNCTION: Plays a critical role in endothelial cell capillary morphogenesis. {ECO:0000250}.		angiogenesis [GO:0001525]; spinal cord development [GO:0021510]	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]		bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; angiogenesis [GO:0001525]; spinal cord development [GO:0021510]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.
Q8IUM7	reviewed	NPAS4_HUMAN	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (Class E basic helix-loop-helix protein 79) (bHLHe79) (HLH-PAS transcription factor NXF) (PAS domain-containing protein 10)	NPAS4 BHLHE79 NXF PASD10	Homo sapiens (Human)	802	FUNCTION: Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734). Can activate the CME (CNS midline enhancer) element (PubMed:14701734). {ECO:0000250|UniProtKB:Q8BGD7, ECO:0000269|PubMed:14701734}.		cell differentiation [GO:0030154]; cellular response to corticosterone stimulus [GO:0071386]; excitatory postsynaptic potential [GO:0060079]; inhibitory postsynaptic potential [GO:0060080]; inhibitory synapse assembly [GO:1904862]; learning [GO:0007612]; long-term memory [GO:0007616]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, GABAergic [GO:0032228]; regulation of transcription by RNA polymerase II [GO:0006357]; short-term memory [GO:0007614]; social behavior [GO:0035176]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cell differentiation [GO:0030154]; cellular response to corticosterone stimulus [GO:0071386]; excitatory postsynaptic potential [GO:0060079]; inhibitory postsynaptic potential [GO:0060080]; inhibitory synapse assembly [GO:1904862]; learning [GO:0007612]; long-term memory [GO:0007616]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, GABAergic [GO:0032228]; regulation of transcription by RNA polymerase II [GO:0006357]; short-term memory [GO:0007614]; social behavior [GO:0035176]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BGD7, ECO:0000255|PROSITE-ProRule:PRU00981}.
Q8IUN9	reviewed	CLC10_HUMAN	C-type lectin domain family 10 member A (C-type lectin superfamily member 14) (Macrophage lectin 2) (CD antigen CD301)	CLEC10A CLECSF13 CLECSF14 HML	Homo sapiens (Human)	316	FUNCTION: Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. {ECO:0000269|PubMed:8598452}.		adaptive immune response [GO:0002250]; endocytosis [GO:0006897]; innate immune response [GO:0045087]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; fucose binding [GO:0042806]; mannose binding [GO:0005537]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; fucose binding [GO:0042806]; mannose binding [GO:0005537]; adaptive immune response [GO:0002250]; endocytosis [GO:0006897]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8IUQ0	reviewed	CLVS1_HUMAN	Clavesin-1 (Cellular retinaldehyde-binding protein-like) (Retinaldehyde-binding protein 1-like 1) (clathrin vesicle-associated Sec14 protein 1)	CLVS1 CRALBPL RLBP1L1	Homo sapiens (Human)	354	FUNCTION: Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250, ECO:0000269|PubMed:19651769}.	MISCELLANEOUS: Binding to PtdIns(3,5)P2 is not required for localization.; MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	lysosome organization [GO:0007040]	clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]	clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; lysosome organization [GO:0007040]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:19651769}; Peripheral membrane protein {ECO:0000269|PubMed:19651769}.
Q8IUQ4	reviewed	SIAH1_HUMAN	E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)	SIAH1 HUMSIAH	Homo sapiens (Human)	282	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595, PubMed:28546513, PubMed:32430360, PubMed:33591310). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:10747903, PubMed:11146551, PubMed:11389839, PubMed:11389840, PubMed:11483517, PubMed:11483518, PubMed:11752454, PubMed:12072443). Confers constitutive instability to HIPK2 through proteasomal degradation (PubMed:18536714, PubMed:33591310). It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Has some overlapping function with SIAH2 (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (By similarity). GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1 (PubMed:28546513, PubMed:32430360). {ECO:0000250|UniProtKB:P61092, ECO:0000250|UniProtKB:Q920M9, ECO:0000269|PubMed:10747903, ECO:0000269|PubMed:11146551, ECO:0000269|PubMed:11389839, ECO:0000269|PubMed:11389840, ECO:0000269|PubMed:11483517, ECO:0000269|PubMed:11483518, ECO:0000269|PubMed:11752454, ECO:0000269|PubMed:12072443, ECO:0000269|PubMed:14506261, ECO:0000269|PubMed:14645235, ECO:0000269|PubMed:14654780, ECO:0000269|PubMed:15064394, ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:18536714, ECO:0000269|PubMed:19224863, ECO:0000269|PubMed:20508617, ECO:0000269|PubMed:22483617, ECO:0000269|PubMed:28546513, ECO:0000269|PubMed:32430360, ECO:0000269|PubMed:9334332, ECO:0000269|PubMed:9858595}.		amyloid fibril formation [GO:1990000]; anatomical structure morphogenesis [GO:0009653]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cell cycle [GO:0007049]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]	beta-catenin destruction complex [GO:0030877]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	beta-catenin destruction complex [GO:0030877]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; amyloid fibril formation [GO:1990000]; anatomical structure morphogenesis [GO:0009653]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cell cycle [GO:0007049]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Q8IUR5	reviewed	TMTC1_HUMAN	Protein O-mannosyl-transferase TMTC1 (EC 2.4.1.109) (Transmembrane and TPR repeat-containing protein 1)	TMTC1 ARG99	Homo sapiens (Human)	882	FUNCTION: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. {ECO:0000269|PubMed:28973932}.		protein O-linked mannosylation [GO:0035269]; RNA processing [GO:0006396]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]; protein O-linked mannosylation [GO:0035269]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000305}.
Q8IUR6	reviewed	CRERF_HUMAN	CREB3 regulatory factor (Luman recruitment factor) (LRF)	CREBRF C5orf41	Homo sapiens (Human)	639	FUNCTION: Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci. {ECO:0000269|PubMed:18391022}.		negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of intracellular transport [GO:0032388]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein transport [GO:0051222]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of intracellular transport [GO:0032388]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein transport [GO:0051222]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18391022}. Note=Colocalizes with CREB3 in nuclear foci.
Q8IUR7	reviewed	ARMC8_HUMAN	Armadillo repeat-containing protein 8	ARMC8 S863-2	Homo sapiens (Human)	673	FUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. {ECO:0000269|PubMed:29911972}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; GID complex [GO:0034657]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; ubiquitin ligase complex [GO:0000151]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; GID complex [GO:0034657]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; ubiquitin ligase complex [GO:0000151]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17467196}. Cytoplasm {ECO:0000269|PubMed:17467196}.
Q8IUW3	reviewed	SPA2L_HUMAN	Spermatogenesis-associated protein 2-like protein (SPATA2-like protein)	SPATA2L C16orf76	Homo sapiens (Human)	424				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q8IUW5	reviewed	RELL1_HUMAN	RELT-like protein 1	RELL1 PSEC0162	Homo sapiens (Human)	271	FUNCTION: Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}.		positive regulation of p38MAPK cascade [GO:1900745]	microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]		microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; positive regulation of p38MAPK cascade [GO:1900745]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16389068}; Single-pass type I membrane protein {ECO:0000269|PubMed:16389068}.
Q8IUX1	reviewed	T126B_HUMAN	Complex I assembly factor TMEM126B, mitochondrial (Transmembrane protein 126B)	TMEM126B HT007	Homo sapiens (Human)	230	FUNCTION: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I (PubMed:32320651, PubMed:27374773, PubMed:27374774). Participates in constructing the membrane arm of complex I (PubMed:24191001). {ECO:0000269|PubMed:24191001, ECO:0000269|PubMed:27374773, ECO:0000269|PubMed:27374774, ECO:0000269|PubMed:32320651}.		mitochondrial respiratory chain complex I assembly [GO:0032981]; response to food [GO:0032094]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; mitochondrial respiratory chain complex I assembly [GO:0032981]; response to food [GO:0032094]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:24191001}; Multi-pass membrane protein {ECO:0000269|PubMed:24191001}.
Q8IUX4	reviewed	ABC3F_HUMAN	DNA dC->dU-editing enzyme APOBEC-3F (EC 3.5.4.38) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F) (A3F)	APOBEC3F	Homo sapiens (Human)	373	FUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against viruse such as HIV-1 or HIV-2 (PubMed:15141007, PubMed:15152192, PubMed:23001005, PubMed:34774569). After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:15141007). The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:15141007, ECO:0000269|PubMed:15152192, ECO:0000269|PubMed:16378963, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19458006, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20219927, ECO:0000269|PubMed:20335265, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22807680, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:23001005, ECO:0000269|PubMed:23097438, ECO:0000269|PubMed:23152537, ECO:0000269|PubMed:34774569}.	MISCELLANEOUS: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.; MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site. {ECO:0000305}.	base conversion or substitution editing [GO:0016553]; clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral process [GO:0048525]; positive regulation of defense response to virus by host [GO:0002230]; retrotransposon silencing [GO:0010526]	apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]	cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]; cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; base conversion or substitution editing [GO:0016553]; clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral process [GO:0048525]; positive regulation of defense response to virus by host [GO:0002230]; retrotransposon silencing [GO:0010526]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, P-body.
Q8IUX7	reviewed	AEBP1_HUMAN	Adipocyte enhancer-binding protein 1 (AE-binding protein 1) (Aortic carboxypeptidase-like protein)	AEBP1 ACLP	Homo sapiens (Human)	1158	FUNCTION: [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix. {ECO:0000269|PubMed:29606302}.; FUNCTION: [Isoform 2]: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. {ECO:0000250|UniProtKB:Q640N1}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; peptide metabolic process [GO:0006518]; protein processing [GO:0016485]; regulation of collagen fibril organization [GO:1904026]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]	calmodulin binding [GO:0005516]; collagen binding [GO:0005518]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metallocarboxypeptidase activity [GO:0004181]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; calmodulin binding [GO:0005516]; collagen binding [GO:0005518]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metallocarboxypeptidase activity [GO:0004181]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptide metabolic process [GO:0006518]; protein processing [GO:0016485]; regulation of collagen fibril organization [GO:1904026]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000250|UniProtKB:Q640N1}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q640N1}. Nucleus {ECO:0000250|UniProtKB:Q640N1}.
Q8IUX8	reviewed	EGFL6_HUMAN	Epidermal growth factor-like protein 6 (EGF-like protein 6) (MAM and EGF domains-containing gene protein)	EGFL6 MAEG PP648 UNQ281/PRO320	Homo sapiens (Human)	553	FUNCTION: May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]	basement membrane [GO:0005604]; extracellular space [GO:0005615]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; integrin binding [GO:0005178]	basement membrane [GO:0005604]; extracellular space [GO:0005615]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}.
Q8IUY3	reviewed	GRM2A_HUMAN	GRAM domain-containing protein 2A	GRAMD2A GRAMD2	Homo sapiens (Human)	354	FUNCTION: Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE). {ECO:0000269|PubMed:29469807}.		endoplasmic reticulum-plasma membrane tethering [GO:0061817]; regulation of store-operated calcium entry [GO:2001256]	endoplasmic reticulum membrane [GO:0005789]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	endoplasmic reticulum membrane [GO:0005789]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; regulation of store-operated calcium entry [GO:2001256]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29469807}; Single-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:29469807}; Peripheral membrane protein {ECO:0000269|PubMed:29469807}. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Anchored at the ER, PM binding is mediated via GRAM domain and phosphatidylinositol lipid interaction. Localizes to distinct EPCS than GRAMD1A. {ECO:0000269|PubMed:29469807}.
Q8IUZ5	reviewed	AT2L2_HUMAN	5-phosphohydroxy-L-lysine phospho-lyase (EC 4.2.3.134) (Alanine--glyoxylate aminotransferase 2-like 2)	PHYKPL AGXT2L2 PP9286	Homo sapiens (Human)	450	FUNCTION: Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde. {ECO:0000269|PubMed:22241472}.			mitochondrial matrix [GO:0005759]	identical protein binding [GO:0042802]; lyase activity [GO:0016829]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]	mitochondrial matrix [GO:0005759]; identical protein binding [GO:0042802]; lyase activity [GO:0016829]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:22241472}.
Q8IV04	reviewed	TB10C_HUMAN	Carabin (TBC1 domain family member 10C)	TBC1D10C	Homo sapiens (Human)	446	FUNCTION: Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras. {ECO:0000269|PubMed:17230191}.		B cell activation [GO:0042113]; calcineurin-NFAT signaling cascade [GO:0033173]; ERK1 and ERK2 cascade [GO:0070371]; negative regulation of B cell activation [GO:0050869]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; ficolin-1-rich granule membrane [GO:0101003]; filopodium membrane [GO:0031527]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; ficolin-1-rich granule membrane [GO:0101003]; filopodium membrane [GO:0031527]; membrane [GO:0016020]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; B cell activation [GO:0042113]; calcineurin-NFAT signaling cascade [GO:0033173]; ERK1 and ERK2 cascade [GO:0070371]; negative regulation of B cell activation [GO:0050869]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; retrograde transport, endosome to Golgi [GO:0042147]	
Q8IV08	reviewed	PLD3_HUMAN	5'-3' exonuclease PLD3 (EC 3.1.16.1) (Choline phosphatase 3) (HindIII K4L homolog) (Hu-K4) (Phosphatidylcholine-hydrolyzing phospholipase D3) (Phospholipase D3) (PLD 3)	PLD3	Homo sapiens (Human)	490	FUNCTION: 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (PubMed:30312375). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation (PubMed:22428023). Plays a role in lysosomal homeostasis (PubMed:28128235). Involved in the regulation of endosomal protein sorting (PubMed:29368044). {ECO:0000250|UniProtKB:O35405, ECO:0000269|PubMed:22428023, ECO:0000269|PubMed:28128235, ECO:0000269|PubMed:29368044, ECO:0000269|PubMed:30312375}.		immune system process [GO:0002376]; inflammatory response [GO:0006954]; myotube differentiation [GO:0014902]; regulation of cytokine production involved in inflammatory response [GO:1900015]	early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]	phospholipase D activity [GO:0004630]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]	early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; phospholipase D activity [GO:0004630]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]; immune system process [GO:0002376]; inflammatory response [GO:0006954]; myotube differentiation [GO:0014902]; regulation of cytokine production involved in inflammatory response [GO:1900015]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}; Single-pass type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Lysosome lumen {ECO:0000269|PubMed:29386126, ECO:0000269|PubMed:30312375}. Early endosome membrane {ECO:0000269|PubMed:29386126}; Single-pass type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Late endosome membrane {ECO:0000269|PubMed:29386126}; Single-pass type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Golgi apparatus membrane {ECO:0000269|PubMed:29368044}; Single-pass type II membrane protein {ECO:0000269|PubMed:29368044}. Endosome membrane {ECO:0000269|PubMed:29368044}; Single-pass type II membrane protein {ECO:0000269|PubMed:29368044}. Note=Localizes to ER-associated vesicles in differentiating myotubes (PubMed:22428023). The soluble form in lysosome arises by proteolytic processing of the membrane-bound form (PubMed:29386126). Colocalizes with APP in endosomes (PubMed:29368044). {ECO:0000269|PubMed:22428023, ECO:0000269|PubMed:29368044, ECO:0000269|PubMed:29386126}.
Q8IV16	reviewed	HDBP1_HUMAN	Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) (GPI-anchored HDL-binding protein 1) (High density lipoprotein-binding protein 1)	GPIHBP1 HBP1	Homo sapiens (Human)	184	FUNCTION: Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (By similarity). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (By similarity). Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding (PubMed:27929370, PubMed:29899144). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:19304573, PubMed:21314738). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:17997385, PubMed:19304573). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (By similarity). {ECO:0000250|UniProtKB:Q9D1N2, ECO:0000269|PubMed:17997385, ECO:0000269|PubMed:19304573, ECO:0000269|PubMed:21314738, ECO:0000269|PubMed:27929370, ECO:0000269|PubMed:29899144}.		cholesterol homeostasis [GO:0042632]; intracellular protein transport [GO:0006886]; positive regulation of chylomicron remnant clearance [GO:0090321]; positive regulation of lipoprotein lipase activity [GO:0051006]; protein import [GO:0017038]; protein localization to cell surface [GO:0034394]; protein stabilization [GO:0050821]; response to heparin [GO:0071503]; transcytosis [GO:0045056]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; catalytic complex [GO:1902494]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	acetylcholine receptor inhibitor activity [GO:0030550]; chylomicron binding [GO:0035478]; lipase binding [GO:0035473]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; lipoprotein particle binding [GO:0071813]; protein transporter activity [GO:0140318]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; catalytic complex [GO:1902494]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; acetylcholine receptor inhibitor activity [GO:0030550]; chylomicron binding [GO:0035478]; lipase binding [GO:0035473]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; lipoprotein particle binding [GO:0071813]; protein transporter activity [GO:0140318]; cholesterol homeostasis [GO:0042632]; intracellular protein transport [GO:0006886]; positive regulation of chylomicron remnant clearance [GO:0090321]; positive regulation of lipoprotein lipase activity [GO:0051006]; protein import [GO:0017038]; protein localization to cell surface [GO:0034394]; protein stabilization [GO:0050821]; response to heparin [GO:0071503]; transcytosis [GO:0045056]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9D1N2}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9D1N2}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9D1N2}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9D1N2}. Cell membrane {ECO:0000269|PubMed:19304573}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9D1N2}.
Q8IV20	reviewed	LACC1_HUMAN	Purine nucleoside phosphorylase LACC1 (EC 2.4.2.1) (Adenosine deaminase LACC1) (EC 3.5.4.4) (Fatty acid metabolism-immunity nexus) (Guanosine phosphorylase LACC1) (Laccase domain-containing protein 1) (S-methyl-5'-thioadenosine phosphorylase LACC1) (EC 2.4.2.28)	LACC1 C13orf31 FAMIN	Homo sapiens (Human)	430	FUNCTION: Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine (PubMed:31978345). Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (PubMed:31978345). Also has adenosine deaminase activity (PubMed:31978345). Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed:31978345). Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface (PubMed:31978345). The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed:31978345). Participates in pattern recognition receptor (PRR)-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (PubMed:28593945, PubMed:31875558). Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (PubMed:31875558). Does not show laccase activity (PubMed:27959965, PubMed:31978345). {ECO:0000269|PubMed:27959965, ECO:0000269|PubMed:28593945, ECO:0000269|PubMed:31875558, ECO:0000269|PubMed:31978345}.		inflammatory response [GO:0006954]; innate immune response [GO:0045087]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cytokine production involved in immune response [GO:0002720]; regulation of cellular pH [GO:0030641]; regulation of inflammatory response [GO:0050727]; regulation of purine nucleotide metabolic process [GO:1900542]	endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; peroxisome [GO:0005777]	2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; copper ion binding [GO:0005507]; guanosine phosphorylase activity [GO:0047975]; purine-nucleoside phosphorylase activity [GO:0004731]; S-methyl-5-thioadenosine phosphorylase activity [GO:0017061]	endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; peroxisome [GO:0005777]; 2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; copper ion binding [GO:0005507]; guanosine phosphorylase activity [GO:0047975]; purine-nucleoside phosphorylase activity [GO:0004731]; S-methyl-5-thioadenosine phosphorylase activity [GO:0017061]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cytokine production involved in immune response [GO:0002720]; regulation of cellular pH [GO:0030641]; regulation of inflammatory response [GO:0050727]; regulation of purine nucleotide metabolic process [GO:1900542]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BZT9}. Nucleus {ECO:0000250|UniProtKB:Q8BZT9}. Endoplasmic reticulum {ECO:0000269|PubMed:31875558}. Peroxisome {ECO:0000269|PubMed:27478939, ECO:0000269|PubMed:27959965}. Note=Upon stimulation of the pattern-recognition receptor (PRR) NOD2, localizes to the endoplasmic reticulum. {ECO:0000269|PubMed:31875558}.
Q8IV31	reviewed	TM139_HUMAN	Transmembrane protein 139	TMEM139 UNQ1932/PRO4407	Homo sapiens (Human)	216	FUNCTION: May be involved in cellular trafficking of proteins such as SLC4A1. {ECO:0000305|PubMed:26049106}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8IV36	reviewed	HID1_HUMAN	Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog)	HID1 C17orf28 DMC1	Homo sapiens (Human)	788	FUNCTION: May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}.			cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytoplasmic side of Golgi membrane [GO:0098548]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; membrane [GO:0016020]		cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytoplasmic side of Golgi membrane [GO:0098548]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21337012}. Golgi apparatus membrane {ECO:0000269|PubMed:21337012}; Lipid-anchor {ECO:0000269|PubMed:21337012}. Note=Shuttles between the cytosol and the Golgi apparatus.
Q8IV45	reviewed	UN5CL_HUMAN	UNC5C-like protein (Protein unc-5 homolog C-like) (ZU5 and death domain-containing protein)	UNC5CL ZUD	Homo sapiens (Human)	518	FUNCTION: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets. {ECO:0000269|PubMed:14769797}.		positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330]	cytoplasm [GO:0005737]; membrane [GO:0016020]	netrin receptor activity [GO:0005042]; peptidase activity [GO:0008233]	cytoplasm [GO:0005737]; membrane [GO:0016020]; netrin receptor activity [GO:0005042]; peptidase activity [GO:0008233]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:14769797}.
Q8IV48	reviewed	ERI1_HUMAN	3'-5' exoribonuclease 1 (EC 3.1.-.-) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO)	ERI1 3'EXO THEX1	Homo sapiens (Human)	349	FUNCTION: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication (PubMed:14536070, PubMed:16912046, PubMed:17135487). A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates (PubMed:14536070, PubMed:16912046, PubMed:17135487). Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi) (PubMed:14961122). Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure (PubMed:14536070, PubMed:16912046). Able to bind other mRNAs (PubMed:14536070, PubMed:16912046). Required for 5.8S rRNA 3'-end processing (By similarity). Also binds to 5.8s ribosomal RNA (By similarity). Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs (PubMed:14536070, PubMed:17135487, PubMed:16912046). In vitro, does not have sequence specificity (PubMed:17135487). In vitro, has weak DNA exonuclease activity (PubMed:17135487). In vitro, shows biphasic kinetics such that there is rapid hydrolysis of the last three unpaired RNA nucleotides in the 39 flanking sequence followed by a much slower cleavage through the stem that occurs over a longer incubation period in the order of hours (PubMed:17135487). {ECO:0000250|UniProtKB:Q7TMF2, ECO:0000269|PubMed:14536070, ECO:0000269|PubMed:14961122, ECO:0000269|PubMed:16912046, ECO:0000269|PubMed:17135487}.		exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; regulatory ncRNA-mediated gene silencing [GO:0031047]; rRNA 3'-end processing [GO:0031125]	cytoplasm [GO:0005737]; histone pre-mRNA 3'end processing complex [GO:0071204]; nucleolus [GO:0005730]; nucleus [GO:0005634]	3'-5' exonuclease activity [GO:0008408]; 3'-5'-RNA exonuclease activity [GO:0000175]; histone pre-mRNA stem-loop binding [GO:0071207]; metal ion binding [GO:0046872]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]	cytoplasm [GO:0005737]; histone pre-mRNA 3'end processing complex [GO:0071204]; nucleolus [GO:0005730]; nucleus [GO:0005634]; 3'-5' exonuclease activity [GO:0008408]; 3'-5'-RNA exonuclease activity [GO:0000175]; histone pre-mRNA stem-loop binding [GO:0071207]; metal ion binding [GO:0046872]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; regulatory ncRNA-mediated gene silencing [GO:0031047]; rRNA 3'-end processing [GO:0031125]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16912046}. Nucleus {ECO:0000269|PubMed:16912046}. Nucleus, nucleolus {ECO:0000269|PubMed:16912046}.
Q8IV53	reviewed	DEN1C_HUMAN	DENN domain-containing protein 1C (Connecdenn 3) (Protein FAM31C)	DENND1C FAM31C	Homo sapiens (Human)	801	FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.		endocytic recycling [GO:0032456]; endocytosis [GO:0006897]	centrosome [GO:0005813]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phosphate binding [GO:1901981]	centrosome [GO:0005813]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phosphate binding [GO:1901981]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20154091}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:20154091}.
Q8IV61	reviewed	GRP3_HUMAN	Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1)	RASGRP3 GRP3 KIAA0846	Homo sapiens (Human)	690	FUNCTION: Guanine nucleotide exchange factor (GEF) for Ras and Rap1. {ECO:0000269|PubMed:10934204}.		MAPK cascade [GO:0000165]; Ras protein signal transduction [GO:0007265]; small GTPase mediated signal transduction [GO:0007264]	guanyl-nucleotide exchange factor complex [GO:0032045]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; small GTPase binding [GO:0031267]	guanyl-nucleotide exchange factor complex [GO:0032045]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; small GTPase binding [GO:0031267]; MAPK cascade [GO:0000165]; Ras protein signal transduction [GO:0007265]; small GTPase mediated signal transduction [GO:0007264]	
Q8IV63	reviewed	VRK3_HUMAN	Inactive serine/threonine-protein kinase VRK3 (Serine/threonine-protein pseudokinase VRK3) (Vaccinia-related kinase 3)	VRK3	Homo sapiens (Human)	474	FUNCTION: Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. {ECO:0000250, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:19141289}.		negative regulation of ERK1 and ERK2 cascade [GO:0070373]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519]	intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activity [GO:0004674]	intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activity [GO:0004674]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14645249}.
Q8IV76	reviewed	PASD1_HUMAN	Circadian clock protein PASD1 (Cancer/testis antigen 63) (CT63) (OX-TES-1) (PAS domain-containing protein 1)	PASD1	Homo sapiens (Human)	773	FUNCTION: Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801). {ECO:0000269|PubMed:25936801}.	MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.	circadian regulation of gene expression [GO:0032922]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	CLOCK-BMAL transcription complex [GO:1990513]; Cry-Per complex [GO:1990512]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; transcription regulator inhibitor activity [GO:0140416]	CLOCK-BMAL transcription complex [GO:1990513]; Cry-Per complex [GO:1990512]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; transcription regulator inhibitor activity [GO:0140416]; circadian regulation of gene expression [GO:0032922]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:25936801}. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). {ECO:0000269|PubMed:25936801}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:25936801}. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). {ECO:0000269|PubMed:25936801}.
Q8IV77	reviewed	CNGA4_HUMAN	Cyclic nucleotide-gated cation channel alpha-4 (Cyclic nucleotide-gated channel alpha-4) (CNG channel alpha-4) (CNG-4) (CNG4)	CNGA4	Homo sapiens (Human)	575	FUNCTION: Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). {ECO:0000250}.		monoatomic cation transmembrane transport [GO:0098655]; response to stimulus [GO:0050896]; sensory perception of smell [GO:0007608]	ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; plasma membrane [GO:0005886]	cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877]	ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; plasma membrane [GO:0005886]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877]; monoatomic cation transmembrane transport [GO:0098655]; response to stimulus [GO:0050896]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8IVB4	reviewed	SL9A9_HUMAN	Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9)	SLC9A9 NHE9 Nbla00118	Homo sapiens (Human)	645	FUNCTION: Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, e.g., endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters (PubMed:28130443, PubMed:15522866, PubMed:24065030). Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain (PubMed:28130443). Regulates synaptic transmission by regulating the luminal pH of axonal endosomes (By similarity). Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages (By similarity). Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH (By similarity). {ECO:0000250|UniProtKB:Q8BZ00, ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:24065030, ECO:0000269|PubMed:28130443, ECO:0000305|PubMed:15522866}.		defense response to bacterium [GO:0042742]; monoatomic ion transport [GO:0006811]; phagosome maturation [GO:0090382]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; late endosome membrane [GO:0031902]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]	potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; late endosome membrane [GO:0031902]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; defense response to bacterium [GO:0042742]; monoatomic ion transport [GO:0006811]; phagosome maturation [GO:0090382]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:15522866}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Early endosome membrane {ECO:0000269|PubMed:24065030, ECO:0000269|PubMed:28130443}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Recycling endosome membrane {ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:24065030, ECO:0000269|PubMed:28130443}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Cell membrane {ECO:0000250|UniProtKB:Q8BZ00}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q8BZ00}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Note=Localized to the plasma membrane in inner ear hair cell bundle. {ECO:0000250|UniProtKB:Q8BZ00}.
Q8IVD9	reviewed	NUDC3_HUMAN	NudC domain-containing protein 3	NUDCD3 KIAA1068	Homo sapiens (Human)	361			cilium assembly [GO:0060271]; protein folding [GO:0006457]; protein localization to pericentriolar material [GO:1905793]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; unfolded protein binding [GO:0051082]; cilium assembly [GO:0060271]; protein folding [GO:0006457]; protein localization to pericentriolar material [GO:1905793]	
Q8IVE3	reviewed	PKHH2_HUMAN	Pleckstrin homology domain-containing family H member 2	PLEKHH2 KIAA2028	Homo sapiens (Human)	1493	FUNCTION: In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.		negative regulation of actin filament depolymerization [GO:0030835]	cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	actin binding [GO:0003779]	cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; negative regulation of actin filament depolymerization [GO:0030835]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22832517}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22832517}. Cell membrane {ECO:0000269|PubMed:22832517}; Peripheral membrane protein {ECO:0000269|PubMed:22832517}; Cytoplasmic side {ECO:0000269|PubMed:22832517}. Cell projection, lamellipodium {ECO:0000269|PubMed:22832517}. Note=Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K.
Q8IVF2	reviewed	AHNK2_HUMAN	Protein AHNAK2	AHNAK2 C14orf78 KIAA2019	Homo sapiens (Human)	5795			regulation of RNA splicing [GO:0043484]	costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]		costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8IVF4	reviewed	DYH10_HUMAN	Dynein axonemal heavy chain 10 (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10)	DNAH10 KIAA2017	Homo sapiens (Human)	4471	FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (PubMed:34237282). Probable inner arm dynein heavy chain. {ECO:0000250, ECO:0000269|PubMed:34237282}.		cilium movement involved in cell motility [GO:0060294]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; cilium movement involved in cell motility [GO:0060294]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}.
Q8IVF5	reviewed	TIAM2_HUMAN	Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2)	TIAM2 KIAA2016 STEF	Homo sapiens (Human)	1701	FUNCTION: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}.		positive regulation of axonogenesis [GO:0050772]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perikaryon [GO:0043204]; synapse [GO:0045202]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perikaryon [GO:0043204]; synapse [GO:0045202]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; positive regulation of axonogenesis [GO:0050772]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q6ZPF3}. Perikaryon {ECO:0000250|UniProtKB:Q6ZPF3}.
Q8IVF7	reviewed	FMNL3_HUMAN	Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3)	FMNL3 FHOD3 FRL2 KIAA2014 WBP3	Homo sapiens (Human)	1028	FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. {ECO:0000250|UniProtKB:Q6NXC0, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22275430}.		actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; GTPase activating protein binding [GO:0032794]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; GTPase activating protein binding [GO:0032794]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21834987}. Cell membrane {ECO:0000269|PubMed:22275430}; Lipid-anchor {ECO:0000255}. Note=Enriched in lamellipodia.
Q8IVG5	reviewed	SAM9L_HUMAN	Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like)	SAMD9L C7orf6 DRIF2 KIAA2005 UEF	Homo sapiens (Human)	1584	FUNCTION: May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors. {ECO:0000250|UniProtKB:Q69Z37}.	MISCELLANEOUS: [Isoform 2]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.		cytoplasm [GO:0005737]; early endosome [GO:0005769]; mitochondrion [GO:0005739]		cytoplasm [GO:0005737]; early endosome [GO:0005769]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q69Z37}. Mitochondrion {ECO:0000269|PubMed:35310830}.
Q8IVG9	reviewed	HUNIN_HUMAN	Humanin (Humanin mitochondrial) (HNM)	MT-RNR2 HN	Homo sapiens (Human)	24	FUNCTION: Plays a role as a neuroprotective factor (PubMed:11371646, PubMed:11717357, PubMed:12860203, PubMed:19386761, PubMed:12787071, PubMed:12154011). Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease (PubMed:11371646, PubMed:11717357, PubMed:12860203, PubMed:19386761, PubMed:12787071, PubMed:12154011). Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR (PubMed:19386761). Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2 (PubMed:15465011). Inhibits amyloid-beta protein 40 fibril formation (PubMed:27349871). Also inhibits amyloid-beta protein 42 fibril formation (PubMed:28282805). Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria (PubMed:12732850, PubMed:26990160). Also suppresses apoptosis by binding to BID and inhibiting the interaction of BID with BAX and BAK which prevents oligomerization of BAX and BAK and suppresses release of apoptogenic proteins from mitochondria (PubMed:15661737). Forms fibers with BAX and also with BID, inducing BAX and BID conformational changes and sequestering them into the fibers which prevents their activation (PubMed:31690630, PubMed:33106313). Can also suppress apoptosis by interacting with BIM isoform BimEL, inhibiting BimEL-induced activation of BAX, blocking oligomerization of BAX and BAK, and preventing release of apoptogenic proteins from mitochondria (PubMed:15661735). Plays a role in up-regulation of anti-apoptotic protein BIRC6/APOLLON, leading to inhibition of neuronal cell death (PubMed:25138702). Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death (PubMed:14561895, PubMed:26216267). Competes with importin KPNB1 for binding to IGFBP3 which is likely to block IGFBP3 nuclear import (PubMed:26216267). Induces chemotaxis of mononuclear phagocytes via FPR2/FPRL1 (PubMed:15153530). Reduces aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPR2 to APP (PubMed:15153530). Protects retinal pigment epithelium (RPE) cells against oxidative stress-induced and endoplasmic reticulum (ER) stress-induced apoptosis (PubMed:26990160, PubMed:27783653). Promotes mitochondrial biogenesis in RPE cells following oxidative stress and promotes STAT3 phosphorylation which leads to inhibition of CASP3 release (PubMed:26990160). Also reduces CASP4 levels in RPE cells, suppresses ER stress-induced mitochondrial superoxide production and plays a role in up-regulation of mitochondrial glutathione (PubMed:27783653). Reduces testicular hormone deprivation-induced apoptosis of germ cells at the nonandrogen-sensitive stages of the seminiferous epithelium cycle (PubMed:19952275). Protects endothelial cells against free fatty acid-induced inflammation by suppressing oxidative stress, reducing expression of TXNIP and inhibiting activation of the NLRP3 inflammasome which inhibits expression of pro-inflammatory cytokines IL1B and IL18 (PubMed:32923762). Protects against high glucose-induced endothelial cell dysfunction by mediating activation of ERK5 which leads to increased expression of transcription factor KLF2 and prevents monocyte adhesion to endothelial cells (PubMed:30029058). Inhibits the inflammatory response in astrocytes (PubMed:23277413). Increases the expression of PPARGC1A/PGC1A in pancreatic beta cells which promotes mitochondrial biogenesis (PubMed:29432738). Increases insulin sensitivity (PubMed:19623253). {ECO:0000269|PubMed:11371646, ECO:0000269|PubMed:11717357, ECO:0000269|PubMed:12154011, ECO:0000269|PubMed:12732850, ECO:0000269|PubMed:12787071, ECO:0000269|PubMed:12860203, ECO:0000269|PubMed:14561895, ECO:0000269|PubMed:15153530, ECO:0000269|PubMed:15465011, ECO:0000269|PubMed:15661735, ECO:0000269|PubMed:15661737, ECO:0000269|PubMed:19386761, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:23277413, ECO:0000269|PubMed:25138702, ECO:0000269|PubMed:26216267, ECO:0000269|PubMed:26990160, ECO:0000269|PubMed:27349871, ECO:0000269|PubMed:27783653, ECO:0000269|PubMed:28282805, ECO:0000269|PubMed:29432738, ECO:0000269|PubMed:30029058, ECO:0000269|PubMed:31690630, ECO:0000269|PubMed:32923762, ECO:0000269|PubMed:33106313}.		apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; cellular response to amyloid-beta [GO:1904646]; intracellular iron ion homeostasis [GO:0006879]; leukocyte chemotaxis [GO:0030595]; mitochondrion organization [GO:0007005]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of apoptotic process [GO:0043066]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-18 production [GO:0032701]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of response to oxidative stress [GO:1902883]; supramolecular fiber organization [GO:0097435]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]	G protein-coupled receptor binding [GO:0001664]; identical protein binding [GO:0042802]; protein self-association [GO:0043621]; receptor antagonist activity [GO:0048019]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; G protein-coupled receptor binding [GO:0001664]; identical protein binding [GO:0042802]; protein self-association [GO:0043621]; receptor antagonist activity [GO:0048019]; signaling receptor binding [GO:0005102]; apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; cellular response to amyloid-beta [GO:1904646]; intracellular iron ion homeostasis [GO:0006879]; leukocyte chemotaxis [GO:0030595]; mitochondrion organization [GO:0007005]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of apoptotic process [GO:0043066]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-18 production [GO:0032701]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of response to oxidative stress [GO:1902883]; supramolecular fiber organization [GO:0097435]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11371646, ECO:0000269|PubMed:12860203, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:26990160}. Cytoplasm {ECO:0000269|PubMed:11371646, ECO:0000269|PubMed:12670303, ECO:0000269|PubMed:15661737, ECO:0000269|PubMed:20542501, ECO:0000269|PubMed:26990160}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:20542501, ECO:0000269|PubMed:30920769}. Nucleus {ECO:0000269|PubMed:20542501}. Mitochondrion {ECO:0000269|PubMed:20542501, ECO:0000269|PubMed:26990160}. Note=Localizes to the sperm flagellum where it is highly concentrated in the midpiece (PubMed:20542501, PubMed:30920769). Detected in the cytoplasm and nucleus of spermatocytes and spermatids (PubMed:20542501). Also detected in sperm mitochondria (PubMed:20542501). In retinal pigment epithelium cells, detected in cytoplasm and mitochondria (PubMed:26990160). {ECO:0000269|PubMed:20542501, ECO:0000269|PubMed:26990160, ECO:0000269|PubMed:30920769}.
Q8IVH2	reviewed	FOXP4_HUMAN	Forkhead box protein P4 (Fork head-related protein-like A)	FOXP4 FKHLA	Homo sapiens (Human)	680	FUNCTION: Transcriptional repressor that represses lung-specific expression. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Q8IVH4	reviewed	MMAA_HUMAN	Methylmalonic aciduria type A protein, mitochondrial (EC 3.6.-.-)	MMAA	Homo sapiens (Human)	418	FUNCTION: GTPase, binds and hydrolyzes GTP (PubMed:28497574, PubMed:20876572, PubMed:21138732, PubMed:28943303). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (PubMed:28497574, PubMed:20876572). Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (PubMed:28497574, PubMed:20876572). Plays a dual role as both a protectase and a reactivase for MMUT (PubMed:21138732, PubMed:28943303). Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) (PubMed:21138732, PubMed:28943303). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP (PubMed:21138732, PubMed:28943303). {ECO:0000269|PubMed:20876572, ECO:0000269|PubMed:21138732, ECO:0000269|PubMed:28497574, ECO:0000269|PubMed:28943303}.		cobalamin metabolic process [GO:0009235]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; cobalamin metabolic process [GO:0009235]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:28943303, ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:28943303}.
Q8IVH8	reviewed	M4K3_HUMAN	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)	MAP4K3 RAB8IPL1	Homo sapiens (Human)	894	FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9275185}.		intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; protein phosphorylation [GO:0006468]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; protein phosphorylation [GO:0006468]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]	
Q8IVI9	reviewed	NOSTN_HUMAN	Nostrin (BM247 homolog) (Nitric oxide synthase traffic inducer) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer)	NOSTRIN	Homo sapiens (Human)	506	FUNCTION: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16234328, ECO:0000269|PubMed:16807357}.	MISCELLANEOUS: [Isoform 3]: May negatively regulate transcription of the NOSTRIN gene. {ECO:0000269|PubMed:18980613}.	actin filament organization [GO:0007015]; cell migration [GO:0016477]; endocytosis [GO:0006897]; negative regulation of DNA-templated transcription [GO:0045892]; signal transduction [GO:0007165]	cytoskeleton [GO:0005856]; endocytic vesicle membrane [GO:0030666]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]	cytoskeleton [GO:0005856]; endocytic vesicle membrane [GO:0030666]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; endocytosis [GO:0006897]; negative regulation of DNA-templated transcription [GO:0045892]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16376344}; Peripheral membrane protein {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16376344}; Cytoplasmic side {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16376344}. Cytoplasmic vesicle {ECO:0000269|PubMed:12446846}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16234328, ECO:0000269|PubMed:16376344}. Note=Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:18980613}.
Q8IVJ1	reviewed	S41A1_HUMAN	Solute carrier family 41 member 1	SLC41A1	Homo sapiens (Human)	513	FUNCTION: Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed:22031603, PubMed:23661805, PubMed:18367447, PubMed:23976986). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (PubMed:22031603, PubMed:23661805). Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). {ECO:0000250|UniProtKB:Q8BJA2, ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:22031603, ECO:0000269|PubMed:23661805, ECO:0000269|PubMed:23976986, ECO:0000269|PubMed:27074515}.		cellular response to magnesium ion [GO:0071286]; intracellular magnesium ion homeostasis [GO:0010961]; magnesium ion transmembrane transport [GO:1903830]; magnesium ion transport [GO:0015693]; metal ion transport [GO:0030001]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	inorganic cation transmembrane transporter activity [GO:0022890]; magnesium ion transmembrane transporter activity [GO:0015095]; magnesium:sodium antiporter activity [GO:0061768]; transmembrane transporter activity [GO:0022857]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; inorganic cation transmembrane transporter activity [GO:0022890]; magnesium ion transmembrane transporter activity [GO:0015095]; magnesium:sodium antiporter activity [GO:0061768]; transmembrane transporter activity [GO:0022857]; cellular response to magnesium ion [GO:0071286]; intracellular magnesium ion homeostasis [GO:0010961]; magnesium ion transmembrane transport [GO:1903830]; magnesium ion transport [GO:0015693]; metal ion transport [GO:0030001]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:23976986}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:23661805}; Multi-pass membrane protein {ECO:0000255}.
Q8IVL0	reviewed	NAV3_HUMAN	Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3)	NAV3 KIAA0938 POMFIL1 STEERIN3	Homo sapiens (Human)	2385	FUNCTION: Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}.		negative regulation of cell migration [GO:0030336]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of microtubule depolymerization [GO:0007026]; neurogenesis [GO:0022008]; positive regulation of microtubule polymerization [GO:0031116]	nuclear outer membrane [GO:0005640]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]	nuclear outer membrane [GO:0005640]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; negative regulation of cell migration [GO:0030336]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of microtubule depolymerization [GO:0007026]; neurogenesis [GO:0022008]; positive regulation of microtubule polymerization [GO:0031116]	SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000250|UniProtKB:Q80TN7}.
Q8IVL1	reviewed	NAV2_HUMAN	Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2)	NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2	Homo sapiens (Human)	2488	FUNCTION: Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.		glossopharyngeal nerve development [GO:0021563]; locomotory behavior [GO:0007626]; neurogenesis [GO:0022008]; optic nerve development [GO:0021554]; regulation of systemic arterial blood pressure by baroreceptor feedback [GO:0003025]; sensory perception of smell [GO:0007608]; sensory perception of sound [GO:0007605]; vagus nerve development [GO:0021564]	interstitial matrix [GO:0005614]; nucleoplasm [GO:0005654]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; heparin binding [GO:0008201]	interstitial matrix [GO:0005614]; nucleoplasm [GO:0005654]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; heparin binding [GO:0008201]; glossopharyngeal nerve development [GO:0021563]; locomotory behavior [GO:0007626]; neurogenesis [GO:0022008]; optic nerve development [GO:0021554]; regulation of systemic arterial blood pressure by baroreceptor feedback [GO:0003025]; sensory perception of smell [GO:0007608]; sensory perception of sound [GO:0007605]; vagus nerve development [GO:0021564]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12214280}.
Q8IVL5	reviewed	P3H2_HUMAN	Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4)	P3H2 LEPREL1 MLAT4	Homo sapiens (Human)	708	FUNCTION: Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:18487197). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1 (PubMed:18487197). Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline (PubMed:18487197). Has no activity on substrates that lack 4-hydroxyproline in the third position (PubMed:18487197). {ECO:0000250|UniProtKB:Q8CG71, ECO:0000269|PubMed:18487197}.		collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; peptidyl-proline hydroxylation [GO:0019511]	basement membrane [GO:0005604]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum [GO:0016529]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797]	basement membrane [GO:0005604]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum [GO:0016529]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797]; collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; peptidyl-proline hydroxylation [GO:0019511]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:15063763}. Sarcoplasmic reticulum {ECO:0000305|PubMed:15063763}. Golgi apparatus {ECO:0000269|PubMed:15063763}.
Q8IVL6	reviewed	P3H3_HUMAN	Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B)	P3H3 LEPREL2	Homo sapiens (Human)	736	FUNCTION: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases. {ECO:0000250|UniProtKB:Q8CG70}.		collagen biosynthetic process [GO:0032964]; collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; peptidyl-lysine hydroxylation [GO:0017185]	catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797]	catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797]; collagen biosynthetic process [GO:0032964]; collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; peptidyl-lysine hydroxylation [GO:0017185]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q8IVL8	reviewed	CBPO_HUMAN	Carboxypeptidase O (CPO) (EC 3.4.17.-)	CPO	Homo sapiens (Human)	374	FUNCTION: Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues. {ECO:0000269|PubMed:21921028}.		proteolysis [GO:0006508]	apical plasma membrane [GO:0016324]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:21921028}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:21921028}.
Q8IVM0	reviewed	CCD50_HUMAN	Coiled-coil domain-containing protein 50 (Protein Ymer)	CCDC50 C3orf6	Homo sapiens (Human)	306	FUNCTION: Involved in EGFR signaling. {ECO:0000269|PubMed:15314609}.	MISCELLANEOUS: Found in a critical region of hereditary spastic paraplegia (HSP) SPG14 locus. No causative CCDC50 mutations were found in HSP families.; MISCELLANEOUS: [Isoform 1]: Major isoform.	sensory perception of sound [GO:0007605]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin protein ligase binding [GO:0031625]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with microtubules of the cytoskeleton and mitotic apparatus. {ECO:0000250}.
Q8IVM8	reviewed	S22A9_HUMAN	Organic anion transporter 7 (OAT7) (Organic anion/short-chain fatty acid exchanger) (Solute carrier family 22 member 9)	SLC22A9 hOAT4 OAT7 UST3	Homo sapiens (Human)	553	FUNCTION: Sodium-independent organic anion transporter, exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) (PubMed:17393504, PubMed:26239079, PubMed:28945155). Can transport the statin pravastatin and may contribute to its disposition into the hepatocytes when the function of OATPs is compromised (PubMed:26239079). It is specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate (propanoate), butyrate (butanoate) and valerate (pentanoate) (PubMed:17393504). May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs, in particular butanoate, at the sinusoidal membrane of hepatocytes (PubMed:17393504). {ECO:0000269|PubMed:17393504, ECO:0000269|PubMed:26239079, ECO:0000269|PubMed:28945155}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	hormone transport [GO:0009914]; organic anion transport [GO:0015711]; short-chain fatty acid transmembrane transport [GO:0015913]; sodium-independent organic anion transport [GO:0043252]	basolateral plasma membrane [GO:0016323]	organic anion transmembrane transporter activity [GO:0008514]; short-chain fatty acid transmembrane transporter activity [GO:0015636]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]	basolateral plasma membrane [GO:0016323]; organic anion transmembrane transporter activity [GO:0008514]; short-chain fatty acid transmembrane transporter activity [GO:0015636]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; hormone transport [GO:0009914]; organic anion transport [GO:0015711]; short-chain fatty acid transmembrane transport [GO:0015913]; sodium-independent organic anion transport [GO:0043252]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:17393504}; Multi-pass membrane protein {ECO:0000269|PubMed:17393504}. Note=Enriched at the sinusoidal part of the plasma membrane.
Q8IVP5	reviewed	FUND1_HUMAN	FUN14 domain-containing protein 1	FUNDC1	Homo sapiens (Human)	155	FUNCTION: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. {ECO:0000269|PubMed:22267086}.		autophagy of mitochondrion [GO:0000422]; response to hypoxia [GO:0001666]; response to organonitrogen compound [GO:0010243]	mitochondrial outer membrane [GO:0005741]		mitochondrial outer membrane [GO:0005741]; autophagy of mitochondrion [GO:0000422]; response to hypoxia [GO:0001666]; response to organonitrogen compound [GO:0010243]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:22267086}; Multi-pass membrane protein {ECO:0000269|PubMed:22267086}.
Q8IVP9	reviewed	ZN547_HUMAN	Zinc finger protein 547	ZNF547	Homo sapiens (Human)	402	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IVQ6	reviewed	ZDH21_HUMAN	Palmitoyltransferase ZDHHC21 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 21) (DHHC-21) (Zinc finger DHHC domain-containing protein 21)	ZDHHC21	Homo sapiens (Human)	265	FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:22031296). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane (PubMed:22031296). This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (PubMed:22031296). Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK (By similarity). {ECO:0000250|UniProtKB:Q9D270, ECO:0000269|PubMed:22031296}.		adrenergic receptor signaling pathway [GO:0071875]; hair follicle development [GO:0001942]; nitric oxide metabolic process [GO:0046209]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of leukocyte adhesion to arterial endothelial cell [GO:1904997]; regulation of vascular associated smooth muscle contraction [GO:0003056]; sebaceous gland development [GO:0048733]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; adrenergic receptor signaling pathway [GO:0071875]; hair follicle development [GO:0001942]; nitric oxide metabolic process [GO:0046209]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of leukocyte adhesion to arterial endothelial cell [GO:1904997]; regulation of vascular associated smooth muscle contraction [GO:0003056]; sebaceous gland development [GO:0048733]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:22031296}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q9D270}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:16647879}; Multi-pass membrane protein {ECO:0000255}.
Q8IVS2	reviewed	FABD_HUMAN	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyl CoA:ACP acyltransferase) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase)	MCAT MT	Homo sapiens (Human)	390	FUNCTION: Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria. {ECO:0000269|PubMed:12882974}.		fatty acid beta-oxidation [GO:0006635]; fatty acid biosynthetic process [GO:0006633]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	[acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; RNA binding [GO:0003723]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; RNA binding [GO:0003723]; fatty acid beta-oxidation [GO:0006635]; fatty acid biosynthetic process [GO:0006633]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12882974}.
Q8IVS8	reviewed	GLCTK_HUMAN	Glycerate kinase (EC 2.7.1.31) (HBeAg-binding protein 4)	GLYCTK HBEBP4 LP5910	Homo sapiens (Human)	523			fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; glycerate kinase activity [GO:0008887]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; glycerate kinase activity [GO:0008887]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16753811}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Mitochondrion {ECO:0000269|PubMed:16753811}.
Q8IVT2	reviewed	MISP_HUMAN	Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein)	MISP C19orf21	Homo sapiens (Human)	679	FUNCTION: Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.		cell division [GO:0051301]; cell migration [GO:0016477]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; mitotic spindle assembly [GO:0090307]; organelle localization [GO:0051640]; regulation of protein localization to cell cortex [GO:1904776]	actin filament [GO:0005884]; cell cortex [GO:0005938]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; spindle pole centrosome [GO:0031616]	actin filament binding [GO:0051015]	actin filament [GO:0005884]; cell cortex [GO:0005938]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; spindle pole centrosome [GO:0031616]; actin filament binding [GO:0051015]; cell division [GO:0051301]; cell migration [GO:0016477]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; mitotic spindle assembly [GO:0090307]; organelle localization [GO:0051640]; regulation of protein localization to cell cortex [GO:1904776]	SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis.
Q8IVT5	reviewed	KSR1_HUMAN	Kinase suppressor of Ras 1 (EC 2.7.11.1)	KSR1 KSR	Homo sapiens (Human)	923	FUNCTION: Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}.		cAMP-mediated signaling [GO:0019933]; phosphorylation [GO:0016310]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of cell population proliferation [GO:0042127]; regulation of MAP kinase activity [GO:0043405]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]	14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cAMP-mediated signaling [GO:0019933]; phosphorylation [GO:0016310]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of cell population proliferation [GO:0042127]; regulation of MAP kinase activity [GO:0043405]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20679487}. Membrane {ECO:0000269|PubMed:20679487}; Peripheral membrane protein {ECO:0000269|PubMed:20679487}. Cell membrane {ECO:0000250|UniProtKB:Q61097}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q61097}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q61097}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20679487}. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. {ECO:0000305|PubMed:12007434}.
Q8IVU3	reviewed	HERC6_HUMAN	Probable E3 ubiquitin-protein ligase HERC6 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 6) (HECT-type E3 ubiquitin transferase HERC6)	HERC6	Homo sapiens (Human)	1022	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: Major transcript.; MISCELLANEOUS: [Isoform 2]: Minor transcript. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Minor transcript. {ECO:0000305}.	hematopoietic progenitor cell differentiation [GO:0002244]; protein ubiquitination [GO:0016567]; response to bacterium [GO:0009617]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ubiquitin protein ligase activity [GO:0061630]; hematopoietic progenitor cell differentiation [GO:0002244]; protein ubiquitination [GO:0016567]; response to bacterium [GO:0009617]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15676274}.
Q8IVV7	reviewed	GID4_HUMAN	Glucose-induced degradation protein 4 homolog (Vacuolar import and degradation protein 24 homolog)	GID4 C17orf39 VID24	Homo sapiens (Human)	300	FUNCTION: Substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (Probable) (PubMed:29911972). Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly-Leu-Trp (PubMed:29632410). Binds peptides with an N-terminal sequence of the type Pro-[Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind peptides with an acetylated N-terminal Pro residue (PubMed:29632410). {ECO:0000269|PubMed:29632410, ECO:0000269|PubMed:29911972, ECO:0000305}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin ligase complex [GO:0000151]	ubiquitin protein ligase activity [GO:0061630]	ubiquitin ligase complex [GO:0000151]; ubiquitin protein ligase activity [GO:0061630]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	
Q8IVW4	reviewed	CDKL3_HUMAN	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine-protein kinase NKIAMRE)	CDKL3 NKIAMRE	Homo sapiens (Human)	592			dendrite extension [GO:0097484]; negative regulation of axon extension [GO:0030517]; phosphorylation [GO:0016310]; positive regulation of dendrite morphogenesis [GO:0050775]; protein modification process [GO:0036211]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; dendrite extension [GO:0097484]; negative regulation of axon extension [GO:0030517]; phosphorylation [GO:0016310]; positive regulation of dendrite morphogenesis [GO:0050775]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8IVW6	reviewed	ARI3B_HUMAN	AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein)	ARID3B BDP DRIL2	Homo sapiens (Human)	561	FUNCTION: Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. {ECO:0000269|PubMed:16951138, ECO:0000269|PubMed:17400556}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:10446990, ECO:0000269|PubMed:17400556}.
Q8IVW8	reviewed	SPNS2_HUMAN	Sphingosine-1-phosphate transporter SPNS2 (Protein spinster homolog 2)	SPNS2	Homo sapiens (Human)	549	FUNCTION: Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate in the lymph, thereby playing a role in lymphocyte trafficking (PubMed:19074308, PubMed:23180825, PubMed:21084291). S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system (PubMed:19074308, PubMed:23180825). Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking (PubMed:19074308, PubMed:23180825). Required for the egress of T-cells from lymph nodes during an immune response by mediating S1P secretion, which generates a gradient that enables activated T-cells to access lymph (By similarity). Also required for the egress of immature B-cells from the bone marrow (By similarity). In contrast, not involved in S1P release from red blood cells (By similarity). Involved in auditory function (PubMed:30973865). S1P release in the inner ear is required for maintenance of the endocochlear potential in the cochlea (By similarity). In addition to export, also able to mediate S1P import (By similarity). {ECO:0000250|UniProtKB:Q91VM4, ECO:0000269|PubMed:19074308, ECO:0000269|PubMed:21084291, ECO:0000269|PubMed:23180825, ECO:0000269|PubMed:30973865}.		B cell homeostasis [GO:0001782]; bone development [GO:0060348]; lipid transport [GO:0006869]; lymph node development [GO:0048535]; lymphocyte migration [GO:0072676]; regulation of eye pigmentation [GO:0048073]; regulation of humoral immune response [GO:0002920]; regulation of T cell migration [GO:2000404]; sensory perception of sound [GO:0007605]; sphingolipid biosynthetic process [GO:0030148]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; T cell homeostasis [GO:0043029]	endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]	sphingolipid transporter activity [GO:0046624]; transmembrane transporter activity [GO:0022857]	endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sphingolipid transporter activity [GO:0046624]; transmembrane transporter activity [GO:0022857]; B cell homeostasis [GO:0001782]; bone development [GO:0060348]; lipid transport [GO:0006869]; lymph node development [GO:0048535]; lymphocyte migration [GO:0072676]; regulation of eye pigmentation [GO:0048073]; regulation of humoral immune response [GO:0002920]; regulation of T cell migration [GO:2000404]; sensory perception of sound [GO:0007605]; sphingolipid biosynthetic process [GO:0030148]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; T cell homeostasis [GO:0043029]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A2SWM2}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:A2SWM2}; Multi-pass membrane protein {ECO:0000255}.
Q8IW00	reviewed	VSTM4_HUMAN	V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv]	VSTM4 C10orf72	Homo sapiens (Human)	320	FUNCTION: Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors. {ECO:0000250|UniProtKB:T1NXB5}.		endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; retina blood vessel maintenance [GO:0097601]; retina vasculature development in camera-type eye [GO:0061298]; sprouting angiogenesis [GO:0002040]; vasodilation [GO:0042311]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; retina blood vessel maintenance [GO:0097601]; retina vasculature development in camera-type eye [GO:0061298]; sprouting angiogenesis [GO:0002040]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: [Peptide Lv]: Secreted {ECO:0000250|UniProtKB:T1NXB5}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8IW19	reviewed	APLF_HUMAN	Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1)	APLF C2orf13 PALF XIP1	Homo sapiens (Human)	511	FUNCTION: Histone chaperone involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150, PubMed:21211721, PubMed:21211722, PubMed:30104678, PubMed:29905837). Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17353262, PubMed:17396150, PubMed:21211721, PubMed:30104678). Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 (PubMed:21211722, PubMed:30104678, PubMed:29905837). Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro (PubMed:17353262, PubMed:17396150). Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (PubMed:17353262, PubMed:17396150). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721, PubMed:23689425). Also acts as a negative regulator of cell pluripotency by promoting histone exchange (By similarity). Required for the embryo implantation during the epithelial to mesenchymal transition in females (By similarity). {ECO:0000250|UniProtKB:Q9D842, ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:21211721, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:23689425, ECO:0000269|PubMed:29905837, ECO:0000269|PubMed:30104678}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; embryo implantation [GO:0007566]; positive regulation of DNA ligation [GO:0051106]; protein localization to chromatin [GO:0071168]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of isotype switching [GO:0045191]; single strand break repair [GO:0000012]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]	3'-5' exonuclease activity [GO:0008408]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; DNA endonuclease activity [GO:0004520]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; poly-ADP-D-ribose binding [GO:0072572]; protein folding chaperone [GO:0044183]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; 3'-5' exonuclease activity [GO:0008408]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; DNA endonuclease activity [GO:0004520]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; poly-ADP-D-ribose binding [GO:0072572]; protein folding chaperone [GO:0044183]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; embryo implantation [GO:0007566]; positive regulation of DNA ligation [GO:0051106]; protein localization to chromatin [GO:0071168]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of isotype switching [GO:0045191]; single strand break repair [GO:0000012]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:17507382, ECO:0000269|PubMed:23689425}. Chromosome {ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:18474613, ECO:0000269|PubMed:21211721, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:23689425, ECO:0000269|PubMed:27063109}. Cytoplasm, cytosol {ECO:0000269|PubMed:17353262}. Note=Localizes to DNA damage sites (PubMed:18474613, PubMed:18172500, PubMed:21211721, PubMed:21211722, PubMed:23689425). Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers (PubMed:18172500). {ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:18474613, ECO:0000269|PubMed:21211721, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:23689425}.
Q8IW35	reviewed	CEP97_HUMAN	Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2)	CEP97 LRRIQ2	Homo sapiens (Human)	865	FUNCTION: Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}.	MISCELLANEOUS: [Isoform 2]: Sequence incomplete. {ECO:0000305}.	cell projection organization [GO:0030030]; negative regulation of cilium assembly [GO:1902018]; regulation of mitotic spindle assembly [GO:1901673]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]	calmodulin binding [GO:0005516]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; calmodulin binding [GO:0005516]; cell projection organization [GO:0030030]; negative regulation of cilium assembly [GO:1902018]; regulation of mitotic spindle assembly [GO:1901673]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30375385}. Note=Recruited at the distal end of the mother centriole by MPHOSPH9. {ECO:0000269|PubMed:30375385}.
Q8IW40	reviewed	CC103_HUMAN	Coiled-coil domain-containing protein 103	CCDC103	Homo sapiens (Human)	242	FUNCTION: Dynein-attachment factor required for cilia motility. {ECO:0000269|PubMed:22581229}.		axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158]	axoneme [GO:0005930]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157]	protein homodimerization activity [GO:0042803]	axoneme [GO:0005930]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157]; protein homodimerization activity [GO:0042803]; axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000250}.
Q8IW41	reviewed	MAPK5_HUMAN	MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK)	MAPKAPK5 PRAK	Homo sapiens (Human)	473	FUNCTION: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}.		cellular senescence [GO:0090398]; negative regulation of TOR signaling [GO:0032007]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; Ras protein signal transduction [GO:0007265]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of translation [GO:0006417]; signal transduction [GO:0007165]; stress-induced premature senescence [GO:0090400]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; septin cytoskeleton [GO:0032156]	ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase binding [GO:0051019]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; septin cytoskeleton [GO:0032156]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase binding [GO:0051019]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cellular senescence [GO:0090398]; negative regulation of TOR signaling [GO:0032007]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; Ras protein signal transduction [GO:0007265]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of translation [GO:0006417]; signal transduction [GO:0007165]; stress-induced premature senescence [GO:0090400]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.
Q8IW45	reviewed	NNRD_HUMAN	ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase)	NAXD CARKD	Homo sapiens (Human)	347	FUNCTION: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. {ECO:0000255|HAMAP-Rule:MF_03157, ECO:0000269|PubMed:30576410}.	MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted. {ECO:0000255|HAMAP-Rule:MF_03157}.	metabolite repair [GO:0110051]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]	mitochondrial matrix [GO:0005759]	ATP binding [GO:0005524]; ATP-dependent NAD(P)H-hydrate dehydratase activity [GO:0047453]	mitochondrial matrix [GO:0005759]; ATP binding [GO:0005524]; ATP-dependent NAD(P)H-hydrate dehydratase activity [GO:0047453]; metabolite repair [GO:0110051]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03157}.
Q8IW52	reviewed	SLIK4_HUMAN	SLIT and NTRK-like protein 4	SLITRK4	Homo sapiens (Human)	837	FUNCTION: It is involved in synaptogenesis and promotes synapse differentiation (PubMed:27812321). Suppresses neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q810B8, ECO:0000269|PubMed:27812321}.		axonogenesis [GO:0007409]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; regulation of synapse organization [GO:0050807]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]		glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; axonogenesis [GO:0007409]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; regulation of synapse organization [GO:0050807]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:27812321}.
Q8IW75	reviewed	SPA12_HUMAN	Serpin A12 (OL-64) (Visceral adipose tissue-derived serine protease inhibitor) (Vaspin) (Visceral adipose-specific serpin)	SERPINA12	Homo sapiens (Human)	414	FUNCTION: Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. {ECO:0000269|PubMed:16030142, ECO:0000269|PubMed:23370777, ECO:0000269|PubMed:26199422, ECO:0000269|PubMed:28668641}.		gluconeogenesis [GO:0006094]; lipid biosynthetic process [GO:0008610]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of lipid biosynthetic process [GO:0051055]; positive regulation of insulin receptor signaling pathway [GO:0046628]; regulation of cholesterol metabolic process [GO:0090181]; regulation of triglyceride metabolic process [GO:0090207]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	molecular function inhibitor activity [GO:0140678]; serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; molecular function inhibitor activity [GO:0140678]; serine-type endopeptidase inhibitor activity [GO:0004867]; gluconeogenesis [GO:0006094]; lipid biosynthetic process [GO:0008610]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of lipid biosynthetic process [GO:0051055]; positive regulation of insulin receptor signaling pathway [GO:0046628]; regulation of cholesterol metabolic process [GO:0090181]; regulation of triglyceride metabolic process [GO:0090207]	SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:28668641}.
Q8IWA0	reviewed	WDR75_HUMAN	WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog)	WDR75 UTP17	Homo sapiens (Human)	830	FUNCTION: Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}.		positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:22916032, ECO:0000269|PubMed:34516797}.
Q8IWA4	reviewed	MFN1_HUMAN	Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1)	MFN1	Homo sapiens (Human)	741	FUNCTION: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303). {ECO:0000269|PubMed:12475957, ECO:0000269|PubMed:12759376, ECO:0000269|PubMed:27920125, ECO:0000269|PubMed:28114303}.	MISCELLANEOUS: A truncated MFN1 construct containing the GTPase domain and the associated helix bundle is a monomer in the absence of bound GTP and a homodimer in the GTP-bound form; GDP cannot replace GTP and induce dimerization. {ECO:0000269|PubMed:27920125, ECO:0000269|PubMed:28114303}.	GTP metabolic process [GO:0046039]; mitochondrial fusion [GO:0008053]; mitochondrion localization [GO:0051646]; positive regulation of mitochondrial membrane potential [GO:0010918]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; outer mitochondrial membrane protein complex [GO:0098799]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; outer mitochondrial membrane protein complex [GO:0098799]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; GTP metabolic process [GO:0046039]; mitochondrial fusion [GO:0008053]; mitochondrion localization [GO:0051646]; positive regulation of mitochondrial membrane potential [GO:0010918]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:12759376, ECO:0000305|PubMed:27920125}; Multi-pass membrane protein {ECO:0000305|PubMed:12759376}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11751411}.
Q8IWA5	reviewed	CTL2_HUMAN	Choline transporter-like protein 2 (Solute carrier family 44 member 2)	SLC44A2 CTL2 PSEC0210	Homo sapiens (Human)	706	FUNCTION: [Isoform 1]: Choline/H+ antiporter, mainly in mitochodria (PubMed:10677542, PubMed:20665236, PubMed:33789160, PubMed:23651124). Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway (PubMed:33789160). {ECO:0000269|PubMed:10677542, ECO:0000269|PubMed:20665236, ECO:0000269|PubMed:23651124, ECO:0000269|PubMed:33789160}.; FUNCTION: [Isoform 3]: Does not exhibit choline transporter activity. {ECO:0000269|PubMed:10677542, ECO:0000269|PubMed:20665236}.	MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000305}.	choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; transmembrane transport [GO:0055085]	extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]; transmembrane transporter activity [GO:0022857]	extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]; transmembrane transporter activity [GO:0022857]; choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:33789160}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000305|PubMed:33789160}; Multi-pass membrane protein {ECO:0000255}. Note=Mainly expressed in mitochondria. {ECO:0000250|UniProtKB:B4F795}.
Q8IWB1	reviewed	IPRI_HUMAN	Inositol 1,4,5-trisphosphate receptor-interacting protein (Protein DANGER)	ITPRIP DANGER KIAA1754	Homo sapiens (Human)	547	FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release. {ECO:0000269|PubMed:16990268}.		extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]	membrane [GO:0016020]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]	protein kinase inhibitor activity [GO:0004860]	membrane [GO:0016020]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; protein kinase inhibitor activity [GO:0004860]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16990268}; Single-pass type I membrane protein. Nucleus outer membrane {ECO:0000250|UniProtKB:Q3TNL8}; Single-pass type I membrane protein {ECO:0000255}.
Q8IWB6	reviewed	TEX14_HUMAN	Inactive serine/threonine-protein kinase TEX14 (Protein kinase-like protein SgK307) (Sugen kinase 307) (Testis-expressed sequence 14) (Testis-expressed sequence 14 protein)	TEX14 SGK307	Homo sapiens (Human)	1497	FUNCTION: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity). {ECO:0000250}.		attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; cellular response to leukemia inhibitory factor [GO:1990830]; intercellular bridge organization [GO:0043063]; male meiotic nuclear division [GO:0007140]; mitotic sister chromatid separation [GO:0051306]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of cytokinesis [GO:0032466]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; midbody [GO:0030496]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; midbody [GO:0030496]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; cellular response to leukemia inhibitory factor [GO:1990830]; intercellular bridge organization [GO:0043063]; male meiotic nuclear division [GO:0007140]; mitotic sister chromatid separation [GO:0051306]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of cytokinesis [GO:0032466]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Midbody {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. {ECO:0000250}.
Q8IWB7	reviewed	WDFY1_HUMAN	WD repeat and FYVE domain-containing protein 1 (FYVE domain-containing protein localized to endosomes 1) (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17)	WDFY1 FENS1 KIAA1435 WDF1 ZFYVE17	Homo sapiens (Human)	410	FUNCTION: Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436). {ECO:0000269|PubMed:25736436}.		positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]	cell junction [GO:0030054]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]	1-phosphatidylinositol binding [GO:0005545]; zinc ion binding [GO:0008270]	cell junction [GO:0030054]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]; 1-phosphatidylinositol binding [GO:0005545]; zinc ion binding [GO:0008270]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:11739631, ECO:0000269|PubMed:25736436}.
Q8IWC1	reviewed	MA7D3_HUMAN	MAP7 domain-containing protein 3	MAP7D3 MDP3	Homo sapiens (Human)	876	FUNCTION: Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}.		microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]	cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819]	microtubule binding [GO:0008017]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15561729}. Note=Localizes to the microtubules throughout mitosis. {ECO:0000269|PubMed:22142902}.
Q8IWD4	reviewed	CC117_HUMAN	Coiled-coil domain-containing protein 117	CCDC117	Homo sapiens (Human)	279	FUNCTION: Facilitates DNA repair, cell cycle progression, and cell proliferation through its interaction with CIAO2B. {ECO:0000269|PubMed:30742009}.		positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA repair [GO:0045739]	cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA repair [GO:0045739]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:30742009}. Nucleus {ECO:0000269|PubMed:30742009}. Note=Mitotic spindle. {ECO:0000269|PubMed:30742009}.
Q8IWE2	reviewed	NXP20_HUMAN	Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1)	FAM114A1 NOXP20	Homo sapiens (Human)	563	FUNCTION: May play a role in neuronal cell development. {ECO:0000250}.			cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8IWE4	reviewed	DCNL3_HUMAN	DCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3)	DCUN1D3 SCCRO3	Homo sapiens (Human)	304	FUNCTION: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage (PubMed:23201271, PubMed:19617556, PubMed:27542266, PubMed:18823379). At the cell membrane, can promote and as well inhibit cullins neddylation (PubMed:19617556, PubMed:26906416, PubMed:25349211). {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416, ECO:0000269|PubMed:27542266}.		negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of protein neddylation [GO:2000435]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]; regulation of cell cycle process [GO:0010564]; regulation of protein neddylation [GO:2000434]; response to gamma radiation [GO:0010332]; response to UV-C [GO:0010225]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of protein neddylation [GO:2000435]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]; regulation of cell cycle process [GO:0010564]; regulation of protein neddylation [GO:2000434]; response to gamma radiation [GO:0010332]; response to UV-C [GO:0010225]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416}. Cytoplasm {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:26906416}. Nucleus {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:26906416}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18823379}. Note=After UVC treatment, the protein enters to the nucleus gradually (PubMed:18823379). Cell membrane localization is essential for CUL3 neddylation (PubMed:19617556). {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:19617556}.
Q8IWE5	reviewed	PKHM2_HUMAN	Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein)	PLEKHM2 KIAA0842 SKIP	Homo sapiens (Human)	1019	FUNCTION: Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:28325809, PubMed:22172677, PubMed:25898167, PubMed:24088571). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}.		Golgi organization [GO:0007030]; lysosome localization [GO:0032418]; natural killer cell mediated cytotoxicity [GO:0042267]; regulation of protein localization [GO:0032880]	endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]	kinesin binding [GO:0019894]	endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; kinesin binding [GO:0019894]; Golgi organization [GO:0007030]; lysosome localization [GO:0032418]; natural killer cell mediated cytotoxicity [GO:0042267]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15905402}. Lysosome membrane {ECO:0000269|PubMed:22172677}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:22172677}.
Q8IWF2	reviewed	FXRD2_HUMAN	FAD-dependent oxidoreductase domain-containing protein 2 (Endoplasmic reticulum flavoprotein associated with degradation)	FOXRED2 ERFAD	Homo sapiens (Human)	684	FUNCTION: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. {ECO:0000269|PubMed:19706418}.		ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum lumen [GO:0005788]	flavin adenine dinucleotide binding [GO:0050660]; monooxygenase activity [GO:0004497]	endoplasmic reticulum lumen [GO:0005788]; flavin adenine dinucleotide binding [GO:0050660]; monooxygenase activity [GO:0004497]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:19706418}.
Q8IWG1	reviewed	DNAI3_HUMAN	Dynein axonemal intermediate chain 3 (Testis development protein NYD-SP29) (WD repeat-containing protein 63)	DNAI3 WDR63	Homo sapiens (Human)	891	FUNCTION: Acts as a negative regulator of cell migration, invasion, and metastasis downstream of p53/TP53, through inhibition of Arp2/3 complex-mediated actin polymerization (PubMed:32128961). Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function (By similarity). May play a role in osteogenesis of dental tissue-derived mesenchymal stem cells (By similarity). {ECO:0000250|UniProtKB:B2RY71, ECO:0000269|PubMed:32128961}.		cilium movement involved in cell motility [GO:0060294]; inner dynein arm assembly [GO:0036159]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of cell migration [GO:0030336]; positive regulation of osteoblast differentiation [GO:0045669]	axonemal dynein complex [GO:0005858]; cytoplasm [GO:0005737]; inner dynein arm [GO:0036156]	Arp2/3 complex binding [GO:0071933]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]	axonemal dynein complex [GO:0005858]; cytoplasm [GO:0005737]; inner dynein arm [GO:0036156]; Arp2/3 complex binding [GO:0071933]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; cilium movement involved in cell motility [GO:0060294]; inner dynein arm assembly [GO:0036159]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of cell migration [GO:0030336]; positive regulation of osteoblast differentiation [GO:0045669]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32128961}.
Q8IWI9	reviewed	MGAP_HUMAN	MAX gene-associated protein (MAX dimerization protein 5)	MGA KIAA0518 MAD5	Homo sapiens (Human)	3065	FUNCTION: Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity). {ECO:0000250}.		cell fate specification [GO:0001708]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell fate specification [GO:0001708]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IWJ2	reviewed	GCC2_HUMAN	GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53)	GCC2 KIAA0336 RANBP2L4	Homo sapiens (Human)	1684	FUNCTION: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	Golgi ribbon formation [GO:0090161]; late endosome to Golgi transport [GO:0034499]; microtubule anchoring [GO:0034453]; microtubule organizing center organization [GO:0031023]; protein localization to Golgi apparatus [GO:0034067]; protein targeting to lysosome [GO:0006622]; recycling endosome to Golgi transport [GO:0071955]; regulation of protein exit from endoplasmic reticulum [GO:0070861]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]	identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; Golgi ribbon formation [GO:0090161]; late endosome to Golgi transport [GO:0034499]; microtubule anchoring [GO:0034453]; microtubule organizing center organization [GO:0031023]; protein localization to Golgi apparatus [GO:0034067]; protein targeting to lysosome [GO:0006622]; recycling endosome to Golgi transport [GO:0071955]; regulation of protein exit from endoplasmic reticulum [GO:0070861]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Q8IWK6	reviewed	AGRA3_HUMAN	Adhesion G protein-coupled receptor A3 (G-protein coupled receptor 125)	ADGRA3 GPR125 UNQ556/PRO1113	Homo sapiens (Human)	1321	FUNCTION: Orphan receptor that may have a role in planar cell polarity pathway. {ECO:0000250|UniProtKB:S4X0Q8}.	MISCELLANEOUS: Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRA3 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain. {ECO:0000305}.	cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:S4X0Q8}; Multi-pass membrane protein {ECO:0000255}.
Q8IWL1	reviewed	SFPA2_HUMAN	Pulmonary surfactant-associated protein A2 (PSP-A) (PSPA) (SP-A) (SP-A2) (35 kDa pulmonary surfactant-associated protein) (Alveolar proteinosis protein) (Collectin-5)	SFTPA2 COLEC5 PSAP SFTP1 SFTPA SFTPA2B	Homo sapiens (Human)	248	FUNCTION: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.	MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).	respiratory gaseous exchange by respiratory system [GO:0007585]	clathrin-coated endocytic vesicle [GO:0045334]; collagen trimer [GO:0005581]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; multivesicular body [GO:0005771]	carbohydrate binding [GO:0030246]	clathrin-coated endocytic vesicle [GO:0045334]; collagen trimer [GO:0005581]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; multivesicular body [GO:0005771]; carbohydrate binding [GO:0030246]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26792177, ECO:0000269|PubMed:32855221}. Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
Q8IWL2	reviewed	SFTA1_HUMAN	Pulmonary surfactant-associated protein A1 (PSP-A) (PSPA) (SP-A) (SP-A1) (35 kDa pulmonary surfactant-associated protein) (Alveolar proteinosis protein) (Collectin-4)	SFTPA1 COLEC4 PSAP SFTP1 SFTPA SFTPA1B	Homo sapiens (Human)	248	FUNCTION: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity). {ECO:0000250|UniProtKB:P35242}.; FUNCTION: (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule (PubMed:17158455, PubMed:21203928). Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages (PubMed:21123169). {ECO:0000269|PubMed:17158455, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:21203928}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen (PubMed:15845487, PubMed:25139904). When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen (PubMed:25139904). {ECO:0000269|PubMed:15845487, ECO:0000269|PubMed:25139904}.	MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).	opsonization [GO:0008228]; respiratory gaseous exchange by respiratory system [GO:0007585]	clathrin-coated endocytic vesicle [GO:0045334]; collagen trimer [GO:0005581]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; multivesicular body [GO:0005771]	carbohydrate binding [GO:0030246]; lipid transporter activity [GO:0005319]	clathrin-coated endocytic vesicle [GO:0045334]; collagen trimer [GO:0005581]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; multivesicular body [GO:0005771]; carbohydrate binding [GO:0030246]; lipid transporter activity [GO:0005319]; opsonization [GO:0008228]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26792177, ECO:0000269|PubMed:32855221}. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted, extracellular space, surface film {ECO:0000305}.
Q8IWL3	reviewed	HSC20_HUMAN	Iron-sulfur cluster co-chaperone protein HscB (DnaJ homolog subfamily C member 20) [Cleaved into: Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic (C-HSC20); Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]	HSCB DNAJC20 HSC20	Homo sapiens (Human)	235	FUNCTION: [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria (PubMed:20668094). Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain (PubMed:26749241). Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (PubMed:26749241). Plays an essential role in hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8K3A0, ECO:0000269|PubMed:20668094, ECO:0000269|PubMed:26749241}.; FUNCTION: [Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Acts as a co-chaperone in iron-sulfur cluster assembly in the cytoplasm (PubMed:29309586). Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1 (PubMed:29309586). This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT (PubMed:29309586). {ECO:0000269|PubMed:29309586}.		[2Fe-2S] cluster assembly [GO:0044571]; iron-sulfur cluster assembly [GO:0016226]; primitive erythrocyte differentiation [GO:0060319]; primitive hemopoiesis [GO:0060215]; protein complex oligomerization [GO:0051259]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	ATPase activator activity [GO:0001671]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ATPase activator activity [GO:0001671]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; [2Fe-2S] cluster assembly [GO:0044571]; iron-sulfur cluster assembly [GO:0016226]; primitive erythrocyte differentiation [GO:0060319]; primitive hemopoiesis [GO:0060215]; protein complex oligomerization [GO:0051259]	SUBCELLULAR LOCATION: [Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Cytoplasm {ECO:0000269|PubMed:20668094, ECO:0000269|PubMed:29309586}.; SUBCELLULAR LOCATION: [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Mitochondrion {ECO:0000269|PubMed:20668094}.
Q8IWL8	reviewed	STH_HUMAN	Saitohin	STH	Homo sapiens (Human)	128		MISCELLANEOUS: Was called 'saitohin' in honor of the late Tsuanao Saitoh and his laboratory.	positive regulation of mRNA splicing, via spliceosome [GO:0048026]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16186110}. Nucleus {ECO:0000269|PubMed:16186110}.
Q8IWN7	reviewed	RP1L1_HUMAN	Retinitis pigmentosa 1-like 1 protein	RP1L1	Homo sapiens (Human)	2400	FUNCTION: Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	axoneme assembly [GO:0035082]; intracellular signal transduction [GO:0035556]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	axoneme [GO:0005930]; microtubule [GO:0005874]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]		axoneme [GO:0005930]; microtubule [GO:0005874]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; axoneme assembly [GO:0035082]; intracellular signal transduction [GO:0035556]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Note=Localized to the axoneme of outer segments and connecting cilia in rod photoreceptors. {ECO:0000250}.
Q8IWQ3	reviewed	BRSK2_HUMAN	Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A)	BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12	Homo sapiens (Human)	736	FUNCTION: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}.		actin cytoskeleton organization [GO:0030036]; axonogenesis [GO:0007409]; cell division [GO:0051301]; ERAD pathway [GO:0036503]; establishment of cell polarity [GO:0030010]; exocytosis [GO:0006887]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; neuron differentiation [GO:0030182]; protein phosphorylation [GO:0006468]; regulation of ATP-dependent activity [GO:0043462]; regulation of axonogenesis [GO:0050770]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of neuron projection development [GO:0010975]; regulation of retrograde protein transport, ER to cytosol [GO:1904152]; regulation of synaptic vesicle clustering [GO:2000807]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; distal axon [GO:0150034]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; ATPase binding [GO:0051117]; ATPase regulator activity [GO:0060590]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; distal axon [GO:0150034]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; ATPase regulator activity [GO:0060590]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; actin cytoskeleton organization [GO:0030036]; axonogenesis [GO:0007409]; cell division [GO:0051301]; ERAD pathway [GO:0036503]; establishment of cell polarity [GO:0030010]; exocytosis [GO:0006887]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; neuron differentiation [GO:0030182]; protein phosphorylation [GO:0006468]; regulation of ATP-dependent activity [GO:0043462]; regulation of axonogenesis [GO:0050770]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of neuron projection development [GO:0010975]; regulation of retrograde protein transport, ER to cytosol [GO:1904152]; regulation of synaptic vesicle clustering [GO:2000807]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin.
Q8IWR1	reviewed	TRI59_HUMAN	Tripartite motif-containing protein 59 (EC 2.3.2.27) (RING finger protein 104) (Tumor suppressor TSBF-1)	TRIM59 RNF104 TRIM57 TSBF1	Homo sapiens (Human)	403	FUNCTION: E3 ubiquitin ligase involved in different processes such as development and immune response (PubMed:22588174, PubMed:30231667). Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT (PubMed:22588174). Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1 (PubMed:30231667). On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation (PubMed:30231667). Acts also as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q922Y2, ECO:0000269|PubMed:22588174, ECO:0000269|PubMed:30231667}.		innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of viral entry into host cell [GO:0046597]; protein ubiquitination [GO:0016567]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of viral entry into host cell [GO:0046597]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22588174}; Single-pass membrane protein {ECO:0000305}.
Q8IWS0	reviewed	PHF6_HUMAN	PHD finger protein 6 (PHD-like zinc finger protein)	PHF6 CENP-31 KIAA1823	Homo sapiens (Human)	365	FUNCTION: Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}.		blastocyst hatching [GO:0001835]; negative regulation of transcription by RNA polymerase II [GO:0000122]	kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; phosphoprotein binding [GO:0051219]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; tubulin binding [GO:0015631]	kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; phosphoprotein binding [GO:0051219]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; tubulin binding [GO:0015631]; blastocyst hatching [GO:0001835]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}. Note=Nuclear, it particularly localizes to the nucleolus.
Q8IWT0	reviewed	ARCH_HUMAN	Protein archease (Protein ZBTB8OS) (Zinc finger and BTB domain-containing opposite strand protein 8)	ZBTB8OS ARCH	Homo sapiens (Human)	167	FUNCTION: Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. {ECO:0000269|PubMed:24870230}.		tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669]; metal ion binding [GO:0046872]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	
Q8IWT1	reviewed	SCN4B_HUMAN	Sodium channel subunit beta-4	SCN4B	Homo sapiens (Human)	228	FUNCTION: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. {ECO:0000269|PubMed:24297919}.		AV node cell action potential [GO:0086016]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; establishment of localization in cell [GO:0051649]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; positive regulation of sodium ion transport [GO:0010765]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518]	sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]	intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]; AV node cell action potential [GO:0086016]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; establishment of localization in cell [GO:0051649]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; positive regulation of sodium ion transport [GO:0010765]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24297919}; Single-pass type I membrane protein {ECO:0000269|PubMed:24297919}.
Q8IWT3	reviewed	CUL9_HUMAN	Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein)	CUL9 H7AP1 KIAA0708 PARC	Homo sapiens (Human)	2517	FUNCTION: Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328). {ECO:0000269|PubMed:12526791, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696}.		microtubule cytoskeleton organization [GO:0000226]; protein ubiquitination [GO:0016567]; regulation of mitotic nuclear division [GO:0007088]; ubiquitin-dependent protein catabolic process [GO:0006511]	cullin-RING ubiquitin ligase complex [GO:0031461]; cytosol [GO:0005829]	ATP binding [GO:0005524]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	cullin-RING ubiquitin ligase complex [GO:0031461]; cytosol [GO:0005829]; ATP binding [GO:0005524]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; microtubule cytoskeleton organization [GO:0000226]; protein ubiquitination [GO:0016567]; regulation of mitotic nuclear division [GO:0007088]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12526791}.
Q8IWT6	reviewed	LRC8A_HUMAN	Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1)	LRRC8A KIAA1437 LRRC8 SWELL1 UNQ221/PRO247	Homo sapiens (Human)	810	FUNCTION: Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:29769723, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24725410, PubMed:30095067, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (PubMed:33171122). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (PubMed:33171122). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Can form functional channels by itself (in vitro) (PubMed:26824658). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746). Also required for T-cell development (By similarity). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29371604). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:31270356, PubMed:33139539). {ECO:0000250|UniProtKB:Q80WG5, ECO:0000269|PubMed:14660746, ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26530471, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:29371604, ECO:0000269|PubMed:29769723, ECO:0000269|PubMed:30095067, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:33139539, ECO:0000269|PubMed:33171122}.		aspartate transmembrane transport [GO:0015810]; cell volume homeostasis [GO:0006884]; chloride transmembrane transport [GO:1902476]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; intracellular glucose homeostasis [GO:0001678]; monoatomic anion transmembrane transport [GO:0098656]; monoatomic anion transport [GO:0006820]; positive regulation of insulin secretion [GO:0032024]; positive regulation of myoblast differentiation [GO:0045663]; pre-B cell differentiation [GO:0002329]; protein hexamerization [GO:0034214]; response to osmotic stress [GO:0006970]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; taurine transport [GO:0015734]	cell surface [GO:0009986]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]	cyclic-GMP-AMP transmembrane transporter activity [GO:0140360]; identical protein binding [GO:0042802]; volume-sensitive anion channel activity [GO:0005225]	cell surface [GO:0009986]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]; cyclic-GMP-AMP transmembrane transporter activity [GO:0140360]; identical protein binding [GO:0042802]; volume-sensitive anion channel activity [GO:0005225]; aspartate transmembrane transport [GO:0015810]; cell volume homeostasis [GO:0006884]; chloride transmembrane transport [GO:1902476]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; intracellular glucose homeostasis [GO:0001678]; monoatomic anion transmembrane transport [GO:0098656]; monoatomic anion transport [GO:0006820]; positive regulation of insulin secretion [GO:0032024]; positive regulation of myoblast differentiation [GO:0045663]; pre-B cell differentiation [GO:0002329]; protein hexamerization [GO:0034214]; response to osmotic stress [GO:0006970]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; taurine transport [GO:0015734]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000305|PubMed:29769723}; Multi-pass membrane protein {ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:30095067, ECO:0000269|PubMed:30127360}. Lysosome membrane {ECO:0000269|PubMed:33139539}; Multi-pass membrane protein {ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:30095067, ECO:0000269|PubMed:30127360}. Note=Mainly localizes to the cell membrane, with some intracellular localization to lysosomes. {ECO:0000269|PubMed:33139539}.
Q8IWU2	reviewed	LMTK2_HUMAN	Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2)	LMTK2 AATYK2 BREK KIAA1079 KPI2 LMR2	Homo sapiens (Human)	1503	FUNCTION: Phosphorylates PPP1C, phosphorylase b and CFTR.		early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; receptor recycling [GO:0001881]; transferrin transport [GO:0033572]	cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]	ATP binding [GO:0005524]; myosin VI binding [GO:0070853]; protein kinase activity [GO:0004672]; protein phosphatase inhibitor activity [GO:0004864]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; ATP binding [GO:0005524]; myosin VI binding [GO:0070853]; protein kinase activity [GO:0004672]; protein phosphatase inhibitor activity [GO:0004864]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; receptor recycling [GO:0001881]; transferrin transport [GO:0033572]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:23114966}; Multi-pass membrane protein {ECO:0000269|PubMed:23114966}.
Q8IWU4	reviewed	ZNT8_HUMAN	Proton-coupled zinc antiporter SLC30A8 (Solute carrier family 30 member 8) (Zinc transporter 8) (ZnT-8)	SLC30A8 ZNT8	Homo sapiens (Human)	369	FUNCTION: Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion. {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16984975, ECO:0000269|PubMed:27875315, ECO:0000269|PubMed:32723473}.	MISCELLANEOUS: Each subunit of the homodimer independently transports zinc ions in a pH-dependent manner. The cytosolic pH promotes binding of zinc ions to the transporter binding site. Upon change into the organelle-facing conformation, the two histidines of the zinc-binding site get protonated at lumenal lower pH, triggering zinc release into the organelle. The transporter then moves back to the cytosolic-facing conformation where the two histidines get deprotonated at higher pH, resulting in a net antiport of 2 protons. {ECO:0000303|PubMed:32723473}.	insulin processing [GO:0030070]; insulin secretion [GO:0030073]; intracellular zinc ion homeostasis [GO:0006882]; positive regulation of insulin secretion [GO:0032024]; regulation of sequestering of zinc ion [GO:0061088]; regulation of vesicle-mediated transport [GO:0060627]; response to glucose [GO:0009749]; response to interleukin-1 [GO:0070555]; response to type II interferon [GO:0034341]; response to zinc ion [GO:0010043]; sequestering of zinc ion [GO:0032119]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	cytoplasmic vesicle [GO:0031410]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]	protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826]	cytoplasmic vesicle [GO:0031410]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826]; insulin processing [GO:0030070]; insulin secretion [GO:0030073]; intracellular zinc ion homeostasis [GO:0006882]; positive regulation of insulin secretion [GO:0032024]; regulation of sequestering of zinc ion [GO:0061088]; regulation of vesicle-mediated transport [GO:0060627]; response to glucose [GO:0009749]; response to interleukin-1 [GO:0070555]; response to type II interferon [GO:0034341]; response to zinc ion [GO:0010043]; sequestering of zinc ion [GO:0032119]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16984975}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16984975}; Multi-pass membrane protein {ECO:0000255}. Note=Associated with insulin and glucagon secretory granules. {ECO:0000269|PubMed:15331542}.
Q8IWU5	reviewed	SULF2_HUMAN	Extracellular sulfatase Sulf-2 (hSulf-2) (Arylsulfatase) (EC 3.1.6.1) (N-acetylglucosamine-6-sulfatase) (EC 3.1.6.14) [Cleaved into: Extracellular sulfatase Sulf-2 secreted form]	SULF2 KIAA1247 UNQ559/PRO1120	Homo sapiens (Human)	870	FUNCTION: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:30788513, PubMed:35294879). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:30788513, PubMed:35294879). {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:30788513, ECO:0000269|PubMed:35294879}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site. {ECO:0000305}.	bone development [GO:0060348]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; kidney development [GO:0001822]; liver regeneration [GO:0097421]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of hepatocyte proliferation [GO:2000345]; response to wounding [GO:0009611]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi stack [GO:0005795]; plasma membrane [GO:0005886]	arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi stack [GO:0005795]; plasma membrane [GO:0005886]; arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]; bone development [GO:0060348]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; kidney development [GO:0001822]; liver regeneration [GO:0097421]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of hepatocyte proliferation [GO:2000345]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VI60}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:Q8VI60}. Cell surface {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:35294879}.; SUBCELLULAR LOCATION: [Extracellular sulfatase Sulf-2 secreted form]: Secreted {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:30788513, ECO:0000269|PubMed:35294879}.
Q8IWU6	reviewed	SULF1_HUMAN	Extracellular sulfatase Sulf-1 (hSulf-1) (Arylsulfatase) (EC 3.1.6.1) (N-acetylglucosamine-6-sulfatase) (EC 3.1.6.14) [Cleaved into: Extracellular sulfatase Sulf-2 secreted form]	SULF1 KIAA1077	Homo sapiens (Human)	871	FUNCTION: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:12686563). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:12686563). Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (PubMed:12686563). {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:12686563}.		apoptotic process [GO:0006915]; bone development [GO:0060348]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of prostatic bud formation [GO:0060686]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]; apoptotic process [GO:0006915]; bone development [GO:0060348]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of prostatic bud formation [GO:0060686]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VI60}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:Q8VI60}. Cell surface {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:12686563}.; SUBCELLULAR LOCATION: [Extracellular sulfatase Sulf-2 secreted form]: Secreted {ECO:0000269|PubMed:12368295}.
Q8IWU9	reviewed	TPH2_HUMAN	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2)	TPH2 NTPH	Homo sapiens (Human)	490			aromatic amino acid metabolic process [GO:0009072]; serotonin biosynthetic process [GO:0042427]	cytosol [GO:0005829]; neuron projection [GO:0043005]	iron ion binding [GO:0005506]; tryptophan 5-monooxygenase activity [GO:0004510]	cytosol [GO:0005829]; neuron projection [GO:0043005]; iron ion binding [GO:0005506]; tryptophan 5-monooxygenase activity [GO:0004510]; aromatic amino acid metabolic process [GO:0009072]; serotonin biosynthetic process [GO:0042427]	
Q8IWV1	reviewed	LAX1_HUMAN	Lymphocyte transmembrane adapter 1 (Linker for activation of X cells) (Membrane-associated adapter protein LAX)	LAX1 LAX	Homo sapiens (Human)	398	FUNCTION: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. {ECO:0000269|PubMed:12359715}.		adaptive immune response [GO:0002250]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell activation [GO:0042113]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; lymphocyte activation [GO:0046649]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of T cell activation [GO:0050868]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]	protein kinase binding [GO:0019901]; SH2 domain binding [GO:0042169]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein kinase binding [GO:0019901]; SH2 domain binding [GO:0042169]; adaptive immune response [GO:0002250]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell activation [GO:0042113]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; lymphocyte activation [GO:0046649]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of T cell activation [GO:0050868]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12359715}; Single-pass type III membrane protein {ECO:0000269|PubMed:12359715}.
Q8IWV2	reviewed	CNTN4_HUMAN	Contactin-4 (Brain-derived immunoglobulin superfamily protein 2) (BIG-2)	CNTN4	Homo sapiens (Human)	1026	FUNCTION: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.		axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; brain development [GO:0007420]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron differentiation [GO:0045665]; nervous system development [GO:0007399]; neuron cell-cell adhesion [GO:0007158]; neuron projection development [GO:0031175]; regulation of synaptic plasticity [GO:0048167]	axon [GO:0030424]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	cell-cell adhesion mediator activity [GO:0098632]	axon [GO:0030424]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell-cell adhesion mediator activity [GO:0098632]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; brain development [GO:0007420]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron differentiation [GO:0045665]; nervous system development [GO:0007399]; neuron cell-cell adhesion [GO:0007158]; neuron projection development [GO:0031175]; regulation of synaptic plasticity [GO:0048167]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000250}.
Q8IWV7	reviewed	UBR1_HUMAN	E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (RING-type E3 ubiquitin transferase UBR1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I)	UBR1	Homo sapiens (Human)	1749	FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242}.		cellular response to leucine [GO:0071233]; negative regulation of TOR signaling [GO:0032007]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; proteasome complex [GO:0000502]; ubiquitin ligase complex [GO:0000151]	leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; proteasome complex [GO:0000502]; ubiquitin ligase complex [GO:0000151]; leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; cellular response to leucine [GO:0071233]; negative regulation of TOR signaling [GO:0032007]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16311597}.
Q8IWV8	reviewed	UBR2_HUMAN	E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (RING-type E3 ubiquitin transferase UBR2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II)	UBR2 C6orf133 KIAA0349	Homo sapiens (Human)	1755	FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:20835242). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (By similarity). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed:20298436). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity). Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis (By similarity). {ECO:0000250|UniProtKB:Q6WKZ8, ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242}.	MISCELLANEOUS: [Isoform 4]: Derived from mouse cDNA data. {ECO:0000305}.	cellular response to leucine [GO:0071233]; heterochromatin formation [GO:0031507]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; negative regulation of TOR signaling [GO:0032007]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	histone ubiquitin ligase activity [GO:0140852]; leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; histone ubiquitin ligase activity [GO:0140852]; leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; cellular response to leucine [GO:0071233]; heterochromatin formation [GO:0031507]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; negative regulation of TOR signaling [GO:0032007]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6WKZ8}. Chromosome {ECO:0000250|UniProtKB:Q6WKZ8}. Note=Associated with chromatin during meiosis. {ECO:0000250|UniProtKB:Q6WKZ8}.
Q8IWW6	reviewed	RHG12_HUMAN	Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12)	ARHGAP12	Homo sapiens (Human)	846	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.		actin filament organization [GO:0007015]; morphogenesis of an epithelial sheet [GO:0002011]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; phagocytic cup [GO:0001891]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; phagocytic cup [GO:0001891]; GTPase activator activity [GO:0005096]; actin filament organization [GO:0007015]; morphogenesis of an epithelial sheet [GO:0002011]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; signal transduction [GO:0007165]	
Q8IWW8	reviewed	HOT_HUMAN	Hydroxyacid-oxoacid transhydrogenase, mitochondrial (HOT) (EC 1.1.99.24) (Alcohol dehydrogenase iron-containing protein 1) (ADHFe1) (Fe-containing alcohol dehydrogenase)	ADHFE1 HMFT2263	Homo sapiens (Human)	467	FUNCTION: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. {ECO:0000269|PubMed:16435184}.		2-oxoglutarate metabolic process [GO:0006103]; glutamate catabolic process via 2-oxoglutarate [GO:0006539]; lipid metabolic process [GO:0006629]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	alcohol dehydrogenase (NAD+) activity [GO:0004022]; hydroxyacid-oxoacid transhydrogenase activity [GO:0047988]; metal ion binding [GO:0046872]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; alcohol dehydrogenase (NAD+) activity [GO:0004022]; hydroxyacid-oxoacid transhydrogenase activity [GO:0047988]; metal ion binding [GO:0046872]; 2-oxoglutarate metabolic process [GO:0006103]; glutamate catabolic process via 2-oxoglutarate [GO:0006539]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
Q8IWX5	reviewed	SGPP2_HUMAN	Sphingosine-1-phosphate phosphatase 2 (SPPase2) (Spp2) (hSPP2) (EC 3.1.3.-) (Sphingosine-1-phosphatase 2)	SGPP2	Homo sapiens (Human)	399	FUNCTION: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (PubMed:12411432). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (PubMed:17113265). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity). {ECO:0000250|UniProtKB:Q810K3, ECO:0000250|UniProtKB:Q9BX95, ECO:0000269|PubMed:12411432, ECO:0000269|PubMed:17113265, ECO:0000269|PubMed:31916624}.		phospholipid dephosphorylation [GO:0046839]; regulation of type B pancreatic cell proliferation [GO:0061469]; sphingolipid biosynthetic process [GO:0030148]; sphingosine metabolic process [GO:0006670]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	dihydrosphingosine-1-phosphate phosphatase activity [GO:0070780]; sphingosine-1-phosphate phosphatase activity [GO:0042392]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; dihydrosphingosine-1-phosphate phosphatase activity [GO:0070780]; sphingosine-1-phosphate phosphatase activity [GO:0042392]; phospholipid dephosphorylation [GO:0046839]; regulation of type B pancreatic cell proliferation [GO:0061469]; sphingolipid biosynthetic process [GO:0030148]; sphingosine metabolic process [GO:0006670]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12411432}; Multi-pass membrane protein {ECO:0000269|PubMed:12411432}.
Q8IWX7	reviewed	UN45B_HUMAN	Protein unc-45 homolog B (Unc-45B) (SMUNC45)	UNC45B CMYA4 UNC45	Homo sapiens (Human)	931	FUNCTION: Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development. {ECO:0000250|UniProtKB:Q6DGE9, ECO:0000250|UniProtKB:Q8CGY6}.		cell differentiation [GO:0030154]; chaperone-mediated protein folding [GO:0061077]; lens development in camera-type eye [GO:0002088]; muscle organ development [GO:0007517]	A band [GO:0031672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018]	Hsp90 protein binding [GO:0051879]	A band [GO:0031672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018]; Hsp90 protein binding [GO:0051879]; cell differentiation [GO:0030154]; chaperone-mediated protein folding [GO:0061077]; lens development in camera-type eye [GO:0002088]; muscle organ development [GO:0007517]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, myofibril, sarcomere, A band {ECO:0000269|PubMed:33217308}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8CGY6}. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage. {ECO:0000250|UniProtKB:Q6DGE9}.
Q8IWX8	reviewed	CHERP_HUMAN	Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6)	CHERP DAN26 SCAF6	Homo sapiens (Human)	916	FUNCTION: Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}.		intracellular calcium ion homeostasis [GO:0006874]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; release of sequestered calcium ion into cytosol [GO:0051209]; RNA processing [GO:0006396]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum membrane [GO:0033017]	RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum membrane [GO:0033017]; RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; release of sequestered calcium ion into cytosol [GO:0051209]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674, ECO:0000269|PubMed:8010949}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674, ECO:0000269|PubMed:8010949}. Endoplasmic reticulum {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674, ECO:0000269|PubMed:8010949}. Note=Distributed throughout the cytoplasm and also localizes to the perinuclear region of both human erythroleukemia (HEL) cells and Jurkat cells. Colocalizes with ITPR1. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674, ECO:0000269|PubMed:8010949}.
Q8IWY4	reviewed	SCUB1_HUMAN	Signal peptide, CUB and EGF-like domain-containing protein 1	SCUBE1	Homo sapiens (Human)	988	FUNCTION: Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. {ECO:0000269|PubMed:16753137}.		adult heart development [GO:0007512]; blood coagulation [GO:0007596]; endothelial cell differentiation [GO:0045446]; inflammatory response [GO:0006954]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; signal transduction [GO:0007165]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; adult heart development [GO:0007512]; blood coagulation [GO:0007596]; endothelial cell differentiation [GO:0045446]; inflammatory response [GO:0006954]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12270931, ECO:0000269|PubMed:16753137}. Cell membrane {ECO:0000269|PubMed:16753137}; Peripheral membrane protein {ECO:0000269|PubMed:16753137}.
Q8IWY9	reviewed	CDAN1_HUMAN	Codanin-1	CDAN1 UNQ664/PRO1295	Homo sapiens (Human)	1227	FUNCTION: May act as a negative regulator of ASF1 in chromatin assembly. {ECO:0000269|PubMed:22407294}.		chromatin organization [GO:0006325]; import into nucleus [GO:0051170]; protein localization [GO:0008104]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; chromatin organization [GO:0006325]; import into nucleus [GO:0051170]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Mainly detected as a cytoplasmic protein.
Q8IWZ3	reviewed	ANKH1_HUMAN	Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK)	ANKHD1 KIAA1085 MASK VBARP PP2500	Homo sapiens (Human)	2542	FUNCTION: May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}.		innate immune response [GO:0045087]	cytoplasm [GO:0005737]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; RNA binding [GO:0003723]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16098192, ECO:0000269|PubMed:16956752}.
Q8IWZ4	reviewed	TRI48_HUMAN	E3 ubiquitin-protein ligase TRIM48 (EC 2.3.2.27) (RING finger protein 101) (Tripartite motif-containing protein 48)	TRIM48 RNF101	Homo sapiens (Human)	224	FUNCTION: E3 ubiquitin-protein ligase which promotes K48-linked polyubiquitination of protein methyltransferase PRMT1, leading to PRMT1 degradation (PubMed:29186683). This suppresses methylation of the PRMT1 substrate MAP3K5/ASK1, promoting its activation and increasing MAP3K5-dependent cell death induced by oxidative stress (PubMed:29186683). TRIM48-mediated ubiquitination of PRMT1 also suppresses methylation of FOXO1 by PRMT1, leading to inhibition of FOXO1 transcriptional activity (PubMed:29186683). {ECO:0000269|PubMed:29186683}.		innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:29186683}.
Q8IWZ5	reviewed	TRI42_HUMAN	Tripartite motif-containing protein 42	TRIM42	Homo sapiens (Human)	723				cellular anatomical entity [GO:0110165]	zinc ion binding [GO:0008270]	cellular anatomical entity [GO:0110165]; zinc ion binding [GO:0008270]	
Q8IWZ6	reviewed	BBS7_HUMAN	Bardet-Biedl syndrome 7 protein (BBS2-like protein 1)	BBS7 BBS2L1	Homo sapiens (Human)	715	FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.		brain development [GO:0007420]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; digestive tract morphogenesis [GO:0048546]; eye development [GO:0001654]; fat cell differentiation [GO:0045444]; heart looping [GO:0001947]; intracellular transport [GO:0046907]; limb development [GO:0060173]; melanosome transport [GO:0032402]; non-motile cilium assembly [GO:1905515]; pigment granule aggregation in cell center [GO:0051877]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; primary palate development [GO:1903929]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of transcription by RNA polymerase II [GO:0006357]; smoothened signaling pathway [GO:0007224]; visual perception [GO:0007601]	axoneme [GO:0005930]; BBSome [GO:0034464]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; photoreceptor outer segment [GO:0001750]	RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	axoneme [GO:0005930]; BBSome [GO:0034464]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; photoreceptor outer segment [GO:0001750]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; brain development [GO:0007420]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; digestive tract morphogenesis [GO:0048546]; eye development [GO:0001654]; fat cell differentiation [GO:0045444]; heart looping [GO:0001947]; intracellular transport [GO:0046907]; limb development [GO:0060173]; melanosome transport [GO:0032402]; non-motile cilium assembly [GO:1905515]; pigment granule aggregation in cell center [GO:0051877]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; primary palate development [GO:1903929]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of transcription by RNA polymerase II [GO:0006357]; smoothened signaling pathway [GO:0007224]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}. Cytoplasm {ECO:0000269|PubMed:22072986}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:22072986}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8K2G4}.
Q8IWZ8	reviewed	SUGP1_HUMAN	SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4)	SUGP1 SF4	Homo sapiens (Human)	645	FUNCTION: Plays a role in pre-mRNA splicing.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IX01	reviewed	SUGP2_HUMAN	SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14)	SUGP2 KIAA0365 SFRS14	Homo sapiens (Human)	1082	FUNCTION: May play a role in mRNA splicing. {ECO:0000305}.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IX03	reviewed	KIBRA_HUMAN	Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1)	WWC1 KIAA0869	Homo sapiens (Human)	1113	FUNCTION: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance (PubMed:15081397, PubMed:16684779, PubMed:18190796, PubMed:18596123, PubMed:18672031, PubMed:20159598, PubMed:23778582). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:15081397, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:23778582}.		cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of MAPK cascade [GO:0043410]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330]; regulation of intracellular transport [GO:0032386]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]	kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; transcription coactivator activity [GO:0003713]; cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of MAPK cascade [GO:0043410]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330]; regulation of intracellular transport [GO:0032386]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18596123}. Nucleus {ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18190796}. Note=Colocalizes with PRKCZ in the perinuclear region.
Q8IX04	reviewed	UEVLD_HUMAN	Ubiquitin-conjugating enzyme E2 variant 3 (UEV-3) (EV and lactate/malate dehydrogenase domain-containing protein)	UEVLD UEV3	Homo sapiens (Human)	471	FUNCTION: Possible negative regulator of polyubiquitination. {ECO:0000269|PubMed:12427560}.		carboxylic acid metabolic process [GO:0019752]; endosome to lysosome transport [GO:0008333]; protein modification process [GO:0036211]; protein transport [GO:0015031]	ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; ubiquitin binding [GO:0043130]	ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; ubiquitin binding [GO:0043130]; carboxylic acid metabolic process [GO:0019752]; endosome to lysosome transport [GO:0008333]; protein modification process [GO:0036211]; protein transport [GO:0015031]	
Q8IX05	reviewed	CD302_HUMAN	CD302 antigen (C-type lectin BIMLEC) (C-type lectin domain family 13 member A) (DEC205-associated C-type lectin 1) (Type I transmembrane C-type lectin receptor DCL-1) (CD antigen CD302)	CD302 CLEC13A DCL1 KIAA0022	Homo sapiens (Human)	232	FUNCTION: Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration. {ECO:0000269|PubMed:17947679}.	MISCELLANEOUS: Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.; MISCELLANEOUS: [Isoform 1]: Produced by intergenic splicing of LY75 and CD302.	phagocytosis [GO:0006909]	cell cortex [GO:0005938]; external side of plasma membrane [GO:0009897]; filopodium [GO:0030175]; membrane [GO:0016020]; microvillus [GO:0005902]	carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023]	cell cortex [GO:0005938]; external side of plasma membrane [GO:0009897]; filopodium [GO:0030175]; membrane [GO:0016020]; microvillus [GO:0005902]; carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023]; phagocytosis [GO:0006909]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, filopodium {ECO:0000269|PubMed:17947679}. Cytoplasm, cell cortex {ECO:0000269|PubMed:17947679}. Cell projection, microvillus {ECO:0000269|PubMed:17947679}. Note=Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.
Q8IX07	reviewed	FOG1_HUMAN	Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1)	ZFPM1 FOG1 ZFN89A	Homo sapiens (Human)	1006	FUNCTION: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.		atrial septum morphogenesis [GO:0060413]; atrioventricular valve morphogenesis [GO:0003181]; cardiac muscle tissue morphogenesis [GO:0055008]; definitive erythrocyte differentiation [GO:0060318]; embryonic hemopoiesis [GO:0035162]; erythrocyte differentiation [GO:0030218]; granulocyte differentiation [GO:0030851]; heart development [GO:0007507]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; mitral valve formation [GO:0003192]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of mast cell differentiation [GO:0060377]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; primitive erythrocyte differentiation [GO:0060319]; regulation of chemokine production [GO:0032642]; regulation of definitive erythrocyte differentiation [GO:0010724]; T-helper cell lineage commitment [GO:0002295]; tricuspid valve formation [GO:0003195]; ventricular septum morphogenesis [GO:0060412]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; atrial septum morphogenesis [GO:0060413]; atrioventricular valve morphogenesis [GO:0003181]; cardiac muscle tissue morphogenesis [GO:0055008]; definitive erythrocyte differentiation [GO:0060318]; embryonic hemopoiesis [GO:0035162]; erythrocyte differentiation [GO:0030218]; granulocyte differentiation [GO:0030851]; heart development [GO:0007507]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; mitral valve formation [GO:0003192]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of mast cell differentiation [GO:0060377]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; primitive erythrocyte differentiation [GO:0060319]; regulation of chemokine production [GO:0032642]; regulation of definitive erythrocyte differentiation [GO:0010724]; T-helper cell lineage commitment [GO:0002295]; tricuspid valve formation [GO:0003195]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8IX12	reviewed	CCAR1_HUMAN	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain)	CCAR1 CARP1 DIS	Homo sapiens (Human)	1150	FUNCTION: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	nuclear envelope lumen [GO:0005641]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]	nuclear envelope lumen [GO:0005641]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12816952}.
Q8IX15	reviewed	HOMEZ_HUMAN	Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper-containing factor)	HOMEZ KIAA1443	Homo sapiens (Human)	550	FUNCTION: May function as a transcriptional regulator.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12925734}.
Q8IX19	reviewed	MCEM1_HUMAN	Mast cell-expressed membrane protein 1	MCEMP1 C19orf59	Homo sapiens (Human)	187				plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	identical protein binding [GO:0042802]	plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
Q8IX21	reviewed	SLF2_HUMAN	SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1)	SLF2 C10orf6 FAM178A	Homo sapiens (Human)	1173	FUNCTION: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}.	MISCELLANEOUS: Localized in the locus associated with inherited infantile onset spinocerebellar ataxia (IOSCA). No mutation were found associated with IOSCA compared to control subjects. The expression level in the brain was not different between the 2 populations.	chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]	protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24561620, ECO:0000269|PubMed:25931565}. Nucleus, PML body {ECO:0000269|PubMed:36373674}. Note=Mainly localizes in the nucleus (PubMed:24561620). Colocalizes with PCNA on replication sites (PubMed:24561620). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). {ECO:0000269|PubMed:24561620, ECO:0000269|PubMed:25931565}.
Q8IX30	reviewed	SCUB3_HUMAN	Signal peptide, CUB and EGF-like domain-containing protein 3	SCUBE3 CEGF3	Homo sapiens (Human)	993	FUNCTION: Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development. It acts as coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors (PubMed:33308444). It is required for ligand-induced recruitment of BMP receptors to lipid rafts (By similarity). Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. {ECO:0000250|UniProtKB:Q6NZL8, ECO:0000269|PubMed:21441952, ECO:0000269|PubMed:33308444}.		positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of osteoblast differentiation [GO:0045669]; signal transduction [GO:0007165]	cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	BMP binding [GO:0036122]; BMP receptor binding [GO:0070700]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]	cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; BMP binding [GO:0036122]; BMP receptor binding [GO:0070700]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of osteoblast differentiation [GO:0045669]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15234972, ECO:0000269|PubMed:33308444}. Cell surface {ECO:0000269|PubMed:15234972, ECO:0000269|PubMed:33308444}.
Q8IX90	reviewed	SKA3_HUMAN	Spindle and kinetochore-associated protein 3	SKA3 C13orf3 RAMA1	Homo sapiens (Human)	412	FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; regulation of microtubule polymerization or depolymerization [GO:0031110]	centrosome [GO:0005813]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; outer kinetochore [GO:0000940]; spindle microtubule [GO:0005876]		centrosome [GO:0005813]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; outer kinetochore [GO:0000940]; spindle microtubule [GO:0005876]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; regulation of microtubule polymerization or depolymerization [GO:0031110]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:20813266}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. {ECO:0000269|PubMed:19360002}.
Q8IXA5	reviewed	SACA3_HUMAN	Sperm acrosome membrane-associated protein 3 (Cancer/testis antigen 54) (CT54) (Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17) (Lysozyme-like protein 3) (Sperm lysozyme-like protein 1) (Sperm protein reactive with antisperm antibodies) (Sperm protein reactive with ASA) [Cleaved into: Sperm acrosome membrane-associated protein 3, membrane form; Sperm acrosome membrane-associated protein 3, processed form]	SPACA3 LYC3 LYZL3 SLLP1 SPRASA UNQ424/PRO862	Homo sapiens (Human)	215	FUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. {ECO:0000269|PubMed:12606493}.		fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; monocyte activation [GO:0042117]; positive regulation of macrophage activation [GO:0043032]; positive regulation of phagocytosis [GO:0050766]; sperm-egg recognition [GO:0035036]	acrosomal matrix [GO:0043159]; acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; secretory granule [GO:0030141]; sperm flagellum [GO:0036126]		acrosomal matrix [GO:0043159]; acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; secretory granule [GO:0030141]; sperm flagellum [GO:0036126]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; monocyte activation [GO:0042117]; positive regulation of macrophage activation [GO:0043032]; positive regulation of phagocytosis [GO:0050766]; sperm-egg recognition [GO:0035036]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q8IXB1	reviewed	DJC10_HUMAN	DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr)	DNAJC10 ERDJ5 UNQ495/PRO1012	Homo sapiens (Human)	793	FUNCTION: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. {ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:18400946, ECO:0000269|PubMed:19122239, ECO:0000269|PubMed:23769672}.		intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of ATP-dependent activity [GO:0032781]; protein folding in endoplasmic reticulum [GO:0034975]; response to endoplasmic reticulum stress [GO:0034976]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]	ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; disulfide oxidoreductase activity [GO:0015036]; Hsp70 protein binding [GO:0030544]; misfolded protein binding [GO:0051787]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein-disulfide reductase activity [GO:0015035]; protein-folding chaperone binding [GO:0051087]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]; ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; disulfide oxidoreductase activity [GO:0015036]; Hsp70 protein binding [GO:0030544]; misfolded protein binding [GO:0051787]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein-disulfide reductase activity [GO:0015035]; protein-folding chaperone binding [GO:0051087]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of ATP-dependent activity [GO:0032781]; protein folding in endoplasmic reticulum [GO:0034975]; response to endoplasmic reticulum stress [GO:0034976]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:23769672}.
Q8IXB3	reviewed	TARG1_HUMAN	Trafficking regulator of GLUT4 1 (Dispanin subfamily B member 1) (DSPB1) (Interferon-induced transmembrane domain-containing protein D3) (Protein located at seventeen-p-thirteen point three 1) (Tumor suppressor candidate 5)	TRARG1 IFITMD3 LOST1 TUSC5	Homo sapiens (Human)	177	FUNCTION: Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. {ECO:0000250|UniProtKB:Q8C838}.		cellular response to insulin stimulus [GO:0032869]; endosome to plasma membrane protein transport [GO:0099638]; glucose import in response to insulin stimulus [GO:0044381]; protein localization to plasma membrane [GO:0072659]; vesicle fusion to plasma membrane [GO:0099500]	cytoplasmic vesicle membrane [GO:0030659]; endomembrane system [GO:0012505]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]		cytoplasmic vesicle membrane [GO:0030659]; endomembrane system [GO:0012505]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cellular response to insulin stimulus [GO:0032869]; endosome to plasma membrane protein transport [GO:0099638]; glucose import in response to insulin stimulus [GO:0044381]; protein localization to plasma membrane [GO:0072659]; vesicle fusion to plasma membrane [GO:0099500]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8C838}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8C838}. Endomembrane system {ECO:0000250|UniProtKB:Q8C838}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8C838}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8C838}. Note=Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation. {ECO:0000250|UniProtKB:Q8C838}.
Q8IXF0	reviewed	NPAS3_HUMAN	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6)	NPAS3 BHLHE12 MOP6 PASD6	Homo sapiens (Human)	933	FUNCTION: May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity). {ECO:0000250}.		positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:12746393}.
Q8IXH6	reviewed	T53I2_HUMAN	Tumor protein p53-inducible nuclear protein 2 (Diabetes and obesity-regulated gene) (p53-inducible protein U) (PIG-U)	TP53INP2 C20orf110 DOR PINH	Homo sapiens (Human)	220	FUNCTION: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. {ECO:0000269|PubMed:18030323, ECO:0000269|PubMed:19056683, ECO:0000269|PubMed:22470510}.		autophagosome assembly [GO:0000045]; negative regulation of protein localization [GO:1903828]; osteoblast differentiation [GO:0001649]; positive regulation of DNA-templated transcription [GO:0045893]; protein localization [GO:0008104]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; PML body [GO:0016605]	ubiquitin binding [GO:0043130]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; PML body [GO:0016605]; ubiquitin binding [GO:0043130]; autophagosome assembly [GO:0000045]; negative regulation of protein localization [GO:1903828]; osteoblast differentiation [GO:0001649]; positive regulation of DNA-templated transcription [GO:0045893]; protein localization [GO:0008104]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
Q8IXH7	reviewed	NELFD_HUMAN	Negative elongation factor C/D (NELF-C/D) (TH1-like protein)	NELFCD NELFD TH1 TH1L HSPC130	Homo sapiens (Human)	590	FUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}.	MISCELLANEOUS: [Isoform NELF-D]: Produced by alternative initiation at Met-10 of isoform NELF-C. {ECO:0000305}.	negative regulation of transcription elongation by RNA polymerase II [GO:0034244]	membrane [GO:0016020]; NELF complex [GO:0032021]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	membrane [GO:0016020]; NELF complex [GO:0032021]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IXH8	reviewed	CAD26_HUMAN	Cadherin-like protein 26 (Cadherin-like protein VR20)	CDH26	Homo sapiens (Human)	832	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation (PubMed:28051089). {ECO:0000269|PubMed:28051089}.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; CD4-positive, alpha-beta T cell activation [GO:0035710]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]	alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; delta-catenin binding [GO:0070097]; integrin binding [GO:0005178]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; delta-catenin binding [GO:0070097]; integrin binding [GO:0005178]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; CD4-positive, alpha-beta T cell activation [GO:0035710]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28051089}; Single-pass type I membrane protein {ECO:0000305|PubMed:28051089}.
Q8IXI1	reviewed	MIRO2_HUMAN	Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)	RHOT2 ARHT2 C16orf39	Homo sapiens (Human)	618	FUNCTION: Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). {ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657}.		actin filament organization [GO:0007015]; cellular homeostasis [GO:0019725]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrion organization [GO:0007005]; mitochondrion transport along microtubule [GO:0047497]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; actin filament organization [GO:0007015]; cellular homeostasis [GO:0019725]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrion organization [GO:0007005]; mitochondrion transport along microtubule [GO:0047497]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.
Q8IXI2	reviewed	MIRO1_HUMAN	Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1)	RHOT1 ARHT1	Homo sapiens (Human)	618	FUNCTION: Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657). Promotes mitochondrial fission during high calcium conditions (PubMed:27716788). {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:27716788}.		actin filament organization [GO:0007015]; cellular homeostasis [GO:0019725]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrion organization [GO:0007005]; mitochondrion transport along microtubule [GO:0047497]; regulation of mitochondrion organization [GO:0010821]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; actin filament organization [GO:0007015]; cellular homeostasis [GO:0019725]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrion organization [GO:0007005]; mitochondrion transport along microtubule [GO:0047497]; regulation of mitochondrion organization [GO:0010821]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.
Q8IXJ6	reviewed	SIR2_HUMAN	NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)	SIRT2 SIR2L SIR2L2	Homo sapiens (Human)	389	FUNCTION: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:24177535, PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20587414, PubMed:21081649, PubMed:20543840, PubMed:22014574, PubMed:21726808, PubMed:21949390, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24940000, PubMed:24769394, PubMed:24681946). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy (PubMed:24177535, PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20587414, PubMed:21081649, PubMed:20543840, PubMed:22014574, PubMed:21726808, PubMed:21949390, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24940000, PubMed:24769394, PubMed:24681946). Plays a major role in the control of cell cycle progression and genomic stability (PubMed:12697818, PubMed:17488717, PubMed:16909107, PubMed:17726514, PubMed:19282667, PubMed:23468428). Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes (PubMed:12697818, PubMed:17488717, PubMed:16909107, PubMed:17726514, PubMed:19282667, PubMed:23468428). Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis (PubMed:22014574). Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes (PubMed:23468428). Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis (PubMed:23468428). Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression (PubMed:23468428). Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response (PubMed:23468428). Deacetylates also histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition (PubMed:20587414). Upon bacterium Listeria monocytogenes infection, deacetylates 'Lys-18' of histone H3 in a receptor tyrosine kinase MET- and PI3K/Akt-dependent manner, thereby inhibiting transcriptional activity and promoting late stages of listeria infection (PubMed:23908241). During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function (PubMed:24940000). Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter and thereby contributes to regulate expression of VEGFA, a key regulator of angiogenesis (PubMed:24940000). Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells (PubMed:18332217, PubMed:18995842). Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation (PubMed:17488717). Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination (PubMed:21949390). Involved in several cellular metabolic pathways (PubMed:20543840, PubMed:21726808, PubMed:24769394). Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability (PubMed:21726808). Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage (PubMed:24769394). Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis (PubMed:20543840). Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity (PubMed:20543840). Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells (PubMed:20543840). Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy (PubMed:20543840). Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation (By similarity). Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia (PubMed:24681946). Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation (PubMed:21081649). Inhibits transcriptional activation by deacetylating p53/TP53 and EP300 (PubMed:18249187, PubMed:18995842). Deacetylates also EIF5A (PubMed:22771473). Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions (PubMed:24769394). Plays a role as tumor suppressor (PubMed:22014574). In addition to protein deacetylase activity, also has activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as ARF6 and KRAS, thereby regulating their association with membranes (PubMed:25704306, PubMed:29239724, PubMed:32103017). {ECO:0000250|UniProtKB:Q8VDQ8, ECO:0000269|PubMed:12620231, ECO:0000269|PubMed:12697818, ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:16909107, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:17574768, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:18249187, ECO:0000269|PubMed:18332217, ECO:0000269|PubMed:18640115, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:19282667, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:20587414, ECO:0000269|PubMed:21081649, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:21949390, ECO:0000269|PubMed:22014574, ECO:0000269|PubMed:22771473, ECO:0000269|PubMed:22819792, ECO:0000269|PubMed:23468428, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:24177535, ECO:0000269|PubMed:24681946, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25704306, ECO:0000269|PubMed:29239724, ECO:0000269|PubMed:32103017}.; FUNCTION: [Isoform 1]: Deacetylates EP300, alpha-tubulin and histone H3 and H4. {ECO:0000269|PubMed:24177535}.; FUNCTION: [Isoform 2]: Deacetylates EP300, alpha-tubulin and histone H3 and H4. {ECO:0000269|PubMed:24177535}.; FUNCTION: [Isoform 5]: Lacks deacetylation activity, at least toward known SIRT2 targets. {ECO:0000269|PubMed:24177535}.		autophagy [GO:0006914]; cell division [GO:0051301]; cellular lipid catabolic process [GO:0044242]; cellular response to caloric restriction [GO:0061433]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; epigenetic regulation of gene expression [GO:0040029]; heterochromatin formation [GO:0031507]; histone deacetylation [GO:0016575]; innate immune response [GO:0045087]; meiotic cell cycle [GO:0051321]; mitotic nuclear membrane reassembly [GO:0007084]; myelination in peripheral nervous system [GO:0022011]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of oligodendrocyte progenitor proliferation [GO:0070446]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; NLRP3 inflammasome complex assembly [GO:0044546]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of cell division [GO:0051781]; positive regulation of DNA binding [GO:0043388]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of oocyte maturation [GO:1900195]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [GO:2000777]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deacetylation [GO:0006476]; rDNA heterochromatin formation [GO:0000183]; regulation of cell cycle [GO:0051726]; regulation of exit from mitosis [GO:0007096]; regulation of myelination [GO:0031641]; regulation of phosphorylation [GO:0042325]; response to redox state [GO:0051775]; substantia nigra development [GO:0021762]; subtelomeric heterochromatin formation [GO:0031509]; tubulin deacetylation [GO:0090042]	centriole [GO:0005814]; centrosome [GO:0005813]; chromatin silencing complex [GO:0005677]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cell projection [GO:0097386]; growth cone [GO:0030426]; heterochromatin [GO:0000792]; juxtaparanode region of axon [GO:0044224]; lateral loop [GO:0043219]; meiotic spindle [GO:0072687]; microtubule [GO:0005874]; midbody [GO:0030496]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; myelin sheath [GO:0043209]; nucleolus [GO:0005730]; nucleus [GO:0005634]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220]; spindle [GO:0005819]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase binding [GO:0035035]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD-dependent histone deacetylase activity [GO:0017136]; NAD-dependent histone H4K16 deacetylase activity [GO:0046970]; NAD-dependent protein deacetylase activity [GO:0034979]; NAD-dependent protein demyristoylase activity [GO:0140773]; NAD-dependent protein depalmitoylase activity [GO:0140774]; protein lysine deacetylase activity [GO:0033558]; tubulin deacetylase activity [GO:0042903]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]	centriole [GO:0005814]; centrosome [GO:0005813]; chromatin silencing complex [GO:0005677]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cell projection [GO:0097386]; growth cone [GO:0030426]; heterochromatin [GO:0000792]; juxtaparanode region of axon [GO:0044224]; lateral loop [GO:0043219]; meiotic spindle [GO:0072687]; microtubule [GO:0005874]; midbody [GO:0030496]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; myelin sheath [GO:0043209]; nucleolus [GO:0005730]; nucleus [GO:0005634]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220]; spindle [GO:0005819]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase binding [GO:0035035]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD-dependent histone deacetylase activity [GO:0017136]; NAD-dependent histone H4K16 deacetylase activity [GO:0046970]; NAD-dependent protein deacetylase activity [GO:0034979]; NAD-dependent protein demyristoylase activity [GO:0140773]; NAD-dependent protein depalmitoylase activity [GO:0140774]; protein lysine deacetylase activity [GO:0033558]; tubulin deacetylase activity [GO:0042903]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]; autophagy [GO:0006914]; cell division [GO:0051301]; cellular lipid catabolic process [GO:0044242]; cellular response to caloric restriction [GO:0061433]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; epigenetic regulation of gene expression [GO:0040029]; heterochromatin formation [GO:0031507]; histone deacetylation [GO:0016575]; innate immune response [GO:0045087]; meiotic cell cycle [GO:0051321]; mitotic nuclear membrane reassembly [GO:0007084]; myelination in peripheral nervous system [GO:0022011]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of oligodendrocyte progenitor proliferation [GO:0070446]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; NLRP3 inflammasome complex assembly [GO:0044546]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of cell division [GO:0051781]; positive regulation of DNA binding [GO:0043388]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of oocyte maturation [GO:1900195]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [GO:2000777]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deacetylation [GO:0006476]; rDNA heterochromatin formation [GO:0000183]; regulation of cell cycle [GO:0051726]; regulation of exit from mitosis [GO:0007096]; regulation of myelination [GO:0031641]; regulation of phosphorylation [GO:0042325]; response to redox state [GO:0051775]; substantia nigra development [GO:0021762]; subtelomeric heterochromatin formation [GO:0031509]; tubulin deacetylation [GO:0090042]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12697818, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:24177535}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8VDQ8}. Cytoplasm {ECO:0000269|PubMed:12697818, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:24681946}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12620231}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:17726514}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:17726514}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17488717}. Midbody {ECO:0000269|PubMed:17726514}. Chromosome {ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:23468428}. Perikaryon {ECO:0000250|UniProtKB:Q8VDQ8}. Cell projection {ECO:0000250|UniProtKB:Q8VDQ8}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q8VDQ8}. Myelin membrane {ECO:0000250|UniProtKB:Q8VDQ8}. Note=Localizes in the cytoplasm during most of the cell cycle except in the G2/M transition and during mitosis, where it is localized in association with chromatin and induces deacetylation of histone at 'Lys-16' (H4K16ac) (PubMed:17726514, PubMed:23468428). Colocalizes with KMT5A at mitotic foci (PubMed:23468428). Colocalizes with CDK1 at centrosome during prophase and splindle fibers during metaphase (PubMed:17488717). Colocalizes with Aurora kinase AURKA at centrosome during early prophase and in the centrioles and growing mitotic spindle throughout metaphase (PubMed:17488717). Colocalizes with Aurora kinase AURKB during cytokinesis with the midbody (PubMed:17488717). Colocalizes with microtubules (PubMed:12620231). Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (By similarity). Shuttles between the cytoplasm and the nucleus through the CRM1 export pathway (PubMed:17726514). Colocalizes with EP300 in the nucleus (PubMed:24177535). Translocates to the nucleus and chromatin upon bacterium Listeria monocytogenes infection in interphase cells (PubMed:23908241). Deacetylates FOXO3 in the cytoplasm (By similarity). Colocalizes with PLP1 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheath (By similarity). Colocalizes with CDK5R1 in the perikaryon, neurites and growth cone of hippocampal neurons (By similarity). Colocalizes with alpha-tubulin in neuronal growth cone (By similarity). Localizes in the cytoplasm and nucleus of germinal vesicle (GV) stage oocytes (By similarity). Colocalizes with alpha-tubulin on the meiotic spindle as the oocytes enter into metaphase, and also during meiotic anaphase and telophase, especially with the midbody (By similarity). Colocalizes with PARD3 in internodal region of axons (By similarity). Colocalizes with acetylated alpha-tubulin in cell projection processes during primary oligodendrocyte precursor (OLP) differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VDQ8, ECO:0000269|PubMed:12620231, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:23468428, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:24177535}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the cytoplasmic. {ECO:0000269|PubMed:24177535}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the cytoplasmic. {ECO:0000269|PubMed:24177535}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the nucleus. {ECO:0000269|PubMed:24177535}.
Q8IXJ9	reviewed	ASXL1_HUMAN	Polycomb group protein ASXL1 (Additional sex combs-like protein 1)	ASXL1 KIAA0978	Homo sapiens (Human)	1541	FUNCTION: Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). {ECO:0000250|UniProtKB:P59598, ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:30982744}.		animal organ morphogenesis [GO:0009887]; bone marrow development [GO:0048539]; cell morphogenesis [GO:0000902]; chromatin organization [GO:0006325]; heart morphogenesis [GO:0003007]; hemopoiesis [GO:0030097]; homeostasis of number of cells [GO:0048872]; lung saccule development [GO:0060430]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; podocyte development [GO:0072015]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of kidney size [GO:0035564]; response to retinoic acid [GO:0032526]; thymus development [GO:0048538]	nucleoplasm [GO:0005654]; PR-DUB complex [GO:0035517]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear retinoic acid receptor binding [GO:0042974]; peroxisome proliferator activated receptor binding [GO:0042975]; transcription coactivator activity [GO:0003713]	nucleoplasm [GO:0005654]; PR-DUB complex [GO:0035517]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear retinoic acid receptor binding [GO:0042974]; peroxisome proliferator activated receptor binding [GO:0042975]; transcription coactivator activity [GO:0003713]; animal organ morphogenesis [GO:0009887]; bone marrow development [GO:0048539]; cell morphogenesis [GO:0000902]; chromatin organization [GO:0006325]; heart morphogenesis [GO:0003007]; hemopoiesis [GO:0030097]; homeostasis of number of cells [GO:0048872]; lung saccule development [GO:0060430]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; podocyte development [GO:0072015]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of kidney size [GO:0035564]; response to retinoic acid [GO:0032526]; thymus development [GO:0048538]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IXK0	reviewed	PHC2_HUMAN	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)	PHC2 EDR2 PH2	Homo sapiens (Human)	858	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.	MISCELLANEOUS: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.	negative regulation of DNA-templated transcription [GO:0045892]; spermatogenesis [GO:0007283]	heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]	heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; negative regulation of DNA-templated transcription [GO:0045892]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530}.
Q8IXK2	reviewed	GLT12_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12)	GALNT12	Homo sapiens (Human)	581	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.		O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q8IXL6	reviewed	FA20C_HUMAN	Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi casein kinase) (Golgi-enriched fraction casein kinase) (GEF-CK)	FAM20C DMP4	Homo sapiens (Human)	584	FUNCTION: Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates ERO1A, enhancing its activity which is required to maintain endoplasmic reticulum redox homeostasis and for oxidative protein folding (PubMed:29858230, PubMed:34349020). During endoplasmic reticulum stress, phosphorylates P4HB/PDIA1 which induces a functional switch, causing P4HB to change from an oxidoreductase to a molecular chaperone (PubMed:32149426). This is critical to maintain ER proteostasis and reduce cell death under ER stress (PubMed:32149426). Phosphorylation of P4HB also promotes its interaction with ERN1, leading to reduced activity of ERN1, a key sensor for the endoplasmic reticulum unfolded protein response (PubMed:32149426). Required for osteoblast differentiation and mineralization (PubMed:34349020). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1/OPN (PubMed:22582013, PubMed:25789606, PubMed:34349020). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039). {ECO:0000269|PubMed:22582013, ECO:0000269|PubMed:23754375, ECO:0000269|PubMed:25789606, ECO:0000269|PubMed:26091039, ECO:0000269|PubMed:29858230, ECO:0000269|PubMed:32149426, ECO:0000269|PubMed:34349020}.		biomineral tissue development [GO:0031214]; dentinogenesis [GO:0097187]; enamel mineralization [GO:0070166]; odontoblast differentiation [GO:0071895]; osteoclast maturation [GO:0036179]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; post-translational protein modification [GO:0043687]; protein autophosphorylation [GO:0046777]; protein metabolic process [GO:0019538]; protein phosphorylation [GO:0006468]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; regulation of phosphorus metabolic process [GO:0051174]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; manganese ion binding [GO:0030145]; protease binding [GO:0002020]; protein kinase activity [GO:0004672]; protein self-association [GO:0043621]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; manganese ion binding [GO:0030145]; protease binding [GO:0002020]; protein kinase activity [GO:0004672]; protein self-association [GO:0043621]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; biomineral tissue development [GO:0031214]; dentinogenesis [GO:0097187]; enamel mineralization [GO:0070166]; odontoblast differentiation [GO:0071895]; osteoclast maturation [GO:0036179]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; post-translational protein modification [GO:0043687]; protein autophosphorylation [GO:0046777]; protein metabolic process [GO:0019538]; protein phosphorylation [GO:0006468]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; regulation of phosphorus metabolic process [GO:0051174]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:32149426, ECO:0000269|PubMed:34349020}; Single-pass type II membrane protein {ECO:0000269|PubMed:34349020}. Secreted {ECO:0000269|PubMed:26091039}. Endoplasmic reticulum {ECO:0000269|PubMed:32149426}. Note=Resides in the Golgi apparatus membrane and is secreted following propeptide cleavage (PubMed:34349020). Retained in the endoplasmic reticulum (ER) in response to ER stress where it phosphorylates P4HB (PubMed:32149426). {ECO:0000269|PubMed:32149426, ECO:0000269|PubMed:34349020}.
Q8IXL7	reviewed	MSRB3_HUMAN	Methionine-R-sulfoxide reductase B3 (MsrB3) (EC 1.8.4.12) (EC 1.8.4.14)	MSRB3 UNQ1965/PRO4487	Homo sapiens (Human)	192	FUNCTION: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing. {ECO:0000269|PubMed:14699060, ECO:0000269|PubMed:21185009}.	MISCELLANEOUS: [Isoform 2]: Has a transit peptide. {ECO:0000305}.	protein repair [GO:0030091]; response to oxidative stress [GO:0006979]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]	L-methionine-(R)-S-oxide reductase activity [GO:0033745]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; L-methionine-(R)-S-oxide reductase activity [GO:0033745]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; zinc ion binding [GO:0008270]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion.
Q8IXM2	reviewed	BAP18_HUMAN	Chromatin complexes subunit BAP18 (BPTF-associated protein of 18 kDa)	BAP18 C17orf49	Homo sapiens (Human)	172	FUNCTION: Component of chromatin complexes such as the MLL1/MLL and NURF complexes.		chromatin organization [GO:0006325]	cytosol [GO:0005829]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; NURF complex [GO:0016589]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; NURF complex [GO:0016589]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; chromatin organization [GO:0006325]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IXM3	reviewed	RM41_HUMAN	Large ribosomal subunit protein mL41 (39S ribosomal protein L41, mitochondrial) (L41mt) (MRP-L41) (Bcl-2-interacting mitochondrial ribosomal protein L41) (Cell proliferation-inducing gene 3 protein) (MRP-L27 homolog)	MRPL41 BMRP MRPL27 RPML27 PIG3	Homo sapiens (Human)	137	FUNCTION: Component of the mitochondrial ribosome large subunit (PubMed:28892042, PubMed:25838379, PubMed:25278503). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796). {ECO:0000269|PubMed:16024796, ECO:0000269|PubMed:16256947, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16024796, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q8IXM6	reviewed	NRM_HUMAN	Nurim (Nuclear envelope membrane protein) (Nuclear rim protein)	NRM NRM29 UNQ555/PRO1112	Homo sapiens (Human)	262				membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]		membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:10402458, ECO:0000269|PubMed:15542857, ECO:0000269|PubMed:23092226}; Multi-pass membrane protein {ECO:0000269|PubMed:10402458, ECO:0000269|PubMed:15542857, ECO:0000269|PubMed:23092226}.
Q8IXN7	reviewed	RIMKA_HUMAN	N-acetylaspartylglutamate synthase A (NAAG synthetase A) (NAAGS) (EC 6.3.2.41) (N-acetylaspartylglutamylglutamate synthase A) (EC 6.3.2.42) (Ribosomal protein S6 modification-like protein A)	RIMKLA FAM80A	Homo sapiens (Human)	391	FUNCTION: Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate. {ECO:0000250|UniProtKB:Q6PFX8}.	MISCELLANEOUS: N-acetyl-L-aspartyl-L-glutamate (NAAG) is the most abundant dipeptide present in vertebrate central nervous system (CNS). {ECO:0000250|UniProtKB:Q6PFX8}.	glutamine family amino acid metabolic process [GO:0009064]; protein modification process [GO:0036211]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; N-acetyl-L-aspartate-L-glutamate ligase activity [GO:0072590]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; N-acetyl-L-aspartate-L-glutamate ligase activity [GO:0072590]; glutamine family amino acid metabolic process [GO:0009064]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8IXP5	reviewed	OCAT1_HUMAN	POU domain class 2-associating factor 2 (Oct coactivator from tuft cells 1) (Protein OCA-T1) (POU class 2 homeobox-associating factor 2)	POU2AF2 C11orf53	Homo sapiens (Human)	288	FUNCTION: Transcriptional coactivator of POU2F3 (PubMed:35576971, PubMed:36197978). This complex drives the development of tuft cells, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971). {ECO:0000269|PubMed:35576971, ECO:0000269|PubMed:36197978}.			cytosol [GO:0005829]; nucleus [GO:0005634]	POU domain binding [GO:0070974]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; nucleus [GO:0005634]; POU domain binding [GO:0070974]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:36197978}. Nucleus {ECO:0000269|PubMed:35576971, ECO:0000269|PubMed:36197978}. Note=Recruited to chromatin by POU2F3. {ECO:0000269|PubMed:36197978}.
Q8IXQ5	reviewed	KLHL7_HUMAN	Kelch-like protein 7	KLHL7	Homo sapiens (Human)	586	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. {ECO:0000269|PubMed:21828050}.		protein ubiquitination [GO:0016567]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16918702}. Cytoplasm {ECO:0000269|PubMed:27392078}. Note=Colocalizes with CUL3 in punctate structures at the perinuclear region of the cytoplasm. {ECO:0000269|PubMed:27392078}.
Q8IXQ6	reviewed	PARP9_HUMAN	Protein mono-ADP-ribosyltransferase PARP9 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein) (Poly [ADP-ribose] polymerase 9) (PARP-9)	PARP9 BAL BAL1	Homo sapiens (Human)	854	FUNCTION: ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (PubMed:28525742). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (PubMed:28525742). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (PubMed:23230272). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity (PubMed:28525742). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (By similarity). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP-ribosylation (PubMed:27796300). {ECO:0000250|UniProtKB:Q8CAS9, ECO:0000269|PubMed:16809771, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:27796300, ECO:0000269|PubMed:28525742}.		cell migration [GO:0016477]; defense response to virus [GO:0051607]; DNA damage checkpoint signaling [GO:0000077]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of catalytic activity [GO:0043086]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of response to type II interferon [GO:0060330]; viral protein processing [GO:0019082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734]	ADP-D-ribose binding [GO:0072570]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity [GO:0140802]; nucleotidyltransferase activity [GO:0016779]; STAT family protein binding [GO:0097677]; transcription corepressor activity [GO:0003714]; ubiquitin-like protein ligase binding [GO:0044389]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734]; ADP-D-ribose binding [GO:0072570]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity [GO:0140802]; nucleotidyltransferase activity [GO:0016779]; STAT family protein binding [GO:0097677]; transcription corepressor activity [GO:0003714]; ubiquitin-like protein ligase binding [GO:0044389]; cell migration [GO:0016477]; defense response to virus [GO:0051607]; DNA damage checkpoint signaling [GO:0000077]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of catalytic activity [GO:0043086]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of response to type II interferon [GO:0060330]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16809771, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:27796300}. Nucleus {ECO:0000269|PubMed:11110709, ECO:0000269|PubMed:16809771, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}. Note=Shuttles between the nucleus and the cytosol (PubMed:16809771). Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788). Export to the cytosol depends on the interaction with DTX3L (PubMed:16809771). Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272, PubMed:28525742). {ECO:0000269|PubMed:16809771, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}.
Q8IXQ9	reviewed	ETKMT_HUMAN	Electron transfer flavoprotein beta subunit lysine methyltransferase (EC 2.1.1.-) (ETFB lysine methyltransferase) (ETFB-KMT) (Protein N-lysine methyltransferase METTL20)	ETFBKMT C12orf72 METTL20	Homo sapiens (Human)	262	FUNCTION: Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria (PubMed:25023281, PubMed:25416781). Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain (PubMed:25416781). {ECO:0000269|PubMed:25023281, ECO:0000269|PubMed:25416781}.		negative regulation of electron transfer activity [GO:1904733]; negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:1904736]; peptidyl-lysine methylation [GO:0018022]; peptidyl-lysine trimethylation [GO:0018023]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; protein-containing complex [GO:0032991]	heat shock protein binding [GO:0031072]; protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; protein-containing complex [GO:0032991]; heat shock protein binding [GO:0031072]; protein-lysine N-methyltransferase activity [GO:0016279]; negative regulation of electron transfer activity [GO:1904733]; negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:1904736]; peptidyl-lysine methylation [GO:0018022]; peptidyl-lysine trimethylation [GO:0018023]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23349634}. Mitochondrion matrix {ECO:0000269|PubMed:25023281, ECO:0000305|PubMed:25416781}. Note=Concentrated in cytoplasmic granular foci. {ECO:0000269|PubMed:23349634}.
Q8IXS2	reviewed	DRC2_HUMAN	Dynein regulatory complex subunit 2 (Coiled-coil domain-containing protein 65) (Testis development protein NYD-SP28)	CCDC65 DRC2	Homo sapiens (Human)	484	FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:24094744). {ECO:0000250|UniProtKB:A8JB22, ECO:0000269|PubMed:24094744}.		axonemal dynein complex assembly [GO:0070286]; cilium assembly [GO:0060271]; cilium-dependent cell motility [GO:0060285]; regulation of cilium movement [GO:0003352]	axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514]		axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514]; axonemal dynein complex assembly [GO:0070286]; cilium assembly [GO:0060271]; cilium-dependent cell motility [GO:0060285]; regulation of cilium movement [GO:0003352]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250|UniProtKB:A8JB22}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A8JB22}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8JB22}.
Q8IXV7	reviewed	KLD8B_HUMAN	Kelch domain-containing protein 8B	KLHDC8B FP17659	Homo sapiens (Human)	354	FUNCTION: Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010). {ECO:0000269|PubMed:20107318, ECO:0000269|PubMed:22988245, ECO:0000269|PubMed:23713010}.		mitotic cytokinetic process [GO:1902410]; mitotic nuclear division [GO:0140014]; nuclear chromosome segregation [GO:0098813]	cellularization cleavage furrow [GO:0110070]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; midbody [GO:0030496]		cellularization cleavage furrow [GO:0110070]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; midbody [GO:0030496]; mitotic cytokinetic process [GO:1902410]; mitotic nuclear division [GO:0140014]; nuclear chromosome segregation [GO:0098813]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19706467, ECO:0000269|PubMed:20107318}. Midbody {ECO:0000269|PubMed:19706467, ECO:0000269|PubMed:20107318}. Note=In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis. {ECO:0000269|PubMed:19706467, ECO:0000269|PubMed:20107318}.
Q8IXW0	reviewed	LMTD2_HUMAN	Lamin tail domain-containing protein 2	LMNTD2 C11orf35	Homo sapiens (Human)	634				lamin filament [GO:0005638]	structural constituent of chromatin [GO:0030527]	lamin filament [GO:0005638]; structural constituent of chromatin [GO:0030527]	
Q8IXW5	reviewed	RPAP2_HUMAN	Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2)	RPAP2 C1orf82	Homo sapiens (Human)	612	FUNCTION: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580, ECO:0000269|PubMed:24997600, ECO:0000269|PubMed:30118681}.		snRNA transcription [GO:0009301]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase core enzyme binding [GO:0043175]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase core enzyme binding [GO:0043175]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; snRNA transcription [GO:0009301]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22137580}. Nucleus {ECO:0000269|PubMed:22137580}. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner.
Q8IXZ2	reviewed	ZC3H3_HUMAN	Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor)	ZC3H3 KIAA0150 SMICL ZC3HDC3	Homo sapiens (Human)	948	FUNCTION: Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity). {ECO:0000250|UniProtKB:Q8CHP0, ECO:0000269|PubMed:19364924}.		mRNA 3'-end processing [GO:0031124]; mRNA transport [GO:0051028]; positive regulation of activin receptor signaling pathway [GO:0032927]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; R-SMAD binding [GO:0070412]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; R-SMAD binding [GO:0070412]; mRNA 3'-end processing [GO:0031124]; mRNA transport [GO:0051028]; positive regulation of activin receptor signaling pathway [GO:0032927]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8CHP0}.
Q8IY17	reviewed	PLPL6_HUMAN	Patatin-like phospholipase domain-containing protein 6 (EC 3.1.1.5) (Neuropathy target esterase)	PNPLA6 NTE	Homo sapiens (Human)	1375	FUNCTION: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids (PubMed:11927584). Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (PubMed:11927584). {ECO:0000269|PubMed:11927584, ECO:0000269|PubMed:15044461}.	MISCELLANEOUS: Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. {ECO:0000303|PubMed:1666291}.	glycerophospholipid catabolic process [GO:0046475]; phosphatidylcholine metabolic process [GO:0046470]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; glycerophospholipid catabolic process [GO:0046475]; phosphatidylcholine metabolic process [GO:0046470]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15044461}; Single-pass type III membrane protein {ECO:0000269|PubMed:15044461}.
Q8IY18	reviewed	SMC5_HUMAN	Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)	SMC5 KIAA0594 SMC5L1	Homo sapiens (Human)	1101	FUNCTION: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}.		cell division [GO:0051301]; cellular senescence [GO:0090398]; chromatin looping [GO:0140588]; chromosome condensation [GO:0030261]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; mitotic cell cycle phase transition [GO:0044772]; negative regulation by host of viral genome replication [GO:0044828]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; protein localization to chromosome, centromeric region [GO:0071459]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]; stem cell population maintenance [GO:0019827]; telomere maintenance via recombination [GO:0000722]	cell junction [GO:0030054]; chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; interchromatin granule [GO:0035061]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; sex chromosome [GO:0000803]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA secondary structure binding [GO:0000217]; single-stranded DNA binding [GO:0003697]	cell junction [GO:0030054]; chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; interchromatin granule [GO:0035061]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; sex chromosome [GO:0000803]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA secondary structure binding [GO:0000217]; single-stranded DNA binding [GO:0003697]; cell division [GO:0051301]; cellular senescence [GO:0090398]; chromatin looping [GO:0140588]; chromosome condensation [GO:0030261]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; mitotic cell cycle phase transition [GO:0044772]; negative regulation by host of viral genome replication [GO:0044828]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; protein localization to chromosome, centromeric region [GO:0071459]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]; stem cell population maintenance [GO:0019827]; telomere maintenance via recombination [GO:0000722]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11408570, ECO:0000269|PubMed:25931565}. Chromosome {ECO:0000250|UniProtKB:Q8CG46}. Nucleus, PML body {ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:36373674}. Chromosome, telomere {ECO:0000269|PubMed:17589526}. Note=Associates with chromatin (PubMed:25931565). Colocalizes with SMC6 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity). Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526). Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). {ECO:0000250|UniProtKB:Q8CG46, ECO:0000269|PubMed:25931565}.
Q8IY21	reviewed	DDX60_HUMAN	Probable ATP-dependent RNA helicase DDX60 (EC 3.6.4.13) (DEAD box protein 60)	DDX60	Homo sapiens (Human)	1712	FUNCTION: Positively regulates RIGI- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of RIGI to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). {ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:21791617}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21791617}.
Q8IY22	reviewed	CMIP_HUMAN	C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip)	CMIP KIAA1694 TCMIP	Homo sapiens (Human)	773	FUNCTION: Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. {ECO:0000269|PubMed:12939343, ECO:0000269|PubMed:15128042}.		in utero embryonic development [GO:0001701]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; in utero embryonic development [GO:0001701]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12939343}. Cytoplasm {ECO:0000269|PubMed:12939343}. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343) (PubMed:15616553). Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343) (PubMed:15616553). Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343). {ECO:0000269|PubMed:12939343, ECO:0000269|PubMed:15616553}.
Q8IY26	reviewed	PLPP6_HUMAN	Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase)	PLPP6 PDP1 PPAPDC2	Homo sapiens (Human)	295	FUNCTION: Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates (PubMed:16464866, PubMed:19220020, PubMed:20110354). Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation (PubMed:16464866, PubMed:23568778). May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway (PubMed:20110354). May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins (PubMed:20110354). Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols (PubMed:18930839). May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate (PubMed:18930839, PubMed:20110354). {ECO:0000269|PubMed:16464866, ECO:0000269|PubMed:18930839, ECO:0000269|PubMed:19220020, ECO:0000269|PubMed:20110354, ECO:0000269|PubMed:23568778}.		cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate catabolic process [GO:0045339]; geranyl diphosphate metabolic process [GO:0033383]; geranylgeranyl diphosphate catabolic process [GO:1902247]; innate immune response [GO:0045087]; isoprenoid metabolic process [GO:0006720]; phospholipid dephosphorylation [GO:0046839]; positive regulation of neutrophil activation [GO:1902565]; protein prenylation [GO:0018342]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	hydrolase activity [GO:0016787]; isoprenoid diphosphate phosphatase activity [GO:0106405]; lipid phosphatase activity [GO:0042577]; lyase activity [GO:0016829]; lysophosphatidic acid phosphatase activity [GO:0052642]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; hydrolase activity [GO:0016787]; isoprenoid diphosphate phosphatase activity [GO:0106405]; lipid phosphatase activity [GO:0042577]; lyase activity [GO:0016829]; lysophosphatidic acid phosphatase activity [GO:0052642]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392]; cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate catabolic process [GO:0045339]; geranyl diphosphate metabolic process [GO:0033383]; geranylgeranyl diphosphate catabolic process [GO:1902247]; innate immune response [GO:0045087]; isoprenoid metabolic process [GO:0006720]; phospholipid dephosphorylation [GO:0046839]; positive regulation of neutrophil activation [GO:1902565]; protein prenylation [GO:0018342]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16464866, ECO:0000269|PubMed:18930839, ECO:0000269|PubMed:20110354}; Multi-pass membrane protein {ECO:0000305|PubMed:20110354}. Nucleus envelope {ECO:0000269|PubMed:18930839}. Nucleus inner membrane {ECO:0000305|PubMed:20110354}.
Q8IY31	reviewed	IFT20_HUMAN	Intraflagellar transport protein 20 homolog (hIFT20)	IFT20	Homo sapiens (Human)	132	FUNCTION: Part of intraflagellar transport (IFT) particles involved in ciliary process assembly (PubMed:17604723). May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004). Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719). Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (By similarity). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity). {ECO:0000250|UniProtKB:Q61025, ECO:0000269|PubMed:16775004, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:29237719}.		cardiac muscle cell differentiation [GO:0055007]; centrosome localization [GO:0051642]; cilium assembly [GO:0060271]; cochlea development [GO:0090102]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; inner ear receptor cell stereocilium organization [GO:0060122]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; neural precursor cell proliferation [GO:0061351]; opsin transport [GO:0036372]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of cilium assembly [GO:0045724]; protein localization to cilium [GO:0061512]; protein localization to Golgi apparatus [GO:0034067]; protein localization to plasma membrane [GO:0072659]; regulation of autophagosome assembly [GO:2000785]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cilium assembly [GO:1902017]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]; visual learning [GO:0008542]	acrosomal vesicle [GO:0001669]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; dendrite terminus [GO:0044292]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intraciliary transport particle B [GO:0030992]; kinociliary basal body [GO:1902636]; manchette [GO:0002177]; microvillus [GO:0005902]; motile cilium [GO:0031514]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; stereocilium [GO:0032420]	opsin binding [GO:0002046]; small GTPase binding [GO:0031267]	acrosomal vesicle [GO:0001669]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; dendrite terminus [GO:0044292]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intraciliary transport particle B [GO:0030992]; kinociliary basal body [GO:1902636]; manchette [GO:0002177]; microvillus [GO:0005902]; motile cilium [GO:0031514]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; stereocilium [GO:0032420]; opsin binding [GO:0002046]; small GTPase binding [GO:0031267]; cardiac muscle cell differentiation [GO:0055007]; centrosome localization [GO:0051642]; cilium assembly [GO:0060271]; cochlea development [GO:0090102]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; inner ear receptor cell stereocilium organization [GO:0060122]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; neural precursor cell proliferation [GO:0061351]; opsin transport [GO:0036372]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of cilium assembly [GO:0045724]; protein localization to cilium [GO:0061512]; protein localization to Golgi apparatus [GO:0034067]; protein localization to plasma membrane [GO:0072659]; regulation of autophagosome assembly [GO:2000785]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cilium assembly [GO:1902017]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q61025}. Cell projection, cilium {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q61025}. Golgi apparatus {ECO:0000250|UniProtKB:Q61025}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q61025}. Cytoplasm {ECO:0000250|UniProtKB:Q61025}. Note=Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole. Associated with basal body at the base of primary cilia. Detected in the Golgi apparatus of round spermatids and late spermatocytes. Also detected in the manchette of step 10-12 spermatids. In step 14 spermatids, found in the basal body of the sperm tail. Localization in the manchette of elongating spermatids is dependent on SPAG17. {ECO:0000250|UniProtKB:Q61025}.
Q8IY33	reviewed	MILK2_HUMAN	MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)	MICALL2 JRAB	Homo sapiens (Human)	904	FUNCTION: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). {ECO:0000250}.		actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; bicellular tight junction assembly [GO:0070830]; endocytic recycling [GO:0032456]; neuron projection development [GO:0031175]; positive regulation of protein targeting to mitochondrion [GO:1903955]; substrate adhesion-dependent cell spreading [GO:0034446]	bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; stress fiber [GO:0001725]	actin filament binding [GO:0051015]; actinin binding [GO:0042805]; filamin binding [GO:0031005]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]	bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; stress fiber [GO:0001725]; actin filament binding [GO:0051015]; actinin binding [GO:0042805]; filamin binding [GO:0031005]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; bicellular tight junction assembly [GO:0070830]; endocytic recycling [GO:0032456]; neuron projection development [GO:0031175]; positive regulation of protein targeting to mitochondrion [GO:1903955]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Recycling endosome {ECO:0000250}. Cell projection {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
Q8IY34	reviewed	S15A3_HUMAN	Solute carrier family 15 member 3 (Osteoclast transporter) (Peptide transporter 3) (Peptide/histidine transporter 2) (hPHT2)	SLC15A3 OCTP PHT2 PTR3	Homo sapiens (Human)	581	FUNCTION: Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine (PubMed:31073693, PubMed:31254495). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). {ECO:0000250|UniProtKB:Q8BPX9, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:31254495}.		dipeptide import across plasma membrane [GO:0140206]; innate immune response [GO:0045087]; monoatomic ion transport [GO:0006811]; peptidoglycan transport [GO:0015835]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; protein transport [GO:0015031]	endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]	dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; peptidoglycan transmembrane transporter activity [GO:0015647]	endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; peptidoglycan transmembrane transporter activity [GO:0015647]; dipeptide import across plasma membrane [GO:0140206]; innate immune response [GO:0045087]; monoatomic ion transport [GO:0006811]; peptidoglycan transport [GO:0015835]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q8BPX9}; Multi-pass membrane protein {ECO:0000255}.
Q8IY37	reviewed	DHX37_HUMAN	Probable ATP-dependent RNA helicase DHX37 (EC 3.6.4.13) (DEAH box protein 37)	DHX37 DDX37 KIAA1517	Homo sapiens (Human)	1157	FUNCTION: ATP-binding RNA helicase that plays a role in maturation of the small ribosomal subunit in ribosome biogenesis (PubMed:30582406). Required for the release of the U3 snoRNP from pre-ribosomal particles (PubMed:30582406). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Plays a role in early testis development (PubMed:31287541, PubMed:31337883). Probably also plays a role in brain development (PubMed:31256877). {ECO:0000269|PubMed:30582406, ECO:0000269|PubMed:31256877, ECO:0000269|PubMed:31287541, ECO:0000269|PubMed:31337883, ECO:0000269|PubMed:34516797}.		brain development [GO:0007420]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of male gonad development [GO:2000020]; ribosomal small subunit biogenesis [GO:0042274]; ribosome assembly [GO:0042255]; ribosome biogenesis [GO:0042254]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; U3 snoRNA binding [GO:0034511]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; U3 snoRNA binding [GO:0034511]; brain development [GO:0007420]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of male gonad development [GO:2000020]; ribosomal small subunit biogenesis [GO:0042274]; ribosome assembly [GO:0042255]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:30582406, ECO:0000269|PubMed:31337883, ECO:0000269|PubMed:34516797}. Cytoplasm {ECO:0000269|PubMed:31337883}. Nucleus membrane {ECO:0000269|PubMed:31337883}.
Q8IY49	reviewed	PAQRA_HUMAN	Monocyte to macrophage differentiation factor 2 (Progestin and adipoQ receptor family member 10) (Progestin and adipoQ receptor family member X)	MMD2 PAQR10	Homo sapiens (Human)	270			positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of protein localization [GO:0032880]	Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]	protein kinase activity [GO:0004672]	Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; protein kinase activity [GO:0004672]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:22339580}; Multi-pass membrane protein {ECO:0000269|PubMed:22339580}.
Q8IY57	reviewed	YAF2_HUMAN	YY1-associated factor 2	YAF2	Homo sapiens (Human)	180	FUNCTION: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}.		negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11593398}.
Q8IY63	reviewed	AMOL1_HUMAN	Angiomotin-like protein 1	AMOTL1	Homo sapiens (Human)	956	FUNCTION: Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}.		actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; hippo signaling [GO:0035329]; regulation of cell migration [GO:0030334]; Wnt signaling pathway [GO:0016055]	bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; hippo signaling [GO:0035329]; regulation of cell migration [GO:0030334]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}.
Q8IY81	reviewed	SPB1_HUMAN	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3)	FTSJ3 SB92	Homo sapiens (Human)	847	FUNCTION: RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}.		maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; RNA methylation [GO:0001510]; rRNA methylation [GO:0031167]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]; preribosome, small subunit precursor [GO:0030688]	RNA 2'-O-methyltransferase activity [GO:0062105]; RNA binding [GO:0003723]; rRNA (guanine) methyltransferase activity [GO:0016435]; rRNA (uridine-2'-O-)-methyltransferase activity [GO:0008650]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]; preribosome, small subunit precursor [GO:0030688]; RNA 2'-O-methyltransferase activity [GO:0062105]; RNA binding [GO:0003723]; rRNA (guanine) methyltransferase activity [GO:0016435]; rRNA (uridine-2'-O-)-methyltransferase activity [GO:0008650]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; RNA methylation [GO:0001510]; rRNA methylation [GO:0031167]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:22195017}.
Q8IY82	reviewed	DRC7_HUMAN	Dynein regulatory complex subunit 7 (Coiled-coil domain-containing protein 135) (Coiled-coil domain-containing protein lobo homolog)	DRC7 C16orf50 CCDC135	Homo sapiens (Human)	874	FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Involved in the regulation of flagellar motility (By similarity). Essential for male fertility, sperm head morphogenesis and sperm flagellum formation (By similarity). {ECO:0000250|UniProtKB:A8JAM0, ECO:0000250|UniProtKB:Q6V3W6}.		flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A8JAM0}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A8JAM0}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8JAM0}. Note=Associated with the outer doublet microtubules (OD). {ECO:0000250|UniProtKB:A8JAM0}.
Q8IY84	reviewed	NIM1_HUMAN	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase)	NIM1K NIM1	Homo sapiens (Human)	436			intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]		ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]	
Q8IY92	reviewed	SLX4_HUMAN	Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)	SLX4 BTBD12 KIAA1784 KIAA1987	Homo sapiens (Human)	1834	FUNCTION: Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.		DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; nucleotide-excision repair [GO:0006289]; positive regulation of t-circle formation [GO:1904431]; positive regulation of telomere maintenance [GO:0032206]; resolution of meiotic recombination intermediates [GO:0000712]; response to intra-S DNA damage checkpoint signaling [GO:0072429]; t-circle formation [GO:0090656]; telomeric D-loop disassembly [GO:0061820]	cell junction [GO:0030054]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; Slx1-Slx4 complex [GO:0033557]	DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]	cell junction [GO:0030054]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; Slx1-Slx4 complex [GO:0033557]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; nucleotide-excision repair [GO:0006289]; positive regulation of t-circle formation [GO:1904431]; positive regulation of telomere maintenance [GO:0032206]; resolution of meiotic recombination intermediates [GO:0000712]; response to intra-S DNA damage checkpoint signaling [GO:0072429]; t-circle formation [GO:0090656]; telomeric D-loop disassembly [GO:0061820]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. Note=Localizes to sites of DNA damage.
Q8IY95	reviewed	TM192_HUMAN	Transmembrane protein 192	TMEM192	Homo sapiens (Human)	271				endosome [GO:0005768]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	protein homodimerization activity [GO:0042803]	endosome [GO:0005768]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein homodimerization activity [GO:0042803]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:20370317}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319}. Late endosome {ECO:0000269|PubMed:20370317}.
Q8IYA6	reviewed	CKP2L_HUMAN	Cytoskeleton-associated protein 2-like (Radial fiber and mitotic spindle protein) (Radmis)	CKAP2L	Homo sapiens (Human)	745	FUNCTION: Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells. {ECO:0000269|PubMed:25439729}.			centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]		centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:25439729}. Note=Uniformly distributed along each microtubule bundle of spindles in addition to centrioles during mitosis, expression promptly diminishes at interphase. {ECO:0000269|PubMed:25439729}.
Q8IYA8	reviewed	IHO1_HUMAN	Interactor of HORMAD1 protein 1 (Cancer/testis antigen 74) (CT74) (Coiled-coil domain-containing protein 36)	IHO1 CCDC36	Homo sapiens (Human)	594	FUNCTION: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. {ECO:0000250|UniProtKB:Q6PDM4}.		DNA recombination [GO:0006310]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break formation [GO:0042138]; oogenesis [GO:0048477]; regulation of homologous chromosome segregation [GO:0060629]; spermatogenesis [GO:0007283]	condensed nuclear chromosome [GO:0000794]		condensed nuclear chromosome [GO:0000794]; DNA recombination [GO:0006310]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break formation [GO:0042138]; oogenesis [GO:0048477]; regulation of homologous chromosome segregation [GO:0060629]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q6PDM4}. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis. {ECO:0000250|UniProtKB:Q6PDM4}.
Q8IYB1	reviewed	M21D2_HUMAN	Nucleotidyltransferase MB21D2 (EC 2.7.7.-) (Mab-21 domain-containing protein 2) (hMB21D2)	MB21D2 C3orf59	Homo sapiens (Human)	491	FUNCTION: Probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messenger in response to some unknown stimulus. {ECO:0000305|PubMed:34261127}.				cadherin binding [GO:0045296]; nucleotidyltransferase activity [GO:0016779]; protein-containing complex binding [GO:0044877]	cadherin binding [GO:0045296]; nucleotidyltransferase activity [GO:0016779]; protein-containing complex binding [GO:0044877]	
Q8IYB3	reviewed	SRRM1_HUMAN	Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)	SRRM1 SRM160	Homo sapiens (Human)	904	FUNCTION: Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.		localization [GO:0051179]; mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	DNA binding [GO:0003677]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; localization [GO:0051179]; mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:12624182, ECO:0000269|PubMed:9531537}. Nucleus speckle {ECO:0000269|PubMed:11546874, ECO:0000269|PubMed:9531537}.
Q8IYB4	reviewed	PEX5R_HUMAN	PEX5-related protein (PEX2-related protein) (PEX5-like protein) (Peroxin-5-related protein) (Peroxisome biogenesis factor 5-like) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b)	PEX5L PEX5R PXR2	Homo sapiens (Human)	626	FUNCTION: Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence. {ECO:0000250}.		protein import into peroxisome matrix, docking [GO:0016560]; regulation of cAMP-mediated signaling [GO:0043949]	cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; receptor complex [GO:0043235]	peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome targeting sequence binding [GO:0000268]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; receptor complex [GO:0043235]; peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome targeting sequence binding [GO:0000268]; small GTPase binding [GO:0031267]; protein import into peroxisome matrix, docking [GO:0016560]; regulation of cAMP-mediated signaling [GO:0043949]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Some fraction is membrane associated via its interaction with RAB8B. {ECO:0000250}.
Q8IYB5	reviewed	SMAP1_HUMAN	Stromal membrane-associated protein 1	SMAP1	Homo sapiens (Human)	467	FUNCTION: GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity). {ECO:0000250}.		positive regulation of erythrocyte differentiation [GO:0045648]; regulation of clathrin-dependent endocytosis [GO:2000369]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	clathrin binding [GO:0030276]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; clathrin binding [GO:0030276]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of clathrin-dependent endocytosis [GO:2000369]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Q8IYB7	reviewed	DI3L2_HUMAN	DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-)	DIS3L2 FAM6A	Homo sapiens (Human)	885	FUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell division [GO:0051301]; miRNA catabolic process [GO:0010587]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid separation [GO:0051306]; mRNA catabolic process [GO:0006402]; negative regulation of cell population proliferation [GO:0008285]; nuclear-transcribed mRNA catabolic process, exonucleolytic [GO:0000291]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; stem cell population maintenance [GO:0019827]	cytoplasm [GO:0005737]; P-body [GO:0000932]; polysome [GO:0005844]	3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; poly(U) RNA binding [GO:0008266]; RNA nuclease activity [GO:0004540]	cytoplasm [GO:0005737]; P-body [GO:0000932]; polysome [GO:0005844]; 3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; poly(U) RNA binding [GO:0008266]; RNA nuclease activity [GO:0004540]; cell division [GO:0051301]; miRNA catabolic process [GO:0010587]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid separation [GO:0051306]; mRNA catabolic process [GO:0006402]; negative regulation of cell population proliferation [GO:0008285]; nuclear-transcribed mRNA catabolic process, exonucleolytic [GO:0000291]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24141620}. Cytoplasm, P-body.
Q8IYB8	reviewed	SUV3_HUMAN	ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1)	SUPV3L1 SUV3	Homo sapiens (Human)	786	FUNCTION: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. {ECO:0000269|PubMed:12466530, ECO:0000269|PubMed:15096047, ECO:0000269|PubMed:17352692, ECO:0000269|PubMed:17961633, ECO:0000269|PubMed:18678873, ECO:0000269|PubMed:19509288, ECO:0000269|PubMed:19864255, ECO:0000269|PubMed:29967381}.		DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA surveillance [GO:0035946]; mitochondrial ncRNA surveillance [GO:0035945]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA surveillance [GO:2000827]; mitochondrion morphogenesis [GO:0070584]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell growth [GO:0030307]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; RNA catabolic process [GO:0006401]	mitochondrial degradosome [GO:0045025]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	mitochondrial degradosome [GO:0045025]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA surveillance [GO:0035946]; mitochondrial ncRNA surveillance [GO:0035945]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA surveillance [GO:2000827]; mitochondrion morphogenesis [GO:0070584]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell growth [GO:0030307]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; RNA catabolic process [GO:0006401]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17352692}. Mitochondrion matrix {ECO:0000269|PubMed:12466530, ECO:0000269|PubMed:17352692, ECO:0000269|PubMed:19864255}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.
Q8IYD1	reviewed	ERF3B_HUMAN	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog)	GSPT2 ERF3B	Homo sapiens (Human)	628	FUNCTION: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:11524954, PubMed:17562865). GSPT2/ERF3B mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:15987998). GTP hydrolysis by GSPT2/ERF3B induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:15987998). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). {ECO:0000269|PubMed:11524954, ECO:0000269|PubMed:15987998, ECO:0000269|PubMed:17562865, ECO:0000269|PubMed:19417104}.		cell cycle [GO:0007049]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; translation [GO:0006412]; translational termination [GO:0006415]	cytosol [GO:0005829]; translation release factor complex [GO:0018444]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation release factor activity [GO:0003747]	cytosol [GO:0005829]; translation release factor complex [GO:0018444]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation release factor activity [GO:0003747]; cell cycle [GO:0007049]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; translation [GO:0006412]; translational termination [GO:0006415]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8IYD8	reviewed	FANCM_HUMAN	Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog)	FANCM KIAA1596	Homo sapiens (Human)	2048	FUNCTION: DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}.		double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; interstrand cross-link repair [GO:0036297]; positive regulation of protein monoubiquitination [GO:1902527]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]	chromatin [GO:0000785]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; nuclease activity [GO:0004518]; RNA helicase activity [GO:0003724]	chromatin [GO:0000785]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; nuclease activity [GO:0004518]; RNA helicase activity [GO:0003724]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; interstrand cross-link repair [GO:0036297]; positive regulation of protein monoubiquitination [GO:1902527]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}.
Q8IYE0	reviewed	CC146_HUMAN	Coiled-coil domain-containing protein 146	CCDC146 KIAA1505	Homo sapiens (Human)	955				centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]		centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:25074808}. Note=Localized to only one centriole identified as the mother centriole by co-staining with CEP164. {ECO:0000269|PubMed:25074808}.
Q8IYE1	reviewed	CCD13_HUMAN	Coiled-coil domain-containing protein 13	CCDC13	Homo sapiens (Human)	715	FUNCTION: Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia. {ECO:0000269|PubMed:24816561}.		cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; non-motile cilium assembly [GO:1905515]	cell projection [GO:0042995]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cell projection [GO:0042995]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; non-motile cilium assembly [GO:1905515]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24816561}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24816561}.
Q8IYF1	reviewed	ELOA2_HUMAN	Elongin-A2 (EloA2) (RNA polymerase II transcription factor SIII subunit A2) (Transcription elongation factor B polypeptide 3B)	ELOA2 TCEB3B TCEB3L	Homo sapiens (Human)	753	FUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). {ECO:0000269|PubMed:10692460}.		regulation of DNA-templated transcription elongation [GO:0032784]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]	elongin complex [GO:0070449]; nucleoplasm [GO:0005654]		elongin complex [GO:0070449]; nucleoplasm [GO:0005654]; regulation of DNA-templated transcription elongation [GO:0032784]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IYF3	reviewed	TEX11_HUMAN	Testis-expressed protein 11 (Protein ZIP4 homolog) (ZIP4H)	TEX11 ZIP4	Homo sapiens (Human)	940	FUNCTION: Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. {ECO:0000250|UniProtKB:Q14AT2}.		apoptotic process [GO:0006915]; chiasma assembly [GO:0051026]; ectopic germ cell programmed cell death [GO:0035234]; fertilization [GO:0009566]; male gonad development [GO:0008584]; male meiosis chromosome segregation [GO:0007060]; meiotic gene conversion [GO:0006311]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of reproductive process [GO:2000242]; reciprocal meiotic recombination [GO:0007131]; resolution of meiotic recombination intermediates [GO:0000712]; synaptonemal complex assembly [GO:0007130]	central element [GO:0000801]; chromosome [GO:0005694]		central element [GO:0000801]; chromosome [GO:0005694]; apoptotic process [GO:0006915]; chiasma assembly [GO:0051026]; ectopic germ cell programmed cell death [GO:0035234]; fertilization [GO:0009566]; male gonad development [GO:0008584]; male meiosis chromosome segregation [GO:0007060]; meiotic gene conversion [GO:0006311]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of reproductive process [GO:2000242]; reciprocal meiotic recombination [GO:0007131]; resolution of meiotic recombination intermediates [GO:0000712]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q14AT2}. Note=Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes. {ECO:0000250|UniProtKB:Q14AT2}.
Q8IYG6	reviewed	LRC56_HUMAN	Leucine-rich repeat-containing protein 56	LRRC56	Homo sapiens (Human)	542	FUNCTION: Required for the assembly of dynein arms. {ECO:0000250|UniProtKB:Q387Y5}.		cell projection organization [GO:0030030]	cilium [GO:0005929]		cilium [GO:0005929]; cell projection organization [GO:0030030]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q387Y5}.
Q8IYH5	reviewed	ZZZ3_HUMAN	ZZ-type zinc finger-containing protein 3	ZZZ3	Homo sapiens (Human)	903	FUNCTION: Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}.		chromatin organization [GO:0006325]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Q8IYI0	reviewed	SHLD1_HUMAN	Shieldin complex subunit 1 (RINN1-REV7-interacting novel NHEJ regulator 3) (Shield complex subunit 1)	SHLD1 C20orf196 RINN3	Homo sapiens (Human)	205	FUNCTION: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. {ECO:0000269|PubMed:29656893}.	MISCELLANEOUS: In BRCA1-deficient cells, function of the shieldin complex is necessary for sensitivity to the PARP inhibitor olaparib. {ECO:0000269|PubMed:29656893}.	DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247]	chromatin [GO:0000785]; chromosome [GO:0005694]; site of double-strand break [GO:0035861]		chromatin [GO:0000785]; chromosome [GO:0005694]; site of double-strand break [GO:0035861]; DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:29656893}.
Q8IYI6	reviewed	EXOC8_HUMAN	Exocyst complex component 8 (Exocyst complex 84 kDa subunit)	EXOC8	Homo sapiens (Human)	725	FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.		endosome organization [GO:0007032]; exocytosis [GO:0006887]; extracellular matrix disassembly [GO:0022617]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	cell leading edge [GO:0031252]; cytosol [GO:0005829]; exocyst [GO:0000145]; growth cone [GO:0030426]; late endosome [GO:0005770]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]	cell leading edge [GO:0031252]; cytosol [GO:0005829]; exocyst [GO:0000145]; growth cone [GO:0030426]; late endosome [GO:0005770]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; endosome organization [GO:0007032]; exocytosis [GO:0006887]; extracellular matrix disassembly [GO:0022617]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54924}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54924}. Cell projection, growth cone {ECO:0000250|UniProtKB:O54924}. Cell projection {ECO:0000250|UniProtKB:O54924}. Note=Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Localizes at the leading edge of migrating cells (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O54924}.
Q8IYI8	reviewed	ZN440_HUMAN	Zinc finger protein 440	ZNF440	Homo sapiens (Human)	595	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IYJ0	reviewed	PIANP_HUMAN	PILR alpha-associated neural protein (PILR-associating neural protein) (Paired immunoglobin-like type 2 receptor-associating neural protein)	PIANP C12orf53 PANP UNQ828/PRO1755	Homo sapiens (Human)	282	FUNCTION: Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation. {ECO:0000269|PubMed:21241660}.		regulation of immune response [GO:0050776]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]		basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8IYJ1	reviewed	CPNE9_HUMAN	Copine-9 (Copine IX)	CPNE9	Homo sapiens (Human)	553	FUNCTION: Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99829, ECO:0000269|PubMed:23999003}.		cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]	
Q8IYJ2	reviewed	CJ067_HUMAN	Uncharacterized protein C10orf67, mitochondrial	C10orf67 LINC01552	Homo sapiens (Human)	551				mitochondrion [GO:0005739]		mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255}.
Q8IYJ3	reviewed	SYTL1_HUMAN	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1)	SYTL1 SLP1 SB146	Homo sapiens (Human)	562	FUNCTION: May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}.		exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]	exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	neurexin family protein binding [GO:0042043]; small GTPase binding [GO:0031267]	exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; neurexin family protein binding [GO:0042043]; small GTPase binding [GO:0031267]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}; Peripheral membrane protein {ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}; Cytoplasmic side {ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}. Note=Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes.
Q8IYK4	reviewed	GT252_HUMAN	Procollagen galactosyltransferase 2 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 2) (ColGalT 2) (Glycosyltransferase 25 family member 2) (Hydroxylysine galactosyltransferase 2)	COLGALT2 C1orf17 GLT25D2 KIAA0584	Homo sapiens (Human)	626	FUNCTION: Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen. {ECO:0000269|PubMed:19075007}.		collagen fibril organization [GO:0030199]	endoplasmic reticulum lumen [GO:0005788]	procollagen galactosyltransferase activity [GO:0050211]	endoplasmic reticulum lumen [GO:0005788]; procollagen galactosyltransferase activity [GO:0050211]; collagen fibril organization [GO:0030199]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q8IYL9	reviewed	PSYR_HUMAN	Psychosine receptor (G-protein coupled receptor 65) (T-cell death-associated gene 8 protein)	GPR65 TDAG8	Homo sapiens (Human)	337	FUNCTION: Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity). {ECO:0000250|UniProtKB:Q61038, ECO:0000269|PubMed:11309421, ECO:0000269|PubMed:27287411}.		activation of GTPase activity [GO:0090630]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic process [GO:0006915]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; response to acidic pH [GO:0010447]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; activation of GTPase activity [GO:0090630]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic process [GO:0006915]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; response to acidic pH [GO:0010447]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q8IYM1	reviewed	SEP12_HUMAN	Septin-12	SEPTIN12 SEPT12	Homo sapiens (Human)	358	FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential). {ECO:0000250, ECO:0000269|PubMed:24213608, ECO:0000269|PubMed:25588830, ECO:0000305}.		cell differentiation [GO:0030154]; cytoskeleton-dependent cytokinesis [GO:0061640]; spermatogenesis [GO:0007283]	cell division site [GO:0032153]; cleavage furrow [GO:0032154]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; stress fiber [GO:0001725]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]	cell division site [GO:0032153]; cleavage furrow [GO:0032154]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; stress fiber [GO:0001725]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; cell differentiation [GO:0030154]; cytoskeleton-dependent cytokinesis [GO:0061640]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18047794}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18047794}. Nucleus {ECO:0000269|PubMed:25775403}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:22275165}. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus. Colocalized with SPAG4 at the nuclear periphery in round spermatids, at sperm neck in elongated spermatids and at midpiece regions in ejaculated spermatozoa. {ECO:0000269|PubMed:18047794, ECO:0000269|PubMed:20801438, ECO:0000269|PubMed:22275165, ECO:0000269|PubMed:25775403}.
Q8IYM2	reviewed	SLN12_HUMAN	Ribonuclease SLFN12 (EC 3.1.-.-) (Schlafen family member 12)	SLFN12	Homo sapiens (Human)	578	FUNCTION: Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:35104454, PubMed:34272366, PubMed:34707099). May play a role in cell differentiation (PubMed:30045019). {ECO:0000269|PubMed:30045019, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34272366, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:35104454}.		apoptotic signaling pathway [GO:0097190]; rRNA catabolic process [GO:0016075]	cytosol [GO:0005829]; nucleus [GO:0005634]	catalytic activity, acting on a rRNA [GO:0140102]; ribosome binding [GO:0043022]; RNA nuclease activity [GO:0004540]	cytosol [GO:0005829]; nucleus [GO:0005634]; catalytic activity, acting on a rRNA [GO:0140102]; ribosome binding [GO:0043022]; RNA nuclease activity [GO:0004540]; apoptotic signaling pathway [GO:0097190]; rRNA catabolic process [GO:0016075]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35104454}. Cytoplasm, cytosol {ECO:0000269|PubMed:35104454}.
Q8IYM9	reviewed	TRI22_HUMAN	E3 ubiquitin-protein ligase TRIM22 (EC 2.3.2.27) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (RING-type E3 ubiquitin transferase TRIM22) (Staf-50) (Tripartite motif-containing protein 22)	TRIM22 RNF94 STAF50	Homo sapiens (Human)	498	FUNCTION: Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity (PubMed:25683609, PubMed:35777501). Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV) (PubMed:25683609, PubMed:35777501, PubMed:36042495). Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A (PubMed:25683609). Acts also by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation (PubMed:36042495). Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter (PubMed:26683615). Plays also a role in antiviral immunity by co-regulating together with NT5C2 the RIGI/NF-kappa-B pathway by promoting 'Lys-63'-linked ubiquitination of RIGI, while NT5C2 is responsible for 'Lys-48'-linked ubiquitination of RIGI (PubMed:36159777). Participates in adaptive immunity by suppressing the amount of MHC class II protein in a negative feedback manner in order to limit the extent of MHC class II induction (PubMed:35777501). {ECO:0000269|PubMed:18389079, ECO:0000269|PubMed:18656448, ECO:0000269|PubMed:19218198, ECO:0000269|PubMed:19585648, ECO:0000269|PubMed:25683609, ECO:0000269|PubMed:26683615, ECO:0000269|PubMed:35777501, ECO:0000269|PubMed:36042495, ECO:0000269|PubMed:36159777}.		defense response to virus [GO:0051607]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein ubiquitination [GO:0016567]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to virus [GO:0009615]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; defense response to virus [GO:0051607]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein ubiquitination [GO:0016567]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:25683609}. Nucleus {ECO:0000269|PubMed:17156811}. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
Q8IYP9	reviewed	ZDH23_HUMAN	Palmitoyltransferase ZDHHC23 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 23) (DHHC-23) (zDHHC23)	ZDHHC23	Homo sapiens (Human)	409	FUNCTION: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. {ECO:0000269|PubMed:22399288, ECO:0000305|PubMed:22399288}.		protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:22399288}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305|PubMed:22399288}; Multi-pass membrane protein {ECO:0000255}.
Q8IYR0	reviewed	CF206_HUMAN	Cilia- and flagella-associated protein 206	CFAP206 C6orf165	Homo sapiens (Human)	622	FUNCTION: Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). Required for the establishment of radial spokes in sperm flagella (By similarity). {ECO:0000250|UniProtKB:Q6PE87}.		axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; regulation of cilium beat frequency [GO:0003356]; regulation of flagellated sperm motility [GO:1901317]; sperm axoneme assembly [GO:0007288]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514]; radial spoke [GO:0001534]		axoneme [GO:0005930]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; regulation of cilium beat frequency [GO:0003356]; regulation of flagellated sperm motility [GO:1901317]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q6PE87}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q6PE87}.
Q8IYR2	reviewed	SMYD4_HUMAN	SET and MYND domain-containing protein 4 (EC 2.1.1.-)	SMYD4 KIAA1936	Homo sapiens (Human)	804	FUNCTION: Plays a critical role in cardiac development (PubMed:30110327). Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (By similarity). {ECO:0000250|UniProtKB:Q08C84, ECO:0000269|PubMed:30110327}.		heart development [GO:0007507]; methylation [GO:0032259]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; heart development [GO:0007507]; methylation [GO:0032259]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BTK5}. Cytoplasm {ECO:0000250|UniProtKB:Q8BTK5}.
Q8IYR6	reviewed	TEFF1_HUMAN	Tomoregulin-1 (TR-1) (H7365) (Transmembrane protein with EGF-like and one follistatin-like domain)	TMEFF1 C9orf2	Homo sapiens (Human)	380	FUNCTION: May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers. {ECO:0000250, ECO:0000269|PubMed:12743596}.			plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12743596}; Single-pass type I membrane protein {ECO:0000269|PubMed:12743596}.
Q8IYS1	reviewed	P20D2_HUMAN	Xaa-Arg dipeptidase (EC 3.4.13.4) (Beta-Ala-Lys dipeptidase)	PM20D2 ACY1L2	Homo sapiens (Human)	436	FUNCTION: Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. Postulated to function in a metabolite repair mechanism by eliminating alternate dipeptide by-products formed during carnosine synthesis. {ECO:0000269|PubMed:24891507}.		proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246]	nucleoplasm [GO:0005654]	carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; identical protein binding [GO:0042802]	nucleoplasm [GO:0005654]; carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; identical protein binding [GO:0042802]; proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246]	
Q8IYS5	reviewed	OSCAR_HUMAN	Osteoclast-associated immunoglobulin-like receptor (Osteoclast-associated receptor) (hOSCAR) (Polymeric immunoglobulin receptor 3) (PIgR-3) (PIgR3) (Poly-Ig receptor 3)	OSCAR	Homo sapiens (Human)	282	FUNCTION: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. {ECO:0000250}.		osteoclast differentiation [GO:0030316]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	collagen receptor activity [GO:0038064]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; collagen receptor activity [GO:0038064]; osteoclast differentiation [GO:0030316]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8IYT2	reviewed	CMTR2_HUMAN	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296) (Cap methyltransferase 2) (Cap2 2'O-ribose methyltransferase 2) (HMTr2) (MTr2) (FtsJ methyltransferase domain-containing protein 1) (Protein adrift homolog)	CMTR2 AFT FTSJD1	Homo sapiens (Human)	770	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs. {ECO:0000269|PubMed:21310715}.		7-methylguanosine mRNA capping [GO:0006370]; cap1 mRNA methylation [GO:0097309]; cap2 mRNA methylation [GO:0097310]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483]; 7-methylguanosine mRNA capping [GO:0006370]; cap1 mRNA methylation [GO:0097309]; cap2 mRNA methylation [GO:0097310]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21310715}. Cytoplasm {ECO:0000269|PubMed:21310715}.
Q8IYT3	reviewed	CC170_HUMAN	Coiled-coil domain-containing protein 170	CCDC170 C6orf97	Homo sapiens (Human)	715	FUNCTION: Plays a role in Golgi-associated microtubules organization and stabilization. {ECO:0000269|PubMed:28687497}.		microtubule cytoskeleton organization [GO:0000226]	cell junction [GO:0030054]; ciliary basal body [GO:0036064]; Golgi apparatus [GO:0005794]	microtubule binding [GO:0008017]	cell junction [GO:0030054]; ciliary basal body [GO:0036064]; Golgi apparatus [GO:0005794]; microtubule binding [GO:0008017]; microtubule cytoskeleton organization [GO:0000226]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:28687497}.
Q8IYT4	reviewed	KATL2_HUMAN	Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 5.6.1.1) (p60 katanin-like 2)	KATNAL2	Homo sapiens (Human)	538	FUNCTION: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. {ECO:0000255|HAMAP-Rule:MF_03025}.		cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013]	cytoplasm [GO:0005737]; katanin complex [GO:0008352]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568]	cytoplasm [GO:0005737]; katanin complex [GO:0008352]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568]; cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03025}. Cytoplasm {ECO:0000269|PubMed:26929214}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26929214}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:26929214}. Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis. {ECO:0000269|PubMed:26929214}.
Q8IYT8	reviewed	ULK2_HUMAN	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2)	ULK2 KIAA0623	Homo sapiens (Human)	1036	FUNCTION: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635, ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; axon extension [GO:0048675]; collateral sprouting [GO:0048668]; late nucleophagy [GO:0044805]; negative regulation of collateral sprouting [GO:0048671]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; protein autophosphorylation [GO:0046777]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; axon extension [GO:0048675]; collateral sprouting [GO:0048668]; late nucleophagy [GO:0044805]; negative regulation of collateral sprouting [GO:0048671]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; protein autophosphorylation [GO:0046777]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18936157}; Peripheral membrane protein {ECO:0000269|PubMed:18936157}. Note=Localizes to pre-autophagosomal membrane.
Q8IYU2	reviewed	HACE1_HUMAN	E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1)	HACE1 KIAA1320	Homo sapiens (Human)	909	FUNCTION: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. {ECO:0000269|PubMed:15254018, ECO:0000269|PubMed:21988917, ECO:0000269|PubMed:22036506}.		cell cycle [GO:0007049]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; Rac protein signal transduction [GO:0016601]; regulation of cell migration [GO:0030334]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nuclear body [GO:0016604]; nucleus [GO:0005634]	small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nuclear body [GO:0016604]; nucleus [GO:0005634]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cell cycle [GO:0007049]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; Rac protein signal transduction [GO:0016601]; regulation of cell migration [GO:0030334]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
Q8IYU8	reviewed	MICU2_HUMAN	Calcium uptake protein 2, mitochondrial (EF-hand domain-containing family member A1)	MICU2 EFHA1	Homo sapiens (Human)	434	FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927). {ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26387864, ECO:0000269|PubMed:26903221}.		calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]	calcium channel complex [GO:0034704]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246]	calcium ion binding [GO:0005509]; protein heterodimerization activity [GO:0046982]	calcium channel complex [GO:0034704]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246]; calcium ion binding [GO:0005509]; protein heterodimerization activity [GO:0046982]; calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26774479, ECO:0000269|PubMed:27099988}.
Q8IYV9	reviewed	IZUM1_HUMAN	Izumo sperm-egg fusion protein 1 (Oocyte binding/fusion factor) (OBF) (Sperm-specific protein izumo)	IZUMO1	Homo sapiens (Human)	350	FUNCTION: Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Acts a ligand for the human-specific oolemma epitope FCRL3/MAIA during fertilization (PubMed:36070373). FCRL3/MAIA replaces IZUMO1R/JUNO as IZUMO1 receptor after sperm-egg adhesion, which permits species-specific gamete fusion (PubMed:36070373). {ECO:0000250|UniProtKB:Q9D9J7, ECO:0000269|PubMed:36070373}.	MISCELLANEOUS: Izumo is the name of a Japanese shrine to marriage. {ECO:0000305|PubMed:15759005}.	cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; heterotypic cell-cell adhesion [GO:0034113]; single fertilization [GO:0007338]; sperm-egg recognition [GO:0035036]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein complex involved in cell-cell adhesion [GO:0098635]	identical protein binding [GO:0042802]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein complex involved in cell-cell adhesion [GO:0098635]; identical protein binding [GO:0042802]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; heterotypic cell-cell adhesion [GO:0034113]; single fertilization [GO:0007338]; sperm-egg recognition [GO:0035036]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15759005}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:36070373}; Single-pass type I membrane protein {ECO:0000255}. Note=Localizes initially to the acrosome membrane of the sperm head (both outer and inner acrosomal membranes) (PubMed:36070373). During the acrosome reaction, translocates to the plasma membrane (PubMed:15759005, PubMed:36070373). {ECO:0000269|PubMed:15759005, ECO:0000269|PubMed:36070373}.
Q8IYW5	reviewed	RN168_HUMAN	E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168)	RNF168	Homo sapiens (Human)	571	FUNCTION: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). {ECO:0000255|HAMAP-Rule:MF_03066, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:20550933, ECO:0000269|PubMed:22373579, ECO:0000269|PubMed:22705371, ECO:0000269|PubMed:22713238, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:22980979, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538}.		DNA damage response [GO:0006974]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; epigenetic regulation of gene expression [GO:0040029]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of DNA repair [GO:0045739]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H2AK15 ubiquitin ligase activity [GO:0140858]; histone ubiquitin ligase activity [GO:0140852]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H2AK15 ubiquitin ligase activity [GO:0140858]; histone ubiquitin ligase activity [GO:0140852]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]; DNA damage response [GO:0006974]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; epigenetic regulation of gene expression [GO:0040029]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of DNA repair [GO:0045739]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03066, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:19500350, ECO:0000269|PubMed:21041483, ECO:0000269|PubMed:22742833}. Note=Localizes to double-strand breaks (DSBs) sites of DNA damage. {ECO:0000255|HAMAP-Rule:MF_03066}.
Q8IYX1	reviewed	TBC21_HUMAN	TBC1 domain family member 21 (Male germ cell Rab GTPase-activating protein)	TBC1D21 MGCRABGAP	Homo sapiens (Human)	336	FUNCTION: Acts as a GTPase-activating protein for Rab family protein(s) (PubMed:28067790, PubMed:19077034). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function (By similarity). Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail (By similarity). Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3 (By similarity). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978). {ECO:0000250|UniProtKB:Q9D9D3, ECO:0000269|PubMed:28067790, ECO:0000305|PubMed:19077034, ECO:0000305|PubMed:21128978}.		flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288]; sperm mitochondrial sheath assembly [GO:0120317]; spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; sperm midpiece [GO:0097225]	actin binding [GO:0003779]; GTPase activator activity [GO:0005096]	acrosomal vesicle [GO:0001669]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; sperm midpiece [GO:0097225]; actin binding [GO:0003779]; GTPase activator activity [GO:0005096]; flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288]; sperm mitochondrial sheath assembly [GO:0120317]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9D9D3}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9D9D3}. Note=Located at the edge of the acrosomal region, neck and annulus during spermiogenesis. Colocalizes with RAB3A at the acrosome-acroplaxome and neck regions of spermatids. Colocalizes with ACTB at the neck region in elongated spermatids. {ECO:0000250|UniProtKB:Q9D9D3}.
Q8IYX3	reviewed	CC116_HUMAN	Coiled-coil domain-containing protein 116	CCDC116	Homo sapiens (Human)	613				centrosome [GO:0005813]; cytoplasm [GO:0005737]		centrosome [GO:0005813]; cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25074808}.
Q8IYX7	reviewed	SAXO1_HUMAN	Stabilizer of axonemal microtubules 1	SAXO1 C9orf138 FAM154A	Homo sapiens (Human)	474	FUNCTION: May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature. {ECO:0000269|PubMed:25673876}.		cell projection organization [GO:0030030]; cellular response to cold [GO:0070417]; cold acclimation [GO:0009631]; positive regulation of cilium assembly [GO:0045724]; protein stabilization [GO:0050821]	axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]	microtubule binding [GO:0008017]	axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]; microtubule binding [GO:0008017]; cell projection organization [GO:0030030]; cellular response to cold [GO:0070417]; cold acclimation [GO:0009631]; positive regulation of cilium assembly [GO:0045724]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:25673876}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:25673876}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:25673876}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25673876}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:25673876}. Note=In multi-ciliated cells, localizes to the basal bodies and in non-ciliated cells, to the centrosome. In spermatozoa, colocalizes with microtubules along the length of the axoneme from its proximal end to its distal tip and with tubulin at the distal end of the flagellum and at the proximal centriole. {ECO:0000269|PubMed:25673876}.
Q8IYX8	reviewed	CE57L_HUMAN	Centrosomal protein CEP57L1 (Centrosomal protein 57kDa-like protein 1) (Centrosomal protein of 57 kDa-related protein) (Cep57R) (Cep57-related protein)	CEP57L1 C6orf182 CEP57R	Homo sapiens (Human)	460	FUNCTION: Centrosomal protein which may be required for microtubule attachment to centrosomes. {ECO:0000250}.			centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]	gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}.
Q8IYY4	reviewed	DZI1L_HUMAN	Cilium assembly protein DZIP1L (DAZ-interacting zinc finger protein 1-like)	DZIP1L	Homo sapiens (Human)	767	FUNCTION: Involved in primary cilium formation (PubMed:19852954, PubMed:28530676). Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane (PubMed:28530676). {ECO:0000269|PubMed:19852954, ECO:0000269|PubMed:28530676}.		ciliary transition zone assembly [GO:1905349]; cilium assembly [GO:0060271]; floor plate development [GO:0033504]; neural tube patterning [GO:0021532]; protein localization to cilium [GO:0061512]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224]	axoneme [GO:0005930]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]	metal ion binding [GO:0046872]	axoneme [GO:0005930]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; ciliary transition zone assembly [GO:1905349]; cilium assembly [GO:0060271]; floor plate development [GO:0033504]; neural tube patterning [GO:0021532]; protein localization to cilium [GO:0061512]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19852954, ECO:0000269|PubMed:28530676}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28530676}. Note=Localizes to centrioles and to the distal ends of basal bodies (PubMed:28530676). {ECO:0000269|PubMed:28530676}.
Q8IZ07	reviewed	AN13A_HUMAN	Ankyrin repeat domain-containing protein 13A (Protein KE03)	ANKRD13A ANKRD13	Homo sapiens (Human)	590	FUNCTION: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269|PubMed:22298428}.		negative regulation of protein localization to endosome [GO:1905667]; negative regulation of receptor internalization [GO:0002091]	cytoplasm [GO:0005737]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	ubiquitin-dependent protein binding [GO:0140036]	cytoplasm [GO:0005737]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ubiquitin-dependent protein binding [GO:0140036]; negative regulation of protein localization to endosome [GO:1905667]; negative regulation of receptor internalization [GO:0002091]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22298428}. Late endosome {ECO:0000269|PubMed:22298428}. Note=Interaction with EGFR may enhance association with the cell membrane.
Q8IZ20	reviewed	ZN683_HUMAN	Tissue-resident T-cell transcription regulator protein ZNF683 (Homolog of Blimp-1 in T-cell) (Hobit) (Zinc finger protein 683)	ZNF683	Homo sapiens (Human)	524	FUNCTION: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Also plays a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions. {ECO:0000250|UniProtKB:I7HJS4}.; FUNCTION: [Isoform 1]: Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T-cells. {ECO:0000269|PubMed:26179882}.; FUNCTION: [Isoform 2]: Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T cells. {ECO:0000269|PubMed:26179882}.		adaptive immune response [GO:0002250]; cellular response to ionomycin [GO:1904637]; innate immune response [GO:0045087]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; positive regulation of gene expression [GO:0010628]; regulation of extrathymic T cell differentiation [GO:0033082]; regulation of gene expression [GO:0010468]; regulation of natural killer cell differentiation [GO:0032823]; regulation of natural killer cell differentiation involved in immune response [GO:0032826]; regulation of NK T cell differentiation [GO:0051136]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell receptor signaling pathway [GO:0050852]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; adaptive immune response [GO:0002250]; cellular response to ionomycin [GO:1904637]; innate immune response [GO:0045087]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; positive regulation of gene expression [GO:0010628]; regulation of extrathymic T cell differentiation [GO:0033082]; regulation of gene expression [GO:0010468]; regulation of natural killer cell differentiation [GO:0032823]; regulation of natural killer cell differentiation involved in immune response [GO:0032826]; regulation of NK T cell differentiation [GO:0051136]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IZ21	reviewed	PHAR4_HUMAN	Phosphatase and actin regulator 4	PHACTR4 PRO2963	Homo sapiens (Human)	702	FUNCTION: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; closure of optic fissure [GO:0061386]; enteric nervous system development [GO:0048484]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; neural crest cell migration [GO:0001755]; neural tube closure [GO:0001843]; positive regulation of catalytic activity [GO:0043085]; regulation of cell cycle [GO:0051726]; Rho protein signal transduction [GO:0007266]	cytoplasm [GO:0005737]; lamellipodium [GO:0030027]	actin binding [GO:0003779]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase activator activity [GO:0072542]	cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; actin binding [GO:0003779]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase activator activity [GO:0072542]; actin cytoskeleton organization [GO:0030036]; closure of optic fissure [GO:0061386]; enteric nervous system development [GO:0048484]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; neural crest cell migration [GO:0001755]; neural tube closure [GO:0001843]; positive regulation of catalytic activity [GO:0043085]; regulation of cell cycle [GO:0051726]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}.
Q8IZ41	reviewed	RASEF_HUMAN	Ras and EF-hand domain-containing protein (Ras-related protein Rab-45)	RASEF RAB45	Homo sapiens (Human)	740	FUNCTION: Binds predominantly GDP, and also GTP (PubMed:17448446). Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules (PubMed:30814157). {ECO:0000269|PubMed:17448446, ECO:0000269|PubMed:30814157}.		vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]	calcium ion binding [GO:0005509]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17448446}.
Q8IZ52	reviewed	CHSS2_HUMAN	Chondroitin sulfate synthase 2 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 2) (Chondroitin-polymerizing factor) (ChPF) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II) (N-acetylgalactosaminyltransferase 2)	CHPF CSS2 UNQ651/PRO1281	Homo sapiens (Human)	775	FUNCTION: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Seems to act as a specific activating factor for CHSY1 in chondroitin polymerization (PubMed:12716890). {ECO:0000269|PubMed:12716890, ECO:0000269|PubMed:12761225}.; FUNCTION: [Isoform 2]: May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, may enhance cell viability and protect cells from oxidative stress. {ECO:0000269|PubMed:22082830}.		chondroitin sulfate biosynthetic process [GO:0030206]	cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; mitochondrial matrix [GO:0005759]	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510]	cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; mitochondrial matrix [GO:0005759]; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510]; chondroitin sulfate biosynthetic process [GO:0030206]	SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:22082830}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol {ECO:0000269|PubMed:22082830}. Mitochondrion {ECO:0000269|PubMed:22082830}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion matrix {ECO:0000269|PubMed:22082830}.
Q8IZ69	reviewed	TRM2A_HUMAN	tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.35) (mRNA (uracil-5-)-methyltransferase TRMT2A) (EC 2.1.1.-)	TRMT2A	Homo sapiens (Human)	625	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs (PubMed:31361898, PubMed:33799331). Also able to mediate the formation of 5-methyl-uridine in some mRNAs (PubMed:34123281). {ECO:0000269|PubMed:31361898, ECO:0000269|PubMed:33799331, ECO:0000269|PubMed:34123281, ECO:0000269|PubMed:34556860}.		mRNA processing [GO:0006397]	cytosol [GO:0005829]	C-methyltransferase activity [GO:0008169]; RNA binding [GO:0003723]; S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity [GO:0030697]	cytosol [GO:0005829]; C-methyltransferase activity [GO:0008169]; RNA binding [GO:0003723]; S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity [GO:0030697]; mRNA processing [GO:0006397]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:31361898}.
Q8IZ96	reviewed	CKLF1_HUMAN	CKLF-like MARVEL transmembrane domain-containing protein 1 (Chemokine-like factor superfamily member 1)	CMTM1 CKLFSF1	Homo sapiens (Human)	169			chemotaxis [GO:0006935]	extracellular space [GO:0005615]; membrane [GO:0016020]	cytokine activity [GO:0005125]	extracellular space [GO:0005615]; membrane [GO:0016020]; cytokine activity [GO:0005125]; chemotaxis [GO:0006935]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q8IZA0	reviewed	K319L_HUMAN	Dyslexia-associated protein KIAA0319-like protein (Adeno-associated virus receptor) (AAVR)	KIAA0319L AAVR KIAA1837 PP791	Homo sapiens (Human)	1049	FUNCTION: Possible role in axon guidance through interaction with RTN4R. {ECO:0000269|PubMed:20697954}.; FUNCTION: (Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system. {ECO:0000269|PubMed:26814968}.		neuron migration [GO:0001764]	cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]		cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; neuron migration [GO:0001764]	SUBCELLULAR LOCATION: Cytoplasmic granule membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:26814968}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:26814968}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:26814968}; Multi-pass membrane protein {ECO:0000305}. Note=Traffics from the plasma membrane to the trans-Golgi network. {ECO:0000269|PubMed:26814968}.
Q8IZC4	reviewed	RTKN2_HUMAN	Rhotekin-2 (Pleckstrin homology domain-containing family K member 1) (PH domain-containing family K member 1)	RTKN2 PLEKHK1	Homo sapiens (Human)	609	FUNCTION: May play an important role in lymphopoiesis. {ECO:0000269|PubMed:15504364}.		hemopoiesis [GO:0030097]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; hemopoiesis [GO:0030097]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; signal transduction [GO:0007165]	
Q8IZC6	reviewed	CORA1_HUMAN	Collagen alpha-1(XXVII) chain	COL27A1 KIAA1870	Homo sapiens (Human)	1860	FUNCTION: Plays a role during the calcification of cartilage and the transition of cartilage to bone. {ECO:0000269|PubMed:17693149}.		angiogenesis [GO:0001525]; collagen fibril organization [GO:0030199]; endothelial cell morphogenesis [GO:0001886]; growth plate cartilage chondrocyte development [GO:0003431]; notochord development [GO:0030903]; skeletal system development [GO:0001501]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrillar collagen trimer [GO:0005583]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrillar collagen trimer [GO:0005583]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]; angiogenesis [GO:0001525]; collagen fibril organization [GO:0030199]; endothelial cell morphogenesis [GO:0001886]; growth plate cartilage chondrocyte development [GO:0003431]; notochord development [GO:0030903]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Note=Found on some small banded collagen fibrils and meshworks. {ECO:0000250}.
Q8IZC7	reviewed	ZN101_HUMAN	Zinc finger protein 101 (Zinc finger protein HZF12)	ZNF101	Homo sapiens (Human)	436	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IZD2	reviewed	KMT2E_HUMAN	Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5)	KMT2E MLL5	Homo sapiens (Human)	1858	FUNCTION: Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:24130829, PubMed:23798402). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:24130829, PubMed:23798402). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}.		cell cycle [GO:0007049]; chromatin organization [GO:0006325]; DNA methylation [GO:0006306]; erythrocyte differentiation [GO:0030218]; neutrophil activation [GO:0042119]; neutrophil mediated immunity [GO:0002446]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; regulation of DNA-templated transcription [GO:0006355]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; microtubule organizing center [GO:0005815]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Rpd3L-Expanded complex [GO:0070210]; Set3 complex [GO:0034967]	enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; microtubule organizing center [GO:0005815]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Rpd3L-Expanded complex [GO:0070210]; Set3 complex [GO:0034967]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; transcription coactivator activity [GO:0003713]; cell cycle [GO:0007049]; chromatin organization [GO:0006325]; DNA methylation [GO:0006306]; erythrocyte differentiation [GO:0030218]; neutrophil activation [GO:0042119]; neutrophil mediated immunity [GO:0002446]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:23798402}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23798402}. Nucleus speckle {ECO:0000269|PubMed:14718661}. Note=Absent from the nucleolus (PubMed:14718661). Localizes to chromosome during interphase and to centrosomes during mitosis (PubMed:23798402). Dissociation from mitotic chromosome is likely due to histone H3 phosphorylation on 'Thr-3' and 'Thr-6' (PubMed:23798402). {ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:23798402}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleoplasm {ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26678539}. Nucleus speckle {ECO:0000269|PubMed:23798402}. Note=Absent from the nucleolus (PubMed:23629655). Localizes to chromosome during interphase and to nucleus speckle during mitosis (PubMed:23798402). Dissociation from mitotic chromosome is likely due to histone H3 phosphorylation on 'Thr-3' and 'Thr-6' (PubMed:23798402). {ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402}.; SUBCELLULAR LOCATION: [Isoform NKp44L]: Cytoplasm {ECO:0000269|PubMed:23958951}. Cell membrane {ECO:0000269|PubMed:23958951}; Peripheral membrane protein {ECO:0000269|PubMed:23958951}.
Q8IZD4	reviewed	DCP1B_HUMAN	mRNA-decapping enzyme 1B (EC 3.6.1.62)	DCP1B	Homo sapiens (Human)	617	FUNCTION: May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}.		deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; enzyme activator activity [GO:0008047]; mRNA binding [GO:0003729]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; enzyme activator activity [GO:0008047]; mRNA binding [GO:0003729]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15067023}. Nucleus {ECO:0000250|UniProtKB:Q9NPI6}.
Q8IZD6	reviewed	S22AF_HUMAN	Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1)	SLC22A15 FLIPT1 UNQ9429/PRO34686	Homo sapiens (Human)	547	FUNCTION: Organic zwitterion/cation transporter with apparent specificity for amino acids and their derivatives. Has low affinity for its substrates and may regulate their flux across the plasma membrane at high substrate concentrations (PubMed:33124720). Bidirectionally transports carnitine and acetylcarnitine, possibly regulating their cytosolic abundance and further fatty acid catabolism via beta oxidation (PubMed:33124720). Displays high transport activity toward zwitterionic substrates such as glycine betaine and diet-derived ergothioneine and carnosine. Can transport cations having an indole skeleton such as thiamine with lower efficiency. Does not transports agmatine (PubMed:33124720, PubMed:15028572). The transport mechanism, symport with sodium or facilitated diffusion allosterically regulated by sodium, remains to be elucidated (Probable). {ECO:0000269|PubMed:15028572, ECO:0000269|PubMed:33124720, ECO:0000305|PubMed:33124720}.		monoatomic ion transport [GO:0006811]	plasma membrane [GO:0005886]	amino-acid betaine transmembrane transporter activity [GO:0015199]	plasma membrane [GO:0005886]; amino-acid betaine transmembrane transporter activity [GO:0015199]; monoatomic ion transport [GO:0006811]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33124720}; Multi-pass membrane protein {ECO:0000255}.
Q8IZD9	reviewed	DOCK3_HUMAN	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP)	DOCK3 KIAA0299 MOCA	Homo sapiens (Human)	2030	FUNCTION: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity). {ECO:0000250}.		neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]; neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8IZE3	reviewed	PACE1_HUMAN	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3)	SCYL3 PACE1	Homo sapiens (Human)	742	FUNCTION: May play a role in regulating cell adhesion/migration complexes in migrating cells. {ECO:0000269|PubMed:12651155}.		cell migration [GO:0016477]; inflammatory response [GO:0006954]; neuron development [GO:0048666]; protein localization [GO:0008104]; spinal cord motor neuron differentiation [GO:0021522]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; cell migration [GO:0016477]; inflammatory response [GO:0006954]; neuron development [GO:0048666]; protein localization [GO:0008104]; spinal cord motor neuron differentiation [GO:0021522]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12651155}. Golgi apparatus {ECO:0000269|PubMed:12651155}. Cell projection, lamellipodium {ECO:0000269|PubMed:12651155}. Note=Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.
Q8IZF0	reviewed	NALCN_HUMAN	Sodium leak channel NALCN (CanIon) (Sodium leak channel non-selective protein) (Voltage gated channel-like protein 1)	NALCN VGCNL1	Homo sapiens (Human)	1738	FUNCTION: Voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (PubMed:17448995, PubMed:31409833). NALCN channel functions as a multi-protein complex, which consists at least of NALCN, NALF1, UNC79 and UNC80 (PubMed:32494638, PubMed:33203861). NALCN is the voltage-sensing, pore-forming subunit of the NALCN channel complex (PubMed:17448995). NALCN channel complex is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (PubMed:32494638). In addition to its role in regulating neuronal excitability, is required for normal respiratory rhythm, systemic osmoregulation by controlling the serum sodium concentration and in the regulation of the intestinal pace-making activity in the interstitial cells of Cajal (By similarity). NALCN channel is also activated by neuropeptides such as neurotensin and substance P (SP) through a SRC family kinases-dependent pathway (By similarity). In addition, NALCN activity is enhanced/modulated by several GPCRs, such as CHRM3 (By similarity). {ECO:0000250|UniProtKB:Q8BXR5, ECO:0000269|PubMed:17448995, ECO:0000269|PubMed:31409833, ECO:0000269|PubMed:32494638, ECO:0000269|PubMed:33203861}.		calcium ion transmembrane transport [GO:0070588]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of resting membrane potential [GO:0060075]; sodium ion transmembrane transport [GO:0035725]	plasma membrane [GO:0005886]	leak channel activity [GO:0022840]; monoatomic cation channel activity [GO:0005261]; sodium channel activity [GO:0005272]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated sodium channel activity [GO:0005248]	plasma membrane [GO:0005886]; leak channel activity [GO:0022840]; monoatomic cation channel activity [GO:0005261]; sodium channel activity [GO:0005272]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated sodium channel activity [GO:0005248]; calcium ion transmembrane transport [GO:0070588]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of resting membrane potential [GO:0060075]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31409833, ECO:0000269|PubMed:32494638, ECO:0000269|PubMed:32698188}; Multi-pass membrane protein {ECO:0000255}.
Q8IZF2	reviewed	AGRF5_HUMAN	Adhesion G protein-coupled receptor F5 (G-protein coupled receptor 116)	ADGRF5 GPR116 KIAA0758	Homo sapiens (Human)	1346	FUNCTION: Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function. {ECO:0000250|UniProtKB:G5E8Q8}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; energy reserve metabolic process [GO:0006112]; erythrocyte development [GO:0048821]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; glomerular filtration [GO:0003094]; glucose homeostasis [GO:0042593]; macrophage activation [GO:0042116]; negative regulation of macrophage activation [GO:0043031]; pharyngeal arch artery morphogenesis [GO:0061626]; phospholipid biosynthetic process [GO:0008654]; positive regulation of phospholipid biosynthetic process [GO:0071073]; regulation of lipid metabolic process [GO:0019216]; surfactant homeostasis [GO:0043129]	apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; energy reserve metabolic process [GO:0006112]; erythrocyte development [GO:0048821]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; glomerular filtration [GO:0003094]; glucose homeostasis [GO:0042593]; macrophage activation [GO:0042116]; negative regulation of macrophage activation [GO:0043031]; pharyngeal arch artery morphogenesis [GO:0061626]; phospholipid biosynthetic process [GO:0008654]; positive regulation of phospholipid biosynthetic process [GO:0071073]; regulation of lipid metabolic process [GO:0019216]; surfactant homeostasis [GO:0043129]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9WVT0}; Multi-pass membrane protein {ECO:0000255}.
Q8IZF3	reviewed	AGRF4_HUMAN	Adhesion G protein-coupled receptor F4 (G-protein coupled receptor 115) (G-protein coupled receptor PGR18)	ADGRF4 GPR115 PGR18	Homo sapiens (Human)	695	FUNCTION: Orphan receptor.	MISCELLANEOUS: Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain. {ECO:0000250|UniProtKB:Q9D2L6}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q8IZF6	reviewed	AGRG4_HUMAN	Adhesion G-protein coupled receptor G4 (G-protein coupled receptor 112)	ADGRG4 GPR112	Homo sapiens (Human)	3080	FUNCTION: Orphan receptor.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q8IZF7	reviewed	AGRF2_HUMAN	Putative adhesion G protein-coupled receptor F2P (Adhesion G-protein coupled receptor F2) (G-protein coupled receptor 111) (G-protein coupled receptor PGR20)	ADGRF2P ADGRF2 GPR111 PGR20	Homo sapiens (Human)	708	FUNCTION: Orphan receptor.	MISCELLANEOUS: Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain. {ECO:0000250|UniProtKB:E9Q4J9}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q8IZH2	reviewed	XRN1_HUMAN	5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)	XRN1 SEP1	Homo sapiens (Human)	1706	FUNCTION: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}.	MISCELLANEOUS: Down-regulated in OGS biopsy.	cellular response to cycloheximide [GO:0071409]; cellular response to puromycin [GO:1905795]; histone mRNA catabolic process [GO:0071044]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation [GO:0017148]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; response to testosterone [GO:0033574]; rRNA catabolic process [GO:0016075]	cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]	5'-3' RNA exonuclease activity [GO:0004534]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; 5'-3' RNA exonuclease activity [GO:0004534]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; cellular response to cycloheximide [GO:0071409]; cellular response to puromycin [GO:1905795]; histone mRNA catabolic process [GO:0071044]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation [GO:0017148]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; response to testosterone [GO:0033574]; rRNA catabolic process [GO:0016075]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12515382, ECO:0000269|PubMed:14580940, ECO:0000269|PubMed:9802570}. Note=Discrete foci at the inner surface of the cell membrane.
Q8IZI9	reviewed	IFNL3_HUMAN	Interferon lambda-3 (IFN-lambda-3) (Cytokine Zcyto22) (Interleukin-28B) (IL-28B) (Interleukin-28C) (IL-28C)	IFNL3 IL28B IL28C ZCYTO22	Homo sapiens (Human)	196	FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210}.		cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of immune response [GO:0050778]; receptor signaling pathway via JAK-STAT [GO:0007259]; type III interferon-mediated signaling pathway [GO:0038196]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of immune response [GO:0050778]; receptor signaling pathway via JAK-STAT [GO:0007259]; type III interferon-mediated signaling pathway [GO:0038196]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12483210}.
Q8IZJ1	reviewed	UNC5B_HUMAN	Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1)	UNC5B P53RDL1 UNC5H2 UNQ1883/PRO4326	Homo sapiens (Human)	945	FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity). {ECO:0000250|UniProtKB:O08722, ECO:0000250|UniProtKB:Q8K1S3, ECO:0000269|PubMed:12598906}.	MISCELLANEOUS: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.	angiogenesis [GO:0001525]; anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]	membrane raft [GO:0045121]; plasma membrane [GO:0005886]	netrin receptor activity [GO:0005042]	membrane raft [GO:0045121]; plasma membrane [GO:0005886]; netrin receptor activity [GO:0005042]; angiogenesis [GO:0001525]; anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25374360}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O08722}. Membrane raft {ECO:0000250|UniProtKB:O08722}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:O08722}.
Q8IZJ3	reviewed	CPMD8_HUMAN	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8	CPAMD8 KIAA1283	Homo sapiens (Human)	1885			eye development [GO:0001654]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; serine-type endopeptidase inhibitor activity [GO:0004867]; eye development [GO:0001654]	SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:15177561}. Cell membrane {ECO:0000269|PubMed:15177561}; Peripheral membrane protein {ECO:0000269|PubMed:15177561}; Extracellular side {ECO:0000269|PubMed:15177561}.
Q8IZK6	reviewed	MCLN2_HUMAN	Mucolipin-2 (Transient receptor potential channel mucolipin 2) (TRPML2)	MCOLN2	Homo sapiens (Human)	566	FUNCTION: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). {ECO:0000250|UniProtKB:Q8K595, ECO:0000269|PubMed:17662026, ECO:0000269|PubMed:19885840, ECO:0000269|PubMed:19940139, ECO:0000305}.		adaptive immune response [GO:0002250]; calcium ion transmembrane transport [GO:0070588]; innate immune response [GO:0045087]; macrophage migration [GO:1905517]; neutrophil migration [GO:1990266]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of macrophage inflammatory protein 1 alpha production [GO:0071642]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; protein transport [GO:0015031]	late endosome membrane [GO:0031902]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; NAADP-sensitive calcium-release channel activity [GO:0072345]	late endosome membrane [GO:0031902]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; NAADP-sensitive calcium-release channel activity [GO:0072345]; adaptive immune response [GO:0002250]; calcium ion transmembrane transport [GO:0070588]; innate immune response [GO:0045087]; macrophage migration [GO:1905517]; neutrophil migration [GO:1990266]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of macrophage inflammatory protein 1 alpha production [GO:0071642]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17662026}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F6RG56}. Late endosome membrane {ECO:0000269|PubMed:17662026}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F6RG56}. Lysosome membrane {ECO:0000269|PubMed:17662026}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F6RG56}. Recycling endosome membrane {ECO:0000269|PubMed:17662026}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F6RG56}. Note=Localizes to recycling endosomes in activated macrophages and microglia. {ECO:0000250|UniProtKB:Q8K595}.
Q8IZL2	reviewed	MAML2_HUMAN	Mastermind-like protein 2 (Mam-2)	MAML2 KIAA1819	Homo sapiens (Human)	1156	FUNCTION: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}.		Notch signaling pathway [GO:0007219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; Notch signaling pathway [GO:0007219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:12370315}. Note=Nuclear, in a punctate manner.
Q8IZL8	reviewed	PELP1_HUMAN	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)	PELP1 HMX3 MNAR	Homo sapiens (Human)	1130	FUNCTION: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}.	MISCELLANEOUS: Expression is increased in breast tumor samples. {ECO:0000269|PubMed:11481323}.	cellular response to estrogen stimulus [GO:0071391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; rRNA processing [GO:0006364]	cytoplasm [GO:0005737]; euchromatin [GO:0000791]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; RNA binding [GO:0003723]; SUMO binding [GO:0032183]	cytoplasm [GO:0005737]; euchromatin [GO:0000791]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; RNA binding [GO:0003723]; SUMO binding [GO:0032183]; cellular response to estrogen stimulus [GO:0071391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21326211}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21326211}. Nucleus {ECO:0000269|PubMed:11481323}. Cytoplasm {ECO:0000269|PubMed:11481323}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors (PubMed:16140940). {ECO:0000250|UniProtKB:Q9DBD5, ECO:0000269|PubMed:16140940}.
Q8IZL9	reviewed	CDK20_HUMAN	Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42)	CDK20 CCRK CDCH	Homo sapiens (Human)	346	FUNCTION: Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. {ECO:0000250, ECO:0000269|PubMed:14597612}.		cell cycle [GO:0007049]; cell division [GO:0051301]; embryonic brain development [GO:1990403]; embryonic camera-type eye development [GO:0031076]; embryonic skeletal system development [GO:0048706]; floor plate formation [GO:0021508]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; neural tube closure [GO:0001843]; phosphorylation [GO:0016310]; protein localization to cilium [GO:0061512]; regulation of protein maturation [GO:1903317]; roof of mouth development [GO:0060021]	cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell cycle [GO:0007049]; cell division [GO:0051301]; embryonic brain development [GO:1990403]; embryonic camera-type eye development [GO:0031076]; embryonic skeletal system development [GO:0048706]; floor plate formation [GO:0021508]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; neural tube closure [GO:0001843]; phosphorylation [GO:0016310]; protein localization to cilium [GO:0061512]; regulation of protein maturation [GO:1903317]; roof of mouth development [GO:0060021]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14597612}. Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
Q8IZN3	reviewed	ZDH14_HUMAN	Palmitoyltransferase ZDHHC14 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 14) (DHHC-14) (NEW1 domain-containing protein) (NEW1CP) (Zinc finger DHHC domain-containing protein 14)	ZDHHC14	Homo sapiens (Human)	488	FUNCTION: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and thereby regulate G protein-coupled receptor signaling (PubMed:27481942). May play a role in cell differentiation and apoptosis (PubMed:21151021, PubMed:24407904). {ECO:0000269|PubMed:21151021, ECO:0000269|PubMed:24407904, ECO:0000269|PubMed:27481942}.		peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16647879}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:27481942}; Multi-pass membrane protein {ECO:0000255}.
Q8IZP0	reviewed	ABI1_HUMAN	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)	ABI1 SSH3BP1	Homo sapiens (Human)	508	FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.		actin polymerization or depolymerization [GO:0008154]; dendrite morphogenesis [GO:0048813]; lamellipodium morphogenesis [GO:0072673]; megakaryocyte development [GO:0035855]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein tyrosine kinase activity [GO:0061098]; somitogenesis [GO:0001756]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; SCAR complex [GO:0031209]	cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; protein tyrosine kinase activator activity [GO:0030296]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; SCAR complex [GO:0031209]; cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; protein tyrosine kinase activator activity [GO:0030296]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; actin polymerization or depolymerization [GO:0008154]; dendrite morphogenesis [GO:0048813]; lamellipodium morphogenesis [GO:0072673]; megakaryocyte development [GO:0035855]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein tyrosine kinase activity [GO:0061098]; somitogenesis [GO:0001756]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Postsynaptic density {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity). {ECO:0000250}.
Q8IZP1	reviewed	TBC3A_HUMAN	TBC1 domain family member 3 (Prostate cancer gene 17 protein) (Protein TRE17-alpha) (Rab GTPase-activating protein PRC17)	TBC1D3 PRC17 TBC1D3A	Homo sapiens (Human)	549	FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. {ECO:0000269|PubMed:12359748}.	MISCELLANEOUS: TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor.		early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23578663}; Lipid-anchor {ECO:0000269|PubMed:23578663}. Note=Associated with lipid rafts.
Q8IZP9	reviewed	AGRG2_HUMAN	Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Human epididymis-specific protein 6) (He6)	ADGRG2 GPR64 HE6 TM7LN2	Homo sapiens (Human)	1017	FUNCTION: Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis. {ECO:0000250|UniProtKB:Q8CJ12}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; spermatogenesis [GO:0007283]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12420295}; Multi-pass membrane protein {ECO:0000255}.
Q8IZQ1	reviewed	WDFY3_HUMAN	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy)	WDFY3 KIAA0993	Homo sapiens (Human)	3526	FUNCTION: Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27008544}.		aggrephagy [GO:0035973]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; PML body [GO:0016605]	1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; PML body [GO:0016605]; 1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872]; aggrephagy [GO:0035973]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:20971078}. Cytoplasm, cytosol {ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:20971078}. Nucleus, PML body {ECO:0000269|PubMed:20168092}. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:15292400}; Cytoplasmic side {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:Q6VNB8}. Cell projection, axon {ECO:0000250|UniProtKB:Q6VNB8}. Note=Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures (PubMed:15292400, PubMed:20168092, PubMed:20971078, PubMed:20417604). This redistribution is dependent on p62/SQSTM1 (PubMed:20168092). When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (PubMed:20168092). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (By similarity). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:20971078}.
Q8IZQ8	reviewed	MYCD_HUMAN	Myocardin	MYOCD MYCD	Homo sapiens (Human)	938	FUNCTION: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). {ECO:0000250, ECO:0000269|PubMed:12640126, ECO:0000269|PubMed:31513549}.		cardiac muscle cell apoptotic process [GO:0010659]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cardiac ventricle development [GO:0003231]; cardiocyte differentiation [GO:0035051]; cellular component maintenance [GO:0043954]; digestive tract development [GO:0048565]; ductus arteriosus closure [GO:0097070]; lung alveolus development [GO:0048286]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of skeletal muscle cell differentiation [GO:2001015]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of cell growth by extracellular stimulus [GO:0001560]; regulation of myoblast differentiation [GO:0045661]; regulation of phenotypic switching [GO:1900239]; regulation of smooth muscle cell differentiation [GO:0051150]; response to hypoxia [GO:0001666]; smooth muscle cell differentiation [GO:0051145]; transcription by RNA polymerase II [GO:0006366]; transcription initiation-coupled chromatin remodeling [GO:0045815]; urinary bladder development [GO:0060157]; uterus development [GO:0060065]; vasculogenesis [GO:0001570]; ventricular cardiac muscle cell differentiation [GO:0055012]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; R-SMAD binding [GO:0070412]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; R-SMAD binding [GO:0070412]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; cardiac muscle cell apoptotic process [GO:0010659]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cardiac ventricle development [GO:0003231]; cardiocyte differentiation [GO:0035051]; cellular component maintenance [GO:0043954]; digestive tract development [GO:0048565]; ductus arteriosus closure [GO:0097070]; lung alveolus development [GO:0048286]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of skeletal muscle cell differentiation [GO:2001015]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of cell growth by extracellular stimulus [GO:0001560]; regulation of myoblast differentiation [GO:0045661]; regulation of phenotypic switching [GO:1900239]; regulation of smooth muscle cell differentiation [GO:0051150]; response to hypoxia [GO:0001666]; smooth muscle cell differentiation [GO:0051145]; transcription by RNA polymerase II [GO:0006366]; transcription initiation-coupled chromatin remodeling [GO:0045815]; urinary bladder development [GO:0060157]; uterus development [GO:0060065]; vasculogenesis [GO:0001570]; ventricular cardiac muscle cell differentiation [GO:0055012]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8IZR5	reviewed	CKLF4_HUMAN	CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4)	CMTM4 CKLFSF4	Homo sapiens (Human)	234	FUNCTION: Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation. {ECO:0000269|PubMed:28813410}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q8IZT6	reviewed	ASPM_HUMAN	Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog)	ASPM MCPH5	Homo sapiens (Human)	3477	FUNCTION: Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}.		asymmetric cell division [GO:0008356]; cerebral cortex development [GO:0021987]; developmental growth [GO:0048589]; forebrain neuroblast division [GO:0021873]; maintenance of centrosome location [GO:0051661]; male gonad development [GO:0008584]; meiotic spindle assembly [GO:0090306]; negative regulation of asymmetric cell division [GO:0045769]; negative regulation of neuron differentiation [GO:0045665]; neuron migration [GO:0001764]; neuronal stem cell population maintenance [GO:0097150]; oogenesis [GO:0048477]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of meiotic cell cycle [GO:0051445]; spermatogenesis [GO:0007283]; spindle localization [GO:0051653]; spindle organization [GO:0007051]	apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; meiotic spindle [GO:0072687]; microtubule minus-end [GO:0036449]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]	calmodulin binding [GO:0005516]	apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; meiotic spindle [GO:0072687]; microtubule minus-end [GO:0036449]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]; calmodulin binding [GO:0005516]; asymmetric cell division [GO:0008356]; cerebral cortex development [GO:0021987]; developmental growth [GO:0048589]; forebrain neuroblast division [GO:0021873]; maintenance of centrosome location [GO:0051661]; male gonad development [GO:0008584]; meiotic spindle assembly [GO:0090306]; negative regulation of asymmetric cell division [GO:0045769]; negative regulation of neuron differentiation [GO:0045665]; neuron migration [GO:0001764]; neuronal stem cell population maintenance [GO:0097150]; oogenesis [GO:0048477]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of meiotic cell cycle [GO:0051445]; spermatogenesis [GO:0007283]; spindle localization [GO:0051653]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15972725}. Nucleus {ECO:0000250}. Note=The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin (By similarity). Localizes to spindle poles during mitosis (PubMed:19690332). Associates with microtubule minus ends (By similarity). {ECO:0000250|UniProtKB:Q8CJ27}.
Q8IZT8	reviewed	HS3S5_HUMAN	Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (3-OST-5) (Heparan sulfate 3-O-sulfotransferase 5) (h3-OST-5)	HS3ST5 3OST5 HS3OST5	Homo sapiens (Human)	346	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. {ECO:0000269|PubMed:12138164}.		heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; negative regulation of coagulation [GO:0050819]; protein sulfation [GO:0006477]; regulation of viral entry into host cell [GO:0046596]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; negative regulation of coagulation [GO:0050819]; protein sulfation [GO:0006477]; regulation of viral entry into host cell [GO:0046596]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8IZU0	reviewed	FAM9B_HUMAN	Protein FAM9B	FAM9B	Homo sapiens (Human)	186			meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286]	nucleoplasm [GO:0005654]; synaptonemal complex [GO:0000795]		nucleoplasm [GO:0005654]; synaptonemal complex [GO:0000795]; meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12213195}.
Q8IZU1	reviewed	FAM9A_HUMAN	Protein FAM9A	FAM9A	Homo sapiens (Human)	332			meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286]	nucleolus [GO:0005730]; synaptonemal complex [GO:0000795]		nucleolus [GO:0005730]; synaptonemal complex [GO:0000795]; meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12213195}.
Q8IZU3	reviewed	SYCP3_HUMAN	Synaptonemal complex protein 3 (SCP-3)	SYCP3 SCP3	Homo sapiens (Human)	236	FUNCTION: Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120). Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity). {ECO:0000250|UniProtKB:P70281, ECO:0000269|PubMed:14643120}.		cell division [GO:0051301]; male meiosis I [GO:0007141]; meiotic cell cycle [GO:0051321]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]	chromosome, centromeric region [GO:0000775]; lateral element [GO:0000800]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]	DNA binding [GO:0003677]	chromosome, centromeric region [GO:0000775]; lateral element [GO:0000800]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]; DNA binding [GO:0003677]; cell division [GO:0051301]; male meiosis I [GO:0007141]; meiotic cell cycle [GO:0051321]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q60547}. Chromosome {ECO:0000250|UniProtKB:Q60547}. Chromosome, centromere {ECO:0000250|UniProtKB:Q60547}. Note=It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres. {ECO:0000250|UniProtKB:Q60547}.
Q8IZU9	reviewed	KIRR3_HUMAN	Kin of IRRE-like protein 3 (Kin of irregular chiasm-like protein 3) (Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3]	KIRREL3 KIAA1867 NEPH2 UNQ5923/PRO4502/PRO19814	Homo sapiens (Human)	778	FUNCTION: Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells. {ECO:0000250|UniProtKB:Q8BR86}.		cell-cell adhesion [GO:0098609]; glomerulus morphogenesis [GO:0072102]; hemopoiesis [GO:0030097]; hippocampus development [GO:0021766]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inter-male aggressive behavior [GO:0002121]; neuron migration [GO:0001764]; neuron projection morphogenesis [GO:0048812]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; synapse assembly [GO:0007416]	axon [GO:0030424]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	cell adhesion molecule binding [GO:0050839]	axon [GO:0030424]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; cell adhesion molecule binding [GO:0050839]; cell-cell adhesion [GO:0098609]; glomerulus morphogenesis [GO:0072102]; hemopoiesis [GO:0030097]; hippocampus development [GO:0021766]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inter-male aggressive behavior [GO:0002121]; neuron migration [GO:0001764]; neuron projection morphogenesis [GO:0048812]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19012874}; Single-pass type I membrane protein {ECO:0000269|PubMed:19012874}.; SUBCELLULAR LOCATION: [Processed kin of IRRE-like protein 3]: Secreted {ECO:0000250|UniProtKB:Q8BR86}.
Q8IZV5	reviewed	RDH10_HUMAN	Retinol dehydrogenase 10 (EC 1.1.1.300) (Short chain dehydrogenase/reductase family 16C member 4)	RDH10 SDR16C4 UNQ9375/PRO34191	Homo sapiens (Human)	341	FUNCTION: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol. {ECO:0000269|PubMed:12407145}.		bud elongation involved in lung branching [GO:0060449]; ear development [GO:0043583]; embryonic camera-type eye development [GO:0031076]; embryonic forelimb morphogenesis [GO:0035115]; embryonic viscerocranium morphogenesis [GO:0048703]; gonad development [GO:0008406]; in utero embryonic development [GO:0001701]; metanephros development [GO:0001656]; neural crest cell development [GO:0014032]; nose development [GO:0043584]; positive regulation of retinoic acid biosynthetic process [GO:1900054]; primary lung bud formation [GO:0060431]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]	NAD-retinol dehydrogenase activity [GO:0004745]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]; NAD-retinol dehydrogenase activity [GO:0004745]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; bud elongation involved in lung branching [GO:0060449]; ear development [GO:0043583]; embryonic camera-type eye development [GO:0031076]; embryonic forelimb morphogenesis [GO:0035115]; embryonic viscerocranium morphogenesis [GO:0048703]; gonad development [GO:0008406]; in utero embryonic development [GO:0001701]; metanephros development [GO:0001656]; neural crest cell development [GO:0014032]; nose development [GO:0043584]; positive regulation of retinoic acid biosynthetic process [GO:1900054]; primary lung bud formation [GO:0060431]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8IZW8	reviewed	TENS4_HUMAN	Tensin-4 (C-terminal tensin-like protein)	TNS4 CTEN PP14434	Homo sapiens (Human)	715	FUNCTION: Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}.	MISCELLANEOUS: Expression is up-regulated in tumors from a variety of tissues including lung, breast, colon, pancreas, stomach and ovary but is down-regulated in prostate cancer (PubMed:23774213, PubMed:12154022, PubMed:19487278, PubMed:24814316). In colorectal cancer cells, induces epithelial-mesenchymal transition (EMT) accompanied by down-regulation of CDH1/E-cadherin protein levels and increased cell migration (PubMed:19214987). Contributes to cell motility in colorectal cancer cells by promoting EMT through its role in the post-transcriptional stabilization of SNAIL in an SH2-dependent manner which leads to increased cell migration (PubMed:28691764). Detected in the nucleus in colon cancer cells where it interacts with CTNNB1/beta-catenin and modulates colony formation, anchorage-independent growth and cell invasiveness (PubMed:19487278, PubMed:30321615). Also detected in the nucleus in other cancer cells such as lung and cervical cancer cells where it promotes cell proliferation (PubMed:30321615). {ECO:0000269|PubMed:12154022, ECO:0000269|PubMed:19214987, ECO:0000269|PubMed:19487278, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316, ECO:0000269|PubMed:28691764, ECO:0000269|PubMed:30321615}.	protein localization [GO:0008104]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]	actin binding [GO:0003779]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; actin binding [GO:0003779]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:12154022, ECO:0000269|PubMed:17190795, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:24814316}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12154022}.
Q8IZX4	reviewed	TAF1L_HUMAN	Transcription initiation factor TFIID subunit 1-like (TAF(II)210) (TBP-associated factor 1-like) (TBP-associated factor 210 kDa) (Transcription initiation factor TFIID 210 kDa subunit)	TAF1L	Homo sapiens (Human)	1826	FUNCTION: May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced. {ECO:0000269|PubMed:12217962}.		male meiotic nuclear division [GO:0007140]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]	nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669]	DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; lysine-acetylated histone binding [GO:0070577]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; TBP-class protein binding [GO:0017025]	nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669]; DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; lysine-acetylated histone binding [GO:0070577]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; TBP-class protein binding [GO:0017025]; male meiotic nuclear division [GO:0007140]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8IZY2	reviewed	ABCA7_HUMAN	Phospholipid-transporting ATPase ABCA7 (EC 7.6.2.1) (ABCA-SSN) (ATP-binding cassette sub-family A member 7) (Autoantigen SS-N) (Macrophage ABC transporter)	ABCA7	Homo sapiens (Human)	2146	FUNCTION: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). {ECO:0000250|UniProtKB:Q91V24, ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:26260791}.	MISCELLANEOUS: [Isoform 2]: Inactive for apoA-I-mediated lipid release. {ECO:0000305}.	amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta formation [GO:0034205]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; cholesterol efflux [GO:0033344]; high-density lipoprotein particle assembly [GO:0034380]; memory [GO:0007613]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of endocytosis [GO:0045806]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; peptide cross-linking [GO:0018149]; phagocytosis [GO:0006909]; phospholipid efflux [GO:0033700]; phospholipid translocation [GO:0045332]; plasma membrane raft organization [GO:0044857]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of engulfment of apoptotic cell [GO:1901076]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to nucleus [GO:0034504]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of lipid metabolic process [GO:0019216]; visual learning [GO:0008542]	cell junction [GO:0030054]; cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; glial cell projection [GO:0097386]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	ABC-type transporter activity [GO:0140359]; apolipoprotein A-I receptor activity [GO:0034188]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transporter activity [GO:0005548]	cell junction [GO:0030054]; cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; glial cell projection [GO:0097386]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; ABC-type transporter activity [GO:0140359]; apolipoprotein A-I receptor activity [GO:0034188]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transporter activity [GO:0005548]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta formation [GO:0034205]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; cholesterol efflux [GO:0033344]; high-density lipoprotein particle assembly [GO:0034380]; memory [GO:0007613]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of endocytosis [GO:0045806]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; peptide cross-linking [GO:0018149]; phagocytosis [GO:0006909]; phospholipid efflux [GO:0033700]; phospholipid translocation [GO:0045332]; plasma membrane raft organization [GO:0044857]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of engulfment of apoptotic cell [GO:1901076]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to nucleus [GO:0034504]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of lipid metabolic process [GO:0019216]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:14592415}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q91V24}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q91V24}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q91V24}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q91V24}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q91V24}. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney (By similarity). {ECO:0000250|UniProtKB:Q91V24}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:14592415}. Endoplasmic reticulum {ECO:0000269|PubMed:14592415}. Note=May localize to the endoplasmic reticulum. {ECO:0000269|PubMed:14592415}.
Q8J025	reviewed	APCD1_HUMAN	Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein)	APCDD1 DRAPC1 FP7019	Homo sapiens (Human)	514	FUNCTION: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis. {ECO:0000269|PubMed:12384519, ECO:0000269|PubMed:20393562}.		astrocyte cell migration [GO:0043615]; hair follicle development [GO:0001942]; negative regulation of Wnt signaling pathway [GO:0030178]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; Wnt signaling pathway [GO:0016055]	plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; Wnt-protein binding [GO:0017147]	plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; Wnt-protein binding [GO:0017147]; astrocyte cell migration [GO:0043615]; hair follicle development [GO:0001942]; negative regulation of Wnt signaling pathway [GO:0030178]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20393562}; Single-pass type I membrane protein {ECO:0000269|PubMed:20393562}.
Q8N0S2	reviewed	SYCE1_HUMAN	Synaptonemal complex central element protein 1 (Cancer/testis antigen 76) (CT76)	SYCE1 C10orf94	Homo sapiens (Human)	351	FUNCTION: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. {ECO:0000250|UniProtKB:Q9D495}.		cell division [GO:0051301]; synaptonemal complex assembly [GO:0007130]	central element [GO:0000801]; chromosome [GO:0005694]; synaptonemal complex [GO:0000795]		central element [GO:0000801]; chromosome [GO:0005694]; synaptonemal complex [GO:0000795]; cell division [GO:0051301]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D495}. Chromosome {ECO:0000250|UniProtKB:Q9D495}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements. {ECO:0000250|UniProtKB:Q9D495}.
Q8N0S6	reviewed	CENPL_HUMAN	Centromere protein L (CENP-L) (Interphase centromere complex protein 33)	CENPL C1orf155 ICEN33	Homo sapiens (Human)	344	FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:16716197}.		chromosome segregation [GO:0007059]	cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromosome segregation [GO:0007059]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16716197}. Chromosome, centromere {ECO:0000269|PubMed:16716197}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Q8N0U8	reviewed	VKORL_HUMAN	Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1-like protein 1) (EC 1.17.4.4)	VKORC1L1	Homo sapiens (Human)	176	FUNCTION: Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K, and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins. {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:23928358, ECO:0000269|PubMed:24532791}.		cellular response to oxidative stress [GO:0034599]; peptidyl-glutamic acid carboxylation [GO:0017187]; vitamin K metabolic process [GO:0042373]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	quinone binding [GO:0048038]; vitamin-K-epoxide reductase (warfarin-sensitive) activity [GO:0047057]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; quinone binding [GO:0048038]; vitamin-K-epoxide reductase (warfarin-sensitive) activity [GO:0047057]; cellular response to oxidative stress [GO:0034599]; peptidyl-glutamic acid carboxylation [GO:0017187]; vitamin K metabolic process [GO:0042373]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:24532791}; Multi-pass membrane protein {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:24532791}.
Q8N0V3	reviewed	RBFA_HUMAN	Putative ribosome-binding factor A, mitochondrial	RBFA C18orf22	Homo sapiens (Human)	343			rRNA processing [GO:0006364]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q8N0V5	reviewed	GNT2A_HUMAN	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (N-acetylglucosaminyltransferase) (EC 2.4.1.150) (I-branching enzyme) (IGNT)	GCNT2 GCNT5 II NACGT1	Homo sapiens (Human)	402	FUNCTION: Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. {ECO:0000269|PubMed:7579796, ECO:0000269|PubMed:8449405}.; FUNCTION: [Isoform C]: Determines the expression of the blood group I antigen in erythrocytes. {ECO:0000269|PubMed:12468428}.		glycosaminoglycan biosynthetic process [GO:0006024]; maintenance of lens transparency [GO:0036438]; multicellular organism development [GO:0007275]; negative regulation of cell-substrate adhesion [GO:0010812]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; post-transcriptional regulation of gene expression [GO:0010608]; protein glycosylation [GO:0006486]; transforming growth factor beta receptor signaling pathway [GO:0007179]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	acetylglucosaminyltransferase activity [GO:0008375]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; acetylglucosaminyltransferase activity [GO:0008375]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]; glycosaminoglycan biosynthetic process [GO:0006024]; maintenance of lens transparency [GO:0036438]; multicellular organism development [GO:0007275]; negative regulation of cell-substrate adhesion [GO:0010812]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; post-transcriptional regulation of gene expression [GO:0010608]; protein glycosylation [GO:0006486]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q8N0W3	reviewed	FCSK_HUMAN	L-fucose kinase (Fucokinase) (EC 2.7.1.52)	FCSK FUK	Homo sapiens (Human)	1084	FUNCTION: Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides. {ECO:0000269|PubMed:30503518}.		carbohydrate phosphorylation [GO:0046835]; GDP-L-fucose salvage [GO:0042352]; response to dopamine [GO:1903350]	cytosol [GO:0005829]	ATP binding [GO:0005524]; fucokinase activity [GO:0050201]	cytosol [GO:0005829]; ATP binding [GO:0005524]; fucokinase activity [GO:0050201]; carbohydrate phosphorylation [GO:0046835]; GDP-L-fucose salvage [GO:0042352]; response to dopamine [GO:1903350]	
Q8N0W4	reviewed	NLGNX_HUMAN	Neuroligin-4, X-linked (Neuroligin X) (HNLX)	NLGN4X KIAA1260 NLGN4 UNQ365/PRO701	Homo sapiens (Human)	816	FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. {ECO:0000269|PubMed:18093521}.		adult behavior [GO:0030534]; brainstem development [GO:0003360]; cell-cell junction organization [GO:0045216]; cerebellum development [GO:0021549]; chemical synaptic transmission [GO:0007268]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of excitatory postsynaptic potential [GO:0090394]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; organ growth [GO:0035265]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; social behavior [GO:0035176]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488]; vocalization behavior [GO:0071625]	asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; dendrite [GO:0030425]; excitatory synapse [GO:0060076]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]	cell adhesion molecule binding [GO:0050839]; chloride ion binding [GO:0031404]; neurexin family protein binding [GO:0042043]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]	asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; dendrite [GO:0030425]; excitatory synapse [GO:0060076]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]; cell adhesion molecule binding [GO:0050839]; chloride ion binding [GO:0031404]; neurexin family protein binding [GO:0042043]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]; adult behavior [GO:0030534]; brainstem development [GO:0003360]; cell-cell junction organization [GO:0045216]; cerebellum development [GO:0021549]; chemical synaptic transmission [GO:0007268]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of excitatory postsynaptic potential [GO:0090394]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; organ growth [GO:0035265]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; social behavior [GO:0035176]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Postsynaptic density membrane.
Q8N0X2	reviewed	SPG16_HUMAN	Sperm-associated antigen 16 protein (Pf20 protein homolog)	SPAG16 PF20	Homo sapiens (Human)	631	FUNCTION: Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity). {ECO:0000250|UniProtKB:Q8K450}.		axoneme assembly [GO:0035082]; cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; mucociliary clearance [GO:0120197]; sperm axoneme assembly [GO:0007288]	axonemal central apparatus [GO:1990716]; axoneme [GO:0005930]; extracellular region [GO:0005576]; sperm flagellum [GO:0036126]		axonemal central apparatus [GO:1990716]; axoneme [GO:0005930]; extracellular region [GO:0005576]; sperm flagellum [GO:0036126]; axoneme assembly [GO:0035082]; cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; mucociliary clearance [GO:0120197]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8K450}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q8K450}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q8K450}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8K450}. Note=Detected on the sperm flagellum axoneme. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules (By similarity). {ECO:0000250|UniProtKB:Q8K450}.
Q8N0X4	reviewed	CLYBL_HUMAN	Citramalyl-CoA lyase, mitochondrial (EC 4.1.3.25) ((3S)-malyl-CoA thioesterase) (EC 3.1.2.30) (Beta-methylmalate synthase) (EC 2.3.3.-) (Citrate lyase subunit beta-like protein) (Citrate lyase beta-like) (Malate synthase) (EC 2.3.3.9)	CLYBL CLB	Homo sapiens (Human)	340	FUNCTION: Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:29056341, PubMed:24334609). Also displays malyl-CoA thioesterase activity (PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341). {ECO:0000269|PubMed:24334609, ECO:0000269|PubMed:29056341}.		positive regulation of cobalamin metabolic process [GO:0106121]; protein homotrimerization [GO:0070207]; regulation of cobalamin metabolic process [GO:0106064]	mitochondrion [GO:0005739]	(S)-citramalyl-CoA lyase activity [GO:0047777]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; malate synthase activity [GO:0004474]	mitochondrion [GO:0005739]; (S)-citramalyl-CoA lyase activity [GO:0047777]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; malate synthase activity [GO:0004474]; positive regulation of cobalamin metabolic process [GO:0106121]; protein homotrimerization [GO:0070207]; regulation of cobalamin metabolic process [GO:0106064]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8R4N0}.
Q8N0X7	reviewed	SPART_HUMAN	Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1)	SPART KIAA0610 SPG20 TAHCCP1	Homo sapiens (Human)	666	FUNCTION: May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964). {ECO:0000269|PubMed:20719964}.		abscission [GO:0009838]; adipose tissue development [GO:0060612]; BMP signaling pathway [GO:0030509]; cell division [GO:0051301]; collateral sprouting in absence of injury [GO:0048669]; lipid droplet organization [GO:0034389]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of collateral sprouting in absence of injury [GO:0048698]; neuromuscular process [GO:0050905]; regulation of mitochondrial membrane potential [GO:0051881]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; midbody [GO:0030496]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; synapse [GO:0045202]	ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; midbody [GO:0030496]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; synapse [GO:0045202]; ubiquitin protein ligase binding [GO:0031625]; abscission [GO:0009838]; adipose tissue development [GO:0060612]; BMP signaling pathway [GO:0030509]; cell division [GO:0051301]; collateral sprouting in absence of injury [GO:0048669]; lipid droplet organization [GO:0034389]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of collateral sprouting in absence of injury [GO:0048698]; neuromuscular process [GO:0050905]; regulation of mitochondrial membrane potential [GO:0051881]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19580544}. Midbody {ECO:0000269|PubMed:20719964}. Note=Transiently associated with endosomes (PubMed:19580544). Colocalized with IST1 to the ends of Flemming bodies during cytokinesis (PubMed:20719964). {ECO:0000269|PubMed:19580544, ECO:0000269|PubMed:20719964}.
Q8N0Y2	reviewed	ZN444_HUMAN	Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17)	ZNF444 EZF2 ZSCAN17	Homo sapiens (Human)	327	FUNCTION: Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q8N0Z3	reviewed	SPICE_HUMAN	Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein)	SPICE1 CCDC52 SPICE	Homo sapiens (Human)	855	FUNCTION: Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}.		cell division [GO:0051301]; metaphase chromosome alignment [GO:0051310]; mitotic spindle assembly [GO:0090307]; regulation of centriole replication [GO:0046599]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle [GO:0005819]		centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle [GO:0005819]; cell division [GO:0051301]; metaphase chromosome alignment [GO:0051310]; mitotic spindle assembly [GO:0090307]; regulation of centriole replication [GO:0046599]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:20736305}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20736305}.
Q8N0Z6	reviewed	TTC5_HUMAN	Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Protein Strap)	TTC5	Homo sapiens (Human)	440	FUNCTION: Cofactor involved in the regulation of various cellular mechanisms such as actin regulation, autophagy, chromatin regulation and DNA repair (PubMed:18451878, PubMed:31727855). In non-stress conditions, interacts with cofactor JMY in the cytoplasm which prevents JMY's actin nucleation activity and ability to activate the Arp2/3 complex. Acts as a negative regulator of nutrient stress-induced autophagy by preventing JMY's interaction with MAP1LC3B, thereby preventing autophagosome formation (By similarity). Involves in tubulin autoregulation by promoting its degradation in response to excess soluble tubulin (PubMed:31727855). To do so, associates with the active ribosome near the ribosome exit tunnel and with nascent tubulin polypeptides early during their translation, triggering tubulin mRNA-targeted degradation (PubMed:31727855). Following DNA damage, phosphorylated by DNA damage responsive protein kinases ATM and CHEK2, leading to its nuclear accumulation and stability. Nuclear TTC5/STRAP promotes the assembly of a stress-responsive p53/TP53 coactivator complex, which includes the coactivators JMY and p300, thereby increasing p53/TP53-dependent transcription and apoptosis. Also recruits arginine methyltransferase PRMT5 to p53/TP53 when DNA is damaged, allowing PRMT5 to methylate p53/TP53. In DNA stress conditions, also prevents p53/TP53 degradation by E3 ubiquitin ligase MDM2 (By similarity). Upon heat-shock stress, forms a chromatin-associated complex with heat-shock factor 1 HSF1 and p300/EP300 to stimulate heat-shock-responsive transcription, thereby increasing cell survival (PubMed:18451878). Mitochondrial TTC5/STRAP interacts with ATP synthase subunit beta ATP5F1B which decreased ATP synthase activity and lowers mitochondrial ATP production, thereby regulating cellular respiration and mitochondrial-dependent apoptosis. Mitochondrial TTC5/STRAP also regulates p53/TP53-mediated apoptosis (By similarity). {ECO:0000250|UniProtKB:Q99LG4, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:31727855}.		cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; ribosome binding [GO:0043022]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; ribosome binding [GO:0043022]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99LG4}. Cytoplasm {ECO:0000269|PubMed:31727855}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q99LG4}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q99LG4}. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. Nuclear localization may be necessary for DNA damage-dependent stabilization of the protein. {ECO:0000250|UniProtKB:Q99LG4}.
Q8N100	reviewed	ATOH7_HUMAN	Transcription factor ATOH7 (Atonal bHLH transcription factor 7) (Class A basic helix-loop-helix protein 13) (bHLHa13) (Protein atonal homolog 7)	ATOH7 ATH5 BHLHA13	Homo sapiens (Human)	152	FUNCTION: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (PubMed:31696227). Dimerization with TCF3 isoform E47 may be required in certain situations (PubMed:31696227). Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes (By similarity). Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract (By similarity). Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription (By similarity). Required for retinal circadian rhythm photoentrainment (By similarity). Plays a role in brainstem auditory signaling and binaural processing (By similarity). {ECO:0000250|UniProtKB:Q9Z2E5, ECO:0000269|PubMed:31696227}.		axon development [GO:0061564]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; neural retina development [GO:0003407]; neuron fate commitment [GO:0048663]; optic nerve development [GO:0021554]; positive regulation of retinal ganglion cell axon guidance [GO:1902336]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to auditory stimulus [GO:0010996]; sensory organ development [GO:0007423]	axon [GO:0030424]; chromatin [GO:0000785]; nucleus [GO:0005634]; perikaryon [GO:0043204]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	axon [GO:0030424]; chromatin [GO:0000785]; nucleus [GO:0005634]; perikaryon [GO:0043204]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; axon development [GO:0061564]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; neural retina development [GO:0003407]; neuron fate commitment [GO:0048663]; optic nerve development [GO:0021554]; positive regulation of retinal ganglion cell axon guidance [GO:1902336]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to auditory stimulus [GO:0010996]; sensory organ development [GO:0007423]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31696227}. Perikaryon {ECO:0000250|UniProtKB:Q9Z2E5}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2E5}.
Q8N104	reviewed	D106A_HUMAN	Beta-defensin 106 (Beta-defensin 6) (BD-6) (DEFB-6) (Defensin, beta 106)	DEFB106A BD6 DEFB106 DEFB6; DEFB106B	Homo sapiens (Human)	65	FUNCTION: Has antibacterial activity (PubMed:12600824). Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:23938203). {ECO:0000269|PubMed:12600824, ECO:0000269|PubMed:23938203}.		antifungal innate immune response [GO:0061760]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]	membrane [GO:0016020]; microvesicle [GO:1990742]; nucleus [GO:0005634]	CCR2 chemokine receptor binding [GO:0031727]; heparin binding [GO:0008201]; lipopolysaccharide binding [GO:0001530]	membrane [GO:0016020]; microvesicle [GO:1990742]; nucleus [GO:0005634]; CCR2 chemokine receptor binding [GO:0031727]; heparin binding [GO:0008201]; lipopolysaccharide binding [GO:0001530]; antifungal innate immune response [GO:0061760]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Membrane {ECO:0000269|PubMed:23938203}. Note=Associates with tumor cell membrane-derived microvesicles (PubMed:23938203). {ECO:0000269|PubMed:23938203}.
Q8N108	reviewed	MIER1_HUMAN	Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1)	MIER1 KIAA1610	Homo sapiens (Human)	512	FUNCTION: Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}.	MISCELLANEOUS: [Isoform 2]: It is uncertain whether Met-1 or Met-55 is the initiator. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: It is uncertain whether Met-1 or Met-55 is the initiator. {ECO:0000305}.	chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of DNA-templated transcription [GO:0006355]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053]	histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053]; histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm.
Q8N114	reviewed	SHSA5_HUMAN	Protein shisa-5 (Putative NF-kappa-B-activating protein 120) (Scotin)	SHISA5 SCOTIN PSEC0133	Homo sapiens (Human)	240	FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. {ECO:0000269|PubMed:12135983}.		intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]	WW domain binding [GO:0050699]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]; WW domain binding [GO:0050699]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12135983}; Single-pass type I membrane protein {ECO:0000269|PubMed:12135983}. Nucleus membrane {ECO:0000269|PubMed:12135983}.
Q8N119	reviewed	MMP21_HUMAN	Matrix metalloproteinase-21 (MMP-21) (EC 3.4.24.-)	MMP21	Homo sapiens (Human)	569	FUNCTION: Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721). {ECO:0000269|PubMed:12617721, ECO:0000269|PubMed:26429889, ECO:0000269|PubMed:26437028}.		collagen catabolic process [GO:0030574]; coronary vasculature development [GO:0060976]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right symmetry [GO:0007368]; extracellular matrix organization [GO:0030198]; hematopoietic progenitor cell differentiation [GO:0002244]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; collagen catabolic process [GO:0030574]; coronary vasculature development [GO:0060976]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right symmetry [GO:0007368]; extracellular matrix organization [GO:0030198]; hematopoietic progenitor cell differentiation [GO:0002244]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N122	reviewed	RPTOR_HUMAN	Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)	RPTOR KIAA1303 RAPTOR	Homo sapiens (Human)	1335	FUNCTION: Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715}.		cellular response to amino acid stimulus [GO:0071230]; cellular response to hypoxia [GO:0071456]; cellular response to leucine [GO:0071233]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; negative regulation of autophagy [GO:0010507]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of autophagy [GO:0010506]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; TORC1 complex [GO:0031931]	14-3-3 protein binding [GO:0071889]; enzyme-substrate adaptor activity [GO:0140767]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; small GTPase binding [GO:0031267]; TFIIIC-class transcription factor complex binding [GO:0001156]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; TORC1 complex [GO:0031931]; 14-3-3 protein binding [GO:0071889]; enzyme-substrate adaptor activity [GO:0140767]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; small GTPase binding [GO:0031267]; TFIIIC-class transcription factor complex binding [GO:0001156]; cellular response to amino acid stimulus [GO:0071230]; cellular response to hypoxia [GO:0071456]; cellular response to leucine [GO:0071233]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; negative regulation of autophagy [GO:0010507]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of autophagy [GO:0010506]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764}. Cytoplasm {ECO:0000269|PubMed:20381137}. Cytoplasmic granule {ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:25940091}. Note=Targeting to lysosomes depends on amino acid availability: recruited to lysosome membranes via interaction with GTP-bound form of RagA/RRAGA (or RagB/RRAGB) in complex with the GDP-bound form of RagC/RRAGC (or RagD/RRAGD), promoting recruitment of mTORC1 to the lysosomes (PubMed:31601764, PubMed:31601708). In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased (PubMed:23953116). {ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764}.
Q8N126	reviewed	CADM3_HUMAN	Cell adhesion molecule 3 (Brain immunoglobulin receptor) (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (SynCAM3) (TSLC1-like protein 1) (TSLL1)	CADM3 IGSF4B NECL1 SYNCAM3 TSLL1 UNQ225/PRO258	Homo sapiens (Human)	398	FUNCTION: Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). {ECO:0000250}.		heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]	protein homodimerization activity [GO:0042803]	cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q99N28}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q99N28}. Cell junction {ECO:0000250|UniProtKB:Q99N28}.
Q8N130	reviewed	NPT2C_HUMAN	Sodium-dependent phosphate transport protein 2C (Sodium-phosphate transport protein 2C) (Na(+)-dependent phosphate cotransporter 2C) (Sodium/inorganic phosphate cotransporter IIC) (Sodium/phosphate cotransporter 2C) (Na(+)/Pi cotransporter 2C) (NaPi-2c) (Solute carrier family 34 member 3)	SLC34A3 NPT2C NPTIIC	Homo sapiens (Human)	599	FUNCTION: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:11880379). The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (By similarity). {ECO:0000250|UniProtKB:Q80SU6, ECO:0000269|PubMed:11880379}.		intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transport [GO:0006817]; sodium ion transport [GO:0006814]; sodium-dependent phosphate transport [GO:0044341]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	sodium:phosphate symporter activity [GO:0005436]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; sodium:phosphate symporter activity [GO:0005436]; intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transport [GO:0006817]; sodium ion transport [GO:0006814]; sodium-dependent phosphate transport [GO:0044341]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q8K4R8}; Multi-pass membrane protein {ECO:0000255}. Note=ocalized at the brush border membrane in the kidney. {ECO:0000250|UniProtKB:Q8K4R8}.
Q8N131	reviewed	PORIM_HUMAN	Porimin (Keratinocytes-associated transmembrane protein 3) (KCT-3) (Pro-oncosis receptor inducing membrane injury) (Transmembrane protein 123)	TMEM123 KCT3 PSEC0111 UNQ641/PRO1271	Homo sapiens (Human)	208	FUNCTION: Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. {ECO:0000269|PubMed:11481458}.			cytoplasmic vesicle [GO:0031410]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]	signaling receptor activity [GO:0038023]	cytoplasmic vesicle [GO:0031410]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; signaling receptor activity [GO:0038023]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8N135	reviewed	LGI4_HUMAN	Leucine-rich repeat LGI family member 4 (LGI1-like protein 3) (Leucine-rich glioma-inactivated protein 4)	LGI4 LGIL3 UNQ6515/PRO21485	Homo sapiens (Human)	537	FUNCTION: Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity). {ECO:0000250|UniProtKB:Q8K1S1}.		adult locomotory behavior [GO:0008344]; glial cell proliferation [GO:0014009]; myelination in peripheral nervous system [GO:0022011]; neuron maturation [GO:0042551]; regulation of myelination [GO:0031641]	extracellular region [GO:0005576]; extracellular space [GO:0005615]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; adult locomotory behavior [GO:0008344]; glial cell proliferation [GO:0014009]; myelination in peripheral nervous system [GO:0022011]; neuron maturation [GO:0042551]; regulation of myelination [GO:0031641]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N136	reviewed	DAW1_HUMAN	Dynein assembly factor with WD repeat domains 1 (Outer row dynein assembly protein 16 homolog) (WD repeat-containing protein 69)	DAW1 ODA16 WDR69	Homo sapiens (Human)	415	FUNCTION: Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis (PubMed:36074124). Facilitates the onset of robust cilia motility during development (PubMed:36074124). {ECO:0000269|PubMed:36074124}.		cerebrospinal fluid circulation [GO:0090660]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intraciliary transport [GO:0042073]; outer dynein arm assembly [GO:0036158]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; SCF ubiquitin ligase complex [GO:0019005]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; cerebrospinal fluid circulation [GO:0090660]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intraciliary transport [GO:0042073]; outer dynein arm assembly [GO:0036158]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250|UniProtKB:Q3Y8L7}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q3Y8L7}. Note=Expression is concentrated at the flagellum basal body but is also detected along the length of the flagellum. {ECO:0000250|UniProtKB:Q3Y8L7}.
Q8N137	reviewed	CNTRB_HUMAN	Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8)	CNTROB LIP8 PP1221	Homo sapiens (Human)	903	FUNCTION: Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. {ECO:0000269|PubMed:16275750}.		centriole replication [GO:0007099]; centrosome separation [GO:0051299]; mitotic cytokinetic process [GO:1902410]; regulation of cilium assembly [GO:1902017]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]	protein domain specific binding [GO:0019904]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; protein domain specific binding [GO:0019904]; centriole replication [GO:0007099]; centrosome separation [GO:0051299]; mitotic cytokinetic process [GO:1902410]; regulation of cilium assembly [GO:1902017]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:16275750}. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.
Q8N138	reviewed	ORML3_HUMAN	ORM1-like protein 3	ORMDL3	Homo sapiens (Human)	153	FUNCTION: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505, PubMed:30700557, PubMed:37308477). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (PubMed:37308477). {ECO:0000269|PubMed:20182505, ECO:0000269|PubMed:30700557, ECO:0000269|PubMed:37308477}.		ceramide metabolic process [GO:0006672]; intracellular sphingolipid homeostasis [GO:0090156]; motor behavior [GO:0061744]; myelination [GO:0042552]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of ceramide biosynthetic process [GO:1900060]; positive regulation of autophagy [GO:0010508]; positive regulation of protein localization to nucleus [GO:1900182]; regulation of smooth muscle contraction [GO:0006940]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; SPOTS complex [GO:0035339]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; SPOTS complex [GO:0035339]; ceramide metabolic process [GO:0006672]; intracellular sphingolipid homeostasis [GO:0090156]; motor behavior [GO:0061744]; myelination [GO:0042552]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of ceramide biosynthetic process [GO:1900060]; positive regulation of autophagy [GO:0010508]; positive regulation of protein localization to nucleus [GO:1900182]; regulation of smooth muscle contraction [GO:0006940]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12093374, ECO:0000269|PubMed:19819884}; Multi-pass membrane protein {ECO:0000269|PubMed:12093374, ECO:0000269|PubMed:19819884, ECO:0000269|PubMed:33558762}.
Q8N139	reviewed	ABCA6_HUMAN	ATP-binding cassette sub-family A member 6 (EC 7.6.2.-)	ABCA6	Homo sapiens (Human)	1617	FUNCTION: Probable transporter which may play a role in macrophage lipid transport and homeostasis. {ECO:0000305|PubMed:10639163}.		lipid transport [GO:0006869]	Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]	Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:24028821}; Multi-pass membrane protein {ECO:0000305}.
Q8N140	reviewed	EID3_HUMAN	EP300-interacting inhibitor of differentiation 3 (EID-3) (E1A-like inhibitor of differentiation 3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B)	EID3	Homo sapiens (Human)	333	FUNCTION: Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. {ECO:0000269|PubMed:15987788}.; FUNCTION: Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors. {ECO:0000269|PubMed:15987788}.		chromatin looping [GO:0140588]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]		chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]; chromatin looping [GO:0140588]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15987788}. Cytoplasm {ECO:0000269|PubMed:15987788}. Chromosome, telomere {ECO:0000305|PubMed:15987788}. Note=May shuttle between nucleus and cytoplasm. {ECO:0000269|PubMed:15987788}.
Q8N142	reviewed	PURA1_HUMAN	Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M-type adenylosuccinate synthetase) (Adenylosuccinate synthetase-like 1) (AdSSL1) (IMP--aspartate ligase 1)	ADSS1 ADSSL1	Homo sapiens (Human)	457	FUNCTION: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. {ECO:0000269|PubMed:26506222}.		'de novo' AMP biosynthetic process [GO:0044208]; AMP biosynthetic process [GO:0006167]; aspartate metabolic process [GO:0006531]; cellular response to electrical stimulus [GO:0071257]; cellular response to xenobiotic stimulus [GO:0071466]; glutamine metabolic process [GO:0006541]; immune system process [GO:0002376]; IMP metabolic process [GO:0046040]; response to muscle activity [GO:0014850]; response to starvation [GO:0042594]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	actin filament binding [GO:0051015]; adenylosuccinate synthase activity [GO:0004019]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; actin filament binding [GO:0051015]; adenylosuccinate synthase activity [GO:0004019]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301]; 'de novo' AMP biosynthetic process [GO:0044208]; AMP biosynthetic process [GO:0006167]; aspartate metabolic process [GO:0006531]; cellular response to electrical stimulus [GO:0071257]; cellular response to xenobiotic stimulus [GO:0071466]; glutamine metabolic process [GO:0006541]; immune system process [GO:0002376]; IMP metabolic process [GO:0046040]; response to muscle activity [GO:0014850]; response to starvation [GO:0042594]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03126, ECO:0000269|PubMed:15786719}.
Q8N144	reviewed	CXD3_HUMAN	Gap junction delta-3 protein (Connexin-31.9) (Cx31.9) (Gap junction alpha-11 protein) (Gap junction chi-1 protein)	GJD3 GJA11 GJC1	Homo sapiens (Human)	294	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.		cell communication [GO:0007154]; cell-cell signaling [GO:0007267]; gap junction assembly [GO:0016264]; negative regulation of cardiac conduction [GO:1903780]; negative regulation of heart rate [GO:0010459]; response to glucose [GO:0009749]	cell surface [GO:0009986]; connexin complex [GO:0005922]; plasma membrane [GO:0005886]	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling [GO:0086077]; monoatomic ion channel activity [GO:0005216]	cell surface [GO:0009986]; connexin complex [GO:0005922]; plasma membrane [GO:0005886]; gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling [GO:0086077]; monoatomic ion channel activity [GO:0005216]; cell communication [GO:0007154]; cell-cell signaling [GO:0007267]; gap junction assembly [GO:0016264]; negative regulation of cardiac conduction [GO:1903780]; negative regulation of heart rate [GO:0010459]; response to glucose [GO:0009749]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12154091}; Multi-pass membrane protein {ECO:0000269|PubMed:12154091}. Cell junction, gap junction {ECO:0000269|PubMed:12154091}.
Q8N145	reviewed	LGI3_HUMAN	Leucine-rich repeat LGI family member 3 (LGI1-like protein 4) (Leucine-rich glioma-inactivated protein 3)	LGI3 LGIL4 UNQ8190/PRO23199	Homo sapiens (Human)	548	FUNCTION: May participate in the regulation of neuronal exocytosis. {ECO:0000250}.		exocytosis [GO:0006887]; regulation of exocytosis [GO:0017157]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; juxtaparanode region of axon [GO:0044224]; synaptic vesicle [GO:0008021]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; juxtaparanode region of axon [GO:0044224]; synaptic vesicle [GO:0008021]; exocytosis [GO:0006887]; regulation of exocytosis [GO:0017157]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:35948005}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q8K406}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q8K406}. Cell projection, axon {ECO:0000250|UniProtKB:Q8K406}. Note=Found in the synaptosomal membrane fraction. Within peripheral myelinated axons, LGI3 is highly expressed at the juxtaparanodal membrane and colocalizes with the voltage-gated potassium channels Kv1.1 (KCNA1) and Kv1.2 (KCNA2), and with CNTNAP2, DLG4, ADAM22 and ADAM23 (By similarity). {ECO:0000250|UniProtKB:Q8K406}.
Q8N149	reviewed	LIRA2_HUMAN	Leukocyte immunoglobulin-like receptor subfamily A member 2 (CD85 antigen-like family member H) (Immunoglobulin-like transcript 1) (ILT-1) (Leukocyte immunoglobulin-like receptor 7) (LIR-7) (CD antigen CD85h)	LILRA2 ILT1 LIR7	Homo sapiens (Human)	483	FUNCTION: Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061). {ECO:0000269|PubMed:12529506, ECO:0000269|PubMed:19230061, ECO:0000269|PubMed:22479404, ECO:0000269|PubMed:27572839}.		cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; innate immune response [GO:0045087]; innate immune response activating cell surface receptor signaling pathway [GO:0002220]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; neutrophil activation involved in immune response [GO:0002283]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell activation [GO:0050867]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of tumor necrosis factor production [GO:0032760]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]; IgM binding [GO:0001791]; inhibitory MHC class I receptor activity [GO:0032396]; signaling receptor activity [GO:0038023]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; IgM binding [GO:0001791]; inhibitory MHC class I receptor activity [GO:0032396]; signaling receptor activity [GO:0038023]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; innate immune response [GO:0045087]; innate immune response activating cell surface receptor signaling pathway [GO:0002220]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; neutrophil activation involved in immune response [GO:0002283]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell activation [GO:0050867]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of tumor necrosis factor production [GO:0032760]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12529506, ECO:0000269|PubMed:22479404, ECO:0000269|PubMed:27572839}; Single-pass type I membrane protein {ECO:0000305|PubMed:12529506, ECO:0000305|PubMed:22479404}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000303|PubMed:19658091}.
Q8N157	reviewed	AHI1_HUMAN	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1)	AHI1	Homo sapiens (Human)	1196	FUNCTION: Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). {ECO:0000250|UniProtKB:Q8K3E5, ECO:0000269|PubMed:21623382}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	central nervous system development [GO:0007417]; cilium assembly [GO:0060271]; cloaca development [GO:0035844]; heart looping [GO:0001947]; hindbrain development [GO:0030902]; Kupffer's vesicle development [GO:0070121]; left/right axis specification [GO:0070986]; morphogenesis of a polarized epithelium [GO:0001738]; motile cilium assembly [GO:0044458]; negative regulation of apoptotic process [GO:0043066]; otic vesicle development [GO:0071599]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of polarized epithelial cell differentiation [GO:0030862]; positive regulation of receptor internalization [GO:0002092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephric duct morphogenesis [GO:0039023]; pronephric nephron tubule morphogenesis [GO:0039008]; protein localization [GO:0008104]; regulation of behavior [GO:0050795]; retina layer formation [GO:0010842]; specification of axis polarity [GO:0065001]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vesicle-mediated transport [GO:0016192]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; MKS complex [GO:0036038]; non-motile cilium [GO:0097730]	identical protein binding [GO:0042802]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; MKS complex [GO:0036038]; non-motile cilium [GO:0097730]; identical protein binding [GO:0042802]; central nervous system development [GO:0007417]; cilium assembly [GO:0060271]; cloaca development [GO:0035844]; heart looping [GO:0001947]; hindbrain development [GO:0030902]; Kupffer's vesicle development [GO:0070121]; left/right axis specification [GO:0070986]; morphogenesis of a polarized epithelium [GO:0001738]; motile cilium assembly [GO:0044458]; negative regulation of apoptotic process [GO:0043066]; otic vesicle development [GO:0071599]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of polarized epithelial cell differentiation [GO:0030862]; positive regulation of receptor internalization [GO:0002092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephric duct morphogenesis [GO:0039023]; pronephric nephron tubule morphogenesis [GO:0039008]; protein localization [GO:0008104]; regulation of behavior [GO:0050795]; retina layer formation [GO:0010842]; specification of axis polarity [GO:0065001]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:21623382, ECO:0000269|PubMed:23532844}. Cell junction, adherens junction {ECO:0000269|PubMed:18633336, ECO:0000269|PubMed:23532844}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8K3E5}. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium. {ECO:0000250|UniProtKB:Q8K3E5}.
Q8N158	reviewed	GPC2_HUMAN	Glypican-2 [Cleaved into: Secreted glypican-2]	GPC2	Homo sapiens (Human)	579	FUNCTION: Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity). {ECO:0000250}.		cell migration [GO:0016477]; neuron differentiation [GO:0030182]; positive regulation of neuron projection development [GO:0010976]; regulation of protein localization to membrane [GO:1905475]; regulation of signal transduction [GO:0009966]; smoothened signaling pathway [GO:0007224]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]		cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]; cell migration [GO:0016477]; neuron differentiation [GO:0030182]; positive regulation of neuron projection development [GO:0010976]; regulation of protein localization to membrane [GO:1905475]; regulation of signal transduction [GO:0009966]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.; SUBCELLULAR LOCATION: [Secreted glypican-2]: Secreted, extracellular space {ECO:0000250}.
Q8N159	reviewed	NAGS_HUMAN	N-acetylglutamate synthase, mitochondrial (EC 2.3.1.1) (Amino-acid acetyltransferase) [Cleaved into: N-acetylglutamate synthase long form; N-acetylglutamate synthase short form; N-acetylglutamate synthase conserved domain form]	NAGS	Homo sapiens (Human)	534	FUNCTION: Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. {ECO:0000269|PubMed:12459178, ECO:0000269|PubMed:23894642, ECO:0000269|PubMed:7126172}.		arginine biosynthetic process [GO:0006526]; glutamate metabolic process [GO:0006536]; urea cycle [GO:0000050]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	acetyl-CoA:L-glutamate N-acetyltransferase activity [GO:0004042]; methione N-acyltransferase activity [GO:0103045]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; acetyl-CoA:L-glutamate N-acetyltransferase activity [GO:0004042]; methione N-acyltransferase activity [GO:0103045]; arginine biosynthetic process [GO:0006526]; glutamate metabolic process [GO:0006536]; urea cycle [GO:0000050]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:7126172}.
Q8N163	reviewed	CCAR2_HUMAN	Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC)	CCAR2 DBC1 KIAA1967	Homo sapiens (Human)	923	FUNCTION: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}.		cell cycle [GO:0007049]; DNA damage response [GO:0006974]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mRNA processing [GO:0006397]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA damage checkpoint [GO:2000003]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of protein deacetylation [GO:0090311]; regulation of protein stability [GO:0031647]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; DBIRD complex [GO:0044609]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	adenyl-nucleotide exchange factor activity [GO:0000774]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; unfolded protein binding [GO:0051082]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; DBIRD complex [GO:0044609]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; adenyl-nucleotide exchange factor activity [GO:0000774]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; unfolded protein binding [GO:0051082]; cell cycle [GO:0007049]; DNA damage response [GO:0006974]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mRNA processing [GO:0006397]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA damage checkpoint [GO:2000003]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of protein deacetylation [GO:0090311]; regulation of protein stability [GO:0031647]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:24962073, ECO:0000269|PubMed:25661920}. Cytoplasm {ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:24824780}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Note=Recruited to chromatin, post-UV irradiation. Sequestered to the cytoplasm in the presence of MCC. Translocated to the cytoplasm during UV-induced apoptosis. {ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:24824780}.
Q8N183	reviewed	NDUF2_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (B17.2-like) (B17.2L) (Mimitin) (Myc-induced mitochondrial protein) (MMTN) (NDUFA12-like protein)	NDUFAF2 NDUFA12L	Homo sapiens (Human)	169	FUNCTION: Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). {ECO:0000269|PubMed:16200211, ECO:0000269|PubMed:19384974, ECO:0000269|PubMed:27626371}.		mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	protein-containing complex binding [GO:0044877]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; protein-containing complex binding [GO:0044877]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15774466}.
Q8N187	reviewed	CARTF_HUMAN	Calcium-responsive transcription factor (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) (Calcium-response factor) (CaRF) (Testis development protein NYD-SP24)	CARF ALS2CR8	Homo sapiens (Human)	725	FUNCTION: Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence. {ECO:0000269|PubMed:11832226, ECO:0000269|PubMed:22174809}.		cellular response to calcium ion [GO:0071277]; regulation of transcription by RNA polymerase II [GO:0006357]	granular component [GO:0001652]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	granular component [GO:0001652]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cellular response to calcium ion [GO:0071277]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8N196	reviewed	SIX5_HUMAN	Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5)	SIX5 DMAHP	Homo sapiens (Human)	739	FUNCTION: Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). {ECO:0000250}.		lens development in camera-type eye [GO:0002088]; Leydig cell proliferation [GO:0160024]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286]	chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; lens development in camera-type eye [GO:0002088]; Leydig cell proliferation [GO:0160024]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12500905}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12500905}.
Q8N1A0	reviewed	KT222_HUMAN	Keratin-like protein KRT222 (Keratin-222) (Keratin-222 pseudogene)	KRT222 KA21 KRT222P	Homo sapiens (Human)	295				intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]	
Q8N1B3	reviewed	CCNQ_HUMAN	Cyclin-Q (CDK10-activating cyclin) (Cyclin-M) (Cyclin-related protein FAM58A)	CCNQ FAM58A	Homo sapiens (Human)	248	FUNCTION: Activating cyclin for the cyclin-associated kinase CDK10. {ECO:0000269|PubMed:18297069, ECO:0000269|PubMed:24218572}.	MISCELLANEOUS: Silencing with siRNAs phenocopies CDK10 silencing in increasing c-Raf and in conferring tamoxifen resistance to breast cancer cells.	regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of transcription by RNA polymerase II [GO:0006357]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q8N1B4	reviewed	VPS52_HUMAN	Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein)	VPS52 SACM2L	Homo sapiens (Human)	723	FUNCTION: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:18367545, ECO:0000269|PubMed:25799061}.		ectodermal cell differentiation [GO:0010668]; embryonic ectodermal digestive tract development [GO:0048611]; endocytic recycling [GO:0032456]; Golgi to vacuole transport [GO:0006896]; lysosomal transport [GO:0007041]; protein targeting [GO:0006605]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]	cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588]	syntaxin binding [GO:0019905]	cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588]; syntaxin binding [GO:0019905]; ectodermal cell differentiation [GO:0010668]; embryonic ectodermal digestive tract development [GO:0048611]; endocytic recycling [GO:0032456]; Golgi to vacuole transport [GO:0006896]; lysosomal transport [GO:0007041]; protein targeting [GO:0006605]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:18367545}; Peripheral membrane protein. Endosome membrane {ECO:0000269|PubMed:18367545}; Peripheral membrane protein. Recycling endosome {ECO:0000269|PubMed:25799061}. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061). {ECO:0000269|PubMed:25799061}.
Q8N1C3	reviewed	GBRG1_HUMAN	Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1)	GABRG1	Homo sapiens (Human)	465	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.	MISCELLANEOUS: This subunit carries the benzodiazepine binding site.	chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GABA receptor binding [GO:0050811]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]	chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; GABA receptor binding [GO:0050811]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Q8N1E6	reviewed	FXL14_HUMAN	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14)	FBXL14 FBL14	Homo sapiens (Human)	418	FUNCTION: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1. {ECO:0000269|PubMed:19955572}.		SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19955572}.
Q8N1F7	reviewed	NUP93_HUMAN	Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93)	NUP93 KIAA0095	Homo sapiens (Human)	819	FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}.		nuclear envelope organization [GO:0006998]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of SMAD protein signal transduction [GO:0060391]; protein import into nucleus [GO:0006606]; SMAD protein signal transduction [GO:0060395]	centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]	structural constituent of nuclear pore [GO:0017056]	centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; structural constituent of nuclear pore [GO:0017056]; nuclear envelope organization [GO:0006998]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of SMAD protein signal transduction [GO:0060391]; protein import into nucleus [GO:0006606]; SMAD protein signal transduction [GO:0060395]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q66HC5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q66HC5}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:9348540}. Nucleus envelope {ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. Note=Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore. {ECO:0000269|PubMed:9348540}.
Q8N1F8	reviewed	S11IP_HUMAN	Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1)	STK11IP KIAA1898 LIP1 LKB1IP STK11IP1	Homo sapiens (Human)	1088	FUNCTION: May regulate STK11/LKB1 function by controlling its subcellular localization. {ECO:0000269|PubMed:11741830}.		protein localization [GO:0008104]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]	protein kinase binding [GO:0019901]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; protein kinase binding [GO:0019901]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11741830}. Note=Some cells show granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4 in granular or punctuate structures.
Q8N1G0	reviewed	ZN687_HUMAN	Zinc finger protein 687	ZNF687 KIAA1441	Homo sapiens (Human)	1237	FUNCTION: May be involved in transcriptional regulation.			cytosol [GO:0005829]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26849110}. Nucleus {ECO:0000269|PubMed:26849110, ECO:0000269|PubMed:27732854}. Note=Predominantly nuclear (PubMed:26849110). Localizes to sites of DNA damage (PubMed:27732854). {ECO:0000269|PubMed:26849110, ECO:0000269|PubMed:27732854}.
Q8N1G1	reviewed	REXO1_HUMAN	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1)	REXO1 ELOABP1 KIAA1138 TCEB3BP1	Homo sapiens (Human)	1221	FUNCTION: Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}.			nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12943681}.
Q8N1G2	reviewed	CMTR1_HUMAN	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95)	CMTR1 FTSJD2 KIAA0082 MTR1	Homo sapiens (Human)	835	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}.		7-methylguanosine mRNA capping [GO:0006370]; cap1 mRNA methylation [GO:0097309]; mRNA methylation [GO:0080009]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483]; nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483]; nucleic acid binding [GO:0003676]; 7-methylguanosine mRNA capping [GO:0006370]; cap1 mRNA methylation [GO:0097309]; mRNA methylation [GO:0080009]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:21310715}.
Q8N1H7	reviewed	S6OS1_HUMAN	Protein SIX6OS1 (Six6 opposite strand transcript 1)	SIX6OS1 C14orf39	Homo sapiens (Human)	587	FUNCTION: Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination. Required for the appropriate processing of intermediate recombination nodules before crossover formation. {ECO:0000250|UniProtKB:Q9CTN5}.		homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705]; oogenesis [GO:0048477]; regulation of DNA-binding transcription factor activity [GO:0051090]; spermatogenesis [GO:0007283]	central element [GO:0000801]; chromosome [GO:0005694]		central element [GO:0000801]; chromosome [GO:0005694]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705]; oogenesis [GO:0048477]; regulation of DNA-binding transcription factor activity [GO:0051090]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9CTN5}. Note=Component of the central element of the synaptonemal complex. In spermatocytes, detected from zygonema to pachynema and localizes along synapsed lateral elements. Loading to the central element of the synaptonemal complex is dependent on the assembly of the tripartite synaptonemal complex structure that occurs upon synapsis between homologous chromosomes. {ECO:0000250|UniProtKB:Q9CTN5}.
Q8N1I0	reviewed	DOCK4_HUMAN	Dedicator of cytokinesis protein 4	DOCK4 KIAA0716	Homo sapiens (Human)	1966	FUNCTION: Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}.		cell chemotaxis [GO:0060326]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; small GTPase mediated signal transduction [GO:0007264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; stereocilium bundle [GO:0032421]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; stereocilium bundle [GO:0032421]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]; cell chemotaxis [GO:0060326]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12628187}. Cell projection {ECO:0000269|PubMed:20679435}. Cytoplasm, cytosol {ECO:0000305|PubMed:20679435}. Note=Colocalizes with EPHA2, RHOG and CTTN/cortactin at the tip of protrusions in migrating cells. {ECO:0000269|PubMed:20679435}.
Q8N1K5	reviewed	THMS1_HUMAN	Protein THEMIS (Thymocyte-expressed molecule involved in selection)	THEMIS C6orf190 C6orf207	Homo sapiens (Human)	641	FUNCTION: Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. {ECO:0000250|UniProtKB:Q8BGW0}.		adaptive immune response [GO:0002250]; negative T cell selection [GO:0043383]; positive T cell selection [GO:0043368]; T cell receptor signaling pathway [GO:0050852]	cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; nucleus [GO:0005634]		cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; adaptive immune response [GO:0002250]; negative T cell selection [GO:0043383]; positive T cell selection [GO:0043368]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BGW0}. Nucleus {ECO:0000250|UniProtKB:Q8BGW0}.
Q8N1L9	reviewed	BATF2_HUMAN	Basic leucine zipper transcriptional factor ATF-like 2 (B-ATF-2) (Suppressor of AP-1 regulated by IFN) (SARI)	BATF2	Homo sapiens (Human)	274	FUNCTION: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter. {ECO:0000250, ECO:0000269|PubMed:20531301}.		defense response to protozoan [GO:0042832]; integrated stress response signaling [GO:0140467]; myeloid dendritic cell differentiation [GO:0043011]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; defense response to protozoan [GO:0042832]; integrated stress response signaling [GO:0140467]; myeloid dendritic cell differentiation [GO:0043011]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Q8N1M1	reviewed	BEST3_HUMAN	Bestrophin-3 (Vitelliform macular dystrophy 2-like protein 3)	BEST3 VMD2L3	Homo sapiens (Human)	668	FUNCTION: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. {ECO:0000269|PubMed:12907679}.		negative regulation of monoatomic ion transport [GO:0043271]	chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]	chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; negative regulation of monoatomic ion transport [GO:0043271]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8N1N2	reviewed	DYNAP_HUMAN	Dynactin-associated protein (Full)	DYNAP C18orf26	Homo sapiens (Human)	210	FUNCTION: Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:20978158}.		activation of protein kinase B activity [GO:0032148]; cellular response to ergosterol [GO:1901625]; positive regulation of cell population proliferation [GO:0008284]; regulation of apoptotic process [GO:0042981]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]		Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; activation of protein kinase B activity [GO:0032148]; cellular response to ergosterol [GO:1901625]; positive regulation of cell population proliferation [GO:0008284]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:20978158}; Single-pass membrane protein {ECO:0000269|PubMed:20978158}. Cell membrane {ECO:0000269|PubMed:20978158}; Single-pass membrane protein {ECO:0000269|PubMed:20978158}. Note=Concentrated at cell-cell borders. Localizes at membranes in a microtubule-dependent manner.
Q8N1N4	reviewed	K2C78_HUMAN	Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40)	KRT78 K5B KB40	Homo sapiens (Human)	520		MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).	intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
Q8N1Q1	reviewed	CAH13_HUMAN	Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonate dehydratase XIII) (Carbonic anhydrase XIII) (CA-XIII)	CA13	Homo sapiens (Human)	262	FUNCTION: Reversible hydration of carbon dioxide.		one-carbon metabolic process [GO:0006730]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; myelin sheath [GO:0043209]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; myelin sheath [GO:0043209]; carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]; one-carbon metabolic process [GO:0006730]	
Q8N1Q8	reviewed	THEM5_HUMAN	Acyl-coenzyme A thioesterase THEM5 (Acyl-CoA thioesterase THEM5) (EC 3.1.2.2) (Acyl-coenzyme A thioesterase 15) (Thioesterase superfamily member 5)	THEM5 ACOT15	Homo sapiens (Human)	247	FUNCTION: Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (PubMed:22586271). Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271). Required for normal mitochondrial function (PubMed:22586271). {ECO:0000269|PubMed:22586271}.		cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid metabolic process [GO:0006631]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]	mitochondrial matrix [GO:0005759]	myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]	mitochondrial matrix [GO:0005759]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid metabolic process [GO:0006631]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:22586271}.
Q8N1T3	reviewed	MYO1H_HUMAN	Unconventional myosin-Ih (Myosin-1H)	MYO1H	Homo sapiens (Human)	1032	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 3]: May be due to intron retention. {ECO:0000305}.	actin filament organization [GO:0007015]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; actin filament organization [GO:0007015]; vesicle transport along actin filament [GO:0030050]	
Q8N1V2	reviewed	CFA52_HUMAN	Cilia- and flagella-associated protein 52 (WD repeat-containing protein 16) (WD40-repeat protein up-regulated in HCC)	CFAP52 WDR16 WDRPUH	Homo sapiens (Human)	620	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (PubMed:36191189). Important for proper ciliary and flagellar beating. May act in cooperation with CFAP45 and axonemal dynein subunit DNAH11 (PubMed:33139725). May play a role in cell growth and/or survival (PubMed:15967112). {ECO:0000250|UniProtKB:E1BKF9, ECO:0000269|PubMed:15967112, ECO:0000269|PubMed:33139725, ECO:0000269|PubMed:36191189}.	MISCELLANEOUS: May be a good candidate as a diagnostic marker for HCC as well as a potential molecular target for development of novel therapeutic drugs.	establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]	9+2 motile cilium [GO:0097729]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]		9+2 motile cilium [GO:0097729]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15967112}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A8ILK1}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:33139725, ECO:0000269|PubMed:36191189}. Note=Located in the proximal region of respiratory cilia. {ECO:0000269|PubMed:33139725}.
Q8N1W1	reviewed	ARG28_HUMAN	Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor)	ARHGEF28 KIAA1998 RGNEF	Homo sapiens (Human)	1705	FUNCTION: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}.		cell morphogenesis [GO:0000902]; central nervous system neuron axonogenesis [GO:0021955]; ephrin receptor signaling pathway [GO:0048013]; neurofilament cytoskeleton organization [GO:0060052]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; cell morphogenesis [GO:0000902]; central nervous system neuron axonogenesis [GO:0021955]; ephrin receptor signaling pathway [GO:0048013]; neurofilament cytoskeleton organization [GO:0060052]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with the microtubule radial and cortical systems. {ECO:0000250}.
Q8N201	reviewed	INT1_HUMAN	Integrator complex subunit 1 (Int1)	INTS1 KIAA1440 UNQ1821/PRO3434	Homo sapiens (Human)	2190	FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.		embryo implantation [GO:0007566]; inner cell mass cell proliferation [GO:0001833]; negative regulation of apoptotic process [GO:0043066]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180]; U2 snRNA 3'-end processing [GO:0034474]	integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; embryo implantation [GO:0007566]; inner cell mass cell proliferation [GO:0001833]; negative regulation of apoptotic process [GO:0043066]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180]; U2 snRNA 3'-end processing [GO:0034474]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8N205	reviewed	SYNE4_HUMAN	Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4)	SYNE4 C19orf46	Homo sapiens (Human)	404	FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). {ECO:0000250}.		establishment of epithelial cell apical/basal polarity [GO:0045198]	meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear outer membrane [GO:0005640]		meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear outer membrane [GO:0005640]; establishment of epithelial cell apical/basal polarity [GO:0045198]	SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000269|PubMed:23348741}; Single-pass type IV membrane protein {ECO:0000269|PubMed:23348741}. Note=Localization at the nucleus outer membrane requires the presence of SUN1. {ECO:0000250}.
Q8N257	reviewed	H2B3B_HUMAN	Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1)	H2BC26 H2BU1 HIST3H2BB	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.			cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q8N264	reviewed	RHG24_HUMAN	Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP)	ARHGAP24 FILGAP	Homo sapiens (Human)	748	FUNCTION: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.		angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; negative regulation of Rac protein signal transduction [GO:0035021]; negative regulation of ruffle assembly [GO:1900028]; signal transduction [GO:0007165]; wound healing, spreading of epidermal cells [GO:0035313]	adherens junction [GO:0005912]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]	GTPase activator activity [GO:0005096]	adherens junction [GO:0005912]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; GTPase activator activity [GO:0005096]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; negative regulation of Rac protein signal transduction [GO:0035021]; negative regulation of ruffle assembly [GO:1900028]; signal transduction [GO:0007165]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.
Q8N271	reviewed	PROM2_HUMAN	Prominin-2 (PROM-2) (Prominin-like protein 2) (hPROML2)	PROM2 PROML2 UNQ2521/PRO6014	Homo sapiens (Human)	834			negative regulation of caveolin-mediated endocytosis [GO:2001287]; negative regulation of pinocytosis [GO:0048550]; positive regulation of cell projection organization [GO:0031346]; positive regulation of protein phosphorylation [GO:0001934]; regulation of GTPase activity [GO:0043087]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; microspike [GO:0044393]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; prominosome [GO:0071914]	cholesterol binding [GO:0015485]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; microspike [GO:0044393]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; prominosome [GO:0071914]; cholesterol binding [GO:0015485]; negative regulation of caveolin-mediated endocytosis [GO:2001287]; negative regulation of pinocytosis [GO:0048550]; positive regulation of cell projection organization [GO:0031346]; positive regulation of protein phosphorylation [GO:0001934]; regulation of GTPase activity [GO:0043087]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with PROM1. Associates with membrane in a cholesterol-dependent manner. Localizes to the apical and basolateral membranes of epithelial cells (By similarity). {ECO:0000250}.
Q8N2A8	reviewed	PLD6_HUMAN	Mitochondrial cardiolipin hydrolase (EC 3.1.4.-) (Choline phosphatase 6) (Mitochondrial phospholipase) (MitoPLD) (Phosphatidylcholine-hydrolyzing phospholipase D6) (Phospholipase D6) (PLD6) (Protein zucchini homolog)	PLD6	Homo sapiens (Human)	252	FUNCTION: Presents phospholipase and nuclease activities, depending on the different physiological conditions (PubMed:17028579, PubMed:21397847, PubMed:28063496). Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity (PubMed:26711011). Plays a key role in mitochondrial fusion and fission via its phospholipase activity (PubMed:17028579, PubMed:24599962, PubMed:26678338). In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid (PubMed:17028579, PubMed:26711011). Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission (PubMed:24599962). Both Lipin and DAG regulate mitochondrial dynamics and membrane fusion/fission, important processes for adapting mitochondrial metabolism to changes in cell physiology. Mitochondrial fusion enables cells to cope with the increased nucleotide demand during DNA synthesis (PubMed:26678338). Mitochondrial function and dynamics are closely associated with biological processes such as cell growth, proliferation, and differentiation (PubMed:21397848). Mediator of MYC activity, promotes mitochondrial fusion and activates AMPK which in turn inhibits YAP/TAZ, thereby inducing cell growth and proliferation (PubMed:26678338). The endonuclease activity plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis (PubMed:21397847, PubMed:21397848). Implicated in spermatogenesis and sperm fertility in testicular germ cells, its single strand-specific nuclease activity is critical for the biogenesis/maturation of PIWI-interacting RNA (piRNA). MOV10L1 selectively binds to piRNA precursors and funnels them to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. Cleaves either DNA or RNA substrates with similar affinity, producing a 5' phosphate end, in this way it participates in the processing of primary piRNA transcripts. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). PA may act as signaling molecule in the recognition/transport of the precursor RNAs of primary piRNAs (PubMed:21397847). Interacts with tesmin in testes, suggesting a role in spermatogenesis via association with its interacting partner (By similarity). {ECO:0000250|UniProtKB:Q5SWZ9, ECO:0000269|PubMed:17028579, ECO:0000269|PubMed:21397847, ECO:0000269|PubMed:21397848, ECO:0000269|PubMed:24599962, ECO:0000269|PubMed:26678338, ECO:0000269|PubMed:26711011, ECO:0000269|PubMed:28063496}.		lipid catabolic process [GO:0016042]; meiotic cell cycle [GO:0051321]; mitochondrial fusion [GO:0008053]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; positive regulation of mitochondrial fusion [GO:0010636]; spermatid development [GO:0007286]	Golgi apparatus [GO:0005794]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	cardiolipin hydrolase activity [GO:0035755]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA endonuclease activity, producing 5'-phosphomonoesters [GO:0016891]	Golgi apparatus [GO:0005794]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; cardiolipin hydrolase activity [GO:0035755]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA endonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; lipid catabolic process [GO:0016042]; meiotic cell cycle [GO:0051321]; mitochondrial fusion [GO:0008053]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; positive regulation of mitochondrial fusion [GO:0010636]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:17028579}; Single-pass membrane protein {ECO:0000269|PubMed:17028579}. Golgi apparatus {ECO:0000250|UniProtKB:Q5SWZ9}. Note=Localization in the mitochondrial outer membrane is found in different cell types where phospholipase is the predominant activity, however, in pachytene spermatocytes and spermatids of mouse testes where nuclease activity is predominant, localization is restricted to the Golgi, suggesting this enzyme is localized in different subcellular compartments depending on the role (phospholipase or nuclease) it needs to play in each cell type and developmental stage. {ECO:0000305}.
Q8N2C7	reviewed	UNC80_HUMAN	Protein unc-80 homolog	UNC80 C2orf21 KIAA1843	Homo sapiens (Human)	3258	FUNCTION: Auxiliary subunit of the NALCN sodium channel complex, a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (By similarity). Activated by neuropeptides substance P, neurotensin, and extracellular Ca(2+) that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular Ca(2+) (By similarity). {ECO:0000250|UniProtKB:Q8BLN6}.		monoatomic cation homeostasis [GO:0055080]	axon [GO:0030424]; cation channel complex [GO:0034703]; plasma membrane [GO:0005886]	monoatomic cation channel activity [GO:0005261]	axon [GO:0030424]; cation channel complex [GO:0034703]; plasma membrane [GO:0005886]; monoatomic cation channel activity [GO:0005261]; monoatomic cation homeostasis [GO:0055080]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32494638}; Multi-pass membrane protein {ECO:0000255}.
Q8N2E6	reviewed	TOR2X_HUMAN	Prosalusin (Torsin family 2 member A) (Torsin-2A) [Cleaved into: Salusin-alpha; Salusin-beta]	TOR2A HEMBA1005096 PSEC0218	Homo sapiens (Human)	242	FUNCTION: Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides. {ECO:0000269|PubMed:12910263}.	MISCELLANEOUS: [Isoform 4]: Salusins -alpha and -beta peptides are derived from isoform 4.		extracellular region [GO:0005576]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; hormone activity [GO:0005179]	extracellular region [GO:0005576]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; hormone activity [GO:0005179]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12910263}.
Q8N2F6	reviewed	ARM10_HUMAN	Armadillo repeat-containing protein 10 (Splicing variant involved in hepatocarcinogenesis protein)	ARMC10 SVH PSEC0198	Homo sapiens (Human)	343	FUNCTION: May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. {ECO:0000269|PubMed:12839973, ECO:0000269|PubMed:17904127}.	MISCELLANEOUS: Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity.	negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of growth rate [GO:0040010]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	DNA binding domain binding [GO:0050692]; p53 binding [GO:0002039]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; DNA binding domain binding [GO:0050692]; p53 binding [GO:0002039]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of growth rate [GO:0040010]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12839973}; Single-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion outer membrane {ECO:0000269|PubMed:27184847}; Single-pass membrane protein {ECO:0000255}.
Q8N2G4	reviewed	LYPD1_HUMAN	Ly6/PLAUR domain-containing protein 1 (Putative HeLa tumor suppressor) (PHTS)	LYPD1 Lynx2 LYPDC1 PSEC0181 UNQ3079/PRO9917	Homo sapiens (Human)	141	FUNCTION: Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety. {ECO:0000250|UniProtKB:Q8BLC3}.		acetylcholine receptor signaling pathway [GO:0095500]; behavioral fear response [GO:0001662]; negative regulation of protein localization to plasma membrane [GO:1903077]; protein localization to plasma membrane [GO:0072659]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]	acetylcholine receptor binding [GO:0033130]; acetylcholine receptor inhibitor activity [GO:0030550]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]; acetylcholine receptor binding [GO:0033130]; acetylcholine receptor inhibitor activity [GO:0030550]; acetylcholine receptor signaling pathway [GO:0095500]; behavioral fear response [GO:0001662]; negative regulation of protein localization to plasma membrane [GO:1903077]; protein localization to plasma membrane [GO:0072659]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Q8N2G8	reviewed	GHDC_HUMAN	GH3 domain-containing protein	GHDC D11LGP1E LGP1	Homo sapiens (Human)	530				cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]	acid-amino acid ligase activity [GO:0016881]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; acid-amino acid ligase activity [GO:0016881]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99J23}. Nucleus envelope {ECO:0000250|UniProtKB:Q99J23}.
Q8N2H4	reviewed	SYS1_HUMAN	Protein SYS1 homolog	SYS1 C20orf169	Homo sapiens (Human)	156	FUNCTION: Involved in protein trafficking. May serve as a receptor for ARFRP1.		Golgi to endosome transport [GO:0006895]; Golgi to plasma membrane protein transport [GO:0043001]; protein localization to Golgi apparatus [GO:0034067]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]		cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; Golgi to endosome transport [GO:0006895]; Golgi to plasma membrane protein transport [GO:0043001]; protein localization to Golgi apparatus [GO:0034067]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15077113}; Multi-pass membrane protein {ECO:0000269|PubMed:15077113}.
Q8N2H9	reviewed	PELI3_HUMAN	E3 ubiquitin-protein ligase pellino homolog 3 (Pellino-3) (EC 2.3.2.27)	PELI3	Homo sapiens (Human)	469	FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12874243, PubMed:17675297). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12874243). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 (PubMed:12874243). Can activate AP1/JUN and ELK1 (PubMed:12874243). Acts as a regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (By similarity). Catalyzes 'Lys-63'-linked polyubiquitination of RIPK2 in parallel of XIAP (By similarity). {ECO:0000250|UniProtKB:Q8BXR6, ECO:0000269|PubMed:12874243, ECO:0000269|PubMed:17675297}.		innate immune response [GO:0045087]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein ubiquitination [GO:0016567]; regulation of Toll signaling pathway [GO:0008592]	cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; innate immune response [GO:0045087]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein ubiquitination [GO:0016567]; regulation of Toll signaling pathway [GO:0008592]	
Q8N2I9	reviewed	STK40_HUMAN	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495)	STK40 SGK495 SHIK	Homo sapiens (Human)	435	FUNCTION: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription. {ECO:0000269|PubMed:13679039}.		glycogen metabolic process [GO:0005977]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; phosphorylation [GO:0016310]; regulation of gene expression [GO:0010468]; regulation of MAPK cascade [GO:0043408]; respiratory system process [GO:0003016]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; glycogen metabolic process [GO:0005977]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; phosphorylation [GO:0016310]; regulation of gene expression [GO:0010468]; regulation of MAPK cascade [GO:0043408]; respiratory system process [GO:0003016]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:13679039}. Cytoplasm {ECO:0000269|PubMed:13679039}.
Q8N2K0	reviewed	ABD12_HUMAN	Lysophosphatidylserine lipase ABHD12 (EC 3.1.-.-) (2-arachidonoylglycerol hydrolase ABHD12) (Abhydrolase domain-containing protein 12) (hABHD12) (Monoacylglycerol lipase ABHD12) (EC 3.1.1.23) (Oxidized phosphatidylserine lipase ABHD12) (EC 3.1.-.-)	ABHD12 C20orf22	Homo sapiens (Human)	398	FUNCTION: Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30720278, PubMed:30643283). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167). {ECO:0000250|UniProtKB:Q99LR1, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24027063, ECO:0000269|PubMed:25290914, ECO:0000269|PubMed:30237167, ECO:0000269|PubMed:30420694, ECO:0000269|PubMed:30643283, ECO:0000269|PubMed:30720278}.		acylglycerol catabolic process [GO:0046464]; adult walking behavior [GO:0007628]; arachidonic acid metabolic process [GO:0019369]; glycerophospholipid catabolic process [GO:0046475]; monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]; phospholipid catabolic process [GO:0009395]; regulation of inflammatory response [GO:0050727]; response to auditory stimulus [GO:0010996]	AMPA glutamate receptor complex [GO:0032281]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	acylglycerol lipase activity [GO:0047372]; lysophospholipase activity [GO:0004622]; palmitoyl-(protein) hydrolase activity [GO:0008474]; phospholipase activity [GO:0004620]	AMPA glutamate receptor complex [GO:0032281]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; acylglycerol lipase activity [GO:0047372]; lysophospholipase activity [GO:0004622]; palmitoyl-(protein) hydrolase activity [GO:0008474]; phospholipase activity [GO:0004620]; acylglycerol catabolic process [GO:0046464]; adult walking behavior [GO:0007628]; arachidonic acid metabolic process [GO:0019369]; glycerophospholipid catabolic process [GO:0046475]; monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]; phospholipid catabolic process [GO:0009395]; regulation of inflammatory response [GO:0050727]; response to auditory stimulus [GO:0010996]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30237167}; Single-pass membrane protein {ECO:0000255}.
Q8N2K1	reviewed	UB2J2_HUMAN	Ubiquitin-conjugating enzyme E2 J2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J2) (Non-canonical ubiquitin-conjugating enzyme 2) (NCUBE-2)	UBE2J2 NCUBE2	Homo sapiens (Human)	259	FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2 (PubMed:36528027). {ECO:0000250|UniProtKB:Q6P073, ECO:0000269|PubMed:36528027}.		positive regulation of protein targeting to mitochondrion [GO:1903955]; protein K6-linked ubiquitination [GO:0085020]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein K6-linked ubiquitination [GO:0085020]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y385}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9Y385}.
Q8N2M4	reviewed	TM86A_HUMAN	Lysoplasmalogenase TMEM86A (EC 3.3.2.2) (Transmembrane protein 86A)	TMEM86A	Homo sapiens (Human)	240	FUNCTION: Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen (PubMed:36592658). Plays an important role in lysoplasmalogen metabolism in the adipocyte tissue and macrophages (PubMed:36592658). {ECO:0000269|PubMed:36592658}.		lipid metabolic process [GO:0006629]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	alkenylglycerophosphocholine hydrolase activity [GO:0047408]; hydrolase activity [GO:0016787]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; alkenylglycerophosphocholine hydrolase activity [GO:0047408]; hydrolase activity [GO:0016787]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D8N3}; Multi-pass membrane protein {ECO:0000255}.
Q8N2M8	reviewed	CLASR_HUMAN	CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2)	CLASRP SFRS16 SWAP2 UNQ2428/PRO4988	Homo sapiens (Human)	674	FUNCTION: Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8N2N9	reviewed	AN36B_HUMAN	Ankyrin repeat domain-containing protein 36B (CLL-associated antigen KW-1)	ANKRD36B	Homo sapiens (Human)	1353					identical protein binding [GO:0042802]	identical protein binding [GO:0042802]	
Q8N2Q7	reviewed	NLGN1_HUMAN	Neuroligin-1	NLGN1 KIAA1070	Homo sapiens (Human)	863	FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity). The protein is involved in nervous system development. {ECO:0000250|UniProtKB:Q99K10, ECO:0000269|PubMed:28841651}.		AMPA glutamate receptor clustering [GO:0097113]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion involved in synapse maturation [GO:0090125]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; cytoskeletal matrix organization at active zone [GO:0048789]; establishment of protein localization [GO:0045184]; excitatory synapse assembly [GO:1904861]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; maintenance of synapse structure [GO:0099558]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine morphogenesis [GO:0061002]; nervous system development [GO:0007399]; neurexin clustering involved in presynaptic membrane assembly [GO:0097115]; neuron cell-cell adhesion [GO:0007158]; neuron projection arborization [GO:0140058]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; neuronal signal transduction [GO:0023041]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of neuromuscular synaptic transmission [GO:1900075]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein localization to synapse [GO:0035418]; protein targeting [GO:0006605]; receptor localization to synapse [GO:0097120]; regulation of AMPA receptor activity [GO:2000311]; regulation of neuron differentiation [GO:0045664]; regulation of NMDA receptor activity [GO:2000310]; rhythmic process [GO:0048511]; synapse assembly [GO:0007416]; synapse maturation [GO:0060074]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle targeting [GO:0016080]; terminal button organization [GO:0072553]	asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; filopodium tip [GO:0032433]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; inhibitory synapse [GO:0060077]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron to neuron synapse [GO:0098984]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; presynapse [GO:0098793]; protein complex involved in cell-cell adhesion [GO:0098635]; receptor complex [GO:0043235]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	amyloid-beta binding [GO:0001540]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; neurexin family protein binding [GO:0042043]; PDZ domain binding [GO:0030165]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]	asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; filopodium tip [GO:0032433]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; inhibitory synapse [GO:0060077]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron to neuron synapse [GO:0098984]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; presynapse [GO:0098793]; protein complex involved in cell-cell adhesion [GO:0098635]; receptor complex [GO:0043235]; synapse [GO:0045202]; synaptic cleft [GO:0043083]; amyloid-beta binding [GO:0001540]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; neurexin family protein binding [GO:0042043]; PDZ domain binding [GO:0030165]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]; AMPA glutamate receptor clustering [GO:0097113]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion involved in synapse maturation [GO:0090125]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; cytoskeletal matrix organization at active zone [GO:0048789]; establishment of protein localization [GO:0045184]; excitatory synapse assembly [GO:1904861]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; maintenance of synapse structure [GO:0099558]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine morphogenesis [GO:0061002]; nervous system development [GO:0007399]; neurexin clustering involved in presynaptic membrane assembly [GO:0097115]; neuron cell-cell adhesion [GO:0007158]; neuron projection arborization [GO:0140058]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; neuronal signal transduction [GO:0023041]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of neuromuscular synaptic transmission [GO:1900075]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein localization to synapse [GO:0035418]; protein targeting [GO:0006605]; receptor localization to synapse [GO:0097120]; regulation of AMPA receptor activity [GO:2000311]; regulation of neuron differentiation [GO:0045664]; regulation of NMDA receptor activity [GO:2000310]; rhythmic process [GO:0048511]; synapse assembly [GO:0007416]; synapse maturation [GO:0060074]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle targeting [GO:0016080]; terminal button organization [GO:0072553]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28841651}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62765}. Postsynaptic density {ECO:0000250|UniProtKB:Q62765}. Synaptic cleft {ECO:0000250|UniProtKB:Q62765}. Synaptic cell membrane {ECO:0000250|UniProtKB:Q62765}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1. {ECO:0000250|UniProtKB:Q62765}.
Q8N2R0	reviewed	OSR2_HUMAN	Protein odd-skipped-related 2	OSR2	Homo sapiens (Human)	312	FUNCTION: May be involved in the development of the mandibular molar tooth germ at the bud stage. {ECO:0000250|UniProtKB:Q91ZD1}.		bone morphogenesis [GO:0060349]; cell differentiation [GO:0030154]; chondrocyte differentiation [GO:0002062]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal joint development [GO:0072498]; embryonic skeletal joint morphogenesis [GO:0060272]; embryonic skeletal limb joint morphogenesis [GO:0036023]; embryonic skeletal system morphogenesis [GO:0048704]; eyelid development in camera-type eye [GO:0061029]; head development [GO:0060322]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; middle ear morphogenesis [GO:0042474]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; osteoblast proliferation [GO:0033687]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; stem cell proliferation [GO:0072089]; urogenital system development [GO:0001655]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; bone morphogenesis [GO:0060349]; cell differentiation [GO:0030154]; chondrocyte differentiation [GO:0002062]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal joint development [GO:0072498]; embryonic skeletal joint morphogenesis [GO:0060272]; embryonic skeletal limb joint morphogenesis [GO:0036023]; embryonic skeletal system morphogenesis [GO:0048704]; eyelid development in camera-type eye [GO:0061029]; head development [GO:0060322]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; middle ear morphogenesis [GO:0042474]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; osteoblast proliferation [GO:0033687]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; stem cell proliferation [GO:0072089]; urogenital system development [GO:0001655]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N2S1	reviewed	LTBP4_HUMAN	Latent-transforming growth factor beta-binding protein 4 (LTBP-4)	LTBP4	Homo sapiens (Human)	1624	FUNCTION: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. {ECO:0000250|UniProtKB:Q14766}.		elastic fiber assembly [GO:0048251]; hormone secretion [GO:0046879]; protein folding [GO:0006457]; regulation of cell growth [GO:0001558]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transforming growth factor beta receptor signaling pathway [GO:0007179]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527]	calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; integrin binding [GO:0005178]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; integrin binding [GO:0005178]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; elastic fiber assembly [GO:0048251]; hormone secretion [GO:0046879]; protein folding [GO:0006457]; regulation of cell growth [GO:0001558]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:16157329, ECO:0000269|PubMed:9660815}.
Q8N2U9	reviewed	S66A2_HUMAN	Solute carrier family 66 member 2 (PQ-loop repeat-containing protein 1)	SLC66A2 PQLC1	Homo sapiens (Human)	271			phospholipid translocation [GO:0045332]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; endosome [GO:0005768]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]		cytosol [GO:0005829]; endosome [GO:0005768]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; phospholipid translocation [GO:0045332]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N2W9	reviewed	PIAS4_HUMAN	E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)	PIAS4 PIASG	Homo sapiens (Human)	510	FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:12511558, PubMed:12631292, PubMed:12727872, PubMed:15831457, PubMed:15976810, PubMed:22508508, PubMed:32832608). Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168 (PubMed:12511558, PubMed:12631292, PubMed:12727872, PubMed:15831457, PubMed:15976810, PubMed:22508508). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway (PubMed:11388671). Involved in gene silencing (PubMed:11248056). In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations (PubMed:12727872, PubMed:15831457). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs) (By similarity). Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:32832608). Mediates sumoylation of PARP1 in response to PARP1 trapping to chromatin (PubMed:35013556). {ECO:0000250|UniProtKB:Q9JM05, ECO:0000269|PubMed:11248056, ECO:0000269|PubMed:11388671, ECO:0000269|PubMed:12511558, ECO:0000269|PubMed:12631292, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:35013556}.		central nervous system development [GO:0007417]; double-strand break repair [GO:0006302]; hair follicle development [GO:0001942]; limb epidermis development [GO:0060887]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of keratinocyte apoptotic process [GO:1902174]; positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925]; regulation of transcription by RNA polymerase II [GO:0006357]; vitamin D metabolic process [GO:0042359]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; transferase complex [GO:1990234]	DNA binding [GO:0003677]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; transferase complex [GO:1990234]; DNA binding [GO:0003677]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; central nervous system development [GO:0007417]; double-strand break repair [GO:0006302]; hair follicle development [GO:0001942]; limb epidermis development [GO:0060887]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of keratinocyte apoptotic process [GO:1902174]; positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925]; regulation of transcription by RNA polymerase II [GO:0006357]; vitamin D metabolic process [GO:0042359]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000269|PubMed:11248056, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457}. Note=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies. {ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457}.
Q8N2Y8	reviewed	RUSC2_HUMAN	AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2)	RUSC2 KIAA0375	Homo sapiens (Human)	1516	FUNCTION: Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}.			cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	small GTPase binding [GO:0031267]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; small GTPase binding [GO:0031267]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15796781}. Note=Cytosolic punctate distribution. Also observed in the perinuclear region. {ECO:0000269|PubMed:15796781}.
Q8N2Z9	reviewed	CENPS_HUMAN	Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain-containing protein 1) (FANCM-associated histone fold protein 1) (FANCM-interacting histone fold protein 1) (Fanconi anemia-associated polypeptide of 16 kDa)	CENPS APITD1 FAAP16 MHF1	Homo sapiens (Human)	138	FUNCTION: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM (PubMed:20347428, PubMed:20347429). In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428). In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:22304917). DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347428, PubMed:20347429). {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:22304917}.		cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; interstrand cross-link repair [GO:0036297]; positive regulation of protein ubiquitination [GO:0031398]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]	chromatin [GO:0000785]; cytosol [GO:0005829]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]	chromatin [GO:0000785]; cytosol [GO:0005829]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; interstrand cross-link repair [GO:0036297]; positive regulation of protein ubiquitination [GO:0031398]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:24522885}. Chromosome, centromere {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19620631}. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPS is more stably bound at the kinetochore than CENPX (PubMed:19620631, PubMed:24522885). During S phase, rapidly recruited to DNA interstrand cross-links that block replication (PubMed:20347428). Recruited to DNA damage sites about 20 minutes following UV irradiation, reaching a plateau after approximately 40 minutes (PubMed:24522885). {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:24522885}.
Q8N300	reviewed	SVBP_HUMAN	Small vasohibin-binding protein (Coiled coil domain-containing protein 23)	SVBP CCDC23	Homo sapiens (Human)	66	FUNCTION: Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869, PubMed:31270470, PubMed:31235911, PubMed:31324789, PubMed:31171830, PubMed:31235910). This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017, PubMed:30607023). Plays a role in axon and excitatory synapse formation (PubMed:31235911). {ECO:0000269|PubMed:20736312, ECO:0000269|PubMed:27879017, ECO:0000269|PubMed:29146869, ECO:0000269|PubMed:30607023, ECO:0000269|PubMed:31171830, ECO:0000269|PubMed:31235910, ECO:0000269|PubMed:31235911, ECO:0000269|PubMed:31270470, ECO:0000269|PubMed:31324789}.		axon development [GO:0061564]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein ubiquitination [GO:0031397]; protein secretion [GO:0009306]; proteolysis [GO:0006508]; regulation of metallopeptidase activity [GO:1905048]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]	microtubule binding [GO:0008017]; peptidase activator activity [GO:0016504]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; microtubule binding [GO:0008017]; peptidase activator activity [GO:0016504]; axon development [GO:0061564]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein ubiquitination [GO:0031397]; protein secretion [GO:0009306]; proteolysis [GO:0006508]; regulation of metallopeptidase activity [GO:1905048]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99LQ4}. Secreted {ECO:0000250|UniProtKB:Q99LQ4}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:31235911}. Note=Detected both intracellularly and extracellularly (By similarity). Within cells, localizes mainly to the apical part of the cell (By similarity). {ECO:0000250|UniProtKB:Q99LQ4}.
Q8N302	reviewed	AGGF1_HUMAN	Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein)	AGGF1 GPATC7 GPATCH7 VG5Q	Homo sapiens (Human)	714	FUNCTION: Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}.		angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]	nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]; nucleic acid binding [GO:0003676]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14961121}. Secreted {ECO:0000269|PubMed:14961121}. Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted.
Q8N307	reviewed	MUC20_HUMAN	Mucin-20 (MUC-20)	MUC20 KIAA1359 UNQ2782/PRO7170	Homo sapiens (Human)	709	FUNCTION: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. {ECO:0000269|PubMed:15314156}.		hepatocyte growth factor receptor signaling pathway [GO:0048012]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; hepatocyte growth factor receptor signaling pathway [GO:0048012]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:14565953}. Basolateral cell membrane {ECO:0000269|PubMed:14565953}. Cell projection, microvillus membrane {ECO:0000269|PubMed:14565953}.
Q8N335	reviewed	GPD1L_HUMAN	Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1-L) (EC 1.1.1.8)	GPD1L KIAA0089	Homo sapiens (Human)	351	FUNCTION: Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. {ECO:0000269|PubMed:19666841, ECO:0000269|PubMed:19745168}.		carbohydrate metabolic process [GO:0005975]; glycerol-3-phosphate catabolic process [GO:0046168]; NAD metabolic process [GO:0019674]; NADH metabolic process [GO:0006734]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein kinase C signaling [GO:0090038]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of sodium ion transport [GO:0010765]; regulation of heart rate [GO:0002027]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; ventricular cardiac muscle cell action potential [GO:0086005]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycerol-3-phosphate dehydrogenase complex [GO:0009331]; plasma membrane [GO:0005886]	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952]; NAD binding [GO:0051287]; protein homodimerization activity [GO:0042803]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycerol-3-phosphate dehydrogenase complex [GO:0009331]; plasma membrane [GO:0005886]; glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952]; NAD binding [GO:0051287]; protein homodimerization activity [GO:0042803]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; carbohydrate metabolic process [GO:0005975]; glycerol-3-phosphate catabolic process [GO:0046168]; NAD metabolic process [GO:0019674]; NADH metabolic process [GO:0006734]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein kinase C signaling [GO:0090038]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of sodium ion transport [GO:0010765]; regulation of heart rate [GO:0002027]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17967977}. Note=Localized to the region of the plasma membrane.
Q8N339	reviewed	MT1M_HUMAN	Metallothionein-1M (MT-1M) (Metallothionein-IM) (MT-IM)	MT1M MT1K	Homo sapiens (Human)	61	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.		cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	
Q8N344	reviewed	MIER2_HUMAN	Mesoderm induction early response protein 2 (Mi-er2)	MIER2 KIAA1193	Homo sapiens (Human)	545	FUNCTION: Transcriptional repressor. {ECO:0000250}.		chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.
Q8N350	reviewed	CBARP_HUMAN	Voltage-dependent calcium channel beta subunit-associated regulatory protein	CBARP C19orf26	Homo sapiens (Human)	705	FUNCTION: Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}.		negative regulation of calcium ion transmembrane transport [GO:1903170]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of voltage-gated calcium channel activity [GO:1901386]	growth cone [GO:0030426]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672]	transmembrane transporter binding [GO:0044325]	growth cone [GO:0030426]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter binding [GO:0044325]; negative regulation of calcium ion transmembrane transport [GO:1903170]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of voltage-gated calcium channel activity [GO:1901386]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q66L44}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q66L44}. Cell membrane {ECO:0000250|UniProtKB:Q66L44}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q66L44}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q66L44}.
Q8N357	reviewed	S35F6_HUMAN	Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog)	SLC35F6 C2orf18 UNQ3047/PRO9863	Homo sapiens (Human)	371	FUNCTION: Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter. {ECO:0000269|PubMed:19154410}.		negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation of cell population proliferation [GO:0008284]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	transmembrane transporter activity [GO:0022857]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; transmembrane transporter activity [GO:0022857]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Mitochondrion. Lysosome membrane; Multi-pass membrane protein.
Q8N370	reviewed	LAT4_HUMAN	Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2)	SLC43A2 LAT4 PP7664	Homo sapiens (Human)	569	FUNCTION: Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine (PubMed:30379325, PubMed:15659399). The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent (PubMed:15659399). {ECO:0000269|PubMed:15659399, ECO:0000269|PubMed:30379325}.		amino acid transport [GO:0006865]; isoleucine transport [GO:0015818]; leucine transport [GO:0015820]; methionine transport [GO:0015821]; negative regulation of amino acid transport [GO:0051956]; negative regulation of leucine import [GO:0060358]; neutral amino acid transport [GO:0015804]; phenylalanine transport [GO:0015823]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; L-amino acid transmembrane transporter activity [GO:0015179]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-leucine transmembrane transporter activity [GO:0015190]; L-methionine transmembrane transporter activity [GO:0015191]; L-phenylalanine transmembrane transporter activity [GO:0015192]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; L-amino acid transmembrane transporter activity [GO:0015179]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-leucine transmembrane transporter activity [GO:0015190]; L-methionine transmembrane transporter activity [GO:0015191]; L-phenylalanine transmembrane transporter activity [GO:0015192]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; amino acid transport [GO:0006865]; isoleucine transport [GO:0015818]; leucine transport [GO:0015820]; methionine transport [GO:0015821]; negative regulation of amino acid transport [GO:0051956]; negative regulation of leucine import [GO:0060358]; neutral amino acid transport [GO:0015804]; phenylalanine transport [GO:0015823]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30379325}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8CGA3}. Note=Located at the basolateral membrane in the small intestine enterocytes, kidney proximal tubule, thick ascending limb and, to a minor extent, of distal convoluted tubule epithelial cells. {ECO:0000250|UniProtKB:Q8CGA3}.
Q8N371	reviewed	KDM8_HUMAN	Bifunctional peptidase and arginyl-hydroxylase JMJD5 (EC 1.14.11.73) (EC 3.4.-.-) (JmjC domain-containing protein 5) (Jumonji C domain-containing protein 5) (L-arginine (3R)-hydroxylase KDM8)	KDM8 JMJD5	Homo sapiens (Human)	416	FUNCTION: Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (PubMed:28847961, PubMed:29459673, PubMed:28982940, PubMed:29563586). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961, PubMed:29459673, PubMed:28982940). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961, PubMed:29459673). Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage (PubMed:28982940). Additionnally, acts as Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established (PubMed:29563586). Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition (PubMed:24740926). Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation (PubMed:20457893). Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (PubMed:28455245). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a catalytically-independent manner (PubMed:30500822). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822). {ECO:0000250|UniProtKB:Q9CXT6, ECO:0000269|PubMed:20457893, ECO:0000269|PubMed:24740926, ECO:0000269|PubMed:24981860, ECO:0000269|PubMed:28455245, ECO:0000269|PubMed:28847961, ECO:0000269|PubMed:28982940, ECO:0000269|PubMed:29459673, ECO:0000269|PubMed:29563586, ECO:0000269|PubMed:30500822}.		circadian regulation of gene expression [GO:0032922]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; protein destabilization [GO:0031648]; proteolysis [GO:0006508]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	aminopeptidase activity [GO:0004177]; chromatin binding [GO:0003682]; endopeptidase activity [GO:0004175]; histone H3K36 demethylase activity [GO:0051864]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; peptidyl-arginine 3-dioxygenase activity [GO:0106157]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; aminopeptidase activity [GO:0004177]; chromatin binding [GO:0003682]; endopeptidase activity [GO:0004175]; histone H3K36 demethylase activity [GO:0051864]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; peptidyl-arginine 3-dioxygenase activity [GO:0106157]; circadian regulation of gene expression [GO:0032922]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; protein destabilization [GO:0031648]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20457893, ECO:0000269|PubMed:28982940}. Chromosome {ECO:0000269|PubMed:24981860}. Note=Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3). {ECO:0000269|PubMed:24981860}.
Q8N386	reviewed	LRC25_HUMAN	Leucine-rich repeat-containing protein 25 (Monocyte and plasmacytoid-activated protein)	LRRC25 MAPA UNQ6169/PRO20174	Homo sapiens (Human)	305	FUNCTION: Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy (PubMed:29288164). Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. {ECO:0000269|PubMed:12384430, ECO:0000269|PubMed:29044191, ECO:0000269|PubMed:29288164}.			cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]		cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:29044191}.
Q8N387	reviewed	MUC15_HUMAN	Mucin-15 (MUC-15)	MUC15 UNQ750/PRO1481	Homo sapiens (Human)	334	FUNCTION: May play a role in the cell adhesion to the extracellular matrix.			extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q8N392	reviewed	RHG18_HUMAN	Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18)	ARHGAP18	Homo sapiens (Human)	663	FUNCTION: Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}.		regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21865595}.
Q8N393	reviewed	ZN786_HUMAN	Zinc finger protein 786	ZNF786	Homo sapiens (Human)	782	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N394	reviewed	TMTC2_HUMAN	Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane and TPR repeat-containing protein 2)	TMTC2	Homo sapiens (Human)	836	FUNCTION: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. {ECO:0000269|PubMed:28973932}.		calcium ion homeostasis [GO:0055074]; protein O-linked mannosylation [GO:0035269]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]; calcium ion homeostasis [GO:0055074]; protein O-linked mannosylation [GO:0035269]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000305}.
Q8N3A8	reviewed	PARP8_HUMAN	Protein mono-ADP-ribosyltransferase PARP8 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 16) (ARTD16) (Poly [ADP-ribose] polymerase 8) (PARP-8)	PARP8	Homo sapiens (Human)	854	FUNCTION: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}.		endoplasmic reticulum unfolded protein response [GO:0030968]; protein auto-ADP-ribosylation [GO:0070213]	endoplasmic reticulum tubular network [GO:0071782]; nuclear envelope [GO:0005635]	kinase binding [GO:0019900]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; protein serine/threonine kinase activator activity [GO:0043539]	endoplasmic reticulum tubular network [GO:0071782]; nuclear envelope [GO:0005635]; kinase binding [GO:0019900]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; protein serine/threonine kinase activator activity [GO:0043539]; endoplasmic reticulum unfolded protein response [GO:0030968]; protein auto-ADP-ribosylation [GO:0070213]	
Q8N3C0	reviewed	ASCC3_HUMAN	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200)	ASCC3 HELIC1 RQT2	Homo sapiens (Human)	2202	FUNCTION: ATPase involved both in DNA repair and rescue of stalled ribosomes (PubMed:22055184, PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184, ECO:0000269|PubMed:28757607, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}.		cell population proliferation [GO:0008283]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	activating signal cointegrator 1 complex [GO:0099053]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; DNA repair complex [GO:1990391]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]	activating signal cointegrator 1 complex [GO:0099053]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; DNA repair complex [GO:1990391]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; cell population proliferation [GO:0008283]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457}. Nucleus speckle {ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:29997253}. Cytoplasm, cytosol {ECO:0000269|PubMed:28757607}. Note=Colocalizes with ALKBH3 and ASCC2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. {ECO:0000269|PubMed:29144457}.
Q8N3C7	reviewed	CLIP4_HUMAN	CAP-Gly domain-containing linker protein 4 (Restin-like protein 2)	CLIP4 RSNL2	Homo sapiens (Human)	705			cytoplasmic microtubule organization [GO:0031122]	cell cortex [GO:0005938]; intracellular membrane-bounded organelle [GO:0043231]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]	microtubule plus-end binding [GO:0051010]	cell cortex [GO:0005938]; intracellular membrane-bounded organelle [GO:0043231]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]; microtubule plus-end binding [GO:0051010]; cytoplasmic microtubule organization [GO:0031122]	
Q8N3E9	reviewed	PLCD3_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)	PLCD3 KIAA1964	Homo sapiens (Human)	789	FUNCTION: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). {ECO:0000250|UniProtKB:Q8K2J0, ECO:0000269|PubMed:10336610}.		angiogenesis [GO:0001525]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; lipid catabolic process [GO:0016042]; regulation of cell population proliferation [GO:0042127]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; phosphatidylinositol phospholipase C activity [GO:0004435]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; phosphatidylinositol phospholipase C activity [GO:0004435]; angiogenesis [GO:0001525]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; lipid catabolic process [GO:0016042]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow {ECO:0000269|PubMed:17041247}. Note=Localizes at the cleavage furrow during cytokinesis. {ECO:0000269|PubMed:17041247}.
Q8N3F0	reviewed	MTURN_HUMAN	Maturin (Maturin neural progenitor differentiation regulator protein homolog) (Protein Ells1)	MTURN C7orf41	Homo sapiens (Human)	131	FUNCTION: Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser-536' (PubMed:24681962). May be involved in early neuronal development (By similarity). {ECO:0000250|UniProtKB:Q7ZX36, ECO:0000269|PubMed:24681962}.		negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of signaling [GO:0023051]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of signaling [GO:0023051]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24681962}.
Q8N3F8	reviewed	MILK1_HUMAN	MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13)	MICALL1 KIAA1668 MIRAB13	Homo sapiens (Human)	863	FUNCTION: Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth. {ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323}.		endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; neuron projection development [GO:0031175]; plasma membrane tubulation [GO:0097320]; protein localization to endosome [GO:0036010]; protein targeting to membrane [GO:0006612]; receptor-mediated endocytosis [GO:0006898]; slow endocytic recycling [GO:0032458]	cytoplasmic side of endosome membrane [GO:0010009]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; recycling endosome membrane [GO:0055038]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidic acid binding [GO:0070300]; small GTPase binding [GO:0031267]	cytoplasmic side of endosome membrane [GO:0010009]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; recycling endosome membrane [GO:0055038]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidic acid binding [GO:0070300]; small GTPase binding [GO:0031267]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; neuron projection development [GO:0031175]; plasma membrane tubulation [GO:0097320]; protein localization to endosome [GO:0036010]; protein targeting to membrane [GO:0006612]; receptor-mediated endocytosis [GO:0006898]; slow endocytic recycling [GO:0032458]	SUBCELLULAR LOCATION: Recycling endosome membrane; Peripheral membrane protein. Late endosome membrane. Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6.
Q8N3G9	reviewed	TM130_HUMAN	Transmembrane protein 130	TMEM130 UNQ719/PRO1383	Homo sapiens (Human)	435				Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]		Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11256614}; Single-pass type I membrane protein {ECO:0000269|PubMed:11256614}.
Q8N3I7	reviewed	BBS5_HUMAN	Bardet-Biedl syndrome 5 protein	BBS5	Homo sapiens (Human)	341	FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.	MISCELLANEOUS: BBS5 may interact genetically with BBS1.	cilium assembly [GO:0060271]; heart looping [GO:0001947]; intracellular transport [GO:0046907]; melanosome transport [GO:0032402]; motile cilium assembly [GO:0044458]; protein transport [GO:0015031]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	axoneme [GO:0005930]; BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]	phosphatidylinositol-3-phosphate binding [GO:0032266]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	axoneme [GO:0005930]; BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; phosphatidylinositol-3-phosphate binding [GO:0032266]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; cilium assembly [GO:0060271]; heart looping [GO:0001947]; intracellular transport [GO:0046907]; melanosome transport [GO:0032402]; motile cilium assembly [GO:0044458]; protein transport [GO:0015031]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to basal bodies. {ECO:0000250}.
Q8N3J2	reviewed	METL4_HUMAN	N(6)-adenine-specific methyltransferase METTL4 (Methyltransferase-like protein 4) (N(6)-adenine-specific DNA methyltransferase METTL4) (EC 2.1.1.72) (snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4) (EC 2.1.1.-)	METTL4	Homo sapiens (Human)	472	FUNCTION: N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA (PubMed:31913360, PubMed:32183942). Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation (PubMed:31913360). Internal m6A(m) methylation of snRNAs regulates RNA splicing (PubMed:31913360). Also able to act as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:32183942). The existence of N(6)-methyladenosine (m6A) on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6)-adenine-specific DNA methyltransferase activity of METTL4 in vivo (PubMed:32203414). Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA) copy number by mediating mtDNA N(6)-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending (PubMed:32183942). N(6)-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity). {ECO:0000250|UniProtKB:Q3U034, ECO:0000269|PubMed:31913360, ECO:0000269|PubMed:32183942, ECO:0000269|PubMed:32203414}.		chromatin organization [GO:0006325]; DNA methylation on adenine [GO:0032775]; mRNA methylation [GO:0080009]; regulation of chromatin organization [GO:1902275]; regulation of mitochondrial DNA replication [GO:0090296]; regulation of mitochondrial transcription [GO:1903108]; regulation of RNA splicing [GO:0043484]; snRNA (adenine-N6)-methylation [GO:0120049]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	nucleic acid binding [GO:0003676]; RNA methyltransferase activity [GO:0008173]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007]; U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity [GO:0106347]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; nucleic acid binding [GO:0003676]; RNA methyltransferase activity [GO:0008173]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007]; U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity [GO:0106347]; chromatin organization [GO:0006325]; DNA methylation on adenine [GO:0032775]; mRNA methylation [GO:0080009]; regulation of chromatin organization [GO:1902275]; regulation of mitochondrial DNA replication [GO:0090296]; regulation of mitochondrial transcription [GO:1903108]; regulation of RNA splicing [GO:0043484]; snRNA (adenine-N6)-methylation [GO:0120049]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31913360, ECO:0000269|PubMed:32183942}. Cytoplasm, cytosol {ECO:0000269|PubMed:32183942}. Mitochondrion matrix {ECO:0000269|PubMed:32183942}.
Q8N3J3	reviewed	HROB_HUMAN	Homologous recombination OB-fold protein	HROB C17orf53	Homo sapiens (Human)	647	FUNCTION: DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}.		DNA damage response [GO:0006974]; DNA synthesis involved in DNA repair [GO:0000731]; female gamete generation [GO:0007292]; interstrand cross-link repair [GO:0036297]; male gamete generation [GO:0048232]; recombinational repair [GO:0000725]	nucleus [GO:0005634]; site of DNA damage [GO:0090734]	single-stranded DNA binding [GO:0003697]	nucleus [GO:0005634]; site of DNA damage [GO:0090734]; single-stranded DNA binding [GO:0003697]; DNA damage response [GO:0006974]; DNA synthesis involved in DNA repair [GO:0000731]; female gamete generation [GO:0007292]; interstrand cross-link repair [GO:0036297]; male gamete generation [GO:0048232]; recombinational repair [GO:0000725]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31467087}. Chromosome {ECO:0000269|PubMed:31467087}. Note=Localized to the sites of DNA damage. {ECO:0000269|PubMed:31467087}.
Q8N3J5	reviewed	PPM1K_HUMAN	Protein phosphatase 1K, mitochondrial (EC 3.1.3.16) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C isoform kappa) (PP2C-kappa)	PPM1K PP2CM	Homo sapiens (Human)	372	FUNCTION: Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. {ECO:0000269|PubMed:17374715}.			mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:17336929, ECO:0000269|PubMed:17374715}.
Q8N3J6	reviewed	CADM2_HUMAN	Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2)	CADM2 IGSF4D NECL3	Homo sapiens (Human)	435	FUNCTION: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. {ECO:0000269|PubMed:17967169}.		homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	axon [GO:0030424]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; synapse [GO:0045202]		axon [GO:0030424]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; synapse [GO:0045202]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17967169}; Single-pass type I membrane protein {ECO:0000269|PubMed:17967169}. Synapse {ECO:0000269|PubMed:17967169}. Cell projection, axon {ECO:0000269|PubMed:17967169}. Note=Found in the axoplasm of myelinated axons.
Q8N3K9	reviewed	CMYA5_HUMAN	Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76)	CMYA5 C5orf10 DTNBP2 SPRYD2 TRIM76	Homo sapiens (Human)	4069	FUNCTION: May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; M band [GO:0031430]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; M band [GO:0031430]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A0A286XF80}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:A0A286XF80}. Cytoplasm {ECO:0000250|UniProtKB:Q70KF4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:A0A286XF80}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:20634290}. Note=Found predominantly at the periphery of the nucleus but also throughout the cell. Localized in lysosomes (By similarity). In skeletal muscles, localizes along myofiber periphery, at costameres (By similarity). Predominantly flanks Z-disks (By similarity). Occasionally present at the M-band level. Colocalized with RYR2 in the sarcoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:A0A286XF80}.
Q8N3L3	reviewed	TXLNB_HUMAN	Beta-taxilin (Muscle-derived protein 77) (hMDP77)	TXLNB C6orf198 MDP77	Homo sapiens (Human)	684	FUNCTION: Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic. {ECO:0000250}.			cytoplasm [GO:0005737]	syntaxin binding [GO:0019905]	cytoplasm [GO:0005737]; syntaxin binding [GO:0019905]	
Q8N3P4	reviewed	VPS8_HUMAN	Vacuolar protein sorting-associated protein 8 homolog	VPS8 KIAA0804	Homo sapiens (Human)	1428	FUNCTION: Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290). {ECO:0000269|PubMed:25266290, ECO:0000305|PubMed:25266290}.		endosomal vesicle fusion [GO:0034058]; protein targeting to vacuole [GO:0006623]; regulation of SNARE complex assembly [GO:0035542]	CORVET complex [GO:0033263]; early endosome [GO:0005769]; HOPS complex [GO:0030897]; late endosome [GO:0005770]	metal ion binding [GO:0046872]	CORVET complex [GO:0033263]; early endosome [GO:0005769]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; metal ion binding [GO:0046872]; endosomal vesicle fusion [GO:0034058]; protein targeting to vacuole [GO:0006623]; regulation of SNARE complex assembly [GO:0035542]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:25266290}.
Q8N3R9	reviewed	PALS1_HUMAN	Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)	PALS1 MPP5	Homo sapiens (Human)	675	FUNCTION: Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:25385611, ECO:0000269|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269|PubMed:20861307, ECO:0000303|PubMed:32891874}.		central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; gene expression [GO:0010467]; generation of neurons [GO:0048699]; morphogenesis of an epithelial sheet [GO:0002011]; myelin assembly [GO:0032288]; peripheral nervous system myelin maintenance [GO:0032287]; protein localization to myelin sheath abaxonal region [GO:0035750]; protein localization to plasma membrane [GO:0072659]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lateral loop [GO:0043219]; myelin sheath adaxonal region [GO:0035749]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Schmidt-Lanterman incisure [GO:0043220]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lateral loop [GO:0043219]; myelin sheath adaxonal region [GO:0035749]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Schmidt-Lanterman incisure [GO:0043220]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; gene expression [GO:0010467]; generation of neurons [GO:0048699]; morphogenesis of an epithelial sheet [GO:0002011]; myelin assembly [GO:0032288]; peripheral nervous system myelin maintenance [GO:0032287]; protein localization to myelin sheath abaxonal region [GO:0035750]; protein localization to plasma membrane [GO:0072659]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:21479189}. Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junction, tight junction {ECO:0000269|PubMed:20861307}. Cell junction, adherens junction {ECO:0000269|PubMed:16519681}. Cell projection, axon {ECO:0000250|UniProtKB:Q9JLB2}. Perikaryon {ECO:0000250|UniProtKB:Q9JLB2}. Apical cell membrane {ECO:0000269|PubMed:15914641, ECO:0000269|PubMed:16519681, ECO:0000269|PubMed:25385611}. Note=Localized to the tight junctions of epithelial cells (By similarity). Localized to the Golgi apparatus in T lymphocytes (PubMed:21479189). Localized to a subset of intracellular vesicles (By similarity). Localized to the Purkinje cell body and axon (By similarity). Localized to intercellular junctions in vascular endothelial cells (PubMed:27466317). Localized to Schmidt-Lanterman incisures, the adaxonal domain, and the inner part of paranodal loops in myelinating Schwann cells of the sciatic nerve (By similarity). Localized to apical membrane domains of the outer limiting membrane (OLM) junctions in the retina (By similarity). Colocalizes with CRB1 at the OLM, apical to the adherens junction (PubMed:15914641). Colocalizes with MPP1 in the retina at the OLM (PubMed:17584769). Colocalizes with MPP3 to the subapical region of adherens junctions in the retina OLM (PubMed:16519681). {ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:15914641, ECO:0000269|PubMed:16519681, ECO:0000269|PubMed:17584769, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:27466317}.; SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:20861307}. Golgi apparatus {ECO:0000269|PubMed:20861307}. Note=(Microbial infection) Following infection by human SARS coronavirus, partially localized at the site of viral replication; the endoplasmic reticulum-Golgi intermediate compartment, reducing its levels at cell-cell contacts which results in delayed formation of tight junctions and affects establishment of cell polarity. {ECO:0000269|PubMed:20861307}.
Q8N3T1	reviewed	GLT15_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 15 (EC 2.4.1.41) (Polypeptide GalNAc transferase-like protein 2) (GalNAc-T-like protein 2) (pp-GaNTase-like protein 2) (Polypeptide N-acetylgalactosaminyltransferase-like protein 2) (Protein-UDP acetylgalactosaminyltransferase-like protein 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2)	GALNT15 GALNTL2 UNQ770/PRO1564	Homo sapiens (Human)	639	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate. {ECO:0000269|PubMed:15147861}.		O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q8N3U4	reviewed	STAG2_HUMAN	Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2)	STAG2 SA2	Homo sapiens (Human)	1231	FUNCTION: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}.		cell division [GO:0051301]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic spindle assembly [GO:0090307]; sister chromatid cohesion [GO:0007062]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; cell division [GO:0051301]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic spindle assembly [GO:0090307]; sister chromatid cohesion [GO:0007062]	SUBCELLULAR LOCATION: Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.
Q8N3V7	reviewed	SYNPO_HUMAN	Synaptopodin	SYNPO KIAA1029	Homo sapiens (Human)	929	FUNCTION: Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.		modification of dendritic spine [GO:0098886]; positive regulation of actin filament bundle assembly [GO:0032233]; regulation of stress fiber assembly [GO:0051492]; spine apparatus assembly [GO:1905355]	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spine apparatus [GO:0097444]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spine apparatus [GO:0097444]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; modification of dendritic spine [GO:0098886]; positive regulation of actin filament bundle assembly [GO:0032233]; regulation of stress fiber assembly [GO:0051492]; spine apparatus assembly [GO:1905355]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8CC35}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q8CC35}. Perikaryon {ECO:0000250|UniProtKB:Q8CC35}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q8CC35}. Postsynaptic density {ECO:0000250|UniProtKB:Q8CC35}. Synapse {ECO:0000250|UniProtKB:Q8CC35}. Cytoplasm, cytosol {ECO:0000269|PubMed:30661770}. Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses. {ECO:0000250|UniProtKB:Q8CC35}.
Q8N3Y1	reviewed	FBXW8_HUMAN	F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)	FBXW8 FBW6 FBW8 FBX29 FBXO29 FBXW6	Homo sapiens (Human)	598	FUNCTION: Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695}.		cell population proliferation [GO:0008283]; cilium assembly [GO:0060271]; Golgi organization [GO:0007030]; labyrinthine layer blood vessel development [GO:0060716]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; spongiotrophoblast layer development [GO:0060712]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005]		centriole [GO:0005814]; ciliary basal body [GO:0036064]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005]; cell population proliferation [GO:0008283]; cilium assembly [GO:0060271]; Golgi organization [GO:0007030]; labyrinthine layer blood vessel development [GO:0060716]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; spongiotrophoblast layer development [GO:0060712]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:21572988}. Golgi apparatus {ECO:0000269|PubMed:21572988}. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. {ECO:0000250|UniProtKB:P0DL28}.
Q8N3Y3	reviewed	LARG2_HUMAN	Xylosyl- and glucuronyltransferase LARGE2 (EC 2.4.-.-) (Glycosyltransferase-like 1B) (LARGE xylosyl- and glucuronyltransferase 2) [Includes: Alpha-1,3-xylosyltransferase LARGE2 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE2 (EC 2.4.1.-)]	LARGE2 GYLTL1B PP5656	Homo sapiens (Human)	721	FUNCTION: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner (PubMed:15661757, PubMed:15752776, PubMed:25138275). Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Supports the maturation of DAG1 more effectively than LARGE1 (PubMed:15752776). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity). {ECO:0000250|UniProtKB:Q5XPT3, ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15752776, ECO:0000269|PubMed:25138275}.		muscle cell cellular homeostasis [GO:0046716]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	glucuronosyltransferase activity [GO:0015020]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyltransferase activity [GO:0042285]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; glucuronosyltransferase activity [GO:0015020]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyltransferase activity [GO:0042285]; muscle cell cellular homeostasis [GO:0046716]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15661757}; Single-pass type II membrane protein {ECO:0000305}.
Q8N3Y7	reviewed	RDHE2_HUMAN	Epidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5)	SDR16C5 RDHE2	Homo sapiens (Human)	309	FUNCTION: Oxidoreductase with strong preference for NAD (PubMed:18926804). Active in both the oxidative and reductive directions (PubMed:18926804). Oxidizes all-trans-retinol in all-trans-retinaldehyde (PubMed:18926804). No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH (PubMed:18926804). {ECO:0000269|PubMed:18926804}.		keratinocyte proliferation [GO:0043616]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA-binding transcription factor binding [GO:0140297]; NAD-retinol dehydrogenase activity [GO:0004745]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA-binding transcription factor binding [GO:0140297]; NAD-retinol dehydrogenase activity [GO:0004745]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; keratinocyte proliferation [GO:0043616]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18926804}; Multi-pass membrane protein {ECO:0000255}.
Q8N3Z6	reviewed	ZCHC7_HUMAN	Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7)	ZCCHC7 HSPC086	Homo sapiens (Human)	543			nuclear mRNA surveillance of mRNA 3'-end processing [GO:0071031]; nuclear polyadenylation-dependent CUT catabolic process [GO:0071039]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent snoRNA catabolic process [GO:0071036]; nuclear polyadenylation-dependent snRNA catabolic process [GO:0071037]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]	cytosol [GO:0005829]; nucleolus [GO:0005730]; TRAMP complex [GO:0031499]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleolus [GO:0005730]; TRAMP complex [GO:0031499]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; nuclear mRNA surveillance of mRNA 3'-end processing [GO:0071031]; nuclear polyadenylation-dependent CUT catabolic process [GO:0071039]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent snoRNA catabolic process [GO:0071036]; nuclear polyadenylation-dependent snRNA catabolic process [GO:0071037]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21855801}.
Q8N414	reviewed	PGBD5_HUMAN	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac domain-related protein 5) (PiggyBac transposase 5)	PGBD5	Homo sapiens (Human)	524	FUNCTION: Transposase that mediates sequence-specific genomic rearrangements (PubMed:26406119, PubMed:28504702). Can induce genomic rearrangements that inactivate the HPRT1 gene (PubMed:27491780). {ECO:0000269|PubMed:26406119, ECO:0000269|PubMed:27491780, ECO:0000269|PubMed:28504702}.	MISCELLANEOUS: Has been domesticated very early in vertebrate evolution, approximately 500 million years ago, in the common ancestor of cephalochordates and vertebrates. {ECO:0000305|PubMed:24180413}.	non-replicative DNA transposition [GO:0098038]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	endonuclease activity [GO:0004519]; transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; endonuclease activity [GO:0004519]; transposase activity [GO:0004803]; non-replicative DNA transposition [GO:0098038]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24180413}.
Q8N423	reviewed	LIRB2_HUMAN	Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)	LILRB2 ILT4 LIR2 MIR10	Homo sapiens (Human)	597	FUNCTION: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042). Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885). {ECO:0000269|PubMed:11169396, ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:12853576, ECO:0000269|PubMed:16455647, ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:27859042, ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.	MISCELLANEOUS: [Isoform 2]: Alternative use of an acceptor site. {ECO:0000305}.	adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; interleukin-10-mediated signaling pathway [GO:0140105]; learning or memory [GO:0007611]; negative regulation of antigen processing and presentation [GO:0002578]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of postsynaptic density organization [GO:1905875]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of T cell costimulation [GO:2000524]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction [GO:0002645]; regulation of dendritic cell differentiation [GO:2001198]; regulation of long-term synaptic potentiation [GO:1900271]; signal transduction [GO:0007165]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	amyloid-beta binding [GO:0001540]; cell adhesion molecule binding [GO:0050839]; inhibitory MHC class I receptor activity [GO:0032396]; MHC class I protein binding [GO:0042288]; MHC class Ib protein binding [GO:0023029]; MHC class Ib protein complex binding [GO:0023025]; protein homodimerization activity [GO:0042803]; protein phosphatase 1 binding [GO:0008157]; protein-containing complex binding [GO:0044877]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; amyloid-beta binding [GO:0001540]; cell adhesion molecule binding [GO:0050839]; inhibitory MHC class I receptor activity [GO:0032396]; MHC class I protein binding [GO:0042288]; MHC class Ib protein binding [GO:0023029]; MHC class Ib protein complex binding [GO:0023025]; protein homodimerization activity [GO:0042803]; protein phosphatase 1 binding [GO:0008157]; protein-containing complex binding [GO:0044877]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; interleukin-10-mediated signaling pathway [GO:0140105]; learning or memory [GO:0007611]; negative regulation of antigen processing and presentation [GO:0002578]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of postsynaptic density organization [GO:1905875]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of T cell costimulation [GO:2000524]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction [GO:0002645]; regulation of dendritic cell differentiation [GO:2001198]; regulation of long-term synaptic potentiation [GO:1900271]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20448110}; Single-pass type I membrane protein.
Q8N427	reviewed	TXND3_HUMAN	Thioredoxin domain-containing protein 3 (NM23-H8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2) (Sptrx-2)	NME8 SPTRX2 TXNDC3	Homo sapiens (Human)	588	FUNCTION: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.		cell differentiation [GO:0030154]; cellular response to reactive oxygen species [GO:0034614]; cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283]	axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; outer dynein arm [GO:0036157]; sperm cytoplasmic droplet [GO:0097598]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	microtubule binding [GO:0008017]	axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; outer dynein arm [GO:0036157]; sperm cytoplasmic droplet [GO:0097598]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; microtubule binding [GO:0008017]; cell differentiation [GO:0030154]; cellular response to reactive oxygen species [GO:0034614]; cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11737268}.
Q8N428	reviewed	GLT16_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 16 (EC 2.4.1.41) (Polypeptide GalNAc transferase 16) (GalNAc-T16) (Polypeptide GalNAc transferase-like protein 1) (GalNAc-T-like protein 1) (pp-GaNTase-like protein 1) (Polypeptide N-acetylgalactosaminyltransferase-like protein 1) (Protein-UDP acetylgalactosaminyltransferase-like protein 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1)	GALNT16 GALNTL1 KIAA1130	Homo sapiens (Human)	558	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. {ECO:0000269|PubMed:22186971}.		protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q8N441	reviewed	FGRL1_HUMAN	Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (FGF homologous factor receptor) (FGFR-like protein) (Fibroblast growth factor receptor 5) (FGFR-5)	FGFRL1 FGFR5 FHFR UNQ480/PRO943	Homo sapiens (Human)	504	FUNCTION: Has a negative effect on cell proliferation. {ECO:0000250}.		cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; diaphragm development [GO:0060539]; heart valve morphogenesis [GO:0003179]; negative regulation of cell population proliferation [GO:0008285]; skeletal system development [GO:0001501]; ventricular septum morphogenesis [GO:0060412]	cell-cell contact zone [GO:0044291]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]	fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]	cell-cell contact zone [GO:0044291]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; diaphragm development [GO:0060539]; heart valve morphogenesis [GO:0003179]; negative regulation of cell population proliferation [GO:0008285]; skeletal system development [GO:0001501]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12813049}; Single-pass type I membrane protein {ECO:0000269|PubMed:12813049}. Note=Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.
Q8N443	reviewed	RIBC1_HUMAN	RIB43A-like with coiled-coils protein 1	RIBC1	Homo sapiens (Human)	379							
Q8N448	reviewed	LNX2_HUMAN	Ligand of Numb protein X 2 (Numb-binding protein 2) (PDZ domain-containing RING finger protein 1)	LNX2 PDZRN1	Homo sapiens (Human)	690			neural precursor cell proliferation [GO:0061351]; neuron differentiation [GO:0030182]	plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; ubiquitin-protein transferase activity [GO:0004842]	plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; ubiquitin-protein transferase activity [GO:0004842]; neural precursor cell proliferation [GO:0061351]; neuron differentiation [GO:0030182]	
Q8N465	reviewed	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39)	D2HGDH D2HGD	Homo sapiens (Human)	521	FUNCTION: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (PubMed:15070399, PubMed:15609246, PubMed:16037974, PubMed:20020533, PubMed:33431826). Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (PubMed:33431826). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (PubMed:33431826). {ECO:0000269|PubMed:15070399, ECO:0000269|PubMed:15609246, ECO:0000269|PubMed:16037974, ECO:0000269|PubMed:20020533, ECO:0000269|PubMed:33431826}.		2-oxoglutarate metabolic process [GO:0006103]; malate metabolic process [GO:0006108]; protein metabolic process [GO:0019538]; response to cobalt ion [GO:0032025]; response to manganese ion [GO:0010042]; response to zinc ion [GO:0010043]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	(R)-2-hydroxyglutarate dehydrogenase activity [GO:0051990]; FAD binding [GO:0071949]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; (R)-2-hydroxyglutarate dehydrogenase activity [GO:0051990]; FAD binding [GO:0071949]; zinc ion binding [GO:0008270]; 2-oxoglutarate metabolic process [GO:0006103]; malate metabolic process [GO:0006108]; protein metabolic process [GO:0019538]; response to cobalt ion [GO:0032025]; response to manganese ion [GO:0010042]; response to zinc ion [GO:0010043]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:15070399}.
Q8N474	reviewed	SFRP1_HUMAN	Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2)	SFRP1 FRP FRP1 SARP2	Homo sapiens (Human)	314	FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. {ECO:0000250}.	MISCELLANEOUS: May have therapeutic use in cardiac surgery.	BMP signaling pathway [GO:0030509]; bone trabecula formation [GO:0060346]; canonical Wnt signaling pathway [GO:0060070]; cellular response to BMP stimulus [GO:0071773]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heparin [GO:0071504]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin D [GO:0071305]; cellular response to X-ray [GO:0071481]; convergent extension involved in somitogenesis [GO:0090246]; digestive tract morphogenesis [GO:0048546]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; extrinsic apoptotic signaling pathway [GO:0097191]; female gonad development [GO:0008585]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell differentiation [GO:0060218]; male gonad development [GO:0008584]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of bone remodeling [GO:0046851]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [GO:2000080]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin secretion [GO:0046676]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of planar cell polarity pathway involved in axis elongation [GO:2000041]; negative regulation of Wnt signaling pathway [GO:0030178]; negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000054]; neural crest cell fate commitment [GO:0014034]; non-canonical Wnt signaling pathway [GO:0035567]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; planar cell polarity pathway involved in axis elongation [GO:0003402]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of Wnt signaling pathway [GO:0030177]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of angiogenesis [GO:0045765]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of cell cycle process [GO:0010564]; regulation of midbrain dopaminergic neuron differentiation [GO:1904956]; regulation of neuron projection development [GO:0010975]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; somatic stem cell population maintenance [GO:0035019]; stromal-epithelial cell signaling involved in prostate gland development [GO:0044345]; ureteric bud development [GO:0001657]; Wnt signaling pathway involved in somitogenesis [GO:0090244]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cysteine-type endopeptidase activity [GO:0004197]; frizzled binding [GO:0005109]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cysteine-type endopeptidase activity [GO:0004197]; frizzled binding [GO:0005109]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; Wnt-protein binding [GO:0017147]; BMP signaling pathway [GO:0030509]; bone trabecula formation [GO:0060346]; canonical Wnt signaling pathway [GO:0060070]; cellular response to BMP stimulus [GO:0071773]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heparin [GO:0071504]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin D [GO:0071305]; cellular response to X-ray [GO:0071481]; convergent extension involved in somitogenesis [GO:0090246]; digestive tract morphogenesis [GO:0048546]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; extrinsic apoptotic signaling pathway [GO:0097191]; female gonad development [GO:0008585]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell differentiation [GO:0060218]; male gonad development [GO:0008584]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of bone remodeling [GO:0046851]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [GO:2000080]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin secretion [GO:0046676]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of planar cell polarity pathway involved in axis elongation [GO:2000041]; negative regulation of Wnt signaling pathway [GO:0030178]; negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000054]; neural crest cell fate commitment [GO:0014034]; non-canonical Wnt signaling pathway [GO:0035567]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; planar cell polarity pathway involved in axis elongation [GO:0003402]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of Wnt signaling pathway [GO:0030177]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of angiogenesis [GO:0045765]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of cell cycle process [GO:0010564]; regulation of midbrain dopaminergic neuron differentiation [GO:1904956]; regulation of neuron projection development [GO:0010975]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; somatic stem cell population maintenance [GO:0035019]; stromal-epithelial cell signaling involved in prostate gland development [GO:0044345]; ureteric bud development [GO:0001657]; Wnt signaling pathway involved in somitogenesis [GO:0090244]	SUBCELLULAR LOCATION: Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.
Q8N488	reviewed	RYBP_HUMAN	RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)	RYBP DEDAF YEAF1	Homo sapiens (Human)	228	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496, ECO:0000269|PubMed:27748911}.		apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11395500, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:27060496}. Cytoplasm {ECO:0000269|PubMed:11395500, ECO:0000269|PubMed:14765135}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8CCI5}. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity). {ECO:0000250|UniProtKB:Q8CCI5}.
Q8N490	reviewed	PNKD_HUMAN	Probable hydrolase PNKD (EC 3.-.-.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2)	PNKD KIAA1184 MR1 TAHCCP2 FKSG19 UNQ2491/PRO5778	Homo sapiens (Human)	385	FUNCTION: Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. {ECO:0000250}.		methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; negative regulation of neurotransmitter secretion [GO:0046929]; neuromuscular process controlling posture [GO:0050884]; regulation of dopamine metabolic process [GO:0042053]; regulation of synaptic transmission, dopaminergic [GO:0032225]	membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; presynaptic cytosol [GO:0099523]	hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872]	membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; presynaptic cytosol [GO:0099523]; hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; negative regulation of neurotransmitter secretion [GO:0046929]; neuromuscular process controlling posture [GO:0050884]; regulation of dopamine metabolic process [GO:0042053]; regulation of synaptic transmission, dopaminergic [GO:0032225]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane; Peripheral membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion.
Q8N4A0	reviewed	GALT4_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 4 (EC 2.4.1.41) (Polypeptide GalNAc transferase 4) (GalNAc-T4) (pp-GaNTase 4) (Protein-UDP acetylgalactosaminyltransferase 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4)	GALNT4	Homo sapiens (Human)	578	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG. {ECO:0000269|PubMed:10984485, ECO:0000269|PubMed:29208955, ECO:0000269|PubMed:9804815}.		O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]	carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:9804815}; Single-pass type II membrane protein {ECO:0000305|PubMed:9804815}.
Q8N4B1	reviewed	SESQ1_HUMAN	Sesquipedalian-1 (Ses1) (27 kDa inositol polyphosphate phosphatase-interacting protein A) (IPIP27A) (PH domain-containing endocytic trafficking adaptor 1)	PHETA1 FAM109A	Homo sapiens (Human)	249	FUNCTION: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. {ECO:0000269|PubMed:21233288}.	MISCELLANEOUS: Was named after 'sesquipedalian', an unnecessarily long description of a simple thing. {ECO:0000305|PubMed:20133602}.	endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]	protein homodimerization activity [GO:0042803]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; protein homodimerization activity [GO:0042803]; endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:21233288}. Recycling endosome {ECO:0000269|PubMed:21233288}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:21233288}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:21233288}. Note=Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes. {ECO:0000269|PubMed:20133602, ECO:0000269|PubMed:21233288}.
Q8N4C6	reviewed	NIN_HUMAN	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein)	NIN KIAA1565	Homo sapiens (Human)	2090	FUNCTION: Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}.	MISCELLANEOUS: Antibodies against NIN are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins.; MISCELLANEOUS: [Isoform 2]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.	centriole-centriole cohesion [GO:0010457]; centrosome localization [GO:0051642]; centrosome-templated microtubule nucleation [GO:0090222]; collateral sprouting [GO:0048668]; corpus callosum morphogenesis [GO:0021540]; corticospinal tract morphogenesis [GO:0021957]; microtubule anchoring at centrosome [GO:0034454]; positive regulation of axonogenesis [GO:0050772]; protein localization [GO:0008104]	apical part of cell [GO:0045177]; axonal growth cone [GO:0044295]; centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytoplasmic microtubule [GO:0005881]; dendrite [GO:0030425]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]	calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; kinase binding [GO:0019900]; microtubule minus-end binding [GO:0051011]	apical part of cell [GO:0045177]; axonal growth cone [GO:0044295]; centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytoplasmic microtubule [GO:0005881]; dendrite [GO:0030425]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; kinase binding [GO:0019900]; microtubule minus-end binding [GO:0051011]; centriole-centriole cohesion [GO:0010457]; centrosome localization [GO:0051642]; centrosome-templated microtubule nucleation [GO:0090222]; collateral sprouting [GO:0048668]; corpus callosum morphogenesis [GO:0021540]; corticospinal tract morphogenesis [GO:0021957]; microtubule anchoring at centrosome [GO:0034454]; positive regulation of axonogenesis [GO:0050772]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11004522, ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:12927815, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:15190203}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23386061}. Note=Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization. Localizes to the subdistal appendage region of the centriole in a DCTN1-dependent manner. {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:23386061}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000250|UniProtKB:Q61043}. Note=Seems to have a dominant-negative effect on localization of other isoforms, promoting their dissociation from the centrosome. {ECO:0000250|UniProtKB:Q61043}.
Q8N4C7	reviewed	STX19_HUMAN	Syntaxin-19	STX19	Homo sapiens (Human)	294	FUNCTION: Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR). {ECO:0000250|UniProtKB:Q8R1Q0}.		exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]	endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8R1Q0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R1Q0}. Cytoplasm {ECO:0000250|UniProtKB:Q8R1Q0}.
Q8N4C8	reviewed	MINK1_HUMAN	Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)	MINK1 B55 MAP4K6 MINK YSK2 ZC3	Homo sapiens (Human)	1332	FUNCTION: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.		actin cytoskeleton organization [GO:0030036]; brain development [GO:0007420]; chemical synaptic transmission [GO:0007268]; dendrite morphogenesis [GO:0048813]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of AMPA receptor activity [GO:2000311]; regulation of cell migration [GO:0030334]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell-matrix adhesion [GO:0001952]; regulation of MAPK cascade [GO:0043408]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; postsynaptic density [GO:0014069]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; postsynaptic density [GO:0014069]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; actin cytoskeleton organization [GO:0030036]; brain development [GO:0007420]; chemical synaptic transmission [GO:0007268]; dendrite morphogenesis [GO:0048813]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of AMPA receptor activity [GO:2000311]; regulation of cell migration [GO:0030334]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell-matrix adhesion [GO:0001952]; regulation of MAPK cascade [GO:0043408]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15469942, ECO:0000269|PubMed:18930710}. Postsynaptic density {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 4]: Golgi apparatus.
Q8N4E7	reviewed	FTMT_HUMAN	Ferritin, mitochondrial (EC 1.16.3.1)	FTMT	Homo sapiens (Human)	242	FUNCTION: Catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form (PubMed:11323407, PubMed:15201052). Important for iron homeostasis (PubMed:11323407, PubMed:15201052). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:11323407, PubMed:15201052). {ECO:0000269|PubMed:11323407, ECO:0000269|PubMed:15201052}.		intracellular iron ion homeostasis [GO:0006879]; intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826]; positive regulation of aconitate hydratase activity [GO:1904234]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of lyase activity [GO:0051349]; positive regulation of succinate dehydrogenase activity [GO:1904231]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; iron ion binding [GO:0005506]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; iron ion binding [GO:0005506]; intracellular iron ion homeostasis [GO:0006879]; intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826]; positive regulation of aconitate hydratase activity [GO:1904234]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of lyase activity [GO:0051349]; positive regulation of succinate dehydrogenase activity [GO:1904231]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11323407}.
Q8N4F0	reviewed	BPIB2_HUMAN	BPI fold-containing family B member 2 (Bactericidal/permeability-increasing protein-like 1) (BPI-like 1) (Long palate, lung and nasal epithelium carcinoma-associated protein 2) (RYSR)	BPIFB2 BPIL1 C20orf184 LPLUNC2 UNQ2489/PRO5776	Homo sapiens (Human)	458				endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	lipid binding [GO:0008289]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lipid binding [GO:0008289]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q8N4F4	reviewed	S22AO_HUMAN	Steroid transmembrane transporter SLC22A24 (Solute carrier family 22 member 24)	SLC22A24	Homo sapiens (Human)	552	FUNCTION: Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids including estradiol-17beta-D-glucuronide (or 17beta-estradiol 17-O-(beta-D-glucuronate)), androstanediol glucuronide (or 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)), and estrone 3-sulfate, as well as bile acids taurocholate and glycocholate, driven by an outward gradient of dicarboxylates such as glutarate or succinate. {ECO:0000269|PubMed:31553721, ECO:0000305|PubMed:17714910}.; FUNCTION: [Isoform 2]: Similar uptake function as Isoform 1. {ECO:0000269|PubMed:31553721}.; FUNCTION: [Isoform 3]: Lack of transporter activity. {ECO:0000269|PubMed:31553721}.		monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; steroid metabolic process [GO:0008202]; sterol transmembrane transport [GO:0035382]	plasma membrane [GO:0005886]	transmembrane transporter activity [GO:0022857]	plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; steroid metabolic process [GO:0008202]; sterol transmembrane transport [GO:0035382]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:31553721}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:31553721}.
Q8N4J0	reviewed	CARME_HUMAN	Carnosine N-methyltransferase (EC 2.1.1.22)	CARNMT1 C9orf41	Homo sapiens (Human)	409	FUNCTION: N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His). {ECO:0000269|PubMed:26001783}.		carnosine metabolic process [GO:0035498]; histidine catabolic process [GO:0006548]; methylation [GO:0032259]	cytosol [GO:0005829]; nucleus [GO:0005634]	carnosine N-methyltransferase activity [GO:0030735]; protein homodimerization activity [GO:0042803]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	cytosol [GO:0005829]; nucleus [GO:0005634]; carnosine N-methyltransferase activity [GO:0030735]; protein homodimerization activity [GO:0042803]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; carnosine metabolic process [GO:0035498]; histidine catabolic process [GO:0006548]; methylation [GO:0032259]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:26001783}. Nucleus {ECO:0000269|PubMed:26001783}.
Q8N4L1	reviewed	T151A_HUMAN	Transmembrane protein 151A	TMEM151A TMEM151	Homo sapiens (Human)	468				axon [GO:0030424]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]		axon [GO:0030424]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6GQT5}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q6GQT5}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q6GQT5}.
Q8N4L2	reviewed	PP4P2_HUMAN	Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)	PIP4P2 TMEM55A	Homo sapiens (Human)	257	FUNCTION: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity). {ECO:0000250|UniProtKB:Q9CZX7, ECO:0000269|PubMed:16365287}.		negative regulation of phagocytosis [GO:0050765]; phosphatidylinositol dephosphorylation [GO:0046856]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597]; negative regulation of phagocytosis [GO:0050765]; phosphatidylinositol dephosphorylation [GO:0046856]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:16365287}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:16365287}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9CZX7}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9CZX7}; Multi-pass membrane protein {ECO:0000255}.
Q8N4L8	reviewed	CCD24_HUMAN	Coiled-coil domain-containing protein 24	CCDC24	Homo sapiens (Human)	307			blastocyst hatching [GO:0001835]			blastocyst hatching [GO:0001835]	
Q8N4M1	reviewed	CTL3_HUMAN	Choline transporter-like protein 3 (Solute carrier family 44 member 3)	SLC44A3 CTL3 UNQ558/PRO1115	Homo sapiens (Human)	653			phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085]	membrane [GO:0016020]; plasma membrane [GO:0005886]	choline transmembrane transporter activity [GO:0015220]; transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; plasma membrane [GO:0005886]; choline transmembrane transporter activity [GO:0015220]; transmembrane transporter activity [GO:0022857]; phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q8N4N3	reviewed	KLH36_HUMAN	Kelch-like protein 36	KLHL36 C16orf44	Homo sapiens (Human)	616	FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:14528312}.		protein ubiquitination [GO:0016567]		cullin family protein binding [GO:0097602]	cullin family protein binding [GO:0097602]; protein ubiquitination [GO:0016567]	
Q8N4N8	reviewed	KIF2B_HUMAN	Kinesin-like protein KIF2B	KIF2B	Homo sapiens (Human)	673	FUNCTION: Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}.	MISCELLANEOUS: Osteosarcoma cells (U2OS) lacking KIF2B show disorganised often monopolar mitotic spindles, severely reduced velocity of chromosome movement and blocked cytokinesis. Bipolar mitotic spindles can be restored by simultaneous depletion of KIF2B, KIFC1 and NUMA1.	cell division [GO:0051301]; metaphase chromosome alignment [GO:0051310]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; regulation of chromosome segregation [GO:0051983]	centrosome [GO:0005813]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; spindle [GO:0005819]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	centrosome [GO:0005813]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; spindle [GO:0005819]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; cell division [GO:0051301]; metaphase chromosome alignment [GO:0051310]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; regulation of chromosome segregation [GO:0051983]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17538014}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17538014}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17538014}. Note=Association with kinetochore is transient.
Q8N4P3	reviewed	MESH1_HUMAN	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)	HDDC3 MESH1	Homo sapiens (Human)	179	FUNCTION: ppGpp hydrolyzing enzyme involved in starvation response. {ECO:0000269|PubMed:20818390}.				guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity [GO:0008893]; metal ion binding [GO:0046872]	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity [GO:0008893]; metal ion binding [GO:0046872]	
Q8N4Q1	reviewed	MIA40_HUMAN	Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4)	CHCHD4 MIA40	Homo sapiens (Human)	142	FUNCTION: Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (PubMed:26004228). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7 (PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364, PubMed:23676665, PubMed:30885959). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS (PubMed:30885959). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23676665). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864). {ECO:0000269|PubMed:16185709, ECO:0000269|PubMed:19182799, ECO:0000269|PubMed:21059946, ECO:0000269|PubMed:23186364, ECO:0000269|PubMed:23676665, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:26387864, ECO:0000269|PubMed:30885959}.		'de novo' post-translational protein folding [GO:0051084]; mitochondrial respiratory chain complex assembly [GO:0033108]; peptidyl-cysteine oxidation [GO:0018171]; protein import into mitochondrial intermembrane space [GO:0045041]; protein maturation by protein folding [GO:0022417]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]	protein-disulfide reductase activity [GO:0015035]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; protein-disulfide reductase activity [GO:0015035]; 'de novo' post-translational protein folding [GO:0051084]; mitochondrial respiratory chain complex assembly [GO:0033108]; peptidyl-cysteine oxidation [GO:0018171]; protein import into mitochondrial intermembrane space [GO:0045041]; protein maturation by protein folding [GO:0022417]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:16185709, ECO:0000269|PubMed:23186364, ECO:0000269|PubMed:23676665, ECO:0000269|PubMed:26004228}.
Q8N4S9	reviewed	MALD2_HUMAN	MARVEL domain-containing protein 2 (Tricellulin)	MARVELD2 TRIC	Homo sapiens (Human)	558	FUNCTION: Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}.		bicellular tight junction assembly [GO:0070830]; cell-cell junction organization [GO:0045216]; establishment of endothelial barrier [GO:0061028]; sensory perception of sound [GO:0007605]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; paranodal junction [GO:0033010]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160]; tricellular tight junction [GO:0061689]		apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; paranodal junction [GO:0033010]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160]; tricellular tight junction [GO:0061689]; bicellular tight junction assembly [GO:0070830]; cell-cell junction organization [GO:0045216]; establishment of endothelial barrier [GO:0061028]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28661558}; Multi-pass membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000269|PubMed:28661558}. Note=Located at tricellular contacts. {ECO:0000269|PubMed:28661558}.
Q8N4T0	reviewed	CBPA6_HUMAN	Carboxypeptidase A6 (EC 3.4.17.-)	CPA6 CPAH	Homo sapiens (Human)	437	FUNCTION: May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II (PubMed:18178555). Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine (PubMed:20855895). {ECO:0000269|PubMed:18178555, ECO:0000269|PubMed:20855895}.	MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	proteolysis [GO:0006508]	extracellular space [GO:0005615]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	extracellular space [GO:0005615]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18178555}.
Q8N4T8	reviewed	CBR4_HUMAN	3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (Carbonyl reductase family member 4) (CBR4) (Quinone reductase CBR4) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 45C member 1)	CBR4 SDR45C1	Homo sapiens (Human)	237	FUNCTION: Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19000905). As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508). {ECO:0000269|PubMed:19000905, ECO:0000269|PubMed:19571038, ECO:0000269|PubMed:25203508}.		daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; fatty acid biosynthetic process [GO:0006633]; protein heterotetramerization [GO:0051290]; protein homotetramerization [GO:0051289]	mitochondrial matrix [GO:0005759]; oxidoreductase complex [GO:1990204]	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADPH binding [GO:0070402]; NADPH dehydrogenase (quinone) activity [GO:0008753]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; quinone binding [GO:0048038]	mitochondrial matrix [GO:0005759]; oxidoreductase complex [GO:1990204]; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADPH binding [GO:0070402]; NADPH dehydrogenase (quinone) activity [GO:0008753]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; quinone binding [GO:0048038]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; fatty acid biosynthetic process [GO:0006633]; protein heterotetramerization [GO:0051290]; protein homotetramerization [GO:0051289]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:19000905, ECO:0000269|PubMed:19571038}.
Q8N4V1	reviewed	EMC5_HUMAN	ER membrane protein complex subunit 5 (Membrane magnesium transporter 1) (Transmembrane protein 32)	MMGT1 EMC5 TMEM32	Homo sapiens (Human)	131	FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (By similarity). May be involved in Mg(2+) transport (By similarity). {ECO:0000250|UniProtKB:Q8K273, ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}.		copper ion transport [GO:0006825]; magnesium ion transport [GO:0015693]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cobalt ion transmembrane transporter activity [GO:0015087]; ferrous iron transmembrane transporter activity [GO:0015093]; inorganic cation transmembrane transporter activity [GO:0022890]; magnesium ion transmembrane transporter activity [GO:0015095]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cobalt ion transmembrane transporter activity [GO:0015087]; ferrous iron transmembrane transporter activity [GO:0015093]; inorganic cation transmembrane transporter activity [GO:0022890]; magnesium ion transmembrane transporter activity [GO:0015095]; copper ion transport [GO:0006825]; magnesium ion transport [GO:0015693]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Multi-pass membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8K273}; Multi-pass membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}. Early endosome membrane {ECO:0000250|UniProtKB:Q8K273}; Multi-pass membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}.
Q8N4X5	reviewed	AF1L2_HUMAN	Actin filament-associated protein 1-like 2 (AFAP1-like protein 2)	AFAP1L2 KIAA1914 XB130	Homo sapiens (Human)	818	FUNCTION: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}.		inflammatory response [GO:0006954]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of interleukin-8 production [GO:0032757]; regulation of interleukin-6 production [GO:0032675]; regulation of mitotic cell cycle [GO:0007346]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	protein tyrosine kinase activator activity [GO:0030296]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein tyrosine kinase activator activity [GO:0030296]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; inflammatory response [GO:0006954]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of interleukin-8 production [GO:0032757]; regulation of interleukin-6 production [GO:0032675]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17412687}.
Q8N4Y2	reviewed	EFC4A_HUMAN	EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B)	CRACR2B EFCAB4A	Homo sapiens (Human)	399	FUNCTION: Plays a role in store-operated Ca(2+) entry (SOCE). {ECO:0000269|PubMed:20418871}.		regulation of store-operated calcium entry [GO:2001256]; store-operated calcium entry [GO:0002115]	cytoplasm [GO:0005737]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]; regulation of store-operated calcium entry [GO:2001256]; store-operated calcium entry [GO:0002115]	
Q8N511	reviewed	TM199_HUMAN	Transmembrane protein 199	TMEM199 C17orf32	Homo sapiens (Human)	208	FUNCTION: Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833330). {ECO:0000269|PubMed:26833330, ECO:0000269|PubMed:28296633}.		cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	COPI-coated vesicle membrane [GO:0030663]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; lysosome [GO:0005764]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]		COPI-coated vesicle membrane [GO:0030663]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; lysosome [GO:0005764]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:26833330}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:26833330}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:28296633}; Multi-pass membrane protein {ECO:0000255}. Note=Partial colocalization with GOLGB1. {ECO:0000269|PubMed:26833330}.
Q8N539	reviewed	FBCD1_HUMAN	Fibrinogen C domain-containing protein 1	FIBCD1 UNQ701/PRO1346	Homo sapiens (Human)	461	FUNCTION: Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components. {ECO:0000269|PubMed:19710473, ECO:0000269|PubMed:19892701}.			collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; membrane [GO:0016020]	chitin binding [GO:0008061]; metal ion binding [GO:0046872]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; membrane [GO:0016020]; chitin binding [GO:0008061]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8N543	reviewed	OGFD1_HUMAN	Prolyl 3-hydroxylase OGFOD1 (EC 1.14.11.-) (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) (Termination and polyadenylation 1 homolog) (uS12 prolyl 3-hydroxylase)	OGFOD1 KIAA1612 TPA1	Homo sapiens (Human)	542	FUNCTION: Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation. {ECO:0000269|PubMed:20154146, ECO:0000269|PubMed:24550447, ECO:0000269|PubMed:24550462}.		cell population proliferation [GO:0008283]; peptidyl-proline hydroxylation [GO:0019511]; protein hydroxylation [GO:0018126]; regulation of translational termination [GO:0006449]; stress granule assembly [GO:0034063]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 3-dioxygenase activity [GO:0031544]; peptidyl-proline dioxygenase activity [GO:0031543]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 3-dioxygenase activity [GO:0031544]; peptidyl-proline dioxygenase activity [GO:0031543]; cell population proliferation [GO:0008283]; peptidyl-proline hydroxylation [GO:0019511]; protein hydroxylation [GO:0018126]; regulation of translational termination [GO:0006449]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus. Note=Mainly nuclear. A portion relocalizes to cytoplasmic stress granules upon stress.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Q8N554	reviewed	ZN276_HUMAN	Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477)	ZNF276 CENP-Z ZFP276 ZNF477	Homo sapiens (Human)	614	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	chromosome [GO:0005694]; kinetochore [GO:0000776]; nucleus [GO:0005634]	chromatin insulator sequence binding [GO:0043035]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; kinetochore [GO:0000776]; nucleus [GO:0005634]; chromatin insulator sequence binding [GO:0043035]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
Q8N556	reviewed	AFAP1_HUMAN	Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110)	AFAP1 AFAP	Homo sapiens (Human)	730	FUNCTION: Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}.	MISCELLANEOUS: Knockdown in MDA-MB-231 cells resulted in loss of actin stress fibers, decreased adhesion and spreading on fibronectin.		actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]	actin binding [GO:0003779]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; actin binding [GO:0003779]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:15485829}.
Q8N565	reviewed	MREG_HUMAN	Melanoregulin (Dilute suppressor protein homolog)	MREG DSU HDCGA21P	Homo sapiens (Human)	214	FUNCTION: Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity). {ECO:0000250|UniProtKB:Q6NVG5, ECO:0000269|PubMed:19240024}.		melanocyte differentiation [GO:0030318]; melanosome localization [GO:0032400]; melanosome transport [GO:0032402]; minus-end-directed organelle transport along microtubule [GO:0072385]; phagosome maturation [GO:0090382]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; organelle membrane [GO:0031090]; protein-containing complex [GO:0032991]	phosphatidylinositol binding [GO:0035091]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; organelle membrane [GO:0031090]; protein-containing complex [GO:0032991]; phosphatidylinositol binding [GO:0035091]; melanocyte differentiation [GO:0030318]; melanosome localization [GO:0032400]; melanosome transport [GO:0032402]; minus-end-directed organelle transport along microtubule [GO:0072385]; phagosome maturation [GO:0090382]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q6NVG5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NVG5}. Melanosome membrane {ECO:0000250|UniProtKB:Q6NVG5}; Lipid-anchor {ECO:0000250|UniProtKB:Q6NVG5}. Lysosome membrane {ECO:0000250|UniProtKB:Q6NVG5}; Lipid-anchor {ECO:0000250|UniProtKB:Q6NVG5}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q6NVG5}. Note=Localizes to the inner segment and basal outer segment of rods in the retina. {ECO:0000250|UniProtKB:Q6NVG5}.
Q8N568	reviewed	DCLK2_HUMAN	Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)	DCLK2 DCAMKL2 DCDC3B DCK2	Homo sapiens (Human)	766	FUNCTION: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: By homology to mouse isoform 2. {ECO:0000305}.	hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of protein localization to nucleus [GO:1900181]; phosphorylation [GO:0016310]; protein localization to nucleus [GO:0034504]; pyramidal neuron development [GO:0021860]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; ATP binding [GO:0005524]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of protein localization to nucleus [GO:1900181]; phosphorylation [GO:0016310]; protein localization to nucleus [GO:0034504]; pyramidal neuron development [GO:0021860]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. {ECO:0000250}.
Q8N573	reviewed	OXR1_HUMAN	Oxidation resistance protein 1	OXR1 Nbla00307	Homo sapiens (Human)	874	FUNCTION: May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}.		adult walking behavior [GO:0007628]; cellular response to hydroperoxide [GO:0071447]; negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuron apoptotic process [GO:0051402]; response to oxidative stress [GO:0006979]	mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]	oxidoreductase activity [GO:0016491]	mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; oxidoreductase activity [GO:0016491]; adult walking behavior [GO:0007628]; cellular response to hydroperoxide [GO:0071447]; negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuron apoptotic process [GO:0051402]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15060142}.
Q8N594	reviewed	MPND_HUMAN	MPN domain-containing protein (EC 3.4.-.-)	MPND	Homo sapiens (Human)	471	FUNCTION: Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (PubMed:30982744). {ECO:0000250|UniProtKB:Q5VVJ2, ECO:0000269|PubMed:30982744}.		double-strand break repair [GO:0006302]; proteolysis [GO:0006508]	BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]	metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; polyubiquitin modification-dependent protein binding [GO:0031593]	BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; polyubiquitin modification-dependent protein binding [GO:0031593]; double-strand break repair [GO:0006302]; proteolysis [GO:0006508]	
Q8N5A5	reviewed	ZGPAT_HUMAN	Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein)	ZGPAT GPATC6 GPATCH6 KIAA1847 ZC3H9 ZC3HDC9 ZIP	Homo sapiens (Human)	531	FUNCTION: Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of transcription by RNA polymerase II [GO:0000122]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19644445}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000269|PubMed:20233718}.
Q8N5B7	reviewed	CERS5_HUMAN	Ceramide synthase 5 (CerS5) (LAG1 longevity assurance homolog 5) (Sphingoid base N-palmitoyltransferase CERS5) (EC 2.3.1.291) (Sphingosine N-acyltransferase CERS5) (EC 2.3.1.24)	CERS5 LASS5	Homo sapiens (Human)	392	FUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA)(PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:31916624). Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (By similarity). {ECO:0000250|UniProtKB:Q9D6K9, ECO:0000269|PubMed:16951403, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:22144673, ECO:0000269|PubMed:22661289, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068, ECO:0000269|PubMed:31916624}.		ceramide biosynthetic process [GO:0046513]; oligodendrocyte development [GO:0014003]; sphingolipid biosynthetic process [GO:0030148]	endoplasmic reticulum membrane [GO:0005789]	DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291]	endoplasmic reticulum membrane [GO:0005789]; DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291]; ceramide biosynthetic process [GO:0046513]; oligodendrocyte development [GO:0014003]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D6K9}; Multi-pass membrane protein {ECO:0000255}.
Q8N5C8	reviewed	TAB3_HUMAN	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)	TAB3 MAP3K7IP3	Homo sapiens (Human)	712	FUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}.		defense response to bacterium [GO:0042742]; negative regulation of autophagy [GO:0010507]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular adaptor activity [GO:0060090]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular adaptor activity [GO:0060090]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]; defense response to bacterium [GO:0042742]; negative regulation of autophagy [GO:0010507]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	
Q8N5D0	reviewed	WDTC1_HUMAN	WD and tetratricopeptide repeats protein 1	WDTC1 KIAA1037	Homo sapiens (Human)	677	FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16964240}.		cellular response to insulin stimulus [GO:0032869]; glucose metabolic process [GO:0006006]; in utero embryonic development [GO:0001701]; intracellular chemical homeostasis [GO:0055082]; multicellular organism growth [GO:0035264]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of cell size [GO:0008361]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; cellular response to insulin stimulus [GO:0032869]; glucose metabolic process [GO:0006006]; in utero embryonic development [GO:0001701]; intracellular chemical homeostasis [GO:0055082]; multicellular organism growth [GO:0035264]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of cell size [GO:0008361]	
Q8N5D6	reviewed	GBGT1_HUMAN	Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (EC 2.4.1.-) (Forssman glycolipid synthase-like protein)	GBGT1 UNQ2513/PRO6002	Homo sapiens (Human)	347	FUNCTION: Has lost the ability to synthesize Forssman glycolipid antigen (FORS1/FG) (PubMed:10506200). Might have acquired an alternative function in glycosphingolipid metabolism, but it remains to be established. It appears to have drifted more slowly than confirmed pseudogenes in the glycosyltransferase 6 family, suggesting that it has remained under evolutionary pressure. {ECO:0000269|PubMed:10506200, ECO:0000305}.		carbohydrate metabolic process [GO:0005975]; glycolipid biosynthetic process [GO:0009247]; lipid glycosylation [GO:0030259]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; vesicle [GO:0031982]	globoside alpha-N-acetylgalactosaminyltransferase activity [GO:0047277]; metal ion binding [GO:0046872]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; vesicle [GO:0031982]; globoside alpha-N-acetylgalactosaminyltransferase activity [GO:0047277]; metal ion binding [GO:0046872]; carbohydrate metabolic process [GO:0005975]; glycolipid biosynthetic process [GO:0009247]; lipid glycosylation [GO:0030259]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8N5F7	reviewed	NKAP_HUMAN	NF-kappa-B-activating protein	NKAP	Homo sapiens (Human)	415	FUNCTION: Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. {ECO:0000269|PubMed:14550261, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:31587868}.		granulocyte differentiation [GO:0030851]; hematopoietic stem cell proliferation [GO:0071425]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; somatic stem cell population maintenance [GO:0035019]; T cell differentiation in thymus [GO:0033077]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; granulocyte differentiation [GO:0030851]; hematopoietic stem cell proliferation [GO:0071425]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; somatic stem cell population maintenance [GO:0035019]; T cell differentiation in thymus [GO:0033077]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14550261}.
Q8N5G0	reviewed	SIM20_HUMAN	Small integral membrane protein 20 (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa) (MITRAC7) [Cleaved into: Phoenixin-14 (PNX-14); Phoenixin-20 (PNX-20)]	SMIM20 C4orf52 MITRAC7	Homo sapiens (Human)	67	FUNCTION: [Small integral membrane protein 20]: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (PubMed:26321642). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (PubMed:26321642). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (PubMed:26321642). {ECO:0000269|PubMed:26321642}.; FUNCTION: [Phoenixin-14]: Peptide involved in a broad spectrum of regulatory functions (By similarity). Is a ligand for GPR173 (By similarity). As part of the reproductive cycle, it regulates gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary gland which augments the release of luteinizing hormone (By similarity). Plays a protective role in memory retention through activation of GNRHR (By similarity). Regulates the secretion of AVP by hypothalamic neurons (By similarity). Plays a role in the transduction of the itch sensation (By similarity). Induces anxiolytic effects, reducing behavior associated with anxiety (By similarity). Regulates food intake as well as satiation and satiety (By similarity). In the ovary, it regulates follicular growth by stimulating granulosa cell proliferation by increasing the expression of GPR173, CREB1, CYP19A1, KITLG, FSHR, and LHCGR (PubMed:30933929). It also increases the production of estradiol (E2) (PubMed:30933929). In the heart, it regulates contractility and relaxation (By similarity). It also plays a cardioprotective role during ischemia, where it activates the SAFE and RISK pathways (By similarity). Stimulates the proliferation and differentiation of preadipocytes (By similarity). In pancreatic islet cells, it induces proliferation of islet cells as well as the production of INS (By similarity). {ECO:0000250|UniProtKB:C0HLM6, ECO:0000250|UniProtKB:D3Z7Q2, ECO:0000269|PubMed:30933929}.; FUNCTION: [Phoenixin-20]: Peptide involved in a broad spectrum of regulatory functions (By similarity). Is a ligand for GPR173 (By similarity). As part of the reproductive cycle, it regulates gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary gland which augments the release of luteinizing hormone (By similarity). Plays a protective role in memory retention through activation of GNRHR (By similarity). Regulates the secretion of AVP by hypothalamic neurons (By similarity). Plays a role in the transduction of the itch sensation (By similarity). Induces anxiolytic effects, reducing behavior associated with anxiety (By similarity). Regulates food intake as well as satiation and satiety (By similarity). In the ovary, it regulates follicular growth by stimulating granulosa cell proliferation by increasing the expression of GPR173, CREB1, CYP19A1, KITLG, FSHR, and LHCGR (PubMed:30933929). It also increases the production of estradiol (E2) (PubMed:30933929). In the heart, it regulates contractility and relaxation (By similarity). It also plays a cardioprotective role during ischemia, where it activates the SAFE and RISK pathways (By similarity). Stimulates the proliferation and differentiation of preadipocytes (By similarity). In pancreatic islet cells, it induces proliferation of islet cells as well as the production of INS (By similarity). {ECO:0000250|UniProtKB:C0HLM6, ECO:0000250|UniProtKB:D3Z7Q2, ECO:0000269|PubMed:30933929}.	MISCELLANEOUS: [Isoform 2]: Gene prediction. {ECO:0000305}.	mitochondrial cytochrome c oxidase assembly [GO:0033617]	extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]		extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]; mitochondrial cytochrome c oxidase assembly [GO:0033617]	SUBCELLULAR LOCATION: [Small integral membrane protein 20]: Mitochondrion inner membrane {ECO:0000269|PubMed:26321642}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Phoenixin-14]: Secreted {ECO:0000250|UniProtKB:C0HLM6}.; SUBCELLULAR LOCATION: [Phoenixin-20]: Secreted {ECO:0000250|UniProtKB:C0HLM6}.
Q8N5G2	reviewed	MACOI_HUMAN	Macoilin (Macoilin-1) (Transmembrane protein 57)	MACO1 TMEM57	Homo sapiens (Human)	664	FUNCTION: Plays a role in the regulation of neuronal activity. {ECO:0000269|PubMed:21589894}.		brain development [GO:0007420]; chemotaxis [GO:0006935]; neuronal signal transduction [GO:0023041]	axon [GO:0030424]; neuron projection terminus [GO:0044306]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; rough endoplasmic reticulum membrane [GO:0030867]; synapse [GO:0045202]	microtubule binding [GO:0008017]	axon [GO:0030424]; neuron projection terminus [GO:0044306]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; rough endoplasmic reticulum membrane [GO:0030867]; synapse [GO:0045202]; microtubule binding [GO:0008017]; brain development [GO:0007420]; chemotaxis [GO:0006935]; neuronal signal transduction [GO:0023041]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q7TQE6}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q7TQE6}. Rough endoplasmic reticulum membrane {ECO:0000269|PubMed:21589894}; Multi-pass membrane protein {ECO:0000255}. Note=Detected in the nucleus membrane of non-neuronal cells and in axonal outgrowths of neuronal cells. {ECO:0000250|UniProtKB:Q7TQE6}.
Q8N5H7	reviewed	SH2D3_HUMAN	SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)	SH2D3C NSP3 UNQ272/PRO309/PRO34088	Homo sapiens (Human)	860	FUNCTION: Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}.		JNK cascade [GO:0007254]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; small GTPase mediated signal transduction [GO:0007264]	axon [GO:0030424]; cytosol [GO:0005829]; ruffle membrane [GO:0032587]	guanyl-nucleotide exchange factor activity [GO:0005085]; phosphotyrosine residue binding [GO:0001784]	axon [GO:0030424]; cytosol [GO:0005829]; ruffle membrane [GO:0032587]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphotyrosine residue binding [GO:0001784]; JNK cascade [GO:0007254]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17174122}. Cell membrane {ECO:0000269|PubMed:12432078}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9QZS8}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QZS8}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9QZS8}. Note=Associated with the membrane when EGF-stimulated (By similarity). Expressed at the cortical actin ring in B cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:17174122}; Peripheral membrane protein {ECO:0000269|PubMed:17174122}.
Q8N5I2	reviewed	ARRD1_HUMAN	Arrestin domain-containing protein 1 (Alpha-arrestin 1)	ARRDC1	Homo sapiens (Human)	433	FUNCTION: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). {ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:23886940, ECO:0000269|PubMed:27462458}.		extracellular transport [GO:0006858]; extracellular vesicle biogenesis [GO:0140112]; negative regulation of Notch signaling pathway [GO:0045746]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; plasma membrane [GO:0005886]	arrestin family protein binding [GO:1990763]; identical protein binding [GO:0042802]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; plasma membrane [GO:0005886]; arrestin family protein binding [GO:1990763]; identical protein binding [GO:0042802]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]; extracellular transport [GO:0006858]; extracellular vesicle biogenesis [GO:0140112]; negative regulation of Notch signaling pathway [GO:0045746]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:27462458}. Note=Also found in extracellular vesicles different from exosomes. {ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:27462458}.
Q8N5I4	reviewed	DHRSX_HUMAN	Dehydrogenase/reductase SDR family member on chromosome X (EC 1.1.-.-) (DHRSXY) (Short chain dehydrogenase/reductase family 46C member 1) (Short chain dehydrogenase/reductase family 7C member 6)	DHRSX CXorf11 DHRS5X SDR46C1 SDR7C6 UNQ6508/PRO21433	Homo sapiens (Human)	330	FUNCTION: Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851). {ECO:0000269|PubMed:25076851}.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.	positive regulation of autophagy [GO:0010508]	extracellular region [GO:0005576]	oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]; oxidoreductase activity [GO:0016491]; positive regulation of autophagy [GO:0010508]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25076851}. Note=Secreted in a non-classical form. A signal peptide sequence at position 1-31 is predicted.
Q8N5J2	reviewed	MINY1_HUMAN	Ubiquitin carboxyl-terminal hydrolase MINDY-1 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-1) (Protein FAM63A)	MINDY1 FAM63A KIAA1390	Homo sapiens (Human)	469	FUNCTION: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}.		proteolysis [GO:0006508]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	cysteine-type carboxypeptidase activity [GO:0016807]; cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; cysteine-type carboxypeptidase activity [GO:0016807]; cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; proteolysis [GO:0006508]	
Q8N5K1	reviewed	CISD2_HUMAN	CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1)	CISD2 CDGSH2 ERIS ZCD2	Homo sapiens (Human)	135	FUNCTION: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. {ECO:0000269|PubMed:17846994, ECO:0000269|PubMed:20010695}.		autophagy of mitochondrion [GO:0000422]; regulation of autophagy [GO:0010506]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear endoplasmic reticulum [GO:0097038]; protein-containing complex [GO:0032991]	2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear endoplasmic reticulum [GO:0097038]; protein-containing complex [GO:0032991]; 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; autophagy of mitochondrion [GO:0000422]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note=According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.
Q8N5M1	reviewed	ATPF2_HUMAN	ATP synthase mitochondrial F1 complex assembly factor 2 (ATP12 homolog)	ATPAF2 ATP12 LP3663	Homo sapiens (Human)	289	FUNCTION: May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase). {ECO:0000269|PubMed:11410595}.		mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; proton-transporting ATP synthase complex assembly [GO:0043461]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]		cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; proton-transporting ATP synthase complex assembly [GO:0043461]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q8N5M9	reviewed	JAGN1_HUMAN	Protein jagunal homolog 1	JAGN1	Homo sapiens (Human)	183	FUNCTION: Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils. {ECO:0000269|PubMed:25129144, ECO:0000305}.		defense response to fungus [GO:0050832]; endoplasmic reticulum organization [GO:0007029]; exocytosis [GO:0006887]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; neutrophil differentiation [GO:0030223]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; defense response to fungus [GO:0050832]; endoplasmic reticulum organization [GO:0007029]; exocytosis [GO:0006887]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; neutrophil differentiation [GO:0030223]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25129144}; Multi-pass membrane protein {ECO:0000255}.
Q8N5P1	reviewed	ZC3H8_HUMAN	Zinc finger CCCH domain-containing protein 8	ZC3H8 ZC3HDC8	Homo sapiens (Human)	291	FUNCTION: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}.		apoptotic process [GO:0006915]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of T cell differentiation in thymus [GO:0033085]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of transcription by RNA polymerase III [GO:0045945]; response to antibiotic [GO:0046677]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; T cell homeostasis [GO:0043029]	Cajal body [GO:0015030]; chromatin [GO:0000785]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]	Cajal body [GO:0015030]; chromatin [GO:0000785]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; apoptotic process [GO:0006915]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of T cell differentiation in thymus [GO:0033085]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of transcription by RNA polymerase III [GO:0045945]; response to antibiotic [GO:0046677]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; T cell homeostasis [GO:0043029]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23932780}. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
Q8N5S9	reviewed	KKCC1_HUMAN	Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha)	CAMKK1 CAMKKA	Homo sapiens (Human)	505	FUNCTION: Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}.		intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q8N5U6	reviewed	RNF10_HUMAN	E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10)	RNF10 KIAA0262 RIE2	Homo sapiens (Human)	811	FUNCTION: E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731). Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity). {ECO:0000250|UniProtKB:Q5XI59, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731}.		negative regulation of Schwann cell proliferation [GO:0010626]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myelination [GO:0031643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynapse to nucleus signaling pathway [GO:0099527]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of Schwann cell proliferation [GO:0010626]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myelination [GO:0031643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynapse to nucleus signaling pathway [GO:0099527]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16335786}. Nucleus {ECO:0000250|UniProtKB:Q5XI59}.
Q8N5V2	reviewed	NGEF_HUMAN	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)	NGEF	Homo sapiens (Human)	710	FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of dendritic spine morphogenesis [GO:0061002]; nervous system development [GO:0007399]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020]; guanyl-nucleotide exchange factor activity [GO:0005085]; cell differentiation [GO:0030154]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of dendritic spine morphogenesis [GO:0061002]; nervous system development [GO:0007399]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Associated with membranes. Localizes to axonal growth cones (By similarity). {ECO:0000250}.
Q8N5Y2	reviewed	MS3L1_HUMAN	Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1)	MSL3 MSL3L1	Homo sapiens (Human)	521	FUNCTION: Has a role in chromatin remodeling and transcriptional regulation (PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647). Has a role in X inactivation (PubMed:21217699). Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure (PubMed:16227571, PubMed:20657587, PubMed:16543150, PubMed:30224647). Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). {ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30224647}.	MISCELLANEOUS: MSL3L1 gene undergoes X inactivation.	positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	MSL complex [GO:0072487]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone H4K16 acetyltransferase activity [GO:0046972]; methylated histone binding [GO:0035064]	MSL complex [GO:0072487]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone H4K16 acetyltransferase activity [GO:0046972]; methylated histone binding [GO:0035064]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30224647}.
Q8N5Y8	reviewed	PAR16_HUMAN	Protein mono-ADP-ribosyltransferase PARP16 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 15) (Poly [ADP-ribose] polymerase 16) (PARP-16)	PARP16 ARTD15 C15orf30	Homo sapiens (Human)	322	FUNCTION: Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:22701565, PubMed:23103912, PubMed:25043379, PubMed:34314702). Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading (PubMed:34314702). Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2 (PubMed:34314702). Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565). {ECO:0000269|PubMed:22701565, ECO:0000269|PubMed:23103912, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:34314702}.		cellular response to leukemia inhibitory factor [GO:1990830]; endoplasmic reticulum unfolded protein response [GO:0030968]; IRE1-mediated unfolded protein response [GO:0036498]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of cytoplasmic translation [GO:2000766]; protein auto-ADP-ribosylation [GO:0070213]; viral protein processing [GO:0019082]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; nuclear envelope [GO:0005635]	kinase binding [GO:0019900]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+- protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; nucleotidyltransferase activity [GO:0016779]; protein serine/threonine kinase activator activity [GO:0043539]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; kinase binding [GO:0019900]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+- protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; nucleotidyltransferase activity [GO:0016779]; protein serine/threonine kinase activator activity [GO:0043539]; cellular response to leukemia inhibitory factor [GO:1990830]; endoplasmic reticulum unfolded protein response [GO:0030968]; IRE1-mediated unfolded protein response [GO:0036498]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of cytoplasmic translation [GO:2000766]; protein auto-ADP-ribosylation [GO:0070213]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23103912}; Single-pass type IV membrane protein {ECO:0000269|PubMed:22701565}.
Q8N5Z0	reviewed	AADAT_HUMAN	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (KAT/AadAT) (2-aminoadipate aminotransferase) (2-aminoadipate transaminase) (EC 2.6.1.39) (Alpha-aminoadipate aminotransferase) (AadAT) (Glycine transaminase AADAT) (EC 2.6.1.4) (Kynurenine aminotransferase II) (Kynurenine--glyoxylate transaminase AADAT) (EC 2.6.1.63) (Kynurenine--oxoglutarate aminotransferase II) (Kynurenine--oxoglutarate transaminase 2) (EC 2.6.1.7) (Kynurenine--oxoglutarate transaminase II) (Methionine--glyoxylate transaminase AADAT) (EC 2.6.1.73)	AADAT KAT2 KYAT2	Homo sapiens (Human)	425	FUNCTION: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). {ECO:0000269|PubMed:12126930, ECO:0000269|PubMed:18056995, ECO:0000269|PubMed:18620547}.	MISCELLANEOUS: [Isoform 1]: May be due to a competing donor splice site.	2-oxoglutarate metabolic process [GO:0006103]; alpha-amino acid metabolic process [GO:1901605]; biosynthetic process [GO:0009058]; glutamate metabolic process [GO:0006536]; kynurenine metabolic process [GO:0070189]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]	mitochondrial matrix [GO:0005759]	2-aminoadipate transaminase activity [GO:0047536]; glycine:2-oxoglutarate aminotransferase activity [GO:0047958]; kynurenine-glyoxylate transaminase activity [GO:0047315]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; methionine-glyoxylate transaminase activity [GO:0050094]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]	mitochondrial matrix [GO:0005759]; 2-aminoadipate transaminase activity [GO:0047536]; glycine:2-oxoglutarate aminotransferase activity [GO:0047958]; kynurenine-glyoxylate transaminase activity [GO:0047315]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; methionine-glyoxylate transaminase activity [GO:0050094]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; 2-oxoglutarate metabolic process [GO:0006103]; alpha-amino acid metabolic process [GO:1901605]; biosynthetic process [GO:0009058]; glutamate metabolic process [GO:0006536]; kynurenine metabolic process [GO:0070189]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q8N5Z5	reviewed	KCD17_HUMAN	BTB/POZ domain-containing protein KCTD17	KCTD17	Homo sapiens (Human)	321	FUNCTION: Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243). {ECO:0000269|PubMed:25270598, ECO:0000269|PubMed:25983243}.		cell projection organization [GO:0030030]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; positive regulation of cilium assembly [GO:0045724]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]	cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]; cell projection organization [GO:0030030]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; positive regulation of cilium assembly [GO:0045724]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25983243}.
Q8N608	reviewed	DPP10_HUMAN	Inactive dipeptidyl peptidase 10 (Dipeptidyl peptidase IV-related protein 3) (DPRP-3) (Dipeptidyl peptidase X) (DPP X) (Dipeptidyl peptidase-like protein 2) (DPL2)	DPP10 DPRP3 KIAA1492	Homo sapiens (Human)	796	FUNCTION: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155). {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:15671030}.		positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; proteolysis [GO:0006508]; regulation of potassium ion transmembrane transport [GO:1901379]	membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	potassium channel regulator activity [GO:0015459]; serine-type peptidase activity [GO:0008236]; transmembrane transporter binding [GO:0044325]	membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; potassium channel regulator activity [GO:0015459]; serine-type peptidase activity [GO:0008236]; transmembrane transporter binding [GO:0044325]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; proteolysis [GO:0006508]; regulation of potassium ion transmembrane transport [GO:1901379]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6NXK7, ECO:0000269|PubMed:14566338}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P42658}.
Q8N609	reviewed	TR1L1_HUMAN	Translocating chain-associated membrane protein 1-like 1	TRAM1L1	Homo sapiens (Human)	369	FUNCTION: Stimulatory or required for the translocation of secretory proteins across the ER membrane. {ECO:0000250}.		protein insertion into ER membrane [GO:0045048]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]; protein insertion into ER membrane [GO:0045048]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q8N612	reviewed	FHI1B_HUMAN	FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP)	FHIP1B C11orf56 FAM160A2 KIAA1759	Homo sapiens (Human)	972	FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}.		early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031]	cytosol [GO:0005829]; FHF complex [GO:0070695]		cytosol [GO:0005829]; FHF complex [GO:0070695]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031]	
Q8N635	reviewed	MEIOB_HUMAN	Meiosis-specific with OB domain-containing protein (EC 3.1.-.-)	MEIOB C16orf73	Homo sapiens (Human)	442	FUNCTION: Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro. {ECO:0000250|UniProtKB:Q9D513}.		double-strand break repair via homologous recombination [GO:0000724]; female meiosis I [GO:0007144]; fertilization [GO:0009566]; homologous chromosome pairing at meiosis [GO:0007129]; male meiotic nuclear division [GO:0007140]; resolution of meiotic recombination intermediates [GO:0000712]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; single-stranded DNA binding [GO:0003697]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; single-stranded DNA binding [GO:0003697]; double-strand break repair via homologous recombination [GO:0000724]; female meiosis I [GO:0007144]; fertilization [GO:0009566]; homologous chromosome pairing at meiosis [GO:0007129]; male meiotic nuclear division [GO:0007140]; resolution of meiotic recombination intermediates [GO:0000712]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D513}. Nucleus {ECO:0000250|UniProtKB:Q9D513}. Chromosome {ECO:0000250|UniProtKB:Q9D513}. Note=Co-localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22. {ECO:0000250|UniProtKB:Q9D513}.
Q8N653	reviewed	LZTR1_HUMAN	Leucine-zipper-like transcriptional regulator 1 (LZTR-1)	LZTR1 TCFL2	Homo sapiens (Human)	840	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304). {ECO:0000269|PubMed:30442762, ECO:0000269|PubMed:30442766, ECO:0000269|PubMed:30481304}.		negative regulation of Ras protein signal transduction [GO:0046580]; protein ubiquitination [GO:0016567]	Cul3-RING ubiquitin ligase complex [GO:0031463]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; recycling endosome membrane [GO:0055038]	small GTPase binding [GO:0031267]	Cul3-RING ubiquitin ligase complex [GO:0031463]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; recycling endosome membrane [GO:0055038]; small GTPase binding [GO:0031267]; negative regulation of Ras protein signal transduction [GO:0046580]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:30442762, ECO:0000269|PubMed:30442766}. Recycling endosome {ECO:0000269|PubMed:30442762}. Golgi apparatus {ECO:0000269|PubMed:16356934, ECO:0000269|PubMed:30481304, ECO:0000269|PubMed:34626534}.
Q8N661	reviewed	TM86B_HUMAN	Lysoplasmalogenase TMEM86B (EC 3.3.2.2) (Transmembrane protein 86B)	TMEM86B	Homo sapiens (Human)	226	FUNCTION: Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen. {ECO:0000269|PubMed:21515882}.		ether lipid metabolic process [GO:0046485]; phosphatidylcholine acyl-chain remodeling [GO:0036151]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	alkenylglycerophosphocholine hydrolase activity [GO:0047408]; alkenylglycerophosphoethanolamine hydrolase activity [GO:0047409]; ether hydrolase activity [GO:0016803]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; alkenylglycerophosphocholine hydrolase activity [GO:0047408]; alkenylglycerophosphoethanolamine hydrolase activity [GO:0047409]; ether hydrolase activity [GO:0016803]; identical protein binding [GO:0042802]; ether lipid metabolic process [GO:0046485]; phosphatidylcholine acyl-chain remodeling [GO:0036151]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D8N3}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:21515882}.
Q8N668	reviewed	COMD1_HUMAN	COMM domain-containing protein 1 (Protein Murr1)	COMMD1 C2orf5 MURR1	Homo sapiens (Human)	190	FUNCTION: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141). Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner (PubMed:28604741). {ECO:0000269|PubMed:14645214, ECO:0000269|PubMed:14685266, ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520, ECO:0000269|PubMed:17183367, ECO:0000269|PubMed:17309234, ECO:0000269|PubMed:20048074, ECO:0000269|PubMed:20237237, ECO:0000269|PubMed:20458141, ECO:0000269|PubMed:20595380, ECO:0000269|PubMed:21483833, ECO:0000269|PubMed:21741370, ECO:0000269|PubMed:21778237, ECO:0000269|PubMed:23515529, ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28604741}.		copper ion homeostasis [GO:0055070]; Golgi to plasma membrane transport [GO:0006893]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sodium ion transmembrane transport [GO:1902306]; nucleotide-excision repair [GO:0006289]; plasma membrane to endosome transport [GO:0048227]; positive regulation of protein ubiquitination [GO:0031398]; protein transport [GO:0015031]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; recycling endosome [GO:0055037]	copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein homodimerization activity [GO:0042803]; sodium channel inhibitor activity [GO:0019871]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; recycling endosome [GO:0055037]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein homodimerization activity [GO:0042803]; sodium channel inhibitor activity [GO:0019871]; copper ion homeostasis [GO:0055070]; Golgi to plasma membrane transport [GO:0006893]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sodium ion transmembrane transport [GO:1902306]; nucleotide-excision repair [GO:0006289]; plasma membrane to endosome transport [GO:0048227]; positive regulation of protein ubiquitination [GO:0031398]; protein transport [GO:0015031]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21778237, ECO:0000269|PubMed:28604741}. Cytoplasm {ECO:0000269|PubMed:21778237}. Endosome membrane {ECO:0000269|PubMed:18940794}. Cytoplasmic vesicle {ECO:0000269|PubMed:18940794}. Early endosome {ECO:0000269|PubMed:21483833, ECO:0000269|PubMed:25355947}. Recycling endosome {ECO:0000269|PubMed:21483833, ECO:0000269|PubMed:21741370}. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins.
Q8N680	reviewed	ZBTB2_HUMAN	Zinc finger and BTB domain-containing protein 2	ZBTB2 KIAA1483 ZNF437	Homo sapiens (Human)	514	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	nucleoplasm [GO:0005654]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleoplasm [GO:0005654]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N682	reviewed	DRAM1_HUMAN	DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator)	DRAM1 DRAM	Homo sapiens (Human)	238	FUNCTION: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. {ECO:0000269|PubMed:16839881, ECO:0000269|PubMed:17304243}.		apoptotic process [GO:0006915]; autophagy [GO:0006914]; regulation of autophagy [GO:0010506]	cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]		cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; apoptotic process [GO:0006915]; autophagy [GO:0006914]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:16839881}; Multi-pass membrane protein {ECO:0000269|PubMed:16839881}.
Q8N684	reviewed	CPSF7_HUMAN	Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit)	CPSF7	Homo sapiens (Human)	471	FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:8626397, PubMed:17024186, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:8626397, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:8626397, PubMed:17024186). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}.		messenger ribonucleoprotein complex assembly [GO:1990120]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]	cytoplasm [GO:0005737]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; messenger ribonucleoprotein complex assembly [GO:1990120]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19864460, ECO:0000305|PubMed:20695905}. Cytoplasm {ECO:0000269|PubMed:19864460}. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). {ECO:0000269|PubMed:19864460}.
Q8N693	reviewed	ESX1_HUMAN	Homeobox protein ESX1 (Extraembryonic, spermatogenesis, homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C]	ESX1 ESX1L ESX1R	Homo sapiens (Human)	406	FUNCTION: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. {ECO:0000269|PubMed:15235584, ECO:0000269|PubMed:15897875}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15235584}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15235584}. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Q8N695	reviewed	SC5A8_HUMAN	Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8)	SLC5A8 AIT SMCT SMCT1	Homo sapiens (Human)	610	FUNCTION: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 (PubMed:14966140, PubMed:15090606, PubMed:17178845, PubMed:16805814, PubMed:16729224, PubMed:17526579, PubMed:17245649, PubMed:20211600, PubMed:30604288). Catalyzes passive carrier mediated diffusion of iodide (PubMed:12107270). Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (PubMed:12107270). May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract (PubMed:17245649). Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines (PubMed:12829793, PubMed:15867356, PubMed:18037591). May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons (PubMed:16805814). Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) (PubMed:20211600). Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced (PubMed:19864324). {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:12829793, ECO:0000269|PubMed:14966140, ECO:0000269|PubMed:15090606, ECO:0000269|PubMed:15867356, ECO:0000269|PubMed:16729224, ECO:0000269|PubMed:16805814, ECO:0000269|PubMed:17178845, ECO:0000269|PubMed:17245649, ECO:0000269|PubMed:17526579, ECO:0000269|PubMed:18037591, ECO:0000269|PubMed:19864324, ECO:0000269|PubMed:20211600, ECO:0000269|PubMed:30604288}.		acetate transport [GO:0006846]; apoptotic process [GO:0006915]; chloride transport [GO:0006821]; iodide transport [GO:0015705]; lactate transport [GO:0015727]; monoatomic ion transport [GO:0006811]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinate transport [GO:2001142]; nitrate transmembrane transport [GO:0015706]; propanoate transmembrane transport [GO:0015730]; pyruvate transport [GO:0006848]; sodium ion transport [GO:0006814]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; GINS complex [GO:0000811]; plasma membrane [GO:0005886]	lactate transmembrane transporter activity [GO:0015129]; monocarboxylate:sodium symporter activity [GO:0140161]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; organic acid:sodium symporter activity [GO:0005343]; passive transmembrane transporter activity [GO:0022803]; propionate transmembrane transporter activity [GO:0015552]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; GINS complex [GO:0000811]; plasma membrane [GO:0005886]; lactate transmembrane transporter activity [GO:0015129]; monocarboxylate:sodium symporter activity [GO:0140161]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; organic acid:sodium symporter activity [GO:0005343]; passive transmembrane transporter activity [GO:0022803]; propionate transmembrane transporter activity [GO:0015552]; acetate transport [GO:0006846]; apoptotic process [GO:0006915]; chloride transport [GO:0006821]; iodide transport [GO:0015705]; lactate transport [GO:0015727]; monoatomic ion transport [GO:0006811]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinate transport [GO:2001142]; nitrate transmembrane transport [GO:0015706]; propanoate transmembrane transport [GO:0015730]; pyruvate transport [GO:0006848]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:15001644, ECO:0000269|PubMed:17245649}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells. {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:15001644, ECO:0000269|PubMed:17245649}.
Q8N697	reviewed	S15A4_HUMAN	Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1)	SLC15A4 PHT1 PTR4 FP12591	Homo sapiens (Human)	577	FUNCTION: Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). {ECO:0000250|UniProtKB:O09014, ECO:0000250|UniProtKB:Q91W98, ECO:0000269|PubMed:16289537, ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:32433612}.		dipeptide import across plasma membrane [GO:0140206]; histidine transport [GO:0015817]; innate immune response [GO:0045087]; L-histidine transmembrane export from vacuole [GO:0089708]; mast cell homeostasis [GO:0033023]; monoatomic ion transport [GO:0006811]; peptidoglycan transport [GO:0015835]; positive regulation of innate immune response [GO:0045089]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 8 signaling pathway [GO:0034161]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; protein transport [GO:0015031]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]	early endosome membrane [GO:0031901]; endolysosome membrane [GO:0036020]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	dipeptide transmembrane transporter activity [GO:0071916]; L-histidine transmembrane transporter activity [GO:0005290]; peptide:proton symporter activity [GO:0015333]; peptidoglycan transmembrane transporter activity [GO:0015647]	early endosome membrane [GO:0031901]; endolysosome membrane [GO:0036020]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; dipeptide transmembrane transporter activity [GO:0071916]; L-histidine transmembrane transporter activity [GO:0005290]; peptide:proton symporter activity [GO:0015333]; peptidoglycan transmembrane transporter activity [GO:0015647]; dipeptide import across plasma membrane [GO:0140206]; histidine transport [GO:0015817]; innate immune response [GO:0045087]; L-histidine transmembrane export from vacuole [GO:0089708]; mast cell homeostasis [GO:0033023]; monoatomic ion transport [GO:0006811]; peptidoglycan transport [GO:0015835]; positive regulation of innate immune response [GO:0045089]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 8 signaling pathway [GO:0034161]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; protein transport [GO:0015031]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:32433612}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:32433612}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q91W98}; Multi-pass membrane protein {ECO:0000255}.
Q8N6C5	reviewed	IGSF1_HUMAN	Immunoglobulin superfamily member 1 (IgSF1) (Immunoglobulin-like domain-containing protein 1) (Inhibin-binding protein) (InhBP) (Pituitary gland-specific factor 2) (p120)	IGSF1 IGDC1 KIAA0364 PGSF2	Homo sapiens (Human)	1336	FUNCTION: Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription. {ECO:0000250, ECO:0000269|PubMed:11266516}.		negative regulation of activin receptor signaling pathway [GO:0032926]; regulation of DNA-templated transcription [GO:0006355]	extracellular region [GO:0005576]; membrane [GO:0016020]	activin receptor antagonist activity [GO:0038102]; inhibin binding [GO:0034711]	extracellular region [GO:0005576]; membrane [GO:0016020]; activin receptor antagonist activity [GO:0038102]; inhibin binding [GO:0034711]; negative regulation of activin receptor signaling pathway [GO:0032926]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.
Q8N6C8	reviewed	LIRA3_HUMAN	Leukocyte immunoglobulin-like receptor subfamily A member 3 (CD85 antigen-like family member E) (Immunoglobulin-like transcript 6) (ILT-6) (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Monocyte inhibitory receptor HM43/HM31) (CD antigen CD85e)	LILRA3 ILT6 LIR4	Homo sapiens (Human)	439	FUNCTION: Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes. {ECO:0000269|PubMed:21559424, ECO:0000269|PubMed:24085305}.		adaptive immune response [GO:0002250]; cytokine-mediated signaling pathway [GO:0019221]	extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	inhibitory MHC class I receptor activity [GO:0032396]	extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; inhibitory MHC class I receptor activity [GO:0032396]; adaptive immune response [GO:0002250]; cytokine-mediated signaling pathway [GO:0019221]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N6D2	reviewed	RN182_HUMAN	E3 ubiquitin-protein ligase RNF182 (EC 2.3.2.27) (RING finger protein 182) (RING-type E3 ubiquitin transferase RNF182)	RNF182	Homo sapiens (Human)	247	FUNCTION: E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway (PubMed:18298843). Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA (PubMed:31432514). {ECO:0000269|PubMed:18298843, ECO:0000269|PubMed:31432514}.		protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; membrane [GO:0016020]	metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18298843, ECO:0000269|PubMed:31432514}.
Q8N6F1	reviewed	CLD19_HUMAN	Claudin-19	CLDN19	Homo sapiens (Human)	224	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250|UniProtKB:Q9ET38}.		actin cytoskeleton organization [GO:0030036]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of wound healing [GO:0061045]; neuronal action potential propagation [GO:0019227]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of transepithelial transport [GO:0150111]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	apical junction complex [GO:0043296]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	apical junction complex [GO:0043296]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; actin cytoskeleton organization [GO:0030036]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of wound healing [GO:0061045]; neuronal action potential propagation [GO:0019227]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of transepithelial transport [GO:0150111]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Q8N6F7	reviewed	GCSAM_HUMAN	Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL)	GCSAM GAL GCET2	Homo sapiens (Human)	178	FUNCTION: Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}.		negative regulation of lymphocyte migration [GO:2000402]; regulation of B cell receptor signaling pathway [GO:0050855]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; myosin II binding [GO:0045159]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; myosin II binding [GO:0045159]; protein kinase binding [GO:0019901]; negative regulation of lymphocyte migration [GO:2000402]; regulation of B cell receptor signaling pathway [GO:0050855]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane {ECO:0000269|PubMed:31570756}. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
Q8N6F8	reviewed	MET27_HUMAN	Methyltransferase-like protein 27 (Williams-Beuren syndrome chromosomal region 27 protein)	METTL27 WBSCR27	Homo sapiens (Human)	245			metabolic process [GO:0008152]		S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; metabolic process [GO:0008152]	
Q8N6G5	reviewed	CGAT2_HUMAN	Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2) (Beta4GalNAcT-2) (GalNAcT-2)	CSGALNACT2 CHGN2 GALNACT2 PRO0082	Homo sapiens (Human)	542	FUNCTION: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. {ECO:0000269|PubMed:12433924, ECO:0000269|PubMed:12446672}.		chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050653]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050652]; proteoglycan biosynthetic process [GO:0030166]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	acetylgalactosaminyltransferase activity [GO:0008376]; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047237]; metal ion binding [GO:0046872]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; acetylgalactosaminyltransferase activity [GO:0008376]; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047237]; metal ion binding [GO:0046872]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050653]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050652]; proteoglycan biosynthetic process [GO:0030166]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8N6G6	reviewed	ATL1_HUMAN	ADAMTS-like protein 1 (ADAMTSL-1) (Punctin-1)	ADAMTSL1 ADAMTSR1 C9orf94 UNQ528/PRO1071	Homo sapiens (Human)	1762		MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	extracellular matrix organization [GO:0030198]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]	hydrolase activity [GO:0016787]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; hydrolase activity [GO:0016787]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11805097, ECO:0000269|PubMed:17395588, ECO:0000269|PubMed:19671700}.
Q8N6H7	reviewed	ARFG2_HUMAN	ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289)	ARFGAP2 ZNF289 Nbla10535	Homo sapiens (Human)	521	FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}.	MISCELLANEOUS: Vero cells overexpressing truncated ARFGAP2 show accumulation of cholera toxin A subunit in the Golgi complex rather than the endoplasmic reticulum.	COPI coating of Golgi vesicle [GO:0048205]; protein transport [GO:0015031]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; COPI coating of Golgi vesicle [GO:0048205]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17760859}. Golgi apparatus membrane {ECO:0000269|PubMed:17760859}; Peripheral membrane protein {ECO:0000269|PubMed:17760859}; Cytoplasmic side {ECO:0000269|PubMed:17760859}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.
Q8N6I1	reviewed	EID2_HUMAN	EP300-interacting inhibitor of differentiation 2 (EID-2) (CREBBP/EP300 inhibitor 2) (EID-1-like inhibitor of differentiation 2)	EID2 CRI2	Homo sapiens (Human)	236	FUNCTION: Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex. {ECO:0000269|PubMed:12586827, ECO:0000269|PubMed:14585496, ECO:0000269|PubMed:14612439}.		cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of cell population proliferation [GO:0042127]; transforming growth factor beta receptor complex assembly [GO:0007181]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	SMAD binding [GO:0046332]; transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMAD binding [GO:0046332]; transcription corepressor activity [GO:0003714]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of cell population proliferation [GO:0042127]; transforming growth factor beta receptor complex assembly [GO:0007181]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14585496}.
Q8N6I4	reviewed	LYSET_HUMAN	Lysosomal enzyme trafficking factor (GNPTAB cleavage and activity factor) (GCAF) (Transmembrane protein 251)	LYSET C14orf109 TMEM251	Homo sapiens (Human)	163	FUNCTION: Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes (PubMed:36074822, PubMed:36096887, PubMed:36074821). LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes (PubMed:36096887, PubMed:36074822, PubMed:36074821). LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases (PubMed:36074822). {ECO:0000269|PubMed:36074821, ECO:0000269|PubMed:36074822, ECO:0000269|PubMed:36096887}.; FUNCTION: (Microbial infection) Essential for infection by muliple viruses, including SARS-CoV-2, that utilize activated cathepsins for entry after M6P-dependent lysosomal transport. {ECO:0000269|PubMed:36074821}.		lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; regulation of vesicle-mediated transport [GO:0060627]	Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]		Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; regulation of vesicle-mediated transport [GO:0060627]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:33252156, ECO:0000269|PubMed:36074821, ECO:0000269|PubMed:36096887}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with GNPTAB and GNPTG in Golgi apparatus cisternae. {ECO:0000269|PubMed:36074821}.
Q8N6K0	reviewed	TEX29_HUMAN	Testis-expressed protein 29	TEX29 C13orf16	Homo sapiens (Human)	151				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8N6K7	reviewed	SAMD3_HUMAN	Sterile alpha motif domain-containing protein 3 (SAM domain-containing protein 3)	SAMD3	Homo sapiens (Human)	520							
Q8N6L0	reviewed	KASH5_HUMAN	Protein KASH5 (Coiled-coil domain-containing protein 155) (KASH domain-containing protein 5)	KASH5 CCDC155	Homo sapiens (Human)	562	FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation. {ECO:0000250|UniProtKB:Q80VJ8}.		actin filament organization [GO:0007015]; chromosome localization to nuclear envelope involved in homologous chromosome segregation [GO:0090220]; double-strand break repair via homologous recombination [GO:0000724]; homologous chromosome pairing at meiosis [GO:0007129]; microtubule cytoskeleton organization involved in homologous chromosome segregation [GO:0090172]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]; spindle assembly [GO:0051225]; spindle localization [GO:0051653]; telomere localization [GO:0034397]	chromosome, telomeric region [GO:0000781]; lateral element [GO:0000800]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; meiotic spindle pole [GO:0090619]; nuclear outer membrane [GO:0005640]	dynein complex binding [GO:0070840]; identical protein binding [GO:0042802]	chromosome, telomeric region [GO:0000781]; lateral element [GO:0000800]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; meiotic spindle pole [GO:0090619]; nuclear outer membrane [GO:0005640]; dynein complex binding [GO:0070840]; identical protein binding [GO:0042802]; actin filament organization [GO:0007015]; chromosome localization to nuclear envelope involved in homologous chromosome segregation [GO:0090220]; double-strand break repair via homologous recombination [GO:0000724]; homologous chromosome pairing at meiosis [GO:0007129]; microtubule cytoskeleton organization involved in homologous chromosome segregation [GO:0090172]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]; spindle assembly [GO:0051225]; spindle localization [GO:0051653]; telomere localization [GO:0034397]	SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000250|UniProtKB:Q80VJ8, ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Nucleus {ECO:0000250|UniProtKB:Q80VJ8}. Chromosome, telomere {ECO:0000250|UniProtKB:Q80VJ8}. Note=Localized exclusively at telomeres from the leptotene to diplotene stages. Colocalizes with SUN2 at sites of telomere attachment in meiocytes. At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles. {ECO:0000250|UniProtKB:Q80VJ8}.
Q8N6L1	reviewed	KTAP2_HUMAN	Keratinocyte-associated protein 2 (KCP-2) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2) (Oligosaccharyl transferase subunit KCP2)	KRTCAP2 KCP2	Homo sapiens (Human)	136	FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:22467853). May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116). {ECO:0000269|PubMed:21768116, ECO:0000269|PubMed:22467853}.	MISCELLANEOUS: [Isoform 2]: Produced at low levels due to suboptimal Kozak context. {ECO:0000305}.	protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via arginine [GO:0042543]	oligosaccharyltransferase complex [GO:0008250]	enzyme activator activity [GO:0008047]	oligosaccharyltransferase complex [GO:0008250]; enzyme activator activity [GO:0008047]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via arginine [GO:0042543]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:21768116}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22266900}; Multi-pass membrane protein {ECO:0000269|PubMed:22266900}.
Q8N6M0	reviewed	OTU6B_HUMAN	Deubiquitinase OTUD6B (EC 3.4.19.12) (DUBA-5) (OTU domain-containing protein 6B)	OTUD6B DUBA5 CGI-77	Homo sapiens (Human)	293	FUNCTION: [Isoform 1]: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629). {ECO:0000269|PubMed:21267069, ECO:0000269|PubMed:27864334, ECO:0000269|PubMed:28343629}.; FUNCTION: [Isoform 2]: Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability. {ECO:0000269|PubMed:27864334}.		cell population proliferation [GO:0008283]; negative regulation of translation [GO:0017148]; positive regulation of translation [GO:0045727]; proteasome assembly [GO:0043248]; protein deubiquitination [GO:0016579]		cysteine-type deubiquitinase activity [GO:0004843]	cysteine-type deubiquitinase activity [GO:0004843]; cell population proliferation [GO:0008283]; negative regulation of translation [GO:0017148]; positive regulation of translation [GO:0045727]; proteasome assembly [GO:0043248]; protein deubiquitination [GO:0016579]	
Q8N6M3	reviewed	FITM2_HUMAN	Acyl-coenzyme A diphosphatase FITM2 (EC 3.6.1.-) (Fat storage-inducing transmembrane protein 2) (Fat-inducing protein 2)	FITM2 C20orf142 FIT2	Homo sapiens (Human)	262	FUNCTION: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (PubMed:32915949) (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen (PubMed:32915949) (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (PubMed:18160536, PubMed:32915949) (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987) (By similarity). {ECO:0000255|HAMAP-Rule:MF_03230, ECO:0000269|PubMed:18160536, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:32915949}.		cytoskeleton organization [GO:0007010]; fatty-acyl-CoA catabolic process [GO:0036115]; intracellular triglyceride homeostasis [GO:0035356]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; phospholipid biosynthetic process [GO:0008654]; positive regulation of sequestering of triglyceride [GO:0010890]; regulation of cell morphogenesis [GO:0022604]; regulation of triglyceride biosynthetic process [GO:0010866]; sequestering of triglyceride [GO:0030730]	endoplasmic reticulum membrane [GO:0005789]	acyl-coenzyme A diphosphatase activity [GO:0106399]; diacylglycerol binding [GO:0019992]; triglyceride binding [GO:0017129]	endoplasmic reticulum membrane [GO:0005789]; acyl-coenzyme A diphosphatase activity [GO:0106399]; diacylglycerol binding [GO:0019992]; triglyceride binding [GO:0017129]; cytoskeleton organization [GO:0007010]; fatty-acyl-CoA catabolic process [GO:0036115]; intracellular triglyceride homeostasis [GO:0035356]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; phospholipid biosynthetic process [GO:0008654]; positive regulation of sequestering of triglyceride [GO:0010890]; regulation of cell morphogenesis [GO:0022604]; regulation of triglyceride biosynthetic process [GO:0010866]; sequestering of triglyceride [GO:0030730]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03230, ECO:0000269|PubMed:18160536}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03230}.
Q8N6M6	reviewed	AMPO_HUMAN	Aminopeptidase O (AP-O) (EC 3.4.11.-)	AOPEP C9orf3 ONPEP	Homo sapiens (Human)	819	FUNCTION: Aminopeptidase which catalyzes the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. {ECO:0000250|UniProtKB:P15144}.		proteolysis [GO:0006508]	cytosol [GO:0005829]; nucleolus [GO:0005730]	metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleolus [GO:0005730]; metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8BXQ6}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000250|UniProtKB:Q8BXQ6}.
Q8N6P7	reviewed	I22R1_HUMAN	Interleukin-22 receptor subunit alpha-1 (IL-22 receptor subunit alpha-1) (IL-22R-alpha-1) (IL-22RA1) (Cytokine receptor class-II member 9) (Cytokine receptor family 2 member 9) (CRF2-9) (ZcytoR11)	IL22RA1 IL22R	Homo sapiens (Human)	574	FUNCTION: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {ECO:0000269|PubMed:11035029, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:12941841, ECO:0000269|PubMed:17204547}.	MISCELLANEOUS: Failure of medical and surgical therapy in Chronic rhinosinusitis with nasal polyps is associated with decreased expression of IL22RA1.	cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; negative regulation of inflammatory response [GO:0050728]	plasma membrane [GO:0005886]	cytokine receptor activity [GO:0004896]; interferon receptor activity [GO:0004904]; interleukin-20 binding [GO:0042015]; interleukin-22 receptor activity [GO:0042018]	plasma membrane [GO:0005886]; cytokine receptor activity [GO:0004896]; interferon receptor activity [GO:0004904]; interleukin-20 binding [GO:0042015]; interleukin-22 receptor activity [GO:0042018]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; negative regulation of inflammatory response [GO:0050728]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:12351624}; Single-pass type I membrane protein {ECO:0000255}.
Q8N6Q3	reviewed	CD177_HUMAN	CD177 antigen (Human neutrophil alloantigen 2a) (HNA-2a) (NB1 glycoprotein) (NB1 GP) (Polycythemia rubra vera protein 1) (PRV-1) (CD antigen CD177)	CD177 NB1 PRV1 UNQ595/PRO1181	Homo sapiens (Human)	437	FUNCTION: In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369). {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23202369, ECO:0000269|PubMed:23461681, ECO:0000269|PubMed:28807980}.	MISCELLANEOUS: [Isoform 2]: Associated with CD177-negative phenotype. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Associated with CD177-negative phenotype. {ECO:0000305}.	cell adhesion [GO:0007155]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell-cell junction maintenance [GO:0045217]; innate immune response [GO:0045087]; leukocyte cell-cell adhesion [GO:0007159]; neutrophil extravasation [GO:0072672]; neutrophil migration [GO:1990266]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of superoxide anion generation [GO:0032930]; protein localization to cell surface [GO:0034394]; regulation of endocytosis [GO:0030100]; regulation of integrin-mediated signaling pathway [GO:2001044]	extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; secretory granule membrane [GO:0030667]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	calcium-dependent protein binding [GO:0048306]; integrin binding [GO:0005178]; protease binding [GO:0002020]	extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; secretory granule membrane [GO:0030667]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; calcium-dependent protein binding [GO:0048306]; integrin binding [GO:0005178]; protease binding [GO:0002020]; cell adhesion [GO:0007155]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell-cell junction maintenance [GO:0045217]; innate immune response [GO:0045087]; leukocyte cell-cell adhesion [GO:0007159]; neutrophil extravasation [GO:0072672]; neutrophil migration [GO:1990266]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of superoxide anion generation [GO:0032930]; protein localization to cell surface [GO:0034394]; regulation of endocytosis [GO:0030100]; regulation of integrin-mediated signaling pathway [GO:2001044]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:12675722, ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:24926686, ECO:0000269|PubMed:27227454, ECO:0000269|PubMed:28240246, ECO:0000269|PubMed:28807980}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:17244676}. Membrane raft {ECO:0000269|PubMed:21193407}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:17244676}. Secreted {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:18462208}. Cytoplasmic granule membrane {ECO:0000269|PubMed:18462208}. Cell projection, lamellipodium {ECO:0000269|PubMed:28807980}. Note=Cell surface expression on neutrophils is increased upon TNF-alpha, fMLP or CXCL8/IL8-mediated stimulation (PubMed:17244676, PubMed:17580308). In neutrophils, stored predominantly in secondary and tertiary granules (PubMed:18462208). Can also be shedded from the cell membrane (PubMed:12239154, PubMed:18462208). Localizes to lamellar protrusions in spreading neutrophils (PubMed:28807980). {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:28807980}.
Q8N6R0	reviewed	EFNMT_HUMAN	eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)]	METTL13 EEF1AKNMT FEAT KIAA0859 CGI-01	Homo sapiens (Human)	699	FUNCTION: Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation (PubMed:30612740, PubMed:30143613). Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2' (PubMed:30143613). Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55' (PubMed:30612740, PubMed:30143613). Has no activity towards core histones H2A, H2B, H3 and H4 (PubMed:30612740). Negatively regulates cell proliferation at G1/S transition via transcriptional suppression of cell cycle regulatory genes such as CDK4 and CDK6 (PubMed:26763933). {ECO:0000269|PubMed:26763933, ECO:0000269|PubMed:30143613, ECO:0000269|PubMed:30612740}.	MISCELLANEOUS: Present in the circulating blood plasma of cancer patients, particularly in ovarian and non-small cell lung cancer patients, may potentially be used as a biomarker (PubMed:27659353). Acts as a tumor suppressor in bladder cancer suppressing cell migration and invasion (PubMed:26763933). Reduced expression is seen in later stages of the disease (PubMed:26763933). {ECO:0000269|PubMed:26763933, ECO:0000269|PubMed:27659353}.	methylation [GO:0032259]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of transcription by RNA polymerase II [GO:0000122]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-lysine N-methyltransferase activity [GO:0016279]; methylation [GO:0032259]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27659353}. Nucleus {ECO:0000269|PubMed:27659353}. Mitochondrion {ECO:0000269|PubMed:27659353}.
Q8N6R1	reviewed	SERP2_HUMAN	Stress-associated endoplasmic reticulum protein 2 (Ribosome-associated membrane protein RAMP4-2)	SERP2 C13orf21	Homo sapiens (Human)	65	FUNCTION: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential). {ECO:0000305}.		endoplasmic reticulum unfolded protein response [GO:0030968]; protein transport [GO:0015031]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum unfolded protein response [GO:0030968]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q8N6S4	reviewed	AN13C_HUMAN	Ankyrin repeat domain-containing protein 13C	ANKRD13C	Homo sapiens (Human)	541	FUNCTION: Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER. {ECO:0000269|PubMed:20959461}.		protein retention in ER lumen [GO:0006621]; regulation of anoikis [GO:2000209]; regulation of signaling receptor activity [GO:0010469]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]	signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; signaling receptor binding [GO:0005102]; protein retention in ER lumen [GO:0006621]; regulation of anoikis [GO:2000209]; regulation of signaling receptor activity [GO:0010469]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20959461}. Note=Associated with the cytosolic side.
Q8N6T3	reviewed	ARFG1_HUMAN	ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)	ARFGAP1 ARF1GAP	Homo sapiens (Human)	406	FUNCTION: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}.		protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; synapse [GO:0045202]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; synapse [GO:0045202]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Associates with the Golgi complex. {ECO:0000250}.
Q8N6T7	reviewed	SIR6_HUMAN	NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6)	SIRT6 SIR2L6	Homo sapiens (Human)	355	FUNCTION: NAD-dependent protein deacetylase, deacylase and mono-ADP-ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging (PubMed:18337721, PubMed:19135889, PubMed:19625767, PubMed:21680843, PubMed:23217706, PubMed:23653361, PubMed:24052263, PubMed:27322069, PubMed:27180906, PubMed:21362626, PubMed:23552949, PubMed:30374165, PubMed:29555651). Displays protein-lysine deacetylase or defatty-acylase (demyristoylase and depalmitoylase) activity, depending on the context (PubMed:24052263, PubMed:27322069, PubMed:23552949). Acts as a key histone deacetylase by catalyzing deacetylation of histone H3 at 'Lys-9', 'Lys-18' and 'Lys-56' (H3K9ac, H3K18ac and H3K56ac, respectively), suppressing target gene expression of several transcription factors, including NF-kappa-B (PubMed:19625767, PubMed:24012758, PubMed:23892288, PubMed:23911928, PubMed:27043296, PubMed:26898756, PubMed:27180906, PubMed:33067423, PubMed:21362626, PubMed:30374165, PubMed:26456828). Acts as an inhibitor of transcription elongation by mediating deacetylation of H3K9ac and H3K56ac, preventing release of NELFE from chromatin and causing transcriptional pausing (By similarity). Involved in DNA repair by promoting double-strand break (DSB) repair: acts as a DSB sensor by recognizing and binding DSB sites, leading to (1) recruitment of DNA repair proteins, such as SMARCA5/SNF2H, and (2) deacetylation of histone H3K9ac and H3K56ac (PubMed:23911928, PubMed:31995034, PubMed:32538779). SIRT6 participation to DSB repair is probably involved in extension of life span (By similarity). Also promotes DNA repair by deacetylating non-histone proteins, such as DDB2 and p53/TP53 (PubMed:32789493, PubMed:29474172). Specifically deacetylates H3K18ac at pericentric heterochromatin, thereby maintaining pericentric heterochromatin silencing at centromeres and protecting against genomic instability and cellular senescence (PubMed:27043296). Involved in telomere maintenance by catalyzing deacetylation of histone H3 in telomeric chromatin, regulating telomere position effect and telomere movement in response to DNA damage (PubMed:18337721, PubMed:19625767, PubMed:21847107). Required for embryonic stem cell differentiation by mediating histone deacetylation of H3K9ac (PubMed:25915124, PubMed:29555651). Plays a major role in metabolism by regulating processes such as glycolysis, gluconeogenesis, insulin secretion and lipid metabolism (PubMed:24012758, PubMed:26787900). Inhibits glycolysis via histone deacetylase activity and by acting as a corepressor of the transcription factor HIF1A, thereby controlling the expression of multiple glycolytic genes (By similarity). Has tumor suppressor activity by repressing glycolysis, thereby inhibiting the Warburg effect (PubMed:23217706). Also regulates glycolysis and tumorigenesis by mediating deacetylation and nuclear export of non-histone proteins, such as isoform M2 of PKM (PKM2) (PubMed:26787900). Acts as a negative regulator of gluconeogenesis by mediating deacetylation of non-histone proteins, such as FOXO1 and KAT2A/GCN5 (PubMed:23142079, PubMed:25009184). Promotes beta-oxidation of fatty acids during fasting by catalyzing deacetylation of NCOA2, inducing coactivation of PPARA (By similarity). Acts as a regulator of lipid catabolism in brown adipocytes, both by catalyzing deacetylation of histones and non-histone proteins, such as FOXO1 (By similarity). Also acts as a regulator of circadian rhythms, both by regulating expression of clock-controlled genes involved in lipid and carbohydrate metabolism, and by catalyzing deacetylation of PER2 (By similarity). The defatty-acylase activity is specifically involved in regulation of protein secretion (PubMed:24052263, PubMed:23552949, PubMed:27322069, PubMed:28406396). Has high activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as RRAS2 and TNF, thereby regulating their secretion (PubMed:23552949, PubMed:28406396). Also acts as a mono-ADP-ribosyltransferase by mediating mono-ADP-ribosylation of PARP1, TRIM28/KAP1 or SMARCC2/BAF170 (PubMed:21680843, PubMed:22753495, PubMed:27568560, PubMed:27322069). Mono-ADP-ribosyltransferase activity is involved in DNA repair, cellular senescence, repression of LINE-1 retrotransposon elements and regulation of transcription (PubMed:21680843, PubMed:22753495, PubMed:27568560). {ECO:0000250|UniProtKB:P59941, ECO:0000269|PubMed:18337721, ECO:0000269|PubMed:19135889, ECO:0000269|PubMed:19625767, ECO:0000269|PubMed:21362626, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:21847107, ECO:0000269|PubMed:22753495, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:23217706, ECO:0000269|PubMed:23552949, ECO:0000269|PubMed:23653361, ECO:0000269|PubMed:23892288, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:24012758, ECO:0000269|PubMed:24052263, ECO:0000269|PubMed:25009184, ECO:0000269|PubMed:25915124, ECO:0000269|PubMed:26456828, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:26898756, ECO:0000269|PubMed:27043296, ECO:0000269|PubMed:27180906, ECO:0000269|PubMed:27322069, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:28406396, ECO:0000269|PubMed:29474172, ECO:0000269|PubMed:29555651, ECO:0000269|PubMed:30374165, ECO:0000269|PubMed:31995034, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:32789493, ECO:0000269|PubMed:33067423}.		base-excision repair [GO:0006284]; cardiac muscle cell differentiation [GO:0055007]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; determination of adult lifespan [GO:0008340]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; glucose homeostasis [GO:0042593]; ketone biosynthetic process [GO:0042181]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular senescence [GO:2000773]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of glucose import [GO:0046325]; negative regulation of glycolytic process [GO:0045820]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; pericentric heterochromatin formation [GO:0031508]; positive regulation of blood vessel branching [GO:1905555]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of insulin secretion [GO:0032024]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein localization to chromatin [GO:0120187]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein deacetylation [GO:0006476]; protein delipidation [GO:0051697]; protein destabilization [GO:0031648]; protein localization to site of double-strand break [GO:1990166]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of lipid catabolic process [GO:0050994]; regulation of lipid metabolic process [GO:0019216]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein secretion [GO:0050708]; response to UV [GO:0009411]; retrotransposon silencing [GO:0010526]; subtelomeric heterochromatin formation [GO:0031509]	chromatin [GO:0000785]; chromosome, subtelomeric region [GO:0099115]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]	chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA damage sensor activity [GO:0140612]; lncRNA binding [GO:0106222]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD+- protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; NAD-dependent histone deacetylase activity [GO:0017136]; NAD-dependent histone H3K18 deacetylase activity [GO:0097372]; NAD-dependent histone H3K56 deacetylase activity [GO:0140765]; NAD-dependent histone H3K9 deacetylase activity [GO:0046969]; NAD-dependent protein deacetylase activity [GO:0034979]; NAD-dependent protein demyristoylase activity [GO:0140773]; NAD-dependent protein depalmitoylase activity [GO:0140774]; nucleosome binding [GO:0031491]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; TORC2 complex binding [GO:1904841]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome, subtelomeric region [GO:0099115]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA damage sensor activity [GO:0140612]; lncRNA binding [GO:0106222]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD+- protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; NAD-dependent histone deacetylase activity [GO:0017136]; NAD-dependent histone H3K18 deacetylase activity [GO:0097372]; NAD-dependent histone H3K56 deacetylase activity [GO:0140765]; NAD-dependent histone H3K9 deacetylase activity [GO:0046969]; NAD-dependent protein deacetylase activity [GO:0034979]; NAD-dependent protein demyristoylase activity [GO:0140773]; NAD-dependent protein depalmitoylase activity [GO:0140774]; nucleosome binding [GO:0031491]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; TORC2 complex binding [GO:1904841]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]; base-excision repair [GO:0006284]; cardiac muscle cell differentiation [GO:0055007]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; determination of adult lifespan [GO:0008340]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; glucose homeostasis [GO:0042593]; ketone biosynthetic process [GO:0042181]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular senescence [GO:2000773]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of glucose import [GO:0046325]; negative regulation of glycolytic process [GO:0045820]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; pericentric heterochromatin formation [GO:0031508]; positive regulation of blood vessel branching [GO:1905555]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of insulin secretion [GO:0032024]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein localization to chromatin [GO:0120187]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein deacetylation [GO:0006476]; protein delipidation [GO:0051697]; protein destabilization [GO:0031648]; protein localization to site of double-strand break [GO:1990166]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of lipid catabolic process [GO:0050994]; regulation of lipid metabolic process [GO:0019216]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein secretion [GO:0050708]; response to UV [GO:0009411]; retrotransposon silencing [GO:0010526]; subtelomeric heterochromatin formation [GO:0031509]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18337721, ECO:0000269|PubMed:19135889, ECO:0000269|PubMed:26456828, ECO:0000269|PubMed:26898756, ECO:0000269|PubMed:29555651}. Chromosome {ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:26456828, ECO:0000269|PubMed:27043296, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:27912097, ECO:0000269|PubMed:31995034, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:32789493}. Chromosome, telomere {ECO:0000269|PubMed:18337721}. Endoplasmic reticulum {ECO:0000269|PubMed:23552949}. Note=Predominantly nuclear (PubMed:18337721). Associated with pericentric heterochromatin and telomeric heterochromatin regions (PubMed:18337721, PubMed:27043296). Localizes to DNA damage sites: directly recognizes and binds double-strand breaks (DSBs) sites via a tunnel-like structure that has high affinity for DSBs (PubMed:21680843, PubMed:23911928, PubMed:27568560, PubMed:31995034, PubMed:32538779). A fraction localizes to the endoplasmic reticulum (PubMed:23552949). {ECO:0000269|PubMed:18337721, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:23552949, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:27043296, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:31995034, ECO:0000269|PubMed:32538779}.
Q8N6U8	reviewed	GP161_HUMAN	G-protein coupled receptor 161 (G-protein coupled receptor RE2)	GPR161	Homo sapiens (Human)	529	FUNCTION: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). {ECO:0000250}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; endocytic vesicle membrane [GO:0030666]; glial cell projection [GO:0097386]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	G protein-coupled receptor activity [GO:0004930]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; endocytic vesicle membrane [GO:0030666]; glial cell projection [GO:0097386]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). {ECO:0000250}.
Q8N6W0	reviewed	CELF5_HUMAN	CUGBP Elav-like family member 5 (CELF-5) (Bruno-like protein 5) (CUG-BP- and ETR-3-like factor 5) (RNA-binding protein BRUNOL-5)	CELF5 BRUNOL5	Homo sapiens (Human)	485	FUNCTION: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269|PubMed:11158314}.		mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q8N6Y0	reviewed	USBP1_HUMAN	Harmonin-binding protein USHBP1 (AIE-75-binding protein) (Mutated in colon cancer protein 2) (MCC-2) (Usher syndrome type-1C protein-binding protein 1) (USH1C-binding protein 1)	USHBP1 AIEBP MCC2	Homo sapiens (Human)	703		MISCELLANEOUS: [Isoform 2]: Due to the retention of an intron in the cDNA leading to a prematurate stop codon. {ECO:0000269|PubMed:11311560}.			PDZ domain binding [GO:0030165]	PDZ domain binding [GO:0030165]	
Q8N715	reviewed	CC185_HUMAN	Coiled-coil domain-containing protein 185	CCDC185 C1orf65	Homo sapiens (Human)	623							
Q8N720	reviewed	ZN655_HUMAN	Zinc finger protein 655 (Vav-interacting Krueppel-like protein)	ZNF655 VIK	Homo sapiens (Human)	491	FUNCTION: May be involved in transcriptional regulation.		negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N726	reviewed	ARF_HUMAN	Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF)	CDKN2A CDKN2 MLM	Homo sapiens (Human)	132	FUNCTION: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (By similarity). Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. {ECO:0000250|UniProtKB:Q64364, ECO:0000269|PubMed:11314011, ECO:0000269|PubMed:11314038, ECO:0000269|PubMed:12660818, ECO:0000269|PubMed:14636574, ECO:0000269|PubMed:15361825, ECO:0000269|PubMed:15567177, ECO:0000269|PubMed:15876874, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:16713577, ECO:0000269|PubMed:18305112, ECO:0000269|PubMed:22094112, ECO:0000269|PubMed:9724636}.; FUNCTION: [Isoform smARF]: May be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP. {ECO:0000269|PubMed:16713577}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; amyloid fibril formation [GO:1990000]; apoptotic mitochondrial changes [GO:0008637]; autophagy of mitochondrion [GO:0000422]; cell cycle [GO:0007049]; cellular senescence [GO:0090398]; mitochondrial depolarization [GO:0051882]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein neddylation [GO:2000435]; negative regulation of proteolysis involved in protein catabolic process [GO:1903051]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; nuclear body organization [GO:0030575]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein destabilization [GO:0031648]; protein K63-linked ubiquitination [GO:0070534]; protein localization to nucleolus [GO:1902570]; protein localization to nucleus [GO:0034504]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; regulation of apoptotic DNA fragmentation [GO:1902510]; regulation of cell cycle [GO:0051726]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of protein export from nucleus [GO:0046825]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; rRNA processing [GO:0006364]; somatic stem cell division [GO:0048103]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SUMO transferase activity [GO:0019789]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin-protein transferase inhibitor activity [GO:0055105]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SUMO transferase activity [GO:0019789]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin-protein transferase inhibitor activity [GO:0055105]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; amyloid fibril formation [GO:1990000]; apoptotic mitochondrial changes [GO:0008637]; autophagy of mitochondrion [GO:0000422]; cell cycle [GO:0007049]; cellular senescence [GO:0090398]; mitochondrial depolarization [GO:0051882]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein neddylation [GO:2000435]; negative regulation of proteolysis involved in protein catabolic process [GO:1903051]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; nuclear body organization [GO:0030575]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein destabilization [GO:0031648]; protein K63-linked ubiquitination [GO:0070534]; protein localization to nucleolus [GO:1902570]; protein localization to nucleus [GO:0034504]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; regulation of apoptotic DNA fragmentation [GO:1902510]; regulation of cell cycle [GO:0051726]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of protein export from nucleus [GO:0046825]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; rRNA processing [GO:0006364]; somatic stem cell division [GO:0048103]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16173922, ECO:0000269|PubMed:18305112, ECO:0000269|PubMed:22094112, ECO:0000269|PubMed:27323397}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18305112, ECO:0000269|PubMed:27323397}.; SUBCELLULAR LOCATION: [Isoform smARF]: Mitochondrion {ECO:0000269|PubMed:16713577}.
Q8N743	reviewed	KI3L3_HUMAN	Killer cell immunoglobulin-like receptor 3DL3 (CD158 antigen-like family member Z) (Killer cell inhibitory receptor 1) (CD antigen CD158z)	KIR3DL3 CD158Z KIR3DL7 KIRC1	Homo sapiens (Human)	410	FUNCTION: Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis. {ECO:0000303|PubMed:11513144}.			plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q8N752	reviewed	KC1AL_HUMAN	Casein kinase I isoform alpha-like (CKI-alpha-like) (EC 2.7.11.1) (CK1)	CSNK1A1L	Homo sapiens (Human)	337	FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). {ECO:0000250}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]; phosphorylation [GO:0016310]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; phosphorylation [GO:0016310]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8N766	reviewed	EMC1_HUMAN	ER membrane protein complex subunit 1	EMC1 KIAA0090 PSEC0263	Homo sapiens (Human)	993	FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305}.		protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; protein-containing complex [GO:0032991]		EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Single-pass type I membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}.
Q8N7B6	reviewed	PACRL_HUMAN	PACRG-like protein	PACRGL C4orf28	Homo sapiens (Human)	248							
Q8N7C0	reviewed	LRC52_HUMAN	Leucine-rich repeat-containing protein 52 (BK channel auxiliary gamma subunit LRRC52)	LRRC52	Homo sapiens (Human)	313	FUNCTION: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties. {ECO:0000269|PubMed:22547800, ECO:0000269|PubMed:23129643}.		establishment of localization in cell [GO:0051649]; positive regulation of voltage-gated potassium channel activity [GO:1903818]; potassium ion transmembrane transport [GO:0071805]; reproductive process [GO:0022414]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	potassium channel activator activity [GO:0099104]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; potassium channel activator activity [GO:0099104]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; establishment of localization in cell [GO:0051649]; positive regulation of voltage-gated potassium channel activity [GO:1903818]; potassium ion transmembrane transport [GO:0071805]; reproductive process [GO:0022414]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Expression at the cell surface may require the presence of KCNU1.
Q8N7C3	reviewed	TRIMM_HUMAN	Probable E3 ubiquitin-protein ligase TRIML2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIML2) (SPRY domain-containing protein 6) (Tripartite motif family-like protein 2)	TRIML2 SPRYD6	Homo sapiens (Human)	437			innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; response to retinoic acid [GO:0032526]	cytoplasm [GO:0005737]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; response to retinoic acid [GO:0032526]	
Q8N7E2	reviewed	CBLL2_HUMAN	E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2)	CBLL2 ZNF645	Homo sapiens (Human)	425	FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:20657603). May operate on tyrosine-phosphorylated SRC substrates (PubMed:22252131). {ECO:0000269|PubMed:20657603, ECO:0000269|PubMed:22252131}.		protein ubiquitination [GO:0016567]; regulation of cell adhesion [GO:0030155]	cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]; regulation of cell adhesion [GO:0030155]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20657603}. Note=Localized over the postacrosomal perinuclear theca region and the entire length of sperm tail. {ECO:0000269|PubMed:20657603}.
Q8N7H5	reviewed	PAF1_HUMAN	RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2)	PAF1 PD2	Homo sapiens (Human)	531	FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro. {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:19410543, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879, ECO:0000269|PubMed:22419161}.		cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; mRNA polyadenylation [GO:0006378]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055]	Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993]	Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993]; cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; mRNA polyadenylation [GO:0006378]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:30367041}. Note=Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin.
Q8N7J2	reviewed	AMER2_HUMAN	APC membrane recruitment protein 2 (Amer2) (Protein FAM123A)	AMER2 FAM123A	Homo sapiens (Human)	671	FUNCTION: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. {ECO:0000269|PubMed:22128170}.		ectoderm development [GO:0007398]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055]	plasma membrane [GO:0005886]	beta-catenin binding [GO:0008013]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; ectoderm development [GO:0007398]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22128170}; Peripheral membrane protein {ECO:0000269|PubMed:22128170}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Q8N7U6	reviewed	EFHB_HUMAN	EF-hand domain-containing family member B (Cilia- and flagella-associated protein 21)	EFHB CFAP21	Homo sapiens (Human)	833	FUNCTION: Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus (PubMed:30481768). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). {ECO:0000269|PubMed:30481768, ECO:0000269|PubMed:36191189}.		calcium ion transport [GO:0006816]; negative regulation of protein binding [GO:0032091]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of store-operated calcium entry [GO:2001256]	axonemal microtubule [GO:0005879]	calcium ion sensor activity [GO:0061891]	axonemal microtubule [GO:0005879]; calcium ion sensor activity [GO:0061891]; calcium ion transport [GO:0006816]; negative regulation of protein binding [GO:0032091]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of store-operated calcium entry [GO:2001256]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:30481768}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q8N7U7	reviewed	TPRX1_HUMAN	Tetra-peptide repeat homeobox protein 1	TPRX1	Homo sapiens (Human)	411	FUNCTION: Transcription factor expressed after fertilization required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:35314832, PubMed:36074823). Binds and activates expression of key ZGA marker genes, such as NANOGNB, ZSCAN4, DUXB, KLF5 and DPPA3 (PubMed:36074823). Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif (PubMed:36074823). {ECO:0000269|PubMed:35314832, ECO:0000269|PubMed:36074823}.		maternal-to-zygotic transition of gene expression [GO:0160021]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; maternal-to-zygotic transition of gene expression [GO:0160021]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q8N7W2	reviewed	BEND7_HUMAN	BEN domain-containing protein 7	BEND7 C10orf30	Homo sapiens (Human)	519				extracellular exosome [GO:0070062]	DNA binding [GO:0003677]	extracellular exosome [GO:0070062]; DNA binding [GO:0003677]	
Q8N7X4	reviewed	MAGB6_HUMAN	Melanoma-associated antigen B6 (Cancer/testis antigen 3.4) (CT3.4) (MAGE-B6 antigen)	MAGEB6	Homo sapiens (Human)	407			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
Q8N807	reviewed	PDILT_HUMAN	Protein disulfide-isomerase-like protein of the testis	PDILT	Homo sapiens (Human)	584	FUNCTION: Probable redox-inactive chaperone involved in spermatogenesis. {ECO:0000269|PubMed:17507649}.		germ cell migration [GO:0008354]; protein folding [GO:0006457]; spermatid development [GO:0007286]	endoplasmic reticulum [GO:0005783]	protein disulfide isomerase activity [GO:0003756]	endoplasmic reticulum [GO:0005783]; protein disulfide isomerase activity [GO:0003756]; germ cell migration [GO:0008354]; protein folding [GO:0006457]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:15475357}.
Q8N841	reviewed	TTLL6_HUMAN	Tubulin polyglutamylase TTLL6 (EC 6.3.2.-) (Protein polyglutamylase TTLL6) (Tubulin--tyrosine ligase-like protein 6)	TTLL6 TTL.6	Homo sapiens (Human)	843	FUNCTION: Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins. Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail. Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions. Mediates microtubule polyglutamylation in primary cilia axoneme, which is important for ciliary structural formation and motility. Mediates microtubule polyglutamylation in motile cilia, necessary for the regulation of ciliary coordinated beating. Polyglutamylates non-tubulin protein nucleotidyltransferase CGAS, leading to CGAS DNA-binding inhibition, thereby preventing antiviral defense response. {ECO:0000250|UniProtKB:A4Q9E8}.		microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule severing [GO:0051013]; positive regulation of cilium movement [GO:0003353]; protein polyglutamylation [GO:0018095]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]	9+0 non-motile cilium [GO:0097731]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity [GO:0070739]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	9+0 non-motile cilium [GO:0097731]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity [GO:0070739]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule severing [GO:0051013]; positive regulation of cilium movement [GO:0003353]; protein polyglutamylation [GO:0018095]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A4Q9E8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A4Q9E8}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:22246503}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22246503}. Note=CEP41 is required for its transport between the basal body and the cilium axoneme. {ECO:0000269|PubMed:22246503}.
Q8N865	reviewed	SMIP4_HUMAN	Sperm-associated microtubule inner protein 4	SPMIP4 C7orf31	Homo sapiens (Human)	590	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella. {ECO:0000250|UniProtKB:E1B9R1}.			centrosome [GO:0005813]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25074808}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000305}. Note=Localizes to the A-tubules of DMTs. {ECO:0000250|UniProtKB:E1B9R1}.
Q8N884	reviewed	CGAS_HUMAN	Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1)	CGAS C6orf150 MB21D1	Homo sapiens (Human)	522	FUNCTION: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:23258413, PubMed:24077100, PubMed:25131990, PubMed:23707061, PubMed:23722159, PubMed:29976794, PubMed:30799039, PubMed:21478870, PubMed:23707065, PubMed:24116191, PubMed:24462292, PubMed:32814054, PubMed:33273464, PubMed:26300263, PubMed:33542149, PubMed:31142647, PubMed:37217469). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:33230297, PubMed:32817552, PubMed:33606975, PubMed:35438208, PubMed:35460603, PubMed:35322803, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:31299200, PubMed:28738408, PubMed:28759889, PubMed:33230297, PubMed:33031745). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:31299200, PubMed:28738408, PubMed:28759889, PubMed:33230297, PubMed:33031745, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:33542149, PubMed:33051594, PubMed:32911482, PubMed:32912999). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:37217469}.	MISCELLANEOUS: The cGAS-STING signaling pathway drives sterile inflammation leading to type I interferon immunopathology in severe COVID-19 disease caused by SARS-CoV-2 virus infection (PubMed:35045565). Tissue damages in the lung and skin lesions are caused by activation of the cGAS-STING signaling leading to aberrant inflammation (PubMed:35045565). Endothelial cell damage is also caused by activation of the cGAS-STING pathway: SARS-CoV-2 infection triggers mitochondrial DNA release into the cytosol (PubMed:35045565). Released mitochondrial DNA is then detected by CGAS, leading to activation of the cGAS-STING pathway, triggering type-I interferon production and autoinflammation (PubMed:35045565). {ECO:0000269|PubMed:35045565}.	activation of innate immune response [GO:0002218]; cAMP-mediated signaling [GO:0019933]; cellular response to exogenous dsRNA [GO:0071360]; cGMP-mediated signaling [GO:0019934]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of innate immune response [GO:0045824]; paracrine signaling [GO:0038001]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cellular senescence [GO:2000774]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type I interferon production [GO:0032481]; regulation of immunoglobulin production [GO:0002637]; regulation of innate immune response [GO:0045088]; regulation of T cell activation [GO:0050863]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]	2',3'-cyclic GMP-AMP synthase activity [GO:0061501]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; nucleosome binding [GO:0031491]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; 2',3'-cyclic GMP-AMP synthase activity [GO:0061501]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; nucleosome binding [GO:0031491]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]; protein homodimerization activity [GO:0042803]; activation of innate immune response [GO:0002218]; cAMP-mediated signaling [GO:0019933]; cellular response to exogenous dsRNA [GO:0071360]; cGMP-mediated signaling [GO:0019934]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of innate immune response [GO:0045824]; paracrine signaling [GO:0038001]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cellular senescence [GO:2000774]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type I interferon production [GO:0032481]; regulation of immunoglobulin production [GO:0002637]; regulation of innate immune response [GO:0045088]; regulation of T cell activation [GO:0050863]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29263269, ECO:0000269|PubMed:29937271, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30811988, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:31808743, ECO:0000269|PubMed:32792394, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33406424, ECO:0000269|PubMed:33476576, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35438208}. Chromosome {ECO:0000269|PubMed:30811988, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33051594}. Cell membrane {ECO:0000269|PubMed:30827685, ECO:0000269|PubMed:32351706}; Peripheral membrane protein {ECO:0000269|PubMed:30827685}. Cytoplasm, cytosol {ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:29263269, ECO:0000269|PubMed:29937271, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:30827685, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:31808743, ECO:0000269|PubMed:32792394, ECO:0000269|PubMed:33406424, ECO:0000269|PubMed:33476576, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:37217469}. Note=Mainly localizes in the nucleus, and at low level in the cytosol (PubMed:31808743, PubMed:31544964). On chromosomes, enriched on centromeric satellite and LINE DNA repeat elements (PubMed:30811988). Exported from the nucleus to the cytosol in a XPO1/CRM1 via the nuclear export signal in response to DNA stimulation (PubMed:33406424). Outside the nucleus, localizes at the cell membrane as a peripheral membrane protein in resting conditions: association to the cell membrane is mediated via binding to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:30827685). Localization at the cell membrane is required to limit the recognition of self-DNA (PubMed:30827685). Following detection of double-stranded DNA (dsDNA), released from the cell membrane into the cytosol in order to signal (PubMed:30827685). Upon transfection with dsDNA forms punctate structures that co-localize with DNA and Beclin-1 (BECN1) (PubMed:26048138). Phosphorylation at Tyr-215 promotes cytosolic retention (PubMed:30356214). In response to translation stress, translocates to the cytosol and associates with collided ribosomes (PubMed:34111399). {ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30811988, ECO:0000269|PubMed:30827685, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:31808743, ECO:0000269|PubMed:33406424, ECO:0000269|PubMed:34111399}.; SUBCELLULAR LOCATION: Note=(Microbial infection) Upon infection with virulent M.tuberculosis forms aggregates with dsDNA, non-virulent bacteria (without the ESX-1 locus) do not form these aggregates (PubMed:26048138). {ECO:0000269|PubMed:26048138}.
Q8N895	reviewed	ZN366_HUMAN	Zinc finger protein 366 (Dendritic cell-specific transcript protein) (DC-SCRIPT)	ZNF366	Homo sapiens (Human)	744	FUNCTION: Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases. {ECO:0000269|PubMed:17085477}.		negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; response to estrogen [GO:0043627]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor activity [GO:0003714]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; response to estrogen [GO:0043627]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16393996, ECO:0000269|PubMed:17085477}.
Q8N8B7	reviewed	TEANC_HUMAN	Transcription elongation factor A N-terminal and central domain-containing protein (TFIIS central domain-containing protein 1)	TCEANC	Homo sapiens (Human)	351			DNA-templated transcription [GO:0006351]	nucleus [GO:0005634]		nucleus [GO:0005634]; DNA-templated transcription [GO:0006351]	
Q8N8E2	reviewed	ZN513_HUMAN	Zinc finger protein 513	ZNF513	Homo sapiens (Human)	541	FUNCTION: Transcriptional regulator that plays a role in retinal development and maintenance. {ECO:0000269|PubMed:20797688}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; response to stimulus [GO:0050896]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to stimulus [GO:0050896]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20797688}.
Q8N8N0	reviewed	RN152_HUMAN	E3 ubiquitin-protein ligase RNF152 (EC 2.3.2.27) (RING finger protein 152) (RING-type E3 ubiquitin transferase RNF152)	RNF152	Homo sapiens (Human)	203	FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB (PubMed:25936802, PubMed:30514904). Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling (PubMed:25936802). Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition (PubMed:30514904). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation (PubMed:21203937). Induces apoptosis when overexpressed (PubMed:21203937). {ECO:0000269|PubMed:21203937, ECO:0000269|PubMed:25936802, ECO:0000269|PubMed:30514904}.		apoptotic process [GO:0006915]; cellular response to amino acid starvation [GO:0034198]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]	lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; organelle membrane [GO:0031090]	metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; organelle membrane [GO:0031090]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; cellular response to amino acid starvation [GO:0034198]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:25936802, ECO:0000305|PubMed:21203937}; Single-pass membrane protein {ECO:0000269|PubMed:25936802, ECO:0000305|PubMed:21203937}.
Q8N8N7	reviewed	PTGR2_HUMAN	Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) (Zinc-binding alcohol dehydrogenase domain-containing protein 1)	PTGR2 ZADH1	Homo sapiens (Human)	351	FUNCTION: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VDQ1, ECO:0000269|PubMed:19000823}.		prostaglandin metabolic process [GO:0006693]	cytoplasm [GO:0005737]	13-prostaglandin reductase activity [GO:0036132]; 15-oxoprostaglandin 13-oxidase activity [GO:0047522]	cytoplasm [GO:0005737]; 13-prostaglandin reductase activity [GO:0036132]; 15-oxoprostaglandin 13-oxidase activity [GO:0047522]; prostaglandin metabolic process [GO:0006693]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8N8Q1	reviewed	C56D1_HUMAN	Probable transmembrane reductase CYB561D1 (EC 7.2.1.3) (Cytochrome b561 domain-containing protein 1)	CYB561D1	Homo sapiens (Human)	229	FUNCTION: Probable transmembrane reductase that may use ascorbate as an electron donor and transfer electrons across membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in another cellular compartment. {ECO:0000305}.			membrane [GO:0016020]	heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; transmembrane ascorbate ferrireductase activity [GO:0140571]; transmembrane monodehydroascorbate reductase activity [GO:0140575]	membrane [GO:0016020]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; transmembrane ascorbate ferrireductase activity [GO:0140571]; transmembrane monodehydroascorbate reductase activity [GO:0140575]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N8Q3	reviewed	ENDOV_HUMAN	Endonuclease V (hEndoV) (EC 3.1.26.-) (Inosine-specific endoribonuclease)	ENDOV	Homo sapiens (Human)	282	FUNCTION: [Isoform 1]: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:23912683, PubMed:23912718, PubMed:27573237, PubMed:31703097, PubMed:25195743). Active against both single-stranded and double-stranded RNAs (PubMed:31703097, PubMed:25195743). Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs) (PubMed:23912718). Cleaves mRNAs and tRNAs containing inosine (PubMed:23912683, PubMed:31703097). Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3' (PubMed:23912718, PubMed:27573237). Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing (Probable). Binds branched DNA structures (PubMed:23139746). {ECO:0000269|PubMed:23139746, ECO:0000269|PubMed:23912683, ECO:0000269|PubMed:23912718, ECO:0000269|PubMed:25195743, ECO:0000269|PubMed:27573237, ECO:0000269|PubMed:31703097, ECO:0000305}.; FUNCTION: [Isoform 6]: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:31703097). Cleaves tRNAs containing inosine (PubMed:31703097). {ECO:0000269|PubMed:31703097}.; FUNCTION: [Isoform 7]: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:31703097). Cleaves tRNAs containing inosine (PubMed:31703097). {ECO:0000269|PubMed:31703097}.		DNA repair [GO:0006281]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleolus [GO:0005730]	DNA binding [GO:0003677]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; magnesium ion binding [GO:0000287]; RNA endonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; single-stranded RNA binding [GO:0003727]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleolus [GO:0005730]; DNA binding [GO:0003677]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; magnesium ion binding [GO:0000287]; RNA endonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; single-stranded RNA binding [GO:0003727]; DNA repair [GO:0006281]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:23912718, ECO:0000269|PubMed:31703097}. Nucleus, nucleolus {ECO:0000269|PubMed:23139746, ECO:0000269|PubMed:31703097}. Cytoplasm, Stress granule {ECO:0000269|PubMed:27573237}. Note=Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with PABPC1. {ECO:0000269|PubMed:27573237}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000269|PubMed:31703097}. Nucleus, nucleolus {ECO:0000269|PubMed:31703097}. Cytoplasm, Stress granule {ECO:0000269|PubMed:31703097}. Note=Relocalizes to cytoplasmic stress granules upon cellular stress. {ECO:0000269|PubMed:31703097}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm {ECO:0000269|PubMed:31703097}. Nucleus, nucleolus {ECO:0000269|PubMed:31703097}. Cytoplasm, Stress granule {ECO:0000269|PubMed:31703097}. Note=Relocalizes to cytoplasmic stress granules upon cellular stress. {ECO:0000269|PubMed:31703097}.
Q8N8Q8	reviewed	COX18_HUMAN	Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18Hs) (Cytochrome c oxidase assembly protein 18)	COX18 OXA1L2	Homo sapiens (Human)	333	FUNCTION: Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). {ECO:0000269|PubMed:16911509, ECO:0000269|PubMed:28330871}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein insertion into mitochondrial membrane [GO:0051204]; respiratory chain complex IV assembly [GO:0008535]	mitochondrial inner membrane [GO:0005743]	membrane insertase activity [GO:0032977]	mitochondrial inner membrane [GO:0005743]; membrane insertase activity [GO:0032977]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein insertion into mitochondrial membrane [GO:0051204]; respiratory chain complex IV assembly [GO:0008535]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16212937, ECO:0000269|PubMed:28330871}; Multi-pass membrane protein {ECO:0000269|PubMed:16212937}.
Q8N8R3	reviewed	S2529_HUMAN	Mitochondrial basic amino acids transporter (Carnitine/acylcarnitine translocase-like) (CACT-like) (Mitochondrial carnitine/acylcarnitine carrier protein CACL) (Mitochondrial ornithine transporter 3) (Solute carrier family 25 member 29)	SLC25A29 C14orf69 ORNT3	Homo sapiens (Human)	303	FUNCTION: Mitochondrial transporter of arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine (PubMed:19287344, PubMed:24652292). Does not transport carnitine nor acylcarnitines (PubMed:24652292). Functions by both counter-exchange and uniport mechanisms (PubMed:24652292). Plays a physiolocical role in the import of basic amino acids into mitochondria for mitochondrial protein synthesis and amino acid degradation (PubMed:19287344, PubMed:24652292). {ECO:0000269|PubMed:19287344, ECO:0000269|PubMed:24652292}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	acyl carnitine transport [GO:0006844]; amino acid transport [GO:0006865]; L-arginine transmembrane transport [GO:1903826]; L-histidine transmembrane transport [GO:0089709]; L-lysine transmembrane transport [GO:1903401]; mitochondrial L-ornithine transmembrane transport [GO:1990575]; ornithine transport [GO:0015822]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	basic amino acid transmembrane transporter activity [GO:0015174]; high-affinity L-arginine transmembrane transporter activity [GO:0005289]; high-affinity lysine transmembrane transporter activity [GO:0005292]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; basic amino acid transmembrane transporter activity [GO:0015174]; high-affinity L-arginine transmembrane transporter activity [GO:0005289]; high-affinity lysine transmembrane transporter activity [GO:0005292]; acyl carnitine transport [GO:0006844]; amino acid transport [GO:0006865]; L-arginine transmembrane transport [GO:1903826]; L-histidine transmembrane transport [GO:0089709]; L-lysine transmembrane transport [GO:1903401]; mitochondrial L-ornithine transmembrane transport [GO:1990575]; ornithine transport [GO:0015822]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:19287344}; Multi-pass membrane protein {ECO:0000255}.
Q8N8R7	reviewed	AL14E_HUMAN	ARL14 effector protein (ARF7 effector protein)	ARL14EP ARF7EP C11orf46	Homo sapiens (Human)	260	FUNCTION: Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. {ECO:0000269|PubMed:21458045}.			cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21458045}.
Q8N8S7	reviewed	ENAH_HUMAN	Protein enabled homolog	ENAH MENA	Homo sapiens (Human)	591	FUNCTION: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}.	MISCELLANEOUS: Required to transform actin polymerization into active movement for the propulsive force of Listeria monocytogenes. {ECO:0000250}.; MISCELLANEOUS: [Isoform 3]: Expression restricted to invasive cancer cells. {ECO:0000305}.	actin polymerization or depolymerization [GO:0008154]; actin polymerization-dependent cell motility [GO:0070358]; axon guidance [GO:0007411]	cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; synapse [GO:0045202]	actin binding [GO:0003779]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124]; WW domain binding [GO:0050699]	cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; synapse [GO:0045202]; actin binding [GO:0003779]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124]; WW domain binding [GO:0050699]; actin polymerization or depolymerization [GO:0008154]; actin polymerization-dependent cell motility [GO:0070358]; axon guidance [GO:0007411]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Synapse {ECO:0000250}. Cell junction, focal adhesion. Note=Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses (By similarity). {ECO:0000250}.
Q8N8U9	reviewed	BMPER_HUMAN	BMP-binding endothelial regulator protein (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2)	BMPER KIAA1965	Homo sapiens (Human)	685	FUNCTION: Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. {ECO:0000269|PubMed:14766204}.		blood vessel development [GO:0001568]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; BMP signaling pathway [GO:0030509]; endothelial cell activation [GO:0042118]; inner ear development [GO:0048839]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of angiogenesis [GO:0045765]; regulation of endothelial cell migration [GO:0010594]; regulation of protein localization [GO:0032880]; SMAD protein signal transduction [GO:0060395]; ureteric bud development [GO:0001657]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; blood vessel development [GO:0001568]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; BMP signaling pathway [GO:0030509]; endothelial cell activation [GO:0042118]; inner ear development [GO:0048839]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of angiogenesis [GO:0045765]; regulation of endothelial cell migration [GO:0010594]; regulation of protein localization [GO:0032880]; SMAD protein signal transduction [GO:0060395]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14766204}.
Q8N8V2	reviewed	GBP7_HUMAN	Guanylate-binding protein 7 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 7) (GBP-7) (Guanine nucleotide-binding protein 7) (Guanylate-binding protein 4-like)	GBP7 GBP4L	Homo sapiens (Human)	638	FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP to GMP in two consecutive cleavage reactions and predominantly uses GTP and not GDP or GMP as the substrate (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Also promotes IFN-gamma-mediated host defense against bacterial infections by regulating oxidative responses and bacteriolytic peptide generation (By similarity). May help to assemble NADPH oxidase on phagosomal membranes by acting as a bridging protein between NADPH oxidase cytosolic subunits NCF2-NCF4 and the membrane subunits CYBA-CYBB (By similarity). Participates along with GBP1 in trafficking monoubiquinated protein cargo to autolysosomes for generating ubiquitin-derived antimicrobial peptides (By similarity). Facilitates influenza A virus replication by inhibiting the activation of NF-kappaB and JAK-STAT signaling pathways and the expression of type I, type III interferons and pro-inflammatory cytokines (PubMed:33408175). Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (By similarity). Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite (By similarity). {ECO:0000250|UniProtKB:Q91Z40, ECO:0000269|PubMed:33408175}.		cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; negative regulation of cytokine production [GO:0001818]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of type I interferon production [GO:0032480]; negative regulation of type III interferon production [GO:0034345]; positive regulation of viral genome replication [GO:0045070]; regulation of canonical NF-kappaB signal transduction [GO:0043122]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; negative regulation of cytokine production [GO:0001818]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of type I interferon production [GO:0032480]; negative regulation of type III interferon production [GO:0034345]; positive regulation of viral genome replication [GO:0045070]; regulation of canonical NF-kappaB signal transduction [GO:0043122]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q91Z40}.
Q8N8V4	reviewed	ANS4B_HUMAN	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin-interacting ankyrin repeat-containing protein) (Harp)	ANKS4B HARP	Homo sapiens (Human)	417	FUNCTION: As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (PubMed:26812018). May play a role in cellular response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q8K3X6, ECO:0000269|PubMed:26812018}.		brush border assembly [GO:1904970]; cell differentiation [GO:0030154]; protein localization to microvillus [GO:1904106]; protein-containing complex assembly [GO:0065003]; response to endoplasmic reticulum stress [GO:0034976]	brush border [GO:0005903]; endoplasmic reticulum membrane [GO:0005789]; microvillus [GO:0005902]; plasma membrane [GO:0005886]		brush border [GO:0005903]; endoplasmic reticulum membrane [GO:0005789]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; brush border assembly [GO:1904970]; cell differentiation [GO:0030154]; protein localization to microvillus [GO:1904106]; protein-containing complex assembly [GO:0065003]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Cell projection, microvillus {ECO:0000269|PubMed:26812018}. Note=Localizes at the tip of microvilli (PubMed:26812018). May associate with endoplasmic reticulum membranes (By similarity). {ECO:0000250|UniProtKB:Q8K3X6, ECO:0000269|PubMed:26812018}.
Q8N8W4	reviewed	PLPL1_HUMAN	Omega-hydroxyceramide transacylase (EC 2.3.1.296) (Patatin-like phospholipase domain-containing protein 1)	PNPLA1	Homo sapiens (Human)	532	FUNCTION: Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation (PubMed:27751867, PubMed:28248318). Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide (PubMed:27751867, PubMed:28248318). Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function (PubMed:22246504, PubMed:27751867, PubMed:28248318). These lipids also play a role in keratinocyte differentiation (By similarity). May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS) (By similarity). {ECO:0000250|UniProtKB:Q3V1D5, ECO:0000269|PubMed:22246504, ECO:0000269|PubMed:27751867, ECO:0000269|PubMed:28248318}.	MISCELLANEOUS: [Isoform 2]: Inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Inactive. {ECO:0000305}.	ceramide biosynthetic process [GO:0046513]; lipid homeostasis [GO:0055088]; omega-hydroxyceramide biosynthetic process [GO:0106342]; triglyceride catabolic process [GO:0019433]	cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]	acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; omega-hydroxyceramide transacylase activity [GO:0106341]; structural constituent of skin epidermis [GO:0030280]; triglyceride lipase activity [GO:0004806]	cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; omega-hydroxyceramide transacylase activity [GO:0106341]; structural constituent of skin epidermis [GO:0030280]; triglyceride lipase activity [GO:0004806]; ceramide biosynthetic process [GO:0046513]; lipid homeostasis [GO:0055088]; omega-hydroxyceramide biosynthetic process [GO:0106342]; triglyceride catabolic process [GO:0019433]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22246504}.
Q8N8X9	reviewed	MB213_HUMAN	Protein mab-21-like 3	MAB21L3 C1orf161	Homo sapiens (Human)	362							
Q8N8Y2	reviewed	VA0D2_HUMAN	V-type proton ATPase subunit d 2 (V-ATPase subunit d 2) (Vacuolar proton pump subunit d 2)	ATP6V0D2	Homo sapiens (Human)	350	FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Regulator of osteoclast fusion and bone formation (By similarity). {ECO:0000250|UniProtKB:P61421, ECO:0000250|UniProtKB:Q80SY3}.		regulation of macroautophagy [GO:0016241]; vacuolar acidification [GO:0007035]; vacuolar transport [GO:0007034]	apical plasma membrane [GO:0016324]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane proton-transporting V-type ATPase complex [GO:0033181]; proton-transporting V-type ATPase, V0 domain [GO:0033179]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]	proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical plasma membrane [GO:0016324]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane proton-transporting V-type ATPase complex [GO:0033181]; proton-transporting V-type ATPase, V0 domain [GO:0033179]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; regulation of macroautophagy [GO:0016241]; vacuolar acidification [GO:0007035]; vacuolar transport [GO:0007034]	
Q8N912	reviewed	NRAC_HUMAN	Nutritionally-regulated adipose and cardiac enriched protein homolog	NRAC C14orf180 C14orf77	Homo sapiens (Human)	160				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q8N960	reviewed	CE120_HUMAN	Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100)	CEP120 CCDC100	Homo sapiens (Human)	986	FUNCTION: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000250|UniProtKB:Q7TSG1, ECO:0000269|PubMed:27185865}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	astral microtubule organization [GO:0030953]; centrosome cycle [GO:0007098]; cerebral cortex development [GO:0021987]; interkinetic nuclear migration [GO:0022027]; neurogenesis [GO:0022008]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of cilium assembly [GO:0045724]; positive regulation of establishment of protein localization [GO:1904951]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]		centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; astral microtubule organization [GO:0030953]; centrosome cycle [GO:0007098]; cerebral cortex development [GO:0021987]; interkinetic nuclear migration [GO:0022027]; neurogenesis [GO:0022008]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of cilium assembly [GO:0045724]; positive regulation of establishment of protein localization [GO:1904951]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Note=Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo. {ECO:0000250}.
Q8N966	reviewed	ZDH22_HUMAN	Palmitoyltransferase ZDHHC22 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 22) (DHHC-22) (zDHHC22)	ZDHHC22 C14orf59	Homo sapiens (Human)	263	FUNCTION: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (PubMed:22399288). Catalyzes the palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (PubMed:22399288). Might also mediate palmitoylation of CNN3 (By similarity). {ECO:0000250|UniProtKB:A0PK84, ECO:0000269|PubMed:22399288}.		protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16647879}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:16647879}; Multi-pass membrane protein {ECO:0000255}.
Q8N983	reviewed	RM43_HUMAN	Large ribosomal subunit protein mL43 (39S ribosomal protein L43, mitochondrial) (L43mt) (MRP-L43) (Mitochondrial ribosomal protein bMRP36a)	MRPL43	Homo sapiens (Human)	215			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q8N987	reviewed	NECA1_HUMAN	N-terminal EF-hand calcium-binding protein 1 (EF-hand calcium-binding protein 1) (Neuronal calcium-binding protein 1)	NECAB1 EFCBP1	Homo sapiens (Human)	351			blastocyst hatching [GO:0001835]; regulation of amyloid precursor protein biosynthetic process [GO:0042984]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; blastocyst hatching [GO:0001835]; regulation of amyloid precursor protein biosynthetic process [GO:0042984]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8N999	reviewed	RLIG1_HUMAN	RNA ligase 1 (EC 6.5.1.3) (RNA ligase) (Rnl)	RLIG1 C12orf29	Homo sapiens (Human)	325	FUNCTION: Functions as an RNA ligase, in vitro (PubMed:36792600). The ligation reaction entails three nucleotidyl transfer steps (PubMed:36792600). In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate (PubMed:36792600). In step 2, the ligase-AMP binds to the nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated intermediate (PubMed:36792600). In step 3, the RNA ligase directs the attack of the 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP (PubMed:36792600). Exhibits selectivity for single-stranded RNA substrates and may not have nick-sealing activity on double-stranded DNA-RNA hybrids (PubMed:36792600). May play a role in maintaining RNA integrity under stress conditions, for example in response to reactive oxygen species (ROS) (PubMed:36792600). {ECO:0000269|PubMed:36792600, ECO:0000303|PubMed:36792600}.		hematopoietic progenitor cell differentiation [GO:0002244]; protein adenylylation [GO:0018117]; response to reactive oxygen species [GO:0000302]; RNA repair [GO:0042245]		ATP binding [GO:0005524]; RNA ligase (ATP) activity [GO:0003972]	ATP binding [GO:0005524]; RNA ligase (ATP) activity [GO:0003972]; hematopoietic progenitor cell differentiation [GO:0002244]; protein adenylylation [GO:0018117]; response to reactive oxygen species [GO:0000302]; RNA repair [GO:0042245]	
Q8N9A8	reviewed	NEPR1_HUMAN	Nuclear envelope phosphatase-regulatory subunit 1 (NEP1-R1) (Transmembrane protein 188)	CNEP1R1 C16orf69 TMEM188	Homo sapiens (Human)	125	FUNCTION: Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. {ECO:0000269|PubMed:22134922}.		lipid metabolic process [GO:0006629]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein localization to nucleus [GO:0034504]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Nem1-Spo7 phosphatase complex [GO:0071595]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; Nem1-Spo7 phosphatase complex [GO:0071595]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; lipid metabolic process [GO:0006629]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein localization to nucleus [GO:0034504]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:22134922}; Multi-pass membrane protein {ECO:0000269|PubMed:22134922}. Cytoplasm {ECO:0000269|PubMed:22134922}. Note=Filamentous pattern in the cytoplasm.
Q8N9B5	reviewed	JMY_HUMAN	Junction-mediating and -regulatory protein	JMY	Homo sapiens (Human)	988	FUNCTION: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}.		'de novo' actin filament nucleation [GO:0070060]; actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cellular response to starvation [GO:0009267]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; regulation of transcription by RNA polymerase II [GO:0006357]	autophagosome membrane [GO:0000421]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; endomembrane system [GO:0012505]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; microtubule binding [GO:0008017]; transcription coactivator activity [GO:0003713]	autophagosome membrane [GO:0000421]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; endomembrane system [GO:0012505]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; microtubule binding [GO:0008017]; transcription coactivator activity [GO:0003713]; 'de novo' actin filament nucleation [GO:0070060]; actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cellular response to starvation [GO:0009267]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9QXM1}. Cytoplasmic vesicle {ECO:0000269|PubMed:30420355}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19287377, ECO:0000269|PubMed:30420355}. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:30420355}. Note=Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells. Localizes to cytoplasmic vesicles which associate with actin filament and autophagosomal membranes upon starvation-induced autophagy (PubMed:30420355). {ECO:0000250, ECO:0000269|PubMed:30420355}.
Q8N9E0	reviewed	F133A_HUMAN	Protein FAM133A	FAM133A	Homo sapiens (Human)	248							
Q8N9F0	reviewed	NAT8L_HUMAN	N-acetylaspartate synthetase (NAA synthetase) (EC 2.3.1.17) (Camello-like protein 3) (N-acetyltransferase 8-like protein)	NAT8L CML3	Homo sapiens (Human)	302	FUNCTION: Catalyzes the synthesis of N-acetylaspartate acid (NAA) from L-aspartate and acetyl-CoA (PubMed:19524112, PubMed:19807691, PubMed:20385109). Promotes dopamine uptake by regulating TNF-alpha expression (By similarity). Attenuates methamphetamine-induced inhibition of dopamine uptake (PubMed:20385109). {ECO:0000250|UniProtKB:Q3UGX3, ECO:0000269|PubMed:19524112, ECO:0000269|PubMed:19807691, ECO:0000269|PubMed:20385109}.		aspartate family amino acid metabolic process [GO:0009066]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	aspartate N-acetyltransferase activity [GO:0017188]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; aspartate N-acetyltransferase activity [GO:0017188]; aspartate family amino acid metabolic process [GO:0009066]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19524112}. Microsome membrane {ECO:0000250|UniProtKB:D3ZVU9}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:19524112}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q3UGX3}; Single-pass membrane protein {ECO:0000255}. Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment. {ECO:0000269|PubMed:19524112}.
Q8N9F7	reviewed	GDPD1_HUMAN	Lysophospholipase D GDPD1 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 4) (Glycerophosphodiester phosphodiesterase domain-containing protein 1)	GDPD1 GDE4	Homo sapiens (Human)	314	FUNCTION: Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550, PubMed:25596343). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC) (PubMed:27637550, PubMed:25596343). May be involved in bioactive N-acylethanolamine biosynthesis from both N-acyl-lysoplasmenylethanolamin (N-acyl-lysoPlsEt) and N-acyl-lysophosphatidylethanolamin (N-acyl-lysoPE) (PubMed:27637550, PubMed:25596343). In addition, hydrolyzes glycerophospho-N-acylethanolamine to N-acylethanolamine (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine (By similarity). {ECO:0000250|UniProtKB:Q9CRY7, ECO:0000269|PubMed:25596343, ECO:0000269|PubMed:27637550}.		glycerophospholipid catabolic process [GO:0046475]; N-acylethanolamine metabolic process [GO:0070291]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	lysophospholipase activity [GO:0004622]; metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; lysophospholipase activity [GO:0004622]; metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081]; glycerophospholipid catabolic process [GO:0046475]; N-acylethanolamine metabolic process [GO:0070291]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18991142}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18991142}. Endoplasmic reticulum {ECO:0000269|PubMed:27637550}. Note=Concentrated at the perinuclear region and the cell periphery (PubMed:18991142). {ECO:0000269|PubMed:18991142}.
Q8N9I0	reviewed	SYT2_HUMAN	Synaptotagmin-2 (Synaptotagmin II) (SytII)	SYT2	Homo sapiens (Human)	419	FUNCTION: Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P46097, ECO:0000269|PubMed:23999003}.		calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488]	axon [GO:0030424]; chromaffin granule membrane [GO:0042584]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]	axon [GO:0030424]; chromaffin granule membrane [GO:0042584]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P29101}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P29101}. Cytoplasm {ECO:0000250|UniProtKB:P29101}.
Q8N9I5	reviewed	FADS6_HUMAN	Fatty acid desaturase 6 (EC 1.14.19.-)	FADS6 FP18279	Homo sapiens (Human)	356			fatty acid biosynthetic process [GO:0006633]; lipid metabolic process [GO:0006629]	membrane [GO:0016020]	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]	membrane [GO:0016020]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]; fatty acid biosynthetic process [GO:0006633]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N9I9	reviewed	DTX3_HUMAN	Probable E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)	DTX3 RNF154	Homo sapiens (Human)	347	FUNCTION: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. {ECO:0000250}.		Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; transferase activity [GO:0016740]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; transferase activity [GO:0016740]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8N9L9	reviewed	ACOT4_HUMAN	Peroxisomal succinyl-coenzyme A thioesterase (EC 3.1.2.3) (Acyl-coenzyme A thioesterase 4) (Acyl-CoA thioesterase 4) (EC 3.1.2.2) (PTE-2b) (Peroxisomal acyl coenzyme A thioester hydrolase Ib) (Peroxisomal long-chain acyl-CoA thioesterase Ib) (PTE-Ib)	ACOT4 PTE2B PTEIB	Homo sapiens (Human)	421	FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16940157). Functions as a peroxisomal succinyl-coenzyme A thioesterase that can also hydrolyze glutaryl-CoA and long chain saturated acyl-CoAs (PubMed:16940157). {ECO:0000269|PubMed:16940157}.	MISCELLANEOUS: Compared to mouse peroxisomal succinyl-coenzyme A thioesterase/ACOT4, the human enzyme has a broad substrate specificity overlapping the activity of three mouse acyl-coenzyme A thioesterases, providing an explanation for the unexpectedly low number of acyl-coenzyme A thioesterase genes in the human genome. {ECO:0000303|PubMed:16940157}.	acyl-CoA metabolic process [GO:0006637]; dicarboxylic acid catabolic process [GO:0043649]; dicarboxylic acid metabolic process [GO:0043648]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid metabolic process [GO:0001676]; saturated monocarboxylic acid metabolic process [GO:0032788]; short-chain fatty acid metabolic process [GO:0046459]; succinyl-CoA metabolic process [GO:0006104]; unsaturated monocarboxylic acid metabolic process [GO:0032789]; very long-chain fatty acid metabolic process [GO:0000038]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; glutaryl-CoA hydrolase activity [GO:0044466]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; succinyl-CoA hydrolase activity [GO:0004778]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; glutaryl-CoA hydrolase activity [GO:0044466]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; succinyl-CoA hydrolase activity [GO:0004778]; acyl-CoA metabolic process [GO:0006637]; dicarboxylic acid catabolic process [GO:0043649]; dicarboxylic acid metabolic process [GO:0043648]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid metabolic process [GO:0001676]; saturated monocarboxylic acid metabolic process [GO:0032788]; short-chain fatty acid metabolic process [GO:0046459]; succinyl-CoA metabolic process [GO:0006104]; unsaturated monocarboxylic acid metabolic process [GO:0032789]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:16940157}.
Q8N9M5	reviewed	TM102_HUMAN	Transmembrane protein 102 (Common beta-chain associated protein) (CBAP)	TMEM102	Homo sapiens (Human)	508	FUNCTION: Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. {ECO:0000269|PubMed:17828305}.		apoptotic process [GO:0006915]; positive regulation of cell adhesion [GO:0045785]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T cell migration [GO:2000406]; regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901028]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to cytokine [GO:0034097]; signal transduction [GO:0007165]	cell surface [GO:0009986]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]		cell surface [GO:0009986]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; apoptotic process [GO:0006915]; positive regulation of cell adhesion [GO:0045785]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T cell migration [GO:2000406]; regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901028]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to cytokine [GO:0034097]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17828305}; Single-pass membrane protein {ECO:0000269|PubMed:17828305}. Note=Although it is found at the cell surface, the majority of the molecules seems to be located in intracellular compartments.
Q8N9N2	reviewed	ASCC1_HUMAN	Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50)	ASCC1 CGI-18	Homo sapiens (Human)	400	FUNCTION: Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:19074642, ECO:0000269|PubMed:26924529, ECO:0000269|PubMed:29997253}.		DNA dealkylation involved in DNA repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; regulation of DNA-templated transcription [GO:0006355]	DNA repair complex [GO:1990391]; neuromuscular junction [GO:0031594]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	RNA binding [GO:0003723]	DNA repair complex [GO:1990391]; neuromuscular junction [GO:0031594]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; RNA binding [GO:0003723]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:26924529}. Nucleus speckle {ECO:0000269|PubMed:29997253}. Note=Colocalizes with PRPF8 in nuclear speckles in the absence of DNA damage. {ECO:0000269|PubMed:29997253}.
Q8N9N5	reviewed	BANP_HUMAN	Protein BANP (BEN domain-containing protein 1) (Btg3-associated nuclear protein) (Scaffold/matrix-associated region-1-binding protein)	BANP BEND1 SMAR1	Homo sapiens (Human)	519	FUNCTION: Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8VBU8, ECO:0000269|PubMed:16166625}.		cell cycle [GO:0007049]; chromatin organization [GO:0006325]; negative regulation of protein catabolic process [GO:0042177]; protein localization to nucleus [GO:0034504]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; cell cycle [GO:0007049]; chromatin organization [GO:0006325]; negative regulation of protein catabolic process [GO:0042177]; protein localization to nucleus [GO:0034504]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16166625}.
Q8N9N8	reviewed	EIF1A_HUMAN	Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) (Haponin)	EIF1AD	Homo sapiens (Human)	165	FUNCTION: Plays a role into cellular response to oxidative stress. Decreases cell proliferation. {ECO:0000269|PubMed:20644585, ECO:0000269|PubMed:22095125}.			cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20644585, ECO:0000269|PubMed:22095125}.
Q8N9Q2	reviewed	SR1IP_HUMAN	Protein SREK1IP1 (SFRS12-interacting protein 1) (SREK1-interacting protein 1) (Splicing regulatory protein of 18 kDa) (p18SRP)	SREK1IP1 P18SRP SFRS12IP1	Homo sapiens (Human)	155	FUNCTION: Possible splicing regulator involved in the control of cellular survival.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]		nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	
Q8N9R8	reviewed	SCAI_HUMAN	Protein SCAI (Suppressor of cancer cell invasion protein)	SCAI C9orf126	Homo sapiens (Human)	606	FUNCTION: Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. {ECO:0000269|PubMed:19350017}.		DNA-templated transcription [GO:0006351]; negative regulation of cell migration [GO:0030336]; negative regulation of Rho protein signal transduction [GO:0035024]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription corepressor activity [GO:0003714]; DNA-templated transcription [GO:0006351]; negative regulation of cell migration [GO:0030336]; negative regulation of Rho protein signal transduction [GO:0035024]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:19350017}. Cytoplasm {ECO:0000269|PubMed:19350017}. Note=Nuclear localization is required for inhibition of MRTFA. {ECO:0000250}.
Q8N9V6	reviewed	ANR53_HUMAN	Ankyrin repeat domain-containing protein 53	ANKRD53	Homo sapiens (Human)	530	FUNCTION: Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization. {ECO:0000269|PubMed:26820536}.		cell division [GO:0051301]; mitotic metaphase chromosome alignment [GO:0007080]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cytokinesis [GO:1902412]; regulation of mitotic spindle organization [GO:0060236]	cytoplasm [GO:0005737]; spindle [GO:0005819]; spindle pole [GO:0000922]		cytoplasm [GO:0005737]; spindle [GO:0005819]; spindle pole [GO:0000922]; cell division [GO:0051301]; mitotic metaphase chromosome alignment [GO:0007080]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cytokinesis [GO:1902412]; regulation of mitotic spindle organization [GO:0060236]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26820536}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:26820536}. Note=Localizes at the spindle around the centrosome at prophase and prometaphase and at the spindle poles at metaphase and anaphase (PubMed:26820536). {ECO:0000269|PubMed:26820536}.
Q8N9W5	reviewed	DAAF3_HUMAN	Dynein axonemal assembly factor 3	DNAAF3 C19orf51	Homo sapiens (Human)	541	FUNCTION: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia. {ECO:0000269|PubMed:22387996}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	axonemal dynein complex assembly [GO:0070286]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; motile cilium assembly [GO:0044458]	dynein axonemal particle [GO:0120293]		dynein axonemal particle [GO:0120293]; axonemal dynein complex assembly [GO:0070286]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; motile cilium assembly [GO:0044458]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q32NQ7}.
Q8N9W6	reviewed	BOLL_HUMAN	Protein boule-like	BOLL BOULE	Homo sapiens (Human)	283	FUNCTION: Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity). {ECO:0000250}.		3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]	identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; translation activator activity [GO:0008494]	cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; translation activator activity [GO:0008494]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11390979, ECO:0000269|PubMed:17114206}.
Q8NA29	reviewed	NLS1_HUMAN	Sodium-dependent lysophosphatidylcholine symporter 1 (NLS1) (Sodium-dependent LPC symporter 1) (Major facilitator superfamily domain-containing protein 2A) (HsMFSD2A) (MFSD2a)	MFSD2A MFSD2 NLS1 HMFN0656 PP9177 UNQ300/PRO341	Homo sapiens (Human)	543	FUNCTION: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed:24828040, PubMed:34135507, PubMed:32572202). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed:34135507, PubMed:26005868). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation (PubMed:21677192). In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed:18988732, PubMed:23177091). {ECO:0000250|UniProtKB:Q9DA75, ECO:0000269|PubMed:18988732, ECO:0000269|PubMed:21677192, ECO:0000269|PubMed:23177091, ECO:0000269|PubMed:24828040, ECO:0000269|PubMed:26005868, ECO:0000269|PubMed:34135507}.		brain development [GO:0007420]; carbohydrate transport [GO:0008643]; cellular response to starvation [GO:0009267]; cognition [GO:0050890]; energy homeostasis [GO:0097009]; establishment of blood-brain barrier [GO:0060856]; fatty acid transport [GO:0015908]; hippocampus development [GO:0021766]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid transport [GO:0015909]; lysophospholipid translocation [GO:0140329]; lysophospholipid transport [GO:0051977]; maintenance of blood-brain barrier [GO:0035633]; motor behavior [GO:0061744]; negative regulation of fatty acid beta-oxidation [GO:0031999]; organic substance transport [GO:0071702]; phosphatidylcholine biosynthetic process [GO:0006656]; photoreceptor cell morphogenesis [GO:0008594]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of cell growth [GO:0030307]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of dendrite development [GO:0050773]; regulation of multicellular organism growth [GO:0040014]; regulation of neuron projection arborization [GO:0150011]; regulation of phosphatidylcholine metabolic process [GO:0150172]; regulation of phosphatidylethanolamine metabolic process [GO:0150175]; regulation of phosphatidylserine metabolic process [GO:0150178]; retina morphogenesis in camera-type eye [GO:0060042]; retinal pigment epithelium development [GO:0003406]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]; very-low-density lipoprotein particle assembly [GO:0034379]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; lysophosphatidylcholine flippase activity [GO:0140348]; lysophospholipid:sodium symporter activity [GO:0051978]; oleate transmembrane transporter activity [GO:1901480]; phospholipid transporter activity [GO:0005548]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; lysophosphatidylcholine flippase activity [GO:0140348]; lysophospholipid:sodium symporter activity [GO:0051978]; oleate transmembrane transporter activity [GO:1901480]; phospholipid transporter activity [GO:0005548]; brain development [GO:0007420]; carbohydrate transport [GO:0008643]; cellular response to starvation [GO:0009267]; cognition [GO:0050890]; energy homeostasis [GO:0097009]; establishment of blood-brain barrier [GO:0060856]; fatty acid transport [GO:0015908]; hippocampus development [GO:0021766]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid transport [GO:0015909]; lysophospholipid translocation [GO:0140329]; lysophospholipid transport [GO:0051977]; maintenance of blood-brain barrier [GO:0035633]; motor behavior [GO:0061744]; negative regulation of fatty acid beta-oxidation [GO:0031999]; organic substance transport [GO:0071702]; phosphatidylcholine biosynthetic process [GO:0006656]; photoreceptor cell morphogenesis [GO:0008594]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of cell growth [GO:0030307]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of dendrite development [GO:0050773]; regulation of multicellular organism growth [GO:0040014]; regulation of neuron projection arborization [GO:0150011]; regulation of phosphatidylcholine metabolic process [GO:0150172]; regulation of phosphatidylethanolamine metabolic process [GO:0150175]; regulation of phosphatidylserine metabolic process [GO:0150178]; retina morphogenesis in camera-type eye [GO:0060042]; retinal pigment epithelium development [GO:0003406]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]; very-low-density lipoprotein particle assembly [GO:0034379]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26005868, ECO:0000269|PubMed:32572202}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9DA75}; Multi-pass membrane protein {ECO:0000255}. Note=Cytoplasmic punctae that may represent vesicles shuttling between the endoplasmic reticulum and the plasma membrane (PubMed:21677192). {ECO:0000269|PubMed:21677192}.
Q8NA31	reviewed	TERB1_HUMAN	Telomere repeats-binding bouquet formation protein 1 (Coiled-coil domain-containing protein 79)	TERB1 CCDC79	Homo sapiens (Human)	727	FUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity. {ECO:0000250|UniProtKB:Q8C0V1}.		double-strand break repair involved in meiotic recombination [GO:1990918]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141]	chromosome, telomeric region [GO:0000781]; nuclear inner membrane [GO:0005637]; shelterin complex [GO:0070187]		chromosome, telomeric region [GO:0000781]; nuclear inner membrane [GO:0005637]; shelterin complex [GO:0070187]; double-strand break repair involved in meiotic recombination [GO:1990918]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141]	SUBCELLULAR LOCATION: Chromosome, telomere {ECO:0000250|UniProtKB:Q8C0V1}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q8C0V1}. Note=Localizes to telomeres during meiotic prophase. In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. {ECO:0000250|UniProtKB:Q8C0V1}.
Q8NA42	reviewed	ZN383_HUMAN	Zinc finger protein 383	ZNF383 HSD17	Homo sapiens (Human)	475	FUNCTION: May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways. {ECO:0000269|PubMed:15964543}.		regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15964543}. Cytoplasm {ECO:0000269|PubMed:15964543}. Note=Shuttling between the nucleus and cytoplasm may occur under different stimulation and growth conditions.
Q8NA54	reviewed	IQUB_HUMAN	IQ and ubiquitin-like domain-containing protein	IQUB	Homo sapiens (Human)	791	FUNCTION: Adapter protein that anchors the radial spoke 1 (RS1) complex to the A microtubule of outer doublet microtubules in axonemes (PubMed:36355624). The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum (PubMed:36355624). May play a role in inhibiting signaling via MAPK1/ERK2 and MAPK3/ERK1 (PubMed:36355624). Additionally, may play a role in the functioning of cilia (By similarity). Not required for the functioning of tracheal or ependymal cilia (By similarity). {ECO:0000250|UniProtKB:Q8CDK3, ECO:0000269|PubMed:36355624}.		cilium assembly [GO:0060271]; smoothened signaling pathway [GO:0007224]	acrosomal vesicle [GO:0001669]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]		acrosomal vesicle [GO:0001669]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; cilium assembly [GO:0060271]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q8CDK3}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8CDK3}. Note=Localizes to the axoneme of sperm cells and the cilia of tracheal epithelial cells. {ECO:0000250|UniProtKB:Q8CDK3}.
Q8NA56	reviewed	TTC29_HUMAN	Tetratricopeptide repeat protein 29 (TPR repeat protein 29) (Protein TBPP2A) (Testis development protein NYD-SP14)	TTC29	Homo sapiens (Human)	475	FUNCTION: Axonemal protein which is implicated in axonemal and/or peri-axonemal structures assembly and regulates flagella assembly and beating and therefore sperm motility. {ECO:0000269|PubMed:31735292, ECO:0000269|PubMed:31735294}.		cilium movement [GO:0003341]; cilium organization [GO:0044782]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126]; cilium movement [GO:0003341]; cilium organization [GO:0044782]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:31735292, ECO:0000269|PubMed:31735294}.
Q8NA58	reviewed	PNDC1_HUMAN	Poly(A)-specific ribonuclease PNLDC1 (EC 3.1.13.4) (PARN-like domain-containing protein 1) (Poly(A)-specific ribonuclease domain-containing protein 1) (HsPNLDC1)	PNLDC1	Homo sapiens (Human)	520	FUNCTION: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (By similarity). Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs (PubMed:34347949). {ECO:0000250|UniProtKB:B2RXZ1, ECO:0000269|PubMed:27515512, ECO:0000269|PubMed:34347949}.		blastocyst formation [GO:0001825]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723]; blastocyst formation [GO:0001825]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27515512}; Single-pass membrane protein {ECO:0000305}. Note=Localizes mainly in the endoplasmic reticulum (PubMed:27515512). {ECO:0000269|PubMed:27515512}.
Q8NA61	reviewed	CBY2_HUMAN	Protein chibby homolog 2 (Spermatid-associated protein)	CBY2 SPERT	Homo sapiens (Human)	448				cytoplasmic vesicle [GO:0031410]	identical protein binding [GO:0042802]	cytoplasmic vesicle [GO:0031410]; identical protein binding [GO:0042802]	
Q8NA72	reviewed	POC5_HUMAN	Centrosomal protein POC5 (Protein of centriole 5) (hPOC5)	POC5 C5orf37	Homo sapiens (Human)	575	FUNCTION: Essential for the assembly of the distal half of centrioles, required for centriole elongation. {ECO:0000269|PubMed:19349582}.		cell cycle [GO:0007049]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]		centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; cell cycle [GO:0007049]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:19349582}. Note=Localized to the distal portion of centrioles.
Q8NA77	reviewed	TEX19_HUMAN	Testis-expressed protein 19	TEX19	Homo sapiens (Human)	164	FUNCTION: Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172). {ECO:0000250|UniProtKB:Q99MV2, ECO:0000269|PubMed:28806172}.		cell differentiation [GO:0030154]; male gonad development [GO:0008584]; male meiotic nuclear division [GO:0007140]; placenta development [GO:0001890]; reciprocal meiotic recombination [GO:0007131]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	piRNA binding [GO:0034584]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; piRNA binding [GO:0034584]; cell differentiation [GO:0030154]; male gonad development [GO:0008584]; male meiotic nuclear division [GO:0007140]; placenta development [GO:0001890]; reciprocal meiotic recombination [GO:0007131]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99MV2}. Note=Was initially reported to localize in the nucleus. However, it was later shown to localize in cytoplasm only. Cytoplasmic localization is distinct from the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q99MV2}.
Q8NA82	reviewed	MARHA_HUMAN	Probable E3 ubiquitin-protein ligase MARCHF10 (EC 2.3.2.27) (Membrane-associated RING finger protein 10) (Membrane-associated RING-CH protein X) (MARCH-X) (RING finger protein 190) (RING-type E3 ubiquitin transferase MARCHF10)	MARCHF10 MARCH10 RNF190	Homo sapiens (Human)	808	FUNCTION: E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000305}.		protein ubiquitination [GO:0016567]		transferase activity [GO:0016740]; zinc ion binding [GO:0008270]	transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]	
Q8NAC3	reviewed	I17RC_HUMAN	Interleukin-17 receptor C (IL-17 receptor C) (IL-17RC) (Interleukin-17 receptor homolog) (IL17Rhom) (Interleukin-17 receptor-like protein) (IL-17RL) (ZcytoR14)	IL17RC UNQ6118/PRO20040/PRO38901	Homo sapiens (Human)	791	FUNCTION: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:16785495, PubMed:32187518). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:18684971, PubMed:17911633). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). {ECO:0000250|UniProtKB:Q8K4C2, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:32187518}.; FUNCTION: [Isoform 5]: Receptor for both IL17A and IL17F. {ECO:0000269|PubMed:16785495}.; FUNCTION: [Isoform 6]: Does not bind IL17A or IL17F. {ECO:0000269|PubMed:16785495}.; FUNCTION: [Isoform 7]: Does not bind IL17A or IL17F. {ECO:0000269|PubMed:16785495}.; FUNCTION: [Isoform 8]: Receptor for both IL17A and IL17F. {ECO:0000269|PubMed:16785495}.		defense response to fungus [GO:0050832]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; interleukin-17A-mediated signaling pathway [GO:0038173]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-6 production [GO:0032755]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	coreceptor activity [GO:0015026]; interleukin-17 receptor activity [GO:0030368]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; coreceptor activity [GO:0015026]; interleukin-17 receptor activity [GO:0030368]; signaling receptor binding [GO:0005102]; defense response to fungus [GO:0050832]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; interleukin-17A-mediated signaling pathway [GO:0038173]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-6 production [GO:0032755]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17911633}; Single-pass type I membrane protein {ECO:0000255}. Note=Soluble isoforms may be produced.
Q8NAG6	reviewed	ANKL1_HUMAN	Ankyrin repeat and LEM domain-containing protein 1 (EC 3.1.-.-) (Ankyrin repeat domain-containing protein 41) (LEM-domain containing protein 3)	ANKLE1 ANKRD41 LEM3	Homo sapiens (Human)	615	FUNCTION: Endonuclease that probably plays a role in the DNA damage response and DNA repair. {ECO:0000269|PubMed:22399800, ECO:0000269|PubMed:27245214}.		DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of mitotic recombination [GO:0045950]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; protein export from nucleus [GO:0006611]; regulation of lymphoid progenitor cell differentiation [GO:1905456]; regulation of myeloid progenitor cell differentiation [GO:1905453]; resolution of meiotic recombination intermediates [GO:0000712]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	DNA endonuclease activity [GO:0004520]; endonuclease activity [GO:0004519]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA endonuclease activity [GO:0004520]; endonuclease activity [GO:0004519]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of mitotic recombination [GO:0045950]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; protein export from nucleus [GO:0006611]; regulation of lymphoid progenitor cell differentiation [GO:1905456]; regulation of myeloid progenitor cell differentiation [GO:1905453]; resolution of meiotic recombination intermediates [GO:0000712]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22399800, ECO:0000269|PubMed:27245214}. Nucleus {ECO:0000269|PubMed:22399800, ECO:0000269|PubMed:27245214}. Note=At the steady state, localizes predominantly in the cytoplasm. {ECO:0000269|PubMed:22399800, ECO:0000269|PubMed:27245214}.
Q8NAM6	reviewed	ZSCA4_HUMAN	Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494)	ZSCAN4 ZNF494	Homo sapiens (Human)	433	FUNCTION: Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity). {ECO:0000250}.		negative regulation of mitotic recombination [GO:0045950]; regulation of transcription by RNA polymerase II [GO:0006357]; telomere maintenance via telomere lengthening [GO:0010833]	chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of mitotic recombination [GO:0045950]; regulation of transcription by RNA polymerase II [GO:0006357]; telomere maintenance via telomere lengthening [GO:0010833]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}. Chromosome, telomere {ECO:0000250}.
Q8NAN2	reviewed	MIGA1_HUMAN	Mitoguardin 1 (Protein FAM73A)	MIGA1 FAM73A	Homo sapiens (Human)	632	FUNCTION: Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}.		mitochondrial fusion [GO:0008053]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; mitochondrial fusion [GO:0008053]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:26711011}; Single-pass membrane protein {ECO:0000255}.
Q8NAP3	reviewed	ZBT38_HUMAN	Zinc finger and BTB domain-containing protein 38	ZBTB38	Homo sapiens (Human)	1195	FUNCTION: Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}.		DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]	blood microparticle [GO:0072562]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	blood microparticle [GO:0072562]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16354688}. Chromosome {ECO:0000269|PubMed:16354688}. Note=Localizes to chromocenters. {ECO:0000269|PubMed:16354688}.
Q8NAP8	reviewed	ZBT8B_HUMAN	Zinc finger and BTB domain-containing protein 8B	ZBTB8B	Homo sapiens (Human)	495	FUNCTION: May be involved in transcriptional regulation.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NAT1	reviewed	PMGT2_HUMAN	Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2) (EC 2.4.1.312) (Extracellular O-linked N-acetylglucosamine transferase-like) (Glycosyltransferase-like domain-containing protein 2)	POMGNT2 AGO61 C3orf39 EOGTL GTDC2	Homo sapiens (Human)	580	FUNCTION: O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. {ECO:0000269|PubMed:23929950, ECO:0000269|PubMed:27066570}.		neuron migration [GO:0001764]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	acetylglucosaminyltransferase activity [GO:0008375]; protein O-acetylglucosaminyltransferase activity [GO:0097363]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; acetylglucosaminyltransferase activity [GO:0008375]; protein O-acetylglucosaminyltransferase activity [GO:0097363]; neuron migration [GO:0001764]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23929950, ECO:0000269|PubMed:27066570}; Single-pass type II membrane protein {ECO:0000269|PubMed:23929950}.
Q8NAU1	reviewed	FNDC5_HUMAN	Fibronectin type III domain-containing protein 5 (Fibronectin type III repeat-containing protein 2) [Cleaved into: Irisin]	FNDC5 FRCP2	Homo sapiens (Human)	212	FUNCTION: [Irisin]: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. {ECO:0000269|PubMed:24040023}.		positive regulation of brown fat cell differentiation [GO:0090336]; response to muscle activity [GO:0014850]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]	hormone activity [GO:0005179]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]; hormone activity [GO:0005179]; positive regulation of brown fat cell differentiation [GO:0090336]; response to muscle activity [GO:0014850]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22237023}; Single-pass type I membrane protein {ECO:0000269|PubMed:22237023}. Peroxisome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Imported in peroxisomes through the PEX5 receptor pathway. {ECO:0000250}.; SUBCELLULAR LOCATION: [Irisin]: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise. {ECO:0000269|PubMed:22237023}.
Q8NAV1	reviewed	PR38A_HUMAN	Pre-mRNA-splicing factor 38A	PRPF38A	Homo sapiens (Human)	312	FUNCTION: Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:26673105, ECO:0000269|PubMed:28781166}.		mRNA splicing, via spliceosome [GO:0000398]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28781166}.
Q8NAX2	reviewed	KDF1_HUMAN	Keratinocyte differentiation factor 1	KDF1 C1orf172	Homo sapiens (Human)	398	FUNCTION: Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250|UniProtKB:A2A9F4}.		developmental growth [GO:0048589]; establishment of skin barrier [GO:0061436]; keratinocyte development [GO:0003334]; keratinocyte proliferation [GO:0043616]; limb epidermis development [GO:0060887]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of stem cell proliferation [GO:2000647]; positive regulation of epidermal cell differentiation [GO:0045606]; regulation of epidermal cell division [GO:0010482]; stem cell proliferation [GO:0072089]	anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]		anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; developmental growth [GO:0048589]; establishment of skin barrier [GO:0061436]; keratinocyte development [GO:0003334]; keratinocyte proliferation [GO:0043616]; limb epidermis development [GO:0060887]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of stem cell proliferation [GO:2000647]; positive regulation of epidermal cell differentiation [GO:0045606]; regulation of epidermal cell division [GO:0010482]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2A9F4}. Cell junction {ECO:0000250|UniProtKB:A2A9F4}. Note=Localized at cell borders in single layered keratinocytes. Localized at cell borders in the basal and spinous layers but is more diffusely localized in the granular layer. Colocalized with actin near the cell membrane, especially in cellular protrusions (By similarity). {ECO:0000250|UniProtKB:A2A9F4}.
Q8NB12	reviewed	SMYD1_HUMAN	Histone-lysine N-methyltransferase SMYD1 (EC 2.1.1.354) (SET and MYND domain-containing protein 1)	SMYD1	Homo sapiens (Human)	490	FUNCTION: Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis. {ECO:0000250|UniProtKB:P97443}.		heart development [GO:0007507]; methylation [GO:0032259]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; skeletal muscle cell differentiation [GO:0035914]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone H3K4 trimethyltransferase activity [GO:0140999]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone H3K4 trimethyltransferase activity [GO:0140999]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; heart development [GO:0007507]; methylation [GO:0032259]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q8NB14	reviewed	UBP38_HUMAN	Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.4.19.12) (Deubiquitinating enzyme 38) (HP43.8KD) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38)	USP38 KIAA1891	Homo sapiens (Human)	1042	FUNCTION: Deubiquitinating enzyme that plays a role in various cellular processes, including DNA repair, cell cycle regulation, and immune response (PubMed:22689415, PubMed:30497519, PubMed:31874856, PubMed:35238669). Plays a role in the inhibition of type I interferon signaling by mediating the 'Lys-33' to 'Lys-48' ubiquitination transition of TBK1 leading to its degradation (PubMed:27692986). Cleaves the ubiquitin chain from the histone demethylase LSD1/KDM1A and prevents it from degradation by the 26S proteasome, thus maintaining LSD1 protein level in cells (PubMed:30497519). Plays a role in the DNA damage response by regulating the deacetylase activity of HDAC1 (PubMed:31874856). Mechanistically, removes the 'Lys-63'-linked ubiquitin chain promoting the deacetylase activity of HDAC1 in response to DNA damage (PubMed:31874856). Acts also as a specific deubiquitinase of histone deacetylase 3/HDAC3 and cleaves its 'Lys-63'-linked ubiquitin chains to lower its histone deacetylase activity (PubMed:32404892). Regulates MYC levels and cell proliferation via antagonizing ubiquitin E3 ligase FBXW7 thereby preventing MYC 'Lys-48'-linked ubiquitination and degradation (PubMed:34102342). Participates in antiviral response by removing both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of Zika virus envelope protein E (PubMed:34696459). Constitutively associated with IL-33R/IL1RL1, deconjugates its 'Lys-27'-linked polyubiquitination resulting in its autophagic degradation (PubMed:35238669). {ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:27692986, ECO:0000269|PubMed:30497519, ECO:0000269|PubMed:31874856, ECO:0000269|PubMed:32404892, ECO:0000269|PubMed:34102342, ECO:0000269|PubMed:34696459, ECO:0000269|PubMed:35238669}.		negative regulation of innate immune response [GO:0045824]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; protein sequestering activity [GO:0140311]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; protein sequestering activity [GO:0140311]; negative regulation of innate immune response [GO:0045824]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27692986, ECO:0000269|PubMed:34696459}. Nucleus {ECO:0000269|PubMed:31874856}. Note=In response to DNA damage, recruited to DNA damage sites in the nucleus. {ECO:0000269|PubMed:31874856}.
Q8NB15	reviewed	ZN511_HUMAN	Zinc finger protein 511	ZNF511	Homo sapiens (Human)	252	FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NB16	reviewed	MLKL_HUMAN	Mixed lineage kinase domain-like protein (hMLKL)	MLKL	Homo sapiens (Human)	471	FUNCTION: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610). {ECO:0000250|UniProtKB:Q9D2Y4, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:29883610}.	MISCELLANEOUS: Interaction with RIPK3 is species specific: human MLKL only interacts with human RIPK3 and not mouse RIPK3. {ECO:0000305|PubMed:22265413}.	cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; execution phase of necroptosis [GO:0097528]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; protein homotrimerization [GO:0070207]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; execution phase of necroptosis [GO:0097528]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; protein homotrimerization [GO:0070207]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24316671}. Cell membrane {ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:29883610}. Nucleus {ECO:0000250|UniProtKB:Q9D2Y4}. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). {ECO:0000250|UniProtKB:Q9D2Y4, ECO:0000269|PubMed:24316671}.
Q8NB25	reviewed	F184A_HUMAN	Protein FAM184A	FAM184A C6orf60	Homo sapiens (Human)	1140				centriolar satellite [GO:0034451]; extracellular space [GO:0005615]; P-body [GO:0000932]		centriolar satellite [GO:0034451]; extracellular space [GO:0005615]; P-body [GO:0000932]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:33957083}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to cytoplasmic foci in both interphase and mitotic cells. {ECO:0000269|PubMed:33957083}.
Q8NB49	reviewed	AT11C_HUMAN	Phospholipid-transporting ATPase IG (EC 7.6.2.1) (ATPase IQ) (ATPase class VI type 11C) (P4-ATPase flippase complex alpha subunit ATP11C)	ATP11C ATPIG ATPIQ	Homo sapiens (Human)	1132	FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:32493773, PubMed:24904167, PubMed:26567335). Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages (PubMed:26944472). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity). {ECO:0000250|UniProtKB:Q9QZW0, ECO:0000269|PubMed:24904167, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:26944472, ECO:0000269|PubMed:32493773}.		monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]	early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556]	early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25315773}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25315773}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:29123098}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:29123098}; Multi-pass membrane protein {ECO:0000255}. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Internalized via clathrin-dependent endocytosis in response to ca(2+) signaling induced by G-protein coupled serotonin and histamine receptors. {ECO:0000269|PubMed:29123098}.
Q8NB59	reviewed	SYT14_HUMAN	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV)	SYT14	Homo sapiens (Human)	555	FUNCTION: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.			membrane [GO:0016020]	phospholipid binding [GO:0005543]	membrane [GO:0016020]; phospholipid binding [GO:0005543]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:21835308}; Single-pass type III membrane protein {ECO:0000269|PubMed:21835308}. Note=Localized in perinuclear and submembranous regions.
Q8NB66	reviewed	UN13C_HUMAN	Protein unc-13 homolog C (Munc13-3)	UNC13C	Homo sapiens (Human)	2214	FUNCTION: May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity). {ECO:0000250}.		chemical synaptic transmission [GO:0007268]; dense core granule priming [GO:0061789]; negative regulation of synaptic plasticity [GO:0031914]; neuromuscular junction development [GO:0007528]; presynaptic dense core vesicle exocytosis [GO:0099525]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle priming [GO:0016082]	calyx of Held [GO:0044305]; neuromuscular junction [GO:0031594]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543]; syntaxin-1 binding [GO:0017075]	calyx of Held [GO:0044305]; neuromuscular junction [GO:0031594]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543]; syntaxin-1 binding [GO:0017075]; chemical synaptic transmission [GO:0007268]; dense core granule priming [GO:0061789]; negative regulation of synaptic plasticity [GO:0031914]; neuromuscular junction development [GO:0007528]; presynaptic dense core vesicle exocytosis [GO:0099525]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle priming [GO:0016082]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized to presynaptic structures. {ECO:0000250}.
Q8NB78	reviewed	KDM1B_HUMAN	Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B)	KDM1B AOF1 C6orf193 LSD2	Homo sapiens (Human)	822	FUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:30970244). {ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23357850, ECO:0000269|PubMed:30970244}.		genomic imprinting [GO:0071514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression by genomic imprinting [GO:0006349]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; FAD binding [GO:0071949]; FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; flavin adenine dinucleotide binding [GO:0050660]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; FAD binding [GO:0071949]; FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; flavin adenine dinucleotide binding [GO:0050660]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270]; genomic imprinting [GO:0071514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression by genomic imprinting [GO:0006349]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:30970244}. Chromosome {ECO:0000305|PubMed:30970244}. Note=Found in actively RNAPolII-transcribed gene bodies. {ECO:0000305|PubMed:30970244}.
Q8NB90	reviewed	AFG2A_HUMAN	ATPase family gene 2 protein homolog A (EC 3.6.4.10) (AFG2 AAA ATPase homolog A) (Ribosome biogenesis protein SPATA5) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5)	AFG2A SPAF SPATA5	Homo sapiens (Human)	893	FUNCTION: ATP-dependent chaperone, which plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). Acts together with AFG2B, AIRIM and CINP (PubMed:35354024). May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3UMC0, ECO:0000269|PubMed:35354024}.		brain development [GO:0007420]; cell differentiation [GO:0030154]; ribosomal large subunit biogenesis [GO:0042273]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; spindle [GO:0005819]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; spindle [GO:0005819]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275]; brain development [GO:0007420]; cell differentiation [GO:0030154]; ribosomal large subunit biogenesis [GO:0042273]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18445686}. Mitochondrion {ECO:0000250|UniProtKB:Q3UMC0}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}.
Q8NBB4	reviewed	ZSCA1_HUMAN	Zinc finger and SCAN domain-containing protein 1	ZSCAN1	Homo sapiens (Human)	408	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q8NBD8	reviewed	T229B_HUMAN	Transmembrane protein 229B	TMEM229B C14orf83	Homo sapiens (Human)	167			macrophage activation [GO:0042116]; response to bacterium [GO:0009617]	membrane [GO:0016020]		membrane [GO:0016020]; macrophage activation [GO:0042116]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NBF1	reviewed	GLIS1_HUMAN	Zinc finger protein GLIS1 (GLI-similar 1)	GLIS1	Homo sapiens (Human)	620	FUNCTION: Acts as both a repressor and activator of transcription (PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (By similarity). {ECO:0000250|UniProtKB:Q8K1M4, ECO:0000269|PubMed:21654807}.		cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8K1M4}.
Q8NBF2	reviewed	NHLC2_HUMAN	NHL repeat-containing protein 2	NHLRC2	Homo sapiens (Human)	726	FUNCTION: Required for normal embryonic development. {ECO:0000250|UniProtKB:Q8BZW8}.			cytosol [GO:0005829]; extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093]		cytosol [GO:0005829]; extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:30239752}.
Q8NBI2	reviewed	CYAC3_HUMAN	Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (EC 7.2.1.3) (Cytochrome b ascorbate-dependent protein 3) (Cytochrome b561 family member A3) (Lysosomal cytochrome b) (LCytb)	CYB561A3 CYBASC3 PSEC0259	Homo sapiens (Human)	242	FUNCTION: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis. {ECO:0000250|UniProtKB:Q6P1H1}.		intracellular iron ion homeostasis [GO:0006879]	intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nucleolus [GO:0005730]	metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; transmembrane ascorbate ferrireductase activity [GO:0140571]	intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nucleolus [GO:0005730]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; transmembrane ascorbate ferrireductase activity [GO:0140571]; intracellular iron ion homeostasis [GO:0006879]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q6P1H1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}.
Q8NBI3	reviewed	DRAXI_HUMAN	Draxin (Dorsal inhibitory axon guidance protein) (Dorsal repulsive axon guidance protein) (Neucrin)	DRAXIN C1orf187 PSEC0258 UNQ3119/PRO10268	Homo sapiens (Human)	349	FUNCTION: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. {ECO:0000255|HAMAP-Rule:MF_03060}.		anterior commissure morphogenesis [GO:0021960]; axon guidance [GO:0007411]; commissural neuron differentiation in spinal cord [GO:0021528]; dorsal spinal cord development [GO:0021516]; forebrain development [GO:0030900]; hippocampal neuron apoptotic process [GO:0110088]; negative regulation of axon extension [GO:0030517]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; Wnt signaling pathway [GO:0016055]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; anterior commissure morphogenesis [GO:0021960]; axon guidance [GO:0007411]; commissural neuron differentiation in spinal cord [GO:0021528]; dorsal spinal cord development [GO:0021516]; forebrain development [GO:0030900]; hippocampal neuron apoptotic process [GO:0110088]; negative regulation of axon extension [GO:0030517]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8NBI5	reviewed	S43A3_HUMAN	Equilibrative nucleobase transporter 1 (Protein FOAP-13) (Solute carrier family 43 member 3)	SLC43A3 ENBT1 PSEC0252	Homo sapiens (Human)	491	FUNCTION: Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobases such as adenine, guanine and hypoxanthine (PubMed:26455426, PubMed:32339528). May regulate fatty acid (FA) transport in adipocytes, acting as a positive regulator of FA efflux and as a negative regulator of FA uptake (By similarity). {ECO:0000250|UniProtKB:A2AVZ9, ECO:0000269|PubMed:26455426, ECO:0000269|PubMed:32339528}.; FUNCTION: [Isoform 1]: Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobase adenine (PubMed:30910793). Mediates the influx and efflux of the purine nucleobase analog drug 6-mercaptopurine across the membrane (PubMed:30910793). {ECO:0000269|PubMed:30910793}.; FUNCTION: [Isoform 2]: Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobase adenine (PubMed:30910793). Mediates the influx and efflux of the purine nucleobase analog drug 6-mercaptopurine across the membrane (PubMed:30910793). {ECO:0000269|PubMed:30910793}.		hypoxanthine transport [GO:0035344]	basolateral plasma membrane [GO:0016323]	adenine transmembrane transporter activity [GO:0015207]; fatty acid transmembrane transporter activity [GO:0015245]; guanine transmembrane transporter activity [GO:0015208]; xenobiotic transmembrane transporter activity [GO:0042910]	basolateral plasma membrane [GO:0016323]; adenine transmembrane transporter activity [GO:0015207]; fatty acid transmembrane transporter activity [GO:0015245]; guanine transmembrane transporter activity [GO:0015208]; xenobiotic transmembrane transporter activity [GO:0042910]; hypoxanthine transport [GO:0035344]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:26455426}; Multi-pass membrane protein {ECO:0000255}.
Q8NBI6	reviewed	XXLT1_HUMAN	Xyloside xylosyltransferase 1 (EC 2.4.2.62) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase)	XXYLT1 C3orf21 PSEC0251	Homo sapiens (Human)	393	FUNCTION: Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869). {ECO:0000269|PubMed:22117070, ECO:0000269|PubMed:8982869}.		O-glycan processing [GO:0016266]	endoplasmic reticulum membrane [GO:0005789]	magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyl alpha-1,3-xylosyltransferase activity [GO:0140560]	endoplasmic reticulum membrane [GO:0005789]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyl alpha-1,3-xylosyltransferase activity [GO:0140560]; O-glycan processing [GO:0016266]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22117070}; Single-pass type II membrane protein {ECO:0000269|PubMed:22117070}.
Q8NBJ4	reviewed	GOLM1_HUMAN	Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2)	GOLM1 C9orf155 GOLPH2 PSEC0242 UNQ686/PRO1326	Homo sapiens (Human)	401	FUNCTION: Unknown. Cellular response protein to viral infection.		nucleus organization [GO:0006997]; regulation of lipid metabolic process [GO:0019216]	endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]		endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; nucleus organization [GO:0006997]; regulation of lipid metabolic process [GO:0019216]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10831838, ECO:0000269|PubMed:12191016}; Single-pass type II membrane protein {ECO:0000269|PubMed:10831838, ECO:0000269|PubMed:12191016}. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.
Q8NBJ5	reviewed	GT251_HUMAN	Procollagen galactosyltransferase 1 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 1) (ColGalT 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1)	COLGALT1 GLT25D1 PSEC0241	Homo sapiens (Human)	622	FUNCTION: Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen (PubMed:19075007, PubMed:22216269, PubMed:27402836). By acting on collagen glycosylation, facilitates the formation of collagen triple helix (PubMed:27402836). Also involved in the biosynthesis of collagen type IV (PubMed:30412317). {ECO:0000269|PubMed:19075007, ECO:0000269|PubMed:22216269, ECO:0000269|PubMed:27402836, ECO:0000269|PubMed:30412317}.		collagen fibril organization [GO:0030199]; positive regulation of collagen fibril organization [GO:1904028]	endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]	procollagen galactosyltransferase activity [GO:0050211]	endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]; procollagen galactosyltransferase activity [GO:0050211]; collagen fibril organization [GO:0030199]; positive regulation of collagen fibril organization [GO:1904028]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:20470363}. Note=Colocalized with PLOD3 and mannose binding lectin/MBL2. {ECO:0000269|PubMed:20470363}.
Q8NBJ7	reviewed	SUMF2_HUMAN	Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2)	SUMF2 PSEC0171 UNQ1968/PRO4500	Homo sapiens (Human)	301	FUNCTION: Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010}.			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010, ECO:0000269|PubMed:18266766}.
Q8NBJ9	reviewed	SIDT2_HUMAN	SID1 transmembrane family member 2	SIDT2 CGI-40 PSEC0072 UNQ685/PRO1325	Homo sapiens (Human)	832	FUNCTION: Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity). {ECO:0000250|UniProtKB:Q8CIF6, ECO:0000269|PubMed:27046251, ECO:0000269|PubMed:27846365, ECO:0000269|PubMed:28277980}.		cell morphogenesis [GO:0000902]; glucose homeostasis [GO:0042593]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; response to glucose [GO:0009749]; RNA catabolic process [GO:0006401]; RNA transport [GO:0050658]; type B pancreatic cell development [GO:0003323]; type B pancreatic cell proliferation [GO:0044342]	lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	AP-1 adaptor complex binding [GO:0035650]; AP-2 adaptor complex binding [GO:0035612]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; nucleic acid transmembrane transporter activity [GO:0051032]; RNA transmembrane transporter activity [GO:0051033]	lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; AP-1 adaptor complex binding [GO:0035650]; AP-2 adaptor complex binding [GO:0035612]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; nucleic acid transmembrane transporter activity [GO:0051032]; RNA transmembrane transporter activity [GO:0051033]; cell morphogenesis [GO:0000902]; glucose homeostasis [GO:0042593]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; response to glucose [GO:0009749]; RNA catabolic process [GO:0006401]; RNA transport [GO:0050658]; type B pancreatic cell development [GO:0003323]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:28277980}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319}. Cell membrane {ECO:0000269|PubMed:28277980}. Note=Mainly localizes to lysosomes and only partly to the plasma membrane (PubMed:28277980). Lysosomal localization is required for SIDT2-mediated intracellular degradation of endogenous RNA (By similarity). {ECO:0000250|UniProtKB:Q8CIF6, ECO:0000269|PubMed:28277980}.
Q8NBK3	reviewed	SUMF1_HUMAN	Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1)	SUMF1 PSEC0152 UNQ3037/PRO9852	Homo sapiens (Human)	374	FUNCTION: Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:25931126, PubMed:16368756, PubMed:21224894). 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:25931126, PubMed:16368756). Known substrates include GALNS, ARSA, STS and ARSE (PubMed:12757706, PubMed:15907468, PubMed:15657036). {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15657036, ECO:0000269|PubMed:15907468, ECO:0000269|PubMed:16368756, ECO:0000269|PubMed:21224894, ECO:0000269|PubMed:25931126}.	MISCELLANEOUS: The resulting 3-oxoalanine in the substrate protein is called C(alpha)-formylglycine by many authors. It should not be confused with N-formylglycine.	glycosphingolipid metabolic process [GO:0006687]; post-translational protein modification [GO:0043687]; protein oxidation [GO:0018158]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	cupric ion binding [GO:1903135]; formylglycine-generating oxidase activity [GO:0120147]; identical protein binding [GO:0042802]; oxidoreductase activity [GO:0016491]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; cupric ion binding [GO:1903135]; formylglycine-generating oxidase activity [GO:0120147]; identical protein binding [GO:0042802]; oxidoreductase activity [GO:0016491]; glycosphingolipid metabolic process [GO:0006687]; post-translational protein modification [GO:0043687]; protein oxidation [GO:0018158]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15657036, ECO:0000269|PubMed:15962010, ECO:0000269|PubMed:18266766, ECO:0000269|PubMed:21224894}.
Q8NBL1	reviewed	PGLT1_HUMAN	Protein O-glucosyltransferase 1 (EC 2.4.1.376) (CAP10-like 46 kDa protein) (hCLP46) (KTEL motif-containing protein 1) (Myelodysplastic syndromes relative protein) (O-glucosyltransferase Rumi homolog) (hRumi) (Protein O-xylosyltransferase POGLUT1) (EC 2.4.2.63)	POGLUT1 C3orf9 CLP46 KTELC1 MDSRP MDS010 UNQ490/PRO1006	Homo sapiens (Human)	392	FUNCTION: Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PubMed:27807076). Notch glucosylation does not affect Notch ligand binding (PubMed:21490058). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q8BYB9, ECO:0000269|PubMed:21081508, ECO:0000269|PubMed:21490058, ECO:0000269|PubMed:21949356, ECO:0000269|PubMed:27807076, ECO:0000269|PubMed:28775322}.		axial mesoderm development [GO:0048318]; circulatory system development [GO:0072359]; gastrulation [GO:0007369]; muscle tissue development [GO:0060537]; paraxial mesoderm development [GO:0048339]; positive regulation of Notch signaling pathway [GO:0045747]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; regulation of gastrulation [GO:0010470]; somitogenesis [GO:0001756]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	EGF-domain serine glucosyltransferase activity [GO:0140561]; EGF-domain serine xylosyltransferase activity [GO:0140562]; glucosyltransferase activity [GO:0046527]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; EGF-domain serine glucosyltransferase activity [GO:0140561]; EGF-domain serine xylosyltransferase activity [GO:0140562]; glucosyltransferase activity [GO:0046527]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252]; axial mesoderm development [GO:0048318]; circulatory system development [GO:0072359]; gastrulation [GO:0007369]; muscle tissue development [GO:0060537]; paraxial mesoderm development [GO:0048339]; positive regulation of Notch signaling pathway [GO:0045747]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; regulation of gastrulation [GO:0010470]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:16524674, ECO:0000269|PubMed:24387993, ECO:0000269|PubMed:27807076}.
Q8NBM4	reviewed	UBAC2_HUMAN	Ubiquitin-associated domain-containing protein 2 (UBA domain-containing protein 2) (Phosphoglycerate dehydrogenase-like protein 1)	UBAC2 PHGDHL1 PSEC0110	Homo sapiens (Human)	344	FUNCTION: Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (PubMed:23297223). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). {ECO:0000269|PubMed:23297223, ECO:0000269|PubMed:31073040}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein localization to endoplasmic reticulum [GO:0070972]; Wnt signaling pathway [GO:0016055]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein localization to endoplasmic reticulum [GO:0070972]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23297223}; Multi-pass membrane protein {ECO:0000255}.
Q8NBN3	reviewed	TM87A_HUMAN	Transmembrane protein 87A (Elkin1)	TMEM87A PSEC0094	Homo sapiens (Human)	555	FUNCTION: May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN) (PubMed:26157166). In one study, shown to be a component of a novel mechanoelectrical transduction pathway which is involved in cell adhesion and migration, and is thought to act either as a mechanically activated ion channel or as an accessory protein which modulates an unidentified mechanically activated ion channel (PubMed:32228863). In another study, neither basal nor mechanically activated channel activity has been observed and, based on structural similarity with WLS, has been suggested to function as a trafficking chaperone for membrane-associated cargo (PubMed:36373655). {ECO:0000269|PubMed:26157166, ECO:0000269|PubMed:32228863, ECO:0000269|PubMed:36373655}.	MISCELLANEOUS: Plays a role in positive regulation of melanoma cell migration. {ECO:0000269|PubMed:32228863}.	cellular response to mechanical stimulus [GO:0071260]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; ruffle [GO:0001726]		cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; cellular response to mechanical stimulus [GO:0071260]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:32228863}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:26157166, ECO:0000269|PubMed:32228863}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:32228863}; Multi-pass membrane protein {ECO:0000255}. Cell projection, ruffle {ECO:0000269|PubMed:32228863}.
Q8NBN7	reviewed	RDH13_HUMAN	Retinol dehydrogenase 13 (EC 1.1.1.300) (Short chain dehydrogenase/reductase family 7C member 3)	RDH13 SDR7C3 PSEC0082 UNQ736/PRO1430	Homo sapiens (Human)	331	FUNCTION: Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency (PubMed:18039331). Has no activity toward steroids (PubMed:18039331). {ECO:0000269|PubMed:18039331}.		eye photoreceptor cell development [GO:0042462]; response to high light intensity [GO:0009644]; retina layer formation [GO:0010842]; retinal metabolic process [GO:0042574]	mitochondrial inner membrane [GO:0005743]	NADP-retinol dehydrogenase activity [GO:0052650]	mitochondrial inner membrane [GO:0005743]; NADP-retinol dehydrogenase activity [GO:0052650]; eye photoreceptor cell development [GO:0042462]; response to high light intensity [GO:0009644]; retina layer formation [GO:0010842]; retinal metabolic process [GO:0042574]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:18039331}; Peripheral membrane protein {ECO:0000269|PubMed:18039331}. Note=Localized on the outer side of the inner mitochondrial membrane. {ECO:0000269|PubMed:18039331}.
Q8NBP7	reviewed	PCSK9_HUMAN	Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)	PCSK9 NARC1 PSEC0052	Homo sapiens (Human)	692	FUNCTION: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, PubMed:17461796, PubMed:18197702, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. {ECO:0000269|PubMed:17461796, ECO:0000269|PubMed:18039658, ECO:0000269|PubMed:18197702, ECO:0000269|PubMed:18660751, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22074827, ECO:0000269|PubMed:22493497, ECO:0000269|PubMed:22580899}.		apoptotic process [GO:0006915]; cellular response to insulin stimulus [GO:0032869]; cellular response to starvation [GO:0009267]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; kidney development [GO:0001822]; lipoprotein metabolic process [GO:0042157]; liver development [GO:0001889]; low-density lipoprotein particle receptor catabolic process [GO:0032802]; lysosomal transport [GO:0007041]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of low-density lipoprotein particle receptor binding [GO:1905596]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of receptor internalization [GO:0002091]; negative regulation of receptor recycling [GO:0001920]; negative regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905601]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; phospholipid metabolic process [GO:0006644]; positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of receptor internalization [GO:0002092]; protein autoprocessing [GO:0016540]; regulation of neuron apoptotic process [GO:0043523]; regulation of signaling receptor activity [GO:0010469]; triglyceride metabolic process [GO:0006641]	cell surface [GO:0009986]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extrinsic component of external side of plasma membrane [GO:0031232]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; PCSK9-AnxA2 complex [GO:1990667]; PCSK9-LDLR complex [GO:1990666]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	apolipoprotein binding [GO:0034185]; apolipoprotein receptor binding [GO:0034190]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor binding [GO:0050750]; protein self-association [GO:0043621]; RNA binding [GO:0003723]; serine-type endopeptidase activity [GO:0004252]; signaling receptor inhibitor activity [GO:0030547]; sodium channel inhibitor activity [GO:0019871]; very-low-density lipoprotein particle binding [GO:0034189]; very-low-density lipoprotein particle receptor binding [GO:0070326]	cell surface [GO:0009986]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extrinsic component of external side of plasma membrane [GO:0031232]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; PCSK9-AnxA2 complex [GO:1990667]; PCSK9-LDLR complex [GO:1990666]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; apolipoprotein binding [GO:0034185]; apolipoprotein receptor binding [GO:0034190]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor binding [GO:0050750]; protein self-association [GO:0043621]; RNA binding [GO:0003723]; serine-type endopeptidase activity [GO:0004252]; signaling receptor inhibitor activity [GO:0030547]; sodium channel inhibitor activity [GO:0019871]; very-low-density lipoprotein particle binding [GO:0034189]; very-low-density lipoprotein particle receptor binding [GO:0070326]; apoptotic process [GO:0006915]; cellular response to insulin stimulus [GO:0032869]; cellular response to starvation [GO:0009267]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; kidney development [GO:0001822]; lipoprotein metabolic process [GO:0042157]; liver development [GO:0001889]; low-density lipoprotein particle receptor catabolic process [GO:0032802]; lysosomal transport [GO:0007041]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of low-density lipoprotein particle receptor binding [GO:1905596]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of receptor internalization [GO:0002091]; negative regulation of receptor recycling [GO:0001920]; negative regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905601]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; phospholipid metabolic process [GO:0006644]; positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of receptor internalization [GO:0002092]; protein autoprocessing [GO:0016540]; regulation of neuron apoptotic process [GO:0043523]; regulation of signaling receptor activity [GO:0010469]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.
Q8NBQ5	reviewed	DHB11_HUMAN	Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2)	HSD17B11 DHRS8 PAN1B SDR16C2 PSEC0029 UNQ207/PRO233	Homo sapiens (Human)	300	FUNCTION: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.		androgen catabolic process [GO:0006710]; estrogen biosynthetic process [GO:0006703]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]	estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity [GO:0016229]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity [GO:0016229]; androgen catabolic process [GO:0006710]; estrogen biosynthetic process [GO:0006703]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9EQ06}. Lipid droplet {ECO:0000250|UniProtKB:Q9EQ06}. Note=Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation. {ECO:0000250|UniProtKB:Q9EQ06}.
Q8NBQ7	reviewed	AQP11_HUMAN	Aquaporin-11 (AQP-11)	AQP11 AQPX1 PSEC0027	Homo sapiens (Human)	271	FUNCTION: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:24845055, PubMed:24918044, PubMed:31546170). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:31546170). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (By similarity). Plays a role in the proximal tubule function by regulating its endosomal acidification (By similarity). May play a role in postnatal kidney development (By similarity). {ECO:0000250|UniProtKB:Q8BHH1, ECO:0000269|PubMed:24845055, ECO:0000269|PubMed:24918044, ECO:0000269|PubMed:31546170}.		endosomal lumen acidification [GO:0048388]; glycerol transmembrane transport [GO:0015793]; hydrogen peroxide transmembrane transport [GO:0080170]; intracellular oxygen homeostasis [GO:0032364]; intracellular water homeostasis [GO:0009992]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERAD pathway [GO:1904293]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; positive regulation of cell population proliferation [GO:0008284]; protein glycosylation [GO:0006486]; protein homooligomerization [GO:0051260]; protein targeting to membrane [GO:0006612]; proximal tubule development [GO:0072014]; water transport [GO:0006833]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	channel activity [GO:0015267]; glycerol channel activity [GO:0015254]; water channel activity [GO:0015250]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; channel activity [GO:0015267]; glycerol channel activity [GO:0015254]; water channel activity [GO:0015250]; endosomal lumen acidification [GO:0048388]; glycerol transmembrane transport [GO:0015793]; hydrogen peroxide transmembrane transport [GO:0080170]; intracellular oxygen homeostasis [GO:0032364]; intracellular water homeostasis [GO:0009992]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERAD pathway [GO:1904293]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; positive regulation of cell population proliferation [GO:0008284]; protein glycosylation [GO:0006486]; protein homooligomerization [GO:0051260]; protein targeting to membrane [GO:0006612]; proximal tubule development [GO:0072014]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:28042826}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24918044, ECO:0000269|PubMed:31546170}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:24918044}. Cytoplasm {ECO:0000250|UniProtKB:Q8BHH1}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8BHH1}. Note=Localizes mainly to the periphery of lipid droplets (PubMed:24845055). it accumulates partly in mitochondrial-associated endoplasmic reticulum membranes (PubMed:31546170). {ECO:0000269|PubMed:24845055, ECO:0000269|PubMed:31546170}.
Q8NBR6	reviewed	MINY2_HUMAN	Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B)	MINDY2 FAM63B KIAA1164	Homo sapiens (Human)	621	FUNCTION: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798). {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}.		proteolysis [GO:0006508]	nucleoplasm [GO:0005654]	cysteine-type carboxypeptidase activity [GO:0016807]; cysteine-type deubiquitinase activity [GO:0004843]; K11-linked polyubiquitin modification-dependent protein binding [GO:0071795]; K48-linked deubiquitinase activity [GO:1990380]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K6-linked polyubiquitin modification-dependent protein binding [GO:0071796]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]	nucleoplasm [GO:0005654]; cysteine-type carboxypeptidase activity [GO:0016807]; cysteine-type deubiquitinase activity [GO:0004843]; K11-linked polyubiquitin modification-dependent protein binding [GO:0071795]; K48-linked deubiquitinase activity [GO:1990380]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K6-linked polyubiquitin modification-dependent protein binding [GO:0071796]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; proteolysis [GO:0006508]	
Q8NBS3	reviewed	S4A11_HUMAN	Solute carrier family 4 member 11 (Sodium borate cotransporter 1) (NaBC1)	SLC4A11 BTR1	Homo sapiens (Human)	875	FUNCTION: Multifunctional transporter with an impact in cell morphology and differentiation. In the presence of borate B(OH)4(-), acts as a voltage-dependent electrogenic Na(+)-coupled B(OH)4(-) cotransporter controlling boron homeostasis (PubMed:15525507). At early stages of stem cell differentiation, participates in synergy with ITGA5-ITGB1 and ITGAV-ITGB3 integrins and BMPR1A to promote cell adhesion and contractility that drives differentiation toward osteogenic commitment while inhibiting adipogenesis (By similarity). In the absence of B(OH)4(-), acts as a Na(+)-coupled OH(-) or H(+) permeable channel with implications in cellular redox balance (PubMed:15525507, PubMed:28642546). Regulates the oxidative stress response in corneal endothelium by enhancing antioxidant defenses and protecting cells from reactive oxygen species (PubMed:28642546). In response to hypo-osmotic challenge, also acts as water permeable channel at the basolateral cell membrane of corneal endothelial cells and facilitates transendothelial fluid reabsorption in the aqueous humor (PubMed:31273259, PubMed:25007886, PubMed:23813972). In the presence of ammonia, acts as an electrogenic NH3/H(+) cotransporter and may play a role in ammonia transport and reabsorption in renal Henle's loop epithelium (PubMed:27581649). {ECO:0000250|UniProtKB:A2AJN7, ECO:0000269|PubMed:15525507, ECO:0000269|PubMed:23813972, ECO:0000269|PubMed:25007886, ECO:0000269|PubMed:27581649, ECO:0000269|PubMed:28642546, ECO:0000269|PubMed:31273259}.	MISCELLANEOUS: Isoforms 1 and 5 correspond to alternative translation start site of the same transcript. There is no evidence that isoform 1 is expressed in primary tissues. It is shown that it is not expressed in cornea, however it is strongly expressed upon transfection into HEK-293 cells. {ECO:0000269|PubMed:31273259}.	bicarbonate transport [GO:0015701]; borate transport [GO:0046713]; cellular hypotonic response [GO:0071476]; cellular response to oxidative stress [GO:0034599]; fluid transport [GO:0042044]; intracellular monoatomic cation homeostasis [GO:0030003]; monoatomic anion transport [GO:0006820]; monoatomic ion homeostasis [GO:0050801]; proton transmembrane transport [GO:1902600]; regulation of mesenchymal stem cell differentiation [GO:2000739]; regulation of mitochondrial membrane potential [GO:0051881]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]	active borate transmembrane transporter activity [GO:0046715]; bicarbonate transmembrane transporter activity [GO:0015106]; protein dimerization activity [GO:0046983]; proton channel activity [GO:0015252]; proton transmembrane transporter activity [GO:0015078]; sodium channel activity [GO:0005272]; solute:inorganic anion antiporter activity [GO:0005452]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]; water transmembrane transporter activity [GO:0005372]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; active borate transmembrane transporter activity [GO:0046715]; bicarbonate transmembrane transporter activity [GO:0015106]; protein dimerization activity [GO:0046983]; proton channel activity [GO:0015252]; proton transmembrane transporter activity [GO:0015078]; sodium channel activity [GO:0005272]; solute:inorganic anion antiporter activity [GO:0005452]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]; water transmembrane transporter activity [GO:0005372]; bicarbonate transport [GO:0015701]; borate transport [GO:0046713]; cellular hypotonic response [GO:0071476]; cellular response to oxidative stress [GO:0034599]; fluid transport [GO:0042044]; intracellular monoatomic cation homeostasis [GO:0030003]; monoatomic anion transport [GO:0006820]; monoatomic ion homeostasis [GO:0050801]; proton transmembrane transport [GO:1902600]; regulation of mesenchymal stem cell differentiation [GO:2000739]; regulation of mitochondrial membrane potential [GO:0051881]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18024964, ECO:0000269|PubMed:25007886}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:23813972}; Multi-pass membrane protein {ECO:0000255}.
Q8NBS9	reviewed	TXND5_HUMAN	Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46)	TXNDC5 TLP46 UNQ364/PRO700	Homo sapiens (Human)	432	FUNCTION: Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds. {ECO:0000250|UniProtKB:Q91W90}.		negative regulation of apoptotic process [GO:0043066]; protein folding [GO:0006457]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]	protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; negative regulation of apoptotic process [GO:0043066]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q91W90, ECO:0000255|PROSITE-ProRule:PRU10138}.
Q8NBT0	reviewed	POC1A_HUMAN	POC1 centriolar protein homolog A (Pix2) (Proteome of centriole protein 1A) (WD repeat-containing protein 51A)	POC1A WDR51A	Homo sapiens (Human)	407	FUNCTION: Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation. {ECO:0000269|PubMed:19109428, ECO:0000269|PubMed:23015594}.		cilium assembly [GO:0060271]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; spindle pole [GO:0000922]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; spindle pole [GO:0000922]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole. Note=Component of both mother and daughter centrioles.
Q8NBT2	reviewed	SPC24_HUMAN	Kinetochore protein Spc24 (hSpc24)	SPC24 SPBC24	Homo sapiens (Human)	197	FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:23085020}.		attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic spindle assembly checkpoint signaling [GO:0007094]	cytosol [GO:0005829]; kinetochore [GO:0000776]; Ndc80 complex [GO:0031262]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; kinetochore [GO:0000776]; Ndc80 complex [GO:0031262]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic spindle assembly checkpoint signaling [GO:0007094]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:15561729, ECO:0000269|PubMed:15961401, ECO:0000269|PubMed:15964272}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:15561729, ECO:0000269|PubMed:15961401, ECO:0000269|PubMed:15964272}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. {ECO:0000269|PubMed:14738735}.
Q8NBU5	reviewed	ATAD1_HUMAN	Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (hATAD1) (Thorase)	ATAD1 FNP001	Homo sapiens (Human)	361	FUNCTION: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). {ECO:0000250|UniProtKB:P28737, ECO:0000250|UniProtKB:Q9D5T0, ECO:0000269|PubMed:24843043}.		extraction of mislocalized protein from mitochondrial outer membrane [GO:0140570]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; positive regulation of receptor internalization [GO:0002092]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778]; postsynaptic membrane [GO:0045211]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; membrane protein dislocase activity [GO:0140567]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778]; postsynaptic membrane [GO:0045211]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; membrane protein dislocase activity [GO:0140567]; extraction of mislocalized protein from mitochondrial outer membrane [GO:0140570]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; positive regulation of receptor internalization [GO:0002092]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:24843043}; Single-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000269|PubMed:24843043}; Single-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9D5T0}; Single-pass membrane protein {ECO:0000255}.
Q8NBV8	reviewed	SYT8_HUMAN	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII)	SYT8	Homo sapiens (Human)	387	FUNCTION: Involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells. {ECO:0000250|UniProtKB:Q9R0N6}.		calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488]	acrosomal vesicle [GO:0001669]; axon [GO:0030424]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]	acrosomal vesicle [GO:0001669]; axon [GO:0030424]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9R0N6}.
Q8NBW4	reviewed	S38A9_HUMAN	Neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11)	SLC38A9 URLC11	Homo sapiens (Human)	561	FUNCTION: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels (PubMed:25567906, PubMed:25561175, PubMed:29053970). Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25567906, PubMed:29053970). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:25567906, PubMed:25561175). SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids (PubMed:25561175, PubMed:25567906). Acts as an arginine sensor (PubMed:25567906, PubMed:29053970, PubMed:31295473). Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation (PubMed:29053970, PubMed:31295473). However, the transport mechanism is not well defined and the role of sodium is not clear (PubMed:25561175, PubMed:31295473). Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC (PubMed:32868926). Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases (PubMed:28336668). Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency (PubMed:30181260). {ECO:0000269|PubMed:25561175, ECO:0000269|PubMed:25567906, ECO:0000269|PubMed:28336668, ECO:0000269|PubMed:29053970, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31295473, ECO:0000269|PubMed:32868926, ECO:0000305|PubMed:31295473}.		amino acid transmembrane transport [GO:0003333]; asparagine transport [GO:0006867]; cellular response to amino acid stimulus [GO:0071230]; glutamine transport [GO:0006868]; L-arginine transmembrane transport [GO:1903826]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]	FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]	amino acid transmembrane transporter activity [GO:0015171]; arginine binding [GO:0034618]; cholesterol binding [GO:0015485]; guanyl-nucleotide exchange factor activity [GO:0005085]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-asparagine transmembrane transporter activity [GO:0015182]; L-glutamine transmembrane transporter activity [GO:0015186]; L-leucine transmembrane transporter activity [GO:0015190]; metal ion binding [GO:0046872]; sterol sensor activity [GO:0032935]	FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; amino acid transmembrane transporter activity [GO:0015171]; arginine binding [GO:0034618]; cholesterol binding [GO:0015485]; guanyl-nucleotide exchange factor activity [GO:0005085]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-asparagine transmembrane transporter activity [GO:0015182]; L-glutamine transmembrane transporter activity [GO:0015186]; L-leucine transmembrane transporter activity [GO:0015190]; metal ion binding [GO:0046872]; sterol sensor activity [GO:0032935]; amino acid transmembrane transport [GO:0003333]; asparagine transport [GO:0006867]; cellular response to amino acid stimulus [GO:0071230]; glutamine transport [GO:0006868]; L-arginine transmembrane transport [GO:1903826]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:25561175, ECO:0000269|PubMed:25567906, ECO:0000269|PubMed:29053970, ECO:0000269|PubMed:30956113}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q08BA4}. Late endosome membrane {ECO:0000269|PubMed:25561175}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q08BA4}.
Q8NBZ0	reviewed	IN80E_HUMAN	INO80 complex subunit E (Coiled-coil domain-containing protein 95)	INO80E CCDC95	Homo sapiens (Human)	244	FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.		chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	Ino80 complex [GO:0031011]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		Ino80 complex [GO:0031011]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18922472}.
Q8NBZ7	reviewed	UXS1_HUMAN	UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1) (hUXS) (hUXS1)	UXS1 UNQ2538/PRO6079	Homo sapiens (Human)	420	FUNCTION: Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose (PubMed:23656592, PubMed:22810237, PubMed:25521717). Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (PubMed:23656592, PubMed:22810237, PubMed:25521717). {ECO:0000269|PubMed:22810237, ECO:0000269|PubMed:23656592, ECO:0000269|PubMed:25521717}.		D-xylose metabolic process [GO:0042732]; UDP-D-xylose biosynthetic process [GO:0033320]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi cisterna membrane [GO:0032580]	identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]; UDP-glucuronate decarboxylase activity [GO:0048040]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi cisterna membrane [GO:0032580]; identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]; UDP-glucuronate decarboxylase activity [GO:0048040]; D-xylose metabolic process [GO:0042732]; UDP-D-xylose biosynthetic process [GO:0033320]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q5PQX0}; Single-pass type II membrane protein {ECO:0000305}.
Q8NC01	reviewed	CLC1A_HUMAN	C-type lectin domain family 1 member A (C-type lectin-like receptor 1) (CLEC-1)	CLEC1A CLEC1 UNQ569/PRO1131	Homo sapiens (Human)	280			cell surface receptor signaling pathway [GO:0007166]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8NC06	reviewed	ACBD4_HUMAN	Acyl-CoA-binding domain-containing protein 4	ACBD4 HMFT0700	Homo sapiens (Human)	268	FUNCTION: Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.		fatty acid metabolic process [GO:0006631]	cytoplasm [GO:0005737]	fatty-acyl-CoA binding [GO:0000062]	cytoplasm [GO:0005737]; fatty-acyl-CoA binding [GO:0000062]; fatty acid metabolic process [GO:0006631]	
Q8NC24	reviewed	RELL2_HUMAN	RELT-like protein 2	RELL2 C5orf16 UNQ9423/PRO34565	Homo sapiens (Human)	303	FUNCTION: Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}.		positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of p38MAPK cascade [GO:1900745]	basement membrane [GO:0005604]; plasma membrane [GO:0005886]	collagen binding [GO:0005518]	basement membrane [GO:0005604]; plasma membrane [GO:0005886]; collagen binding [GO:0005518]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of p38MAPK cascade [GO:1900745]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16389068}; Single-pass membrane protein {ECO:0000269|PubMed:16389068}.
Q8NC26	reviewed	ZN114_HUMAN	Zinc finger protein 114	ZNF114	Homo sapiens (Human)	417	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NC42	reviewed	RN149_HUMAN	E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149)	RNF149 DNAPTP2	Homo sapiens (Human)	400	FUNCTION: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation. {ECO:0000269|PubMed:22628551}.		cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of MAPK cascade [GO:0043409]; protein ubiquitination [GO:0016567]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; membrane [GO:0016020]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of MAPK cascade [GO:0043409]; protein ubiquitination [GO:0016567]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8NC44	reviewed	RETR2_HUMAN	Reticulophagy regulator 2	RETREG2 C2orf17 FAM134A MAG2	Homo sapiens (Human)	543	FUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}.		collagen catabolic process [GO:0030574]; endoplasmic reticulum organization [GO:0007029]; reticulophagy [GO:0061709]	endoplasmic reticulum membrane [GO:0005789]	endoplasmic reticulum-autophagosome adaptor activity [GO:0140506]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-autophagosome adaptor activity [GO:0140506]; collagen catabolic process [GO:0030574]; endoplasmic reticulum organization [GO:0007029]; reticulophagy [GO:0061709]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:34338405}; Multi-pass membrane protein {ECO:0000255}.
Q8NC51	reviewed	SERB1_HUMAN	SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein)	SERBP1 PAIRBP1 CGI-55	Homo sapiens (Human)	408	FUNCTION: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to a competing acceptor splice site. {ECO:0000305}.	negative regulation of translation [GO:0017148]; PML body organization [GO:0030578]; regulation of mRNA stability [GO:0043488]; ribosome hibernation [GO:0141014]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	cadherin binding [GO:0045296]; mRNA 3'-UTR binding [GO:0003730]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SUMO binding [GO:0032183]; translation elongation factor binding [GO:0061770]; translation repressor activity [GO:0030371]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; cadherin binding [GO:0045296]; mRNA 3'-UTR binding [GO:0003730]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SUMO binding [GO:0032183]; translation elongation factor binding [GO:0061770]; translation repressor activity [GO:0030371]; negative regulation of translation [GO:0017148]; PML body organization [GO:0030578]; regulation of mRNA stability [GO:0043488]; ribosome hibernation [GO:0141014]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12505151, ECO:0000269|PubMed:28695742}. Nucleus {ECO:0000269|PubMed:12505151, ECO:0000269|PubMed:28695742}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12505151}.
Q8NC56	reviewed	LEMD2_HUMAN	LEM domain-containing protein 2 (hLEM2)	LEMD2	Homo sapiens (Human)	503	FUNCTION: Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). {ECO:0000250|UniProtKB:Q6DVA0, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}.		heart formation [GO:0060914]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; neurogenesis [GO:0022008]; nuclear envelope organization [GO:0006998]; protein localization to chromatin [GO:0071168]; skeletal muscle cell differentiation [GO:0035914]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; spindle [GO:0005819]		cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; spindle [GO:0005819]; heart formation [GO:0060914]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; neurogenesis [GO:0022008]; nuclear envelope organization [GO:0006998]; protein localization to chromatin [GO:0071168]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:30905398, ECO:0000269|PubMed:32494070}; Multi-pass membrane protein {ECO:0000269|PubMed:16339967}. Nucleus envelope {ECO:0000269|PubMed:28242692}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:32494070}. Note=Lamina-associated protein residing in the inner nuclear membrane (INM) of the nuclear envelope (NE) (PubMed:16339967). The localization to the INM is dependent on LMNA (PubMed:16339967). Evenly distributed around the NE during interphase (PubMed:16339967). During metaphase, found in a reticular network (PubMed:28242692). Recruited to the reforming NE on chromatin disks in early anaphase (PubMed:28242692). In late anaphase, concentrates at the NE core proximal to spindle microtubules, and then broadening to a distributed nuclear rim pattern (PubMed:28242692, PubMed:32494070). {ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}.
Q8NC60	reviewed	NOA1_HUMAN	Nitric oxide-associated protein 1	NOA1 C4orf14	Homo sapiens (Human)	698	FUNCTION: Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP. {ECO:0000269|PubMed:19103604}.		apoptotic process [GO:0006915]; mitochondrial ribosome assembly [GO:0061668]; mitochondrion organization [GO:0007005]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GTP binding [GO:0005525]; RNA binding [GO:0003723]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; GTP binding [GO:0005525]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; mitochondrial ribosome assembly [GO:0061668]; mitochondrion organization [GO:0007005]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:19103604}; Peripheral membrane protein {ECO:0000269|PubMed:19103604}; Matrix side {ECO:0000269|PubMed:19103604}.
Q8NC67	reviewed	NETO2_HUMAN	Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2)	NETO2 BTCL2 UNQ1926/PRO4401	Homo sapiens (Human)	525	FUNCTION: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity). {ECO:0000250}.		neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]	glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]	ionotropic glutamate receptor binding [GO:0035255]	glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; ionotropic glutamate receptor binding [GO:0035255]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8NC69	reviewed	KCTD6_HUMAN	BTB/POZ domain-containing protein KCTD6 (KCASH3 protein) (Potassium channel tetramerization domain-containing protein 6)	KCTD6	Homo sapiens (Human)	237	FUNCTION: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887). {ECO:0000269|PubMed:21472142, ECO:0000269|PubMed:22573887}.		negative regulation of smoothened signaling pathway [GO:0045879]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; M band [GO:0031430]	ankyrin binding [GO:0030506]; cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; M band [GO:0031430]; ankyrin binding [GO:0030506]; cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]; negative regulation of smoothened signaling pathway [GO:0045879]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:22573887}. Note=Colocalizes with ANK1 isoform Mu17 at the M line in differentiated skeletal muscle cells and heart. {ECO:0000269|PubMed:22573887}.
Q8NCA5	reviewed	FA98A_HUMAN	Protein FAM98A	FAM98A	Homo sapiens (Human)	518	FUNCTION: Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). {ECO:0000250|UniProtKB:Q3TJZ6, ECO:0000269|PubMed:28040436}.		lysosome localization [GO:0032418]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of ruffle assembly [GO:1900029]; protein methylation [GO:0006479]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669]	protein methyltransferase activity [GO:0008276]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669]; protein methyltransferase activity [GO:0008276]; RNA binding [GO:0003723]; lysosome localization [GO:0032418]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of ruffle assembly [GO:1900029]; protein methylation [GO:0006479]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	
Q8NCB2	reviewed	CAMKV_HUMAN	CaM kinase-like vesicle-associated protein	CAMKV	Homo sapiens (Human)	501	FUNCTION: Does not appear to have detectable kinase activity.		modulation of chemical synaptic transmission [GO:0050804]; regulation of modification of postsynaptic structure [GO:0099159]	cytoplasmic vesicle membrane [GO:0030659]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]	cytoplasmic vesicle membrane [GO:0030659]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; modulation of chemical synaptic transmission [GO:0050804]; regulation of modification of postsynaptic structure [GO:0099159]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. May be associated with vesicular structures (By similarity). {ECO:0000250}.
Q8NCC3	reviewed	PAG15_HUMAN	Phospholipase A2 group XV (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A and acyltransferase) (EC 2.3.1.-, EC 3.1.1.32, EC 3.1.1.4) (Lysosomal phospholipase A2) (LPLA2)	PLA2G15 LYPLA3 UNQ341/PRO540	Homo sapiens (Human)	412	FUNCTION: Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:10092508, PubMed:11790796, PubMed:20410020, PubMed:23958596, PubMed:29724779, PubMed:25727495). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:10092508, PubMed:11790796, PubMed:20410020, PubMed:23958596, PubMed:29724779, PubMed:25727495). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines (PubMed:29724779). Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (By similarity). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (PubMed:29724779). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress (PubMed:30830753). Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (By similarity). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (PubMed:10092508). {ECO:0000250|UniProtKB:Q8VEB4, ECO:0000269|PubMed:10092508, ECO:0000269|PubMed:11790796, ECO:0000269|PubMed:20410020, ECO:0000269|PubMed:23958596, ECO:0000269|PubMed:25727495, ECO:0000269|PubMed:29724779, ECO:0000269|PubMed:30830753}.		ceramide metabolic process [GO:0006672]; diacylglycerol biosynthetic process [GO:0006651]; fatty acid catabolic process [GO:0009062]; glycerophospholipid metabolic process [GO:0006650]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine catabolic process [GO:0046338]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; acylglycerol O-acyltransferase activity [GO:0016411]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; O-acyltransferase activity [GO:0008374]; phosphatidyl phospholipase B activity [GO:0102545]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipid binding [GO:0005543]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; acylglycerol O-acyltransferase activity [GO:0016411]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; O-acyltransferase activity [GO:0008374]; phosphatidyl phospholipase B activity [GO:0102545]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipid binding [GO:0005543]; zinc ion binding [GO:0008270]; ceramide metabolic process [GO:0006672]; diacylglycerol biosynthetic process [GO:0006651]; fatty acid catabolic process [GO:0009062]; glycerophospholipid metabolic process [GO:0006650]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine catabolic process [GO:0046338]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:23958596}. Secreted {ECO:0000269|PubMed:10092508, ECO:0000269|PubMed:20410020}. Membrane {ECO:0000269|PubMed:25727495}; Peripheral membrane protein {ECO:0000269|PubMed:25727495}.
Q8NCC5	reviewed	SPX3_HUMAN	Sugar phosphate exchanger 3 (Solute carrier family 37 member 3)	SLC37A3 SPX3	Homo sapiens (Human)	494	FUNCTION: Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity (PubMed:21949678). In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899). {ECO:0000269|PubMed:21949678, ECO:0000269|PubMed:29745899}.		carbohydrate transport [GO:0008643]; xenobiotic transmembrane transport [GO:0006855]	endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]	xenobiotic transmembrane transporter activity [GO:0042910]	endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; xenobiotic transmembrane transporter activity [GO:0042910]; carbohydrate transport [GO:0008643]; xenobiotic transmembrane transport [GO:0006855]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21949678}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:29745899}; Multi-pass membrane protein {ECO:0000255}.
Q8NCD3	reviewed	HJURP_HUMAN	Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9)	HJURP FAKTS FLEG1 URLC9	Homo sapiens (Human)	748	FUNCTION: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}.		CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; regulation of DNA binding [GO:0051101]; regulation of protein-containing complex assembly [GO:0043254]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; histone binding [GO:0042393]; identical protein binding [GO:0042802]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; regulation of DNA binding [GO:0051101]; regulation of protein-containing complex assembly [GO:0043254]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
Q8NCE0	reviewed	SEN2_HUMAN	tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)	TSEN2 SEN2	Homo sapiens (Human)	465	FUNCTION: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity. {ECO:0000269|PubMed:15109492}.		mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]; tRNA-type intron splice site recognition and cleavage [GO:0000379]	centrosome [GO:0005813]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214]	lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; tRNA-intron endonuclease activity [GO:0000213]	centrosome [GO:0005813]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214]; lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; tRNA-intron endonuclease activity [GO:0000213]; mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]; tRNA-type intron splice site recognition and cleavage [GO:0000379]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15109492}. Nucleus, nucleolus {ECO:0000269|PubMed:15109492}. Note=May be transiently localized in the nucleolus.
Q8NCE2	reviewed	MTMRE_HUMAN	Myotubularin-related protein 14 (EC 3.1.3.-) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (hJumpy)	MTMR14 C3orf29	Homo sapiens (Human)	650	FUNCTION: Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. {ECO:0000269|PubMed:17008356}.		dephosphorylation [GO:0016311]; macroautophagy [GO:0016236]; phosphatidylinositol biosynthetic process [GO:0006661]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; ruffle [GO:0001726]	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; ruffle [GO:0001726]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein serine/threonine phosphatase activity [GO:0004722]; dephosphorylation [GO:0016311]; macroautophagy [GO:0016236]; phosphatidylinositol biosynthetic process [GO:0006661]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17008356}. Note=Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
Q8NCF5	reviewed	NF2IP_HUMAN	NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein)	NFATC2IP NIP45	Homo sapiens (Human)	419	FUNCTION: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. {ECO:0000250}.
Q8NCG5	reviewed	CHST4_HUMAN	Carbohydrate sulfotransferase 4 (EC 2.8.2.-) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3) (GST-3) (High endothelial cells N-acetylglucosamine 6-O-sulfotransferase) (HEC-GlcNAc6ST) (L-selectin ligand sulfotransferase) (LSST) (N-acetylglucosamine 6-O-sulfotransferase 2) (GlcNAc6ST-2) (Gn6st-2)	CHST4	Homo sapiens (Human)	386	FUNCTION: Sulfotransferase involved in SELL/L-selectin ligand biosynthesis pathway. Catalyzes the transfer of the sulfate group from 3'-phospho-5'-adenylyl sulfate (PAPS) onto the hydroxyl group at C-6 position of the non-reducing N-acetylglucosamine (GlcNAc) residue within O-linked mucin-type glycans. Contributes to generate sialyl 6-sulfo Lewis X determinant (also known as MECA-79 epitope) for SELL recognition, a prerequisite for continuous lymphocyte homing into peripheral lymph nodes and antigen immune surveillance (PubMed:11439191, PubMed:12107080, PubMed:10330415, PubMed:11726653). Transfers the sulfate group primarily on core 2 GlcNAcbeta1-6(Galbeta1-3)GalNAcalphaSer/Thr and extended core 1 GlcNAcbeta1-3Galbeta1-3GalNAcalphaSer/Thr based O-linked glycans on CD34 and GLYCAM1 peripheral node addressins (PNAds) expressed on the lumenal side of high endothelial venules (HEVs) (PubMed:11439191). The recognition of PNAds by SELL initiates a multistep process comprising tethering and rolling of blood lymphocytes on HEVs against the blood flow, followed by chemokine signaling, integrin-mediated lymphocyte adhesion onto endothelial cells and lymphocyte transendothelial migration. Modulates rolling velocity and differential T and B lymphocyte recruitment into peripheral lymph nodes, with a major role in B lymphocyte homing. Might be redundant in sulfation of MADCAM1 and lymphocyte trafficking to mesenteric lymph nodes (By similarity). Can also sulfonate core 3 GlcNAcbeta1-3GalNAc-R based glycans as well as GlcNAcbeta1-3Galbeta1-Glc, GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharides, which might be ectopically expressed during tumorigenesis (PubMed:12107080, PubMed:11439191, PubMed:11726653). {ECO:0000250|UniProtKB:Q9R1I1, ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:11439191, ECO:0000269|PubMed:11726653, ECO:0000269|PubMed:12107080}.	MISCELLANEOUS: May serve as an anti-inflammatory target.	carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; immune response [GO:0006955]; inflammatory response [GO:0006954]; N-acetylglucosamine metabolic process [GO:0006044]; O-glycan processing [GO:0016266]; positive regulation of leukocyte tethering or rolling [GO:1903238]; protein sulfation [GO:0006477]; sulfur compound metabolic process [GO:0006790]	Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146]; carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; immune response [GO:0006955]; inflammatory response [GO:0006954]; N-acetylglucosamine metabolic process [GO:0006044]; O-glycan processing [GO:0016266]; positive regulation of leukocyte tethering or rolling [GO:1903238]; protein sulfation [GO:0006477]; sulfur compound metabolic process [GO:0006790]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12855678}; Single-pass type II membrane protein {ECO:0000269|PubMed:12855678}.
Q8NCG7	reviewed	DGLB_HUMAN	Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)	DAGLB	Homo sapiens (Human)	672	FUNCTION: Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). {ECO:0000250|UniProtKB:Q91WC9, ECO:0000269|PubMed:14610053}.		arachidonic acid metabolic process [GO:0019369]; diacylglycerol catabolic process [GO:0046340]; neuroblast proliferation [GO:0007405]; neurogenesis [GO:0022008]; neurotransmitter biosynthetic process [GO:0042136]; positive regulation of triglyceride catabolic process [GO:0010898]; prostaglandin biosynthetic process [GO:0001516]; regulation of inflammatory response [GO:0050727]	lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	acylglycerol lipase activity [GO:0047372]; lipase activity [GO:0016298]; metal ion binding [GO:0046872]; triglyceride lipase activity [GO:0004806]	lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; acylglycerol lipase activity [GO:0047372]; lipase activity [GO:0016298]; metal ion binding [GO:0046872]; triglyceride lipase activity [GO:0004806]; arachidonic acid metabolic process [GO:0019369]; diacylglycerol catabolic process [GO:0046340]; neuroblast proliferation [GO:0007405]; neurogenesis [GO:0022008]; neurotransmitter biosynthetic process [GO:0042136]; positive regulation of triglyceride catabolic process [GO:0010898]; prostaglandin biosynthetic process [GO:0001516]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14610053}; Multi-pass membrane protein {ECO:0000255}.
Q8NCH0	reviewed	CHSTE_HUMAN	Carbohydrate sulfotransferase 14 (EC 2.8.2.35) (Dermatan 4-sulfotransferase 1) (D4ST-1) (hD4ST1)	CHST14 D4ST1 UNQ1925/PRO4400	Homo sapiens (Human)	376	FUNCTION: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development. {ECO:0000269|PubMed:19661164}.		dermatan sulfate biosynthetic process [GO:0030208]; dermatan sulfate proteoglycan metabolic process [GO:0050655]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; phosphate ion binding [GO:0042301]; sulfotransferase activity [GO:0008146]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; phosphate ion binding [GO:0042301]; sulfotransferase activity [GO:0008146]; dermatan sulfate biosynthetic process [GO:0030208]; dermatan sulfate proteoglycan metabolic process [GO:0050655]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q8NCK7	reviewed	MOT11_HUMAN	Monocarboxylate transporter 11 (MCT 11) (Solute carrier family 16 member 11)	SLC16A11 MCT11	Homo sapiens (Human)	471	FUNCTION: Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane (PubMed:28666119). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345). {ECO:0000269|PubMed:24390345, ECO:0000269|PubMed:28666119}.		lipid metabolic process [GO:0006629]; monocarboxylic acid transport [GO:0015718]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	monocarboxylic acid transmembrane transporter activity [GO:0008028]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293]; lipid metabolic process [GO:0006629]; monocarboxylic acid transport [GO:0015718]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24390345}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:28666119}; Multi-pass membrane protein {ECO:0000255}.
Q8NCL4	reviewed	GALT6_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 6 (EC 2.4.1.41) (Polypeptide GalNAc transferase 6) (GalNAc-T6) (pp-GaNTase 6) (Protein-UDP acetylgalactosaminyltransferase 6) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6)	GALNT6	Homo sapiens (Human)	622	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:10464263, PubMed:31932717). May participate in synthesis of oncofetal fibronectin (PubMed:10464263). Has activity toward MUC1A, MUC2, EA2 and fibronectin peptides (PubMed:10464263). Glycosylates FGF23 (PubMed:31932717). {ECO:0000269|PubMed:10464263, ECO:0000269|PubMed:31932717}.		O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via threonine [GO:0018243]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via threonine [GO:0018243]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q14435}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q14435}.
Q8NCM2	reviewed	KCNH5_HUMAN	Potassium voltage-gated channel subfamily H member 5 (Ether-a-go-go potassium channel 2) (hEAG2) (Voltage-gated potassium channel subunit Kv10.2)	KCNH5 EAG2	Homo sapiens (Human)	988	FUNCTION: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.		potassium ion transmembrane transport [GO:0071805]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]; protein-containing complex binding [GO:0044877]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; protein-containing complex binding [GO:0044877]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q8NCM8	reviewed	DYHC2_HUMAN	Cytoplasmic dynein 2 heavy chain 1 (Cytoplasmic dynein 2 heavy chain) (Dynein cytoplasmic heavy chain 2) (Dynein heavy chain 11) (hDHC11) (Dynein heavy chain isotype 1B)	DYNC2H1 DHC1B DHC2 DNCH2 DYH1B KIAA1997	Homo sapiens (Human)	4307	FUNCTION: May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). {ECO:0000250}.		cilium movement involved in cell motility [GO:0060294]; coronary vasculature development [GO:0060976]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; forebrain development [GO:0030900]; Golgi organization [GO:0007030]; intraciliary retrograde transport [GO:0035721]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to cilium [GO:0061512]; protein processing [GO:0016485]; spinal cord motor neuron differentiation [GO:0021522]	9+2 motile cilium [GO:0097729]; apical part of cell [GO:0045177]; axoneme [GO:0005930]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasmic dynein complex [GO:0005868]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; apical part of cell [GO:0045177]; axoneme [GO:0005930]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasmic dynein complex [GO:0005868]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; cilium movement involved in cell motility [GO:0060294]; coronary vasculature development [GO:0060976]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; forebrain development [GO:0030900]; Golgi organization [GO:0007030]; intraciliary retrograde transport [GO:0035721]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to cilium [GO:0061512]; protein processing [GO:0016485]; spinal cord motor neuron differentiation [GO:0021522]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9JJ79}. Cell membrane {ECO:0000250|UniProtKB:Q45VK7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q45VK7}. Cytoplasm {ECO:0000250|UniProtKB:Q9JJ79}. Note=Localizes to the apical cytoplasm (By similarity). According to PubMed:8666668, it localizes to Golgi apparatus, cytoplasmic vesicle and endoplasmic reticulum (PubMed:8666668). {ECO:0000250|UniProtKB:Q9JJ79, ECO:0000269|PubMed:8666668}.
Q8NCN4	reviewed	RN169_HUMAN	E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169)	RNF169 KIAA1991	Homo sapiens (Human)	708	FUNCTION: Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}.		DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair [GO:2000780]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; ubiquitin modification-dependent histone binding [GO:0061649]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; ubiquitin modification-dependent histone binding [GO:0061649]; ubiquitin-protein transferase activity [GO:0004842]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair [GO:2000780]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. Nucleus, nucleoplasm {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833}. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products. {ECO:0000269|PubMed:30104380}.
Q8NCP5	reviewed	ZBT44_HUMAN	Zinc finger and BTB domain-containing protein 44 (BTB/POZ domain-containing protein 15) (Zinc finger protein 851)	ZBTB44 BTBD15 ZNF851	Homo sapiens (Human)	570	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.			nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8NCR0	reviewed	B3GL2_HUMAN	UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (Beta-1,3-GalNAc-T2) (EC 2.4.1.313) (Beta-1,3-N-acetylgalactosaminyltransferase II)	B3GALNT2	Homo sapiens (Human)	500	FUNCTION: Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. {ECO:0000269|PubMed:14724282, ECO:0000269|PubMed:23453667, ECO:0000269|PubMed:23929950}.		protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	acetylgalactosaminyltransferase activity [GO:0008376]; UDP-glycosyltransferase activity [GO:0008194]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; acetylgalactosaminyltransferase activity [GO:0008376]; UDP-glycosyltransferase activity [GO:0008194]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:23453667}.
Q8NCR6	reviewed	SMIP6_HUMAN	Sperm microtubule inner protein 6 (Ciliated bronchial epithelial protein 1) (Spermatid-specific manchette-related protein 1) (Testis development protein NYD-SP22)	SPMIP6 C9orf24 CBE1 SMRP1	Homo sapiens (Human)	262	FUNCTION: May participate in intramanchette transport and midpiece formation of the sperm tail. May play a potential role in somatic cell proliferation. {ECO:0000250|UniProtKB:Q2MH31}.		cell differentiation [GO:0030154]; protein-containing complex assembly [GO:0065003]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; manchette [GO:0002177]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sperm midpiece [GO:0097225]	alpha-tubulin binding [GO:0043014]	cytosol [GO:0005829]; manchette [GO:0002177]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sperm midpiece [GO:0097225]; alpha-tubulin binding [GO:0043014]; cell differentiation [GO:0030154]; protein-containing complex assembly [GO:0065003]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2MH31}. Nucleus {ECO:0000269|PubMed:15242845}. Cytoplasm {ECO:0000269|PubMed:15242845}. Mitochondrion {ECO:0000250|UniProtKB:Q2MH31}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:28601408}. Note=During spermatid elongation (step 10), localizes along the length of the manchette and later during the elongation process only at the distal ends of spermatid manchette (step 12). In late elongated spermatids (step 16), in the final steps of spermiogenesis, localization is restricted to the midpiece of the flagellum. Localizes at the contractile ring in dividing cells (By similarity). Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a number of cell lines (PubMed:15242845). {ECO:0000250|UniProtKB:Q2MH31, ECO:0000269|PubMed:15242845}.
Q8NCS7	reviewed	CTL5_HUMAN	Choline transporter-like protein 5 (Solute carrier family 44 member 5)	SLC44A5 CTL5	Homo sapiens (Human)	719	FUNCTION: Choline/H+ antiporter. {ECO:0000305|PubMed:23651124}.		choline transport [GO:0015871]; phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085]	membrane [GO:0016020]; plasma membrane [GO:0005886]	antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; transmembrane transporter activity [GO:0022857]; choline transport [GO:0015871]; phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:23651124}; Multi-pass membrane protein {ECO:0000255}.
Q8NCT1	reviewed	ARRD4_HUMAN	Arrestin domain-containing protein 4	ARRDC4	Homo sapiens (Human)	418	FUNCTION: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake (PubMed:19605364). Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 (PubMed:28594402). {ECO:0000250|UniProtKB:A0A0B4J1F4, ECO:0000269|PubMed:19605364, ECO:0000269|PubMed:28594402, ECO:0000305}.		extracellular vesicle biogenesis [GO:0140112]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular vesicle [GO:1903561]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular vesicle [GO:1903561]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; extracellular vesicle biogenesis [GO:0140112]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:23208550}. Cell membrane {ECO:0000269|PubMed:23208550, ECO:0000269|PubMed:23236378}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:23236378}. Note=Also found in extracellular vesicles different from exosomes. {ECO:0000250|UniProtKB:A0A0B4J1F4}.
Q8NCU7	reviewed	C2C4A_HUMAN	C2 calcium-dependent domain-containing protein 4A (Nuclear-localized factor 1) (Protein FAM148A)	C2CD4A FAM148A NLF1	Homo sapiens (Human)	369	FUNCTION: May be involved in inflammatory process. May regulate cell architecture and adhesion. {ECO:0000269|PubMed:15527968}.		positive regulation of acute inflammatory response [GO:0002675]; regulation of cell adhesion [GO:0030155]; regulation of vascular permeability involved in acute inflammatory response [GO:0002528]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; positive regulation of acute inflammatory response [GO:0002675]; regulation of cell adhesion [GO:0030155]; regulation of vascular permeability involved in acute inflammatory response [GO:0002528]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15527968}.
Q8NCU8	reviewed	MTLN_HUMAN	Mitoregulin (Micropeptide in mitochondria) (Micropeptide regulator of beta-oxidation) (Small integral membrane protein 37) (lncRNA-encoded micropeptide)	MTLN LEMP LINC00116 MOXI MPM NCRNA00116 SMIM37	Homo sapiens (Human)	56	FUNCTION: Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential while decreasing mitochondrial reactive oxygen species (PubMed:29949756). Increases mitochondrial respiration rate (PubMed:29949756). Increased mitochondrial respiratory activity promotes myogenic differentiation which facilitates muscle growth and regeneration (By similarity). Increases mitochondrial calcium retention capacity (PubMed:29949756). Plays a role in maintenance of cellular lipid composition through its interaction with cytochrome b5 reductase CYB5R3 which is required for mitochondrial respiratory complex I activity (By similarity). Interacts with the mitochondrial trifunctional enzyme complex (MTE) and enhances fatty acid beta-oxidation (PubMed:32243843). Not required for MTE formation or stability (By similarity). Modulates triglyceride clearance in adipocytes through its role in regulating fatty acid beta-oxidation and lipolysis (PubMed:32243843). {ECO:0000250|UniProtKB:Q8BT35, ECO:0000269|PubMed:29949756, ECO:0000269|PubMed:32243843}.		cellular lipid metabolic process [GO:0044255]; cellular respiration [GO:0045333]; fatty acid beta-oxidation [GO:0006635]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of sequestering of calcium ion [GO:0051284]; striated muscle cell differentiation [GO:0051146]; triglyceride homeostasis [GO:0070328]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; cellular lipid metabolic process [GO:0044255]; cellular respiration [GO:0045333]; fatty acid beta-oxidation [GO:0006635]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of sequestering of calcium ion [GO:0051284]; striated muscle cell differentiation [GO:0051146]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8BT35}; Single-pass membrane protein {ECO:0000305}. Note=Preferentially binds to cardiolipin relative to other common cell membrane lipids. {ECO:0000250|UniProtKB:Q8BT35}.
Q8NCW0	reviewed	KREM2_HUMAN	Kremen protein 2 (Dickkopf receptor 2) (Kringle domain-containing transmembrane protein 2) (Kringle-containing protein marking the eye and the nose)	KREMEN2 KRM2	Homo sapiens (Human)	462	FUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. {ECO:0000250|UniProtKB:Q8K1S7}.		limb development [GO:0060173]; negative regulation of ossification [GO:0030279]; Wnt signaling pathway [GO:0016055]	early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]		early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]; limb development [GO:0060173]; negative regulation of ossification [GO:0030279]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8NCW5	reviewed	NNRE_HUMAN	NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) (YjeF N-terminal domain-containing protein 1) (YjeF_N1)	NAXE AIBP APOA1BP YJEFN1	Homo sapiens (Human)	288	FUNCTION: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (PubMed:23719382). {ECO:0000255|HAMAP-Rule:MF_03159, ECO:0000269|PubMed:23719382, ECO:0000269|PubMed:27616477}.		lipid transport [GO:0006869]; membrane raft distribution [GO:0031580]; negative regulation of angiogenesis [GO:0016525]; nicotinamide nucleotide metabolic process [GO:0046496]; regulation of cholesterol efflux [GO:0010874]; sprouting angiogenesis [GO:0002040]	cell body [GO:0044297]; cilium [GO:0005929]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; NADHX epimerase activity [GO:0052856]; NADPHX epimerase activity [GO:0052857]; nucleotide binding [GO:0000166]	cell body [GO:0044297]; cilium [GO:0005929]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; NADHX epimerase activity [GO:0052856]; NADPHX epimerase activity [GO:0052857]; nucleotide binding [GO:0000166]; lipid transport [GO:0006869]; membrane raft distribution [GO:0031580]; negative regulation of angiogenesis [GO:0016525]; nicotinamide nucleotide metabolic process [GO:0046496]; regulation of cholesterol efflux [GO:0010874]; sprouting angiogenesis [GO:0002040]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03159}. Secreted {ECO:0000255|HAMAP-Rule:MF_03159, ECO:0000269|PubMed:11991719}. Note=In sperm, secretion gradually increases during capacitation. {ECO:0000255|HAMAP-Rule:MF_03159}.
Q8NCW6	reviewed	GLT11_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11)	GALNT11	Homo sapiens (Human)	608	FUNCTION: Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). {ECO:0000269|PubMed:11925450, ECO:0000269|PubMed:24226769}.		cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; Notch receptor processing [GO:0007220]; Notch signaling involved in heart development [GO:0061314]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via threonine [GO:0018243]; regulation of Notch signaling pathway [GO:0008593]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; Notch binding [GO:0005112]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; Notch binding [GO:0005112]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; Notch receptor processing [GO:0007220]; Notch signaling involved in heart development [GO:0061314]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via threonine [GO:0018243]; regulation of Notch signaling pathway [GO:0008593]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11925450}; Single-pass type II membrane protein {ECO:0000269|PubMed:11925450}.
Q8ND04	reviewed	SMG8_HUMAN	Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog)	SMG8 ABC2 C17orf71	Homo sapiens (Human)	991	FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. {ECO:0000269|PubMed:19417104}.		nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of protein kinase activity [GO:0045859]	cytosol [GO:0005829]		cytosol [GO:0005829]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of protein kinase activity [GO:0045859]	
Q8ND25	reviewed	ZNRF1_HUMAN	E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)	ZNRF1 NIN283	Homo sapiens (Human)	227	FUNCTION: E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation (PubMed:28593998, PubMed:33996800, PubMed:37158982). Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery (PubMed:33996800). Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production (PubMed:37158982). Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response (PubMed:28593998). {ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:28593998, ECO:0000269|PubMed:29626159, ECO:0000269|PubMed:33996800, ECO:0000269|PubMed:37158982, ECO:0000305|PubMed:14561866}.		positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]	SUBCELLULAR LOCATION: Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Associated with synaptic vesicle membranes in neurons.
Q8ND30	reviewed	LIPB2_HUMAN	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2)	PPFIBP2	Homo sapiens (Human)	876	FUNCTION: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}.		neuromuscular junction development [GO:0007528]	cytosol [GO:0005829]; extracellular space [GO:0005615]; presynaptic active zone [GO:0048786]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; extracellular space [GO:0005615]; presynaptic active zone [GO:0048786]; identical protein binding [GO:0042802]; neuromuscular junction development [GO:0007528]	
Q8ND56	reviewed	LS14A_HUMAN	Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A)	LSM14A C19orf13 FAM61A RAP55 RAP55A	Homo sapiens (Human)	463	FUNCTION: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}.		defense response to virus [GO:0051607]; mitotic spindle assembly [GO:0090307]; negative regulation of translation [GO:0017148]; P-body assembly [GO:0033962]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; RIG-I signaling pathway [GO:0039529]; stress granule assembly [GO:0034063]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]	double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; defense response to virus [GO:0051607]; mitotic spindle assembly [GO:0090307]; negative regulation of translation [GO:0017148]; P-body assembly [GO:0033962]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; RIG-I signaling pathway [GO:0039529]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:32354837}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26339800}. Cytoplasm, Stress granule {ECO:0000269|PubMed:16484376}.
Q8ND76	reviewed	CCNY_HUMAN	Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X)	CCNY C10orf9 CBCP1 CFP1	Homo sapiens (Human)	341	FUNCTION: Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}.		cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of autophagy [GO:0010508]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; regulation of canonical Wnt signaling pathway [GO:0060828]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasmic cyclin-dependent protein kinase holoenzyme complex [GO:0000308]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasmic cyclin-dependent protein kinase holoenzyme complex [GO:0000308]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901]; cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of autophagy [GO:0010508]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; regulation of canonical Wnt signaling pathway [GO:0060828]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}; Lipid-anchor {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}; Cytoplasmic side {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus.
Q8ND83	reviewed	SLAI1_HUMAN	SLAIN motif-containing protein 1	SLAIN1 C13orf32	Homo sapiens (Human)	568	FUNCTION: Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation. {ECO:0000269|PubMed:21646404}.		cytoplasmic microtubule organization [GO:0031122]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytoplasmic microtubule organization [GO:0031122]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21646404}. Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules. {ECO:0000269|PubMed:21646404}.
Q8ND90	reviewed	PNMA1_HUMAN	Paraneoplastic antigen Ma1 (37 kDa neuronal protein) (Neuron- and testis-specific protein 1)	PNMA1 MA1	Homo sapiens (Human)	353		MISCELLANEOUS: Antibodies against PNMA1 are present in sera from patients suffering of paraneoplastic neurological disorders.	inflammatory response to antigenic stimulus [GO:0002437]; positive regulation of apoptotic process [GO:0043065]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]		cytoplasm [GO:0005737]; nucleolus [GO:0005730]; inflammatory response to antigenic stimulus [GO:0002437]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10050892}. Note=In tumor cells, it is cytoplasmic.
Q8NDB2	reviewed	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats	BANK1	Homo sapiens (Human)	785	FUNCTION: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. {ECO:0000269|PubMed:11782428}.		B cell activation [GO:0042113]; B cell receptor signaling pathway [GO:0050853]; MAPK cascade [GO:0000165]; negative regulation of B cell activation [GO:0050869]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of translational initiation [GO:0045947]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; response to bacterium [GO:0009617]	perinuclear region of cytoplasm [GO:0048471]	phospholipase binding [GO:0043274]; protease binding [GO:0002020]; protein tyrosine kinase binding [GO:1990782]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]	perinuclear region of cytoplasm [GO:0048471]; phospholipase binding [GO:0043274]; protease binding [GO:0002020]; protein tyrosine kinase binding [GO:1990782]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; B cell activation [GO:0042113]; B cell receptor signaling pathway [GO:0050853]; MAPK cascade [GO:0000165]; negative regulation of B cell activation [GO:0050869]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of translational initiation [GO:0045947]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; response to bacterium [GO:0009617]	
Q8NDC0	reviewed	MISSL_HUMAN	MAPK-interacting and spindle-stabilizing protein-like (Mitogen-activated protein kinase 1-interacting protein 1-like)	MAPK1IP1L C14orf32	Homo sapiens (Human)	245							
Q8NDC4	reviewed	MORN4_HUMAN	MORN repeat-containing protein 4 (Protein 44050) (Retinophilin)	MORN4 C10orf83	Homo sapiens (Human)	146	FUNCTION: Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. {ECO:0000250|UniProtKB:Q6PGF2}.		response to axon injury [GO:0048678]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; filopodium tip [GO:0032433]; stereocilium tip [GO:0032426]		cell projection [GO:0042995]; cytoplasm [GO:0005737]; filopodium tip [GO:0032433]; stereocilium tip [GO:0032426]; response to axon injury [GO:0048678]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25822849}. Cell projection, filopodium tip {ECO:0000269|PubMed:25822849}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q6PGF2}. Note=Found in the cytoplasm in the absence of MYO3A and localizes at filopodial tips in the presence of MYO3A. {ECO:0000269|PubMed:25822849}.
Q8NDD1	reviewed	CA131_HUMAN	Uncharacterized protein C1orf131	C1orf131 cPERP-A	Homo sapiens (Human)	293	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Prevents helicase DHX37 to be recruited before post-A1 state. {ECO:0000269|PubMed:34516797}.		ribosomal small subunit biogenesis [GO:0042274]	chromosome [GO:0005694]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	chromosome [GO:0005694]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:20813266}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
Q8NDF8	reviewed	PAPD5_HUMAN	Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2)	TENT4B GLD4 PAPD5 TRF4-2 TUT3	Homo sapiens (Human)	572	FUNCTION: Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:28383716, ECO:0000269|PubMed:30026317}.		carbohydrate homeostasis [GO:0033500]; cell cycle [GO:0007049]; cell division [GO:0051301]; histone mRNA catabolic process [GO:0071044]; miRNA catabolic process [GO:0010587]; mRNA polyadenylation [GO:0006378]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; negative regulation of telomere maintenance via telomerase [GO:0032211]; polyadenylation-dependent ncRNA catabolic process [GO:0043634]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; rRNA processing [GO:0006364]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; TRAMP complex [GO:0031499]	DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; guanylyltransferase activity [GO:0070568]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; TRAMP complex [GO:0031499]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; guanylyltransferase activity [GO:0070568]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; carbohydrate homeostasis [GO:0033500]; cell cycle [GO:0007049]; cell division [GO:0051301]; histone mRNA catabolic process [GO:0071044]; miRNA catabolic process [GO:0010587]; mRNA polyadenylation [GO:0006378]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; negative regulation of telomere maintenance via telomerase [GO:0032211]; polyadenylation-dependent ncRNA catabolic process [GO:0043634]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334}. Nucleus, nucleolus {ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:23376078}. Cytoplasm {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:28383716}. Note=Predominantly expressed in the cytoplasm (PubMed:18172165).
Q8NDG6	reviewed	TDRD9_HUMAN	ATP-dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain-containing protein 9)	TDRD9 C14orf75	Homo sapiens (Human)	1382	FUNCTION: ATP-binding RNA helicase required during spermatogenesis (PubMed:28536242). Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4. {ECO:0000250|UniProtKB:Q14BI7, ECO:0000269|PubMed:28536242}.		cell differentiation [GO:0030154]; fertilization [GO:0009566]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; piRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141006]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; piP-body [GO:0071547]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; piP-body [GO:0071547]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; cell differentiation [GO:0030154]; fertilization [GO:0009566]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; piRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141006]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28536242}. Nucleus {ECO:0000250|UniProtKB:Q14BI7}. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies. {ECO:0000250|UniProtKB:Q14BI7}.
Q8NDH3	reviewed	PEPL1_HUMAN	Probable aminopeptidase NPEPL1 (EC 3.4.11.-) (Aminopeptidase-like 1)	NPEPL1 KIAA1974	Homo sapiens (Human)	523	FUNCTION: Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.		proteolysis [GO:0006508]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; peptidase activity [GO:0008233]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; peptidase activity [GO:0008233]; proteolysis [GO:0006508]	
Q8NDH6	reviewed	ICA1L_HUMAN	Islet cell autoantigen 1-like protein (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein)	ICA1L ALS2CR14 ALS2CR15	Homo sapiens (Human)	482			regulation of transport [GO:0051049]	Golgi apparatus [GO:0005794]	protein domain specific binding [GO:0019904]	Golgi apparatus [GO:0005794]; protein domain specific binding [GO:0019904]; regulation of transport [GO:0051049]	
Q8NDI1	reviewed	EHBP1_HUMAN	EH domain-binding protein 1	EHBP1 KIAA0903 NACSIN	Homo sapiens (Human)	1231	FUNCTION: May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}.		endocytosis [GO:0006897]; protein transport [GO:0015031]	cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; endocytosis [GO:0006897]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14676205}. Membrane {ECO:0000269|PubMed:14676205}. Endosome {ECO:0000305|PubMed:27552051}. Note=Mostly found in cytosol and plasma membrane.
Q8NDL9	reviewed	CBPC5_HUMAN	Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 5) (Protein deglutamylase CCP5)	AGBL5 CCP5	Homo sapiens (Human)	886	FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation. {ECO:0000250|UniProtKB:Q09M02}.		C-terminal protein deglutamylation [GO:0035609]; defense response to virus [GO:0051607]; protein branching point deglutamylation [GO:0035611]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]	metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]; C-terminal protein deglutamylation [GO:0035609]; defense response to virus [GO:0051607]; protein branching point deglutamylation [GO:0035611]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09M02}. Nucleus {ECO:0000269|PubMed:23085998}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23085998}. Midbody {ECO:0000269|PubMed:23085998}. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis. {ECO:0000250|UniProtKB:Q09M02, ECO:0000269|PubMed:23085998}.
Q8NDM7	reviewed	CFA43_HUMAN	Cilia- and flagella-associated protein 43 (WD repeat-containing protein 96)	CFAP43 C10orf79 WDR96	Homo sapiens (Human)	1665	FUNCTION: Flagellar protein involved in sperm flagellum axoneme organization and function (By similarity). Involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). {ECO:0000250|UniProtKB:E9Q7R9}.		brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197]; regulation of cilium beat frequency [GO:0003356]; sperm axoneme assembly [GO:0007288]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; extracellular region [GO:0005576]		9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; extracellular region [GO:0005576]; brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197]; regulation of cilium beat frequency [GO:0003356]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A8JAF2}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q57WH1}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:E9Q7R9}.
Q8NDN9	reviewed	RCBT1_HUMAN	RCC1 and BTB domain-containing protein 1 (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein) (Regulator of chromosome condensation and BTB domain-containing protein 1)	RCBTB1 CLLD7 E4.5	Homo sapiens (Human)	531	FUNCTION: May be involved in cell cycle regulation by chromatin remodeling. {ECO:0000269|PubMed:11306461}.		cell cycle [GO:0007049]; chromatin organization [GO:0006325]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; cell cycle [GO:0007049]; chromatin organization [GO:0006325]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NDP4	reviewed	ZN439_HUMAN	Zinc finger protein 439	ZNF439	Homo sapiens (Human)	499	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NDQ6	reviewed	ZN540_HUMAN	Zinc finger protein 540	ZNF540 Nbla10512	Homo sapiens (Human)	660	FUNCTION: May act as a transcriptional repressor. {ECO:0000269|PubMed:16815308}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of translation [GO:0017148]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; mRNA regulatory element binding translation repressor activity [GO:0000900]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; mRNA regulatory element binding translation repressor activity [GO:0000900]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of translation [GO:0017148]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16815308}. Cytoplasm {ECO:0000269|PubMed:16815308}.
Q8NDT2	reviewed	RB15B_HUMAN	Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B)	RBM15B OTT3	Homo sapiens (Human)	890	FUNCTION: RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}.		dosage compensation by inactivation of X chromosome [GO:0009048]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA methylation [GO:0001510]; RNA splicing [GO:0008380]	nuclear envelope [GO:0005635]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nuclear envelope [GO:0005635]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; dosage compensation by inactivation of X chromosome [GO:0009048]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA methylation [GO:0001510]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:16129689}. Nucleus speckle {ECO:0000269|PubMed:19586903}. Nucleus envelope {ECO:0000269|PubMed:19586903}. Note=Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli. {ECO:0000269|PubMed:16129689}.
Q8NDV1	reviewed	SIA7C_HUMAN	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (EC 2.4.3.7) (GalNAc alpha-2,6-sialyltransferase III) (ST6GalNAc III) (ST6GalNAcIII) (STY) (Sialyltransferase 7C) (SIAT7-C)	ST6GALNAC3 SIAT7C UNQ2787/PRO7177	Homo sapiens (Human)	305	FUNCTION: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:16169874, PubMed:17123352). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (PubMed:17123352). {ECO:0000250|UniProtKB:Q9QYJ1, ECO:0000269|PubMed:16169874, ECO:0000269|PubMed:17123352}.		ganglioside biosynthetic process [GO:0001574]; glycoprotein metabolic process [GO:0009100]; glycosphingolipid metabolic process [GO:0006687]; glycosylceramide metabolic process [GO:0006677]; oligosaccharide metabolic process [GO:0009311]; viral protein processing [GO:0019082]	Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity [GO:0047290]; sialyltransferase activity [GO:0008373]	Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity [GO:0047290]; sialyltransferase activity [GO:0008373]; ganglioside biosynthetic process [GO:0001574]; glycoprotein metabolic process [GO:0009100]; glycosphingolipid metabolic process [GO:0006687]; glycosylceramide metabolic process [GO:0006677]; oligosaccharide metabolic process [GO:0009311]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8NDV3	reviewed	SMC1B_HUMAN	Structural maintenance of chromosomes protein 1B (SMC protein 1B) (SMC-1-beta) (SMC-1B)	SMC1B SMC1L2	Homo sapiens (Human)	1235	FUNCTION: Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). {ECO:0000250}.		meiotic cell cycle [GO:0051321]; sister chromatid cohesion [GO:0007062]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; lateral element [GO:0000800]; meiotic cohesin complex [GO:0030893]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; lateral element [GO:0000800]; meiotic cohesin complex [GO:0030893]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; meiotic cell cycle [GO:0051321]; sister chromatid cohesion [GO:0007062]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q920F6}. Chromosome {ECO:0000250|UniProtKB:Q920F6}. Chromosome, centromere {ECO:0000250|UniProtKB:Q920F6}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity). {ECO:0000250|UniProtKB:Q920F6}.
Q8NDV7	reviewed	TNR6A_HUMAN	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa)	TNRC6A CAGH26 KIAA1460 TNRC6	Homo sapiens (Human)	1962	FUNCTION: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}.	MISCELLANEOUS: Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.	cellular response to starvation [GO:0009267]; endoderm development [GO:0007492]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RISC complex [GO:0016442]	RNA binding [GO:0003723]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RISC complex [GO:0016442]; RNA binding [GO:0003723]; cellular response to starvation [GO:0009267]; endoderm development [GO:0007492]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:11950943, ECO:0000269|PubMed:13130130, ECO:0000269|PubMed:15494374, ECO:0000269|PubMed:15908945, ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:18946079, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19324964}. Note=Mammalian P-bodies are also known as GW bodies (GWBs). {ECO:0000305}.
Q8NDW8	reviewed	TT21A_HUMAN	Tetratricopeptide repeat protein 21A (TPR repeat protein 21A) (Stress-inducible protein 2)	TTC21A STI2	Homo sapiens (Human)	1320	FUNCTION: Intraflagellar transport (IFT)-associated protein required for spermatogenesis (PubMed:30929735). Required for sperm flagellar formation and intraflagellar transport (PubMed:30929735). {ECO:0000269|PubMed:30929735}.		flagellated sperm motility [GO:0030317]; intraciliary retrograde transport [GO:0035721]; protein localization to cilium [GO:0061512]; spermatid development [GO:0007286]	cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]		cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]; flagellated sperm motility [GO:0030317]; intraciliary retrograde transport [GO:0035721]; protein localization to cilium [GO:0061512]; spermatid development [GO:0007286]	
Q8NDX1	reviewed	PSD4_HUMAN	PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein)	PSD4 EFA6B TIC	Homo sapiens (Human)	1056	FUNCTION: Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}.		regulation of ARF protein signal transduction [GO:0032012]	membrane [GO:0016020]; ruffle membrane [GO:0032587]	guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543]	membrane [GO:0016020]; ruffle membrane [GO:0032587]; guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543]; regulation of ARF protein signal transduction [GO:0032012]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:23603394}. Cell projection, ruffle membrane {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:23603394}. Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions (PubMed:23603394). Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures (PubMed:12082148). Recruited to membranes via phosphatidylinositol phosphate-binding (Probable). {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:23603394, ECO:0000305|PubMed:12082148}.
Q8NDX2	reviewed	VGLU3_HUMAN	Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8)	SLC17A8 VGLUT3	Homo sapiens (Human)	589	FUNCTION: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate (PubMed:33440152, PubMed:12151341). At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:12151341). The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:12151341). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (Probable). The symporter activity is electrogenic (PubMed:33440152). Moreover, operates synergistically with SLC18A3/VACHT under a constant H(+) gradient, thereby allowing striatal vesicular acetylcholine uptake (By similarity). {ECO:0000250|UniProtKB:Q7TSF2, ECO:0000269|PubMed:12151341, ECO:0000305|PubMed:33440152}.		cochlea development [GO:0090102]; L-glutamate import [GO:0051938]; L-glutamate transmembrane transport [GO:0015813]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; neural retina development [GO:0003407]; neurotransmitter loading into synaptic vesicle [GO:0098700]; phosphate ion homeostasis [GO:0055062]; positive regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051951]; regulation of acetylcholine uptake [GO:0051631]; regulation of synapse structure or activity [GO:0050803]; sensory perception of sound [GO:0007605]; sodium-dependent phosphate transport [GO:0044341]; synaptic transmission, glutamatergic [GO:0035249]	apical dendrite [GO:0097440]; axon terminus [GO:0043679]; basal dendrite [GO:0097441]; chloride channel complex [GO:0034707]; excitatory synapse [GO:0060076]; glial limiting end-foot [GO:0097451]; multivesicular body [GO:0005771]; pericellular basket [GO:1990030]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	chloride channel activity [GO:0005254]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamate uniporter activity [GO:0140788]; neurotransmitter transmembrane transporter activity [GO:0005326]; sodium:phosphate symporter activity [GO:0005436]	apical dendrite [GO:0097440]; axon terminus [GO:0043679]; basal dendrite [GO:0097441]; chloride channel complex [GO:0034707]; excitatory synapse [GO:0060076]; glial limiting end-foot [GO:0097451]; multivesicular body [GO:0005771]; pericellular basket [GO:1990030]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; chloride channel activity [GO:0005254]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamate uniporter activity [GO:0140788]; neurotransmitter transmembrane transporter activity [GO:0005326]; sodium:phosphate symporter activity [GO:0005436]; cochlea development [GO:0090102]; L-glutamate import [GO:0051938]; L-glutamate transmembrane transport [GO:0015813]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; neural retina development [GO:0003407]; neurotransmitter loading into synaptic vesicle [GO:0098700]; phosphate ion homeostasis [GO:0055062]; positive regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051951]; regulation of acetylcholine uptake [GO:0051631]; regulation of synapse structure or activity [GO:0050803]; sensory perception of sound [GO:0007605]; sodium-dependent phosphate transport [GO:0044341]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q7TSF2}. Cell membrane {ECO:0000305|PubMed:33440152}; Multi-pass membrane protein {ECO:0000305}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q7TSF2}.
Q8NDX5	reviewed	PHC3_HUMAN	Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3)	PHC3 EDR3 PH3	Homo sapiens (Human)	983	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}.	MISCELLANEOUS: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.	negative regulation of DNA-templated transcription [GO:0045892]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; zinc ion binding [GO:0008270]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:21282530}.
Q8NDZ2	reviewed	SIMC1_HUMAN	SUMO-interacting motif-containing protein 1 (Platform element for inhibition of autolytic degradation)	SIMC1 C5orf25 PLEIAD	Homo sapiens (Human)	872	FUNCTION: Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SLF2 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication. {ECO:0000269|PubMed:36373674}.; FUNCTION: [Isoform 1]: Inhibits the protease activity of CAPN3. {ECO:0000269|PubMed:23707407}.; FUNCTION: [Isoform 5]: Inhibits the protease activity of CAPN3. {ECO:0000269|PubMed:23707407}.			cytoplasm [GO:0005737]; PML body [GO:0016605]; sarcomere [GO:0030017]	peptidase inhibitor activity [GO:0030414]; SUMO polymer binding [GO:0032184]	cytoplasm [GO:0005737]; PML body [GO:0016605]; sarcomere [GO:0030017]; peptidase inhibitor activity [GO:0030414]; SUMO polymer binding [GO:0032184]	SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000269|PubMed:36373674}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:23707407}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:23707407}.
Q8NDZ4	reviewed	DIK2A_HUMAN	Divergent protein kinase domain 2A (Deleted in autism protein 1) (Golgi Protein of 49 kDa) (GoPro49) (Hypoxia and AKT-induced stem cell factor) (HASF)	DIPK2A C3orf58 DIA1	Homo sapiens (Human)	430	FUNCTION: May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade. {ECO:0000269|PubMed:23784961}.		cardiac muscle cell proliferation [GO:0060038]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; positive regulation of protein kinase C activity [GO:1900020]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]	COPI vesicle coat [GO:0030126]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]		COPI vesicle coat [GO:0030126]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; cardiac muscle cell proliferation [GO:0060038]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; positive regulation of protein kinase C activity [GO:1900020]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPI-coated vesicle. Golgi apparatus. Secreted.
Q8NE01	reviewed	CNNM3_HUMAN	Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3)	CNNM3 ACDP3	Homo sapiens (Human)	707	FUNCTION: Probable metal transporter. {ECO:0000250}.	MISCELLANEOUS: Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.	magnesium ion homeostasis [GO:0010960]; monoatomic ion transport [GO:0006811]	membrane [GO:0016020]; plasma membrane [GO:0005886]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; magnesium ion homeostasis [GO:0010960]; monoatomic ion transport [GO:0006811]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q8NE09	reviewed	RGS22_HUMAN	Regulator of G-protein signaling 22 (RGS22)	RGS22	Homo sapiens (Human)	1264	FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to competing donor splice site. {ECO:0000305}.	negative regulation of signal transduction [GO:0009968]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634]	G-protein alpha-subunit binding [GO:0001965]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634]; G-protein alpha-subunit binding [GO:0001965]; negative regulation of signal transduction [GO:0009968]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18703424}. Nucleus {ECO:0000269|PubMed:18703424}. Note=Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus.
Q8NE31	reviewed	FA13C_HUMAN	Protein FAM13C	FAM13C FAM13C1	Homo sapiens (Human)	585							
Q8NE35	reviewed	CPEB3_HUMAN	Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (hCPEB-3)	CPEB3 KIAA0940	Homo sapiens (Human)	698	FUNCTION: Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195). {ECO:0000250|UniProtKB:Q7TN99, ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:26398195}.	MISCELLANEOUS: The CPEB3 gene contains an intron-encoded self-cleaving ribozyme which is structurally and biochemically related to human hepatitis delta virus ribozymes and which may play a role in the regulation of CPEB3 translation (PubMed:16990549). A polymorphism in the ribozyme sequence which influences cleavage activity of the ribozyme may play a role in episodic memory with carriers of a rare C allele-containing ribozyme showing significantly poorer memory recall performance than T allele carriers (PubMed:19503753). {ECO:0000269|PubMed:16990549, ECO:0000269|PubMed:19503753}.	3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to amino acid stimulus [GO:0071230]; long-term memory [GO:0007616]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of cytoplasmic translational elongation [GO:1900248]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of translation [GO:0045727]; regulation of dendritic spine development [GO:0060998]; regulation of synaptic plasticity [GO:0048167]	apical dendrite [GO:0097440]; CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; messenger ribonucleoprotein complex [GO:1990124]; midbody [GO:0030496]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; translation factor activity, RNA binding [GO:0008135]	apical dendrite [GO:0097440]; CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; messenger ribonucleoprotein complex [GO:1990124]; midbody [GO:0030496]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; translation factor activity, RNA binding [GO:0008135]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to amino acid stimulus [GO:0071230]; long-term memory [GO:0007616]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of cytoplasmic translational elongation [GO:1900248]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of translation [GO:0045727]; regulation of dendritic spine development [GO:0060998]; regulation of synaptic plasticity [GO:0048167]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:22730302}. Nucleus {ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:22730302}. Synapse {ECO:0000250|UniProtKB:Q7TN99}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TN99}. Postsynaptic density {ECO:0000250|UniProtKB:Q7TN99}. Note=Predominantly cytoplasmic in unstimulated neurons but translocates to the nucleus following neuronal stimulation (PubMed:20639532, PubMed:22730302). Nuclear import is mediated by importin IPO5 (By similarity). {ECO:0000250|UniProtKB:Q7TN99, ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:22730302}.
Q8NE63	reviewed	HIPK4_HUMAN	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1)	HIPK4	Homo sapiens (Human)	616	FUNCTION: Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). {ECO:0000250, ECO:0000305}.		phosphorylation [GO:0016310]; regulation of signal transduction by p53 class mediator [GO:1901796]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; histone kinase activity [GO:0035173]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; histone kinase activity [GO:0035173]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; phosphorylation [GO:0016310]; regulation of signal transduction by p53 class mediator [GO:1901796]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8NE71	reviewed	ABCF1_HUMAN	ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein)	ABCF1 ABC50	Homo sapiens (Human)	845	FUNCTION: Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269|PubMed:19570978}.		inflammatory response [GO:0006954]; positive regulation of translation [GO:0045727]; translation [GO:0006412]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]; translation factor activity, RNA binding [GO:0008135]; inflammatory response [GO:0006954]; positive regulation of translation [GO:0045727]; translation [GO:0006412]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19570978}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19570978}. Nucleus envelope {ECO:0000269|PubMed:19570978}.
Q8NE79	reviewed	POPD1_HUMAN	Blood vessel epicardial substance (hBVES) (Popeye domain-containing protein 1) (Popeye protein 1)	BVES POP1 POPDC1	Homo sapiens (Human)	360	FUNCTION: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury. {ECO:0000250|UniProtKB:Q5PQZ7, ECO:0000250|UniProtKB:Q9ES83, ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:26642364}.		cell migration involved in heart development [GO:0060973]; epithelial cell-cell adhesion [GO:0090136]; heart development [GO:0007507]; hematopoietic progenitor cell differentiation [GO:0002244]; muscle organ development [GO:0007517]; positive regulation of locomotion [GO:0040017]; positive regulation of receptor recycling [GO:0001921]; regulation of cell shape [GO:0008360]; regulation of endocytic recycling [GO:2001135]; regulation of GTPase activity [GO:0043087]; regulation of heart rate [GO:0002027]; regulation of membrane potential [GO:0042391]; response to ischemia [GO:0002931]; sinoatrial node cell development [GO:0060931]; skeletal muscle tissue development [GO:0007519]; striated muscle cell differentiation [GO:0051146]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle docking [GO:0048278]; vesicle-mediated transport [GO:0016192]	bicellular tight junction [GO:0005923]; caveola [GO:0005901]; cell junction [GO:0030054]; cell projection membrane [GO:0031253]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	cAMP binding [GO:0030552]; structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; caveola [GO:0005901]; cell junction [GO:0030054]; cell projection membrane [GO:0031253]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; cAMP binding [GO:0030552]; structural molecule activity [GO:0005198]; cell migration involved in heart development [GO:0060973]; epithelial cell-cell adhesion [GO:0090136]; heart development [GO:0007507]; hematopoietic progenitor cell differentiation [GO:0002244]; muscle organ development [GO:0007517]; positive regulation of locomotion [GO:0040017]; positive regulation of receptor recycling [GO:0001921]; regulation of cell shape [GO:0008360]; regulation of endocytic recycling [GO:2001135]; regulation of GTPase activity [GO:0043087]; regulation of heart rate [GO:0002027]; regulation of membrane potential [GO:0042391]; response to ischemia [GO:0002931]; sinoatrial node cell development [GO:0060931]; skeletal muscle tissue development [GO:0007519]; striated muscle cell differentiation [GO:0051146]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle docking [GO:0048278]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Lateral cell membrane {ECO:0000269|PubMed:16188940}. Cell junction, tight junction {ECO:0000269|PubMed:16188940}. Membrane {ECO:0000269|PubMed:26642364}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000269|PubMed:26642364}. Membrane, caveola {ECO:0000250|UniProtKB:Q9ES83}. Note=Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells. {ECO:0000250|UniProtKB:Q9ES83}.
Q8NE86	reviewed	MCU_HUMAN	Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A)	MCU C10orf42 CCDC109A	Homo sapiens (Human)	351	FUNCTION: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276). participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity). {ECO:0000250|UniProtKB:Q3UMR5, ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:22822213, ECO:0000269|PubMed:22829870, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:23755363, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:25603276, ECO:0000269|PubMed:26341627, ECO:0000269|PubMed:26903221}.		calcium import into the mitochondrion [GO:0036444]; calcium-mediated signaling [GO:0019722]; glucose homeostasis [GO:0042593]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of insulin secretion [GO:0032024]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of neutrophil chemotaxis [GO:0090023]; protein complex oligomerization [GO:0051259]	calcium channel complex [GO:0034704]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246]	calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; uniporter activity [GO:0015292]	calcium channel complex [GO:0034704]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246]; calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; uniporter activity [GO:0015292]; calcium import into the mitochondrion [GO:0036444]; calcium-mediated signaling [GO:0019722]; glucose homeostasis [GO:0042593]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of insulin secretion [GO:0032024]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of neutrophil chemotaxis [GO:0090023]; protein complex oligomerization [GO:0051259]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:23755363, ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:27099988, ECO:0000305|PubMed:26341627}; Multi-pass membrane protein {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:24231807}.
Q8NEA6	reviewed	GLIS3_HUMAN	Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515)	GLIS3 ZNF515	Homo sapiens (Human)	775	FUNCTION: Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8NEA9	reviewed	GMCL2_HUMAN	Germ cell-less protein-like 2 (Germ cell-less protein-like 1-like)	GMCL2 GCL GMCL1L GMCL1P1	Homo sapiens (Human)	526	FUNCTION: Possible function in spermatogenesis. Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). {ECO:0000250|UniProtKB:Q920G9, ECO:0000269|PubMed:14528312}.	MISCELLANEOUS: According to some authors, GMCL2 is a GMCL retrogene on chromosome 5 which is likely to be functional. {ECO:0000305|PubMed:16201836}.	germ cell development [GO:0007281]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]	nuclear matrix [GO:0016363]; nucleus [GO:0005634]	cullin family protein binding [GO:0097602]	nuclear matrix [GO:0016363]; nucleus [GO:0005634]; cullin family protein binding [GO:0097602]; germ cell development [GO:0007281]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250|UniProtKB:Q920G9}.
Q8NEB5	reviewed	PLPP5_HUMAN	Phospholipid phosphatase 5 (EC 3.1.3.4) (EC 3.6.1.75) (Phosphatidic acid phosphatase type 2 domain-containing protein 1B)	PLPP5 DPPL1 HTPAP PPAPDC1B	Homo sapiens (Human)	264	FUNCTION: Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules (PubMed:17590538). {ECO:0000269|PubMed:17590538, ECO:0000303|PubMed:17590538}.	MISCELLANEOUS: May be a metastatic suppressor for hepatocellular carcinoma. {ECO:0000269|PubMed:16261160}.	phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	diacylglycerol diphosphate phosphatase activity [GO:0000810]; phosphatidate phosphatase activity [GO:0008195]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; diacylglycerol diphosphate phosphatase activity [GO:0000810]; phosphatidate phosphatase activity [GO:0008195]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:17590538}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q3UMZ3}.
Q8NEB9	reviewed	PK3C3_HUMAN	Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)	PIK3C3 VPS34	Homo sapiens (Human)	887	FUNCTION: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:7628435, PubMed:33637724). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}.		autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; autophagy of peroxisome [GO:0030242]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; macroautophagy [GO:0016236]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; positive regulation by host of viral genome replication [GO:0044829]; protein lipidation [GO:0006497]; protein localization to phagophore assembly site [GO:0034497]; protein targeting to lysosome [GO:0006622]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]; selective autophagy [GO:0061912]	autolysosome [GO:0044754]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; late endosome [GO:0005770]; membrane [GO:0016020]; midbody [GO:0030496]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]	autolysosome [GO:0044754]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; late endosome [GO:0005770]; membrane [GO:0016020]; midbody [GO:0030496]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; autophagy of peroxisome [GO:0030242]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; macroautophagy [GO:0016236]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; positive regulation by host of viral genome replication [GO:0044829]; protein lipidation [GO:0006497]; protein localization to phagophore assembly site [GO:0034497]; protein targeting to lysosome [GO:0006622]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]; selective autophagy [GO:0061912]	SUBCELLULAR LOCATION: Midbody {ECO:0000269|PubMed:20208530}. Late endosome {ECO:0000269|PubMed:14617358}. Cytoplasmic vesicle, autophagosome {ECO:0000305|PubMed:14617358}. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q6PF93, ECO:0000305|PubMed:14617358}.
Q8NEC5	reviewed	CTSR1_HUMAN	Cation channel sperm-associated protein 1 (CatSper1) (hCatSper)	CATSPER1	Homo sapiens (Human)	780	FUNCTION: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.		calcium ion transport [GO:0006816]; cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of monoatomic ion transmembrane transport [GO:0034765]; spermatogenesis [GO:0007283]	CatSper complex [GO:0036128]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]	calcium activated cation channel activity [GO:0005227]; voltage-gated calcium channel activity [GO:0005245]	CatSper complex [GO:0036128]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]; calcium activated cation channel activity [GO:0005227]; voltage-gated calcium channel activity [GO:0005245]; calcium ion transport [GO:0006816]; cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of monoatomic ion transmembrane transport [GO:0034765]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:16625279}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91ZR5}. Note=Specifically located in the principal piece of the sperm tail. {ECO:0000269|PubMed:16625279}.
Q8NEE6	reviewed	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 (Dynein regulatory complex subunit 6) (F-box/LRR-repeat protein 13)	FBXL13 DRC6 FBL13	Homo sapiens (Human)	735	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Specifically targets CEP192 isoform 3 for ubiquitin-mediated proteolysis and thereby acts as a regulator of microtubule nucleation activity (PubMed:29348145). {ECO:0000250|UniProtKB:A8JHD7, ECO:0000269|PubMed:29348145}.		SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; motile cilium [GO:0031514]; SCF ubiquitin ligase complex [GO:0019005]		cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; motile cilium [GO:0031514]; SCF ubiquitin ligase complex [GO:0019005]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8JHD7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29348145}.
Q8NEH6	reviewed	MNS1_HUMAN	Meiosis-specific nuclear structural protein 1	MNS1	Homo sapiens (Human)	495	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (PubMed:30148830). {ECO:0000250|UniProtKB:Q61884, ECO:0000269|PubMed:30148830, ECO:0000269|PubMed:36191189}.		cilium organization [GO:0044782]; left/right axis specification [GO:0070986]; meiotic cell cycle [GO:0051321]; positive regulation of cilium assembly [GO:0045724]; sperm axoneme assembly [GO:0007288]	axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; intermediate filament [GO:0005882]; motile cilium [GO:0031514]; nuclear envelope [GO:0005635]; sperm flagellum [GO:0036126]	identical protein binding [GO:0042802]	axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; intermediate filament [GO:0005882]; motile cilium [GO:0031514]; nuclear envelope [GO:0005635]; sperm flagellum [GO:0036126]; identical protein binding [GO:0042802]; cilium organization [GO:0044782]; left/right axis specification [GO:0070986]; meiotic cell cycle [GO:0051321]; positive regulation of cilium assembly [GO:0045724]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61884}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:30148830, ECO:0000269|PubMed:36191189}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:30148830}. Note=Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. {ECO:0000250|UniProtKB:Q2KIQ2}.
Q8NEJ0	reviewed	DUS18_HUMAN	Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 20) (LMW-DSP20)	DUSP18 LMWDSP20	Homo sapiens (Human)	188	FUNCTION: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). {ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617}.		dephosphorylation [GO:0016311]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation [GO:0035335]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; dephosphorylation [GO:0016311]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation [GO:0035335]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12408986}. Nucleus {ECO:0000269|PubMed:12408986}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8VE01}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VE01}; Intermembrane side {ECO:0000250|UniProtKB:Q8VE01}. Note=Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment. {ECO:0000250|UniProtKB:Q8VE01}.
Q8NEJ9	reviewed	NGDN_HUMAN	Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein)	NGDN C14orf120	Homo sapiens (Human)	315	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (PubMed:34516797). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9DB96, ECO:0000269|PubMed:34516797}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site. {ECO:0000305}.	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of translation at postsynapse [GO:0140245]; ribosomal small subunit biogenesis [GO:0042274]	axon [GO:0030424]; chromosome, centromeric region [GO:0000775]; dendrite [GO:0030425]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perforant pathway to dendrate granule cell synapse [GO:0140240]; postsynapse [GO:0098794]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	axon [GO:0030424]; chromosome, centromeric region [GO:0000775]; dendrite [GO:0030425]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perforant pathway to dendrate granule cell synapse [GO:0140240]; postsynapse [GO:0098794]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of translation at postsynapse [GO:0140245]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9DB96}. Nucleus, nucleolus {ECO:0000269|PubMed:18547334, ECO:0000269|PubMed:34516797}. Chromosome, centromere {ECO:0000269|PubMed:18547334}. Cytoplasm {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, axon {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9DB96}. Note=Translocated from nucleolus to nuclear foci in response to UV damage (By similarity). Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites. {ECO:0000250|UniProtKB:Q9DB96}.
Q8NEK8	reviewed	TET5D_HUMAN	Terminal nucleotidyltransferase 5D (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46D)	TENT5D FAM46D	Homo sapiens (Human)	389	FUNCTION: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group. {ECO:0000269|PubMed:28931820, ECO:0000269|PubMed:32433990}.		mRNA stabilization [GO:0048255]		poly(A) RNA polymerase activity [GO:1990817]	poly(A) RNA polymerase activity [GO:1990817]; mRNA stabilization [GO:0048255]	
Q8NEL9	reviewed	DDHD1_HUMAN	Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase)	DDHD1 KIAA1705	Homo sapiens (Human)	900	FUNCTION: Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (PubMed:20359546, PubMed:22922100) (Probable). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (PubMed:20359546) (Probable). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}.		lipid metabolic process [GO:0006629]; positive regulation of mitochondrial fission [GO:0090141]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	metal ion binding [GO:0046872]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; metal ion binding [GO:0046872]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]; lipid metabolic process [GO:0006629]; positive regulation of mitochondrial fission [GO:0090141]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15623529}.
Q8NEM0	reviewed	MCPH1_HUMAN	Microcephalin	MCPH1	Homo sapiens (Human)	835	FUNCTION: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}.	MISCELLANEOUS: MCPH1 deficient cells exhibit a delay in post-mitotic chromosome decondensation.	bone development [GO:0060348]; cerebral cortex development [GO:0021987]; establishment of mitotic spindle orientation [GO:0000132]; mitotic cell cycle [GO:0000278]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuronal stem cell population maintenance [GO:0097150]; protein localization to centrosome [GO:0071539]; regulation of centrosome cycle [GO:0046605]; regulation of chromosome condensation [GO:0060623]; regulation of inflammatory response [GO:0050727]	cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; bone development [GO:0060348]; cerebral cortex development [GO:0021987]; establishment of mitotic spindle orientation [GO:0000132]; mitotic cell cycle [GO:0000278]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuronal stem cell population maintenance [GO:0097150]; protein localization to centrosome [GO:0071539]; regulation of centrosome cycle [GO:0046605]; regulation of chromosome condensation [GO:0060623]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16479174}.
Q8NEM7	reviewed	SP20H_HUMAN	Transcription factor SPT20 homolog (p38-interacting protein) (p38IP)	SUPT20H C13orf19 FAM48A FP757	Homo sapiens (Human)	779	FUNCTION: Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}.		autophagy [GO:0006914]; gastrulation [GO:0007369]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461]	transcription coregulator activity [GO:0003712]	nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461]; transcription coregulator activity [GO:0003712]; autophagy [GO:0006914]; gastrulation [GO:0007369]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19893488}.
Q8NEM8	reviewed	CBPC3_HUMAN	Cytosolic carboxypeptidase 3 (EC 3.4.17.-) (ATP/GTP-binding protein-like 3) (Protein deglutamylase CCP3)	AGBL3 CCP3	Homo sapiens (Human)	1001	FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. May catalyze the hydrolysis of aspartate from the carboxy-terminus of target proteins. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of target proteins. {ECO:0000250|UniProtKB:Q8CDP0}.; FUNCTION: [Isoform 2]: Metallocarboxypeptidase that mediates tubulin deglutamylation. {ECO:0000269|PubMed:25103237}.		protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]	cytosol [GO:0005829]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8CDP0}.
Q8NEN9	reviewed	PDZD8_HUMAN	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104)	PDZD8 PDZK8	Homo sapiens (Human)	1154	FUNCTION: Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). {ECO:0000269|PubMed:21549406, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29097544}.		cytoskeleton organization [GO:0007010]; lipid transport [GO:0006869]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; regulation of cell morphogenesis [GO:0022604]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]	lipid binding [GO:0008289]; metal ion binding [GO:0046872]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; cytoskeleton organization [GO:0007010]; lipid transport [GO:0006869]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; regulation of cell morphogenesis [GO:0022604]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29097544}; Single-pass membrane protein {ECO:0000255}. Note=Localizes at mitochondria-endoplasmic reticulum contact sites. {ECO:0000269|PubMed:29097544}.
Q8NEP3	reviewed	DAAF1_HUMAN	Dynein axonemal assembly factor 1 (Leucine-rich repeat-containing protein 50)	DNAAF1 LRRC50	Homo sapiens (Human)	725	FUNCTION: Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli. {ECO:0000269|PubMed:18385425, ECO:0000269|PubMed:19944400, ECO:0000269|PubMed:19944405}.		axonemal dynein complex assembly [GO:0070286]; axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; left/right pattern formation [GO:0060972]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; regulation of cilium beat frequency [GO:0003356]	axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]	dynein complex binding [GO:0070840]	axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]; dynein complex binding [GO:0070840]; axonemal dynein complex assembly [GO:0070286]; axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; left/right pattern formation [GO:0060972]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; regulation of cilium beat frequency [GO:0003356]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:18385425}. Cytoplasm {ECO:0000269|PubMed:18385425}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18385425}. Note=In HEK293T cells, it is diffusely cytoplasmic and concentrates at the mitotic spindle poles, while in MDCK cells, it localizes in the cilium. In vivo, this protein is probably restricted to the cilium.
Q8NEQ6	reviewed	SRARP_HUMAN	Steroid receptor-associated and regulated protein (Estrogen receptor-related factor) (ER-related factor) (Steroid receptor-regulated protein)	SRARP C1orf64 ERRF SSPR	Homo sapiens (Human)	169	FUNCTION: May regulate the transcriptional function of androgen and estrogen receptors. {ECO:0000269|PubMed:22341523, ECO:0000269|PubMed:28915724}.		positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	nuclear estrogen receptor binding [GO:0030331]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; nuclear estrogen receptor binding [GO:0030331]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]	
Q8NER1	reviewed	TRPV1_HUMAN	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)	TRPV1 VR1	Homo sapiens (Human)	839	FUNCTION: Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. {ECO:0000250|UniProtKB:O35433, ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11226139, ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:12077606}.	MISCELLANEOUS: Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.	behavioral response to pain [GO:0048266]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to acidic pH [GO:0071468]; cellular response to alkaloid [GO:0071312]; cellular response to ATP [GO:0071318]; cellular response to heat [GO:0034605]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to temperature stimulus [GO:0071502]; cellular response to tumor necrosis factor [GO:0071356]; chemosensory behavior [GO:0007635]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; detection of temperature stimulus involved in thermoception [GO:0050960]; diet induced thermogenesis [GO:0002024]; fever generation [GO:0001660]; glutamate secretion [GO:0014047]; lipid metabolic process [GO:0006629]; microglial cell activation [GO:0001774]; negative regulation of establishment of blood-brain barrier [GO:0090212]; negative regulation of heart rate [GO:0010459]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptide secretion [GO:0002790]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; protein homotetramerization [GO:0051289]; response to capsazepine [GO:1901594]; response to peptide hormone [GO:0043434]; sensory perception of mechanical stimulus [GO:0050954]; smooth muscle contraction involved in micturition [GO:0060083]; thermoception [GO:0050955]	dendritic spine membrane [GO:0032591]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calcium-release channel activity [GO:0015278]; calmodulin binding [GO:0005516]; chloride channel regulator activity [GO:0017081]; excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; phosphoprotein binding [GO:0051219]; temperature-gated ion channel activity [GO:0097603]; transmembrane signaling receptor activity [GO:0004888]; voltage-gated calcium channel activity [GO:0005245]	dendritic spine membrane [GO:0032591]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calcium-release channel activity [GO:0015278]; calmodulin binding [GO:0005516]; chloride channel regulator activity [GO:0017081]; excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; phosphoprotein binding [GO:0051219]; temperature-gated ion channel activity [GO:0097603]; transmembrane signaling receptor activity [GO:0004888]; voltage-gated calcium channel activity [GO:0005245]; behavioral response to pain [GO:0048266]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to acidic pH [GO:0071468]; cellular response to alkaloid [GO:0071312]; cellular response to ATP [GO:0071318]; cellular response to heat [GO:0034605]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to temperature stimulus [GO:0071502]; cellular response to tumor necrosis factor [GO:0071356]; chemosensory behavior [GO:0007635]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; detection of temperature stimulus involved in thermoception [GO:0050960]; diet induced thermogenesis [GO:0002024]; fever generation [GO:0001660]; glutamate secretion [GO:0014047]; lipid metabolic process [GO:0006629]; microglial cell activation [GO:0001774]; negative regulation of establishment of blood-brain barrier [GO:0090212]; negative regulation of heart rate [GO:0010459]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptide secretion [GO:0002790]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; protein homotetramerization [GO:0051289]; response to capsazepine [GO:1901594]; response to peptide hormone [GO:0043434]; sensory perception of mechanical stimulus [GO:0050954]; smooth muscle contraction involved in micturition [GO:0060083]; thermoception [GO:0050955]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:O35433}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O35433}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:O35433}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O35433}. Cell membrane {ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:12077606}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O35433}. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines. {ECO:0000250|UniProtKB:O35433}.
Q8NER5	reviewed	ACV1C_HUMAN	Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7)	ACVR1C ALK7	Homo sapiens (Human)	493	FUNCTION: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:15531507}.		activin receptor signaling pathway [GO:0032924]; apoptotic nuclear changes [GO:0030262]; cell differentiation [GO:0030154]; cellular response to growth factor stimulus [GO:0071363]; insulin secretion [GO:0030073]; lipid storage [GO:0019915]; negative regulation of chorionic trophoblast cell proliferation [GO:1901383]; negative regulation of insulin secretion [GO:0046676]; negative regulation of trophoblast cell migration [GO:1901164]; nervous system development [GO:0007399]; nodal signaling pathway [GO:0038092]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; protein phosphorylation [GO:0006468]; response to dietary excess [GO:0002021]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; trophectodermal cell proliferation [GO:0001834]	activin receptor complex [GO:0048179]; plasma membrane [GO:0005886]	activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; metal ion binding [GO:0046872]; nodal binding [GO:0038100]; protein serine/threonine kinase activity [GO:0004674]	activin receptor complex [GO:0048179]; plasma membrane [GO:0005886]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; metal ion binding [GO:0046872]; nodal binding [GO:0038100]; protein serine/threonine kinase activity [GO:0004674]; activin receptor signaling pathway [GO:0032924]; apoptotic nuclear changes [GO:0030262]; cell differentiation [GO:0030154]; cellular response to growth factor stimulus [GO:0071363]; insulin secretion [GO:0030073]; lipid storage [GO:0019915]; negative regulation of chorionic trophoblast cell proliferation [GO:1901383]; negative regulation of insulin secretion [GO:0046676]; negative regulation of trophoblast cell migration [GO:1901164]; nervous system development [GO:0007399]; nodal signaling pathway [GO:0038092]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; protein phosphorylation [GO:0006468]; response to dietary excess [GO:0002021]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; trophectodermal cell proliferation [GO:0001834]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12606401}; Single-pass type I membrane protein {ECO:0000269|PubMed:12606401}.
Q8NES3	reviewed	LFNG_HUMAN	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)	LFNG	Homo sapiens (Human)	379	FUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity). {ECO:0000250|UniProtKB:O09010, ECO:0000269|PubMed:11346656}.		animal organ morphogenesis [GO:0009887]; compartment pattern specification [GO:0007386]; marginal zone B cell differentiation [GO:0002315]; negative regulation of Notch signaling pathway involved in somitogenesis [GO:1902367]; ovarian follicle development [GO:0001541]; positive regulation of meiotic cell cycle [GO:0051446]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of Notch signaling pathway [GO:0008593]; regulation of somitogenesis [GO:0014807]; somitogenesis [GO:0001756]; T cell differentiation [GO:0030217]	extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; Golgi membrane [GO:0000139]	metal ion binding [GO:0046872]; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity [GO:0033829]	extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; Golgi membrane [GO:0000139]; metal ion binding [GO:0046872]; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity [GO:0033829]; animal organ morphogenesis [GO:0009887]; compartment pattern specification [GO:0007386]; marginal zone B cell differentiation [GO:0002315]; negative regulation of Notch signaling pathway involved in somitogenesis [GO:1902367]; ovarian follicle development [GO:0001541]; positive regulation of meiotic cell cycle [GO:0051446]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of Notch signaling pathway [GO:0008593]; regulation of somitogenesis [GO:0014807]; somitogenesis [GO:0001756]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q8NET5	reviewed	NFAM1_HUMAN	NFAT activation molecule 1 (Calcineurin/NFAT-activating ITAM-containing protein) (NFAT-activating protein with ITAM motif 1)	NFAM1 CNAIP	Homo sapiens (Human)	270	FUNCTION: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. {ECO:0000269|PubMed:12615919, ECO:0000269|PubMed:15143214}.		B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; regulation of B cell differentiation [GO:0045577]; signal transduction [GO:0007165]	azurophil granule membrane [GO:0035577]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	azurophil granule membrane [GO:0035577]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; regulation of B cell differentiation [GO:0045577]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Partially recruited to lipid rafts upon BCR stimulation. {ECO:0000250}.
Q8NET6	reviewed	CHSTD_HUMAN	Carbohydrate sulfotransferase 13 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 3) (Chondroitin 4-sulfotransferase 3) (C4ST-3) (C4ST3)	CHST13	Homo sapiens (Human)	341	FUNCTION: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.		carbohydrate biosynthetic process [GO:0016051]; chondroitin sulfate biosynthetic process [GO:0030206]; proteoglycan biosynthetic process [GO:0030166]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	chondroitin 4-sulfotransferase activity [GO:0047756]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; chondroitin 4-sulfotransferase activity [GO:0047756]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; sulfotransferase activity [GO:0008146]; carbohydrate biosynthetic process [GO:0016051]; chondroitin sulfate biosynthetic process [GO:0030206]; proteoglycan biosynthetic process [GO:0030166]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q8NET8	reviewed	TRPV3_HUMAN	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3)	TRPV3	Homo sapiens (Human)	790	FUNCTION: Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771}.		calcium ion transmembrane transport [GO:0070588]; negative regulation of hair cycle [GO:0042636]; positive regulation of calcium ion import [GO:0090280]; response to temperature stimulus [GO:0009266]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]	calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; calcium ion transmembrane transport [GO:0070588]; negative regulation of hair cycle [GO:0042636]; positive regulation of calcium ion import [GO:0090280]; response to temperature stimulus [GO:0009266]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q8NEU8	reviewed	DP13B_HUMAN	DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)	APPL2 DIP13B	Homo sapiens (Human)	664	FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}.		adiponectin-activated signaling pathway [GO:0033211]; cell cycle [GO:0007049]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cold acclimation [GO:0009631]; diet induced thermogenesis [GO:0002024]; glucose homeostasis [GO:0042593]; negative regulation of cellular response to insulin stimulus [GO:1900077]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of glucose import [GO:0046325]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neurogenesis [GO:0050768]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451]; positive regulation of macropinocytosis [GO:1905303]; positive regulation of phagocytosis, engulfment [GO:0060100]; protein homotetramerization [GO:0051289]; protein import into nucleus [GO:0006606]; regulation of fibroblast migration [GO:0010762]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of innate immune response [GO:0045088]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; signal transduction [GO:0007165]; signaling [GO:0023052]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; early phagosome membrane [GO:0036186]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; macropinosome [GO:0044354]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; vesicle [GO:0031982]	identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; early phagosome membrane [GO:0036186]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; macropinosome [GO:0044354]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; vesicle [GO:0031982]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; adiponectin-activated signaling pathway [GO:0033211]; cell cycle [GO:0007049]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cold acclimation [GO:0009631]; diet induced thermogenesis [GO:0002024]; glucose homeostasis [GO:0042593]; negative regulation of cellular response to insulin stimulus [GO:1900077]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of glucose import [GO:0046325]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neurogenesis [GO:0050768]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451]; positive regulation of macropinocytosis [GO:1905303]; positive regulation of phagocytosis, engulfment [GO:0060100]; protein homotetramerization [GO:0051289]; protein import into nucleus [GO:0006606]; regulation of fibroblast migration [GO:0010762]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of innate immune response [GO:0045088]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; signal transduction [GO:0007165]; signaling [GO:0023052]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:15016378}; Peripheral membrane protein {ECO:0000269|PubMed:15016378}. Nucleus {ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:18034774}. Cell membrane {ECO:0000269|PubMed:18034774}. Endosome membrane {ECO:0000269|PubMed:21645192}. Cytoplasm {ECO:0000250|UniProtKB:Q8K3G9}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q8K3G9}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8K3G9}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q8K3G9}. Cell membrane {ECO:0000250|UniProtKB:Q8K3G9}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q8K3G9}. Note=Early endosomal membrane-bound and nuclear (PubMed:15016378). Translocated into the nucleus upon release from endosomal membranes following internalization of EGF (PubMed:15016378). Associates dynamically with cytoplasmic membrane structures that undergo changes in shape, movement, fusion and fission events (PubMed:18034774). PI(4,5)P2 levels are important for membrane association of APPL2 (PubMed:18034774). Absent of endosome in macrophage. Colocalized with RAB31 at early-stage phagosome (By similarity). Localized on macropinosomes in LPS-activated macrophages. Associated with membrane domains in contact with pathogens and pathogen-derived ligands like LPS. First recruited to the ruffles, and accumulates on macropinosomes (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:18034774}.
Q8NEV1	reviewed	CSK23_HUMAN	Casein kinase II subunit alpha 3 (CK II alpha 3) (EC 2.7.11.1) (Casein kinase II alpha 1 polypeptide pseudogene)	CSNK2A3 CSNK2A1P	Homo sapiens (Human)	391	FUNCTION: Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression. {ECO:0000269|PubMed:20625391}.		positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein catabolic process [GO:0045732]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein kinase CK2 complex [GO:0005956]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein kinase CK2 complex [GO:0005956]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein catabolic process [GO:0045732]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]	
Q8NEV4	reviewed	MYO3A_HUMAN	Myosin-IIIa (EC 2.7.11.1)	MYO3A	Homo sapiens (Human)	1616	FUNCTION: Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity). {ECO:0000250|UniProtKB:Q8K3H5, ECO:0000269|PubMed:12032315}.		cochlea morphogenesis [GO:0090103]; positive regulation of filopodium assembly [GO:0051491]; protein autophosphorylation [GO:0046777]; regulation of actin filament length [GO:0030832]; response to stimulus [GO:0050896]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; filopodium [GO:0030175]; filopodium tip [GO:0032433]; myosin complex [GO:0016459]; photoreceptor inner segment [GO:0001917]; stereocilium tip [GO:0032426]	actin binding [GO:0003779]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; plus-end directed microfilament motor activity [GO:0060002]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; filopodium [GO:0030175]; filopodium tip [GO:0032433]; myosin complex [GO:0016459]; photoreceptor inner segment [GO:0001917]; stereocilium tip [GO:0032426]; actin binding [GO:0003779]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; plus-end directed microfilament motor activity [GO:0060002]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cochlea morphogenesis [GO:0090103]; positive regulation of filopodium assembly [GO:0051491]; protein autophosphorylation [GO:0046777]; regulation of actin filament length [GO:0030832]; response to stimulus [GO:0050896]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm {ECO:0000269|PubMed:25822849}. Cell projection, filopodium tip {ECO:0000269|PubMed:25822849}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q8K3H5}. Note=Increased localization at the filodium tip seen in the presence of MORN4. {ECO:0000269|PubMed:25822849}.
Q8NEV8	reviewed	EXPH5_HUMAN	Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b)	EXPH5 KIAA0624 SLAC2B	Homo sapiens (Human)	1989	FUNCTION: May act as Rab effector protein and play a role in vesicle trafficking.		intracellular protein transport [GO:0006886]; keratinocyte development [GO:0003334]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exocytosis [GO:0045921]; positive regulation of protein secretion [GO:0050714]	endosome [GO:0005768]	small GTPase binding [GO:0031267]	endosome [GO:0005768]; small GTPase binding [GO:0031267]; intracellular protein transport [GO:0006886]; keratinocyte development [GO:0003334]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exocytosis [GO:0045921]; positive regulation of protein secretion [GO:0050714]	
Q8NEV9	reviewed	IL27A_HUMAN	Interleukin-27 subunit alpha (IL-27 subunit alpha) (IL-27-A) (IL27-A) (Interleukin-30) (p28)	IL27 IL27A IL30	Homo sapiens (Human)	243	FUNCTION: Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of pro-inflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses pro-inflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication. {ECO:0000269|PubMed:12121660, ECO:0000269|PubMed:14565860, ECO:0000269|PubMed:17068156, ECO:0000269|PubMed:18191724}.		inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type II interferon production [GO:0032729]; regulation of T cell proliferation [GO:0042129]; regulation of T-helper 1 cell differentiation [GO:0045625]; response to Gram-positive bacterium [GO:0140459]	cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; interleukin-27 receptor binding [GO:0045523]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; interleukin-27 receptor binding [GO:0045523]; signaling receptor binding [GO:0005102]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type II interferon production [GO:0032729]; regulation of T cell proliferation [GO:0042129]; regulation of T-helper 1 cell differentiation [GO:0045625]; response to Gram-positive bacterium [GO:0140459]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12121660}. Note=Does not seem to be secreted without coexpression of EBI3.
Q8NEW0	reviewed	ZNT7_HUMAN	Zinc transporter 7 (ZnT-7) (Solute carrier family 30 member 7) (Znt-like transporter 2)	SLC30A7 ZNT7 ZNTL2	Homo sapiens (Human)	376	FUNCTION: Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed:15525635, PubMed:15994300). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (PubMed:15525635, PubMed:15994300). {ECO:0000269|PubMed:15525635, ECO:0000269|PubMed:15994300}.		intracellular zinc ion homeostasis [GO:0006882]; sequestering of zinc ion [GO:0032119]; zinc ion import into Golgi lumen [GO:1904257]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; Golgi cis cisterna membrane [GO:1990674]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum membrane [GO:0033017]; vesicle [GO:0031982]	zinc ion transmembrane transporter activity [GO:0005385]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; Golgi cis cisterna membrane [GO:1990674]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum membrane [GO:0033017]; vesicle [GO:0031982]; zinc ion transmembrane transporter activity [GO:0005385]; intracellular zinc ion homeostasis [GO:0006882]; sequestering of zinc ion [GO:0032119]; zinc ion import into Golgi lumen [GO:1904257]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15525635}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9JKN1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9JKN1}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q5BJM8}. Mitochondrion {ECO:0000250|UniProtKB:Q5BJM8}.
Q8NEY1	reviewed	NAV1_HUMAN	Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1)	NAV1 KIAA1151 KIAA1213 POMFIL3 STEERIN1	Homo sapiens (Human)	1877	FUNCTION: May be involved in neuronal migration. {ECO:0000250}.		microtubule bundle formation [GO:0001578]; neuron migration [GO:0001764]	axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]	ATP hydrolysis activity [GO:0016887]	axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; ATP hydrolysis activity [GO:0016887]; microtubule bundle formation [GO:0001578]; neuron migration [GO:0001764]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones (By similarity). {ECO:0000250}.
Q8NEY4	reviewed	VATC2_HUMAN	V-type proton ATPase subunit C 2 (V-ATPase subunit C 2) (Vacuolar proton pump subunit C 2)	ATP6V1C2	Homo sapiens (Human)	427	FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). {ECO:0000250|UniProtKB:P21282, ECO:0000250|UniProtKB:P21283, ECO:0000250|UniProtKB:P31412}.		positive regulation of Wnt signaling pathway [GO:0030177]; regulation of macroautophagy [GO:0016241]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	identical protein binding [GO:0042802]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]; identical protein binding [GO:0042802]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of macroautophagy [GO:0016241]	
Q8NEY8	reviewed	PPHLN_HUMAN	Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50)	PPHLN1 HSPC206 HSPC232	Homo sapiens (Human)	458	FUNCTION: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}.	MISCELLANEOUS: [Isoform 5]: May be due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: May be due to intron retention. {ECO:0000305}.	keratinization [GO:0031424]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; protein localization to heterochromatin [GO:0097355]	chromosome [GO:0005694]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	chromosome [GO:0005694]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; keratinization [GO:0031424]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; protein localization to heterochromatin [GO:0097355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12853457, ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:26022416}. Cytoplasm {ECO:0000269|PubMed:12853457}. Chromosome {ECO:0000269|PubMed:26022416}. Note=In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions (PubMed:12853457). Localizes to chromatin (PubMed:26022416). {ECO:0000269|PubMed:12853457, ECO:0000269|PubMed:26022416}.
Q8NEZ2	reviewed	VP37A_HUMAN	Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1)	VPS37A HCRP1	Homo sapiens (Human)	397	FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15240819}.		macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]	centrosome [GO:0005813]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; nucleoplasm [GO:0005654]		centrosome [GO:0005813]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; nucleoplasm [GO:0005654]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Late endosome membrane; Peripheral membrane protein. Nucleus.
Q8NEZ3	reviewed	WDR19_HUMAN	WD repeat-containing protein 19 (Intraflagellar transport 144 homolog)	WDR19 IFT144 KIAA1638	Homo sapiens (Human)	1342	FUNCTION: As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly (PubMed:20889716). Essential for functional IFT-A assembly and ciliary entry of GPCRs (PubMed:20889716). Associates with the BBSome complex to mediate ciliary transport (By similarity). {ECO:0000250|UniProtKB:Q3UGF1, ECO:0000269|PubMed:20889716}.		cell morphogenesis [GO:0000902]; ciliary receptor clustering involved in smoothened signaling pathway [GO:0060830]; cilium assembly [GO:0060271]; digestive system development [GO:0055123]; ear morphogenesis [GO:0042471]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; gonad development [GO:0008406]; in utero embryonic development [GO:0001701]; intraciliary retrograde transport [GO:0035721]; myotome development [GO:0061055]; nervous system process [GO:0050877]; protein localization to ciliary membrane [GO:1903441]; protein-containing complex assembly [GO:0065003]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]	ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intraciliary transport particle A [GO:0030991]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]		ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intraciliary transport particle A [GO:0030991]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; cell morphogenesis [GO:0000902]; ciliary receptor clustering involved in smoothened signaling pathway [GO:0060830]; cilium assembly [GO:0060271]; digestive system development [GO:0055123]; ear morphogenesis [GO:0042471]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; gonad development [GO:0008406]; in utero embryonic development [GO:0001701]; intraciliary retrograde transport [GO:0035721]; myotome development [GO:0061055]; nervous system process [GO:0050877]; protein localization to ciliary membrane [GO:1903441]; protein-containing complex assembly [GO:0065003]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q3UGF1}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q3UGF1}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q3UGF1}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:32323121}. Note=Localizes to photoreceptor connecting cilia, to the base of motile cilia in brain ependymal cells and to the base of and along primary cilia in kidney cells. Localizes at the sperm neck and flagellum (PubMed:32323121). {ECO:0000250|UniProtKB:Q3UGF1, ECO:0000269|PubMed:32323121}.
Q8NEZ4	reviewed	KMT2C_HUMAN	Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)	KMT2C HALR KIAA1506 MLL3	Homo sapiens (Human)	4911	FUNCTION: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:24081332, PubMed:22266653). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.	MISCELLANEOUS: Found in a critical region of chromosome 7, which is commonly deleted in malignant myeloid disorders. Partial duplication of the KMT2C gene are found in the juxtacentromeric region of chromosomes 1, 2, 13 and 21. Juxtacentromeric reshuffling of the KMT2C gene has generated the BAGE genes.	methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to electrical stimulus [GO:0051602]	cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	acyltransferase activity [GO:0016746]; DNA binding [GO:0003677]; histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; acyltransferase activity [GO:0016746]; DNA binding [GO:0003677]; histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to electrical stimulus [GO:0051602]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23508102}.
Q8NEZ5	reviewed	FBX22_HUMAN	F-box only protein 22 (F-box protein FBX22p44)	FBXO22 FBX22	Homo sapiens (Human)	403	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. {ECO:0000269|PubMed:22972877}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to starvation [GO:0009267]; nucleocytoplasmic transport [GO:0006913]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein modification process [GO:0036211]; regulation of skeletal muscle fiber development [GO:0048742]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; nucleus [GO:0005634]; Z disc [GO:0030018]	ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nucleus [GO:0005634]; Z disc [GO:0030018]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to starvation [GO:0009267]; nucleocytoplasmic transport [GO:0006913]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein modification process [GO:0036211]; regulation of skeletal muscle fiber development [GO:0048742]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
Q8NF37	reviewed	PCAT1_HUMAN	Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3)	LPCAT1 AYTL2 PFAAP3	Homo sapiens (Human)	534	FUNCTION: Exhibits acyltransferase activity (PubMed:21498505, PubMed:18156367). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505, PubMed:18156367). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198). {ECO:0000250|UniProtKB:Q3TFD2, ECO:0000269|PubMed:18156367, ECO:0000269|PubMed:21498505, ECO:0000269|PubMed:25491198}.		negative regulation of phosphatidylcholine biosynthetic process [GO:2001246]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid biosynthetic process [GO:0008654]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; retina development in camera-type eye [GO:0060041]; surfactant homeostasis [GO:0043129]	azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-alkenylglycerophosphocholine O-acyltransferase activity [GO:0047159]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 1-alkylglycerophosphocholine O-acyltransferase activity [GO:0047191]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; calcium ion binding [GO:0005509]; lysophosphatidic acid acyltransferase activity [GO:0042171]; plasmalogen synthase activity [GO:0050200]	azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-alkenylglycerophosphocholine O-acyltransferase activity [GO:0047159]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 1-alkylglycerophosphocholine O-acyltransferase activity [GO:0047191]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; calcium ion binding [GO:0005509]; lysophosphatidic acid acyltransferase activity [GO:0042171]; plasmalogen synthase activity [GO:0050200]; negative regulation of phosphatidylcholine biosynthetic process [GO:2001246]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid biosynthetic process [GO:0008654]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; retina development in camera-type eye [GO:0060041]; surfactant homeostasis [GO:0043129]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q3TFD2}; Single-pass type II membrane protein {ECO:0000305|PubMed:21498505}. Cell membrane {ECO:0000305|PubMed:18156367}; Single-pass type II membrane protein {ECO:0000305|PubMed:21498505}. Lipid droplet {ECO:0000269|PubMed:21498505}. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm. {ECO:0000269|PubMed:21498505}.
Q8NF50	reviewed	DOCK8_HUMAN	Dedicator of cytokinesis protein 8	DOCK8	Homo sapiens (Human)	2099	FUNCTION: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). {ECO:0000250|UniProtKB:Q8C147, ECO:0000269|PubMed:22461490, ECO:0000269|PubMed:25762780, ECO:0000269|PubMed:28028151}.		cellular response to chemokine [GO:1990869]; dendritic cell migration [GO:0036336]; immunological synapse formation [GO:0001771]; memory T cell proliferation [GO:0061485]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of GTPase activity [GO:0043547]; positive regulation of T cell migration [GO:2000406]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium membrane [GO:0031258]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium membrane [GO:0031258]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; cellular response to chemokine [GO:1990869]; dendritic cell migration [GO:0036336]; immunological synapse formation [GO:0001771]; memory T cell proliferation [GO:0061485]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of GTPase activity [GO:0043547]; positive regulation of T cell migration [GO:2000406]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28028151}. Cell membrane {ECO:0000269|PubMed:28028151}; Peripheral membrane protein {ECO:0000305|PubMed:28028151}; Cytoplasmic side {ECO:0000305}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:28028151}; Peripheral membrane protein {ECO:0000305|PubMed:28028151}; Cytoplasmic side {ECO:0000305}. Note=Enriched and co-localizes with GTPase CDC42 at the immunological synapse formed during T cell/antigen presenting cell cognate interaction. Translocates from the cytoplasm to the plasma membrane in response to chemokine CXCL12/SDF-1-alpha stimulation. {ECO:0000269|PubMed:28028151}.
Q8NF64	reviewed	ZMIZ2_HUMAN	Zinc finger MIZ domain-containing protein 2 (PIAS-like protein Zimp7)	ZMIZ2 KIAA1886 ZIMP7 HRIHFB2007	Homo sapiens (Human)	920	FUNCTION: Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors. {ECO:0000269|PubMed:16051670}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]; regulation of transcription by RNA polymerase II [GO:0006357]	mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear receptor coactivator activity [GO:0030374]; SUMO ligase activity [GO:0061665]; zinc ion binding [GO:0008270]	mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear receptor coactivator activity [GO:0030374]; SUMO ligase activity [GO:0061665]; zinc ion binding [GO:0008270]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16051670, ECO:0000269|PubMed:9853615}. Note=Detected at replication foci throughout S phase.
Q8NF91	reviewed	SYNE1_HUMAN	Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1)	SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1	Homo sapiens (Human)	8797	FUNCTION: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}.	MISCELLANEOUS: [Isoform 10]: Lost in uterus, cervix, kidney, lung, thyroid and pancreas carcinomas, already at early tumor stages. {ECO:0000269|PubMed:18709643}.; MISCELLANEOUS: [Isoform 11]: Muscle-specific. {ECO:0000305}.; MISCELLANEOUS: [Isoform GSRP-56]: Interacts with TRPV2. {ECO:0000269|PubMed:16875688}.	cardiac muscle cell differentiation [GO:0055007]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of mini excitatory postsynaptic potential [GO:0061886]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleus organization [GO:0006997]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of dendrite morphogenesis [GO:0048814]; regulation of nucleus organization [GO:1903353]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; response to light stimulus [GO:0009416]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendritic spine head [GO:0044327]; Golgi apparatus [GO:0005794]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic membrane [GO:0045211]; sarcomere [GO:0030017]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeleton-nuclear membrane anchor activity [GO:0140444]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendritic spine head [GO:0044327]; Golgi apparatus [GO:0005794]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic membrane [GO:0045211]; sarcomere [GO:0030017]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeleton-nuclear membrane anchor activity [GO:0140444]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; cardiac muscle cell differentiation [GO:0055007]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of mini excitatory postsynaptic potential [GO:0061886]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleus organization [GO:0006997]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of dendrite morphogenesis [GO:0048814]; regulation of nucleus organization [GO:1903353]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; response to light stimulus [GO:0009416]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Nucleus. Nucleus envelope. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere. Note=The largest part of the protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. In skeletal and smooth muscles, a significant amount is found in the sarcomeres. In myoblasts, relocalized from the nuclear envelope to the nucleus and cytoplasm during cell differentiation.; SUBCELLULAR LOCATION: [Isoform GSRP-56]: Golgi apparatus {ECO:0000269|PubMed:16875688}.
Q8NF99	reviewed	ZN397_HUMAN	Zinc finger protein 397 (Zinc finger and SCAN domain-containing protein 15) (Zinc finger protein 47)	ZNF397 ZNF47 ZSCAN15	Homo sapiens (Human)	534	FUNCTION: Isoform 3 acts as a DNA-dependent transcriptional repressor. {ECO:0000269|PubMed:12801647}.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm.
Q8NFA0	reviewed	UBP32_HUMAN	Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32)	USP32 USP10	Homo sapiens (Human)	1604	FUNCTION: Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874). {ECO:0000269|PubMed:36476874}.		positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	calcium ion binding [GO:0005509]; cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; calcium ion binding [GO:0005509]; cysteine-type deubiquitinase activity [GO:0004843]; positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:20549504}; Lipid-anchor {ECO:0000305}.
Q8NFA2	reviewed	NOXO1_HUMAN	NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5)	NOXO1 P41NOX SH3PXD5	Homo sapiens (Human)	376	FUNCTION: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:15949904, ECO:0000269|PubMed:16329988, ECO:0000269|PubMed:17126813, ECO:0000269|PubMed:19755710}.		extracellular matrix disassembly [GO:0022617]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of respiratory burst [GO:0060263]; superoxide anion generation [GO:0042554]	cytoplasm [GO:0005737]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]; phosphatidylinositol binding [GO:0035091]; phospholipid binding [GO:0005543]; superoxide-generating NADPH oxidase activator activity [GO:0016176]	cytoplasm [GO:0005737]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; phosphatidylinositol binding [GO:0035091]; phospholipid binding [GO:0005543]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; extracellular matrix disassembly [GO:0022617]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of respiratory burst [GO:0060263]; superoxide anion generation [GO:0042554]	SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:12716910}; Peripheral membrane protein {ECO:0000269|PubMed:12716910}; Cytoplasmic side {ECO:0000269|PubMed:12716910}. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910).
Q8NFB2	reviewed	T185A_HUMAN	Transmembrane protein 185A (Protein FAM11A)	TMEM185A CXorf13 FAM11A	Homo sapiens (Human)	350				dendrite [GO:0030425]; membrane [GO:0016020]		dendrite [GO:0030425]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NFC6	reviewed	BD1L1_HUMAN	Biorientation of chromosomes in cell division protein 1-like 1	BOD1L1 BOD1L FAM44A KIAA1327	Homo sapiens (Human)	3051	FUNCTION: Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; replication fork processing [GO:0031297]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; Set1C/COMPASS complex [GO:0048188]		chromosome [GO:0005694]; nucleoplasm [GO:0005654]; Set1C/COMPASS complex [GO:0048188]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; replication fork processing [GO:0031297]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|Ref.2}. Note=Localizes at replication forks: following DNA damage, localizes to damaged replication forks undergoing resection. {ECO:0000269|Ref.2}.
Q8NFD2	reviewed	ANKK1_HUMAN	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase)	ANKK1 PKK2 SGK288	Homo sapiens (Human)	765			phosphorylation [GO:0016310]; regulation of cell cycle process [GO:0010564]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]; regulation of cell cycle process [GO:0010564]	
Q8NFD5	reviewed	ARI1B_HUMAN	AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B) (BRG1-associated factor 250b) (BAF250B) (BRG1-binding protein hELD/OSA1) (Osa homolog 2) (hOsa2) (p250R)	ARID1B BAF250B DAN15 KIAA1235 OSA2	Homo sapiens (Human)	2319	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250|UniProtKB:E9Q4N7, ECO:0000269|PubMed:14982958, ECO:0000269|PubMed:15170388, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative initiation at Met-84 of isoform 5. {ECO:0000305}.	cellular response to angiotensin [GO:1904385]; chromatin remodeling [GO:0006338]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ischemia [GO:0002931]; transcription initiation-coupled chromatin remodeling [GO:0045815]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; cytosol [GO:0005829]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; SWI/SNF complex [GO:0016514]	DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; cytosol [GO:0005829]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; SWI/SNF complex [GO:0016514]; DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]; cellular response to angiotensin [GO:1904385]; chromatin remodeling [GO:0006338]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ischemia [GO:0002931]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:11988099}.
Q8NFF2	reviewed	NCKX4_HUMAN	Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4)	SLC24A4 NCKX4	Homo sapiens (Human)	622	FUNCTION: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:12379639, PubMed:26631410). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived (By similarity). May play a role in calcium transport during amelogenesis (PubMed:23375655, PubMed:24621671). {ECO:0000250|UniProtKB:Q8CGQ8, ECO:0000269|PubMed:12379639, ECO:0000269|PubMed:23375655, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:26631410}.		amelogenesis [GO:0097186]; calcium ion export across plasma membrane [GO:1990034]; calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to high light intensity [GO:0071486]; cone photoresponse recovery [GO:0036368]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; drinking behavior [GO:0042756]; enamel mineralization [GO:0070166]; intracellular calcium ion homeostasis [GO:0006874]; membrane repolarization [GO:0086009]; monoatomic ion transport [GO:0006811]; negative regulation of calcium-mediated signaling [GO:0050849]; olfactory nerve maturation [GO:0021630]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; potassium ion transmembrane transport [GO:0071805]; regulation of eating behavior [GO:1903998]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of signaling receptor activity [GO:0010469]; response to high light intensity [GO:0009644]; response to melanocyte-stimulating hormone [GO:1990680]; response to odorant [GO:1990834]; sensory perception of smell [GO:0007608]; sodium ion transmembrane transport [GO:0035725]	apical plasma membrane [GO:0016324]; cone photoreceptor outer segment [GO:0120199]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; symporter activity [GO:0015293]	apical plasma membrane [GO:0016324]; cone photoreceptor outer segment [GO:0120199]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; symporter activity [GO:0015293]; amelogenesis [GO:0097186]; calcium ion export across plasma membrane [GO:1990034]; calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to high light intensity [GO:0071486]; cone photoresponse recovery [GO:0036368]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; drinking behavior [GO:0042756]; enamel mineralization [GO:0070166]; intracellular calcium ion homeostasis [GO:0006874]; membrane repolarization [GO:0086009]; monoatomic ion transport [GO:0006811]; negative regulation of calcium-mediated signaling [GO:0050849]; olfactory nerve maturation [GO:0021630]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; potassium ion transmembrane transport [GO:0071805]; regulation of eating behavior [GO:1903998]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of signaling receptor activity [GO:0010469]; response to high light intensity [GO:0009644]; response to melanocyte-stimulating hormone [GO:1990680]; response to odorant [GO:1990834]; sensory perception of smell [GO:0007608]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26631410}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8CGQ8}.
Q8NFF5	reviewed	FAD1_HUMAN	FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region]	FLAD1 PP591	Homo sapiens (Human)	587	FUNCTION: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. {ECO:0000269|PubMed:16643857, ECO:0000269|PubMed:27259049}.		FAD biosynthetic process [GO:0006747]; riboflavin metabolic process [GO:0006771]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; FMN adenylyltransferase activity [GO:0003919]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; FMN adenylyltransferase activity [GO:0003919]; identical protein binding [GO:0042802]; FAD biosynthetic process [GO:0006747]; riboflavin metabolic process [GO:0006771]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion matrix {ECO:0000269|PubMed:20060505}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Q8NFG4	reviewed	FLCN_HUMAN	Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein)	FLCN BHD	Homo sapiens (Human)	579	FUNCTION: Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:31704029, PubMed:31672913, PubMed:34381247, PubMed:32612235, PubMed:36103527, PubMed:37079666). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:24448649, PubMed:31704029, PubMed:31672913, PubMed:32612235, PubMed:36103527, PubMed:37079666). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (PubMed:24095279, PubMed:31704029, PubMed:31672913, PubMed:32612235, PubMed:37079666). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (PubMed:31672913, PubMed:32612235). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:21209915, PubMed:24081491, PubMed:31672913, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (PubMed:30733432). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (PubMed:27072130). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (PubMed:27113757). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (PubMed:34381247). {ECO:0000250|UniProtKB:Q8QZS3, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27072130, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31272105, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34381247, ECO:0000269|PubMed:36103527, ECO:0000269|PubMed:37079666}.		cell proliferation involved in kidney development [GO:0072111]; cell-cell junction assembly [GO:0007043]; cellular response to amino acid starvation [GO:0034198]; cellular response to starvation [GO:0009267]; energy homeostasis [GO:0097009]; epithelial cell proliferation [GO:0050673]; ERK1 and ERK2 cascade [GO:0070371]; hemopoiesis [GO:0030097]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway [GO:0097193]; lysosome localization [GO:0032418]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation involved in kidney development [GO:1901723]; negative regulation of cellular respiration [GO:1901856]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of gene expression [GO:0010629]; negative regulation of glycolytic process [GO:0045820]; negative regulation of lysosome organization [GO:1905672]; negative regulation of mitochondrial DNA metabolic process [GO:1901859]; negative regulation of mitochondrion organization [GO:0010823]; negative regulation of muscle tissue development [GO:1901862]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of post-translational protein modification [GO:1901874]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of cell adhesion [GO:0045785]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of cytokinesis [GO:0032465]; regulation of histone acetylation [GO:0035065]; regulation of pro-B cell differentiation [GO:2000973]; regulation of protein phosphorylation [GO:0001932]; regulation of Ras protein signal transduction [GO:0046578]; regulation of TOR signaling [GO:0032006]; TOR signaling [GO:0031929]; transforming growth factor beta receptor signaling pathway [GO:0007179]	centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877]	centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877]; cell proliferation involved in kidney development [GO:0072111]; cell-cell junction assembly [GO:0007043]; cellular response to amino acid starvation [GO:0034198]; cellular response to starvation [GO:0009267]; energy homeostasis [GO:0097009]; epithelial cell proliferation [GO:0050673]; ERK1 and ERK2 cascade [GO:0070371]; hemopoiesis [GO:0030097]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway [GO:0097193]; lysosome localization [GO:0032418]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation involved in kidney development [GO:1901723]; negative regulation of cellular respiration [GO:1901856]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of gene expression [GO:0010629]; negative regulation of glycolytic process [GO:0045820]; negative regulation of lysosome organization [GO:1905672]; negative regulation of mitochondrial DNA metabolic process [GO:1901859]; negative regulation of mitochondrion organization [GO:0010823]; negative regulation of muscle tissue development [GO:1901862]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of post-translational protein modification [GO:1901874]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of cell adhesion [GO:0045785]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of cytokinesis [GO:0032465]; regulation of histone acetylation [GO:0035065]; regulation of pro-B cell differentiation [GO:2000973]; regulation of protein phosphorylation [GO:0001932]; regulation of Ras protein signal transduction [GO:0046578]; regulation of TOR signaling [GO:0032006]; TOR signaling [GO:0031929]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:29848618, ECO:0000269|PubMed:31672913}. Cytoplasm, cytosol {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:29848618, ECO:0000269|PubMed:31672913}. Cell projection, cilium {ECO:0000269|PubMed:23784378, ECO:0000269|PubMed:27072130}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23784378}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23784378}. Nucleus {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353}. Note=Localizes to lysosome membrane in amino acid-depleted conditions and relocalizes to the cytosol upon refeeding (PubMed:24095279, PubMed:29848618, PubMed:31672913). Colocalizes with FNIP1 and FNIP2 in the cytoplasm (PubMed:17028174, PubMed:18663353). Also localizes to motile and non-motile cilia, centrosomes and the mitotic spindle (PubMed:23784378). {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:23784378, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:29848618, ECO:0000269|PubMed:31672913}.
Q8NFH3	reviewed	NUP43_HUMAN	Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42)	NUP43	Homo sapiens (Human)	380	FUNCTION: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. {ECO:0000269|PubMed:17363900}.		cell division [GO:0051301]; chromosome segregation [GO:0007059]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]	cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
Q8NFH4	reviewed	NUP37_HUMAN	Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37)	NUP37	Homo sapiens (Human)	326	FUNCTION: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. {ECO:0000269|PubMed:17363900, ECO:0000269|PubMed:30179222}.		cell division [GO:0051301]; chromosome segregation [GO:0007059]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]	cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
Q8NFH5	reviewed	NUP35_HUMAN	Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53)	NUP35 MP44 NUP53	Homo sapiens (Human)	326	FUNCTION: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}.		cellular response to leukemia inhibitory factor [GO:1990830]; mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; phospholipid binding [GO:0005543]; structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; phospholipid binding [GO:0005543]; structural constituent of nuclear pore [GO:0017056]; cellular response to leukemia inhibitory factor [GO:1990830]; mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:12196509}. Nucleus membrane {ECO:0000269|PubMed:15703211}; Peripheral membrane protein {ECO:0000269|PubMed:15703211}. Note=Tightly associated with the nuclear membrane and lamina. {ECO:0000269|PubMed:15703211}.
Q8NFH8	reviewed	REPS2_HUMAN	RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2)	REPS2 POB1	Homo sapiens (Human)	660	FUNCTION: Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:9422736, PubMed:12771942, PubMed:10393179). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}.		endocytosis [GO:0006897]; endosomal transport [GO:0016197]; epidermal growth factor receptor signaling pathway [GO:0007173]; protein-containing complex assembly [GO:0065003]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; epidermal growth factor receptor signaling pathway [GO:0007173]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12771942}.
Q8NFJ5	reviewed	RAI3_HUMAN	Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)	GPRC5A GPCR5A RAI3 RAIG1	Homo sapiens (Human)	357	FUNCTION: Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). {ECO:0000250|UniProtKB:Q8BHL4, ECO:0000269|PubMed:18000218}.		negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; signal transduction [GO:0007165]	cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; vesicle [GO:0031982]	cadherin binding [GO:0045296]; G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295]	cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9857033}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9857033}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in perinuclear vesicles, probably Golgi-associated vesicles. {ECO:0000269|PubMed:18000218}.
Q8NFJ6	reviewed	PKR2_HUMAN	Prokineticin receptor 2 (PK-R2) (G-protein coupled receptor 73-like 1) (G-protein coupled receptor I5E) (GPR73b) (GPRg2)	PROKR2 GPR73L1 PKR2	Homo sapiens (Human)	384	FUNCTION: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.		circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	neuropeptide Y receptor activity [GO:0004983]	plasma membrane [GO:0005886]; neuropeptide Y receptor activity [GO:0004983]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18826963}; Multi-pass membrane protein.
Q8NFJ9	reviewed	BBS1_HUMAN	Bardet-Biedl syndrome 1 protein (BBS2-like protein 2)	BBS1 BBS2L2	Homo sapiens (Human)	593	FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986). Plays a role in olfactory cilium biogenesis/maintenance and trafficking (By similarity). {ECO:0000250|UniProtKB:Q3V3N7, ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.	MISCELLANEOUS: [Isoform 3]: Based on a readthrough transcript which may produce a DPP3-BBS1 fusion protein. {ECO:0000305}.	adult behavior [GO:0030534]; brain morphogenesis [GO:0048854]; cartilage development [GO:0051216]; cellular lipid metabolic process [GO:0044255]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; dendrite development [GO:0016358]; fat cell differentiation [GO:0045444]; fertilization [GO:0009566]; Golgi to plasma membrane protein transport [GO:0043001]; hippocampus development [GO:0021766]; hormone metabolic process [GO:0042445]; microtubule cytoskeleton organization [GO:0000226]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; non-motile cilium assembly [GO:1905515]; olfactory behavior [GO:0042048]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell morphogenesis [GO:0008594]; protein localization to cilium [GO:0061512]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; sensory perception of smell [GO:0007608]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual perception [GO:0007601]	axoneme [GO:0005930]; BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; motile cilium [GO:0031514]	patched binding [GO:0005113]; phosphoprotein binding [GO:0051219]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; smoothened binding [GO:0005119]	axoneme [GO:0005930]; BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; motile cilium [GO:0031514]; patched binding [GO:0005113]; phosphoprotein binding [GO:0051219]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; smoothened binding [GO:0005119]; adult behavior [GO:0030534]; brain morphogenesis [GO:0048854]; cartilage development [GO:0051216]; cellular lipid metabolic process [GO:0044255]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; dendrite development [GO:0016358]; fat cell differentiation [GO:0045444]; fertilization [GO:0009566]; Golgi to plasma membrane protein transport [GO:0043001]; hippocampus development [GO:0021766]; hormone metabolic process [GO:0042445]; microtubule cytoskeleton organization [GO:0000226]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; non-motile cilium assembly [GO:1905515]; olfactory behavior [GO:0042048]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell morphogenesis [GO:0008594]; protein localization to cilium [GO:0061512]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; sensory perception of smell [GO:0007608]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Q8NFL0	reviewed	B3GN7_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (BGnT-7) (Beta-1,3-Gn-T7) (Beta-1,3-N-acetylglucosaminyltransferase 7) (Beta3Gn-T7) (EC 2.4.1.-)	B3GNT7	Homo sapiens (Human)	401	FUNCTION: N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N- and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (PubMed:14706853, PubMed:17690104). Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency (PubMed:17690104) (By similarity). May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion (By similarity). {ECO:0000250|UniProtKB:Q8K0J2, ECO:0000269|PubMed:14706853, ECO:0000269|PubMed:17690104}.		keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	acetylglucosaminyltransferase activity [GO:0008375]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; UDP-glycosyltransferase activity [GO:0008194]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; acetylglucosaminyltransferase activity [GO:0008375]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; UDP-glycosyltransferase activity [GO:0008194]; keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8NFM4	reviewed	ADCY4_HUMAN	Adenylate cyclase type 4 (EC 4.6.1.1) (ATP pyrophosphate-lyase 4) (Adenylate cyclase type IV) (Adenylyl cyclase 4)	ADCY4	Homo sapiens (Human)	1077	FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. {ECO:0000250|UniProtKB:P26770}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21228062}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:11549699}.
Q8NFM7	reviewed	I17RD_HUMAN	Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (IL17Rhom) (Interleukin-17 receptor-like protein) (Sef homolog) (hSef)	IL17RD IL17RLM SEF UNQ6115/PRO20026	Homo sapiens (Human)	739	FUNCTION: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed:12958313, PubMed:12807873). Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK (PubMed:15239952). Mediates JNK activation and may be involved in apoptosis (By similarity). May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q8JZL1, ECO:0000269|PubMed:12807873, ECO:0000269|PubMed:12958313, ECO:0000269|PubMed:15239952}.		negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	interleukin-17 receptor activity [GO:0030368]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; interleukin-17 receptor activity [GO:0030368]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:14742870}; Single-pass type I membrane protein {ECO:0000269|PubMed:14742870}. Cell membrane {ECO:0000269|PubMed:14742870}; Single-pass type I membrane protein {ECO:0000269|PubMed:14742870}. Note=Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
Q8NFP4	reviewed	MDGA1_HUMAN	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3)	MDGA1 MAMDC3	Homo sapiens (Human)	955	FUNCTION: Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. {ECO:0000250, ECO:0000269|PubMed:23248271}.		brain development [GO:0007420]; cerebral cortex radially oriented cell migration [GO:0021799]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; regulation of presynapse assembly [GO:1905606]; regulation of synaptic membrane adhesion [GO:0099179]; spinal cord association neuron differentiation [GO:0021527]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; brain development [GO:0007420]; cerebral cortex radially oriented cell migration [GO:0021799]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; regulation of presynapse assembly [GO:1905606]; regulation of synaptic membrane adhesion [GO:0099179]; spinal cord association neuron differentiation [GO:0021527]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15922729}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:15922729}. Note=Associated with lipid rafts.
Q8NFP7	reviewed	NUD10_HUMAN	Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (DIPP-3-alpha) (DIPP3-alpha) (hDIPP3alpha) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha) (Diadenosine hexaphosphate hydrolase (AMP-forming)) (EC 3.6.1.60) (Nucleoside diphosphate-linked moiety X motif 10) (Nudix motif 10) (hAps2)	NUDT10 APS2 DIPP3A	Homo sapiens (Human)	164	FUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. {ECO:0000269|PubMed:12105228}.		adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; metal ion binding [GO:0046872]; adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:12121577}.
Q8NFP9	reviewed	NBEA_HUMAN	Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B)	NBEA BCL8B KIAA1544 LYST2	Homo sapiens (Human)	2946	FUNCTION: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}.		protein localization [GO:0008104]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	protein kinase binding [GO:0019901]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; protein kinase binding [GO:0019901]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q8NFQ8	reviewed	TOIP2_HUMAN	Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1)	TOR1AIP2 IFRG15 LULL1	Homo sapiens (Human)	470	FUNCTION: Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}.		endoplasmic reticulum organization [GO:0007029]; membrane organization [GO:0061024]; positive regulation of ATP-dependent activity [GO:0032781]; protein localization to nuclear envelope [GO:0090435]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]	ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; endoplasmic reticulum organization [GO:0007029]; membrane organization [GO:0061024]; positive regulation of ATP-dependent activity [GO:0032781]; protein localization to nuclear envelope [GO:0090435]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane.
Q8NFR3	reviewed	SPTSB_HUMAN	Serine palmitoyltransferase small subunit B (Protein ADMP) (Small subunit of serine palmitoyltransferase B) (ssSPTb)	SPTSSB ADMP C3orf57 SSSPTB	Homo sapiens (Human)	76	FUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:19416851). The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core (PubMed:19416851). Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851). {ECO:0000269|PubMed:19416851}.		ceramide biosynthetic process [GO:0046513]; endoplasmic reticulum organization [GO:0007029]; regulation of serine C-palmitoyltransferase activity [GO:1904220]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]	endoplasmic reticulum membrane [GO:0005789]; serine C-palmitoyltransferase complex [GO:0017059]	serine C-palmitoyltransferase activity [GO:0004758]	endoplasmic reticulum membrane [GO:0005789]; serine C-palmitoyltransferase complex [GO:0017059]; serine C-palmitoyltransferase activity [GO:0004758]; ceramide biosynthetic process [GO:0046513]; endoplasmic reticulum organization [GO:0007029]; regulation of serine C-palmitoyltransferase activity [GO:1904220]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NFR9	reviewed	I17RE_HUMAN	Interleukin-17 receptor E (IL-17 receptor E) (IL-17RE)	IL17RE UNQ3056/PRO9877	Homo sapiens (Human)	667	FUNCTION: Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. {ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:21993849}.		inflammatory response [GO:0006954]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	interleukin-17 receptor activity [GO:0030368]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; interleukin-17 receptor activity [GO:0030368]; inflammatory response [GO:0006954]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000305}.
Q8NFT2	reviewed	STEA2_HUMAN	Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1)	STEAP2 PCANAP1 STAMP1 UNQ6507/PRO23203	Homo sapiens (Human)	490	FUNCTION: Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). {ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8BWB6}.		copper ion import [GO:0015677]; copper ion import across plasma membrane [GO:0098705]; endocytosis [GO:0006897]; Golgi to plasma membrane transport [GO:0006893]; iron ion import across plasma membrane [GO:0098711]; regulated exocytosis [GO:0045055]; response to hormone [GO:0009725]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network transport vesicle [GO:0030140]	cupric reductase activity [GO:0008823]; ferric-chelate reductase (NADPH) activity [GO:0052851]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network transport vesicle [GO:0030140]; cupric reductase activity [GO:0008823]; ferric-chelate reductase (NADPH) activity [GO:0052851]; metal ion binding [GO:0046872]; copper ion import [GO:0015677]; copper ion import across plasma membrane [GO:0098705]; endocytosis [GO:0006897]; Golgi to plasma membrane transport [GO:0006893]; iron ion import across plasma membrane [GO:0098711]; regulated exocytosis [GO:0045055]; response to hormone [GO:0009725]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q8BWB6}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:12429817}; Multi-pass membrane protein {ECO:0000255}.
Q8NFT6	reviewed	DBF4B_HUMAN	Protein DBF4 homolog B (Activator of S phase kinase-like protein 1) (ASK-like protein 1) (Chiffon homolog B) (Dbf4-related factor 1)	DBF4B ASKL1 DRF1	Homo sapiens (Human)	615	FUNCTION: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:15668232, ECO:0000269|PubMed:17062569}.		cell cycle [GO:0007049]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; regulation of cell cycle phase transition [GO:1901987]	cytoplasm [GO:0005737]; Dbf4-dependent protein kinase complex [GO:0031431]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nucleic acid binding [GO:0003676]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; Dbf4-dependent protein kinase complex [GO:0031431]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; regulation of cell cycle phase transition [GO:1901987]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:15668232}. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.
Q8NFT8	reviewed	DNER_HUMAN	Delta and Notch-like epidermal growth factor-related receptor	DNER BET UNQ262/PRO299	Homo sapiens (Human)	737	FUNCTION: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). {ECO:0000250}.		central nervous system development [GO:0007417]; endocytosis [GO:0006897]; glial cell differentiation [GO:0010001]; neuron migration [GO:0001764]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; skeletal muscle fiber development [GO:0048741]; synapse assembly [GO:0007416]	dendrite [GO:0030425]; early endosome [GO:0005769]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; clathrin binding [GO:0030276]; Notch binding [GO:0005112]; transmembrane signaling receptor activity [GO:0004888]	dendrite [GO:0030425]; early endosome [GO:0005769]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; clathrin binding [GO:0030276]; Notch binding [GO:0005112]; transmembrane signaling receptor activity [GO:0004888]; central nervous system development [GO:0007417]; endocytosis [GO:0006897]; glial cell differentiation [GO:0010001]; neuron migration [GO:0001764]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; skeletal muscle fiber development [GO:0048741]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity). {ECO:0000250}.
Q8NFU1	reviewed	BEST2_HUMAN	Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1)	BEST2 VMD2L1	Homo sapiens (Human)	509	FUNCTION: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. {ECO:0000269|PubMed:11904445, ECO:0000269|PubMed:12907679, ECO:0000269|PubMed:18400985}.		membrane depolarization [GO:0051899]; sensory perception of smell [GO:0007608]	chloride channel complex [GO:0034707]; cilium [GO:0005929]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]	chloride channel complex [GO:0034707]; cilium [GO:0005929]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; membrane depolarization [GO:0051899]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NFU3	reviewed	TSTD1_HUMAN	Thiosulfate:glutathione sulfurtransferase (TST) (EC 2.8.1.-)	TSTD1 KAT	Homo sapiens (Human)	115	FUNCTION: Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). {ECO:0000269|PubMed:24981631}.		glucose metabolic process [GO:0006006]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; sequence-specific DNA binding [GO:0043565]; thiosulfate-thiol sulfurtransferase activity [GO:0050337]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; sequence-specific DNA binding [GO:0043565]; thiosulfate-thiol sulfurtransferase activity [GO:0050337]; glucose metabolic process [GO:0006006]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12817473}. Note=Localized around the nuclear membranes.
Q8NFU5	reviewed	IPMK_HUMAN	Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)	IPMK IMPK	Homo sapiens (Human)	416	FUNCTION: Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:30420721, PubMed:28882892). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). {ECO:0000250|UniProtKB:Q7TT16, ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481, ECO:0000269|PubMed:28882892, ECO:0000269|PubMed:29883610, ECO:0000269|PubMed:30420721, ECO:0000269|PubMed:30624931}.		inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; inositol trisphosphate metabolic process [GO:0032957]; necroptotic process [GO:0070266]; phosphatidylinositol metabolic process [GO:0046488]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; ATP binding [GO:0005524]; flavonoid binding [GO:0097243]; inositol tetrakisphosphate 3-kinase activity [GO:0000824]; inositol tetrakisphosphate 5-kinase activity [GO:0047326]; inositol tetrakisphosphate 6-kinase activity [GO:0000825]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]; inositol-1,4,5-trisphosphate 6-kinase activity [GO:0000823]; metal ion binding [GO:0046872]; myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity [GO:0102732]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; ATP binding [GO:0005524]; flavonoid binding [GO:0097243]; inositol tetrakisphosphate 3-kinase activity [GO:0000824]; inositol tetrakisphosphate 5-kinase activity [GO:0047326]; inositol tetrakisphosphate 6-kinase activity [GO:0000825]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]; inositol-1,4,5-trisphosphate 6-kinase activity [GO:0000823]; metal ion binding [GO:0046872]; myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity [GO:0102732]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; inositol trisphosphate metabolic process [GO:0032957]; necroptotic process [GO:0070266]; phosphatidylinositol metabolic process [GO:0046488]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12027805}.
Q8NFU7	reviewed	TET1_HUMAN	Methylcytosine dioxygenase TET1 (EC 1.14.11.80) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein)	TET1 CXXC6 KIAA1676 LCX	Homo sapiens (Human)	2136	FUNCTION: Dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (PubMed:19372391, PubMed:21496894, PubMed:21778364, PubMed:35798741). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes, including stem cell maintenance, T- and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells and plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Together with QSER1, plays an essential role in the protection and maintenance of transcriptional and developmental programs to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). May play a role in pancreatic beta-cell specification during development. In this context, may function as an upstream epigenetic regulator of PAX4 presumably through direct recruitment by FOXA2 to a PAX4 enhancer to preserve its unmethylated status, thereby potentiating PAX4 expression to adopt beta-cell fate during endocrine lineage commitment (PubMed:35798741). Under DNA hypomethylation conditions, such as in female meiotic germ cells, may induce epigenetic reprogramming of pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions. PCH forms chromocenters in the interphase nucleus and chromocenters cluster at the prophase of meiosis. In this context, may also be essential for chromocenter clustering in a catalytic activity-independent manner, possibly through the recruitment polycomb repressive complex 1 (PRC1) to the chromocenters (By similarity). During embryonic development, may be required for normal meiotic progression in oocytes and meiotic gene activation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:12124344, ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:31278917, ECO:0000269|PubMed:33833093, ECO:0000269|PubMed:35798741}.; FUNCTION: [Isoform 1]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). Binds to promoters, particularly to those with high CG content (By similarity). In hippocampal neurons, isoform 1 regulates the expression of a unique subset of genes compared to isoform 2, although some overlap exists between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 1 controls both miniature excitatory postsynaptic current amplitude and frequency (By similarity). Isoform 1 may regulate genes involved in hippocampal-dependent memory, leading to positive regulation of memory, contrary to isoform 2 that may decrease memory (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}.; FUNCTION: [Isoform 2]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). As isoform 1, binds to promoters, particularly to those with high CG content, however displays reduced global chromatin affinity compared with isoform 1, leading to decreased global DNA demethylation compared with isoform 1 (By similarity). Contrary to isoform 1, isoform 2 localizes during S phase to sites of ongoing DNA replication in heterochromatin, causing a significant de novo 5hmC formation, globally, and more so in heterochromatin, including LINE 1 interspersed DNA repeats leading to their activation (By similarity). In hippocampal neurons, isoform 2 regulates the expression of a unique subset of genes compared to isoform 1, although some overlap between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 2 controls miniature excitatory postsynaptic current frequency, but not amplitude (By similarity). Isoform 2 may regulate genes involved in hippocampal-dependent memory, leading to negative regulation of memory, contrary to isoform 1 that may improve memory (By similarity). In immature and partially differentiated gonadotrope cells, directly represses luteinizing hormone gene LHB expression and does not catalyze 5hmC at the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000305|PubMed:36056023}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing. {ECO:0000305|Ref.2}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing. {ECO:0000305|Ref.2}.	5-methylcytosine catabolic process [GO:0006211]; chromatin remodeling [GO:0006338]; DNA demethylation [GO:0080111]; inner cell mass cell differentiation [GO:0001826]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA methylation-dependent heterochromatin formation [GO:0090310]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]; stem cell population maintenance [GO:0019827]	nucleus [GO:0005634]; Sin3 complex [GO:0016580]	DNA binding [GO:0003677]; iron ion binding [GO:0005506]; methyl-CpG binding [GO:0008327]; methylcytosine dioxygenase activity [GO:0070579]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; Sin3 complex [GO:0016580]; DNA binding [GO:0003677]; iron ion binding [GO:0005506]; methyl-CpG binding [GO:0008327]; methylcytosine dioxygenase activity [GO:0070579]; zinc ion binding [GO:0008270]; 5-methylcytosine catabolic process [GO:0006211]; chromatin remodeling [GO:0006338]; DNA demethylation [GO:0080111]; inner cell mass cell differentiation [GO:0001826]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA methylation-dependent heterochromatin formation [GO:0090310]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3URK3}. Chromosome {ECO:0000269|PubMed:33833093}. Note=Localization to chromatin is promoted by monoubiquitination on Lys-1589. {ECO:0000269|PubMed:25557551}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:36056023}. Chromosome {ECO:0000250|UniProtKB:Q3URK3}. Note=Contrary to isoform 2, which accumulates at sites of ongoing DNA replication in heterochromatin, isoform 1 shows a homogenous nuclear pattern during mitotic S phase. {ECO:0000250|UniProtKB:Q3URK3}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:36056023}. Chromosome {ECO:0000250|UniProtKB:Q3URK3}. Note=During DNA replication, localizes to sites of ongoing DNA replication in heterochromatin (in late S phase) in an UHRF1- and CRL4(VprBP)-dependent manner, as a consequence of ubiquitination of the conserved residue Lys-1589. Localization to heterochromatin is independent of catalytic activity. {ECO:0000269|PubMed:36056023}.
Q8NFV4	reviewed	ABHDB_HUMAN	Protein ABHD11 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 11) (Abhydrolase domain-containing protein 11) (Williams-Beuren syndrome chromosomal region 21 protein)	ABHD11 WBSCR21 PP1226	Homo sapiens (Human)	315			cellular lipid metabolic process [GO:0044255]	mitochondrion [GO:0005739]	carboxylic ester hydrolase activity [GO:0052689]	mitochondrion [GO:0005739]; carboxylic ester hydrolase activity [GO:0052689]; cellular lipid metabolic process [GO:0044255]	
Q8NFW1	reviewed	COMA1_HUMAN	Collagen alpha-1(XXII) chain	COL22A1	Homo sapiens (Human)	1626	FUNCTION: Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts.		extracellular matrix organization [GO:0030198]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Cytoplasm {ECO:0000250}.
Q8NFW5	reviewed	DMBX1_HUMAN	Diencephalon/mesencephalon homeobox protein 1 (Orthodenticle homolog 3) (Paired-like homeobox protein DMBX1)	DMBX1 MBX OTX3 PAXB	Homo sapiens (Human)	382	FUNCTION: Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity). {ECO:0000250}.		adult feeding behavior [GO:0008343]; adult locomotory behavior [GO:0008344]; brain development [GO:0007420]; central nervous system development [GO:0007417]; developmental growth [GO:0048589]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; adult feeding behavior [GO:0008343]; adult locomotory behavior [GO:0008344]; brain development [GO:0007420]; central nervous system development [GO:0007417]; developmental growth [GO:0048589]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O35137, ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Q8NFW8	reviewed	NEUA_HUMAN	N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase)	CMAS	Homo sapiens (Human)	434	FUNCTION: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).		N-acetylneuraminate metabolic process [GO:0006054]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	N-acylneuraminate cytidylyltransferase activity [GO:0008781]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; N-acylneuraminate cytidylyltransferase activity [GO:0008781]; N-acetylneuraminate metabolic process [GO:0006054]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11602804}.
Q8NFW9	reviewed	MYRIP_HUMAN	Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c)	MYRIP SLAC2C	Homo sapiens (Human)	859	FUNCTION: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}.		intracellular protein transport [GO:0006886]; positive regulation of insulin secretion [GO:0032024]	cortical actin cytoskeleton [GO:0030864]; dense core granule [GO:0031045]; exocyst [GO:0000145]; melanosome [GO:0042470]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor outer segment [GO:0001750]; synapse [GO:0045202]; transport vesicle [GO:0030133]	actin binding [GO:0003779]; myosin binding [GO:0017022]; protein kinase A binding [GO:0051018]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]	cortical actin cytoskeleton [GO:0030864]; dense core granule [GO:0031045]; exocyst [GO:0000145]; melanosome [GO:0042470]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor outer segment [GO:0001750]; synapse [GO:0045202]; transport vesicle [GO:0030133]; actin binding [GO:0003779]; myosin binding [GO:0017022]; protein kinase A binding [GO:0051018]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]; intracellular protein transport [GO:0006886]; positive regulation of insulin secretion [GO:0032024]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8K3I4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TNY7}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q7TNY7}. Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments. {ECO:0000250|UniProtKB:Q7TNY7}.
Q8NFX7	reviewed	STXB6_HUMAN	Syntaxin-binding protein 6 (Amisyn)	STXBP6 HSPC156	Homo sapiens (Human)	210	FUNCTION: Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to an intron retention. {ECO:0000305}.	negative regulation of exocytosis [GO:0045920]; regulation of SNARE complex assembly [GO:0035542]; SNARE complex assembly [GO:0035493]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; membrane [GO:0016020]	cadherin binding involved in cell-cell adhesion [GO:0098641]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; membrane [GO:0016020]; cadherin binding involved in cell-cell adhesion [GO:0098641]; negative regulation of exocytosis [GO:0045920]; regulation of SNARE complex assembly [GO:0035542]; SNARE complex assembly [GO:0035493]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12145319}. Membrane {ECO:0000269|PubMed:12145319}; Peripheral membrane protein {ECO:0000269|PubMed:12145319}.
Q8NFY4	reviewed	SEM6D_HUMAN	Semaphorin-6D	SEMA6D KIAA1479	Homo sapiens (Human)	1073	FUNCTION: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.		axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of smooth muscle cell migration [GO:0014912]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of smooth muscle cell migration [GO:0014911]; semaphorin-plexin signaling pathway [GO:0071526]; smooth muscle cell migration [GO:0014909]; ventricular system development [GO:0021591]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of smooth muscle cell migration [GO:0014912]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of smooth muscle cell migration [GO:0014911]; semaphorin-plexin signaling pathway [GO:0071526]; smooth muscle cell migration [GO:0014909]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm.
Q8NFY9	reviewed	KBTB8_HUMAN	Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP)	KBTBD8 KIAA1842 TAKRP	Homo sapiens (Human)	601	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:26399832}.		neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; protein monoubiquitination [GO:0006513]; regulation of translation [GO:0006417]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; spindle [GO:0005819]		Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; spindle [GO:0005819]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; protein monoubiquitination [GO:0006513]; regulation of translation [GO:0006417]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23578279}. Golgi apparatus {ECO:0000269|PubMed:23578279}. Note=Translocates to the spindle apparatus during mitosis. {ECO:0000269|PubMed:23578279}.
Q8NFZ0	reviewed	FBH1_HUMAN	F-box DNA helicase 1 (hFBH1) (EC 5.6.2.4) (DNA 3'-5' helicase 1) (F-box only protein 18)	FBH1 FBX18 FBXO18	Homo sapiens (Human)	1043	FUNCTION: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578). {ECO:0000269|PubMed:11956208, ECO:0000269|PubMed:17724085, ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23319600, ECO:0000269|PubMed:23361013, ECO:0000269|PubMed:25585578, ECO:0000269|PubMed:25772361}.		DNA catabolic process [GO:0006308]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; replication fork processing [GO:0031297]; response to intra-S DNA damage checkpoint signaling [GO:0072429]	chromatin [GO:0000785]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; double-stranded DNA binding [GO:0003690]; isomerase activity [GO:0016853]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; double-stranded DNA binding [GO:0003690]; isomerase activity [GO:0016853]; single-stranded DNA binding [GO:0003697]; DNA catabolic process [GO:0006308]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; replication fork processing [GO:0031297]; response to intra-S DNA damage checkpoint signaling [GO:0072429]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23677613}. Chromosome {ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23319600, ECO:0000269|PubMed:23677613}. Note=Accumulates at sites of DNA damage or replication stress (PubMed:19736316, PubMed:23677613). PCNA is required for localization to DNA damage sites (PubMed:23677613). Localizes to the nucleoplasm in absence of DNA damage (PubMed:23677613). {ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23677613}.
Q8NFZ3	reviewed	NLGNY_HUMAN	Neuroligin-4, Y-linked (Neuroligin Y)	NLGN4Y KIAA0951	Homo sapiens (Human)	816	FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. {ECO:0000250|UniProtKB:Q8N0W4}.		chemical synaptic transmission [GO:0007268]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; social behavior [GO:0035176]; synaptic vesicle endocytosis [GO:0048488]; vocalization behavior [GO:0071625]	asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]	cell adhesion molecule binding [GO:0050839]; neurexin family protein binding [GO:0042043]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]	asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]; cell adhesion molecule binding [GO:0050839]; neurexin family protein binding [GO:0042043]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]; chemical synaptic transmission [GO:0007268]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; social behavior [GO:0035176]; synaptic vesicle endocytosis [GO:0048488]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Postsynaptic density membrane {ECO:0000250}.
Q8NFZ4	reviewed	NLGN2_HUMAN	Neuroligin-2	NLGN2 KIAA1366	Homo sapiens (Human)	835	FUNCTION: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q69ZK9}.		cell-cell adhesion [GO:0098609]; cell-cell junction maintenance [GO:0045217]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; inhibitory synapse assembly [GO:1904862]; insulin metabolic process [GO:1901142]; jump response [GO:0007630]; locomotory exploration behavior [GO:0035641]; modulation of chemical synaptic transmission [GO:0050804]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter-gated ion channel clustering [GO:0072578]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle clustering [GO:2000809]; positive regulation of t-SNARE clustering [GO:1904034]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein localization to cell surface [GO:0034394]; protein localization to synapse [GO:0035418]; regulation of AMPA receptor activity [GO:2000311]; regulation of presynapse assembly [GO:1905606]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; sensory perception of pain [GO:0019233]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic transmission, GABAergic [GO:0051932]; synaptic vesicle endocytosis [GO:0048488]; terminal button organization [GO:0072553]; thigmotaxis [GO:0001966]	cell surface [GO:0009986]; dendritic shaft [GO:0043198]; dopaminergic synapse [GO:0098691]; excitatory synapse [GO:0060076]; glycinergic synapse [GO:0098690]; inhibitory synapse [GO:0060077]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; ribbon synapse [GO:0097470]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]	cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; neurexin family protein binding [GO:0042043]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; dendritic shaft [GO:0043198]; dopaminergic synapse [GO:0098691]; excitatory synapse [GO:0060076]; glycinergic synapse [GO:0098690]; inhibitory synapse [GO:0060077]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; ribbon synapse [GO:0097470]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; neurexin family protein binding [GO:0042043]; signaling receptor activity [GO:0038023]; cell-cell adhesion [GO:0098609]; cell-cell junction maintenance [GO:0045217]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; inhibitory synapse assembly [GO:1904862]; insulin metabolic process [GO:1901142]; jump response [GO:0007630]; locomotory exploration behavior [GO:0035641]; modulation of chemical synaptic transmission [GO:0050804]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter-gated ion channel clustering [GO:0072578]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle clustering [GO:2000809]; positive regulation of t-SNARE clustering [GO:1904034]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein localization to cell surface [GO:0034394]; protein localization to synapse [GO:0035418]; regulation of AMPA receptor activity [GO:2000311]; regulation of presynapse assembly [GO:1905606]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; sensory perception of pain [GO:0019233]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic transmission, GABAergic [GO:0051932]; synaptic vesicle endocytosis [GO:0048488]; terminal button organization [GO:0072553]; thigmotaxis [GO:0001966]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}. Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity). {ECO:0000250}.
Q8NFZ5	reviewed	TNIP2_HUMAN	TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein)	TNIP2 ABIN2 FLIP1	Homo sapiens (Human)	429	FUNCTION: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:11389905, ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}.		apoptotic process [GO:0006915]; CD40 signaling pathway [GO:0023035]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; negative regulation of endothelial cell apoptotic process [GO:2000352]; positive regulation of B cell activation [GO:0050871]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macrophage activation [GO:0043032]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 9 signaling pathway [GO:0034162]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein kinase binding [GO:0019901]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein kinase binding [GO:0019901]; apoptotic process [GO:0006915]; CD40 signaling pathway [GO:0023035]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; negative regulation of endothelial cell apoptotic process [GO:2000352]; positive regulation of B cell activation [GO:0050871]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macrophage activation [GO:0043032]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 9 signaling pathway [GO:0034162]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12595760}. Nucleus {ECO:0000305}.
Q8NFZ8	reviewed	CADM4_HUMAN	Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2)	CADM4 IGSF4C NECL4 TSLL2	Homo sapiens (Human)	388	FUNCTION: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity. {ECO:0000269|PubMed:16261159}.		homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; regulation of cell motility [GO:2000145]; regulation of cell population proliferation [GO:0042127]; regulation of protein phosphorylation [GO:0001932]; regulation of Rac protein signal transduction [GO:0035020]; regulation of wound healing [GO:0061041]	cell leading edge [GO:0031252]; cell-cell contact zone [GO:0044291]; membrane [GO:0016020]	protein phosphatase binding [GO:0019903]; receptor tyrosine kinase binding [GO:0030971]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; vascular endothelial growth factor receptor 2 binding [GO:0043184]	cell leading edge [GO:0031252]; cell-cell contact zone [GO:0044291]; membrane [GO:0016020]; protein phosphatase binding [GO:0019903]; receptor tyrosine kinase binding [GO:0030971]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; regulation of cell motility [GO:2000145]; regulation of cell population proliferation [GO:0042127]; regulation of protein phosphorylation [GO:0001932]; regulation of Rac protein signal transduction [GO:0035020]; regulation of wound healing [GO:0061041]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8NG06	reviewed	TRI58_HUMAN	E3 ubiquitin-protein ligase TRIM58 (EC 2.3.2.27) (Protein BIA2) (RING-type E3 ubiquitin transferase TRIM58) (Tripartite motif-containing protein 58)	TRIM58	Homo sapiens (Human)	486	FUNCTION: E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. {ECO:0000269|PubMed:25241935}.		innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of erythrocyte enucleation [GO:0061931]; protein ubiquitination [GO:0016567]; regulation of nuclear migration along microtubule [GO:1902838]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	dynein heavy chain binding [GO:0045504]; dynein intermediate chain binding [GO:0045505]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; dynein heavy chain binding [GO:0045504]; dynein intermediate chain binding [GO:0045505]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of erythrocyte enucleation [GO:0061931]; protein ubiquitination [GO:0016567]; regulation of nuclear migration along microtubule [GO:1902838]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q8NG08	reviewed	HELB_HUMAN	DNA helicase B (hDHB) (EC 3.6.4.12)	HELB	Homo sapiens (Human)	1087	FUNCTION: 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). {ECO:0000269|PubMed:12181327, ECO:0000269|PubMed:22194613, ECO:0000269|PubMed:25617833, ECO:0000269|PubMed:26774285}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication, synthesis of RNA primer [GO:0006269]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA double-strand break processing [GO:1903775]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein-containing complex binding [GO:0044877]; single-stranded DNA helicase activity [GO:0017116]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein-containing complex binding [GO:0044877]; single-stranded DNA helicase activity [GO:0017116]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication, synthesis of RNA primer [GO:0006269]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA double-strand break processing [GO:1903775]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15146062}. Cytoplasm {ECO:0000269|PubMed:15146062}. Chromosome {ECO:0000269|PubMed:26774285}. Note=Predominantly nuclear (PubMed:15146062). Phosphorylation at Ser-967 by CDK2 during the G1/S transition results in its nuclear export into the cytoplasm as cells approach and progress through S phase (PubMed:15146062). Following DNA damage, recruited to sites of double-strand breaks by the RPA complex (PubMed:26774285). Recruited to chromatin following DNA damage induced by UV irradiation, or camptothecin or hydroxyurea treatment (PubMed:22194613). {ECO:0000269|PubMed:15146062, ECO:0000269|PubMed:22194613, ECO:0000269|PubMed:26774285}.
Q8NG11	reviewed	TSN14_HUMAN	Tetraspanin-14 (Tspan-14) (DC-TM4F2) (Transmembrane 4 superfamily member 14)	TSPAN14 TM4SF14	Homo sapiens (Human)	270	FUNCTION: Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). {ECO:0000250|UniProtKB:Q8QZY6, ECO:0000269|PubMed:23035126, ECO:0000269|PubMed:26668317, ECO:0000269|PubMed:26686862}.		positive regulation of Notch signaling pathway [GO:0045747]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; tetraspanin-enriched microdomain [GO:0097197]	enzyme binding [GO:0019899]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; tetraspanin-enriched microdomain [GO:0097197]; enzyme binding [GO:0019899]; positive regulation of Notch signaling pathway [GO:0045747]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862}; Multi-pass membrane protein {ECO:0000305}.
Q8NG27	reviewed	PJA1_HUMAN	E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1)	PJA1 RNF70	Homo sapiens (Human)	643	FUNCTION: Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. {ECO:0000250, ECO:0000269|PubMed:12036302}.	MISCELLANEOUS: [Isoform 2]: PubMed:12036302 reported that isoform 2 arises by alternative initiation. {ECO:0000305}.	protein catabolic process [GO:0030163]	cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein catabolic process [GO:0030163]	
Q8NG31	reviewed	KNL1_HUMAN	Kinetochore scaffold 1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14)	KNL1 CASC5 KIAA1570	Homo sapiens (Human)	2342	FUNCTION: Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986}.		acrosome assembly [GO:0001675]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; protein localization to kinetochore [GO:0034501]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; kinetochore [GO:0000776]; Knl1/Spc105 complex [GO:0180019]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; kinetochore [GO:0000776]; Knl1/Spc105 complex [GO:0180019]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; acrosome assembly [GO:0001675]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; protein localization to kinetochore [GO:0034501]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle.
Q8NG50	reviewed	RDM1_HUMAN	RAD52 motif-containing protein 1 (RAD52 homolog B)	RDM1 RAD52B	Homo sapiens (Human)	284	FUNCTION: May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA. {ECO:0000269|PubMed:15611051}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative splicing of isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Produced by alternative splicing of isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 10]: Produced by alternative splicing of isoform 1. In cells exposed to a mild heat schock. {ECO:0000305}.; MISCELLANEOUS: [Isoform 11]: Produced by alternative splicing of isoform 2. In cells exposed to a mild heat schock. {ECO:0000305}.		Cajal body [GO:0015030]; cytosol [GO:0005829]; nucleolus [GO:0005730]; PML body [GO:0016605]	DNA binding [GO:0003677]; RNA binding [GO:0003723]	Cajal body [GO:0015030]; cytosol [GO:0005829]; nucleolus [GO:0005730]; PML body [GO:0016605]; DNA binding [GO:0003677]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17905820}. Cytoplasm {ECO:0000269|PubMed:17905820}. Nucleus, nucleolus {ECO:0000269|PubMed:17905820}. Note=Isoform 3 and isoform 10 are predominantly nuclear and nucleolar. After treatment with proteasomal inhibitors and mild heat-shock stress, isoform 1, isoform 3, isoform 5, isoform 7, isoform 8 and isoform 10 are relocalized to the nucleolus as dot-like or irregular subnuclear structures. Isoform 1 colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress. Isoform 3, but not isoform 1 and isoform 5, is relocalized in nucleolar caps during transcriptional arrest.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus, PML body. Nucleus, Cajal body. Note=Isoform 1 is predominantly cytoplasmic. Isoform 1 colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress.
Q8NG66	reviewed	NEK11_HUMAN	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11)	NEK11	Homo sapiens (Human)	645	FUNCTION: Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}.		intracellular signal transduction [GO:0035556]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle phase transition [GO:1901990]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle phase transition [GO:1901990]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12154088}. Nucleus, nucleolus {ECO:0000269|PubMed:15161910}. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase (PubMed:12154088). Accumulates in the nucleolus in G1/S-arrested cells (PubMed:15161910). {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:15161910}.
Q8NG98	reviewed	OR7D4_HUMAN	Olfactory receptor 7D4 (OR19-B) (Odorant receptor family subfamily D member 4RT) (Olfactory receptor OR19-7)	OR7D4 OR7D4P	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHC4	reviewed	O10J5_HUMAN	Olfactory receptor 10J5 (Olfactory receptor OR1-28)	OR10J5	Homo sapiens (Human)	309	FUNCTION: Olfactory receptor. Activated by the synthetic floral odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of cedarwood oil. Its activation increases intracellular Ca(2+) (PubMed:25791473, PubMed:28842679). Acts as a key regulator of myogenesis through its actions on cell migration and adhesion by activating the Ca(2+)-dependent AKT signal transduction pathway (By similarity). Acts also as a regulator of angiogenesis (PubMed:25791473). Moreover, plays a role in the regulation of lipid accumulation in hepatocytes via the cAMP-PKA pathway (PubMed:28842679). May be involved in sperm chemotaxis and motility (By similarity). {ECO:0000250|UniProtKB:Q62007, ECO:0000269|PubMed:25791473, ECO:0000269|PubMed:28842679}.		angiogenesis [GO:0001525]; chemotaxis [GO:0006935]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; lipid homeostasis [GO:0055088]; muscle organ development [GO:0007517]; regulation of angiogenesis [GO:0045765]; regulation of muscle cell differentiation [GO:0051147]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; angiogenesis [GO:0001525]; chemotaxis [GO:0006935]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; lipid homeostasis [GO:0055088]; muscle organ development [GO:0007517]; regulation of angiogenesis [GO:0045765]; regulation of muscle cell differentiation [GO:0051147]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28842679}; Multi-pass membrane protein {ECO:0000255}.
Q8NHE4	reviewed	VA0E2_HUMAN	V-type proton ATPase subunit e 2 (V-ATPase subunit e 2) (Lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2) (Vacuolar proton pump subunit e 2)	ATP6V0E2 ATP6V0E2L C7orf32	Homo sapiens (Human)	81	FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). {ECO:0000250|UniProtKB:Q2KIB5}.	MISCELLANEOUS: [Isoform 3]: May be due to a competing donor splice site. {ECO:0000305}.	proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; transmembrane transport [GO:0055085]; vacuolar acidification [GO:0007035]	clathrin-coated vesicle membrane [GO:0030665]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	ATPase-coupled ion transmembrane transporter activity [GO:0042625]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	clathrin-coated vesicle membrane [GO:0030665]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; ATPase-coupled ion transmembrane transporter activity [GO:0042625]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; transmembrane transport [GO:0055085]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q5EB76}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q5EB76}; Multi-pass membrane protein {ECO:0000255}.
Q8NHG7	reviewed	SVIP_HUMAN	Small VCP/p97-interacting protein	SVIP	Homo sapiens (Human)	77			negative regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903070]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly [GO:1904240]; positive regulation of autophagy [GO:0010508]; positive regulation of protein lipidation [GO:1903061]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; smooth endoplasmic reticulum membrane [GO:0030868]; tertiary granule membrane [GO:0070821]	ATPase binding [GO:0051117]; protein self-association [GO:0043621]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; smooth endoplasmic reticulum membrane [GO:0030868]; tertiary granule membrane [GO:0070821]; ATPase binding [GO:0051117]; protein self-association [GO:0043621]; negative regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903070]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly [GO:1904240]; positive regulation of autophagy [GO:0010508]; positive regulation of protein lipidation [GO:1903061]	SUBCELLULAR LOCATION: Smooth endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Q8NHG8	reviewed	ZNRF2_HUMAN	E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)	ZNRF2 RNF202	Homo sapiens (Human)	242	FUNCTION: E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Lysosome membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Presynaptic cell membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Cytoplasm {ECO:0000269|PubMed:27244671}.
Q8NHH1	reviewed	TTL11_HUMAN	Tubulin polyglutamylase TTLL11 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 11)	TTLL11 C9orf20	Homo sapiens (Human)	800	FUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent polyglutamate long side-chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions (By similarity). {ECO:0000250|UniProtKB:A4Q9F4, ECO:0000269|PubMed:22493317}.		microtubule cytoskeleton organization [GO:0000226]; microtubule severing [GO:0051013]; protein modification process [GO:0036211]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]; microtubule cytoskeleton organization [GO:0000226]; microtubule severing [GO:0051013]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A4Q9F4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A4Q9F4}.
Q8NHH9	reviewed	ATLA2_HUMAN	Atlastin-2 (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) (ARL-6-interacting protein 2) (Aip-2)	ATL2 ARL6IP2	Homo sapiens (Human)	583	FUNCTION: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977). {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:27619977}.		endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; Golgi organization [GO:0007030]; protein homooligomerization [GO:0051260]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum tubular network membrane [GO:0098826]; membrane [GO:0016020]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum tubular network membrane [GO:0098826]; membrane [GO:0016020]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; Golgi organization [GO:0007030]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:27619977}; Multi-pass membrane protein {ECO:0000269|PubMed:18270207}. Note=Localizes at endoplasmic reticulum (ER) three-way tubular junctions (PubMed:27619977). {ECO:0000269|PubMed:27619977}.
Q8NHJ6	reviewed	LIRB4_HUMAN	Leukocyte immunoglobulin-like receptor subfamily B member 4 (B4) (CD85 antigen-like family member K) (Immunoglobulin-like transcript 3) (ILT-3) (Leukocyte immunoglobulin-like receptor 5) (LIR-5) (Monocyte inhibitory receptor HM18) (CD antigen CD85k)	LILRB4 ILT3 LIR5	Homo sapiens (Human)	448	FUNCTION: Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462). Receptor for FN1 (PubMed:34089617). Receptor for apolipoprotein APOE (PubMed:30333625). Receptor for ALCAM/CD166 (PubMed:29263213). Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699). Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736). This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617). Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213). Induces up-regulation of CD86 on dendritic cells (PubMed:19860908). Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462). {ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:16493035, ECO:0000269|PubMed:19833736, ECO:0000269|PubMed:19860908, ECO:0000269|PubMed:29263213, ECO:0000269|PubMed:30333625, ECO:0000269|PubMed:34089617, ECO:0000269|PubMed:9151699}.	MISCELLANEOUS: Activated by APOE on acute myeloid leukemia (AML) cells which leads to suppression of T cell proliferation and promotion of AML cell migration and infiltration (PubMed:30333625). LILRB4 signaling on AML cells is mediated by PTPN11/SHP-2 (PubMed:30333625). {ECO:0000269|PubMed:30333625}.; MISCELLANEOUS: [Isoform 2]: Alternative use of an acceptor site. {ECO:0000305}.	adaptive immune response [GO:0002250]; cytokine-mediated signaling pathway [GO:0019221]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; interleukin-10-mediated signaling pathway [GO:0140105]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of chemokine production [GO:0032682]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of cytotoxic T cell differentiation [GO:0045584]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of IP-10 production [GO:0071659]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of monocyte activation [GO:0150102]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of T cell costimulation [GO:2000524]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell anergy [GO:0002669]; receptor internalization [GO:0031623]; tolerance induction [GO:0002507]	cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	apolipoprotein binding [GO:0034185]; fibronectin binding [GO:0001968]; inhibitory MHC class I receptor activity [GO:0032396]; protein phosphatase binding [GO:0019903]; signaling receptor inhibitor activity [GO:0030547]; transmembrane receptor protein tyrosine kinase inhibitor activity [GO:0030293]	cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; apolipoprotein binding [GO:0034185]; fibronectin binding [GO:0001968]; inhibitory MHC class I receptor activity [GO:0032396]; protein phosphatase binding [GO:0019903]; signaling receptor inhibitor activity [GO:0030547]; transmembrane receptor protein tyrosine kinase inhibitor activity [GO:0030293]; adaptive immune response [GO:0002250]; cytokine-mediated signaling pathway [GO:0019221]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; interleukin-10-mediated signaling pathway [GO:0140105]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of chemokine production [GO:0032682]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of cytotoxic T cell differentiation [GO:0045584]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of IP-10 production [GO:0071659]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of monocyte activation [GO:0150102]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of T cell costimulation [GO:2000524]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell anergy [GO:0002669]; receptor internalization [GO:0031623]; tolerance induction [GO:0002507]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19833736, ECO:0000269|PubMed:9151699}; Single-pass type I membrane protein {ECO:0000269|PubMed:9151699}. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment. {ECO:0000269|PubMed:9151699}.
Q8NHL6	reviewed	LIRB1_HUMAN	Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)	LILRB1 ILT2 LIR1 MIR7	Homo sapiens (Human)	650	FUNCTION: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:29262349, PubMed:19304799). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251). {ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:16455647, ECO:0000269|PubMed:19304799, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:28636952, ECO:0000269|PubMed:29262349, ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9842885}.	MISCELLANEOUS: [Isoform 5]: May act as dominant negative regulator and block the interaction between membrane-associated isoforms and HLA-class I. {ECO:0000269|PubMed:19658091}.	adaptive immune response [GO:0002250]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; dendritic cell differentiation [GO:0097028]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of cell cycle [GO:0045786]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of endocytosis [GO:0045806]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of mononuclear cell proliferation [GO:0032945]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of osteoclast development [GO:2001205]; negative regulation of serotonin secretion [GO:0014063]; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001189]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transforming growth factor beta production [GO:0071635]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of apoptotic process [GO:0043065]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gamma-delta T cell activation involved in immune response [GO:2001193]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; receptor internalization [GO:0031623]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T cell proliferation involved in immune response [GO:0002309]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	HLA-A specific inhibitory MHC class I receptor activity [GO:0030107]; HLA-B specific inhibitory MHC class I receptor activity [GO:0030109]; inhibitory MHC class I receptor activity [GO:0032396]; MHC class I protein binding [GO:0042288]; MHC class I receptor activity [GO:0032393]; MHC class Ib protein binding [GO:0023029]; MHC class Ib protein complex binding [GO:0023025]; MHC class Ib receptor activity [GO:0032394]; protein homodimerization activity [GO:0042803]; protein phosphatase 1 binding [GO:0008157]; SH2 domain binding [GO:0042169]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; HLA-A specific inhibitory MHC class I receptor activity [GO:0030107]; HLA-B specific inhibitory MHC class I receptor activity [GO:0030109]; inhibitory MHC class I receptor activity [GO:0032396]; MHC class I protein binding [GO:0042288]; MHC class I receptor activity [GO:0032393]; MHC class Ib protein binding [GO:0023029]; MHC class Ib protein complex binding [GO:0023025]; MHC class Ib receptor activity [GO:0032394]; protein homodimerization activity [GO:0042803]; protein phosphatase 1 binding [GO:0008157]; SH2 domain binding [GO:0042169]; adaptive immune response [GO:0002250]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; dendritic cell differentiation [GO:0097028]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of cell cycle [GO:0045786]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of endocytosis [GO:0045806]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of mononuclear cell proliferation [GO:0032945]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of osteoclast development [GO:2001205]; negative regulation of serotonin secretion [GO:0014063]; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001189]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transforming growth factor beta production [GO:0071635]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of apoptotic process [GO:0043065]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gamma-delta T cell activation involved in immune response [GO:2001193]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; receptor internalization [GO:0031623]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T cell proliferation involved in immune response [GO:0002309]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:29262349, ECO:0000305|PubMed:19658091}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000269|PubMed:19658091}.
Q8NHM5	reviewed	KDM2B_HUMAN	Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B)	KDM2B CXXC2 FBL10 FBXL10 JHDM1B NDY1 PCCX2	Homo sapiens (Human)	1336	FUNCTION: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}.		chromatin remodeling [GO:0006338]; embryonic camera-type eye morphogenesis [GO:0048596]; forebrain development [GO:0030900]; fourth ventricle development [GO:0021592]; hindbrain development [GO:0030902]; initiation of neural tube closure [GO:0021993]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; third ventricle development [GO:0021678]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]	DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; rRNA binding [GO:0019843]; transcription coregulator activity [GO:0003712]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; rRNA binding [GO:0019843]; transcription coregulator activity [GO:0003712]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]; chromatin remodeling [GO:0006338]; embryonic camera-type eye morphogenesis [GO:0048596]; forebrain development [GO:0030900]; fourth ventricle development [GO:0021592]; hindbrain development [GO:0030902]; initiation of neural tube closure [GO:0021993]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; third ventricle development [GO:0021678]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:17994099}. Nucleus {ECO:0000269|PubMed:26237645}. Chromosome {ECO:0000269|PubMed:26237645}.
Q8NHP1	reviewed	ARK74_HUMAN	Aflatoxin B1 aldehyde reductase member 4 (EC 1.-.-.-) (AFB1 aldehyde reductase 3) (AFB1-AR 3) (Aldoketoreductase 7-like)	AKR7L AFAR3 AKR7A4	Homo sapiens (Human)	331	FUNCTION: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity). {ECO:0000250}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	aldo-keto reductase (NADP) activity [GO:0004033]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; aldo-keto reductase (NADP) activity [GO:0004033]	
Q8NHP6	reviewed	MSPD2_HUMAN	Motile sperm domain-containing protein 2	MOSPD2	Homo sapiens (Human)	518	FUNCTION: Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventionnal- and phosphorylated-FFAT-containing organelle-bound proteins (PubMed:29858488, PubMed:35389430, PubMed:33124732). In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis (PubMed:35389430). The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs (PubMed:35389430). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892). {ECO:0000269|PubMed:28137892, ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:33124732, ECO:0000269|PubMed:35389430}.		chemotaxis [GO:0006935]; lipid droplet formation [GO:0140042]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of neutrophil chemotaxis [GO:0090023]; protein homooligomerization [GO:0051260]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; membrane [GO:0016020]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	FFAT motif binding [GO:0033149]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; membrane [GO:0016020]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; FFAT motif binding [GO:0033149]; chemotaxis [GO:0006935]; lipid droplet formation [GO:0140042]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of neutrophil chemotaxis [GO:0090023]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28137892, ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:35389430}; Single-pass type IV membrane protein {ECO:0000269|PubMed:29858488}. Note=Localization to contact sites involving the endoplasmic reticulum and several organelles is regulated by interaction with proteins containing FFAT motif (PubMed:29858488). Dynamically distributes between specific subdomains of the endoplasmic reticulum (ER): ER membranes in contact with lipid droplets (LDs) and the remainder of the ER (PubMed:35389430). {ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:35389430}.
Q8NHP8	reviewed	PLBL2_HUMAN	Putative phospholipase B-like 2 (EC 3.1.1.-) (76 kDa protein) (p76) (LAMA-like protein 2) (Lamina ancestor homolog 2) (Phospholipase B domain-containing protein 2) [Cleaved into: Putative phospholipase B-like 2 32 kDa form; Putative phospholipase B-like 2 45 kDa form]	PLBD2	Homo sapiens (Human)	589	FUNCTION: Putative phospholipase. {ECO:0000250}.		phospholipid catabolic process [GO:0009395]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]	phospholipase activity [GO:0004620]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; phospholipase activity [GO:0004620]; phospholipid catabolic process [GO:0009395]	SUBCELLULAR LOCATION: Lysosome lumen {ECO:0000269|PubMed:17105447}.
Q8NHQ1	reviewed	CEP70_HUMAN	Centrosomal protein of 70 kDa (Cep70) (p10-binding protein)	CEP70 BITE	Homo sapiens (Human)	597	FUNCTION: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.		cilium assembly [GO:0060271]; regulation of microtubule cytoskeleton organization [GO:0070507]	centrosome [GO:0005813]; cytosol [GO:0005829]	gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]	centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; cilium assembly [GO:0060271]; regulation of microtubule cytoskeleton organization [GO:0070507]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:21795687}. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis.
Q8NHQ9	reviewed	DDX55_HUMAN	ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55)	DDX55 KIAA1595	Homo sapiens (Human)	600	FUNCTION: Probable ATP-binding RNA helicase.			cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	
Q8NHS0	reviewed	DNJB8_HUMAN	DnaJ homolog subfamily B member 8	DNAJB8	Homo sapiens (Human)	232	FUNCTION: Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins. {ECO:0000269|PubMed:20159555}.		chaperone-mediated protein folding [GO:0061077]; negative regulation of inclusion body assembly [GO:0090084]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]; negative regulation of inclusion body assembly [GO:0090084]	
Q8NHS1	reviewed	CLDN2_HUMAN	Claudin domain-containing protein 2	CLDND2	Homo sapiens (Human)	167				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NHS3	reviewed	MFSD8_HUMAN	Major facilitator superfamily domain-containing protein 8 (Ceroid-lipofuscinosis neuronal protein 7)	MFSD8 CLN7	Homo sapiens (Human)	518	FUNCTION: Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions. {ECO:0000269|PubMed:34910516}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	autophagosome maturation [GO:0097352]; lysosome organization [GO:0007040]; neuron development [GO:0048666]; regulation of autophagy [GO:0010506]; regulation of lysosomal protein catabolic process [GO:1905165]; TORC1 signaling [GO:0038202]	endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]	chloride channel activity [GO:0005254]; fluoride channel activity [GO:0062054]; iodide transmembrane transporter activity [GO:0015111]	endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; chloride channel activity [GO:0005254]; fluoride channel activity [GO:0062054]; iodide transmembrane transporter activity [GO:0015111]; autophagosome maturation [GO:0097352]; lysosome organization [GO:0007040]; neuron development [GO:0048666]; regulation of autophagy [GO:0010506]; regulation of lysosomal protein catabolic process [GO:1905165]; TORC1 signaling [GO:0038202]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:34910516}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17564970, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:20406422, ECO:0000269|PubMed:34910516}; Multi-pass membrane protein {ECO:0000255}. Note=Sorting to lysosomes involves dileucine-based motif.
Q8NHS9	reviewed	SPT22_HUMAN	Spermatogenesis-associated protein 22 (Testis development protein NYD-SP20)	SPATA22	Homo sapiens (Human)	363	FUNCTION: Meiosis-specific protein required for homologous recombination in meiosis I. {ECO:0000250|UniProtKB:Q5SV06}.		fertilization [GO:0009566]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA repair synthesis [GO:0000711]; regulation of meiotic cell cycle [GO:0051445]; reproductive system development [GO:0061458]; spermatocyte division [GO:0048137]	chromosome [GO:0005694]		chromosome [GO:0005694]; fertilization [GO:0009566]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA repair synthesis [GO:0000711]; regulation of meiotic cell cycle [GO:0051445]; reproductive system development [GO:0061458]; spermatocyte division [GO:0048137]	SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q5SV06}. Note=Localizes on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on MEIOB. {ECO:0000250|UniProtKB:Q5SV06}.
Q8NHU3	reviewed	SMS2_HUMAN	Phosphatidylcholine:ceramide cholinephosphotransferase 2 (EC 2.7.8.27) (Sphingomyelin synthase 2)	SGMS2 SMS2	Homo sapiens (Human)	365	FUNCTION: Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane (PubMed:14685263, PubMed:17449912, PubMed:17982138, PubMed:18370930). Does not use free phosphorylcholine or CDP-choline as donors (PubMed:14685263). Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE) (PubMed:19454763). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:17449912, PubMed:17982138). To a lesser extent, plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (PubMed:18370930, PubMed:21980337). Required for normal bone matrix mineralization (PubMed:30779713). {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912, ECO:0000269|PubMed:17982138, ECO:0000269|PubMed:18370930, ECO:0000269|PubMed:19454763, ECO:0000269|PubMed:21980337, ECO:0000269|PubMed:30779713}.	MISCELLANEOUS: Overexpression of the human protein in mouse causes increased non-HDL-sphingomyelin and non-HDL cholesterol levels, decreased HDL-sphingomyelin and HDL-cholesterol levels and increases the atherogenic potential of non-HDL lipoprotein particles.	ceramide biosynthetic process [GO:0046513]; ceramide phosphoethanolamine biosynthetic process [GO:1905373]; phosphorylation [GO:0016310]; regulation of bone mineralization [GO:0030500]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ceramide cholinephosphotransferase activity [GO:0047493]; ceramide phosphoethanolamine synthase activity [GO:0002950]; kinase activity [GO:0016301]; sphingomyelin synthase activity [GO:0033188]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ceramide cholinephosphotransferase activity [GO:0047493]; ceramide phosphoethanolamine synthase activity [GO:0002950]; kinase activity [GO:0016301]; sphingomyelin synthase activity [GO:0033188]; ceramide biosynthetic process [GO:0046513]; ceramide phosphoethanolamine biosynthetic process [GO:1905373]; phosphorylation [GO:0016310]; regulation of bone mineralization [GO:0030500]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:30779713}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:18370930}; Multi-pass membrane protein {ECO:0000255}. Note=Primarily localized at the plasma membrane with a small fraction at the Golgi apparatus. {ECO:0000269|PubMed:14685263}.
Q8NHU6	reviewed	TDRD7_HUMAN	Tudor domain-containing protein 7 (PCTAIRE2-binding protein) (Tudor repeat associator with PCTAIRE-2) (Trap)	TDRD7 PCTAIRE2BP	Homo sapiens (Human)	1098	FUNCTION: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis. {ECO:0000269|PubMed:21436445}.		lens fiber cell differentiation [GO:0070306]; lens morphogenesis in camera-type eye [GO:0002089]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; post-transcriptional regulation of gene expression [GO:0010608]; spermatogenesis [GO:0007283]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186]; ribonucleoprotein granule [GO:0035770]	mRNA binding [GO:0003729]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186]; ribonucleoprotein granule [GO:0035770]; mRNA binding [GO:0003729]; lens fiber cell differentiation [GO:0070306]; lens morphogenesis in camera-type eye [GO:0002089]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; post-transcriptional regulation of gene expression [GO:0010608]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21436445}. Note=Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids (By similarity). {ECO:0000250}.
Q8NHV1	reviewed	GIMA7_HUMAN	GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7)	GIMAP7 IAN7	Homo sapiens (Human)	300	FUNCTION: The dimer has GTPase activity; the active site contains residues from both subunits. {ECO:0000269|PubMed:23454188}.		GTP metabolic process [GO:0046039]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; GTP metabolic process [GO:0046039]	SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:23454188}. Cytoplasm {ECO:0000269|PubMed:23454188}. Endoplasmic reticulum {ECO:0000269|PubMed:15474311}. Golgi apparatus {ECO:0000269|PubMed:15474311}. Note=Colocalizes with GIMAP2 on the surface of cytoplasmic lipid droplets.
Q8NHV4	reviewed	NEDD1_HUMAN	Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1)	NEDD1	Homo sapiens (Human)	660	FUNCTION: Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}.		cell division [GO:0051301]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]	apical part of cell [GO:0045177]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; spindle pole [GO:0000922]	gamma-tubulin binding [GO:0043015]	apical part of cell [GO:0045177]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; spindle pole [GO:0000922]; gamma-tubulin binding [GO:0043015]; cell division [GO:0051301]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:27137183}.
Q8NHV9	reviewed	RHXF1_HUMAN	Rhox homeobox family member 1 (Ovary-, testis- and epididymis-expressed gene protein) (Paired-like homeobox protein PEPP-1)	RHOXF1 OTEX PEPP1	Homo sapiens (Human)	184	FUNCTION: Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis. {ECO:0000269|PubMed:28171660}.		androgen receptor signaling pathway [GO:0030521]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; androgen receptor signaling pathway [GO:0030521]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11980563}.
Q8NHW3	reviewed	MAFA_HUMAN	Transcription factor MafA (Pancreatic beta-cell-specific transcriptional activator) (RIPE3b1 factor) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A)	MAFA	Homo sapiens (Human)	353	FUNCTION: Transcription factor that activates insulin gene expression (PubMed:15993959, PubMed:12011435). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959). Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498). {ECO:0000269|PubMed:12011435, ECO:0000269|PubMed:15993959, ECO:0000269|PubMed:23148532, ECO:0000269|PubMed:29339498}.		insulin secretion [GO:0030073]; nitric oxide mediated signal transduction [GO:0007263]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; insulin secretion [GO:0030073]; nitric oxide mediated signal transduction [GO:0007263]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12011435, ECO:0000269|PubMed:12917329}.
Q8NHW4	reviewed	CC4L_HUMAN	C-C motif chemokine 4-like (Lymphocyte activation gene 1 protein) (LAG-1) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Monocyte adherence-induced protein 5-alpha) (Small-inducible cytokine A4-like)	CCL4L1 CCL4L LAG1 SCYA4L1; CCL4L2 CCL4L SCYA4L2	Homo sapiens (Human)	92	FUNCTION: Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5. {ECO:0000269|PubMed:15240137}.		cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]	extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q8NHX9	reviewed	TPC2_HUMAN	Two pore channel protein 2 (Two pore calcium channel protein 2)	TPCN2 TPC2	Homo sapiens (Human)	752	FUNCTION: Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) (PubMed:19387438, PubMed:19620632, PubMed:20880839, PubMed:30860481, PubMed:32167471, PubMed:31825310, PubMed:23063126, PubMed:24776928, PubMed:23394946, PubMed:24502975). Localizes to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis. Is associated with a plethora of physiological processes, including mTOR-dependent nutrient sensing, skin pigmentation and autophagy (PubMed:32167471, PubMed:23394946, PubMed:18488028). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (PubMed:31825310, PubMed:32167471, PubMed:24502975). As calcium channel, it increases the pH in the lysosomal lumen, as sodium channel, it promotes lysosomal exocytosis (PubMed:31825310, PubMed:32167471). Plays a crucial role in endolysosomal trafficking in the endolysosomal degradation pathway and is potentially involved in the homeostatic control of many macromolecules and cell metabolites (By similarity) (PubMed:18488028, PubMed:19387438, PubMed:19620632, PubMed:20880839, PubMed:23063126, PubMed:23394946, PubMed:24502975, PubMed:24776928, PubMed:31825310, PubMed:32167471, PubMed:32679067). Also expressed in melanosomes of pigmented cells where mediates a Ca(2+) channel and/or PI(3,5)P2-activated melanosomal Na(+) channel to acidify pH and inhibit tyrosinase activity required for melanogenesis and pigmentation (PubMed:27140606). Unlike the voltage-dependent TPCN1, TPCN2 is voltage independent and can be activated solely by PI(3,5)P2 binding. In contrast, PI(4,5)P2, PI(3,4)P2, PI(3)P and PI(5)P have no obvious effect on channel activation (PubMed:30860481). {ECO:0000250|UniProtKB:Q8BWC0, ECO:0000269|PubMed:18488028, ECO:0000269|PubMed:19387438, ECO:0000269|PubMed:19620632, ECO:0000269|PubMed:20880839, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:23394946, ECO:0000269|PubMed:24502975, ECO:0000269|PubMed:24776928, ECO:0000269|PubMed:27140606, ECO:0000269|PubMed:30860481, ECO:0000269|PubMed:31825310, ECO:0000269|PubMed:32167471, ECO:0000269|PubMed:32679067}.; FUNCTION: (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. {ECO:0000269|PubMed:25722412}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC), by endocytosis. {ECO:0000269|PubMed:32221306}.		calcium-mediated signaling [GO:0019722]; endocytosis involved in viral entry into host cell [GO:0075509]; endosome to lysosome transport of low-density lipoprotein particle [GO:0090117]; intracellular calcium ion homeostasis [GO:0006874]; intracellular pH reduction [GO:0051452]; lysosome organization [GO:0007040]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of developmental pigmentation [GO:0048086]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of autophagy [GO:0010506]; regulation of exocytosis [GO:0017157]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to vitamin D [GO:0033280]; smooth muscle contraction [GO:0006939]; sodium ion transmembrane transport [GO:0035725]	cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]	calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity [GO:0097682]; ligand-gated sodium channel activity [GO:0015280]; NAADP-sensitive calcium-release channel activity [GO:0072345]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; protein kinase binding [GO:0019901]; voltage-gated calcium channel activity [GO:0005245]	cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity [GO:0097682]; ligand-gated sodium channel activity [GO:0015280]; NAADP-sensitive calcium-release channel activity [GO:0072345]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; protein kinase binding [GO:0019901]; voltage-gated calcium channel activity [GO:0005245]; calcium-mediated signaling [GO:0019722]; endocytosis involved in viral entry into host cell [GO:0075509]; endosome to lysosome transport of low-density lipoprotein particle [GO:0090117]; intracellular calcium ion homeostasis [GO:0006874]; intracellular pH reduction [GO:0051452]; lysosome organization [GO:0007040]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of developmental pigmentation [GO:0048086]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of autophagy [GO:0010506]; regulation of exocytosis [GO:0017157]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to vitamin D [GO:0033280]; smooth muscle contraction [GO:0006939]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:32167471}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:20880839, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:31825310, ECO:0000269|PubMed:32167471}; Multi-pass membrane protein {ECO:0000255}. Melanosome membrane {ECO:0000269|PubMed:27140606}; Multi-pass membrane protein {ECO:0000255}.
Q8NHY0	reviewed	B4GN2_HUMAN	Beta-1,4 N-acetylgalactosaminyltransferase 2 (EC 2.4.1.-) (Sd(a) beta-1,4-GalNAc transferase) (UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase)	B4GALNT2 GALGT2	Homo sapiens (Human)	566	FUNCTION: Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain. {ECO:0000269|PubMed:12678917, ECO:0000269|PubMed:14688233}.		lipid glycosylation [GO:0030259]; negative regulation of cell-cell adhesion [GO:0022408]; oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation via asparagine [GO:0018279]; UDP-N-acetylgalactosamine metabolic process [GO:0019276]; UDP-N-acetylglucosamine metabolic process [GO:0006047]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	acetylgalactosaminyltransferase activity [GO:0008376]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; acetylgalactosaminyltransferase activity [GO:0008376]; lipid glycosylation [GO:0030259]; negative regulation of cell-cell adhesion [GO:0022408]; oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation via asparagine [GO:0018279]; UDP-N-acetylgalactosamine metabolic process [GO:0019276]; UDP-N-acetylglucosamine metabolic process [GO:0006047]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8NHY2	reviewed	COP1_HUMAN	E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)	COP1 RFWD2 RNF200	Homo sapiens (Human)	731	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable). {ECO:0000269|PubMed:12466024, ECO:0000269|PubMed:12615916, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15103385, ECO:0000269|PubMed:19805145, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21625211, ECO:0000303|PubMed:27041596}.	MISCELLANEOUS: [Isoform 4]: Unable to associate with other components of the CRL complex. Acts as a dominant-negative. {ECO:0000305}.	positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212]	Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus speckle. Cytoplasm. Note=In the nucleus, it forms nuclear speckles.
Q8NHY3	reviewed	GA2L2_HUMAN	GAS2-like protein 2 (GAS2-related protein on chromosome 17) (Growth arrest-specific protein 2-like 2)	GAS2L2 GAR17	Homo sapiens (Human)	880	FUNCTION: Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704). {ECO:0000250|UniProtKB:Q5SSG4, ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950, ECO:0000269|PubMed:30665704}.		actin crosslink formation [GO:0051764]; microtubule bundle formation [GO:0001578]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; protein localization to microtubule plus-end [GO:1904825]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of microtubule polymerization or depolymerization [GO:0031110]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; G-protein alpha-subunit binding [GO:0001965]; microtubule binding [GO:0008017]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; G-protein alpha-subunit binding [GO:0001965]; microtubule binding [GO:0008017]; actin crosslink formation [GO:0051764]; microtubule bundle formation [GO:0001578]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; protein localization to microtubule plus-end [GO:1904825]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of microtubule polymerization or depolymerization [GO:0031110]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:30665704}. Cell membrane {ECO:0000250|UniProtKB:Q5SSG4}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:24706950, ECO:0000269|PubMed:30665704}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:30665704}. Note=Colocalizes with ADORA2A at neuronal processes (By similarity). Colocalizes with and tracks the tips of microtubule plus ends (PubMed:24706950). {ECO:0000250|UniProtKB:D3ZUE1, ECO:0000269|PubMed:24706950}.
Q8NHZ7	reviewed	MB3L2_HUMAN	Methyl-CpG-binding domain protein 3-like 2 (MBD3-like protein 2)	MBD3L2	Homo sapiens (Human)	208	FUNCTION: May displace the NuRD complex from chromatin. {ECO:0000269|PubMed:15701600}.	MISCELLANEOUS: The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.	DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of chromatin organization [GO:1902275]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	methyl-CpG binding [GO:0008327]	nucleus [GO:0005634]; methyl-CpG binding [GO:0008327]; DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of chromatin organization [GO:1902275]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15701600}.
Q8NHZ8	reviewed	CDC26_HUMAN	Anaphase-promoting complex subunit CDC26 (Anaphase-promoting complex subunit 12) (APC12) (Cell division cycle protein 26 homolog)	CDC26 ANAPC12 C9orf17	Homo sapiens (Human)	85	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269|PubMed:18485873}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]		anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8NI08	reviewed	NCOA7_HUMAN	Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1)	NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993	Homo sapiens (Human)	942	FUNCTION: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}.		negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to oxidative stress [GO:0006979]	nucleus [GO:0005634]	nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]	nucleus [GO:0005634]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NI17	reviewed	IL31R_HUMAN	Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)	IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384	Homo sapiens (Human)	732	FUNCTION: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity). {ECO:0000250|UniProtKB:Q8K5B1, ECO:0000269|PubMed:11877449, ECO:0000269|PubMed:14504285, ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:15194700, ECO:0000269|PubMed:15627637}.	MISCELLANEOUS: [Isoform 9]: Major isoform. Dominant negative IL31 receptor. {ECO:0000305}.; MISCELLANEOUS: [Isoform 12]: Major isoform. Functional IL31 receptor. {ECO:0000305}.	acute inflammatory response to antigenic stimulus [GO:0002438]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; defense response to other organism [GO:0098542]; glandular epithelial cell differentiation [GO:0002067]; homeostatic process [GO:0042592]; macrophage differentiation [GO:0030225]; MAPK cascade [GO:0000165]; monocyte differentiation [GO:0030224]; negative regulation of apoptotic process [GO:0043066]; negative regulation of macrophage activation [GO:0043031]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via JAK-STAT [GO:0007259]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	axon [GO:0030424]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]	axon [GO:0030424]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; acute inflammatory response to antigenic stimulus [GO:0002438]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; defense response to other organism [GO:0098542]; glandular epithelial cell differentiation [GO:0002067]; homeostatic process [GO:0042592]; macrophage differentiation [GO:0030225]; MAPK cascade [GO:0000165]; monocyte differentiation [GO:0030224]; negative regulation of apoptotic process [GO:0043066]; negative regulation of macrophage activation [GO:0043031]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via JAK-STAT [GO:0007259]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:11877449, ECO:0000305|PubMed:14504285}; Single-pass type I membrane protein {ECO:0000305|PubMed:11877449, ECO:0000305|PubMed:14504285}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q8K5B1}. Cell projection, axon {ECO:0000250|UniProtKB:Q8K5B1}.
Q8NI22	reviewed	MCFD2_HUMAN	Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein)	MCFD2 SDNSF	Homo sapiens (Human)	146	FUNCTION: The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors. {ECO:0000269|PubMed:12717434}.		protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]	calcium ion binding [GO:0005509]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; calcium ion binding [GO:0005509]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:12717434}. Endoplasmic reticulum {ECO:0000269|PubMed:12717434}. Golgi apparatus {ECO:0000269|PubMed:12717434}.
Q8NI27	reviewed	THOC2_HUMAN	THO complex subunit 2 (Tho2) (hTREX120)	THOC2 CXorf3	Homo sapiens (Human)	1593	FUNCTION: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:26166480}.		generation of neurons [GO:0048699]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; neuron development [GO:0048666]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA splicing [GO:0008380]; viral mRNA export from host cell nucleus [GO:0046784]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]	mRNA binding [GO:0003729]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]; mRNA binding [GO:0003729]; generation of neurons [GO:0048699]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; neuron development [GO:0048666]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA splicing [GO:0008380]; viral mRNA export from host cell nucleus [GO:0046784]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Nucleus speckle {ECO:0000305}.
Q8NI35	reviewed	INADL_HUMAN	InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions)	PATJ CIPP INADL	Homo sapiens (Human)	1801	FUNCTION: Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}.		establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; microtubule organizing center organization [GO:0031023]; regulation of microtubule cytoskeleton organization [GO:0070507]; tight junction assembly [GO:0120192]	apical junction complex [GO:0043296]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]		apical junction complex [GO:0043296]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; microtubule organizing center organization [GO:0031023]; regulation of microtubule cytoskeleton organization [GO:0070507]; tight junction assembly [GO:0120192]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:11964389, ECO:0000269|PubMed:12021270, ECO:0000269|PubMed:19755384, ECO:0000269|PubMed:22006950}. Apical cell membrane {ECO:0000269|PubMed:11964389}; Peripheral membrane protein {ECO:0000269|PubMed:11964389}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18596123}. Note=Localizes to the apical region at the start of epithelial cell polarization then locates to tight junctions as polarization is completed (PubMed:11964389). Localized in the paranodal region of myelinating Schwann cells (By similarity). Localized to the leading edge of the actin cortex of migrating epithelia cells (By similarity). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7}.
Q8NI36	reviewed	WDR36_HUMAN	WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP)	WDR36	Homo sapiens (Human)	951	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in the nucleolar processing of SSU 18S rRNA (PubMed:34516797, PubMed:21051332). Involved in T-cell activation and highly coregulated with IL2 (PubMed:15177553). {ECO:0000269|PubMed:15177553, ECO:0000269|PubMed:21051332, ECO:0000269|PubMed:34516797}.	MISCELLANEOUS: Depletion of WDR36 mRNA in cultured cells causes apoptotic cell death and consistently associates with a reduced 21S rRNA and delay of 18S rRNA maturation. {ECO:0000305|PubMed:21051332}.	response to stimulus [GO:0050896]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; visual perception [GO:0007601]	nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; response to stimulus [GO:0050896]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21051332, ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:34516797}.
Q8NI37	reviewed	PPTC7_HUMAN	Protein phosphatase PTC7 homolog (EC 3.1.3.16) (T-cell activation protein phosphatase 2C) (TA-PP2C) (T-cell activation protein phosphatase 2C-like)	PPTC7 TAPP2C	Homo sapiens (Human)	304	FUNCTION: Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (PubMed:30267671). Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (PubMed:30267671). {ECO:0000269|PubMed:30267671}.		peptidyl-serine dephosphorylation [GO:0070262]; regulation of ubiquinone biosynthetic process [GO:0010795]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; peptidyl-serine dephosphorylation [GO:0070262]; regulation of ubiquinone biosynthetic process [GO:0010795]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:30267671}.
Q8NI38	reviewed	IKBD_HUMAN	NF-kappa-B inhibitor delta (NFKB inhibitor delta) (I-kappa-B-delta) (IkB-delta) (IkappaBdelta) (IkappaBNS) (T-cell activation NFKB-like protein) (TA-NFKBH)	NFKBID IKBNS	Homo sapiens (Human)	313	FUNCTION: Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes. {ECO:0000250|UniProtKB:Q2TB02}.		inflammatory response [GO:0006954]; positive regulation of T-helper 17 cell differentiation [GO:2000321]; regulation of gene expression [GO:0010468]; T cell receptor signaling pathway [GO:0050852]	nucleus [GO:0005634]		nucleus [GO:0005634]; inflammatory response [GO:0006954]; positive regulation of T-helper 17 cell differentiation [GO:2000321]; regulation of gene expression [GO:0010468]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2TB02}.
Q8NI51	reviewed	CTCFL_HUMAN	Transcriptional repressor CTCFL (Brother of the regulator of imprinted sites) (CCCTC-binding factor) (CTCF paralog) (CTCF-like protein) (Cancer/testis antigen 27) (CT27) (Zinc finger protein CTCF-T)	CTCFL BORIS	Homo sapiens (Human)	663	FUNCTION: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. {ECO:0000250, ECO:0000269|PubMed:12011441, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18765639}.		cell cycle [GO:0007049]; establishment of protein localization to chromatin [GO:0071169]; genomic imprinting [GO:0071514]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin insulator sequence binding [GO:0043035]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]	chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin insulator sequence binding [GO:0043035]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; cell cycle [GO:0007049]; establishment of protein localization to chromatin [GO:0071169]; genomic imprinting [GO:0071514]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q8NI60	reviewed	COQ8A_HUMAN	Atypical kinase COQ8A, mitochondrial (EC 2.7.-.-) (Chaperone activity of bc1 complex-like) (Chaperone-ABC1-like) (Coenzyme Q protein 8A) (aarF domain-containing protein kinase 3)	COQ8A ADCK3 CABC1 PP265	Homo sapiens (Human)	647	FUNCTION: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144). {ECO:0000269|PubMed:25498144, ECO:0000269|PubMed:27499294, ECO:0000305|PubMed:21296186, ECO:0000305|PubMed:25540914}.		phosphorylation [GO:0016310]; ubiquinone biosynthetic process [GO:0006744]	membrane [GO:0016020]; mitochondrion [GO:0005739]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; kinase activity [GO:0016301]	membrane [GO:0016020]; mitochondrion [GO:0005739]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; phosphorylation [GO:0016310]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11888884, ECO:0000269|PubMed:25498144}. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255, ECO:0000305|PubMed:25216398}.
Q8NI77	reviewed	KI18A_HUMAN	Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A)	KIF18A OK/SW-cl.108	Homo sapiens (Human)	898	FUNCTION: Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}.		cellular response to estradiol stimulus [GO:0071392]; male meiotic nuclear division [GO:0007140]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; protein transport [GO:0015031]; regulation of microtubule cytoskeleton organization [GO:0070507]; seminiferous tubule development [GO:0072520]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle midzone [GO:1990023]; nucleus [GO:0005634]; ruffle [GO:0001726]	actin binding [GO:0003779]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; plus-end-directed microtubule motor activity [GO:0008574]; tubulin-dependent ATPase activity [GO:0070463]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle midzone [GO:1990023]; nucleus [GO:0005634]; ruffle [GO:0001726]; actin binding [GO:0003779]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; plus-end-directed microtubule motor activity [GO:0008574]; tubulin-dependent ATPase activity [GO:0070463]; cellular response to estradiol stimulus [GO:0071392]; male meiotic nuclear division [GO:0007140]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; protein transport [GO:0015031]; regulation of microtubule cytoskeleton organization [GO:0070507]; seminiferous tubule development [GO:0072520]	SUBCELLULAR LOCATION: Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Q8TA86	reviewed	RP9_HUMAN	Retinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1)	RP9	Homo sapiens (Human)	221	FUNCTION: Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity). {ECO:0000250}.		cognition [GO:0050890]; RNA splicing [GO:0008380]	nucleus [GO:0005634]; signal recognition particle receptor complex [GO:0005785]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	nucleus [GO:0005634]; signal recognition particle receptor complex [GO:0005785]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; cognition [GO:0050890]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8TAA9	reviewed	VANG1_HUMAN	Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)	VANGL1 STB2	Homo sapiens (Human)	524			pigmentation [GO:0043473]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]		lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; pigmentation [GO:0043473]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q8TAB3	reviewed	PCD19_HUMAN	Protocadherin-19	PCDH19 KIAA1313	Homo sapiens (Human)	1148	FUNCTION: Calcium-dependent cell-adhesion protein. {ECO:0000250|UniProtKB:F8W3X3}.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:F8W3X3}; Single-pass type I membrane protein {ECO:0000255}.
Q8TAB5	reviewed	CA216_HUMAN	UPF0500 protein C1orf216	C1orf216	Homo sapiens (Human)	229							
Q8TAC2	reviewed	JOS2_HUMAN	Josephin-2 (EC 3.4.19.12) (Josephin domain-containing protein 2)	JOSD2 SBBI54	Homo sapiens (Human)	188	FUNCTION: Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme. {ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:21118805, ECO:0000269|PubMed:23625928}.		protein deubiquitination [GO:0016579]	cytosol [GO:0005829]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; cysteine-type deubiquitinase activity [GO:0004843]; protein deubiquitination [GO:0016579]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23625928}.
Q8TAC9	reviewed	SCAM5_HUMAN	Secretory carrier-associated membrane protein 5 (Secretory carrier membrane protein 5) (hSCAMP5)	SCAMP5	Homo sapiens (Human)	235	FUNCTION: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway. {ECO:0000269|PubMed:19234194}.		exocytosis [GO:0006887]; negative regulation of endocytosis [GO:0045806]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of cytokine production [GO:0001819]; protein transport [GO:0015031]; response to endoplasmic reticulum stress [GO:0034976]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network membrane [GO:0032588]	protein-containing complex binding [GO:0044877]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network membrane [GO:0032588]; protein-containing complex binding [GO:0044877]; exocytosis [GO:0006887]; negative regulation of endocytosis [GO:0045806]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of cytokine production [GO:0001819]; protein transport [GO:0015031]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity). {ECO:0000250}.
Q8TAD2	reviewed	IL17D_HUMAN	Interleukin-17D (IL-17D) (Interleukin-27) (IL-27)	IL17D UNQ3096/PRO21175	Homo sapiens (Human)	202	FUNCTION: Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells. {ECO:0000269|PubMed:12097364}.		inflammatory response [GO:0006954]; negative regulation of hemopoiesis [GO:1903707]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; inflammatory response [GO:0006954]; negative regulation of hemopoiesis [GO:1903707]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]	SUBCELLULAR LOCATION: Secreted.
Q8TAD4	reviewed	ZNT5_HUMAN	Proton-coupled zinc antiporter SLC30A5 (Solute carrier family 30 member 5) (Zinc transporter 5) (ZnT-5) (ZnT-like transporter 1) (hZTL1)	SLC30A5 ZNT5 ZNTL1 ZTL1 UNQ863/PRO1879	Homo sapiens (Human)	765	FUNCTION: Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:11904301, PubMed:15525635, PubMed:15994300, PubMed:19366695, PubMed:22529353). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15525635, PubMed:15994300, PubMed:16636052, PubMed:35525268). Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin (PubMed:11904301). {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:15525635, ECO:0000269|PubMed:15994300, ECO:0000269|PubMed:16636052, ECO:0000269|PubMed:19366695, ECO:0000269|PubMed:22529353, ECO:0000269|PubMed:35525268}.; FUNCTION: [Isoform 2]: Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane. {ECO:0000269|PubMed:11937503, ECO:0000269|PubMed:17355957}.		cobalt ion transport [GO:0006824]; GPI anchor biosynthetic process [GO:0006506]; insulin processing [GO:0030070]; intracellular zinc ion homeostasis [GO:0006882]; response to zinc ion [GO:0010043]; zinc ion import across plasma membrane [GO:0071578]; zinc ion import into Golgi lumen [GO:1904257]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi cis cisterna membrane [GO:1990674]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; trans-Golgi network membrane [GO:0032588]	antiporter activity [GO:0015297]; metal ion binding [GO:0046872]; zinc efflux transmembrane transporter activity [GO:0022883]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi cis cisterna membrane [GO:1990674]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; trans-Golgi network membrane [GO:0032588]; antiporter activity [GO:0015297]; metal ion binding [GO:0046872]; zinc efflux transmembrane transporter activity [GO:0022883]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826]; cobalt ion transport [GO:0006824]; GPI anchor biosynthetic process [GO:0006506]; insulin processing [GO:0030070]; intracellular zinc ion homeostasis [GO:0006882]; response to zinc ion [GO:0010043]; zinc ion import across plasma membrane [GO:0071578]; zinc ion import into Golgi lumen [GO:1904257]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:12095919, ECO:0000269|PubMed:15525635, ECO:0000269|PubMed:21887337, ECO:0000269|PubMed:22529353}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:15525635}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:11904301}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19366695}; Multi-pass membrane protein {ECO:0000255}. Note=Enriched in early compartments of the secretory pathway including COPII-coated vesicles and the Golgi cis cisterna. {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:15525635}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21887337}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:11937503, ECO:0000269|PubMed:17355957}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:11937503}; Multi-pass membrane protein {ECO:0000255}.
Q8TAD8	reviewed	SNIP1_HUMAN	Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1)	SNIP1	Homo sapiens (Human)	396	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}.		canonical NF-kappaB signal transduction [GO:0007249]; miRNA processing [GO:0035196]; mRNA splicing, via spliceosome [GO:0000398]; regulation of transcription by RNA polymerase II [GO:0006357]; U2-type prespliceosome assembly [GO:1903241]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; canonical NF-kappaB signal transduction [GO:0007249]; miRNA processing [GO:0035196]; mRNA splicing, via spliceosome [GO:0000398]; regulation of transcription by RNA polymerase II [GO:0006357]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10887155, ECO:0000269|PubMed:29360106}.
Q8TAE7	reviewed	KCNG3_HUMAN	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv10.1) (Voltage-gated potassium channel subunit Kv6.3)	KCNG3	Homo sapiens (Human)	436	FUNCTION: Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135). {ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:19074135}.		potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:19074135}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12060745}. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:12060745). Colocalizes with KCNB1 at the plasma membrane (PubMed:12060745, PubMed:19074135). Remains intracellular in the absence of KCNB1 (PubMed:12060745). {ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:19074135}.
Q8TAE8	reviewed	G45IP_HUMAN	Large ribosomal subunit protein mL64 (39S ribosomal protein L59, mitochondrial) (MRP-L59) (CKII beta-associating protein) (CR6-interacting factor 1) (CRIF1) (Growth arrest and DNA damage-inducible proteins-interacting protein 1) (Papillomavirus L2-interacting nuclear protein 1) (PLINP) (PLINP-1) (p53-responsive gene 6 protein)	GADD45GIP1 MRPL59 PLINP1 PRG6	Homo sapiens (Human)	222	FUNCTION: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.	MISCELLANEOUS: Cells overexpressing GADD45GIP1 were more likely to be in G1 and less likely to be in S phase and grow more slowly than control cells. Inhibiting the expression of GADD45GIP1 promotes cell cycle progression.	cell cycle [GO:0007049]; mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]		mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; cell cycle [GO:0007049]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22453275, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}. Nucleus {ECO:0000269|PubMed:12482659}. Note=Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275). {ECO:0000269|PubMed:12482659, ECO:0000269|PubMed:22453275}.
Q8TAF3	reviewed	WDR48_HUMAN	WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80)	WDR48 KIAA1449 UAF1	Homo sapiens (Human)	677	FUNCTION: Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:31253762, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27650958, PubMed:27373336). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27650958, PubMed:27373336). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27463890, PubMed:27239033, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:20147293). Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress (PubMed:31844045). {ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:24145035, ECO:0000269|PubMed:26388029, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:27650958, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31844045, ECO:0000269|PubMed:32350107}.; FUNCTION: (Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488). {ECO:0000269|PubMed:12196293, ECO:0000269|PubMed:18032488}.	MISCELLANEOUS: Knockdown of WDR48 increases Akt activation. {ECO:0000269|PubMed:24145035}.	DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; embryonic organ development [GO:0048568]; homeostasis of number of cells [GO:0048872]; multicellular organism growth [GO:0035264]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of protein monoubiquitination [GO:1902525]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	deubiquitinase activator activity [GO:0035800]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; deubiquitinase activator activity [GO:0035800]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; embryonic organ development [GO:0048568]; homeostasis of number of cells [GO:0048872]; multicellular organism growth [GO:0035264]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of protein monoubiquitination [GO:1902525]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18032488}. Cytoplasm {ECO:0000269|PubMed:12196293, ECO:0000269|PubMed:18032488}. Lysosome {ECO:0000269|PubMed:12196293}. Late endosome {ECO:0000269|PubMed:12196293}. Note=Mainly in cytoplasmic compartments (PubMed:12196293, PubMed:18032488). In case of infection by papillomavirus HPV11, translocates to the nucleus via its interaction with papillomavirus HPV11 (PubMed:18032488). {ECO:0000269|PubMed:12196293, ECO:0000269|PubMed:18032488}.
Q8TAF8	reviewed	LHPL5_HUMAN	LHFPL tetraspan subfamily member 5 protein (Lipoma HMGIC fusion partner-like 5 protein) (Tetraspan membrane protein of hair cell stereocilia)	LHFPL5 TMHS	Homo sapiens (Human)	219	FUNCTION: In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity). {ECO:0000250}.		auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transport [GO:0006811]; sensory perception of sound [GO:0007605]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; stereocilium tip [GO:0032426]		apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; stereocilium tip [GO:0032426]; auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transport [GO:0006811]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q4KL25}; Multi-pass membrane protein {ECO:0000255}. Note=Efficient localization to the plasma membrane requires the presence of PCDH15. {ECO:0000250|UniProtKB:Q4KL25}.
Q8TAG5	reviewed	VTM2A_HUMAN	V-set and transmembrane domain-containing protein 2A	VSTM2A VSTM2	Homo sapiens (Human)	236	FUNCTION: Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway. {ECO:0000269|PubMed:28052263}.		cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of white fat cell proliferation [GO:0070352]	extracellular region [GO:0005576]	identical protein binding [GO:0042802]	extracellular region [GO:0005576]; identical protein binding [GO:0042802]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of white fat cell proliferation [GO:0070352]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8R0A6}. Note=Secreted by adipose precursor cells (By similarity). Not detected in the nucleus (PubMed:28052263). {ECO:0000250|UniProtKB:Q8R0A6}.
Q8TAG9	reviewed	EXOC6_HUMAN	Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1)	EXOC6 SEC15A SEC15L SEC15L1	Homo sapiens (Human)	804	FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). {ECO:0000250}.		exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54923}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54923}. Cell projection, growth cone {ECO:0000250|UniProtKB:O54923}. Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Note=Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation. Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). {ECO:0000250|UniProtKB:O54923, ECO:0000269|PubMed:16213214}.
Q8TAI7	reviewed	REBL1_HUMAN	GTPase RhebL1 (Ras homolog enriched in brain like-1 c) (RhebL1c) (Ras homolog enriched in brain-like protein 1) (Rheb-like protein 1) (Rheb2)	RHEBL1	Homo sapiens (Human)	183	FUNCTION: Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2. {ECO:0000269|PubMed:12869548, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:16328882, ECO:0000269|PubMed:17162089}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	positive regulation of NF-kappaB transcription factor activity [GO:0051092]; small GTPase mediated signal transduction [GO:0007264]; TOR signaling [GO:0031929]	cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; small GTPase mediated signal transduction [GO:0007264]; TOR signaling [GO:0031929]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305|PubMed:16328882}; Lipid-anchor {ECO:0000305|PubMed:16006564}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16328882}.
Q8TAK6	reviewed	OLIG1_HUMAN	Oligodendrocyte transcription factor 1 (Oligo1) (Class B basic helix-loop-helix protein 6) (bHLHb6) (Class E basic helix-loop-helix protein 21) (bHLHe21)	OLIG1 BHLHB6 BHLHE21	Homo sapiens (Human)	271	FUNCTION: Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity). {ECO:0000250, ECO:0000269|PubMed:10719889}.		axon development [GO:0061564]; neuron fate commitment [GO:0048663]; oligodendrocyte development [GO:0014003]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; axon development [GO:0061564]; neuron fate commitment [GO:0048663]; oligodendrocyte development [GO:0014003]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q8TAM1	reviewed	BBS10_HUMAN	Bardet-Biedl syndrome 10 protein	BBS10 C12orf58	Homo sapiens (Human)	723	FUNCTION: Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (PubMed:20080638). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). Involved in adipogenic differentiation (PubMed:19190184). {ECO:0000269|PubMed:19190184, ECO:0000269|PubMed:20080638}.	MISCELLANEOUS: Adipocytes derived from BBS-patients' dermal fibroblasts in culture exhibit higher propensity for fat accumulation when compared to controls. This strongly suggests that a peripheral primary dysfunction of adipogenesis participates in the pathogenesis of obesity in BBS.	chaperone-mediated protein complex assembly [GO:0051131]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; regulation of protein-containing complex assembly [GO:0043254]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	cilium [GO:0005929]	ATP binding [GO:0005524]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cilium [GO:0005929]; ATP binding [GO:0005524]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; chaperone-mediated protein complex assembly [GO:0051131]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; regulation of protein-containing complex assembly [GO:0043254]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:19190184}. Note=Located within the basal body of the primary cilium of differentiating preadipocytes. {ECO:0000269|PubMed:19190184}.
Q8TAM2	reviewed	TTC8_HUMAN	Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein)	TTC8 BBS8	Homo sapiens (Human)	541	FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	axon guidance [GO:0007411]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cilium assembly [GO:0060271]; establishment of anatomical structure orientation [GO:0048560]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; fat cell differentiation [GO:0045444]; inner ear receptor cell stereocilium organization [GO:0060122]; multi-ciliated epithelial cell differentiation [GO:1903251]; multicellular organism growth [GO:0035264]; non-motile cilium assembly [GO:1905515]; olfactory bulb development [GO:0021772]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880]; regulation of stress fiber assembly [GO:0051492]; renal tubule development [GO:0061326]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893]	BBSome [GO:0034464]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391]	RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	BBSome [GO:0034464]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; axon guidance [GO:0007411]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cilium assembly [GO:0060271]; establishment of anatomical structure orientation [GO:0048560]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; fat cell differentiation [GO:0045444]; inner ear receptor cell stereocilium organization [GO:0060122]; multi-ciliated epithelial cell differentiation [GO:1903251]; multicellular organism growth [GO:0035264]; non-motile cilium assembly [GO:1905515]; olfactory bulb development [GO:0021772]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880]; regulation of stress fiber assembly [GO:0051492]; renal tubule development [GO:0061326]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17574030}. Cell projection, cilium membrane {ECO:0000269|PubMed:17574030}. Cytoplasm {ECO:0000269|PubMed:22072986}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:17574030}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8VD72}.
Q8TAM6	reviewed	ERMIN_HUMAN	Ermin (Juxtanodin) (JN)	ERMN KIAA1189	Homo sapiens (Human)	284	FUNCTION: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; morphogenesis of a branching structure [GO:0001763]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; glial cell projection [GO:0097386]; internode region of axon [GO:0033269]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; paranode region of axon [GO:0033270]	actin filament binding [GO:0051015]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; glial cell projection [GO:0097386]; internode region of axon [GO:0033269]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; paranode region of axon [GO:0033270]; actin filament binding [GO:0051015]; actin filament organization [GO:0007015]; morphogenesis of a branching structure [GO:0001763]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q8TAP4	reviewed	LMO3_HUMAN	LIM domain only protein 3 (LMO-3) (Neuronal-specific transcription factor DAT1) (Rhombotin-3)	LMO3 RBTN3 RBTNL2 RHOM3	Homo sapiens (Human)	145			negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucocorticoid receptor signaling pathway [GO:2000324]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucocorticoid receptor signaling pathway [GO:2000324]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]	
Q8TAP6	reviewed	CEP76_HUMAN	Centrosomal protein of 76 kDa (Cep76)	CEP76 C18orf9	Homo sapiens (Human)	659	FUNCTION: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. {ECO:0000269|PubMed:19460342}.		regulation of centriole replication [GO:0046599]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]		centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; regulation of centriole replication [GO:0046599]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Does not localize along the ciliary axoneme.
Q8TAP8	reviewed	PPR35_HUMAN	Protein phosphatase 1 regulatory subunit 35	PPP1R35 C7orf47	Homo sapiens (Human)	253	FUNCTION: During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion (PubMed:30168418, PubMed:30230954). In addition, may play a role in the primary cilia assembly (By similarity). {ECO:0000250|UniProtKB:Q9D8C8, ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}.		notochord morphogenesis [GO:0048570]; positive regulation of centriole elongation [GO:1903724]; positive regulation of cilium assembly [GO:0045724]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]	phosphatase binding [GO:0019902]; protein phosphatase inhibitor activity [GO:0004864]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; phosphatase binding [GO:0019902]; protein phosphatase inhibitor activity [GO:0004864]; notochord morphogenesis [GO:0048570]; positive regulation of centriole elongation [GO:1903724]; positive regulation of cilium assembly [GO:0045724]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30168418}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}. Note=Recruited to the nascent daughter centriole early in the duplication cycle and localizes to the proximal centriolar lumen just above the cartwheel (PubMed:30168418, PubMed:30230954). Co-localizes with RTTN at the centriole (PubMed:30168418). {ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}.
Q8TAP9	reviewed	MPLKI_HUMAN	M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein)	MPLKIP C7orf11 TTDN1	Homo sapiens (Human)	179	FUNCTION: May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}.		cell cycle [GO:0007049]; cell division [GO:0051301]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell cycle [GO:0007049]; cell division [GO:0051301]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase.
Q8TAQ2	reviewed	SMRC2_HUMAN	SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)	SMARCC2 BAF170	Homo sapiens (Human)	1214	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.		chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	histone binding [GO:0042393]; transcription coactivator activity [GO:0003713]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; histone binding [GO:0042393]; transcription coactivator activity [GO:0003713]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q8TAS1	reviewed	UHMK1_HUMAN	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (PAM COOH-terminal interactor protein 2) (P-CIP2) (U2AF homology motif kinase 1)	UHMK1 KIS KIST	Homo sapiens (Human)	419	FUNCTION: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity). {ECO:0000250}.		neuron projection development [GO:0031175]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of translational initiation [GO:0045948]; protein autophosphorylation [GO:0046777]; regulation of cell cycle [GO:0051726]; regulation of protein export from nucleus [GO:0046825]	axon [GO:0030424]; dendrite cytoplasm [GO:0032839]; intracellular membrane-bounded organelle [GO:0043231]; neuronal ribonucleoprotein granule [GO:0071598]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935]; transferase activity [GO:0016740]	axon [GO:0030424]; dendrite cytoplasm [GO:0032839]; intracellular membrane-bounded organelle [GO:0043231]; neuronal ribonucleoprotein granule [GO:0071598]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935]; transferase activity [GO:0016740]; neuron projection development [GO:0031175]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of translational initiation [GO:0045948]; protein autophosphorylation [GO:0046777]; regulation of cell cycle [GO:0051726]; regulation of protein export from nucleus [GO:0046825]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23419774}.
Q8TAT2	reviewed	FGFP3_HUMAN	Fibroblast growth factor-binding protein 3 (FGF-BP3) (FGF-binding protein 3) (FGFBP-3)	FGFBP3 C10orf13 PSEC0101	Homo sapiens (Human)	258	FUNCTION: Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability. {ECO:0000269|PubMed:18669637}.		cell-cell signaling [GO:0007267]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of vascular permeability [GO:0043117]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]	fibroblast growth factor binding [GO:0017134]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; fibroblast growth factor binding [GO:0017134]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; cell-cell signaling [GO:0007267]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of vascular permeability [GO:0043117]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18669637}.
Q8TAT5	reviewed	NEIL3_HUMAN	Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3)	NEIL3	Homo sapiens (Human)	605	FUNCTION: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). No activity on 8-oxoG detected (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). {ECO:0000250|UniProtKB:A0A1L8HU22, ECO:0000269|PubMed:12433996, ECO:0000269|PubMed:19170771, ECO:0000269|PubMed:22569481, ECO:0000269|PubMed:23755964}.		base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; depurination [GO:0045007]; interstrand cross-link repair [GO:0036297]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	bubble DNA binding [GO:0000405]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA binding [GO:0003690]; MCM complex binding [GO:1904931]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; bubble DNA binding [GO:0000405]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA binding [GO:0003690]; MCM complex binding [GO:1904931]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270]; base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; depurination [GO:0045007]; interstrand cross-link repair [GO:0036297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12433996}. Chromosome {ECO:0000250|UniProtKB:A0A1L8HU22}. Note=Recruited to replication stress sites via interaction with ubiquitinated CMG helicase. {ECO:0000250|UniProtKB:A0A1L8HU22}.
Q8TAT6	reviewed	NPL4_HUMAN	Nuclear protein localization protein 4 homolog (Protein NPL4)	NPLOC4 KIAA1499 NPL4	Homo sapiens (Human)	608	FUNCTION: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES54, ECO:0000269|PubMed:26471729}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	Golgi organization [GO:0007030]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear outer membrane-endoplasmic reticulum membrane network [GO:0042175]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; UFD1-NPL4 complex [GO:0036501]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	ATPase binding [GO:0051117]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear outer membrane-endoplasmic reticulum membrane network [GO:0042175]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; UFD1-NPL4 complex [GO:0036501]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; ATPase binding [GO:0051117]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; Golgi organization [GO:0007030]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ES54}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9ES54}. Nucleus {ECO:0000250|UniProtKB:Q9ES54}. Note=Associated with the endoplasmic reticulum and nuclear. {ECO:0000250|UniProtKB:Q9ES54}.
Q8TAU0	reviewed	NKX23_HUMAN	Homeobox protein Nkx-2.3 (Homeobox protein NK-2 homolog C)	NKX2-3 NKX23 NKX2C	Homo sapiens (Human)	364	FUNCTION: Transcription factor. {ECO:0000250}.		CD4-positive, alpha-beta T cell differentiation [GO:0043367]; cell differentiation [GO:0030154]; gland morphogenesis [GO:0022612]; leukocyte homeostasis [GO:0001776]; leukocyte migration [GO:0050900]; lymph node development [GO:0048535]; macrophage differentiation [GO:0030225]; odontogenesis of dentin-containing tooth [GO:0042475]; Peyer's patch development [GO:0048541]; plasma cell differentiation [GO:0002317]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic digestive tract morphogenesis [GO:0048621]; regulation of epithelial cell proliferation [GO:0050678]; regulation of transcription by RNA polymerase II [GO:0006357]; spleen development [GO:0048536]; transcription by RNA polymerase II [GO:0006366]; triglyceride metabolic process [GO:0006641]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; cell differentiation [GO:0030154]; gland morphogenesis [GO:0022612]; leukocyte homeostasis [GO:0001776]; leukocyte migration [GO:0050900]; lymph node development [GO:0048535]; macrophage differentiation [GO:0030225]; odontogenesis of dentin-containing tooth [GO:0042475]; Peyer's patch development [GO:0048541]; plasma cell differentiation [GO:0002317]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic digestive tract morphogenesis [GO:0048621]; regulation of epithelial cell proliferation [GO:0050678]; regulation of transcription by RNA polymerase II [GO:0006357]; spleen development [GO:0048536]; transcription by RNA polymerase II [GO:0006366]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q8TAU3	reviewed	ZN417_HUMAN	Zinc finger protein 417	ZNF417	Homo sapiens (Human)	575	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TAV3	reviewed	CP2W1_HUMAN	Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1)	CYP2W1	Homo sapiens (Human)	490	FUNCTION: A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism (PubMed:22591743, PubMed:26936974). Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates (PubMed:26936974). Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs) (PubMed:22591743). Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids (PubMed:26936974, PubMed:22591743). May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:20805301, PubMed:16551781, PubMed:24278521). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:22591743, PubMed:26936974). {ECO:0000269|PubMed:16551781, ECO:0000269|PubMed:20805301, ECO:0000269|PubMed:22591743, ECO:0000269|PubMed:24278521, ECO:0000269|PubMed:26936974}.		aflatoxin metabolic process [GO:0046222]; organic acid metabolic process [GO:0006082]; phospholipid metabolic process [GO:0006644]; retinoic acid catabolic process [GO:0034653]; xenobiotic metabolic process [GO:0006805]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	all-trans retinal binding [GO:0005503]; all-trans-retinol binding [GO:1904768]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; all-trans retinal binding [GO:0005503]; all-trans-retinol binding [GO:1904768]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]; aflatoxin metabolic process [GO:0046222]; organic acid metabolic process [GO:0006082]; phospholipid metabolic process [GO:0006644]; retinoic acid catabolic process [GO:0034653]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:20805301}. Cell membrane {ECO:0000269|PubMed:20805301}. Microsome membrane {ECO:0000269|PubMed:20805301}. Note=About 8% are expressed on the cell surface. {ECO:0000269|PubMed:20805301}.
Q8TAX0	reviewed	OSR1_HUMAN	Protein odd-skipped-related 1	OSR1 ODD	Homo sapiens (Human)	266	FUNCTION: Transcription factor that plays a role in the regulation of embryonic heart and urogenital development. {ECO:0000250}.		cell differentiation [GO:0030154]; cell proliferation involved in kidney development [GO:0072111]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal joint development [GO:0072498]; embryonic skeletal joint morphogenesis [GO:0060272]; embryonic skeletal limb joint morphogenesis [GO:0036023]; gonad development [GO:0008406]; heart development [GO:0007507]; intermediate mesoderm development [GO:0048389]; mesangial cell development [GO:0072143]; mesonephric duct morphogenesis [GO:0072180]; mesonephros development [GO:0001823]; metanephric cap mesenchymal cell proliferation involved in metanephros development [GO:0090094]; metanephric epithelium development [GO:0072207]; metanephric glomerulus vasculature development [GO:0072239]; metanephric interstitial fibroblast development [GO:0072259]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchyme development [GO:0072075]; metanephric mesenchyme morphogenesis [GO:0072133]; metanephric nephron tubule development [GO:0072234]; metanephric smooth muscle tissue development [GO:0072208]; middle ear morphogenesis [GO:0042474]; negative regulation of apoptotic process [GO:0043066]; negative regulation of creatine transmembrane transporter activity [GO:1905408]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of nephron tubule epithelial cell differentiation [GO:0072183]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; pattern specification involved in metanephros development [GO:0072268]; positive regulation of bone mineralization [GO:0030501]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gastrulation [GO:2000543]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; posterior mesonephric tubule development [GO:0072166]; pronephros development [GO:0048793]; regulation of transcription by RNA polymerase II [GO:0006357]; renal vesicle progenitor cell differentiation [GO:0072184]; roof of mouth development [GO:0060021]; sodium ion transmembrane transport [GO:0035725]; specification of anterior mesonephric tubule identity [GO:0072168]; specification of posterior mesonephric tubule identity [GO:0072169]; stem cell differentiation [GO:0048863]; ureter urothelium development [GO:0072190]; ureteric bud development [GO:0001657]; urogenital system development [GO:0001655]	cell cortex [GO:0005938]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	cell cortex [GO:0005938]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; cell proliferation involved in kidney development [GO:0072111]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal joint development [GO:0072498]; embryonic skeletal joint morphogenesis [GO:0060272]; embryonic skeletal limb joint morphogenesis [GO:0036023]; gonad development [GO:0008406]; heart development [GO:0007507]; intermediate mesoderm development [GO:0048389]; mesangial cell development [GO:0072143]; mesonephric duct morphogenesis [GO:0072180]; mesonephros development [GO:0001823]; metanephric cap mesenchymal cell proliferation involved in metanephros development [GO:0090094]; metanephric epithelium development [GO:0072207]; metanephric glomerulus vasculature development [GO:0072239]; metanephric interstitial fibroblast development [GO:0072259]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchyme development [GO:0072075]; metanephric mesenchyme morphogenesis [GO:0072133]; metanephric nephron tubule development [GO:0072234]; metanephric smooth muscle tissue development [GO:0072208]; middle ear morphogenesis [GO:0042474]; negative regulation of apoptotic process [GO:0043066]; negative regulation of creatine transmembrane transporter activity [GO:1905408]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of nephron tubule epithelial cell differentiation [GO:0072183]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; pattern specification involved in metanephros development [GO:0072268]; positive regulation of bone mineralization [GO:0030501]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gastrulation [GO:2000543]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; posterior mesonephric tubule development [GO:0072166]; pronephros development [GO:0048793]; regulation of transcription by RNA polymerase II [GO:0006357]; renal vesicle progenitor cell differentiation [GO:0072184]; roof of mouth development [GO:0060021]; sodium ion transmembrane transport [GO:0035725]; specification of anterior mesonephric tubule identity [GO:0072168]; specification of posterior mesonephric tubule identity [GO:0072169]; stem cell differentiation [GO:0048863]; ureter urothelium development [GO:0072190]; ureteric bud development [GO:0001657]; urogenital system development [GO:0001655]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TAX7	reviewed	MUC7_HUMAN	Mucin-7 (MUC-7) (Apo-MG2) (Salivary mucin-7)	MUC7 MG2	Homo sapiens (Human)	377	FUNCTION: May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili. {ECO:0000269|PubMed:11378823, ECO:0000269|PubMed:8104046}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; killing of cells of another organism [GO:0031640]	extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]		extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; killing of cells of another organism [GO:0031640]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7690757}.
Q8TAX9	reviewed	GSDMB_HUMAN	Gasdermin-B (Gasdermin-like protein) [Cleaved into: Gasdermin-B, N-terminal (GSDMB-NT) (p30); Gasdermin-B, C-terminal (GSDMB-CT) (p16)]	GSDMB GSDML PP4052 PRO2521	Homo sapiens (Human)	416	FUNCTION: [Gasdermin-B]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death (PubMed:32299851). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-B, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:32299851). Also acts as a regulator of epithelial cell repair independently of programmed cell death: translocates to the plasma membrane and promotes epithelial maintenance and repair by regulating PTK2/FAK-mediated phosphorylation of PDGFA (PubMed:35021065). {ECO:0000269|PubMed:32299851, ECO:0000269|PubMed:35021065}.; FUNCTION: [Gasdermin-B, N-terminal]: Pore-forming protein produced by cleavage by granzyme A (GZMA), which causes membrane permeabilization and pyroptosis in target cells of cytotoxic T and natural killer (NK) cells (PubMed:27281216, PubMed:32299851). Key downstream mediator of granzyme-mediated cell death: (1) granzyme A (GZMA), delivered to target cells from cytotoxic T- and NK-cells, (2) specifically cleaves Gasdermin-B to generate this form (PubMed:32299851). After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:32299851, PubMed:36991122, PubMed:36991125, PubMed:36599845). The different isoforms recognize and bind different phospholipids on membranes, promoting cell death of different target cells (PubMed:34022140, PubMed:36157507, PubMed:36991122, PubMed:36991125). {ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:32299851, ECO:0000269|PubMed:34022140, ECO:0000269|PubMed:36157507, ECO:0000269|PubMed:36599845, ECO:0000269|PubMed:36991122, ECO:0000269|PubMed:36991125}.; FUNCTION: [Isoform 4]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death and mediates pyroptosis (PubMed:28154144, PubMed:36157507, PubMed:36899106, PubMed:36991122, PubMed:36991125). Following cleavage and activation by granzyme A (GZMA), the N-terminal part binds to membrane inner leaflet lipids, homooligomerizes within the human plasma membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:28154144, PubMed:36157507, PubMed:36899106, PubMed:36991122, PubMed:36991125). Recognizes and binds membrane inner leaflet lipids of human cells, such as phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, and more weakly to phosphatidic acid (PubMed:28154144, PubMed:36157507). Also binds sufatide, a component of the apical membrane of epithelial cells (PubMed:28154144). {ECO:0000269|PubMed:28154144, ECO:0000269|PubMed:36157507, ECO:0000269|PubMed:36899106, ECO:0000269|PubMed:36991122, ECO:0000269|PubMed:36991125}.; FUNCTION: [Isoform 6]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death and mediates pyroptosis of human cells (PubMed:36899106, PubMed:36991122, PubMed:36991125). Following cleavage and activation by granzyme A (GZMA), the N-terminal part binds to membrane inner leaflet lipids, homooligomerizes within the human plasma membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:36899106, PubMed:36991122, PubMed:36991125). {ECO:0000269|PubMed:36899106, ECO:0000269|PubMed:36991122, ECO:0000269|PubMed:36991125}.; FUNCTION: [Isoform 1]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death and specifically mediates cell death of Gram-negative bacteria in response to infection (PubMed:34022140). Following cleavage and activation by granzyme A (GZMA), the N-terminal part recognizes and binds phospholipids found on Gram-negative bacterial membranes, such as lipid A and cariolipin, homooligomerizes within the bacterial membranes and forms pores, triggering pyroptosis followed by cell death (PubMed:34022140). In contrast to isoform 4, does not bind to membrane inner leaflet lipids of host human cell, such as phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:34022140). {ECO:0000269|PubMed:34022140}.; FUNCTION: [Isoform 2]: Not able to trigger pyroptosis. {ECO:0000269|PubMed:36899106, ECO:0000269|PubMed:36991122, ECO:0000269|PubMed:36991125}.; FUNCTION: [Isoform 3]: Not able to trigger pyroptosis. {ECO:0000269|PubMed:36899106, ECO:0000269|PubMed:36991122, ECO:0000269|PubMed:36991125}.	MISCELLANEOUS: Long terminal repeat (LTR) of endogenous retrovirus HERV-H with reverse orientation may serve as alternative promoters of GSDMB gene. {ECO:0000269|PubMed:16625320}.; MISCELLANEOUS: [Isoform 1]: Non canonical splice junctions. {ECO:0000305|PubMed:15489334}.; MISCELLANEOUS: GSDMB may be used as predictive markers of cervical lymph node metastasis and may help, with a panel of other genes, to discriminate between primary tumors of oral squamous cell carcinoma that metastasize to cervical lymph node and those that do not metastasize. {ECO:0000269|PubMed:17391312}.	cytotoxic T cell pyroptotic process [GO:1902483]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]; pyroptosis [GO:0070269]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	cardiolipin binding [GO:1901612]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; phospholipid binding [GO:0005543]; wide pore channel activity [GO:0022829]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; cardiolipin binding [GO:1901612]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; phospholipid binding [GO:0005543]; wide pore channel activity [GO:0022829]; cytotoxic T cell pyroptotic process [GO:1902483]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]; pyroptosis [GO:0070269]	SUBCELLULAR LOCATION: [Gasdermin-B]: Cytoplasm {ECO:0000269|PubMed:18038310}. Note=Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells. {ECO:0000269|PubMed:18038310}.; SUBCELLULAR LOCATION: [Gasdermin-B, N-terminal]: Cell membrane {ECO:0000269|PubMed:36157507, ECO:0000269|PubMed:36899106}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
Q8TAZ6	reviewed	CKLF2_HUMAN	CKLF-like MARVEL transmembrane domain-containing protein 2 (Chemokine-like factor superfamily member 2)	CMTM2 CKLFSF2	Homo sapiens (Human)	248			chemotaxis [GO:0006935]	extracellular space [GO:0005615]; membrane [GO:0016020]	cytokine activity [GO:0005125]	extracellular space [GO:0005615]; membrane [GO:0016020]; cytokine activity [GO:0005125]; chemotaxis [GO:0006935]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q8TB24	reviewed	RIN3_HUMAN	Ras and Rab interactor 3 (Ras interaction/interference protein 3)	RIN3	Homo sapiens (Human)	985	FUNCTION: Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. {ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:21586568}.		endocytosis [GO:0006897]; negative regulation of mast cell chemotaxis [GO:0060755]; negative regulation of receptor internalization [GO:0002091]; regulation of vesicle size [GO:0097494]; signal transduction [GO:0007165]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; neuronal cell body [GO:0043025]; vesicle [GO:0031982]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; neuronal cell body [GO:0043025]; vesicle [GO:0031982]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; endocytosis [GO:0006897]; negative regulation of mast cell chemotaxis [GO:0060755]; negative regulation of receptor internalization [GO:0002091]; regulation of vesicle size [GO:0097494]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18486601, ECO:0000269|PubMed:21586568}. Cytoplasmic vesicle {ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:18486601, ECO:0000269|PubMed:21586568}. Early endosome {ECO:0000269|PubMed:18486601}. Note=Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles. {ECO:0000269|PubMed:18486601}.
Q8TB36	reviewed	GDAP1_HUMAN	Ganglioside-induced differentiation-associated protein 1 (GDAP1)	GDAP1	Homo sapiens (Human)	358	FUNCTION: Regulates the mitochondrial network by promoting mitochondrial fission. {ECO:0000269|PubMed:16172208}.		cellular response to vitamin D [GO:0071305]; mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; protein targeting to mitochondrion [GO:0006626]; response to retinoic acid [GO:0032526]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]		cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; cellular response to vitamin D [GO:0071305]; mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; protein targeting to mitochondrion [GO:0006626]; response to retinoic acid [GO:0032526]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:15772096, ECO:0000269|PubMed:16172208, ECO:0000269|PubMed:16857173}; Multi-pass membrane protein {ECO:0000269|PubMed:16172208}. Cytoplasm {ECO:0000250|UniProtKB:O88741}.
Q8TB37	reviewed	NUBPL_HUMAN	Iron-sulfur protein NUBPL (IND1 homolog) (Nucleotide-binding protein-like) (huInd1)	NUBPL C14orf127	Homo sapiens (Human)	319	FUNCTION: Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits. {ECO:0000269|PubMed:19752196}.	MISCELLANEOUS: [Isoform 2]: May be due to exon skipping. {ECO:0000305}.	iron-sulfur cluster assembly [GO:0016226]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrion morphogenesis [GO:0070584]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]; metal ion binding [GO:0046872]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]; metal ion binding [GO:0046872]; iron-sulfur cluster assembly [GO:0016226]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrion morphogenesis [GO:0070584]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19752196}.
Q8TB40	reviewed	ABHD4_HUMAN	(Lyso)-N-acylphosphatidylethanolamine lipase (EC 3.1.1.-) (Alpha/beta hydrolase domain-containing protein 4) (Abhydrolase domain-containing protein 4) (Alpha/beta-hydrolase 4)	ABHD4	Homo sapiens (Human)	342	FUNCTION: Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine. {ECO:0000250|UniProtKB:Q8VD66}.		lipid catabolic process [GO:0016042]; lipid homeostasis [GO:0055088]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; mitochondrion [GO:0005739]	hydrolase activity [GO:0016787]; lysophosphatidic acid acyltransferase activity [GO:0042171]; lysophospholipase activity [GO:0004622]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; mitochondrion [GO:0005739]; hydrolase activity [GO:0016787]; lysophosphatidic acid acyltransferase activity [GO:0042171]; lysophospholipase activity [GO:0004622]; lipid catabolic process [GO:0016042]; lipid homeostasis [GO:0055088]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]	
Q8TB45	reviewed	DPTOR_HUMAN	DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6)	DEPTOR DEPDC6	Homo sapiens (Human)	409	FUNCTION: Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519269, PubMed:34519268). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519269, PubMed:34519268). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:34519268, ECO:0000269|PubMed:34519269}.		intracellular signal transduction [GO:0035556]; negative regulation of cell size [GO:0045792]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of TORC2 signaling [GO:1903940]; positive regulation of autophagy [GO:0010508]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]	lysosomal membrane [GO:0005765]	phosphatidic acid binding [GO:0070300]; protein kinase inhibitor activity [GO:0004860]; protein serine/threonine kinase inhibitor activity [GO:0030291]	lysosomal membrane [GO:0005765]; phosphatidic acid binding [GO:0070300]; protein kinase inhibitor activity [GO:0004860]; protein serine/threonine kinase inhibitor activity [GO:0030291]; intracellular signal transduction [GO:0035556]; negative regulation of cell size [GO:0045792]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of TORC2 signaling [GO:1903940]; positive regulation of autophagy [GO:0010508]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000305|PubMed:25936805}. Note=Localizes to the lysosomal membrane when associated with the mTORC1 and mTORC2 complexes. {ECO:0000305|PubMed:25936805}.
Q8TB61	reviewed	S35B2_HUMAN	Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPS transporter 1) (Putative MAPK-activating protein PM15) (Putative NF-kappa-B-activating protein 48) (Solute carrier family 35 member B2)	SLC35B2 PAPST1 PSEC0149	Homo sapiens (Human)	432	FUNCTION: Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment. {ECO:0000269|PubMed:12716889}.		3'-phosphoadenosine 5'-phosphosulfate transport [GO:0046963]; 5'-adenylyl sulfate transmembrane transport [GO:1902558]; chondroitin sulfate biosynthetic process [GO:0030206]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964]; antiporter activity [GO:0015297]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964]; antiporter activity [GO:0015297]; 3'-phosphoadenosine 5'-phosphosulfate transport [GO:0046963]; 5'-adenylyl sulfate transmembrane transport [GO:1902558]; chondroitin sulfate biosynthetic process [GO:0030206]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12716889, ECO:0000269|PubMed:35325049}; Multi-pass membrane protein {ECO:0000255}.
Q8TB68	reviewed	PRR7_HUMAN	Proline-rich protein 7 (Synaptic proline-rich membrane protein)	PRR7	Homo sapiens (Human)	274	FUNCTION: Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222). {ECO:0000250|UniProtKB:P0C6T3, ECO:0000250|UniProtKB:Q3V0I2, ECO:0000269|PubMed:21460222, ECO:0000269|PubMed:27458189}.		adaptive immune response [GO:0002250]; alpha-beta T cell differentiation [GO:0046632]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; postsynapse to nucleus signaling pathway [GO:0099527]; regulation of transcription by RNA polymerase I [GO:0006356]; T cell differentiation in thymus [GO:0033077]	cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]	long-chain fatty acid binding [GO:0036041]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; ubiquitin-like protein ligase binding [GO:0044389]	cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]; long-chain fatty acid binding [GO:0036041]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; ubiquitin-like protein ligase binding [GO:0044389]; adaptive immune response [GO:0002250]; alpha-beta T cell differentiation [GO:0046632]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; postsynapse to nucleus signaling pathway [GO:0099527]; regulation of transcription by RNA polymerase I [GO:0006356]; T cell differentiation in thymus [GO:0033077]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21460222}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P0C6T3}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P0C6T3}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21460222}. Synapse {ECO:0000269|PubMed:27458189}. Cell projection, dendrite {ECO:0000269|PubMed:27458189}. Nucleus {ECO:0000269|PubMed:27458189}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. Translocates from synapses to nuclei following NMDA receptor activity (By similarity). {ECO:0000250|UniProtKB:P0C6T3}.
Q8TB72	reviewed	PUM2_HUMAN	Pumilio homolog 2 (Pumilio-2)	PUM2 KIAA0235 PUMH2	Homo sapiens (Human)	1066	FUNCTION: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; adipose tissue development [GO:0060612]; chromosome organization [GO:0051276]; hair follicle development [GO:0001942]; miRNA processing [GO:0035196]; mitochondrion organization [GO:0007005]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of sprouting of injured axon [GO:0048687]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of chromosome segregation [GO:0051983]; regulation of intracellular mRNA localization [GO:1904580]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of mRNA stability [GO:0043488]; respiratory electron transport chain [GO:0022904]; skeletal system development [GO:0001501]; stress granule assembly [GO:0034063]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]	lncRNA binding [GO:0106222]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; pumilio-response element binding [GO:0062104]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; lncRNA binding [GO:0106222]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; pumilio-response element binding [GO:0062104]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; adipose tissue development [GO:0060612]; chromosome organization [GO:0051276]; hair follicle development [GO:0001942]; miRNA processing [GO:0035196]; mitochondrion organization [GO:0007005]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of sprouting of injured axon [GO:0048687]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of chromosome segregation [GO:0051983]; regulation of intracellular mRNA localization [GO:1904580]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of mRNA stability [GO:0043488]; respiratory electron transport chain [GO:0022904]; skeletal system development [GO:0001501]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:19168546}. Cytoplasmic granule {ECO:0000269|PubMed:25340845}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19168546}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules. Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells. {ECO:0000269|PubMed:25340845}.
Q8TB73	reviewed	NDNF_HUMAN	Protein NDNF (Neuron-derived neurotrophic factor)	NDNF C4orf31 UNQ2748/PRO6487	Homo sapiens (Human)	568	FUNCTION: Secretory protein that plays a role in various cellular processes (PubMed:20969804, PubMed:24706764, PubMed:31883645). Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:20969804, PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (PubMed:31883645). Also regulates extracellular matrix assembly and cell adhesiveness (By similarity). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764). {ECO:0000250|UniProtKB:Q8C119, ECO:0000269|PubMed:20969804, ECO:0000269|PubMed:24706764, ECO:0000269|PubMed:31883645}.		angiogenesis [GO:0001525]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to hypoxia [GO:0071456]; extracellular matrix organization [GO:0030198]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; nitric oxide mediated signal transduction [GO:0007263]; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan [GO:0019800]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron projection development [GO:0010976]; response to ischemia [GO:0002931]; vascular wound healing [GO:0061042]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; angiogenesis [GO:0001525]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to hypoxia [GO:0071456]; extracellular matrix organization [GO:0030198]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; nitric oxide mediated signal transduction [GO:0007263]; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan [GO:0019800]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron projection development [GO:0010976]; response to ischemia [GO:0002931]; vascular wound healing [GO:0061042]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20969804, ECO:0000269|PubMed:24706764, ECO:0000269|PubMed:31883645}.
Q8TB92	reviewed	HMGC2_HUMAN	3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (EC 4.1.3.4) (3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1) (HMGCL-like 1) (Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase) (er-cHL)	HMGCLL1	Homo sapiens (Human)	370	FUNCTION: Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. {ECO:0000269|PubMed:22847177, ECO:0000269|PubMed:22865860}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	ketone body biosynthetic process [GO:0046951]; leucine catabolic process [GO:0006552]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	hydroxymethylglutaryl-CoA lyase activity [GO:0004419]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; hydroxymethylglutaryl-CoA lyase activity [GO:0004419]; metal ion binding [GO:0046872]; ketone body biosynthetic process [GO:0046951]; leucine catabolic process [GO:0006552]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22847177}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22847177}; Peripheral membrane protein.
Q8TBA6	reviewed	GOGA5_HUMAN	Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein)	GOLGA5 RETII RFG5 PIG31	Homo sapiens (Human)	731	FUNCTION: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}.		Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	cis-Golgi network [GO:0005801]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133]	protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]	cis-Golgi network [GO:0005801]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:9915833}; Single-pass type IV membrane protein {ECO:0000269|PubMed:9915833}. Note=Found throughout the Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network.
Q8TBB0	reviewed	THAP6_HUMAN	THAP domain-containing protein 6	THAP6	Homo sapiens (Human)	222				microtubule cytoskeleton [GO:0015630]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	microtubule cytoskeleton [GO:0015630]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]	
Q8TBB1	reviewed	LNX1_HUMAN	E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)	LNX1 LNX PDZRN2 UNQ574/PRO1136	Homo sapiens (Human)	728	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. {ECO:0000250|UniProtKB:O70263}.; FUNCTION: Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. {ECO:0000250|UniProtKB:O70263}.		protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; ubiquitin-protein transferase activity [GO:0004842]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8TBB6	reviewed	S7A14_HUMAN	Solute carrier family 7 member 14 (Gamma-aminobutyric acid transporter SLC7A14)	SLC7A14 KIAA1613	Homo sapiens (Human)	771	FUNCTION: Imports 4-aminobutanoate (GABA) into lysosomes. May act as a GABA sensor that regulates mTORC2-dependent INS signaling and gluconeogenesis. The transport mechanism and substrate selectivity remain to be elucidated. {ECO:0000250|UniProtKB:Q8BXR1}.		amino acid transport [GO:0006865]; gamma-aminobutyric acid import [GO:0051939]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; amino acid transport [GO:0006865]; gamma-aminobutyric acid import [GO:0051939]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:22787143, ECO:0000269|PubMed:24670872}; Multi-pass membrane protein {ECO:0000255}. Note=Exhibits a punctated pattern in the cytoplasm, which partially ovelaps with lysosomes. {ECO:0000250}.
Q8TBC3	reviewed	SHKB1_HUMAN	SH3KBP1-binding protein 1 (SETA-binding protein 1)	SHKBP1 SB1 PP203	Homo sapiens (Human)	707	FUNCTION: Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250|UniProtKB:Q6P7W2}.		positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; protein homooligomerization [GO:0051260]	lysosome [GO:0005764]	identical protein binding [GO:0042802]	lysosome [GO:0005764]; identical protein binding [GO:0042802]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:16733801}.
Q8TBC4	reviewed	UBA3_HUMAN	NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)	UBA3 UBE1C	Homo sapiens (Human)	463	FUNCTION: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}.	MISCELLANEOUS: Arg-211 acts as a selectivity gate, preventing misactivation of ubiquitin by this NEDD8-specific E1 complex.	endomitotic cell cycle [GO:0007113]; post-translational protein modification [GO:0043687]; protein modification process [GO:0036211]; protein neddylation [GO:0045116]; proteolysis [GO:0006508]; regulation of cell cycle [GO:0051726]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; NEDD8 activating enzyme activity [GO:0019781]; NEDD8 transferase activity [GO:0019788]; protein heterodimerization activity [GO:0046982]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; NEDD8 activating enzyme activity [GO:0019781]; NEDD8 transferase activity [GO:0019788]; protein heterodimerization activity [GO:0046982]; endomitotic cell cycle [GO:0007113]; post-translational protein modification [GO:0043687]; protein modification process [GO:0036211]; protein neddylation [GO:0045116]; proteolysis [GO:0006508]; regulation of cell cycle [GO:0051726]	
Q8TBC5	reviewed	ZSC18_HUMAN	Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447)	ZSCAN18 ZNF447	Homo sapiens (Human)	510	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q8TBE0	reviewed	BAHD1_HUMAN	Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1)	BAHD1 KIAA0945	Homo sapiens (Human)	780	FUNCTION: Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}.		heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]	chromatin silencing complex [GO:0005677]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; transcription cis-regulatory region binding [GO:0000976]	chromatin silencing complex [GO:0005677]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; transcription cis-regulatory region binding [GO:0000976]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19666599}. Chromosome {ECO:0000269|PubMed:19666599}. Note=Localizes to heterochromatin and inactive X chromosome. Colocalizes with histone H3 trimethylated at 'Lys-27' (H3K27me3).
Q8TBE1	reviewed	CNIH3_HUMAN	Protein cornichon homolog 3 (CNIH-3) (Cornichon family AMPA receptor auxiliary protein 3)	CNIH3	Homo sapiens (Human)	160	FUNCTION: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. {ECO:0000269|PubMed:20805473}.		regulation of AMPA receptor activity [GO:2000311]; vesicle-mediated transport [GO:0016192]	AMPA glutamate receptor complex [GO:0032281]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]		AMPA glutamate receptor complex [GO:0032281]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; regulation of AMPA receptor activity [GO:2000311]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}.
Q8TBE3	reviewed	FNDC9_HUMAN	Fibronectin type III domain-containing protein 9	FNDC9 C5orf40	Homo sapiens (Human)	224				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8TBE7	reviewed	S35G2_HUMAN	Solute carrier family 35 member G2 (Transmembrane protein 22)	SLC35G2 TMEM22	Homo sapiens (Human)	412				Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]		Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19148500}; Multi-pass membrane protein {ECO:0000269|PubMed:19148500}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:34269178}; Multi-pass membrane protein {ECO:0000269|PubMed:19148500}.
Q8TBE9	reviewed	NANP_HUMAN	N-acylneuraminate-9-phosphatase (EC 3.1.3.29) (Haloacid dehalogenase-like hydrolase domain-containing protein 4) (Neu5Ac-9-Pase)	NANP C20orf147 HDHD4	Homo sapiens (Human)	248			carbohydrate metabolic process [GO:0005975]; dephosphorylation [GO:0016311]; N-acetylglucosamine biosynthetic process [GO:0006045]; N-acetylneuraminate biosynthetic process [GO:0046380]	cytosol [GO:0005829]	N-acylneuraminate-9-phosphatase activity [GO:0050124]	cytosol [GO:0005829]; N-acylneuraminate-9-phosphatase activity [GO:0050124]; carbohydrate metabolic process [GO:0005975]; dephosphorylation [GO:0016311]; N-acetylglucosamine biosynthetic process [GO:0006045]; N-acetylneuraminate biosynthetic process [GO:0046380]	
Q8TBF2	reviewed	PXL2B_HUMAN	Prostamide/prostaglandin F synthase (Prostamide/PG F synthase) (Prostamide/PGF synthase) (EC 1.11.1.20) (Peroxiredoxin-like 2B) (Protein FAM213B)	PRXL2B C1orf93 FAM213B	Homo sapiens (Human)	198	FUNCTION: Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity). {ECO:0000250|UniProtKB:Q9DB60}.		prostaglandin biosynthetic process [GO:0001516]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209]	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin-F synthase activity [GO:0047017]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin-F synthase activity [GO:0047017]; prostaglandin biosynthetic process [GO:0001516]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9DB60}.
Q8TBG4	reviewed	AT2L1_HUMAN	Ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) (Alanine--glyoxylate aminotransferase 2-like 1)	ETNPPL AGXT2L1	Homo sapiens (Human)	499	FUNCTION: Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde. {ECO:0000269|PubMed:22241472}.			mitochondrial matrix [GO:0005759]	ethanolamine-phosphate phospho-lyase activity [GO:0050459]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]	mitochondrial matrix [GO:0005759]; ethanolamine-phosphate phospho-lyase activity [GO:0050459]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q8TBG9	reviewed	SYNPR_HUMAN	Synaptoporin	SYNPR	Homo sapiens (Human)	265	FUNCTION: Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity). {ECO:0000250}.			neuron projection [GO:0043005]; synaptic vesicle membrane [GO:0030672]		neuron projection [GO:0043005]; synaptic vesicle membrane [GO:0030672]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}.
Q8TBJ4	reviewed	PLPR1_HUMAN	Phospholipid phosphatase-related protein type 1 (Inactive 2-lysophosphatidate phosphatase PLPPR1) (Lipid phosphate phosphatase-related protein type 1) (Plasticity-related gene 3 protein) (PRG-3)	PLPPR1 LPPR1 PRG3	Homo sapiens (Human)	325	FUNCTION: May play a role in neurite outgrowth and neurogenesis. {ECO:0000250|UniProtKB:Q6WAY2}.		nervous system development [GO:0007399]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165]	neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	phosphatidate phosphatase activity [GO:0008195]	neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; phosphatidate phosphatase activity [GO:0008195]; nervous system development [GO:0007399]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6WAY2}; Multi-pass membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q6WAY2}.
Q8TBJ5	reviewed	FEZF2_HUMAN	Fez family zinc finger protein 2 (Forebrain embryonic zinc finger-like protein 2) (Zinc finger protein 312) (Zinc finger protein Fez-like)	FEZF2 FEZL ZNF312 FKSG36	Homo sapiens (Human)	459	FUNCTION: Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity). {ECO:0000250}.		axonal fasciculation [GO:0007413]; cell dedifferentiation [GO:0043697]; cerebral cortex GABAergic interneuron migration [GO:0021853]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; dendrite development [GO:0016358]; dentate gyrus development [GO:0021542]; forebrain anterior/posterior pattern specification [GO:0021797]; locomotory behavior [GO:0007626]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron differentiation [GO:0045665]; neuron fate determination [GO:0048664]; positive regulation of neuron differentiation [GO:0045666]; regulation of axon guidance [GO:1902667]; regulation of gene expression [GO:0010468]; regulation of neurogenesis [GO:0050767]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; axonal fasciculation [GO:0007413]; cell dedifferentiation [GO:0043697]; cerebral cortex GABAergic interneuron migration [GO:0021853]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; dendrite development [GO:0016358]; dentate gyrus development [GO:0021542]; forebrain anterior/posterior pattern specification [GO:0021797]; locomotory behavior [GO:0007626]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron differentiation [GO:0045665]; neuron fate determination [GO:0048664]; positive regulation of neuron differentiation [GO:0045666]; regulation of axon guidance [GO:1902667]; regulation of gene expression [GO:0010468]; regulation of neurogenesis [GO:0050767]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8TBK2	reviewed	SETD6_HUMAN	N-lysine methyltransferase SETD6 (EC 2.1.1.-) (SET domain-containing protein 6)	SETD6	Homo sapiens (Human)	473	FUNCTION: Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity (PubMed:21131967, PubMed:30189201, PubMed:21515635). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity). Methylates PAK4. {ECO:0000250|UniProtKB:Q9CWY3, ECO:0000269|PubMed:21131967, ECO:0000269|PubMed:21515635, ECO:0000269|PubMed:23324626, ECO:0000269|PubMed:30189201}.		negative regulation of NF-kappaB transcription factor activity [GO:0032088]; peptidyl-lysine monomethylation [GO:0018026]; regulation of inflammatory response [GO:0050727]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	NF-kappaB binding [GO:0051059]; protein-lysine N-methyltransferase activity [GO:0016279]; S-adenosyl-L-methionine binding [GO:1904047]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NF-kappaB binding [GO:0051059]; protein-lysine N-methyltransferase activity [GO:0016279]; S-adenosyl-L-methionine binding [GO:1904047]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; peptidyl-lysine monomethylation [GO:0018026]; regulation of inflammatory response [GO:0050727]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21131967}.
Q8TBK6	reviewed	ZCH10_HUMAN	Zinc finger CCHC domain-containing protein 10	ZCCHC10	Homo sapiens (Human)	192					nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	
Q8TBM7	reviewed	TM254_HUMAN	Transmembrane protein 254	TMEM254 C10orf57	Homo sapiens (Human)	123				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8TBM8	reviewed	DJB14_HUMAN	DnaJ homolog subfamily B member 14	DNAJB14 UNQ9427/PRO34683	Homo sapiens (Human)	379	FUNCTION: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}.		cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein-containing complex assembly [GO:0065003]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]	Hsp70 protein binding [GO:0030544]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; Hsp70 protein binding [GO:0030544]; cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:24732912}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to the endoplasmic reticulum membrane (PubMed:23018488, PubMed:24732912, PubMed:27916661). When overexpressed, forms membranous structures in the nucleus (PubMed:24732912). {ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; SUBCELLULAR LOCATION: Note=(Microbial infection) Upon SV40 infection, colocalizes with BCAP31, DNAJB12 and DNAJC18 in punctate structures within the endoplasmic reticulum membrane. {ECO:0000269|PubMed:25631089}.
Q8TBN0	reviewed	R3GEF_HUMAN	Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1)	RAB3IL1	Homo sapiens (Human)	382	FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. {ECO:0000269|PubMed:20937701}.		exocytosis [GO:0006887]; protein transport [GO:0015031]	cytosol [GO:0005829]; Golgi to plasma membrane transport vesicle [GO:0070319]	guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; Golgi to plasma membrane transport vesicle [GO:0070319]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; exocytosis [GO:0006887]; protein transport [GO:0015031]	
Q8TBP5	reviewed	F174A_HUMAN	Membrane protein FAM174A (Hepatitis C virus NS5A-transactivated protein 6) (HCV NS5A-transactivated protein 6) (Transmembrane protein 157)	FAM174A NS5ATP6 TMEM157 UNQ1912/PRO4371	Homo sapiens (Human)	190				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8TBX8	reviewed	PI42C_HUMAN	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)	PIP4K2C PIP5K2C	Homo sapiens (Human)	421	FUNCTION: Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439}.		1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular organelle [GO:0043229]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular organelle [GO:0043229]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:O88370}. Cytoplasm {ECO:0000250|UniProtKB:O88370}.
Q8TBY0	reviewed	RBM46_HUMAN	Probable RNA-binding protein 46 (Cancer/testis antigen 68) (CT68) (RNA-binding motif protein 46)	RBM46	Homo sapiens (Human)	533	FUNCTION: Essential for male and female fertility, playing a crucial role in regulating germ cell development by ensuring the proper progression of meiosis prophase I (By similarity). Regulates mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2 which recognizes and down-regulates mitotic transcripts for a successful meiotic entry (By similarity). Required for normal synaptonemal complex formation during meiosis, binding meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions and positively regulating their translation (By similarity). Required for spermatogonial differentiation in both developing and adult testis (By similarity). {ECO:0000250|UniProtKB:P86049}.		cell cycle switching, mitotic to meiotic cell cycle [GO:0051728]; female meiotic nuclear division [GO:0007143]; male meiotic nuclear division [GO:0007140]; mRNA stabilization [GO:0048255]; oogenesis [GO:0048477]; spermatid differentiation [GO:0048515]; spermatogenesis [GO:0007283]; trophectodermal cell differentiation [GO:0001829]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; cell cycle switching, mitotic to meiotic cell cycle [GO:0051728]; female meiotic nuclear division [GO:0007143]; male meiotic nuclear division [GO:0007140]; mRNA stabilization [GO:0048255]; oogenesis [GO:0048477]; spermatid differentiation [GO:0048515]; spermatogenesis [GO:0007283]; trophectodermal cell differentiation [GO:0001829]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P86049}.
Q8TBY8	reviewed	PMFBP_HUMAN	Polyamine-modulated factor 1-binding protein 1 (PMF-1-binding protein)	PMFBP1	Homo sapiens (Human)	1007	FUNCTION: Required for normal spermatogenesis (PubMed:1770140, PubMed:30032984, PubMed:30298696). It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity (PubMed:30032984). May also be involved in the general organization of cellular cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q9WVQ0, ECO:0000269|PubMed:1770140, ECO:0000269|PubMed:30032984, ECO:0000269|PubMed:30298696}.		spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; sperm connecting piece [GO:0097224]		cytoplasm [GO:0005737]; sperm connecting piece [GO:0097224]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:30032984, ECO:0000269|PubMed:30298696}. Note=Localized at the sperm head-tail connecting piece (PubMed:30032984, PubMed:30298696). During spermatogenesis, it is first observed in the cytoplasm of round spermatids, it later appears in the implantation fossa region of the sperm nucleus during sperm head elongation and differentiation, and finally it localizes to the head-tail connecting piece (By similarity). {ECO:0000250|UniProtKB:Q9WVQ0, ECO:0000269|PubMed:30032984, ECO:0000269|PubMed:30298696}.
Q8TBY9	reviewed	CF251_HUMAN	Cilia- and flagella-associated protein 251 (WD repeat-containing protein 66)	CFAP251 WDR66	Homo sapiens (Human)	1149	FUNCTION: Involved in spermatozoa motility (PubMed:30122540, PubMed:30122541). May also regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity). {ECO:0000250|UniProtKB:A8IRK7, ECO:0000250|UniProtKB:Q24DE2, ECO:0000269|PubMed:30122540, ECO:0000269|PubMed:30122541}.		cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]	axoneme [GO:0005930]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]		axoneme [GO:0005930]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]; cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A8IRK7}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:30122540, ECO:0000269|PubMed:30122541}.
Q8TBZ2	reviewed	MYBPP_HUMAN	MYCBP-associated protein (AMAM-1) (AMY-1-binding protein 1) (AMAP-1)	MYCBPAP AMAP1	Homo sapiens (Human)	947	FUNCTION: May play a role in spermatogenesis. May be involved in synaptic processes (By similarity). {ECO:0000250|UniProtKB:Q69CM7, ECO:0000269|PubMed:12151104}.		cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; endocytosis [GO:0006897]; spermatogenesis [GO:0007283]	clathrin vesicle coat [GO:0030125]; cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886]; synapse [GO:0045202]	clathrin binding [GO:0030276]; phospholipid binding [GO:0005543]	clathrin vesicle coat [GO:0030125]; cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886]; synapse [GO:0045202]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543]; cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; endocytosis [GO:0006897]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12151104}. Membrane {ECO:0000250|UniProtKB:Q69CM7}. Note=Colocalizes with MYCBP in the cytoplasm. {ECO:0000250|UniProtKB:Q69CM7, ECO:0000269|PubMed:12151104}.
Q8TBZ3	reviewed	WDR20_HUMAN	WD repeat-containing protein 20 (Protein DMR)	WDR20	Homo sapiens (Human)	569	FUNCTION: Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336}.			nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	
Q8TBZ6	reviewed	TM10A_HUMAN	tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A)	TRMT10A RG9MTD2	Homo sapiens (Human)	339	FUNCTION: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). {ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:25053765}.		tRNA methylation [GO:0030488]; tRNA N1-guanine methylation [GO:0002939]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]; tRNA (guanine(9)-N(1))-methyltransferase activity [GO:0052905]; tRNA (guanine-N1-)-methyltransferase activity [GO:0009019]; tRNA binding [GO:0000049]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; tRNA (guanine(9)-N(1))-methyltransferase activity [GO:0052905]; tRNA (guanine-N1-)-methyltransferase activity [GO:0009019]; tRNA binding [GO:0000049]; tRNA methylation [GO:0030488]; tRNA N1-guanine methylation [GO:0002939]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24204302}. Nucleus, nucleolus {ECO:0000269|PubMed:24204302}.
Q8TBZ8	reviewed	ZN564_HUMAN	Zinc finger protein 564	ZNF564	Homo sapiens (Human)	553	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TC05	reviewed	MDM1_HUMAN	Nuclear protein MDM1	MDM1	Homo sapiens (Human)	714	FUNCTION: Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}.		negative regulation of centriole replication [GO:0046600]; retina development in camera-type eye [GO:0060041]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]	microtubule binding [GO:0008017]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; microtubule binding [GO:0008017]; negative regulation of centriole replication [GO:0046600]; retina development in camera-type eye [GO:0060041]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26337392}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:26337392}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26337392}. Note=Localizes to the centriole lumen. {ECO:0000269|PubMed:26337392}.
Q8TC07	reviewed	TBC15_HUMAN	TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP)	TBC1D15	Homo sapiens (Human)	691	FUNCTION: Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). {ECO:0000250}.		regulation of GTPase activity [GO:0043087]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; GTPase activator activity [GO:0005096]; regulation of GTPase activity [GO:0043087]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8TC12	reviewed	RDH11_HUMAN	Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1)	RDH11 ARSDR1 PSDR1 SDR7C1 CGI-82	Homo sapiens (Human)	318	FUNCTION: Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956). {ECO:0000269|PubMed:12036956, ECO:0000269|PubMed:12226107, ECO:0000269|PubMed:15865448, ECO:0000269|PubMed:29410696}.	MISCELLANEOUS: Shows clear specificity for the pro-S hydrogen on C4 of NADPH and the pro-R hydrogen on C15 of retinols. {ECO:0000269|PubMed:12226107}.	adaptation of rhodopsin mediated signaling [GO:0016062]; cellular detoxification of aldehyde [GO:0110095]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]	endoplasmic reticulum membrane [GO:0005789]; photoreceptor inner segment [GO:0001917]	11-cis-retinol dehydrogenase activity [GO:0102354]; aldehyde dehydrogenase (NADP+) activity [GO:0033721]; NAD-retinol dehydrogenase activity [GO:0004745]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	endoplasmic reticulum membrane [GO:0005789]; photoreceptor inner segment [GO:0001917]; 11-cis-retinol dehydrogenase activity [GO:0102354]; aldehyde dehydrogenase (NADP+) activity [GO:0033721]; NAD-retinol dehydrogenase activity [GO:0004745]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; adaptation of rhodopsin mediated signaling [GO:0016062]; cellular detoxification of aldehyde [GO:0110095]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12036956}; Single-pass type II membrane protein {ECO:0000269|PubMed:12036956}.
Q8TC20	reviewed	CAGE1_HUMAN	Cancer-associated gene 1 protein (CAGE-1) (Cancer/testis antigen 3) (CT3)	CAGE1 CTAG3	Homo sapiens (Human)	777		MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q8TC26	reviewed	TM163_HUMAN	Transmembrane protein 163	TMEM163	Homo sapiens (Human)	289	FUNCTION: Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (PubMed:25130899, PubMed:31697912, PubMed:36204728). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (PubMed:32492420). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (PubMed:35455965). {ECO:0000250|UniProtKB:A9CMA6, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:31697912, ECO:0000269|PubMed:32492420, ECO:0000269|PubMed:35455965, ECO:0000269|PubMed:36204728}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Dubious isoform that could be a cloning artifact. {ECO:0000305}.	myelination [GO:0042552]; zinc export across plasma membrane [GO:0140882]; zinc ion import into synaptic vesicle [GO:0099180]	early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	zinc ion binding [GO:0008270]	early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; zinc ion binding [GO:0008270]; myelination [GO:0042552]; zinc export across plasma membrane [GO:0140882]; zinc ion import into synaptic vesicle [GO:0099180]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8C996}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:A9CMA6}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:25130899}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:25130899}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:25130899}; Multi-pass membrane protein {ECO:0000255}. Note=Glutamatergic synaptic vesicles. {ECO:0000250|UniProtKB:A9CMA6}.
Q8TC27	reviewed	ADA32_HUMAN	Disintegrin and metalloproteinase domain-containing protein 32 (ADAM 32)	ADAM32 UNQ5982/PRO21340	Homo sapiens (Human)	787	FUNCTION: May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. {ECO:0000250}.		binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; male gonad development [GO:0008584]; proteolysis [GO:0006508]	plasma membrane [GO:0005886]	metalloendopeptidase activity [GO:0004222]	plasma membrane [GO:0005886]; metalloendopeptidase activity [GO:0004222]; binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; male gonad development [GO:0008584]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8TC29	reviewed	ENKUR_HUMAN	Enkurin	ENKUR C10orf63	Homo sapiens (Human)	256	FUNCTION: Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). {ECO:0000250|UniProtKB:Q6SP97, ECO:0000269|PubMed:36191189}.		establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]	9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; acrosomal vesicle [GO:0001669]; axonemal microtubule [GO:0005879]; sperm principal piece [GO:0097228]	calmodulin binding [GO:0005516]; SH3 domain binding [GO:0017124]	9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; acrosomal vesicle [GO:0001669]; axonemal microtubule [GO:0005879]; sperm principal piece [GO:0097228]; calmodulin binding [GO:0005516]; SH3 domain binding [GO:0017124]; establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q6SP97}. Note=Sperm acrosomal crescent and flagellar principal piece. {ECO:0000250|UniProtKB:Q6SP97}.
Q8TC36	reviewed	SUN5_HUMAN	SUN domain-containing protein 5 (Sad1 and UNC84 domain-containing protein 5) (Sperm-associated antigen 4-like protein) (Testis and spermatogenesis-related gene 4 protein)	SUN5 SPAG4L TSARG4	Homo sapiens (Human)	379	FUNCTION: Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. {ECO:0000305|PubMed:28541472, ECO:0000305|PubMed:28945193}.		spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	Golgi apparatus [GO:0005794]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; sperm connecting piece [GO:0097224]	protein-membrane adaptor activity [GO:0043495]	Golgi apparatus [GO:0005794]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; sperm connecting piece [GO:0097224]; protein-membrane adaptor activity [GO:0043495]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000305|PubMed:27640305}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9DA32}. Golgi apparatus {ECO:0000250|UniProtKB:Q9DA32}. Note=During spermiogenesis, traffics through the Golgi apparatus before reaching the round spermatid inner membrane of the nuclear envelope and later migrates to the coupling apparatus of the sperm during sperm head elongation and differentiation. In mature spermatozoa, is localized to the coupling apparatus of the sperm head and tail in the implementation fossa. {ECO:0000305|PubMed:27640305}.
Q8TC41	reviewed	RN217_HUMAN	E3 ubiquitin-protein ligase RNF217 (EC 2.3.2.31) (IBR domain-containing protein 1) (Opposite STL) (RING finger protein 217)	RNF217 C6orf172 IBRDC1 OSTL	Homo sapiens (Human)	542	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis. {ECO:0000250|UniProtKB:D3YYI7}.		positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:25298122}.
Q8TC44	reviewed	POC1B_HUMAN	POC1 centriolar protein homolog B (Pix1) (Proteome of centriole protein 1B) (WD repeat-containing protein 51B)	POC1B WDR51B	Homo sapiens (Human)	478	FUNCTION: Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567, PubMed:32060285). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation (PubMed:32060285). Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745). {ECO:0000269|PubMed:19109428, ECO:0000269|PubMed:20008567, ECO:0000269|PubMed:23015594, ECO:0000269|PubMed:25044745, ECO:0000269|PubMed:32060285}.		cell population proliferation [GO:0008283]; centriole replication [GO:0007099]; cilium assembly [GO:0060271]; retina homeostasis [GO:0001895]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; spindle pole [GO:0000922]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; spindle pole [GO:0000922]; cell population proliferation [GO:0008283]; centriole replication [GO:0007099]; cilium assembly [GO:0060271]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:19109428, ECO:0000269|PubMed:23015594, ECO:0000269|PubMed:32060285}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:20008567}. Cytoplasm, cytoskeleton, spindle pole. Note=Component of both mother and daughter centrioles (PubMed:32060285). Localizes to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in synapses of the outer plexiform layer. {ECO:0000250|UniProtKB:Q8BHD1, ECO:0000269|PubMed:32060285}.
Q8TC57	reviewed	M1AP_HUMAN	Meiosis 1 arrest protein (Meiosis 1-arresting protein) (Meiosis 1-associated protein) (Spermatogenesis-associated protein 37)	M1AP C2orf65 SPATA37	Homo sapiens (Human)	530	FUNCTION: Required for meiosis I progression during spermatogenesis. {ECO:0000269|PubMed:32673564}.		cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; female gamete generation [GO:0007292]; male meiosis chromosome separation [GO:0051308]; meiosis I [GO:0007127]; RNA processing [GO:0006396]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; membrane [GO:0016020]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; membrane [GO:0016020]; identical protein binding [GO:0042802]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; female gamete generation [GO:0007292]; male meiosis chromosome separation [GO:0051308]; meiosis I [GO:0007127]; RNA processing [GO:0006396]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8TC59	reviewed	PIWL2_HUMAN	Piwi-like protein 2 (EC 3.1.26.-) (Cancer/testis antigen 80) (CT80)	PIWIL2 HILI	Homo sapiens (Human)	973	FUNCTION: Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660). Represses circadian rhythms by promoting the stability and activity of core clock components BMAL1 and CLOCK by inhibiting GSK3B-mediated phosphorylation and ubiquitination-dependent degradation of these proteins (PubMed:28903391). {ECO:0000250|UniProtKB:Q8CDG1, ECO:0000269|PubMed:16377660, ECO:0000269|PubMed:28903391}.		germ-line stem cell population maintenance [GO:0030718]; meiotic cell cycle [GO:0051321]; negative regulation of circadian rhythm [GO:0042754]; oogenesis [GO:0048477]; piRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141006]; positive regulation of meiosis I [GO:0060903]; positive regulation of translation [GO:0045727]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposon silencing by heterochromatin formation [GO:0141005]; retrotransposon silencing by mRNA destabilization [GO:0141008]; rhythmic process [GO:0048511]; secondary piRNA processing [GO:0140965]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; dense body [GO:0097433]; nucleus [GO:0005634]; P granule [GO:0043186]; perinucleolar chromocenter [GO:0010370]; PET complex [GO:1990923]; pi-body [GO:0071546]	metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; piRNA binding [GO:0034584]; polysome binding [GO:1905538]; RNA endonuclease activity [GO:0004521]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; dense body [GO:0097433]; nucleus [GO:0005634]; P granule [GO:0043186]; perinucleolar chromocenter [GO:0010370]; PET complex [GO:1990923]; pi-body [GO:0071546]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; piRNA binding [GO:0034584]; polysome binding [GO:1905538]; RNA endonuclease activity [GO:0004521]; germ-line stem cell population maintenance [GO:0030718]; meiotic cell cycle [GO:0051321]; negative regulation of circadian rhythm [GO:0042754]; oogenesis [GO:0048477]; piRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141006]; positive regulation of meiosis I [GO:0060903]; positive regulation of translation [GO:0045727]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposon silencing by heterochromatin formation [GO:0141005]; retrotransposon silencing by mRNA destabilization [GO:0141008]; rhythmic process [GO:0048511]; secondary piRNA processing [GO:0140965]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8CDG1}. Note=Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q8CDG1}.
Q8TC71	reviewed	MIEAP_HUMAN	Mitochondria-eating protein (Spermatogenesis-associated protein 18)	SPATA18 MIEAP	Homo sapiens (Human)	538	FUNCTION: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. {ECO:0000269|PubMed:21264221, ECO:0000269|PubMed:21264228, ECO:0000269|PubMed:22292033}.		DNA damage response [GO:0006974]; mitochondrial protein catabolic process [GO:0035694]; mitophagy by induced vacuole formation [GO:0035695]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; identical protein binding [GO:0042802]; DNA damage response [GO:0006974]; mitochondrial protein catabolic process [GO:0035694]; mitophagy by induced vacuole formation [GO:0035695]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21264228, ECO:0000269|PubMed:22292033}. Mitochondrion outer membrane {ECO:0000269|PubMed:21264228, ECO:0000269|PubMed:22292033}. Note=Localizes to the cytoplasm under normal conditions (PubMed:21264228). Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane (PubMed:22292033). {ECO:0000269|PubMed:21264228, ECO:0000269|PubMed:22292033}.
Q8TC84	reviewed	FANK1_HUMAN	Fibronectin type 3 and ankyrin repeat domains protein 1	FANK1 HSD13 UNQ6504/PRO21382	Homo sapiens (Human)	345	FUNCTION: Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis. {ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:27060496}.		negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of apoptotic process [GO:0042981]	ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:27060496}. Cytoplasm, cytosol {ECO:0000269|PubMed:20978819}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9DAM9}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9DAM9}.
Q8TC92	reviewed	ENOX1_HUMAN	Ecto-NOX disulfide-thiol exchanger 1 (Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase) (cCNOX) (Cell proliferation-inducing gene 38 protein) (Constitutive Ecto-NOX) (cNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)]	ENOX1 PIG38	Homo sapiens (Human)	643	FUNCTION: Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269|PubMed:11360993, ECO:0000269|PubMed:12565167, ECO:0000269|PubMed:17027975, ECO:0000269|PubMed:19055324}.		ultradian rhythm [GO:0007624]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	NADH dehydrogenase activity [GO:0003954]; protein disulfide isomerase activity [GO:0003756]; RNA binding [GO:0003723]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; NADH dehydrogenase activity [GO:0003954]; protein disulfide isomerase activity [GO:0003756]; RNA binding [GO:0003723]; ultradian rhythm [GO:0007624]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11360993}. Secreted, extracellular space {ECO:0000269|PubMed:11360993}. Note=Extracellular and plasma membrane-associated.
Q8TC94	reviewed	ACTL9_HUMAN	Actin-like protein 9	ACTL9 ACTL7C HSD21	Homo sapiens (Human)	416	FUNCTION: Testis-specic protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation. {ECO:0000269|PubMed:33626338}.		acrosome assembly [GO:0001675]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; fertilization [GO:0009566]; single fertilization [GO:0007338]	acrosomal vesicle [GO:0001669]; actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; perinuclear theca [GO:0033011]; sperm head [GO:0061827]; synapse [GO:0045202]	protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]	acrosomal vesicle [GO:0001669]; actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; perinuclear theca [GO:0033011]; sperm head [GO:0061827]; synapse [GO:0045202]; protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; acrosome assembly [GO:0001675]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; fertilization [GO:0009566]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:33626338}. Cytoplasm, cytoskeleton, perinuclear theca {ECO:0000269|PubMed:33626338}. Note=Localizes predominantly in the equatorial segment of the sperm head and neck regions, with some localization in the acrosomal segment of the head. Colocalizes in the acrosomal and equatorial segments of sperm with ACTL7A. Colocalizes with PLCZ1 in the equatorial segment of the head of capacitated sperm. {ECO:0000269|PubMed:33626338}.
Q8TCB7	reviewed	METL6_HUMAN	tRNA N(3)-methylcytidine methyltransferase METTL6 (EC 2.1.1.-) (Methyltransferase-like protein 6) (hMETTL6)	METTL6	Homo sapiens (Human)	284	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU) (PubMed:32923617, PubMed:34922197, PubMed:34268557, PubMed:34862464). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation (PubMed:34268557). {ECO:0000269|PubMed:32923617, ECO:0000269|PubMed:34268557, ECO:0000269|PubMed:34862464, ECO:0000269|PubMed:34922197}.		tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	enzyme binding [GO:0019899]; tRNA (cytosine-3-)-methyltransferase activity [GO:0052735]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; tRNA (cytosine-3-)-methyltransferase activity [GO:0052735]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34268557}. Nucleus {ECO:0000269|PubMed:34268557}.
Q8TCC7	reviewed	S22A8_HUMAN	Organic anion transporter 3 (hOAT3) (Organic anion/dicarboxylate exchanger) (Solute carrier family 22 member 8)	SLC22A8 OAT3	Homo sapiens (Human)	542	FUNCTION: Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient (PubMed:14586168, PubMed:15644426, PubMed:15846473, PubMed:16455804, PubMed:31553721). Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (PubMed:14586168, PubMed:15846473, PubMed:15864504, PubMed:22108572, PubMed:23832370). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:14586168, PubMed:15846473, PubMed:11306713). E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange (PubMed:26377792). Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule (PubMed:11907186). Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate (PubMed:22108572, PubMed:23832370). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (PubMed:28534121). May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside (PubMed:15644426). May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (PubMed:15846473, PubMed:16455804, PubMed:11669456). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS), indole acetate (IA), hippurate/N-benzoylglycine (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (PubMed:14675047). May contribute to the release of cortisol in the adrenals (PubMed:15864504). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (By similarity). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (By similarity). Mediates the transport of PAH, PCG, and the statins pravastatin and pitavastatin, from the cerebrum into the blood circulation across the blood-brain barrier (BBB). In summary, plays a role in the efflux of drugs and xenobiotics, helping reduce their undesired toxicological effects on the body (By similarity). {ECO:0000250|UniProtKB:O88909, ECO:0000250|UniProtKB:Q9R1U7, ECO:0000269|PubMed:11306713, ECO:0000269|PubMed:11669456, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:14586168, ECO:0000269|PubMed:14675047, ECO:0000269|PubMed:15644426, ECO:0000269|PubMed:15846473, ECO:0000269|PubMed:15864504, ECO:0000269|PubMed:16455804, ECO:0000269|PubMed:22108572, ECO:0000269|PubMed:23832370, ECO:0000269|PubMed:26377792, ECO:0000269|PubMed:28534121, ECO:0000269|PubMed:31553721, ECO:0000303|PubMed:15864504}.		monoatomic ion transport [GO:0006811]; prostaglandin transport [GO:0015732]; response to toxic substance [GO:0009636]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; solute:inorganic anion antiporter activity [GO:0005452]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; solute:inorganic anion antiporter activity [GO:0005452]; xenobiotic transmembrane transporter activity [GO:0042910]; monoatomic ion transport [GO:0006811]; prostaglandin transport [GO:0015732]; response to toxic substance [GO:0009636]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:11306713}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes on the brush border membrane of the choroid epithelial cells (By similarity). Localizes to the basolateral membrane of the proximal tubular cells (PubMed:11306713). Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9R1U7, ECO:0000269|PubMed:11306713}.
Q8TCD5	reviewed	NT5C_HUMAN	5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1)	NT5C DNT1 UMPH2	Homo sapiens (Human)	201	FUNCTION: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	allantoin metabolic process [GO:0000255]; amide catabolic process [GO:0043605]; dCMP catabolic process [GO:0006249]; dephosphorylation [GO:0016311]; dGMP catabolic process [GO:0046055]; dTMP catabolic process [GO:0046074]; dUMP catabolic process [GO:0046079]; IMP catabolic process [GO:0006204]; pyrimidine deoxyribonucleotide catabolic process [GO:0009223]; UMP catabolic process [GO:0046050]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	5'-nucleotidase activity [GO:0008253]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; metal ion binding [GO:0046872]; nucleotidase activity [GO:0008252]; pyrimidine nucleotide binding [GO:0019103]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; 5'-nucleotidase activity [GO:0008253]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; metal ion binding [GO:0046872]; nucleotidase activity [GO:0008252]; pyrimidine nucleotide binding [GO:0019103]; allantoin metabolic process [GO:0000255]; amide catabolic process [GO:0043605]; dCMP catabolic process [GO:0006249]; dephosphorylation [GO:0016311]; dGMP catabolic process [GO:0046055]; dTMP catabolic process [GO:0046074]; dUMP catabolic process [GO:0046079]; IMP catabolic process [GO:0006204]; pyrimidine deoxyribonucleotide catabolic process [GO:0009223]; UMP catabolic process [GO:0046050]	SUBCELLULAR LOCATION: Cytoplasm.
Q8TCE6	reviewed	DEN10_HUMAN	DENN domain-containing protein 10 (Protein FAM45A)	DENND10 FAM45A	Homo sapiens (Human)	357	FUNCTION: Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form. {ECO:0000269|PubMed:30771381}.		endosome transport via multivesicular body sorting pathway [GO:0032509]; protein transport [GO:0015031]; regulation of early endosome to late endosome transport [GO:2000641]	late endosome [GO:0005770]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	late endosome [GO:0005770]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; endosome transport via multivesicular body sorting pathway [GO:0032509]; protein transport [GO:0015031]; regulation of early endosome to late endosome transport [GO:2000641]	SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:30771381}.
Q8TCE9	reviewed	PPL13_HUMAN	Placental protein 13-like (Charcot-Leyden crystal protein 2) (CLC2) (Galectin-14) (Gal-14)	LGALS14 PPL13	Homo sapiens (Human)	139	FUNCTION: Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. {ECO:0000269|PubMed:19497882}.		apoptotic process [GO:0006915]	nucleoplasm [GO:0005654]	carbohydrate binding [GO:0030246]	nucleoplasm [GO:0005654]; carbohydrate binding [GO:0030246]; apoptotic process [GO:0006915]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11997112}.
Q8TCF1	reviewed	ZFAN1_HUMAN	AN1-type zinc finger protein 1 (Zinc finger AN1-type-containing protein 1)	ZFAND1	Homo sapiens (Human)	268	FUNCTION: Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830). {ECO:0000269|PubMed:29804830}.		cellular response to arsenite ion [GO:1903843]; positive regulation of intracellular protein transport [GO:0090316]; stress granule disassembly [GO:0035617]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]	proteasome binding [GO:0070628]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; proteasome binding [GO:0070628]; zinc ion binding [GO:0008270]; cellular response to arsenite ion [GO:1903843]; positive regulation of intracellular protein transport [GO:0090316]; stress granule disassembly [GO:0035617]	SUBCELLULAR LOCATION: Cytoplasm, Stress granule {ECO:0000269|PubMed:29804830}. Note=Colocalizes with TIA1, G3BP1, VCP and 26S proteasome in cytoplasmic stress granules (SGs) in response to arsenite-induced stress treatment in a VCP-independent manner (PubMed:29804830). Not localized in SGs in response to other heat- oxidative- or osmotic-induced stress treatments. Colocalizes with VCP in cytoplasmic speckles (PubMed:29804830). {ECO:0000269|PubMed:29804830}.
Q8TCG1	reviewed	CIP2A_HUMAN	Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen)	CIP2A KIAA1524	Homo sapiens (Human)	905	FUNCTION: Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation. {ECO:0000269|PubMed:17632056}.	MISCELLANEOUS: Antibodies against CIP2A are present in sera from many patients with gastric or prostate cancer, suggesting that it may act as a marker for such cancers. {ECO:0000269|PubMed:12118381, ECO:0000269|PubMed:15538718}.		cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; protein homodimerization activity [GO:0042803]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12118381}. Note=Slightly concentrates in the perinuclear region (PubMed:12118381). {ECO:0000269|PubMed:12118381}.
Q8TCG2	reviewed	P4K2B_HUMAN	Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA)	PI4K2B	Homo sapiens (Human)	481	FUNCTION: Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments (PubMed:11923287, PubMed:12324459). The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (PubMed:11923287, PubMed:12324459). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}.		endosome organization [GO:0007032]; Golgi organization [GO:0007030]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	1-phosphatidylinositol 4-kinase activity [GO:0004430]; ATP binding [GO:0005524]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; 1-phosphatidylinositol 4-kinase activity [GO:0004430]; ATP binding [GO:0005524]; endosome organization [GO:0007032]; Golgi organization [GO:0007030]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12324459}. Golgi apparatus membrane {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}; Peripheral membrane protein {ECO:0000269|PubMed:12324459}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12324459}. Cell membrane {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}. Early endosome membrane {ECO:0000269|PubMed:11923287}. Note=Mainly cytosolic, association with membranes of the Golgi, endoplasmic and plasma membrane is stimulated by active RAC1 (PubMed:12324459). Association with early endosomes has not been confirmed (PubMed:11923287, PubMed:12324459). {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}.
Q8TCG5	reviewed	CPT1C_HUMAN	Carnitine O-palmitoyltransferase 1, brain isoform (CPT1-B) (EC 2.3.1.21) (CPT IC) (Carnitine O-palmitoyltransferase I, brain isoform) (CPTI-B) (Carnitine palmitoyltransferase 1C)	CPT1C CATL1	Homo sapiens (Human)	803	FUNCTION: May play a role in lipid metabolic process. {ECO:0000269|PubMed:25751282}.		carnitine metabolic process [GO:0009437]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]	AMPA glutamate receptor complex [GO:0032281]; axon [GO:0030424]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; postsynapse [GO:0098794]	carnitine O-palmitoyltransferase activity [GO:0004095]	AMPA glutamate receptor complex [GO:0032281]; axon [GO:0030424]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; postsynapse [GO:0098794]; carnitine O-palmitoyltransferase activity [GO:0004095]; carnitine metabolic process [GO:0009437]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Synapse {ECO:0000250|UniProtKB:Q8BGD5}. Cell projection, dendrite {ECO:0000269|PubMed:25751282}. Cell projection, axon {ECO:0000269|PubMed:25751282}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8BGD5}. Note=Localized in the soma and dendritic and axonal projections. {ECO:0000269|PubMed:25751282}.
Q8TCI5	reviewed	CMAP3_HUMAN	Ciliary microtubule-associated protein 3 (Protein pitchfork)	CIMAP3 C1orf88 PIFO	Homo sapiens (Human)	191	FUNCTION: During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner. {ECO:0000269|PubMed:20643351}.		cilium organization [GO:0044782]; embryonic heart tube left/right pattern formation [GO:0060971]; positive regulation of kinase activity [GO:0033674]; regulation of cell projection organization [GO:0031344]	ciliary basal body [GO:0036064]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]	beta-tubulin binding [GO:0048487]; cytoskeletal protein binding [GO:0008092]; gamma-tubulin binding [GO:0043015]; kinesin binding [GO:0019894]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]	ciliary basal body [GO:0036064]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]; beta-tubulin binding [GO:0048487]; cytoskeletal protein binding [GO:0008092]; gamma-tubulin binding [GO:0043015]; kinesin binding [GO:0019894]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]; cilium organization [GO:0044782]; embryonic heart tube left/right pattern formation [GO:0060971]; positive regulation of kinase activity [GO:0033674]; regulation of cell projection organization [GO:0031344]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9D9W1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9D9W1}. Cytoplasm {ECO:0000250|UniProtKB:Q9D9W1}. Note=Accumulates specifically at the basal body and ciliary necklace during the early steps of cilia assembly and disassembly, when structural, functional and regulatory proteins are delivered to cilia. At S phase, accumulates in vesicles and declines during mitosis. {ECO:0000250|UniProtKB:Q9D9W1}.
Q8TCJ0	reviewed	FBX25_HUMAN	F-box only protein 25	FBXO25 FBX25	Homo sapiens (Human)	367	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). {ECO:0000250}.		protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]	actin binding [GO:0003779]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; actin binding [GO:0003779]; ubiquitin-protein transferase activity [GO:0004842]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16278047, ECO:0000269|PubMed:18287534}. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.
Q8TCJ2	reviewed	STT3B_HUMAN	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog)	STT3B SIMP	Homo sapiens (Human)	826	FUNCTION: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation (PubMed:19167329, PubMed:22607976). {ECO:0000250|UniProtKB:P39007, ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:31831667}.		co-translational protein modification [GO:0043686]; glycoprotein catabolic process [GO:0006516]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; oligosaccharyltransferase I complex [GO:0034998]; protein-containing complex [GO:0032991]	dolichyl-diphosphooligosaccharide-protein glycotransferase activity [GO:0004579]; metal ion binding [GO:0046872]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; oligosaccharyltransferase I complex [GO:0034998]; protein-containing complex [GO:0032991]; dolichyl-diphosphooligosaccharide-protein glycotransferase activity [GO:0004579]; metal ion binding [GO:0046872]; co-translational protein modification [GO:0043686]; glycoprotein catabolic process [GO:0006516]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:12887896}. Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P39007}.
Q8TCQ1	reviewed	MARH1_HUMAN	E3 ubiquitin-protein ligase MARCHF1 (EC 2.3.2.27) (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I) (RING finger protein 171) (RING-type E3 ubiquitin transferase MARCHF1)	MARCHF1 MARCH1 RNF171	Homo sapiens (Human)	289	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940}.		antigen processing and presentation of peptide antigen via MHC class II [GO:0002495]; immune response [GO:0006955]; protein polyubiquitination [GO:0000209]	cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	MHC protein binding [GO:0042287]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; MHC protein binding [GO:0042287]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; antigen processing and presentation of peptide antigen via MHC class II [GO:0002495]; immune response [GO:0006955]; protein polyubiquitination [GO:0000209]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q6NZQ8}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:19117940}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:19117940}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:19117940}; Multi-pass membrane protein {ECO:0000255}.
Q8TCS8	reviewed	PNPT1_HUMAN	Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)	PNPT1 PNPASE	Homo sapiens (Human)	783	FUNCTION: RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA. {ECO:0000269|PubMed:12473748, ECO:0000269|PubMed:12721301, ECO:0000269|PubMed:12798676, ECO:0000269|PubMed:16055741, ECO:0000269|PubMed:16410805, ECO:0000269|PubMed:16934922, ECO:0000269|PubMed:18083836, ECO:0000269|PubMed:18083837, ECO:0000269|PubMed:18501193, ECO:0000269|PubMed:19509288, ECO:0000269|PubMed:20547861, ECO:0000269|PubMed:20691904, ECO:0000269|PubMed:29967381}.		cellular response to interferon-beta [GO:0035458]; cellular response to oxidative stress [GO:0034599]; liver regeneration [GO:0097421]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA polyadenylation [GO:0097222]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrion morphogenesis [GO:0070584]; mRNA catabolic process [GO:0006402]; mRNA processing [GO:0006397]; negative regulation of growth [GO:0045926]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; positive regulation of mRNA catabolic process [GO:0061014]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; regulation of cell cycle [GO:0051726]; regulation of cellular respiration [GO:0043457]; regulation of cellular senescence [GO:2000772]; response to cAMP [GO:0051591]; response to growth hormone [GO:0060416]; RNA catabolic process [GO:0006401]; RNA import into mitochondrion [GO:0035927]; rRNA import into mitochondrion [GO:0035928]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial degradosome [GO:0045025]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; polysomal ribosome [GO:0042788]	3'-5'-RNA exonuclease activity [GO:0000175]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; polyribonucleotide nucleotidyltransferase activity [GO:0004654]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial degradosome [GO:0045025]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; polysomal ribosome [GO:0042788]; 3'-5'-RNA exonuclease activity [GO:0000175]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; polyribonucleotide nucleotidyltransferase activity [GO:0004654]; RNA binding [GO:0003723]; cellular response to interferon-beta [GO:0035458]; cellular response to oxidative stress [GO:0034599]; liver regeneration [GO:0097421]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA polyadenylation [GO:0097222]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrion morphogenesis [GO:0070584]; mRNA catabolic process [GO:0006402]; mRNA processing [GO:0006397]; negative regulation of growth [GO:0045926]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; positive regulation of mRNA catabolic process [GO:0061014]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; regulation of cell cycle [GO:0051726]; regulation of cellular respiration [GO:0043457]; regulation of cellular senescence [GO:2000772]; response to cAMP [GO:0051591]; response to growth hormone [GO:0060416]; RNA catabolic process [GO:0006401]; RNA import into mitochondrion [GO:0035927]; rRNA import into mitochondrion [GO:0035928]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16055741}. Mitochondrion matrix {ECO:0000269|PubMed:12798676, ECO:0000269|PubMed:16055741}. Mitochondrion intermembrane space {ECO:0000269|PubMed:16966381}; Peripheral membrane protein {ECO:0000269|PubMed:16966381}.
Q8TCT0	reviewed	CERK1_HUMAN	Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4)	CERK KIAA1646	Homo sapiens (Human)	537	FUNCTION: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:19168031). Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826). Binds phosphoinositides (PubMed:19168031). {ECO:0000269|PubMed:11956206, ECO:0000269|PubMed:16269826, ECO:0000269|PubMed:19168031}.		ceramide metabolic process [GO:0006672]; glycosphingolipid metabolic process [GO:0006687]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ceramide kinase activity [GO:0001729]; dihydroceramide kinase activity [GO:0102773]; magnesium ion binding [GO:0000287]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ceramide kinase activity [GO:0001729]; dihydroceramide kinase activity [GO:0102773]; magnesium ion binding [GO:0000287]; ceramide metabolic process [GO:0006672]; glycosphingolipid metabolic process [GO:0006687]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19168031}. Cell membrane {ECO:0000269|PubMed:16269826, ECO:0000269|PubMed:19168031}; Peripheral membrane protein {ECO:0000269|PubMed:19168031}.
Q8TCT1	reviewed	PHOP1_HUMAN	Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75)	PHOSPHO1	Homo sapiens (Human)	267	FUNCTION: Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (PubMed:15175005). Involved in the generation of inorganic phosphate for bone mineralization (By similarity). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity). {ECO:0000250|UniProtKB:Q8R2H9, ECO:0000269|PubMed:15175005}.		bone mineralization [GO:0030282]; bone mineralization involved in bone maturation [GO:0035630]; endochondral ossification [GO:0001958]; regulation of bone mineralization [GO:0030500]	cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular membrane-bounded organelle [GO:0065010]	metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; phosphocholine phosphatase activity [GO:0052731]; phosphoethanolamine phosphatase activity [GO:0052732]; pyrophosphatase activity [GO:0016462]	cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular membrane-bounded organelle [GO:0065010]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; phosphocholine phosphatase activity [GO:0052731]; phosphoethanolamine phosphatase activity [GO:0052732]; pyrophosphatase activity [GO:0016462]; bone mineralization [GO:0030282]; bone mineralization involved in bone maturation [GO:0035630]; endochondral ossification [GO:0001958]; regulation of bone mineralization [GO:0030500]	SUBCELLULAR LOCATION: Extracellular vesicle {ECO:0000250|UniProtKB:Q8R2H9}. Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. {ECO:0000250|UniProtKB:Q8R2H9}.
Q8TCT6	reviewed	SPPL3_HUMAN	Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4)	SPPL3 IMP2 PSL4	Homo sapiens (Human)	384	FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971). {ECO:0000269|PubMed:16873890, ECO:0000269|PubMed:23132852, ECO:0000269|PubMed:25354954, ECO:0000269|PubMed:25384971, ECO:0000269|PubMed:25827571}.		membrane protein proteolysis [GO:0033619]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein binding [GO:0032092]; positive regulation of protein dephosphorylation [GO:0035307]; signal peptide processing [GO:0006465]; T cell receptor signaling pathway [GO:0050852]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]	aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]; membrane protein proteolysis [GO:0033619]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein binding [GO:0032092]; positive regulation of protein dephosphorylation [GO:0035307]; signal peptide processing [GO:0006465]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15998642}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:16829952}. Membrane {ECO:0000269|PubMed:15385547}; Multi-pass membrane protein {ECO:0000305}; Lumenal side {ECO:0000269|PubMed:15385547}.
Q8TCT7	reviewed	SPP2B_HUMAN	Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1)	SPPL2B IMP4 KIAA1532 PSL1	Homo sapiens (Human)	592	FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17965014, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:22194595, ECO:0000269|PubMed:23132852}.		membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; regulation of immune response [GO:0050776]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]	actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]	actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; regulation of immune response [GO:0050776]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16829952}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:17965014}; Multi-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:15998642}; Multi-pass membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:15998642}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:15385547}; Multi-pass membrane protein {ECO:0000305}; Lumenal side {ECO:0000269|PubMed:15385547}. Note=targeted through the entire secretory pathway to endosomes/lysosomes (PubMed:15998642). {ECO:0000269|PubMed:15998642}.
Q8TCT8	reviewed	SPP2A_HUMAN	Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)	SPPL2A IMP3 PSL2 PSEC0147	Homo sapiens (Human)	520	FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). Essential for degradation of the invariant chain CD74 that plays a central role in the function of antigen-presenting cells in the immune system (By similarity). Plays a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). {ECO:0000250|UniProtKB:Q9JJF9, ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:17965014, ECO:0000269|PubMed:23132852}.		membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; regulation of immune response [GO:0050776]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; extracellular exosome [GO:0070062]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; extracellular exosome [GO:0070062]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; regulation of immune response [GO:0050776]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:16829952}; Multi-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000250|UniProtKB:Q9JJF9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JJF9}. Membrane {ECO:0000269|PubMed:15385547}; Multi-pass membrane protein {ECO:0000305}; Lumenal side {ECO:0000269|PubMed:15385547}. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.
Q8TCT9	reviewed	HM13_HUMAN	Minor histocompatibility antigen H13 (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase)	HM13 H13 IMP1 PSL3 SPP MSTP086	Homo sapiens (Human)	377	FUNCTION: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity). {ECO:0000250|UniProtKB:Q9D8V0, ECO:0000269|PubMed:11714810, ECO:0000269|PubMed:12077416, ECO:0000269|PubMed:12145199, ECO:0000269|PubMed:14741365, ECO:0000269|PubMed:25239945}.		cellular response to oxidative stress [GO:0034599]; in utero embryonic development [GO:0001701]; membrane protein proteolysis [GO:0033619]; membrane protein proteolysis involved in retrograde protein transport, ER to cytosol [GO:1904211]; signal peptide processing [GO:0006465]	cell surface [GO:0009986]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]	aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase binding [GO:0031625]	cell surface [GO:0009986]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase binding [GO:0031625]; cellular response to oxidative stress [GO:0034599]; in utero embryonic development [GO:0001701]; membrane protein proteolysis [GO:0033619]; membrane protein proteolysis involved in retrograde protein transport, ER to cytosol [GO:1904211]; signal peptide processing [GO:0006465]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15998642}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:12077416, ECO:0000269|PubMed:15385547}; Multi-pass membrane protein {ECO:0000305}; Lumenal side {ECO:0000269|PubMed:12077416, ECO:0000269|PubMed:15385547}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000250|UniProtKB:Q9D8V0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9D8V0}.
Q8TCU3	reviewed	S7A13_HUMAN	Solute carrier family 7 member 13 (Sodium-independent aspartate/glutamate transporter 1) (X-amino acid transporter 2)	SLC7A13 AGT1 XAT2	Homo sapiens (Human)	470	FUNCTION: Associates with SLC3A1/rBAT to form a functional heterodimeric complex that transports anionic and neutral amino acids across the apical plasma membrane of renal epithelium. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. May act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate. {ECO:0000250|UniProtKB:Q91WN3}.		amino acid transmembrane transport [GO:0003333]; aspartate transmembrane transport [GO:0015810]; L-cystine transport [GO:0015811]; L-glutamate transmembrane transport [GO:0015813]	apical plasma membrane [GO:0016324]	antiporter activity [GO:0015297]; L-amino acid transmembrane transporter activity [GO:0015179]; protein heterodimerization activity [GO:0046982]	apical plasma membrane [GO:0016324]; antiporter activity [GO:0015297]; L-amino acid transmembrane transporter activity [GO:0015179]; protein heterodimerization activity [GO:0046982]; amino acid transmembrane transport [GO:0003333]; aspartate transmembrane transport [GO:0015810]; L-cystine transport [GO:0015811]; L-glutamate transmembrane transport [GO:0015813]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q91WN3}; Multi-pass membrane protein {ECO:0000255}.
Q8TCU4	reviewed	ALMS1_HUMAN	Centrosome-associated protein ALMS1 (Alstrom syndrome protein 1)	ALMS1 KIAA0328	Homo sapiens (Human)	4168	FUNCTION: Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells. {ECO:0000269|PubMed:17954613}.		endosomal transport [GO:0016197]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of centriole replication [GO:0046599]; regulation of stress fiber assembly [GO:0051492]	centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; spindle pole [GO:0000922]	microtubule binding [GO:0008017]	centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; spindle pole [GO:0000922]; microtubule binding [GO:0008017]; endosomal transport [GO:0016197]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of centriole replication [GO:0046599]; regulation of stress fiber assembly [GO:0051492]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole. Note=Associated with centrosomes and basal bodies at the base of primary cilia. Specifically locates to the proximal ends of centrioles and basal bodies. Colocalizes partially with NCAPD2 at these sites. During mitosis localizes to both spindle poles.
Q8TCU5	reviewed	NMD3A_HUMAN	Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L)	GRIN3A KIAA1973	Homo sapiens (Human)	1115	FUNCTION: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role in PPP2CB-NMDAR mediated signaling mechanism. {ECO:0000250|UniProtKB:Q9R1M7}.		calcium ion transport [GO:0006816]; dendrite development [GO:0016358]; ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine development [GO:0061000]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to ethanol [GO:0045471]; rhythmic process [GO:0048511]; synaptic transmission, glutamatergic [GO:0035249]	endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; synapse [GO:0045202]	calcium channel activity [GO:0005262]; glutamate receptor activity [GO:0008066]; glycine binding [GO:0016594]; identical protein binding [GO:0042802]; neurotransmitter binding [GO:0042165]; NMDA glutamate receptor activity [GO:0004972]; protein phosphatase 2A binding [GO:0051721]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; synapse [GO:0045202]; calcium channel activity [GO:0005262]; glutamate receptor activity [GO:0008066]; glycine binding [GO:0016594]; identical protein binding [GO:0042802]; neurotransmitter binding [GO:0042165]; NMDA glutamate receptor activity [GO:0004972]; protein phosphatase 2A binding [GO:0051721]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; calcium ion transport [GO:0006816]; dendrite development [GO:0016358]; ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine development [GO:0061000]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to ethanol [GO:0045471]; rhythmic process [GO:0048511]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9R1M7}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}. Postsynaptic density {ECO:0000250}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity). {ECO:0000250}.
Q8TCU6	reviewed	PREX1_HUMAN	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)	PREX1 KIAA1415	Homo sapiens (Human)	1659	FUNCTION: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.		actin filament polymerization [GO:0030041]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell migration [GO:0030335]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of actin filament polymerization [GO:0030833]; regulation of dendrite development [GO:0050773]; regulation of signaling [GO:0023051]; regulation of small GTPase mediated signal transduction [GO:0051056]; superoxide metabolic process [GO:0006801]; T cell differentiation [GO:0030217]	cytosol [GO:0005829]; dendritic shaft [GO:0043198]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; dendritic shaft [GO:0043198]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543]; actin filament polymerization [GO:0030041]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell migration [GO:0030335]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of actin filament polymerization [GO:0030833]; regulation of dendrite development [GO:0050773]; regulation of signaling [GO:0023051]; regulation of small GTPase mediated signal transduction [GO:0051056]; superoxide metabolic process [GO:0006801]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
Q8TCX1	reviewed	DC2L1_HUMAN	Cytoplasmic dynein 2 light intermediate chain 1 (Dynein 2 light intermediate chain)	DYNC2LI1 D2LIC LIC3 CGI-60	Homo sapiens (Human)	351	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles (PubMed:29742051). Involved in the regulation of ciliary length (PubMed:26077881, PubMed:26130459). {ECO:0000269|PubMed:26077881, ECO:0000269|PubMed:26130459, ECO:0000269|PubMed:29742051}.		determination of left/right symmetry [GO:0007368]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of cilium assembly [GO:1902017]	apical part of cell [GO:0045177]; axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; motile cilium [GO:0031514]	dynein heavy chain binding [GO:0045504]	apical part of cell [GO:0045177]; axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; motile cilium [GO:0031514]; dynein heavy chain binding [GO:0045504]; determination of left/right symmetry [GO:0007368]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of cilium assembly [GO:1902017]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:11907264}. Cytoplasm {ECO:0000269|PubMed:26130459}. Cell projection, cilium {ECO:0000269|PubMed:26130459, ECO:0000269|PubMed:29742051}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:26130459, ECO:0000269|PubMed:29742051}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q8K0T2}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26130459}. Note=Localizes to the apical cytoplasm. {ECO:0000250|UniProtKB:Q8K0T2}.
Q8TCX5	reviewed	RHPN1_HUMAN	Rhophilin-1 (GTP-Rho-binding protein 1)	RHPN1 KIAA1929	Homo sapiens (Human)	670	FUNCTION: Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules. {ECO:0000250|UniProtKB:Q61085}.		negative regulation of stress fiber assembly [GO:0051497]; proteolysis [GO:0006508]; signal transduction [GO:0007165]	cytosol [GO:0005829]		cytosol [GO:0005829]; negative regulation of stress fiber assembly [GO:0051497]; proteolysis [GO:0006508]; signal transduction [GO:0007165]	
Q8TCY5	reviewed	MRAP_HUMAN	Melanocortin-2 receptor accessory protein (B27) (Fat cell-specific low molecular weight protein) (Fat tissue-specific low MW protein)	MRAP C21orf61 FALP	Homo sapiens (Human)	172	FUNCTION: Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. {ECO:0000269|PubMed:15654338, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.		negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; protein localization to plasma membrane [GO:0072659]; regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106070]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	corticotropin hormone receptor binding [GO:0031780]; identical protein binding [GO:0042802]; signaling receptor regulator activity [GO:0030545]; type 1 melanocortin receptor binding [GO:0070996]; type 3 melanocortin receptor binding [GO:0031781]; type 4 melanocortin receptor binding [GO:0031782]; type 5 melanocortin receptor binding [GO:0031783]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; corticotropin hormone receptor binding [GO:0031780]; identical protein binding [GO:0042802]; signaling receptor regulator activity [GO:0030545]; type 1 melanocortin receptor binding [GO:0070996]; type 3 melanocortin receptor binding [GO:0031781]; type 4 melanocortin receptor binding [GO:0031782]; type 5 melanocortin receptor binding [GO:0031783]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; protein localization to plasma membrane [GO:0072659]; regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106070]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15654338}; Single-pass membrane protein {ECO:0000269|PubMed:15654338}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15654338}; Single-pass membrane protein {ECO:0000269|PubMed:15654338}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm. {ECO:0000269|PubMed:20371771}.
Q8TCY9	reviewed	URGCP_HUMAN	Up-regulator of cell proliferation (HBV X protein up-regulated gene 4 protein) (HBxAg up-regulated gene 4 protein)	URGCP KIAA1507 URG4	Homo sapiens (Human)	931	FUNCTION: May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}.		cell cycle [GO:0007049]	cytosol [GO:0005829]; nucleus [GO:0005634]	GTP binding [GO:0005525]	cytosol [GO:0005829]; nucleus [GO:0005634]; GTP binding [GO:0005525]; cell cycle [GO:0007049]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}. Nucleus {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}. Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.
Q8TCZ2	reviewed	C99L2_HUMAN	CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99)	CD99L2 MIC2L1 UNQ1964/PRO4486	Homo sapiens (Human)	262	FUNCTION: Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; diapedesis [GO:0050904]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of T cell extravasation [GO:2000409]	adherens junction [GO:0005912]; cell surface [GO:0009986]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]		adherens junction [GO:0005912]; cell surface [GO:0009986]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; cell adhesion [GO:0007155]; diapedesis [GO:0050904]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of T cell extravasation [GO:2000409]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell junction {ECO:0000250}. Secreted {ECO:0000269|PubMed:25326458}.
Q8TD06	reviewed	AGR3_HUMAN	Anterior gradient protein 3 (AG-3) (AG3) (hAG-3) (Anterior gradient 3 homolog) (Breast cancer membrane protein 11) (Protein disulfide isomerase family A, member 18)	AGR3 BCMP11 PDIA18 UNQ642/PRO1272	Homo sapiens (Human)	166	FUNCTION: Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells. {ECO:0000250|UniProtKB:Q8R3W7}.			endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]	dystroglycan binding [GO:0002162]	endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; dystroglycan binding [GO:0002162]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:18086916, ECO:0000269|PubMed:25751668}. Note=Found in the cytoplasm, which could include the endoplasmic reticulum. {ECO:0000305|PubMed:26170690}.
Q8TD07	reviewed	RAE1E_HUMAN	Retinoic acid early transcript 1E (Lymphocyte effector toxicity activation ligand) (NKG2D ligand 4) (N2DL-4) (NKG2DL4) (RAE-1-like transcript 4) (UL16-binding protein 4)	RAET1E LETAL N2DL4 ULBP4 UNQ1867/PRO4303	Homo sapiens (Human)	263	FUNCTION: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:18544572}.	MISCELLANEOUS: UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain. {ECO:0000305}.	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	natural killer cell lectin-like receptor binding [GO:0046703]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; natural killer cell lectin-like receptor binding [GO:0046703]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15240696}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.
Q8TD08	reviewed	MK15_HUMAN	Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)	MAPK15 ERK7 ERK8	Homo sapiens (Human)	544	FUNCTION: Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:20638370, PubMed:19166846). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}.	MISCELLANEOUS: [Isoform 2]: Appears not to be a CSK- and RET-dependent activated kinase. {ECO:0000305}.	DNA damage response [GO:0006974]; dopamine uptake [GO:0090494]; endoplasmic reticulum organization [GO:0007029]; intracellular signal transduction [GO:0035556]; negative regulation of cell migration [GO:0030336]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of metaphase/anaphase transition of meiosis I [GO:1905188]; positive regulation of spindle assembly [GO:1905832]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; protein localization to ciliary transition zone [GO:1904491]; regulation of autophagy [GO:0010506]; regulation of cilium assembly [GO:1902017]; regulation of COPII vesicle coating [GO:0003400]	autophagosome [GO:0005776]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; meiotic spindle [GO:0072687]; nucleus [GO:0005634]	ATP binding [GO:0005524]; chromatin binding [GO:0003682]; kinase activity [GO:0016301]; MAP kinase activity [GO:0004707]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; SH3 domain binding [GO:0017124]	autophagosome [GO:0005776]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; meiotic spindle [GO:0072687]; nucleus [GO:0005634]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; kinase activity [GO:0016301]; MAP kinase activity [GO:0004707]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; SH3 domain binding [GO:0017124]; DNA damage response [GO:0006974]; dopamine uptake [GO:0090494]; endoplasmic reticulum organization [GO:0007029]; intracellular signal transduction [GO:0035556]; negative regulation of cell migration [GO:0030336]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of metaphase/anaphase transition of meiosis I [GO:1905188]; positive regulation of spindle assembly [GO:1905832]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; protein localization to ciliary transition zone [GO:1904491]; regulation of autophagy [GO:0010506]; regulation of cilium assembly [GO:1902017]; regulation of COPII vesicle coating [GO:0003400]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:29021280}. Cell junction, tight junction {ECO:0000269|PubMed:29021280}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:29021280}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:22948227}. Golgi apparatus {ECO:0000269|PubMed:24618899}. Nucleus {ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:21190936}. Cytoplasm {ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:21190936}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q80Y86}. Note=Co-localizes to the cytoplasm only in presence of ESRRA (PubMed:21190936). Translocates to the nucleus upon activation (PubMed:20638370). At prometaphase I, metaphase I (MI), anaphase I, telophase I, and metaphase II (MII) stages, is stably detected at the spindle (By similarity). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:21190936}.
Q8TD10	reviewed	MIPO1_HUMAN	Mirror-image polydactyly gene 1 protein	MIPOL1	Homo sapiens (Human)	442		MISCELLANEOUS: [Isoform 3]: May be due to a competing acceptor splice site. {ECO:0000305}.		nucleus [GO:0005634]	identical protein binding [GO:0042802]	nucleus [GO:0005634]; identical protein binding [GO:0042802]	
Q8TD16	reviewed	BICD2_HUMAN	Protein bicaudal D homolog 2 (Bic-D 2)	BICD2 KIAA0699	Homo sapiens (Human)	824	FUNCTION: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}.	MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.	centrosome localization [GO:0051642]; microtubule anchoring at microtubule organizing center [GO:0072393]; microtubule-based movement [GO:0007018]; minus-end-directed organelle transport along microtubule [GO:0072385]; mRNA transport [GO:0051028]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; regulation of microtubule cytoskeleton organization [GO:0070507]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	annulate lamellae [GO:0005642]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]	cytoskeletal anchor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein light intermediate chain binding [GO:0051959]; small GTPase binding [GO:0031267]	annulate lamellae [GO:0005642]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]; cytoskeletal anchor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein light intermediate chain binding [GO:0051959]; small GTPase binding [GO:0031267]; centrosome localization [GO:0051642]; microtubule anchoring at microtubule organizing center [GO:0072393]; microtubule-based movement [GO:0007018]; minus-end-directed organelle transport along microtubule [GO:0072385]; mRNA transport [GO:0051028]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; regulation of microtubule cytoskeleton organization [GO:0070507]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:23664116, ECO:0000269|PubMed:23664119}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11864968}. Cytoplasm {ECO:0000269|PubMed:23664116, ECO:0000269|PubMed:23664120}. Nucleus envelope {ECO:0000269|PubMed:20386726}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:20386726}. Note=In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (By similarity). Localizes to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae in a RANBP2-dependent manner during G2 phase of the cell cycle (PubMed:20386726). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:20386726}.
Q8TD17	reviewed	ZN398_HUMAN	Zinc finger protein 398 (Zinc finger DNA-binding protein p52/p71)	ZNF398 KIAA1339 ZER6	Homo sapiens (Human)	642	FUNCTION: Functions as a transcriptional activator.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TD19	reviewed	NEK9_HUMAN	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8)	NEK9 KIAA1995 NEK8 NERCC	Homo sapiens (Human)	979	FUNCTION: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}.		cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; phosphorylation [GO:0016310]; regulation of mitotic cell cycle [GO:0007346]	cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; phosphorylation [GO:0016310]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14660563}. Nucleus {ECO:0000269|PubMed:14660563}.
Q8TD22	reviewed	SFXN5_HUMAN	Sideroflexin-5	SFXN5	Homo sapiens (Human)	340	FUNCTION: Mitochondrial amino-acid transporter (By similarity). Transports citrate (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (PubMed:30442778) (By similarity). In brown adipose tissue, plays a role in the regulation of UCP1-dependent thermogenesis probably by supporting mitochondrial glycerol-3-phosphate utilization (By similarity). {ECO:0000250|UniProtKB:Q8CFD0, ECO:0000250|UniProtKB:Q925N0, ECO:0000250|UniProtKB:Q9H9B4, ECO:0000269|PubMed:30442778}.		amino acid transport [GO:0006865]; citrate transport [GO:0015746]; mitochondrial transmembrane transport [GO:1990542]; positive regulation of cold-induced thermogenesis [GO:0120162]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	citrate transmembrane transporter activity [GO:0015137]; monoatomic ion transmembrane transporter activity [GO:0015075]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; citrate transmembrane transporter activity [GO:0015137]; monoatomic ion transmembrane transporter activity [GO:0015075]; amino acid transport [GO:0006865]; citrate transport [GO:0015746]; mitochondrial transmembrane transport [GO:1990542]; positive regulation of cold-induced thermogenesis [GO:0120162]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30442778}; Multi-pass membrane protein {ECO:0000255}.
Q8TD23	reviewed	ZN675_HUMAN	Zinc finger protein 675 (TRAF6-binding zinc finger protein) (TRAF6-inhibitory zinc finger protein)	ZNF675 TIZ	Homo sapiens (Human)	568	FUNCTION: May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.		bone resorption [GO:0045453]; canonical NF-kappaB signal transduction [GO:0007249]; cytokine-mediated signaling pathway [GO:0019221]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; bone resorption [GO:0045453]; canonical NF-kappaB signal transduction [GO:0007249]; cytokine-mediated signaling pathway [GO:0019221]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TD26	reviewed	CHD6_HUMAN	Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.12) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)	CHD6 CHD5 KIAA1335 RIGB	Homo sapiens (Human)	2715	FUNCTION: DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}.		cell redox homeostasis [GO:0045454]; chromatin remodeling [GO:0006338]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; transcription coregulator binding [GO:0001221]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; transcription coregulator binding [GO:0001221]; cell redox homeostasis [GO:0045454]; chromatin remodeling [GO:0006338]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:21899694}. Note=Enriched at sites of mRNA synthesis (PubMed:17027977). During influenza A virus infection, localizes to inactive chromatin. {ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:21899694}.
Q8TD30	reviewed	ALAT2_HUMAN	Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2)	GPT2 AAT2 ALT2	Homo sapiens (Human)	523	FUNCTION: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. {ECO:0000269|PubMed:11863375}.		2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; cellular response to insulin stimulus [GO:0032869]; L-alanine catabolic process [GO:0042853]; L-alanine metabolic process [GO:0042851]; positive regulation of gluconeogenesis [GO:0045722]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]	extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]	L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]	extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]; 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; cellular response to insulin stimulus [GO:0032869]; L-alanine catabolic process [GO:0042853]; L-alanine metabolic process [GO:0042851]; positive regulation of gluconeogenesis [GO:0045722]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]	
Q8TD31	reviewed	CCHCR_HUMAN	Coiled-coil alpha-helical rod protein 1 (Alpha-helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8)	CCHCR1 C6orf18 HCR	Homo sapiens (Human)	782	FUNCTION: May be a regulator of keratinocyte proliferation or differentiation.		cell differentiation [GO:0030154]; protein export from nucleus [GO:0006611]	centriole [GO:0005814]; cytosol [GO:0005829]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	centriole [GO:0005814]; cytosol [GO:0005829]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; cell differentiation [GO:0030154]; protein export from nucleus [GO:0006611]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q8TD43	reviewed	TRPM4_HUMAN	Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4)	TRPM4 LTRPC4	Homo sapiens (Human)	1214	FUNCTION: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822). {ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:14758478, ECO:0000269|PubMed:15121803, ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:15550671, ECO:0000269|PubMed:15590641, ECO:0000269|PubMed:15845551, ECO:0000269|PubMed:16186107, ECO:0000269|PubMed:16407466, ECO:0000269|PubMed:16424899, ECO:0000269|PubMed:16806463, ECO:0000269|PubMed:20625999, ECO:0000269|PubMed:20656926, ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:30528822}.		adaptive immune response [GO:0002250]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; dendritic cell chemotaxis [GO:0002407]; inorganic cation transmembrane transport [GO:0098662]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; negative regulation of bone mineralization [GO:0030502]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of atrial cardiac muscle cell action potential [GO:1903949]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of heart rate [GO:0010460]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization [GO:1904199]; positive regulation of vasoconstriction [GO:0045907]; protein homotetramerization [GO:0051289]; protein sumoylation [GO:0016925]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of T cell cytokine production [GO:0002724]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; sodium ion import across plasma membrane [GO:0098719]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]	ATP binding [GO:0005524]; calcium activated cation channel activity [GO:0005227]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]; sodium channel activity [GO:0005272]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]; ATP binding [GO:0005524]; calcium activated cation channel activity [GO:0005227]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]; sodium channel activity [GO:0005272]; adaptive immune response [GO:0002250]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; dendritic cell chemotaxis [GO:0002407]; inorganic cation transmembrane transport [GO:0098662]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; negative regulation of bone mineralization [GO:0030502]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of atrial cardiac muscle cell action potential [GO:1903949]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of heart rate [GO:0010460]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization [GO:1904199]; positive regulation of vasoconstriction [GO:0045907]; protein homotetramerization [GO:0051289]; protein sumoylation [GO:0016925]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of T cell cytokine production [GO:0002724]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; sodium ion import across plasma membrane [GO:0098719]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15590641, ECO:0000269|PubMed:19945433, ECO:0000269|PubMed:29211723}; Multi-pass membrane protein {ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581}. Endoplasmic reticulum {ECO:0000269|PubMed:19945433}. Golgi apparatus {ECO:0000269|PubMed:19945433}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11535825}. Endoplasmic reticulum. Golgi apparatus.
Q8TD46	reviewed	MO2R1_HUMAN	Cell surface glycoprotein CD200 receptor 1 (CD200 cell surface glycoprotein receptor) (Cell surface glycoprotein OX2 receptor 1)	CD200R1 CD200R CRTR2 MOX2R OX2R UNQ2522/PRO6015	Homo sapiens (Human)	348	FUNCTION: Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. {ECO:0000269|PubMed:12960329}.		heterotypic cell-cell adhesion [GO:0034113]; intracellular signal transduction [GO:0035556]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage migration [GO:1905522]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of T cell migration [GO:2000405]; regulation of neuroinflammatory response [GO:0150077]; signal transduction [GO:0007165]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	glycosylated region protein binding [GO:0140081]; immunoglobulin receptor activity [GO:0019763]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; glycosylated region protein binding [GO:0140081]; immunoglobulin receptor activity [GO:0019763]; signaling receptor activity [GO:0038023]; heterotypic cell-cell adhesion [GO:0034113]; intracellular signal transduction [GO:0035556]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage migration [GO:1905522]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of T cell migration [GO:2000405]; regulation of neuroinflammatory response [GO:0150077]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Q8TD57	reviewed	DYH3_HUMAN	Dynein axonemal heavy chain 3 (Axonemal beta dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b)	DNAH3 DNAHC3B	Homo sapiens (Human)	4116	FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.		cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]	9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; dynein complex [GO:0030286]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; dynein complex [GO:0030286]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]; cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}.
Q8TD84	reviewed	DSCL1_HUMAN	Cell adhesion molecule DSCAML1 (Down syndrome cell adhesion molecule 2) (Down syndrome cell adhesion molecule-like protein 1)	DSCAML1 DSCAM2 KIAA1132	Homo sapiens (Human)	2053	FUNCTION: Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). {ECO:0000250|UniProtKB:E1C8P7, ECO:0000250|UniProtKB:Q4VA61, ECO:0000269|PubMed:11453658}.		axon guidance [GO:0007411]; axonogenesis [GO:0007409]; brain development [GO:0007420]; cell fate determination [GO:0001709]; central nervous system development [GO:0007417]; dendrite self-avoidance [GO:0070593]; dorsal/ventral pattern formation [GO:0009953]; embryonic skeletal system morphogenesis [GO:0048704]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	axon [GO:0030424]; cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; synapse [GO:0045202]	cell-cell adhesion mediator activity [GO:0098632]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; synapse [GO:0045202]; cell-cell adhesion mediator activity [GO:0098632]; protein homodimerization activity [GO:0042803]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; brain development [GO:0007420]; cell fate determination [GO:0001709]; central nervous system development [GO:0007417]; dendrite self-avoidance [GO:0070593]; dorsal/ventral pattern formation [GO:0009953]; embryonic skeletal system morphogenesis [GO:0048704]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11453658}; Single-pass type I membrane protein {ECO:0000305}. Synapse {ECO:0000250|UniProtKB:E1C8P7}.
Q8TD91	reviewed	MAGC3_HUMAN	Melanoma-associated antigen C3 (Cancer/testis antigen 7.2) (CT7.2) (Hepatocellular carcinoma-associated antigen 2) (MAGE-C3 antigen)	MAGEC3 HCA2	Homo sapiens (Human)	643			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
Q8TDB4	reviewed	HUMMR_HUMAN	Protein MGARP (Corneal endothelium-specific protein 1) (CESP-1) (Hypoxia up-regulated mitochondrial movement regulator protein) (Mitochondria-localized glutamic acid-rich protein) (Ovary-specific acidic protein)	MGARP C4orf49 CESP1 HUMMR OSAP GS3582	Homo sapiens (Human)	240	FUNCTION: Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). Plays an inhibitory role during neocortex development by regulating mitochondrial morphology, distribution and motility in neocortical neurons (By similarity). {ECO:0000250|UniProtKB:Q8VI64}.		anterograde axonal transport [GO:0008089]; axon development [GO:0061564]; axonal transport of mitochondrion [GO:0019896]; cellular response to gonadotropin-releasing hormone [GO:0097211]; cellular response to hypoxia [GO:0071456]; cellular response to steroid hormone stimulus [GO:0071383]; cerebral cortex development [GO:0021987]; negative regulation of dendrite development [GO:2000171]; positive regulation of mitochondrion organization [GO:0010822]; protein targeting to mitochondrion [GO:0006626]; regulation of mitochondrion organization [GO:0010821]; retrograde axonal transport [GO:0008090]	axon cytoplasm [GO:1904115]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		axon cytoplasm [GO:1904115]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; anterograde axonal transport [GO:0008089]; axon development [GO:0061564]; axonal transport of mitochondrion [GO:0019896]; cellular response to gonadotropin-releasing hormone [GO:0097211]; cellular response to hypoxia [GO:0071456]; cellular response to steroid hormone stimulus [GO:0071383]; cerebral cortex development [GO:0021987]; negative regulation of dendrite development [GO:2000171]; positive regulation of mitochondrion organization [GO:0010822]; protein targeting to mitochondrion [GO:0006626]; regulation of mitochondrion organization [GO:0010821]; retrograde axonal transport [GO:0008090]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16565373, ECO:0000269|PubMed:21447634}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8VI64}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8VI64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8VI64}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8VI64}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8VI64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8VI64}. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion. {ECO:0000250|UniProtKB:Q8VI64}.
Q8TDB6	reviewed	DTX3L_HUMAN	E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)	DTX3L BBAP	Homo sapiens (Human)	740	FUNCTION: E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteasomal-mediated degradation (PubMed:26479788). {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}.		defense response to virus [GO:0051607]; DNA damage checkpoint signaling [GO:0000077]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; endosome to lysosome transport [GO:0008333]; innate immune response [GO:0045087]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; Notch signaling pathway [GO:0007219]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor catabolic process [GO:2000646]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein transport [GO:0015031]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone ubiquitin ligase activity [GO:0140852]; metal ion binding [GO:0046872]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]; STAT family protein binding [GO:0097677]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone ubiquitin ligase activity [GO:0140852]; metal ion binding [GO:0046872]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]; STAT family protein binding [GO:0097677]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-protein transferase activity [GO:0004842]; defense response to virus [GO:0051607]; DNA damage checkpoint signaling [GO:0000077]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; endosome to lysosome transport [GO:0008333]; innate immune response [GO:0045087]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; Notch signaling pathway [GO:0007219]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor catabolic process [GO:2000646]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein transport [GO:0015031]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788}. Nucleus {ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:26479788}. Early endosome membrane {ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:24790097}. Lysosome membrane {ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:24790097}. Note=Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788). Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272). Localization to early endosomes is increased upon CXCL12 stimulation where it co-localizes with ITCH, CXCL4, HGS and STAM (PubMed:24790097). A minor proportion localizes to lysosomes (PubMed:24790097). {ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788}.
Q8TDB8	reviewed	GTR14_HUMAN	Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14)	SLC2A14 GLUT14	Homo sapiens (Human)	520	FUNCTION: Hexose transporter that can mediate the transport of glucose and dehydroascorbate across the cell membrane. {ECO:0000269|PubMed:28971850}.	MISCELLANEOUS: GLUT14 is a recent (less than 5 M year old) duplication of GLUT3. {ECO:0000305|PubMed:12504846}.	cell differentiation [GO:0030154]; dehydroascorbic acid transport [GO:0070837]; glucose import [GO:0046323]; glucose transmembrane transport [GO:1904659]; spermatogenesis [GO:0007283]	aggresome [GO:0016235]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; glucose transmembrane transporter activity [GO:0005355]	aggresome [GO:0016235]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; glucose transmembrane transporter activity [GO:0005355]; cell differentiation [GO:0030154]; dehydroascorbic acid transport [GO:0070837]; glucose import [GO:0046323]; glucose transmembrane transport [GO:1904659]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27460888}; Multi-pass membrane protein {ECO:0000255}.
Q8TDC0	reviewed	MYOZ3_HUMAN	Myozenin-3 (Calsarcin-3) (FATZ-related protein 3)	MYOZ3 FRP3	Homo sapiens (Human)	251	FUNCTION: Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.			actin cytoskeleton [GO:0015629]; Z disc [GO:0030018]	actin binding [GO:0003779]; FATZ binding [GO:0051373]; telethonin binding [GO:0031433]	actin cytoskeleton [GO:0015629]; Z disc [GO:0030018]; actin binding [GO:0003779]; FATZ binding [GO:0051373]; telethonin binding [GO:0031433]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Localized at the Z-line of skeletal muscle. {ECO:0000250}.
Q8TDC3	reviewed	BRSK1_HUMAN	Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1)	BRSK1 KIAA1811 SAD1 SADB	Homo sapiens (Human)	778	FUNCTION: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}.		associative learning [GO:0008306]; axonogenesis [GO:0007409]; centrosome duplication [GO:0051298]; DNA damage response [GO:0006974]; establishment of cell polarity [GO:0030010]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; neuron differentiation [GO:0030182]; neurotransmitter secretion [GO:0007269]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of neuron projection development [GO:0010975]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle clustering [GO:2000807]; response to UV [GO:0009411]; synaptic vesicle cycle [GO:0099504]	cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; distal axon [GO:0150034]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021]	ATP binding [GO:0005524]; gamma-tubulin binding [GO:0043015]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; distal axon [GO:0150034]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021]; ATP binding [GO:0005524]; gamma-tubulin binding [GO:0043015]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; associative learning [GO:0008306]; axonogenesis [GO:0007409]; centrosome duplication [GO:0051298]; DNA damage response [GO:0006974]; establishment of cell polarity [GO:0030010]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; neuron differentiation [GO:0030182]; neurotransmitter secretion [GO:0007269]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of neuron projection development [GO:0010975]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle clustering [GO:2000807]; response to UV [GO:0009411]; synaptic vesicle cycle [GO:0099504]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15150265}. Nucleus {ECO:0000269|PubMed:15150265}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Synapse {ECO:0000250|UniProtKB:B2DD29}. Presynaptic active zone {ECO:0000250|UniProtKB:B2DD29}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:B2DD29}. Note=Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity). {ECO:0000250}.
Q8TDD1	reviewed	DDX54_HUMAN	ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54)	DDX54	Homo sapiens (Human)	881	FUNCTION: Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}.		intracellular estrogen receptor signaling pathway [GO:0030520]; RNA metabolic process [GO:0016070]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nuclear estrogen receptor binding [GO:0030331]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nuclear estrogen receptor binding [GO:0030331]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714]; intracellular estrogen receptor signaling pathway [GO:0030520]; RNA metabolic process [GO:0016070]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Q8TDD2	reviewed	SP7_HUMAN	Transcription factor Sp7 (Zinc finger protein osterix)	SP7 OSX	Homo sapiens (Human)	431	FUNCTION: Transcriptional activator essential for osteoblast differentiation (PubMed:23457570). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). {ECO:0000250|UniProtKB:Q8VI67, ECO:0000269|PubMed:23457570}.	MISCELLANEOUS: [Isoform 2]: Generally expressed at much higher level than isoform 1. {ECO:0000305}.	cellular response to zinc ion starvation [GO:0034224]; cementum mineralization [GO:0071529]; diphosphate metabolic process [GO:0071344]; gene expression [GO:0010467]; hematopoietic stem cell differentiation [GO:0060218]; osteoblast differentiation [GO:0001649]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DEAD/H-box RNA helicase binding [GO:0017151]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DEAD/H-box RNA helicase binding [GO:0017151]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cellular response to zinc ion starvation [GO:0034224]; cementum mineralization [GO:0071529]; diphosphate metabolic process [GO:0071344]; gene expression [GO:0010467]; hematopoietic stem cell differentiation [GO:0060218]; osteoblast differentiation [GO:0001649]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VI67}.
Q8TDD5	reviewed	MCLN3_HUMAN	Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3)	MCOLN3	Homo sapiens (Human)	553	FUNCTION: Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151). {ECO:0000250|UniProtKB:Q8R4F0, ECO:0000269|PubMed:18369318, ECO:0000269|PubMed:19497048, ECO:0000269|PubMed:19522758, ECO:0000269|PubMed:19885840, ECO:0000269|PubMed:20378547, ECO:0000269|PubMed:21245134, ECO:0000269|PubMed:23469151, ECO:0000269|PubMed:29106414, ECO:0000305}.		calcium ion transmembrane transport [GO:0070588]; inner ear auditory receptor cell differentiation [GO:0042491]; locomotory behavior [GO:0007626]	autophagosome membrane [GO:0000421]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]; lipid binding [GO:0008289]; NAADP-sensitive calcium-release channel activity [GO:0072345]	autophagosome membrane [GO:0000421]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; lipid binding [GO:0008289]; NAADP-sensitive calcium-release channel activity [GO:0072345]; calcium ion transmembrane transport [GO:0070588]; inner ear auditory receptor cell differentiation [GO:0042491]; locomotory behavior [GO:0007626]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19522758, ECO:0000269|PubMed:29106414}; Multi-pass membrane protein {ECO:0000269|PubMed:29106414}. Early endosome membrane {ECO:0000269|PubMed:19497048, ECO:0000269|PubMed:19522758}; Multi-pass membrane protein {ECO:0000269|PubMed:29106414}. Late endosome membrane {ECO:0000269|PubMed:19497048, ECO:0000269|PubMed:19522758}; Multi-pass membrane protein {ECO:0000269|PubMed:29106414}. Lysosome membrane {ECO:0000269|PubMed:19522758}; Multi-pass membrane protein {ECO:0000269|PubMed:29106414}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:19522758}. Note=Recycles between the plasma membrane and intracellular compartments by a dynamin-dependent endocytic pathway (PubMed:19522758). Under normal conditions, only a very minor proportion is present at the cell membrane (PubMed:19522758). In the cochlea located at the base of stereocilia near the position of the ankle links (By similarity). {ECO:0000250|UniProtKB:Q8R4F0, ECO:0000269|PubMed:19522758}.
Q8TDF5	reviewed	NETO1_HUMAN	Neuropilin and tolloid-like protein 1 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1)	NETO1 BTCL1	Homo sapiens (Human)	533	FUNCTION: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity). {ECO:0000250}.		anterograde axonal transport of neurotransmitter receptor complex [GO:0140231]; memory [GO:0007613]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of excitatory postsynaptic potential [GO:2000463]; regulation of kainate selective glutamate receptor activity [GO:2000312]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; visual learning [GO:0008542]	axon cytoplasm [GO:1904115]; excitatory synapse [GO:0060076]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]	ionotropic glutamate receptor binding [GO:0035255]	axon cytoplasm [GO:1904115]; excitatory synapse [GO:0060076]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; ionotropic glutamate receptor binding [GO:0035255]; anterograde axonal transport of neurotransmitter receptor complex [GO:0140231]; memory [GO:0007613]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of excitatory postsynaptic potential [GO:2000463]; regulation of kainate selective glutamate receptor activity [GO:2000312]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000250}. Note=Component of the postsynaptic density (PSD) of excitatory synapses. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000305}.
Q8TDF6	reviewed	GRP4_HUMAN	RAS guanyl-releasing protein 4	RASGRP4	Homo sapiens (Human)	673	FUNCTION: Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation. {ECO:0000269|PubMed:11880369, ECO:0000269|PubMed:11956218, ECO:0000269|PubMed:12493770, ECO:0000269|PubMed:18024961}.	MISCELLANEOUS: [Isoform 2]: Probably inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Probably inactive. {ECO:0000305}.	activation of phospholipase C activity [GO:0007202]; cell population proliferation [GO:0008283]; myeloid cell differentiation [GO:0030099]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to extracellular stimulus [GO:0009991]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085]; activation of phospholipase C activity [GO:0007202]; cell population proliferation [GO:0008283]; myeloid cell differentiation [GO:0030099]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to extracellular stimulus [GO:0009991]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Recruited to membranes upon activation by DAG.
Q8TDG2	reviewed	ACTT1_HUMAN	Actin-related protein T1 (ARP-T1)	ACTRT1 ARPT1 HSD27	Homo sapiens (Human)	376	FUNCTION: Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. {ECO:0000269|PubMed:28869610}.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of smoothened signaling pathway [GO:0008589]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of smoothened signaling pathway [GO:0008589]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305|PubMed:28869610}. Cytoplasm {ECO:0000269|PubMed:28869610}. Nucleus {ECO:0000269|PubMed:28869610}. Note=Both detected in the nucleus and cytoplasm, localizes to the nucleus where it binds chromatin upon stimulation of the Hedgehog pathway. {ECO:0000269|PubMed:28869610}.
Q8TDG4	reviewed	HELQ_HUMAN	Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase)	HELQ HEL308	Homo sapiens (Human)	1101	FUNCTION: Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair (PubMed:11751861, PubMed:19995904, PubMed:21398521, PubMed:24005041, PubMed:24005565, PubMed:34316696, PubMed:34937945). Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (PubMed:34937945). Possesses both DNA unwinding and annealing activities (PubMed:34937945). Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA (PubMed:34937945). Efficiently unwinds substrates containing 3' overhangs or a D-loop (PubMed:21398521, PubMed:34937945). In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing (PubMed:34937945). Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences (PubMed:34316696, PubMed:34937945). {ECO:0000269|PubMed:11751861, ECO:0000269|PubMed:19995904, ECO:0000269|PubMed:21398521, ECO:0000269|PubMed:24005041, ECO:0000269|PubMed:24005565, ECO:0000269|PubMed:34316696, ECO:0000269|PubMed:34937945}.		DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]	nucleus [GO:0005634]; site of DNA damage [GO:0090734]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; single-stranded 3'-5' DNA helicase activity [GO:1990518]	nucleus [GO:0005634]; site of DNA damage [GO:0090734]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21398521}. Chromosome {ECO:0000269|PubMed:21398521, ECO:0000269|PubMed:34937945}. Note=Localizes to sites of DNA damage; localizes to damaged replication forks. {ECO:0000269|PubMed:21398521, ECO:0000269|PubMed:34937945}.
Q8TDH9	reviewed	BL1S5_HUMAN	Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC-1 subunit 5) (Protein Muted homolog)	BLOC1S5 MUTED	Homo sapiens (Human)	187	FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:32565547). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:32565547}.		anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosome to melanosome transport [GO:0035646]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; otolith morphogenesis [GO:0032474]; positive regulation of pigment cell differentiation [GO:0050942]; vesicle-mediated transport [GO:0016192]	axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; transport vesicle [GO:0030133]		axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; transport vesicle [GO:0030133]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosome to melanosome transport [GO:0035646]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; otolith morphogenesis [GO:0032474]; positive regulation of pigment cell differentiation [GO:0050942]; vesicle-mediated transport [GO:0016192]	
Q8TDI0	reviewed	CHD5_HUMAN	Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5)	CHD5 KIAA0444	Homo sapiens (Human)	1954	FUNCTION: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. {ECO:0000250|UniProtKB:A2A8L1, ECO:0000269|PubMed:23948251}.		cerebral cortex neuron differentiation [GO:0021895]; chromatin remodeling [GO:0006338]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; regulation of transcription by RNA polymerase II [GO:0006357]; sperm DNA condensation [GO:0035092]	chromatin [GO:0000785]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; H3K27me3 modified histone binding [GO:0061628]; helicase activity [GO:0004386]; histone binding [GO:0042393]; metal ion binding [GO:0046872]	chromatin [GO:0000785]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; H3K27me3 modified histone binding [GO:0061628]; helicase activity [GO:0004386]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; cerebral cortex neuron differentiation [GO:0021895]; chromatin remodeling [GO:0006338]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; regulation of transcription by RNA polymerase II [GO:0006357]; sperm DNA condensation [GO:0035092]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21931736, ECO:0000269|PubMed:23948251}. Chromosome {ECO:0000250|UniProtKB:A2A8L1}.
Q8TDI7	reviewed	TMC2_HUMAN	Transmembrane channel-like protein 2 (Transmembrane cochlear-expressed protein 2)	TMC2 C20orf145 UNQ907/PRO1928	Homo sapiens (Human)	906	FUNCTION: Probable ion channel required for the normal function of cochlear hair cells (PubMed:11850618). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity). {ECO:0000250|UniProtKB:E7FFT2, ECO:0000269|PubMed:11850618}.		detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of calcium ion transmembrane transport [GO:1903169]; vestibular reflex [GO:0060005]	plasma membrane [GO:0005886]; stereocilium tip [GO:0032426]	mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated calcium channel activity [GO:0005245]	plasma membrane [GO:0005886]; stereocilium tip [GO:0032426]; mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated calcium channel activity [GO:0005245]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of calcium ion transmembrane transport [GO:1903169]; vestibular reflex [GO:0060005]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E7FFT2}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the stereocilia of the cochlear hair cells. {ECO:0000250|UniProtKB:Q8R4P4}.
Q8TDI8	reviewed	TMC1_HUMAN	Transmembrane channel-like protein 1 (Transmembrane cochlear-expressed protein 1)	TMC1	Homo sapiens (Human)	760	FUNCTION: Probable ion channel required for the normal function of cochlear hair cells. {ECO:0000250|UniProtKB:Q8R4P5}.		auditory receptor cell development [GO:0060117]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of calcium ion transmembrane transport [GO:1903169]; vestibular reflex [GO:0060005]	external side of plasma membrane [GO:0009897]; stereocilium tip [GO:0032426]	mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated calcium channel activity [GO:0005245]	external side of plasma membrane [GO:0009897]; stereocilium tip [GO:0032426]; mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated calcium channel activity [GO:0005245]; auditory receptor cell development [GO:0060117]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of calcium ion transmembrane transport [GO:1903169]; vestibular reflex [GO:0060005]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8R4P5}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the stereocilia of the cochlear hair cells. {ECO:0000250|UniProtKB:Q8R4P5}.
Q8TDJ6	reviewed	DMXL2_HUMAN	DmX-like protein 2 (Rabconnectin-3)	DMXL2 KIAA0856	Homo sapiens (Human)	3036	FUNCTION: May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}.		vacuolar acidification [GO:0007035]	extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; RAVE complex [GO:0043291]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	small GTPase binding [GO:0031267]	extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; RAVE complex [GO:0043291]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; small GTPase binding [GO:0031267]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:11809763}; Peripheral membrane protein {ECO:0000269|PubMed:11809763}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle {ECO:0000250|UniProtKB:Q8BPN8}. Note=The external layer of the inferior boundary for the hypothalamus part of the human brain (the so called median eminence (ME)) displayed a punctate pattern of expression; expression also observed in the cell bodies lining the third ventricle, in the long processes extending from these cell bodies toward the external layer of the ME, in small clear vesicles, and in large dense core vesicles. {ECO:0000250|UniProtKB:Q8BPN8}.
Q8TDL5	reviewed	BPIB1_HUMAN	BPI fold-containing family B member 1 (Long palate, lung and nasal epithelium carcinoma-associated protein 1) (von Ebner minor salivary gland protein) (VEMSGP)	BPIFB1 C20orf114 LPLUNC1 UNQ706/PRO1357	Homo sapiens (Human)	484	FUNCTION: May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS. {ECO:0000269|PubMed:21900486}.		innate immune response in mucosa [GO:0002227]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	lipid binding [GO:0008289]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lipid binding [GO:0008289]; innate immune response in mucosa [GO:0002227]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q8TDM6	reviewed	DLG5_HUMAN	Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)	DLG5 KIAA0583 PDLG	Homo sapiens (Human)	1919	FUNCTION: Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}.		apical protein localization [GO:0045176]; cell-cell adhesion [GO:0098609]; epithelial to mesenchymal transition [GO:0001837]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; metanephric collecting duct development [GO:0072205]; midbrain development [GO:0030901]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of T cell proliferation [GO:0042130]; neuroepithelial cell differentiation [GO:0060563]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of hippo signaling [GO:0035332]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of synapse assembly [GO:0051965]; postsynapse organization [GO:0099173]; protein localization to adherens junction [GO:0071896]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]; zonula adherens assembly [GO:0045186]	adherens junction [GO:0005912]; cell junction [GO:0030054]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	beta-catenin binding [GO:0008013]; cytoskeletal protein binding [GO:0008092]; signaling receptor complex adaptor activity [GO:0030159]	adherens junction [GO:0005912]; cell junction [GO:0030054]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; beta-catenin binding [GO:0008013]; cytoskeletal protein binding [GO:0008092]; signaling receptor complex adaptor activity [GO:0030159]; apical protein localization [GO:0045176]; cell-cell adhesion [GO:0098609]; epithelial to mesenchymal transition [GO:0001837]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; metanephric collecting duct development [GO:0072205]; midbrain development [GO:0030901]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of T cell proliferation [GO:0042130]; neuroepithelial cell differentiation [GO:0060563]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of hippo signaling [GO:0035332]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of synapse assembly [GO:0051965]; postsynapse organization [GO:0099173]; protein localization to adherens junction [GO:0071896]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]; zonula adherens assembly [GO:0045186]	SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:12657639, ECO:0000269|PubMed:28169360}. Cell membrane {ECO:0000269|PubMed:12657639}; Peripheral membrane protein {ECO:0000269|PubMed:12657639}. Postsynaptic density {ECO:0000250|UniProtKB:E9Q9R9}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:E9Q9R9}. Note=Localized at sites of cell-cell contact.
Q8TDN1	reviewed	KCNG4_HUMAN	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4)	KCNG4 KCNG3	Homo sapiens (Human)	519	FUNCTION: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135). {ECO:0000269|PubMed:19074135}.		potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; transmembrane transporter binding [GO:0044325]	nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; transmembrane transporter binding [GO:0044325]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19074135}; Multi-pass membrane protein {ECO:0000305}. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Remains intracellular in the absence of KCNB1 (PubMed:19074135). {ECO:0000269|PubMed:19074135}.
Q8TDN2	reviewed	KCNV2_HUMAN	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2)	KCNV2	Homo sapiens (Human)	545	FUNCTION: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.		potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	voltage-gated potassium channel activity [GO:0005249]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.
Q8TDN4	reviewed	CABL1_HUMAN	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1)	CABLES1 CABLES	Homo sapiens (Human)	633	FUNCTION: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.		cell cycle [GO:0007049]; cell division [GO:0051301]; nervous system development [GO:0007399]; regulation of cell cycle [GO:0051726]	cytosol [GO:0005829]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleus [GO:0005634]; cell cycle [GO:0007049]; cell division [GO:0051301]; nervous system development [GO:0007399]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). {ECO:0000250}.
Q8TDN7	reviewed	ACER1_HUMAN	Alkaline ceramidase 1 (AlkCDase 1) (Alkaline CDase 1) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 3) (N-acylsphingosine amidohydrolase 3)	ACER1 ASAH3	Homo sapiens (Human)	264	FUNCTION: Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:17713573, PubMed:20207939, PubMed:20628055). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875). Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:17713573, PubMed:20207939). May also hydrolyze dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:17713573). {ECO:0000269|PubMed:17713573, ECO:0000269|PubMed:20207939, ECO:0000269|PubMed:20628055, ECO:0000303|PubMed:12783875}.		cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; ceramide catabolic process [GO:0046514]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; regulation of lipid metabolic process [GO:0019216]; response to alkaline pH [GO:0010446]; sebaceous gland development [GO:0048733]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid metabolic process [GO:0006665]; sphingosine biosynthetic process [GO:0046512]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	ceramidase activity [GO:0102121]; dihydroceramidase activity [GO:0071633]; metal ion binding [GO:0046872]; N-acylsphingosine amidohydrolase activity [GO:0017040]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ceramidase activity [GO:0102121]; dihydroceramidase activity [GO:0071633]; metal ion binding [GO:0046872]; N-acylsphingosine amidohydrolase activity [GO:0017040]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; ceramide catabolic process [GO:0046514]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; regulation of lipid metabolic process [GO:0019216]; response to alkaline pH [GO:0010446]; sebaceous gland development [GO:0048733]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid metabolic process [GO:0006665]; sphingosine biosynthetic process [GO:0046512]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17713573}; Multi-pass membrane protein {ECO:0000255}.
Q8TDP1	reviewed	RNH2C_HUMAN	Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C)	RNASEH2C AYP1	Homo sapiens (Human)	164	FUNCTION: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}.	MISCELLANEOUS: The T6 pseudogene located upstream of SRY on chromosome Y is derived from the transcript of this gene.	mismatch repair [GO:0006298]; RNA catabolic process [GO:0006401]	nucleus [GO:0005634]; ribonuclease H2 complex [GO:0032299]		nucleus [GO:0005634]; ribonuclease H2 complex [GO:0032299]; mismatch repair [GO:0006298]; RNA catabolic process [GO:0006401]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TDQ0	reviewed	HAVR2_HUMAN	Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)	HAVCR2 TIM3 TIMD3	Homo sapiens (Human)	301	FUNCTION: Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity). {ECO:0000250|UniProtKB:Q8VIM0, ECO:0000269|PubMed:11823861, ECO:0000269|PubMed:14556005, ECO:0000269|PubMed:16286920, ECO:0000269|PubMed:22323453, ECO:0000269|PubMed:23555261, ECO:0000269|PubMed:24838857, ECO:0000269|PubMed:26492563, ECO:0000269|PubMed:30374066, ECO:0000305|PubMed:24825777}.		adaptive immune response [GO:0002250]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation involved in immune response [GO:0002281]; maternal process involved in female pregnancy [GO:0060135]; natural killer cell tolerance induction [GO:0002519]; negative regulation of defense response to bacterium [GO:1900425]; negative regulation of gene expression [GO:0010629]; negative regulation of granulocyte colony-stimulating factor production [GO:0071656]; negative regulation of immunological synapse formation [GO:2000521]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-3 production [GO:0032712]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of myeloid dendritic cell activation [GO:0030886]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001189]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of chemokine production [GO:0032722]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of macrophage activation [GO:0043032]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of tolerance induction dependent upon immune response [GO:0002652]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162]	anchoring junction [GO:0070161]; cell surface [GO:0009986]; early endosome [GO:0005769]; immunological synapse [GO:0001772]; mediator complex [GO:0016592]	metal ion binding [GO:0046872]	anchoring junction [GO:0070161]; cell surface [GO:0009986]; early endosome [GO:0005769]; immunological synapse [GO:0001772]; mediator complex [GO:0016592]; metal ion binding [GO:0046872]; adaptive immune response [GO:0002250]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation involved in immune response [GO:0002281]; maternal process involved in female pregnancy [GO:0060135]; natural killer cell tolerance induction [GO:0002519]; negative regulation of defense response to bacterium [GO:1900425]; negative regulation of gene expression [GO:0010629]; negative regulation of granulocyte colony-stimulating factor production [GO:0071656]; negative regulation of immunological synapse formation [GO:2000521]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-3 production [GO:0032712]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of myeloid dendritic cell activation [GO:0030886]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001189]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of chemokine production [GO:0032722]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of macrophage activation [GO:0043032]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of tolerance induction dependent upon immune response [GO:0002652]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction {ECO:0000269|PubMed:24337741}. Cell membrane {ECO:0000269|PubMed:30374066}. Note=Localizes to the immunological synapse between CD8+ T-cells and target cells. {ECO:0000269|PubMed:24337741}.
Q8TDQ1	reviewed	CLM1_HUMAN	CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f)	CD300LF CD300F CLM1 IGSF13 IREM1 NKIR UNQ3105/PRO10111	Homo sapiens (Human)	290	FUNCTION: Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity). {ECO:0000250|UniProtKB:Q6SJQ7, ECO:0000269|PubMed:15549731, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:24035150}.		interleukin-13-mediated signaling pathway [GO:0035772]; negative regulation of apoptotic cell clearance [GO:2000426]; negative regulation of mast cell activation [GO:0033004]; negative regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034125]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	plasma membrane [GO:0005886]	ceramide binding [GO:0097001]; identical protein binding [GO:0042802]; interleukin-4 receptor binding [GO:0005136]; phosphatidylserine binding [GO:0001786]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; ceramide binding [GO:0097001]; identical protein binding [GO:0042802]; interleukin-4 receptor binding [GO:0005136]; phosphatidylserine binding [GO:0001786]; transmembrane signaling receptor activity [GO:0004888]; interleukin-13-mediated signaling pathway [GO:0035772]; negative regulation of apoptotic cell clearance [GO:2000426]; negative regulation of mast cell activation [GO:0033004]; negative regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034125]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8TDQ7	reviewed	GNPI2_HUMAN	Glucosamine-6-phosphate isomerase 2 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 2) (GNPDA 2) (GlcN6P deaminase 2) (Glucosamine-6-phosphate isomerase SB52)	GNPDA2 GNP2	Homo sapiens (Human)	276	FUNCTION: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. {ECO:0000269|PubMed:12616532, ECO:0000269|PubMed:26887390}.		carbohydrate metabolic process [GO:0005975]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; carbohydrate metabolic process [GO:0005975]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8TDR0	reviewed	MIPT3_HUMAN	TRAF3-interacting protein 1 (Interleukin-13 receptor alpha 1-binding protein 1) (Intraflagellar transport protein 54 homolog) (Microtubule-interacting protein associated with TRAF3) (MIP-T3)	TRAF3IP1 IFT54 MIPT3	Homo sapiens (Human)	691	FUNCTION: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:Q149C2, ECO:0000269|PubMed:10791955, ECO:0000269|PubMed:12812986, ECO:0000269|PubMed:12935900, ECO:0000269|PubMed:26487268}.		cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of defense response to virus [GO:0050687]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of type I interferon production [GO:0032480]; regulation of microtubule cytoskeleton organization [GO:0070507]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]	microtubule binding [GO:0008017]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]; microtubule binding [GO:0008017]; cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of defense response to virus [GO:0050687]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of type I interferon production [GO:0032480]; regulation of microtubule cytoskeleton organization [GO:0070507]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12935900}. Cell projection, cilium {ECO:0000269|PubMed:26487268}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q149C2}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q149C2}. Note=Microtubules (PubMed:12935900). In the cilium, it is observed at the ciliary base, ciliary transition zone and ciliary tip (PubMed:26487268). {ECO:0000269|PubMed:12935900, ECO:0000269|PubMed:26487268}.
Q8TDR2	reviewed	STK35_HUMAN	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase 1) (CLIK-1) (PDLIM1-interacting kinase 1) (Serine/threonine-protein kinase 35 L1)	STK35 CLIK1 PDIK1 STK35L1	Homo sapiens (Human)	534		MISCELLANEOUS: Association with PDLIM1 is controversial. {ECO:0000305|PubMed:11973348}.	autophagy [GO:0006914]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; protein serine kinase activity [GO:0106310]; autophagy [GO:0006914]	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Cytoplasm. Note=When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers (PubMed:11973348). However, PubMed:19756140 detected STK35 only in the nucleus, and the presence of PDLIM1 had no influence on its location. {ECO:0000269|PubMed:11973348}.
Q8TDR4	reviewed	TCP1L_HUMAN	T-complex protein 10A homolog 1 (T-complex protein 10A-1) (TCP10A-1) (TCP10-like)	TCP10L PRED77	Homo sapiens (Human)	215	FUNCTION: May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells. {ECO:0000269|PubMed:14586771, ECO:0000269|PubMed:24565846}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protein self-association [GO:0043621]; transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protein self-association [GO:0043621]; transcription corepressor activity [GO:0003714]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14586771, ECO:0000269|PubMed:15910542}.
Q8TDS4	reviewed	HCAR2_HUMAN	Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor)	HCAR2 GPR109A HCA2 HM74A NIACR1	Homo sapiens (Human)	363	FUNCTION: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. {ECO:0000269|PubMed:17932499}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of lipid catabolic process [GO:0050995]; neutrophil apoptotic process [GO:0001781]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of neutrophil apoptotic process [GO:0033031]	cell junction [GO:0030054]; plasma membrane [GO:0005886]	nicotinic acid receptor activity [GO:0070553]	cell junction [GO:0030054]; plasma membrane [GO:0005886]; nicotinic acid receptor activity [GO:0070553]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of lipid catabolic process [GO:0050995]; neutrophil apoptotic process [GO:0001781]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of neutrophil apoptotic process [GO:0033031]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17932499}; Multi-pass membrane protein {ECO:0000269|PubMed:17932499}.
Q8TDS5	reviewed	OXER1_HUMAN	Oxoeicosanoid receptor 1 (5-oxo-ETE G-protein coupled receptor) (G-protein coupled receptor 170) (G-protein coupled receptor R527) (G-protein coupled receptor TG1019)	OXER1 GPR170 TG1019	Homo sapiens (Human)	423	FUNCTION: Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins. {ECO:0000269|PubMed:12065583, ECO:0000269|PubMed:12606753}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding [GO:0050648]; 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding [GO:0050647]; 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding [GO:0050646]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding [GO:0050648]; 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding [GO:0050647]; 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding [GO:0050646]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8TDT2	reviewed	GP152_HUMAN	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5)	GPR152 PGR5	Homo sapiens (Human)	470	FUNCTION: Orphan receptor.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8TDU6	reviewed	GPBAR_HUMAN	G-protein coupled bile acid receptor 1 (G-protein coupled receptor GPCR19) (hGPCR19) (Membrane-type receptor for bile acids) (M-BAR) (hBG37) (BG37)	GPBAR1 TGR5	Homo sapiens (Human)	330	FUNCTION: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. {ECO:0000269|PubMed:12419312, ECO:0000269|PubMed:12524422}.		cell surface bile acid receptor signaling pathway [GO:0038184]; cellular response to bile acid [GO:1903413]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cholangiocyte proliferation [GO:1904056]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of bicellular tight junction assembly [GO:2000810]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	bile acid receptor activity [GO:0038181]; G protein-coupled bile acid receptor activity [GO:0038182]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; bile acid receptor activity [GO:0038181]; G protein-coupled bile acid receptor activity [GO:0038182]; cell surface bile acid receptor signaling pathway [GO:0038184]; cellular response to bile acid [GO:1903413]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cholangiocyte proliferation [GO:1904056]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of bicellular tight junction assembly [GO:2000810]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12524422}; Multi-pass membrane protein {ECO:0000269|PubMed:12524422}.
Q8TDU9	reviewed	RL3R2_HUMAN	Relaxin-3 receptor 2 (RLN3 receptor 2) (G-protein coupled receptor 100) (G-protein coupled receptor GPCR142) (Insulin-like peptide INSL5 receptor) (Relaxin family peptide receptor 4)	RXFP4 GPCR142 GPR100 RLN3R2	Homo sapiens (Human)	374	FUNCTION: High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation. {ECO:0000269|PubMed:14522967, ECO:0000269|PubMed:15525639}.		neuropeptide signaling pathway [GO:0007218]; positive regulation of feeding behavior [GO:2000253]	plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide signaling pathway [GO:0007218]; positive regulation of feeding behavior [GO:2000253]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8TDV0	reviewed	GP151_HUMAN	G-protein coupled receptor 151 (G-protein coupled receptor PGR7) (GPCR-2037) (Galanin receptor 4) (Galanin-receptor-like protein) (GalRL)	GPR151 GALR4 GALRL PGR7	Homo sapiens (Human)	419	FUNCTION: Proton-sensing G-protein coupled receptor. {ECO:0000269|PubMed:31119277}.		G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of immune response [GO:0050778]; response to acidic pH [GO:0010447]; response to ischemia [GO:0002931]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; neuropeptide receptor activity [GO:0008188]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; neuropeptide receptor activity [GO:0008188]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of immune response [GO:0050778]; response to acidic pH [GO:0010447]; response to ischemia [GO:0002931]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:31119277}; Multi-pass membrane protein {ECO:0000255}.
Q8TDW0	reviewed	LRC8C_HUMAN	Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C)	LRRC8C AD158 FAD158	Homo sapiens (Human)	803	FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:33171122}.		aspartate transmembrane transport [GO:0015810]; cellular response to osmotic stress [GO:0071470]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; fat cell differentiation [GO:0045444]; monoatomic anion transmembrane transport [GO:0098656]; protein hexamerization [GO:0034214]; signal transduction [GO:0007165]; taurine transport [GO:0015734]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]	volume-sensitive anion channel activity [GO:0005225]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]; volume-sensitive anion channel activity [GO:0005225]; aspartate transmembrane transport [GO:0015810]; cellular response to osmotic stress [GO:0071470]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; fat cell differentiation [GO:0045444]; monoatomic anion transmembrane transport [GO:0098656]; protein hexamerization [GO:0034214]; signal transduction [GO:0007165]; taurine transport [GO:0015734]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:28193731}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:24790029}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO:0000269|PubMed:24790029}.
Q8TDW5	reviewed	SYTL5_HUMAN	Synaptotagmin-like protein 5	SYTL5 SLP5	Homo sapiens (Human)	730	FUNCTION: May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.		exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]	exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; neurexin family protein binding [GO:0042043]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]	exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; neurexin family protein binding [GO:0042043]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q8TDW7	reviewed	FAT3_HUMAN	Protocadherin Fat 3 (hFat3) (Cadherin family member 15) (FAT tumor suppressor homolog 3)	FAT3 CDHF15 KIAA1989	Homo sapiens (Human)	4557	FUNCTION: May play a role in the interactions between neurites derived from specific subsets of neurons during development. {ECO:0000250}.		cell morphogenesis involved in differentiation [GO:0000904]; cell-cell adhesion [GO:0098609]; dendrite development [GO:0016358]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; interneuron migration [GO:1904936]; negative regulation of dendrite development [GO:2000171]; retina layer formation [GO:0010842]	dendrite [GO:0030425]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell morphogenesis involved in differentiation [GO:0000904]; cell-cell adhesion [GO:0098609]; dendrite development [GO:0016358]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; interneuron migration [GO:1904936]; negative regulation of dendrite development [GO:2000171]; retina layer formation [GO:0010842]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8TDX5	reviewed	ACMSD_HUMAN	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase)	ACMSD	Homo sapiens (Human)	336	FUNCTION: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. {ECO:0000269|PubMed:19843166}.		negative regulation of quinolinate biosynthetic process [GO:1904985]; picolinic acid biosynthetic process [GO:1905004]; regulation of 'de novo' NAD biosynthetic process from tryptophan [GO:1905012]; secondary metabolic process [GO:0019748]; tryptophan catabolic process [GO:0006569]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	aminocarboxymuconate-semialdehyde decarboxylase activity [GO:0001760]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; aminocarboxymuconate-semialdehyde decarboxylase activity [GO:0001760]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270]; negative regulation of quinolinate biosynthetic process [GO:1904985]; picolinic acid biosynthetic process [GO:1905004]; regulation of 'de novo' NAD biosynthetic process from tryptophan [GO:1905012]; secondary metabolic process [GO:0019748]; tryptophan catabolic process [GO:0006569]	
Q8TDX6	reviewed	CGAT1_HUMAN	Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CsGalNAcT-1) (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1) (Beta4GalNAcT-1)	CSGALNACT1 CHGN GALNACT1 UNQ656/PRO1287	Homo sapiens (Human)	532	FUNCTION: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758, PubMed:31705726). Moreover, is involved in the metabolism of aggrecan (By similarity). {ECO:0000250|UniProtKB:Q8BJQ9, ECO:0000269|PubMed:11788602, ECO:0000269|PubMed:12163485, ECO:0000269|PubMed:12446672, ECO:0000269|PubMed:17145758, ECO:0000269|PubMed:21160489, ECO:0000269|PubMed:27599773, ECO:0000269|PubMed:31705726}.		cartilage development [GO:0051216]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050653]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; proteoglycan biosynthetic process [GO:0030166]; UDP-glucuronate metabolic process [GO:0046398]; UDP-N-acetylgalactosamine metabolic process [GO:0019276]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	acetylgalactosaminyltransferase activity [GO:0008376]; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; glucuronosyltransferase activity [GO:0015020]; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047237]; metal ion binding [GO:0046872]; peptidoglycan glycosyltransferase activity [GO:0008955]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; acetylgalactosaminyltransferase activity [GO:0008376]; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; glucuronosyltransferase activity [GO:0015020]; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047237]; metal ion binding [GO:0046872]; peptidoglycan glycosyltransferase activity [GO:0008955]; cartilage development [GO:0051216]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050653]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; proteoglycan biosynthetic process [GO:0030166]; UDP-glucuronate metabolic process [GO:0046398]; UDP-N-acetylgalactosamine metabolic process [GO:0019276]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:11788602}; Single-pass type II membrane protein {ECO:0000305|PubMed:11788602}.
Q8TDX7	reviewed	NEK7_HUMAN	Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)	NEK7	Homo sapiens (Human)	302	FUNCTION: Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:31409757, PubMed:19941817). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596, PubMed:31409757, PubMed:19941817, PubMed:26522158). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (PubMed:26642356, PubMed:36442502). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (PubMed:26642356, PubMed:31189953, PubMed:36442502). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (PubMed:26642356, PubMed:31189953). {ECO:0000250|UniProtKB:D3ZBE5, ECO:0000269|PubMed:17101132, ECO:0000269|PubMed:17586473, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158, ECO:0000269|PubMed:26642356, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:31409757, ECO:0000269|PubMed:36442502}.		cellular response to potassium ion [GO:0035865]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle [GO:0007346]; spindle assembly [GO:0051225]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cellular response to potassium ion [GO:0035865]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle [GO:0007346]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ES74}. Cytoplasm {ECO:0000269|PubMed:17586473}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19414596}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17101132, ECO:0000269|PubMed:17586473}. Note=Present at centrosome throughout the cell cycle (PubMed:17586473). Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (PubMed:17586473). Interaction with ANKS3 prevents its translocation to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9ES74, ECO:0000269|PubMed:17586473}.
Q8TDX9	reviewed	PK1L1_HUMAN	Polycystin-1-like protein 1 (Polycystin-1L1) (PC1-like 1 protein) (Polycystic kidney disease protein 1-like 1)	PKD1L1 UNQ5785/PRO19563	Homo sapiens (Human)	2849	FUNCTION: Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. {ECO:0000269|PubMed:24336289}.		cell-cell adhesion [GO:0098609]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; left/right axis specification [GO:0070986]	calcium channel complex [GO:0034704]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; membrane [GO:0016020]; non-motile cilium [GO:0097730]	calcium channel activity [GO:0005262]	calcium channel complex [GO:0034704]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; calcium channel activity [GO:0005262]; cell-cell adhesion [GO:0098609]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; left/right axis specification [GO:0070986]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:24336289}; Multi-pass membrane protein {ECO:0000269|PubMed:24336289}.
Q8TDY2	reviewed	RBCC1_HUMAN	RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200)	RB1CC1 KIAA0203 RBICC	Homo sapiens (Human)	1594	FUNCTION: Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}.	MISCELLANEOUS: Probably involved in the tumorigenesis of breast cancer. RB1CC1 is frequently mutated in breast cancer and shows characteristics of a classical tumor suppressor gene.	autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; autophagy of peroxisome [GO:0030242]; cell cycle [GO:0007049]; extrinsic apoptotic signaling pathway [GO:0097191]; glycophagy [GO:0061723]; heart development [GO:0007507]; liver development [GO:0001889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; positive regulation of cell size [GO:0045793]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; regulation of protein lipidation [GO:1903059]; reticulophagy [GO:0061709]	Atg1/ULK1 kinase complex [GO:1990316]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lysosome [GO:0005764]; nuclear membrane [GO:0031965]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]	molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein-membrane adaptor activity [GO:0043495]	Atg1/ULK1 kinase complex [GO:1990316]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lysosome [GO:0005764]; nuclear membrane [GO:0031965]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein-membrane adaptor activity [GO:0043495]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; autophagy of peroxisome [GO:0030242]; cell cycle [GO:0007049]; extrinsic apoptotic signaling pathway [GO:0097191]; glycophagy [GO:0061723]; heart development [GO:0007507]; liver development [GO:0001889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; positive regulation of cell size [GO:0045793]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; regulation of protein lipidation [GO:1903059]; reticulophagy [GO:0061709]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11850849}. Cytoplasm {ECO:0000269|PubMed:10769033}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ESK9}. Preautophagosomal structure {ECO:0000269|PubMed:28561066}. Lysosome {ECO:0000269|PubMed:28561066}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:28890335}.
Q8TDY4	reviewed	ASAP3_HUMAN	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1)	ASAP3 DDEFL1 UPLC1	Homo sapiens (Human)	903	FUNCTION: Promotes cell proliferation. {ECO:0000269|PubMed:14654939}.		cell migration [GO:0016477]; positive regulation of GTPase activity [GO:0043547]; regulation of stress fiber assembly [GO:0051492]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; ruffle [GO:0001726]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; ruffle [GO:0001726]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; cell migration [GO:0016477]; positive regulation of GTPase activity [GO:0043547]; regulation of stress fiber assembly [GO:0051492]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14654939}.
Q8TDZ2	reviewed	MICA1_HUMAN	[F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains)	MICAL1 MICAL NICAL	Homo sapiens (Human)	1067	FUNCTION: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023, PubMed:29343822). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (PubMed:32344433). {ECO:0000250|UniProtKB:Q8VDP3, ECO:0000269|PubMed:18305261, ECO:0000269|PubMed:21864500, ECO:0000269|PubMed:26845023, ECO:0000269|PubMed:28230050, ECO:0000269|PubMed:29343822, ECO:0000269|PubMed:32344433, ECO:0000305|PubMed:27552051}.		actin filament bundle assembly [GO:0051017]; actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; regulation of regulated secretory pathway [GO:1903305]; signal transduction [GO:0007165]; sulfur oxidation [GO:0019417]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; hippocampal mossy fiber expansion [GO:1990026]; intercellular bridge [GO:0045171]; intermediate filament [GO:0005882]; midbody [GO:0030496]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADPH oxidase H202-forming activity [GO:0106294]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; hippocampal mossy fiber expansion [GO:1990026]; intercellular bridge [GO:0045171]; intermediate filament [GO:0005882]; midbody [GO:0030496]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADPH oxidase H202-forming activity [GO:0106294]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]; actin filament bundle assembly [GO:0051017]; actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; regulation of regulated secretory pathway [GO:1903305]; signal transduction [GO:0007165]; sulfur oxidation [GO:0019417]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32344433}. Cytoplasm, cytoskeleton. Endosome membrane {ECO:0000269|PubMed:32344433}. Midbody {ECO:0000269|PubMed:28230050}. Note=Accumulates transiently at the abscission site before abscission occurs. Colocalized with GRAF1/ARHGAP26 and GRAF2/ARHGAP10, RAB8A, RAB8B and RAB10 on endosomal tubules (PubMed:32344433). {ECO:0000269|PubMed:28230050, ECO:0000269|PubMed:32344433}.
Q8TE02	reviewed	ELP5_HUMAN	Elongator complex protein 5 (Dermal papilla-derived protein 6) (S-phase 2 protein)	ELP5 C17orf81 DERP6 HSPC002 MSTP071	Homo sapiens (Human)	316	FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity). {ECO:0000250|UniProtKB:Q99L85, ECO:0000303|PubMed:29332244}.		positive regulation of cell migration [GO:0030335]; regulation of translation [GO:0006417]; tRNA modification [GO:0006400]; tRNA wobble uridine modification [GO:0002098]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; positive regulation of cell migration [GO:0030335]; regulation of translation [GO:0006417]; tRNA modification [GO:0006400]; tRNA wobble uridine modification [GO:0002098]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22854966}. Cytoplasm {ECO:0000269|PubMed:16850183, ECO:0000269|PubMed:22854966}.
Q8TE04	reviewed	PANK1_HUMAN	Pantothenate kinase 1 (hPanK) (hPanK1) (EC 2.7.1.33) (Pantothenic acid kinase 1)	PANK1 PANK	Homo sapiens (Human)	598	FUNCTION: [Isoform 1]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:14523052, ECO:0000269|PubMed:17631502}.		coenzyme A biosynthetic process [GO:0015937]; phosphorylation [GO:0016310]	clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; recycling endosome [GO:0055037]	acetyl-CoA binding [GO:1905502]; ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]; protein homodimerization activity [GO:0042803]	clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; recycling endosome [GO:0055037]; acetyl-CoA binding [GO:1905502]; ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]; protein homodimerization activity [GO:0042803]; coenzyme A biosynthetic process [GO:0015937]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14523052}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:23152917}. Nucleus, nucleolus {ECO:0000269|PubMed:23152917}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:23152917}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:23152917}. Recycling endosome {ECO:0000269|PubMed:23152917}.
Q8TE12	reviewed	LMX1A_HUMAN	LIM homeobox transcription factor 1-alpha (LIM/homeobox protein 1.1) (LMX-1.1) (LIM/homeobox protein LMX1A)	LMX1A	Homo sapiens (Human)	382	FUNCTION: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; central nervous system neuron differentiation [GO:0021953]; cerebellum development [GO:0021549]; dentate gyrus development [GO:0021542]; dopaminergic neuron differentiation [GO:0071542]; locomotory behavior [GO:0007626]; memory [GO:0007613]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of neuron differentiation [GO:0045665]; neuron differentiation [GO:0030182]; olfactory behavior [GO:0042048]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell growth [GO:0001558]; regulation of transcription by RNA polymerase II [GO:0006357]; synapse organization [GO:0050808]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; axon guidance [GO:0007411]; central nervous system neuron differentiation [GO:0021953]; cerebellum development [GO:0021549]; dentate gyrus development [GO:0021542]; dopaminergic neuron differentiation [GO:0071542]; locomotory behavior [GO:0007626]; memory [GO:0007613]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of neuron differentiation [GO:0045665]; neuron differentiation [GO:0030182]; olfactory behavior [GO:0042048]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell growth [GO:0001558]; regulation of transcription by RNA polymerase II [GO:0006357]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q8TE23	reviewed	TS1R2_HUMAN	Taste receptor type 1 member 2 (G-protein coupled receptor 71) (Sweet taste receptor T1R2)	TAS1R2 GPR71 T1R2 TR2	Homo sapiens (Human)	839	FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.		detection of chemical stimulus involved in sensory perception of sweet taste [GO:0001582]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytokinesis [GO:0032467]; sensory perception of sweet taste [GO:0050916]	membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; sweet taste receptor complex [GO:1903767]	G protein-coupled receptor activity [GO:0004930]; sweet taste receptor activity [GO:0033041]; taste receptor activity [GO:0008527]	membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; sweet taste receptor complex [GO:1903767]; G protein-coupled receptor activity [GO:0004930]; sweet taste receptor activity [GO:0033041]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of sweet taste [GO:0001582]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytokinesis [GO:0032467]; sensory perception of sweet taste [GO:0050916]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8TE49	reviewed	OTU7A_HUMAN	OTU domain-containing protein 7A (EC 3.4.19.12) (Zinc finger protein Cezanne 2)	OTUD7A C15orf16 CEZANNE2 OTUD7	Homo sapiens (Human)	926	FUNCTION: Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains. {ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:23827681}.		protein K11-linked deubiquitination [GO:0035871]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; DNA binding [GO:0003677]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; DNA binding [GO:0003677]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270]; protein K11-linked deubiquitination [GO:0035871]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q8TE54	reviewed	S26A7_HUMAN	Anion exchange transporter (Solute carrier family 26 member 7)	SLC26A7 SUT2	Homo sapiens (Human)	656	FUNCTION: Acts as an anion channel mediating the transport of chloride, sulfate and oxalate ions (PubMed:11834742). Mediates the transport of bromide, iodide, nitrate, gluconate, thiocyanate and bicarbonate ions (By similarity). Its permeability towards bicarbonate is weak and increases when pH is above 7 (By similarity). Mediates thiocyanate transport in retinal pigment epithelium cells (By similarity). Mediates iodide transport in the thyroid gland, playing an important role in the synthesis of thyroid hormones and the maintenance of thyroid function (PubMed:31372509). Although it is an anion channel, according to PubMed:12736153 and PubMed:32119864 it has been shown to exhibit chloride-bicarbonate exchanger activity. {ECO:0000250|UniProtKB:Q8R2Z3, ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:12736153, ECO:0000269|PubMed:31372509, ECO:0000269|PubMed:32119864}.		bicarbonate transport [GO:0015701]; chloride transport [GO:0006821]; gastric acid secretion [GO:0001696]; gluconate transmembrane transport [GO:0035429]; iodide transport [GO:0015705]; monoatomic ion transport [GO:0006811]; nitrate transmembrane transport [GO:0015706]; oxalate transport [GO:0019532]; sulfate transport [GO:0008272]; thyroid hormone generation [GO:0006590]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; endosome [GO:0005768]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; endosome [GO:0005768]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116]; bicarbonate transport [GO:0015701]; chloride transport [GO:0006821]; gastric acid secretion [GO:0001696]; gluconate transmembrane transport [GO:0035429]; iodide transport [GO:0015705]; monoatomic ion transport [GO:0006811]; nitrate transmembrane transport [GO:0015706]; oxalate transport [GO:0019532]; sulfate transport [GO:0008272]; thyroid hormone generation [GO:0006590]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:16524946, ECO:0000269|PubMed:30333321, ECO:0000269|PubMed:32119864}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:16524946}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:31372509}; Multi-pass membrane protein {ECO:0000255}. Lateral cell membrane {ECO:0000269|PubMed:31372509}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO:0000269|PubMed:16524946}.
Q8TE56	reviewed	ATS17_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAM-TS 17) (ADAM-TS17) (ADAMTS-17) (EC 3.4.24.-)	ADAMTS17	Homo sapiens (Human)	1095			extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q8TE57	reviewed	ATS16_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-)	ADAMTS16 KIAA2029	Homo sapiens (Human)	1224			branching involved in ureteric bud morphogenesis [GO:0001658]; extracellular matrix organization [GO:0030198]; male gamete generation [GO:0048232]; proteolysis [GO:0006508]; regulation of cilium assembly [GO:1902017]; regulation of systemic arterial blood pressure [GO:0003073]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; branching involved in ureteric bud morphogenesis [GO:0001658]; extracellular matrix organization [GO:0030198]; male gamete generation [GO:0048232]; proteolysis [GO:0006508]; regulation of cilium assembly [GO:1902017]; regulation of systemic arterial blood pressure [GO:0003073]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q8TE58	reviewed	ATS15_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAM-TS 15) (ADAM-TS15) (ADAMTS-15) (EC 3.4.24.-)	ADAMTS15	Homo sapiens (Human)	950	FUNCTION: Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration. {ECO:0000250|UniProtKB:P59384}.		extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; myoblast fusion [GO:0007520]; proteolysis [GO:0006508]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	endopeptidase activity [GO:0004175]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; endopeptidase activity [GO:0004175]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; myoblast fusion [GO:0007520]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P59384}. Cell surface {ECO:0000250|UniProtKB:P59384}.
Q8TE59	reviewed	ATS19_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAM-TS 19) (ADAM-TS19) (ADAMTS-19) (EC 3.4.24.-)	ADAMTS19	Homo sapiens (Human)	1207			extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q8TE60	reviewed	ATS18_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) (EC 3.4.24.-)	ADAMTS18 ADAMTS21	Homo sapiens (Human)	1221			extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; negative regulation of platelet aggregation [GO:0090331]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; negative regulation of platelet aggregation [GO:0090331]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q8TE67	reviewed	ES8L3_HUMAN	Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3)	EPS8L3 EPS8R3	Homo sapiens (Human)	593			positive regulation of ruffle assembly [GO:1900029]; regulation of hair cycle [GO:0042634]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	actin binding [GO:0003779]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; actin binding [GO:0003779]; positive regulation of ruffle assembly [GO:1900029]; regulation of hair cycle [GO:0042634]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14565974}.
Q8TE68	reviewed	ES8L1_HUMAN	Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1)	EPS8L1 DRC3 EPS8R1 PP10566	Homo sapiens (Human)	723	FUNCTION: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}.		positive regulation of ruffle assembly [GO:1900029]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]	actin binding [GO:0003779]; cadherin binding [GO:0045296]; T cell receptor binding [GO:0042608]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; T cell receptor binding [GO:0042608]; positive regulation of ruffle assembly [GO:1900029]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14565974}.
Q8TE73	reviewed	DYH5_HUMAN	Dynein axonemal heavy chain 5 (Axonemal beta dynein heavy chain 5) (Ciliary dynein heavy chain 5)	DNAH5 DNAHC5 HL1 KIAA1603	Homo sapiens (Human)	4624	FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.		cilium assembly [GO:0060271]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; heart development [GO:0007507]; lateral ventricle development [GO:0021670]; outer dynein arm assembly [GO:0036158]	9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]	9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; heart development [GO:0007507]; lateral ventricle development [GO:0021670]; outer dynein arm assembly [GO:0036158]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:31178125}.
Q8TE76	reviewed	MORC4_HUMAN	MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled-coil domain protein 2) (Zinc finger CW-type domain protein 4)	MORC4 ZCW4 ZCWCC2	Homo sapiens (Human)	937	FUNCTION: Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:26933034}.			nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP hydrolysis activity [GO:0016887]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP hydrolysis activity [GO:0016887]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:17608765}.
Q8TE77	reviewed	SSH3_HUMAN	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L)	SSH3 SSH3L	Homo sapiens (Human)	659	FUNCTION: Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). {ECO:0000250}.	MISCELLANEOUS: Tyrosine phosphatase activity has not been demonstrated for this protein to date.	actin cytoskeleton organization [GO:0030036]; dephosphorylation [GO:0016311]; negative regulation of actin filament polymerization [GO:0030837]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]	actin binding [GO:0003779]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; actin binding [GO:0003779]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; actin cytoskeleton organization [GO:0030036]; dephosphorylation [GO:0016311]; negative regulation of actin filament polymerization [GO:0030837]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}.
Q8TE85	reviewed	GRHL3_HUMAN	Grainyhead-like protein 3 homolog (Sister of mammalian grainyhead) (Transcription factor CP2-like 4)	GRHL3 SOM TFCP2L4	Homo sapiens (Human)	626	FUNCTION: Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122). {ECO:0000250|UniProtKB:Q5FWH3, ECO:0000269|PubMed:12549979, ECO:0000269|PubMed:21081122, ECO:0000269|PubMed:24360809, ECO:0000269|PubMed:25347468}.	MISCELLANEOUS: GRHL genes (GRHL1, GRHL2 and GRHL3) show a paradoxical lack of redundancy despite their extensive sequence identity in the DNA-binding and protein dimerization domains and the fact that the core consensus DNA binding sites are identical. They have related, but remarkably different functions during embryogenesis because of their differential spatiotemporal expression patterns during development. {ECO:0000250|UniProtKB:Q5FWH3}.	central nervous system development [GO:0007417]; cochlea morphogenesis [GO:0090103]; ectoderm development [GO:0007398]; epidermis development [GO:0008544]; establishment of planar polarity [GO:0001736]; establishment of skin barrier [GO:0061436]; eyelid development in camera-type eye [GO:0061029]; neural tube closure [GO:0001843]; pattern specification process [GO:0007389]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]; wound healing [GO:0042060]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; central nervous system development [GO:0007417]; cochlea morphogenesis [GO:0090103]; ectoderm development [GO:0007398]; epidermis development [GO:0008544]; establishment of planar polarity [GO:0001736]; establishment of skin barrier [GO:0061436]; eyelid development in camera-type eye [GO:0061029]; neural tube closure [GO:0001843]; pattern specification process [GO:0007389]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21081122}.
Q8TE99	reviewed	PXYP1_HUMAN	2-phosphoxylose phosphatase 1 (EC 3.1.3.-) (Acid phosphatase-like protein 2) (Xylosyl phosphatase) (epididymis luminal protein 124)	PXYLP1 ACPL2 HEL124 XYLP UNQ370/PRO706	Homo sapiens (Human)	480	FUNCTION: Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. {ECO:0000269|PubMed:24425863}.		chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; dephosphorylation [GO:0016311]; glycosaminoglycan biosynthetic process [GO:0006024]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	phosphatase activity [GO:0016791]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; phosphatase activity [GO:0016791]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; dephosphorylation [GO:0016311]; glycosaminoglycan biosynthetic process [GO:0006024]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:24425863}; Single-pass type II membrane protein {ECO:0000255}. Note=Colocalizes to Golgi apparatus in a B3GAT3-dependent manner. {ECO:0000269|PubMed:24425863}.
Q8TEA1	reviewed	NSUN6_HUMAN	tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 (EC 2.1.1.-) (NOL1/NOP2/Sun and PUA domain-containing protein 1) (NOL1/NOP2/Sun domain family member 6)	NSUN6 NOPD1	Homo sapiens (Human)	469	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA) (PubMed:26160102, PubMed:27703015, PubMed:28531330). In vitro also methylates tRNA(Thr)(AGT) (PubMed:27703015, PubMed:26160102). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates (PubMed:26160102, PubMed:27703015). {ECO:0000269|PubMed:26160102, ECO:0000269|PubMed:27703015, ECO:0000269|PubMed:28531330}.		RNA methylation [GO:0001510]; tRNA C5-cytosine methylation [GO:0002946]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	tRNA (cytosine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; tRNA (cytosine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]; RNA methylation [GO:0001510]; tRNA C5-cytosine methylation [GO:0002946]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26160102}.
Q8TEA7	reviewed	TBCK_HUMAN	TBC domain-containing protein kinase-like protein	TBCK TBCKL HSPC302	Homo sapiens (Human)	893	FUNCTION: Involved in the modulation of mTOR signaling and expression of mTOR complex components (PubMed:27040691, PubMed:23977024). Involved in the regulation of cell proliferation and growth (PubMed:23977024, PubMed:24576458). Involved in the control of actin-cytoskeleton organization (PubMed:23977024). {ECO:0000269|PubMed:23977024, ECO:0000269|PubMed:24576458, ECO:0000269|PubMed:27040691}.		actin cytoskeleton organization [GO:0030036]; cell population proliferation [GO:0008283]; regulation of TOR signaling [GO:0032006]	cytoplasm [GO:0005737]; midbody [GO:0030496]; mitotic spindle [GO:0072686]	ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; protein kinase activity [GO:0004672]	cytoplasm [GO:0005737]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; protein kinase activity [GO:0004672]; actin cytoskeleton organization [GO:0030036]; cell population proliferation [GO:0008283]; regulation of TOR signaling [GO:0032006]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23977024, ECO:0000269|PubMed:24576458}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:24576458}. Midbody {ECO:0000269|PubMed:24576458}. Note=Mainly localized in the cytoplasm during interphase. During metaphase, TBCK accumulates at the mitotic spindle. At the end of mitosis, it is detected at the midbody. {ECO:0000269|PubMed:24576458}.
Q8TEA8	reviewed	DTD1_HUMAN	D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related)	DTD1 C20orf88 DUEB HARS2	Homo sapiens (Human)	209	FUNCTION: Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}.		DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; tRNA metabolic process [GO:0006399]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	D-tyrosyl-tRNA(Tyr) deacylase activity [GO:0051500]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; D-tyrosyl-tRNA(Tyr) deacylase activity [GO:0051500]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; tRNA binding [GO:0000049]; DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; tRNA metabolic process [GO:0006399]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}. Cytoplasm {ECO:0000250|UniProtKB:Q8IIS0}. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements (PubMed:20065034).
Q8TEB1	reviewed	DCA11_HUMAN	DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23)	DCAF11 WDR23 GL014 PRO2389	Homo sapiens (Human)	546	FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	
Q8TEB7	reviewed	RN128_HUMAN	E3 ubiquitin-protein ligase RNF128 (EC 2.3.2.27) (Gene related to anergy in lymphocytes protein) (GRAIL) (RING finger protein 128) (RING-type E3 ubiquitin transferase RNF128)	RNF128	Homo sapiens (Human)	428	FUNCTION: E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. {ECO:0000269|PubMed:12705856, ECO:0000269|PubMed:22016387}.		negative regulation of cytokine production [GO:0001818]; positive regulation of protein catabolic process in the vacuole [GO:1904352]; protein localization to lysosome [GO:0061462]; protein ubiquitination [GO:0016567]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of cytokine production [GO:0001818]; positive regulation of protein catabolic process in the vacuole [GO:1904352]; protein localization to lysosome [GO:0061462]; protein ubiquitination [GO:0016567]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12705856, ECO:0000269|PubMed:22016387}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). {ECO:0000250}.
Q8TEB9	reviewed	RHBL4_HUMAN	Rhomboid-related protein 4 (RRP4) (EC 3.4.21.105) (Rhomboid domain-containing protein 1) (Rhomboid-like protein 4)	RHBDD1 RHBDL4 HSD-50 HSD50	Homo sapiens (Human)	315	FUNCTION: Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia. {ECO:0000269|PubMed:18953687, ECO:0000269|PubMed:22624035}.		apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; ERAD pathway [GO:0036503]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; membrane protein proteolysis involved in retrograde protein transport, ER to cytosol [GO:1904211]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein processing [GO:0010954]; positive regulation of secretion [GO:0051047]; post-translational protein modification [GO:0043687]; spermatid differentiation [GO:0048515]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; mitochondrial membrane [GO:0031966]	endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; mitochondrial membrane [GO:0031966]; endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252]; apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; ERAD pathway [GO:0036503]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; membrane protein proteolysis involved in retrograde protein transport, ER to cytosol [GO:1904211]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein processing [GO:0010954]; positive regulation of secretion [GO:0051047]; post-translational protein modification [GO:0043687]; spermatid differentiation [GO:0048515]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22795130}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:18953687}; Multi-pass membrane protein {ECO:0000255}.
Q8TEC5	reviewed	SH3R2_HUMAN	E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (Heart protein phosphatase 1-binding protein) (HEPP1) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2)	SH3RF2 POSH3 POSHER PPP1R39 RNF158	Homo sapiens (Human)	729	FUNCTION: Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623). {ECO:0000269|PubMed:19389623, ECO:0000269|PubMed:19945436, ECO:0000269|PubMed:22128169, ECO:0000269|PubMed:24130170}.		negative regulation of apoptotic process [GO:0043066]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of cell migration [GO:0030335]; positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; ubiquitin protein ligase activity [GO:0061630]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of cell migration [GO:0030335]; positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24130170}.
Q8TED0	reviewed	UTP15_HUMAN	U3 small nucleolar RNA-associated protein 15 homolog	UTP15	Homo sapiens (Human)	518	FUNCTION: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}.		positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:24219289, ECO:0000269|PubMed:34516797}. Note=Found predominantly at the fibrillar center. {ECO:0000269|PubMed:24219289}.
Q8TED1	reviewed	GPX8_HUMAN	Probable glutathione peroxidase 8 (GPx-8) (GSHPx-8) (EC 1.11.1.9)	GPX8 UNQ847/PRO1785	Homo sapiens (Human)	209			cellular response to oxidative stress [GO:0034599]	endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]	glutathione peroxidase activity [GO:0004602]; peroxidase activity [GO:0004601]	endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]; glutathione peroxidase activity [GO:0004602]; peroxidase activity [GO:0004601]; cellular response to oxidative stress [GO:0034599]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8TED4	reviewed	G6PT3_HUMAN	Glucose-6-phosphate exchanger SLC37A2 (Solute carrier family 37 member 2)	SLC37A2	Homo sapiens (Human)	501	FUNCTION: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. {ECO:0000269|PubMed:21949678}.		carbohydrate transport [GO:0008643]; glucose-6-phosphate transport [GO:0015760]; phosphate ion transmembrane transport [GO:0035435]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]	glucose 6-phosphate:inorganic phosphate antiporter activity [GO:0061513]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; glucose 6-phosphate:inorganic phosphate antiporter activity [GO:0061513]; carbohydrate transport [GO:0008643]; glucose-6-phosphate transport [GO:0015760]; phosphate ion transmembrane transport [GO:0035435]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21949678}; Multi-pass membrane protein {ECO:0000255}.
Q8TED9	reviewed	AF1L1_HUMAN	Actin filament-associated protein 1-like 1 (AFAP1-like protein 1)	AFAP1L1	Homo sapiens (Human)	768	FUNCTION: May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}.			anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytosol [GO:0005829]; podosome [GO:0002102]	SH3 domain binding [GO:0017124]	anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytosol [GO:0005829]; podosome [GO:0002102]; SH3 domain binding [GO:0017124]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21333378}. Cell projection, podosome {ECO:0000269|PubMed:21333378}. Cell projection, invadopodium {ECO:0000269|PubMed:21333378}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:21333378}.
Q8TEH3	reviewed	DEN1A_HUMAN	DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A)	DENND1A FAM31A KIAA1608	Homo sapiens (Human)	1009	FUNCTION: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.		endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of Rab protein signal transduction [GO:0032483]	cell projection [GO:0042995]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; presynaptic membrane [GO:0042734]	guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]	cell projection [GO:0042995]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; presynaptic membrane [GO:0042734]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of Rab protein signal transduction [GO:0032483]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}; Peripheral membrane protein {ECO:0000269|PubMed:20937701}. Presynaptic cell membrane {ECO:0000269|PubMed:20937701}. Note=Associates to membranes via lipid-binding activity. {ECO:0000250|UniProtKB:Q8K382}.
Q8TEJ3	reviewed	SH3R3_HUMAN	E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4)	SH3RF3 POSH2 SH3MD4	Homo sapiens (Human)	882	FUNCTION: Has E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20696164}.		positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]		metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	
Q8TEK3	reviewed	DOT1L_HUMAN	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)	DOT1L KIAA1814 KMT4	Homo sapiens (Human)	1537	FUNCTION: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}.	MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.	DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; gene expression [GO:0010467]; heterochromatin formation [GO:0031507]; histone H3-K79 methylation [GO:0034729]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of transcription regulatory region DNA binding [GO:2000677]; telomere organization [GO:0032200]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K79 methyltransferase activity [GO:0031151]; histone H3K79 trimethyltransferase activity [GO:0140956]; histone methyltransferase activity [GO:0042054]; nucleic acid binding [GO:0003676]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K79 methyltransferase activity [GO:0031151]; histone H3K79 trimethyltransferase activity [GO:0140956]; histone methyltransferase activity [GO:0042054]; nucleic acid binding [GO:0003676]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; gene expression [GO:0010467]; heterochromatin formation [GO:0031507]; histone H3-K79 methylation [GO:0034729]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of transcription regulatory region DNA binding [GO:2000677]; telomere organization [GO:0032200]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15851025}.
Q8TEL6	reviewed	TP4AP_HUMAN	Short transient receptor potential channel 4-associated protein (Trp4-associated protein) (Trpc4-associated protein) (Protein TAP1) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS)	TRPC4AP C20orf188 TRRP4AP	Homo sapiens (Human)	797	FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control (PubMed:20551172, PubMed:29779948). The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway (PubMed:20551172, PubMed:29779948). The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (PubMed:29779948). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity). Involved in JNK activation via its interaction with TRAF2 (By similarity). Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1 (By similarity). {ECO:0000250|UniProtKB:Q9JLV2, ECO:0000269|PubMed:20551172, ECO:0000269|PubMed:29779948}.		calcium ion transmembrane transport [GO:0070588]; hair follicle maturation [GO:0048820]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]; phosphatase binding [GO:0019902]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; phosphatase binding [GO:0019902]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; calcium ion transmembrane transport [GO:0070588]; hair follicle maturation [GO:0048820]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:26038816}.
Q8TEM1	reviewed	PO210_HUMAN	Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa)	NUP210 KIAA0906 PSEC0245	Homo sapiens (Human)	1887	FUNCTION: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}.	MISCELLANEOUS: Recognized by antinuclear autoantibodies in primary biliary cirrhosis.; MISCELLANEOUS: Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.	mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]		endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:2195063}. Nucleus membrane {ECO:0000269|PubMed:2195063}; Single-pass type I membrane protein {ECO:0000269|PubMed:2195063}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:2195063}; Single-pass type I membrane protein {ECO:0000269|PubMed:2195063}.
Q8TEP8	reviewed	CE192_HUMAN	Centrosomal protein of 192 kDa (Cep192) (Cep192/SPD-2)	CEP192 KIAA1569 PP8407	Homo sapiens (Human)	2537	FUNCTION: Required for mitotic centrosome maturation and bipolar spindle assembly (PubMed:25042804, PubMed:17980596, PubMed:18207742). Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication (PubMed:25042804, PubMed:17980596, PubMed:18207742). Centrosome-specific activating scaffold for AURKA and PLK1 (PubMed:25042804). {ECO:0000269|PubMed:17980596, ECO:0000269|PubMed:18207742, ECO:0000269|PubMed:25042804}.		centriole replication [GO:0007099]; centrosome-templated microtubule nucleation [GO:0090222]; mitotic spindle assembly [GO:0090307]; protein localization to centrosome [GO:0071539]; response to bacterium [GO:0009617]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; pericentriolar material [GO:0000242]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099]	phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; pericentriolar material [GO:0000242]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; centriole replication [GO:0007099]; centrosome-templated microtubule nucleation [GO:0090222]; mitotic spindle assembly [GO:0090307]; protein localization to centrosome [GO:0071539]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:17980596, ECO:0000269|PubMed:18207742, ECO:0000269|PubMed:32060285}. Note=Pericentriolar location in mitotic centrosomes.
Q8TEQ6	reviewed	GEMI5_HUMAN	Gem-associated protein 5 (Gemin5)	GEMIN5	Homo sapiens (Human)	1508	FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601, PubMed:16314521). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}.		mRNA splicing, via spliceosome [GO:0000398]; protein-containing complex assembly [GO:0065003]; regulation of translation [GO:0006417]; spliceosomal snRNP assembly [GO:0000387]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Gemin2 complex [GO:0034718]; SMN-Sm protein complex [GO:0034719]	mRNA 3'-UTR binding [GO:0003730]; ribosome binding [GO:0043022]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; snRNA binding [GO:0017069]; U1 snRNA binding [GO:0030619]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Gemin2 complex [GO:0034718]; SMN-Sm protein complex [GO:0034719]; mRNA 3'-UTR binding [GO:0003730]; ribosome binding [GO:0043022]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; snRNA binding [GO:0017069]; U1 snRNA binding [GO:0030619]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622]; mRNA splicing, via spliceosome [GO:0000398]; protein-containing complex assembly [GO:0065003]; regulation of translation [GO:0006417]; spliceosomal snRNP assembly [GO:0000387]; translation [GO:0006412]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:11714716}. Nucleus, gem {ECO:0000269|PubMed:11714716}. Cytoplasm {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. {ECO:0000269|PubMed:11714716}.
Q8TEQ8	reviewed	PIGO_HUMAN	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O)	PIGO UNQ632/PRO1249	Homo sapiens (Human)	1089	FUNCTION: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. {ECO:0000269|PubMed:24049131, ECO:0000269|PubMed:28337824}.		GPI anchor biosynthetic process [GO:0006506]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	mannose-ethanolamine phosphotransferase activity [GO:0051377]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mannose-ethanolamine phosphotransferase activity [GO:0051377]; GPI anchor biosynthetic process [GO:0006506]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9JJI6}; Multi-pass membrane protein {ECO:0000255}.
Q8TER0	reviewed	SNED1_HUMAN	Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)	SNED1	Homo sapiens (Human)	1413			cell-matrix adhesion [GO:0007160]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; Notch binding [GO:0005112]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; cell-matrix adhesion [GO:0007160]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:33724335}. Note=Forms microfibrils within the extracellular matrix and colocalizes with fibronectin (FN1). {ECO:0000250|UniProtKB:Q70E20}.
Q8TER5	reviewed	ARH40_HUMAN	Rho guanine nucleotide exchange factor 40 (Protein SOLO)	ARHGEF40 SOLO	Homo sapiens (Human)	1519	FUNCTION: May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.		axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16143467}. Note=Concentrated in the perinuclear region.
Q8TES7	reviewed	FBF1_HUMAN	Fas-binding factor 1 (FBF-1) (Protein albatross)	FBF1 ALB KIAA1863	Homo sapiens (Human)	1133	FUNCTION: Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}.		apical junction assembly [GO:0043297]; cilium assembly [GO:0060271]; establishment of epithelial cell polarity [GO:0090162]	anchoring junction [GO:0070161]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; spindle pole [GO:0000922]		anchoring junction [GO:0070161]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; spindle pole [GO:0000922]; apical junction assembly [GO:0043297]; cilium assembly [GO:0060271]; establishment of epithelial cell polarity [GO:0090162]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Cell junction. Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to the apical junction complex (AJC) in epithelial cells.
Q8TEU7	reviewed	RPGF6_HUMAN	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)	RAPGEF6 PDZGEF2	Homo sapiens (Human)	1601	FUNCTION: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}.		microvillus assembly [GO:0030033]; positive regulation of GTPase activity [GO:0043547]; protein localization to plasma membrane [GO:0072659]; Ras protein signal transduction [GO:0007265]; regulation of GTPase activity [GO:0043087]	apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886]	GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidic acid binding [GO:0070300]; small GTPase binding [GO:0031267]	apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886]; GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidic acid binding [GO:0070300]; small GTPase binding [GO:0031267]; microvillus assembly [GO:0030033]; positive regulation of GTPase activity [GO:0043547]; protein localization to plasma membrane [GO:0072659]; Ras protein signal transduction [GO:0007265]; regulation of GTPase activity [GO:0043087]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11524421}. Cell membrane {ECO:0000269|PubMed:11524421}. Note=Upon binding to M-Ras, it translocates to the plasma membrane.
Q8TEU8	reviewed	WFKN2_HUMAN	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 (Growth and differentiation factor-associated serum protein 1) (GASP-1) (hGASP-1) (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein) (WFIKKN-related protein)	WFIKKN2 GASP1 WFIKKNRP UNQ9235/PRO31996	Homo sapiens (Human)	576	FUNCTION: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity). {ECO:0000250}.		muscle cell development [GO:0055001]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]; transforming growth factor beta receptor signaling pathway [GO:0007179]	extracellular space [GO:0005615]	metalloendopeptidase inhibitor activity [GO:0008191]; receptor antagonist activity [GO:0048019]; serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431]	extracellular space [GO:0005615]; metalloendopeptidase inhibitor activity [GO:0008191]; receptor antagonist activity [GO:0048019]; serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431]; muscle cell development [GO:0055001]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q8TEV9	reviewed	SMCR8_HUMAN	Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein)	SMCR8	Homo sapiens (Human)	937	FUNCTION: Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27193190, PubMed:27103069, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}.		autophagy [GO:0006914]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of exocytosis [GO:0045920]; negative regulation of gene expression [GO:0010629]; negative regulation of immune response [GO:0050777]; negative regulation of macroautophagy [GO:0016242]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of autophagosome maturation [GO:1901098]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008]; regulation of autophagy [GO:0010506]; regulation of TORC1 signaling [GO:1903432]	Atg1/ULK1 kinase complex [GO:1990316]; cell projection [GO:0042995]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor complex [GO:0032045]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; presynapse [GO:0098793]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]	Atg1/ULK1 kinase complex [GO:1990316]; cell projection [GO:0042995]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor complex [GO:0032045]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; presynapse [GO:0098793]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; autophagy [GO:0006914]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of exocytosis [GO:0045920]; negative regulation of gene expression [GO:0010629]; negative regulation of immune response [GO:0050777]; negative regulation of macroautophagy [GO:0016242]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of autophagosome maturation [GO:1901098]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008]; regulation of autophagy [GO:0010506]; regulation of TORC1 signaling [GO:1903432]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:28195531}. Nucleus {ECO:0000269|PubMed:28195531}. Presynapse {ECO:0000250|UniProtKB:Q3UMB5}. Postsynapse {ECO:0000250|UniProtKB:Q3UMB5}. Note=Localizes mainly in the cytoplasm. {ECO:0000269|PubMed:28195531}.
Q8TEW0	reviewed	PARD3_HUMAN	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)	PARD3 PAR3 PAR3A	Homo sapiens (Human)	1356	FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}.	MISCELLANEOUS: Antibodies against PARD3 are present in sera from patients with cutaneous T-cell lymphomas.	asymmetric cell division [GO:0008356]; axonogenesis [GO:0007409]; bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; establishment of cell polarity [GO:0030010]; establishment of centrosome localization [GO:0051660]; establishment of epithelial cell polarity [GO:0090162]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule cytoskeleton organization [GO:0000226]; myelination in peripheral nervous system [GO:0022011]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; positive regulation of myelination [GO:0031643]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein localization [GO:0008104]; protein targeting to membrane [GO:0006612]; protein-containing complex assembly [GO:0065003]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; internode region of axon [GO:0033269]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; tight junction [GO:0070160]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; internode region of axon [GO:0033269]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; tight junction [GO:0070160]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; asymmetric cell division [GO:0008356]; axonogenesis [GO:0007409]; bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; establishment of cell polarity [GO:0030010]; establishment of centrosome localization [GO:0051660]; establishment of epithelial cell polarity [GO:0090162]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule cytoskeleton organization [GO:0000226]; myelination in peripheral nervous system [GO:0022011]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; positive regulation of myelination [GO:0031643]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein localization [GO:0008104]; protein targeting to membrane [GO:0006612]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endomembrane system {ECO:0000269|PubMed:20332120}. Cell junction {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:27925688}. Cell junction, tight junction {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:27925688}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q99NH2}. Cell membrane {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:27925688}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20332120}. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Colocalized with SIRT2 in internode region of myelin sheath (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.
Q8TEW6	reviewed	DOK4_HUMAN	Docking protein 4 (Downstream of tyrosine kinase 4) (Insulin receptor substrate 5) (IRS-5) (IRS5)	DOK4	Homo sapiens (Human)	326	FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. {ECO:0000250}.		nervous system development [GO:0007399]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; cytosol [GO:0005829]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nervous system development [GO:0007399]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	
Q8TEW8	reviewed	PAR3L_HUMAN	Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein)	PARD3B ALS2CR19 PAR3B PAR3L	Homo sapiens (Human)	1205	FUNCTION: Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.		cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; establishment of cell polarity [GO:0030010]; establishment of centrosome localization [GO:0051660]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule cytoskeleton organization [GO:0000226]; protein localization [GO:0008104]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; endomembrane system [GO:0012505]; protein-containing complex [GO:0032991]	phosphatidylinositol binding [GO:0035091]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; endomembrane system [GO:0012505]; protein-containing complex [GO:0032991]; phosphatidylinositol binding [GO:0035091]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; establishment of cell polarity [GO:0030010]; establishment of centrosome localization [GO:0051660]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule cytoskeleton organization [GO:0000226]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Endomembrane system. Cell junction. Cell junction, tight junction. Note=Partially localized along the cell-cell contact region. Colocalizes with TJP1 to epithelial tight junctions.
Q8TEX9	reviewed	IPO4_HUMAN	Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)	IPO4 IMP4B RANBP4	Homo sapiens (Human)	1081	FUNCTION: Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR (PubMed:11823430, PubMed:16207705, PubMed:17682055, PubMed:21454524). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430, PubMed:16207705). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430, PubMed:16207705). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B) (PubMed:21454524, PubMed:29408485). Mediates the ligand-independent nuclear import of vitamin D receptor (VDR) (PubMed:16207705). In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS (PubMed:12610148). {ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:12610148, ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:17682055, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485}.		protein import into nucleus [GO:0006606]; protein localization to nucleus [GO:0034504]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267]; protein import into nucleus [GO:0006606]; protein localization to nucleus [GO:0034504]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:17682055}. Nucleus {ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:17682055}.
Q8TEY5	reviewed	CR3L4_HUMAN	Cyclic AMP-responsive element-binding protein 3-like protein 4 (cAMP-responsive element-binding protein 3-like protein 4) (Androgen-induced basic leucine zipper protein) (AIbZIP) (Attaching to CRE-like 1) (ATCE1) (Cyclic AMP-responsive element-binding protein 4) (CREB-4) (cAMP-responsive element-binding protein 4) (Transcript induced in spermiogenesis protein 40) (Tisp40) (hJAL) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 4]	CREB3L4 AIBZIP CREB4 JAL	Homo sapiens (Human)	395	FUNCTION: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). {ECO:0000250, ECO:0000269|PubMed:16236796}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to unfolded protein [GO:0006986]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to unfolded protein [GO:0006986]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=May also be located in Golgi apparatus.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 4]: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. {ECO:0000250}.
Q8TEY7	reviewed	UBP33_HUMAN	Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)	USP33 KIAA1097 VDU1	Homo sapiens (Human)	942	FUNCTION: Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19363159, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:23486064}.		axon guidance [GO:0007411]; cell migration [GO:0016477]; cellular response to starvation [GO:0009267]; centrosome duplication [GO:0051298]; endocytosis [GO:0006897]; negative regulation of protein binding [GO:0032091]; positive regulation of protein binding [GO:0032092]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; regulation of autophagy [GO:0010506]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; ubiquitin-dependent protein catabolic process [GO:0006511]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; VCB complex [GO:0030891]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; G protein-coupled receptor binding [GO:0001664]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; VCB complex [GO:0030891]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; G protein-coupled receptor binding [GO:0001664]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cellular response to starvation [GO:0009267]; centrosome duplication [GO:0051298]; endocytosis [GO:0006897]; negative regulation of protein binding [GO:0032091]; positive regulation of protein binding [GO:0032092]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; regulation of autophagy [GO:0010506]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:19118533}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23486064}. Note=Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (PubMed:23486064). {ECO:0000269|PubMed:23486064}.; SUBCELLULAR LOCATION: [Isoform 3]: Golgi apparatus {ECO:0000269|PubMed:21801292}.
Q8TEZ7	reviewed	PAQR8_HUMAN	Membrane progestin receptor beta (mPR beta) (Lysosomal membrane protein in brain 1) (Membrane progesterone P4 receptor beta) (Membrane progesterone receptor beta) (Progesterone and adipoQ receptor family member 8) (Progestin and adipoQ receptor family member 8) (Progestin and adipoQ receptor family member VIII)	PAQR8 C6orf33 LMPB1 MPRB	Homo sapiens (Human)	354	FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870). {ECO:0000250|UniProtKB:Q80ZE5, ECO:0000269|PubMed:23161870, ECO:0000303|PubMed:23763432}.	MISCELLANEOUS: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). {ECO:0000303|PubMed:23763432}.	oogenesis [GO:0048477]; response to steroid hormone [GO:0048545]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]; oogenesis [GO:0048477]; response to steroid hormone [GO:0048545]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11676489, ECO:0000303|PubMed:23763432}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with a lysosomal protein CTSD/cathepsin D. {ECO:0000269|PubMed:11676489}.
Q8TF01	reviewed	PNISR_HUMAN	Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)	PNISR C6orf111 SFRS18 SRRP130 HSPC261 HSPC306	Homo sapiens (Human)	805				cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]	RNA binding [GO:0003723]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:14578391}.
Q8TF09	reviewed	DLRB2_HUMAN	Dynein light chain roadblock-type 2 (Dynein light chain 2B, cytoplasmic) (Roadblock domain-containing protein 2)	DYNLRB2 DNCL2B DNLC2B ROBLD2	Homo sapiens (Human)	96	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.	MISCELLANEOUS: Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.	microtubule-based movement [GO:0007018]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; microtubule [GO:0005874]	dynein intermediate chain binding [GO:0045505]; microtubule motor activity [GO:0003777]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; microtubule [GO:0005874]; dynein intermediate chain binding [GO:0045505]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
Q8TF17	reviewed	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeat-containing protein 2	SH3TC2 KIAA1985 PP12494	Homo sapiens (Human)	1288			peripheral nervous system myelin maintenance [GO:0032287]; regulation of ERBB signaling pathway [GO:1901184]; regulation of intracellular protein transport [GO:0033157]	cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]		cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; peripheral nervous system myelin maintenance [GO:0032287]; regulation of ERBB signaling pathway [GO:1901184]; regulation of intracellular protein transport [GO:0033157]	
Q8TF30	reviewed	WHAMM_HUMAN	WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1)	WHAMM KIAA1971 WHDC1	Homo sapiens (Human)	809	FUNCTION: Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. {ECO:0000269|PubMed:18614018, ECO:0000269|PubMed:23027905, ECO:0000269|PubMed:23087206}.		actin filament organization [GO:0007015]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; focal adhesion assembly [GO:0048041]; lamellipodium assembly [GO:0030032]; plasma membrane tubulation [GO:0097320]; positive regulation of actin nucleation [GO:0051127]	cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]	actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267]; actin filament organization [GO:0007015]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; focal adhesion assembly [GO:0048041]; lamellipodium assembly [GO:0030032]; plasma membrane tubulation [GO:0097320]; positive regulation of actin nucleation [GO:0051127]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18614018}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:18614018}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18614018}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:18614018}. Note=Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules. {ECO:0000269|PubMed:18614018}.
Q8TF40	reviewed	FNIP1_HUMAN	Folliculin-interacting protein 1	FNIP1 KIAA1961	Homo sapiens (Human)	1166	FUNCTION: Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}.		B cell apoptotic process [GO:0001783]; B cell differentiation [GO:0030183]; cellular response to starvation [GO:0009267]; immature B cell differentiation [GO:0002327]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of lysosome organization [GO:1905672]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of pro-B cell differentiation [GO:2000973]; regulation of protein phosphorylation [GO:0001932]; TOR signaling [GO:0031929]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]	ATPase inhibitor activity [GO:0042030]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; ATPase inhibitor activity [GO:0042030]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; protein-folding chaperone binding [GO:0051087]; B cell apoptotic process [GO:0001783]; B cell differentiation [GO:0030183]; cellular response to starvation [GO:0009267]; immature B cell differentiation [GO:0002327]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of lysosome organization [GO:1905672]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of pro-B cell differentiation [GO:2000973]; regulation of protein phosphorylation [GO:0001932]; TOR signaling [GO:0031929]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:29848618}. Cytoplasm, cytosol {ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:29848618}. Note=Localizes to lysosome membrane in amino acid-depleted conditions and relocalizes to the cytosol upon refeeding (PubMed:29848618). Colocalizes with FLCN in the cytoplasm (PubMed:18663353). {ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:29848618}.
Q8TF42	reviewed	UBS3B_HUMAN	Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)	UBASH3B KIAA1959 STS1	Homo sapiens (Human)	649	FUNCTION: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17880946}.		collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of signal transduction [GO:0009968]; platelet aggregation [GO:0070527]; regulation of osteoclast differentiation [GO:0045670]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; protein tyrosine phosphatase activity [GO:0004725]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; protein tyrosine phosphatase activity [GO:0004725]; ubiquitin protein ligase binding [GO:0031625]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of signal transduction [GO:0009968]; platelet aggregation [GO:0070527]; regulation of osteoclast differentiation [GO:0045670]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000305}.
Q8TF46	reviewed	DI3L1_HUMAN	DIS3-like exonuclease 1 (EC 3.1.13.-)	DIS3L DIS3L1 KIAA1955	Homo sapiens (Human)	1054	FUNCTION: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389}.		RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]	centrosome [GO:0005813]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	3'-5'-RNA exonuclease activity [GO:0000175]; enzyme binding [GO:0019899]; RNA binding [GO:0003723]	centrosome [GO:0005813]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; 3'-5'-RNA exonuclease activity [GO:0000175]; enzyme binding [GO:0019899]; RNA binding [GO:0003723]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389}.
Q8TF47	reviewed	ZFP90_HUMAN	Zinc finger protein 90 homolog (Zfp-90) (Zinc finger protein 756)	ZFP90 KIAA1954 ZNF756	Homo sapiens (Human)	636	FUNCTION: Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. {ECO:0000269|PubMed:21284946}.; FUNCTION: [Isoform 2]: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg). {ECO:0000269|PubMed:23543754}.	MISCELLANEOUS: [Isoform 2]: Interacts (via 75-113 AA) with FOXP3. Interacts (via KRAB domain) with TRIM28. {ECO:0000269|PubMed:23543754}.	negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61967}. Note=Colocalizes with REST in the nucleus. {ECO:0000250|UniProtKB:Q61967}.
Q8TF50	reviewed	ZN526_HUMAN	Zinc finger protein 526	ZNF526 KIAA1951	Homo sapiens (Human)	670	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TF62	reviewed	AT8B4_HUMAN	Probable phospholipid-transporting ATPase IM (EC 7.6.2.1) (ATPase class I type 8B member 4) (P4-ATPase flippase complex alpha subunit ATP8B4)	ATP8B4 KIAA1939	Homo sapiens (Human)	1192	FUNCTION: Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). {ECO:0000305}.		Golgi organization [GO:0007030]; phospholipid translocation [GO:0045332]	Golgi apparatus [GO:0005794]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]	Golgi apparatus [GO:0005794]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; Golgi organization [GO:0007030]; phospholipid translocation [GO:0045332]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20947505}; Multi-pass membrane protein {ECO:0000269|PubMed:20947505}. Golgi apparatus {ECO:0000269|PubMed:20947505}.
Q8TF63	reviewed	DCNP1_HUMAN	Dendritic cell nuclear protein 1 (Dendritic cell nuclear protein-1) (Dendritic cell-associated nuclear protein)	DCANP1 C5orf20 DCNP1	Homo sapiens (Human)	244	FUNCTION: Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter. {ECO:0000269|PubMed:20693543}.		auditory behavior [GO:0031223]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; craniofacial suture morphogenesis [GO:0097094]; genitalia development [GO:0048806]; genitalia morphogenesis [GO:0035112]; hard palate morphogenesis [GO:1905748]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; learned vocalization behavior [GO:0098583]; mastication [GO:0071626]; negative regulation of relaxation of muscle [GO:1901078]; negative regulation of saliva secretion [GO:1905747]; neuromuscular process controlling balance [GO:0050885]; peristalsis [GO:0030432]; regulation of muscle organ development [GO:0048634]; thorax and anterior abdomen determination [GO:0007356]; trigeminal nerve development [GO:0021559]; vestibulocochlear nerve formation [GO:0021650]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; auditory behavior [GO:0031223]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; craniofacial suture morphogenesis [GO:0097094]; genitalia development [GO:0048806]; genitalia morphogenesis [GO:0035112]; hard palate morphogenesis [GO:1905748]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; learned vocalization behavior [GO:0098583]; mastication [GO:0071626]; negative regulation of relaxation of muscle [GO:1901078]; negative regulation of saliva secretion [GO:1905747]; neuromuscular process controlling balance [GO:0050885]; peristalsis [GO:0030432]; regulation of muscle organ development [GO:0048634]; thorax and anterior abdomen determination [GO:0007356]; trigeminal nerve development [GO:0021559]; vestibulocochlear nerve formation [GO:0021650]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11798177, ECO:0000269|PubMed:20693543}. Cytoplasm {ECO:0000269|PubMed:20693543}. Note=Particularly on the periphery. Colocalizes with corticotropin-releasing hormone (CRH) in parvocellular neurons in the paraventricular nucleus. {ECO:0000269|PubMed:20693543}.
Q8TF65	reviewed	GIPC2_HUMAN	PDZ domain-containing protein GIPC2	GIPC2	Homo sapiens (Human)	315				cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8TF66	reviewed	LRC15_HUMAN	Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid homolog) (hLib)	LRRC15 LIB	Homo sapiens (Human)	581	FUNCTION: (Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein (PubMed:36735681, PubMed:36757924, PubMed:36228039). Does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes in trans SARS-CoV-2 infection of ACE2(+) cells when expressed on nearby cells (PubMed:36757924, PubMed:36228039). {ECO:0000269|PubMed:36228039, ECO:0000269|PubMed:36735681, ECO:0000269|PubMed:36757924}.		negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of cell migration [GO:0030335]; receptor-mediated virion attachment to host cell [GO:0046813]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	collagen binding [GO:0005518]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; protein sequestering activity [GO:0140311]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; collagen binding [GO:0005518]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; protein sequestering activity [GO:0140311]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of cell migration [GO:0030335]; receptor-mediated virion attachment to host cell [GO:0046813]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:36228039, ECO:0000269|PubMed:36735681, ECO:0000269|PubMed:36757924}; Single-pass type I membrane protein {ECO:0000255}.
Q8TF71	reviewed	MOT10_HUMAN	Monocarboxylate transporter 10 (MCT 10) (Aromatic amino acid transporter 1) (Solute carrier family 16 member 10) (T-type amino acid transporter 1)	SLC16A10 MCT10 TAT1	Homo sapiens (Human)	515	FUNCTION: Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity). {ECO:0000250|UniProtKB:Q3U9N9, ECO:0000269|PubMed:11827462, ECO:0000269|PubMed:18337592, ECO:0000269|PubMed:28754537}.		amino acid transport [GO:0006865]; aromatic amino acid transport [GO:0015801]; thyroid hormone generation [GO:0006590]; thyroid hormone transport [GO:0070327]; thyroid-stimulating hormone secretion [GO:0070460]	basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; aromatic amino acid transmembrane transporter activity [GO:0015173]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-tryptophan transmembrane transporter activity [GO:0015196]; L-tyrosine transmembrane transporter activity [GO:0005302]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; thyroid hormone transmembrane transporter activity [GO:0015349]	basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; aromatic amino acid transmembrane transporter activity [GO:0015173]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-tryptophan transmembrane transporter activity [GO:0015196]; L-tyrosine transmembrane transporter activity [GO:0005302]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; thyroid hormone transmembrane transporter activity [GO:0015349]; amino acid transport [GO:0006865]; aromatic amino acid transport [GO:0015801]; thyroid hormone generation [GO:0006590]; thyroid hormone transport [GO:0070327]; thyroid-stimulating hormone secretion [GO:0070460]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11827462, ECO:0000269|PubMed:18337592, ECO:0000269|PubMed:28754537}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q91Y77}; Multi-pass membrane protein {ECO:0000255}.
Q8TF72	reviewed	SHRM3_HUMAN	Protein Shroom3 (Shroom-related protein) (hShrmL)	SHROOM3 KIAA1481 SHRML MSTP013	Homo sapiens (Human)	1996	FUNCTION: Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.		actin filament organization [GO:0007015]; apical protein localization [GO:0045176]; cell morphogenesis [GO:0000902]; cellular pigment accumulation [GO:0043482]; pattern specification process [GO:0007389]; regulation of cell shape [GO:0008360]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cortical actin cytoskeleton [GO:0030864]; cytoskeleton [GO:0005856]; microtubule [GO:0005874]	actin filament binding [GO:0051015]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cortical actin cytoskeleton [GO:0030864]; cytoskeleton [GO:0005856]; microtubule [GO:0005874]; actin filament binding [GO:0051015]; actin filament organization [GO:0007015]; apical protein localization [GO:0045176]; cell morphogenesis [GO:0000902]; cellular pigment accumulation [GO:0043482]; pattern specification process [GO:0007389]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9QXN0}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QXN0}. Apical cell membrane {ECO:0000250|UniProtKB:Q9QXN0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9QXN0}. Note=Colocalizes with F-actin in stress fibers and adherens junctions. {ECO:0000250|UniProtKB:Q9QXN0}.
Q8TF74	reviewed	WIPF2_HUMAN	WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)	WIPF2 WICH WIRE PP10631	Homo sapiens (Human)	440	FUNCTION: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}.	MISCELLANEOUS: Access to the profilin-binding site is masked in the full-length protein.		cytoskeleton [GO:0005856]; cytosol [GO:0005829]	actin binding [GO:0003779]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; actin binding [GO:0003779]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. Note=Localized to stress fibers and bundles of actin filaments.
Q8TF76	reviewed	HASP_HUMAN	Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase)	HASPIN GSG2	Homo sapiens (Human)	798	FUNCTION: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}.		intracellular signal transduction [GO:0035556]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to chromosome, centromeric region [GO:0071459]; protein phosphorylation [GO:0006468]	centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	ATP binding [GO:0005524]; histone H3T3 kinase activity [GO:0072354]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]	centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; ATP binding [GO:0005524]; histone H3T3 kinase activity [GO:0072354]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; intracellular signal transduction [GO:0035556]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to chromosome, centromeric region [GO:0071459]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15681610}. Chromosome {ECO:0000269|PubMed:15681610}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15681610}. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.
Q8WTP8	reviewed	AEN_HUMAN	Apoptosis-enhancing nuclease (EC 3.1.-.-) (Interferon-stimulated 20 kDa exonuclease-like 1)	AEN ISG20L1 SBBI58	Homo sapiens (Human)	325	FUNCTION: Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. {ECO:0000269|PubMed:16171785, ECO:0000269|PubMed:18264133}.		intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; response to ionizing radiation [GO:0010212]	nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA exonuclease activity [GO:0004529]; exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676]	nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA exonuclease activity [GO:0004529]; exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.
Q8WTQ1	reviewed	D104A_HUMAN	Beta-defensin 104 (Beta-defensin 4) (BD-4) (DEFB-4) (hBD-4) (Defensin, beta 104)	DEFB104A DEFB104 DEFB4; DEFB104B	Homo sapiens (Human)	72	FUNCTION: Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. {ECO:0000269|PubMed:11481241}.		cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; monocyte chemotaxis [GO:0002548]; positive chemotaxis [GO:0050918]	extracellular region [GO:0005576]	chemoattractant activity [GO:0042056]	extracellular region [GO:0005576]; chemoattractant activity [GO:0042056]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; monocyte chemotaxis [GO:0002548]; positive chemotaxis [GO:0050918]	SUBCELLULAR LOCATION: Secreted.
Q8WTQ7	reviewed	GRK7_HUMAN	Rhodopsin kinase GRK7 (EC 2.7.11.14) (G protein-coupled receptor kinase 7) (G protein-coupled receptor kinase GRK7)	GRK7 GPRK7	Homo sapiens (Human)	553	FUNCTION: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). {ECO:0000269|PubMed:15946941}.	MISCELLANEOUS: Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.	protein autophosphorylation [GO:0046777]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; regulation of signal transduction [GO:0009966]; signal transduction [GO:0007165]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; photoreceptor disc membrane [GO:0097381]	ATP binding [GO:0005524]; rhodopsin kinase activity [GO:0050254]	cytoplasm [GO:0005737]; photoreceptor disc membrane [GO:0097381]; ATP binding [GO:0005524]; rhodopsin kinase activity [GO:0050254]; protein autophosphorylation [GO:0046777]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; regulation of signal transduction [GO:0009966]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8WMV0}; Lipid-anchor {ECO:0000250|UniProtKB:Q8WMV0}.
Q8WTR2	reviewed	DUS19_HUMAN	Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1) (SAPK pathway-regulating phosphatase 1)	DUSP19 DUSP17 LMWDSP3 SKRP1	Homo sapiens (Human)	217	FUNCTION: Has a dual specificity toward Ser/Thr and Tyr-containing proteins. {ECO:0000269|PubMed:12479873}.		dephosphorylation [GO:0016311]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860]	cytoplasm [GO:0005737]	JUN kinase phosphatase activity [GO:0008579]; MAP-kinase scaffold activity [GO:0005078]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; myosin phosphatase activity [GO:0017018]; protein kinase activator activity [GO:0030295]; protein kinase inhibitor activity [GO:0004860]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; JUN kinase phosphatase activity [GO:0008579]; MAP-kinase scaffold activity [GO:0005078]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; myosin phosphatase activity [GO:0017018]; protein kinase activator activity [GO:0030295]; protein kinase inhibitor activity [GO:0004860]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; dephosphorylation [GO:0016311]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860]	
Q8WTR4	reviewed	GDPD5_HUMAN	Glycerophosphodiester phosphodiesterase domain-containing protein 5 (Glycerophosphocholine phosphodiesterase GDPD5) (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 2) (Phosphoinositide phospholipase C GDPD5) (EC 3.1.4.11)	GDPD5 GDE2 PP6037 PP9363 UNQ1850/PRO3580	Homo sapiens (Human)	605	FUNCTION: Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity). {ECO:0000250|UniProtKB:Q3KTM2, ECO:0000250|UniProtKB:Q640M6}.		lipid metabolic process [GO:0006629]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666]	endomembrane system [GO:0012505]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	glycerophosphocholine phosphodiesterase activity [GO:0047389]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; phosphatidylinositol phospholipase C activity [GO:0004435]	endomembrane system [GO:0012505]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; glycerophosphocholine phosphodiesterase activity [GO:0047389]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; phosphatidylinositol phospholipase C activity [GO:0004435]; lipid metabolic process [GO:0006629]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250|UniProtKB:Q640M6}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q640M6}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q640M6}. Note=In a punctate perinuclear pattern. {ECO:0000250|UniProtKB:Q640M6}.
Q8WTR7	reviewed	ZN473_HUMAN	Zinc finger protein 473 (Zinc finger protein 100 homolog) (Zfp-100)	ZNF473 KIAA1141 ZFP100	Homo sapiens (Human)	871	FUNCTION: Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases. {ECO:0000269|PubMed:11782445, ECO:0000269|PubMed:16714279, ECO:0000269|PubMed:16914750}.		mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; regulation of transcription by RNA polymerase II [GO:0006357]	Cajal body [GO:0015030]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	Cajal body [GO:0015030]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16714279}. Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.
Q8WTS1	reviewed	ABHD5_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (EC 2.3.1.51) (Abhydrolase domain-containing protein 5) (Lipid droplet-binding protein CGI-58)	ABHD5 NCIE2 CGI-58	Homo sapiens (Human)	349	FUNCTION: Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid (PubMed:18606822). Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:18832586). Regulates lipid droplet fusion (By similarity). {ECO:0000250|UniProtKB:Q9DBL9, ECO:0000269|PubMed:16679289, ECO:0000269|PubMed:18606822, ECO:0000269|PubMed:18832586}.		cell differentiation [GO:0030154]; fatty acid metabolic process [GO:0006631]; lipid homeostasis [GO:0055088]; negative regulation of sequestering of triglyceride [GO:0010891]; phosphatidic acid biosynthetic process [GO:0006654]; positive regulation of triglyceride catabolic process [GO:0010898]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; carboxylic ester hydrolase activity [GO:0052689]; lipase activator activity [GO:0060229]; lysophosphatidic acid acyltransferase activity [GO:0042171]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; carboxylic ester hydrolase activity [GO:0052689]; lipase activator activity [GO:0060229]; lysophosphatidic acid acyltransferase activity [GO:0042171]; cell differentiation [GO:0030154]; fatty acid metabolic process [GO:0006631]; lipid homeostasis [GO:0055088]; negative regulation of sequestering of triglyceride [GO:0010891]; phosphatidic acid biosynthetic process [GO:0006654]; positive regulation of triglyceride catabolic process [GO:0010898]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18832586}. Lipid droplet {ECO:0000250|UniProtKB:Q9DBL9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9DBL9}. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity). {ECO:0000250}.
Q8WTS6	reviewed	SETD7_HUMAN	Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9)	SETD7 KIAA1717 KMT7 SET7 SET9	Homo sapiens (Human)	366	FUNCTION: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12588998, PubMed:12540855, PubMed:16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12588998, PubMed:12540855, PubMed:16141209). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:16141209, PubMed:12588998). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209). Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:15099517, PubMed:35210392, PubMed:15525938, PubMed:16415881). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed:15099517, PubMed:16415881). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed:17108971, PubMed:15525938, PubMed:16415881). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity). {ECO:0000250|UniProtKB:Q8VHL1, ECO:0000269|PubMed:11779497, ECO:0000269|PubMed:11850410, ECO:0000269|PubMed:12540855, ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209, ECO:0000269|PubMed:16415881, ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:35210392}.		chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; heterochromatin organization [GO:0070828]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; positive regulation of DNA-templated transcription [GO:0045893]; response to ethanol [GO:0045471]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone methyltransferase activity [GO:0042054]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone methyltransferase activity [GO:0042054]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; heterochromatin organization [GO:0070828]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; positive regulation of DNA-templated transcription [GO:0045893]; response to ethanol [GO:0045471]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:11779497}. Chromosome {ECO:0000305|PubMed:11850410}.
Q8WTT0	reviewed	CLC4C_HUMAN	C-type lectin domain family 4 member C (Blood dendritic cell antigen 2) (BDCA-2) (C-type lectin superfamily member 7) (Dendritic lectin) (CD antigen CD303)	CLEC4C BDCA2 CLECSF11 CLECSF7 DLEC HECL UNQ9361/PRO34150	Homo sapiens (Human)	213	FUNCTION: Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283). {ECO:0000269|PubMed:11748283, ECO:0000269|PubMed:21880719, ECO:0000269|PubMed:25995448}.		adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]	external side of plasma membrane [GO:0009897]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]	external side of plasma membrane [GO:0009897]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11748283, ECO:0000269|PubMed:21880719}; Single-pass type II membrane protein {ECO:0000305}.
Q8WTT2	reviewed	NOC3L_HUMAN	Nucleolar complex protein 3 homolog (NOC3 protein homolog) (Factor for adipocyte differentiation 24) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein)	NOC3L AD24 C10orf117 FAD24	Homo sapiens (Human)	800	FUNCTION: May be required for adipogenesis. {ECO:0000250}.		DNA replication initiation [GO:0006270]; fat cell differentiation [GO:0045444]	mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; RNA binding [GO:0003723]	mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; RNA binding [GO:0003723]; DNA replication initiation [GO:0006270]; fat cell differentiation [GO:0045444]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus speckle.
Q8WTU0	reviewed	DDI1_HUMAN	Protein DDI1 homolog 1 (EC 3.4.23.-)	DDI1	Homo sapiens (Human)	396	FUNCTION: Probable aspartic protease (Probable). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:21266539, ECO:0000305|PubMed:29290612}.		cellular response to hydroxyurea [GO:0072711]; proteasomal protein catabolic process [GO:0010498]; regulation of DNA stability [GO:0097752]; regulation of protein stability [GO:0031647]		aspartic-type endopeptidase activity [GO:0004190]	aspartic-type endopeptidase activity [GO:0004190]; cellular response to hydroxyurea [GO:0072711]; proteasomal protein catabolic process [GO:0010498]; regulation of DNA stability [GO:0097752]; regulation of protein stability [GO:0031647]	
Q8WTV0	reviewed	SCRB1_HUMAN	Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36)	SCARB1 CD36L1 CLA1	Homo sapiens (Human)	552	FUNCTION: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218). {ECO:0000269|PubMed:12016218, ECO:0000269|PubMed:12519372, ECO:0000269|PubMed:16020694, ECO:0000269|PubMed:21226579, ECO:0000269|PubMed:26965621}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). {ECO:0000269|PubMed:12356718, ECO:0000269|PubMed:18000990}.; FUNCTION: (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus. {ECO:0000269|PubMed:16020694}.; FUNCTION: (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding. {ECO:0000269|PubMed:33244168}.	MISCELLANEOUS: [Isoform 3]: May be due to a competing donor splice site.	adhesion of symbiont to host [GO:0044406]; blood vessel endothelial cell migration [GO:0043534]; carotenoid transport [GO:0046867]; cholesterol catabolic process [GO:0006707]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; detection of lipopolysaccharide [GO:0032497]; endothelial cell proliferation [GO:0001935]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; intestinal lipid absorption [GO:0098856]; lipopolysaccharide transport [GO:0015920]; low-density lipoprotein particle clearance [GO:0034383]; phospholipid transport [GO:0015914]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of triglyceride biosynthetic process [GO:0010867]; recognition of apoptotic cell [GO:0043654]; regulation of phagocytosis [GO:0050764]; regulation of phosphatidylcholine catabolic process [GO:0010899]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; vitamin transmembrane transport [GO:0035461]; wound healing [GO:0042060]	caveola [GO:0005901]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	1-phosphatidylinositol binding [GO:0005545]; amyloid-beta binding [GO:0001540]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein binding [GO:0034185]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor activity [GO:0070506]; lipid binding [GO:0008289]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; low-density lipoprotein particle binding [GO:0030169]; phosphatidylserine binding [GO:0001786]; scavenger receptor activity [GO:0005044]; virus receptor activity [GO:0001618]	caveola [GO:0005901]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; 1-phosphatidylinositol binding [GO:0005545]; amyloid-beta binding [GO:0001540]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein binding [GO:0034185]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor activity [GO:0070506]; lipid binding [GO:0008289]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; low-density lipoprotein particle binding [GO:0030169]; phosphatidylserine binding [GO:0001786]; scavenger receptor activity [GO:0005044]; virus receptor activity [GO:0001618]; adhesion of symbiont to host [GO:0044406]; blood vessel endothelial cell migration [GO:0043534]; carotenoid transport [GO:0046867]; cholesterol catabolic process [GO:0006707]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; detection of lipopolysaccharide [GO:0032497]; endothelial cell proliferation [GO:0001935]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; intestinal lipid absorption [GO:0098856]; lipopolysaccharide transport [GO:0015920]; low-density lipoprotein particle clearance [GO:0034383]; phospholipid transport [GO:0015914]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of triglyceride biosynthetic process [GO:0010867]; recognition of apoptotic cell [GO:0043654]; regulation of phagocytosis [GO:0050764]; regulation of phosphatidylcholine catabolic process [GO:0010899]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; vitamin transmembrane transport [GO:0035461]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26965621}; Multi-pass membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:Q61009}; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
Q8WTV1	reviewed	THAP3_HUMAN	THAP domain-containing protein 3	THAP3	Homo sapiens (Human)	239	FUNCTION: Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. {ECO:0000269|PubMed:20200153}.		positive regulation of transcription by RNA polymerase II [GO:0045944]		DNA binding [GO:0003677]; metal ion binding [GO:0046872]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; positive regulation of transcription by RNA polymerase II [GO:0045944]	
Q8WTW3	reviewed	COG1_HUMAN	Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1)	COG1 KIAA1381 LDLB	Homo sapiens (Human)	980	FUNCTION: Required for normal Golgi function. {ECO:0000250}.		glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588]		Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588]; glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:11980916}; Peripheral membrane protein {ECO:0000305|PubMed:11980916}; Cytoplasmic side {ECO:0000305|PubMed:11980916}.
Q8WTW4	reviewed	NPRL2_HUMAN	GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4)	NPRL2 TUSC4	Homo sapiens (Human)	380	FUNCTION: Catalytic component of the GATOR1 complex, a multiprotein complex that functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:29590090, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:29590090, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is ubiquitinated and inhibited by GATOR2 (PubMed:23723238, PubMed:36528027). Within the GATOR1 complex, NPRL2 constitutes the catalytic subunit that mediates the GAP activity (PubMed:30651352, PubMed:35338845). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:30651352, ECO:0000269|PubMed:35338845, ECO:0000269|PubMed:36528027}.; FUNCTION: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling (PubMed:18616680). Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues (PubMed:18616680). May act as a tumor suppressor (PubMed:18616680). Suppresses cell growth and enhances sensitivity to various anticancer drugs (PubMed:18616680). {ECO:0000269|PubMed:18616680}.		cellular response to amino acid starvation [GO:0034198]; negative regulation of kinase activity [GO:0033673]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]	GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765]; vacuolar membrane [GO:0005774]	GTPase activator activity [GO:0005096]	GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765]; vacuolar membrane [GO:0005774]; GTPase activator activity [GO:0005096]; cellular response to amino acid starvation [GO:0034198]; negative regulation of kinase activity [GO:0033673]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28199306}. Note=Localization to lysosomes is mediated by the KICSTOR complex and is amino acid-independent. {ECO:0000269|PubMed:28199306}.
Q8WTX7	reviewed	CAST1_HUMAN	Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3)	CASTOR1 GATSL3	Homo sapiens (Human)	329	FUNCTION: Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:26972053, PubMed:27487210, PubMed:33594058). As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1 (PubMed:26972053, PubMed:27487210, PubMed:33594058). Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway (PubMed:26972053, PubMed:27487210, PubMed:33594058). {ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:33594058}.		cellular response to amino acid starvation [GO:0034198]; cellular response to L-arginine [GO:1903577]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of TORC1 signaling [GO:1904263]	cytosol [GO:0005829]	arginine binding [GO:0034618]; identical protein binding [GO:0042802]; protein sequestering activity [GO:0140311]; small molecule sensor activity [GO:0140299]	cytosol [GO:0005829]; arginine binding [GO:0034618]; identical protein binding [GO:0042802]; protein sequestering activity [GO:0140311]; small molecule sensor activity [GO:0140299]; cellular response to amino acid starvation [GO:0034198]; cellular response to L-arginine [GO:1903577]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of TORC1 signaling [GO:1904263]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:26972053}.
Q8WTX9	reviewed	ZDHC1_HUMAN	Palmitoyltransferase ZDHHC1 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 1) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) (Zinc finger protein 377)	ZDHHC1 C16orf1 ZNF377	Homo sapiens (Human)	485	FUNCTION: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (By similarity). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation. {ECO:0000250|UniProtKB:Q8R0N9}.; FUNCTION: Has also a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response (PubMed:25299331). Functions as an activator of STING1 by promoting its cGAMP-induced oligomerization and the recruitment of downstream signaling components (PubMed:25299331). {ECO:0000269|PubMed:25299331}.		antiviral innate immune response [GO:0140374]; positive regulation of defense response to virus by host [GO:0002230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]	DNA binding [GO:0003677]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; DNA binding [GO:0003677]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; antiviral innate immune response [GO:0140374]; positive regulation of defense response to virus by host [GO:0002230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q8R0N9}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16647879, ECO:0000269|PubMed:25299331}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:25299331}.
Q8WU03	reviewed	GLYL2_HUMAN	Glycine N-acyltransferase-like protein 2 (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase-like protein 2)	GLYATL2	Homo sapiens (Human)	294	FUNCTION: Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine (PubMed:22475485, PubMed:20305126). Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine (PubMed:20305126). {ECO:0000269|PubMed:20305126, ECO:0000269|PubMed:22475485}.		long-chain fatty acid catabolic process [GO:0042758]; medium-chain fatty acid catabolic process [GO:0051793]; monounsaturated fatty acid catabolic process [GO:1903965]	endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]	glycine N-acyltransferase activity [GO:0047961]	endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; glycine N-acyltransferase activity [GO:0047961]; long-chain fatty acid catabolic process [GO:0042758]; medium-chain fatty acid catabolic process [GO:0051793]; monounsaturated fatty acid catabolic process [GO:1903965]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:20305126}.
Q8WU08	reviewed	ST32A_HUMAN	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (Yet another novel kinase 1)	STK32A YANK1	Homo sapiens (Human)	396			intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	plasma membrane [GO:0005886]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	plasma membrane [GO:0005886]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor {ECO:0000269|PubMed:25043870}.
Q8WU10	reviewed	PYRD1_HUMAN	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (EC 1.8.1.-)	PYROXD1	Homo sapiens (Human)	500	FUNCTION: Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (PubMed:27745833). Required for normal sarcomere structure and muscle fiber integrity (By similarity). {ECO:0000250|UniProtKB:Q6PBT5, ECO:0000269|PubMed:27745833}.		cellular response to oxidative stress [GO:0034599]	nucleus [GO:0005634]; sarcomere [GO:0030017]	flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity [GO:0016491]	nucleus [GO:0005634]; sarcomere [GO:0030017]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity [GO:0016491]; cellular response to oxidative stress [GO:0034599]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27745833}. Cytoplasm {ECO:0000269|PubMed:27745833}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:27745833}.
Q8WU17	reviewed	RN139_HUMAN	E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein)	RNF139 TRC8	Homo sapiens (Human)	664	FUNCTION: E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death (PubMed:10500182, PubMed:12032852, PubMed:17016439). Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) (PubMed:19720873). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression (PubMed:19706601, PubMed:20068067). Involved in the sterol-accelerated degradation of HMGCR (PubMed:22143767, PubMed:23223569). This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane (PubMed:22143767). In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:22143767, PubMed:23223569). Required for INSIG1 ubiquitination (PubMed:20068067). May be required for EIF3 complex ubiquitination (PubMed:20068067). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12032852, ECO:0000269|PubMed:17016439, ECO:0000269|PubMed:19706601, ECO:0000269|PubMed:19720873, ECO:0000269|PubMed:20068067, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:23223569}.		ERAD pathway [GO:0036503]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of translation [GO:0017148]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein processing [GO:0070613]	Derlin-1 retrotranslocation complex [GO:0036513]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	Derlin-1 retrotranslocation complex [GO:0036513]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; ERAD pathway [GO:0036503]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of translation [GO:0017148]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein processing [GO:0070613]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12032852}; Multi-pass membrane protein {ECO:0000269|PubMed:12032852}.
Q8WU20	reviewed	FRS2_HUMAN	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)	FRS2	Homo sapiens (Human)	508	FUNCTION: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}.		anterior/posterior axis specification, embryo [GO:0008595]; fibroblast growth factor receptor signaling pathway [GO:0008543]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; gastrulation with mouth forming second [GO:0001702]; lens fiber cell development [GO:0070307]; lens placode formation involved in camera-type eye formation [GO:0046619]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; neuroblast proliferation [GO:0007405]; organ induction [GO:0001759]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of apoptotic process [GO:0042981]; regulation of epithelial cell proliferation [GO:0050678]; regulation of ERK1 and ERK2 cascade [GO:0070372]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; ventricular septum development [GO:0003281]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886]	fibroblast growth factor receptor binding [GO:0005104]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatase activator activity [GO:0019211]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886]; fibroblast growth factor receptor binding [GO:0005104]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatase activator activity [GO:0019211]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; anterior/posterior axis specification, embryo [GO:0008595]; fibroblast growth factor receptor signaling pathway [GO:0008543]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; gastrulation with mouth forming second [GO:0001702]; lens fiber cell development [GO:0070307]; lens placode formation involved in camera-type eye formation [GO:0046619]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; neuroblast proliferation [GO:0007405]; organ induction [GO:0001759]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of apoptotic process [GO:0042981]; regulation of epithelial cell proliferation [GO:0050678]; regulation of ERK1 and ERK2 cascade [GO:0070372]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Endomembrane system. Note=Cytoplasmic, membrane-bound.
Q8WU39	reviewed	MZB1_HUMAN	Marginal zone B- and B1-cell-specific protein (Mesenteric estrogen-dependent adipose 7) (MEDA-7) (Plasma cell-induced resident endoplasmic reticulum protein) (Plasma cell-induced resident ER protein) (pERp1) (Proapoptotic caspase adapter protein)	MZB1 MEDA7 PACAP HSPC190	Homo sapiens (Human)	189	FUNCTION: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. {ECO:0000250, ECO:0000269|PubMed:11350957, ECO:0000269|PubMed:21688198}.; FUNCTION: Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.	MISCELLANEOUS: [Isoform 1]: Major.	apoptotic process [GO:0006915]; integrin activation [GO:0033622]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of immunoglobulin production [GO:0002639]; regulation of B cell proliferation [GO:0030888]; regulation of cell population proliferation [GO:0042127]; regulation of insulin receptor signaling pathway [GO:0046626]	cytoplasm [GO:0005737]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]		cytoplasm [GO:0005737]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; apoptotic process [GO:0006915]; integrin activation [GO:0033622]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of immunoglobulin production [GO:0002639]; regulation of B cell proliferation [GO:0030888]; regulation of cell population proliferation [GO:0042127]; regulation of insulin receptor signaling pathway [GO:0046626]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum lumen {ECO:0000269|PubMed:19805157}. Secreted {ECO:0000269|PubMed:21688198}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11350957}. Note=Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).
Q8WU58	reviewed	F222B_HUMAN	Protein FAM222B	FAM222B C17orf63	Homo sapiens (Human)	562				nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	
Q8WU66	reviewed	TSEAR_HUMAN	Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)	TSPEAR C21orf29	Homo sapiens (Human)	669	FUNCTION: Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway (PubMed:27736875). May play a role in development or function of the auditory system (PubMed:22678063). {ECO:0000269|PubMed:22678063, ECO:0000269|PubMed:27736875}.		hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]	cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]		cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]; hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:J3S6Y1}. Cell surface {ECO:0000250|UniProtKB:J3S6Y1}. Cell projection, stereocilium {ECO:0000250|UniProtKB:J3S6Y1}. Note=Secreted protein which may bind to the cell surface via a membrane receptor. {ECO:0000250|UniProtKB:J3S6Y1}.
Q8WU67	reviewed	ABHD3_HUMAN	Phospholipase ABHD3 (EC 3.1.1.32) (EC 3.1.1.4) (Abhydrolase domain-containing protein 3)	ABHD3	Homo sapiens (Human)	409	FUNCTION: Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids. {ECO:0000250|UniProtKB:Q91ZH7}.		medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylcholine metabolic process [GO:0046470]	plasma membrane [GO:0005886]	1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; acetylesterase activity [GO:0008126]; acylglycerol lipase activity [GO:0047372]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]	plasma membrane [GO:0005886]; 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; acetylesterase activity [GO:0008126]; acylglycerol lipase activity [GO:0047372]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylcholine metabolic process [GO:0046470]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8WU68	reviewed	U2AF4_HUMAN	Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3)	U2AF1L4 U2AF1-RS3 U2AF1L3	Homo sapiens (Human)	220	FUNCTION: RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}.		mRNA splicing, via spliceosome [GO:0000398]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701]	metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701]; metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BGJ9}. Nucleus speckle {ECO:0000250|UniProtKB:Q8BGJ9}. Cytoplasm {ECO:0000250|UniProtKB:Q8BGJ9}. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo-cytoplasmic shuttling. {ECO:0000250|UniProtKB:Q8BGJ9}.
Q8WU79	reviewed	SMAP2_HUMAN	Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like)	SMAP2 SMAP1L	Homo sapiens (Human)	429	FUNCTION: GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). {ECO:0000250}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Cytoplasm. Note=Detected in multiple foci throughout the cytoplasm and in juxtanuclear structures. {ECO:0000250}.
Q8WU90	reviewed	ZC3HF_HUMAN	Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4)	ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730	Homo sapiens (Human)	426	FUNCTION: Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}.		cytokine-mediated signaling pathway [GO:0019221]; cytoplasmic translation [GO:0002181]; positive regulation of GTPase activity [GO:0043547]	cytosol [GO:0005829]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; cytokine-mediated signaling pathway [GO:0019221]; cytoplasmic translation [GO:0002181]; positive regulation of GTPase activity [GO:0043547]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15676025, ECO:0000269|PubMed:19819225}. Nucleus {ECO:0000250}. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.
Q8WUA4	reviewed	TF3C2_HUMAN	General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta)	GTF3C2 KIAA0011	Homo sapiens (Human)	911	FUNCTION: Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.		5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; tRNA transcription by RNA polymerase III [GO:0042797]	nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]	RNA polymerase III general transcription initiation factor activity [GO:0000995]	nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; 5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; tRNA transcription by RNA polymerase III [GO:0042797]	SUBCELLULAR LOCATION: Nucleus.
Q8WUA7	reviewed	TB22A_HUMAN	TBC1 domain family member 22A	TBC1D22A C22orf4	Homo sapiens (Human)	517	FUNCTION: May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}.				14-3-3 protein binding [GO:0071889]; GTPase activator activity [GO:0005096]; protein homodimerization activity [GO:0042803]	14-3-3 protein binding [GO:0071889]; GTPase activator activity [GO:0005096]; protein homodimerization activity [GO:0042803]	
Q8WUA8	reviewed	TSK_HUMAN	Tsukushi (E2-induced gene 4 protein) (Leucine-rich repeat-containing protein 54)	TSKU E2IG4 LRRC54 TSK UNQ850/PRO1788	Homo sapiens (Human)	353	FUNCTION: Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis. {ECO:0000250|UniProtKB:Q8CBR6}.	MISCELLANEOUS: This factor is named 'Tsukushi' because its expression pattern in chick embryos is similar to the shape of the Japanese horsetail plant, tsukushi. {ECO:0000250|UniProtKB:Q65Z91}.	anterior commissure morphogenesis [GO:0021960]; bone growth [GO:0098868]; camera-type eye development [GO:0043010]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; ciliary body morphogenesis [GO:0061073]; corpus callosum morphogenesis [GO:0021540]; energy homeostasis [GO:0097009]; growth plate cartilage chondrocyte development [GO:0003431]; hippocampus development [GO:0021766]; inner ear receptor cell stereocilium organization [GO:0060122]; lateral ventricle development [GO:0021670]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transforming growth factor beta1 production [GO:0032911]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of hair cycle [GO:0042635]; regulation of gene expression [GO:0010468]; wound healing [GO:0042060]	extracellular space [GO:0005615]	transforming growth factor beta binding [GO:0050431]	extracellular space [GO:0005615]; transforming growth factor beta binding [GO:0050431]; anterior commissure morphogenesis [GO:0021960]; bone growth [GO:0098868]; camera-type eye development [GO:0043010]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; ciliary body morphogenesis [GO:0061073]; corpus callosum morphogenesis [GO:0021540]; energy homeostasis [GO:0097009]; growth plate cartilage chondrocyte development [GO:0003431]; hippocampus development [GO:0021766]; inner ear receptor cell stereocilium organization [GO:0060122]; lateral ventricle development [GO:0021670]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transforming growth factor beta1 production [GO:0032911]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of hair cycle [GO:0042635]; regulation of gene expression [GO:0010468]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8CBR6}.
Q8WUB8	reviewed	PHF10_HUMAN	PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135)	PHF10 BAF45A	Homo sapiens (Human)	498	FUNCTION: Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}.		chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; kinetochore [GO:0000776]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	histone acetyltransferase activity [GO:0004402]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; kinetochore [GO:0000776]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; histone acetyltransferase activity [GO:0004402]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8WUD1	reviewed	RAB2B_HUMAN	Ras-related protein Rab-2B (EC 3.6.5.2)	RAB2B	Homo sapiens (Human)	216	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). {ECO:0000250|UniProtKB:P59279, ECO:0000305|PubMed:26209634}.		defense response to virus [GO:0051607]; Golgi organization [GO:0007030]; innate immune response [GO:0045087]; positive regulation of exocytosis [GO:0045921]; positive regulation of type I interferon production [GO:0032481]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	acrosomal vesicle [GO:0001669]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	acrosomal vesicle [GO:0001669]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; defense response to virus [GO:0051607]; Golgi organization [GO:0007030]; innate immune response [GO:0045087]; positive regulation of exocytosis [GO:0045921]; positive regulation of type I interferon production [GO:0032481]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}; Cytoplasmic side {ECO:0000250|UniProtKB:P59279}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P59279}. Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid. {ECO:0000250|UniProtKB:P59279}.
Q8WUD6	reviewed	CHPT1_HUMAN	Cholinephosphotransferase 1 (hCPT1) (EC 2.7.8.2) (AAPT1-like protein) (Diacylglycerol cholinephosphotransferase 1)	CHPT1 CPT1 MSTP022	Homo sapiens (Human)	406	FUNCTION: Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the formation and maintenance of vesicular membranes. {ECO:0000269|PubMed:10893425}.		CDP-choline pathway [GO:0006657]; lipid metabolic process [GO:0006629]; phosphatidylcholine biosynthetic process [GO:0006656]; platelet activating factor biosynthetic process [GO:0006663]; regulation of cell growth [GO:0001558]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	diacylglycerol binding [GO:0019992]; diacylglycerol cholinephosphotransferase activity [GO:0004142]; metal ion binding [GO:0046872]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; diacylglycerol binding [GO:0019992]; diacylglycerol cholinephosphotransferase activity [GO:0004142]; metal ion binding [GO:0046872]; CDP-choline pathway [GO:0006657]; lipid metabolic process [GO:0006629]; phosphatidylcholine biosynthetic process [GO:0006656]; platelet activating factor biosynthetic process [GO:0006663]; regulation of cell growth [GO:0001558]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12221122}; Multi-pass membrane protein {ECO:0000269|PubMed:12221122}.
Q8WUE5	reviewed	CT55_HUMAN	Cancer/testis antigen 55 (Tumor antigen BJ-HCC-20)	CT55 CXorf48	Homo sapiens (Human)	264	FUNCTION: Plays a role in spermatogenesis, possibly acting in the regulation of the autophagy pathway. {ECO:0000269|PubMed:36481789}.		spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]		acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36481789}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:36481789}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:36481789}. Note=Mainly observed in the cytoplasm of spermatocyte and spermatogonia, and also found in acrosome or flagellum in early and late spermatids. {ECO:0000269|PubMed:36481789}.
Q8WUF5	reviewed	IASPP_HUMAN	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein)	PPP1R13L IASPP NKIP1 PPP1R13BL RAI	Homo sapiens (Human)	828	FUNCTION: Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900}.		apoptotic process [GO:0006915]; cardiac muscle contraction [GO:0060048]; cardiac right ventricle morphogenesis [GO:0003215]; embryonic camera-type eye development [GO:0031076]; hair cycle [GO:0042633]; multicellular organism growth [GO:0035264]; multicellular organismal-level homeostasis [GO:0048871]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell differentiation [GO:0045597]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; ventricular cardiac muscle tissue development [GO:0003229]	cell junction [GO:0030054]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]	cell junction [GO:0030054]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]; apoptotic process [GO:0006915]; cardiac muscle contraction [GO:0060048]; cardiac right ventricle morphogenesis [GO:0003215]; embryonic camera-type eye development [GO:0031076]; hair cycle [GO:0042633]; multicellular organism growth [GO:0035264]; multicellular organismal-level homeostasis [GO:0048871]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell differentiation [GO:0045597]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; ventricular cardiac muscle tissue development [GO:0003229]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15489900}. Nucleus {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:15489900}. Note=Predominantly cytoplasmic but also nuclear. {ECO:0000269|PubMed:15489900}.
Q8WUG5	reviewed	S22AH_HUMAN	Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor) (Neutrophil gelatinase-associated lipocalin receptor) (NgalR)	SLC22A17 BOCT BOIT	Homo sapiens (Human)	538	FUNCTION: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). {ECO:0000250}.		intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; siderophore transport [GO:0015891]	organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]	transmembrane signaling receptor activity [GO:0004888]; transmembrane transporter activity [GO:0022857]	organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]; transmembrane signaling receptor activity [GO:0004888]; transmembrane transporter activity [GO:0022857]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; siderophore transport [GO:0015891]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17253959}; Multi-pass membrane protein {ECO:0000269|PubMed:17253959}. Vacuole membrane {ECO:0000269|PubMed:17253959}; Multi-pass membrane protein {ECO:0000269|PubMed:17253959}. Note=Upon LCN2-binding, it is internalized.
Q8WUH2	reviewed	TGFA1_HUMAN	Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1)	TGFBRAP1	Homo sapiens (Human)	860	FUNCTION: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. {ECO:0000269|PubMed:11278302, ECO:0000269|PubMed:9545258}.; FUNCTION: Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (PubMed:25266290). {ECO:0000269|PubMed:25266290, ECO:0000305|PubMed:25266290}.		autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; regulation of DNA-templated transcription [GO:0006355]; regulation of SNARE complex assembly [GO:0035542]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]	CORVET complex [GO:0033263]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]	CORVET complex [GO:0033263]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]; autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; regulation of DNA-templated transcription [GO:0006355]; regulation of SNARE complex assembly [GO:0035542]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11278302}. Early endosome {ECO:0000269|PubMed:25266290}. Note=Colocalizes with TGF-beta receptors in the absence of signaling.
Q8WUI4	reviewed	HDAC7_HUMAN	Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a)	HDAC7 HDAC7A	Homo sapiens (Human)	952	FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758}.	MISCELLANEOUS: Its activity is inhibited by Trichostatin A (TSA), a known histone deacetylase inhibitor. {ECO:0000250}.	cell-cell junction assembly [GO:0007043]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; protein deacetylation [GO:0006476]; protein sumoylation [GO:0016925]; vasculogenesis [GO:0001570]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	14-3-3 protein binding [GO:0071889]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein lysine deacetylase activity [GO:0033558]; SUMO transferase activity [GO:0019789]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 14-3-3 protein binding [GO:0071889]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein lysine deacetylase activity [GO:0033558]; SUMO transferase activity [GO:0019789]; transcription corepressor activity [GO:0003714]; cell-cell junction assembly [GO:0007043]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; protein deacetylation [GO:0006476]; protein sumoylation [GO:0016925]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
Q8WUJ0	reviewed	STYX_HUMAN	Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)	STYX	Homo sapiens (Human)	223	FUNCTION: Catalytically inactive phosphatase (PubMed:23847209). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894). Plays a role in spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q60969, ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}.		dephosphorylation [GO:0016311]; MAPK export from nucleus [GO:0045204]; negative regulation of protein binding [GO:0032091]; negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process [GO:0062026]; regulation of ERK1 and ERK2 cascade [GO:0070372]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	F-box domain binding [GO:1990444]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; pseudophosphatase activity [GO:0001691]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; F-box domain binding [GO:1990444]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; pseudophosphatase activity [GO:0001691]; dephosphorylation [GO:0016311]; MAPK export from nucleus [GO:0045204]; negative regulation of protein binding [GO:0032091]; negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process [GO:0062026]; regulation of ERK1 and ERK2 cascade [GO:0070372]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}. Cytoplasm, cytosol {ECO:0000269|PubMed:23847209}. Note=Predominantly localizes to the nucleus. {ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}.
Q8WUJ3	reviewed	CEMIP_HUMAN	Cell migration-inducing and hyaluronan-binding protein (EC 3.2.1.35) (Hyaluronan binding protein involved in hyaluronan depolymerization)	CEMIP HYBID KIAA1199	Homo sapiens (Human)	1361	FUNCTION: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing. {ECO:0000269|PubMed:23509262, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:24269685}.		hyaluronan biosynthetic process [GO:0030213]; hyaluronan catabolic process [GO:0030214]; positive regulation of cell migration [GO:0030335]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; sensory perception of sound [GO:0007605]	clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	clathrin heavy chain binding [GO:0032050]; ER retention sequence binding [GO:0046923]; hyaluronic acid binding [GO:0005540]; hyalurononglucosaminidase activity [GO:0004415]	clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; clathrin heavy chain binding [GO:0032050]; ER retention sequence binding [GO:0046923]; hyaluronic acid binding [GO:0005540]; hyalurononglucosaminidase activity [GO:0004415]; hyaluronan biosynthetic process [GO:0030213]; hyaluronan catabolic process [GO:0030214]; positive regulation of cell migration [GO:0030335]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.
Q8WUK0	reviewed	PTPM1_HUMAN	Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC 3.1.3.27) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase) (Protein-tyrosine phosphatase mitochondrial 1) (EC 3.1.3.16, EC 3.1.3.48)	PTPMT1 MOSP PLIP PNAS-129	Homo sapiens (Human)	201	FUNCTION: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (PubMed:24709986). {ECO:0000250|UniProtKB:P0C089, ECO:0000250|UniProtKB:Q66GT5, ECO:0000269|PubMed:24709986}.		cardiolipin biosynthetic process [GO:0032049]; dephosphorylation [GO:0016311]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	myosin phosphatase activity [GO:0017018]; phosphatidylglycerophosphatase activity [GO:0008962]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; myosin phosphatase activity [GO:0017018]; phosphatidylglycerophosphatase activity [GO:0008962]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cardiolipin biosynthetic process [GO:0032049]; dephosphorylation [GO:0016311]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P0C089}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C089}; Matrix side {ECO:0000250|UniProtKB:P0C089}.
Q8WUM0	reviewed	NU133_HUMAN	Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133)	NUP133	Homo sapiens (Human)	1156	FUNCTION: Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}.		mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; paraxial mesoderm development [GO:0048339]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein import into nucleus [GO:0006606]; somite development [GO:0061053]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]	cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; structural constituent of nuclear pore [GO:0017056]; mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; paraxial mesoderm development [GO:0048339]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein import into nucleus [GO:0006606]; somite development [GO:0061053]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:11684705}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11564755}. Note=Located on both the cytoplasmic and nuclear sides of the nuclear pore (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:11684705}.
Q8WUM4	reviewed	PDC6I_HUMAN	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)	PDCD6IP AIP1 ALIX KIAA1375	Homo sapiens (Human)	868	FUNCTION: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}.		actomyosin contractile ring assembly [GO:0000915]; apoptotic process [GO:0006915]; bicellular tight junction assembly [GO:0070830]; extracellular exosome biogenesis [GO:0097734]; macroautophagy [GO:0016236]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; multivesicular body assembly [GO:0036258]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of extracellular exosome assembly [GO:1903551]; regulation of membrane permeability [GO:0090559]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]	actomyosin [GO:0042641]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; melanosome [GO:0042470]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]	calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; proteinase activated receptor binding [GO:0031871]	actomyosin [GO:0042641]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; melanosome [GO:0042470]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; proteinase activated receptor binding [GO:0031871]; actomyosin contractile ring assembly [GO:0000915]; apoptotic process [GO:0006915]; bicellular tight junction assembly [GO:0070830]; extracellular exosome biogenesis [GO:0097734]; macroautophagy [GO:0016236]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; multivesicular body assembly [GO:0036258]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of extracellular exosome assembly [GO:1903551]; regulation of membrane permeability [GO:0090559]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9QZA2}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893}. Secreted, extracellular exosome {ECO:0000269|PubMed:22660413}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9WU78}. Midbody, Midbody ring {ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 at centrosomes of non-dividing cells. Component of the actomyosin-tight junction complex (By similarity). PDCD6IP targeting to the midbody requires the interaction with CEP55 (PubMed:18641129). {ECO:0000250|UniProtKB:Q9QZA2, ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129}.
Q8WUM9	reviewed	S20A1_HUMAN	Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1)	SLC20A1 GLVR1 PIT1	Homo sapiens (Human)	679	FUNCTION: Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:7929240, PubMed:8041748, PubMed:19726692, PubMed:17494632, PubMed:16790504). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}.		biomineral tissue development [GO:0031214]; cell population proliferation [GO:0008283]; monoatomic ion transport [GO:0006811]; phosphate ion transmembrane transport [GO:0035435]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	membrane [GO:0016020]; plasma membrane [GO:0005886]	high-affinity inorganic phosphate:sodium symporter activity [GO:0005316]; inorganic phosphate transmembrane transporter activity [GO:0005315]; signaling receptor activity [GO:0038023]; sodium:phosphate symporter activity [GO:0005436]	membrane [GO:0016020]; plasma membrane [GO:0005886]; high-affinity inorganic phosphate:sodium symporter activity [GO:0005316]; inorganic phosphate transmembrane transporter activity [GO:0005315]; signaling receptor activity [GO:0038023]; sodium:phosphate symporter activity [GO:0005436]; biomineral tissue development [GO:0031214]; cell population proliferation [GO:0008283]; monoatomic ion transport [GO:0006811]; phosphate ion transmembrane transport [GO:0035435]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19726692}; Multi-pass membrane protein {ECO:0000255}.
Q8WUP2	reviewed	FBLI1_HUMAN	Filamin-binding LIM protein 1 (FBLP-1) (Migfilin) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein)	FBLIM1 FBLP1	Homo sapiens (Human)	373	FUNCTION: Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455, ECO:0000269|PubMed:19074766}.	MISCELLANEOUS: [Isoform 2]: May be due to competing donor splice site. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to exon skipping. {ECO:0000305}.	cell-cell adhesion [GO:0098609]; regulation of cell shape [GO:0008360]; regulation of integrin activation [GO:0033623]	cell junction [GO:0030054]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; focal adhesion [GO:0005925]; stress fiber [GO:0001725]	filamin binding [GO:0031005]; metal ion binding [GO:0046872]	cell junction [GO:0030054]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; focal adhesion [GO:0005925]; stress fiber [GO:0001725]; filamin binding [GO:0031005]; metal ion binding [GO:0046872]; cell-cell adhesion [GO:0098609]; regulation of cell shape [GO:0008360]; regulation of integrin activation [GO:0033623]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455}. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites (PubMed:12679033, PubMed:18829455). Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2 (PubMed:12679033). Isoform 2 is localized at actin stress fibers (PubMed:12496242). {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455}.
Q8WUQ7	reviewed	CATIN_HUMAN	Splicing factor Cactin (Renal carcinoma antigen NY-REN-24)	CACTIN C19orf29	Homo sapiens (Human)	758	FUNCTION: Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (PubMed:28062851). Required for the splicing of CDCA5/Sororin, a regulator of sister chromatid cohesion (PubMed:28062851). Involved in the regulation of innate immune response (PubMed:20829348). Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (PubMed:20829348, PubMed:26363554). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (PubMed:20829348, PubMed:26363554). {ECO:0000269|PubMed:20829348, ECO:0000269|PubMed:26363554, ECO:0000269|PubMed:28062851}.	MISCELLANEOUS: Antigen recognized by autologous antibody in patients with renal-cell carcinoma.; MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.	cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; innate immune response [GO:0045087]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; innate immune response [GO:0045087]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20829348, ECO:0000269|PubMed:26363554, ECO:0000269|PubMed:28062851}. Cytoplasm, cytosol {ECO:0000269|PubMed:26363554}. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus. {ECO:0000269|PubMed:20829348}.
Q8WUU4	reviewed	ZN296_HUMAN	Zinc finger protein 296 (ZFP296) (Zinc finger protein 342)	ZNF296 ZNF342	Homo sapiens (Human)	475	FUNCTION: May be a transcriptional corepressor with KLF4. {ECO:0000250|UniProtKB:E9Q6W4}.		negative regulation of dendrite development [GO:2000171]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of dendrite development [GO:2000171]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:E9Q6W4}.
Q8WUU5	reviewed	GATD1_HUMAN	GATA zinc finger domain-containing protein 1 (Ocular development-associated gene protein)	GATAD1 ODAG	Homo sapiens (Human)	269	FUNCTION: Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). {ECO:0000269|PubMed:20850016}.		chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; regulation of DNA-templated transcription [GO:0006355]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21965549}.
Q8WUU8	reviewed	TM174_HUMAN	Transmembrane protein 174	TMEM174	Homo sapiens (Human)	243	FUNCTION: Regulator of plasma phosphate homeostasis. Decreases serum inorganic phosphate (Pi) uptake by regulating the sodium-phosphate cotransporter SLC34A1 trafficking by PTH and FGF23 in the kidney. {ECO:0000250|UniProtKB:Q9DCX7}.		phosphate ion homeostasis [GO:0055062]	apical plasma membrane [GO:0016324]; endoplasmic reticulum membrane [GO:0005789]		apical plasma membrane [GO:0016324]; endoplasmic reticulum membrane [GO:0005789]; phosphate ion homeostasis [GO:0055062]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20331980}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:35459732}; Multi-pass membrane protein {ECO:0000255}.
Q8WUW1	reviewed	BRK1_HUMAN	Protein BRICK1 (BRK1)	BRK1 C3orf10 HSPC300 MDS027	Homo sapiens (Human)	75	FUNCTION: Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q91VR8, ECO:0000269|PubMed:18560548}.		actin filament organization [GO:0007015]; cell motility [GO:0048870]; fibroblast proliferation [GO:0048144]; in utero embryonic development [GO:0001701]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of protein-containing complex assembly [GO:0031334]; Rac protein signal transduction [GO:0016601]; regulation of actin polymerization or depolymerization [GO:0008064]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; SCAR complex [GO:0031209]	identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; SCAR complex [GO:0031209]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; actin filament organization [GO:0007015]; cell motility [GO:0048870]; fibroblast proliferation [GO:0048144]; in utero embryonic development [GO:0001701]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of protein-containing complex assembly [GO:0031334]; Rac protein signal transduction [GO:0016601]; regulation of actin polymerization or depolymerization [GO:0008064]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q8WUX1	reviewed	S38A5_HUMAN	Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2)	SLC38A5 JM24 SN2 SNAT5 PP7194	Homo sapiens (Human)	472	FUNCTION: Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11243884). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate-glutamine cycle (By similarity). The transport activity is pH sensitive and Li(+) tolerant (PubMed:11243884). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity). {ECO:0000250|UniProtKB:A2VCW5, ECO:0000250|UniProtKB:Q3U1J0, ECO:0000269|PubMed:11243884}.		amino acid export across plasma membrane [GO:0032973]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; asparagine transmembrane transport [GO:1903713]; glutamine transport [GO:0006868]; glycine transport [GO:0015816]; L-alanine transmembrane transport [GO:1904557]; L-glutamine import across plasma membrane [GO:1903803]; L-histidine transmembrane transport [GO:0089709]; L-serine import across plasma membrane [GO:1903812]; L-serine transport [GO:0015825]; neutral amino acid transport [GO:0015804]; serine transport [GO:0032329]; transport across blood-brain barrier [GO:0150104]	plasma membrane [GO:0005886]	alanine transmembrane transporter activity [GO:0022858]; amino acid transmembrane transporter activity [GO:0015171]; glycine transmembrane transporter activity [GO:0015187]; L-asparagine transmembrane transporter activity [GO:0015182]; L-glutamine transmembrane transporter activity [GO:0015186]; L-glutamine, sodium:proton antiporter activity [GO:0140830]; L-histidine transmembrane transporter activity [GO:0005290]; L-serine transmembrane transporter activity [GO:0015194]; neutral amino acid, sodium:proton antiporter activity [GO:0140893]; serine transmembrane transporter activity [GO:0022889]	plasma membrane [GO:0005886]; alanine transmembrane transporter activity [GO:0022858]; amino acid transmembrane transporter activity [GO:0015171]; glycine transmembrane transporter activity [GO:0015187]; L-asparagine transmembrane transporter activity [GO:0015182]; L-glutamine transmembrane transporter activity [GO:0015186]; L-glutamine, sodium:proton antiporter activity [GO:0140830]; L-histidine transmembrane transporter activity [GO:0005290]; L-serine transmembrane transporter activity [GO:0015194]; neutral amino acid, sodium:proton antiporter activity [GO:0140893]; serine transmembrane transporter activity [GO:0022889]; amino acid export across plasma membrane [GO:0032973]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; asparagine transmembrane transport [GO:1903713]; glutamine transport [GO:0006868]; glycine transport [GO:0015816]; L-alanine transmembrane transport [GO:1904557]; L-glutamine import across plasma membrane [GO:1903803]; L-histidine transmembrane transport [GO:0089709]; L-serine import across plasma membrane [GO:1903812]; L-serine transport [GO:0015825]; neutral amino acid transport [GO:0015804]; serine transport [GO:0032329]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A2VCW5}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at astroglial membrane. {ECO:0000250|UniProtKB:A2VCW5}.
Q8WUX9	reviewed	CHMP7_HUMAN	Charged multivesicular body protein 7 (Chromatin-modifying protein 7)	CHMP7	Homo sapiens (Human)	453	FUNCTION: ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:28242692, PubMed:26040712). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.		autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; ESCRT III complex disassembly [GO:1904903]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein localization to chromatin [GO:0071168]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; ESCRT III complex disassembly [GO:1904903]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein localization to chromatin [GO:0071168]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16856878}. Nucleus envelope {ECO:0000269|PubMed:26040712}. Nucleus envelope {ECO:0000269|PubMed:28242692}. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area (PubMed:16856878). Localizes to the reforming nuclear envelope on chromatin disks during late anaphase (PubMed:26040712, PubMed:28242692). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.
Q8WUY3	reviewed	PRUN2_HUMAN	Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1)	PRUNE2 BMCC1 BNIPXL C9orf65 KIAA0367	Homo sapiens (Human)	3088	FUNCTION: May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}.	MISCELLANEOUS: PRUNE2/BMCC1 and PCA3, one of the most prostate cancer specific markers are overlapping genes in reverse orientation. However, they do not appear to be coregulated.	apoptotic process [GO:0006915]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	metal ion binding [GO:0046872]; pyrophosphatase activity [GO:0016462]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; metal ion binding [GO:0046872]; pyrophosphatase activity [GO:0016462]; apoptotic process [GO:0006915]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16288218}.
Q8WV16	reviewed	DCAF4_HUMAN	DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A)	DCAF4 WDR21 WDR21A	Homo sapiens (Human)	495	FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.		protein ubiquitination [GO:0016567]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654]; protein ubiquitination [GO:0016567]	
Q8WV19	reviewed	SFT2A_HUMAN	Vesicle transport protein SFT2A (SFT2 domain-containing protein 1) (pRGR1)	SFT2D1 C6orf83	Homo sapiens (Human)	159	FUNCTION: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. {ECO:0000250|UniProtKB:P38166}.		protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	membrane [GO:0016020]		membrane [GO:0016020]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q8WV22	reviewed	NSE1_HUMAN	Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 2.3.2.27)	NSMCE1 HSPC333 HSPC337	Homo sapiens (Human)	266	FUNCTION: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair (PubMed:29225034, PubMed:20864041). NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair (PubMed:18086888). MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors (PubMed:29225034). {ECO:0000269|PubMed:18086888, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:29225034}.		chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	chromosome, telomeric region [GO:0000781]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]	metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	chromosome, telomeric region [GO:0000781]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000305|PubMed:18086888}.
Q8WV24	reviewed	PHLA1_HUMAN	Pleckstrin homology-like domain family A member 1 (Apoptosis-associated nuclear protein) (Proline- and glutamine-rich protein) (PQ-rich protein) (PQR protein) (Proline- and histidine-rich protein) (T-cell death-associated gene 51 protein)	PHLDA1 PHRIP TDAG51	Homo sapiens (Human)	401	FUNCTION: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. {ECO:0000269|PubMed:11369516, ECO:0000269|PubMed:12738777}.		apoptotic process [GO:0006915]; FasL biosynthetic process [GO:0045210]; positive regulation of apoptotic process [GO:0043065]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	phosphatidylinositol phosphate binding [GO:1901981]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phosphatidylinositol phosphate binding [GO:1901981]; apoptotic process [GO:0006915]; FasL biosynthetic process [GO:0045210]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11369516}. Cytoplasmic vesicle {ECO:0000269|PubMed:12738777}. Nucleus, nucleolus {ECO:0000269|PubMed:11369516}. Note=Colocalizes with intracellular vesicles. {ECO:0000269|PubMed:12738777}.
Q8WV28	reviewed	BLNK_HUMAN	B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)	BLNK BASH SLP65	Homo sapiens (Human)	456	FUNCTION: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}.		B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; positive regulation of gene expression [GO:0010628]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]; lipid binding [GO:0008289]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; lipid binding [GO:0008289]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; positive regulation of gene expression [GO:0010628]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9697839}. Cell membrane {ECO:0000269|PubMed:9697839}. Note=BCR activation results in the translocation to membrane fraction.
Q8WV37	reviewed	ZN480_HUMAN	Zinc finger protein 480	ZNF480	Homo sapiens (Human)	535	FUNCTION: Involved in transcriptional regulation as an activator. {ECO:0000269|PubMed:15219843}.		regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15219843}.
Q8WV41	reviewed	SNX33_HUMAN	Sorting nexin-33 (SH3 and PX domain-containing protein 3)	SNX33 SH3PX3 SH3PXD3C SNX30	Homo sapiens (Human)	574	FUNCTION: Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:18419754, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:20964629, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.		cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; macropinocytosis [GO:0044351]; mitotic cytokinesis [GO:0000281]; negative regulation of endocytosis [GO:0045806]; negative regulation of protein localization to cell surface [GO:2000009]; plasma membrane tubulation [GO:0097320]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein localization to cell surface [GO:2000010]; protein import [GO:0017038]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; macropinocytosis [GO:0044351]; mitotic cytokinesis [GO:0000281]; negative regulation of endocytosis [GO:0045806]; negative regulation of protein localization to cell surface [GO:2000009]; plasma membrane tubulation [GO:0097320]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein localization to cell surface [GO:2000010]; protein import [GO:0017038]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941). {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:21048941}.
Q8WV44	reviewed	TRI41_HUMAN	E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41)	TRIM41 RINCK	Homo sapiens (Human)	630	FUNCTION: E3 ligase that plays essential roles in innate antiviral response (PubMed:28169297, PubMed:29760876, PubMed:29899090, PubMed:31979016). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (PubMed:29899090, PubMed:31979016, PubMed:28169297). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (PubMed:29760876). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:17893151, PubMed:33378676). {ECO:0000250|UniProtKB:Q5NCC3, ECO:0000269|PubMed:17893151, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:29760876, ECO:0000269|PubMed:29899090, ECO:0000269|PubMed:31979016, ECO:0000269|PubMed:33378676}.		cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; defense response to virus [GO:0051607]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleolus [GO:0005730]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; defense response to virus [GO:0051607]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16022281, ECO:0000269|PubMed:29899090, ECO:0000269|PubMed:31979016}. Nucleus {ECO:0000269|PubMed:16022281, ECO:0000269|PubMed:29899090, ECO:0000269|PubMed:31979016}.
Q8WV74	reviewed	NUDT8_HUMAN	Mitochondrial coenzyme A diphosphatase NUDT8 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 8) (Nudix motif 8)	NUDT8	Homo sapiens (Human)	236	FUNCTION: Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products (By similarity). Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). {ECO:0000250|UniProtKB:Q9CR24}.		acetyl-CoA catabolic process [GO:0046356]; butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; propionyl-CoA catabolic process [GO:1902859]; succinyl-CoA catabolic process [GO:1901289]	mitochondrion [GO:0005739]	acyl-coenzyme A diphosphatase activity [GO:0106399]; CoA pyrophosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]	mitochondrion [GO:0005739]; acyl-coenzyme A diphosphatase activity [GO:0106399]; CoA pyrophosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; acetyl-CoA catabolic process [GO:0046356]; butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; propionyl-CoA catabolic process [GO:1902859]; succinyl-CoA catabolic process [GO:1901289]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9CR24}.
Q8WV92	reviewed	MITD1_HUMAN	MIT domain-containing protein 1	MITD1	Homo sapiens (Human)	249	FUNCTION: Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex. {ECO:0000269|PubMed:23015756, ECO:0000269|PubMed:23045692}.		midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; negative regulation of protein binding [GO:0032091]	extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; midbody [GO:0030496]	identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]	extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; midbody [GO:0030496]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; negative regulation of protein binding [GO:0032091]	SUBCELLULAR LOCATION: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides.
Q8WV93	reviewed	AFG1L_HUMAN	AFG1-like ATPase (Lactation elevated protein 1) (EC 3.6.-.-) (Protein AFG1 homolog)	AFG1L AFG1 LACE1	Homo sapiens (Human)	481	FUNCTION: Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain (PubMed:26759378, PubMed:27323408). Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress (PubMed:27323408). {ECO:0000269|PubMed:26759378, ECO:0000269|PubMed:27323408}.		mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial protein catabolic process [GO:0035694]; mitochondrion organization [GO:0007005]	cytoplasm [GO:0005737]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	cytoplasm [GO:0005737]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial protein catabolic process [GO:0035694]; mitochondrion organization [GO:0007005]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:26759378}.
Q8WV99	reviewed	ZFN2B_HUMAN	AN1-type zinc finger protein 2B (Arsenite-inducible RNA-associated protein-like protein) (AIRAP-like protein)	ZFAND2B AIRAPL	Homo sapiens (Human)	257	FUNCTION: Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q91X58, ECO:0000269|PubMed:26692333}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein targeting to ER [GO:0045047]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; proteasome complex [GO:0000502]	K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; proteasome complex [GO:0000502]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein targeting to ER [GO:0045047]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91X58}; Lipid-anchor {ECO:0000250|UniProtKB:Q91X58}.
Q8WVB3	reviewed	HEXD_HUMAN	Hexosaminidase D (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase D) (Hexosaminidase domain-containing protein) (N-acetyl-beta-galactosaminidase)	HEXD HEXDC	Homo sapiens (Human)	486	FUNCTION: Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (PubMed:27149221). {ECO:0000269|PubMed:19040401, ECO:0000269|PubMed:23099419, ECO:0000269|PubMed:27149221}.		carbohydrate metabolic process [GO:0005975]	cytoplasm [GO:0005737]; extracellular vesicle [GO:1903561]; nucleus [GO:0005634]	beta-N-acetylhexosaminidase activity [GO:0004563]; hexosaminidase activity [GO:0015929]; N-acetyl-beta-D-galactosaminidase activity [GO:0102148]	cytoplasm [GO:0005737]; extracellular vesicle [GO:1903561]; nucleus [GO:0005634]; beta-N-acetylhexosaminidase activity [GO:0004563]; hexosaminidase activity [GO:0015929]; N-acetyl-beta-D-galactosaminidase activity [GO:0102148]; carbohydrate metabolic process [GO:0005975]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3U4H6}. Nucleus {ECO:0000250|UniProtKB:Q3U4H6}. Extracellular vesicle {ECO:0000269|PubMed:23099419}.
Q8WVB6	reviewed	CTF18_HUMAN	Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12)	CHTF18 C16orf41 CTF18	Homo sapiens (Human)	975	FUNCTION: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166, ECO:0000269|PubMed:20227374}.		cell cycle [GO:0007049]; DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	Ctf18 RFC-like complex [GO:0031390]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]	Ctf18 RFC-like complex [GO:0031390]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; cell cycle [GO:0007049]; DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12766176}. Note=Associates with chromatin during S phase.
Q8WVC0	reviewed	LEO1_HUMAN	RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein)	LEO1 RDL	Homo sapiens (Human)	666	FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}.		endodermal cell fate commitment [GO:0001711]; mRNA polyadenylation [GO:0006378]; negative regulation of myeloid cell differentiation [GO:0045638]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055]	Cdc73/Paf1 complex [GO:0016593]; centrosome [GO:0005813]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]	Cdc73/Paf1 complex [GO:0016593]; centrosome [GO:0005813]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; endodermal cell fate commitment [GO:0001711]; mRNA polyadenylation [GO:0006378]; negative regulation of myeloid cell differentiation [GO:0045638]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15791002}.
Q8WVD3	reviewed	RN138_HUMAN	E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)	RNF138 NARF HSD-4 HSD4	Homo sapiens (Human)	245	FUNCTION: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285). {ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}.		cellular response to leukemia inhibitory factor [GO:1990830]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; double-strand break repair via homologous recombination [GO:0000724]; protein ubiquitination [GO:0016567]; Wnt signaling pathway [GO:0016055]	nucleus [GO:0005634]; site of double-strand break [GO:0035861]	metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase activity [GO:0061630]	nucleus [GO:0005634]; site of double-strand break [GO:0035861]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase activity [GO:0061630]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; double-strand break repair via homologous recombination [GO:0000724]; protein ubiquitination [GO:0016567]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}. Note=Recruited at DNA damage sites (PubMed:26502055). Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057). {ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}.
Q8WVD5	reviewed	RN141_HUMAN	RING finger protein 141 (Zinc finger protein 230)	RNF141 ZNF230	Homo sapiens (Human)	230	FUNCTION: May be involved in spermatogenesis. {ECO:0000269|PubMed:11672448}.		protein autoubiquitination [GO:0051865]; regulation of DNA-templated transcription [GO:0006355]	membrane [GO:0016020]	metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]	membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; protein autoubiquitination [GO:0051865]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Q8WVE7	reviewed	T170A_HUMAN	Transmembrane protein 170A	TMEM170A TMEM170	Homo sapiens (Human)	144	FUNCTION: Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). {ECO:0000269|PubMed:26906412}.		endoplasmic reticulum tubular network organization [GO:0071786]; nuclear envelope organization [GO:0006998]; nuclear pore complex assembly [GO:0051292]	endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]		endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; endoplasmic reticulum tubular network organization [GO:0071786]; nuclear envelope organization [GO:0006998]; nuclear pore complex assembly [GO:0051292]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26906412}; Multi-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:26906412}.
Q8WVF1	reviewed	OSCP1_HUMAN	Protein OSCP1 (hOSCP1) (Organic solute transport protein 1) (Oxidored-nitro domain-containing protein 1)	OSCP1 C1orf102 NOR1	Homo sapiens (Human)	389	FUNCTION: May be involved in drug clearance in the placenta. {ECO:0000269|PubMed:16006562}.	MISCELLANEOUS: May be involved in the development and/or progression of nosopharyngeal carcinoma.	xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	transmembrane transporter activity [GO:0022857]	basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	SUBCELLULAR LOCATION: Basal cell membrane. Note=Syncytiotrophoblast in placenta.
Q8WVJ2	reviewed	NUDC2_HUMAN	NudC domain-containing protein 2	NUDCD2	Homo sapiens (Human)	157	FUNCTION: May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. {ECO:0000269|PubMed:20133715}.		protein folding [GO:0006457]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]	unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20133715}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20133715}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20133715}. Note=Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis.
Q8WVJ9	reviewed	TWST2_HUMAN	Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1)	TWIST2 BHLHA39 DERMO1	Homo sapiens (Human)	160	FUNCTION: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. {ECO:0000250, ECO:0000269|PubMed:11062344}.		cell differentiation [GO:0030154]; developmental process [GO:0032502]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of cell migration [GO:0030335]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cell differentiation [GO:0030154]; developmental process [GO:0032502]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of cell migration [GO:0030335]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11062344}. Cytoplasm {ECO:0000269|PubMed:11062344}. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
Q8WVK2	reviewed	SNR27_HUMAN	U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (Nucleic acid-binding protein RY-1) (U4/U6.U5 tri-snRNP-associated 27 kDa protein) (27K) (U4/U6.U5 tri-snRNP-associated protein 3)	SNRNP27	Homo sapiens (Human)	155	FUNCTION: May play a role in mRNA splicing.		mRNA splicing, via spliceosome [GO:0000398]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	nucleic acid binding [GO:0003676]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; nucleic acid binding [GO:0003676]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8WVK7	reviewed	SKA2_HUMAN	Spindle and kinetochore-associated protein 2 (Protein FAM33A)	SKA2 FAM33A	Homo sapiens (Human)	121	FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:23085020}.		cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; regulation of microtubule polymerization or depolymerization [GO:0031110]	cytosol [GO:0005829]; kinetochore [GO:0000776]; outer kinetochore [GO:0000940]; spindle microtubule [GO:0005876]	microtubule binding [GO:0008017]	cytosol [GO:0005829]; kinetochore [GO:0000776]; outer kinetochore [GO:0000940]; spindle microtubule [GO:0005876]; microtubule binding [GO:0008017]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; regulation of microtubule polymerization or depolymerization [GO:0031110]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083}.
Q8WVM0	reviewed	TFB1M_HUMAN	Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (h-mtTFB) (h-mtTFB1) (hTFB1M) (mtTFB1) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1)	TFB1M CGI-75	Homo sapiens (Human)	346	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. {ECO:0000269|PubMed:11809803, ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151}.		rRNA methylation [GO:0031167]; rRNA modification [GO:0000154]; transcription initiation at mitochondrial promoter [GO:0006391]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]	DNA binding [GO:0003677]; mitochondrial transcription factor activity [GO:0034246]; RNA binding [GO:0003723]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; DNA binding [GO:0003677]; mitochondrial transcription factor activity [GO:0034246]; RNA binding [GO:0003723]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]; rRNA methylation [GO:0031167]; rRNA modification [GO:0000154]; transcription initiation at mitochondrial promoter [GO:0006391]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11809803}.
Q8WVM7	reviewed	STAG1_HUMAN	Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1)	STAG1 SA1 SCC3	Homo sapiens (Human)	1258	FUNCTION: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.		cell division [GO:0051301]; establishment of mitotic sister chromatid cohesion [GO:0034087]; localization [GO:0051179]; mitotic spindle assembly [GO:0090307]; sister chromatid cohesion [GO:0007062]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; cell division [GO:0051301]; establishment of mitotic sister chromatid cohesion [GO:0034087]; localization [GO:0051179]; mitotic spindle assembly [GO:0090307]; sister chromatid cohesion [GO:0007062]	SUBCELLULAR LOCATION: Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Q8WVM8	reviewed	SCFD1_HUMAN	Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2)	SCFD1 C14orf163 KIAA0917 STXBP1L2 FKSG23	Homo sapiens (Human)	642	FUNCTION: Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}.		cell morphogenesis [GO:0000902]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of autophagosome assembly [GO:1902902]; post-Golgi vesicle-mediated transport [GO:0006892]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein transport [GO:0051223]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; plasma membrane [GO:0005886]	protein-containing complex binding [GO:0044877]; syntaxin binding [GO:0019905]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; plasma membrane [GO:0005886]; protein-containing complex binding [GO:0044877]; syntaxin binding [GO:0019905]; cell morphogenesis [GO:0000902]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of autophagosome assembly [GO:1902902]; post-Golgi vesicle-mediated transport [GO:0006892]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein transport [GO:0051223]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q8WVN6	reviewed	SCTM1_HUMAN	Secreted and transmembrane protein 1 (Protein K-12)	SECTM1 K12	Homo sapiens (Human)	248	FUNCTION: May be involved in thymocyte signaling. {ECO:0000269|PubMed:15742156}.		immune response [GO:0006955]; mesoderm development [GO:0007498]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; immune response [GO:0006955]; mesoderm development [GO:0007498]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted.
Q8WVN8	reviewed	UB2Q2_HUMAN	Ubiquitin-conjugating enzyme E2 Q2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q2) (Ubiquitin carrier protein Q2) (Ubiquitin-protein ligase Q2)	UBE2Q2	Homo sapiens (Human)	375	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. {ECO:0000269|PubMed:20061386}.		protein K48-linked ubiquitination [GO:0070936]	cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; protein K48-linked ubiquitination [GO:0070936]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16300736}.
Q8WVP5	reviewed	TP8L1_HUMAN	Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1) (TNF alpha-induced protein 8-like protein 1) (TNFAIP8-like protein 1) (Oxidative stress-regulated gene-beta) (Oxy-beta)	TNFAIP8L1	Homo sapiens (Human)	186	FUNCTION: Acts as a negative regulator of mTOR activity. {ECO:0000250|UniProtKB:Q8K288}.		negative regulation of TOR signaling [GO:0032007]; regulation of apoptotic process [GO:0042981]	cytoplasm [GO:0005737]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; negative regulation of TOR signaling [GO:0032007]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8K288}.
Q8WVP7	reviewed	LMBR1_HUMAN	Limb region 1 protein homolog (Differentiation-related gene 14 protein)	LMBR1 C7orf2 DIF14	Homo sapiens (Human)	490	FUNCTION: Putative membrane receptor.		embryonic digit morphogenesis [GO:0042733]; signal transduction [GO:0007165]	membrane [GO:0016020]	transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; transmembrane signaling receptor activity [GO:0004888]; embryonic digit morphogenesis [GO:0042733]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q8WVQ1	reviewed	CANT1_HUMAN	Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107)	CANT1 SHAPY	Homo sapiens (Human)	401	FUNCTION: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15248776, PubMed:15006348, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336). {ECO:0000269|PubMed:12234496, ECO:0000269|PubMed:15006348, ECO:0000269|PubMed:15248776, ECO:0000269|PubMed:16835225, ECO:0000269|PubMed:22539336}.	MISCELLANEOUS: Not inhibited by azide.	positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteoglycan biosynthetic process [GO:0030166]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	ADP phosphatase activity [GO:0043262]; calcium ion binding [GO:0005509]; GDP phosphatase activity [GO:0004382]; protein homodimerization activity [GO:0042803]; UDP phosphatase activity [GO:0045134]	endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; ADP phosphatase activity [GO:0043262]; calcium ion binding [GO:0005509]; GDP phosphatase activity [GO:0004382]; protein homodimerization activity [GO:0042803]; UDP phosphatase activity [GO:0045134]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteoglycan biosynthetic process [GO:0030166]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12234496}; Single-pass type II membrane protein {ECO:0000269|PubMed:12234496}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12234496}; Single-pass type II membrane protein {ECO:0000269|PubMed:12234496}. Cell membrane {ECO:0000269|PubMed:16835225}. Note=Processed form: Secreted.
Q8WVR3	reviewed	TPC14_HUMAN	Trafficking protein particle complex subunit 14 (Microtubule-associated protein 11)	TRAPPC14 C7orf43 MAP11	Homo sapiens (Human)	580	FUNCTION: Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (PubMed:31467083, PubMed:30715179). TRAPP II complex has also GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis (PubMed:31467083). Modulates YAP1 activity as transcriptional regulator (PubMed:30447097). {ECO:0000250|UniProtKB:Q3TLI0, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:30715179, ECO:0000269|PubMed:31467083}.		cilium assembly [GO:0060271]; regulation of cell population proliferation [GO:0042127]	centriolar satellite [GO:0034451]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; plasma membrane [GO:0005886]; TRAPPII protein complex [GO:1990071]	alpha-tubulin binding [GO:0043014]	centriolar satellite [GO:0034451]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; plasma membrane [GO:0005886]; TRAPPII protein complex [GO:1990071]; alpha-tubulin binding [GO:0043014]; cilium assembly [GO:0060271]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:30715179}. Vesicle {ECO:0000269|PubMed:30715179, ECO:0000269|PubMed:31467083}. Midbody {ECO:0000269|PubMed:30715179}. Cytoplasm {ECO:0000269|PubMed:31467083}. Note=During mitosis, precedes alpha-tubulin in gap formation of cell abscission at the midbody and is co-localized with PLK1 at the edges of microtubules extensions of daughter cells post cytokinesis abscission (PubMed:30715179). Colocalizes with RAB3IP on preciliary vesicles (PubMed:31467083). {ECO:0000269|PubMed:30715179, ECO:0000269|PubMed:31467083}.
Q8WVS4	reviewed	DC2I1_HUMAN	Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60)	DYNC2I1 WDR60	Homo sapiens (Human)	1066	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:23910462, PubMed:25205765, PubMed:31451806, PubMed:29742051). DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella (PubMed:29742051, PubMed:30320547, PubMed:30649997). Requires also to maintain a functional transition zone (PubMed:30320547). {ECO:0000269|PubMed:23910462, ECO:0000269|PubMed:25205765, ECO:0000269|PubMed:29742051, ECO:0000269|PubMed:30320547, ECO:0000269|PubMed:30649997, ECO:0000269|PubMed:31451806}.		cilium assembly [GO:0060271]; embryonic skeletal system morphogenesis [GO:0048704]; intraciliary retrograde transport [GO:0035721]	centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; extracellular space [GO:0005615]; pericentriolar material [GO:0000242]	dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]	centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; extracellular space [GO:0005615]; pericentriolar material [GO:0000242]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; cilium assembly [GO:0060271]; embryonic skeletal system morphogenesis [GO:0048704]; intraciliary retrograde transport [GO:0035721]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:23910462}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25205765}. Note=Located at the base of the primary cilium in serum-starved fibroblasts. {ECO:0000269|PubMed:23910462}.
Q8WVT3	reviewed	TPC12_HUMAN	Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis)	TRAPPC12 TRAMM TTC15 CGI-87	Homo sapiens (Human)	735	FUNCTION: Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}.		COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; metaphase chromosome alignment [GO:0051310]; positive regulation of protein localization to kinetochore [GO:1905342]; regulation of kinetochore assembly [GO:0090234]; vesicle tethering [GO:0099022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; metaphase chromosome alignment [GO:0051310]; positive regulation of protein localization to kinetochore [GO:1905342]; regulation of kinetochore assembly [GO:0090234]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:21525244}. Nucleus {ECO:0000269|PubMed:25918224}. Note=Mainly localizes to structures resembling the Golgi and a small amount is found in the nucleus. {ECO:0000269|PubMed:25918224}.
Q8WVV4	reviewed	POF1B_HUMAN	Protein POF1B (Premature ovarian failure protein 1B)	POF1B	Homo sapiens (Human)	589	FUNCTION: Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}.		actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; bicellular tight junction assembly [GO:0070830]; epithelial cell morphogenesis [GO:0003382]	actin filament [GO:0005884]; adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; desmosome [GO:0030057]	actin filament binding [GO:0051015]	actin filament [GO:0005884]; adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; desmosome [GO:0030057]; actin filament binding [GO:0051015]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; bicellular tight junction assembly [GO:0070830]; epithelial cell morphogenesis [GO:0003382]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:21940798}.
Q8WVV5	reviewed	BT2A2_HUMAN	Butyrophilin subfamily 2 member A2	BTN2A2 BT2.2 BTF2	Homo sapiens (Human)	523	FUNCTION: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. {ECO:0000250}.		ERK1 and ERK2 cascade [GO:0070371]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of T cell receptor signaling pathway [GO:0050860]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; signaling receptor binding [GO:0005102]; ERK1 and ERK2 cascade [GO:0070371]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of T cell receptor signaling pathway [GO:0050860]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8WVV9	reviewed	HNRLL_HUMAN	Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor)	HNRNPLL HNRPLL SRRF BLOCK24	Homo sapiens (Human)	542	FUNCTION: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}.		mRNA processing [GO:0006397]; positive regulation of RNA splicing [GO:0033120]; regulation of RNA splicing [GO:0043484]	membrane [GO:0016020]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	membrane [GO:0016020]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; positive regulation of RNA splicing [GO:0033120]; regulation of RNA splicing [GO:0043484]	
Q8WVX3	reviewed	CD003_HUMAN	Uncharacterized protein C4orf3 (Hepatitis C virus F protein-transactivated protein 1) (HCV F-transactivated protein 1)	C4orf3	Homo sapiens (Human)	66				endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8WVX9	reviewed	FACR1_HUMAN	Fatty acyl-CoA reductase 1 (EC 1.2.1.84) (Male sterility domain-containing protein 2)	FAR1 MLSTD2 UNQ2423/PRO4981	Homo sapiens (Human)	515	FUNCTION: Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (PubMed:20071337, PubMed:24108123, PubMed:33239752). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity). {ECO:0000250|UniProtKB:Q922J9, ECO:0000269|PubMed:15220348, ECO:0000269|PubMed:20071337, ECO:0000269|PubMed:24108123, ECO:0000269|PubMed:33239752}.		ether lipid biosynthetic process [GO:0008611]; glycerophospholipid biosynthetic process [GO:0046474]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025]	peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	alcohol-forming long-chain fatty acyl-CoA reductase activity [GO:0102965]; alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019]; oxidoreductase activity [GO:0016491]	peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; alcohol-forming long-chain fatty acyl-CoA reductase activity [GO:0102965]; alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019]; oxidoreductase activity [GO:0016491]; ether lipid biosynthetic process [GO:0008611]; glycerophospholipid biosynthetic process [GO:0046474]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:24108123}; Single-pass membrane protein {ECO:0000269|PubMed:24108123}.
Q8WVY7	reviewed	UBCP1_HUMAN	Ubiquitin-like domain-containing CTD phosphatase 1 (EC 3.1.3.16) (Nuclear proteasome inhibitor UBLCP1)	UBLCP1	Homo sapiens (Human)	318	FUNCTION: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity (PubMed:21949367, PubMed:28539385). Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1 (PubMed:28539385). Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly (PubMed:28539385). Has also been reported to stimulate the proteolytic activity of the 26S proteasome (PubMed:32071216). {ECO:0000269|PubMed:21949367, ECO:0000269|PubMed:28539385, ECO:0000269|PubMed:32071216}.		protein dephosphorylation [GO:0006470]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15883030, ECO:0000269|PubMed:21949367, ECO:0000269|PubMed:28539385}. Note=Colocalizes with nuclear proteasomes.
Q8WVZ1	reviewed	ZDH19_HUMAN	Palmitoyltransferase ZDHHC19 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 19) (DHHC-19)	ZDHHC19	Homo sapiens (Human)	309	FUNCTION: Palmitoyltransferase that mediates palmitoylation of RRAS, leading to increased cell viability. {ECO:0000269|PubMed:20074548}.; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. {ECO:0000269|PubMed:30404808}.		peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein targeting to membrane [GO:0006612]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; perinucleolar compartment [GO:0097356]	protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; perinucleolar compartment [GO:0097356]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:20074548, ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20074548}.
Q8WVZ9	reviewed	KBTB7_HUMAN	Kelch repeat and BTB domain-containing protein 7	KBTBD7	Homo sapiens (Human)	684	FUNCTION: As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205). {ECO:0000269|PubMed:25684205}.		negative regulation of signal transduction [GO:0009968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of Rac protein signal transduction [GO:0035020]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; nucleus [GO:0005634]		Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; nucleus [GO:0005634]; negative regulation of signal transduction [GO:0009968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of Rac protein signal transduction [GO:0035020]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:25684205}. Nucleus {ECO:0000305|PubMed:25684205}.
Q8WW01	reviewed	SEN15_HUMAN	tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15)	TSEN15 C1orf19 SEN15	Homo sapiens (Human)	171	FUNCTION: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini (PubMed:15109492, PubMed:27392077). There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492). {ECO:0000269|PubMed:15109492, ECO:0000269|PubMed:27392077}.		mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	nucleic acid binding [GO:0003676]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleic acid binding [GO:0003676]; mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Note=May be transiently localized in the nucleolus. {ECO:0000305}.
Q8WW12	reviewed	PCNP_HUMAN	PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein)	PCNP	Homo sapiens (Human)	178	FUNCTION: May be involved in cell cycle regulation.		cell cycle [GO:0007049]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell cycle [GO:0007049]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12176013}.
Q8WW22	reviewed	DNJA4_HUMAN	DnaJ homolog subfamily A member 4	DNAJA4	Homo sapiens (Human)	397			negative regulation of endothelial cell migration [GO:0010596]; negative regulation of inclusion body assembly [GO:0090084]; positive regulation of gene expression [GO:0010628]; protein refolding [GO:0042026]; response to heat [GO:0009408]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of inclusion body assembly [GO:0090084]; positive regulation of gene expression [GO:0010628]; protein refolding [GO:0042026]; response to heat [GO:0009408]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Q8WW24	reviewed	TEKT4_HUMAN	Tektin-4	TEKT4	Homo sapiens (Human)	435	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme (PubMed:36191189). Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Contributes to normal sperm motility (By similarity). {ECO:0000250|UniProtKB:Q2TA38, ECO:0000250|UniProtKB:Q6X6Z7, ECO:0000269|PubMed:36191189}.		cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; regulation of brood size [GO:0060378]	axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]		axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; regulation of brood size [GO:0060378]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q149S1}. Note=Found in the abaxial (convex) surface of outer dense fibers in sperm flagella. {ECO:0000250|UniProtKB:Q149S1}.
Q8WW34	reviewed	TM239_HUMAN	Transmembrane protein 239	TMEM239	Homo sapiens (Human)	195				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8WW35	reviewed	DYT2B_HUMAN	Dynein light chain Tctex-type protein 2B (Tctex1 domain-containing protein 2)	DYNLT2B TCTEX1D2	Homo sapiens (Human)	142	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. Required for proper retrograde ciliary transport. {ECO:0000269|PubMed:26044572, ECO:0000269|PubMed:29742051}.		cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; microtubule-based movement [GO:0007018]; regulation of cilium assembly [GO:1902017]; regulation of intraciliary retrograde transport [GO:1905799]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; dynein axonemal particle [GO:0120293]	dynein intermediate chain binding [GO:0045505]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; dynein axonemal particle [GO:0120293]; dynein intermediate chain binding [GO:0045505]; cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; microtubule-based movement [GO:0007018]; regulation of cilium assembly [GO:1902017]; regulation of intraciliary retrograde transport [GO:1905799]	SUBCELLULAR LOCATION: Dynein axonemal particle {ECO:0000305}.
Q8WW38	reviewed	FOG2_HUMAN	Zinc finger protein ZFPM2 (Friend of GATA protein 2) (FOG-2) (Friend of GATA 2) (hFOG-2) (Zinc finger protein 89B) (Zinc finger protein multitype 2)	ZFPM2 FOG2 ZNF89B	Homo sapiens (Human)	1151	FUNCTION: Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:10438528}.	MISCELLANEOUS: [Isoform 2]: Sequence incomplete. {ECO:0000305}.	cell differentiation [GO:0030154]; embryonic organ development [GO:0048568]; fat cell differentiation [GO:0045444]; gonadal mesoderm development [GO:0007506]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of female gonad development [GO:2000195]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; right ventricular cardiac muscle tissue morphogenesis [GO:0003221]; vasculogenesis [GO:0001570]; ventricular septum morphogenesis [GO:0060412]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; embryonic organ development [GO:0048568]; fat cell differentiation [GO:0045444]; gonadal mesoderm development [GO:0007506]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of female gonad development [GO:2000195]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; right ventricular cardiac muscle tissue morphogenesis [GO:0003221]; vasculogenesis [GO:0001570]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23226341}.
Q8WW43	reviewed	APH1B_HUMAN	Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin-stabilization factor-like)	APH1B PSFL UNQ688/PRO1328	Homo sapiens (Human)	257	FUNCTION: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. {ECO:0000269|PubMed:12297508}.	MISCELLANEOUS: [Isoform 2]: Expressed at low levels in most tissues. {ECO:0000305}.	amyloid precursor protein catabolic process [GO:0042987]; amyloid-beta formation [GO:0034205]; membrane protein intracellular domain proteolysis [GO:0031293]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; gamma-secretase complex [GO:0070765]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]	endopeptidase activator activity [GO:0061133]; protein-macromolecule adaptor activity [GO:0030674]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; gamma-secretase complex [GO:0070765]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; endopeptidase activator activity [GO:0061133]; protein-macromolecule adaptor activity [GO:0030674]; amyloid precursor protein catabolic process [GO:0042987]; amyloid-beta formation [GO:0034205]; membrane protein intracellular domain proteolysis [GO:0031293]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8WWA0	reviewed	ITLN1_HUMAN	Intelectin-1 (ITLN-1) (Endothelial lectin HL-1) (Galactofuranose-binding lectin) (Intestinal lactoferrin receptor) (Omentin)	ITLN1 INTL ITLN LFR UNQ640/PRO1270	Homo sapiens (Human)	313	FUNCTION: Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499). {ECO:0000269|PubMed:11313366, ECO:0000269|PubMed:16531507, ECO:0000269|PubMed:23921499, ECO:0000269|PubMed:26148048, ECO:0000305, ECO:0000305|PubMed:11747454}.		positive regulation of glucose import [GO:0046326]; positive regulation of protein phosphorylation [GO:0001934]; protein homotrimerization [GO:0070207]; response to nematode [GO:0009624]	brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; receptor complex [GO:0043235]; side of membrane [GO:0098552]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; oligosaccharide binding [GO:0070492]	brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; receptor complex [GO:0043235]; side of membrane [GO:0098552]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; oligosaccharide binding [GO:0070492]; positive regulation of glucose import [GO:0046326]; positive regulation of protein phosphorylation [GO:0001934]; protein homotrimerization [GO:0070207]; response to nematode [GO:0009624]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:11747454}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:11747454}. Secreted {ECO:0000269|PubMed:11313366, ECO:0000269|PubMed:16531507, ECO:0000305|PubMed:11747454}. Note=Enriched in lipid rafts. {ECO:0000250|UniProtKB:O88310}.
Q8WWB3	reviewed	DYDC1_HUMAN	DPY30 domain-containing protein 1	DYDC1 DPY30D1 RSD-9 RSD9	Homo sapiens (Human)	177	FUNCTION: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (By similarity). Plays a crucial role during acrosome biogenesis (PubMed:19545932). {ECO:0000250|UniProtKB:Q9D9T0, ECO:0000269|PubMed:19545932}.			cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; Set1C/COMPASS complex [GO:0048188]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; Set1C/COMPASS complex [GO:0048188]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9D9T0}.
Q8WWB5	reviewed	PIHD2_HUMAN	PIH1 domain-containing protein 2	PIH1D2	Homo sapiens (Human)	315		MISCELLANEOUS: [Isoform 3]: May be due to a competing donor splice site. {ECO:0000305}.	box C/D snoRNP assembly [GO:0000492]; protein stabilization [GO:0050821]; rRNA processing [GO:0006364]	cytoplasm [GO:0005737]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]	small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; small GTPase binding [GO:0031267]; box C/D snoRNP assembly [GO:0000492]; protein stabilization [GO:0050821]; rRNA processing [GO:0006364]	
Q8WWB7	reviewed	GLMP_HUMAN	Glycosylated lysosomal membrane protein (Lysosomal protein NCU-G1)	GLMP C1orf85 PSEC0030 UNQ2553/PRO6182	Homo sapiens (Human)	406	FUNCTION: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. {ECO:0000250|UniProtKB:Q9JHJ3}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821]	cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]		cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:19556463}; Single-pass type I membrane protein {ECO:0000255}; Lumenal side {ECO:0000305}.
Q8WWC4	reviewed	MAIP1_HUMAN	m-AAA protease-interacting protein 1, mitochondrial (Matrix AAA peptidase-interacting protein 1)	MAIP1 C2orf47	Homo sapiens (Human)	291	FUNCTION: Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation (PubMed:27642048). Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) (PubMed:27642048). {ECO:0000269|PubMed:27642048}.		calcium import into the mitochondrion [GO:0036444]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion homeostasis [GO:0051560]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein insertion into mitochondrial membrane [GO:0051204]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]	ribosome binding [GO:0043022]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; ribosome binding [GO:0043022]; calcium import into the mitochondrion [GO:0036444]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion homeostasis [GO:0051560]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein insertion into mitochondrial membrane [GO:0051204]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:27642048}.
Q8WWF3	reviewed	SSMM1_HUMAN	Serine-rich single-pass membrane protein 1	SSMEM1 C7orf45	Homo sapiens (Human)	244				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8WWF5	reviewed	ZNRF4_HUMAN	E3 ubiquitin-protein ligase ZNRF4 (EC 2.3.2.27) (Nixin) (RING finger protein 204) (RING-type E3 ubiquitin transferase ZNRF4) (Zinc/RING finger protein 4)	ZNRF4 RNF204	Homo sapiens (Human)	429	FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 (PubMed:28656966). Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830). Could have a role in spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q9DAH2, ECO:0000269|PubMed:21205830, ECO:0000269|PubMed:28656966}.		negative regulation of cell cycle [GO:0045786]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of cell cycle [GO:0045786]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21205830, ECO:0000269|PubMed:24387786, ECO:0000269|PubMed:28656966}; Single-pass type I membrane protein {ECO:0000255}.
Q8WWG9	reviewed	KCNE4_HUMAN	Potassium voltage-gated channel subfamily E member 4 (MinK-related peptide 3) (Minimum potassium ion channel-related peptide 3) (Potassium channel subunit beta MiRP3)	KCNE4	Homo sapiens (Human)	221	FUNCTION: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.		membrane repolarization during action potential [GO:0086011]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; potassium ion export across plasma membrane [GO:0097623]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005]	apical plasma membrane [GO:0016324]	potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	apical plasma membrane [GO:0016324]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; potassium ion export across plasma membrane [GO:0097623]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8WWH4	reviewed	ASZ1_HUMAN	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Ankyrin-like protein 1) (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)	ASZ1 ALP1 ANKL1 C7orf7 GASZ	Homo sapiens (Human)	475	FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; pi-body [GO:0071546]		cytoplasm [GO:0005737]; pi-body [GO:0071546]; cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs (By similarity). {ECO:0000250}.
Q8WWH5	reviewed	TRUB1_HUMAN	Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25)	TRUB1 PUS4	Homo sapiens (Human)	349	FUNCTION: Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:32926445, ECO:0000269|PubMed:33023933}.		mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of pre-miRNA processing [GO:2000633]; tRNA modification [GO:0006400]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	pre-miRNA binding [GO:0070883]; pseudouridine synthase activity [GO:0009982]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pre-miRNA binding [GO:0070883]; pseudouridine synthase activity [GO:0009982]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of pre-miRNA processing [GO:2000633]; tRNA modification [GO:0006400]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:33023933}. Cytoplasm, cytosol {ECO:0000269|PubMed:28073919}. Note=Catalyzes pseudouridylation of mRNAs in the nucleus. {ECO:0000269|PubMed:28073919}.
Q8WWI1	reviewed	LMO7_HUMAN	LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)	LMO7 FBX20 FBXO20 KIAA0858	Homo sapiens (Human)	1683			positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of cell adhesion [GO:0030155]; regulation of signaling [GO:0023051]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of cell adhesion [GO:0030155]; regulation of signaling [GO:0023051]	
Q8WWI5	reviewed	CTL1_HUMAN	Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92)	SLC44A1 CD92 CDW92 CTL1	Homo sapiens (Human)	657	FUNCTION: Choline/H+ antiporter (PubMed:19357133, PubMed:31855247, PubMed:33789160, PubMed:23651124). Also acts as a high-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway (PubMed:33789160). Involved in membrane synthesis and myelin production (PubMed:31855247). {ECO:0000269|PubMed:19357133, ECO:0000269|PubMed:23651124, ECO:0000269|PubMed:31855247, ECO:0000269|PubMed:33789160}.		choline catabolic process [GO:0042426]; choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]; choline catabolic process [GO:0042426]; choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19357133, ECO:0000269|PubMed:31855247}; Multi-pass membrane protein {ECO:0000269|PubMed:19357133}. Mitochondrion outer membrane {ECO:0000269|PubMed:19357133}; Multi-pass membrane protein {ECO:0000269|PubMed:19357133}.
Q8WWK9	reviewed	CKAP2_HUMAN	Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein)	CKAP2 LB1 TMAP	Homo sapiens (Human)	683	FUNCTION: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}.		apoptotic process [GO:0006915]; mitotic cytokinesis [GO:0000281]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of transcription by RNA polymerase II [GO:0045944]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]; apoptotic process [GO:0006915]; mitotic cytokinesis [GO:0000281]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.
Q8WWL2	reviewed	SPIR2_HUMAN	Protein spire homolog 2 (Spir-2)	SPIRE2 KIAA1832 SPIR2	Homo sapiens (Human)	714	FUNCTION: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). {ECO:0000250|UniProtKB:Q8K1S6, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480}.		actin cytoskeleton organization [GO:0030036]; actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; Golgi vesicle transport [GO:0048193]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]	actin binding [GO:0003779]	cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; actin binding [GO:0003779]; actin cytoskeleton organization [GO:0030036]; actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; Golgi vesicle transport [GO:0048193]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8K1S6}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8K1S6}. Cell membrane {ECO:0000250|UniProtKB:Q8K1S6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8K1S6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8K1S6}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8K1S6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8K1S6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8K1S6}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250|UniProtKB:Q8K1S6}.
Q8WWL7	reviewed	CCNB3_HUMAN	G2/mitotic-specific cyclin-B3	CCNB3 CYCB3	Homo sapiens (Human)	1395	FUNCTION: Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. {ECO:0000269|PubMed:12185076}.		cell division [GO:0051301]; meiotic cell cycle [GO:0051321]; mitotic cell cycle phase transition [GO:0044772]	centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; cell division [GO:0051301]; meiotic cell cycle [GO:0051321]; mitotic cell cycle phase transition [GO:0044772]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12185076}.
Q8WWM7	reviewed	ATX2L_HUMAN	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein)	ATXN2L A2D A2LG A2LP A2RP	Homo sapiens (Human)	1075	FUNCTION: Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.	MISCELLANEOUS: [Isoform 6]: Due to intron retention. {ECO:0000305}.	mRNA metabolic process [GO:0016071]; stress granule assembly [GO:0034063]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]	cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA metabolic process [GO:0016071]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11784712}; Peripheral membrane protein {ECO:0000269|PubMed:11784712}. Cytoplasm {ECO:0000269|PubMed:23209657}. Nucleus speckle {ECO:0000269|PubMed:23209657}. Cytoplasmic granule {ECO:0000269|PubMed:23209657}. Note=Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791). Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791). {ECO:0000269|PubMed:23209657, ECO:0000269|PubMed:25748791}.
Q8WWM9	reviewed	CYGB_HUMAN	Cytoglobin (Histoglobin) (HGb) (Stellate cell activation-associated protein)	CYGB STAP	Homo sapiens (Human)	190	FUNCTION: May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.		fatty acid oxidation [GO:0019395]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of hepatic stellate cell activation [GO:2000490]; oxygen transport [GO:0015671]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]	cytosol [GO:0005829]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]	catalase activity [GO:0004096]; fatty acid peroxidase activity [GO:0047888]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; peroxidase activity [GO:0004601]	cytosol [GO:0005829]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; catalase activity [GO:0004096]; fatty acid peroxidase activity [GO:0047888]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; peroxidase activity [GO:0004601]; fatty acid oxidation [GO:0019395]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of hepatic stellate cell activation [GO:2000490]; oxygen transport [GO:0015671]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8WWN8	reviewed	ARAP3_HUMAN	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3)	ARAP3 CENTD3	Homo sapiens (Human)	1544	FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}.		cytoskeleton organization [GO:0007010]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; cytoskeleton organization [GO:0007010]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia. {ECO:0000250}.
Q8WWN9	reviewed	ICEF1_HUMAN	Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E)	IPCEF1 KIAA0403	Homo sapiens (Human)	437	FUNCTION: Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. {ECO:0000250}.		oxygen transport [GO:0015671]; response to oxidative stress [GO:0006979]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	oxygen carrier activity [GO:0005344]; peroxidase activity [GO:0004601]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; oxygen carrier activity [GO:0005344]; peroxidase activity [GO:0004601]; oxygen transport [GO:0015671]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated with PSCD2 to the plasma membrane upon epidermal growth factor (EGF) stimulation. {ECO:0000250}.
Q8WWP7	reviewed	GIMA1_HUMAN	GTPase IMAP family member 1 (Immunity-associated protein 1) (hIMAP1)	GIMAP1 IMAP1	Homo sapiens (Human)	306	FUNCTION: May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). {ECO:0000250}.			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	GTP binding [GO:0005525]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; GTP binding [GO:0005525]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P70224}; Single-pass type IV membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P70224}; Single-pass type IV membrane protein {ECO:0000305}.
Q8WWQ0	reviewed	PHIP_HUMAN	PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11)	PHIP DCAF14 WDR11	Homo sapiens (Human)	1821	FUNCTION: Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}.		cytoskeleton organization [GO:0007010]; insulin receptor signaling pathway [GO:0008286]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	insulin receptor binding [GO:0005158]; lysine-acetylated histone binding [GO:0070577]	nucleus [GO:0005634]; insulin receptor binding [GO:0005158]; lysine-acetylated histone binding [GO:0070577]; cytoskeleton organization [GO:0007010]; insulin receptor signaling pathway [GO:0008286]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309}.
Q8WWQ2	reviewed	HPSE2_HUMAN	Inactive heparanase-2 (Hpa2)	HPSE2 HPA2	Homo sapiens (Human)	592	FUNCTION: Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). {ECO:0000269|PubMed:20576607}.		cell population proliferation [GO:0008283]; extracellular matrix organization [GO:0030198]; positive regulation of cell population proliferation [GO:0008284]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	heparan sulfate proteoglycan binding [GO:0043395]; heparanase activity [GO:0030305]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; heparan sulfate proteoglycan binding [GO:0043395]; heparanase activity [GO:0030305]; cell population proliferation [GO:0008283]; extracellular matrix organization [GO:0030198]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20576607}.
Q8WWQ8	reviewed	STAB2_HUMAN	Stabilin-2 (FAS1 EGF-like and X-link domain-containing adhesion molecule 2) (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) (Hyaluronan receptor for endocytosis) [Cleaved into: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)]	STAB2 FEEL2 FELL FEX2 HARE	Homo sapiens (Human)	2551	FUNCTION: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS. {ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:12473645, ECO:0000269|PubMed:15208308, ECO:0000269|PubMed:15572036, ECO:0000269|PubMed:17145755, ECO:0000269|PubMed:17675564, ECO:0000269|PubMed:17962816, ECO:0000269|PubMed:18230608, ECO:0000269|PubMed:18434317, ECO:0000269|PubMed:18573870, ECO:0000269|PubMed:19359419}.		angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; endocytosis [GO:0006897]; hyaluronan catabolic process [GO:0030214]; receptor-mediated endocytosis [GO:0006898]	cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-disulfide reductase activity [GO:0015035]; scavenger receptor activity [GO:0005044]	cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-disulfide reductase activity [GO:0015035]; scavenger receptor activity [GO:0005044]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; endocytosis [GO:0006897]; hyaluronan catabolic process [GO:0030214]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17675564}; Single-pass type I membrane protein {ECO:0000269|PubMed:17675564}. Cytoplasm {ECO:0000269|PubMed:17145755}. Note=Only a small amount appears to be present at the cell surface (PubMed:17145755).
Q8WWR8	reviewed	NEUR4_HUMAN	Sialidase-4 (EC 3.2.1.18) (N-acetyl-alpha-neuraminidase 4)	NEU4 LP5125	Homo sapiens (Human)	484	FUNCTION: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:15847605, PubMed:21521691, PubMed:15213228). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605). {ECO:0000250|UniProtKB:Q8BZL1, ECO:0000269|PubMed:15213228, ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:21521691}.		ganglioside catabolic process [GO:0006689]; glycoprotein catabolic process [GO:0006516]; negative regulation of neuron projection development [GO:0010977]; oligosaccharide catabolic process [GO:0009313]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; neuron projection [GO:0043005]; organelle inner membrane [GO:0019866]; plasma membrane [GO:0005886]	exo-alpha-(2->3)-sialidase activity [GO:0052794]; exo-alpha-(2->6)-sialidase activity [GO:0052795]; exo-alpha-(2->8)-sialidase activity [GO:0052796]; exo-alpha-sialidase activity [GO:0004308]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; neuron projection [GO:0043005]; organelle inner membrane [GO:0019866]; plasma membrane [GO:0005886]; exo-alpha-(2->3)-sialidase activity [GO:0052794]; exo-alpha-(2->6)-sialidase activity [GO:0052795]; exo-alpha-(2->8)-sialidase activity [GO:0052796]; exo-alpha-sialidase activity [GO:0004308]; ganglioside catabolic process [GO:0006689]; glycoprotein catabolic process [GO:0006516]; negative regulation of neuron projection development [GO:0010977]; oligosaccharide catabolic process [GO:0009313]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:21521691}; Peripheral membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15847605}; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:15847605}; Peripheral membrane protein. Mitochondrion membrane {ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:19797320}; Peripheral membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q8BZL1}. Note=Predominantly associates with endoplasmic reticulum membranes. Only a small fraction associates with mitochondrial and plasma membranes. {ECO:0000269|PubMed:19797320, ECO:0000269|PubMed:21521691}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion inner membrane {ECO:0000269|PubMed:15847605}; Peripheral membrane protein. Mitochondrion outer membrane {ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:19797320}; Peripheral membrane protein. Lysosome lumen {ECO:0000269|PubMed:15213228}. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted from the sequence.
Q8WWT9	reviewed	S13A3_HUMAN	Na(+)/dicarboxylate cotransporter 3 (NaDC-3) (hNaDC3) (Na(+)-coupled carboxylate transporter 3) (NaC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) (Solute carrier family 13 member 3) (SLC13A3)	SLC13A3 NADC3 SDCT2	Homo sapiens (Human)	602	FUNCTION: High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate (PubMed:10794676, PubMed:10992006, PubMed:15561973, PubMed:17426067, PubMed:17356845, PubMed:24247155, PubMed:30635937). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:10794676, PubMed:10992006). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (PubMed:10794676). {ECO:0000269|PubMed:10794676, ECO:0000269|PubMed:10992006, ECO:0000269|PubMed:15561973, ECO:0000269|PubMed:17356845, ECO:0000269|PubMed:17426067, ECO:0000269|PubMed:24247155, ECO:0000269|PubMed:30635937}.		citrate transport [GO:0015746]; dicarboxylic acid transport [GO:0006835]; glutathione transmembrane transport [GO:0034775]; lipid transport [GO:0006869]; succinate transmembrane transport [GO:0071422]; transport across blood-brain barrier [GO:0150104]	basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; citrate transmembrane transporter activity [GO:0015137]; dicarboxylic acid transmembrane transporter activity [GO:0005310]; glutathione transmembrane transporter activity [GO:0034634]; high-affinity sodium:dicarboxylate symporter activity [GO:0015362]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]	basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; citrate transmembrane transporter activity [GO:0015137]; dicarboxylic acid transmembrane transporter activity [GO:0005310]; glutathione transmembrane transporter activity [GO:0034634]; high-affinity sodium:dicarboxylate symporter activity [GO:0015362]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]; citrate transport [GO:0015746]; dicarboxylic acid transport [GO:0006835]; glutathione transmembrane transport [GO:0034775]; lipid transport [GO:0006869]; succinate transmembrane transport [GO:0071422]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16331647, ECO:0000269|PubMed:17426067}; Multi-pass membrane protein {ECO:0000269|PubMed:16331647, ECO:0000269|PubMed:17426067}.
Q8WWU5	reviewed	TCP11_HUMAN	T-complex protein 11 homolog	TCP11	Homo sapiens (Human)	503	FUNCTION: Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway. {ECO:0000250|UniProtKB:Q01755}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; germ cell development [GO:0007281]; protein kinase A signaling [GO:0010737]; regulation of sperm capacitation [GO:1902490]; spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]		acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; germ cell development [GO:0007281]; protein kinase A signaling [GO:0010737]; regulation of sperm capacitation [GO:1902490]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q01755}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q01755}. Note=Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm. {ECO:0000250|UniProtKB:Q01755}.
Q8WWV3	reviewed	RT4I1_HUMAN	Reticulon-4-interacting protein 1, mitochondrial (NOGO-interacting mitochondrial protein)	RTN4IP1 NIMP	Homo sapiens (Human)	396	FUNCTION: Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury. {ECO:0000250|UniProtKB:Q924D0}.		nervous system development [GO:0007399]; regulation of dendrite development [GO:0050773]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270]; nervous system development [GO:0007399]; regulation of dendrite development [GO:0050773]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:12067236, ECO:0000269|PubMed:26593267}. Note=Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria. {ECO:0000269|PubMed:26593267}.
Q8WWV6	reviewed	FCAMR_HUMAN	High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (Fc alpha/mu receptor) (CD antigen CD351)	FCAMR FKSG87	Homo sapiens (Human)	532	FUNCTION: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM. {ECO:0000269|PubMed:11779189}.		adaptive immune response [GO:0002250]	plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q8WWW0	reviewed	RASF5_HUMAN	Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL)	RASSF5 NORE1 RAPL	Homo sapiens (Human)	418	FUNCTION: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. {ECO:0000269|PubMed:12676952, ECO:0000269|PubMed:12845325, ECO:0000269|PubMed:15569673}.		apoptotic process [GO:0006915]; lymphocyte proliferation [GO:0046651]; negative regulation of lymphocyte proliferation [GO:0050672]; positive regulation of protein ubiquitination [GO:0031398]; regulation of protein localization to nucleus [GO:1900180]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; apoptotic process [GO:0006915]; lymphocyte proliferation [GO:0046651]; negative regulation of lymphocyte proliferation [GO:0050672]; positive regulation of protein ubiquitination [GO:0031398]; regulation of protein localization to nucleus [GO:1900180]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
Q8WWX8	reviewed	SC5AB_HUMAN	Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11)	SLC5A11 KST1 SLGTX SMIT2	Homo sapiens (Human)	675	FUNCTION: Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1 (PubMed:15172003, PubMed:19032932). Exclusively responsible for apical MI transport and absorption in intestine (By similarity). Can also transport D-chiro-inositol (DCI) but not L-fucose (PubMed:15172003, PubMed:19032932). Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity). May induce apoptosis through the TNF-alpha, PDCD1 pathway (PubMed:15172003, PubMed:18069935). May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity). {ECO:0000250|UniProtKB:Q28728, ECO:0000250|UniProtKB:Q9Z1F2, ECO:0000269|PubMed:15172003, ECO:0000269|PubMed:18069935, ECO:0000269|PubMed:19032932}.	MISCELLANEOUS: Acts as an autoimmune modifier in systemic lupus erythematosus (SLE) as it is significantly associated with low complement component 4 (C4), anti-Smith antibody, serositis, and alopecia. {ECO:0000269|PubMed:18069935}.	apoptotic process [GO:0006915]; myo-inositol transport [GO:0015798]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	glucose:sodium symporter activity [GO:0005412]; myo-inositol transmembrane transporter activity [GO:0005365]; polyol transmembrane transporter activity [GO:0015166]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; glucose:sodium symporter activity [GO:0005412]; myo-inositol transmembrane transporter activity [GO:0005365]; polyol transmembrane transporter activity [GO:0015166]; apoptotic process [GO:0006915]; myo-inositol transport [GO:0015798]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:19032932}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9Z1F2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Z1F2}. Note=Located on apical membrane of enterocytes (By similarity). Located on membrane of kidney brush border membrane vesicles (BBMVs) and apical membrane of proximal convoluted tubules (By similarity). {ECO:0000250|UniProtKB:Q28728, ECO:0000250|UniProtKB:Q9Z1F2}.
Q8WWX9	reviewed	SELM_HUMAN	Selenoprotein M (SelM)	SELENOM SELM	Homo sapiens (Human)	145	FUNCTION: May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation. {ECO:0000250}.		adipose tissue development [GO:0060612]; corticosterone secretion [GO:0035934]; hormone metabolic process [GO:0042445]; multicellular organism growth [GO:0035264]; response to selenium ion [GO:0010269]	endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]	oxidoreductase activity [GO:0016491]	endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; oxidoreductase activity [GO:0016491]; adipose tissue development [GO:0060612]; corticosterone secretion [GO:0035934]; hormone metabolic process [GO:0042445]; multicellular organism growth [GO:0035264]; response to selenium ion [GO:0010269]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11839807}. Endoplasmic reticulum {ECO:0000305|PubMed:11839807}. Golgi apparatus {ECO:0000305|PubMed:11839807}. Note=Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum.
Q8WWY3	reviewed	PRP31_HUMAN	U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31)	PRPF31 PRP31	Homo sapiens (Human)	499	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). {ECO:0000269|PubMed:11867543, ECO:0000269|PubMed:28781166}.		mRNA splicing, via spliceosome [GO:0000398]; ribonucleoprotein complex localization [GO:0071166]; spliceosomal tri-snRNP complex assembly [GO:0000244]	Cajal body [GO:0015030]; MLL1 complex [GO:0071339]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690]	identical protein binding [GO:0042802]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; snRNP binding [GO:0070990]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622]	Cajal body [GO:0015030]; MLL1 complex [GO:0071339]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690]; identical protein binding [GO:0042802]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; snRNP binding [GO:0070990]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622]; mRNA splicing, via spliceosome [GO:0000398]; ribonucleoprotein complex localization [GO:0071166]; spliceosomal tri-snRNP complex assembly [GO:0000244]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12444105, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:34023904}. Nucleus speckle {ECO:0000269|PubMed:11867543}. Nucleus, Cajal body {ECO:0000269|PubMed:11867543}. Note=Predominantly found in speckles and in Cajal bodies. {ECO:0000269|PubMed:11867543}.
Q8WWY6	reviewed	MB3L1_HUMAN	Methyl-CpG-binding domain protein 3-like 1 (MBD3-like protein 1)	MBD3L1 MBD3L	Homo sapiens (Human)	194	FUNCTION: Transcriptional repressor. {ECO:0000269|PubMed:12504854}.	MISCELLANEOUS: Does not bind methylated DNA.; MISCELLANEOUS: The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.	DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	methyl-CpG binding [GO:0008327]	nucleus [GO:0005634]; methyl-CpG binding [GO:0008327]; DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12504854}. Note=Nuclear, in large foci.
Q8WWY8	reviewed	LIPH_HUMAN	Lipase member H (LIPH) (EC 3.1.1.-) (LPD lipase-related protein) (Membrane-associated phosphatidic acid-selective phospholipase A1-alpha) (mPA-PLA1 alpha) (Phospholipase A1 member B)	LIPH LPDLR MPAPLA1 PLA1B	Homo sapiens (Human)	451	FUNCTION: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). {ECO:0000269|PubMed:12063250, ECO:0000269|PubMed:12963729}.		lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	carboxylic ester hydrolase activity [GO:0052689]; heparin binding [GO:0008201]; phospholipase activity [GO:0004620]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; carboxylic ester hydrolase activity [GO:0052689]; heparin binding [GO:0008201]; phospholipase activity [GO:0004620]; lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12963729}. Cell membrane {ECO:0000269|PubMed:12063250, ECO:0000269|PubMed:12963729}; Peripheral membrane protein.
Q8WWZ1	reviewed	IL1FA_HUMAN	Interleukin-1 family member 10 (IL-1F10) (Family of interleukin 1-theta) (FIL1 theta) (Interleukin-1 HY2) (IL-1HY2) (Interleukin-1 theta) (IL-1 theta) (Interleukin-38) (IL-38)	IL1F10 FIL1T IL1HY2 IL38 FKSG75 UNQ6119/PRO20041	Homo sapiens (Human)	152	FUNCTION: Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2. {ECO:0000269|PubMed:22315422}.		cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; inflammatory response to antigenic stimulus [GO:0002437]; positive regulation of gene expression [GO:0010628]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; inflammatory response to antigenic stimulus [GO:0002437]; positive regulation of gene expression [GO:0010628]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:32272059}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}.
Q8WWZ3	reviewed	EDAD_HUMAN	Ectodysplasin-A receptor-associated adapter protein (EDAR-associated death domain protein) (Protein crinkled homolog)	EDARADD	Homo sapiens (Human)	215	FUNCTION: Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B. {ECO:0000269|PubMed:11882293}.		cell differentiation [GO:0030154]; signal transduction [GO:0007165]	cytosol [GO:0005829]		cytosol [GO:0005829]; cell differentiation [GO:0030154]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8WWZ4	reviewed	ABCAA_HUMAN	ATP-binding cassette sub-family A member 10 (EC 7.6.2.-)	ABCA10	Homo sapiens (Human)	1543	FUNCTION: Probable transporter which may play a role in macrophage lipid transport and homeostasis. {ECO:0000305|PubMed:12821155}.		lipid transport [GO:0006869]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8WWZ7	reviewed	ABCA5_HUMAN	Cholesterol transporter ABCA5 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 5)	ABCA5 KIAA1888	Homo sapiens (Human)	1642	FUNCTION: Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity). {ECO:0000250|UniProtKB:Q8K448, ECO:0000269|PubMed:25125465}.		cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; high-density lipoprotein particle remodeling [GO:0034375]; lipid transport [GO:0006869]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; positive regulation of reverse cholesterol transport [GO:1903064]; regulation of cholesterol efflux [GO:0010874]; reverse cholesterol transport [GO:0043691]	Golgi membrane [GO:0000139]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]	Golgi membrane [GO:0000139]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; high-density lipoprotein particle remodeling [GO:0034375]; lipid transport [GO:0006869]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; positive regulation of reverse cholesterol transport [GO:1903064]; regulation of cholesterol efflux [GO:0010874]; reverse cholesterol transport [GO:0043691]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8CF82}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CF82}. Lysosome membrane {ECO:0000250|UniProtKB:Q8K448}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K448}. Late endosome membrane {ECO:0000250|UniProtKB:Q8K448}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K448}. Cell membrane {ECO:0000250|UniProtKB:Q8K448}. Note=Localized at cell membrane under high cholesterol levels. {ECO:0000250|UniProtKB:Q8K448}.
Q8WWZ8	reviewed	OIT3_HUMAN	Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein)	OIT3 LZP UNQ826/PRO1753	Homo sapiens (Human)	545	FUNCTION: May be involved in hepatocellular function and development. {ECO:0000269|PubMed:12939600}.		renal system process [GO:0003014]	nuclear envelope [GO:0005635]	calcium ion binding [GO:0005509]	nuclear envelope [GO:0005635]; calcium ion binding [GO:0005509]; renal system process [GO:0003014]	SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:12939600}. Note=Can be secreted into blood.
Q8WX92	reviewed	NELFB_HUMAN	Negative elongation factor B (NELF-B) (Cofactor of BRCA1)	NELFB COBRA1 KIAA1182	Homo sapiens (Human)	580	FUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity). {ECO:0000250|UniProtKB:Q8C4Y3, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11739404, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II (PubMed:23884411). In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1 (PubMed:23884411). {ECO:0000269|PubMed:23884411}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at a CTG start codon. {ECO:0000305|PubMed:26010750}.	cell population proliferation [GO:0008283]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; stem cell differentiation [GO:0048863]	cytoplasm [GO:0005737]; NELF complex [GO:0032021]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; NELF complex [GO:0032021]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; cell population proliferation [GO:0008283]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11739404}.
Q8WX93	reviewed	PALLD_HUMAN	Palladin (SIH002) (Sarcoma antigen NY-SAR-77)	PALLD KIAA0992 CGI-151	Homo sapiens (Human)	1383	FUNCTION: Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.		actin cytoskeleton organization [GO:0030036]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; dendrite self-avoidance [GO:0070593]; epithelial cell morphogenesis [GO:0003382]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte development [GO:0003334]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; axon [GO:0030424]; cytosol [GO:0005829]; excitatory synapse [GO:0060076]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; cell-cell adhesion mediator activity [GO:0098632]; muscle alpha-actinin binding [GO:0051371]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; axon [GO:0030424]; cytosol [GO:0005829]; excitatory synapse [GO:0060076]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; cell-cell adhesion mediator activity [GO:0098632]; muscle alpha-actinin binding [GO:0051371]; actin cytoskeleton organization [GO:0030036]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; dendrite self-avoidance [GO:0070593]; epithelial cell morphogenesis [GO:0003382]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte development [GO:0003334]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:17322171, ECO:0000269|PubMed:17537434}. Cell junction, focal adhesion {ECO:0000269|PubMed:17322171}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:16125169}. Cell projection, ruffle {ECO:0000269|PubMed:17537434}. Cell projection, podosome {ECO:0000250|UniProtKB:P0C5E3}. Cell projection, lamellipodium {ECO:0000269|PubMed:17537434}. Cell projection, axon {ECO:0000250|UniProtKB:P0C5E3}. Cell projection, growth cone {ECO:0000250|UniProtKB:P0C5E3}. Note=Localizes to stress fibers and Z lines (PubMed:11598191, PubMed:16125169, PubMed:17322171, PubMed:17537434). Preferentially expressed in the excitatory presynaptic terminals (By similarity). {ECO:0000250|UniProtKB:P0C5E3, ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:17322171, ECO:0000269|PubMed:17537434}.
Q8WX94	reviewed	NALP7_HUMAN	NACHT, LRR and PYD domains-containing protein 7 (Nucleotide-binding oligomerization domain protein 12) (PYRIN-containing APAF1-like protein 3)	NLRP7 NALP7 NOD12 PYPAF3	Homo sapiens (Human)	980	FUNCTION: Inhibits CASP1/caspase-1-dependent IL1B secretion. {ECO:0000269|PubMed:15817483}.		cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of protein processing [GO:0010955]; regulation of inflammatory response [GO:0050727]	cytoplasm [GO:0005737]	aspartic-type endopeptidase inhibitor activity [GO:0019828]; ATP binding [GO:0005524]; caspase binding [GO:0089720]; identical protein binding [GO:0042802]; interleukin-1 binding [GO:0019966]	cytoplasm [GO:0005737]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; ATP binding [GO:0005524]; caspase binding [GO:0089720]; identical protein binding [GO:0042802]; interleukin-1 binding [GO:0019966]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of protein processing [GO:0010955]; regulation of inflammatory response [GO:0050727]	
Q8WXA3	reviewed	RUFY2_HUMAN	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related)	RUFY2 KIAA1537 RABIP4R	Homo sapiens (Human)	606			regulation of endocytosis [GO:0030100]	cytoplasm [GO:0005737]; endosome [GO:0005768]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; endosome [GO:0005768]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; SH3 domain binding [GO:0017124]; regulation of endocytosis [GO:0030100]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8WXA8	reviewed	5HT3C_HUMAN	5-hydroxytryptamine receptor 3C (5-HT3-C) (5-HT3C) (Serotonin receptor 3C)	HTR3C	Homo sapiens (Human)	447	FUNCTION: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. {ECO:0000269|PubMed:17392525}.		inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; serotonin-gated monoatomic cation-selective channel activity [GO:0022850]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; serotonin-gated monoatomic cation-selective channel activity [GO:0022850]; inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:17392525}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:17392525}; Multi-pass membrane protein {ECO:0000255}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. {ECO:0000269|PubMed:17392525}.
Q8WXA9	reviewed	SREK1_HUMAN	Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508)	SREK1 SFRS12 SRRP86	Homo sapiens (Human)	508	FUNCTION: Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). {ECO:0000250}.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus.
Q8WXB1	reviewed	MT21A_HUMAN	Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (HSPA lysine methyltransferase) (HSPA-KMT) (Hepatocellular carcinoma-associated antigen 557b) (Methyltransferase-like protein 21A)	METTL21A FAM119A HCA557B	Homo sapiens (Human)	218	FUNCTION: Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8. {ECO:0000269|PubMed:22948820, ECO:0000269|PubMed:23349634, ECO:0000269|PubMed:23921388}.		peptidyl-lysine methylation [GO:0018022]; protein methylation [GO:0006479]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	ATPase binding [GO:0051117]; heat shock protein binding [GO:0031072]; histone methyltransferase activity [GO:0042054]; Hsp70 protein binding [GO:0030544]; protein methyltransferase activity [GO:0008276]; protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ATPase binding [GO:0051117]; heat shock protein binding [GO:0031072]; histone methyltransferase activity [GO:0042054]; Hsp70 protein binding [GO:0030544]; protein methyltransferase activity [GO:0008276]; protein-lysine N-methyltransferase activity [GO:0016279]; peptidyl-lysine methylation [GO:0018022]; protein methylation [GO:0006479]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23349634}.
Q8WXC3	reviewed	PYDC1_HUMAN	Pyrin domain-containing protein 1 (PAAD-only protein 1) (Pyrin-only protein 1) (cellular POP1) (cPOP1)	PYDC1 ASC2 ASCI POP1 PYC1	Homo sapiens (Human)	89	FUNCTION: Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. {ECO:0000269|PubMed:12656673, ECO:0000269|PubMed:24871464}.		innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of interleukin-1 beta production [GO:0032731]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; nucleus [GO:0005634]		cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; nucleus [GO:0005634]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of interleukin-1 beta production [GO:0032731]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12656673}. Note=Recruited to specks formed by PYCARD within the cytoplasm. {ECO:0000269|PubMed:17178784}.
Q8WXC6	reviewed	CSN9_HUMAN	COP9 signalosome complex subunit 9 (CSN acidic protein) (CSNAP) (Myeloma-overexpressed gene 2 protein)	COPS9 MYEOV2	Homo sapiens (Human)	57	FUNCTION: [Isoform 1]: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation. {ECO:0000269|PubMed:26456823}.; FUNCTION: [Isoform 2]: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11. {ECO:0000269|PubMed:23776465}.		cellular response to UV [GO:0034644]; cytoplasmic sequestering of protein [GO:0051220]; negative regulation of protein neddylation [GO:2000435]; positive regulation of cell population proliferation [GO:0008284]	chromatin [GO:0000785]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		chromatin [GO:0000785]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cellular response to UV [GO:0034644]; cytoplasmic sequestering of protein [GO:0051220]; negative regulation of protein neddylation [GO:2000435]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:26456823}. Cytoplasm {ECO:0000269|PubMed:26456823}. Nucleus, nucleoplasm {ECO:0000269|PubMed:26456823}. Note=Excluded from the nucleolus. Recruited to the nucleoplasm and chromatin following DNA damage induction. {ECO:0000269|PubMed:26456823}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, nucleoplasm {ECO:0000269|PubMed:23776465}. Note=Excluded from the nucleolus. {ECO:0000269|PubMed:23776465}.
Q8WXD0	reviewed	RXFP2_HUMAN	Relaxin receptor 2 (G-protein coupled receptor 106) (G-protein coupled receptor affecting testicular descent) (Leucine-rich repeat-containing G-protein coupled receptor 8) (Relaxin family peptide receptor 2)	RXFP2 GPR106 GREAT LGR8	Homo sapiens (Human)	754	FUNCTION: Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; oocyte maturation [GO:0001556]; positive regulation of cAMP-mediated signaling [GO:0043950]	plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; protein-hormone receptor activity [GO:0016500]	plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; protein-hormone receptor activity [GO:0016500]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; oocyte maturation [GO:0001556]; positive regulation of cAMP-mediated signaling [GO:0043950]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8WXD2	reviewed	SCG3_HUMAN	Secretogranin-3 (Secretogranin III) (SgIII)	SCG3 UNQ2502/PRO5990	Homo sapiens (Human)	468	FUNCTION: Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827). {ECO:0000250|UniProtKB:P47868, ECO:0000269|PubMed:19357184, ECO:0000269|PubMed:29154827}.		protein localization to secretory granule [GO:0033366]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; secretory granule lumen [GO:0034774]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]	RNA binding [GO:0003723]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; secretory granule lumen [GO:0034774]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]; RNA binding [GO:0003723]; protein localization to secretory granule [GO:0033366]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P47868}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P47868}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000269|PubMed:12098761, ECO:0000269|PubMed:25326458}. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts. {ECO:0000250|UniProtKB:P47868}.
Q8WXD5	reviewed	GEMI6_HUMAN	Gem-associated protein 6 (Gemin-6) (SIP2)	GEMIN6	Homo sapiens (Human)	167	FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:11748230, ECO:0000269|PubMed:18984161}.		mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:11748230}. Nucleus, gem {ECO:0000269|PubMed:11748230}. Cytoplasm {ECO:0000269|PubMed:11748230}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Q8WXE1	reviewed	ATRIP_HUMAN	ATR-interacting protein (ATM and Rad3-related-interacting protein)	ATRIP AGS1	Homo sapiens (Human)	791	FUNCTION: Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}.		DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; nucleobase-containing compound metabolic process [GO:0006139]; regulation of double-strand break repair [GO:2000779]	ATR-ATRIP complex [GO:0070310]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]	ATR-ATRIP complex [GO:0070310]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; nucleobase-containing compound metabolic process [GO:0006139]; regulation of double-strand break repair [GO:2000779]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:18283122}. Note=Redistributes to discrete nuclear foci upon DNA damage.
Q8WXE9	reviewed	STON2_HUMAN	Stonin-2 (Stoned B)	STON2 STN2 STNB	Homo sapiens (Human)	905	FUNCTION: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}.		clathrin-dependent endocytosis [GO:0072583]; regulation of endocytosis [GO:0030100]; synaptic vesicle endocytosis [GO:0048488]	AP-2 adaptor complex [GO:0030122]; cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; synaptic vesicle [GO:0008021]	clathrin adaptor activity [GO:0035615]	AP-2 adaptor complex [GO:0030122]; cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; synaptic vesicle [GO:0008021]; clathrin adaptor activity [GO:0035615]; clathrin-dependent endocytosis [GO:0072583]; regulation of endocytosis [GO:0030100]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11381094}. Membrane {ECO:0000269|PubMed:11381094}. Synapse, synaptosome {ECO:0000250}. Note=Some fraction is membrane-associated.
Q8WXF0	reviewed	SRS12_HUMAN	Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)	SRSF12 SFRS13B SFRS19 SRRP35	Homo sapiens (Human)	261	FUNCTION: Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation. {ECO:0000269|PubMed:11684676}.		mRNA 5'-splice site recognition [GO:0000395]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; spliceosomal tri-snRNP complex assembly [GO:0000244]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]; RS domain binding [GO:0050733]; unfolded protein binding [GO:0051082]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; RS domain binding [GO:0050733]; unfolded protein binding [GO:0051082]; mRNA 5'-splice site recognition [GO:0000395]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; spliceosomal tri-snRNP complex assembly [GO:0000244]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8WXF1	reviewed	PSPC1_HUMAN	Paraspeckle component 1 (Paraspeckle protein 1)	PSPC1 PSP1	Homo sapiens (Human)	523	FUNCTION: Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. {ECO:0000250|UniProtKB:Q8R326, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}.		activation of innate immune response [GO:0002218]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; rhythmic process [GO:0048511]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; RNA binding [GO:0003723]; activation of innate immune response [GO:0002218]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus matrix {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus speckle. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.
Q8WXF3	reviewed	REL3_HUMAN	Relaxin-3 (Insulin-like peptide INSL7) (Insulin-like peptide 7) (Prorelaxin H3) [Cleaved into: Relaxin-3 B chain; Relaxin-3 A chain]	RLN3 INSL7 RXN3 ZINS4 UNQ6188/PRO20213	Homo sapiens (Human)	142	FUNCTION: May play a role in neuropeptide signaling processes. Ligand for LGR7, RXFP3 and RXFP4.			extracellular region [GO:0005576]	G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]	extracellular region [GO:0005576]; G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]	SUBCELLULAR LOCATION: Secreted.
Q8WXF7	reviewed	ATLA1_HUMAN	Atlastin-1 (EC 3.6.5.-) (Brain-specific GTP-binding protein) (GTP-binding protein 3) (GBP-3) (hGBP3) (Guanine nucleotide-binding protein 3) (Spastic paraplegia 3 protein A)	ATL1 GBP3 SPG3A	Homo sapiens (Human)	558	FUNCTION: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:27619977). May also regulate Golgi biogenesis. May regulate axonal development. {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:21220294, ECO:0000269|PubMed:23334294, ECO:0000269|PubMed:25751282, ECO:0000269|PubMed:27619977}.		axonogenesis [GO:0007409]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; protein homooligomerization [GO:0051260]	axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]	axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; axonogenesis [GO:0007409]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:16339213, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:27619977}; Multi-pass membrane protein {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:16339213, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:19665976}. Golgi apparatus membrane {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752}; Multi-pass membrane protein {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752}. Cell projection, axon {ECO:0000250|UniProtKB:Q6PST4}. Note=Localizes to endoplasmic reticulum tubular network (PubMed:27619977). {ECO:0000269|PubMed:27619977}.
Q8WXF8	reviewed	DEDD2_HUMAN	DNA-binding death effector domain-containing protein 2 (DED-containing protein FLAME-3) (FADD-like anti-apoptotic molecule 3)	DEDD2 FLAME3 PSEC0004	Homo sapiens (Human)	326	FUNCTION: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.		apoptotic nuclear changes [GO:0030262]; cellular homeostasis [GO:0019725]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; signaling receptor complex adaptor activity [GO:0030159]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; signaling receptor complex adaptor activity [GO:0030159]; apoptotic nuclear changes [GO:0030262]; cellular homeostasis [GO:0019725]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11965497}. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.
Q8WXG1	reviewed	RSAD2_HUMAN	S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (SAND) (EC 4.2.-.-) (Cytomegalovirus-induced gene 5 protein) (Radical S-adenosyl methionine domain-containing protein 2) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) (Viperin)	RSAD2 CIG5	Homo sapiens (Human)	361	FUNCTION: Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon (PubMed:31812350). Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism (PubMed:29925952, PubMed:30872404). In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication (PubMed:29925952). Therefore, inhibits a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), zika virus, and human immunodeficiency virus (HIV-1) (PubMed:29925952, PubMed:30587778, PubMed:31921110, PubMed:30934824). Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6 (PubMed:30872404). Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. {ECO:0000269|PubMed:11752458, ECO:0000269|PubMed:16108059, ECO:0000269|PubMed:16982913, ECO:0000269|PubMed:17686841, ECO:0000269|PubMed:18005719, ECO:0000269|PubMed:19074433, ECO:0000269|PubMed:29925952, ECO:0000269|PubMed:30587778, ECO:0000269|PubMed:30872404, ECO:0000269|PubMed:30934824, ECO:0000269|PubMed:31812350, ECO:0000269|PubMed:31921110}.	MISCELLANEOUS: Up-regulated in atherosclerosis. Latent viruses like HCMV may be involved in atherogenesis by initiating local inflammation. This may induce up-regulation of antiviral gene RSAD2, which modulates lipids synthesis, and thus could play a role in abnormal lipid accumulation leading to atherosclerosis.	CD4-positive, alpha-beta T cell activation [GO:0035710]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of protein secretion [GO:0050709]; negative regulation of viral genome replication [GO:0045071]; positive regulation of immune response [GO:0050778]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; response to virus [GO:0009615]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	4 iron, 4 sulfur cluster binding [GO:0051539]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]; protein self-association [GO:0043621]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; 4 iron, 4 sulfur cluster binding [GO:0051539]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]; protein self-association [GO:0043621]; CD4-positive, alpha-beta T cell activation [GO:0035710]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of protein secretion [GO:0050709]; negative regulation of viral genome replication [GO:0045071]; positive regulation of immune response [GO:0050778]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus {ECO:0000269|PubMed:11752458, ECO:0000269|PubMed:16982913, ECO:0000269|PubMed:31921110}. Endoplasmic reticulum {ECO:0000269|PubMed:11752458, ECO:0000269|PubMed:16982913, ECO:0000269|PubMed:30587778}. Lipid droplet {ECO:0000269|PubMed:31921110}. Mitochondrion. Mitochondrion inner membrane. Mitochondrion outer membrane. Note=Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28. Interaction with human cytomegalovirus/HHV-5 protein vMIA/UL37 results in its relocalization from the endoplasmic reticulum to the mitochondria.
Q8WXG6	reviewed	MADD_HUMAN	MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP)	MADD DENN IG20 KIAA0358	Homo sapiens (Human)	1647	FUNCTION: Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:20937701, PubMed:18559336). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:20937701, PubMed:18559336). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}.	MISCELLANEOUS: Overexpression of MADD activates the mitogen-activated protein (MAP) kinase extracellular signal-regulated kinase (ERK). Expression of the MADD death domain stimulates both the ERK and c-JUN N-terminal kinase MAP kinases and induces the phosphorylation of cytosolic phospholipase A2. {ECO:0000269|PubMed:9115275}.	cell surface receptor signaling pathway [GO:0007166]; execution phase of apoptosis [GO:0097194]; positive regulation of MAPK cascade [GO:0043410]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Rab protein signal transduction [GO:0032483]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	death receptor binding [GO:0005123]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase activator activity [GO:0030295]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; death receptor binding [GO:0005123]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase activator activity [GO:0030295]; cell surface receptor signaling pathway [GO:0007166]; execution phase of apoptosis [GO:0097194]; positive regulation of MAPK cascade [GO:0043410]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Rab protein signal transduction [GO:0032483]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8988362}. Cytoplasm {ECO:0000269|PubMed:8988362}. Cell projection, axon {ECO:0000250|UniProtKB:Q80U28}.
Q8WXG8	reviewed	S100Z_HUMAN	Protein S100-Z (S100 calcium-binding protein Z)	S100Z	Homo sapiens (Human)	99					calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]	
Q8WXG9	reviewed	AGRV1_HUMAN	Adhesion G-protein coupled receptor V1 (ADGRV1) (EC 3.4.-.-) (G-protein coupled receptor 98) (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Usher syndrome type-2C protein) (Very large G-protein coupled receptor 1) [Cleaved into: ADGRV1 subunit alpha; ADGRV1 subunit beta]	ADGRV1 GPR98 KIAA0686 KIAA1943 MASS1 VLGR1	Homo sapiens (Human)	6306	FUNCTION: G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism. {ECO:0000250|UniProtKB:Q8VHN7}.; FUNCTION: [ADGRV1 subunit beta]: Cleaved ADGRV1 beta-subunit couples with G-alpha(i)-proteins, GNAI1/2/3, and constitutively inhibits adenylate cyclase (AC) activity with a stronger effect than full ADGRV1. {ECO:0000250|UniProtKB:Q8VHN7}.	MISCELLANEOUS: By far is the largest known cell surface protein.; MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Dubious isoform produced through aberrant splice sites. {ECO:0000305|PubMed:11606593}.; MISCELLANEOUS: [Isoform 4]: May be due to intron retention. {ECO:0000305}.	cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cellular response to calcium ion [GO:0071277]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of protein localization [GO:0045184]; G protein-coupled receptor signaling pathway [GO:0007186]; inner ear development [GO:0048839]; inner ear receptor cell differentiation [GO:0060113]; inner ear receptor cell stereocilium organization [GO:0060122]; maintenance of animal organ identity [GO:0048496]; negative regulation of adenylate cyclase activity [GO:0007194]; nervous system development [GO:0007399]; nervous system process [GO:0050877]; photoreceptor cell maintenance [GO:0045494]; positive regulation of bone mineralization [GO:0030501]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein kinase C signaling [GO:0090037]; regulation of protein stability [GO:0031647]; self proteolysis [GO:0097264]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; periciliary membrane compartment [GO:1990075]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	adenylate cyclase inhibitor activity [GO:0010855]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; hydrolase activity [GO:0016787]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; periciliary membrane compartment [GO:1990075]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]; adenylate cyclase inhibitor activity [GO:0010855]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; hydrolase activity [GO:0016787]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cellular response to calcium ion [GO:0071277]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of protein localization [GO:0045184]; G protein-coupled receptor signaling pathway [GO:0007186]; inner ear development [GO:0048839]; inner ear receptor cell differentiation [GO:0060113]; inner ear receptor cell stereocilium organization [GO:0060122]; maintenance of animal organ identity [GO:0048496]; negative regulation of adenylate cyclase activity [GO:0007194]; nervous system development [GO:0007399]; nervous system process [GO:0050877]; photoreceptor cell maintenance [GO:0045494]; positive regulation of bone mineralization [GO:0030501]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein kinase C signaling [GO:0090037]; regulation of protein stability [GO:0031647]; self proteolysis [GO:0097264]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VHN7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8VHN7}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q8VHN7}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8VHN7}. Note=Localizes at the ankle region of the stereocilia. In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex. {ECO:0000250|UniProtKB:Q8VHN7}.
Q8WXH0	reviewed	SYNE2_HUMAN	Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2)	SYNE2 KIAA1011 NUA	Homo sapiens (Human)	6885	FUNCTION: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}.	MISCELLANEOUS: [Isoform 3]: Produced by exon skipping that results in a frameshift. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Lacks the spectrin repeats and KASH domain. {ECO:0000305}.; MISCELLANEOUS: [Isoform 13]: Detected only in ovary and early embryonic cells. {ECO:0000269|PubMed:24718612}.	centrosome localization [GO:0051642]; nuclear migration [GO:0007097]; nuclear migration along microfilament [GO:0031022]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; positive regulation of cell migration [GO:0030335]; regulation of cilium assembly [GO:1902017]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium membrane [GO:0031258]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear lumen [GO:0031981]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018]	actin binding [GO:0003779]; cytoskeleton-nuclear membrane anchor activity [GO:0140444]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium membrane [GO:0031258]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear lumen [GO:0031981]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018]; actin binding [GO:0003779]; cytoskeleton-nuclear membrane anchor activity [GO:0140444]; centrosome localization [GO:0051642]; nuclear migration [GO:0007097]; nuclear migration along microfilament [GO:0031022]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; positive regulation of cell migration [GO:0030335]; regulation of cilium assembly [GO:1902017]	SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Sarcoplasmic reticulum membrane {ECO:0000305|PubMed:15671068}; Single-pass type IV membrane protein {ECO:0000305}. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton. Mitochondrion. Nucleus, nucleoplasm. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000305|PubMed:15671068}. Note=Different isoform patterns are found in the different compartments of the cell. The isoforms having the C-terminal transmembrane span can be found in several organellar membranes like the nuclear envelope, the sarcoplasmic reticulum of myoblasts, or the lamellipodia and focal adhesions at the cell membrane. The largest part of the outer nuclear membrane-associated protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. Remains associated with the nuclear envelope during its breakdown in mitotic cells. Shorter soluble isoforms can be found in the cytoplasm and within the nucleus.; SUBCELLULAR LOCATION: [Isoform 8]: Cell junction, focal adhesion {ECO:0000269|PubMed:22768332}. Note=In U2OS cells. {ECO:0000269|PubMed:22768332}.
Q8WXH2	reviewed	JPH3_HUMAN	Junctophilin-3 (JP-3) (Junctophilin type 3) (Trinucleotide repeat-containing gene 22 protein)	JPH3 JP3 TNRC22	Homo sapiens (Human)	748	FUNCTION: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.		calcium ion transport into cytosol [GO:0060402]; exploration behavior [GO:0035640]; learning [GO:0007612]; locomotion [GO:0040011]; memory [GO:0007613]; neuromuscular process controlling balance [GO:0050885]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of synaptic plasticity [GO:0048167]	endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; membrane [GO:0016020]; plasma membrane [GO:0005886]		endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion transport into cytosol [GO:0060402]; exploration behavior [GO:0035640]; learning [GO:0007612]; locomotion [GO:0040011]; memory [GO:0007613]; neuromuscular process controlling balance [GO:0050885]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of synaptic plasticity [GO:0048167]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). {ECO:0000250}.
Q8WXH5	reviewed	SOCS4_HUMAN	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)	SOCS4 SOCS7	Homo sapiens (Human)	440	FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. {ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:17997974}.		intracellular signal transduction [GO:0035556]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]	phosphatidylinositol 3-kinase complex [GO:0005942]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]	phosphatidylinositol 3-kinase complex [GO:0005942]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; intracellular signal transduction [GO:0035556]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]	
Q8WXI2	reviewed	CNKR2_HUMAN	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2)	CNKSR2 CNK2 KIAA0902 KSR2	Homo sapiens (Human)	1034	FUNCTION: May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269|PubMed:14597674}.		intracellular signal transduction [GO:0035556]; postsynapse organization [GO:0099173]; regulation of signal transduction [GO:0009966]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; intracellular signal transduction [GO:0035556]; postsynapse organization [GO:0099173]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein.
Q8WXI3	reviewed	ASB10_HUMAN	Ankyrin repeat and SOCS box protein 10 (ASB-10)	ASB10	Homo sapiens (Human)	467	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22156576}. Nucleus {ECO:0000269|PubMed:22156576}. Note=In the ciliary body, it is detected in the cytoplasm and perinuclear region of the pigmented ciliary epithelial layer. In the retina, it is detected in the nuclei of retinal ganglion cells.
Q8WXI4	reviewed	ACO11_HUMAN	Acyl-coenzyme A thioesterase 11 (Acyl-CoA thioesterase 11) (EC 3.1.2.-) (Acyl-CoA thioester hydrolase 11) (Adipose-associated thioesterase) (Brown fat-inducible thioesterase) (BFIT) (Palmitoyl-coenzyme A thioesterase) (EC 3.1.2.2)	ACOT11 BFIT KIAA0707 THEA	Homo sapiens (Human)	607	FUNCTION: Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway. {ECO:0000269|PubMed:22897136}.		acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]; intracellular signal transduction [GO:0035556]; negative regulation of cold-induced thermogenesis [GO:0120163]; response to cold [GO:0009409]; response to temperature stimulus [GO:0009266]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]	acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; lipid binding [GO:0008289]; long-chain acyl-CoA hydrolase activity [GO:0052816]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; lipid binding [GO:0008289]; long-chain acyl-CoA hydrolase activity [GO:0052816]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]; intracellular signal transduction [GO:0035556]; negative regulation of cold-induced thermogenesis [GO:0120163]; response to cold [GO:0009409]; response to temperature stimulus [GO:0009266]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:22897136}. Cytoplasm {ECO:0000269|PubMed:22897136}.
Q8WXI7	reviewed	MUC16_HUMAN	Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125)	MUC16 CA125	Homo sapiens (Human)	14507	FUNCTION: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}.	MISCELLANEOUS: Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening.	cell adhesion [GO:0007155]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; vesicle [GO:0031982]		external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
Q8WXI8	reviewed	CLC4D_HUMAN	C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) (Dendritic cell-associated C-type lectin 3) (DC-associated C-type lectin 3) (Dectin-3) (CD antigen CD368)	CLEC4D CLECSF8 MCL	Homo sapiens (Human)	215	FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:23602766, PubMed:23911656). The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed:23602766, PubMed:23911656). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766, PubMed:23911656). The heterodimer formed with CLEC6A is active against fungal infection (PubMed:23911656). Functions as an endocytic receptor (PubMed:14971047). May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (PubMed:14971047). {ECO:0000250|UniProtKB:Q69FH1, ECO:0000269|PubMed:14971047, ECO:0000269|PubMed:23602766, ECO:0000269|PubMed:23911656}.		adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; defense response to bacterium [GO:0042742]; Fc-gamma receptor signaling pathway [GO:0038094]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of myeloid dendritic cell activation [GO:0030887]; T cell differentiation involved in immune response [GO:0002292]	external side of plasma membrane [GO:0009897]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	carbohydrate binding [GO:0030246]; immunoglobulin receptor binding [GO:0034987]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187]	external side of plasma membrane [GO:0009897]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; carbohydrate binding [GO:0030246]; immunoglobulin receptor binding [GO:0034987]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187]; adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; defense response to bacterium [GO:0042742]; Fc-gamma receptor signaling pathway [GO:0038094]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of myeloid dendritic cell activation [GO:0030887]; T cell differentiation involved in immune response [GO:0002292]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23911656}; Single-pass type II membrane protein {ECO:0000305}.
Q8WXI9	reviewed	P66B_HUMAN	Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)	GATAD2B KIAA1150	Homo sapiens (Human)	593	FUNCTION: Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}.		chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]	sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}. Nucleus {ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Chromosome {ECO:0000269|PubMed:27732854}. Note=Speckled nuclear localization requires both CR1 and CR2 regions (PubMed:16415179). Localizes to sites of DNA damage (PubMed:27732854). {ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:27732854}.
Q8WXK1	reviewed	ASB15_HUMAN	Ankyrin repeat and SOCS box protein 15 (ASB-15)	ASB15	Homo sapiens (Human)	588	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		Golgi to lysosome transport [GO:0090160]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; endosome membrane [GO:0010008]	small GTPase binding [GO:0031267]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; small GTPase binding [GO:0031267]; Golgi to lysosome transport [GO:0090160]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]; retrograde transport, endosome to Golgi [GO:0042147]	
Q8WXK3	reviewed	ASB13_HUMAN	Ankyrin repeat and SOCS box protein 13 (ASB-13)	ASB13	Homo sapiens (Human)	278	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]		cytosol [GO:0005829]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	
Q8WXK4	reviewed	ASB12_HUMAN	Ankyrin repeat and SOCS box protein 12 (ASB-12)	ASB12	Homo sapiens (Human)	309	FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250, ECO:0000269|PubMed:16325183}.		protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]		cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]; protein ubiquitination [GO:0016567]	
Q8WXR4	reviewed	MYO3B_HUMAN	Myosin-IIIb (EC 2.7.11.1)	MYO3B	Homo sapiens (Human)	1341	FUNCTION: Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. {ECO:0000250|UniProtKB:Q1EG27}.		cochlea morphogenesis [GO:0090103]; phosphorylation [GO:0016310]; positive regulation of filopodium assembly [GO:0051491]; regulation of actin filament length [GO:0030832]; response to stimulus [GO:0050896]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; filopodium tip [GO:0032433]; myosin complex [GO:0016459]; photoreceptor inner segment [GO:0001917]; stereocilium tip [GO:0032426]	actin binding [GO:0003779]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; filopodium tip [GO:0032433]; myosin complex [GO:0016459]; photoreceptor inner segment [GO:0001917]; stereocilium tip [GO:0032426]; actin binding [GO:0003779]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cochlea morphogenesis [GO:0090103]; phosphorylation [GO:0016310]; positive regulation of filopodium assembly [GO:0051491]; regulation of actin filament length [GO:0030832]; response to stimulus [GO:0050896]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q1EG27}.
Q8WXS3	reviewed	BAALC_HUMAN	Brain and acute leukemia cytoplasmic protein	BAALC	Homo sapiens (Human)	145	FUNCTION: May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A. {ECO:0000250|UniProtKB:Q920K5}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; sarcoplasm [GO:0016528]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; sarcoplasm [GO:0016528]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11707601}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q920K5}. Membrane raft {ECO:0000250|UniProtKB:Q920K5}. Postsynaptic density {ECO:0000250|UniProtKB:Q920K5}. Note=In neurons, localizes to postsynaptic lipid rafts (By similarity). In myocardial and skeletal muscle cells, localizes to the cytoplasm adjacent to the inner cell membrane, polarized to one end of the myocyte (By similarity). {ECO:0000250|UniProtKB:Q8VHV1, ECO:0000250|UniProtKB:Q920K5}.
Q8WXS5	reviewed	CCG8_HUMAN	Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8)	CACNG8 CACNG6	Homo sapiens (Human)	425	FUNCTION: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. {ECO:0000250|UniProtKB:Q8VHW2, ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611}.		calcium ion transport [GO:0006816]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA receptor activity [GO:2000311]; regulation of monoatomic ion transmembrane transport [GO:0034765]; transmission of nerve impulse [GO:0019226]	AMPA glutamate receptor complex [GO:0032281]; endocytic vesicle membrane [GO:0030666]; L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; voltage-gated calcium channel complex [GO:0005891]	calcium channel regulator activity [GO:0005246]; channel regulator activity [GO:0016247]; voltage-gated calcium channel activity [GO:0005245]	AMPA glutamate receptor complex [GO:0032281]; endocytic vesicle membrane [GO:0030666]; L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; voltage-gated calcium channel complex [GO:0005891]; calcium channel regulator activity [GO:0005246]; channel regulator activity [GO:0016247]; voltage-gated calcium channel activity [GO:0005245]; calcium ion transport [GO:0006816]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA receptor activity [GO:2000311]; regulation of monoatomic ion transmembrane transport [GO:0034765]; transmission of nerve impulse [GO:0019226]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VHW2}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q8VHW2}.
Q8WXS8	reviewed	ATS14_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAM-TS 14) (ADAM-TS14) (ADAMTS-14) (EC 3.4.24.-)	ADAMTS14	Homo sapiens (Human)	1223	FUNCTION: Has aminoprocollagen type I processing activity in the absence of ADAMTS2 (PubMed:11741898). Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (PubMed:11741898). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form (PubMed:31152061). {ECO:0000269|PubMed:11741898, ECO:0000269|PubMed:31152061}.	MISCELLANEOUS: [Isoform A]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform B]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform C]: Produced by alternative splicing of isoform B. {ECO:0000305}.; MISCELLANEOUS: [Isoform D]: Produced by alternative splicing of isoform A. {ECO:0000305}.	collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q8WXU2	reviewed	DAAF4_HUMAN	Dynein axonemal assembly factor 4 (Dyslexia susceptibility 1 candidate gene 1 protein)	DNAAF4 DYX1C1 EKN1	Homo sapiens (Human)	420	FUNCTION: Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. {ECO:0000269|PubMed:19423554, ECO:0000269|PubMed:23872636}.		cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; heart development [GO:0007507]; inner dynein arm assembly [GO:0036159]; learning or memory [GO:0007611]; neuron migration [GO:0001764]; outer dynein arm assembly [GO:0036158]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of proteasomal protein catabolic process [GO:0061136]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	nuclear estrogen receptor binding [GO:0030331]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; nuclear estrogen receptor binding [GO:0030331]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; heart development [GO:0007507]; inner dynein arm assembly [GO:0036159]; learning or memory [GO:0007611]; neuron migration [GO:0001764]; outer dynein arm assembly [GO:0036158]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of proteasomal protein catabolic process [GO:0061136]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12954984, ECO:0000269|PubMed:16989952}. Cytoplasm {ECO:0000269|PubMed:12954984, ECO:0000269|PubMed:16989952, ECO:0000269|PubMed:23872636}. Dynein axonemal particle {ECO:0000305|PubMed:23872636}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q5VJS5}.
Q8WXW3	reviewed	PIBF1_HUMAN	Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90)	PIBF1 C13orf24 PIBF	Homo sapiens (Human)	757	FUNCTION: Plays a role in ciliogenesis. {ECO:0000269|PubMed:26167768}.; FUNCTION: [Isoform 1]: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211, ECO:0000269|PubMed:26297806}.; FUNCTION: [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect (PubMed:14634107, PubMed:3863495, PubMed:12516630). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441). {ECO:0000269|PubMed:12516630, ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:16393965, ECO:0000269|PubMed:25218441, ECO:0000269|PubMed:3863495, ECO:0000305|PubMed:11407300}.	MISCELLANEOUS: During normal pregnancy, the production is continuously increasing until the 37th gestational week and is followed by a sharp decrease after the 41st week of gestation. In pathological pregnancies, urinary levels fail to increase. Candidate for the diagnosis of threatened premature pregnancy termination. {ECO:0000305|PubMed:15269099}.	activation of Janus kinase activity [GO:0042976]; cilium assembly [GO:0060271]; immune system process [GO:0002376]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of prostaglandin biosynthetic process [GO:0031393]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; non-motile cilium assembly [GO:1905515]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein localization to centrosome [GO:0071539]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]	interleukin-4 receptor binding [GO:0005136]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; interleukin-4 receptor binding [GO:0005136]; activation of Janus kinase activity [GO:0042976]; cilium assembly [GO:0060271]; immune system process [GO:0002376]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of prostaglandin biosynthetic process [GO:0031393]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; non-motile cilium assembly [GO:1905515]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein localization to centrosome [GO:0071539]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm {ECO:0000269|PubMed:25218441}. Secreted {ECO:0000269|PubMed:25218441}. Note=In progesterone-treated astrocytoma cells a 57 kDa protein and isoform 1 (90 kDa) have been described, both being located in the intracellular medium and secreted. Respective predominant forms are isoform 1 in the intracellular and the 57 kDa protein in the extracellular medium (PubMed:25218441). {ECO:0000269|PubMed:25218441}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:25218441}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15305375}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:26297806}. Secreted {ECO:0000269|PubMed:25218441}. Note=Localizes to centriolar satellites throughout the cell cycle. {ECO:0000269|PubMed:26297806}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:3863495}. Note=Secreted by progesterone-treated lymphocytes (PubMed:14634107). {ECO:0000269|PubMed:14634107}.
Q8WXX0	reviewed	DYH7_HUMAN	Dynein axonemal heavy chain 7 (Axonemal beta dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (hDHC2)	DNAH7 KIAA0944	Homo sapiens (Human)	4024	FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). {ECO:0000250}.		cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; inner dynein arm assembly [GO:0036159]	9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; cilium [GO:0005929]; cytosol [GO:0005829]; inner dynein arm [GO:0036156]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; cilium [GO:0005929]; cytosol [GO:0005829]; inner dynein arm [GO:0036156]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; inner dynein arm assembly [GO:0036159]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:11877439}.
Q8WXX5	reviewed	DNJC9_HUMAN	DnaJ homolog subfamily C member 9 (HDJC9) (DnaJ protein SB73)	DNAJC9	Homo sapiens (Human)	260	FUNCTION: Acts as a dual histone chaperone and heat shock co-chaperone (PubMed:33857403). As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes (PubMed:33857403). May also act as a histone co-chaperone together with TONSL (PubMed:33857403). May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers (PubMed:33857403). Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8 (PubMed:17182002, PubMed:33857403). As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity (PubMed:33857403). Exhibits activity to assemble histones onto DNA in vitro (PubMed:33857403). {ECO:0000269|PubMed:17182002, ECO:0000269|PubMed:33857403}.		nucleosome assembly [GO:0006334]; positive regulation of ATP-dependent activity [GO:0032781]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein folding chaperone complex [GO:0101031]	heat shock protein binding [GO:0031072]; histone binding [GO:0042393]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein folding chaperone complex [GO:0101031]; heat shock protein binding [GO:0031072]; histone binding [GO:0042393]; protein-folding chaperone binding [GO:0051087]; nucleosome assembly [GO:0006334]; positive regulation of ATP-dependent activity [GO:0032781]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17182002}. Cytoplasm {ECO:0000269|PubMed:17182002}. Cell membrane {ECO:0000269|PubMed:17182002}. Note=Predominantly nuclear. Translocates to the cytoplasm and membrane after heat shock. {ECO:0000269|PubMed:17182002}.
Q8WXX7	reviewed	AUTS2_HUMAN	Autism susceptibility gene 2 protein	AUTS2 KIAA0442	Homo sapiens (Human)	1259	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}.		actin cytoskeleton organization [GO:0030036]; axon extension [GO:0048675]; dendrite extension [GO:0097484]; neuron migration [GO:0001764]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of histone H4-K16 acetylation [GO:2000620]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; growth cone [GO:0030426]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; growth cone [GO:0030426]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; actin cytoskeleton organization [GO:0030036]; axon extension [GO:0048675]; dendrite extension [GO:0097484]; neuron migration [GO:0001764]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of histone H4-K16 acetylation [GO:2000620]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25519132}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0A087WPF7}. Cell projection, growth cone {ECO:0000250|UniProtKB:A0A087WPF7}. Note=Detected both in cytoplasm and nucleus. Colocalizes with RAC1 at actin-rich growth cones. Detected on the promoter region of actively transcribed genes. {ECO:0000250|UniProtKB:A0A087WPF7}.
Q8WY07	reviewed	CTR3_HUMAN	Cationic amino acid transporter 3 (CAT-3) (CAT3) (Cationic amino acid transporter y+) (Solute carrier family 7 member 3)	SLC7A3 ATRC3 CAT3	Homo sapiens (Human)	619	FUNCTION: Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:11591158). The transport is sodium ions- and pH-independent, moderately trans-stimulated and is mediated by passive diffusion (PubMed:11591158). {ECO:0000269|PubMed:11591158}.		amino acid transport [GO:0006865]; L-arginine import across plasma membrane [GO:0097638]; L-lysine import across plasma membrane [GO:0097639]; L-ornithine import across plasma membrane [GO:0097640]; L-ornithine transmembrane transport [GO:1903352]; transport across blood-brain barrier [GO:0150104]	plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]	plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]; amino acid transport [GO:0006865]; L-arginine import across plasma membrane [GO:0097638]; L-lysine import across plasma membrane [GO:0097639]; L-ornithine import across plasma membrane [GO:0097640]; L-ornithine transmembrane transport [GO:1903352]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8WY21	reviewed	SORC1_HUMAN	VPS10 domain-containing receptor SorCS1 (hSorCS)	SORCS1 SORCS	Homo sapiens (Human)	1168			neuropeptide signaling pathway [GO:0007218]; post-Golgi vesicle-mediated transport [GO:0006892]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	neuropeptide receptor activity [GO:0008188]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuropeptide receptor activity [GO:0008188]; neuropeptide signaling pathway [GO:0007218]; post-Golgi vesicle-mediated transport [GO:0006892]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q8WY36	reviewed	BBX_HUMAN	HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2)	BBX HBP2	Homo sapiens (Human)	941	FUNCTION: Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}.		bone development [GO:0060348]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; bone development [GO:0060348]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8WY41	reviewed	NANO1_HUMAN	Nanos homolog 1 (NOS-1) (EC_Rep1a)	NANOS1 NOS1	Homo sapiens (Human)	292	FUNCTION: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. {ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680}.		cell migration [GO:0016477]; cerebellar neuron development [GO:0098749]; epithelial cell migration [GO:0010631]; negative regulation of translation [GO:0017148]; oogenesis [GO:0048477]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell growth [GO:0001558]; tissue homeostasis [GO:0001894]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]	mRNA binding [GO:0003729]; translation repressor activity [GO:0030371]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; mRNA binding [GO:0003729]; translation repressor activity [GO:0030371]; zinc ion binding [GO:0008270]; cell migration [GO:0016477]; cerebellar neuron development [GO:0098749]; epithelial cell migration [GO:0010631]; negative regulation of translation [GO:0017148]; oogenesis [GO:0048477]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell growth [GO:0001558]; tissue homeostasis [GO:0001894]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:19168546}. Cytoplasm {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:19168546}. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:19168546}.
Q8WY54	reviewed	PPM1E_HUMAN	Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA)	PPM1E CAMKN KIAA1072 POPX1	Homo sapiens (Human)	755	FUNCTION: Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11864573}.		cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of protein kinase activity [GO:0006469]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of stress fiber assembly [GO:0051496]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of protein kinase activity [GO:0006469]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of stress fiber assembly [GO:0051496]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15496589, ECO:0000269|PubMed:16269004}. Cytoplasm {ECO:0000269|PubMed:15496589, ECO:0000269|PubMed:16269004}. Note=A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full-length, minor form, is found in the nucleus. {ECO:0000269|PubMed:15496589, ECO:0000269|PubMed:16269004}.
Q8WY64	reviewed	MYLIP_HUMAN	E3 ubiquitin-protein ligase MYLIP (EC 2.3.2.27) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) (RING-type E3 ubiquitin transferase MYLIP)	MYLIP BZF1 IDOL BM-023 PP5242	Homo sapiens (Human)	445	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. {ECO:0000269|PubMed:10593918, ECO:0000269|PubMed:12826659, ECO:0000269|PubMed:14550572, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281, ECO:0000269|PubMed:22109552}.		cholesterol homeostasis [GO:0042632]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; positive regulation of protein catabolic process [GO:0045732]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of low-density lipoprotein particle receptor catabolic process [GO:0032803]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cholesterol homeostasis [GO:0042632]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; positive regulation of protein catabolic process [GO:0045732]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of low-density lipoprotein particle receptor catabolic process [GO:0032803]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:14550572}. Cell membrane {ECO:0000269|PubMed:14550572}; Peripheral membrane protein {ECO:0000269|PubMed:14550572}.
Q8WY91	reviewed	THAP4_HUMAN	Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4)	THAP4 CGI-36 PP238	Homo sapiens (Human)	577	FUNCTION: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000269|PubMed:30524950, ECO:0000269|PubMed:32295384}.		nitrate metabolic process [GO:0042126]; tyrosine metabolic process [GO:0006570]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nitric oxide binding [GO:0070026]; peroxynitrite isomerase activity [GO:0062213]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nitric oxide binding [GO:0070026]; peroxynitrite isomerase activity [GO:0062213]; nitrate metabolic process [GO:0042126]; tyrosine metabolic process [GO:0006570]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localizes mainly in the cytoplasm and partially in the nucleus. {ECO:0000269|PubMed:32295384}.
Q8WY98	reviewed	TM234_HUMAN	Transmembrane protein 234	TMEM234 C1orf91 PP1065 UNQ548/PRO1105	Homo sapiens (Human)	164		MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8WYA0	reviewed	IFT81_HUMAN	Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1)	IFT81 CDV1	Homo sapiens (Human)	676	FUNCTION: Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region (PubMed:23990561). Required for ciliogenesis (PubMed:27666822, PubMed:23990561). Required for proper regulation of SHH signaling (PubMed:27666822). Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella (By similarity). {ECO:0000250|UniProtKB:O35594, ECO:0000269|PubMed:23990561, ECO:0000269|PubMed:27666822}.	MISCELLANEOUS: [Isoform CDV-1]: Produced by alternative initiation at Met-570 of isoform CDV-1R. {ECO:0000305}.	cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of smoothened signaling pathway [GO:0008589]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	tubulin binding [GO:0015631]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; tubulin binding [GO:0015631]; cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of smoothened signaling pathway [GO:0008589]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000305|PubMed:23990561}. Cytoplasm {ECO:0000250|UniProtKB:O35594}.
Q8WYA1	reviewed	BMAL2_HUMAN	Basic helix-loop-helix ARNT-like protein 2 (Aryl hydrocarbon receptor nuclear translocator-like protein 2) (Basic-helix-loop-helix-PAS protein MOP9) (Brain and muscle ARNT-like 2) (CYCLE-like factor) (CLIF) (Class E basic helix-loop-helix protein 6) (bHLHe6) (Member of PAS protein 9) (PAS domain-containing protein 9)	BMAL2 ARNTL2 BHLHE6 CLIF MOP9 PASD9	Homo sapiens (Human)	636	FUNCTION: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. {ECO:0000269|PubMed:11018023, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:14672706}.		circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock [GO:0009649]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; CLOCK-BMAL transcription complex [GO:1990513]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; CLOCK-BMAL transcription complex [GO:1990513]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock [GO:0009649]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:10964693}.
Q8WYA6	reviewed	CTBL1_HUMAN	Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (Testis development protein NYD-SP19)	CTNNBL1 C20orf33 PP8304	Homo sapiens (Human)	563	FUNCTION: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies (PubMed:32484799). {ECO:0000269|PubMed:32484799}.		adaptive immune response [GO:0002250]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of apoptotic process [GO:0043065]; somatic diversification of immunoglobulins [GO:0016445]	centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]	enzyme binding [GO:0019899]	centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; enzyme binding [GO:0019899]; adaptive immune response [GO:0002250]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of apoptotic process [GO:0043065]; somatic diversification of immunoglobulins [GO:0016445]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.
Q8WYB5	reviewed	KAT6B_HUMAN	Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor)	KAT6B KIAA0383 MORF MOZ2 MYST4	Homo sapiens (Human)	2073	FUNCTION: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}.		negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]	MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; histone H3K14 acetyltransferase activity [GO:0036408]; metal ion binding [GO:0046872]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; histone H3K14 acetyltransferase activity [GO:0036408]; metal ion binding [GO:0046872]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8WYH8	reviewed	ING5_HUMAN	Inhibitor of growth protein 5 (p28ING5)	ING5	Homo sapiens (Human)	240	FUNCTION: Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). {ECO:0000269|PubMed:12750254, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21750715, ECO:0000269|PubMed:24065767}.		apoptotic signaling pathway [GO:0097190]; DNA replication-dependent chromatin disassembly [GO:0140889]; fibroblast proliferation [GO:0048144]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of growth [GO:0045926]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein acetylation [GO:0006473]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of developmental process [GO:0050793]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]	histone acetyltransferase complex [GO:0000123]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]	histone acetyltransferase complex [GO:0000123]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; apoptotic signaling pathway [GO:0097190]; DNA replication-dependent chromatin disassembly [GO:0140889]; fibroblast proliferation [GO:0048144]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of growth [GO:0045926]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein acetylation [GO:0006473]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of developmental process [GO:0050793]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18794358}. Chromosome {ECO:0000269|PubMed:24065767}. Note=Localizes to transcription start sites. {ECO:0000269|PubMed:24065767}.
Q8WYJ6	reviewed	SEPT1_HUMAN	Septin-1 (LARP) (Peanut-like protein 3) (Serologically defined breast cancer antigen NY-BR-24)	SEPTIN1 DIFF6 PNUTL3 SEPT1	Homo sapiens (Human)	372	FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). {ECO:0000250, ECO:0000305}.		cytoskeleton-dependent cytokinesis [GO:0061640]; meiotic metaphase chromosome alignment [GO:0051311]; regulation of exocytosis [GO:0017157]; spindle assembly involved in female meiosis [GO:0007056]	cell division site [GO:0032153]; meiotic spindle [GO:0072687]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; septin complex [GO:0031105]; septin ring [GO:0005940]; synaptic vesicle [GO:0008021]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]	cell division site [GO:0032153]; meiotic spindle [GO:0072687]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; septin complex [GO:0031105]; septin ring [GO:0005940]; synaptic vesicle [GO:0008021]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; cytoskeleton-dependent cytokinesis [GO:0061640]; meiotic metaphase chromosome alignment [GO:0051311]; regulation of exocytosis [GO:0017157]; spindle assembly involved in female meiosis [GO:0007056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis.
Q8WYK0	reviewed	ACO12_HUMAN	Acetyl-coenzyme A thioesterase (EC 3.1.2.1) (Acyl-CoA thioester hydrolase 12) (Acyl-coenzyme A thioesterase 12) (Acyl-CoA thioesterase 12) (Cytoplasmic acetyl-CoA hydrolase 1) (CACH-1) (hCACH-1) (START domain-containing protein 15) (StARD15)	ACOT12 CACH CACH1 STARD15	Homo sapiens (Human)	555	FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16951743). Preferentially hydrolyzes acetyl-CoA (PubMed:16951743). {ECO:0000269|PubMed:16951743}.		acetyl-CoA metabolic process [GO:0006084]; acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]	acetyl-CoA hydrolase activity [GO:0003986]; acyl-CoA hydrolase activity [GO:0047617]; ATP binding [GO:0005524]; carboxylic ester hydrolase activity [GO:0052689]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; acetyl-CoA hydrolase activity [GO:0003986]; acyl-CoA hydrolase activity [GO:0047617]; ATP binding [GO:0005524]; carboxylic ester hydrolase activity [GO:0052689]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; acetyl-CoA metabolic process [GO:0006084]; acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16951743}.
Q8WYK2	reviewed	JDP2_HUMAN	Jun dimerization protein 2	JDP2	Homo sapiens (Human)	163	FUNCTION: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. {ECO:0000269|PubMed:12707301, ECO:0000269|PubMed:12903123, ECO:0000269|PubMed:16026868, ECO:0000269|PubMed:16518400}.		chromatin remodeling [GO:0006338]; fat cell differentiation [GO:0045444]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	cAMP response element binding [GO:0035497]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone chaperone activity [GO:0140713]; histone deacetylase binding [GO:0042826]; leucine zipper domain binding [GO:0043522]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; cAMP response element binding [GO:0035497]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone chaperone activity [GO:0140713]; histone deacetylase binding [GO:0042826]; leucine zipper domain binding [GO:0043522]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; chromatin remodeling [GO:0006338]; fat cell differentiation [GO:0045444]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8WYL5	reviewed	SSH1_HUMAN	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L)	SSH1 KIAA1298 SSH1L	Homo sapiens (Human)	1049	FUNCTION: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}.	MISCELLANEOUS: Tyrosine phosphatase activity has not been demonstrated for this protein to date.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Due to intron retention. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; cell morphogenesis [GO:0000902]; cellular response to ATP [GO:0071318]; excitatory chemical synaptic transmission [GO:0098976]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of AMPA glutamate receptor clustering [GO:1904719]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; protein dephosphorylation [GO:0006470]; regulation of protein metabolic process [GO:0051246]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; midbody [GO:0030496]; plasma membrane [GO:0005886]; synapse [GO:0045202]	actin binding [GO:0003779]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; midbody [GO:0030496]; plasma membrane [GO:0005886]; synapse [GO:0045202]; actin binding [GO:0003779]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; actin cytoskeleton organization [GO:0030036]; cell morphogenesis [GO:0000902]; cellular response to ATP [GO:0071318]; excitatory chemical synaptic transmission [GO:0098976]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of AMPA glutamate receptor clustering [GO:1904719]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; protein dephosphorylation [GO:0006470]; regulation of protein metabolic process [GO:0051246]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.
Q8WYN0	reviewed	ATG4A_HUMAN	Cysteine protease ATG4A (EC 3.4.22.-) (AUT-like 2 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 2) (Autophagin-2) (Autophagy-related protein 4 homolog A) (HsAPG4A) (hAPG4A)	ATG4A APG4A AUTL2	Homo sapiens (Human)	398	FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15169837, PubMed:12473658, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004, PubMed:32732290). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine (PubMed:15169837, PubMed:12473658, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:15169837, PubMed:12473658, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004). Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP (PubMed:15169837, PubMed:12473658, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004). Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (PubMed:31315929, PubMed:33773106). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:29458288, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:29458288, PubMed:33909989). Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity (PubMed:29458288). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106). {ECO:0000269|PubMed:12473658, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:21245471, ECO:0000269|PubMed:22302004, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:31315929, ECO:0000269|PubMed:32732290, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; lipid metabolic process [GO:0006629]; protein delipidation [GO:0051697]; protein transport [GO:0015031]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]	cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786]	cytoplasm [GO:0005737]; cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; lipid metabolic process [GO:0006629]; protein delipidation [GO:0051697]; protein transport [GO:0015031]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BGE6}.
Q8WYP3	reviewed	RIN2_HUMAN	Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2)	RIN2 RASSF4	Homo sapiens (Human)	895	FUNCTION: Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. {ECO:0000269|PubMed:11733506}.		endocytosis [GO:0006897]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of vasculogenesis [GO:2001214]; small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; endocytic vesicle [GO:0030139]	GTPase activator activity [GO:0005096]; GTPase regulator activity [GO:0030695]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; GTPase activator activity [GO:0005096]; GTPase regulator activity [GO:0030695]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; endocytosis [GO:0006897]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of vasculogenesis [GO:2001214]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8WYP5	reviewed	ELYS_HUMAN	Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1)	AHCTF1 ELYS TMBS62 MSTP108	Homo sapiens (Human)	2266	FUNCTION: Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.		cell cycle [GO:0007049]; cell division [GO:0051301]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; cell cycle [GO:0007049]; cell division [GO:0051301]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8CJF7}. Nucleus {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:27341616}. Nucleus envelope {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:27341616}. Nucleus matrix {ECO:0000269|PubMed:17098863}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:27341616}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17098863}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:17098863}. Note=Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107-160 subcomplex of the NPC. Localizes to the periphery of chromatin from late anaphase. {ECO:0000269|PubMed:17098863}.
Q8WYQ3	reviewed	CHC10_HUMAN	Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (Protein N27C7-4)	CHCHD10 C22orf16	Homo sapiens (Human)	142	FUNCTION: May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. {ECO:0000269|PubMed:24934289}.		maintenance of protein location in nucleus [GO:0051457]; maintenance of synapse structure [GO:0099558]; mitochondria-nucleus signaling pathway [GO:0031930]; mitochondrial nucleoid organization [GO:0090144]; mitochondrion organization [GO:0007005]; oxidative phosphorylation [GO:0006119]; positive regulation of cristae formation [GO:1903852]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of mitochondrial transcription [GO:1903109]; protein-containing complex assembly [GO:0065003]; stabilization of membrane potential [GO:0030322]	MICOS complex [GO:0061617]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]		MICOS complex [GO:0061617]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; maintenance of protein location in nucleus [GO:0051457]; maintenance of synapse structure [GO:0099558]; mitochondria-nucleus signaling pathway [GO:0031930]; mitochondrial nucleoid organization [GO:0090144]; mitochondrion organization [GO:0007005]; oxidative phosphorylation [GO:0006119]; positive regulation of cristae formation [GO:1903852]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of mitochondrial transcription [GO:1903109]; protein-containing complex assembly [GO:0065003]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:24934289}. Note=Enriched at the cristae junctions. {ECO:0000269|PubMed:24934289}.
Q8WYQ5	reviewed	DGCR8_HUMAN	Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)	DGCR8 C22orf12 DGCRK6 LP4941	Homo sapiens (Human)	773	FUNCTION: Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}.		positive regulation of pre-miRNA processing [GO:2000633]; primary miRNA processing [GO:0031053]; regulation of stem cell proliferation [GO:0072091]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; microprocessor complex [GO:0070877]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	double-stranded RNA binding [GO:0003725]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; protein-RNA adaptor activity [GO:0140517]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; microprocessor complex [GO:0070877]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; double-stranded RNA binding [GO:0003725]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; protein-RNA adaptor activity [GO:0140517]; positive regulation of pre-miRNA processing [GO:2000633]; primary miRNA processing [GO:0031053]; regulation of stem cell proliferation [GO:0072091]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:22118463}. Nucleus, nucleolus {ECO:0000269|PubMed:17159994}. Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994).
Q8WYR1	reviewed	PI3R5_HUMAN	Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2) (PtdIns-3-kinase p101) (p101-PI3K)	PIK3R5	Homo sapiens (Human)	880	FUNCTION: Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}.		G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; G-protein beta/gamma-subunit complex binding [GO:0031683]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; G-protein beta/gamma-subunit complex binding [GO:0031683]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O02696}. Cytoplasm {ECO:0000250|UniProtKB:O02696}. Cell membrane {ECO:0000250|UniProtKB:O02696}; Peripheral membrane protein {ECO:0000250|UniProtKB:O02696}. Note=Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner. {ECO:0000250|UniProtKB:O02696}.
Q8WYR4	reviewed	RSPH1_HUMAN	Radial spoke head 1 homolog (Cancer/testis antigen 79) (CT79) (Male meiotic metaphase chromosome-associated acidic protein) (Meichroacidin) (Testis-specific gene A2 protein)	RSPH1 TSA2 TSGA2	Homo sapiens (Human)	309	FUNCTION: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. {ECO:0000269|PubMed:23993197}.		axoneme assembly [GO:0035082]; meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286]	condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; motile cilium [GO:0031514]; nucleus [GO:0005634]; outer dense fiber [GO:0001520]; radial spoke head 1 [GO:0120336]; radial spoke head 3 [GO:0120338]		condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; motile cilium [GO:0031514]; nucleus [GO:0005634]; outer dense fiber [GO:0001520]; radial spoke head 1 [GO:0120336]; radial spoke head 3 [GO:0120338]; axoneme assembly [GO:0035082]; meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8VIG3}. Chromosome {ECO:0000250|UniProtKB:Q8VIG3}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23993197}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q8VIG3}. Note=Cytoplasmic in late spermatocytes, secondary spermatocytes and round spermatids. Gathered around metaphase chromosomes during meiotic divisions. {ECO:0000250|UniProtKB:Q8VIG3}.
Q8WZ04	reviewed	TOMT_HUMAN	Transmembrane O-methyltransferase (EC 2.1.1.6) (Catechol O-methyltransferase 2) (Protein LRTOMT2)	TOMT COMT2 LRTOMT PP7517	Homo sapiens (Human)	291	FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (PubMed:18794526). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity). {ECO:0000250|UniProtKB:A1Y9I9, ECO:0000269|PubMed:18794526}.	MISCELLANEOUS: LRRC51 and TOMT were originally considered as alternative reading frames, LRTOMT1 and LRTOMT2 of the same LRTOMT gene in primates. {ECO:0000303|PubMed:18953341}.	auditory receptor cell development [GO:0060117]; catecholamine catabolic process [GO:0042424]; developmental process [GO:0032502]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; methylation [GO:0032259]; neurotransmitter catabolic process [GO:0042135]; sensory perception of sound [GO:0007605]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	catechol O-methyltransferase activity [GO:0016206]; L-dopa O-methyltransferase activity [GO:0102084]; orcinol O-methyltransferase activity [GO:0102938]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; catechol O-methyltransferase activity [GO:0016206]; L-dopa O-methyltransferase activity [GO:0102084]; orcinol O-methyltransferase activity [GO:0102938]; auditory receptor cell development [GO:0060117]; catecholamine catabolic process [GO:0042424]; developmental process [GO:0032502]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; methylation [GO:0032259]; neurotransmitter catabolic process [GO:0042135]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:28504928}. Endoplasmic reticulum {ECO:0000250|UniProtKB:A1Y9I9}. Note=Localized to the cell body of the cochlear hair cells, but is not present in the stereocilia (PubMed:28504928). Present but not restricted to the apical cistern, Hensen's body and the subsurface cistern (By similarity). {ECO:0000250|UniProtKB:A1Y9I9, ECO:0000269|PubMed:28504928}.
Q8WZ19	reviewed	BACD1_HUMAN	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (hBACURD1) (BTB/POZ domain-containing protein KCTD13) (Polymerase delta-interacting protein 1) (TNFAIP1-like protein)	KCTD13 BACURD1 PDIP1 POLDIP1 FKSG86 PP6832	Homo sapiens (Human)	329	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity). {ECO:0000250|UniProtKB:Q8BGV7, ECO:0000269|PubMed:19782033}.		cell migration [GO:0016477]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of synaptic transmission [GO:0050806]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; stress fiber assembly [GO:0043149]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; cell migration [GO:0016477]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of synaptic transmission [GO:0050806]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; stress fiber assembly [GO:0043149]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11593007}.
Q8WZ42	reviewed	TITIN_HUMAN	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)	TTN	Homo sapiens (Human)	34350	FUNCTION: Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. {ECO:0000269|PubMed:11846417, ECO:0000269|PubMed:9804419}.	MISCELLANEOUS: In some isoforms, after the PEVK repeat region there is a long PEVK duplicated region. On account of this region, it has been very difficult to sequence the whole protein. The length of this region (ranging from 183 to 2174 residues), may be a key elastic element of titin.	cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; phosphorylation [GO:0016310]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein kinase A signaling [GO:0010737]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941]	condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; I band [GO:0031674]; M band [GO:0031430]; striated muscle thin filament [GO:0005865]; Z disc [GO:0030018]	actin filament binding [GO:0051015]; actinin binding [GO:0042805]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; muscle alpha-actinin binding [GO:0051371]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; protein self-association [GO:0043621]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; structural constituent of muscle [GO:0008307]; structural molecule activity conferring elasticity [GO:0097493]; telethonin binding [GO:0031433]	condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; I band [GO:0031674]; M band [GO:0031430]; striated muscle thin filament [GO:0005865]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; actinin binding [GO:0042805]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; muscle alpha-actinin binding [GO:0051371]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; protein self-association [GO:0043621]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; structural constituent of muscle [GO:0008307]; structural molecule activity conferring elasticity [GO:0097493]; telethonin binding [GO:0031433]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; phosphorylation [GO:0016310]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein kinase A signaling [GO:0010737]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:16410549}. Nucleus {ECO:0000269|PubMed:16410549}.
Q8WZ55	reviewed	BSND_HUMAN	Barttin	BSND BART	Homo sapiens (Human)	320	FUNCTION: Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. {ECO:0000269|PubMed:11734858, ECO:0000269|PubMed:12111250}.		chloride transport [GO:0006821]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	chloride channel activity [GO:0005254]; chloride channel regulator activity [GO:0017081]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; chloride channel activity [GO:0005254]; chloride channel regulator activity [GO:0017081]; chloride transport [GO:0006821]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=A significant amount also observed intracellularly. Staining in membranes of the renal tubule and of potassium-secreting epithelia of the inner ear is basolateral (By similarity). {ECO:0000250}.
Q8WZ59	reviewed	TM190_HUMAN	Transmembrane protein 190	TMEM190 MDAC1	Homo sapiens (Human)	177			hematopoietic progenitor cell differentiation [GO:0002244]	inner acrosomal membrane [GO:0002079]; nucleus [GO:0005634]	protein self-association [GO:0043621]	inner acrosomal membrane [GO:0002079]; nucleus [GO:0005634]; protein self-association [GO:0043621]; hematopoietic progenitor cell differentiation [GO:0002244]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q8WZ73	reviewed	RFFL_HUMAN	E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin)	RFFL RNF189 RNF34L	Homo sapiens (Human)	363	FUNCTION: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}.		apoptotic process [GO:0006915]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of fibroblast migration [GO:0010762]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of TOR signaling [GO:0032006]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of fibroblast migration [GO:0010762]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of TOR signaling [GO:0032006]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The FYVE-type zinc finger may mediate phosphatidylinositol phosphate-binding and control subcellular localization.
Q8WZ74	reviewed	CTTB2_HUMAN	Cortactin-binding protein 2 (CortBP2)	CTTNBP2 C7orf8 CORTBP2 KIAA1758	Homo sapiens (Human)	1663	FUNCTION: Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance. {ECO:0000250}.		regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of synapse organization [GO:0050807]	cell cortex [GO:0005938]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; postsynaptic actin cytoskeleton [GO:0098871]; synaptic vesicle [GO:0008021]	SH3 domain binding [GO:0017124]	cell cortex [GO:0005938]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; postsynaptic actin cytoskeleton [GO:0098871]; synaptic vesicle [GO:0008021]; SH3 domain binding [GO:0017124]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of synapse organization [GO:0050807]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Remains associated with dendritic spines even after glutamate stimulation. {ECO:0000250}.
Q8WZ75	reviewed	ROBO4_HUMAN	Roundabout homolog 4 (Magic roundabout)	ROBO4 UNQ421/PRO3674	Homo sapiens (Human)	1007	FUNCTION: Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}.		angiogenesis [GO:0001525]; axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; establishment of endothelial barrier [GO:0061028]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of cell migration [GO:0030334]	axon [GO:0030424]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cell-cell adhesion mediator activity [GO:0098632]; signaling receptor activity [GO:0038023]	axon [GO:0030424]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cell-cell adhesion mediator activity [GO:0098632]; signaling receptor activity [GO:0038023]; angiogenesis [GO:0001525]; axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; establishment of endothelial barrier [GO:0061028]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of cell migration [GO:0030334]	
Q8WZA1	reviewed	PMGT1_HUMAN	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-) (UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2) (GnT I.2)	POMGNT1 MGAT1.2 UNQ746/PRO1475	Homo sapiens (Human)	660	FUNCTION: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins (PubMed:11709191, PubMed:27493216, PubMed:28512129). Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties (PubMed:11709191, PubMed:27493216). Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity. {ECO:0000269|PubMed:11709191, ECO:0000269|PubMed:11742540, ECO:0000269|PubMed:26908613, ECO:0000269|PubMed:27391550, ECO:0000269|PubMed:27493216, ECO:0000269|PubMed:28512129}.		basement membrane organization [GO:0071711]; dentate gyrus development [GO:0021542]; gene expression [GO:0010467]; localization of cell [GO:0051674]; myelination [GO:0042552]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; reactive gliosis [GO:0150103]; sensory perception of sound [GO:0007605]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; manganese ion binding [GO:0030145]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; manganese ion binding [GO:0030145]; basement membrane organization [GO:0071711]; dentate gyrus development [GO:0021542]; gene expression [GO:0010467]; localization of cell [GO:0051674]; myelination [GO:0042552]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; reactive gliosis [GO:0150103]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17034757, ECO:0000303|PubMed:11709191}; Single-pass type II membrane protein {ECO:0000305|PubMed:11709191}.
Q8WZA2	reviewed	RPGF4_HUMAN	Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII)	RAPGEF4 CGEF2 EPAC2	Homo sapiens (Human)	1011	FUNCTION: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:9856955}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage. Promoter analysis was carried out in mouse.; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. Promoter analysis was carried out in mouse. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 1. {ECO:0000305}.	adaptive immune response [GO:0002250]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcium-ion regulated exocytosis [GO:0017156]; G protein-coupled receptor signaling pathway [GO:0007186]; insulin secretion [GO:0030073]; positive regulation of insulin secretion [GO:0032024]; Ras protein signal transduction [GO:0007265]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle cycle [GO:0098693]	cytosol [GO:0005829]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cAMP binding [GO:0030552]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cAMP binding [GO:0030552]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]; adaptive immune response [GO:0002250]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcium-ion regulated exocytosis [GO:0017156]; G protein-coupled receptor signaling pathway [GO:0007186]; insulin secretion [GO:0030073]; positive regulation of insulin secretion [GO:0032024]; Ras protein signal transduction [GO:0007265]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle cycle [GO:0098693]	SUBCELLULAR LOCATION: Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q92185	reviewed	SIA8A_HUMAN	Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.3.8) (Alpha-2,8-sialyltransferase 8A) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Sialyltransferase 8A) (SIAT8-A) (Sialyltransferase St8Sia I) (ST8SiaI)	ST8SIA1 SIAT8 SIAT8A	Homo sapiens (Human)	356	FUNCTION: Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid (PubMed:7937974, PubMed:8058740, PubMed:8195250, PubMed:8631981, PubMed:8706663, PubMed:18348864, PubMed:22885356). Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3 (PubMed:8631981). Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (PubMed:8706663). Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells (PubMed:22885356). {ECO:0000269|PubMed:18348864, ECO:0000269|PubMed:22885356, ECO:0000269|PubMed:7937974, ECO:0000269|PubMed:8058740, ECO:0000269|PubMed:8195250, ECO:0000269|PubMed:8631981, ECO:0000269|PubMed:8706663}.		carbohydrate metabolic process [GO:0005975]; cellular response to heat [GO:0034605]; epithelial cell proliferation [GO:0050673]; glycosphingolipid biosynthetic process [GO:0006688]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; positive regulation of epithelial cell proliferation [GO:0050679]; protein glycosylation [GO:0006486]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialyltransferase activity [GO:0008373]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialyltransferase activity [GO:0008373]; carbohydrate metabolic process [GO:0005975]; cellular response to heat [GO:0034605]; epithelial cell proliferation [GO:0050673]; glycosphingolipid biosynthetic process [GO:0006688]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; positive regulation of epithelial cell proliferation [GO:0050679]; protein glycosylation [GO:0006486]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q92186	reviewed	SIA8B_HUMAN	Alpha-2,8-sialyltransferase 8B (EC 2.4.99.-) (Sialyltransferase 8B) (SIAT8-B) (Sialyltransferase St8Sia II) (ST8SiaII) (Sialyltransferase X) (STX)	ST8SIA2 SIAT8B STX	Homo sapiens (Human)	375	FUNCTION: May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.		carbohydrate metabolic process [GO:0005975]; ganglioside biosynthetic process [GO:0001574]; N-glycan processing [GO:0006491]; nervous system development [GO:0007399]; neuron projection extension [GO:1990138]; oligosaccharide metabolic process [GO:0009311]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of synapse assembly [GO:0051965]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]; response to cocaine [GO:0042220]	early endosome [GO:0005769]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialic acid binding [GO:0033691]	early endosome [GO:0005769]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialic acid binding [GO:0033691]; carbohydrate metabolic process [GO:0005975]; ganglioside biosynthetic process [GO:0001574]; N-glycan processing [GO:0006491]; nervous system development [GO:0007399]; neuron projection extension [GO:1990138]; oligosaccharide metabolic process [GO:0009311]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of synapse assembly [GO:0051965]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]; response to cocaine [GO:0042220]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q92187	reviewed	SIA8D_HUMAN	CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.99.-) (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase-1) (Sialyltransferase 8D) (SIAT8-D) (Sialyltransferase St8Sia IV) (ST8SiaIV)	ST8SIA4 PST PST1 SIAT8D	Homo sapiens (Human)	359	FUNCTION: Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.		ganglioside biosynthetic process [GO:0001574]; N-glycan processing [GO:0006491]; nervous system development [GO:0007399]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]	Golgi membrane [GO:0000139]	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialic acid binding [GO:0033691]	Golgi membrane [GO:0000139]; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialic acid binding [GO:0033691]; ganglioside biosynthetic process [GO:0001574]; N-glycan processing [GO:0006491]; nervous system development [GO:0007399]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q92466	reviewed	DDB2_HUMAN	DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2)	DDB2	Homo sapiens (Human)	427	FUNCTION: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:9892649, PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:32789493). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:16260596, PubMed:12944386, PubMed:14751237, PubMed:32789493). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:16260596, PubMed:12944386). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:26572825). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16678110, PubMed:16473935). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16678110, PubMed:16473935). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR (PubMed:26572825). {ECO:0000269|PubMed:10882109, ECO:0000269|PubMed:11278856, ECO:0000269|PubMed:11705987, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:12944386, ECO:0000269|PubMed:14751237, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:26572825, ECO:0000269|PubMed:32789493, ECO:0000269|PubMed:9892649}.; FUNCTION: [Isoform D1]: Inhibits UV-damaged DNA repair. {ECO:0000269|PubMed:14751237}.; FUNCTION: [Isoform D2]: Inhibits UV-damaged DNA repair. {ECO:0000269|PubMed:14751237}.		cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; pyrimidine dimer repair [GO:0006290]; response to UV [GO:0009411]; UV-damage excision repair [GO:0070914]	cell junction [GO:0030054]; chromatin [GO:0000785]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734]	damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; protein-containing complex binding [GO:0044877]	cell junction [GO:0030054]; chromatin [GO:0000785]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; protein-containing complex binding [GO:0044877]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; pyrimidine dimer repair [GO:0006290]; response to UV [GO:0009411]; UV-damage excision repair [GO:0070914]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10777490, ECO:0000269|PubMed:10777491, ECO:0000269|PubMed:11705987, ECO:0000269|PubMed:12944386, ECO:0000269|PubMed:14751237, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16713579, ECO:0000269|PubMed:17635991, ECO:0000269|PubMed:18593899}. Chromosome {ECO:0000269|PubMed:32789493}. Note=Accumulates at sites of DNA damage following UV irradiation. {ECO:0000269|PubMed:32789493}.
Q92481	reviewed	AP2B_HUMAN	Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta)	TFAP2B	Homo sapiens (Human)	460	FUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}.		anatomical structure development [GO:0048856]; aorta morphogenesis [GO:0035909]; collecting duct development [GO:0072044]; distal tubule development [GO:0072017]; ductus arteriosus closure [GO:0097070]; fat cell differentiation [GO:0045444]; forelimb morphogenesis [GO:0035136]; glucose metabolic process [GO:0006006]; hindlimb morphogenesis [GO:0035137]; kidney development [GO:0001822]; metanephric nephron development [GO:0072210]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of BMP signaling pathway [GO:0030510]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; retina layer formation [GO:0010842]; skin development [GO:0043588]; smooth muscle tissue development [GO:0048745]; sympathetic nervous system development [GO:0048485]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure development [GO:0048856]; aorta morphogenesis [GO:0035909]; collecting duct development [GO:0072044]; distal tubule development [GO:0072017]; ductus arteriosus closure [GO:0097070]; fat cell differentiation [GO:0045444]; forelimb morphogenesis [GO:0035136]; glucose metabolic process [GO:0006006]; hindlimb morphogenesis [GO:0035137]; kidney development [GO:0001822]; metanephric nephron development [GO:0072210]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of BMP signaling pathway [GO:0030510]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; retina layer formation [GO:0010842]; skin development [GO:0043588]; smooth muscle tissue development [GO:0048745]; sympathetic nervous system development [GO:0048485]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61313}. Note=In the brain, localizes to the arcuate hypothalamic nucleus, the ventromedial hypothalamic nucleus and the accumbens nucleus of the ventral striatum. {ECO:0000250|UniProtKB:Q61313}.
Q92482	reviewed	AQP3_HUMAN	Aquaporin-3 (AQP-3) (Aquaglyceroporin-3)	AQP3	Homo sapiens (Human)	292	FUNCTION: Water channel required to promote glycerol permeability and water transport across cell membranes (PubMed:12239222, PubMed:30420639). Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity). {ECO:0000250|UniProtKB:Q8R2N1, ECO:0000269|PubMed:12239222, ECO:0000269|PubMed:30420639}.	MISCELLANEOUS: [Isoform 2]: Due to a polymorphism at the 5'-splice donor site of intron 5, leading to exon 5 skipping and premature termination of translation. This is the molecular basis of the GIL blood group. {ECO:0000305}.	cellular response to hypoxia [GO:0071456]; cellular response to oxygen-glucose deprivation [GO:0090650]; establishment of localization in cell [GO:0051649]; glycerol transmembrane transport [GO:0015793]; odontogenesis [GO:0042476]; positive regulation of immune system process [GO:0002684]; regulation of keratinocyte differentiation [GO:0045616]; renal water absorption [GO:0070295]; renal water homeostasis [GO:0003091]; response to calcium ion [GO:0051592]; response to retinoic acid [GO:0032526]; response to vitamin D [GO:0033280]; water transport [GO:0006833]	basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	glycerol channel activity [GO:0015254]; identical protein binding [GO:0042802]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250]	basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; glycerol channel activity [GO:0015254]; identical protein binding [GO:0042802]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250]; cellular response to hypoxia [GO:0071456]; cellular response to oxygen-glucose deprivation [GO:0090650]; establishment of localization in cell [GO:0051649]; glycerol transmembrane transport [GO:0015793]; odontogenesis [GO:0042476]; positive regulation of immune system process [GO:0002684]; regulation of keratinocyte differentiation [GO:0045616]; renal water absorption [GO:0070295]; renal water homeostasis [GO:0003091]; response to calcium ion [GO:0051592]; response to retinoic acid [GO:0032526]; response to vitamin D [GO:0033280]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12239222}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47862}. Basolateral cell membrane {ECO:0000250|UniProtKB:P47862}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47862}.
Q92484	reviewed	ASM3A_HUMAN	Acid sphingomyelinase-like phosphodiesterase 3a (ASM-like phosphodiesterase 3a) (EC 3.1.4.-)	SMPDL3A ASML3A	Homo sapiens (Human)	453	FUNCTION: Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:25288789, PubMed:26783088). Has in vitro activity with p-nitrophenyl-TMP (PubMed:25288789). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (PubMed:25288789, PubMed:26783088). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine (PubMed:26783088). Does not have sphingomyelin phosphodiesterase activity (PubMed:25288789, PubMed:26783088). {ECO:0000269|PubMed:25288789, ECO:0000269|PubMed:26783088}.		nucleoside triphosphate catabolic process [GO:0009143]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	phosphoric diester hydrolase activity [GO:0008081]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; phosphoric diester hydrolase activity [GO:0008081]; zinc ion binding [GO:0008270]; nucleoside triphosphate catabolic process [GO:0009143]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25288789}.
Q92485	reviewed	ASM3B_HUMAN	Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-)	SMPDL3B ASML3B ASMLPD	Homo sapiens (Human)	455	FUNCTION: Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity). {ECO:0000250|UniProtKB:P58242, ECO:0000269|PubMed:26095358}.		inflammatory response [GO:0006954]; innate immune response [GO:0045087]; membrane lipid catabolic process [GO:0046466]; negative regulation of inflammatory response [GO:0050728]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; sphingomyelin catabolic process [GO:0006685]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	hydrolase activity, acting on glycosyl bonds [GO:0016798]; phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767]; zinc ion binding [GO:0008270]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; membrane lipid catabolic process [GO:0046466]; negative regulation of inflammatory response [GO:0050728]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; sphingomyelin catabolic process [GO:0006685]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P58242}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P58242}.
Q92496	reviewed	FHR4_HUMAN	Complement factor H-related protein 4 (FHR-4)	CFHR4 CFHL4 FHR4	Homo sapiens (Human)	578	FUNCTION: Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.		complement activation [GO:0006956]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	complement component C3b binding [GO:0001851]; lipid transporter activity [GO:0005319]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; complement component C3b binding [GO:0001851]; lipid transporter activity [GO:0005319]; complement activation [GO:0006956]	SUBCELLULAR LOCATION: Secreted.
Q92499	reviewed	DDX1_HUMAN	ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB)	DDX1	Homo sapiens (Human)	740	FUNCTION: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}.		defense response to virus [GO:0051607]; DNA duplex unwinding [GO:0032508]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of translational initiation [GO:0006446]; response to exogenous dsRNA [GO:0043330]; spliceosomal complex assembly [GO:0000245]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	cleavage body [GO:0071920]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; tRNA-splicing ligase complex [GO:0072669]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA/RNA helicase activity [GO:0033677]; double-stranded RNA binding [GO:0003725]; exonuclease activity [GO:0004527]; nuclease activity [GO:0004518]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coregulator activity [GO:0003712]	cleavage body [GO:0071920]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; tRNA-splicing ligase complex [GO:0072669]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA/RNA helicase activity [GO:0033677]; double-stranded RNA binding [GO:0003725]; exonuclease activity [GO:0004527]; nuclease activity [GO:0004518]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coregulator activity [GO:0003712]; defense response to virus [GO:0051607]; DNA duplex unwinding [GO:0032508]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of translational initiation [GO:0006446]; response to exogenous dsRNA [GO:0043330]; spliceosomal complex assembly [GO:0000245]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91VR5}. Mitochondrion {ECO:0000250|UniProtKB:Q91VR5}. Note=Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR-induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM-dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction. Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). Colocalizes in the cytosol with DDX21, DHX36 and TICAM1. Colocalizes in the mitochondria with TICAM1 and poly(I:C) RNA ligand. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) stimulation (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:24608264}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20573827}. Note=(Microbial infection) Relocalized to the cytoplasm with a perinuclear staining pattern in avian infectious bronchitis virus (IBV)-infected cells (PubMed:20573827). Required for proper localization of HIV-1 Rev (PubMed:15567440). {ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:20573827}.
Q92502	reviewed	STAR8_HUMAN	StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3)	STARD8 DLC3 KIAA0189	Homo sapiens (Human)	1023	FUNCTION: Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. {ECO:0000269|PubMed:17976533}.		actin cytoskeleton organization [GO:0030036]; regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165]	focal adhesion [GO:0005925]	GTPase activator activity [GO:0005096]; lipid binding [GO:0008289]	focal adhesion [GO:0005925]; GTPase activator activity [GO:0005096]; lipid binding [GO:0008289]; actin cytoskeleton organization [GO:0030036]; regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:17976533}.
Q92503	reviewed	S14L1_HUMAN	SEC14-like protein 1	SEC14L1 SEC14L	Homo sapiens (Human)	715	FUNCTION: May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of RIGI, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of RIGI with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608). {ECO:0000269|PubMed:17092608, ECO:0000269|PubMed:23843640}.		choline transport [GO:0015871]; innate immune response [GO:0045087]; negative regulation of RIG-I signaling pathway [GO:0039536]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	protein sequestering activity [GO:0140311]; RIG-I binding [GO:0039552]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; protein sequestering activity [GO:0140311]; RIG-I binding [GO:0039552]; choline transport [GO:0015871]; innate immune response [GO:0045087]; negative regulation of RIG-I signaling pathway [GO:0039536]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17092608, ECO:0000269|PubMed:23843640}. Golgi apparatus {ECO:0000269|PubMed:17092608}.
Q92504	reviewed	S39A7_HUMAN	Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Really interesting new gene 5 protein) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7)	SLC39A7 HKE4 RING5	Homo sapiens (Human)	469	FUNCTION: Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:14525538, PubMed:15705588, PubMed:29980658, PubMed:28205653). Acts as gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation (PubMed:29980658, PubMed:22317921, PubMed:28205653). Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function (By similarity). Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts (PubMed:29980658, PubMed:30237509). Mediates Zn(2+)-induced ferroptosis (PubMed:33608508). {ECO:0000250|UniProtKB:Q31125, ECO:0000269|PubMed:14525538, ECO:0000269|PubMed:15705588, ECO:0000269|PubMed:22317921, ECO:0000269|PubMed:28205653, ECO:0000269|PubMed:29980658, ECO:0000269|PubMed:30237509, ECO:0000269|PubMed:30718914, ECO:0000269|PubMed:33608508}.		B cell differentiation [GO:0030183]; intracellular zinc ion homeostasis [GO:0006882]; regulation of ferroptosis [GO:0110075]; skin epidermis development [GO:0098773]; zinc ion transmembrane transport [GO:0071577]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	zinc ion transmembrane transporter activity [GO:0005385]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; zinc ion transmembrane transporter activity [GO:0005385]; B cell differentiation [GO:0030183]; intracellular zinc ion homeostasis [GO:0006882]; regulation of ferroptosis [GO:0110075]; skin epidermis development [GO:0098773]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14525538, ECO:0000269|PubMed:29980658, ECO:0000269|PubMed:30237509, ECO:0000269|PubMed:30718914}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:15705588}; Multi-pass membrane protein {ECO:0000255}.
Q92506	reviewed	DHB8_HUMAN	(3R)-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (HSD17B8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (Estradiol 17-beta-dehydrogenase 8) (EC 1.1.1.62) (Protein Ke6) (Ke6) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)	HSD17B8 FABGL HKE6 RING2 SDR30C1	Homo sapiens (Human)	261	FUNCTION: Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex that acts as a scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function (PubMed:19571038, PubMed:25203508, PubMed:30508570). Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+) (PubMed:19571038). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters (Probable) (PubMed:30508570). NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol (PubMed:17978863). {ECO:0000269|PubMed:17978863, ECO:0000269|PubMed:19571038, ECO:0000269|PubMed:25203508, ECO:0000303|PubMed:30508570, ECO:0000305|PubMed:25203508}.	MISCELLANEOUS: The fatty acyl-CoA dehydrogenase activity is several thousand times higher than the estradiol and testosterone 17beta-hydroxysteroid dehydrogenase conversion. {ECO:0000269|PubMed:19571038}.	androgen metabolic process [GO:0008209]; estrogen biosynthetic process [GO:0006703]; fatty acid biosynthetic process [GO:0006633]; protein heterotetramerization [GO:0051290]	mitochondrial envelope [GO:0005740]; mitochondrial matrix [GO:0005759]; oxidoreductase complex [GO:1990204]; plasma membrane [GO:0005886]	(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity [GO:0106386]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; NADH binding [GO:0070404]; testosterone dehydrogenase (NAD+) activity [GO:0047035]	mitochondrial envelope [GO:0005740]; mitochondrial matrix [GO:0005759]; oxidoreductase complex [GO:1990204]; plasma membrane [GO:0005886]; (3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity [GO:0106386]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; NADH binding [GO:0070404]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; androgen metabolic process [GO:0008209]; estrogen biosynthetic process [GO:0006703]; fatty acid biosynthetic process [GO:0006633]; protein heterotetramerization [GO:0051290]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:19571038}.
Q92508	reviewed	PIEZ1_HUMAN	Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A)	PIEZO1 FAM38A KIAA0233	Homo sapiens (Human)	2521	FUNCTION: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation. {ECO:0000250|UniProtKB:E2JF22, ECO:0000269|PubMed:20016066, ECO:0000269|PubMed:23479567, ECO:0000269|PubMed:23695678, ECO:0000269|PubMed:25119035, ECO:0000269|PubMed:29799007}.	MISCELLANEOUS: Piezo comes from the Greek 'piesi' meaning pressure.	cellular response to mechanical stimulus [GO:0071260]; detection of mechanical stimulus [GO:0050982]; monoatomic cation transport [GO:0006812]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of integrin activation [GO:0033625]; positive regulation of myotube differentiation [GO:0010831]; regulation of membrane potential [GO:0042391]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]	mechanosensitive monoatomic ion channel activity [GO:0008381]; monoatomic cation channel activity [GO:0005261]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; mechanosensitive monoatomic ion channel activity [GO:0008381]; monoatomic cation channel activity [GO:0005261]; cellular response to mechanical stimulus [GO:0071260]; detection of mechanical stimulus [GO:0050982]; monoatomic cation transport [GO:0006812]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of integrin activation [GO:0033625]; positive regulation of myotube differentiation [GO:0010831]; regulation of membrane potential [GO:0042391]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20016066}; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q0KL00}. Cell membrane {ECO:0000269|PubMed:22529292, ECO:0000269|PubMed:23479567}; Multi-pass membrane protein {ECO:0000305}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:25119035}. Cell membrane {ECO:0000250|UniProtKB:E2JF22}; Multi-pass membrane protein. Note=In erythrocytes, located in the plasma membrane (PubMed:22529292, PubMed:23479567). Accumulates at the leading apical lamellipodia of endothelial cells in response to shear stress (PubMed:25119035). Colocalizes with F-actin and MYH9 at the actomyosin cortex in myoblasts. {ECO:0000250|UniProtKB:E2JF22, ECO:0000269|PubMed:22529292, ECO:0000269|PubMed:23479567, ECO:0000269|PubMed:25119035}.
Q92519	reviewed	TRIB2_HUMAN	Tribbles homolog 2 (TRB-2)	TRIB2 TRB2	Homo sapiens (Human)	343	FUNCTION: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). {ECO:0000250|UniProtKB:Q28283, ECO:0000250|UniProtKB:Q96RU8}.	MISCELLANEOUS: Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.	negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of MAP kinase activity [GO:0043405]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]	mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase inhibitor activity [GO:0004860]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase inhibitor activity [GO:0004860]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of MAP kinase activity [GO:0043405]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=May associate with the cytoskeleton. {ECO:0000250}.
Q92520	reviewed	FAM3C_HUMAN	Protein FAM3C (Interleukin-like EMT inducer)	FAM3C ILEI GS3786	Homo sapiens (Human)	227	FUNCTION: May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.	MISCELLANEOUS: Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly correlated with metastasis formation and survival.		extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; platelet dense granule lumen [GO:0031089]	cytokine activity [GO:0005125]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; platelet dense granule lumen [GO:0031089]; cytokine activity [GO:0005125]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasmic vesicle {ECO:0000269|PubMed:16959614}. Note=Cytoplasmic in some cancer cells.
Q92521	reviewed	PIGB_HUMAN	GPI mannosyltransferase 3 (EC 2.4.1.-) (GPI mannosyltransferase III) (GPI-MT-III) (Phosphatidylinositol-glycan biosynthesis class B protein) (PIG-B)	PIGB	Homo sapiens (Human)	554	FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly. {ECO:0000269|PubMed:8861954}.		GPI anchor biosynthetic process [GO:0006506]; mannosylation [GO:0097502]; preassembly of GPI anchor in ER membrane [GO:0016254]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	alpha-1,2-mannosyltransferase activity [GO:0000026]; glycolipid mannosyltransferase activity [GO:0004376]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; alpha-1,2-mannosyltransferase activity [GO:0000026]; glycolipid mannosyltransferase activity [GO:0004376]; mannosyltransferase activity [GO:0000030]; GPI anchor biosynthetic process [GO:0006506]; mannosylation [GO:0097502]; preassembly of GPI anchor in ER membrane [GO:0016254]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8861954}; Multi-pass membrane protein {ECO:0000269|PubMed:8861954}.
Q92522	reviewed	H1X_HUMAN	Histone H1.10 (Histone H1x)	H1-10 H1FX	Homo sapiens (Human)	213	FUNCTION: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.		chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	cadherin binding [GO:0045296]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527]; chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q92523	reviewed	CPT1B_HUMAN	Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1-M) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (CPT I) (CPTI-M) (Carnitine palmitoyltransferase 1B) (Carnitine palmitoyltransferase I-like protein)	CPT1B KIAA1670	Homo sapiens (Human)	772		MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the CHKB protein from a non-overlapping reading frame.	carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid transport [GO:0015909]; response to blue light [GO:0009637]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	carnitine O-palmitoyltransferase activity [GO:0004095]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; carnitine O-palmitoyltransferase activity [GO:0004095]; carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid transport [GO:0015909]; response to blue light [GO:0009637]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000305|PubMed:9344464}; Multi-pass membrane protein {ECO:0000255}.
Q92526	reviewed	TCPW_HUMAN	T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (CCT-zeta-like) (TCP-1-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303)	CCT6B	Homo sapiens (Human)	530	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. {ECO:0000305|PubMed:8812458}.		protein folding [GO:0006457]	chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]	chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:8812458}.
Q92529	reviewed	SHC3_HUMAN	SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)	SHC3 NSHC SHCC	Homo sapiens (Human)	594	FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.		central nervous system development [GO:0007417]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular signal transduction [GO:0035556]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; central nervous system development [GO:0007417]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular signal transduction [GO:0035556]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	
Q92530	reviewed	PSMF1_HUMAN	Proteasome inhibitor PI31 subunit (hPI31)	PSMF1	Homo sapiens (Human)	271	FUNCTION: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. {ECO:0000269|PubMed:10764772}.		negative regulation of proteasomal protein catabolic process [GO:1901799]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; proteasome core complex [GO:0005839]	endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; proteasome core complex [GO:0005839]; endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; negative regulation of proteasomal protein catabolic process [GO:1901799]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18495667}. Endoplasmic reticulum {ECO:0000269|PubMed:18495667}.
Q92535	reviewed	PIGC_HUMAN	Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (Phosphatidylinositol-glycan biosynthesis class C protein) (PIG-C)	PIGC GPI2	Homo sapiens (Human)	297	FUNCTION: Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. {ECO:0000269|PubMed:16162815, ECO:0000269|PubMed:27694521, ECO:0000269|PubMed:8806613}.		GPI anchor biosynthetic process [GO:0006506]	endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]	catalytic activity [GO:0003824]	endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; catalytic activity [GO:0003824]; GPI anchor biosynthetic process [GO:0006506]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8806613}; Multi-pass membrane protein {ECO:0000305}.
Q92536	reviewed	YLAT2_HUMAN	Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)	SLC7A6 KIAA0245	Homo sapiens (Human)	515	FUNCTION: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:9829974, PubMed:10903140, PubMed:16785209, PubMed:31705628, PubMed:15756301, PubMed:11311135, PubMed:17329401, PubMed:14603368, PubMed:19562367). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). {ECO:0000250|UniProtKB:D3ZMM8, ECO:0000250|UniProtKB:Q8BGK6, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:19562367, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974}.		amino acid transmembrane transport [GO:0003333]; glycine betaine transport [GO:0031460]; L-arginine transmembrane transport [GO:1903826]; leucine transport [GO:0015820]; neutral amino acid transport [GO:0015804]; nitric oxide biosynthetic process [GO:0006809]; ornithine transport [GO:0015822]	plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; arginine binding [GO:0034618]; basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine:L-arginine antiporter activity [GO:0106439]	plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; arginine binding [GO:0034618]; basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine:L-arginine antiporter activity [GO:0106439]; amino acid transmembrane transport [GO:0003333]; glycine betaine transport [GO:0031460]; L-arginine transmembrane transport [GO:1903826]; leucine transport [GO:0015820]; neutral amino acid transport [GO:0015804]; nitric oxide biosynthetic process [GO:0006809]; ornithine transport [GO:0015822]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16785209}; Multi-pass membrane protein {ECO:0000255}.
Q92537	reviewed	SUSD6_HUMAN	Sushi domain-containing protein 6 (Drug-activated gene overexpressed protein)	SUSD6 DRAGO KIAA0247	Homo sapiens (Human)	303	FUNCTION: May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity). {ECO:0000250|UniProtKB:Q8BGE4, ECO:0000269|PubMed:20236627, ECO:0000269|PubMed:24652652}.		DNA damage response [GO:0006974]	membrane [GO:0016020]		membrane [GO:0016020]; DNA damage response [GO:0006974]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q92538	reviewed	GBF1_HUMAN	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1)	GBF1 KIAA0248	Homo sapiens (Human)	1859	FUNCTION: Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:12047556, PubMed:12808027, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adapter protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891). Plays a role in maintaining mitochondrial morphology (PubMed:25190516). {ECO:0000250|UniProtKB:Q9R1D7, ECO:0000269|PubMed:12047556, ECO:0000269|PubMed:12808027, ECO:0000269|PubMed:15616190, ECO:0000269|PubMed:16926190, ECO:0000269|PubMed:17666033, ECO:0000269|PubMed:17956946, ECO:0000269|PubMed:18003980, ECO:0000269|PubMed:18063581, ECO:0000269|PubMed:19461073, ECO:0000269|PubMed:22185782, ECO:0000269|PubMed:22573891, ECO:0000269|PubMed:23386609, ECO:0000269|PubMed:23418352, ECO:0000269|PubMed:24213530, ECO:0000269|PubMed:25190516, ECO:0000305|PubMed:19039328, ECO:0000305|PubMed:22573891}.		cell activation involved in immune response [GO:0002263]; cellular response to virus [GO:0098586]; cilium assembly [GO:0060271]; COPI coating of Golgi vesicle [GO:0048205]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; establishment of monopolar cell polarity [GO:0061162]; Golgi disassembly [GO:0090166]; Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; neutrophil chemotaxis [GO:0030593]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to endoplasmic reticulum tubular network [GO:1903420]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of ARF protein signal transduction [GO:0032012]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization to cell surface [GO:2000008]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cell leading edge [GO:0031252]; cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]	cell leading edge [GO:0031252]; cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; cell activation involved in immune response [GO:0002263]; cellular response to virus [GO:0098586]; cilium assembly [GO:0060271]; COPI coating of Golgi vesicle [GO:0048205]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; establishment of monopolar cell polarity [GO:0061162]; Golgi disassembly [GO:0090166]; Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; neutrophil chemotaxis [GO:0030593]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to endoplasmic reticulum tubular network [GO:1903420]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of ARF protein signal transduction [GO:0032012]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization to cell surface [GO:2000008]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:12047556, ECO:0000269|PubMed:12808027, ECO:0000269|PubMed:15616190}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:12808027}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23386609}. Golgi apparatus {ECO:0000269|PubMed:31519766}. Cytoplasm {ECO:0000269|PubMed:22573891, ECO:0000269|PubMed:31519766}. Lipid droplet {ECO:0000269|PubMed:21789191}. Membrane; Peripheral membrane protein {ECO:0000305}. Note=Cycles rapidly on and off early Golgi membranes (PubMed:15616190). Stabilized on membranes when complexed with ARF1-GDP and is released from both ARF1 and membranes after it catalyzes GDP displacement and ARF1 binds GTP. Continuous cycles of recruitment and dissociation of GBF1 to membranes are required for sustained ARF activation and COP I recruitment (PubMed:15813748). In neutrophils is translocated from the Golgi to the leading edge upon GPCR stimulation (PubMed:22573891). Localization to lipid droplets is questionable (PubMed:22185782). {ECO:0000269|PubMed:15616190, ECO:0000269|PubMed:22185782, ECO:0000269|PubMed:22573891, ECO:0000305|PubMed:15616190, ECO:0000305|PubMed:15813748}.
Q92539	reviewed	LPIN2_HUMAN	Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2)	LPIN2 KIAA0249	Homo sapiens (Human)	896	FUNCTION: Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}.		cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; lipid metabolic process [GO:0006629]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713]; cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; lipid metabolic process [GO:0006629]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Translocates to endoplasmic reticulum membrane with increasing levels of oleate. {ECO:0000250}.
Q92540	reviewed	SMG7_HUMAN	Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7)	SMG7 C1orf16 EST1C KIAA0250	Homo sapiens (Human)	1137	FUNCTION: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}.		mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]	protein phosphatase 2A binding [GO:0051721]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]; protein phosphatase 2A binding [GO:0051721]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14636577}. Nucleus {ECO:0000269|PubMed:14636577}. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. {ECO:0000269|PubMed:14636577}.
Q92541	reviewed	RTF1_HUMAN	RNA polymerase-associated protein RTF1 homolog	RTF1 KIAA0252	Homo sapiens (Human)	710	FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}.		blastocyst growth [GO:0001832]; endodermal cell fate commitment [GO:0001711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055]	Cdc73/Paf1 complex [GO:0016593]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]	Cdc73/Paf1 complex [GO:0016593]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; blastocyst growth [GO:0001832]; endodermal cell fate commitment [GO:0001711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}.
Q92542	reviewed	NICA_HUMAN	Nicastrin	NCSTN KIAA0253 UNQ1874/PRO4317	Homo sapiens (Human)	709	FUNCTION: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. {ECO:0000269|PubMed:10993067, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}.		adult behavior [GO:0030534]; amyloid precursor protein biosynthetic process [GO:0042983]; amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; cellular response to calcium ion [GO:0071277]; central nervous system myelination [GO:0022010]; cerebellum development [GO:0021549]; dopamine receptor signaling pathway [GO:0007212]; epithelial cell proliferation [GO:0050673]; glutamate receptor signaling pathway [GO:0007215]; learning or memory [GO:0007611]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; myeloid cell homeostasis [GO:0002262]; neuron apoptotic process [GO:0051402]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of long-term synaptic potentiation [GO:1900271]; short-term synaptic potentiation [GO:1990926]; T cell proliferation [GO:0042098]	azurophil granule membrane [GO:0035577]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; sarcolemma [GO:0042383]; synaptic vesicle [GO:0008021]	aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; ATPase binding [GO:0051117]; growth factor receptor binding [GO:0070851]; protein-macromolecule adaptor activity [GO:0030674]	azurophil granule membrane [GO:0035577]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; sarcolemma [GO:0042383]; synaptic vesicle [GO:0008021]; aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; ATPase binding [GO:0051117]; growth factor receptor binding [GO:0070851]; protein-macromolecule adaptor activity [GO:0030674]; adult behavior [GO:0030534]; amyloid precursor protein biosynthetic process [GO:0042983]; amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; cellular response to calcium ion [GO:0071277]; central nervous system myelination [GO:0022010]; cerebellum development [GO:0021549]; dopamine receptor signaling pathway [GO:0007212]; epithelial cell proliferation [GO:0050673]; glutamate receptor signaling pathway [GO:0007215]; learning or memory [GO:0007611]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; myeloid cell homeostasis [GO:0002262]; neuron apoptotic process [GO:0051402]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of long-term synaptic potentiation [GO:1900271]; short-term synaptic potentiation [GO:1990926]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10993067, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:26776682}; Single-pass type I membrane protein {ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10993067}; Single-pass type I membrane protein {ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Q92543	reviewed	SNX19_HUMAN	Sorting nexin-19	SNX19 KIAA0254	Homo sapiens (Human)	992	FUNCTION: Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). {ECO:0000250|UniProtKB:Q6P4T1, ECO:0000269|PubMed:24843546}.		chondrocyte differentiation [GO:0002062]; dense core granule maturation [GO:1990502]; establishment of localization in cell [GO:0051649]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]	cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]	phosphatidylinositol binding [GO:0035091]	cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; phosphatidylinositol binding [GO:0035091]; chondrocyte differentiation [GO:0002062]; dense core granule maturation [GO:1990502]; establishment of localization in cell [GO:0051649]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:Q6P4T1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6P4T1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6P4T1}. Cytoplasmic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q92544	reviewed	TM9S4_HUMAN	Transmembrane 9 superfamily member 4 (Tumor cannibalism associated protein 1)	TM9SF4 KIAA0255 TUCAP1	Homo sapiens (Human)	642	FUNCTION: Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578). {ECO:0000269|PubMed:19893578, ECO:0000269|PubMed:25659576, ECO:0000269|PubMed:25999474}.		cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to membrane [GO:0072657]; regulation of intracellular pH [GO:0051453]; response to hypoxia [GO:0001666]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]		early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to membrane [GO:0072657]; regulation of intracellular pH [GO:0051453]; response to hypoxia [GO:0001666]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:25999474}. Early endosome {ECO:0000269|PubMed:19893578}.
Q92546	reviewed	RGP1_HUMAN	RAB6A-GEF complex partner protein 2 (Retrograde Golgi transport protein RGP1 homolog)	RGP1 KIAA0258	Homo sapiens (Human)	391	FUNCTION: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. {ECO:0000269|PubMed:23091056}.		negative regulation of protein catabolic process [GO:0042177]; positive regulation of GTPase activity [GO:0043547]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Ric1-Rgp1 guanyl-nucleotide exchange factor complex [GO:0034066]; trans-Golgi network membrane [GO:0032588]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Ric1-Rgp1 guanyl-nucleotide exchange factor complex [GO:0034066]; trans-Golgi network membrane [GO:0032588]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of GTPase activity [GO:0043547]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23091056}. Membrane {ECO:0000269|PubMed:23091056}.
Q92547	reviewed	TOPB1_HUMAN	DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)	TOPBP1 KIAA0259	Homo sapiens (Human)	1522	FUNCTION: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control (PubMed:33592542). Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042). {ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:33592542}.		DNA damage response [GO:0006974]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; DNA replication initiation [GO:0006270]; homologous recombination [GO:0035825]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; response to ionizing radiation [GO:0010212]	actin cytoskeleton [GO:0015629]; BRCA1-B complex [GO:0070532]; chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; microtubule organizing center [GO:0005815]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; spindle pole [GO:0000922]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]	actin cytoskeleton [GO:0015629]; BRCA1-B complex [GO:0070532]; chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; microtubule organizing center [GO:0005815]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; spindle pole [GO:0000922]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; DNA damage response [GO:0006974]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; DNA replication initiation [GO:0006270]; homologous recombination [GO:0035825]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner. {ECO:0000250}.
Q92551	reviewed	IP6K1_HUMAN	Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1)	IP6K1 IHPK1 KIAA0263	Homo sapiens (Human)	441	FUNCTION: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.		inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; negative regulation of cold-induced thermogenesis [GO:0120163]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; inositol 5-diphosphate pentakisphosphate 5-kinase activity [GO:0052836]; inositol diphosphate tetrakisphosphate kinase activity [GO:0052839]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 3-kinase activity [GO:0052724]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; inositol 5-diphosphate pentakisphosphate 5-kinase activity [GO:0052836]; inositol diphosphate tetrakisphosphate kinase activity [GO:0052839]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 3-kinase activity [GO:0052724]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; negative regulation of cold-induced thermogenesis [GO:0120163]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11502751}. Nucleus {ECO:0000269|PubMed:11502751}.
Q92552	reviewed	RT27_HUMAN	Small ribosomal subunit protein mS27 (28S ribosomal protein S27, mitochondrial) (MRP-S27) (S27mt) (Mitochondrial ribosomal protein S27)	MRPS27 KIAA0264	Homo sapiens (Human)	414	FUNCTION: RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715). Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain (PubMed:22841715). Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:28714366). {ECO:0000269|PubMed:22841715, ECO:0000269|PubMed:28714366}.		cell population proliferation [GO:0008283]; mitochondrial translation [GO:0032543]; positive regulation of mitochondrial translation [GO:0070131]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	mitochondrial ribosome binding [GO:0097177]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; mitochondrial ribosome binding [GO:0097177]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049]; cell population proliferation [GO:0008283]; mitochondrial translation [GO:0032543]; positive regulation of mitochondrial translation [GO:0070131]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28714366}. Mitochondrion {ECO:0000269|PubMed:22841715, ECO:0000269|PubMed:25838379}.
Q92556	reviewed	ELMO1_HUMAN	Engulfment and cell motility protein 1 (Protein ced-12 homolog)	ELMO1 KIAA0281	Homo sapiens (Human)	727	FUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:12134158}.		actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell motility [GO:0048870]; phagocytosis, engulfment [GO:0006911]; Rac protein signal transduction [GO:0016601]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; guanyl-nucleotide exchange factor complex [GO:0032045]; membrane [GO:0016020]; plasma membrane [GO:0005886]	SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; guanyl-nucleotide exchange factor complex [GO:0032045]; membrane [GO:0016020]; plasma membrane [GO:0005886]; SH3 domain binding [GO:0017124]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell motility [GO:0048870]; phagocytosis, engulfment [GO:0006911]; Rac protein signal transduction [GO:0016601]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
Q92558	reviewed	WASF1_HUMAN	Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1)	WASF1 KIAA0269 SCAR1 WAVE1	Homo sapiens (Human)	559	FUNCTION: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:29961568, ECO:0000269|PubMed:9889097}.		actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; dendrite extension [GO:0097484]; lamellipodium morphogenesis [GO:0072673]; mitochondrion morphogenesis [GO:0070584]; modification of postsynaptic actin cytoskeleton [GO:0098885]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; protein-containing complex assembly [GO:0065003]; Rac protein signal transduction [GO:0016601]; receptor-mediated endocytosis [GO:0006898]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mitochondrial outer membrane [GO:0005741]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; SCAR complex [GO:0031209]	actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mitochondrial outer membrane [GO:0005741]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; SCAR complex [GO:0031209]; actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; dendrite extension [GO:0097484]; lamellipodium morphogenesis [GO:0072673]; mitochondrion morphogenesis [GO:0070584]; modification of postsynaptic actin cytoskeleton [GO:0098885]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; protein-containing complex assembly [GO:0065003]; Rac protein signal transduction [GO:0016601]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9889097}. Synapse {ECO:0000250|UniProtKB:Q5BJU7}. Cell junction, focal adhesion {ECO:0000269|PubMed:18559503}. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097). Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503). In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (By similarity). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9889097}.
Q92560	reviewed	BAP1_HUMAN	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6)	BAP1 KIAA0272 hucep-6	Homo sapiens (Human)	729	FUNCTION: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor (PubMed:9528852). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:9528852}.		common myeloid progenitor cell proliferation [GO:0035726]; erythrocyte maturation [GO:0043249]; gene expression [GO:0010467]; hematopoietic stem cell homeostasis [GO:0061484]; in utero embryonic development [GO:0001701]; leukocyte proliferation [GO:0070661]; macrophage homeostasis [GO:0061519]; mitotic cell cycle [GO:0000278]; monoubiquitinated protein deubiquitination [GO:0035520]; myeloid cell apoptotic process [GO:0033028]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; neuron cellular homeostasis [GO:0070050]; neutrophil differentiation [GO:0030223]; nucleate erythrocyte differentiation [GO:0043363]; platelet morphogenesis [GO:0036344]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein modification process [GO:0036211]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of inflammatory response [GO:0050727]; response to inorganic substance [GO:0010035]; thrombocyte differentiation [GO:0002574]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PR-DUB complex [GO:0035517]	chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; cysteine-type deubiquitinase activity [GO:0004843]; histone H2A deubiquitinase activity [GO:0140950]; peptidase activity [GO:0008233]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PR-DUB complex [GO:0035517]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; cysteine-type deubiquitinase activity [GO:0004843]; histone H2A deubiquitinase activity [GO:0140950]; peptidase activity [GO:0008233]; common myeloid progenitor cell proliferation [GO:0035726]; erythrocyte maturation [GO:0043249]; gene expression [GO:0010467]; hematopoietic stem cell homeostasis [GO:0061484]; in utero embryonic development [GO:0001701]; leukocyte proliferation [GO:0070661]; macrophage homeostasis [GO:0061519]; mitotic cell cycle [GO:0000278]; monoubiquitinated protein deubiquitination [GO:0035520]; myeloid cell apoptotic process [GO:0033028]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; neuron cellular homeostasis [GO:0070050]; neutrophil differentiation [GO:0030223]; nucleate erythrocyte differentiation [GO:0043363]; platelet morphogenesis [GO:0036344]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein modification process [GO:0036211]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of inflammatory response [GO:0050727]; response to inorganic substance [GO:0010035]; thrombocyte differentiation [GO:0002574]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:24703950}. Nucleus {ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:24748658, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:9528852}. Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950). {ECO:0000269|PubMed:24703950}.
Q92562	reviewed	FIG4_HUMAN	Polyphosphoinositide phosphatase (EC 3.1.3.-) (EC 3.1.3.36) (EC 3.1.3.86) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3) (Serine-protein phosphatase FIG4) (EC 3.1.3.16)	FIG4 KIAA0274 SAC3	Homo sapiens (Human)	907	FUNCTION: Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:17556371, PubMed:33098764). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate (PubMed:33098764). Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production (PubMed:33098764). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro (PubMed:17556371). {ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:33098764}.		locomotory behavior [GO:0007626]; myelin assembly [GO:0032288]; negative regulation of myelination [GO:0031642]; neuron development [GO:0048666]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; pigmentation [GO:0043473]; vacuole organization [GO:0007033]	early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; protein serine/threonine phosphatase activity [GO:0004722]	early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; protein serine/threonine phosphatase activity [GO:0004722]; locomotory behavior [GO:0007626]; myelin assembly [GO:0032288]; negative regulation of myelination [GO:0031642]; neuron development [GO:0048666]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; pigmentation [GO:0043473]; vacuole organization [GO:0007033]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:17556371}. Note=Localization requires VAC14 and PIKFYVE. {ECO:0000269|PubMed:17556371}.
Q92563	reviewed	TICN2_HUMAN	Testican-2 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2)	SPOCK2 KIAA0275 TICN2 UNQ269/PRO306	Homo sapiens (Human)	424	FUNCTION: May participate in diverse steps of neurogenesis. Binds calcium.		cellular response to leukemia inhibitory factor [GO:1990830]; extracellular matrix organization [GO:0030198]; negative regulation of endopeptidase activity [GO:0010951]; positive regulation of cell motility [GO:2000147]; positive regulation of cell-substrate adhesion [GO:0010811]; regulation of cell differentiation [GO:0045595]; synapse assembly [GO:0007416]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; glycosaminoglycan binding [GO:0005539]; metalloendopeptidase inhibitor activity [GO:0008191]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; glycosaminoglycan binding [GO:0005539]; metalloendopeptidase inhibitor activity [GO:0008191]; cellular response to leukemia inhibitory factor [GO:1990830]; extracellular matrix organization [GO:0030198]; negative regulation of endopeptidase activity [GO:0010951]; positive regulation of cell motility [GO:2000147]; positive regulation of cell-substrate adhesion [GO:0010811]; regulation of cell differentiation [GO:0045595]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
Q92564	reviewed	DCNL4_HUMAN	DCN1-like protein 4 (DCNL4) (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4)	DCUN1D4 KIAA0276	Homo sapiens (Human)	292	FUNCTION: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). {ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:26906416}.		positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]	nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182]	nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182]; positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26906416}.
Q92565	reviewed	RPGF5_HUMAN	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac)	RAPGEF5 GFR KIAA0277 MRGEF	Homo sapiens (Human)	580	FUNCTION: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:10934204}.		nervous system development [GO:0007399]; Ras protein signal transduction [GO:0007265]; small GTPase mediated signal transduction [GO:0007264]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085]; nervous system development [GO:0007399]; Ras protein signal transduction [GO:0007265]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Nucleus.
Q92567	reviewed	F168A_HUMAN	Protein FAM168A (Tongue cancer chemotherapy resistance-associated protein 1)	FAM168A KIAA0280 TCRP1	Homo sapiens (Human)	244	FUNCTION: In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels. {ECO:0000269|PubMed:21334329, ECO:0000269|PubMed:21603883, ECO:0000269|PubMed:23251525, ECO:0000269|PubMed:25260657}.		positive regulation of base-excision repair [GO:1905053]			positive regulation of base-excision repair [GO:1905053]	
Q92569	reviewed	P55G_HUMAN	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)	PIK3R3	Homo sapiens (Human)	461	FUNCTION: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.		B cell differentiation [GO:0030183]; cell migration involved in sprouting angiogenesis [GO:0002042]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; negative regulation of anoikis [GO:2000811]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; T cell differentiation [GO:0030217]	cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; phosphotyrosine residue binding [GO:0001784]	cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; phosphotyrosine residue binding [GO:0001784]; B cell differentiation [GO:0030183]; cell migration involved in sprouting angiogenesis [GO:0002042]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; negative regulation of anoikis [GO:2000811]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; T cell differentiation [GO:0030217]	
Q92570	reviewed	NR4A3_HUMAN	Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1)	NR4A3 CHN CSMF MINOR NOR1 TEC	Homo sapiens (Human)	626	FUNCTION: Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). {ECO:0000250|UniProtKB:P51179, ECO:0000250|UniProtKB:Q9QZB6, ECO:0000269|PubMed:20558821, ECO:0000269|PubMed:24022864}.		animal organ regeneration [GO:0031100]; cellular respiration [GO:0045333]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; cellular response to leptin stimulus [GO:0044320]; common myeloid progenitor cell proliferation [GO:0035726]; energy homeostasis [GO:0097009]; fat cell differentiation [GO:0045444]; gastrulation [GO:0007369]; intracellular signal transduction [GO:0035556]; mast cell degranulation [GO:0043303]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of feeding behavior [GO:2000253]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway [GO:0038097]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of monocyte aggregation [GO:1900625]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; pyruvate oxidation [GO:0009444]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell proliferation [GO:0061469]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	cAMP response element binding [GO:0035497]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; cAMP response element binding [GO:0035497]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; animal organ regeneration [GO:0031100]; cellular respiration [GO:0045333]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; cellular response to leptin stimulus [GO:0044320]; common myeloid progenitor cell proliferation [GO:0035726]; energy homeostasis [GO:0097009]; fat cell differentiation [GO:0045444]; gastrulation [GO:0007369]; intracellular signal transduction [GO:0035556]; mast cell degranulation [GO:0043303]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of feeding behavior [GO:2000253]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway [GO:0038097]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of monocyte aggregation [GO:1900625]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; pyruvate oxidation [GO:0009444]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell proliferation [GO:0061469]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Q92572	reviewed	AP3S1_HUMAN	AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a)	AP3S1 CLAPS3	Homo sapiens (Human)	193	FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.		anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; Golgi to vacuole transport [GO:0006896]; insulin receptor signaling pathway [GO:0008286]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]	AP-3 adaptor complex [GO:0030123]; AP-type membrane coat adaptor complex [GO:0030119]; axon cytoplasm [GO:1904115]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; presynapse [GO:0098793]; transport vesicle [GO:0030133]		AP-3 adaptor complex [GO:0030123]; AP-type membrane coat adaptor complex [GO:0030119]; axon cytoplasm [GO:1904115]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; presynapse [GO:0098793]; transport vesicle [GO:0030133]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; Golgi to vacuole transport [GO:0006896]; insulin receptor signaling pathway [GO:0008286]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Q92574	reviewed	TSC1_HUMAN	Hamartin (Tuberous sclerosis 1 protein)	TSC1 KIAA0243 TSC	Homo sapiens (Human)	1164	FUNCTION: Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12906785, PubMed:12271141, PubMed:28215400, PubMed:15340059, PubMed:24529379). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:9242607}.		activation of GTPase activity [GO:0090630]; adaptive immune response [GO:0002250]; adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; cardiac muscle cell differentiation [GO:0055007]; cell projection organization [GO:0030030]; cell-matrix adhesion [GO:0007160]; cellular response to oxygen-glucose deprivation [GO:0090650]; cellular response to starvation [GO:0009267]; cerebral cortex development [GO:0021987]; glucose import [GO:0046323]; hippocampus development [GO:0021766]; kidney development [GO:0001822]; memory T cell differentiation [GO:0043379]; myelination [GO:0042552]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; positive regulation of focal adhesion assembly [GO:0051894]; potassium ion transport [GO:0006813]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of cell-matrix adhesion [GO:0001952]; regulation of phosphoprotein phosphatase activity [GO:0043666]; regulation of stress fiber assembly [GO:0051492]; regulation of translation [GO:0006417]; response to insulin [GO:0032868]; rRNA export from nucleus [GO:0006407]; synapse organization [GO:0050808]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; TSC1-TSC2 complex [GO:0033596]	ATPase inhibitor activity [GO:0042030]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; TSC1-TSC2 complex [GO:0033596]; ATPase inhibitor activity [GO:0042030]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087]; activation of GTPase activity [GO:0090630]; adaptive immune response [GO:0002250]; adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; cardiac muscle cell differentiation [GO:0055007]; cell projection organization [GO:0030030]; cell-matrix adhesion [GO:0007160]; cellular response to oxygen-glucose deprivation [GO:0090650]; cellular response to starvation [GO:0009267]; cerebral cortex development [GO:0021987]; glucose import [GO:0046323]; hippocampus development [GO:0021766]; kidney development [GO:0001822]; memory T cell differentiation [GO:0043379]; myelination [GO:0042552]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; positive regulation of focal adhesion assembly [GO:0051894]; potassium ion transport [GO:0006813]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of cell-matrix adhesion [GO:0001952]; regulation of phosphoprotein phosphatase activity [GO:0043666]; regulation of stress fiber assembly [GO:0051492]; regulation of translation [GO:0006417]; response to insulin [GO:0032868]; rRNA export from nucleus [GO:0006407]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:24529379}; Peripheral membrane protein {ECO:0000269|PubMed:9809973}. Cytoplasm, cytosol {ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:9809973}. Note=Recruited to lysosomal membranes in a RHEB-dependent process in absence of nutrients (PubMed:24529379). In response to nutrients, the complex dissociates from lysosomal membranes and relocalizes to the cytosol (PubMed:24529379). {ECO:0000269|PubMed:24529379}.
Q92575	reviewed	UBXN4_HUMAN	UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2)	UBXN4 KIAA0242 UBXD2 UBXDC1	Homo sapiens (Human)	508	FUNCTION: Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). {ECO:0000269|PubMed:16968747, ECO:0000269|PubMed:19822669}.		response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]		cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16968747}; Peripheral membrane protein {ECO:0000269|PubMed:16968747}. Nucleus envelope {ECO:0000269|PubMed:16968747}. Note=Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER. {ECO:0000269|PubMed:16968747}.
Q92581	reviewed	SL9A6_HUMAN	Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6)	SLC9A6 KIAA0267 NHE6	Homo sapiens (Human)	701	FUNCTION: Endosomal Na(+), K(+)/H(+) antiporter (PubMed:15522866, PubMed:31676550, PubMed:32277048, PubMed:28635961). Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed:15522866, PubMed:31676550, PubMed:32277048, PubMed:28635961). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (PubMed:20130086). Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A1L3P4, ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:20130086, ECO:0000269|PubMed:28635961, ECO:0000269|PubMed:31676550, ECO:0000269|PubMed:32277048}.		axon extension [GO:0048675]; dendrite extension [GO:0097484]; establishment of cell polarity [GO:0030010]; monoatomic ion transport [GO:0006811]; neuron projection morphogenesis [GO:0048812]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]	early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]	identical protein binding [GO:0042802]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; identical protein binding [GO:0042802]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; axon extension [GO:0048675]; dendrite extension [GO:0097484]; establishment of cell polarity [GO:0030010]; monoatomic ion transport [GO:0006811]; neuron projection morphogenesis [GO:0048812]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:11641397, ECO:0000269|PubMed:11940519}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:11940519, ECO:0000269|PubMed:18057008, ECO:0000269|PubMed:28635961, ECO:0000269|PubMed:30296617, ECO:0000269|PubMed:32277048}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:11940519, ECO:0000269|PubMed:28635961}; Multi-pass membrane protein. Late endosome membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:11940519, ECO:0000269|PubMed:28635961, ECO:0000269|PubMed:30296617}; Multi-pass membrane protein {ECO:0000255}. Note=Present predominantly in the recycling compartments including early and recycling endosomes, but undergoes plasma membrane localization during vesicular recycling, which is enhanced upon certain stimuli, such as hypoxia (PubMed:28635961, PubMed:11940519, PubMed:30296617). Has a major plasmalemmal distribution in a few specialized cells, such as in vestibular hair bundles and osteoblasts (By similarity). {ECO:0000250|UniProtKB:A1L3P4, ECO:0000269|PubMed:11940519, ECO:0000269|PubMed:28635961, ECO:0000269|PubMed:30296617}.
Q92583	reviewed	CCL17_HUMAN	C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine)	CCL17 SCYA17 TARC	Homo sapiens (Human)	94	FUNCTION: Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes (PubMed:8702936, PubMed:9169480). Acts by binding to CCR4 at T-cell surface (PubMed:9169480, PubMed:10540332). Mediates GM-CSF/CSF2-driven pain and inflammation (PubMed:27525438). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation (By similarity). Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity). {ECO:0000250|UniProtKB:Q9WUZ6, ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:27525438, ECO:0000269|PubMed:8702936, ECO:0000269|PubMed:9169480}.		cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; signaling receptor binding [GO:0005102]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27525438, ECO:0000269|PubMed:29871928, ECO:0000269|PubMed:8702936}.
Q92585	reviewed	MAML1_HUMAN	Mastermind-like protein 1 (Mam-1)	MAML1 KIAA0200	Homo sapiens (Human)	1016	FUNCTION: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}.		atrioventricular node cell development [GO:0060928]; atrioventricular node development [GO:0003162]; myoblast differentiation [GO:0045445]; Notch signaling pathway [GO:0007219]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; protein phosphorylation [GO:0006468]	MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	peptide antigen binding [GO:0042605]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]	MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peptide antigen binding [GO:0042605]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; atrioventricular node cell development [GO:0060928]; atrioventricular node development [GO:0003162]; myoblast differentiation [GO:0045445]; Notch signaling pathway [GO:0007219]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11101851}. Note=Nuclear, in a punctate manner.
Q92597	reviewed	NDRG1_HUMAN	Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42)	NDRG1 CAP43 DRG1 RTP	Homo sapiens (Human)	394	FUNCTION: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. {ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670, ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}.		cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; mast cell activation [GO:0045576]; negative regulation of cell population proliferation [GO:0008285]; peripheral nervous system myelin maintenance [GO:0032287]; response to metal ion [GO:0010038]; signal transduction [GO:0007165]	adherens junction [GO:0005912]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	cadherin binding [GO:0045296]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267]	adherens junction [GO:0005912]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; cadherin binding [GO:0045296]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267]; cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; mast cell activation [GO:0045576]; negative regulation of cell population proliferation [GO:0008285]; peripheral nervous system myelin maintenance [GO:0032287]; response to metal ion [GO:0010038]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane.
Q92598	reviewed	HS105_HUMAN	Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein)	HSPH1 HSP105 HSP110 KIAA0201	Homo sapiens (Human)	858	FUNCTION: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}.		chaperone cofactor-dependent protein refolding [GO:0051085]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of NK T cell activation [GO:0051135]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	adenyl-nucleotide exchange factor activity [GO:0000774]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; adenyl-nucleotide exchange factor activity [GO:0000774]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; chaperone cofactor-dependent protein refolding [GO:0051085]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of NK T cell activation [GO:0051135]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9931472}.
Q92599	reviewed	SEPT8_HUMAN	Septin-8	SEPTIN8 KIAA0202 SEPT8	Homo sapiens (Human)	483	FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. {ECO:0000269|PubMed:27084579}.	MISCELLANEOUS: [Isoform 2]: KIAA0202a differs from KIAA0202c at the level of the 3'-UTR. {ECO:0000305}.	cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of intracellular protein transport [GO:0033157]; regulation of protein stability [GO:0031647]; regulation of SNARE complex assembly [GO:0035542]	axon [GO:0030424]; cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; presynapse [GO:0098793]; septin complex [GO:0031105]; septin ring [GO:0005940]; synaptic vesicle membrane [GO:0030672]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]	axon [GO:0030424]; cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; presynapse [GO:0098793]; septin complex [GO:0031105]; septin ring [GO:0005940]; synaptic vesicle membrane [GO:0030672]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]; cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of intracellular protein transport [GO:0033157]; regulation of protein stability [GO:0031647]; regulation of SNARE complex assembly [GO:0035542]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasm, cytoskeleton {ECO:0000250}. Synapse {ECO:0000250|UniProtKB:B0BNF1}. Cell projection, axon {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:B0BNF1}. Presynapse {ECO:0000250|UniProtKB:B0BNF1}. Note=Expressed in axons of immature neurons, localizes to synapses in mature neurons (By similarity). In platelets, found in areas surrounding alpha-granules (PubMed:15116257). {ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.
Q92600	reviewed	CNOT9_HUMAN	CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1)	CNOT9 RCD1 RQCD1	Homo sapiens (Human)	299	FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. {ECO:0000250, ECO:0000269|PubMed:17189474, ECO:0000269|PubMed:18180299}.		cytokine-mediated signaling pathway [GO:0019221]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulatory ncRNA-mediated gene silencing [GO:0031047]; sex differentiation [GO:0007548]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]	epidermal growth factor receptor binding [GO:0005154]; kinase binding [GO:0019900]; nuclear receptor coactivator activity [GO:0030374]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; epidermal growth factor receptor binding [GO:0005154]; kinase binding [GO:0019900]; nuclear receptor coactivator activity [GO:0030374]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; cytokine-mediated signaling pathway [GO:0019221]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulatory ncRNA-mediated gene silencing [GO:0031047]; sex differentiation [GO:0007548]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JKY0}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9JKY0}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250|UniProtKB:Q9JKY0}.
Q92604	reviewed	LGAT1_HUMAN	Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (2-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.62) (Acyl-CoA:monoacylglycerol acyltransferase LPGAT1) (EC 2.3.1.22) (Lysophospholipid acyltransferase 7) (LPLAT7) (EC 2.3.1.-) (Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase)	LPGAT1 FAM34A KIAA0205	Homo sapiens (Human)	370	FUNCTION: Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (By similarity). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor (PubMed:36049524). Acts in concert with an unknown phospholipase A1 to convert palmitate phosphatidylethanolamine (PE) species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (By similarity). Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors (PubMed:15485873). Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (By similarity). Has no activity toward lysophosphatidic acids (LPA) (By similarity). {ECO:0000250|UniProtKB:Q91YX5, ECO:0000269|PubMed:15485873, ECO:0000269|PubMed:36049524}.		phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phospholipid biosynthetic process [GO:0008654]; positive regulation of fatty acid biosynthetic process [GO:0045723]; triglyceride biosynthetic process [GO:0019432]	cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 2-acylglycerol O-acyltransferase activity [GO:0003846]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; 2-acylglycerophosphocholine O-acyltransferase activity [GO:0047190]; acyltransferase activity [GO:0016746]; lysophosphatidylethanolamine acyltransferase activity [GO:0071618]; lysophospholipid acyltransferase activity [GO:0071617]	cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 2-acylglycerol O-acyltransferase activity [GO:0003846]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; 2-acylglycerophosphocholine O-acyltransferase activity [GO:0047190]; acyltransferase activity [GO:0016746]; lysophosphatidylethanolamine acyltransferase activity [GO:0071618]; lysophospholipid acyltransferase activity [GO:0071617]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phospholipid biosynthetic process [GO:0008654]; positive regulation of fatty acid biosynthetic process [GO:0045723]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15485873}; Multi-pass membrane protein {ECO:0000269|PubMed:15485873}.
Q92608	reviewed	DOCK2_HUMAN	Dedicator of cytokinesis protein 2	DOCK2 KIAA0209	Homo sapiens (Human)	1830	FUNCTION: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}.	MISCELLANEOUS: [Isoform 2]: Splicing donor and acceptor sites between exon 6 and exon 7 are not canonical. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; alpha-beta T cell proliferation [GO:0046633]; cell migration [GO:0016477]; chemotaxis [GO:0006935]; establishment of T cell polarity [GO:0001768]; immunological synapse formation [GO:0001771]; macropinocytosis [GO:0044351]; membrane raft polarization [GO:0001766]; myeloid dendritic cell activation involved in immune response [GO:0002277]; myoblast fusion [GO:0007520]; negative thymic T cell selection [GO:0045060]; positive regulation of phagocytosis [GO:0050766]; positive thymic T cell selection [GO:0045059]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; T cell receptor binding [GO:0042608]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; T cell receptor binding [GO:0042608]; actin cytoskeleton organization [GO:0030036]; alpha-beta T cell proliferation [GO:0046633]; cell migration [GO:0016477]; chemotaxis [GO:0006935]; establishment of T cell polarity [GO:0001768]; immunological synapse formation [GO:0001771]; macropinocytosis [GO:0044351]; membrane raft polarization [GO:0001766]; myeloid dendritic cell activation involved in immune response [GO:0002277]; myoblast fusion [GO:0007520]; negative thymic T cell selection [GO:0045060]; positive regulation of phagocytosis [GO:0050766]; positive thymic T cell selection [GO:0045059]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:12393632}; Peripheral membrane protein {ECO:0000269|PubMed:12393632}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12393632}. Note=Colocalizes with F-actin.
Q92609	reviewed	TBCD5_HUMAN	TBC1 domain family member 5	TBC1D5 KIAA0210	Homo sapiens (Human)	795	FUNCTION: May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}.		autophagy [GO:0006914]; macroautophagy [GO:0016236]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; response to starvation [GO:0042594]; retrograde transport, endosome to Golgi [GO:0042147]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; retromer complex [GO:0030904]	AP-2 adaptor complex binding [GO:0035612]; GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877]; retromer complex binding [GO:1905394]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; retromer complex [GO:0030904]; AP-2 adaptor complex binding [GO:0035612]; GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877]; retromer complex binding [GO:1905394]; autophagy [GO:0006914]; macroautophagy [GO:0016236]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; response to starvation [GO:0042594]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:20923837}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:22354992}. Note=During starvation induced autophagy is relocalized from endosomal localization to LC3-positive autophagosomes. {ECO:0000269|PubMed:22354992}.
Q92611	reviewed	EDEM1_HUMAN	ER degradation-enhancing alpha-mannosidase-like protein 1	EDEM1 EDEM KIAA0212	Homo sapiens (Human)	657	FUNCTION: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. {ECO:0000269|PubMed:12610306, ECO:0000269|PubMed:19524542, ECO:0000269|PubMed:19934218, ECO:0000269|PubMed:25092655}.		carbohydrate metabolic process [GO:0005975]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; protein targeting to ER [GO:0045047]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent glycoprotein ERAD pathway [GO:0097466]	aggresome [GO:0016235]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]	calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]; misfolded protein binding [GO:0051787]	aggresome [GO:0016235]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]; misfolded protein binding [GO:0051787]; carbohydrate metabolic process [GO:0005975]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; protein targeting to ER [GO:0045047]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent glycoprotein ERAD pathway [GO:0097466]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19934218}; Single-pass type II membrane protein {ECO:0000269|PubMed:19934218}.
Q92613	reviewed	JADE3_HUMAN	Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16)	JADE3 KIAA0215 PHF16	Homo sapiens (Human)	823	FUNCTION: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}.		regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]	histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q92614	reviewed	MY18A_HUMAN	Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)	MYO18A CD245 KIAA0216 MYSPDZ TIAF1	Homo sapiens (Human)	2054	FUNCTION: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.		actomyosin structure organization [GO:0031032]; asymmetric Golgi ribbon formation [GO:0090164]; cell migration [GO:0016477]; DNA metabolic process [GO:0006259]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi vesicle budding [GO:0048194]; negative regulation of apoptotic process [GO:0043066]; positive regulation of opsonization [GO:1903028]; positive regulation of protein secretion [GO:0050714]; regulation of macrophage activation [GO:0043030]	actomyosin [GO:0042641]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; trans-Golgi network [GO:0005802]	actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; RNA binding [GO:0003723]	actomyosin [GO:0042641]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; trans-Golgi network [GO:0005802]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; actomyosin structure organization [GO:0031032]; asymmetric Golgi ribbon formation [GO:0090164]; cell migration [GO:0016477]; DNA metabolic process [GO:0006259]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi vesicle budding [GO:0048194]; negative regulation of apoptotic process [GO:0043066]; positive regulation of opsonization [GO:1903028]; positive regulation of protein secretion [GO:0050714]; regulation of macrophage activation [GO:0043030]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:19837035}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19837035}. Golgi outpost {ECO:0000250|UniProtKB:D3ZFD0}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:D3ZFD0}. Note=Recruited to the Golgi apparatus by GOLPH3 (PubMed:19837035). Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity). {ECO:0000250|UniProtKB:D3ZFD0, ECO:0000269|PubMed:19837035}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:Q9JMH9}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9JMH9}. Note=Colocalizes with actin. {ECO:0000250|UniProtKB:Q9JMH9}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:12761286}. Note=Lacks the PDZ domain (PubMed:12761286). Diffusely localized in the cytoplasm (PubMed:12761286). {ECO:0000269|PubMed:12761286}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell surface {ECO:0000269|PubMed:16087679}.
Q92615	reviewed	LAR4B_HUMAN	La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5)	LARP4B KIAA0217 LARP5	Homo sapiens (Human)	738	FUNCTION: Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}.		positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; positive regulation of translation [GO:0045727]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; polysomal ribosome [GO:0042788]	mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; polysomal ribosome [GO:0042788]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; positive regulation of translation [GO:0045727]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20573744}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs in response to arsenite treatment. {ECO:0000269|PubMed:20573744}.
Q92616	reviewed	GCN1_HUMAN	Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1)	GCN1 GCN1L1 KIAA0219	Homo sapiens (Human)	2671	FUNCTION: Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:32610081, PubMed:36638793). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (PubMed:36638793). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (PubMed:36638793). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). {ECO:0000250|UniProtKB:E9PVA8, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:36638793}.		cellular response to amino acid starvation [GO:0034198]; cellular response to leucine starvation [GO:1990253]; GCN2-mediated signaling [GO:0140469]; regulation of translation [GO:0006417]; rescue of stalled ribosome [GO:0072344]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; polysome [GO:0005844]; ribosome [GO:0005840]	cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; protein kinase regulator activity [GO:0019887]; protein serine/threonine kinase activator activity [GO:0043539]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; polysome [GO:0005844]; ribosome [GO:0005840]; cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; protein kinase regulator activity [GO:0019887]; protein serine/threonine kinase activator activity [GO:0043539]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; translation factor activity, RNA binding [GO:0008135]; cellular response to amino acid starvation [GO:0034198]; cellular response to leucine starvation [GO:1990253]; GCN2-mediated signaling [GO:0140469]; regulation of translation [GO:0006417]; rescue of stalled ribosome [GO:0072344]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:E9PVA8}. Note=Associates with ribosomes in undifferentiated neuroblastoma cells and increases after neuronal differentiation. {ECO:0000250|UniProtKB:E9PVA8}.
Q92618	reviewed	ZN516_HUMAN	Zinc finger protein 516	ZNF516 KIAA0222	Homo sapiens (Human)	1163	FUNCTION: Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422). {ECO:0000250|UniProtKB:Q7TSH3, ECO:0000269|PubMed:23446422}.		adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; response to cold [GO:0009409]	nucleus [GO:0005634]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; response to cold [GO:0009409]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7TSH3}.
Q92619	reviewed	HMHA1_HUMAN	Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)]	ARHGAP45 HMHA1 KIAA0223	Homo sapiens (Human)	1136	FUNCTION: Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}.	MISCELLANEOUS: Infusion of lymphocyte from mHag HA-1-negative donors results in a durable remission in mHag HA-1-positive patients with leukemia or multiple myeloma.	regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; secretory granule lumen [GO:0034774]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; secretory granule lumen [GO:0034774]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24086303}. Cell projection, ruffle membrane {ECO:0000269|PubMed:24086303}.
Q92620	reviewed	PRP16_HUMAN	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38)	DHX38 DDX38 KIAA0224 PRP16	Homo sapiens (Human)	1227	FUNCTION: Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131). {ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:9524131, ECO:0000305}.		mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29301961}.
Q92621	reviewed	NU205_HUMAN	Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205)	NUP205 C7orf14 KIAA0225	Homo sapiens (Human)	2012	FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:9348540}.		mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611]; structural constituent of nuclear pore [GO:0017056]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283}; Peripheral membrane protein {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:9348540}. Note=Localized near the center, on both the cytoplasmic and nuclear side, of the NPC core structure. {ECO:0000269|PubMed:15229283}.
Q92622	reviewed	RUBIC_HUMAN	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)	RUBCN KIAA0226	Homo sapiens (Human)	972	FUNCTION: Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}.		autophagy [GO:0006914]; immune system process [GO:0002376]; multivesicular body sorting pathway [GO:0071985]; negative regulation of autophagosome maturation [GO:1901097]; negative regulation of autophagy [GO:0010507]; negative regulation of endocytosis [GO:0045806]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; phagocytosis [GO:0006909]	cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]	phosphatidylinositol phosphate binding [GO:1901981]	cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; phosphatidylinositol phosphate binding [GO:1901981]; autophagy [GO:0006914]; immune system process [GO:0002376]; multivesicular body sorting pathway [GO:0071985]; negative regulation of autophagosome maturation [GO:1901097]; negative regulation of autophagy [GO:0010507]; negative regulation of endocytosis [GO:0045806]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; phagocytosis [GO:0006909]	SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:19270696}. Lysosome {ECO:0000269|PubMed:19270696}. Early endosome {ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20974968}. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
Q92624	reviewed	APBP2_HUMAN	Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1)	APPBP2 KIAA0228 PAT1	Homo sapiens (Human)	585	FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:29775578). The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578). The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron (PubMed:26138980). May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface (PubMed:9843960). {ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:9843960}.		intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	microtubule motor activity [GO:0003777]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; microtubule motor activity [GO:0003777]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11742091}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9843960}. Membrane {ECO:0000269|PubMed:9843960}; Peripheral membrane protein {ECO:0000269|PubMed:9843960}. Note=Associated with membranes and microtubules. {ECO:0000269|PubMed:9843960}.
Q92625	reviewed	ANS1A_HUMAN	Ankyrin repeat and SAM domain-containing protein 1A (Odin)	ANKS1A ANKS1 KIAA0229 ODIN	Homo sapiens (Human)	1134	FUNCTION: Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}.		ephrin receptor signaling pathway [GO:0048013]; neuron remodeling [GO:0016322]; substrate-dependent cell migration [GO:0006929]	cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]	ephrin receptor binding [GO:0046875]	cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; ephrin receptor binding [GO:0046875]; ephrin receptor signaling pathway [GO:0048013]; neuron remodeling [GO:0016322]; substrate-dependent cell migration [GO:0006929]	SUBCELLULAR LOCATION: Cytoplasm. Cell projection {ECO:0000250}. Note=Cytoplasmic before and after growth factor treatment.
Q92626	reviewed	PXDN_HUMAN	Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment]	PXDN KIAA0230 MG50 PRG2 PXD01 VPO VPO1	Homo sapiens (Human)	1479	FUNCTION: Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer (PubMed:18929642, PubMed:22842973, PubMed:27697841, PubMed:28154175, PubMed:19590037, PubMed:25708780, PubMed:25713063, PubMed:34679700). In turns, directly contributes to the collagen IV network-dependent fibronectin/FN and laminin assembly, which is required for full extracellular matrix (ECM)-mediated signaling (PubMed:32543734, PubMed:34679700, PubMed:19590037). Thus, sulfilimine cross-links are essential for growth factor-induced cell proliferation and survival in endothelial cells, an event essential to basement membrane integrity (PubMed:32543734). In addition, through the bromide oxidation, may promote tubulogenesis and induce angiogenesis through ERK1/2, Akt, and FAK pathways (PubMed:25713063). Moreover brominates alpha2 collagen IV chain/COL4A2 at 'Tyr-1485' and leads to bromine enrichment of the basement membranes (PubMed:32571911). In vitro, can also catalyze the two-electron oxidation of thiocyanate and iodide and these two substrates could effectively compete with bromide and thus inhibit the formation of sulfilimine bonds (PubMed:28154175). Binds laminins (PubMed:32485152). May play a role in the organization of eyeball structure and lens development during eye development (By similarity). {ECO:0000250|UniProtKB:Q3UQ28, ECO:0000269|PubMed:18929642, ECO:0000269|PubMed:19590037, ECO:0000269|PubMed:22842973, ECO:0000269|PubMed:25708780, ECO:0000269|PubMed:25713063, ECO:0000269|PubMed:27697841, ECO:0000269|PubMed:28154175, ECO:0000269|PubMed:32485152, ECO:0000269|PubMed:32543734, ECO:0000269|PubMed:32571911, ECO:0000269|PubMed:34679700}.		angiogenesis [GO:0001525]; basement membrane assembly [GO:0070831]; basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; response to oxidative stress [GO:0006979]	basement membrane [GO:0005604]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent [GO:0005201]; heme binding [GO:0020037]; interleukin-1 receptor antagonist activity [GO:0005152]; lactoperoxidase activity [GO:0140825]; laminin-1 binding [GO:0043237]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]	basement membrane [GO:0005604]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; heme binding [GO:0020037]; interleukin-1 receptor antagonist activity [GO:0005152]; lactoperoxidase activity [GO:0140825]; laminin-1 binding [GO:0043237]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]; angiogenesis [GO:0001525]; basement membrane assembly [GO:0070831]; basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18929642, ECO:0000269|PubMed:19590037, ECO:0000269|PubMed:26178375, ECO:0000269|Ref.9}. Endoplasmic reticulum {ECO:0000269|PubMed:19590037, ECO:0000269|PubMed:25708780}. Cell surface {ECO:0000269|PubMed:25708780}. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:Q3UQ28}. Note=Enriched in the peritubular space of fibrotic kidneys. Adheres on the cell surface in 'hot spots' (PubMed:25708780). Only the proteolytically processed PXDN integrates into the extracellular matrix (PubMed:34679700). {ECO:0000269|PubMed:25708780, ECO:0000269|PubMed:34679700}.; SUBCELLULAR LOCATION: [PXDN active fragment]: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:34679700}.
Q92629	reviewed	SGCD_HUMAN	Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)	SGCD	Homo sapiens (Human)	289	FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.		calcium ion homeostasis [GO:0055074]; calcium-mediated signaling [GO:0019722]; cardiac muscle cell contraction [GO:0086003]; cardiac muscle cell development [GO:0055013]; cardiac muscle tissue development [GO:0048738]; coronary vasculature morphogenesis [GO:0060977]; heart contraction [GO:0060047]; muscle organ development [GO:0007517]; protein-containing complex localization [GO:0031503]	cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]		cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; calcium ion homeostasis [GO:0055074]; calcium-mediated signaling [GO:0019722]; cardiac muscle cell contraction [GO:0086003]; cardiac muscle cell development [GO:0055013]; cardiac muscle tissue development [GO:0048738]; coronary vasculature morphogenesis [GO:0060977]; heart contraction [GO:0060047]; muscle organ development [GO:0007517]; protein-containing complex localization [GO:0031503]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
Q92630	reviewed	DYRK2_HUMAN	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)	DYRK2	Homo sapiens (Human)	601	FUNCTION: Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}.		DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; positive regulation of glycogen biosynthetic process [GO:0045725]; protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; smoothened signaling pathway [GO:0007224]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ubiquitin ligase complex [GO:0000151]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; positive regulation of glycogen biosynthetic process [GO:0045725]; protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.
Q92633	reviewed	LPAR1_HUMAN	Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2)	LPAR1 EDG2 LPA1	Homo sapiens (Human)	364	FUNCTION: Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to LPA (By similarity). Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation (PubMed:31204173). Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity). {ECO:0000250|UniProtKB:P61793, ECO:0000269|PubMed:18066075, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19656035, ECO:0000269|PubMed:19733258, ECO:0000269|PubMed:25025571, ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:9070858, ECO:0000305|PubMed:11093753, ECO:0000305|PubMed:9069262}.		activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; bleb assembly [GO:0032060]; cell chemotaxis [GO:0060326]; cellular response to 1-oleoyl-sn-glycerol 3-phosphate [GO:1904566]; cellular response to oxygen levels [GO:0071453]; cerebellum development [GO:0021549]; corpus callosum development [GO:0022038]; G protein-coupled receptor signaling pathway [GO:0007186]; myelination [GO:0042552]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cilium assembly [GO:1902018]; negative regulation of neuron projection development [GO:0010977]; neurogenesis [GO:0022008]; oligodendrocyte development [GO:0014003]; optic nerve development [GO:0021554]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell shape [GO:0008360]; regulation of metabolic process [GO:0019222]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of synaptic vesicle cycle [GO:0098693]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endosome [GO:0005768]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; lysophosphatidic acid binding [GO:0035727]; lysophosphatidic acid receptor activity [GO:0070915]; PDZ domain binding [GO:0030165]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endosome [GO:0005768]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; lysophosphatidic acid binding [GO:0035727]; lysophosphatidic acid receptor activity [GO:0070915]; PDZ domain binding [GO:0030165]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; bleb assembly [GO:0032060]; cell chemotaxis [GO:0060326]; cellular response to 1-oleoyl-sn-glycerol 3-phosphate [GO:1904566]; cellular response to oxygen levels [GO:0071453]; cerebellum development [GO:0021549]; corpus callosum development [GO:0022038]; G protein-coupled receptor signaling pathway [GO:0007186]; myelination [GO:0042552]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cilium assembly [GO:1902018]; negative regulation of neuron projection development [GO:0010977]; neurogenesis [GO:0022008]; oligodendrocyte development [GO:0014003]; optic nerve development [GO:0021554]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell shape [GO:0008360]; regulation of metabolic process [GO:0019222]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of synaptic vesicle cycle [GO:0098693]	SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:25025571}. Cell membrane {ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:25025571, ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:9070858}; Multi-pass membrane protein {ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:26091040}. Endosome {ECO:0000269|PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment. {ECO:0000269|PubMed:19306925}.
Q92636	reviewed	FAN_HUMAN	Protein FAN (Factor associated with neutral sphingomyelinase activation) (Factor associated with N-SMase activation)	NSMAF FAN	Homo sapiens (Human)	917	FUNCTION: Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.		ceramide metabolic process [GO:0006672]; positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	sphingomyelin phosphodiesterase activator activity [GO:0016230]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; sphingomyelin phosphodiesterase activator activity [GO:0016230]; ceramide metabolic process [GO:0006672]; positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165]	
Q92637	reviewed	FCGRB_HUMAN	Putative high affinity immunoglobulin gamma Fc receptor IB (IgG Fc receptor IB) (Fc gamma receptor IB pseudogene) (Fc-gamma RIB) (FcRIB) (hFcgammaRIB)	FCGR1BP FCGR1B IGFRB	Homo sapiens (Human)	280	FUNCTION: May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response. {ECO:0000269|PubMed:1430234, ECO:0000269|PubMed:9881690}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; regulation of immune response [GO:0050776]	clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]	IgG binding [GO:0019864]; immunoglobulin receptor activity [GO:0019763]; transmembrane signaling receptor activity [GO:0004888]	clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]; IgG binding [GO:0019864]; immunoglobulin receptor activity [GO:0019763]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1430234}; Single-pass type I membrane protein {ECO:0000269|PubMed:1430234}.
Q92643	reviewed	GPI8_HUMAN	GPI-anchor transamidase (GPI transamidase) (EC 3.-.-.-) (GPI8 homolog) (hGPI8) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K)	PIGK GPI8	Homo sapiens (Human)	395	FUNCTION: Component of the GPI transamidase complex, necessary for transfer of GPI to proteins (PubMed:34576938). Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. {ECO:0000269|PubMed:34576938}.		attachment of GPI anchor to protein [GO:0016255]; proteolysis [GO:0006508]	endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]	GPI-anchor transamidase activity [GO:0003923]; protein disulfide isomerase activity [GO:0003756]	endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]; GPI-anchor transamidase activity [GO:0003923]; protein disulfide isomerase activity [GO:0003756]; attachment of GPI anchor to protein [GO:0016255]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Single-pass type I membrane protein {ECO:0000269|PubMed:11483512}.
Q92665	reviewed	RT31_HUMAN	Small ribosomal subunit protein mS31 (28S ribosomal protein S31, mitochondrial) (MRP-S31) (S31mt) (Imogen 38)	MRPS31 IMOGN38	Homo sapiens (Human)	395			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279123}.
Q92667	reviewed	AKAP1_HUMAN	A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84)	AKAP1 AKAP149 PRKA1	Homo sapiens (Human)	903	FUNCTION: Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]; antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:O08715}. Mitochondrion {ECO:0000250|UniProtKB:O08715}.
Q92673	reviewed	SORL_HUMAN	Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)	SORL1 C11orf32	Homo sapiens (Human)	2214	FUNCTION: Sorting receptor that directs several proteins to their correct location within the cell (Probable). Along with AP-1 complex, involved Golgi apparatus - endosome sorting (PubMed:17646382). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (PubMed:16174740, PubMed:16407538, PubMed:17855360, PubMed:24523320). May also sort newly produced amyloid-beta peptides to lysosomes for catabolism (PubMed:24523320). Does not affect APP trafficking from the endoplasmic reticulum to Golgi compartments (PubMed:17855360). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor (PubMed:23977241). Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion (PubMed:21994944). Sorting receptor for the GDNF-GFRA1 complex, directing it from the cell surface to endosomes. GDNF is then targeted to lysosomes and degraded, while its receptor GFRA1 recycles back to the cell membrane, resulting in a GDNF clearance pathway. The SORL1-GFRA1 complex further targets RET for endocytosis, but not for degradation, affecting GDNF-induced neurotrophic activities (PubMed:23333276). Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling. In ERBB2-dependent cancer cells, promotes cell proliferation (PubMed:31138794). Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL (PubMed:21385844). Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network (PubMed:18603531). Sorting receptor for the insulin receptor INSR. Promotes recycling of internalized INSR via the Golgi apparatus back to the cell surface, thereby preventing lysosomal INSR catabolism, increasing INSR cell surface expression and strengthening insulin signal reception in adipose tissue. Does not affect INSR internalization (PubMed:27322061). Plays a role in renal ion homeostasis, controlling the phospho-regulation of SLC12A1/NKCC2 by STK39/SPAK kinase and PPP3CB/calcineurin A beta phosphatase, possibly through intracellular sorting of STK39 and PPP3CB (By similarity). Stimulates, via the N-terminal ectodomain, the proliferation and migration of smooth muscle cells, possibly by increasing cell surface expression of the urokinase receptor uPAR/PLAUR. This may promote extracellular matrix proteolysis and hence facilitate cell migration (PubMed:14764453). By acting on the migration of intimal smooth muscle cells, may accelerate intimal thickening following vascular injury (PubMed:14764453). Promotes adhesion of monocytes (PubMed:23486467). Stimulates proliferation and migration of monocytes/macrophages (By similarity). Through its action on intimal smooth muscle cells and macrophages, may accelerate intimal thickening and macrophage foam cell formation in the process of atherosclerosis (By similarity). Regulates hypoxia-enhanced adhesion of hematopoietic stem and progenitor cells to the bone marrow stromal cells via a PLAUR-mediated pathway. This function is mediated by the N-terminal ectodomain (PubMed:23486467). Metabolic regulator, which functions to maintain the adequate balance between lipid storage and oxidation in response to changing environmental conditions, such as temperature and diet. The N-terminal ectodomain negatively regulates adipose tissue energy expenditure, acting through the inhibition the BMP/Smad pathway (By similarity). May regulate signaling by the heterodimeric neurotrophic cytokine CLCF1-CRLF1 bound to the CNTFR receptor by promoting the endocytosis of the tripartite complex CLCF1-CRLF1-CNTFR and lysosomal degradation (PubMed:26858303). May regulate IL6 signaling, decreasing cis signaling, possibly by interfering with IL6-binding to membrane-bound IL6R, while up-regulating trans signaling via soluble IL6R (PubMed:28265003). {ECO:0000250|UniProtKB:O88307, ECO:0000269|PubMed:14764453, ECO:0000269|PubMed:16174740, ECO:0000269|PubMed:16407538, ECO:0000269|PubMed:17646382, ECO:0000269|PubMed:17855360, ECO:0000269|PubMed:18603531, ECO:0000269|PubMed:21385844, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:23486467, ECO:0000269|PubMed:23977241, ECO:0000269|PubMed:24523320, ECO:0000269|PubMed:26858303, ECO:0000269|PubMed:27322061, ECO:0000269|PubMed:28265003, ECO:0000269|PubMed:31138794, ECO:0000305}.	MISCELLANEOUS: There may be a positive correlation of body mass index with levels of SORL1 transcript and SORLA protein in visceral adipose tissue. {ECO:0000269|PubMed:27322061}.	adaptive thermogenesis [GO:1990845]; cell migration [GO:0016477]; diet induced thermogenesis [GO:0002024]; endosome to plasma membrane protein transport [GO:0099638]; insulin receptor recycling [GO:0038020]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902960]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of neurofibrillary tangle assembly [GO:1902997]; negative regulation of neurogenesis [GO:0050768]; negative regulation of protein binding [GO:0032091]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of tau-protein kinase activity [GO:1902948]; negative regulation of triglyceride catabolic process [GO:0010897]; neuropeptide signaling pathway [GO:0007218]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of choline O-acetyltransferase activity [GO:1902771]; positive regulation of early endosome to recycling endosome transport [GO:1902955]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of glial cell-derived neurotrophic factor production [GO:1900168]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to early endosome [GO:1902966]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to Golgi apparatus [GO:0034067]; protein maturation [GO:0051604]; protein retention in Golgi apparatus [GO:0045053]; protein targeting [GO:0006605]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; regulation of smooth muscle cell migration [GO:0014910]	cell surface [GO:0009986]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; neuronal cell body [GO:0043025]; nuclear envelope lumen [GO:0005641]; perinucleolar compartment [GO:0097356]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; transport vesicle membrane [GO:0030658]	amyloid-beta binding [GO:0001540]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; neuropeptide binding [GO:0042923]; small GTPase binding [GO:0031267]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; neuronal cell body [GO:0043025]; nuclear envelope lumen [GO:0005641]; perinucleolar compartment [GO:0097356]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; transport vesicle membrane [GO:0030658]; amyloid-beta binding [GO:0001540]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; neuropeptide binding [GO:0042923]; small GTPase binding [GO:0031267]; transmembrane signaling receptor activity [GO:0004888]; adaptive thermogenesis [GO:1990845]; cell migration [GO:0016477]; diet induced thermogenesis [GO:0002024]; endosome to plasma membrane protein transport [GO:0099638]; insulin receptor recycling [GO:0038020]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902960]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of neurofibrillary tangle assembly [GO:1902997]; negative regulation of neurogenesis [GO:0050768]; negative regulation of protein binding [GO:0032091]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of tau-protein kinase activity [GO:1902948]; negative regulation of triglyceride catabolic process [GO:0010897]; neuropeptide signaling pathway [GO:0007218]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of choline O-acetyltransferase activity [GO:1902771]; positive regulation of early endosome to recycling endosome transport [GO:1902955]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of glial cell-derived neurotrophic factor production [GO:1900168]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to early endosome [GO:1902966]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to Golgi apparatus [GO:0034067]; protein maturation [GO:0051604]; protein retention in Golgi apparatus [GO:0045053]; protein targeting [GO:0006605]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; regulation of smooth muscle cell migration [GO:0014910]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11294867, ECO:0000269|PubMed:16174740, ECO:0000269|PubMed:17855360, ECO:0000269|PubMed:21385844, ECO:0000269|PubMed:21994944}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:17646382, ECO:0000269|PubMed:21385844, ECO:0000269|PubMed:23333276}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:21385844, ECO:0000269|PubMed:23333276}; Single-pass type I membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:16174740, ECO:0000269|PubMed:17646382, ECO:0000269|PubMed:21385844, ECO:0000269|PubMed:31138794}; Single-pass type I membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000269|PubMed:17855360, ECO:0000269|PubMed:31138794}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17855360, ECO:0000269|PubMed:21385844}; Single-pass type I membrane protein {ECO:0000305}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:21385844, ECO:0000269|PubMed:23333276}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:11294867, ECO:0000269|PubMed:14764453, ECO:0000269|PubMed:15053742, ECO:0000269|PubMed:17855360, ECO:0000269|PubMed:21385844, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:31138794}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:21994944}; Single-pass type I membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:11082041, ECO:0000269|PubMed:14764453, ECO:0000269|PubMed:15053742, ECO:0000269|PubMed:16393139, ECO:0000269|PubMed:16531402}. Note=Mostly intracellular, predominantly in the trans-Golgi network (TGN) and in endosome, as well as in endosome-to-TGN retrograde vesicles; found at low levels on the plasma membrane (PubMed:11294867, PubMed:15053742, PubMed:17855360, PubMed:21994944, PubMed:21385844, PubMed:31138794). At the cell surface, partially subjected to proteolytic shedding that releases the ectodomain (also called soluble SORLA, solLR11 or sLR11) in the extracellular milieu (PubMed:11082041, PubMed:16393139, PubMed:16531402). The shedding may be catalyzed by ADAM17/TACE (PubMed:16393139). Following shedding, PSEN1/presenilin-1 cleaves the remaining transmembrane fragment and catalyzes the release of a C-terminal fragment in the cytosol and of a soluble N-terminal beta fragment in the extracellular milieu. The C-terminal cytosolic fragment localizes to the nucleus (PubMed:16531402). At the cell surface, the full-length protein undergoes partial clathrin-dependent endocytosis guided by clathrin adapter protein 2 (AP-2) (PubMed:11294867, PubMed:15053742, PubMed:17646382). {ECO:0000269|PubMed:11082041, ECO:0000269|PubMed:11294867, ECO:0000269|PubMed:15053742, ECO:0000269|PubMed:16393139, ECO:0000269|PubMed:16531402, ECO:0000269|PubMed:17646382, ECO:0000269|PubMed:17855360, ECO:0000269|PubMed:21385844, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:31138794}.
Q92674	reviewed	CENPI_HUMAN	Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1)	CENPI FSHPRH1 ICEN19 LRPR1	Homo sapiens (Human)	756	FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. {ECO:0000269|PubMed:12640463, ECO:0000269|PubMed:16622420}.		CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; mitotic sister chromatid segregation [GO:0000070]; sex differentiation [GO:0007548]	cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; mitotic sister chromatid segregation [GO:0000070]; sex differentiation [GO:0007548]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Q92681	reviewed	RSCA1_HUMAN	Regulatory solute carrier protein family 1 member 1 (Transporter regulator RS1) (hRS1)	RSC1A1	Homo sapiens (Human)	617	FUNCTION: Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network. {ECO:0000269|PubMed:14724758, ECO:0000269|PubMed:16788146, ECO:0000269|PubMed:8836035}.		negative regulation of glucose transmembrane transport [GO:0010829]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; negative regulation of nucleoside transport [GO:0032243]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of transport [GO:0051051]	cell junction [GO:0030054]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	sodium channel inhibitor activity [GO:0019871]	cell junction [GO:0030054]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sodium channel inhibitor activity [GO:0019871]; negative regulation of glucose transmembrane transport [GO:0010829]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; negative regulation of nucleoside transport [GO:0032243]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of transport [GO:0051051]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16788147}. Nucleus {ECO:0000269|PubMed:16788147}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:16788147}. Note=Localizes at the inner side of the plasma membrane.
Q92685	reviewed	ALG3_HUMAN	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Asparagine-linked glycosylation protein 3 homolog) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase) (Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase) (Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase) (Not56-like protein)	ALG3 NOT NOT56L	Homo sapiens (Human)	438	FUNCTION: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. {ECO:0000269|PubMed:10581255}.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	alpha-1,3-mannosyltransferase activity [GO:0000033]; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0052925]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; alpha-1,3-mannosyltransferase activity [GO:0000033]; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0052925]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q92688	reviewed	AN32B_HUMAN	Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29)	ANP32B APRIL PHAPI2	Homo sapiens (Human)	251	FUNCTION: Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:20015864, PubMed:18039846). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:20538007, PubMed:18039846). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:33045004, PubMed:31217244). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}.	MISCELLANEOUS: [Isoform 2]: No canonical donor splice site. {ECO:0000305}.	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; inner ear development [GO:0048839]; negative regulation of cell differentiation [GO:0045596]; nucleosome assembly [GO:0006334]; positive regulation of protein export from nucleus [GO:0046827]; regulation of apoptotic process [GO:0042981]; roof of mouth development [GO:0060021]; vasculature development [GO:0001944]; ventricular system development [GO:0021591]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone binding [GO:0042393]; RNA polymerase binding [GO:0070063]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone binding [GO:0042393]; RNA polymerase binding [GO:0070063]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; inner ear development [GO:0048839]; negative regulation of cell differentiation [GO:0045596]; nucleosome assembly [GO:0006334]; positive regulation of protein export from nucleus [GO:0046827]; regulation of apoptotic process [GO:0042981]; roof of mouth development [GO:0060021]; vasculature development [GO:0001944]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:24823948, ECO:0000269|PubMed:31217244}. Cytoplasm {ECO:0000269|PubMed:17178712}. Note=Accumulates in the nuclei at the S phase. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Lacks a nuclear localization signal.
Q92692	reviewed	NECT2_HUMAN	Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)	NECTIN2 HVEB PRR2 PVRL2	Homo sapiens (Human)	538	FUNCTION: Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}.		acrosome assembly [GO:0001675]; adhesion of symbiont to host [GO:0044406]; cell part morphogenesis [GO:0032990]; cilium organization [GO:0044782]; coreceptor-mediated virion attachment to host cell [GO:0046814]; cytoskeleton organization [GO:0007010]; establishment of localization in cell [GO:0051649]; establishment of mitochondrion localization [GO:0051654]; fertilization [GO:0009566]; fusion of virus membrane with host plasma membrane [GO:0019064]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of immunoglobulin mediated immune response [GO:0002891]; positive regulation of mast cell activation [GO:0033005]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of viral entry into host cell [GO:0046596]; sperm mitochondrion organization [GO:0030382]; spermatid development [GO:0007286]; spermatid nucleus differentiation [GO:0007289]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271]; susceptibility to T cell mediated cytotoxicity [GO:0060370]	apical junction complex [GO:0043296]; cell surface [GO:0009986]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; zonula adherens [GO:0005915]	cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; virus receptor activity [GO:0001618]	apical junction complex [GO:0043296]; cell surface [GO:0009986]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; zonula adherens [GO:0005915]; cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; virus receptor activity [GO:0001618]; acrosome assembly [GO:0001675]; adhesion of symbiont to host [GO:0044406]; cell part morphogenesis [GO:0032990]; cilium organization [GO:0044782]; coreceptor-mediated virion attachment to host cell [GO:0046814]; cytoskeleton organization [GO:0007010]; establishment of localization in cell [GO:0051649]; establishment of mitochondrion localization [GO:0051654]; fertilization [GO:0009566]; fusion of virus membrane with host plasma membrane [GO:0019064]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of immunoglobulin mediated immune response [GO:0002891]; positive regulation of mast cell activation [GO:0033005]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of viral entry into host cell [GO:0046596]; sperm mitochondrion organization [GO:0030382]; spermatid development [GO:0007286]; spermatid nucleus differentiation [GO:0007289]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271]; susceptibility to T cell mediated cytotoxicity [GO:0060370]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q92696	reviewed	PGTA_HUMAN	Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha)	RABGGTA	Homo sapiens (Human)	567	FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. {ECO:0000269|PubMed:7991565}.		protein geranylgeranylation [GO:0018344]; protein modification process [GO:0036211]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; Rab-protein geranylgeranyltransferase complex [GO:0005968]	Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; Rab-protein geranylgeranyltransferase complex [GO:0005968]; Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]; protein geranylgeranylation [GO:0018344]; protein modification process [GO:0036211]; visual perception [GO:0007601]	
Q92698	reviewed	RAD54_HUMAN	DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54)	RAD54L RAD54A	Homo sapiens (Human)	747	FUNCTION: Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:9774452, PubMed:24798879, PubMed:32457312, PubMed:11459989, PubMed:12205100, PubMed:27264870). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). {ECO:0000250|UniProtKB:P32863, ECO:0000269|PubMed:11459989, ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:24798879, ECO:0000269|PubMed:27264870, ECO:0000269|PubMed:32457312, ECO:0000269|PubMed:9774452}.		chromosome organization [GO:0051276]; determination of adult lifespan [GO:0008340]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; meiotic cell cycle [GO:0051321]; reciprocal meiotic recombination [GO:0007131]; response to ionizing radiation [GO:0010212]; response to xenobiotic stimulus [GO:0009410]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; DNA translocase activity [GO:0015616]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; DNA translocase activity [GO:0015616]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; chromosome organization [GO:0051276]; determination of adult lifespan [GO:0008340]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; meiotic cell cycle [GO:0051321]; reciprocal meiotic recombination [GO:0007131]; response to ionizing radiation [GO:0010212]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8805304}.
Q92729	reviewed	PTPRU_HUMAN	Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi)	PTPRU FMI PCP2 PTPRO	Homo sapiens (Human)	1446	FUNCTION: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12501215, ECO:0000269|PubMed:16574648}.		animal organ regeneration [GO:0031100]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; homotypic cell-cell adhesion [GO:0034109]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; response to glucocorticoid [GO:0051384]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]	cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]	beta-catenin binding [GO:0008013]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; animal organ regeneration [GO:0031100]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; homotypic cell-cell adhesion [GO:0034109]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; response to glucocorticoid [GO:0051384]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]	SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:8700514}. Cell membrane {ECO:0000269|PubMed:8700514}; Single-pass type I membrane protein {ECO:0000269|PubMed:8700514}.
Q92730	reviewed	RND1_HUMAN	Rho-related GTP-binding protein Rho6 (Rho family GTPase 1) (Rnd1)	RND1 RHO6	Homo sapiens (Human)	232	FUNCTION: Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. {ECO:0000269|PubMed:11095956}.		actin filament organization [GO:0007015]; cell migration [GO:0016477]; negative regulation of cell adhesion [GO:0007162]; neuron remodeling [GO:0016322]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; signaling receptor binding [GO:0005102]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; signaling receptor binding [GO:0005102]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; negative regulation of cell adhesion [GO:0007162]; neuron remodeling [GO:0016322]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11940653}; Lipid-anchor {ECO:0000269|PubMed:11940653}; Cytoplasmic side {ECO:0000269|PubMed:11940653}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11940653}.
Q92731	reviewed	ESR2_HUMAN	Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)	ESR2 ESTRB NR3A2	Homo sapiens (Human)	530	FUNCTION: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:29261182, ECO:0000269|PubMed:30113650, ECO:0000269|PubMed:9325313}.; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {ECO:0000269|PubMed:9671811}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Does not form homodimers. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Does not form homodimers. {ECO:0000305}.	cell-cell signaling [GO:0007267]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; intracellular estrogen receptor signaling pathway [GO:0030520]; negative regulation of cell growth [GO:0030308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; nuclear estrogen receptor activity [GO:0030284]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; receptor antagonist activity [GO:0048019]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; nuclear estrogen receptor activity [GO:0030284]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; receptor antagonist activity [GO:0048019]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]; cell-cell signaling [GO:0007267]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; intracellular estrogen receptor signaling pathway [GO:0030520]; negative regulation of cell growth [GO:0030308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:19126643, ECO:0000269|PubMed:20074560}.
Q92733	reviewed	PRCC_HUMAN	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein)	PRCC TPRC	Homo sapiens (Human)	491	FUNCTION: May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269|PubMed:11717438}.		cell cycle [GO:0007049]; regulation of cell cycle [GO:0051726]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell cycle [GO:0007049]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11717438}.
Q92734	reviewed	TFG_HUMAN	Protein TFG (TRK-fused gene protein)	TFG	Homo sapiens (Human)	400	FUNCTION: Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}.		COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; intracellular membrane-bounded organelle [GO:0043231]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; intracellular membrane-bounded organelle [GO:0043231]; identical protein binding [GO:0042802]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:27813252}. Note=Localizes to endoplasmic reticulum exit site (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:27813252, PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:27813252}.
Q92736	reviewed	RYR2_HUMAN	Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)	RYR2	Homo sapiens (Human)	4967	FUNCTION: Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:17984046, ECO:0000269|PubMed:20056922, ECO:0000269|PubMed:27733687, ECO:0000269|PubMed:33536282}.		calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; calcium-mediated signaling [GO:0019722]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to caffeine [GO:0071313]; cellular response to epinephrine stimulus [GO:0071872]; detection of calcium ion [GO:0005513]; embryonic heart tube morphogenesis [GO:0003143]; establishment of localization in cell [GO:0051649]; establishment of protein localization to endoplasmic reticulum [GO:0072599]; intracellular calcium ion homeostasis [GO:0006874]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; positive regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901896]; positive regulation of heart rate [GO:0010460]; positive regulation of sequestering of calcium ion [GO:0051284]; positive regulation of the force of heart contraction [GO:0098735]; Purkinje myocyte to ventricular cardiac muscle cell signaling [GO:0086029]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of AV node cell action potential [GO:0098904]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to caffeine [GO:0031000]; response to hypoxia [GO:0001666]; response to muscle activity [GO:0014850]; response to muscle stretch [GO:0035994]; response to redox state [GO:0051775]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; striated muscle contraction [GO:0006941]; type B pancreatic cell apoptotic process [GO:0097050]; ventricular cardiac muscle cell action potential [GO:0086005]	calcium channel complex [GO:0034704]; junctional sarcoplasmic reticulum membrane [GO:0014701]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calcium-release channel activity [GO:0015278]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; protein self-association [GO:0043621]; ryanodine-sensitive calcium-release channel activity [GO:0005219]; suramin binding [GO:0043924]; transmembrane transporter binding [GO:0044325]	calcium channel complex [GO:0034704]; junctional sarcoplasmic reticulum membrane [GO:0014701]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calcium-release channel activity [GO:0015278]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; protein self-association [GO:0043621]; ryanodine-sensitive calcium-release channel activity [GO:0005219]; suramin binding [GO:0043924]; transmembrane transporter binding [GO:0044325]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; calcium-mediated signaling [GO:0019722]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to caffeine [GO:0071313]; cellular response to epinephrine stimulus [GO:0071872]; detection of calcium ion [GO:0005513]; embryonic heart tube morphogenesis [GO:0003143]; establishment of localization in cell [GO:0051649]; establishment of protein localization to endoplasmic reticulum [GO:0072599]; intracellular calcium ion homeostasis [GO:0006874]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; positive regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901896]; positive regulation of heart rate [GO:0010460]; positive regulation of sequestering of calcium ion [GO:0051284]; positive regulation of the force of heart contraction [GO:0098735]; Purkinje myocyte to ventricular cardiac muscle cell signaling [GO:0086029]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of AV node cell action potential [GO:0098904]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to caffeine [GO:0031000]; response to hypoxia [GO:0001666]; response to muscle activity [GO:0014850]; response to muscle stretch [GO:0035994]; response to redox state [GO:0051775]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; striated muscle contraction [GO:0006941]; type B pancreatic cell apoptotic process [GO:0097050]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:10830164}; Multi-pass membrane protein {ECO:0000269|PubMed:10830164}.
Q92737	reviewed	RSLAA_HUMAN	Ras-like protein family member 10A (EC 3.6.5.2) (Ras-like protein RRP22) (Ras-related protein on chromosome 22)	RASL10A RRP22	Homo sapiens (Human)	203	FUNCTION: Potent inhibitor of cellular proliferation. {ECO:0000269|PubMed:15833841}.		small GTPase mediated signal transduction [GO:0007264]	nucleolus [GO:0005730]; plasma membrane [GO:0005886]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	nucleolus [GO:0005730]; plasma membrane [GO:0005886]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Nucleus, nucleolus {ECO:0000269|PubMed:15833841}. Note=May cycle in and out of the nucleolus in a GTP-dependent manner.
Q92738	reviewed	US6NL_HUMAN	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre)	USP6NL KIAA0019	Homo sapiens (Human)	828	FUNCTION: Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}.		Golgi organization [GO:0007030]; plasma membrane to endosome transport [GO:0048227]; positive regulation of GTPase activity [GO:0043547]; regulation of Golgi organization [GO:1903358]; retrograde transport, plasma membrane to Golgi [GO:0035526]; virion assembly [GO:0019068]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; Golgi organization [GO:0007030]; plasma membrane to endosome transport [GO:0048227]; positive regulation of GTPase activity [GO:0043547]; regulation of Golgi organization [GO:1903358]; retrograde transport, plasma membrane to Golgi [GO:0035526]; virion assembly [GO:0019068]	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle.
Q92743	reviewed	HTRA1_HUMAN	Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11)	HTRA1 HTRA PRSS11	Homo sapiens (Human)	480	FUNCTION: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. {ECO:0000269|PubMed:16377621, ECO:0000269|PubMed:20671064, ECO:0000269|PubMed:9852107}.		chorionic trophoblast cell differentiation [GO:0060718]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; programmed cell death [GO:0012501]; proteolysis [GO:0006508]	collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; molecular function activator activity [GO:0140677]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; molecular function activator activity [GO:0140677]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; chorionic trophoblast cell differentiation [GO:0060718]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; programmed cell death [GO:0012501]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21297635}. Secreted {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:9852107}. Cytoplasm, cytosol {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:20671064}. Note=Predominantly secreted (PubMed:15208355). Also found associated with the plasma membrane (PubMed:21297635). {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:21297635}.
Q92748	reviewed	THRSP_HUMAN	Thyroid hormone-inducible hepatic protein (Spot 14 protein) (S14) (SPOT14)	THRSP	Homo sapiens (Human)	146	FUNCTION: Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB. {ECO:0000250, ECO:0000269|PubMed:17418816, ECO:0000269|PubMed:18299245}.		lipid metabolic process [GO:0006629]; regulation of lipid biosynthetic process [GO:0046890]; regulation of triglyceride biosynthetic process [GO:0010866]; response to bacterium [GO:0009617]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; protein homodimerization activity [GO:0042803]; lipid metabolic process [GO:0006629]; regulation of lipid biosynthetic process [GO:0046890]; regulation of triglyceride biosynthetic process [GO:0010866]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18299245}. Cytoplasm {ECO:0000269|PubMed:18299245}.
Q92750	reviewed	TAF4B_HUMAN	Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105)	TAF4B TAF2C2 TAFII105	Homo sapiens (Human)	862	FUNCTION: Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. {ECO:0000250|UniProtKB:G5E8Z2, ECO:0000269|PubMed:10828057, ECO:0000269|PubMed:10849440, ECO:0000269|PubMed:16088961, ECO:0000303|PubMed:24431330}.	MISCELLANEOUS: [Isoform 2]: May be due to exon inclusion. Unphosphorylated form. {ECO:0000305}.	mRNA transcription by RNA polymerase II [GO:0042789]; oogenesis [GO:0048477]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermatogenesis [GO:0007283]; transcription initiation at RNA polymerase II promoter [GO:0006367]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]	DNA binding [GO:0003677]; NF-kappaB binding [GO:0051059]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; DNA binding [GO:0003677]; NF-kappaB binding [GO:0051059]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; mRNA transcription by RNA polymerase II [GO:0042789]; oogenesis [GO:0048477]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermatogenesis [GO:0007283]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11567023, ECO:0000269|PubMed:16088961}. Cytoplasm {ECO:0000269|PubMed:11567023, ECO:0000269|PubMed:16088961}. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation. {ECO:0000269|PubMed:11567023}.
Q92752	reviewed	TENR_HUMAN	Tenascin-R (TN-R) (Janusin) (Restrictin)	TNR	Homo sapiens (Human)	1358	FUNCTION: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). {ECO:0000250}.		associative learning [GO:0008306]; axon extension involved in regeneration [GO:0048677]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neuron projection development [GO:0010977]; negative regulation of synaptic transmission [GO:0050805]; neuroblast migration [GO:0097402]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of cell migration [GO:0030334]; synapse organization [GO:0050808]; synaptic transmission, glutamatergic [GO:0035249]; telencephalon cell migration [GO:0022029]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; perineuronal net [GO:0072534]; Schaffer collateral - CA1 synapse [GO:0098685]; tenascin complex [GO:0090733]		cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; perineuronal net [GO:0072534]; Schaffer collateral - CA1 synapse [GO:0098685]; tenascin complex [GO:0090733]; associative learning [GO:0008306]; axon extension involved in regeneration [GO:0048677]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neuron projection development [GO:0010977]; negative regulation of synaptic transmission [GO:0050805]; neuroblast migration [GO:0097402]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of cell migration [GO:0030334]; synapse organization [GO:0050808]; synaptic transmission, glutamatergic [GO:0035249]; telencephalon cell migration [GO:0022029]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q92753	reviewed	RORB_HUMAN	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)	RORB NR1F2 RZRB	Homo sapiens (Human)	470	FUNCTION: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P45446}.; FUNCTION: Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity). {ECO:0000250|UniProtKB:Q8R1B8}.		amacrine cell differentiation [GO:0035881]; cellular response to retinoic acid [GO:0071300]; eye photoreceptor cell development [GO:0042462]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; rhythmic process [GO:0048511]; visual perception [GO:0007601]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; melatonin receptor activity [GO:0008502]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; melatonin receptor activity [GO:0008502]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; amacrine cell differentiation [GO:0035881]; cellular response to retinoic acid [GO:0071300]; eye photoreceptor cell development [GO:0042462]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; rhythmic process [GO:0048511]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:27352968}.
Q92754	reviewed	AP2C_HUMAN	Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1)	TFAP2C	Homo sapiens (Human)	450	FUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}.		anatomical structure development [GO:0048856]; cell-cell signaling [GO:0007267]; male gonad development [GO:0008584]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure development [GO:0048856]; cell-cell signaling [GO:0007267]; male gonad development [GO:0008584]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24413532}.
Q92759	reviewed	TF2H4_HUMAN	General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit)	GTF2H4	Homo sapiens (Human)	462	FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000269|PubMed:9852112}.		DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; transcription by RNA polymerase II [GO:0006366]	core TFIIH complex portion of holo TFIIH complex [GO:0000438]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]	ATPase activator activity [GO:0001671]; double-stranded DNA binding [GO:0003690]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	core TFIIH complex portion of holo TFIIH complex [GO:0000438]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; ATPase activator activity [GO:0001671]; double-stranded DNA binding [GO:0003690]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
Q92764	reviewed	KRT35_HUMAN	Keratin, type I cuticular Ha5 (Hair keratin, type I Ha5) (Keratin-35) (K35)	KRT35 HHA5 HKA5 KRTHA5	Homo sapiens (Human)	455		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	anatomical structure morphogenesis [GO:0009653]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; anatomical structure morphogenesis [GO:0009653]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
Q92765	reviewed	SFRP3_HUMAN	Secreted frizzled-related protein 3 (sFRP-3) (Frezzled) (Fritz) (Frizzled-related protein 1) (FrzB-1)	FRZB FIZ FRE FRP FRZB1 SFRP3	Homo sapiens (Human)	325	FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.		canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; convergent extension involved in organogenesis [GO:0060029]; epithelial cell development [GO:0002064]; hepatocyte differentiation [GO:0070365]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell development [GO:0010721]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hepatocyte differentiation [GO:0070367]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell differentiation [GO:0014033]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fat cell differentiation [GO:0045600]; skeletal system development [GO:0001501]; somite development [GO:0061053]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]	Wnt-protein binding [GO:0017147]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]; Wnt-protein binding [GO:0017147]; canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; convergent extension involved in organogenesis [GO:0060029]; epithelial cell development [GO:0002064]; hepatocyte differentiation [GO:0070365]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell development [GO:0010721]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hepatocyte differentiation [GO:0070367]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell differentiation [GO:0014033]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fat cell differentiation [GO:0045600]; skeletal system development [GO:0001501]; somite development [GO:0061053]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q92766	reviewed	RREB1_HUMAN	Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1)	RREB1 FINB	Homo sapiens (Human)	1687	FUNCTION: Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:9305772, PubMed:15067362, PubMed:8816445, PubMed:10390538, PubMed:17550981). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:9305772}.
Q92769	reviewed	HDAC2_HUMAN	Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)	HDAC2	Homo sapiens (Human)	488	FUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674). {ECO:0000250|UniProtKB:P70288, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29192674}.		behavioral response to ethanol [GO:0048149]; cardiac muscle hypertrophy [GO:0003300]; cellular response to dopamine [GO:1903351]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; dendrite development [GO:0016358]; embryonic digit morphogenesis [GO:0042733]; epidermal cell differentiation [GO:0009913]; eyelid development in camera-type eye [GO:0061029]; fungiform papilla formation [GO:0061198]; hair follicle placode formation [GO:0060789]; heterochromatin formation [GO:0031507]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of male mating behavior [GO:1902437]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of proteolysis [GO:0045862]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; response to amphetamine [GO:0001975]; response to caffeine [GO:0031000]; response to cocaine [GO:0042220]; response to hyperoxia [GO:0055093]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; ESC/E(Z) complex [GO:0035098]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; Sin3 complex [GO:0016580]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; histone binding [GO:0042393]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; NF-kappaB binding [GO:0051059]; promoter-specific chromatin binding [GO:1990841]; protein de-2-hydroxyisobutyrylase activity [GO:0160010]; protein lysine deacetylase activity [GO:0033558]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; ESC/E(Z) complex [GO:0035098]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; Sin3 complex [GO:0016580]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; histone binding [GO:0042393]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; NF-kappaB binding [GO:0051059]; promoter-specific chromatin binding [GO:1990841]; protein de-2-hydroxyisobutyrylase activity [GO:0160010]; protein lysine deacetylase activity [GO:0033558]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; behavioral response to ethanol [GO:0048149]; cardiac muscle hypertrophy [GO:0003300]; cellular response to dopamine [GO:1903351]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; dendrite development [GO:0016358]; embryonic digit morphogenesis [GO:0042733]; epidermal cell differentiation [GO:0009913]; eyelid development in camera-type eye [GO:0061029]; fungiform papilla formation [GO:0061198]; hair follicle placode formation [GO:0060789]; heterochromatin formation [GO:0031507]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of male mating behavior [GO:1902437]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of proteolysis [GO:0045862]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; response to amphetamine [GO:0001975]; response to caffeine [GO:0031000]; response to cocaine [GO:0042220]; response to hyperoxia [GO:0055093]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:24970816, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Cytoplasm {ECO:0000269|PubMed:24970816}.
Q92772	reviewed	CDKL2_HUMAN	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Protein kinase p56 KKIAMRE) (Serine/threonine-protein kinase KKIAMRE)	CDKL2	Homo sapiens (Human)	493			phosphorylation [GO:0016310]; sex differentiation [GO:0007548]; signal transduction [GO:0007165]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]; sex differentiation [GO:0007548]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9000130}. Nucleus {ECO:0000269|PubMed:9000130}.
Q92777	reviewed	SYN2_HUMAN	Synapsin-2 (Synapsin II)	SYN2	Homo sapiens (Human)	582	FUNCTION: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity). {ECO:0000250}.		calcium-ion regulated exocytosis [GO:0017156]; chemical synaptic transmission [GO:0007268]; neurotransmitter secretion [GO:0007269]; synaptic vesicle clustering [GO:0097091]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; Schaffer collateral - CA1 synapse [GO:0098685]; SNARE complex [GO:0031201]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; Schaffer collateral - CA1 synapse [GO:0098685]; SNARE complex [GO:0031201]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; calcium-ion regulated exocytosis [GO:0017156]; chemical synaptic transmission [GO:0007268]; neurotransmitter secretion [GO:0007269]; synaptic vesicle clustering [GO:0097091]	SUBCELLULAR LOCATION: Synapse.
Q92781	reviewed	RDH5_HUMAN	Retinol dehydrogenase 5 (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (11-cis retinol dehydrogenase) (11-cis RDH) (11-cis RoDH) (9-cis retinol dehydrogenase) (9cRDH) (Short chain dehydrogenase/reductase family 9C member 5)	RDH5 HSD17B9 RDH1 SDR9C5	Homo sapiens (Human)	318	FUNCTION: Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:11675386, PubMed:10588954, PubMed:9931293, PubMed:9115228). Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (PubMed:9931293, PubMed:29541409). {ECO:0000250|UniProtKB:Q27979, ECO:0000269|PubMed:10588954, ECO:0000269|PubMed:11675386, ECO:0000269|PubMed:29541409, ECO:0000269|PubMed:9115228, ECO:0000269|PubMed:9931293}.		response to stimulus [GO:0050896]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; visual perception [GO:0007601]	cell body [GO:0044297]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	11-cis-retinol dehydrogenase [GO:0106429]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; NAD-retinol dehydrogenase activity [GO:0004745]; protein homodimerization activity [GO:0042803]	cell body [GO:0044297]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; 11-cis-retinol dehydrogenase [GO:0106429]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; NAD-retinol dehydrogenase activity [GO:0004745]; protein homodimerization activity [GO:0042803]; response to stimulus [GO:0050896]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11675386}; Multi-pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000269|PubMed:11675386}.
Q92782	reviewed	DPF1_HUMAN	Zinc finger protein neuro-d4 (BRG1-associated factor 45B) (BAF45B) (D4, zinc and double PHD fingers family 1)	DPF1 BAF45B NEUD4	Homo sapiens (Human)	387	FUNCTION: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}.		apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nBAF complex [GO:0071565]	metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nBAF complex [GO:0071565]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]; apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Q92783	reviewed	STAM1_HUMAN	Signal transducing adapter molecule 1 (STAM-1)	STAM STAM1	Homo sapiens (Human)	540	FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.; FUNCTION: (Microbial infection) Plays an important role in Dengue virus entry. {ECO:0000269|PubMed:29742433}.		macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; positive regulation of exosomal secretion [GO:1903543]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of extracellular exosome assembly [GO:1903551]; signal transduction [GO:0007165]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; ESCRT-0 complex [GO:0033565]; intracellular membrane-bounded organelle [GO:0043231]	phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130]; ubiquitin-like protein ligase binding [GO:0044389]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; ESCRT-0 complex [GO:0033565]; intracellular membrane-bounded organelle [GO:0043231]; phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130]; ubiquitin-like protein ligase binding [GO:0044389]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; positive regulation of exosomal secretion [GO:1903543]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of extracellular exosome assembly [GO:1903551]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}.
Q92784	reviewed	DPF3_HUMAN	Zinc finger protein DPF3 (BRG1-associated factor 45C) (BAF45C) (Zinc finger protein cer-d4)	DPF3 BAF45C CERD4	Homo sapiens (Human)	378	FUNCTION: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. {ECO:0000250, ECO:0000269|PubMed:18765789}.; FUNCTION: [Isoform 2]: Acts as a regulator of myogenesis in cooperation with HDGFL2 (PubMed:32459350). Mediates the interaction of HDGFL2 with the BAF complex (PubMed:32459350). HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). {ECO:0000269|PubMed:32459350}.	MISCELLANEOUS: [Isoform 2]: Lacks PHD-type zinc fingers and does not bind to acetylated histones H3 and H4. {ECO:0000305}.	chromatin remodeling [GO:0006338]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	brahma complex [GO:0035060]; chromatin [GO:0000785]; nBAF complex [GO:0071565]; nucleoplasm [GO:0005654]; SWI/SNF complex [GO:0016514]	zinc ion binding [GO:0008270]	brahma complex [GO:0035060]; chromatin [GO:0000785]; nBAF complex [GO:0071565]; nucleoplasm [GO:0005654]; SWI/SNF complex [GO:0016514]; zinc ion binding [GO:0008270]; chromatin remodeling [GO:0006338]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q92785	reviewed	REQU_HUMAN	Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)	DPF2 BAF45D REQ UBID4	Homo sapiens (Human)	391	FUNCTION: Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}.		apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; chromatin remodeling [GO:0006338]; negative regulation of myeloid progenitor cell differentiation [GO:1905454]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nBAF complex [GO:0071565]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]	H3K9me3 modified histone binding [GO:0062072]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nBAF complex [GO:0071565]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]; H3K9me3 modified histone binding [GO:0062072]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; chromatin remodeling [GO:0006338]; negative regulation of myeloid progenitor cell differentiation [GO:1905454]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28533407, ECO:0000269|PubMed:29429572}. Cytoplasm {ECO:0000269|PubMed:28533407}.
Q92786	reviewed	PROX1_HUMAN	Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1)	PROX1	Homo sapiens (Human)	737	FUNCTION: Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}.		acinar cell differentiation [GO:0090425]; aorta smooth muscle tissue morphogenesis [GO:0060414]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; blood vessel endothelial cell differentiation [GO:0060837]; brain development [GO:0007420]; branching involved in pancreas morphogenesis [GO:0061114]; cerebellar granule cell differentiation [GO:0021707]; circadian rhythm [GO:0007623]; dentate gyrus development [GO:0021542]; dorsal spinal cord development [GO:0021516]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; endocardium formation [GO:0060214]; epithelial cell migration [GO:0010631]; hepatocyte cell migration [GO:0002194]; hepatocyte differentiation [GO:0070365]; hepatocyte proliferation [GO:0072574]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; lens fiber cell morphogenesis [GO:0070309]; lens placode formation involved in camera-type eye formation [GO:0046619]; liver development [GO:0001889]; lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; lymphatic endothelial cell fate commitment [GO:0060838]; negative regulation of bile acid biosynthetic process [GO:0070858]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral genome replication [GO:0045071]; neural tube development [GO:0021915]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; neuronal stem cell population maintenance [GO:0097150]; olfactory placode formation [GO:0030910]; otic placode formation [GO:0043049]; pancreas development [GO:0031016]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell cycle checkpoint [GO:1901978]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of forebrain neuron differentiation [GO:2000979]; positive regulation of heart growth [GO:0060421]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to nutrient levels [GO:0031667]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal muscle thin filament assembly [GO:0030240]; transcription by RNA polymerase II [GO:0006366]; venous blood vessel morphogenesis [GO:0048845]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular cardiac myofibril assembly [GO:0055005]; ventricular septum morphogenesis [GO:0060412]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA binding domain binding [GO:0050692]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; LBD domain binding [GO:0050693]; nuclear receptor binding [GO:0016922]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA binding domain binding [GO:0050692]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; LBD domain binding [GO:0050693]; nuclear receptor binding [GO:0016922]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; acinar cell differentiation [GO:0090425]; aorta smooth muscle tissue morphogenesis [GO:0060414]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; blood vessel endothelial cell differentiation [GO:0060837]; brain development [GO:0007420]; branching involved in pancreas morphogenesis [GO:0061114]; cerebellar granule cell differentiation [GO:0021707]; circadian rhythm [GO:0007623]; dentate gyrus development [GO:0021542]; dorsal spinal cord development [GO:0021516]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; endocardium formation [GO:0060214]; epithelial cell migration [GO:0010631]; hepatocyte cell migration [GO:0002194]; hepatocyte differentiation [GO:0070365]; hepatocyte proliferation [GO:0072574]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; lens fiber cell morphogenesis [GO:0070309]; lens placode formation involved in camera-type eye formation [GO:0046619]; liver development [GO:0001889]; lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; lymphatic endothelial cell fate commitment [GO:0060838]; negative regulation of bile acid biosynthetic process [GO:0070858]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral genome replication [GO:0045071]; neural tube development [GO:0021915]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; neuronal stem cell population maintenance [GO:0097150]; olfactory placode formation [GO:0030910]; otic placode formation [GO:0043049]; pancreas development [GO:0031016]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell cycle checkpoint [GO:1901978]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of forebrain neuron differentiation [GO:2000979]; positive regulation of heart growth [GO:0060421]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to nutrient levels [GO:0031667]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal muscle thin filament assembly [GO:0030240]; transcription by RNA polymerase II [GO:0006366]; venous blood vessel morphogenesis [GO:0048845]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular cardiac myofibril assembly [GO:0055005]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P48437}. Note=RORG promotes its nuclear localization. {ECO:0000250|UniProtKB:P48437}.
Q92791	reviewed	SC65_HUMAN	Endoplasmic reticulum protein SC65 (Leprecan-like protein 4) (Nucleolar autoantigen No55) (Prolyl 3-hydroxylase family member 4) (Synaptonemal complex protein SC65)	P3H4 LEPREL4 NOL55 SC65	Homo sapiens (Human)	437	FUNCTION: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. {ECO:0000250|UniProtKB:Q8K2B0}.		bone remodeling [GO:0046849]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; peptidyl-lysine hydroxylation [GO:0017185]; synaptonemal complex assembly [GO:0007130]	catalytic complex [GO:1902494]; condensed nuclear chromosome [GO:0000794]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; synaptonemal complex [GO:0000795]		catalytic complex [GO:1902494]; condensed nuclear chromosome [GO:0000794]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; synaptonemal complex [GO:0000795]; bone remodeling [GO:0046849]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; peptidyl-lysine hydroxylation [GO:0017185]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:23959653}.
Q92793	reviewed	CBP_HUMAN	CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)	CREBBP CBP	Homo sapiens (Human)	2442	FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:9707565}.		cellular response to nutrient levels [GO:0031669]; cellular response to UV [GO:0034644]; embryonic digit morphogenesis [GO:0042733]; homeostatic process [GO:0042592]; N-terminal peptidyl-lysine acetylation [GO:0018076]; negative regulation of transcription by RNA polymerase I [GO:0016479]; negative regulation of transcription by RNA polymerase II [GO:0000122]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein acetylation [GO:0006473]; protein destabilization [GO:0031648]; protein-containing complex assembly [GO:0065003]; regulation of cellular response to heat [GO:1900034]; regulation of DNA-templated transcription [GO:0006355]; regulation of smoothened signaling pathway [GO:0008589]; response to hypoxia [GO:0001666]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; MRF binding [GO:0043426]; p53 binding [GO:0002039]; peptide N-acetyltransferase activity [GO:0034212]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; MRF binding [GO:0043426]; p53 binding [GO:0002039]; peptide N-acetyltransferase activity [GO:0034212]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]; cellular response to nutrient levels [GO:0031669]; cellular response to UV [GO:0034644]; embryonic digit morphogenesis [GO:0042733]; homeostatic process [GO:0042592]; N-terminal peptidyl-lysine acetylation [GO:0018076]; negative regulation of transcription by RNA polymerase I [GO:0016479]; negative regulation of transcription by RNA polymerase II [GO:0000122]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein acetylation [GO:0006473]; protein destabilization [GO:0031648]; protein-containing complex assembly [GO:0065003]; regulation of cellular response to heat [GO:1900034]; regulation of DNA-templated transcription [GO:0006355]; regulation of smoothened signaling pathway [GO:0008589]; response to hypoxia [GO:0001666]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12929931}. Nucleus {ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:15488321, ECO:0000269|PubMed:25593309}. Note=Recruited to nuclear bodies by SS18L1/CREST (PubMed:15488321). In the presence of ALX1 relocalizes from the cytoplasm to the nucleus (PubMed:12929931). {ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:15488321}.
Q92794	reviewed	KAT6A_HUMAN	Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220)	KAT6A MOZ MYST3 RUNXBP2 ZNF220	Homo sapiens (Human)	2004	FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}.		cellular senescence [GO:0090398]; chromosome organization [GO:0051276]; myeloid cell differentiation [GO:0030099]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein acetylation [GO:0006473]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of signal transduction by p53 class mediator [GO:1901796]	cytosol [GO:0005829]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; PML body [GO:0016605]	acetyltransferase activity [GO:0016407]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; PML body [GO:0016605]; acetyltransferase activity [GO:0016407]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]; cellular senescence [GO:0090398]; chromosome organization [GO:0051276]; myeloid cell differentiation [GO:0030099]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein acetylation [GO:0006473]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of signal transduction by p53 class mediator [GO:1901796]	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus, PML body. Note=Recruited into PML body after DNA damage.
Q92796	reviewed	DLG3_HUMAN	Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR)	DLG3 KIAA1232	Homo sapiens (Human)	817	FUNCTION: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.		cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; establishment of planar polarity [GO:0001736]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein tyrosine kinase activity [GO:0061098]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]	adherens junction [GO:0005912]; AMPA glutamate receptor complex [GO:0032281]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	kinase binding [GO:0019900]; phosphatase binding [GO:0019902]; ubiquitin protein ligase binding [GO:0031625]	adherens junction [GO:0005912]; AMPA glutamate receptor complex [GO:0032281]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; kinase binding [GO:0019900]; phosphatase binding [GO:0019902]; ubiquitin protein ligase binding [GO:0031625]; cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; establishment of planar polarity [GO:0001736]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein tyrosine kinase activity [GO:0061098]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]	
Q92797	reviewed	SYMPK_HUMAN	Symplekin	SYMPK SPK	Homo sapiens (Human)	1274	FUNCTION: Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}.	MISCELLANEOUS: Could be used as a differentiation marker in the differential diagnosis of tumors.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell adhesion [GO:0007155]; mRNA polyadenylation [GO:0006378]; negative regulation of protein binding [GO:0032091]	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cell adhesion [GO:0007155]; mRNA polyadenylation [GO:0006378]; negative regulation of protein binding [GO:0032091]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Nucleus, nucleoplasm. Note=Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells. Colocalizes with HSF1 in nuclear stress bodies upon heat shock (PubMed:14707147). {ECO:0000269|PubMed:14707147}.
Q92800	reviewed	EZH1_HUMAN	Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)	EZH1 KIAA0388	Homo sapiens (Human)	747	FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}.		anatomical structure morphogenesis [GO:0009653]; chromatin remodeling [GO:0006338]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; subtelomeric heterochromatin formation [GO:0031509]	chromosome, telomeric region [GO:0000781]; ESC/E(Z) complex [GO:0035098]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K27 trimethyltransferase activity [GO:0140951]; transcription corepressor activity [GO:0003714]	chromosome, telomeric region [GO:0000781]; ESC/E(Z) complex [GO:0035098]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K27 trimethyltransferase activity [GO:0140951]; transcription corepressor activity [GO:0003714]; anatomical structure morphogenesis [GO:0009653]; chromatin remodeling [GO:0006338]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; subtelomeric heterochromatin formation [GO:0031509]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19026781}. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.
Q92802	reviewed	N42L2_HUMAN	NEDD4-binding protein 2-like 2 (Phosphonoformate immuno-associated protein 5)	N4BP2L2 CG005 PFAAP5	Homo sapiens (Human)	583			blastocyst development [GO:0001824]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714]; blastocyst development [GO:0001824]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]	
Q92804	reviewed	RBP56_HUMAN	TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56)	TAF15 RBP56 TAF2N	Homo sapiens (Human)	592	FUNCTION: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016}.		mRNA stabilization [GO:0048255]; positive regulation of DNA-templated transcription [GO:0045893]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712]; mRNA stabilization [GO:0048255]; positive regulation of DNA-templated transcription [GO:0045893]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19124016}. Cytoplasm {ECO:0000269|PubMed:19124016}. Note=Shuttles from the nucleus to the cytoplasm.
Q92805	reviewed	GOGA1_HUMAN	Golgin subfamily A member 1 (Golgin-97)	GOLGA1	Homo sapiens (Human)	767	FUNCTION: Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. {ECO:0000269|PubMed:29084197}.	MISCELLANEOUS: Antibodies against GOLGA1 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex. {ECO:0000269|PubMed:9324025}.		acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802]		acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:10209123, ECO:0000269|PubMed:10209125, ECO:0000269|PubMed:9324025}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:29084197}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9CW79}.
Q92813	reviewed	IOD2_HUMAN	Type II iodothyronine deiodinase (EC 1.21.99.4) (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase)	DIO2 ITDI2 TXDI2	Homo sapiens (Human)	273	FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	MISCELLANEOUS: [Isoform 2]: Has a Sec in positions 90, 169 and 302. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Has a Sec in position 37. {ECO:0000305}.	hormone biosynthetic process [GO:0042446]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to lipopolysaccharide [GO:0032496]; selenocysteine incorporation [GO:0001514]; thyroid hormone generation [GO:0006590]; thyroid hormone metabolic process [GO:0042403]	membrane [GO:0016020]; plasma membrane [GO:0005886]	selenium binding [GO:0008430]; thyroxine 5'-deiodinase activity [GO:0004800]; thyroxine 5-deiodinase activity [GO:0033798]; ubiquitin protein ligase binding [GO:0031625]	membrane [GO:0016020]; plasma membrane [GO:0005886]; selenium binding [GO:0008430]; thyroxine 5'-deiodinase activity [GO:0004800]; thyroxine 5-deiodinase activity [GO:0033798]; ubiquitin protein ligase binding [GO:0031625]; hormone biosynthetic process [GO:0042446]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to lipopolysaccharide [GO:0032496]; selenocysteine incorporation [GO:0001514]; thyroid hormone generation [GO:0006590]; thyroid hormone metabolic process [GO:0042403]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q92817	reviewed	EVPL_HUMAN	Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210)	EVPL	Homo sapiens (Human)	2033	FUNCTION: Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.		epidermis development [GO:0008544]; intermediate filament cytoskeleton organization [GO:0045104]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; regulation of antibacterial peptide production [GO:0002786]; wound healing [GO:0042060]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]	cadherin binding [GO:0045296]; structural molecule activity [GO:0005198]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; cadherin binding [GO:0045296]; structural molecule activity [GO:0005198]; epidermis development [GO:0008544]; intermediate filament cytoskeleton organization [GO:0045104]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; regulation of antibacterial peptide production [GO:0002786]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell junction, desmosome. Cornified envelope. Cytoplasm, cytoskeleton. Note=Colocalized with DSP at desmosomes and along intermediate filaments.
Q92819	reviewed	HYAS2_HUMAN	Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2)	HAS2	Homo sapiens (Human)	552	FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (PubMed:20507985, PubMed:32993960, PubMed:23303191, PubMed:21228273) (Probable). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (PubMed:8798477, PubMed:21228273, PubMed:20507985). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity). {ECO:0000250|UniProtKB:P70312, ECO:0000269|PubMed:20507985, ECO:0000269|PubMed:21228273, ECO:0000269|PubMed:23303191, ECO:0000269|PubMed:32993960, ECO:0000269|PubMed:8798477, ECO:0000305|PubMed:22887999, ECO:0000305|PubMed:30394292}.		atrioventricular canal development [GO:0036302]; bone morphogenesis [GO:0060349]; cellular response to fluid shear stress [GO:0071498]; cellular response to interleukin-1 [GO:0071347]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to tumor necrosis factor [GO:0071356]; endocardial cushion to mesenchymal transition [GO:0090500]; estrous cycle [GO:0044849]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; hyaluronan biosynthetic process [GO:0030213]; kidney development [GO:0001822]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of monocyte aggregation [GO:1900625]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of urine volume [GO:0035810]; regulation of extracellular matrix assembly [GO:1901201]; renal water absorption [GO:0070295]; vasculogenesis [GO:0001570]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]	hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802]; atrioventricular canal development [GO:0036302]; bone morphogenesis [GO:0060349]; cellular response to fluid shear stress [GO:0071498]; cellular response to interleukin-1 [GO:0071347]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to tumor necrosis factor [GO:0071356]; endocardial cushion to mesenchymal transition [GO:0090500]; estrous cycle [GO:0044849]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; hyaluronan biosynthetic process [GO:0030213]; kidney development [GO:0001822]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of monocyte aggregation [GO:1900625]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of urine volume [GO:0035810]; regulation of extracellular matrix assembly [GO:1901201]; renal water absorption [GO:0070295]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22887999, ECO:0000269|PubMed:25795779, ECO:0000269|PubMed:30394292, ECO:0000269|PubMed:8798477}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30394292}; Multi-pass membrane protein {ECO:0000255}. Vesicle {ECO:0000269|PubMed:30394292}. Golgi apparatus membrane {ECO:0000269|PubMed:25795779, ECO:0000269|PubMed:30394292}; Multi-pass membrane protein {ECO:0000255}. Lysosome {ECO:0000269|PubMed:30394292}. Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane and either back to endosomes and lysosomes, or out into extracellular vesicles (PubMed:30394292). Post-translational modifications control HAS2 trafficking (PubMed:30394292). {ECO:0000269|PubMed:30394292}.
Q92820	reviewed	GGH_HUMAN	Gamma-glutamyl hydrolase (EC 3.4.19.9) (Conjugase) (GH) (Gamma-Glu-X carboxypeptidase)	GGH	Homo sapiens (Human)	318	FUNCTION: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate (PubMed:11005824, PubMed:8816764). May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. {ECO:0000269|PubMed:11005824, ECO:0000269|PubMed:8816764}.		tetrahydrofolylpolyglutamate metabolic process [GO:0046900]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; melanosome [GO:0042470]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; vacuole [GO:0005773]	exopeptidase activity [GO:0008238]; gamma-glutamyl-peptidase activity [GO:0034722]; omega peptidase activity [GO:0008242]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; melanosome [GO:0042470]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; vacuole [GO:0005773]; exopeptidase activity [GO:0008238]; gamma-glutamyl-peptidase activity [GO:0034722]; omega peptidase activity [GO:0008242]; tetrahydrofolylpolyglutamate metabolic process [GO:0046900]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000305}. Lysosome {ECO:0000269|PubMed:12643545}. Melanosome {ECO:0000269|PubMed:12643545}. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545}.
Q92823	reviewed	NRCAM_HUMAN	Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)	NRCAM KIAA0343	Homo sapiens (Human)	1304	FUNCTION: Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}.		angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; central nervous system development [GO:0007417]; clustering of voltage-gated sodium channels [GO:0045162]; neuron migration [GO:0001764]; neuronal action potential propagation [GO:0019227]; positive regulation of neuron differentiation [GO:0045666]; protein localization [GO:0008104]; regulation of axon extension [GO:0030516]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; retinal ganglion cell axon guidance [GO:0031290]; synapse assembly [GO:0007416]	axon [GO:0030424]; axon initial segment [GO:0043194]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	ankyrin binding [GO:0030506]; cell-cell adhesion mediator activity [GO:0098632]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]	axon [GO:0030424]; axon initial segment [GO:0043194]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; ankyrin binding [GO:0030506]; cell-cell adhesion mediator activity [GO:0098632]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; central nervous system development [GO:0007417]; clustering of voltage-gated sodium channels [GO:0045162]; neuron migration [GO:0001764]; neuronal action potential propagation [GO:0019227]; positive regulation of neuron differentiation [GO:0045666]; protein localization [GO:0008104]; regulation of axon extension [GO:0030516]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; retinal ganglion cell axon guidance [GO:0031290]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q810U4}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q810U4}. Cell projection, axon {ECO:0000250|UniProtKB:Q810U4}. Secreted {ECO:0000250|UniProtKB:Q810U4}. Note=Detected at nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}.
Q92824	reviewed	PCSK5_HUMAN	Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5)	PCSK5 PC5 PC6	Homo sapiens (Human)	1860	FUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. {ECO:0000269|PubMed:19764806, ECO:0000269|PubMed:20555025, ECO:0000269|PubMed:22740495}.		anterior/posterior pattern specification [GO:0009952]; cell-cell signaling [GO:0007267]; cytokine precursor processing [GO:0140447]; embryo implantation [GO:0007566]; embryonic digestive tract development [GO:0048566]; embryonic skeletal system development [GO:0048706]; heart development [GO:0007507]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; plasma lipoprotein particle remodeling [GO:0034369]; protein processing [GO:0016485]; renin secretion into blood stream [GO:0002001]; respiratory tube development [GO:0030323]; signal peptide processing [GO:0006465]; viral life cycle [GO:0019058]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; serine-type endopeptidase activity [GO:0004252]; anterior/posterior pattern specification [GO:0009952]; cell-cell signaling [GO:0007267]; cytokine precursor processing [GO:0140447]; embryo implantation [GO:0007566]; embryonic digestive tract development [GO:0048566]; embryonic skeletal system development [GO:0048706]; heart development [GO:0007507]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; plasma lipoprotein particle remodeling [GO:0034369]; protein processing [GO:0016485]; renin secretion into blood stream [GO:0002001]; respiratory tube development [GO:0030323]; signal peptide processing [GO:0006465]; viral life cycle [GO:0019058]	SUBCELLULAR LOCATION: [Isoform PC6A]: Secreted. Note=Secreted through the regulated secretory pathway. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform PC6B]: Endomembrane system; Single-pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes. {ECO:0000250}.
Q92826	reviewed	HXB13_HUMAN	Homeobox protein Hox-B13	HOXB13	Homo sapiens (Human)	284	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000269|PubMed:28473536}.		angiogenesis [GO:0001525]; epidermis development [GO:0008544]; epithelial cell maturation involved in prostate gland development [GO:0060743]; negative regulation of transcription by RNA polymerase II [GO:0000122]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of growth [GO:0040008]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; response to wounding [GO:0009611]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; angiogenesis [GO:0001525]; epidermis development [GO:0008544]; epithelial cell maturation involved in prostate gland development [GO:0060743]; negative regulation of transcription by RNA polymerase II [GO:0000122]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of growth [GO:0040008]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Nucleus.
Q92830	reviewed	KAT2A_HUMAN	Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97)	KAT2A GCN5 GCN5L2	Homo sapiens (Human)	837	FUNCTION: Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase, succinyltransferase or malonyltransferase, depending on the context (PubMed:29211711, PubMed:35995428). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, PPARGC1A, PLK4 and TBX5 (PubMed:17301242, PubMed:16753578, PubMed:27796307, PubMed:29174768). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Acts as a negative regulator of gluconeogenesis by mediating acetylation and subsequent inactivation of PPARGC1A (PubMed:16753578, PubMed:23142079). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297). {ECO:0000250|UniProtKB:Q9JHD2, ECO:0000269|PubMed:16753578, ECO:0000269|PubMed:17301242, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:29174768, ECO:0000269|PubMed:29211711, ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837, ECO:0000269|PubMed:31542297, ECO:0000269|PubMed:35995428}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. {ECO:0000269|PubMed:11384967}.		cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; chromatin remodeling [GO:0006338]; fibroblast proliferation [GO:0048144]; gluconeogenesis [GO:0006094]; heart development [GO:0007507]; histone succinylation [GO:0106077]; in utero embryonic development [GO:0001701]; internal peptidyl-lysine acetylation [GO:0018393]; intracellular distribution of mitochondria [GO:0048312]; limb development [GO:0060173]; long-term memory [GO:0007616]; metencephalon development [GO:0022037]; midbrain development [GO:0030901]; multicellular organism growth [GO:0035264]; negative regulation of centriole replication [GO:0046600]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; peptidyl-lysine glutarylation [GO:0106227]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell projection organization [GO:0031346]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bone development [GO:1903010]; regulation of cartilage development [GO:0061035]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of protein stability [GO:0031647]; regulation of regulatory T cell differentiation [GO:0045589]; regulation of RNA splicing [GO:0043484]; regulation of stem cell population maintenance [GO:2000036]; regulation of synaptic plasticity [GO:0048167]; regulation of T cell activation [GO:0050863]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; somitogenesis [GO:0001756]; telencephalon development [GO:0021537]	ATAC complex [GO:0140672]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; histone acetyltransferase complex [GO:0000123]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone deacetylase binding [GO:0042826]; histone glutaryltransferase activity [GO:0106229]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone succinyltransferase activity [GO:0106078]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; protein phosphatase binding [GO:0019903]; transcription coactivator activity [GO:0003713]	ATAC complex [GO:0140672]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; histone acetyltransferase complex [GO:0000123]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone deacetylase binding [GO:0042826]; histone glutaryltransferase activity [GO:0106229]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone succinyltransferase activity [GO:0106078]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; protein phosphatase binding [GO:0019903]; transcription coactivator activity [GO:0003713]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; chromatin remodeling [GO:0006338]; fibroblast proliferation [GO:0048144]; gluconeogenesis [GO:0006094]; heart development [GO:0007507]; histone succinylation [GO:0106077]; in utero embryonic development [GO:0001701]; internal peptidyl-lysine acetylation [GO:0018393]; intracellular distribution of mitochondria [GO:0048312]; limb development [GO:0060173]; long-term memory [GO:0007616]; metencephalon development [GO:0022037]; midbrain development [GO:0030901]; multicellular organism growth [GO:0035264]; negative regulation of centriole replication [GO:0046600]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; peptidyl-lysine glutarylation [GO:0106227]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell projection organization [GO:0031346]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bone development [GO:1903010]; regulation of cartilage development [GO:0061035]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of protein stability [GO:0031647]; regulation of regulatory T cell differentiation [GO:0045589]; regulation of RNA splicing [GO:0043484]; regulation of stem cell population maintenance [GO:2000036]; regulation of synaptic plasticity [GO:0048167]; regulation of T cell activation [GO:0050863]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; somitogenesis [GO:0001756]; telencephalon development [GO:0021537]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:29211711}. Chromosome {ECO:0000269|PubMed:29211711}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27796307}. Note=Mainly localizes to the nucleus (PubMed:27796307). Localizes to sites of DNA damage (PubMed:25593309). Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation (PubMed:27796307). {ECO:0000269|PubMed:27796307}.
Q92831	reviewed	KAT2B_HUMAN	Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)	KAT2B PCAF	Homo sapiens (Human)	832	FUNCTION: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (PubMed:8945521). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (PubMed:8945521). Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5 (PubMed:9707565, PubMed:10675335, PubMed:23001180, PubMed:27796307, PubMed:23932781, PubMed:26867678, PubMed:29174768). Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A (PubMed:8684459). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing (PubMed:26867678). Acetylates MAPRE1/EB1, promoting dynamic kinetochore-microtubule interactions in early mitosis (PubMed:23001180). Also acetylates spermidine (PubMed:27389534). {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:26867678, ECO:0000269|PubMed:27389534, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:29174768, ECO:0000269|PubMed:8684459, ECO:0000269|PubMed:8945521, ECO:0000269|PubMed:9707565}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. {ECO:0000269|PubMed:12486002}.		cell cycle [GO:0007049]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; cellular response to parathyroid hormone stimulus [GO:0071374]; chromatin remodeling [GO:0006338]; gluconeogenesis [GO:0006094]; heart development [GO:0007507]; internal peptidyl-lysine acetylation [GO:0018393]; limb development [GO:0060173]; memory [GO:0007613]; N-terminal peptidyl-lysine acetylation [GO:0018076]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of centriole replication [GO:0046600]; negative regulation of rRNA processing [GO:2000233]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of glycolytic process [GO:0045821]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; protein acetylation [GO:0006473]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of protein ADP-ribosylation [GO:0010835]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; rhythmic process [GO:0048511]; transcription initiation-coupled chromatin remodeling [GO:0045815]; vasodilation [GO:0042311]	A band [GO:0031672]; actomyosin [GO:0042641]; ATAC complex [GO:0140672]; centrosome [GO:0005813]; cytosol [GO:0005829]; I band [GO:0031674]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SAGA complex [GO:0000124]	acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; diamine N-acetyltransferase activity [GO:0004145]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K9 acetyltransferase activity [GO:0043992]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; protein kinase binding [GO:0019901]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	A band [GO:0031672]; actomyosin [GO:0042641]; ATAC complex [GO:0140672]; centrosome [GO:0005813]; cytosol [GO:0005829]; I band [GO:0031674]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SAGA complex [GO:0000124]; acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; diamine N-acetyltransferase activity [GO:0004145]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K9 acetyltransferase activity [GO:0043992]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; protein kinase binding [GO:0019901]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; cell cycle [GO:0007049]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; cellular response to parathyroid hormone stimulus [GO:0071374]; chromatin remodeling [GO:0006338]; gluconeogenesis [GO:0006094]; heart development [GO:0007507]; internal peptidyl-lysine acetylation [GO:0018393]; limb development [GO:0060173]; memory [GO:0007613]; N-terminal peptidyl-lysine acetylation [GO:0018076]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of centriole replication [GO:0046600]; negative regulation of rRNA processing [GO:2000233]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of glycolytic process [GO:0045821]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; protein acetylation [GO:0006473]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of protein ADP-ribosylation [GO:0010835]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; rhythmic process [GO:0048511]; transcription initiation-coupled chromatin remodeling [GO:0045815]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20940255, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:29174768}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29174768}. Cytoplasm {ECO:0000269|PubMed:20940255}. Note=Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation. Subcellular location may vary depending upon cell differentiation state. Cytoplasmic at the very stages of keratinocyte differentiation, becomes nuclear at later differentiation stages. Cytoplasmic in basal epithelial cells (undifferentiated cells) and nuclear in parabasal cells (differentiated cells) (PubMed:20940255). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000269|PubMed:20940255, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:29174768}.
Q92832	reviewed	NELL1_HUMAN	Protein kinase C-binding protein NELL1 (NEL-like protein 1) (Nel-related protein 1)	NELL1 NRP1	Homo sapiens (Human)	810	FUNCTION: Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. {ECO:0000269|PubMed:21723284}.		cell differentiation [GO:0030154]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of protein catabolic process [GO:0042177]; nervous system development [GO:0007399]; positive regulation of bone mineralization [GO:0030501]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of gene expression [GO:0010468]; regulation of osteoblast differentiation [GO:0045667]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]	calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; protein kinase C binding [GO:0005080]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; protein kinase C binding [GO:0005080]; cell differentiation [GO:0030154]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of protein catabolic process [GO:0042177]; nervous system development [GO:0007399]; positive regulation of bone mineralization [GO:0030501]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of gene expression [GO:0010468]; regulation of osteoblast differentiation [GO:0045667]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21723284}. Nucleus envelope {ECO:0000269|PubMed:21723284}. Secreted {ECO:0000250}. Note=Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.
Q92833	reviewed	JARD2_HUMAN	Protein Jumonji (Jumonji/ARID domain-containing protein 2)	JARID2 JMJ	Homo sapiens (Human)	1246	FUNCTION: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). {ECO:0000250|UniProtKB:Q62315, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.		cardiac muscle cell proliferation [GO:0060038]; cellular response to leukemia inhibitory factor [GO:1990830]; central nervous system development [GO:0007417]; chromatin remodeling [GO:0006338]; dosage compensation by inactivation of X chromosome [GO:0009048]; facultative heterochromatin formation [GO:0140718]; liver development [GO:0001889]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein localization to pericentric heterochromatin [GO:1902682]; regulation of gene expression [GO:0010468]; spleen development [GO:0048536]; stem cell differentiation [GO:0048863]; thymus development [GO:0048538]	chromatin [GO:0000785]; ESC/E(Z) complex [GO:0035098]; histone methyltransferase complex [GO:0035097]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K27 methyltransferase activity [GO:0046976]; ubiquitin binding [GO:0043130]; ubiquitin modification-dependent histone binding [GO:0061649]	chromatin [GO:0000785]; ESC/E(Z) complex [GO:0035098]; histone methyltransferase complex [GO:0035097]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K27 methyltransferase activity [GO:0046976]; ubiquitin binding [GO:0043130]; ubiquitin modification-dependent histone binding [GO:0061649]; cardiac muscle cell proliferation [GO:0060038]; cellular response to leukemia inhibitory factor [GO:1990830]; central nervous system development [GO:0007417]; chromatin remodeling [GO:0006338]; dosage compensation by inactivation of X chromosome [GO:0009048]; facultative heterochromatin formation [GO:0140718]; liver development [GO:0001889]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein localization to pericentric heterochromatin [GO:1902682]; regulation of gene expression [GO:0010468]; spleen development [GO:0048536]; stem cell differentiation [GO:0048863]; thymus development [GO:0048538]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:29499137}. Note=Colocalizes with the PRC2 complex on chromatin. {ECO:0000269|PubMed:29499137}.
Q92834	reviewed	RPGR_HUMAN	X-linked retinitis pigmentosa GTPase regulator	RPGR RP3 XLRP3	Homo sapiens (Human)	1020	FUNCTION: Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia. {ECO:0000250, ECO:0000269|PubMed:21933838}.		cilium assembly [GO:0060271]; intracellular protein transport [GO:0006886]; intraciliary transport [GO:0042073]; protein ubiquitination [GO:0016567]; response to stimulus [GO:0050896]; ubiquitin-dependent protein catabolic process [GO:0006511]; visual perception [GO:0007601]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; photoreceptor outer segment [GO:0001750]; sperm flagellum [GO:0036126]	guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; photoreceptor outer segment [GO:0001750]; sperm flagellum [GO:0036126]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; cilium assembly [GO:0060271]; intracellular protein transport [GO:0006886]; intraciliary transport [GO:0042073]; protein ubiquitination [GO:0016567]; response to stimulus [GO:0050896]; ubiquitin-dependent protein catabolic process [GO:0006511]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9R0X5}. Golgi apparatus {ECO:0000269|PubMed:15772089}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9R0X5}. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium (By similarity). Colocalizes with WHRN in the photoreceptor connecting cilium (By similarity). Colocalizes with CEP290 in the photoreceptor connecting cilium (By similarity). Colocalizes with RPGRIP1 in the photoreceptor connecting cilium (By similarity). {ECO:0000250|UniProtKB:Q9R0X5}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme.
Q92835	reviewed	SHIP1_HUMAN	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)	INPP5D SHIP SHIP1	Homo sapiens (Human)	1189	FUNCTION: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:8723348, PubMed:10764818, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:9108392, PubMed:10764818, PubMed:8769125). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}.		apoptotic process [GO:0006915]; determination of adult lifespan [GO:0008340]; immunoglobulin mediated immune response [GO:0016064]; intracellular signal transduction [GO:0035556]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of bone resorption [GO:0045779]; negative regulation of immune response [GO:0050777]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of neutrophil differentiation [GO:0045659]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of signal transduction [GO:0009968]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of immune response [GO:0050776]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; SH3 domain binding [GO:0017124]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; SH3 domain binding [GO:0017124]; apoptotic process [GO:0006915]; determination of adult lifespan [GO:0008340]; immunoglobulin mediated immune response [GO:0016064]; intracellular signal transduction [GO:0035556]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of bone resorption [GO:0045779]; negative regulation of immune response [GO:0050777]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of neutrophil differentiation [GO:0045659]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of signal transduction [GO:0009968]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of immune response [GO:0050776]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10822173}. Cell membrane {ECO:0000250|UniProtKB:Q9ES52}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9ES52}. Membrane raft {ECO:0000250|UniProtKB:Q9ES52}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9ES52}. Membrane {ECO:0000269|PubMed:10822173}; Peripheral membrane protein {ECO:0000269|PubMed:10822173}. Note=Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Translocates from the cytoplasm to membrane ruffles in a FCGR3/CD16-dependent manner. Colocalizes with FC-gamma-RIIB receptor (FCGR2B) or FCGR3/CD16 at membrane ruffles. Tyrosine phosphorylation may also participate in membrane localization. {ECO:0000250|UniProtKB:Q9ES52}.
Q92837	reviewed	FRAT1_HUMAN	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas 1) (FRAT-1)	FRAT1	Homo sapiens (Human)	279	FUNCTION: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. {ECO:0000269|PubMed:12556519}.		beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of protein export from nucleus [GO:0046825]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]	molecular function inhibitor activity [GO:0140678]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; molecular function inhibitor activity [GO:0140678]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of protein export from nucleus [GO:0046825]	SUBCELLULAR LOCATION: Cytoplasm.
Q92838	reviewed	EDA_HUMAN	Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form]	EDA ED1 EDA2	Homo sapiens (Human)	391	FUNCTION: Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R (PubMed:8696334, PubMed:11039935, PubMed:27144394, PubMed:34582123). May also play a role in cell adhesion (By similarity). {ECO:0000250|UniProtKB:O54693, ECO:0000269|PubMed:11039935, ECO:0000269|PubMed:27144394, ECO:0000269|PubMed:34582123, ECO:0000269|PubMed:8696334}.; FUNCTION: [Isoform 1]: Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R. {ECO:0000269|PubMed:11039935, ECO:0000269|PubMed:27144394}.; FUNCTION: [Isoform 3]: Binds only to the receptor EDA2R. {ECO:0000269|PubMed:11039935, ECO:0000269|PubMed:27144394}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	animal organ development [GO:0048513]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; cell-matrix adhesion [GO:0007160]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; hair follicle placode formation [GO:0060789]; immune response [GO:0006955]; odontogenesis of dentin-containing tooth [GO:0042475]; pigmentation [GO:0043473]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; salivary gland cavitation [GO:0060662]; trachea gland development [GO:0061153]	apical part of cell [GO:0045177]; collagen trimer [GO:0005581]; cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886]	death receptor agonist activity [GO:0038177]; death receptor binding [GO:0005123]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]	apical part of cell [GO:0045177]; collagen trimer [GO:0005581]; cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886]; death receptor agonist activity [GO:0038177]; death receptor binding [GO:0005123]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; animal organ development [GO:0048513]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; cell-matrix adhesion [GO:0007160]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; hair follicle placode formation [GO:0060789]; immune response [GO:0006955]; odontogenesis of dentin-containing tooth [GO:0042475]; pigmentation [GO:0043473]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; salivary gland cavitation [GO:0060662]; trachea gland development [GO:0061153]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O54693}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O54693}.; SUBCELLULAR LOCATION: [Ectodysplasin-A, secreted form]: Secreted {ECO:0000269|PubMed:11309369, ECO:0000269|PubMed:34582123}.
Q92839	reviewed	HYAS1_HUMAN	Hyaluronan synthase 1 (EC 2.4.1.212) (Hyaluronate synthase 1) (Hyaluronic acid synthase 1) (HA synthase 1) (HuHAS1)	HAS1 HAS	Homo sapiens (Human)	578	FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; glycosaminoglycan biosynthetic process [GO:0006024]; hyaluronan biosynthetic process [GO:0030213]; negative regulation of fibroblast migration [GO:0010764]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802]; cell adhesion [GO:0007155]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; glycosaminoglycan biosynthetic process [GO:0006024]; hyaluronan biosynthetic process [GO:0030213]; negative regulation of fibroblast migration [GO:0010764]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q92841	reviewed	DDX17_HUMAN	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72)	DDX17	Homo sapiens (Human)	729	FUNCTION: As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). {ECO:0000250|UniProtKB:Q501J6, ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17485482, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:18334637, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:20406972, ECO:0000269|PubMed:20663877, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:23022728, ECO:0000269|PubMed:24275493, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:24910439, ECO:0000269|PubMed:25126784, ECO:0000269|PubMed:26209609, ECO:0000269|PubMed:27478153, ECO:0000305}.	MISCELLANEOUS: [Isoform 1]: Starts at an alternative CUG codon.; MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at Met-80 of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 2. {ECO:0000305}.	alternative mRNA splicing, via spliceosome [GO:0000380]; androgen receptor signaling pathway [GO:0030521]; defense response to virus [GO:0051607]; epithelial to mesenchymal transition [GO:0001837]; immune system process [GO:0002376]; intracellular estrogen receptor signaling pathway [GO:0030520]; miRNA metabolic process [GO:0010586]; myoblast differentiation [GO:0045445]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coactivator activity [GO:0003713]; alternative mRNA splicing, via spliceosome [GO:0000380]; androgen receptor signaling pathway [GO:0030521]; defense response to virus [GO:0051607]; epithelial to mesenchymal transition [GO:0001837]; immune system process [GO:0002376]; intracellular estrogen receptor signaling pathway [GO:0030520]; miRNA metabolic process [GO:0010586]; myoblast differentiation [GO:0045445]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:12595555, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:25126784}. Nucleus, nucleolus {ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:22002106}. Cytoplasm, cytosol {ECO:0000269|PubMed:25126784}. Note=In the course of bunyavirus infection, relocalizes from the nucleus to the cytosol where it binds viral RNA to antagonize replication. {ECO:0000269|PubMed:25126784}.
Q92843	reviewed	B2CL2_HUMAN	Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W)	BCL2L2 BCLW KIAA0271	Homo sapiens (Human)	193	FUNCTION: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. {ECO:0000269|PubMed:8761287}.	MISCELLANEOUS: [Isoform 3]: Based on a readthrough transcript which may produce a BCL2L2-PABPN1 fusion protein. {ECO:0000305}.	cellular response to amyloid-beta [GO:1904646]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glycine [GO:1905430]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of mitochondrial membrane permeability [GO:0035795]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; regulation of apoptotic process [GO:0042981]; response to ischemia [GO:0002931]; Sertoli cell proliferation [GO:0060011]; spermatogenesis [GO:0007283]	Bcl-2 family protein complex [GO:0097136]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]	BH domain binding [GO:0051400]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	Bcl-2 family protein complex [GO:0097136]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; BH domain binding [GO:0051400]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; cellular response to amyloid-beta [GO:1904646]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glycine [GO:1905430]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of mitochondrial membrane permeability [GO:0035795]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; regulation of apoptotic process [GO:0042981]; response to ischemia [GO:0002931]; Sertoli cell proliferation [GO:0060011]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:11423909, ECO:0000269|PubMed:12952938}; Peripheral membrane protein {ECO:0000269|PubMed:11423909, ECO:0000269|PubMed:12952938}. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
Q92844	reviewed	TANK_HUMAN	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)	TANK ITRAF TRAF2	Homo sapiens (Human)	425	FUNCTION: Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}.		canonical NF-kappaB signal transduction [GO:0007249]; cellular response to interleukin-1 [GO:0071347]; cellular response to ionizing radiation [GO:0071479]; cellular response to tumor necrosis factor [GO:0071356]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of type I interferon production [GO:0032481]; positive regulation of ubiquitin-specific protease activity [GO:2000158]; signal transduction [GO:0007165]; type I interferon-mediated signaling pathway [GO:0060337]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; serine/threonine protein kinase complex [GO:1902554]	deubiquitinase activator activity [GO:0035800]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; serine/threonine protein kinase complex [GO:1902554]; deubiquitinase activator activity [GO:0035800]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; ubiquitin protein ligase binding [GO:0031625]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to interleukin-1 [GO:0071347]; cellular response to ionizing radiation [GO:0071479]; cellular response to tumor necrosis factor [GO:0071356]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of type I interferon production [GO:0032481]; positive regulation of ubiquitin-specific protease activity [GO:2000158]; signal transduction [GO:0007165]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm.
Q92845	reviewed	KIFA3_HUMAN	Kinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein)	KIFAP3 KIF3AP SMAP	Homo sapiens (Human)	792	FUNCTION: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). {ECO:0000250}.		cardiac muscle cell apoptotic process [GO:0010659]; cilium organization [GO:0044782]; microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of thymocyte apoptotic process [GO:0070244]; neuroblast proliferation [GO:0007405]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of calcium-dependent cell-cell adhesion [GO:0046587]; protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]; signal transduction [GO:0007165]; thymocyte apoptotic process [GO:0070242]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; kinesin II complex [GO:0016939]; microtubule cytoskeleton [GO:0015630]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	intraciliary transport particle B binding [GO:0120170]; kinesin binding [GO:0019894]; protein phosphatase binding [GO:0019903]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; kinesin II complex [GO:0016939]; microtubule cytoskeleton [GO:0015630]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; intraciliary transport particle B binding [GO:0120170]; kinesin binding [GO:0019894]; protein phosphatase binding [GO:0019903]; cardiac muscle cell apoptotic process [GO:0010659]; cilium organization [GO:0044782]; microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of thymocyte apoptotic process [GO:0070244]; neuroblast proliferation [GO:0007405]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of calcium-dependent cell-cell adhesion [GO:0046587]; protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]; signal transduction [GO:0007165]; thymocyte apoptotic process [GO:0070242]	
Q92847	reviewed	GHSR_HUMAN	Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)	GHSR	Homo sapiens (Human)	366	FUNCTION: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). {ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:11322507}.		actin polymerization or depolymerization [GO:0008154]; adult feeding behavior [GO:0008343]; cellular response to insulin stimulus [GO:0032869]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to thyroid hormone stimulus [GO:0097067]; decidualization [GO:0046697]; G protein-coupled receptor signaling pathway [GO:0007186]; ghrelin secretion [GO:0036321]; growth hormone secretion [GO:0030252]; hormone-mediated signaling pathway [GO:0009755]; insulin-like growth factor receptor signaling pathway [GO:0048009]; learning or memory [GO:0007611]; negative regulation of appetite [GO:0032099]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin secretion [GO:0046676]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of norepinephrine secretion [GO:0010700]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of appetite [GO:0032100]; positive regulation of eating behavior [GO:1904000]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of small intestinal transit [GO:0120058]; positive regulation of small intestine smooth muscle contraction [GO:1904349]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of gastric motility [GO:1905333]; regulation of growth hormone secretion [GO:0060123]; regulation of hindgut contraction [GO:0043134]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of postsynapse organization [GO:0099175]; regulation of synapse assembly [GO:0051963]; regulation of transmission of nerve impulse [GO:0051969]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to follicle-stimulating hormone [GO:0032354]; response to food [GO:0032094]; response to growth hormone [GO:0060416]; response to hormone [GO:0009725]; response to L-glutamate [GO:1902065]; spermatogenesis [GO:0007283]	cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]	G protein-coupled receptor activity [GO:0004930]; growth hormone secretagogue receptor activity [GO:0001616]; growth hormone-releasing hormone receptor activity [GO:0016520]; identical protein binding [GO:0042802]; peptide hormone binding [GO:0017046]	cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]; G protein-coupled receptor activity [GO:0004930]; growth hormone secretagogue receptor activity [GO:0001616]; growth hormone-releasing hormone receptor activity [GO:0016520]; identical protein binding [GO:0042802]; peptide hormone binding [GO:0017046]; actin polymerization or depolymerization [GO:0008154]; adult feeding behavior [GO:0008343]; cellular response to insulin stimulus [GO:0032869]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to thyroid hormone stimulus [GO:0097067]; decidualization [GO:0046697]; G protein-coupled receptor signaling pathway [GO:0007186]; ghrelin secretion [GO:0036321]; growth hormone secretion [GO:0030252]; hormone-mediated signaling pathway [GO:0009755]; insulin-like growth factor receptor signaling pathway [GO:0048009]; learning or memory [GO:0007611]; negative regulation of appetite [GO:0032099]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin secretion [GO:0046676]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of norepinephrine secretion [GO:0010700]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of appetite [GO:0032100]; positive regulation of eating behavior [GO:1904000]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of small intestinal transit [GO:0120058]; positive regulation of small intestine smooth muscle contraction [GO:1904349]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of gastric motility [GO:1905333]; regulation of growth hormone secretion [GO:0060123]; regulation of hindgut contraction [GO:0043134]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of postsynapse organization [GO:0099175]; regulation of synapse assembly [GO:0051963]; regulation of transmission of nerve impulse [GO:0051969]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to follicle-stimulating hormone [GO:0032354]; response to food [GO:0032094]; response to growth hormone [GO:0060416]; response to hormone [GO:0009725]; response to L-glutamate [GO:1902065]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q92851	reviewed	CASPA_HUMAN	Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]	CASP10 MCH4	Homo sapiens (Human)	521	FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445, ECO:0000269|PubMed:16916640}.; FUNCTION: Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. {ECO:0000269|PubMed:17822854}.; FUNCTION: Isoform C is proteolytically inactive. {ECO:0000269|PubMed:11717445}.	MISCELLANEOUS: [Isoform B]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	CD95 death-inducing signaling complex [GO:0031265]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ripoptosome [GO:0097342]	cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; death effector domain binding [GO:0035877]; ubiquitin protein ligase binding [GO:0031625]	CD95 death-inducing signaling complex [GO:0031265]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ripoptosome [GO:0097342]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; death effector domain binding [GO:0035877]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	
Q92854	reviewed	SEM4D_HUMAN	Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100)	SEMA4D C9orf164 CD100 SEMAJ	Homo sapiens (Human)	862	FUNCTION: Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}.		axon guidance [GO:0007411]; cell adhesion [GO:0007155]; immune response [GO:0006955]; leukocyte aggregation [GO:0070486]; negative chemotaxis [GO:0050919]; negative regulation of alkaline phosphatase activity [GO:0010693]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; ossification involved in bone maturation [GO:0043931]; positive regulation of cell migration [GO:0030335]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of GTPase activity [GO:0043547]; positive regulation of inhibitory synapse assembly [GO:1905704]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360]; regulation of dendrite morphogenesis [GO:0048814]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [GO:1900220]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	chemorepellent activity [GO:0045499]; identical protein binding [GO:0042802]; semaphorin receptor binding [GO:0030215]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; chemorepellent activity [GO:0045499]; identical protein binding [GO:0042802]; semaphorin receptor binding [GO:0030215]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; immune response [GO:0006955]; leukocyte aggregation [GO:0070486]; negative chemotaxis [GO:0050919]; negative regulation of alkaline phosphatase activity [GO:0010693]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; ossification involved in bone maturation [GO:0043931]; positive regulation of cell migration [GO:0030335]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of GTPase activity [GO:0043547]; positive regulation of inhibitory synapse assembly [GO:1905704]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360]; regulation of dendrite morphogenesis [GO:0048814]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [GO:1900220]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}; Single-pass type I membrane protein {ECO:0000255}.
Q92858	reviewed	ATOH1_HUMAN	Transcription factor ATOH1 (Atonal bHLH transcription factor 1) (Class A basic helix-loop-helix protein 14) (bHLHa14) (Helix-loop-helix protein hATH-1) (hATH1) (Protein atonal homolog 1)	ATOH1 ATH1 BHLHA14	Homo sapiens (Human)	354	FUNCTION: Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). {ECO:0000250|UniProtKB:P48985}.		auditory receptor cell fate determination [GO:0042668]; auditory receptor cell fate specification [GO:0042667]; axon development [GO:0061564]; axon guidance [GO:0007411]; central nervous system development [GO:0007417]; cerebral cortex development [GO:0021987]; epithelial cell apoptotic process [GO:1904019]; inner ear morphogenesis [GO:0042472]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of gliogenesis [GO:0014014]; neuroblast migration [GO:0097402]; neuron fate commitment [GO:0048663]; neuron migration [GO:0001764]; Notch signaling pathway [GO:0007219]; positive regulation of inner ear auditory receptor cell differentiation [GO:0045609]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]; auditory receptor cell fate determination [GO:0042668]; auditory receptor cell fate specification [GO:0042667]; axon development [GO:0061564]; axon guidance [GO:0007411]; central nervous system development [GO:0007417]; cerebral cortex development [GO:0021987]; epithelial cell apoptotic process [GO:1904019]; inner ear morphogenesis [GO:0042472]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of gliogenesis [GO:0014014]; neuroblast migration [GO:0097402]; neuron fate commitment [GO:0048663]; neuron migration [GO:0001764]; Notch signaling pathway [GO:0007219]; positive regulation of inner ear auditory receptor cell differentiation [GO:0045609]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q92859	reviewed	NEO1_HUMAN	Neogenin (Immunoglobulin superfamily DCC subclass member 2)	NEO1 IGDCC2 NGN	Homo sapiens (Human)	1461	FUNCTION: Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}.	MISCELLANEOUS: Knockdown of NEO1 in C2C12 cells results in the enhancement of the BMP-2-induced processes of osteoblastic differentiation and phosphorylation of Smad1, Smad5, and Smad8. Conversely, overexpression suppresses these processes.	axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; myoblast fusion [GO:0007520]; negative regulation of axon regeneration [GO:0048681]; negative regulation of protein secretion [GO:0050709]; neuron migration [GO:0001764]; positive regulation of BMP signaling pathway [GO:0030513]; protein secretion [GO:0009306]; regulation of DNA-templated transcription [GO:0006355]	axonal growth cone [GO:0044295]; cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]	BMP receptor binding [GO:0070700]; cadherin binding [GO:0045296]; co-receptor binding [GO:0039706]; signaling receptor activity [GO:0038023]	axonal growth cone [GO:0044295]; cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; BMP receptor binding [GO:0070700]; cadherin binding [GO:0045296]; co-receptor binding [GO:0039706]; signaling receptor activity [GO:0038023]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; myoblast fusion [GO:0007520]; negative regulation of axon regeneration [GO:0048681]; negative regulation of protein secretion [GO:0050709]; neuron migration [GO:0001764]; positive regulation of BMP signaling pathway [GO:0030513]; protein secretion [GO:0009306]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q92870	reviewed	APBB2_HUMAN	Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1)	APBB2 FE65L FE65L1	Homo sapiens (Human)	758	FUNCTION: Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}.		intracellular signal transduction [GO:0035556]; maintenance of lens transparency [GO:0036438]; negative regulation of cell cycle phase transition [GO:1901988]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; smooth muscle contraction [GO:0006939]; synapse organization [GO:0050808]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleus [GO:0005634]; synapse [GO:0045202]	amyloid-beta binding [GO:0001540]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleus [GO:0005634]; synapse [GO:0045202]; amyloid-beta binding [GO:0001540]; intracellular signal transduction [GO:0035556]; maintenance of lens transparency [GO:0036438]; negative regulation of cell cycle phase transition [GO:1901988]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; smooth muscle contraction [GO:0006939]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:14527950}. Golgi apparatus {ECO:0000269|PubMed:14527950}. Early endosome {ECO:0000269|PubMed:14527950}.
Q92871	reviewed	PMM1_HUMAN	Phosphomannomutase 1 (PMM 1) (EC 5.4.2.8) (PMMH-22)	PMM1 PMMH22	Homo sapiens (Human)	262	FUNCTION: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269|PubMed:16540464}.		cellular response to leukemia inhibitory factor [GO:1990830]; GDP-mannose biosynthetic process [GO:0009298]; mannose metabolic process [GO:0006013]; protein N-linked glycosylation [GO:0006487]	cytosol [GO:0005829]; neuronal cell body [GO:0043025]	metal ion binding [GO:0046872]; phosphomannomutase activity [GO:0004615]	cytosol [GO:0005829]; neuronal cell body [GO:0043025]; metal ion binding [GO:0046872]; phosphomannomutase activity [GO:0004615]; cellular response to leukemia inhibitory factor [GO:1990830]; GDP-mannose biosynthetic process [GO:0009298]; mannose metabolic process [GO:0006013]; protein N-linked glycosylation [GO:0006487]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O35621}.
Q92874	reviewed	DNSL2_HUMAN	Deoxyribonuclease-1-like 2 (EC 3.1.21.-) (DNase I homolog protein DHP1) (Deoxyribonuclease I-like 2) (DNase I-like 2)	DNASE1L2 DHP1 DNAS1L2	Homo sapiens (Human)	299	FUNCTION: Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells. {ECO:0000269|PubMed:16902420}.	MISCELLANEOUS: [Isoform 2]: Specifically expressed in peripheral blood leukocytes. {ECO:0000305}.	corneocyte development [GO:0003335]; DNA catabolic process [GO:0006308]; DNA metabolic process [GO:0006259]; hair follicle development [GO:0001942]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]; DNA nuclease activity [GO:0004536]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]; DNA nuclease activity [GO:0004536]; corneocyte development [GO:0003335]; DNA catabolic process [GO:0006308]; DNA metabolic process [GO:0006259]; hair follicle development [GO:0001942]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16902420}. Secreted {ECO:0000305}.
Q92876	reviewed	KLK6_HUMAN	Kallikrein-6 (EC 3.4.21.-) (Neurosin) (Protease M) (SP59) (Serine protease 18) (Serine protease 9) (Zyme)	KLK6 PRSS18 PRSS9	Homo sapiens (Human)	244	FUNCTION: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. {ECO:0000269|PubMed:11983703, ECO:0000269|PubMed:12878203, ECO:0000269|PubMed:12928483, ECO:0000269|PubMed:15557757, ECO:0000269|PubMed:16321973, ECO:0000269|PubMed:16987227}.		amyloid precursor protein metabolic process [GO:0042982]; central nervous system development [GO:0007417]; collagen catabolic process [GO:0030574]; hormone metabolic process [GO:0042445]; myelination [GO:0042552]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; protein autoprocessing [GO:0016540]; regulation of cell differentiation [GO:0045595]; regulation of neuron projection development [GO:0010975]; response to wounding [GO:0009611]; tissue regeneration [GO:0042246]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intercellular bridge [GO:0045171]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; secretory granule [GO:0030141]	serine-type endopeptidase activity [GO:0004252]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intercellular bridge [GO:0045171]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]; amyloid precursor protein metabolic process [GO:0042982]; central nervous system development [GO:0007417]; collagen catabolic process [GO:0030574]; hormone metabolic process [GO:0042445]; myelination [GO:0042552]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; protein autoprocessing [GO:0016540]; regulation of cell differentiation [GO:0045595]; regulation of neuron projection development [GO:0010975]; response to wounding [GO:0009611]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
Q92878	reviewed	RAD50_HUMAN	DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)	RAD50	Homo sapiens (Human)	1312	FUNCTION: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.	MISCELLANEOUS: In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells.	chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; homologous recombination [GO:0035825]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of telomere capping [GO:1904354]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; reciprocal meiotic recombination [GO:0007131]; regulation of mitotic recombination [GO:0000019]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomerase [GO:0007004]; telomeric 3' overhang formation [GO:0031860]	BRCA1-C complex [GO:0070533]; chromosomal region [GO:0098687]; chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; membrane [GO:0016020]; Mre11 complex [GO:0030870]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; double-stranded telomeric DNA binding [GO:0003691]; G-quadruplex DNA binding [GO:0051880]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; single-stranded telomeric DNA binding [GO:0043047]	BRCA1-C complex [GO:0070533]; chromosomal region [GO:0098687]; chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; membrane [GO:0016020]; Mre11 complex [GO:0030870]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; double-stranded telomeric DNA binding [GO:0003691]; G-quadruplex DNA binding [GO:0051880]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; single-stranded telomeric DNA binding [GO:0043047]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; homologous recombination [GO:0035825]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of telomere capping [GO:1904354]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; reciprocal meiotic recombination [GO:0007131]; regulation of mitotic recombination [GO:0000019]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomerase [GO:0007004]; telomeric 3' overhang formation [GO:0031860]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10783165, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:26215093}. Chromosome, telomere {ECO:0000269|PubMed:10888888}. Chromosome {ECO:0000269|PubMed:26215093}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000269|PubMed:10783165, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:26215093}.
Q92879	reviewed	CELF1_HUMAN	CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2)	CELF1 BRUNOL2 CUGBP CUGBP1 NAB50	Homo sapiens (Human)	486	FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250, ECO:0000269|PubMed:10536163, ECO:0000269|PubMed:11124939, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:12799066, ECO:0000269|PubMed:14726956, ECO:0000269|PubMed:16601207, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:28431233}.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.	embryo development ending in birth or egg hatching [GO:0009792]; germ cell development [GO:0007281]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; post-transcriptional gene silencing [GO:0016441]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of inflammatory response [GO:0050727]; regulation of RNA splicing [GO:0043484]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinucleolar compartment [GO:0097356]; ribonucleoprotein complex [GO:1990904]	BRE binding [GO:0042835]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinucleolar compartment [GO:0097356]; ribonucleoprotein complex [GO:1990904]; BRE binding [GO:0042835]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; embryo development ending in birth or egg hatching [GO:0009792]; germ cell development [GO:0007281]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; post-transcriptional gene silencing [GO:0016441]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of inflammatory response [GO:0050727]; regulation of RNA splicing [GO:0043484]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8948631}. Cytoplasm {ECO:0000269|PubMed:8948631}. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments.
Q92882	reviewed	OSTF1_HUMAN	Osteoclast-stimulating factor 1	OSTF1	Homo sapiens (Human)	214	FUNCTION: Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity. {ECO:0000269|PubMed:10092216}.		ossification [GO:0001503]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]	SH3 domain binding [GO:0017124]	extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; SH3 domain binding [GO:0017124]; ossification [GO:0001503]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q92886	reviewed	NGN1_HUMAN	Neurogenin-1 (NGN-1) (Class A basic helix-loop-helix protein 6) (bHLHa6) (Neurogenic basic-helix-loop-helix protein) (Neurogenic differentiation factor 3) (NeuroD3)	NEUROG1 BHLHA6 NEUROD3 NGN NGN1	Homo sapiens (Human)	237	FUNCTION: Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). {ECO:0000250}.		auditory behavior [GO:0031223]; axon development [GO:0061564]; cell fate commitment [GO:0045165]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; craniofacial suture morphogenesis [GO:0097094]; exit from mitosis [GO:0010458]; forebrain development [GO:0030900]; genitalia development [GO:0048806]; genitalia morphogenesis [GO:0035112]; hard palate morphogenesis [GO:1905748]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; learned vocalization behavior [GO:0098583]; mastication [GO:0071626]; negative regulation of relaxation of muscle [GO:1901078]; negative regulation of saliva secretion [GO:1905747]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; peristalsis [GO:0030432]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of muscle organ development [GO:0048634]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory organ development [GO:0007423]; thorax and anterior abdomen determination [GO:0007356]; trigeminal nerve development [GO:0021559]; vestibulocochlear nerve formation [GO:0021650]	chromatin [GO:0000785]; nucleus [GO:0005634]; perikaryon [GO:0043204]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein homodimerization activity [GO:0042803]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; perikaryon [GO:0043204]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein homodimerization activity [GO:0042803]; sequence-specific double-stranded DNA binding [GO:1990837]; auditory behavior [GO:0031223]; axon development [GO:0061564]; cell fate commitment [GO:0045165]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; craniofacial suture morphogenesis [GO:0097094]; exit from mitosis [GO:0010458]; forebrain development [GO:0030900]; genitalia development [GO:0048806]; genitalia morphogenesis [GO:0035112]; hard palate morphogenesis [GO:1905748]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; learned vocalization behavior [GO:0098583]; mastication [GO:0071626]; negative regulation of relaxation of muscle [GO:1901078]; negative regulation of saliva secretion [GO:1905747]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; peristalsis [GO:0030432]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of muscle organ development [GO:0048634]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory organ development [GO:0007423]; thorax and anterior abdomen determination [GO:0007356]; trigeminal nerve development [GO:0021559]; vestibulocochlear nerve formation [GO:0021650]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q92887	reviewed	MRP2_HUMAN	ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2)	ABCC2 CMOAT CMOAT1 CMRP MRP2	Homo sapiens (Human)	1545	FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505). {ECO:0000269|PubMed:10220572, ECO:0000269|PubMed:10421658, ECO:0000269|PubMed:11500505, ECO:0000269|PubMed:12441801, ECO:0000269|PubMed:16332456}.		bile acid and bile salt transport [GO:0015721]; bilirubin transport [GO:0015723]; heme catabolic process [GO:0042167]; leukotriene transport [GO:0071716]; negative regulation of gene expression [GO:0010629]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic export from cell [GO:0046618]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport across blood-brain barrier [GO:1990962]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; intercellular canaliculus [GO:0046581]; plasma membrane [GO:0005886]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; bilirubin transmembrane transporter activity [GO:0015127]; organic anion transmembrane transporter activity [GO:0008514]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; intercellular canaliculus [GO:0046581]; plasma membrane [GO:0005886]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; bilirubin transmembrane transporter activity [GO:0015127]; organic anion transmembrane transporter activity [GO:0008514]; xenobiotic transmembrane transporter activity [GO:0042910]; bile acid and bile salt transport [GO:0015721]; bilirubin transport [GO:0015723]; heme catabolic process [GO:0042167]; leukotriene transport [GO:0071716]; negative regulation of gene expression [GO:0010629]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic export from cell [GO:0046618]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport across blood-brain barrier [GO:1990962]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:10220572, ECO:0000269|PubMed:11093739, ECO:0000269|PubMed:28408210}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the apical membrane of enterocytes. {ECO:0000269|PubMed:28408210}.
Q92888	reviewed	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)	ARHGEF1	Homo sapiens (Human)	912	FUNCTION: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:9641915, PubMed:9641916, PubMed:8810315, PubMed:30521495). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). {ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}.		G protein-coupled receptor signaling pathway [GO:0007186]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10747909}. Membrane {ECO:0000269|PubMed:10747909}. Note=Translocated to the membrane by activated GNA13 or LPA stimulation.
Q92889	reviewed	XPF_HUMAN	DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein)	ERCC4 ERCC11 XPF	Homo sapiens (Human)	916	FUNCTION: Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. {ECO:0000269|PubMed:10413517, ECO:0000269|PubMed:11790111, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:24027083, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:8797827}.		cellular response to UV [GO:0034644]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of double-stranded telomeric DNA binding [GO:1905768]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of telomere maintenance [GO:0032205]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair involved in interstrand cross-link repair [GO:1901255]; regulation of autophagy [GO:0010506]; resolution of meiotic recombination intermediates [GO:0000712]; response to UV [GO:0009411]; telomere maintenance [GO:0000723]; telomeric DNA-containing double minutes formation [GO:0061819]; UV protection [GO:0009650]	chromosome, telomeric region [GO:0000781]; ERCC4-ERCC1 complex [GO:0070522]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 1 complex [GO:0000110]; nucleus [GO:0005634]	damaged DNA binding [GO:0003684]; DNA endonuclease activity [GO:0004520]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; single-stranded DNA binding [GO:0003697]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; TFIID-class transcription factor complex binding [GO:0001094]	chromosome, telomeric region [GO:0000781]; ERCC4-ERCC1 complex [GO:0070522]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 1 complex [GO:0000110]; nucleus [GO:0005634]; damaged DNA binding [GO:0003684]; DNA endonuclease activity [GO:0004520]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; single-stranded DNA binding [GO:0003697]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; TFIID-class transcription factor complex binding [GO:0001094]; cellular response to UV [GO:0034644]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of double-stranded telomeric DNA binding [GO:1905768]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of telomere maintenance [GO:0032205]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair involved in interstrand cross-link repair [GO:1901255]; regulation of autophagy [GO:0010506]; resolution of meiotic recombination intermediates [GO:0000712]; response to UV [GO:0009411]; telomere maintenance [GO:0000723]; telomeric DNA-containing double minutes formation [GO:0061819]; UV protection [GO:0009650]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19596235}. Chromosome {ECO:0000269|PubMed:11790111}. Note=Localizes to sites of DNA damage. {ECO:0000269|PubMed:11790111}.
Q92890	reviewed	UFD1_HUMAN	Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1)	UFD1 UFD1L	Homo sapiens (Human)	307	FUNCTION: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES53, ECO:0000269|PubMed:26471729}.	MISCELLANEOUS: [Isoform Short]: Major isoform.	ER-associated misfolded protein catabolic process [GO:0071712]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; retrograde protein transport, ER to cytosol [GO:0030970]; skeletal system development [GO:0001501]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; UFD1-NPL4 complex [GO:0036501]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	cysteine-type deubiquitinase activity [GO:0004843]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; polyubiquitin modification-dependent protein binding [GO:0031593]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; UFD1-NPL4 complex [GO:0036501]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; cysteine-type deubiquitinase activity [GO:0004843]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; polyubiquitin modification-dependent protein binding [GO:0031593]; ER-associated misfolded protein catabolic process [GO:0071712]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; retrograde protein transport, ER to cytosol [GO:0030970]; skeletal system development [GO:0001501]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ES53}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ES53}.
Q92896	reviewed	GSLG1_HUMAN	Golgi apparatus protein 1 (CFR-1) (Cysteine-rich fibroblast growth factor receptor) (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160)	GLG1 CFR1 ESL1 MG160	Homo sapiens (Human)	1179	FUNCTION: Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). {ECO:0000269|PubMed:8985126}.		bone morphogenesis [GO:0060349]; negative regulation of protein processing [GO:0010955]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein processing [GO:0016485]; regulation of chondrocyte differentiation [GO:0032330]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	fibroblast growth factor binding [GO:0017134]; signaling receptor binding [GO:0005102]	cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; fibroblast growth factor binding [GO:0017134]; signaling receptor binding [GO:0005102]; bone morphogenesis [GO:0060349]; negative regulation of protein processing [GO:0010955]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein processing [GO:0016485]; regulation of chondrocyte differentiation [GO:0032330]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:2355176}; Single-pass type I membrane protein {ECO:0000255}. Golgi outpost {ECO:0000250|UniProtKB:Q62638}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q62638}. Note=Golgi medial cisternae. Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. {ECO:0000250|UniProtKB:Q62638}.
Q92900	reviewed	RENT1_HUMAN	Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1)	UPF1 KIAA0221 RENT1	Homo sapiens (Human)	1129	FUNCTION: RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; cell cycle phase transition [GO:0044770]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; histone mRNA catabolic process [GO:0071044]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of telomere maintenance [GO:0032204]; regulation of translational termination [GO:0006449]; telomere maintenance via semi-conservative replication [GO:0032201]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; supraspliceosomal complex [GO:0044530]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; double-stranded DNA helicase activity [GO:0036121]; helicase activity [GO:0004386]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; telomeric DNA binding [GO:0042162]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; supraspliceosomal complex [GO:0044530]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; double-stranded DNA helicase activity [GO:0036121]; helicase activity [GO:0004386]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; telomeric DNA binding [GO:0042162]; zinc ion binding [GO:0008270]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; cell cycle phase transition [GO:0044770]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; histone mRNA catabolic process [GO:0071044]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of telomere maintenance [GO:0032204]; regulation of translational termination [GO:0006449]; telomere maintenance via semi-conservative replication [GO:0032201]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11163187}. Cytoplasm, P-body. Nucleus {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:18362360}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9EPU0}. Note=Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm. Localized in the chromatoid bodies of round spermatids (By similarity). {ECO:0000250|UniProtKB:Q9EPU0}.
Q92901	reviewed	RL3L_HUMAN	Ribosomal protein uL3-like (60S ribosomal protein L3-like) (Large ribosomal subunit protein uL3-like)	RPL3L	Homo sapiens (Human)	407	FUNCTION: Heart- and skeletal muscle-specific component of the ribosome, which regulates muscle function. Component of the large ribosomal subunit in striated muscle cells: replaces the RPL3 paralog in the ribosome in these cells. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Inhibits myotube growth and muscle function. {ECO:0000250|UniProtKB:E9PWZ3}.		negative regulation of myotube differentiation [GO:0010832]; regulation of striated muscle tissue development [GO:0016202]; translation [GO:0006412]	cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; ribosome [GO:0005840]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; ribosome [GO:0005840]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; negative regulation of myotube differentiation [GO:0010832]; regulation of striated muscle tissue development [GO:0016202]; translation [GO:0006412]	
Q92902	reviewed	HPS1_HUMAN	BLOC-3 complex member HPS1 (Hermansky-Pudlak syndrome 1 protein)	HPS1 HPS	Homo sapiens (Human)	700	FUNCTION: Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991). {ECO:0000269|PubMed:23084991}.		intracellular transport [GO:0046907]; lysosome organization [GO:0007040]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; response to stimulus [GO:0050896]; vesicle-mediated transport [GO:0016192]; visual perception [GO:0007601]	BLOC-3 complex [GO:0031085]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosome [GO:0005764]	guanyl-nucleotide exchange factor activity [GO:0005085]; protein dimerization activity [GO:0046983]	BLOC-3 complex [GO:0031085]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosome [GO:0005764]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein dimerization activity [GO:0046983]; intracellular transport [GO:0046907]; lysosome organization [GO:0007040]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; response to stimulus [GO:0050896]; vesicle-mediated transport [GO:0016192]; visual perception [GO:0007601]	
Q92903	reviewed	CDS1_HUMAN	Phosphatidate cytidylyltransferase 1 (EC 2.7.7.41) (CDP-DAG synthase 1) (CDP-DG synthase 1) (CDP-diacylglycerol synthase 1) (CDS 1) (CDP-diglyceride pyrophosphorylase 1) (CDP-diglyceride synthase 1) (CTP:phosphatidate cytidylyltransferase 1)	CDS1 CDS	Homo sapiens (Human)	461	FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:9407135, PubMed:25375833). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (PubMed:25375833). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). Positively regulates the differentiation and development of adipocytes (By similarity). {ECO:0000250|UniProtKB:P98191, ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309, ECO:0000269|PubMed:9407135}.		CDP-diacylglycerol biosynthetic process [GO:0016024]; lipid droplet formation [GO:0140042]; phosphatidylinositol biosynthetic process [GO:0006661]; phototransduction [GO:0007602]; positive regulation of fat cell differentiation [GO:0045600]; signal transduction [GO:0007165]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	diacylglycerol cholinephosphotransferase activity [GO:0004142]; phosphatidate cytidylyltransferase activity [GO:0004605]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; diacylglycerol cholinephosphotransferase activity [GO:0004142]; phosphatidate cytidylyltransferase activity [GO:0004605]; CDP-diacylglycerol biosynthetic process [GO:0016024]; lipid droplet formation [GO:0140042]; phosphatidylinositol biosynthetic process [GO:0006661]; phototransduction [GO:0007602]; positive regulation of fat cell differentiation [GO:0045600]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}; Multi-pass membrane protein {ECO:0000255}.
Q92904	reviewed	DAZL_HUMAN	Deleted in azoospermia-like (DAZ homolog) (DAZ-like autosomal) (Deleted in azoospermia-like 1) (SPGY-like-autosomal)	DAZL DAZH DAZL1 DAZLA SPGYLA	Homo sapiens (Human)	295	FUNCTION: RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). {ECO:0000250}.		3'-UTR-mediated mRNA stabilization [GO:0070935]; germ cell development [GO:0007281]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; germ cell development [GO:0007281]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward. {ECO:0000250}.
Q92905	reviewed	CSN5_HUMAN	COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)	COPS5 CSN5 JAB1	Homo sapiens (Human)	334	FUNCTION: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399, ECO:0000269|PubMed:9535219}.	MISCELLANEOUS: The CSN complex is associated with some 'Lys-63'-specific deubiquitination. Such activity is however not mediated by the core CSN complex but by the BRCC3/BRCC36 component of the BRISC complex.	exosomal secretion [GO:1990182]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein deneddylation [GO:0000338]; protein deubiquitination [GO:0016579]; protein neddylation [GO:0045116]; regulation of cell cycle [GO:0051726]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; regulation of JNK cascade [GO:0046328]; regulation of protein neddylation [GO:2000434]; translation [GO:0006412]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 3 complex [GO:0005852]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; synaptic vesicle [GO:0008021]	deNEDDylase activity [GO:0019784]; enzyme binding [GO:0019899]; macrophage migration inhibitory factor binding [GO:0035718]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; transcription coactivator activity [GO:0003713]; translation initiation factor activity [GO:0003743]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 3 complex [GO:0005852]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; synaptic vesicle [GO:0008021]; deNEDDylase activity [GO:0019784]; enzyme binding [GO:0019899]; macrophage migration inhibitory factor binding [GO:0035718]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; transcription coactivator activity [GO:0003713]; translation initiation factor activity [GO:0003743]; exosomal secretion [GO:1990182]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein deneddylation [GO:0000338]; protein deubiquitination [GO:0016579]; protein neddylation [GO:0045116]; regulation of cell cycle [GO:0051726]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; regulation of JNK cascade [GO:0046328]; regulation of protein neddylation [GO:2000434]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399, ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9535219}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:21102408}. Note=Nuclear localization is diminished in the presence of IFIT3. {ECO:0000269|PubMed:17050680}.
Q92908	reviewed	GATA6_HUMAN	Transcription factor GATA-6 (GATA-binding factor 6)	GATA6	Homo sapiens (Human)	595	FUNCTION: Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341). {ECO:0000250|UniProtKB:Q61169, ECO:0000269|PubMed:16968778, ECO:0000269|PubMed:19666519, ECO:0000269|PubMed:22750565, ECO:0000269|PubMed:22824924, ECO:0000269|PubMed:27756709, ECO:0000269|PubMed:33082341, ECO:0000269|PubMed:9315713}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at Met-147 of isoform 1. {ECO:0000305}.	animal organ formation [GO:0048645]; atrioventricular canal development [GO:0036302]; atrioventricular node development [GO:0003162]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cell fate commitment [GO:0045165]; cellular response to BMP stimulus [GO:0071773]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to hypoxia [GO:0071456]; club cell differentiation [GO:0060486]; endodermal cell fate determination [GO:0007493]; epithelial cell differentiation [GO:0030855]; G1 to G0 transition involved in cell differentiation [GO:0070315]; gene expression [GO:0010467]; heart contraction [GO:0060047]; in utero embryonic development [GO:0001701]; intestinal epithelial cell differentiation [GO:0060575]; liver development [GO:0001889]; lung saccule development [GO:0060430]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of sebum secreting cell proliferation [GO:1904003]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta1 production [GO:0032911]; negative regulation of transforming growth factor beta2 production [GO:0032912]; odontogenesis of dentin-containing tooth [GO:0042475]; outflow tract septum morphogenesis [GO:0003148]; pancreatic A cell differentiation [GO:0003310]; phospholipid metabolic process [GO:0006644]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac muscle myoblast proliferation [GO:0110024]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta activation [GO:1901390]; regulation of antimicrobial humoral response [GO:0002759]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to growth factor [GO:0070848]; response to retinoic acid [GO:0032526]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; sebaceous gland cell differentiation [GO:0001949]; sinoatrial node development [GO:0003163]; skin epidermis development [GO:0098773]; smooth muscle cell differentiation [GO:0051145]; stem cell differentiation [GO:0048863]; tube morphogenesis [GO:0035239]; type B pancreatic cell differentiation [GO:0003309]; type II pneumocyte differentiation [GO:0060510]	chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; NFAT protein binding [GO:0051525]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; NFAT protein binding [GO:0051525]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]; animal organ formation [GO:0048645]; atrioventricular canal development [GO:0036302]; atrioventricular node development [GO:0003162]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cell fate commitment [GO:0045165]; cellular response to BMP stimulus [GO:0071773]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to hypoxia [GO:0071456]; club cell differentiation [GO:0060486]; endodermal cell fate determination [GO:0007493]; epithelial cell differentiation [GO:0030855]; G1 to G0 transition involved in cell differentiation [GO:0070315]; gene expression [GO:0010467]; heart contraction [GO:0060047]; in utero embryonic development [GO:0001701]; intestinal epithelial cell differentiation [GO:0060575]; liver development [GO:0001889]; lung saccule development [GO:0060430]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of sebum secreting cell proliferation [GO:1904003]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta1 production [GO:0032911]; negative regulation of transforming growth factor beta2 production [GO:0032912]; odontogenesis of dentin-containing tooth [GO:0042475]; outflow tract septum morphogenesis [GO:0003148]; pancreatic A cell differentiation [GO:0003310]; phospholipid metabolic process [GO:0006644]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac muscle myoblast proliferation [GO:0110024]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta activation [GO:1901390]; regulation of antimicrobial humoral response [GO:0002759]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to growth factor [GO:0070848]; response to retinoic acid [GO:0032526]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; sebaceous gland cell differentiation [GO:0001949]; sinoatrial node development [GO:0003163]; skin epidermis development [GO:0098773]; smooth muscle cell differentiation [GO:0051145]; stem cell differentiation [GO:0048863]; tube morphogenesis [GO:0035239]; type B pancreatic cell differentiation [GO:0003309]; type II pneumocyte differentiation [GO:0060510]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19666519, ECO:0000269|PubMed:27756709}.
Q92911	reviewed	SC5A5_HUMAN	Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Natrium iodide transporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5)	SLC5A5 NIS	Homo sapiens (Human)	643	FUNCTION: Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:8806637, PubMed:9329364, PubMed:20797386, PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:31310151, PubMed:32084174). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351). {ECO:0000269|PubMed:12488351, ECO:0000269|PubMed:18372236, ECO:0000269|PubMed:18708479, ECO:0000269|PubMed:20797386, ECO:0000269|PubMed:31310151, ECO:0000269|PubMed:32084174, ECO:0000269|PubMed:8806637, ECO:0000269|PubMed:9329364}.		cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to Thyroid stimulating hormone [GO:1904401]; iodide transmembrane transport [GO:1904200]; iodide transport [GO:0015705]; monoatomic ion transport [GO:0006811]; sodium ion transport [GO:0006814]; thyroid hormone generation [GO:0006590]; transport across blood-brain barrier [GO:0150104]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	iodide transmembrane transporter activity [GO:0015111]; monoatomic anion:sodium symporter activity [GO:0015373]; protein homodimerization activity [GO:0042803]; sodium:iodide symporter activity [GO:0008507]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; iodide transmembrane transporter activity [GO:0015111]; monoatomic anion:sodium symporter activity [GO:0015373]; protein homodimerization activity [GO:0042803]; sodium:iodide symporter activity [GO:0008507]; cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to Thyroid stimulating hormone [GO:1904401]; iodide transmembrane transport [GO:1904200]; iodide transport [GO:0015705]; monoatomic ion transport [GO:0006811]; sodium ion transport [GO:0006814]; thyroid hormone generation [GO:0006590]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18372236, ECO:0000269|PubMed:18708479, ECO:0000269|PubMed:20797386, ECO:0000269|PubMed:31310151}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:18372236, ECO:0000269|PubMed:31310151}.
Q92913	reviewed	FGF13_HUMAN	Fibroblast growth factor 13 (FGF-13) (Fibroblast growth factor homologous factor 2) (FHF-2)	FGF13 FHF2	Homo sapiens (Human)	245	FUNCTION: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). Regulates voltage-gated sodium channel transport and function (PubMed:15282281, PubMed:33245860, PubMed:36696443). May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity). {ECO:0000250|UniProtKB:P70377, ECO:0000269|PubMed:15282281, ECO:0000269|PubMed:33245860, ECO:0000269|PubMed:36696443}.		branching morphogenesis of a nerve [GO:0048755]; cell-cell signaling [GO:0007267]; cerebral cortex cell migration [GO:0021795]; establishment of neuroblast polarity [GO:0045200]; hippocampus development [GO:0021766]; inhibitory synapse assembly [GO:1904862]; learning [GO:0007612]; MAPK cascade [GO:0000165]; memory [GO:0007613]; microtubule polymerization [GO:0046785]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; positive regulation of voltage-gated sodium channel activity [GO:1905152]; protein localization to plasma membrane [GO:0072659]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; signal transduction [GO:0007165]; sodium ion transport [GO:0006814]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	beta-tubulin binding [GO:0048487]; growth factor activity [GO:0008083]; microtubule binding [GO:0008017]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; beta-tubulin binding [GO:0048487]; growth factor activity [GO:0008083]; microtubule binding [GO:0008017]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; branching morphogenesis of a nerve [GO:0048755]; cell-cell signaling [GO:0007267]; cerebral cortex cell migration [GO:0021795]; establishment of neuroblast polarity [GO:0045200]; hippocampus development [GO:0021766]; inhibitory synapse assembly [GO:1904862]; learning [GO:0007612]; MAPK cascade [GO:0000165]; memory [GO:0007613]; microtubule polymerization [GO:0046785]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; positive regulation of voltage-gated sodium channel activity [GO:1905152]; protein localization to plasma membrane [GO:0072659]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; signal transduction [GO:0007165]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:10644718}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:10644718}. Nucleus {ECO:0000269|PubMed:10644718}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000305|PubMed:10644718}. Nucleus {ECO:0000305|PubMed:10644718}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000250|UniProtKB:P61329}. Nucleus {ECO:0000250|UniProtKB:P61329}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000250|UniProtKB:P61329}. Nucleus {ECO:0000250|UniProtKB:P61329}.; SUBCELLULAR LOCATION: Cell projection, filopodium {ECO:0000250|UniProtKB:P70377}. Cell projection, growth cone {ECO:0000250|UniProtKB:P70377}. Cell projection, dendrite {ECO:0000250|UniProtKB:P70377}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P70377}. Cytoplasm {ECO:0000250|UniProtKB:P70377}. Note=Not secreted. Localizes to the lateral membrane and intercalated disks of myocytes. {ECO:0000250|UniProtKB:P70377}.
Q92915	reviewed	FGF14_HUMAN	Fibroblast growth factor 14 (FGF-14) (Fibroblast growth factor homologous factor 4) (FHF-4)	FGF14 FHF4	Homo sapiens (Human)	247	FUNCTION: Probably involved in nervous system development and function.		cell-cell signaling [GO:0007267]; JNK cascade [GO:0007254]; nervous system development [GO:0007399]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	growth factor activity [GO:0008083]; heparin binding [GO:0008201]; sodium channel regulator activity [GO:0017080]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; sodium channel regulator activity [GO:0017080]; cell-cell signaling [GO:0007267]; JNK cascade [GO:0007254]; nervous system development [GO:0007399]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q92917	reviewed	GPKOW_HUMAN	G-patch domain and KOW motifs-containing protein (G-patch domain-containing protein 5) (Protein MOS2 homolog) (Protein T54)	GPKOW GPATC5 GPATCH5 T54	Homo sapiens (Human)	476	FUNCTION: RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:25296192, ECO:0000305|PubMed:33509932}.		mRNA splicing, via spliceosome [GO:0000398]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:25296192}.
Q92918	reviewed	M4K1_HUMAN	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)	MAP4K1 HPK1	Homo sapiens (Human)	833	FUNCTION: Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:8824585}.		cell population proliferation [GO:0008283]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of MAPK cascade [GO:0043410]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; membrane [GO:0016020]	ATP binding [GO:0005524]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; membrane [GO:0016020]; ATP binding [GO:0005524]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell population proliferation [GO:0008283]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of MAPK cascade [GO:0043410]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	
Q92922	reviewed	SMRC1_HUMAN	SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1)	SMARCC1 BAF155	Homo sapiens (Human)	1105	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.		animal organ morphogenesis [GO:0009887]; chromatin remodeling [GO:0006338]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell differentiation [GO:0045596]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	brahma complex [GO:0035060]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; GBAF complex [GO:0140288]; kinetochore [GO:0000776]; male germ cell nucleus [GO:0001673]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; XY body [GO:0001741]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; transcription coactivator activity [GO:0003713]	brahma complex [GO:0035060]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; GBAF complex [GO:0140288]; kinetochore [GO:0000776]; male germ cell nucleus [GO:0001673]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; XY body [GO:0001741]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; transcription coactivator activity [GO:0003713]; animal organ morphogenesis [GO:0009887]; chromatin remodeling [GO:0006338]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell differentiation [GO:0045596]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28753627}. Cytoplasm {ECO:0000269|PubMed:28753627}.
Q92925	reviewed	SMRD2_HUMAN	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B) (BAF60B)	SMARCD2 BAF60B PRO2451	Homo sapiens (Human)	531	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (PubMed:28369036). {ECO:0000269|PubMed:28369036, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.	MISCELLANEOUS: [Isoform 2]: Produced by aberrant splicing sites. {ECO:0000305}.	chromatin remodeling [GO:0006338]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; chromatin remodeling [GO:0006338]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q92930	reviewed	RAB8B_HUMAN	Ras-related protein Rab-8B	RAB8B	Homo sapiens (Human)	207	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). May participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). {ECO:0000250, ECO:0000269|PubMed:32344433}.		antigen processing and presentation [GO:0019882]; cell-substrate junction organization [GO:0150115]; endocytic recycling [GO:0032456]; Golgi vesicle fusion to target membrane [GO:0048210]; positive regulation of cell projection organization [GO:0031346]; positive regulation of corticotropin secretion [GO:0051461]; protein import into peroxisome membrane [GO:0045046]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904]	cell tip [GO:0051286]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network transport vesicle [GO:0030140]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; signaling receptor binding [GO:0005102]; TPR domain binding [GO:0030911]	cell tip [GO:0051286]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network transport vesicle [GO:0030140]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; signaling receptor binding [GO:0005102]; TPR domain binding [GO:0030911]; antigen processing and presentation [GO:0019882]; cell-substrate junction organization [GO:0150115]; endocytic recycling [GO:0032456]; Golgi vesicle fusion to target membrane [GO:0048210]; positive regulation of cell projection organization [GO:0031346]; positive regulation of corticotropin secretion [GO:0051461]; protein import into peroxisome membrane [GO:0045046]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:21255211}; Lipid-anchor {ECO:0000269|PubMed:21255211}; Cytoplasmic side {ECO:0000269|PubMed:21255211}. Endosome membrane {ECO:0000269|PubMed:32344433}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. Colocalized with MICAL1, GRAF1/ARHGAP26 and GRAF2/ARHGAP10 on endosomal tubules (PubMed:32344433). {ECO:0000269|PubMed:32344433}.
Q92932	reviewed	PTPR2_HUMAN	Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60]	PTPRN2 KIAA0387	Homo sapiens (Human)	1015	FUNCTION: Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475, ECO:0000269|PubMed:26620550}.		insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; lipid metabolic process [GO:0006629]; neurotransmitter secretion [GO:0007269]; protein dephosphorylation [GO:0006470]; regulation of secretion [GO:0051046]	ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]	transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; lipid metabolic process [GO:0006629]; neurotransmitter secretion [GO:0007269]; protein dephosphorylation [GO:0006470]; regulation of secretion [GO:0051046]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P80560}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P80560}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P80560}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P80560}. Note=Predominantly found on dense-core secretory granules. Sorting to secretory granules in part is dependent of the N-terminal propeptide domain of the precursor and its interaction with CPE (By similarity). Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles involving clathrin-dependent AP2-mediated endocytosis. Recycled via STX6- but not TTTGN1/TGN38-containing compartments (By similarity). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475}.; SUBCELLULAR LOCATION: [IA-2beta60]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}.
Q92934	reviewed	BAD_HUMAN	Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)	BAD BBC6 BCL2L8	Homo sapiens (Human)	168	FUNCTION: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}.		activation of cysteine-type endopeptidase activity [GO:0097202]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; ADP metabolic process [GO:0046031]; apoptotic process [GO:0006915]; ATP metabolic process [GO:0046034]; cellular response to hypoxia [GO:0071456]; cellular response to lipid [GO:0071396]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; glucose catabolic process [GO:0006007]; glucose homeostasis [GO:0042593]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; pore complex assembly [GO:0046931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of glucokinase activity [GO:0033133]; positive regulation of insulin secretion [GO:0032024]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902220]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of type B pancreatic cell development [GO:2000078]; regulation of mitochondrial membrane permeability [GO:0046902]; release of cytochrome c from mitochondria [GO:0001836]; type B pancreatic cell proliferation [GO:0044342]	BAD-BCL-2 complex [GO:0097138]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]	BAD-BCL-2 complex [GO:0097138]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; activation of cysteine-type endopeptidase activity [GO:0097202]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; ADP metabolic process [GO:0046031]; apoptotic process [GO:0006915]; ATP metabolic process [GO:0046034]; cellular response to hypoxia [GO:0071456]; cellular response to lipid [GO:0071396]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; glucose catabolic process [GO:0006007]; glucose homeostasis [GO:0042593]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; pore complex assembly [GO:0046931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of glucokinase activity [GO:0033133]; positive regulation of insulin secretion [GO:0032024]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902220]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of type B pancreatic cell development [GO:2000078]; regulation of mitochondrial membrane permeability [GO:0046902]; release of cytochrome c from mitochondria [GO:0001836]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Mitochondrion outer membrane. Cytoplasm {ECO:0000250|UniProtKB:Q61337}. Note=Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm. {ECO:0000250|UniProtKB:Q61337}.
Q92935	reviewed	EXTL1_HUMAN	Exostosin-like 1 (EC 2.4.1.224) (Exostosin-L) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostosis-like protein)	EXTL1 EXTL	Homo sapiens (Human)	676	FUNCTION: Glycosyltransferase required for the biosynthesis of heparan-sulfate (HS) (PubMed:11390981). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity) (PubMed:11390981). Appears to lack GlcNAcT I and GlcAT-II activities (PubMed:11390981). {ECO:0000269|PubMed:11390981}.		heparan sulfate proteoglycan biosynthetic process [GO:0015012]; skeletal system development [GO:0001501]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q92945	reviewed	FUBP2_HUMAN	Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75)	KHSRP FUBP2	Homo sapiens (Human)	711	FUNCTION: Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to cytokine stimulus [GO:0071345]; miRNA metabolic process [GO:0010586]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of mRNA stability [GO:0043488]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to cytokine stimulus [GO:0071345]; miRNA metabolic process [GO:0010586]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of mRNA stability [GO:0043488]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19198587}. Cytoplasm {ECO:0000269|PubMed:19198587}. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. {ECO:0000250}.
Q92947	reviewed	GCDH_HUMAN	Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6)	GCDH	Homo sapiens (Human)	438	FUNCTION: Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive. {ECO:0000269|PubMed:17176108, ECO:0000269|PubMed:6423663, ECO:0000269|PubMed:8541831}.		fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty-acyl-CoA biosynthetic process [GO:0046949]; tryptophan metabolic process [GO:0006568]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	fatty-acyl-CoA binding [GO:0000062]; flavin adenine dinucleotide binding [GO:0050660]; glutaryl-CoA dehydrogenase activity [GO:0004361]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; fatty-acyl-CoA binding [GO:0000062]; flavin adenine dinucleotide binding [GO:0050660]; glutaryl-CoA dehydrogenase activity [GO:0004361]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty-acyl-CoA biosynthetic process [GO:0046949]; tryptophan metabolic process [GO:0006568]	SUBCELLULAR LOCATION: Mitochondrion matrix.
Q92949	reviewed	FOXJ1_HUMAN	Forkhead box protein J1 (Forkhead-related protein FKHL13) (Hepatocyte nuclear factor 3 forkhead homolog 4) (HFH-4)	FOXJ1 FKHL13 HFH4	Homo sapiens (Human)	421	FUNCTION: Transcription factor specifically required for the formation of motile cilia (PubMed:31630787). Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung. {ECO:0000250|UniProtKB:Q61660, ECO:0000269|PubMed:31630787}.		actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; axoneme assembly [GO:0035082]; brain development [GO:0007420]; cell maturation [GO:0048469]; central tolerance induction [GO:0002508]; ciliary basal body organization [GO:0032053]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; epithelium development [GO:0060429]; establishment of apical/basal cell polarity [GO:0035089]; glomerular parietal epithelial cell development [GO:0072016]; heart development [GO:0007507]; humoral immune response [GO:0006959]; leukocyte migration [GO:0050900]; lung epithelium development [GO:0060428]; metanephric part of ureteric bud development [GO:0035502]; motile cilium assembly [GO:0044458]; negative regulation of B cell activation [GO:0050869]; negative regulation of germinal center formation [GO:0002635]; negative regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002924]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell differentiation in thymus [GO:0033085]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pattern specification process [GO:0007389]; positive regulation of central B cell tolerance induction [GO:0002897]; positive regulation of lung ciliated cell differentiation [GO:1901248]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; axoneme assembly [GO:0035082]; brain development [GO:0007420]; cell maturation [GO:0048469]; central tolerance induction [GO:0002508]; ciliary basal body organization [GO:0032053]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; epithelium development [GO:0060429]; establishment of apical/basal cell polarity [GO:0035089]; glomerular parietal epithelial cell development [GO:0072016]; heart development [GO:0007507]; humoral immune response [GO:0006959]; leukocyte migration [GO:0050900]; lung epithelium development [GO:0060428]; metanephric part of ureteric bud development [GO:0035502]; motile cilium assembly [GO:0044458]; negative regulation of B cell activation [GO:0050869]; negative regulation of germinal center formation [GO:0002635]; negative regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002924]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell differentiation in thymus [GO:0033085]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pattern specification process [GO:0007389]; positive regulation of central B cell tolerance induction [GO:0002897]; positive regulation of lung ciliated cell differentiation [GO:1901248]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61660}.
Q92952	reviewed	KCNN1_HUMAN	Small conductance calcium-activated potassium channel protein 1 (SK1) (SKCa 1) (SKCa1) (KCa2.1)	KCNN1 SK	Homo sapiens (Human)	543	FUNCTION: Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:8781233, PubMed:9287325, PubMed:17142458). Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity). {ECO:0000250|UniProtKB:Q9EQR3, ECO:0000269|PubMed:17142458, ECO:0000269|PubMed:8781233, ECO:0000269|PubMed:9287325}.		chemical synaptic transmission [GO:0007268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]	neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]	calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; small conductance calcium-activated potassium channel activity [GO:0016286]	neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]; calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; small conductance calcium-activated potassium channel activity [GO:0016286]; chemical synaptic transmission [GO:0007268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q92953	reviewed	KCNB2_HUMAN	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2)	KCNB2	Homo sapiens (Human)	911	FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. {ECO:0000250|UniProtKB:A6H8H5, ECO:0000250|UniProtKB:Q63099}.		potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of smooth muscle contraction [GO:0006940]	dendrite [GO:0030425]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; protein heterodimerization activity [GO:0046982]	dendrite [GO:0030425]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; protein heterodimerization activity [GO:0046982]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of smooth muscle contraction [GO:0006940]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q63099}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q63099}. Perikaryon {ECO:0000250|UniProtKB:Q63099}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63099}. Note=Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons. {ECO:0000250|UniProtKB:Q63099}.
Q92954	reviewed	PRG4_HUMAN	Proteoglycan 4 (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Cleaved into: Proteoglycan 4 C-terminal part]	PRG4 MSF SZP	Homo sapiens (Human)	1404	FUNCTION: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.; FUNCTION: Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.	MISCELLANEOUS: Different forms varying in molecular weight have been observed. Such forms are possibly due to different levels of glycosylation and protein cleavage (By similarity). {ECO:0000250}.	immune response [GO:0006955]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]	polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14976050, ECO:0000269|PubMed:32144329}.
Q92956	reviewed	TNR14_HUMAN	Tumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270)	TNFRSF14 HVEA HVEM UNQ329/PRO509	Homo sapiens (Human)	283	FUNCTION: Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:9462508, PubMed:10754304, PubMed:18193050, PubMed:23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044) (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044) (By similarity). {ECO:0000250|UniProtKB:Q80WM9, ECO:0000269|PubMed:10754304, ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:19915044, ECO:0000269|PubMed:23761635, ECO:0000269|PubMed:9153189, ECO:0000269|PubMed:9162022, ECO:0000269|PubMed:9462508}.; FUNCTION: (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:9696799}.; FUNCTION: (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:9696799}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of adaptive immune memory response [GO:1905675]; negative regulation of alpha-beta T cell proliferation [GO:0046642]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of T cell migration [GO:2000406]; T cell costimulation [GO:0031295]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	cytokine binding [GO:0019955]; tumor necrosis factor receptor activity [GO:0005031]; ubiquitin protein ligase binding [GO:0031625]; virus receptor activity [GO:0001618]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; cytokine binding [GO:0019955]; tumor necrosis factor receptor activity [GO:0005031]; ubiquitin protein ligase binding [GO:0031625]; virus receptor activity [GO:0001618]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of adaptive immune memory response [GO:1905675]; negative regulation of alpha-beta T cell proliferation [GO:0046642]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of T cell migration [GO:2000406]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19915044}; Single-pass type I membrane protein {ECO:0000305}.
Q92959	reviewed	SO2A1_HUMAN	Solute carrier organic anion transporter family member 2A1 (SLCO2A1) (OATP2A1) (PHOAR2) (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2) (SLC21A2)	SLCO2A1 OATP2A1 SLC21A2	Homo sapiens (Human)	643	FUNCTION: Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane (PubMed:8787677, PubMed:11997326, PubMed:26692285). PGs and thromboxanes play fundamental roles in diverse functions such as intraocular pressure, gastric acid secretion, renal salt and water transport, vascular tone, and fever (PubMed:15044627). Plays a role in the clearance of PGs from the circulation through cellular uptake, which allows cytoplasmic oxidation and PG signal termination (PubMed:8787677). PG uptake is dependent upon membrane potential and involves exchange of a monovalent anionic substrate (PGs exist physiologically as an anionic monovalent form) with a stoichiometry of 1:1 for divalent anions or of 1:2 for monovalent anions (PubMed:29204966). Uses lactate, generated by glycolysis, as a counter-substrate to mediate PGE2 influx and efflux (PubMed:11997326). Under nonglycolytic conditions, metabolites other than lactate might serve as counter-substrates (PubMed:11997326). Although the mechanism is not clear, this transporter can function in bidirectional mode (PubMed:29204966). When apically expressed in epithelial cells, it facilitates transcellular transport (also called vectorial release), extracting PG from the apical medium and facilitating transport across the cell toward the basolateral side, whereupon the PG exits the cell by simple diffusion (By similarity). In the renal collecting duct, regulates renal Na+ balance by removing PGE2 from apical medium (PGE2 EP4 receptor is likely localized to the luminal/apical membrane and stimulates Na+ resorption) and transporting it toward the basolateral membrane (where PGE2 EP1 and EP3 receptors inhibit Na+ resorption) (By similarity). Plays a role in endometrium during decidualization, increasing uptake of PGs by decidual cells (PubMed:16339169). Involved in critical events for ovulation (PubMed:27169804). Regulates extracellular PGE2 concentration for follicular development in the ovaries (By similarity). Expressed intracellularly, may contribute to vesicular uptake of newly synthesized intracellular PGs, thereby facilitating exocytotic secretion of PGs without being metabolized (By similarity). Essential core component of the major type of large-conductance anion channel, Maxi-Cl, which plays essential roles in inorganic anion transport, cell volume regulation and release of ATP and glutamate not only in physiological processes but also in pathological processes (By similarity). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000250|UniProtKB:Q00910, ECO:0000250|UniProtKB:Q9EPT5, ECO:0000269|PubMed:11997326, ECO:0000269|PubMed:16339169, ECO:0000269|PubMed:26692285, ECO:0000269|PubMed:27169804, ECO:0000269|PubMed:8787677, ECO:0000303|PubMed:11997326, ECO:0000303|PubMed:15044627, ECO:0000303|PubMed:29204966, ECO:0000305|PubMed:35307651}.		lipid transport [GO:0006869]; prostaglandin transport [GO:0015732]; sodium-independent organic anion transport [GO:0043252]	basal plasma membrane [GO:0009925]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]	lipid transporter activity [GO:0005319]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]	basal plasma membrane [GO:0009925]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; lipid transporter activity [GO:0005319]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; lipid transport [GO:0006869]; prostaglandin transport [GO:0015732]; sodium-independent organic anion transport [GO:0043252]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:8787677}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9EPT5}. Lysosome {ECO:0000250|UniProtKB:Q9EPT5}. Note=Localized to the basal membrane of Sertoli cells. {ECO:0000269|PubMed:35307651}.
Q92963	reviewed	RIT1_HUMAN	GTP-binding protein Rit1 (EC 3.6.5.2) (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1)	RIT1 RIBB RIT ROC1	Homo sapiens (Human)	219	FUNCTION: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. {ECO:0000269|PubMed:15632082, ECO:0000269|PubMed:23791108}.	MISCELLANEOUS: Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation.; MISCELLANEOUS: Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.	Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane.
Q92966	reviewed	SNPC3_HUMAN	snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Proximal sequence element-binding transcription factor subunit beta) (PSE-binding factor subunit beta) (PTF subunit beta) (Small nuclear RNA-activating complex polypeptide 3) (snRNA-activating protein complex 50 kDa subunit) (SNAPc 50 kDa subunit)	SNAPC3 SNAP50	Homo sapiens (Human)	411	FUNCTION: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}.		snRNA transcription [GO:0009301]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]	nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; snRNA-activating protein complex [GO:0019185]	bent DNA binding [GO:0003681]; DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]	nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; snRNA-activating protein complex [GO:0019185]; bent DNA binding [GO:0003681]; DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; snRNA transcription [GO:0009301]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus.
Q92968	reviewed	PEX13_HUMAN	Peroxisomal membrane protein PEX13 (Peroxin-13)	PEX13	Homo sapiens (Human)	403	FUNCTION: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:9653144, PubMed:8858165, PubMed:28765278). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:9653144, PubMed:8858165, PubMed:28765278). Involved in the import of PTS1- and PTS2-type containing proteins (PubMed:9653144, PubMed:8858165). {ECO:0000250|UniProtKB:P80667, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:8858165, ECO:0000269|PubMed:9653144}.		cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; fatty acid alpha-oxidation [GO:0001561]; locomotory behavior [GO:0007626]; microtubule-based peroxisome localization [GO:0060152]; neuron migration [GO:0001764]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, translocation [GO:0016561]; suckling behavior [GO:0001967]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	protein transmembrane transporter activity [GO:0008320]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein transmembrane transporter activity [GO:0008320]; cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; fatty acid alpha-oxidation [GO:0001561]; locomotory behavior [GO:0007626]; microtubule-based peroxisome localization [GO:0060152]; neuron migration [GO:0001764]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, translocation [GO:0016561]; suckling behavior [GO:0001967]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:11390669, ECO:0000269|PubMed:8858165}; Multi-pass membrane protein {ECO:0000255}.
Q92973	reviewed	TNPO1_HUMAN	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)	TNPO1 KPNB2 MIP1 TRN	Homo sapiens (Human)	898	FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). In vitro, mediates nuclear import of SRP19 (PubMed:11682607). Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571). {ECO:0000250|UniProtKB:Q8BFY9, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606, ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:8986607, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975}.		protein import into nucleus [GO:0006606]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q92974	reviewed	ARHG2_HUMAN	Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)	ARHGEF2 KIAA0651 LFP40	Homo sapiens (Human)	986	FUNCTION: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}.		actin filament organization [GO:0007015]; asymmetric neuroblast division [GO:0055059]; cell cycle [GO:0007049]; cell morphogenesis [GO:0000902]; cellular hyperosmotic response [GO:0071474]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to tumor necrosis factor [GO:0071356]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of necroptotic process [GO:0060546]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron migration [GO:2001224]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell population proliferation [GO:0042127]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; spindle [GO:0005819]; vesicle [GO:0031982]	guanyl-nucleotide exchange factor activity [GO:0005085]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; spindle [GO:0005819]; vesicle [GO:0031982]; guanyl-nucleotide exchange factor activity [GO:0005085]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]; actin filament organization [GO:0007015]; asymmetric neuroblast division [GO:0055059]; cell cycle [GO:0007049]; cell morphogenesis [GO:0000902]; cellular hyperosmotic response [GO:0071474]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to tumor necrosis factor [GO:0071356]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of necroptotic process [GO:0060546]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron migration [GO:2001224]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell population proliferation [GO:0042127]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11912491, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:9857026}. Cytoplasm {ECO:0000269|PubMed:15827085, ECO:0000269|PubMed:21887730}. Cell junction, tight junction {ECO:0000269|PubMed:19043560}. Golgi apparatus {ECO:0000269|PubMed:15827085}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17488622}. Cell projection, ruffle membrane {ECO:0000269|PubMed:19043560}. Cytoplasmic vesicle {ECO:0000269|PubMed:21887730}. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization (PubMed:15827085). Recruited into membrane ruffles induced by S.flexneri at tight junctions of polarized epithelial cells (PubMed:19043560). Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (PubMed:21887730). {ECO:0000269|PubMed:15827085, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730}.
Q92979	reviewed	NEP1_HUMAN	Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.-) (18S rRNA (pseudouridine(1248)-N1)-methyltransferase) (18S rRNA Psi1248 methyltransferase) (Nucleolar protein EMG1 homolog) (Protein C2f) (Ribosome biogenesis protein NEP1)	EMG1 C2F	Homo sapiens (Human)	244	FUNCTION: S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:Q06287, ECO:0000269|PubMed:20047967, ECO:0000269|PubMed:34516797}.		blastocyst development [GO:0001824]; nucleologenesis [GO:0017126]; ribosomal small subunit biogenesis [GO:0042274]; rRNA base methylation [GO:0070475]; rRNA processing [GO:0006364]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA (pseudouridine) methyltransferase activity [GO:0070037]; rRNA binding [GO:0019843]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA (pseudouridine) methyltransferase activity [GO:0070037]; rRNA binding [GO:0019843]; blastocyst development [GO:0001824]; nucleologenesis [GO:0017126]; ribosomal small subunit biogenesis [GO:0042274]; rRNA base methylation [GO:0070475]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11935223, ECO:0000269|PubMed:34516797}.
Q92982	reviewed	NINJ1_HUMAN	Ninjurin-1 (hNINJ1) (Nerve injury-induced protein 1) [Cleaved into: Secreted ninjurin-1 (Soluble ninjurin-1)]	NINJ1	Homo sapiens (Human)	152	FUNCTION: [Ninjurin-1]: Effector of necroptotic and pyroptotic programmed cell death that mediates plasma membrane rupture (cytolysis) (PubMed:33472215, PubMed:36468682, PubMed:37196676, PubMed:37198476). Acts downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively: oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (PubMed:33472215, PubMed:36468682, PubMed:37196676, PubMed:37198476). Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS (PubMed:26677008). Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (By similarity). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions (PubMed:22162058). Also acts as a homophilic transmembrane adhesion molecule involved in various processes such as axonal growth, cell chemotaxis and angiogenesis (PubMed:8780658, PubMed:9261151, PubMed:33028854). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM) (PubMed:33028854). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells (PubMed:22162058, PubMed:26677008, PubMed:32147432). Plays a role in nerve regeneration by promoting maturation of Schwann cells (PubMed:8780658, PubMed:9261151). Acts as a regulator of angiogenesis (PubMed:33028854). Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (By similarity). Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts (By similarity). Also involved in striated muscle growth and differentiation (By similarity). {ECO:0000250|UniProtKB:O70131, ECO:0000269|PubMed:22162058, ECO:0000269|PubMed:26677008, ECO:0000269|PubMed:32147432, ECO:0000269|PubMed:33028854, ECO:0000269|PubMed:33472215, ECO:0000269|PubMed:36468682, ECO:0000269|PubMed:37196676, ECO:0000269|PubMed:37198476, ECO:0000269|PubMed:8780658, ECO:0000269|PubMed:9261151}.; FUNCTION: [Secreted ninjurin-1]: Secreted form generated by cleavage, which has chemotactic activity (By similarity). Acts as an anti-inflammatory mediator by promoting monocyte recruitment, thereby ameliorating atherosclerosis (PubMed:32883094). {ECO:0000250|UniProtKB:O70131, ECO:0000269|PubMed:32883094}.		angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; heterotypic cell-cell adhesion [GO:0034113]; killing of cells of another organism [GO:0031640]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; muscle cell differentiation [GO:0042692]; nervous system development [GO:0007399]; positive regulation of angiogenesis [GO:0045766]; positive regulation of inflammatory response [GO:0050729]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; programmed cell death [GO:0012501]; protein homooligomerization [GO:0051260]; pyroptosis [GO:0070269]; tissue regeneration [GO:0042246]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060]	cell adhesion mediator activity [GO:0098631]; lipopolysaccharide binding [GO:0001530]; membrane destabilizing activity [GO:0140912]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060]; cell adhesion mediator activity [GO:0098631]; lipopolysaccharide binding [GO:0001530]; membrane destabilizing activity [GO:0140912]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; heterotypic cell-cell adhesion [GO:0034113]; killing of cells of another organism [GO:0031640]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; muscle cell differentiation [GO:0042692]; nervous system development [GO:0007399]; positive regulation of angiogenesis [GO:0045766]; positive regulation of inflammatory response [GO:0050729]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; programmed cell death [GO:0012501]; protein homooligomerization [GO:0051260]; pyroptosis [GO:0070269]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: [Ninjurin-1]: Cell membrane {ECO:0000269|PubMed:37198476}; Multi-pass membrane protein {ECO:0000269|PubMed:37198476}. Synaptic cell membrane {ECO:0000250|UniProtKB:O70131}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Secreted ninjurin-1]: Secreted {ECO:0000305|PubMed:32883094}.
Q92985	reviewed	IRF7_HUMAN	Interferon regulatory factor 7 (IRF-7)	IRF7	Homo sapiens (Human)	503	FUNCTION: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:28342865, PubMed:28768858). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045). {ECO:0000250|UniProtKB:P70434, ECO:0000269|PubMed:11073981, ECO:0000269|PubMed:12374802, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:17404045, ECO:0000269|PubMed:17574024, ECO:0000269|PubMed:28342865, ECO:0000269|PubMed:28768858, ECO:0000269|PubMed:32972995}.	MISCELLANEOUS: [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; establishment of viral latency [GO:0019043]; immune system process [GO:0002376]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of adaptive immune response [GO:0002819]; regulation of immune response [GO:0050776]; regulation of monocyte differentiation [GO:0045655]; regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034124]; regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034127]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type I interferon production [GO:0032479]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; establishment of viral latency [GO:0019043]; immune system process [GO:0002376]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of adaptive immune response [GO:0002819]; regulation of immune response [GO:0050776]; regulation of monocyte differentiation [GO:0045655]; regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034124]; regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034127]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type I interferon production [GO:0032479]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.
Q92988	reviewed	DLX4_HUMAN	Homeobox protein DLX-4 (Beta protein 1) (Homeobox protein DLX-7) (Homeobox protein DLX-8)	DLX4 BP1 DLX7 DLX8 DLX9	Homo sapiens (Human)	240	FUNCTION: May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis. {ECO:0000269|PubMed:11909945, ECO:0000269|PubMed:25954033}.		cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25954033}.
Q92989	reviewed	CLP1_HUMAN	Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1)	CLP1 HEAB	Homo sapiens (Human)	425	FUNCTION: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. {ECO:0000269|PubMed:17495927, ECO:0000269|PubMed:18648070, ECO:0000269|PubMed:24766809, ECO:0000269|PubMed:24766810}.		cerebellar cortex development [GO:0021695]; global gene silencing by mRNA cleavage [GO:0098795]; mRNA 3'-end processing [GO:0031124]; mRNA polyadenylation [GO:0006378]; phosphorylation [GO:0016310]; RISC complex assembly [GO:0070922]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	cytosol [GO:0005829]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-intron endonuclease complex [GO:0000214]	ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [GO:0051736]; polynucleotide 5'-hydroxyl-kinase activity [GO:0051731]	cytosol [GO:0005829]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-intron endonuclease complex [GO:0000214]; ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [GO:0051736]; polynucleotide 5'-hydroxyl-kinase activity [GO:0051731]; cerebellar cortex development [GO:0021695]; global gene silencing by mRNA cleavage [GO:0098795]; mRNA 3'-end processing [GO:0031124]; mRNA polyadenylation [GO:0006378]; phosphorylation [GO:0016310]; RISC complex assembly [GO:0070922]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035, ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:24766810}.
Q92990	reviewed	GLMN_HUMAN	Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein)	GLMN FAP48 FAP68 VMGLOM	Homo sapiens (Human)	594	FUNCTION: [Isoform 1]: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924). Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature (PubMed:11845407). Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281). {ECO:0000250|UniProtKB:Q8BZM1, ECO:0000269|PubMed:11571281, ECO:0000269|PubMed:11845407, ECO:0000269|PubMed:22405651, ECO:0000269|PubMed:22748924}.		cell surface receptor signaling pathway [GO:0007166]; epigenetic regulation of gene expression [GO:0040029]; muscle cell differentiation [GO:0042692]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of T cell proliferation [GO:0042130]; neural tube closure [GO:0001843]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of phosphorylation [GO:0042327]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; vasculogenesis [GO:0001570]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]	hepatocyte growth factor receptor binding [GO:0005171]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase inhibitor activity [GO:0055105]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; hepatocyte growth factor receptor binding [GO:0005171]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase inhibitor activity [GO:0055105]; cell surface receptor signaling pathway [GO:0007166]; epigenetic regulation of gene expression [GO:0040029]; muscle cell differentiation [GO:0042692]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of T cell proliferation [GO:0042130]; neural tube closure [GO:0001843]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of phosphorylation [GO:0042327]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; vasculogenesis [GO:0001570]	
Q92993	reviewed	KAT5_HUMAN	Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein)	KAT5 HTATIP TIP60	Homo sapiens (Human)	513	FUNCTION: Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:16387653, PubMed:19909775, PubMed:25865756, PubMed:27153538, PubMed:29335245, PubMed:29174981, PubMed:33076429, PubMed:32822602). Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270). The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17709392, PubMed:19783983, PubMed:32832608). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:27153538, PubMed:32832608). Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (PubMed:17709392, PubMed:26438602). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17360565, PubMed:17996965, PubMed:24835996, PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:30704899, PubMed:32034146, PubMed:32817552, PubMed:34077757). Directly acetylates and activates ATM (PubMed:16141325). Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (PubMed:32034146). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:17360565, PubMed:24835996). Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311). Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (PubMed:33938178). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (PubMed:32817552). Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:34077757). Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (PubMed:34077757). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation and 2-hydroxyisobutyrylation, respectively (PubMed:29192674, PubMed:34608293). Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:34608293). Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (PubMed:26829474). Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (PubMed:29040603). Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (PubMed:30409912). Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (PubMed:34608293). {ECO:0000250|UniProtKB:Q8CHK4, ECO:0000269|PubMed:12776177, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15121871, ECO:0000269|PubMed:15310756, ECO:0000269|PubMed:16141325, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19783983, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:29174981, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32822602, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:33076429, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:34608293}.		apoptotic process [GO:0006915]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; establishment of mitotic spindle orientation [GO:0000132]; innate immune response [GO:0045087]; lipid droplet disassembly [GO:1905691]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; nucleotide-excision repair [GO:0006289]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of autophagy [GO:0010508]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of innate immune response [GO:0045089]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of protein acetylation [GO:1901985]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of hematopoietic stem cell differentiation [GO:1902036]; response to ionizing radiation [GO:0010212]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; mitotic spindle pole [GO:0097431]; MSL complex [GO:0072487]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Piccolo NuA4 histone acetyltransferase complex [GO:0032777]; site of double-strand break [GO:0035861]; Swr1 complex [GO:0000812]; transcription regulator complex [GO:0005667]	acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone H2A acetyltransferase activity [GO:0043998]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K16 acetyltransferase activity [GO:0046972]; metal ion binding [GO:0046872]; peptide 2-hydroxyisobutyryltransferase activity [GO:0106226]; peptide butyryltransferase activity [GO:0140065]; peptide crotonyltransferase activity [GO:0140064]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; mitotic spindle pole [GO:0097431]; MSL complex [GO:0072487]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Piccolo NuA4 histone acetyltransferase complex [GO:0032777]; site of double-strand break [GO:0035861]; Swr1 complex [GO:0000812]; transcription regulator complex [GO:0005667]; acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone H2A acetyltransferase activity [GO:0043998]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K16 acetyltransferase activity [GO:0046972]; metal ion binding [GO:0046872]; peptide 2-hydroxyisobutyryltransferase activity [GO:0106226]; peptide butyryltransferase activity [GO:0140065]; peptide crotonyltransferase activity [GO:0140064]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; apoptotic process [GO:0006915]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; establishment of mitotic spindle orientation [GO:0000132]; innate immune response [GO:0045087]; lipid droplet disassembly [GO:1905691]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; nucleotide-excision repair [GO:0006289]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of autophagy [GO:0010508]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of innate immune response [GO:0045089]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of protein acetylation [GO:1901985]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of hematopoietic stem cell differentiation [GO:1902036]; response to ionizing radiation [GO:0010212]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11262386, ECO:0000269|PubMed:11416127, ECO:0000269|PubMed:12551922, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17704809, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:25301942, ECO:0000269|PubMed:33938178}. Chromosome {ECO:0000269|PubMed:25560918, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:33076429}. Cytoplasm {ECO:0000269|PubMed:25301942}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:26829474}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:34608293}. Nucleus, nucleolus {ECO:0000269|PubMed:16387653}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11262386}. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies (PubMed:11262386). Transiently localizes to kinetochores in early mitosis (PubMed:26829474). Localizes to spindle poles when chromosomes align during metaphase (PubMed:34608293). Localizes in the cytoplasm and nucleus of round spermatids (By similarity). {ECO:0000250|UniProtKB:Q8CHK4, ECO:0000269|PubMed:11262386, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:34608293}.
Q92994	reviewed	TF3B_HUMAN	Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2)	BRF1 BRF GTF3B TAF3B2 TAF3C	Homo sapiens (Human)	677	FUNCTION: General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.		DNA-templated transcription initiation [GO:0006352]; positive regulation of transcription by RNA polymerase III [GO:0045945]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; transcription preinitiation complex assembly [GO:0070897]; tRNA transcription [GO:0009304]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIIB complex [GO:0000126]; transcription preinitiation complex [GO:0097550]	metal ion binding [GO:0046872]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TBP-class protein binding [GO:0017025]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIIB complex [GO:0000126]; transcription preinitiation complex [GO:0097550]; metal ion binding [GO:0046872]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TBP-class protein binding [GO:0017025]; DNA-templated transcription initiation [GO:0006352]; positive regulation of transcription by RNA polymerase III [GO:0045945]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; transcription preinitiation complex assembly [GO:0070897]; tRNA transcription [GO:0009304]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q92995	reviewed	UBP13_HUMAN	Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13)	USP13 ISOT3	Homo sapiens (Human)	863	FUNCTION: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damage response (PubMed:21571647, PubMed:32772043, PubMed:33592542). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Alternatively, forms with NEDD4 a deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy (PubMed:32101753). Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Regulates the cell cycle progression by stabilizing cell cycle proteins such as SKP2 and AURKB (PubMed:32772043). In addition, plays an important role in maintaining genomic stability and in DNA replication checkpoint activation via regulation of RAP80 and TOPBP1 (PubMed:33592542). Deubiquitinates the multifunctional protein HMGB1 and subsequently drives its nucleocytoplasmic localization and its secretion (PubMed:36585612). Positively regulates type I and type II interferon signalings by deubiquitinating STAT1 but negatively regulates antiviral response by deubiquitinating STING1 (PubMed:23940278, PubMed:28534493). {ECO:0000269|PubMed:17653289, ECO:0000269|PubMed:21571647, ECO:0000269|PubMed:21659512, ECO:0000269|PubMed:21811243, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:22216260, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28534493, ECO:0000269|PubMed:32101753, ECO:0000269|PubMed:32772043, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:36585612}.		autophagy [GO:0006914]; cell population proliferation [GO:0008283]; maintenance of unfolded protein involved in ERAD pathway [GO:1904378]; melanocyte differentiation [GO:0030318]; positive regulation of ERAD pathway [GO:1904294]; protein K29-linked deubiquitination [GO:0035523]; protein K6-linked deubiquitination [GO:0044313]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; regulation of autophagy [GO:0010506]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	BAT3 complex binding [GO:1904288]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; BAT3 complex binding [GO:1904288]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]; zinc ion binding [GO:0008270]; autophagy [GO:0006914]; cell population proliferation [GO:0008283]; maintenance of unfolded protein involved in ERAD pathway [GO:1904378]; melanocyte differentiation [GO:0030318]; positive regulation of ERAD pathway [GO:1904294]; protein K29-linked deubiquitination [GO:0035523]; protein K6-linked deubiquitination [GO:0044313]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; regulation of autophagy [GO:0010506]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36585612}.
Q92997	reviewed	DVL3_HUMAN	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)	DVL3 KIAA0208	Homo sapiens (Human)	716	FUNCTION: Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}.		canonical Wnt signaling pathway [GO:0060070]; intracellular signal transduction [GO:0035556]; non-canonical Wnt signaling pathway [GO:0035567]; non-canonical Wnt signaling pathway via JNK cascade [GO:0038031]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of GTPase activity [GO:0043547]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of protein localization [GO:0032880]; response to xenobiotic stimulus [GO:0009410]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	chromatin [GO:0000785]; cytosol [GO:0005829]	beta-catenin binding [GO:0008013]; frizzled binding [GO:0005109]; protease binding [GO:0002020]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]	chromatin [GO:0000785]; cytosol [GO:0005829]; beta-catenin binding [GO:0008013]; frizzled binding [GO:0005109]; protease binding [GO:0002020]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; canonical Wnt signaling pathway [GO:0060070]; intracellular signal transduction [GO:0035556]; non-canonical Wnt signaling pathway [GO:0035567]; non-canonical Wnt signaling pathway via JNK cascade [GO:0038031]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of GTPase activity [GO:0043547]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of protein localization [GO:0032880]; response to xenobiotic stimulus [GO:0009410]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O14641}.
Q93008	reviewed	USP9X_HUMAN	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)	USP9X DFFRX FAM USP9	Homo sapiens (Human)	2554	FUNCTION: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (PubMed:19135894, PubMed:25944111, PubMed:18254724, PubMed:22371489, PubMed:29626158). May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin (PubMed:19135894, PubMed:25944111, PubMed:22371489, PubMed:18254724, PubMed:29626158). Specifically hydrolyzes 'Lys-63'-, 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains (PubMed:25944111, PubMed:18254724, PubMed:33378666). Essential component of TGF-beta/BMP signaling cascade (PubMed:19135894). Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 (PubMed:19135894). Deubiquitinates alkylation repair enzyme ALKBH3 (PubMed:25944111). OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembly (PubMed:33378666). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres (PubMed:16322459). Involved in axonal growth and neuronal cell migration (PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein BMAL1 via its deubiquitinating activity (PubMed:29626158). Acts as a regulator of peroxisome import by mediating deubiquitination of PEX5: specifically deubiquitinates PEX5 monoubiquitinated at 'Cys-11' following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle (PubMed:22371489). Deubiquitinates PEG10 (By similarity). {ECO:0000250|UniProtKB:P70398, ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:18254724, ECO:0000269|PubMed:19135894, ECO:0000269|PubMed:22371489, ECO:0000269|PubMed:24607389, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29626158, ECO:0000269|PubMed:33378666}.	MISCELLANEOUS: Escapes X-inactivation. {ECO:0000269|PubMed:8922996}.	amyloid fibril formation [GO:1990000]; axon extension [GO:0048675]; BMP signaling pathway [GO:0030509]; cell division [GO:0051301]; cell migration [GO:0016477]; chromosome segregation [GO:0007059]; female gamete generation [GO:0007292]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; positive regulation of DNA demethylation [GO:1901537]; positive regulation of protein binding [GO:0032092]; positive regulation of TORC2 signaling [GO:1904515]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein K63-linked deubiquitination [GO:0070536]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020]; nucleus [GO:0005634]	co-SMAD binding [GO:0070410]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020]; nucleus [GO:0005634]; co-SMAD binding [GO:0070410]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; amyloid fibril formation [GO:1990000]; axon extension [GO:0048675]; BMP signaling pathway [GO:0030509]; cell division [GO:0051301]; cell migration [GO:0016477]; chromosome segregation [GO:0007059]; female gamete generation [GO:0007292]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; positive regulation of DNA demethylation [GO:1901537]; positive regulation of protein binding [GO:0032092]; positive regulation of TORC2 signaling [GO:1904515]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein K63-linked deubiquitination [GO:0070536]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19135894, ECO:0000269|PubMed:26833328}. Cell projection, growth cone {ECO:0000269|PubMed:24607389}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:26833328}.
Q93009	reviewed	UBP7_HUMAN	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)	USP7 HAUSP	Homo sapiens (Human)	1102	FUNCTION: Hydrolase that deubiquitinates target proteins such as FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:35216969). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872, PubMed:26786098). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling (PubMed:26365382). It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1 (PubMed:26365382). Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling (PubMed:35216969). {ECO:0000269|PubMed:11923872, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:20153724, ECO:0000269|PubMed:20601937, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:22411829, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:26365382, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:26786098, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28655758, ECO:0000269|PubMed:35216969}.; FUNCTION: (Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. {ECO:0000269|PubMed:14506283, ECO:0000269|PubMed:16160161, ECO:0000269|PubMed:18590780}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus, the interaction with viral EBNA1 increases the association of USP7 with PML proteins, which is required for the polyubiquitylation and degradation of PML. {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761}.		disruption by symbiont of host cell PML body [GO:0075342]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of gene expression via CpG island methylation [GO:0044027]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of DNA demethylation [GO:1901537]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of protein stability [GO:0031647]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of telomere capping [GO:1904353]; rhythmic process [GO:0048511]; transcription-coupled nucleotide-excision repair [GO:0006283]	chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; p53 binding [GO:0002039]	chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; p53 binding [GO:0002039]; disruption by symbiont of host cell PML body [GO:0075342]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of gene expression via CpG island methylation [GO:0044027]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of DNA demethylation [GO:1901537]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of protein stability [GO:0031647]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of telomere capping [GO:1904353]; rhythmic process [GO:0048511]; transcription-coupled nucleotide-excision repair [GO:0006283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:26678539}. Cytoplasm {ECO:0000269|PubMed:25283148}. Nucleus, PML body {ECO:0000269|PubMed:9034339}. Chromosome {ECO:0000269|PubMed:20601937}. Note=Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.
Q93015	reviewed	NAA80_HUMAN	N-alpha-acetyltransferase 80 (HsNAAA80) (EC 2.3.1.-) (N-acetyltransferase 6) (Protein fusion-2) (Protein fus-2)	NAA80 FUS2 NAT6	Homo sapiens (Human)	286	FUNCTION: N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:30028079, PubMed:29581253). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:30028079, PubMed:29581253). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992). {ECO:0000269|PubMed:10644992, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29581307, ECO:0000269|PubMed:30028079}.		actin modification [GO:0030047]; N-terminal peptidyl-aspartic acid acetylation [GO:0017190]; N-terminal peptidyl-glutamic acid acetylation [GO:0018002]; protein acetylation [GO:0006473]; regulation of actin polymerization or depolymerization [GO:0008064]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	acetyl-CoA binding [GO:1905502]; N-acetyltransferase activity [GO:0008080]; peptide alpha-N-acetyltransferase activity [GO:0004596]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; acetyl-CoA binding [GO:1905502]; N-acetyltransferase activity [GO:0008080]; peptide alpha-N-acetyltransferase activity [GO:0004596]; actin modification [GO:0030047]; N-terminal peptidyl-aspartic acid acetylation [GO:0017190]; N-terminal peptidyl-glutamic acid acetylation [GO:0018002]; protein acetylation [GO:0006473]; regulation of actin polymerization or depolymerization [GO:0008064]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10644992, ECO:0000269|PubMed:30028079}.
Q93033	reviewed	IGSF2_HUMAN	Immunoglobulin superfamily member 2 (IgSF2) (Cell surface glycoprotein V7) (Glu-Trp-Ile EWI motif-containing protein 101) (EWI-101) (CD antigen CD101)	CD101 EWI101 IGSF2 V7	Homo sapiens (Human)	1021	FUNCTION: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. {ECO:0000269|PubMed:11093127, ECO:0000269|PubMed:15737213, ECO:0000269|PubMed:7722299, ECO:0000269|PubMed:9233604, ECO:0000269|PubMed:9389317, ECO:0000269|PubMed:9647226}.		cell surface receptor signaling pathway [GO:0007166]; positive regulation of myeloid leukocyte differentiation [GO:0002763]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of myeloid leukocyte differentiation [GO:0002763]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q93034	reviewed	CUL5_HUMAN	Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)	CUL5 VACM1	Homo sapiens (Human)	780	FUNCTION: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11384984, PubMed:15601820). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:11384984, PubMed:15601820). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component (PubMed:11384984, PubMed:15601820). ECS(SOCS1) seems to direct ubiquitination of JAK2 (PubMed:11384984). ECS(KLHDC1) complex is part of the DesCEND (destruction via C-end degrons) pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine (PubMed:32200094). As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). May form a cell surface vasopressin receptor (PubMed:9037604). {ECO:0000269|PubMed:11384984, ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:19920177, ECO:0000269|PubMed:32200094, ECO:0000269|PubMed:9037604}.; FUNCTION: (Microbial infection) Seems to be involved in proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. {ECO:0000269|PubMed:12186903}.		ERBB2 signaling pathway [GO:0038128]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; site of DNA damage [GO:0090734]	calcium channel activity [GO:0005262]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; site of DNA damage [GO:0090734]; calcium channel activity [GO:0005262]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ERBB2 signaling pathway [GO:0038128]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35633597}. Note=Localizes to sites of DNA damage in a UBAP2 and UBAP2L-dependent manner. {ECO:0000269|PubMed:35633597}.
Q93038	reviewed	TNR25_HUMAN	Tumor necrosis factor receptor superfamily member 25 (Apo-3) (Apoptosis-inducing receptor AIR) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death receptor 3) (Lymphocyte-associated receptor of death) (LARD) (Protein WSL) (Protein WSL-1)	TNFRSF25 APO3 DDR3 DR3 TNFRSF12 WSL WSL1 UNQ455/PRO779	Homo sapiens (Human)	417	FUNCTION: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. {ECO:0000269|PubMed:8875942, ECO:0000269|PubMed:8994832, ECO:0000269|PubMed:9052839}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 12]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]	cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]; tumor necrosis factor receptor activity [GO:0005031]	cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; tumor necrosis factor receptor activity [GO:0005031]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 9]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 11]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted.; SUBCELLULAR LOCATION: [Isoform 10]: Secreted.; SUBCELLULAR LOCATION: [Isoform 12]: Secreted.
Q93045	reviewed	STMN2_HUMAN	Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10)	STMN2 SCG10 SCGN10	Homo sapiens (Human)	179	FUNCTION: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}.		cellular response to nerve growth factor stimulus [GO:1990090]; microtubule depolymerization [GO:0007019]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of neuron projection development [GO:0010977]; neuron projection development [GO:0031175]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of neuron projection development [GO:0010976]; regulation of microtubule polymerization or depolymerization [GO:0031110]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]	calcium-dependent protein binding [GO:0048306]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; calcium-dependent protein binding [GO:0048306]; tubulin binding [GO:0015631]; cellular response to nerve growth factor stimulus [GO:1990090]; microtubule depolymerization [GO:0007019]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of neuron projection development [GO:0010977]; neuron projection development [GO:0031175]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of neuron projection development [GO:0010976]; regulation of microtubule polymerization or depolymerization [GO:0031110]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, growth cone. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon. Golgi apparatus. Endosome {ECO:0000250}. Cell projection, lamellipodium. Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia. {ECO:0000250}.
Q93050	reviewed	VPP1_HUMAN	V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)	ATP6V0A1 ATP6N1 ATP6N1A VPP1	Homo sapiens (Human)	837	FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles (PubMed:33065002, PubMed:34909687, PubMed:33833240). In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons (PubMed:33833240). {ECO:0000250|UniProtKB:P32563, ECO:0000250|UniProtKB:Q29466, ECO:0000269|PubMed:33065002, ECO:0000269|PubMed:33833240, ECO:0000269|PubMed:34909687}.		endosomal lumen acidification [GO:0048388]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; endosomal lumen acidification [GO:0048388]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P25286}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P25286}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}.
Q93052	reviewed	LPP_HUMAN	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma)	LPP	Homo sapiens (Human)	612	FUNCTION: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}.		cell-cell adhesion [GO:0098609]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	metal ion binding [GO:0046872]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; metal ion binding [GO:0046872]; cell-cell adhesion [GO:0098609]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cell junction. Cell membrane. Note=Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1.
Q93062	reviewed	RBPMS_HUMAN	RNA-binding protein with multiple splicing (RBP-MS) (Heart and RRM expressed sequence) (Hermes)	RBPMS HERMES	Homo sapiens (Human)	196	FUNCTION: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403). {ECO:0000269|PubMed:17099224, ECO:0000269|PubMed:26347403}.	MISCELLANEOUS: [Isoform A]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.	response to oxidative stress [GO:0006979]; RNA processing [GO:0006396]; SMAD protein signal transduction [GO:0060395]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]	mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; response to oxidative stress [GO:0006979]; RNA processing [GO:0006396]; SMAD protein signal transduction [GO:0060395]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17099224}. Cytoplasm {ECO:0000269|PubMed:17099224}. Cytoplasm, P-body {ECO:0000269|PubMed:26347403}. Note=Translocates into cytoplasmic stress granules that probably correspond to P-bodies in response to oxidative stress. {ECO:0000269|PubMed:26347403}.
Q93063	reviewed	EXT2_HUMAN	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2) (Putative tumor suppressor protein EXT2)	EXT2	Homo sapiens (Human)	718	FUNCTION: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:22660413}.		cellular response to fibroblast growth factor stimulus [GO:0044344]; chondrocyte differentiation [GO:0002062]; endochondral bone morphogenesis [GO:0060350]; fluid transport [GO:0042044]; gene expression [GO:0010467]; glycosaminoglycan biosynthetic process [GO:0006024]; heart contraction [GO:0060047]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; mesoderm formation [GO:0001707]; multicellular organismal-level water homeostasis [GO:0050891]; ossification [GO:0001503]; polysaccharide biosynthetic process [GO:0000271]; regulation of blood pressure [GO:0008217]; signal transduction [GO:0007165]; sodium ion homeostasis [GO:0055078]; sulfation [GO:0051923]; vasodilation [GO:0042311]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; UDP-N-acetylglucosamine transferase complex [GO:0043541]	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020]; glycosyltransferase activity [GO:0016757]; heparan sulfate N-acetylglucosaminyltransferase activity [GO:0042328]; metal ion binding [GO:0046872]; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509]; protein heterodimerization activity [GO:0046982]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; UDP-N-acetylglucosamine transferase complex [GO:0043541]; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020]; glycosyltransferase activity [GO:0016757]; heparan sulfate N-acetylglucosaminyltransferase activity [GO:0042328]; metal ion binding [GO:0046872]; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509]; protein heterodimerization activity [GO:0046982]; cellular response to fibroblast growth factor stimulus [GO:0044344]; chondrocyte differentiation [GO:0002062]; endochondral bone morphogenesis [GO:0060350]; fluid transport [GO:0042044]; gene expression [GO:0010467]; glycosaminoglycan biosynthetic process [GO:0006024]; heart contraction [GO:0060047]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; mesoderm formation [GO:0001707]; multicellular organismal-level water homeostasis [GO:0050891]; ossification [GO:0001503]; polysaccharide biosynthetic process [GO:0000271]; regulation of blood pressure [GO:0008217]; signal transduction [GO:0007165]; sodium ion homeostasis [GO:0055078]; sulfation [GO:0051923]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:35137078}; Single-pass type II membrane protein {ECO:0000255}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
Q93070	reviewed	NAR4_HUMAN	Ecto-ADP-ribosyltransferase 4 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 4) (ARTC4) (Dombrock blood group carrier molecule) (Mono(ADP-ribosyl)transferase 4) (NAD(P)(+)--arginine ADP-ribosyltransferase 4) (CD antigen CD297)	ART4 DO DOK1	Homo sapiens (Human)	314			arginine metabolic process [GO:0006525]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779]; arginine metabolic process [GO:0006525]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
Q93074	reviewed	MED12_HUMAN	Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)	MED12 ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230	Homo sapiens (Human)	2177	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}.		axis elongation involved in somitogenesis [GO:0090245]; embryonic brain development [GO:1990403]; embryonic neurocranium morphogenesis [GO:0048702]; endoderm development [GO:0007492]; heart development [GO:0007507]; neural tube closure [GO:0001843]; oligodendrocyte development [GO:0014003]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; post-anal tail morphogenesis [GO:0036342]; protein ubiquitination [GO:0016567]; Schwann cell development [GO:0014044]; somatic stem cell population maintenance [GO:0035019]; spinal cord development [GO:0021510]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	CKM complex [GO:1990508]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]	CKM complex [GO:1990508]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]; axis elongation involved in somitogenesis [GO:0090245]; embryonic brain development [GO:1990403]; embryonic neurocranium morphogenesis [GO:0048702]; endoderm development [GO:0007492]; heart development [GO:0007507]; neural tube closure [GO:0001843]; oligodendrocyte development [GO:0014003]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; post-anal tail morphogenesis [GO:0036342]; protein ubiquitination [GO:0016567]; Schwann cell development [GO:0014044]; somatic stem cell population maintenance [GO:0035019]; spinal cord development [GO:0021510]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q93077	reviewed	H2A1C_HUMAN	Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l)	H2AC6 H2AFL HIST1H2AC	Homo sapiens (Human)	130	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		negative regulation of cell population proliferation [GO:0008285]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; negative regulation of cell population proliferation [GO:0008285]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q93079	reviewed	H2B1H_HUMAN	Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j)	H2BC9 H2BFJ HIST1H2BH	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		nucleosome assembly [GO:0006334]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; protein heterodimerization activity [GO:0046982]; STAT family protein binding [GO:0097677]; structural constituent of chromatin [GO:0030527]; ubiquitin-like protein ligase binding [GO:0044389]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; protein heterodimerization activity [GO:0046982]; STAT family protein binding [GO:0097677]; structural constituent of chromatin [GO:0030527]; ubiquitin-like protein ligase binding [GO:0044389]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q93084	reviewed	AT2A3_HUMAN	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3)	ATP2A3	Homo sapiens (Human)	999	FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium ion transport from cytosol to endoplasmic reticulum [GO:1903515]; intracellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of receptor binding [GO:1900121]; regulation of cardiac conduction [GO:1903779]; transport across blood-brain barrier [GO:0150104]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]; organelle membrane [GO:0031090]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calcium-dependent ATPase activity [GO:0030899]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; transmembrane transporter binding [GO:0044325]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]; organelle membrane [GO:0031090]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calcium-dependent ATPase activity [GO:0030899]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; transmembrane transporter binding [GO:0044325]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium ion transport from cytosol to endoplasmic reticulum [GO:1903515]; intracellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of receptor binding [GO:1900121]; regulation of cardiac conduction [GO:1903779]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}.
Q93086	reviewed	P2RX5_HUMAN	P2X purinoceptor 5 (P2X5) (ATP receptor) (Purinergic receptor)	P2RX5 P2X5	Homo sapiens (Human)	422	FUNCTION: Receptor for ATP that acts as a ligand-gated ion channel.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	calcium ion transmembrane transport [GO:0070588]; nervous system development [GO:0007399]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; response to ATP [GO:0033198]; signal transduction [GO:0007165]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; monoatomic ion channel activity [GO:0005216]; purinergic nucleotide receptor activity [GO:0001614]; transmembrane signaling receptor activity [GO:0004888]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; monoatomic ion channel activity [GO:0005216]; purinergic nucleotide receptor activity [GO:0001614]; transmembrane signaling receptor activity [GO:0004888]; calcium ion transmembrane transport [GO:0070588]; nervous system development [GO:0007399]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; response to ATP [GO:0033198]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q93088	reviewed	BHMT1_HUMAN	Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5)	BHMT	Homo sapiens (Human)	406	FUNCTION: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. {ECO:0000269|PubMed:10529246, ECO:0000269|PubMed:8798461, ECO:0000269|PubMed:9681996}.		'de novo' L-methionine biosynthetic process [GO:0071266]; amino-acid betaine catabolic process [GO:0006579]; amino-acid betaine metabolic process [GO:0006577]; L-methionine salvage [GO:0071267]; protein methylation [GO:0006479]; regulation of homocysteine metabolic process [GO:0050666]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	betaine-homocysteine S-methyltransferase activity [GO:0047150]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; betaine-homocysteine S-methyltransferase activity [GO:0047150]; zinc ion binding [GO:0008270]; 'de novo' L-methionine biosynthetic process [GO:0071266]; amino-acid betaine catabolic process [GO:0006579]; amino-acid betaine metabolic process [GO:0006577]; L-methionine salvage [GO:0071267]; protein methylation [GO:0006479]; regulation of homocysteine metabolic process [GO:0050666]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O09171}. Nucleus {ECO:0000250|UniProtKB:O09171}. Note=Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress. {ECO:0000250|UniProtKB:O09171}.
Q93091	reviewed	RNAS6_HUMAN	Ribonuclease K6 (RNase K6) (EC 3.1.27.-)	RNASE6 RNS6	Homo sapiens (Human)	150	FUNCTION: Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:8836175, PubMed:27013146). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:27089320). {ECO:0000269|PubMed:25075772, ECO:0000269|PubMed:27013146, ECO:0000269|PubMed:27089320, ECO:0000269|PubMed:8836175}.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response [GO:0006952]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; RNA catabolic process [GO:0006401]	cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]	endonuclease activity [GO:0004519]; nucleic acid binding [GO:0003676]; RNA nuclease activity [GO:0004540]	cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; endonuclease activity [GO:0004519]; nucleic acid binding [GO:0003676]; RNA nuclease activity [GO:0004540]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response [GO:0006952]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; RNA catabolic process [GO:0006401]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25075772}. Lysosome {ECO:0000305|PubMed:25075772}. Cytoplasmic granule {ECO:0000269|PubMed:25075772}.
Q93096	reviewed	TP4A1_HUMAN	Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)	PTP4A1 PRL1 PTPCAAX1	Homo sapiens (Human)	173	FUNCTION: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. {ECO:0000269|PubMed:12235145, ECO:0000269|PubMed:12782572, ECO:0000269|PubMed:14643450}.		cell cycle [GO:0007049]; dephosphorylation [GO:0016311]; positive regulation of cell migration [GO:0030335]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; spindle [GO:0005819]	protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; spindle [GO:0005819]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cell cycle [GO:0007049]; dephosphorylation [GO:0016311]; positive regulation of cell migration [GO:0030335]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10940933, ECO:0000269|PubMed:15571731}; Lipid-anchor {ECO:0000269|PubMed:10940933, ECO:0000269|PubMed:12235145, ECO:0000269|PubMed:15571731}. Early endosome {ECO:0000269|PubMed:12235145}. Endoplasmic reticulum {ECO:0000269|PubMed:12235145}. Cytoplasm {ECO:0000269|PubMed:12235145}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:12235145}. Nucleus {ECO:0000250|UniProtKB:Q78EG7}. Note=And mitotic spindle. {ECO:0000269|PubMed:12235145}.
Q93097	reviewed	WNT2B_HUMAN	Protein Wnt-2b (Protein Wnt-13)	WNT2B WNT13	Homo sapiens (Human)	391	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development. {ECO:0000250|UniProtKB:O70283}.		canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to starvation [GO:0009267]; chondrocyte differentiation [GO:0002062]; cornea development in camera-type eye [GO:0061303]; forebrain regionalization [GO:0021871]; hematopoietic stem cell proliferation [GO:0071425]; iris morphogenesis [GO:0061072]; lens development in camera-type eye [GO:0002088]; lung induction [GO:0060492]; male gonad development [GO:0008584]; mesenchymal-epithelial cell signaling [GO:0060638]; neuron differentiation [GO:0030182]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to starvation [GO:0009267]; chondrocyte differentiation [GO:0002062]; cornea development in camera-type eye [GO:0061303]; forebrain regionalization [GO:0021871]; hematopoietic stem cell proliferation [GO:0071425]; iris morphogenesis [GO:0061072]; lens development in camera-type eye [GO:0002088]; lung induction [GO:0060492]; male gonad development [GO:0008584]; mesenchymal-epithelial cell signaling [GO:0060638]; neuron differentiation [GO:0030182]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
Q93098	reviewed	WNT8B_HUMAN	Protein Wnt-8b	WNT8B	Homo sapiens (Human)	351	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. {ECO:0000269|PubMed:9536085}.		canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; determination of dorsal identity [GO:0048263]; gastrulation [GO:0007369]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; response to estradiol [GO:0032355]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; determination of dorsal identity [GO:0048263]; gastrulation [GO:0007369]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; response to estradiol [GO:0032355]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q93099	reviewed	HGD_HUMAN	Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase)	HGD HGO	Homo sapiens (Human)	445	FUNCTION: Catalyzes the conversion of homogentisate to maleylacetoacetate. {ECO:0000269|PubMed:8782815}.		L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	homogentisate 1,2-dioxygenase activity [GO:0004411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; homogentisate 1,2-dioxygenase activity [GO:0004411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572]	
Q93100	reviewed	KPBB_HUMAN	Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta)	PHKB	Homo sapiens (Human)	1093	FUNCTION: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation.		generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]	cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]	cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q95460	reviewed	HMR1_HUMAN	Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)	MR1	Homo sapiens (Human)	341	FUNCTION: Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells (PubMed:23051753, PubMed:26795251, PubMed:12794138, PubMed:19416870, PubMed:22692454, PubMed:23846752). In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1-2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (PubMed:26795251, PubMed:24695216, PubMed:20581831). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (PubMed:24695216). May present microbial antigens to various TRAV1-2-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin (PubMed:27527800, PubMed:31113973). Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (PubMed:24695216, PubMed:27527800, PubMed:23846752). During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity). Acts as an immune sensor of cancer cell metabolome (PubMed:31959982). May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR consisting of TRAV38.2-DV8*TRAJ31 alpha chain paired with a TRBV25.1*TRBJ2.3 beta chain on a non-MAIT CD8-positive T cell clone (MC.7.G5), triggering T cell-mediated killing of a wide range of cancer cell types (PubMed:31959982). {ECO:0000250|UniProtKB:Q8HWB0, ECO:0000269|PubMed:12794138, ECO:0000269|PubMed:19416870, ECO:0000269|PubMed:20581831, ECO:0000269|PubMed:22692454, ECO:0000269|PubMed:23051753, ECO:0000269|PubMed:23846752, ECO:0000269|PubMed:24695216, ECO:0000269|PubMed:26795251, ECO:0000269|PubMed:27527800, ECO:0000269|PubMed:31113973, ECO:0000269|PubMed:31959982}.		antigen processing and presentation of exogenous antigen [GO:0019884]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of T cell mediated cytotoxicity directed against tumor cell target [GO:0002854]; T cell differentiation in thymus [GO:0033077]	early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; MHC class I protein complex [GO:0042612]; plasma membrane [GO:0005886]	beta-2-microglobulin binding [GO:0030881]; MHC class I receptor activity [GO:0032393]; T cell receptor binding [GO:0042608]	early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; MHC class I protein complex [GO:0042612]; plasma membrane [GO:0005886]; beta-2-microglobulin binding [GO:0030881]; MHC class I receptor activity [GO:0032393]; T cell receptor binding [GO:0042608]; antigen processing and presentation of exogenous antigen [GO:0019884]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of T cell mediated cytotoxicity directed against tumor cell target [GO:0002854]; T cell differentiation in thymus [GO:0033077]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12794138, ECO:0000269|PubMed:18068122, ECO:0000269|PubMed:27043408}; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18068122, ECO:0000269|PubMed:27043408}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:18068122}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:27043408}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:18068122, ECO:0000269|PubMed:27043408}; Single-pass type I membrane protein {ECO:0000255}. Note=In the absence of antigen remains within the endoplasmic reticulum where it acts as a metabolite sensor. Antigen binding triggers trafficking of the ternary complex to the plasma membrane. After presentation, most of these complexes are rapidly internalized and degraded via endocytosis. A small subset recycles via endosomes back to the plasma membrane and may thus acquire and present new antigens that do not efficiently reach the endoplasmic reticulum. {ECO:0000269|PubMed:27043408}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:23457030}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23457030}; Single-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:23457030}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23457030}; Single-pass membrane protein {ECO:0000255}. Note=The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway. {ECO:0000269|PubMed:23457030}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000303|PubMed:9780177}.
Q969D9	reviewed	TSLP_HUMAN	Thymic stromal lymphopoietin	TSLP	Homo sapiens (Human)	159	FUNCTION: [Isoform 1]: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. {ECO:0000269|PubMed:11418668, ECO:0000269|PubMed:11480573, ECO:0000269|PubMed:17242164}.; FUNCTION: [Isoform 2]: May act as an antimicrobial peptide in the oral cavity and on the skin. {ECO:0000269|PubMed:24850429}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine (C-C motif) ligand 1 production [GO:0071654]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell activation [GO:0033005]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; interleukin-7 receptor binding [GO:0005139]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; interleukin-7 receptor binding [GO:0005139]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine (C-C motif) ligand 1 production [GO:0071654]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell activation [GO:0033005]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11418668}.
Q969E2	reviewed	SCAM4_HUMAN	Secretory carrier-associated membrane protein 4 (Secretory carrier membrane protein 4)	SCAMP4	Homo sapiens (Human)	229	FUNCTION: Probably involved in membrane protein trafficking. {ECO:0000250}.		protein transport [GO:0015031]	recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]		recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q969E3	reviewed	UCN3_HUMAN	Urocortin-3 (Stresscopin) (Urocortin III) (Ucn III)	UCN3 SPC	Homo sapiens (Human)	161	FUNCTION: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; digestion [GO:0007586]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of insulin secretion [GO:0032024]; positive regulation of membrane potential [GO:0045838]; response to corticosterone [GO:0051412]; response to glucose [GO:0009749]; response to immobilization stress [GO:0035902]; response to starvation [GO:0042594]	axon terminus [GO:0043679]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; varicosity [GO:0043196]	corticotropin-releasing hormone receptor 2 binding [GO:0051431]; corticotropin-releasing hormone receptor binding [GO:0051429]; hormone activity [GO:0005179]	axon terminus [GO:0043679]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; varicosity [GO:0043196]; corticotropin-releasing hormone receptor 2 binding [GO:0051431]; corticotropin-releasing hormone receptor binding [GO:0051429]; hormone activity [GO:0005179]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; digestion [GO:0007586]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of insulin secretion [GO:0032024]; positive regulation of membrane potential [GO:0045838]; response to corticosterone [GO:0051412]; response to glucose [GO:0009749]; response to immobilization stress [GO:0035902]; response to starvation [GO:0042594]	SUBCELLULAR LOCATION: Secreted.
Q969E8	reviewed	TSR2_HUMAN	Pre-rRNA-processing protein TSR2 homolog	TSR2	Homo sapiens (Human)	191	FUNCTION: May be involved in 20S pre-rRNA processing. {ECO:0000305}.		maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	nucleus [GO:0005634]		nucleus [GO:0005634]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	
Q969F0	reviewed	FATE1_HUMAN	Fetal and adult testis-expressed transcript protein (Cancer/testis antigen 43) (CT43) (Tumor antigen BJ-HCC-2)	FATE1 FATE	Homo sapiens (Human)	183	FUNCTION: Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). {ECO:0000269|PubMed:27402544, ECO:0000305|PubMed:26567849}.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]	identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]; identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:26567849, ECO:0000269|PubMed:27402544}. Mitochondrion outer membrane {ECO:0000269|PubMed:27402544}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27402544}; Single-pass membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:27402544}. Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER. {ECO:0000269|PubMed:27402544}.
Q969F1	reviewed	TF3C6_HUMAN	General transcription factor 3C polypeptide 6 (Transcription factor IIIC 35 kDa subunit) (TFIIIC 35 kDa subunit) (TFIIIC35) (Transcription factor IIIC subunit 6)	GTF3C6 C6orf51 CDA020 NPD020	Homo sapiens (Human)	213	FUNCTION: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. {ECO:0000269|PubMed:17409385}.		5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; tRNA transcription by RNA polymerase III [GO:0042797]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]	DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]; DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; 5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; tRNA transcription by RNA polymerase III [GO:0042797]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17409385}.
Q969F2	reviewed	NKD2_HUMAN	Protein naked cuticle homolog 2 (Naked-2) (hNkd2)	NKD2	Homo sapiens (Human)	451	FUNCTION: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}.		exocytosis [GO:0006887]; Golgi vesicle fusion to target membrane [GO:0048210]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein processing [GO:0010954]; protein localization to plasma membrane [GO:0072659]; Wnt signaling pathway [GO:0016055]	basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; exocytic vesicle [GO:0070382]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; growth factor binding [GO:0019838]; molecular adaptor activity [GO:0060090]; myosin heavy chain binding [GO:0032036]; ubiquitin protein ligase binding [GO:0031625]	basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; exocytic vesicle [GO:0070382]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; growth factor binding [GO:0019838]; molecular adaptor activity [GO:0060090]; myosin heavy chain binding [GO:0032036]; ubiquitin protein ligase binding [GO:0031625]; exocytosis [GO:0006887]; Golgi vesicle fusion to target membrane [GO:0048210]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein processing [GO:0010954]; protein localization to plasma membrane [GO:0072659]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}. Cytoplasm {ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}. Cytoplasmic vesicle {ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}.
Q969F8	reviewed	KISSR_HUMAN	KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor)	KISS1R AXOR12 GPR54	Homo sapiens (Human)	398	FUNCTION: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. {ECO:0000269|PubMed:15020672}.		G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	cell surface [GO:0009986]; cilium [GO:0005929]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	cell surface [GO:0009986]; cilium [GO:0005929]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q969F9	reviewed	HPS3_HUMAN	BLOC-2 complex member HPS3 (Hermansky-Pudlak syndrome 3 protein)	HPS3	Homo sapiens (Human)	1004	FUNCTION: Involved in early stages of melanosome biogenesis and maturation. {ECO:0000250|UniProtKB:Q91VB4}.		intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; organelle organization [GO:0006996]; platelet dense granule organization [GO:0060155]	BLOC-2 complex [GO:0031084]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]		BLOC-2 complex [GO:0031084]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; organelle organization [GO:0006996]; platelet dense granule organization [GO:0060155]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q91VB4}. Cytoplasm, cytosol {ECO:0000269|PubMed:15030569}.
Q969G2	reviewed	LHX4_HUMAN	LIM/homeobox protein Lhx4 (LIM homeobox protein 4)	LHX4	Homo sapiens (Human)	390	FUNCTION: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250, ECO:0000269|PubMed:28473536}.		animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; medial motor column neuron differentiation [GO:0021526]; motor neuron axon guidance [GO:0008045]; negative regulation of apoptotic process [GO:0043066]; neuron differentiation [GO:0030182]; placenta development [GO:0001890]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; medial motor column neuron differentiation [GO:0021526]; motor neuron axon guidance [GO:0008045]; negative regulation of apoptotic process [GO:0043066]; neuron differentiation [GO:0030182]; placenta development [GO:0001890]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q969G3	reviewed	SMCE1_HUMAN	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57)	SMARCE1 BAF57	Homo sapiens (Human)	411	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. {ECO:0000250|UniProtKB:O54941, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.		chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; neurogenesis [GO:0022008]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; N-acetyltransferase activity [GO:0008080]; nuclear receptor binding [GO:0016922]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; N-acetyltransferase activity [GO:0008080]; nuclear receptor binding [GO:0016922]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; neurogenesis [GO:0022008]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:12192000}.
Q969G5	reviewed	CAVN3_HUMAN	Caveolae-associated protein 3 (Cavin-3) (Protein kinase C delta-binding protein) (Serum deprivation response factor-related gene product that binds to C-kinase) (hSRBC)	CAVIN3 PRKCDBP SRBC	Homo sapiens (Human)	261	FUNCTION: Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). {ECO:0000250|UniProtKB:Q91VJ2, ECO:0000250|UniProtKB:Q9Z1H9, ECO:0000269|PubMed:19262564}.		circadian regulation of gene expression [GO:0032922]; cortical actin cytoskeleton organization [GO:0030866]; negative regulation of fermentation [GO:1901003]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]	protein kinase C binding [GO:0005080]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; protein kinase C binding [GO:0005080]; circadian regulation of gene expression [GO:0032922]; cortical actin cytoskeleton organization [GO:0030866]; negative regulation of fermentation [GO:1901003]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q91VJ2}. Membrane, caveola {ECO:0000269|PubMed:19262564}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91VJ2}. Note=Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000269|PubMed:19262564}.
Q969G6	reviewed	RIFK_HUMAN	Riboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase)	RFK	Homo sapiens (Human)	155	FUNCTION: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. {ECO:0000269|PubMed:19641494}.		apoptotic process [GO:0006915]; flavin adenine dinucleotide biosynthetic process [GO:0072388]; FMN biosynthetic process [GO:0009398]; phosphorylation [GO:0016310]; positive regulation of NAD(P)H oxidase activity [GO:0033864]; reactive oxygen species metabolic process [GO:0072593]; riboflavin biosynthetic process [GO:0009231]; riboflavin metabolic process [GO:0006771]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; riboflavin kinase activity [GO:0008531]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; riboflavin kinase activity [GO:0008531]; apoptotic process [GO:0006915]; flavin adenine dinucleotide biosynthetic process [GO:0072388]; FMN biosynthetic process [GO:0009398]; phosphorylation [GO:0016310]; positive regulation of NAD(P)H oxidase activity [GO:0033864]; reactive oxygen species metabolic process [GO:0072593]; riboflavin biosynthetic process [GO:0009231]; riboflavin metabolic process [GO:0006771]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q969G9	reviewed	NKD1_HUMAN	Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1)	NKD1 NKD PP7246	Homo sapiens (Human)	470	FUNCTION: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}.		eye photoreceptor cell differentiation [GO:0001754]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of convergent extension involved in axis elongation [GO:1901233]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of non-canonical Wnt signaling pathway via JNK cascade [GO:1901231]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of cell migration involved in somitogenic axis elongation [GO:0090249]; somatic muscle development [GO:0007525]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein phosphatase type 2A complex [GO:0000159]	calcium ion binding [GO:0005509]; PDZ domain binding [GO:0030165]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein phosphatase type 2A complex [GO:0000159]; calcium ion binding [GO:0005509]; PDZ domain binding [GO:0030165]; eye photoreceptor cell differentiation [GO:0001754]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of convergent extension involved in axis elongation [GO:1901233]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of non-canonical Wnt signaling pathway via JNK cascade [GO:1901231]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of cell migration involved in somitogenic axis elongation [GO:0090249]; somatic muscle development [GO:0007525]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q969H0	reviewed	FBXW7_HUMAN	F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)	FBXW7 FBW7 FBX30 SEL10	Homo sapiens (Human)	707	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:22748924, PubMed:34741373, PubMed:17434132, PubMed:26976582, PubMed:28727686, PubMed:35395208). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (PubMed:22748924, PubMed:34741373, PubMed:26774286, PubMed:17434132, PubMed:26976582, PubMed:28727686). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, MLST8, RICTOR, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:29149593, PubMed:25775507, PubMed:28007894, PubMed:26976582, PubMed:28727686, PubMed:25897075, PubMed:34102342). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage (PubMed:26774286). The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining (PubMed:26774286). {ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:26976582, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:28007894, ECO:0000269|PubMed:28727686, ECO:0000269|PubMed:29149593, ECO:0000269|PubMed:34102342, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:35395208, ECO:0000305|PubMed:12354302}.		cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; lipid homeostasis [GO:0055088]; lung development [GO:0030324]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of osteoclast development [GO:2001205]; negative regulation of SREBP signaling pathway [GO:2000639]; negative regulation of triglyceride biosynthetic process [GO:0010868]; Notch signaling pathway [GO:0007219]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of circadian rhythm [GO:0042752]; regulation of lipid storage [GO:0010883]; regulation of protein localization [GO:0032880]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; sister chromatid cohesion [GO:0007062]; ubiquitin recycling [GO:0010992]; vasculature development [GO:0001944]; vasculogenesis [GO:0001570]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005]	cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; phosphothreonine residue binding [GO:0050816]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin binding [GO:0043130]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activator activity [GO:0097027]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005]; cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; phosphothreonine residue binding [GO:0050816]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin binding [GO:0043130]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activator activity [GO:0097027]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; lipid homeostasis [GO:0055088]; lung development [GO:0030324]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of osteoclast development [GO:2001205]; negative regulation of SREBP signaling pathway [GO:2000639]; negative regulation of triglyceride biosynthetic process [GO:0010868]; Notch signaling pathway [GO:0007219]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of circadian rhythm [GO:0042752]; regulation of lipid storage [GO:0010883]; regulation of protein localization [GO:0032880]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; sister chromatid cohesion [GO:0007062]; ubiquitin recycling [GO:0010992]; vasculature development [GO:0001944]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleoplasm {ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:28007894}. Chromosome {ECO:0000269|PubMed:26774286}. Note=Localizes to site of double-strand breaks following phosphorylation by ATM. {ECO:0000269|PubMed:26774286}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:28007894}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleolus {ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:28007894}.
Q969H4	reviewed	CNKR1_HUMAN	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like)	CNKSR1 CNK1	Homo sapiens (Human)	720	FUNCTION: May function as an adapter protein or regulator of Ras signaling pathways.		transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]	protein-macromolecule adaptor activity [GO:0030674]	cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; protein-macromolecule adaptor activity [GO:0030674]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q969H6	reviewed	POP5_HUMAN	Ribonuclease P/MRP protein subunit POP5 (hPop5)	POP5 AD-008 HSPC004 x0003	Homo sapiens (Human)	163	FUNCTION: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:11413139, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:11413139, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648}.	MISCELLANEOUS: The last C-terminal 19 amino acids are not required for complex association and RNase activity.	rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]	multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]	ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]	multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]; ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11413139}.
Q969H8	reviewed	MYDGF_HUMAN	Myeloid-derived growth factor (MYDGF)	MYDGF C19orf10	Homo sapiens (Human)	173	FUNCTION: Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518). {ECO:0000250|UniProtKB:Q9CPT4, ECO:0000269|PubMed:25581518}.		angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17362502, ECO:0000269|PubMed:25581518}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:17362502}. Endoplasmic reticulum {ECO:0000269|PubMed:29954947}. Golgi apparatus {ECO:0000269|PubMed:29954947}. Note=The C-terminal RTEL motif may provide retention in the endoplasmic reticulum. {ECO:0000269|PubMed:25581518, ECO:0000269|PubMed:29954947}.
Q969I6	reviewed	S38A4_HUMAN	Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3)	SLC38A4 ATA3 NAT3 SNAT4	Homo sapiens (Human)	547	FUNCTION: Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:11342143, PubMed:19015196, PubMed:33928121). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:11414754). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (PubMed:11414754, PubMed:33928121). {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:19015196, ECO:0000269|PubMed:33928121}.		amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; L-alanine import across plasma membrane [GO:1904273]; neutral amino acid transport [GO:0015804]	microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; neutral L-amino acid:sodium symporter activity [GO:0005295]	microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; neutral L-amino acid:sodium symporter activity [GO:0005295]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; L-alanine import across plasma membrane [GO:1904273]; neutral amino acid transport [GO:0015804]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}; Multi-pass membrane protein {ECO:0000269|PubMed:11414754}. Cell projection, microvillus membrane {ECO:0000269|PubMed:19015196}; Multi-pass membrane protein. Note=Microvillus membrane localization in placenta. {ECO:0000269|PubMed:19015196}.
Q969J2	reviewed	ZKSC4_HUMAN	Zinc finger protein with KRAB and SCAN domains 4 (P373c6.1) (Zinc finger protein 307) (Zinc finger protein 427)	ZKSCAN4 ZNF307 ZNF427	Homo sapiens (Human)	545	FUNCTION: May be involved in the transcriptional activation of MDM2 and EP300 genes. {ECO:0000269|PubMed:17910948}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187, ECO:0000269|PubMed:17910948}.
Q969J3	reviewed	BORC5_HUMAN	BLOC-1-related complex subunit 5 (Loss of heterozygosity 12 chromosomal region 1) (Myristoylated lysosomal protein) (Myrlysin)	BORCS5 LOH12CR1	Homo sapiens (Human)	196	FUNCTION: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility. {ECO:0000269|PubMed:25898167}.		lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; positive regulation of anterograde synaptic vesicle transport [GO:1903744]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]	BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]		BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; positive regulation of anterograde synaptic vesicle transport [GO:1903744]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:25898167}; Lipid-anchor {ECO:0000269|PubMed:25898167}; Cytoplasmic side {ECO:0000269|PubMed:25898167}.
Q969J5	reviewed	I22R2_HUMAN	Interleukin-22 receptor subunit alpha-2 (IL-22 receptor subunit alpha-2) (IL-22R-alpha-2) (IL-22RA2) (Cytokine receptor class-II member 10) (Cytokine receptor family 2 member 10) (CRF2-10) (Cytokine receptor family type 2, soluble 1) (CRF2-S1) (Interleukin-22-binding protein) (IL-22BP) (IL22BP) (ZcytoR16)	IL22RA2 UNQ5793/PRO19598/PRO19822	Homo sapiens (Human)	263	FUNCTION: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.; FUNCTION: Isoform 1 may play a role in establishing and maintaining successful pregnancy.		cytokine-mediated signaling pathway [GO:0019221]; negative regulation of inflammatory response [GO:0050728]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	interleukin-22 binding [GO:0042017]; interleukin-22 receptor activity [GO:0042018]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-22 binding [GO:0042017]; interleukin-22 receptor activity [GO:0042018]; cytokine-mediated signaling pathway [GO:0019221]; negative regulation of inflammatory response [GO:0050728]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12700595}.
Q969K3	reviewed	RNF34_HUMAN	E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34)	RNF34	Homo sapiens (Human)	372	FUNCTION: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:15897238, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:22064484, ECO:0000269|PubMed:25012219, ECO:0000269|Ref.13, ECO:0000303|PubMed:18382127}.		apoptotic process [GO:0006915]; cellular response to cold [GO:0070417]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of oxygen metabolic process [GO:2000374]; regulation of signal transduction by p53 class mediator [GO:1901796]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; p53 binding [GO:0002039]; phosphatidylinositol phosphate binding [GO:1901981]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; phosphatidylinositol phosphate binding [GO:1901981]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; cellular response to cold [GO:0070417]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of oxygen metabolic process [GO:2000374]; regulation of signal transduction by p53 class mediator [GO:1901796]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15069192}; Peripheral membrane protein {ECO:0000305}. Endomembrane system {ECO:0000250|UniProtKB:Q6AYH3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6AYH3}. Nucleus {ECO:0000269|PubMed:22064484}. Nucleus speckle {ECO:0000269|PubMed:12118383}. Cytoplasm, cytosol {ECO:0000269|PubMed:15069192}.
Q969K4	reviewed	ABTB1_HUMAN	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein)	ABTB1 BPOZ PP2259	Homo sapiens (Human)	478	FUNCTION: May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes. {ECO:0000269|PubMed:10891360, ECO:0000269|PubMed:11494141}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	translation elongation factor activity [GO:0003746]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; translation elongation factor activity [GO:0003746]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11494141}.
Q969K7	reviewed	TMM54_HUMAN	Transmembrane protein 54 (Beta-casein-like protein) (Protein CAC-1)	TMEM54 BCLP CAC1	Homo sapiens (Human)	222				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q969L2	reviewed	MAL2_HUMAN	Protein MAL2	MAL2	Homo sapiens (Human)	176	FUNCTION: Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. {ECO:0000269|PubMed:12370246}.		myelination [GO:0042552]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; synaptic vesicle membrane [GO:0030672]	structural constituent of myelin sheath [GO:0019911]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; synaptic vesicle membrane [GO:0030672]; structural constituent of myelin sheath [GO:0019911]; myelination [GO:0042552]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endomembrane system. Cytoplasm, perinuclear region. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized Hep-G2 cells, distributed to the perinuclear region.
Q969L4	reviewed	LSM10_HUMAN	U7 snRNA-associated Sm-like protein LSm10	LSM10	Homo sapiens (Human)	123	FUNCTION: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. {ECO:0000269|PubMed:16914750}.		mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; RNA splicing [GO:0008380]	Cajal body [GO:0015030]; cytoplasmic U snRNP body [GO:0071254]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; U7 snRNP [GO:0005683]	histone pre-mRNA DCP binding [GO:0071208]; U7 snRNA binding [GO:0071209]	Cajal body [GO:0015030]; cytoplasmic U snRNP body [GO:0071254]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; U7 snRNP [GO:0005683]; histone pre-mRNA DCP binding [GO:0071208]; U7 snRNA binding [GO:0071209]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11574479}.
Q969M3	reviewed	YIPF5_HUMAN	Protein YIPF5 (Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5) (Smooth muscle cell-associated protein 5) (SMAP-5) (YIP1 family member 5) (YPT-interacting protein 1 A)	YIPF5 FINGER5 YIP1A PP12723 SB140 UNQ3123/PRO10275	Homo sapiens (Human)	257	FUNCTION: Plays a role in transport between endoplasmic reticulum and Golgi. In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi (PubMed:33164986). {ECO:0000269|PubMed:11489904, ECO:0000269|PubMed:15611160, ECO:0000269|PubMed:33164986}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; insulin processing [GO:0030070]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; vesicle fusion with Golgi apparatus [GO:0048280]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]		COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; insulin processing [GO:0030070]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; vesicle fusion with Golgi apparatus [GO:0048280]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9EQQ2}; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle {ECO:0000250|UniProtKB:Q5XID0}. Note=Enriched at the endoplasmic reticulum exit sites (By similarity). Incorporated into COPII-coated vesicles (By similarity). {ECO:0000250|UniProtKB:Q5XID0, ECO:0000250|UniProtKB:Q9EQQ2}.
Q969M7	reviewed	UBE2F_HUMAN	NEDD8-conjugating enzyme UBE2F (EC 2.3.2.32) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F)	UBE2F NCE2	Homo sapiens (Human)	185	FUNCTION: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. {ECO:0000269|PubMed:19250909}.		post-translational protein modification [GO:0043687]; protein neddylation [GO:0045116]	cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; NEDD8 conjugating enzyme activity [GO:0061654]; NEDD8 ligase activity [GO:0061663]; NEDD8 transferase activity [GO:0019788]	cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; NEDD8 conjugating enzyme activity [GO:0061654]; NEDD8 ligase activity [GO:0061663]; NEDD8 transferase activity [GO:0019788]; post-translational protein modification [GO:0043687]; protein neddylation [GO:0045116]	
Q969N2	reviewed	PIGT_HUMAN	GPI transamidase component PIG-T (Phosphatidylinositol-glycan biosynthesis class T protein)	PIGT CGI-06 PSEC0163 UNQ716/PRO1379	Homo sapiens (Human)	578	FUNCTION: Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. {ECO:0000269|PubMed:11483512, ECO:0000269|PubMed:34576938}.	MISCELLANEOUS: [Isoform 3]: May be due to intron retention. {ECO:0000305}.	attachment of GPI anchor to protein [GO:0016255]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]		cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]; attachment of GPI anchor to protein [GO:0016255]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Single-pass type I membrane protein {ECO:0000269|PubMed:11483512}.
Q969P0	reviewed	IGSF8_HUMAN	Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)	IGSF8 CD81P3 EWI2 KCT4	Homo sapiens (Human)	613	FUNCTION: May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. {ECO:0000269|PubMed:11504738, ECO:0000269|PubMed:12750295, ECO:0000269|PubMed:12752121, ECO:0000269|PubMed:14662754, ECO:0000269|PubMed:15070678}.		cell motility [GO:0048870]; nervous system development [GO:0007399]; single fertilization [GO:0007338]; skeletal muscle tissue development [GO:0007519]	extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]		extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cell motility [GO:0048870]; nervous system development [GO:0007399]; single fertilization [GO:0007338]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein.
Q969P5	reviewed	FBX32_HUMAN	F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx)	FBXO32	Homo sapiens (Human)	355	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. {ECO:0000269|PubMed:15531760}.		cellular response to dexamethasone stimulus [GO:0071549]; protein ubiquitination [GO:0016567]; response to denervation involved in regulation of muscle adaptation [GO:0014894]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; Z disc [GO:0030018]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; Z disc [GO:0030018]; cellular response to dexamethasone stimulus [GO:0071549]; protein ubiquitination [GO:0016567]; response to denervation involved in regulation of muscle adaptation [GO:0014894]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22249105, ECO:0000269|PubMed:26768247}. Nucleus {ECO:0000269|PubMed:22249105}. Note=Shuttles between cytoplasm and the nucleus.
Q969P6	reviewed	TOP1M_HUMAN	DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1)	TOP1MT	Homo sapiens (Human)	601	FUNCTION: Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). {ECO:0000250, ECO:0000269|PubMed:11526219}.		DNA replication [GO:0006260]; DNA topological change [GO:0006265]	chromosome [GO:0005694]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]	chromosome [GO:0005694]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11526219}.
Q969Q1	reviewed	TRI63_HUMAN	E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)	TRIM63 IRF MURF1 RNF28 SMRZ	Homo sapiens (Human)	353	FUNCTION: E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. {ECO:0000269|PubMed:11927605, ECO:0000269|PubMed:18222470}.		muscle contraction [GO:0006936]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; protein ubiquitination [GO:0016567]; response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878]; response to glucocorticoid [GO:0051384]; response to interleukin-1 [GO:0070555]; signal transduction [GO:0007165]; skeletal muscle atrophy [GO:0014732]	cytoplasm [GO:0005737]; M band [GO:0031430]; microtubule [GO:0005874]; nucleus [GO:0005634]; Z disc [GO:0030018]	titin binding [GO:0031432]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; M band [GO:0031430]; microtubule [GO:0005874]; nucleus [GO:0005634]; Z disc [GO:0030018]; titin binding [GO:0031432]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; muscle contraction [GO:0006936]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; protein ubiquitination [GO:0016567]; response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878]; response to glucocorticoid [GO:0051384]; response to interleukin-1 [GO:0070555]; signal transduction [GO:0007165]; skeletal muscle atrophy [GO:0014732]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. {ECO:0000250}.
Q969Q5	reviewed	RAB24_HUMAN	Ras-related protein Rab-24	RAB24	Homo sapiens (Human)	203	FUNCTION: May be involved in autophagy-related processes. {ECO:0000250}.	MISCELLANEOUS: The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP (By similarity). {ECO:0000250}.	autophagy [GO:0006914]; intracellular protein transport [GO:0006886]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagy [GO:0006914]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10660536}. Membrane {ECO:0000269|PubMed:10660536}; Lipid-anchor {ECO:0000305}. Note=Only about 20-25% is recovered in the particulate fraction. {ECO:0000269|PubMed:10660536}.
Q969Q6	reviewed	P2R3C_HUMAN	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (Protein phosphatase subunit G5PR) (Rhabdomyosarcoma antigen MU-RMS-40.6A/6C)	PPP2R3C C14orf10 G5PR	Homo sapiens (Human)	453	FUNCTION: May regulate MCM3AP phosphorylation through phosphatase recruitment (By similarity). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex (PubMed:24333728). May play a role in the activation-induced cell death of B-cells (By similarity). {ECO:0000250|UniProtKB:Q9JK24, ECO:0000269|PubMed:24333728}.		B cell homeostasis [GO:0001782]; cortical cytoskeleton organization [GO:0030865]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of B cell differentiation [GO:0045579]; regulation of antimicrobial humoral response [GO:0002759]; regulation of dephosphorylation [GO:0035303]; regulation of mitochondrial depolarization [GO:0051900]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]	centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]	centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; B cell homeostasis [GO:0001782]; cortical cytoskeleton organization [GO:0030865]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of B cell differentiation [GO:0045579]; regulation of antimicrobial humoral response [GO:0002759]; regulation of dephosphorylation [GO:0035303]; regulation of mitochondrial depolarization [GO:0051900]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15820313}. Cytoplasm {ECO:0000269|PubMed:15820313}. Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. {ECO:0000269|PubMed:15820313}.
Q969R2	reviewed	OSBP2_HUMAN	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4)	OSBP2 KIAA1664 ORP4 OSBPL4	Homo sapiens (Human)	916	FUNCTION: Binds 7-ketocholesterol.		spermatid development [GO:0007286]	apical dendrite [GO:0097440]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; sterol transporter activity [GO:0015248]	apical dendrite [GO:0097440]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; sterol transporter activity [GO:0015248]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
Q969R5	reviewed	LMBL2_HUMAN	Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2)	L3MBTL2	Homo sapiens (Human)	705	FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. {ECO:0000269|PubMed:19233876}.		chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q969R8	reviewed	ITFG2_HUMAN	KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2)	ITFG2	Homo sapiens (Human)	447	FUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000269|PubMed:28199306}.		cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; germinal center B cell differentiation [GO:0002314]; negative regulation of TORC1 signaling [GO:1904262]; regulation of TOR signaling [GO:0032006]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; KICSTOR complex [GO:0140007]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; KICSTOR complex [GO:0140007]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; germinal center B cell differentiation [GO:0002314]; negative regulation of TORC1 signaling [GO:1904262]; regulation of TOR signaling [GO:0032006]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28199306}. Note=Localization to lysosomes is amino acid-independent. {ECO:0000269|PubMed:28199306}.
Q969S0	reviewed	S35B4_HUMAN	Nucleotide sugar transporter SLC35B4 (Solute carrier family 35 member B4) (UDP-xylose and UDP-N-acetylglucosamine transporter) (YEA4 homolog)	SLC35B4 YEA4 PSEC0055	Homo sapiens (Human)	331	FUNCTION: Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for another nucleotide sugar. May couple UDP-alpha-D-glucuronate (UDP-GlcA) or UDP-alpha-D-xylose (UDP-Xyl) efflux to UDP-alpha-D-glucuronate (UDP-GlcA) influx into the ER lumen, which in turn stimulates glucuronidation and excretion of endobiotics and xenobiotics. {ECO:0000269|PubMed:16965264, ECO:0000305|PubMed:15911612}.; FUNCTION: [Isoform 1]: Has UDP-GlcA:UDP-GlcNAc antiporter activity. {ECO:0000269|PubMed:16965264}.; FUNCTION: [Isoform 2]: Has UDP-GlcA:UDP-GlcNAc antiporter activity. {ECO:0000269|PubMed:16965264}.		carbohydrate transport [GO:0008643]; regulation of gluconeogenesis [GO:0006111]; UDP-N-acetylglucosamine transmembrane transport [GO:1990569]; UDP-xylose transmembrane transport [GO:0015790]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	UDP-N-acetylglucosamine transmembrane transporter activity [GO:0005462]; UDP-xylose transmembrane transporter activity [GO:0005464]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; UDP-N-acetylglucosamine transmembrane transporter activity [GO:0005462]; UDP-xylose transmembrane transporter activity [GO:0005464]; carbohydrate transport [GO:0008643]; regulation of gluconeogenesis [GO:0006111]; UDP-N-acetylglucosamine transmembrane transport [GO:1990569]; UDP-xylose transmembrane transport [GO:0015790]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30458018}; Multi-pass membrane protein {ECO:0000255}.
Q969S2	reviewed	NEIL2_HUMAN	Endonuclease 8-like 2 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (Endonuclease VIII-like 2) (Nei homolog 2) (NEH2) (Nei-like protein 2)	NEIL2	Homo sapiens (Human)	332	FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. {ECO:0000269|PubMed:12097317, ECO:0000269|PubMed:14522990, ECO:0000269|PubMed:15175427, ECO:0000269|PubMed:15339932}.		base-excision repair [GO:0006284]; depyrimidination [GO:0045008]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; microtubule binding [GO:0008017]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; microtubule binding [GO:0008017]; zinc ion binding [GO:0008270]; base-excision repair [GO:0006284]; depyrimidination [GO:0045008]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12097317}.
Q969S3	reviewed	ZN622_HUMAN	Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9)	ZNF622 ZPR9	Homo sapiens (Human)	477	FUNCTION: Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. {ECO:0000269|PubMed:33711283}.		intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; ribosomal large subunit biogenesis [GO:0042273]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]	preribosome binding [GO:1990275]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]; preribosome binding [GO:1990275]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; ribosomal large subunit biogenesis [GO:0042273]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11802789}. Nucleus {ECO:0000269|PubMed:11802789}.
Q969S6	reviewed	TM203_HUMAN	Transmembrane protein 203	TMEM203	Homo sapiens (Human)	136	FUNCTION: Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873). {ECO:0000269|PubMed:25996873}.		intracellular calcium ion homeostasis [GO:0006874]; spermatogenesis [GO:0007283]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular calcium ion homeostasis [GO:0006874]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25996873}; Multi-pass membrane protein {ECO:0000305}.
Q969S8	reviewed	HDA10_HUMAN	Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10)	HDAC10	Homo sapiens (Human)	669	FUNCTION: Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:21247901, ECO:0000269|PubMed:23801752, ECO:0000269|PubMed:26221039, ECO:0000269|PubMed:28516954, ECO:0000269|PubMed:29968769}.	MISCELLANEOUS: Like some other members of the HD type 2 subfamily, such as HDAC4, inhibited by the antitumor drug trichostatin A (TSA). {ECO:0000269|PubMed:11861901}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	chromatin organization [GO:0006325]; DNA repair [GO:0006281]; histone deacetylation [GO:0016575]; homologous recombination [GO:0035825]; macroautophagy [GO:0016236]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine deacetylation [GO:0034983]; polyamine deacetylation [GO:0106047]; positive regulation of mismatch repair [GO:0032425]; regulation of DNA-templated transcription [GO:0006355]; spermidine deacetylation [GO:0106048]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	acetylputrescine deacetylase activity [GO:0047609]; acetylspermidine deacetylase activity [GO:0047611]; deacetylase activity [GO:0019213]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; protein lysine deacetylase activity [GO:0033558]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; acetylputrescine deacetylase activity [GO:0047609]; acetylspermidine deacetylase activity [GO:0047611]; deacetylase activity [GO:0019213]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; protein lysine deacetylase activity [GO:0033558]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; DNA repair [GO:0006281]; histone deacetylation [GO:0016575]; homologous recombination [GO:0035825]; macroautophagy [GO:0016236]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine deacetylation [GO:0034983]; polyamine deacetylation [GO:0106047]; positive regulation of mismatch repair [GO:0032425]; regulation of DNA-templated transcription [GO:0006355]; spermidine deacetylation [GO:0106048]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:23801752}. Nucleus {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901}. Note=Excluded from nucleoli. {ECO:0000269|PubMed:11726666}.
Q969S9	reviewed	RRF2M_HUMAN	Ribosome-releasing factor 2, mitochondrial (RRF2mt) (EC 3.6.5.-) (Elongation factor G 2, mitochondrial) (EF-G2mt) (mEF-G 2) (Elongation factor G2) (hEFG2)	GFM2 EFG2 MSTP027	Homo sapiens (Human)	779	FUNCTION: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with MRRF (PubMed:19716793, PubMed:33878294). Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts (PubMed:33878294). GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit (PubMed:19716793). Not involved in the GTP-dependent ribosomal translocation step during translation elongation (PubMed:19716793). {ECO:0000269|PubMed:19716793, ECO:0000269|PubMed:33878294}.	MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted. {ECO:0000255|HAMAP-Rule:MF_03059}.	mitochondrial translation [GO:0032543]; mitochondrial translational termination [GO:0070126]; ribosome disassembly [GO:0032790]	mitochondrial matrix [GO:0005759]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	mitochondrial matrix [GO:0005759]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; mitochondrial translation [GO:0032543]; mitochondrial translational termination [GO:0070126]; ribosome disassembly [GO:0032790]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03059}.
Q969T4	reviewed	UB2E3_HUMAN	Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)	UBE2E3 UBCE4 UBCH9	Homo sapiens (Human)	207	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. {ECO:0000269|PubMed:10343118, ECO:0000269|PubMed:20061386}.		protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15545318}. Cytoplasm {ECO:0000269|PubMed:15545318}. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.
Q969T7	reviewed	5NT3B_HUMAN	7-methylguanosine phosphate-specific 5'-nucleotidase (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3B) (Cytosolic 5'-nucleotidase III-like protein) (cN-III-like protein) (EC 3.1.3.5) (N(7)-methylguanylate 5'-phosphatase)	NT5C3B NT5C3L	Homo sapiens (Human)	300	FUNCTION: Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233). {ECO:0000269|PubMed:23223233, ECO:0000269|PubMed:24603684}.		exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; nucleotide metabolic process [GO:0009117]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; nucleotide metabolic process [GO:0009117]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q969T9	reviewed	WBP2_HUMAN	WW domain-binding protein 2 (WBP-2)	WBP2	Homo sapiens (Human)	261	FUNCTION: Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Required for YAP1 coactivation function on PGR activity (PubMed:16772533). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity). {ECO:0000250|UniProtKB:P97765, ECO:0000269|PubMed:16772533}.		cellular response to estrogen stimulus [GO:0071391]; establishment of protein localization to chromatin [GO:0071169]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; response to estrogen [GO:0043627]; response to progesterone [GO:0032570]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; cellular response to estrogen stimulus [GO:0071391]; establishment of protein localization to chromatin [GO:0071169]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; response to estrogen [GO:0043627]; response to progesterone [GO:0032570]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21642474}. Nucleus {ECO:0000269|PubMed:21642474}. Note=Translocates from cytoplasm to nucleus when phosphorylated. {ECO:0000269|PubMed:21642474}.
Q969U6	reviewed	FBXW5_HUMAN	F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)	FBXW5 FBW5 PP3971	Homo sapiens (Human)	566	FUNCTION: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. {ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:19232515, ECO:0000269|PubMed:21725316}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	protein kinase binding [GO:0019901]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; protein kinase binding [GO:0019901]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21725316}.
Q969U7	reviewed	PSMG2_HUMAN	Proteasome assembly chaperone 2 (PAC-2) (Hepatocellular carcinoma-susceptibility protein 3) (Tumor necrosis factor superfamily member 5-induced protein 1)	PSMG2 HCCA3 PAC2 TNFSF5IP1	Homo sapiens (Human)	264	FUNCTION: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}.		chaperone-mediated protein complex assembly [GO:0051131]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; proteasome assembly [GO:0043248]	cytosol [GO:0005829]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]	molecular adaptor activity [GO:0060090]	cytosol [GO:0005829]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; molecular adaptor activity [GO:0060090]; chaperone-mediated protein complex assembly [GO:0051131]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; proteasome assembly [GO:0043248]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9EST4}.
Q969V3	reviewed	NCLN_HUMAN	BOS complex subunit NCLN (Nicalin) (Nicastrin-like protein)	NCLN	Homo sapiens (Human)	563	FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261522, PubMed:32820719). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity). {ECO:0000250|UniProtKB:Q6NZ07, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.		multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; protein stabilization [GO:0050821]; regulation of protein complex stability [GO:0061635]; regulation of protein-containing complex assembly [GO:0043254]; regulation of signal transduction [GO:0009966]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; multi-pass translocon complex [GO:0160064]; protein-containing complex [GO:0032991]	ribosome binding [GO:0043022]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; multi-pass translocon complex [GO:0160064]; protein-containing complex [GO:0032991]; ribosome binding [GO:0043022]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; protein stabilization [GO:0050821]; regulation of protein complex stability [GO:0061635]; regulation of protein-containing complex assembly [GO:0043254]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15257293, ECO:0000269|PubMed:20538592}; Single-pass membrane protein {ECO:0000269|PubMed:15257293, ECO:0000269|PubMed:20538592}.
Q969V4	reviewed	TEKT1_HUMAN	Tektin-1	TEKT1	Homo sapiens (Human)	418	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. {ECO:0000269|PubMed:36191189}.		cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]	axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; nucleus [GO:0005634]		axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; nucleus [GO:0005634]; cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q32KZ9}.
Q969V5	reviewed	MUL1_HUMAN	Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 2.3.2.27) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (Protein Hades) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) (RING-type E3 ubiquitin transferase NFKB 1)	MUL1 C1orf166 GIDE MAPL MULAN RNF218	Homo sapiens (Human)	352	FUNCTION: Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation (PubMed:22410793). Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion (PubMed:21597459). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response (PubMed:23399697). Can mediate RIGI sumoylation and disrupt its polyubiquitination (PubMed:23399697). {ECO:0000269|PubMed:18207745, ECO:0000269|PubMed:18213395, ECO:0000269|PubMed:18591963, ECO:0000269|PubMed:19407830, ECO:0000269|PubMed:22410793, ECO:0000269|PubMed:23399697, ECO:0000269|PubMed:24898855}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; mitochondrial fission [GO:0000266]; mitochondrion localization [GO:0051646]; negative regulation of cell growth [GO:0030308]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of defense response to virus by host [GO:0050689]; negative regulation of innate immune response [GO:0045824]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [GO:1904925]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of dendrite extension [GO:1903861]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein sumoylation [GO:0033235]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901028]; regulation of mitochondrion organization [GO:0010821]	axon [GO:0030424]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; peroxisome [GO:0005777]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	axon [GO:0030424]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; peroxisome [GO:0005777]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; mitochondrial fission [GO:0000266]; mitochondrion localization [GO:0051646]; negative regulation of cell growth [GO:0030308]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of defense response to virus by host [GO:0050689]; negative regulation of innate immune response [GO:0045824]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [GO:1904925]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of dendrite extension [GO:1903861]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein sumoylation [GO:0033235]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901028]; regulation of mitochondrion organization [GO:0010821]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18207745, ECO:0000269|PubMed:18213395, ECO:0000269|PubMed:18591963, ECO:0000269|PubMed:21597459}; Multi-pass membrane protein {ECO:0000255}. Peroxisome {ECO:0000269|PubMed:18207745}. Note=Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome. {ECO:0000269|PubMed:18207745}.
Q969V6	reviewed	MRTFA_HUMAN	Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein)	MRTFA KIAA1438 MAL MKL1	Homo sapiens (Human)	931	FUNCTION: Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}.		actin cytoskeleton organization [GO:0030036]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; smooth muscle cell differentiation [GO:0051145]; wound healing, spreading of cells [GO:0044319]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	actin binding [GO:0003779]; actin monomer binding [GO:0003785]; leucine zipper domain binding [GO:0043522]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; actin binding [GO:0003779]; actin monomer binding [GO:0003785]; leucine zipper domain binding [GO:0043522]; transcription coactivator activity [GO:0003713]; actin cytoskeleton organization [GO:0030036]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; smooth muscle cell differentiation [GO:0051145]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24440334}. Nucleus {ECO:0000269|PubMed:19350017, ECO:0000269|PubMed:24440334}. Note=Subcellular location is tightly regulated by actin both in cytoplasm and nucleus: high levels of G-actin in the nucleus observed during serum deprivation lead to low levels of nuclear MRTFA, while reduced levels of nuclear G-actin result in accumulation of MRTFA in the nucleus (By similarity). G-actin-binding in the cytoplasm inhibits nuclear import by masking the nuclear localization signal (NLS) (By similarity). In contrast, binding to nuclear globular actin (G-actin) promotes nuclear export to the cytoplasm (By similarity). Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear actin, which decreases nuclear G-actin pool, thereby promoting retention of MRTFA in the nucleus and subsequent formation of an active complex with SRF (PubMed:24440334). {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:24440334}.
Q969W0	reviewed	SPTSA_HUMAN	Serine palmitoyltransferase small subunit A (Small subunit of serine palmitoyltransferase A) (ssSPTa)	SPTSSA C14orf147 SSSPTA	Homo sapiens (Human)	71	FUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:19416851). The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core (PubMed:19416851). Within the SPT complex, SPTSSA stimulates the catalytic activity and plays a role in substrate specificity, which depends upon the overall complex composition (PubMed:19416851, PubMed:33558761). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19416851). Independently of its action as a SPT component, may be involved in MBOAT7 localization to mitochondria-associated membranes, a membrane bridge between the endoplasmic reticulum and mitochondria, may hence affect MBOAT7-catalyzed incorporation of arachidonic acid into phosphatidylinositol (PubMed:23510452). {ECO:0000269|PubMed:19416851, ECO:0000269|PubMed:23510452, ECO:0000269|PubMed:33558761}.		ceramide biosynthetic process [GO:0046513]; protein localization [GO:0008104]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; serine C-palmitoyltransferase complex [GO:0017059]	serine C-palmitoyltransferase activity [GO:0004758]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; serine C-palmitoyltransferase complex [GO:0017059]; serine C-palmitoyltransferase activity [GO:0004758]; ceramide biosynthetic process [GO:0046513]; protein localization [GO:0008104]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23510452}; Multi-pass membrane protein {ECO:0000255}.
Q969W1	reviewed	ZDH16_HUMAN	Palmitoyltransferase ZDHHC16 (EC 2.3.1.225) (Abl-philin 2) (Zinc finger DHHC domain-containing protein 16) (DHHC-16)	ZDHHC16 APH2 UNQ2570/PRO6258	Homo sapiens (Human)	377	FUNCTION: Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:28826475). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity). {ECO:0000250|UniProtKB:B8A4F0, ECO:0000250|UniProtKB:Q9ESG8, ECO:0000269|PubMed:28826475}.		apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; eye development [GO:0001654]; heart development [GO:0007507]; protein palmitoylation [GO:0018345]; telencephalon development [GO:0021537]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; eye development [GO:0001654]; heart development [GO:0007507]; protein palmitoylation [GO:0018345]; telencephalon development [GO:0021537]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17123647}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9ESG8}.
Q969W9	reviewed	PMEPA_HUMAN	Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein)	PMEPA1 STAG1 TMEPAI	Homo sapiens (Human)	287	FUNCTION: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}.		androgen receptor signaling pathway [GO:0030521]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]	protein sequestering activity [GO:0140311]; R-SMAD binding [GO:0070412]; WW domain binding [GO:0050699]	early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein sequestering activity [GO:0140311]; R-SMAD binding [GO:0070412]; WW domain binding [GO:0050699]; androgen receptor signaling pathway [GO:0030521]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	SUBCELLULAR LOCATION: Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Q969X0	reviewed	RIPL2_HUMAN	RILP-like protein 2 (Rab-interacting lysosomal protein-like 2) (p40phox-binding protein)	RILPL2 RLP2	Homo sapiens (Human)	211	FUNCTION: Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). May function via activation of RAC1 and PAK1 (By similarity). {ECO:0000250|UniProtKB:Q6AYA0, ECO:0000250|UniProtKB:Q99LE1}.		cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; protein transport from ciliary membrane to plasma membrane [GO:1903445]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267]; cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; protein transport from ciliary membrane to plasma membrane [GO:1903445]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:14668488}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
Q969X1	reviewed	LFG3_HUMAN	Protein lifeguard 3 (Protein RECS1 homolog) (Transmembrane BAX inhibitor motif-containing protein 1)	TMBIM1 LFG3 RECS1 PP1201 PSEC0158	Homo sapiens (Human)	311	FUNCTION: Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.		negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of catalytic activity [GO:0043086]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of Fas signaling pathway [GO:1902045]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of blood vessel remodeling [GO:2000504]	endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	death receptor binding [GO:0005123]	endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; death receptor binding [GO:0005123]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of catalytic activity [GO:0043086]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of Fas signaling pathway [GO:1902045]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of blood vessel remodeling [GO:2000504]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269|PubMed:16607040}. Endosome membrane {ECO:0000269|PubMed:16607040}.
Q969X2	reviewed	SIA7F_HUMAN	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (EC 2.4.99.-) (GalNAc alpha-2,6-sialyltransferase VI) (ST6GalNAc VI) (ST6GalNAcVI) (hST6GalNAc VI) (Sialyltransferase 7F) (SIAT7-F)	ST6GALNAC6 SIAT7F UNQ708/PRO1359	Homo sapiens (Human)	333	FUNCTION: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:12668675, PubMed:17123352). Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity). {ECO:0000250|UniProtKB:Q9JM95, ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:17123352}.	MISCELLANEOUS: The carbohydrate antigen disialyl Lewis a, which is at least partly synthesized by ST6GALNAC6, is a normal counterpart of sialyl Lewis a, better known as CA19-9, an antigen widely used as a serum marker for diagnosis of cancers in the digestive track. Disialyl Lewis a is predominantly expressed in non-malignant epithelial cells of the digestive organs, while sialyl Lewis a is preferentially expressed in cancers. Disialyl Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors, such as SIGLEC7 and SIGLEC9, expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes in digestive organs. Sialyl Lewis a, as well as its positional isomer sialyl Lewis x, serves as a ligand for vascular cell adhesion molecule E-selectin and facilitates hematogenous metastasis through mediating adhesion of circulating cancer cells to vascular endothelium (PubMed:17760270). {ECO:0000305|PubMed:17760270}.	cell-cell recognition [GO:0009988]; ganglioside biosynthetic process [GO:0001574]; glycoprotein metabolic process [GO:0009100]; glycosphingolipid metabolic process [GO:0006687]; glycosylceramide metabolic process [GO:0006677]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]	cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; sialyltransferase activity [GO:0008373]	cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; sialyltransferase activity [GO:0008373]; cell-cell recognition [GO:0009988]; ganglioside biosynthetic process [GO:0001574]; glycoprotein metabolic process [GO:0009100]; glycosphingolipid metabolic process [GO:0006687]; glycosylceramide metabolic process [GO:0006677]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q969X5	reviewed	ERGI1_HUMAN	Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ER-Golgi intermediate compartment 32 kDa protein) (ERGIC-32)	ERGIC1 ERGIC32 KIAA1181 HT034	Homo sapiens (Human)	290	FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000303|PubMed:15308636}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]		COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15308636}; Multi-pass membrane protein {ECO:0000269|PubMed:15308636}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:15308636}; Multi-pass membrane protein {ECO:0000269|PubMed:15308636}. Golgi apparatus membrane {ECO:0000269|PubMed:15308636}; Multi-pass membrane protein {ECO:0000269|PubMed:15308636}. Note=Cycles between the endoplasmic reticulum and the Golgi.
Q969X6	reviewed	UTP4_HUMAN	U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (UTP4 small subunit processome component)	UTP4 CIRH1A cPERP-E KIAA1988	Homo sapiens (Human)	686	FUNCTION: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted d Involved in SSU pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766, PubMed:34516797). May be a transcriptional regulator (PubMed:22916032). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:19732766, ECO:0000269|PubMed:22916032, ECO:0000269|PubMed:34516797}.; FUNCTION: (Microbial infection) Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV. {ECO:0000269|PubMed:19732766}.	MISCELLANEOUS: [Isoform 3]: May be due to intron retention. {ECO:0000305}.	maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of DNA-templated transcription [GO:0006355]; ribosomal small subunit biogenesis [GO:0042274]	90S preribosome [GO:0030686]; chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455]	RNA binding [GO:0003723]	90S preribosome [GO:0030686]; chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455]; RNA binding [GO:0003723]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of DNA-templated transcription [GO:0006355]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16225863, ECO:0000269|PubMed:24219289, ECO:0000269|PubMed:34516797}. Chromosome {ECO:0000269|PubMed:20813266}. Note=Found predominantly at the fibrillar center. {ECO:0000269|PubMed:24219289}.
Q969Y2	reviewed	GTPB3_HUMAN	tRNA modification GTPase GTPBP3, mitochondrial (GTP-binding protein 3) (Mitochondrial GTP-binding protein 1)	GTPBP3 MTGP1	Homo sapiens (Human)	492	FUNCTION: GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. {ECO:0000305}.		tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12370316}.
Q969Z0	reviewed	FAKD4_HUMAN	FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4)	TBRG4 CPR2 FASTKD4 KIAA0948	Homo sapiens (Human)	631	FUNCTION: Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed:9383053). {ECO:0000269|PubMed:28335001, ECO:0000269|PubMed:9383053}.		mitochondrial mRNA processing [GO:0090615]; mitochondrial RNA processing [GO:0000963]; mRNA metabolic process [GO:0016071]; positive regulation of cell population proliferation [GO:0008284]; regulation of cell cycle [GO:0051726]; regulation of mitochondrial mRNA stability [GO:0044528]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]	RNA binding [GO:0003723]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]; RNA binding [GO:0003723]; mitochondrial mRNA processing [GO:0090615]; mitochondrial RNA processing [GO:0000963]; mRNA metabolic process [GO:0016071]; positive regulation of cell population proliferation [GO:0008284]; regulation of cell cycle [GO:0051726]; regulation of mitochondrial mRNA stability [GO:0044528]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:28335001}.
Q969Z3	reviewed	MARC2_HUMAN	Mitochondrial amidoxime reducing component 2 (mARC2) (EC 1.7.-.-) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 2) (MOSC domain-containing protein 2) (Moco sulfurase C-terminal domain-containing protein 2)	MTARC2 MARC2 MOSC2	Homo sapiens (Human)	335	FUNCTION: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:21029045, PubMed:24423752). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045). {ECO:0000269|PubMed:21029045, ECO:0000269|PubMed:24423752}.		cellular detoxification of nitrogen compound [GO:0070458]; detoxification of nitrogen compound [GO:0051410]; nitrate metabolic process [GO:0042126]; nitric oxide biosynthetic process [GO:0006809]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]	molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940]; nitrite reductase activity [GO:0098809]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; pyridoxal phosphate binding [GO:0030170]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940]; nitrite reductase activity [GO:0098809]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; pyridoxal phosphate binding [GO:0030170]; cellular detoxification of nitrogen compound [GO:0070458]; detoxification of nitrogen compound [GO:0051410]; nitrate metabolic process [GO:0042126]; nitric oxide biosynthetic process [GO:0006809]	SUBCELLULAR LOCATION: Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome {ECO:0000250}.
Q969Z4	reviewed	TR19L_HUMAN	Tumor necrosis factor receptor superfamily member 19L (Receptor expressed in lymphoid tissues)	RELT TNFRSF19L	Homo sapiens (Human)	430	FUNCTION: May play a role in apoptosis (PubMed:28688764, PubMed:19969290). Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727). Involved in dental enamel formation (PubMed:30506946). {ECO:0000269|PubMed:16530727, ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:30506946}.		amelogenesis [GO:0097186]; apoptotic process [GO:0006915]	nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]		nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; amelogenesis [GO:0097186]; apoptotic process [GO:0006915]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16389068}; Single-pass type I membrane protein {ECO:0000269|PubMed:16389068}. Cytoplasm {ECO:0000269|PubMed:16389068}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:22052202}.
Q96A08	reviewed	H2B1A_HUMAN	Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)	H2BC1 HIST1H2BA TSH2B	Homo sapiens (Human)	127	FUNCTION: Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133). {ECO:0000250|UniProtKB:P70696, ECO:0000269|PubMed:21249133}.		chromosome organization [GO:0051276]; inflammatory response [GO:0006954]; mononuclear cell migration [GO:0071674]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; plasminogen activation [GO:0031639]; sperm DNA condensation [GO:0035092]	cell surface [GO:0009986]; chromosome, telomeric region [GO:0000781]; female germ cell nucleus [GO:0001674]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone binding [GO:0042393]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	cell surface [GO:0009986]; chromosome, telomeric region [GO:0000781]; female germ cell nucleus [GO:0001674]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone binding [GO:0042393]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; chromosome organization [GO:0051276]; inflammatory response [GO:0006954]; mononuclear cell migration [GO:0071674]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; plasminogen activation [GO:0031639]; sperm DNA condensation [GO:0035092]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P70696}. Chromosome {ECO:0000250|UniProtKB:P70696}.
Q96A09	reviewed	TET5B_HUMAN	Terminal nucleotidyltransferase 5B (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46B)	TENT5B FAM46B	Homo sapiens (Human)	425	FUNCTION: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner (PubMed:32009146, PubMed:34048638). May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs (PubMed:32009146). Prefers RNA molecules that are adenosine-rich close to 3'-end (PubMed:32009146). In addition, may inhibit cell proliferation and cell cycle progression through ubiquitination of beta-catenin/CTNNB1 (PubMed:30532005). {ECO:0000269|PubMed:30532005, ECO:0000269|PubMed:32009146, ECO:0000269|PubMed:34048638}.		mRNA stabilization [GO:0048255]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of translation [GO:0045727]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	poly(A) RNA polymerase activity [GO:1990817]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; poly(A) RNA polymerase activity [GO:1990817]; mRNA stabilization [GO:0048255]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of translation [GO:0045727]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32009146}. Nucleus {ECO:0000269|PubMed:32009146}.
Q96A11	reviewed	G3ST3_HUMAN	Galactose-3-O-sulfotransferase 3 (Gal3ST-3) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 3) (Gal3ST3) (Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3)	GAL3ST3	Homo sapiens (Human)	431	FUNCTION: Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc. {ECO:0000269|PubMed:11323440, ECO:0000269|PubMed:11356829}.		glycolipid biosynthetic process [GO:0009247]; monosaccharide metabolic process [GO:0005996]; oligosaccharide metabolic process [GO:0009311]; poly-N-acetyllactosamine metabolic process [GO:0030309]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790]	Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]	3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; carbohydrate binding [GO:0030246]; galactose 3-O-sulfotransferase activity [GO:0050694]; galactosylceramide sulfotransferase activity [GO:0001733]; proteoglycan sulfotransferase activity [GO:0050698]	Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]; 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; carbohydrate binding [GO:0030246]; galactose 3-O-sulfotransferase activity [GO:0050694]; galactosylceramide sulfotransferase activity [GO:0001733]; proteoglycan sulfotransferase activity [GO:0050698]; glycolipid biosynthetic process [GO:0009247]; monosaccharide metabolic process [GO:0005996]; oligosaccharide metabolic process [GO:0009311]; poly-N-acetyllactosamine metabolic process [GO:0030309]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q96A25	reviewed	T106A_HUMAN	Transmembrane protein 106A	TMEM106A	Homo sapiens (Human)	262	FUNCTION: Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (PubMed:30456879, PubMed:29131025). {ECO:0000250|UniProtKB:Q8VC04, ECO:0000269|PubMed:29131025, ECO:0000269|PubMed:30456879}.		CD80 biosynthetic process [GO:0035780]; CD86 biosynthetic process [GO:0035781]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of nitric oxide metabolic process [GO:1904407]; positive regulation of tumor necrosis factor production [GO:0032760]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; CD80 biosynthetic process [GO:0035780]; CD86 biosynthetic process [GO:0035781]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of nitric oxide metabolic process [GO:1904407]; positive regulation of tumor necrosis factor production [GO:0032760]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VC04}; Single-pass membrane protein {ECO:0000255}.
Q96A26	reviewed	F162A_HUMAN	Protein FAM162A (E2-induced gene 5 protein) (Growth and transformation-dependent protein) (HGTD-P)	FAM162A C3orf28 E2IG5 DC16 FWP001	Homo sapiens (Human)	154	FUNCTION: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity). {ECO:0000250|UniProtKB:Q9D6U8, ECO:0000269|PubMed:15082785}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cellular response to hypoxia [GO:0071456]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]	cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cellular response to hypoxia [GO:0071456]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:15082785, ECO:0000269|PubMed:16698020}; Single-pass membrane protein {ECO:0000305}.
Q96A29	reviewed	FUCT1_HUMAN	GDP-fucose transporter 1 (Solute carrier family 35 member C1)	SLC35C1 FUCT1	Homo sapiens (Human)	364	FUNCTION: Antiporter specific for GDP-l-fucose and depending on the concomitant reverse transport of GMP. Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. {ECO:0000269|PubMed:11326279, ECO:0000269|PubMed:11326280, ECO:0000269|PubMed:27738779}.		carbohydrate transport [GO:0008643]; GDP-fucose import into Golgi lumen [GO:0036085]; lipid glycosylation [GO:0030259]; negative regulation of Notch signaling pathway [GO:0045746]; protein O-linked fucosylation [GO:0036066]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	antiporter activity [GO:0015297]; GDP-fucose transmembrane transporter activity [GO:0005457]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; antiporter activity [GO:0015297]; GDP-fucose transmembrane transporter activity [GO:0005457]; carbohydrate transport [GO:0008643]; GDP-fucose import into Golgi lumen [GO:0036085]; lipid glycosylation [GO:0030259]; negative regulation of Notch signaling pathway [GO:0045746]; protein O-linked fucosylation [GO:0036066]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:11326279, ECO:0000305|PubMed:11326280, ECO:0000305|PubMed:27738779}; Multi-pass membrane protein {ECO:0000255}.
Q96A32	reviewed	MYL11_HUMAN	Myosin regulatory light chain 11 (Fast skeletal myosin light chain 2) (MLC2B) (Myosin light chain 11) (Myosin regulatory light chain 2, skeletal muscle isoform)	MYL11 HSRLC MYLPF	Homo sapiens (Human)	169	FUNCTION: Myosin regulatory subunit that plays an essential role to maintain muscle integrity during early development (By similarity). Plays a role in muscle contraction (By similarity). {ECO:0000250|UniProtKB:O93409}.		actin-myosin filament sliding [GO:0033275]; immune response [GO:0006955]; muscle contraction [GO:0006936]; muscle tissue morphogenesis [GO:0060415]; skeletal muscle tissue development [GO:0007519]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; muscle myosin complex [GO:0005859]	calcium ion binding [GO:0005509]; structural constituent of muscle [GO:0008307]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; muscle myosin complex [GO:0005859]; calcium ion binding [GO:0005509]; structural constituent of muscle [GO:0008307]; actin-myosin filament sliding [GO:0033275]; immune response [GO:0006955]; muscle contraction [GO:0006936]; muscle tissue morphogenesis [GO:0060415]; skeletal muscle tissue development [GO:0007519]	
Q96A33	reviewed	CCD47_HUMAN	PAT complex subunit CCDC47 (Calumin) (Coiled-coil domain-containing protein 47)	CCDC47 GK001 MSTP041 PSEC0077	Homo sapiens (Human)	483	FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32814900, PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity). Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex (By similarity). Involved in the regulation of calcium ion homeostasis in the ER (PubMed:30401460). Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (PubMed:25009997). Has an essential role in the maintenance of ER organization during embryogenesis (By similarity). {ECO:0000250|UniProtKB:A0A8I3P7X4, ECO:0000250|UniProtKB:Q9D024, ECO:0000269|PubMed:25009997, ECO:0000269|PubMed:30401460, ECO:0000269|PubMed:32814900, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.		endoplasmic reticulum calcium ion homeostasis [GO:0032469]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; osteoblast differentiation [GO:0001649]; post-embryonic development [GO:0009791]; protein insertion into ER membrane [GO:0045048]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; multi-pass translocon complex [GO:0160064]; protein folding chaperone complex [GO:0101031]; rough endoplasmic reticulum membrane [GO:0030867]	calcium ion binding [GO:0005509]; protein folding chaperone [GO:0044183]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; multi-pass translocon complex [GO:0160064]; protein folding chaperone complex [GO:0101031]; rough endoplasmic reticulum membrane [GO:0030867]; calcium ion binding [GO:0005509]; protein folding chaperone [GO:0044183]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; osteoblast differentiation [GO:0001649]; post-embryonic development [GO:0009791]; protein insertion into ER membrane [GO:0045048]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25009997, ECO:0000269|PubMed:30401460, ECO:0000269|PubMed:32814900}; Single-pass type I membrane protein {ECO:0000255}. Rough endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D024}; Single-pass type I membrane protein {ECO:0000255}.
Q96A37	reviewed	RN166_HUMAN	E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166)	RNF166	Homo sapiens (Human)	237	FUNCTION: E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896). In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896). Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228). Also plays a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896). Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896). {ECO:0000269|PubMed:26456228, ECO:0000269|PubMed:27880896}.		autophagy [GO:0006914]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; autophagy [GO:0006914]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26456228}.
Q96A44	reviewed	SPSB4_HUMAN	SPRY domain-containing SOCS box protein 4 (SSB-4)	SPSB4 SSB4	Homo sapiens (Human)	273	FUNCTION: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:21199876, ECO:0000269|PubMed:26392558, ECO:0000269|PubMed:28931592}.		intracellular signal transduction [GO:0035556]; positive regulation of protein polyubiquitination [GO:1902916]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; intracellular signal transduction [GO:0035556]; positive regulation of protein polyubiquitination [GO:1902916]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:21199876}. Note=Exhibits a diffuse cytosolic localization. {ECO:0000269|PubMed:21199876}.
Q96A49	reviewed	SYAP1_HUMAN	Synapse-associated protein 1 (BSD domain-containing signal transducer and Akt interactor protein) (BSTA)	SYAP1 PRO3113	Homo sapiens (Human)	352	FUNCTION: Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {ECO:0000269|PubMed:23300339}.		cell differentiation [GO:0030154]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to insulin stimulus [GO:0032869]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; TORC2 signaling [GO:0038203]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]		axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; cell differentiation [GO:0030154]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to insulin stimulus [GO:0032869]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; TORC2 signaling [GO:0038203]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9D5V6}. Golgi apparatus {ECO:0000250|UniProtKB:Q9D5V6}. Perikaryon {ECO:0000250|UniProtKB:Q9D5V6}. Cell projection, axon {ECO:0000250|UniProtKB:Q9D5V6}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9D5V6}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9D5V6}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9D5V6}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9D5V6}. Membrane {ECO:0000269|PubMed:23300339}. Note=Localizes to cholinergic neuromuscular junctions and in actin-rich growth cone regions (By similarity). Membrane-associated in a epidermal growth factor (EGF)-dependent manner (PubMed:23300339). {ECO:0000250|UniProtKB:Q9D5V6, ECO:0000269|PubMed:23300339}.
Q96A54	reviewed	PAQR1_HUMAN	Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member 1) (Progestin and adipoQ receptor family member I)	ADIPOR1 PAQR1 TESBP1A CGI-45	Homo sapiens (Human)	375	FUNCTION: Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity). {ECO:0000250|UniProtKB:Q91VH1, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}.		adiponectin-activated signaling pathway [GO:0033211]; fatty acid oxidation [GO:0019395]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; leptin-mediated signaling pathway [GO:0033210]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid metabolic process [GO:0019216]	membrane [GO:0016020]; plasma membrane [GO:0005886]	adipokinetic hormone receptor activity [GO:0097003]; adiponectin binding [GO:0055100]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; signaling receptor activity [GO:0038023]	membrane [GO:0016020]; plasma membrane [GO:0005886]; adipokinetic hormone receptor activity [GO:0097003]; adiponectin binding [GO:0055100]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; signaling receptor activity [GO:0038023]; adiponectin-activated signaling pathway [GO:0033211]; fatty acid oxidation [GO:0019395]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; leptin-mediated signaling pathway [GO:0033210]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid metabolic process [GO:0019216]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}; Multi-pass membrane protein {ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}. Note=Localized to the cell membrane and intracellular organelles. {ECO:0000269|PubMed:12802337}.
Q96A56	reviewed	T53I1_HUMAN	Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1)	TP53INP1 P53DINP1 SIP	Homo sapiens (Human)	240	FUNCTION: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. {ECO:0000269|PubMed:11511362, ECO:0000269|PubMed:22421968, ECO:0000269|PubMed:22470510}.		apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; autophagosome assembly [GO:0000045]; cellular response to ethanol [GO:0071361]; cellular response to hydroperoxide [GO:0071447]; cellular response to methyl methanesulfonate [GO:0072703]; cellular response to UV [GO:0034644]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of myofibroblast differentiation [GO:1904761]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of cell cycle [GO:0051726]; response to heat [GO:0009408]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	antioxidant activity [GO:0016209]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; antioxidant activity [GO:0016209]; apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; autophagosome assembly [GO:0000045]; cellular response to ethanol [GO:0071361]; cellular response to hydroperoxide [GO:0071447]; cellular response to methyl methanesulfonate [GO:0072703]; cellular response to UV [GO:0034644]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of myofibroblast differentiation [GO:1904761]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of cell cycle [GO:0051726]; response to heat [GO:0009408]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
Q96A57	reviewed	TM230_HUMAN	Transmembrane protein 230	TMEM230 C20orf30 HSPC274 UNQ2432/PRO4992	Homo sapiens (Human)	120	FUNCTION: Involved in trafficking and recycling of synaptic vesicles. {ECO:0000269|PubMed:27270108}.		synaptic vesicle transport [GO:0048489]	autophagosome [GO:0005776]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; late endosome [GO:0005770]; membrane [GO:0016020]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]		autophagosome [GO:0005776]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; late endosome [GO:0005770]; membrane [GO:0016020]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; synaptic vesicle transport [GO:0048489]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:27270108}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:27270108}. Early endosome {ECO:0000269|PubMed:27270108}. Recycling endosome {ECO:0000269|PubMed:27270108}. Late endosome {ECO:0000269|PubMed:27270108}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:27270108}.
Q96A58	reviewed	RERG_HUMAN	Ras-related and estrogen-regulated growth inhibitor (EC 3.6.5.2)	RERG	Homo sapiens (Human)	199	FUNCTION: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. {ECO:0000269|PubMed:11533059}.		negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; response to hormone [GO:0009725]; small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; nuclear estrogen receptor binding [GO:0030331]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; nuclear estrogen receptor binding [GO:0030331]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; response to hormone [GO:0009725]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11533059}.
Q96A59	reviewed	MALD3_HUMAN	MARVEL domain-containing protein 3	MARVELD3 MRVLDC3	Homo sapiens (Human)	401	FUNCTION: As a component of tight junctions, plays a role in paracellular ion conductivity. {ECO:0000269|PubMed:20028514}.		bicellular tight junction assembly [GO:0070830]; cell-cell junction organization [GO:0045216]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of JNK cascade [GO:0046329]; protein localization to cell junction [GO:1902414]; protein ubiquitination [GO:0016567]; response to osmotic stress [GO:0006970]; ubiquitin-dependent protein catabolic process [GO:0006511]	bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; nucleus [GO:0005634]	mitogen-activated protein kinase kinase kinase binding [GO:0031435]; ubiquitin protein ligase activity [GO:0061630]	bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; nucleus [GO:0005634]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; ubiquitin protein ligase activity [GO:0061630]; bicellular tight junction assembly [GO:0070830]; cell-cell junction organization [GO:0045216]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of JNK cascade [GO:0046329]; protein localization to cell junction [GO:1902414]; protein ubiquitination [GO:0016567]; response to osmotic stress [GO:0006970]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000269|PubMed:20028514}.
Q96A61	reviewed	TRI52_HUMAN	E3 ubiquitin-protein ligase TRIM52 (EC 2.3.2.27) (RING finger protein 102) (Tripartite motif-containing protein 52)	TRIM52 RNF102	Homo sapiens (Human)	297	FUNCTION: E3 ubiquitin-protein ligase (PubMed:27667714). Positively regulates the NF-kappa-B signaling pathway (PubMed:27667714, PubMed:28073078). {ECO:0000269|PubMed:27667714, ECO:0000269|PubMed:28073078}.; FUNCTION: (Microbial infection) Exhibits antiviral activity against Japanese encephalitis virus (JEV). Ubiquitinates the viral non-structural protein 2 (NS2A) and targets it for proteasome-mediated degradation. {ECO:0000269|PubMed:27667714}.	MISCELLANEOUS: Arose via a partial duplication of the TRIM41 gene, followed by independent loss or pseudogenization of TRIM52 in multiple mammalian and primate lineages. {ECO:0000305|PubMed:24158625}.	defense response to virus [GO:0051607]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; defense response to virus [GO:0051607]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28073078}. Cytoplasm, cytosol {ECO:0000269|PubMed:27667714}. Nucleus {ECO:0000269|PubMed:27667714, ECO:0000269|PubMed:28073078}.
Q96A65	reviewed	EXOC4_HUMAN	Exocyst complex component 4 (Exocyst complex component Sec8)	EXOC4 KIAA1699 SEC8 SEC8L1	Homo sapiens (Human)	974	FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}.		chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; paraxial mesoderm formation [GO:0048341]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone membrane [GO:0032584]; membrane [GO:0016020]; microvillus [GO:0005902]; myelin sheath abaxonal region [GO:0035748]; plasma membrane [GO:0005886]; synapse [GO:0045202]	PDZ domain binding [GO:0030165]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone membrane [GO:0032584]; membrane [GO:0016020]; microvillus [GO:0005902]; myelin sheath abaxonal region [GO:0035748]; plasma membrane [GO:0005886]; synapse [GO:0045202]; PDZ domain binding [GO:0030165]; chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; paraxial mesoderm formation [GO:0048341]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	SUBCELLULAR LOCATION: Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Cell projection {ECO:0000250|UniProtKB:Q62824}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26638075}. Note=Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). Localizes at the leading edge of migrating cells (By similarity). {ECO:0000250|UniProtKB:Q62824, ECO:0000269|PubMed:16213214}.
Q96A70	reviewed	AZIN2_HUMAN	Antizyme inhibitor 2 (AzI2) (Arginine decarboxylase) (ADC) (ARGDC) (Ornithine decarboxylase-like protein) (ODC-like protein) (ornithine decarboxylase paralog) (ODC-p)	AZIN2 ADC KIAA1945 ODCP	Homo sapiens (Human)	460	FUNCTION: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728). {ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:20188728}.		agmatine biosynthetic process [GO:0097055]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of catalytic activity [GO:0043085]; positive regulation of polyamine transmembrane transport [GO:1902269]; putrescine biosynthetic process from ornithine [GO:0033387]; spermatogenesis [GO:0007283]; trans-Golgi network membrane organization [GO:0098629]	axon [GO:0030424]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; granular vesicle [GO:1990005]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]	arginine decarboxylase activity [GO:0008792]; ornithine decarboxylase activator activity [GO:0042978]	axon [GO:0030424]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; granular vesicle [GO:1990005]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]; arginine decarboxylase activity [GO:0008792]; ornithine decarboxylase activator activity [GO:0042978]; agmatine biosynthetic process [GO:0097055]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of catalytic activity [GO:0043085]; positive regulation of polyamine transmembrane transport [GO:1902269]; putrescine biosynthetic process from ornithine [GO:0033387]; spermatogenesis [GO:0007283]; trans-Golgi network membrane organization [GO:0098629]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region. Membrane {ECO:0000250}. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Golgi apparatus, cis-Golgi network {ECO:0000250}. Golgi apparatus, trans-Golgi network. Cytoplasmic granule. Cell projection, axon. Cell projection, dendrite. Perikaryon. Note=Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in an antizyme-dependent manner. Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules (By similarity). Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules. {ECO:0000250}.
Q96A72	reviewed	MGN2_HUMAN	Protein mago nashi homolog 2	MAGOHB MAGOH2	Homo sapiens (Human)	148	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961, PubMed:30705154). Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022). {ECO:0000269|PubMed:23917022, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:30705154}.		mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of mRNA processing [GO:0050684]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; RNA splicing [GO:0008380]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; exon-exon junction subcomplex mago-y14 [GO:1990501]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; exon-exon junction subcomplex mago-y14 [GO:1990501]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of mRNA processing [GO:0050684]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:30705154}.
Q96A83	reviewed	COQA1_HUMAN	Collagen alpha-1(XXVI) chain (Alpha-1 type XXVI collagen) (EMI domain-containing protein 2) (Emilin and multimerin domain-containing protein 2) (Emu2)	COL26A1 EMID2 EMU2	Homo sapiens (Human)	441		MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site. {ECO:0000305}.	positive regulation of cell-substrate adhesion [GO:0010811]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]		collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; positive regulation of cell-substrate adhesion [GO:0010811]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q96AA3	reviewed	RFT1_HUMAN	Protein RFT1 homolog	RFT1	Homo sapiens (Human)	541	FUNCTION: May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane. {ECO:0000269|PubMed:18313027}.		carbohydrate transport [GO:0008643]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; glycolipid translocation [GO:0034203]	endoplasmic reticulum membrane [GO:0005789]	glycolipid floppase activity [GO:0034202]	endoplasmic reticulum membrane [GO:0005789]; glycolipid floppase activity [GO:0034202]; carbohydrate transport [GO:0008643]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; glycolipid translocation [GO:0034203]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96AA8	reviewed	JKIP2_HUMAN	Janus kinase and microtubule-interacting protein 2 (CTCL tumor antigen HD-CL-04) (Neuroendocrine long coiled-coil protein 1)	JAKMIP2 JAMIP2 KIAA0555 NECC1	Homo sapiens (Human)	810				Golgi apparatus [GO:0005794]	kinase binding [GO:0019900]; microtubule binding [GO:0008017]	Golgi apparatus [GO:0005794]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:17572408}.
Q96AB6	reviewed	NTAN1_HUMAN	Protein N-terminal asparagine amidohydrolase (EC 3.5.1.121) (Protein NH2-terminal asparagine amidohydrolase) (PNAA) (Protein NH2-terminal asparagine deamidase) (PNAD) (Protein N-terminal Asn amidase) (Protein N-terminal asparagine amidase) (Protein NTN-amidase)	NTAN1	Homo sapiens (Human)	310	FUNCTION: N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn. {ECO:0000269|PubMed:21375249}.		adult locomotory behavior [GO:0008344]; memory [GO:0007613]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	protein-N-terminal asparagine amidohydrolase activity [GO:0008418]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-N-terminal asparagine amidohydrolase activity [GO:0008418]; adult locomotory behavior [GO:0008344]; memory [GO:0007613]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q28955}.
Q96AC1	reviewed	FERM2_HUMAN	Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)	FERMT2 KIND2 MIG2 PLEKHC1	Homo sapiens (Human)	680	FUNCTION: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}.	MISCELLANEOUS: [Isoform 2]: May be due to an exon inclusion and an intron retention. {ECO:0000305}.	adherens junction maintenance [GO:0034334]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; focal adhesion assembly [GO:0048041]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; limb development [GO:0060173]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of vascular permeability [GO:0043116]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of integrin activation [GO:0033625]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of myosin light chain kinase activity [GO:0035505]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; protein localization to cell junction [GO:1902414]; protein localization to membrane [GO:0072657]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway [GO:0016055]	adherens junction [GO:0005912]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; I band [GO:0031674]; lamellipodium membrane [GO:0031258]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; integrin binding [GO:0005178]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; SMAD binding [GO:0046332]; type I transforming growth factor beta receptor binding [GO:0034713]	adherens junction [GO:0005912]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; I band [GO:0031674]; lamellipodium membrane [GO:0031258]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; integrin binding [GO:0005178]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; SMAD binding [GO:0046332]; type I transforming growth factor beta receptor binding [GO:0034713]; adherens junction maintenance [GO:0034334]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; focal adhesion assembly [GO:0048041]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; limb development [GO:0060173]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of vascular permeability [GO:0043116]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of integrin activation [GO:0033625]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of myosin light chain kinase activity [GO:0035505]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; protein localization to cell junction [GO:1902414]; protein localization to membrane [GO:0072657]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cell surface {ECO:0000250}. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.
Q96AD5	reviewed	PLPL2_HUMAN	Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2)	PNPLA2 ATGL FP17548	Homo sapiens (Human)	504	FUNCTION: Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674, PubMed:15364929, PubMed:16150821, PubMed:17603008, PubMed:16239926, PubMed:34903883). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17032652, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed:35676490). {ECO:0000250|UniProtKB:Q8BJ56, ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16239926, ECO:0000269|PubMed:17032652, ECO:0000269|PubMed:17603008, ECO:0000269|PubMed:34903883, ECO:0000269|PubMed:35676490}.		acylglycerol acyl-chain remodeling [GO:0036155]; diacylglycerol biosynthetic process [GO:0006651]; lipid droplet disassembly [GO:1905691]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; negative regulation of sequestering of triglyceride [GO:0010891]; positive regulation of triglyceride catabolic process [GO:0010898]; triglyceride catabolic process [GO:0019433]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	acylglycerol O-acyltransferase activity [GO:0016411]; diolein transacylation activity [GO:0051265]; lipoprotein lipase activity [GO:0004465]; mono-olein transacylation activity [GO:0051264]; phospholipase A2 activity [GO:0004623]; retinyl-palmitate esterase activity [GO:0050253]; triglyceride lipase activity [GO:0004806]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; acylglycerol O-acyltransferase activity [GO:0016411]; diolein transacylation activity [GO:0051265]; lipoprotein lipase activity [GO:0004465]; mono-olein transacylation activity [GO:0051264]; phospholipase A2 activity [GO:0004623]; retinyl-palmitate esterase activity [GO:0050253]; triglyceride lipase activity [GO:0004806]; acylglycerol acyl-chain remodeling [GO:0036155]; diacylglycerol biosynthetic process [GO:0006651]; lipid droplet disassembly [GO:1905691]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; negative regulation of sequestering of triglyceride [GO:0010891]; positive regulation of triglyceride catabolic process [GO:0010898]; triglyceride catabolic process [GO:0019433]	SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:16239926, ECO:0000269|PubMed:34903883}. Cell membrane {ECO:0000269|PubMed:17032652}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8BJ56}.
Q96AE4	reviewed	FUBP1_HUMAN	Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V)	FUBP1	Homo sapiens (Human)	644	FUNCTION: Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}.		positive regulation of gene expression [GO:0010628]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; positive regulation of gene expression [GO:0010628]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96AE7	reviewed	TTC17_HUMAN	Tetratricopeptide repeat protein 17 (TPR repeat protein 17)	TTC17	Homo sapiens (Human)	1141	FUNCTION: Plays a role in primary ciliogenesis by modulating actin polymerization. {ECO:0000269|PubMed:24475127}.		actin filament polymerization [GO:0030041]; cilium organization [GO:0044782]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]		actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; actin filament polymerization [GO:0030041]; cilium organization [GO:0044782]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24475127}. Cell membrane {ECO:0000269|PubMed:24475127}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24475127}. Note=Colocalized with CATIP at F-actin rich zones and at dynamic plasma membrane protrusions.
Q96AG3	reviewed	S2546_HUMAN	Mitochondrial outer membrane protein SLC25A46 (Solute carrier family 25 member 46)	SLC25A46 TB1	Homo sapiens (Human)	418	FUNCTION: Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization (PubMed:26168012, PubMed:27543974, PubMed:27390132). May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane (PubMed:27390132). Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission (PubMed:27390132). {ECO:0000269|PubMed:26168012, ECO:0000269|PubMed:27390132, ECO:0000269|PubMed:27543974}.		autophagy of mitochondrion [GO:0000422]; axon development [GO:0061564]; cerebellar Purkinje cell differentiation [GO:0021702]; cristae formation [GO:0042407]; dendrite development [GO:0016358]; locomotion involved in locomotory behavior [GO:0031987]; mitochondrial fission [GO:0000266]; mitochondrial membrane fission [GO:0090149]; mitochondrial transport [GO:0006839]; myelination in peripheral nervous system [GO:0022011]; optic nerve development [GO:0021554]; peripheral nervous system neuron axonogenesis [GO:0048936]; phospholipid homeostasis [GO:0055091]; protein-containing complex assembly [GO:0065003]; respiratory chain complex IV assembly [GO:0008535]; synapse assembly [GO:0007416]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	protein-containing complex binding [GO:0044877]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein-containing complex binding [GO:0044877]; autophagy of mitochondrion [GO:0000422]; axon development [GO:0061564]; cerebellar Purkinje cell differentiation [GO:0021702]; cristae formation [GO:0042407]; dendrite development [GO:0016358]; locomotion involved in locomotory behavior [GO:0031987]; mitochondrial fission [GO:0000266]; mitochondrial membrane fission [GO:0090149]; mitochondrial transport [GO:0006839]; myelination in peripheral nervous system [GO:0022011]; optic nerve development [GO:0021554]; peripheral nervous system neuron axonogenesis [GO:0048936]; phospholipid homeostasis [GO:0055091]; protein-containing complex assembly [GO:0065003]; respiratory chain complex IV assembly [GO:0008535]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:26168012, ECO:0000269|PubMed:27390132, ECO:0000269|PubMed:27543974}; Multi-pass membrane protein {ECO:0000255}.
Q96AG4	reviewed	LRC59_HUMAN	Leucine-rich repeat-containing protein 59 (Ribosome-binding protein p34) (p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed]	LRRC59 PRO1855	Homo sapiens (Human)	307	FUNCTION: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. {ECO:0000269|PubMed:22321063}.		signal transduction [GO:0007165]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial nucleoid [GO:0042645]; nuclear envelope [GO:0005635]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial nucleoid [GO:0042645]; nuclear envelope [GO:0005635]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.
Q96AH0	reviewed	SOSB2_HUMAN	SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) (hSSB2)	NABP1 OBFC2A SSB2	Homo sapiens (Human)	204	FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic G2/M transition checkpoint [GO:0044818]; response to ionizing radiation [GO:0010212]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876]	DNA binding [GO:0003677]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic G2/M transition checkpoint [GO:0044818]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage.
Q96AH8	reviewed	RAB7B_HUMAN	Ras-related protein Rab-7b	RAB7B	Homo sapiens (Human)	199	FUNCTION: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. {ECO:0000269|PubMed:20375062, ECO:0000269|PubMed:20953574}.		cellular response to type II interferon [GO:0071346]; endosome to lysosome transport [GO:0008333]; late endosome to Golgi transport [GO:0034499]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; phagosome-lysosome fusion [GO:0090385]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein transport [GO:0015031]	Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; trans-Golgi network [GO:0005802]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; trans-Golgi network [GO:0005802]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cellular response to type II interferon [GO:0071346]; endosome to lysosome transport [GO:0008333]; late endosome to Golgi transport [GO:0034499]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; phagosome-lysosome fusion [GO:0090385]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:20375062}. Lysosome {ECO:0000269|PubMed:15144907, ECO:0000269|PubMed:20375062}. Golgi apparatus {ECO:0000269|PubMed:20375062}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:20375062}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269|PubMed:21255211}.
Q96AJ1	reviewed	CLUA1_HUMAN	Clusterin-associated protein 1 (Qilin)	CLUAP1 KIAA0643	Homo sapiens (Human)	413	FUNCTION: Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. {ECO:0000250|UniProtKB:Q8R3P7}.	MISCELLANEOUS: Associated with a number of cancers such as colon (PubMed:15480429) and bone cancer (PubMed:17203229). Possibly involved in polycystic kidney diseases (PubMed:15530380). {ECO:0000305|PubMed:15480429, ECO:0000305|PubMed:15530380, ECO:0000305|PubMed:17203229}.	axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; floor plate formation [GO:0021508]; heart looping [GO:0001947]; intraciliary anterograde transport [GO:0035720]; neural tube closure [GO:0001843]; smoothened signaling pathway [GO:0007224]	centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intracellular membrane-bounded organelle [GO:0043231]; intraciliary transport particle A [GO:0030991]; intraciliary transport particle B [GO:0030992]; nucleoplasm [GO:0005654]		centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intracellular membrane-bounded organelle [GO:0043231]; intraciliary transport particle A [GO:0030991]; intraciliary transport particle B [GO:0030992]; nucleoplasm [GO:0005654]; axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; floor plate formation [GO:0021508]; heart looping [GO:0001947]; intraciliary anterograde transport [GO:0035720]; neural tube closure [GO:0001843]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:15530380}. Nucleus {ECO:0000269|PubMed:15480429}.
Q96AJ9	reviewed	VTI1A_HUMAN	Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2)	VTI1A	Homo sapiens (Human)	217	FUNCTION: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}.		autophagy [GO:0006914]; endocytic recycling [GO:0032456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; retrograde transport, endosome to Golgi [GO:0042147]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle fusion with Golgi apparatus [GO:0048280]; voluntary musculoskeletal movement [GO:0050882]	autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; autophagy [GO:0006914]; endocytic recycling [GO:0032456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; retrograde transport, endosome to Golgi [GO:0042147]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle fusion with Golgi apparatus [GO:0048280]; voluntary musculoskeletal movement [GO:0050882]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:19138172}. Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Q96AK3	reviewed	ABC3D_HUMAN	DNA dC->dU-editing enzyme APOBEC-3D (A3D) (A3DE) (EC 3.5.4.38)	APOBEC3D APOBEC3DE	Homo sapiens (Human)	386	FUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms (PubMed:16920826, PubMed:20062055, PubMed:21835787). Exhibits antiviral activity against HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:16920826). The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Inhibits also the mobility of LTR and non-LTR retrotransposons (PubMed:27428332). {ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:16920826, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22807680, ECO:0000269|PubMed:23097438, ECO:0000269|PubMed:23152537}.; FUNCTION: (Microbial infection) Enhances hepatitis B virus/HBV replication by excluding restriction factors APOBEC3F and APOBEC3G from HBV capsids. {ECO:0000269|PubMed:27289067}.	MISCELLANEOUS: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.	clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]	cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27289067, ECO:0000269|PubMed:27428332}. Cytoplasm, P-body.
Q96AN5	reviewed	TM143_HUMAN	Transmembrane protein 143	TMEM143 UNQ5922/PRO19813	Homo sapiens (Human)	459				membrane [GO:0016020]; mitochondrion [GO:0005739]		membrane [GO:0016020]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96AP0	reviewed	ACD_HUMAN	Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein)	ACD PIP1 PTOP TINT1 TPP1	Homo sapiens (Human)	458	FUNCTION: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. {ECO:0000269|PubMed:15181449, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378, ECO:0000269|PubMed:17237768, ECO:0000269|PubMed:20231318, ECO:0000269|PubMed:25205116, ECO:0000269|PubMed:25233904}.		embryonic limb morphogenesis [GO:0030326]; establishment of protein localization to telomere [GO:0070200]; intracellular protein transport [GO:0006886]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of single-stranded telomeric DNA binding [GO:0060381]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; segmentation [GO:0035282]; skeletal system development [GO:0001501]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; urogenital system development [GO:0001655]	chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; shelterin complex [GO:0070187]; telomerase holoenzyme complex [GO:0005697]	DNA polymerase binding [GO:0070182]; protein-containing complex binding [GO:0044877]; telomeric DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; shelterin complex [GO:0070187]; telomerase holoenzyme complex [GO:0005697]; DNA polymerase binding [GO:0070182]; protein-containing complex binding [GO:0044877]; telomeric DNA binding [GO:0042162]; embryonic limb morphogenesis [GO:0030326]; establishment of protein localization to telomere [GO:0070200]; intracellular protein transport [GO:0006886]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of single-stranded telomeric DNA binding [GO:0060381]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; segmentation [GO:0035282]; skeletal system development [GO:0001501]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; urogenital system development [GO:0001655]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15181449, ECO:0000269|PubMed:25205116, ECO:0000269|PubMed:25233904}. Chromosome, telomere {ECO:0000269|PubMed:15181449, ECO:0000269|PubMed:25205116, ECO:0000269|PubMed:25233904}.
Q96AP4	reviewed	ZUP1_HUMAN	Zinc finger-containing ubiquitin peptidase 1 (EC 3.4.19.12) (Lys-63-specific deubiquitinase ZUFSP) (DUB) (Zinc finger with UFM1-specific peptidase domain protein)	ZUP1 C6orf113 ZUFSP	Homo sapiens (Human)	578	FUNCTION: Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains (PubMed:29576528, PubMed:29563501, PubMed:29476094). Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage (PubMed:29576528, PubMed:29576527). Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress (PubMed:29563501). {ECO:0000269|PubMed:29476094, ECO:0000269|PubMed:29563501, ECO:0000269|PubMed:29576527, ECO:0000269|PubMed:29576528}.			cytosol [GO:0005829]; nucleoplasm [GO:0005654]	cysteine-type deubiquitinase activity [GO:0004843]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; cysteine-type deubiquitinase activity [GO:0004843]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29476094}. Nucleus {ECO:0000269|PubMed:29476094, ECO:0000269|PubMed:29576527, ECO:0000269|PubMed:29576528}. Note=Mostly present in the nuclear fraction. Localizes to DNA lesions. {ECO:0000269|PubMed:29576527, ECO:0000269|PubMed:29576528}.
Q96AP7	reviewed	ESAM_HUMAN	Endothelial cell-selective adhesion molecule	ESAM UNQ220/PRO246	Homo sapiens (Human)	390	FUNCTION: Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250}.		bicellular tight junction assembly [GO:0070830]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of blood-brain barrier [GO:0035633]; protein localization [GO:0008104]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	cell-cell adhesion mediator activity [GO:0098632]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; cell-cell adhesion mediator activity [GO:0098632]; bicellular tight junction assembly [GO:0070830]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of blood-brain barrier [GO:0035633]; protein localization [GO:0008104]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q96AQ6	reviewed	PBIP1_HUMAN	Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein)	PBXIP1 HPIP	Homo sapiens (Human)	731	FUNCTION: Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}.		articular cartilage development [GO:0061975]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; extracellular matrix disassembly [GO:0022617]; gene expression involved in extracellular matrix organization [GO:1901148]; hemopoiesis [GO:0030097]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of Wnt signaling pathway [GO:0030177]; production of molecular mediator involved in inflammatory response [GO:0002532]	chromatin [GO:0000785]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor binding [GO:0140297]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor binding [GO:0140297]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; articular cartilage development [GO:0061975]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; extracellular matrix disassembly [GO:0022617]; gene expression involved in extracellular matrix organization [GO:1901148]; hemopoiesis [GO:0030097]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of Wnt signaling pathway [GO:0030177]; production of molecular mediator involved in inflammatory response [GO:0002532]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. Nucleus {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403}. Note=Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).
Q96AQ7	reviewed	CIDEC_HUMAN	Lipid transferase CIDEC (Cell death activator CIDE-3) (Cell death-inducing DFFA-like effector protein C) (Fat-specific protein FSP27 homolog)	CIDEC FSP27	Homo sapiens (Human)	238	FUNCTION: Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566, PubMed:30361435). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566). Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1 (PubMed:23399566). May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (By similarity). When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment (PubMed:12429024). {ECO:0000250|UniProtKB:P56198, ECO:0000269|PubMed:12429024, ECO:0000269|PubMed:18334488, ECO:0000269|PubMed:19843876, ECO:0000269|PubMed:20049731, ECO:0000269|PubMed:23399566, ECO:0000269|PubMed:30361435}.		apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; lipid droplet fusion [GO:0160077]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of triglyceride metabolic process [GO:0090209]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; nucleus [GO:0005634]	lipid transfer activity [GO:0120013]; molecular condensate scaffold activity [GO:0140693]; phosphatidic acid binding [GO:0070300]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; lipid transfer activity [GO:0120013]; molecular condensate scaffold activity [GO:0140693]; phosphatidic acid binding [GO:0070300]; apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; lipid droplet fusion [GO:0160077]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of triglyceride metabolic process [GO:0090209]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:18334488, ECO:0000269|PubMed:23399566}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P56198}. Nucleus {ECO:0000250|UniProtKB:P56198}. Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites. {ECO:0000250|UniProtKB:P56198}.
Q96AQ8	reviewed	MCUR1_HUMAN	Mitochondrial calcium uniporter regulator 1 (MCU regulator 1) (Coiled-coil domain-containing protein 90A, mitochondrial)	MCUR1 C6orf79 CCDC90A	Homo sapiens (Human)	359	FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883). Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846). {ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:26445506, ECO:0000269|PubMed:26976564, ECO:0000269|PubMed:27184846}.		calcium import into the mitochondrion [GO:0036444]; calcium ion import [GO:0070509]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; calcium import into the mitochondrion [GO:0036444]; calcium ion import [GO:0070509]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:23178883}; Multi-pass membrane protein {ECO:0000269|PubMed:23178883}.
Q96AT9	reviewed	RPE_HUMAN	Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Ribulose-5-phosphate-3-epimerase)	RPE HUSSY-17	Homo sapiens (Human)	228	FUNCTION: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. {ECO:0000269|PubMed:20923965}.		carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	D-ribulose-phosphate 3-epimerase activity [GO:0004750]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; D-ribulose-phosphate 3-epimerase activity [GO:0004750]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]	
Q96AV8	reviewed	E2F7_HUMAN	Transcription factor E2F7 (E2F-7)	E2F7	Homo sapiens (Human)	911	FUNCTION: Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269|PubMed:14633988, ECO:0000269|PubMed:15133492, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:19223542, ECO:0000269|PubMed:21248772, ECO:0000269|PubMed:22802528, ECO:0000269|PubMed:22802529, ECO:0000269|PubMed:22903062}.		chorionic trophoblast cell differentiation [GO:0060718]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; hepatocyte differentiation [GO:0070365]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytokinesis [GO:0032466]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071930]; placenta development [GO:0001890]; positive regulation of DNA endoreduplication [GO:0032877]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sprouting angiogenesis [GO:0002040]; trophoblast giant cell differentiation [GO:0060707]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; chorionic trophoblast cell differentiation [GO:0060718]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; hepatocyte differentiation [GO:0070365]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytokinesis [GO:0032466]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071930]; placenta development [GO:0001890]; positive regulation of DNA endoreduplication [GO:0032877]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sprouting angiogenesis [GO:0002040]; trophoblast giant cell differentiation [GO:0060707]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15133492}.
Q96AW1	reviewed	VOPP1_HUMAN	WW domain binding protein VOPP1 (EGFR-coamplified and overexpressed protein) (ECop) (Glioblastoma-amplified secreted protein) (Putative NF-kappa-B-activating protein 055N) (Vesicular, overexpressed in cancer, prosurvival protein 1)	VOPP1 ECOP GASP	Homo sapiens (Human)	172	FUNCTION: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed (PubMed:15735698). May sequester WWOX in lysosomal vesicles and thereby regulate WWOX role as tumor suppressor (PubMed:30285739). {ECO:0000269|PubMed:15735698, ECO:0000269|PubMed:30285739}.			cytoplasmic vesicle membrane [GO:0030659]; endosome [GO:0005768]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; organelle membrane [GO:0031090]	enzyme binding [GO:0019899]	cytoplasmic vesicle membrane [GO:0030659]; endosome [GO:0005768]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; organelle membrane [GO:0031090]; enzyme binding [GO:0019899]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:20571887}; Single-pass type I membrane protein {ECO:0000269|PubMed:20571887}. Late endosome membrane {ECO:0000269|PubMed:30285739}; Single-pass membrane protein {ECO:0000269|PubMed:30285739}. Lysosome membrane {ECO:0000269|PubMed:30285739}; Single-pass membrane protein {ECO:0000269|PubMed:30285739}. Note=When overexpressed, localizes in the nucleus and perinuclear regions. {ECO:0000269|PubMed:15735698}.
Q96AX1	reviewed	VP33A_HUMAN	Vacuolar protein sorting-associated protein 33A (hVPS33A)	VPS33A	Homo sapiens (Human)	596	FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770). {ECO:0000269|PubMed:24554770, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25266290, ECO:0000305|PubMed:25783203}.		autophagosome maturation [GO:0097352]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; melanosome localization [GO:0032400]; platelet formation [GO:0030220]; regulation of developmental pigmentation [GO:0048070]; regulation of lysosomal lumen pH [GO:0035751]; regulation of SNARE complex assembly [GO:0035542]; vesicle-mediated transport [GO:0016192]	autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]		autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; autophagosome maturation [GO:0097352]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; melanosome localization [GO:0032400]; platelet formation [GO:0030220]; regulation of developmental pigmentation [GO:0048070]; regulation of lysosomal lumen pH [GO:0035751]; regulation of SNARE complex assembly [GO:0035542]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q63615}. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000305}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24554770}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000305}.
Q96AX2	reviewed	RAB37_HUMAN	Ras-related protein Rab-37	RAB37	Homo sapiens (Human)	223			protein transport [GO:0015031]	azurophil granule membrane [GO:0035577]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	azurophil granule membrane [GO:0035577]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasmic vesicle. Note=Secretory granules. {ECO:0000250}.
Q96AX9	reviewed	MIB2_HUMAN	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1)	MIB2 SKD ZZANK1	Homo sapiens (Human)	955	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. {ECO:0000250|UniProtKB:Q8R516}.		Notch signaling pathway [GO:0007219]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein ubiquitination [GO:0016567]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]	cytosol [GO:0005829]; early endosome [GO:0005769]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	actin binding [GO:0003779]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; early endosome [GO:0005769]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; actin binding [GO:0003779]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; Notch signaling pathway [GO:0007219]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein ubiquitination [GO:0016567]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14507647}. Endosome {ECO:0000269|PubMed:14507647}. Note=Colocalizes with endosomal compartments.
Q96AY2	reviewed	EME1_HUMAN	Crossover junction endonuclease EME1 (EC 3.1.22.-) (MMS4 homolog) (hMMS4)	EME1 MMS4	Homo sapiens (Human)	570	FUNCTION: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:17289582}.		double-strand break repair [GO:0006302]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]; response to intra-S DNA damage checkpoint signaling [GO:0072429]	endodeoxyribonuclease complex [GO:1905347]; heterochromatin [GO:0000792]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]	endodeoxyribonuclease complex [GO:1905347]; heterochromatin [GO:0000792]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; double-strand break repair [GO:0006302]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]; response to intra-S DNA damage checkpoint signaling [GO:0072429]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:14617801}. Note=Recruited to regions of DNA damage in S-phase cells.
Q96AY3	reviewed	FKB10_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP10 (PPIase FKBP10) (EC 5.2.1.8) (65 kDa FK506-binding protein) (65 kDa FKBP) (FKBP-65) (FK506-binding protein 10) (FKBP-10) (Immunophilin FKBP65) (Rotamase)	FKBP10 FKBP65 PSEC0056	Homo sapiens (Human)	582	FUNCTION: PPIases accelerate the folding of proteins during protein synthesis.		aorta morphogenesis [GO:0035909]; collagen fibril organization [GO:0030199]; extracellular matrix assembly [GO:0085029]; in utero embryonic development [GO:0001701]; peptidyl-proline modification [GO:0018208]; protein folding [GO:0006457]; wound healing [GO:0042060]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]	calcium ion binding [GO:0005509]; FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; calcium ion binding [GO:0005509]; FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; aorta morphogenesis [GO:0035909]; collagen fibril organization [GO:0030199]; extracellular matrix assembly [GO:0085029]; in utero embryonic development [GO:0001701]; peptidyl-proline modification [GO:0018208]; protein folding [GO:0006457]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q96AY4	reviewed	TTC28_HUMAN	Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio)	TTC28 KIAA1043 TPRBK	Homo sapiens (Human)	2481	FUNCTION: During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}.		cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of mitotic cell cycle [GO:0007346]	cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; spindle pole [GO:0000922]	kinase binding [GO:0019900]	cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; spindle pole [GO:0000922]; kinase binding [GO:0019900]; cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Midbody {ECO:0000250}. Note=At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity). {ECO:0000250}.
Q96AZ1	reviewed	EFMT3_HUMAN	EEF1A lysine methyltransferase 3 (EC 2.1.1.-) (Hepatocellular carcinoma-associated antigen 557a) (Methyltransferase-like protein 21B) (Protein-lysine methyltransferase METTL21B) (eEF1A-KMT3)	EEF1AKMT3 FAM119B HCA557A METTL21B	Homo sapiens (Human)	226	FUNCTION: Protein-lysine methyltransferase that selectively mono-, di- and trimethylates 'Lys-165' of the translation elongation factors EEF1A1 and EEF1A2 in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. {ECO:0000269|PubMed:28108655, ECO:0000269|PubMed:28663172}.		peptidyl-lysine methylation [GO:0018022]	centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	heat shock protein binding [GO:0031072]; histone methyltransferase activity [GO:0042054]; methyltransferase activity [GO:0008168]; protein-lysine N-methyltransferase activity [GO:0016279]	centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; heat shock protein binding [GO:0031072]; histone methyltransferase activity [GO:0042054]; methyltransferase activity [GO:0008168]; protein-lysine N-methyltransferase activity [GO:0016279]; peptidyl-lysine methylation [GO:0018022]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23349634, ECO:0000269|PubMed:28108655}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28108655}.
Q96AZ6	reviewed	ISG20_HUMAN	Interferon-stimulated gene 20 kDa protein (EC 3.1.13.1) (Estrogen-regulated transcript 45 protein) (Promyelocytic leukemia nuclear body-associated protein ISG20)	ISG20 HEM45	Homo sapiens (Human)	181	FUNCTION: Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA (PubMed:11401564, PubMed:12594219, PubMed:16033969). Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) (PubMed:16514659, PubMed:21036379). Inhibition of several viruses such as chikungunya virus (CHIKV) does not involve the degradation of viral RNAs, but rather the inhibition of translation of viral proteins (By similarity). Exerts a translational control over a large panel of non-self RNA substrates while sparing endogenous transcripts. This activity correlates with the protein's ability to localize in cytoplasmic processing bodies (PubMed:31600344). May also act as master regulator of over hundred interferon stimulated genes leading to viral genome translation inhibition (By similarity). May play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (PubMed:16514659). {ECO:0000250|UniProtKB:Q9JL16, ECO:0000269|PubMed:11401564, ECO:0000269|PubMed:12594219, ECO:0000269|PubMed:16033969, ECO:0000269|PubMed:16514659, ECO:0000269|PubMed:21036379, ECO:0000269|PubMed:31600344}.		defense response to virus [GO:0051607]; DNA catabolic process [GO:0006308]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; response to virus [GO:0009615]; RNA catabolic process [GO:0006401]; rRNA processing [GO:0006364]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; PML body [GO:0016605]	3'-5'-RNA exonuclease activity [GO:0000175]; exonuclease activity [GO:0004527]; exoribonuclease II activity [GO:0008859]; metal ion binding [GO:0046872]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U3 snoRNA binding [GO:0034511]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; PML body [GO:0016605]; 3'-5'-RNA exonuclease activity [GO:0000175]; exonuclease activity [GO:0004527]; exoribonuclease II activity [GO:0008859]; metal ion binding [GO:0046872]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U3 snoRNA binding [GO:0034511]; defense response to virus [GO:0051607]; DNA catabolic process [GO:0006308]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; response to virus [GO:0009615]; RNA catabolic process [GO:0006401]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16514659}. Nucleus, nucleolus {ECO:0000269|PubMed:16514659}. Cytoplasm {ECO:0000269|PubMed:31600344}. Nucleus, Cajal body {ECO:0000269|PubMed:16514659}. Cytoplasm, P-body {ECO:0000269|PubMed:31600344}.
Q96B01	reviewed	R51A1_HUMAN	RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein)	RAD51AP1 PIR51	Homo sapiens (Human)	352	FUNCTION: Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:9396801, PubMed:17996711, PubMed:22375013, PubMed:17996710). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27463890, PubMed:27239033, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801). {ECO:0000269|PubMed:17996710, ECO:0000269|PubMed:17996711, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:22375013, ECO:0000269|PubMed:25288561, ECO:0000269|PubMed:26323318, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31400850, ECO:0000269|PubMed:32350107, ECO:0000269|PubMed:9396801}.		cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; meiotic cell cycle [GO:0051321]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of double-strand break repair via homologous recombination [GO:0010569]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	D-loop DNA binding [GO:0062037]; DNA binding [GO:0003677]; DNA secondary structure binding [GO:0000217]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; D-loop DNA binding [GO:0062037]; DNA binding [GO:0003677]; DNA secondary structure binding [GO:0000217]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; meiotic cell cycle [GO:0051321]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of double-strand break repair via homologous recombination [GO:0010569]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:26323318, ECO:0000269|PubMed:31400850}. Nucleus {ECO:0000269|PubMed:26323318}. Chromosome, telomere {ECO:0000269|PubMed:31400850}. Note=Colocalizes with RAD51 to multiple nuclear foci (By similarity). Colocalizes with DMC1 on meiotic chromatin (By similarity). {ECO:0000250|UniProtKB:Q8C551}.
Q96B02	reviewed	UBE2W_HUMAN	Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)	UBE2W UBC16	Homo sapiens (Human)	151	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386, PubMed:21229326). Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini (PubMed:23560854, PubMed:23696636, PubMed:25436519). Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:19111657, PubMed:21229326). In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate (PubMed:25436519). {ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:21229326, ECO:0000269|PubMed:23560854, ECO:0000269|PubMed:23696636, ECO:0000269|PubMed:25436519}.		antiviral innate immune response [GO:0140374]; cellular response to misfolded protein [GO:0071218]; DNA repair [GO:0006281]; negative regulation of TORC1 signaling [GO:1904262]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein monoubiquitination [GO:0006513]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; antiviral innate immune response [GO:0140374]; cellular response to misfolded protein [GO:0071218]; DNA repair [GO:0006281]; negative regulation of TORC1 signaling [GO:1904262]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein monoubiquitination [GO:0006513]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16368532, ECO:0000269|PubMed:21229326}. Note=In the nucleus, colocalizes with FANCL. {ECO:0000269|PubMed:21229326}.
Q96B18	reviewed	DACT3_HUMAN	Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3)	DACT3 RRR1	Homo sapiens (Human)	629	FUNCTION: May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}.		canonical Wnt signaling pathway [GO:0060070]; epithelial to mesenchymal transition [GO:0001837]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of Wnt signaling pathway [GO:0030178]	cytoplasm [GO:0005737]	delta-catenin binding [GO:0070097]; identical protein binding [GO:0042802]; protein kinase A binding [GO:0051018]; protein kinase C binding [GO:0005080]	cytoplasm [GO:0005737]; delta-catenin binding [GO:0070097]; identical protein binding [GO:0042802]; protein kinase A binding [GO:0051018]; protein kinase C binding [GO:0005080]; canonical Wnt signaling pathway [GO:0060070]; epithelial to mesenchymal transition [GO:0001837]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of Wnt signaling pathway [GO:0030178]	
Q96B21	reviewed	TM45B_HUMAN	Transmembrane protein 45B	TMEM45B	Homo sapiens (Human)	275	FUNCTION: Plays a role in innate immunity (PubMed:35938871). Mechanistically, promotes alphaviruses RNA degradation by interacting with the viral polymerase nsP4 and the mRNA-capping enzyme nsP1 and thereby interfering with the interaction between viral RNA and nsP1.(PubMed:35938871). {ECO:0000269|PubMed:35938871}.		innate immune response [GO:0045087]	endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]		endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:35938871}; Multi-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:35938871}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:35938871}; Multi-pass membrane protein {ECO:0000305}.
Q96B23	reviewed	ARK2N_HUMAN	Protein ARK2N (ARKadia (RNF111) N-terminal like PKA signaling regulator protein 2N) (ARKadia-like protein 1)	ARK2N ARKL1 C18orf25	Homo sapiens (Human)	404	FUNCTION: AMPK substrate important for exercise capacity and skeletal muscle function. Required for normal contraction-induced signaling. {ECO:0000269|PubMed:35882232}.; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, suppresses viral BZLF1 expression and subsequent EBV reactivation by interacting with JUN and inhibiting its transcriptional activitor activity on BZLF1 Z promoter. {ECO:0000269|PubMed:31341047}.		negative regulation of viral life cycle [GO:1903901]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromatin [GO:0000785]; nucleus [GO:0005634]	transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of viral life cycle [GO:1903901]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31341047}.
Q96B26	reviewed	EXOS8_HUMAN	Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9)	EXOSC8 OIP2 RRP43	Homo sapiens (Human)	276	FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs. {ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}.		exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; mRNA 3'-UTR AU-rich region binding [GO:0035925]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000250}.
Q96B36	reviewed	AKTS1_HUMAN	Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate)	AKT1S1 PRAS40	Homo sapiens (Human)	256	FUNCTION: Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17510057, PubMed:17386266, PubMed:17277771, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity). {ECO:0000250|UniProtKB:Q9D1F4, ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266, ECO:0000269|PubMed:17510057, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:29236692}.		negative regulation of cell size [GO:0045792]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of apoptotic process [GO:0042981]; regulation of neuron apoptotic process [GO:0043523]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; TORC1 complex [GO:0031931]	protein kinase inhibitor activity [GO:0004860]; protein serine/threonine kinase inhibitor activity [GO:0030291]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; TORC1 complex [GO:0031931]; protein kinase inhibitor activity [GO:0004860]; protein serine/threonine kinase inhibitor activity [GO:0030291]; negative regulation of cell size [GO:0045792]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of apoptotic process [GO:0042981]; regulation of neuron apoptotic process [GO:0043523]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D1F4}. Note=Found in the cytosolic fraction of the brain. {ECO:0000250|UniProtKB:Q9D1F4}.
Q96B42	reviewed	TMM18_HUMAN	Transmembrane protein 18	TMEM18	Homo sapiens (Human)	140	FUNCTION: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC). {ECO:0000269|PubMed:18559506, ECO:0000269|PubMed:21980424}.		cell migration [GO:0016477]; eating behavior [GO:0042755]; energy homeostasis [GO:0097009]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]	DNA binding [GO:0003677]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; DNA binding [GO:0003677]; cell migration [GO:0016477]; eating behavior [GO:0042755]; energy homeostasis [GO:0097009]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18559506, ECO:0000269|PubMed:21980424}. Nucleus membrane {ECO:0000269|PubMed:18559506, ECO:0000269|PubMed:21980424}; Multi-pass membrane protein {ECO:0000255}.
Q96B49	reviewed	TOM6_HUMAN	Mitochondrial import receptor subunit TOM6 homolog (Overexpressed breast tumor protein) (Translocase of outer membrane 6 kDa subunit homolog)	TOMM6 OBTP TOM6	Homo sapiens (Human)	74			protein insertion into mitochondrial outer membrane [GO:0045040]	mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]		mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; protein insertion into mitochondrial outer membrane [GO:0045040]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18331822}.
Q96B67	reviewed	ARRD3_HUMAN	Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)	ARRDC3 KIAA1376	Homo sapiens (Human)	414	FUNCTION: Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550). {ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}.		fat pad development [GO:0060613]; heat generation [GO:0031649]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of heat generation [GO:0031651]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; positive regulation of hippo signaling [GO:0035332]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein transport [GO:0015031]; skin development [GO:0043588]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	beta-3 adrenergic receptor binding [GO:0031699]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; beta-3 adrenergic receptor binding [GO:0031699]; fat pad development [GO:0060613]; heat generation [GO:0031649]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of heat generation [GO:0031651]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; positive regulation of hippo signaling [GO:0035332]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein transport [GO:0015031]; skin development [GO:0043588]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:23208550}. Cell membrane {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}; Peripheral membrane protein {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:20559325}; Cytoplasmic side {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:20559325}. Lysosome {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:23208550}. Endosome {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:23208550}. Early endosome {ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}. Note=Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis (PubMed:16269462, PubMed:23208550, PubMed:20559325). {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}.
Q96B86	reviewed	RGMA_HUMAN	Repulsive guidance molecule A (RGM domain family member A)	RGMA RGM	Homo sapiens (Human)	450	FUNCTION: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. {ECO:0000269|PubMed:19273616, ECO:0000269|PubMed:19458235}.		BMP signaling pathway [GO:0030509]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of axon regeneration [GO:0048681]; negative regulation of collateral sprouting [GO:0048671]; neural tube closure [GO:0001843]; neuron projection development [GO:0031175]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of BMP signaling pathway [GO:0030510]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	coreceptor activity [GO:0015026]; transferrin receptor binding [GO:1990459]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; coreceptor activity [GO:0015026]; transferrin receptor binding [GO:1990459]; BMP signaling pathway [GO:0030509]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of axon regeneration [GO:0048681]; negative regulation of collateral sprouting [GO:0048671]; neural tube closure [GO:0001843]; neuron projection development [GO:0031175]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of BMP signaling pathway [GO:0030510]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Q96B96	reviewed	LDAF1_HUMAN	Lipid droplet assembly factor 1 (Promethin) (Transmembrane protein 159)	LDAF1 TMEM159	Homo sapiens (Human)	161	FUNCTION: Plays an important role in the formation of lipid droplets (LD) which are storage organelles at the center of lipid and energy homeostasis (PubMed:31708432). In association with BSCL2/seipin, defines the sites of LD formation in the endoplasmic reticulum (PubMed:31708432). {ECO:0000269|PubMed:31708432}.		lipid droplet formation [GO:0140042]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]		endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; lipid droplet formation [GO:0140042]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30901948, ECO:0000269|PubMed:31708432}; Multi-pass membrane protein {ECO:0000255}. Lipid droplet {ECO:0000269|PubMed:30901948, ECO:0000269|PubMed:31708432}. Note=Co-localizes with BSCL2/seipin in the ER, upon LD formation dissociates from BSCL2/seipin and relocalizes to LD surfaces during LD maturation. {ECO:0000269|PubMed:31708432}.
Q96B97	reviewed	SH3K1_HUMAN	SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)	SH3KBP1 CIN85	Homo sapiens (Human)	665	FUNCTION: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}.	MISCELLANEOUS: [Isoform 1]: Interacts with CBL.; MISCELLANEOUS: [Isoform 2]: Interacts with CD2 cytoplasmic tail and does not interact with F-actin. {ECO:0000305}.	actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell-cell signaling [GO:0007267]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; positive regulation of B cell activation [GO:0050871]; regulation of cell shape [GO:0008360]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; focal adhesion [GO:0005925]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]	SH3 domain binding [GO:0017124]; ubiquitin protein ligase binding [GO:0031625]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; focal adhesion [GO:0005925]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase binding [GO:0031625]; actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell-cell signaling [GO:0007267]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; positive regulation of B cell activation [GO:0050871]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20221403}. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse, synaptosome. Cell junction, focal adhesion {ECO:0000250}. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes. Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (By similarity). Colocalizes with ZFP36 in the cytoplasm (PubMed:20221403). {ECO:0000250|UniProtKB:Q8R550, ECO:0000269|PubMed:20221403}.
Q96BA8	reviewed	CR3L1_HUMAN	Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) (Old astrocyte specifically-induced substance) (OASIS) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 1]	CREB3L1 OASIS PSEC0238	Homo sapiens (Human)	519	FUNCTION: [Cyclic AMP-responsive element-binding protein 3-like protein 1]: Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane (PubMed:12054625, PubMed:16417584, PubMed:25310401). In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition (PubMed:12054625, PubMed:21767813, PubMed:25310401). {ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:16417584, ECO:0000269|PubMed:21767813, ECO:0000269|PubMed:25310401}.; FUNCTION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 1]: Transcription factor involved in cell type specific DNA damage and unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). In astrocytes and osteoblasts, upon DNA damage, inhibits cell-cycle progression after G2/M phase by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401). {ECO:0000250|UniProtKB:Q9Z125, ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:21767813, ECO:0000269|PubMed:25310401}.; FUNCTION: (Microbial infection) May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813). {ECO:0000269|PubMed:21767813}.		endoplasmic reticulum unfolded protein response [GO:0030968]; extracellular matrix constituent secretion [GO:0070278]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression [GO:0010629]; negative regulation of sprouting angiogenesis [GO:1903671]; osteoblast differentiation [GO:0001649]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cAMP response element binding [GO:0035497]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cAMP response element binding [GO:0035497]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]; endoplasmic reticulum unfolded protein response [GO:0030968]; extracellular matrix constituent secretion [GO:0070278]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression [GO:0010629]; negative regulation of sprouting angiogenesis [GO:1903671]; osteoblast differentiation [GO:0001649]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Cyclic AMP-responsive element-binding protein 3-like protein 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:16417584, ECO:0000269|PubMed:25310401}; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. {ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:16417584, ECO:0000269|PubMed:21767813, ECO:0000269|PubMed:25310401}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 1]: Nucleus {ECO:0000269|PubMed:24079343, ECO:0000269|PubMed:25310401}. Note=Upon ER stress or DNA damage, transported into the nucleus. {ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:21767813, ECO:0000269|PubMed:24079343, ECO:0000269|PubMed:25310401}.
Q96BD0	reviewed	SO4A1_HUMAN	Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12)	SLCO4A1 OATP1 OATP4A1 OATPE SLC21A12	Homo sapiens (Human)	722	FUNCTION: Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:19129463, PubMed:30343886). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (PubMed:30343886). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30343886, ECO:0000305}.		monoatomic ion transport [GO:0006811]; sodium-independent organic anion transport [GO:0043252]	plasma membrane [GO:0005886]	organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349]	plasma membrane [GO:0005886]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349]; monoatomic ion transport [GO:0006811]; sodium-independent organic anion transport [GO:0043252]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:30343886}; Multi-pass membrane protein {ECO:0000255}.
Q96BD5	reviewed	PF21A_HUMAN	PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)	PHF21A BHC80 KIAA1696 BM-006	Homo sapiens (Human)	680	FUNCTION: Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. {ECO:0000269|PubMed:16140033}.		chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]	DNA repair complex [GO:1990391]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]	DNA repair complex [GO:1990391]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96BD6	reviewed	SPSB1_HUMAN	SPRY domain-containing SOCS box protein 1 (SSB-1)	SPSB1 SSB1	Homo sapiens (Human)	273	FUNCTION: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:21199876}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:21199876}. Note=Exhibits a diffuse cytosolic localization. {ECO:0000269|PubMed:21199876}.
Q96BD8	reviewed	SKA1_HUMAN	Spindle and kinetochore-associated protein 1	SKA1 C18orf24	Homo sapiens (Human)	255	FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020). {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:23085020}.		cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; regulation of microtubule polymerization or depolymerization [GO:0031110]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; outer kinetochore [GO:0000940]; spindle microtubule [GO:0005876]	microtubule binding [GO:0008017]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; outer kinetochore [GO:0000940]; spindle microtubule [GO:0005876]; microtubule binding [GO:0008017]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; regulation of microtubule polymerization or depolymerization [GO:0031110]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15561729}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17093495}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner (PubMed:17093495). Localizes to both the mitotic spindle and kinetochore-associated proteins (PubMed:17093495). Associates with kinetochores following microtubule attachment from prometaphase, through mid-anaphase and then vanishes in telophase (PubMed:17093495). {ECO:0000269|PubMed:17093495}.
Q96BF3	reviewed	TMIG2_HUMAN	Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1)	TMIGD2 CD28H IGPR1 UNQ3059/PRO9879	Homo sapiens (Human)	282	FUNCTION: Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}.		B cell receptor signaling pathway [GO:0050853]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytokine production [GO:0001819]; T cell costimulation [GO:0031295]	B cell receptor complex [GO:0019815]	coreceptor activity [GO:0015026]	B cell receptor complex [GO:0019815]; coreceptor activity [GO:0015026]; B cell receptor signaling pathway [GO:0050853]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytokine production [GO:0001819]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22419821}; Single-pass type I membrane protein {ECO:0000269|PubMed:22419821}.
Q96BF6	reviewed	NACC2_HUMAN	Nucleus accumbens-associated protein 2 (NAC-2) (BTB/POZ domain-containing protein 14A) (Repressor with BTB domain and BEN domain)	NACC2 BTBD14A NAC2 RBB	Homo sapiens (Human)	587	FUNCTION: Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. {ECO:0000269|PubMed:22926524}.		negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter [GO:1900477]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; protein homooligomerization [GO:0051260]; protein-containing complex localization [GO:0031503]	chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter [GO:1900477]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; protein homooligomerization [GO:0051260]; protein-containing complex localization [GO:0031503]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22926524}. Note=Predominantly associated with chromatin.
Q96BH1	reviewed	RNF25_HUMAN	E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7)	RNF25	Homo sapiens (Human)	459	FUNCTION: E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793). Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 (PubMed:36638793). RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Also involved in ubiquitination and degradation of stalled ETF1/eRF1 (PubMed:36638793). Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 (PubMed:12748188). {ECO:0000250|UniProtKB:Q9QZR0, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:36638793}.		positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7SXJ6}.
Q96BI1	reviewed	S22AI_HUMAN	Solute carrier family 22 member 18 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A)	SLC22A18 BWR1A BWSCR1A HET IMPT1 ITM ORCTL2 SLC22A1L TSSC5	Homo sapiens (Human)	424	FUNCTION: May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. {ECO:0000269|PubMed:9744804}.		monoatomic ion transport [GO:0006811]; organic cation transport [GO:0015695]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transport [GO:0042908]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]	symporter activity [GO:0015293]; ubiquitin protein ligase binding [GO:0031625]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; symporter activity [GO:0015293]; ubiquitin protein ligase binding [GO:0031625]; xenobiotic transmembrane transporter activity [GO:0042910]; monoatomic ion transport [GO:0006811]; organic cation transport [GO:0015695]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localized at the apical membrane surface of renal proximal tubules. {ECO:0000269|PubMed:9744804}.
Q96BI3	reviewed	APH1A_HUMAN	Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor)	APH1A PSF CGI-78 UNQ579/PRO1141	Homo sapiens (Human)	265	FUNCTION: Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12763021, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Required for normal gamma-secretase assembly (PubMed:12522139, PubMed:12471034, PubMed:12763021, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). {ECO:0000269|PubMed:12297508, ECO:0000269|PubMed:12471034, ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12763021, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000305}.		amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; metanephros development [GO:0001656]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485]	early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]	endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]; protein-macromolecule adaptor activity [GO:0030674]	early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]; protein-macromolecule adaptor activity [GO:0030674]; amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; metanephros development [GO:0001656]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12522139}; Multi-pass membrane protein {ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12522139}; Multi-pass membrane protein {ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. {ECO:0000269|PubMed:12522139}.
Q96BJ3	reviewed	AIDA_HUMAN	Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist)	AIDA C1orf80	Homo sapiens (Human)	306	FUNCTION: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). {ECO:0000250}.		determination of ventral identity [GO:0048264]; dorsal/ventral pattern formation [GO:0009953]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of protein-containing complex assembly [GO:0031333]	cytoplasm [GO:0005737]; membrane [GO:0016020]	phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]; membrane [GO:0016020]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; determination of ventral identity [GO:0048264]; dorsal/ventral pattern formation [GO:0009953]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of protein-containing complex assembly [GO:0031333]	
Q96BK5	reviewed	PINX1_HUMAN	PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1)	PINX1 LPTL LPTS	Homo sapiens (Human)	328	FUNCTION: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269|PubMed:15381700, ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989, ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617, ECO:0000269|PubMed:19553660}.		mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of telomeric DNA binding [GO:1904744]; protein localization to chromosome, telomeric region [GO:0070198]; protein localization to nucleolus [GO:1902570]; regulation of protein stability [GO:0031647]; regulation of telomerase activity [GO:0051972]; telomere maintenance via telomerase [GO:0007004]	chromosome, telomeric region [GO:0000781]; kinetochore [GO:0000776]; mitochondrion [GO:0005739]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle [GO:0005819]	protein-containing complex binding [GO:0044877]; telomerase inhibitor activity [GO:0010521]; telomerase RNA binding [GO:0070034]	chromosome, telomeric region [GO:0000781]; kinetochore [GO:0000776]; mitochondrion [GO:0005739]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; protein-containing complex binding [GO:0044877]; telomerase inhibitor activity [GO:0010521]; telomerase RNA binding [GO:0070034]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of telomeric DNA binding [GO:1904744]; protein localization to chromosome, telomeric region [GO:0070198]; protein localization to nucleolus [GO:1902570]; regulation of protein stability [GO:0031647]; regulation of telomerase activity [GO:0051972]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27847364}. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
Q96BM1	reviewed	ANKR9_HUMAN	Ankyrin repeat domain-containing protein 9	ANKRD9	Homo sapiens (Human)	317	FUNCTION: Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:30293565). Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly (PubMed:30293565, PubMed:31337707). Implicated in different cellular processes, like copper homeostasis and cell proliferation (PubMed:24522796, PubMed:30293565). {ECO:0000269|PubMed:24522796, ECO:0000269|PubMed:30293565, ECO:0000269|PubMed:31337707}.		intracellular copper ion homeostasis [GO:0006878]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; intracellular copper ion homeostasis [GO:0006878]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:31337707}. Cytoplasm, cytosol {ECO:0000269|PubMed:30293565, ECO:0000269|PubMed:31337707}. Note=Detected in long filamentous cytosolic structures where it colocalizes with IMPDH2 (PubMed:31337707). Under basal conditions ANKRD9 is mainly in vesicle-like structures, upon nutrient limitation (guanine nucleotides deficiency) ANKRD9 loses its vesicular pattern and assembles with IMPDH2 into rodlike filaments (PubMed:31337707). {ECO:0000269|PubMed:31337707}.
Q96BM9	reviewed	ARL8A_HUMAN	ADP-ribosylation factor-like protein 8A (ADP-ribosylation factor-like protein 10B) (Novel small G protein indispensable for equal chromosome segregation 2)	ARL8A ARL10B GIE2	Homo sapiens (Human)	186	FUNCTION: Plays a role in lysosome motility (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity). {ECO:0000250|UniProtKB:Q9CQW2, ECO:0000250|UniProtKB:Q9NVJ2}.		anterograde axonal transport [GO:0008089]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; protein transport [GO:0015031]	axon cytoplasm [GO:1904115]; azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; midbody [GO:0030496]; plasma membrane [GO:0005886]; spindle midzone [GO:0051233]; synapse [GO:0045202]	alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	axon cytoplasm [GO:1904115]; azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; midbody [GO:0030496]; plasma membrane [GO:0005886]; spindle midzone [GO:0051233]; synapse [GO:0045202]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; anterograde axonal transport [GO:0008089]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q9NVJ2}. Lysosome membrane {ECO:0000250|UniProtKB:Q9CQW2}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9NVJ2}. Cell projection, axon {ECO:0000250|UniProtKB:Q9CQW2}. Synapse {ECO:0000250|UniProtKB:Q9CQW2}. Note=Localizes with microtubules at the spindle mid-zone during mitosis. {ECO:0000250|UniProtKB:Q9NVJ2}.
Q96BN2	reviewed	TADA1_HUMAN	Transcriptional adapter 1 (SPT3-associated factor 42) (STAF42) (Transcriptional adapter 1-like protein)	TADA1 TADA1L	Homo sapiens (Human)	335	FUNCTION: Probably involved in transcriptional regulation.		positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]	transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription coactivator activity [GO:0003713]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863}.
Q96BN8	reviewed	OTUL_HUMAN	Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby)	OTULIN FAM105B	Homo sapiens (Human)	352	FUNCTION: Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:26997266, PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327, PubMed:28919039, PubMed:35170849, PubMed:35587511). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (PubMed:23806334). {ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0000269|PubMed:23806334, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:24726323, ECO:0000269|PubMed:24726327, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27523608, ECO:0000269|PubMed:27559085, ECO:0000269|PubMed:28919039, ECO:0000269|PubMed:35170849, ECO:0000269|PubMed:35587511}.		innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; protein linear deubiquitination [GO:1990108]; protein ubiquitination [GO:0016567]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; sprouting angiogenesis [GO:0002040]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; LUBAC complex [GO:0071797]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; LUBAC complex [GO:0071797]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; protein linear deubiquitination [GO:1990108]; protein ubiquitination [GO:0016567]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; sprouting angiogenesis [GO:0002040]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23746843}.
Q96BP2	reviewed	CHCH1_HUMAN	Small ribosomal subunit protein mS37 (28S ribosomal protein S37, mitochondrial) (MRP-S37) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 1) (Nuclear protein C2360)	CHCHD1 C10orf34 MRPS37	Homo sapiens (Human)	118			mitochondrial translation [GO:0032543]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23908630}. Nucleus {ECO:0000269|PubMed:15177562}.
Q96BP3	reviewed	PPWD1_HUMAN	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) (Spliceosome-associated cyclophilin)	PPWD1 KIAA0073	Homo sapiens (Human)	646	FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:20676357}.		mRNA splicing, via spliceosome [GO:0000398]; protein peptidyl-prolyl isomerization [GO:0000413]	catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; mRNA splicing, via spliceosome [GO:0000398]; protein peptidyl-prolyl isomerization [GO:0000413]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18397323}. Note=Associated with spliceosomal complexes. {ECO:0000269|PubMed:11991638}.
Q96BR1	reviewed	SGK3_HUMAN	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like)	SGK3 CISK SGKL	Homo sapiens (Human)	496	FUNCTION: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. {ECO:0000269|PubMed:12054501, ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12632189, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:12650886, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:14706641, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15044175, ECO:0000269|PubMed:15319523, ECO:0000269|PubMed:15496163, ECO:0000269|PubMed:15737648, ECO:0000269|PubMed:15845389, ECO:0000269|PubMed:16036218, ECO:0000269|PubMed:16888620, ECO:0000269|PubMed:17167223, ECO:0000269|PubMed:18005662, ECO:0000269|PubMed:19293151, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:21865597}.		intracellular signal transduction [GO:0035556]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-binding transcription factor activity [GO:0051090]	cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]	ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; chloride channel regulator activity [GO:0017081]; phosphatidylinositol binding [GO:0035091]; potassium channel regulator activity [GO:0015459]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; sodium channel regulator activity [GO:0017080]	cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; chloride channel regulator activity [GO:0017081]; phosphatidylinositol binding [GO:0035091]; potassium channel regulator activity [GO:0015459]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; sodium channel regulator activity [GO:0017080]; intracellular signal transduction [GO:0035556]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-binding transcription factor activity [GO:0051090]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}. Early endosome. Recycling endosome. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.
Q96BR5	reviewed	COA7_HUMAN	Cytochrome c oxidase assembly factor 7 (Beta-lactamase hcp-like protein) (Respiratory chain assembly factor 1) (Sel1 repeat-containing protein 1)	COA7 C1orf163 RESA1 SELRC1	Homo sapiens (Human)	231	FUNCTION: Required for assembly of mitochondrial respiratory chain complex I and complex IV. {ECO:0000269|PubMed:24333015}.			mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]		mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:24333015, ECO:0000269|PubMed:30885959}. Note=The import in the mitochondrion intermembrane space is mediated by CHCHD4/MIA40. {ECO:0000269|PubMed:30885959}.
Q96BR6	reviewed	ZN669_HUMAN	Zinc finger protein 669	ZNF669	Homo sapiens (Human)	464	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96BR9	reviewed	ZBT8A_HUMAN	Zinc finger and BTB domain-containing protein 8A (BTB/POZ and zinc-finger domain-containing factor) (BTB/POZ and zinc-finger domains factor on chromosome 1) (BOZ-F1)	ZBTB8A BOZF1	Homo sapiens (Human)	441	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96BS2	reviewed	CHP3_HUMAN	Calcineurin B homologous protein 3 (Tescalcin) (TSC)	TESC CHP3	Homo sapiens (Human)	214	FUNCTION: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. {ECO:0000269|PubMed:17717601, ECO:0000269|PubMed:18321853, ECO:0000269|PubMed:20060826}.		cellular response to retinoic acid [GO:0071300]; male gonad development [GO:0008584]; megakaryocyte differentiation [GO:0030219]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of sodium:proton antiporter activity [GO:0032417]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of cell adhesion mediated by integrin [GO:0033628]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; phosphatase inhibitor activity [GO:0019212]; protein homodimerization activity [GO:0042803]; protein kinase inhibitor activity [GO:0004860]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; phosphatase inhibitor activity [GO:0019212]; protein homodimerization activity [GO:0042803]; protein kinase inhibitor activity [GO:0004860]; cellular response to retinoic acid [GO:0071300]; male gonad development [GO:0008584]; megakaryocyte differentiation [GO:0030219]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of sodium:proton antiporter activity [GO:0032417]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of cell adhesion mediated by integrin [GO:0033628]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18321853}. Cytoplasm {ECO:0000269|PubMed:18321853}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:18321853}. Cell projection, lamellipodium {ECO:0000269|PubMed:11696366}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9JKL5}. Note=Colocalizes with SLC9A1 at the plasma membrane. {ECO:0000269|PubMed:18321853}.
Q96BT3	reviewed	CENPT_HUMAN	Centromere protein T (CENP-T) (Interphase centromere complex protein 22)	CENPT C16orf56 ICEN22	Homo sapiens (Human)	561	FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}.		cell division [GO:0051301]; chromosome organization [GO:0051276]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; cell division [GO:0051301]; chromosome organization [GO:0051276]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:19412974}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19412974}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus. {ECO:0000269|PubMed:19412974}.
Q96BT7	reviewed	ALKB8_HUMAN	Alkylated DNA repair protein alkB homolog 8 (Probable alpha-ketoglutarate-dependent dioxygenase ABH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8) (tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8) (EC 2.1.1.229)	ALKBH8 ABH8	Homo sapiens (Human)	664	FUNCTION: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269|PubMed:19293182, ECO:0000269|PubMed:20123966, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:21285950, ECO:0000269|PubMed:31079898}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be due to competing donor splice site. {ECO:0000305}.	DNA damage response [GO:0006974]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity [GO:0106335]; tRNA (uracil) methyltransferase activity [GO:0016300]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity [GO:0106335]; tRNA (uracil) methyltransferase activity [GO:0016300]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; DNA damage response [GO:0006974]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:34948388}. Nucleus {ECO:0000269|PubMed:20308323}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:20308323}.
Q96BW1	reviewed	UPP_HUMAN	Uracil phosphoribosyltransferase homolog	UPRT	Homo sapiens (Human)	309			female pregnancy [GO:0007565]; lactation [GO:0007595]; response to insulin [GO:0032868]; UMP biosynthetic process [GO:0006222]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	GTP binding [GO:0005525]; ribosylnicotinamide kinase activity [GO:0050262]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; GTP binding [GO:0005525]; ribosylnicotinamide kinase activity [GO:0050262]; female pregnancy [GO:0007565]; lactation [GO:0007595]; response to insulin [GO:0032868]; UMP biosynthetic process [GO:0006222]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17384901}. Nucleus {ECO:0000269|PubMed:17384901}.
Q96BW9	reviewed	TAM41_HUMAN	Phosphatidate cytidylyltransferase, mitochondrial (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (Mitochondrial translocator assembly and maintenance protein 41 homolog) (TAM41)	TAMM41 C3orf31	Homo sapiens (Human)	452	FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol. {ECO:0000250|UniProtKB:D3ZKT0}.		cardiolipin biosynthetic process [GO:0032049]; CDP-diacylglycerol biosynthetic process [GO:0016024]	extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	phosphatidate cytidylyltransferase activity [GO:0004605]	extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; phosphatidate cytidylyltransferase activity [GO:0004605]; cardiolipin biosynthetic process [GO:0032049]; CDP-diacylglycerol biosynthetic process [GO:0016024]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:D3ZKT0}; Peripheral membrane protein {ECO:0000250|UniProtKB:D3ZKT0}; Matrix side {ECO:0000250|UniProtKB:P53230}.
Q96BY2	reviewed	MOAP1_HUMAN	Modulator of apoptosis 1 (MAP-1) (MAP1) (Paraneoplastic antigen Ma4)	MOAP1 PNMA4	Homo sapiens (Human)	351	FUNCTION: Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (PubMed:11060313, PubMed:16199525). Required for death receptor-dependent apoptosis (PubMed:11060313). When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (PubMed:15949439). Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins (PubMed:33783314). Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (PubMed:33393215). {ECO:0000250|UniProtKB:Q9ERH6, ECO:0000269|PubMed:11060313, ECO:0000269|PubMed:15949439, ECO:0000269|PubMed:16199525, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33783314}.		apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:0001844]; regulation of apoptotic process [GO:0042981]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; ubiquitin protein ligase binding [GO:0031625]; apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:0001844]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19100260}. Mitochondrion outer membrane {ECO:0000269|PubMed:16199525}. Extracellular vesicle membrane {ECO:0000250|UniProtKB:Q9ERH6}. Note=Forms virion-like extracellular vesicles that are released from cells. {ECO:0000250|UniProtKB:Q9ERH6}.
Q96BY6	reviewed	DOC10_HUMAN	Dedicator of cytokinesis protein 10 (Zizimin-3)	DOCK10 KIAA0694 ZIZ3	Homo sapiens (Human)	2186	FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}.	MISCELLANEOUS: 'Zizim' means 'spike' in Hebrew. {ECO:0000305}.	B cell homeostasis [GO:0001782]; dendritic spine morphogenesis [GO:0060997]; marginal zone B cell differentiation [GO:0002315]; positive regulation of GTPase activity [GO:0043547]; regulation of cell migration [GO:0030334]; small GTPase mediated signal transduction [GO:0007264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; B cell homeostasis [GO:0001782]; dendritic spine morphogenesis [GO:0060997]; marginal zone B cell differentiation [GO:0002315]; positive regulation of GTPase activity [GO:0043547]; regulation of cell migration [GO:0030334]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18499258}. Cytoplasm {ECO:0000269|PubMed:18499258}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q8BZN6}.
Q96BY7	reviewed	ATG2B_HUMAN	Autophagy-related protein 2 homolog B	ATG2B C14orf103	Homo sapiens (Human)	2078	FUNCTION: Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}.		autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; late nucleophagy [GO:0044805]; piecemeal microautophagy of the nucleus [GO:0034727]; reticulophagy [GO:0061709]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]	lipid transfer activity [GO:0120013]; phosphatidylinositol-3-phosphate binding [GO:0032266]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; lipid transfer activity [GO:0120013]; phosphatidylinositol-3-phosphate binding [GO:0032266]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; late nucleophagy [GO:0044805]; piecemeal microautophagy of the nucleus [GO:0034727]; reticulophagy [GO:0061709]	SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000269|PubMed:22219374}; Peripheral membrane protein {ECO:0000269|PubMed:22219374}. Lipid droplet {ECO:0000269|PubMed:22219374}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P53855}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53855}.
Q96BY9	reviewed	SARAF_HUMAN	Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (HBV X-transactivated gene 3 protein) (HBV XAg-transactivated protein 3) (Protein FOAP-7) (Transmembrane protein 66)	SARAF TMEM66 XTP3 HSPC035 NPD003 PSEC0019 UNQ1967/PRO4499	Homo sapiens (Human)	339	FUNCTION: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. {ECO:0000269|PubMed:22464749}.		calcium ion transport [GO:0006816]; regulation of store-operated calcium entry [GO:2001256]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; calcium ion transport [GO:0006816]; regulation of store-operated calcium entry [GO:2001256]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22464749}; Single-pass type I membrane protein {ECO:0000269|PubMed:22464749}. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Q96BZ4	reviewed	PLD4_HUMAN	5'-3' exonuclease PLD4 (EC 3.1.16.1) (Choline phosphatase 4) (Phosphatidylcholine-hydrolyzing phospholipase D4) (Phospholipase D family member 4) (Phospholipase D4) (PLD 4)	PLD4 C14orf175 UNQ2488/PRO5775	Homo sapiens (Human)	506	FUNCTION: 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia. {ECO:0000250|UniProtKB:Q8BG07}.		establishment of localization in cell [GO:0051649]; hematopoietic progenitor cell differentiation [GO:0002244]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; phagocytosis [GO:0006909]; regulation of cytokine production involved in inflammatory response [GO:1900015]	early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; trans-Golgi network membrane [GO:0032588]	single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]	early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; trans-Golgi network membrane [GO:0032588]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]; establishment of localization in cell [GO:0051649]; hematopoietic progenitor cell differentiation [GO:0002244]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; phagocytosis [GO:0006909]; regulation of cytokine production involved in inflammatory response [GO:1900015]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BG07}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8BG07}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q8BG07}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8BG07}. Nucleus {ECO:0000250|UniProtKB:Q8BG07}. Early endosome {ECO:0000250|UniProtKB:Q8BG07}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q8BG07}. Note=Activation of microglia induces translocation of PLD4 from the nucleus to the phagosomes. {ECO:0000250|UniProtKB:Q8BG07}.
Q96BZ8	reviewed	LENG1_HUMAN	Leukocyte receptor cluster member 1	LENG1	Homo sapiens (Human)	264		MISCELLANEOUS: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.		nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	
Q96BZ9	reviewed	TBC20_HUMAN	TBC1 domain family member 20	TBC1D20 C20orf140	Homo sapiens (Human)	403	FUNCTION: GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude (PubMed:23236136). Involved in maintaining endoplasmic reticulum structure (PubMed:24891604). {ECO:0000269|PubMed:23236136, ECO:0000269|PubMed:24891604}.	MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.	acrosome assembly [GO:0001675]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; lens fiber cell morphogenesis [GO:0070309]; lipid droplet organization [GO:0034389]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of GTPase activity [GO:0043547]; seminiferous tubule development [GO:0072520]; virion assembly [GO:0019068]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; acrosome assembly [GO:0001675]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; lens fiber cell morphogenesis [GO:0070309]; lipid droplet organization [GO:0034389]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of GTPase activity [GO:0043547]; seminiferous tubule development [GO:0072520]; virion assembly [GO:0019068]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96C00	reviewed	ZBTB9_HUMAN	Zinc finger and BTB domain-containing protein 9	ZBTB9	Homo sapiens (Human)	473	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96C03	reviewed	MID49_HUMAN	Mitochondrial dynamics protein MID49 (Mitochondrial dynamics protein of 49 kDa) (Mitochondrial elongation factor 2) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein)	MIEF2 MID49 SMCR7	Homo sapiens (Human)	454	FUNCTION: Mitochondrial outer membrane protein involved in the regulation of mitochondrial organization (PubMed:29361167). It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:29361167, ECO:0000269|PubMed:29899447}.	MISCELLANEOUS: Does not bind ADP or other nucleotides, in contrast to MIEF1. {ECO:0000250}.	mitochondrion organization [GO:0007005]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of mitochondrion organization [GO:0010821]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; mitochondrion organization [GO:0007005]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of mitochondrion organization [GO:0010821]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:21508961}; Single-pass membrane protein {ECO:0000269|PubMed:21508961}. Note=Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria.
Q96C10	reviewed	DHX58_HUMAN	ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR)	DHX58 D11LGP2E LGP2	Homo sapiens (Human)	678	FUNCTION: Acts as a regulator of RIGI and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to RIGI and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on RIG-I signaling may involve the following mechanisms: competition with RIGI for binding to the viral RNA, binding to RIGI and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by RIGI and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes (PubMed:31256877). Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate. {ECO:0000269|PubMed:16116171, ECO:0000269|PubMed:17020950, ECO:0000269|PubMed:17190814, ECO:0000269|PubMed:18411269, ECO:0000269|PubMed:19208642, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19278996, ECO:0000269|PubMed:19380577, ECO:0000269|PubMed:21187438, ECO:0000269|PubMed:21525357, ECO:0000269|PubMed:31256877}.		antiviral innate immune response [GO:0140374]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; negative regulation of innate immune response [GO:0045824]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; regulation of innate immune response [GO:0045088]; response to bacterium [GO:0009617]; response to virus [GO:0009615]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]; antiviral innate immune response [GO:0140374]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; negative regulation of innate immune response [GO:0045824]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; regulation of innate immune response [GO:0045088]; response to bacterium [GO:0009617]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19380577}.
Q96C11	reviewed	FGGY_HUMAN	FGGY carbohydrate kinase domain-containing protein (D-ribulokinase FGGY) (EC 2.7.1.47)	FGGY	Homo sapiens (Human)	551	FUNCTION: Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway. Can phosphorylate ribitol with low efficiency. {ECO:0000269|PubMed:27909055}.		carbohydrate phosphorylation [GO:0046835]; neuron cellular homeostasis [GO:0070050]; pentose metabolic process [GO:0019321]	cytoplasm [GO:0005737]	D-ribulokinase activity [GO:0019150]	cytoplasm [GO:0005737]; D-ribulokinase activity [GO:0019150]; carbohydrate phosphorylation [GO:0046835]; neuron cellular homeostasis [GO:0070050]; pentose metabolic process [GO:0019321]	
Q96C12	reviewed	ARMC5_HUMAN	Armadillo repeat-containing protein 5	ARMC5	Homo sapiens (Human)	935	FUNCTION: Involved in fetal development, T-cell function and adrenal gland growth homeostasis (By similarity). Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). {ECO:0000250|UniProtKB:Q5EBP3, ECO:0000269|PubMed:24283224, ECO:0000269|PubMed:28676429}.		adrenal cortex development [GO:0035801]; anatomical structure morphogenesis [GO:0009653]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; defense response to virus [GO:0051607]; in utero embryonic development [GO:0001701]; mesoderm formation [GO:0001707]; regulation of steroid biosynthetic process [GO:0050810]; T cell proliferation [GO:0042098]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; adrenal cortex development [GO:0035801]; anatomical structure morphogenesis [GO:0009653]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; defense response to virus [GO:0051607]; in utero embryonic development [GO:0001701]; mesoderm formation [GO:0001707]; regulation of steroid biosynthetic process [GO:0050810]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24283224}.
Q96C23	reviewed	GALM_HUMAN	Galactose mutarotase (EC 5.1.3.3) (Aldose 1-epimerase)	GALM BLOCK25	Homo sapiens (Human)	342	FUNCTION: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism (PubMed:12753898). Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase) (PubMed:30451973). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1 (PubMed:12753898). Also active on D-glucose although shows a preference for galactose over glucose (PubMed:12753898). {ECO:0000269|PubMed:12753898, ECO:0000269|PubMed:30451973}.		carbohydrate metabolic process [GO:0005975]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012]; glucose metabolic process [GO:0006006]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246]; carbohydrate metabolic process [GO:0005975]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012]; glucose metabolic process [GO:0006006]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q96C24	reviewed	SYTL4_HUMAN	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin)	SYTL4	Homo sapiens (Human)	671	FUNCTION: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	exocytosis [GO:0006887]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; multivesicular body sorting pathway [GO:0071985]; negative regulation of insulin secretion [GO:0046676]; plasma membrane repair [GO:0001778]; positive regulation of exocytosis [GO:0045921]; positive regulation of protein secretion [GO:0050714]; regulation of plasma membrane repair [GO:1905684]	endosome [GO:0005768]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; transport vesicle membrane [GO:0030658]	metal ion binding [GO:0046872]; neurexin family protein binding [GO:0042043]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]	endosome [GO:0005768]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; transport vesicle membrane [GO:0030658]; metal ion binding [GO:0046872]; neurexin family protein binding [GO:0042043]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; multivesicular body sorting pathway [GO:0071985]; negative regulation of insulin secretion [GO:0046676]; plasma membrane repair [GO:0001778]; positive regulation of exocytosis [GO:0045921]; positive regulation of protein secretion [GO:0050714]; regulation of plasma membrane repair [GO:1905684]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity). {ECO:0000250}.
Q96C36	reviewed	P5CR2_HUMAN	Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2)	PYCR2	Homo sapiens (Human)	320	FUNCTION: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492). {ECO:0000269|PubMed:25865492, ECO:0000269|PubMed:2722838, ECO:0000269|PubMed:6894153}.		cellular response to oxidative stress [GO:0034599]; L-proline biosynthetic process [GO:0055129]; proline biosynthetic process [GO:0006561]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	pyrroline-5-carboxylate reductase activity [GO:0004735]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyrroline-5-carboxylate reductase activity [GO:0004735]; cellular response to oxidative stress [GO:0034599]; L-proline biosynthetic process [GO:0055129]; proline biosynthetic process [GO:0006561]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:2722838}. Mitochondrion {ECO:0000269|PubMed:23024808, ECO:0000269|PubMed:25865492}.
Q96C45	reviewed	ULK4_HUMAN	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4)	ULK4	Homo sapiens (Human)	1275	FUNCTION: May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility. {ECO:0000269|PubMed:24284070}.		microtubule cytoskeleton organization [GO:0000226]; phosphorylation [GO:0016310]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408]; regulation of neuron migration [GO:2001222]; regulation of neuron projection development [GO:0010975]; regulation of p38MAPK cascade [GO:1900744]; regulation of protein kinase C signaling [GO:0090036]		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; microtubule cytoskeleton organization [GO:0000226]; phosphorylation [GO:0016310]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408]; regulation of neuron migration [GO:2001222]; regulation of neuron projection development [GO:0010975]; regulation of p38MAPK cascade [GO:1900744]; regulation of protein kinase C signaling [GO:0090036]	
Q96C55	reviewed	ZN524_HUMAN	Zinc finger protein 524	ZNF524	Homo sapiens (Human)	264	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96C74	reviewed	ROP1L_HUMAN	Ropporin-1-like protein (ROPN1-like protein) (AKAP-associated sperm protein)	ROPN1L ASP RSPH11	Homo sapiens (Human)	230	FUNCTION: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. {ECO:0000250|UniProtKB:Q9EQ00}.		epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; regulation of protein phosphorylation [GO:0001932]; sperm capacitation [GO:0048240]	cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; motile cilium [GO:0031514]	identical protein binding [GO:0042802]	cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; identical protein binding [GO:0042802]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; regulation of protein phosphorylation [GO:0001932]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9EQ00}. Cell projection, cilium {ECO:0000269|PubMed:27120127}.
Q96C86	reviewed	DCPS_HUMAN	m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS)	DCPS DCS1 HINT5 HSPC015	Homo sapiens (Human)	337	FUNCTION: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death. {ECO:0000269|PubMed:11747811, ECO:0000269|PubMed:12198172, ECO:0000269|PubMed:12871939, ECO:0000269|PubMed:14523240, ECO:0000269|PubMed:15273322, ECO:0000269|PubMed:15383679, ECO:0000269|PubMed:15769464, ECO:0000269|PubMed:16140270, ECO:0000269|PubMed:18426921, ECO:0000269|PubMed:22985415}.		deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; methylguanosine-cap decapping [GO:0110156]; mRNA cis splicing, via spliceosome [GO:0045292]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity [GO:0140932]; identical protein binding [GO:0042802]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA exonuclease activity [GO:0004532]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity [GO:0140932]; identical protein binding [GO:0042802]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA exonuclease activity [GO:0004532]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; methylguanosine-cap decapping [GO:0110156]; mRNA cis splicing, via spliceosome [GO:0045292]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner.
Q96C92	reviewed	ENTR1_HUMAN	Endosome-associated-trafficking regulator 1 (Antigen NY-CO-3) (Serologically defined colon cancer antigen 3)	ENTR1 SDCCAG3	Homo sapiens (Human)	435	FUNCTION: Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:A2AIW0, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25278552, ECO:0000269|PubMed:27767179}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cell projection organization [GO:0030030]; endocytic recycling [GO:0032456]; positive regulation of cilium assembly [GO:0045724]; positive regulation of protein localization to cilium [GO:1903566]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; early endosome [GO:0005769]; endosome [GO:0005768]; midbody [GO:0030496]; recycling endosome [GO:0055037]		centrosome [GO:0005813]; ciliary basal body [GO:0036064]; early endosome [GO:0005769]; endosome [GO:0005768]; midbody [GO:0030496]; recycling endosome [GO:0055037]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell projection organization [GO:0030030]; endocytic recycling [GO:0032456]; positive regulation of cilium assembly [GO:0045724]; positive regulation of protein localization to cilium [GO:1903566]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2AIW0}. Early endosome {ECO:0000269|PubMed:23108400}. Endosome {ECO:0000269|PubMed:25278552}. Recycling endosome {ECO:0000269|PubMed:23108400}. Midbody {ECO:0000269|PubMed:23108400}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:27767179}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27767179}. Note=Colocalizes in a WASHC2-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552). During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400). Colocalizes with IFT88 and gamma-tubulin at the basal body of primary cilia (PubMed:27767179). Colocalizes with IFT88 and pericentrin at the centrosome (PubMed:27767179). {ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25278552, ECO:0000269|PubMed:27767179}.
Q96CA5	reviewed	BIRC7_HUMAN	Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)]	BIRC7 KIAP LIVIN MLIAP RNF50 UNQ5800/PRO19607/PRO21344	Homo sapiens (Human)	298	FUNCTION: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control (PubMed:11162435, PubMed:11024045, PubMed:11084335, PubMed:16729033, PubMed:17294084). Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity (PubMed:11024045, PubMed:16729033). As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival (PubMed:16729033). May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions (PubMed:16729033). Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine (PubMed:11162435, PubMed:11084335, PubMed:11865055). Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2 (PubMed:11865055). This activation depends on TAB1 and MAP3K7/TAK1 (PubMed:11865055). In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9 (PubMed:11024045). {ECO:0000269|PubMed:11024045, ECO:0000269|PubMed:11084335, ECO:0000269|PubMed:11162435, ECO:0000269|PubMed:11865055, ECO:0000269|PubMed:16729033, ECO:0000269|PubMed:17294084}.; FUNCTION: [Isoform 1]: Blocks staurosporine-induced apoptosis (PubMed:11322947). Promotes natural killer (NK) cell-mediated killing (PubMed:18034418). {ECO:0000269|PubMed:11322947, ECO:0000269|PubMed:18034418}.; FUNCTION: [Isoform 2]: Blocks etoposide-induced apoptosis (PubMed:11162435, PubMed:11322947). Protects against natural killer (NK) cell-mediated killing (PubMed:18034418). {ECO:0000269|PubMed:11162435, ECO:0000269|PubMed:11322947, ECO:0000269|PubMed:18034418}.		apoptotic process [GO:0006915]; lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of natural killer cell apoptotic process [GO:0070247]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of natural killer cell apoptotic process [GO:0070247]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17294084}. Cytoplasm {ECO:0000269|PubMed:17294084}. Golgi apparatus {ECO:0000269|PubMed:17294084}. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
Q96CB8	reviewed	INT12_HUMAN	Integrator complex subunit 12 (Int12) (PHD finger protein 22)	INTS12 PHF22 SBBI22	Homo sapiens (Human)	462	FUNCTION: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267}.		regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]	integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23904267}.
Q96CB9	reviewed	NSUN4_HUMAN	5-methylcytosine rRNA methyltransferase NSUN4 (EC 2.1.1.-) (5-methylcytosine tRNA methyltransferase NSUN4) (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 4)	NSUN4	Homo sapiens (Human)	384	FUNCTION: Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4. {ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:23022348}.		rRNA methylation [GO:0031167]	mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]	methyltransferase activity [GO:0008168]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383]; rRNA binding [GO:0019843]	mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; methyltransferase activity [GO:0008168]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383]; rRNA binding [GO:0019843]; rRNA methylation [GO:0031167]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:22949673, ECO:0000269|PubMed:23022348}.
Q96CC6	reviewed	RHDF1_HUMAN	Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho)	RHBDF1 C16orf8 DIST1 IRHOM1	Homo sapiens (Human)	855	FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}.		cell migration [GO:0016477]; cell population proliferation [GO:0008283]; negative regulation of protein secretion [GO:0050709]; protein transport [GO:0015031]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein secretion [GO:0050708]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	growth factor binding [GO:0019838]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; growth factor binding [GO:0019838]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; negative regulation of protein secretion [GO:0050709]; protein transport [GO:0015031]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein secretion [GO:0050708]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18832597}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localized in the endoplasmic reticulum membrane (PubMed:15965977). {ECO:0000269|PubMed:15965977}.
Q96CD2	reviewed	COAC_HUMAN	Phosphopantothenoylcysteine decarboxylase (PPC-DC) (EC 4.1.1.36) (CoaC)	PPCDC COAC MDS018 UNQ9365/PRO34154	Homo sapiens (Human)	204	FUNCTION: Catalyzes the decarboxylation of the cysteine moiety of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:15581364}.	MISCELLANEOUS: [Isoform 2]: The Met-1 codon is associated with a polymorphism (dbSNP:rs2304899) that replaces the initiation ATG codon by an ATA codon. {ECO:0000305}.	coenzyme A biosynthetic process [GO:0015937]	cytosol [GO:0005829]; phosphopantothenoylcysteine decarboxylase complex [GO:0071513]	FMN binding [GO:0010181]; identical protein binding [GO:0042802]; phosphopantothenoylcysteine decarboxylase activity [GO:0004633]	cytosol [GO:0005829]; phosphopantothenoylcysteine decarboxylase complex [GO:0071513]; FMN binding [GO:0010181]; identical protein binding [GO:0042802]; phosphopantothenoylcysteine decarboxylase activity [GO:0004633]; coenzyme A biosynthetic process [GO:0015937]	
Q96CE8	reviewed	T4S18_HUMAN	Transmembrane 4 L6 family member 18	TM4SF18	Homo sapiens (Human)	201				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96CF2	reviewed	CHM4C_HUMAN	Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (SNF7 homolog associated with Alix 3) (SNF7-3) (hSnf7-3) (Vacuolar protein sorting-associated protein 32-3) (Vps32-3) (hVps32-3)	CHMP4C SHAX3	Homo sapiens (Human)	233	FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission (PubMed:22422861, PubMed:24814515). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515}.	MISCELLANEOUS: Its overexpression strongly inhibits HIV-1 release.	abscission [GO:0009838]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of cytokinesis [GO:0032466]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; Flemming body [GO:0090543]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]	protein homodimerization activity [GO:0042803]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; Flemming body [GO:0090543]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]; abscission [GO:0009838]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of cytokinesis [GO:0032466]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Late endosome membrane {ECO:0000305|PubMed:14583093}; Peripheral membrane protein {ECO:0000305}. Midbody, Midbody ring {ECO:0000269|PubMed:22422861}. Note=Localizes to the midbody during late cytokinesis. During its recruitment, localizes initially to the midbody arms, before being directed to the central region, the midbody ring, also called Flemming body. Phosphorylation at Ser-210 by AURKB triggers localization to midbody ring. {ECO:0000269|PubMed:22422861}.
Q96CG3	reviewed	TIFA_HUMAN	TRAF-interacting protein with FHA domain-containing protein A (Putative MAPK-activating protein PM14) (Putative NF-kappa-B-activating protein 20) (TRAF2-binding protein)	TIFA T2BP	Homo sapiens (Human)	184	FUNCTION: Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (PubMed:12566447, PubMed:15492226, PubMed:26068852, PubMed:28877472, PubMed:28222186, PubMed:30111836). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (PubMed:15492226, PubMed:26068852). TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling (PubMed:30111836). {ECO:0000269|PubMed:12566447, ECO:0000269|PubMed:15492226, ECO:0000269|PubMed:26068852, ECO:0000269|PubMed:28222186, ECO:0000269|PubMed:28877472, ECO:0000269|PubMed:30111836}.		canonical NF-kappaB signal transduction [GO:0007249]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein homooligomerization [GO:0051260]	cytoplasm [GO:0005737]; cytosol [GO:0005829]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; canonical NF-kappaB signal transduction [GO:0007249]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22566686, ECO:0000305|PubMed:26068852}. Note=Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation. {ECO:0000269|PubMed:26068852}.
Q96CG8	reviewed	CTHR1_HUMAN	Collagen triple helix repeat-containing protein 1	CTHRC1 UNQ762/PRO1550	Homo sapiens (Human)	243	FUNCTION: May act as a negative regulator of collagen matrix deposition. {ECO:0000250}.		cochlea morphogenesis [GO:0090103]; establishment of planar polarity involved in neural tube closure [GO:0090177]; inner ear receptor cell stereocilium organization [GO:0060122]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; ossification involved in bone remodeling [GO:0043932]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; sarcoplasm [GO:0016528]	frizzled binding [GO:0005109]; Wnt-protein binding [GO:0017147]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; sarcoplasm [GO:0016528]; frizzled binding [GO:0005109]; Wnt-protein binding [GO:0017147]; cochlea morphogenesis [GO:0090103]; establishment of planar polarity involved in neural tube closure [GO:0090177]; inner ear receptor cell stereocilium organization [GO:0060122]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; ossification involved in bone remodeling [GO:0043932]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q96CJ1	reviewed	EAF2_HUMAN	ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein)	EAF2 TRAITS BM-040	Homo sapiens (Human)	260	FUNCTION: Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo. {ECO:0000250, ECO:0000269|PubMed:12446457, ECO:0000269|PubMed:12907652, ECO:0000269|PubMed:16006523}.		apoptotic process [GO:0006915]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023]	transcription elongation factor activity [GO:0003711]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023]; transcription elongation factor activity [GO:0003711]; apoptotic process [GO:0006915]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:12446457, ECO:0000269|PubMed:12907652}.
Q96CK0	reviewed	ZN653_HUMAN	Zinc finger protein 653 (67 kDa zinc finger protein) (Zinc finger protein Zip67)	ZNF653 ZIP67	Homo sapiens (Human)	615	FUNCTION: Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity. {ECO:0000269|PubMed:12920234}.		extracellular negative regulation of signal transduction [GO:1900116]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	extracellular region [GO:0005576]; nucleus [GO:0005634]	AF-2 domain binding [GO:0050682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]	extracellular region [GO:0005576]; nucleus [GO:0005634]; AF-2 domain binding [GO:0050682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; extracellular negative regulation of signal transduction [GO:1900116]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96CM3	reviewed	RUSD4_HUMAN	Pseudouridylate synthase RPUSD4, mitochondrial (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 4)	RPUSD4	Homo sapiens (Human)	377	FUNCTION: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates (PubMed:27974379, PubMed:28082677). Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA) (PubMed:27974379). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Acts on position 39 in mitochondrial tRNA(Phe) (PubMed:28082677). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677, ECO:0000269|PubMed:35051350}.		mitochondrial tRNA pseudouridine synthesis [GO:0070902]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of mitochondrial translation [GO:0070131]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein granule [GO:0035770]	mitochondrial ribosomal large subunit rRNA binding [GO:1990400]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein granule [GO:0035770]; mitochondrial ribosomal large subunit rRNA binding [GO:1990400]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]; mitochondrial tRNA pseudouridine synthesis [GO:0070902]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of mitochondrial translation [GO:0070131]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:23435261, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677}. Nucleus {ECO:0000269|PubMed:23435261}. Cytoplasm {ECO:0000269|PubMed:23435261}. Note=Mainly localizes to mitochondrion (PubMed:23435261, PubMed:27974379, PubMed:28082677). Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly (PubMed:27974379, PubMed:28082677). Also found in nucleus and cytoplasm (PubMed:23435261). {ECO:0000269|PubMed:23435261, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677}.
Q96CM8	reviewed	ACSF2_HUMAN	Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2)	ACSF2 UNQ493/PRO1009	Homo sapiens (Human)	615	FUNCTION: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed:17762044). Has some preference toward medium-chain substrates (PubMed:17762044). Plays a role in adipocyte differentiation (PubMed:16380219). {ECO:0000269|PubMed:16380219, ECO:0000269|PubMed:17762044}.		acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]	mitochondrial matrix [GO:0005759]	ATP binding [GO:0005524]; butyrate-CoA ligase activity [GO:0047760]; long-chain fatty acid-CoA ligase activity [GO:0004467]; medium-chain fatty acid-CoA ligase activity [GO:0031956]	mitochondrial matrix [GO:0005759]; ATP binding [GO:0005524]; butyrate-CoA ligase activity [GO:0047760]; long-chain fatty acid-CoA ligase activity [GO:0004467]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q96CN4	reviewed	EVI5L_HUMAN	EVI5-like protein (Ecotropic viral integration site 5-like protein)	EVI5L	Homo sapiens (Human)	794	FUNCTION: Functions as a GTPase-activating protein (GAP) with a broad specificity. {ECO:0000269|PubMed:16923123}.		negative regulation of cilium assembly [GO:1902018]; positive regulation of GTPase activity [GO:0043547]		GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; negative regulation of cilium assembly [GO:1902018]; positive regulation of GTPase activity [GO:0043547]	
Q96CN5	reviewed	LRC45_HUMAN	Leucine-rich repeat-containing protein 45	LRRC45	Homo sapiens (Human)	670	FUNCTION: Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. {ECO:0000269|PubMed:24035387}.			centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24035387, ECO:0000269|PubMed:31974111}. Note=Localizes to the proteinaceous linker between the proximal ends of the centrioles. {ECO:0000269|PubMed:24035387}.
Q96CN9	reviewed	GCC1_HUMAN	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1)	GCC1	Homo sapiens (Human)	775	FUNCTION: Probably involved in maintaining Golgi structure.			cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]	small GTPase binding [GO:0031267]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; small GTPase binding [GO:0031267]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10209125}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q96CP6	reviewed	ASTRA_HUMAN	Protein Aster-A (GRAM domain-containing protein 1A)	GRAMD1A KIAA1533	Homo sapiens (Human)	724	FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}.		autophagy [GO:0006914]; cellular response to cholesterol [GO:0071397]; intracellular sterol transport [GO:0032366]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; autophagy [GO:0006914]; cellular response to cholesterol [GO:0071397]; intracellular sterol transport [GO:0032366]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29469807}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:29469807}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:31222192}. Note=In lipid-poor conditions localizes to the ER membrane and is recruited to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM (By similarity). Localizes to distinct EPCS than GRAMD2A and ESYT2/3 (PubMed:29469807). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:29469807}.
Q96CP7	reviewed	TLCD1_HUMAN	TLC domain-containing protein 1 (Calfacilitin)	TLCD1	Homo sapiens (Human)	247	FUNCTION: Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349). {ECO:0000269|PubMed:30509349}.		membrane assembly [GO:0071709]; phospholipid homeostasis [GO:0055091]; plasma membrane organization [GO:0007009]; regulation of membrane lipid distribution [GO:0097035]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; membrane assembly [GO:0071709]; phospholipid homeostasis [GO:0055091]; plasma membrane organization [GO:0007009]; regulation of membrane lipid distribution [GO:0097035]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:30509349}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F1NZP5}.
Q96CQ1	reviewed	S2536_HUMAN	Solute carrier family 25 member 36	SLC25A36	Homo sapiens (Human)	311	FUNCTION: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports cytosine, guanosine, inosine and uridine (deoxy)nucleoside mono-, di-, and triphosphates by antiport mechanism. Catalyzes uniport at much lower rate (PubMed:25320081). May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside mono- and diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. {ECO:0000269|PubMed:25320081}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mitochondrial genome maintenance [GO:0000002]; mitochondrion organization [GO:0007005]; pyrimidine nucleotide import into mitochondrion [GO:1990519]; pyrimidine nucleotide transport [GO:0006864]; regulation of mitochondrial membrane potential [GO:0051881]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	pyrimidine nucleotide transmembrane transporter activity [GO:0015218]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; pyrimidine nucleotide transmembrane transporter activity [GO:0015218]; mitochondrial genome maintenance [GO:0000002]; mitochondrion organization [GO:0007005]; pyrimidine nucleotide import into mitochondrion [GO:1990519]; pyrimidine nucleotide transport [GO:0006864]; regulation of mitochondrial membrane potential [GO:0051881]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:25320081}; Multi-pass membrane protein {ECO:0000255}.
Q96CS2	reviewed	HAUS1_HUMAN	HAUS augmin-like complex subunit 1 (Coiled-coil domain-containing protein 5) (Enhancer of invasion-cluster) (HEI-C)	HAUS1 CCDC5 HEIC	Homo sapiens (Human)	278	FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:15082789, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.	MISCELLANEOUS: HAUS1-depleted cells retain functional cell cycle checkpoints, but the depletion decreases the G2/M cell cycle compartment and induces apoptosis. The protein level remains constant through the cell cycle.	cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; spindle pole [GO:0000922]		centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; spindle pole [GO:0000922]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15082789, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000305|PubMed:19369198}. Note=Localizes with the spindle poles in mitotic cells. In metaphase, localizes to the mitotic asters and is highly punctate on the microtubule array. During later stages of mitosis, remains on the spindle but is not present at the interzone, and is finally observed at the microtubule bundles proximal to the midbody, clearly excluded from the midbody. In contrast, does not colocalize with the tubulin cytoskeleton in interphase cells. In interphase, localized at the centrosome and diffusely in the cytoplasm. Localizes to mitotic spindle microtubules. {ECO:0000269|PubMed:15082789, ECO:0000269|PubMed:30723163}.
Q96CS3	reviewed	FAF2_HUMAN	FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8)	FAF2 ETEA KIAA0887 UBXD8 UBXN3B	Homo sapiens (Human)	445	FUNCTION: Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223). Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly (PubMed:34739333). {ECO:0000269|PubMed:18711132, ECO:0000269|PubMed:23297223, ECO:0000269|PubMed:24215460, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:34739333}.	MISCELLANEOUS: Up-regulated in T-cells and eosinophils from patients with atopic dermatitis.	lipid droplet organization [GO:0034389]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	lipase binding [GO:0035473]; lipase inhibitor activity [GO:0055102]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; lipase binding [GO:0035473]; lipase inhibitor activity [GO:0055102]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; lipid droplet organization [GO:0034389]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12372427}. Lipid droplet {ECO:0000269|PubMed:19773358, ECO:0000269|PubMed:23297223}. Endoplasmic reticulum {ECO:0000269|PubMed:18711132, ECO:0000269|PubMed:23297223, ECO:0000269|PubMed:34739333}.
Q96CS7	reviewed	PKHB2_HUMAN	Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2)	PLEKHB2 EVT2	Homo sapiens (Human)	222	FUNCTION: Involved in retrograde transport of recycling endosomes. {ECO:0000269|PubMed:21911378, ECO:0000269|PubMed:22281740}.		regulation of cell differentiation [GO:0045595]	recycling endosome membrane [GO:0055038]	phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]	recycling endosome membrane [GO:0055038]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; regulation of cell differentiation [GO:0045595]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:21911378, ECO:0000269|PubMed:22281740}; Peripheral membrane protein {ECO:0000269|PubMed:21911378, ECO:0000269|PubMed:22281740}. Note=Specifically detected in tubulovesicular structures, and colocalizes with TFNR.
Q96CT7	reviewed	CC124_HUMAN	Coiled-coil domain-containing protein 124	CCDC124	Homo sapiens (Human)	223	FUNCTION: Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage (PubMed:32687489). Also required for proper progression of late cytokinetic stages (PubMed:23894443). {ECO:0000269|PubMed:23894443, ECO:0000269|PubMed:32687489}.		cell cycle [GO:0007049]; cell division [GO:0051301]; transcription by RNA polymerase II [GO:0006366]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; cell cycle [GO:0007049]; cell division [GO:0051301]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23894443}. Midbody {ECO:0000269|PubMed:23894443}. Note=Colocalizes with gamma-tubulin at interphase, prophase, metaphase, and anaphase. Relocates from centrosome to midbody at telophase.
Q96CU9	reviewed	FXRD1_HUMAN	FAD-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-)	FOXRED1 FP634	Homo sapiens (Human)	486	FUNCTION: Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554). {ECO:0000269|PubMed:20858599, ECO:0000269|PubMed:25678554}.		mitochondrial respiratory chain complex I assembly [GO:0032981]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	oxidoreductase activity [GO:0016491]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; oxidoreductase activity [GO:0016491]; mitochondrial respiratory chain complex I assembly [GO:0032981]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:20858599, ECO:0000305|PubMed:25678554}; Single-pass membrane protein {ECO:0000255}. Note=According to a report, it is associated with the matrix face of the mitochondrial inner membrane and does not contain any transmembrane region. However, one transmembrane domain is clearly predicted by different methods (Probable). {ECO:0000305|PubMed:25678554}.
Q96CV9	reviewed	OPTN_HUMAN	Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)	OPTN FIP2 GLC1E HIP7 HYPL NRP	Homo sapiens (Human)	577	FUNCTION: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:9488477, PubMed:27538435). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}.		autophagy [GO:0006914]; cell death [GO:0008219]; cellular response to unfolded protein [GO:0034620]; defense response to Gram-negative bacterium [GO:0050829]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi to plasma membrane protein transport [GO:0043001]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of receptor recycling [GO:0001920]; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:0061734]; positive regulation of autophagy [GO:0010508]; positive regulation of xenophagy [GO:1904417]; protein localization to Golgi apparatus [GO:0034067]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]	identical protein binding [GO:0042802]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-macromolecule adaptor activity [GO:0030674]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; identical protein binding [GO:0042802]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-macromolecule adaptor activity [GO:0030674]; autophagy [GO:0006914]; cell death [GO:0008219]; cellular response to unfolded protein [GO:0034620]; defense response to Gram-negative bacterium [GO:0050829]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi to plasma membrane protein transport [GO:0043001]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of receptor recycling [GO:0001920]; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:0061734]; positive regulation of autophagy [GO:0010508]; positive regulation of xenophagy [GO:1904417]; protein localization to Golgi apparatus [GO:0034067]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Golgi apparatus {ECO:0000269|PubMed:10807909, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome {ECO:0000269|PubMed:20085643}. Note=Found in the perinuclear region and associates with the Golgi apparatus (PubMed:27534431). Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy. {ECO:0000269|PubMed:27534431}.
Q96CW1	reviewed	AP2M1_HUMAN	AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)	AP2M1 CLAPM1 KIAA0109	Homo sapiens (Human)	435	FUNCTION: Component of the adaptor protein complex 2 (AP-2) (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (PubMed:16581796). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (By similarity). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (PubMed:19033387). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (By similarity). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (PubMed:11877457). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (PubMed:11877457). Plays a role in endocytosis of frizzled family members upon Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P84092, ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:12694563, ECO:0000269|PubMed:12952941, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:16581796, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:31104773}.		clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of receptor internalization [GO:0002092]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; protein-containing complex assembly [GO:0065003]; receptor internalization [GO:0031623]; regulation of vesicle size [GO:0097494]; synaptic vesicle endocytosis [GO:0048488]; vesicle budding from membrane [GO:0006900]; vesicle-mediated transport [GO:0016192]	AP-2 adaptor complex [GO:0030122]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; extracellular exosome [GO:0070062]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	clathrin adaptor activity [GO:0035615]; disordered domain specific binding [GO:0097718]; lipid binding [GO:0008289]; low-density lipoprotein particle receptor binding [GO:0050750]; signal sequence binding [GO:0005048]; transmembrane transporter binding [GO:0044325]	AP-2 adaptor complex [GO:0030122]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; extracellular exosome [GO:0070062]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; clathrin adaptor activity [GO:0035615]; disordered domain specific binding [GO:0097718]; lipid binding [GO:0008289]; low-density lipoprotein particle receptor binding [GO:0050750]; signal sequence binding [GO:0005048]; transmembrane transporter binding [GO:0044325]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of receptor internalization [GO:0002092]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; protein-containing complex assembly [GO:0065003]; receptor internalization [GO:0031623]; regulation of vesicle size [GO:0097494]; synaptic vesicle endocytosis [GO:0048488]; vesicle budding from membrane [GO:0006900]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31104773}. Membrane, coated pit {ECO:0000269|PubMed:31104773}; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250|UniProtKB:P84091}.
Q96CW5	reviewed	GCP3_HUMAN	Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98)	TUBGCP3 GCP3	Homo sapiens (Human)	907	FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.		cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; single fertilization [GO:0007338]; spindle assembly [GO:0051225]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; membrane [GO:0016020]; polar microtubule [GO:0005827]; spindle [GO:0005819]	gamma-tubulin binding [GO:0043015]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; membrane [GO:0016020]; polar microtubule [GO:0005827]; spindle [GO:0005819]; gamma-tubulin binding [GO:0043015]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; single fertilization [GO:0007338]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}.
Q96CW9	reviewed	NTNG2_HUMAN	Netrin-G2 (Laminet-2)	NTNG2 KIAA1857 LMNT2 UNQ9381/PRO34206	Homo sapiens (Human)	530	FUNCTION: Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. {ECO:0000269|PubMed:21946559}.		axonogenesis [GO:0007409]; modulation of chemical synaptic transmission [GO:0050804]; postsynaptic specialization assembly [GO:0098698]; regulation of neuron migration [GO:2001222]; regulation of neuron projection arborization [GO:0150011]; regulation of neuron projection development [GO:0010975]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]	axon [GO:0030424]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; side of membrane [GO:0098552]		axon [GO:0030424]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; side of membrane [GO:0098552]; axonogenesis [GO:0007409]; modulation of chemical synaptic transmission [GO:0050804]; postsynaptic specialization assembly [GO:0098698]; regulation of neuron migration [GO:2001222]; regulation of neuron projection arborization [GO:0150011]; regulation of neuron projection development [GO:0010975]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21946559, ECO:0000269|PubMed:31668703}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:21946559}; Extracellular side {ECO:0000269|PubMed:21946559, ECO:0000269|PubMed:31668703}.
Q96D03	reviewed	DDT4L_HUMAN	DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2)	DDIT4L REDD2 RTP801L	Homo sapiens (Human)	193	FUNCTION: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. {ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201}.		negative regulation of signal transduction [GO:0009968]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of signal transduction [GO:0009968]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96D05	reviewed	F241B_HUMAN	Protein FAM241B	FAM241B C10orf35	Homo sapiens (Human)	121	FUNCTION: May play a role in lysosome homeostasis. {ECO:0000269|PubMed:31270356}.			intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]		intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8N8J7}; Single-pass membrane protein {ECO:0000255}.
Q96D09	reviewed	GASP2_HUMAN	G-protein coupled receptor-associated sorting protein 2 (GASP-2)	GPRASP2	Homo sapiens (Human)	838	FUNCTION: May play a role in regulation of a variety of G-protein coupled receptors. {ECO:0000269|PubMed:15086532}.		hematopoietic stem cell homeostasis [GO:0061484]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	amyloid-beta binding [GO:0001540]; G protein-coupled receptor binding [GO:0001664]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; amyloid-beta binding [GO:0001540]; G protein-coupled receptor binding [GO:0001664]; hematopoietic stem cell homeostasis [GO:0061484]	
Q96D15	reviewed	RCN3_HUMAN	Reticulocalbin-3 (EF-hand calcium-binding protein RLP49)	RCN3 UNQ239/PRO272	Homo sapiens (Human)	328	FUNCTION: Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634). {ECO:0000250|UniProtKB:Q8BH97, ECO:0000269|PubMed:16433634, ECO:0000269|PubMed:28939891}.		collagen biosynthetic process [GO:0032964]; ERAD pathway [GO:0036503]; lung epithelium development [GO:0060428]; phospholipid homeostasis [GO:0055091]; positive regulation of peptidase activity [GO:0010952]; protein secretion [GO:0009306]; protein transport [GO:0015031]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; surfactant homeostasis [GO:0043129]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]	calcium ion binding [GO:0005509]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; calcium ion binding [GO:0005509]; collagen biosynthetic process [GO:0032964]; ERAD pathway [GO:0036503]; lung epithelium development [GO:0060428]; phospholipid homeostasis [GO:0055091]; positive regulation of peptidase activity [GO:0010952]; protein secretion [GO:0009306]; protein transport [GO:0015031]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; surfactant homeostasis [GO:0043129]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:16433634}.
Q96D21	reviewed	RHES_HUMAN	GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2)	RASD2 TEM2	Homo sapiens (Human)	266	FUNCTION: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. {ECO:0000269|PubMed:11976265, ECO:0000269|PubMed:19255495}.	MISCELLANEOUS: Reduces cell survival in striatal cells with Huntington disease by binding to mutant Huntington disease protein (mHTT; poly-Gln region with 82 repeats) and inducing sumoylation of mHTT.	locomotory behavior [GO:0007626]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein sumoylation [GO:0033235]; regulation of cAMP-mediated signaling [GO:0043949]; signal transduction [GO:0007165]; synaptic transmission, dopaminergic [GO:0001963]	plasma membrane [GO:0005886]; synapse [GO:0045202]	G-protein beta-subunit binding [GO:0031681]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; synapse [GO:0045202]; G-protein beta-subunit binding [GO:0031681]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; locomotory behavior [GO:0007626]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein sumoylation [GO:0033235]; regulation of cAMP-mediated signaling [GO:0043949]; signal transduction [GO:0007165]; synaptic transmission, dopaminergic [GO:0001963]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Q96D31	reviewed	CRCM1_HUMAN	Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A)	ORAI1 CRACM1 TMEM142A	Homo sapiens (Human)	301	FUNCTION: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928, PubMed:20354224, PubMed:26956484). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901). Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion. {ECO:0000250|UniProtKB:Q8BWG9, ECO:0000269|PubMed:16582901, ECO:0000269|PubMed:16645049, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:20354224, ECO:0000269|PubMed:20887894, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:26956484, ECO:0000269|PubMed:28219928}.	MISCELLANEOUS: In Greek mythology, the 'Orai' are the keepers of the gates of heaven: Eunomia (order or harmony), Dike (justice) and Eirene (peace). {ECO:0000303|PubMed:16582901}.	adaptive immune response [GO:0002250]; calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; mammary gland epithelium development [GO:0061180]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of insulin secretion [GO:0032024]; regulation of calcium ion transport [GO:0051924]; store-operated calcium entry [GO:0002115]	basolateral plasma membrane [GO:0016323]; calcium channel complex [GO:0034704]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]	calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; store-operated calcium channel activity [GO:0015279]	basolateral plasma membrane [GO:0016323]; calcium channel complex [GO:0034704]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; store-operated calcium channel activity [GO:0015279]; adaptive immune response [GO:0002250]; calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; mammary gland epithelium development [GO:0061180]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of insulin secretion [GO:0032024]; regulation of calcium ion transport [GO:0051924]; store-operated calcium entry [GO:0002115]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16582901, ECO:0000269|PubMed:16645049, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:20887894, ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:26956484, ECO:0000269|PubMed:27185316, ECO:0000269|PubMed:28058752, ECO:0000269|PubMed:28219928}; Multi-pass membrane protein {ECO:0000269|PubMed:16582901, ECO:0000269|PubMed:16645049, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:24351972}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8BWG9}; Multi-pass membrane protein {ECO:0000269|PubMed:19249086}. Note=Isoform beta is more mobile in the plasma membrane (PubMed:23307288). Colocalizes with STIM1 at the cell membrane (PubMed:27185316). {ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:27185316}.
Q96D42	reviewed	HAVR1_HUMAN	Hepatitis A virus cellular receptor 1 (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell immunoglobulin mucin receptor 1) (TIM) (TIM-1) (T-cell membrane protein 1) (CD antigen CD365)	HAVCR1 KIM1 TIM1 TIMD1	Homo sapiens (Human)	364	FUNCTION: Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). Acts as regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair (PubMed:17471468). {ECO:0000250|UniProtKB:Q5QNS5, ECO:0000269|PubMed:17471468, ECO:0000269|PubMed:24703780}.; FUNCTION: (Microbial infection) Acts as a receptor for Hepatitis A virus. {ECO:0000269|PubMed:29437974, ECO:0000269|PubMed:9658108}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP (PubMed:26487564). {ECO:0000269|PubMed:21536871, ECO:0000269|PubMed:26487564}.; FUNCTION: (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921). TIM1 and Dengue virus are co-internalized during virus entry (PubMed:29742433). {ECO:0000269|PubMed:23084921, ECO:0000269|PubMed:29742433}.; FUNCTION: (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. {ECO:0000269|PubMed:32641828}.; FUNCTION: (Microbial infection) Plays a positive role in Chikungunya virus cell entry. {ECO:0000269|PubMed:34359995}.	MISCELLANEOUS: The extracellular part of the protein can be cleaved and detected in urine and is in correlation with the expression in the kidney.	phagocytosis, engulfment [GO:0006911]; positive regulation of mast cell activation [GO:0033005]	cell surface [GO:0009986]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]	phosphatidylserine binding [GO:0001786]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; phosphatidylserine binding [GO:0001786]; virus receptor activity [GO:0001618]; phagocytosis, engulfment [GO:0006911]; positive regulation of mast cell activation [GO:0033005]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29742433}; Single-pass type I membrane protein {ECO:0000305}.
Q96D46	reviewed	NMD3_HUMAN	60S ribosomal export protein NMD3 (hNMD3)	NMD3 CGI-07	Homo sapiens (Human)	503	FUNCTION: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}.		positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of RNA biosynthetic process [GO:1902680]; protein transport [GO:0015031]; ribosomal large subunit export from nucleus [GO:0000055]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein-macromolecule adaptor activity [GO:0030674]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-macromolecule adaptor activity [GO:0030674]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of RNA biosynthetic process [GO:1902680]; protein transport [GO:0015031]; ribosomal large subunit export from nucleus [GO:0000055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}. Nucleus {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}. Note=Shuttles between the nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner. {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}.
Q96D53	reviewed	COQ8B_HUMAN	Atypical kinase COQ8B, mitochondrial (EC 2.7.-.-) (AarF domain-containing protein kinase 4) (Coenzyme Q protein 8B)	COQ8B ADCK4	Homo sapiens (Human)	544	FUNCTION: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420). Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration (PubMed:24270420). {ECO:0000250|UniProtKB:Q8NI60, ECO:0000269|PubMed:24270420}.		cerebellar Purkinje cell layer morphogenesis [GO:0021692]; phosphorylation [GO:0016310]; ubiquinone biosynthetic process [GO:0006744]	cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; kinase activity [GO:0016301]; lipid binding [GO:0008289]	cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; kinase activity [GO:0016301]; lipid binding [GO:0008289]; cerebellar Purkinje cell layer morphogenesis [GO:0021692]; phosphorylation [GO:0016310]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:24270420}; Single-pass membrane protein {ECO:0000269|PubMed:24270420}. Cytoplasm, cytosol {ECO:0000269|PubMed:24270420}. Cell membrane {ECO:0000269|PubMed:24270420}.
Q96D59	reviewed	RN183_HUMAN	E3 ubiquitin-protein ligase RNF183 (EC 2.3.2.27)	RNF183	Homo sapiens (Human)	192	FUNCTION: Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). {ECO:0000269|PubMed:29507230, ECO:0000305|PubMed:26567849}.		apoptotic process [GO:0006915]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to endoplasmic reticulum stress [GO:0034976]	cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; apoptotic process [GO:0006915]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29507230}; Single-pass type IV membrane protein {ECO:0000305|PubMed:29507230}. Endoplasmic reticulum {ECO:0000269|PubMed:26567849}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q8QZS5}. Lysosome membrane {ECO:0000250|UniProtKB:Q8QZS5}.
Q96D71	reviewed	REPS1_HUMAN	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)	REPS1	Homo sapiens (Human)	796	FUNCTION: May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}.		endocytosis [GO:0006897]; endosomal transport [GO:0016197]	clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; SH3 domain binding [GO:0017124]	clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; SH3 domain binding [GO:0017124]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]	SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000269|PubMed:20946875}. Note=Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits.
Q96D96	reviewed	HVCN1_HUMAN	Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Voltage sensor domain-only protein)	HVCN1 VSOP UNQ578/PRO1140	Homo sapiens (Human)	273	FUNCTION: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. {ECO:0000269|PubMed:16554753, ECO:0000269|PubMed:20037153, ECO:0000269|PubMed:22020278}.		cell redox homeostasis [GO:0045454]; cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; positive regulation of superoxide anion generation [GO:0032930]; proton transmembrane transport [GO:1902600]; regulation of intracellular pH [GO:0051453]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to pH [GO:0009268]; response to zinc ion [GO:0010043]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]	identical protein binding [GO:0042802]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated proton channel activity [GO:0030171]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; identical protein binding [GO:0042802]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated proton channel activity [GO:0030171]; cell redox homeostasis [GO:0045454]; cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; positive regulation of superoxide anion generation [GO:0032930]; proton transmembrane transport [GO:1902600]; regulation of intracellular pH [GO:0051453]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to pH [GO:0009268]; response to zinc ion [GO:0010043]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Detected mainly at intracellular membranes upon overexpression in HeLa cells (PubMed:20147290), but not in other cell types.
Q96D98	reviewed	EID2B_HUMAN	EP300-interacting inhibitor of differentiation 2B (EID-2B) (EID-2-like inhibitor of differentiation 3) (EID-3)	EID2B EID3	Homo sapiens (Human)	161	FUNCTION: Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation. {ECO:0000269|PubMed:15970276}.		cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myoblast differentiation [GO:0045662]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myoblast differentiation [GO:0045662]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15970276}.
Q96DA2	reviewed	RB39B_HUMAN	Ras-related protein Rab-39B	RAB39B	Homo sapiens (Human)	213	FUNCTION: Small GTPases Rab involved in autophagy (PubMed:27103069). The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:27103069). May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission (By similarity). {ECO:0000250|UniProtKB:Q8BHC1, ECO:0000269|PubMed:27103069}.		autophagy [GO:0006914]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of autophagy [GO:0010506]; synapse organization [GO:0050808]; vesicle-mediated transport [GO:0016192]	cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]	cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; autophagy [GO:0006914]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of autophagy [GO:0010506]; synapse organization [GO:0050808]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:26399558}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:20159109, ECO:0000269|PubMed:24349490}. Note=Partial colocalization with markers that cycle from the cell surface to the trans-Golgi network. {ECO:0000250|UniProtKB:Q8BHC1}.
Q96DA6	reviewed	TIM14_HUMAN	Mitochondrial import inner membrane translocase subunit TIM14 (DnaJ homolog subfamily C member 19)	DNAJC19 TIM14 TIMM14	Homo sapiens (Human)	116	FUNCTION: Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). {ECO:0000250|UniProtKB:Q07914, ECO:0000250|UniProtKB:Q9CQV7}.		genitalia development [GO:0048806]; intracellular protein transport [GO:0006886]; protein folding [GO:0006457]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]; regulation of cardiolipin metabolic process [GO:1900208]; visual perception [GO:0007601]	inner mitochondrial membrane protein complex [GO:0098800]; matrix side of mitochondrial inner membrane [GO:0099617]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; PAM complex, Tim23 associated import motor [GO:0001405]; protein-containing complex [GO:0032991]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	ATPase activator activity [GO:0001671]	inner mitochondrial membrane protein complex [GO:0098800]; matrix side of mitochondrial inner membrane [GO:0099617]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; PAM complex, Tim23 associated import motor [GO:0001405]; protein-containing complex [GO:0032991]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; ATPase activator activity [GO:0001671]; genitalia development [GO:0048806]; intracellular protein transport [GO:0006886]; protein folding [GO:0006457]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]; regulation of cardiolipin metabolic process [GO:1900208]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12592411}; Single-pass membrane protein {ECO:0000305|PubMed:12592411}; Matrix side {ECO:0000250|UniProtKB:Q9CQV7}.
Q96DB2	reviewed	HDA11_HUMAN	Histone deacetylase 11 (HD11) (EC 3.5.1.98)	HDAC11	Homo sapiens (Human)	347	FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. {ECO:0000269|PubMed:11948178}.	MISCELLANEOUS: Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.	chromatin organization [GO:0006325]; oligodendrocyte development [GO:0014003]	histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]	histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; chromatin organization [GO:0006325]; oligodendrocyte development [GO:0014003]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11948178}.
Q96DB5	reviewed	RMD1_HUMAN	Regulator of microtubule dynamics protein 1 (RMD-1) (hRMD-1) (Protein FAM82B)	RMDN1 FAM82B CGI-90	Homo sapiens (Human)	314			attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; mitotic spindle organization [GO:0007052]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; spindle microtubule [GO:0005876]	microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; spindle microtubule [GO:0005876]; microtubule binding [GO:0008017]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; mitotic spindle organization [GO:0007052]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18070910}. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.
Q96DB9	reviewed	FXYD5_HUMAN	FXYD domain-containing ion transport regulator 5 (Dysadherin)	FXYD5 DYSAD IWU1 HSPC113 UNQ2561/PRO6241	Homo sapiens (Human)	178	FUNCTION: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. {ECO:0000269|PubMed:11756660}.		microvillus assembly [GO:0030033]; monoatomic ion transport [GO:0006811]; negative regulation of calcium-dependent cell-cell adhesion [GO:0046588]; regulation of monoatomic ion transport [GO:0043269]	membrane [GO:0016020]	actin binding [GO:0003779]; cadherin binding [GO:0045296]; sodium channel regulator activity [GO:0017080]	membrane [GO:0016020]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; sodium channel regulator activity [GO:0017080]; microvillus assembly [GO:0030033]; monoatomic ion transport [GO:0006811]; negative regulation of calcium-dependent cell-cell adhesion [GO:0046588]; regulation of monoatomic ion transport [GO:0043269]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q96DC9	reviewed	OTUB2_HUMAN	Ubiquitin thioesterase OTUB2 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB2) (OTU domain-containing ubiquitin aldehyde-binding protein 2) (Otubain-2) (Ubiquitin-specific-processing protease OTUB2)	OTUB2 C14orf137 OTB2 OTU2	Homo sapiens (Human)	234	FUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12704427, ECO:0000269|PubMed:18954305, ECO:0000269|PubMed:23827681}.	MISCELLANEOUS: In the structure described by PubMed:15258613, the Asp-48 active site of the catalytic triad is located too far to interact directly with the active site His-224. A possible explanation is that OTUB2 is in inactive conformation in absence of ubiquitin and a conformation change may move Asp-48 in the proximity of His-224 in presence of ubiquitin substrate. {ECO:0000305|PubMed:15258613}.	negative regulation of double-strand break repair [GO:2000780]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]	nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; ubiquitin binding [GO:0043130]	nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; ubiquitin binding [GO:0043130]; negative regulation of double-strand break repair [GO:2000780]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]	
Q96DE0	reviewed	NUD16_HUMAN	U8 snoRNA-decapping enzyme (EC 3.6.1.62) (IDP phosphatase) (IDPase) (EC 3.6.1.64) (Inosine diphosphate phosphatase) (Nucleoside diphosphate-linked moiety X motif 16) (Nudix motif 16) (Nudix hydrolase 16) (U8 snoRNA-binding protein H29K) (m7GpppN-mRNA hydrolase)	NUDT16	Homo sapiens (Human)	195	FUNCTION: RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms (PubMed:20385596, PubMed:26121039). The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP (PubMed:20385596). Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (PubMed:20385596). Exhibits decapping activity towards NAD-capped RNAs and FAD-capped RNAs (PubMed:32432673). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). {ECO:0000250|UniProtKB:Q6P3D0, ECO:0000269|PubMed:15053875, ECO:0000269|PubMed:17567574, ECO:0000269|PubMed:18820299, ECO:0000269|PubMed:20385596, ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:21337011, ECO:0000269|PubMed:26121039, ECO:0000269|PubMed:32432673}.		dITP catabolic process [GO:0035863]; mRNA catabolic process [GO:0006402]; NAD-cap decapping [GO:0110155]; negative regulation of rRNA processing [GO:2000233]; positive regulation of cell cycle process [GO:0090068]; sno(s)RNA catabolic process [GO:0016077]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; chloride ion binding [GO:0031404]; cobalt ion binding [GO:0050897]; dIDP phosphatase activity [GO:0097383]; dITP diphosphatase activity [GO:0035870]; identical protein binding [GO:0042802]; IDP phosphatase activity [GO:1990003]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metalloexopeptidase activity [GO:0008235]; mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; phosphodiesterase decapping endonuclease activity [GO:1990174]; protein homodimerization activity [GO:0042803]; RNA NAD-cap (NMN-forming) hydrolase activity [GO:0110153]; snoRNA binding [GO:0030515]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; chloride ion binding [GO:0031404]; cobalt ion binding [GO:0050897]; dIDP phosphatase activity [GO:0097383]; dITP diphosphatase activity [GO:0035870]; identical protein binding [GO:0042802]; IDP phosphatase activity [GO:1990003]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metalloexopeptidase activity [GO:0008235]; mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; phosphodiesterase decapping endonuclease activity [GO:1990174]; protein homodimerization activity [GO:0042803]; RNA NAD-cap (NMN-forming) hydrolase activity [GO:0110153]; snoRNA binding [GO:0030515]; dITP catabolic process [GO:0035863]; mRNA catabolic process [GO:0006402]; NAD-cap decapping [GO:0110155]; negative regulation of rRNA processing [GO:2000233]; positive regulation of cell cycle process [GO:0090068]; sno(s)RNA catabolic process [GO:0016077]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20385596, ECO:0000269|PubMed:21337011}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q6TEC1}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q6TEC1}. Cytoplasm {ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:21337011}. Note=Localized predominantly in the cytoplasm (PubMed:21070968). Localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm (By similarity). {ECO:0000250|UniProtKB:Q6TEC1, ECO:0000269|PubMed:21070968}.
Q96DE5	reviewed	APC16_HUMAN	Anaphase-promoting complex subunit 16 (APC16) (Cyclosome subunit 16)	ANAPC16 C10orf104 CENP-27	Homo sapiens (Human)	110	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:20360068}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]		anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20360068}. Nucleus {ECO:0000269|PubMed:20360068}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
Q96DF8	reviewed	ESS2_HUMAN	Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2)	ESS2 DGCR13 DGCR14 DGSH DGSI ES2	Homo sapiens (Human)	476	FUNCTION: May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}.		mRNA splicing, via spliceosome [GO:0000398]; nervous system development [GO:0007399]	catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]		catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]; mRNA splicing, via spliceosome [GO:0000398]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P34420}.
Q96DG6	reviewed	CMBL_HUMAN	Carboxymethylenebutenolidase homolog (EC 3.1.-.-)	CMBL	Homo sapiens (Human)	245	FUNCTION: Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}.		xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	hydrolase activity [GO:0016787]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; hydrolase activity [GO:0016787]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20177059}.
Q96DH6	reviewed	MSI2H_HUMAN	RNA-binding protein Musashi homolog 2 (Musashi-2)	MSI2	Homo sapiens (Human)	328	FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}.		central nervous system development [GO:0007417]; regulation of translation [GO:0006417]; stem cell development [GO:0048864]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; polysome [GO:0005844]	identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; polysome [GO:0005844]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; central nervous system development [GO:0007417]; regulation of translation [GO:0006417]; stem cell development [GO:0048864]	SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with polysomes. {ECO:0000250}.
Q96DI7	reviewed	SNR40_HUMAN	U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57)	SNRNP40 PRP8BP SFP38 WDR57	Homo sapiens (Human)	357	FUNCTION: Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30705154). Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome (PubMed:9774689, PubMed:16723661, PubMed:26912367). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9774689, ECO:0000305|PubMed:33509932}.		mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; U2-type catalytic step 2 spliceosome [GO:0071007]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; U2-type catalytic step 2 spliceosome [GO:0071007]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9731529}.
Q96DM3	reviewed	RMC1_HUMAN	Regulator of MON1-CCZ1 complex (Colon cancer-associated protein Mic1) (Mic-1) (WD repeat-containing protein 98)	RMC1 C18orf8 MIC1 WDR98	Homo sapiens (Human)	657	FUNCTION: Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162). {ECO:0000269|PubMed:29038162}.		autophagy [GO:0006914]; regulation of autophagy [GO:0010506]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658]		late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658]; autophagy [GO:0006914]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319}. Late endosome membrane {ECO:0000269|PubMed:29038162}.
Q96DN0	reviewed	ERP27_HUMAN	Endoplasmic reticulum resident protein 27 (ER protein 27) (ERp27) (Inactive protein disulfide-isomerase 27)	ERP27 C12orf46 UNQ781/PRO1575	Homo sapiens (Human)	273	FUNCTION: Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates (PubMed:16940051, PubMed:23192347). Binds protein substrates via a hydrophobic pocket in the C-terminal domain (PubMed:16940051, PubMed:23192347). May play a role in the unfolded stress response (PubMed:23192347). {ECO:0000269|PubMed:16940051, ECO:0000269|PubMed:23192347}.		protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:16940051}.
Q96DN2	reviewed	VWCE_HUMAN	von Willebrand factor C and EGF domain-containing protein (HBV X protein up-regulated gene 11 protein) (HBxAg up-regulated gene 11 protein)	VWCE URG11	Homo sapiens (Human)	955	FUNCTION: May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma. {ECO:0000269|PubMed:16496348}.		cellular response to virus [GO:0098586]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; cellular response to virus [GO:0098586]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Note=According to PubMed:16496348 is localized in the cytoplasm. {ECO:0000269|PubMed:16496348}.
Q96DN5	reviewed	TBC31_HUMAN	TBC1 domain family member 31 (WD repeat-containing protein 67)	TBC1D31 WDR67	Homo sapiens (Human)	1066	FUNCTION: Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation. {ECO:0000269|PubMed:33934390}.		cilium assembly [GO:0060271]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]	molecular adaptor activity [GO:0060090]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; molecular adaptor activity [GO:0060090]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:33934390}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26638075}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:33934390}.
Q96DP5	reviewed	FMT_HUMAN	Methionyl-tRNA formyltransferase, mitochondrial (MtFMT) (EC 2.1.2.9)	MTFMT FMT FMT1	Homo sapiens (Human)	389	FUNCTION: Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation. {ECO:0000269|PubMed:21907147, ECO:0000269|PubMed:25288793}.		conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [GO:0071951]	mitochondrion [GO:0005739]	methionyl-tRNA formyltransferase activity [GO:0004479]	mitochondrion [GO:0005739]; methionyl-tRNA formyltransferase activity [GO:0004479]; conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [GO:0071951]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O77480}.
Q96DR4	reviewed	STAR4_HUMAN	StAR-related lipid transfer protein 4 (START domain-containing protein 4) (StARD4)	STARD4	Homo sapiens (Human)	205	FUNCTION: Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols. {ECO:0000269|PubMed:18403318}.		cholesterol import [GO:0070508]; cholesterol transport involved in cholesterol storage [GO:0010879]; intracellular cholesterol transport [GO:0032367]; positive regulation of bile acid biosynthetic process [GO:0070859]; positive regulation of cholesterol metabolic process [GO:0090205]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; cholesterol import [GO:0070508]; cholesterol transport involved in cholesterol storage [GO:0010879]; intracellular cholesterol transport [GO:0032367]; positive regulation of bile acid biosynthetic process [GO:0070859]; positive regulation of cholesterol metabolic process [GO:0090205]	
Q96DR5	reviewed	BPIA2_HUMAN	BPI fold-containing family A member 2 (Parotid secretory protein) (PSP) (Short palate, lung and nasal epithelium carcinoma-associated protein 2)	BPIFA2 C20orf70 SPLUNC2 UNQ510/PRO1025	Homo sapiens (Human)	249	FUNCTION: Has strong antibacterial activity against P. aeruginosa. {ECO:0000269|PubMed:24581853}.		defense response to bacterium [GO:0042742]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]	lipopolysaccharide binding [GO:0001530]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; lipopolysaccharide binding [GO:0001530]; defense response to bacterium [GO:0042742]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q96DR7	reviewed	ARHGQ_HUMAN	Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)	ARHGEF26 SGEF HMFN1864	Homo sapiens (Human)	871	FUNCTION: Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}.		endothelial cell morphogenesis [GO:0001886]; ruffle assembly [GO:0097178]	cytosol [GO:0005829]; ruffle [GO:0001726]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; ruffle [GO:0001726]; guanyl-nucleotide exchange factor activity [GO:0005085]; endothelial cell morphogenesis [GO:0001886]; ruffle assembly [GO:0097178]	SUBCELLULAR LOCATION: Cell projection, ruffle {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17875742}.
Q96DR8	reviewed	MUCL1_HUMAN	Mucin-like protein 1 (Protein BS106) (Small breast epithelial mucin)	MUCL1 SBEM UNQ590/PRO1160	Homo sapiens (Human)	90	FUNCTION: May play a role as marker for the diagnosis of metastatic breast cancer. {ECO:0000269|PubMed:12019145, ECO:0000269|PubMed:12595743, ECO:0000269|PubMed:15684711}.			extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:15880534}. Membrane {ECO:0000305|PubMed:15880534}.
Q96DT5	reviewed	DYH11_HUMAN	Dynein axonemal heavy chain 11 (Axonemal beta dynein heavy chain 11) (Ciliary dynein heavy chain 11)	DNAH11	Homo sapiens (Human)	4516	FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.		cardiac septum morphogenesis [GO:0060411]; cilium movement involved in cell motility [GO:0060294]; determination of left/right asymmetry in nervous system [GO:0035545]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; flagellated sperm motility [GO:0030317]; learning or memory [GO:0007611]; protein localization to motile cilium [GO:0120229]; regulation of cilium beat frequency [GO:0003356]	9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; proximal portion of axoneme [GO:0120134]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]	9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; proximal portion of axoneme [GO:0120134]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; cardiac septum morphogenesis [GO:0060411]; cilium movement involved in cell motility [GO:0060294]; determination of left/right asymmetry in nervous system [GO:0035545]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; flagellated sperm motility [GO:0030317]; learning or memory [GO:0007611]; protein localization to motile cilium [GO:0120229]; regulation of cilium beat frequency [GO:0003356]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:31178125, ECO:0000269|PubMed:33139725}. Note=Located in the proximal region of respiratory cilia. {ECO:0000269|PubMed:33139725}.
Q96DT6	reviewed	ATG4C_HUMAN	Cysteine protease ATG4C (EC 3.4.22.-) (AUT-like 3 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 3) (Autophagin-3) (Autophagy-related protein 4 homolog C) (HsAPG4C)	ATG4C APG4C AUTL1 AUTL3	Homo sapiens (Human)	458	FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:21177865, PubMed:29458288, PubMed:30661429). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (PubMed:21177865). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:29458288, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:29458288, PubMed:33909989). Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity (PubMed:29458288). In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy (PubMed:33773106). {ECO:0000250|UniProtKB:Q9Y4P1, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; protein delipidation [GO:0051697]; protein transport [GO:0015031]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]	cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786]	cytoplasm [GO:0005737]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; protein delipidation [GO:0051697]; protein transport [GO:0015031]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BGE6}.
Q96DT7	reviewed	ZBT10_HUMAN	Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF)	ZBTB10 RINZF RINZFC	Homo sapiens (Human)	871	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromosome, telomeric region [GO:0000781]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; telomeric DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; telomeric DNA binding [GO:0042162]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96DU3	reviewed	SLAF6_HUMAN	SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352)	SLAMF6 KALI UNQ6123/PRO20080	Homo sapiens (Human)	332	FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity). {ECO:0000250|UniProtKB:Q9ET39, ECO:0000269|PubMed:11489943, ECO:0000269|PubMed:16920955, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}.		innate immune response [GO:0045087]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of type II interferon production [GO:0032729]; T cell activation [GO:0042110]; T-helper 17 cell lineage commitment [GO:0072540]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]		external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; innate immune response [GO:0045087]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of type II interferon production [GO:0032729]; T cell activation [GO:0042110]; T-helper 17 cell lineage commitment [GO:0072540]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q96DU7	reviewed	IP3KC_HUMAN	Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase C) (IP3 3-kinase C) (IP3K C) (InsP 3-kinase C)	ITPKC IP3KC	Homo sapiens (Human)	683	FUNCTION: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:11085927, PubMed:12747803). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity). {ECO:0000250|UniProtKB:Q80ZG2, ECO:0000269|PubMed:11085927, ECO:0000269|PubMed:12747803}.		cellular response to calcium ion [GO:0071277]; inositol phosphate biosynthetic process [GO:0032958]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]; cellular response to calcium ion [GO:0071277]; inositol phosphate biosynthetic process [GO:0032958]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12747803}. Cytoplasm {ECO:0000269|PubMed:12747803}. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. {ECO:0000250|UniProtKB:Q80ZG2}.
Q96DV4	reviewed	RM38_HUMAN	Large ribosomal subunit protein mL38 (39S ribosomal protein L38, mitochondrial) (L38mt) (MRP-L38)	MRPL38 HSPC262	Homo sapiens (Human)	380			mitochondrial translation [GO:0032543]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q96DW6	reviewed	S2538_HUMAN	Mitochondrial glycine transporter (Appoptosin) (Mitochondrial glycine transporter GlyC) (Solute carrier family 25 member 38)	SLC25A38	Homo sapiens (Human)	304	FUNCTION: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. {ECO:0000255|HAMAP-Rule:MF_03064, ECO:0000269|PubMed:19412178, ECO:0000269|PubMed:27476175}.; FUNCTION: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis. {ECO:0000250|UniProtKB:Q91XD8}.		erythrocyte differentiation [GO:0030218]; glycine import into mitochondrion [GO:1904983]; heme biosynthetic process [GO:0006783]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	glycine transmembrane transporter activity [GO:0015187]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; glycine transmembrane transporter activity [GO:0015187]; erythrocyte differentiation [GO:0030218]; glycine import into mitochondrion [GO:1904983]; heme biosynthetic process [GO:0006783]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03064}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03064}.
Q96DX5	reviewed	ASB9_HUMAN	Ankyrin repeat and SOCS box protein 9 (ASB-9)	ASB9	Homo sapiens (Human)	294	FUNCTION: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A. {ECO:0000269|PubMed:22418839}.	MISCELLANEOUS: [Isoform 2]: Does not interact with the Elongin BC complex, likely to be a negative regulator of isoform 1. {ECO:0000305}.	intracellular signal transduction [GO:0035556]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; mitochondrion [GO:0005739]; intracellular signal transduction [GO:0035556]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20302626}.
Q96DX7	reviewed	TRI44_HUMAN	Tripartite motif-containing protein 44 (Protein DIPB)	TRIM44 DIPB	Homo sapiens (Human)	344	FUNCTION: May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807). {ECO:0000250, ECO:0000269|PubMed:19358823, ECO:0000269|PubMed:26394807}.		negative regulation of protein K48-linked ubiquitination [GO:0061944]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; negative regulation of protein K48-linked ubiquitination [GO:0061944]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
Q96DX8	reviewed	RTP4_HUMAN	Receptor-transporting protein 4 (28 kDa interferon-responsive protein) (3CxxC-type zinc finger protein 4)	RTP4 IFRG28 Z3CXXC4	Homo sapiens (Human)	246	FUNCTION: Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). {ECO:0000250|UniProtKB:Q9ER80, ECO:0000269|PubMed:16720576}.		defense response to virus [GO:0051607]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612]	cytoplasm [GO:0005737]; membrane [GO:0016020]	metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849]	cytoplasm [GO:0005737]; membrane [GO:0016020]; metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849]; defense response to virus [GO:0051607]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Q96DZ1	reviewed	ERLEC_HUMAN	Endoplasmic reticulum lectin 1 (ER lectin) (Erlectin) (XTP3-transactivated gene B protein)	ERLEC1 C2orf30 XTP3TPB UNQ1878/PRO4321	Homo sapiens (Human)	483	FUNCTION: Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins. {ECO:0000269|PubMed:16531414, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18502753}.		endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]	unfolded protein binding [GO:0051082]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; unfolded protein binding [GO:0051082]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:16531414, ECO:0000269|PubMed:18502753}.
Q96DZ5	reviewed	CLIP3_HUMAN	CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59)	CLIP3 CLIPR59	Homo sapiens (Human)	547	FUNCTION: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes. {ECO:0000269|PubMed:19139280}.	MISCELLANEOUS: The N-terminal half is dispensable for proper Golgi targeting, whereas the GoLD region is required.	cytoplasmic microtubule organization [GO:0031122]; fat cell differentiation [GO:0045444]; membrane biogenesis [GO:0044091]; negative regulation of microtubule polymerization [GO:0031115]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endocytosis [GO:0045807]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; protein transport along microtubule [GO:0098840]	cell cortex [GO:0005938]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; Golgi stack [GO:0005795]; membrane raft [GO:0045121]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	ganglioside binding [GO:0035594]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]	cell cortex [GO:0005938]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; Golgi stack [GO:0005795]; membrane raft [GO:0045121]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; ganglioside binding [GO:0035594]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; cytoplasmic microtubule organization [GO:0031122]; fat cell differentiation [GO:0045444]; membrane biogenesis [GO:0044091]; negative regulation of microtubule polymerization [GO:0031115]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endocytosis [GO:0045807]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; protein transport along microtubule [GO:0098840]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24001771}; Lipid-anchor {ECO:0000269|PubMed:24001771}. Cytoplasm {ECO:0000269|PubMed:24001771}. Golgi apparatus, Golgi stack {ECO:0000269|PubMed:24001771}. Note=Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.
Q96DZ7	reviewed	T4S19_HUMAN	Transmembrane 4 L6 family member 19 (Osteoclast maturation-associated gene 4 protein) (Tetraspan membrane protein OCTM4)	TM4SF19 OCTM4	Homo sapiens (Human)	209				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96DZ9	reviewed	CKLF5_HUMAN	CKLF-like MARVEL transmembrane domain-containing protein 5 (Chemokine-like factor superfamily member 5)	CMTM5 CKLFSF5	Homo sapiens (Human)	223			chemotaxis [GO:0006935]; negative regulation of myoblast differentiation [GO:0045662]	extracellular space [GO:0005615]; membrane [GO:0016020]	cytokine activity [GO:0005125]	extracellular space [GO:0005615]; membrane [GO:0016020]; cytokine activity [GO:0005125]; chemotaxis [GO:0006935]; negative regulation of myoblast differentiation [GO:0045662]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q96E09	reviewed	PBIR1_HUMAN	PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1)	PABIR1 C9orf42 FAM122A	Homo sapiens (Human)	287	FUNCTION: Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758}.		mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of cell growth [GO:0030307]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein serine/threonine phosphatase inhibitor activity [GO:0004865]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of cell growth [GO:0030307]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33108758}. Cytoplasm {ECO:0000269|PubMed:33108758}. Note=The CHEK1-mediated Ser-37 phosphorylated form is sequestered by 14-3-3 proteins in the cytoplasm and fails to translocate to the nucleus, where it otherwise inhibits serine/threonine-protein phosphatase 2A. {ECO:0000269|PubMed:33108758}.
Q96E11	reviewed	RRFM_HUMAN	Ribosome-recycling factor, mitochondrial (RRF) (mtRRF) (Ribosome-releasing factor, mitochondrial)	MRRF	Homo sapiens (Human)	262	FUNCTION: Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with GFM2 (PubMed:33878294). Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts (PubMed:33878294). {ECO:0000269|PubMed:19716793, ECO:0000269|PubMed:33878294}.		ribosome disassembly [GO:0032790]; translation [GO:0006412]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ribosomal large subunit binding [GO:0043023]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribosomal large subunit binding [GO:0043023]; ribosome disassembly [GO:0032790]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18782833}.
Q96E14	reviewed	RMI2_HUMAN	RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18)	RMI2 C16orf75	Homo sapiens (Human)	147	FUNCTION: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. {ECO:0000269|PubMed:18923082, ECO:0000269|PubMed:18923083, ECO:0000269|PubMed:27977684}.		DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; maintenance of rDNA [GO:0043007]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of sister chromatid segregation [GO:0033045]; resolution of recombination intermediates [GO:0071139]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RecQ family helicase-topoisomerase III complex [GO:0031422]	DNA binding [GO:0003677]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RecQ family helicase-topoisomerase III complex [GO:0031422]; DNA binding [GO:0003677]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; maintenance of rDNA [GO:0043007]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of sister chromatid segregation [GO:0033045]; resolution of recombination intermediates [GO:0071139]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18923082}. Note=Colocalizes with BLM at nuclear DNA repair foci.
Q96E17	reviewed	RAB3C_HUMAN	Ras-related protein Rab-3C	RAB3C	Homo sapiens (Human)	227	FUNCTION: Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250}.		antigen processing and presentation [GO:0019882]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904]	endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982]	GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]	endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; antigen processing and presentation [GO:0019882]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q96E22	reviewed	NGBR_HUMAN	Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Cis-prenyltransferase subunit NgBR) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog)	NUS1 C6orf68 NGBR	Homo sapiens (Human)	293	FUNCTION: With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300). {ECO:0000269|PubMed:16835300, ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056, ECO:0000269|PubMed:28842490, ECO:0000269|PubMed:32817466}.	MISCELLANEOUS: NUS1 seems to exist in two topological orientations, a minor glycosylated species with its C-terminus oriented towards the lumen regulating NPC2 stability, and a major fraction oriented with its C-terminus directed towards the cytosol where it regulates cis-IPTase activity. {ECO:0000303|PubMed:21572394}.	angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; dolichol biosynthetic process [GO:0019408]; dolichyl diphosphate biosynthetic process [GO:0006489]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of nitric-oxide synthase activity [GO:0051000]; protein glycosylation [GO:0006486]; regulation of intracellular cholesterol transport [GO:0032383]; vascular endothelial growth factor signaling pathway [GO:0038084]	dehydrodolichyl diphosphate synthase complex [GO:1904423]; endoplasmic reticulum membrane [GO:0005789]	dehydrodolichyl diphosphate synthase activity [GO:0045547]; metal ion binding [GO:0046872]	dehydrodolichyl diphosphate synthase complex [GO:1904423]; endoplasmic reticulum membrane [GO:0005789]; dehydrodolichyl diphosphate synthase activity [GO:0045547]; metal ion binding [GO:0046872]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; dolichol biosynthetic process [GO:0019408]; dolichyl diphosphate biosynthetic process [GO:0006489]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of nitric-oxide synthase activity [GO:0051000]; protein glycosylation [GO:0006486]; regulation of intracellular cholesterol transport [GO:0032383]; vascular endothelial growth factor signaling pathway [GO:0038084]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19723497, ECO:0000269|PubMed:21572394}; Multi-pass membrane protein {ECO:0000303|PubMed:21572394}. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. {ECO:0000269|PubMed:19723497}.
Q96E29	reviewed	MTEF3_HUMAN	Transcription termination factor 3, mitochondrial (Mitochondrial transcription termination factor 3) (mTERF3) (mTERF domain-containing protein 1, mitochondrial)	MTERF3 MTERFD1 CGI-12	Homo sapiens (Human)	417	FUNCTION: Binds promoter DNA and regulates initiation of transcription (PubMed:17662942). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity). {ECO:0000250|UniProtKB:Q8R3J4, ECO:0000269|PubMed:17662942}.		mitochondrial ribosome assembly [GO:0061668]; mitochondrial transcription [GO:0006390]; negative regulation of DNA-templated transcription [GO:0045892]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	transcription cis-regulatory region binding [GO:0000976]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; transcription cis-regulatory region binding [GO:0000976]; mitochondrial ribosome assembly [GO:0061668]; mitochondrial transcription [GO:0006390]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:17662942, ECO:0000269|PubMed:23300484}.
Q96E35	reviewed	ZMY19_HUMAN	Zinc finger MYND domain-containing protein 19 (Melanin-concentrating hormone receptor 1-interacting zinc finger protein) (MCH-R1-interacting zinc finger protein)	ZMYND19 MIZIP	Homo sapiens (Human)	227	FUNCTION: May be involved as a regulatory molecule in GPR24/MCH-R1 signaling.			cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12208518}. Cell membrane {ECO:0000269|PubMed:12208518}; Peripheral membrane protein {ECO:0000269|PubMed:12208518}.
Q96E40	reviewed	SACA9_HUMAN	Sperm acrosome-associated protein 9	SPACA9 C9orf9	Homo sapiens (Human)	222	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated spermatozoa. Forms both spirals and striations within ciliary microtubules. May stabilize the protofilaments to which they are bound. {ECO:0000269|PubMed:36191189}.		axoneme assembly [GO:0035082]	acrosomal vesicle [GO:0001669]; axonemal microtubule [GO:0005879]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasmic microtubule [GO:0005881]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	calcium-dependent protein binding [GO:0048306]; microtubule binding [GO:0008017]	acrosomal vesicle [GO:0001669]; axonemal microtubule [GO:0005879]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasmic microtubule [GO:0005881]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; calcium-dependent protein binding [GO:0048306]; microtubule binding [GO:0008017]; axoneme assembly [GO:0035082]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7TPM5}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q7TPM5}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q7TPM5}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q7TPM5}. Nucleus {ECO:0000250|UniProtKB:Q4V8P4}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Note=In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome. {ECO:0000250|UniProtKB:Q7TPM5}.
Q96E52	reviewed	OMA1_HUMAN	Metalloendopeptidase OMA1, mitochondrial (EC 3.4.24.-) (Metalloprotease-related protein 1) (MPRP-1) (Overlapping with the m-AAA protease 1 homolog)	OMA1 MPRP1	Homo sapiens (Human)	524	FUNCTION: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria (PubMed:20038677, PubMed:25605331, PubMed:32132706, PubMed:32132707). Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1 (PubMed:20038677, PubMed:25275009, PubMed:32132706, PubMed:32132707). Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion (PubMed:20038677, PubMed:25275009). Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae (PubMed:25275009). In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome (PubMed:30733118). May also cleave UQCC3 in response to mitochondrial depolarization (PubMed:25605331). Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (PubMed:32132706, PubMed:32132707). Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity). Binds cardiolipin, possibly regulating its protein turnover (By similarity). Required for the stability of the respiratory supercomplexes (By similarity). {ECO:0000250|UniProtKB:Q9D8H7, ECO:0000269|PubMed:20038677, ECO:0000269|PubMed:25275009, ECO:0000269|PubMed:25605331, ECO:0000269|PubMed:30733118, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707}.		cristae formation [GO:0042407]; diet induced thermogenesis [GO:0002024]; energy homeostasis [GO:0097009]; glucose metabolic process [GO:0006006]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; lipid metabolic process [GO:0006629]; mitochondrial protein processing [GO:0034982]; mitochondrial respiratory chain complex assembly [GO:0033108]; negative regulation of mitochondrial fusion [GO:0010637]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cold-induced thermogenesis [GO:0120162]; protein autoprocessing [GO:0016540]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of apoptotic process [GO:0042981]; regulation of cristae formation [GO:1903850]; zymogen activation [GO:0031638]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]	lipid binding [GO:0008289]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; cristae formation [GO:0042407]; diet induced thermogenesis [GO:0002024]; energy homeostasis [GO:0097009]; glucose metabolic process [GO:0006006]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; lipid metabolic process [GO:0006629]; mitochondrial protein processing [GO:0034982]; mitochondrial respiratory chain complex assembly [GO:0033108]; negative regulation of mitochondrial fusion [GO:0010637]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cold-induced thermogenesis [GO:0120162]; protein autoprocessing [GO:0016540]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of apoptotic process [GO:0042981]; regulation of cristae formation [GO:1903850]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:32132707, ECO:0000305|PubMed:20038677}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9D8H7}.
Q96E93	reviewed	KLRG1_HUMAN	Killer cell lectin-like receptor subfamily G member 1 (C-type lectin domain family 15 member A) (ITIM-containing receptor MAFA-L) (MAFA-like receptor) (Mast cell function-associated antigen)	KLRG1 CLEC15A MAFA MAFAL	Homo sapiens (Human)	195	FUNCTION: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. {ECO:0000269|PubMed:19604491}.		cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19604491}; Single-pass type II membrane protein {ECO:0000269|PubMed:19604491}.
Q96EA4	reviewed	SPDLY_HUMAN	Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1)	SPDL1 CCDC99	Homo sapiens (Human)	605	FUNCTION: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Plays a role in cell migration (PubMed:30258100). {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:30258100}.		cell division [GO:0051301]; cell migration [GO:0016477]; establishment of mitotic spindle orientation [GO:0000132]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922]	enzyme binding [GO:0019899]; kinetochore binding [GO:0043515]	cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922]; enzyme binding [GO:0019899]; kinetochore binding [GO:0043515]; cell division [GO:0051301]; cell migration [GO:0016477]; establishment of mitotic spindle orientation [GO:0000132]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.
Q96EB1	reviewed	ELP4_HUMAN	Elongator complex protein 4 (hELP4) (PAX6 neighbor gene protein)	ELP4 C11orf19 PAXNEB	Homo sapiens (Human)	424	FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). {ECO:0000303|PubMed:29332244}.		regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; transcription elongation by RNA polymerase II [GO:0006368]; tRNA wobble uridine modification [GO:0002098]	cytoplasm [GO:0005737]; elongator holoenzyme complex [GO:0033588]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]	phosphorylase kinase regulator activity [GO:0008607]	cytoplasm [GO:0005737]; elongator holoenzyme complex [GO:0033588]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]; phosphorylase kinase regulator activity [GO:0008607]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; transcription elongation by RNA polymerase II [GO:0006368]; tRNA wobble uridine modification [GO:0002098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:11889558, ECO:0000269|PubMed:22854966}. Nucleus {ECO:0000269|PubMed:11889558}.
Q96EB6	reviewed	SIR1_HUMAN	NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]	SIRT1 SIR2L1	Homo sapiens (Human)	747	FUNCTION: NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:24415752, PubMed:24824780, PubMed:29765047, PubMed:30409912, PubMed:29681526). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:15152190, PubMed:14980222, PubMed:14976264). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14980222, PubMed:14976264, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17620057, PubMed:17283066, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:17334224, PubMed:16998810, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). In addition to protein deacetylase activity, also acts as protein-lysine deacylase by mediating protein depropionylation and decrotonylation (PubMed:28497810). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication. Deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}.	MISCELLANEOUS: Red wine, which contains resveratrol, may participate in activation of sirtuin proteins, and may therefore participate in an extended lifespan as it has been observed in yeast.; MISCELLANEOUS: Calf histone H1 is used as substrate in the in vitro deacetylation assay (PubMed:15469825). As, in vivo, interaction occurs between SIRT1 with H1-4, deacetylation has been validated only for H1-4. {ECO:0000305|PubMed:15469825}.; MISCELLANEOUS: The reported ADP-ribosyltransferase activity of sirtuins is likely some inefficient side reaction of the deacetylase activity and may not be physiologically relevant. {ECO:0000305|PubMed:19220062}.	angiogenesis [GO:0001525]; behavioral response to starvation [GO:0042595]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; DNA damage response [GO:0006974]; DNA methylation-dependent heterochromatin formation [GO:0006346]; DNA repair-dependent chromatin remodeling [GO:0140861]; DNA synthesis involved in DNA repair [GO:0000731]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; heterochromatin formation [GO:0031507]; intracellular glucose homeostasis [GO:0001678]; intracellular triglyceride homeostasis [GO:0035356]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; leptin-mediated signaling pathway [GO:0033210]; macrophage differentiation [GO:0030225]; maintenance of nucleus location [GO:0051658]; muscle organ development [GO:0007517]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902424]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell cycle [GO:0045786]; negative regulation of cellular response to testosterone stimulus [GO:2000655]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of helicase activity [GO:0051097]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of phosphorylation [GO:0042326]; negative regulation of prostaglandin biosynthetic process [GO:0031393]; negative regulation of protein acetylation [GO:1901984]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of triglyceride biosynthetic process [GO:0010868]; ovulation from ovarian follicle [GO:0001542]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular senescence [GO:2000774]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of macroautophagy [GO:0016239]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deacetylation [GO:0006476]; protein depropionylation [GO:0106230]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; rDNA heterochromatin formation [GO:0000183]; regulation of apoptotic process [GO:0042981]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of brown fat cell differentiation [GO:0090335]; regulation of cell population proliferation [GO:0042127]; regulation of cellular response to heat [GO:1900034]; regulation of centrosome duplication [GO:0010824]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid storage [GO:0010883]; regulation of mitotic cell cycle [GO:0007346]; regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358]; regulation of protein serine/threonine kinase activity [GO:0071900]; regulation of smooth muscle cell apoptotic process [GO:0034391]; regulation of transcription by glucose [GO:0046015]; response to hydrogen peroxide [GO:0042542]; response to insulin [GO:0032868]; response to leptin [GO:0044321]; response to oxidative stress [GO:0006979]; single strand break repair [GO:0000012]; spermatogenesis [GO:0007283]; stress-induced premature senescence [GO:0090400]; transforming growth factor beta receptor signaling pathway [GO:0007179]; triglyceride mobilization [GO:0006642]; UV-damage excision repair [GO:0070914]; white fat cell differentiation [GO:0050872]	chromatin [GO:0000785]; chromatin silencing complex [GO:0005677]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; eNoSc complex [GO:0061773]; euchromatin [GO:0000791]; fibrillar center [GO:0001650]; heterochromatin [GO:0000792]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; rDNA heterochromatin [GO:0033553]	bHLH transcription factor binding [GO:0043425]; deacetylase activity [GO:0019213]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; histone deacetylase activity [GO:0004407]; histone H3K deacetylase activity [GO:0141050]; histone H4K12 deacetylase activity [GO:0140937]; HLH domain binding [GO:0043398]; identical protein binding [GO:0042802]; keratin filament binding [GO:1990254]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; NAD+ binding [GO:0070403]; NAD-dependent histone deacetylase activity [GO:0017136]; NAD-dependent histone decrotonylase activity [GO:0160012]; NAD-dependent histone H3K14 deacetylase activity [GO:0032041]; NAD-dependent histone H3K9 deacetylase activity [GO:0046969]; NAD-dependent histone H4K16 deacetylase activity [GO:0046970]; NAD-dependent protein deacetylase activity [GO:0034979]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein lysine deacetylase activity [GO:0033558]; protein-propionyllysine depropionylase activity [GO:0106231]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; chromatin silencing complex [GO:0005677]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; eNoSc complex [GO:0061773]; euchromatin [GO:0000791]; fibrillar center [GO:0001650]; heterochromatin [GO:0000792]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; rDNA heterochromatin [GO:0033553]; bHLH transcription factor binding [GO:0043425]; deacetylase activity [GO:0019213]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; histone deacetylase activity [GO:0004407]; histone H3K deacetylase activity [GO:0141050]; histone H4K12 deacetylase activity [GO:0140937]; HLH domain binding [GO:0043398]; identical protein binding [GO:0042802]; keratin filament binding [GO:1990254]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; NAD+ binding [GO:0070403]; NAD-dependent histone deacetylase activity [GO:0017136]; NAD-dependent histone decrotonylase activity [GO:0160012]; NAD-dependent histone H3K14 deacetylase activity [GO:0032041]; NAD-dependent histone H3K9 deacetylase activity [GO:0046969]; NAD-dependent histone H4K16 deacetylase activity [GO:0046970]; NAD-dependent protein deacetylase activity [GO:0034979]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein lysine deacetylase activity [GO:0033558]; protein-propionyllysine depropionylase activity [GO:0106231]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; angiogenesis [GO:0001525]; behavioral response to starvation [GO:0042595]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; DNA damage response [GO:0006974]; DNA methylation-dependent heterochromatin formation [GO:0006346]; DNA repair-dependent chromatin remodeling [GO:0140861]; DNA synthesis involved in DNA repair [GO:0000731]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; heterochromatin formation [GO:0031507]; intracellular glucose homeostasis [GO:0001678]; intracellular triglyceride homeostasis [GO:0035356]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; leptin-mediated signaling pathway [GO:0033210]; macrophage differentiation [GO:0030225]; maintenance of nucleus location [GO:0051658]; muscle organ development [GO:0007517]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902424]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell cycle [GO:0045786]; negative regulation of cellular response to testosterone stimulus [GO:2000655]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of helicase activity [GO:0051097]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of phosphorylation [GO:0042326]; negative regulation of prostaglandin biosynthetic process [GO:0031393]; negative regulation of protein acetylation [GO:1901984]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of triglyceride biosynthetic process [GO:0010868]; ovulation from ovarian follicle [GO:0001542]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular senescence [GO:2000774]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of macroautophagy [GO:0016239]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deacetylation [GO:0006476]; protein depropionylation [GO:0106230]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; rDNA heterochromatin formation [GO:0000183]; regulation of apoptotic process [GO:0042981]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of brown fat cell differentiation [GO:0090335]; regulation of cell population proliferation [GO:0042127]; regulation of cellular response to heat [GO:1900034]; regulation of centrosome duplication [GO:0010824]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid storage [GO:0010883]; regulation of mitotic cell cycle [GO:0007346]; regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358]; regulation of protein serine/threonine kinase activity [GO:0071900]; regulation of smooth muscle cell apoptotic process [GO:0034391]; regulation of transcription by glucose [GO:0046015]; response to hydrogen peroxide [GO:0042542]; response to insulin [GO:0032868]; response to leptin [GO:0044321]; response to oxidative stress [GO:0006979]; single strand break repair [GO:0000012]; spermatogenesis [GO:0007283]; stress-induced premature senescence [GO:0090400]; transforming growth factor beta receptor signaling pathway [GO:0007179]; triglyceride mobilization [GO:0006642]; UV-damage excision repair [GO:0070914]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000269|PubMed:12006491}. Cytoplasm {ECO:0000269|PubMed:20027304}. Nucleus {ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20027304, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:20955178}. Note=Recruited to the nuclear bodies via its interaction with PML (PubMed:12006491). Colocalized with APEX1 in the nucleus (PubMed:19934257). May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane (PubMed:15469825). Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20955178}.; SUBCELLULAR LOCATION: [SirtT1 75 kDa fragment]: Cytoplasm {ECO:0000269|PubMed:21987377}. Mitochondrion {ECO:0000269|PubMed:21987377}.
Q96EC8	reviewed	YIPF6_HUMAN	Protein YIPF6 (YIP1 family member 6)	YIPF6	Homo sapiens (Human)	236	FUNCTION: May be required for stable YIPF1 and YIPF2 protein expression. {ECO:0000269|PubMed:28286305}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intestinal epithelial cell development [GO:0060576]	cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; trans-Golgi network [GO:0005802]	identical protein binding [GO:0042802]	cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; trans-Golgi network [GO:0005802]; identical protein binding [GO:0042802]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intestinal epithelial cell development [GO:0060576]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein {ECO:0000305}. Note=Evenly distributed between cis- and trans-Golgi apparatus (PubMed:27999994). Mainly localizes within medial-/trans-Golgi and trans-Golgi network (TGN), while less so within cis-Golgi (PubMed:28286305). {ECO:0000269|PubMed:27999994, ECO:0000269|PubMed:28286305}.
Q96ED9	reviewed	HOOK2_HUMAN	Protein Hook homolog 2 (h-hook2) (hHK2)	HOOK2	Homo sapiens (Human)	719	FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}.		cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FHF complex [GO:0070695]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; trans-Golgi network [GO:0005802]	dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FHF complex [GO:0070695]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; trans-Golgi network [GO:0005802]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17140400}. Cytoplasm {ECO:0000269|PubMed:32073997}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q7TMK6}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:32073997}. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome (PubMed:17540036). Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosome, or mitochondria (PubMed:17540036, PubMed:32073997). Often found in close association with microtubules (PubMed:17540036). Localizes to the manchette in elongating spermatids (By similarity). {ECO:0000250|UniProtKB:Q7TMK6, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:32073997}.
Q96EE3	reviewed	SEH1_HUMAN	Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein)	SEH1L SEC13L SEH1	Homo sapiens (Human)	360	FUNCTION: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC (PubMed:15146057, PubMed:17363900). The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (PubMed:15146057, PubMed:17363900). {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}.; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:25457612, PubMed:23723238, PubMed:27487210, PubMed:36528027, PubMed:35831510). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:36528027, PubMed:35831510). GATOR2 probably acts as a E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}.		attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; defense response to Gram-positive bacterium [GO:0050830]; mitotic metaphase chromosome alignment [GO:0007080]; mRNA transport [GO:0051028]; negative regulation of TORC1 signaling [GO:1904262]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein transport [GO:0015031]; protein-containing complex localization [GO:0031503]	cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; kinetochore [GO:0000776]; lysosomal membrane [GO:0005765]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; Seh1-associated complex [GO:0035859]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; kinetochore [GO:0000776]; lysosomal membrane [GO:0005765]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; Seh1-associated complex [GO:0035859]; structural molecule activity [GO:0005198]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; defense response to Gram-positive bacterium [GO:0050830]; mitotic metaphase chromosome alignment [GO:0007080]; mRNA transport [GO:0051028]; negative regulation of TORC1 signaling [GO:1904262]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein transport [GO:0015031]; protein-containing complex localization [GO:0031503]	SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}. Lysosome membrane {ECO:0000269|PubMed:28199306}.
Q96EF0	reviewed	MTMR8_HUMAN	Myotubularin-related protein 8 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)	MTMR8	Homo sapiens (Human)	704	FUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:22647598, PubMed:26143924). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:22647598, PubMed:26143924). In complex with MTMR9, negatively regulates autophagy (PubMed:22647598). {ECO:0000269|PubMed:22647598, ECO:0000269|PubMed:26143924}.		negative regulation of autophagy [GO:0010507]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of macroautophagy [GO:0016241]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; protein-containing complex [GO:0032991]	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate phosphatase activity [GO:0106018]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; protein-containing complex [GO:0032991]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate phosphatase activity [GO:0106018]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; negative regulation of autophagy [GO:0010507]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of macroautophagy [GO:0016241]	SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:16787938}.
Q96EF6	reviewed	FBX17_HUMAN	F-box only protein 17 (F-box only protein 26)	FBXO17 FBG4 FBX17 FBX26 FBXO26	Homo sapiens (Human)	278	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.		glycoprotein catabolic process [GO:0006516]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; glycoprotein catabolic process [GO:0006516]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]	
Q96EG1	reviewed	ARSG_HUMAN	Arylsulfatase G (ASG) (EC 3.1.6.1) (N-sulfoglucosamine-3-sulfatase) (EC 3.1.6.15)	ARSG KIAA1001 UNQ839/PRO1777	Homo sapiens (Human)	525	FUNCTION: Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate (PubMed:18283100, PubMed:29300381). Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin (PubMed:22689975). {ECO:0000269|PubMed:18283100, ECO:0000269|PubMed:22689975, ECO:0000269|PubMed:29300381}.		sulfur compound metabolic process [GO:0006790]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; lysosome [GO:0005764]	arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-sulfoglucosamine-3-sulfatase activity [GO:0033889]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; lysosome [GO:0005764]; arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-sulfoglucosamine-3-sulfatase activity [GO:0033889]; sulfur compound metabolic process [GO:0006790]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:12461688, ECO:0000269|PubMed:18283100}. Note=The 63-kDa precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes, most likely the endoplasmic reticulum. In contrast, proteolytically processed fragments of 34-, 18- and 10-kDa are found in lysosomal fractions and lose their membrane association. {ECO:0000250|UniProtKB:Q3TYD4}.
Q96EG3	reviewed	ZN837_HUMAN	Zinc finger protein 837	ZNF837	Homo sapiens (Human)	531	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96EH3	reviewed	MASU1_HUMAN	Mitochondrial assembly of ribosomal large subunit protein 1	MALSU1 C7orf30	Homo sapiens (Human)	234	FUNCTION: Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548). May function as a ribosomal silencing factor (Probable). {ECO:0000269|PubMed:22238375, ECO:0000269|PubMed:22238376, ECO:0000269|PubMed:23171548, ECO:0000305|PubMed:22829778, ECO:0000305|PubMed:28892042}.		negative regulation of mitochondrial translation [GO:0070130]; negative regulation of ribosome biogenesis [GO:0090071]; negative regulation of translation [GO:0017148]; ribosomal large subunit biogenesis [GO:0042273]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	mitochondrial large ribosomal subunit binding [GO:0140978]; ribosomal large subunit binding [GO:0043023]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; mitochondrial large ribosomal subunit binding [GO:0140978]; ribosomal large subunit binding [GO:0043023]; negative regulation of mitochondrial translation [GO:0070130]; negative regulation of ribosome biogenesis [GO:0090071]; negative regulation of translation [GO:0017148]; ribosomal large subunit biogenesis [GO:0042273]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:16548050, ECO:0000269|PubMed:22238375, ECO:0000269|PubMed:22238376, ECO:0000269|PubMed:22829778, ECO:0000269|PubMed:23171548, ECO:0000305|PubMed:28892042}. Note=Colocalizes with MRPL12 and/or MRPL14. {ECO:0000269|PubMed:22238375, ECO:0000269|PubMed:22829778}.
Q96EK4	reviewed	THA11_HUMAN	THAP domain-containing protein 11	THAP11 HRIHFB2206	Homo sapiens (Human)	314	FUNCTION: Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity). {ECO:0000250}.		cell population proliferation [GO:0008283]; electron transport chain [GO:0022900]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; regulation of mitochondrial transcription [GO:1903108]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; cell population proliferation [GO:0008283]; electron transport chain [GO:0022900]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; regulation of mitochondrial transcription [GO:1903108]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9853615}. Cytoplasm {ECO:0000250}. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus. {ECO:0000250}.
Q96EK5	reviewed	KBP_HUMAN	KIF-binding protein (KIF1-binding protein) (Kinesin family binding protein)	KIFBP KBP KIAA1279 KIF1BP	Homo sapiens (Human)	621	FUNCTION: Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. {ECO:0000269|PubMed:16225668, ECO:0000269|PubMed:20621975, ECO:0000269|PubMed:23427148}.		central nervous system projection neuron axonogenesis [GO:0021952]; in utero embryonic development [GO:0001701]; microtubule cytoskeleton organization [GO:0000226]; mitochondrial transport [GO:0006839]; neuron projection maintenance [GO:1990535]	cytoskeleton [GO:0005856]; mitochondrion [GO:0005739]	kinesin binding [GO:0019894]	cytoskeleton [GO:0005856]; mitochondrion [GO:0005739]; kinesin binding [GO:0019894]; central nervous system projection neuron axonogenesis [GO:0021952]; in utero embryonic development [GO:0001701]; microtubule cytoskeleton organization [GO:0000226]; mitochondrial transport [GO:0006839]; neuron projection maintenance [GO:1990535]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16225668, ECO:0000269|PubMed:20621975, ECO:0000269|PubMed:23427148}.
Q96EK6	reviewed	GNA1_HUMAN	Glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase)	GNPNAT1 GNA1	Homo sapiens (Human)	184			UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	glucosamine 6-phosphate N-acetyltransferase activity [GO:0004343]; identical protein binding [GO:0042802]; monosaccharide binding [GO:0048029]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; glucosamine 6-phosphate N-acetyltransferase activity [GO:0004343]; identical protein binding [GO:0042802]; monosaccharide binding [GO:0048029]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q96EL1	reviewed	INKA1_HUMAN	PAK4-inhibitor INKA1 (Induced in neural crest by AP2-alpha protein homolog) (Inca) (Inka-box actin regulator 1)	INKA1 C3orf54 FAM212A	Homo sapiens (Human)	287	FUNCTION: Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847). {ECO:0000269|PubMed:26607847}.			cytoplasm [GO:0005737]; nucleus [GO:0005634]	protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26607847}. Cytoplasm {ECO:0000269|PubMed:26607847}. Note=Mainly nuclear (PubMed:26607847). Relocalizes to the cytoplasm following interaction with PAK4 (PubMed:26607847). {ECO:0000269|PubMed:26607847}.
Q96EL3	reviewed	RM53_HUMAN	Large ribosomal subunit protein mL53 (39S ribosomal protein L53, mitochondrial) (L53mt) (MRP-L53)	MRPL53	Homo sapiens (Human)	112			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q96EM0	reviewed	T3HPD_HUMAN	Trans-3-hydroxy-L-proline dehydratase (EC 4.2.1.77) (Trans-L-3-hydroxyproline dehydratase)	L3HYPDH C14orf149	Homo sapiens (Human)	354	FUNCTION: Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. {ECO:0000269|PubMed:22528483}.	MISCELLANEOUS: In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity. {ECO:0000305|PubMed:22528483}.			hydro-lyase activity [GO:0016836]; trans-L-3-hydroxyproline dehydratase activity [GO:0050346]	hydro-lyase activity [GO:0016836]; trans-L-3-hydroxyproline dehydratase activity [GO:0050346]	
Q96EN8	reviewed	MOCOS_HUMAN	Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase)	MOCOS	Homo sapiens (Human)	888	FUNCTION: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime. {ECO:0000255|HAMAP-Rule:MF_03050, ECO:0000269|PubMed:16973608}.		Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor biosynthetic process [GO:0032324]; molybdopterin cofactor metabolic process [GO:0043545]	cytosol [GO:0005829]	lyase activity [GO:0016829]; Mo-molybdopterin cofactor sulfurase activity [GO:0008265]; molybdenum cofactor sulfurtransferase activity [GO:0102867]; molybdenum ion binding [GO:0030151]; pyridoxal phosphate binding [GO:0030170]	cytosol [GO:0005829]; lyase activity [GO:0016829]; Mo-molybdopterin cofactor sulfurase activity [GO:0008265]; molybdenum cofactor sulfurtransferase activity [GO:0102867]; molybdenum ion binding [GO:0030151]; pyridoxal phosphate binding [GO:0030170]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor biosynthetic process [GO:0032324]; molybdopterin cofactor metabolic process [GO:0043545]	
Q96EP0	reviewed	RNF31_HUMAN	E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)	RNF31 ZIBRA	Homo sapiens (Human)	1072	FUNCTION: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28481331, PubMed:28189684). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}.		CD40 signaling pathway [GO:0023035]; defense response to bacterium [GO:0042742]; negative regulation of necroptotic process [GO:0060546]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of xenophagy [GO:1904417]; protein linear polyubiquitination [GO:0097039]; protein polyubiquitination [GO:0000209]; T cell receptor signaling pathway [GO:0050852]	CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; LUBAC complex [GO:0071797]	identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; linear polyubiquitin binding [GO:1990450]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; LUBAC complex [GO:0071797]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; linear polyubiquitin binding [GO:1990450]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; CD40 signaling pathway [GO:0023035]; defense response to bacterium [GO:0042742]; negative regulation of necroptotic process [GO:0060546]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of xenophagy [GO:1904417]; protein linear polyubiquitination [GO:0097039]; protein polyubiquitination [GO:0000209]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q924T7}.
Q96EP1	reviewed	CHFR_HUMAN	E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196) (RING-type E3 ubiquitin transferase CHFR)	CHFR RNF196	Homo sapiens (Human)	664	FUNCTION: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. {ECO:0000269|PubMed:10935642, ECO:0000269|PubMed:11807090, ECO:0000269|PubMed:11912157, ECO:0000269|PubMed:14562038, ECO:0000269|PubMed:14694445, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19182791}.	MISCELLANEOUS: CHFR is silenced in many primary cancers because of CpG methylation and deacetylated histones on its promoter region. This however raises the question of whether CHFR silencing is a consequence or a cause of primary cancers.	cell division [GO:0051301]; meiotic spindle checkpoint signaling [GO:0044779]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	nucleus [GO:0005634]; PML body [GO:0016605]	metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	nucleus [GO:0005634]; PML body [GO:0016605]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cell division [GO:0051301]; meiotic spindle checkpoint signaling [GO:0044779]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000269|PubMed:11912157, ECO:0000269|PubMed:15467728, ECO:0000269|PubMed:18172500}.
Q96EP5	reviewed	DAZP1_HUMAN	DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1)	DAZAP1	Homo sapiens (Human)	407	FUNCTION: RNA-binding protein, which may be required during spermatogenesis.		cell differentiation [GO:0030154]; fibroblast proliferation [GO:0048144]; maternal placenta development [GO:0001893]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]	cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; cell differentiation [GO:0030154]; fibroblast proliferation [GO:0048144]; maternal placenta development [GO:0001893]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22001406}. Nucleus {ECO:0000269|PubMed:22001406}. Note=Predominantly cytoplasmic (By similarity). Nuclear at some stages of spermatozoides development. In midpachytene spermatocytes, it is localized in both the cytoplasm and the nuclei and is clearly excluded from the sex vesicles. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm (By similarity). {ECO:0000250}.
Q96EP9	reviewed	NTCP4_HUMAN	Sodium/bile acid cotransporter 4 (Na(+)/bile acid cotransporter 4) (Solute carrier family 10 member 4)	SLC10A4	Homo sapiens (Human)	437	FUNCTION: Transporter for bile acids. {ECO:0000269|PubMed:23589386}.		bile acid and bile salt transport [GO:0015721]	plasma membrane [GO:0005886]	bile acid:sodium symporter activity [GO:0008508]	plasma membrane [GO:0005886]; bile acid:sodium symporter activity [GO:0008508]; bile acid and bile salt transport [GO:0015721]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23589386}; Multi-pass membrane protein {ECO:0000269|PubMed:23589386}.
Q96EQ0	reviewed	SGTB_HUMAN	Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2)	SGTB SGT2	Homo sapiens (Human)	304	FUNCTION: Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. {ECO:0000250}.		post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]	membrane [GO:0016020]; TRC complex [GO:0072380]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]	membrane [GO:0016020]; TRC complex [GO:0072380]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]	
Q96EQ8	reviewed	RN125_HUMAN	E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)	RNF125	Homo sapiens (Human)	232	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525). {ECO:0000269|PubMed:15843525, ECO:0000269|PubMed:17460044, ECO:0000269|PubMed:17643463, ECO:0000269|PubMed:25591766, ECO:0000269|PubMed:26027934, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:27411375}.		adaptive immune response [GO:0002250]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	p53 binding [GO:0002039]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; p53 binding [GO:0002039]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; adaptive immune response [GO:0002250]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17990982}; Lipid-anchor {ECO:0000269|PubMed:17990982}. Note=Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane. {ECO:0000269|PubMed:17990982}.
Q96ER9	reviewed	MITOK_HUMAN	Mitochondrial potassium channel (MITOK) (Coiled-coil domain-containing protein 51)	CCDC51 MITOK	Homo sapiens (Human)	411	FUNCTION: Mitochondrial potassium channel located in the mitochondrial inner membrane (PubMed:31435016). Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (PubMed:31435016). May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume (PubMed:31435016). {ECO:0000269|PubMed:31435016}.		cell volume homeostasis [GO:0006884]; mitochondrial potassium ion transmembrane transport [GO:0140141]; potassium ion transmembrane transport [GO:0071805]	mitochondrial ATP-gated potassium channel complex [GO:0062157]; mitochondrial inner membrane [GO:0005743]	mitochondrial ATP-gated potassium channel activity [GO:0062156]	mitochondrial ATP-gated potassium channel complex [GO:0062157]; mitochondrial inner membrane [GO:0005743]; mitochondrial ATP-gated potassium channel activity [GO:0062156]; cell volume homeostasis [GO:0006884]; mitochondrial potassium ion transmembrane transport [GO:0140141]; potassium ion transmembrane transport [GO:0071805]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:31435016}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane {ECO:0000269|PubMed:31435016}; Multi-pass membrane protein {ECO:0000255}.
Q96ES7	reviewed	SGF29_HUMAN	SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29)	SGF29 CCDC101	Homo sapiens (Human)	293	FUNCTION: Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity). {ECO:0000250|UniProtKB:Q9DA08, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:21685874, ECO:0000269|PubMed:23894581, ECO:0000269|PubMed:26421618, ECO:0000269|PubMed:26578293}.		establishment of protein localization to chromatin [GO:0071169]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; transcription initiation-coupled chromatin remodeling [GO:0045815]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461]	methylated histone binding [GO:0035064]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461]; methylated histone binding [GO:0035064]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0C606}.
Q96EU6	reviewed	RRP36_HUMAN	Ribosomal RNA processing protein 36 homolog	RRP36 C6orf153 HSPC253	Homo sapiens (Human)	259	FUNCTION: Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. {ECO:0000269|PubMed:20038530}.	MISCELLANEOUS: Meningioma antigen.	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:20038530}. Note=Concentrated in the fibrillar region of the nucleolus.
Q96EU7	reviewed	C1GLC_HUMAN	C1GALT1-specific chaperone 1 (C38H2-like protein 1) (C38H2-L1) (Core 1 beta1,3-galactosyltransferase 2) (C1Gal-T2) (C1GalT2) (Core 1 beta3-Gal-T2) (Core 1 beta3-galactosyltransferase-specific molecular chaperone)	C1GALT1C1 COSMC HSPC067 MSTP143 UNQ273/PRO310	Homo sapiens (Human)	318	FUNCTION: Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1). {ECO:0000269|PubMed:12464682}.	MISCELLANEOUS: Defects in C1GALT1C1 in Ag104A cell line create a tumor-specific glycopeptidic neo-epitope. This epitope induces a high-affinity, highly specific, syngeneic monoclonal antibody. This is caused by the abolition of function of a glycosyltransferase, disrupting O-glycan Core 1 synthesis.	platelet activation [GO:0030168]; platelet morphogenesis [GO:0036344]; protein O-linked glycosylation [GO:0006493]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263]; platelet activation [GO:0030168]; platelet morphogenesis [GO:0036344]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q96EV8	reviewed	DTBP1_HUMAN	Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1) (Hermansky-Pudlak syndrome 7 protein) (HPS7 protein)	DTNBP1 BLOC1S8 My031	Homo sapiens (Human)	351	FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. {ECO:0000269|PubMed:15345706, ECO:0000269|PubMed:16837549, ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:17989303, ECO:0000269|PubMed:19094965, ECO:0000269|PubMed:20180862, ECO:0000269|PubMed:20921223}.	MISCELLANEOUS: [Isoform 1]: Major isoform.; MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; dendrite morphogenesis [GO:0048813]; melanosome organization [GO:0032438]; negative regulation of dendritic spine morphogenesis [GO:0061002]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; platelet dense granule organization [GO:0060155]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of dopamine secretion [GO:0014059]; regulation of synaptic vesicle exocytosis [GO:2000300]; retina development in camera-type eye [GO:0060041]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; melanosome membrane [GO:0033162]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle membrane [GO:0030672]		axon [GO:0030424]; axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; melanosome membrane [GO:0033162]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle membrane [GO:0030672]; actin cytoskeleton organization [GO:0030036]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; dendrite morphogenesis [GO:0048813]; melanosome organization [GO:0032438]; negative regulation of dendritic spine morphogenesis [GO:0061002]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; platelet dense granule organization [GO:0060155]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of dopamine secretion [GO:0014059]; regulation of synaptic vesicle exocytosis [GO:2000300]; retina development in camera-type eye [GO:0060041]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:21390302}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:21390302}; Peripheral membrane protein {ECO:0000269|PubMed:21390302}; Cytoplasmic side {ECO:0000269|PubMed:21390302}. Endosome membrane {ECO:0000269|PubMed:21390302}; Peripheral membrane protein {ECO:0000269|PubMed:21390302}; Cytoplasmic side {ECO:0000269|PubMed:21390302}. Melanosome membrane {ECO:0000269|PubMed:21390302}; Peripheral membrane protein {ECO:0000269|PubMed:21390302}; Cytoplasmic side {ECO:0000269|PubMed:21390302}. Postsynaptic density {ECO:0000269|PubMed:21390302}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000269|PubMed:21390302}. Note=Mainly cytoplasmic but shuttles between the cytoplasm and nucleus. Exported out of the nucleus via its NES in a XPO1-dependent manner. Nuclear localization is required for regulation of the expression of genes such as SYN1. Detected in neuron cell bodies, axons and dendrites. Mainly located to the postsynaptic density. Detected at tubulovesicular elements in the vicinity of the Golgi apparatus and of melanosomes. Occasionally detected at the membrane of pigmented melanosomes in cultured melanoma cells. The BLOC-1 complex associates with the BLOC-2 complex in early endosome-associated tubules.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:21390302}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:21390302}; Peripheral membrane protein {ECO:0000269|PubMed:21390302}; Cytoplasmic side {ECO:0000269|PubMed:21390302}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:21390302}; Peripheral membrane protein {ECO:0000269|PubMed:21390302}; Cytoplasmic side {ECO:0000269|PubMed:21390302}. Endosome membrane {ECO:0000269|PubMed:21390302}; Peripheral membrane protein {ECO:0000269|PubMed:21390302}; Cytoplasmic side {ECO:0000269|PubMed:21390302}. Melanosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Postsynaptic cell membrane {ECO:0000269|PubMed:21390302}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000269|PubMed:21390302}. Note=Shuttles between the cytoplasm and nucleus. Exported out of the nucleus via its NES in a XPO1-dependent manner. Nuclear localization is required for regulation of the expression of genes such as SYN1. Mainly expressed in the dendritic spine. Predominantly a synaptic vesicle isoform but also highly expressed in the nucleus. The BLOC-1 complex associates with the BLOC-2 complex in early endosome-associated tubules. Associated with the AP-3 complex at presynaptic terminals.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:21390302}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:21390302}; Peripheral membrane protein {ECO:0000269|PubMed:21390302}; Cytoplasmic side {ECO:0000269|PubMed:21390302}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:21390302}; Peripheral membrane protein {ECO:0000269|PubMed:21390302}; Cytoplasmic side {ECO:0000269|PubMed:21390302}. Endosome membrane {ECO:0000269|PubMed:21390302}; Peripheral membrane protein {ECO:0000269|PubMed:21390302}; Cytoplasmic side {ECO:0000269|PubMed:21390302}. Melanosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Postsynaptic cell membrane {ECO:0000269|PubMed:21390302}. Endoplasmic reticulum {ECO:0000250}. Note=Exclusivley cytoplasmic. Predominantly found in the postsynaptic density (PSD). Little association with synaptic vesicles. The BLOC-1 complex associates with the BLOC-2 complex in early endosome-associated tubules. Associated with the AP-3 complex at presynaptic terminals.
Q96EW2	reviewed	HBAP1_HUMAN	HSPB1-associated protein 1 (27 kDa heat shock protein-associated protein 1) (Protein associated with small stress protein 1)	HSPBAP1 PASS1	Homo sapiens (Human)	488	FUNCTION: May play a role in cellular stress response. {ECO:0000250}.			cytoplasm [GO:0005737]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]	cytoplasm [GO:0005737]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96EX2	reviewed	RNFT2_HUMAN	E3 ubiquitin-protein ligase RNFT2 (RING finger and transmembrane domain-containing protein 2) (Transmembrane protein 118)	RNFT2 TMEM118	Homo sapiens (Human)	444	FUNCTION: E3 ubiquitin-protein ligase that negatively regulates IL3-dependent cellular responses through IL3RA ubiquitination and degradation by the proteasome, having an anti-inflammatory effect. {ECO:0000269|PubMed:31990690}.		positive regulation of ERAD pathway [GO:1904294]	membrane [GO:0016020]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of ERAD pathway [GO:1904294]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96EX3	reviewed	DC2I2_HUMAN	Cytoplasmic dynein 2 intermediate chain 2 (Dynein 2 intermediate chain 2) (WD repeat-containing protein 34)	DYNC2I2 WDR34	Homo sapiens (Human)	536	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:25205765, PubMed:29742051). DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis (PubMed:30649997, PubMed:29742051, PubMed:30320547). Required also to maintain a functional transition zone (PubMed:30320547). {ECO:0000269|PubMed:25205765, ECO:0000269|PubMed:29742051, ECO:0000269|PubMed:30320547, ECO:0000269|PubMed:30649997}.; FUNCTION: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation. {ECO:0000269|PubMed:19521662, ECO:0000269|PubMed:24183449}.		cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]	axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary plasm [GO:0097014]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; filopodium [GO:0030175]	dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]	axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary plasm [GO:0097014]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; filopodium [GO:0030175]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19521662, ECO:0000269|PubMed:25205765}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19521662, ECO:0000269|PubMed:25205765}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19521662}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25205765}. Cell projection, cilium {ECO:0000269|PubMed:25205765}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q5U4F6}. Note=Concentrates around the centrioles and basal bodies also showing axonemal staining. {ECO:0000250|UniProtKB:Q5U4F6}.
Q96EY1	reviewed	DNJA3_HUMAN	DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)	DNAJA3 HCA57 TID1	Homo sapiens (Human)	480	FUNCTION: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation-induced cell death of T cells [GO:0006924]; cellular senescence [GO:0090398]; mitochondrial DNA replication [GO:0006264]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; neuromuscular junction development [GO:0007528]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell proliferation [GO:0042102]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; response to type II interferon [GO:0034341]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; small GTPase mediated signal transduction [GO:0007264]; T cell differentiation in thymus [GO:0033077]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; postsynaptic membrane [GO:0045211]	ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; GTPase regulator activity [GO:0030695]; Hsp70 protein binding [GO:0030544]; IkappaB kinase complex binding [GO:0106137]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; type II interferon receptor binding [GO:0005133]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; postsynaptic membrane [GO:0045211]; ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; GTPase regulator activity [GO:0030695]; Hsp70 protein binding [GO:0030544]; IkappaB kinase complex binding [GO:0106137]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; type II interferon receptor binding [GO:0005133]; unfolded protein binding [GO:0051082]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation-induced cell death of T cells [GO:0006924]; cellular senescence [GO:0090398]; mitochondrial DNA replication [GO:0006264]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; neuromuscular junction development [GO:0007528]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell proliferation [GO:0042102]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; response to type II interferon [GO:0034341]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; small GTPase mediated signal transduction [GO:0007264]; T cell differentiation in thymus [GO:0033077]	SUBCELLULAR LOCATION: Mitochondrion matrix. Cytoplasm, cytosol {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. {ECO:0000250}.
Q96EY4	reviewed	TMA16_HUMAN	Translation machinery-associated protein 16	TMA16 C4orf43	Homo sapiens (Human)	203	FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. {ECO:0000269|PubMed:32669547}.		ribosomal large subunit biogenesis [GO:0042273]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	preribosome binding [GO:1990275]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome binding [GO:1990275]; ribosomal large subunit biogenesis [GO:0042273]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:32669547}.
Q96EY5	reviewed	MB12A_HUMAN	Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A)	MVB12A CFBP FAM125A	Homo sapiens (Human)	273	FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}.	MISCELLANEOUS: [Isoform 2]: Does not interact with CD2AP. {ECO:0000305}.	endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; receptor catabolic process [GO:0032801]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]; virus maturation [GO:0019075]	centrosome [GO:0005813]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; nucleus [GO:0005634]; vesicle [GO:0031982]	lipid binding [GO:0008289]; SH3 domain binding [GO:0017124]; ubiquitin binding [GO:0043130]	centrosome [GO:0005813]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; nucleus [GO:0005634]; vesicle [GO:0031982]; lipid binding [GO:0008289]; SH3 domain binding [GO:0017124]; ubiquitin binding [GO:0043130]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; receptor catabolic process [GO:0032801]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]; virus maturation [GO:0019075]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Colocalizes with F-actin. Some fraction may be nuclear.
Q96EY7	reviewed	PTCD3_HUMAN	Small ribosomal subunit protein mS39 (28S ribosomal protein S39, mitochondrial) (MRP-S39) (Pentatricopeptide repeat domain-containing protein 3, mitochondrial) (Transformation-related gene 15 protein) (TRG-15)	PTCD3 MRPS39 TRG15	Homo sapiens (Human)	689	FUNCTION: Mitochondrial RNA-binding protein that has a role in mitochondrial translation. {ECO:0000269|PubMed:19427859}.		mitochondrial translation [GO:0032543]; regulation of translation [GO:0006417]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; mitochondrial translation [GO:0032543]; regulation of translation [GO:0006417]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19427859, ECO:0000269|PubMed:23908630}.
Q96EY8	reviewed	MMAB_HUMAN	Corrinoid adenosyltransferase MMAB (EC 2.5.1.-) (ATP:co(I)rrinoid adenosyltransferase MMAB) (Methylmalonic aciduria type B protein)	MMAB	Homo sapiens (Human)	250	FUNCTION: Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion (PubMed:12514191). Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA (Probable). {ECO:0000269|PubMed:12514191, ECO:0000305|PubMed:28497574}.		cobalamin metabolic process [GO:0009235]	mitochondrial matrix [GO:0005759]	ATP binding [GO:0005524]; cobalamin binding [GO:0031419]; corrinoid adenosyltransferase activity [GO:0008817]; transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765]	mitochondrial matrix [GO:0005759]; ATP binding [GO:0005524]; cobalamin binding [GO:0031419]; corrinoid adenosyltransferase activity [GO:0008817]; transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765]; cobalamin metabolic process [GO:0009235]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q96EZ8	reviewed	MCRS1_HUMAN	Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2)	MCRS1 INO80Q MSP58	Homo sapiens (Human)	462	FUNCTION: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). {ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852}.	MISCELLANEOUS: [Isoform 3]: May be due to intron retention. {ECO:0000305}.	chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein modification process [GO:0036211]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; histone acetyltransferase complex [GO:0000123]; Ino80 complex [GO:0031011]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; polysome [GO:0005844]	G-quadruplex RNA binding [GO:0002151]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; telomerase inhibitor activity [GO:0010521]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; histone acetyltransferase complex [GO:0000123]; Ino80 complex [GO:0031011]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; polysome [GO:0005844]; G-quadruplex RNA binding [GO:0002151]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; telomerase inhibitor activity [GO:0010521]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein modification process [GO:0036211]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:18922472, ECO:0000269|PubMed:20018852}. Nucleus, nucleolus {ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:9654073}. Cytoplasm {ECO:0000269|PubMed:16571602}. Note=In microspherules in the nucleolus. {ECO:0000269|PubMed:9654073}.
Q96F05	reviewed	CK024_HUMAN	Uncharacterized protein C11orf24 (Protein DM4E3)	C11orf24 FP2568 UNQ1872/PRO4315	Homo sapiens (Human)	449				Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24312644}; Single-pass type I membrane protein {ECO:0000269|PubMed:24312644}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:24312644}; Single-pass type I membrane protein {ECO:0000269|PubMed:24312644}. Note=Cycles to the plasma membrane via endosomes in a pH sensitive manner. Associated with Rab6-positive vesicles.
Q96F07	reviewed	CYFP2_HUMAN	Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)	CYFIP2 KIAA1168 PIR121	Homo sapiens (Human)	1278	FUNCTION: Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:15048733, ECO:0000269|PubMed:17245118}.		activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; cell-cell adhesion [GO:0098609]; dendrite extension [GO:0097484]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of proteolysis [GO:0045862]; regulation of actin filament polymerization [GO:0030833]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCAR complex [GO:0031209]; synapse [GO:0045202]	small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCAR complex [GO:0031209]; synapse [GO:0045202]; small GTPase binding [GO:0031267]; activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; cell-cell adhesion [GO:0098609]; dendrite extension [GO:0097484]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of proteolysis [GO:0045862]; regulation of actin filament polymerization [GO:0030833]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:17245118}. Nucleus {ECO:0000269|PubMed:17245118}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q5SQX6}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q5SQX6}. Note=Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118). {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:17245118}.
Q96F10	reviewed	SAT2_HUMAN	Thialysine N-epsilon-acetyltransferase (EC 2.3.1.-) (Diamine acetyltransferase 2) (EC 2.3.1.57) (Spermidine/spermine N(1)-acetyltransferase 2) (SSAT-2)	SAT2 SSAT2	Homo sapiens (Human)	170	FUNCTION: Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur (PubMed:15283699). May also catalyze acetylation of polyamines, such as norspermidine, spermidine or spermine (PubMed:12803540). However, ability to acetylate polyamines is weak, suggesting that it does not act as a diamine acetyltransferase in vivo (PubMed:15283699). {ECO:0000269|PubMed:12803540, ECO:0000269|PubMed:15283699}.		nor-spermidine metabolic process [GO:0046204]; putrescine acetylation [GO:0032920]; spermidine acetylation [GO:0032918]; spermine acetylation [GO:0032919]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	diamine N-acetyltransferase activity [GO:0004145]; identical protein binding [GO:0042802]; N-acetyltransferase activity [GO:0008080]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; diamine N-acetyltransferase activity [GO:0004145]; identical protein binding [GO:0042802]; N-acetyltransferase activity [GO:0008080]; nor-spermidine metabolic process [GO:0046204]; putrescine acetylation [GO:0032920]; spermidine acetylation [GO:0032918]; spermine acetylation [GO:0032919]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:12803540}. Note=Intracellular organelles. {ECO:0000305|PubMed:12803540}.
Q96F15	reviewed	GIMA5_HUMAN	GTPase IMAP family member 5 (Immune-associated nucleotide-binding protein 5) (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated nucleotide 5 protein) (IAN-5) (hIAN5) (Immunity-associated protein 3)	GIMAP5 IAN4L1 IAN5 IMAP3	Homo sapiens (Human)	307	FUNCTION: Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8BWF2, ECO:0000250|UniProtKB:Q8K3L6, ECO:0000269|PubMed:29382851}.			lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]	GTP binding [GO:0005525]	lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; GTP binding [GO:0005525]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:21487483, ECO:0000269|PubMed:29382851}; Single-pass type IV membrane protein {ECO:0000305}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:21487483}; Single-pass type IV membrane protein {ECO:0000305}. Endosome membrane {ECO:0000250|UniProtKB:Q8K3L6}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8K3L6}. Note=The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications. {ECO:0000305|PubMed:14724691, ECO:0000305|PubMed:21487483}.
Q96F24	reviewed	NRBF2_HUMAN	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR)	NRBF2 COPR	Homo sapiens (Human)	287	FUNCTION: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). {ECO:0000269|PubMed:15610520}.; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VCQ3, ECO:0000269|PubMed:24785657, ECO:0000269|PubMed:25086043}.		autophagy [GO:0006914]; response to endoplasmic reticulum stress [GO:0034976]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]		autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; autophagy [GO:0006914]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9QYK3}. Cytoplasm {ECO:0000250|UniProtKB:Q9QYK3}. Cytoplasmic vesicle {ECO:0000269|PubMed:25086043}. Cytoplasmic vesicle, autophagosome {ECO:0000305}.
Q96F25	reviewed	ALG14_HUMAN	UDP-N-acetylglucosamine transferase subunit ALG14 homolog	ALG14	Homo sapiens (Human)	216	FUNCTION: Involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER. {ECO:0000269|PubMed:16100110}.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]	endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]; UDP-N-acetylglucosamine transferase complex [GO:0043541]		endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]; UDP-N-acetylglucosamine transferase complex [GO:0043541]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P38242}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:P38242}; Single-pass membrane protein {ECO:0000255}.
Q96F44	reviewed	TRI11_HUMAN	E3 ubiquitin-protein ligase TRIM11 (EC 2.3.2.27) (Protein BIA1) (RING finger protein 92) (Tripartite motif-containing protein 11)	TRIM11 RNF92	Homo sapiens (Human)	468	FUNCTION: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX (By similarity). Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis (By similarity). May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences (By similarity). May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (By similarity). Mediates MED15 ubiquitination leading to proteasomal degradation (PubMed:16904669). May contribute to the innate restriction of retroviruses (PubMed:18248090). Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression (PubMed:18248090). Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain (PubMed:18248090). May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle (PubMed:18248090). Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2 (PubMed:27498865). Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (PubMed:27498865). {ECO:0000250|UniProtKB:Q99PQ2, ECO:0000269|PubMed:16904669, ECO:0000269|PubMed:18248090, ECO:0000269|PubMed:27498865}.	MISCELLANEOUS: [Isoform 3]: May be due to competing acceptor splice site. {ECO:0000305}.	innate immune response [GO:0045087]; negative regulation of AIM2 inflammasome complex assembly [GO:0140972]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neurogenesis [GO:0050768]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of viral entry into host cell [GO:0046598]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; suppression of viral release by host [GO:0044790]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; negative regulation of AIM2 inflammasome complex assembly [GO:0140972]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neurogenesis [GO:0050768]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of viral entry into host cell [GO:0046598]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; suppression of viral release by host [GO:0044790]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16904669, ECO:0000269|PubMed:18248090}. Nucleus {ECO:0000269|PubMed:16904669}.
Q96F45	reviewed	ZN503_HUMAN	Zinc finger protein 503	ZNF503 NOLZ1	Homo sapiens (Human)	646	FUNCTION: May function as a transcriptional repressor. {ECO:0000250}.		G1 to G0 transition involved in cell differentiation [GO:0070315]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; neural precursor cell proliferation [GO:0061351]	nucleus [GO:0005634]	metal ion binding [GO:0046872]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; G1 to G0 transition involved in cell differentiation [GO:0070315]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; neural precursor cell proliferation [GO:0061351]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96F46	reviewed	I17RA_HUMAN	Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217)	IL17RA IL17R	Homo sapiens (Human)	866	FUNCTION: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:24120361, PubMed:17911633, PubMed:18684971, PubMed:21350122). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). {ECO:0000250|UniProtKB:Q60943, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:9367539}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}.	MISCELLANEOUS: [Isoform 2]: Soluble isoform lacking the transmembrane segment. {ECO:0000305}.	cell surface receptor signaling pathway [GO:0007166]; defense response to fungus [GO:0050832]; fibroblast activation [GO:0072537]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; protein catabolic process [GO:0030163]; response to virus [GO:0009615]; T-helper 17 type immune response [GO:0072538]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	interleukin-17 receptor activity [GO:0030368]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; interleukin-17 receptor activity [GO:0030368]; signaling receptor binding [GO:0005102]; cell surface receptor signaling pathway [GO:0007166]; defense response to fungus [GO:0050832]; fibroblast activation [GO:0072537]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; protein catabolic process [GO:0030163]; response to virus [GO:0009615]; T-helper 17 type immune response [GO:0072538]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:17911633}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:24084331}.
Q96F81	reviewed	DISP1_HUMAN	Protein dispatched homolog 1	DISP1 DISPA	Homo sapiens (Human)	1524	FUNCTION: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404). {ECO:0000250|UniProtKB:Q3TDN0, ECO:0000269|PubMed:22902404}.		determination of left/right symmetry [GO:0007368]; diaphragm development [GO:0060539]; dorsal/ventral pattern formation [GO:0009953]; embryonic pattern specification [GO:0009880]; patched ligand maturation [GO:0007225]; peptide transport [GO:0015833]; protein homotrimerization [GO:0070207]; regulation of protein secretion [GO:0050708]; smoothened signaling pathway [GO:0007224]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]	peptide transmembrane transporter activity [GO:1904680]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; peptide transmembrane transporter activity [GO:1904680]; determination of left/right symmetry [GO:0007368]; diaphragm development [GO:0060539]; dorsal/ventral pattern formation [GO:0009953]; embryonic pattern specification [GO:0009880]; patched ligand maturation [GO:0007225]; peptide transport [GO:0015833]; protein homotrimerization [GO:0070207]; regulation of protein secretion [GO:0050708]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96F85	reviewed	CNRP1_HUMAN	CB1 cannabinoid receptor-interacting protein 1 (CRIP-1)	CNRIP1 C2orf32	Homo sapiens (Human)	164	FUNCTION: [Isoform 1]: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. {ECO:0000269|PubMed:17895407}.; FUNCTION: [Isoform 2]: Does not suppress cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. {ECO:0000269|PubMed:17895407}.		negative regulation of signaling receptor activity [GO:2000272]; regulation of signaling receptor activity [GO:0010469]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	type 1 cannabinoid receptor binding [GO:0031718]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; type 1 cannabinoid receptor binding [GO:0031718]; negative regulation of signaling receptor activity [GO:2000272]; regulation of signaling receptor activity [GO:0010469]	
Q96F86	reviewed	EDC3_HUMAN	Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1)	EDC3 LSM16 YJDC YJEFN2 PP844	Homo sapiens (Human)	508	FUNCTION: Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubMed:18678652, ECO:0000269|PubMed:25701870}.		deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; P-body assembly [GO:0033962]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; P-body [GO:0000932]	identical protein binding [GO:0042802]; mRNA binding [GO:0003729]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; P-body [GO:0000932]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; P-body assembly [GO:0033962]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:16364915}. Note=Processing bodies (PB).
Q96FA3	reviewed	PELI1_HUMAN	E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1)	PELI1 PRISM	Homo sapiens (Human)	418	FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). {ECO:0000269|PubMed:12496252, ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:29883609}.		negative regulation of necroptotic process [GO:0060546]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of necroptotic process [GO:0060544]; regulation of Toll signaling pathway [GO:0008592]; response to dsRNA [GO:0043331]; response to lipopolysaccharide [GO:0032496]; T cell proliferation [GO:0042098]	cytosol [GO:0005829]; nucleus [GO:0005634]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; negative regulation of necroptotic process [GO:0060546]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of necroptotic process [GO:0060544]; regulation of Toll signaling pathway [GO:0008592]; response to dsRNA [GO:0043331]; response to lipopolysaccharide [GO:0032496]; T cell proliferation [GO:0042098]	
Q96FC9	reviewed	DDX11_HUMAN	ATP-dependent DNA helicase DDX11 (EC 3.6.4.12) (CHL1-related protein 1) (hCHLR1) (DEAD/H-box protein 11) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2)	DDX11 CHL1 CHLR1 KRG2	Homo sapiens (Human)	970	FUNCTION: DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Cooperates also with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Also plays a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:9013641, PubMed:18499658, PubMed:22102414). {ECO:0000250|UniProtKB:Q6AXC6, ECO:0000269|PubMed:10648783, ECO:0000269|PubMed:17105772, ECO:0000269|PubMed:18499658, ECO:0000269|PubMed:20124417, ECO:0000269|PubMed:21854770, ECO:0000269|PubMed:22102414, ECO:0000269|PubMed:23116066, ECO:0000269|PubMed:23797032, ECO:0000269|PubMed:26089203, ECO:0000269|PubMed:26503245, ECO:0000269|PubMed:27477908}.; FUNCTION: (Microbial infection) Required for bovine papillomavirus type 1 regulatory protein E2 loading onto mitotic chromosomes during DNA replication for the viral genome to be maintained and segregated. {ECO:0000269|PubMed:17189189}.		cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to hydroxyurea [GO:0072711]; DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; establishment of sister chromatid cohesion [GO:0034085]; G-quadruplex DNA unwinding [GO:0044806]; negative regulation of protein binding [GO:0032091]; nucleolar chromatin organization [GO:1990700]; positive regulation of chromatin binding [GO:0035563]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of sister chromatid cohesion [GO:0045876]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; replication fork processing [GO:0031297]; sister chromatid cohesion [GO:0007062]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]	4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent activity, acting on RNA [GO:0008186]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; G-quadruplex DNA binding [GO:0051880]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; triplex DNA binding [GO:0045142]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]; 4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent activity, acting on RNA [GO:0008186]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; G-quadruplex DNA binding [GO:0051880]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; triplex DNA binding [GO:0045142]; cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to hydroxyurea [GO:0072711]; DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; establishment of sister chromatid cohesion [GO:0034085]; G-quadruplex DNA unwinding [GO:0044806]; negative regulation of protein binding [GO:0032091]; nucleolar chromatin organization [GO:1990700]; positive regulation of chromatin binding [GO:0035563]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of sister chromatid cohesion [GO:0045876]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; replication fork processing [GO:0031297]; sister chromatid cohesion [GO:0007062]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17105772}. Nucleus, nucleolus {ECO:0000269|PubMed:17105772, ECO:0000269|PubMed:26089203, ECO:0000269|PubMed:9013641}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:17105772}. Midbody {ECO:0000269|PubMed:17105772}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17105772}. Note=During the early stages of mitosis, localizes to condensed chromatin and is released from the chromatin with progression to metaphase. Also localizes to the spindle poles throughout mitosis and at the midbody at later stages of mitosis (metaphase to telophase) (PubMed:17105772). In interphase, colocalizes with nucleolin in the nucleolus (PubMed:26089203). {ECO:0000269|PubMed:17105772, ECO:0000269|PubMed:26089203}.; SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:17189189}. Note=(Microbial infection) Colocalizes with bovine papillomavirus type 1 regulatory protein E2 on mitotic chromosomes at early stages of mitosis. {ECO:0000269|PubMed:17189189}.
Q96FE5	reviewed	LIGO1_HUMAN	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)	LINGO1 LERN1 LRRN6A UNQ201/PRO227	Homo sapiens (Human)	620	FUNCTION: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). {ECO:0000250|UniProtKB:Q9D1T0, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:15694321, ECO:0000269|PubMed:15895088}.			extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	epidermal growth factor receptor binding [GO:0005154]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; epidermal growth factor receptor binding [GO:0005154]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9D1T0}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D1T0}.
Q96FE7	reviewed	P3IP1_HUMAN	Phosphoinositide-3-kinase-interacting protein 1 (PI3K-interacting protein 1) (Kringle domain-containing protein HGFL)	PIK3IP1 HGFL	Homo sapiens (Human)	263	FUNCTION: Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity. {ECO:0000250|UniProtKB:Q7TMJ8}.		negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	endopeptidase activity [GO:0004175]; phosphatidylinositol 3-kinase catalytic subunit binding [GO:0036313]; signaling receptor binding [GO:0005102]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; phosphatidylinositol 3-kinase catalytic subunit binding [GO:0036313]; signaling receptor binding [GO:0005102]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19088825}; Single-pass type I membrane protein {ECO:0000255}.
Q96FF9	reviewed	CDCA5_HUMAN	Sororin (Cell division cycle-associated protein 5) (p35)	CDCA5	Homo sapiens (Human)	252	FUNCTION: Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}.	MISCELLANEOUS: Named sororin after the Latin word 'soror', which means 'sister', because of its critical role in sister chromatid cohesion.	cell division [GO:0051301]; double-strand break repair [GO:0006302]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid cohesion [GO:0007064]; positive regulation of exit from mitosis [GO:0031536]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; protein-containing complex binding [GO:0044877]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; protein-containing complex binding [GO:0044877]; cell division [GO:0051301]; double-strand break repair [GO:0006302]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid cohesion [GO:0007064]; positive regulation of exit from mitosis [GO:0031536]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15837422}. Chromosome {ECO:0000269|PubMed:15837422}. Cytoplasm {ECO:0000269|PubMed:15837422}. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.
Q96FG2	reviewed	ELMD3_HUMAN	ELMO domain-containing protein 3 (RNA-binding motif and ELMO domain-containing protein 1) (RNA-binding motif protein 29) (RNA-binding protein 29)	ELMOD3 RBED1 RBM29 PP4068	Homo sapiens (Human)	381	FUNCTION: Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity. {ECO:0000269|PubMed:24039609}.			cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; kinocilium [GO:0060091]; stereocilium [GO:0032420]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; kinocilium [GO:0060091]; stereocilium [GO:0032420]	SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000269|PubMed:24039609}. Cell projection, kinocilium {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24039609, ECO:0000269|PubMed:29713870}. Note=Also present in the cuticular plate of auditory hair cells. Expressed along the length of the stereocilia, but excluded from the very tip (By similarity). Colocalizes with F-actin cytoskeleton. {ECO:0000269|PubMed:29713870}.
Q96FI4	reviewed	NEIL1_HUMAN	Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1)	NEIL1	Homo sapiens (Human)	390	FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}.		base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; depyrimidination [GO:0045008]; negative regulation of nuclease activity [GO:0032074]; response to oxidative stress [GO:0006979]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; zinc ion binding [GO:0008270]; base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; depyrimidination [GO:0045008]; negative regulation of nuclease activity [GO:0032074]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17556049}. Nucleus {ECO:0000269|PubMed:17556049}. Chromosome {ECO:0000269|PubMed:17556049}. Note=During mitosis, associates with centrosomes and condensed chromatin.
Q96FJ0	reviewed	STALP_HUMAN	AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1)	STAMBPL1 AMSHLP KIAA1373	Homo sapiens (Human)	436	FUNCTION: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443). {ECO:0000269|PubMed:18758443, ECO:0000269|PubMed:35114100}.		cellular response to leucine [GO:0071233]; positive regulation of TORC1 signaling [GO:1904263]; proteolysis [GO:0006508]	cytosol [GO:0005829]; endosome [GO:0005768]; membrane [GO:0016020]	K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]	cytosol [GO:0005829]; endosome [GO:0005768]; membrane [GO:0016020]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; cellular response to leucine [GO:0071233]; positive regulation of TORC1 signaling [GO:1904263]; proteolysis [GO:0006508]	
Q96FJ2	reviewed	DYL2_HUMAN	Dynein light chain 2, cytoplasmic (8 kDa dynein light chain b) (DLC8b) (Dynein light chain LC8-type 2)	DYNLL2 DLC2	Homo sapiens (Human)	89	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). {ECO:0000250}.		microtubule-based process [GO:0007017]	9+0 non-motile cilium [GO:0097731]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasmic dynein complex [GO:0005868]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; microtubule [GO:0005874]; myosin V complex [GO:0031475]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	dynein intermediate chain binding [GO:0045505]	9+0 non-motile cilium [GO:0097731]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasmic dynein complex [GO:0005868]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; microtubule [GO:0005874]; myosin V complex [GO:0031475]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; dynein intermediate chain binding [GO:0045505]; microtubule-based process [GO:0007017]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20921139}.
Q96FL8	reviewed	S47A1_HUMAN	Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1)	SLC47A1 MATE1	Homo sapiens (Human)	570	FUNCTION: Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16330770, PubMed:17509534). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17495125, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:17582384, ECO:0000269|PubMed:18305230, ECO:0000269|PubMed:19158817, ECO:0000269|PubMed:21128598, ECO:0000269|PubMed:24961373, ECO:0000305|PubMed:35307651}.	MISCELLANEOUS: Mediates the efflux of cationic compounds such as the model cations, tetraethylammonium (TEA), the neurotoxin 1-methyl-4-phenylpyridinium (MPP), the platinum-based drugs cisplatin and oxaliplatin, the drugs procainamide, acyclovir and topotecan, or weak bases that are positively charged at physiological pH, such as cimetidine or the antidiabetic drug metformin. {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16914559, ECO:0000269|PubMed:17495125, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:17582384, ECO:0000269|PubMed:18305230, ECO:0000269|PubMed:19158817, ECO:0000269|PubMed:21128598, ECO:0000269|PubMed:26979622}.	amino acid import across plasma membrane [GO:0089718]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-arginine import across plasma membrane [GO:0097638]; organic cation transport [GO:0015695]; putrescine transport [GO:0015847]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	antiporter activity [GO:0015297]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; organic cation transmembrane transporter activity [GO:0015101]; polyspecific organic cation:proton antiporter activity [GO:0140968]; putrescine transmembrane transporter activity [GO:0015489]; thiamine transmembrane transporter activity [GO:0015234]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; organic cation transmembrane transporter activity [GO:0015101]; polyspecific organic cation:proton antiporter activity [GO:0140968]; putrescine transmembrane transporter activity [GO:0015489]; thiamine transmembrane transporter activity [GO:0015234]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]; amino acid import across plasma membrane [GO:0089718]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-arginine import across plasma membrane [GO:0097638]; organic cation transport [GO:0015695]; putrescine transport [GO:0015847]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16641166, ECO:0000269|PubMed:18305230, ECO:0000269|PubMed:19158817}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:16330770}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver). {ECO:0000269|PubMed:16330770}.
Q96FL9	reviewed	GLT14_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 14 (EC 2.4.1.41) (Polypeptide GalNAc transferase 14) (GalNAc-T14) (pp-GaNTase 14) (Protein-UDP acetylgalactosaminyltransferase 14) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14)	GALNT14 UNQ2434/PRO4994	Homo sapiens (Human)	552	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.	MISCELLANEOUS: [Isoform 1]: Major isoform.; MISCELLANEOUS: [Isoform 3]: Minor isoform. {ECO:0000305}.	O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q96FM1	reviewed	PGAP3_HUMAN	Post-GPI attachment to proteins factor 3 (COS16 homolog) (hCOS16) (Gene coamplified with ERBB2 protein) (PER1-like domain-containing protein 1)	PGAP3 CAB2 PERLD1 UNQ546/PRO1100	Homo sapiens (Human)	320	FUNCTION: Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. {ECO:0000269|PubMed:29374258, ECO:0000305|PubMed:17021251}.	MISCELLANEOUS: When transfected in S.cerevisiae, it can complement the absence of yeast of PER1 protein, suggesting a conserved role in lipid remodeling steps of GPI-anchor maturation.	GPI anchor biosynthetic process [GO:0006506]; GPI anchor metabolic process [GO:0006505]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	hydrolase activity, acting on ester bonds [GO:0016788]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; hydrolase activity, acting on ester bonds [GO:0016788]; GPI anchor biosynthetic process [GO:0006506]; GPI anchor metabolic process [GO:0006505]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:12460457}; Multi-pass membrane protein {ECO:0000305|PubMed:12460457}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:12460457}; Multi-pass membrane protein {ECO:0000305|PubMed:12460457}. Note=Mainly localizes to Golgi apparatus. {ECO:0000305}.
Q96FN4	reviewed	CPNE2_HUMAN	Copine-2 (Copine II)	CPNE2	Homo sapiens (Human)	548	FUNCTION: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties. {ECO:0000250|UniProtKB:P59108}.		cellular response to calcium ion [GO:0071277]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]; cellular response to calcium ion [GO:0071277]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P59108}. Nucleus {ECO:0000250|UniProtKB:P59108}. Cell membrane {ECO:0000250|UniProtKB:P59108}. Note=Translocates to the cell membrane and the nucleus in a calcium-dependent manner. Colocalizes with CD2 at the cell membrane. {ECO:0000250|UniProtKB:P59108}.
Q96FQ6	reviewed	S10AG_HUMAN	Protein S100-A16 (Aging-associated gene 13 protein) (Protein S100-F) (S100 calcium-binding protein A16)	S100A16 S100F AAG13	Homo sapiens (Human)	103	FUNCTION: Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity). {ECO:0000250|UniProtKB:Q9D708, ECO:0000269|PubMed:17030513}.		response to calcium ion [GO:0051592]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:17030513}. Cytoplasm {ECO:0000269|PubMed:17030513}. Note=Primarily nucleolar. A high intracellular calcium level induces nucleolar exit and nucleocytoplasmic transport, whereas a low intracellular calcium level leads to nuclear translocation and accumulation within specific region of nucleoli (PubMed:17030513).
Q96FS4	reviewed	SIPA1_HUMAN	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1)	SIPA1 SPA1	Homo sapiens (Human)	1042	FUNCTION: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}.		adaptive immune response [GO:0002250]; cellular response to water deprivation [GO:0042631]; cytoskeleton organization [GO:0007010]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell polarity [GO:0090162]; intracellular signal transduction [GO:0035556]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; GTPase activator activity [GO:0005096]; adaptive immune response [GO:0002250]; cellular response to water deprivation [GO:0042631]; cytoskeleton organization [GO:0007010]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell polarity [GO:0090162]; intracellular signal transduction [GO:0035556]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9346962}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9346962}. Endomembrane system; Peripheral membrane protein {ECO:0000269|PubMed:9346962}. Note=Mostly localized in the perinuclear membraneous region. {ECO:0000269|PubMed:9346962}.
Q96FT7	reviewed	ASIC4_HUMAN	Acid-sensing ion channel 4 (ASIC4) (Amiloride-sensitive cation channel 4) (Amiloride-sensitive cation channel 4, pituitary)	ASIC4 ACCN4	Homo sapiens (Human)	539	FUNCTION: Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. {ECO:0000269|PubMed:10852210}.		behavioral fear response [GO:0001662]; sodium ion transmembrane transport [GO:0035725]	plasma membrane [GO:0005886]	ligand-gated sodium channel activity [GO:0015280]; monoatomic ion channel activity [GO:0005216]; sodium ion transmembrane transporter activity [GO:0015081]	plasma membrane [GO:0005886]; ligand-gated sodium channel activity [GO:0015280]; monoatomic ion channel activity [GO:0005216]; sodium ion transmembrane transporter activity [GO:0015081]; behavioral fear response [GO:0001662]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q96FT9	reviewed	IFT43_HUMAN	Intraflagellar transport protein 43 homolog	IFT43 C14orf179	Homo sapiens (Human)	208	FUNCTION: As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis (PubMed:28400947, PubMed:28973684). Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base (PubMed:21378380). {ECO:0000269|PubMed:21378380, ECO:0000269|PubMed:28400947, ECO:0000269|PubMed:28973684}.		cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle A [GO:0030991]; microtubule cytoskeleton [GO:0015630]		centriolar satellite [GO:0034451]; centriole [GO:0005814]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle A [GO:0030991]; microtubule cytoskeleton [GO:0015630]; cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22361696}. Cell projection, cilium {ECO:0000269|PubMed:27932497, ECO:0000269|PubMed:28973684}. Note=Associated with microtubules (PubMed:22361696). Localized at the distal tip of the cilium (PubMed:28973684). {ECO:0000269|PubMed:22361696, ECO:0000269|PubMed:28973684}.
Q96FV9	reviewed	THOC1_HUMAN	THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84)	THOC1 HPR1	Homo sapiens (Human)	657	FUNCTION: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. May play a role in hair cell formation, hence may be involved in hearing (By similarity). {ECO:0000250|UniProtKB:Q7SYB2}.; FUNCTION: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	apoptotic process [GO:0006915]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; negative regulation of DNA damage checkpoint [GO:2000002]; negative regulation of isotype switching to IgA isotypes [GO:0048297]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; regulation of DNA recombination [GO:0000018]; regulation of DNA-templated transcription elongation [GO:0032784]; replication fork processing [GO:0031297]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; signal transduction [GO:0007165]; viral mRNA export from host cell nucleus [GO:0046784]	cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]	DNA binding [GO:0003677]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; negative regulation of DNA damage checkpoint [GO:2000002]; negative regulation of isotype switching to IgA isotypes [GO:0048297]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; regulation of DNA recombination [GO:0000018]; regulation of DNA-templated transcription elongation [GO:0032784]; replication fork processing [GO:0031297]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; signal transduction [GO:0007165]; viral mRNA export from host cell nucleus [GO:0046784]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Q96FW1	reviewed	OTUB1_HUMAN	Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)	OTUB1 OTB1 OTU1 HSPC263	Homo sapiens (Human)	271	FUNCTION: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation (PubMed:12704427, PubMed:14661020, PubMed:12401499, PubMed:23827681). Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen (PubMed:14661020). Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy (PubMed:14661020). Isoform 1 destabilizes RNF128, leading to prevent anergy (PubMed:14661020). In contrast, isoform 2 stabilizes RNF128 and promotes anergy (PubMed:14661020). Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128 (PubMed:14661020). Deubiquitinates estrogen receptor alpha (ESR1) (PubMed:19383985). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains (PubMed:19211026, PubMed:23827681, PubMed:18954305). Not able to cleave di-ubiquitin (PubMed:23827681, PubMed:18954305). Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (PubMed:23827681, PubMed:18954305). {ECO:0000269|PubMed:12401499, ECO:0000269|PubMed:12704427, ECO:0000269|PubMed:14661020, ECO:0000269|PubMed:18954305, ECO:0000269|PubMed:19211026, ECO:0000269|PubMed:19383985, ECO:0000269|PubMed:23827681}.; FUNCTION: Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites (PubMed:20725033, PubMed:22325355). Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of 'Lys-63'-linked histone H2A and H2AX marks (PubMed:20725033, PubMed:22325355). Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1 (PubMed:20725033, PubMed:22325355). The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved 'Lys48'-linked di-ubiquitin chain (PubMed:20725033, PubMed:22325355). Acts as a regulator of mTORC1 and mTORC2 complexes (PubMed:29382726, PubMed:35927303). When phosphorylated at Tyr-26, acts as an activator of the mTORC1 complex by mediating deubiquitination of RPTOR via a non-catalytic process: acts by binding and inhibiting the activity of the ubiquitin-conjugating enzyme E2 (UBE2D1/UBCH5A, UBE2W/UBC16 and UBE2N/UBC13), thereby preventing ubiquitination of RPTOR (PubMed:35927303). Can also act as an inhibitor of the mTORC1 and mTORC2 complexes in response to amino acids by mediating non-catalytic deubiquitination of DEPTOR (PubMed:29382726). {ECO:0000269|PubMed:20725033, ECO:0000269|PubMed:22325355, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:35927303}.	MISCELLANEOUS: In the structure described by PubMed:18954305, the His-265 active site of the catalytic triad is located too far to interact directly with the active site Cys-91 (PubMed:18954305). A possible explanation is that OTUB1 is in inactive conformation in absence of ubiquitin and a conformation change may move His-265 in the proximity of Cys-91 in presence of ubiquitin substrate (PubMed:18954305). {ECO:0000269|PubMed:18954305}.; MISCELLANEOUS: [Isoform 2]: Lacks the catalytic sites for protease activity. {ECO:0000305}.	adaptive immune response [GO:0002250]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair [GO:2000780]; positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	cysteine-type deubiquitinase activity [GO:0004843]; deNEDDylase activity [GO:0019784]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase inhibitor activity [GO:0055105]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; cysteine-type deubiquitinase activity [GO:0004843]; deNEDDylase activity [GO:0019784]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase inhibitor activity [GO:0055105]; adaptive immune response [GO:0002250]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair [GO:2000780]; positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B2RYG6}.
Q96FX2	reviewed	DPH3_HUMAN	Diphthamide biosynthesis protein 3 (CSL-type zinc finger-containing protein 2) (DelGEF-interacting protein 1) (DelGIP1)	DPH3 DESR1 ZCSL2	Homo sapiens (Human)	82	FUNCTION: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). {ECO:0000250|UniProtKB:Q3E840}.		negative regulation of protein secretion [GO:0050709]; positive regulation of binding [GO:0051099]; protein histidyl modification to diphthamide [GO:0017183]; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ferrous iron binding [GO:0008198]; iron chaperone activity [GO:0034986]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ferrous iron binding [GO:0008198]; iron chaperone activity [GO:0034986]; negative regulation of protein secretion [GO:0050709]; positive regulation of binding [GO:0051099]; protein histidyl modification to diphthamide [GO:0017183]; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14980502}. Nucleus {ECO:0000269|PubMed:14980502}.
Q96FX7	reviewed	TRM61_HUMAN	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A)	TRMT61A C14orf172 TRM61	Homo sapiens (Human)	289	FUNCTION: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297). {ECO:0000269|PubMed:16043508, ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537}.		mRNA methylation [GO:0080009]; tRNA methylation [GO:0030488]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515]	mRNA (adenine-N1-)-methyltransferase activity [GO:0061953]; tRNA (adenine-N1-)-methyltransferase activity [GO:0016429]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515]; mRNA (adenine-N1-)-methyltransferase activity [GO:0061953]; tRNA (adenine-N1-)-methyltransferase activity [GO:0016429]; mRNA methylation [GO:0080009]; tRNA methylation [GO:0030488]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P46959}.
Q96FX8	reviewed	PERP_HUMAN	p53 apoptosis effector related to PMP-22 (Keratinocyte-associated protein 1) (KCP-1) (P53-induced protein PIGPC1) (Transmembrane protein THW)	PERP KCP1 KRTCAP1 PIGPC1 THW	Homo sapiens (Human)	193	FUNCTION: Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. {ECO:0000250|UniProtKB:Q9JK95}.; FUNCTION: Plays a role as an effector in the TP53-dependent apoptotic pathway. {ECO:0000250|UniProtKB:Q9JK95}.		activation of cysteine-type endopeptidase activity [GO:0097202]; amelogenesis [GO:0097186]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; heterotypic cell-cell adhesion [GO:0034113]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; Notch signaling pathway [GO:0007219]; positive regulation of proteolysis [GO:0045862]	cell-cell junction [GO:0005911]; desmosome [GO:0030057]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]		cell-cell junction [GO:0005911]; desmosome [GO:0030057]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; activation of cysteine-type endopeptidase activity [GO:0097202]; amelogenesis [GO:0097186]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; heterotypic cell-cell adhesion [GO:0034113]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; Notch signaling pathway [GO:0007219]; positive regulation of proteolysis [GO:0045862]	SUBCELLULAR LOCATION: Cell junction, desmosome {ECO:0000250|UniProtKB:Q9JK95}. Cell membrane {ECO:0000269|PubMed:30321533, ECO:0000269|PubMed:31898316}; Multi-pass membrane protein {ECO:0000255}. Note=Associated with desmosomes (By similarity). Colocalizes with KRT14 in the cell membrane (PubMed:31898316). {ECO:0000250|UniProtKB:Q9JK95, ECO:0000269|PubMed:31898316}.
Q96FZ2	reviewed	HMCES_HUMAN	Abasic site processing protein HMCES (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1)	HMCES C3orf37 DC12 SRAPD1	Homo sapiens (Human)	354	FUNCTION: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235915, PubMed:31235913). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913). The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). {ECO:0000250|UniProtKB:Q8R1M0, ECO:0000269|PubMed:30554877, ECO:0000269|PubMed:31235913, ECO:0000269|PubMed:31235915, ECO:0000269|PubMed:31806351}.		DNA damage response [GO:0006974]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; positive regulation of isotype switching [GO:0045830]; protein-DNA covalent cross-linking [GO:0018142]; proteolysis [GO:0006508]	replication fork [GO:0005657]	peptidase activity [GO:0008233]; single-stranded DNA binding [GO:0003697]	replication fork [GO:0005657]; peptidase activity [GO:0008233]; single-stranded DNA binding [GO:0003697]; DNA damage response [GO:0006974]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; positive regulation of isotype switching [GO:0045830]; protein-DNA covalent cross-linking [GO:0018142]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:30554877}. Note=Recruited to chromatin following DNA damage (PubMed:30554877). Localizes to replication forks (PubMed:30554877). {ECO:0000269|PubMed:30554877}.
Q96FZ5	reviewed	CKLF7_HUMAN	CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7)	CMTM7 CKLFSF7	Homo sapiens (Human)	175			B-1a B cell differentiation [GO:0002337]; chemotaxis [GO:0006935]	extracellular space [GO:0005615]; membrane [GO:0016020]	cytokine activity [GO:0005125]	extracellular space [GO:0005615]; membrane [GO:0016020]; cytokine activity [GO:0005125]; B-1a B cell differentiation [GO:0002337]; chemotaxis [GO:0006935]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q96FZ7	reviewed	CHMP6_HUMAN	Charged multivesicular body protein 6 (Chromatin-modifying protein 6) (Vacuolar protein sorting-associated protein 20) (Vps20) (hVps20)	CHMP6 VPS20	Homo sapiens (Human)	201	FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.		autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; ESCRT III complex assembly [GO:1904902]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]	protein-containing complex binding [GO:0044877]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]; protein-containing complex binding [GO:0044877]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; ESCRT III complex assembly [GO:1904902]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane {ECO:0000305}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Localizes to endosomal membranes.
Q96G01	reviewed	BICD1_HUMAN	Protein bicaudal D homolog 1 (Bic-D 1)	BICD1	Homo sapiens (Human)	975	FUNCTION: Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.	MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Due to intron retention. {ECO:0000305}.	anatomical structure morphogenesis [GO:0009653]; intracellular mRNA localization [GO:0008298]; microtubule anchoring at microtubule organizing center [GO:0072393]; minus-end-directed organelle transport along microtubule [GO:0072385]; negative regulation of phospholipase C activity [GO:1900275]; negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900737]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein localization to organelle [GO:0033365]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of proteinase activated receptor activity [GO:1900276]; RNA processing [GO:0006396]; stress granule assembly [GO:0034063]; viral process [GO:0016032]	centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; secretory vesicle [GO:0099503]; trans-Golgi network [GO:0005802]	cytoskeletal anchor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein intermediate chain binding [GO:0045505]; protein kinase binding [GO:0019901]; proteinase activated receptor binding [GO:0031871]; small GTPase binding [GO:0031267]; structural constituent of cytoskeleton [GO:0005200]	centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; secretory vesicle [GO:0099503]; trans-Golgi network [GO:0005802]; cytoskeletal anchor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein intermediate chain binding [GO:0045505]; protein kinase binding [GO:0019901]; proteinase activated receptor binding [GO:0031871]; small GTPase binding [GO:0031267]; structural constituent of cytoskeleton [GO:0005200]; anatomical structure morphogenesis [GO:0009653]; intracellular mRNA localization [GO:0008298]; microtubule anchoring at microtubule organizing center [GO:0072393]; minus-end-directed organelle transport along microtubule [GO:0072385]; negative regulation of phospholipase C activity [GO:1900275]; negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900737]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein localization to organelle [GO:0033365]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of proteinase activated receptor activity [GO:1900276]; RNA processing [GO:0006396]; stress granule assembly [GO:0034063]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Golgi apparatus.
Q96G03	reviewed	PGM2_HUMAN	Phosphopentomutase (EC 5.4.2.7) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphoglucomutase-2) (EC 5.4.2.2)	PGM2 MSTP006	Homo sapiens (Human)	612	FUNCTION: Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. Catalyzes the interconversion of glucose-1-phosphate into glucose-6-phosphate but with a lower catalytic efficiency (PubMed:17804405). In vitro, has also a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant (PubMed:17804405, PubMed:18927083). {ECO:0000269|PubMed:17804405, ECO:0000269|PubMed:18927083}.		glucose metabolic process [GO:0006006]; glycogen catabolic process [GO:0005980]; purine ribonucleoside salvage [GO:0006166]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]	magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]; phosphopentomutase activity [GO:0008973]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]; phosphopentomutase activity [GO:0008973]; glucose metabolic process [GO:0006006]; glycogen catabolic process [GO:0005980]; purine ribonucleoside salvage [GO:0006166]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17804405}.
Q96G04	reviewed	EF2KT_HUMAN	Protein-lysine N-methyltransferase EEF2KMT (EC 2.1.1.-) (eEF2-lysine methyltransferase) (eEF2-KMT)	EEF2KMT FAM86A SB153	Homo sapiens (Human)	330	FUNCTION: Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'. {ECO:0000269|PubMed:25231979}.		peptidyl-lysine trimethylation [GO:0018023]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]	histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279]; peptidyl-lysine trimethylation [GO:0018023]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23349634}.
Q96G21	reviewed	IMP4_HUMAN	U3 small nucleolar ribonucleoprotein protein IMP4 (U3 snoRNP protein IMP4) (Brix domain-containing protein 4)	IMP4 BXDC4	Homo sapiens (Human)	291	FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}.		maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	fibrillar center [GO:0001650]; Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome [GO:0030684]; small-subunit processome [GO:0032040]	rRNA primary transcript binding [GO:0042134]; snoRNA binding [GO:0030515]	fibrillar center [GO:0001650]; Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome [GO:0030684]; small-subunit processome [GO:0032040]; rRNA primary transcript binding [GO:0042134]; snoRNA binding [GO:0030515]; maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:16533400, ECO:0000269|PubMed:34516797}.
Q96G23	reviewed	CERS2_HUMAN	Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Sphingosine N-acyltransferase CERS2) (EC 2.3.1.24) (Tumor metastasis-suppressor gene 1 protein) (Very-long-chain ceramide synthase CERS2) (EC 2.3.1.297)	CERS2 LASS2 TMSG1	Homo sapiens (Human)	380	FUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:19728861, PubMed:20937905, PubMed:22144673, PubMed:22661289, PubMed:26887952, PubMed:29632068). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (By similarity) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:19728861, PubMed:20937905, PubMed:22144673, PubMed:22661289, PubMed:26887952, PubMed:29632068). Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions (By similarity). {ECO:0000250|UniProtKB:Q924Z4, ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:18165233, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:19728861, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:22144673, ECO:0000269|PubMed:22661289, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068}.		ceramide biosynthetic process [GO:0046513]; negative regulation of axon regeneration [GO:0048681]; negative regulation of Schwann cell migration [GO:1900148]; negative regulation of Schwann cell proliferation involved in axon regeneration [GO:1905045]; regulation of lipid metabolic process [GO:0019216]; response to immobilization stress [GO:0035902]; sphingolipid biosynthetic process [GO:0030148]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291]; ceramide biosynthetic process [GO:0046513]; negative regulation of axon regeneration [GO:0048681]; negative regulation of Schwann cell migration [GO:1900148]; negative regulation of Schwann cell proliferation involved in axon regeneration [GO:1905045]; regulation of lipid metabolic process [GO:0019216]; response to immobilization stress [GO:0035902]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18165233}; Multi-pass membrane protein {ECO:0000255}.
Q96G25	reviewed	MED8_HUMAN	Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)	MED8	Homo sapiens (Human)	268	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.		positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96G28	reviewed	CFA36_HUMAN	Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104)	CFAP36 CCDC104 UNQ163/PRO189	Homo sapiens (Human)	342	FUNCTION: May act as an effector for ARL3.			axoneme [GO:0005930]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; motile cilium [GO:0031514]; nucleus [GO:0005634]		axoneme [GO:0005930]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; motile cilium [GO:0031514]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000303|PubMed:19680650}. Cytoplasm {ECO:0000303|PubMed:19680650}. Cell projection, cilium, flagellum {ECO:0000305}.
Q96G30	reviewed	MRAP2_HUMAN	Melanocortin-2 receptor accessory protein 2 (MC2R accessory protein 2)	MRAP2 C6orf117	Homo sapiens (Human)	205	FUNCTION: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo. {ECO:0000250, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.		energy homeostasis [GO:0097009]; energy reserve metabolic process [GO:0006112]; feeding behavior [GO:0007631]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; protein localization to plasma membrane [GO:0072659]; regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106070]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	corticotropin hormone receptor binding [GO:0031780]; identical protein binding [GO:0042802]; signaling receptor regulator activity [GO:0030545]; type 1 melanocortin receptor binding [GO:0070996]; type 3 melanocortin receptor binding [GO:0031781]; type 4 melanocortin receptor binding [GO:0031782]; type 5 melanocortin receptor binding [GO:0031783]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; corticotropin hormone receptor binding [GO:0031780]; identical protein binding [GO:0042802]; signaling receptor regulator activity [GO:0030545]; type 1 melanocortin receptor binding [GO:0070996]; type 3 melanocortin receptor binding [GO:0031781]; type 4 melanocortin receptor binding [GO:0031782]; type 5 melanocortin receptor binding [GO:0031783]; energy homeostasis [GO:0097009]; energy reserve metabolic process [GO:0006112]; feeding behavior [GO:0007631]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; protein localization to plasma membrane [GO:0072659]; regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106070]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19329486}; Single-pass membrane protein {ECO:0000269|PubMed:19329486}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19329486}; Single-pass membrane protein {ECO:0000269|PubMed:19329486}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. {ECO:0000269|PubMed:20371771}.
Q96G42	reviewed	KLD7B_HUMAN	Kelch domain-containing protein 7B	KLHDC7B	Homo sapiens (Human)	594							
Q96G46	reviewed	DUS3L_HUMAN	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.89) (mRNA-dihydrouridine synthase DUS3L) (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like)	DUS3L	Homo sapiens (Human)	650	FUNCTION: Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:34556860). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs (PubMed:34556860). Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation (PubMed:34556860). {ECO:0000269|PubMed:34556860}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mRNA processing [GO:0006397]; regulation of translation [GO:0006417]; tRNA dihydrouridine synthesis [GO:0002943]		flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; mRNA dihydrouridine synthase activity [GO:0106414]; RNA binding [GO:0003723]; tRNA dihydrouridine synthase activity [GO:0017150]	flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; mRNA dihydrouridine synthase activity [GO:0106414]; RNA binding [GO:0003723]; tRNA dihydrouridine synthase activity [GO:0017150]; mRNA processing [GO:0006397]; regulation of translation [GO:0006417]; tRNA dihydrouridine synthesis [GO:0002943]	
Q96G61	reviewed	NUD11_HUMAN	Diphosphoinositol polyphosphate phosphohydrolase 3-beta (DIPP-3-beta) (DIPP3-beta) (hDIPP3beta) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta) (Diadenosine hexaphosphate hydrolase (AMP-forming)) (EC 3.6.1.60) (Nucleoside diphosphate-linked moiety X motif 11) (Nudix motif 11) (hAps1)	NUDT11 APS1 DIPP3B	Homo sapiens (Human)	164	FUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. {ECO:0000269|PubMed:12105228}.		adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; metal ion binding [GO:0046872]; adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12121577}.
Q96G74	reviewed	OTUD5_HUMAN	OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)	OTUD5	Homo sapiens (Human)	571	FUNCTION: Deubiquitinating enzyme that functions as negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:33523931}.	MISCELLANEOUS: [Isoform 2]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.	negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of type I interferon production [GO:0032480]; neural crest cell differentiation [GO:0014033]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; response to lipopolysaccharide [GO:0032496]	cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]	cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of type I interferon production [GO:0032480]; neural crest cell differentiation [GO:0014033]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33523931}.
Q96G75	reviewed	RMD5B_HUMAN	E3 ubiquitin-protein transferase RMND5B (EC 2.3.2.27) (Protein RMD5 homolog B)	RMND5B UNQ2508/PRO5996	Homo sapiens (Human)	393	FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). {ECO:0000269|PubMed:29911972}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GID complex [GO:0034657]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GID complex [GO:0034657]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25793641}.
Q96G79	reviewed	S35A4_HUMAN	Probable UDP-sugar transporter protein SLC35A4 (Solute carrier family 35 member A4)	SLC35A4	Homo sapiens (Human)	324	FUNCTION: Mediates the transport of CDP-ribitol (PubMed:34015330). Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity (PubMed:28167211, PubMed:34015330). {ECO:0000269|PubMed:28167211, ECO:0000269|PubMed:34015330}.		carbohydrate transport [GO:0008643]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165]; carbohydrate transport [GO:0008643]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:28167211}; Multi-pass membrane protein {ECO:0000255}.
Q96G91	reviewed	P2Y11_HUMAN	P2Y purinoceptor 11 (P2Y11)	P2RY11	Homo sapiens (Human)	374	FUNCTION: Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.	MISCELLANEOUS: A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528). {ECO:0000305|PubMed:11278528}.	activation of adenylate cyclase activity [GO:0007190]; calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; defense response [GO:0006952]; G protein-coupled receptor signaling pathway [GO:0007186]; neuronal signal transduction [GO:0023041]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	plasma membrane [GO:0005886]	G protein-coupled ATP receptor activity [GO:0045031]; neurotransmitter receptor activity [GO:0030594]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; G protein-coupled ATP receptor activity [GO:0045031]; neurotransmitter receptor activity [GO:0030594]; signaling receptor activity [GO:0038023]; activation of adenylate cyclase activity [GO:0007190]; calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; defense response [GO:0006952]; G protein-coupled receptor signaling pathway [GO:0007186]; neuronal signal transduction [GO:0023041]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96G97	reviewed	BSCL2_HUMAN	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein)	BSCL2	Homo sapiens (Human)	398	FUNCTION: Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:19278620, PubMed:21533227, PubMed:31708432, PubMed:30293840). In association with LDAF1, defines the sites of LD formation in the ER (PubMed:31708432). Also required for growth and maturation of small nascent LDs into larger mature LDs (PubMed:27564575). Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs (PubMed:31178403, PubMed:27879284). Regulates the maturation of ZFYVE1-positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts (PubMed:30970241). Binds anionic phospholipids including phosphatidic acid (PubMed:30293840). Plays an important role in the differentiation and development of adipocytes (By similarity). {ECO:0000250|UniProtKB:Q9Z2E9, ECO:0000269|PubMed:19278620, ECO:0000269|PubMed:21533227, ECO:0000269|PubMed:27564575, ECO:0000269|PubMed:27879284, ECO:0000269|PubMed:30293840, ECO:0000269|PubMed:30970241, ECO:0000269|PubMed:31178403, ECO:0000269|PubMed:31708432}.		fat cell differentiation [GO:0045444]; lipid catabolic process [GO:0016042]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; negative regulation of lipid catabolic process [GO:0050995]; positive regulation of cold-induced thermogenesis [GO:0120162]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]	phospholipid binding [GO:0005543]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; phospholipid binding [GO:0005543]; fat cell differentiation [GO:0045444]; lipid catabolic process [GO:0016042]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; negative regulation of lipid catabolic process [GO:0050995]; positive regulation of cold-induced thermogenesis [GO:0120162]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14981520, ECO:0000269|PubMed:16574104, ECO:0000269|PubMed:18458148, ECO:0000269|PubMed:27879284, ECO:0000269|PubMed:30901948, ECO:0000269|PubMed:31708432}; Multi-pass membrane protein {ECO:0000255}. Lipid droplet {ECO:0000269|PubMed:27879284, ECO:0000269|PubMed:30970241}. Note=Localizes at endoplasmic reticulum-lipid droplets (ER-LD) contact sites. {ECO:0000269|PubMed:27879284}.
Q96GA7	reviewed	SDSL_HUMAN	Serine dehydratase-like (L-serine deaminase) (L-serine dehydratase/L-threonine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) (Serine dehydratase 2) (SDH 2) (EC 4.3.1.17)	SDSL	Homo sapiens (Human)	329	FUNCTION: Has low serine dehydratase and threonine dehydratase activity.		isoleucine biosynthetic process [GO:0009097]; L-serine catabolic process [GO:0006565]; lipid metabolic process [GO:0006629]; threonine catabolic process [GO:0006567]	cytosol [GO:0005829]	identical protein binding [GO:0042802]; L-serine ammonia-lyase activity [GO:0003941]; L-threonine ammonia-lyase activity [GO:0004794]; pyridoxal phosphate binding [GO:0030170]	cytosol [GO:0005829]; identical protein binding [GO:0042802]; L-serine ammonia-lyase activity [GO:0003941]; L-threonine ammonia-lyase activity [GO:0004794]; pyridoxal phosphate binding [GO:0030170]; isoleucine biosynthetic process [GO:0009097]; L-serine catabolic process [GO:0006565]; lipid metabolic process [GO:0006629]; threonine catabolic process [GO:0006567]	
Q96GC6	reviewed	ZN274_HUMAN	Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) (Zinc finger protein HFB101) (Zinc finger protein with KRAB and SCAN domains 19) (Zinc finger protein zfp2) (Zf2)	ZNF274 ZKSCAN19 SP2114	Homo sapiens (Human)	653	FUNCTION: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000269|PubMed:10777669, ECO:0000269|PubMed:27029610}.		chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000269|PubMed:10777669}.
Q96GC9	reviewed	VMP1_HUMAN	Vacuole membrane protein 1 (Transmembrane protein 49)	VMP1 TDC1 TMEM49 HSPC292	Homo sapiens (Human)	406	FUNCTION: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (PubMed:33929485, PubMed:33850023). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (PubMed:33929485, PubMed:33850023). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:28890335, PubMed:30093494, PubMed:30933966, PubMed:33929485, PubMed:33850023). Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:31526472, PubMed:33850023). Modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). Plays an essential role in formation of cell junctions (PubMed:17724469). Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death (By similarity). Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity). {ECO:0000250|UniProtKB:Q91ZQ0, ECO:0000269|PubMed:17724469, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:30093494, ECO:0000269|PubMed:30933966, ECO:0000269|PubMed:31526472, ECO:0000269|PubMed:33850023, ECO:0000269|PubMed:33929485}.; FUNCTION: (Microbial infection) Host factor required for infection by all flaviviruses tested such as Zika virus and Yellow fever virus (PubMed:33338421). Probably required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles (PubMed:33338421). {ECO:0000269|PubMed:33338421}.		autophagosome assembly [GO:0000045]; autophagosome membrane docking [GO:0016240]; autophagy [GO:0006914]; cell junction assembly [GO:0034329]; cell-cell adhesion [GO:0098609]; embryo implantation [GO:0007566]; Golgi organization [GO:0007030]; lipoprotein transport [GO:0042953]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; organelle localization by membrane tethering [GO:0140056]; positive regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901896]	autophagosome membrane [GO:0000421]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; nucleolus [GO:0005730]; phagophore assembly site [GO:0000407]; plasma membrane [GO:0005886]	phospholipid scramblase activity [GO:0017128]	autophagosome membrane [GO:0000421]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; nucleolus [GO:0005730]; phagophore assembly site [GO:0000407]; plasma membrane [GO:0005886]; phospholipid scramblase activity [GO:0017128]; autophagosome assembly [GO:0000045]; autophagosome membrane docking [GO:0016240]; autophagy [GO:0006914]; cell junction assembly [GO:0034329]; cell-cell adhesion [GO:0098609]; embryo implantation [GO:0007566]; Golgi organization [GO:0007030]; lipoprotein transport [GO:0042953]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; organelle localization by membrane tethering [GO:0140056]; positive regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901896]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q91ZQ0}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:17724469}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:Q91ZQ0}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17724469, ECO:0000269|PubMed:28890335}; Multi-pass membrane protein {ECO:0000255}.
Q96GD0	reviewed	PLPP_HUMAN	Chronophin (EC 3.1.3.16) (EC 3.1.3.74) (Pyridoxal phosphate phosphatase) (PLP phosphatase)	PDXP CIN PLP PLPP	Homo sapiens (Human)	296	FUNCTION: Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism (PubMed:14522954, PubMed:8132548). Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine (PubMed:15580268). {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:8132548}.		actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; dephosphorylation [GO:0016311]; positive regulation of actin filament depolymerization [GO:0030836]; protein dephosphorylation [GO:0006470]; pyridoxal phosphate catabolic process [GO:0032361]; regulation of cytokinesis [GO:0032465]; regulation of mitotic nuclear division [GO:0007088]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; lamellipodium membrane [GO:0031258]; ruffle membrane [GO:0032587]	heat shock protein binding [GO:0031072]; magnesium ion binding [GO:0000287]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein homodimerization activity [GO:0042803]; pyridoxal phosphatase activity [GO:0033883]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; lamellipodium membrane [GO:0031258]; ruffle membrane [GO:0032587]; heat shock protein binding [GO:0031072]; magnesium ion binding [GO:0000287]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein homodimerization activity [GO:0042803]; pyridoxal phosphatase activity [GO:0033883]; actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; dephosphorylation [GO:0016311]; positive regulation of actin filament depolymerization [GO:0030836]; protein dephosphorylation [GO:0006470]; pyridoxal phosphate catabolic process [GO:0032361]; regulation of cytokinesis [GO:0032465]; regulation of mitotic nuclear division [GO:0007088]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody. {ECO:0000269|PubMed:15580268}.
Q96GD3	reviewed	SCMH1_HUMAN	Polycomb protein SCMH1 (Sex comb on midleg homolog 1)	SCMH1	Homo sapiens (Human)	660	FUNCTION: Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes. {ECO:0000250}.	MISCELLANEOUS: [Isoform 5]: May be due to intron retention. {ECO:0000303|PubMed:10524249}.	heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96GD4	reviewed	AURKB_HUMAN	Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	Homo sapiens (Human)	344	FUNCTION: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11784863, PubMed:12689593, PubMed:14602875, PubMed:11856369, PubMed:16103226, PubMed:21658950, PubMed:11756469). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}.		abscission [GO:0009838]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell cycle G2/M phase transition [GO:0044839]; cellular response to UV [GO:0034644]; cleavage furrow formation [GO:0036089]; histone modification [GO:0016570]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cytokinesis [GO:0032466]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of cytokinesis [GO:0032467]; positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore [GO:1905116]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; post-translational protein modification [GO:0043687]; protein autophosphorylation [GO:0046777]; protein localization to kinetochore [GO:0034501]; protein phosphorylation [GO:0006468]; regulation of chromosome segregation [GO:0051983]; regulation of cytokinesis [GO:0032465]; regulation of signal transduction by p53 class mediator [GO:1901796]; spindle organization [GO:0007051]	chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]; spindle pole centrosome [GO:0031616]	ATP binding [GO:0005524]; kinase binding [GO:0019900]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]	chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]; spindle pole centrosome [GO:0031616]; ATP binding [GO:0005524]; kinase binding [GO:0019900]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; abscission [GO:0009838]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell cycle G2/M phase transition [GO:0044839]; cellular response to UV [GO:0034644]; cleavage furrow formation [GO:0036089]; histone modification [GO:0016570]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cytokinesis [GO:0032466]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of cytokinesis [GO:0032467]; positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore [GO:1905116]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; post-translational protein modification [GO:0043687]; protein autophosphorylation [GO:0046777]; protein localization to kinetochore [GO:0034501]; protein phosphorylation [GO:0006468]; regulation of chromosome segregation [GO:0051983]; regulation of cytokinesis [GO:0032465]; regulation of signal transduction by p53 class mediator [GO:1901796]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20959462}. Chromosome {ECO:0000269|PubMed:20929775}. Chromosome, centromere {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:20929775}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:26829474}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:20605920}. Midbody {ECO:0000269|PubMed:16179162, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:23036704}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:20929775). Colocalized with gamma tubulin in the midbody (PubMed:17726514). Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC (PubMed:20605920). Colocalized with SIRT2 during cytokinesis with the midbody (PubMed:17726514). Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12 (PubMed:20929775). {ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:20605920, ECO:0000269|PubMed:20929775}.
Q96GE4	reviewed	CEP95_HUMAN	Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45)	CEP95 CCDC45 CEP45	Homo sapiens (Human)	821				centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle pole [GO:0000922]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle pole [GO:0000922]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:21399614}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:21399614}.
Q96GF1	reviewed	RN185_HUMAN	E3 ubiquitin-protein ligase RNF185 (EC 2.3.2.27) (RING finger protein 185)	RNF185	Homo sapiens (Human)	192	FUNCTION: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693). Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036). Protects cells from ER stress-induced apoptosis (PubMed:27485036). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521). Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS at 'Lys-173' and 'Lys-384', thereby promoting CGAS cyclic GMP-AMP synthase activity (PubMed:28273161). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521). {ECO:0000269|PubMed:21931693, ECO:0000269|PubMed:24019521, ECO:0000269|PubMed:27485036, ECO:0000269|PubMed:28273161}.		autophagy [GO:0006914]; defense response to virus [GO:0051607]; ER-associated misfolded protein catabolic process [GO:0071712]; ERAD pathway [GO:0036503]; innate immune response [GO:0045087]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of innate immune response [GO:0045089]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein autoubiquitination [GO:0051865]; protein K27-linked ubiquitination [GO:0044314]; transmembrane transport [GO:0055085]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]	metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; autophagy [GO:0006914]; defense response to virus [GO:0051607]; ER-associated misfolded protein catabolic process [GO:0071712]; ERAD pathway [GO:0036503]; innate immune response [GO:0045087]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of innate immune response [GO:0045089]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein autoubiquitination [GO:0051865]; protein K27-linked ubiquitination [GO:0044314]; transmembrane transport [GO:0055085]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:21931693}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24019521, ECO:0000269|PubMed:27485036}; Multi-pass membrane protein {ECO:0000255}.
Q96GG9	reviewed	DCNL1_HUMAN	DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)	DCUN1D1 DCN1 DCUN1L1 RP42 SCCRO	Homo sapiens (Human)	259	FUNCTION: Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:26906416, PubMed:23201271, PubMed:19617556, PubMed:23401859). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). {ECO:0000250|UniProtKB:Q9QZ73, ECO:0000269|PubMed:18826954, ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:23401859, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416, ECO:0000269|PubMed:28581483}.		positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]; regulation of protein ubiquitination [GO:0031396]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182]; positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]; regulation of protein ubiquitination [GO:0031396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416}. Cytoplasm {ECO:0000269|PubMed:26906416}. Note=The ubiquitinated form is localized in the cytoplasm. {ECO:0000269|PubMed:30587576}.
Q96GJ1	reviewed	TRM2B_HUMAN	tRNA (uracil-5-)-methyltransferase homolog B (EC 2.1.1.35) (TRM2 homolog B) (rRNA (uracil-5-)-methyltransferase TRMT2B) (EC 2.1.1.-)	TRMT2B CXorf34	Homo sapiens (Human)	504	FUNCTION: Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA (PubMed:31948311, PubMed:34556860). Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs (PubMed:31948311). Specifically methylates the uridine in position 429 of 12S rRNA (m5U429) (PubMed:31948311). Does not affect RNA stability or mitochondrial translation (PubMed:31948311). {ECO:0000269|PubMed:31948311, ECO:0000269|PubMed:34556860}.			mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	rRNA (uridine-C5-)-methyltransferase activity [GO:0070041]; S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity [GO:0030697]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; rRNA (uridine-C5-)-methyltransferase activity [GO:0070041]; S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity [GO:0030697]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:31948311}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion matrix {ECO:0000269|PubMed:27184847}.
Q96GL9	reviewed	F163A_HUMAN	Protein FAM163A (Cebelin) (Neuroblastoma-derived secretory protein)	FAM163A C1orf76 NDSP	Homo sapiens (Human)	167				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96GM1	reviewed	PLPR2_HUMAN	Phospholipid phosphatase-related protein type 2 (Inactive phospholipid phosphatase PLPPR2) (Lipid phosphate phosphatase-related protein type 2) (Plasticity-related gene 4 protein) (PRG-4)	PLPPR2 LPPR2 PRG4	Homo sapiens (Human)	343			phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165]	membrane [GO:0016020]	phosphatidate phosphatase activity [GO:0008195]	membrane [GO:0016020]; phosphatidate phosphatase activity [GO:0008195]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q96GM5	reviewed	SMRD1_HUMAN	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (SWI/SNF complex 60 kDa subunit)	SMARCD1 BAF60A	Homo sapiens (Human)	515	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342). Interacts with AKIRIN2 (By similarity). {ECO:0000250|UniProtKB:Q61466, ECO:0000269|PubMed:12917342, ECO:0000269|PubMed:14698202, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:8804307, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.		cellular response to fatty acid [GO:0071398]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]	brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; cellular response to fatty acid [GO:0071398]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8804307, ECO:0000305}.
Q96GM8	reviewed	TOE1_HUMAN	Target of EGR1 protein 1	TOE1	Homo sapiens (Human)	510	FUNCTION: Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684). {ECO:0000269|PubMed:12562764, ECO:0000269|PubMed:28092684}.		snRNA 3'-end processing [GO:0034472]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; snRNA binding [GO:0017069]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; snRNA binding [GO:0017069]; snRNA 3'-end processing [GO:0034472]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12562764}. Nucleus speckle {ECO:0000269|PubMed:12562764}. Note=Localizes to nuclear speckles.
Q96GN5	reviewed	CDA7L_HUMAN	Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2)	CDCA7L HR1 JPO2 R1	Homo sapiens (Human)	454	FUNCTION: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000269|PubMed:15654081, ECO:0000269|PubMed:15994933, ECO:0000269|PubMed:16829576}.	MISCELLANEOUS: Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.	positive regulation of cell population proliferation [GO:0008284]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; positive regulation of cell population proliferation [GO:0008284]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
Q96GP6	reviewed	SREC2_HUMAN	Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II)	SCARF2 SREC2 SREPCR	Homo sapiens (Human)	871	FUNCTION: Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity). {ECO:0000250}.		heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]	focal adhesion [GO:0005925]; membrane [GO:0016020]	scavenger receptor activity [GO:0005044]	focal adhesion [GO:0005925]; membrane [GO:0016020]; scavenger receptor activity [GO:0005044]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q96GQ5	reviewed	RUSF1_HUMAN	RUS family member 1	RUSF1 C16orf58	Homo sapiens (Human)	468				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96GQ7	reviewed	DDX27_HUMAN	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.4.13) (DEAD box protein 27)	DDX27 cPERP-F RHLP HSPC259 PP3241	Homo sapiens (Human)	796	FUNCTION: Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154). {ECO:0000269|PubMed:25825154}.		rRNA processing [GO:0006364]	chromosome [GO:0005694]; nucleolus [GO:0005730]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	chromosome [GO:0005694]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:25825154}. Chromosome {ECO:0000269|PubMed:20813266}. Note=Associates with 60S and 90S pre-ribosomal particles (PubMed:25825154). {ECO:0000269|PubMed:25825154}.
Q96GR2	reviewed	ACBG1_HUMAN	Long-chain-fatty-acid--CoA ligase ACSBG1 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 1) (hBG1) (hsBG) (hsBGM) (Lipidosin)	ACSBG1 BGM KIAA0631 LPD	Homo sapiens (Human)	724	FUNCTION: Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:12975357, PubMed:24269233, PubMed:10954726). Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:10954726). {ECO:0000269|PubMed:10954726, ECO:0000269|PubMed:12975357, ECO:0000269|PubMed:24269233}.		long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; myelination [GO:0042552]; response to glucocorticoid [GO:0051384]; very long-chain fatty acid metabolic process [GO:0000038]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; myelination [GO:0042552]; response to glucocorticoid [GO:0051384]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10954726}. Cytoplasmic vesicle {ECO:0000250}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:24269233}. Cell membrane {ECO:0000269|PubMed:24269233}.
Q96GR4	reviewed	ZDH12_HUMAN	Palmitoyltransferase ZDHHC12 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 12) (DHHC-12) (Zinc finger DHHC domain-containing protein 12) (Zinc finger protein 400)	ZDHHC12 ZNF400 PSEC0008	Homo sapiens (Human)	267	FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:36586411). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (By similarity). Thereby, indirectly regulates GABAergic synaptic transmission (By similarity). Acts as an inhibitor of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, thereby promoting NLRP3 degradation by the chaperone-mediated autophagy (CMA) process (PubMed:36586411). {ECO:0000250|UniProtKB:Q8VC90, ECO:0000269|PubMed:36586411}.		gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8VC90}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16647879}; Multi-pass membrane protein {ECO:0000255}.
Q96GS4	reviewed	BORC6_HUMAN	BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin)	BORCS6 C17orf59	Homo sapiens (Human)	357	FUNCTION: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000269|PubMed:25898167}.		lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]	BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]	identical protein binding [GO:0042802]	BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; identical protein binding [GO:0042802]; lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000305|PubMed:25898167}.
Q96GS6	reviewed	AB17A_HUMAN	Alpha/beta hydrolase domain-containing protein 17A (Abhydrolase domain-containing protein 17A) (EC 3.1.2.22)	ABHD17A C19orf27 FAM108A1	Homo sapiens (Human)	310	FUNCTION: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards NRAS (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). May have depalmitoylating activity towards MAP6 (By similarity). {ECO:0000250|UniProtKB:Q5XIJ5, ECO:0000269|PubMed:26701913}.		negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; protein depalmitoylation [GO:0002084]; protein localization to membrane [GO:0072657]; regulation of postsynapse organization [GO:0099175]	dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic recycling endosome membrane [GO:0098944]; recycling endosome membrane [GO:0055038]	palmitoyl-(protein) hydrolase activity [GO:0008474]	dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic recycling endosome membrane [GO:0098944]; recycling endosome membrane [GO:0055038]; palmitoyl-(protein) hydrolase activity [GO:0008474]; negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; protein depalmitoylation [GO:0002084]; protein localization to membrane [GO:0072657]; regulation of postsynapse organization [GO:0099175]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26701913}; Lipid-anchor {ECO:0000269|PubMed:26701913}; Cytoplasmic side {ECO:0000269|PubMed:26701913}. Endosome membrane {ECO:0000269|PubMed:26701913}; Lipid-anchor {ECO:0000269|PubMed:26701913}; Cytoplasmic side {ECO:0000269|PubMed:26701913}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q5XIJ5}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q5XIJ5}.
Q96GV9	reviewed	MACIR_HUMAN	Macrophage immunometabolism regulator	MACIR C5orf30	Homo sapiens (Human)	206	FUNCTION: Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages (PubMed:30659109). The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis (PubMed:30659109). May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962). {ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:30659109}.		cilium assembly [GO:0060271]; epithelial cell migration [GO:0010631]; fibroblast migration [GO:0010761]; inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of inflammatory response [GO:0050728]; protein transport [GO:0015031]	ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]		ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cilium assembly [GO:0060271]; epithelial cell migration [GO:0010631]; fibroblast migration [GO:0010761]; inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of inflammatory response [GO:0050728]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:30659109}. Cell projection, cilium {ECO:0000269|PubMed:22085962}. Note=Localizes to the transition zone and proximal cilium in addition to being found throughout the cytoplasm. {ECO:0000269|PubMed:22085962}.
Q96GW7	reviewed	PGCB_HUMAN	Brevican core protein (Brain-enriched hyaluronan-binding protein) (BEHAB) (Chondroitin sulfate proteoglycan 7)	BCAN BEHAB CSPG7 UNQ2525/PRO6018	Homo sapiens (Human)	911	FUNCTION: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.		cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; hippocampus development [GO:0021766]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]; synapse maturation [GO:0060074]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; perineuronal net [GO:0072534]; side of membrane [GO:0098552]; synapse [GO:0045202]	carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; perineuronal net [GO:0072534]; side of membrane [GO:0098552]; synapse [GO:0045202]; carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; hippocampus development [GO:0021766]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]; synapse maturation [GO:0060074]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25326458}.; SUBCELLULAR LOCATION: [Isoform 1]: Secreted, extracellular space, extracellular matrix.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane; Lipid-anchor, GPI-anchor.
Q96GW9	reviewed	SYMM_HUMAN	Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS)	MARS2	Homo sapiens (Human)	593			methionyl-tRNA aminoacylation [GO:0006431]; tRNA aminoacylation for protein translation [GO:0006418]	mitochondrial matrix [GO:0005759]	ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]	mitochondrial matrix [GO:0005759]; ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]; methionyl-tRNA aminoacylation [GO:0006431]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305}.
Q96GX1	reviewed	TECT2_HUMAN	Tectonic-2	TCTN2 C12orf38 TECT2	Homo sapiens (Human)	697	FUNCTION: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity). {ECO:0000250}.		cilium assembly [GO:0060271]; protein localization to ciliary transition zone [GO:1904491]; smoothened signaling pathway [GO:0007224]	ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; MKS complex [GO:0036038]		ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; MKS complex [GO:0036038]; cilium assembly [GO:0060271]; protein localization to ciliary transition zone [GO:1904491]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250}.
Q96GX5	reviewed	GWL_HUMAN	Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L)	MASTL GW GWL THC2	Homo sapiens (Human)	879	FUNCTION: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157}.	MISCELLANEOUS: Reduced levels of MASTL by RNAi causes mitotic abnormalities that consist of delay in G(2) phase and slow chromosome condensation. Cells that enter and progress through mitosis often fail to completely separate their sister chromatids in anaphase leading to the formation of 4N G(1) cells subsequent to failure of cytokinesis (PubMed:20818157, PubMed:20538976).	cell division [GO:0051301]; DNA damage response [GO:0006974]; female meiosis II [GO:0007147]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular signal transduction [GO:0035556]; mitotic cell cycle [GO:0000278]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; phosphorylation [GO:0016310]; regulation of cell cycle [GO:0051726]	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein phosphatase 2A binding [GO:0051721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein phosphatase 2A binding [GO:0051721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell division [GO:0051301]; DNA damage response [GO:0006974]; female meiosis II [GO:0007147]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular signal transduction [GO:0035556]; mitotic cell cycle [GO:0000278]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; phosphorylation [GO:0016310]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20818157}. Nucleus {ECO:0000269|PubMed:19460416, ECO:0000269|PubMed:20818157}. Cleavage furrow {ECO:0000269|PubMed:20818157}. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow. {ECO:0000269|PubMed:20818157}.
Q96GX9	reviewed	MTNB_HUMAN	Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein) (hAPIP)	APIP CGI-29	Homo sapiens (Human)	242	FUNCTION: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:22837397, ECO:0000269|PubMed:23285211, ECO:0000269|PubMed:24367089}.		apoptotic process [GO:0006915]; L-methionine salvage from methylthioadenosine [GO:0019509]; L-methionine salvage from S-adenosylmethionine [GO:0019284]; negative regulation of apoptotic process [GO:0043066]; protein homotetramerization [GO:0051289]; pyroptosis [GO:0070269]; regulation of ERK1 and ERK2 cascade [GO:0070372]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	identical protein binding [GO:0042802]; methylthioribulose 1-phosphate dehydratase activity [GO:0046570]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; methylthioribulose 1-phosphate dehydratase activity [GO:0046570]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; L-methionine salvage from methylthioadenosine [GO:0019509]; L-methionine salvage from S-adenosylmethionine [GO:0019284]; negative regulation of apoptotic process [GO:0043066]; protein homotetramerization [GO:0051289]; pyroptosis [GO:0070269]; regulation of ERK1 and ERK2 cascade [GO:0070372]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}.
Q96GY3	reviewed	LIN37_HUMAN	Protein lin-37 homolog (Antolefinin)	LIN37 MSTP064	Homo sapiens (Human)	246			negative regulation of transcription by RNA polymerase II [GO:0000122]	Myb complex [GO:0031523]; nucleoplasm [GO:0005654]; transcription repressor complex [GO:0017053]		Myb complex [GO:0031523]; nucleoplasm [GO:0005654]; transcription repressor complex [GO:0017053]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
Q96GZ6	reviewed	S41A3_HUMAN	Solute carrier family 41 member 3	SLC41A3	Homo sapiens (Human)	507	FUNCTION: Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the mitochondrial inner membrane. {ECO:0000269|PubMed:27302215}.		mitochondrial magnesium ion transmembrane transport [GO:0045016]	mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]	magnesium:sodium antiporter activity [GO:0061768]	mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]; magnesium:sodium antiporter activity [GO:0061768]; mitochondrial magnesium ion transmembrane transport [GO:0045016]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:27302215}; Multi-pass membrane protein {ECO:0000255}.
Q96H15	reviewed	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD-4) (T-cell immunoglobulin mucin receptor 4) (TIM-4) (T-cell membrane protein 4)	TIMD4 TIM4	Homo sapiens (Human)	378	FUNCTION: Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways (By similarity). Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:32703939, PubMed:34067457). Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (PubMed:32640697). Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of LKB1/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (By similarity). {ECO:0000250|UniProtKB:Q6U7R4, ECO:0000269|PubMed:32640697, ECO:0000269|PubMed:32703939, ECO:0000269|PubMed:34067457}.; FUNCTION: (Microbial infection) Plays a positive role in exosome-mediated trafficking of HIV-1 virus and its entry into immune cells. {ECO:0000269|PubMed:28740388}.		apoptotic cell clearance [GO:0043277]; cytoskeletal rearrangement involved in phagocytosis, engulfment [GO:0060097]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	phosphatidylserine binding [GO:0001786]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; phosphatidylserine binding [GO:0001786]; apoptotic cell clearance [GO:0043277]; cytoskeletal rearrangement involved in phagocytosis, engulfment [GO:0060097]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32640697, ECO:0000269|PubMed:32703939, ECO:0000269|PubMed:34067457}; Single-pass type I membrane protein {ECO:0000305}. Secreted, extracellular exosome {ECO:0000269|PubMed:28740388}.
Q96H20	reviewed	SNF8_HUMAN	Vacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22)	SNF8 EAP30	Homo sapiens (Human)	258	FUNCTION: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:17714434, ECO:0000269|PubMed:17959629, ECO:0000269|PubMed:18031739, ECO:0000269|PubMed:22660413}.		early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; localization [GO:0051179]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of protein catabolic process [GO:0042176]; regulation of protein complex stability [GO:0061635]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; transcription regulator complex [GO:0005667]	channel regulator activity [GO:0016247]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; transcription regulator complex [GO:0005667]; channel regulator activity [GO:0016247]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; localization [GO:0051179]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of protein catabolic process [GO:0042176]; regulation of protein complex stability [GO:0061635]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane. Nucleus {ECO:0000305}. Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation.
Q96H22	reviewed	CENPN_HUMAN	Centromere protein N (CENP-N) (Interphase centromere complex protein 32)	CENPN C16orf60 ICEN32 BM-309	Homo sapiens (Human)	339	FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}.		CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]	cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.
Q96H55	reviewed	MYO19_HUMAN	Unconventional myosin-XIX (Myosin head domain-containing protein 1)	MYO19 MYOHD1	Homo sapiens (Human)	970	FUNCTION: Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824). {ECO:0000250|UniProtKB:Q5SV80, ECO:0000269|PubMed:19932026, ECO:0000269|PubMed:25447992, ECO:0000305|PubMed:23568824}.		actin filament organization [GO:0007015]; mitochondrion migration along actin filament [GO:0034642]; mitocytosis [GO:0160040]; regulation of cytokinesis [GO:0032465]; regulation of mitochondrial fission [GO:0090140]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; myosin complex [GO:0016459]; vesicle [GO:0031982]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microfilament motor activity [GO:0000146]; myosin light chain binding [GO:0032027]; plus-end directed microfilament motor activity [GO:0060002]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; myosin complex [GO:0016459]; vesicle [GO:0031982]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microfilament motor activity [GO:0000146]; myosin light chain binding [GO:0032027]; plus-end directed microfilament motor activity [GO:0060002]; actin filament organization [GO:0007015]; mitochondrion migration along actin filament [GO:0034642]; mitocytosis [GO:0160040]; regulation of cytokinesis [GO:0032465]; regulation of mitochondrial fission [GO:0090140]; vesicle transport along actin filament [GO:0030050]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:19932026, ECO:0000269|PubMed:23568824, ECO:0000269|PubMed:25447992, ECO:0000269|PubMed:26659663, ECO:0000269|PubMed:27126804}; Peripheral membrane protein {ECO:0000269|PubMed:27126804}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19932026}.
Q96H72	reviewed	S39AD_HUMAN	Zinc transporter ZIP13 (LIV-1 subfamily of ZIP zinc transporter 9) (LZT-Hs9) (Solute carrier family 39 member 13) (Zrt- and Irt-like protein 13) (ZIP-13)	SLC39A13 ZIP13	Homo sapiens (Human)	371	FUNCTION: Functions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed:21917916, PubMed:23213233). May regulate beige adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZH0, ECO:0000269|PubMed:21917916, ECO:0000269|PubMed:23213233}.		brown fat cell differentiation [GO:0050873]; connective tissue development [GO:0061448]; intracellular zinc ion homeostasis [GO:0006882]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	protein homodimerization activity [GO:0042803]; zinc ion transmembrane transporter activity [GO:0005385]	cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; protein homodimerization activity [GO:0042803]; zinc ion transmembrane transporter activity [GO:0005385]; brown fat cell differentiation [GO:0050873]; connective tissue development [GO:0061448]; intracellular zinc ion homeostasis [GO:0006882]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:21917916, ECO:0000269|PubMed:31412620}; Multi-pass membrane protein {ECO:0000269|PubMed:21917916}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:23213233}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:31412620}.
Q96H86	reviewed	ZN764_HUMAN	Zinc finger protein 764	ZNF764	Homo sapiens (Human)	408	FUNCTION: Zinc finger protein that functions as a cofactor for steroid hormone receptors, such as NR3C1/GR (PubMed:28139699). Directs NR3C1/GR transcriptional activity toward specific biologic pathways by changing NR3C1/GR binding and transcriptional activity on the glucocorticoid-responsive genes (PubMed:28139699). {ECO:0000269|PubMed:28139699}.		cellular response to glucocorticoid stimulus [GO:0071385]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coregulator activity [GO:0003712]	nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coregulator activity [GO:0003712]; cellular response to glucocorticoid stimulus [GO:0071385]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28139699}.
Q96H96	reviewed	COQ2_HUMAN	4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (4-hydroxybenzoate decaprenyltransferase) (COQ2 homolog) (hCOQ2) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase)	COQ2 CL640	Homo sapiens (Human)	371	FUNCTION: Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis (PubMed:15153069, PubMed:17374725, PubMed:16400613, PubMed:20526342). Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-decaprenyl diphosphate) (PubMed:15153069, PubMed:17374725, PubMed:16400613, PubMed:20526342). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls (decaprenyl) producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9 (PubMed:15153069, PubMed:16400613). However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10 (PubMed:15153069). Plays a central role in the biosynthesis of CoQ10 (PubMed:15153069, PubMed:17374725, PubMed:16400613). CoQ10 is a vital molecule that transports electrons from mitochondrial respiratory chain complexes (PubMed:17374725, PubMed:27493029, PubMed:16400613). CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway (PubMed:17374725, PubMed:16400613). Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner (By similarity). {ECO:0000250|UniProtKB:Q499N4, ECO:0000269|PubMed:15153069, ECO:0000269|PubMed:16400613, ECO:0000269|PubMed:17374725, ECO:0000269|PubMed:20526342, ECO:0000269|PubMed:27493029, ECO:0000303|PubMed:15153069, ECO:0000303|PubMed:16400613, ECO:0000303|PubMed:17374725}.	MISCELLANEOUS: [Isoform 4]: Potential minor and functional isoform produced by alternative initiation. {ECO:0000305|PubMed:27493029}.; MISCELLANEOUS: [Isoform 5]: Potential minor and functional isoform produced by alternative initiation. {ECO:0000305|PubMed:27493029}.; MISCELLANEOUS: [Isoform 6]: Potential minor and functional isoform produced by alternative initiation. {ECO:0000305|PubMed:27493029}.	glycerol metabolic process [GO:0006071]; isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744]	mitochondrial inner membrane [GO:0005743]	4-hydroxybenzoate decaprenyltransferase activity [GO:0002083]; 4-hydroxybenzoate nonaprenyltransferase activity [GO:0047293]; 4-hydroxybenzoate octaprenyltransferase activity [GO:0008412]; prenyltransferase activity [GO:0004659]	mitochondrial inner membrane [GO:0005743]; 4-hydroxybenzoate decaprenyltransferase activity [GO:0002083]; 4-hydroxybenzoate nonaprenyltransferase activity [GO:0047293]; 4-hydroxybenzoate octaprenyltransferase activity [GO:0008412]; prenyltransferase activity [GO:0004659]; glycerol metabolic process [GO:0006071]; isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03189, ECO:0000269|PubMed:27493029}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03189}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03189}.
Q96HA1	reviewed	P121A_HUMAN	Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa)	POM121 KIAA0618 NUP121 POM121A	Homo sapiens (Human)	1249	FUNCTION: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.		mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]	endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]	nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]	endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:17900573}. Nucleus membrane {ECO:0000269|PubMed:17900573}; Single-pass membrane protein {ECO:0000269|PubMed:17900573}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase. {ECO:0000250}.
Q96HA7	reviewed	TONSL_HUMAN	Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)	TONSL IKBR NFKBIL2	Homo sapiens (Human)	1378	FUNCTION: Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:21113133, PubMed:26527279, PubMed:27797818, PubMed:29478807, PubMed:27338793, PubMed:30773278). The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication (PubMed:21055983, PubMed:21055984, PubMed:21055985). It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:27797818, PubMed:29478807). Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination (PubMed:27797818, PubMed:29478807). Within the complex, TONSL acts as histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones (PubMed:29478807, PubMed:27338793). Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1 (PubMed:27338793). {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985, ECO:0000269|PubMed:21113133, ECO:0000269|PubMed:26527279, ECO:0000269|PubMed:27338793, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30773278}.		double-strand break repair via homologous recombination [GO:0000724]; protein localization to chromatin [GO:0071168]; replication fork processing [GO:0031297]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]	histone binding [GO:0042393]; histone reader activity [GO:0140566]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; double-strand break repair via homologous recombination [GO:0000724]; protein localization to chromatin [GO:0071168]; replication fork processing [GO:0031297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:9242696}. Chromosome {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:26527279, ECO:0000269|PubMed:27338793, ECO:0000269|PubMed:29478807}. Cytoplasm {ECO:0000269|PubMed:7738005}. Note=Mainly nuclear (PubMed:21055983, PubMed:21055984). Localizes to DNA damage sites, accumulates at stressed replication forks (PubMed:21055983, PubMed:21055984, PubMed:26527279, PubMed:27338793). Recruited to stalled or collapsed replication forks following histone replacement by histone chaperones ASF1A and the CAF-1 complex: TONSL acts as histone reader that recognizes and binds newly synthesized histones (PubMed:29478807). {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:26527279, ECO:0000269|PubMed:27338793, ECO:0000269|PubMed:29478807}.
Q96HA8	reviewed	NTAQ1_HUMAN	Protein N-terminal glutamine amidohydrolase (EC 3.5.1.122) (Protein NH2-terminal glutamine deamidase) (N-terminal Gln amidase) (Nt(Q)-amidase) (WDYHV motif-containing protein 1)	NTAQ1 C8orf32 WDYHV1	Homo sapiens (Human)	205	FUNCTION: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. {ECO:0000250|UniProtKB:Q80WB5}.		protein modification process [GO:0036211]	cytosol [GO:0005829]; nucleus [GO:0005634]	protein-N-terminal asparagine amidohydrolase activity [GO:0008418]; protein-N-terminal glutamine amidohydrolase activity [GO:0070773]	cytosol [GO:0005829]; nucleus [GO:0005634]; protein-N-terminal asparagine amidohydrolase activity [GO:0008418]; protein-N-terminal glutamine amidohydrolase activity [GO:0070773]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q80WB5}. Nucleus {ECO:0000250|UniProtKB:Q80WB5}.
Q96HA9	reviewed	PX11C_HUMAN	Peroxisomal membrane protein 11C (Peroxin-11C) (Peroxisomal biogenesis factor 11C) (Protein PEX11 homolog gamma) (PEX11-gamma)	PEX11G PEX11C	Homo sapiens (Human)	241	FUNCTION: Promotes membrane protrusion and elongation on the peroxisomal surface. {ECO:0000269|PubMed:20826455}.		peroxisome fission [GO:0016559]; regulation of peroxisome size [GO:0044375]	peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]		peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; peroxisome fission [GO:0016559]; regulation of peroxisome size [GO:0044375]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:12417726, ECO:0000269|PubMed:12559946, ECO:0000269|PubMed:20826455}; Multi-pass membrane protein {ECO:0000269|PubMed:12417726, ECO:0000269|PubMed:12559946}.
Q96HB5	reviewed	CC120_HUMAN	Coiled-coil domain-containing protein 120	CCDC120 JM11	Homo sapiens (Human)	630	FUNCTION: Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}.		microtubule anchoring at centrosome [GO:0034454]; protein localization [GO:0008104]	centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; endosome [GO:0005768]; growth cone [GO:0030426]		centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; endosome [GO:0005768]; growth cone [GO:0030426]; microtubule anchoring at centrosome [GO:0034454]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28422092}. Cytoplasm {ECO:0000269|PubMed:25326380}. Cell projection, neuron projection {ECO:0000269|PubMed:25326380}. Cell projection, growth cone {ECO:0000269|PubMed:25326380}. Endosome {ECO:0000269|PubMed:25326380}. Note=Localizes to the subdistal appendages of mother centrioles and proximal ends of both centrioles in interphase cells (PubMed:28422092). Recruited to subdistal appendages by ODF2 (PubMed:28422092). In differentiating neuroblastoma cells, colocalizes with CYTH2 in both neurite shaft and growth cone areas (PubMed:25326380). Partially colocalizes with endosomes along neurites in differentiating neuroblastoma cells (PubMed:25326380). {ECO:0000269|PubMed:25326380, ECO:0000269|PubMed:28422092}.
Q96HC4	reviewed	PDLI5_HUMAN	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)	PDLIM5 ENH L9	Homo sapiens (Human)	596	FUNCTION: May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}.		actin cytoskeleton organization [GO:0030036]; cell growth involved in cardiac muscle cell development [GO:0061049]; heart development [GO:0007507]; muscle structure development [GO:0061061]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of synapse assembly [GO:0051963]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cell projection [GO:0042995]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; actinin binding [GO:0042805]; cadherin binding involved in cell-cell adhesion [GO:0098641]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein kinase C binding [GO:0005080]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cell projection [GO:0042995]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; actinin binding [GO:0042805]; cadherin binding involved in cell-cell adhesion [GO:0098641]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein kinase C binding [GO:0005080]; actin cytoskeleton organization [GO:0030036]; cell growth involved in cardiac muscle cell development [GO:0061049]; heart development [GO:0007507]; muscle structure development [GO:0061061]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of synapse assembly [GO:0051963]	SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250|UniProtKB:Q62920}. Presynapse {ECO:0000250|UniProtKB:Q62920}. Postsynapse {ECO:0000250|UniProtKB:Q62920}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q62920}. Note=Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons. {ECO:0000250|UniProtKB:Q62920}.
Q96HD1	reviewed	CREL1_HUMAN	Protein disulfide isomerase CRELD1 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 1)	CRELD1 CIRRIN UNQ188/PRO214	Homo sapiens (Human)	420	FUNCTION: Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q91XD7, ECO:0000250|UniProtKB:Q9CYA0}.		cardiac septum development [GO:0003279]; endocardial cushion development [GO:0003197]	collagen-containing extracellular matrix [GO:0062023]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; protein disulfide isomerase activity [GO:0003756]	collagen-containing extracellular matrix [GO:0062023]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; protein disulfide isomerase activity [GO:0003756]; cardiac septum development [GO:0003279]; endocardial cushion development [GO:0003197]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96HD9	reviewed	ACY3_HUMAN	N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (EC 3.5.1.114) (Acylase III) (Aminoacylase-3) (ACY-3) (Aspartoacylase-2) (Hepatitis C virus core-binding protein 1) (HCBP1) (HCV core-binding protein 1)	ACY3 ASPA2	Homo sapiens (Human)	319	FUNCTION: Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity). {ECO:0000250}.			apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	aminoacylase activity [GO:0004046]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; aminoacylase activity [GO:0004046]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:19486448}; Peripheral membrane protein {ECO:0000269|PubMed:19486448}. Cytoplasm {ECO:0000269|PubMed:19486448}. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.
Q96HE7	reviewed	ERO1A_HUMAN	ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha)	ERO1A ERO1L UNQ434/PRO865	Homo sapiens (Human)	468	FUNCTION: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins (PubMed:29858230). Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:10970843, ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:12403808, ECO:0000269|PubMed:18833192, ECO:0000269|PubMed:18971943, ECO:0000269|PubMed:23027870, ECO:0000269|PubMed:29858230}.		brown fat cell differentiation [GO:0050873]; cell redox homeostasis [GO:0045454]; cellular response to hypoxia [GO:0071456]; chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum unfolded protein response [GO:0030968]; extracellular matrix organization [GO:0030198]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein maturation by protein folding [GO:0022417]; protein modification process [GO:0036211]; release of sequestered calcium ion into cytosol [GO:0051209]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; response to temperature stimulus [GO:0009266]	dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972]	dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972]; brown fat cell differentiation [GO:0050873]; cell redox homeostasis [GO:0045454]; cellular response to hypoxia [GO:0071456]; chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum unfolded protein response [GO:0030968]; extracellular matrix organization [GO:0030198]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein maturation by protein folding [GO:0022417]; protein modification process [GO:0036211]; release of sequestered calcium ion into cytosol [GO:0051209]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; response to temperature stimulus [GO:0009266]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Peripheral membrane protein {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Lumenal side {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}. Golgi apparatus lumen {ECO:0000269|PubMed:29858230}. Secreted {ECO:0000269|PubMed:29858230}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8R4A1}. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum (PubMed:29858230). In neurons, it localizes to dendrites (By similarity). {ECO:0000250|UniProtKB:Q8R4A1, ECO:0000269|PubMed:29858230}.
Q96HE8	reviewed	TMM80_HUMAN	Transmembrane protein 80	TMEM80	Homo sapiens (Human)	216			non-motile cilium assembly [GO:1905515]	ciliary transition zone [GO:0035869]; membrane [GO:0016020]		ciliary transition zone [GO:0035869]; membrane [GO:0016020]; non-motile cilium assembly [GO:1905515]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9D3H0}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250|UniProtKB:Q9D3H0}.
Q96HF1	reviewed	SFRP2_HUMAN	Secreted frizzled-related protein 2 (FRP-2) (sFRP-2) (Secreted apoptosis-related protein 1) (SARP-1)	SFRP2 FRP2 SARP1 FKSG12 UNQ361/PRO697	Homo sapiens (Human)	295	FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.		BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; canonical Wnt signaling pathway [GO:0060070]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell apoptotic process [GO:0010659]; cell-cell signaling [GO:0007267]; cellular response to extracellular stimulus [GO:0031668]; cellular response to X-ray [GO:0071481]; chondrocyte development [GO:0002063]; collagen fibril organization [GO:0030199]; convergent extension involved in axis elongation [GO:0060028]; digestive tract morphogenesis [GO:0048546]; embryonic digit morphogenesis [GO:0042733]; hematopoietic stem cell proliferation [GO:0071425]; male gonad development [GO:0008584]; mesodermal cell fate specification [GO:0007501]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of dermatome development [GO:0061185]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of mesodermal cell fate specification [GO:0042662]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of planar cell polarity pathway involved in axis elongation [GO:2000041]; negative regulation of Wnt signaling pathway [GO:0030178]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in axis elongation [GO:0003402]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; regulation of midbrain dopaminergic neuron differentiation [GO:1904956]; regulation of neuron projection development [GO:0010975]; regulation of stem cell division [GO:2000035]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; sclerotome development [GO:0061056]; stem cell fate specification [GO:0048866]; Wnt signaling pathway involved in somitogenesis [GO:0090244]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]	endopeptidase activator activity [GO:0061133]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; receptor ligand activity [GO:0048018]; Wnt-protein binding [GO:0017147]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; endopeptidase activator activity [GO:0061133]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; receptor ligand activity [GO:0048018]; Wnt-protein binding [GO:0017147]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; canonical Wnt signaling pathway [GO:0060070]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell apoptotic process [GO:0010659]; cell-cell signaling [GO:0007267]; cellular response to extracellular stimulus [GO:0031668]; cellular response to X-ray [GO:0071481]; chondrocyte development [GO:0002063]; collagen fibril organization [GO:0030199]; convergent extension involved in axis elongation [GO:0060028]; digestive tract morphogenesis [GO:0048546]; embryonic digit morphogenesis [GO:0042733]; hematopoietic stem cell proliferation [GO:0071425]; male gonad development [GO:0008584]; mesodermal cell fate specification [GO:0007501]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of dermatome development [GO:0061185]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of mesodermal cell fate specification [GO:0042662]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of planar cell polarity pathway involved in axis elongation [GO:2000041]; negative regulation of Wnt signaling pathway [GO:0030178]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in axis elongation [GO:0003402]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; regulation of midbrain dopaminergic neuron differentiation [GO:1904956]; regulation of neuron projection development [GO:0010975]; regulation of stem cell division [GO:2000035]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; sclerotome development [GO:0061056]; stem cell fate specification [GO:0048866]; Wnt signaling pathway involved in somitogenesis [GO:0090244]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q96HH6	reviewed	TMM19_HUMAN	Transmembrane protein 19	TMEM19	Homo sapiens (Human)	336				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96HH9	reviewed	GRM2B_HUMAN	GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2)	GRAMD2B GRAMD3 NS3TP2	Homo sapiens (Human)	432				cytoplasmic microtubule [GO:0005881]	identical protein binding [GO:0042802]	cytoplasmic microtubule [GO:0005881]; identical protein binding [GO:0042802]	
Q96HI0	reviewed	SENP5_HUMAN	Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5)	SENP5 FKSG45	Homo sapiens (Human)	755	FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}.		cell cycle [GO:0007049]; cell division [GO:0051301]; protein sumoylation [GO:0016925]; proteolysis [GO:0006508]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	deSUMOylase activity [GO:0016929]; SUMO-specific endopeptidase activity [GO:0070139]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; deSUMOylase activity [GO:0016929]; SUMO-specific endopeptidase activity [GO:0070139]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein sumoylation [GO:0016925]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}.
Q96HJ3	reviewed	CCD34_HUMAN	Coiled-coil domain-containing protein 34 (Renal carcinoma antigen NY-REN-41)	CCDC34 RAMA3 L15	Homo sapiens (Human)	373	FUNCTION: Involved in spermatogenesis. Has a probable role in anterograde intraflagellar transport which is essential for the formation of sperm flagella. {ECO:0000269|PubMed:34348960}.	MISCELLANEOUS: Antigen recognized by autologous antibody in patients with renal-cell carcinoma.	spermatogenesis [GO:0007283]	sperm midpiece [GO:0097225]		sperm midpiece [GO:0097225]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:34348960}. Note=Mainly located in the mid-piece of sperm flagella. {ECO:0000269|PubMed:34348960}.
Q96HJ5	reviewed	MS4A3_HUMAN	Membrane-spanning 4-domains subfamily A member 3 (CD20 antigen-like protein) (Hematopoietic-specific transmembrane protein 4) (HTm4)	MS4A3 CD20L HTM4	Homo sapiens (Human)	214	FUNCTION: Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP). {ECO:0000269|PubMed:11781350}.			perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]		perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Located in the perinuclear area.
Q96HN2	reviewed	SAHH3_HUMAN	Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.13.2.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2)	AHCYL2 KIAA0828	Homo sapiens (Human)	611	FUNCTION: May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705). {ECO:0000250|UniProtKB:A6QLP2, ECO:0000269|PubMed:19220705}.		one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; neuron projection [GO:0043005]	hydrolase activity [GO:0016787]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; neuron projection [GO:0043005]; hydrolase activity [GO:0016787]; one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A6QLP2, ECO:0000250|UniProtKB:Q68FL4}. Microsome {ECO:0000250|UniProtKB:Q68FL4}. Note=Associates with membranes when phosphorylated, probably through interaction with ITPR1. {ECO:0000250|UniProtKB:Q68FL4}.
Q96HP0	reviewed	DOCK6_HUMAN	Dedicator of cytokinesis protein 6	DOCK6 KIAA1395	Homo sapiens (Human)	2047	FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}.		small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17196961}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17196961}. Note=Mainly located near the cell surface.
Q96HP8	reviewed	T176A_HUMAN	Transmembrane protein 176A (Hepatocellular carcinoma-associated antigen 112)	TMEM176A HCA112	Homo sapiens (Human)	235			negative regulation of dendritic cell differentiation [GO:2001199]	membrane [GO:0016020]		membrane [GO:0016020]; negative regulation of dendritic cell differentiation [GO:2001199]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96HR3	reviewed	MED30_HUMAN	Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25)	MED30 THRAP6 TRAP25	Homo sapiens (Human)	178	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:11909976, ECO:0000269|PubMed:16595664}.		positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96HR8	reviewed	NAF1_HUMAN	H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1)	NAF1	Homo sapiens (Human)	494	FUNCTION: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}.		box H/ACA snoRNP assembly [GO:0000493]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; ribosome biogenesis [GO:0042254]; RNA stabilization [GO:0043489]; snoRNA guided rRNA pseudouridine synthesis [GO:0000454]; telomerase holoenzyme complex assembly [GO:1905323]; telomerase RNA stabilization [GO:0090669]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; box H/ACA snoRNP assembly [GO:0000493]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; ribosome biogenesis [GO:0042254]; RNA stabilization [GO:0043489]; snoRNA guided rRNA pseudouridine synthesis [GO:0000454]; telomerase holoenzyme complex assembly [GO:1905323]; telomerase RNA stabilization [GO:0090669]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus. Absent from the nucleolus (By similarity). {ECO:0000250}.
Q96HR9	reviewed	REEP6_HUMAN	Receptor expression-enhancing protein 6 (Polyposis locus protein 1-like 1)	REEP6 C19orf32 DP1L1	Homo sapiens (Human)	211	FUNCTION: Required for correct function and survival of retinal photoreceptors (PubMed:27889058). Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q9JM62, ECO:0000269|PubMed:27889058}.		detection of light stimulus involved in visual perception [GO:0050908]; endoplasmic reticulum organization [GO:0007029]; regulation of intracellular transport [GO:0032386]	clathrin-coated vesicle membrane [GO:0030665]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]		clathrin-coated vesicle membrane [GO:0030665]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; detection of light stimulus involved in visual perception [GO:0050908]; endoplasmic reticulum organization [GO:0007029]; regulation of intracellular transport [GO:0032386]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24098485, ECO:0000269|PubMed:27889058}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q9JM62}; Multi-pass membrane protein {ECO:0000255}.
Q96HS1	reviewed	PGAM5_HUMAN	Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5)	PGAM5	Homo sapiens (Human)	289	FUNCTION: Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414}.		macroautophagy [GO:0016236]; necroptotic process [GO:0070266]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of mitochondrial fission [GO:0090141]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GTPase activator activity [GO:0005096]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; GTPase activator activity [GO:0005096]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]; macroautophagy [GO:0016236]; necroptotic process [GO:0070266]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of mitochondrial fission [GO:0090141]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18387606}; Single-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:22915595}; Single-pass membrane protein {ECO:0000255}. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
Q96HT8	reviewed	MR1L1_HUMAN	MORF4 family-associated protein 1-like 1	MRFAP1L1 PP784	Homo sapiens (Human)	127					identical protein binding [GO:0042802]	identical protein binding [GO:0042802]	
Q96HU1	reviewed	SGSM3_HUMAN	Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP)	SGSM3 MAP RABGAPLP RUTBC3	Homo sapiens (Human)	749	FUNCTION: May play a cooperative role in NF2-mediated growth suppression of cells. {ECO:0000269|PubMed:15541357}.		cell cycle [GO:0007049]; plasma membrane to endosome transport [GO:0048227]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein catabolic process [GO:0045732]; Rap protein signal transduction [GO:0032486]; regulation of cell cycle [GO:0051726]; regulation of Rab protein signal transduction [GO:0032483]	cytosol [GO:0005829]; gap junction [GO:0005921]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; gap junction [GO:0005921]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; cell cycle [GO:0007049]; plasma membrane to endosome transport [GO:0048227]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein catabolic process [GO:0045732]; Rap protein signal transduction [GO:0032486]; regulation of cell cycle [GO:0051726]; regulation of Rab protein signal transduction [GO:0032483]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15849434}.
Q96HW7	reviewed	INT4_HUMAN	Integrator complex subunit 4 (Int4)	INTS4 MSTP093	Homo sapiens (Human)	963	FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180]	integrator complex [GO:0032039]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		integrator complex [GO:0032039]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23904267}.
Q96HY6	reviewed	DDRGK_HUMAN	DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1)	DDRGK1 C20orf116 UFBP1	Homo sapiens (Human)	314	FUNCTION: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) (PubMed:32160526). In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets (PubMed:32160526). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (PubMed:28128204, PubMed:32160526). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response (By similarity). Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated. transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:23675531). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186). {ECO:0000250|UniProtKB:Q80WW9, ECO:0000269|PubMed:23675531, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:28128204, ECO:0000269|PubMed:28263186, ECO:0000269|PubMed:32160526}.		cartilage development [GO:0051216]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of metallopeptidase activity [GO:1905050]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein K69-linked ufmylation [GO:1990592]; protein localization to endoplasmic reticulum [GO:0070972]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleolus [GO:0005730]	RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin-like protein ligase binding [GO:0044389]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleolus [GO:0005730]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin-like protein ligase binding [GO:0044389]; cartilage development [GO:0051216]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of metallopeptidase activity [GO:1905050]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein K69-linked ufmylation [GO:1990592]; protein localization to endoplasmic reticulum [GO:0070972]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:32160526}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:32160526}. Note=Localizes to the endoplasmic reticulum membrane in response to endoplasmic reticulum stress. {ECO:0000269|PubMed:32160526}.
Q96HY7	reviewed	DHTK1_HUMAN	2-oxoadipate dehydrogenase complex component E1 (E1a) (OADC-E1) (OADH-E1) (EC 1.2.4.-) (2-oxoadipate dehydrogenase, mitochondrial) (Alpha-ketoadipate dehydrogenase) (Alpha-KADH-E1) (Dehydrogenase E1 and transketolase domain-containing protein 1) (Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial)	DHTKD1 KIAA1630	Homo sapiens (Human)	919	FUNCTION: 2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC) (PubMed:29191460, PubMed:29752936, PubMed:32303640, PubMed:32633484, PubMed:32695416). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC (PubMed:29191460, PubMed:32695416). Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (Probable) (PubMed:29752936, PubMed:32303640, PubMed:32633484). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate (PubMed:29191460, PubMed:29752936, PubMed:32633484, PubMed:32695416). Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate (Probable). {ECO:0000269|PubMed:29191460, ECO:0000269|PubMed:29752936, ECO:0000269|PubMed:32303640, ECO:0000269|PubMed:32633484, ECO:0000269|PubMed:32695416, ECO:0000305|PubMed:29191460, ECO:0000305|PubMed:29752936, ECO:0000305|PubMed:32303640, ECO:0000305|PubMed:32633484, ECO:0000305|PubMed:32695416}.	MISCELLANEOUS: The mitochondrial 2-oxoglutarate and 2-oxoadipate dehydrogenase complexes (OGDHC and OADHC, respectively) share their E2 (DLST) and E3 (dihydrolipoyl dehydrogenase or DLD) components, but the E1 component is specific to each complex (E1o and E1a, respectively). {ECO:0000303|PubMed:29752936, ECO:0000303|PubMed:32633484, ECO:0000305|PubMed:32303640}.	generation of precursor metabolites and energy [GO:0006091]; glycolytic process [GO:0006096]; hematopoietic progenitor cell differentiation [GO:0002244]; tricarboxylic acid cycle [GO:0006099]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976]; generation of precursor metabolites and energy [GO:0006091]; glycolytic process [GO:0006096]; hematopoietic progenitor cell differentiation [GO:0002244]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23141294}.
Q96HZ4	reviewed	HES6_HUMAN	Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6)	HES6 BHLHB41	Homo sapiens (Human)	224	FUNCTION: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). {ECO:0000250}.		anterior/posterior pattern specification [GO:0009952]; cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; nervous system development [GO:0007399]; regulation of DNA-templated transcription [GO:0006355]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; nervous system development [GO:0007399]; regulation of DNA-templated transcription [GO:0006355]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96I15	reviewed	SCLY_HUMAN	Selenocysteine lyase (hSCL) (EC 4.4.1.16)	SCLY SCL	Homo sapiens (Human)	445	FUNCTION: Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. {ECO:0000250|UniProtKB:Q68FT9}.		amino acid metabolic process [GO:0006520]; selenocysteine catabolic process [GO:0016261]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]	amino acid binding [GO:0016597]; protein homodimerization activity [GO:0042803]; selenocysteine lyase activity [GO:0009000]; transferase activity [GO:0016740]; vitamin B6 binding [GO:0070279]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; amino acid binding [GO:0016597]; protein homodimerization activity [GO:0042803]; selenocysteine lyase activity [GO:0009000]; transferase activity [GO:0016740]; vitamin B6 binding [GO:0070279]; amino acid metabolic process [GO:0006520]; selenocysteine catabolic process [GO:0016261]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JLI6}.
Q96I23	reviewed	PREY_HUMAN	Protein preY, mitochondrial (PIGY upstream reading frame protein)	PYURF NDUFAFQ PREY	Homo sapiens (Human)	114	FUNCTION: In mitochondria, S-adenosylmethionine-dependent methyltransferase chaperone that supports both coenzyme Q biosynthesis, by stabilizing its components, such as COQ5, and NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) assembly, by stabilizing complex I assembly factors, such as NDUFAF5. {ECO:0000269|PubMed:35614220}.	MISCELLANEOUS: PREY and PIGY, 2 apparently unrelated proteins, are respectively the product of an upstream and a downstream ORF contained in a single bicistronic transcript.	protein stabilization [GO:0050821]	endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]		endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:35614220}.
Q96I24	reviewed	FUBP3_HUMAN	Far upstream element-binding protein 3 (FUSE-binding protein 3)	FUBP3 FBP3	Homo sapiens (Human)	572	FUNCTION: May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.		DNA-templated transcription [GO:0006351]; intracellular mRNA localization [GO:0008298]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; DNA-templated transcription [GO:0006351]; intracellular mRNA localization [GO:0008298]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96I25	reviewed	SPF45_HUMAN	Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17)	RBM17 SPF45	Homo sapiens (Human)	401	FUNCTION: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}.		alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA cis splicing, via spliceosome [GO:0045292]	nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA cis splicing, via spliceosome [GO:0045292]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9731529}.
Q96I27	reviewed	ZN625_HUMAN	Zinc finger protein 625	ZNF625	Homo sapiens (Human)	306	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96I34	reviewed	PP16A_HUMAN	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3)	PPP1R16A MYPT3	Homo sapiens (Human)	528	FUNCTION: Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. {ECO:0000250}.			cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Q96I51	reviewed	RCC1L_HUMAN	RCC1-like G exchanging factor-like protein (RCC1-like) (Williams-Beuren syndrome chromosomal region 16 protein)	RCC1L WBSCR16	Homo sapiens (Human)	464	FUNCTION: Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (PubMed:27667664). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:28746876}.		mitochondrial fusion [GO:0008053]; positive regulation of mitochondrial translation [GO:0070131]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]	GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; mitochondrial fusion [GO:0008053]; positive regulation of mitochondrial translation [GO:0070131]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:28608466, ECO:0000269|PubMed:28746876}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9CYF5}.
Q96I59	reviewed	SYNM_HUMAN	Probable asparagine--tRNA ligase, mitochondrial (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS)	NARS2	Homo sapiens (Human)	477			asparaginyl-tRNA aminoacylation [GO:0006421]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]; asparaginyl-tRNA aminoacylation [GO:0006421]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}. Mitochondrion {ECO:0000269|PubMed:25807530, ECO:0000269|PubMed:35558980}.
Q96I76	reviewed	GPTC3_HUMAN	G patch domain-containing protein 3	GPATCH3 GPATC3	Homo sapiens (Human)	525	FUNCTION: Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860). Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768). {ECO:0000269|PubMed:28397860, ECO:0000269|PubMed:28414768}.		negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; positive regulation of DNA-templated transcription [GO:0045893]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; positive regulation of DNA-templated transcription [GO:0045893]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28397860}. Cytoplasm {ECO:0000269|PubMed:28397860}.
Q96I99	reviewed	SUCB2_HUMAN	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG)	SUCLG2	Homo sapiens (Human)	432	FUNCTION: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. {ECO:0000255|HAMAP-Rule:MF_03221}.		succinate metabolic process [GO:0006105]; succinyl-CoA catabolic process [GO:1901289]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; succinate-CoA ligase complex [GO:0042709]; succinate-CoA ligase complex (GDP-forming) [GO:0045244]	ATP binding [GO:0005524]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; protein-containing complex binding [GO:0044877]; succinate-CoA ligase (GDP-forming) activity [GO:0004776]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; succinate-CoA ligase complex [GO:0042709]; succinate-CoA ligase complex (GDP-forming) [GO:0045244]; ATP binding [GO:0005524]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; protein-containing complex binding [GO:0044877]; succinate-CoA ligase (GDP-forming) activity [GO:0004776]; succinate metabolic process [GO:0006105]; succinyl-CoA catabolic process [GO:1901289]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03221}.
Q96IF1	reviewed	AJUBA_HUMAN	LIM domain-containing protein ajuba	AJUBA JUB	Homo sapiens (Human)	538	FUNCTION: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}.	MISCELLANEOUS: 'Ajuba' means 'curiosity' in Urdu, an Indian dialect.	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; canonical NF-kappaB signal transduction [GO:0007249]; cell cycle [GO:0007049]; cytoskeleton organization [GO:0007010]; focal adhesion assembly [GO:0048041]; glycerophospholipid biosynthetic process [GO:0046474]; lamellipodium assembly [GO:0030032]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of hippo signaling [GO:0035331]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cellular biosynthetic process [GO:0031328]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization [GO:0008104]; regulation of cell migration [GO:0030334]; regulation of cellular response to hypoxia [GO:1900037]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]; wound healing, spreading of epidermal cells [GO:0035313]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]	actin filament binding [GO:0051015]; alpha-catenin binding [GO:0045294]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]; actin filament binding [GO:0051015]; alpha-catenin binding [GO:0045294]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; canonical NF-kappaB signal transduction [GO:0007249]; cell cycle [GO:0007049]; cytoskeleton organization [GO:0007010]; focal adhesion assembly [GO:0048041]; glycerophospholipid biosynthetic process [GO:0046474]; lamellipodium assembly [GO:0030032]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of hippo signaling [GO:0035331]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cellular biosynthetic process [GO:0031328]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization [GO:0008104]; regulation of cell migration [GO:0030334]; regulation of cellular response to hypoxia [GO:1900037]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, P-body. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus.
Q96II8	reviewed	LRCH3_HUMAN	DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3)	LRCH3	Homo sapiens (Human)	777	FUNCTION: As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}.		septin cytoskeleton organization [GO:0032185]	cytoplasm [GO:0005737]; cytosol [GO:0005829]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; septin cytoskeleton organization [GO:0032185]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:29467281}.
Q96IJ6	reviewed	GMPPA_HUMAN	Mannose-1-phosphate guanyltransferase alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha)	GMPPA	Homo sapiens (Human)	420	FUNCTION: May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. {ECO:0000269|PubMed:24035193}.		biosynthetic process [GO:0009058]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	transferase activity [GO:0016740]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; transferase activity [GO:0016740]; biosynthetic process [GO:0009058]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24035193}. Note=Myc-tagged GMPPA shows a diffuse cytoplasmic and nuclear pattern in transfected COS-7 cells.
Q96IK1	reviewed	BOD1_HUMAN	Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B)	BOD1 FAM44B	Homo sapiens (Human)	185	FUNCTION: Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. {ECO:0000269|PubMed:17938248}.		cell division [GO:0051301]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid biorientation [GO:1990758]; mitotic sister chromatid cohesion, centromeric [GO:0071962]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; protein localization to chromosome, centromeric region [GO:0071459]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; outer kinetochore [GO:0000940]; Set1C/COMPASS complex [GO:0048188]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]	protein phosphatase 2A binding [GO:0051721]; protein phosphatase inhibitor activity [GO:0004864]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; outer kinetochore [GO:0000940]; Set1C/COMPASS complex [GO:0048188]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase inhibitor activity [GO:0004864]; cell division [GO:0051301]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid biorientation [GO:1990758]; mitotic sister chromatid cohesion, centromeric [GO:0071962]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; protein localization to chromosome, centromeric region [GO:0071459]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17938248}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17938248}. Note=Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.
Q96IK5	reviewed	GMCL1_HUMAN	Germ cell-less protein-like 1 (Spermatogenesis-associated protein 29)	GMCL1 BTBD13 GCL SPATA29	Homo sapiens (Human)	515	FUNCTION: Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). {ECO:0000250}.		germ cell development [GO:0007281]; spermatogenesis [GO:0007283]	nuclear matrix [GO:0016363]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	nuclear matrix [GO:0016363]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; germ cell development [GO:0007281]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250}.
Q96IL0	reviewed	COA8_HUMAN	Cytochrome c oxidase assembly factor 8 (COA8) (Apoptogenic protein 1, mitochondrial) (APOP-1)	COA8 APOP1 APOPT1 C14orf153	Homo sapiens (Human)	206	FUNCTION: Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain. {ECO:0000269|PubMed:25175347, ECO:0000269|PubMed:30552096}.	MISCELLANEOUS: [Isoform 2]: Protein may not fold correctly and may be rapidly degraded. {ECO:0000303|PubMed:30552096}.	intrinsic apoptotic signaling pathway [GO:0097193]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; positive regulation of cytochrome-c oxidase activity [GO:1904960]; protein stabilization [GO:0050821]; response to reactive oxygen species [GO:0000302]	matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrion [GO:0005739]		matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrion [GO:0005739]; intrinsic apoptotic signaling pathway [GO:0097193]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; positive regulation of cytochrome-c oxidase activity [GO:1904960]; protein stabilization [GO:0050821]; response to reactive oxygen species [GO:0000302]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:25175347, ECO:0000269|PubMed:30552096}; Peripheral membrane protein {ECO:0000305|PubMed:30552096}; Matrix side {ECO:0000269|PubMed:30552096}.
Q96IP4	reviewed	TET5A_HUMAN	Terminal nucleotidyltransferase 5A (EC 2.7.7.19) (HBV X-transactivated gene 11 protein) (HBV XAg-transactivated protein 11)	TENT5A C6orf37 FAM46A XTP11	Homo sapiens (Human)	442	FUNCTION: Cytoplasmic non-canonical poly(A) RNA polymerase that catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and participates in the cytoplasmic polyadenylation (PubMed:33882302). Polyadenylates mRNA encoding extracellular matrix constituents and other genes crucial for bone mineralization and during osteoblast mineralization, mainly focuses on ER-targeted mRNAs (By similarity). {ECO:0000250|UniProtKB:D3Z5S8, ECO:0000269|PubMed:33882302}.		mRNA stabilization [GO:0048255]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of ossification [GO:0030278]; response to bacterium [GO:0009617]	cytoplasm [GO:0005737]	poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; mRNA stabilization [GO:0048255]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of ossification [GO:0030278]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:D3Z5S8}.
Q96IQ9	reviewed	ZN414_HUMAN	Zinc finger protein 414	ZNF414	Homo sapiens (Human)	312	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96IR7	reviewed	HPDL_HUMAN	4-hydroxyphenylpyruvate dioxygenase-like protein (HPD-like protein) (EC 1.13.-.-) (Glyoxalase domain-containing protein 1)	HPDL GLOXD1	Homo sapiens (Human)	371	FUNCTION: May have dioxygenase activity. {ECO:0000305}.		aromatic amino acid metabolic process [GO:0009072]	mitochondrion [GO:0005739]	4-hydroxyphenylpyruvate dioxygenase activity [GO:0003868]; metal ion binding [GO:0046872]	mitochondrion [GO:0005739]; 4-hydroxyphenylpyruvate dioxygenase activity [GO:0003868]; metal ion binding [GO:0046872]; aromatic amino acid metabolic process [GO:0009072]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:32707086}.
Q96IS3	reviewed	RAX2_HUMAN	Retina and anterior neural fold homeobox protein 2 (Q50-type retinal homeobox protein) (Retina and anterior neural fold homeobox-like protein 1)	RAX2 QRX RAXL1	Homo sapiens (Human)	184	FUNCTION: May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter. {ECO:0000269|PubMed:15028672}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q96IT1	reviewed	ZN496_HUMAN	Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17)	ZNF496 ZKSCAN17	Homo sapiens (Human)	587	FUNCTION: DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}.		positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q96IU2	reviewed	ZBED3_HUMAN	Zinc finger BED domain-containing protein 3 (Axin-interacting protein)	ZBED3	Homo sapiens (Human)	234	FUNCTION: Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin (By similarity). Involved in transcription activation of Wnt target gene expression (By similarity). Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network (By similarity). Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation (By similarity). {ECO:0000250|UniProtKB:Q9D0L1}.		actin filament organization [GO:0007015]; endoplasmic reticulum localization [GO:0051643]; establishment of spindle localization [GO:0051293]; mitochondrion localization [GO:0051646]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of embryonic development [GO:0040019]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; actin filament organization [GO:0007015]; endoplasmic reticulum localization [GO:0051643]; establishment of spindle localization [GO:0051293]; mitochondrion localization [GO:0051646]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of embryonic development [GO:0040019]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D0L1}. Membrane {ECO:0000250|UniProtKB:Q9D0L1}. Secreted {ECO:0000269|PubMed:24283382}.
Q96IU4	reviewed	ABHEB_HUMAN	Putative protein-lysine deacylase ABHD14B (EC 2.3.1.-) (Alpha/beta hydrolase domain-containing protein 14B) (Abhydrolase domain-containing protein 14B) (CCG1-interacting factor B)	ABHD14B CIB	Homo sapiens (Human)	210	FUNCTION: Acts as an atypical protein-lysine deacetylase in vitro (PubMed:31478652). Catalyzes the deacetylation of lysine residues using CoA as substrate, generating acetyl-CoA and the free amine of protein-lysine residues (PubMed:31478652). Additional experiments are however required to confirm the protein-lysine deacetylase activity in vivo (Probable). Has hydrolase activity towards various surrogate p-nitrophenyl (pNp) substrates, such as pNp-butyrate, pNp-acetate and pNp-octanoate in vitro, with a strong preference for pNp-acetate (PubMed:31478652, PubMed:14672934). May activate transcription (PubMed:14672934). {ECO:0000269|PubMed:14672934, ECO:0000269|PubMed:31478652, ECO:0000305}.		3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	hydrolase activity [GO:0016787]; peptide-lysine-N-acetyltransferase activity [GO:0061733]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; hydrolase activity [GO:0016787]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11053859, ECO:0000269|PubMed:14672934, ECO:0000269|PubMed:31478652}. Nucleus {ECO:0000269|PubMed:11053859, ECO:0000269|PubMed:14672934, ECO:0000269|PubMed:31478652}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:14672934}.
Q96IV0	reviewed	NGLY1_HUMAN	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (hPNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase)	NGLY1 PNG1	Homo sapiens (Human)	654	FUNCTION: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. {ECO:0000269|PubMed:14749736, ECO:0000269|PubMed:15358861}.	MISCELLANEOUS: In case of infection by cytomegaloviruses, it is not essential for degradation of MHC class I heavy chains.	ER-associated misfolded protein catabolic process [GO:0071712]; glycoprotein catabolic process [GO:0006516]; protein deglycosylation [GO:0006517]; protein folding [GO:0006457]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [GO:0000224]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [GO:0000224]; ER-associated misfolded protein catabolic process [GO:0071712]; glycoprotein catabolic process [GO:0006516]; protein deglycosylation [GO:0006517]; protein folding [GO:0006457]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15358861}.
Q96IV6	reviewed	FXDC2_HUMAN	Fatty acid hydroxylase domain-containing protein 2	FAXDC2 C5orf4	Homo sapiens (Human)	333	FUNCTION: Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. {ECO:0000269|PubMed:27689744}.		positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of protein phosphorylation [GO:0001934]; sterol biosynthetic process [GO:0016126]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	C-4 methylsterol oxidase activity [GO:0000254]; iron ion binding [GO:0005506]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; C-4 methylsterol oxidase activity [GO:0000254]; iron ion binding [GO:0005506]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of protein phosphorylation [GO:0001934]; sterol biosynthetic process [GO:0016126]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27689744}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q96IW7	reviewed	SC22A_HUMAN	Vesicle-trafficking protein SEC22a (SEC22 vesicle-trafficking protein homolog A) (SEC22 vesicle-trafficking protein-like 2)	SEC22A SEC22L2	Homo sapiens (Human)	307	FUNCTION: May be involved in vesicle transport between the ER and the Golgi complex. {ECO:0000250|UniProtKB:Q642F4}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]	endoplasmic reticulum membrane [GO:0005789]	SNAP receptor activity [GO:0005484]	endoplasmic reticulum membrane [GO:0005789]; SNAP receptor activity [GO:0005484]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q96IX5	reviewed	ATPMK_HUMAN	ATP synthase membrane subunit K, mitochondrial (ATP synthase membrane subunit DAPIT, mitochondrial) (Diabetes-associated protein in insulin-sensitive tissues) (HCV F-transactivated protein 2) (Up-regulated during skeletal muscle growth protein 5)	ATP5MK ATP5MD DAPIT HCVFTP2 USMG5 PD04912	Homo sapiens (Human)	58	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (PubMed:29917077). ATP5MK is a minor subunit of the mitochondrial membrane ATP synthase required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria (PubMed:21345788, PubMed:29917077). {ECO:0000269|PubMed:21345788, ECO:0000269|PubMed:29917077, ECO:0000303|PubMed:29917077}.		proton motive force-driven ATP synthesis [GO:0015986]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrion [GO:0005739]; proton motive force-driven ATP synthesis [GO:0015986]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:21345788, ECO:0000269|PubMed:29917077}; Single-pass membrane protein {ECO:0000255}.
Q96IY1	reviewed	NSL1_HUMAN	Kinetochore-associated protein NSL1 homolog	NSL1 C1orf48 DC31 DC8 MIS14	Homo sapiens (Human)	281	FUNCTION: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:16585270}.		attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]	cytosol [GO:0005829]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spindle pole [GO:0000922]		cytosol [GO:0005829]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spindle pole [GO:0000922]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. Note=Associated with the kinetochore (PubMed:15502821, PubMed:16585270).
Q96IY4	reviewed	CBPB2_HUMAN	Carboxypeptidase B2 (EC 3.4.17.20) (Carboxypeptidase U) (CPU) (Plasma carboxypeptidase B) (pCPB) (Thrombin-activable fibrinolysis inhibitor) (TAFI)	CPB2	Homo sapiens (Human)	423	FUNCTION: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. {ECO:0000269|PubMed:10574983}.		blood coagulation [GO:0007596]; cellular response to glucose stimulus [GO:0071333]; fibrinolysis [GO:0042730]; liver regeneration [GO:0097421]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of plasminogen activation [GO:0010757]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; response to xenobiotic stimulus [GO:0009410]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; blood coagulation [GO:0007596]; cellular response to glucose stimulus [GO:0071333]; fibrinolysis [GO:0042730]; liver regeneration [GO:0097421]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of plasminogen activation [GO:0010757]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Secreted.
Q96IZ0	reviewed	PAWR_HUMAN	PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4)	PAWR PAR4	Homo sapiens (Human)	340	FUNCTION: Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}.		actin filament bundle assembly [GO:0051017]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cellular senescence [GO:2000774]; positive regulation of gene expression [GO:0010628]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; enzyme binding [GO:0019899]; leucine zipper domain binding [GO:0043522]; transcription corepressor activity [GO:0003714]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; enzyme binding [GO:0019899]; leucine zipper domain binding [GO:0043522]; transcription corepressor activity [GO:0003714]; actin filament bundle assembly [GO:0051017]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cellular senescence [GO:2000774]; positive regulation of gene expression [GO:0010628]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. {ECO:0000250}.
Q96IZ2	reviewed	ADTRP_HUMAN	Androgen-dependent TFPI-regulating protein (Fatty acid esters of hydroxy fatty acids hydrolase ADTRP) (FAHFA hydrolase ADTRP) (EC 3.1.-.-)	ADTRP C6orf105	Homo sapiens (Human)	230	FUNCTION: Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574). {ECO:0000269|PubMed:21868574, ECO:0000269|PubMed:27018888}.		cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to steroid hormone stimulus [GO:0071383]; long-chain fatty acid catabolic process [GO:0042758]; negative regulation of blood coagulation [GO:0030195]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of protein secretion [GO:0050709]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]	caveola [GO:0005901]; cell surface [GO:0009986]; endomembrane system [GO:0012505]; membrane [GO:0016020]	hydrolase activity [GO:0016787]	caveola [GO:0005901]; cell surface [GO:0009986]; endomembrane system [GO:0012505]; membrane [GO:0016020]; hydrolase activity [GO:0016787]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to steroid hormone stimulus [GO:0071383]; long-chain fatty acid catabolic process [GO:0042758]; negative regulation of blood coagulation [GO:0030195]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of protein secretion [GO:0050709]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21868574, ECO:0000269|PubMed:27018888}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with TFPI and CAV1 in lipid rafts. {ECO:0000269|PubMed:21868574}.
Q96IZ5	reviewed	RBM41_HUMAN	RNA-binding protein 41 (RNA-binding motif protein 41)	RBM41	Homo sapiens (Human)	413	FUNCTION: May bind RNA. {ECO:0000305}.		mRNA splicing, via spliceosome [GO:0000398]	U12-type spliceosomal complex [GO:0005689]	pre-mRNA intronic binding [GO:0097157]; U12 snRNA binding [GO:0030626]	U12-type spliceosomal complex [GO:0005689]; pre-mRNA intronic binding [GO:0097157]; U12 snRNA binding [GO:0030626]; mRNA splicing, via spliceosome [GO:0000398]	
Q96IZ6	reviewed	MET2A_HUMAN	tRNA N(3)-methylcytidine methyltransferase METTL2A (EC 2.1.1.-) (Methyltransferase-like protein 2A)	METTL2A METTL2 HSPC266	Homo sapiens (Human)	378	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557). {ECO:0000269|PubMed:28655767, ECO:0000269|PubMed:34268557}.		tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]	cytoplasm [GO:0005737]	tRNA (cytosine-3-)-methyltransferase activity [GO:0052735]	cytoplasm [GO:0005737]; tRNA (cytosine-3-)-methyltransferase activity [GO:0052735]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34268557}.
Q96IZ7	reviewed	RSRC1_HUMAN	Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1)	RSRC1 SRRP53 BM-011	Homo sapiens (Human)	334	FUNCTION: Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. {ECO:0000269|PubMed:15798186, ECO:0000269|PubMed:29522154}.		alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splicing, via spliceosome [GO:0000398]; nucleocytoplasmic transport [GO:0006913]; response to antibiotic [GO:0046677]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splicing, via spliceosome [GO:0000398]; nucleocytoplasmic transport [GO:0006913]; response to antibiotic [GO:0046677]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm. {ECO:0000250}.
Q96J01	reviewed	THOC3_HUMAN	THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45)	THOC3	Homo sapiens (Human)	351	FUNCTION: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867}.		mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; viral mRNA export from host cell nucleus [GO:0046784]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]	RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; viral mRNA export from host cell nucleus [GO:0046784]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Nucleus speckle {ECO:0000305}.
Q96J02	reviewed	ITCH_HUMAN	E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)	ITCH	Homo sapiens (Human)	903	FUNCTION: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14602072, PubMed:17028573, PubMed:16387660, PubMed:18718448, PubMed:18718449, PubMed:11046148, PubMed:19592251, PubMed:19116316, PubMed:19881509, PubMed:20491914, PubMed:20392206, PubMed:20068034, PubMed:23146885, PubMed:24790097, PubMed:25631046, PubMed:15051726). Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (PubMed:17028573, PubMed:18718448, PubMed:19131965, PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:19131965). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (PubMed:19131965). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (PubMed:19592251). Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response (PubMed:18718448, PubMed:20491914). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (PubMed:18718448). Mediates JUN ubiquitination and degradation (By similarity). Mediates JUNB ubiquitination and degradation (PubMed:16387660). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (By similarity). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (PubMed:19881509). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (PubMed:19881509). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (PubMed:23146885). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885, PubMed:34927784). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (PubMed:20068034). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Inhibits the replication of influenza A virus (IAV) via ubiquitination of IAV matrix protein 1 (M1) through 'Lys-48'-linked conjugation resulting in M1 proteasomal degradation (PubMed:30328013). Ubiquitinates NEDD9/HEF1, resulting in proteasomal degradation of NEDD9/HEF1 (PubMed:15051726). {ECO:0000250|UniProtKB:Q8C863, ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:15051726, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:17028573, ECO:0000269|PubMed:18628966, ECO:0000269|PubMed:18718448, ECO:0000269|PubMed:18718449, ECO:0000269|PubMed:19116316, ECO:0000269|PubMed:19131965, ECO:0000269|PubMed:19592251, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:20068034, ECO:0000269|PubMed:20392206, ECO:0000269|PubMed:20491914, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:23886940, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:30328013}.		apoptotic process [GO:0006915]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of defense response to virus [GO:0050687]; negative regulation of JNK cascade [GO:0046329]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of type I interferon production [GO:0032480]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of receptor catabolic process [GO:2000646]; positive regulation of T cell anergy [GO:0002669]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; receptor internalization [GO:0031623]; regulation of cell growth [GO:0001558]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of necroptotic process [GO:0060544]; regulation of protein deubiquitination [GO:0090085]; T cell anergy [GO:0002870]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral entry into host cell [GO:0046718]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	arrestin family protein binding [GO:1990763]; CXCR chemokine receptor binding [GO:0045236]; ligase activity [GO:0016874]; ribonucleoprotein complex binding [GO:0043021]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; arrestin family protein binding [GO:1990763]; CXCR chemokine receptor binding [GO:0045236]; ligase activity [GO:0016874]; ribonucleoprotein complex binding [GO:0043021]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of defense response to virus [GO:0050687]; negative regulation of JNK cascade [GO:0046329]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of type I interferon production [GO:0032480]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of receptor catabolic process [GO:2000646]; positive regulation of T cell anergy [GO:0002669]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; receptor internalization [GO:0031623]; regulation of cell growth [GO:0001558]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of necroptotic process [GO:0060544]; regulation of protein deubiquitination [GO:0090085]; T cell anergy [GO:0002870]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14602072}; Peripheral membrane protein {ECO:0000305|PubMed:14602072}; Cytoplasmic side {ECO:0000305|PubMed:14602072}. Cytoplasm {ECO:0000269|PubMed:14602072}. Nucleus {ECO:0000269|PubMed:20858735}. Early endosome membrane {ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:14602072, ECO:0000305|PubMed:23146885, ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:14602072, ECO:0000305|PubMed:23146885, ECO:0000305|PubMed:24790097}. Endosome membrane {ECO:0000269|PubMed:23146885}; Peripheral membrane protein {ECO:0000305|PubMed:23146885}; Cytoplasmic side {ECO:0000305|PubMed:23146885}. Note=May be recruited to exosomes by NDFIP1 (PubMed:18819914). Localizes to plasma membrane upon CXCL12 stimulation where it co-localizes with CXCL4 (PubMed:14602072). Localization to early endosomes is increased upon CXCL12 stimulation where it co-localizes with DTX3L and CXCL4 (PubMed:24790097). {ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:18819914, ECO:0000269|PubMed:24790097}.
Q96J42	reviewed	TXD15_HUMAN	Thioredoxin domain-containing protein 15	TXNDC15 C5orf14 UNQ335/PRO534	Homo sapiens (Human)	360	FUNCTION: Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Involved in ciliogenesis (PubMed:27894351). {ECO:0000250|UniProtKB:Q6P6J9, ECO:0000269|PubMed:27894351}.		cilium assembly [GO:0060271]; positive regulation of smoothened signaling pathway [GO:0045880]	ciliary membrane [GO:0060170]; cilium [GO:0005929]		ciliary membrane [GO:0060170]; cilium [GO:0005929]; cilium assembly [GO:0060271]; positive regulation of smoothened signaling pathway [GO:0045880]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q6P6J9}; Single-pass type I membrane protein {ECO:0000255}.
Q96J65	reviewed	MRP9_HUMAN	ATP-binding cassette sub-family C member 12 (Multidrug resistance-associated protein 9)	ABCC12 MRP9	Homo sapiens (Human)	1359	FUNCTION: Probable transporter, its substrate specificity is unknown. {ECO:0000305|PubMed:17472575}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	transmembrane transport [GO:0055085]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17472575}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Q96J66	reviewed	MRP8_HUMAN	ATP-binding cassette sub-family C member 11 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 8)	ABCC11 MRP8	Homo sapiens (Human)	1382	FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Enhances also the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate (PubMed:25896536, PubMed:15537867, PubMed:12764137). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689, PubMed:12764137, PubMed:15537867, PubMed:16444273, PubMed:19383836, PubMed:25896536). {ECO:0000269|PubMed:12764137, ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16444273, ECO:0000269|PubMed:19383836, ECO:0000269|PubMed:19710689, ECO:0000269|PubMed:25896536}.	MISCELLANEOUS: This protein has no ortholog in rodents. {ECO:0000305}.	bile acid and bile salt transport [GO:0015721]; leukotriene transport [GO:0071716]; organic anion transport [GO:0015711]; purine nucleotide transport [GO:0015865]; transmembrane transport [GO:0055085]; xenobiotic transport [GO:0042908]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]	ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; organic anion transmembrane transporter activity [GO:0008514]; purine nucleotide transmembrane transporter activity [GO:0015216]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]; ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; organic anion transmembrane transporter activity [GO:0008514]; purine nucleotide transmembrane transporter activity [GO:0015216]; bile acid and bile salt transport [GO:0015721]; leukotriene transport [GO:0071716]; organic anion transport [GO:0015711]; purine nucleotide transport [GO:0015865]; transmembrane transport [GO:0055085]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19383836, ECO:0000269|PubMed:25896536}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000269|PubMed:19383836}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:25896536}. Apical cell membrane {ECO:0000269|PubMed:16359813}; Multi-pass membrane protein.
Q96J84	reviewed	KIRR1_HUMAN	Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)	KIRREL1 KIRREL NEPH1	Homo sapiens (Human)	757	FUNCTION: Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:31472902}.		cell-cell adhesion [GO:0098609]; cell-cell junction maintenance [GO:0045217]; glomerular filtration [GO:0003094]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of actin filament polymerization [GO:0030838]; renal protein absorption [GO:0097017]	cell-cell junction [GO:0005911]; dendritic shaft [GO:0043198]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cell adhesion molecule binding [GO:0050839]; myosin binding [GO:0017022]	cell-cell junction [GO:0005911]; dendritic shaft [GO:0043198]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; myosin binding [GO:0017022]; cell-cell adhesion [GO:0098609]; cell-cell junction maintenance [GO:0045217]; glomerular filtration [GO:0003094]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of actin filament polymerization [GO:0030838]; renal protein absorption [GO:0097017]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31472902}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm.
Q96J87	reviewed	CELF6_HUMAN	CUGBP Elav-like family member 6 (CELF-6) (Bruno-like protein 6) (CUG-BP- and ETR-3-like factor 6) (RNA-binding protein BRUNOL-6)	CELF6 BRUNOL6	Homo sapiens (Human)	481	FUNCTION: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA. {ECO:0000269|PubMed:14761971}.		mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q96J92	reviewed	WNK4_HUMAN	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4)	WNK4 PRKWNK4	Homo sapiens (Human)	1243	FUNCTION: Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhbits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250|UniProtKB:Q80UE6, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:22989884}.	MISCELLANEOUS: [Isoform 3]: Incomplete sequence. {ECO:0000305}.	aldosterone secretion [GO:0035932]; calcium ion homeostasis [GO:0055074]; cellular response to xenobiotic stimulus [GO:0071466]; chloride transport [GO:0006821]; distal tubule morphogenesis [GO:0072156]; ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; macrophage activation [GO:0042116]; monoatomic ion homeostasis [GO:0050801]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of sodium ion transport [GO:0010766]; potassium ion transmembrane transport [GO:0071805]; protein kinase C signaling [GO:0070528]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of potassium ion export across plasma membrane [GO:1903764]; renal sodium ion absorption [GO:0070294]; renal sodium ion transport [GO:0003096]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]	bicellular tight junction [GO:0005923]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; chloride ion binding [GO:0031404]; ion channel inhibitor activity [GO:0008200]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	bicellular tight junction [GO:0005923]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; chloride ion binding [GO:0031404]; ion channel inhibitor activity [GO:0008200]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; aldosterone secretion [GO:0035932]; calcium ion homeostasis [GO:0055074]; cellular response to xenobiotic stimulus [GO:0071466]; chloride transport [GO:0006821]; distal tubule morphogenesis [GO:0072156]; ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; macrophage activation [GO:0042116]; monoatomic ion homeostasis [GO:0050801]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of sodium ion transport [GO:0010766]; potassium ion transmembrane transport [GO:0071805]; protein kinase C signaling [GO:0070528]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of potassium ion export across plasma membrane [GO:1903764]; renal sodium ion absorption [GO:0070294]; renal sodium ion transport [GO:0003096]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:Q80UE6}. Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct (By similarity). WNK4 is part of the tight junction complex (By similarity). {ECO:0000250|UniProtKB:Q80UE6}.
Q96J94	reviewed	PIWL1_HUMAN	Piwi-like protein 1 (EC 3.1.26.-)	PIWIL1 HIWI	Homo sapiens (Human)	861	FUNCTION: Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability. Required to sequester RNF8 in the cytoplasm until late spermatogenesis; RNF8 being released upon ubiquitination and degradation of PIWIL1. {ECO:0000250|UniProtKB:Q9JMB7}.; FUNCTION: [Isoform 3]: May be a negative developmental regulator (PubMed:12037681, PubMed:16287078). {ECO:0000269|PubMed:12037681, ECO:0000269|PubMed:16287078}.		meiotic cell cycle [GO:0051321]; piRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141006]; primary piRNA processing [GO:0140990]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; dense body [GO:0097433]; nucleus [GO:0005634]; P granule [GO:0043186]	metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; mRNA cap binding complex binding [GO:0140262]; piRNA binding [GO:0034584]; polysome binding [GO:1905538]; protein kinase binding [GO:0019901]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; dense body [GO:0097433]; nucleus [GO:0005634]; P granule [GO:0043186]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; mRNA cap binding complex binding [GO:0140262]; piRNA binding [GO:0034584]; polysome binding [GO:1905538]; protein kinase binding [GO:0019901]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]; meiotic cell cycle [GO:0051321]; piRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141006]; primary piRNA processing [GO:0140990]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9JMB7}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body. {ECO:0000250|UniProtKB:Q9JMB7}.
Q96JA1	reviewed	LRIG1_HUMAN	Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1)	LRIG1 LIG1	Homo sapiens (Human)	1093	FUNCTION: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}.		hair cycle process [GO:0022405]; innervation [GO:0060384]; otolith morphogenesis [GO:0032474]; sensory perception of sound [GO:0007605]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; hair cycle process [GO:0022405]; innervation [GO:0060384]; otolith morphogenesis [GO:0032474]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15282549}; Single-pass type I membrane protein {ECO:0000305|PubMed:15282549}.
Q96JA3	reviewed	PKHA8_HUMAN	Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) (Phosphatidylinositol-four-phosphate adapter protein 2) (FAPP-2) (Phosphoinositol 4-phosphate adapter protein 2) (hFAPP2) (Serologically defined breast cancer antigen NY-BR-86)	PLEKHA8 FAPP2	Homo sapiens (Human)	519	FUNCTION: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. {ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:16103222, ECO:0000269|PubMed:17687330}.		ER to Golgi ceramide transport [GO:0035621]; intermembrane lipid transfer [GO:0120009]; lipid transport [GO:0006869]; protein transport [GO:0015031]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]	ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ceramide binding [GO:0097001]; glycolipid binding [GO:0051861]; glycolipid transfer activity [GO:0017089]; phosphatidylinositol-4-phosphate binding [GO:0070273]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]; ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ceramide binding [GO:0097001]; glycolipid binding [GO:0051861]; glycolipid transfer activity [GO:0017089]; phosphatidylinositol-4-phosphate binding [GO:0070273]; ER to Golgi ceramide transport [GO:0035621]; intermembrane lipid transfer [GO:0120009]; lipid transport [GO:0006869]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15107860}. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:15107860}. Note=Binds through its PH domain to PtdIns(4)P and ARF1, and subsequently localizes to TGN exit sites. {ECO:0000269|PubMed:15107860}.
Q96JB1	reviewed	DYH8_HUMAN	Dynein axonemal heavy chain 8 (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8)	DNAH8	Homo sapiens (Human)	4490	FUNCTION: Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. {ECO:0000269|PubMed:32619401}.		cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; outer dynein arm assembly [GO:0036158]	axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]	axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]; cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; outer dynein arm assembly [GO:0036158]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:31178125, ECO:0000269|PubMed:32619401}. Cytoplasm {ECO:0000250|UniProtKB:Q91XQ0}. Note=Detected in sperm tail, with almost exclusive localization to the principal piece. Also detected in the cytoplasm of primary spermatocytes. {ECO:0000250|UniProtKB:Q91XQ0}.
Q96JB2	reviewed	COG3_HUMAN	Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94)	COG3 SEC34	Homo sapiens (Human)	828	FUNCTION: Involved in ER-Golgi transport. {ECO:0000269|PubMed:11929878}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; protein glycosylation [GO:0006486]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]		cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; protein glycosylation [GO:0006486]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:11292827}; Peripheral membrane protein {ECO:0000269|PubMed:11292827}. Note=Associated with the peripheral membrane of cis/medial cisternae.
Q96JB3	reviewed	HIC2_HUMAN	Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30)	HIC2 HRG22 KIAA1020 ZBTB30	Homo sapiens (Human)	615	FUNCTION: Transcriptional repressor.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus.
Q96JB5	reviewed	CK5P3_HUMAN	CDK5 regulatory subunit-associated protein 3 (CDK5 activator-binding protein C53) (LXXLL/leucine-zipper-containing ARF-binding protein) (Protein HSF-27)	CDK5RAP3 IC53 LZAP MSTP016 OK/SW-cl.114 PP1553	Homo sapiens (Human)	506	FUNCTION: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (PubMed:23152784, PubMed:30635284). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). Required for liver development (By similarity). {ECO:0000250|UniProtKB:Q99LM2, ECO:0000269|PubMed:12054757, ECO:0000269|PubMed:12737517, ECO:0000269|PubMed:15790566, ECO:0000269|PubMed:16173922, ECO:0000269|PubMed:17785205, ECO:0000269|PubMed:19223857, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:21283629, ECO:0000269|PubMed:23152784, ECO:0000269|PubMed:23478299, ECO:0000269|PubMed:30635284}.; FUNCTION: (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry. {ECO:0000269|PubMed:21971960}.	MISCELLANEOUS: [Isoform 2]: Due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Due to intron retention. {ECO:0000305}.	apoptotic nuclear changes [GO:0030262]; brain development [GO:0007420]; cell population proliferation [GO:0008283]; definitive erythrocyte differentiation [GO:0060318]; endoplasmic reticulum unfolded protein response [GO:0030968]; liver development [GO:0001889]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ufmylation [GO:0071569]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic cell cycle [GO:0007346]; regulation of neuron differentiation [GO:0045664]; regulation of phosphatase activity [GO:0010921]; response to endoplasmic reticulum stress [GO:0034976]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	cyclin binding [GO:0030332]; MDM2/MDM4 family protein binding [GO:0097371]; mitogen-activated protein kinase binding [GO:0051019]; NF-kappaB binding [GO:0051059]; protein kinase binding [GO:0019901]; ubiquitin-like protein ligase binding [GO:0044389]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; cyclin binding [GO:0030332]; MDM2/MDM4 family protein binding [GO:0097371]; mitogen-activated protein kinase binding [GO:0051019]; NF-kappaB binding [GO:0051059]; protein kinase binding [GO:0019901]; ubiquitin-like protein ligase binding [GO:0044389]; apoptotic nuclear changes [GO:0030262]; brain development [GO:0007420]; cell population proliferation [GO:0008283]; definitive erythrocyte differentiation [GO:0060318]; endoplasmic reticulum unfolded protein response [GO:0030968]; liver development [GO:0001889]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ufmylation [GO:0071569]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic cell cycle [GO:0007346]; regulation of neuron differentiation [GO:0045664]; regulation of phosphatase activity [GO:0010921]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16173922}. Cytoplasm {ECO:0000269|PubMed:15790566, ECO:0000269|PubMed:16173922, ECO:0000269|PubMed:19223857}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19223857}. Note=Colocalizes and associates with microtubules. {ECO:0000269|PubMed:23478299}.
Q96JB6	reviewed	LOXL4_HUMAN	Lysyl oxidase homolog 4 (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C)	LOXL4 LOXC	Homo sapiens (Human)	756	FUNCTION: May modulate the formation of a collagenous extracellular matrix.		collagen fibril organization [GO:0030199]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; receptor complex [GO:0043235]	copper ion binding [GO:0005507]; protein-lysine 6-oxidase activity [GO:0004720]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; receptor complex [GO:0043235]; copper ion binding [GO:0005507]; protein-lysine 6-oxidase activity [GO:0004720]; collagen fibril organization [GO:0030199]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000305}.
Q96JB8	reviewed	MPP4_HUMAN	MAGUK p55 subfamily member 4 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein) (Discs large homolog 6)	MPP4 ALS2CR5 DLG6	Homo sapiens (Human)	637	FUNCTION: May play a role in retinal photoreceptors development. {ECO:0000250}.		protein localization to synapse [GO:0035418]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]		actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; protein localization to synapse [GO:0035418]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15914641}. Note=Detected at the outer limiting membrane (OLM) and in the outer plexiform layer (OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ).
Q96JC1	reviewed	VPS39_HUMAN	Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p)	VPS39 KIAA0770 TLP VAM6	Homo sapiens (Human)	886	FUNCTION: Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. {ECO:0000269|PubMed:12941698}.; FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (PubMed:11448994, PubMed:23351085, PubMed:23167963). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:23167963, ECO:0000269|PubMed:25783203, ECO:0000269|PubMed:33422265, ECO:0000305|PubMed:23351085}.		autophagosome-lysosome fusion [GO:0061909]; autophagy [GO:0006914]; endocytic recycling [GO:0032456]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; late endosome to lysosome transport [GO:1902774]; regulation of SNARE complex assembly [GO:0035542]	AP-3 adaptor complex [GO:0030123]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal HOPS complex [GO:1902501]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]		AP-3 adaptor complex [GO:0030123]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal HOPS complex [GO:1902501]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; autophagosome-lysosome fusion [GO:0061909]; autophagy [GO:0006914]; endocytic recycling [GO:0032456]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; late endosome to lysosome transport [GO:1902774]; regulation of SNARE complex assembly [GO:0035542]	SUBCELLULAR LOCATION: Cytoplasm. Lysosome membrane {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:23167963}; Peripheral membrane protein {ECO:0000305|PubMed:11448994}. Late endosome membrane {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:23167963}; Peripheral membrane protein {ECO:0000305|PubMed:11448994}. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles. {ECO:0000269|PubMed:12941698}.; SUBCELLULAR LOCATION: Note=(Microbial infection) Sequestrated at the late endosome by SARS coronavirus-2/SARS-CoV-2 ORF3A protein. {ECO:0000269|PubMed:33422265}.
Q96JC9	reviewed	EAF1_HUMAN	ELL-associated factor 1	EAF1	Homo sapiens (Human)	268	FUNCTION: Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. {ECO:0000269|PubMed:11418481, ECO:0000269|PubMed:16006523}.		regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368]	Cajal body [GO:0015030]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023]	transcription elongation factor activity [GO:0003711]	Cajal body [GO:0015030]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023]; transcription elongation factor activity [GO:0003711]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11418481}. Nucleus, Cajal body {ECO:0000269|PubMed:12686606}.
Q96JD6	reviewed	AKCL2_HUMAN	1,5-anhydro-D-fructose reductase (AF reductase) (EC 1.1.1.263) (Aldo-keto reductase family 1 member C-like protein 2) (Aldo-keto reductase family 1 member E2) (LoopADR) (Testis aldo-keto reductase) (htAKR) (Testis-specific protein) (hTSP)	AKR1E2 AKR1CL2 AKRDC1	Homo sapiens (Human)	320	FUNCTION: Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078). {ECO:0000250|UniProtKB:Q9DCT1, ECO:0000269|PubMed:12604216, ECO:0000269|PubMed:15118078}.			cytosol [GO:0005829]	1,5-anhydro-D-fructose reductase activity [GO:0050571]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; oxidoreductase activity [GO:0016491]	cytosol [GO:0005829]; 1,5-anhydro-D-fructose reductase activity [GO:0050571]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; oxidoreductase activity [GO:0016491]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q96JE7	reviewed	SC16B_HUMAN	Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B)	SEC16B KIAA1928 LZTR2 RGPR SEC16S	Homo sapiens (Human)	1060	FUNCTION: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:21768384, PubMed:22355596). Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes (PubMed:21768384). {ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:21768384, ECO:0000303|PubMed:22355596}.		autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; peroxisome fission [GO:0016559]; peroxisome organization [GO:0007031]; positive regulation of gene expression [GO:0010628]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein transport [GO:0015031]	cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]		cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; peroxisome fission [GO:0016559]; peroxisome organization [GO:0007031]; positive regulation of gene expression [GO:0010628]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21768384}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). {ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596}.
Q96JE9	reviewed	MAP6_HUMAN	Microtubule-associated protein 6 (MAP-6) (Stable tubule-only polypeptide) (STOP)	MAP6 KIAA1878	Homo sapiens (Human)	813	FUNCTION: Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity). {ECO:0000250|UniProtKB:Q63560, ECO:0000269|PubMed:24357581}.		cytoskeleton-dependent intracellular transport [GO:0030705]; dendrite morphogenesis [GO:0048813]; lysosome localization [GO:0032418]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of axonogenesis [GO:0050772]; regulation of microtubule cytoskeleton organization [GO:0070507]	axon [GO:0030424]; cis-Golgi network [GO:0005801]; dendrite [GO:0030425]; Golgi-associated vesicle [GO:0005798]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle membrane [GO:0030658]	calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]	axon [GO:0030424]; cis-Golgi network [GO:0005801]; dendrite [GO:0030425]; Golgi-associated vesicle [GO:0005798]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle membrane [GO:0030658]; calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]; cytoskeleton-dependent intracellular transport [GO:0030705]; dendrite morphogenesis [GO:0048813]; lysosome localization [GO:0032418]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of axonogenesis [GO:0050772]; regulation of microtubule cytoskeleton organization [GO:0070507]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14692697}. Golgi apparatus {ECO:0000250|UniProtKB:Q63560}. Cell projection, axon {ECO:0000250|UniProtKB:Q63560}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63560}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q63560}; Lipid-anchor {ECO:0000250|UniProtKB:Q63560}; Cytoplasmic side {ECO:0000250|UniProtKB:Q63560}. Note=Localizes predominantly in the proximal part of the axon (By similarity). Preferentially is concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (By similarity). In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of neurites (By similarity). Following neuronal polarization and during axon outgrowth, accumulates in the axonal growth cone and subsequently localizes throughout the axon (By similarity). Partially localizes to dendrites in mature neurons (By similarity). Colocalizes with neurofilament (NF)-rich inclusions in spinal cord and brain neurons of patients with amyotrophic lateral sclerosis (ALS) (PubMed:14692697). {ECO:0000250|UniProtKB:Q63560, ECO:0000269|PubMed:14692697}.
Q96JF0	reviewed	SIAT2_HUMAN	Beta-galactoside alpha-2,6-sialyltransferase 2 (Alpha 2,6-ST 2) (EC 2.4.3.1) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2) (ST6Gal II) (ST6GalII) (hST6Gal II) (Sialyltransferase 2)	ST6GAL2 KIAA1877 SIAT2	Homo sapiens (Human)	529	FUNCTION: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids. {ECO:0000269|PubMed:12235148}.		oligosaccharide metabolic process [GO:0009311]; sialylation [GO:0097503]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	beta-galactoside alpha-2,6-sialyltransferase activity [GO:0003835]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; beta-galactoside alpha-2,6-sialyltransferase activity [GO:0003835]; oligosaccharide metabolic process [GO:0009311]; sialylation [GO:0097503]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q96JG6	reviewed	VPS50_HUMAN	Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50)	VPS50 CCDC132 KIAA1861	Homo sapiens (Human)	964	FUNCTION: Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:25799061}.	MISCELLANEOUS: Was named 'syndetin' after the Greek 'syndeo', which means 'connect' or 'tether'. {ECO:0000303|PubMed:25799061}.	endocytic recycling [GO:0032456]; protein transport [GO:0015031]	EARP complex [GO:1990745]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]	SNARE binding [GO:0000149]	EARP complex [GO:1990745]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; SNARE binding [GO:0000149]; endocytic recycling [GO:0032456]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Recycling endosome {ECO:0000269|PubMed:25799061}. Membrane {ECO:0000250|UniProtKB:F1LSG8}. Note=Associates with membranes in an EIPR1-dependent manner. {ECO:0000250|UniProtKB:F1LSG8}.
Q96JG8	reviewed	MAGD4_HUMAN	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen)	MAGED4 KIAA1859 MAGED4A MAGEE1; MAGED4B	Homo sapiens (Human)	741	FUNCTION: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
Q96JG9	reviewed	ZN469_HUMAN	Zinc finger protein 469	ZNF469 KIAA1858	Homo sapiens (Human)	3925	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of extracellular matrix organization [GO:1903053]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of extracellular matrix organization [GO:1903053]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96JH7	reviewed	VCIP1_HUMAN	Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein)	VCPIP1 KIAA1850 VCIP135	Homo sapiens (Human)	1222	FUNCTION: Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}.		DNA damage response [GO:0006974]; endoplasmic reticulum membrane fusion [GO:0016320]; Golgi reassembly [GO:0090168]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; regulation of protein localization to chromatin [GO:1905634]	cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; Golgi stack [GO:0005795]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; Golgi stack [GO:0005795]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; DNA damage response [GO:0006974]; endoplasmic reticulum membrane fusion [GO:0016320]; Golgi reassembly [GO:0090168]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; regulation of protein localization to chromatin [GO:1905634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32649882}. Cytoplasm {ECO:0000269|PubMed:32649882}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8CF97}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:Q8CF97}. Note=Associated with Golgi stacks and endoplasmic reticulum (By similarity). Displays cytoplasmic to nuclear translocation in response to DNA-protein cross-links (DPCs)-inducing agents (PubMed:32649882). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:32649882}.
Q96JH8	reviewed	RADIL_HUMAN	Ras-associating and dilute domain-containing protein	RADIL KIAA1849	Homo sapiens (Human)	1075	FUNCTION: Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}.		neural crest cell migration [GO:0001755]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]	microtubule [GO:0005874]; protein-containing complex [GO:0032991]	GTPase binding [GO:0051020]	microtubule [GO:0005874]; protein-containing complex [GO:0032991]; GTPase binding [GO:0051020]; neural crest cell migration [GO:0001755]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]	
Q96JI7	reviewed	SPTCS_HUMAN	Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein)	SPG11 KIAA1840	Homo sapiens (Human)	2443	FUNCTION: May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. {ECO:0000269|PubMed:24794856}.		autophagosome organization [GO:1905037]; axo-dendritic transport [GO:0008088]; axon extension [GO:0048675]; chemical synaptic transmission [GO:0007268]; cholesterol efflux [GO:0033344]; corticospinal tract morphogenesis [GO:0021957]; localization within membrane [GO:0051668]; lysosome organization [GO:0007040]; memory [GO:0007613]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; neuromuscular junction development [GO:0007528]; phagosome-lysosome fusion involved in apoptotic cell clearance [GO:0090389]; protein import into nucleus [GO:0006606]; regulation of store-operated calcium entry [GO:2001256]; skeletal muscle fiber development [GO:0048741]; synaptic vesicle transport [GO:0048489]; walking behavior [GO:0090659]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; lysosomal membrane [GO:0005765]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; synapse [GO:0045202]	protein kinase binding [GO:0019901]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; lysosomal membrane [GO:0005765]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; synapse [GO:0045202]; protein kinase binding [GO:0019901]; autophagosome organization [GO:1905037]; axo-dendritic transport [GO:0008088]; axon extension [GO:0048675]; chemical synaptic transmission [GO:0007268]; cholesterol efflux [GO:0033344]; corticospinal tract morphogenesis [GO:0021957]; localization within membrane [GO:0051668]; lysosome organization [GO:0007040]; memory [GO:0007613]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; neuromuscular junction development [GO:0007528]; phagosome-lysosome fusion involved in apoptotic cell clearance [GO:0090389]; protein import into nucleus [GO:0006606]; regulation of store-operated calcium entry [GO:2001256]; skeletal muscle fiber development [GO:0048741]; synaptic vesicle transport [GO:0048489]; walking behavior [GO:0090659]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17322883}. Nucleus {ECO:0000269|PubMed:17322883}. Cell projection, axon {ECO:0000269|PubMed:24794856}. Cell projection, dendrite {ECO:0000269|PubMed:24794856}. Note=Mainly cytoplasmic. {ECO:0000269|PubMed:17322883}.
Q96JJ3	reviewed	ELMO2_HUMAN	Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A)	ELMO2 CED12A KIAA1834	Homo sapiens (Human)	720	FUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:11703939, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:27476657}.		actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell chemotaxis [GO:0060326]; cell motility [GO:0048870]; phagocytosis [GO:0006909]	cytosol [GO:0005829]; membrane [GO:0016020]	receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]	cytosol [GO:0005829]; membrane [GO:0016020]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell chemotaxis [GO:0060326]; cell motility [GO:0048870]; phagocytosis [GO:0006909]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20679435}. Cytoplasm, cytosol {ECO:0000269|PubMed:20679435}. Membrane {ECO:0000269|PubMed:20679435}.
Q96JJ6	reviewed	JPH4_HUMAN	Junctophilin-4 (JP-4) (Junctophilin-like 1 protein)	JPH4 JPHL1 KIAA1831	Homo sapiens (Human)	628	FUNCTION: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). {ECO:0000250}.		calcium ion transport into cytosol [GO:0060402]; learning [GO:0007612]; neuromuscular process controlling balance [GO:0050885]; regulation of cytokine production [GO:0001817]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of store-operated calcium entry [GO:2001256]; regulation of synaptic plasticity [GO:0048167]	dendritic shaft [GO:0043198]; endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]		dendritic shaft [GO:0043198]; endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; calcium ion transport into cytosol [GO:0060402]; learning [GO:0007612]; neuromuscular process controlling balance [GO:0050885]; regulation of cytokine production [GO:0001817]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of store-operated calcium entry [GO:2001256]; regulation of synaptic plasticity [GO:0048167]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). {ECO:0000250}.
Q96JJ7	reviewed	TMX3_HUMAN	Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3)	TMX3 KIAA1830 TXNDC10	Homo sapiens (Human)	454	FUNCTION: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. {ECO:0000269|PubMed:15623505}.		peptidyl-cysteine oxidation [GO:0018171]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; peptidyl-cysteine oxidation [GO:0018171]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15623505}; Single-pass membrane protein {ECO:0000269|PubMed:15623505}.
Q96JK2	reviewed	DCAF5_HUMAN	DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22)	DCAF5 BCRG2 KIAA1824 WDR22	Homo sapiens (Human)	942	FUNCTION: Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}.		negative regulation of fatty acid biosynthetic process [GO:0045717]; protein ubiquitination [GO:0016567]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; negative regulation of fatty acid biosynthetic process [GO:0045717]; protein ubiquitination [GO:0016567]	
Q96JK9	reviewed	MAML3_HUMAN	Mastermind-like protein 3 (Mam-3)	MAML3 KIAA1816	Homo sapiens (Human)	1138	FUNCTION: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158}.		Notch signaling pathway [GO:0007219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; Notch signaling pathway [GO:0007219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:12370315}. Note=Nuclear, in a punctate manner.
Q96JL9	reviewed	ZN333_HUMAN	Zinc finger protein 333	ZNF333 KIAA1806	Homo sapiens (Human)	665	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96JM2	reviewed	ZN462_HUMAN	Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP)	ZNF462 KIAA1803	Homo sapiens (Human)	2506	FUNCTION: Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}.		chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}.
Q96JM3	reviewed	CHAP1_HUMAN	Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828)	CHAMP1 C13orf8 CAMP CHAMP KIAA1802 ZNF828	Homo sapiens (Human)	812	FUNCTION: Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.		attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; protein localization to kinetochore [GO:0034501]; protein localization to microtubule [GO:0035372]; sister chromatid biorientation [GO:0031134]	condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	metal ion binding [GO:0046872]	condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; metal ion binding [GO:0046872]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; protein localization to kinetochore [GO:0034501]; protein localization to microtubule [GO:0035372]; sister chromatid biorientation [GO:0031134]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21063390}. Chromosome {ECO:0000269|PubMed:21063390}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:21063390}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:21063390}.
Q96JM7	reviewed	LMBL3_HUMAN	Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1)	L3MBTL3 KIAA1798 MBT1	Homo sapiens (Human)	780	FUNCTION: Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:30442713, PubMed:29691401). Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250|UniProtKB:Q8BLB7, ECO:0000269|PubMed:29030483, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}.		chromatin organization [GO:0006325]; erythrocyte maturation [GO:0043249]; granulocyte differentiation [GO:0030851]; macrophage differentiation [GO:0030225]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; regulation of DNA methylation-dependent heterochromatin formation [GO:0090308]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; methylation-dependent protein binding [GO:0140034]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; methylation-dependent protein binding [GO:0140034]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; erythrocyte maturation [GO:0043249]; granulocyte differentiation [GO:0030851]; macrophage differentiation [GO:0030225]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; regulation of DNA methylation-dependent heterochromatin formation [GO:0090308]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33980486}.
Q96JN0	reviewed	LCOR_HUMAN	Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2)	LCOR C10orf12 KIAA1795 MLR2	Homo sapiens (Human)	433	FUNCTION: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. {ECO:0000250, ECO:0000269|PubMed:12535528}.		cellular response to estradiol stimulus [GO:0071392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; histone methyltransferase binding [GO:1990226]; nuclear estrogen receptor binding [GO:0030331]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; ubiquitin-specific protease binding [GO:1990381]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; histone methyltransferase binding [GO:1990226]; nuclear estrogen receptor binding [GO:0030331]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; ubiquitin-specific protease binding [GO:1990381]; cellular response to estradiol stimulus [GO:0071392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000269|PubMed:12535528}.
Q96JN2	reviewed	CC136_HUMAN	Coiled-coil domain-containing protein 136 (Nasopharyngeal carcinoma-associated gene 6 protein)	CCDC136 KIAA1793 NAG6	Homo sapiens (Human)	1154	FUNCTION: May play a role in acrosome formation in spermatogenesis and in fertilization. {ECO:0000250|UniProtKB:Q3TVA9}.	MISCELLANEOUS: Restriction fragment length polymorphisms (RFLPs) in gastric cancer showed loss of 5 kb fragment in comparison with the corresponding normal tissue.	acrosome assembly [GO:0001675]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]	acrosomal membrane [GO:0002080]		acrosomal membrane [GO:0002080]; acrosome assembly [GO:0001675]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q3TVA9}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q3TVA9}. Note=Exclusively localized on a peripheral part of acrosome membrane (Golgi phase), localized on the equatorial segment of the acrosome (maturation phase). {ECO:0000250|UniProtKB:Q3TVA9}.
Q96JP0	reviewed	FEM1C_HUMAN	Protein fem-1 homolog C (FEM1c) (FEM1-gamma)	FEM1C KIAA1785	Homo sapiens (Human)	617	FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578, PubMed:33398170, PubMed:33398168). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:29775578, PubMed:33398170, PubMed:33398168). The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (PubMed:33398170, PubMed:33398168). The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). Promotes ubiquitination and degradation of SLBP (PubMed:28118078). {ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:28118078, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:33398168, ECO:0000269|PubMed:33398170}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ubiquitin ligase complex [GO:0000151]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ubiquitin ligase complex [GO:0000151]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	
Q96JP5	reviewed	ZFP91_HUMAN	E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91)	ZFP91 ZNF757 FKSG11	Homo sapiens (Human)	570	FUNCTION: Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}.	MISCELLANEOUS: In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity.	activation of NF-kappaB-inducing kinase activity [GO:0007250]; protein K63-linked ubiquitination [GO:0070534]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; protein K63-linked ubiquitination [GO:0070534]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12738986}.
Q96JP9	reviewed	CDHR1_HUMAN	Cadherin-related family member 1 (Photoreceptor cadherin) (prCAD) (Protocadherin-21)	CDHR1 KIAA1775 PCDH21 PRCAD	Homo sapiens (Human)	859	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell morphogenesis [GO:0008594]; photoreceptor cell outer segment organization [GO:0035845]	photoreceptor outer segment membrane [GO:0042622]	calcium ion binding [GO:0005509]	photoreceptor outer segment membrane [GO:0042622]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell morphogenesis [GO:0008594]; photoreceptor cell outer segment organization [GO:0035845]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Localized at the junction between the inner and outer segments of rod and cone photoreceptors cells. Confined to the base of the OS. Localized on the edges of nascent evaginating disks on the side of the OS opposite the connecting cilium. Expressed at postnatal day 2 at the apical tip of the rod photoreceptor cells, the site of the developing OS. Colocalized with rhodopsin between postnatal days 2 and 9 at the base of the growing OS region (By similarity). {ECO:0000250}.
Q96JQ0	reviewed	PCD16_HUMAN	Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1)	DCHS1 CDH19 CDH25 FIB1 KIAA1773 PCDH16	Homo sapiens (Human)	3298	FUNCTION: Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). {ECO:0000269|PubMed:26258302}.		branching involved in ureteric bud morphogenesis [GO:0001658]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration involved in endocardial cushion formation [GO:0003273]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cochlea development [GO:0090102]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; mitral valve formation [GO:0003192]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; pattern specification process [GO:0007389]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]	apical part of cell [GO:0045177]; catenin complex [GO:0016342]; membrane [GO:0016020]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	apical part of cell [GO:0045177]; catenin complex [GO:0016342]; membrane [GO:0016020]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; branching involved in ureteric bud morphogenesis [GO:0001658]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration involved in endocardial cushion formation [GO:0003273]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cochlea development [GO:0090102]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; mitral valve formation [GO:0003192]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; pattern specification process [GO:0007389]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=In the embryonic cortex, FAT4 and DCHS1 accumulated at the cell-cell boundaries located apical to the adherens junction. {ECO:0000250}.
Q96JQ5	reviewed	M4A4A_HUMAN	Membrane-spanning 4-domains subfamily A member 4A (CD20 antigen-like 1) (Four-span transmembrane protein 1)	MS4A4A 4SPAN1 CD20L1 MS4A4 HDCME31P	Homo sapiens (Human)	239	FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex.			endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]		endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q96JS3	reviewed	PGBD1_HUMAN	PiggyBac transposable element-derived protein 1 (Cerebral protein 4)	PGBD1 hucep-4	Homo sapiens (Human)	809			regulation of transcription by RNA polymerase II [GO:0006357]	membrane [GO:0016020]	DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]	membrane [GO:0016020]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q96JW4	reviewed	S41A2_HUMAN	Solute carrier family 41 member 2	SLC41A2	Homo sapiens (Human)	573	FUNCTION: Acts as a plasma-membrane magnesium transporter (PubMed:16984228). Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+) (By similarity). {ECO:0000250|UniProtKB:Q8BYR8, ECO:0000269|PubMed:16984228}.		cobalt ion transport [GO:0006824]; iron ion transport [GO:0006826]; magnesium ion transport [GO:0015693]; manganese ion transport [GO:0006828]; nickel cation transport [GO:0015675]	plasma membrane [GO:0005886]	magnesium ion transmembrane transporter activity [GO:0015095]	plasma membrane [GO:0005886]; magnesium ion transmembrane transporter activity [GO:0015095]; cobalt ion transport [GO:0006824]; iron ion transport [GO:0006826]; magnesium ion transport [GO:0015693]; manganese ion transport [GO:0006828]; nickel cation transport [GO:0015675]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16984228}; Multi-pass membrane protein {ECO:0000255}.
Q96JX3	reviewed	SRAC1_HUMAN	Protein SERAC1 (Serine active site-containing protein 1)	SERAC1	Homo sapiens (Human)	654	FUNCTION: Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway. {ECO:0000269|PubMed:22683713}.		extracellular matrix organization [GO:0030198]; intracellular cholesterol transport [GO:0032367]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid biosynthetic process [GO:0008654]	endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]		endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]; extracellular matrix organization [GO:0030198]; intracellular cholesterol transport [GO:0032367]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid biosynthetic process [GO:0008654]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:22683713}. Mitochondrion {ECO:0000269|PubMed:22683713}. Note=Localizes at the endoplasmic reticulum and at the endoplasmic reticulum-mitochondria interface.
Q96JY0	reviewed	MAEL_HUMAN	Protein maelstrom homolog	MAEL	Homo sapiens (Human)	434	FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity). {ECO:0000250|UniProtKB:Q8BVN9}.		cell morphogenesis [GO:0000902]; ectopic germ cell programmed cell death [GO:0035234]; fertilization [GO:0009566]; genomic imprinting [GO:0071514]; homologous chromosome pairing at meiosis [GO:0007129]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; male meiotic nuclear division [GO:0007140]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of reproductive process [GO:2000242]; negative regulation of transcription by RNA polymerase II [GO:0000122]; piRNA processing [GO:0034587]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of organ growth [GO:0046620]; regulatory ncRNA-mediated gene silencing [GO:0031047]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	autosome [GO:0030849]; chromatin [GO:0000785]; chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634]; P granule [GO:0043186]; perinuclear region of cytoplasm [GO:0048471]; piP-body [GO:0071547]; XY body [GO:0001741]	sequence-specific DNA binding [GO:0043565]	autosome [GO:0030849]; chromatin [GO:0000785]; chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634]; P granule [GO:0043186]; perinuclear region of cytoplasm [GO:0048471]; piP-body [GO:0071547]; XY body [GO:0001741]; sequence-specific DNA binding [GO:0043565]; cell morphogenesis [GO:0000902]; ectopic germ cell programmed cell death [GO:0035234]; fertilization [GO:0009566]; genomic imprinting [GO:0071514]; homologous chromosome pairing at meiosis [GO:0007129]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; male meiotic nuclear division [GO:0007140]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of reproductive process [GO:2000242]; negative regulation of transcription by RNA polymerase II [GO:0000122]; piRNA processing [GO:0034587]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of organ growth [GO:0046620]; regulatory ncRNA-mediated gene silencing [GO:0031047]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BVN9}. Nucleus {ECO:0000250|UniProtKB:Q8BVN9}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity). {ECO:0000250|UniProtKB:Q8BVN9}.
Q96JY6	reviewed	PDLI2_HUMAN	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique)	PDLIM2 PP6345	Homo sapiens (Human)	352	FUNCTION: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}.		actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]; protein catabolic process [GO:0030163]	adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; filamentous actin [GO:0031941]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; filamin binding [GO:0031005]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; myosin heavy chain binding [GO:0032036]; ubiquitin protein ligase binding [GO:0031625]	adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; filamentous actin [GO:0031941]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; filamin binding [GO:0031005]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; myosin heavy chain binding [GO:0032036]; ubiquitin protein ligase binding [GO:0031625]; actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]; protein catabolic process [GO:0030163]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15659642}. Nucleus {ECO:0000269|PubMed:15659642}. Note=May be partially nuclear.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus.
Q96JZ2	reviewed	HSH2D_HUMAN	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)	HSH2D ALX	Homo sapiens (Human)	352	FUNCTION: May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}.		negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of mitochondrial depolarization [GO:0051902]; signal transduction [GO:0007165]; T cell activation [GO:0042110]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	protein-macromolecule adaptor activity [GO:0030674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-macromolecule adaptor activity [GO:0030674]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of mitochondrial depolarization [GO:0051902]; signal transduction [GO:0007165]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q96K12	reviewed	FACR2_HUMAN	Fatty acyl-CoA reductase 2 (EC 1.2.1.84) (Male sterility domain-containing protein 1)	FAR2 MLSTD1	Homo sapiens (Human)	515	FUNCTION: Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates (PubMed:15220348). It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity). {ECO:0000250|UniProtKB:Q8WVX9, ECO:0000269|PubMed:15220348}.		long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025]	peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	alcohol-forming long-chain fatty acyl-CoA reductase activity [GO:0102965]; alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019]; oxidoreductase activity [GO:0016491]	peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; alcohol-forming long-chain fatty acyl-CoA reductase activity [GO:0102965]; alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019]; oxidoreductase activity [GO:0016491]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:15220348, ECO:0000269|PubMed:24108123}; Single-pass membrane protein {ECO:0000305|PubMed:24108123}.
Q96K19	reviewed	RN170_HUMAN	E3 ubiquitin-protein ligase RNF170 (EC 2.3.2.27) (Putative LAG1-interacting protein) (RING finger protein 170) (RING-type E3 ubiquitin transferase RNF170)	RNF170	Homo sapiens (Human)	258	FUNCTION: E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. {ECO:0000269|PubMed:21610068}.		protein ubiquitination [GO:0016567]	endoplasmic reticulum membrane [GO:0005789]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum membrane [GO:0005789]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21610068}; Multi-pass membrane protein {ECO:0000269|PubMed:21610068}.
Q96K21	reviewed	ANCHR_HUMAN	Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19)	ZFYVE19 ANCHR MPFYVE	Homo sapiens (Human)	471	FUNCTION: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. {ECO:0000269|PubMed:24814515}.		abscission [GO:0009838]; cell division [GO:0051301]; mitotic cytokinesis checkpoint signaling [GO:0044878]; negative regulation of cytokinesis [GO:0032466]	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; midbody [GO:0030496]	metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; midbody [GO:0030496]; metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]; abscission [GO:0009838]; cell division [GO:0051301]; mitotic cytokinesis checkpoint signaling [GO:0044878]; negative regulation of cytokinesis [GO:0032466]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24814515}. Cleavage furrow {ECO:0000269|PubMed:24814515}. Midbody, Midbody ring {ECO:0000269|PubMed:24814515}. Note=Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis. {ECO:0000269|PubMed:24814515}.
Q96K30	reviewed	RITA1_HUMAN	RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein)	RITA1 C12orf52 RITA PSEC0043	Homo sapiens (Human)	269	FUNCTION: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. {ECO:0000269|PubMed:21102556}.		negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; nuclear export [GO:0051168]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	tubulin binding [GO:0015631]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tubulin binding [GO:0015631]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; nuclear export [GO:0051168]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21102556}. Nucleus {ECO:0000269|PubMed:21102556}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21102556}. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear.
Q96K58	reviewed	ZN668_HUMAN	Zinc finger protein 668	ZNF668	Homo sapiens (Human)	619	FUNCTION: May be involved in transcriptional regulation. May play a role in DNA repair process. {ECO:0000269|PubMed:34313816}.		DNA repair [GO:0006281]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; DNA repair [GO:0006281]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34313816}.
Q96K76	reviewed	UBP47_HUMAN	Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47)	USP47	Homo sapiens (Human)	1375	FUNCTION: Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}.		base-excision repair [GO:0006284]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; response to xenobiotic stimulus [GO:0009410]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; WD40-repeat domain binding [GO:0071987]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; WD40-repeat domain binding [GO:0071987]; base-excision repair [GO:0006284]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21362556}.
Q96K78	reviewed	AGRG7_HUMAN	Adhesion G-protein coupled receptor G7 (G-protein coupled receptor 128)	ADGRG7 GPR128	Homo sapiens (Human)	797	FUNCTION: Orphan receptor.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q96K80	reviewed	ZC3HA_HUMAN	Zinc finger CCCH domain-containing protein 10	ZC3H10 ZC3HDC10	Homo sapiens (Human)	434	FUNCTION: Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA. {ECO:0000269|PubMed:28431233}.		negative regulation of miRNA processing [GO:1903799]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of RNA splicing [GO:0043484]	nucleus [GO:0005634]	metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; negative regulation of miRNA processing [GO:1903799]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28431233}.
Q96K83	reviewed	ZN521_HUMAN	Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3)	ZNF521 EHZF LIP3	Homo sapiens (Human)	1311	FUNCTION: Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. {ECO:0000269|PubMed:14630787}.		neuron fate commitment [GO:0048663]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; neuron fate commitment [GO:0048663]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96KA5	reviewed	CLP1L_HUMAN	Lipid scramblase CLPTM1L (Cisplatin resistance-related protein 9) (CRR9p) (Cleft lip and palate transmembrane protein 1-like protein) (CLPTM1-like protein)	CLPTM1L CRR9	Homo sapiens (Human)	538	FUNCTION: Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI) (PubMed:35344438). GPI is a lipid glycoconjugate involved in post-translational modification of proteins (PubMed:35344438). Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro (PubMed:35344438). {ECO:0000269|PubMed:35344438}.		apoptotic process [GO:0006915]	endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	phospholipid scramblase activity [GO:0017128]	endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; phospholipid scramblase activity [GO:0017128]; apoptotic process [GO:0006915]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:35344438}; Multi-pass membrane protein {ECO:0000255}.
Q96KB5	reviewed	TOPK_HUMAN	Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase)	PBK TOPK	Homo sapiens (Human)	322	FUNCTION: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}.		cellular response to UV [GO:0034644]; mitotic cell cycle [GO:0000278]; negative regulation of inflammatory response [GO:0050728]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stress-activated MAPK cascade [GO:0032873]; phosphorylation [GO:0016310]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; stress-activated MAPK cascade [GO:0051403]	nucleus [GO:0005634]	ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	nucleus [GO:0005634]; ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; cellular response to UV [GO:0034644]; mitotic cell cycle [GO:0000278]; negative regulation of inflammatory response [GO:0050728]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stress-activated MAPK cascade [GO:0032873]; phosphorylation [GO:0016310]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; stress-activated MAPK cascade [GO:0051403]	
Q96KC8	reviewed	DNJC1_HUMAN	DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1)	DNAJC1 HTJ1	Homo sapiens (Human)	554	FUNCTION: May modulate protein synthesis. {ECO:0000250}.		negative regulation of proteolysis [GO:0045861]; protein folding [GO:0006457]; regulation of protein secretion [GO:0050708]; regulation of translation [GO:0006417]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	ATPase activator activity [GO:0001671]; DNA binding [GO:0003677]; protein-folding chaperone binding [GO:0051087]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; ATPase activator activity [GO:0001671]; DNA binding [GO:0003677]; protein-folding chaperone binding [GO:0051087]; negative regulation of proteolysis [GO:0045861]; protein folding [GO:0006457]; regulation of protein secretion [GO:0050708]; regulation of translation [GO:0006417]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus membrane; Single-pass type I membrane protein. Microsome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q96KG7	reviewed	MEG10_HUMAN	Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10)	MEGF10 KIAA1780	Homo sapiens (Human)	1140	FUNCTION: Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117). Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:20828568, PubMed:17643423). Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117). Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977, Ref.16). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:17498693, PubMed:17643423, PubMed:20828568, PubMed:22101682, PubMed:27170117, PubMed:28498977). {ECO:0000269|PubMed:17205124, ECO:0000269|PubMed:17498693, ECO:0000269|PubMed:17643423, ECO:0000269|PubMed:20828568, ECO:0000269|PubMed:22101682, ECO:0000269|PubMed:27170117, ECO:0000269|PubMed:28498977, ECO:0000269|Ref.16}.		apoptotic cell clearance [GO:0043277]; apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; muscle cell proliferation [GO:0033002]; myoblast development [GO:0048627]; myoblast migration [GO:0051451]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of myoblast proliferation [GO:2000288]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841]	cell projection [GO:0042995]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]	complement component C1q complex binding [GO:0001849]; Notch binding [GO:0005112]; scavenger receptor activity [GO:0005044]	cell projection [GO:0042995]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; complement component C1q complex binding [GO:0001849]; Notch binding [GO:0005112]; scavenger receptor activity [GO:0005044]; apoptotic cell clearance [GO:0043277]; apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; muscle cell proliferation [GO:0033002]; myoblast development [GO:0048627]; myoblast migration [GO:0051451]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of myoblast proliferation [GO:2000288]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27170117}; Single-pass type I membrane protein. Cell projection, phagocytic cup {ECO:0000269|PubMed:17205124}. Note=Enriched at the sites of contact with apoptotic thymocyte cells (PubMed:17205124). Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup (PubMed:17498693). Colocalizes with ABCA1 in absence of any phagocytic challenge (PubMed:17205124). Does not localize within lamellipodia (PubMed:17498693). Does not localize with MEGF11 (PubMed:17498693). {ECO:0000269|PubMed:17205124, ECO:0000269|PubMed:17498693}.
Q96KG9	reviewed	SCYL1_HUMAN	N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase)	SCYL1 CVAK90 GKLP NTKL TAPK TEIF TRAP HT019	Homo sapiens (Human)	808	FUNCTION: Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). Has no detectable kinase activity in vitro (PubMed:18556652). {ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}.; FUNCTION: Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. {ECO:0000269|PubMed:18556652}.	MISCELLANEOUS: [Isoform 3]: Non-canonical splice junctions. {ECO:0000305}.	inflammatory response [GO:0006954]; neuron development [GO:0048666]; protein localization [GO:0008104]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; spinal cord motor neuron differentiation [GO:0021522]	cis-Golgi network [GO:0005801]; COPI vesicle coat [GO:0030126]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA binding [GO:0003677]; protein tyrosine kinase activity [GO:0004713]	cis-Golgi network [GO:0005801]; COPI vesicle coat [GO:0030126]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA binding [GO:0003677]; protein tyrosine kinase activity [GO:0004713]; inflammatory response [GO:0006954]; neuron development [GO:0048666]; protein localization [GO:0008104]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; spinal cord motor neuron differentiation [GO:0021522]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18556652}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:18556652}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:18556652}. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.; SUBCELLULAR LOCATION: [Isoform 6]: Nucleus {ECO:0000269|PubMed:15504359}.
Q96KK3	reviewed	KCNS1_HUMAN	Potassium voltage-gated channel subfamily S member 1 (Delayed-rectifier K(+) channel alpha subunit 1) (Voltage-gated potassium channel subunit Kv9.1)	KCNS1	Homo sapiens (Human)	526	FUNCTION: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:10484328). {ECO:0000269|PubMed:10484328}.		potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of delayed rectifier potassium channel activity [GO:1902259]	perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; potassium channel regulator activity [GO:0015459]	perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; potassium channel regulator activity [GO:0015459]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of delayed rectifier potassium channel activity [GO:1902259]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10484328}; Multi-pass membrane protein {ECO:0000305}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 (PubMed:10484328). {ECO:0000269|PubMed:10484328}.
Q96KK4	reviewed	O10C1_HUMAN	Olfactory receptor 10C1 (Hs6M1-17) (Olfactory receptor 10C2)	OR10C1 OR10C2	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96KK5	reviewed	H2A1H_HUMAN	Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s)	H2AC12 HIST1H2AH HIST1H2AI	Homo sapiens (Human)	128	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.			extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q96KM6	reviewed	Z512B_HUMAN	Zinc finger protein 512B	ZNF512B KIAA1196	Homo sapiens (Human)	892	FUNCTION: May be involved in transcriptional regulation.		negative regulation of miRNA transcription [GO:1902894]	nucleoplasm [GO:0005654]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleoplasm [GO:0005654]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of miRNA transcription [GO:1902894]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96KN2	reviewed	CNDP1_HUMAN	Beta-Ala-His dipeptidase (EC 3.4.13.20) (CNDP dipeptidase 1) (Carnosine dipeptidase 1) (Glutamate carboxypeptidase-like protein 2) (Serum carnosinase)	CNDP1 CN1 CPGL2 UNQ1915/PRO4380	Homo sapiens (Human)	507	FUNCTION: Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-3-methyl-histidine). {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:24891507}.		proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246]	cytosol [GO:0005829]; extracellular region [GO:0005576]	carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]	cytosol [GO:0005829]; extracellular region [GO:0005576]; carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]; proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12473676}.
Q96KN3	reviewed	PKNX2_HUMAN	Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)	PKNOX2 PREP2	Homo sapiens (Human)	472			regulation of transcription by RNA polymerase II [GO:0006357]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]	actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11549286}.
Q96KN4	reviewed	LRAT1_HUMAN	Protein LRATD1 (LRAT domain-containing 1) (Neurologic sensory protein 1) (NSE1) (Protein FAM84A)	LRATD1 FAM84A NSE1	Homo sapiens (Human)	292	FUNCTION: May play a role in cell morphology and motility. {ECO:0000269|PubMed:16820875}.		cell morphogenesis [GO:0000902]; cell motility [GO:0048870]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; cell morphogenesis [GO:0000902]; cell motility [GO:0048870]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16820875}.
Q96KN7	reviewed	RPGR1_HUMAN	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1)	RPGRIP1	Homo sapiens (Human)	1286	FUNCTION: May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells. {ECO:0000250|UniProtKB:Q9EPQ2, ECO:0000305|PubMed:10958648}.		neural precursor cell proliferation [GO:0061351]; non-motile cilium assembly [GO:1905515]; response to stimulus [GO:0050896]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601]	axoneme [GO:0005930]; ciliary rootlet [GO:0035253]; photoreceptor connecting cilium [GO:0032391]; photoreceptor distal connecting cilium [GO:0120206]	thromboxane A2 receptor binding [GO:0031870]	axoneme [GO:0005930]; ciliary rootlet [GO:0035253]; photoreceptor connecting cilium [GO:0032391]; photoreceptor distal connecting cilium [GO:0120206]; thromboxane A2 receptor binding [GO:0031870]; neural precursor cell proliferation [GO:0061351]; non-motile cilium assembly [GO:1905515]; response to stimulus [GO:0050896]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:21685204}. Note=Situated between the axonemal microtubules and the plasma membrane (By similarity). In the retinal photoreceptor cell layer, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (By similarity). Colocalizes with RGPR in the photoreceptor connecting cilium (By similarity). {ECO:0000250|UniProtKB:Q9EPQ2}.
Q96KN8	reviewed	PLAT5_HUMAN	Phospholipase A and acyltransferase 5 (Ca(2+)-independent N-acyltransferase) (iNAT) (EC 2.3.1.-, EC 3.1.1.32, EC 3.1.1.4) (H-rev107-like protein 5) (HRAS-like suppressor 5) (HRSL5)	PLAAT5 HRASLS5 HRLP5	Homo sapiens (Human)	279	FUNCTION: Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:22825852). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19000777, PubMed:22825852). {ECO:0000269|PubMed:19000777, ECO:0000269|PubMed:22825852, ECO:0000303|PubMed:26503625}.		N-acylphosphatidylethanolamine metabolic process [GO:0070292]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; N-acyltransferase activity [GO:0016410]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; N-acyltransferase activity [GO:0016410]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q4KLN5}.
Q96KP1	reviewed	EXOC2_HUMAN	Exocyst complex component 2 (Exocyst complex component Sec5)	EXOC2 SEC5 SEC5L1	Homo sapiens (Human)	924	FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000269|PubMed:12459492, ECO:0000269|PubMed:32639540}.		exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of entry of bacterium into host cell [GO:2000535]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; membrane [GO:0016020]; plasma membrane [GO:0005886]	protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of entry of bacterium into host cell [GO:2000535]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	SUBCELLULAR LOCATION: Midbody, Midbody ring {ECO:0000269|PubMed:16213214, ECO:0000269|PubMed:18756269}. Note=Recruitment to the midbody does not require RALA, nor RALB (PubMed:18756269). Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). {ECO:0000269|PubMed:16213214, ECO:0000269|PubMed:18756269}.
Q96KP4	reviewed	CNDP2_HUMAN	Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) (Peptidase A) (Threonyl dipeptidase)	CNDP2 CN2 CPGL HEL-S-13 PEPA	Homo sapiens (Human)	475	FUNCTION: Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (By similarity). Mediates threonyl dipeptide catabolism in a tissue-specific way (By similarity). Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism (PubMed:19346245, PubMed:12473676). Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis (PubMed:25964343). Plays a role in the regulation of cell cycle arrest and apoptosis (PubMed:17121880, PubMed:24395568). {ECO:0000250|UniProtKB:Q9D1A2, ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:17121880, ECO:0000269|PubMed:19346245, ECO:0000269|PubMed:24395568, ECO:0000269|PubMed:25964343}.	MISCELLANEOUS: The reverse proteolysis is not negligible in vivo as long as the substrates are present in considerable concentrations, such as upon physical exercice. N-lac-Phe plasma levels are increased in patients with PKU with increased plasma Phe levels. N-lactoyl-amino acids are present in many tissues. {ECO:0000269|PubMed:25964343}.; MISCELLANEOUS: [Isoform 2]: Lacks a part of the catalytic domain. {ECO:0000305}.	proteolysis [GO:0006508]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	alanylglutamate dipeptidase activity [GO:0103046]; carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; alanylglutamate dipeptidase activity [GO:0103046]; carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:17121880}.
Q96KP6	reviewed	TNIP3_HUMAN	TNFAIP3-interacting protein 3 (A20-binding inhibitor of NF-kappa-B activation 3) (ABIN-3) (Listeria-induced gene protein)	TNIP3 ABIN3 LIND	Homo sapiens (Human)	325	FUNCTION: Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. {ECO:0000269|PubMed:17088249}.		cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 4 signaling pathway [GO:0034142]	cytosol [GO:0005829]	polyubiquitin modification-dependent protein binding [GO:0031593]	cytosol [GO:0005829]; polyubiquitin modification-dependent protein binding [GO:0031593]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 4 signaling pathway [GO:0034142]	
Q96KQ4	reviewed	ASPP1_HUMAN	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B)	PPP1R13B ASPP1 KIAA0771	Homo sapiens (Human)	1090	FUNCTION: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540}.	MISCELLANEOUS: In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.	intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of cell cycle [GO:0045786]; regulation of apoptotic process [GO:0042981]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	p53 binding [GO:0002039]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; p53 binding [GO:0002039]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of cell cycle [GO:0045786]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11684014}. Nucleus {ECO:0000269|PubMed:11684014}. Note=Predominantly cytoplasmic. Some fraction is nuclear.
Q96KQ7	reviewed	EHMT2_HUMAN	Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)	EHMT2 BAT8 C6orf30 G9A KMT1C NG36	Homo sapiens (Human)	1210	FUNCTION: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. Recruited to the promoters of target genes through interaction with transcriptional repressor MSX1, leading to the inhibition of myoblast differentiation via transcriptional repression of differentiation factors (By similarity). {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}.		behavioral response to cocaine [GO:0048148]; cellular response to cocaine [GO:0071314]; cellular response to starvation [GO:0009267]; cellular response to xenobiotic stimulus [GO:0071466]; DNA methylation [GO:0006306]; DNA methylation on cytosine within a CG sequence [GO:0010424]; fertilization [GO:0009566]; histone lysine methylation [GO:0034968]; long-term memory [GO:0007616]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; oocyte development [GO:0048599]; organ growth [GO:0035265]; peptidyl-lysine dimethylation [GO:0018027]; phenotypic switching [GO:0036166]; regulation of DNA methylation [GO:0044030]; regulation of DNA replication [GO:0006275]; regulation of histone methylation [GO:0031060]; response to ethanol [GO:0045471]; response to fungicide [GO:0060992]; spermatid development [GO:0007286]; synaptonemal complex assembly [GO:0007130]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	C2H2 zinc finger domain binding [GO:0070742]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9me2 methyltransferase activity [GO:0140947]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein-lysine N-methyltransferase activity [GO:0016279]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; C2H2 zinc finger domain binding [GO:0070742]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9me2 methyltransferase activity [GO:0140947]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein-lysine N-methyltransferase activity [GO:0016279]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]; behavioral response to cocaine [GO:0048148]; cellular response to cocaine [GO:0071314]; cellular response to starvation [GO:0009267]; cellular response to xenobiotic stimulus [GO:0071466]; DNA methylation [GO:0006306]; DNA methylation on cytosine within a CG sequence [GO:0010424]; fertilization [GO:0009566]; histone lysine methylation [GO:0034968]; long-term memory [GO:0007616]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; oocyte development [GO:0048599]; organ growth [GO:0035265]; peptidyl-lysine dimethylation [GO:0018027]; phenotypic switching [GO:0036166]; regulation of DNA methylation [GO:0044030]; regulation of DNA replication [GO:0006275]; regulation of histone methylation [GO:0031060]; response to ethanol [GO:0045471]; response to fungicide [GO:0060992]; spermatid development [GO:0007286]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11316813}. Chromosome {ECO:0000269|PubMed:11316813}. Note=Associates with euchromatic regions (PubMed:11316813). Does not associate with heterochromatin (PubMed:11316813). {ECO:0000269|PubMed:11316813}.
Q96KR4	reviewed	LMLN_HUMAN	Leishmanolysin-like peptidase (EC 3.4.24.-) (Invadolysin)	LMLN	Homo sapiens (Human)	655	FUNCTION: Metalloprotease. {ECO:0000250|UniProtKB:Q9VH19}.		cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lipid droplet [GO:0005811]; membrane [GO:0016020]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lipid droplet [GO:0005811]; membrane [GO:0016020]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15557119}. Lipid droplet {ECO:0000269|PubMed:19706689}. Note=Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells. {ECO:0000269|PubMed:19706689}.
Q96KR6	reviewed	F210B_HUMAN	Protein FAM210B, mitochondrial	FAM210B C20orf108 PSEC0265	Homo sapiens (Human)	192	FUNCTION: Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398). {ECO:0000269|PubMed:26968549, ECO:0000269|PubMed:28594398}.		cellular response to estradiol stimulus [GO:0071392]; erythrocyte maturation [GO:0043249]; positive regulation of erythrocyte differentiation [GO:0045648]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; cellular response to estradiol stimulus [GO:0071392]; erythrocyte maturation [GO:0043249]; positive regulation of erythrocyte differentiation [GO:0045648]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:26968549}. Mitochondrion outer membrane {ECO:0000269|PubMed:28594398}; Multi-pass membrane protein {ECO:0000305}.
Q96KR7	reviewed	PHAR3_HUMAN	Phosphatase and actin regulator 3 (Scaffold-associated PP1-inhibiting protein) (Scapinin)	PHACTR3 C20orf101 SCAPIN1	Homo sapiens (Human)	559			actin cytoskeleton organization [GO:0030036]	nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]	actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864]	nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864]; actin cytoskeleton organization [GO:0030036]	SUBCELLULAR LOCATION: Nucleus matrix. Note=Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.
Q96KS0	reviewed	EGLN2_HUMAN	Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1)	EGLN2 EIT6	Homo sapiens (Human)	407	FUNCTION: Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}.		cell redox homeostasis [GO:0045454]; cellular response to hypoxia [GO:0071456]; intracellular estrogen receptor signaling pathway [GO:0030520]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; positive regulation of protein catabolic process [GO:0045732]; regulation of cell growth [GO:0001558]; regulation of neuron apoptotic process [GO:0043523]; response to hypoxia [GO:0001666]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; oxygen sensor activity [GO:0019826]; peptidyl-proline 4-dioxygenase activity [GO:0031545]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; oxygen sensor activity [GO:0019826]; peptidyl-proline 4-dioxygenase activity [GO:0031545]; cell redox homeostasis [GO:0045454]; cellular response to hypoxia [GO:0071456]; intracellular estrogen receptor signaling pathway [GO:0030520]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; positive regulation of protein catabolic process [GO:0045732]; regulation of cell growth [GO:0001558]; regulation of neuron apoptotic process [GO:0043523]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:12615973, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}.
Q96KV7	reviewed	WDR90_HUMAN	WD repeat-containing protein 90	WDR90 C16orf15 C16orf16 C16orf17 C16orf18 C16orf19 KIAA1924	Homo sapiens (Human)	1748	FUNCTION: Required for efficient primary cilium formation. {ECO:0000269|PubMed:28781053}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cilium assembly [GO:0060271]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]		centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28781053}.
Q96L08	reviewed	SUSD3_HUMAN	Sushi domain-containing protein 3	SUSD3 UNQ9387/PRO34275	Homo sapiens (Human)	255	FUNCTION: May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration. {ECO:0000269|PubMed:24413080}.			plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24413080}; Single-pass membrane protein {ECO:0000305}. Note=Prominently localized to cell-cell borders. {ECO:0000269|PubMed:24413080}.
Q96L12	reviewed	CALR3_HUMAN	Calreticulin-3 (Calreticulin-2) (Calsperin)	CALR3 CRT2	Homo sapiens (Human)	384	FUNCTION: During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. {ECO:0000250, ECO:0000269|PubMed:21590275}.		cell differentiation [GO:0030154]; protein folding [GO:0006457]; spermatogenesis [GO:0007283]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]; cell differentiation [GO:0030154]; protein folding [GO:0006457]; spermatogenesis [GO:0007283]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:21590275}.
Q96L21	reviewed	RL10L_HUMAN	Ribosomal protein uL16-like (60S ribosomal protein L10-like) (Large ribosomal subunit protein uL16-like)	RPL10L	Homo sapiens (Human)	214	FUNCTION: Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (By similarity). Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis (PubMed:12490704). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:32669547). The male germ cell-specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome (By similarity). It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm (By similarity). {ECO:0000250|UniProtKB:P86048, ECO:0000269|PubMed:12490704, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:32669547}.	MISCELLANEOUS: This gene has no introns in its coding regions, and therefore was most likely produced by retrotransposition of the original X-linked gene during evolution. {ECO:0000269|PubMed:12490704}.	cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; ribosomal large subunit assembly [GO:0000027]; spermatogenesis [GO:0007283]; translation [GO:0006412]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634]; polysome [GO:0005844]; ribosome [GO:0005840]	structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634]; polysome [GO:0005844]; ribosome [GO:0005840]; structural constituent of ribosome [GO:0003735]; cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; ribosomal large subunit assembly [GO:0000027]; spermatogenesis [GO:0007283]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680, ECO:0000305|PubMed:32669547}.
Q96L34	reviewed	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)	MARK4 KIAA1860 MARKL1	Homo sapiens (Human)	752	FUNCTION: Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cilium organization [GO:0044782]; intracellular signal transduction [GO:0035556]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; nervous system development [GO:0007399]; positive regulation of cell cycle [GO:0045787]; positive regulation of cilium assembly [GO:0045724]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein localization to centrosome [GO:1904781]; protein phosphorylation [GO:0006468]; regulation of centrosome cycle [GO:0046605]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; gamma-tubulin complex [GO:0000930]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; neuron projection [GO:0043005]	ATP binding [GO:0005524]; cytoskeletal anchor activity [GO:0008093]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; ubiquitin binding [GO:0043130]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; gamma-tubulin complex [GO:0000930]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; neuron projection [GO:0043005]; ATP binding [GO:0005524]; cytoskeletal anchor activity [GO:0008093]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; ubiquitin binding [GO:0043130]; cell cycle [GO:0007049]; cell division [GO:0051301]; cilium organization [GO:0044782]; intracellular signal transduction [GO:0035556]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; nervous system development [GO:0007399]; positive regulation of cell cycle [GO:0045787]; positive regulation of cilium assembly [GO:0045724]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein localization to centrosome [GO:1904781]; protein phosphorylation [GO:0006468]; regulation of centrosome cycle [GO:0046605]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14594945}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:28656979}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23400999}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23400999}. Cytoplasm {ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762}. Cell projection, dendrite {ECO:0000269|PubMed:23666762}. Note=Localized at the tips of neurite-like processes in differentiated neuroblast cells. Detected in the cytoplasm and neuropil of the hippocampus. {ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:23666762}.
Q96L42	reviewed	KCNH8_HUMAN	Potassium voltage-gated channel subfamily H member 8 (ELK1) (hElk1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Voltage-gated potassium channel subunit Kv12.1)	KCNH8	Homo sapiens (Human)	1107	FUNCTION: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.		potassium ion transmembrane transport [GO:0071805]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]	plasma membrane [GO:0005886]	voltage-gated potassium channel activity [GO:0005249]	plasma membrane [GO:0005886]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q96L46	reviewed	CPNS2_HUMAN	Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2)	CAPNS2	Homo sapiens (Human)	248	FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.			calpain complex [GO:0110158]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	calpain complex [GO:0110158]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}.
Q96L50	reviewed	LLR1_HUMAN	Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5)	LRR1 PPIL5	Homo sapiens (Human)	414	FUNCTION: Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1 (PubMed:11804328). {ECO:0000250|UniProtKB:D3YY91, ECO:0000269|PubMed:11804328, ECO:0000269|PubMed:15601820}.		protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]	cytosol [GO:0005829]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleus [GO:0005634]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34700328}.
Q96L58	reviewed	B3GT6_HUMAN	Beta-1,3-galactosyltransferase 6 (Beta-1,3-GalTase 6) (Beta3Gal-T6) (Beta3GalT6) (EC 2.4.1.134) (GAG GalTII) (Galactosyltransferase II) (Galactosylxylosylprotein 3-beta-galactosyltransferase) (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6)	B3GALT6	Homo sapiens (Human)	329	FUNCTION: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues. {ECO:0000269|PubMed:11551958, ECO:0000269|PubMed:23664117, ECO:0000269|PubMed:29443383}.		chondroitin sulfate biosynthetic process [GO:0030206]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; protein O-linked glycosylation [GO:0006493]; proteoglycan biosynthetic process [GO:0030166]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	galactosylxylosylprotein 3-beta-galactosyltransferase activity [GO:0047220]; UDP-galactosyltransferase activity [GO:0035250]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; galactosylxylosylprotein 3-beta-galactosyltransferase activity [GO:0047220]; UDP-galactosyltransferase activity [GO:0035250]; chondroitin sulfate biosynthetic process [GO:0030206]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; protein O-linked glycosylation [GO:0006493]; proteoglycan biosynthetic process [GO:0030166]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:11551958, ECO:0000269|PubMed:29443383}; Single-pass type II membrane protein {ECO:0000269|PubMed:11551958}.
Q96L73	reviewed	NSD1_HUMAN	Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)	NSD1 ARA267 KMT3B	Homo sapiens (Human)	2696	FUNCTION: Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}.		methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903025]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H4K20 methyltransferase activity [GO:0042799]; nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H4K20 methyltransferase activity [GO:0042799]; nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903025]	SUBCELLULAR LOCATION: Nucleus. Chromosome {ECO:0000305}.
Q96L91	reviewed	EP400_HUMAN	E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)	EP400 CAGH32 KIAA1498 KIAA1818 TNRC12	Homo sapiens (Human)	3159	FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.		DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]	NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; Swr1 complex [GO:0000812]	ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; protein antigen binding [GO:1990405]	NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; Swr1 complex [GO:0000812]; ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; protein antigen binding [GO:1990405]; DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549}.
Q96L92	reviewed	SNX27_HUMAN	Sorting nexin-27	SNX27 KIAA0488 My014	Homo sapiens (Human)	541	FUNCTION: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. {ECO:0000269|PubMed:17351151, ECO:0000269|PubMed:20733053, ECO:0000269|PubMed:21300787, ECO:0000269|PubMed:21303929, ECO:0000269|PubMed:21602791, ECO:0000269|PubMed:21926430, ECO:0000269|PubMed:22411990, ECO:0000269|PubMed:23563491}.	MISCELLANEOUS: [Isoform 3]: May be due to intron retention. {ECO:0000305}.	endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; establishment of natural killer cell polarity [GO:0001770]; intracellular protein transport [GO:0006886]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; signal transduction [GO:0007165]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; intracellular membrane-bounded organelle [GO:0043231]; Schaffer collateral - CA1 synapse [GO:0098685]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; intracellular membrane-bounded organelle [GO:0043231]; Schaffer collateral - CA1 synapse [GO:0098685]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; establishment of natural killer cell polarity [GO:0001770]; intracellular protein transport [GO:0006886]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:25851603}; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.
Q96L93	reviewed	KI16B_HUMAN	Kinesin-like protein KIF16B (Sorting nexin-23)	KIF16B C20orf23 KIAA1590 SNX23	Homo sapiens (Human)	1317	FUNCTION: Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}.		early endosome to late endosome transport [GO:0045022]; endoderm development [GO:0007492]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; formation of primary germ layer [GO:0001704]; Golgi to endosome transport [GO:0006895]; microtubule-based movement [GO:0007018]; receptor catabolic process [GO:0032801]; regulation of receptor recycling [GO:0001919]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; spindle [GO:0005819]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; plus-end-directed microtubule motor activity [GO:0008574]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; spindle [GO:0005819]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; plus-end-directed microtubule motor activity [GO:0008574]; early endosome to late endosome transport [GO:0045022]; endoderm development [GO:0007492]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; formation of primary germ layer [GO:0001704]; Golgi to endosome transport [GO:0006895]; microtubule-based movement [GO:0007018]; receptor catabolic process [GO:0032801]; regulation of receptor recycling [GO:0001919]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:15882625}. Cytoplasm {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14. {ECO:0000269|PubMed:15882625}.
Q96L96	reviewed	ALPK3_HUMAN	Alpha-protein kinase 3 (EC 2.7.11.1) (Muscle alpha-protein kinase)	ALPK3 KIAA1330 MAK	Homo sapiens (Human)	1907	FUNCTION: Involved in cardiomyocyte differentiation. {ECO:0000305|PubMed:26846950, ECO:0000305|PubMed:27106955, ECO:0000305|PubMed:28630369, ECO:0000305|PubMed:30046096}.		cardiac muscle cell development [GO:0055013]; heart development [GO:0007507]; phosphorylation [GO:0016310]	nucleus [GO:0005634]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cardiac muscle cell development [GO:0055013]; heart development [GO:0007507]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q924C5}.
Q96LA5	reviewed	FCRL2_HUMAN	Fc receptor-like protein 2 (FcR-like protein 2) (FcRL2) (Fc receptor homolog 2) (FcRH2) (IFGP family protein 4) (Immunoglobulin receptor translocation-associated protein 4) (SH2 domain-containing phosphatase anchor protein 1) (CD antigen CD307b)	FCRL2 FCRH2 IFGP4 IRTA4 SPAP1 UNQ9236/PRO31998	Homo sapiens (Human)	508	FUNCTION: May have an regulatory role in normal and neoplastic B cell development. {ECO:0000269|PubMed:11493702}.		cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]	cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]	protein phosphatase binding [GO:0019903]; signaling adaptor activity [GO:0035591]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein phosphatase binding [GO:0019903]; signaling adaptor activity [GO:0035591]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}.
Q96LA6	reviewed	FCRL1_HUMAN	Fc receptor-like protein 1 (FcR-like protein 1) (FcRL1) (Fc receptor homolog 1) (FcRH1) (IFGP family protein 1) (hIFGP1) (Immune receptor translocation-associated protein 5) (CD antigen CD307a)	FCRL1 FCRH1 IFGP1 IRTA5	Homo sapiens (Human)	429	FUNCTION: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. {ECO:0000269|PubMed:15479727}.		B cell activation [GO:0042113]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	coreceptor activity [GO:0015026]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; coreceptor activity [GO:0015026]; B cell activation [GO:0042113]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}.
Q96LA8	reviewed	ANM6_HUMAN	Protein arginine N-methyltransferase 6 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6) (Histone-arginine N-methyltransferase PRMT6)	PRMT6 HRMT1L6	Homo sapiens (Human)	375	FUNCTION: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869). Methylates HMGA1 (PubMed:16157300, PubMed:16159886). Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity). May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505). Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity). Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (PubMed:30420520). {ECO:0000250|UniProtKB:Q6NZB1, ECO:0000269|PubMed:11724789, ECO:0000269|PubMed:16157300, ECO:0000269|PubMed:16159886, ECO:0000269|PubMed:16600869, ECO:0000269|PubMed:17267505, ECO:0000269|PubMed:17898714, ECO:0000269|PubMed:18077460, ECO:0000269|PubMed:18079182, ECO:0000269|PubMed:19405910, ECO:0000269|PubMed:19509293, ECO:0000269|PubMed:20047962, ECO:0000269|PubMed:30420520}.		base-excision repair [GO:0006284]; cellular senescence [GO:0090398]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [GO:0019919]; protein modification process [GO:0036211]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of mitochondrion organization [GO:0010821]; regulation of signal transduction by p53 class mediator [GO:1901796]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone arginine N-methyltransferase activity [GO:0008469]; histone binding [GO:0042393]; histone H2AR3 methyltransferase activity [GO:0070612]; histone H3 methyltransferase activity [GO:0140938]; histone H3R2 methyltransferase activity [GO:0070611]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone arginine N-methyltransferase activity [GO:0008469]; histone binding [GO:0042393]; histone H2AR3 methyltransferase activity [GO:0070612]; histone H3 methyltransferase activity [GO:0140938]; histone H3R2 methyltransferase activity [GO:0070611]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; base-excision repair [GO:0006284]; cellular senescence [GO:0090398]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [GO:0019919]; protein modification process [GO:0036211]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of mitochondrion organization [GO:0010821]; regulation of signal transduction by p53 class mediator [GO:1901796]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11724789}.
Q96LB1	reviewed	MRGX2_HUMAN	Mas-related G-protein coupled receptor member X2	MRGPRX2 MRGX2	Homo sapiens (Human)	330	FUNCTION: Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A. {ECO:0000250|UniProtKB:Q3KNA1, ECO:0000269|PubMed:15823563, ECO:0000269|PubMed:21441599, ECO:0000269|PubMed:22069323, ECO:0000269|PubMed:23698749, ECO:0000269|PubMed:24930830, ECO:0000269|PubMed:25517090, ECO:0000305|PubMed:12915402}.		G protein-coupled receptor signaling pathway [GO:0007186]; mast cell activation [GO:0045576]; mast cell degranulation [GO:0043303]; positive regulation of cytokinesis [GO:0032467]; sensory perception of pain [GO:0019233]; sleep [GO:0030431]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; mast cell secretagogue receptor activity [GO:1990595]; neuropeptide binding [GO:0042923]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; mast cell secretagogue receptor activity [GO:1990595]; neuropeptide binding [GO:0042923]; G protein-coupled receptor signaling pathway [GO:0007186]; mast cell activation [GO:0045576]; mast cell degranulation [GO:0043303]; positive regulation of cytokinesis [GO:0032467]; sensory perception of pain [GO:0019233]; sleep [GO:0030431]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000255}.
Q96LB2	reviewed	MRGX1_HUMAN	Mas-related G-protein coupled receptor member X1 (Sensory neuron-specific G-protein coupled receptor 3/4)	MRGPRX1 MRGX1 SNSR3 SNSR4	Homo sapiens (Human)	322	FUNCTION: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner. {ECO:0000269|PubMed:11850634, ECO:0000269|PubMed:20004959, ECO:0000269|PubMed:26582731}.	MISCELLANEOUS: Activation of this receptor requires concentrations that exceed the chloroquine concentrations observed in plasma of patients undergoing chloroquine treatment. However, chloroquine accumulates at much higher level in the skin where the receptor is located. Chloroquine-induced itch is very common among black Africans (up to 70%) but less common in other populations.	acute-phase response [GO:0006953]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; response to chloroquine [GO:1902349]; signal transduction [GO:0007165]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888]; acute-phase response [GO:0006953]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; response to chloroquine [GO:1902349]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96LB3	reviewed	IFT74_HUMAN	Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2)	IFT74 CCDC2 CMG1	Homo sapiens (Human)	600	FUNCTION: Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium (PubMed:23990561). Binds beta-tubulin via its basic region (PubMed:23990561). Required for ciliogenesis (PubMed:23990561). Essential for flagellogenesis during spermatogenesis (PubMed:33689014). {ECO:0000269|PubMed:23990561, ECO:0000269|PubMed:33689014}.		cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intraciliary anterograde transport [GO:0035720]; intraciliary transport involved in cilium assembly [GO:0035735]; keratinocyte development [GO:0003334]; keratinocyte proliferation [GO:0043616]; negative regulation of keratinocyte proliferation [GO:0010839]; non-motile cilium assembly [GO:1905515]; Notch signaling pathway [GO:0007219]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of transcription by RNA polymerase II [GO:0045944]	acrosomal vesicle [GO:0001669]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; nucleus [GO:0005634]	beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]	acrosomal vesicle [GO:0001669]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; nucleus [GO:0005634]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intraciliary anterograde transport [GO:0035720]; intraciliary transport involved in cilium assembly [GO:0035735]; keratinocyte development [GO:0003334]; keratinocyte proliferation [GO:0043616]; negative regulation of keratinocyte proliferation [GO:0010839]; non-motile cilium assembly [GO:1905515]; Notch signaling pathway [GO:0007219]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:15024030}. Cytoplasmic vesicle {ECO:0000269|PubMed:11683410}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:33689014}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8BKE9}. Note=Localizes along primary cilia at interphase and around the basal body/centriole at interphase and mitosis (PubMed:15024030). In male germ cells, strongly expressed in the vesicles of spermatocytes and round spermatids and also in the acrosome and centrosome regions of elongating spermatids and in developing sperm tails (By similarity). {ECO:0000250|UniProtKB:Q8BKE9, ECO:0000269|PubMed:15024030}.
Q96LB8	reviewed	PGRP4_HUMAN	Peptidoglycan recognition protein 4 (Peptidoglycan recognition protein I-beta) (PGLYRPIbeta) (PGRP-I-beta) (Peptidoglycan recognition protein intermediate beta)	PGLYRP4 PGRPIB SBBI67	Homo sapiens (Human)	373	FUNCTION: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. {ECO:0000269|PubMed:16354652}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; peptidoglycan catabolic process [GO:0009253]	extracellular region [GO:0005576]; membrane [GO:0016020]; protein-containing complex [GO:0032991]	N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; protein heterodimerization activity [GO:0046982]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; protein heterodimerization activity [GO:0046982]; zinc ion binding [GO:0008270]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; peptidoglycan catabolic process [GO:0009253]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16354652}.
Q96LB9	reviewed	PGRP3_HUMAN	Peptidoglycan recognition protein 3 (Peptidoglycan recognition protein I-alpha) (PGLYRPIalpha) (PGRP-I-alpha) (Peptidoglycan recognition protein intermediate alpha)	PGLYRP3 PGRPIA	Homo sapiens (Human)	341	FUNCTION: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. {ECO:0000269|PubMed:16354652}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; biological process involved in interaction with host [GO:0051701]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; negative regulation of type II interferon production [GO:0032689]; peptidoglycan catabolic process [GO:0009253]	extracellular region [GO:0005576]; membrane [GO:0016020]; protein-containing complex [GO:0032991]	N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; protein heterodimerization activity [GO:0046982]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; protein heterodimerization activity [GO:0046982]; zinc ion binding [GO:0008270]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; biological process involved in interaction with host [GO:0051701]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; negative regulation of type II interferon production [GO:0032689]; peptidoglycan catabolic process [GO:0009253]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16354652}.
Q96LC7	reviewed	SIG10_HUMAN	Sialic acid-binding Ig-like lectin 10 (Siglec-10) (Siglec-like protein 2)	SIGLEC10 SLG2 UNQ477/PRO940	Homo sapiens (Human)	697	FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q80ZE3, ECO:0000269|PubMed:11284738, ECO:0000269|PubMed:25450598, ECO:0000305|PubMed:12163025}.		adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; innate immune response [GO:0045087]; negative regulation of inflammatory response to wounding [GO:0106015]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; phosphatase binding [GO:0019902]; SH2 domain binding [GO:0042169]; sialic acid binding [GO:0033691]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; phosphatase binding [GO:0019902]; SH2 domain binding [GO:0042169]; sialic acid binding [GO:0033691]; adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; innate immune response [GO:0045087]; negative regulation of inflammatory response to wounding [GO:0106015]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.
Q96LC9	reviewed	BMF_HUMAN	Bcl-2-modifying factor	BMF	Homo sapiens (Human)	184	FUNCTION: May play a role in apoptosis. Isoform 1 seems to be the main initiator.		anoikis [GO:0043276]; cellular response to UV [GO:0034644]; negative regulation of autophagy [GO:0010507]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]; anoikis [GO:0043276]; cellular response to UV [GO:0034644]; negative regulation of autophagy [GO:0010507]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]	
Q96LD4	reviewed	TRI47_HUMAN	E3 ubiquitin-protein ligase TRIM47 (EC 2.3.2.27) (Gene overexpressed in astrocytoma protein) (RING finger protein 100) (Tripartite motif-containing protein 47)	TRIM47 GOA RNF100	Homo sapiens (Human)	638	FUNCTION: E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD. {ECO:0000269|PubMed:29291351}.		protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; nucleus [GO:0005634]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11511098}. Nucleus {ECO:0000269|PubMed:11511098}.
Q96LD8	reviewed	SENP8_HUMAN	Sentrin-specific protease 8 (EC 3.4.22.-) (Deneddylase-1) (NEDD8-specific protease 1) (Protease, cysteine 2) (Sentrin/SUMO-specific protease SENP8)	SENP8 DEN1 NEDP1 PRSC2 FKSG8	Homo sapiens (Human)	212	FUNCTION: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. {ECO:0000269|PubMed:12730221, ECO:0000269|PubMed:12759362, ECO:0000269|PubMed:12759363, ECO:0000269|PubMed:15242646, ECO:0000269|PubMed:15775960}.		post-translational protein modification [GO:0043687]; proteolysis [GO:0006508]	cytosol [GO:0005829]	cysteine-type peptidase activity [GO:0008234]; deNEDDylase activity [GO:0019784]	cytosol [GO:0005829]; cysteine-type peptidase activity [GO:0008234]; deNEDDylase activity [GO:0019784]; post-translational protein modification [GO:0043687]; proteolysis [GO:0006508]	
Q96LI5	reviewed	CNO6L_HUMAN	CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4) (Carbon catabolite repressor protein 4 homolog B)	CNOT6L CCR4B	Homo sapiens (Human)	555	FUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:18377426, ECO:0000269|PubMed:21233283}.	MISCELLANEOUS: Depletion of CNOT6L causes cell growth defect.	mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; regulatory ncRNA-mediated gene silencing [GO:0031047]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; regulatory ncRNA-mediated gene silencing [GO:0031047]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:21233283}. Nucleus {ECO:0000269|PubMed:21233283}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:21233283}.
Q96LI6	reviewed	HSFY1_HUMAN	Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like)	HSFY1 HSF2L HSFY; HSFY2 HSF2L HSFY	Homo sapiens (Human)	401			regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15044259}. Cytoplasm {ECO:0000269|PubMed:15044259}.
Q96LJ7	reviewed	DHRS1_HUMAN	Dehydrogenase/reductase SDR family member 1 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 19C member 1) (Protein SDR19C1)	DHRS1 SDR19C1	Homo sapiens (Human)	313	FUNCTION: NADPH-dependent oxidoreductase which catalyzes the reduction of steroids (estrone, androstene-3,17-dione and cortisone) as well as prostaglandin E1, isatin and xenobiotics in vitro (PubMed:30031147). May have a role in steroid and/or xenobiotic metabolism (PubMed:30031147). {ECO:0000269|PubMed:30031147}.			endoplasmic reticulum [GO:0005783]	carbonyl reductase (NADPH) activity [GO:0004090]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]	endoplasmic reticulum [GO:0005783]; carbonyl reductase (NADPH) activity [GO:0004090]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:30031147}. Note=May be attached to the ER membrane by its C-terminus segment. {ECO:0000269|PubMed:30031147}.
Q96LJ8	reviewed	UBX10_HUMAN	UBX domain-containing protein 10 (UBX domain-containing protein 3)	UBXN10 UBXD3	Homo sapiens (Human)	280	FUNCTION: VCP/p97-binding protein required for ciliogenesis (PubMed:26389662). Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia (PubMed:26389662). UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 (PubMed:26389662). {ECO:0000269|PubMed:26389662}.		cilium assembly [GO:0060271]; ubiquitin-dependent ERAD pathway [GO:0030433]	cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]	ubiquitin binding [GO:0043130]	cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; ubiquitin binding [GO:0043130]; cilium assembly [GO:0060271]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:26389662}. Note=Recruited to cilia in a VCP-dependent manner. {ECO:0000269|PubMed:26389662}.
Q96LK0	reviewed	CEP19_HUMAN	Centrosomal protein of 19 kDa (Cep19)	CEP19 C3orf34 HSD5	Homo sapiens (Human)	163	FUNCTION: Required for ciliation (PubMed:28625565, PubMed:28428259, PubMed:28659385). Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28625565, PubMed:28428259). Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes (PubMed:28659385). {ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}.		cilium assembly [GO:0060271]; microtubule anchoring at centrosome [GO:0034454]; vesicle targeting, trans-Golgi to periciliary membrane compartment [GO:0097712]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]; cilium assembly [GO:0060271]; microtubule anchoring at centrosome [GO:0034454]; vesicle targeting, trans-Golgi to periciliary membrane compartment [GO:0097712]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:21399614}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24268657, ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. Note=Associates with the mother centriole in early interphase. Localizes to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase (PubMed:21399614). Localizes slightly apical to the subdistal appendage on the mother centriole, but below the distal appendage (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:28625565}.
Q96LL4	reviewed	CH048_HUMAN	Uncharacterized protein C8orf48	C8orf48	Homo sapiens (Human)	319							
Q96LL9	reviewed	DJC30_HUMAN	DnaJ homolog subfamily C member 30, mitochondrial (Williams-Beuren syndrome chromosomal region 18 protein)	DNAJC30 WBSCR18	Homo sapiens (Human)	226	FUNCTION: Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity). May be a chaperone protein involved in the turnover of the subunits of mitochondrial complex I N-module. It facilitates the degradation of N-module subunits damaged by oxidative stress, and contributes to complex I functional efficiency (PubMed:33465056). {ECO:0000250|UniProtKB:P59041, ECO:0000269|PubMed:33465056}.		ATP biosynthetic process [GO:0006754]; brain development [GO:0007420]; regulation of mitochondrial ATP synthesis coupled proton transport [GO:1905706]	mitochondrial inner membrane [GO:0005743]		mitochondrial inner membrane [GO:0005743]; ATP biosynthetic process [GO:0006754]; brain development [GO:0007420]; regulation of mitochondrial ATP synthesis coupled proton transport [GO:1905706]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30318146}; Single-pass membrane protein {ECO:0000255}.
Q96LM5	reviewed	SMIP2_HUMAN	Protein SPMIP2 (Sperm-associated microtubule inner protein 2)	SPMIP2 C4orf45	Homo sapiens (Human)	186							
Q96LM6	reviewed	SMIP9_HUMAN	Protein SPMIP9 (Sperm microtubule inner protein 9) (Testis-expressed sequence 37 protein) (Testis-specific conserved protein of 21 kDa)	SPMIP9 C2orf51 TEX37 TSC21	Homo sapiens (Human)	180				cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9DAG4}. Cytoplasm {ECO:0000269|PubMed:26168773}. Note=Present in the germ cell lineage at all stages (PubMed:26168773). {ECO:0000269|PubMed:26168773}.
Q96LR2	reviewed	LURA1_HUMAN	Leucine rich adaptor protein 1 (Leucine repeat adapter protein 35A)	LURAP1 C1orf190 LRAP35A LRP35A	Homo sapiens (Human)	239	FUNCTION: Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). {ECO:0000250|UniProtKB:D4A8G3, ECO:0000269|PubMed:21048106}.		positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21048106}.
Q96LR5	reviewed	UB2E2_HUMAN	Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)	UBE2E2 UBCH8	Homo sapiens (Human)	201	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20133869, ECO:0000269|PubMed:9371400}.		DNA damage response [GO:0006974]; ISG15-protein conjugation [GO:0032020]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]	nucleus [GO:0005634]	ATP binding [GO:0005524]; ISG15 transferase activity [GO:0042296]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	nucleus [GO:0005634]; ATP binding [GO:0005524]; ISG15 transferase activity [GO:0042296]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; DNA damage response [GO:0006974]; ISG15-protein conjugation [GO:0032020]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]	
Q96LT4	reviewed	SAMD8_HUMAN	Sphingomyelin synthase-related protein 1 (SMSr) (EC 2.7.8.-) (Ceramide phosphoethanolamine synthase) (CPE synthase) (Sterile alpha motif domain-containing protein 8) (SAM domain-containing protein 8)	SAMD8	Homo sapiens (Human)	415	FUNCTION: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. {ECO:0000269|PubMed:19506037}.		ceramide biosynthetic process [GO:0046513]; ceramide phosphoethanolamine biosynthetic process [GO:1905373]; regulation of ceramide biosynthetic process [GO:2000303]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	ceramide cholinephosphotransferase activity [GO:0047493]; ceramide phosphoethanolamine synthase activity [GO:0002950]; sphingomyelin synthase activity [GO:0033188]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; ceramide cholinephosphotransferase activity [GO:0047493]; ceramide phosphoethanolamine synthase activity [GO:0002950]; sphingomyelin synthase activity [GO:0033188]; ceramide biosynthetic process [GO:0046513]; ceramide phosphoethanolamine biosynthetic process [GO:1905373]; regulation of ceramide biosynthetic process [GO:2000303]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19506037}; Multi-pass membrane protein {ECO:0000269|PubMed:19506037}.
Q96LT7	reviewed	CI072_HUMAN	Guanine nucleotide exchange factor C9orf72	C9orf72 DENND9 DENNL72	Homo sapiens (Human)	481	FUNCTION: Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and modulating its protein kinase activity (PubMed:27617292). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ULK1/ATG1 kinase complex to the phagophore which leads to autophagosome formation (PubMed:27334615). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131). Plays a role in endosomal trafficking (PubMed:24549040). May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Promotes the lysosomal localization and lysosome-mediated degradation of CARM1 which leads to inhibition of starvation-induced lipid metabolism (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to CFL1/cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Required for SMCR8 protein expression and localization at pre- and post-synaptic compartments in the forebrain, also regulates protein abundance of RAB3A and GRIA1/GLUR1 in post-synaptic compartments in the forebrain and hippocampus (By similarity). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (By similarity). {ECO:0000250|UniProtKB:Q6DFW0, ECO:0000269|PubMed:24549040, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27334615, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:27723745, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}.; FUNCTION: [Isoform 1]: Regulates stress granule assembly in response to cellular stress. {ECO:0000269|PubMed:27037575}.; FUNCTION: [Isoform 2]: Does not play a role in regulation of stress granule assembly in response to cellular stress. {ECO:0000269|PubMed:27037575}.	MISCELLANEOUS: [Isoform 1]: Encoded by 2 transcripts differing in the 5' non-coding region.	autophagy [GO:0006914]; axon extension [GO:0048675]; endocytosis [GO:0006897]; late endosome to lysosome transport [GO:1902774]; negative regulation of exocytosis [GO:0045920]; negative regulation of immune response [GO:0050777]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of GTPase activity [GO:0043547]; positive regulation of macroautophagy [GO:0016239]; regulation of actin filament organization [GO:0110053]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of protein localization [GO:0032880]; regulation of TORC1 signaling [GO:1903432]; stress granule assembly [GO:0034063]	autophagosome [GO:0005776]; axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extracellular space [GO:0005615]; Flemming body [GO:0090543]; guanyl-nucleotide exchange factor complex [GO:0032045]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; main axon [GO:0044304]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; P-body [GO:0000932]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; presynapse [GO:0098793]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	autophagosome [GO:0005776]; axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extracellular space [GO:0005615]; Flemming body [GO:0090543]; guanyl-nucleotide exchange factor complex [GO:0032045]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; main axon [GO:0044304]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; P-body [GO:0000932]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; presynapse [GO:0098793]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; autophagy [GO:0006914]; axon extension [GO:0048675]; endocytosis [GO:0006897]; late endosome to lysosome transport [GO:1902774]; negative regulation of exocytosis [GO:0045920]; negative regulation of immune response [GO:0050777]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of GTPase activity [GO:0043547]; positive regulation of macroautophagy [GO:0016239]; regulation of actin filament organization [GO:0110053]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of protein localization [GO:0032880]; regulation of TORC1 signaling [GO:1903432]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21944779, ECO:0000269|PubMed:27037575}. Cytoplasm {ECO:0000269|PubMed:21944778, ECO:0000269|PubMed:27037575, ECO:0000269|PubMed:27193190}. Cytoplasm, P-body {ECO:0000269|PubMed:27037575}. Cytoplasm, Stress granule {ECO:0000269|PubMed:27037575}. Endosome {ECO:0000269|PubMed:24549040}. Lysosome {ECO:0000269|PubMed:24549040, ECO:0000269|PubMed:27559131}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24549040}. Secreted {ECO:0000269|PubMed:24549040}. Cell projection, axon {ECO:0000269|PubMed:27723745}. Cell projection, growth cone {ECO:0000269|PubMed:27723745}. Perikaryon {ECO:0000250|UniProtKB:Q6DFW0}. Note=Detected in the cytoplasm of neurons from brain tissue (PubMed:21944778). Detected in the nucleus in fibroblasts (PubMed:21944779). During corticogenesis, transitions from being predominantly cytoplasmic to a more even nucleocytoplasmic distribution (By similarity). {ECO:0000250|UniProtKB:Q6DFW0, ECO:0000269|PubMed:21944778, ECO:0000269|PubMed:21944779, ECO:0000269|PubMed:27037575}.; SUBCELLULAR LOCATION: [Isoform 1]: Perikaryon {ECO:0000269|PubMed:26174152}. Cell projection, dendrite {ECO:0000269|PubMed:26174152}. Presynapse {ECO:0000250|UniProtKB:Q6DFW0}. Postsynapse {ECO:0000250|UniProtKB:Q6DFW0}. Note=Expressed diffusely throughout the cytoplasm and dendritic processes of cerebellar Purkinje cells. Also expressed diffusely throughout the cytoplasm of spinal motor neurons. {ECO:0000269|PubMed:26174152}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus membrane {ECO:0000269|PubMed:26174152}; Peripheral membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:26174152}. Note=Detected at the nuclear membrane of cerebellar Purkinje cells and spinal motor neurons. Also shows diffuse nuclear expression in spinal motor neurons. {ECO:0000269|PubMed:26174152}.
Q96LT9	reviewed	RNPC3_HUMAN	RNA-binding region-containing protein 3 (RNA-binding motif protein 40) (RNA-binding protein 40) (U11/U12 small nuclear ribonucleoprotein 65 kDa protein) (U11/U12 snRNP 65 kDa protein) (U11/U12-65K)	RNPC3 KIAA1839 RBM40 RNP SNRNP65	Homo sapiens (Human)	517	FUNCTION: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. {ECO:0000269|PubMed:16096647, ECO:0000269|PubMed:19447915, ECO:0000269|PubMed:24480542, ECO:0000269|PubMed:29255062}.		mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type spliceosomal complex [GO:0005689]	pre-mRNA intronic binding [GO:0097157]; U12 snRNA binding [GO:0030626]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type spliceosomal complex [GO:0005689]; pre-mRNA intronic binding [GO:0097157]; U12 snRNA binding [GO:0030626]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14974681}.
Q96LW4	reviewed	PRIPO_HUMAN	DNA-directed primase/polymerase protein (hPrimpol1) (EC 2.7.7.-) (Coiled-coil domain-containing protein 111)	PRIMPOL CCDC111	Homo sapiens (Human)	560	FUNCTION: DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them (PubMed:24126761, PubMed:24207056, PubMed:24240614, PubMed:24267451, PubMed:25255211, PubMed:24682820, PubMed:25262353, PubMed:25746449, PubMed:25550423, PubMed:27989484, PubMed:29608762, PubMed:30889508, PubMed:28534480). Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions (PubMed:24126761, PubMed:24207056, PubMed:24240614, PubMed:24267451, PubMed:25255211, PubMed:24682820, PubMed:25262353, PubMed:25746449, PubMed:25550423, PubMed:27989484, PubMed:29608762, PubMed:30889508, PubMed:30633872, PubMed:28534480). Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (PubMed:24126761, PubMed:24207056, PubMed:24240614, PubMed:24267451, PubMed:25746449). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as ultraviolet (UV) lesions, R-loops and G-quadruplexes, to allow DNA replication to continue (PubMed:24240614, PubMed:26626482, PubMed:28534480, PubMed:30478192). Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion (PubMed:25746449). Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase (PubMed:24207056, PubMed:25255211, PubMed:25746449). Also required for reinitiating stalled forks after UV damage during nuclear DNA replication (PubMed:24240614). Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides (PubMed:24207056). Prevents APOBEC family-mediated DNA mutagenesis by repriming downstream of abasic site to prohibit error-prone translesion synthesis (By similarity). Has non-overlapping function with POLH (PubMed:24240614). In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (PubMed:30715459). {ECO:0000250|UniProtKB:Q6P1E7, ECO:0000269|PubMed:24126761, ECO:0000269|PubMed:24207056, ECO:0000269|PubMed:24240614, ECO:0000269|PubMed:24267451, ECO:0000269|PubMed:24682820, ECO:0000269|PubMed:25255211, ECO:0000269|PubMed:25262353, ECO:0000269|PubMed:25550423, ECO:0000269|PubMed:25746449, ECO:0000269|PubMed:26626482, ECO:0000269|PubMed:27989484, ECO:0000269|PubMed:28534480, ECO:0000269|PubMed:29608762, ECO:0000269|PubMed:30478192, ECO:0000269|PubMed:30633872, ECO:0000269|PubMed:30715459, ECO:0000269|PubMed:30889508}.; FUNCTION: Involved in adaptive response to cisplatin, a chemotherapeutic that causes reversal of replication forks, in cancer cells: reinitiates DNA synthesis past DNA lesions in BRCA1-deficient cancer cells treated with cisplatin via its de novo priming activity (PubMed:31676232). Repriming rescues fork degradation while leading to accumulation of internal ssDNA gaps behind the forks (PubMed:31676232). ATR regulates adaptive response to cisplatin (PubMed:31676232). {ECO:0000269|PubMed:31676232}.		error-prone translesion synthesis [GO:0042276]; mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; R-loop processing [GO:0062176]; replication fork processing [GO:0031297]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]	DNA-directed RNA polymerase complex [GO:0000428]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; replication fork [GO:0005657]	chromatin binding [GO:0003682]; DNA primase activity [GO:0003896]; DNA-directed DNA polymerase activity [GO:0003887]; manganese ion binding [GO:0030145]; zinc ion binding [GO:0008270]	DNA-directed RNA polymerase complex [GO:0000428]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; replication fork [GO:0005657]; chromatin binding [GO:0003682]; DNA primase activity [GO:0003896]; DNA-directed DNA polymerase activity [GO:0003887]; manganese ion binding [GO:0030145]; zinc ion binding [GO:0008270]; error-prone translesion synthesis [GO:0042276]; mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; R-loop processing [GO:0062176]; replication fork processing [GO:0031297]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24207056, ECO:0000269|PubMed:24240614}. Mitochondrion matrix {ECO:0000269|PubMed:24207056}. Chromosome {ECO:0000269|PubMed:28534480}. Note=Present in the nucleus, but a larger fraction is localized inside mitochondria (PubMed:24207056). Associates with nuclear chromatin during the G1 and S phases of unperturbed cell cycles (PubMed:24207056). Recruited to stalled replication forks following interaction with RPA1 (PubMed:28534480). {ECO:0000269|PubMed:24207056, ECO:0000269|PubMed:28534480}.
Q96LW7	reviewed	CAR19_HUMAN	Caspase recruitment domain-containing protein 19 (Bcl10-interacting CARD protein) (BinCARD)	CARD19 C9orf89	Homo sapiens (Human)	228	FUNCTION: Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. {ECO:0000269|PubMed:15637807}.	MISCELLANEOUS: [Isoform 2]: Appears to be the dominant isoform in peripheral blood cell fractions. Contains a transmembrane helix. {ECO:0000305}.	negative regulation of canonical NF-kappaB signal transduction [GO:0043124]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	CARD domain binding [GO:0050700]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; CARD domain binding [GO:0050700]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:23633586}. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23633586}; Single-pass membrane protein {ECO:0000269|PubMed:23633586}. Mitochondrion membrane {ECO:0000269|PubMed:23633586}; Single-pass membrane protein {ECO:0000269|PubMed:23633586}.
Q96LX7	reviewed	CCD17_HUMAN	Coiled-coil domain-containing protein 17	CCDC17	Homo sapiens (Human)	622		MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q96LX8	reviewed	ZN597_HUMAN	Zinc finger protein 597	ZNF597	Homo sapiens (Human)	424	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96LZ3	reviewed	CANB2_HUMAN	Calcineurin subunit B type 2 (Calcineurin B-like protein) (CBLP) (Calcineurin BII) (CNBII) (PPP3R1-like) (Protein phosphatase 2B regulatory subunit 2) (Protein phosphatase 3 regulatory subunit B beta isoform)	PPP3R2 CBLP PPP3RL	Homo sapiens (Human)	170	FUNCTION: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. {ECO:0000250|UniProtKB:P63098}.	MISCELLANEOUS: This protein has four functional calcium-binding sites. {ECO:0000250|UniProtKB:P63098}.	calcineurin-mediated signaling [GO:0097720]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; penetration of zona pellucida [GO:0007341]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]	calcineurin complex [GO:0005955]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; protein serine/threonine phosphatase complex [GO:0008287]; sperm mitochondrial sheath [GO:0097226]	calcium ion binding [GO:0005509]; calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; phosphatase binding [GO:0019902]	calcineurin complex [GO:0005955]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; protein serine/threonine phosphatase complex [GO:0008287]; sperm mitochondrial sheath [GO:0097226]; calcium ion binding [GO:0005509]; calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; phosphatase binding [GO:0019902]; calcineurin-mediated signaling [GO:0097720]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; penetration of zona pellucida [GO:0007341]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q63811}. Note=Localizes in the mitochondria in a SPATA33-dependent manner. {ECO:0000250|UniProtKB:Q63811}.
Q96LZ7	reviewed	RMD2_HUMAN	Regulator of microtubule dynamics protein 2 (RMD-2) (hRMD-2) (Protein FAM82A1)	RMDN2 FAM82A FAM82A1 BLOCK18 UNQ9371/PRO34163	Homo sapiens (Human)	410				cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; spindle microtubule [GO:0005876]	microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; spindle microtubule [GO:0005876]; microtubule binding [GO:0008017]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18070910}. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Also detected as large dots in the perinuclear region.
Q96M02	reviewed	CJ090_HUMAN	(E2-independent) E3 ubiquitin-conjugating enzyme FATS (EC 2.3.2.-) (Centrosomal protein C10orf90) (E2/E3 hybrid ubiquitin-protein ligase FATS) (Fragile-site associated tumor suppressor homolog) (FATS)	C10orf90 FATS	Homo sapiens (Human)	699	FUNCTION: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity). May have a role in the assembly of primary cilia (Probable). {ECO:0000250|UniProtKB:D2J0Y4, ECO:0000305|PubMed:20844083}.		protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of centriole replication [GO:0046599]	actin cytoskeleton [GO:0015629]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	microtubule binding [GO:0008017]; ubiquitin protein ligase activity [GO:0061630]	actin cytoskeleton [GO:0015629]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; microtubule binding [GO:0008017]; ubiquitin protein ligase activity [GO:0061630]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of centriole replication [GO:0046599]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20844083}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20844083}. Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin. {ECO:0000269|PubMed:20844083}.
Q96M11	reviewed	HYLS1_HUMAN	Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1)	HYLS1 HLS	Homo sapiens (Human)	299	FUNCTION: Plays a role in ciliogenesis. {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}.		cilium assembly [GO:0060271]	centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15843405}. Cell projection, cilium {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}.
Q96M29	reviewed	TEKT5_HUMAN	Tektin-5	TEKT5	Homo sapiens (Human)	485	FUNCTION: May be a structural component of the sperm flagellum. {ECO:0000250|UniProtKB:G5E8A8}.		cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]	microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]		microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:G5E8A8}. Note=Appears to be associated with flagellar accessory structures and not the axoneme. {ECO:0000250|UniProtKB:G5E8A8}.
Q96M32	reviewed	KAD7_HUMAN	Adenylate kinase 7 (AK 7) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 7)	AK7	Homo sapiens (Human)	723	FUNCTION: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function. {ECO:0000269|PubMed:21080915, ECO:0000269|PubMed:23416111}.		cell projection organization [GO:0030030]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; motile cilium [GO:0031514]	adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; cytidylate kinase activity [GO:0004127]; nucleoside diphosphate kinase activity [GO:0004550]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; motile cilium [GO:0031514]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; cytidylate kinase activity [GO:0004127]; nucleoside diphosphate kinase activity [GO:0004550]; cell projection organization [GO:0030030]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21080915}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:29365104}. Note=Detected along the full length of sperm flagellum, where it colocalizes with alpha-tubulin. {ECO:0000269|PubMed:29365104}.
Q96M61	reviewed	MAGBI_HUMAN	Melanoma-associated antigen B18 (MAGE-B18 antigen)	MAGEB18	Homo sapiens (Human)	343	FUNCTION: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BQR7}.
Q96M63	reviewed	ODAD1_HUMAN	Outer dynein arm-docking complex subunit 1 (Coiled-coil domain-containing protein 114)	ODAD1 CCDC114	Homo sapiens (Human)	670	FUNCTION: Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). {ECO:0000250|UniProtKB:F1N2N9, ECO:0000269|PubMed:27486780, ECO:0000305|PubMed:23261302, ECO:0000305|PubMed:23261303}.		cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]	axoneme [GO:0005930]; cilium [GO:0005929]; outer dynein arm [GO:0036157]; outer dynein arm docking complex [GO:0120228]		axoneme [GO:0005930]; cilium [GO:0005929]; outer dynein arm [GO:0036157]; outer dynein arm docking complex [GO:0120228]; cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23261303, ECO:0000269|PubMed:25192045}.
Q96M86	reviewed	DNHD1_HUMAN	Dynein heavy chain domain-containing protein 1 (Coiled-coil domain-containing protein 35) (Dynein heavy chain domain 1-like protein)	DNHD1 C11orf47 CCDC35 DHCD1 DNHD1L UNQ5781/PRO12970	Homo sapiens (Human)	4753	FUNCTION: Essential for the normal assembly and function of sperm flagella axonemes. {ECO:0000305|PubMed:34932939}.		flagellated sperm motility [GO:0030317]; sperm flagellum assembly [GO:0120316]	extracellular exosome [GO:0070062]; inner dynein arm [GO:0036156]; sperm flagellum [GO:0036126]	ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]	extracellular exosome [GO:0070062]; inner dynein arm [GO:0036156]; sperm flagellum [GO:0036126]; ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; flagellated sperm motility [GO:0030317]; sperm flagellum assembly [GO:0120316]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:34932939}. Note=Predominantly concentrated in the mid-piece of the sperm flagella. {ECO:0000269|PubMed:34932939}.
Q96M91	reviewed	CFA53_HUMAN	Cilia- and flagella-associated protein 53 (Coiled-coil domain-containing protein 11)	CFAP53 CCDC11	Homo sapiens (Human)	514	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis (PubMed:26531781). {ECO:0000250|UniProtKB:F1N7G5, ECO:0000269|PubMed:26531781, ECO:0000269|PubMed:36191189}.		cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]	axonemal microtubule [GO:0005879]; extracellular region [GO:0005576]		axonemal microtubule [GO:0005879]; extracellular region [GO:0005576]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q96M94	reviewed	KLH15_HUMAN	Kelch-like protein 15	KLHL15 KIAA1677	Homo sapiens (Human)	604	FUNCTION: Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:27561354, PubMed:14528312, PubMed:35219381). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation (PubMed:27561354, PubMed:35219381). Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354, PubMed:35219381). {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:23135275, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:35219381}.		negative regulation of double-strand break repair via homologous recombination [GO:2000042]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	Cul3-RING ubiquitin ligase complex [GO:0031463]; nucleus [GO:0005634]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; nucleus [GO:0005634]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27561354}.
Q96M96	reviewed	FGD4_HUMAN	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6)	FGD4 FRABP ZFYVE6	Homo sapiens (Human)	766	FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:15133042}.		actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726]	actin binding [GO:0003779]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726]; actin binding [GO:0003779]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). {ECO:0000250}.
Q96M98	reviewed	PACRG_HUMAN	Parkin coregulated gene protein (Molecular chaperone/chaperonin-binding protein) (PARK2 coregulated gene protein)	PACRG GLUP	Homo sapiens (Human)	296	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease (PubMed:14532270). {ECO:0000250|UniProtKB:A5PK71, ECO:0000269|PubMed:14532270, ECO:0000269|PubMed:36191189}.	MISCELLANEOUS: Linked to PRKN in a head-to-head arrangement on opposite DNA strands and share a common 5'-flanking promoter region.; MISCELLANEOUS: [Isoform 2]: May be due to exon skipping. {ECO:0000305}.	cellular response to unfolded protein [GO:0034620]; protein localization [GO:0008104]; spermatid development [GO:0007286]	axonemal microtubule [GO:0005879]; cell body [GO:0044297]; cytosol [GO:0005829]; manchette [GO:0002177]; neuron projection [GO:0043005]; nucleus [GO:0005634]; sperm midpiece [GO:0097225]; vesicle [GO:0031982]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625]	axonemal microtubule [GO:0005879]; cell body [GO:0044297]; cytosol [GO:0005829]; manchette [GO:0002177]; neuron projection [GO:0043005]; nucleus [GO:0005634]; sperm midpiece [GO:0097225]; vesicle [GO:0031982]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625]; cellular response to unfolded protein [GO:0034620]; protein localization [GO:0008104]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q96MA6	reviewed	KAD8_HUMAN	Adenylate kinase 8 (AK 8) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 8)	AK8 C9orf98	Homo sapiens (Human)	479	FUNCTION: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:21080915, ECO:0000269|PubMed:23416111}.		phosphorylation [GO:0016310]; ventricular system development [GO:0021591]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; sperm flagellum [GO:0036126]	adenylate kinase activity [GO:0004017]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; cytidylate kinase activity [GO:0004127]; nucleoside diphosphate kinase activity [GO:0004550]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; sperm flagellum [GO:0036126]; adenylate kinase activity [GO:0004017]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; cytidylate kinase activity [GO:0004127]; nucleoside diphosphate kinase activity [GO:0004550]; phosphorylation [GO:0016310]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21080915}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:33139725}. Note=Located in the proximal region of respiratory cilia. {ECO:0000269|PubMed:33139725}.
Q96MC2	reviewed	DRC1_HUMAN	Dynein regulatory complex protein 1 (Coiled-coil domain-containing protein 164)	DRC1 C2orf39 CCDC164	Homo sapiens (Human)	740	FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes (PubMed:23354437, PubMed:34169321). Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:23354437). {ECO:0000250|UniProtKB:P0DL09, ECO:0000269|PubMed:23354437, ECO:0000269|PubMed:34169321}.		axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; regulation of cilium movement [GO:0003352]	axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; cytosol [GO:0005829]; motile cilium [GO:0031514]		axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; cytosol [GO:0005829]; motile cilium [GO:0031514]; axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; regulation of cilium movement [GO:0003352]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:P0DL09}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:P0DL09}.
Q96MD2	reviewed	KICS2_HUMAN	KICSTOR subunit 2 (KICSTOR complex protein C12orf66)	KICS2 C12orf66	Homo sapiens (Human)	445	FUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000269|PubMed:28199306}.		cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; negative regulation of TORC1 signaling [GO:1904262]; protein localization to lysosome [GO:0061462]	intercellular bridge [GO:0045171]; KICSTOR complex [GO:0140007]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]		intercellular bridge [GO:0045171]; KICSTOR complex [GO:0140007]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; negative regulation of TORC1 signaling [GO:1904262]; protein localization to lysosome [GO:0061462]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000305|PubMed:28199306}.
Q96MF2	reviewed	STAC3_HUMAN	SH3 and cysteine-rich domain-containing protein 3	STAC3	Homo sapiens (Human)	364	FUNCTION: Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335). Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:29078335). {ECO:0000250|UniProtKB:Q8BZ71, ECO:0000269|PubMed:23736855, ECO:0000269|PubMed:29078335}.		neuromuscular synaptic transmission [GO:0007274]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; skeletal muscle contraction [GO:0003009]; skeletal muscle fiber development [GO:0048741]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nucleoplasm [GO:0005654]; synapse [GO:0045202]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nucleoplasm [GO:0005654]; synapse [GO:0045202]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; skeletal muscle contraction [GO:0003009]; skeletal muscle fiber development [GO:0048741]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BZ71}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q8BZ71}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8BZ71}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8BZ71}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:Q8BZ71}. Note=Co-localizes with CACNA1S and CACNA1C on T-tubules. {ECO:0000250|UniProtKB:Q8BZ71}.
Q96MF7	reviewed	NSE2_HUMAN	E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog)	NSMCE2 C8orf36 MMS21	Homo sapiens (Human)	247	FUNCTION: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination (PubMed:16055714, PubMed:16810316). Is not be required for the stability of the complex (PubMed:16055714, PubMed:16810316). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (PubMed:16055714, PubMed:16810316). The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) (PubMed:17589526). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 (PubMed:16055714, PubMed:16810316, PubMed:17589526, PubMed:31400850). Required for recruitment of telomeres to PML nuclear bodies (PubMed:17589526). SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines (PubMed:17589526). Required for sister chromatid cohesion during prometaphase and mitotic progression (PubMed:19502785). {ECO:0000269|PubMed:16055714, ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:31400850}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cellular senescence [GO:0090398]; chromatin looping [GO:0140588]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]; telomere maintenance via recombination [GO:0000722]	chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; Smc5-Smc6 complex [GO:0030915]	SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; zinc ion binding [GO:0008270]	chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; Smc5-Smc6 complex [GO:0030915]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular senescence [GO:0090398]; chromatin looping [GO:0140588]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]; telomere maintenance via recombination [GO:0000722]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000269|PubMed:17589526}. Nucleus, PML body {ECO:0000269|PubMed:17589526}. Note=Localizes to PML nuclear bodies in ALT cell lines. {ECO:0000269|PubMed:17589526}.
Q96MG2	reviewed	JSPR1_HUMAN	Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45)	JSRP1 JP45	Homo sapiens (Human)	331	FUNCTION: Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}.		skeletal muscle contraction [GO:0003009]	sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]		sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; skeletal muscle contraction [GO:0003009]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes. {ECO:0000250}.
Q96MG7	reviewed	NSE3_HUMAN	Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2)	NSMCE3 HCA4 MAGEG1 NDNL2	Homo sapiens (Human)	304	FUNCTION: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). {ECO:0000250|UniProtKB:Q9CPR8, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:27427983}.		cellular response to hydroxyurea [GO:0072711]; cellular response to radiation [GO:0071478]; cellular response to UV [GO:0034644]; chromatin looping [GO:0140588]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein ubiquitination [GO:0031398]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]	protein dimerization activity [GO:0046983]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]; protein dimerization activity [GO:0046983]; cellular response to hydroxyurea [GO:0072711]; cellular response to radiation [GO:0071478]; cellular response to UV [GO:0034644]; chromatin looping [GO:0140588]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein ubiquitination [GO:0031398]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000305|PubMed:18086888}.
Q96MG8	reviewed	PCMD1_HUMAN	Protein-L-isoaspartate O-methyltransferase domain-containing protein 1	PCMTD1	Homo sapiens (Human)	357	FUNCTION: Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35486881). Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity (PubMed:35486881). May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein (PubMed:35486881). {ECO:0000269|PubMed:35486881}.		protein ubiquitination [GO:0016567]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; membrane [GO:0016020]	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; membrane [GO:0016020]; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P22061}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Q96MH2	reviewed	HEXI2_HUMAN	Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2)	HEXIM2 L3	Homo sapiens (Human)	286	FUNCTION: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}.		negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	7SK snRNA binding [GO:0097322]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; snRNA binding [GO:0017069]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 7SK snRNA binding [GO:0097322]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; snRNA binding [GO:0017069]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15994294}.
Q96MI9	reviewed	CBPC4_HUMAN	Cytosolic carboxypeptidase 4 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 1) (Protein deglutamylase CCP4)	AGBL1 CCP4	Homo sapiens (Human)	1112	FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. {ECO:0000250|UniProtKB:Q09M05}.		C-terminal protein deglutamylation [GO:0035609]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]	cytosol [GO:0005829]	metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]; C-terminal protein deglutamylation [GO:0035609]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24094747}.
Q96MK3	reviewed	FA20A_HUMAN	Pseudokinase FAM20A	FAM20A UNQ9388/PRO34279	Homo sapiens (Human)	541	FUNCTION: Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. {ECO:0000269|PubMed:25789606}.		biomineral tissue development [GO:0031214]; calcium ion homeostasis [GO:0055074]; enamel mineralization [GO:0070166]; positive regulation of protein phosphorylation [GO:0001934]; response to bacterium [GO:0009617]; tooth eruption [GO:0044691]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]	protein serine/threonine kinase activator activity [GO:0043539]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; protein serine/threonine kinase activator activity [GO:0043539]; biomineral tissue development [GO:0031214]; calcium ion homeostasis [GO:0055074]; enamel mineralization [GO:0070166]; positive regulation of protein phosphorylation [GO:0001934]; response to bacterium [GO:0009617]; tooth eruption [GO:0044691]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8CID3}. Golgi apparatus {ECO:0000269|PubMed:23468644}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8CID3}.
Q96MM3	reviewed	ZFP42_HUMAN	Zinc finger protein 42 homolog (Zfp-42) (Reduced expression protein 1) (REX-1) (hREX-1) (Zinc finger protein 754)	ZFP42 REX1 ZNF754	Homo sapiens (Human)	310	FUNCTION: Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity). {ECO:0000250}.		female gonad development [GO:0008585]; male gonad development [GO:0008584]; meiotic cell cycle [GO:0051321]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; female gonad development [GO:0008585]; male gonad development [GO:0008584]; meiotic cell cycle [GO:0051321]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96MM7	reviewed	H6ST2_HUMAN	Heparan-sulfate 6-O-sulfotransferase 2 (HS6ST-2) (EC 2.8.2.-)	HS6ST2 PSEC0092	Homo sapiens (Human)	605	FUNCTION: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. {ECO:0000269|PubMed:12492399, ECO:0000269|PubMed:30471091}.		heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	Golgi membrane [GO:0000139]	heparan sulfate 6-O-sulfotransferase activity [GO:0017095]	Golgi membrane [GO:0000139]; heparan sulfate 6-O-sulfotransferase activity [GO:0017095]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q96MN2	reviewed	NALP4_HUMAN	NACHT, LRR and PYD domains-containing protein 4 (Cancer/testis antigen 58) (CT58) (PAAD and NACHT-containing protein 2) (PAN2) (PYRIN and NACHT-containing protein 2) (PYRIN-containing APAF1-like protein 4) (PYPAF4) (Ribonuclease inhibitor 2)	NLRP4 NALP4 PAN2 PYPAF4 RNH2	Homo sapiens (Human)	994	FUNCTION: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways. {ECO:0000269|PubMed:12093792, ECO:0000269|PubMed:22388039}.		inflammatory response [GO:0006954]; negative regulation of innate immune response [GO:0045824]; regulation of inflammatory response [GO:0050727]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; molecular adaptor activity [GO:0060090]; inflammatory response [GO:0006954]; negative regulation of innate immune response [GO:0045824]; regulation of inflammatory response [GO:0050727]	
Q96MN9	reviewed	ZN488_HUMAN	Zinc finger protein 488	ZNF488	Homo sapiens (Human)	340	FUNCTION: Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury. {ECO:0000250|UniProtKB:Q5HZG9}.		negative regulation of DNA-templated transcription [GO:0045892]; oligodendrocyte development [GO:0014003]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; negative regulation of DNA-templated transcription [GO:0045892]; oligodendrocyte development [GO:0014003]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5HZG9}.
Q96MP8	reviewed	KCTD7_HUMAN	BTB/POZ domain-containing protein KCTD7	KCTD7	Homo sapiens (Human)	289	FUNCTION: May be involved in the control of excitability of cortical neurons. {ECO:0000250}.		intracellular glutamate homeostasis [GO:0090461]; intracellular potassium ion homeostasis [GO:0030007]; membrane hyperpolarization [GO:0060081]; protein homooligomerization [GO:0051260]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; intracellular glutamate homeostasis [GO:0090461]; intracellular potassium ion homeostasis [GO:0030007]; membrane hyperpolarization [GO:0060081]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Cell membrane. Cytoplasm, cytosol.
Q96MS0	reviewed	ROBO3_HUMAN	Roundabout homolog 3 (Roundabout-like protein 3)	ROBO3	Homo sapiens (Human)	1386	FUNCTION: Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube (By similarity). In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing (PubMed:15105459). {ECO:0000250|UniProtKB:Q9Z2I4, ECO:0000269|PubMed:15105459}.		axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of axon guidance [GO:1902669]	axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cell-cell adhesion mediator activity [GO:0098632]	axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cell-cell adhesion mediator activity [GO:0098632]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of axon guidance [GO:1902669]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9Z2I4}; Single-pass type I membrane protein {ECO:0000255}.
Q96MT3	reviewed	PRIC1_HUMAN	Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1)	PRICKLE1 RILP	Homo sapiens (Human)	831	FUNCTION: Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. {ECO:0000269|PubMed:21901791}.		anterior visceral endoderm cell migration [GO:1905070]; aorta development [GO:0035904]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; basement membrane organization [GO:0071711]; bone mineralization [GO:0030282]; cardiac muscle cell development [GO:0055013]; cell-cell adhesion [GO:0098609]; cilium assembly [GO:0060271]; cornea development in camera-type eye [GO:0061303]; coronary vasculature development [GO:0060976]; cytoskeleton-dependent intracellular transport [GO:0030705]; dendrite development [GO:0016358]; embryonic brain development [GO:1990403]; embryonic nail plate morphogenesis [GO:0035880]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of bipolar cell polarity involved in cell morphogenesis [GO:0061159]; extracellular matrix assembly [GO:0085029]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; focal adhesion disassembly [GO:0120181]; gene expression [GO:0010467]; mesenchyme development [GO:0060485]; mitotic spindle assembly [GO:0090307]; multicellular organism growth [GO:0035264]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell myoblast differentiation [GO:2000691]; negative regulation of DNA-templated transcription [GO:0045892]; neural tube closure [GO:0001843]; neuron projection extension [GO:1990138]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in axis elongation [GO:0003402]; polarized secretion of basement membrane proteins in epithelium [GO:0061865]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein import into nucleus [GO:0006606]; renal tubule development [GO:0061326]; response to electrical stimulus [GO:0051602]; response to xenobiotic stimulus [GO:0009410]; tear secretion [GO:0070075]; tissue homeostasis [GO:0001894]; vesicle-mediated transport [GO:0016192]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	cell trailing edge [GO:0031254]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; proteasome complex [GO:0000502]	protein-containing complex binding [GO:0044877]; zinc ion binding [GO:0008270]	cell trailing edge [GO:0031254]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; protein-containing complex binding [GO:0044877]; zinc ion binding [GO:0008270]; anterior visceral endoderm cell migration [GO:1905070]; aorta development [GO:0035904]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; basement membrane organization [GO:0071711]; bone mineralization [GO:0030282]; cardiac muscle cell development [GO:0055013]; cell-cell adhesion [GO:0098609]; cilium assembly [GO:0060271]; cornea development in camera-type eye [GO:0061303]; coronary vasculature development [GO:0060976]; cytoskeleton-dependent intracellular transport [GO:0030705]; dendrite development [GO:0016358]; embryonic brain development [GO:1990403]; embryonic nail plate morphogenesis [GO:0035880]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of bipolar cell polarity involved in cell morphogenesis [GO:0061159]; extracellular matrix assembly [GO:0085029]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; focal adhesion disassembly [GO:0120181]; gene expression [GO:0010467]; mesenchyme development [GO:0060485]; mitotic spindle assembly [GO:0090307]; multicellular organism growth [GO:0035264]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell myoblast differentiation [GO:2000691]; negative regulation of DNA-templated transcription [GO:0045892]; neural tube closure [GO:0001843]; neuron projection extension [GO:1990138]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in axis elongation [GO:0003402]; polarized secretion of basement membrane proteins in epithelium [GO:0061865]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein import into nucleus [GO:0006606]; renal tubule development [GO:0061326]; response to electrical stimulus [GO:0051602]; response to xenobiotic stimulus [GO:0009410]; tear secretion [GO:0070075]; tissue homeostasis [GO:0001894]; vesicle-mediated transport [GO:0016192]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:14645515}. Cytoplasm, cytosol {ECO:0000269|PubMed:14645515}. Note=A smaller amount is detected in the cytosol.
Q96MT7	reviewed	CFA44_HUMAN	Cilia- and flagella-associated protein 44 (WD repeat-containing protein 52)	CFAP44 WDR52	Homo sapiens (Human)	1854	FUNCTION: Flagellar protein involved in sperm flagellum axoneme organization and function. {ECO:0000250|UniProtKB:E9Q5M6}.		microtubule cytoskeleton organization [GO:0000226]; sperm axoneme assembly [GO:0007288]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]	peptidase activity [GO:0008233]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; peptidase activity [GO:0008233]; microtubule cytoskeleton organization [GO:0000226]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A8J1V4}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q57WH1}.
Q96MT8	reviewed	CEP63_HUMAN	Centrosomal protein of 63 kDa (Cep63)	CEP63	Homo sapiens (Human)	703	FUNCTION: Required for normal spindle assembly (PubMed:21406398, PubMed:21983783, PubMed:26297806, PubMed:35793002). Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:21983783, PubMed:26297806). Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response (PubMed:21406398). Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398). Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (PubMed:35989368). {ECO:0000269|PubMed:21406398, ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:35793002, ECO:0000269|PubMed:35989368}.	MISCELLANEOUS: CEP63 and DEUP1 paralogs are both involved in centriole amplification: while CEP63 mediates mother-centriole-dependent centriole duplication, DEUP1 mediates de novo centriole amplification in multiciliated cells.	cell division [GO:0051301]; centriole replication [GO:0007099]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; DNA damage checkpoint signaling [GO:0000077]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; protein stabilization [GO:0050821]; signal transduction in response to DNA damage [GO:0042770]; spindle assembly [GO:0051225]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; spindle pole [GO:0000922]	molecular adaptor activity [GO:0060090]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; spindle pole [GO:0000922]; molecular adaptor activity [GO:0060090]; cell division [GO:0051301]; centriole replication [GO:0007099]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; DNA damage checkpoint signaling [GO:0000077]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; protein stabilization [GO:0050821]; signal transduction in response to DNA damage [GO:0042770]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:32402286, ECO:0000269|PubMed:35793002}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:32402286}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:32402286}. Note=Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. {ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:32402286}.
Q96MU7	reviewed	YTDC1_HUMAN	YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)	YTHDC1 KIAA1966 YT521	Homo sapiens (Human)	727	FUNCTION: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}.		dosage compensation by inactivation of X chromosome [GO:0009048]; in utero embryonic development [GO:0001701]; mRNA alternative polyadenylation [GO:0110104]; mRNA export from nucleus [GO:0006406]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; post-transcriptional regulation of gene expression [GO:0010608]; primary follicle stage [GO:0048160]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; spermatogenesis [GO:0007283]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]; dosage compensation by inactivation of X chromosome [GO:0009048]; in utero embryonic development [GO:0001701]; mRNA alternative polyadenylation [GO:0110104]; mRNA export from nucleus [GO:0006406]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; post-transcriptional regulation of gene expression [GO:0010608]; primary follicle stage [GO:0048160]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20167602}. Nucleus speckle {ECO:0000269|PubMed:26876937}. Note=Localizes to a novel subnuclear structure, the YT bodies. {ECO:0000250|UniProtKB:Q9QY02}.
Q96MU8	reviewed	KREM1_HUMAN	Kremen protein 1 (Dickkopf receptor) (Kringle domain-containing transmembrane protein 1) (Kringle-containing protein marking the eye and the nose)	KREMEN1 KREMEN KRM1	Homo sapiens (Human)	473	FUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification. {ECO:0000250|UniProtKB:Q90Y90, ECO:0000250|UniProtKB:Q99N43}.	MISCELLANEOUS: [Isoform 1]: Exon 1 splicing donor site is not canonical.	apoptotic process [GO:0006915]; cell communication [GO:0007154]; limb development [GO:0060173]; negative regulation of axon regeneration [GO:0048681]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055]	membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]		membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; apoptotic process [GO:0006915]; cell communication [GO:0007154]; limb development [GO:0060173]; negative regulation of axon regeneration [GO:0048681]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q99N43}; Single-pass type I membrane protein {ECO:0000305}.
Q96MV1	reviewed	TLCD4_HUMAN	TLC domain-containing protein 4 (Transmembrane protein 56)	TLCD4 TMEM56	Homo sapiens (Human)	263			lipid homeostasis [GO:0055088]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]		endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; lipid homeostasis [GO:0055088]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96MV8	reviewed	ZDH15_HUMAN	Palmitoyltransferase ZDHHC15 (EC 2.3.1.225) (Acyltransferase ZDHHC15) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 15) (DHHC-15)	ZDHHC15 UNQ1969/PRO4501	Homo sapiens (Human)	337	FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:18817523, PubMed:23034182). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (PubMed:18817523). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (PubMed:18817523). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis (By similarity). Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity). Could also catalyze the palmitoylation of GAP43 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate FYN as shown in vitro (PubMed:19956733). {ECO:0000250|UniProtKB:F1QXD3, ECO:0000250|UniProtKB:Q8BGJ0, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:19956733, ECO:0000269|PubMed:23034182}.		peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of dendrite development [GO:1900006]; protein localization to membrane [GO:0072657]; protein localization to postsynapse [GO:0062237]; protein palmitoylation [GO:0018345]; protein targeting to Golgi apparatus [GO:0140450]; protein targeting to membrane [GO:0006612]; regulation of dendritic spine morphogenesis [GO:0061001]; synaptic vesicle maturation [GO:0016188]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; zinc ion binding [GO:0008270]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of dendrite development [GO:1900006]; protein localization to membrane [GO:0072657]; protein localization to postsynapse [GO:0062237]; protein palmitoylation [GO:0018345]; protein targeting to Golgi apparatus [GO:0140450]; protein targeting to membrane [GO:0006612]; regulation of dendritic spine morphogenesis [GO:0061001]; synaptic vesicle maturation [GO:0016188]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16647879}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F1QXD3}. Postsynaptic density {ECO:0000250|UniProtKB:Q2TGJ4}.
Q96MW5	reviewed	COG8_HUMAN	Conserved oligomeric Golgi complex subunit 8 (COG complex subunit 8) (Component of oligomeric Golgi complex 8)	COG8	Homo sapiens (Human)	612	FUNCTION: Required for normal Golgi function. {ECO:0000250}.		glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588]		Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588]; glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11703943}; Peripheral membrane protein {ECO:0000269|PubMed:11703943}.
Q96MX0	reviewed	CKLF3_HUMAN	CKLF-like MARVEL transmembrane domain-containing protein 3 (Chemokine-like factor superfamily member 3)	CMTM3 CKLFSF3	Homo sapiens (Human)	182			blastocyst hatching [GO:0001835]; chemotaxis [GO:0006935]; positive regulation of B cell receptor signaling pathway [GO:0050861]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nuclear membrane [GO:0031965]	cytokine activity [GO:0005125]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nuclear membrane [GO:0031965]; cytokine activity [GO:0005125]; blastocyst hatching [GO:0001835]; chemotaxis [GO:0006935]; positive regulation of B cell receptor signaling pathway [GO:0050861]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q96MX3	reviewed	ZNF48_HUMAN	Zinc finger protein 48 (Zinc finger protein 553)	ZNF48 ZNF553	Homo sapiens (Human)	618	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96MY7	reviewed	F161B_HUMAN	Protein FAM161B	FAM161B C14orf44	Homo sapiens (Human)	647			cilium organization [GO:0044782]	cytoplasmic microtubule [GO:0005881]; microtubule cytoskeleton [GO:0015630]		cytoplasmic microtubule [GO:0005881]; microtubule cytoskeleton [GO:0015630]; cilium organization [GO:0044782]	
Q96N16	reviewed	JKIP1_HUMAN	Janus kinase and microtubule-interacting protein 1 (GABA-B receptor-binding protein) (Multiple alpha-helices and RNA-linker protein 1) (Marlin-1)	JAKMIP1 GABABRBP JAMIP1 MARLIN1	Homo sapiens (Human)	626	FUNCTION: Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. {ECO:0000269|PubMed:14718537, ECO:0000269|PubMed:15277531, ECO:0000269|PubMed:17532644}.	MISCELLANEOUS: [Isoform 3]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.	cognition [GO:0050890]; protein transport [GO:0015031]	cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874]; ribonucleoprotein complex [GO:1990904]	GABA receptor binding [GO:0050811]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874]; ribonucleoprotein complex [GO:1990904]; GABA receptor binding [GO:0050811]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]; cognition [GO:0050890]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells.
Q96N19	reviewed	G137A_HUMAN	Integral membrane protein GPR137 (Transmembrane 7 superfamily member 1-like 1 protein)	GPR137 C11orf4 GPR137A TM7SF1L1	Homo sapiens (Human)	417	FUNCTION: Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes (PubMed:31036939). May play a role in autophagy (PubMed:31036939). {ECO:0000269|PubMed:31036939}.; FUNCTION: May activate Wnt/beta-catenin signaling to modulate epithelial cell function. {ECO:0000250|UniProtKB:Q80ZU9}.		autophagy [GO:0006914]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506]	lysosomal membrane [GO:0005765]		lysosomal membrane [GO:0005765]; autophagy [GO:0006914]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:31036939}; Multi-pass membrane protein {ECO:0000255}.
Q96N21	reviewed	AP4AT_HUMAN	AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin)	TEPSIN C17orf56 ENTHD2	Homo sapiens (Human)	525	FUNCTION: Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}.			coated vesicle membrane [GO:0030662]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of organelle membrane [GO:0031312]; intracellular membrane-bounded organelle [GO:0043231]; organelle membrane [GO:0031090]; trans-Golgi network membrane [GO:0032588]	protein-containing complex binding [GO:0044877]	coated vesicle membrane [GO:0030662]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of organelle membrane [GO:0031312]; intracellular membrane-bounded organelle [GO:0043231]; organelle membrane [GO:0031090]; trans-Golgi network membrane [GO:0032588]; protein-containing complex binding [GO:0044877]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:26542808, ECO:0000269|PubMed:26756312}; Peripheral membrane protein {ECO:0000269|PubMed:26756312}. Cytoplasmic vesicle {ECO:0000269|PubMed:22472443}. Cytoplasm, cytosol {ECO:0000269|PubMed:22472443}. Note=Extensively colocalizes with AP-4 which mediates the recruitment of TEPSIN to the trans-Golgi network. {ECO:0000269|PubMed:22472443, ECO:0000269|PubMed:26542808}.
Q96N58	reviewed	ZN578_HUMAN	Zinc finger protein 578	ZNF578	Homo sapiens (Human)	590	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96N64	reviewed	PWP2A_HUMAN	PWWP domain-containing protein 2A	PWWP2A KIAA1935 MST101	Homo sapiens (Human)	755	FUNCTION: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:28645917, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:30327463}.		chromatin remodeling [GO:0006338]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of transcriptional start site selection at RNA polymerase II promoter [GO:0001178]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; NuRD complex binding [GO:0120325]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; NuRD complex binding [GO:0120325]; chromatin remodeling [GO:0006338]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of transcriptional start site selection at RNA polymerase II promoter [GO:0001178]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28645917}.
Q96N66	reviewed	MBOA7_HUMAN	Lysophospholipid acyltransferase 7 (LPLAT 7) (EC 2.3.1.-) (1-acylglycerophosphatidylinositol O-acyltransferase) (Bladder and breast carcinoma-overexpressed gene 1 protein) (Leukocyte receptor cluster member 4) (Lysophosphatidylinositol acyltransferase) (LPIAT) (Lyso-PI acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 7) (O-acyltransferase domain-containing protein 7) (h-mboa-7)	MBOAT7 BB1 LENG4 OACT7	Homo sapiens (Human)	472	FUNCTION: Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128, PubMed:18094042). Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell (PubMed:18772128, PubMed:18094042). In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation (PubMed:32253259). {ECO:0000269|PubMed:18094042, ECO:0000269|PubMed:18772128, ECO:0000269|PubMed:32253259}.		layer formation in cerebral cortex [GO:0021819]; lipid modification [GO:0030258]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phosphatidylinositol biosynthetic process [GO:0006661]; regulation of triglyceride metabolic process [GO:0090207]; ventricular system development [GO:0021591]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; lysophospholipid acyltransferase activity [GO:0071617]; O-acyltransferase activity [GO:0008374]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; lysophospholipid acyltransferase activity [GO:0071617]; O-acyltransferase activity [GO:0008374]; layer formation in cerebral cortex [GO:0021819]; lipid modification [GO:0030258]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phosphatidylinositol biosynthetic process [GO:0006661]; regulation of triglyceride metabolic process [GO:0090207]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23510452, ECO:0000269|PubMed:30959108}; Multi-pass membrane protein {ECO:0000305|PubMed:30959108}. Note=Localized in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. {ECO:0000269|PubMed:23510452}.
Q96N67	reviewed	DOCK7_HUMAN	Dedicator of cytokinesis protein 7	DOCK7 KIAA1771	Homo sapiens (Human)	2140	FUNCTION: Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}.		activation of GTPase activity [GO:0090630]; axonogenesis [GO:0007409]; establishment of neuroblast polarity [GO:0045200]; interkinetic nuclear migration [GO:0022027]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of cold-induced thermogenesis [GO:0120163]; neuron projection development [GO:0031175]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; regulation of neurogenesis [GO:0050767]; small GTPase mediated signal transduction [GO:0007264]	axon [GO:0030424]; basal part of cell [GO:0045178]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; neuron projection [GO:0043005]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	axon [GO:0030424]; basal part of cell [GO:0045178]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; neuron projection [GO:0043005]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; activation of GTPase activity [GO:0090630]; axonogenesis [GO:0007409]; establishment of neuroblast polarity [GO:0045200]; interkinetic nuclear migration [GO:0022027]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of cold-induced thermogenesis [GO:0120163]; neuron projection development [GO:0031175]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; regulation of neurogenesis [GO:0050767]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000269|PubMed:16982419}. Note=Enriched in the developing axons of hippocampal neurons.
Q96N76	reviewed	HUTU_HUMAN	Urocanate hydratase (Urocanase) (EC 4.2.1.49) (Imidazolonepropionate hydrolase)	UROC1	Homo sapiens (Human)	676			histidine catabolic process [GO:0006548]; histidine catabolic process to glutamate and formamide [GO:0019556]; histidine catabolic process to glutamate and formate [GO:0019557]	cytosol [GO:0005829]	urocanate hydratase activity [GO:0016153]	cytosol [GO:0005829]; urocanate hydratase activity [GO:0016153]; histidine catabolic process [GO:0006548]; histidine catabolic process to glutamate and formamide [GO:0019556]; histidine catabolic process to glutamate and formate [GO:0019557]	
Q96N77	reviewed	ZN641_HUMAN	Zinc finger protein 641	ZNF641	Homo sapiens (Human)	438	FUNCTION: Transcriptional activator. Activates transcriptional activities of SRE and AP-1. {ECO:0000269|PubMed:16343441}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16343441}.
Q96N87	reviewed	S6A18_HUMAN	Inactive sodium-dependent neutral amino acid transporter B(0)AT3 (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3)	SLC6A18 B0AT3 XTRP2	Homo sapiens (Human)	628	FUNCTION: Does not show neutral amino acid transporter activity. {ECO:0000269|PubMed:26240152}.		amino acid transport [GO:0006865]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; renal amino acid absorption [GO:1990297]; sodium ion transmembrane transport [GO:0035725]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; neutral L-amino acid:sodium:chloride symporter activity [GO:0140931]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; neutral L-amino acid:sodium:chloride symporter activity [GO:0140931]; amino acid transport [GO:0006865]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; renal amino acid absorption [GO:1990297]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q96N95	reviewed	ZN396_HUMAN	Zinc finger protein 396 (Zinc finger and SCAN domain-containing protein 14)	ZNF396 ZSCAN14	Homo sapiens (Human)	335	FUNCTION: Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors. {ECO:0000269|PubMed:12801647}.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm.
Q96N96	reviewed	SPT13_HUMAN	Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2)	SPATA13	Homo sapiens (Human)	652	FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}.		cell migration [GO:0016477]; filopodium assembly [GO:0046847]; lamellipodium assembly [GO:0030032]; regulation of cell migration [GO:0030334]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; ruffle membrane [GO:0032587]	guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; ruffle membrane [GO:0032587]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; cell migration [GO:0016477]; filopodium assembly [GO:0046847]; lamellipodium assembly [GO:0030032]; regulation of cell migration [GO:0030334]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.
Q96NA2	reviewed	RILP_HUMAN	Rab-interacting lysosomal protein	RILP PP10141	Homo sapiens (Human)	401	FUNCTION: Rab effector playing a role in late endocytic transport to degradative compartments (PubMed:11696325, PubMed:14668488, PubMed:27113757, PubMed:11179213, PubMed:12944476). Involved in the regulation of lysosomal morphology and distribution (PubMed:14668488, PubMed:27113757). Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments (PubMed:11179213, PubMed:11696325). Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes (PubMed:12944476). {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:11696325, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14668488, ECO:0000269|PubMed:27113757}.		cilium assembly [GO:0060271]; early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; endosome transport via multivesicular body sorting pathway [GO:0032509]; intralumenal vesicle formation [GO:0070676]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of protein catabolic process [GO:0045732]; protein transport [GO:0015031]; regulation of multivesicular body size [GO:0010796]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; phagocytic vesicle membrane [GO:0030670]; protein-containing complex [GO:0032991]	dynein light intermediate chain binding [GO:0051959]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; phagocytic vesicle membrane [GO:0030670]; protein-containing complex [GO:0032991]; dynein light intermediate chain binding [GO:0051959]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267]; cilium assembly [GO:0060271]; early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; endosome transport via multivesicular body sorting pathway [GO:0032509]; intralumenal vesicle formation [GO:0070676]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of protein catabolic process [GO:0045732]; protein transport [GO:0015031]; regulation of multivesicular body size [GO:0010796]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476}. Lysosome membrane {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14668488}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:12944476}. Note=Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes. {ECO:0000269|PubMed:12944476}.
Q96NB1	reviewed	CEP20_HUMAN	Centrosomal protein 20 (FGFR1OP N-terminal-like protein) (FOP-related protein of 20 kDa) (LisH domain-containing protein FOPNL)	CEP20 C16orf63 FOPNL FOR20 PHSECRG2	Homo sapiens (Human)	174	FUNCTION: Involved in the biogenesis of cilia (PubMed:20551181). Required for the recruitment of PLK1 to centrosomes and S phase progression (PubMed:24018379). {ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24018379}.		cilium assembly [GO:0060271]; microtubule anchoring [GO:0034453]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; cilium assembly [GO:0060271]; microtubule anchoring [GO:0034453]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26643951}. Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24018379}. Cytoplasmic granule {ECO:0000269|PubMed:20551181}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:26643951}. Note=Localizes to the centrosome throughout cell cycle progression (PubMed:24018379). Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP (PubMed:26643951). {ECO:0000269|PubMed:24018379, ECO:0000269|PubMed:26643951}.
Q96NB2	reviewed	SFXN2_HUMAN	Sideroflexin-2	SFXN2	Homo sapiens (Human)	322	FUNCTION: Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria (PubMed:30442778). Involved in mitochondrial iron homeostasis by regulating heme biosynthesis (PubMed:30570704). {ECO:0000269|PubMed:30442778, ECO:0000269|PubMed:30570704}.		mitochondrial transmembrane transport [GO:1990542]; serine import into mitochondrion [GO:0140300]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	monoatomic ion transmembrane transporter activity [GO:0015075]; serine transmembrane transporter activity [GO:0022889]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; monoatomic ion transmembrane transporter activity [GO:0015075]; serine transmembrane transporter activity [GO:0022889]; mitochondrial transmembrane transport [GO:1990542]; serine import into mitochondrion [GO:0140300]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30442778}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000269|PubMed:30570704}; Multi-pass membrane protein {ECO:0000255}.
Q96NB3	reviewed	ZN830_HUMAN	Zinc finger protein 830 (Coiled-coil domain-containing protein 16)	ZNF830 CCDC16	Homo sapiens (Human)	372	FUNCTION: May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity). {ECO:0000250|UniProtKB:Q8R1N0, ECO:0000305|PubMed:25599396}.		blastocyst growth [GO:0001832]; cell division [GO:0051301]; chromosome organization [GO:0051276]; intestinal epithelial structure maintenance [GO:0060729]; mitotic DNA damage checkpoint signaling [GO:0044773]; mitotic DNA replication checkpoint signaling [GO:0033314]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; nuclear DNA replication [GO:0033260]; ovarian follicle development [GO:0001541]; preantral ovarian follicle growth [GO:0001546]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; blastocyst growth [GO:0001832]; cell division [GO:0051301]; chromosome organization [GO:0051276]; intestinal epithelial structure maintenance [GO:0060729]; mitotic DNA damage checkpoint signaling [GO:0044773]; mitotic DNA replication checkpoint signaling [GO:0033314]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; nuclear DNA replication [GO:0033260]; ovarian follicle development [GO:0001541]; preantral ovarian follicle growth [GO:0001546]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25599396}. Chromosome {ECO:0000250|UniProtKB:Q8R1N0}. Nucleus speckle {ECO:0000250|UniProtKB:Q8R1N0}. Note=Excluded from nucleolus. {ECO:0000250|UniProtKB:Q8R1N0}.
Q96NC0	reviewed	ZMAT2_HUMAN	Zinc finger matrin-type protein 2	ZMAT2	Homo sapiens (Human)	199	FUNCTION: Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:28781166}.		mRNA splicing, via spliceosome [GO:0000398]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28781166}.
Q96NE9	reviewed	FRMD6_HUMAN	FERM domain-containing protein 6 (Willin)	FRMD6 C14orf31	Homo sapiens (Human)	622			apical constriction [GO:0003383]; positive regulation of hippo signaling [GO:0035332]; protein localization [GO:0008104]; regulation of actin filament-based process [GO:0032970]	apical junction complex [GO:0043296]; cytoplasm [GO:0005737]; cytoplasmic side of apical plasma membrane [GO:0098592]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]		apical junction complex [GO:0043296]; cytoplasm [GO:0005737]; cytoplasmic side of apical plasma membrane [GO:0098592]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; apical constriction [GO:0003383]; positive regulation of hippo signaling [GO:0035332]; protein localization [GO:0008104]; regulation of actin filament-based process [GO:0032970]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16137681}. Cell membrane {ECO:0000269|PubMed:16137681}; Peripheral membrane protein {ECO:0000269|PubMed:16137681}; Cytoplasmic side {ECO:0000269|PubMed:16137681}. Note=Can colocalize with actin.
Q96NG3	reviewed	ODAD4_HUMAN	Outer dynein arm-docking complex subunit 4 (Tetratricopeptide repeat protein 25) (TPR repeat protein 25)	ODAD4 TTC25	Homo sapiens (Human)	672	FUNCTION: Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Plays an essential role for the assembly of ODA-DC and for the docking of ODA in ciliary axoneme. {ECO:0000269|PubMed:27486780}.		brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; heart development [GO:0007507]; lung development [GO:0030324]; mucociliary clearance [GO:0120197]; outer dynein arm assembly [GO:0036158]; protein localization to motile cilium [GO:0120229]	9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; outer dynein arm docking complex [GO:0120228]		9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; outer dynein arm docking complex [GO:0120228]; brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; heart development [GO:0007507]; lung development [GO:0030324]; mucociliary clearance [GO:0120197]; outer dynein arm assembly [GO:0036158]; protein localization to motile cilium [GO:0120229]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:27486780}.
Q96NG5	reviewed	ZN558_HUMAN	Zinc finger protein 558	ZNF558	Homo sapiens (Human)	402	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96NH3	reviewed	BROMI_HUMAN	Protein broad-minded (TBC1 domain family member 32)	TBC1D32 BROMI C6orf170 C6orf171	Homo sapiens (Human)	1257	FUNCTION: Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	determination of left/right symmetry [GO:0007368]; embryonic digit morphogenesis [GO:0042733]; heart development [GO:0007507]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; non-motile cilium assembly [GO:1905515]; protein localization to cilium [GO:0061512]; retinal pigment epithelium development [GO:0003406]; roof of mouth development [GO:0060021]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]	cilium [GO:0005929]; cytoplasm [GO:0005737]		cilium [GO:0005929]; cytoplasm [GO:0005737]; determination of left/right symmetry [GO:0007368]; embryonic digit morphogenesis [GO:0042733]; heart development [GO:0007507]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; non-motile cilium assembly [GO:1905515]; protein localization to cilium [GO:0061512]; retinal pigment epithelium development [GO:0003406]; roof of mouth development [GO:0060021]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
Q96NI6	reviewed	LRFN5_HUMAN	Leucine-rich repeat and fibronectin type-III domain-containing protein 5	LRFN5 C14orf146 SALM5	Homo sapiens (Human)	719	FUNCTION: Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons. {ECO:0000269|PubMed:18227064, ECO:0000269|PubMed:18585462}.		negative regulation of inflammatory response [GO:0050728]; negative regulation of macrophage activation [GO:0043031]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]	cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839]		cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839]; negative regulation of inflammatory response [GO:0050728]; negative regulation of macrophage activation [GO:0043031]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000305}.
Q96NL6	reviewed	SCLT1_HUMAN	Sodium channel and clathrin linker 1 (Sodium channel-associated protein 1)	SCLT1 SAP1	Homo sapiens (Human)	688	FUNCTION: Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity). {ECO:0000250}.		cilium assembly [GO:0060271]; clustering of voltage-gated sodium channels [GO:0045162]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; clathrin complex [GO:0071439]; cytosol [GO:0005829]	clathrin binding [GO:0030276]; sodium channel regulator activity [GO:0017080]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; clathrin complex [GO:0071439]; cytosol [GO:0005829]; clathrin binding [GO:0030276]; sodium channel regulator activity [GO:0017080]; cilium assembly [GO:0060271]; clustering of voltage-gated sodium channels [GO:0045162]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23348840}. Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane.
Q96NL8	reviewed	CF418_HUMAN	Cilia- and flagella-associated protein 418	CFAP418 C8orf37 smalltalk	Homo sapiens (Human)	207	FUNCTION: May be involved in photoreceptor outer segment disk morphogenesis (By similarity). {ECO:0000250|UniProtKB:Q3UJP5}.		photoreceptor cell morphogenesis [GO:0008594]	cell junction [GO:0030054]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]		cell junction [GO:0030054]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; photoreceptor cell morphogenesis [GO:0008594]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3UJP5}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q3UJP5}. Note=In the retina, located at the base of the primary cilium (PubMed:22177090). Expressed throughout photoreceptors cell body including the basal body, inner segment and synaptic terminus, but not in the outer segment. {ECO:0000250|UniProtKB:Q3UJP5, ECO:0000269|PubMed:22177090}.
Q96NM4	reviewed	TOX2_HUMAN	TOX high mobility group box family member 2 (Granulosa cell HMG box protein 1) (GCX-1)	TOX2 C20orf100 GCX1	Homo sapiens (Human)	488	FUNCTION: Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; transcription coactivator activity [GO:0003713]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; transcription coactivator activity [GO:0003713]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Q96NN9	reviewed	AIFM3_HUMAN	Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor-like protein)	AIFM3 AIFL	Homo sapiens (Human)	605	FUNCTION: Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. {ECO:0000269|PubMed:15764604}.		execution phase of apoptosis [GO:0097194]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	2 iron, 2 sulfur cluster binding [GO:0051537]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]; execution phase of apoptosis [GO:0097194]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15764604}. Note=Does not translocate to the nucleus upon induction of apoptosis.
Q96NR3	reviewed	PTHD1_HUMAN	Patched domain-containing protein 1	PTCHD1	Homo sapiens (Human)	888	FUNCTION: Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, generation of sleep rhythms, sensorimotor processing and attention. {ECO:0000250|UniProtKB:Q14B62}.		chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; excitatory chemical synaptic transmission [GO:0098976]; inhibitory chemical synaptic transmission [GO:0098977]; long-term memory [GO:0007616]; short-term memory [GO:0007614]; smoothened signaling pathway [GO:0007224]; social behavior [GO:0035176]; thalamus development [GO:0021794]	plasma membrane [GO:0005886]; synapse [GO:0045202]		plasma membrane [GO:0005886]; synapse [GO:0045202]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; excitatory chemical synaptic transmission [GO:0098976]; inhibitory chemical synaptic transmission [GO:0098977]; long-term memory [GO:0007616]; short-term memory [GO:0007614]; smoothened signaling pathway [GO:0007224]; social behavior [GO:0035176]; thalamus development [GO:0021794]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20844286}; Multi-pass membrane protein {ECO:0000269|PubMed:20844286}.
Q96NR8	reviewed	RDH12_HUMAN	Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2)	RDH12 SDR7C2	Homo sapiens (Human)	316	FUNCTION: Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:15865448, PubMed:12226107). Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (PubMed:19686838, PubMed:15865448). May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). Has no dehydrogenase activity towards steroids (PubMed:15865448, PubMed:12226107). {ECO:0000269|PubMed:12226107, ECO:0000269|PubMed:15865448, ECO:0000269|PubMed:19686838}.	MISCELLANEOUS: Shows clear specificity for the pro-S hydrogen on C4 of NADPH and the pro-R hydrogen on C15 of retinols. {ECO:0000269|PubMed:12226107}.	cellular detoxification of aldehyde [GO:0110095]; photoreceptor cell maintenance [GO:0045494]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]	endoplasmic reticulum membrane [GO:0005789]; photoreceptor inner segment [GO:0001917]; photoreceptor inner segment membrane [GO:0060342]	11-cis-retinol dehydrogenase activity [GO:0102354]; NAD-retinol dehydrogenase activity [GO:0004745]; NADP-retinol dehydrogenase activity [GO:0052650]	endoplasmic reticulum membrane [GO:0005789]; photoreceptor inner segment [GO:0001917]; photoreceptor inner segment membrane [GO:0060342]; 11-cis-retinol dehydrogenase activity [GO:0102354]; NAD-retinol dehydrogenase activity [GO:0004745]; NADP-retinol dehydrogenase activity [GO:0052650]; cellular detoxification of aldehyde [GO:0110095]; photoreceptor cell maintenance [GO:0045494]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15865448}.
Q96NT0	reviewed	CC115_HUMAN	Coiled-coil domain-containing protein 115	CCDC115	Homo sapiens (Human)	180	FUNCTION: Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833332). {ECO:0000269|PubMed:26833332, ECO:0000269|PubMed:28296633}.		cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	COPI-coated vesicle [GO:0030137]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]	unfolded protein binding [GO:0051082]	COPI-coated vesicle [GO:0030137]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; unfolded protein binding [GO:0051082]; cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:Q8VE99}. Lysosome {ECO:0000250|UniProtKB:Q8VE99}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:26833332}. Cytoplasmic vesicle, COPI-coated vesicle {ECO:0000269|PubMed:26833332}. Endoplasmic reticulum {ECO:0000269|PubMed:28296633}.
Q96NT3	reviewed	GUCD1_HUMAN	Protein GUCD1 (Guanylyl cyclase domain-containing protein 1) (Protein LLN4)	GUCD1 C22orf13 LLN4	Homo sapiens (Human)	240			liver regeneration [GO:0097421]; response to cAMP [GO:0051591]			liver regeneration [GO:0097421]; response to cAMP [GO:0051591]	
Q96NT5	reviewed	PCFT_HUMAN	Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)	SLC46A1 G21 HCP1 PCFT	Homo sapiens (Human)	459	FUNCTION: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:17129779, PubMed:17446347, PubMed:17475902, PubMed:19389703, PubMed:19762432, PubMed:25504888, PubMed:30858177, PubMed:31792273, PubMed:34619546, PubMed:29344585, PubMed:31494288, PubMed:32893190). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:17129779, PubMed:17446347, PubMed:17475902, PubMed:19389703, PubMed:25504888, PubMed:30858177, PubMed:29344585, PubMed:31494288, PubMed:32893190). Functions at acidic pH via alternate outward- and inward-open conformation states (PubMed:34040256, PubMed:32893190). Protonation of residues in the outward open state primes the protein for transport (PubMed:34040256). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (PubMed:34040256). Also able to transport antifolate drugs, such as methotrexate and pemetrexed, which are established treatments for cancer and autoimmune diseases (PubMed:18524888, PubMed:19762432, PubMed:25608532, PubMed:28802835, PubMed:29326243, PubMed:34619546, PubMed:34040256, PubMed:22345511). Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (PubMed:19074442). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (PubMed:17156779). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (PubMed:32621820). Hence, participates in the trafficking of heme and increases intracellular iron content (PubMed:32621820). {ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17156779, ECO:0000269|PubMed:17446347, ECO:0000269|PubMed:17475902, ECO:0000269|PubMed:18524888, ECO:0000269|PubMed:19074442, ECO:0000269|PubMed:19389703, ECO:0000269|PubMed:19762432, ECO:0000269|PubMed:22345511, ECO:0000269|PubMed:25504888, ECO:0000269|PubMed:25608532, ECO:0000269|PubMed:28802835, ECO:0000269|PubMed:29326243, ECO:0000269|PubMed:29344585, ECO:0000269|PubMed:30858177, ECO:0000269|PubMed:31494288, ECO:0000269|PubMed:31792273, ECO:0000269|PubMed:32621820, ECO:0000269|PubMed:32893190, ECO:0000269|PubMed:34040256, ECO:0000269|PubMed:34619546}.; FUNCTION: [Isoform 2]: Inactive isoform which is not able to mediate proton-coupled folate transport. {ECO:0000269|PubMed:17129779}.	MISCELLANEOUS: Constitutes an important route for the delivery of antifolate drugs, such as methotrexate and pemetrexed, in cancer chemotherapy (PubMed:18524888, PubMed:34040256). Ubiquitously expressed in solid tumors to which it delivers antifolates: within the acid microenvironment of cancer cells, antifolate drugs uptake mediated by SLC46A1/PCFT is increased (PubMed:18524888, PubMed:34040256). {ECO:0000269|PubMed:18524888, ECO:0000269|PubMed:34040256}.	folate import across plasma membrane [GO:1904447]; folate transmembrane transport [GO:0098838]; folic acid metabolic process [GO:0046655]; folic acid transport [GO:0015884]; heme metabolic process [GO:0042168]; intestinal folate absorption [GO:0098829]; intracellular iron ion homeostasis [GO:0006879]; proton transmembrane transport [GO:1902600]; transmembrane transport [GO:0055085]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	folic acid binding [GO:0005542]; folic acid transmembrane transporter activity [GO:0008517]; folic acid:proton symporter activity [GO:0140211]; heme transmembrane transporter activity [GO:0015232]; methotrexate transmembrane transporter activity [GO:0015350]; proton transmembrane transporter activity [GO:0015078]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; folic acid binding [GO:0005542]; folic acid transmembrane transporter activity [GO:0008517]; folic acid:proton symporter activity [GO:0140211]; heme transmembrane transporter activity [GO:0015232]; methotrexate transmembrane transporter activity [GO:0015350]; proton transmembrane transporter activity [GO:0015078]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]; folate import across plasma membrane [GO:1904447]; folate transmembrane transport [GO:0098838]; folic acid metabolic process [GO:0046655]; folic acid transport [GO:0015884]; heme metabolic process [GO:0042168]; intestinal folate absorption [GO:0098829]; intracellular iron ion homeostasis [GO:0006879]; proton transmembrane transport [GO:1902600]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17156779, ECO:0000269|PubMed:17446347, ECO:0000269|PubMed:18405659, ECO:0000269|PubMed:23601781, ECO:0000269|PubMed:25053408, ECO:0000269|PubMed:25504888, ECO:0000269|PubMed:29344585, ECO:0000269|PubMed:30858177, ECO:0000269|PubMed:34619546}; Multi-pass membrane protein {ECO:0000269|PubMed:25053408}. Apical cell membrane {ECO:0000269|PubMed:16143108, ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17475902}; Multi-pass membrane protein {ECO:0000269|PubMed:25053408}. Basolateral cell membrane {ECO:0000269|PubMed:19074442}; Multi-pass membrane protein {ECO:0000269|PubMed:25053408}. Endosome membrane {ECO:0000305|PubMed:19074442}; Multi-pass membrane protein {ECO:0000269|PubMed:25053408}. Cytoplasm {ECO:0000250|UniProtKB:Q6PEM8}. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells (By similarity). Localizes to the basolateral membrane of choroid plexus (PubMed:19074442). {ECO:0000250|UniProtKB:Q6PEM8, ECO:0000269|PubMed:19074442}.
Q96NU1	reviewed	SAM11_HUMAN	Sterile alpha motif domain-containing protein 11 (SAM domain-containing protein 11)	SAMD11	Homo sapiens (Human)	681	FUNCTION: May play a role in photoreceptor development. {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage and alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative splicing. {ECO:0000305}.	negative regulation of DNA-templated transcription [GO:0045892]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96NW4	reviewed	ANR27_HUMAN	Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein)	ANKRD27 PP12899	Homo sapiens (Human)	1050	FUNCTION: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:Q3UMR0, ECO:0000269|PubMed:23104059, ECO:0000269|PubMed:24856514, ECO:0000305|PubMed:16525121, ECO:0000305|PubMed:18477474, ECO:0000305|PubMed:22705394}.		early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; endosome to melanosome transport [GO:0035646]; negative regulation of SNARE complex assembly [GO:0035544]; neuron projection morphogenesis [GO:0048812]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of neuron projection development [GO:0010976]; protein transport [GO:0015031]	cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; tubular endosome [GO:0097422]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]	cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; tubular endosome [GO:0097422]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; endosome to melanosome transport [GO:0035646]; negative regulation of SNARE complex assembly [GO:0035544]; neuron projection morphogenesis [GO:0048812]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of neuron projection development [GO:0010976]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:16525121, ECO:0000269|PubMed:24856514}. Late endosome {ECO:0000269|PubMed:23104059}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:23104059}. Lysosome {ECO:0000269|PubMed:23104059}. Cell membrane {ECO:0000269|PubMed:23104059}. Melanosome {ECO:0000250|UniProtKB:Q3UMR0}. Note=Colocalizes with VAMP7 in transport vesicles in the shaft of hippocampal neurons (By similarity). {ECO:0000250|UniProtKB:Q3UMR0}.
Q96NW7	reviewed	LRRC7_HUMAN	Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1)	LRRC7 KIAA1365 LAP1	Homo sapiens (Human)	1537	FUNCTION: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. {ECO:0000269|PubMed:11729199}.		cell-cell adhesion [GO:0098609]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of neuron projection development [GO:0010976]; receptor clustering [GO:0043113]	adherens junction [GO:0005912]; axon initial segment [GO:0043194]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular region [GO:0005576]; postsynaptic density [GO:0014069]; specific granule lumen [GO:0035580]		adherens junction [GO:0005912]; axon initial segment [GO:0043194]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular region [GO:0005576]; postsynaptic density [GO:0014069]; specific granule lumen [GO:0035580]; cell-cell adhesion [GO:0098609]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of neuron projection development [GO:0010976]; receptor clustering [GO:0043113]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11729199}. Postsynaptic density {ECO:0000250}.
Q96NX5	reviewed	KCC1G_HUMAN	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase I gamma) (CaM kinase IG) (CaM-KI gamma) (CaMKI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III)	CAMK1G CLICK3 VWS1	Homo sapiens (Human)	476	FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity). {ECO:0000250}.		phosphorylation [GO:0016310]	calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]	calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q96NY7	reviewed	CLIC6_HUMAN	Chloride intracellular channel protein 6 (Parchorin)	CLIC6 CLIC1L	Homo sapiens (Human)	704	FUNCTION: May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO:0000250}.		regulation of monoatomic ion transmembrane transport [GO:0034765]	chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]; D2 dopamine receptor binding [GO:0031749]; D3 dopamine receptor binding [GO:0031750]; D4 dopamine receptor binding [GO:0031751]; voltage-gated monoatomic ion channel activity [GO:0005244]	chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; D2 dopamine receptor binding [GO:0031749]; D3 dopamine receptor binding [GO:0031750]; D4 dopamine receptor binding [GO:0031751]; voltage-gated monoatomic ion channel activity [GO:0005244]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). {ECO:0000250}.
Q96NY8	reviewed	NECT4_HUMAN	Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4]	NECTIN4 LNIR PRR4 PVRL4	Homo sapiens (Human)	510	FUNCTION: Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.; FUNCTION: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:22048310, ECO:0000269|PubMed:23202587}.		heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	adherens junction [GO:0005912]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; virus receptor activity [GO:0001618]	adherens junction [GO:0005912]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; virus receptor activity [GO:0001618]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:11544254}. Note=Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).; SUBCELLULAR LOCATION: [Processed poliovirus receptor-related protein 4]: Secreted {ECO:0000269|PubMed:15784625}. Note=The secreted form is found in breast tumor patients (PubMed:15784625).
Q96NY9	reviewed	MUS81_HUMAN	Crossover junction endonuclease MUS81 (EC 3.1.22.-)	MUS81	Homo sapiens (Human)	551	FUNCTION: Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. Plays an essential role in mitosis for the processing of stalled or collapsed replication forks (PubMed:28575661). {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:12374758, ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:15805243, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:28575661}.		DNA catabolic process [GO:0006308]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via break-induced replication [GO:0000727]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; osteoblast proliferation [GO:0033687]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]; response to intra-S DNA damage checkpoint signaling [GO:0072429]	endodeoxyribonuclease complex [GO:1905347]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]	3'-flap endonuclease activity [GO:0048257]; crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]	endodeoxyribonuclease complex [GO:1905347]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; 3'-flap endonuclease activity [GO:0048257]; crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; DNA catabolic process [GO:0006308]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via break-induced replication [GO:0000727]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; osteoblast proliferation [GO:0033687]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]; response to intra-S DNA damage checkpoint signaling [GO:0072429]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:14638871, ECO:0000269|PubMed:15805243}. Note=Recruited to foci of DNA damage in S-phase cells.
Q96NZ1	reviewed	FOXN4_HUMAN	Forkhead box protein N4	FOXN4	Homo sapiens (Human)	517	FUNCTION: Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity). {ECO:0000250}.		amacrine cell differentiation [GO:0035881]; atrioventricular canal development [GO:0036302]; heart looping [GO:0001947]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of heart contraction [GO:0008016]; retina layer formation [GO:0010842]; ventral spinal cord interneuron differentiation [GO:0021514]; ventral spinal cord interneuron fate commitment [GO:0060579]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; amacrine cell differentiation [GO:0035881]; atrioventricular canal development [GO:0036302]; heart looping [GO:0001947]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of heart contraction [GO:0008016]; retina layer formation [GO:0010842]; ventral spinal cord interneuron differentiation [GO:0021514]; ventral spinal cord interneuron fate commitment [GO:0060579]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Q96NZ8	reviewed	WFKN1_HUMAN	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 (Growth and differentiation factor-associated serum protein 2) (GASP-2) (hGASP-2) (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein)	WFIKKN1 C16orf12 GASP2 WFIKKN PSEC0040	Homo sapiens (Human)	548	FUNCTION: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity). {ECO:0000250}.		muscle cell development [GO:0055001]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]; transforming growth factor beta receptor signaling pathway [GO:0007179]	extracellular space [GO:0005615]	metalloendopeptidase inhibitor activity [GO:0008191]; receptor antagonist activity [GO:0048019]; serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431]	extracellular space [GO:0005615]; metalloendopeptidase inhibitor activity [GO:0008191]; receptor antagonist activity [GO:0048019]; serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431]; muscle cell development [GO:0055001]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q96NZ9	reviewed	PRAP1_HUMAN	Proline-rich acidic protein 1 (Epididymis tissue protein Li 178) (Uterine-specific proline-rich acidic protein)	PRAP1 UPA UNQ608/PRO1195	Homo sapiens (Human)	151	FUNCTION: Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity). May play an important role in maintaining normal growth homeostasis in epithelial cells (PubMed:14583459). Involved in p53/TP53-dependent cell survival after DNA damage (PubMed:23235459). May down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas (PubMed:24374861). {ECO:0000250|UniProtKB:Q80XD8, ECO:0000269|PubMed:14583459, ECO:0000269|PubMed:23235459, ECO:0000269|PubMed:24374861}.		cellular response to X-ray [GO:0071481]; deactivation of mitotic spindle assembly checkpoint [GO:1902426]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; negative regulation of apoptotic process [GO:0043066]; positive regulation of intestinal lipid absorption [GO:1904731]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of triglyceride transport [GO:1905885]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]	triglyceride binding [GO:0017129]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; triglyceride binding [GO:0017129]; cellular response to X-ray [GO:0071481]; deactivation of mitotic spindle assembly checkpoint [GO:1902426]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; negative regulation of apoptotic process [GO:0043066]; positive regulation of intestinal lipid absorption [GO:1904731]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of triglyceride transport [GO:1905885]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14583459}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q80XD8}.
Q96P09	reviewed	BIRC8_HUMAN	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis)	BIRC8 ILP2	Homo sapiens (Human)	236	FUNCTION: Protects against apoptosis mediated by BAX.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein ubiquitination [GO:0031398]; regulation of cell cycle [GO:0051726]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein ubiquitination [GO:0031398]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q96P11	reviewed	NSUN5_HUMAN	28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein)	NSUN5 NSUN5A WBSCR20 WBSCR20A	Homo sapiens (Human)	429	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity). {ECO:0000250|UniProtKB:Q8K4F6, ECO:0000269|PubMed:23913415, ECO:0000269|PubMed:31428936, ECO:0000269|PubMed:31722427}.		cerebral cortex development [GO:0021987]; cognition [GO:0050890]; corpus callosum development [GO:0022038]; oligodendrocyte development [GO:0014003]; positive regulation of translation [GO:0045727]; regulation of myelination [GO:0031641]; rRNA base methylation [GO:0070475]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383]; cerebral cortex development [GO:0021987]; cognition [GO:0050890]; corpus callosum development [GO:0022038]; oligodendrocyte development [GO:0014003]; positive regulation of translation [GO:0045727]; regulation of myelination [GO:0031641]; rRNA base methylation [GO:0070475]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:31722427}.
Q96P16	reviewed	RPR1A_HUMAN	Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein)	RPRD1A P15RS	Homo sapiens (Human)	312	FUNCTION: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.		mRNA 3'-end processing [GO:0031124]; RNA polymerase II promoter clearance [GO:0001111]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550]	identical protein binding [GO:0042802]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550]; identical protein binding [GO:0042802]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993]; mRNA 3'-end processing [GO:0031124]; RNA polymerase II promoter clearance [GO:0001111]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22231121}.
Q96P20	reviewed	NLRP3_HUMAN	NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)	NLRP3 C1orf7 CIAS1 NALP3 PYPAF1	Homo sapiens (Human)	1036	FUNCTION: Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18604214, PubMed:18403674, PubMed:23582325, PubMed:28847925, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:27929086, PubMed:28656979, PubMed:25686105, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:28847925, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:27432880, PubMed:31189953, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:31189953). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18604214, PubMed:18403674, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:16407889, ECO:0000269|PubMed:17483456, ECO:0000269|PubMed:18403674, ECO:0000269|PubMed:18604214, ECO:0000269|PubMed:19414800, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25686105, ECO:0000269|PubMed:27432880, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:28656979, ECO:0000269|PubMed:28847925, ECO:0000269|PubMed:30487600, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:31086327, ECO:0000269|PubMed:31086329, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:33231615, ECO:0000269|PubMed:34133077, ECO:0000269|PubMed:34341353, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:35114687, ECO:0000269|PubMed:36142182, ECO:0000269|PubMed:36442502}.; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8}.		apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; defense response [GO:0006952]; detection of biotic stimulus [GO:0009595]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; NLRP3 inflammasome complex assembly [GO:0044546]; osmosensory signaling pathway [GO:0007231]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type 2 immune response [GO:0002830]; protein homooligomerization [GO:0051260]; protein maturation [GO:0051604]; pyroptosis [GO:0070269]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; interphase microtubule organizing center [GO:0031021]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; NLRP3 inflammasome complex [GO:0072559]; nucleus [GO:0005634]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase activator activity [GO:0140608]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; peptidoglycan binding [GO:0042834]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-4-phosphate binding [GO:0070273]; sequence-specific DNA binding [GO:0043565]; signaling adaptor activity [GO:0035591]; small molecule sensor activity [GO:0140299]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; interphase microtubule organizing center [GO:0031021]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; NLRP3 inflammasome complex [GO:0072559]; nucleus [GO:0005634]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase activator activity [GO:0140608]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; peptidoglycan binding [GO:0042834]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-4-phosphate binding [GO:0070273]; sequence-specific DNA binding [GO:0043565]; signaling adaptor activity [GO:0035591]; small molecule sensor activity [GO:0140299]; apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; defense response [GO:0006952]; detection of biotic stimulus [GO:0009595]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; NLRP3 inflammasome complex assembly [GO:0044546]; osmosensory signaling pathway [GO:0007231]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type 2 immune response [GO:0002830]; protein homooligomerization [GO:0051260]; protein maturation [GO:0051604]; pyroptosis [GO:0070269]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11786556, ECO:0000269|PubMed:14662828, ECO:0000269|PubMed:17164409}. Inflammasome {ECO:0000269|PubMed:11786556, ECO:0000269|PubMed:14662828, ECO:0000269|PubMed:17164409, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25538194, ECO:0000269|PubMed:33231615}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:28656979}. Golgi apparatus membrane {ECO:0000269|PubMed:23229815, ECO:0000269|PubMed:30487600}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8R4B8}. Mitochondrion {ECO:0000269|PubMed:21124315, ECO:0000269|PubMed:23582325}. Secreted {ECO:0000269|PubMed:24952504}. Nucleus {ECO:0000250|UniProtKB:Q8R4B8}. Note=In macrophages, under resting conditions, mainly located in the cytosol and on membranes of various organelles, such as endoplasmic reticulum, mitochondria and Golgi: forms an inactive double-ring cage that is primarily localized on membranes (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes for the formation of an active inflammasome complex (By similarity). Recruited to dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600). After the induction of pyroptosis, inflammasome specks are released into the extracellular space where they can further promote IL1B processing and where they can be engulfed by macrophages (PubMed:24952504). Phagocytosis induces lysosomal damage and inflammasome activation in the recipient cells (PubMed:24952504). In the Th2 subset of CD4(+) helper T-cells, mainly located in the nucleus (By similarity). Nuclear localization depends upon KPNA2 (By similarity). In the Th1 subset of CD4(+) helper T-cells, mainly cytoplasmic (By similarity). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:24952504, ECO:0000269|PubMed:30487600}.
Q96P26	reviewed	5NT1B_HUMAN	Cytosolic 5'-nucleotidase 1B (cN1B) (EC 3.1.3.5) (Autoimmune infertility-related protein) (Cytosolic 5'-nucleotidase IB) (cN-IB)	NT5C1B AIRP FKSG85	Homo sapiens (Human)	610	FUNCTION: Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, AMP is the major substrate. {ECO:0000250|UniProtKB:Q91YE9}.		adenosine metabolic process [GO:0046085]; purine nucleotide catabolic process [GO:0006195]	cytosol [GO:0005829]; nucleus [GO:0005634]	5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; XMP 5'-nucleosidase activity [GO:0106411]	cytosol [GO:0005829]; nucleus [GO:0005634]; 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; XMP 5'-nucleosidase activity [GO:0106411]; adenosine metabolic process [GO:0046085]; purine nucleotide catabolic process [GO:0006195]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BXI3}.
Q96P31	reviewed	FCRL3_HUMAN	Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (MAIA) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c)	FCRL3 FCRH3 IFGP3 IRTA3 SPAP2	Homo sapiens (Human)	734	FUNCTION: Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275). Acts as a human-specific epitope on the cell surface of oocytes (oolemma) and plays a role during sperm-egg adhesion and fusion (PubMed:36070373). Interacts with the IZUMO1-IZUMO1R/JUNO sperm-egg complex and replaces IZUMO1R/JUNO as IZUMO1 receptor during fertilization, thereby permitting species-specific gamete fusion (PubMed:36070373). {ECO:0000269|PubMed:19494275, ECO:0000269|PubMed:19843936, ECO:0000269|PubMed:20190142, ECO:0000269|PubMed:23857366, ECO:0000269|PubMed:36070373}.		cell surface receptor signaling pathway [GO:0007166]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of immunoglobulin production [GO:0002638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein serine/threonine phosphatase activity [GO:1905184]; regulation of B cell activation [GO:0050864]; regulation of B cell differentiation [GO:0045577]; regulation of calcium ion import [GO:0090279]; regulation of toll-like receptor 9 signaling pathway [GO:0034163]; single fertilization [GO:0007338]	cell surface [GO:0009986]; microvillus membrane [GO:0031528]	kinase binding [GO:0019900]; phosphatase binding [GO:0019902]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; microvillus membrane [GO:0031528]; kinase binding [GO:0019900]; phosphatase binding [GO:0019902]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of immunoglobulin production [GO:0002638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein serine/threonine phosphatase activity [GO:1905184]; regulation of B cell activation [GO:0050864]; regulation of B cell differentiation [GO:0045577]; regulation of calcium ion import [GO:0090279]; regulation of toll-like receptor 9 signaling pathway [GO:0034163]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16849395, ECO:0000269|PubMed:20190142, ECO:0000269|PubMed:36070373}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}. Cell projection, microvillus membrane {ECO:0000269|PubMed:36070373}. Note=Localized along the oolemma microvilli of unfertilized oocytes. {ECO:0000269|PubMed:36070373}.
Q96P44	reviewed	COLA1_HUMAN	Collagen alpha-1(XXI) chain	COL21A1 COL1AL FP633	Homo sapiens (Human)	957				collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]		collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11863369}. Cytoplasm {ECO:0000269|PubMed:11863369}. Note=Found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle.
Q96P47	reviewed	AGAP3_HUMAN	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1)	AGAP3 CENTG3	Homo sapiens (Human)	875	FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:16461359, ECO:0000305}.		cellular response to reactive oxygen species [GO:0034614]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cell periphery [GO:0071944]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]	cell periphery [GO:0071944]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; cellular response to reactive oxygen species [GO:0034614]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16461359}. Note=In cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies.
Q96P48	reviewed	ARAP1_HUMAN	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)	ARAP1 CENTD2 KIAA0782	Homo sapiens (Human)	1450	FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11804590}.		actin filament organization [GO:0007015]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of receptor recycling [GO:0001921]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; type 1 angiotensin receptor binding [GO:0031702]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; type 1 angiotensin receptor binding [GO:0031702]; actin filament organization [GO:0007015]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of receptor recycling [GO:0001921]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.
Q96P53	reviewed	WDFY2_HUMAN	WD repeat and FYVE domain-containing protein 2 (Propeller-FYVE protein) (Prof) (WD40- and FYVE domain-containing protein 2) (Zinc finger FYVE domain-containing protein 22)	WDFY2 WDF2 ZFYVE22	Homo sapiens (Human)	400	FUNCTION: Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553). {ECO:0000250|UniProtKB:Q8BUB4, ECO:0000269|PubMed:16873553, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:18388859}.		positive regulation of fat cell differentiation [GO:0045600]; positive regulation of protein phosphorylation [GO:0001934]	early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982]	metal ion binding [GO:0046872]	early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982]; metal ion binding [GO:0046872]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of protein phosphorylation [GO:0001934]	SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:16873553}. Early endosome {ECO:0000269|PubMed:16792529}. Cytoplasm {ECO:0000250|UniProtKB:Q8BUB4}. Note=Localizes to intracellular vesicles (PubMed:16792529). Colocalizes with VAMP2 and PRKCZ in intracellular vesicles (PubMed:17313651). Colocalizes with AKT2 in early endosomes (By similarity). {ECO:0000250|UniProtKB:Q8BUB4, ECO:0000269|PubMed:16792529, ECO:0000269|PubMed:17313651}.
Q96P56	reviewed	CTSR2_HUMAN	Cation channel sperm-associated protein 2 (CatSper2)	CATSPER2	Homo sapiens (Human)	530	FUNCTION: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.		fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sperm capacitation [GO:0048240]	CatSper complex [GO:0036128]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]	calcium activated cation channel activity [GO:0005227]; calcium channel activity [GO:0005262]; voltage-gated monoatomic ion channel activity [GO:0005244]	CatSper complex [GO:0036128]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; calcium activated cation channel activity [GO:0005227]; calcium channel activity [GO:0005262]; voltage-gated monoatomic ion channel activity [GO:0005244]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:A2ARP9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A2ARP9}.
Q96P63	reviewed	SPB12_HUMAN	Serpin B12	SERPINB12	Homo sapiens (Human)	405	FUNCTION: Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator (PubMed:11604408). May play a role in cell differentiation (PubMed:30045019). {ECO:0000269|PubMed:11604408, ECO:0000269|PubMed:30045019}.		hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of protein catabolic process [GO:0042177]	collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]; serine-type endopeptidase inhibitor activity [GO:0004867]	collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; serine-type endopeptidase inhibitor activity [GO:0004867]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of protein catabolic process [GO:0042177]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96P65	reviewed	QRFPR_HUMAN	Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)	QRFPR GPR103	Homo sapiens (Human)	431	FUNCTION: Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels. {ECO:0000269|PubMed:12960173}.		cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; peptide binding [GO:0042277]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; peptide binding [GO:0042277]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96P66	reviewed	GP101_HUMAN	Probable G-protein coupled receptor 101	GPR101	Homo sapiens (Human)	508	FUNCTION: Orphan receptor.		adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96P70	reviewed	IPO9_HUMAN	Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9)	IPO9 IMP9 KIAA1192 RANBP9 HSPC273	Homo sapiens (Human)	1041	FUNCTION: Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin (PubMed:11823430, PubMed:34711951, PubMed:30855230). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex (PubMed:11823430, PubMed:34711951). Mediates the nuclear import of histones H2A, H2B, H4 and H4 (PubMed:11823430, PubMed:30855230). In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions (PubMed:30855230). Mediates the nuclear import of actin (By similarity). {ECO:0000250|UniProtKB:Q91YE6, ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:30855230, ECO:0000269|PubMed:34711951}.		proteasome localization [GO:0031144]; protein import into nucleus [GO:0006606]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]	histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267]; proteasome localization [GO:0031144]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11823430}. Nucleus {ECO:0000269|PubMed:11823430}.
Q96P71	reviewed	NECA3_HUMAN	N-terminal EF-hand calcium-binding protein 3 (Amyloid-beta A4 protein-binding family A member 2-binding protein) (Nek2-interacting protein 1) (Neuronal calcium-binding protein 3) (X11L-binding protein 51)	NECAB3 APBA2BP NIP1 SYTIP2 XB51	Homo sapiens (Human)	396	FUNCTION: Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3. {ECO:0000269|PubMed:10833507, ECO:0000269|PubMed:26948053}.	MISCELLANEOUS: [Isoform 3]: May result from the retention of an intron in the cDNA. {ECO:0000305}.	protein metabolic process [GO:0019538]; protein secretion [GO:0009306]; regulation of amyloid precursor protein biosynthetic process [GO:0042984]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; protein metabolic process [GO:0019538]; protein secretion [GO:0009306]; regulation of amyloid precursor protein biosynthetic process [GO:0042984]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:10833507, ECO:0000269|PubMed:14697346, ECO:0000269|PubMed:26948053}.
Q96PB1	reviewed	CASD1_HUMAN	N-acetylneuraminate 9-O-acetyltransferase (EC 2.3.1.45) (CAS1 domain-containing protein 1) (Sialate O-acetyltransferase) (SOAT)	CASD1 C7orf12 Nbla04196	Homo sapiens (Human)	797	FUNCTION: O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids (PubMed:20947662, PubMed:26169044). Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and are involved in various processes such as cell-cell interactions, host-pathogen recognition (PubMed:20947662, PubMed:26169044). {ECO:0000269|PubMed:26169044, ECO:0000305|PubMed:20947662}.		carbohydrate metabolic process [GO:0005975]	Golgi membrane [GO:0000139]	N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity [GO:0047186]	Golgi membrane [GO:0000139]; N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity [GO:0047186]; carbohydrate metabolic process [GO:0005975]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:26169044}; Multi-pass membrane protein {ECO:0000305}.
Q96PB7	reviewed	NOE3_HUMAN	Noelin-3 (Olfactomedin-3) (Optimedin)	OLFM3 NOE3 UNQ1924/PRO4399	Homo sapiens (Human)	478			eye photoreceptor cell development [GO:0042462]; signal transduction [GO:0007165]	AMPA glutamate receptor complex [GO:0032281]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; synapse [GO:0045202]		AMPA glutamate receptor complex [GO:0032281]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; synapse [GO:0045202]; eye photoreceptor cell development [GO:0042462]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Synapse {ECO:0000250}.
Q96PC2	reviewed	IP6K3_HUMAN	Inositol hexakisphosphate kinase 3 (InsP6 kinase 3) (EC 2.7.4.21) (Inositol hexaphosphate kinase 3)	IP6K3 IHPK3	Homo sapiens (Human)	410	FUNCTION: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. {ECO:0000269|PubMed:11502751}.		inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; locomotion [GO:0040011]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; inositol 5-diphosphate pentakisphosphate 5-kinase activity [GO:0052836]; inositol diphosphate tetrakisphosphate kinase activity [GO:0052839]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 3-kinase activity [GO:0052724]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate 6-kinase activity [GO:0000831]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; inositol 5-diphosphate pentakisphosphate 5-kinase activity [GO:0052836]; inositol diphosphate tetrakisphosphate kinase activity [GO:0052839]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 3-kinase activity [GO:0052724]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate 6-kinase activity [GO:0000831]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; locomotion [GO:0040011]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11502751}.
Q96PC3	reviewed	AP1S3_HUMAN	AP-1 complex subunit sigma-3 (Adaptor protein complex AP-1 subunit sigma-1C) (Adaptor-related protein complex 1 subunit sigma-1C) (Clathrin assembly protein complex 1 sigma-1C small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Sigma 1C subunit of AP-1 clathrin) (Sigma-adaptin 1C) (Sigma1C-adaptin)	AP1S3	Homo sapiens (Human)	154	FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904). {ECO:0000269|PubMed:24791904}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192]	AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]	clathrin adaptor activity [GO:0035615]	AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]; clathrin adaptor activity [GO:0035615]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Q96PC5	reviewed	MIA2_HUMAN	Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11)	MIA2 CTAGE5 MEA11 MEA6 MGEA11 MGEA6	Homo sapiens (Human)	1412	FUNCTION: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:27138255, PubMed:21525241, PubMed:25202031, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}.	MISCELLANEOUS: [Isoform 1]: Readthrough transcript producing a functional fusion protein MIA2-CTAGE5 with similarity to MIA3. {ECO:0000305|PubMed:21807889, ECO:0000305|PubMed:27138255}.	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; lipoprotein transport [GO:0042953]; protein exit from endoplasmic reticulum [GO:0032527]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	cargo receptor activity [GO:0038024]; enzyme activator activity [GO:0008047]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; cargo receptor activity [GO:0038024]; enzyme activator activity [GO:0008047]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; lipoprotein transport [GO:0042953]; protein exit from endoplasmic reticulum [GO:0032527]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:21807889, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:28442536}; Single-pass membrane protein {ECO:0000269|PubMed:21807889}. Note=Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). {ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:21807889, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:28442536}.
Q96PD2	reviewed	DCBD2_HUMAN	Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein)	DCBLD2 CLCP1 ESDN	Homo sapiens (Human)	775			intracellular receptor signaling pathway [GO:0030522]; negative regulation of cell growth [GO:0030308]; wound healing [GO:0042060]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; intracellular receptor signaling pathway [GO:0030522]; negative regulation of cell growth [GO:0030308]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11973641}; Single-pass type I membrane protein {ECO:0000269|PubMed:11973641}.
Q96PD4	reviewed	IL17F_HUMAN	Interleukin-17F (IL-17F) (Cytokine ML-1)	IL17F	Homo sapiens (Human)	163	FUNCTION: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:21350122). IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:18684971, PubMed:21350122, PubMed:11591732, PubMed:11591768, PubMed:17911633, PubMed:11574464, PubMed:28827714). IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation (By similarity). As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:32187518). Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes (By similarity). {ECO:0000250|UniProtKB:Q7TNI7, ECO:0000269|PubMed:11574464, ECO:0000269|PubMed:11591732, ECO:0000269|PubMed:11591768, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:28827714, ECO:0000269|PubMed:32187518}.		adaptive immune response [GO:0002250]; cartilage development [GO:0051216]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; negative regulation of angiogenesis [GO:0016525]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lymphotoxin A production [GO:0032761]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of granulocyte macrophage colony-stimulating factor production [GO:0032645]; regulation of interleukin-2 production [GO:0032663]; regulation of interleukin-6 production [GO:0032675]; regulation of interleukin-8 production [GO:0032677]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; cytokine binding [GO:0019955]; cytokine receptor binding [GO:0005126]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; cytokine binding [GO:0019955]; cytokine receptor binding [GO:0005126]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; adaptive immune response [GO:0002250]; cartilage development [GO:0051216]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; negative regulation of angiogenesis [GO:0016525]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lymphotoxin A production [GO:0032761]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of granulocyte macrophage colony-stimulating factor production [GO:0032645]; regulation of interleukin-2 production [GO:0032663]; regulation of interleukin-6 production [GO:0032675]; regulation of interleukin-8 production [GO:0032677]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q7TNI7}.
Q96PD5	reviewed	PGRP2_HUMAN	N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) (Peptidoglycan recognition protein 2) (Peptidoglycan recognition protein long) (PGRP-L)	PGLYRP2 PGLYRPL PGRPL UNQ3103/PRO10102	Homo sapiens (Human)	576	FUNCTION: May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity. {ECO:0000269|PubMed:14506276}.	MISCELLANEOUS: [Isoform 1]: Major isoform.; MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	biological process involved in interaction with host [GO:0051701]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; innate immune response [GO:0045087]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; negative regulation of type II interferon production [GO:0032689]; peptide amidation [GO:0001519]; peptidoglycan catabolic process [GO:0009253]; regulation of inflammatory response [GO:0050727]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]	N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; zinc ion binding [GO:0008270]; biological process involved in interaction with host [GO:0051701]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; innate immune response [GO:0045087]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; negative regulation of type II interferon production [GO:0032689]; peptide amidation [GO:0001519]; peptidoglycan catabolic process [GO:0009253]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Secreted. Membrane.
Q96PD6	reviewed	MOGT1_HUMAN	2-acylglycerol O-acyltransferase 1 (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 1) (MGAT1) (Diacylglycerol O-acyltransferase candidate 2) (hDC2) (Diacylglycerol acyltransferase 2-like protein 1) (Monoacylglycerol O-acyltransferase 1)	MOGAT1 DC2 DGAT2L1	Homo sapiens (Human)	335	FUNCTION: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine. {ECO:0000250|UniProtKB:Q91ZV4}.		diacylglycerol biosynthetic process [GO:0006651]; glycerol metabolic process [GO:0006071]; triglyceride biosynthetic process [GO:0019432]	endoplasmic reticulum membrane [GO:0005789]	2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]	endoplasmic reticulum membrane [GO:0005789]; 2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]; diacylglycerol biosynthetic process [GO:0006651]; glycerol metabolic process [GO:0006071]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91ZV4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91ZV4}.
Q96PD7	reviewed	DGAT2_HUMAN	Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase 2)	DGAT2 HMFN1045 UNQ738/PRO1433	Homo sapiens (Human)	388	FUNCTION: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed:27184406). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000250|UniProtKB:Q9DCV3, ECO:0000269|PubMed:27184406, ECO:0000269|PubMed:28420705}.		cellular response to oleic acid [GO:0071400]; cholesterol homeostasis [GO:0042632]; diacylglycerol biosynthetic process [GO:0006651]; diacylglycerol metabolic process [GO:0046339]; fat pad development [GO:0060613]; fatty acid homeostasis [GO:0055089]; glycerol metabolic process [GO:0006071]; intracellular triglyceride homeostasis [GO:0035356]; lipid storage [GO:0019915]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; low-density lipoprotein particle clearance [GO:0034383]; monoacylglycerol biosynthetic process [GO:0006640]; regulation of plasma lipoprotein particle levels [GO:0097006]; triglyceride biosynthetic process [GO:0019432]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrion [GO:0005739]; perinuclear endoplasmic reticulum membrane [GO:1990578]; perinuclear region of cytoplasm [GO:0048471]	2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]; protein homodimerization activity [GO:0042803]; retinol O-fatty-acyltransferase activity [GO:0050252]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrion [GO:0005739]; perinuclear endoplasmic reticulum membrane [GO:1990578]; perinuclear region of cytoplasm [GO:0048471]; 2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]; protein homodimerization activity [GO:0042803]; retinol O-fatty-acyltransferase activity [GO:0050252]; cellular response to oleic acid [GO:0071400]; cholesterol homeostasis [GO:0042632]; diacylglycerol biosynthetic process [GO:0006651]; diacylglycerol metabolic process [GO:0046339]; fat pad development [GO:0060613]; fatty acid homeostasis [GO:0055089]; glycerol metabolic process [GO:0006071]; intracellular triglyceride homeostasis [GO:0035356]; lipid storage [GO:0019915]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; low-density lipoprotein particle clearance [GO:0034383]; monoacylglycerol biosynthetic process [GO:0006640]; regulation of plasma lipoprotein particle levels [GO:0097006]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14521909, ECO:0000269|PubMed:27184406}; Multi-pass membrane protein {ECO:0000269|PubMed:14521909}. Lipid droplet {ECO:0000269|PubMed:27184406}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27184406}.
Q96PE1	reviewed	AGRA2_HUMAN	Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5)	ADGRA2 GPR124 KIAA1531 TEM5	Homo sapiens (Human)	1338	FUNCTION: Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314}.		canonical Wnt signaling pathway [GO:0060070]; cell surface receptor signaling pathway [GO:0007166]; central nervous system development [GO:0007417]; endothelial cell migration [GO:0043542]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endothelial cell migration [GO:0010595]; regulation of angiogenesis [GO:0045765]; regulation of chemotaxis [GO:0050920]; regulation of establishment of blood-brain barrier [GO:0090210]; sprouting angiogenesis [GO:0002040]	cell surface [GO:0009986]; filopodium [GO:0030175]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909]	G protein-coupled receptor activity [GO:0004930]	cell surface [GO:0009986]; filopodium [GO:0030175]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909]; G protein-coupled receptor activity [GO:0004930]; canonical Wnt signaling pathway [GO:0060070]; cell surface receptor signaling pathway [GO:0007166]; central nervous system development [GO:0007417]; endothelial cell migration [GO:0043542]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endothelial cell migration [GO:0010595]; regulation of angiogenesis [GO:0045765]; regulation of chemotaxis [GO:0050920]; regulation of establishment of blood-brain barrier [GO:0090210]; sprouting angiogenesis [GO:0002040]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:21421844, ECO:0000269|PubMed:22013897}; Multi-pass membrane protein {ECO:0000255}. Cell projection, filopodium {ECO:0000269|PubMed:21421844}. Note=Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact. {ECO:0000269|PubMed:21421844}.
Q96PE3	reviewed	INP4A_HUMAN	Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66)	INPP4A	Homo sapiens (Human)	977	FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:20463662, PubMed:15716355). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:30071275) (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). {ECO:0000250|UniProtKB:Q62784, ECO:0000250|UniProtKB:Q9EPW0, ECO:0000269|PubMed:15716355, ECO:0000269|PubMed:20463662, ECO:0000269|PubMed:30071275}.; FUNCTION: [Isoform 4]: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3. {ECO:0000269|PubMed:9295334}.	MISCELLANEOUS: [Isoform 4]: Inactive. {ECO:0000305}.	inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol biosynthetic process [GO:0006661]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; recycling endosome membrane [GO:0055038]	inositol-1,3,4-trisphosphate 4-phosphatase activity [GO:0017161]; inositol-3,4-bisphosphate 4-phosphatase activity [GO:0052828]; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity [GO:0016316]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; recycling endosome membrane [GO:0055038]; inositol-1,3,4-trisphosphate 4-phosphatase activity [GO:0017161]; inositol-3,4-bisphosphate 4-phosphatase activity [GO:0052828]; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity [GO:0016316]; inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol biosynthetic process [GO:0006661]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:15716355}. Recycling endosome membrane {ECO:0000269|PubMed:15716355}. Cell membrane {ECO:0000269|PubMed:15716355}. Nucleus {ECO:0000269|PubMed:30071275}. Cytoplasm {ECO:0000269|PubMed:30071275}. Postsynaptic density {ECO:0000250|UniProtKB:Q9EPW0}. Note=Translocates to the plasma membrane upon EGF stimulation (PubMed:15716355). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (PubMed:30071275). {ECO:0000269|PubMed:15716355, ECO:0000269|PubMed:30071275}.
Q96PE7	reviewed	MCEE_HUMAN	Methylmalonyl-CoA epimerase, mitochondrial (EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)	MCEE	Homo sapiens (Human)	176	FUNCTION: Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism. {ECO:0000269|PubMed:11481338}.		L-methylmalonyl-CoA metabolic process [GO:0046491]; short-chain fatty acid catabolic process [GO:0019626]	mitochondrial matrix [GO:0005759]	metal ion binding [GO:0046872]; methylmalonyl-CoA epimerase activity [GO:0004493]	mitochondrial matrix [GO:0005759]; metal ion binding [GO:0046872]; methylmalonyl-CoA epimerase activity [GO:0004493]; L-methylmalonyl-CoA metabolic process [GO:0046491]; short-chain fatty acid catabolic process [GO:0019626]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q96PF1	reviewed	TGM7_HUMAN	Protein-glutamine gamma-glutamyltransferase Z (Transglutaminase Z) (TG(Z)) (TGZ) (TGase Z) (EC 2.3.2.13) (Transglutaminase-7) (TGase-7)	TGM7	Homo sapiens (Human)	710	FUNCTION: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.				metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	
Q96PF2	reviewed	TSSK2_HUMAN	Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B)	TSSK2 DGSG SPOGA2 STK22B	Homo sapiens (Human)	358	FUNCTION: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}.	MISCELLANEOUS: TSSK1B might be used as a target for male contraception or and intra-vaginal spermicides. {ECO:0000305|PubMed:17566264}.	cellular response to glucose starvation [GO:0042149]; intracellular signal transduction [GO:0035556]; negative regulation of TOR signaling [GO:0032007]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286]	acrosomal vesicle [GO:0001669]; centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; cellular response to glucose starvation [GO:0042149]; intracellular signal transduction [GO:0035556]; negative regulation of TOR signaling [GO:0032007]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:18495105}. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity). In spermatids, concentrates in centrioles during flagellogenesis. {ECO:0000250}.
Q96PG8	reviewed	BBC3B_HUMAN	Bcl-2-binding component 3, isoforms 3/4 (JFY-1) (p53 up-regulated modulator of apoptosis)	BBC3 PUMA	Homo sapiens (Human)	261	FUNCTION: [Isoform 3]: Does not affect cell growth. {ECO:0000269|PubMed:11463392}.		apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; release of cytochrome c from mitochondria [GO:0001836]	mitochondrion [GO:0005739]	ATPase binding [GO:0051117]	mitochondrion [GO:0005739]; ATPase binding [GO:0051117]; apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; release of cytochrome c from mitochondria [GO:0001836]	SUBCELLULAR LOCATION: Note=Contrary to isoforms 1 and 2, isoform 3 does not localize to the mitochondria.
Q96PH1	reviewed	NOX5_HUMAN	NADPH oxidase 5 (EC 1.6.3.-)	NOX5	Homo sapiens (Human)	765	FUNCTION: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:12686516). May play a role in cell growth and apoptosis (PubMed:12686516). {ECO:0000269|PubMed:12686516}.; FUNCTION: [Isoform v2]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:11483596, PubMed:14982937, PubMed:17275676, PubMed:21642394, PubMed:24505490, PubMed:36653838, PubMed:17587483, PubMed:22427510, PubMed:22387196). Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa (PubMed:11483596). Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin (PubMed:17275676). {ECO:0000269|PubMed:11483596, ECO:0000269|PubMed:14982937, ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:17587483, ECO:0000269|PubMed:21642394, ECO:0000269|PubMed:22387196, ECO:0000269|PubMed:22427510, ECO:0000269|PubMed:24505490, ECO:0000269|PubMed:36653838}.; FUNCTION: [Isoform v1]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269|PubMed:21319793, ECO:0000269|PubMed:22427510}.; FUNCTION: [Isoform v5]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:17275676, PubMed:36653838). According to PubMed:22427510, lacks enzyme activity (PubMed:22427510). Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin (PubMed:17275676). {ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:22427510, ECO:0000269|PubMed:36653838}.; FUNCTION: [Isoform v4]: Lacks calcium-dependent NADPH oxidase activity. {ECO:0000269|PubMed:22427510}.; FUNCTION: [Isoform v3]: Lacks calcium-dependent NADPH oxidase activity. {ECO:0000269|PubMed:22427510}.		angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cytoskeleton-dependent cytokinesis [GO:0061640]; defense response [GO:0006952]; endothelial cell proliferation [GO:0001935]; positive regulation of cytokine production [GO:0001819]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; proton transmembrane transport [GO:1902600]; regulation of fusion of sperm to egg plasma membrane [GO:0043012]; superoxide anion generation [GO:0042554]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; NADP binding [GO:0050661]; proton channel activity [GO:0015252]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; NADP binding [GO:0050661]; proton channel activity [GO:0015252]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cytoskeleton-dependent cytokinesis [GO:0061640]; defense response [GO:0006952]; endothelial cell proliferation [GO:0001935]; positive regulation of cytokine production [GO:0001819]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; proton transmembrane transport [GO:1902600]; regulation of fusion of sperm to egg plasma membrane [GO:0043012]; superoxide anion generation [GO:0042554]	SUBCELLULAR LOCATION: [Isoform v2]: Endoplasmic reticulum {ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:17587483}. Cell membrane {ECO:0000269|PubMed:17587483, ECO:0000269|PubMed:36653838}; Multi-pass membrane protein {ECO:0000255}. Note=Calcium-sensitive association and dissociation between the N- and C-terminal domains appears to facilitate its localization to the cell membrane. {ECO:0000269|PubMed:36653838}.; SUBCELLULAR LOCATION: [Isoform v5]: Endoplasmic reticulum {ECO:0000269|PubMed:17275676}.
Q96PH6	reviewed	DB118_HUMAN	Defensin beta 118 (Beta-defensin 18) (DEFB-18) (Epididymal secretory protein 13.6) (ESP13.6)	DEFB118 C20orf63 DEFB18 ESC42	Homo sapiens (Human)	123	FUNCTION: Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis (PubMed:15033915, PubMed:33224970). Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes (PubMed:33224970). Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface (PubMed:15033915). Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization (PubMed:33181266). May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms (PubMed:15033915). {ECO:0000269|PubMed:15033915, ECO:0000269|PubMed:33181266, ECO:0000269|PubMed:33224970}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-matrix adhesion [GO:0007160]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; negative regulation of cell adhesion [GO:0007162]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; spermatogenesis [GO:0007283]	extracellular region [GO:0005576]	lipopolysaccharide binding [GO:0001530]; membrane destabilizing activity [GO:0140912]	extracellular region [GO:0005576]; lipopolysaccharide binding [GO:0001530]; membrane destabilizing activity [GO:0140912]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-matrix adhesion [GO:0007160]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; negative regulation of cell adhesion [GO:0007162]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12600824}.
Q96PJ5	reviewed	FCRL4_HUMAN	Fc receptor-like protein 4 (FcR-like protein 4) (FcRL4) (Fc receptor homolog 4) (FcRH4) (IFGP family protein 2) (hIFGP2) (Immune receptor translocation-associated protein 1) (CD antigen CD307d)	FCRL4 FCRH4 IFGP2 IRTA1	Homo sapiens (Human)	515	FUNCTION: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. {ECO:0000269|PubMed:14597715}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16157685, ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16157685, ECO:0000269|PubMed:16849395}.
Q96PK6	reviewed	RBM14_HUMAN	RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein)	RBM14 SIP	Homo sapiens (Human)	669	FUNCTION: Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728}.		activation of innate immune response [GO:0002218]; centriole assembly [GO:0098534]; innate immune response [GO:0045087]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of centriole replication [GO:0046600]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to hormone [GO:0009725]; SMAD protein signal transduction [GO:0060395]; transcription initiation-coupled chromatin remodeling [GO:0045815]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; transcription regulator complex [GO:0005667]	nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; transcription regulator complex [GO:0005667]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; activation of innate immune response [GO:0002218]; centriole assembly [GO:0098534]; innate immune response [GO:0045087]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of centriole replication [GO:0046600]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to hormone [GO:0009725]; SMAD protein signal transduction [GO:0060395]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25385835}. Nucleus, nucleolus {ECO:0000269|PubMed:11790299}. Cytoplasm {ECO:0000269|PubMed:25385835}. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles (PubMed:11790299). Cytoplasmic localization is crucial for its function in suppressing the formation of aberrant centriolar protein complexes (PubMed:25385835). {ECO:0000269|PubMed:11790299, ECO:0000269|PubMed:25385835}.
Q96PL5	reviewed	ERMAP_HUMAN	Erythroid membrane-associated protein (hERMAP) (Radin blood group antigen) (Scianna blood group antigen)	ERMAP RD SC	Homo sapiens (Human)	475	FUNCTION: Possible role as a cell-adhesion or receptor molecule of erythroid cells.		regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	signaling receptor binding [GO:0005102]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; signaling receptor binding [GO:0005102]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11783959}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:11783959}.
Q96PM5	reviewed	ZN363_HUMAN	RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin transferase RCHY1) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2)	RCHY1 ARNIP CHIMP PIRH2 RNF199 ZNF363	Homo sapiens (Human)	261	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:19483087, PubMed:19043414, PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:21994467). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (PubMed:19483087, PubMed:19043414). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:21791603). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (PubMed:33909987). {ECO:0000269|PubMed:16914734, ECO:0000269|PubMed:17721809, ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19043414, ECO:0000269|PubMed:19483087, ECO:0000269|PubMed:21791603, ECO:0000269|PubMed:21994467, ECO:0000269|PubMed:33909987}.; FUNCTION: [Isoform 4]: Has no E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20452352}.	MISCELLANEOUS: [Isoform 7]: Gene prediction based on partial mRNA data. {ECO:0000305}.	error-free translesion synthesis [GO:0070987]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; error-free translesion synthesis [GO:0070987]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16914734, ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19483087}. Nucleus speckle {ECO:0000269|PubMed:14701804}. Cytoplasm {ECO:0000269|PubMed:15781263, ECO:0000269|PubMed:18006823}.
Q96PM9	reviewed	Z385A_HUMAN	Zinc finger protein 385A (Hematopoietic zinc finger protein) (Retinal zinc finger protein)	ZNF385A HZF RZF ZNF385	Homo sapiens (Human)	386	FUNCTION: RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. {ECO:0000269|PubMed:17719541}.		apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; hemostasis [GO:0007599]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; megakaryocyte development [GO:0035855]; mRNA localization resulting in post-transcriptional regulation of gene expression [GO:0010609]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; platelet alpha granule organization [GO:0070889]; platelet formation [GO:0030220]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of fat cell differentiation [GO:0045600]; regulation of cytoplasmic translation [GO:2000765]	cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; hemostasis [GO:0007599]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; megakaryocyte development [GO:0035855]; mRNA localization resulting in post-transcriptional regulation of gene expression [GO:0010609]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; platelet alpha granule organization [GO:0070889]; platelet formation [GO:0030220]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of fat cell differentiation [GO:0045600]; regulation of cytoplasmic translation [GO:2000765]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15527981}. Nucleus, nucleolus {ECO:0000269|PubMed:15527981}. Cell projection, dendrite {ECO:0000250}. Note=Detected in dendrites of Purkinje cells and hippocampal neurons. {ECO:0000250}.
Q96PN6	reviewed	ADCYA_HUMAN	Adenylate cyclase type 10 (EC 4.6.1.1) (AH-related protein) (Adenylate cyclase homolog) (Germ cell soluble adenylyl cyclase) (hsAC) (sAC) (Testicular soluble adenylyl cyclase)	ADCY10 SAC	Homo sapiens (Human)	1610	FUNCTION: Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988). {ECO:0000250|UniProtKB:Q8C0T9, ECO:0000269|PubMed:15659711, ECO:0000269|PubMed:17591988, ECO:0000269|PubMed:24567411, ECO:0000269|PubMed:24616449, ECO:0000269|PubMed:25040695}.		cAMP biosynthetic process [GO:0006171]; cellular response to inorganic substance [GO:0071241]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; glucose catabolic process [GO:0006007]; intracellular signal transduction [GO:0035556]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of cardiac muscle cell contraction [GO:0106135]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection extension [GO:1990138]; neuron projection maintenance [GO:1990535]; neuron projection retraction [GO:0106028]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of axon extension [GO:0045773]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of glycogen catabolic process [GO:0045819]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of ossification [GO:0045778]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; regulation of membrane repolarization [GO:0060306]; regulation of mitophagy [GO:1901524]; spermatid development [GO:0007286]	apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; basal part of cell [GO:0045178]; central region of growth cone [GO:0090724]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; bicarbonate binding [GO:0071890]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]	apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; basal part of cell [GO:0045178]; central region of growth cone [GO:0090724]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; bicarbonate binding [GO:0071890]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; cAMP biosynthetic process [GO:0006171]; cellular response to inorganic substance [GO:0071241]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; glucose catabolic process [GO:0006007]; intracellular signal transduction [GO:0035556]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of cardiac muscle cell contraction [GO:0106135]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection extension [GO:1990138]; neuron projection maintenance [GO:1990535]; neuron projection retraction [GO:0106028]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of axon extension [GO:0045773]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of glycogen catabolic process [GO:0045819]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of ossification [GO:0045778]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; regulation of membrane repolarization [GO:0060306]; regulation of mitophagy [GO:1901524]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15659711}; Peripheral membrane protein {ECO:0000269|PubMed:15659711}; Cytoplasmic side {ECO:0000269|PubMed:15659711}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12475901, ECO:0000269|PubMed:15659711}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12475901, ECO:0000269|PubMed:15659711}. Nucleus {ECO:0000269|PubMed:12475901, ECO:0000269|PubMed:15659711}. Cell projection, cilium {ECO:0000269|PubMed:17591988}. Cytoplasm {ECO:0000269|PubMed:12475901}. Mitochondrion {ECO:0000269|PubMed:12475901}. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin. {ECO:0000269|PubMed:12475901, ECO:0000269|PubMed:15659711}.
Q96PN7	reviewed	TREF1_HUMAN	Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132)	TRERF1 BCAR2 RAPA TREP132	Homo sapiens (Human)	1200	FUNCTION: Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}.		cellular response to progesterone stimulus [GO:0071393]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear progesterone receptor binding [GO:0033142]; nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription corepressor activity [GO:0003714]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear progesterone receptor binding [GO:0033142]; nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription corepressor activity [GO:0003714]; cellular response to progesterone stimulus [GO:0071393]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}.
Q96PN8	reviewed	TSSK3_HUMAN	Testis-specific serine/threonine-protein kinase 3 (TSK-3) (TSSK-3) (Testis-specific kinase 3) (EC 2.7.11.1) (Serine/threonine-protein kinase 22C)	TSSK3 SPOGA3 STK22C	Homo sapiens (Human)	268	FUNCTION: May be involved in a signaling pathway during male germ cell development or mature sperm function.	MISCELLANEOUS: The mouse homolog is Stk22d.	cell differentiation [GO:0030154]; cellular response to glucose starvation [GO:0042149]; intracellular signal transduction [GO:0035556]; negative regulation of TOR signaling [GO:0032007]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283]	nucleotide-activated protein kinase complex [GO:0031588]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	nucleotide-activated protein kinase complex [GO:0031588]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell differentiation [GO:0030154]; cellular response to glucose starvation [GO:0042149]; intracellular signal transduction [GO:0035556]; negative regulation of TOR signaling [GO:0032007]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283]	
Q96PP8	reviewed	GBP5_HUMAN	Guanylate-binding protein 5 (EC 3.6.5.-) (GBP-TA antigen) (GTP-binding protein 5) (GBP-5) (Guanine nucleotide-binding protein 5)	GBP5 UNQ2427/PRO4987	Homo sapiens (Human)	586	FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:26996307, PubMed:31091448). {ECO:0000250|UniProtKB:Q8CFB4, ECO:0000269|PubMed:20180847, ECO:0000269|PubMed:22461501, ECO:0000269|PubMed:26996307, ECO:0000269|PubMed:31091448}.; FUNCTION: Antigenic tumor-specific truncated splice form. {ECO:0000269|PubMed:15175044}.		activation of innate immune response [GO:0002218]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; positive regulation of AIM2 inflammasome complex assembly [GO:0140973]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of pyroptosis [GO:0140639]; protein homotetramerization [GO:0051289]; protein localization to Golgi apparatus [GO:0034067]; protein targeting [GO:0006605]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; side of membrane [GO:0098552]; symbiont cell surface [GO:0106139]	endopeptidase inhibitor activity [GO:0004866]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; side of membrane [GO:0098552]; symbiont cell surface [GO:0106139]; endopeptidase inhibitor activity [GO:0004866]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; protein homodimerization activity [GO:0042803]; activation of innate immune response [GO:0002218]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; positive regulation of AIM2 inflammasome complex assembly [GO:0140973]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of pyroptosis [GO:0140639]; protein homotetramerization [GO:0051289]; protein localization to Golgi apparatus [GO:0034067]; protein targeting [GO:0006605]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8CFB4}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:21151871}. Golgi apparatus membrane {ECO:0000269|PubMed:17266443, ECO:0000269|PubMed:21151871, ECO:0000269|PubMed:26996307, ECO:0000269|PubMed:31091448}; Lipid-anchor {ECO:0000269|PubMed:21151871}. Cytoplasm {ECO:0000269|PubMed:17266443, ECO:0000269|PubMed:21151871}.
Q96PP9	reviewed	GBP4_HUMAN	Guanylate-binding protein 4 (EC 3.6.5.-) (GTP-binding protein 4) (GBP-4) (Guanine nucleotide-binding protein 4)	GBP4	Homo sapiens (Human)	640	FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor (By similarity). {ECO:0000250|UniProtKB:A4UUI3}.		cellular response to type II interferon [GO:0071346]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; cellular response to type II interferon [GO:0071346]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:21151871}. Cytoplasm {ECO:0000269|PubMed:17266443}. Nucleus {ECO:0000269|PubMed:17266443}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21151871}. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. {ECO:0000269|PubMed:21151871}.
Q96PQ0	reviewed	SORC2_HUMAN	VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain]	SORCS2 KIAA1329	Homo sapiens (Human)	1159	FUNCTION: The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:22155786, PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814). Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (PubMed:22155786). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q9EPR5, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:27457814}.; FUNCTION: [SorCS2 122 kDa chain]: Does not promote Schwann cell apoptosis in response to proBDNF. {ECO:0000269|PubMed:24908487}.; FUNCTION: SorCS2 104 kDa chain and SorCS2 18 kDa chain together promote Schwann cell apoptosis in response to proBDNF. {ECO:0000269|PubMed:24908487}.	MISCELLANEOUS: Expression is decreased in the brains of Huntington disease (HD) patients after the onset of symptoms. {ECO:0000269|PubMed:28469074}.	intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; neuropeptide signaling pathway [GO:0007218]	cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perikaryon [GO:0043204]; postsynaptic density membrane [GO:0098839]; recycling endosome membrane [GO:0055038]	neuropeptide receptor activity [GO:0008188]	cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perikaryon [GO:0043204]; postsynaptic density membrane [GO:0098839]; recycling endosome membrane [GO:0055038]; neuropeptide receptor activity [GO:0008188]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:24908487}; Single-pass type I membrane protein {ECO:0000269|PubMed:24908487}. Cell projection {ECO:0000250|UniProtKB:Q9EPR5}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:24908487}; Single-pass type I membrane protein {ECO:0000269|PubMed:24908487}. Early endosome membrane {ECO:0000250|UniProtKB:Q9EPR5}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9EPR5}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q9EPR5}. Perikaryon {ECO:0000269|PubMed:28469074}. Cell projection, dendrite {ECO:0000269|PubMed:28469074}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9EPR5}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q9EPR5}.
Q96PQ1	reviewed	SIG12_HUMAN	Sialic acid-binding Ig-like lectin 12 (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1)	SIGLEC12 SIGLECL1 SLG UNQ9215/PRO34042	Homo sapiens (Human)	595	FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.		cell adhesion [GO:0007155]	plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]	plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q96PQ6	reviewed	ZN317_HUMAN	Zinc finger protein 317	ZNF317 KIAA1588	Homo sapiens (Human)	595	FUNCTION: May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96PR1	reviewed	KCNC2_HUMAN	Potassium voltage-gated channel subfamily C member 2 (Shaw-like potassium channel) (Voltage-gated potassium channel Kv3.2)	KCNC2	Homo sapiens (Human)	638	FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15709110). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:15709110). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity). {ECO:0000250|UniProtKB:P22462, ECO:0000250|UniProtKB:Q14B80, ECO:0000269|PubMed:15709110, ECO:0000305|PubMed:10414303, ECO:0000305|PubMed:11506885}.		action potential [GO:0001508]; cellular response to ammonium ion [GO:0071242]; cellular response to nitric oxide [GO:0071732]; cellular response to toxic substance [GO:0097237]; globus pallidus development [GO:0021759]; nitric oxide-cGMP-mediated signaling pathway [GO:0038060]; optic nerve development [GO:0021554]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transmembrane transport [GO:0071805]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; response to amine [GO:0014075]; response to ethanol [GO:0045471]; response to light intensity [GO:0009642]; response to magnesium ion [GO:0032026]; response to nerve growth factor [GO:1990089]; response to organic cyclic compound [GO:0014070]	apical plasma membrane [GO:0016324]; axolemma [GO:0030673]; axon [GO:0030424]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; terminal bouton [GO:0043195]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]	apical plasma membrane [GO:0016324]; axolemma [GO:0030673]; axon [GO:0030424]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; terminal bouton [GO:0043195]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]; action potential [GO:0001508]; cellular response to ammonium ion [GO:0071242]; cellular response to nitric oxide [GO:0071732]; cellular response to toxic substance [GO:0097237]; globus pallidus development [GO:0021759]; nitric oxide-cGMP-mediated signaling pathway [GO:0038060]; optic nerve development [GO:0021554]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transmembrane transport [GO:0071805]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; response to amine [GO:0014075]; response to ethanol [GO:0045471]; response to light intensity [GO:0009642]; response to magnesium ion [GO:0032026]; response to nerve growth factor [GO:1990089]; response to organic cyclic compound [GO:0014070]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15709110}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:Q14B80}; Multi-pass membrane protein {ECO:0000255}. Perikaryon {ECO:0000250|UniProtKB:Q14B80}. Cell projection, axon {ECO:0000250|UniProtKB:Q14B80}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q14B80}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q14B80}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q14B80}. Synapse, synaptosome {ECO:0000250|UniProtKB:P22462}. Synapse {ECO:0000250|UniProtKB:P22462}. Apical cell membrane {ECO:0000250|UniProtKB:P22462}. Basolateral cell membrane {ECO:0000250|UniProtKB:P22462}. Note=Colocalizes with parvalbumin in globus pallidus neurons. Localizes in thalamocortical axons and synapses. Localizes on the surface of cell somata, proximal dendrites and axonal membranes. Also detected throughout the neuropil. Localized in starburst cell somata and proximal dendrite processes. Colocalized with GABA in presynaptic terminals. Clustered in patches in somatic and proximal dendritic membrane as well as in axons and presnypatic terminals of GABAergic interneurons; some of these patches are found near postsynaptic sites. {ECO:0000250|UniProtKB:P22462, ECO:0000250|UniProtKB:Q14B80}.
Q96PS8	reviewed	AQP10_HUMAN	Aquaporin-10 (AQP-10) (Aquaglyceroporin-10) (Small intestine aquaporin)	AQP10	Homo sapiens (Human)	301	FUNCTION: [Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH (PubMed:12084581, PubMed:21733844, PubMed:23382902, PubMed:30420639). The channel is permeable to glycerol, especially when the cytosolic pH is acidified (PubMed:21733844, PubMed:30420639). Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation (PubMed:23382902). May contribute to water transport in the intestine (Probable). {ECO:0000269|PubMed:12084581, ECO:0000269|PubMed:21733844, ECO:0000269|PubMed:23382902, ECO:0000269|PubMed:30420639, ECO:0000305|PubMed:11573934, ECO:0000305|PubMed:12084581, ECO:0000305|PubMed:15221416}.; FUNCTION: [Isoform 2]: Water channel that mediates water transport across cell membranes, but that is not permeable to glycerol. {ECO:0000269|PubMed:11573934}.		cellular response to acidic pH [GO:0071468]; glycerol transmembrane transport [GO:0015793]; protein homotetramerization [GO:0051289]; response to toxic substance [GO:0009636]; water transport [GO:0006833]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]	glycerol channel activity [GO:0015254]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]; glycerol channel activity [GO:0015254]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250]; cellular response to acidic pH [GO:0071468]; glycerol transmembrane transport [GO:0015793]; protein homotetramerization [GO:0051289]; response to toxic substance [GO:0009636]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:15221416}; Multi-pass membrane protein {ECO:0000269|PubMed:30420639}. Cell membrane {ECO:0000269|PubMed:11573934, ECO:0000269|PubMed:12084581, ECO:0000269|PubMed:23382902, ECO:0000269|PubMed:30420639}; Multi-pass membrane protein {ECO:0000269|PubMed:30420639}. Lipid droplet {ECO:0000269|PubMed:23382902}. Note=Detected around lipid droplets. {ECO:0000269|PubMed:23382902}.
Q96PU4	reviewed	UHRF2_HUMAN	E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2)	UHRF2 NIRF RNF107	Homo sapiens (Human)	802	FUNCTION: E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair (PubMed:15178429, PubMed:29506131, PubMed:27743347, PubMed:23404503). Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:27129234, PubMed:24813944). This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest (PubMed:15178429, PubMed:15361834, PubMed:21952639). Ubiquitinates also PCNP leading to its degradation by the proteasome (PubMed:14741369, PubMed:12176013). Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation (PubMed:29923055). Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation (PubMed:30335751). Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (PubMed:33848395). {ECO:0000250|UniProtKB:Q7TMI3, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:14741369, ECO:0000269|PubMed:15178429, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:21952639, ECO:0000269|PubMed:23404503, ECO:0000269|PubMed:24813944, ECO:0000269|PubMed:27129234, ECO:0000269|PubMed:27743347, ECO:0000269|PubMed:29506131, ECO:0000269|PubMed:29923055, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:33848395}.		cell cycle [GO:0007049]; cell differentiation [GO:0030154]; protein autoubiquitination [GO:0051865]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]	heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	DNA binding [GO:0003677]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; DNA binding [GO:0003677]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; protein autoubiquitination [GO:0051865]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00358, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:23404503, ECO:0000269|PubMed:27129234, ECO:0000269|PubMed:27743347, ECO:0000269|PubMed:29923055, ECO:0000269|PubMed:30335751}. Chromosome {ECO:0000269|PubMed:27129234}. Note=Enriched at genomic loci that are enriched for 5-hydroxymethylcytosine (5hmC). {ECO:0000269|PubMed:27129234}.
Q96PU5	reviewed	NED4L_HUMAN	E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)	NEDD4L KIAA0439 NEDL3	Homo sapiens (Human)	975	FUNCTION: E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:31959741, PubMed:33608556, PubMed:20064473). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}.		cell differentiation [GO:0030154]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sodium ion transmembrane transport [GO:1902306]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of dendrite extension [GO:1903861]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of membrane repolarization [GO:0060306]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; regulation of protein stability [GO:0031647]; regulation of sodium ion transmembrane transport [GO:1902305]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular cardiac muscle cell action potential [GO:0086005]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]	potassium channel inhibitor activity [GO:0019870]; potassium channel regulator activity [GO:0015459]; sodium channel inhibitor activity [GO:0019871]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; potassium channel inhibitor activity [GO:0019870]; potassium channel regulator activity [GO:0015459]; sodium channel inhibitor activity [GO:0019871]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cell differentiation [GO:0030154]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sodium ion transmembrane transport [GO:1902306]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of dendrite extension [GO:1903861]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of membrane repolarization [GO:0060306]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; regulation of protein stability [GO:0031647]; regulation of sodium ion transmembrane transport [GO:1902305]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:18819914, ECO:0000269|PubMed:27694961}. Golgi apparatus {ECO:0000269|PubMed:26363003}. Endosome, multivesicular body {ECO:0000269|PubMed:26363003}. Note=May be recruited to exosomes by NDFIP1.
Q96PU8	reviewed	QKI_HUMAN	KH domain-containing RNA-binding protein QKI (Protein quaking) (Hqk) (HqkI)	QKI HKQ	Homo sapiens (Human)	341	FUNCTION: RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (PubMed:22398723, PubMed:25768908, PubMed:27029405, PubMed:31331967, PubMed:23630077, PubMed:37379838). Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development (PubMed:25768908, PubMed:31829086, PubMed:34428287, PubMed:37379838). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (PubMed:23630077). Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons (PubMed:25768908). CircRNAs are produced by back-splicing circularization of pre-mRNAs (PubMed:25768908). Plays a central role in myelinization via 3 distinct mechanisms (PubMed:16641098). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation (By similarity). Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA (By similarity). Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation (By similarity). Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (PubMed:27029405). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts (By similarity). Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1 (By similarity). Also required for visceral endoderm function and blood vessel development (By similarity). May also play a role in smooth muscle development (PubMed:31331967). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:16641098, ECO:0000269|PubMed:22398723, ECO:0000269|PubMed:23630077, ECO:0000269|PubMed:25768908, ECO:0000269|PubMed:27029405, ECO:0000269|PubMed:31331967, ECO:0000269|PubMed:31829086, ECO:0000269|PubMed:34428287, ECO:0000269|PubMed:37379838}.; FUNCTION: [Isoform QKI5]: Nuclear isoform that acts as an indirect regulator of mRNA splicing (By similarity). Regulates mRNA splicing of MAG pre-mRNA by inhibiting translation of HNRNPA1 mRNA, thereby preventing MAG exon 12 alternative splicing (By similarity). Involved in oligodendrocyte differentiation by promoting stabilization of SIRT2 mRNA (By similarity). Acts as a negative regulator of the interferon response by binding to MAVS mRNA, downregulating its expression (PubMed:31829086). Also inhibits the interferon response by binding to fibrinectin FN1 pre-mRNA, repressing EDA exon inclusion in FN1 (PubMed:34428287). Delays macrophage differentiation by binding to CSF1R mRNA, promoting its degradation (PubMed:22398723). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2, promoting SREBF2/SREBP2-dependent cholesterol biosynthesis (By similarity). SREBF2/SREBP2-dependent cholesterol biosynthesis participates to myelinization and is required for eye lens transparency (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:22398723, ECO:0000269|PubMed:31829086, ECO:0000269|PubMed:34428287}.; FUNCTION: [Isoform QKI6]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (PubMed:37379838). Acts as a translational repressor for HNRNPA1 and GLI1 (By similarity). Translation inhibition of HNRNPA1 during oligodendrocyte differentiation prevents inclusion of exon 12 in MAG pre-mRNA splicing (By similarity). Involved in astrocyte differentiation by regulating translation of target mRNAs (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:37379838}.; FUNCTION: [Isoform QKI7]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (PubMed:37379838). Acts as a negative regulator of angiogenesis by binding to mRNAs encoding CDH5, NLGN1 and TNFAIP6, promoting their degradation (PubMed:32732889). Can also induce apoptosis in the cytoplasm (By similarity). Heterodimerization with other isoforms results in nuclear translocation of isoform QKI7 and suppression of apoptosis (By similarity). Also binds some microRNAs: promotes stabilitation of miR-122 by mediating recruitment of poly(A) RNA polymerase TENT2, leading to 3' adenylation and stabilization of miR-122 (PubMed:31792053). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:31792053, ECO:0000269|PubMed:32732889, ECO:0000269|PubMed:37379838}.		long-chain fatty acid biosynthetic process [GO:0042759]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; myelination [GO:0042552]; positive regulation of gene expression [GO:0010628]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]; spermatid development [GO:0007286]; vascular associated smooth muscle cell differentiation [GO:0035886]; vasculogenesis [GO:0001570]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; synapse [GO:0045202]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; synapse [GO:0045202]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]; long-chain fatty acid biosynthetic process [GO:0042759]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; myelination [GO:0042552]; positive regulation of gene expression [GO:0010628]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]; spermatid development [GO:0007286]; vascular associated smooth muscle cell differentiation [GO:0035886]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:37379838}. Cytoplasm {ECO:0000269|PubMed:37379838}.; SUBCELLULAR LOCATION: [Isoform QKI5]: Nucleus {ECO:0000269|PubMed:37379838}. Cytoplasm {ECO:0000269|PubMed:37379838}. Note=Localizes predominantly in the nucleus and at lower levels in cytoplasm (PubMed:37379838). It shuttles between the cytoplasm and the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:37379838}.; SUBCELLULAR LOCATION: [Isoform QKI6]: Cytoplasm, cytosol {ECO:0000269|PubMed:37379838}. Nucleus {ECO:0000269|PubMed:37379838}. Note=Localizes predominantly in the cytoplasm and at lower levels in nucleus. {ECO:0000269|PubMed:37379838}.; SUBCELLULAR LOCATION: [Isoform QKI7]: Cytoplasm, cytosol {ECO:0000269|PubMed:37379838}. Cytoplasm, Stress granule {ECO:0000269|PubMed:37379838}. Nucleus {ECO:0000269|PubMed:37379838}. Note=Localizes predominantly in the cytoplasm and at much lower levels in nucleus (PubMed:37379838). Shuttles between the cytosol and stress granules in response to stress (PubMed:37379838). {ECO:0000269|PubMed:37379838}.
Q96PV0	reviewed	SYGP1_HUMAN	Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)	SYNGAP1 KIAA1938	Homo sapiens (Human)	1343	FUNCTION: Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). {ECO:0000250}.		axonogenesis [GO:0007409]; dendrite development [GO:0016358]; maintenance of postsynaptic specialization structure [GO:0098880]; negative regulation of axonogenesis [GO:0050771]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of Ras protein signal transduction [GO:0046580]; neuron apoptotic process [GO:0051402]; pattern specification process [GO:0007389]; Ras protein signal transduction [GO:0007265]; receptor clustering [GO:0043113]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of MAPK cascade [GO:0043408]; regulation of synapse structure or activity [GO:0050803]; regulation of synaptic plasticity [GO:0048167]; visual learning [GO:0008542]	cytosol [GO:0005829]; dendritic shaft [GO:0043198]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]	cytosol [GO:0005829]; dendritic shaft [GO:0043198]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]; axonogenesis [GO:0007409]; dendrite development [GO:0016358]; maintenance of postsynaptic specialization structure [GO:0098880]; negative regulation of axonogenesis [GO:0050771]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of Ras protein signal transduction [GO:0046580]; neuron apoptotic process [GO:0051402]; pattern specification process [GO:0007389]; Ras protein signal transduction [GO:0007265]; receptor clustering [GO:0043113]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of MAPK cascade [GO:0043408]; regulation of synapse structure or activity [GO:0050803]; regulation of synaptic plasticity [GO:0048167]; visual learning [GO:0008542]	
Q96PV4	reviewed	PNMA5_HUMAN	Paraneoplastic antigen-like protein 5 (Tumor antigen BJ-HCC-25)	PNMA5 KIAA1934	Homo sapiens (Human)	448			positive regulation of apoptotic process [GO:0043065]		identical protein binding [GO:0042802]	identical protein binding [GO:0042802]; positive regulation of apoptotic process [GO:0043065]	
Q96PV6	reviewed	LENG8_HUMAN	Leukocyte receptor cluster member 8	LENG8 KIAA1932	Homo sapiens (Human)	800				nucleus [GO:0005634]; protein-containing complex [GO:0032991]		nucleus [GO:0005634]; protein-containing complex [GO:0032991]	
Q96PV7	reviewed	F193B_HUMAN	Protein FAM193B	FAM193B IRIZIO KIAA1931	Homo sapiens (Human)	902				cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21177767}. Nucleus {ECO:0000269|PubMed:21177767}. Note=Partly colocalized with an endoplasmic reticulum marker, HSP90B1. Shuttles between nucleus and cytoplasm.
Q96PX1	reviewed	RN157_HUMAN	E3 ubiquitin ligase RNF157 (EC 2.3.2.27) (RING finger protein 157) (RING-type E3 ubiquitin transferase RNF157)	RNF157 KIAA1917	Homo sapiens (Human)	679	FUNCTION: E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764). {ECO:0000269|PubMed:25342469, ECO:0000269|PubMed:28655764}.		negative regulation of apoptotic process [GO:0043066]; positive regulation of dendrite extension [GO:1903861]; protein ubiquitination [GO:0016567]	cell body [GO:0044297]; cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cell body [GO:0044297]; cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of apoptotic process [GO:0043066]; positive regulation of dendrite extension [GO:1903861]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:M0R5D6}.
Q96PX8	reviewed	SLIK1_HUMAN	SLIT and NTRK-like protein 1 (Leucine-rich repeat-containing protein 12)	SLITRK1 KIAA1910 LRRC12 UNQ233/PRO266	Homo sapiens (Human)	696	FUNCTION: It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Enhances neuronal dendrite outgrowth (PubMed:16224024, PubMed:19640509). {ECO:0000269|PubMed:16224024, ECO:0000269|PubMed:19640509, ECO:0000269|PubMed:27273464, ECO:0000269|PubMed:27812321}.		adult behavior [GO:0030534]; axonogenesis [GO:0007409]; homeostatic process [GO:0042592]; multicellular organism growth [GO:0035264]; positive regulation of axonogenesis [GO:0050772]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560]	extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; synapse [GO:0045202]		extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; synapse [GO:0045202]; adult behavior [GO:0030534]; axonogenesis [GO:0007409]; homeostatic process [GO:0042592]; multicellular organism growth [GO:0035264]; positive regulation of axonogenesis [GO:0050772]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:19640509}. Synapse {ECO:0000250|UniProtKB:Q810C1}.
Q96PY5	reviewed	FMNL2_HUMAN	Formin-like protein 2 (Formin homology 2 domain-containing protein 2)	FMNL2 FHOD2 KIAA1902	Homo sapiens (Human)	1086	FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}.		cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360]	cytosol [GO:0005829]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; small GTPase binding [GO:0031267]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96PY6	reviewed	NEK1_HUMAN	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55)	NEK1 KIAA1901	Homo sapiens (Human)	1258	FUNCTION: Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cilium assembly [GO:0060271]; protein phosphorylation [GO:0006468]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]	14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; cell cycle [GO:0007049]; cell division [GO:0051301]; cilium assembly [GO:0060271]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15604234, ECO:0000305|PubMed:21211617}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P51954}. Cytoplasm {ECO:0000269|PubMed:18843199}. Note=Associated with the pericentriolar material (PubMed:21211617). Localizes to centrosome during interphase and mitosis (By similarity). Translocated from cytoplasm to discrete nuclear foci at sites of DNA damage (PubMed:15604234). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:15604234, ECO:0000269|PubMed:21211617}.
Q96PZ0	reviewed	PUS7_HUMAN	Pseudouridylate synthase 7 homolog (EC 5.4.99.-)	PUS7 KIAA1897	Homo sapiens (Human)	661	FUNCTION: Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:35051350, PubMed:34718722). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:29628141, ECO:0000269|PubMed:30778726, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:34718722, ECO:0000269|PubMed:35051350}.		mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; negative regulation of translation [GO:0017148]; pseudouridine synthesis [GO:0001522]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of mesoderm development [GO:2000380]; RNA splicing [GO:0008380]; tRNA pseudouridine synthesis [GO:0031119]	nucleus [GO:0005634]	enzyme binding [GO:0019899]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]	nucleus [GO:0005634]; enzyme binding [GO:0019899]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; negative regulation of translation [GO:0017148]; pseudouridine synthesis [GO:0001522]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of mesoderm development [GO:2000380]; RNA splicing [GO:0008380]; tRNA pseudouridine synthesis [GO:0031119]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29628141, ECO:0000269|PubMed:35144859}.
Q96PZ2	reviewed	F111A_HUMAN	Serine protease FAM111A (EC 3.4.21.-)	FAM111A KIAA1895	Homo sapiens (Human)	611	FUNCTION: Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:32165630). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:32165630). Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors (PubMed:32165630). Required for PCNA loading on replication sites (PubMed:24561620). Promotes S-phase entry and DNA synthesis (PubMed:24561620). {ECO:0000269|PubMed:24561620, ECO:0000269|PubMed:32165630}.; FUNCTION: (Microbial infection) May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction. {ECO:0000269|PubMed:23093934}.		DNA damage response [GO:0006974]; DNA replication [GO:0006260]; negative regulation of viral genome replication [GO:0045071]; protein autoprocessing [GO:0016540]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]; replication fork processing [GO:0031297]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	peptidase activity [GO:0008233]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peptidase activity [GO:0008233]; single-stranded DNA binding [GO:0003697]; DNA damage response [GO:0006974]; DNA replication [GO:0006260]; negative regulation of viral genome replication [GO:0045071]; protein autoprocessing [GO:0016540]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]; replication fork processing [GO:0031297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23093934, ECO:0000269|PubMed:24561620}. Chromosome {ECO:0000269|PubMed:24561620}. Cytoplasm {ECO:0000269|PubMed:23093934}. Note=Mainly localizes to nucleus: colocalizes with PCNA on replication sites. {ECO:0000269|PubMed:24561620}.
Q96PZ7	reviewed	CSMD1_HUMAN	CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1)	CSMD1 KIAA1890 UNQ5952/PRO19863	Homo sapiens (Human)	3564	FUNCTION: Potential suppressor of squamous cell carcinomas.	MISCELLANEOUS: CSMD1 may be a candidate for oral and oropharyngeal squamous cell carcinomas (OSCCs). PubMed:12696061 and PubMed:14506705 are however in disagreement: while PubMed:14506705 considers CSMD1 as a strong candidate for OSCCs, PubMed:12696061 thinks it is not.	conditioned place preference [GO:1990708]; female gonad development [GO:0008585]; glucose homeostasis [GO:0042593]; male gonad development [GO:0008584]; mammary gland branching involved in pregnancy [GO:0060745]; memory [GO:0007613]; oviduct epithelium development [GO:0035846]; startle response [GO:0001964]	membrane [GO:0016020]		membrane [GO:0016020]; conditioned place preference [GO:1990708]; female gonad development [GO:0008585]; glucose homeostasis [GO:0042593]; male gonad development [GO:0008584]; mammary gland branching involved in pregnancy [GO:0060745]; memory [GO:0007613]; oviduct epithelium development [GO:0035846]; startle response [GO:0001964]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q96Q04	reviewed	LMTK3_HUMAN	Serine/threonine-protein kinase LMTK3 (EC 2.7.11.1) (Lemur tyrosine kinase 3)	LMTK3 KIAA1883 TYKLM3	Homo sapiens (Human)	1460	FUNCTION: Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity). {ECO:0000250|UniProtKB:Q5XJV6, ECO:0000269|PubMed:21602804}.		phosphorylation [GO:0016310]	axon [GO:0030424]; dendrite [GO:0030425]; Golgi membrane [GO:0000139]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	axon [GO:0030424]; dendrite [GO:0030425]; Golgi membrane [GO:0000139]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q5XJV6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q5XJV6}. Cell projection, axon {ECO:0000250|UniProtKB:Q5XJV6}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q5XJV6}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5XJV6}. Note=Punctate pattern in cell projections.
Q96Q05	reviewed	TPPC9_HUMAN	Trafficking protein particle complex subunit 9 (NIK- and IKBKB-binding protein) (Tularik gene 1 protein)	TRAPPC9 KIAA1882 NIBP T1	Homo sapiens (Human)	1148	FUNCTION: Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000269|PubMed:15951441}.		cerebral cortex development [GO:0021987]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neuron differentiation [GO:0030182]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; trans-Golgi network [GO:0005802]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; trans-Golgi network [GO:0005802]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; cerebral cortex development [GO:0021987]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neuron differentiation [GO:0030182]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Processes and cell bodies of neurons. {ECO:0000250}.
Q96Q06	reviewed	PLIN4_HUMAN	Perilipin-4 (Adipocyte protein S3-12)	PLIN4 KIAA1881	Homo sapiens (Human)	1371	FUNCTION: May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O88492}. Cytoplasm {ECO:0000250|UniProtKB:O88492}. Lipid droplet {ECO:0000250|UniProtKB:O88492}. Note=Nascent lipid droplet surface-associated; association with lipid droplets is triacylglycerol synthesis-dependent. {ECO:0000250|UniProtKB:O88492}.
Q96Q07	reviewed	BTBD9_HUMAN	BTB/POZ domain-containing protein 9	BTBD9 KIAA1880	Homo sapiens (Human)	612			adult locomotory behavior [GO:0008344]; circadian behavior [GO:0048512]; circadian sleep/wake cycle, non-REM sleep [GO:0042748]; long-term memory [GO:0007616]; modulation of chemical synaptic transmission [GO:0050804]; multicellular organismal-level iron ion homeostasis [GO:0060586]; regulation of synaptic vesicle endocytosis [GO:1900242]; sensory perception of temperature stimulus [GO:0050951]; serotonin metabolic process [GO:0042428]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]		cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; adult locomotory behavior [GO:0008344]; circadian behavior [GO:0048512]; circadian sleep/wake cycle, non-REM sleep [GO:0042748]; long-term memory [GO:0007616]; modulation of chemical synaptic transmission [GO:0050804]; multicellular organismal-level iron ion homeostasis [GO:0060586]; regulation of synaptic vesicle endocytosis [GO:1900242]; sensory perception of temperature stimulus [GO:0050951]; serotonin metabolic process [GO:0042428]	
Q96Q11	reviewed	TRNT1_HUMAN	CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase)	TRNT1 CGI-47	Homo sapiens (Human)	434	FUNCTION: Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates (PubMed:11504732, PubMed:31011209, PubMed:25193871, PubMed:25652405, PubMed:29454993, PubMed:34023389, PubMed:30959222, PubMed:25640237). tRNA 3'-terminal CCA addition is required both for tRNA processing and repair (PubMed:22076379, PubMed:25640237). Promotes tRNA repair and recycling downstream of the ribosome-associated quality control (RQC) pathway by mediating addition of the tRNA 3'-terminal CCA following cleavage by ANKZF1 and repair by ELAC1 (PubMed:31011209). Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs and tRNA-like transcripts (PubMed:22076379, PubMed:25640237). While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs beginning with GG are marked with CCACCA and rapidly degraded (PubMed:22076379, PubMed:25640237). The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA (PubMed:25640237). This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle (PubMed:25640237). {ECO:0000269|PubMed:11504732, ECO:0000269|PubMed:22076379, ECO:0000269|PubMed:25193871, ECO:0000269|PubMed:25640237, ECO:0000269|PubMed:25652405, ECO:0000269|PubMed:29454993, ECO:0000269|PubMed:30959222, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:34023389}.; FUNCTION: [Isoform 2]: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro). {ECO:0000269|PubMed:17204286}.		mitochondrial tRNA 3'-end processing [GO:1990180]; rescue of stalled ribosome [GO:0072344]; tRNA 3'-end processing [GO:0042780]; tRNA 3'-terminal CCA addition [GO:0001680]; tRNA surveillance [GO:0106354]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	5'-3' RNA polymerase activity [GO:0034062]; ATP binding [GO:0005524]; CCA tRNA nucleotidyltransferase activity [GO:0004810]; CCACCA tRNA nucleotidyltransferase activity [GO:0160016]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 5'-3' RNA polymerase activity [GO:0034062]; ATP binding [GO:0005524]; CCA tRNA nucleotidyltransferase activity [GO:0004810]; CCACCA tRNA nucleotidyltransferase activity [GO:0160016]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; mitochondrial tRNA 3'-end processing [GO:1990180]; rescue of stalled ribosome [GO:0072344]; tRNA 3'-end processing [GO:0042780]; tRNA 3'-terminal CCA addition [GO:0001680]; tRNA surveillance [GO:0106354]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11256614, ECO:0000269|PubMed:27317422, ECO:0000305|PubMed:11504732}. Cytoplasm {ECO:0000269|PubMed:27317422, ECO:0000305|PubMed:11504732}. Nucleus {ECO:0000269|PubMed:27317422}.
Q96Q15	reviewed	SMG1_HUMAN	Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1)	SMG1 ATX KIAA0421 LIP	Homo sapiens (Human)	3661	FUNCTION: Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}.	MISCELLANEOUS: This gene is located in a region of chromosome 16 that contains 2 segmental duplications. Other genes that are highly related to this exist, but they probably represent pseudogenes.	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein autophosphorylation [GO:0046777]; regulation of telomere maintenance [GO:0032204]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein autophosphorylation [GO:0046777]; regulation of telomere maintenance [GO:0032204]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15175154}. Cytoplasm {ECO:0000269|PubMed:15175154}. Note=Present in the chromatoid body. {ECO:0000250|UniProtKB:Q8BKX6}.
Q96Q27	reviewed	ASB2_HUMAN	Ankyrin repeat and SOCS box protein 2 (ASB-2)	ASB2	Homo sapiens (Human)	635	FUNCTION: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:16325183, PubMed:15590664). Mediates Notch-induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2 (PubMed:21119685). Required during embryonic heart development for complete heart looping (By similarity). Required for cardiomyocyte differentiation (PubMed:32179481). {ECO:0000250|UniProtKB:Q8K0L0, ECO:0000269|PubMed:15590664, ECO:0000269|PubMed:16325183, ECO:0000269|PubMed:21119685, ECO:0000269|PubMed:32179481}.; FUNCTION: [Isoform 1]: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA (PubMed:19300455). Also targets DES for proteasomal degradation (By similarity). Acts as a negative regulator of skeletal muscle mass (By similarity). {ECO:0000250|UniProtKB:Q8K0L0, ECO:0000269|PubMed:19300455}.; FUNCTION: [Isoform 2]: Targets filamins FLNA and FLNB for proteasomal degradation (PubMed:21737450, PubMed:22916308, PubMed:24044920, PubMed:24052262). This leads to enhanced adhesion of hematopoietic cells to fibronectin (PubMed:21737450). Required for FLNA degradation in immature cardiomyocytes which is necessary for actin cytoskeleton remodeling, leading to proper organization of myofibrils and function of mature cardiomyocytes (By similarity). Required for degradation of FLNA and FLNB in immature dendritic cells (DC) which enhances immature DC migration by promoting DC podosome formation and DC-mediated degradation of the extracellular matrix (By similarity). Does not promote proteasomal degradation of tyrosine-protein kinases JAK1 or JAK2 in hematopoietic cells (PubMed:22916308). {ECO:0000250|UniProtKB:Q8K0L0, ECO:0000269|PubMed:21737450, ECO:0000269|PubMed:22916308, ECO:0000269|PubMed:24044920, ECO:0000269|PubMed:24052262}.		actin cytoskeleton organization [GO:0030036]; cardiac muscle cell development [GO:0055013]; cardiac muscle cell differentiation [GO:0055007]; dendritic cell migration [GO:0036336]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; podosome assembly [GO:0071800]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]; skeletal muscle atrophy [GO:0014732]; skeletal muscle cell differentiation [GO:0035914]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]; Z disc [GO:0030018]	cullin family protein binding [GO:0097602]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]; Z disc [GO:0030018]; cullin family protein binding [GO:0097602]; actin cytoskeleton organization [GO:0030036]; cardiac muscle cell development [GO:0055013]; cardiac muscle cell differentiation [GO:0055007]; dendritic cell migration [GO:0036336]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; podosome assembly [GO:0071800]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]; skeletal muscle atrophy [GO:0014732]; skeletal muscle cell differentiation [GO:0035914]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:24044920}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q8K0L0}. Note=Localizes to the Z line in cardiomyocytes. {ECO:0000250|UniProtKB:Q8K0L0}.
Q96Q35	reviewed	FACC1_HUMAN	Flagellum-associated coiled-coil domain-containing protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein)	FLACC1 ALS2CR12	Homo sapiens (Human)	445				cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; outer dense fiber [GO:0001520]; sperm flagellum [GO:0036126]		cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; outer dense fiber [GO:0001520]; sperm flagellum [GO:0036126]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BVM7}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q8BVM7}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8BVM7}. Note=Expressed in the principal piece of the sperm tail, nearest the sperm head. {ECO:0000250|UniProtKB:Q8BVM7}.
Q96Q40	reviewed	CDK15_HUMAN	Cyclin-dependent kinase 15 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) (Cell division protein kinase 15) (Serine/threonine-protein kinase ALS2CR7) (Serine/threonine-protein kinase PFTAIRE-2)	CDK15 ALS2CR7 PFTK2	Homo sapiens (Human)	435	FUNCTION: Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'. {ECO:0000269|PubMed:24866247}.	MISCELLANEOUS: [Isoform 5]: May be due to competing acceptor splice site. {ECO:0000305}.	phosphorylation [GO:0016310]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	
Q96Q42	reviewed	ALS2_HUMAN	Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein)	ALS2 ALS2CR6 KIAA1563	Homo sapiens (Human)	1657	FUNCTION: May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). {ECO:0000250}.		behavioral fear response [GO:0001662]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; locomotory behavior [GO:0007626]; lysosomal transport [GO:0007041]; neuromuscular junction development [GO:0007528]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of Rac protein signal transduction [GO:0035022]; protein homooligomerization [GO:0051260]; protein localization [GO:0008104]; receptor recycling [GO:0001881]; regulation of endosome size [GO:0051036]; response to oxidative stress [GO:0006979]; synaptic transmission, glutamatergic [GO:0035249]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; vesicle [GO:0031982]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activator activity [GO:0043539]; small GTPase binding [GO:0031267]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; vesicle [GO:0031982]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activator activity [GO:0043539]; small GTPase binding [GO:0031267]; behavioral fear response [GO:0001662]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; locomotory behavior [GO:0007626]; lysosomal transport [GO:0007041]; neuromuscular junction development [GO:0007528]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of Rac protein signal transduction [GO:0035022]; protein homooligomerization [GO:0051260]; protein localization [GO:0008104]; receptor recycling [GO:0001881]; regulation of endosome size [GO:0051036]; response to oxidative stress [GO:0006979]; synaptic transmission, glutamatergic [GO:0035249]	
Q96Q45	reviewed	TM237_HUMAN	Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein)	TMEM237 ALS2CR4	Homo sapiens (Human)	408	FUNCTION: Component of the transition zone in primary cilia. Required for ciliogenesis. {ECO:0000269|PubMed:22152675}.		cilium assembly [GO:0060271]; regulation of Wnt signaling pathway [GO:0030111]	ciliary transition zone [GO:0035869]; cone photoreceptor outer segment [GO:0120199]; membrane [GO:0016020]; photoreceptor connecting cilium [GO:0032391]; rod photoreceptor outer segment [GO:0120200]		ciliary transition zone [GO:0035869]; cone photoreceptor outer segment [GO:0120199]; membrane [GO:0016020]; photoreceptor connecting cilium [GO:0032391]; rod photoreceptor outer segment [GO:0120200]; cilium assembly [GO:0060271]; regulation of Wnt signaling pathway [GO:0030111]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:22152675}. Note=Localizes at the proximal region of primary cilia were observed, consistent with localization to the transition zone. Anchored to the transition zone by RPGRIP1L.
Q96Q77	reviewed	CIB3_HUMAN	Calcium and integrin-binding family member 3 (Kinase-interacting protein 3) (KIP 3)	CIB3 KIP3	Homo sapiens (Human)	187	FUNCTION: Acts a an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells (By similarity). Plays a role in regulating hair cell MET channel localization and function (By similarity). {ECO:0000250|UniProtKB:Q0P523}.	MISCELLANEOUS: The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).	calcium ion homeostasis [GO:0055074]		calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]	calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; calcium ion homeostasis [GO:0055074]	
Q96Q80	reviewed	DERL3_HUMAN	Derlin-3 (Degradation in endoplasmic reticulum protein 3) (DERtrin-3) (Der1-like protein 3)	DERL3 C22orf14 DER3 LLN2	Homo sapiens (Human)	235	FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins (PubMed:16449189, PubMed:22607976). May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). {ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:26565908}.		endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein N-linked glycosylation via asparagine [GO:0018279]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]	misfolded protein binding [GO:0051787]; protein-containing complex binding [GO:0044877]; signal recognition particle binding [GO:0005047]; ubiquitin-specific protease binding [GO:1990381]	endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; misfolded protein binding [GO:0051787]; protein-containing complex binding [GO:0044877]; signal recognition particle binding [GO:0005047]; ubiquitin-specific protease binding [GO:1990381]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein N-linked glycosylation via asparagine [GO:0018279]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16449189}; Multi-pass membrane protein {ECO:0000269|PubMed:16449189}.
Q96Q83	reviewed	ALKB3_HUMAN	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (EC 1.14.11.33) (EC 1.14.11.54) (Alkylated DNA repair protein alkB homolog 3) (hABH3) (DEPC-1) (Prostate cancer antigen 1)	ALKBH3 ABH3 DEPC1	Homo sapiens (Human)	286	FUNCTION: Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:25944111). Has a strong preference for single-stranded DNA (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:20714506). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 (PubMed:22055184). Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA (PubMed:25797601). Also acts on RNA (PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410, PubMed:16858410). Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons (PubMed:26863196, PubMed:26863410). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:22055184, PubMed:16858410). {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:16174769, ECO:0000269|PubMed:16858410, ECO:0000269|PubMed:22055184, ECO:0000269|PubMed:25797601, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:26863196, ECO:0000269|PubMed:26863410}.		cell population proliferation [GO:0008283]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA repair [GO:0006281]; oxidative single-stranded DNA demethylation [GO:0035552]; oxidative single-stranded RNA demethylation [GO:0035553]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-N1-methyladenine dioxygenase activity [GO:0043734]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; mRNA N1-methyladenosine dioxygenase activity [GO:1990930]; oxidative DNA demethylase activity [GO:0035516]; oxidative RNA demethylase activity [GO:0035515]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-N1-methyladenine dioxygenase activity [GO:0043734]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; mRNA N1-methyladenosine dioxygenase activity [GO:1990930]; oxidative DNA demethylase activity [GO:0035516]; oxidative RNA demethylase activity [GO:0035515]; cell population proliferation [GO:0008283]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA repair [GO:0006281]; oxidative single-stranded DNA demethylation [GO:0035552]; oxidative single-stranded RNA demethylation [GO:0035553]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:29144457}. Cytoplasm {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:17979886}. Note=Colocalizes with ASCC2 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage (PubMed:29144457). Predominantly localizes to the nucleus. {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:29144457}.
Q96Q89	reviewed	KI20B_HUMAN	Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1)	KIF20B KRMP1 MPHOSPH1	Homo sapiens (Human)	1820	FUNCTION: Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}.		cell cycle [GO:0007049]; cell division [GO:0051301]; microtubule-based movement [GO:0007018]; neural tube closure [GO:0001843]; neuron projection morphogenesis [GO:0048812]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cytokinetic process [GO:1903438]; positive regulation of neuron migration [GO:2001224]; protein localization to microtubule [GO:0035372]; regulation of cell cycle [GO:0051726]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitotic nuclear division [GO:0007088]	centrosome [GO:0005813]; contractile ring [GO:0070938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle midzone [GO:0051233]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein homodimerization activity [GO:0042803]; WW domain binding [GO:0050699]	centrosome [GO:0005813]; contractile ring [GO:0070938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle midzone [GO:0051233]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein homodimerization activity [GO:0042803]; WW domain binding [GO:0050699]; cell cycle [GO:0007049]; cell division [GO:0051301]; microtubule-based movement [GO:0007018]; neural tube closure [GO:0001843]; neuron projection morphogenesis [GO:0048812]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cytokinetic process [GO:1903438]; positive regulation of neuron migration [GO:2001224]; protein localization to microtubule [GO:0035372]; regulation of cell cycle [GO:0051726]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitotic nuclear division [GO:0007088]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11470801}. Nucleus, nucleolus {ECO:0000269|PubMed:11470801}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11470801}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:11470801}. Midbody {ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. Cell projection, axon {ECO:0000250|UniProtKB:Q80WE4}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q80WE4}. Note=Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules (PubMed:12740395). Localized to the central spindle during cytokinetic furrowing and with the midbody during abscission (PubMed:12740395, PubMed:17409436). A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase (PubMed:12740395). During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone (PubMed:12740395). At anaphase it is concentrated in the midbody (PubMed:12740395). Colocalized partially along microtubules in primary neurons. Colocalized with SHTN1 along microtubules to the tip of the growing cone in primary hippocampal neurons. Localized in midbodies between dividing radial progenitors in the ventricular zone (By similarity). Colocalized with PRC1 in the nucleus of bladder carcinoma cells at the interphase. Colocalized with PRC1 in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}.
Q96Q91	reviewed	B3A4_HUMAN	Anion exchange protein 4 (AE 4) (Anion exchanger 4) (Sodium bicarbonate cotransporter 5) (Solute carrier family 4 member 9)	SLC4A9 AE4 SBC5	Homo sapiens (Human)	983	FUNCTION: Electroneutral Cl(-)/HCO3(-) antiporter that favors chloride ion entry and efflux of hydrogencarbonate and sodium ion across the basolateral membrane and may participate in salivary secretion (PubMed:27114614). Also mediates Cl(-)/HCO3(-) exchange activity in the presence of K(+) as well as Cs(+), Li(+), and Rb(+) (By similarity). Does not contribute to Cl(-)/HCO3(-) exchanger in the apical membrane of the upper villous epithelium (By similarity). {ECO:0000250|UniProtKB:A0A494BA31, ECO:0000269|PubMed:27114614}.		bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453]; saliva secretion [GO:0046541]; sodium ion transmembrane transport [GO:0035725]; transmembrane transport [GO:0055085]	apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	chloride:bicarbonate antiporter activity [GO:0140900]; sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]	apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; chloride:bicarbonate antiporter activity [GO:0140900]; sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]; bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453]; saliva secretion [GO:0046541]; sodium ion transmembrane transport [GO:0035725]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:A0A494BA31}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the basolateral membrane of the cortical collecting duct (CCD)and submandibular gland (SMG) duct. {ECO:0000250|UniProtKB:A0A494BA31}.
Q96QA5	reviewed	GSDMA_HUMAN	Gasdermin-A (Gasdermin-1) [Cleaved into: Gasdermin-A, N-terminal (GSDMA-NT); Gasdermin-A, C-terminal (GSDMA-CT)]	GSDMA GSDM GSDM1 FKSG9	Homo sapiens (Human)	445	FUNCTION: [Gasdermin-A]: This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon infection by S.pyogenes, specifically cleaved by S.pyogenes effector protein SpeB in epithelial cells, releasing the N-terminal moiety (Gasdermin-A, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. {ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:35110732, ECO:0000269|PubMed:35545676}.; FUNCTION: [Gasdermin-A, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:17471240, PubMed:27281216, PubMed:35110732, PubMed:35545676). Released upon cleavage by S.pyogenes effector protein SpeB, and binds to membrane inner leaflet lipids (PubMed:27281216, PubMed:35110732, PubMed:35545676). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:27281216, PubMed:35110732, PubMed:35545676). Pyroptosis triggers the elimination of the infected skin cell, depriving the pathogen of its protective niche, while inducing an inflammatory response (PubMed:35110732, PubMed:35545676). This ultimately prevents bacterial penetration of the epithelial barrier and a subsequent systemic dissemination of the pathogen (PubMed:35110732, PubMed:35545676). Binds to cardiolipin and other acidic phospholipids, such as phosphatidylserine, which mediate its targeting to the inner leaflet membrane (PubMed:27281216, PubMed:35110732). {ECO:0000269|PubMed:17471240, ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:35110732, ECO:0000269|PubMed:35545676}.		defense response to bacterium [GO:0042742]; pyroptosis [GO:0070269]	cytosol [GO:0005829]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; wide pore channel activity [GO:0022829]	cytosol [GO:0005829]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; wide pore channel activity [GO:0022829]; defense response to bacterium [GO:0042742]; pyroptosis [GO:0070269]	SUBCELLULAR LOCATION: [Gasdermin-A]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17471240}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5Y4Y6}.; SUBCELLULAR LOCATION: [Gasdermin-A, N-terminal]: Cell membrane {ECO:0000269|PubMed:35110732, ECO:0000269|PubMed:35545676}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
Q96QB1	reviewed	RHG07_HUMAN	Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12)	DLC1 ARHGAP7 KIAA1723 STARD12	Homo sapiens (Human)	1528	FUNCTION: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}.	MISCELLANEOUS: [Isoform 6]: Produced by alternative promoter usage. ubiquitously expressed, significantly down-regulated in multiple carcinoma cell lines. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; focal adhesion assembly [GO:0048041]; forebrain development [GO:0030900]; heart morphogenesis [GO:0003007]; hindbrain morphogenesis [GO:0021575]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	caveola [GO:0005901]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]	GTPase activator activity [GO:0005096]; lipid binding [GO:0008289]; SH2 domain binding [GO:0042169]	caveola [GO:0005901]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; GTPase activator activity [GO:0005096]; lipid binding [GO:0008289]; SH2 domain binding [GO:0042169]; actin cytoskeleton organization [GO:0030036]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; focal adhesion assembly [GO:0048041]; forebrain development [GO:0030900]; heart morphogenesis [GO:0003007]; hindbrain morphogenesis [GO:0021575]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion {ECO:0000269|PubMed:17190795}. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery.
Q96QC0	reviewed	PP1RA_HUMAN	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (Protein FB19) (p99)	PPP1R10 CAT53 FB19 PNUTS	Homo sapiens (Human)	940	FUNCTION: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity). {ECO:0000250, ECO:0000269|PubMed:9450550}.		negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of mitotic DNA damage checkpoint [GO:1904290]; positive regulation of telomere maintenance [GO:0032206]; protein import into nucleus [GO:0006606]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; RNA binding [GO:0003723]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; RNA binding [GO:0003723]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of mitotic DNA damage checkpoint [GO:1904290]; positive regulation of telomere maintenance [GO:0032206]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649, ECO:0000269|PubMed:9450550}. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). {ECO:0000250}.
Q96QD8	reviewed	S38A2_HUMAN	Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2)	SLC38A2 ATA2 KIAA1382 SAT2 SNAT2	Homo sapiens (Human)	506	FUNCTION: Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:10930503, PubMed:15922329, PubMed:16621798, PubMed:15774260). The trasnport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (PubMed:10930503, PubMed:15774260). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity). {ECO:0000250|UniProtKB:Q8CFE6, ECO:0000250|UniProtKB:Q9JHE5, ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15774260, ECO:0000269|PubMed:15922329, ECO:0000269|PubMed:16621798}.		alanine transport [GO:0032328]; amino acid import [GO:0043090]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; cellular response to amino acid starvation [GO:0034198]; cellular response to arsenite(3-) [GO:1903841]; cellular response to mechanical stimulus [GO:0071260]; cerebral cortex development [GO:0021987]; female pregnancy [GO:0007565]; glutamine transport [GO:0006868]; glycine betaine transport [GO:0031460]; L-glutamine import across plasma membrane [GO:1903803]; L-proline import across plasma membrane [GO:1904271]; L-serine import across plasma membrane [GO:1903812]; L-serine transport [GO:0015825]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; positive regulation of gene expression [GO:0010628]; positive regulation of RNA splicing [GO:0033120]; proline transport [GO:0015824]; regulation of cellular response to stress [GO:0080135]; regulation of glutamate secretion, neurotransmission [GO:1903294]; response to muscle activity [GO:0014850]; transport across blood-brain barrier [GO:0150104]	axon [GO:0030424]; brush border [GO:0005903]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	acidic amino acid transmembrane transporter activity [GO:0015172]; alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; L-glutamine transmembrane transporter activity [GO:0015186]; L-serine transmembrane transporter activity [GO:0015194]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298]	axon [GO:0030424]; brush border [GO:0005903]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; acidic amino acid transmembrane transporter activity [GO:0015172]; alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; L-glutamine transmembrane transporter activity [GO:0015186]; L-serine transmembrane transporter activity [GO:0015194]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298]; alanine transport [GO:0032328]; amino acid import [GO:0043090]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; cellular response to amino acid starvation [GO:0034198]; cellular response to arsenite(3-) [GO:1903841]; cellular response to mechanical stimulus [GO:0071260]; cerebral cortex development [GO:0021987]; female pregnancy [GO:0007565]; glutamine transport [GO:0006868]; glycine betaine transport [GO:0031460]; L-glutamine import across plasma membrane [GO:1903803]; L-proline import across plasma membrane [GO:1904271]; L-serine import across plasma membrane [GO:1903812]; L-serine transport [GO:0015825]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; positive regulation of gene expression [GO:0010628]; positive regulation of RNA splicing [GO:0033120]; proline transport [GO:0015824]; regulation of cellular response to stress [GO:0080135]; regulation of glutamate secretion, neurotransmission [GO:1903294]; response to muscle activity [GO:0014850]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9JHE5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JHE5}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250|UniProtKB:Q9JHE5}.
Q96QD9	reviewed	UIF_HUMAN	UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3)	FYTTD1 UIF	Homo sapiens (Human)	318	FUNCTION: Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269|PubMed:19836239}.		mRNA export from nucleus [GO:0006406]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:19836239}. Nucleus speckle {ECO:0000269|PubMed:19836239}.
Q96QE2	reviewed	MYCT_HUMAN	Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13)	SLC2A13	Homo sapiens (Human)	648	FUNCTION: H(+)-myo-inositol cotransporter (PubMed:11500374). Can also transport related stereoisomers (PubMed:11500374). {ECO:0000269|PubMed:11500374}.		myo-inositol transport [GO:0015798]; positive regulation of amyloid-beta formation [GO:1902004]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; cell body [GO:0044297]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]	ATPase binding [GO:0051117]; myo-inositol transmembrane transporter activity [GO:0005365]; myo-inositol:proton symporter activity [GO:0005366]; protease binding [GO:0002020]	apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; cell body [GO:0044297]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; ATPase binding [GO:0051117]; myo-inositol transmembrane transporter activity [GO:0005365]; myo-inositol:proton symporter activity [GO:0005366]; protease binding [GO:0002020]; myo-inositol transport [GO:0015798]; positive regulation of amyloid-beta formation [GO:1902004]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11500374}; Multi-pass membrane protein {ECO:0000269|PubMed:11500374}.
Q96QE3	reviewed	ATAD5_HUMAN	ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein)	ATAD5 C17orf41 Elg1 FRAG1	Homo sapiens (Human)	1844	FUNCTION: Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}.		cell population proliferation [GO:0008283]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; isotype switching [GO:0045190]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; nuclear DNA replication [GO:0033260]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; positive regulation of DNA replication [GO:0045740]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; regulation of mitotic cell cycle phase transition [GO:1901990]; signal transduction in response to DNA damage [GO:0042770]	Elg1 RFC-like complex [GO:0031391]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp unloader activity [GO:0061860]	Elg1 RFC-like complex [GO:0031391]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp unloader activity [GO:0061860]; cell population proliferation [GO:0008283]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; isotype switching [GO:0045190]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; nuclear DNA replication [GO:0033260]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; positive regulation of DNA replication [GO:0045740]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; regulation of mitotic cell cycle phase transition [GO:1901990]; signal transduction in response to DNA damage [GO:0042770]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293}. Note=Accumulates in nuclear foci at sites of stalled DNA replication forks in response to DNA damage. {ECO:0000269|PubMed:19755857}.
Q96QE5	reviewed	TEFM_HUMAN	Transcription elongation factor, mitochondrial	TEFM C17orf42	Homo sapiens (Human)	360	FUNCTION: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery. {ECO:0000269|PubMed:21278163}.		mitochondrial transcription [GO:0006390]; oxidative phosphorylation [GO:0006119]; transcription elongation by mitochondrial RNA polymerase [GO:0006392]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]	DNA polymerase processivity factor activity [GO:0030337]; RNA binding [GO:0003723]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; DNA polymerase processivity factor activity [GO:0030337]; RNA binding [GO:0003723]; mitochondrial transcription [GO:0006390]; oxidative phosphorylation [GO:0006119]; transcription elongation by mitochondrial RNA polymerase [GO:0006392]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:21278163}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:21278163}.
Q96QF0	reviewed	RAB3I_HUMAN	Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (Rabin8) (SSX2-interacting protein)	RAB3IP RABIN8	Homo sapiens (Human)	476	FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:31204173, PubMed:25673879). {ECO:0000269|PubMed:12221131, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:31204173}.		ciliary basal body-plasma membrane docking [GO:0097711]; cilium assembly [GO:0060271]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; negative regulation of filopodium assembly [GO:0051490]; protein localization to organelle [GO:0033365]; protein targeting to membrane [GO:0006612]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; Golgi to plasma membrane transport vesicle [GO:0070319]; lamellipodium [GO:0030027]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proximal dendrite [GO:1990635]	GTPase binding [GO:0051020]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; Golgi to plasma membrane transport vesicle [GO:0070319]; lamellipodium [GO:0030027]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proximal dendrite [GO:1990635]; GTPase binding [GO:0051020]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; ciliary basal body-plasma membrane docking [GO:0097711]; cilium assembly [GO:0060271]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; negative regulation of filopodium assembly [GO:0051490]; protein localization to organelle [GO:0033365]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12007189, ECO:0000269|PubMed:31467083}. Nucleus {ECO:0000269|PubMed:12007189}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12221131}. Cell projection, lamellipodium. Vesicle {ECO:0000269|PubMed:31467083}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:31467083}. Note=Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. {ECO:0000269|PubMed:12007189}.
Q96QF7	reviewed	GCNA_HUMAN	Germ cell nuclear acidic protein (Acidic repeat-containing protein) (Germ cell nuclear acidic peptidase) (Germ cell nuclear antigen)	GCNA ACRC	Homo sapiens (Human)	691	FUNCTION: May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage (PubMed:30914427). Can resolve the topoisomerase II (TOP2A) DPCs (By similarity). {ECO:0000250|UniProtKB:A0A1D9BZF0, ECO:0000269|PubMed:30914427}.		protein-DNA covalent cross-linking repair [GO:0106300]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	SUMO polymer binding [GO:0032184]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; SUMO polymer binding [GO:0032184]; protein-DNA covalent cross-linking repair [GO:0106300]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27718356, ECO:0000305|PubMed:11714101}. Nucleus, PML body {ECO:0000269|PubMed:30914427}. Chromosome {ECO:0000250|UniProtKB:A0A1D9BZF0}. Note=Co-localizes with SUMO2 at PML bodies in all interphase cells (PubMed:30914427). Localizes on condensed chromosomes in spermatocytes in G2 and M during meiotic prophase (By similarity). {ECO:0000250|UniProtKB:A0A1D9BZF0, ECO:0000269|PubMed:30914427}.
Q96QG7	reviewed	MTMR9_HUMAN	Myotubularin-related protein 9 (Inactive phosphatidylinositol 3-phosphatase 9)	MTMR9 C8orf9 MTMR8	Homo sapiens (Human)	549	FUNCTION: Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598). Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598). Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate (PubMed:22647598). The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). Stabilizes MTMR8 protein levels (PubMed:22647598). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598). Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598). Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970). {ECO:0000250|UniProtKB:Q9Z2D0, ECO:0000269|PubMed:19038970, ECO:0000269|PubMed:22647598, ECO:0000269|PubMed:24591580}.		endocytosis [GO:0006897]; negative regulation of autophagy [GO:0010507]; positive regulation of phosphatase activity [GO:0010922]; protein stabilization [GO:0050821]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]	enzyme regulator activity [GO:0030234]; protein phosphatase binding [GO:0019903]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; enzyme regulator activity [GO:0030234]; protein phosphatase binding [GO:0019903]; endocytosis [GO:0006897]; negative regulation of autophagy [GO:0010507]; positive regulation of phosphatase activity [GO:0010922]; protein stabilization [GO:0050821]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:19038970}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9Z2D0}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:19038970}. Endoplasmic reticulum {ECO:0000269|PubMed:19038970}. Note=Localizes to ruffles during EGF-induced macropinocytosis (By similarity). Colocalizes with MTMR6 to the perinuclear region (PubMed:19038970). Partially localizes to the endoplasmic reticulum (PubMed:19038970). {ECO:0000250|UniProtKB:Q9Z2D0, ECO:0000269|PubMed:19038970}.
Q96QH2	reviewed	PRAM_HUMAN	PML-RARA-regulated adapter molecule 1 (PRAM) (PRAM-1)	PRAM1	Homo sapiens (Human)	670	FUNCTION: May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.		integrin-mediated signaling pathway [GO:0007229]; protein localization to plasma membrane [GO:0072659]; regulation of neutrophil degranulation [GO:0043313]; T cell receptor signaling pathway [GO:0050852]	plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	lipid binding [GO:0008289]; protein kinase binding [GO:0019901]	plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]; integrin-mediated signaling pathway [GO:0007229]; protein localization to plasma membrane [GO:0072659]; regulation of neutrophil degranulation [GO:0043313]; T cell receptor signaling pathway [GO:0050852]	
Q96QI5	reviewed	HS3S6_HUMAN	Heparan sulfate glucosamine 3-O-sulfotransferase 6 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6) (3-OST-6) (Heparan sulfate 3-O-sulfotransferase 6) (h3-OST-6)	HS3ST6 HS3ST5	Homo sapiens (Human)	342	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. {ECO:0000269|PubMed:15303968}.		blastocyst hatching [GO:0001835]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	Golgi membrane [GO:0000139]	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]	Golgi membrane [GO:0000139]; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; blastocyst hatching [GO:0001835]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q96QK1	reviewed	VPS35_HUMAN	Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35)	VPS35 MEM3 TCCCTA00141	Homo sapiens (Human)	796	FUNCTION: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:30213940). The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227, PubMed:28892079). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24980502, PubMed:24819384). Required for the endosomal localization of TBC1D5 (PubMed:20923837). {ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:20164305, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24819384, ECO:0000269|PubMed:24980502, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:30213940, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:22070227, ECO:0000303|PubMed:22513087, ECO:0000303|PubMed:23563491}.; FUNCTION: (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus. {ECO:0000269|PubMed:25693203, ECO:0000269|PubMed:30122350}.		endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrion to lysosome transport [GO:0099074]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of lysosomal protein catabolic process [GO:1905166]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of protein localization [GO:1903828]; neurotransmitter receptor transport, endosome to plasma membrane [GO:0099639]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine biosynthetic process [GO:1903181]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of gene expression [GO:0010628]; positive regulation of locomotion involved in locomotory behavior [GO:0090326]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of Wnt protein secretion [GO:0061357]; protein destabilization [GO:0031648]; protein localization to endosome [GO:0036010]; regulation of dendritic spine maintenance [GO:1902950]; regulation of macroautophagy [GO:0016241]; regulation of mitochondrion organization [GO:0010821]; regulation of postsynapse assembly [GO:0150052]; regulation of presynapse assembly [GO:1905606]; regulation of protein metabolic process [GO:0051246]; regulation of protein stability [GO:0031647]; regulation of synapse maturation [GO:0090128]; regulation of terminal button organization [GO:2000331]; retrograde transport, endosome to Golgi [GO:0042147]; transcytosis [GO:0045056]; vesicle-mediated transport in synapse [GO:0099003]; voluntary musculoskeletal movement [GO:0050882]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrion-derived vesicle [GO:0099073]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422]	D1 dopamine receptor binding [GO:0031748]	cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrion-derived vesicle [GO:0099073]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422]; D1 dopamine receptor binding [GO:0031748]; endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrion to lysosome transport [GO:0099074]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of lysosomal protein catabolic process [GO:1905166]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of protein localization [GO:1903828]; neurotransmitter receptor transport, endosome to plasma membrane [GO:0099639]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine biosynthetic process [GO:1903181]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of gene expression [GO:0010628]; positive regulation of locomotion involved in locomotory behavior [GO:0090326]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of Wnt protein secretion [GO:0061357]; protein destabilization [GO:0031648]; protein localization to endosome [GO:0036010]; regulation of dendritic spine maintenance [GO:1902950]; regulation of macroautophagy [GO:0016241]; regulation of mitochondrion organization [GO:0010821]; regulation of postsynapse assembly [GO:0150052]; regulation of presynapse assembly [GO:1905606]; regulation of protein metabolic process [GO:0051246]; regulation of protein stability [GO:0031647]; regulation of synapse maturation [GO:0090128]; regulation of terminal button organization [GO:2000331]; retrograde transport, endosome to Golgi [GO:0042147]; transcytosis [GO:0045056]; vesicle-mediated transport in synapse [GO:0099003]; voluntary musculoskeletal movement [GO:0050882]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Endosome {ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:28892079}. Early endosome {ECO:0000305}. Late endosome {ECO:0000305}. Note=Localizes to tubular profiles adjacent to endosomes. {ECO:0000269|PubMed:15078903}.
Q96QP1	reviewed	ALPK1_HUMAN	Alpha-protein kinase 1 (EC 2.7.11.1) (Chromosome 4 kinase) (Lymphocyte alpha-protein kinase)	ALPK1 KIAA1527 LAK	Homo sapiens (Human)	1244	FUNCTION: Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling (PubMed:30111836). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161). May play a role in ciliogenesis (PubMed:30967659). {ECO:0000269|PubMed:15883161, ECO:0000269|PubMed:27169898, ECO:0000269|PubMed:28222186, ECO:0000269|PubMed:28877472, ECO:0000269|PubMed:30111836, ECO:0000269|PubMed:30967659}.		cilium assembly [GO:0060271]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; innate immune response [GO:0045087]; phosphorylation [GO:0016310]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; monosaccharide binding [GO:0048029]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; monosaccharide binding [GO:0048029]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cilium assembly [GO:0060271]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; innate immune response [GO:0045087]; phosphorylation [GO:0016310]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:30111836}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:30967659}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30967659}. Cell projection, cilium {ECO:0000269|PubMed:30967659}. Note=Localized at the base of primary cilia. {ECO:0000269|PubMed:30967659}.
Q96QR8	reviewed	PURB_HUMAN	Transcriptional activator protein Pur-beta (Purine-rich element-binding protein B)	PURB	Homo sapiens (Human)	312	FUNCTION: Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). {ECO:0000250, ECO:0000269|PubMed:1448097}.	MISCELLANEOUS: Defects in PURB may be a cause of progression of myelodysplastic syndrome (MDS) towards acute myelogenous leukemia (AML). MDS refers to a heterogeneous group of closely related hematopoietic disorders. All are characterized by a cellular marrow with impaired morphology and maturation (dysmyelopoiesis) and peripheral blood cytopenias, resulting from ineffective blood cell production. Some patients with MDS develop acute myelogenous leukemia (AML), a malignant disease in which hematopoietic precursors are arrested in an early stage of development.	regulation of myeloid cell differentiation [GO:0045637]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; mRNA binding [GO:0003729]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; single-stranded DNA binding [GO:0003697]; SMAD binding [GO:0046332]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; mRNA binding [GO:0003729]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; single-stranded DNA binding [GO:0003697]; SMAD binding [GO:0046332]; regulation of myeloid cell differentiation [GO:0045637]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1448097}.
Q96QS3	reviewed	ARX_HUMAN	Homeobox protein ARX (Aristaless-related homeobox)	ARX	Homo sapiens (Human)	562	FUNCTION: Transcription factor (PubMed:22194193, PubMed:31691806). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (PubMed:22194193, PubMed:31691806). Positively modulates transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (PubMed:31691806). Required for normal brain development (PubMed:11889467, PubMed:12379852, PubMed:14722918). Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity). {ECO:0000250|UniProtKB:O35085, ECO:0000269|PubMed:11889467, ECO:0000269|PubMed:12379852, ECO:0000269|PubMed:14722918, ECO:0000269|PubMed:22194193, ECO:0000269|PubMed:31691806}.		axon guidance [GO:0007411]; cell proliferation in forebrain [GO:0021846]; cerebral cortex GABAergic interneuron migration [GO:0021853]; cerebral cortex tangential migration [GO:0021800]; embryonic olfactory bulb interneuron precursor migration [GO:0021831]; epithelial cell fate commitment [GO:0072148]; globus pallidus development [GO:0021759]; lipid digestion [GO:0044241]; negative regulation of transcription by RNA polymerase II [GO:0000122]; organ growth [GO:0035265]; positive regulation of gene expression [GO:0010628]; positive regulation of organ growth [GO:0046622]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epithelial cell proliferation [GO:0050678]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; axon guidance [GO:0007411]; cell proliferation in forebrain [GO:0021846]; cerebral cortex GABAergic interneuron migration [GO:0021853]; cerebral cortex tangential migration [GO:0021800]; embryonic olfactory bulb interneuron precursor migration [GO:0021831]; epithelial cell fate commitment [GO:0072148]; globus pallidus development [GO:0021759]; lipid digestion [GO:0044241]; negative regulation of transcription by RNA polymerase II [GO:0000122]; organ growth [GO:0035265]; positive regulation of gene expression [GO:0010628]; positive regulation of organ growth [GO:0046622]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epithelial cell proliferation [GO:0050678]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Q96QS6	reviewed	PSKH2_HUMAN	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (Protein serine kinase H2) (PSK-H2)	PSKH2	Homo sapiens (Human)	385			phosphorylation [GO:0016310]		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	
Q96QT4	reviewed	TRPM7_HUMAN	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7)	TRPM7 CHAK1 LTRPC7	Homo sapiens (Human)	1865	FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium (PubMed:35561741). Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). {ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741}.		actomyosin structure organization [GO:0031032]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-dependent cell-matrix adhesion [GO:0016340]; monoatomic cation transmembrane transport [GO:0098655]; necroptotic process [GO:0070266]; phosphorylation [GO:0016310]; protein tetramerization [GO:0051262]	plasma membrane [GO:0005886]; ruffle [GO:0001726]	actin binding [GO:0003779]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	plasma membrane [GO:0005886]; ruffle [GO:0001726]; actin binding [GO:0003779]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; actomyosin structure organization [GO:0031032]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-dependent cell-matrix adhesion [GO:0016340]; monoatomic cation transmembrane transport [GO:0098655]; necroptotic process [GO:0070266]; phosphorylation [GO:0016310]; protein tetramerization [GO:0051262]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96QT6	reviewed	PHF12_HUMAN	PHD finger protein 12 (PHD factor 1) (Pf1)	PHF12 KIAA1523	Homo sapiens (Human)	1004	FUNCTION: Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA. {ECO:0000269|PubMed:11390640, ECO:0000303|PubMed:11390640}.	MISCELLANEOUS: [Isoform 3]: Incomplete sequence. {ECO:0000305}.	negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; Sin3-type complex [GO:0070822]; transcription repressor complex [GO:0017053]	metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; Sin3-type complex [GO:0070822]; transcription repressor complex [GO:0017053]; metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11390640}.
Q96QU1	reviewed	PCD15_HUMAN	Protocadherin-15	PCDH15 USH1F	Homo sapiens (Human)	1955	FUNCTION: Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.		cell adhesion [GO:0007155]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; synapse [GO:0045202]	calcium ion binding [GO:0005509]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Efficient localization to the plasma membrane requires the presence of LHFPL5. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Q96QU8	reviewed	XPO6_HUMAN	Exportin-6 (Exp6) (Ran-binding protein 20)	XPO6 KIAA0370 RANBP20	Homo sapiens (Human)	1125	FUNCTION: Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. {ECO:0000269|PubMed:14592989}.		protein export from nucleus [GO:0006611]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267]; protein export from nucleus [GO:0006611]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14592989}. Cytoplasm {ECO:0000269|PubMed:14592989}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:14592989}.
Q96QV1	reviewed	HHIP_HUMAN	Hedgehog-interacting protein (HHIP) (HIP)	HHIP HIP UNQ5825/PRO19644	Homo sapiens (Human)	700	FUNCTION: Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. {ECO:0000269|PubMed:11472839, ECO:0000269|PubMed:19561609}.	MISCELLANEOUS: [Isoform 2]: Potentially soluble form. {ECO:0000305}.	dorsal/ventral pattern formation [GO:0009953]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; negative regulation of apoptotic process [GO:0043066]; negative regulation of signal transduction [GO:0009968]; negative regulation of smoothened signaling pathway [GO:0045879]; neuroblast proliferation [GO:0007405]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; signal transduction [GO:0007165]; skeletal system morphogenesis [GO:0048705]	cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	hedgehog family protein binding [GO:0097108]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; hedgehog family protein binding [GO:0097108]; zinc ion binding [GO:0008270]; dorsal/ventral pattern formation [GO:0009953]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; negative regulation of apoptotic process [GO:0043066]; negative regulation of signal transduction [GO:0009968]; negative regulation of smoothened signaling pathway [GO:0045879]; neuroblast proliferation [GO:0007405]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; signal transduction [GO:0007165]; skeletal system morphogenesis [GO:0048705]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=The last 22 C-terminal amino acids may participate in cell membrane attachment.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.
Q96QV6	reviewed	H2A1A_HUMAN	Histone H2A type 1-A (H2A-clustered histone 1) (Histone H2A/r)	H2AC1 H2AFR HIST1H2AA	Homo sapiens (Human)	131	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		chromatin organization [GO:0006325]	chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; female germ cell nucleus [GO:0001674]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; female germ cell nucleus [GO:0001674]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; chromatin organization [GO:0006325]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q96QZ7	reviewed	MAGI1_HUMAN	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3)	MAGI1 AIP3 BAIAP1 BAP1 TNRC19	Homo sapiens (Human)	1491	FUNCTION: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of cell-cell adhesion [GO:0022409]; protein-containing complex assembly [GO:0065003]; signal transduction [GO:0007165]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	alpha-actinin binding [GO:0051393]; ATP binding [GO:0005524]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; alpha-actinin binding [GO:0051393]; ATP binding [GO:0005524]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of cell-cell adhesion [GO:0022409]; protein-containing complex assembly [GO:0065003]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:11969287}. Cell membrane {ECO:0000269|PubMed:11969287}; Peripheral membrane protein {ECO:0000269|PubMed:11969287}. Note=Localizes to epithelial cells tight junctions.
Q96R06	reviewed	SPAG5_HUMAN	Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)	SPAG5	Homo sapiens (Human)	1193	FUNCTION: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}.		cell division [GO:0051301]; chromosome segregation [GO:0007059]; establishment of spindle orientation [GO:0051294]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of intracellular transport [GO:0032388]; positive regulation of spindle assembly [GO:1905832]; protein localization to centrosome [GO:0071539]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of metaphase plate congression [GO:0090235]; spindle organization [GO:0007051]	centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule plus-end [GO:0035371]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]	microtubule binding [GO:0008017]	centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule plus-end [GO:0035371]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; microtubule binding [GO:0008017]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; establishment of spindle orientation [GO:0051294]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of intracellular transport [GO:0032388]; positive regulation of spindle assembly [GO:1905832]; protein localization to centrosome [GO:0071539]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of metaphase plate congression [GO:0090235]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27462074}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:27462074}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:27462074}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:27462074}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:27462074}. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26297806}. Note=Colocalizes with PCM1 at centriolar satellites throughout the cell cycle (PubMed:26297806). In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase (PubMed:27462074). Efficient targeting to the mitotic spindle may depend upon phosphorylation by GSK3B. Detected on kinetochores of chromosomes that have congressed. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (By similarity). In non-mitotic non-stressed cells, shows a microtubuli pattern. In arsenite-stressed cells, accumulates in stress granules. {ECO:0000250, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074}.
Q96RD7	reviewed	PANX1_HUMAN	Pannexin-1	PANX1 MRS1 UNQ2529/PRO6028	Homo sapiens (Human)	426	FUNCTION: Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). Plays a critical role in oogenesis (PubMed:30918116). {ECO:0000269|PubMed:16908669, ECO:0000269|PubMed:20829356, ECO:0000269|PubMed:30918116}.		calcium ion transport [GO:0006816]; cell-cell signaling [GO:0007267]; monoatomic cation transport [GO:0006812]; oogenesis [GO:0048477]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage cytokine production [GO:0060907]; response to ATP [GO:0033198]; response to ischemia [GO:0002931]	bleb [GO:0032059]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gap junction [GO:0005921]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	actin filament binding [GO:0051015]; calcium channel activity [GO:0005262]; gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802]; leak channel activity [GO:0022840]; protease binding [GO:0002020]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325]; wide pore channel activity [GO:0022829]	bleb [GO:0032059]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gap junction [GO:0005921]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; actin filament binding [GO:0051015]; calcium channel activity [GO:0005262]; gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802]; leak channel activity [GO:0022840]; protease binding [GO:0002020]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325]; wide pore channel activity [GO:0022829]; calcium ion transport [GO:0006816]; cell-cell signaling [GO:0007267]; monoatomic cation transport [GO:0006812]; oogenesis [GO:0048477]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage cytokine production [GO:0060907]; response to ATP [GO:0033198]; response to ischemia [GO:0002931]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30918116}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap junction {ECO:0000269|PubMed:16908669, ECO:0000269|PubMed:17715132}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}.
Q96RD9	reviewed	FCRL5_HUMAN	Fc receptor-like protein 5 (FcR-like protein 5) (FcRL5) (BXMAS1) (Fc receptor homolog 5) (FcRH5) (Immune receptor translocation-associated protein 2) (CD antigen CD307e)	FCRL5 FCRH5 IRTA2 UNQ503/PRO820	Homo sapiens (Human)	977	FUNCTION: May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (By similarity). {ECO:0000250|UniProtKB:Q68SN8, ECO:0000269|PubMed:11453668}.		cell surface receptor signaling pathway [GO:0007166]; single fertilization [GO:0007338]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}.
Q96RE7	reviewed	NACC1_HUMAN	Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B)	NACC1 BTBD14B NAC1	Homo sapiens (Human)	527	FUNCTION: Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17804717}.		negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; regulation of transcription by RNA polymerase II [GO:0006357]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation. {ECO:0000250}.
Q96RE9	reviewed	ZN300_HUMAN	Zinc finger protein 300	ZNF300	Homo sapiens (Human)	604	FUNCTION: Has a transcriptional repressor activity. {ECO:0000269|PubMed:14746915}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14746915, ECO:0000269|PubMed:23665872}.
Q96RF0	reviewed	SNX18_HUMAN	Sorting nexin-18 (SH3 and PX domain-containing protein 3B)	SNX18 SH3PXD3B	Homo sapiens (Human)	628	FUNCTION: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis (PubMed:20427313, PubMed:18411244, PubMed:21048941, PubMed:22718350). Required for efficient progress through mitosis and cytokinesis (PubMed:22718350). Required for normal formation of the cleavage furrow at the end of mitosis (PubMed:22718350). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis (PubMed:20427313). Plays a role in macropinocytosis (PubMed:21048941). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation (PubMed:18411244). Stimulates the GTPase activity of DNM2 (PubMed:20427313). Promotes DNM2 location at the plasma membrane (PubMed:20427313). Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A (PubMed:29437695). {ECO:0000269|PubMed:18411244, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350, ECO:0000269|PubMed:29437695}.		cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; mitotic cytokinesis [GO:0000281]; plasma membrane tubulation [GO:0097320]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of GTPase activity [GO:0043547]; protein transport [GO:0015031]; selective autophagy [GO:0061912]	cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; mitotic cytokinesis [GO:0000281]; plasma membrane tubulation [GO:0097320]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of GTPase activity [GO:0043547]; protein transport [GO:0015031]; selective autophagy [GO:0061912]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:22718350}; Peripheral membrane protein {ECO:0000269|PubMed:18411244}; Cytoplasmic side {ECO:0000269|PubMed:18411244}. Endosome membrane {ECO:0000269|PubMed:29437695}; Peripheral membrane protein {ECO:0000269|PubMed:18411244}; Cytoplasmic side {ECO:0000269|PubMed:18411244}. Recycling endosome membrane {ECO:0000269|PubMed:29437695}; Peripheral membrane protein {ECO:0000269|PubMed:18411244}; Cytoplasmic side {ECO:0000269|PubMed:18411244}. Cell membrane {ECO:0000269|PubMed:20427313}; Peripheral membrane protein {ECO:0000269|PubMed:18411244}; Cytoplasmic side {ECO:0000269|PubMed:18411244}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18411244}; Peripheral membrane protein {ECO:0000269|PubMed:18411244}; Cytoplasmic side {ECO:0000269|PubMed:18411244}. Note=Localized at sites of endocytosis at the cell membrane (PubMed:18411244). Detected on newly formed macropinosomes (PubMed:21048941). Partially colocalized with clathrin and dynamin at the cell membrane (PubMed:20427313). Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation (PubMed:18411244). {ECO:0000269|PubMed:18411244, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941}.
Q96RG2	reviewed	PASK_HUMAN	PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1)	PASK KIAA0135	Homo sapiens (Human)	1323	FUNCTION: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}.		energy homeostasis [GO:0097009]; intracellular signal transduction [GO:0035556]; negative regulation of glycogen biosynthetic process [GO:0045719]; positive regulation of translation [GO:0045727]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of glucagon secretion [GO:0070092]; regulation of respiratory gaseous exchange [GO:0043576]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; energy homeostasis [GO:0097009]; intracellular signal transduction [GO:0035556]; negative regulation of glycogen biosynthetic process [GO:0045719]; positive regulation of translation [GO:0045727]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of glucagon secretion [GO:0070092]; regulation of respiratory gaseous exchange [GO:0043576]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17595531}. Nucleus {ECO:0000269|PubMed:17595531}. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.
Q96RI0	reviewed	PAR4_HUMAN	Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)	F2RL3 PAR4	Homo sapiens (Human)	385	FUNCTION: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). May play a role in platelets activation (PubMed:10079109). {ECO:0000269|PubMed:10079109}.		blood coagulation [GO:0007596]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet dense granule organization [GO:0060155]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of Rho protein signal transduction [GO:0035025]; response to wounding [GO:0009611]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; protease binding [GO:0002020]; thrombin-activated receptor activity [GO:0015057]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; protease binding [GO:0002020]; thrombin-activated receptor activity [GO:0015057]; blood coagulation [GO:0007596]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet dense granule organization [GO:0060155]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of Rho protein signal transduction [GO:0035025]; response to wounding [GO:0009611]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RI1	reviewed	NR1H4_HUMAN	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)	NR1H4 BAR FXR HRR1 RIP14	Homo sapiens (Human)	486	FUNCTION: Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response (PubMed:10334992, PubMed:10334993, PubMed:21383957, PubMed:22820415). The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity (By similarity). In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). Activates transcription of the repressor MAFG (involved in regulation of BA synthesis) (By similarity). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) (PubMed:12754200, PubMed:15471871, PubMed:17895379). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) (PubMed:10514450, PubMed:15239098, PubMed:16269519). In the intestine activates FGF19 expression and secretion leading to hepatic CYP7A1 repression (PubMed:12815072, PubMed:19085950). The function also involves the coordinated induction of hepatic KLB/beta-klotho expression (By similarity). Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA (PubMed:12806625, PubMed:16946559). Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, PPARA (involved in beta-oxidation of fatty acids), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly (PubMed:12660231, PubMed:12554753, PubMed:15337761). Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance) (PubMed:11579204). Transrepresses APOA1 involving a monomeric competition with NR2A1 for binding to a DR1 element (PubMed:11927623, PubMed:21804189). Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase) (PubMed:12891557). Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes. Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3) (By similarity). Modulates glucose-stimulated insulin secretion and is involved in insulin resistance (PubMed:20447400). Involved in intestinal innate immunity. Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier (By similarity). Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells (PubMed:21242261). Mediates trans-repression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2 (PubMed:19864602). Involved in the TLR9-mediated protective mechanism in intestinal inflammation. Plays an anti-inflammatory role in liver inflammation; proposed to inhibit pro-inflammatory (but not antiapoptotic) NF-kappa-B signaling) (By similarity). {ECO:0000250|UniProtKB:Q60641, ECO:0000250|UniProtKB:Q62735, ECO:0000269|PubMed:10334992, ECO:0000269|PubMed:10334993, ECO:0000269|PubMed:10514450, ECO:0000269|PubMed:11579204, ECO:0000269|PubMed:11927623, ECO:0000269|PubMed:12554753, ECO:0000269|PubMed:12660231, ECO:0000269|PubMed:12718892, ECO:0000269|PubMed:12754200, ECO:0000269|PubMed:12806625, ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:12891557, ECO:0000269|PubMed:14684751, ECO:0000269|PubMed:15239098, ECO:0000269|PubMed:15337761, ECO:0000269|PubMed:15471871, ECO:0000269|PubMed:16269519, ECO:0000269|PubMed:16946559, ECO:0000269|PubMed:17895379, ECO:0000269|PubMed:18621523, ECO:0000269|PubMed:19085950, ECO:0000269|PubMed:19410460, ECO:0000269|PubMed:19586769, ECO:0000269|PubMed:19864602, ECO:0000269|PubMed:20447400, ECO:0000269|PubMed:21242261, ECO:0000269|PubMed:21804189, ECO:0000269|PubMed:23928191, ECO:0000305|PubMed:21383957, ECO:0000305|PubMed:22820415}.; FUNCTION: [Isoform 1]: Promotes transcriptional activation of target genes NR0B2/SHP (inducible by unconjugated CDCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; low activity for ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA); not inducible by taurine- and glycine-amidated CDCA. {ECO:0000269|PubMed:23928191}.; FUNCTION: [Isoform 2]: Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA), NR0B2/SHP (inducible by unconjugated CDCA DCA and ACA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; not inducible by taurine- and glycine-amidated CDCA. {ECO:0000269|PubMed:23928191}.; FUNCTION: [Isoform 3]: Promotes transcriptional activation of target genes NR0B2/SHP (inducible by unconjugated CDCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and IBAP; low activity for ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA); not inducible by taurine- and glycine-amidated CDCA. {ECO:0000269|PubMed:23928191}.; FUNCTION: [Isoform 4]: Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA. {ECO:0000269|PubMed:23928191, ECO:0000269|PubMed:26888176}.	MISCELLANEOUS: Ursodeoxycholic acid (UDCA), a natural agonist of FXR, is approved to treat primary biliary cirrhosis. However, effects are discussed controversial. UDCA is also used to dissolve (cholesterol) gallstones as alternative to surgery. {ECO:0000305|PubMed:23235576}.; MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 3. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing of isoform 3. {ECO:0000305}.	bile acid metabolic process [GO:0008206]; bile acid signaling pathway [GO:0038183]; cell differentiation [GO:0030154]; cell-cell junction assembly [GO:0007043]; cellular response to bile acid [GO:1903413]; cellular response to fatty acid [GO:0071398]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to organonitrogen compound [GO:0071417]; cholesterol homeostasis [GO:0042632]; defense response to bacterium [GO:0042742]; fatty acid homeostasis [GO:0055089]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular bile acid receptor signaling pathway [GO:0038185]; intracellular glucose homeostasis [GO:0001678]; intracellular receptor signaling pathway [GO:0030522]; intracellular triglyceride homeostasis [GO:0035356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type II interferon production [GO:0032689]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; nitrogen catabolite activation of transcription from RNA polymerase II promoter [GO:0001080]; Notch signaling pathway [GO:0007219]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of ammonia assimilation cycle [GO:2001250]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glutamate metabolic process [GO:2000213]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of phosphatidic acid biosynthetic process [GO:1905695]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of cholesterol metabolic process [GO:0090181]; regulation of DNA-templated transcription [GO:0006355]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of low-density lipoprotein particle clearance [GO:0010988]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of urea metabolic process [GO:0034255]; toll-like receptor 9 signaling pathway [GO:0034162]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; receptor complex [GO:0043235]	bile acid binding [GO:0032052]; bile acid receptor activity [GO:0038181]; chenodeoxycholic acid binding [GO:1902122]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear receptor binding [GO:0016922]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; receptor complex [GO:0043235]; bile acid binding [GO:0032052]; bile acid receptor activity [GO:0038181]; chenodeoxycholic acid binding [GO:1902122]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear receptor binding [GO:0016922]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]; bile acid metabolic process [GO:0008206]; bile acid signaling pathway [GO:0038183]; cell differentiation [GO:0030154]; cell-cell junction assembly [GO:0007043]; cellular response to bile acid [GO:1903413]; cellular response to fatty acid [GO:0071398]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to organonitrogen compound [GO:0071417]; cholesterol homeostasis [GO:0042632]; defense response to bacterium [GO:0042742]; fatty acid homeostasis [GO:0055089]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular bile acid receptor signaling pathway [GO:0038185]; intracellular glucose homeostasis [GO:0001678]; intracellular receptor signaling pathway [GO:0030522]; intracellular triglyceride homeostasis [GO:0035356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type II interferon production [GO:0032689]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; nitrogen catabolite activation of transcription from RNA polymerase II promoter [GO:0001080]; Notch signaling pathway [GO:0007219]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of ammonia assimilation cycle [GO:2001250]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glutamate metabolic process [GO:2000213]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of phosphatidic acid biosynthetic process [GO:1905695]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of cholesterol metabolic process [GO:0090181]; regulation of DNA-templated transcription [GO:0006355]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of low-density lipoprotein particle clearance [GO:0010988]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of urea metabolic process [GO:0034255]; toll-like receptor 9 signaling pathway [GO:0034162]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19864602}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:23928191}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:23928191}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:23928191}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000269|PubMed:23928191}.
Q96RI8	reviewed	TAAR6_HUMAN	Trace amine-associated receptor 6 (TaR-6) (Trace amine receptor 6) (Trace amine receptor 4) (TaR-4)	TAAR6 TA4 TAR4 TRAR4	Homo sapiens (Human)	345	FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RJ3	reviewed	TR13C_HUMAN	Tumor necrosis factor receptor superfamily member 13C (B-cell-activating factor receptor) (BAFF receptor) (BAFF-R) (BLyS receptor 3) (CD antigen CD268)	TNFRSF13C BAFFR BR3	Homo sapiens (Human)	184	FUNCTION: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:11591325, ECO:0000269|PubMed:12387744}.		adaptive immune response [GO:0002250]; B cell costimulation [GO:0031296]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of T cell proliferation [GO:0042102]; T cell costimulation [GO:0031295]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; adaptive immune response [GO:0002250]; B cell costimulation [GO:0031296]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of T cell proliferation [GO:0042102]; T cell costimulation [GO:0031295]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Q96RJ6	reviewed	FER3L_HUMAN	Fer3-like protein (Basic helix-loop-helix protein N-twist) (Class A basic helix-loop-helix protein 31) (bHLHa31) (Nephew of atonal 3) (Neuronal twist)	FERD3L BHLHA31 NATO3 NTWIST	Homo sapiens (Human)	166	FUNCTION: Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity). {ECO:0000250}.		cell development [GO:0048468]; developmental process [GO:0032502]; floor plate development [GO:0033504]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; cell development [GO:0048468]; developmental process [GO:0032502]; floor plate development [GO:0033504]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q96RK0	reviewed	CIC_HUMAN	Protein capicua homolog	CIC KIAA0306	Homo sapiens (Human)	1608	FUNCTION: Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. {ECO:0000250|UniProtKB:Q924A2}.	MISCELLANEOUS: Expressed in medulloblastoma, a pediatric brain tumor which may arise from the granule cell lineage.	brain development [GO:0007420]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]; social behavior [GO:0035176]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; brain development [GO:0007420]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]; social behavior [GO:0035176]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Q96RK4	reviewed	BBS4_HUMAN	Bardet-Biedl syndrome 4 protein	BBS4	Homo sapiens (Human)	519	FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. {ECO:0000269|PubMed:15107855, ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.		adult behavior [GO:0030534]; brain morphogenesis [GO:0048854]; centrosome cycle [GO:0007098]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; dendrite development [GO:0016358]; face development [GO:0060324]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; gene expression [GO:0010467]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; intracellular transport [GO:0046907]; maintenance of protein location in nucleus [GO:0051457]; melanosome transport [GO:0032402]; microtubule anchoring at centrosome [GO:0034454]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of gene expression [GO:0010629]; negative regulation of systemic arterial blood pressure [GO:0003085]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of cilium assembly [GO:0045724]; positive regulation of multicellular organism growth [GO:0040018]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; protein localization to organelle [GO:0033365]; protein localization to photoreceptor outer segment [GO:1903546]; protein transport [GO:0015031]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of cytokinesis [GO:0032465]; regulation of lipid metabolic process [GO:0019216]; regulation of non-motile cilium assembly [GO:1902855]; regulation of stress fiber assembly [GO:0051492]; retina homeostasis [GO:0001895]; retinal rod cell development [GO:0046548]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893]; social behavior [GO:0035176]; spermatid development [GO:0007286]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual perception [GO:0007601]	BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; dynactin binding [GO:0034452]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; dynactin binding [GO:0034452]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; adult behavior [GO:0030534]; brain morphogenesis [GO:0048854]; centrosome cycle [GO:0007098]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; dendrite development [GO:0016358]; face development [GO:0060324]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; gene expression [GO:0010467]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; intracellular transport [GO:0046907]; maintenance of protein location in nucleus [GO:0051457]; melanosome transport [GO:0032402]; microtubule anchoring at centrosome [GO:0034454]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of gene expression [GO:0010629]; negative regulation of systemic arterial blood pressure [GO:0003085]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of cilium assembly [GO:0045724]; positive regulation of multicellular organism growth [GO:0040018]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; protein localization to organelle [GO:0033365]; protein localization to photoreceptor outer segment [GO:1903546]; protein transport [GO:0015031]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of cytokinesis [GO:0032465]; regulation of lipid metabolic process [GO:0019216]; regulation of non-motile cilium assembly [GO:1902855]; regulation of stress fiber assembly [GO:0051492]; retina homeostasis [GO:0001895]; retinal rod cell development [GO:0046548]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893]; social behavior [GO:0035176]; spermatid development [GO:0007286]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell projection, cilium membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8C1Z7}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8C1Z7}. Note=Localizes to the pericentriolar material. Centrosomal localization requires dynein (By similarity). Localizes to the connecting cilium of photoreceptor cells (By similarity). {ECO:0000250|UniProtKB:Q8C1Z7}.
Q96RL1	reviewed	UIMC1_HUMAN	BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1)	UIMC1 RAP80 RXRIP110	Homo sapiens (Human)	719	FUNCTION: Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}.		chromatin organization [GO:0006325]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA repair [GO:0045739]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]	BRCA1-A complex [GO:0070531]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	DNA binding [GO:0003677]; histone binding [GO:0042393]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; ubiquitin modification-dependent histone binding [GO:0061649]	BRCA1-A complex [GO:0070531]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; DNA binding [GO:0003677]; histone binding [GO:0042393]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; ubiquitin modification-dependent histone binding [GO:0061649]; chromatin organization [GO:0006325]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA repair [GO:0045739]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Q96RL6	reviewed	SIG11_HUMAN	Sialic acid-binding Ig-like lectin 11 (Sialic acid-binding lectin 11) (Siglec-11)	SIGLEC11 UNQ9222/PRO28718	Homo sapiens (Human)	698	FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.		cell adhesion [GO:0007155]	plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; phosphatase binding [GO:0019902]; sialic acid binding [GO:0033691]	plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; phosphatase binding [GO:0019902]; sialic acid binding [GO:0033691]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q96RL7	reviewed	VP13A_HUMAN	Intermembrane lipid transfer protein VPS13A (Chorea-acanthocytosis protein) (Chorein) (Vacuolar protein sorting-associated protein 13A)	VPS13A CHAC KIAA0986	Homo sapiens (Human)	3174	FUNCTION: Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids (PubMed:34830155). Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria (PubMed:30741634). Negatively regulates lipid droplet size and motility (PubMed:30741634). Required for efficient lysosomal protein degradation (PubMed:30709847). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:30709847, ECO:0000269|PubMed:30741634, ECO:0000269|PubMed:34830155}.		autophagy [GO:0006914]; flagellated sperm motility [GO:0030317]; Golgi to endosome transport [GO:0006895]; lipid transport [GO:0006869]; locomotory behavior [GO:0007626]; lysosomal protein catabolic process [GO:1905146]; nervous system development [GO:0007399]; protein localization [GO:0008104]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]; social behavior [GO:0035176]; sperm mitochondrion organization [GO:0030382]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extrinsic component of membrane [GO:0019898]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; neuronal dense core vesicle lumen [GO:0099013]; sperm midpiece [GO:0097225]		cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extrinsic component of membrane [GO:0019898]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; neuronal dense core vesicle lumen [GO:0099013]; sperm midpiece [GO:0097225]; autophagy [GO:0006914]; flagellated sperm motility [GO:0030317]; Golgi to endosome transport [GO:0006895]; lipid transport [GO:0006869]; locomotory behavior [GO:0007626]; lysosomal protein catabolic process [GO:1905146]; nervous system development [GO:0007399]; protein localization [GO:0008104]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]; social behavior [GO:0035176]; sperm mitochondrion organization [GO:0030382]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:30093493, ECO:0000269|PubMed:30709847, ECO:0000269|PubMed:30741634}; Peripheral membrane protein {ECO:0000269|PubMed:30741634}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30709847, ECO:0000269|PubMed:30741634, ECO:0000269|PubMed:32845802}; Peripheral membrane protein {ECO:0000269|PubMed:30741634}. Endosome membrane {ECO:0000269|PubMed:30709847}; Peripheral membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:30709847}; Peripheral membrane protein {ECO:0000305}. Lipid droplet {ECO:0000269|PubMed:30093493, ECO:0000269|PubMed:30709847, ECO:0000269|PubMed:30741634, ECO:0000269|PubMed:32845802}. Golgi apparatus {ECO:0000250|UniProtKB:Q5H8C4}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle {ECO:0000250|UniProtKB:Q5H8C4}. Note=Localizes at mitochondria-endosomes and mitochondria-endoplasmic reticulum contact sites (PubMed:30741634, PubMed:30709847, PubMed:30093493). {ECO:0000269|PubMed:30093493, ECO:0000269|PubMed:30709847, ECO:0000269|PubMed:30741634}.
Q96RN1	reviewed	S26A8_HUMAN	Testis anion transporter 1 (Anion exchange transporter) (Solute carrier family 26 member 8)	SLC26A8 TAT1	Homo sapiens (Human)	970	FUNCTION: Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane (PubMed:11834742, PubMed:11278976). Stimulates anion transport activity of CFTR (PubMed:22121115, PubMed:23582645). May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation (By similarity). May play a role in sperm tail differentiation and motility and hence male fertility (By similarity). {ECO:0000250|UniProtKB:Q8R0C3, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:22121115, ECO:0000269|PubMed:23582645}.		cell differentiation [GO:0030154]; chloride transport [GO:0006821]; meiotic cell cycle [GO:0051321]; oxalate transport [GO:0019532]; spermatogenesis [GO:0007283]; sulfate transport [GO:0008272]	plasma membrane [GO:0005886]; sperm annulus [GO:0097227]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:chloride antiporter activity [GO:0160044]	plasma membrane [GO:0005886]; sperm annulus [GO:0097227]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:chloride antiporter activity [GO:0160044]; cell differentiation [GO:0030154]; chloride transport [GO:0006821]; meiotic cell cycle [GO:0051321]; oxalate transport [GO:0019532]; spermatogenesis [GO:0007283]; sulfate transport [GO:0008272]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11278976}; Multi-pass membrane protein {ECO:0000255}. Note=Located at both the annulus and the equatorial segment of the human sperm head. {ECO:0000269|PubMed:17517695, ECO:0000269|PubMed:22121115, ECO:0000269|PubMed:23582645}.
Q96RN5	reviewed	MED15_HUMAN	Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)	MED15 ARC105 CTG7A PCQAP TIG1 TNRC7	Homo sapiens (Human)	788	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269|PubMed:12167862, ECO:0000269|PubMed:16630888, ECO:0000269|PubMed:16799563}.		positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]	core mediator complex [GO:0070847]; cytoplasm [GO:0005737]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; cytoplasm [GO:0005737]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coregulator activity [GO:0003712]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q96RP3	reviewed	UCN2_HUMAN	Urocortin-2 (Stresscopin-related peptide) (Urocortin II) (Ucn II) (Urocortin-related peptide)	UCN2 SRP URP	Homo sapiens (Human)	112	FUNCTION: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to nutrient levels [GO:0031669]; digestion [GO:0007586]; hormone-mediated signaling pathway [GO:0009755]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	corticotropin-releasing hormone receptor 2 binding [GO:0051431]; corticotropin-releasing hormone receptor binding [GO:0051429]; hormone activity [GO:0005179]; hormone binding [GO:0042562]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; corticotropin-releasing hormone receptor 2 binding [GO:0051431]; corticotropin-releasing hormone receptor binding [GO:0051429]; hormone activity [GO:0005179]; hormone binding [GO:0042562]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to nutrient levels [GO:0031669]; digestion [GO:0007586]; hormone-mediated signaling pathway [GO:0009755]	SUBCELLULAR LOCATION: Secreted.
Q96RP7	reviewed	G3ST4_HUMAN	Galactose-3-O-sulfotransferase 4 (Gal3ST-4) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 4) (Gal-beta-1,3-GalNAc 3'-sulfotransferase)	GAL3ST4 PP6968	Homo sapiens (Human)	486	FUNCTION: Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc. {ECO:0000269|PubMed:11333265}.		cell-cell signaling [GO:0007267]; glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101]; glycoprotein metabolic process [GO:0009100]; oligosaccharide metabolic process [GO:0009311]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790]	extracellular exosome [GO:0070062]; Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]	3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; galactose 3-O-sulfotransferase activity [GO:0050694]; galactosylceramide sulfotransferase activity [GO:0001733]; proteoglycan sulfotransferase activity [GO:0050698]	extracellular exosome [GO:0070062]; Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]; 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; galactose 3-O-sulfotransferase activity [GO:0050694]; galactosylceramide sulfotransferase activity [GO:0001733]; proteoglycan sulfotransferase activity [GO:0050698]; cell-cell signaling [GO:0007267]; glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101]; glycoprotein metabolic process [GO:0009100]; oligosaccharide metabolic process [GO:0009311]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q96RP9	reviewed	EFGM_HUMAN	Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (hEFG1)	GFM1 EFG EFG1 GFM	Homo sapiens (Human)	751	FUNCTION: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03061, ECO:0000269|PubMed:19716793}.		mitochondrial translational elongation [GO:0070125]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; mitochondrial translational elongation [GO:0070125]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03061}.
Q96RQ1	reviewed	ERGI2_HUMAN	Endoplasmic reticulum-Golgi intermediate compartment protein 2	ERGIC2 ERV41 PTX1 CDA14	Homo sapiens (Human)	377	FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000250}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; retrograde transporter complex, Golgi to ER [GO:0061852]; transporter complex [GO:1990351]		COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; retrograde transporter complex, Golgi to ER [GO:0061852]; transporter complex [GO:1990351]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Note=Cycles between the endoplasmic reticulum and the Golgi. According to a report, localizes to the nucleus (PubMed:11445006). Another report shows a partial localization in the nucleus (PubMed:17980171). {ECO:0000269|PubMed:11445006, ECO:0000269|PubMed:17980171}.
Q96RQ3	reviewed	MCCA_HUMAN	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)	MCCC1 MCCA	Homo sapiens (Human)	725	FUNCTION: Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195, ECO:0000269|PubMed:32561715}.		biotin metabolic process [GO:0006768]; branched-chain amino acid catabolic process [GO:0009083]; leucine catabolic process [GO:0006552]	3-methylcrotonyl-CoA carboxylase complex, mitochondrial [GO:0002169]; cytosol [GO:0005829]; methylcrotonoyl-CoA carboxylase complex [GO:1905202]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; biotin binding [GO:0009374]; biotin carboxylase activity [GO:0004075]; metal ion binding [GO:0046872]; methylcrotonoyl-CoA carboxylase activity [GO:0004485]	3-methylcrotonyl-CoA carboxylase complex, mitochondrial [GO:0002169]; cytosol [GO:0005829]; methylcrotonoyl-CoA carboxylase complex [GO:1905202]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; biotin binding [GO:0009374]; biotin carboxylase activity [GO:0004075]; metal ion binding [GO:0046872]; methylcrotonoyl-CoA carboxylase activity [GO:0004485]; biotin metabolic process [GO:0006768]; branched-chain amino acid catabolic process [GO:0009083]; leucine catabolic process [GO:0006552]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:16023992}.
Q96RQ9	reviewed	OXLA_HUMAN	L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (EC 1.4.3.25) (Interleukin-4-induced protein 1) (IL4-induced protein 1) (hIL4I1) (Protein Fig-1) (hFIG1)	IL4I1 FIG1 UNQ636/PRO1265	Homo sapiens (Human)	567	FUNCTION: Secreted L-amino-acid oxidase that acts as a key immunoregulator (PubMed:17356132, PubMed:32818467, PubMed:32866000). Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively (PubMed:17356132, PubMed:32818467, PubMed:32866000). Also has weak L-arginine oxidase activity (PubMed:26673964). Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR (PubMed:32818467, PubMed:32866000). IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer (PubMed:32818467, PubMed:32866000). AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T-cells (Treg) and regulates the development and function of B-cells (PubMed:17356132, PubMed:25446972, PubMed:25778793, PubMed:28891065). Also regulates M2 macrophage polarization by inhibiting T-cell activation (By similarity). Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2 (PubMed:23355881). {ECO:0000250|UniProtKB:O09046, ECO:0000269|PubMed:17356132, ECO:0000269|PubMed:23355881, ECO:0000269|PubMed:25446972, ECO:0000269|PubMed:25778793, ECO:0000269|PubMed:26673964, ECO:0000269|PubMed:28891065, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000}.	MISCELLANEOUS: [Isoform 2]: Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62. {ECO:0000305|PubMed:16029492}.	adaptive immune response [GO:0002250]; amino acid catabolic process [GO:0009063]; L-phenylalanine catabolic process [GO:0006559]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of adaptive immune response [GO:0002819]; regulation of B cell differentiation [GO:0045577]; tryptophan catabolic process [GO:0006569]; tryptophan catabolic process to indole-3-acetate [GO:0019440]; tyrosine catabolic process [GO:0006572]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; lysosome [GO:0005764]; sperm midpiece [GO:0097225]	L-amino-acid oxidase activity [GO:0001716]; L-phenylalaine oxidase activity [GO:0106329]; polyamine oxidase activity [GO:0046592]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; lysosome [GO:0005764]; sperm midpiece [GO:0097225]; L-amino-acid oxidase activity [GO:0001716]; L-phenylalaine oxidase activity [GO:0106329]; polyamine oxidase activity [GO:0046592]; adaptive immune response [GO:0002250]; amino acid catabolic process [GO:0009063]; L-phenylalanine catabolic process [GO:0006559]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of adaptive immune response [GO:0002819]; regulation of B cell differentiation [GO:0045577]; tryptophan catabolic process [GO:0006569]; tryptophan catabolic process to indole-3-acetate [GO:0019440]; tyrosine catabolic process [GO:0006572]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17356132, ECO:0000269|PubMed:28891065, ECO:0000269|PubMed:32818467}. Lysosome {ECO:0000250|UniProtKB:O09046}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:25767141}. Note=Secreted at the immunological synapse. {ECO:0000269|PubMed:28891065}.
Q96RR1	reviewed	PEO1_HUMAN	Twinkle mtDNA helicase (EC 3.6.4.12) (Progressive external ophthalmoplegia 1 protein) (T7 gp4-like protein with intramitochondrial nucleoid localization) (T7-like mitochondrial DNA helicase) (Twinkle protein, mitochondrial)	TWNK C10orf2 PEO1	Homo sapiens (Human)	684	FUNCTION: [Isoform 1]: Mitochondrial helicase involved in mtDNA replication and repair (PubMed:12975372, PubMed:15167897, PubMed:17324440, PubMed:18039713, PubMed:18971204, PubMed:25824949, PubMed:26887820, PubMed:27226550). Might have a role in mtDNA repair (PubMed:27226550). Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB (PubMed:12975372, PubMed:15167897, PubMed:18039713, PubMed:22383523, PubMed:26887820, PubMed:27226550). Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate (PubMed:12975372, PubMed:15167897, PubMed:18039713, PubMed:22383523, PubMed:26887820, PubMed:27226550). Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand (PubMed:27226550). In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities (PubMed:22383523, PubMed:26887820, PubMed:27226550). {ECO:0000269|PubMed:12975372, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:17324440, ECO:0000269|PubMed:18039713, ECO:0000269|PubMed:18971204, ECO:0000269|PubMed:22383523, ECO:0000269|PubMed:25824949, ECO:0000269|PubMed:26887820, ECO:0000269|PubMed:27226550}.; FUNCTION: [Isoform 2]: Lack DNA unwinding and ATP hydrolysis activities (PubMed:18039713). Does not bind single-stranded or double-stranded DNA (PubMed:18039713). {ECO:0000269|PubMed:18039713}.		cellular response to glucose stimulus [GO:0071333]; DNA unwinding involved in DNA replication [GO:0006268]; mitochondrial DNA replication [GO:0006264]; mitochondrial transcription [GO:0006390]; protein hexamerization [GO:0034214]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; single-stranded DNA binding [GO:0003697]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; single-stranded DNA binding [GO:0003697]; cellular response to glucose stimulus [GO:0071333]; DNA unwinding involved in DNA replication [GO:0006268]; mitochondrial DNA replication [GO:0006264]; mitochondrial transcription [GO:0006390]; protein hexamerization [GO:0034214]	SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:11431692, ECO:0000269|PubMed:18971204}. Note=Colocalizes with mtDNA in mitochondrial nucleoids, a nucleoproteins complex consisting of a number of copies of proteins associated with mtDNA, probably involved in mtDNA maintenance and expression. {ECO:0000269|PubMed:11431692}.
Q96RR4	reviewed	KKCC2_HUMAN	Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)	CAMKK2 CAMKKB KIAA0787	Homo sapiens (Human)	588	FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}.	MISCELLANEOUS: [Isoform 1]: Major isoform.; MISCELLANEOUS: [Isoform 2]: Major isoform. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Inactive. Does not activate CAMK1 and CAMK4. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Inactive. Does not activate CAMK1 and CAMK4. {ECO:0000305}.	calcium-mediated signaling [GO:0019722]; CAMKK-AMPK signaling cascade [GO:0061762]; cellular response to reactive oxygen species [GO:0034614]; MAPK cascade [GO:0000165]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of protein kinase activity [GO:0045859]	cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; calcium-mediated signaling [GO:0019722]; CAMKK-AMPK signaling cascade [GO:0061762]; cellular response to reactive oxygen species [GO:0034614]; MAPK cascade [GO:0000165]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of protein kinase activity [GO:0045859]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21957496}. Cytoplasm {ECO:0000269|PubMed:21957496}. Cell projection, neuron projection {ECO:0000269|PubMed:21957496}. Note=Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction. {ECO:0000269|PubMed:21957496}.
Q96RS0	reviewed	TGS1_HUMAN	Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N2 methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT)	TGS1 HCA137 NCOA6IP PIMT	Homo sapiens (Human)	853	FUNCTION: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}.		7-methylguanosine cap hypermethylation [GO:0036261]; 7-methylguanosine RNA capping [GO:0009452]; ribonucleoprotein complex biogenesis [GO:0022613]; spliceosomal snRNP assembly [GO:0000387]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]	RNA methyltransferase activity [GO:0008173]; RNA trimethylguanosine synthase activity [GO:0071164]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; RNA methyltransferase activity [GO:0008173]; RNA trimethylguanosine synthase activity [GO:0071164]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; 7-methylguanosine cap hypermethylation [GO:0036261]; 7-methylguanosine RNA capping [GO:0009452]; ribonucleoprotein complex biogenesis [GO:0022613]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12943661}. Nucleus, Cajal body {ECO:0000305|PubMed:12032086}. Nucleus, nucleolus {ECO:0000269|PubMed:12032086}. Note=A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network. {ECO:0000269|PubMed:12943661}.
Q96RS6	reviewed	NUDC1_HUMAN	NudC domain-containing protein 1 (Chronic myelogenous leukemia tumor antigen 66) (Tumor antigen CML66)	NUDCD1 CML66	Homo sapiens (Human)	583		MISCELLANEOUS: Isoform 1 is the dominant immunogenic isoform and is capable of eliciting a humoral response in individuals with a variety of solid tumors. Expression of isoform 1 in a wide variety of malignancies as well as the presence of an immunogenic epitope suggest that it may be a suitable target for antigen-specific immunotherapy. {ECO:0000269|PubMed:11416219, ECO:0000269|PubMed:14688378}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	immune system process [GO:0002376]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; immune system process [GO:0002376]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.
Q96RT1	reviewed	ERBIN_HUMAN	Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)	ERBIN ERBB2IP KIAA1225 LAP2	Homo sapiens (Human)	1412	FUNCTION: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.		basal protein localization [GO:0045175]; cell adhesion [GO:0007155]; cellular response to tumor necrosis factor [GO:0071356]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; integrin-mediated signaling pathway [GO:0007229]; intermediate filament cytoskeleton organization [GO:0045104]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; protein targeting [GO:0006605]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; signal transduction [GO:0007165]	basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; hemidesmosome [GO:0030056]; neuromuscular junction [GO:0031594]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic specialization [GO:0099572]	ErbB-2 class receptor binding [GO:0005176]; signaling receptor binding [GO:0005102]; structural constituent of cytoskeleton [GO:0005200]	basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; hemidesmosome [GO:0030056]; neuromuscular junction [GO:0031594]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic specialization [GO:0099572]; ErbB-2 class receptor binding [GO:0005176]; signaling receptor binding [GO:0005102]; structural constituent of cytoskeleton [GO:0005200]; basal protein localization [GO:0045175]; cell adhesion [GO:0007155]; cellular response to tumor necrosis factor [GO:0071356]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; integrin-mediated signaling pathway [GO:0007229]; intermediate filament cytoskeleton organization [GO:0045104]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; protein targeting [GO:0006605]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell junction, hemidesmosome {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:11375975}. Nucleus membrane {ECO:0000250}. Basolateral cell membrane {ECO:0000269|PubMed:16203728}. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.
Q96RT7	reviewed	GCP6_HUMAN	Gamma-tubulin complex component 6 (GCP-6)	TUBGCP6 GCP6 KIAA1669	Homo sapiens (Human)	1819	FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. {ECO:0000269|PubMed:11694571}.		cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; membrane [GO:0016020]; microtubule [GO:0005874]; spindle pole [GO:0000922]	gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; membrane [GO:0016020]; microtubule [GO:0005874]; spindle pole [GO:0000922]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:14654843}.
Q96RT8	reviewed	GCP5_HUMAN	Gamma-tubulin complex component 5 (GCP-5)	TUBGCP5 GCP5 KIAA1899	Homo sapiens (Human)	1024	FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.		cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; microtubule [GO:0005874]; spindle pole [GO:0000922]	gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; microtubule [GO:0005874]; spindle pole [GO:0000922]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}.
Q96RU2	reviewed	UBP28_HUMAN	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)	USP28 KIAA1515	Homo sapiens (Human)	1077	FUNCTION: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}.		cell population proliferation [GO:0008283]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; regulation of protein stability [GO:0031647]; response to ionizing radiation [GO:0010212]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; cell population proliferation [GO:0008283]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; regulation of protein stability [GO:0031647]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17558397}.
Q96RU3	reviewed	FNBP1_HUMAN	Formin-binding protein 1 (Formin-binding protein 17) (hFBP17)	FNBP1 FBP17 KIAA0554	Homo sapiens (Human)	617	FUNCTION: May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}.		endocytosis [GO:0006897]; signal transduction [GO:0007165]	cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; lipid binding [GO:0008289]	cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; endocytosis [GO:0006897]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
Q96RU7	reviewed	TRIB3_HUMAN	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)	TRIB3 C20orf97 NIPK SKIP3 TRB3	Homo sapiens (Human)	358	FUNCTION: Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:15781252, PubMed:15775988). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PubMed:15781252, PubMed:15775988). May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PubMed:15781252, PubMed:15775988). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (By similarity). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PubMed:12736262). Interacts with MAPK kinases and regulates activation of MAP kinases (PubMed:15299019). Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230). {ECO:0000250|UniProtKB:Q8K4K2, ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252, ECO:0000269|PubMed:22977230}.		cellular response to insulin stimulus [GO:0032869]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; regulation of autophagy [GO:0010506]; regulation of glucose transmembrane transport [GO:0010827]; regulation of MAP kinase activity [GO:0043405]; response to endoplasmic reticulum stress [GO:0034976]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106]; cellular response to insulin stimulus [GO:0032869]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; regulation of autophagy [GO:0010506]; regulation of glucose transmembrane transport [GO:0010827]; regulation of MAP kinase activity [GO:0043405]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22977230}.
Q96RU8	reviewed	TRIB1_HUMAN	Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)	TRIB1 C8FW GIG2 TRB1	Homo sapiens (Human)	372	FUNCTION: Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797). {ECO:0000250|UniProtKB:Q8K4K4, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:26455797, ECO:0000305|PubMed:27041596}.		JNK cascade [GO:0007254]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of neutrophil differentiation [GO:0045659]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of eosinophil differentiation [GO:0045645]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of MAP kinase activity [GO:0043405]; response to lipopolysaccharide [GO:0032496]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase inhibitor activity [GO:0004860]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase inhibitor activity [GO:0004860]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106]; JNK cascade [GO:0007254]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of neutrophil differentiation [GO:0045659]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of eosinophil differentiation [GO:0045645]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of MAP kinase activity [GO:0043405]; response to lipopolysaccharide [GO:0032496]	
Q96RW7	reviewed	HMCN1_HUMAN	Hemicentin-1 (Fibulin-6) (FIBL-6)	HMCN1 FIBL6	Homo sapiens (Human)	5635	FUNCTION: Involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes (PubMed:29488390). Plays a role in basement membrane organization (By similarity). May promote cleavage furrow maturation during cytokinesis in preimplantation embryos (By similarity). May play a role in the architecture of adhesive and flexible epithelial cell junctions (By similarity). May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration (By similarity). {ECO:0000250|UniProtKB:D3YXG0, ECO:0000269|PubMed:29488390}.		actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell cycle [GO:0007049]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]	adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]	adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell cycle [GO:0007049]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:D3YXG0}. Cytoplasm {ECO:0000250|UniProtKB:D3YXG0}. Cell junction {ECO:0000250|UniProtKB:D3YXG0}. Cleavage furrow {ECO:0000250|UniProtKB:D3YXG0}. Note=Has been detected in the glomerular basement membrane in one study. However, another study found expression in the glomerular mesangial matrix but not in the glomerular basement membrane. The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2. {ECO:0000250|UniProtKB:D3YXG0}.
Q96RY7	reviewed	IF140_HUMAN	Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2)	IFT140 KIAA0590 WDTC2	Homo sapiens (Human)	1462	FUNCTION: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs) (PubMed:20889716, PubMed:22503633). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance (PubMed:22503633). Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity). {ECO:0000250|UniProtKB:E9PY46, ECO:0000269|PubMed:20889716, ECO:0000269|PubMed:22503633, ECO:0000269|PubMed:28724397}.		cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; heart development [GO:0007507]; intraciliary retrograde transport [GO:0035721]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; photoreceptor cell outer segment organization [GO:0035845]; protein localization to cilium [GO:0061512]; regulation of cilium assembly [GO:1902017]; regulation of smoothened signaling pathway [GO:0008589]	axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cone photoreceptor outer segment [GO:0120199]; intraciliary transport particle A [GO:0030991]; photoreceptor connecting cilium [GO:0032391]		axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cone photoreceptor outer segment [GO:0120199]; intraciliary transport particle A [GO:0030991]; photoreceptor connecting cilium [GO:0032391]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; heart development [GO:0007507]; intraciliary retrograde transport [GO:0035721]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; photoreceptor cell outer segment organization [GO:0035845]; protein localization to cilium [GO:0061512]; regulation of cilium assembly [GO:1902017]; regulation of smoothened signaling pathway [GO:0008589]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22503633, ECO:0000269|PubMed:26968735}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23418020}. Cell projection, cilium {ECO:0000269|PubMed:22503633, ECO:0000269|PubMed:26968735, ECO:0000269|PubMed:27932497}.
Q96S06	reviewed	LMF1_HUMAN	Lipase maturation factor 1 (Transmembrane protein 112)	LMF1 C16orf26 TMEM112 HMFN1876 JFP11	Homo sapiens (Human)	567	FUNCTION: Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL. {ECO:0000250|UniProtKB:Q3U3R4, ECO:0000269|PubMed:24909692}.		protein maturation [GO:0051604]; triglyceride metabolic process [GO:0006641]	endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]; protein maturation [GO:0051604]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24909692}; Multi-pass membrane protein {ECO:0000269|PubMed:24909692}.
Q96S15	reviewed	WDR24_HUMAN	GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24)	WDR24 C16orf21 JFP7	Homo sapiens (Human)	790	FUNCTION: Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:26449471, PubMed:26586190, PubMed:27487210, PubMed:36528027, PubMed:35831510, PubMed:36732624). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:26449471, PubMed:26586190, PubMed:27487210, PubMed:36528027, PubMed:35831510, PubMed:36732624). GATOR2 probably acts as a E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027, PubMed:36732624). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027, PubMed:36732624). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the mTORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823). Within the GATOR2 complex, WDR24 constitutes the catalytic subunit that mediates 'Lys-6'-linked ubiquitination of NPRL2 (PubMed:36528027, PubMed:36732624). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:26449471, ECO:0000269|PubMed:26586190, ECO:0000269|PubMed:27166823, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027, ECO:0000269|PubMed:36732624}.		autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein K6-linked ubiquitination [GO:0085020]; regulation of autophagy [GO:0010506]	cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; vacuolar membrane [GO:0005774]	ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; vacuolar membrane [GO:0005774]; ubiquitin protein ligase activity [GO:0061630]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein K6-linked ubiquitination [GO:0085020]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28199306}.
Q96S16	reviewed	JMJD8_HUMAN	JmjC domain-containing protein 8 (Jumonji domain-containing protein 8)	JMJD8 C16orf20 PP14397	Homo sapiens (Human)	264	FUNCTION: Functions as a positive regulator of TNF-induced NF-kappa-B signaling (PubMed:27671354). Regulates angiogenesis and cellular metabolism through interaction with PKM (PubMed:27199445). {ECO:0000269|PubMed:27199445, ECO:0000269|PubMed:27671354}.		positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of glycolytic process [GO:0006110]; regulation of pyruvate kinase activity [GO:1903302]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; nucleus [GO:0005634]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of glycolytic process [GO:0006110]; regulation of pyruvate kinase activity [GO:1903302]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:29133832}. Cytoplasm {ECO:0000269|PubMed:27199445}.
Q96S21	reviewed	RB40C_HUMAN	Ras-related protein Rab-40C (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3)	RAB40C RARL RASL8C	Homo sapiens (Human)	281	FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}.		intracellular signal transduction [GO:0035556]; protein localization to plasma membrane [GO:0072659]; protein ubiquitination [GO:0016567]	endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular signal transduction [GO:0035556]; protein localization to plasma membrane [GO:0072659]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q96S37	reviewed	S22AC_HUMAN	Solute carrier family 22 member 12 (Organic anion transporter 4-like protein) (Renal-specific transporter) (RST) (Urate anion exchanger 1) (URAT1) (Urate:anion antiporter SLC22A12)	SLC22A12 OATL4 URAT1 UNQ6453/PRO34004	Homo sapiens (Human)	553	FUNCTION: Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:12024214, PubMed:22194875, PubMed:35144162, PubMed:35462902). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:12024214, PubMed:22194875). Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:12024214). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (PubMed:12024214). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption (PubMed:21350910). Orotate transport is Cl(-)-dependent (PubMed:21350910). {ECO:0000269|PubMed:12024214, ECO:0000269|PubMed:21350910, ECO:0000269|PubMed:22194875, ECO:0000269|PubMed:35144162, ECO:0000269|PubMed:35462902}.		cellular homeostasis [GO:0019725]; cellular response to insulin stimulus [GO:0032869]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; renal urate salt excretion [GO:0097744]; response to xenobiotic stimulus [GO:0009410]; urate metabolic process [GO:0046415]; urate transport [GO:0015747]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	PDZ domain binding [GO:0030165]; urate transmembrane transporter activity [GO:0015143]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; PDZ domain binding [GO:0030165]; urate transmembrane transporter activity [GO:0015143]; cellular homeostasis [GO:0019725]; cellular response to insulin stimulus [GO:0032869]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; renal urate salt excretion [GO:0097744]; response to xenobiotic stimulus [GO:0009410]; urate metabolic process [GO:0046415]; urate transport [GO:0015747]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12024214, ECO:0000269|PubMed:22194875, ECO:0000269|PubMed:35144162, ECO:0000269|PubMed:35462902}; Multi-pass membrane protein {ECO:0000255}.
Q96S38	reviewed	KS6C1_HUMAN	Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein)	RPS6KC1 RPK118	Homo sapiens (Human)	1066	FUNCTION: May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}.		phosphorylation [GO:0016310]; signal transduction [GO:0007165]	early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020]	ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020]; ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. Membrane {ECO:0000269|PubMed:12077123}. Early endosome {ECO:0000269|PubMed:15750338}.
Q96S42	reviewed	NODAL_HUMAN	Nodal homolog	NODAL	Homo sapiens (Human)	347	FUNCTION: Essential for mesoderm formation and axial patterning during embryonic development. {ECO:0000250}.		axial mesodermal cell fate specification [GO:0048327]; brain development [GO:0007420]; cell migration involved in gastrulation [GO:0042074]; cell population proliferation [GO:0008283]; digestive tract morphogenesis [GO:0048546]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic pattern specification [GO:0009880]; embryonic placenta development [GO:0001892]; embryonic process involved in female pregnancy [GO:0060136]; endodermal cell differentiation [GO:0035987]; epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification [GO:0060802]; floor plate morphogenesis [GO:0033505]; formation of anatomical boundary [GO:0048859]; germ cell development [GO:0007281]; heart looping [GO:0001947]; inhibition of neuroepithelial cell differentiation [GO:0002085]; left lung morphogenesis [GO:0060460]; liver development [GO:0001889]; maternal placenta development [GO:0001893]; maternal process involved in parturition [GO:0060137]; mesendoderm development [GO:0048382]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell development [GO:0010721]; negative regulation of chorionic trophoblast cell proliferation [GO:1901383]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of trophoblast cell migration [GO:1901164]; neural fold formation [GO:0001842]; nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900164]; placenta development [GO:0001890]; polarity specification of proximal/distal axis [GO:0010085]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900224]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; primitive streak formation [GO:0090009]; regulation of gastrulation [GO:0010470]; regulation of stem cell population maintenance [GO:2000036]; SMAD protein signal transduction [GO:0060395]; somatic stem cell population maintenance [GO:0035019]; trophectodermal cellular morphogenesis [GO:0001831]; vasculature development [GO:0001944]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; morphogen activity [GO:0016015]; type I activin receptor binding [GO:0070698]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; morphogen activity [GO:0016015]; type I activin receptor binding [GO:0070698]; axial mesodermal cell fate specification [GO:0048327]; brain development [GO:0007420]; cell migration involved in gastrulation [GO:0042074]; cell population proliferation [GO:0008283]; digestive tract morphogenesis [GO:0048546]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic pattern specification [GO:0009880]; embryonic placenta development [GO:0001892]; embryonic process involved in female pregnancy [GO:0060136]; endodermal cell differentiation [GO:0035987]; epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification [GO:0060802]; floor plate morphogenesis [GO:0033505]; formation of anatomical boundary [GO:0048859]; germ cell development [GO:0007281]; heart looping [GO:0001947]; inhibition of neuroepithelial cell differentiation [GO:0002085]; left lung morphogenesis [GO:0060460]; liver development [GO:0001889]; maternal placenta development [GO:0001893]; maternal process involved in parturition [GO:0060137]; mesendoderm development [GO:0048382]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell development [GO:0010721]; negative regulation of chorionic trophoblast cell proliferation [GO:1901383]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of trophoblast cell migration [GO:1901164]; neural fold formation [GO:0001842]; nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900164]; placenta development [GO:0001890]; polarity specification of proximal/distal axis [GO:0010085]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900224]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; primitive streak formation [GO:0090009]; regulation of gastrulation [GO:0010470]; regulation of stem cell population maintenance [GO:2000036]; SMAD protein signal transduction [GO:0060395]; somatic stem cell population maintenance [GO:0035019]; trophectodermal cellular morphogenesis [GO:0001831]; vasculature development [GO:0001944]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q96S44	reviewed	PRPK_HUMAN	EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase)	TP53RK C20orf64 PRPK	Homo sapiens (Human)	253	FUNCTION: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). {ECO:0000250|UniProtKB:P53323, ECO:0000250|UniProtKB:Q9UYB9, ECO:0000269|PubMed:11546806, ECO:0000305|PubMed:22912744, ECO:0000305|PubMed:27903914}.		protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; tRNA processing [GO:0008033]; tRNA threonylcarbamoyladenosine metabolic process [GO:0070525]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; tRNA processing [GO:0008033]; tRNA threonylcarbamoyladenosine metabolic process [GO:0070525]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28805828}. Nucleus {ECO:0000269|PubMed:22912744, ECO:0000269|PubMed:27903914, ECO:0000269|PubMed:28805828}.
Q96S52	reviewed	PIGS_HUMAN	GPI transamidase component PIG-S (Phosphatidylinositol-glycan biosynthesis class S protein)	PIGS UNQ1873/PRO4316	Homo sapiens (Human)	555	FUNCTION: Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. {ECO:0000269|PubMed:11483512, ECO:0000269|PubMed:30269814, ECO:0000269|PubMed:34576938}.		attachment of GPI anchor to protein [GO:0016255]	endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]		endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]; attachment of GPI anchor to protein [GO:0016255]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Multi-pass membrane protein {ECO:0000269|PubMed:11483512}.
Q96S53	reviewed	TESK2_HUMAN	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2)	TESK2	Homo sapiens (Human)	571	FUNCTION: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.		actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11418599}.
Q96S55	reviewed	WRIP1_HUMAN	ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1)	WRNIP1 WHIP	Homo sapiens (Human)	665	FUNCTION: Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:29053956}.		DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; innate immune response [GO:0045087]; regulation of DNA-templated DNA replication initiation [GO:0030174]	membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; single-stranded DNA helicase activity [GO:0017116]	membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; single-stranded DNA helicase activity [GO:0017116]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; innate immune response [GO:0045087]; regulation of DNA-templated DNA replication initiation [GO:0030174]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18842586}. Cytoplasm {ECO:0000269|PubMed:29053956}. Note=Colocalizes with WRN in granular structures in the nucleus. {ECO:0000269|PubMed:18842586, ECO:0000269|PubMed:29053956}.
Q96S59	reviewed	RANB9_HUMAN	Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7)	RANBP9 RANBPM	Homo sapiens (Human)	729	FUNCTION: May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}.		cytoskeleton organization [GO:0007010]; microtubule nucleation [GO:0007020]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; protein-containing complex assembly [GO:0065003]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	enzyme binding [GO:0019899]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; enzyme binding [GO:0019899]; small GTPase binding [GO:0031267]; cytoskeleton organization [GO:0007010]; microtubule nucleation [GO:0007020]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11470507, ECO:0000269|PubMed:14511641, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:24143168}. Nucleus {ECO:0000269|PubMed:11470507, ECO:0000269|PubMed:14511641, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:18222118}. Cell membrane {ECO:0000269|PubMed:14722085}; Peripheral membrane protein {ECO:0000269|PubMed:14722085}. Note=The unphosphorylated form is predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane. {ECO:0000269|PubMed:14722085}.
Q96S65	reviewed	CSRN1_HUMAN	Cysteine/serine-rich nuclear protein 1 (CSRNP-1) (Axin-1 up-regulated gene 1 protein) (Protein URAX1) (TGF-beta-induced apoptosis protein 3) (TAIP-3)	CSRNP1 AXUD1 TAIP3	Homo sapiens (Human)	589	FUNCTION: Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis. {ECO:0000250, ECO:0000269|PubMed:11526492}.		apoptotic process [GO:0006915]; face morphogenesis [GO:0060325]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; apoptotic process [GO:0006915]; face morphogenesis [GO:0060325]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96S66	reviewed	CLCC1_HUMAN	Chloride channel CLIC-like protein 1 (Mid-1-related chloride channel protein 1)	CLCC1 KIAA0761 MCLC	Homo sapiens (Human)	551	FUNCTION: Seems to act as a chloride ion channel (PubMed:30157172). Plays a role in retina development (PubMed:30157172). {ECO:0000269|PubMed:30157172}.			chloride channel complex [GO:0034707]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; nuclear membrane [GO:0031965]	chloride channel activity [GO:0005254]	chloride channel complex [GO:0034707]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; nuclear membrane [GO:0031965]; chloride channel activity [GO:0005254]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30157172, ECO:0000269|PubMed:31653868}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9WU61}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:Q9WU61}; Multi-pass membrane protein {ECO:0000255}. Note=Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes. {ECO:0000269|PubMed:31653868}.
Q96S82	reviewed	UBL7_HUMAN	Ubiquitin-like protein 7 (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP) (Ubiquitin-like protein SB132)	UBL7 BMSCUBP SB132	Homo sapiens (Human)	380	FUNCTION: Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway. {ECO:0000269|PubMed:19690332}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of primary metabolic process [GO:0080090]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	molecular adaptor activity [GO:0060090]; polyubiquitin modification-dependent protein binding [GO:0031593]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; molecular adaptor activity [GO:0060090]; polyubiquitin modification-dependent protein binding [GO:0031593]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of primary metabolic process [GO:0080090]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q96S94	reviewed	CCNL2_HUMAN	Cyclin-L2 (Paneth cell-enhanced expression protein)	CCNL2 SB138	Homo sapiens (Human)	520	FUNCTION: Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. {ECO:0000269|PubMed:14684736, ECO:0000269|PubMed:18216018}.		regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of centrosome cycle [GO:0046605]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of centrosome cycle [GO:0046605]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:14684736, ECO:0000269|PubMed:18216018}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18216018}.
Q96S97	reviewed	MYADM_HUMAN	Myeloid-associated differentiation marker (Protein SB135)	MYADM UNQ553/PRO1110	Homo sapiens (Human)	322			establishment of endothelial barrier [GO:0061028]; membrane raft organization [GO:0031579]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of gene expression [GO:0010629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of protein kinase C signaling [GO:0090038]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cell migration [GO:0030335]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to plasma membrane raft [GO:0044860]	cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; ruffle [GO:0001726]		cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; establishment of endothelial barrier [GO:0061028]; membrane raft organization [GO:0031579]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of gene expression [GO:0010629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of protein kinase C signaling [GO:0090038]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cell migration [GO:0030335]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to plasma membrane raft [GO:0044860]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96S99	reviewed	PKHF1_HUMAN	Pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (PH and FYVE domain-containing protein 1) (Phafin-1) (Zinc finger FYVE domain-containing protein 15)	PLEKHF1 APPD LAPF ZFYVE15	Homo sapiens (Human)	279	FUNCTION: May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. {ECO:0000269|PubMed:16188880}.		apoptotic process [GO:0006915]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; positive regulation of autophagy [GO:0010508]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; protein localization to plasma membrane [GO:0072659]; vesicle organization [GO:0016050]	early endosome [GO:0005769]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]	early endosome [GO:0005769]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; apoptotic process [GO:0006915]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; positive regulation of autophagy [GO:0010508]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; protein localization to plasma membrane [GO:0072659]; vesicle organization [GO:0016050]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16188880}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16188880}. Lysosome {ECO:0000269|PubMed:16188880}. Note=Translocates to lysosome during apoptosis.
Q96SB3	reviewed	NEB2_HUMAN	Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)	PPP1R9B PPP1R6	Homo sapiens (Human)	817	FUNCTION: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration. {ECO:0000250, ECO:0000269|PubMed:19151759}.		actin filament depolymerization [GO:0030042]; actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to morphine [GO:0071315]; cellular response to peptide [GO:1901653]; cellular response to xenobiotic stimulus [GO:0071466]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; developmental process involved in reproduction [GO:0003006]; filopodium assembly [GO:0046847]; hippocampus development [GO:0021766]; learning [GO:0007612]; male mating behavior [GO:0060179]; negative regulation of cell growth [GO:0030308]; neuron projection development [GO:0031175]; positive regulation of protein localization to actin cortical patch [GO:1904372]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to actin cytoskeleton [GO:1903119]; protein localization to cell periphery [GO:1990778]; regulation of cell cycle [GO:0051726]; regulation of cell growth by extracellular stimulus [GO:0001560]; regulation of cell population proliferation [GO:0042127]; regulation of exit from mitosis [GO:0007096]; regulation of opioid receptor signaling pathway [GO:2000474]; regulation of protein phosphorylation [GO:0001932]; reproductive system development [GO:0061458]; response to amphetamine [GO:0001975]; response to immobilization stress [GO:0035902]; response to kainic acid [GO:1904373]; response to L-phenylalanine derivative [GO:1904386]; response to nicotine [GO:0035094]; response to prostaglandin E [GO:0034695]; response to steroid hormone [GO:0048545]; RNA splicing [GO:0008380]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic side of dendritic spine plasma membrane [GO:1990780]; dendrite [GO:0030425]; dendritic spine head [GO:0044327]; dendritic spine neck [GO:0044326]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein phosphatase type 1 complex [GO:0000164]; ruffle membrane [GO:0032587]	actin filament binding [GO:0051015]; D2 dopamine receptor binding [GO:0031749]; kinase binding [GO:0019900]; protein kinase activity [GO:0004672]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; transmembrane transporter binding [GO:0044325]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic side of dendritic spine plasma membrane [GO:1990780]; dendrite [GO:0030425]; dendritic spine head [GO:0044327]; dendritic spine neck [GO:0044326]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein phosphatase type 1 complex [GO:0000164]; ruffle membrane [GO:0032587]; actin filament binding [GO:0051015]; D2 dopamine receptor binding [GO:0031749]; kinase binding [GO:0019900]; protein kinase activity [GO:0004672]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; transmembrane transporter binding [GO:0044325]; actin filament depolymerization [GO:0030042]; actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to morphine [GO:0071315]; cellular response to peptide [GO:1901653]; cellular response to xenobiotic stimulus [GO:0071466]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; developmental process involved in reproduction [GO:0003006]; filopodium assembly [GO:0046847]; hippocampus development [GO:0021766]; learning [GO:0007612]; male mating behavior [GO:0060179]; negative regulation of cell growth [GO:0030308]; neuron projection development [GO:0031175]; positive regulation of protein localization to actin cortical patch [GO:1904372]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to actin cytoskeleton [GO:1903119]; protein localization to cell periphery [GO:1990778]; regulation of cell cycle [GO:0051726]; regulation of cell growth by extracellular stimulus [GO:0001560]; regulation of cell population proliferation [GO:0042127]; regulation of exit from mitosis [GO:0007096]; regulation of opioid receptor signaling pathway [GO:2000474]; regulation of protein phosphorylation [GO:0001932]; reproductive system development [GO:0061458]; response to amphetamine [GO:0001975]; response to immobilization stress [GO:0035902]; response to kainic acid [GO:1904373]; response to L-phenylalanine derivative [GO:1904386]; response to nicotine [GO:0035094]; response to prostaglandin E [GO:0034695]; response to steroid hormone [GO:0048545]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:O35274}. Postsynaptic density {ECO:0000250|UniProtKB:O35274}. Synapse. Cell junction, adherens junction {ECO:0000250}. Cytoplasm. Cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle membrane. Note=Enriched at synapse and cadherin-based cell-cell adhesion sites. In neurons, both cytosolic and membrane-associated, and highly enriched in the postsynaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells and in dendritic spines (By similarity). Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. {ECO:0000250}.
Q96SB4	reviewed	SRPK1_HUMAN	SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)	SRPK1	Homo sapiens (Human)	655	FUNCTION: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}.	MISCELLANEOUS: [Isoform 1]: Due to intron retention. {ECO:0000305}.	chromosome segregation [GO:0007059]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of viral genome replication [GO:0045071]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of mRNA processing [GO:0050684]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; sperm DNA condensation [GO:0035092]; spliceosomal complex assembly [GO:0000245]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; chromosome segregation [GO:0007059]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of viral genome replication [GO:0045071]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of mRNA processing [GO:0050684]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; sperm DNA condensation [GO:0035092]; spliceosomal complex assembly [GO:0000245]	SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus. Nucleus matrix. Microsome. Note=Shuttles between the nucleus and the cytoplasm. Inhibition of the Hsp90 ATPase activity, osmotic stress and interaction with HHV-1 ICP27 protein can induce its translocation to the nucleus. KAT5/TIP60 inhibits its nuclear translocation.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus matrix. Microsome. Note=Mainly localized in the microsomal fraction and the cytoplasm, and to a lesser extent in the nuclear matrix.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28076779}. Nucleus, nucleoplasm {ECO:0000269|PubMed:28076779}. Nucleus speckle {ECO:0000269|PubMed:28076779}. Chromosome {ECO:0000269|PubMed:28076779}. Note=Preferentially localizes to the promoter of gene coding regions. {ECO:0000269|PubMed:28076779}.
Q96SB8	reviewed	SMC6_HUMAN	Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)	SMC6 SMC6L1	Homo sapiens (Human)	1091	FUNCTION: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:26983541}.		cellular senescence [GO:0090398]; chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation by host of viral genome replication [GO:0044828]; positive regulation of chromosome segregation [GO:0051984]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]; telomere maintenance via recombination [GO:0000722]	chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; interchromatin granule [GO:0035061]; mitotic spindle pole [GO:0097431]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; sex chromosome [GO:0000803]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]	ATP binding [GO:0005524]; damaged DNA binding [GO:0003684]; DNA secondary structure binding [GO:0000217]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625]	chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; interchromatin granule [GO:0035061]; mitotic spindle pole [GO:0097431]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; sex chromosome [GO:0000803]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]; ATP binding [GO:0005524]; damaged DNA binding [GO:0003684]; DNA secondary structure binding [GO:0000217]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625]; cellular senescence [GO:0090398]; chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation by host of viral genome replication [GO:0044828]; positive regulation of chromosome segregation [GO:0051984]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]; telomere maintenance via recombination [GO:0000722]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11408570, ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:35263599}. Nucleus speckle {ECO:0000269|PubMed:11408570}. Chromosome {ECO:0000250|UniProtKB:Q924W5}. Nucleus, PML body {ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:36373674}. Chromosome, telomere {ECO:0000269|PubMed:17589526}. Note=Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity). Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). Localizes in interchromatin granule clusters (PubMed:11408570). {ECO:0000250|UniProtKB:Q924W5, ECO:0000269|PubMed:11408570, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:25931565}.
Q96SC8	reviewed	DMTA2_HUMAN	Doublesex- and mab-3-related transcription factor A2 (Doublesex- and mab-3-related transcription factor 5)	DMRTA2 DMRT5	Homo sapiens (Human)	542	FUNCTION: May be involved in sexual development.		cerebral cortex regionalization [GO:0021796]; dopaminergic neuron differentiation [GO:0071542]; germ cell development [GO:0007281]; neuroblast proliferation [GO:0007405]; neuron fate specification [GO:0048665]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]; skeletal muscle cell differentiation [GO:0035914]; stem cell fate specification [GO:0048866]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cerebral cortex regionalization [GO:0021796]; dopaminergic neuron differentiation [GO:0071542]; germ cell development [GO:0007281]; neuroblast proliferation [GO:0007405]; neuron fate specification [GO:0048665]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]; skeletal muscle cell differentiation [GO:0035914]; stem cell fate specification [GO:0048866]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Q96SD1	reviewed	DCR1C_HUMAN	Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein)	DCLRE1C ARTEMIS ASCID SCIDA SNM1C	Homo sapiens (Human)	692	FUNCTION: Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:15071507, PubMed:15574326, PubMed:11955432, PubMed:15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628). {ECO:0000269|PubMed:11336668, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:14744996, ECO:0000269|PubMed:15071507, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15468306, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:15574327, ECO:0000269|PubMed:15811628, ECO:0000269|PubMed:15936993}.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297]; response to ionizing radiation [GO:0010212]; telomere maintenance [GO:0000723]; V(D)J recombination [GO:0033151]	Golgi apparatus [GO:0005794]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]	5'-3' DNA exonuclease activity [GO:0035312]; 5'-3' exonuclease activity [GO:0008409]; damaged DNA binding [GO:0003684]; endonuclease activity [GO:0004519]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]	Golgi apparatus [GO:0005794]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; 5'-3' DNA exonuclease activity [GO:0035312]; 5'-3' exonuclease activity [GO:0008409]; damaged DNA binding [GO:0003684]; endonuclease activity [GO:0004519]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297]; response to ionizing radiation [GO:0010212]; telomere maintenance [GO:0000723]; V(D)J recombination [GO:0033151]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:15071507}.
Q96SF7	reviewed	TBX15_HUMAN	T-box transcription factor TBX15 (T-box protein 15) (T-box transcription factor TBX14) (T-box protein 14)	TBX15 TBX14	Homo sapiens (Human)	602	FUNCTION: Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: Gene prediction based on similarity to orthologs.	cell fate specification [GO:0001708]; embryonic cranial skeleton morphogenesis [GO:0048701]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; RNA polymerase II transcription repressor complex [GO:0090571]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; RNA polymerase II transcription repressor complex [GO:0090571]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell fate specification [GO:0001708]; embryonic cranial skeleton morphogenesis [GO:0048701]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Q96SI1	reviewed	KCD15_HUMAN	BTB/POZ domain-containing protein KCTD15 (Potassium channel tetramerization domain-containing protein 15)	KCTD15	Homo sapiens (Human)	283	FUNCTION: During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain. {ECO:0000250, ECO:0000269|PubMed:23382213}.		protein homooligomerization [GO:0051260]	nucleus [GO:0005634]	identical protein binding [GO:0042802]	nucleus [GO:0005634]; identical protein binding [GO:0042802]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8K0E1}. Note=In the brain, localizes to the arcuate hypothalamic nucleus, the ventromedial hypothalamic nucleus and the accumbens nucleus of the ventral striatum. {ECO:0000250|UniProtKB:Q8K0E1}.
Q96SI9	reviewed	STRBP_HUMAN	Spermatid perinuclear RNA-binding protein	STRBP SPNR	Homo sapiens (Human)	672	FUNCTION: Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity). {ECO:0000250}.		mechanosensory behavior [GO:0007638]; spermatid development [GO:0007286]	cytoplasm [GO:0005737]; manchette [GO:0002177]; nucleus [GO:0005634]	DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]	cytoplasm [GO:0005737]; manchette [GO:0002177]; nucleus [GO:0005634]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; mechanosensory behavior [GO:0007638]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Microtubule-associated that localizes to the manchette in developing spermatids. {ECO:0000250}.
Q96SL1	reviewed	DIRC2_HUMAN	Solute carrier family 49 member 4 (Disrupted in renal cancer protein 2) (Disrupted in renal carcinoma protein 2)	SLC49A4 DIRC2	Homo sapiens (Human)	478	FUNCTION: Mediates H(+)-dependent pyridoxine transport. {ECO:0000269|PubMed:21692750, ECO:0000269|PubMed:36456177}.		pyridoxine transport [GO:0031923]	intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]		intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; pyridoxine transport [GO:0031923]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:21692750, ECO:0000269|PubMed:36456177}; Multi-pass membrane protein {ECO:0000255}.
Q96SL4	reviewed	GPX7_HUMAN	Glutathione peroxidase 7 (GPx-7) (GSHPx-7) (EC 1.11.1.9) (CL683)	GPX7 GPX6 UNQ469/PRO828	Homo sapiens (Human)	187	FUNCTION: It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxygen species (ROS) and protects against oxidative DNA damage and double-strand breaks. {ECO:0000269|PubMed:22157330}.		cellular response to oxidative stress [GO:0034599]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]	catalase activity [GO:0004096]; glutathione peroxidase activity [GO:0004602]; peroxidase activity [GO:0004601]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; catalase activity [GO:0004096]; glutathione peroxidase activity [GO:0004602]; peroxidase activity [GO:0004601]; cellular response to oxidative stress [GO:0034599]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96SN8	reviewed	CK5P2_HUMAN	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215)	CDK5RAP2 CEP215 KIAA1633	Homo sapiens (Human)	1893	FUNCTION: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697}.		brain development [GO:0007420]; centriole replication [GO:0007099]; centrosome cycle [GO:0007098]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule organizing center organization [GO:0031023]; negative regulation of centriole replication [GO:0046600]; negative regulation of neuron differentiation [GO:0045665]; neurogenesis [GO:0022008]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; regulation of neuron differentiation [GO:0045664]	cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule plus-end [GO:0035371]; mitotic spindle pole [GO:0097431]; pericentriolar material [GO:0000242]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922]	calmodulin binding [GO:0005516]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription cis-regulatory region binding [GO:0000976]; tubulin binding [GO:0015631]	cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule plus-end [GO:0035371]; mitotic spindle pole [GO:0097431]; pericentriolar material [GO:0000242]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922]; calmodulin binding [GO:0005516]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription cis-regulatory region binding [GO:0000976]; tubulin binding [GO:0015631]; brain development [GO:0007420]; centriole replication [GO:0007099]; centrosome cycle [GO:0007098]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule organizing center organization [GO:0031023]; negative regulation of centriole replication [GO:0046600]; negative regulation of neuron differentiation [GO:0045665]; neurogenesis [GO:0022008]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; regulation of neuron differentiation [GO:0045664]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:31974111}. Golgi apparatus {ECO:0000269|PubMed:20466722}. Cytoplasm {ECO:0000269|PubMed:19553473}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573}. Note=Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Localizes to microtubule plus ends in the presence of EB1/MAPRE1. Localization to centrosomes versus Golgi apparatus may be cell type-dependent. For instance, in SK-BR-3 and HEK293F cells, localizes to centrosomes but not to the Golgi apparatus (PubMed:29162697). {ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697}.
Q96SQ5	reviewed	ZN587_HUMAN	Zinc finger protein 587	ZNF587	Homo sapiens (Human)	575	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96SQ7	reviewed	ATOH8_HUMAN	Transcription factor ATOH8 (Class A basic helix-loop-helix protein 21) (bHLHa21) (Helix-loop-helix protein hATH-6) (hATH6) (Protein atonal homolog 8)	ATOH8 ATH6 BHLHA21	Homo sapiens (Human)	321	FUNCTION: Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (PubMed:24236640). Regulates endothelial cell proliferation, migration and tube-like structures formation (PubMed:24463812). Modulates endothelial cell differentiation through NOS3 (PubMed:24463812). May be implicated in specification and differentiation of neuronal cell lineages in the brain (By similarity). May participate in kidney development and may be involved in podocyte differentiation (By similarity). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (By similarity). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (By similarity). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (PubMed:24236640). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (By similarity). {ECO:0000250|UniProtKB:Q99NA2, ECO:0000269|PubMed:24236640, ECO:0000269|PubMed:24463812}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; formation of primary germ layer [GO:0001704]; myoblast proliferation [GO:0051450]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; SMAD protein signal transduction [GO:0060395]; tube formation [GO:0035148]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; formation of primary germ layer [GO:0001704]; myoblast proliferation [GO:0051450]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; SMAD protein signal transduction [GO:0060395]; tube formation [GO:0035148]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24463812}. Nucleus speckle {ECO:0000269|PubMed:24463812}. Cytoplasm {ECO:0000250|UniProtKB:Q99NA2}.
Q96SQ9	reviewed	CP2S1_HUMAN	Cytochrome P450 2S1 (EC 1.14.14.-) (CYPIIS1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Thromboxane-A synthase) (EC 5.3.99.5)	CYP2S1 UNQ891/PRO1906	Homo sapiens (Human)	504	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195). In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195). {ECO:0000269|PubMed:12711469, ECO:0000269|PubMed:21068195}.		epoxygenase P450 pathway [GO:0019373]; icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693]; retinoic acid metabolic process [GO:0042573]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	12-hydroxyheptadecatrienoic acid synthase activity [GO:0036134]; arachidonic acid epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; hydro-lyase activity [GO:0016836]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]; thromboxane-A synthase activity [GO:0004796]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; 12-hydroxyheptadecatrienoic acid synthase activity [GO:0036134]; arachidonic acid epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; hydro-lyase activity [GO:0016836]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]; thromboxane-A synthase activity [GO:0004796]; epoxygenase P450 pathway [GO:0019373]; icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693]; retinoic acid metabolic process [GO:0042573]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11181079}; Peripheral membrane protein {ECO:0000269|PubMed:11181079}. Microsome membrane {ECO:0000269|PubMed:11181079}; Peripheral membrane protein {ECO:0000269|PubMed:11181079}.
Q96ST2	reviewed	IWS1_HUMAN	Protein IWS1 homolog (IWS1-like protein)	IWS1 IWS1L	Homo sapiens (Human)	819	FUNCTION: Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}.		chromatin remodeling [GO:0006338]; mRNA processing [GO:0006397]; poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; RNA splicing [GO:0008380]; transcription elongation-coupled chromatin remodeling [GO:0140673]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin remodeling [GO:0006338]; mRNA processing [GO:0006397]; poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; RNA splicing [GO:0008380]; transcription elongation-coupled chromatin remodeling [GO:0140673]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649, ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882}.
Q96ST3	reviewed	SIN3A_HUMAN	Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)	SIN3A	Homo sapiens (Human)	1273	FUNCTION: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}.		activation of innate immune response [GO:0002218]; cellular response to dopamine [GO:1903351]; cellular response to glucose stimulus [GO:0071333]; cerebral cortex neuron differentiation [GO:0021895]; DNA replication [GO:0006260]; hematopoietic progenitor cell differentiation [GO:0002244]; heterochromatin formation [GO:0031507]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of stem cell population maintenance [GO:1902459]; protein localization [GO:0008104]; regulation of axon extension [GO:0030516]; regulation of hormone levels [GO:0010817]; regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619]; response to methylglyoxal [GO:0051595]; rhythmic process [GO:0048511]; type I interferon-mediated signaling pathway [GO:0060337]	chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]	chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; activation of innate immune response [GO:0002218]; cellular response to dopamine [GO:1903351]; cellular response to glucose stimulus [GO:0071333]; cerebral cortex neuron differentiation [GO:0021895]; DNA replication [GO:0006260]; hematopoietic progenitor cell differentiation [GO:0002244]; heterochromatin formation [GO:0031507]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of stem cell population maintenance [GO:1902459]; protein localization [GO:0008104]; regulation of axon extension [GO:0030516]; regulation of hormone levels [GO:0010817]; regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619]; response to methylglyoxal [GO:0051595]; rhythmic process [GO:0048511]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810, ECO:0000269|PubMed:16820529}. Nucleus, nucleolus {ECO:0000269|PubMed:16820529}. Note=Recruited to the nucleolus by SAP30L.
Q96ST8	reviewed	CEP89_HUMAN	Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123)	CEP89 CCDC123	Homo sapiens (Human)	783	FUNCTION: Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}.		chemical synaptic transmission [GO:0007268]; cilium assembly [GO:0060271]; mitochondrion organization [GO:0007005]; non-motile cilium assembly [GO:1905515]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; spindle pole [GO:0000922]; synapse [GO:0045202]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; spindle pole [GO:0000922]; synapse [GO:0045202]; chemical synaptic transmission [GO:0007268]; cilium assembly [GO:0060271]; mitochondrion organization [GO:0007005]; non-motile cilium assembly [GO:1905515]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Mitochondrion intermembrane space. Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane.
Q96SU4	reviewed	OSBL9_HUMAN	Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9)	OSBPL9 ORP9 OSBP4	Homo sapiens (Human)	736			bile acid biosynthetic process [GO:0006699]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; membrane [GO:0016020]	sterol binding [GO:0032934]; sterol transporter activity [GO:0015248]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; sterol binding [GO:0032934]; sterol transporter activity [GO:0015248]; bile acid biosynthetic process [GO:0006699]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:20599956}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:20599956}. Note=Localizes at the Golgi-late endosome interface.
Q96SW2	reviewed	CRBN_HUMAN	Protein cereblon	CRBN AD-006	Homo sapiens (Human)	442	FUNCTION: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2 (PubMed:33009960). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (PubMed:20223979, PubMed:24328678, PubMed:25043012, PubMed:25108355). Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons (PubMed:18414909, PubMed:29530986). Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (PubMed:18414909). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity). Plays a negative role in TLR4 signaling by interacting with TRAF6 and ECSIT, leading to inhibition of ECSIT ubiquitination, an important step of the signaling (PubMed:31620128). {ECO:0000250|UniProtKB:Q8C7D2, ECO:0000269|PubMed:18414909, ECO:0000269|PubMed:20223979, ECO:0000269|PubMed:24328678, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355, ECO:0000269|PubMed:29530986, ECO:0000269|PubMed:31620128}.	MISCELLANEOUS: Thalidomide was widely prescribed to pregnant women in the late 1950s as a sedative and as treatment against morning sickness. Thalidomide was found to be teratogenic, causing multiple birth defects. Recently, thalidomide use has increased for the treatment of multiple myeloma and erythema nodosum leprosum, a painful complication of leprosy. Binding of pomalidomide and other thalidomide-related drugs leads to a change in substrate specificity of the human DCX (DDB1-CUL4-X-box) E3 protein ligase complex, and this is probably the underlying cause of the teratogenic activity of thalidomide, possibly due to abnormal regulation of the BMP and FGF8 signaling pathways (PubMed:20223979). The thalidomide-induced change in substrate specificity leads to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3, and this is probably the reason for the anti-proliferative and immunomodulatory effects of thalidomide and related drugs (PubMed:25108355). Thalidomide is also teratogenic in chicken and zebrafish, but not in mice. {ECO:0000305|PubMed:20223979, ECO:0000305|PubMed:25108355}.	locomotory exploration behavior [GO:0035641]; negative regulation of monoatomic ion transmembrane transport [GO:0034766]; negative regulation of protein-containing complex assembly [GO:0031333]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of Wnt signaling pathway [GO:0030177]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]	Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]; locomotory exploration behavior [GO:0035641]; negative regulation of monoatomic ion transmembrane transport [GO:0034766]; negative regulation of protein-containing complex assembly [GO:0031333]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of Wnt signaling pathway [GO:0030177]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20223979}. Nucleus {ECO:0000269|PubMed:20223979}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q96SZ4	reviewed	ZSC10_HUMAN	Zinc finger and SCAN domain-containing protein 10 (Zinc finger protein 206)	ZSCAN10 ZNF206	Homo sapiens (Human)	725	FUNCTION: Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4. {ECO:0000250|UniProtKB:Q3URR7}.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q96SZ5	reviewed	AEDO_HUMAN	2-aminoethanethiol dioxygenase (EC 1.13.11.19) (Cysteamine dioxygenase)	ADO C10orf22	Homo sapiens (Human)	270	FUNCTION: Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate (PubMed:17581819, PubMed:29752763, PubMed:31273118, PubMed:32601061). Catalyzes the oxidation of cysteamine (2-aminoethanethiol) to hypotaurine (PubMed:17581819, PubMed:29752763, PubMed:32601061). Catalyzes the oxidation of regulators of G-protein signaling 4 (RGS4) and 5 (RGS5) and interleukin-32 (IL32) (PubMed:31273118, PubMed:32601061). {ECO:0000269|PubMed:17581819, ECO:0000269|PubMed:29752763, ECO:0000269|PubMed:31273118, ECO:0000269|PubMed:32601061}.		cellular response to hypoxia [GO:0071456]	cytosol [GO:0005829]	cysteamine dioxygenase activity [GO:0047800]; iron ion binding [GO:0005506]	cytosol [GO:0005829]; cysteamine dioxygenase activity [GO:0047800]; iron ion binding [GO:0005506]; cellular response to hypoxia [GO:0071456]	
Q96SZ6	reviewed	CK5P1_HUMAN	Mitochondrial tRNA methylthiotransferase CDK5RAP1 (EC 2.8.4.3) (CDK5 activator-binding protein C42) (CDK5 regulatory subunit-associated protein 1) (mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase) (mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase)	CDK5RAP1 C20orf34 CGI-05 HSPC167	Homo sapiens (Human)	601	FUNCTION: Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:22422838, PubMed:25738458, PubMed:28981754). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:22422838, PubMed:25738458, PubMed:28981754). Specifically inhibits CDK5 activation by CDK5R1 (PubMed:11882646). Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease (PubMed:25738458). {ECO:0000269|PubMed:11882646, ECO:0000269|PubMed:22422838, ECO:0000269|PubMed:25738458, ECO:0000269|PubMed:28981754}.	MISCELLANEOUS: [Isoform 1]: May be due to intron retention.; MISCELLANEOUS: [Isoform 2]: Absence of the mitochondrial target sequence which may lead to miss-localization. {ECO:0000303|PubMed:25738458}.	brain development [GO:0007420]; mitochondrial tRNA modification [GO:0070900]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of translational fidelity [GO:0045903]; regulation of neuron differentiation [GO:0045664]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; N6-isopentenyladenosine methylthiotransferase activity [GO:0035597]; protein kinase binding [GO:0019901]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; N6-isopentenyladenosine methylthiotransferase activity [GO:0035597]; protein kinase binding [GO:0019901]; brain development [GO:0007420]; mitochondrial tRNA modification [GO:0070900]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of translational fidelity [GO:0045903]; regulation of neuron differentiation [GO:0045664]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22422838}.
Q96T21	reviewed	SEBP2_HUMAN	Selenocysteine insertion sequence-binding protein 2 (SECIS-binding protein 2)	SECISBP2 SBP2	Homo sapiens (Human)	854	FUNCTION: Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.	MISCELLANEOUS: [Isoform 2]: Contains a transit peptide at positions 1-15. {ECO:0000305}.	forebrain neuron development [GO:0021884]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; selenocysteine incorporation [GO:0001514]; striatum development [GO:0021756]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]	DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; selenocysteine insertion sequence binding [GO:0035368]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; selenocysteine insertion sequence binding [GO:0035368]; forebrain neuron development [GO:0021884]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; selenocysteine incorporation [GO:0001514]; striatum development [GO:0021756]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000269|PubMed:19004874}.
Q96T23	reviewed	RSF1_HUMAN	Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex)	RSF1 HBXAP XAP8	Homo sapiens (Human)	1441	FUNCTION: Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}.		chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA-templated transcription initiation [GO:0006352]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of viral transcription [GO:0050434]; regulation of DNA-templated transcription [GO:0006355]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSF complex [GO:0031213]	histone binding [GO:0042393]; histone octamer slider activity [GO:0140751]; metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSF complex [GO:0031213]; histone binding [GO:0042393]; histone octamer slider activity [GO:0140751]; metal ion binding [GO:0046872]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA-templated transcription initiation [GO:0006352]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of viral transcription [GO:0050434]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596}. Note=Localization is diffuse during mitosis (PubMed:12972596). Co-localizes with SMARCA5 in the nucleus (PubMed:12972596). {ECO:0000269|PubMed:12972596}.
Q96T37	reviewed	RBM15_HUMAN	RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15)	RBM15 OTT OTT1	Homo sapiens (Human)	977	FUNCTION: RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}.	MISCELLANEOUS: [Isoform 4]: Produced by alternative initiation of isoform 2. {ECO:0000305}.	branching involved in blood vessel morphogenesis [GO:0001569]; dosage compensation by inactivation of X chromosome [GO:0009048]; negative regulation of myeloid cell differentiation [GO:0045638]; placenta blood vessel development [GO:0060674]; positive regulation of transcription of Notch receptor target [GO:0007221]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of megakaryocyte differentiation [GO:0045652]; RNA methylation [GO:0001510]; spleen development [GO:0048536]; thrombopoietin-mediated signaling pathway [GO:0038163]; ventricular septum morphogenesis [GO:0060412]	nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; branching involved in blood vessel morphogenesis [GO:0001569]; dosage compensation by inactivation of X chromosome [GO:0009048]; negative regulation of myeloid cell differentiation [GO:0045638]; placenta blood vessel development [GO:0060674]; positive regulation of transcription of Notch receptor target [GO:0007221]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of megakaryocyte differentiation [GO:0045652]; RNA methylation [GO:0001510]; spleen development [GO:0048536]; thrombopoietin-mediated signaling pathway [GO:0038163]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:24100041}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:24100041}. Nucleus envelope {ECO:0000269|PubMed:19586903}. Nucleus membrane {ECO:0000269|PubMed:19786495}; Peripheral membrane protein {ECO:0000269|PubMed:19786495}. Note=Colocalizes at the nuclear pore with DBP5 and NXF1. {ECO:0000269|PubMed:19786495}.
Q96T49	reviewed	PP16B_HUMAN	Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP)	PPP1R16B ANKRD4 KIAA0823	Homo sapiens (Human)	567	FUNCTION: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934). {ECO:0000250|UniProtKB:Q8VHQ3, ECO:0000250|UniProtKB:Q95N27, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:25007873, ECO:0000269|PubMed:26497934}.		establishment of endothelial barrier [GO:0061028]; negative regulation of peptidyl-serine dephosphorylation [GO:1902309]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of filopodium assembly [GO:0051489]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of protein dephosphorylation [GO:0035304]; regulation of sprouting angiogenesis [GO:1903670]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]; protein phosphatase regulator activity [GO:0019888]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]; protein phosphatase regulator activity [GO:0019888]; establishment of endothelial barrier [GO:0061028]; negative regulation of peptidyl-serine dephosphorylation [GO:1902309]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of filopodium assembly [GO:0051489]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of protein dephosphorylation [GO:0035304]; regulation of sprouting angiogenesis [GO:1903670]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:26497934}. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Nucleus {ECO:0000269|PubMed:18586956}. Cell projection {ECO:0000269|PubMed:25007873}. Note=Colocalizes with RPSA/LAMR1 in the cell membrane (PubMed:16263087). Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections (PubMed:25007873). {ECO:0000250|UniProtKB:Q95N27, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:25007873}.
Q96T51	reviewed	RUFY1_HUMAN	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12)	RUFY1 RABIP4 ZFYVE12	Homo sapiens (Human)	708	FUNCTION: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. {ECO:0000269|PubMed:14617813}.		endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; small GTPase mediated signal transduction [GO:0007264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]	identical protein binding [GO:0042802]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Q96T52	reviewed	IMP2L_HUMAN	Mitochondrial inner membrane protease subunit 2 (EC 3.4.21.-) (IMP2-like protein)	IMMP2L	Homo sapiens (Human)	175	FUNCTION: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. {ECO:0000269|PubMed:15814844}.		blood circulation [GO:0008015]; brain development [GO:0007420]; cerebellum vasculature development [GO:0061300]; DNA damage response [GO:0006974]; mitochondrial respiratory chain complex assembly [GO:0033108]; ovarian follicle development [GO:0001541]; ovulation [GO:0030728]; protein processing involved in protein targeting to mitochondrion [GO:0006627]; respiratory electron transport chain [GO:0022904]; signal peptide processing [GO:0006465]; spermatogenesis [GO:0007283]; superoxide metabolic process [GO:0006801]	mitochondrial inner membrane [GO:0005743]; mitochondrial inner membrane peptidase complex [GO:0042720]	endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	mitochondrial inner membrane [GO:0005743]; mitochondrial inner membrane peptidase complex [GO:0042720]; endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; blood circulation [GO:0008015]; brain development [GO:0007420]; cerebellum vasculature development [GO:0061300]; DNA damage response [GO:0006974]; mitochondrial respiratory chain complex assembly [GO:0033108]; ovarian follicle development [GO:0001541]; ovulation [GO:0030728]; protein processing involved in protein targeting to mitochondrion [GO:0006627]; respiratory electron transport chain [GO:0022904]; signal peptide processing [GO:0006465]; spermatogenesis [GO:0007283]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:15814844}; Single-pass membrane protein {ECO:0000305|PubMed:15814844}.
Q96T53	reviewed	MBOA4_HUMAN	Ghrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4)	MBOAT4 GOAT OACT4 FKSG89	Homo sapiens (Human)	435	FUNCTION: Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (PubMed:24045953, PubMed:18443287, PubMed:25562443, PubMed:28134508). In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient (PubMed:18443287). {ECO:0000269|PubMed:18443287, ECO:0000269|PubMed:24045953, ECO:0000269|PubMed:25562443, ECO:0000269|PubMed:28134508}.		lipid modification [GO:0030258]; peptide hormone processing [GO:0016486]; peptidyl-serine octanoylation [GO:0018191]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; O-acyltransferase activity [GO:0008374]; serine O-acyltransferase activity [GO:0016412]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; O-acyltransferase activity [GO:0008374]; serine O-acyltransferase activity [GO:0016412]; lipid modification [GO:0030258]; peptide hormone processing [GO:0016486]; peptidyl-serine octanoylation [GO:0018191]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P0C7A3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P0C7A3}.
Q96T54	reviewed	KCNKH_HUMAN	Potassium channel subfamily K member 17 (2P domain potassium channel Talk-2) (Acid-sensitive potassium channel protein TASK-4) (TWIK-related acid-sensitive K(+) channel 4) (TWIK-related alkaline pH-activated K(+) channel 2) (TALK-2)	KCNK17 TALK2 TASK4 UNQ5816/PRO19634	Homo sapiens (Human)	332	FUNCTION: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.	MISCELLANEOUS: Inhibited by Ba(2+), quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.	potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; stabilization of membrane potential [GO:0030322]	plasma membrane [GO:0005886]	outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q96T55	reviewed	KCNKG_HUMAN	Potassium channel subfamily K member 16 (2P domain potassium channel Talk-1) (TWIK-related alkaline pH-activated K(+) channel 1) (TALK-1)	KCNK16 TALK1	Homo sapiens (Human)	309	FUNCTION: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.	MISCELLANEOUS: Inhibited by Ba(2+), quinine, quinidine, chloroform and halothane. Activated at alkaline pH.	potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; stabilization of membrane potential [GO:0030322]	plasma membrane [GO:0005886]	outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q96T58	reviewed	MINT_HUMAN	Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)	SPEN KIAA0929 MINT SHARP	Homo sapiens (Human)	3664	FUNCTION: May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of neurogenesis [GO:0050769]; regulation of transcription by RNA polymerase II [GO:0006357]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of neurogenesis [GO:0050769]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11331609}. Note=Associates with chromatin.
Q96T60	reviewed	PNKP_HUMAN	Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]	PNKP	Homo sapiens (Human)	521	FUNCTION: Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways (PubMed:10446192, PubMed:10446193, PubMed:15385968, PubMed:20852255, PubMed:28453785). Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone (PubMed:10446192, PubMed:10446193). {ECO:0000269|PubMed:10446192, ECO:0000269|PubMed:10446193, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:28453785}.		base-excision repair, gap-filling [GO:0006287]; DNA ligation involved in DNA repair [GO:0051103]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of protein ADP-ribosylation [GO:0010836]; nucleotide-excision repair [GO:0006289]; phosphorylation [GO:0016310]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; response to oxidative stress [GO:0006979]; response to radiation [GO:0009314]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; damaged DNA binding [GO:0003684]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; polynucleotide 3'-phosphatase activity [GO:0046403]; purine nucleotide binding [GO:0017076]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; damaged DNA binding [GO:0003684]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; polynucleotide 3'-phosphatase activity [GO:0046403]; purine nucleotide binding [GO:0017076]; base-excision repair, gap-filling [GO:0006287]; DNA ligation involved in DNA repair [GO:0051103]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of protein ADP-ribosylation [GO:0010836]; nucleotide-excision repair [GO:0006289]; phosphorylation [GO:0016310]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; response to oxidative stress [GO:0006979]; response to radiation [GO:0009314]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10446193}. Chromosome {ECO:0000269|PubMed:28453785}. Note=Localizes to site of double-strand breaks. {ECO:0000269|PubMed:28453785}.
Q96T66	reviewed	NMNA3_HUMAN	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 (NMN/NaMN adenylyltransferase 3) (Nicotinamide-nucleotide adenylyltransferase 3) (NMN adenylyltransferase 3) (Nicotinate-nucleotide adenylyltransferase 3) (NaMN adenylyltransferase 3) (EC 2.7.7.18) (Pyridine nucleotide adenylyltransferase 3) (PNAT-3) (EC 2.7.7.1)	NMNAT3 FKSG76	Homo sapiens (Human)	252	FUNCTION: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. {ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.		NAD biosynthetic process [GO:0009435]; nucleotide biosynthetic process [GO:0009165]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; NAD biosynthetic process [GO:0009435]; nucleotide biosynthetic process [GO:0009165]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12574164, ECO:0000269|PubMed:16118205}.
Q96T68	reviewed	SETB2_HUMAN	Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2)	SETDB2 C13orf4 CLLD8 KMT1F	Homo sapiens (Human)	719	FUNCTION: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. {ECO:0000269|PubMed:20404330}.		cell division [GO:0051301]; chromosome segregation [GO:0007059]; heart looping [GO:0001947]; heterochromatin organization [GO:0070828]; left/right axis specification [GO:0070986]; methylation [GO:0032259]; mitotic cell cycle [GO:0000278]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; zinc ion binding [GO:0008270]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; heart looping [GO:0001947]; heterochromatin organization [GO:0070828]; left/right axis specification [GO:0070986]; methylation [GO:0032259]; mitotic cell cycle [GO:0000278]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20404330}. Chromosome {ECO:0000305|PubMed:20404330}.
Q96T76	reviewed	MMS19_HUMAN	MMS19 nucleotide excision repair protein homolog (hMMS19) (MET18 homolog) (MMS19-like protein)	MMS19 MMS19L	Homo sapiens (Human)	1030	FUNCTION: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity (PubMed:29848660). In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678362, PubMed:22678361, PubMed:29225034, PubMed:23585563). As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur (Fe-S) cluster assembly into ERCC2/XPD (PubMed:20797633). Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660). Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery (PubMed:11279242). {ECO:0000269|PubMed:11279242, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:22678361, ECO:0000269|PubMed:22678362, ECO:0000269|PubMed:23585563, ECO:0000269|PubMed:29225034, ECO:0000269|PubMed:29848660}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; iron-sulfur cluster assembly [GO:0016226]; nucleotide-excision repair [GO:0006289]; phosphorelay signal transduction system [GO:0000160]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; response to hormone [GO:0009725]	CIA complex [GO:0097361]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; transcription factor TFIIH holo complex [GO:0005675]	enzyme binding [GO:0019899]; nuclear estrogen receptor binding [GO:0030331]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor complex adaptor activity [GO:0030159]; transcription coactivator activity [GO:0003713]	CIA complex [GO:0097361]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; transcription factor TFIIH holo complex [GO:0005675]; enzyme binding [GO:0019899]; nuclear estrogen receptor binding [GO:0030331]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor complex adaptor activity [GO:0030159]; transcription coactivator activity [GO:0003713]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; iron-sulfur cluster assembly [GO:0016226]; nucleotide-excision repair [GO:0006289]; phosphorelay signal transduction system [GO:0000160]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; response to hormone [GO:0009725]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20797633}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:29848660}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29848660}. Note=In mitosis, enriched on centrosomes during prophase, localizes to the spindle during metaphase and surrounds compacted spindle midzone microtubules during telophase. {ECO:0000269|PubMed:29848660}.
Q96T83	reviewed	SL9A7_HUMAN	Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Solute carrier family 9 member 7)	SLC9A7 NHE7	Homo sapiens (Human)	725	FUNCTION: Golgi Na(+), K(+)/(H+) antiporter. Mediates the electoneutral influx of Na(+) or K(+) in exchange for H(+). May contribute to the regulation of Golgi apparatus volume and pH. {ECO:0000269|PubMed:11279194, ECO:0000269|PubMed:30335141}.		monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of Golgi lumen acidification [GO:1905526]; regulation of intracellular pH [GO:0051453]; regulation of pH [GO:0006885]; sodium ion import across plasma membrane [GO:0098719]	Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]	potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of Golgi lumen acidification [GO:1905526]; regulation of intracellular pH [GO:0051453]; regulation of pH [GO:0006885]; sodium ion import across plasma membrane [GO:0098719]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15840657, ECO:0000269|PubMed:20364249, ECO:0000269|PubMed:30335141}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:15840657}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30335141}; Multi-pass membrane protein {ECO:0000255}.
Q96T88	reviewed	UHRF1_HUMAN	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	UHRF1 ICBP90 NP95 RNF106	Homo sapiens (Human)	793	FUNCTION: Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF1 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751}.		cell cycle [GO:0007049]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; epigenetic regulation of gene expression [GO:0040029]; heterochromatin formation [GO:0031507]; homologous recombination [GO:0035825]; negative regulation of gene expression via CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoubiquitination [GO:0051865]; regulation of epithelial cell proliferation [GO:0050678]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromatin [GO:0000785]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA damage sensor activity [GO:0140612]; H3K9me3 modified histone binding [GO:0062072]; hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3 ubiquitin ligase activity [GO:0141055]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; methylated histone binding [GO:0035064]; nucleic acid binding [GO:0003676]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA damage sensor activity [GO:0140612]; H3K9me3 modified histone binding [GO:0062072]; hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3 ubiquitin ligase activity [GO:0141055]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; methylated histone binding [GO:0035064]; nucleic acid binding [GO:0003676]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; epigenetic regulation of gene expression [GO:0040029]; heterochromatin formation [GO:0031507]; homologous recombination [GO:0035825]; negative regulation of gene expression via CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoubiquitination [GO:0051865]; regulation of epithelial cell proliferation [GO:0050678]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00358, ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:30335751}. Note=Associated, through the YDG domain (also called SRA domain), with replicating DNA from early to late S phase, including at replicating pericentric heterochromatin (By similarity). Also localizes to euchromatic regions. In non-S-phase cells, homogenously distributed through the nucleus (By similarity). {ECO:0000250|UniProtKB:Q8VDF2}.
Q96T91	reviewed	GPHA2_HUMAN	Glycoprotein hormone alpha-2 (Putative secreted protein Zsig51) (Thyrostimulin subunit alpha)	GPHA2 GPA2 ZSIG51	Homo sapiens (Human)	129	FUNCTION: Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258). Plays a central role in controlling thyroid cell metabolism (PubMed:12045258). {ECO:0000269|PubMed:12045258}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	hormone activity [GO:0005179]; protein heterodimerization activity [GO:0046982]; thyrotropin-releasing hormone receptor binding [GO:0031531]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; protein heterodimerization activity [GO:0046982]; thyrotropin-releasing hormone receptor binding [GO:0031531]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Secreted.
Q96TA1	reviewed	NIBA2_HUMAN	Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B)	NIBAN2 C9orf88 FAM129B	Homo sapiens (Human)	746	FUNCTION: May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}.		axon guidance [GO:0007411]; cell differentiation [GO:0030154]; gonadotropin secretion [GO:0032274]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gene expression via CpG island demethylation [GO:0044029]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of transcription regulatory region DNA binding [GO:2000679]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; transcription coactivator activity [GO:0003713]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; transcription coactivator activity [GO:0003713]; axon guidance [GO:0007411]; cell differentiation [GO:0030154]; gonadotropin secretion [GO:0032274]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gene expression via CpG island demethylation [GO:0044029]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of transcription regulatory region DNA binding [GO:2000679]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell junction, adherens junction. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.
Q96TA2	reviewed	YMEL1_HUMAN	ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1)	YME1L1 FTSH1 YME1L UNQ1868/PRO4304	Homo sapiens (Human)	773	FUNCTION: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26923599, PubMed:27786171). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461). {ECO:0000269|PubMed:18076378, ECO:0000269|PubMed:22262461, ECO:0000269|PubMed:26923599, ECO:0000269|PubMed:27495975, ECO:0000269|PubMed:27786171}.	MISCELLANEOUS: [Isoform 2]: Mutagenesis of Glu-543 to Gln does not complement excessive accumulation of subunits (NDUFB6, COX4,ND1) due to YME1 deletion mutant. Probably has no ATPase activity. {ECO:0000305}.	cell population proliferation [GO:0008283]; mitochondrial protein catabolic process [GO:0035694]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; protein hexamerization [GO:0034214]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; cell population proliferation [GO:0008283]; mitochondrial protein catabolic process [GO:0035694]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; protein hexamerization [GO:0034214]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:10843804, ECO:0000269|PubMed:22262461}. Mitochondrion {ECO:0000269|PubMed:26923599, ECO:0000269|PubMed:27495975}.
Q96TC7	reviewed	RMD3_HUMAN	Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51)	RMDN3 FAM82A2 FAM82C PTPIP51 hucep-10 UNQ3122/PRO10274	Homo sapiens (Human)	470	FUNCTION: Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}.		apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; intracellular calcium ion homeostasis [GO:0006874]	cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]; organelle membrane contact site [GO:0044232]; spindle microtubule [GO:0005876]	microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]; organelle membrane contact site [GO:0044232]; spindle microtubule [GO:0005876]; microtubule binding [GO:0008017]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; intracellular calcium ion homeostasis [GO:0006874]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:17361080, ECO:0000269|PubMed:22131369, ECO:0000269|PubMed:29858488}; Single-pass membrane protein {ECO:0000269|PubMed:16820967}. Cytoplasm {ECO:0000269|PubMed:17361080}. Nucleus {ECO:0000269|PubMed:17361080}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18070910}. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. {ECO:0000269|PubMed:18070910}.
Q99062	reviewed	CSF3R_HUMAN	Granulocyte colony-stimulating factor receptor (G-CSF receptor) (G-CSF-R) (CD antigen CD114)	CSF3R GCSFR	Homo sapiens (Human)	836	FUNCTION: Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. {ECO:0000269|PubMed:7514305}.	MISCELLANEOUS: Mutations in CSF3R acquired in multipotent hematopoietic progenitor cells and resulting in truncated hyper-responsive forms of the receptor, have been identified in most cases of severe congenital neutropenia (SCN). Patients carrying these mutations are at risk for developing myelodysplastic syndromes and/or acute myeloid leukemia. Constitutive mutations leading to hyporesponsive forms of the receptor are responsible for the refractoriness to CSF3 treatment observed in some SCN patients.	amelogenesis [GO:0097186]; cell adhesion [GO:0007155]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; neutrophil chemotaxis [GO:0030593]; regulation of myeloid cell differentiation [GO:0045637]; signal transduction [GO:0007165]	endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; granulocyte colony-stimulating factor binding [GO:0051916]; signaling receptor activity [GO:0038023]	endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; granulocyte colony-stimulating factor binding [GO:0051916]; signaling receptor activity [GO:0038023]; amelogenesis [GO:0097186]; cell adhesion [GO:0007155]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; neutrophil chemotaxis [GO:0030593]; regulation of myeloid cell differentiation [GO:0045637]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24753537}; Single-pass type I membrane protein {ECO:0000255}.
Q99075	reviewed	HBEGF_HUMAN	Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)]	HBEGF DTR DTS HEGFL	Homo sapiens (Human)	208	FUNCTION: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.		cell chemotaxis [GO:0060326]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB4 signaling pathway [GO:0038135]; muscle organ development [GO:0007517]; negative regulation of elastin biosynthetic process [GO:0051545]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of wound healing [GO:0090303]; regulation of heart contraction [GO:0008016]; signal transduction [GO:0007165]; wound healing, spreading of epidermal cells [GO:0035313]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; cell chemotaxis [GO:0060326]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB4 signaling pathway [GO:0038135]; muscle organ development [GO:0007517]; negative regulation of elastin biosynthetic process [GO:0051545]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of wound healing [GO:0090303]; regulation of heart contraction [GO:0008016]; signal transduction [GO:0007165]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; SUBCELLULAR LOCATION: [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein.
Q99081	reviewed	HTF4_HUMAN	Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)	TCF12 BHLHB20 HEB HTF4	Homo sapiens (Human)	682	FUNCTION: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.		cell differentiation [GO:0030154]; gene expression [GO:0010467]; immune response [GO:0006955]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gonadotropin-releasing hormone [GO:0097210]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	bHLH transcription factor binding [GO:0043425]; cAMP response element binding [GO:0035497]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; HMG box domain binding [GO:0071837]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; bHLH transcription factor binding [GO:0043425]; cAMP response element binding [GO:0035497]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; HMG box domain binding [GO:0071837]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]; cell differentiation [GO:0030154]; gene expression [GO:0010467]; immune response [GO:0006955]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gonadotropin-releasing hormone [GO:0097210]	SUBCELLULAR LOCATION: Nucleus.
Q99102	reviewed	MUC4_HUMAN	Mucin-4 (MUC-4) (Ascites sialoglycoprotein) (ASGP) (Pancreatic adenocarcinoma mucin) (Testis mucin) (Tracheobronchial mucin) [Cleaved into: Mucin-4 alpha chain (Ascites sialoglycoprotein 1) (ASGP-1); Mucin-4 beta chain (Ascites sialoglycoprotein 2) (ASGP-2)]	MUC4	Homo sapiens (Human)	5412	FUNCTION: Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces (PubMed:10880978). These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation (PubMed:10880978). Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. {ECO:0000269|PubMed:12102554, ECO:0000269|PubMed:16049287, ECO:0000269|PubMed:16814944, ECO:0000269|PubMed:16914178, ECO:0000303|PubMed:10880978}.	MISCELLANEOUS: Expression is a very useful predictor of poor prognosis in patients with invasive ductal carcinoma and intrahepatic cholangiocarcinoma, mass forming type (IDC,ICC-MF). Patients with IDC or ICC-MF who have high MUC4 expression had a worse survival rate than those with low MUC4 expression.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.; MISCELLANEOUS: [Isoform 11]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 12]: May be preferentially expressed in tumor tissues. {ECO:0000305|PubMed:10880978}.; MISCELLANEOUS: [Isoform 13]: May be preferentially expressed in tumor tissues. {ECO:0000305|PubMed:10880978}.; MISCELLANEOUS: [Isoform 15]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 16]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.; MISCELLANEOUS: [Isoform 17]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.	cell-matrix adhesion [GO:0007160]; maintenance of gastrointestinal epithelium [GO:0030277]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	ErbB-2 class receptor binding [GO:0005176]; extracellular matrix constituent, lubricant activity [GO:0030197]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; ErbB-2 class receptor binding [GO:0005176]; extracellular matrix constituent, lubricant activity [GO:0030197]; cell-matrix adhesion [GO:0007160]; maintenance of gastrointestinal epithelium [GO:0030277]	SUBCELLULAR LOCATION: [Mucin-4 beta chain]: Cell membrane {ECO:0000303|PubMed:10880978}; Single-pass membrane protein {ECO:0000303|PubMed:10880978}. Note=Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing. {ECO:0000269|PubMed:12102554, ECO:0000303|PubMed:10880978}.; SUBCELLULAR LOCATION: [Mucin-4 alpha chain]: Cell membrane {ECO:0000303|PubMed:10880978}. Secreted {ECO:0000269|PubMed:12102554}. Note=Forms a complex with Mucin-4 beta chain at the cell membrane. {ECO:0000305|PubMed:10880978}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000303|PubMed:10880978}; Single-pass membrane protein {ECO:0000303|PubMed:10880978}.; SUBCELLULAR LOCATION: [Isoform 11]: Secreted {ECO:0000303|PubMed:10880978}.; SUBCELLULAR LOCATION: [Isoform 15]: Secreted {ECO:0000303|PubMed:10880978}.; SUBCELLULAR LOCATION: [Isoform 17]: Cell membrane {ECO:0000303|PubMed:10880978}; Single-pass membrane protein {ECO:0000303|PubMed:10880978}.
Q99217	reviewed	AMELX_HUMAN	Amelogenin, X isoform	AMELX AMG AMGX	Homo sapiens (Human)	191	FUNCTION: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.		amelogenesis [GO:0097186]; biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; chondrocyte differentiation [GO:0002062]; enamel mineralization [GO:0070166]; epithelial to mesenchymal transition [GO:0001837]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of tooth mineralization [GO:0070172]; regulation of cell population proliferation [GO:0042127]; response to calcium ion [GO:0051592]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle [GO:0030139]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]	growth factor activity [GO:0008083]; hydroxyapatite binding [GO:0046848]; identical protein binding [GO:0042802]; structural constituent of tooth enamel [GO:0030345]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle [GO:0030139]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; growth factor activity [GO:0008083]; hydroxyapatite binding [GO:0046848]; identical protein binding [GO:0042802]; structural constituent of tooth enamel [GO:0030345]; amelogenesis [GO:0097186]; biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; chondrocyte differentiation [GO:0002062]; enamel mineralization [GO:0070166]; epithelial to mesenchymal transition [GO:0001837]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of tooth mineralization [GO:0070172]; regulation of cell population proliferation [GO:0042127]; response to calcium ion [GO:0051592]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:25789606}.
Q99250	reviewed	SCN2A_HUMAN	Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2)	SCN2A NAC2 SCN2A1 SCN2A2	Homo sapiens (Human)	2005	FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). {ECO:0000250|UniProtKB:B1AWN6, ECO:0000269|PubMed:1325650, ECO:0000269|PubMed:17021166, ECO:0000269|PubMed:28256214, ECO:0000269|PubMed:29844171}.		calcium ion import across plasma membrane [GO:0098703]; cellular response to hypoxia [GO:0071456]; dentate gyrus development [GO:0021542]; determination of adult lifespan [GO:0008340]; intrinsic apoptotic signaling pathway in response to osmotic stress [GO:0008627]; memory [GO:0007613]; myelination [GO:0042552]; nerve development [GO:0021675]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	axon [GO:0030424]; glutamatergic synapse [GO:0098978]; intercalated disc [GO:0014704]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; sodium channel complex [GO:0034706]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]	calmodulin binding [GO:0005516]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated sodium channel activity [GO:0005248]	axon [GO:0030424]; glutamatergic synapse [GO:0098978]; intercalated disc [GO:0014704]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; sodium channel complex [GO:0034706]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; calmodulin binding [GO:0005516]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated sodium channel activity [GO:0005248]; calcium ion import across plasma membrane [GO:0098703]; cellular response to hypoxia [GO:0071456]; dentate gyrus development [GO:0021542]; determination of adult lifespan [GO:0008340]; intrinsic apoptotic signaling pathway in response to osmotic stress [GO:0008627]; memory [GO:0007613]; myelination [GO:0042552]; nerve development [GO:0021675]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1325650}; Multi-pass membrane protein {ECO:0000269|PubMed:1325650}.
Q99259	reviewed	DCE1_HUMAN	Glutamate decarboxylase 1 (EC 4.1.1.15) (67 kDa glutamic acid decarboxylase) (GAD-67) (Glutamate decarboxylase 67 kDa isoform)	GAD1 GAD GAD67	Homo sapiens (Human)	594	FUNCTION: Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor. {ECO:0000269|PubMed:10671565, ECO:0000269|PubMed:17384644}.; FUNCTION: [Isoform 3]: Enzymatically inactive as glutamate decarboxylase. {ECO:0000269|PubMed:10671565}.		chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; glutamate catabolic process [GO:0006538]; glutamate decarboxylation to succinate [GO:0006540]; locomotory exploration behavior [GO:0035641]; neurotransmitter biosynthetic process [GO:0042136]; protein-pyridoxal-5-phosphate linkage [GO:0018352]; social behavior [GO:0035176]	axon terminus [GO:0043679]; cell cortex [GO:0005938]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; vesicle membrane [GO:0012506]	glutamate decarboxylase activity [GO:0004351]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]	axon terminus [GO:0043679]; cell cortex [GO:0005938]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; vesicle membrane [GO:0012506]; glutamate decarboxylase activity [GO:0004351]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; glutamate catabolic process [GO:0006538]; glutamate decarboxylation to succinate [GO:0006540]; locomotory exploration behavior [GO:0035641]; neurotransmitter biosynthetic process [GO:0042136]; protein-pyridoxal-5-phosphate linkage [GO:0018352]; social behavior [GO:0035176]	
Q99417	reviewed	MYCBP_HUMAN	c-Myc-binding protein (Associate of Myc 1) (AMY-1)	MYCBP AMY1	Homo sapiens (Human)	103	FUNCTION: May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.		regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion. Note=Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.
Q99418	reviewed	CYH2_HUMAN	Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)	CYTH2 ARNO PSCD2 PSCD2L	Homo sapiens (Human)	400	FUNCTION: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). {ECO:0000250|UniProtKB:P63034, ECO:0000269|PubMed:17398095}.		actin cytoskeleton organization [GO:0030036]; endocytosis [GO:0006897]; regulation of ARF protein signal transduction [GO:0032012]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; membrane [GO:0016020]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; inositol 1,4,5 trisphosphate binding [GO:0070679]; lipid binding [GO:0008289]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; membrane [GO:0016020]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; inositol 1,4,5 trisphosphate binding [GO:0070679]; lipid binding [GO:0008289]; actin cytoskeleton organization [GO:0030036]; endocytosis [GO:0006897]; regulation of ARF protein signal transduction [GO:0032012]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17398095}; Peripheral membrane protein {ECO:0000269|PubMed:17398095}. Cytoplasm {ECO:0000269|PubMed:17398095}. Cell projection {ECO:0000250|UniProtKB:P63034}. Cell projection, growth cone {ECO:0000250|UniProtKB:P63034}. Cell junction, tight junction {ECO:0000250|UniProtKB:P63034}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P63034}. Note=Both isoform 1 and isoform 2 are recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to plasma membrane (PubMed:17398095). In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas. {ECO:0000250|UniProtKB:P63034, ECO:0000269|PubMed:17398095}.
Q99424	reviewed	ACOX2_HUMAN	Peroxisomal acyl-coenzyme A oxidase 2 (EC 1.17.99.3) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase) (Trihydroxycoprostanoyl-CoA oxidase) (THCA-CoA oxidase) (THCCox)	ACOX2	Homo sapiens (Human)	681	FUNCTION: Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids (PubMed:27884763). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). {ECO:0000250|UniProtKB:P07872, ECO:0000269|PubMed:27884763}.		bile acid biosynthetic process [GO:0006699]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; lipid homeostasis [GO:0055088]; very long-chain fatty acid metabolic process [GO:0000038]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity [GO:0033791]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; palmitoyl-CoA oxidase activity [GO:0016401]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity [GO:0033791]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; palmitoyl-CoA oxidase activity [GO:0016401]; protein homodimerization activity [GO:0042803]; bile acid biosynthetic process [GO:0006699]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; lipid homeostasis [GO:0055088]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:27884763, ECO:0000269|PubMed:8943006}.
Q99426	reviewed	TBCB_HUMAN	Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B)	TBCB CG22 CKAP1	Homo sapiens (Human)	244	FUNCTION: Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}.		cell differentiation [GO:0030154]; cytoplasmic microtubule organization [GO:0031122]; nervous system development [GO:0007399]; post-chaperonin tubulin folding pathway [GO:0007023]; tubulin complex assembly [GO:0007021]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]	alpha-tubulin binding [GO:0043014]; microtubule plus-end binding [GO:0051010]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]; alpha-tubulin binding [GO:0043014]; microtubule plus-end binding [GO:0051010]; cell differentiation [GO:0030154]; cytoplasmic microtubule organization [GO:0031122]; nervous system development [GO:0007399]; post-chaperonin tubulin folding pathway [GO:0007023]; tubulin complex assembly [GO:0007021]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:22777741}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15831477}. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone. {ECO:0000269|PubMed:15831477}.
Q99435	reviewed	NELL2_HUMAN	Protein kinase C-binding protein NELL2 (NEL-like protein 2) (Nel-related protein 2)	NELL2 NRP2	Homo sapiens (Human)	816	FUNCTION: Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity). {ECO:0000250|UniProtKB:Q62918}.		fertilization [GO:0009566]; neuron cellular homeostasis [GO:0070050]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; protein kinase C binding [GO:0005080]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; protein kinase C binding [GO:0005080]; fertilization [GO:0009566]; neuron cellular homeostasis [GO:0070050]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q62918}.
Q99436	reviewed	PSB7_HUMAN	Proteasome subunit beta type-7 (EC 3.4.25.1) (Macropain chain Z) (Multicatalytic endopeptidase complex chain Z) (Proteasome subunit Z)	PSMB7 Z	Homo sapiens (Human)	277	FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity. {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.		proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; secretory granule lumen [GO:0034774]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; secretory granule lumen [GO:0034774]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:18549262, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:18549262, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
Q99437	reviewed	VATO_HUMAN	V-type proton ATPase 21 kDa proteolipid subunit c'' (V-ATPase 21 kDa proteolipid subunit c'') (Vacuolar proton pump 21 kDa proteolipid subunit c'') (hATPL)	ATP6V0B ATP6F	Homo sapiens (Human)	205	FUNCTION: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). {ECO:0000250|UniProtKB:Q2TA24, ECO:0000269|PubMed:33065002}.		endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; vacuolar acidification [GO:0007035]	clathrin-coated vesicle membrane [GO:0030665]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	proton-transporting ATPase activity, rotational mechanism [GO:0046961]	clathrin-coated vesicle membrane [GO:0030665]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q2TA24}; Multi-pass membrane protein {ECO:0000255}.
Q99439	reviewed	CNN2_HUMAN	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)	CNN2	Homo sapiens (Human)	309	FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.		actin filament organization [GO:0007015]; actomyosin structure organization [GO:0031032]; cellular response to mechanical stimulus [GO:0071260]; cytoskeleton organization [GO:0007010]; establishment of localization in cell [GO:0051649]; hemopoiesis [GO:0030097]; macrophage migration [GO:1905517]; negative regulation of macrophage migration [GO:1905522]; negative regulation of phagocytosis [GO:0050765]; phagocytosis [GO:0006909]; positive regulation of gene expression [GO:0010628]; regulation of actin filament-based process [GO:0032970]; regulation of leukocyte proliferation [GO:0070663]; wound healing [GO:0042060]	actin cytoskeleton [GO:0015629]; cell-cell junction [GO:0005911]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; specific granule lumen [GO:0035580]; stress fiber [GO:0001725]; tertiary granule lumen [GO:1904724]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]	actin cytoskeleton [GO:0015629]; cell-cell junction [GO:0005911]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; specific granule lumen [GO:0035580]; stress fiber [GO:0001725]; tertiary granule lumen [GO:1904724]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; actin filament organization [GO:0007015]; actomyosin structure organization [GO:0031032]; cellular response to mechanical stimulus [GO:0071260]; cytoskeleton organization [GO:0007010]; establishment of localization in cell [GO:0051649]; hemopoiesis [GO:0030097]; macrophage migration [GO:1905517]; negative regulation of macrophage migration [GO:1905522]; negative regulation of phagocytosis [GO:0050765]; phagocytosis [GO:0006909]; positive regulation of gene expression [GO:0010628]; regulation of actin filament-based process [GO:0032970]; regulation of leukocyte proliferation [GO:0070663]; wound healing [GO:0042060]	
Q99447	reviewed	PCY2_HUMAN	Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase)	PCYT2	Homo sapiens (Human)	389	FUNCTION: Ethanolamine-phosphate cytidylyltransferase that catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway (PubMed:9083101, PubMed:31637422). Phosphatidylethanolamine is a dominant inner-leaflet phospholipid in cell membranes, where it plays a role in membrane function by structurally stabilizing membrane-anchored proteins, and participates in important cellular processes such as cell division, cell fusion, blood coagulation, and apoptosis (PubMed:9083101). {ECO:0000269|PubMed:31637422, ECO:0000269|PubMed:9083101, ECO:0000303|PubMed:9083101}.		phosphatidylethanolamine biosynthetic process [GO:0006646]; phospholipid biosynthetic process [GO:0008654]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	ethanolamine-phosphate cytidylyltransferase activity [GO:0004306]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; ethanolamine-phosphate cytidylyltransferase activity [GO:0004306]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phospholipid biosynthetic process [GO:0008654]	
Q99453	reviewed	PHX2B_HUMAN	Paired mesoderm homeobox protein 2B (Neuroblastoma Phox) (NBPhox) (PHOX2B homeodomain protein) (Paired-like homeobox 2B)	PHOX2B PMX2B	Homo sapiens (Human)	314	FUNCTION: Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.		autonomic nervous system development [GO:0048483]; brainstem development [GO:0003360]; cell differentiation in hindbrain [GO:0021533]; cellular response to BMP stimulus [GO:0071773]; cellular response to carbon dioxide [GO:0071244]; dopaminergic neuron differentiation [GO:0071542]; efferent axon development in a lateral line nerve [GO:0048894]; enteric nervous system development [GO:0048484]; glial cell differentiation [GO:0010001]; hindbrain tangential cell migration [GO:0021934]; inner ear development [GO:0048839]; medullary reticular formation development [GO:0021723]; membrane depolarization [GO:0051899]; motor neuron migration [GO:0097475]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of type B pancreatic cell proliferation [GO:1904691]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; noradrenergic neuron development [GO:0003358]; noradrenergic neuron differentiation [GO:0003357]; parasympathetic nervous system development [GO:0048486]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory system development [GO:0060541]; response to activity [GO:0014823]; retrotrapezoid nucleus neuron differentiation [GO:0061452]; skeletal muscle cell differentiation [GO:0035914]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]; type B pancreatic cell proliferation [GO:0044342]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; autonomic nervous system development [GO:0048483]; brainstem development [GO:0003360]; cell differentiation in hindbrain [GO:0021533]; cellular response to BMP stimulus [GO:0071773]; cellular response to carbon dioxide [GO:0071244]; dopaminergic neuron differentiation [GO:0071542]; efferent axon development in a lateral line nerve [GO:0048894]; enteric nervous system development [GO:0048484]; glial cell differentiation [GO:0010001]; hindbrain tangential cell migration [GO:0021934]; inner ear development [GO:0048839]; medullary reticular formation development [GO:0021723]; membrane depolarization [GO:0051899]; motor neuron migration [GO:0097475]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of type B pancreatic cell proliferation [GO:1904691]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; noradrenergic neuron development [GO:0003358]; noradrenergic neuron differentiation [GO:0003357]; parasympathetic nervous system development [GO:0048486]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory system development [GO:0060541]; response to activity [GO:0014823]; retrotrapezoid nucleus neuron differentiation [GO:0061452]; skeletal muscle cell differentiation [GO:0035914]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q99456	reviewed	K1C12_HUMAN	Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12)	KRT12	Homo sapiens (Human)	494	FUNCTION: Involved in corneal epithelium organization, integrity and corneal keratin expression. {ECO:0000269|PubMed:26758872}.	MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	cornea development in camera-type eye [GO:0061303]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; morphogenesis of an epithelium [GO:0002009]; visual perception [GO:0007601]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; cornea development in camera-type eye [GO:0061303]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; morphogenesis of an epithelium [GO:0002009]; visual perception [GO:0007601]	
Q99459	reviewed	CDC5L_HUMAN	Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein)	CDC5L KIAA0432 PCDC5RP	Homo sapiens (Human)	802	FUNCTION: DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}.		cell cycle [GO:0007049]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; WD40-repeat domain binding [GO:0071987]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; WD40-repeat domain binding [GO:0071987]; cell cycle [GO:0007049]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9598309}. Nucleus speckle {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:10827081, ECO:0000269|PubMed:11544257}. Cytoplasm {ECO:0000269|PubMed:9038199}. Note=May shuttle between cytoplasm and nucleus. {ECO:0000269|PubMed:9038199}.
Q99460	reviewed	PSMD1_HUMAN	26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)	PSMD1	Homo sapiens (Human)	953	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, base subcomplex [GO:0008540]; proteasome storage granule [GO:0034515]	enzyme regulator activity [GO:0030234]; ubiquitin protein ligase binding [GO:0031625]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, base subcomplex [GO:0008540]; proteasome storage granule [GO:0034515]; enzyme regulator activity [GO:0030234]; ubiquitin protein ligase binding [GO:0031625]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176]	
Q99466	reviewed	NOTC4_HUMAN	Neurogenic locus notch homolog protein 4 (Notch 4) (hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain]	NOTCH4 INT3	Homo sapiens (Human)	2003	FUNCTION: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). {ECO:0000250}.		branching involved in blood vessel morphogenesis [GO:0001569]; cell differentiation [GO:0030154]; cell fate determination [GO:0001709]; epithelial to mesenchymal transition [GO:0001837]; hemopoiesis [GO:0030097]; mammary gland development [GO:0030879]; morphogenesis of a branching structure [GO:0001763]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription of Notch receptor target [GO:0007221]; vasculature development [GO:0001944]; wound healing [GO:0042060]	cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; signaling receptor activity [GO:0038023]; branching involved in blood vessel morphogenesis [GO:0001569]; cell differentiation [GO:0030154]; cell fate determination [GO:0001709]; epithelial to mesenchymal transition [GO:0001837]; hemopoiesis [GO:0030097]; mammary gland development [GO:0030879]; morphogenesis of a branching structure [GO:0001763]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription of Notch receptor target [GO:0007221]; vasculature development [GO:0001944]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Notch 4 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.
Q99467	reviewed	CD180_HUMAN	CD180 antigen (Lymphocyte antigen 64) (Radioprotective 105 kDa protein) (CD antigen CD180)	CD180 LY64 RP105	Homo sapiens (Human)	661	FUNCTION: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). {ECO:0000250}.		B cell proliferation involved in immune response [GO:0002322]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; B cell proliferation involved in immune response [GO:0002322]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q99469	reviewed	STAC_HUMAN	SH3 and cysteine-rich domain-containing protein (Src homology 3 and cysteine-rich domain-containing protein)	STAC STAC1	Homo sapiens (Human)	402	FUNCTION: Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:P97306}.		cellular response to heat [GO:0034605]; positive regulation of cation channel activity [GO:2001259]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; signal transduction [GO:0007165]; skeletal muscle contraction [GO:0003009]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; T-tubule [GO:0030315]	metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; T-tubule [GO:0030315]; metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]; cellular response to heat [GO:0034605]; positive regulation of cation channel activity [GO:2001259]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; signal transduction [GO:0007165]; skeletal muscle contraction [GO:0003009]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P97306}. Cell membrane {ECO:0000250|UniProtKB:P97306}; Peripheral membrane protein {ECO:0000250|UniProtKB:P97306}; Cytoplasmic side {ECO:0000250|UniProtKB:P97306}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P97306}; Peripheral membrane protein {ECO:0000250|UniProtKB:P97306}; Cytoplasmic side {ECO:0000250|UniProtKB:P97306}.
Q99471	reviewed	PFD5_HUMAN	Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1)	PFDN5 MM1 PFD5	Homo sapiens (Human)	154	FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. {ECO:0000269|PubMed:9630229}.	MISCELLANEOUS: [Isoform 2]: Does not repress transcription activity of MYC. {ECO:0000305}.	chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; protein folding [GO:0006457]; regulation of DNA-templated transcription [GO:0006355]; retina development in camera-type eye [GO:0060041]; RNA polymerase I assembly [GO:1990113]; RNA polymerase II core complex assembly [GO:1990114]; RNA polymerase III assembly [GO:1990115]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]	amyloid-beta binding [GO:0001540]; transcription corepressor activity [GO:0003714]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]; amyloid-beta binding [GO:0001540]; transcription corepressor activity [GO:0003714]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; protein folding [GO:0006457]; regulation of DNA-templated transcription [GO:0006355]; retina development in camera-type eye [GO:0060041]; RNA polymerase I assembly [GO:1990113]; RNA polymerase II core complex assembly [GO:1990114]; RNA polymerase III assembly [GO:1990115]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus.
Q99487	reviewed	PAFA2_HUMAN	Platelet-activating factor acetylhydrolase 2, cytoplasmic (EC 3.1.1.47) (PAF:lysophospholipid transacetylase) (PAF:sphingosine transacetylase) (Platelet-activating factor acetyltransferase PAFAH2) (EC 2.3.1.149) (Serine-dependent phospholipase A2) (SD-PLA2) (hSD-PLA2)	PAFAH2	Homo sapiens (Human)	392	FUNCTION: Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:9494101). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity). {ECO:0000250|UniProtKB:P79106, ECO:0000250|UniProtKB:P83006, ECO:0000269|PubMed:9494101}.		blood coagulation [GO:0007596]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; phospholipid binding [GO:0005543]; platelet-activating factor acetyltransferase activity [GO:0047179]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; phospholipid binding [GO:0005543]; platelet-activating factor acetyltransferase activity [GO:0047179]; blood coagulation [GO:0007596]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9494101}. Membrane {ECO:0000250|UniProtKB:P79106}; Lipid-anchor {ECO:0000250|UniProtKB:P79106}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P79106}; Lipid-anchor {ECO:0000250|UniProtKB:P79106}. Note=In resting cells, localizes to intracellular membranes and cytoplasm. Translocates from the cytoplasm to intracellular membranes upon oxidative stress. {ECO:0000250|UniProtKB:P79106}.
Q99489	reviewed	OXDD_HUMAN	D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1)	DDO	Homo sapiens (Human)	341	FUNCTION: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate. {ECO:0000269|PubMed:9163533}.		aspartate catabolic process [GO:0006533]; D-amino acid catabolic process [GO:0019478]; grooming behavior [GO:0007625]; hormone metabolic process [GO:0042445]; insemination [GO:0007320]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	D-aspartate oxidase activity [GO:0008445]; FAD binding [GO:0071949]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; D-aspartate oxidase activity [GO:0008445]; FAD binding [GO:0071949]; aspartate catabolic process [GO:0006533]; D-amino acid catabolic process [GO:0019478]; grooming behavior [GO:0007625]; hormone metabolic process [GO:0042445]; insemination [GO:0007320]	SUBCELLULAR LOCATION: Peroxisome.
Q99490	reviewed	AGAP2_HUMAN	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE)	AGAP2 CENTG1 KIAA0167	Homo sapiens (Human)	1192	FUNCTION: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}.		actin cytoskeleton organization [GO:0030036]; endosomal transport [GO:0016197]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of 1-phosphatidylinositol-3-kinase activity [GO:0061903]; positive regulation of protein kinase activity [GO:0045860]; protein transport [GO:0015031]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; actin cytoskeleton organization [GO:0030036]; endosomal transport [GO:0016197]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of 1-phosphatidylinositol-3-kinase activity [GO:0061903]; positive regulation of protein kinase activity [GO:0045860]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Q99496	reviewed	RING2_HUMAN	E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)	RNF2 BAP1 DING HIPI3 RING1B	Homo sapiens (Human)	336	FUNCTION: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:33864376, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity). Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (By similarity). {ECO:0000250|UniProtKB:Q9CQJ4, ECO:0000269|PubMed:11513855, ECO:0000269|PubMed:15386022, ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:20696397, ECO:0000269|PubMed:21772249, ECO:0000269|PubMed:25355358, ECO:0000269|PubMed:25519132, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:33864376, ECO:0000305}.	MISCELLANEOUS: The hPRC-H complex purification reported probably presents a mixture of different PRC1-like complexes. {ECO:0000269|PubMed:12167701}.	anterior/posterior axis specification [GO:0009948]; chromatin remodeling [GO:0006338]; epigenetic regulation of gene expression [GO:0040029]; gastrulation with mouth forming second [GO:0001702]; gene expression [GO:0010467]; germ cell development [GO:0007281]; mitotic cell cycle [GO:0000278]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; euchromatin [GO:0000791]; MLL1 complex [GO:0071339]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]; ubiquitin ligase complex [GO:0000151]	chromatin binding [GO:0003682]; histone H2AK119 ubiquitin ligase activity [GO:0140862]; RING-like zinc finger domain binding [GO:0071535]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; euchromatin [GO:0000791]; MLL1 complex [GO:0071339]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]; ubiquitin ligase complex [GO:0000151]; chromatin binding [GO:0003682]; histone H2AK119 ubiquitin ligase activity [GO:0140862]; RING-like zinc finger domain binding [GO:0071535]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; anterior/posterior axis specification [GO:0009948]; chromatin remodeling [GO:0006338]; epigenetic regulation of gene expression [GO:0040029]; gastrulation with mouth forming second [GO:0001702]; gene expression [GO:0010467]; germ cell development [GO:0007281]; mitotic cell cycle [GO:0000278]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530}. Cytoplasm {ECO:0000250|UniProtKB:Q9CQJ4}. Chromosome {ECO:0000250|UniProtKB:Q9CQJ4}. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells. {ECO:0000250|UniProtKB:Q9CQJ4}.
Q99497	reviewed	PARK7_HUMAN	Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124)	PARK7	Homo sapiens (Human)	189	FUNCTION: Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785, PubMed:26995087, PubMed:28993701). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). But this function is rebuted by other works (PubMed:27903648, PubMed:31653696). As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:28013050, PubMed:26995087). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin (PubMed:30150385). Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels (PubMed:30150385, PubMed:30894531). Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed:22523093, PubMed:31653696, PubMed:28993701). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). {ECO:0000250|UniProtKB:Q99LX0, ECO:0000269|PubMed:11477070, ECO:0000269|PubMed:12612053, ECO:0000269|PubMed:12855764, ECO:0000269|PubMed:12939276, ECO:0000269|PubMed:14749723, ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:15502874, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:17015834, ECO:0000269|PubMed:18626009, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20186336, ECO:0000269|PubMed:20304780, ECO:0000269|PubMed:21097510, ECO:0000269|PubMed:22523093, ECO:0000269|PubMed:23792957, ECO:0000269|PubMed:23847046, ECO:0000269|PubMed:25416785, ECO:0000269|PubMed:26995087, ECO:0000269|PubMed:28013050, ECO:0000269|PubMed:28596309, ECO:0000269|PubMed:28993701, ECO:0000269|PubMed:30150385, ECO:0000269|PubMed:30894531, ECO:0000269|PubMed:9070310}.		activation of protein kinase B activity [GO:0032148]; adult locomotory behavior [GO:0008344]; autophagy [GO:0006914]; cellular detoxification of aldehyde [GO:0110095]; cellular detoxification of methylglyoxal [GO:0140041]; cellular response to glyoxal [GO:0036471]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to oxidative stress [GO:0034599]; detection of oxidative stress [GO:0070994]; detoxification of copper ion [GO:0010273]; detoxification of hydrogen peroxide [GO:0061691]; detoxification of mercury ion [GO:0050787]; DNA repair [GO:0006281]; dopamine uptake involved in synaptic transmission [GO:0051583]; glucose homeostasis [GO:0042593]; glutathione deglycation [GO:0036531]; glycolate biosynthetic process [GO:0046295]; glyoxal metabolic process [GO:1903189]; guanine deglycation [GO:0106044]; guanine deglycation, glyoxal removal [GO:0106046]; guanine deglycation, methylglyoxal removal [GO:0106045]; hydrogen peroxide metabolic process [GO:0042743]; inflammatory response [GO:0006954]; insulin secretion [GO:0030073]; lactate biosynthetic process [GO:0019249]; membrane depolarization [GO:0051899]; membrane hyperpolarization [GO:0060081]; methylglyoxal catabolic process to lactate [GO:0061727]; methylglyoxal metabolic process [GO:0009438]; mitochondrion organization [GO:0007005]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]; negative regulation of death-inducing signaling complex assembly [GO:1903073]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway [GO:1905259]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein binding [GO:0032091]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of protein K48-linked deubiquitination [GO:1903094]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of TRAIL-activated apoptotic signaling pathway [GO:1903122]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; negative regulation of ubiquitin-specific protease activity [GO:2000157]; peptidyl-arginine deglycation [GO:0036527]; peptidyl-cysteine deglycation [GO:0036526]; peptidyl-lysine deglycation [GO:0036528]; positive regulation of acute inflammatory response to antigenic stimulus [GO:0002866]; positive regulation of androgen receptor activity [GO:2000825]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of dopamine biosynthetic process [GO:1903181]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of L-dopa biosynthetic process [GO:1903197]; positive regulation of L-dopa decarboxylase activity [GO:1903200]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]; positive regulation of NAD(P)H oxidase activity [GO:0033864]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of pyrroline-5-carboxylate reductase activity [GO:1903168]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of superoxide dismutase activity [GO:1901671]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of tyrosine 3-monooxygenase activity [GO:1903178]; protein deglycation, glyoxal removal [GO:0036529]; protein deglycation, methylglyoxal removal [GO:0036530]; protein deglycosylation [GO:0006517]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; Ras protein signal transduction [GO:0007265]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of inflammatory response [GO:0050727]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of neuron apoptotic process [GO:0043523]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376]; regulation of supramolecular fiber organization [GO:1902903]; response to oxidative stress [GO:0006979]; single fertilization [GO:0007338]	adherens junction [GO:0005912]; axon [GO:0030424]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; PML body [GO:0016605]; presynapse [GO:0098793]	cadherin binding [GO:0045296]; copper ion binding [GO:0005507]; cupric ion binding [GO:1903135]; cuprous ion binding [GO:1903136]; cytokine binding [GO:0019955]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; glyoxalase (glycolic acid-forming) activity [GO:1990422]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; L-dopa decarboxylase activator activity [GO:0036478]; mercury ion binding [GO:0045340]; mRNA binding [GO:0003729]; nuclear androgen receptor binding [GO:0050681]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; oxygen sensor activity [GO:0019826]; peptidase activity [GO:0008233]; peroxiredoxin activity [GO:0051920]; protein deglycase activity [GO:0036524]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; small protein activating enzyme binding [GO:0044388]; superoxide dismutase copper chaperone activity [GO:0016532]; transcription coactivator activity [GO:0003713]; tyrosine 3-monooxygenase activator activity [GO:0036470]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; ubiquitin-specific protease binding [GO:1990381]	adherens junction [GO:0005912]; axon [GO:0030424]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; PML body [GO:0016605]; presynapse [GO:0098793]; cadherin binding [GO:0045296]; copper ion binding [GO:0005507]; cupric ion binding [GO:1903135]; cuprous ion binding [GO:1903136]; cytokine binding [GO:0019955]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; glyoxalase (glycolic acid-forming) activity [GO:1990422]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; L-dopa decarboxylase activator activity [GO:0036478]; mercury ion binding [GO:0045340]; mRNA binding [GO:0003729]; nuclear androgen receptor binding [GO:0050681]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; oxygen sensor activity [GO:0019826]; peptidase activity [GO:0008233]; peroxiredoxin activity [GO:0051920]; protein deglycase activity [GO:0036524]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; small protein activating enzyme binding [GO:0044388]; superoxide dismutase copper chaperone activity [GO:0016532]; transcription coactivator activity [GO:0003713]; tyrosine 3-monooxygenase activator activity [GO:0036470]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; ubiquitin-specific protease binding [GO:1990381]; activation of protein kinase B activity [GO:0032148]; adult locomotory behavior [GO:0008344]; autophagy [GO:0006914]; cellular detoxification of aldehyde [GO:0110095]; cellular detoxification of methylglyoxal [GO:0140041]; cellular response to glyoxal [GO:0036471]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to oxidative stress [GO:0034599]; detection of oxidative stress [GO:0070994]; detoxification of copper ion [GO:0010273]; detoxification of hydrogen peroxide [GO:0061691]; detoxification of mercury ion [GO:0050787]; DNA repair [GO:0006281]; dopamine uptake involved in synaptic transmission [GO:0051583]; glucose homeostasis [GO:0042593]; glutathione deglycation [GO:0036531]; glycolate biosynthetic process [GO:0046295]; glyoxal metabolic process [GO:1903189]; guanine deglycation [GO:0106044]; guanine deglycation, glyoxal removal [GO:0106046]; guanine deglycation, methylglyoxal removal [GO:0106045]; hydrogen peroxide metabolic process [GO:0042743]; inflammatory response [GO:0006954]; insulin secretion [GO:0030073]; lactate biosynthetic process [GO:0019249]; membrane depolarization [GO:0051899]; membrane hyperpolarization [GO:0060081]; methylglyoxal catabolic process to lactate [GO:0061727]; methylglyoxal metabolic process [GO:0009438]; mitochondrion organization [GO:0007005]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]; negative regulation of death-inducing signaling complex assembly [GO:1903073]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway [GO:1905259]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein binding [GO:0032091]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of protein K48-linked deubiquitination [GO:1903094]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of TRAIL-activated apoptotic signaling pathway [GO:1903122]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; negative regulation of ubiquitin-specific protease activity [GO:2000157]; peptidyl-arginine deglycation [GO:0036527]; peptidyl-cysteine deglycation [GO:0036526]; peptidyl-lysine deglycation [GO:0036528]; positive regulation of acute inflammatory response to antigenic stimulus [GO:0002866]; positive regulation of androgen receptor activity [GO:2000825]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of dopamine biosynthetic process [GO:1903181]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of L-dopa biosynthetic process [GO:1903197]; positive regulation of L-dopa decarboxylase activity [GO:1903200]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]; positive regulation of NAD(P)H oxidase activity [GO:0033864]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of pyrroline-5-carboxylate reductase activity [GO:1903168]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of superoxide dismutase activity [GO:1901671]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of tyrosine 3-monooxygenase activity [GO:1903178]; protein deglycation, glyoxal removal [GO:0036529]; protein deglycation, methylglyoxal removal [GO:0036530]; protein deglycosylation [GO:0006517]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; Ras protein signal transduction [GO:0007265]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of inflammatory response [GO:0050727]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of neuron apoptotic process [GO:0043523]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376]; regulation of supramolecular fiber organization [GO:1902903]; response to oxidative stress [GO:0006979]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q99LX0}; Lipid-anchor {ECO:0000250|UniProtKB:Q99LX0}. Cytoplasm {ECO:0000269|PubMed:12851414, ECO:0000269|PubMed:14579415, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:28596309}. Nucleus {ECO:0000269|PubMed:12851414, ECO:0000269|PubMed:14579415, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:28596309}. Membrane raft {ECO:0000250|UniProtKB:O88767}. Mitochondrion {ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:31536960}. Endoplasmic reticulum {ECO:0000269|PubMed:31536960}. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (PubMed:18711745). Detected in tau inclusions in brains from neurodegenerative disease patients (PubMed:14705119). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation. {ECO:0000269|PubMed:14705119, ECO:0000269|PubMed:18711745}.
Q99500	reviewed	S1PR3_HUMAN	Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3)	S1PR3 C9orf108 C9orf47 EDG3	Homo sapiens (Human)	378	FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. {ECO:0000269|PubMed:10617617}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; anatomical structure morphogenesis [GO:0009653]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of establishment of endothelial barrier [GO:1903141]; Notch signaling pathway [GO:0007219]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of interleukin-1 beta production [GO:0032651]; regulation of metabolic process [GO:0019222]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; integrin binding [GO:0005178]; lipid binding [GO:0008289]; sphingosine-1-phosphate receptor activity [GO:0038036]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; integrin binding [GO:0005178]; lipid binding [GO:0008289]; sphingosine-1-phosphate receptor activity [GO:0038036]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; anatomical structure morphogenesis [GO:0009653]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of establishment of endothelial barrier [GO:1903141]; Notch signaling pathway [GO:0007219]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of interleukin-1 beta production [GO:0032651]; regulation of metabolic process [GO:0019222]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q99501	reviewed	GA2L1_HUMAN	GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1)	GAS2L1 GAR22	Homo sapiens (Human)	681	FUNCTION: Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}.		actin crosslink formation [GO:0051764]; cellular response to starvation [GO:0009267]; cellular response to thyroid hormone stimulus [GO:0097067]; microtubule bundle formation [GO:0001578]; negative regulation of cell growth [GO:0030308]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of gene expression [GO:0010629]; negative regulation of microtubule depolymerization [GO:0007026]; protein localization to microtubule plus-end [GO:1904825]; regulation of cell cycle [GO:0051726]; regulation of microtubule polymerization or depolymerization [GO:0031110]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017]; nuclear thyroid hormone receptor binding [GO:0046966]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017]; nuclear thyroid hormone receptor binding [GO:0046966]; actin crosslink formation [GO:0051764]; cellular response to starvation [GO:0009267]; cellular response to thyroid hormone stimulus [GO:0097067]; microtubule bundle formation [GO:0001578]; negative regulation of cell growth [GO:0030308]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of gene expression [GO:0010629]; negative regulation of microtubule depolymerization [GO:0007026]; protein localization to microtubule plus-end [GO:1904825]; regulation of cell cycle [GO:0051726]; regulation of microtubule polymerization or depolymerization [GO:0031110]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24706950}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:24706950}. Note=Colocalizes with the tips of microtubule plus ends. {ECO:0000269|PubMed:24706950}.
Q99502	reviewed	EYA1_HUMAN	Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48)	EYA1	Homo sapiens (Human)	592	FUNCTION: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity). {ECO:0000250|UniProtKB:P97767, ECO:0000269|PubMed:19234442}.		anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; aorta morphogenesis [GO:0035909]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell differentiation [GO:0030154]; cochlea morphogenesis [GO:0090103]; double-strand break repair [GO:0006302]; embryonic skeletal system morphogenesis [GO:0048704]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; mesodermal cell fate specification [GO:0007501]; metanephros development [GO:0001656]; middle ear morphogenesis [GO:0042474]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; neuron fate specification [GO:0048665]; otic vesicle morphogenesis [GO:0071600]; outer ear morphogenesis [GO:0042473]; outflow tract morphogenesis [GO:0003151]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of DNA repair [GO:0045739]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]; regulation of neuron differentiation [GO:0045664]; response to ionizing radiation [GO:0010212]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; striated muscle tissue development [GO:0014706]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]	histone H2AXY142 phosphatase activity [GO:0140793]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein tyrosine phosphatase activity [GO:0004725]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; histone H2AXY142 phosphatase activity [GO:0140793]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein tyrosine phosphatase activity [GO:0004725]; RNA binding [GO:0003723]; anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; aorta morphogenesis [GO:0035909]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell differentiation [GO:0030154]; cochlea morphogenesis [GO:0090103]; double-strand break repair [GO:0006302]; embryonic skeletal system morphogenesis [GO:0048704]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; mesodermal cell fate specification [GO:0007501]; metanephros development [GO:0001656]; middle ear morphogenesis [GO:0042474]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; neuron fate specification [GO:0048665]; otic vesicle morphogenesis [GO:0071600]; outer ear morphogenesis [GO:0042473]; outflow tract morphogenesis [GO:0003151]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of DNA repair [GO:0045739]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]; regulation of neuron differentiation [GO:0045664]; response to ionizing radiation [GO:0010212]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; striated muscle tissue development [GO:0014706]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12500905}. Nucleus {ECO:0000269|PubMed:12500905, ECO:0000269|PubMed:19234442}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000269|PubMed:19234442}.
Q99504	reviewed	EYA3_HUMAN	Eyes absent homolog 3 (EC 3.1.3.48)	EYA3	Homo sapiens (Human)	573	FUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}.		anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; double-strand break repair [GO:0006302]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212]; visual perception [GO:0007601]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone H2AXY142 phosphatase activity [GO:0140793]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone H2AXY142 phosphatase activity [GO:0140793]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725]; anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; double-strand break repair [GO:0006302]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P97480}. Nucleus {ECO:0000269|PubMed:19234442}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:19234442). With decreasing efficiency, translocalized to the nucleus by SIX2 and SIX5, and SIX4, respectively (By similarity). {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442}.
Q99518	reviewed	FMO2_HUMAN	Flavin-containing monooxygenase 2 (EC 1.14.13.-) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2)	FMO2	Homo sapiens (Human)	535	FUNCTION: Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation (PubMed:9804831, PubMed:15294458, PubMed:15144220, PubMed:18948378, PubMed:18930751). Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid (PubMed:9804831, PubMed:15144220). In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate (PubMed:18948378, PubMed:18930751). Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton (PubMed:15294458). {ECO:0000269|PubMed:15144220, ECO:0000269|PubMed:15294458, ECO:0000269|PubMed:18930751, ECO:0000269|PubMed:18948378, ECO:0000269|PubMed:9804831}.		energy homeostasis [GO:0097009]; NADP metabolic process [GO:0006739]; NADPH oxidation [GO:0070995]; negative regulation of fatty acid oxidation [GO:0046322]; organic acid metabolic process [GO:0006082]; oxygen metabolic process [GO:0072592]; toxin metabolic process [GO:0009404]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; energy homeostasis [GO:0097009]; NADP metabolic process [GO:0006739]; NADPH oxidation [GO:0070995]; negative regulation of fatty acid oxidation [GO:0046322]; organic acid metabolic process [GO:0006082]; oxygen metabolic process [GO:0072592]; toxin metabolic process [GO:0009404]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:P17635}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P17635}; Single-pass membrane protein {ECO:0000255}.
Q99519	reviewed	NEUR1_HUMAN	Sialidase-1 (EC 3.2.1.18) (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1)	NEU1 NANH	Homo sapiens (Human)	415	FUNCTION: Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:25153125, ECO:0000269|PubMed:8985184}.		ganglioside catabolic process [GO:0006689]; oligosaccharide catabolic process [GO:0009313]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]	alpha-sialidase activity [GO:0016997]; exo-alpha-(2->3)-sialidase activity [GO:0052794]; exo-alpha-(2->6)-sialidase activity [GO:0052795]; exo-alpha-(2->8)-sialidase activity [GO:0052796]; exo-alpha-sialidase activity [GO:0004308]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; alpha-sialidase activity [GO:0016997]; exo-alpha-(2->3)-sialidase activity [GO:0052794]; exo-alpha-(2->6)-sialidase activity [GO:0052795]; exo-alpha-(2->8)-sialidase activity [GO:0052796]; exo-alpha-sialidase activity [GO:0004308]; ganglioside catabolic process [GO:0006689]; oligosaccharide catabolic process [GO:0009313]	SUBCELLULAR LOCATION: Lysosome membrane; Peripheral membrane protein; Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Lysosome {ECO:0000269|PubMed:25153125}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
Q99523	reviewed	SORT_HUMAN	Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)	SORT1	Homo sapiens (Human)	831	FUNCTION: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:16787399). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. {ECO:0000269|PubMed:10085125, ECO:0000269|PubMed:11331584, ECO:0000269|PubMed:11390366, ECO:0000269|PubMed:12209882, ECO:0000269|PubMed:12598608, ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:14985763, ECO:0000269|PubMed:15313463, ECO:0000269|PubMed:15930396, ECO:0000269|PubMed:15987945, ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:18817523}.		endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endosome transport via multivesicular body sorting pathway [GO:0032509]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose import [GO:0046323]; Golgi to endosome transport [GO:0006895]; Golgi to lysosome transport [GO:0090160]; maintenance of synapse structure [GO:0099558]; myotube differentiation [GO:0014902]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of lipoprotein lipase activity [GO:0051005]; neuropeptide signaling pathway [GO:0007218]; neurotrophin TRK receptor signaling pathway [GO:0048011]; ossification [GO:0001503]; plasma membrane to endosome transport [GO:0048227]; protein targeting to lysosome [GO:0006622]; regulation of gene expression [GO:0010468]; response to insulin [GO:0032868]; vesicle organization [GO:0016050]	cell surface [GO:0009986]; cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network transport vesicle [GO:0030140]	enzyme binding [GO:0019899]; nerve growth factor binding [GO:0048406]; nerve growth factor receptor activity [GO:0010465]; neurotensin receptor activity, non-G protein-coupled [GO:0030379]; retromer complex binding [GO:1905394]	cell surface [GO:0009986]; cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network transport vesicle [GO:0030140]; enzyme binding [GO:0019899]; nerve growth factor binding [GO:0048406]; nerve growth factor receptor activity [GO:0010465]; neurotensin receptor activity, non-G protein-coupled [GO:0030379]; retromer complex binding [GO:1905394]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endosome transport via multivesicular body sorting pathway [GO:0032509]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose import [GO:0046323]; Golgi to endosome transport [GO:0006895]; Golgi to lysosome transport [GO:0090160]; maintenance of synapse structure [GO:0099558]; myotube differentiation [GO:0014902]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of lipoprotein lipase activity [GO:0051005]; neuropeptide signaling pathway [GO:0007218]; neurotrophin TRK receptor signaling pathway [GO:0048011]; ossification [GO:0001503]; plasma membrane to endosome transport [GO:0048227]; protein targeting to lysosome [GO:0006622]; regulation of gene expression [GO:0010468]; response to insulin [GO:0032868]; vesicle organization [GO:0016050]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:18817523}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:18817523}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin.
Q99527	reviewed	GPER1_HUMAN	G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER)	GPER1 CEPR CMKRL2 DRY12 GPER GPR30	Homo sapiens (Human)	375	FUNCTION: G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells. {ECO:0000269|PubMed:11043579, ECO:0000269|PubMed:15539556, ECO:0000269|PubMed:15705806, ECO:0000269|PubMed:19179659, ECO:0000269|PubMed:19342448, ECO:0000269|PubMed:20203690, ECO:0000269|PubMed:20551055, ECO:0000269|PubMed:21149639, ECO:0000269|PubMed:21242460, ECO:0000269|PubMed:21427217, ECO:0000269|PubMed:23135268, ECO:0000269|PubMed:23283935, ECO:0000269|PubMed:23285008, ECO:0000269|PubMed:23674134}.	MISCELLANEOUS: Does not bind estradiol according to PubMed:18566127 and PubMed:16645038.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic chromosome condensation [GO:0030263]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucose stimulus [GO:0071333]; cellular response to mineralocorticoid stimulus [GO:0071389]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to tumor necrosis factor [GO:0071356]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; negative regulation of cell cycle process [GO:0010948]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte activation [GO:0002695]; negative regulation of lipid biosynthetic process [GO:0051055]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; nervous system development [GO:0007399]; neuronal action potential [GO:0019228]; nuclear fragmentation involved in apoptotic nuclear change [GO:0030264]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cardiac vascular smooth muscle cell differentiation [GO:2000724]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of gene expression [GO:0010628]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of insulin secretion [GO:0032024]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of uterine smooth muscle contraction [GO:0070474]; regulation of cell cycle [GO:0051726]; regulation of cytosolic calcium ion concentration [GO:0051480]; steroid hormone mediated signaling pathway [GO:0043401]; vasodilation [GO:0042311]	axon [GO:0030424]; axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine head [GO:0044327]; dendritic spine membrane [GO:0032591]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; intracellular membrane-bounded organelle [GO:0043231]; keratin filament [GO:0045095]; mitochondrial membrane [GO:0031966]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]	chromatin binding [GO:0003682]; G protein-coupled estrogen receptor activity [GO:0038054]; G protein-coupled receptor activity [GO:0004930]; nuclear estrogen receptor activity [GO:0030284]; steroid binding [GO:0005496]; steroid hormone binding [GO:1990239]	axon [GO:0030424]; axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine head [GO:0044327]; dendritic spine membrane [GO:0032591]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; intracellular membrane-bounded organelle [GO:0043231]; keratin filament [GO:0045095]; mitochondrial membrane [GO:0031966]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; chromatin binding [GO:0003682]; G protein-coupled estrogen receptor activity [GO:0038054]; G protein-coupled receptor activity [GO:0004930]; nuclear estrogen receptor activity [GO:0030284]; steroid binding [GO:0005496]; steroid hormone binding [GO:1990239]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic chromosome condensation [GO:0030263]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucose stimulus [GO:0071333]; cellular response to mineralocorticoid stimulus [GO:0071389]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to tumor necrosis factor [GO:0071356]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; negative regulation of cell cycle process [GO:0010948]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte activation [GO:0002695]; negative regulation of lipid biosynthetic process [GO:0051055]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; nervous system development [GO:0007399]; neuronal action potential [GO:0019228]; nuclear fragmentation involved in apoptotic nuclear change [GO:0030264]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cardiac vascular smooth muscle cell differentiation [GO:2000724]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of gene expression [GO:0010628]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of insulin secretion [GO:0032024]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of uterine smooth muscle contraction [GO:0070474]; regulation of cell cycle [GO:0051726]; regulation of cytosolic calcium ion concentration [GO:0051480]; steroid hormone mediated signaling pathway [GO:0043401]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18566127}; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Postsynaptic density {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalized with BSN to the active zone of presynaptic density. Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes (By similarity). Endocytosed in a agonist- and arrestin-independent manner. Colocalized with RAMP3 and clathrin-coated pits at the plasma membrane. Colocalized with transferrin receptor at the plasma membrane and perinuclear region. Accumulated and colocalized with RAB11 proteins in recycling endosomes and trans-Golgi network (TGN), but does neither recycle back to the cell surface nor traffics to late endosome or lysosome. Colocalized with calnexin in the endoplasmic reticulum. Traffics to intracellular sites via cytokeratin intermediate filaments like KRT7 and KRT8 after constitutive endocytosis in epithelial cells. Colocalized with EGFR in the nucleus of agonist-induced cancer-associated fibroblasts (CAF). {ECO:0000250}.
Q99536	reviewed	VAT1_HUMAN	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-)	VAT1	Homo sapiens (Human)	393	FUNCTION: Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150, ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}.		negative regulation of mitochondrial fusion [GO:0010637]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]	oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270]; negative regulation of mitochondrial fusion [GO:0010637]	SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm and a small amount is associated with mitochondria. {ECO:0000250}.
Q99538	reviewed	LGMN_HUMAN	Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (AEP) (Protease, cysteine 1)	LGMN PRSC1	Homo sapiens (Human)	433	FUNCTION: Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:23776206). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:23776206). Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (PubMed:9872320). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules (By similarity). Required for normal degradation of internalized EGFR (By similarity). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). {ECO:0000250|UniProtKB:O89017, ECO:0000269|PubMed:23776206, ECO:0000269|PubMed:9872320}.		activation of cysteine-type endopeptidase activity [GO:0097202]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; associative learning [GO:0008306]; cellular response to amyloid-beta [GO:1904646]; cellular response to calcium ion [GO:0071277]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; dendritic spine organization [GO:0097061]; memory [GO:0007613]; negative regulation of ERBB signaling pathway [GO:1901185]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of monocyte chemotaxis [GO:0090026]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; receptor catabolic process [GO:0032801]; renal system process [GO:0003014]; response to acidic pH [GO:0010447]; self proteolysis [GO:0097264]; vacuolar protein processing [GO:0006624]; vitamin D metabolic process [GO:0042359]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; endolysosome lumen [GO:0036021]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]	cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233]; tau protein binding [GO:0048156]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; endolysosome lumen [GO:0036021]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233]; tau protein binding [GO:0048156]; activation of cysteine-type endopeptidase activity [GO:0097202]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; associative learning [GO:0008306]; cellular response to amyloid-beta [GO:1904646]; cellular response to calcium ion [GO:0071277]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; dendritic spine organization [GO:0097061]; memory [GO:0007613]; negative regulation of ERBB signaling pathway [GO:1901185]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of monocyte chemotaxis [GO:0090026]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; receptor catabolic process [GO:0032801]; renal system process [GO:0003014]; response to acidic pH [GO:0010447]; self proteolysis [GO:0097264]; vacuolar protein processing [GO:0006624]; vitamin D metabolic process [GO:0042359]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:9872320}.
Q99541	reviewed	PLIN2_HUMAN	Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP)	PLIN2 ADFP	Homo sapiens (Human)	437	FUNCTION: Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. {ECO:0000269|PubMed:34077757}.		cellular response to glucose starvation [GO:0042149]; lipid droplet disassembly [GO:1905691]; lipid storage [GO:0019915]; long-chain fatty acid transport [GO:0015909]; positive regulation of sequestering of triglyceride [GO:0010890]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cellular response to glucose starvation [GO:0042149]; lipid droplet disassembly [GO:1905691]; lipid storage [GO:0019915]; long-chain fatty acid transport [GO:0015909]; positive regulation of sequestering of triglyceride [GO:0010890]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P43883}; Peripheral membrane protein {ECO:0000250|UniProtKB:P43883}. Lipid droplet {ECO:0000269|PubMed:34077757, ECO:0000305|PubMed:26357594}.
Q99542	reviewed	MMP19_HUMAN	Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) (Matrix metalloproteinase-18) (MMP-18)	MMP19 MMP18 RASI	Homo sapiens (Human)	508	FUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. {ECO:0000269|PubMed:10809722, ECO:0000269|PubMed:10922468}.	MISCELLANEOUS: Autoantigen anti-MMP19 are frequent in RA patients. {ECO:0000269|PubMed:9562866}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q99543	reviewed	DNJC2_HUMAN	DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed]	DNAJC2 MPHOSPH11 MPP11 ZRF1	Homo sapiens (Human)	621	FUNCTION: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. {ECO:0000269|PubMed:15802566, ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}.	MISCELLANEOUS: Constitutes a myeloid leukemia-associated antigen and might be a target for leukemia T-cell therapy.	'de novo' cotranslational protein folding [GO:0051083]; chromatin organization [GO:0006325]; DNA replication [GO:0006260]; negative regulation of DNA biosynthetic process [GO:2000279]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cellular response to heat [GO:1900034]; regulation of translational fidelity [GO:0006450]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATPase activator activity [GO:0001671]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; Hsp70 protein binding [GO:0030544]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; ubiquitin modification-dependent histone binding [GO:0061649]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATPase activator activity [GO:0001671]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; Hsp70 protein binding [GO:0030544]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; ubiquitin modification-dependent histone binding [GO:0061649]; 'de novo' cotranslational protein folding [GO:0051083]; chromatin organization [GO:0006325]; DNA replication [GO:0006260]; negative regulation of DNA biosynthetic process [GO:2000279]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cellular response to heat [GO:1900034]; regulation of translational fidelity [GO:0006450]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21179169}. Cytoplasm, cytosol {ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}.
Q99547	reviewed	MPH6_HUMAN	M-phase phosphoprotein 6	MPHOSPH6 MPP6	Homo sapiens (Human)	160	FUNCTION: RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. {ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:26166824}.		maturation of 5.8S rRNA [GO:0000460]	cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; maturation of 5.8S rRNA [GO:0000460]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm. Note=Cytoplasmic in M phase.
Q99549	reviewed	MPP8_HUMAN	M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3)	MPHOSPH8 MPP8	Homo sapiens (Human)	860	FUNCTION: Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; regulation of DNA methylation [GO:0044030]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; regulation of DNA methylation [GO:0044030]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:23416073, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:8885239}. Chromosome {ECO:0000269|PubMed:23416073, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500}. Note=Detected on heterochromatin (PubMed:20871592, PubMed:26022416). Dissociates from chromatin during interphase and early mitosis (PubMed:23416073). Detected on nucleosomes (PubMed:20871592). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:23416073, ECO:0000269|PubMed:26022416}.
Q99550	reviewed	MPP9_HUMAN	M-phase phosphoprotein 9	MPHOSPH9 MPP9	Homo sapiens (Human)	1183	FUNCTION: Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). {ECO:0000269|PubMed:30375385}.		negative regulation of cilium assembly [GO:1902018]	centriole [GO:0005814]; centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]		centriole [GO:0005814]; centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; negative regulation of cilium assembly [GO:1902018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:30375385}. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30375385}. Note=Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole (PubMed:21399614). Recruited by KIF24 to the distal end of mother centriole where it forms a ring-like structure (PubMed:30375385). {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:30375385}.
Q99551	reviewed	MTEF1_HUMAN	Transcription termination factor 1, mitochondrial (Mitochondrial transcription termination factor 1) (mTERF) (mTERF1)	MTERF1 MTERF	Homo sapiens (Human)	399	FUNCTION: Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. {ECO:0000269|PubMed:20550934}.		DNA geometric change [GO:0032392]; DNA-templated transcription termination [GO:0006353]; regulation of DNA-templated transcription [GO:0006355]; termination of mitochondrial transcription [GO:0006393]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	double-stranded DNA binding [GO:0003690]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; double-stranded DNA binding [GO:0003690]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; DNA geometric change [GO:0032392]; DNA-templated transcription termination [GO:0006353]; regulation of DNA-templated transcription [GO:0006355]; termination of mitochondrial transcription [GO:0006393]	SUBCELLULAR LOCATION: Mitochondrion.
Q99558	reviewed	M3K14_HUMAN	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)	MAP3K14 NIK	Homo sapiens (Human)	947	FUNCTION: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner. {ECO:0000269|PubMed:15084608}.		canonical NF-kappaB signal transduction [GO:0007249]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; immune response [GO:0006955]; non-canonical NF-kappaB signal transduction [GO:0038061]; phosphorylation [GO:0016310]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; NF-kappaB-inducing kinase activity [GO:0004704]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; NF-kappaB-inducing kinase activity [GO:0004704]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; immune response [GO:0006955]; non-canonical NF-kappaB signal transduction [GO:0038061]; phosphorylation [GO:0016310]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Cytoplasm.
Q99567	reviewed	NUP88_HUMAN	Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88)	NUP88	Homo sapiens (Human)	741	FUNCTION: Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}.		mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; structural constituent of nuclear pore [GO:0017056]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:30543681}.
Q99569	reviewed	PKP4_HUMAN	Plakophilin-4 (p0071)	PKP4	Homo sapiens (Human)	1192	FUNCTION: Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}.		cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-cell signaling [GO:0007267]; positive regulation of cytokinesis [GO:0032467]; positive regulation of GTPase activity [GO:0043547]; regulation of cell adhesion [GO:0030155]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; desmosome [GO:0030057]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]	cadherin binding [GO:0045296]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; desmosome [GO:0030057]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]; cadherin binding [GO:0045296]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-cell signaling [GO:0007267]; positive regulation of cytokinesis [GO:0032467]; positive regulation of GTPase activity [GO:0043547]; regulation of cell adhesion [GO:0030155]	SUBCELLULAR LOCATION: Cell junction, desmosome {ECO:0000269|PubMed:17115030}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17115030}. Midbody {ECO:0000269|PubMed:17115030}. Cell membrane {ECO:0000269|PubMed:17115030}; Peripheral membrane protein {ECO:0000269|PubMed:17115030}. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.
Q99570	reviewed	PI3R4_HUMAN	Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)	PIK3R4 VPS15	Homo sapiens (Human)	1358	FUNCTION: Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}.		autophagosome maturation [GO:0097352]; autophagy of peroxisome [GO:0030242]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; protein phosphorylation [GO:0006468]; protein targeting to lysosome [GO:0006622]; protein targeting to vacuole [GO:0006623]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]	autophagosome [GO:0005776]; axoneme [GO:0005930]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus-vacuole junction [GO:0071561]; phagocytic vesicle membrane [GO:0030670]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	autophagosome [GO:0005776]; axoneme [GO:0005930]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus-vacuole junction [GO:0071561]; phagocytic vesicle membrane [GO:0030670]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; autophagosome maturation [GO:0097352]; autophagy of peroxisome [GO:0030242]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; protein phosphorylation [GO:0006468]; protein targeting to lysosome [GO:0006622]; protein targeting to vacuole [GO:0006623]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]	SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:14617358}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q8VD65, ECO:0000305}.
Q99571	reviewed	P2RX4_HUMAN	P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor)	P2RX4	Homo sapiens (Human)	388	FUNCTION: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:9016352). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:35165166). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Participates also in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166). Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity). {ECO:0000250|UniProtKB:P51577, ECO:0000250|UniProtKB:Q9JJX6, ECO:0000269|PubMed:35165166, ECO:0000269|PubMed:9016352}.		apoptotic signaling pathway [GO:0097190]; behavioral response to pain [GO:0048266]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; cellular response to zinc ion [GO:0071294]; endothelial cell activation [GO:0042118]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; neuronal action potential [GO:0019228]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of prostaglandin secretion [GO:0032308]; purinergic nucleotide receptor signaling pathway [GO:0035590]; regulation of blood pressure [GO:0008217]; regulation of cardiac muscle contraction [GO:0055117]; regulation of chemotaxis [GO:0050920]; regulation of sodium ion transport [GO:0002028]; relaxation of cardiac muscle [GO:0055119]; response to ATP [GO:0033198]; response to axon injury [GO:0048678]; response to fluid shear stress [GO:0034405]; response to ischemia [GO:0002931]; sensory perception of pain [GO:0019233]; sensory perception of touch [GO:0050975]; signal transduction [GO:0007165]; tissue homeostasis [GO:0001894]	cell body [GO:0044297]; cell junction [GO:0030054]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; terminal bouton [GO:0043195]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; copper ion binding [GO:0005507]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]; purinergic nucleotide receptor activity [GO:0001614]; signaling receptor binding [GO:0005102]; zinc ion binding [GO:0008270]	cell body [GO:0044297]; cell junction [GO:0030054]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; terminal bouton [GO:0043195]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; copper ion binding [GO:0005507]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]; purinergic nucleotide receptor activity [GO:0001614]; signaling receptor binding [GO:0005102]; zinc ion binding [GO:0008270]; apoptotic signaling pathway [GO:0097190]; behavioral response to pain [GO:0048266]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; cellular response to zinc ion [GO:0071294]; endothelial cell activation [GO:0042118]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; neuronal action potential [GO:0019228]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of prostaglandin secretion [GO:0032308]; purinergic nucleotide receptor signaling pathway [GO:0035590]; regulation of blood pressure [GO:0008217]; regulation of cardiac muscle contraction [GO:0055117]; regulation of chemotaxis [GO:0050920]; regulation of sodium ion transport [GO:0002028]; relaxation of cardiac muscle [GO:0055119]; response to ATP [GO:0033198]; response to axon injury [GO:0048678]; response to fluid shear stress [GO:0034405]; response to ischemia [GO:0002931]; sensory perception of pain [GO:0019233]; sensory perception of touch [GO:0050975]; signal transduction [GO:0007165]; tissue homeostasis [GO:0001894]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10515189, ECO:0000269|PubMed:23303206, ECO:0000269|PubMed:28326637}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:24817123}; Multi-pass membrane protein {ECO:0000255}.
Q99572	reviewed	P2RX7_HUMAN	P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor)	P2RX7	Homo sapiens (Human)	595	FUNCTION: Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206). {ECO:0000269|PubMed:21821797, ECO:0000269|PubMed:23303206, ECO:0000269|PubMed:28326637}.	MISCELLANEOUS: [Isoform B]: Predominant form in many tissues. {ECO:0000305}.; MISCELLANEOUS: [Isoform H]: Non-functional channel. {ECO:0000305}.	apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling using extracellular calcium source [GO:0035585]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway involved in cell-cell signaling [GO:1905114]; cellular response to ATP [GO:0071318]; cellular response to dsRNA [GO:0071359]; cellular response to extracellular stimulus [GO:0031668]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; gamma-aminobutyric acid secretion [GO:0014051]; glutamate secretion [GO:0014047]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrial depolarization [GO:0051882]; mitochondrion organization [GO:0007005]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid transfer to membrane [GO:0006649]; plasma membrane phospholipid scrambling [GO:0017121]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell apoptotic process [GO:0070234]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; prostaglandin secretion [GO:0032310]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; protein secretion [GO:0009306]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of killing of cells of another organism [GO:0051709]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell apoptotic process [GO:0070231]; T cell homeostasis [GO:0043029]; T cell mediated cytotoxicity [GO:0001913]; T cell proliferation [GO:0042098]; vesicle budding from membrane [GO:0006900]	bleb [GO:0032059]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]	ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; purinergic nucleotide receptor activity [GO:0001614]; signaling receptor binding [GO:0005102]	bleb [GO:0032059]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; purinergic nucleotide receptor activity [GO:0001614]; signaling receptor binding [GO:0005102]; apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling using extracellular calcium source [GO:0035585]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway involved in cell-cell signaling [GO:1905114]; cellular response to ATP [GO:0071318]; cellular response to dsRNA [GO:0071359]; cellular response to extracellular stimulus [GO:0031668]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; gamma-aminobutyric acid secretion [GO:0014051]; glutamate secretion [GO:0014047]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrial depolarization [GO:0051882]; mitochondrion organization [GO:0007005]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid transfer to membrane [GO:0006649]; plasma membrane phospholipid scrambling [GO:0017121]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell apoptotic process [GO:0070234]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; prostaglandin secretion [GO:0032310]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; protein secretion [GO:0009306]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of killing of cells of another organism [GO:0051709]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell apoptotic process [GO:0070231]; T cell homeostasis [GO:0043029]; T cell mediated cytotoxicity [GO:0001913]; T cell proliferation [GO:0042098]; vesicle budding from membrane [GO:0006900]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12107182, ECO:0000269|PubMed:23303206, ECO:0000269|PubMed:28326637}; Multi-pass membrane protein {ECO:0000255}.
Q99574	reviewed	NEUS_HUMAN	Neuroserpin (Peptidase inhibitor 12) (PI-12) (Serpin I1)	SERPINI1 PI12	Homo sapiens (Human)	410	FUNCTION: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable). {ECO:0000269|PubMed:11880376, ECO:0000269|PubMed:19265707, ECO:0000269|PubMed:19285087, ECO:0000269|PubMed:26329378, ECO:0000269|PubMed:9442076, ECO:0000305}.		central nervous system development [GO:0007417]; peripheral nervous system development [GO:0007422]; positive regulation of neuron projection development [GO:0010976]	cytoplasmic vesicle lumen [GO:0060205]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; secretory granule lumen [GO:0034774]	serine-type endopeptidase inhibitor activity [GO:0004867]	cytoplasmic vesicle lumen [GO:0060205]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; secretory granule lumen [GO:0034774]; serine-type endopeptidase inhibitor activity [GO:0004867]; central nervous system development [GO:0007417]; peripheral nervous system development [GO:0007422]; positive regulation of neuron projection development [GO:0010976]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17040209, ECO:0000269|PubMed:25326458}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000305|PubMed:17040209}. Perikaryon {ECO:0000269|PubMed:17040209}.
Q99575	reviewed	POP1_HUMAN	Ribonucleases P/MRP protein subunit POP1 (hPOP1)	POP1 KIAA0061	Homo sapiens (Human)	1024	FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:8918471, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}.		tRNA 5'-leader removal [GO:0001682]; tRNA catabolic process [GO:0016078]; tRNA processing [GO:0008033]	extracellular space [GO:0005615]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]	ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723]	extracellular space [GO:0005615]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]; ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723]; tRNA 5'-leader removal [GO:0001682]; tRNA catabolic process [GO:0016078]; tRNA processing [GO:0008033]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:8918471}.
Q99576	reviewed	T22D3_HUMAN	TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R)	TSC22D3 DSIPI GILZ	Homo sapiens (Human)	134	FUNCTION: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed:12393603). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (PubMed:11468175). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity). {ECO:0000250|UniProtKB:Q9Z2S7, ECO:0000269|PubMed:11468175, ECO:0000269|PubMed:12393603, ECO:0000269|PubMed:15031210}.; FUNCTION: [Isoform 1]: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. {ECO:0000250|UniProtKB:Q9Z2S7}.		negative regulation of activation-induced cell death of T cells [GO:0070236]; regulation of transcription by RNA polymerase II [GO:0006357]; response to osmotic stress [GO:0006970]	cytosol [GO:0005829]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleus [GO:0005634]; negative regulation of activation-induced cell death of T cells [GO:0070236]; regulation of transcription by RNA polymerase II [GO:0006357]; response to osmotic stress [GO:0006970]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q9Z2S7}. Nucleus {ECO:0000250|UniProtKB:Q9Z2S7}. Note=Localization depends on differentiation status of myoblasts (By similarity). In undifferentiated myoblasts; localizes to the cytoplasm, but in differentiating myoblast; localizes to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9Z2S7}.
Q99578	reviewed	RIT2_HUMAN	GTP-binding protein Rit2 (EC 3.6.5.2) (Ras-like protein expressed in neurons) (Ras-like without CAAX protein 2)	RIT2 RIN ROC2	Homo sapiens (Human)	217	FUNCTION: Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator. {ECO:0000250|UniProtKB:P70425}.	MISCELLANEOUS: Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members. {ECO:0000250}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; chemical synaptic transmission [GO:0007268]; intracellular signal transduction [GO:0035556]; maintenance of protein location in cell [GO:0032507]; negative regulation of neuron projection development [GO:0010977]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Ras protein signal transduction [GO:0007265]; regulation of calcium-mediated signaling [GO:0050848]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of endocytosis [GO:0030100]; regulation of protein phosphorylation [GO:0001932]; small GTPase mediated signal transduction [GO:0007264]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic tree [GO:0097447]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]	calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; semaphorin receptor binding [GO:0030215]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic tree [GO:0097447]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; semaphorin receptor binding [GO:0030215]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; chemical synaptic transmission [GO:0007268]; intracellular signal transduction [GO:0035556]; maintenance of protein location in cell [GO:0032507]; negative regulation of neuron projection development [GO:0010977]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Ras protein signal transduction [GO:0007265]; regulation of calcium-mediated signaling [GO:0050848]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of endocytosis [GO:0030100]; regulation of protein phosphorylation [GO:0001932]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12934100, ECO:0000269|PubMed:16122393}. Cell membrane {ECO:0000269|PubMed:16122393}. Note=Colocalizes with PLXNB3 at the plasma membrane (PubMed:16122393). {ECO:0000269|PubMed:16122393}.
Q99581	reviewed	FEV_HUMAN	Protein FEV (Fifth Ewing variant protein) (PC12 ETS domain-containing transcription factor 1) (PC12 ETS factor 1) (Pet-1)	FEV PET1	Homo sapiens (Human)	238	FUNCTION: Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. {ECO:0000269|PubMed:12761502}.		neuron fate specification [GO:0048665]; neuron maturation [GO:0042551]; positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; neuron fate specification [GO:0048665]; neuron maturation [GO:0042551]; positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:12761502}.
Q99583	reviewed	MNT_HUMAN	Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX)	MNT BHLHD3 ROX	Homo sapiens (Human)	582	FUNCTION: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.		cellular senescence [GO:0090398]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cellular senescence [GO:0090398]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
Q99584	reviewed	S10AD_HUMAN	Protein S100-A13 (S100 calcium-binding protein A13)	S100A13	Homo sapiens (Human)	98	FUNCTION: Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). {ECO:0000250|UniProtKB:P97352, ECO:0000269|PubMed:12746488, ECO:0000269|PubMed:20863990}.		mast cell degranulation [GO:0043303]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-1 alpha production [GO:0032730]; protein transport [GO:0015031]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; copper ion binding [GO:0005507]; fibroblast growth factor binding [GO:0017134]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]; RAGE receptor binding [GO:0050786]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; copper ion binding [GO:0005507]; fibroblast growth factor binding [GO:0017134]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]; RAGE receptor binding [GO:0050786]; zinc ion binding [GO:0008270]; mast cell degranulation [GO:0043303]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-1 alpha production [GO:0032730]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm. Secreted. Note=Secretion is mediated by exposure to stress and requires copper ions.
Q99590	reviewed	SCAFB_HUMAN	Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129)	SCAF11 CASP11 SFRS2IP SIP1 SRSF2IP	Homo sapiens (Human)	1463	FUNCTION: Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]	nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9447963}.
Q99592	reviewed	ZBT18_HUMAN	Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger protein 238) (Zinc finger protein C2H2-171)	ZBTB18 RP58 TAZ1 ZNF238	Homo sapiens (Human)	522	FUNCTION: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. {ECO:0000269|PubMed:9756912}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue development [GO:0007519]	heterochromatin [GO:0000792]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	heterochromatin [GO:0000792]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Nucleus. Note=Associates with condensed chromatin.
Q99593	reviewed	TBX5_HUMAN	T-box transcription factor TBX5 (T-box protein 5)	TBX5	Homo sapiens (Human)	518	FUNCTION: DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:25725155, PubMed:25963046, PubMed:29174768, PubMed:26917986, PubMed:27035640, PubMed:8988164). Binds to the core DNA motif of NPPA promoter (PubMed:26926761). {ECO:0000269|PubMed:25725155, ECO:0000269|PubMed:25963046, ECO:0000269|PubMed:26917986, ECO:0000269|PubMed:26926761, ECO:0000269|PubMed:27035640, ECO:0000269|PubMed:29174768, ECO:0000269|PubMed:8988164}.		atrial septum morphogenesis [GO:0060413]; atrioventricular bundle cell differentiation [GO:0003167]; atrioventricular node cell development [GO:0060928]; atrioventricular node cell fate commitment [GO:0060929]; atrioventricular valve morphogenesis [GO:0003181]; bundle of His cell to Purkinje myocyte communication by electrical coupling [GO:0086054]; bundle of His development [GO:0003166]; cardiac left ventricle formation [GO:0003218]; cardiac muscle cell proliferation [GO:0060038]; cell fate specification [GO:0001708]; cell migration involved in coronary vasculogenesis [GO:0060980]; cell-cell signaling [GO:0007267]; cell-cell signaling involved in cardiac conduction [GO:0086019]; embryonic forelimb morphogenesis [GO:0035115]; embryonic limb morphogenesis [GO:0030326]; endocardial cushion development [GO:0003197]; forelimb morphogenesis [GO:0035136]; heart development [GO:0007507]; lung development [GO:0030324]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; pattern specification process [GO:0007389]; pericardium development [GO:0060039]; positive regulation of cardiac conduction [GO:1903781]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901846]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of transcription by RNA polymerase II [GO:0006357]; sinoatrial node development [GO:0003163]; transcription by RNA polymerase II [GO:0006366]; ventricular septum development [GO:0003281]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; atrial septum morphogenesis [GO:0060413]; atrioventricular bundle cell differentiation [GO:0003167]; atrioventricular node cell development [GO:0060928]; atrioventricular node cell fate commitment [GO:0060929]; atrioventricular valve morphogenesis [GO:0003181]; bundle of His cell to Purkinje myocyte communication by electrical coupling [GO:0086054]; bundle of His development [GO:0003166]; cardiac left ventricle formation [GO:0003218]; cardiac muscle cell proliferation [GO:0060038]; cell fate specification [GO:0001708]; cell migration involved in coronary vasculogenesis [GO:0060980]; cell-cell signaling [GO:0007267]; cell-cell signaling involved in cardiac conduction [GO:0086019]; embryonic forelimb morphogenesis [GO:0035115]; embryonic limb morphogenesis [GO:0030326]; endocardial cushion development [GO:0003197]; forelimb morphogenesis [GO:0035136]; heart development [GO:0007507]; lung development [GO:0030324]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; pattern specification process [GO:0007389]; pericardium development [GO:0060039]; positive regulation of cardiac conduction [GO:1903781]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901846]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of transcription by RNA polymerase II [GO:0006357]; sinoatrial node development [GO:0003163]; transcription by RNA polymerase II [GO:0006366]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201, ECO:0000269|PubMed:29174768}. Cytoplasm {ECO:0000269|PubMed:29174768}. Note=Shuttles between the cytoplasm and the nucleus. Acetylation at Lys-339 promotes nuclear retention. {ECO:0000269|PubMed:29174768}.
Q99594	reviewed	TEAD3_HUMAN	Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3)	TEAD3 TEAD5 TEF5	Homo sapiens (Human)	435	FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.		asymmetric neuroblast division [GO:0055059]; embryonic organ development [GO:0048568]; female pregnancy [GO:0007565]; hippo signaling [GO:0035329]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; asymmetric neuroblast division [GO:0055059]; embryonic organ development [GO:0048568]; female pregnancy [GO:0007565]; hippo signaling [GO:0035329]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q99595	reviewed	TI17A_HUMAN	Mitochondrial import inner membrane translocase subunit Tim17-A (Inner membrane preprotein translocase Tim17a)	TIMM17A MIMT17 TIM17 TIM17A TIMM17	Homo sapiens (Human)	171	FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.		intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	protein transmembrane transporter activity [GO:0008320]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; protein transmembrane transporter activity [GO:0008320]; intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
Q99598	reviewed	TSNAX_HUMAN	Translin-associated protein X (Translin-associated factor X)	TSNAX TRAX	Homo sapiens (Human)	290	FUNCTION: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. {ECO:0000269|PubMed:12036294, ECO:0000269|PubMed:21552258}.		cell differentiation [GO:0030154]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; siRNA processing [GO:0030422]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoribonuclease complex [GO:1902555]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	A2A adenosine receptor binding [GO:0031687]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoribonuclease complex [GO:1902555]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; A2A adenosine receptor binding [GO:0031687]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697]; cell differentiation [GO:0030154]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; siRNA processing [GO:0030422]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Golgi apparatus {ECO:0000250}. Nucleus. Note=Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN. {ECO:0000250}.
Q99607	reviewed	ELF4_HUMAN	ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor)	ELF4 ELFR MEF	Homo sapiens (Human)	663	FUNCTION: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Transactivates the PRF1 promoter in natural killer (NK) cells and CD8+ T cells (PubMed:34326534). Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN (PubMed:34326534, PubMed:35266071). Is a negative regulator of pro-inflammatory cytokines expression including IL17A, IL1B, IL6, TNFA and CXCL1 (PubMed:34326534, PubMed:35266071). Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses (By similarity) (PubMed:34326534, PubMed:35266071). {ECO:0000250, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:14625302, ECO:0000269|PubMed:14976184, ECO:0000269|PubMed:19380490, ECO:0000269|PubMed:34326534, ECO:0000269|PubMed:35266071, ECO:0000269|PubMed:8895518, ECO:0000269|PubMed:9524226}.		natural killer cell proliferation [GO:0001787]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; NK T cell proliferation [GO:0001866]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; natural killer cell proliferation [GO:0001787]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; NK T cell proliferation [GO:0001866]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000269|PubMed:14976184}. Note=Accumulation into PML nuclear bodies is mediated by PML.
Q99608	reviewed	NECD_HUMAN	Necdin	NDN	Homo sapiens (Human)	321	FUNCTION: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences (By similarity). {ECO:0000250}.	MISCELLANEOUS: Located in the Prader-Willi syndrome (PWS) chromosome region. Prader-Willi syndrome is a contiguous gene syndrome resulting from deletion of the paternal copies of the imprinted SNRPN gene, the necdin gene, and possibly other genes within the chromosome region 15q11-q13.	axon extension [GO:0048675]; axonal fasciculation [GO:0007413]; central nervous system development [GO:0007417]; genomic imprinting [GO:0071514]; glial cell migration [GO:0008347]; multicellular organismal-level homeostasis [GO:0048871]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of protein deacetylation [GO:0090312]; post-embryonic development [GO:0009791]; respiratory system process [GO:0003016]; sensory perception of pain [GO:0019233]	cell projection [GO:0042995]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; gamma-tubulin binding [GO:0043015]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cell projection [GO:0042995]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; gamma-tubulin binding [GO:0043015]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; axon extension [GO:0048675]; axonal fasciculation [GO:0007413]; central nervous system development [GO:0007417]; genomic imprinting [GO:0071514]; glial cell migration [GO:0008347]; multicellular organismal-level homeostasis [GO:0048871]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of protein deacetylation [GO:0090312]; post-embryonic development [GO:0009791]; respiratory system process [GO:0003016]; sensory perception of pain [GO:0019233]	SUBCELLULAR LOCATION: Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.
Q99611	reviewed	SPS2_HUMAN	Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2)	SEPHS2 SPS2	Homo sapiens (Human)	448	FUNCTION: Synthesizes selenophosphate from selenide and ATP. {ECO:0000250|UniProtKB:P49903}.		phosphorylation [GO:0016310]; selenium compound metabolic process [GO:0001887]; selenocysteine biosynthetic process [GO:0016260]; selenocysteine metabolic process [GO:0016259]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; selenide, water dikinase activity [GO:0004756]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; selenide, water dikinase activity [GO:0004756]; phosphorylation [GO:0016310]; selenium compound metabolic process [GO:0001887]; selenocysteine biosynthetic process [GO:0016260]; selenocysteine metabolic process [GO:0016259]	
Q99612	reviewed	KLF6_HUMAN	Krueppel-like factor 6 (B-cell-derived protein 1) (Core promoter element-binding protein) (GC-rich sites-binding factor GBF) (Proto-oncogene BCD1) (Suppressor of tumorigenicity 12 protein) (Transcription factor Zf9)	KLF6 BCD1 COPEB CPBP ST12	Homo sapiens (Human)	283	FUNCTION: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development. {ECO:0000250}.		B cell differentiation [GO:0030183]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; B cell differentiation [GO:0030183]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q99613	reviewed	EIF3C_HUMAN	Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)	EIF3C EIF3S8	Homo sapiens (Human)	913	FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.		formation of cytoplasmic translation initiation complex [GO:0001732]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; translational initiation [GO:0006413]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]; formation of cytoplasmic translation initiation complex [GO:0001732]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
Q99615	reviewed	DNJC7_HUMAN	DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2)	DNAJC7 TPR2 TTC2	Homo sapiens (Human)	494	FUNCTION: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:12853476, ECO:0000269|PubMed:18620420}.		chaperone cofactor-dependent protein refolding [GO:0051085]; protein folding [GO:0006457]; regulation of cellular response to heat [GO:1900034]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	ATPase activator activity [GO:0001671]; heat shock protein binding [GO:0031072]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ATPase activator activity [GO:0001671]; heat shock protein binding [GO:0031072]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein folding [GO:0006457]; regulation of cellular response to heat [GO:1900034]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11573955, ECO:0000269|PubMed:12853476}. Nucleus {ECO:0000269|PubMed:11573955}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QYI3}. Note=Colocalizes with NR1I3 to microtubules. {ECO:0000250|UniProtKB:Q9QYI3}.
Q99616	reviewed	CCL13_HUMAN	C-C motif chemokine 13 (CK-beta-10) (Monocyte chemoattractant protein 4) (Monocyte chemotactic protein 4) (MCP-4) (NCC-1) (Small-inducible cytokine A13) [Cleaved into: C-C motif chemokine 13, long chain; C-C motif chemokine 13, medium chain; C-C motif chemokine 13, short chain]	CCL13 MCP4 NCC1 SCYA13	Homo sapiens (Human)	98	FUNCTION: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.	MISCELLANEOUS: This protein can bind heparin.	antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; killing of cells of another organism [GO:0031640]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of cell shape [GO:0008360]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; signaling receptor binding [GO:0005102]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; killing of cells of another organism [GO:0031640]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of cell shape [GO:0008360]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
Q99619	reviewed	SPSB2_HUMAN	SPRY domain-containing SOCS box protein 2 (SSB-2) (Gene-rich cluster protein C9)	SPSB2 GRCC9 SSB2	Homo sapiens (Human)	263	FUNCTION: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:21199876}.		intracellular signal transduction [GO:0035556]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; intracellular signal transduction [GO:0035556]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:21199876}. Note=Exhibits a diffuse cytosolic localization. {ECO:0000269|PubMed:21199876}.
Q99622	reviewed	C10_HUMAN	Protein C10	C12orf57 C10	Homo sapiens (Human)	126	FUNCTION: In brain, may be required for corpus callosum development. {ECO:0000269|PubMed:23453666}.		camera-type eye morphogenesis [GO:0048593]; cognition [GO:0050890]; corpus callosum morphogenesis [GO:0021540]; post-embryonic development [GO:0009791]; psychomotor behavior [GO:0036343]; regulation of skeletal muscle contraction [GO:0014819]; third ventricle development [GO:0021678]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]		cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; camera-type eye morphogenesis [GO:0048593]; cognition [GO:0050890]; corpus callosum morphogenesis [GO:0021540]; post-embryonic development [GO:0009791]; psychomotor behavior [GO:0036343]; regulation of skeletal muscle contraction [GO:0014819]; third ventricle development [GO:0021678]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23453666}.
Q99623	reviewed	PHB2_HUMAN	Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)	PHB2 BAP REA	Homo sapiens (Human)	299	FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:20959514, PubMed:11302691). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:20959514, PubMed:11302691). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}.		activation of phospholipase C activity [GO:0007202]; activation of protein kinase C activity [GO:1990051]; antiviral innate immune response [GO:0140374]; B cell activation [GO:0042113]; CD40 signaling pathway [GO:0023035]; cell migration [GO:0016477]; cellular response to hypoxia [GO:0071456]; cellular response to retinoic acid [GO:0071300]; intracellular estrogen receptor signaling pathway [GO:0030520]; mammary gland alveolus development [GO:0060749]; mammary gland branching involved in thelarche [GO:0060744]; mammary gland epithelial cell proliferation [GO:0033598]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of cardiolipin metabolic process [GO:1900208]; regulation of cytochrome-c oxidase activity [GO:1904959]; RIG-I signaling pathway [GO:0039529]; sister chromatid cohesion [GO:0007062]	axon [GO:0030424]; cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial prohibitin complex [GO:0035632]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991]	amide binding [GO:0033218]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; sphingolipid binding [GO:0046625]	axon [GO:0030424]; cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial prohibitin complex [GO:0035632]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991]; amide binding [GO:0033218]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; sphingolipid binding [GO:0046625]; activation of phospholipase C activity [GO:0007202]; activation of protein kinase C activity [GO:1990051]; antiviral innate immune response [GO:0140374]; B cell activation [GO:0042113]; CD40 signaling pathway [GO:0023035]; cell migration [GO:0016477]; cellular response to hypoxia [GO:0071456]; cellular response to retinoic acid [GO:0071300]; intracellular estrogen receptor signaling pathway [GO:0030520]; mammary gland alveolus development [GO:0060749]; mammary gland branching involved in thelarche [GO:0060744]; mammary gland epithelial cell proliferation [GO:0033598]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of cardiolipin metabolic process [GO:1900208]; regulation of cytochrome-c oxidase activity [GO:1904959]; RIG-I signaling pathway [GO:0039529]; sister chromatid cohesion [GO:0007062]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329}. Cytoplasm {ECO:0000269|PubMed:19496786, ECO:0000269|PubMed:32276428}. Nucleus {ECO:0000269|PubMed:19496786, ECO:0000269|PubMed:20959514}. Cell membrane {ECO:0000269|PubMed:22997079, ECO:0000269|PubMed:24003225}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane {ECO:0000305|PubMed:31522117}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion inner membrane {ECO:0000305|PubMed:31522117}.
Q99624	reviewed	S38A3_HUMAN	Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1)	SLC38A3 G17 NAT1 SN1 SNAT3	Homo sapiens (Human)	504	FUNCTION: Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity). The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:10823827). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10823827). Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity). {ECO:0000250|UniProtKB:Q9DCP2, ECO:0000250|UniProtKB:Q9JHZ9, ECO:0000269|PubMed:10823827}.		amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; asparagine transport [GO:0006867]; cellular response to potassium ion starvation [GO:0051365]; female pregnancy [GO:0007565]; glutamine secretion [GO:0010585]; glutamine transport [GO:0006868]; histidine transport [GO:0015817]; intracellular amino acid homeostasis [GO:0080144]; L-alanine transport [GO:0015808]; L-asparagine import across plasma membrane [GO:1903811]; L-glutamine import across plasma membrane [GO:1903803]; L-histidine import across plasma membrane [GO:1903810]; L-histidine transport [GO:1902024]; positive regulation of glutamine transport [GO:2000487]; positive regulation of transcription from RNA polymerase II promoter in response to acidic pH [GO:0061402]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; L-alanine transmembrane transporter activity [GO:0015180]; L-asparagine transmembrane transporter activity [GO:0015182]; L-asparagine, sodium:proton antiporter activity [GO:0140831]; L-glutamine transmembrane transporter activity [GO:0015186]; L-glutamine, sodium:proton antiporter activity [GO:0140830]; L-histidine transmembrane transporter activity [GO:0005290]; L-histidine, sodium:proton antiporter activity [GO:0140832]; neutral L-amino acid:sodium symporter activity [GO:0005295]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; L-alanine transmembrane transporter activity [GO:0015180]; L-asparagine transmembrane transporter activity [GO:0015182]; L-asparagine, sodium:proton antiporter activity [GO:0140831]; L-glutamine transmembrane transporter activity [GO:0015186]; L-glutamine, sodium:proton antiporter activity [GO:0140830]; L-histidine transmembrane transporter activity [GO:0005290]; L-histidine, sodium:proton antiporter activity [GO:0140832]; neutral L-amino acid:sodium symporter activity [GO:0005295]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; asparagine transport [GO:0006867]; cellular response to potassium ion starvation [GO:0051365]; female pregnancy [GO:0007565]; glutamine secretion [GO:0010585]; glutamine transport [GO:0006868]; histidine transport [GO:0015817]; intracellular amino acid homeostasis [GO:0080144]; L-alanine transport [GO:0015808]; L-asparagine import across plasma membrane [GO:1903811]; L-glutamine import across plasma membrane [GO:1903803]; L-histidine import across plasma membrane [GO:1903810]; L-histidine transport [GO:1902024]; positive regulation of glutamine transport [GO:2000487]; positive regulation of transcription from RNA polymerase II promoter in response to acidic pH [GO:0061402]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9DCP2}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9DCP2}. Note=The localization appears to be basolateral in the plasma membrane of hepatocytes surrounding the central vein. Localized at the cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelial cells. In astrocytes, the localization at cell membrane is decreased by ammonia through the PKC signaling. Expressed in both luminal and abluminal plasma membranes of larger microvessels and blood brain barrier (BBB) capillaries (By similarity). Restricted to the basolateral membranes of S3 segment cells of the proximal tubules (By similarity). {ECO:0000250|UniProtKB:Q9DCP2, ECO:0000250|UniProtKB:Q9JHZ9}.
Q99626	reviewed	CDX2_HUMAN	Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2)	CDX2 CDX3	Homo sapiens (Human)	313	FUNCTION: Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250|UniProtKB:P43241, ECO:0000250|UniProtKB:Q04649, ECO:0000269|PubMed:28473536}.		animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; blood vessel development [GO:0001568]; cell differentiation [GO:0030154]; endosome to lysosome transport [GO:0008333]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intestinal epithelial cell differentiation [GO:0060575]; labyrinthine layer development [GO:0060711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of somitogenesis [GO:0014807]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; stem cell differentiation [GO:0048863]; trophectodermal cell differentiation [GO:0001829]	chromatin [GO:0000785]; condensed nuclear chromosome [GO:0000794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; condensed nuclear chromosome [GO:0000794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; blood vessel development [GO:0001568]; cell differentiation [GO:0030154]; endosome to lysosome transport [GO:0008333]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intestinal epithelial cell differentiation [GO:0060575]; labyrinthine layer development [GO:0060711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of somitogenesis [GO:0014807]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; stem cell differentiation [GO:0048863]; trophectodermal cell differentiation [GO:0001829]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P43241}.
Q99627	reviewed	CSN8_HUMAN	COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)	COPS8 CSN8	Homo sapiens (Human)	209	FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.		activation of NF-kappaB-inducing kinase activity [GO:0007250]; COP9 signalosome assembly [GO:0010387]; negative regulation of cell population proliferation [GO:0008285]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; protein phosphorylation [GO:0006468]; regulation of protein neddylation [GO:2000434]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]		COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; COP9 signalosome assembly [GO:0010387]; negative regulation of cell population proliferation [GO:0008285]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; protein phosphorylation [GO:0006468]; regulation of protein neddylation [GO:2000434]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Q99633	reviewed	PRP18_HUMAN	Pre-mRNA-splicing factor 18 (PRP18 homolog) (hPRP18)	PRPF18 HPRP18	Homo sapiens (Human)	342	FUNCTION: Participates in the second step of pre-mRNA splicing. {ECO:0000269|PubMed:9000057}.		generation of catalytic spliceosome for second transesterification step [GO:0000350]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type post-spliceosomal complex [GO:0071021]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]		nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type post-spliceosomal complex [GO:0071021]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; generation of catalytic spliceosome for second transesterification step [GO:0000350]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Note=Colocalizes with spliceosomal snRNPs. {ECO:0000250}.
Q99638	reviewed	RAD9A_HUMAN	Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A)	RAD9A	Homo sapiens (Human)	391	FUNCTION: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex. {ECO:0000269|PubMed:10713044, ECO:0000269|PubMed:21659603}.		cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]	checkpoint clamp complex [GO:0030896]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5' exonuclease activity [GO:0008408]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]	checkpoint clamp complex [GO:0030896]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5' exonuclease activity [GO:0008408]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12628935}.
Q99640	reviewed	PMYT1_HUMAN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase)	PKMYT1 MYT1	Homo sapiens (Human)	499	FUNCTION: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:9001210}.		G2/M transition of mitotic cell cycle [GO:0000086]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; negative regulation of G2/MI transition of meiotic cell cycle [GO:0110031]; phosphorylation [GO:0016310]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic nuclear division [GO:0007088]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; G2/M transition of mitotic cell cycle [GO:0000086]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; negative regulation of G2/MI transition of meiotic cell cycle [GO:0110031]; phosphorylation [GO:0016310]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic nuclear division [GO:0007088]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}. Golgi apparatus membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}.
Q99643	reviewed	C560_HUMAN	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (QPs-1) (QPs1) (Succinate dehydrogenase complex subunit C) (Succinate-ubiquinone oxidoreductase cytochrome B large subunit) (CYBL)	SDHC CYB560 SDH3	Homo sapiens (Human)	169	FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).		aerobic respiration [GO:0009060]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; tricarboxylic acid cycle [GO:0006099]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [GO:0005749]; mitochondrion [GO:0005739]	electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; succinate dehydrogenase activity [GO:0000104]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [GO:0005749]; mitochondrion [GO:0005739]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; succinate dehydrogenase activity [GO:0000104]; aerobic respiration [GO:0009060]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
Q99645	reviewed	EPYC_HUMAN	Epiphycan (Dermatan sulfate proteoglycan 3) (Proteoglycan-Lb) (PG-Lb) (Small chondroitin/dermatan sulfate proteoglycan)	EPYC DSPG3 PGLB SLRR3B	Homo sapiens (Human)	322	FUNCTION: May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.		articular cartilage development [GO:0061975]; bone development [GO:0060348]; female pregnancy [GO:0007565]; sensory perception of sound [GO:0007605]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	glycosaminoglycan binding [GO:0005539]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; glycosaminoglycan binding [GO:0005539]; articular cartilage development [GO:0061975]; bone development [GO:0060348]; female pregnancy [GO:0007565]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q99650	reviewed	OSMR_HUMAN	Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB)	OSMR OSMRB	Homo sapiens (Human)	979	FUNCTION: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:8999038}.		cytokine-mediated signaling pathway [GO:0019221]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cell population proliferation [GO:0008284]; response to cytokine [GO:0034097]	apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; oncostatin-M receptor complex [GO:0005900]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]	apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; oncostatin-M receptor complex [GO:0005900]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]; cytokine-mediated signaling pathway [GO:0019221]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cell population proliferation [GO:0008284]; response to cytokine [GO:0034097]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q99653	reviewed	CHP1_HUMAN	Calcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22)	CHP1 CHP	Homo sapiens (Human)	195	FUNCTION: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner. {ECO:0000269|PubMed:10593895, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:8901634}.		cellular response to acidic pH [GO:0071468]; cytoplasmic microtubule organization [GO:0031122]; membrane docking [GO:0022406]; membrane fusion [GO:0061025]; membrane organization [GO:0061024]; microtubule bundle formation [GO:0001578]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of phospholipid biosynthetic process [GO:0071073]; positive regulation of protein glycosylation [GO:0060050]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of protein transport [GO:0051222]; positive regulation of sodium:proton antiporter activity [GO:0032417]; potassium ion transport [GO:0006813]; protein export from nucleus [GO:0006611]; protein stabilization [GO:0050821]; regulation of intracellular pH [GO:0051453]; small GTPase mediated signal transduction [GO:0007264]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; transporter complex [GO:1990351]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; potassium channel regulator activity [GO:0015459]; protein kinase inhibitor activity [GO:0004860]; sodium:proton antiporter activity [GO:0015385]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; transporter complex [GO:1990351]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; potassium channel regulator activity [GO:0015459]; protein kinase inhibitor activity [GO:0004860]; sodium:proton antiporter activity [GO:0015385]; cellular response to acidic pH [GO:0071468]; cytoplasmic microtubule organization [GO:0031122]; membrane docking [GO:0022406]; membrane fusion [GO:0061025]; membrane organization [GO:0061024]; microtubule bundle formation [GO:0001578]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of phospholipid biosynthetic process [GO:0071073]; positive regulation of protein glycosylation [GO:0060050]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of protein transport [GO:0051222]; positive regulation of sodium:proton antiporter activity [GO:0032417]; potassium ion transport [GO:0006813]; protein export from nucleus [GO:0006611]; protein stabilization [GO:0050821]; regulation of intracellular pH [GO:0051453]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P61023}. Cytoplasm {ECO:0000250|UniProtKB:P61023}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P61023}. Endomembrane system {ECO:0000250|UniProtKB:P61023}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:P61023}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P61023}. Cell membrane {ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:29379881}. Membrane {ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:29379881}; Lipid-anchor {ECO:0000269|PubMed:25255805}. Note=Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1 at the reticulum endoplasmic and plasma membrane. Colocalizes with STK17B at the plasma membrane. {ECO:0000250|UniProtKB:P61023}.
Q99661	reviewed	KIF2C_HUMAN	Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK)	KIF2C KNSL6	Homo sapiens (Human)	725	FUNCTION: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}.		attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; metaphase chromosome alignment [GO:0051310]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; regulation of chromosome segregation [GO:0051983]	centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]; spindle [GO:0005819]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; centromeric DNA binding [GO:0019237]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule plus-end binding [GO:0051010]	centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]; spindle [GO:0005819]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; centromeric DNA binding [GO:0019237]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule plus-end binding [GO:0051010]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; metaphase chromosome alignment [GO:0051310]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; regulation of chromosome segregation [GO:0051983]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. Nucleus {ECO:0000250|UniProtKB:P70096}. Chromosome, centromere {ECO:0000269|PubMed:14960279, ECO:0000269|PubMed:17485487}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14960279, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:23891108}. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2. {ECO:0000250|UniProtKB:P70096, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:21820309}.
Q99665	reviewed	I12R2_HUMAN	Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)	IL12RB2	Homo sapiens (Human)	862	FUNCTION: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.		cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-12-mediated signaling pathway [GO:0035722]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of type II interferon production [GO:0032729]; response to lipopolysaccharide [GO:0032496]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; protein kinase binding [GO:0019901]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; protein kinase binding [GO:0019901]; cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-12-mediated signaling pathway [GO:0035722]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of type II interferon production [GO:0032729]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q99674	reviewed	CGRE1_HUMAN	Cell growth regulator with EF hand domain protein 1 (Cell growth regulatory gene 11 protein) (Hydrophobestin)	CGREF1 CGR11	Homo sapiens (Human)	318	FUNCTION: Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines. {ECO:0000250}.		cell adhesion [GO:0007155]; cell cycle [GO:0007049]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell cycle [GO:0051726]	extracellular region [GO:0005576]	calcium ion binding [GO:0005509]	extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q99675	reviewed	CGRF1_HUMAN	Cell growth regulator with RING finger domain protein 1 (Cell growth regulatory gene 19 protein) (RING finger protein 197)	CGRRF1 CGR19 RNF197	Homo sapiens (Human)	332	FUNCTION: Able to inhibit growth in several cell lines. {ECO:0000250|UniProtKB:P97587}.		cell cycle [GO:0007049]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell cycle [GO:0051726]	endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]	endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; cell cycle [GO:0007049]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22361696}. Endoplasmic reticulum {ECO:0000269|PubMed:27485036}.
Q99677	reviewed	LPAR4_HUMAN	Lysophosphatidic acid receptor 4 (LPA receptor 4) (LPA-4) (G-protein coupled receptor 23) (P2Y purinoceptor 9) (P2Y9) (P2Y5-like receptor) (Purinergic receptor 9)	LPAR4 GPR23 LPA4 P2RY9	Homo sapiens (Human)	370	FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA. {ECO:0000269|PubMed:12724320}.		phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]	lysophosphatidic acid binding [GO:0035727]; lysophosphatidic acid receptor activity [GO:0070915]	intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; lysophosphatidic acid binding [GO:0035727]; lysophosphatidic acid receptor activity [GO:0070915]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q99683	reviewed	M3K5_HUMAN	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)	MAP3K5 ASK1 MAPKKK5 MEKK5	Homo sapiens (Human)	1374	FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}.		apoptotic signaling pathway [GO:0097190]; cellular response to amino acid starvation [GO:0034198]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive nitrogen species [GO:1902170]; cellular response to tumor necrosis factor [GO:0071356]; cellular senescence [GO:0090398]; endothelial cell apoptotic process [GO:0072577]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; neuron apoptotic process [GO:0051402]; neuron intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0036480]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; programmed necrotic cell death [GO:0097300]; protein phosphorylation [GO:0006468]; response to endoplasmic reticulum stress [GO:0034976]; response to ischemia [GO:0002931]; stress-activated MAPK cascade [GO:0051403]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; IRE1-TRAF2-ASK1 complex [GO:1990604]; protein kinase complex [GO:1902911]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; IRE1-TRAF2-ASK1 complex [GO:1990604]; protein kinase complex [GO:1902911]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic signaling pathway [GO:0097190]; cellular response to amino acid starvation [GO:0034198]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive nitrogen species [GO:1902170]; cellular response to tumor necrosis factor [GO:0071356]; cellular senescence [GO:0090398]; endothelial cell apoptotic process [GO:0072577]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; neuron apoptotic process [GO:0051402]; neuron intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0036480]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; programmed necrotic cell death [GO:0097300]; protein phosphorylation [GO:0006468]; response to endoplasmic reticulum stress [GO:0034976]; response to ischemia [GO:0002931]; stress-activated MAPK cascade [GO:0051403]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26095851}. Endoplasmic reticulum. Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.
Q99684	reviewed	GFI1_HUMAN	Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163)	GFI1 ZNF163	Homo sapiens (Human)	422	FUNCTION: Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells. {ECO:0000250|UniProtKB:P70338, ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:12778173, ECO:0000269|PubMed:16287849, ECO:0000269|PubMed:17197705, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:19026687, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:20190815, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:8754800}.		cellular response to lipopolysaccharide [GO:0071222]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron projection development [GO:0010977]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D biosynthetic process [GO:0010957]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; viral process [GO:0016032]	nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron projection development [GO:0010977]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D biosynthetic process [GO:0010957]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:12874834, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:8754800}. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.
Q99685	reviewed	MGLL_HUMAN	Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL)	MGLL	Homo sapiens (Human)	303	FUNCTION: Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). {ECO:0000269|PubMed:19029917, ECO:0000269|PubMed:20079333, ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842}.	MISCELLANEOUS: Short-term inhibition causes analgesia, while long-term inhibition causes tolerance to endocannabinoids acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1 activity. {ECO:0000250}.	acylglycerol catabolic process [GO:0046464]; arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; monoacylglycerol catabolic process [GO:0052651]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of inflammatory response [GO:0050727]; regulation of sensory perception of pain [GO:0051930]; regulation of signal transduction [GO:0009966]; triglyceride catabolic process [GO:0019433]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	acylglycerol lipase activity [GO:0047372]; lysophospholipase activity [GO:0004622]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; acylglycerol lipase activity [GO:0047372]; lysophospholipase activity [GO:0004622]; protein homodimerization activity [GO:0042803]; acylglycerol catabolic process [GO:0046464]; arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; monoacylglycerol catabolic process [GO:0052651]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of inflammatory response [GO:0050727]; regulation of sensory perception of pain [GO:0051930]; regulation of signal transduction [GO:0009966]; triglyceride catabolic process [GO:0019433]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O35678}. Membrane {ECO:0000250|UniProtKB:O35678}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35678}.
Q99687	reviewed	MEIS3_HUMAN	Homeobox protein Meis3 (Meis1-related protein 2)	MEIS3 MRG2	Homo sapiens (Human)	375	FUNCTION: Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1. {ECO:0000250|UniProtKB:P97368}.		animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; negative regulation of apoptotic signaling pathway [GO:2001234]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; negative regulation of apoptotic signaling pathway [GO:2001234]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P97368}.
Q99689	reviewed	FEZ1_HUMAN	Fasciculation and elongation protein zeta-1 (Zygin I) (Zygin-1)	FEZ1	Homo sapiens (Human)	392	FUNCTION: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. {ECO:0000269|PubMed:20812761, ECO:0000269|PubMed:22354037}.		axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to growth factor stimulus [GO:0071363]; establishment of cell polarity [GO:0030010]; establishment of mitochondrion localization [GO:0051654]; hippocampus development [GO:0021766]; mitochondrion morphogenesis [GO:0070584]; negative regulation of autophagosome assembly [GO:1902902]; nervous system development [GO:0007399]; positive regulation of anterograde axonal transport of mitochondrion [GO:0061881]; positive regulation of neuron projection development [GO:0010976]	axon [GO:0030424]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	gamma-tubulin binding [GO:0043015]; protein kinase C binding [GO:0005080]	axon [GO:0030424]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; gamma-tubulin binding [GO:0043015]; protein kinase C binding [GO:0005080]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to growth factor stimulus [GO:0071363]; establishment of cell polarity [GO:0030010]; establishment of mitochondrion localization [GO:0051654]; hippocampus development [GO:0021766]; mitochondrion morphogenesis [GO:0070584]; negative regulation of autophagosome assembly [GO:1902902]; nervous system development [GO:0007399]; positive regulation of anterograde axonal transport of mitochondrion [GO:0061881]; positive regulation of neuron projection development [GO:0010976]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18439996}. Cell membrane {ECO:0000250}. Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). {ECO:0000250}.
Q99697	reviewed	PITX2_HUMAN	Pituitary homeobox 2 (ALL1-responsive protein ARP1) (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (RIEG bicoid-related homeobox transcription factor) (Solurshin)	PITX2 ARP1 RGS RIEG RIEG1	Homo sapiens (Human)	317	FUNCTION: Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity). {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; camera-type eye development [GO:0043010]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell proliferation involved in outflow tract morphogenesis [GO:0061325]; deltoid tuberosity development [GO:0035993]; determination of left/right symmetry [GO:0007368]; embryonic heart tube left/right pattern formation [GO:0060971]; hair cell differentiation [GO:0035315]; iris morphogenesis [GO:0061072]; left/right axis specification [GO:0070986]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prolactin secreting cell differentiation [GO:0060127]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; somatotropin secreting cell differentiation [GO:0060126]; spleen development [GO:0048536]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; ribonucleoprotein complex binding [GO:0043021]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; ribonucleoprotein complex binding [GO:0043021]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; camera-type eye development [GO:0043010]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell proliferation involved in outflow tract morphogenesis [GO:0061325]; deltoid tuberosity development [GO:0035993]; determination of left/right symmetry [GO:0007368]; embryonic heart tube left/right pattern formation [GO:0060971]; hair cell differentiation [GO:0035315]; iris morphogenesis [GO:0061072]; left/right axis specification [GO:0070986]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prolactin secreting cell differentiation [GO:0060127]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; somatotropin secreting cell differentiation [GO:0060126]; spleen development [GO:0048536]	SUBCELLULAR LOCATION: Nucleus.
Q99698	reviewed	LYST_HUMAN	Lysosomal-trafficking regulator (Beige homolog)	LYST CHS CHS1	Homo sapiens (Human)	3801	FUNCTION: Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.	defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; leukocyte chemotaxis [GO:0030595]; mast cell secretory granule organization [GO:0033364]; melanosome organization [GO:0032438]; natural killer cell mediated cytotoxicity [GO:0042267]; phagocytosis [GO:0006909]; pigmentation [GO:0043473]; protein localization [GO:0008104]; protein transport [GO:0015031]	cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]	protein kinase binding [GO:0019901]	cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; protein kinase binding [GO:0019901]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; leukocyte chemotaxis [GO:0030595]; mast cell secretory granule organization [GO:0033364]; melanosome organization [GO:0032438]; natural killer cell mediated cytotoxicity [GO:0042267]; phagocytosis [GO:0006909]; pigmentation [GO:0043473]; protein localization [GO:0008104]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q99700	reviewed	ATX2_HUMAN	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	ATXN2 ATX2 SCA2 TNRC13	Homo sapiens (Human)	1313	FUNCTION: Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}.		negative regulation of receptor internalization [GO:0002091]; P-body assembly [GO:0033962]; regulation of translation [GO:0006417]; RNA metabolic process [GO:0016070]; RNA transport [GO:0050658]; stress granule assembly [GO:0034063]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; trans-Golgi network [GO:0005802]	epidermal growth factor receptor binding [GO:0005154]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; trans-Golgi network [GO:0005802]; epidermal growth factor receptor binding [GO:0005154]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; negative regulation of receptor internalization [GO:0002091]; P-body assembly [GO:0033962]; regulation of translation [GO:0006417]; RNA metabolic process [GO:0016070]; RNA transport [GO:0050658]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q99704	reviewed	DOK1_HUMAN	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)	DOK1	Homo sapiens (Human)	481	FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}.	MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation at Met-140 of isoform 1. {ECO:0000305}.	cell surface receptor signaling pathway [GO:0007166]; macrophage colony-stimulating factor signaling pathway [GO:0038145]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; cell surface receptor signaling pathway [GO:0007166]; macrophage colony-stimulating factor signaling pathway [GO:0038145]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, perinuclear region.
Q99705	reviewed	MCHR1_HUMAN	Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein)	MCHR1 GPR24 SLC1	Homo sapiens (Human)	422	FUNCTION: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. {ECO:0000269|PubMed:10421367}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cell surface receptor signaling pathway [GO:0007166]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; generation of precursor metabolites and energy [GO:0006091]; neuropeptide signaling pathway [GO:0007218]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; melanin-concentrating hormone receptor activity [GO:0030273]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; signaling receptor binding [GO:0005102]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; melanin-concentrating hormone receptor activity [GO:0030273]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; signaling receptor binding [GO:0005102]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cell surface receptor signaling pathway [GO:0007166]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; generation of precursor metabolites and energy [GO:0006091]; neuropeptide signaling pathway [GO:0007218]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q99706	reviewed	KI2L4_HUMAN	Killer cell immunoglobulin-like receptor 2DL4 (CD158 antigen-like family member D) (G9P) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (MHC class I NK cell receptor KIR103AS) (CD antigen CD158d)	KIR2DL4 CD158D KIR103AS	Homo sapiens (Human)	377	FUNCTION: Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response (PubMed:20179272). {ECO:0000269|PubMed:10190900, ECO:0000269|PubMed:16366734, ECO:0000269|PubMed:20179272, ECO:0000269|PubMed:23184984, ECO:0000269|PubMed:29262349}.		cellular defense response [GO:0006968]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of cellular senescence [GO:2000774]; positive regulation of natural killer cell cytokine production [GO:0002729]; signal transduction [GO:0007165]	early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886]	MHC class Ib receptor activity [GO:0032394]; transmembrane signaling receptor activity [GO:0004888]	early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; MHC class Ib receptor activity [GO:0032394]; transmembrane signaling receptor activity [GO:0004888]; cellular defense response [GO:0006968]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of cellular senescence [GO:2000774]; positive regulation of natural killer cell cytokine production [GO:0002729]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Early endosome membrane {ECO:0000269|PubMed:16366734}.
Q99707	reviewed	METH_HUMAN	Methionine synthase (MS) (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Cobalamin-dependent methionine synthase) (Vitamin-B12 dependent methionine synthase)	MTR	Homo sapiens (Human)	1265	FUNCTION: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol (PubMed:16769880, PubMed:27771510, PubMed:17288554). MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate (PubMed:16769880, PubMed:27771510, PubMed:17288554). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:16769880, PubMed:27771510). {ECO:0000269|PubMed:16769880, ECO:0000269|PubMed:17288554, ECO:0000269|PubMed:27771510}.		axon regeneration [GO:0031103]; cellular response to nitric oxide [GO:0071732]; cobalamin metabolic process [GO:0009235]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; methylation [GO:0032259]; nervous system development [GO:0007399]; response to axon injury [GO:0048678]; tetrahydrofolate metabolic process [GO:0046653]	cytosol [GO:0005829]	cobalamin binding [GO:0031419]; methionine synthase activity [GO:0008705]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; cobalamin binding [GO:0031419]; methionine synthase activity [GO:0008705]; zinc ion binding [GO:0008270]; axon regeneration [GO:0031103]; cellular response to nitric oxide [GO:0071732]; cobalamin metabolic process [GO:0009235]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; methylation [GO:0032259]; nervous system development [GO:0007399]; response to axon injury [GO:0048678]; tetrahydrofolate metabolic process [GO:0046653]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:27771510}.
Q99708	reviewed	CTIP_HUMAN	DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2)	RBBP8 CTIP	Homo sapiens (Human)	897	FUNCTION: Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:26721387). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:30601117}.	MISCELLANEOUS: Binds one Zn(2+) atom per dimer. Zn(2+)-binding is not required for homotetramerization. {ECO:0000269|PubMed:25558984}.	blastocyst hatching [GO:0001835]; cell division [GO:0051301]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair via homologous recombination [GO:0000724]; G1/S transition of mitotic cell cycle [GO:0000082]; homologous recombination [GO:0035825]; meiotic cell cycle [GO:0051321]; mitotic G2/M transition checkpoint [GO:0044818]; regulation of transcription by RNA polymerase II [GO:0006357]	BRCA1-C complex [GO:0070533]; chromosome [GO:0005694]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	damaged DNA binding [GO:0003684]; identical protein binding [GO:0042802]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; transcription corepressor activity [GO:0003714]	BRCA1-C complex [GO:0070533]; chromosome [GO:0005694]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; damaged DNA binding [GO:0003684]; identical protein binding [GO:0042802]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; transcription corepressor activity [GO:0003714]; blastocyst hatching [GO:0001835]; cell division [GO:0051301]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair via homologous recombination [GO:0000724]; G1/S transition of mitotic cell cycle [GO:0000082]; homologous recombination [GO:0035825]; meiotic cell cycle [GO:0051321]; mitotic G2/M transition checkpoint [GO:0044818]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:23623683}. Chromosome {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:29042561}. Note=Associates with sites of DNA damage in S/G2 phase (PubMed:10764811, PubMed:25349192). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604). {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:25349192}.
Q99712	reviewed	KCJ15_HUMAN	ATP-sensitive inward rectifier potassium channel 15 (Inward rectifier K(+) channel Kir1.3) (Inward rectifier K(+) channel Kir4.2) (Potassium channel, inwardly rectifying subfamily J member 15)	KCNJ15 KCNJ14	Homo sapiens (Human)	375	FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.		potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]	plasma membrane [GO:0005886]	inward rectifier potassium channel activity [GO:0005242]	plasma membrane [GO:0005886]; inward rectifier potassium channel activity [GO:0005242]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q99714	reviewed	HCD2_HUMAN	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)	HSD17B10 ERAB HADH2 MRPP2 SCHAD SDR5C1 XH98G2	Homo sapiens (Human)	261	FUNCTION: Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism (PubMed:9553139, PubMed:10600649, PubMed:12917011, PubMed:20077426, PubMed:18996107, PubMed:19706438, PubMed:25925575, PubMed:26950678, PubMed:28888424). Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA (PubMed:9553139, PubMed:10600649, PubMed:12917011, PubMed:25925575, PubMed:26950678). Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway (PubMed:20077426, PubMed:18996107, PubMed:19706438). Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids (PubMed:10600649, PubMed:12917011). Oxidizes allopregnanolone/brexanolone at the 3alpha-hydroxyl group, which is known to be critical for the activation of gamma-aminobutyric acid receptors (GABAARs) chloride channel (PubMed:19706438, PubMed:28888424). Has phospholipase C-like activity toward cardiolipin and its oxidized species. Likely oxidizes the 2'-hydroxyl in the head group of cardiolipin to form a ketone intermediate that undergoes nucleophilic attack by water and fragments into diacylglycerol, dihydroxyacetone and orthophosphate. Has higher affinity for cardiolipin with oxidized fatty acids and may degrade these species during the oxidative stress response to protect cells from apoptosis (PubMed:26338420). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426). {ECO:0000269|PubMed:10600649, ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18996107, ECO:0000269|PubMed:19706438, ECO:0000269|PubMed:20077426, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26338420, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:9553139}.; FUNCTION: In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:24549042, PubMed:25925575, PubMed:26950678, PubMed:28888424). Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit (PubMed:23042678, PubMed:25925575, PubMed:28888424). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24549042, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:29040705}.		androgen metabolic process [GO:0008209]; bile acid biosynthetic process [GO:0006699]; brexanolone metabolic process [GO:0062173]; C21-steroid hormone metabolic process [GO:0008207]; estrogen metabolic process [GO:0008210]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; isoleucine catabolic process [GO:0006550]; lipid metabolic process [GO:0006629]; mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA 5'-end processing [GO:0097745]; mitochondrial tRNA methylation [GO:0070901]; mitochondrion organization [GO:0007005]; protein homotetramerization [GO:0051289]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; tRNA methyltransferase complex [GO:0043527]	17-beta-hydroxysteroid dehydrogenase (NAD+) activity [GO:0044594]; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity [GO:0047015]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity [GO:0106281]; cholate 7-alpha-dehydrogenase activity [GO:0008709]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity [GO:0106282]; RNA binding [GO:0003723]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; testosterone dehydrogenase [NAD(P)] activity [GO:0030283]; tRNA binding [GO:0000049]; ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity [GO:0106283]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; tRNA methyltransferase complex [GO:0043527]; 17-beta-hydroxysteroid dehydrogenase (NAD+) activity [GO:0044594]; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity [GO:0047015]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity [GO:0106281]; cholate 7-alpha-dehydrogenase activity [GO:0008709]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity [GO:0106282]; RNA binding [GO:0003723]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; testosterone dehydrogenase [NAD(P)] activity [GO:0030283]; tRNA binding [GO:0000049]; ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity [GO:0106283]; androgen metabolic process [GO:0008209]; bile acid biosynthetic process [GO:0006699]; brexanolone metabolic process [GO:0062173]; C21-steroid hormone metabolic process [GO:0008207]; estrogen metabolic process [GO:0008210]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; isoleucine catabolic process [GO:0006550]; lipid metabolic process [GO:0006629]; mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA 5'-end processing [GO:0097745]; mitochondrial tRNA methylation [GO:0070901]; mitochondrion organization [GO:0007005]; protein homotetramerization [GO:0051289]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18984158}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:24703694}.
Q99715	reviewed	COCA1_HUMAN	Collagen alpha-1(XII) chain	COL12A1 COL12A1L	Homo sapiens (Human)	3063	FUNCTION: Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. {ECO:0000250}.		cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987]	collagen type XII trimer [GO:0005595]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen type XII trimer [GO:0005595]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q99717	reviewed	SMAD5_HUMAN	Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5)	SMAD5 MADH5	Homo sapiens (Human)	465	FUNCTION: Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:16516194, PubMed:12064918). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}.		anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cardiac conduction system development [GO:0003161]; cardiac muscle contraction [GO:0060048]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cellular response to organic cyclic compound [GO:0071407]; embryonic pattern specification [GO:0009880]; erythrocyte differentiation [GO:0030218]; germ cell development [GO:0007281]; Mullerian duct regression [GO:0001880]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Fas signaling pathway [GO:1902045]; negative regulation of gene expression [GO:0010629]; osteoblast differentiation [GO:0001649]; osteoblast fate commitment [GO:0002051]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SMAD protein complex [GO:0071141]	DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SMAD protein complex [GO:0071141]; DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; ubiquitin protein ligase binding [GO:0031625]; anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cardiac conduction system development [GO:0003161]; cardiac muscle contraction [GO:0060048]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cellular response to organic cyclic compound [GO:0071407]; embryonic pattern specification [GO:0009880]; erythrocyte differentiation [GO:0030218]; germ cell development [GO:0007281]; Mullerian duct regression [GO:0001880]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Fas signaling pathway [GO:1902045]; negative regulation of gene expression [GO:0010629]; osteoblast differentiation [GO:0001649]; osteoblast fate commitment [GO:0002051]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:9442019}. Nucleus {ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:9442019}. Mitochondrion {ECO:0000269|PubMed:12849988}. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. {ECO:0000269|PubMed:9442019}.
Q99719	reviewed	SEPT5_HUMAN	Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1)	SEPTIN5 PNUTL1 SEPT5	Homo sapiens (Human)	369	FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity). {ECO:0000250, ECO:0000305}.	MISCELLANEOUS: In a heterologous system, SEPTIN5 overexpression has been shown to exert dopamine-dependent neurotoxicity. As wild-type PRKN, but not familial-linked PRKN mutants, ubiquitinates mouse SEPTIN5 and promotes its degradation, it has been suggested that a deficiency in SEPTIN5 degradation may contribute to the development of early onset Parkinson disease 2 (PARK2).	adult behavior [GO:0030534]; cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle exocytosis [GO:2000300]; social behavior [GO:0035176]; synaptic vesicle targeting [GO:0016080]	cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; septin complex [GO:0031105]; septin ring [GO:0005940]; synaptic vesicle [GO:0008021]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198]	cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; septin complex [GO:0031105]; septin ring [GO:0005940]; synaptic vesicle [GO:0008021]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198]; adult behavior [GO:0030534]; cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle exocytosis [GO:2000300]; social behavior [GO:0035176]; synaptic vesicle targeting [GO:0016080]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In platelets, found in areas surrounding alpha-granules.
Q99720	reviewed	SGMR1_HUMAN	Sigma non-opioid intracellular receptor 1 (Aging-associated gene 8 protein) (SR31747-binding protein) (SR-BP) (Sigma 1-type opioid receptor) (SIG-1R) (Sigma1-receptor) (Sigma1R) (hSigmaR1)	SIGMAR1 OPRS1 SRBP AAG8	Homo sapiens (Human)	223	FUNCTION: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity). {ECO:0000250|UniProtKB:O55242, ECO:0000269|PubMed:16472803, ECO:0000269|PubMed:9341151}.	MISCELLANEOUS: Depletion by RNAi inhibits growth and survival signaling cascades and induces cell death. The antagonist rimcazole produces the same effect.; MISCELLANEOUS: Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile. {ECO:0000303|PubMed:22292588}.	lipid transport [GO:0006869]; nervous system development [GO:0007399]; protein homotrimerization [GO:0070207]; regulation of neuron apoptotic process [GO:0043523]	anchoring junction [GO:0070161]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; growth cone [GO:0030426]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]	G protein-coupled opioid receptor activity [GO:0004985]; identical protein binding [GO:0042802]	anchoring junction [GO:0070161]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; growth cone [GO:0030426]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; G protein-coupled opioid receptor activity [GO:0004985]; identical protein binding [GO:0042802]; lipid transport [GO:0006869]; nervous system development [GO:0007399]; protein homotrimerization [GO:0070207]; regulation of neuron apoptotic process [GO:0043523]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:10406945}. Nucleus outer membrane {ECO:0000269|PubMed:10406945}. Nucleus envelope {ECO:0000269|PubMed:11476895, ECO:0000269|PubMed:9341151}. Cytoplasmic vesicle {ECO:0000269|PubMed:10406945}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10406945}. Membrane {ECO:0000269|PubMed:11476895, ECO:0000269|PubMed:27042935, ECO:0000269|PubMed:9341151}; Single-pass membrane protein {ECO:0000269|PubMed:27042935}. Lipid droplet {ECO:0000250|UniProtKB:O55242}. Cell junction. Cell membrane {ECO:0000269|PubMed:23314020}. Cell projection, growth cone. Postsynaptic density membrane {ECO:0000269|PubMed:23314020}. Note=During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis (PubMed:10406945). Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Accumulation at the endoplasmic reticulum is prominent in alpha-motor neurons of patients with amyotrophic lateral sclerosis (PubMed:23314020). Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. In motor neurons it is enriched at cholinergic postsynaptic densities (By similarity). {ECO:0000250|UniProtKB:O55242, ECO:0000269|PubMed:10406945, ECO:0000269|PubMed:23314020}.
Q99726	reviewed	ZNT3_HUMAN	Probable proton-coupled zinc antiporter SLC30A3 (Solute carrier family 30 member 3) (Zinc transporter 3) (ZnT-3)	SLC30A3 ZNT3	Homo sapiens (Human)	388	FUNCTION: Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain. {ECO:0000269|PubMed:17349999, ECO:0000269|PubMed:19521526, ECO:0000269|PubMed:26647834}.		positive regulation of transport [GO:0051050]; regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043]; zinc ion import into synaptic vesicle [GO:0099180]; zinc ion transmembrane transport [GO:0071577]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber [GO:0097457]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	antiporter activity [GO:0015297]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber [GO:0097457]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; antiporter activity [GO:0015297]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385]; positive regulation of transport [GO:0051050]; regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043]; zinc ion import into synaptic vesicle [GO:0099180]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305|PubMed:26647834}; Multi-pass membrane protein {ECO:0000255}. Synapse, synaptosome {ECO:0000250|UniProtKB:P97441}. Late endosome membrane {ECO:0000269|PubMed:17349999}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17349999}; Multi-pass membrane protein {ECO:0000255}.
Q99728	reviewed	BARD1_HUMAN	BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)	BARD1	Homo sapiens (Human)	777	FUNCTION: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}.		cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; homologous recombination [GO:0035825]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle [GO:0045786]; negative regulation of mRNA 3'-end processing [GO:0031441]; negative regulation of protein export from nucleus [GO:0046826]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein catabolic process [GO:0045732]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; regulation of phosphorylation [GO:0042325]; tissue homeostasis [GO:0001894]	BRCA1-A complex [GO:0070531]; BRCA1-B complex [GO:0070532]; BRCA1-BARD1 complex [GO:0031436]; BRCA1-C complex [GO:0070533]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; ubiquitin-protein transferase activity [GO:0004842]	BRCA1-A complex [GO:0070531]; BRCA1-B complex [GO:0070532]; BRCA1-BARD1 complex [GO:0031436]; BRCA1-C complex [GO:0070533]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; homologous recombination [GO:0035825]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle [GO:0045786]; negative regulation of mRNA 3'-end processing [GO:0031441]; negative regulation of protein export from nucleus [GO:0046826]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein catabolic process [GO:0045732]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; regulation of phosphorylation [GO:0042325]; tissue homeostasis [GO:0001894]	SUBCELLULAR LOCATION: Nucleus. Note=During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.
Q99729	reviewed	ROAA_HUMAN	Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1)	HNRNPAB ABBP1 HNRPAB	Homo sapiens (Human)	332	FUNCTION: Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.		epithelial to mesenchymal transition [GO:0001837]; mRNA modification [GO:0016556]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; positive regulation of DNA demethylation [GO:1901537]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA polymerase II transcription regulator complex [GO:0090575]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA polymerase II transcription regulator complex [GO:0090575]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; epithelial to mesenchymal transition [GO:0001837]; mRNA modification [GO:0016556]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; positive regulation of DNA demethylation [GO:1901537]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17289661}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Q99731	reviewed	CCL19_HUMAN	C-C motif chemokine 19 (Beta-chemokine exodus-3) (CK beta-11) (Epstein-Barr virus-induced molecule 1 ligand chemokine) (EBI1 ligand chemokine) (ELC) (Macrophage inflammatory protein 3 beta) (MIP-3-beta) (Small-inducible cytokine A19)	CCL19 ELC MIP3B SCYA19	Homo sapiens (Human)	98	FUNCTION: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. {ECO:0000269|PubMed:9498785}.		cell communication [GO:0007154]; cell maturation [GO:0048469]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cellular response to virus [GO:0098586]; chemokine-mediated signaling pathway [GO:0070098]; dendritic cell chemotaxis [GO:0002407]; establishment of T cell polarity [GO:0001768]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; immunological synapse formation [GO:0001771]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; mature conventional dendritic cell differentiation [GO:0097029]; monocyte chemotaxis [GO:0002548]; myeloid dendritic cell chemotaxis [GO:0002408]; negative regulation of dendritic cell apoptotic process [GO:2000669]; neutrophil chemotaxis [GO:0030593]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell motility [GO:2000147]; positive regulation of chemotaxis [GO:0050921]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of dendritic cell dendrite assembly [GO:2000549]; positive regulation of endocytosis [GO:0045807]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glycoprotein biosynthetic process [GO:0010560]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell projection assembly [GO:0060491]; release of sequestered calcium ion into cytosol [GO:0051209]; response to nitric oxide [GO:0071731]; response to prostaglandin E [GO:0034695]; response to virus [GO:0009615]; T cell costimulation [GO:0031295]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR10 chemokine receptor binding [GO:0031735]; CCR7 chemokine receptor binding [GO:0031732]; chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR10 chemokine receptor binding [GO:0031735]; CCR7 chemokine receptor binding [GO:0031732]; chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]; cell communication [GO:0007154]; cell maturation [GO:0048469]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cellular response to virus [GO:0098586]; chemokine-mediated signaling pathway [GO:0070098]; dendritic cell chemotaxis [GO:0002407]; establishment of T cell polarity [GO:0001768]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; immunological synapse formation [GO:0001771]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; mature conventional dendritic cell differentiation [GO:0097029]; monocyte chemotaxis [GO:0002548]; myeloid dendritic cell chemotaxis [GO:0002408]; negative regulation of dendritic cell apoptotic process [GO:2000669]; neutrophil chemotaxis [GO:0030593]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell motility [GO:2000147]; positive regulation of chemotaxis [GO:0050921]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of dendritic cell dendrite assembly [GO:2000549]; positive regulation of endocytosis [GO:0045807]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glycoprotein biosynthetic process [GO:0010560]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell projection assembly [GO:0060491]; release of sequestered calcium ion into cytosol [GO:0051209]; response to nitric oxide [GO:0071731]; response to prostaglandin E [GO:0034695]; response to virus [GO:0009615]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: Secreted.
Q99732	reviewed	LITAF_HUMAN	Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)	LITAF PIG7 SIMPLE	Homo sapiens (Human)	161	FUNCTION: Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352). Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429). May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005). {ECO:0000269|PubMed:15793005, ECO:0000269|PubMed:23166352, ECO:0000303|PubMed:15776429, ECO:0000305|PubMed:10200294}.	MISCELLANEOUS: [Isoform 2]: May be due to a frameshift that creates an unconventional splicing site. Data inferred from this isoform must be interpreted with caution. {ECO:0000305}.	cellular response to lipopolysaccharide [GO:0071222]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production [GO:0001817]; regulation of macrophage cytokine production [GO:0010935]	cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytoplasmic side of plasma membrane [GO:0009898]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270]	cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytoplasmic side of plasma membrane [GO:0009898]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production [GO:0001817]; regulation of macrophage cytokine production [GO:0010935]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15793005}. Nucleus {ECO:0000269|PubMed:15793005, ECO:0000269|PubMed:16954198}. Lysosome membrane {ECO:0000269|PubMed:11274176, ECO:0000269|PubMed:27582497}; Peripheral membrane protein {ECO:0000269|PubMed:11274176}; Cytoplasmic side {ECO:0000269|PubMed:11274176}. Early endosome membrane {ECO:0000269|PubMed:21896645, ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:27582497}. Late endosome membrane {ECO:0000269|PubMed:27582497}. Endosome membrane {ECO:0000269|PubMed:27927196}; Peripheral membrane protein {ECO:0000269|PubMed:27927196}; Cytoplasmic side {ECO:0000269|PubMed:27927196}. Cell membrane {ECO:0000269|PubMed:16118794, ECO:0000269|PubMed:27582497}; Peripheral membrane protein {ECO:0000269|PubMed:27582497}; Cytoplasmic side {ECO:0000269|PubMed:27582497}. Golgi apparatus membrane {ECO:0000269|PubMed:16118794}. Note=Associated with membranes of lysosomes, early and late endosomes (PubMed:11274176, PubMed:27927196, PubMed:27582497). Can translocate from the cytoplasm into the nucleus (PubMed:15793005). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity). {ECO:0000250|UniProtKB:Q9JLJ0, ECO:0000269|PubMed:11274176, ECO:0000269|PubMed:15793005, ECO:0000269|PubMed:27582497, ECO:0000269|PubMed:27927196}.
Q99733	reviewed	NP1L4_HUMAN	Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2)	NAP1L4 NAP2	Homo sapiens (Human)	375	FUNCTION: Acts as histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}.		nucleosome assembly [GO:0006334]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10764593, ECO:0000269|PubMed:9325046}. Cytoplasm {ECO:0000269|PubMed:10764593, ECO:0000269|PubMed:9325046}. Note=Present in the cytoplasm and excluded from the nucleus during G0/G1 phase, then relocates to the nucleus by the time cells are in S phase (PubMed:9325046). Phosphorylated form localizes in the cytoplasm during the G0/G1 transition, whereas dephosphorylation leads to relocalization into the nucleus at the G1/S-boundary (PubMed:10764593). {ECO:0000269|PubMed:10764593, ECO:0000269|PubMed:9325046}.
Q99735	reviewed	MGST2_HUMAN	Microsomal glutathione S-transferase 2 (Microsomal GST-2) (EC 2.5.1.18) (Glutathione peroxidase MGST2) (EC 1.11.1.-) (Leukotriene C4 synthase MGST2) (EC 4.4.1.20) (Microsomal glutathione S-transferase II) (Microsomal GST-II)	MGST2 GST2	Homo sapiens (Human)	147	FUNCTION: Catalyzes several different glutathione-dependent reactions (PubMed:8703034, PubMed:9278457, PubMed:23409838, PubMed:26656251, PubMed:26066610). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed:9278457, PubMed:23409838). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed:23409838, PubMed:8703034). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed:23409838, PubMed:26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251). {ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:26066610, ECO:0000269|PubMed:26656251, ECO:0000269|PubMed:8703034, ECO:0000269|PubMed:9278457}.		glutathione biosynthetic process [GO:0006750]; leukotriene biosynthetic process [GO:0019370]; lipid metabolic process [GO:0006629]; membrane lipid catabolic process [GO:0046466]; positive regulation of inflammatory response [GO:0050729]; response to lipopolysaccharide [GO:0032496]; response to organonitrogen compound [GO:0010243]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]	enzyme activator activity [GO:0008047]; glutathione binding [GO:0043295]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; enzyme activator activity [GO:0008047]; glutathione binding [GO:0043295]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464]; glutathione biosynthetic process [GO:0006750]; leukotriene biosynthetic process [GO:0019370]; lipid metabolic process [GO:0006629]; membrane lipid catabolic process [GO:0046466]; positive regulation of inflammatory response [GO:0050729]; response to lipopolysaccharide [GO:0032496]; response to organonitrogen compound [GO:0010243]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:8703034}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:8703034}; Multi-pass membrane protein {ECO:0000255}.
Q99741	reviewed	CDC6_HUMAN	Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6)	CDC6 CDC18L	Homo sapiens (Human)	560	FUNCTION: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.		cell division [GO:0051301]; cellular response to angiotensin [GO:1904385]; cellular response to vasopressin [GO:1904117]; DNA replication checkpoint signaling [GO:0000076]; DNA replication initiation [GO:0006270]; mitotic DNA replication checkpoint signaling [GO:0033314]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of cytokinesis [GO:0032467]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; traversing start control point of mitotic cell cycle [GO:0007089]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; kinase binding [GO:0019900]; nucleotide binding [GO:0000166]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; kinase binding [GO:0019900]; nucleotide binding [GO:0000166]; cell division [GO:0051301]; cellular response to angiotensin [GO:1904385]; cellular response to vasopressin [GO:1904117]; DNA replication checkpoint signaling [GO:0000076]; DNA replication initiation [GO:0006270]; mitotic DNA replication checkpoint signaling [GO:0033314]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of cytokinesis [GO:0032467]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; traversing start control point of mitotic cell cycle [GO:0007089]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26818844, ECO:0000269|PubMed:9566895}. Cytoplasm {ECO:0000269|PubMed:9566895}. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895). {ECO:0000269|PubMed:9566895}.
Q99743	reviewed	NPAS2_HUMAN	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Basic-helix-loop-helix-PAS protein MOP4) (Class E basic helix-loop-helix protein 9) (bHLHe9) (Member of PAS protein 4) (PAS domain-containing protein 4)	NPAS2 BHLHE9 MOP4 PASD4	Homo sapiens (Human)	824	FUNCTION: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes. Controls the circadian rhythm of NR0B2 expression by binding rhythmically to its promoter (By similarity). Mediates the diurnal variation in the expression of GABARA1 receptor in the brain and contributes to the regulation of anxiety-like behaviors and GABAergic neurotransmission in the ventral striatum (By similarity). {ECO:0000250|UniProtKB:P97460, ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:11441147, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18439826, ECO:0000269|PubMed:18819933}.		central nervous system development [GO:0007417]; circadian regulation of gene expression [GO:0032922]; DNA damage response [GO:0006974]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; response to redox state [GO:0051775]; response to xenobiotic stimulus [GO:0009410]	chromatin [GO:0000785]; CLOCK-BMAL transcription complex [GO:1990513]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; CLOCK-BMAL transcription complex [GO:1990513]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; central nervous system development [GO:0007417]; circadian regulation of gene expression [GO:0032922]; DNA damage response [GO:0006974]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; response to redox state [GO:0051775]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:14645221}.
Q99747	reviewed	SNAG_HUMAN	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein gamma)	NAPG SNAPG	Homo sapiens (Human)	312	FUNCTION: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.		intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; protein stabilization [GO:0050821]; protein-containing complex assembly [GO:0065003]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; SNARE complex [GO:0031201]	soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; SNARE complex [GO:0031201]; soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; protein stabilization [GO:0050821]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P81127}; Peripheral membrane protein {ECO:0000250|UniProtKB:P81127}. Golgi apparatus {ECO:0000250|UniProtKB:Q9CWZ7}.
Q99748	reviewed	NRTN_HUMAN	Neurturin	NRTN	Homo sapiens (Human)	197	FUNCTION: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.		MAPK cascade [GO:0000165]; nerve development [GO:0021675]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neuron projection development [GO:0031175]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	axon [GO:0030424]; extracellular region [GO:0005576]	glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]	axon [GO:0030424]; extracellular region [GO:0005576]; glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; MAPK cascade [GO:0000165]; nerve development [GO:0021675]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neuron projection development [GO:0031175]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Secreted.
Q99750	reviewed	MDFI_HUMAN	MyoD family inhibitor (Myogenic repressor I-mf)	MDFI	Homo sapiens (Human)	246	FUNCTION: Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity). {ECO:0000250}.		cytoplasmic sequestering of transcription factor [GO:0042994]; dorsal/ventral axis specification [GO:0009950]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of DNA binding [GO:0043392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; trophoblast giant cell differentiation [GO:0060707]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; transcription regulator inhibitor activity [GO:0140416]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; transcription regulator inhibitor activity [GO:0140416]; cytoplasmic sequestering of transcription factor [GO:0042994]; dorsal/ventral axis specification [GO:0009950]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of DNA binding [GO:0043392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; trophoblast giant cell differentiation [GO:0060707]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q99755	reviewed	PI51A_HUMAN	Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha)	PIP5K1A	Homo sapiens (Human)	562	FUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:8955136, PubMed:21477596, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197). {ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:19158393, ECO:0000269|PubMed:20660631, ECO:0000269|PubMed:21477596, ECO:0000269|PubMed:22942276, ECO:0000269|PubMed:8955136}.		actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; fibroblast migration [GO:0010761]; focal adhesion assembly [GO:0048041]; glycerophospholipid metabolic process [GO:0006650]; keratinocyte differentiation [GO:0030216]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phospholipid biosynthetic process [GO:0008654]; phosphorylation [GO:0016310]; protein localization to plasma membrane [GO:0072659]; ruffle assembly [GO:0097178]; signal transduction [GO:0007165]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; kinase binding [GO:0019900]; phosphatidylinositol kinase activity [GO:0052742]	cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; 1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; kinase binding [GO:0019900]; phosphatidylinositol kinase activity [GO:0052742]; actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; fibroblast migration [GO:0010761]; focal adhesion assembly [GO:0048041]; glycerophospholipid metabolic process [GO:0006650]; keratinocyte differentiation [GO:0030216]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phospholipid biosynthetic process [GO:0008654]; phosphorylation [GO:0016310]; protein localization to plasma membrane [GO:0072659]; ruffle assembly [GO:0097178]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P70182}. Cytoplasm {ECO:0000250|UniProtKB:P70182}. Nucleus {ECO:0000269|PubMed:15157668}. Nucleus speckle {ECO:0000269|PubMed:18288197}. Cell projection, ruffle {ECO:0000269|PubMed:20660631}. Cell projection, lamellipodium {ECO:0000269|PubMed:15157668}. Note=Colocalizes with RAC1 at actin-rich membrane ruffles (PubMed:20660631). Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs (PubMed:18288197). {ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:20660631}.
Q99757	reviewed	THIOM_HUMAN	Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)	TXN2 TRX2	Homo sapiens (Human)	166	FUNCTION: Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity. {ECO:0000269|PubMed:12032145, ECO:0000269|PubMed:12080052, ECO:0000269|PubMed:26626369}.		cell redox homeostasis [GO:0045454]; cellular response to nutrient levels [GO:0031669]; response to axon injury [GO:0048678]; response to glucose [GO:0009749]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]	dendrite [GO:0030425]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]	peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113]; protein-containing complex binding [GO:0044877]; protein-disulfide reductase activity [GO:0015035]	dendrite [GO:0030425]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113]; protein-containing complex binding [GO:0044877]; protein-disulfide reductase activity [GO:0015035]; cell redox homeostasis [GO:0045454]; cellular response to nutrient levels [GO:0031669]; response to axon injury [GO:0048678]; response to glucose [GO:0009749]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12032145, ECO:0000269|PubMed:12080052}.
Q99758	reviewed	ABCA3_HUMAN	Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ABC-C transporter) (ATP-binding cassette sub-family A member 3) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form]	ABCA3 ABC3	Homo sapiens (Human)	1704	FUNCTION: Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783, PubMed:17574245, PubMed:28887056, PubMed:31473345, PubMed:27177387). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:27177387). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (PubMed:26903515, PubMed:25817392, PubMed:27177387). {ECO:0000269|PubMed:16959783, ECO:0000269|PubMed:17574245, ECO:0000269|PubMed:25817392, ECO:0000269|PubMed:26903515, ECO:0000269|PubMed:27177387, ECO:0000269|PubMed:28887056, ECO:0000269|PubMed:31473345}.		lipid transport [GO:0006869]; lung development [GO:0030324]; organelle assembly [GO:0070925]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid homeostasis [GO:0055091]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of protein homooligomerization [GO:0032464]; protein metabolic process [GO:0019538]; regulation of lipid biosynthetic process [GO:0046890]; regulation of phosphatidylcholine metabolic process [GO:0150172]; response to glucocorticoid [GO:0051384]; response to xenobiotic stimulus [GO:0009410]; surfactant homeostasis [GO:0043129]; xenobiotic export from cell [GO:0046618]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	alveolar lamellar body [GO:0097208]; alveolar lamellar body membrane [GO:0097233]; cytoplasmic vesicle membrane [GO:0030659]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lamellar body [GO:0042599]; lamellar body membrane [GO:0097232]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]	ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine transfer activity [GO:0120019]	alveolar lamellar body [GO:0097208]; alveolar lamellar body membrane [GO:0097233]; cytoplasmic vesicle membrane [GO:0030659]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lamellar body [GO:0042599]; lamellar body membrane [GO:0097232]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine transfer activity [GO:0120019]; lipid transport [GO:0006869]; lung development [GO:0030324]; organelle assembly [GO:0070925]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid homeostasis [GO:0055091]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of protein homooligomerization [GO:0032464]; protein metabolic process [GO:0019538]; regulation of lipid biosynthetic process [GO:0046890]; regulation of phosphatidylcholine metabolic process [GO:0150172]; response to glucocorticoid [GO:0051384]; response to xenobiotic stimulus [GO:0009410]; surfactant homeostasis [GO:0043129]; xenobiotic export from cell [GO:0046618]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Endosome, multivesicular body membrane {ECO:0000269|PubMed:16959783, ECO:0000269|PubMed:20863830, ECO:0000269|PubMed:27177387}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16959783, ECO:0000269|PubMed:17574245, ECO:0000269|PubMed:20863830, ECO:0000269|PubMed:22673903, ECO:0000269|PubMed:27177387, ECO:0000269|PubMed:31473345}. Late endosome membrane {ECO:0000269|PubMed:27177387}. Lysosome membrane {ECO:0000269|PubMed:16959783, ECO:0000269|PubMed:17574245, ECO:0000269|PubMed:20863830, ECO:0000269|PubMed:24142515}. Note=Localized in the limiting membrane of lamellar bodies in lung alveolar type II cells (PubMed:22673903, PubMed:16959783, PubMed:24142515, PubMed:27177387, PubMed:11718719). Trafficks via the Golgi, sorting vesicles (SVs) and late endosome/multivesicular body network directly to the outer membrane of lamellar bodies in AT2 lung epithelial cells or to lysosomes and lysosomal-related organelles (LROs) in other cells where undergoes proteolytic cleavage and oligosaccharide processing from high mannose type to complex type (PubMed:24142515, PubMed:20863830, PubMed:16959783, PubMed:27177387). Oligomers formation takes place in a post-endoplasmic reticulum compartment (PubMed:27352740). {ECO:0000269|PubMed:11718719, ECO:0000269|PubMed:16959783, ECO:0000269|PubMed:20863830, ECO:0000269|PubMed:22673903, ECO:0000269|PubMed:24142515, ECO:0000269|PubMed:27177387, ECO:0000269|PubMed:27352740}.
Q99759	reviewed	M3K3_HUMAN	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)	MAP3K3 MAPKKK3 MEKK3	Homo sapiens (Human)	626	FUNCTION: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:9006902}.		blood vessel development [GO:0001568]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of cellular senescence [GO:2000773]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of p38MAPK cascade [GO:1900745]; protein autophosphorylation [GO:0046777]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; blood vessel development [GO:0001568]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of cellular senescence [GO:2000773]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of p38MAPK cascade [GO:1900745]; protein autophosphorylation [GO:0046777]	
Q99766	reviewed	ATP5S_HUMAN	ATP synthase subunit s, mitochondrial (ATP synthase-coupling factor B) (FB) (Distal membrane arm assembly complex 2-like protein) (Mitochondrial ATP synthase regulatory component factor B)	DMAC2L ATP5S ATPW	Homo sapiens (Human)	215	FUNCTION: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway. {ECO:0000250|UniProtKB:P22027}.		ATP biosynthetic process [GO:0006754]; proton transmembrane transport [GO:1902600]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]	metal ion binding [GO:0046872]; proton transmembrane transporter activity [GO:0015078]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]; metal ion binding [GO:0046872]; proton transmembrane transporter activity [GO:0015078]; ATP biosynthetic process [GO:0006754]; proton transmembrane transport [GO:1902600]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P22027}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P22027}.
Q99767	reviewed	APBA2_HUMAN	Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2)	APBA2 MINT2 X11L	Homo sapiens (Human)	749	FUNCTION: Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.		chemical synaptic transmission [GO:0007268]; in utero embryonic development [GO:0001701]; locomotory behavior [GO:0007626]; multicellular organism growth [GO:0035264]; nervous system development [GO:0007399]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein transport [GO:0015031]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]	amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; chemical synaptic transmission [GO:0007268]; in utero embryonic development [GO:0001701]; locomotory behavior [GO:0007626]; multicellular organism growth [GO:0035264]; nervous system development [GO:0007399]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein transport [GO:0015031]; regulation of gene expression [GO:0010468]	
Q99784	reviewed	NOE1_HUMAN	Noelin (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1)	OLFM1 NOE1 NOEL1	Homo sapiens (Human)	485	FUNCTION: Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity). {ECO:0000250|UniProtKB:O88998, ECO:0000250|UniProtKB:Q9IAK4}.		atrioventricular valve formation [GO:0003190]; cardiac epithelial to mesenchymal transition [GO:0060317]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; neuronal signal transduction [GO:0023041]; positive regulation of apoptotic process [GO:0043065]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; regulation of axon extension [GO:0030516]; signal transduction [GO:0007165]	axon [GO:0030424]; axonal growth cone [GO:0044295]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; synapse [GO:0045202]		axon [GO:0030424]; axonal growth cone [GO:0044295]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; synapse [GO:0045202]; atrioventricular valve formation [GO:0003190]; cardiac epithelial to mesenchymal transition [GO:0060317]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; neuronal signal transduction [GO:0023041]; positive regulation of apoptotic process [GO:0043065]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; regulation of axon extension [GO:0030516]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O88998}. Synapse {ECO:0000250|UniProtKB:O88998}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O88998}. Cell projection, axon {ECO:0000250|UniProtKB:O88998}. Perikaryon {ECO:0000250|UniProtKB:O88998}.
Q99788	reviewed	CML1_HUMAN	Chemerin-like receptor 1 (Chemokine-like receptor 1) (G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ)	CMKLR1 CHEMR23 DEZ	Homo sapiens (Human)	373	FUNCTION: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis (PubMed:27716822). Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:20044979, ECO:0000269|PubMed:27716822}.; FUNCTION: (Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). {ECO:0000269|PubMed:9603476}.	MISCELLANEOUS: [Isoform A]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.	chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of macrophage chemotaxis [GO:0010759]; regulation of calcium-mediated signaling [GO:0050848]; skeletal system development [GO:0001501]	membrane [GO:0016020]; plasma membrane [GO:0005886]	adipokinetic hormone binding [GO:0097004]; adipokinetic hormone receptor activity [GO:0097003]; chemokine receptor activity [GO:0004950]; complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023]	membrane [GO:0016020]; plasma membrane [GO:0005886]; adipokinetic hormone binding [GO:0097004]; adipokinetic hormone receptor activity [GO:0097003]; chemokine receptor activity [GO:0004950]; complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of macrophage chemotaxis [GO:0010759]; regulation of calcium-mediated signaling [GO:0050848]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:16863918, ECO:0000269|PubMed:27716822}; Multi-pass membrane protein {ECO:0000255}. Note=Internalizes efficiently in response to RARRES2. {ECO:0000269|PubMed:27716822}.
Q99795	reviewed	GPA33_HUMAN	Cell surface A33 antigen (Glycoprotein A33)	GPA33	Homo sapiens (Human)	319	FUNCTION: May play a role in cell-cell recognition and signaling.			extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q99797	reviewed	MIPEP_HUMAN	Mitochondrial intermediate peptidase (MIP) (EC 3.4.24.59)	MIPEP MIP	Homo sapiens (Human)	713	FUNCTION: Cleaves proteins, imported into the mitochondrion, to their mature size.		peptide metabolic process [GO:0006518]; protein processing involved in protein targeting to mitochondrion [GO:0006627]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptide metabolic process [GO:0006518]; protein processing involved in protein targeting to mitochondrion [GO:0006627]	SUBCELLULAR LOCATION: Mitochondrion matrix.
Q99798	reviewed	ACON_HUMAN	Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)	ACO2	Homo sapiens (Human)	780	FUNCTION: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}.		citrate metabolic process [GO:0006101]; generation of precursor metabolites and energy [GO:0006091]; isocitrate metabolic process [GO:0006102]; liver development [GO:0001889]; response to isolation stress [GO:0035900]; tricarboxylic acid cycle [GO:0006099]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; citrate dehydratase activity [GO:0047780]; iron ion binding [GO:0005506]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; citrate dehydratase activity [GO:0047780]; iron ion binding [GO:0005506]; citrate metabolic process [GO:0006101]; generation of precursor metabolites and energy [GO:0006091]; isocitrate metabolic process [GO:0006102]; liver development [GO:0001889]; response to isolation stress [GO:0035900]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P16276}.
Q99801	reviewed	NKX31_HUMAN	Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A)	NKX3-1 NKX3.1 NKX3A	Homo sapiens (Human)	234	FUNCTION: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; androgen receptor signaling pathway [GO:0030521]; branching involved in prostate gland morphogenesis [GO:0060442]; branching morphogenesis of an epithelial tube [GO:0048754]; cell differentiation [GO:0030154]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage response [GO:0006974]; dorsal aorta development [GO:0035907]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; heart development [GO:0007507]; male gonad development [GO:0008584]; metanephros development [GO:0001656]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; pharyngeal system development [GO:0060037]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of androgen secretion [GO:2000836]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; salivary gland development [GO:0007431]; somitogenesis [GO:0001756]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; MADS box domain binding [GO:0097162]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor activity [GO:0004879]; protein self-association [GO:0043621]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription regulator inhibitor activity [GO:0140416]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; MADS box domain binding [GO:0097162]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor activity [GO:0004879]; protein self-association [GO:0043621]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription regulator inhibitor activity [GO:0140416]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; androgen receptor signaling pathway [GO:0030521]; branching involved in prostate gland morphogenesis [GO:0060442]; branching morphogenesis of an epithelial tube [GO:0048754]; cell differentiation [GO:0030154]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage response [GO:0006974]; dorsal aorta development [GO:0035907]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; heart development [GO:0007507]; male gonad development [GO:0008584]; metanephros development [GO:0001656]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; pharyngeal system development [GO:0060037]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of androgen secretion [GO:2000836]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; salivary gland development [GO:0007431]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11137288}.
Q99807	reviewed	COQ7_HUMAN	5-demethoxyubiquinone hydroxylase, mitochondrial (DMQ hydroxylase) (EC 1.14.99.60) (Timing protein clk-1 homolog) (Ubiquinone biosynthesis monooxygenase COQ7)	COQ7	Homo sapiens (Human)	217	FUNCTION: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis (By similarity). Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides (By similarity). Involved in lifespan determination in a ubiquinone-independent manner (By similarity). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis (PubMed:25961505). {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000269|PubMed:25961505}.		determination of adult lifespan [GO:0008340]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of reactive oxygen species metabolic process [GO:2000377]; ubiquinone biosynthetic process [GO:0006744]	chromosome [GO:0005694]; extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ubiquinone biosynthesis complex [GO:0110142]	3-demethoxyubiquinol 3-hydroxylase activity [GO:0008682]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]	chromosome [GO:0005694]; extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ubiquinone biosynthesis complex [GO:0110142]; 3-demethoxyubiquinol 3-hydroxylase activity [GO:0008682]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; determination of adult lifespan [GO:0008340]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of reactive oxygen species metabolic process [GO:2000377]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03194}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03194}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03194}. Mitochondrion {ECO:0000269|PubMed:25961505}. Nucleus {ECO:0000269|PubMed:25961505}. Chromosome {ECO:0000269|PubMed:25961505}.
Q99808	reviewed	S29A1_HUMAN	Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)	SLC29A1 ENT1	Homo sapiens (Human)	456	FUNCTION: Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:8986748, PubMed:10755314, PubMed:12527552, PubMed:10722669, PubMed:21795683, PubMed:35790189, PubMed:27995448, PubMed:17379602, PubMed:14759222, PubMed:15037197, PubMed:26406980). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:8986748, PubMed:10755314, PubMed:12527552, PubMed:10722669, PubMed:17379602, PubMed:14759222, PubMed:15037197, PubMed:26406980). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). {ECO:0000250|UniProtKB:O54698, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:10755314, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:14759222, ECO:0000269|PubMed:15037197, ECO:0000269|PubMed:17379602, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:26406980, ECO:0000269|PubMed:27995448, ECO:0000269|PubMed:35790189, ECO:0000269|PubMed:8986748}.	MISCELLANEOUS: The absence of the protein in tumor cells is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. {ECO:0000269|PubMed:15501974}.	adenine transport [GO:0015853]; adenosine transport [GO:0032238]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cytidine transport [GO:0015861]; excitatory postsynaptic potential [GO:0060079]; guanine transmembrane transport [GO:1903716]; hypoxanthine transport [GO:0035344]; inosine transport [GO:0035340]; lactation [GO:0007595]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; nucleobase transport [GO:0015851]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleobase transmembrane transport [GO:1904082]; pyrimidine-containing compound transmembrane transport [GO:0072531]; thymine transport [GO:0035364]; transport across blood-brain barrier [GO:0150104]; uracil transmembrane transport [GO:1903791]; uridine transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]	adenine transmembrane transporter activity [GO:0015207]; cytidine transmembrane transporter activity [GO:0015212]; guanine transmembrane transporter activity [GO:0015208]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleoside transmembrane transporter activity [GO:0005337]; purine nucleoside transmembrane transporter activity [GO:0015211]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uracil transmembrane transporter activity [GO:0015210]; uridine transmembrane transporter activity [GO:0015213]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; adenine transmembrane transporter activity [GO:0015207]; cytidine transmembrane transporter activity [GO:0015212]; guanine transmembrane transporter activity [GO:0015208]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleoside transmembrane transporter activity [GO:0005337]; purine nucleoside transmembrane transporter activity [GO:0015211]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uracil transmembrane transporter activity [GO:0015210]; uridine transmembrane transporter activity [GO:0015213]; adenine transport [GO:0015853]; adenosine transport [GO:0032238]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cytidine transport [GO:0015861]; excitatory postsynaptic potential [GO:0060079]; guanine transmembrane transport [GO:1903716]; hypoxanthine transport [GO:0035344]; inosine transport [GO:0035340]; lactation [GO:0007595]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; nucleobase transport [GO:0015851]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleobase transmembrane transport [GO:1904082]; pyrimidine-containing compound transmembrane transport [GO:0072531]; thymine transport [GO:0035364]; transport across blood-brain barrier [GO:0150104]; uracil transmembrane transport [GO:1903791]; uridine transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:23639800}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:12527552}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:11584005, ECO:0000269|PubMed:15501974, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:26406980}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basolateral membrane of Sertoli cells (PubMed:23639800). Localized to the cell membrane of erythrocytes (PubMed:23219802, PubMed:11584005). {ECO:0000269|PubMed:11584005, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:23639800}.
Q99814	reviewed	EPAS1_HUMAN	Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)	EPAS1 BHLHE73 HIF2A MOP2 PASD2	Homo sapiens (Human)	870	FUNCTION: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97481}.		angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; cellular response to hypoxia [GO:0071456]; embryonic placenta development [GO:0001892]; epithelial cell maturation [GO:0002070]; erythrocyte differentiation [GO:0030218]; lung development [GO:0030324]; mitochondrion organization [GO:0007005]; mRNA transcription by RNA polymerase II [GO:0042789]; multicellular organismal-level iron ion homeostasis [GO:0060586]; myoblast fate commitment [GO:0048625]; norepinephrine metabolic process [GO:0042415]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart rate [GO:0002027]; regulation of protein neddylation [GO:2000434]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; surfactant homeostasis [GO:0043129]; visual perception [GO:0007601]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator binding [GO:0001223]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator binding [GO:0001223]; angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; cellular response to hypoxia [GO:0071456]; embryonic placenta development [GO:0001892]; epithelial cell maturation [GO:0002070]; erythrocyte differentiation [GO:0030218]; lung development [GO:0030324]; mitochondrion organization [GO:0007005]; mRNA transcription by RNA polymerase II [GO:0042789]; multicellular organismal-level iron ion homeostasis [GO:0060586]; myoblast fate commitment [GO:0048625]; norepinephrine metabolic process [GO:0042415]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart rate [GO:0002027]; regulation of protein neddylation [GO:2000434]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; surfactant homeostasis [GO:0043129]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P97481, ECO:0000255|PROSITE-ProRule:PRU00981}. Nucleus speckle {ECO:0000250|UniProtKB:P97481}. Note=Colocalizes with HIF3A in the nucleus and speckles. {ECO:0000250|UniProtKB:P97481}.
Q99816	reviewed	TS101_HUMAN	Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)	TSG101	Homo sapiens (Human)	390	FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}.	MISCELLANEOUS: [Isoform 2]: Detected in normal as well as cancer tissues. {ECO:0000305}.	autophagosome maturation [GO:0097352]; cell cycle [GO:0007049]; cell division [GO:0051301]; endosome to lysosome transport [GO:0008333]; exosomal secretion [GO:1990182]; extracellular transport [GO:0006858]; keratinocyte differentiation [GO:0030216]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein modification process [GO:0036211]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; microtubule organizing center [GO:0005815]; multivesicular body [GO:0005771]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	calcium-dependent protein binding [GO:0048306]; DNA binding [GO:0003677]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; virion binding [GO:0046790]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; microtubule organizing center [GO:0005815]; multivesicular body [GO:0005771]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; calcium-dependent protein binding [GO:0048306]; DNA binding [GO:0003677]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; virion binding [GO:0046790]; autophagosome maturation [GO:0097352]; cell cycle [GO:0007049]; cell division [GO:0051301]; endosome to lysosome transport [GO:0008333]; exosomal secretion [GO:1990182]; extracellular transport [GO:0006858]; keratinocyte differentiation [GO:0030216]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein modification process [GO:0036211]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17853893}. Early endosome membrane {ECO:0000269|PubMed:23166352}; Peripheral membrane protein {ECO:0000305|PubMed:23166352}; Cytoplasmic side {ECO:0000305|PubMed:23166352}. Late endosome membrane {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17229889}; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17853893}. Midbody, Midbody ring {ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893}. Nucleus {ECO:0000269|PubMed:17229889}. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis. {ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893}.
Q99828	reviewed	CIB1_HUMAN	Calcium and integrin-binding protein 1 (CIB) (Calcium- and integrin-binding protein) (CIBP) (Calmyrin) (DNA-PKcs-interacting protein) (Kinase-interacting protein) (KIP) (SNK-interacting protein 2-28) (SIP2-28)	CIB1 CIB KIP PRKDCIP	Homo sapiens (Human)	191	FUNCTION: Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.; FUNCTION: [Isoform 2]: Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion. {ECO:0000269|PubMed:23503467}.; FUNCTION: (Microbial infection) Involved in keratinocyte-intrinsic immunity to human beta-papillomaviruses (HPVs). {ECO:0000269|PubMed:30068544}.	MISCELLANEOUS: The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form). {ECO:0000305|PubMed:14992593}.	angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell division [GO:0051301]; cellular response to growth factor stimulus [GO:0071363]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; endomitotic cell cycle [GO:0007113]; extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of neuron projection development [GO:0010977]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; platelet formation [GO:0030220]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of male germ cell proliferation [GO:2000256]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of cell division [GO:0051302]; regulation of cell population proliferation [GO:0042127]; response to ischemia [GO:0002931]; spermatid development [GO:0007286]; thrombopoietin-mediated signaling pathway [GO:0038163]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; cell periphery [GO:0071944]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]; vesicle [GO:0031982]	calcium ion binding [GO:0005509]; calcium-dependent protein kinase inhibitor activity [GO:0008427]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein-membrane adaptor activity [GO:0043495]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; cell periphery [GO:0071944]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]; vesicle [GO:0031982]; calcium ion binding [GO:0005509]; calcium-dependent protein kinase inhibitor activity [GO:0008427]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein-membrane adaptor activity [GO:0043495]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell division [GO:0051301]; cellular response to growth factor stimulus [GO:0071363]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; endomitotic cell cycle [GO:0007113]; extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of neuron projection development [GO:0010977]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; platelet formation [GO:0030220]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of male germ cell proliferation [GO:2000256]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of cell division [GO:0051302]; regulation of cell population proliferation [GO:0042127]; response to ischemia [GO:0002931]; spermatid development [GO:0007286]; thrombopoietin-mediated signaling pathway [GO:0038163]	SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Cell membrane, sarcolemma. Cell membrane. Apical cell membrane. Cell projection, ruffle membrane. Cell projection, filopodium tip. Cell projection, growth cone {ECO:0000269|PubMed:21215777}. Cell projection, lamellipodium {ECO:0000269|PubMed:21215777}. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Nucleus {ECO:0000269|PubMed:30068544}. Cell projection, neuron projection {ECO:0000269|PubMed:21215777}. Perikaryon {ECO:0000269|PubMed:21215777}. Note=Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic heart (By similarity). Colocalized with NBR1 to the perinuclear region. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Colocalized with RAC3 in the perinuclear area and at the cell periphery. Colocalized with PAK1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Redistributed to the cytoskeleton upon platelet aggregation. Translocates from the cytosol to the plasma membrane in a calcium-dependent manner. Colocalized with PLK3 at centrosomes in ductal breast carcinoma cells. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:23503467}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23503467}.
Q99829	reviewed	CPNE1_HUMAN	Copine-1 (Chromobindin 17) (Copine I)	CPNE1 CPN1	Homo sapiens (Human)	537	FUNCTION: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740). {ECO:0000269|PubMed:12522145, ECO:0000269|PubMed:14674885, ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:19539605, ECO:0000269|PubMed:23263657, ECO:0000269|PubMed:25450385, ECO:0000269|PubMed:9430674}.		cellular response to calcium ion [GO:0071277]; lipid metabolic process [GO:0006629]; negative regulation of DNA binding [GO:0043392]; negative regulation of gene expression [GO:0010629]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; neuron projection extension [GO:1990138]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteolysis [GO:0006508]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; vesicle-mediated transport [GO:0016192]	azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; phosphatidylserine binding [GO:0001786]	azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; phosphatidylserine binding [GO:0001786]; cellular response to calcium ion [GO:0071277]; lipid metabolic process [GO:0006629]; negative regulation of DNA binding [GO:0043392]; negative regulation of gene expression [GO:0010629]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; neuron projection extension [GO:1990138]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteolysis [GO:0006508]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:21087455}. Cytoplasm {ECO:0000269|PubMed:12949241, ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:25450385}. Cell membrane {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:25450385}. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385). {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:25450385}.
Q99832	reviewed	TCPH_HUMAN	T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]	CCT7 CCTH NIP7-1	Homo sapiens (Human)	543	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:25467444, ECO:0000305}.		binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]	cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]; binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P80313}.
Q99835	reviewed	SMO_HUMAN	Protein smoothened (Protein Gx)	SMO SMOH	Homo sapiens (Human)	787	FUNCTION: G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling. Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched. When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:P56726, ECO:0000269|PubMed:19592253}.		anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; astrocyte activation [GO:0048143]; atrial septum morphogenesis [GO:0060413]; cell fate specification [GO:0001708]; cellular response to cholesterol [GO:0071397]; central nervous system development [GO:0007417]; central nervous system neuron differentiation [GO:0021953]; cerebellar cortex morphogenesis [GO:0021696]; cerebral cortex development [GO:0021987]; commissural neuron axon guidance [GO:0071679]; contact inhibition [GO:0060242]; dentate gyrus development [GO:0021542]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral neural tube patterning [GO:0021904]; epithelial cell proliferation [GO:0050673]; epithelial-mesenchymal cell signaling [GO:0060684]; forebrain morphogenesis [GO:0048853]; gene expression [GO:0010467]; hair follicle morphogenesis [GO:0031069]; heart looping [GO:0001947]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mammary gland epithelial cell differentiation [GO:0060644]; mesenchymal to epithelial transition involved in metanephric renal vesicle formation [GO:0072285]; midgut development [GO:0007494]; multicellular organism growth [GO:0035264]; myoblast migration [GO:0051451]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA binding [GO:0043392]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of gene expression [GO:0010629]; negative regulation of hair follicle development [GO:0051799]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; pancreas morphogenesis [GO:0061113]; pattern specification process [GO:0007389]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of organ growth [GO:0046622]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of heart morphogenesis [GO:2000826]; regulation of somatic stem cell population maintenance [GO:1904672]; skeletal muscle fiber development [GO:0048741]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [GO:0021938]; smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021910]; somite development [GO:0061053]; thalamus development [GO:0021794]; type B pancreatic cell development [GO:0003323]; vasculogenesis [GO:0001570]; ventral midline determination [GO:0007371]	9+0 non-motile cilium [GO:0097731]; centriole [GO:0005814]; ciliary membrane [GO:0060170]; ciliary tip [GO:0097542]; cilium [GO:0005929]; dendrite [GO:0030425]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; plasma membrane [GO:0005886]	cAMP-dependent protein kinase inhibitor activity [GO:0004862]; G protein-coupled receptor activity [GO:0004930]; patched binding [GO:0005113]	9+0 non-motile cilium [GO:0097731]; centriole [GO:0005814]; ciliary membrane [GO:0060170]; ciliary tip [GO:0097542]; cilium [GO:0005929]; dendrite [GO:0030425]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; plasma membrane [GO:0005886]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; G protein-coupled receptor activity [GO:0004930]; patched binding [GO:0005113]; anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; astrocyte activation [GO:0048143]; atrial septum morphogenesis [GO:0060413]; cell fate specification [GO:0001708]; cellular response to cholesterol [GO:0071397]; central nervous system development [GO:0007417]; central nervous system neuron differentiation [GO:0021953]; cerebellar cortex morphogenesis [GO:0021696]; cerebral cortex development [GO:0021987]; commissural neuron axon guidance [GO:0071679]; contact inhibition [GO:0060242]; dentate gyrus development [GO:0021542]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral neural tube patterning [GO:0021904]; epithelial cell proliferation [GO:0050673]; epithelial-mesenchymal cell signaling [GO:0060684]; forebrain morphogenesis [GO:0048853]; gene expression [GO:0010467]; hair follicle morphogenesis [GO:0031069]; heart looping [GO:0001947]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mammary gland epithelial cell differentiation [GO:0060644]; mesenchymal to epithelial transition involved in metanephric renal vesicle formation [GO:0072285]; midgut development [GO:0007494]; multicellular organism growth [GO:0035264]; myoblast migration [GO:0051451]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA binding [GO:0043392]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of gene expression [GO:0010629]; negative regulation of hair follicle development [GO:0051799]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; pancreas morphogenesis [GO:0061113]; pattern specification process [GO:0007389]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of organ growth [GO:0046622]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of heart morphogenesis [GO:2000826]; regulation of somatic stem cell population maintenance [GO:1904672]; skeletal muscle fiber development [GO:0048741]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [GO:0021938]; smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021910]; somite development [GO:0061053]; thalamus development [GO:0021794]; type B pancreatic cell development [GO:0003323]; vasculogenesis [GO:0001570]; ventral midline determination [GO:0007371]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P56726}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium {ECO:0000269|PubMed:22072986}. Note=Cilium localization is promoted by SHH and is required for activity. {ECO:0000250|UniProtKB:P56726}.
Q99836	reviewed	MYD88_HUMAN	Myeloid differentiation primary response protein MyD88	MYD88	Homo sapiens (Human)	296	FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575, PubMed:33718825). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation (PubMed:33718825). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). {ECO:0000250|UniProtKB:P22366, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19506249, ECO:0000269|PubMed:20855887, ECO:0000269|PubMed:24316379, ECO:0000269|PubMed:33718825, ECO:0000269|PubMed:9013863}.		3'-UTR-mediated mRNA stabilization [GO:0070935]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; establishment of endothelial intestinal barrier [GO:0090557]; gene expression [GO:0010467]; immunoglobulin mediated immune response [GO:0016064]; induced systemic resistance [GO:0009682]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; JNK cascade [GO:0007254]; leukocyte activation involved in inflammatory response [GO:0002269]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; microglia differentiation [GO:0014004]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; neutrophil activation involved in immune response [GO:0002283]; neutrophil-mediated killing of bacterium [GO:0070944]; phagocytosis [GO:0006909]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000338]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of inflammatory response [GO:0050727]; regulation of neutrophil migration [GO:1902622]; response to amine [GO:0014075]; response to amino acid [GO:0043200]; response to ethanol [GO:0045471]; response to interleukin-1 [GO:0070555]; response to molecule of fungal origin [GO:0002238]; response to organic cyclic compound [GO:0014070]; response to peptidoglycan [GO:0032494]; signal transduction [GO:0007165]; skin development [GO:0043588]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 8 signaling pathway [GO:0034158]; type I interferon-mediated signaling pathway [GO:0060337]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATP-dependent histone chaperone activity [GO:0140674]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; interleukin-1 receptor binding [GO:0005149]; molecular adaptor activity [GO:0060090]; protein self-association [GO:0043621]; TIR domain binding [GO:0070976]; Toll binding [GO:0005121]; Toll-like receptor binding [GO:0035325]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP-dependent histone chaperone activity [GO:0140674]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; interleukin-1 receptor binding [GO:0005149]; molecular adaptor activity [GO:0060090]; protein self-association [GO:0043621]; TIR domain binding [GO:0070976]; Toll binding [GO:0005121]; Toll-like receptor binding [GO:0035325]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; establishment of endothelial intestinal barrier [GO:0090557]; gene expression [GO:0010467]; immunoglobulin mediated immune response [GO:0016064]; induced systemic resistance [GO:0009682]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; JNK cascade [GO:0007254]; leukocyte activation involved in inflammatory response [GO:0002269]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; microglia differentiation [GO:0014004]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; neutrophil activation involved in immune response [GO:0002283]; neutrophil-mediated killing of bacterium [GO:0070944]; phagocytosis [GO:0006909]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000338]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of inflammatory response [GO:0050727]; regulation of neutrophil migration [GO:1902622]; response to amine [GO:0014075]; response to amino acid [GO:0043200]; response to ethanol [GO:0045471]; response to interleukin-1 [GO:0070555]; response to molecule of fungal origin [GO:0002238]; response to organic cyclic compound [GO:0014070]; response to peptidoglycan [GO:0032494]; signal transduction [GO:0007165]; skin development [GO:0043588]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 8 signaling pathway [GO:0034158]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:15492225}. Nucleus {ECO:0000269|PubMed:21057262}.
Q99848	reviewed	EBP2_HUMAN	Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40)	EBNA1BP2 EBP2	Homo sapiens (Human)	306	FUNCTION: Required for the processing of the 27S pre-rRNA. {ECO:0000250}.		ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]	chromosome [GO:0005694]; nuclear periphery [GO:0034399]; nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]	RNA binding [GO:0003723]	chromosome [GO:0005694]; nuclear periphery [GO:0034399]; nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]; RNA binding [GO:0003723]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:19170763, ECO:0000269|PubMed:2879624}. Note=Associated with the nucleolus in an RNA-dependent manner.
Q99853	reviewed	FOXB1_HUMAN	Forkhead box protein B1 (Transcription factor FKH-5)	FOXB1 FKH5	Homo sapiens (Human)	325	FUNCTION: Transcription factor expressed by neural progenitor cells in specific regions of the embryonic neuroepithelium. Essential for the mammillary nuclei maintenance. Negatively regulates the proliferation of oligodendrocyte progenitors and promotes oligodendrocyte maturation. Also expressed in mammary glands, plays a role in lactation, controls development of mammary glands and the inferior colliculi of the midbrain in the central nervous system that regulates the milk-ejection reflex. {ECO:0000250|UniProtKB:Q64732}.		anatomical structure morphogenesis [GO:0009653]; axon target recognition [GO:0007412]; cell differentiation [GO:0030154]; cell migration in diencephalon [GO:0061381]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; floor plate development [GO:0033504]; hypothalamus cell migration [GO:0021855]; inferior colliculus development [GO:0061379]; lactation [GO:0007595]; mammary gland lobule development [GO:0061377]; mammillary body development [GO:0021767]; mammillothalamic axonal tract development [GO:0061374]; midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of transcription by RNA polymerase II [GO:0006357]; somitogenesis [GO:0001756]; spinal cord development [GO:0021510]; telencephalon cell migration [GO:0022029]; thalamus development [GO:0021794]; urogenital system development [GO:0001655]; visual learning [GO:0008542]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; axon target recognition [GO:0007412]; cell differentiation [GO:0030154]; cell migration in diencephalon [GO:0061381]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; floor plate development [GO:0033504]; hypothalamus cell migration [GO:0021855]; inferior colliculus development [GO:0061379]; lactation [GO:0007595]; mammary gland lobule development [GO:0061377]; mammillary body development [GO:0021767]; mammillothalamic axonal tract development [GO:0061374]; midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of transcription by RNA polymerase II [GO:0006357]; somitogenesis [GO:0001756]; spinal cord development [GO:0021510]; telencephalon cell migration [GO:0022029]; thalamus development [GO:0021794]; urogenital system development [GO:0001655]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q64732}.
Q99856	reviewed	ARI3A_HUMAN	AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1)	ARID3A DRIL1 DRIL3 DRX E2FBP1	Homo sapiens (Human)	593	FUNCTION: Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269|PubMed:11812999, ECO:0000269|PubMed:12692263}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; transcription coregulator activity [GO:0003712]	cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; transcription coregulator activity [GO:0003712]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:17400556}. Cytoplasm {ECO:0000269|PubMed:17400556}. Note=Shuttles between nucleus and cytoplasm.
Q99871	reviewed	HAUS7_HUMAN	HAUS augmin-like complex subunit 7 (26S proteasome-associated UCH37-interacting protein 1) (UCHL5-interacting protein) (X-linked protein STS1769)	HAUS7 UCHL5IP UIP1	Homo sapiens (Human)	358	FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.		cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	microtubule minus-end binding [GO:0051011]; thioesterase binding [GO:0031996]	centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; microtubule minus-end binding [GO:0051011]; thioesterase binding [GO:0031996]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}.
Q99873	reviewed	ANM1_HUMAN	Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) (Interferon receptor 1-bound protein 4)	PRMT1 HMT2 HRMT1L2 IR1B4	Homo sapiens (Human)	371	FUNCTION: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, FMR1, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4, SERBP1, RBM15, FOXO1, CHTOP and MAP3K5/ASK1 (PubMed:10749851, PubMed:16879614, PubMed:26876602, PubMed:22095282, PubMed:26575292, PubMed:18951090, PubMed:25284789, PubMed:30765518). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity (PubMed:18951090). Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates MAP3K5/ASK1 at 'Arg-78' and 'Arg-80' which promotes association of MAP3K5 with thioredoxin and negatively regulates MAP3K5 association with TRAF2, inhibiting MAP3K5 stimulation and MAP3K5-induced activation of JNK (PubMed:22095282). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Plays a role in regulating alternative splicing in the heart (By similarity). {ECO:0000250|UniProtKB:Q9JIF0, ECO:0000269|PubMed:10749851, ECO:0000269|PubMed:11387442, ECO:0000269|PubMed:11448779, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:18320585, ECO:0000269|PubMed:18657504, ECO:0000269|PubMed:18773938, ECO:0000269|PubMed:19124016, ECO:0000269|PubMed:20442406, ECO:0000269|PubMed:22095282, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:26876602, ECO:0000269|PubMed:28040436, ECO:0000269|PubMed:30765518}.		cardiac muscle tissue development [GO:0048738]; cell surface receptor signaling pathway [GO:0007166]; in utero embryonic development [GO:0001701]; negative regulation of JNK cascade [GO:0046329]; negative regulation of megakaryocyte differentiation [GO:0045653]; neuron projection development [GO:0031175]; peptidyl-arginine methylation [GO:0018216]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of translation [GO:0045727]; protein homooligomerization [GO:0051260]; protein methylation [GO:0006479]; regulation of BMP signaling pathway [GO:0030510]; regulation of megakaryocyte differentiation [GO:0045652]; RNA splicing [GO:0008380]; viral protein processing [GO:0019082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	enzyme binding [GO:0019899]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; methyltransferase activity [GO:0008168]; mitogen-activated protein kinase p38 binding [GO:0048273]; N-methyltransferase activity [GO:0008170]; protein methyltransferase activity [GO:0008276]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; RNA binding [GO:0003723]; S-adenosyl-L-methionine binding [GO:1904047]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; methyltransferase activity [GO:0008168]; mitogen-activated protein kinase p38 binding [GO:0048273]; N-methyltransferase activity [GO:0008170]; protein methyltransferase activity [GO:0008276]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; RNA binding [GO:0003723]; S-adenosyl-L-methionine binding [GO:1904047]; cardiac muscle tissue development [GO:0048738]; cell surface receptor signaling pathway [GO:0007166]; in utero embryonic development [GO:0001701]; negative regulation of JNK cascade [GO:0046329]; negative regulation of megakaryocyte differentiation [GO:0045653]; neuron projection development [GO:0031175]; peptidyl-arginine methylation [GO:0018216]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of translation [GO:0045727]; protein homooligomerization [GO:0051260]; protein methylation [GO:0006479]; regulation of BMP signaling pathway [GO:0030510]; regulation of megakaryocyte differentiation [GO:0045652]; RNA splicing [GO:0008380]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10749851, ECO:0000269|PubMed:11387442, ECO:0000269|PubMed:16879614}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9JIF0}. Cytoplasm {ECO:0000269|PubMed:26876602}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JIF0}. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). {ECO:0000250|UniProtKB:Q9JIF0}.
Q99877	reviewed	H2B1N_HUMAN	Histone H2B type 1-N (Histone H2B.d) (H2B/d)	H2BC15 H2BFD HIST1H2BN	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		nucleosome assembly [GO:0006334]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q99878	reviewed	H2A1J_HUMAN	Histone H2A type 1-J (Histone H2A/e)	H2AC14 H2AFE HIST1H2AJ	Homo sapiens (Human)	128	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.			extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q99879	reviewed	H2B1M_HUMAN	Histone H2B type 1-M (Histone H2B.e) (H2B/e)	H2BC14 H2BFE HIST1H2BM	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		nucleosome assembly [GO:0006334]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q99880	reviewed	H2B1L_HUMAN	Histone H2B type 1-L (Histone H2B.c) (H2B/c)	H2BC13 H2BFC HIST1H2BL	Homo sapiens (Human)	126	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		nucleosome assembly [GO:0006334]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q99884	reviewed	SC6A7_HUMAN	Sodium-dependent proline transporter (Solute carrier family 6 member 7)	SLC6A7 PROT	Homo sapiens (Human)	636	FUNCTION: Brain specific sodium (and chloride)-dependent proline transporter (PubMed:7651355). Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals (Probable). {ECO:0000269|PubMed:7651355, ECO:0000305|PubMed:7651355}.		neurotransmitter transport [GO:0006836]; proline transport [GO:0015824]; protein catabolic process [GO:0030163]; sodium ion transmembrane transport [GO:0035725]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	L-proline transmembrane transporter activity [GO:0015193]; proline:sodium symporter activity [GO:0005298]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; L-proline transmembrane transporter activity [GO:0015193]; proline:sodium symporter activity [GO:0005298]; neurotransmitter transport [GO:0006836]; proline transport [GO:0015824]; protein catabolic process [GO:0030163]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Synaptic cell membrane {ECO:0000269|PubMed:7651355}; Multi-pass membrane protein {ECO:0000255}.
Q99895	reviewed	CTRC_HUMAN	Chymotrypsin-C (EC 3.4.21.2) (Caldecrin)	CTRC CLCR	Homo sapiens (Human)	268	FUNCTION: Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. {ECO:0000269|PubMed:23430245}.		intracellular calcium ion homeostasis [GO:0006874]; proteolysis [GO:0006508]		peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; intracellular calcium ion homeostasis [GO:0006874]; proteolysis [GO:0006508]	
Q99909	reviewed	SSX3_HUMAN	Protein SSX3 (Cancer/testis antigen 5.3) (CT5.3)	SSX3	Homo sapiens (Human)	188	FUNCTION: Could act as a modulator of transcription.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]		nucleus [GO:0005634]; regulation of DNA-templated transcription [GO:0006355]	
Q99928	reviewed	GBRG3_HUMAN	Gamma-aminobutyric acid receptor subunit gamma-3 (GABA(A) receptor subunit gamma-3)	GABRG3	Homo sapiens (Human)	467	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.	MISCELLANEOUS: This subunit carries the benzodiazepine binding site.	chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of postsynaptic membrane potential [GO:0060078]; response to xenobiotic stimulus [GO:0009410]; synaptic transmission, GABAergic [GO:0051932]	chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; microtubule cytoskeleton [GO:0015630]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; microtubule cytoskeleton [GO:0015630]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of postsynaptic membrane potential [GO:0060078]; response to xenobiotic stimulus [GO:0009410]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Q99929	reviewed	ASCL2_HUMAN	Achaete-scute homolog 2 (ASH-2) (hASH2) (Class A basic helix-loop-helix protein 45) (bHLHa45) (Mash2)	ASCL2 BHLHA45 HASH2	Homo sapiens (Human)	193	FUNCTION: Transcription factor. Binds to E-box motifs 5'-CANNTG-3' in the regulatory elements of target genes, probably as a heterodimer with another basic helix-loop-helix (bHLH) protein such as the transcription factor TCF3. May bind both open and closed chromatin, acting as a pioneer transcription factor to allow other factors to bind and activate lineage-specific genes. Required during post-implantation development for the generation of some differentiated trophoblast cell types. Transcriptional activity of ASCL2 may be antagonised in a subset of trophoblast cells by bHLH transcription factor HAND1, perhaps by competing for dimerization with other bHLH proteins. Involved in differentiation and function of follicular T-helper (Tfh) cells, thereby playing a role in germinal center responses; probably modulates expression of genes involved in Tfh cell function, such as BCL6. May also act as a suppressor of Th1-, Th2- and Th17-cell differentiation. Induces the formation of stem cells in intestinal crypts in vitro, synergistically activating transcription of target genes, such as SOX9, together with TCF4/beta-catenin. May form a bistable transcriptional switch, controlling expression of its own gene together with Wnt/R-spondin signaling, and thereby maintaining stem cell characteristics (By similarity). Modulates expression of target genes, including perhaps down-regulating EGR1/Krox24 and chemokine CXCL10/Mob-1 and up-regulating CXCR4 and CDKN1C/p57kip2, in Schwann cells. May play a role in reducing proliferation of Schwann cells, perhaps acting via modulation of expression of CDKN1C (By similarity). May be dispensable for blastocyst formation and later embryonic function (By similarity). May be involved in the determination of neuronal precursors (By similarity). {ECO:0000250|UniProtKB:O35885, ECO:0000250|UniProtKB:P19360}.	MISCELLANEOUS: In contrast to the mouse ortholog, the ASCL2 locus is not imprinted in human placenta. {ECO:0000269|PubMed:12099555}.	chorionic trophoblast cell development [GO:0060719]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; placenta development [GO:0001890]; positive regulation of T cell migration [GO:2000406]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; response to hypoxia [GO:0001666]; sensory organ development [GO:0007423]; somatic stem cell population maintenance [GO:0035019]; spongiotrophoblast differentiation [GO:0060708]; spongiotrophoblast layer development [GO:0060712]; T follicular helper cell differentiation [GO:0061470]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; chorionic trophoblast cell development [GO:0060719]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; placenta development [GO:0001890]; positive regulation of T cell migration [GO:2000406]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; response to hypoxia [GO:0001666]; sensory organ development [GO:0007423]; somatic stem cell population maintenance [GO:0035019]; spongiotrophoblast differentiation [GO:0060708]; spongiotrophoblast layer development [GO:0060712]; T follicular helper cell differentiation [GO:0061470]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11440538}.
Q99932	reviewed	SPAG8_HUMAN	Sperm-associated antigen 8 (HSD-1) (Sperm membrane protein 1) (SMP-1) (Sperm membrane protein BS-84)	SPAG8	Homo sapiens (Human)	485	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (PubMed:19548270). May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252). {ECO:0000250|UniProtKB:Q3V0Q6, ECO:0000269|PubMed:10500252, ECO:0000269|PubMed:19548270, ECO:0000269|PubMed:36191189}.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell cycle [GO:0007049]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]; axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819]	microtubule binding [GO:0008017]	acrosomal vesicle [GO:0001669]; axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819]; microtubule binding [GO:0008017]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3V0Q6}. Nucleus {ECO:0000250|UniProtKB:Q3V0Q6}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:15014887, ECO:0000269|PubMed:17187156, ECO:0000269|PubMed:8788182}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:19548270}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19548270}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Note=In mature sperm cells, detected in the acrosomal region of the head and in the middle piece of the tail (By similarity). Localized to the nucleus and cytoplasm of spermatocytes and round spermatids while, in elongating spermatids, expressed in the cytoplasm but not in the nucleus (By similarity). During the cell cycle, localized on the microtubule-organizing center (MTOC) during prophase. In metaphase, extends along spindle microtubules. In anaphase, detected on the astral microtubules and mid-zone. In telophase, remains at the mid-zone. After cytokinesis, returns to the MTOC (PubMed:19548270). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (By similarity). {ECO:0000250|UniProtKB:E1BNS6, ECO:0000250|UniProtKB:Q3V0Q6, ECO:0000269|PubMed:19548270}.
Q99933	reviewed	BAG1_HUMAN	BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1)	BAG1 HAP	Homo sapiens (Human)	345	FUNCTION: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). {ECO:0000269|PubMed:12724406, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:9305631, ECO:0000269|PubMed:9873016}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation at Met-72 of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative initiation at Met-116 of isoform 1. {ECO:0000305}.	apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; chaperone cofactor-dependent protein refolding [GO:0051085]; negative regulation of apoptotic process [GO:0043066]; protein stabilization [GO:0050821]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	adenyl-nucleotide exchange factor activity [GO:0000774]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; adenyl-nucleotide exchange factor activity [GO:0000774]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; chaperone cofactor-dependent protein refolding [GO:0051085]; negative regulation of apoptotic process [GO:0043066]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.
Q99935	reviewed	PROL1_HUMAN	Opiorphin prepropeptide (Basic proline-rich lacrimal protein) (Proline-rich protein 1) (PRL1) [Cleaved into: Opiorphin]	OPRPN BPLP PROL1	Homo sapiens (Human)	248	FUNCTION: Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection. {ECO:0000269|PubMed:17101991}.		regulation of sensory perception of pain [GO:0051930]; retina homeostasis [GO:0001895]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	endopeptidase inhibitor activity [GO:0004866]; peptidase inhibitor activity [GO:0030414]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; endopeptidase inhibitor activity [GO:0004866]; peptidase inhibitor activity [GO:0030414]; regulation of sensory perception of pain [GO:0051930]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17101991}.
Q99941	reviewed	ATF6B_HUMAN	Cyclic AMP-dependent transcription factor ATF-6 beta (cAMP-dependent transcription factor ATF-6 beta) (Activating transcription factor 6 beta) (ATF6-beta) (Protein G13) (cAMP response element-binding protein-related protein) (Creb-rp) (cAMP-responsive element-binding protein-like 1) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 beta]	ATF6B CREBL1 G13	Homo sapiens (Human)	703	FUNCTION: [Cyclic AMP-dependent transcription factor ATF-6 beta]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944). {ECO:0000269|PubMed:11256944}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress (PubMed:11256944). Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE (PubMed:11256944). {ECO:0000269|PubMed:11256944}.		ATF6-mediated unfolded protein response [GO:0036500]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of ATF6-mediated unfolded protein response [GO:1903892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ATF6-mediated unfolded protein response [GO:0036500]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of ATF6-mediated unfolded protein response [GO:1903892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11256944}; Single-pass type II membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus {ECO:0000269|PubMed:11256944}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. {ECO:0000269|PubMed:11256944}.
Q99942	reviewed	RNF5_HUMAN	E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)	RNF5 G16 NG2 RMA1	Homo sapiens (Human)	180	FUNCTION: Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:11329381, PubMed:12861019, PubMed:16176924, PubMed:19285439, PubMed:19269966). May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (PubMed:11329381). Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (PubMed:12861019). Catalyzes ubiquitination of Salmonella type III secreted protein sopA (PubMed:16176924). Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (PubMed:19269966). Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (PubMed:19285439). Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945). {ECO:0000269|PubMed:11329381, ECO:0000269|PubMed:12861019, ECO:0000269|PubMed:16176924, ECO:0000269|PubMed:19269966, ECO:0000269|PubMed:19285439, ECO:0000269|PubMed:23093945}.		ER-associated misfolded protein catabolic process [GO:0071712]; ERAD pathway [GO:0036503]; negative regulation of autophagy [GO:0010507]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of autophagosome assembly [GO:2000785]; response to bacterium [GO:0009617]; transmembrane transport [GO:0055085]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; ER-associated misfolded protein catabolic process [GO:0071712]; ERAD pathway [GO:0036503]; negative regulation of autophagy [GO:0010507]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of autophagosome assembly [GO:2000785]; response to bacterium [GO:0009617]; transmembrane transport [GO:0055085]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9533025}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:19285439}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19285439}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles. {ECO:0000269|PubMed:9533025}.
Q99943	reviewed	PLCA_HUMAN	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 1) (1-AGP acyltransferase 1) (1-AGPAT 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha) (Protein G15)	AGPAT1 G15	Homo sapiens (Human)	283	FUNCTION: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269|PubMed:21873652, ECO:0000269|PubMed:9461603}.		CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21873652, ECO:0000269|PubMed:9461603}; Multi-pass membrane protein {ECO:0000255}.
Q99944	reviewed	EGFL8_HUMAN	Epidermal growth factor-like protein 8 (EGF-like protein 8) (Vascular endothelial statin-2) (VE-statin-2)	EGFL8 C6orf8 NG3 UNQ8752/PRO29920	Homo sapiens (Human)	293			anatomical structure development [GO:0048856]	cell surface [GO:0009986]; extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; signaling receptor binding [GO:0005102]; anatomical structure development [GO:0048856]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q99946	reviewed	PRRT1_HUMAN	Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) (Synapse differentiation-induced protein 4) (SynDIG4)	PRRT1 C6orf31 NG5	Homo sapiens (Human)	306	FUNCTION: Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression. {ECO:0000250|UniProtKB:O35449}.		learning or memory [GO:0007611]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; protein localization to cell surface [GO:0034394]; protein phosphorylation [GO:0006468]; regulation of AMPA receptor activity [GO:2000311]; synapse organization [GO:0050808]	membrane [GO:0016020]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672]	identical protein binding [GO:0042802]; signaling receptor regulator activity [GO:0030545]	membrane [GO:0016020]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672]; identical protein binding [GO:0042802]; signaling receptor regulator activity [GO:0030545]; learning or memory [GO:0007611]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; protein localization to cell surface [GO:0034394]; protein phosphorylation [GO:0006468]; regulation of AMPA receptor activity [GO:2000311]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6MG82}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6MG82}. Synapse {ECO:0000250|UniProtKB:Q6MG82}.
Q99952	reviewed	PTN18_HUMAN	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase)	PTPN18 BDP1	Homo sapiens (Human)	460	FUNCTION: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.		blastocyst formation [GO:0001825]; negative regulation of ERBB signaling pathway [GO:1901185]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; blastocyst formation [GO:0001825]; negative regulation of ERBB signaling pathway [GO:1901185]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q99956	reviewed	DUS9_HUMAN	Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4)	DUSP9 MKP4	Homo sapiens (Human)	384	FUNCTION: Inactivates MAP kinases. Has a specificity for the ERK family.		ERK1 and ERK2 cascade [GO:0070371]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]; ERK1 and ERK2 cascade [GO:0070371]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cytoplasm.
Q99958	reviewed	FOXC2_HUMAN	Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14)	FOXC2 FKHL14 MFH1	Homo sapiens (Human)	501	FUNCTION: Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. {ECO:0000269|PubMed:9169153}.		anatomical structure morphogenesis [GO:0009653]; apoptotic process involved in outflow tract morphogenesis [GO:0003275]; artery morphogenesis [GO:0048844]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye development [GO:0043010]; cardiac muscle cell proliferation [GO:0060038]; cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; embryonic heart tube development [GO:0035050]; embryonic viscerocranium morphogenesis [GO:0048703]; glomerular endothelium development [GO:0072011]; glomerular mesangial cell development [GO:0072144]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; lymphangiogenesis [GO:0001946]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of apoptotic process involved in outflow tract morphogenesis [GO:1902257]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; Notch signaling pathway [GO:0007219]; ossification [GO:0001503]; paraxial mesodermal cell fate commitment [GO:0048343]; podocyte differentiation [GO:0072112]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular wound healing [GO:0035470]; regulation of organ growth [GO:0046620]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hormone [GO:0009725]; somitogenesis [GO:0001756]; ureteric bud development [GO:0001657]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; apoptotic process involved in outflow tract morphogenesis [GO:0003275]; artery morphogenesis [GO:0048844]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye development [GO:0043010]; cardiac muscle cell proliferation [GO:0060038]; cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; embryonic heart tube development [GO:0035050]; embryonic viscerocranium morphogenesis [GO:0048703]; glomerular endothelium development [GO:0072011]; glomerular mesangial cell development [GO:0072144]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; lymphangiogenesis [GO:0001946]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of apoptotic process involved in outflow tract morphogenesis [GO:1902257]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; Notch signaling pathway [GO:0007219]; ossification [GO:0001503]; paraxial mesodermal cell fate commitment [GO:0048343]; podocyte differentiation [GO:0072112]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular wound healing [GO:0035470]; regulation of organ growth [GO:0046620]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hormone [GO:0009725]; somitogenesis [GO:0001756]; ureteric bud development [GO:0001657]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:23878394}.
Q99959	reviewed	PKP2_HUMAN	Plakophilin-2	PKP2	Homo sapiens (Human)	881	FUNCTION: Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes (By similarity). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). May play a role in junctional plaques (PubMed:22781308). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962}.	MISCELLANEOUS: [Isoform 2]: Undetected in heart.; MISCELLANEOUS: [Isoform 1]: Major isoform in heart. {ECO:0000305}.	bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-cell signaling involved in cardiac conduction [GO:0086019]; desmosome assembly [GO:0002159]; desmosome organization [GO:0002934]; heart development [GO:0007507]; intermediate filament bundle assembly [GO:0045110]; maintenance of animal organ identity [GO:0048496]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of cell-substrate adhesion [GO:0010810]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; ventricular cardiac muscle cell action potential [GO:0086005]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; intermediate filament binding [GO:0019215]; molecular adaptor activity [GO:0060090]; protein kinase C binding [GO:0005080]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; intermediate filament binding [GO:0019215]; molecular adaptor activity [GO:0060090]; protein kinase C binding [GO:0005080]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-cell signaling involved in cardiac conduction [GO:0086019]; desmosome assembly [GO:0002159]; desmosome organization [GO:0002934]; heart development [GO:0007507]; intermediate filament bundle assembly [GO:0045110]; maintenance of animal organ identity [GO:0048496]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of cell-substrate adhesion [GO:0010810]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; ventricular cardiac muscle cell action potential [GO:0086005]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11416169, ECO:0000269|PubMed:11790773, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962}. Cell junction, desmosome {ECO:0000269|PubMed:19533476, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:34368962}. Cell junction {ECO:0000269|PubMed:28169297}. Cytoplasm {ECO:0000269|PubMed:34368962}. Note=Colocalizes with CTNNA3 and SCN5A/Nav1.5 at intercalated disks in the heart. {ECO:0000250|UniProtKB:Q9CQ73}.
Q99961	reviewed	SH3G1_HUMAN	Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)	SH3GL1 CNSA1 SH3D2B	Homo sapiens (Human)	368	FUNCTION: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.		central nervous system development [GO:0007417]; signal transduction [GO:0007165]; synaptic vesicle uncoating [GO:0016191]	anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; glutamatergic synapse [GO:0098978]; podosome [GO:0002102]; presynapse [GO:0098793]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]	anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; glutamatergic synapse [GO:0098978]; podosome [GO:0002102]; presynapse [GO:0098793]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; central nervous system development [GO:0007417]; signal transduction [GO:0007165]; synaptic vesicle uncoating [GO:0016191]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, podosome {ECO:0000269|PubMed:23285027}. Note=Associated with postsynaptic endosomes in hippocampal neurons. {ECO:0000250}.
Q99962	reviewed	SH3G2_HUMAN	Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)	SH3GL2 CNSA2 SH3D2A	Homo sapiens (Human)	352	FUNCTION: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:Q62420}.	MISCELLANEOUS: HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR domain binds liposomes and induces formation of tubules from liposomes. The N-terminal amphipathic helix is required for liposome binding. The second amphipathic helix enhances liposome tubulation.	cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; central nervous system development [GO:0007417]; dendrite extension [GO:0097484]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; neuron projection development [GO:0031175]; signal transduction [GO:0007165]; synaptic vesicle uncoating [GO:0016191]	cell projection [GO:0042995]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	identical protein binding [GO:0042802]; lipid binding [GO:0008289]	cell projection [GO:0042995]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; central nervous system development [GO:0007417]; dendrite extension [GO:0097484]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; neuron projection development [GO:0031175]; signal transduction [GO:0007165]; synaptic vesicle uncoating [GO:0016191]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O35179}. Membrane {ECO:0000250|UniProtKB:O35179}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35179}. Early endosome {ECO:0000250|UniProtKB:Q62420}. Presynapse {ECO:0000250|UniProtKB:O35179}.
Q99963	reviewed	SH3G3_HUMAN	Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)	SH3GL3 CNSA3 SH3D2C	Homo sapiens (Human)	347	FUNCTION: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.		central nervous system development [GO:0007417]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; positive regulation of neuron differentiation [GO:0045666]; signal transduction [GO:0007165]; synaptic vesicle uncoating [GO:0016191]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; glutamatergic synapse [GO:0098978]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic endosome [GO:0098845]; presynapse [GO:0098793]	identical protein binding [GO:0042802]; lipid binding [GO:0008289]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; glutamatergic synapse [GO:0098978]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic endosome [GO:0098845]; presynapse [GO:0098793]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; central nervous system development [GO:0007417]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; positive regulation of neuron differentiation [GO:0045666]; signal transduction [GO:0007165]; synaptic vesicle uncoating [GO:0016191]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O35180}. Early endosome membrane {ECO:0000250|UniProtKB:O35180}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35180}. Note=Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons. {ECO:0000250|UniProtKB:O35180}.
Q99965	reviewed	ADAM2_HUMAN	Disintegrin and metalloproteinase domain-containing protein 2 (ADAM 2) (Cancer/testis antigen 15) (CT15) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta)	ADAM2 FTNB	Homo sapiens (Human)	735	FUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.	MISCELLANEOUS: In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene.	adult behavior [GO:0030534]; binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; male gonad development [GO:0008584]; positive regulation of gene expression [GO:0010628]; proteolysis [GO:0006508]; visual learning [GO:0008542]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; adult behavior [GO:0030534]; binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; male gonad development [GO:0008584]; positive regulation of gene expression [GO:0010628]; proteolysis [GO:0006508]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q99966	reviewed	CITE1_HUMAN	Cbp/p300-interacting transactivator 1 (Melanocyte-specific protein 1)	CITED1 MSG1	Homo sapiens (Human)	193	FUNCTION: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:21172805}.		apoptotic process [GO:0006915]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; labyrinthine layer development [GO:0060711]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; mesenchymal to epithelial transition [GO:0060231]; metanephros development [GO:0001656]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of Wnt signaling pathway [GO:0030178]; nucleocytoplasmic transport [GO:0006913]; pigmentation [GO:0043473]; placenta development [GO:0001890]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to cytokine [GO:0034097]; response to estrogen [GO:0043627]; response to insulin [GO:0032868]; response to interleukin-1 [GO:0070555]; response to interleukin-11 [GO:0071105]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to interleukin-6 [GO:0070741]; response to interleukin-9 [GO:0071104]; response to lipopolysaccharide [GO:0032496]; response to parathyroid hormone [GO:0071107]; response to transforming growth factor beta [GO:0071559]; response to type II interferon [GO:0034341]; SMAD protein signal transduction [GO:0060395]; spongiotrophoblast layer development [GO:0060712]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; co-SMAD binding [GO:0070410]; LBD domain binding [GO:0050693]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; co-SMAD binding [GO:0070410]; LBD domain binding [GO:0050693]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; apoptotic process [GO:0006915]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; labyrinthine layer development [GO:0060711]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; mesenchymal to epithelial transition [GO:0060231]; metanephros development [GO:0001656]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of Wnt signaling pathway [GO:0030178]; nucleocytoplasmic transport [GO:0006913]; pigmentation [GO:0043473]; placenta development [GO:0001890]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to cytokine [GO:0034097]; response to estrogen [GO:0043627]; response to insulin [GO:0032868]; response to interleukin-1 [GO:0070555]; response to interleukin-11 [GO:0071105]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to interleukin-6 [GO:0070741]; response to interleukin-9 [GO:0071104]; response to lipopolysaccharide [GO:0032496]; response to parathyroid hormone [GO:0071107]; response to transforming growth factor beta [GO:0071559]; response to type II interferon [GO:0034341]; SMAD protein signal transduction [GO:0060395]; spongiotrophoblast layer development [GO:0060712]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16864582}. Cytoplasm {ECO:0000269|PubMed:16864582}. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner.
Q99967	reviewed	CITE2_HUMAN	Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj)	CITED2 MRG1	Homo sapiens (Human)	270	FUNCTION: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:15051727}.		adrenal cortex formation [GO:0035802]; bone morphogenesis [GO:0060349]; cardiac neural crest cell development involved in heart development [GO:0061308]; cell population proliferation [GO:0008283]; cellular senescence [GO:0090398]; central nervous system development [GO:0007417]; cranial nerve morphogenesis [GO:0021602]; decidualization [GO:0046697]; determination of left/right symmetry [GO:0007368]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic heart tube left/right pattern formation [GO:0060971]; embryonic placenta development [GO:0001892]; embryonic process involved in female pregnancy [GO:0060136]; endocardial cushion development [GO:0003197]; erythrocyte development [GO:0048821]; granulocyte differentiation [GO:0030851]; heart development [GO:0007507]; heart looping [GO:0001947]; hematopoietic progenitor cell differentiation [GO:0002244]; left/right axis specification [GO:0070986]; left/right pattern formation [GO:0060972]; lens morphogenesis in camera-type eye [GO:0002089]; liver development [GO:0001889]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; neural tube closure [GO:0001843]; nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900164]; outflow tract morphogenesis [GO:0003151]; peripheral nervous system development [GO:0007422]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of male gonad development [GO:2000020]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; pulmonary artery morphogenesis [GO:0061156]; regulation of animal organ formation [GO:0003156]; response to estrogen [GO:0043627]; response to fluid shear stress [GO:0034405]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; sex determination [GO:0007530]; skeletal muscle cell differentiation [GO:0035914]; spleen development [GO:0048536]; thymus development [GO:0048538]; transforming growth factor beta receptor signaling pathway [GO:0007179]; trophectodermal cell differentiation [GO:0001829]; vasculogenesis [GO:0001570]; ventricular septum morphogenesis [GO:0060412]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; histone acetyltransferase binding [GO:0035035]; LBD domain binding [GO:0050693]; molecular function activator activity [GO:0140677]; protein domain specific binding [GO:0019904]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; histone acetyltransferase binding [GO:0035035]; LBD domain binding [GO:0050693]; molecular function activator activity [GO:0140677]; protein domain specific binding [GO:0019904]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; adrenal cortex formation [GO:0035802]; bone morphogenesis [GO:0060349]; cardiac neural crest cell development involved in heart development [GO:0061308]; cell population proliferation [GO:0008283]; cellular senescence [GO:0090398]; central nervous system development [GO:0007417]; cranial nerve morphogenesis [GO:0021602]; decidualization [GO:0046697]; determination of left/right symmetry [GO:0007368]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic heart tube left/right pattern formation [GO:0060971]; embryonic placenta development [GO:0001892]; embryonic process involved in female pregnancy [GO:0060136]; endocardial cushion development [GO:0003197]; erythrocyte development [GO:0048821]; granulocyte differentiation [GO:0030851]; heart development [GO:0007507]; heart looping [GO:0001947]; hematopoietic progenitor cell differentiation [GO:0002244]; left/right axis specification [GO:0070986]; left/right pattern formation [GO:0060972]; lens morphogenesis in camera-type eye [GO:0002089]; liver development [GO:0001889]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; neural tube closure [GO:0001843]; nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900164]; outflow tract morphogenesis [GO:0003151]; peripheral nervous system development [GO:0007422]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of male gonad development [GO:2000020]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; pulmonary artery morphogenesis [GO:0061156]; regulation of animal organ formation [GO:0003156]; response to estrogen [GO:0043627]; response to fluid shear stress [GO:0034405]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; sex determination [GO:0007530]; skeletal muscle cell differentiation [GO:0035914]; spleen development [GO:0048536]; thymus development [GO:0048538]; transforming growth factor beta receptor signaling pathway [GO:0007179]; trophectodermal cell differentiation [GO:0001829]; vasculogenesis [GO:0001570]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:8901575, ECO:0000269|PubMed:9887100}. Note=Colocalizes with EP300 in dot-like structures.
Q99969	reviewed	RARR2_HUMAN	Retinoic acid receptor responder protein 2 (Chemerin) (RAR-responsive protein TIG2) (Tazarotene-induced gene 2 protein)	RARRES2 TIG2	Homo sapiens (Human)	163	FUNCTION: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Acts also as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2 (PubMed:27716822). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin. {ECO:0000269|PubMed:14675762, ECO:0000269|PubMed:17635925, ECO:0000269|PubMed:17767914, ECO:0000269|PubMed:18242188, ECO:0000269|PubMed:20237162, ECO:0000269|PubMed:22634313, ECO:0000269|PubMed:23527010, ECO:0000269|PubMed:27716822}.		antifungal humoral response [GO:0019732]; antifungal innate immune response [GO:0061760]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; embryonic digestive tract development [GO:0048566]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; positive regulation of chemotaxis [GO:0050921]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of protein phosphorylation [GO:0001934]; regulation of lipid catabolic process [GO:0050994]; retinoid metabolic process [GO:0001523]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089]	signaling receptor binding [GO:0005102]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089]; signaling receptor binding [GO:0005102]; antifungal humoral response [GO:0019732]; antifungal innate immune response [GO:0061760]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; embryonic digestive tract development [GO:0048566]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; positive regulation of chemotaxis [GO:0050921]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of protein phosphorylation [GO:0001934]; regulation of lipid catabolic process [GO:0050994]; retinoid metabolic process [GO:0001523]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9DD06}.
Q99972	reviewed	MYOC_HUMAN	Myocilin (Myocilin 55 kDa subunit) (Trabecular meshwork-induced glucocorticoid response protein) [Cleaved into: Myocilin, N-terminal fragment (Myocilin 20 kDa N-terminal fragment); Myocilin, C-terminal fragment (Myocilin 35 kDa N-terminal fragment)]	MYOC GLC1A TIGR	Homo sapiens (Human)	504	FUNCTION: Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork. {ECO:0000250|UniProtKB:O70624, ECO:0000269|PubMed:17516541, ECO:0000269|PubMed:17984096, ECO:0000269|PubMed:18855004, ECO:0000269|PubMed:19188438, ECO:0000269|PubMed:19959812, ECO:0000269|PubMed:21656515, ECO:0000269|PubMed:23629661, ECO:0000269|PubMed:23897819}.		bone development [GO:0060348]; clustering of voltage-gated sodium channels [GO:0045162]; ERBB2-ERBB3 signaling pathway [GO:0038133]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; neuron projection development [GO:0031175]; non-canonical Wnt signaling pathway via JNK cascade [GO:0038031]; osteoblast differentiation [GO:0001649]; positive regulation of cell migration [GO:0030335]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]; skeletal muscle hypertrophy [GO:0014734]	cilium [GO:0005929]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; node of Ranvier [GO:0033268]; rough endoplasmic reticulum [GO:0005791]	fibronectin binding [GO:0001968]; frizzled binding [GO:0005109]; metal ion binding [GO:0046872]; myosin light chain binding [GO:0032027]; receptor tyrosine kinase binding [GO:0030971]	cilium [GO:0005929]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; node of Ranvier [GO:0033268]; rough endoplasmic reticulum [GO:0005791]; fibronectin binding [GO:0001968]; frizzled binding [GO:0005109]; metal ion binding [GO:0046872]; myosin light chain binding [GO:0032027]; receptor tyrosine kinase binding [GO:0030971]; bone development [GO:0060348]; clustering of voltage-gated sodium channels [GO:0045162]; ERBB2-ERBB3 signaling pathway [GO:0038133]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; neuron projection development [GO:0031175]; non-canonical Wnt signaling pathway via JNK cascade [GO:0038031]; osteoblast differentiation [GO:0001649]; positive regulation of cell migration [GO:0030335]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]; skeletal muscle hypertrophy [GO:0014734]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11431441, ECO:0000269|PubMed:12697062, ECO:0000269|PubMed:19287508, ECO:0000269|PubMed:9497363}. Golgi apparatus {ECO:0000269|PubMed:11053284}. Cytoplasmic vesicle {ECO:0000269|PubMed:11431441}. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11773026, ECO:0000305|PubMed:11431441}. Secreted, extracellular exosome {ECO:0000269|PubMed:15944158}. Mitochondrion {ECO:0000269|PubMed:17516541}. Mitochondrion intermembrane space {ECO:0000269|PubMed:17516541}. Mitochondrion inner membrane {ECO:0000269|PubMed:17516541}. Mitochondrion outer membrane {ECO:0000269|PubMed:17516541}. Rough endoplasmic reticulum {ECO:0000269|PubMed:19287508}. Cell projection. Cell projection, cilium {ECO:0000269|PubMed:9169133}. Note=Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum (PubMed:9169133). It is only imported to mitochondria in the trabecular meshwork (PubMed:17516541). Localizes to the Golgi apparatus in Schlemm's canal endothelial cells (PubMed:11053284). Appears in the extracellular space of trabecular meshwork cells by an unconventional mechanism, likely associated with exosome-like vesicles (PubMed:15944158). Localizes in trabecular meshwork extracellular matrix (PubMed:15944158). {ECO:0000269|PubMed:11053284, ECO:0000269|PubMed:15944158, ECO:0000269|PubMed:17516541, ECO:0000269|PubMed:9169133}.; SUBCELLULAR LOCATION: [Myocilin, C-terminal fragment]: Secreted.; SUBCELLULAR LOCATION: [Myocilin, N-terminal fragment]: Endoplasmic reticulum. Note=Remains retained in the endoplasmic reticulum.
Q99973	reviewed	TEP1_HUMAN	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog)	TEP1 TLP1 TP1	Homo sapiens (Human)	2627	FUNCTION: Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Also a component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). {ECO:0000250|UniProtKB:P97499, ECO:0000269|PubMed:19179534}.	MISCELLANEOUS: [Isoform 2]: May be due to an exon inclusion. {ECO:0000305}.	telomere maintenance via recombination [GO:0000722]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; ribonucleoprotein complex [GO:1990904]; telomerase holoenzyme complex [GO:0005697]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; ribonucleoprotein complex [GO:1990904]; telomerase holoenzyme complex [GO:0005697]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034]; telomere maintenance via recombination [GO:0000722]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere.
Q99983	reviewed	OMD_HUMAN	Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD)	OMD SLRR2C UNQ190/PRO216	Homo sapiens (Human)	421	FUNCTION: May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin. {ECO:0000250|UniProtKB:O77742}.		cell adhesion [GO:0007155]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]		extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q99985	reviewed	SEM3C_HUMAN	Semaphorin-3C (Semaphorin-E) (Sema E)	SEMA3C SEMAE	Homo sapiens (Human)	751	FUNCTION: Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; blood vessel remodeling [GO:0001974]; cardiac endothelial to mesenchymal transition [GO:0140074]; cardiac right ventricle morphogenesis [GO:0003215]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; immune response [GO:0006955]; limb bud formation [GO:0060174]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; neural tube development [GO:0021915]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of cell migration [GO:0030335]; post-embryonic development [GO:0009791]; pulmonary myocardium development [GO:0003350]; response to xenobiotic stimulus [GO:0009410]; semaphorin-plexin signaling pathway [GO:0071526]; somitogenesis [GO:0001756]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; axon guidance [GO:0007411]; blood vessel remodeling [GO:0001974]; cardiac endothelial to mesenchymal transition [GO:0140074]; cardiac right ventricle morphogenesis [GO:0003215]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; immune response [GO:0006955]; limb bud formation [GO:0060174]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; neural tube development [GO:0021915]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of cell migration [GO:0030335]; post-embryonic development [GO:0009791]; pulmonary myocardium development [GO:0003350]; response to xenobiotic stimulus [GO:0009410]; semaphorin-plexin signaling pathway [GO:0071526]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Secreted.
Q99986	reviewed	VRK1_HUMAN	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1)	VRK1	Homo sapiens (Human)	396	FUNCTION: Serine/threonine kinase involved in cell cycle, nuclear condensation and transcription regulation (PubMed:14645249, PubMed:18617507, PubMed:19103756). Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation (PubMed:19103756). Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2 (PubMed:10951572). Phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity (PubMed:33076429). Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm (PubMed:16495336). Phosphorylates ATF2 which activates its transcriptional activity (PubMed:15105425). {ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:33076429}.		cell division [GO:0051301]; DNA damage response [GO:0006974]; Golgi disassembly [GO:0090166]; mitotic nuclear membrane disassembly [GO:0007077]; positive regulation of protein localization to chromatin [GO:0120187]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	cytosol [GO:0005829]; Golgi stack [GO:0005795]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; histone binding [GO:0042393]; histone H3S10 kinase activity [GO:0035175]; histone H3T3 kinase activity [GO:0072354]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; Golgi stack [GO:0005795]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; histone binding [GO:0042393]; histone H3S10 kinase activity [GO:0035175]; histone H3T3 kinase activity [GO:0072354]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell division [GO:0051301]; DNA damage response [GO:0006974]; Golgi disassembly [GO:0090166]; mitotic nuclear membrane disassembly [GO:0007077]; positive regulation of protein localization to chromatin [GO:0120187]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:18617507}. Cytoplasm {ECO:0000269|PubMed:18617507}. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.
Q99988	reviewed	GDF15_HUMAN	Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)	GDF15 MIC1 PDF PLAB PTGFB	Homo sapiens (Human)	308	FUNCTION: Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity). {ECO:0000250|UniProtKB:Q9Z0J7, ECO:0000269|PubMed:23468844, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:29046435}.		cell-cell signaling [GO:0007267]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; reduction of food intake in response to dietary excess [GO:0002023]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; cell-cell signaling [GO:0007267]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; reduction of food intake in response to dietary excess [GO:0002023]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28572090, ECO:0000269|PubMed:29046435}.
Q99990	reviewed	VGLL1_HUMAN	Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU)	VGLL1 TDU	Homo sapiens (Human)	258	FUNCTION: May act as a specific coactivator for the mammalian TEFs. {ECO:0000269|PubMed:10518497}.		regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q99996	reviewed	AKAP9_HUMAN	A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao)	AKAP9 AKAP350 AKAP450 KIAA0803	Homo sapiens (Human)	3907	FUNCTION: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}.		cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; maintenance of centrosome location [GO:0051661]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; protein-containing complex localization [GO:0031503]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of Golgi organization [GO:1903358]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to electrical stimulus [GO:0051602]; signal transduction [GO:0007165]	centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic branch [GO:0044307]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; potassium channel complex [GO:0034705]; synaptic membrane [GO:0097060]; voltage-gated potassium channel complex [GO:0008076]	DNA binding [GO:0003677]; molecular adaptor activity [GO:0060090]; potassium channel regulator activity [GO:0015459]; protein kinase A regulatory subunit binding [GO:0034237]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]	centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic branch [GO:0044307]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; potassium channel complex [GO:0034705]; synaptic membrane [GO:0097060]; voltage-gated potassium channel complex [GO:0008076]; DNA binding [GO:0003677]; molecular adaptor activity [GO:0060090]; potassium channel regulator activity [GO:0015459]; protein kinase A regulatory subunit binding [GO:0034237]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; maintenance of centrosome location [GO:0051661]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; protein-containing complex localization [GO:0031503]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of Golgi organization [GO:1903358]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to electrical stimulus [GO:0051602]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745}. Cytoplasm {ECO:0000269|PubMed:9915845}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12270714, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:9915845}. Note=Cytoplasmic in parietal cells (PubMed:9915845). Recruited to the Golgi apparatus by GM130/GOLGA2 (PubMed:25657325). Localization at the centrosome versus Golgi apparatus may be cell line-dependent. In SKBr3 and HEK293F cells, exclusively located at the centrosome (PubMed:29162697). In HeLa, MDA-MB231 and RPE-1 cells, detected at the Golgi apparatus (PubMed:25217626, PubMed:29162697). In SK-BR-3 cells, recruited to the centrosome in the presence of CDK5RAP2 (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:9915845}.
Q99999	reviewed	G3ST1_HUMAN	Galactosylceramide sulfotransferase (GalCer sulfotransferase) (EC 2.8.2.11) (3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase) (3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase) (Cerebroside sulfotransferase)	GAL3ST1 CST	Homo sapiens (Human)	423	FUNCTION: Catalyzes the transfer of a sulfate group to position 3 of non-reducing beta-galactosyl residues in glycerolipids and sphingolipids, therefore participates in the biosynthesis of sulfoglycolipids (PubMed:9030544, PubMed:8830034). Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (PubMed:8830034). Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety (PubMed:8830034). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) (PubMed:8830034). {ECO:0000269|PubMed:8830034, ECO:0000269|PubMed:9030544}.		galactosylceramide biosynthetic process [GO:0006682]; galactosylceramide metabolic process [GO:0006681]; glycerolipid metabolic process [GO:0046486]; myelination [GO:0042552]; protein N-linked glycosylation [GO:0006487]; spermatogenesis [GO:0007283]; sphingolipid metabolic process [GO:0006665]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	galactosylceramide sulfotransferase activity [GO:0001733]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; galactosylceramide sulfotransferase activity [GO:0001733]; sulfotransferase activity [GO:0008146]; galactosylceramide biosynthetic process [GO:0006682]; galactosylceramide metabolic process [GO:0006681]; glycerolipid metabolic process [GO:0046486]; myelination [GO:0042552]; protein N-linked glycosylation [GO:0006487]; spermatogenesis [GO:0007283]; sphingolipid metabolic process [GO:0006665]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9BPU6	reviewed	DPYL5_HUMAN	Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6)	DPYSL5 CRMP5 ULIP6	Homo sapiens (Human)	564	FUNCTION: Involved in the negative regulation of dendrite outgrowth. {ECO:0000269|PubMed:33894126}.		axon guidance [GO:0007411]; negative regulation of dendrite morphogenesis [GO:0050774]; nervous system development [GO:0007399]; signal transduction [GO:0007165]	cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; protein-containing complex [GO:0032991]	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]	cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; protein-containing complex [GO:0032991]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; axon guidance [GO:0007411]; negative regulation of dendrite morphogenesis [GO:0050774]; nervous system development [GO:0007399]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q9BPU9	reviewed	B9D2_HUMAN	B9 domain-containing protein 2 (MKS1-related protein 2)	B9D2 MKSR2	Homo sapiens (Human)	175	FUNCTION: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. {ECO:0000269|PubMed:21763481}.		cilium assembly [GO:0060271]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; membrane [GO:0016020]; MKS complex [GO:0036038]; nucleus [GO:0005634]	gamma-tubulin binding [GO:0043015]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; membrane [GO:0016020]; MKS complex [GO:0036038]; nucleus [GO:0005634]; gamma-tubulin binding [GO:0043015]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19208769}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19208769}. Nucleus {ECO:0000250}.
Q9BPV8	reviewed	P2Y13_HUMAN	P2Y purinoceptor 13 (P2Y13) (G-protein coupled receptor 86) (G-protein coupled receptor 94)	P2RY13 GPR86 GPR94 FKSG77	Homo sapiens (Human)	354	FUNCTION: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system. {ECO:0000269|PubMed:11546776}.	MISCELLANEOUS: Stimulation by ADP in stably transfected CHO cells resulted in inhibition of adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are transduction mechanisms that involve G(i) proteins.	cellular response to organic cyclic compound [GO:0071407]; G protein-coupled receptor signaling pathway [GO:0007186]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	G protein-coupled purinergic nucleotide receptor activity [GO:0045028]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; cellular response to organic cyclic compound [GO:0071407]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9BPW9	reviewed	DHRS9_HUMAN	Dehydrogenase/reductase SDR family member 9 (EC 1.1.1.209) (EC 1.1.1.53) (3-alpha hydroxysteroid dehydrogenase) (3-alpha-HSD) (NADP-dependent retinol dehydrogenase/reductase) (RDH-E2) (RDHL) (Retinol dehydrogenase 15) (EC 1.1.1.105) (Short chain dehydrogenase/reductase family 9C member 4) (Short-chain dehydrogenase/reductase retSDR8) (Tracheobronchial epithelial cell-specific retinol dehydrogenase) (RDH-TBE)	DHRS9 RDH15 SDR9C4 UNQ835/PRO1773	Homo sapiens (Human)	319	FUNCTION: 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed:11294878, PubMed:29541409). Also plays a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed:11304534, PubMed:12618084). Can utilize both NADH and NADPH. {ECO:0000250|UniProtKB:Q8VD48, ECO:0000269|PubMed:11294878, ECO:0000269|PubMed:11304534, ECO:0000269|PubMed:12618084, ECO:0000269|PubMed:29541409}.		9-cis-retinoic acid biosynthetic process [GO:0042904]; androgen metabolic process [GO:0008209]; epithelial cell differentiation [GO:0030855]; progesterone metabolic process [GO:0042448]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	alcohol dehydrogenase (NAD+) activity [GO:0004022]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; NAD-retinol dehydrogenase activity [GO:0004745]; racemase and epimerase activity [GO:0016854]; testosterone dehydrogenase (NAD+) activity [GO:0047035]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; alcohol dehydrogenase (NAD+) activity [GO:0004022]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; NAD-retinol dehydrogenase activity [GO:0004745]; racemase and epimerase activity [GO:0016854]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; 9-cis-retinoic acid biosynthetic process [GO:0042904]; androgen metabolic process [GO:0008209]; epithelial cell differentiation [GO:0030855]; progesterone metabolic process [GO:0042448]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:11294878, ECO:0000269|PubMed:11304534, ECO:0000269|PubMed:12618084}. Endoplasmic reticulum membrane {ECO:0000305}. Note=Associated with microsomal membranes.
Q9BPX1	reviewed	DHB14_HUMAN	17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1)	HSD17B14 DHRS10 SDR3 SDR47C1 UNQ502/PRO474	Homo sapiens (Human)	270	FUNCTION: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro). {ECO:0000269|PubMed:17067289}.		steroid catabolic process [GO:0006706]	cytosol [GO:0005829]	estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; identical protein binding [GO:0042802]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]	cytosol [GO:0005829]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; identical protein binding [GO:0042802]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; steroid catabolic process [GO:0006706]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17067289}.
Q9BPX3	reviewed	CND3_HUMAN	Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog)	NCAPG CAPG NYMEL3	Homo sapiens (Human)	1015	FUNCTION: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.	MISCELLANEOUS: Overexpressed in some cancer lines and some tumor cells.	cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	condensed chromosome [GO:0000793]; condensed chromosome, centromeric region [GO:0000779]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]		condensed chromosome [GO:0000793]; condensed chromosome, centromeric region [GO:0000779]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Q9BPX6	reviewed	MICU1_HUMAN	Calcium uptake protein 1, mitochondrial (Atopy-related autoantigen CALC) (ara CALC) (Calcium-binding atopy-related autoantigen 1) (allergen Hom s 4)	MICU1 CALC CBARA1	Homo sapiens (Human)	476	FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733). {ECO:0000269|PubMed:16002733, ECO:0000269|PubMed:20693986, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23747253, ECO:0000269|PubMed:24313810, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26341627, ECO:0000269|PubMed:26903221, ECO:0000269|PubMed:27099988}.		calcium import into the mitochondrion [GO:0036444]; calcium ion import [GO:0070509]; defense response [GO:0006952]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; protein homooligomerization [GO:0051260]; regulation of cellular hyperosmotic salinity response [GO:1900069]	calcium channel complex [GO:0034704]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]	calcium channel complex [GO:0034704]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; calcium import into the mitochondrion [GO:0036444]; calcium ion import [GO:0070509]; defense response [GO:0006952]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; protein homooligomerization [GO:0051260]; regulation of cellular hyperosmotic salinity response [GO:1900069]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:20693986, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:26387864, ECO:0000269|PubMed:26774479, ECO:0000269|PubMed:27099988, ECO:0000305|PubMed:24231807}; Single-pass membrane protein {ECO:0000255}. Mitochondrion intermembrane space {ECO:0000269|PubMed:23747253, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26387864}.
Q9BPY8	reviewed	HOP_HUMAN	Homeodomain-only protein (Lung cancer-associated Y protein) (Not expressed in choriocarcinoma protein 1) (Odd homeobox protein 1)	HOPX HOD HOP LAGY NECC1 OB1	Homo sapiens (Human)	73	FUNCTION: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). {ECO:0000250|UniProtKB:Q8R1H0, ECO:0000269|PubMed:27708256}.		bundle of His development [GO:0003166]; chaperone-mediated protein complex assembly [GO:0051131]; lung alveolus development [GO:0048286]; negative regulation of cell differentiation [GO:0045596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of skeletal muscle tissue regeneration [GO:0043415]; positive regulation of striated muscle cell differentiation [GO:0051155]; regulation of heart contraction [GO:0008016]; regulation of transcription by RNA polymerase II [GO:0006357]; trophectodermal cell differentiation [GO:0001829]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone deacetylase regulator activity [GO:0035033]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone deacetylase regulator activity [GO:0035033]; bundle of His development [GO:0003166]; chaperone-mediated protein complex assembly [GO:0051131]; lung alveolus development [GO:0048286]; negative regulation of cell differentiation [GO:0045596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of skeletal muscle tissue regeneration [GO:0043415]; positive regulation of striated muscle cell differentiation [GO:0051155]; regulation of heart contraction [GO:0008016]; regulation of transcription by RNA polymerase II [GO:0006357]; trophectodermal cell differentiation [GO:0001829]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8R1H0}. Cytoplasm {ECO:0000250|UniProtKB:Q8R1H0}.
Q9BPZ2	reviewed	SPI2B_HUMAN	Spindlin-2B (Spindlin-like protein 2B) (SPIN-2) (SPIN-2B)	SPIN2B SPIN2	Homo sapiens (Human)	258	FUNCTION: Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846). {ECO:0000269|PubMed:12145692, ECO:0000269|PubMed:29061846}.	MISCELLANEOUS: Overexpression in murine myeloid cell line 32Dcl3 causes G2/M arrest.	apoptotic process [GO:0006915]; cell cycle [GO:0007049]; gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	methylated histone binding [GO:0035064]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; methylated histone binding [GO:0035064]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12145692}.
Q9BPZ3	reviewed	PAIP2_HUMAN	Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2)	PAIP2 PAIP2A HSPC218	Homo sapiens (Human)	127	FUNCTION: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. {ECO:0000269|PubMed:11172725}.		memory [GO:0007613]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; regulation of long-term synaptic potentiation [GO:1900271]; spermatogenesis [GO:0007283]; translation [GO:0006412]	cytoplasm [GO:0005737]	mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; translation repressor activity [GO:0030371]	cytoplasm [GO:0005737]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; translation repressor activity [GO:0030371]; memory [GO:0007613]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; regulation of long-term synaptic potentiation [GO:1900271]; spermatogenesis [GO:0007283]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11172725}.
Q9BPZ7	reviewed	SIN1_HUMAN	Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1)	MAPKAP1 MIP1 SIN1	Homo sapiens (Human)	522	FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. {ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:23727834}.	MISCELLANEOUS: [Isoform 4]: Not involved in a TORC2 complex. {ECO:0000305}.	cellular response to nutrient levels [GO:0031669]; cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of cell growth [GO:0030307]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of cellular response to oxidative stress [GO:1900407]; substantia nigra development [GO:0021762]; TORC2 signaling [GO:0038203]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; TORC2 complex [GO:0031932]	molecular adaptor activity [GO:0060090]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; TORC2 complex [GO:0031932]; molecular adaptor activity [GO:0060090]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]; cellular response to nutrient levels [GO:0031669]; cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of cell growth [GO:0030307]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of cellular response to oxidative stress [GO:1900407]; substantia nigra development [GO:0021762]; TORC2 signaling [GO:0038203]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
Q9BQ04	reviewed	RBM4B_HUMAN	RNA-binding protein 4B (RNA-binding motif protein 30) (RNA-binding motif protein 4B) (RNA-binding protein 30)	RBM4B RBM30	Homo sapiens (Human)	359	FUNCTION: Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity). {ECO:0000250}.		circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of gene expression [GO:0010628]; regulation of translation [GO:0006417]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of gene expression [GO:0010628]; regulation of translation [GO:0006417]	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus.
Q9BQ15	reviewed	SOSB1_HUMAN	SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1)	NABP2 OBFC2B SSB1 LP3587	Homo sapiens (Human)	211	FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint (PubMed:25249620). In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501, ECO:0000269|PubMed:25249620}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; establishment of protein localization to telomere [GO:0070200]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of telomere capping [GO:1904355]; response to ionizing radiation [GO:0010212]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876]	DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]; G-rich strand telomeric DNA binding [GO:0098505]; single-stranded DNA binding [GO:0003697]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]; G-rich strand telomeric DNA binding [GO:0098505]; single-stranded DNA binding [GO:0003697]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; establishment of protein localization to telomere [GO:0070200]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of telomere capping [GO:1904355]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.
Q9BQ16	reviewed	TICN3_HUMAN	Testican-3 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3)	SPOCK3 TICN3 UNQ409/PRO771	Homo sapiens (Human)	436	FUNCTION: May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.		negative regulation of cell motility [GO:2000146]; negative regulation of endopeptidase activity [GO:0010951]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; metalloendopeptidase inhibitor activity [GO:0008191]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; metalloendopeptidase inhibitor activity [GO:0008191]; negative regulation of cell motility [GO:2000146]; negative regulation of endopeptidase activity [GO:0010951]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q9BQ24	reviewed	ZFY21_HUMAN	Zinc finger FYVE domain-containing protein 21 (ZF21)	ZFYVE21	Homo sapiens (Human)	234	FUNCTION: Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression. {ECO:0000269|PubMed:20439989, ECO:0000269|PubMed:21768110}.			endosome [GO:0005768]; focal adhesion [GO:0005925]	metal ion binding [GO:0046872]	endosome [GO:0005768]; focal adhesion [GO:0005925]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cytoplasmic vesicle. Endosome. Note=Within cytoplasmic vesicles, partially colocalizes with EEA1, an endosomal marker.
Q9BQ31	reviewed	KCNS3_HUMAN	Potassium voltage-gated channel subfamily S member 3 (Delayed-rectifier K(+) channel alpha subunit 3) (Voltage-gated potassium channel subunit Kv9.3)	KCNS3	Homo sapiens (Human)	491	FUNCTION: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). {ECO:0000250|UniProtKB:O88759, ECO:0000269|PubMed:10484328}.		potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10484328}; Multi-pass membrane protein {ECO:0000305}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 (PubMed:10484328). {ECO:0000269|PubMed:10484328}.
Q9BQ39	reviewed	DDX50_HUMAN	ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2)	DDX50	Homo sapiens (Human)	737				membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Q9BQ50	reviewed	TREX2_HUMAN	Three prime repair exonuclease 2 (EC 3.1.11.2) (3'-5' exonuclease TREX2)	TREX2	Homo sapiens (Human)	236	FUNCTION: Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair. {ECO:0000269|PubMed:11279105}.	MISCELLANEOUS: [Isoform 1]: Only supported by readthrough transcripts formed via the splicing of exons from UCHL5IP and TREX2 genes. {ECO:0000305}.	DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	3'-5'-DNA exonuclease activity [GO:0008296]; DNA binding [GO:0003677]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; magnesium ion binding [GO:0000287]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; 3'-5'-DNA exonuclease activity [GO:0008296]; DNA binding [GO:0003677]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; magnesium ion binding [GO:0000287]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BQ51	reviewed	PD1L2_HUMAN	Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)	PDCD1LG2 B7DC CD273 PDCD1L2 PDL2	Homo sapiens (Human)	273	FUNCTION: Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). {ECO:0000250}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of type II interferon production [GO:0032689]; positive regulation of T cell proliferation [GO:0042102]; T cell costimulation [GO:0031295]	endomembrane system [GO:0012505]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]		endomembrane system [GO:0012505]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of type II interferon production [GO:0032689]; positive regulation of T cell proliferation [GO:0042102]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305|PubMed:15253154}.; SUBCELLULAR LOCATION: [Isoform 2]: Endomembrane system {ECO:0000269|PubMed:15253154}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15253154}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9WUL5, ECO:0000305|PubMed:15340161}.
Q9BQ52	reviewed	RNZ2_HUMAN	Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2)	ELAC2 HPC2	Homo sapiens (Human)	826	FUNCTION: Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694). {ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:24703694}.		mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA processing [GO:0090646]; tRNA 3'-end processing [GO:0042780]; tRNA catabolic process [GO:0016078]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-tRNA processing endoribonuclease activity [GO:0042781]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; tRNA-specific ribonuclease activity [GO:0004549]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-tRNA processing endoribonuclease activity [GO:0042781]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; tRNA-specific ribonuclease activity [GO:0004549]; mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA processing [GO:0090646]; tRNA 3'-end processing [GO:0042780]; tRNA catabolic process [GO:0016078]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21593607}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:24703694}. Nucleus {ECO:0000269|PubMed:21593607}. Note=Mainly mitochondrial.
Q9BQ61	reviewed	TRIR_HUMAN	Telomerase RNA component interacting RNase (EC 3.1.13.-) (Exoribonuclease TRIR)	TRIR C19orf43	Homo sapiens (Human)	176	FUNCTION: Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335). {ECO:0000269|PubMed:28322335}.		rRNA catabolic process [GO:0016075]		3'-5' exonuclease activity [GO:0008408]; 5'-3' exonuclease activity [GO:0008409]; RNA binding [GO:0003723]	3'-5' exonuclease activity [GO:0008408]; 5'-3' exonuclease activity [GO:0008409]; RNA binding [GO:0003723]; rRNA catabolic process [GO:0016075]	
Q9BQ65	reviewed	USB1_HUMAN	U6 snRNA phosphodiesterase 1 (hUsb1) (3'-5' RNA exonuclease USB1) (EC 4.6.1.-) (Mutated in poikiloderma with neutropenia protein 1) (Mutated in PN protein 1) (hMpn1)	USB1 C16orf57 Mpn1	Homo sapiens (Human)	265	FUNCTION: 3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate (PubMed:23022480, PubMed:22899009, PubMed:26213367, PubMed:31832688, PubMed:23190533, PubMed:28887445, PubMed:30215753). Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation (PubMed:23022480, PubMed:22899009, PubMed:26213367, PubMed:31832688, PubMed:23190533, PubMed:28887445, PubMed:30215753). In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1 (PubMed:26213367). {ECO:0000269|PubMed:22899009, ECO:0000269|PubMed:23022480, ECO:0000269|PubMed:23190533, ECO:0000269|PubMed:26213367, ECO:0000269|PubMed:28887445, ECO:0000269|PubMed:30215753, ECO:0000269|PubMed:31832688}.		RNA splicing [GO:0008380]; snRNA 3'-end processing [GO:0034472]; U6 snRNA 3'-end processing [GO:0034477]	intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5'-RNA exonuclease activity [GO:0000175]; lyase activity [GO:0016829]; poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends [GO:1990838]	intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5'-RNA exonuclease activity [GO:0000175]; lyase activity [GO:0016829]; poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends [GO:1990838]; RNA splicing [GO:0008380]; snRNA 3'-end processing [GO:0034472]; U6 snRNA 3'-end processing [GO:0034477]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03040, ECO:0000269|PubMed:22899009, ECO:0000269|PubMed:23022480}.
Q9BQ66	reviewed	KR412_HUMAN	Keratin-associated protein 4-12 (Keratin-associated protein 4.12) (Ultrahigh sulfur keratin-associated protein 4.12)	KRTAP4-12 KAP4.12 KRTAP4.12	Homo sapiens (Human)	201	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q9BQ67	reviewed	GRWD1_HUMAN	Glutamate-rich WD repeat-containing protein 1	GRWD1 GRWD KIAA1942 WDR28	Homo sapiens (Human)	446	FUNCTION: Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). {ECO:0000269|PubMed:25990725}.		DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; ribosome biogenesis [GO:0042254]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; DNA replication origin binding [GO:0003688]; histone binding [GO:0042393]; RNA binding [GO:0003723]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; DNA replication origin binding [GO:0003688]; histone binding [GO:0042393]; RNA binding [GO:0003723]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:25990725}. Chromosome {ECO:0000269|PubMed:25990725}. Note=Present in the nucleus throughout interphase and is detached from chromatin at the onset of mitosis and rebinds at telophase when the pre-replication complexes (pre-RC) is formed (PubMed:25990725). {ECO:0000269|PubMed:25990725}.
Q9BQ69	reviewed	MACD1_HUMAN	ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)	MACROD1 LRP16	Homo sapiens (Human)	325	FUNCTION: Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed:19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed:17893710, PubMed:17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed:17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed:17893710). Enhances ESR1-mediated transcription activity (PubMed:17914104). {ECO:0000269|PubMed:17893710, ECO:0000269|PubMed:17914104, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19403568, ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712, ECO:0000269|PubMed:23474714}.	MISCELLANEOUS: Overexpression may promote MCF-7 cells proliferation. There is an approximate one-third increase of the invasive capacity of MACROD1-overexpressing cells. The expression of CDH1 is repressed by MACROD1. Further analysis demonstrates that MACROD1 inhibits CDH1 transactivation in a dose-dependent manner. Inhibition is abolished by estrogen deprivation, indicating that the down-regulation of CDH1 transcription by MACROD1 requires ESR1 mediation. Binding of ESR1 to the CDH1 promoter is antagonized by MACROD1, suggesting that MACROD1 could interfere with ESR1-mediated transcription. Knockdown of MACROD1 leads to impaired AR function and greatly attenuates the coactivation of AR by other AR coactivators such as UXT and NCOA1. This interference also markedly inhibits the androgen-stimulated proliferation of androgen-sensitive LNCaP prostate cancer cells. MACROD1 knockdown does not significantly affect the growth rate of AR-negative PC-3 prostate cancer cells. {ECO:0000269|PubMed:12790785}.	DNA damage response [GO:0006974]; peptidyl-glutamate ADP-deribosylation [GO:0140291]; protein de-ADP-ribosylation [GO:0051725]; purine nucleoside metabolic process [GO:0042278]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ADP-ribosylglutamate hydrolase activity [GO:0140293]; deacetylase activity [GO:0019213]; hydrolase activity, acting on glycosyl bonds [GO:0016798]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ADP-ribosylglutamate hydrolase activity [GO:0140293]; deacetylase activity [GO:0019213]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; DNA damage response [GO:0006974]; peptidyl-glutamate ADP-deribosylation [GO:0140291]; protein de-ADP-ribosylation [GO:0051725]; purine nucleoside metabolic process [GO:0042278]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23474712}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. {ECO:0000269|PubMed:23474712}.
Q9BQ70	reviewed	TCF25_HUMAN	Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25)	TCF25 KIAA1049 NULP1 FKSG26	Homo sapiens (Human)	676	FUNCTION: Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831). Also acts as a transcriptional repressor: represses transcription of SRF in vitro and so may play a role in heart development (PubMed:16574069). May play a role in cell death control (By similarity). {ECO:0000250|UniProtKB:Q8R3L2, ECO:0000269|PubMed:16574069, ECO:0000269|PubMed:30244831}.		heart development [GO:0007507]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of protein K48-linked ubiquitination [GO:0061945]; rescue of stalled ribosome [GO:0072344]	cytosol [GO:0005829]; nucleus [GO:0005634]; RQC complex [GO:1990112]	DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714]	cytosol [GO:0005829]; nucleus [GO:0005634]; RQC complex [GO:1990112]; DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714]; heart development [GO:0007507]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of protein K48-linked ubiquitination [GO:0061945]; rescue of stalled ribosome [GO:0072344]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16574069, ECO:0000269|PubMed:18068114}. Cytoplasm, cytosol {ECO:0000269|PubMed:18068114}. Note=Mainly nuclear. {ECO:0000269|PubMed:18068114}.
Q9BQ83	reviewed	SLX1_HUMAN	Structure-specific endonuclease subunit SLX1 (EC 3.1.-.-) (GIY-YIG domain-containing protein 1)	SLX1A GIYD1 SLX1; SLX1B GIYD2 SLX1	Homo sapiens (Human)	275	FUNCTION: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. {ECO:0000255|HAMAP-Rule:MF_03100, ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.		DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of t-circle formation [GO:1904431]; t-circle formation [GO:0090656]; telomere maintenance via telomere lengthening [GO:0010833]; telomeric D-loop disassembly [GO:0061820]	nucleoplasm [GO:0005654]; Slx1-Slx4 complex [GO:0033557]	5'-flap endonuclease activity [GO:0017108]; crossover junction DNA endonuclease activity [GO:0008821]; metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; Slx1-Slx4 complex [GO:0033557]; 5'-flap endonuclease activity [GO:0017108]; crossover junction DNA endonuclease activity [GO:0008821]; metal ion binding [GO:0046872]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of t-circle formation [GO:1904431]; t-circle formation [GO:0090656]; telomere maintenance via telomere lengthening [GO:0010833]; telomeric D-loop disassembly [GO:0061820]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03100, ECO:0000269|PubMed:19596236}.
Q9BQ87	reviewed	TBL1Y_HUMAN	F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked)	TBL1Y TBL1	Homo sapiens (Human)	522	FUNCTION: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity). {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription corepressor activity [GO:0003714]	histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription corepressor activity [GO:0003714]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30341416}.
Q9BQ89	reviewed	F110A_HUMAN	Protein FAM110A	FAM110A C20orf55 F10	Homo sapiens (Human)	295			mitotic spindle organization [GO:0007052]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]		cell cortex [GO:0005938]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; mitotic spindle organization [GO:0007052]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17499476}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17499476}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:17499476}. Note=Distributed throughout the cytoplasm during mitosis, accumulating at spindle poles.
Q9BQ90	reviewed	KLDC3_HUMAN	Kelch domain-containing protein 3 (Testis intracellular mediator protein)	KLHDC3 PEAS	Homo sapiens (Human)	382	FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:29775578). The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons (PubMed:29779948, PubMed:29775578). The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine (PubMed:26138980). May be involved in meiotic recombination process (PubMed:12606021). {ECO:0000269|PubMed:12606021, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	chromatin [GO:0000785]; Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	chromatin [GO:0000785]; Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12606021}.
Q9BQ95	reviewed	ECSIT_HUMAN	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC)	ECSIT	Homo sapiens (Human)	431	FUNCTION: Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs (PubMed:25355951, PubMed:31281713). Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression (PubMed:25355951). Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion (PubMed:25228397). Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250, ECO:0000269|PubMed:25228397, ECO:0000269|PubMed:25355951, ECO:0000269|PubMed:31281713}.; FUNCTION: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. {ECO:0000269|PubMed:32320651}.		innate immune response [GO:0045087]; mitochondrial respiratory chain complex I assembly [GO:0032981]; regulation of oxidoreductase activity [GO:0051341]; regulation of protein complex stability [GO:0061635]; toll-like receptor 4 signaling pathway [GO:0034142]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; molecular adaptor activity [GO:0060090]; innate immune response [GO:0045087]; mitochondrial respiratory chain complex I assembly [GO:0032981]; regulation of oxidoreductase activity [GO:0051341]; regulation of protein complex stability [GO:0061635]; toll-like receptor 4 signaling pathway [GO:0034142]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17344420, ECO:0000269|PubMed:25355951}. Nucleus {ECO:0000269|PubMed:17344420, ECO:0000269|PubMed:25355951}. Mitochondrion {ECO:0000269|PubMed:17344420, ECO:0000269|PubMed:25228397}.
Q9BQA1	reviewed	MEP50_HUMAN	Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)	WDR77 MEP50 WD45 HKMT1069 Nbla10071	Homo sapiens (Human)	342	FUNCTION: Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334). {ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}.		epithelial cell proliferation involved in prostate gland development [GO:0060767]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; oocyte axis specification [GO:0007309]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of transcription by RNA polymerase II [GO:0006357]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; spliceosomal snRNP assembly [GO:0000387]; ubiquitin-dependent protein catabolic process [GO:0006511]	Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	methyl-CpG binding [GO:0008327]; nuclear receptor coactivator activity [GO:0030374]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; methyl-CpG binding [GO:0008327]; nuclear receptor coactivator activity [GO:0030374]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; oocyte axis specification [GO:0007309]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of transcription by RNA polymerase II [GO:0006357]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; spliceosomal snRNP assembly [GO:0000387]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17437848, ECO:0000269|PubMed:21081503}. Cytoplasm {ECO:0000269|PubMed:17437848, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:27337956}. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors (PubMed:17437848). {ECO:0000269|PubMed:17437848}.
Q9BQA5	reviewed	HINFP_HUMAN	Histone H4 transcription factor (Histone nuclear factor P) (HiNF-P) (MBD2-interacting zinc finger protein) (Methyl-CpG-binding protein 2-interacting zinc finger protein)	HINFP MIZF ZNF743	Homo sapiens (Human)	517	FUNCTION: Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. {ECO:0000269|PubMed:11553631, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14752047, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:18850719}.		anatomical structure development [GO:0048856]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; establishment of protein localization [GO:0045184]; G1/S transition of mitotic cell cycle [GO:0000082]; in utero embryonic development [GO:0001701]; myoblast differentiation [GO:0045445]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	Cajal body [GO:0015030]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	Cajal body [GO:0015030]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure development [GO:0048856]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; establishment of protein localization [GO:0045184]; G1/S transition of mitotic cell cycle [GO:0000082]; in utero embryonic development [GO:0001701]; myoblast differentiation [GO:0045445]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11553631, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:18850719}. Note=Associated with discrete nuclear foci.
Q9BQA9	reviewed	CYBC1_HUMAN	Cytochrome b-245 chaperone 1 (Essential for reactive oxygen species protein) (Eros)	CYBC1 C17orf62 EROS	Homo sapiens (Human)	187	FUNCTION: Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (PubMed:30361506). Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity). {ECO:0000250|UniProtKB:Q3TYS2, ECO:0000269|PubMed:30361506}.		innate immune response [GO:0045087]; respiratory burst after phagocytosis [GO:0045728]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; innate immune response [GO:0045087]; respiratory burst after phagocytosis [GO:0045728]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28351984}; Single-pass membrane protein {ECO:0000305}.
Q9BQB4	reviewed	SOST_HUMAN	Sclerostin	SOST UNQ2976/PRO7455/PRO7476	Homo sapiens (Human)	213	FUNCTION: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. {ECO:0000269|PubMed:15908424}.		BMP signaling pathway [GO:0030509]; canonical Wnt signaling pathway [GO:0060070]; cellular response to parathyroid hormone stimulus [GO:0071374]; localization [GO:0051179]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of Wnt signaling pathway [GO:0030178]; ossification [GO:0001503]; positive regulation of DNA-templated transcription [GO:0045893]; response to mechanical stimulus [GO:0009612]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; protein-containing complex [GO:0032991]	BMP binding [GO:0036122]; carbohydrate binding [GO:0030246]; DNA-binding transcription factor binding [GO:0140297]; heparin binding [GO:0008201]; molecular function inhibitor activity [GO:0140678]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; protein-containing complex [GO:0032991]; BMP binding [GO:0036122]; carbohydrate binding [GO:0030246]; DNA-binding transcription factor binding [GO:0140297]; heparin binding [GO:0008201]; molecular function inhibitor activity [GO:0140678]; BMP signaling pathway [GO:0030509]; canonical Wnt signaling pathway [GO:0060070]; cellular response to parathyroid hormone stimulus [GO:0071374]; localization [GO:0051179]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of Wnt signaling pathway [GO:0030178]; ossification [GO:0001503]; positive regulation of DNA-templated transcription [GO:0045893]; response to mechanical stimulus [GO:0009612]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}.
Q9BQB6	reviewed	VKOR1_HUMAN	Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1)	VKORC1 VKOR MSTP134 MSTP576 UNQ308/PRO351	Homo sapiens (Human)	163	FUNCTION: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:14765195, ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610, ECO:0000269|PubMed:33154105}.		blood coagulation [GO:0007596]; bone development [GO:0060348]; peptidyl-glutamic acid carboxylation [GO:0017187]; positive regulation of coagulation [GO:0050820]; regulation of blood coagulation [GO:0030193]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	quinone binding [GO:0048038]; vitamin-K-epoxide reductase (warfarin-insensitive) activity [GO:0047058]; vitamin-K-epoxide reductase (warfarin-sensitive) activity [GO:0047057]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; quinone binding [GO:0048038]; vitamin-K-epoxide reductase (warfarin-insensitive) activity [GO:0047058]; vitamin-K-epoxide reductase (warfarin-sensitive) activity [GO:0047057]; blood coagulation [GO:0007596]; bone development [GO:0060348]; peptidyl-glutamic acid carboxylation [GO:0017187]; positive regulation of coagulation [GO:0050820]; regulation of blood coagulation [GO:0030193]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}; Multi-pass membrane protein {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20696932, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610, ECO:0000269|PubMed:33154105}.
Q9BQC3	reviewed	DPH2_HUMAN	2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)	DPH2 DPH2L2	Homo sapiens (Human)	489	FUNCTION: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:32576952). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). {ECO:0000250|UniProtKB:P32461, ECO:0000269|PubMed:32576952}.		protein histidyl modification to diphthamide [GO:0017183]	cytosol [GO:0005829]; protein-containing complex [GO:0032991]	2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; protein-containing complex [GO:0032991]; 2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; protein histidyl modification to diphthamide [GO:0017183]	
Q9BQD3	reviewed	KXDL1_HUMAN	KxDL motif-containing protein 1	KXD1 C19orf50	Homo sapiens (Human)	176	FUNCTION: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May be involved in the biogenesis of lysosome-related organelles such as melanosomes (By similarity). {ECO:0000250|UniProtKB:Q80XH1, ECO:0000269|PubMed:25898167}.		lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]; vesicle-mediated transport [GO:0016192]	BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]		BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000305|PubMed:25898167}.
Q9BQD7	reviewed	ANKMT_HUMAN	Adenine nucleotide translocase lysine N-methyltransferase (ANT-KMT) (EC 2.1.1.-)	ANTKMT C16orf24 FAM173A RJD7	Homo sapiens (Human)	235	FUNCTION: Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). Probably also trimethylates ANT1/SLC25A4 (PubMed:31213526). {ECO:0000269|PubMed:31213526}.		peptidyl-lysine trimethylation [GO:0018023]; regulation of mitochondrial ATP synthesis coupled proton transport [GO:1905706]	mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279]	mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279]; peptidyl-lysine trimethylation [GO:0018023]; regulation of mitochondrial ATP synthesis coupled proton transport [GO:1905706]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:31213526}; Single-pass membrane protein {ECO:0000255}.
Q9BQE3	reviewed	TBA1C_HUMAN	Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]	TUBA1C TUBA6	Homo sapiens (Human)	449	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		cell division [GO:0051301]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; membrane raft [GO:0045121]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; vesicle [GO:0031982]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; membrane raft [GO:0045121]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; vesicle [GO:0031982]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; cell division [GO:0051301]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
Q9BQE4	reviewed	SELS_HUMAN	Selenoprotein S (SelS) (VCP-interacting membrane protein)	SELENOS SELS VIMP AD-015 SBBI8	Homo sapiens (Human)	189	FUNCTION: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. {ECO:0000269|PubMed:15215856}.		cell redox homeostasis [GO:0045454]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; establishment of protein localization [GO:0045184]; negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of glucose import [GO:0046325]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of tumor necrosis factor production [GO:0032720]; regulation of gluconeogenesis [GO:0006111]; regulation of nitric oxide metabolic process [GO:0080164]; response to glucose [GO:0009749]; response to redox state [GO:0051775]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasmic microtubule [GO:0005881]; Derlin-1 retrotranslocation complex [GO:0036513]; Derlin-1-VIMP complex [GO:0036502]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; low-density lipoprotein particle [GO:0034362]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361]	antioxidant activity [GO:0016209]; ATPase binding [GO:0051117]; enzyme binding [GO:0019899]; signaling receptor activity [GO:0038023]; ubiquitin-specific protease binding [GO:1990381]	cytoplasmic microtubule [GO:0005881]; Derlin-1 retrotranslocation complex [GO:0036513]; Derlin-1-VIMP complex [GO:0036502]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; low-density lipoprotein particle [GO:0034362]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361]; antioxidant activity [GO:0016209]; ATPase binding [GO:0051117]; enzyme binding [GO:0019899]; signaling receptor activity [GO:0038023]; ubiquitin-specific protease binding [GO:1990381]; cell redox homeostasis [GO:0045454]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; establishment of protein localization [GO:0045184]; negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of glucose import [GO:0046325]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of tumor necrosis factor production [GO:0032720]; regulation of gluconeogenesis [GO:0006111]; regulation of nitric oxide metabolic process [GO:0080164]; response to glucose [GO:0009749]; response to redox state [GO:0051775]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm {ECO:0000250}.
Q9BQE5	reviewed	APOL2_HUMAN	Apolipoprotein L2 (Apolipoprotein L-II) (ApoL-II)	APOL2	Homo sapiens (Human)	337	FUNCTION: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.		acute-phase response [GO:0006953]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; maternal process involved in female pregnancy [GO:0060135]	endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020]	high-density lipoprotein particle binding [GO:0008035]; lipid binding [GO:0008289]; signaling receptor binding [GO:0005102]	endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020]; high-density lipoprotein particle binding [GO:0008035]; lipid binding [GO:0008289]; signaling receptor binding [GO:0005102]; acute-phase response [GO:0006953]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; maternal process involved in female pregnancy [GO:0060135]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q9BQE9	reviewed	BCL7B_HUMAN	B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3)	BCL7B	Homo sapiens (Human)	202	FUNCTION: Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}.		apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; SWI/SNF complex [GO:0016514]	actin binding [GO:0003779]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; SWI/SNF complex [GO:0016514]; actin binding [GO:0003779]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	
Q9BQF6	reviewed	SENP7_HUMAN	Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7)	SENP7 KIAA1707 SSP2 SUSP2	Homo sapiens (Human)	1050	FUNCTION: Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}.		antiviral innate immune response [GO:0140374]; protein desumoylation [GO:0016926]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	SUMO-specific endopeptidase activity [GO:0070139]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; SUMO-specific endopeptidase activity [GO:0070139]; antiviral innate immune response [GO:0140374]; protein desumoylation [GO:0016926]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BUH8}.
Q9BQG0	reviewed	MBB1A_HUMAN	Myb-binding protein 1A	MYBBP1A P160	Homo sapiens (Human)	1328	FUNCTION: May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}.	MISCELLANEOUS: [Isoform 2]: May be due to competing donor and acceptor splice sites. {ECO:0000305}.	cellular response to glucose starvation [GO:0042149]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of DNA-templated transcription [GO:0045892]; osteoblast differentiation [GO:0001649]; positive regulation of anoikis [GO:2000210]; positive regulation of histone acetylation [GO:0035066]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1 to G0 transition [GO:1903450]; respiratory electron transport chain [GO:0022904]; ribosome biogenesis [GO:0042254]	B-WICH complex [GO:0110016]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	E-box binding [GO:0070888]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; transcription corepressor activity [GO:0003714]	B-WICH complex [GO:0110016]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; E-box binding [GO:0070888]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; transcription corepressor activity [GO:0003714]; cellular response to glucose starvation [GO:0042149]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of DNA-templated transcription [GO:0045892]; osteoblast differentiation [GO:0001649]; positive regulation of anoikis [GO:2000210]; positive regulation of histone acetylation [GO:0035066]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1 to G0 transition [GO:1903450]; respiratory electron transport chain [GO:0022904]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:12429849}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar. {ECO:0000250|UniProtKB:Q7TPV4}.
Q9BQG1	reviewed	SYT3_HUMAN	Synaptotagmin-3 (Synaptotagmin III) (SytIII)	SYT3	Homo sapiens (Human)	590	FUNCTION: Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P40748, ECO:0000269|PubMed:23999003}.		calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]	endosome [GO:0005768]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]	endosome [GO:0005768]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P40748}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Q9BQG2	reviewed	NUD12_HUMAN	NAD-capped RNA hydrolase NUDT12 (DeNADding enzyme NUDT12) (EC 3.6.1.-) (NADH pyrophosphatase NUDT12) (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12)	NUDT12	Homo sapiens (Human)	462	FUNCTION: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:31101919, PubMed:31875550). The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:31101919). Preferentially acts on NAD-capped transcripts in response to nutrient stress (PubMed:31101919). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP (PubMed:12790796). May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (PubMed:12790796). Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity). {ECO:0000250|UniProtKB:Q9DCN1, ECO:0000269|PubMed:12790796, ECO:0000269|PubMed:31101919, ECO:0000269|PubMed:31875550}.		circadian regulation of gene expression [GO:0032922]; methylguanosine-cap decapping [GO:0110156]; mRNA catabolic process [GO:0006402]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; NAD catabolic process [GO:0019677]; NAD-cap decapping [GO:0110155]; NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	magnesium ion binding [GO:0000287]; NAD+ diphosphatase activity [GO:0000210]; NADH pyrophosphatase activity [GO:0035529]; phosphodiesterase decapping endonuclease activity [GO:1990174]; RNA NAD-cap (NMN-forming) hydrolase activity [GO:0110153]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; magnesium ion binding [GO:0000287]; NAD+ diphosphatase activity [GO:0000210]; NADH pyrophosphatase activity [GO:0035529]; phosphodiesterase decapping endonuclease activity [GO:1990174]; RNA NAD-cap (NMN-forming) hydrolase activity [GO:0110153]; zinc ion binding [GO:0008270]; circadian regulation of gene expression [GO:0032922]; methylguanosine-cap decapping [GO:0110156]; mRNA catabolic process [GO:0006402]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; NAD catabolic process [GO:0019677]; NAD-cap decapping [GO:0110155]; NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12790796}. Peroxisome {ECO:0000269|PubMed:12790796}. Cytoplasmic granule {ECO:0000269|PubMed:31875550}. Note=Localizes to cytoplasmic granules in the presence of BLMH. {ECO:0000269|PubMed:31875550}.
Q9BQI0	reviewed	AIF1L_HUMAN	Allograft inflammatory factor 1-like (Ionized calcium-binding adapter molecule 2)	AIF1L C9orf58 IBA2 UNQ672/PRO1306	Homo sapiens (Human)	150	FUNCTION: Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function. {ECO:0000269|PubMed:18699778}.		actin filament bundle assembly [GO:0051017]; ruffle assembly [GO:0097178]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; ruffle membrane [GO:0032587]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; ruffle membrane [GO:0032587]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; actin filament bundle assembly [GO:0051017]; ruffle assembly [GO:0097178]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18699778}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18699778}; Peripheral membrane protein {ECO:0000269|PubMed:18699778}; Cytoplasmic side {ECO:0000269|PubMed:18699778}. Note=Colocalizes with F-actin. Partially relocates to membrane ruffles in response to invading bacteria.
Q9BQI3	reviewed	E2AK1_HUMAN	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase)	EIF2AK1 HRI KIAA1369 PRO1362	Homo sapiens (Human)	630	FUNCTION: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707, PubMed:37327776). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707, PubMed:37327776). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707, PubMed:37327776). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Iron deficiency also triggers activation by full-length DELE1 (PubMed:37327776). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). {ECO:0000250|UniProtKB:Q9Z2R9, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:32197074}.		acute inflammatory response [GO:0002526]; establishment of localization in cell [GO:0051649]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; macrophage differentiation [GO:0030225]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hemoglobin biosynthetic process [GO:0046986]; negative regulation of translational initiation by iron [GO:0045993]; phagocytosis [GO:0006909]; protein autophosphorylation [GO:0046777]; protoporphyrinogen IX metabolic process [GO:0046501]; regulation of eIF2 alpha phosphorylation by heme [GO:0010999]; response to iron ion starvation [GO:1990641]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; heme binding [GO:0020037]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; heme binding [GO:0020037]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; acute inflammatory response [GO:0002526]; establishment of localization in cell [GO:0051649]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; macrophage differentiation [GO:0030225]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hemoglobin biosynthetic process [GO:0046986]; negative regulation of translational initiation by iron [GO:0045993]; phagocytosis [GO:0006909]; protein autophosphorylation [GO:0046777]; protoporphyrinogen IX metabolic process [GO:0046501]; regulation of eIF2 alpha phosphorylation by heme [GO:0010999]; response to iron ion starvation [GO:1990641]	
Q9BQI4	reviewed	CCDC3_HUMAN	Coiled-coil domain-containing protein 3 (Fat/vessel-derived secretory protein) (Favine)	CCDC3	Homo sapiens (Human)	270	FUNCTION: Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9D6Y1, ECO:0000269|PubMed:25193116}.		lipid biosynthetic process [GO:0008610]; negative regulation of gene expression [GO:0010629]; negative regulation of lipid biosynthetic process [GO:0051055]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of lipid biosynthetic process [GO:0046889]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]		endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid biosynthetic process [GO:0008610]; negative regulation of gene expression [GO:0010629]; negative regulation of lipid biosynthetic process [GO:0051055]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of lipid biosynthetic process [GO:0046889]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9D6Y1}.
Q9BQI5	reviewed	SGIP1_HUMAN	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)	SGIP1	Homo sapiens (Human)	828	FUNCTION: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}.		clathrin-dependent endocytosis [GO:0072583]; energy homeostasis [GO:0097009]; positive regulation of feeding behavior [GO:2000253]; positive regulation of receptor-mediated endocytosis [GO:0048260]; response to dietary excess [GO:0002021]	AP-2 adaptor complex [GO:0030122]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	microtubule binding [GO:0008017]; phospholipid binding [GO:0005543]; SH3 domain binding [GO:0017124]	AP-2 adaptor complex [GO:0030122]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; microtubule binding [GO:0008017]; phospholipid binding [GO:0005543]; SH3 domain binding [GO:0017124]; clathrin-dependent endocytosis [GO:0072583]; energy homeostasis [GO:0097009]; positive regulation of feeding behavior [GO:2000253]; positive regulation of receptor-mediated endocytosis [GO:0048260]; response to dietary excess [GO:0002021]	SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000305|PubMed:20946875}; Peripheral membrane protein {ECO:0000305|PubMed:20946875}; Cytoplasmic side {ECO:0000305|PubMed:20946875}.
Q9BQI6	reviewed	SLF1_HUMAN	SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1)	SLF1 ANKRD32 BRCTD1	Homo sapiens (Human)	1058	FUNCTION: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565, PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}.		chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]	protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25931565}. Cytoplasm {ECO:0000250|UniProtKB:Q8R3P9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8R3P9}. Note=Relocalizes with RAD18 to nuclear foci in response to DNA damage. Colocalizes with RAD18 in the nucleus and to centrosomes (By similarity). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). {ECO:0000250|UniProtKB:Q8R3P9, ECO:0000269|PubMed:25931565}.
Q9BQJ4	reviewed	TMM47_HUMAN	Transmembrane protein 47 (Brain cell membrane protein 1) (Transmembrane 4 superfamily member 10)	TMEM47 BCMP1 TM4SF10	Homo sapiens (Human)	181	FUNCTION: Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity). {ECO:0000250|UniProtKB:Q9JJG6, ECO:0000250|UniProtKB:Q9XSV3}.		cell-cell adhesion [GO:0098609]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]		adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; cell-cell adhesion [GO:0098609]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9XSV3}. Note=Colocalizes with FYB1 at cell-cell contacts in podocytes. {ECO:0000250|UniProtKB:Q9JJG6}.
Q9BQK8	reviewed	LPIN3_HUMAN	Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like)	LPIN3 LIPN3L	Homo sapiens (Human)	851	FUNCTION: Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. {ECO:0000250|UniProtKB:Q99PI4}.		cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432]	endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713]	endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713]; cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BQL6	reviewed	FERM1_HUMAN	Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1)	FERMT1 C20orf42 KIND1 URP1	Homo sapiens (Human)	677	FUNCTION: Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}.		basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; establishment of epithelial cell polarity [GO:0090162]; integrin-mediated signaling pathway [GO:0007229]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of gene expression [GO:0010629]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of timing of anagen [GO:0051886]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of integrin activation [GO:0033625]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]	cell junction [GO:0030054]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; ruffle membrane [GO:0032587]	actin filament binding [GO:0051015]; integrin binding [GO:0005178]	cell junction [GO:0030054]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; ruffle membrane [GO:0032587]; actin filament binding [GO:0051015]; integrin binding [GO:0005178]; basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; establishment of epithelial cell polarity [GO:0090162]; integrin-mediated signaling pathway [GO:0007229]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of gene expression [GO:0010629]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of timing of anagen [GO:0051886]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of integrin activation [GO:0033625]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles.
Q9BQP7	reviewed	MGME1_HUMAN	Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-)	MGME1 C20orf72 DDK1	Homo sapiens (Human)	344	FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. {ECO:0000255|HAMAP-Rule:MF_03030, ECO:0000269|PubMed:23313956, ECO:0000269|PubMed:23358826}.	MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted. {ECO:0000255|HAMAP-Rule:MF_03030}.	mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; mitochondrial genome maintenance [GO:0000002]	mitochondrion [GO:0005739]	single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]; single-stranded DNA exodeoxyribonuclease activity [GO:0008297]	mitochondrion [GO:0005739]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]; single-stranded DNA exodeoxyribonuclease activity [GO:0008297]; mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; mitochondrial genome maintenance [GO:0000002]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03030, ECO:0000269|PubMed:23313956, ECO:0000269|PubMed:23358826}.
Q9BQQ3	reviewed	GORS1_HUMAN	Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65)	GORASP1 GOLPH5 GRASP65	Homo sapiens (Human)	440	FUNCTION: Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}.		establishment of protein localization to plasma membrane [GO:0061951]; Golgi organization [GO:0007030]; negative regulation of dendrite morphogenesis [GO:0050774]; protein transport [GO:0015031]	cis-Golgi network [GO:0005801]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	metal ion binding [GO:0046872]	cis-Golgi network [GO:0005801]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; metal ion binding [GO:0046872]; establishment of protein localization to plasma membrane [GO:0061951]; Golgi organization [GO:0007030]; negative regulation of dendrite morphogenesis [GO:0050774]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:11781572}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:11781572}.
Q9BQS2	reviewed	SYT15_HUMAN	Synaptotagmin-15 (Chr10Syt) (Synaptotagmin XV) (SytXV)	SYT15	Homo sapiens (Human)	421	FUNCTION: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. {ECO:0000250}.		calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]	exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]	exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]; calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Q9BQS7	reviewed	HEPH_HUMAN	Hephaestin (EC 1.-.-.-)	HEPH KIAA0698 UNQ2562/PRO6242	Homo sapiens (Human)	1158	FUNCTION: May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.		copper ion transport [GO:0006825]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]	basolateral plasma membrane [GO:0016323]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	copper ion binding [GO:0005507]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; oxidoreductase activity [GO:0016491]	basolateral plasma membrane [GO:0016323]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; copper ion binding [GO:0005507]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; oxidoreductase activity [GO:0016491]; copper ion transport [GO:0006825]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9BQS8	reviewed	FYCO1_HUMAN	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)	FYCO1 ZFYVE7	Homo sapiens (Human)	1478	FUNCTION: May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}.		plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of autophagosome maturation [GO:1901098]	autophagosome [GO:0005776]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]	metal ion binding [GO:0046872]	autophagosome [GO:0005776]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; metal ion binding [GO:0046872]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of autophagosome maturation [GO:1901098]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.
Q9BQT8	reviewed	ODC_HUMAN	Mitochondrial 2-oxodicarboxylate carrier (ODC) (Mitochondrial 2-oxoadipate carrier) (Solute carrier family 25 member 21)	SLC25A21 ODC	Homo sapiens (Human)	299	FUNCTION: Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism (PubMed:11083877). Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate (PubMed:11083877). Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle (Probable). {ECO:0000269|PubMed:11083877, ECO:0000305|PubMed:11083877, ECO:0000305|PubMed:29517768}.		lipid transport [GO:0006869]; lysine catabolic process [GO:0006554]; mitochondrial alpha-ketoglutarate transmembrane transport [GO:1990550]	mitochondrial inner membrane [GO:0005743]	alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; antiporter activity [GO:0015297]	mitochondrial inner membrane [GO:0005743]; alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; antiporter activity [GO:0015297]; lipid transport [GO:0006869]; lysine catabolic process [GO:0006554]; mitochondrial alpha-ketoglutarate transmembrane transport [GO:1990550]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
Q9BQT9	reviewed	CSTN3_HUMAN	Calsyntenin-3 (Alcadein-beta) (Alc-beta)	CLSTN3 CS3 KIAA0726	Homo sapiens (Human)	956	FUNCTION: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (PubMed:25352602). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with both neurexin-alpha and neurexin-beta proteins at the presynaptic membrane (PubMed:25352602). Regulates the balance between excitatory and inhibitory synapses by inhibiting formation of excitatory parallel-fiber synapses and promoting formation of inhibitory synapses in the same neuron (By similarity). May also be involved in ascorbate (vitamin C) uptake via its interaction with SLC23A2/SVCT2 (PubMed:34673103). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (PubMed:12972431) (Probable). {ECO:0000250|UniProtKB:Q99JH7, ECO:0000269|PubMed:25352602, ECO:0000269|PubMed:34673103, ECO:0000305|PubMed:12972431}.; FUNCTION: [Isoform CLSTN3beta]: Adipose-specific isoform that plays a key role in adaptive thermogenesis. Facilitates the efficient use of stored triglyceride by promoting multilocular morphology of thermogenic adipocytes: acts by inhibiting the activity of CIDEA and CIDEC on lipid droplets, thereby preventing lipid droplet fusion and facilitating lipid utilization. May also participate in adaptive thermogenesis by promoting sympathetic innervation of thermogenic adipose tissue: acts by driving secretion of neurotrophic factor S100B from brown adipocytes, stimulating neurite outgrowth from sympathetic neurons. {ECO:0000250|UniProtKB:Q99JH7}.		adaptive thermogenesis [GO:1990845]; cold-induced thermogenesis [GO:0106106]; excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inhibitory synapse assembly [GO:1904862]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of excitatory synapse assembly [GO:1904890]; negative regulation of lipid droplet fusion [GO:0160078]; negative regulation of lipid storage [GO:0010888]; positive regulation of inhibitory synapse assembly [GO:1905704]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; protein secretion [GO:0009306]; regulation of cell growth [GO:0001558]; regulation of excitatory synapse assembly [GO:1904889]; regulation of presynapse assembly [GO:1905606]; regulation of synapse assembly [GO:0051963]; sympathetic neuron projection extension [GO:0097490]; synapse assembly [GO:0007416]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]	cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; organelle membrane contact site [GO:0044232]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]	amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; cell-cell adhesion mediator activity [GO:0098632]; enzyme inhibitor activity [GO:0004857]; kinesin binding [GO:0019894]; neurexin family protein binding [GO:0042043]; X11-like protein binding [GO:0042988]	cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; organelle membrane contact site [GO:0044232]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; cell-cell adhesion mediator activity [GO:0098632]; enzyme inhibitor activity [GO:0004857]; kinesin binding [GO:0019894]; neurexin family protein binding [GO:0042043]; X11-like protein binding [GO:0042988]; adaptive thermogenesis [GO:1990845]; cold-induced thermogenesis [GO:0106106]; excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inhibitory synapse assembly [GO:1904862]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of excitatory synapse assembly [GO:1904890]; negative regulation of lipid droplet fusion [GO:0160078]; negative regulation of lipid storage [GO:0010888]; positive regulation of inhibitory synapse assembly [GO:1905704]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; protein secretion [GO:0009306]; regulation of cell growth [GO:0001558]; regulation of excitatory synapse assembly [GO:1904889]; regulation of presynapse assembly [GO:1905606]; regulation of synapse assembly [GO:0051963]; sympathetic neuron projection extension [GO:0097490]; synapse assembly [GO:0007416]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q99JH7}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q99JH7}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q99JH7}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99JH7}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. {ECO:0000250|UniProtKB:Q99JH7}.; SUBCELLULAR LOCATION: [Isoform CLSTN3beta]: Lipid droplet {ECO:0000250|UniProtKB:Q99JH7}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q99JH7}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to endoplasmic reticulum-lipid droplet contact sites through the partitioning of its N-terminal hydrophobic hairpins onto lipid droplets while its C-terminal transmembrane domain remains anchored in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q99JH7}.
Q9BQW3	reviewed	COE4_HUMAN	Transcription factor COE4 (Early B-cell factor 4) (EBF-4) (Olf-1/EBF-like 4) (O/E-4) (OE-4)	EBF4 COE4 KIAA1442	Homo sapiens (Human)	602	FUNCTION: Transcription factor (PubMed:35939714). Binds to specific sequence motif 5'-CCCNNG[GA]G-3' in regulatory elements of putative target immunoregulatory genes such as NKG7, GZMA, and TBX21 (PubMed:35939714). Positively modulates transcription of NKG7 (PubMed:35939714). May play a role in regulating FAS/CD95-mediated apoptosis in cytotoxic NK cells and T-cells, probably downstream of interleukin IL2 signaling (PubMed:35939714). {ECO:0000269|PubMed:35939714}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell apoptotic process [GO:0070231]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell apoptotic process [GO:0070231]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35939714}.
Q9BQY4	reviewed	RHXF2_HUMAN	Rhox homeobox family member 2 (Paired-like homeobox protein PEPP-2) (Testis homeobox gene 1)	RHOXF2 PEPP2 THG1	Homo sapiens (Human)	288	FUNCTION: Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis. {ECO:0000269|PubMed:28171660}.		positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q9BR01	reviewed	ST4A1_HUMAN	Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (hBR-STL) (hBR-STL-1) (Nervous system sulfotransferase) (NST)	SULT4A1 SULTX3	Homo sapiens (Human)	284	FUNCTION: Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS. {ECO:0000269|PubMed:17425406}.		dendrite arborization [GO:0140059]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	identical protein binding [GO:0042802]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; identical protein binding [GO:0042802]; sulfotransferase activity [GO:0008146]; dendrite arborization [GO:0140059]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9BR39	reviewed	JPH2_HUMAN	Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)]	JPH2 JP2	Homo sapiens (Human)	696	FUNCTION: [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}.		calcium ion homeostasis [GO:0055074]; calcium ion transport into cytosol [GO:0060402]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle tissue development [GO:0055024]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]	endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; Z disc [GO:0030018]	DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; phosphatidylserine binding [GO:0001786]	endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; Z disc [GO:0030018]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; phosphatidylserine binding [GO:0001786]; calcium ion homeostasis [GO:0055074]; calcium ion transport into cytosol [GO:0060402]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle tissue development [GO:0055024]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]	SUBCELLULAR LOCATION: [Junctophilin-2]: Cell membrane {ECO:0000250|UniProtKB:Q9ET78}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9ET78}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ET78}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9ET78}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ET78}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9ET78}. Note=The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands. {ECO:0000250|UniProtKB:Q9ET78}.; SUBCELLULAR LOCATION: [Junctophilin-2 N-terminal fragment]: Nucleus {ECO:0000269|PubMed:30409805}. Note=Accumulates in the nucleus of stressed hearts. {ECO:0000250|UniProtKB:Q9ET78}.
Q9BR76	reviewed	COR1B_HUMAN	Coronin-1B (Coronin-2)	CORO1B	Homo sapiens (Human)	489	FUNCTION: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}.		actin cytoskeleton organization [GO:0030036]; actin filament branching [GO:0090135]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; endothelial cell chemotaxis [GO:0035767]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; positive regulation of lamellipodium morphogenesis [GO:2000394]; protein localization to cell leading edge [GO:1902463]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; wound healing [GO:0042060]	actin filament [GO:0005884]; cell leading edge [GO:0031252]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]	actin filament [GO:0005884]; cell leading edge [GO:0031252]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; actin cytoskeleton organization [GO:0030036]; actin filament branching [GO:0090135]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; endothelial cell chemotaxis [GO:0035767]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; positive regulation of lamellipodium morphogenesis [GO:2000394]; protein localization to cell leading edge [GO:1902463]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16027158}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:16027158}. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers. {ECO:0000269|PubMed:16027158}.
Q9BRA0	reviewed	LSMD1_HUMAN	N-alpha-acetyltransferase 38, NatC auxiliary subunit (LSM domain-containing protein 1) (Phosphonoformate immuno-associated protein 2)	NAA38 LSMD1 MAK31 PFAAP2	Homo sapiens (Human)	125	FUNCTION: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. {ECO:0000269|PubMed:19398576}.		negative regulation of apoptotic process [GO:0043066]	cytoplasm [GO:0005737]; NatC complex [GO:0031417]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; NatC complex [GO:0031417]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; negative regulation of apoptotic process [GO:0043066]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19398576}. Nucleus {ECO:0000269|PubMed:19398576}.
Q9BRA2	reviewed	TXD17_HUMAN	Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5)	TXNDC17 TXNL5	Homo sapiens (Human)	123	FUNCTION: Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. {ECO:0000269|PubMed:14607843, ECO:0000269|PubMed:14607844}.		tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	peroxidase activity [GO:0004601]; protein-disulfide reductase (NAD(P)) activity [GO:0047134]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxidase activity [GO:0004601]; protein-disulfide reductase (NAD(P)) activity [GO:0047134]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14607844}.
Q9BRB3	reviewed	PIGQ_HUMAN	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (N-acetylglucosamyl transferase component GPI1) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q)	PIGQ GPI1	Homo sapiens (Human)	760	FUNCTION: Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. {ECO:0000269|PubMed:16162815, ECO:0000269|PubMed:9463366}.		carbohydrate metabolic process [GO:0005975]; GPI anchor biosynthetic process [GO:0006506]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; carbohydrate metabolic process [GO:0005975]; GPI anchor biosynthetic process [GO:0006506]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9BRC7	reviewed	PLCD4_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (hPLCD4) (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-4) (Phospholipase C-delta-4) (PLC-delta-4)	PLCD4	Homo sapiens (Human)	762	FUNCTION: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269|PubMed:15140260}.; FUNCTION: [Isoform 2]: Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3. {ECO:0000269|PubMed:30194280}.	MISCELLANEOUS: [Isoform 1]: Acceptor splice site between exons 4 and 5 is non-canonical but conserved through species for that particular gene.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	acrosome reaction [GO:0007340]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phospholipase C activity [GO:0004435]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phospholipase C activity [GO:0004435]; acrosome reaction [GO:0007340]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:15140260}. Endoplasmic reticulum {ECO:0000250}. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
Q9BRD0	reviewed	BUD13_HUMAN	BUD13 homolog	BUD13	Homo sapiens (Human)	619	FUNCTION: Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.		mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RES complex [GO:0070274]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RES complex [GO:0070274]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316}.
Q9BRF8	reviewed	CPPED_HUMAN	Serine/threonine-protein phosphatase CPPED1 (EC 3.1.3.16) (Calcineurin-like phosphoesterase domain-containing protein 1) (Complete S-transactivated protein 1)	CPPED1 CSTP1	Homo sapiens (Human)	314	FUNCTION: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. {ECO:0000269|PubMed:23799035, ECO:0000269|PubMed:23939394}.			azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23799035}.
Q9BRG1	reviewed	VPS25_HUMAN	Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25)	VPS25 DERP9 EAP20	Homo sapiens (Human)	176	FUNCTION: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. {ECO:0000269|PubMed:18723511}.		macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]	SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane. Nucleus, nucleoplasm. Note=Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6.
Q9BRG2	reviewed	SH23A_HUMAN	SH2 domain-containing protein 3A (Novel SH2-containing protein 1)	SH2D3A NSP1 UNQ175/PRO201	Homo sapiens (Human)	576	FUNCTION: May play a role in JNK activation.		JNK cascade [GO:0007254]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; small GTPase mediated signal transduction [GO:0007264]		guanyl-nucleotide exchange factor activity [GO:0005085]; phosphotyrosine residue binding [GO:0001784]	guanyl-nucleotide exchange factor activity [GO:0005085]; phosphotyrosine residue binding [GO:0001784]; JNK cascade [GO:0007254]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; small GTPase mediated signal transduction [GO:0007264]	
Q9BRI3	reviewed	ZNT2_HUMAN	Proton-coupled zinc antiporter SLC30A2 (Solute carrier family 30 member 2) (Zinc transporter 2) (ZnT-2)	SLC30A2 ZNT2	Homo sapiens (Human)	372	FUNCTION: [Isoform 1]: Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:21289295, PubMed:25808614, PubMed:25657003, PubMed:30893306, PubMed:17065149, PubMed:22733820). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (PubMed:19496757). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (PubMed:25808614). {ECO:0000269|PubMed:17065149, ECO:0000269|PubMed:19496757, ECO:0000269|PubMed:21289295, ECO:0000269|PubMed:22733820, ECO:0000269|PubMed:25657003, ECO:0000269|PubMed:25808614, ECO:0000269|PubMed:30893306}.; FUNCTION: [Isoform 2]: Electroneutral proton-coupled antiporter mediating the efflux of zinc ions through the plasma membrane. {ECO:0000269|PubMed:19496757}.		intracellular zinc ion homeostasis [GO:0006882]; positive regulation of sequestering of zinc ion [GO:0061090]; regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043]; zinc export across plasma membrane [GO:0140882]; zinc ion import into lysosome [GO:0140916]; zinc ion import into mitochondrion [GO:0140917]; zinc ion import into organelle [GO:0062111]; zinc ion import into secretory vesicle [GO:0140914]; zinc ion import into zymogen granule [GO:0140915]; zinc ion transmembrane transport [GO:0071577]	cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]; secretory vesicle [GO:0099503]; transport vesicle membrane [GO:0030658]; zymogen granule membrane [GO:0042589]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826]	cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]; secretory vesicle [GO:0099503]; transport vesicle membrane [GO:0030658]; zymogen granule membrane [GO:0042589]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826]; intracellular zinc ion homeostasis [GO:0006882]; positive regulation of sequestering of zinc ion [GO:0061090]; regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043]; zinc export across plasma membrane [GO:0140882]; zinc ion import into lysosome [GO:0140916]; zinc ion import into mitochondrion [GO:0140917]; zinc ion import into organelle [GO:0062111]; zinc ion import into secretory vesicle [GO:0140914]; zinc ion import into zymogen granule [GO:0140915]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:19496757}; Multi-pass membrane protein {ECO:0000255}. Zymogen granule membrane {ECO:0000250|UniProtKB:Q2HJ10}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:19496757, ECO:0000269|PubMed:25808614}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:25808614, ECO:0000269|PubMed:30893306}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:21289295}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to lysosomes is induced by TNF-alpha. {ECO:0000269|PubMed:25808614}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:19496757}; Multi-pass membrane protein {ECO:0000255}.
Q9BRJ7	reviewed	TIRR_HUMAN	Tudor-interacting repair regulator protein (NUDT16-like protein 1) (Protein syndesmos)	NUDT16L1 SDOS TIRR	Homo sapiens (Human)	211	FUNCTION: Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299). {ECO:0000269|PubMed:18820299, ECO:0000269|PubMed:28241136}.		negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]	nucleus [GO:0005634]	RNA binding [GO:0003723]; snoRNA binding [GO:0030515]	nucleus [GO:0005634]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28241136}.
Q9BRJ9	reviewed	MESP1_HUMAN	Mesoderm posterior protein 1 (Class C basic helix-loop-helix protein 5) (bHLHc5)	MESP1 BHLHC5	Homo sapiens (Human)	268	FUNCTION: Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity). {ECO:0000250}.	MISCELLANEOUS: The N- and C-terminal domains are separated by a 2-repeat G-Q region.	cardiac atrium formation [GO:0003210]; cardiac cell fate determination [GO:0060913]; cardiac muscle cell differentiation [GO:0055007]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cardiac ventricle formation [GO:0003211]; cardioblast anterior-lateral migration [GO:0003259]; cardioblast migration to the midline involved in heart field formation [GO:0060975]; embryonic heart tube morphogenesis [GO:0003143]; endothelial cell differentiation [GO:0045446]; gastrulation [GO:0007369]; gene expression [GO:0010467]; growth involved in heart morphogenesis [GO:0003241]; heart looping [GO:0001947]; heart morphogenesis [GO:0003007]; lateral mesoderm development [GO:0048368]; mesoderm formation [GO:0001707]; mesodermal cell migration [GO:0008078]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endodermal cell fate specification [GO:0042664]; negative regulation of mesodermal cell fate specification [GO:0042662]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [GO:0090082]; positive regulation of hepatocyte differentiation [GO:0070368]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of Notch signaling pathway involved in heart induction [GO:0035481]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; secondary heart field specification [GO:0003139]; signal transduction involved in regulation of gene expression [GO:0023019]; sinoatrial node cell differentiation [GO:0060921]; sinus venosus morphogenesis [GO:0003236]; somite rostral/caudal axis specification [GO:0032525]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; cardiac atrium formation [GO:0003210]; cardiac cell fate determination [GO:0060913]; cardiac muscle cell differentiation [GO:0055007]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cardiac ventricle formation [GO:0003211]; cardioblast anterior-lateral migration [GO:0003259]; cardioblast migration to the midline involved in heart field formation [GO:0060975]; embryonic heart tube morphogenesis [GO:0003143]; endothelial cell differentiation [GO:0045446]; gastrulation [GO:0007369]; gene expression [GO:0010467]; growth involved in heart morphogenesis [GO:0003241]; heart looping [GO:0001947]; heart morphogenesis [GO:0003007]; lateral mesoderm development [GO:0048368]; mesoderm formation [GO:0001707]; mesodermal cell migration [GO:0008078]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endodermal cell fate specification [GO:0042664]; negative regulation of mesodermal cell fate specification [GO:0042662]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [GO:0090082]; positive regulation of hepatocyte differentiation [GO:0070368]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of Notch signaling pathway involved in heart induction [GO:0035481]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; secondary heart field specification [GO:0003139]; signal transduction involved in regulation of gene expression [GO:0023019]; sinoatrial node cell differentiation [GO:0060921]; sinus venosus morphogenesis [GO:0003236]; somite rostral/caudal axis specification [GO:0032525]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BRK0	reviewed	REEP2_HUMAN	Receptor expression-enhancing protein 2	REEP2 C5orf19 SGC32445	Homo sapiens (Human)	252	FUNCTION: Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:24388663}.		endoplasmic reticulum tubular network organization [GO:0071786]; protein transport into membrane raft [GO:0032596]; regulation of intracellular transport [GO:0032386]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]	cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; plasma membrane [GO:0005886]	microtubule binding [GO:0008017]; taste receptor binding [GO:0031883]	cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; plasma membrane [GO:0005886]; microtubule binding [GO:0008017]; taste receptor binding [GO:0031883]; endoplasmic reticulum tubular network organization [GO:0071786]; protein transport into membrane raft [GO:0032596]; regulation of intracellular transport [GO:0032386]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9BRK3	reviewed	MXRA8_HUMAN	Matrix remodeling-associated protein 8 (Limitrin)	MXRA8	Homo sapiens (Human)	442	FUNCTION: Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:22492581, PubMed:23386276). Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed:23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed:23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed:23386276). May play a role in the maturation and maintenance of the blood-brain barrier (By similarity). {ECO:0000250|UniProtKB:Q9DBV4, ECO:0000269|PubMed:22492581, ECO:0000269|PubMed:23386276}.; FUNCTION: (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses. {ECO:0000269|PubMed:29769725}.		cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; establishment of glial blood-brain barrier [GO:0060857]	bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]		bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; establishment of glial blood-brain barrier [GO:0060857]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23386276}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9DBV4}. Cytoplasm {ECO:0000250|UniProtKB:Q9DBV4}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q9DBV4}. Nucleus {ECO:0000269|PubMed:23386276}. Note=Primarily localizes to the cell membrane (PubMed:23386276). Detected in the cilium of primary chondrocytes (By similarity). Highly expressed at areas of cell-cell contact and may localize to tight junctions (By similarity). Also found in the nucleus where it is detected in the soluble (as opposed to chromatin-bound) fraction (PubMed:23386276). {ECO:0000250|UniProtKB:Q9DBV4, ECO:0000269|PubMed:23386276}.
Q9BRK4	reviewed	LZTS2_HUMAN	Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)	LZTS2 KIAA1813 LAPSER1	Homo sapiens (Human)	669	FUNCTION: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}.		fibroblast proliferation [GO:0048144]; microtubule severing [GO:0051013]; mitotic cytokinesis [GO:0000281]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of protein localization to nucleus [GO:1900181]; nuclear export [GO:0051168]; primary ureteric bud growth [GO:0060682]; spindle midzone assembly [GO:0051255]; ureter morphogenesis [GO:0072197]; Wnt signaling pathway [GO:0016055]	centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; midbody [GO:0030496]; plasma membrane [GO:0005886]; vesicle [GO:0031982]		centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; midbody [GO:0030496]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; fibroblast proliferation [GO:0048144]; microtubule severing [GO:0051013]; mitotic cytokinesis [GO:0000281]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of protein localization to nucleus [GO:1900181]; nuclear export [GO:0051168]; primary ureteric bud growth [GO:0060682]; spindle midzone assembly [GO:0051255]; ureter morphogenesis [GO:0072197]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
Q9BRK5	reviewed	CAB45_HUMAN	45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4)	SDF4 CAB45 PSEC0034	Homo sapiens (Human)	362	FUNCTION: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.		calcium-ion regulated exocytosis [GO:0017156]; cerebellum development [GO:0021549]; fat cell differentiation [GO:0045444]; maintenance of synapse structure [GO:0099558]; response to ethanol [GO:0045471]; UV protection [GO:0009650]; zymogen granule exocytosis [GO:0070625]	bleb [GO:0032059]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; late endosome [GO:0005770]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]	bleb [GO:0032059]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; late endosome [GO:0005770]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; calcium-ion regulated exocytosis [GO:0017156]; cerebellum development [GO:0021549]; fat cell differentiation [GO:0045444]; maintenance of synapse structure [GO:0099558]; response to ethanol [GO:0045471]; UV protection [GO:0009650]; zymogen granule exocytosis [GO:0070625]	SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus lumen {ECO:0000250|UniProtKB:Q61112}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:17442889}. Cell membrane {ECO:0000269|PubMed:17442889}. Cell projection, bleb. Note=Isoform 5 colocalizes with STX3 and STXBP1 isoform 2 at the plasma membrane and cell surface blebs. {ECO:0000269|PubMed:17442889}.
Q9BRL6	reviewed	SRSF8_HUMAN	Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)	SRSF8 SFRS2B SRP46	Homo sapiens (Human)	282	FUNCTION: Involved in pre-mRNA alternative splicing. {ECO:0000269|PubMed:9671500}.		mRNA splicing, via spliceosome [GO:0000398]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9671500}.
Q9BRL7	reviewed	SC22C_HUMAN	Vesicle-trafficking protein SEC22c (SEC22 vesicle-trafficking protein homolog C) (SEC22 vesicle-trafficking protein-like 3)	SEC22C SEC22L3 UNQ459/PRO784	Homo sapiens (Human)	303	FUNCTION: May be involved in vesicle transport between the ER and the Golgi complex. {ECO:0000269|PubMed:9501016}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9501016}; Multi-pass membrane protein {ECO:0000269|PubMed:9501016}.
Q9BRP0	reviewed	OVOL2_HUMAN	Transcription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339)	OVOL2 ZNF339	Homo sapiens (Human)	275	FUNCTION: Zinc-finger transcription repressor factor (PubMed:19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410). Important for the correct development of primordial germ cells in embryos (By similarity). Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (By similarity). {ECO:0000250|UniProtKB:Q8CIV7, ECO:0000269|PubMed:19700410}.		angiogenesis [GO:0001525]; cell population proliferation [GO:0008283]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dorsal/ventral pattern formation [GO:0009953]; embryonic digestive tract morphogenesis [GO:0048557]; endocardium formation [GO:0060214]; epidermal cell differentiation [GO:0009913]; heart looping [GO:0001947]; heart trabecula formation [GO:0060347]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of gene expression [GO:0010629]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by competitive promoter binding [GO:0010944]; neural crest cell migration [GO:0001755]; neural fold formation [GO:0001842]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; regulation of cell cycle [GO:0051726]; regulation of keratinocyte proliferation [GO:0010837]; regulation of SMAD protein signal transduction [GO:0060390]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; angiogenesis [GO:0001525]; cell population proliferation [GO:0008283]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dorsal/ventral pattern formation [GO:0009953]; embryonic digestive tract morphogenesis [GO:0048557]; endocardium formation [GO:0060214]; epidermal cell differentiation [GO:0009913]; heart looping [GO:0001947]; heart trabecula formation [GO:0060347]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of gene expression [GO:0010629]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by competitive promoter binding [GO:0010944]; neural crest cell migration [GO:0001755]; neural fold formation [GO:0001842]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; regulation of cell cycle [GO:0051726]; regulation of keratinocyte proliferation [GO:0010837]; regulation of SMAD protein signal transduction [GO:0060390]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8CIV7}.
Q9BRP8	reviewed	PYM1_HUMAN	Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog)	PYM1 PYM WIBG	Homo sapiens (Human)	204	FUNCTION: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269|PubMed:18026120, ECO:0000269|PubMed:19410547}.		exon-exon junction complex disassembly [GO:1903259]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; exon-exon junction complex disassembly [GO:1903259]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14968132, ECO:0000269|PubMed:18026120}. Nucleus, nucleolus {ECO:0000269|PubMed:14968132}. Nucleus, nucleoplasm {ECO:0000269|PubMed:14968132}. Note=Shuttles between the nucleus and the cytoplasm (PubMed:14968132). Nuclear export is mediated by XPO1/CRM1 (PubMed:14968132). {ECO:0000269|PubMed:14968132}.
Q9BRQ0	reviewed	PYGO2_HUMAN	Pygopus homolog 2	PYGO2 PP7910	Homo sapiens (Human)	406	FUNCTION: Involved in signal transduction through the Wnt pathway.		brain development [GO:0007420]; canonical Wnt signaling pathway [GO:0060070]; developmental growth [GO:0048589]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; mammary gland development [GO:0030879]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; roof of mouth development [GO:0060021]; spermatid nucleus differentiation [GO:0007289]	beta-catenin-TCF complex [GO:1990907]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; histone acetyltransferase regulator activity [GO:0035034]; histone binding [GO:0042393]; metal ion binding [GO:0046872]	beta-catenin-TCF complex [GO:1990907]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; histone acetyltransferase regulator activity [GO:0035034]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; brain development [GO:0007420]; canonical Wnt signaling pathway [GO:0060070]; developmental growth [GO:0048589]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; mammary gland development [GO:0030879]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; roof of mouth development [GO:0060021]; spermatid nucleus differentiation [GO:0007289]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BRQ3	reviewed	NUD22_HUMAN	Uridine diphosphate glucose pyrophosphatase NUDT22 (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 22) (Nudix motif 22)	NUDT22 PP11246	Homo sapiens (Human)	303	FUNCTION: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose. {ECO:0000269|PubMed:29413322}.			nucleoplasm [GO:0005654]	GDP-mannose hydrolase activity [GO:0052751]; metal ion binding [GO:0046872]; UDP-sugar diphosphatase activity [GO:0008768]	nucleoplasm [GO:0005654]; GDP-mannose hydrolase activity [GO:0052751]; metal ion binding [GO:0046872]; UDP-sugar diphosphatase activity [GO:0008768]	
Q9BRQ6	reviewed	MIC25_HUMAN	MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6)	CHCHD6 CHCM1 MIC25	Homo sapiens (Human)	235	FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22228767}.		cristae formation [GO:0042407]; DNA damage response [GO:0006974]; inner mitochondrial membrane organization [GO:0007007]	cytosol [GO:0005829]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]		cytosol [GO:0005829]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]; cristae formation [GO:0042407]; DNA damage response [GO:0006974]; inner mitochondrial membrane organization [GO:0007007]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:22228767}; Lipid-anchor {ECO:0000305|PubMed:22228767}. Mitochondrion {ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:25997101}.
Q9BRQ8	reviewed	FSP1_HUMAN	Ferroptosis suppressor protein 1 (FSP1) (EC 1.6.5.-) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (AMID) (p53-responsive gene 3 protein)	AIFM2 AMID PRG3	Homo sapiens (Human)	373	FUNCTION: A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis (PubMed:31634899, PubMed:31634900, PubMed:35922516). At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis (PubMed:31634899, PubMed:31634900). Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis (PubMed:31634899, PubMed:31634900). This anti-ferroptotic function is independent of cellular glutathione levels (PubMed:31634899, PubMed:31634900). Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms (PubMed:35922516). Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis (PubMed:35922516). May play a role in mitochondrial stress signaling (PubMed:26689472). Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death (PubMed:26689472). Capable of DNA binding in a non-sequence specific way (PubMed:15958387). {ECO:0000269|PubMed:15958387, ECO:0000269|PubMed:26689472, ECO:0000269|PubMed:31634899, ECO:0000269|PubMed:31634900, ECO:0000269|PubMed:35922516}.		apoptotic mitochondrial changes [GO:0008637]; cellular detoxification [GO:1990748]; negative regulation of ferroptosis [GO:0110076]; positive regulation of apoptotic process [GO:0043065]; regulation of cellular response to oxidative stress [GO:1900407]; ubiquinone metabolic process [GO:0006743]; vitamin K metabolic process [GO:0042373]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; lipid droplet [GO:0005811]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]; electron-transferring-flavoprotein dehydrogenase activity [GO:0004174]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; lipid droplet [GO:0005811]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; electron-transferring-flavoprotein dehydrogenase activity [GO:0004174]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; apoptotic mitochondrial changes [GO:0008637]; cellular detoxification [GO:1990748]; negative regulation of ferroptosis [GO:0110076]; positive regulation of apoptotic process [GO:0043065]; regulation of cellular response to oxidative stress [GO:1900407]; ubiquinone metabolic process [GO:0006743]; vitamin K metabolic process [GO:0042373]	SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:31634900}. Cell membrane {ECO:0000269|PubMed:31634900}; Lipid-anchor {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:11980907, ECO:0000269|PubMed:12135761, ECO:0000269|PubMed:26689472}. Mitochondrion membrane {ECO:0000269|PubMed:11980907, ECO:0000269|PubMed:26689472}. Nucleus {ECO:0000269|PubMed:26689472}.
Q9BRR0	reviewed	ZKSC3_HUMAN	Zinc finger protein with KRAB and SCAN domains 3 (Zinc finger and SCAN domain-containing protein 13) (Zinc finger protein 306) (Zinc finger protein 309) (Zinc finger protein 47 homolog) (Zf47) (Zfp-47)	ZKSCAN3 ZFP47 ZNF306 ZNF309 ZSCAN13	Homo sapiens (Human)	538	FUNCTION: Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas. {ECO:0000269|PubMed:18940803, ECO:0000269|PubMed:21057542, ECO:0000269|PubMed:22531714, ECO:0000269|PubMed:23434374}.		autophagy [GO:0006914]; lysosome organization [GO:0007040]; negative regulation of autophagy [GO:0010507]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; autophagy [GO:0006914]; lysosome organization [GO:0007040]; negative regulation of autophagy [GO:0010507]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function.
Q9BRR3	reviewed	PGAP4_HUMAN	Post-GPI attachment to proteins factor 4 (Post-GPI attachment to proteins GalNAc transferase 4) (Transmembrane protein 246)	PGAP4 C9orf125 TMEM246	Homo sapiens (Human)	403	FUNCTION: Golgi-resident glycosylphosphatidylinositol (GPI)-N-acetylgalactosamine transferase involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins (PubMed:29374258). Required for the initial step of GPI-GalNAc biosynthesis, transfers GalNAc to GPI in the Golgi after fatty acid remodeling by PGAP2 (PubMed:29374258). {ECO:0000269|PubMed:29374258}.		GPI anchor biosynthetic process [GO:0006506]	Golgi membrane [GO:0000139]	glycosyltransferase activity [GO:0016757]	Golgi membrane [GO:0000139]; glycosyltransferase activity [GO:0016757]; GPI anchor biosynthetic process [GO:0006506]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:29374258}; Multi-pass membrane protein {ECO:0000269|PubMed:29374258}.
Q9BRR6	reviewed	ADPGK_HUMAN	ADP-dependent glucokinase (ADP-GK) (ADPGK) (EC 2.7.1.147) (RbBP-35)	ADPGK PSEC0260	Homo sapiens (Human)	497	FUNCTION: Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity). {ECO:0000250}.		glucose metabolic process [GO:0006006]; glycolytic process through glucose-6-phosphate [GO:0061620]; phosphorylation [GO:0016310]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020]	ADP-specific glucokinase activity [GO:0043843]; metal ion binding [GO:0046872]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020]; ADP-specific glucokinase activity [GO:0043843]; metal ion binding [GO:0046872]; glucose metabolic process [GO:0006006]; glycolytic process through glucose-6-phosphate [GO:0061620]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BRR9	reviewed	RHG09_HUMAN	Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9)	ARHGAP9	Homo sapiens (Human)	750	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:11396949}.		regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; secretory granule lumen [GO:0034774]	GTPase activator activity [GO:0005096]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; secretory granule lumen [GO:0034774]; GTPase activator activity [GO:0005096]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	
Q9BRS2	reviewed	RIOK1_HUMAN	Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1)	RIOK1 RIO1	Homo sapiens (Human)	568	FUNCTION: Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). {ECO:0000250|UniProtKB:G0S3J5, ECO:0000250|UniProtKB:Q12196, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:22072790}.		maturation of SSU-rRNA [GO:0030490]; phosphorylation [GO:0016310]; positive regulation of rRNA processing [GO:2000234]; ribosomal small subunit biogenesis [GO:0042274]	cytosol [GO:0005829]; methyltransferase complex [GO:0034708]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]	ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; methyltransferase complex [GO:0034708]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; maturation of SSU-rRNA [GO:0030490]; phosphorylation [GO:0016310]; positive regulation of rRNA processing [GO:2000234]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21081503}.
Q9BRS8	reviewed	LARP6_HUMAN	La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6)	LARP6	Homo sapiens (Human)	491	FUNCTION: Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}.		positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; RNA processing [GO:0006396]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]	mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; myosin binding [GO:0017022]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; myosin binding [GO:0017022]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17383118}. Nucleus {ECO:0000269|PubMed:17383118}. Note=Shuttles between the nucleus and the cytoplasm.
Q9BRT2	reviewed	UQCC2_HUMAN	Ubiquinol-cytochrome c reductase complex assembly factor 2 (Breast cancer-associated protein SGA-81M) (Mitochondrial nucleoid factor 1) (Mitochondrial protein M19)	UQCC2 C6orf125 MNF1	Homo sapiens (Human)	126	FUNCTION: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability. {ECO:0000269|PubMed:22363741, ECO:0000269|PubMed:24385928}.		mitochondrial respiratory chain complex III assembly [GO:0034551]; positive regulation of mitochondrial translation [GO:0070131]; regulation of insulin secretion [GO:0050796]; regulation of oxidative phosphorylation [GO:0002082]; regulation of skeletal muscle cell differentiation [GO:2001014]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]		mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; mitochondrial respiratory chain complex III assembly [GO:0034551]; positive regulation of mitochondrial translation [GO:0070131]; regulation of insulin secretion [GO:0050796]; regulation of oxidative phosphorylation [GO:0002082]; regulation of skeletal muscle cell differentiation [GO:2001014]	SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion. Mitochondrion intermembrane space {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}. Note=Predominantly expressed in the mitochondrial inner membrane. {ECO:0000250}.
Q9BRT3	reviewed	MIEN1_HUMAN	Migration and invasion enhancer 1 (HBV X-transactivated gene 4 protein) (HBV XAg-transactivated protein 4) (Protein C35)	MIEN1 C17orf37 RDX12 XTP4	Homo sapiens (Human)	115	FUNCTION: Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process. {ECO:0000269|PubMed:19503095, ECO:0000269|PubMed:21628459}.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell migration [GO:0030335]; positive regulation of filopodium assembly [GO:0051491]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886]		cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell migration [GO:0030335]; positive regulation of filopodium assembly [GO:0051491]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.
Q9BRT8	reviewed	ZNG1A_HUMAN	Zinc-regulated GTPase metalloprotein activator 1A (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 1) (COBW domain-containing protein 1) (NPC-A-6 COBW domain-containing protein 1) (NPC-A-6)	ZNG1A CBWD1	Homo sapiens (Human)	395	FUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1A to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}.		kidney development [GO:0001822]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; kidney development [GO:0001822]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VEH6}.
Q9BRT9	reviewed	SLD5_HUMAN	DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]	GINS4 SLD5	Homo sapiens (Human)	223	FUNCTION: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). {ECO:0000269|PubMed:17417653, ECO:0000269|PubMed:28414293, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}.		DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; inner cell mass cell proliferation [GO:0001833]	CMG complex [GO:0071162]; cytoplasm [GO:0005737]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		CMG complex [GO:0071162]; cytoplasm [GO:0005737]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; inner cell mass cell proliferation [GO:0001833]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Cytoplasm {ECO:0000250|UniProtKB:Q99LZ3}. Note=Associates with chromatin. {ECO:0000305|PubMed:35585232}.
Q9BRU9	reviewed	UTP23_HUMAN	rRNA-processing protein UTP23 homolog	UTP23 C8orf53	Homo sapiens (Human)	249	FUNCTION: Involved in rRNA-processing and ribosome biogenesis. {ECO:0000250}.		endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]	nucleolus [GO:0005730]; small-subunit processome [GO:0032040]	mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]	nucleolus [GO:0005730]; small-subunit processome [GO:0032040]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
Q9BRV3	reviewed	SWET1_HUMAN	Sugar transporter SWEET1 (HsSWEET1) (RAG1-activating protein 1) (Solute carrier family 50 member 1) (Stromal cell protein)	SLC50A1 RAG1AP1 SCP	Homo sapiens (Human)	221	FUNCTION: Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. {ECO:0000269|PubMed:21107422}.		carbohydrate transport [GO:0008643]; hexose transmembrane transport [GO:0008645]	endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	glucoside transmembrane transporter activity [GO:0042947]; sugar transmembrane transporter activity [GO:0051119]	endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; glucoside transmembrane transporter activity [GO:0042947]; sugar transmembrane transporter activity [GO:0051119]; carbohydrate transport [GO:0008643]; hexose transmembrane transport [GO:0008645]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:21107422}; Multi-pass membrane protein {ECO:0000269|PubMed:21107422}. Cell membrane {ECO:0000269|PubMed:21107422}; Multi-pass membrane protein {ECO:0000269|PubMed:21107422}. Note=May also localize to the endoplasmic reticulum. {ECO:0000250}.
Q9BRV8	reviewed	SIKE1_HUMAN	Suppressor of IKBKE 1 (Suppressor of IKK-epsilon)	SIKE1 SIKE	Homo sapiens (Human)	207	FUNCTION: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways. {ECO:0000269|PubMed:16281057}.			cytosol [GO:0005829]	protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16281057}.
Q9BRX2	reviewed	PELO_HUMAN	Protein pelota homolog (hPelota) (Protein Dom34 homolog)	PELO CGI-17	Homo sapiens (Human)	385	FUNCTION: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27543824, PubMed:27863242). In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27543824, PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27543824, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:32006463}.		cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome organization [GO:0051276]; endoderm development [GO:0007492]; inner cell mass cell proliferation [GO:0001833]; mesenchymal to epithelial transition [GO:0060231]; nonfunctional rRNA decay [GO:0070651]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA catabolic process, non-stop decay [GO:0070481]; positive regulation of BMP signaling pathway [GO:0030513]; regulation of translation [GO:0006417]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; RNA surveillance [GO:0071025]; stem cell population maintenance [GO:0019827]	cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; Dom34-Hbs1 complex [GO:1990533]	metal ion binding [GO:0046872]; ribosome binding [GO:0043022]; stalled ribosome sensor activity [GO:0170011]	cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; Dom34-Hbs1 complex [GO:1990533]; metal ion binding [GO:0046872]; ribosome binding [GO:0043022]; stalled ribosome sensor activity [GO:0170011]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome organization [GO:0051276]; endoderm development [GO:0007492]; inner cell mass cell proliferation [GO:0001833]; mesenchymal to epithelial transition [GO:0060231]; nonfunctional rRNA decay [GO:0070651]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA catabolic process, non-stop decay [GO:0070481]; positive regulation of BMP signaling pathway [GO:0030513]; regulation of translation [GO:0006417]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; RNA surveillance [GO:0071025]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:21448132}.
Q9BRX5	reviewed	PSF3_HUMAN	DNA replication complex GINS protein PSF3 (GINS complex subunit 3)	GINS3 PSF3	Homo sapiens (Human)	216	FUNCTION: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). {ECO:0000269|PubMed:17417653, ECO:0000269|PubMed:28414293, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}.		DNA unwinding involved in DNA replication [GO:0006268]; mitotic DNA replication initiation [GO:1902975]	CMG complex [GO:0071162]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		CMG complex [GO:0071162]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA unwinding involved in DNA replication [GO:0006268]; mitotic DNA replication initiation [GO:1902975]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associates with chromatin. {ECO:0000305|PubMed:35585232}.
Q9BRX8	reviewed	PXL2A_HUMAN	Peroxiredoxin-like 2A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) (Redox-regulatory protein FAM213A)	PRXL2A C10orf58 FAM213A PAMM PRO2290 PSEC0139 UNQ611/PRO1198	Homo sapiens (Human)	229	FUNCTION: Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880). {ECO:0000269|PubMed:19951071, ECO:0000269|PubMed:26438880}.	MISCELLANEOUS: The active site cysteines correspond to the redox-active cysteines of peroxiredoxins.	regulation of osteoclast differentiation [GO:0045670]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	antioxidant activity [GO:0016209]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; antioxidant activity [GO:0016209]; regulation of osteoclast differentiation [GO:0045670]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19951071}. Secreted {ECO:0000269|PubMed:26438880}. Note=Secreted from mature adipocytes but not from preadipocytes. {ECO:0000269|PubMed:26438880}.
Q9BRX9	reviewed	WDR83_HUMAN	WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1)	WDR83 MORG1	Homo sapiens (Human)	315	FUNCTION: Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. {ECO:0000250}.		inflammatory response to wounding [GO:0090594]; mRNA splicing, via spliceosome [GO:0000398]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; RNA splicing, via transesterification reactions [GO:0000375]	catalytic step 2 spliceosome [GO:0071013]; endosome membrane [GO:0010008]; spliceosomal complex [GO:0005681]		catalytic step 2 spliceosome [GO:0071013]; endosome membrane [GO:0010008]; spliceosomal complex [GO:0005681]; inflammatory response to wounding [GO:0090594]; mRNA splicing, via spliceosome [GO:0000398]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}.
Q9BRZ2	reviewed	TRI56_HUMAN	E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56)	TRIM56 RNF109	Homo sapiens (Human)	755	FUNCTION: E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904). Promotes also TNFalpha-induced NF-kappa-B signaling by mediating 'Lys-63'-linked ubiquitination TAK1, leading to enhanced interaction between TAK1 and CHUK/IKKalpha (PubMed:35952808). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160). Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). Acts as restriction factor of Zika virus through direct interaction with the viral RNA via its C-terminal region (PubMed:31251739). {ECO:0000250|UniProtKB:Q80VI1, ECO:0000269|PubMed:21289118, ECO:0000269|PubMed:22948160, ECO:0000269|PubMed:29426904, ECO:0000269|PubMed:31251739, ECO:0000269|PubMed:35952808}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21289118}.
Q9BS16	reviewed	CENPK_HUMAN	Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33)	CENPK ICEN37 FKSG14	Homo sapiens (Human)	269	FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18045986}.		chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic sister chromatid segregation [GO:0000070]	cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic sister chromatid segregation [GO:0000070]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Q9BS26	reviewed	ERP44_HUMAN	Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4)	ERP44 KIAA0573 TXNDC4 UNQ532/PRO1075	Homo sapiens (Human)	406	FUNCTION: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652484). May have a role in the control of oxidative protein folding in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230, PubMed:14517240). Required to retain ERO1A and ERO1B in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230). {ECO:0000269|PubMed:11847130, ECO:0000269|PubMed:14517240, ECO:0000269|PubMed:15652484, ECO:0000269|PubMed:29858230}.		cell redox homeostasis [GO:0045454]; glycoprotein metabolic process [GO:0009100]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; specific granule lumen [GO:0035580]	protein disulfide isomerase activity [GO:0003756]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; specific granule lumen [GO:0035580]; protein disulfide isomerase activity [GO:0003756]; cell redox homeostasis [GO:0045454]; glycoprotein metabolic process [GO:0009100]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:11847130, ECO:0000269|PubMed:15652484}.
Q9BS34	reviewed	ZN670_HUMAN	Zinc finger protein 670	ZNF670	Homo sapiens (Human)	389	FUNCTION: May be involved in transcriptional regulation.		cellular lipid metabolic process [GO:0044255]; lipid metabolic process [GO:0006629]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cellular lipid metabolic process [GO:0044255]; lipid metabolic process [GO:0006629]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BS40	reviewed	LXN_HUMAN	Latexin (Endogenous carboxypeptidase inhibitor) (ECI) (Protein MUM) (Tissue carboxypeptidase inhibitor) (TCI)	LXN	Homo sapiens (Human)	222	FUNCTION: Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation. {ECO:0000269|PubMed:15738388}.		detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; inflammatory response [GO:0006954]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	heparin binding [GO:0008201]; metalloendopeptidase inhibitor activity [GO:0008191]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; heparin binding [GO:0008201]; metalloendopeptidase inhibitor activity [GO:0008191]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; inflammatory response [GO:0006954]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q9BS86	reviewed	ZPBP1_HUMAN	Zona pellucida-binding protein 1 (Inner acrosomal membrane IAM38) (Sp38)	ZPBP ZPBP1	Homo sapiens (Human)	351	FUNCTION: Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity). {ECO:0000250|UniProtKB:Q62522, ECO:0000269|PubMed:21911476}.		acrosome assembly [GO:0001675]; binding of sperm to zona pellucida [GO:0007339]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; nucleus [GO:0005634]; zona pellucida receptor complex [GO:0002199]		acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; nucleus [GO:0005634]; zona pellucida receptor complex [GO:0002199]; acrosome assembly [GO:0001675]; binding of sperm to zona pellucida [GO:0007339]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:31985809}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q62522}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62522}. Secreted {ECO:0000305}. Note=First localized in acrosome granule, later migrates to the inner and outer acrosomal membrane. Released after the acrosomal reaction. {ECO:0000250|UniProtKB:Q62522}.
Q9BS91	reviewed	S35A5_HUMAN	UDP-sugar transporter protein SLC35A5 (Solute carrier family 35 member A5)	SLC35A5 UNQ164/PRO190	Homo sapiens (Human)	424	FUNCTION: Probable UDP-sugar:UMP transmembrane antiporter involved in UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport from the cytosol to the lumen of the Golgi. {ECO:0000269|PubMed:2322548, ECO:0000269|PubMed:30641943}.		carbohydrate transport [GO:0008643]	Golgi membrane [GO:0000139]	antiporter activity [GO:0015297]; pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165]	Golgi membrane [GO:0000139]; antiporter activity [GO:0015297]; pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165]; carbohydrate transport [GO:0008643]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:30641943}; Multi-pass membrane protein {ECO:0000255}.
Q9BSA4	reviewed	TTYH2_HUMAN	Protein tweety homolog 2 (hTTY2)	TTYH2 C17orf29	Homo sapiens (Human)	534	FUNCTION: Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation. {ECO:0000269|PubMed:15010458}.			chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]	intracellular calcium activated chloride channel activity [GO:0005229]; volume-sensitive chloride channel activity [GO:0072320]	chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]; intracellular calcium activated chloride channel activity [GO:0005229]; volume-sensitive chloride channel activity [GO:0072320]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9BSA9	reviewed	TM175_HUMAN	Endosomal/lysosomal proton channel TMEM175 (Transmembrane protein 175) (hTMEM175)	TMEM175	Homo sapiens (Human)	504	FUNCTION: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (PubMed:35750034, PubMed:35333573, PubMed:37390818). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (PubMed:35750034). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (PubMed:26317472, PubMed:32267231). May also act as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (PubMed:26317472, PubMed:28723891, PubMed:32228865, PubMed:32267231, PubMed:33505021). The potassium channel activity is however unclear as it was tested in non-physiological conditions for a lysosomal channel (PubMed:35750034). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (PubMed:33505021). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (PubMed:33505021). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:33505021). {ECO:0000269|PubMed:26317472, ECO:0000269|PubMed:28723891, ECO:0000269|PubMed:32228865, ECO:0000269|PubMed:32267231, ECO:0000269|PubMed:33505021, ECO:0000269|PubMed:35333573, ECO:0000269|PubMed:35750034, ECO:0000269|PubMed:37390818}.		lysosomal lumen pH elevation [GO:0035752]; neuron cellular homeostasis [GO:0070050]; phagosome-lysosome fusion [GO:0090385]; potassium ion transmembrane transport [GO:0071805]; proton transmembrane transport [GO:1902600]; regulation of lysosomal lumen pH [GO:0035751]	endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]	arachidonic acid binding [GO:0050544]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; proton channel activity [GO:0015252]	endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; arachidonic acid binding [GO:0050544]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; proton channel activity [GO:0015252]; lysosomal lumen pH elevation [GO:0035752]; neuron cellular homeostasis [GO:0070050]; phagosome-lysosome fusion [GO:0090385]; potassium ion transmembrane transport [GO:0071805]; proton transmembrane transport [GO:1902600]; regulation of lysosomal lumen pH [GO:0035751]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:26317472, ECO:0000269|PubMed:32228865}; Multi-pass membrane protein {ECO:0000269|PubMed:32228865}. Lysosome membrane {ECO:0000269|PubMed:26317472, ECO:0000269|PubMed:31261387, ECO:0000269|PubMed:31658403, ECO:0000269|PubMed:32228865}; Multi-pass membrane protein {ECO:0000269|PubMed:32228865}.
Q9BSB4	reviewed	ATGA1_HUMAN	Autophagy-related protein 101	ATG101 C12orf44 PP894	Homo sapiens (Human)	218	FUNCTION: Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. {ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:19597335}.		autophagosome assembly [GO:0000045]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of autophagy [GO:0010508]; regulation of protein lipidation [GO:1903059]	Atg1/ULK1 kinase complex [GO:1990316]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; phagophore assembly site [GO:0000407]	identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	Atg1/ULK1 kinase complex [GO:1990316]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; phagophore assembly site [GO:0000407]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; autophagosome assembly [GO:0000045]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of autophagy [GO:0010508]; regulation of protein lipidation [GO:1903059]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19597335}. Preautophagosomal structure {ECO:0000269|PubMed:19597335}. Note=Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. {ECO:0000269|PubMed:19597335}.
Q9BSD3	reviewed	RHNO1_HUMAN	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RAD9, RAD1, HUS1-interacting nuclear orphan protein)	RHNO1 C12orf32 RHINO HKMT1188	Homo sapiens (Human)	238	FUNCTION: Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation. {ECO:0000269|PubMed:21659603}.		cell cycle [GO:0007049]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; positive regulation of G0 to G1 transition [GO:0070318]; recombinational repair [GO:0000725]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell cycle [GO:0007049]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; positive regulation of G0 to G1 transition [GO:0070318]; recombinational repair [GO:0000725]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20811708}. Chromosome {ECO:0000269|PubMed:20811708}. Note=Localizes to sites of DNA damage in a H2AX-independent manner.
Q9BSD7	reviewed	NTPCR_HUMAN	Cancer-related nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) (Nucleoside triphosphate phosphohydrolase)	NTPCR C1orf57	Homo sapiens (Human)	190	FUNCTION: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency. {ECO:0000269|PubMed:17291528}.			membrane [GO:0016020]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; CTPase activity [GO:0043273]; GTPase activity [GO:0003924]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; RNA binding [GO:0003723]	membrane [GO:0016020]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; CTPase activity [GO:0043273]; GTPase activity [GO:0003924]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; RNA binding [GO:0003723]	
Q9BSE2	reviewed	TMM79_HUMAN	Transmembrane protein 79 (Mattrin)	TMEM79 MATT	Homo sapiens (Human)	394	FUNCTION: Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity). {ECO:0000250}.		cornification [GO:0070268]; cuticle development [GO:0042335]; epithelial cell maturation [GO:0002070]; establishment of skin barrier [GO:0061436]; hair follicle morphogenesis [GO:0031069]; positive regulation of epidermis development [GO:0045684]; regulated exocytosis [GO:0045055]	lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]	identical protein binding [GO:0042802]	lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]; identical protein binding [GO:0042802]; cornification [GO:0070268]; cuticle development [GO:0042335]; epithelial cell maturation [GO:0002070]; establishment of skin barrier [GO:0061436]; hair follicle morphogenesis [GO:0031069]; positive regulation of epidermis development [GO:0045684]; regulated exocytosis [GO:0045055]	SUBCELLULAR LOCATION: Lysosome {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Colocalized with TGOLN2 in the trans-Golgi network. Colocalized with LAMP1 in the lysosome (By similarity). {ECO:0000250}.
Q9BSE4	reviewed	HERP2_HUMAN	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	HERPUD2	Homo sapiens (Human)	406	FUNCTION: Could be involved in the unfolded protein response (UPR) pathway. {ECO:0000250}.		endoplasmic reticulum unfolded protein response [GO:0030968]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; endoplasmic reticulum unfolded protein response [GO:0030968]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9BSE5	reviewed	GDAH_HUMAN	Guanidino acid hydrolase, mitochondrial (EC 3.5.3.-) (Arginase, mitochondrial) (EC 3.5.3.1) (Guanidinobutyrase, mitochondrial) (EC 3.5.3.7) (Guanidinopropionase, mitochondrial) (EC 3.5.3.17)	AGMAT GDAH	Homo sapiens (Human)	352	FUNCTION: Hydrolyzes linear guanidino acids to form urea and the corresponding amines. Displays specificity for substrates having a negatively charged head group and short chains including taurocyamine, guanidino propanoic and butanoic acids. May protect cells by detoxifying potentially harmful amounts of guanidino acids. Metabolizes L-arginine with low efficiency. {ECO:0000269|PubMed:36543883}.		agmatine biosynthetic process [GO:0097055]; putrescine biosynthetic process from arginine, using agmatinase [GO:0033389]; urea cycle [GO:0000050]	mitochondrion [GO:0005739]	agmatinase activity [GO:0008783]; arginase activity [GO:0004053]; guanidinobutyrase activity [GO:0047971]; guanidinopropionase activity [GO:0047972]; metal ion binding [GO:0046872]	mitochondrion [GO:0005739]; agmatinase activity [GO:0008783]; arginase activity [GO:0004053]; guanidinobutyrase activity [GO:0047971]; guanidinopropionase activity [GO:0047972]; metal ion binding [GO:0046872]; agmatine biosynthetic process [GO:0097055]; putrescine biosynthetic process from arginine, using agmatinase [GO:0033389]; urea cycle [GO:0000050]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255}.
Q9BSF0	reviewed	SMAKA_HUMAN	Small membrane A-kinase anchor protein (Small membrane AKAP) (smAKAP)	C2orf88	Homo sapiens (Human)	95	FUNCTION: Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane. {ECO:0000269|PubMed:23115245}.			plasma membrane [GO:0005886]	protein kinase A regulatory subunit binding [GO:0034237]	plasma membrane [GO:0005886]; protein kinase A regulatory subunit binding [GO:0034237]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23115245}. Note=The GFP-tagged protein has been detected at the plasma membrane, enriched in filopodia and cell-cell junctions. {ECO:0000269|PubMed:23115245}.
Q9BSG1	reviewed	ZNF2_HUMAN	Zinc finger protein 2 (Zinc finger protein 2.2) (Zinc finger protein 661)	ZNF2 ZNF661	Homo sapiens (Human)	425	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BSH4	reviewed	TACO1_HUMAN	Translational activator of cytochrome c oxidase 1 (Coiled-coil domain-containing protein 44) (Translational activator of mitochondrially-encoded cytochrome c oxidase I)	TACO1 CCDC44 PRO0477	Homo sapiens (Human)	297	FUNCTION: Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. {ECO:0000269|PubMed:19503089}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]; motor learning [GO:0061743]; regulation of mitochondrial translation [GO:0070129]	mitochondrion [GO:0005739]	mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; rRNA binding [GO:0019843]	mitochondrion [GO:0005739]; mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; rRNA binding [GO:0019843]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; motor learning [GO:0061743]; regulation of mitochondrial translation [GO:0070129]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19503089}.
Q9BSI4	reviewed	TINF2_HUMAN	TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2)	TINF2 TIN2	Homo sapiens (Human)	451	FUNCTION: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378}.		negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of protein ADP-ribosylation [GO:0010836]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of telomere maintenance [GO:0032206]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of telomere maintenance via telomere lengthening [GO:1904356]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]	chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; perinucleolar chromocenter [GO:0010370]; shelterin complex [GO:0070187]	telomeric DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; perinucleolar chromocenter [GO:0010370]; shelterin complex [GO:0070187]; telomeric DNA binding [GO:0042162]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of protein ADP-ribosylation [GO:0010836]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of telomere maintenance [GO:0032206]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of telomere maintenance via telomere lengthening [GO:1904356]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19279399}. Chromosome, telomere {ECO:0000269|PubMed:19279399}. Note=Associated with telomeres.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus matrix {ECO:0000269|PubMed:19229133}.
Q9BSJ2	reviewed	GCP2_HUMAN	Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97)	TUBGCP2 GCP2	Homo sapiens (Human)	902	FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Plays a role in neuronal migration. {ECO:0000269|PubMed:31630790, ECO:0000269|PubMed:9566967}.		brain development [GO:0007420]; cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; neuron migration [GO:0001764]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]	gamma-tubulin binding [GO:0043015]	centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]; gamma-tubulin binding [GO:0043015]; brain development [GO:0007420]; cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; neuron migration [GO:0001764]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:9566967}.
Q9BSJ6	reviewed	PIMRE_HUMAN	Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1)	PIMREG CATS FAM64A RCS1	Homo sapiens (Human)	248	FUNCTION: During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}.		cell cycle [GO:0007049]; cell division [GO:0051301]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; cell cycle [GO:0007049]; cell division [GO:0051301]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16491119, ECO:0000269|PubMed:19383357}. Nucleus, nucleolus {ECO:0000269|PubMed:19383357}. Note=Partially localizes to the nucleolus. {ECO:0000269|PubMed:19383357}.
Q9BSJ8	reviewed	ESYT1_HUMAN	Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)	ESYT1 FAM62A KIAA0747 MBC2	Homo sapiens (Human)	1104	FUNCTION: Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. {ECO:0000250, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667}.		endoplasmic reticulum-plasma membrane tethering [GO:0061817]; intermembrane lipid transfer [GO:0120009]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091]; phospholipid transfer activity [GO:0120014]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091]; phospholipid transfer activity [GO:0120014]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; intermembrane lipid transfer [GO:0120009]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29469807}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:29469807}; Peripheral membrane protein {ECO:0000269|PubMed:29469807}. Note=Localizes primarily to the endoplasmic reticulum (PubMed:29469807). Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:29469807, PubMed:22250200). {ECO:0000269|PubMed:22250200, ECO:0000269|PubMed:29469807}.
Q9BSK2	reviewed	S2533_HUMAN	Solute carrier family 25 member 33 (Bone marrow stromal cell mitochondrial carrier protein) (BMSC-MCP) (HuBMSC-MCP) (Protein PNC1)	SLC25A33	Homo sapiens (Human)	321	FUNCTION: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:20453889, PubMed:17596519). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (PubMed:14715278). {ECO:0000269|PubMed:14715278, ECO:0000269|PubMed:17596519, ECO:0000269|PubMed:20453889, ECO:0000269|PubMed:25320081}.		cellular response to insulin stimulus [GO:0032869]; cellular response to insulin-like growth factor stimulus [GO:1990314]; mitochondria-nucleus signaling pathway [GO:0031930]; mitochondrial genome maintenance [GO:0000002]; mitochondrial respiratory chain complex III assembly [GO:0034551]; mitochondrial transcription [GO:0006390]; mitochondrion organization [GO:0007005]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; pyrimidine nucleotide import into mitochondrion [GO:1990519]; pyrimidine nucleotide transport [GO:0006864]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of oxidative phosphorylation [GO:0002082]; regulation of reactive oxygen species biosynthetic process [GO:1903426]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	pyrimidine nucleotide transmembrane transporter activity [GO:0015218]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; pyrimidine nucleotide transmembrane transporter activity [GO:0015218]; cellular response to insulin stimulus [GO:0032869]; cellular response to insulin-like growth factor stimulus [GO:1990314]; mitochondria-nucleus signaling pathway [GO:0031930]; mitochondrial genome maintenance [GO:0000002]; mitochondrial respiratory chain complex III assembly [GO:0034551]; mitochondrial transcription [GO:0006390]; mitochondrion organization [GO:0007005]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; pyrimidine nucleotide import into mitochondrion [GO:1990519]; pyrimidine nucleotide transport [GO:0006864]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of oxidative phosphorylation [GO:0002082]; regulation of reactive oxygen species biosynthetic process [GO:1903426]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:14715278}; Multi-pass membrane protein {ECO:0000255}.
Q9BSK4	reviewed	FEM1A_HUMAN	Protein fem-1 homolog A (FEM1a) (FEM1-alpha) (Prostaglandin E receptor 4-associated protein)	FEM1A EPRAP	Homo sapiens (Human)	669	FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33398168, PubMed:33398170). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:33398168, PubMed:33398170). The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (PubMed:33398168, PubMed:33398170). Promotes ubiquitination and degradation of SLBP (PubMed:28118078). Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity). Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity). {ECO:0000250|UniProtKB:Q9Z2G1, ECO:0000269|PubMed:28118078, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:33398168, ECO:0000269|PubMed:33398170}.		negative regulation of inflammatory response [GO:0050728]; positive regulation of inflammatory response [GO:0050729]; protein ubiquitination [GO:0016567]; regulation of ubiquitin-protein transferase activity [GO:0051438]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; ubiquitin ligase complex [GO:0000151]	EP4 subtype prostaglandin E2 receptor binding [GO:0031867]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; ubiquitin ligase complex [GO:0000151]; EP4 subtype prostaglandin E2 receptor binding [GO:0031867]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; negative regulation of inflammatory response [GO:0050728]; positive regulation of inflammatory response [GO:0050729]; protein ubiquitination [GO:0016567]; regulation of ubiquitin-protein transferase activity [GO:0051438]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19406122}. Cytoplasm {ECO:0000305|PubMed:16424369}.
Q9BSL1	reviewed	UBAC1_HUMAN	Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2)	UBAC1 GBDR1 KPC2 UBADC1	Homo sapiens (Human)	405	FUNCTION: Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1 (PubMed:15531880, PubMed:15746103, PubMed:16227581, PubMed:25860612). The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (PubMed:15531880, PubMed:15746103). The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor (PubMed:25860612). Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome (PubMed:16227581). {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:15746103, ECO:0000269|PubMed:16227581, ECO:0000269|PubMed:25860612}.		protein maturation [GO:0051604]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; protein maturation [GO:0051604]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10857748, ECO:0000269|PubMed:15531880}.
Q9BSM1	reviewed	PCGF1_HUMAN	Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)	PCGF1 NSPC1 RNF68	Homo sapiens (Human)	259	FUNCTION: Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479). {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:16943429, ECO:0000269|PubMed:17088287, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:26687479}.		chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]	metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:21282530}.
Q9BSQ5	reviewed	CCM2_HUMAN	Cerebral cavernous malformations 2 protein (Malcavernin)	CCM2 C7orf22 PP10187	Homo sapiens (Human)	444	FUNCTION: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}.		blood vessel endothelial cell differentiation [GO:0060837]; cell-cell junction organization [GO:0045216]; endothelial cell development [GO:0001885]; endothelial tube morphogenesis [GO:0061154]; endothelium development [GO:0003158]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; inner ear development [GO:0048839]; integrin-mediated signaling pathway [GO:0007229]; multicellular organism growth [GO:0035264]; pericardium development [GO:0060039]; regulation of angiogenesis [GO:0045765]; stress-activated MAPK cascade [GO:0051403]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]		cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; blood vessel endothelial cell differentiation [GO:0060837]; cell-cell junction organization [GO:0045216]; endothelial cell development [GO:0001885]; endothelial tube morphogenesis [GO:0061154]; endothelium development [GO:0003158]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; inner ear development [GO:0048839]; integrin-mediated signaling pathway [GO:0007229]; multicellular organism growth [GO:0035264]; pericardium development [GO:0060039]; regulation of angiogenesis [GO:0045765]; stress-activated MAPK cascade [GO:0051403]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9BSR8	reviewed	YIPF4_HUMAN	Protein YIPF4 (YIP1 family member 4)	YIPF4 Nbla11189	Homo sapiens (Human)	244	FUNCTION: Involved in the maintenance of the Golgi structure. {ECO:0000269|PubMed:21757827}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle fusion with Golgi apparatus [GO:0048280]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]		endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle fusion with Golgi apparatus [GO:0048280]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:21757827, ECO:0000269|PubMed:26235900, ECO:0000269|PubMed:27999994}; Multi-pass membrane protein {ECO:0000269|PubMed:21757827}.
Q9BST9	reviewed	RTKN_HUMAN	Rhotekin	RTKN RTKN1	Homo sapiens (Human)	563	FUNCTION: Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}.	MISCELLANEOUS: [Isoform 3]: Incomplete sequence. {ECO:0000269|PubMed:10940294}.	actomyosin contractile ring assembly [GO:0000915]; apoptotic process [GO:0006915]; mitotic cytokinesis [GO:0000281]; regulation of apoptotic process [GO:0042981]; Rho protein signal transduction [GO:0007266]; septin ring organization [GO:0031106]; signal transduction [GO:0007165]	actomyosin contractile ring [GO:0005826]; cytosol [GO:0005829]	GTP binding [GO:0005525]; GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267]	actomyosin contractile ring [GO:0005826]; cytosol [GO:0005829]; GTP binding [GO:0005525]; GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267]; actomyosin contractile ring assembly [GO:0000915]; apoptotic process [GO:0006915]; mitotic cytokinesis [GO:0000281]; regulation of apoptotic process [GO:0042981]; Rho protein signal transduction [GO:0007266]; septin ring organization [GO:0031106]; signal transduction [GO:0007165]	
Q9BSU1	reviewed	PHAF1_HUMAN	Phagosome assembly factor 1	PHAF1 C16orf6 C16orf70	Homo sapiens (Human)	422	FUNCTION: Plays a regulatory role in autophagic activity. In complex with BCAS3, associates with the autophagosome formation site during both non-selective and selective autophagy. {ECO:0000269|PubMed:33499712}.		Golgi to plasma membrane protein transport [GO:0043001]	dendrite [GO:0030425]; phagophore assembly site [GO:0000407]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]		dendrite [GO:0030425]; phagophore assembly site [GO:0000407]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; Golgi to plasma membrane protein transport [GO:0043001]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:33499712}. Preautophagosomal structure {ECO:0000269|PubMed:33499712}. Note=The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner. {ECO:0000269|PubMed:33499712}.
Q9BSU3	reviewed	NAA11_HUMAN	N-alpha-acetyltransferase 11 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog B) (hARD2) (NatA catalytic subunit Naa11)	NAA11 ARD1B ARD2	Homo sapiens (Human)	229	FUNCTION: Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex. {ECO:0000269|PubMed:16638120}.		N-terminal protein amino acid acetylation [GO:0006474]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; NatA complex [GO:0031415]; nucleoplasm [GO:0005654]	peptide alpha-N-acetyltransferase activity [GO:0004596]; peptide-glutamate-alpha-N-acetyltransferase activity [GO:1990190]; peptide-serine-alpha-N-acetyltransferase activity [GO:1990189]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; NatA complex [GO:0031415]; nucleoplasm [GO:0005654]; peptide alpha-N-acetyltransferase activity [GO:0004596]; peptide-glutamate-alpha-N-acetyltransferase activity [GO:1990190]; peptide-serine-alpha-N-acetyltransferase activity [GO:1990189]; N-terminal protein amino acid acetylation [GO:0006474]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16638120}. Nucleus {ECO:0000269|PubMed:16638120}.
Q9BSV6	reviewed	SEN34_HUMAN	tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34)	TSEN34 LENG5 SEN34	Homo sapiens (Human)	310	FUNCTION: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}.	MISCELLANEOUS: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.	mRNA processing [GO:0006397]; tRNA-type intron splice site recognition and cleavage [GO:0000379]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214]	lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; tRNA-intron endonuclease activity [GO:0000213]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214]; lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; tRNA-intron endonuclease activity [GO:0000213]; mRNA processing [GO:0006397]; tRNA-type intron splice site recognition and cleavage [GO:0000379]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15109492}. Nucleus, nucleolus {ECO:0000269|PubMed:15109492}. Note=May be transiently localized in the nucleolus.
Q9BSW2	reviewed	EFC4B_HUMAN	EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46)	CRACR2A EFCAB4B RAB46	Homo sapiens (Human)	731	FUNCTION: [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269|PubMed:20418871, ECO:0000269|PubMed:27016526}.; FUNCTION: [Isoform 2]: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli (PubMed:31092558). During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function (PubMed:31092558). Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 (PubMed:30814157). Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation (PubMed:27016526). In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways (PubMed:27016526). Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function (PubMed:29987160). Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation (PubMed:27016526). {ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:29987160, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}.		activation of store-operated calcium channel activity [GO:0032237]; adaptive immune response [GO:0002250]; endosomal transport [GO:0016197]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of JNK cascade [GO:0046330]; response to histamine [GO:0034776]; store-operated calcium entry [GO:0002115]; T-helper 1 cell differentiation [GO:0045063]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; immunological synapse [GO:0001772]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093]	calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; immunological synapse [GO:0001772]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; activation of store-operated calcium channel activity [GO:0032237]; adaptive immune response [GO:0002250]; endosomal transport [GO:0016197]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of JNK cascade [GO:0046330]; response to histamine [GO:0034776]; store-operated calcium entry [GO:0002115]; T-helper 1 cell differentiation [GO:0045063]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:20418871}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. Cell membrane {ECO:0000269|PubMed:30814157}. Golgi apparatus membrane {ECO:0000269|PubMed:27016526}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27016526}. Vesicle {ECO:0000269|PubMed:27016526}. Note=T-cell activation-induced elevation of intracellular of Ca(2+) stimulates its transport toward the microtubule organizing center (MTOC) (PubMed:30814157). Histamine stimulation induces a trafficking to the MTOC in a GTP-binding-dependent but Ca(2+)-binding-independent manner (PubMed:31092558). Localizes to Golgi membrane in resting T-cells and upon its interaction with VAV1, is translocated from the Golgi membrane to the immunological synapse via subsynaptic vesicles (PubMed:27016526). Its localization in the Golgi membrane requires isoprenylation and GTP-binding (PubMed:27016526). {ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}.
Q9BSW7	reviewed	SYT17_HUMAN	Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII)	SYT17	Homo sapiens (Human)	474	FUNCTION: Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}.		calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]	exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]	exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]; calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q9BSY9	reviewed	DESI2_HUMAN	Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing protein 1) (Protein FAM152A)	DESI2 C1orf121 FAM152A PPPDE1 CGI-146 PNAS-4	Homo sapiens (Human)	194	FUNCTION: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520). {ECO:0000269|PubMed:28483520}.		proteolysis [GO:0006508]	cytoplasm [GO:0005737]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]	cytoplasm [GO:0005737]; cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D291}.
Q9BT04	reviewed	FUZZY_HUMAN	Protein fuzzy homolog	FUZ FY	Homo sapiens (Human)	418	FUNCTION: Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity). {ECO:0000250|UniProtKB:Q3UYI6}.		cilium assembly [GO:0060271]; embryonic body morphogenesis [GO:0010172]; embryonic skeletal system morphogenesis [GO:0048704]; establishment of planar polarity [GO:0001736]; hair follicle development [GO:0001942]; intraciliary transport [GO:0042073]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [GO:2000314]; negative regulation of neural crest formation [GO:0090301]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; positive regulation of cilium assembly [GO:0045724]; protein transport [GO:0015031]; regulation of cilium assembly [GO:1902017]; regulation of smoothened signaling pathway [GO:0008589]; vesicle-mediated transport [GO:0016192]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]		cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; cilium assembly [GO:0060271]; embryonic body morphogenesis [GO:0010172]; embryonic skeletal system morphogenesis [GO:0048704]; establishment of planar polarity [GO:0001736]; hair follicle development [GO:0001942]; intraciliary transport [GO:0042073]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [GO:2000314]; negative regulation of neural crest formation [GO:0090301]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; positive regulation of cilium assembly [GO:0045724]; protein transport [GO:0015031]; regulation of cilium assembly [GO:1902017]; regulation of smoothened signaling pathway [GO:0008589]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q2HZX7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2HZX7}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q3UYI6}.
Q9BT09	reviewed	CNPY3_HUMAN	Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein)	CNPY3 CTG4A ERDA5 PRAT4A TNRC5 HSPC084 UNQ1934/PRO4409	Homo sapiens (Human)	278	FUNCTION: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	innate immune response [GO:0045087]	endoplasmic reticulum lumen [GO:0005788]	signaling receptor binding [GO:0005102]	endoplasmic reticulum lumen [GO:0005788]; signaling receptor binding [GO:0005102]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}.
Q9BT17	reviewed	MTG1_HUMAN	Mitochondrial ribosome-associated GTPase 1 (GTP-binding protein 7) (Mitochondrial GTPase 1)	MTG1 GTPBP7	Homo sapiens (Human)	334	FUNCTION: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity. {ECO:0000269|PubMed:23396448}.		mitochondrial translation [GO:0032543]; regulation of mitochondrial translation [GO:0070129]; regulation of respiratory system process [GO:0044065]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; mitochondrial translation [GO:0032543]; regulation of mitochondrial translation [GO:0070129]; regulation of respiratory system process [GO:0044065]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:12808030, ECO:0000269|PubMed:23396448}; Peripheral membrane protein {ECO:0000269|PubMed:12808030, ECO:0000269|PubMed:23396448}; Matrix side {ECO:0000269|PubMed:12808030, ECO:0000269|PubMed:23396448}.
Q9BT22	reviewed	ALG1_HUMAN	Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) (Asparagine-linked glycosylation protein 1 homolog) (Beta-1,4-mannosyltransferase) (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase) (Mannosyltransferase-1) (MT-1) (hMat-1)	ALG1 HMAT1 HMT1 PSEC0061 UNQ861/PRO1870	Homo sapiens (Human)	464	FUNCTION: Catalyzes the addition of the first of nine mannose moieties to form a dolichol-lipid linked oligosaccharide intermediate required for proper N-linked glycosylation. {ECO:0000269|PubMed:10704531, ECO:0000269|PubMed:14973778, ECO:0000269|PubMed:26931382}.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	chitobiosyldiphosphodolichol beta-mannosyltransferase activity [GO:0004578]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; chitobiosyldiphosphodolichol beta-mannosyltransferase activity [GO:0004578]; mannosyltransferase activity [GO:0000030]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9BT23	reviewed	LIMD2_HUMAN	LIM domain-containing protein 2	LIMD2 SB143	Homo sapiens (Human)	127	FUNCTION: Acts as an activator of the protein-kinase ILK, thereby regulating cell motility (PubMed:24590809). {ECO:0000269|PubMed:24590809}.	MISCELLANEOUS: May play a role in tumor progression via its ability to activate the ILK protein-kinase activity. {ECO:0000269|PubMed:24590809}.	actin filament bundle assembly [GO:0051017]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; metal ion binding [GO:0046872]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; metal ion binding [GO:0046872]; actin filament bundle assembly [GO:0051017]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24590809}. Nucleus {ECO:0000269|PubMed:24590809}. Note=Mainly found in cytoplasm, concentrated in membrane ruffles and in streaks reminiscent of focal adhesion plaques (PubMed:24590809). Also found in nucleus (PubMed:24590809). {ECO:0000269|PubMed:24590809}.
Q9BT25	reviewed	HAUS8_HUMAN	HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48)	HAUS8 HICE1	Homo sapiens (Human)	410	FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.		cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; nuclear microtubule [GO:0005880]; spindle pole [GO:0000922]	microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; nuclear microtubule [GO:0005880]; spindle pole [GO:0000922]; microtubule binding [GO:0008017]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000305|PubMed:19369198}. Note=During interphase, primarily cytoplasmic and associates with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During anaphase and telophase, additionally associates with the spindle midzone and midbody, respectively. Localizes to mitotic spindle microtubules. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}.
Q9BT30	reviewed	ALKB7_HUMAN	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 7) (Spermatogenesis cell proliferation-related protein) (Spermatogenesis-associated protein 11)	ALKBH7 ABH7 SPATA11 UNQ6002/PRO34564	Homo sapiens (Human)	221	FUNCTION: May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9D6Z0, ECO:0000269|PubMed:23666923, ECO:0000269|PubMed:25122757}.		DNA damage response [GO:0006974]; fatty acid metabolic process [GO:0006631]; regulation of lipid storage [GO:0010883]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872]; DNA damage response [GO:0006974]; fatty acid metabolic process [GO:0006631]; regulation of lipid storage [GO:0010883]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:23666923}.
Q9BT40	reviewed	INP5K_HUMAN	Inositol polyphosphate 5-phosphatase K (EC 3.1.3.56) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Skeletal muscle and kidney-enriched inositol phosphatase)	INPP5K PPS SKIP	Homo sapiens (Human)	448	FUNCTION: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PubMed:10753883, PubMed:16824732). Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (PubMed:10753883). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity). {ECO:0000250|UniProtKB:Q8C5L6, ECO:0000269|PubMed:10753883, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:28190456, ECO:0000269|PubMed:28190459}.		actin cytoskeleton organization [GO:0030036]; cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hormone stimulus [GO:0032870]; cellular response to insulin stimulus [GO:0032869]; cellular response to tumor necrosis factor [GO:0071356]; dephosphorylation [GO:0016311]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; in utero embryonic development [GO:0001701]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of dephosphorylation [GO:0035305]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucose transmembrane transport [GO:0010829]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of stress fiber assembly [GO:0051497]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of renal water transport [GO:2001153]; positive regulation of urine volume [GO:0035810]; protein localization to plasma membrane [GO:0072659]; regulation of glycogen biosynthetic process [GO:0005979]; ruffle assembly [GO:0097178]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; trans-Golgi network [GO:0005802]	inositol bisphosphate phosphatase activity [GO:0016312]; inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; lipid phosphatase activity [GO:0042577]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol trisphosphate phosphatase activity [GO:0034594]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; vasopressin receptor activity [GO:0005000]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; trans-Golgi network [GO:0005802]; inositol bisphosphate phosphatase activity [GO:0016312]; inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; lipid phosphatase activity [GO:0042577]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol trisphosphate phosphatase activity [GO:0034594]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; vasopressin receptor activity [GO:0005000]; actin cytoskeleton organization [GO:0030036]; cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hormone stimulus [GO:0032870]; cellular response to insulin stimulus [GO:0032869]; cellular response to tumor necrosis factor [GO:0071356]; dephosphorylation [GO:0016311]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; in utero embryonic development [GO:0001701]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of dephosphorylation [GO:0035305]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucose transmembrane transport [GO:0010829]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of stress fiber assembly [GO:0051497]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of renal water transport [GO:2001153]; positive regulation of urine volume [GO:0035810]; protein localization to plasma membrane [GO:0072659]; regulation of glycogen biosynthetic process [GO:0005979]; ruffle assembly [GO:0097178]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:12536145, ECO:0000269|PubMed:26940976, ECO:0000269|PubMed:28190456}. Cytoplasm {ECO:0000269|PubMed:10753883}. Note=Following stimulation with EGF, translocates to membrane ruffles (PubMed:12536145, PubMed:26940976). Concentrated at the periphery of the nucleus (PubMed:10753883). {ECO:0000269|PubMed:10753883, ECO:0000269|PubMed:12536145, ECO:0000269|PubMed:26940976}.
Q9BT43	reviewed	RPC7L_HUMAN	DNA-directed RNA polymerase III subunit RPC7-like (RNA polymerase III subunit C7-like) (DNA-directed RNA polymerase III subunit G-like) (RNA polymerase III 32 kDa beta subunit) (RPC32-beta)	POLR3GL	Homo sapiens (Human)	218	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. {ECO:0000269|PubMed:20154270}.		transcription by RNA polymerase III [GO:0006383]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20154270}.
Q9BT49	reviewed	THAP7_HUMAN	THAP domain-containing protein 7	THAP7	Homo sapiens (Human)	309	FUNCTION: Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors. {ECO:0000269|PubMed:15561719}.		chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	C2H2 zinc finger domain binding [GO:0070742]; DNA binding [GO:0003677]; general transcription initiation factor binding [GO:0140296]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; histone reader activity [GO:0140566]; identical protein binding [GO:0042802]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; phosphorylated histone binding [GO:0106153]; transcription corepressor binding [GO:0001222]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; C2H2 zinc finger domain binding [GO:0070742]; DNA binding [GO:0003677]; general transcription initiation factor binding [GO:0140296]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; histone reader activity [GO:0140566]; identical protein binding [GO:0042802]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; phosphorylated histone binding [GO:0106153]; transcription corepressor binding [GO:0001222]; chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
Q9BT56	reviewed	SPXN_HUMAN	Spexin (NPQ) (Neuropeptide Q) (Spexin hormone) [Cleaved into: Spexin-1; Spexin-2 (NPQ 53-70)]	SPX C12orf39	Homo sapiens (Human)	116	FUNCTION: Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). {ECO:0000250}.; FUNCTION: [Spexin-1]: Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231). Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:17284679, ECO:0000269|PubMed:24517231}.; FUNCTION: [Spexin-2]: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity). {ECO:0000250}.		long-chain fatty acid import into cell [GO:0044539]; negative regulation of appetite [GO:0032099]; negative regulation of heart rate [GO:0010459]; negative regulation of renal sodium excretion [GO:0035814]; positive regulation of gastro-intestinal system smooth muscle contraction [GO:1904306]; positive regulation of systemic arterial blood pressure [GO:0003084]; regulation of sensory perception of pain [GO:0051930]	cytoplasm [GO:0005737]; dense core granule [GO:0031045]; extracellular space [GO:0005615]; transport vesicle [GO:0030133]	neuropeptide hormone activity [GO:0005184]	cytoplasm [GO:0005737]; dense core granule [GO:0031045]; extracellular space [GO:0005615]; transport vesicle [GO:0030133]; neuropeptide hormone activity [GO:0005184]; long-chain fatty acid import into cell [GO:0044539]; negative regulation of appetite [GO:0032099]; negative regulation of heart rate [GO:0010459]; negative regulation of renal sodium excretion [GO:0035814]; positive regulation of gastro-intestinal system smooth muscle contraction [GO:1904306]; positive regulation of systemic arterial blood pressure [GO:0003084]; regulation of sensory perception of pain [GO:0051930]	SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Secreted via the classical ER/Golgi-dependent pathway into the extracellular medium largely as a full-length protein without the signal peptide, and not as a hydrolyzed and amidated peptide (PubMed:19193193, PubMed:17284679). Localized extracellularly surrounding the villous trophoblastic cells. Detected in the serum.
Q9BT67	reviewed	NFIP1_HUMAN	NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein)	NDFIP1 N4WBP5 PSEC0192 PSEC0223	Homo sapiens (Human)	221	FUNCTION: Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion (PubMed:26319551). Restricts the production of pro-inflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC (By similarity). Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells (By similarity). Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS (PubMed:23087404). Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation (PubMed:26363003). In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity (PubMed:19706893). Important for normal development of dendrites and dendritic spines in cortex (By similarity). Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046). Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH (By similarity). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (PubMed:20534535). Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity (PubMed:25801959). {ECO:0000250|UniProtKB:Q8R0W6, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:19706893, ECO:0000269|PubMed:20534535, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:25801959, ECO:0000269|PubMed:26319551, ECO:0000269|PubMed:26363003}.		CD4-positive, alpha-beta T cell proliferation [GO:0035739]; intracellular iron ion homeostasis [GO:0006879]; metal ion transport [GO:0030001]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of isotype switching to IgE isotypes [GO:0048294]; negative regulation of protein transport [GO:0051224]; negative regulation of transporter activity [GO:0032410]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein ubiquitination [GO:0031398]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of lymphocyte differentiation [GO:0045619]; regulation of myeloid leukocyte differentiation [GO:0002761]; ubiquitin-dependent protein catabolic process [GO:0006511]; vacuolar transport [GO:0007034]	cell cortex [GO:0005938]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]	WW domain binding [GO:0050699]	cell cortex [GO:0005938]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]; WW domain binding [GO:0050699]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; intracellular iron ion homeostasis [GO:0006879]; metal ion transport [GO:0030001]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of isotype switching to IgE isotypes [GO:0048294]; negative regulation of protein transport [GO:0051224]; negative regulation of transporter activity [GO:0032410]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein ubiquitination [GO:0031398]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of lymphocyte differentiation [GO:0045619]; regulation of myeloid leukocyte differentiation [GO:0002761]; ubiquitin-dependent protein catabolic process [GO:0006511]; vacuolar transport [GO:0007034]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:20534535}; Multi-pass membrane protein {ECO:0000269|PubMed:20534535}. Golgi apparatus membrane {ECO:0000269|PubMed:26363003}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q8R0W6}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q5U2S1}. Secreted {ECO:0000269|PubMed:18819914}. Note=Detected in exosomes and secreted via the exosomal pathway (PubMed:18819914).
Q9BT78	reviewed	CSN4_HUMAN	COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)	COPS4 CSN4	Homo sapiens (Human)	406	FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}.		protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]	cell junction [GO:0030054]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021]	deNEDDylase activity [GO:0019784]	cell junction [GO:0030054]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021]; deNEDDylase activity [GO:0019784]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:21102408}.
Q9BT81	reviewed	SOX7_HUMAN	Transcription factor SOX-7	SOX7	Homo sapiens (Human)	388	FUNCTION: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; endoderm formation [GO:0001706]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA-templated transcription [GO:0006355]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; endoderm formation [GO:0001706]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Cytoplasm {ECO:0000269|PubMed:18819930}.
Q9BT88	reviewed	SYT11_HUMAN	Synaptotagmin-11 (Synaptotagmin XI) (SytXI)	SYT11 KIAA0080	Homo sapiens (Human)	431	FUNCTION: Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822). {ECO:0000250|UniProtKB:Q9R0N3, ECO:0000269|PubMed:27278822}.		autophagy [GO:0006914]; calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; establishment of vesicle localization [GO:0051650]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of cytokine production [GO:0001818]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of endocytosis [GO:0045806]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of phagocytosis [GO:0050765]; negative regulation of tumor necrosis factor production [GO:0032720]; plasma membrane repair [GO:0001778]; positive regulation of protein localization to phagocytic vesicle [GO:1905171]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of defense response to bacterium [GO:1900424]; regulation of dopamine secretion [GO:0014059]; regulation of phagosome maturation [GO:1905162]; regulation of synaptic vesicle endocytosis [GO:1900242]; vesicle fusion [GO:0006906]	axon [GO:0030424]; clathrin-coated vesicle membrane [GO:0030665]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; dopaminergic synapse [GO:0098691]; early phagosome [GO:0032009]; excitatory synapse [GO:0060076]; exocytic vesicle [GO:0070382]; inhibitory synapse [GO:0060077]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; phagocytic cup [GO:0001891]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982]	beta-tubulin binding [GO:0048487]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; translation initiation factor binding [GO:0031369]; ubiquitin protein ligase binding [GO:0031625]	axon [GO:0030424]; clathrin-coated vesicle membrane [GO:0030665]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; dopaminergic synapse [GO:0098691]; early phagosome [GO:0032009]; excitatory synapse [GO:0060076]; exocytic vesicle [GO:0070382]; inhibitory synapse [GO:0060077]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; phagocytic cup [GO:0001891]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982]; beta-tubulin binding [GO:0048487]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; translation initiation factor binding [GO:0031369]; ubiquitin protein ligase binding [GO:0031625]; autophagy [GO:0006914]; calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; establishment of vesicle localization [GO:0051650]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of cytokine production [GO:0001818]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of endocytosis [GO:0045806]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of phagocytosis [GO:0050765]; negative regulation of tumor necrosis factor production [GO:0032720]; plasma membrane repair [GO:0001778]; positive regulation of protein localization to phagocytic vesicle [GO:1905171]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of defense response to bacterium [GO:1900424]; regulation of dopamine secretion [GO:0014059]; regulation of phagosome maturation [GO:1905162]; regulation of synaptic vesicle endocytosis [GO:1900242]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000305|PubMed:12925569}; Single-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:Q9R0N3}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9R0N3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9R0N3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N3}. Lysosome membrane {ECO:0000250|UniProtKB:Q9R0N3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N3}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9R0N3}. Cell projection, axon {ECO:0000269|PubMed:12925569}. Cell projection, dendrite {ECO:0000269|PubMed:12925569}. Postsynaptic density {ECO:0000250|UniProtKB:Q9R0N3}. Recycling endosome membrane {ECO:0000250|UniProtKB:O08835}; Single-pass membrane protein {ECO:0000250|UniProtKB:O08835}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:O08835}; Single-pass membrane protein {ECO:0000250|UniProtKB:O08835}. Perikaryon {ECO:0000269|PubMed:12925569}. Note=Localized in vesicles that travels in axonal and dendritic shafts in both anterograde and retrograde directions. In macrophages and microglia, recruited in phagosomes at early stages of phagocytosis (By similarity). Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients (PubMed:12925569). {ECO:0000250|UniProtKB:Q9R0N3, ECO:0000269|PubMed:12925569}.
Q9BT92	reviewed	TCHP_HUMAN	Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein)	TCHP	Homo sapiens (Human)	498	FUNCTION: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598). {ECO:0000269|PubMed:15731013, ECO:0000269|PubMed:18931701, ECO:0000269|PubMed:25270598}.		apoptotic process [GO:0006915]; cell projection organization [GO:0030030]; negative regulation of cell growth [GO:0030308]; negative regulation of cilium assembly [GO:1902018]	apical cortex [GO:0045179]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; desmosome [GO:0030057]; keratin filament [GO:0045095]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]		apical cortex [GO:0045179]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; desmosome [GO:0030057]; keratin filament [GO:0045095]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; apoptotic process [GO:0006915]; cell projection organization [GO:0030030]; negative regulation of cell growth [GO:0030308]; negative regulation of cilium assembly [GO:1902018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15731013}. Cytoplasm {ECO:0000269|PubMed:18931701}. Cell membrane {ECO:0000305|PubMed:15731013, ECO:0000305|PubMed:18931701}. Mitochondrion {ECO:0000269|PubMed:18931701}. Cell junction, desmosome {ECO:0000269|PubMed:15731013}.
Q9BTA9	reviewed	WAC_HUMAN	WW domain-containing adapter protein with coiled-coil	WAC KIAA1844	Homo sapiens (Human)	647	FUNCTION: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of macroautophagy [GO:0016239]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of macroautophagy [GO:0016239]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q924H7}. Nucleus {ECO:0000269|PubMed:21329877}. Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes. {ECO:0000250|UniProtKB:Q924H7}.
Q9BTC0	reviewed	DIDO1_HUMAN	Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1)	DIDO1 C20orf158 DATF1 KIAA0333	Homo sapiens (Human)	2240	FUNCTION: Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}.	MISCELLANEOUS: Defects in DIDO1 may be a cause of myeloid neoplasms.	apoptotic signaling pathway [GO:0097190]; DNA-templated transcription [GO:0006351]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle [GO:0005819]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle [GO:0005819]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; apoptotic signaling pathway [GO:0097190]; DNA-templated transcription [GO:0006351]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00651}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23831028}. Note=Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis. {ECO:0000250}.
Q9BTC8	reviewed	MTA3_HUMAN	Metastasis-associated protein MTA3	MTA3 KIAA1266	Homo sapiens (Human)	594	FUNCTION: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:12705869, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082). {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.		chromatin remodeling [GO:0006338]; G2/M transition of mitotic cell cycle [GO:0000086]; granulosa cell proliferation [GO:1990739]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of granulosa cell proliferation [GO:1904197]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]	chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; NuRD complex binding [GO:0120325]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; NuRD complex binding [GO:0120325]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; chromatin remodeling [GO:0006338]; G2/M transition of mitotic cell cycle [GO:0000086]; granulosa cell proliferation [GO:1990739]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of granulosa cell proliferation [GO:1904197]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Cytoplasm {ECO:0000250|UniProtKB:Q924K8}.
Q9BTD3	reviewed	TM121_HUMAN	Transmembrane protein 121	TMEM121 HHOLE	Homo sapiens (Human)	319	FUNCTION: May play a role in MAPK signaling. {ECO:0000269|PubMed:15950185}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=May localize to the plasma membrane. {ECO:0000269|PubMed:15950185}.
Q9BTD8	reviewed	RBM42_HUMAN	RNA-binding protein 42 (RNA-binding motif protein 42)	RBM42	Homo sapiens (Human)	480	FUNCTION: Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. {ECO:0000250}.		mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Upon stress response, localizes with HNRNPK in cytoplasmic aggregates of stalled translational preinitiation complexes called stress granules. {ECO:0000250}.
Q9BTE1	reviewed	DCTN5_HUMAN	Dynactin subunit 5 (Dynactin subunit p25)	DCTN5	Homo sapiens (Human)	182	FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000269|PubMed:23455152}.		aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; ventricular septum development [GO:0003281]	centrosome [GO:0005813]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; kinetochore [GO:0000776]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]		centrosome [GO:0005813]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; kinetochore [GO:0000776]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0A286ZK88}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:23455152}.
Q9BTE3	reviewed	MCMBP_HUMAN	Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein)	MCMBP C10orf119	Homo sapiens (Human)	642	FUNCTION: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}.		cell division [GO:0051301]; DNA-templated DNA replication [GO:0006261]; sister chromatid cohesion [GO:0007062]	cell junction [GO:0030054]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	cell junction [GO:0030054]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; cell division [GO:0051301]; DNA-templated DNA replication [GO:0006261]; sister chromatid cohesion [GO:0007062]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17296731}. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.
Q9BTE6	reviewed	AASD1_HUMAN	Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1)	AARSD1	Homo sapiens (Human)	412	FUNCTION: Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. {ECO:0000305}.	alanyl-tRNA aminoacylation [GO:0006419]; regulation of translational fidelity [GO:0006450]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	alanine-tRNA ligase activity [GO:0004813]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; Ser-tRNA(Ala) hydrolase activity [GO:0002196]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; alanine-tRNA ligase activity [GO:0004813]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; Ser-tRNA(Ala) hydrolase activity [GO:0002196]; alanyl-tRNA aminoacylation [GO:0006419]; regulation of translational fidelity [GO:0006450]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9BTE7	reviewed	DCNL5_HUMAN	DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5)	DCUN1D5 SCCRO5	Homo sapiens (Human)	237	FUNCTION: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) (PubMed:26906416, PubMed:23201271, PubMed:19617556). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth (PubMed:23098533, PubMed:24192928). {ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23098533, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:24192928, ECO:0000269|PubMed:26906416}.		DNA damage response [GO:0006974]; positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]; regulation of cell growth [GO:0001558]; regulation of protein neddylation [GO:2000434]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle [GO:0005819]; ubiquitin ligase complex [GO:0000151]	cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle [GO:0005819]; ubiquitin ligase complex [GO:0000151]; cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182]; DNA damage response [GO:0006974]; positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]; regulation of cell growth [GO:0001558]; regulation of protein neddylation [GO:2000434]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:23098533, ECO:0000269|PubMed:26906416}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Note=Subcellular localization is independent of the interaction with cullins. {ECO:0000269|PubMed:26906416}.
Q9BTK6	reviewed	PAGR1_HUMAN	PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1)	PAGR1 C16orf53 PA1	Homo sapiens (Human)	254	FUNCTION: Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}.		DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]	histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear estrogen receptor binding [GO:0030331]	histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear estrogen receptor binding [GO:0030331]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19039327}.
Q9BTL3	reviewed	RAMAC_HUMAN	RNA guanine-N7 methyltransferase activating subunit (Protein FAM103A1) (RNA guanine-7 methyltransferase activating subunit) (RNMT-activating mRNA cap methyltransferase subunit) (RNMT-activating mini protein) (RAM)	RAMAC C15orf18 FAM103A1 RAMMET	Homo sapiens (Human)	118	FUNCTION: Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871). Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT (PubMed:27422871). Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306). Binds RNA (PubMed:22099306). {ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871}.		7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259]; recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [GO:0036031]; RNA 5'-cap (guanine-N7)-methylation [GO:0106005]	mRNA cap binding complex [GO:0005845]; mRNA cap methyltransferase complex [GO:0031533]; nucleus [GO:0005634]	enzyme activator activity [GO:0008047]; molecular function activator activity [GO:0140677]; RNA binding [GO:0003723]	mRNA cap binding complex [GO:0005845]; mRNA cap methyltransferase complex [GO:0031533]; nucleus [GO:0005634]; enzyme activator activity [GO:0008047]; molecular function activator activity [GO:0140677]; RNA binding [GO:0003723]; 7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259]; recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [GO:0036031]; RNA 5'-cap (guanine-N7)-methylation [GO:0106005]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22099306}.
Q9BTL4	reviewed	IER2_HUMAN	Immediate early response gene 2 protein (Protein ETR101)	IER2 ETR101 PIP92	Homo sapiens (Human)	223	FUNCTION: DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713). {ECO:0000250|UniProtKB:B7SXM5, ECO:0000250|UniProtKB:Q6P7D3, ECO:0000269|PubMed:19584537, ECO:0000269|PubMed:22120713}.		cell motility [GO:0048870]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to fibroblast growth factor [GO:0071774]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; cell motility [GO:0048870]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to fibroblast growth factor [GO:0071774]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22120713}. Nucleus {ECO:0000269|PubMed:22120713}. Note=Cytoplasmic during quiescence, translocates to the nucleus upon stimulation. {ECO:0000269|PubMed:22120713}.
Q9BTM9	reviewed	URM1_HUMAN	Ubiquitin-related modifier 1	URM1 C9orf74	Homo sapiens (Human)	101	FUNCTION: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. {ECO:0000255|HAMAP-Rule:MF_03048, ECO:0000269|PubMed:19017811, ECO:0000269|PubMed:21209336}.		protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble uridine modification [GO:0002098]	cytosol [GO:0005829]; nucleus [GO:0005634]	protein tag activity [GO:0031386]; sulfur carrier activity [GO:0097163]	cytosol [GO:0005829]; nucleus [GO:0005634]; protein tag activity [GO:0031386]; sulfur carrier activity [GO:0097163]; protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble uridine modification [GO:0002098]	SUBCELLULAR LOCATION: Cytoplasm.
Q9BTN0	reviewed	LRFN3_HUMAN	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (Synaptic adhesion-like molecule 4)	LRFN3 SALM4 UNQ5865/PRO34192	Homo sapiens (Human)	628	FUNCTION: Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity). {ECO:0000250}.		regulation of presynapse assembly [GO:1905606]; regulation of synaptic membrane adhesion [GO:0099179]; synaptic membrane adhesion [GO:0099560]	axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]		axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]; regulation of presynapse assembly [GO:1905606]; regulation of synaptic membrane adhesion [GO:0099179]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Synapse {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}.
Q9BTP6	reviewed	ZBED2_HUMAN	Zinc finger BED domain-containing protein 2	ZBED2	Homo sapiens (Human)	218	FUNCTION: Transcriptional regulator which has intrinsic repressor activity and which competes with the transcriptional activator IRF1 for binding to the 5'-[CA]GAA[AC]C[CT]-3' consensus sequence in gene promoters (PubMed:32385160). May thereby play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269|PubMed:31552090, ECO:0000269|PubMed:32385160}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of keratinocyte differentiation [GO:0045618]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of keratinocyte differentiation [GO:0045618]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:32385160}.
Q9BTP7	reviewed	FAP24_HUMAN	Fanconi anemia core complex-associated protein 24 (Fanconi anemia-associated protein of 24 kDa)	FAAP24 C19orf40	Homo sapiens (Human)	215	FUNCTION: Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. {ECO:0000269|PubMed:17289582}.		interstrand cross-link repair [GO:0036297]	chromatin [GO:0000785]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]	chromatin [GO:0000785]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; interstrand cross-link repair [GO:0036297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17289582}.
Q9BTT0	reviewed	AN32E_HUMAN	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein) (LANP-L)	ANP32E	Homo sapiens (Human)	268	FUNCTION: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. {ECO:0000269|PubMed:24463511}.		chromatin organization [GO:0006325]; regulation of apoptotic process [GO:0042981]	cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]	histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; phosphatase inhibitor activity [GO:0019212]; protein folding chaperone [GO:0044183]	cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; phosphatase inhibitor activity [GO:0019212]; protein folding chaperone [GO:0044183]; chromatin organization [GO:0006325]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q9BTT4	reviewed	MED10_HUMAN	Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) (Transformation-related gene 17 protein) (TRG-17) (Transformation-related gene 20 protein) (TRG-20)	MED10 L6 TRG17 TRG20	Homo sapiens (Human)	135	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.		positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; RNA polymerase II preinitiation complex assembly [GO:0051123]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BTU6	reviewed	P4K2A_HUMAN	Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha)	PI4K2A	Homo sapiens (Human)	479	FUNCTION: Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}.		endosome organization [GO:0007032]; Golgi organization [GO:0007030]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; growing cell tip [GO:0035838]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; trans-Golgi network [GO:0005802]	1-phosphatidylinositol 4-kinase activity [GO:0004430]; AP-3 adaptor complex binding [GO:0035651]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; growing cell tip [GO:0035838]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; trans-Golgi network [GO:0005802]; 1-phosphatidylinositol 4-kinase activity [GO:0004430]; AP-3 adaptor complex binding [GO:0035651]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; endosome organization [GO:0007032]; Golgi organization [GO:0007030]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12324459, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:22535966}; Lipid-anchor {ECO:0000269|PubMed:22535966}. Membrane raft {ECO:0000269|PubMed:11279162}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q2TBE6}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q2TBE6}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q2TBE6}. Mitochondrion {ECO:0000250|UniProtKB:Q2TBE6}. Endosome {ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:23146885}. Cytoplasmic vesicle {ECO:0000269|PubMed:16443754}. Membrane {ECO:0000269|PubMed:24675427}; Lipid-anchor {ECO:0000269|PubMed:24675427}. Cell membrane {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754}. Perikaryon {ECO:0000250|UniProtKB:Q2TBE6}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q2TBE6}. Note=Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. Transported from neuronal cell body to neuron projections and neurite tips in a BLOC-1- and AP-3-complexes-dependent manner. {ECO:0000250|UniProtKB:Q2TBE6}.
Q9BTV4	reviewed	TMM43_HUMAN	Transmembrane protein 43 (Protein LUMA)	TMEM43 UNQ2564/PRO6244	Homo sapiens (Human)	400	FUNCTION: May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (PubMed:27991920). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination (PubMed:34050020). {ECO:0000250|UniProtKB:Q9DBS1, ECO:0000269|PubMed:27991920, ECO:0000269|PubMed:32614325, ECO:0000269|PubMed:34050020}.		innate immune response [GO:0045087]; lipid metabolic process [GO:0006629]; nuclear membrane organization [GO:0071763]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; protein self-association [GO:0043621]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; protein self-association [GO:0043621]; innate immune response [GO:0045087]; lipid metabolic process [GO:0006629]; nuclear membrane organization [GO:0071763]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:32614325}. Nucleus inner membrane; Multi-pass membrane protein. Cell membrane {ECO:0000269|PubMed:34050020}. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity). {ECO:0000250}.
Q9BTV5	reviewed	FSD1_HUMAN	Fibronectin type III and SPRY domain-containing protein 1 (MID1-related protein 1) (Microtubule-associated protein GLFND)	FSD1 GLFND MIR1 VLP27	Homo sapiens (Human)	496	FUNCTION: May be involved in microtubule organization and stabilization. {ECO:0000269|PubMed:12154070, ECO:0000269|PubMed:12445389}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; regulation of cell division [GO:0051302]; regulation of cytokinesis [GO:0032465]; regulation of mitotic spindle organization [GO:0060236]	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; cell cycle [GO:0007049]; cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; regulation of cell division [GO:0051302]; regulation of cytokinesis [GO:0032465]; regulation of mitotic spindle organization [GO:0060236]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Cleavage furrow. Note=Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associate with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle.
Q9BTW9	reviewed	TBCD_HUMAN	Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D)	TBCD KIAA0988 SSD1 TFCD PP1096	Homo sapiens (Human)	1192	FUNCTION: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374). {ECO:0000269|PubMed:10722852, ECO:0000269|PubMed:10831612, ECO:0000269|PubMed:11847227, ECO:0000269|PubMed:20740604, ECO:0000269|PubMed:27666370, ECO:0000269|PubMed:27666374, ECO:0000269|PubMed:28158450}.		adherens junction assembly [GO:0034333]; bicellular tight junction assembly [GO:0070830]; cell morphogenesis involved in neuron differentiation [GO:0048667]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of microtubule polymerization [GO:0031115]; post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]	beta-tubulin binding [GO:0048487]; GTPase activator activity [GO:0005096]; protein-folding chaperone binding [GO:0051087]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; beta-tubulin binding [GO:0048487]; GTPase activator activity [GO:0005096]; protein-folding chaperone binding [GO:0051087]; adherens junction assembly [GO:0034333]; bicellular tight junction assembly [GO:0070830]; cell morphogenesis involved in neuron differentiation [GO:0048667]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of microtubule polymerization [GO:0031115]; post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:Q28205}. Lateral cell membrane {ECO:0000250|UniProtKB:Q28205}. Cytoplasm {ECO:0000250|UniProtKB:Q28205}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q28205}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27666370}. Note=Localized in cell-cell contacts. {ECO:0000250|UniProtKB:Q28205}.
Q9BTX1	reviewed	NDC1_HUMAN	Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48)	NDC1 TMEM48	Homo sapiens (Human)	674	FUNCTION: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}.	MISCELLANEOUS: Depletion of NDC1 from HeLa cells interferes with the assembly of phenylalanine-glycine (FG) repeat Nups into nuclear pore complexes.	homologous chromosome pairing at meiosis [GO:0007129]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore localization [GO:0051664]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; spermatogenesis [GO:0007283]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore transmembrane ring [GO:0070762]; plasma membrane [GO:0005886]	protein-macromolecule adaptor activity [GO:0030674]; structural constituent of nuclear pore [GO:0017056]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore transmembrane ring [GO:0070762]; plasma membrane [GO:0005886]; protein-macromolecule adaptor activity [GO:0030674]; structural constituent of nuclear pore [GO:0017056]; homologous chromosome pairing at meiosis [GO:0007129]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore localization [GO:0051664]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex.
Q9BTX3	reviewed	TM208_HUMAN	Transmembrane protein 208	TMEM208 HSPC171	Homo sapiens (Human)	173	FUNCTION: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. {ECO:0000269|PubMed:23691174}.		autophagy [GO:0006914]; vacuolar protein processing [GO:0006624]	endoplasmic reticulum membrane [GO:0005789]; vacuole [GO:0005773]		endoplasmic reticulum membrane [GO:0005789]; vacuole [GO:0005773]; autophagy [GO:0006914]; vacuolar protein processing [GO:0006624]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23691174}; Multi-pass membrane protein {ECO:0000269|PubMed:23691174}.
Q9BTY2	reviewed	FUCO2_HUMAN	Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2)	FUCA2 PSEC0151 UNQ227/PRO260	Homo sapiens (Human)	467	FUNCTION: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.		fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]; regulation of entry of bacterium into host cell [GO:2000535]; response to bacterium [GO:0009617]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]	alpha-L-fucosidase activity [GO:0004560]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; alpha-L-fucosidase activity [GO:0004560]; fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]; regulation of entry of bacterium into host cell [GO:2000535]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BTZ2	reviewed	DHRS4_HUMAN	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase) (CR) (NADPH-dependent retinol dehydrogenase/reductase) (NRDR) (humNRDR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (SCAD-SRL) (Short chain dehydrogenase/reductase family 25C member 2) (Protein SDR25C2) (Short-chain dehydrogenase/reductase family member 4)	DHRS4 SDR25C2 UNQ851/PRO1800	Homo sapiens (Human)	278	FUNCTION: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones (PubMed:18571493, PubMed:19056333). Reduces 3-ketosteroids and benzil into 3beta-hydroxysteroids and R-benzoin, respectively, in contrast to the stereoselectivity of non-primate DHRS4s which produce 3alpha-hydroxysteroids and S-benzoin (PubMed:19056333). Diplays low activity toward all-trans-retinal and no activity toward 9-cis-retinal as compared to non-primate mammals (PubMed:18571493, PubMed:19056333). In the reverse reaction, catalyze the NAD-dependent oxidation of 3beta-hydroxysteroids and alcohol, but with much lower efficiency (PubMed:18571493, PubMed:19056333). Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds (PubMed:18571493, PubMed:19056333). {ECO:0000269|PubMed:18571493, ECO:0000269|PubMed:19056333}.; FUNCTION: [Isoform 7]: No detected catalytic activity in vitro, possibly due to the lack of catalytic site. {ECO:0000269|PubMed:22227495}.; FUNCTION: [Isoform 8]: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds. Has a higher catalytic activity for xenobiotic alpha-dicarbonyl compounds, sucha as benzil, than isoform 1 and is involved in benzil detoxification. {ECO:0000269|PubMed:23128527}.	MISCELLANEOUS: Primate DHRS4s display different stereoselectivity and catalytic efficiency in the oxidoreduction of some substrates as compared to other mammal DHRS4s due to a difference in conserved amino acid residues (PubMed:18571493, PubMed:19056333). Three homologous proteins DHRS4, DHRS4L1, and DHRS4L2 are derived from gene duplication of DHRS4, and the gene cluster is arranged in tandem in chromosome 14 (PubMed:27323117). {ECO:0000269|PubMed:18571493, ECO:0000269|PubMed:19056333, ECO:0000269|PubMed:27323117}.	alcohol metabolic process [GO:0006066]; cellular ketone metabolic process [GO:0042180]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; retinal metabolic process [GO:0042574]; steroid metabolic process [GO:0008202]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	3-keto sterol reductase activity [GO:0000253]; 3beta-hydroxy-5beta-steroid dehydrogenase activity [GO:0033703]; alcohol dehydrogenase [NAD(P)+] activity [GO:0018455]; carbonyl reductase (NADPH) activity [GO:0004090]; identical protein binding [GO:0042802]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; 3-keto sterol reductase activity [GO:0000253]; 3beta-hydroxy-5beta-steroid dehydrogenase activity [GO:0033703]; alcohol dehydrogenase [NAD(P)+] activity [GO:0018455]; carbonyl reductase (NADPH) activity [GO:0004090]; identical protein binding [GO:0042802]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; alcohol metabolic process [GO:0006066]; cellular ketone metabolic process [GO:0042180]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; retinal metabolic process [GO:0042574]; steroid metabolic process [GO:0008202]	SUBCELLULAR LOCATION: [Isoform 1]: Peroxisome {ECO:0000269|PubMed:10333503, ECO:0000269|PubMed:17230527}. Note=Isoform 4 is not peroxisomal. {ECO:0000269|PubMed:17230527}.; SUBCELLULAR LOCATION: [Isoform 7]: Nucleus {ECO:0000269|PubMed:22227495}.
Q9BU02	reviewed	THTPA_HUMAN	Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28)	THTPA	Homo sapiens (Human)	230	FUNCTION: Hydrolase highly specific for thiamine triphosphate (ThTP). {ECO:0000269|PubMed:11827967, ECO:0000269|PubMed:23707715}.		dephosphorylation [GO:0016311]; generation of precursor metabolites and energy [GO:0006091]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine diphosphate metabolic process [GO:0042357]; thiamine metabolic process [GO:0006772]	cytosol [GO:0005829]	hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; thiamine triphosphate phosphatase activity [GO:0050333]	cytosol [GO:0005829]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; thiamine triphosphate phosphatase activity [GO:0050333]; dephosphorylation [GO:0016311]; generation of precursor metabolites and energy [GO:0006091]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine diphosphate metabolic process [GO:0042357]; thiamine metabolic process [GO:0006772]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11827967}.
Q9BU19	reviewed	ZN692_HUMAN	Zinc finger protein 692 (AICAR responsive element binding protein)	ZNF692 AREBP ZFP692	Homo sapiens (Human)	519	FUNCTION: May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. {ECO:0000269|PubMed:17097062, ECO:0000269|PubMed:21910974}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gluconeogenesis [GO:0006111]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gluconeogenesis [GO:0006111]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BU20	reviewed	CPLN2_HUMAN	Ciliogenesis and planar polarity effector 2 (REM2- and Rab-like small GTPase 1)	CPLANE2 C1orf89 RSG1	Homo sapiens (Human)	258	FUNCTION: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity). {ECO:0000250|UniProtKB:Q6GNL4}.		axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; cranial skeletal system development [GO:1904888]; endocardial cushion fusion [GO:0003274]; exocytosis [GO:0006887]; limb development [GO:0060173]; protein localization [GO:0008104]; protein processing [GO:0016485]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901620]; regulation of vesicle fusion [GO:0031338]; smoothened signaling pathway [GO:0007224]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; cranial skeletal system development [GO:1904888]; endocardial cushion fusion [GO:0003274]; exocytosis [GO:0006887]; limb development [GO:0060173]; protein localization [GO:0008104]; protein processing [GO:0016485]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901620]; regulation of vesicle fusion [GO:0031338]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q6GNL4}.
Q9BU40	reviewed	CRDL1_HUMAN	Chordin-like protein 1 (Neuralin-1) (Neurogenesin-1) (Ventroptin)	CHRDL1 NRLN1	Homo sapiens (Human)	456	FUNCTION: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. {ECO:0000250, ECO:0000269|PubMed:18587495, ECO:0000269|PubMed:22284829}.		AMPA glutamate receptor clustering [GO:0097113]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; embryonic axis specification [GO:0000578]; excitatory chemical synaptic transmission [GO:0098976]; eye development [GO:0001654]; negative regulation of BMP signaling pathway [GO:0030514]; ossification [GO:0001503]; regulation of synaptic plasticity [GO:0048167]; synapse maturation [GO:0060074]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; synapse [GO:0045202]	BMP binding [GO:0036122]; transforming growth factor beta binding [GO:0050431]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; synapse [GO:0045202]; BMP binding [GO:0036122]; transforming growth factor beta binding [GO:0050431]; AMPA glutamate receptor clustering [GO:0097113]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; embryonic axis specification [GO:0000578]; excitatory chemical synaptic transmission [GO:0098976]; eye development [GO:0001654]; negative regulation of BMP signaling pathway [GO:0030514]; ossification [GO:0001503]; regulation of synaptic plasticity [GO:0048167]; synapse maturation [GO:0060074]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BU61	reviewed	NDUF3_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3	NDUFAF3 C3orf60	Homo sapiens (Human)	184	FUNCTION: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). {ECO:0000269|PubMed:19463981}.		mitochondrial respiratory chain complex I assembly [GO:0032981]	mitochondrial inner membrane [GO:0005743]; nucleus [GO:0005634]		mitochondrial inner membrane [GO:0005743]; nucleus [GO:0005634]; mitochondrial respiratory chain complex I assembly [GO:0032981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Mitochondrion inner membrane {ECO:0000269|PubMed:19463981}.
Q9BU64	reviewed	CENPO_HUMAN	Centromere protein O (CENP-O) (Interphase centromere complex protein 36)	CENPO ICEN36 MCM21R	Homo sapiens (Human)	300	FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:16932742, ECO:0000269|PubMed:18007590}.		centromere complex assembly [GO:0034508]; chromosome segregation [GO:0007059]	cytosol [GO:0005829]; inner kinetochore [GO:0000939]; Mis6-Sim4 complex [GO:0031511]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; inner kinetochore [GO:0000939]; Mis6-Sim4 complex [GO:0031511]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; centromere complex assembly [GO:0034508]; chromosome segregation [GO:0007059]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Q9BU76	reviewed	MMTA2_HUMAN	Multiple myeloma tumor-associated protein 2 (hMMTAG2)	MMTAG2 C1orf35	Homo sapiens (Human)	263				extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]	RNA binding [GO:0003723]	extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; RNA binding [GO:0003723]	
Q9BU79	reviewed	TM243_HUMAN	Transmembrane protein 243 (MDR1- and mitochondrial taxol resistance-associated protein) (MM-TRAG)	TMEM243 C7orf23	Homo sapiens (Human)	118				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9BU89	reviewed	DOHH_HUMAN	Deoxyhypusine hydroxylase (hDOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (HEAT-like repeat-containing protein 1)	DOHH HLRC1	Homo sapiens (Human)	302	FUNCTION: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16533814, PubMed:16371467, PubMed:19706422). Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity). {ECO:0000250|UniProtKB:Q99LN9, ECO:0000255|HAMAP-Rule:MF_03101, ECO:0000269|PubMed:16371467, ECO:0000269|PubMed:16533814, ECO:0000269|PubMed:19706422}.		peptidyl-lysine modification to peptidyl-hypusine [GO:0008612]	cytosol [GO:0005829]	deoxyhypusine monooxygenase activity [GO:0019135]; iron ion binding [GO:0005506]	cytosol [GO:0005829]; deoxyhypusine monooxygenase activity [GO:0019135]; iron ion binding [GO:0005506]; peptidyl-lysine modification to peptidyl-hypusine [GO:0008612]	
Q9BUA3	reviewed	SPNDC_HUMAN	Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC)	SPINDOC C11orf84	Homo sapiens (Human)	381	FUNCTION: Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability (PubMed:29061846). Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway (PubMed:29061846). Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). {ECO:0000269|PubMed:29061846, ECO:0000269|PubMed:34737271}.		DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of protein ADP-ribosylation [GO:0010835]	nucleus [GO:0005634]; site of DNA damage [GO:0090734]		nucleus [GO:0005634]; site of DNA damage [GO:0090734]; DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of protein ADP-ribosylation [GO:0010835]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29061846}. Chromosome {ECO:0000269|PubMed:34737271}. Note=Colocalizes with PARP1 to sites of DNA damage. {ECO:0000269|PubMed:34737271}.
Q9BUB4	reviewed	ADAT1_HUMAN	tRNA-specific adenosine deaminase 1 (hADAT1) (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase)	ADAT1	Homo sapiens (Human)	502	FUNCTION: Specifically deaminates adenosine-37 to inosine in tRNA-Ala.		tRNA processing [GO:0008033]		metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251]; tRNA-specific adenosine-37 deaminase activity [GO:0043829]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251]; tRNA-specific adenosine-37 deaminase activity [GO:0043829]; tRNA processing [GO:0008033]	
Q9BUB5	reviewed	MKNK1_HUMAN	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1)	MKNK1 MNK1	Homo sapiens (Human)	465	FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}.		intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of translation [GO:0006417]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of translation [GO:0006417]	SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.
Q9BUB7	reviewed	TMM70_HUMAN	Transmembrane protein 70, mitochondrial	TMEM70	Homo sapiens (Human)	260	FUNCTION: Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (PubMed:31652072, PubMed:33753518, PubMed:33359711, PubMed:32275929). Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis (PubMed:33359711, PubMed:18953340, PubMed:20937241, PubMed:31652072). In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies (PubMed:32275929). {ECO:0000269|PubMed:18953340, ECO:0000269|PubMed:20937241, ECO:0000269|PubMed:31652072, ECO:0000269|PubMed:32275929, ECO:0000269|PubMed:33359711, ECO:0000269|PubMed:33753518}.		mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260]	mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	mitochondrial proton-transporting ATP synthase complex binding [GO:0140260]	mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; mitochondrial proton-transporting ATP synthase complex binding [GO:0140260]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:20937241, ECO:0000269|PubMed:24576557, ECO:0000269|PubMed:33359711}; Multi-pass membrane protein {ECO:0000269|PubMed:20937241, ECO:0000269|PubMed:24576557}. Note=Mostly located within the inner cristae membrane. {ECO:0000269|PubMed:33359711}.
Q9BUD6	reviewed	SPON2_HUMAN	Spondin-2 (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1) (Mindin)	SPON2 DIL1 UNQ435/PRO866	Homo sapiens (Human)	331	FUNCTION: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). {ECO:0000250}.		cell adhesion [GO:0007155]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to virus [GO:0051607]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; mast cell mediated immunity [GO:0002448]; opsonization [GO:0008228]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of tumor necrosis factor production [GO:0032760]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]	antigen binding [GO:0003823]; lipopolysaccharide binding [GO:0001530]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; antigen binding [GO:0003823]; lipopolysaccharide binding [GO:0001530]; metal ion binding [GO:0046872]; cell adhesion [GO:0007155]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to virus [GO:0051607]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; mast cell mediated immunity [GO:0002448]; opsonization [GO:0008228]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of tumor necrosis factor production [GO:0032760]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q9BUE0	reviewed	MED18_HUMAN	Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (p28b)	MED18	Homo sapiens (Human)	208	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.		positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; termination of RNA polymerase II transcription [GO:0006369]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BUE6	reviewed	ISCA1_HUMAN	Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA) (hIscA)	ISCA1 HBLD2 GK004	Homo sapiens (Human)	129	FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. {ECO:0000269|PubMed:15262227, ECO:0000269|PubMed:22323289}.		iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15262227, ECO:0000269|PubMed:22323289}.
Q9BUF5	reviewed	TBB6_HUMAN	Tubulin beta-6 chain (Tubulin beta class V)	TUBB6	Homo sapiens (Human)	446	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}.		microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q9BUF7	reviewed	CRUM3_HUMAN	Protein crumbs homolog 3	CRB3 UNQ588/PRO1158	Homo sapiens (Human)	120	FUNCTION: Involved in the establishment of cell polarity in mammalian epithelial cells (PubMed:12771187, PubMed:14718572). Regulates the morphogenesis of tight junctions (PubMed:12771187, PubMed:14718572). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:Q8QZT4, ECO:0000269|PubMed:12771187, ECO:0000269|PubMed:14718572}.		establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; positive regulation of cell junction assembly [GO:1901890]; protein localization to plasma membrane [GO:0072659]	apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; subapical complex [GO:0035003]	protein domain specific binding [GO:0019904]; SH3 domain binding [GO:0017124]	apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; subapical complex [GO:0035003]; protein domain specific binding [GO:0019904]; SH3 domain binding [GO:0017124]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; positive regulation of cell junction assembly [GO:1901890]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12527193, ECO:0000269|PubMed:12771187, ECO:0000269|PubMed:14718572}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:12527193}. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells. {ECO:0000269|PubMed:14718572}.
Q9BUH6	reviewed	PAXX_HUMAN	Protein PAXX (Paralog of XRCC4 and XLF) (XRCC4-like small protein)	PAXX C9orf142 XLS	Homo sapiens (Human)	204	FUNCTION: Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination (PubMed:25574025, PubMed:25670504, PubMed:25941166, PubMed:27705800). May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery (PubMed:25574025, PubMed:25670504, PubMed:25941166). Involved in NHEJ by promoting the ligation of blunt-ended DNA ends (PubMed:27703001). Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:30250067, PubMed:25670504). Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair (PubMed:27705800). Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism (PubMed:29144403). {ECO:0000269|PubMed:25574025, ECO:0000269|PubMed:25670504, ECO:0000269|PubMed:25941166, ECO:0000269|PubMed:27703001, ECO:0000269|PubMed:27705800, ECO:0000269|PubMed:29144403, ECO:0000269|PubMed:30250067}.		DNA damage response [GO:0006974]; double-strand break repair via nonhomologous end joining [GO:0006303]	cytoplasm [GO:0005737]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	DNA polymerase binding [GO:0070182]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; DNA polymerase binding [GO:0070182]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; DNA damage response [GO:0006974]; double-strand break repair via nonhomologous end joining [GO:0006303]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25574025, ECO:0000269|PubMed:25670504, ECO:0000269|PubMed:29144403}. Chromosome {ECO:0000269|PubMed:25574025, ECO:0000269|PubMed:25670504}. Note=Predominantly localizes to the nucleus. Accumulates at sites of DNA damage generated by laser microirradiation. {ECO:0000269|PubMed:25574025, ECO:0000269|PubMed:25670504}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29144403}. Note=(Microbial infection) Upon infection by herpesvirus 1 (HSV-1), it is partially translocated into the cytoplasm in an HSV-1-dependent manner. {ECO:0000269|PubMed:29144403}.
Q9BUH8	reviewed	BEGIN_HUMAN	Brain-enriched guanylate kinase-associated protein	BEGAIN KIAA1446	Homo sapiens (Human)	593	FUNCTION: May sustain the structure of the postsynaptic density (PSD).			cytoplasm [GO:0005737]; membrane [GO:0016020]; synapse [GO:0045202]		cytoplasm [GO:0005737]; membrane [GO:0016020]; synapse [GO:0045202]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q9BUI4	reviewed	RPC3_HUMAN	DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) (RNA polymerase III 62 kDa subunit) (RPC62)	POLR3C	Homo sapiens (Human)	534	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628). {ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:21358628}.	MISCELLANEOUS: Antibodies against POLR3C have been found in the sera of patients with systemic sclerosis (SSc).	defense response to virus [GO:0051607]; DNA-templated transcription [GO:0006351]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]	DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; single-stranded DNA binding [GO:0003697]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; single-stranded DNA binding [GO:0003697]; defense response to virus [GO:0051607]; DNA-templated transcription [GO:0006351]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9BUJ2	reviewed	HNRL1_HUMAN	Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5)	HNRNPUL1 E1BAP5 HNRPUL1	Homo sapiens (Human)	856	FUNCTION: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}.	MISCELLANEOUS: Its methylation is enhanced in the late phase of adenoviral infection.; MISCELLANEOUS: [Isoform 5]: May be due to intron retention. {ECO:0000305}.	response to virus [GO:0009615]; RNA processing [GO:0006396]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]	enzyme binding [GO:0019899]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]; enzyme binding [GO:0019899]; RNA binding [GO:0003723]; response to virus [GO:0009615]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11513728, ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}.
Q9BUK6	reviewed	MSTO1_HUMAN	Protein misato homolog 1	MSTO1 LST005 SLTP005	Homo sapiens (Human)	570	FUNCTION: Involved in the regulation of mitochondrial distribution and morphology (PubMed:17349998, PubMed:28554942, PubMed:28544275). Required for mitochondrial fusion and mitochondrial network formation (PubMed:28554942, PubMed:28544275). {ECO:0000269|PubMed:17349998, ECO:0000269|PubMed:28544275, ECO:0000269|PubMed:28554942}.		mitochondrion distribution [GO:0048311]; mitochondrion organization [GO:0007005]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; mitochondrion distribution [GO:0048311]; mitochondrion organization [GO:0007005]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:17349998, ECO:0000269|PubMed:28554942}. Cytoplasm {ECO:0000269|PubMed:28544275, ECO:0000269|PubMed:28554942}.
Q9BUL5	reviewed	PHF23_HUMAN	PHD finger protein 23 (PDH-containing protein JUNE-1)	PHF23	Homo sapiens (Human)	403	FUNCTION: Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. {ECO:0000269|PubMed:25484098}.		autophagy [GO:0006914]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of autophagosome maturation [GO:1901097]; positive regulation of protein ubiquitination [GO:0031398]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; autophagy [GO:0006914]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of autophagosome maturation [GO:1901097]; positive regulation of protein ubiquitination [GO:0031398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25484098}. Cytoplasm {ECO:0000269|PubMed:25484098}. Note=Mainly present in the nucleus and part in the cytoplasm. {ECO:0000269|PubMed:25484098}.
Q9BUL8	reviewed	PDC10_HUMAN	Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15)	PDCD10 CCM3 TFAR15	Homo sapiens (Human)	212	FUNCTION: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). {ECO:0000250|UniProtKB:Q8VE70, ECO:0000269|PubMed:15543491, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:20332113, ECO:0000269|PubMed:27807006}.		angiogenesis [GO:0001525]; cellular response to leukemia inhibitory factor [GO:1990830]; endothelium development [GO:0003158]; establishment of Golgi localization [GO:0051683]; Golgi reassembly [GO:0090168]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of gene expression [GO:0010629]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein stabilization [GO:0050821]; regulation of angiogenesis [GO:0045765]; regulation of Golgi organization [GO:1903358]; stress-activated protein kinase signaling cascade [GO:0031098]; wound healing, spreading of cells [GO:0044319]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; angiogenesis [GO:0001525]; cellular response to leukemia inhibitory factor [GO:1990830]; endothelium development [GO:0003158]; establishment of Golgi localization [GO:0051683]; Golgi reassembly [GO:0090168]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of gene expression [GO:0010629]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein stabilization [GO:0050821]; regulation of angiogenesis [GO:0045765]; regulation of Golgi organization [GO:1903358]; stress-activated protein kinase signaling cascade [GO:0031098]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially co-localizes with endogenous PXN at the leading edges of migrating cells.
Q9BUL9	reviewed	RPP25_HUMAN	Ribonuclease P protein subunit p25 (RNase P protein subunit p25)	RPP25	Homo sapiens (Human)	199	FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:12003489, PubMed:16723659, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:12003489, ECO:0000269|PubMed:16723659, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648}.		rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]	centriolar satellite [GO:0034451]; multimeric ribonuclease P complex [GO:0030681]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]	ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723]	centriolar satellite [GO:0034451]; multimeric ribonuclease P complex [GO:0030681]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]; ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723]; rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12003489, ECO:0000269|PubMed:20215441}.
Q9BUM1	reviewed	G6PC3_HUMAN	Glucose-6-phosphatase 3 (G-6-Pase 3) (G6Pase 3) (EC 3.1.3.9) (Glucose-6-phosphatase beta) (G6Pase-beta) (Ubiquitous glucose-6-phosphatase catalytic subunit-related protein)	G6PC3 UGRP	Homo sapiens (Human)	346	FUNCTION: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function. {ECO:0000269|PubMed:12370122, ECO:0000269|PubMed:12965222, ECO:0000269|PubMed:13129915}.		gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose-6-phosphate transport [GO:0015760]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	glucose-6-phosphatase activity [GO:0004346]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; glucose-6-phosphatase activity [GO:0004346]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose-6-phosphate transport [GO:0015760]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:13129915}; Multi-pass membrane protein {ECO:0000269|PubMed:13129915}.
Q9BUN5	reviewed	CC28B_HUMAN	Coiled-coil domain-containing protein 28B	CCDC28B	Homo sapiens (Human)	200	FUNCTION: Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex. {ECO:0000269|PubMed:23015189, ECO:0000269|PubMed:23727834}.		cilium assembly [GO:0060271]	centrosome [GO:0005813]; cytoplasm [GO:0005737]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16327777}. Note=It localizes near centrosomes and basal bodies.
Q9BUN8	reviewed	DERL1_HUMAN	Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)	DERL1 DER1 UNQ243/PRO276	Homo sapiens (Human)	251	FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins (PubMed:15215856, PubMed:33658201). Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane (PubMed:33658201). This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (PubMed:33658201). The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first (PubMed:33658201). May mediate the interaction between VCP and the misfolded protein (PubMed:15215856). Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000269|PubMed:15215856, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:33658201}.; FUNCTION: (Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:15215856}.		endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated misfolded protein catabolic process [GO:0071712]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; positive regulation of protein binding [GO:0032092]; positive regulation of protein ubiquitination [GO:0031398]; protein destabilization [GO:0031648]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]	Derlin-1 retrotranslocation complex [GO:0036513]; Derlin-1-VIMP complex [GO:0036502]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; late endosome [GO:0005770]; membrane [GO:0016020]	ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; MHC class I protein binding [GO:0042288]; misfolded protein binding [GO:0051787]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; signal recognition particle binding [GO:0005047]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-specific protease binding [GO:1990381]	Derlin-1 retrotranslocation complex [GO:0036513]; Derlin-1-VIMP complex [GO:0036502]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; late endosome [GO:0005770]; membrane [GO:0016020]; ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; MHC class I protein binding [GO:0042288]; misfolded protein binding [GO:0051787]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; signal recognition particle binding [GO:0005047]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-specific protease binding [GO:1990381]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated misfolded protein catabolic process [GO:0071712]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; positive regulation of protein binding [GO:0032092]; positive regulation of protein ubiquitination [GO:0031398]; protein destabilization [GO:0031648]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:15215856, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189}; Multi-pass membrane protein {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:15215856, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189}.
Q9BUP0	reviewed	EFHD1_HUMAN	EF-hand domain-containing protein D1 (EF-hand domain-containing protein 1) (Swiprosin-2)	EFHD1 SWS2 PP3051	Homo sapiens (Human)	239	FUNCTION: Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (PubMed:26975899). May play a role in neuronal differentiation (By similarity). {ECO:0000250|UniProtKB:Q9D4J1, ECO:0000269|PubMed:26975899}.		neuron projection development [GO:0031175]; regulation of cellular hyperosmotic salinity response [GO:1900069]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	calcium ion sensor activity [GO:0061891]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; calcium ion sensor activity [GO:0061891]; neuron projection development [GO:0031175]; regulation of cellular hyperosmotic salinity response [GO:1900069]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9D4J1}.
Q9BUP3	reviewed	HTAI2_HUMAN	Oxidoreductase HTATIP2 (EC 1.1.1.-) (30 kDa HIV-1 TAT-interacting protein) (HIV-1 TAT-interactive protein 2)	HTATIP2 CC3 TIP30	Homo sapiens (Human)	242	FUNCTION: Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. {ECO:0000269|PubMed:10611237, ECO:0000269|PubMed:11313954, ECO:0000269|PubMed:15282309, ECO:0000269|PubMed:9174052}.	MISCELLANEOUS: [Isoform 2]: Mutagenesis of Leu-154 and Leu-157 or Cys-158, Cys-160 and Cys-161 abolishes antiapoptotic effect. {ECO:0000305}.	angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; import into nucleus [GO:0051170]; negative regulation of apoptotic process [GO:0043066]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; regulation of angiogenesis [GO:0045765]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]	oxidoreductase activity [GO:0016491]; protein serine/threonine kinase activity [GO:0004674]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; oxidoreductase activity [GO:0016491]; protein serine/threonine kinase activity [GO:0004674]; transcription coactivator activity [GO:0003713]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; import into nucleus [GO:0051170]; negative regulation of apoptotic process [GO:0043066]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; regulation of angiogenesis [GO:0045765]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15282309}. Nucleus envelope {ECO:0000269|PubMed:15282309}.
Q9BUQ8	reviewed	DDX23_HUMAN	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD)	DDX23	Homo sapiens (Human)	820	FUNCTION: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). {ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:28076779}.		cis assembly of pre-catalytic spliceosome [GO:0000354]; mRNA splicing, via spliceosome [GO:0000398]; R-loop processing [GO:0062176]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	catalytic step 2 spliceosome [GO:0071013]; chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	catalytic step 2 spliceosome [GO:0071013]; chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; cis assembly of pre-catalytic spliceosome [GO:0000354]; mRNA splicing, via spliceosome [GO:0000398]; R-loop processing [GO:0062176]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9409622}. Chromosome {ECO:0000269|PubMed:28076779}. Note=During transcription, accumulates at chromatin loci where unscheduled R-loops form and colocalizes with paused 'Ser-5'-phosphorlyated POLR2A/RNA polymerase II and kinase SRPK2. {ECO:0000269|PubMed:28076779}.
Q9BUR4	reviewed	TCAB1_HUMAN	Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta)	WRAP53 TCAB1 WDR79	Homo sapiens (Human)	548	FUNCTION: RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29804836, PubMed:29695869). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29804836, PubMed:29695869). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}.	MISCELLANEOUS: The mRNA encoding this protein plays a critical role in the regulation of p53/TP53 expression at the post-transcriptional level; it is involved both in maintaining basal p53/TP53 mRNA levels and in p53/TP53 induction upon DNA damage. {ECO:0000269|PubMed:19250907}.	Cajal body organization [GO:0030576]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of telomerase activity [GO:0051973]; protein localization to Cajal body [GO:1904867]; RNA folding [GO:0034337]; scaRNA localization to Cajal body [GO:0090666]; telomerase RNA localization to Cajal body [GO:0090671]; telomere formation via telomerase [GO:0032203]; telomere maintenance via telomerase [GO:0007004]	Cajal body [GO:0015030]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; telomerase holoenzyme complex [GO:0005697]	histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; ubiquitin protein ligase binding [GO:0031625]	Cajal body [GO:0015030]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; telomerase holoenzyme complex [GO:0005697]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; ubiquitin protein ligase binding [GO:0031625]; Cajal body organization [GO:0030576]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of telomerase activity [GO:0051973]; protein localization to Cajal body [GO:1904867]; RNA folding [GO:0034337]; scaRNA localization to Cajal body [GO:0090666]; telomerase RNA localization to Cajal body [GO:0090671]; telomere formation via telomerase [GO:0032203]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Nucleus, Cajal body {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:24318571, ECO:0000269|PubMed:26170453}. Chromosome, telomere {ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:29804836}. Chromosome {ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26734725, ECO:0000269|PubMed:27715493}. Note=Released from telomerase RNA template component (TERC) in mitotic cells coincident with delocalization from Cajal bodies (PubMed:26170453). In response to DNA damage, localizes to sites of DNA double-strand breaks following phosphorylation by ATM (PubMed:26734725, PubMed:27715493). {ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:26734725, ECO:0000269|PubMed:27715493}.
Q9BUR5	reviewed	MIC26_HUMAN	MICOS complex subunit MIC26 (Apolipoprotein O) (MICOS complex subunit MIC23) (Protein FAM121B)	APOO FAM121B MIC23 MIC26 My025 UNQ1866/PRO4302	Homo sapiens (Human)	198	FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892). {ECO:0000269|PubMed:16956892, ECO:0000269|PubMed:24743151, ECO:0000269|PubMed:25764979}.		cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; lipid transport [GO:0006869]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]; very-low-density lipoprotein particle [GO:0034361]		cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]; very-low-density lipoprotein particle [GO:0034361]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:25764979}; Single-pass membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:16956892, ECO:0000269|PubMed:25764979}. Mitochondrion {ECO:0000269|PubMed:25781180}. Golgi apparatus membrane {ECO:0000269|PubMed:25764979}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25764979}. Note=Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form. {ECO:0000269|PubMed:25764979}.
Q9BUT1	reviewed	DHRS6_HUMAN	Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.-) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (EC 1.1.1.30) (4-oxo-L-proline reductase) (EC 1.1.1.104) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1)	BDH2 DHRS6 SDR15C1 UNQ6308/PRO20933	Homo sapiens (Human)	245	FUNCTION: NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (PubMed:35150746) (By similarity). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (PubMed:35150746). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372). {ECO:0000250|UniProtKB:Q8JZV9, ECO:0000269|PubMed:16380372, ECO:0000269|PubMed:35150746}.		epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; heme metabolic process [GO:0042168]; intracellular sequestering of iron ion [GO:0006880]; siderophore biosynthetic process [GO:0019290]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	3-hydroxybutyrate dehydrogenase activity [GO:0003858]; 4-oxoproline reductase activity [GO:0016617]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 3-hydroxybutyrate dehydrogenase activity [GO:0003858]; 4-oxoproline reductase activity [GO:0016617]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; heme metabolic process [GO:0042168]; intracellular sequestering of iron ion [GO:0006880]; siderophore biosynthetic process [GO:0019290]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16380372}.
Q9BUU2	reviewed	MET22_HUMAN	Methyltransferase-like protein 22 (EC 2.1.1.-)	METTL22 C16orf68 LP8272	Homo sapiens (Human)	404	FUNCTION: Protein N-lysine methyltransferase. Trimethylates KIN at Lys-135 (in vitro). {ECO:0000269|PubMed:23349634}.		protein methylation [GO:0006479]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	heat shock protein binding [GO:0031072]; histone methyltransferase activity [GO:0042054]; protein methyltransferase activity [GO:0008276]; protein-lysine N-methyltransferase activity [GO:0016279]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; heat shock protein binding [GO:0031072]; histone methyltransferase activity [GO:0042054]; protein methyltransferase activity [GO:0008276]; protein-lysine N-methyltransferase activity [GO:0016279]; protein methylation [GO:0006479]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23349634}.
Q9BUV0	reviewed	RSRP1_HUMAN	Arginine/serine-rich protein 1	RSRP1 C1orf63 HT033 NPD014	Homo sapiens (Human)	290	FUNCTION: Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6. {ECO:0000269|PubMed:34042961}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	spliceosomal complex assembly [GO:0000245]	nucleus [GO:0005634]		nucleus [GO:0005634]; spliceosomal complex assembly [GO:0000245]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34042961}.
Q9BUV8	reviewed	RCAF1_HUMAN	GEL complex subunit OPTI (Obligate partner of TMCO1 insertase) (Rab5-interacting protein) (RIP5) (Respirasome Complex Assembly Factor 1)	RAB5IF C20orf24 OPTI RCAF1 PNAS-11	Homo sapiens (Human)	137	FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (PubMed:36261522). In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes (PubMed:31536960). {ECO:0000269|PubMed:31536960, ECO:0000269|PubMed:36261522}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mitochondrial respirasome assembly [GO:0097250]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]	endoplasmic reticulum membrane [GO:0005789]; mitochondrial respirasome [GO:0005746]; multi-pass translocon complex [GO:0160064]		endoplasmic reticulum membrane [GO:0005789]; mitochondrial respirasome [GO:0005746]; multi-pass translocon complex [GO:0160064]; mitochondrial respirasome assembly [GO:0097250]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:36261522}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:31536960}; Multi-pass membrane protein {ECO:0000255}.
Q9BUW7	reviewed	BBLN_HUMAN	Bublin coiled-coil protein (UPF0184 protein C9orf16)	BBLN C9orf16 EST00098	Homo sapiens (Human)	83	FUNCTION: Essential for intermediate filament organization in intestinal cells, interacts with intermediate filament and regulates intestinal lumen morphology. {ECO:0000269|PubMed:33857431}.		intermediate filament bundle assembly [GO:0045110]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; subapical part of cell [GO:0120219]	molecular adaptor activity [GO:0060090]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; subapical part of cell [GO:0120219]; molecular adaptor activity [GO:0060090]; intermediate filament bundle assembly [GO:0045110]	SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:33857431}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:33857431}. Note=In the intestine, localizes subapically and at cell junctions. Interacts with intermediate filament (IF) proteins and localizes to the IF network in an IF-dependent manner (PubMed:33857431). In dividing cells, localizes to interpolar and kinetochore microtubules (PubMed:33857431). {ECO:0000269|PubMed:33857431}.
Q9BUX1	reviewed	CHAC1_HUMAN	Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 4.3.2.7) (Blocks Notch protein) (Botch) (Cation transport regulator-like protein 1)	CHAC1 BOTCH	Homo sapiens (Human)	222	FUNCTION: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). {ECO:0000269|PubMed:19109178, ECO:0000269|PubMed:22445366, ECO:0000269|PubMed:27913623}.		glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein processing [GO:0010955]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; response to unfolded protein [GO:0006986]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; trans-Golgi network [GO:0005802]	gamma-glutamylcyclotransferase activity [GO:0003839]; glutathione specific gamma-glutamylcyclotransferase activity [GO:0061928]; Notch binding [GO:0005112]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; trans-Golgi network [GO:0005802]; gamma-glutamylcyclotransferase activity [GO:0003839]; glutathione specific gamma-glutamylcyclotransferase activity [GO:0061928]; Notch binding [GO:0005112]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein processing [GO:0010955]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19109178}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8R3J5}.
Q9BUY5	reviewed	ZN426_HUMAN	Zinc finger protein 426	ZNF426	Homo sapiens (Human)	554	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BUZ4	reviewed	TRAF4_HUMAN	TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)	TRAF4 CART1 MLN62 RNF83	Homo sapiens (Human)	470	FUNCTION: Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed:31076633, PubMed:32268273, PubMed:33991522). Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed:30352854). Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed:31076633). Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed:32357935). In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed:33991522). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed:32268273). {ECO:0000250, ECO:0000269|PubMed:12023963, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:16052631, ECO:0000269|PubMed:16157600, ECO:0000269|PubMed:18953416, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:30352854, ECO:0000269|PubMed:31076633, ECO:0000269|PubMed:32268273, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33991522}.		apoptotic process [GO:0006915]; innate immune response [GO:0045087]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein kinase activity [GO:0045860]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; respiratory gaseous exchange by respiratory system [GO:0007585]; respiratory tube development [GO:0030323]; signal transduction [GO:0007165]	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996]; transferase activity [GO:0016740]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270]	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996]; transferase activity [GO:0016740]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; innate immune response [GO:0045087]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein kinase activity [GO:0045860]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; respiratory gaseous exchange by respiratory system [GO:0007585]; respiratory tube development [GO:0030323]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:32268273}. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton {ECO:0000305}.
Q9BV10	reviewed	ALG12_HUMAN	Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12 homolog) (hALG12) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Mannosyltransferase ALG12 homolog) (Membrane protein SB87)	ALG12 PP14673	Homo sapiens (Human)	488	FUNCTION: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein folding [GO:0006457]; protein N-linked glycosylation [GO:0006487]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	alpha-1,6-mannosyltransferase activity [GO:0000009]; dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase [GO:0052917]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; alpha-1,6-mannosyltransferase activity [GO:0000009]; dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase [GO:0052917]; mannosyltransferase activity [GO:0000030]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein folding [GO:0006457]; protein N-linked glycosylation [GO:0006487]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9BV20	reviewed	MTNA_HUMAN	Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (Mediator of RhoA-dependent invasion) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein)	MRI1 MRDI UNQ6390/PRO21135	Homo sapiens (Human)	369	FUNCTION: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. {ECO:0000255|HAMAP-Rule:MF_03119, ECO:0000269|PubMed:19620624}.		L-methionine salvage from methylthioadenosine [GO:0019509]; L-methionine salvage from S-adenosylmethionine [GO:0019284]	cell projection [GO:0042995]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]; S-methyl-5-thioribose-1-phosphate isomerase activity [GO:0046523]	cell projection [GO:0042995]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; S-methyl-5-thioribose-1-phosphate isomerase activity [GO:0046523]; L-methionine salvage from methylthioadenosine [GO:0019509]; L-methionine salvage from S-adenosylmethionine [GO:0019284]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03119, ECO:0000269|PubMed:19620624}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03119, ECO:0000269|PubMed:19620624}. Cell projection {ECO:0000269|PubMed:19620624}. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.
Q9BV23	reviewed	ABHD6_HUMAN	Monoacylglycerol lipase ABHD6 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 6)	ABHD6	Homo sapiens (Human)	337	FUNCTION: Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015). {ECO:0000250|UniProtKB:Q8R2Y0, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:26491015}.		acylglycerol catabolic process [GO:0046464]; arachidonic acid metabolic process [GO:0019369]; long-term synaptic depression [GO:0060292]; lysobisphosphatidic acid metabolic process [GO:2001311]; monoacylglycerol catabolic process [GO:0052651]; negative regulation of cell migration [GO:0030336]; negative regulation of cold-induced thermogenesis [GO:0120163]; phospholipid catabolic process [GO:0009395]; positive regulation of lipid biosynthetic process [GO:0046889]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]	AMPA glutamate receptor complex [GO:0032281]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	acylglycerol lipase activity [GO:0047372]; phospholipase activity [GO:0004620]	AMPA glutamate receptor complex [GO:0032281]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; acylglycerol lipase activity [GO:0047372]; phospholipase activity [GO:0004620]; acylglycerol catabolic process [GO:0046464]; arachidonic acid metabolic process [GO:0019369]; long-term synaptic depression [GO:0060292]; lysobisphosphatidic acid metabolic process [GO:2001311]; monoacylglycerol catabolic process [GO:0052651]; negative regulation of cell migration [GO:0030336]; negative regulation of cold-induced thermogenesis [GO:0120163]; phospholipid catabolic process [GO:0009395]; positive regulation of lipid biosynthetic process [GO:0046889]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q8R2Y0}; Single-pass type II membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8R2Y0}; Single-pass type II membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q8R2Y0}; Single-pass type II membrane protein {ECO:0000255}.
Q9BV29	reviewed	CCD32_HUMAN	Coiled-coil domain-containing protein 32	CCDC32 C15orf57	Homo sapiens (Human)	185	FUNCTION: Regulates clathrin-mediated endocytsois of cargos such as transferrin probably through the association and modulation of adaptor protein complex 2 (AP-2) (PubMed:33859415). Has a role in ciliogenesis (By similarity). Required for proper cephalic and left/right axis development (PubMed:32307552). {ECO:0000250|UniProtKB:X1WGV5, ECO:0000269|PubMed:32307552, ECO:0000269|PubMed:33859415}.		cilium organization [GO:0044782]; head development [GO:0060322]; regulation of clathrin-dependent endocytosis [GO:2000369]	clathrin-coated pit [GO:0005905]		clathrin-coated pit [GO:0005905]; cilium organization [GO:0044782]; head development [GO:0060322]; regulation of clathrin-dependent endocytosis [GO:2000369]	SUBCELLULAR LOCATION: Membrane, coated pit {ECO:0000269|PubMed:33859415}; Peripheral membrane protein {ECO:0000305|PubMed:33859415}; Cytoplasmic side {ECO:0000305|PubMed:33859415}.
Q9BV35	reviewed	SCMC3_HUMAN	Mitochondrial adenyl nucleotide antiporter SLC25A23 (Mitochondrial ATP-Mg/Pi carrier protein 2) (Short calcium-binding mitochondrial carrier protein 3) (SCaMC-3) (Solute carrier family 25 member 23)	SLC25A23 APC2 MCSC2 SCAMC3	Homo sapiens (Human)	468	FUNCTION: Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways (PubMed:15123600). Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP (PubMed:24430870, PubMed:28695448). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600). {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:24430870, ECO:0000269|PubMed:28695448}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	adenine nucleotide transport [GO:0051503]; ADP transport [GO:0015866]; ATP transport [GO:0015867]; calcium import into the mitochondrion [GO:0036444]; cellular response to calcium ion [GO:0071277]; mitochondrial ATP transmembrane transport [GO:1990544]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; regulation of cellular hyperosmotic salinity response [GO:1900069]; regulation of oxidative phosphorylation [GO:0002082]; regulation of sequestering of calcium ion [GO:0051282]; renal system process [GO:0003014]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	adenine nucleotide transmembrane transporter activity [GO:0000295]; ADP:inorganic phosphate antiporter activity [GO:0140988]; ATP transmembrane transporter activity [GO:0005347]; ATP:inorganic phosphate antiporter activity [GO:0140987]; calcium ion binding [GO:0005509]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; adenine nucleotide transmembrane transporter activity [GO:0000295]; ADP:inorganic phosphate antiporter activity [GO:0140988]; ATP transmembrane transporter activity [GO:0005347]; ATP:inorganic phosphate antiporter activity [GO:0140987]; calcium ion binding [GO:0005509]; adenine nucleotide transport [GO:0051503]; ADP transport [GO:0015866]; ATP transport [GO:0015867]; calcium import into the mitochondrion [GO:0036444]; cellular response to calcium ion [GO:0071277]; mitochondrial ATP transmembrane transport [GO:1990544]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; regulation of cellular hyperosmotic salinity response [GO:1900069]; regulation of oxidative phosphorylation [GO:0002082]; regulation of sequestering of calcium ion [GO:0051282]; renal system process [GO:0003014]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:15054102, ECO:0000305|PubMed:15123600, ECO:0000305|PubMed:15716113}; Multi-pass membrane protein {ECO:0000255}.
Q9BV36	reviewed	MELPH_HUMAN	Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a)	MLPH SLAC2A	Homo sapiens (Human)	600	FUNCTION: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}.		intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]	cortical actin cytoskeleton [GO:0030864]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]	actin binding [GO:0003779]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]	cortical actin cytoskeleton [GO:0030864]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; actin binding [GO:0003779]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]	SUBCELLULAR LOCATION: Cytoplasm.
Q9BV38	reviewed	WDR18_HUMAN	WD repeat-containing protein 18	WDR18	Homo sapiens (Human)	432	FUNCTION: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). May play a role during development (By similarity). {ECO:0000250|UniProtKB:Q68EI0, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}.		DNA-templated DNA replication [GO:0006261]; rRNA processing [GO:0006364]	dynein axonemal particle [GO:0120293]; nuclear pre-replicative complex [GO:0005656]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Rix1 complex [GO:0097344]		dynein axonemal particle [GO:0120293]; nuclear pre-replicative complex [GO:0005656]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Rix1 complex [GO:0097344]; DNA-templated DNA replication [GO:0006261]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21326211}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q4VBE8}. Cytoplasm {ECO:0000250|UniProtKB:Q4VBE8}. Dynein axonemal particle {ECO:0000250|UniProtKB:A0A1L8HX76}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250|UniProtKB:Q4VBE8}.
Q9BV40	reviewed	VAMP8_HUMAN	Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)	VAMP8	Homo sapiens (Human)	100	FUNCTION: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Also plays a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity). Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (PubMed:31694946). {ECO:0000250|UniProtKB:Q9WUF4, ECO:0000269|PubMed:12130530, ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686604, ECO:0000269|PubMed:31694946}.		autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; defense response to virus [GO:0051607]; mucus secretion [GO:0070254]; negative regulation of secretion by cell [GO:1903531]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031]; regulation of protein localization to plasma membrane [GO:1903076]; SNARE complex assembly [GO:0035493]; vesicle fusion [GO:0006906]; viral entry into host cell [GO:0046718]	azurophil granule membrane [GO:0035577]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mucin granule [GO:0098594]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; SNARE complex [GO:0031201]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; vesicle [GO:0031982]	chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]	azurophil granule membrane [GO:0035577]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mucin granule [GO:0098594]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; SNARE complex [GO:0031201]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; vesicle [GO:0031982]; chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]; autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; defense response to virus [GO:0051607]; mucus secretion [GO:0070254]; negative regulation of secretion by cell [GO:1903531]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031]; regulation of protein localization to plasma membrane [GO:1903076]; SNARE complex assembly [GO:0035493]; vesicle fusion [GO:0006906]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:25686604}; Single-pass type IV membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:25648148, ECO:0000269|PubMed:9614193}; Single-pass type IV membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:25648148}; Single-pass type IV membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:O70404}; Single-pass type IV membrane protein {ECO:0000305}. Zymogen granule membrane {ECO:0000250|UniProtKB:O70404}; Single-pass type IV membrane protein {ECO:0000305}. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (By similarity). Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell (By similarity). Cycles through the apical but not through the basolateral plasma membrane (By similarity). Apical region of acinar cells; in zymogen granule membranes (By similarity). {ECO:0000250|UniProtKB:Q9WUF4}.
Q9BV44	reviewed	THUM3_HUMAN	tRNA (guanine(6)-N2)-methyltransferase THUMP3 (EC 2.1.1.256) (THUMP domain-containing protein 3)	THUMPD3	Homo sapiens (Human)	507	FUNCTION: Methyltransferase which catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates containing the characteristic 3'-CCA terminus of mature tRNAs (PubMed:34669960). Also catalyzes the formation of N(2)-methylguanosine at position 7 of tRNA(Trp) (PubMed:34669960). Requires the methyltransferase adapter protein TRM112 for tRNA methyltransferase activity (PubMed:34669960). {ECO:0000269|PubMed:34669960}.		tRNA methylation [GO:0030488]; tRNA N2-guanine methylation [GO:0002940]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]	tRNA (guanine) methyltransferase activity [GO:0016423]; tRNA (guanine-N2-)-methyltransferase activity [GO:0004809]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; tRNA (guanine) methyltransferase activity [GO:0016423]; tRNA (guanine-N2-)-methyltransferase activity [GO:0004809]; tRNA binding [GO:0000049]; tRNA methylation [GO:0030488]; tRNA N2-guanine methylation [GO:0002940]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34669960, ECO:0000269|PubMed:34948388}.
Q9BV47	reviewed	DUS26_HUMAN	Dual specificity protein phosphatase 26 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase SKRP3) (Low-molecular-mass dual-specificity phosphatase 4) (DSP-4) (LDP-4) (Mitogen-activated protein kinase phosphatase 8) (MAP kinase phosphatase 8) (MKP-8) (Novel amplified gene in thyroid anaplastic cancer)	DUSP26 DUSP24 LDP4 MKP8 NATA1 SKRP3	Homo sapiens (Human)	211	FUNCTION: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). {ECO:0000269|PubMed:15796912, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:16924234, ECO:0000269|PubMed:17001450}.		negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell adhesion [GO:0045785]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	MAP kinase phosphatase activity [GO:0033549]; myosin phosphatase activity [GO:0017018]; p53 binding [GO:0002039]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; MAP kinase phosphatase activity [GO:0033549]; myosin phosphatase activity [GO:0017018]; p53 binding [GO:0002039]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell adhesion [GO:0045785]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Golgi apparatus.
Q9BV57	reviewed	MTND_HUMAN	Acireductone dioxygenase (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD') (Fe-ARD) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring)) (ARD) (Ni-ARD) (EC 1.13.11.53) (Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1) (MTCBP-1) (Submergence-induced protein-like factor) (Sip-L)	ADI1 MTCBP1 HMFT1638	Homo sapiens (Human)	179	FUNCTION: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway (PubMed:15938715). Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity). Also down-regulates cell migration mediated by MMP14 (PubMed:14718544). Necessary for hepatitis C virus replication in an otherwise non-permissive cell line (PubMed:11602742). {ECO:0000255|HAMAP-Rule:MF_03154, ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:14718544, ECO:0000269|PubMed:15938715}.		L-methionine salvage from methylthioadenosine [GO:0019509]; methionine metabolic process [GO:0006555]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	acireductone dioxygenase (Ni2+-requiring) activity [GO:0010308]; acireductone dioxygenase [iron(II)-requiring] activity [GO:0010309]; iron ion binding [GO:0005506]; nickel cation binding [GO:0016151]; oxidoreductase activity [GO:0016491]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; acireductone dioxygenase (Ni2+-requiring) activity [GO:0010308]; acireductone dioxygenase [iron(II)-requiring] activity [GO:0010309]; iron ion binding [GO:0005506]; nickel cation binding [GO:0016151]; oxidoreductase activity [GO:0016491]; L-methionine salvage from methylthioadenosine [GO:0019509]; methionine metabolic process [GO:0006555]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000303|PubMed:14718544}. Nucleus {ECO:0000303|PubMed:14718544}. Cell membrane {ECO:0000303|PubMed:14718544}; Peripheral membrane protein {ECO:0000303|PubMed:14718544}; Cytoplasmic side {ECO:0000303|PubMed:14718544}. Note=Localizes to the plasma membrane when complexed to MMP14. {ECO:0000303|PubMed:14718544}.
Q9BV68	reviewed	RN126_HUMAN	E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126)	RNF126	Homo sapiens (Human)	311	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174). Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174, PubMed:29042515). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564). {ECO:0000250|UniProtKB:Q91YL2, ECO:0000269|PubMed:23277564, ECO:0000269|PubMed:23418353, ECO:0000269|PubMed:24275455, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:29042515, ECO:0000305|PubMed:23026136}.		cytoplasm protein quality control by the ubiquitin-proteasome system [GO:0071629]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; regulation of cell population proliferation [GO:0042127]; retrograde transport, endosome to Golgi [GO:0042147]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	epidermal growth factor receptor binding [GO:0005154]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; epidermal growth factor receptor binding [GO:0005154]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; cytoplasm protein quality control by the ubiquitin-proteasome system [GO:0071629]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; regulation of cell population proliferation [GO:0042127]; retrograde transport, endosome to Golgi [GO:0042147]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23026136}. Nucleus {ECO:0000269|PubMed:23026136}.
Q9BV73	reviewed	CP250_HUMAN	Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2)	CEP250 CEP2 CNAP1	Homo sapiens (Human)	2442	FUNCTION: May be involved in ciliogenesis (PubMed:28005958). Probably plays an important role in centrosome cohesion during interphase. Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835}.	MISCELLANEOUS: Antibodies against CEP2 are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins.	centriole-centriole cohesion [GO:0010457]; cilium assembly [GO:0060271]; detection of light stimulus involved in visual perception [GO:0050908]; mitotic cell cycle [GO:0000278]; non-motile cilium assembly [GO:1905515]; positive regulation of protein localization to centrosome [GO:1904781]; protein localization [GO:0008104]; protein localization to centrosome [GO:0071539]; protein localization to organelle [GO:0033365]; regulation of centriole-centriole cohesion [GO:0030997]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; protein-containing complex [GO:0032991]	protein domain specific binding [GO:0019904]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; protein-containing complex [GO:0032991]; protein domain specific binding [GO:0019904]; centriole-centriole cohesion [GO:0010457]; cilium assembly [GO:0060271]; detection of light stimulus involved in visual perception [GO:0050908]; mitotic cell cycle [GO:0000278]; non-motile cilium assembly [GO:1905515]; positive regulation of protein localization to centrosome [GO:1904781]; protein localization [GO:0008104]; protein localization to centrosome [GO:0071539]; protein localization to organelle [GO:0033365]; regulation of centriole-centriole cohesion [GO:0030997]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:9647649}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26337392, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:9647649}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:31974111}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:9647649}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q60952}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q60952}. Note=Component of the core centrosome. In interphase cells, it specifically associates with the proximal ends of both mother and daughter centrioles. Associates with the centrosome in interphase cells. In mitotic cells, it dissociates from the mitotic spindle poles. At the end of cell division, it reaccumulates at centrosomes.
Q9BV79	reviewed	MECR_HUMAN	Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC 1.3.1.104) (2-enoyl thioester reductase) (Nuclear receptor-binding factor 1) (HsNrbf-1) (NRBF-1)	MECR NBRF1 CGI-63	Homo sapiens (Human)	373	FUNCTION: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (PubMed:18479707, PubMed:12654921, PubMed:27817865). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (By similarity). {ECO:0000250|UniProtKB:Q9DCS3, ECO:0000269|PubMed:12654921, ECO:0000269|PubMed:18479707, ECO:0000269|PubMed:27817865}.		fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:12654921}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:25031892}. Nucleus {ECO:0000269|PubMed:25031892}.
Q9BV81	reviewed	EMC6_HUMAN	ER membrane protein complex subunit 6 (Transmembrane protein 93)	EMC6 TMEM93	Homo sapiens (Human)	110	FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305}.		autophagosome assembly [GO:0000045]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; omegasome membrane [GO:1903349]		EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; omegasome membrane [GO:1903349]; autophagosome assembly [GO:0000045]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785, ECO:0000269|PubMed:30415835}; Multi-pass membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}.
Q9BV86	reviewed	NTM1A_HUMAN	N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed]	NTMT1 C9orf32 METTL11A NRMT NRMT1 AD-003	Homo sapiens (Human)	223	FUNCTION: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. {ECO:0000269|PubMed:20481588, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352, ECO:0000269|PubMed:26543159}.		chromosome segregation [GO:0007059]; N-terminal peptidyl-glycine methylation [GO:0018013]; N-terminal peptidyl-proline dimethylation [GO:0018016]; N-terminal peptidyl-serine dimethylation [GO:0035572]; N-terminal peptidyl-serine trimethylation [GO:0035573]; spindle organization [GO:0007051]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone methyltransferase activity [GO:0042054]; N-terminal protein N-methyltransferase activity [GO:0071885]; protein methyltransferase activity [GO:0008276]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone methyltransferase activity [GO:0042054]; N-terminal protein N-methyltransferase activity [GO:0071885]; protein methyltransferase activity [GO:0008276]; chromosome segregation [GO:0007059]; N-terminal peptidyl-glycine methylation [GO:0018013]; N-terminal peptidyl-proline dimethylation [GO:0018016]; N-terminal peptidyl-serine dimethylation [GO:0035572]; N-terminal peptidyl-serine trimethylation [GO:0035573]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352}. Note=Predominantly nuclear (PubMed:24090352).
Q9BV90	reviewed	SNR25_HUMAN	U11/U12 small nuclear ribonucleoprotein 25 kDa protein (U11/U12 snRNP 25 kDa protein) (U11/U12-25K) (Minus-99 protein)	SNRNP25 C16orf33	Homo sapiens (Human)	132			mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type spliceosomal complex [GO:0005689]		cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type spliceosomal complex [GO:0005689]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15146077}.
Q9BV94	reviewed	EDEM2_HUMAN	ER degradation-enhancing alpha-mannosidase-like protein 2	EDEM2 C20orf31 C20orf49 UNQ573/PRO1135	Homo sapiens (Human)	578	FUNCTION: Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity). {ECO:0000250|UniProtKB:Q8BJT9, ECO:0000269|PubMed:15537790, ECO:0000269|PubMed:25092655}.		carbohydrate metabolic process [GO:0005975]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; response to unfolded protein [GO:0006986]; trimming of terminal mannose on B branch [GO:0036509]; ubiquitin-dependent glycoprotein ERAD pathway [GO:0097466]; viral protein processing [GO:0019082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]; carbohydrate metabolic process [GO:0005975]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; response to unfolded protein [GO:0006986]; trimming of terminal mannose on B branch [GO:0036509]; ubiquitin-dependent glycoprotein ERAD pathway [GO:0097466]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15537790}.
Q9BVA0	reviewed	KTNB1_HUMAN	Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin)	KATNB1	Homo sapiens (Human)	655	FUNCTION: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03022, ECO:0000269|PubMed:10751153}.		cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; microtubule depolymerization [GO:0007019]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of apoptotic process [GO:0043065]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of neuron projection development [GO:0010976]; protein targeting [GO:0006605]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; katanin complex [GO:0008352]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle pole [GO:0000922]	ATPase regulator activity [GO:0060590]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; katanin complex [GO:0008352]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle pole [GO:0000922]; ATPase regulator activity [GO:0060590]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]; cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; microtubule depolymerization [GO:0007019]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of apoptotic process [GO:0043065]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of neuron projection development [GO:0010976]; protein targeting [GO:0006605]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26929214, ECO:0000269|PubMed:9658175}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16203747, ECO:0000269|PubMed:9568719}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16203747, ECO:0000269|PubMed:26929214, ECO:0000269|PubMed:9658175}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9568719, ECO:0000269|PubMed:9658175}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26929214}. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles (PubMed:9658175). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214). {ECO:0000269|PubMed:26929214, ECO:0000269|PubMed:9658175}.
Q9BVA1	reviewed	TBB2B_HUMAN	Tubulin beta-2B chain	TUBB2B	Homo sapiens (Human)	445	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:28013290, PubMed:26732629). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}.		cerebral cortex development [GO:0021987]; embryonic brain development [GO:1990403]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; modulation of chemical synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; positive regulation of axon guidance [GO:1902669]	cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; Schaffer collateral - CA1 synapse [GO:0098685]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; Schaffer collateral - CA1 synapse [GO:0098685]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; structural constituent of cytoskeleton [GO:0005200]; cerebral cortex development [GO:0021987]; embryonic brain development [GO:1990403]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; modulation of chemical synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; positive regulation of axon guidance [GO:1902669]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:28013290}.
Q9BVA6	reviewed	FICD_HUMAN	Protein adenylyltransferase FICD (EC 2.7.7.108) (AMPylator FICD) (De-AMPylase FICD) (EC 3.1.4.-) (FIC domain-containing protein) (Huntingtin yeast partner E) (Huntingtin-interacting protein 13) (HIP-13) (Huntingtin-interacting protein E)	FICD HIP13 HYPE UNQ3041/PRO9857	Homo sapiens (Human)	458	FUNCTION: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083). {ECO:0000250|UniProtKB:A0A061I403, ECO:0000269|PubMed:22266942, ECO:0000269|PubMed:25435325, ECO:0000269|PubMed:25601083, ECO:0000305|PubMed:19362538}.		negative regulation of GTPase activity [GO:0034260]; protein adenylylation [GO:0018117]; protein deadenylylation [GO:0044602]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]	endoplasmic reticulum membrane [GO:0005789]	ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; protein adenylylhydrolase activity [GO:0044603]; protein adenylyltransferase activity [GO:0070733]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]	endoplasmic reticulum membrane [GO:0005789]; ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; protein adenylylhydrolase activity [GO:0044603]; protein adenylyltransferase activity [GO:0070733]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; negative regulation of GTPase activity [GO:0034260]; protein adenylylation [GO:0018117]; protein deadenylylation [GO:0044602]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25601083}; Single-pass type II membrane protein {ECO:0000305|PubMed:25601083}.
Q9BVC3	reviewed	DCC1_HUMAN	Sister chromatid cohesion protein DCC1 (Defective in sister chromatid cohesion protein 1 homolog)	DSCC1 DCC1 UNQ9337/PRO34008	Homo sapiens (Human)	393	FUNCTION: Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3. {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:19907496}.		DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; post-translational protein acetylation [GO:0034421]; regulation of DNA replication [GO:0006275]	chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; Ctf18 RFC-like complex [GO:0031390]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]	chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; Ctf18 RFC-like complex [GO:0031390]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; post-translational protein acetylation [GO:0034421]; regulation of DNA replication [GO:0006275]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9BVC4	reviewed	LST8_HUMAN	Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8)	MLST8 GBL LST8	Homo sapiens (Human)	326	FUNCTION: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). mTORC1 is activated in response to growth factors or amino acids (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:24403073). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:24403073). Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity (PubMed:12718876). In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity (PubMed:12718876). mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive (PubMed:15467718). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation (PubMed:15467718). mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:15467718). mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657' (PubMed:15467718). {ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:24403073}.		cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cytoskeleton organization [GO:0007010]; DNA damage response [GO:0006974]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of TOR signaling [GO:0032008]; regulation of actin cytoskeleton organization [GO:0032956]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]	protein serine/threonine kinase activator activity [GO:0043539]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]; protein serine/threonine kinase activator activity [GO:0043539]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cytoskeleton organization [GO:0007010]; DNA damage response [GO:0006974]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of TOR signaling [GO:0032008]; regulation of actin cytoskeleton organization [GO:0032956]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:31601764}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z2K5}. Note=Targeting to lysosomal membrane depends on amino acid availability: mTORC1 is recruited to lysosome membranes via interaction with GTP-bound form of RagA/RRAGA (or RagB/RRAGB) in complex with the GDP-bound form of RagC/RRAGC (or RagD/RRAGD), promoting its mTORC1 recruitment to the lysosomes. {ECO:0000269|PubMed:31601764}.
Q9BVC6	reviewed	TM109_HUMAN	Voltage-gated monoatomic cation channel TMEM109 (Mitsugumin-23) (Mg23) (Transmembrane protein 109)	TMEM109	Homo sapiens (Human)	243	FUNCTION: Functions as a voltage-gated monoatomic cation channel permeable to both potassium and calcium (By similarity). Plays a role in the cellular response to DNA damage (PubMed:23542032). {ECO:0000250|UniProtKB:O77751, ECO:0000269|PubMed:23542032}.		cellular response to gamma radiation [GO:0071480]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of programmed cell death [GO:0043069]; regulation of monoatomic ion transmembrane transport [GO:0034765]	extracellular exosome [GO:0070062]; nuclear outer membrane [GO:0005640]; sarcoplasmic reticulum membrane [GO:0033017]	voltage-gated monoatomic cation channel activity [GO:0022843]	extracellular exosome [GO:0070062]; nuclear outer membrane [GO:0005640]; sarcoplasmic reticulum membrane [GO:0033017]; voltage-gated monoatomic cation channel activity [GO:0022843]; cellular response to gamma radiation [GO:0071480]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of programmed cell death [GO:0043069]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}.
Q9BVG3	reviewed	TRI62_HUMAN	E3 ubiquitin-protein ligase TRIM62 (EC 2.3.2.27) (Tripartite motif-containing protein 62)	TRIM62	Homo sapiens (Human)	475	FUNCTION: E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:26488816). E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (PubMed:23402750). {ECO:0000269|PubMed:23402750, ECO:0000269|PubMed:26488816}.		innate immune response [GO:0045087]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of viral transcription [GO:0032897]; positive regulation of antifungal innate immune response [GO:1905036]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K27-linked ubiquitination [GO:0044314]; protein ubiquitination [GO:0016567]; regulation of viral entry into host cell [GO:0046596]; viral release from host cell [GO:0019076]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of viral transcription [GO:0032897]; positive regulation of antifungal innate immune response [GO:1905036]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K27-linked ubiquitination [GO:0044314]; protein ubiquitination [GO:0016567]; regulation of viral entry into host cell [GO:0046596]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23402750, ECO:0000269|PubMed:26488816}.
Q9BVG8	reviewed	KIFC3_HUMAN	Kinesin-like protein KIFC3	KIFC3	Homo sapiens (Human)	833	FUNCTION: Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. {ECO:0000250, ECO:0000269|PubMed:19041755}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	epithelial cell-cell adhesion [GO:0090136]; Golgi organization [GO:0007030]; microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]; visual perception [GO:0007601]; zonula adherens maintenance [GO:0045218]	centrosome [GO:0005813]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; zonula adherens [GO:0005915]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	centrosome [GO:0005813]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; zonula adherens [GO:0005915]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; epithelial cell-cell adhesion [GO:0090136]; Golgi organization [GO:0007030]; microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]; visual perception [GO:0007601]; zonula adherens maintenance [GO:0045218]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:19041755}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19041755}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells (By similarity). Localizes along zonula adherens only at mature cell-cell contacts. {ECO:0000250}.
Q9BVG9	reviewed	PTSS2_HUMAN	Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II)	PTDSS2 PSS2	Homo sapiens (Human)	487	FUNCTION: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:19014349). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity). {ECO:0000250|UniProtKB:Q9Z1X2, ECO:0000269|PubMed:19014349}.		phosphatidylserine biosynthetic process [GO:0006659]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	CDP-diacylglycerol-serine O-phosphatidyltransferase activity [GO:0003882]; L-serine-phosphatidylethanolamine phosphatidyltransferase activity [GO:0106245]; transferase activity [GO:0016740]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; CDP-diacylglycerol-serine O-phosphatidyltransferase activity [GO:0003882]; L-serine-phosphatidylethanolamine phosphatidyltransferase activity [GO:0106245]; transferase activity [GO:0016740]; phosphatidylserine biosynthetic process [GO:0006659]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z1X2}; Multi-pass membrane protein {ECO:0000255}. Note=Highly enriched in the mitochondria-associated membrane (MAM). {ECO:0000250|UniProtKB:Q9Z1X2}.
Q9BVH7	reviewed	SIA7E_HUMAN	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (EC 2.4.99.-) (GD1 alpha synthase) (GalNAc alpha-2,6-sialyltransferase V) (ST6GalNAc V) (ST6GalNAcV) (Sialyltransferase 7E) (SIAT7-E)	ST6GALNAC5 SIAT7E	Homo sapiens (Human)	336	FUNCTION: Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). {ECO:0000250|UniProtKB:Q9QYJ1, ECO:0000269|PubMed:12668675}.		ganglioside biosynthetic process [GO:0001574]; glycosphingolipid biosynthetic process [GO:0006688]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]	Golgi membrane [GO:0000139]	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; sialyltransferase activity [GO:0008373]	Golgi membrane [GO:0000139]; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; sialyltransferase activity [GO:0008373]; ganglioside biosynthetic process [GO:0001574]; glycosphingolipid biosynthetic process [GO:0006688]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9BVI0	reviewed	PHF20_HUMAN	PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP)	PHF20 C20orf104 GLEA2 HCA58 NZF TZP	Homo sapiens (Human)	1012	FUNCTION: Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}.	MISCELLANEOUS: Antibodies against PHF20 are present in sera from patients with hepatocellular carcinoma, glioblastoma and childhood medulloblastula.	chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20018852}.
Q9BVI4	reviewed	NOC4L_HUMAN	Nucleolar complex protein 4 homolog (NOC4 protein homolog) (NOC4-like protein) (Nucleolar complex-associated protein 4-like protein)	NOC4L	Homo sapiens (Human)	516			rRNA processing [GO:0006364]	Noc4p-Nop14p complex [GO:0030692]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	Noc4p-Nop14p complex [GO:0030692]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:12429849}; Multi-pass membrane protein {ECO:0000269|PubMed:12429849}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Q9BVJ6	reviewed	UT14A_HUMAN	U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16)	UTP14A SDCCAG16	Homo sapiens (Human)	771	FUNCTION: May be required for ribosome biogenesis. {ECO:0000250}.	MISCELLANEOUS: The human genome also contains the UTP14C gene, an autosomal retrotransposed copy of this X-linked gene. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.	rRNA processing [GO:0006364]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Q9BVJ7	reviewed	DUS23_HUMAN	Dual specificity protein phosphatase 23 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z)	DUSP23 LDP3 VHZ	Homo sapiens (Human)	150	FUNCTION: Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). {ECO:0000269|PubMed:15147733, ECO:0000269|PubMed:15201283}.		cilium assembly [GO:0060271]; dephosphorylation [GO:0016311]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cilium assembly [GO:0060271]; dephosphorylation [GO:0016311]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear.
Q9BVK2	reviewed	ALG8_HUMAN	Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8 homolog) (Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase)	ALG8 HUSSY-02	Homo sapiens (Human)	526	FUNCTION: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol before it is transferred to the nascent peptide (By similarity). Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:P40351, ECO:0000250|UniProtKB:Q6P8H8}.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	endoplasmic reticulum membrane [GO:0005789]	alpha-1,3-mannosyltransferase activity [GO:0000033]; dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [GO:0042283]; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity [GO:0004583]	endoplasmic reticulum membrane [GO:0005789]; alpha-1,3-mannosyltransferase activity [GO:0000033]; dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [GO:0042283]; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity [GO:0004583]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9BVK6	reviewed	TMED9_HUMAN	Transmembrane emp24 domain-containing protein 9 (GMP25) (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2) (p25)	TMED9 GP25L2	Homo sapiens (Human)	235	FUNCTION: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:14600267, ECO:0000269|PubMed:16595549, ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:19296914}.		COPI coating of Golgi vesicle [GO:0048205]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of organelle organization [GO:0010638]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; synaptic vesicle [GO:0008021]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133]	syntaxin binding [GO:0019905]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; synaptic vesicle [GO:0008021]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133]; syntaxin binding [GO:0019905]; COPI coating of Golgi vesicle [GO:0048205]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of organelle organization [GO:0010638]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway.
Q9BVK8	reviewed	TM147_HUMAN	BOS complex subunit TMEM147 (Protein NIFIE 14) (Transmembrane protein 147)	TMEM147	Homo sapiens (Human)	224	FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (PubMed:21056967). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (PubMed:21056967). Regulates LBR localization to the nucleus inner membrane (PubMed:32694168). {ECO:0000269|PubMed:21056967, ECO:0000269|PubMed:32694168, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.		multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; protein localization to nuclear inner membrane [GO:0036228]	endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ribosome binding [GO:0043022]	endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ribosome binding [GO:0043022]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; protein localization to nuclear inner membrane [GO:0036228]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20538592, ECO:0000269|PubMed:21056967, ECO:0000269|PubMed:32694168, ECO:0000269|PubMed:36044892, ECO:0000269|PubMed:36261522}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:32694168}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:I6VSD2}; Multi-pass membrane protein {ECO:0000255}.
Q9BVL2	reviewed	NUP58_HUMAN	Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1)	NUP58 KIAA0410 NUPL1	Homo sapiens (Human)	599	FUNCTION: Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {ECO:0000250|UniProtKB:P70581}.	MISCELLANEOUS: In rat, the p62 complex contains two different isoforms of NUP58. Isoform p45 has however not been isolated in human so far.	mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of protein import into nucleus [GO:0042306]	nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]	identical protein binding [GO:0042802]; nuclear localization sequence binding [GO:0008139]; protein-containing complex binding [GO:0044877]; structural constituent of nuclear pore [GO:0017056]	nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; identical protein binding [GO:0042802]; nuclear localization sequence binding [GO:0008139]; protein-containing complex binding [GO:0044877]; structural constituent of nuclear pore [GO:0017056]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of protein import into nucleus [GO:0042306]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P70581}. Nucleus membrane {ECO:0000250|UniProtKB:P70581}; Peripheral membrane protein {ECO:0000250|UniProtKB:P70581}; Cytoplasmic side {ECO:0000250|UniProtKB:P70581}. Nucleus membrane {ECO:0000250|UniProtKB:P70581}; Peripheral membrane protein {ECO:0000250|UniProtKB:P70581}; Nucleoplasmic side {ECO:0000250|UniProtKB:P70581}. Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter. {ECO:0000250|UniProtKB:P70581}.
Q9BVL4	reviewed	SELO_HUMAN	Protein adenylyltransferase SelO, mitochondrial (EC 2.7.7.-) (EC 2.7.7.108) (Selenoprotein O) (SelO)	SELENOO SELO	Homo sapiens (Human)	669	FUNCTION: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation) (PubMed:30270044). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein (PubMed:24751718). {ECO:0000269|PubMed:24751718, ECO:0000269|PubMed:30270044}.		protein adenylylation [GO:0018117]	chromosome [GO:0005694]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein adenylyltransferase activity [GO:0070733]	chromosome [GO:0005694]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein adenylyltransferase activity [GO:0070733]; protein adenylylation [GO:0018117]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:24751718}.
Q9BVM4	reviewed	GGACT_HUMAN	Gamma-glutamylaminecyclotransferase (GGACT) (EC 4.3.2.8) (AIG2-like domain-containing protein 1) (Gamma-glutamylamine cyclotransferase)	GGACT A2LD1	Homo sapiens (Human)	153	FUNCTION: Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine. {ECO:0000269|PubMed:20110353}.		cellular modified amino acid catabolic process [GO:0042219]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	gamma-glutamylaminecyclotransferase activity [GO:0061929]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; gamma-glutamylaminecyclotransferase activity [GO:0061929]; cellular modified amino acid catabolic process [GO:0042219]	
Q9BVN2	reviewed	RUSC1_HUMAN	AP-4 complex accessory subunit RUSC1 (New molecule containing SH3 at the carboxy-terminus) (Nesca) (RUN and SH3 domain-containing protein 1)	RUSC1 NESCA	Homo sapiens (Human)	902	FUNCTION: Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network (PubMed:30262884). Signaling adapter which plays a role in neuronal differentiation (PubMed:15024033). Involved in regulation of NGF-dependent neurite outgrowth (PubMed:15024033). May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (By similarity). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK (PubMed:15024033). Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway (PubMed:19365808). {ECO:0000250|UniProtKB:Q8BG26, ECO:0000269|PubMed:15024033, ECO:0000269|PubMed:19365808, ECO:0000269|PubMed:30262884}.		protein polyubiquitination [GO:0000209]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	actin binding [GO:0003779]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; actin binding [GO:0003779]; protein polyubiquitination [GO:0000209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15024033}. Nucleus {ECO:0000269|PubMed:15024033}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8BG26}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q8BG26}. Early endosome {ECO:0000250|UniProtKB:Q8BG26}. Postsynaptic density {ECO:0000250|UniProtKB:Q8BG26}. Golgi apparatus {ECO:0000250|UniProtKB:Q8BG26}. Note=Translocated to the nuclear envelope upon stimulation with NGF (PubMed:15024033). Associated with membranes and microtubules (By similarity). {ECO:0000250|UniProtKB:Q8BG26, ECO:0000269|PubMed:15024033}.
Q9BVP2	reviewed	GNL3_HUMAN	Guanine nucleotide-binding protein-like 3 (E2-induced gene 3 protein) (Novel nucleolar protein 47) (NNP47) (Nucleolar GTP-binding protein 3) (Nucleostemin)	GNL3 E2IG3 NS	Homo sapiens (Human)	549	FUNCTION: May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12464630, ECO:0000269|PubMed:16012751}.		positive regulation of miRNA transcription [GO:1902895]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of telomere maintenance [GO:0032206]; regulation of cell population proliferation [GO:0042127]; stem cell division [GO:0017145]; stem cell population maintenance [GO:0019827]	chromosome [GO:0005694]; extracellular space [GO:0005615]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GTP binding [GO:0005525]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]	chromosome [GO:0005694]; extracellular space [GO:0005615]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleus [GO:0005634]; GTP binding [GO:0005525]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of telomere maintenance [GO:0032206]; regulation of cell population proliferation [GO:0042127]; stem cell division [GO:0017145]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q811S9}. Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:12464630}. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250|UniProtKB:Q811S9}.
Q9BVQ7	reviewed	AFG2B_HUMAN	ATPase family gene 2 protein homolog B (EC 3.6.4.10) (AFG2 AAA ATPase homolog B) (Ribosome biogenesis protein SPATA5L1) (Spermatogenesis-associated protein 5-like protein 1)	AFG2B SPATA5L1	Homo sapiens (Human)	753	FUNCTION: ATP-dependent chaperone, which plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). Acts together with AFG2A, AIRIM and CINP (PubMed:35354024). {ECO:0000269|PubMed:35354024}.		ribosomal large subunit biogenesis [GO:0042273]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle [GO:0005819]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle [GO:0005819]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275]; ribosomal large subunit biogenesis [GO:0042273]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Nucleus {ECO:0000250|UniProtKB:D4A2B7}.
Q9BVS4	reviewed	RIOK2_HUMAN	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2)	RIOK2 RIO2	Homo sapiens (Human)	552	FUNCTION: Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}.		cell cycle [GO:0007049]; maturation of SSU-rRNA [GO:0030490]; positive regulation of ribosomal small subunit export from nucleus [GO:2000208]; positive regulation of rRNA processing [GO:2000234]; protein autophosphorylation [GO:0046777]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ribosomal small subunit biogenesis [GO:0042274]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell cycle [GO:0007049]; maturation of SSU-rRNA [GO:0030490]; positive regulation of ribosomal small subunit export from nucleus [GO:2000208]; positive regulation of rRNA processing [GO:2000234]; protein autophosphorylation [GO:0046777]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402}. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. {ECO:0000269|PubMed:19564402}.
Q9BVS5	reviewed	TR61B_HUMAN	tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-)	TRMT61B	Homo sapiens (Human)	477	FUNCTION: Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537). {ECO:0000269|PubMed:23097428, ECO:0000269|PubMed:27631568, ECO:0000269|PubMed:29107537}.		mitochondrial tRNA methylation [GO:0070901]; mRNA methylation [GO:0080009]; protein homooligomerization [GO:0051260]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; tRNA (m1A) methyltransferase complex [GO:0031515]	mRNA (adenine-N1-)-methyltransferase activity [GO:0061953]; rRNA (adenine) methyltransferase activity [GO:0016433]; tRNA (adenine-N1-)-methyltransferase activity [GO:0016429]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; tRNA (m1A) methyltransferase complex [GO:0031515]; mRNA (adenine-N1-)-methyltransferase activity [GO:0061953]; rRNA (adenine) methyltransferase activity [GO:0016433]; tRNA (adenine-N1-)-methyltransferase activity [GO:0016429]; mitochondrial tRNA methylation [GO:0070901]; mRNA methylation [GO:0080009]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:23097428, ECO:0000269|PubMed:27184847}.
Q9BVT8	reviewed	TMUB1_HUMAN	Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS]	TMUB1 C7orf21 DULP HOPS SB144 UNQ763/PRO1555	Homo sapiens (Human)	246	FUNCTION: Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as negative regulator of hepatocyte growth during regeneration (By similarity). {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3, ECO:0000269|PubMed:21343306}.; FUNCTION: [iHOPS]: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity). {ECO:0000250|UniProtKB:Q9JMG3}.		ubiquitin-dependent ERAD pathway [GO:0030433]	microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]		microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9JMG3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JMG3}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9JMG3}. Recycling endosome {ECO:0000250|UniProtKB:Q53AQ4}. Cytoplasm {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3}.; SUBCELLULAR LOCATION: [iHOPS]: Cytoplasm {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}. Note=iHOPS is proposed to be the shuttling form across different cellular compartments. XPO1-dependent exported from the nucleus in dividing cells. Predominantly nuclear during growth arrest. {ECO:0000250|UniProtKB:Q9JMG3}.
Q9BVV2	reviewed	FND11_HUMAN	Fibronectin type III domain-containing protein 11	FNDC11 C20orf195	Homo sapiens (Human)	318							
Q9BVV6	reviewed	TALD3_HUMAN	Protein TALPID3	KIAA0586 TALPID3	Homo sapiens (Human)	1533	FUNCTION: Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). {ECO:0000250|UniProtKB:E9PV87, ECO:0000250|UniProtKB:Q1G7G9, ECO:0000269|PubMed:24421332}.		cilium assembly [GO:0060271]; regulation of establishment of protein localization [GO:0070201]; smoothened signaling pathway [GO:0007224]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917]; cilium assembly [GO:0060271]; regulation of establishment of protein localization [GO:0070201]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19144723}. Photoreceptor inner segment {ECO:0000269|PubMed:26386247}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:26386247}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:26386247}. Note=Forms a ring-like structure at the extreme distal end of both mother and daughter centrioles (PubMed:24421332). In photoreceptor cells localized to the joint between the inner and outer segments, specifically localized at the mother centriole (basal body) and the adjacent centriole as well as between the two centrioles but not in the connecting cilium (PubMed:26386247). {ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:26386247}.
Q9BVV7	reviewed	TIM21_HUMAN	Mitochondrial import inner membrane translocase subunit Tim21 (TIM21-like protein, mitochondrial)	TIMM21 C18orf55 TIM21 HSPC154	Homo sapiens (Human)	248	FUNCTION: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. {ECO:0000269|PubMed:23260140}.		intracellular protein transport [GO:0006886]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex I assembly [GO:0032981]; protein import into mitochondrial matrix [GO:0030150]	mitochondrial inner membrane [GO:0005743]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]		mitochondrial inner membrane [GO:0005743]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; intracellular protein transport [GO:0006886]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex I assembly [GO:0032981]; protein import into mitochondrial matrix [GO:0030150]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9BVW5	reviewed	TIPIN_HUMAN	TIMELESS-interacting protein	TIPIN	Homo sapiens (Human)	301	FUNCTION: Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:23359676, PubMed:35585232, PubMed:17102137). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:23359676, PubMed:35585232, PubMed:17102137, PubMed:17116885, PubMed:17296725). {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:35585232}.		cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; DNA replication checkpoint signaling [GO:0000076]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of cell population proliferation [GO:0008284]; regulation of nuclear cell cycle DNA replication [GO:0033262]; replication fork arrest [GO:0043111]; replication fork processing [GO:0031297]; response to UV [GO:0009411]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork protection complex [GO:0031298]	DNA binding [GO:0003677]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork protection complex [GO:0031298]; DNA binding [GO:0003677]; cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; DNA replication checkpoint signaling [GO:0000076]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of cell population proliferation [GO:0008284]; regulation of nuclear cell cycle DNA replication [GO:0033262]; replication fork arrest [GO:0043111]; replication fork processing [GO:0031297]; response to UV [GO:0009411]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17141802}. Nucleus {ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17141802}.
Q9BVX2	reviewed	T106C_HUMAN	Transmembrane protein 106C (Endoplasmic reticulum membrane protein overexpressed in cancer)	TMEM106C EMOC	Homo sapiens (Human)	250				endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|Ref.1}; Multi-pass membrane protein {ECO:0000269|Ref.1}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Q9BW04	reviewed	SARG_HUMAN	Specifically androgen-regulated gene protein	SARG C1orf116	Homo sapiens (Human)	601	FUNCTION: Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15525603}.
Q9BW11	reviewed	MAD3_HUMAN	Max dimerization protein 3 (Max dimerizer 3) (Class C basic helix-loop-helix protein 13) (bHLHc13) (Max-associated protein 3) (Max-interacting transcriptional repressor MAD3) (Myx)	MXD3 BHLHC13 MAD3	Homo sapiens (Human)	206	FUNCTION: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q9BW19	reviewed	KIFC1_HUMAN	Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET)	KIFC1 HSET KNSL2	Homo sapiens (Human)	673	FUNCTION: Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). {ECO:0000250|UniProtKB:Q9QWT9, ECO:0000269|PubMed:15843429}.	MISCELLANEOUS: HeLa cells lacking KIFC1 show multipolar mitotic spindles and a defect in chromosome congression and chromosome alignment during mitosis.	cell division [GO:0051301]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]	early endosome [GO:0005769]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	early endosome [GO:0005769]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; cell division [GO:0051301]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9QWT9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9QWT9}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9QWT9}. Early endosome {ECO:0000250|UniProtKB:Q9QWT9}. Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis. {ECO:0000250|UniProtKB:Q9QWT9}.
Q9BW27	reviewed	NUP85_HUMAN	Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (FROUNT) (Nucleoporin Nup75) (Nucleoporin Nup85) (Pericentrin-1)	NUP85 NUP75 PCNT1	Homo sapiens (Human)	656	FUNCTION: Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872). As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus (PubMed:12718872). The Nup107-160 complex seems to be required for spindle assembly during mitosis (PubMed:16807356). NUP85 is required for membrane clustering of CCL2-activated CCR2 (PubMed:15995708). Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade (PubMed:15995708). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12718872, ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:16807356, ECO:0000269|PubMed:30179222}.		lamellipodium assembly [GO:0030032]; macrophage chemotaxis [GO:0048246]; mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nucleocytoplasmic transport [GO:0006913]; positive regulation of DNA-templated transcription [GO:0045893]; protein import into nucleus [GO:0006606]	cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; spindle [GO:0005819]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; structural constituent of nuclear pore [GO:0017056]; lamellipodium assembly [GO:0030032]; macrophage chemotaxis [GO:0048246]; mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nucleocytoplasmic transport [GO:0006913]; positive regulation of DNA-templated transcription [GO:0045893]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:12196509, ECO:0000269|PubMed:12718872}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12718872, ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:16807356}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16807356}. Cytoplasm {ECO:0000269|PubMed:15995708}. Nucleus membrane {ECO:0000269|PubMed:12196509}. Note=During mitosis, localizes to the kinetochores and spindle poles (PubMed:12718872, PubMed:16807356). Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells (PubMed:15995708). {ECO:0000269|PubMed:12718872, ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:16807356}.
Q9BW60	reviewed	ELOV1_HUMAN	Elongation of very long chain fatty acids protein 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Very long chain 3-ketoacyl-CoA synthase 1) (Very long chain 3-oxoacyl-CoA synthase 1)	ELOVL1 SSC1 CGI-88	Homo sapiens (Human)	279	FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905). Indirectly inhibits RPE65 via production of VLCFAs. {ECO:0000255|HAMAP-Rule:MF_03201, ECO:0000269|PubMed:20166112, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:29496980, ECO:0000269|PubMed:30487246}.		alpha-linolenic acid metabolic process [GO:0036109]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; linoleic acid metabolic process [GO:0043651]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	fatty acid elongase activity [GO:0009922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; fatty acid elongase activity [GO:0009922]; alpha-linolenic acid metabolic process [GO:0036109]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; linoleic acid metabolic process [GO:0043651]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03201, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:30487246}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03201}.
Q9BW61	reviewed	DDA1_HUMAN	DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1)	DDA1 C19orf58 PCIA1	Homo sapiens (Human)	102	FUNCTION: Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17452440, PubMed:28437394, PubMed:28302793, PubMed:31686031, PubMed:31819272). In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex (PubMed:31686031, PubMed:31819272). {ECO:0000269|PubMed:17452440, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31819272}.		positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]	
Q9BW62	reviewed	KATL1_HUMAN	Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit A-like 1) (EC 5.6.1.1) (p60 katanin-like 1)	KATNAL1	Homo sapiens (Human)	490	FUNCTION: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (PubMed:26929214). {ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214}.		cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013]; spermatogenesis [GO:0007283]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; katanin complex [GO:0008352]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; katanin complex [GO:0008352]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568]; cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03024, ECO:0000269|PubMed:22654668}. Cytoplasm {ECO:0000269|PubMed:26929214}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:26929214}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26929214}. Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214). {ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214}.
Q9BW66	reviewed	CINP_HUMAN	Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein)	CINP	Homo sapiens (Human)	212	FUNCTION: Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication (PubMed:16082200, PubMed:19889979). Regulates ATR-mediated checkpoint signaling in response to DNA damage (PubMed:19889979). Also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). Promotes maturation of pre-60S ribosome together with AFG2A, AFG2B and AIRIM (PubMed:35354024). {ECO:0000269|PubMed:16082200, ECO:0000269|PubMed:19889979, ECO:0000269|PubMed:35354024}.		cell cycle [GO:0007049]; cell division [GO:0051301]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; ribosomal large subunit biogenesis [GO:0042273]	nucleus [GO:0005634]	preribosome binding [GO:1990275]	nucleus [GO:0005634]; preribosome binding [GO:1990275]; cell cycle [GO:0007049]; cell division [GO:0051301]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; ribosomal large subunit biogenesis [GO:0042273]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19889979}. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication. {ECO:0000269|PubMed:19889979}.
Q9BW71	reviewed	HIRP3_HUMAN	HIRA-interacting protein 3	HIRIP3	Homo sapiens (Human)	556	FUNCTION: May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. {ECO:0000269|PubMed:9710638}.		chromatin organization [GO:0006325]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin organization [GO:0006325]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17391060}. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis.
Q9BW83	reviewed	IFT27_HUMAN	Intraflagellar transport protein 27 homolog (Putative GTP-binding protein RAY-like) (Rab-like protein 4)	IFT27 RABL4 RAYL	Homo sapiens (Human)	186	FUNCTION: Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity). {ECO:0000250|UniProtKB:A8HN58, ECO:0000269|PubMed:25443296}.		cilium assembly [GO:0060271]; cochlea development [GO:0090102]; inner ear receptor cell stereocilium organization [GO:0060122]; intracellular protein transport [GO:0006886]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]; vesicle-mediated transport [GO:0016192]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cilium assembly [GO:0060271]; cochlea development [GO:0090102]; inner ear receptor cell stereocilium organization [GO:0060122]; intracellular protein transport [GO:0006886]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:25443296}. Cytoplasm {ECO:0000250|UniProtKB:Q9D0P8}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D0P8}. Note=Localizes to the sperm flagellum. {ECO:0000250|UniProtKB:Q9D0P8}.
Q9BW85	reviewed	YJU2_HUMAN	Splicing factor YJU2 (Coiled-coil domain-containing protein 94)	YJU2 CCDC94	Homo sapiens (Human)	323	FUNCTION: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:29301961). Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453). {ECO:0000255|HAMAP-Rule:MF_03226, ECO:0000269|PubMed:22952453, ECO:0000269|PubMed:29301961}.		generation of catalytic spliceosome for first transesterification step [GO:0000349]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; RNA splicing [GO:0008380]	nucleoplasm [GO:0005654]; U2-type catalytic step 1 spliceosome [GO:0071006]	metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; U2-type catalytic step 1 spliceosome [GO:0071006]; metal ion binding [GO:0046872]; generation of catalytic spliceosome for first transesterification step [GO:0000349]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03226, ECO:0000269|PubMed:29301961}.
Q9BW91	reviewed	NUDT9_HUMAN	ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9)	NUDT9 NUDT10 PSEC0099 UNQ3012/PRO9771	Homo sapiens (Human)	350	FUNCTION: Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}.		ADP catabolic process [GO:0046032]; IDP catabolic process [GO:0046709]; nucleobase-containing small molecule metabolic process [GO:0055086]	cell junction [GO:0030054]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]	ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]	cell junction [GO:0030054]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]; ADP catabolic process [GO:0046032]; IDP catabolic process [GO:0046709]; nucleobase-containing small molecule metabolic process [GO:0055086]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion.
Q9BW92	reviewed	SYTM_HUMAN	Threonine--tRNA ligase, mitochondrial (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase-like 1)	TARS2 TARSL1	Homo sapiens (Human)	718	FUNCTION: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain. {ECO:0000269|PubMed:26811336}.		mitochondrial threonyl-tRNA aminoacylation [GO:0070159]; threonyl-tRNA aminoacylation [GO:0006435]	mitochondrial matrix [GO:0005759]	aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; threonine-tRNA ligase activity [GO:0004829]	mitochondrial matrix [GO:0005759]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; threonine-tRNA ligase activity [GO:0004829]; mitochondrial threonyl-tRNA aminoacylation [GO:0070159]; threonyl-tRNA aminoacylation [GO:0006435]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
Q9BWC9	reviewed	CC106_HUMAN	Coiled-coil domain-containing protein 106	CCDC106	Homo sapiens (Human)	280	FUNCTION: Promotes the degradation of p53/TP53 protein and inhibits its transactivity. {ECO:0000269|PubMed:20159018}.			cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20159018}. Note=Colocalizes with p53/TP53.
Q9BWD1	reviewed	THIC_HUMAN	Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase)	ACAT2 ACTL	Homo sapiens (Human)	397	FUNCTION: Involved in the biosynthetic pathway of cholesterol. {ECO:0000303|PubMed:15733928}.		fatty acid beta-oxidation [GO:0006635]; lipid metabolic process [GO:0006629]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	acetyl-CoA C-acetyltransferase activity [GO:0003985]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; fatty acid beta-oxidation [GO:0006635]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:7911016}.
Q9BWE0	reviewed	REPI1_HUMAN	Replication initiator 1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464)	REPIN1 RIP60 ZNF464	Homo sapiens (Human)	567	FUNCTION: Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending.		DNA replication [GO:0006260]; regulation of transcription by RNA polymerase II [GO:0006357]	chromosome [GO:0005694]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]	chromatin insulator sequence binding [GO:0043035]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	chromosome [GO:0005694]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; chromatin insulator sequence binding [GO:0043035]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; DNA replication [GO:0006260]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10606657}.
Q9BWF2	reviewed	TRAIP_HUMAN	E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein)	TRAIP RNF206 TRIP	Homo sapiens (Human)	469	FUNCTION: E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:25335891, PubMed:26781088, PubMed:27462463, PubMed:26711499, PubMed:26595769, PubMed:31545170). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is however controversial (PubMed:26595769). Acts as a regulator of the spindle assembly checkpoint (PubMed:25335891). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920). {ECO:0000250|UniProtKB:Q6NRV0, ECO:0000269|PubMed:22945920, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:25335891, ECO:0000269|PubMed:26595769, ECO:0000269|PubMed:26711499, ECO:0000269|PubMed:26781088, ECO:0000269|PubMed:27462463, ECO:0000269|PubMed:31545170}.		apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; replication fork processing [GO:0031297]; signal transduction [GO:0007165]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; site of DNA damage [GO:0090734]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; site of DNA damage [GO:0090734]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; replication fork processing [GO:0031297]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:26595769, ECO:0000269|PubMed:26820530, ECO:0000269|PubMed:30165463}. Nucleus, nucleolus {ECO:0000269|PubMed:14676304, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:25335891, ECO:0000269|PubMed:27462463, ECO:0000269|PubMed:30165463}. Chromosome {ECO:0000269|PubMed:25335891, ECO:0000269|PubMed:26595769, ECO:0000269|PubMed:26711499, ECO:0000269|PubMed:26781088, ECO:0000269|PubMed:30165463}. Cytoplasm. Cytoplasm, perinuclear region {ECO:0000269|PubMed:14676304}. Note=In the nucleus, found in close proximity to PCNA, suggesting localization at replication foci (PubMed:26595769). Localizes to DNA damage sites in response to replication stress (PubMed:26781088, PubMed:26595769, PubMed:26711499). {ECO:0000269|PubMed:26595769, ECO:0000269|PubMed:26711499, ECO:0000269|PubMed:26781088}.
Q9BWF3	reviewed	RBM4_HUMAN	RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a)	RBM4 RBM4A	Homo sapiens (Human)	364	FUNCTION: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to exon skipping. {ECO:0000305}.	cap-independent translational initiation [GO:0002190]; circadian regulation of gene expression [GO:0032922]; circadian regulation of translation [GO:0097167]; enteroendocrine cell differentiation [GO:0035883]; entrainment of circadian clock by photoperiod [GO:0043153]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; IRES-dependent translational initiation of linear mRNA [GO:0002192]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of translation [GO:0017148]; negative regulation of translation in response to stress [GO:0032055]; negative regulation of translational initiation [GO:0045947]; pancreas development [GO:0031016]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of nucleocytoplasmic transport [GO:0046822]; response to arsenic-containing substance [GO:0046685]; RNA processing [GO:0006396]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	cyclin binding [GO:0030332]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; pre-mRNA intronic pyrimidine-rich binding [GO:0097158]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; cyclin binding [GO:0030332]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; pre-mRNA intronic pyrimidine-rich binding [GO:0097158]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; cap-independent translational initiation [GO:0002190]; circadian regulation of gene expression [GO:0032922]; circadian regulation of translation [GO:0097167]; enteroendocrine cell differentiation [GO:0035883]; entrainment of circadian clock by photoperiod [GO:0043153]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; IRES-dependent translational initiation of linear mRNA [GO:0002192]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of translation [GO:0017148]; negative regulation of translation in response to stress [GO:0032055]; negative regulation of translational initiation [GO:0045947]; pancreas development [GO:0031016]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of nucleocytoplasmic transport [GO:0046822]; response to arsenic-containing substance [GO:0046685]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Nucleus speckle. Cytoplasm. Cytoplasmic granule. Note=Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation.
Q9BWG6	reviewed	SCNM1_HUMAN	Sodium channel modifier 1	SCNM1	Homo sapiens (Human)	230	FUNCTION: As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:36084634). Plays a role in the regulation of primary cilia length and Hedgehog signaling (PubMed:36084634). {ECO:0000269|PubMed:36084634}.		alternative mRNA splicing, via spliceosome [GO:0000380]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	enzyme binding [GO:0019899]; metal ion binding [GO:0046872]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; alternative mRNA splicing, via spliceosome [GO:0000380]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17656373}. Nucleus speckle {ECO:0000269|PubMed:17656373}. Note=Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles. {ECO:0000250|UniProtKB:Q8K136}.
Q9BWH2	reviewed	FUND2_HUMAN	FUN14 domain-containing protein 2 (Cervical cancer proto-oncogene 3 protein) (HCC-3) (Hepatitis C virus core-binding protein 6)	FUNDC2 HCBP6 DC44 HCC3 PD03104	Homo sapiens (Human)	189	FUNCTION: Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (PubMed:29187281, PubMed:25855506). {ECO:0000269|PubMed:25855506, ECO:0000269|PubMed:29187281, ECO:0000269|PubMed:29786068}.		autophagy of mitochondrion [GO:0000422]; intracellular triglyceride homeostasis [GO:0035356]; regulation of platelet activation [GO:0010543]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; autophagy of mitochondrion [GO:0000422]; intracellular triglyceride homeostasis [GO:0035356]; regulation of platelet activation [GO:0010543]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:29786068}; Multi-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000305|PubMed:29187281}.
Q9BWH6	reviewed	RPAP1_HUMAN	RNA polymerase II-associated protein 1	RPAP1 KIAA1403	Homo sapiens (Human)	1393	FUNCTION: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	transcription by RNA polymerase II [GO:0006366]	DNA-directed RNA polymerase complex [GO:0000428]; nucleus [GO:0005634]	DNA binding [GO:0003677]; nucleotidyltransferase activity [GO:0016779]	DNA-directed RNA polymerase complex [GO:0000428]; nucleus [GO:0005634]; DNA binding [GO:0003677]; nucleotidyltransferase activity [GO:0016779]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9BWJ5	reviewed	SF3B5_HUMAN	Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit)	SF3B5 SF3B10	Homo sapiens (Human)	86	FUNCTION: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28781166, ECO:0000305|PubMed:33509932}.		mRNA splicing, via spliceosome [GO:0000398]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; U2-type prespliceosome assembly [GO:1903241]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; SAGA complex [GO:0000124]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	RNA binding [GO:0003723]; splicing factor binding [GO:1990935]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; SAGA complex [GO:0000124]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300, ECO:0000269|PubMed:28781166}.
Q9BWK5	reviewed	CYREN_HUMAN	Cell cycle regulator of non-homologous end joining (Cell cycle regulator of NHEJ) (Modulator of retrovirus infection homolog)	CYREN C7orf49 MRI	Homo sapiens (Human)	157	FUNCTION: Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (PubMed:24610814, PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 (PubMed:28959974). In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin. Also involved in immunoglobulin V(D)J recombination (By similarity). May also act as an indirect regulator of proteasome (By similarity). {ECO:0000250|UniProtKB:Q09HN1, ECO:0000250|UniProtKB:Q8BHZ5, ECO:0000269|PubMed:24610814, ECO:0000269|PubMed:28959974}.		double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:24610814}. Nucleus {ECO:0000269|PubMed:24610814}. Chromosome {ECO:0000269|PubMed:27063109}. Note=Nuclear localization may depend upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (PubMed:24610814). Localizes to DNA damage sites (PubMed:27063109). {ECO:0000269|PubMed:24610814, ECO:0000269|PubMed:27063109}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:24610814}. Note=Some nuclear localization may be due to passive diffusion. {ECO:0000269|PubMed:24610814}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:24610814}. Nucleus {ECO:0000269|PubMed:24610814}. Note=Nuclear localization may depend upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer and increases upon etoposide treatment. {ECO:0000269|PubMed:24610814}.
Q9BWL3	reviewed	CA043_HUMAN	Protein C1orf43 (Hepatitis C virus NS5A-transactivated protein 4) (HCV NS5A-transactivated protein 4) (Protein NICE-3) (S863-3)	C1orf43 NICE3 NS5ATP4 HSPC012	Homo sapiens (Human)	253	FUNCTION: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages. {ECO:0000269|PubMed:31540829}.		in utero embryonic development [GO:0001701]; phagocytosis [GO:0006909]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; in utero embryonic development [GO:0001701]; phagocytosis [GO:0006909]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:31540829}. Mitochondrion {ECO:0000269|PubMed:31540829}.
Q9BWM7	reviewed	SFXN3_HUMAN	Sideroflexin-3	SFXN3	Homo sapiens (Human)	321	FUNCTION: Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). {ECO:0000269|PubMed:30442778}.		mitochondrial transmembrane transport [GO:1990542]; one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300]	mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	monoatomic ion transmembrane transporter activity [GO:0015075]; serine transmembrane transporter activity [GO:0022889]	mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; monoatomic ion transmembrane transporter activity [GO:0015075]; serine transmembrane transporter activity [GO:0022889]; mitochondrial transmembrane transport [GO:1990542]; one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:30442778, ECO:0000269|Ref.4}; Multi-pass membrane protein {ECO:0000255}.
Q9BWN1	reviewed	PRR14_HUMAN	Proline-rich protein 14	PRR14	Homo sapiens (Human)	585	FUNCTION: Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157, ECO:0000269|PubMed:27041574}.		muscle organ development [GO:0007517]	chromosome [GO:0005694]; nuclear lamina [GO:0005652]; nucleoplasm [GO:0005654]		chromosome [GO:0005694]; nuclear lamina [GO:0005652]; nucleoplasm [GO:0005654]; muscle organ development [GO:0007517]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:24209742}. Nucleus {ECO:0000269|PubMed:25906157}. Nucleus lamina {ECO:0000269|PubMed:24209742}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24209742}. Note=During interphase, associated with peripheral heterochromatin at the nuclear lamina. Released from the nuclear lamina in mitotic prophase and remains highly dispersed in metaphase. Associates with chromatin at the onset of anaphase and relocalizes to the nuclear lamina in telophase. {ECO:0000269|PubMed:24209742}.
Q9BWP8	reviewed	COL11_HUMAN	Collectin-11 (Collectin kidney protein 1) (CL-K1)	COLEC11 UNQ596/PRO1182	Homo sapiens (Human)	271	FUNCTION: Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:23954398, PubMed:25912189, PubMed:21258343). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343, PubMed:28301481). {ECO:0000269|PubMed:17179669, ECO:0000269|PubMed:20956340, ECO:0000269|PubMed:21258343, ECO:0000269|PubMed:23954398, ECO:0000269|PubMed:25912189, ECO:0000269|PubMed:28301481, ECO:0000305|PubMed:20956340, ECO:0000305|PubMed:23954398}.		antimicrobial humoral response [GO:0019730]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation [GO:0006956]; complement activation, lectin pathway [GO:0001867]; developmental process [GO:0032502]; execution phase of apoptosis [GO:0097194]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]	collagen trimer [GO:0005581]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370]	calcium ion binding [GO:0005509]; calcium-dependent carbohydrate binding [GO:0120153]; DNA binding [GO:0003677]; fucose binding [GO:0042806]; identical protein binding [GO:0042802]; mannose binding [GO:0005537]; oligosaccharide binding [GO:0070492]	collagen trimer [GO:0005581]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370]; calcium ion binding [GO:0005509]; calcium-dependent carbohydrate binding [GO:0120153]; DNA binding [GO:0003677]; fucose binding [GO:0042806]; identical protein binding [GO:0042802]; mannose binding [GO:0005537]; oligosaccharide binding [GO:0070492]; antimicrobial humoral response [GO:0019730]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation [GO:0006956]; complement activation, lectin pathway [GO:0001867]; developmental process [GO:0032502]; execution phase of apoptosis [GO:0097194]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25912189}.
Q9BWQ6	reviewed	YIPF2_HUMAN	Protein YIPF2 (YIP1 family member 2)	YIPF2	Homo sapiens (Human)	316			vesicle-mediated transport [GO:0016192]	Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; late endosome membrane [GO:0031902]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]	small GTPase binding [GO:0031267]	Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; late endosome membrane [GO:0031902]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]; small GTPase binding [GO:0031267]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27999994}. Late endosome membrane {ECO:0000269|PubMed:27999994}. Note=Mainly localizes within medial-/trans-Golgi and trans-Golgi network (TGN), while less so within cis-Golgi. {ECO:0000269|PubMed:27999994, ECO:0000269|PubMed:28286305}.
Q9BWQ8	reviewed	LFG2_HUMAN	Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) (Neural membrane protein 35) (Transmembrane BAX inhibitor motif-containing protein 2)	FAIM2 KIAA0950 LFG LFG2 NMP35 TMBIM2	Homo sapiens (Human)	316	FUNCTION: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. {ECO:0000269|PubMed:10535980, ECO:0000269|PubMed:17635665}.		apoptotic signaling pathway [GO:0097190]; cerebellar granular layer development [GO:0021681]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum development [GO:0021549]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; regulation of neuron apoptotic process [GO:0043523]; response to ischemia [GO:0002931]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; postsynaptic membrane [GO:0045211]		endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; postsynaptic membrane [GO:0045211]; apoptotic signaling pathway [GO:0097190]; cerebellar granular layer development [GO:0021681]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum development [GO:0021549]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; regulation of neuron apoptotic process [GO:0043523]; response to ischemia [GO:0002931]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane raft {ECO:0000269|PubMed:17635665}. Postsynaptic cell membrane {ECO:0000250}.
Q9BWS9	reviewed	CHID1_HUMAN	Chitinase domain-containing protein 1 (Stabilin-1-interacting chitinase-like protein) (SI-CLP)	CHID1 GL008 PSEC0104 SB139	Homo sapiens (Human)	393	FUNCTION: Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro). {ECO:0000269|PubMed:20724479}.		carbohydrate metabolic process [GO:0005975]; innate immune response [GO:0045087]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]	endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]	chitin binding [GO:0008061]; oligosaccharide binding [GO:0070492]	endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]; chitin binding [GO:0008061]; oligosaccharide binding [GO:0070492]; carbohydrate metabolic process [GO:0005975]; innate immune response [GO:0045087]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16357325}. Lysosome {ECO:0000269|PubMed:16357325}.
Q9BWT1	reviewed	CDCA7_HUMAN	Cell division cycle-associated protein 7 (Protein JPO1)	CDCA7 JPO1	Homo sapiens (Human)	371	FUNCTION: Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator. {ECO:0000269|PubMed:11598121, ECO:0000269|PubMed:15994934, ECO:0000269|PubMed:16580749, ECO:0000269|PubMed:23166294}.	MISCELLANEOUS: CDCA7 expression is correlated with MYC expression in lymphoblastoid, lymphoma and breast cancer cell lines.	apoptotic process [GO:0006915]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163.
Q9BWT3	reviewed	PAPOG_HUMAN	Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme)	PAPOLG PAP2 PAPG	Homo sapiens (Human)	736	FUNCTION: Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}.		mRNA polyadenylation [GO:0006378]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; mRNA polyadenylation [GO:0006378]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11431479, ECO:0000269|PubMed:11463842}.
Q9BWT7	reviewed	CAR10_HUMAN	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3)	CARD10 CARMA3	Homo sapiens (Human)	1032	FUNCTION: Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. {ECO:0000269|PubMed:27991920}.		activation of NF-kappaB-inducing kinase activity [GO:0007250]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of protein localization to nucleus [GO:1900182]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]	CBM complex [GO:0032449]; cytoplasm [GO:0005737]	CARD domain binding [GO:0050700]; signaling receptor complex adaptor activity [GO:0030159]	CBM complex [GO:0032449]; cytoplasm [GO:0005737]; CARD domain binding [GO:0050700]; signaling receptor complex adaptor activity [GO:0030159]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of protein localization to nucleus [GO:1900182]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9BWU1	reviewed	CDK19_HUMAN	Cyclin-dependent kinase 19 (EC 2.7.11.22) (CDC2-related protein kinase 6) (Cell division cycle 2-like protein kinase 6) (Cell division protein kinase 19) (Cyclin-dependent kinase 11) (Death-preventing kinase)	CDK19 CDC2L6 CDK11 KIAA1028	Homo sapiens (Human)	502			cellular response to lipopolysaccharide [GO:0071222]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]	CKM complex [GO:1990508]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	CKM complex [GO:1990508]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cellular response to lipopolysaccharide [GO:0071222]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32330417}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:32330417}. Nucleus {ECO:0000269|PubMed:32330417}.
Q9BWV1	reviewed	BOC_HUMAN	Brother of CDO (Protein BOC)	BOC UNQ604/PRO1190	Homo sapiens (Human)	1114	FUNCTION: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.	MISCELLANEOUS: The C-terminal cytoplasmic domain is not required for the stimulation of myogenesis.	axon guidance [GO:0007411]; cell-cell adhesion [GO:0098609]; nervous system development [GO:0007399]; positive regulation of myoblast differentiation [GO:0045663]	axon [GO:0030424]; axonal growth cone [GO:0044295]; plasma membrane [GO:0005886]		axon [GO:0030424]; axonal growth cone [GO:0044295]; plasma membrane [GO:0005886]; axon guidance [GO:0007411]; cell-cell adhesion [GO:0098609]; nervous system development [GO:0007399]; positive regulation of myoblast differentiation [GO:0045663]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12634428}; Single-pass type I membrane protein {ECO:0000269|PubMed:12634428}. Note=Enriched at sites of cell-cell contact.
Q9BWV3	reviewed	CDAC1_HUMAN	Cytidine and dCMP deaminase domain-containing protein 1 (EC 3.5.4.5) (Cytidine deaminase) (Testis development protein NYD-SP15)	CDADC1	Homo sapiens (Human)	514	FUNCTION: Catalyzes the deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively (PubMed:26945630). May play an important role in testicular development and spermatogenesis (PubMed:16955368). {ECO:0000269|PubMed:16955368, ECO:0000269|PubMed:26945630}.		cytidine deamination [GO:0009972]; DNA cytosine deamination [GO:0070383]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	cytidine deaminase activity [GO:0004126]; importin-alpha family protein binding [GO:0061676]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; cytidine deaminase activity [GO:0004126]; importin-alpha family protein binding [GO:0061676]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; cytidine deamination [GO:0009972]; DNA cytosine deamination [GO:0070383]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:26945630}. Nucleus {ECO:0000305|PubMed:26945630}.
Q9BWV7	reviewed	TTLL2_HUMAN	Probable tubulin polyglutamylase TTLL2 (EC 6.-.-.-) (Testis-specific protein NYD-TSPG) (Tubulin--tyrosine ligase-like protein 2)	TTLL2 C6orf104	Homo sapiens (Human)	592	FUNCTION: Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (By similarity). Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (By similarity). Probably involved in the side-chain initiation step of the polyglutamylation reaction rather than the elongation step (By similarity). {ECO:0000250|UniProtKB:A4Q9E4, ECO:0000250|UniProtKB:Q91V51}.		microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211]	cilium [GO:0005929]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	cilium [GO:0005929]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]; microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211]	
Q9BWW4	reviewed	SSBP3_HUMAN	Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein)	SSBP3 SSDP SSDP1	Homo sapiens (Human)	388	FUNCTION: May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. {ECO:0000250}.		head morphogenesis [GO:0060323]; hematopoietic progenitor cell differentiation [GO:0002244]; mesendoderm development [GO:0048382]; midbrain-hindbrain boundary initiation [GO:0021547]; positive regulation of anterior head development [GO:2000744]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prechordal plate formation [GO:0021501]; protein-containing complex assembly [GO:0065003]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713]; head morphogenesis [GO:0060323]; hematopoietic progenitor cell differentiation [GO:0002244]; mesendoderm development [GO:0048382]; midbrain-hindbrain boundary initiation [GO:0021547]; positive regulation of anterior head development [GO:2000744]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prechordal plate formation [GO:0021501]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9BWW7	reviewed	SCRT1_HUMAN	Transcriptional repressor scratch 1 (Scratch homolog 1 zinc finger protein) (SCRT) (Scratch 1) (hScrt)	SCRT1	Homo sapiens (Human)	348	FUNCTION: Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation. {ECO:0000269|PubMed:11274425}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron migration [GO:2001222]	nuclear body [GO:0016604]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	nuclear body [GO:0016604]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron migration [GO:2001222]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11274425}.
Q9BWX1	reviewed	PHF7_HUMAN	PHD finger protein 7 (Testis development protein NYD-SP6)	PHF7	Homo sapiens (Human)	381	FUNCTION: May play a role in spermatogenesis.			cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11829468}.
Q9BWX5	reviewed	GATA5_HUMAN	Transcription factor GATA-5 (GATA-binding factor 5)	GATA5	Homo sapiens (Human)	397	FUNCTION: Transcription factor required during cardiovascular development (PubMed:23289003). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PubMed:25543888). {ECO:0000250|UniProtKB:P97489, ECO:0000269|PubMed:23289003, ECO:0000269|PubMed:25543888}.		aortic valve morphogenesis [GO:0003180]; cardiac muscle tissue development [GO:0048738]; cell fate commitment [GO:0045165]; cellular response to BMP stimulus [GO:0071773]; endocardial cushion fusion [GO:0003274]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cardiac endothelial to mesenchymal transition [GO:0062000]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway involved in heart induction [GO:0035481]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; aortic valve morphogenesis [GO:0003180]; cardiac muscle tissue development [GO:0048738]; cell fate commitment [GO:0045165]; cellular response to BMP stimulus [GO:0071773]; endocardial cushion fusion [GO:0003274]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cardiac endothelial to mesenchymal transition [GO:0062000]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway involved in heart induction [GO:0035481]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9BX10	reviewed	GTPB2_HUMAN	GTP-binding protein 2	GTPBP2	Homo sapiens (Human)	602			translational elongation [GO:0006414]	extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; translation elongation factor activity [GO:0003746]	extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; translation elongation factor activity [GO:0003746]; translational elongation [GO:0006414]	
Q9BX26	reviewed	SYCP2_HUMAN	Synaptonemal complex protein 2 (SCP-2) (Synaptonemal complex lateral element protein) (hsSCP2)	SYCP2 SCP2	Homo sapiens (Human)	1530	FUNCTION: Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements. {ECO:0000250|UniProtKB:Q9CUU3}.		apoptotic process [GO:0006915]; cell division [GO:0051301]; ectopic germ cell programmed cell death [GO:0035234]; female meiotic nuclear division [GO:0007143]; fertilization [GO:0009566]; male genitalia morphogenesis [GO:0048808]; male meiotic nuclear division [GO:0007140]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of reproductive process [GO:2000242]; synaptonemal complex assembly [GO:0007130]	lateral element [GO:0000800]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]	DNA binding [GO:0003677]	lateral element [GO:0000800]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]; DNA binding [GO:0003677]; apoptotic process [GO:0006915]; cell division [GO:0051301]; ectopic germ cell programmed cell death [GO:0035234]; female meiotic nuclear division [GO:0007143]; fertilization [GO:0009566]; male genitalia morphogenesis [GO:0048808]; male meiotic nuclear division [GO:0007140]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of reproductive process [GO:2000242]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9CUU3}. Chromosome {ECO:0000250|UniProtKB:Q9CUU3}. Note=In axial/lateral elements of the tripartite segments of synaptonemal complexes. {ECO:0000250|UniProtKB:Q9CUU3}.
Q9BX40	reviewed	LS14B_HUMAN	Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B)	LSM14B C20orf40 FAM61B RAP55B	Homo sapiens (Human)	385	FUNCTION: Required for oocyte meiotic maturation. May be involved in the storage of translationally inactive mRNAs and protect them from degradation (By similarity). Plays a role in control of mRNA translation (By similarity). {ECO:0000250|UniProtKB:Q68FI1, ECO:0000250|UniProtKB:Q8CGC4}.		regulation of translation [GO:0006417]	ribonucleoprotein complex [GO:1990904]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	ribonucleoprotein complex [GO:1990904]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; regulation of translation [GO:0006417]	
Q9BX46	reviewed	RBM24_HUMAN	RNA-binding protein 24 (RNA-binding motif protein 24) (RNA-binding region-containing protein 6)	RBM24 RNPC6	Homo sapiens (Human)	236	FUNCTION: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29358667, PubMed:29104163). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed:29104163). Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities (PubMed:20977548, PubMed:24356969). Involved in myogenic differentiation by regulating MYOG levels (PubMed:20977548). Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization (PubMed:24375645). Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence (PubMed:29104163). Plays a role in the regulation of mRNA translation (PubMed:29358667). Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation (PubMed:29358667). Binds to a huge amount of mRNAs (PubMed:29104163). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity). Together with RBM20, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:D3Z4I3, ECO:0000250|UniProtKB:M0R7T6, ECO:0000269|PubMed:20977548, ECO:0000269|PubMed:24356969, ECO:0000269|PubMed:24375645, ECO:0000269|PubMed:26990106, ECO:0000269|PubMed:29104163, ECO:0000269|PubMed:29358667}.; FUNCTION: (Microbial infection) Promotes hepatitis C virus (HCV) replication over translation through the inhibition of viral protein expression. Decreases viral translation by linking viral 5'- and 3'-UTRs, blocking 80S ribosome assembly on the viral IRES and enhancing the interaction of the mature core protein and 5'-UTR. {ECO:0000269|PubMed:29380205}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; cell differentiation [GO:0030154]; DNA damage response [GO:0006974]; endocardial cushion development [GO:0003197]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of cytoplasmic translation [GO:2000766]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of skeletal muscle fiber differentiation [GO:1902811]; positive regulation of stem cell differentiation [GO:2000738]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA stability [GO:0043488]; regulation of myotube differentiation [GO:0010830]; RNA splicing [GO:0008380]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA CDS binding [GO:1990715]; pre-mRNA intronic binding [GO:0097157]; sequence-specific mRNA binding [GO:1990825]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA CDS binding [GO:1990715]; pre-mRNA intronic binding [GO:0097157]; sequence-specific mRNA binding [GO:1990825]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; cell differentiation [GO:0030154]; DNA damage response [GO:0006974]; endocardial cushion development [GO:0003197]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of cytoplasmic translation [GO:2000766]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of skeletal muscle fiber differentiation [GO:1902811]; positive regulation of stem cell differentiation [GO:2000738]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA stability [GO:0043488]; regulation of myotube differentiation [GO:0010830]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6GQD3}. Cytoplasm {ECO:0000250|UniProtKB:D3Z4I3}.
Q9BX59	reviewed	TPSNR_HUMAN	Tapasin-related protein (TAPASIN-R) (TAP-binding protein-like) (TAP-binding protein-related protein) (TAPBP-R) (Tapasin-like)	TAPBPL	Homo sapiens (Human)	468	FUNCTION: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). {ECO:0000269|PubMed:23401559, ECO:0000269|PubMed:26869717}.	MISCELLANEOUS: [Isoform beta]: Has reduced cell surface expression, and does not down-regulate MHC class I surface expression as efficiently as isoform alpha. {ECO:0000305}.; MISCELLANEOUS: [Isoform gamma]: Does not interact with MHC class I. {ECO:0000305}.; MISCELLANEOUS: [Isoform delta]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	negative regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002590]; peptide antigen assembly with MHC class I protein complex [GO:0002502]	endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; MHC class I peptide loading complex [GO:0042824]; plasma membrane [GO:0005886]	MHC class I protein complex binding [GO:0023024]; TAP complex binding [GO:0062061]	endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; MHC class I peptide loading complex [GO:0042824]; plasma membrane [GO:0005886]; MHC class I protein complex binding [GO:0023024]; TAP complex binding [GO:0062061]; negative regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002590]; peptide antigen assembly with MHC class I protein complex [GO:0002502]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Microsome membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Golgi apparatus membrane {ECO:0000269|PubMed:23401559}; Single-pass type I membrane protein {ECO:0000269|PubMed:23401559}. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573).
Q9BX63	reviewed	FANCJ_HUMAN	Fanconi anemia group J protein (Protein FACJ) (EC 3.6.4.13) (ATP-dependent RNA helicase BRIP1) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1)	BRIP1 BACH1 FANCJ	Homo sapiens (Human)	1249	FUNCTION: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896}.		cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to vitamin [GO:0071295]; chiasma assembly [GO:0051026]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair involved in meiotic recombination [GO:1990918]; homologous recombination [GO:0035825]; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; nucleotide-excision repair [GO:0006289]; regulation of transcription by RNA polymerase II [GO:0006357]; response to toxic substance [GO:0009636]; seminiferous tubule development [GO:0072520]; spermatid development [GO:0007286]; spermatogonial cell division [GO:0007284]	BRCA1-B complex [GO:0070532]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; metal ion binding [GO:0046872]; RNA helicase activity [GO:0003724]	BRCA1-B complex [GO:0070532]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; metal ion binding [GO:0046872]; RNA helicase activity [GO:0003724]; cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to vitamin [GO:0071295]; chiasma assembly [GO:0051026]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair involved in meiotic recombination [GO:1990918]; homologous recombination [GO:0035825]; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; nucleotide-excision repair [GO:0006289]; regulation of transcription by RNA polymerase II [GO:0006357]; response to toxic substance [GO:0009636]; seminiferous tubule development [GO:0072520]; spermatid development [GO:0007286]; spermatogonial cell division [GO:0007284]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:23585563}. Cytoplasm {ECO:0000269|PubMed:23585563}.
Q9BX66	reviewed	SRBS1_HUMAN	Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)	SORBS1 KIAA0894 KIAA1296 SH3D5	Homo sapiens (Human)	1292	FUNCTION: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.	MISCELLANEOUS: [Isoform 12]: Derived from mouse ortholog data. {ECO:0000305}.	cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; insulin receptor signaling pathway [GO:0008286]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of protein localization to plasma membrane [GO:1903078]; stress fiber assembly [GO:0043149]	adherens junction [GO:0005912]; cell-substrate junction [GO:0030055]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; zonula adherens [GO:0005915]	actin binding [GO:0003779]; cytoskeletal protein binding [GO:0008092]; insulin receptor binding [GO:0005158]; signaling receptor complex adaptor activity [GO:0030159]	adherens junction [GO:0005912]; cell-substrate junction [GO:0030055]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; zonula adherens [GO:0005915]; actin binding [GO:0003779]; cytoskeletal protein binding [GO:0008092]; insulin receptor binding [GO:0005158]; signaling receptor complex adaptor activity [GO:0030159]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; insulin receptor signaling pathway [GO:0008286]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of protein localization to plasma membrane [GO:1903078]; stress fiber assembly [GO:0043149]	SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus {ECO:0000250}. Nucleus matrix {ECO:0000250}. Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation. {ECO:0000250}.
Q9BX67	reviewed	JAM3_HUMAN	Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)]	JAM3 UNQ859/PRO1868	Homo sapiens (Human)	310	FUNCTION: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:11590146, PubMed:11823489). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084). Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity). {ECO:0000250|UniProtKB:A3KPA0, ECO:0000250|UniProtKB:Q9D8B7, ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:11823489, ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:23255084, ECO:0000269|PubMed:24357068, ECO:0000305|PubMed:28196865}.; FUNCTION: [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis. {ECO:0000269|PubMed:20592283}.		adaptive immune response [GO:0002250]; adherens junction assembly [GO:0034333]; angiogenesis [GO:0001525]; apical protein localization [GO:0045176]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; establishment of cell polarity [GO:0030010]; granulocyte migration [GO:0097530]; hematopoietic stem cell migration to bone marrow [GO:0097241]; heterotypic cell-cell adhesion [GO:0034113]; leukocyte migration involved in inflammatory response [GO:0002523]; maintenance of blood-brain barrier [GO:0035633]; myelination [GO:0042552]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of integrin activation [GO:0033624]; neutrophil homeostasis [GO:0001780]; positive regulation of membrane permeability [GO:1905710]; positive regulation of monocyte extravasation [GO:2000439]; protein localization to cell junction [GO:1902414]; protein localization to cell surface [GO:0034394]; regulation of actin cytoskeleton organization by cell-cell adhesion [GO:0090138]; regulation of neutrophil chemotaxis [GO:0090022]; spermatid development [GO:0007286]; transmission of nerve impulse [GO:0019226]	bicellular tight junction [GO:0005923]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; desmosome [GO:0030057]; extracellular space [GO:0005615]; filamentous actin [GO:0031941]; Golgi apparatus [GO:0005794]; microvillus [GO:0005902]; paranodal junction [GO:0033010]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160]	cell-cell adhesion mediator activity [GO:0098632]; integrin binding [GO:0005178]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	bicellular tight junction [GO:0005923]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; desmosome [GO:0030057]; extracellular space [GO:0005615]; filamentous actin [GO:0031941]; Golgi apparatus [GO:0005794]; microvillus [GO:0005902]; paranodal junction [GO:0033010]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160]; cell-cell adhesion mediator activity [GO:0098632]; integrin binding [GO:0005178]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; adaptive immune response [GO:0002250]; adherens junction assembly [GO:0034333]; angiogenesis [GO:0001525]; apical protein localization [GO:0045176]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; establishment of cell polarity [GO:0030010]; granulocyte migration [GO:0097530]; hematopoietic stem cell migration to bone marrow [GO:0097241]; heterotypic cell-cell adhesion [GO:0034113]; leukocyte migration involved in inflammatory response [GO:0002523]; maintenance of blood-brain barrier [GO:0035633]; myelination [GO:0042552]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of integrin activation [GO:0033624]; neutrophil homeostasis [GO:0001780]; positive regulation of membrane permeability [GO:1905710]; positive regulation of monocyte extravasation [GO:2000439]; protein localization to cell junction [GO:1902414]; protein localization to cell surface [GO:0034394]; regulation of actin cytoskeleton organization by cell-cell adhesion [GO:0090138]; regulation of neutrophil chemotaxis [GO:0090022]; spermatid development [GO:0007286]; transmission of nerve impulse [GO:0019226]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15994945, ECO:0000269|PubMed:23255084, ECO:0000269|PubMed:28196865}; Single-pass type I membrane protein {ECO:0000305|PubMed:11590146}. Cell junction {ECO:0000269|PubMed:15994945}. Cell junction, desmosome {ECO:0000269|PubMed:15194813}. Cell junction, tight junction {ECO:0000269|PubMed:28196865}. Note=Detected in the acrosome region in developing spermatids (By similarity). In epithelial cells, it is expressed at desmosomes but not at tight junctions (PubMed:15194813). Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (PubMed:15994945). {ECO:0000250|UniProtKB:Q9D8B7}.; SUBCELLULAR LOCATION: [Soluble form of JAM-C]: Secreted {ECO:0000269|PubMed:20592283}.
Q9BX68	reviewed	HINT2_HUMAN	Adenosine 5'-monophosphoramidase HINT2 (EC 3.9.1.-) (HINT-3) (HIT-17kDa) (Histidine triad nucleotide-binding protein 2, mitochondrial) (HINT-2) (PKCI-1-related HIT protein)	HINT2	Homo sapiens (Human)	163	FUNCTION: Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367). May be involved in steroid biosynthesis (PubMed:18653718). May play a role in apoptosis (PubMed:16762638). {ECO:0000269|PubMed:16762638, ECO:0000269|PubMed:18653718, ECO:0000269|PubMed:31990367}.		apoptotic process [GO:0006915]; lipid catabolic process [GO:0016042]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; steroid biosynthetic process [GO:0006694]	cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	adenosine 5'-monophosphoramidase activity [GO:0043530]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166]	cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; adenosine 5'-monophosphoramidase activity [GO:0043530]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166]; apoptotic process [GO:0006915]; lipid catabolic process [GO:0016042]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; steroid biosynthetic process [GO:0006694]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16762638, ECO:0000269|PubMed:18653718}.
Q9BX70	reviewed	BTBD2_HUMAN	BTB/POZ domain-containing protein 2	BTBD2	Homo sapiens (Human)	525			neurogenesis [GO:0022008]	cytosol [GO:0005829]; P-body [GO:0000932]		cytosol [GO:0005829]; P-body [GO:0000932]; neurogenesis [GO:0022008]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12878161}. Note=Localizes to punctate or elongated cytoplasmic bodies. {ECO:0000269|PubMed:12878161}.
Q9BX74	reviewed	TM2D1_HUMAN	TM2 domain-containing protein 1 (Amyloid-beta-binding protein) (hBBP)	TM2D1 BBP	Homo sapiens (Human)	207	FUNCTION: May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42. {ECO:0000269|PubMed:11278849, ECO:0000269|PubMed:12836168}.		apoptotic signaling pathway [GO:0097190]	plasma membrane [GO:0005886]	amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930]; apoptotic signaling pathway [GO:0097190]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11278849}; Multi-pass membrane protein {ECO:0000269|PubMed:11278849}.
Q9BX79	reviewed	STRA6_HUMAN	Receptor for retinol uptake STRA6 (Retinol-binding protein receptor STRA6) (Stimulated by retinoic acid gene 6 protein homolog)	STRA6 PP14296 UNQ3126/PRO10282/PRO19578	Homo sapiens (Human)	667	FUNCTION: Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:9452451, PubMed:18316031, PubMed:22665496). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031). {ECO:0000269|PubMed:18316031, ECO:0000269|PubMed:21901792, ECO:0000269|PubMed:22665496, ECO:0000269|PubMed:9452451, ECO:0000305}.		adrenal gland development [GO:0030325]; alveolar primary septum development [GO:0061143]; artery morphogenesis [GO:0048844]; blood vessel development [GO:0001568]; camera-type eye development [GO:0043010]; cognition [GO:0050890]; developmental growth [GO:0048589]; diaphragm development [GO:0060539]; digestive tract morphogenesis [GO:0048546]; ductus arteriosus closure [GO:0097070]; ear development [GO:0043583]; embryonic camera-type eye formation [GO:0060900]; embryonic digestive tract development [GO:0048566]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; feeding behavior [GO:0007631]; female genitalia development [GO:0030540]; head development [GO:0060322]; head morphogenesis [GO:0060323]; heart development [GO:0007507]; kidney development [GO:0001822]; learning [GO:0007612]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung vasculature development [GO:0060426]; neuromuscular process [GO:0050905]; nose morphogenesis [GO:0043585]; paramesonephric duct development [GO:0061205]; positive regulation of behavior [GO:0048520]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; retinol transport [GO:0034633]; smooth muscle tissue development [GO:0048745]; uterus morphogenesis [GO:0061038]; ventricular septum development [GO:0003281]; vitamin A import into cell [GO:0071939]; vocal learning [GO:0042297]	plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	retinal binding [GO:0016918]; retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; retinal binding [GO:0016918]; retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632]; signaling receptor activity [GO:0038023]; adrenal gland development [GO:0030325]; alveolar primary septum development [GO:0061143]; artery morphogenesis [GO:0048844]; blood vessel development [GO:0001568]; camera-type eye development [GO:0043010]; cognition [GO:0050890]; developmental growth [GO:0048589]; diaphragm development [GO:0060539]; digestive tract morphogenesis [GO:0048546]; ductus arteriosus closure [GO:0097070]; ear development [GO:0043583]; embryonic camera-type eye formation [GO:0060900]; embryonic digestive tract development [GO:0048566]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; feeding behavior [GO:0007631]; female genitalia development [GO:0030540]; head development [GO:0060322]; head morphogenesis [GO:0060323]; heart development [GO:0007507]; kidney development [GO:0001822]; learning [GO:0007612]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung vasculature development [GO:0060426]; neuromuscular process [GO:0050905]; nose morphogenesis [GO:0043585]; paramesonephric duct development [GO:0061205]; positive regulation of behavior [GO:0048520]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; retinol transport [GO:0034633]; smooth muscle tissue development [GO:0048745]; uterus morphogenesis [GO:0061038]; ventricular septum development [GO:0003281]; vitamin A import into cell [GO:0071939]; vocal learning [GO:0042297]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18316031, ECO:0000269|PubMed:21901792, ECO:0000269|PubMed:9452451}; Multi-pass membrane protein {ECO:0000305}. Note=In the retinal pigment epithelium localizes to the basolateral membrane. {ECO:0000250|UniProtKB:Q0V8E7}.
Q9BX84	reviewed	TRPM6_HUMAN	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6)	TRPM6 CHAK2	Homo sapiens (Human)	2022	FUNCTION: Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.	MISCELLANEOUS: [Isoform M6-kinase 1]: Lacks the ion channel region. {ECO:0000305}.; MISCELLANEOUS: [Isoform M6-kinase 2]: Lacks the ion channel region. {ECO:0000305}.; MISCELLANEOUS: [Isoform M6-kinase 3]: Lacks the ion channel region. {ECO:0000305}.	calcium ion transmembrane transport [GO:0070588]; monoatomic cation transmembrane transport [GO:0098655]; phosphorylation [GO:0016310]; protein tetramerization [GO:0051262]; response to toxic substance [GO:0009636]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; metal ion binding [GO:0046872]; monoatomic cation channel activity [GO:0005261]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; metal ion binding [GO:0046872]; monoatomic cation channel activity [GO:0005261]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; calcium ion transmembrane transport [GO:0070588]; monoatomic cation transmembrane transport [GO:0098655]; phosphorylation [GO:0016310]; protein tetramerization [GO:0051262]; response to toxic substance [GO:0009636]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23942199}; Multi-pass membrane protein.
Q9BX95	reviewed	SGPP1_HUMAN	Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1)	SGPP1 SPP1	Homo sapiens (Human)	441	FUNCTION: Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:12815058, PubMed:11756451, PubMed:16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:11756451, PubMed:12815058, PubMed:16782891). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (PubMed:16782891). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:20798685, PubMed:18583713). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q9JI99, ECO:0000269|PubMed:11756451, ECO:0000269|PubMed:12815058, ECO:0000269|PubMed:16782891, ECO:0000269|PubMed:18583713, ECO:0000269|PubMed:20798685}.		ER to Golgi ceramide transport [GO:0035621]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; phospholipid dephosphorylation [GO:0046839]; regulation of epidermis development [GO:0045682]; regulation of keratinocyte differentiation [GO:0045616]; sphinganine-1-phosphate metabolic process [GO:0006668]; sphingolipid biosynthetic process [GO:0030148]; sphingosine metabolic process [GO:0006670]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	dihydrosphingosine-1-phosphate phosphatase activity [GO:0070780]; sphingosine-1-phosphate phosphatase activity [GO:0042392]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; dihydrosphingosine-1-phosphate phosphatase activity [GO:0070780]; sphingosine-1-phosphate phosphatase activity [GO:0042392]; ER to Golgi ceramide transport [GO:0035621]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; phospholipid dephosphorylation [GO:0046839]; regulation of epidermis development [GO:0045682]; regulation of keratinocyte differentiation [GO:0045616]; sphinganine-1-phosphate metabolic process [GO:0006668]; sphingolipid biosynthetic process [GO:0030148]; sphingosine metabolic process [GO:0006670]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12815058}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9JI99}; Multi-pass membrane protein {ECO:0000255}.
Q9BX97	reviewed	PLVAP_HUMAN	Plasmalemma vesicle-associated protein (Fenestrated endothelial-linked structure protein) (Plasmalemma vesicle protein 1) (PV-1)	PLVAP FELS PV1	Homo sapiens (Human)	442	FUNCTION: Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. {ECO:0000250|UniProtKB:Q91VC4}.		developmental process [GO:0032502]; MAPK cascade [GO:0000165]; positive regulation of cellular extravasation [GO:0002693]; regulation of vascular permeability [GO:0043114]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	caveola [GO:0005901]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]	identical protein binding [GO:0042802]	caveola [GO:0005901]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; identical protein binding [GO:0042802]; developmental process [GO:0032502]; MAPK cascade [GO:0000165]; positive regulation of cellular extravasation [GO:0002693]; regulation of vascular permeability [GO:0043114]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9WV78}; Single-pass type II membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:Q9WV78}; Single-pass type II membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9WV78}. Note=Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region. {ECO:0000250|UniProtKB:Q9WV78}.
Q9BXA5	reviewed	SUCR1_HUMAN	Succinate receptor 1 (G-protein coupled receptor 91) (P2Y purinoceptor 1-like)	SUCNR1 GPR91	Homo sapiens (Human)	334	FUNCTION: G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (By similarity) (PubMed:15141213, PubMed:34133934, PubMed:23770096). Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasis (PubMed:18820681, PubMed:34133934). In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells (By similarity). Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involoved in immune function (PubMed:34133934). In activated M1 macrophages, plays a pro-inflammatory role in response to LPS (By similarity). Expressed in dendritic cells, where it is involved in the sensing of immunological danger and enhances immunity. Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well as an enhancement of antigen-specific activation of helper T cells (PubMed:18820681). In the small intestine, mediates the activation of tuft cells by dietary succinate and triggers type 2 immunity (By similarity). In adipocytes, plays an important role in the control of energy metabolism. In response to succinate, controls leptin expression in an AMPK-JNK-CEBPA-dependent as well as circadian clock-regulated manner (By similarity). In muscle tissue, is expressed in non-muscle cells and coordinates muscle remodeling in response to the succinate produced during exercise training in a paracrine manner (By similarity). In retina, acts as a mediator of vessel growth during retinal development. In response to succinate, regulates the production of angiogenic factors, including VEGF, by retinal ganglion neurons (By similarity). {ECO:0000250|UniProtKB:Q6IYF9, ECO:0000250|UniProtKB:Q99MT6, ECO:0000269|PubMed:15141213, ECO:0000269|PubMed:18820681, ECO:0000269|PubMed:23770096, ECO:0000269|PubMed:34133934}.		G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; macrophage activation involved in immune response [GO:0002281]; positive regulation of chemotaxis [GO:0050921]; positive regulation of inflammatory response [GO:0050729]; regulation of angiotensin metabolic process [GO:0060177]; renin secretion into blood stream [GO:0002001]; response to calcium ion [GO:0051592]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; macrophage activation involved in immune response [GO:0002281]; positive regulation of chemotaxis [GO:0050921]; positive regulation of inflammatory response [GO:0050729]; regulation of angiotensin metabolic process [GO:0060177]; renin secretion into blood stream [GO:0002001]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15141213}; Multi-pass membrane protein {ECO:0000269|PubMed:15141213}.
Q9BXA6	reviewed	TSSK6_HUMAN	Testis-specific serine/threonine-protein kinase 6 (TSK-6) (TSSK-6) (Testis-specific kinase 6) (EC 2.7.11.1) (Cancer/testis antigen 72) (CT72) (Serine/threonine-protein kinase SSTK) (Small serine/threonine kinase)	TSSK6 SSTK FKSG82	Homo sapiens (Human)	273	FUNCTION: Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). {ECO:0000250|UniProtKB:Q925K9, ECO:0000269|PubMed:15870294}.		cellular response to glucose starvation [GO:0042149]; intracellular signal transduction [GO:0035556]; negative regulation of TOR signaling [GO:0032007]; protein phosphorylation [GO:0006468]; sperm DNA condensation [GO:0035092]	nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; cellular response to glucose starvation [GO:0042149]; intracellular signal transduction [GO:0035556]; negative regulation of TOR signaling [GO:0032007]; protein phosphorylation [GO:0006468]; sperm DNA condensation [GO:0035092]	
Q9BXA7	reviewed	TSSK1_HUMAN	Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) (Serine/threonine-protein kinase 22A)	TSSK1B SPOGA1 SPOGA4 STK22A STK22D TSSK1 FKSG81	Homo sapiens (Human)	367	FUNCTION: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:19530700}.	MISCELLANEOUS: TSSK1B might be used as a target for male contraception or and intra-vaginal spermicides. {ECO:0000305|PubMed:17566264}.	cellular response to glucose starvation [GO:0042149]; intracellular signal transduction [GO:0035556]; negative regulation of TOR signaling [GO:0032007]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286]	acrosomal vesicle [GO:0001669]; motile cilium [GO:0031514]; nucleotide-activated protein kinase complex [GO:0031588]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; motile cilium [GO:0031514]; nucleotide-activated protein kinase complex [GO:0031588]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; cellular response to glucose starvation [GO:0042149]; intracellular signal transduction [GO:0035556]; negative regulation of TOR signaling [GO:0032007]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000250}. Note=In spermatozoa, present in the sperm head and in the flagellum. {ECO:0000250}.
Q9BXB1	reviewed	LGR4_HUMAN	Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48)	LGR4 GPR48	Homo sapiens (Human)	951	FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity). Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (By similarity). {ECO:0000250|UniProtKB:A2ARI4, ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23444378, ECO:0000269|PubMed:23756652}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone mineralization [GO:0030282]; bone remodeling [GO:0046849]; canonical Wnt signaling pathway involved in metanephric kidney development [GO:0061290]; cell differentiation involved in metanephros development [GO:0072202]; circadian regulation of gene expression [GO:0032922]; digestive tract development [GO:0048565]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; hair follicle development [GO:0001942]; innate immune response [GO:0045087]; intestinal stem cell homeostasis [GO:0036335]; male genitalia development [GO:0030539]; metanephric glomerulus development [GO:0072224]; metanephric nephron tubule morphogenesis [GO:0072282]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of cytokine production [GO:0001818]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; osteoblast differentiation [GO:0001649]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; spermatogenesis [GO:0007283]	plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; protein-hormone receptor activity [GO:0016500]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; protein-hormone receptor activity [GO:0016500]; transmembrane signaling receptor activity [GO:0004888]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone mineralization [GO:0030282]; bone remodeling [GO:0046849]; canonical Wnt signaling pathway involved in metanephric kidney development [GO:0061290]; cell differentiation involved in metanephros development [GO:0072202]; circadian regulation of gene expression [GO:0032922]; digestive tract development [GO:0048565]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; hair follicle development [GO:0001942]; innate immune response [GO:0045087]; intestinal stem cell homeostasis [GO:0036335]; male genitalia development [GO:0030539]; metanephric glomerulus development [GO:0072224]; metanephric nephron tubule morphogenesis [GO:0072282]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of cytokine production [GO:0001818]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; osteoblast differentiation [GO:0001649]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:22815884}; Multi-pass membrane protein {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:22815884}.
Q9BXB4	reviewed	OSB11_HUMAN	Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11)	OSBPL11 ORP11 OSBP12	Homo sapiens (Human)	747	FUNCTION: Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:23028956}.		fat cell differentiation [GO:0045444]; positive regulation of sequestering of triglyceride [GO:0010890]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	sterol binding [GO:0032934]; sterol transporter activity [GO:0015248]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; sterol binding [GO:0032934]; sterol transporter activity [GO:0015248]; fat cell differentiation [GO:0045444]; positive regulation of sequestering of triglyceride [GO:0010890]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:20599956}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:20599956}. Note=Localizes at the Golgi-late endosome interface.
Q9BXB5	reviewed	OSB10_HUMAN	Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10)	OSBPL10 ORP10 OSBP9	Homo sapiens (Human)	764	FUNCTION: Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}.		phosphatidylserine acyl-chain remodeling [GO:0036150]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	cholesterol binding [GO:0015485]; phosphatidylserine binding [GO:0001786]; phospholipid transporter activity [GO:0005548]; sterol transporter activity [GO:0015248]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; cholesterol binding [GO:0015485]; phosphatidylserine binding [GO:0001786]; phospholipid transporter activity [GO:0005548]; sterol transporter activity [GO:0015248]; phosphatidylserine acyl-chain remodeling [GO:0036150]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437}. Note=Associates with microtubules. {ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437}.
Q9BXB7	reviewed	SPT16_HUMAN	Spermatogenesis-associated protein 16 (Testis development protein NYD-SP12)	SPATA16	Homo sapiens (Human)	569	FUNCTION: Essential for spermiogenesis and male fertility (By similarity). Involved in the formation of sperm acrosome during spermatogenesis. {ECO:0000250|UniProtKB:Q8C636, ECO:0000269|PubMed:12529416}.	MISCELLANEOUS: Association analysis reveals significant frequency of a synonymous (Ser-225) sequence polymorphism among clinical groups with different sperm traits: the donor group, which has the highest sperm count and motility level, has a significant higher polymorphism frequency compared to normal and asthenozoopermia groups.	spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]; Golgi apparatus [GO:0005794]		acrosomal vesicle [GO:0001669]; Golgi apparatus [GO:0005794]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:12529416}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8C636}. Note=Shift from Golgi to sperm acrosome. {ECO:0000250|UniProtKB:Q8C636}.
Q9BXC0	reviewed	HCAR1_HUMAN	Hydroxycarboxylic acid receptor 1 (G-protein coupled receptor 104) (G-protein coupled receptor 81)	HCAR1 GPR104 GPR81 HCA1 FKSG80	Homo sapiens (Human)	346	FUNCTION: Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway. {ECO:0000269|PubMed:19047060}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of lipid catabolic process [GO:0050995]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of lipid catabolic process [GO:0050995]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9BXC9	reviewed	BBS2_HUMAN	Bardet-Biedl syndrome 2 protein	BBS2	Homo sapiens (Human)	721	FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.		adult behavior [GO:0030534]; artery smooth muscle contraction [GO:0014824]; brain morphogenesis [GO:0048854]; cartilage development [GO:0051216]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; fat cell differentiation [GO:0045444]; gene expression [GO:0010467]; Golgi to plasma membrane protein transport [GO:0043001]; hippocampus development [GO:0021766]; melanosome transport [GO:0032402]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; positive regulation of multicellular organism growth [GO:0040018]; protein localization [GO:0008104]; protein localization to organelle [GO:0033365]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; sperm axoneme assembly [GO:0007288]; striatum development [GO:0021756]; vasodilation [GO:0042311]; visual perception [GO:0007601]	BBSome [GO:0034464]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; membrane [GO:0016020]; microvillus [GO:0005902]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; stereocilium [GO:0032420]	RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	BBSome [GO:0034464]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; membrane [GO:0016020]; microvillus [GO:0005902]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; stereocilium [GO:0032420]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; adult behavior [GO:0030534]; artery smooth muscle contraction [GO:0014824]; brain morphogenesis [GO:0048854]; cartilage development [GO:0051216]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; fat cell differentiation [GO:0045444]; gene expression [GO:0010467]; Golgi to plasma membrane protein transport [GO:0043001]; hippocampus development [GO:0021766]; melanosome transport [GO:0032402]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; positive regulation of multicellular organism growth [GO:0040018]; protein localization [GO:0008104]; protein localization to organelle [GO:0033365]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; sperm axoneme assembly [GO:0007288]; striatum development [GO:0021756]; vasodilation [GO:0042311]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Q9BXD5	reviewed	NPL_HUMAN	N-acetylneuraminate lyase (NALase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase)	NPL C1orf13	Homo sapiens (Human)	320	FUNCTION: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (PubMed:33895133). It prevents sialic acids from being recycled and returning to the cell surface (PubMed:33895133). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (PubMed:22692205, PubMed:33895133). Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (Probable). {ECO:0000269|PubMed:22692205, ECO:0000269|PubMed:33895133, ECO:0000305|PubMed:22692205}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	carbohydrate metabolic process [GO:0005975]; N-acetylneuraminate catabolic process [GO:0019262]	cytosol [GO:0005829]	identical protein binding [GO:0042802]; N-acetylneuraminate lyase activity [GO:0008747]	cytosol [GO:0005829]; identical protein binding [GO:0042802]; N-acetylneuraminate lyase activity [GO:0008747]; carbohydrate metabolic process [GO:0005975]; N-acetylneuraminate catabolic process [GO:0019262]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9BXF3	reviewed	CECR2_HUMAN	Chromatin remodeling regulator CECR2 (Cat eye syndrome critical region protein 2)	CECR2 KIAA1740	Homo sapiens (Human)	1484	FUNCTION: Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:15640247, PubMed:26365797, PubMed:28801535, PubMed:22464331). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex (PubMed:28801535). Plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797, PubMed:22464331). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed:11827465). {ECO:0000250|UniProtKB:E9Q2Z1, ECO:0000269|PubMed:11827465, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797, ECO:0000269|PubMed:28801535}.	MISCELLANEOUS: Candidate gene for the Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. Duplication usually takes in the form of a surpernumerary bisatellited isodicentric chromosome, resulting in four copies of the region (represents an inv dup(22)(q11)). CES is characterized clinically by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development. {ECO:0000305|PubMed:11381032}.	apoptotic DNA fragmentation [GO:0006309]; chromatin remodeling [GO:0006338]; cochlea development [GO:0090102]; cytoskeleton organization [GO:0007010]; cytoskeleton-dependent cytokinesis [GO:0061640]; execution phase of apoptosis [GO:0097194]; inner ear receptor cell stereocilium organization [GO:0060122]; neural fold formation [GO:0001842]; neural tube closure [GO:0001843]; single fertilization [GO:0007338]; vesicle-mediated transport [GO:0016192]	CERF complex [GO:0090537]; euchromatin [GO:0000791]; nucleus [GO:0005634]	ATP-dependent chromatin remodeler activity [GO:0140658]	CERF complex [GO:0090537]; euchromatin [GO:0000791]; nucleus [GO:0005634]; ATP-dependent chromatin remodeler activity [GO:0140658]; apoptotic DNA fragmentation [GO:0006309]; chromatin remodeling [GO:0006338]; cochlea development [GO:0090102]; cytoskeleton organization [GO:0007010]; cytoskeleton-dependent cytokinesis [GO:0061640]; execution phase of apoptosis [GO:0097194]; inner ear receptor cell stereocilium organization [GO:0060122]; neural fold formation [GO:0001842]; neural tube closure [GO:0001843]; single fertilization [GO:0007338]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309}.
Q9BXF6	reviewed	RFIP5_HUMAN	Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11)	RAB11FIP5 GAF1 KIAA0857 RIP11	Homo sapiens (Human)	653	FUNCTION: Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}.	MISCELLANEOUS: Antibodies against RIP11 are found in sera from patients with autoimmune diseases such as systemic lupus erythematosus (SLE) or Sjoegren syndrome (SS). It is also found in the sera from mothers of children with neonatal lupus erythematosus (NLE).	cellular response to acidic pH [GO:0071468]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; negative regulation of adiponectin secretion [GO:0070164]; regulated exocytosis [GO:0045055]; regulation of protein localization to cell surface [GO:2000008]	centriolar satellite [GO:0034451]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule [GO:0030141]; transport vesicle membrane [GO:0030658]	gamma-tubulin binding [GO:0043015]; small GTPase binding [GO:0031267]	centriolar satellite [GO:0034451]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule [GO:0030141]; transport vesicle membrane [GO:0030658]; gamma-tubulin binding [GO:0043015]; small GTPase binding [GO:0031267]; cellular response to acidic pH [GO:0071468]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; negative regulation of adiponectin secretion [GO:0070164]; regulated exocytosis [GO:0045055]; regulation of protein localization to cell surface [GO:2000008]	SUBCELLULAR LOCATION: Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion membrane; Peripheral membrane protein.
Q9BXF9	reviewed	TEKT3_HUMAN	Tektin-3	TEKT3	Homo sapiens (Human)	490	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme (PubMed:36191189). Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Required for normal sperm mobility (By similarity). {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q6X6Z7, ECO:0000269|PubMed:36191189}.		cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317]; regulation of brood size [GO:0060378]	acrosomal membrane [GO:0002080]; axonemal microtubule [GO:0005879]; extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; outer acrosomal membrane [GO:0002081]; sperm flagellum [GO:0036126]		acrosomal membrane [GO:0002080]; axonemal microtubule [GO:0005879]; extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; outer acrosomal membrane [GO:0002081]; sperm flagellum [GO:0036126]; cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317]; regulation of brood size [GO:0060378]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:36708031}. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q4V8G8}. Note=In spermatozoa, preferentially localizes to the flagella, but also found in the head (PubMed:36708031). In the sperm flagellum, localizes to the periaxonemal region where it associates with the mitochondrial sheath and outer dense fibers (By similarity). Not detected in the central axonemal region of the flagellum (By similarity). Associates with the acrosome membrane in the equatorial segment of the sperm head (By similarity). Also detected just below the plasma membrane in the post-acrosomal region where it might localize to the postacrosomal dense lamina (By similarity). However, other studies report little or no expression in the postacrosomal region (By similarity). Translocates from the postacrosomal region to the equatorial segment after sperm activation (By similarity). Retained in the postacromal region, but not the equatorial segment, following the acrosome reaction (By similarity). Some studies report strong expression in the anterior cap region (By similarity). However, other studies report little or no expression in the acrosomal cap (By similarity). {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8, ECO:0000269|PubMed:36708031}.
Q9BXH1	reviewed	BBC3_HUMAN	Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis)	BBC3 PUMA	Homo sapiens (Human)	193	FUNCTION: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity). {ECO:0000250|UniProtKB:Q99ML1, ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:23340338}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of growth [GO:0045926]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein homooligomerization [GO:0032464]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of thymocyte apoptotic process [GO:0070245]; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:0001844]; release of cytochrome c from mitochondria [GO:0001836]; release of sequestered calcium ion into cytosol [GO:0051209]; response to endoplasmic reticulum stress [GO:0034976]; T cell apoptotic process [GO:0070231]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of growth [GO:0045926]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein homooligomerization [GO:0032464]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of thymocyte apoptotic process [GO:0070245]; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:0001844]; release of cytochrome c from mitochondria [GO:0001836]; release of sequestered calcium ion into cytosol [GO:0051209]; response to endoplasmic reticulum stress [GO:0034976]; T cell apoptotic process [GO:0070231]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:11463392, ECO:0000269|PubMed:11572983}. Note=Localized to the mitochondria in order to induce cytochrome c release.
Q9BXI2	reviewed	ORNT2_HUMAN	Mitochondrial ornithine transporter 2 (Solute carrier family 25 member 2)	SLC25A2 ORC2 ORNT2	Homo sapiens (Human)	301	FUNCTION: Mitochondrial transporter of the positively charged amino acids ornithine, lysine and arginine, and the neutral amino acid citrulline (PubMed:12807890). In addition, transports the basic amino acids histidine, homoarginine, and asymmetric dimethylarginine (aDMA), but not symmetric DMA, and the D-forms of lysine, arginine, ornithine and histidine (PubMed:26403849, PubMed:12807890). Functions by both counter-exchange and uniport mechanisms (PubMed:26403849). {ECO:0000269|PubMed:12807890, ECO:0000269|PubMed:26403849}.	MISCELLANEOUS: In mice, SLC25A2/ORNT2 is a pseudogene. {ECO:0000305}.	L-arginine transmembrane transport [GO:1903826]; L-lysine transmembrane transport [GO:1903401]; L-ornithine transmembrane transport [GO:1903352]; mitochondrial L-ornithine transmembrane transport [GO:1990575]; ornithine metabolic process [GO:0006591]; urea cycle [GO:0000050]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	antiporter activity [GO:0015297]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; antiporter activity [GO:0015297]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]; L-arginine transmembrane transport [GO:1903826]; L-lysine transmembrane transport [GO:1903401]; L-ornithine transmembrane transport [GO:1903352]; mitochondrial L-ornithine transmembrane transport [GO:1990575]; ornithine metabolic process [GO:0006591]; urea cycle [GO:0000050]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:12948741}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q9BXI3	reviewed	5NT1A_HUMAN	Cytosolic 5'-nucleotidase 1A (cN1A) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.99) (5'-deoxynucleotidase) (Cytosolic 5'-nucleotidase IA) (cN-I) (cN-IA)	NT5C1A	Homo sapiens (Human)	368	FUNCTION: Catalyzes the hydrolysis of ribonucleotide and deoxyribonucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (PubMed:11133996, PubMed:7599155, PubMed:8967393, PubMed:34814800). AMP is the major substrate but can also hydrolyze dCMP and IMP (PubMed:11133996, PubMed:7599155, PubMed:8967393, PubMed:34814800). {ECO:0000269|PubMed:11133996, ECO:0000269|PubMed:34814800, ECO:0000269|PubMed:7599155, ECO:0000269|PubMed:8967393}.		adenosine metabolic process [GO:0046085]; allantoin metabolic process [GO:0000255]; AMP catabolic process [GO:0006196]; dAMP catabolic process [GO:0046059]; dGMP catabolic process [GO:0046055]; IMP catabolic process [GO:0006204]; nucleoside metabolic process [GO:0009116]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	5'-nucleotidase activity [GO:0008253]; IMP 5'-nucleotidase activity [GO:0050483]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; XMP 5'-nucleosidase activity [GO:0106411]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; 5'-nucleotidase activity [GO:0008253]; IMP 5'-nucleotidase activity [GO:0050483]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; XMP 5'-nucleosidase activity [GO:0106411]; adenosine metabolic process [GO:0046085]; allantoin metabolic process [GO:0000255]; AMP catabolic process [GO:0006196]; dAMP catabolic process [GO:0046059]; dGMP catabolic process [GO:0046055]; IMP catabolic process [GO:0006204]; nucleoside metabolic process [GO:0009116]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:7599155}.
Q9BXI6	reviewed	TB10A_HUMAN	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha)	TBC1D10A EPI64 TBC1D10	Homo sapiens (Human)	508	FUNCTION: Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A. {ECO:0000269|PubMed:16923811}.		activation of cysteine-type endopeptidase activity [GO:0097202]; positive regulation of proteolysis [GO:0045862]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; activation of cysteine-type endopeptidase activity [GO:0097202]; positive regulation of proteolysis [GO:0045862]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cell projection, microvillus {ECO:0000269|PubMed:16923811}. Note=Localizes to the microvilli-rich region of the syncytiotrophoblast. In melanocytes, located at the periphery of cells.
Q9BXI9	reviewed	C1QT6_HUMAN	Complement C1q tumor necrosis factor-related protein 6	C1QTNF6 CTRP6 UNQ581/PRO1151	Homo sapiens (Human)	278				collagen trimer [GO:0005581]; extracellular space [GO:0005615]	identical protein binding [GO:0042802]	collagen trimer [GO:0005581]; extracellular space [GO:0005615]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BXJ0	reviewed	C1QT5_HUMAN	Complement C1q tumor necrosis factor-related protein 5	C1QTNF5 CTRP5 UNQ303/PRO344	Homo sapiens (Human)	243		MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the MFRP protein from a non-overlapping reading frame.	inner ear development [GO:0048839]; protein secretion [GO:0009306]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell projection [GO:0042995]; collagen trimer [GO:0005581]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]	identical protein binding [GO:0042802]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell projection [GO:0042995]; collagen trimer [GO:0005581]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; identical protein binding [GO:0042802]; inner ear development [GO:0048839]; protein secretion [GO:0009306]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BXJ1	reviewed	C1QT1_HUMAN	Complement C1q tumor necrosis factor-related protein 1 (G protein-coupled receptor-interacting protein) (GIP)	C1QTNF1 CTRP1 UNQ310/PRO353	Homo sapiens (Human)	281			negative regulation of platelet activation [GO:0010544]; negative regulation of platelet aggregation [GO:0090331]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of glucose metabolic process [GO:0010906]	collagen trimer [GO:0005581]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]	collagen trimer [GO:0005581]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; collagen binding [GO:0005518]; identical protein binding [GO:0042802]; negative regulation of platelet activation [GO:0010544]; negative regulation of platelet aggregation [GO:0090331]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; regulation of glucose metabolic process [GO:0010906]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BXJ3	reviewed	C1QT4_HUMAN	Complement C1q tumor necrosis factor-related protein 4 (C1q/TNF-related protein 4)	C1QTNF4 CTRP4	Homo sapiens (Human)	329	FUNCTION: May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent (PubMed:21658842, PubMed:27086950). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 hours post-injection (By similarity). {ECO:0000250|UniProtKB:Q8R066, ECO:0000269|PubMed:21658842, ECO:0000269|PubMed:27086950}.		positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of tumor necrosis factor production [GO:0032760]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of tumor necrosis factor production [GO:0032760]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21658842}.
Q9BXJ4	reviewed	C1QT3_HUMAN	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	C1QTNF3 CTRP3 UNQ753/PRO1484	Homo sapiens (Human)	246			fat cell differentiation [GO:0045444]; intracellular triglyceride homeostasis [GO:0035356]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]	collagen trimer [GO:0005581]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]	identical protein binding [GO:0042802]	collagen trimer [GO:0005581]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; identical protein binding [GO:0042802]; fat cell differentiation [GO:0045444]; intracellular triglyceride homeostasis [GO:0035356]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BXJ5	reviewed	C1QT2_HUMAN	Complement C1q tumor necrosis factor-related protein 2	C1QTNF2 CTRP2 UNQ6349/PRO21054	Homo sapiens (Human)	285	FUNCTION: Involved in the regulation of lipid metabolism in adipose tissue and liver. {ECO:0000250|UniProtKB:Q9D8U4}.		regulation of lipid metabolic process [GO:0019216]	collagen trimer [GO:0005581]; extracellular region [GO:0005576]		collagen trimer [GO:0005581]; extracellular region [GO:0005576]; regulation of lipid metabolic process [GO:0019216]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BXJ7	reviewed	AMNLS_HUMAN	Protein amnionless [Cleaved into: Soluble protein amnionless]	AMN UNQ513/PRO1028	Homo sapiens (Human)	453	FUNCTION: Membrane-bound component of the endocytic receptor formed by AMN and CUBN (PubMed:14576052, PubMed:30523278, PubMed:29402915). Required for normal CUBN glycosylation and trafficking to the cell surface (PubMed:14576052, PubMed:29402915). The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052, PubMed:26040326). Required for normal CUBN-mediated protein transport in the kidney (Probable). {ECO:0000269|PubMed:12590260, ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:26040326, ECO:0000269|PubMed:29402915, ECO:0000269|PubMed:30523278, ECO:0000305|PubMed:22631584, ECO:0000305|PubMed:26040326}.	MISCELLANEOUS: The role of Amn in embryonic development seems to be species specific. In mice, null mutations lead to embryonic lethality. Human mutations give rise to much milder symptoms. {ECO:0000305}.	cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; Golgi to plasma membrane protein transport [GO:0043001]; protein localization [GO:0008104]; receptor-mediated endocytosis [GO:0006898]; renal protein absorption [GO:0097017]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cargo receptor activity [GO:0038024]; signaling receptor binding [GO:0005102]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cargo receptor activity [GO:0038024]; signaling receptor binding [GO:0005102]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; Golgi to plasma membrane protein transport [GO:0043001]; protein localization [GO:0008104]; receptor-mediated endocytosis [GO:0006898]; renal protein absorption [GO:0097017]	SUBCELLULAR LOCATION: [Isoform 1]: Apical cell membrane {ECO:0000269|PubMed:14576052}; Single-pass type I membrane protein {ECO:0000305|PubMed:30523278}. Cell membrane {ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:29402915, ECO:0000269|PubMed:30523278}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000305|PubMed:14576052}. Membrane, coated pit {ECO:0000305|PubMed:14576052}.; SUBCELLULAR LOCATION: [Soluble protein amnionless]: Secreted {ECO:0000269|PubMed:14576052}.
Q9BXJ8	reviewed	TACAN_HUMAN	Ion channel TACAN (Transmembrane protein 120A) (Transmembrane protein induced by tumor necrosis factor alpha)	TMEM120A TACAN TMPIT	Homo sapiens (Human)	343	FUNCTION: Ion channel involved in sensing mechanical pain. Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli (By similarity). May also be required for efficient adipogenesis (PubMed:26024229). {ECO:0000250|UniProtKB:Q8C1E7, ECO:0000269|PubMed:26024229}.	MISCELLANEOUS: TACAN means movement in Farsi. {ECO:0000303|PubMed:32084332}.	detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; fat cell differentiation [GO:0045444]; monoatomic ion transmembrane transport [GO:0034220]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]	membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]	monoatomic ion channel activity [GO:0005216]	membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]; monoatomic ion channel activity [GO:0005216]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; fat cell differentiation [GO:0045444]; monoatomic ion transmembrane transport [GO:0034220]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8C1E7}; Multi-pass membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q8C1E7}; Multi-pass membrane protein {ECO:0000255}.
Q9BXJ9	reviewed	NAA15_HUMAN	N-alpha-acetyltransferase 15, NatA auxiliary subunit (Gastric cancer antigen Ga19) (N-terminal acetyltransferase) (NMDA receptor-regulated protein 1) (Protein tubedown-1) (Tbdn100)	NAA15 GA19 NARG1 NATH TBDN100	Homo sapiens (Human)	866	FUNCTION: Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062). The NAT activity may be important for vascular, hematopoietic and neuronal growth and development (PubMed:15496142). Required to control retinal neovascularization in adult ocular endothelial cells (PubMed:11687548). In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (PubMed:12145306). {ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}.		angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; N-terminal protein amino acid acetylation [GO:0006474]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA-templated transcription [GO:0045893]; protein stabilization [GO:0050821]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; NatA complex [GO:0031415]; nuclear body [GO:0016604]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; NatA complex [GO:0031415]; nuclear body [GO:0016604]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; N-terminal protein amino acid acetylation [GO:0006474]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA-templated transcription [GO:0045893]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.
Q9BXK5	reviewed	B2L13_HUMAN	Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1)	BCL2L13 MIL1 CD003	Homo sapiens (Human)	485	FUNCTION: May promote the activation of caspase-3 and apoptosis.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981]	membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]	membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000305}.
Q9BXL6	reviewed	CAR14_HUMAN	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2)	CARD14 CARMA2	Homo sapiens (Human)	1004	FUNCTION: Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}.		activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	CARD domain binding [GO:0050700]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; CARD domain binding [GO:0050700]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:21302310}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:21302310}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:21302310}.
Q9BXL7	reviewed	CAR11_HUMAN	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1)	CARD11 CARMA1	Homo sapiens (Human)	1154	FUNCTION: Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}.		B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; canonical NF-kappaB signal transduction [GO:0007249]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; homeostasis of number of cells [GO:0048872]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein homooligomerization [GO:0051260]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of T cell differentiation [GO:0045580]; T cell costimulation [GO:0031295]; thymic T cell selection [GO:0045061]; TORC1 signaling [GO:0038202]	CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	CARD domain binding [GO:0050700]; guanylate kinase activity [GO:0004385]; protein self-association [GO:0043621]	CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; CARD domain binding [GO:0050700]; guanylate kinase activity [GO:0004385]; protein self-association [GO:0043621]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; canonical NF-kappaB signal transduction [GO:0007249]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; homeostasis of number of cells [GO:0048872]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein homooligomerization [GO:0051260]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of T cell differentiation [GO:0045580]; T cell costimulation [GO:0031295]; thymic T cell selection [GO:0045061]; TORC1 signaling [GO:0038202]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17287217}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:17287217}.
Q9BXL8	reviewed	CDCA4_HUMAN	Cell division cycle-associated protein 4 (Hematopoietic progenitor protein)	CDCA4 HEPP	Homo sapiens (Human)	241	FUNCTION: May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:16984923}.			cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16984923}.
Q9BXM0	reviewed	PRAX_HUMAN	Periaxin	PRX KIAA1620	Homo sapiens (Human)	1461	FUNCTION: Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology. {ECO:0000250|UniProtKB:O55103}.		axon ensheathment [GO:0008366]; peripheral nervous system myelin maintenance [GO:0032287]; regulation of RNA splicing [GO:0043484]	anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; axon ensheathment [GO:0008366]; peripheral nervous system myelin maintenance [GO:0032287]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:O55103}; Peripheral membrane protein {ECO:0000250|UniProtKB:O55103}; Cytoplasmic side {ECO:0000250|UniProtKB:O55103}. Nucleus {ECO:0000269|PubMed:24633211}. Cytoplasm {ECO:0000269|PubMed:24633211}. Note=Detected in the Schwann cell nucleus prior to the onset of myelination. Detected in Schwann cells at periaxonal myelin membranes. Associated with the cell membrane during myelination. {ECO:0000250|UniProtKB:O55103}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:O55103}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O55103}. Cell junction {ECO:0000250|UniProtKB:O55103}. Note=Colocalizes with ACTB at tricellular junctions between eye lens fiber cells. {ECO:0000250|UniProtKB:O55103}.
Q9BXM7	reviewed	PINK1_HUMAN	Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)	PINK1	Homo sapiens (Human)	581	FUNCTION: Serine/threonine-protein kinase which protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins such as PRKN and DNM1L, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:14607334, PubMed:18957282, PubMed:18443288, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:22396657, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24898855, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291, PubMed:32484300, PubMed:20547144). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:18443288, PubMed:23620051, PubMed:24898855, PubMed:20798600, PubMed:20404107, PubMed:19966284, PubMed:32484300, PubMed:22396657, PubMed:32047033, PubMed:15087508). Mediates the translocation and activation of PRKN at the outer membrane (OMM) of dysfunctional/depolarized mitochondria (PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25474007, PubMed:25527291). At the OMM of damaged mitochondria, phosphorylates pre-existing polyubiquitin chains at 'Ser-65', the PINK1-phosphorylated polyubiquitin then recruits PRKN from the cytosol to the OMM where PRKN is fully activated by phosphorylation at 'Ser-65' by PINK1 (PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25474007, PubMed:25527291). In damaged mitochondria, mediates the decision between mitophagy or preventing apoptosis by promoting PRKN-dependent poly- or monoubiquitination of VDAC1; polyubiquitination of VDAC1 by PRKN promotes mitophagy, while monoubiquitination of VDAC1 by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, functions with PRKN to promote clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:14607334, PubMed:20798600, PubMed:20404107, PubMed:19966284, PubMed:23933751, PubMed:15087508). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by phosphorylating and thus promoting the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:18443288, PubMed:23620051, PubMed:24898855). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:18443288, PubMed:23620051). Also promotes mitochondrial fission independently of PRKN and ATG7-mediated mitophagy, via the phosphorylation and activation of DNM1L (PubMed:18443288, PubMed:32484300). Regulates motility of damaged mitochondria by promoting the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). Phosphorylates LETM1, positively regulating its mitochondrial calcium transport activity (PubMed:29123128). {ECO:0000250|UniProtKB:Q99MQ3, ECO:0000269|PubMed:14607334, ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:18443288, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20404107, ECO:0000269|PubMed:20547144, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:24898855, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:29123128, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:32484300}.		activation of protein kinase B activity [GO:0032148]; autophagy of mitochondrion [GO:0000422]; cellular response to hydrogen sulfide [GO:1904881]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; dopamine secretion [GO:0014046]; establishment of protein localization to mitochondrion [GO:0072655]; hemopoiesis [GO:0030097]; intracellular signal transduction [GO:0035556]; maintenance of protein location in mitochondrion [GO:0072656]; mitochondrion organization [GO:0007005]; mitochondrion to lysosome transport [GO:0099074]; mitophagy [GO:0000423]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of JNK cascade [GO:0046329]; negative regulation of macroautophagy [GO:0016242]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitophagy [GO:1901525]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cristae formation [GO:1903852]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of free ubiquitin chain polymerization [GO:1904544]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of peptidase activity [GO:0010952]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of translation [GO:0045727]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of oxidative phosphorylation [GO:0002082]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of protein-containing complex assembly [GO:0043254]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synaptic vesicle transport [GO:1902803]; respiratory electron transport chain [GO:0022904]; response to ischemia [GO:0002931]; response to oxidative stress [GO:0006979]; TORC2 signaling [GO:0038203]; ubiquitin-dependent protein catabolic process [GO:0006511]	astrocyte projection [GO:0097449]; axon [GO:0030424]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; Lewy body [GO:0097413]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; C3HC4-type RING finger domain binding [GO:0055131]; calcium-dependent protein kinase activity [GO:0010857]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; peptidase activator activity [GO:0016504]; protease binding [GO:0002020]; protein kinase activity [GO:0004672]; protein kinase B binding [GO:0043422]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; TORC2 complex binding [GO:1904841]; ubiquitin protein ligase binding [GO:0031625]	astrocyte projection [GO:0097449]; axon [GO:0030424]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; Lewy body [GO:0097413]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; C3HC4-type RING finger domain binding [GO:0055131]; calcium-dependent protein kinase activity [GO:0010857]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; peptidase activator activity [GO:0016504]; protease binding [GO:0002020]; protein kinase activity [GO:0004672]; protein kinase B binding [GO:0043422]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; TORC2 complex binding [GO:1904841]; ubiquitin protein ligase binding [GO:0031625]; activation of protein kinase B activity [GO:0032148]; autophagy of mitochondrion [GO:0000422]; cellular response to hydrogen sulfide [GO:1904881]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; dopamine secretion [GO:0014046]; establishment of protein localization to mitochondrion [GO:0072655]; hemopoiesis [GO:0030097]; intracellular signal transduction [GO:0035556]; maintenance of protein location in mitochondrion [GO:0072656]; mitochondrion organization [GO:0007005]; mitochondrion to lysosome transport [GO:0099074]; mitophagy [GO:0000423]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of JNK cascade [GO:0046329]; negative regulation of macroautophagy [GO:0016242]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitophagy [GO:1901525]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cristae formation [GO:1903852]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of free ubiquitin chain polymerization [GO:1904544]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of peptidase activity [GO:0010952]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of translation [GO:0045727]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of oxidative phosphorylation [GO:0002082]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of protein-containing complex assembly [GO:0043254]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synaptic vesicle transport [GO:1902803]; respiratory electron transport chain [GO:0022904]; response to ischemia [GO:0002931]; response to oxidative stress [GO:0006979]; TORC2 signaling [GO:0038203]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:16672980, ECO:0000269|PubMed:18687899, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:31536960}; Single-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q99MQ3}; Single-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:22354088}. Note=Localizes mostly in mitochondrion and the two smaller proteolytic processed fragments localize mainly in cytosol (PubMed:19229105). When mitochondria lose mitochondrial membrane potential following damage, PINK1 import is arrested, which induces its accumulation in the outer mitochondrial membrane, where it acquires kinase activity (PubMed:18957282). {ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19229105}.
Q9BXN1	reviewed	ASPN_HUMAN	Asporin (Periodontal ligament-associated protein 1) (PLAP-1)	ASPN PLAP1 SLRR1C UNQ215/PRO241	Homo sapiens (Human)	380	FUNCTION: Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity. {ECO:0000250, ECO:0000269|PubMed:17827158, ECO:0000269|PubMed:19589127}.		bone mineralization [GO:0030282]; negative regulation of tooth mineralization [GO:0070171]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; response to fluoride [GO:1902617]	cell projection [GO:0042995]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]	cell projection [GO:0042995]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; bone mineralization [GO:0030282]; negative regulation of tooth mineralization [GO:0070171]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; response to fluoride [GO:1902617]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17827158}.
Q9BXN2	reviewed	CLC7A_HUMAN	C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)	CLEC7A BGR CLECSF12 DECTIN1 UNQ539/PRO1082	Homo sapiens (Human)	247	FUNCTION: Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia (PubMed:17230442). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). {ECO:0000250|UniProtKB:Q6QLQ4, ECO:0000269|PubMed:11567029, ECO:0000269|PubMed:12423684, ECO:0000269|PubMed:17230442}.	MISCELLANEOUS: [Isoform 2]: Predominant isoform. {ECO:0000305}.	antifungal innate immune response [GO:0061760]; carbohydrate mediated signaling [GO:0009756]; cell activation [GO:0001775]; cell recognition [GO:0008037]; cellular response to molecule of fungal origin [GO:0071226]; defense response to protozoan [GO:0042832]; detection of fungus [GO:0016046]; detection of molecule of fungal origin [GO:0032491]; detection of yeast [GO:0001879]; inflammatory response [GO:0006954]; phagocytosis, recognition [GO:0006910]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell maturation [GO:1903431]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of killing of cells of another organism [GO:0051712]; positive regulation of lymphocyte activation [GO:0051251]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of respiratory burst [GO:0060267]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of wound healing [GO:0090303]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; response to yeast [GO:0001878]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell activation [GO:0042110]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	(1->3)-beta-D-glucan binding [GO:0001872]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; MHC protein binding [GO:0042287]; pattern recognition receptor activity [GO:0038187]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; (1->3)-beta-D-glucan binding [GO:0001872]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; MHC protein binding [GO:0042287]; pattern recognition receptor activity [GO:0038187]; antifungal innate immune response [GO:0061760]; carbohydrate mediated signaling [GO:0009756]; cell activation [GO:0001775]; cell recognition [GO:0008037]; cellular response to molecule of fungal origin [GO:0071226]; defense response to protozoan [GO:0042832]; detection of fungus [GO:0016046]; detection of molecule of fungal origin [GO:0032491]; detection of yeast [GO:0001879]; inflammatory response [GO:0006954]; phagocytosis, recognition [GO:0006910]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell maturation [GO:1903431]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of killing of cells of another organism [GO:0051712]; positive regulation of lymphocyte activation [GO:0051251]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of respiratory burst [GO:0060267]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of wound healing [GO:0090303]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; response to yeast [GO:0001878]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:16870151, ECO:0000269|PubMed:17230442}; Single-pass type II membrane protein {ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:16870151, ECO:0000269|PubMed:17230442}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm {ECO:0000305}.
Q9BXP2	reviewed	S12A9_HUMAN	Solute carrier family 12 member 9 (Cation-chloride cotransporter 6) (hCCC6) (Cation-chloride cotransporter-interacting protein 1) (CCC-interacting protein 1) (hCIP1) (Potassium-chloride transporter 9) (WO3.3)	SLC12A9 CCC6 CIP1	Homo sapiens (Human)	914	FUNCTION: May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function. {ECO:0000269|PubMed:10871601}.		cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; potassium ion homeostasis [GO:0055075]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	chloride:monoatomic cation symporter activity [GO:0015377]; potassium:chloride symporter activity [GO:0015379]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; chloride:monoatomic cation symporter activity [GO:0015377]; potassium:chloride symporter activity [GO:0015379]; cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; potassium ion homeostasis [GO:0055075]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10871601}; Multi-pass membrane protein {ECO:0000269|PubMed:10871601}.
Q9BXP5	reviewed	SRRT_HUMAN	Serrate RNA effector molecule homolog (Arsenite-resistance protein 2)	SRRT ARS2 ASR2	Homo sapiens (Human)	876	FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}.		mRNA processing [GO:0006397]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of neurogenesis [GO:0050769]; primary miRNA processing [GO:0031053]; regulation of DNA-templated transcription [GO:0006355]; response to arsenic-containing substance [GO:0046685]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]	DNA binding [GO:0003677]; mRNA cap binding complex binding [GO:0140262]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; DNA binding [GO:0003677]; mRNA cap binding complex binding [GO:0140262]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of neurogenesis [GO:0050769]; primary miRNA processing [GO:0031053]; regulation of DNA-templated transcription [GO:0006355]; response to arsenic-containing substance [GO:0046685]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity). {ECO:0000250}.
Q9BXP8	reviewed	PAPP2_HUMAN	Pappalysin-2 (EC 3.4.24.-) (Pregnancy-associated plasma protein A2) (PAPP-A2) (Pregnancy-associated plasma protein E1) (PAPP-E)	PAPPA2 PLAC3	Homo sapiens (Human)	1791	FUNCTION: Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. {ECO:0000269|PubMed:11264294, ECO:0000269|PubMed:26902202}.		bone morphogenesis [GO:0060349]; cell surface receptor signaling pathway [GO:0007166]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]; regulation of cell growth [GO:0001558]; response to salt stress [GO:0009651]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; bone morphogenesis [GO:0060349]; cell surface receptor signaling pathway [GO:0007166]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]; regulation of cell growth [GO:0001558]; response to salt stress [GO:0009651]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q9BXR0	reviewed	TGT_HUMAN	Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.64) (Guanine insertion enzyme) (tRNA-guanine transglycosylase)	QTRT1 TGT TGUT	Homo sapiens (Human)	403	FUNCTION: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:11255023, PubMed:20354154). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity). {ECO:0000250|UniProtKB:P28720, ECO:0000255|HAMAP-Rule:MF_03218, ECO:0000269|PubMed:11255023, ECO:0000269|PubMed:20354154}.		tRNA modification [GO:0006400]; tRNA-guanine transglycosylation [GO:0101030]	mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transferase complex [GO:1990234]	metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479]	mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transferase complex [GO:1990234]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479]; tRNA modification [GO:0006400]; tRNA-guanine transglycosylation [GO:0101030]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03218}. Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03218}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03218}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03218}. Note=Weakly associates with mitochondria, possibly via QTRT2. {ECO:0000255|HAMAP-Rule:MF_03218}.
Q9BXR3	reviewed	POK6_HUMAN	Endogenous retrovirus group K member 6 Pol protein (HERV-K(C7) Pol protein) (HERV-K(HML-2.HOM) Pol protein) (HERV-K108 Pol protein) (HERV-K_7p22.1 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]	ERVK-6 ERVK6	Homo sapiens (Human)	956	FUNCTION: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein precursors. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; MISCELLANEOUS: Exact N-terminus of this protein has not been formally described.; MISCELLANEOUS: Two human-specific proviruses are inserted as tandem repeats with a shared LTR in most individuals tested. The telomeric copy is referred here as 'provirus 41574'. The centromeric copy is referred here as 'provirus 41575'.	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]		DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]	DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]	
Q9BXR5	reviewed	TLR10_HUMAN	Toll-like receptor 10 (CD antigen CD290)	TLR10 UNQ315/PRO358	Homo sapiens (Human)	811	FUNCTION: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). {ECO:0000250}.		cellular response to bacterial lipopeptide [GO:0071221]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224]	membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]; cellular response to bacterial lipopeptide [GO:0071221]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9BXR6	reviewed	FHR5_HUMAN	Complement factor H-related protein 5 (FHR-5)	CFHR5 CFHL5 FHR5	Homo sapiens (Human)	569	FUNCTION: Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. {ECO:0000269|PubMed:23487775}.		complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; cytolysis by host of symbiont cells [GO:0051838]; negative regulation of protein binding [GO:0032091]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]	complement component C3b binding [GO:0001851]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]; complement component C3b binding [GO:0001851]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; cytolysis by host of symbiont cells [GO:0051838]; negative regulation of protein binding [GO:0032091]	SUBCELLULAR LOCATION: Secreted.
Q9BXS0	reviewed	COPA1_HUMAN	Collagen alpha-1(XXV) chain (Alzheimer disease amyloid-associated protein) (AMY) (CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component (CLAC)]	COL25A1	Homo sapiens (Human)	654	FUNCTION: Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. {ECO:0000269|PubMed:15522881, ECO:0000269|PubMed:15615705, ECO:0000269|PubMed:15853808, ECO:0000269|PubMed:16300410}.			collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]	amyloid-beta binding [GO:0001540]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; amyloid-beta binding [GO:0001540]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=After proteolytic cleavage, CLAC is secreted.
Q9BXS1	reviewed	IDI2_HUMAN	Isopentenyl-diphosphate delta-isomerase 2 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 2) (IPP isomerase 2) (IPPI2)	IDI2	Homo sapiens (Human)	227	FUNCTION: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). {ECO:0000269|PubMed:17202134}.		cholesterol biosynthetic process [GO:0006695]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isopentenyl diphosphate biosynthetic process [GO:0009240]; isopentenyl diphosphate metabolic process [GO:0046490]; isoprenoid biosynthetic process [GO:0008299]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisome [GO:0005777]	isopentenyl-diphosphate delta-isomerase activity [GO:0004452]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisome [GO:0005777]; isopentenyl-diphosphate delta-isomerase activity [GO:0004452]; metal ion binding [GO:0046872]; cholesterol biosynthetic process [GO:0006695]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isopentenyl diphosphate biosynthetic process [GO:0009240]; isopentenyl diphosphate metabolic process [GO:0046490]; isoprenoid biosynthetic process [GO:0008299]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:17202134}.
Q9BXS4	reviewed	TMM59_HUMAN	Transmembrane protein 59 (Liver membrane-bound protein)	TMEM59 C1orf8 HSPC001 UNQ169/PRO195	Homo sapiens (Human)	323	FUNCTION: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278). {ECO:0000269|PubMed:20427278, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}.		autophagy [GO:0006914]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of autophagy [GO:0010508]; protein glycosylation [GO:0006486]	extracellular exosome [GO:0070062]; Golgi cis cisterna [GO:0000137]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	endopeptidase activity [GO:0004175]	extracellular exosome [GO:0070062]; Golgi cis cisterna [GO:0000137]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; autophagy [GO:0006914]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of autophagy [GO:0010508]; protein glycosylation [GO:0006486]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:23376921}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:20427278}; Single-pass type I membrane protein {ECO:0000255}. Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded. {ECO:0000269|PubMed:23376921}.
Q9BXS5	reviewed	AP1M1_HUMAN	AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin)	AP1M1 CLTNM	Homo sapiens (Human)	423	FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.		endosome to melanosome transport [GO:0035646]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; platelet dense granule organization [GO:0060155]; vesicle-mediated transport [GO:0016192]	AP-1 adaptor complex [GO:0030121]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; trans-Golgi network membrane [GO:0032588]	clathrin adaptor activity [GO:0035615]	AP-1 adaptor complex [GO:0030121]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; trans-Golgi network membrane [GO:0032588]; clathrin adaptor activity [GO:0035615]; endosome to melanosome transport [GO:0035646]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; platelet dense granule organization [GO:0060155]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Q9BXS6	reviewed	NUSAP_HUMAN	Nucleolar and spindle-associated protein 1 (NuSAP)	NUSAP1 ANKT BM-037 PRO0310	Homo sapiens (Human)	441	FUNCTION: Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}.		establishment of mitotic spindle localization [GO:0040001]; mitotic chromosome condensation [GO:0007076]; mitotic cytokinesis [GO:0000281]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of mitotic nuclear division [GO:0045840]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]	DNA binding [GO:0003677]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; DNA binding [GO:0003677]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]; establishment of mitotic spindle localization [GO:0040001]; mitotic chromosome condensation [GO:0007076]; mitotic cytokinesis [GO:0000281]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of mitotic nuclear division [GO:0045840]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome {ECO:0000250}. Note=Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase (By similarity). Localizes to the mitotic spindle during anaphase and telophase then disappears from around the chromosomes during cytokinesis (By similarity). Localizes to multiple distinct regions of chromosomes throughout mitosis. {ECO:0000250, ECO:0000269|PubMed:17276916, ECO:0000269|PubMed:17618083}.
Q9BXS9	reviewed	S26A6_HUMAN	Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1)	SLC26A6	Homo sapiens (Human)	759	FUNCTION: Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH. {ECO:0000250|UniProtKB:Q8CIW6, ECO:0000269|PubMed:20501439, ECO:0000269|PubMed:27681177}.; FUNCTION: [Isoform 4]: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. {ECO:0000269|PubMed:15990874}.		angiotensin-activated signaling pathway [GO:0038166]; bicarbonate transport [GO:0015701]; cellular response to cAMP [GO:0071320]; cellular response to fructose stimulus [GO:0071332]; cellular response to type II interferon [GO:0071346]; chloride transport [GO:0006821]; epithelial fluid transport [GO:0042045]; establishment of localization in cell [GO:0051649]; estrous cycle [GO:0044849]; formate transport [GO:0015724]; intestinal absorption [GO:0050892]; intracellular pH elevation [GO:0051454]; mannitol transmembrane transport [GO:0015797]; monoatomic ion transport [GO:0006811]; oxalate transport [GO:0019532]; oxalic acid secretion [GO:0046724]; positive regulation of dipeptide transmembrane transport [GO:2001150]; protein kinase C signaling [GO:0070528]; regulation of intracellular pH [GO:0051453]; sperm capacitation [GO:0048240]; sulfate transport [GO:0008272]; transepithelial chloride transport [GO:0030321]; transepithelial transport [GO:0070633]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]; vesicle [GO:0031982]; vesicle membrane [GO:0012506]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; efflux transmembrane transporter activity [GO:0015562]; formate transmembrane transporter activity [GO:0015499]; identical protein binding [GO:0042802]; oxalate transmembrane transporter activity [GO:0019531]; PDZ domain binding [GO:0030165]; secondary active sulfate transmembrane transporter activity [GO:0008271]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:bicarbonate antiporter activity [GO:0015383]; transferase activity [GO:0016740]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]; vesicle [GO:0031982]; vesicle membrane [GO:0012506]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; efflux transmembrane transporter activity [GO:0015562]; formate transmembrane transporter activity [GO:0015499]; identical protein binding [GO:0042802]; oxalate transmembrane transporter activity [GO:0019531]; PDZ domain binding [GO:0030165]; secondary active sulfate transmembrane transporter activity [GO:0008271]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:bicarbonate antiporter activity [GO:0015383]; transferase activity [GO:0016740]; angiotensin-activated signaling pathway [GO:0038166]; bicarbonate transport [GO:0015701]; cellular response to cAMP [GO:0071320]; cellular response to fructose stimulus [GO:0071332]; cellular response to type II interferon [GO:0071346]; chloride transport [GO:0006821]; epithelial fluid transport [GO:0042045]; establishment of localization in cell [GO:0051649]; estrous cycle [GO:0044849]; formate transport [GO:0015724]; intestinal absorption [GO:0050892]; intracellular pH elevation [GO:0051454]; mannitol transmembrane transport [GO:0015797]; monoatomic ion transport [GO:0006811]; oxalate transport [GO:0019532]; oxalic acid secretion [GO:0046724]; positive regulation of dipeptide transmembrane transport [GO:2001150]; protein kinase C signaling [GO:0070528]; regulation of intracellular pH [GO:0051453]; sperm capacitation [GO:0048240]; sulfate transport [GO:0008272]; transepithelial chloride transport [GO:0030321]; transepithelial transport [GO:0070633]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11247665, ECO:0000269|PubMed:27681177}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:20501439}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8CIW6}; Multi-pass membrane protein {ECO:0000255}. Microsome {ECO:0000250|UniProtKB:Q8CIW6}. Note=Localized in sperm membranes. Colocalizes with CFTR at the midpiece of sperm tail. Localizes to the apical membrane brush border of epithelial cells in the proximal tubules of kidney, of enterocytes of the small intestine and of gastric parietal cells in the stomach. {ECO:0000250|UniProtKB:Q8CIW6}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:12444019, ECO:0000269|PubMed:15990874}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:11087667}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:11087667}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the apical and basolateral surfaces of tubular wall cells in kidney and in the brush border of pancreatic duct cells (PubMed:11087667). Colocalized with CA2 at the surface of the cell membrane in order to form a bicarbonate transport metabolon; colocalization is reduced in phorbol myristate acetate (PMA)-induced cells (PubMed:15990874). May be translocated from the cytosolic surface of the cell membrane to the intracellular space by PKC in phorbol myristate acetate (PMA)-induced cells (PubMed:15990874). {ECO:0000269|PubMed:11087667, ECO:0000269|PubMed:15990874}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane {ECO:0000269|PubMed:12444019}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane {ECO:0000269|PubMed:12444019}; Multi-pass membrane protein {ECO:0000255}.
Q9BXT4	reviewed	TDRD1_HUMAN	Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1)	TDRD1	Homo sapiens (Human)	1180	FUNCTION: Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity). {ECO:0000250}.		germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186]; pi-body [GO:0071546]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]	metal ion binding [GO:0046872]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186]; pi-body [GO:0071546]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]; metal ion binding [GO:0046872]; germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity). {ECO:0000250}.
Q9BXT5	reviewed	TEX15_HUMAN	Testis-expressed protein 15 (Cancer/testis antigen 42) (CT42)	TEX15	Homo sapiens (Human)	2789	FUNCTION: Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair (By similarity). Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (By similarity). PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci (By similarity). Not required for piRNA biosynthesis (By similarity). {ECO:0000250|UniProtKB:F8VPN2}.		cell differentiation [GO:0030154]; DNA methylation-dependent heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; male meiotic nuclear division [GO:0007140]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; cell differentiation [GO:0030154]; DNA methylation-dependent heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; male meiotic nuclear division [GO:0007140]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:F8VPN2}. Nucleus {ECO:0000250|UniProtKB:F8VPN2}.
Q9BXT6	reviewed	M10L1_HUMAN	RNA helicase Mov10l1 (EC 3.6.4.13) (Moloney leukemia virus 10-like protein 1) (MOV10-like protein 1)	MOV10L1	Homo sapiens (Human)	1211	FUNCTION: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. {ECO:0000250|UniProtKB:Q99MV5}.		germ cell development [GO:0007281]; male meiosis I [GO:0007141]; piRNA processing [GO:0034587]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; P granule [GO:0043186]; pi-body [GO:0071546]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytosol [GO:0005829]; P granule [GO:0043186]; pi-body [GO:0071546]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; germ cell development [GO:0007281]; male meiosis I [GO:0007141]; piRNA processing [GO:0034587]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99MV5}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q99MV5}.
Q9BXT8	reviewed	RNF17_HUMAN	RING finger protein 17 (Tudor domain-containing protein 4)	RNF17 TDRD4	Homo sapiens (Human)	1623	FUNCTION: Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). {ECO:0000250}.		spermatid development [GO:0007286]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly found in the cytoplasm. Component of a nuage in male germ cells (an electron-dense spherical cytoplasmic body present in late pachytene and diplotene spermatocytes and in elonging spermatids) (By similarity). {ECO:0000250}.
Q9BXU0	reviewed	TEX12_HUMAN	Testis-expressed protein 12	TEX12	Homo sapiens (Human)	123	FUNCTION: Component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (By similarity). Requires SYCP1 in order to be incorporated into the central element (By similarity). {ECO:0000250|UniProtKB:Q9CR81}.		meiotic DNA repair synthesis [GO:0000711]; synaptonemal complex assembly [GO:0007130]	central element [GO:0000801]; chromosome [GO:0005694]		central element [GO:0000801]; chromosome [GO:0005694]; meiotic DNA repair synthesis [GO:0000711]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9CR81}. Note=In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. {ECO:0000250|UniProtKB:Q9CR81}.
Q9BXU1	reviewed	STK31_HUMAN	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine-protein kinase NYD-SPK) (Sugen kinase 396) (SgK396)	STK31 SGK396	Homo sapiens (Human)	1019			phosphorylation [GO:0016310]	acrosomal vesicle [GO:0001669]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	acrosomal vesicle [GO:0001669]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	
Q9BXU7	reviewed	UBP26_HUMAN	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.4.19.12) (Deubiquitinating enzyme 26) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26)	USP26	Homo sapiens (Human)	913	FUNCTION: Deubiquitinase regulating several biological processes through the deubiquitination of components of these processes (PubMed:28839133, PubMed:20501646). Involved in somatic cell reprogramming through the 'Lys-48'-linked deubiquitination and stabilization of CBX4 and CBX6, two components of the polycomb-repressive complex 1 (PRC1) (PubMed:28839133). Also deubiquitinates and probably stabilizes the androgen receptor (AR), regulating the androgen receptor signaling pathway (PubMed:20501646). May play a role in spermatogenesis (PubMed:34202084). {ECO:0000269|PubMed:20501646, ECO:0000269|PubMed:28839133, ECO:0000269|PubMed:34202084}.		G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; proteolysis [GO:0006508]; regulation of androgen receptor signaling pathway [GO:0060765]; spermatogenesis [GO:0007283]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; proteolysis [GO:0006508]; regulation of androgen receptor signaling pathway [GO:0060765]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20501646}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:34202084}.
Q9BXU9	reviewed	CABP8_HUMAN	Calcium-binding protein 8 (CaBP8) (Calneuron I) (Calneuron-1)	CALN1 CABP8	Homo sapiens (Human)	261	FUNCTION: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning. {ECO:0000250|UniProtKB:Q06BI3}.			perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	calcium ion binding [GO:0005509]	perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000305|PubMed:19338761}; Single-pass type IV membrane protein {ECO:0000305|PubMed:19338761}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19338761}. Cell membrane {ECO:0000305|PubMed:19338761}; Single-pass type IV membrane protein {ECO:0000305|PubMed:19338761}.
Q9BXV9	reviewed	GON7_HUMAN	EKC/KEOPS complex subunit GON7	GON7 C14orf142	Homo sapiens (Human)	100	FUNCTION: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:27903914, PubMed:31481669). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:27903914, PubMed:31481669). GON7 plays a supporting role to the catalytic subunit OSGEP in the complex (PubMed:27903914, PubMed:31481669). {ECO:0000269|PubMed:31481669, ECO:0000305|PubMed:27903914}.		tRNA threonylcarbamoyladenosine modification [GO:0002949]	cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA threonylcarbamoyladenosine modification [GO:0002949]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27903914}.
Q9BXW4	reviewed	MLP3C_HUMAN	Microtubule-associated proteins 1A/1B light chain 3C (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (MAP1A/MAP1B light chain 3 C) (MAP1A/MAP1B LC3 C) (Microtubule-associated protein 1 light chain 3 gamma)	MAP1LC3C	Homo sapiens (Human)	147	FUNCTION: Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2 (PubMed:23022382). Recruits all ATG8 family members to infecting bacteria such as S.typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643). {ECO:0000269|PubMed:23022382, ECO:0000269|PubMed:28404643}.		aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; macroautophagy [GO:0016236]; protein exit from endoplasmic reticulum [GO:0032527]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; microtubule [GO:0005874]; organelle membrane [GO:0031090]	phosphatidylethanolamine binding [GO:0008429]; ubiquitin protein ligase binding [GO:0031625]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; microtubule [GO:0005874]; organelle membrane [GO:0031090]; phosphatidylethanolamine binding [GO:0008429]; ubiquitin protein ligase binding [GO:0031625]; aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; macroautophagy [GO:0016236]; protein exit from endoplasmic reticulum [GO:0032527]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:12740394, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:31709703}; Lipid-anchor {ECO:0000269|PubMed:12740394}. Endomembrane system {ECO:0000269|PubMed:12740394}; Lipid-anchor {ECO:0000269|PubMed:12740394}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12740394}. Note=LC3-II binds to the autophagic membranes. {ECO:0000269|PubMed:12740394}.
Q9BXW6	reviewed	OSBL1_HUMAN	Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1)	OSBPL1A ORP1 OSBP8 OSBPL1 OSBPL1B	Homo sapiens (Human)	950	FUNCTION: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000250, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17428193}.		bile acid biosynthetic process [GO:0006699]; cholesterol metabolic process [GO:0008203]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; organelle membrane contact site [GO:0044232]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; phospholipid binding [GO:0005543]; sterol transporter activity [GO:0015248]	cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; organelle membrane contact site [GO:0044232]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; phospholipid binding [GO:0005543]; sterol transporter activity [GO:0015248]; bile acid biosynthetic process [GO:0006699]; cholesterol metabolic process [GO:0008203]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:29858488}. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes.
Q9BXW9	reviewed	FACD2_HUMAN	Fanconi anemia group D2 protein (Protein FACD2)	FANCD2 FACD	Homo sapiens (Human)	1451	FUNCTION: Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751}.	MISCELLANEOUS: [Isoform 1]: Less abundant than isoform 2, may be not functional. {ECO:0000305}.	brain morphogenesis [GO:0048854]; cellular response to oxidative stress [GO:0034599]; double-strand break repair involved in meiotic recombination [GO:1990918]; gamete generation [GO:0007276]; homologous chromosome pairing at meiosis [GO:0007129]; interstrand cross-link repair [GO:0036297]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; neuronal stem cell population maintenance [GO:0097150]; regulation of CD40 signaling pathway [GO:2000348]; regulation of inflammatory response [GO:0050727]; regulation of regulatory T cell differentiation [GO:0045589]; response to gamma radiation [GO:0010332]	chromatin [GO:0000785]; condensed chromosome [GO:0000793]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA polymerase binding [GO:0070182]	chromatin [GO:0000785]; condensed chromosome [GO:0000793]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA polymerase binding [GO:0070182]; brain morphogenesis [GO:0048854]; cellular response to oxidative stress [GO:0034599]; double-strand break repair involved in meiotic recombination [GO:1990918]; gamete generation [GO:0007276]; homologous chromosome pairing at meiosis [GO:0007129]; interstrand cross-link repair [GO:0036297]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; neuronal stem cell population maintenance [GO:0097150]; regulation of CD40 signaling pathway [GO:2000348]; regulation of inflammatory response [GO:0050727]; regulation of regulatory T cell differentiation [GO:0045589]; response to gamma radiation [GO:0010332]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12093742, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:19465922, ECO:0000269|PubMed:30335751}. Note=Concentrates in nuclear foci during S phase and upon genotoxic stress. At the onset of mitosis, excluded from chromosomes and diffuses into the cytoplasm, returning to the nucleus at the end of cell division. Observed in a few spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites and could be sites of replication fork stalling. The foci are frequently interlinked through BLM-associated ultra-fine DNA bridges. Following aphidicolin treatment, targets chromatid gaps and breaks.
Q9BXX0	reviewed	EMIL2_HUMAN	EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10)	EMILIN2	Homo sapiens (Human)	1053	FUNCTION: May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.		cell adhesion mediated by integrin [GO:0033627]; negative regulation of cell migration [GO:0030336]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood coagulation [GO:0030194]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of platelet aggregation [GO:1901731]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; EMILIN complex [GO:1990971]; extracellular region [GO:0005576]	extracellular matrix constituent conferring elasticity [GO:0030023]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; EMILIN complex [GO:1990971]; extracellular region [GO:0005576]; extracellular matrix constituent conferring elasticity [GO:0030023]; cell adhesion mediated by integrin [GO:0033627]; negative regulation of cell migration [GO:0030336]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood coagulation [GO:0030194]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of platelet aggregation [GO:1901731]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils.
Q9BXY4	reviewed	RSPO3_HUMAN	R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2)	RSPO3 PWTSR THSD2	Homo sapiens (Human)	272	FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) (PubMed:21727895, PubMed:21909076, PubMed:22615920). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720). {ECO:0000250|UniProtKB:Q2TJ95, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:29769720}.		blood vessel remodeling [GO:0001974]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; sprouting angiogenesis [GO:0002040]	extracellular region [GO:0005576]	frizzled binding [GO:0005109]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; frizzled binding [GO:0005109]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102]; blood vessel remodeling [GO:0001974]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; sprouting angiogenesis [GO:0002040]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q2TJ95}.
Q9BXY8	reviewed	BEX2_HUMAN	Protein BEX2 (Brain-expressed X-linked protein 2) (hBex2)	BEX2	Homo sapiens (Human)	128	FUNCTION: Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer (PubMed:19711341). Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA (PubMed:19711341). Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A (PubMed:19711341). Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (PubMed:19711341). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). {ECO:0000250|UniProtKB:Q9WTZ8, ECO:0000269|PubMed:19711341}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]; negative regulation of protein ubiquitination [GO:0031397]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	molecular function inhibitor activity [GO:0140678]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; molecular function inhibitor activity [GO:0140678]; signaling receptor binding [GO:0005102]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; negative regulation of protein ubiquitination [GO:0031397]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3MKQ1}. Nucleus {ECO:0000269|PubMed:16314316}.
Q9BY07	reviewed	S4A5_HUMAN	Electrogenic sodium bicarbonate cotransporter 4 (NBCe2) (Solute carrier family 4 member 5)	SLC4A5 NBC4	Homo sapiens (Human)	1137	FUNCTION: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. {ECO:0000269|PubMed:26447209}.	MISCELLANEOUS: [Isoform 5]: Incomplete sequence. {ECO:0000305}.	bicarbonate transport [GO:0015701]; cerebrospinal fluid secretion [GO:0033326]; epithelial cell development [GO:0002064]; mitochondrion distribution [GO:0048311]; regulation of gene expression [GO:0010468]; regulation of intracellular pH [GO:0051453]; regulation of systemic arterial blood pressure [GO:0003073]; renal system process [GO:0003014]; retina development in camera-type eye [GO:0060041]; transmembrane transport [GO:0055085]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]; bicarbonate transport [GO:0015701]; cerebrospinal fluid secretion [GO:0033326]; epithelial cell development [GO:0002064]; mitochondrion distribution [GO:0048311]; regulation of gene expression [GO:0010468]; regulation of intracellular pH [GO:0051453]; regulation of systemic arterial blood pressure [GO:0003073]; renal system process [GO:0003014]; retina development in camera-type eye [GO:0060041]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:17715183, ECO:0000269|PubMed:26447209}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q6RI88}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla. {ECO:0000269|PubMed:17715183}.
Q9BY08	reviewed	EBPL_HUMAN	Emopamil-binding protein-like (Emopamil-binding-related protein)	EBPL EBRP ERP	Homo sapiens (Human)	206	FUNCTION: Does not possess sterol isomerase activity and does not bind sigma ligands. {ECO:0000269|PubMed:12760743}.		sterol metabolic process [GO:0016125]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	cholestenol delta-isomerase activity [GO:0047750]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; cholestenol delta-isomerase activity [GO:0047750]; sterol metabolic process [GO:0016125]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12760743}; Multi-pass membrane protein {ECO:0000269|PubMed:12760743}.
Q9BY10	reviewed	S46A2_HUMAN	Solute carrier family 46 member 2 (Thymic stromal cotransporter homolog)	SLC46A2 TSCOT	Homo sapiens (Human)	475	FUNCTION: Proton-coupled transporter that delivers pathogen-associated or danger-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes or tissue injury (PubMed:28539433, PubMed:34235268). Has selectivity toward muropeptides that contain the amino acid diaminopimelic acid (DAP-type peptidoglycan muropeptides) including Tri-DAP and tracheal toxin (TCT), common in Gram-negative bacteria and Gram-positive bacilli. In the context of immune recognition of skin microbiota, shuttles bacterial muropeptides across the endolysosomal membranes into the cytosol for recognition by NOD1, triggering MYD88-dependent secretion of IL1A and neutrophil recruitment in a pyroptosis-type inflammatory process (PubMed:28539433). To a lesser extent and redundantly, transports muramyl dipeptides derived from most bacterial proteoglycans, eliciting NOD2 receptor activation and downstream inflammatory responses (PubMed:28539433). Postulated to function as a dominant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. Selectively imports cGAMPs derived from pathogenic bacteria such as 3'3'-cGAMP thus providing for differential immune recognition of pathogenic versus commensal bacteria. During tumorigenesis may transport extracellular tumor-derived 2'3'-cGAMP across the plasma membrane of M1-polarized macrophages to activate the anti-tumoral stimulator of interferon genes (STING) pathway (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable). {ECO:0000269|PubMed:28539433, ECO:0000269|PubMed:34235268, ECO:0000305}.		cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; innate immune response [GO:0045087]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; regulation of T cell differentiation [GO:0045580]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; transmembrane transport [GO:0055085]	cell surface [GO:0009986]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cyclic-GMP-AMP transmembrane transporter activity [GO:0140360]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]	cell surface [GO:0009986]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cyclic-GMP-AMP transmembrane transporter activity [GO:0140360]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; innate immune response [GO:0045087]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; regulation of T cell differentiation [GO:0045580]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:28539433}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:34235268}; Multi-pass membrane protein. Note=Localizes in acidic vesicles likely late endosomes and/or endolysosomes. {ECO:0000269|PubMed:28539433}.
Q9BY11	reviewed	PACN1_HUMAN	Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1)	PACSIN1 KIAA1379	Homo sapiens (Human)	444	FUNCTION: Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}.		actin filament organization [GO:0007015]; cytoskeleton organization [GO:0007010]; negative regulation of endocytosis [GO:0045806]; neuron projection morphogenesis [GO:0048812]; plasma membrane tubulation [GO:0097320]; positive regulation of dendrite development [GO:1900006]; protein localization to membrane [GO:0072657]; protein localization to plasma membrane [GO:0072659]; regulation of endocytosis [GO:0030100]; synaptic vesicle endocytosis [GO:0048488]	axon terminus [GO:0043679]; COPI-coated vesicle [GO:0030137]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynaptic endocytic zone [GO:0098833]; ruffle membrane [GO:0032587]; synapse [GO:0045202]	cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]	axon terminus [GO:0043679]; COPI-coated vesicle [GO:0030137]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynaptic endocytic zone [GO:0098833]; ruffle membrane [GO:0032587]; synapse [GO:0045202]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; actin filament organization [GO:0007015]; cytoskeleton organization [GO:0007010]; negative regulation of endocytosis [GO:0045806]; neuron projection morphogenesis [GO:0048812]; plasma membrane tubulation [GO:0097320]; positive regulation of dendrite development [GO:1900006]; protein localization to membrane [GO:0072657]; protein localization to plasma membrane [GO:0072659]; regulation of endocytosis [GO:0030100]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain. {ECO:0000250}.
Q9BY12	reviewed	SCAPE_HUMAN	S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291)	SCAPER KIAA1454 ZNF291 MSTP063	Homo sapiens (Human)	1400	FUNCTION: CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm. {ECO:0000269|PubMed:17698606}.		antral ovarian follicle growth [GO:0001547]; retina development in camera-type eye [GO:0060041]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; ooplasm [GO:1990917]; sperm head [GO:0061827]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; ooplasm [GO:1990917]; sperm head [GO:0061827]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; antral ovarian follicle growth [GO:0001547]; retina development in camera-type eye [GO:0060041]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:17698606}. Nucleus {ECO:0000269|PubMed:17698606}. Note=Predominantly located in the endoplasmic reticulum, only a small portion is detected in the nucleus.
Q9BY14	reviewed	TX101_HUMAN	Testis-expressed protein 101 (Cell surface receptor NYD-SP8) (Scleroderma-associated autoantigen) (Spermatogenesis-related gene protein)	TEX101 SGRG UNQ867/PRO1884	Homo sapiens (Human)	249	FUNCTION: Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q924B5, ECO:0000250|UniProtKB:Q9JMI7}.		binding of sperm to zona pellucida [GO:0007339]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; regulation of flagellated sperm motility [GO:1901317]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; side of membrane [GO:0098552]		acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; side of membrane [GO:0098552]; binding of sperm to zona pellucida [GO:0007339]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; regulation of flagellated sperm motility [GO:1901317]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9JMI7}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9JMI7}. Membrane raft {ECO:0000250|UniProtKB:Q9JMI7}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9JMI7}. Secreted {ECO:0000250|UniProtKB:Q9JMI7}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9JMI7}. Note=Located on plasma membrane of spermatocytes, round and elongated spermatids, and testicular spermatozoa. {ECO:0000250|UniProtKB:Q9JMI7}.
Q9BY15	reviewed	AGRE3_HUMAN	Adhesion G protein-coupled receptor E3 (EGF-like module receptor 3) (EGF-like module-containing mucin-like hormone receptor-like 3)	ADGRE3 EMR3 UNQ683/PRO1562	Homo sapiens (Human)	652	FUNCTION: Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils. {ECO:0000269|PubMed:11279179}.	MISCELLANEOUS: Has no murine ortholog. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Due to a 40-nucleotide deletion (nucleotides 439-479) resulting in a frameshift leading to a premature stop codon and the production of a truncated soluble form. {ECO:0000305}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]	extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Q9BY27	reviewed	DGC6L_HUMAN	Protein DGCR6L (DiGeorge syndrome critical region 6-like protein)	DGCR6L	Homo sapiens (Human)	220	FUNCTION: May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15821931}. Note=Predominantly nuclear.
Q9BY32	reviewed	ITPA_HUMAN	Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (Putative oncogene protein hlc14-06-p)	ITPA C20orf37 My049 OK/SW-cl.9	Homo sapiens (Human)	194	FUNCTION: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832, ECO:0000269|PubMed:17090528}.		chromosome organization [GO:0051276]; deoxyribonucleoside triphosphate catabolic process [GO:0009204]; ITP catabolic process [GO:0006193]; nucleoside triphosphate catabolic process [GO:0009143]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	dITP diphosphatase activity [GO:0035870]; identical protein binding [GO:0042802]; ITP diphosphatase activity [GO:0036220]; metal ion binding [GO:0046872]; nucleoside triphosphate diphosphatase activity [GO:0047429]; nucleotide binding [GO:0000166]; XTP diphosphatase activity [GO:0036222]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; dITP diphosphatase activity [GO:0035870]; identical protein binding [GO:0042802]; ITP diphosphatase activity [GO:0036220]; metal ion binding [GO:0046872]; nucleoside triphosphate diphosphatase activity [GO:0047429]; nucleotide binding [GO:0000166]; XTP diphosphatase activity [GO:0036222]; chromosome organization [GO:0051276]; deoxyribonucleoside triphosphate catabolic process [GO:0009204]; ITP catabolic process [GO:0006193]; nucleoside triphosphate catabolic process [GO:0009143]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832}.
Q9BY41	reviewed	HDAC8_HUMAN	Histone deacetylase 8 (HD8) (EC 3.5.1.98) (Protein deacetylase HDAC8) (EC 3.5.1.-) (Protein decrotonylase HDAC8) (EC 3.5.1.-)	HDAC8 HDACL1 CDA07	Homo sapiens (Human)	377	FUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748). Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin (PubMed:22885700). May play a role in smooth muscle cell contractility (PubMed:15772115). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (PubMed:28497810). {ECO:0000269|PubMed:10748112, ECO:0000269|PubMed:10922473, ECO:0000269|PubMed:10926844, ECO:0000269|PubMed:14701748, ECO:0000269|PubMed:15772115, ECO:0000269|PubMed:22885700, ECO:0000269|PubMed:28497810}.		chromatin organization [GO:0006325]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of protein stability [GO:0031647]; regulation of telomere maintenance [GO:0032204]	cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone decrotonylase activity [GO:0160009]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872]; protein lysine deacetylase activity [GO:0033558]	cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone decrotonylase activity [GO:0160009]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872]; protein lysine deacetylase activity [GO:0033558]; chromatin organization [GO:0006325]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of protein stability [GO:0031647]; regulation of telomere maintenance [GO:0032204]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10748112, ECO:0000269|PubMed:14701748}. Chromosome {ECO:0000269|PubMed:10748112}. Cytoplasm {ECO:0000269|PubMed:15772115, ECO:0000269|PubMed:16538051}. Note=Excluded from the nucleoli (PubMed:10748112). Found in the cytoplasm of cells showing smooth muscle differentiation (PubMed:15772115, PubMed:16538051). {ECO:0000269|PubMed:10748112, ECO:0000269|PubMed:15772115, ECO:0000269|PubMed:16538051}.
Q9BY42	reviewed	RTF2_HUMAN	Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1)	RTF2 C20orf43 RTFDC1 AD-007 CDA05 HSPC164 HSPC169	Homo sapiens (Human)	306	FUNCTION: Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}.		cellular response to hydroxyurea [GO:0072711]; mitotic DNA replication termination [GO:1902979]; regulation of DNA stability [GO:0097752]	nucleus [GO:0005634]; replication fork [GO:0005657]	DNA binding [GO:0003677]	nucleus [GO:0005634]; replication fork [GO:0005657]; DNA binding [GO:0003677]; cellular response to hydroxyurea [GO:0072711]; mitotic DNA replication termination [GO:1902979]; regulation of DNA stability [GO:0097752]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:29290612}. Note=Localizes at the replication fork. {ECO:0000269|PubMed:29290612}.
Q9BY43	reviewed	CHM4A_HUMAN	Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1)	CHMP4A C14orf123 SHAX2 CDA04 HSPC134	Homo sapiens (Human)	222	FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:22660413}.		autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; membrane invagination [GO:0010324]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nervous system process [GO:0050877]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; plasma membrane tubulation [GO:0097320]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein polymerization [GO:0051258]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; membrane invagination [GO:0010324]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nervous system process [GO:0050877]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; plasma membrane tubulation [GO:0097320]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein polymerization [GO:0051258]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated. Localizes to large vesicle-like structures. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Q9BY44	reviewed	EIF2A_HUMAN	Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed]	EIF2A CDA02 MSTP004 MSTP089	Homo sapiens (Human)	585	FUNCTION: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. {ECO:0000269|PubMed:12133843}.		positive regulation of signal transduction [GO:0009967]; regulation of translation [GO:0006417]; response to amino acid starvation [GO:1990928]; ribosome assembly [GO:0042255]; SREBP signaling pathway [GO:0032933]; translational initiation [GO:0006413]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosolic small ribosomal subunit [GO:0022627]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular space [GO:0005615]	cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosolic small ribosomal subunit [GO:0022627]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular space [GO:0005615]; cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049]; positive regulation of signal transduction [GO:0009967]; regulation of translation [GO:0006417]; response to amino acid starvation [GO:1990928]; ribosome assembly [GO:0042255]; SREBP signaling pathway [GO:0032933]; translational initiation [GO:0006413]	
Q9BY49	reviewed	PECR_HUMAN	Peroxisomal trans-2-enoyl-CoA reductase (TERP) (EC 1.3.1.38) (2,4-dienoyl-CoA reductase-related protein) (DCR-RP) (HPDHase) (Short chain dehydrogenase/reductase family 29C member 1) (pVI-ARL)	PECR SDR29C1 PRO1004	Homo sapiens (Human)	303	FUNCTION: Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity. {ECO:0000269|PubMed:10811639}.		fatty acid biosynthetic process [GO:0006633]; phytol metabolic process [GO:0033306]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	signaling receptor binding [GO:0005102]; trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; signaling receptor binding [GO:0005102]; trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166]; fatty acid biosynthetic process [GO:0006633]; phytol metabolic process [GO:0033306]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:11669066}.
Q9BY50	reviewed	SC11C_HUMAN	Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21)	SEC11C SEC11L3 SPC21 SPCS4C	Homo sapiens (Human)	192	FUNCTION: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (PubMed:34388369). {ECO:0000269|PubMed:34388369}.		signal peptide processing [GO:0006465]	endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; signal peptide processing [GO:0006465]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P13679}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P13679}.
Q9BY64	reviewed	UDB28_HUMAN	UDP-glucuronosyltransferase 2B28 (UDPGT 2B28) (UGT2B28) (EC 2.4.1.17)	UGT2B28	Homo sapiens (Human)	529	FUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:11300766). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:11300766). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (androsterone, 3alpha-androstanediol) and estrogens (estradiol, estrone) (PubMed:11300766). Catalyzes the glucuronidation of bile acid substrates, which are natural detergents for dietary lipids absorption (PubMed:11300766). Displays glucuronidation activity toward the phenolic compounds eugenol (PubMed:11300766). {ECO:0000269|PubMed:11300766}.; FUNCTION: [Isoform 2]: Lack UDP-glucuronosyltransferase (UGT) activity. {ECO:0000269|PubMed:11300766}.		cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; steroid metabolic process [GO:0008202]; xenobiotic glucuronidation [GO:0052697]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear outer membrane [GO:0005640]; perinuclear region of cytoplasm [GO:0048471]	glucuronosyltransferase activity [GO:0015020]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear outer membrane [GO:0005640]; perinuclear region of cytoplasm [GO:0048471]; glucuronosyltransferase activity [GO:0015020]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; steroid metabolic process [GO:0008202]; xenobiotic glucuronidation [GO:0052697]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11300766}; Single-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11300766}.
Q9BY66	reviewed	KDM5D_HUMAN	Lysine-specific demethylase 5D (EC 1.14.11.67) (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY) ([histone H3]-trimethyl-L-lysine(4) demethylase 5D)	KDM5D HY HYA JARID1D KIAA0234 SMCY	Homo sapiens (Human)	1539	FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. {ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:17351630, ECO:0000269|PubMed:26747897, ECO:0000269|PubMed:27185910, ECO:0000269|PubMed:27427228, ECO:0000269|PubMed:27477906}.	MISCELLANEOUS: Involved in sensitivity to docetaxel. {ECO:0000269|PubMed:27185910}.	chromatin remodeling [GO:0006338]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of DNA-templated transcription [GO:0006355]; T cell antigen processing and presentation [GO:0002457]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; chromatin remodeling [GO:0006338]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of DNA-templated transcription [GO:0006355]; T cell antigen processing and presentation [GO:0002457]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27185910, ECO:0000269|PubMed:27477906, ECO:0000305}.
Q9BY67	reviewed	CADM1_HUMAN	Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)	CADM1 IGSF4 IGSF4A NECL2 SYNCAM TSLC1	Homo sapiens (Human)	442	FUNCTION: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:22438059, PubMed:12050160). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:22438059). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed:11279526, PubMed:12234973). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed:12920246). {ECO:0000250|UniProtKB:Q8R5M8, ECO:0000269|PubMed:11279526, ECO:0000269|PubMed:12050160, ECO:0000269|PubMed:12234973, ECO:0000269|PubMed:12920246, ECO:0000269|PubMed:15811952, ECO:0000269|PubMed:15905536, ECO:0000269|PubMed:22438059}.		apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell recognition [GO:0008037]; detection of stimulus [GO:0051606]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune system process [GO:0002376]; liver development [GO:0001889]; negative regulation of ERBB4 signaling pathway [GO:0120154]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cytokine production [GO:0001819]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; spermatogenesis [GO:0007283]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271]	basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	cell adhesion molecule binding [GO:0050839]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]	basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202]; cell adhesion molecule binding [GO:0050839]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell recognition [GO:0008037]; detection of stimulus [GO:0051606]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune system process [GO:0002376]; liver development [GO:0001889]; negative regulation of ERBB4 signaling pathway [GO:0120154]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cytokine production [GO:0001819]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; spermatogenesis [GO:0007283]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11279526, ECO:0000269|PubMed:22438059}; Single-pass type I membrane protein {ECO:0000269|PubMed:11279526}. Synapse {ECO:0000250|UniProtKB:Q8R5M8}. Note=Localized to the basolateral plasma membrane of epithelial cells in gall bladder. {ECO:0000250|UniProtKB:Q8R5M8}.
Q9BY76	reviewed	ANGL4_HUMAN	Angiopoietin-related protein 4 (Angiopoietin-like protein 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP) [Cleaved into: ANGPTL4 N-terminal chain; ANGPTL4 C-terminal chain]	ANGPTL4 ARP4 HFARP PGAR PP1158 PSEC0166 UNQ171/PRO197	Homo sapiens (Human)	406	FUNCTION: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (PubMed:14583458, PubMed:17068295). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (PubMed:17068295). Depending on context, may modulate tumor-related angiogenesis (By similarity). {ECO:0000250|UniProtKB:Q9Z1P8, ECO:0000269|PubMed:14583458, ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:19270337, ECO:0000269|PubMed:21398697, ECO:0000269|PubMed:27929370, ECO:0000269|PubMed:29899144, ECO:0000305|PubMed:29899519}.; FUNCTION: [ANGPTL4 N-terminal chain]: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). Has higher activity in LPL inactivation than the uncleaved protein (PubMed:19270337, PubMed:21398697). {ECO:0000269|PubMed:19270337, ECO:0000269|PubMed:21398697, ECO:0000269|PubMed:27929370, ECO:0000269|PubMed:29899144}.		angiogenesis [GO:0001525]; endothelial cell apoptotic process [GO:0072577]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of lipoprotein lipase activity [GO:0051005]; positive regulation of angiogenesis [GO:0045766]; protein unfolding [GO:0043335]; response to hypoxia [GO:0001666]; triglyceride homeostasis [GO:0070328]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]	blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; angiogenesis [GO:0001525]; endothelial cell apoptotic process [GO:0072577]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of lipoprotein lipase activity [GO:0051005]; positive regulation of angiogenesis [GO:0045766]; protein unfolding [GO:0043335]; response to hypoxia [GO:0001666]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10698685, ECO:0000269|PubMed:14583458, ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:19270337, ECO:0000269|PubMed:21398697, ECO:0000269|PubMed:29899519}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:21398697}. Note=The unprocessed form interacts with the extracellular matrix (PubMed:17068295, PubMed:21398697). This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (Probable). {ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:21398697, ECO:0000305|PubMed:17068295}.
Q9BY77	reviewed	PDIP3_HUMAN	Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR)	POLDIP3 KIAA1649 PDIP46	Homo sapiens (Human)	421	FUNCTION: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}.		poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of translation [GO:0045727]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of translation [GO:0045727]	SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein.
Q9BY78	reviewed	RNF26_HUMAN	E3 ubiquitin-protein ligase RNF26 (EC 2.3.2.27) (RING finger protein 26)	RNF26	Homo sapiens (Human)	433	FUNCTION: E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102). Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1 (PubMed:27368102, PubMed:33472082). Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379, PubMed:32614325). Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379). {ECO:0000269|PubMed:25254379, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:32614325, ECO:0000269|PubMed:33472082}.		endosome organization [GO:0007032]; negative regulation of defense response to virus [GO:0050687]; protein K11-linked ubiquitination [GO:0070979]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein ubiquitination [GO:0016567]; regulation of type I interferon production [GO:0032479]; ubiquitin-dependent protein catabolic process [GO:0006511]	endoplasmic reticulum membrane [GO:0005789]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	endoplasmic reticulum membrane [GO:0005789]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; endosome organization [GO:0007032]; negative regulation of defense response to virus [GO:0050687]; protein K11-linked ubiquitination [GO:0070979]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein ubiquitination [GO:0016567]; regulation of type I interferon production [GO:0032479]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25254379, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:32614325}; Multi-pass membrane protein {ECO:0000255}.
Q9BY79	reviewed	MFRP_HUMAN	Membrane frizzled-related protein (Membrane-type frizzled-related protein)	MFRP	Homo sapiens (Human)	579	FUNCTION: May play a role in eye development. {ECO:0000269|PubMed:15976030}.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the C1QTNF5 protein from a non-overlapping reading frame.	embryo development ending in birth or egg hatching [GO:0009792]; eye photoreceptor cell development [GO:0042462]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]		apical plasma membrane [GO:0016324]; membrane [GO:0016020]; embryo development ending in birth or egg hatching [GO:0009792]; eye photoreceptor cell development [GO:0042462]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9BY84	reviewed	DUS16_HUMAN	Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7)	DUSP16 KIAA1700 MKP7	Homo sapiens (Human)	665	FUNCTION: Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. {ECO:0000269|PubMed:11489891, ECO:0000269|PubMed:15888437}.		dephosphorylation [GO:0016311]; MAPK export from nucleus [GO:0045204]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	JUN kinase binding [GO:0008432]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; mitogen-activated protein kinase binding [GO:0051019]; mitogen-activated protein kinase p38 binding [GO:0048273]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine/threonine phosphatase activity [GO:0008330]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; JUN kinase binding [GO:0008432]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; mitogen-activated protein kinase binding [GO:0051019]; mitogen-activated protein kinase p38 binding [GO:0048273]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine/threonine phosphatase activity [GO:0008330]; dephosphorylation [GO:0016311]; MAPK export from nucleus [GO:0045204]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.
Q9BYB0	reviewed	SHAN3_HUMAN	SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)	SHANK3 KIAA1650 PROSAP2 PSAP2	Homo sapiens (Human)	1731	FUNCTION: Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.	MISCELLANEOUS: [Isoform 1]: Primarily expressed in neurons.; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000305}.	adult behavior [GO:0030534]; AMPA glutamate receptor clustering [GO:0097113]; brain morphogenesis [GO:0048854]; dendritic spine morphogenesis [GO:0060997]; guanylate kinase-associated protein clustering [GO:0097117]; learning [GO:0007612]; MAPK cascade [GO:0000165]; memory [GO:0007613]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of cell volume [GO:0045794]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of AMPA receptor activity [GO:2000969]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of glutamate receptor signaling pathway [GO:1900451]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synapse structural plasticity [GO:0051835]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density assembly [GO:0097107]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of long-term synaptic depression [GO:1900452]; regulation of long-term synaptic potentiation [GO:1900271]; social behavior [GO:0035176]; striatal medium spiny neuron differentiation [GO:0021773]; synapse assembly [GO:0007416]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]	ciliary membrane [GO:0060170]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; neuron projection [GO:0043005]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	actin binding [GO:0003779]; ionotropic glutamate receptor binding [GO:0035255]; protein self-association [GO:0043621]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; synaptic receptor adaptor activity [GO:0030160]; zinc ion binding [GO:0008270]	ciliary membrane [GO:0060170]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; neuron projection [GO:0043005]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; actin binding [GO:0003779]; ionotropic glutamate receptor binding [GO:0035255]; protein self-association [GO:0043621]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; synaptic receptor adaptor activity [GO:0030160]; zinc ion binding [GO:0008270]; adult behavior [GO:0030534]; AMPA glutamate receptor clustering [GO:0097113]; brain morphogenesis [GO:0048854]; dendritic spine morphogenesis [GO:0060997]; guanylate kinase-associated protein clustering [GO:0097117]; learning [GO:0007612]; MAPK cascade [GO:0000165]; memory [GO:0007613]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of cell volume [GO:0045794]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of AMPA receptor activity [GO:2000969]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of glutamate receptor signaling pathway [GO:1900451]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synapse structural plasticity [GO:0051835]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density assembly [GO:0097107]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of long-term synaptic depression [GO:1900452]; regulation of long-term synaptic potentiation [GO:1900271]; social behavior [GO:0035176]; striatal medium spiny neuron differentiation [GO:0021773]; synapse assembly [GO:0007416]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24132240}. Postsynaptic density {ECO:0000269|PubMed:24132240}. Cell projection, dendritic spine {ECO:0000250}. Note=In neuronal cells, extends into the region subjacent to the postsynaptic density (PSD). {ECO:0000250}.
Q9BYC5	reviewed	FUT8_HUMAN	Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase)	FUT8	Homo sapiens (Human)	575	FUNCTION: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. {ECO:0000269|PubMed:17172260, ECO:0000269|PubMed:29304374, ECO:0000269|PubMed:9133635}.	MISCELLANEOUS: [Isoform 4]: Seems to be only expressed in retina, inactive as a fucosyltransferase. {ECO:0000305}.	fibroblast migration [GO:0010761]; GDP-L-fucose metabolic process [GO:0046368]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; L-fucose catabolic process [GO:0042355]; N-glycan fucosylation [GO:0036071]; N-glycan processing [GO:0006491]; oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; receptor metabolic process [GO:0043112]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of gene expression [GO:0010468]; respiratory gaseous exchange by respiratory system [GO:0007585]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral protein processing [GO:0019082]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	alpha-(1->6)-fucosyltransferase activity [GO:0046921]; glycoprotein 6-alpha-L-fucosyltransferase activity [GO:0008424]; SH3 domain binding [GO:0017124]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; alpha-(1->6)-fucosyltransferase activity [GO:0046921]; glycoprotein 6-alpha-L-fucosyltransferase activity [GO:0008424]; SH3 domain binding [GO:0017124]; fibroblast migration [GO:0010761]; GDP-L-fucose metabolic process [GO:0046368]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; L-fucose catabolic process [GO:0042355]; N-glycan fucosylation [GO:0036071]; N-glycan processing [GO:0006491]; oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; receptor metabolic process [GO:0043112]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of gene expression [GO:0010468]; respiratory gaseous exchange by respiratory system [GO:0007585]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.
Q9BYD5	reviewed	CNFN_HUMAN	Cornifelin	CNFN	Homo sapiens (Human)	112	FUNCTION: Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. {ECO:0000269|PubMed:15147942}.		keratinization [GO:0031424]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]		cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; keratinization [GO:0031424]	SUBCELLULAR LOCATION: Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope. {ECO:0000250}.
Q9BYE0	reviewed	HES7_HUMAN	Transcription factor HES-7 (hHes7) (Class B basic helix-loop-helix protein 37) (bHLHb37) (Hairy and enhancer of split 7) (bHLH factor Hes7)	HES7 BHLHB37	Homo sapiens (Human)	225	FUNCTION: Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation (By similarity). {ECO:0000250}.		anterior/posterior pattern specification [GO:0009952]; mesoderm development [GO:0007498]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; post-anal tail morphogenesis [GO:0036342]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; skeletal system development [GO:0001501]; somitogenesis [GO:0001756]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; mesoderm development [GO:0007498]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; post-anal tail morphogenesis [GO:0036342]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; skeletal system development [GO:0001501]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BYE2	reviewed	TMPSD_HUMAN	Transmembrane protease serine 13 (EC 3.4.21.-) (Membrane-type mosaic serine protease) (Mosaic serine protease)	TMPRSS13 MSP TMPRSS11	Homo sapiens (Human)	586	FUNCTION: Serine protease (PubMed:20977675, PubMed:28710277, PubMed:34562451). Cleaves the proform of PRSS8/prostasin to form the active protein (PubMed:34562451). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (PubMed:20977675). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (By similarity). {ECO:0000250|UniProtKB:Q5U405, ECO:0000269|PubMed:20977675, ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:34562451}.		proteolysis [GO:0006508]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:34562451, ECO:0000269|PubMed:35796294}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:35796294}. Cytoplasm {ECO:0000269|PubMed:28710277}. Note=The non-phosphorylated, inactive full length protein localizes intracellularly (PubMed:28710277). N-glycosylation and phosphorylation is required for trafficking to the cell surface (PubMed:28710277, PubMed:34562451, PubMed:35796294). Interaction with SPINT1/HAI-1 and SPINT2/HAI-2 facilitate its translocation to the cell surface (PubMed:34562451, PubMed:35796294). Proteolytic cleavage is required for secretion (PubMed:35796294). {ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:34562451, ECO:0000269|PubMed:35796294}.
Q9BYE3	reviewed	LCE3D_HUMAN	Late cornified envelope protein 3D (Late envelope protein 16) (Small proline-rich-like epidermal differentiation complex protein 6A) (Small proline-rich-like epidermal differentiation complex protein 6B)	LCE3D LEP16 SPRL6A SPRL6B	Homo sapiens (Human)	92	FUNCTION: Precursors of the cornified envelope of the stratum corneum.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]	cytosol [GO:0005829]		cytosol [GO:0005829]; keratinization [GO:0031424]	
Q9BYE7	reviewed	PCGF6_HUMAN	Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)	PCGF6 MBLR RNF134	Homo sapiens (Human)	350	FUNCTION: Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:26151332}.		chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]	metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; metal ion binding [GO:0046872]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:21282530}.
Q9BYE9	reviewed	CDHR2_HUMAN	Cadherin-related family member 2 (Protocadherin LKC) (PC-LKC) (Protocadherin-24)	CDHR2 PCDH24 PCLKC	Homo sapiens (Human)	1310	FUNCTION: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771). {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}.		cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; negative regulation of cell growth involved in contact inhibition [GO:0060243]; regulation of microvillus length [GO:0032532]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; negative regulation of cell growth involved in contact inhibition [GO:0060243]; regulation of microvillus length [GO:0032532]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}. Cell projection, microvillus membrane {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}. Cell junction {ECO:0000269|PubMed:12117771}.
Q9BYF1	reviewed	ACE2_HUMAN	Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2]	ACE2 UNQ868/PRO1885	Homo sapiens (Human)	805	FUNCTION: Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10969042, PubMed:10924499, PubMed:11815627, PubMed:19021774, PubMed:14504186). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582). {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:11815627, ECO:0000269|PubMed:14504186, ECO:0000269|PubMed:18424768, ECO:0000269|PubMed:19021774, ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:27217402}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. {ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:15452268, ECO:0000269|PubMed:15791205, ECO:0000269|PubMed:15897467, ECO:0000269|PubMed:19901337, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32221306, ECO:0000269|PubMed:32225175, ECO:0000269|PubMed:33000221, ECO:0000269|PubMed:33082294, ECO:0000269|PubMed:33432067}.; FUNCTION: [Isoform 2]: Non-functional as a carboxypeptidase. {ECO:0000269|PubMed:33077916}.; FUNCTION: [Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33077916, ECO:0000269|PubMed:33432184}.		angiotensin maturation [GO:0002003]; angiotensin-mediated drinking behavior [GO:0003051]; blood vessel diameter maintenance [GO:0097746]; entry receptor-mediated virion attachment to host cell [GO:0098670]; maternal process involved in female pregnancy [GO:0060135]; membrane fusion [GO:0061025]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of amino acid transport [GO:0051957]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of L-proline import across plasma membrane [GO:1905737]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; receptor-mediated virion attachment to host cell [GO:0046813]; regulation of cardiac conduction [GO:1903779]; regulation of cell population proliferation [GO:0042127]; regulation of cytokine production [GO:0001817]; regulation of inflammatory response [GO:0050727]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; regulation of transmembrane transporter activity [GO:0022898]; regulation of vasoconstriction [GO:0019229]; tryptophan transport [GO:0015827]; viral entry into host cell [GO:0046718]; viral life cycle [GO:0019058]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cilium [GO:0005929]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	carboxypeptidase activity [GO:0004180]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; metallocarboxypeptidase activity [GO:0004181]; metallopeptidase activity [GO:0008237]; peptidyl-dipeptidase activity [GO:0008241]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cilium [GO:0005929]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; carboxypeptidase activity [GO:0004180]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; metallocarboxypeptidase activity [GO:0004181]; metallopeptidase activity [GO:0008237]; peptidyl-dipeptidase activity [GO:0008241]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]; angiotensin maturation [GO:0002003]; angiotensin-mediated drinking behavior [GO:0003051]; blood vessel diameter maintenance [GO:0097746]; entry receptor-mediated virion attachment to host cell [GO:0098670]; maternal process involved in female pregnancy [GO:0060135]; membrane fusion [GO:0061025]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of amino acid transport [GO:0051957]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of L-proline import across plasma membrane [GO:1905737]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; receptor-mediated virion attachment to host cell [GO:0046813]; regulation of cardiac conduction [GO:1903779]; regulation of cell population proliferation [GO:0042127]; regulation of cytokine production [GO:0001817]; regulation of inflammatory response [GO:0050727]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; regulation of transmembrane transporter activity [GO:0022898]; regulation of vasoconstriction [GO:0019229]; tryptophan transport [GO:0015827]; viral entry into host cell [GO:0046718]; viral life cycle [GO:0019058]	SUBCELLULAR LOCATION: [Processed angiotensin-converting enzyme 2]: Secreted {ECO:0000269|PubMed:15983030, ECO:0000269|PubMed:33713620}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18424768}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8R0I0}. Cell projection, cilium {ECO:0000269|PubMed:33432184}. Apical cell membrane {ECO:0000269|PubMed:33432184}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250|UniProtKB:Q8R0I0}.; SUBCELLULAR LOCATION: [Isoform 2]: Apical cell membrane {ECO:0000269|PubMed:33432184}.
Q9BYG0	reviewed	B3GN5_HUMAN	Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylglucosaminyltransferase 5) (Beta3Gn-T5)	B3GNT5	Homo sapiens (Human)	378	FUNCTION: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development. {ECO:0000269|PubMed:11283017, ECO:0000269|PubMed:11384981}.		central nervous system development [GO:0007417]; glycolipid biosynthetic process [GO:0009247]; O-glycan processing [GO:0016266]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity [GO:0008457]; lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity [GO:0047256]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity [GO:0008457]; lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity [GO:0047256]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; central nervous system development [GO:0007417]; glycolipid biosynthetic process [GO:0009247]; O-glycan processing [GO:0016266]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9BYG3	reviewed	MK67I_HUMAN	MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK)	NIFK MKI67IP NOPP34	Homo sapiens (Human)	293			maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; protein-containing complex assembly [GO:0065003]; rRNA metabolic process [GO:0016072]; rRNA transcription [GO:0009303]	chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; protein-containing complex assembly [GO:0065003]; rRNA metabolic process [GO:0016072]; rRNA transcription [GO:0009303]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67.
Q9BYG4	reviewed	PAR6G_HUMAN	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)	PARD6G PAR6G	Homo sapiens (Human)	376	FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). {ECO:0000250}.		cell division [GO:0051301]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; regulation of cellular localization [GO:0060341]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cytosol [GO:0005829]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; tight junction [GO:0070160]		apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cytosol [GO:0005829]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; tight junction [GO:0070160]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; regulation of cellular localization [GO:0060341]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}.
Q9BYG5	reviewed	PAR6B_HUMAN	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)	PARD6B PAR6B	Homo sapiens (Human)	372	FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.		axonogenesis [GO:0007409]; cell division [GO:0051301]; cell-cell junction assembly [GO:0007043]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; protein-containing complex assembly [GO:0065003]; regulation of cell migration [GO:0030334]; regulation of cellular localization [GO:0060341]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; tight junction [GO:0070160]		apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; tight junction [GO:0070160]; axonogenesis [GO:0007409]; cell division [GO:0051301]; cell-cell junction assembly [GO:0007043]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; protein-containing complex assembly [GO:0065003]; regulation of cell migration [GO:0030334]; regulation of cellular localization [GO:0060341]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}.
Q9BYG8	reviewed	GSDMC_HUMAN	Gasdermin-C (Melanoma-derived leucine zipper-containing extranuclear factor) [Cleaved into: Gasdermin-C, N-terminal (GSDMC-NT); Gasdermin-C, C-terminal (GSDMC-CT)]	GSDMC MLZE	Homo sapiens (Human)	508	FUNCTION: [Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis. {ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073}.; FUNCTION: [Gasdermin-C, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:27281216, PubMed:32929201, PubMed:34012073). Produced by the cleavage of gasdermin-D by caspase CASP8 in response to death signals (PubMed:32929201, PubMed:34012073). After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids (PubMed:32929201, PubMed:34012073). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:32929201, PubMed:34012073). {ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073}.		defense response to bacterium [GO:0042742]; pyroptosis [GO:0070269]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; defense response to bacterium [GO:0042742]; pyroptosis [GO:0070269]	SUBCELLULAR LOCATION: [Gasdermin-C]: Cytoplasm, cytosol {ECO:0000269|PubMed:11223543}.; SUBCELLULAR LOCATION: [Gasdermin-C, N-terminal]: Cell membrane {ECO:0000269|PubMed:32929201}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
Q9BYH1	reviewed	SE6L1_HUMAN	Seizure 6-like protein	SEZ6L KIAA0927 UNQ2542/PRO6094	Homo sapiens (Human)	1024	FUNCTION: May contribute to specialized endoplasmic reticulum functions in neurons. {ECO:0000250}.		regulation of protein kinase C signaling [GO:0090036]; synapse maturation [GO:0060074]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; regulation of protein kinase C signaling [GO:0090036]; synapse maturation [GO:0060074]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9BYH8	reviewed	IKBZ_HUMAN	NF-kappa-B inhibitor zeta (I-kappa-B-zeta) (IkB-zeta) (IkappaBzeta) (IL-1 inducible nuclear ankyrin-repeat protein) (INAP) (Molecule possessing ankyrin repeats induced by lipopolysaccharide) (MAIL)	NFKBIZ IKBZ INAP MAIL	Homo sapiens (Human)	718	FUNCTION: Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:16513645, PubMed:16622025). Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:16513645). Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:16513645). Seems also to activate NF-kappa-B-mediated transcription (PubMed:16622025). In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (PubMed:16622025). Promotes transcription of LCN2 and DEFB4 (PubMed:16622025). Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity). {ECO:0000250|UniProtKB:Q9EST8, ECO:0000269|PubMed:16513645, ECO:0000269|PubMed:16622025}.		B cell proliferation [GO:0042100]; B cell receptor apoptotic signaling pathway [GO:1990117]; cellular response to interleukin-17 [GO:0097398]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chromatin remodeling [GO:0006338]; chronic inflammatory response [GO:0002544]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; epithelial cell apoptotic process [GO:1904019]; establishment of skin barrier [GO:0061436]; execution phase of apoptosis [GO:0097194]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response to wounding [GO:0090594]; isotype switching [GO:0045190]; keratinocyte activation [GO:0032980]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; mRNA transcription by RNA polymerase II [GO:0042789]; plasma cell differentiation [GO:0002317]; positive regulation of inflammatory response [GO:0050729]; positive regulation of T-helper 17 cell differentiation [GO:2000321]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; response to cisplatin [GO:0072718]; response to folic acid [GO:0051593]; response to Gram-positive bacterium [GO:0140459]; response to xenobiotic stimulus [GO:0009410]; spleen development [GO:0048536]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 cell differentiation [GO:0045063]; T-helper 17 cell differentiation [GO:0072539]; toll-like receptor signaling pathway [GO:0002224]; transcription preinitiation complex assembly [GO:0070897]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	POU domain binding [GO:0070974]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; POU domain binding [GO:0070974]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; B cell proliferation [GO:0042100]; B cell receptor apoptotic signaling pathway [GO:1990117]; cellular response to interleukin-17 [GO:0097398]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chromatin remodeling [GO:0006338]; chronic inflammatory response [GO:0002544]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; epithelial cell apoptotic process [GO:1904019]; establishment of skin barrier [GO:0061436]; execution phase of apoptosis [GO:0097194]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response to wounding [GO:0090594]; isotype switching [GO:0045190]; keratinocyte activation [GO:0032980]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; mRNA transcription by RNA polymerase II [GO:0042789]; plasma cell differentiation [GO:0002317]; positive regulation of inflammatory response [GO:0050729]; positive regulation of T-helper 17 cell differentiation [GO:2000321]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; response to cisplatin [GO:0072718]; response to folic acid [GO:0051593]; response to Gram-positive bacterium [GO:0140459]; response to xenobiotic stimulus [GO:0009410]; spleen development [GO:0048536]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 cell differentiation [GO:0045063]; T-helper 17 cell differentiation [GO:0072539]; toll-like receptor signaling pathway [GO:0002224]; transcription preinitiation complex assembly [GO:0070897]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16513645}. Note=Aggregated in dot-like structures (PubMed:16513645). Colocalizes with NCOR2 (PubMed:16513645). {ECO:0000269|PubMed:16513645}.
Q9BYI3	reviewed	HYCCI_HUMAN	Hyccin (Down-regulated by CTNNB1 protein A)	HYCC1 DRCTNNB1A FAM126A	Homo sapiens (Human)	521	FUNCTION: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211, ECO:0000305|PubMed:10910037}.		myelination [GO:0042552]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; myelination [GO:0042552]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10910037, ECO:0000269|PubMed:26571211}. Cell membrane {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211}. Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex. {ECO:0000269|PubMed:26571211}.
Q9BYJ1	reviewed	LOXE3_HUMAN	Hydroperoxide isomerase ALOXE3 (Epidermis-type lipoxygenase 3) (Epidermal LOX-3) (e-LOX-3) (eLOX-3) (Hydroperoxy dehydratase ALOXE3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7)	ALOXE3	Homo sapiens (Human)	711	FUNCTION: Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity (PubMed:12881489, PubMed:17045234, PubMed:20921226, PubMed:20923767). The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones (PubMed:12881489, PubMed:17045234, PubMed:20923767). In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides (PubMed:20921226). In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (PubMed:21558561). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:21558561). In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (PubMed:21558561). Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity). {ECO:0000250|UniProtKB:D3ZKX9, ECO:0000250|UniProtKB:Q9WV07, ECO:0000269|PubMed:12881489, ECO:0000269|PubMed:17045234, ECO:0000269|PubMed:20921226, ECO:0000269|PubMed:20923767, ECO:0000269|PubMed:21558561}.		arachidonic acid metabolic process [GO:0019369]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; fat cell differentiation [GO:0045444]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid oxidation [GO:0034440]; lipoxygenase pathway [GO:0019372]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; sensory perception of pain [GO:0019233]; sphingolipid metabolic process [GO:0006665]	cytosol [GO:0005829]	hepoxilin A3 synthase activity [GO:0051120]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; hydroperoxy icosatetraenoate isomerase activity [GO:0106255]; intramolecular transferase activity, transferring hydroxy groups [GO:0050486]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]	cytosol [GO:0005829]; hepoxilin A3 synthase activity [GO:0051120]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; hydroperoxy icosatetraenoate isomerase activity [GO:0106255]; intramolecular transferase activity, transferring hydroxy groups [GO:0050486]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; arachidonic acid metabolic process [GO:0019369]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; fat cell differentiation [GO:0045444]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid oxidation [GO:0034440]; lipoxygenase pathway [GO:0019372]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; sensory perception of pain [GO:0019233]; sphingolipid metabolic process [GO:0006665]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00726}.
Q9BYJ4	reviewed	TRI34_HUMAN	E3 ubiquitin-protein ligase TRIM34 (EC 2.3.2.27) (Interferon-responsive finger protein 1) (RING finger protein 21)	TRIM34 IFP1 RNF21	Homo sapiens (Human)	488	FUNCTION: Functions as antiviral protein and contributes to the defense against retroviral infections (PubMed:17156811, PubMed:32282853). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses (PubMed:32282853). During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination (PubMed:35065966). In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (PubMed:35065966). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis (PubMed:31956709). Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (PubMed:31487507). {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:31487507, ECO:0000269|PubMed:31956709, ECO:0000269|PubMed:32282853, ECO:0000269|PubMed:35065966}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein ubiquitination [GO:0016567]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein ubiquitination [GO:0016567]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:31487507, ECO:0000269|PubMed:32282853}. Mitochondrion {ECO:0000269|PubMed:31956709}. Note=Localizes in cytoplasmic bodies together with TRIM5 and incoming HIV-1 capsids during infection. {ECO:0000269|PubMed:32282853}.
Q9BYJ9	reviewed	YTHD1_HUMAN	YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1)	YTHDF1 C20orf21	Homo sapiens (Human)	559	FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:32492408, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31388144, PubMed:31292544, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). {ECO:0000250|UniProtKB:P59326, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.		immune system process [GO:0002376]; learning [GO:0007612]; memory [GO:0007613]; mRNA destabilization [GO:0061157]; organelle assembly [GO:0070925]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of antigen processing and presentation [GO:0002577]; regulation of axon guidance [GO:1902667]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of mRNA stability [GO:0043488]; stress granule assembly [GO:0034063]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932]	mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; immune system process [GO:0002376]; learning [GO:0007612]; memory [GO:0007613]; mRNA destabilization [GO:0061157]; organelle assembly [GO:0070925]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of antigen processing and presentation [GO:0002577]; regulation of axon guidance [GO:1902667]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of mRNA stability [GO:0043488]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32492408}. Cytoplasm, P-body {ECO:0000269|PubMed:32492408}. Cytoplasm, Stress granule {ECO:0000269|PubMed:32451507}.
Q9BYK8	reviewed	HELZ2_HUMAN	Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)	HELZ2 KIAA1769 PRIC285	Homo sapiens (Human)	2649	FUNCTION: Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. {ECO:0000269|PubMed:16239304, ECO:0000269|PubMed:23525231}.	MISCELLANEOUS: [Isoform 1]: More abundantly expressed than isoform 2.	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; P granule [GO:0043186]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; P granule [GO:0043186]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23525231}.
Q9BYM8	reviewed	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3)	RBCK1 C20orf18 RNF54 UBCE7IP3 XAP3 XAP4	Homo sapiens (Human)	510	FUNCTION: E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (PubMed:12629548, PubMed:17449468, PubMed:18711448). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, PubMed:18711448). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:19136968). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:19136968). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:19136968). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:20005846, PubMed:21455181). {ECO:0000269|PubMed:12629548, ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:18711448, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cytoplasmic sequestering of protein [GO:0051220]; defense response to bacterium [GO:0042742]; negative regulation of necroptotic process [GO:0060546]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein linear polyubiquitination [GO:0097039]; protein polyubiquitination [GO:0000209]; T cell receptor signaling pathway [GO:0050852]	cytosol [GO:0005829]; LUBAC complex [GO:0071797]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein sequestering activity [GO:0140311]; transcription coactivator activity [GO:0003713]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; LUBAC complex [GO:0071797]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein sequestering activity [GO:0140311]; transcription coactivator activity [GO:0003713]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]; cytoplasmic sequestering of protein [GO:0051220]; defense response to bacterium [GO:0042742]; negative regulation of necroptotic process [GO:0060546]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein linear polyubiquitination [GO:0097039]; protein polyubiquitination [GO:0000209]; T cell receptor signaling pathway [GO:0050852]	
Q9BYN0	reviewed	SRXN1_HUMAN	Sulfiredoxin-1 (EC 1.8.98.2)	SRXN1 C20orf139 SRX SRX1	Homo sapiens (Human)	137	FUNCTION: Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4 (PubMed:15448164, PubMed:15590625). Does not act on PRDX5 or PRDX6 (PubMed:15448164, PubMed:15590625). May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (PubMed:15448164, PubMed:15590625). {ECO:0000269|PubMed:15448164, ECO:0000269|PubMed:15590625}.		cellular response to oxidative stress [GO:0034599]; response to oxidative stress [GO:0006979]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]	ATP binding [GO:0005524]; oxidoreductase activity, acting on a sulfur group of donors [GO:0016667]; sulfiredoxin activity [GO:0032542]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; ATP binding [GO:0005524]; oxidoreductase activity, acting on a sulfur group of donors [GO:0016667]; sulfiredoxin activity [GO:0032542]; cellular response to oxidative stress [GO:0034599]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15448164}.
Q9BYN7	reviewed	ZN341_HUMAN	Zinc finger protein 341	ZNF341	Homo sapiens (Human)	854	FUNCTION: Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription. {ECO:0000269|PubMed:29907690, ECO:0000269|PubMed:29907691}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29907690, ECO:0000269|PubMed:29907691}.
Q9BYP7	reviewed	WNK3_HUMAN	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3)	WNK3 KIAA1566 PRKWNK3	Homo sapiens (Human)	1800	FUNCTION: Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}.		cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; intracellular signal transduction [GO:0035556]; maintenance of blood-brain barrier [GO:0035633]; monoatomic ion homeostasis [GO:0050801]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein localization to plasma membrane [GO:1903077]; non-membrane-bounded organelle assembly [GO:0140694]; osmosensory signaling pathway [GO:0007231]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein autophosphorylation [GO:0046777]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of calcium ion import [GO:0090279]; regulation of monoatomic cation transmembrane transport [GO:1904062]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]	ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; intracellular signal transduction [GO:0035556]; maintenance of blood-brain barrier [GO:0035633]; monoatomic ion homeostasis [GO:0050801]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein localization to plasma membrane [GO:1903077]; non-membrane-bounded organelle assembly [GO:0140694]; osmosensory signaling pathway [GO:0007231]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein autophosphorylation [GO:0046777]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of calcium ion import [GO:0090279]; regulation of monoatomic cation transmembrane transport [GO:1904062]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16501604}. Note=Mediates formation and localizes to cytoplasmic membraneless compartment in response to hyperosmotic stress. {ECO:0000250|UniProtKB:Q9H4A3}.
Q9BYP8	reviewed	KR171_HUMAN	Keratin-associated protein 17-1 (Keratin-associated protein 16.1)	KRTAP17-1 KAP17.1 KRTAP16.1	Homo sapiens (Human)	105	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q9BYP9	reviewed	KRA99_HUMAN	Keratin-associated protein 9-9 (Keratin-associated protein 9-5) (Keratin-associated protein 9.5) (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9)	KRTAP9-9 KAP9.5 KAP9.9 KRTAP9-5 KRTAP9.5 KRTAP9.9	Homo sapiens (Human)	154	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q9BYQ0	reviewed	KRA98_HUMAN	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8)	KRTAP9-8 KAP9.8 KRTAP9.8	Homo sapiens (Human)	159	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q9BYQ2	reviewed	KRA94_HUMAN	Keratin-associated protein 9-4 (Keratin-associated protein 9.4) (Ultrahigh sulfur keratin-associated protein 9.4)	KRTAP9-4 KAP9.4 KRTAP9.4	Homo sapiens (Human)	154	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q9BYQ3	reviewed	KRA93_HUMAN	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3)	KRTAP9-3 KAP9.3 KRTAP9.3	Homo sapiens (Human)	159	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; keratin filament [GO:0045095]; identical protein binding [GO:0042802]	
Q9BYQ4	reviewed	KRA92_HUMAN	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2)	KRTAP9-2 KAP9.2 KRTAP9.2	Homo sapiens (Human)	174	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; keratin filament [GO:0045095]; identical protein binding [GO:0042802]	
Q9BYQ5	reviewed	KRA46_HUMAN	Keratin-associated protein 4-6 (Keratin-associated protein 4-15) (Keratin-associated protein 4.15) (Keratin-associated protein 4.6) (Ultrahigh sulfur keratin-associated protein 4.15)	KRTAP4-6 KAP4.15 KRTAP4-15 KRTAP4.15 KRTAP4.6	Homo sapiens (Human)	205	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q9BYQ6	reviewed	KR411_HUMAN	Keratin-associated protein 4-11 (Keratin-associated protein 4-14) (Keratin-associated protein 4.11) (Keratin-associated protein 4.14) (Ultrahigh sulfur keratin-associated protein 4.14)	KRTAP4-11 KAP4.14 KRTAP4-14 KRTAP4.11 KRTAP4.14	Homo sapiens (Human)	195	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q9BYQ7	reviewed	KRA41_HUMAN	Keratin-associated protein 4-1 (Keratin-associated protein 4-10) (Keratin-associated protein 4.1) (Keratin-associated protein 4.10) (Ultrahigh sulfur keratin-associated protein 4.10)	KRTAP4-1 KAP4.10 KRTAP4-10 KRTAP4.1 KRTAP4.10	Homo sapiens (Human)	146	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q9BYR0	reviewed	KRA47_HUMAN	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7)	KRTAP4-7 KAP4.7 KRTAP4.7	Homo sapiens (Human)	210	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.		hair cycle [GO:0042633]	cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]; hair cycle [GO:0042633]	
Q9BYR2	reviewed	KRA45_HUMAN	Keratin-associated protein 4-5 (Keratin-associated protein 4.5) (Ultrahigh sulfur keratin-associated protein 4.5)	KRTAP4-5 KAP4.5 KRTAP4.5	Homo sapiens (Human)	181	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.		hair cycle [GO:0042633]	cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]; hair cycle [GO:0042633]	
Q9BYR3	reviewed	KRA44_HUMAN	Keratin-associated protein 4-4 (Keratin-associated protein 4-13) (Keratin-associated protein 4.13) (Keratin-associated protein 4.4) (Ultrahigh sulfur keratin-associated protein 4.13) (Ultrahigh sulfur keratin-associated protein 4.4)	KRTAP4-4 KAP4.13 KAP4.4 KRTAP4-13 KRTAP4.13 KRTAP4.4	Homo sapiens (Human)	166	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q9BYR4	reviewed	KRA43_HUMAN	Keratin-associated protein 4-3 (Keratin-associated protein 4.3) (Ultrahigh sulfur keratin-associated protein 4.3)	KRTAP4-3 KAP4.3 KRTAP4.3	Homo sapiens (Human)	195	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.		hair cycle [GO:0042633]	cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]; hair cycle [GO:0042633]	
Q9BYR5	reviewed	KRA42_HUMAN	Keratin-associated protein 4-2 (Keratin-associated protein 4.2) (Ultrahigh sulfur keratin-associated protein 4.2)	KRTAP4-2 KAP4.2 KRTAP4.2	Homo sapiens (Human)	136	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; keratin filament [GO:0045095]; identical protein binding [GO:0042802]	
Q9BYR6	reviewed	KRA33_HUMAN	Keratin-associated protein 3-3 (High sulfur keratin-associated protein 3.3) (Keratin-associated protein 3.3)	KRTAP3-3 KAP3.3 KRTAP3.3	Homo sapiens (Human)	98	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; keratin filament [GO:0045095]; structural molecule activity [GO:0005198]	
Q9BYR7	reviewed	KRA32_HUMAN	Keratin-associated protein 3-2 (High sulfur keratin-associated protein 3.2) (Keratin-associated protein 3.2)	KRTAP3-2 KAP3.2 KRTAP3.2	Homo sapiens (Human)	98	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; keratin filament [GO:0045095]; structural molecule activity [GO:0005198]	
Q9BYR8	reviewed	KRA31_HUMAN	Keratin-associated protein 3-1 (High sulfur keratin-associated protein 3.1) (Keratin-associated protein 3.1)	KRTAP3-1 KAP3.1 KRTAP3.1	Homo sapiens (Human)	98	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; keratin filament [GO:0045095]; structural molecule activity [GO:0005198]	
Q9BYR9	reviewed	KRA24_HUMAN	Keratin-associated protein 2-4 (High sulfur keratin-associated protein 2.4) (Keratin-associated protein 2.4)	KRTAP2-4 KAP2.4 KRTAP2.4	Homo sapiens (Human)	128	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q9BYS1	reviewed	KRA15_HUMAN	Keratin-associated protein 1-5 (High sulfur keratin-associated protein 1.5) (Keratin-associated protein 1.5)	KRTAP1-5 KAP1.5 KRTAP1.5	Homo sapiens (Human)	174	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q9BYT1	reviewed	S17A9_HUMAN	Voltage-gated purine nucleotide uniporter SLC17A9 (Solute carrier family 17 member 9) (Vesicular nucleotide transporter) (VNUT)	SLC17A9 C20orf59	Homo sapiens (Human)	436	FUNCTION: Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles (PubMed:18375752, PubMed:23467297). By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles (PubMed:35269509). Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chromaffin granules, mucin granules and synaptic vesicles (PubMed:18375752, PubMed:23467297). {ECO:0000269|PubMed:18375752, ECO:0000269|PubMed:23467297, ECO:0000269|PubMed:35269509}.		ADP transport [GO:0015866]; ATP export [GO:1904669]; ATP transport [GO:0015867]; guanine nucleotide transmembrane transport [GO:1903790]; lysosomal protein catabolic process [GO:1905146]; purine nucleotide import into lysosome [GO:0141013]	chromaffin granule membrane [GO:0042584]; lysosomal membrane [GO:0005765]; mucin granule [GO:0098594]; transport vesicle membrane [GO:0030658]	ADP transmembrane transporter activity [GO:0015217]; ATP transmembrane transporter activity [GO:0005347]; guanine nucleotide transmembrane transporter activity [GO:0001409]; purine nucleotide uniporter activity [GO:0160042]	chromaffin granule membrane [GO:0042584]; lysosomal membrane [GO:0005765]; mucin granule [GO:0098594]; transport vesicle membrane [GO:0030658]; ADP transmembrane transporter activity [GO:0015217]; ATP transmembrane transporter activity [GO:0005347]; guanine nucleotide transmembrane transporter activity [GO:0001409]; purine nucleotide uniporter activity [GO:0160042]; ADP transport [GO:0015866]; ATP export [GO:1904669]; ATP transport [GO:0015867]; guanine nucleotide transmembrane transport [GO:1903790]; lysosomal protein catabolic process [GO:1905146]; purine nucleotide import into lysosome [GO:0141013]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:Q8VCL5}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:23467297}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8VCL5}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to mucin granules and vesicles. {ECO:0000269|PubMed:23467297}.
Q9BYT3	reviewed	STK33_HUMAN	Serine/threonine-protein kinase 33 (EC 2.7.11.1)	STK33	Homo sapiens (Human)	514	FUNCTION: Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines. {ECO:0000250, ECO:0000269|PubMed:21742770}.		mitotic DNA damage checkpoint signaling [GO:0044773]; protein autophosphorylation [GO:0046777]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; mitotic DNA damage checkpoint signaling [GO:0044773]; protein autophosphorylation [GO:0046777]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
Q9BYT8	reviewed	NEUL_HUMAN	Neurolysin, mitochondrial (EC 3.4.24.16) (Angiotensin-binding protein) (Microsomal endopeptidase) (MEP) (Mitochondrial oligopeptidase M) (Neurotensin endopeptidase)	NLN AGTBP KIAA1226	Homo sapiens (Human)	704	FUNCTION: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P42676}.		G protein-coupled receptor signaling pathway [GO:0007186]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]; regulation of gluconeogenesis [GO:0006111]; regulation of skeletal muscle fiber differentiation [GO:1902809]	cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrial intermembrane space [GO:0005758]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptide binding [GO:0042277]	cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrial intermembrane space [GO:0005758]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptide binding [GO:0042277]; G protein-coupled receptor signaling pathway [GO:0007186]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]; regulation of gluconeogenesis [GO:0006111]; regulation of skeletal muscle fiber differentiation [GO:1902809]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P42676}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P42676}.
Q9BYT9	reviewed	ANO3_HUMAN	Anoctamin-3 (Transmembrane protein 16C)	ANO3 C11orf25 TMEM16C GENX-3947	Homo sapiens (Human)	981	FUNCTION: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:21984732). {ECO:0000250|UniProtKB:A2AHL1, ECO:0000303|PubMed:21984732}.	MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.	calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; chloride transmembrane transport [GO:1902476]; detection of mechanical stimulus [GO:0050982]; detection of temperature stimulus [GO:0016048]; establishment of localization in cell [GO:0051649]; monoatomic ion transmembrane transport [GO:0034220]	plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983]	plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983]; calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; chloride transmembrane transport [GO:1902476]; detection of mechanical stimulus [GO:0050982]; detection of temperature stimulus [GO:0016048]; establishment of localization in cell [GO:0051649]; monoatomic ion transmembrane transport [GO:0034220]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Shows an intracellular localization. {ECO:0000250}.
Q9BYU1	reviewed	PBX4_HUMAN	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	PBX4	Homo sapiens (Human)	374			animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]; XY body [GO:0001741]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; XY body [GO:0001741]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q9BYV1	reviewed	AGT2_HUMAN	Alanine--glyoxylate aminotransferase 2, mitochondrial (AGT 2) (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (EC 2.6.1.40) (Beta-ALAAT II) (Beta-alanine-pyruvate aminotransferase) (D-AIBAT)	AGXT2 AGT2	Homo sapiens (Human)	514	FUNCTION: Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure. {ECO:0000269|PubMed:20018850, ECO:0000269|PubMed:23023372, ECO:0000269|PubMed:24586340}.		glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; L-alanine catabolic process, by transamination [GO:0019481]; positive regulation of nitric oxide biosynthetic process [GO:0045429]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity [GO:0047305]; alanine-glyoxylate transaminase activity [GO:0008453]; pyridoxal phosphate binding [GO:0030170]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; (R)-3-amino-2-methylpropionate-pyruvate transaminase activity [GO:0047305]; alanine-glyoxylate transaminase activity [GO:0008453]; pyridoxal phosphate binding [GO:0030170]; glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; L-alanine catabolic process, by transamination [GO:0019481]; positive regulation of nitric oxide biosynthetic process [GO:0045429]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20018850, ECO:0000269|PubMed:24586340}.
Q9BYV2	reviewed	TRI54_HUMAN	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30)	TRIM54 MURF MURF3 RNF30	Homo sapiens (Human)	358	FUNCTION: May bind and stabilize microtubules during myotubes formation. {ECO:0000250}.		cell differentiation [GO:0030154]; microtubule-based process [GO:0007017]; negative regulation of microtubule depolymerization [GO:0007026]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; Z disc [GO:0030018]	microtubule binding [GO:0008017]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; Z disc [GO:0030018]; microtubule binding [GO:0008017]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; microtubule-based process [GO:0007017]; negative regulation of microtubule depolymerization [GO:0007026]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity). {ECO:0000250}.
Q9BYV6	reviewed	TRI55_HUMAN	Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF-2) (MuRF2) (RING finger protein 29)	TRIM55 MURF2 RNF29	Homo sapiens (Human)	548	FUNCTION: May regulate gene expression and protein turnover in muscle cells. {ECO:0000250}.		diapedesis [GO:0050904]; leukocyte migration involved in inflammatory response [GO:0002523]; macrophage migration [GO:1905517]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; diapedesis [GO:0050904]; leukocyte migration involved in inflammatory response [GO:0002523]; macrophage migration [GO:1905517]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules (By similarity). {ECO:0000250}.
Q9BYV7	reviewed	BCDO2_HUMAN	Carotenoid-cleaving dioxygenase, mitochondrial (EC 1.13.11.-) (EC 1.13.11.71) (B-diox-II) (Beta,beta-carotene 9',10'-oxygenase) (Beta-carotene dioxygenase 2)	BCO2 BCDO2	Homo sapiens (Human)	579	FUNCTION: Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules. {ECO:0000250|UniProtKB:Q99NF1}.		carotene catabolic process [GO:0016121]; carotene metabolic process [GO:0016119]; carotenoid metabolic process [GO:0016116]; lutein catabolic process [GO:0062172]; lycopene catabolic process [GO:1901176]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377]; retinal metabolic process [GO:0042574]; retinoic acid metabolic process [GO:0042573]; xanthophyll catabolic process [GO:0016124]; zeaxanthin catabolic process [GO:1901826]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	9,10 (9', 10')-carotenoid-cleaving dioxygenase activity [GO:0010437]; beta,beta-carotene-9',10'-cleaving oxygenase activity [GO:0102076]; beta-carotene 15,15'-dioxygenase activity [GO:0003834]; carotenoid dioxygenase activity [GO:0010436]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity [GO:0010437]; beta,beta-carotene-9',10'-cleaving oxygenase activity [GO:0102076]; beta-carotene 15,15'-dioxygenase activity [GO:0003834]; carotenoid dioxygenase activity [GO:0010436]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; carotene catabolic process [GO:0016121]; carotene metabolic process [GO:0016119]; carotenoid metabolic process [GO:0016116]; lutein catabolic process [GO:0062172]; lycopene catabolic process [GO:1901176]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377]; retinal metabolic process [GO:0042574]; retinoic acid metabolic process [GO:0042573]; xanthophyll catabolic process [GO:0016124]; zeaxanthin catabolic process [GO:1901826]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q99NF1}.
Q9BYV8	reviewed	CEP41_HUMAN	Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein)	CEP41 TSGA14	Homo sapiens (Human)	373	FUNCTION: Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. {ECO:0000269|PubMed:22246503}.		cilium assembly [GO:0060271]; protein polyglutamylation [GO:0018095]; protein transport [GO:0015031]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; membrane [GO:0016020]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; membrane [GO:0016020]; cilium assembly [GO:0060271]; protein polyglutamylation [GO:0018095]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes mainly to the cilium basal body and in primary cilia.
Q9BYV9	reviewed	BACH2_HUMAN	Transcription regulator protein BACH2 (BTB and CNC homolog 2)	BACH2	Homo sapiens (Human)	841	FUNCTION: Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}.		import into nucleus [GO:0051170]; negative regulation of transcription by RNA polymerase II [GO:0000122]; primary adaptive immune response involving T cells and B cells [GO:0090721]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; import into nucleus [GO:0051170]; negative regulation of transcription by RNA polymerase II [GO:0000122]; primary adaptive immune response involving T cells and B cells [GO:0090721]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation. {ECO:0000269|PubMed:17018862}.
Q9BYW1	reviewed	GTR11_HUMAN	Solute carrier family 2, facilitated glucose transporter member 11 (Glucose transporter type 11) (GLUT-11)	SLC2A11 GLUT11	Homo sapiens (Human)	496	FUNCTION: Facilitative glucose transporter. {ECO:0000269|PubMed:12175779}.		fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; monosaccharide transmembrane transport [GO:0015749]	cell junction [GO:0030054]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	fructose transmembrane transporter activity [GO:0005353]; glucose transmembrane transporter activity [GO:0005355]; hexose transmembrane transporter activity [GO:0015149]; sugar transmembrane transporter activity [GO:0051119]	cell junction [GO:0030054]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; fructose transmembrane transporter activity [GO:0005353]; glucose transmembrane transporter activity [GO:0005355]; hexose transmembrane transporter activity [GO:0015149]; sugar transmembrane transporter activity [GO:0051119]; fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; monosaccharide transmembrane transport [GO:0015749]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12175779}; Multi-pass membrane protein {ECO:0000255}.
Q9BYW2	reviewed	SETD2_HUMAN	Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)	SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069	Homo sapiens (Human)	2564	FUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.		angiogenesis [GO:0001525]; cell migration involved in vasculogenesis [GO:0035441]; coronary vasculature morphogenesis [GO:0060977]; defense response to virus [GO:0051607]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic placenta morphogenesis [GO:0060669]; endodermal cell differentiation [GO:0035987]; forebrain development [GO:0030900]; histone H3-K36 dimethylation [GO:0097676]; histone H3-K36 trimethylation [GO:0097198]; mesoderm morphogenesis [GO:0048332]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mismatch repair [GO:0006298]; morphogenesis of a branching structure [GO:0001763]; neural tube closure [GO:0001843]; nucleosome organization [GO:0034728]; peptidyl-lysine trimethylation [GO:0018023]; pericardium development [GO:0060039]; positive regulation of autophagy [GO:0010508]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of ossification [GO:0045778]; regulation of cytokinesis [GO:0032465]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of gene expression [GO:0010468]; regulation of mRNA export from nucleus [GO:0010793]; regulation of protein localization to chromatin [GO:1905634]; response to alkaloid [GO:0043279]; response to metal ion [GO:0010038]; response to organic cyclic compound [GO:0014070]; response to type I interferon [GO:0034340]; stem cell development [GO:0048864]; stem cell differentiation [GO:0048863]; transcription elongation by RNA polymerase II [GO:0006368]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	alpha-tubulin binding [GO:0043014]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; metal ion binding [GO:0046872]; protein-lysine N-methyltransferase activity [GO:0016279]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; alpha-tubulin binding [GO:0043014]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; metal ion binding [GO:0046872]; protein-lysine N-methyltransferase activity [GO:0016279]; angiogenesis [GO:0001525]; cell migration involved in vasculogenesis [GO:0035441]; coronary vasculature morphogenesis [GO:0060977]; defense response to virus [GO:0051607]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic placenta morphogenesis [GO:0060669]; endodermal cell differentiation [GO:0035987]; forebrain development [GO:0030900]; histone H3-K36 dimethylation [GO:0097676]; histone H3-K36 trimethylation [GO:0097198]; mesoderm morphogenesis [GO:0048332]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mismatch repair [GO:0006298]; morphogenesis of a branching structure [GO:0001763]; neural tube closure [GO:0001843]; nucleosome organization [GO:0034728]; peptidyl-lysine trimethylation [GO:0018023]; pericardium development [GO:0060039]; positive regulation of autophagy [GO:0010508]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of ossification [GO:0045778]; regulation of cytokinesis [GO:0032465]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of gene expression [GO:0010468]; regulation of mRNA export from nucleus [GO:0010793]; regulation of protein localization to chromatin [GO:1905634]; response to alkaloid [GO:0043279]; response to metal ion [GO:0010038]; response to organic cyclic compound [GO:0014070]; response to type I interferon [GO:0034340]; stem cell development [GO:0048864]; stem cell differentiation [GO:0048863]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:E9Q5F9}. Chromosome {ECO:0000250|UniProtKB:E9Q5F9}.
Q9BYW3	reviewed	DB126_HUMAN	Beta-defensin 126 (Beta-defensin 26) (DEFB-26) (Defensin, beta 126) (Epididymal secretory protein 13.2) (ESP13.2) (HBD26)	DEFB126 C20orf8 DEFB26	Homo sapiens (Human)	111	FUNCTION: Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte (By similarity). In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation (PubMed:19373462, PubMed:23229569). {ECO:0000250|UniProtKB:Q9BEE3, ECO:0000269|PubMed:19373462, ECO:0000269|PubMed:23229569}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; single fertilization [GO:0007338]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Note=Secreted by epididymal cells and is absorbed to the surface of sperm during transit through the epididymis (By similarity). Mainly located on the sperm acrosome. {ECO:0000250|UniProtKB:Q9BEE3, ECO:0000269|PubMed:26832966}.
Q9BYX2	reviewed	TBD2A_HUMAN	TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1)	TBC1D2 PARIS1 PP8997 TBC1D2A	Homo sapiens (Human)	928	FUNCTION: Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269|PubMed:20116244}.	MISCELLANEOUS: 'Armus' means hinge, linker in Latin and ancient Greek.	positive regulation of GTPase activity [GO:0043547]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; positive regulation of GTPase activity [GO:0043547]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20116244}. Cytoplasmic vesicle {ECO:0000269|PubMed:20116244}. Cell junction {ECO:0000269|PubMed:20116244}.
Q9BYX4	reviewed	IFIH1_HUMAN	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)	IFIH1 MDA5 RH116	Homo sapiens (Human)	1025	FUNCTION: Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines (PubMed:32169843, PubMed:33727702, PubMed:28594402). Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length) (PubMed:22160685). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and rhinovirus (PubMed:28606988). Detects coronavirus SARS-CoV-2 (PubMed:33440148, PubMed:33514628). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. {ECO:0000269|PubMed:14645903, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19656871, ECO:0000269|PubMed:21217758, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:22160685, ECO:0000269|PubMed:28594402, ECO:0000269|PubMed:28606988, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:33514628, ECO:0000269|PubMed:33727702}.	MISCELLANEOUS: In HIV-1 infected HeLa-CD4 cells, overexpression of IFIH1 results in a great increase in the level of secreted viral p24 protein.	antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to virus [GO:0098586]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; negative regulation of viral genome replication [GO:0045071]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of tumor necrosis factor production [GO:0032760]; protein complex oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; regulation of type III interferon production [GO:0034344]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	adenyl ribonucleotide binding [GO:0032559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; purine ribonucleoside triphosphate binding [GO:0035639]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; adenyl ribonucleotide binding [GO:0032559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; purine ribonucleoside triphosphate binding [GO:0035639]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]; antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to virus [GO:0098586]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; negative regulation of viral genome replication [GO:0045071]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of tumor necrosis factor production [GO:0032760]; protein complex oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; regulation of type III interferon production [GO:0034344]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11805321, ECO:0000269|PubMed:14645903, ECO:0000269|PubMed:32169843, ECO:0000269|PubMed:33727702}. Nucleus {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:33727702}. Note=Upon viral RNA stimulation and ISGylation, translocates from cytosol to mitochondrion. May be found in the nucleus, during apoptosis.
Q9BYX7	reviewed	ACTBM_HUMAN	Putative beta-actin-like protein 3 (Kappa-actin) (POTE ankyrin domain family member K)	POTEKP ACTBL3 FKSG30	Homo sapiens (Human)	375			axonogenesis [GO:0007409]; cell motility [GO:0048870]	actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202]	ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]	actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202]; ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; axonogenesis [GO:0007409]; cell motility [GO:0048870]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q9BYZ2	reviewed	LDH6B_HUMAN	L-lactate dehydrogenase A-like 6B (EC 1.1.1.27)	LDHAL6B LDHAL6 LDHL	Homo sapiens (Human)	381			lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204]	L-lactate dehydrogenase activity [GO:0004459]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204]; L-lactate dehydrogenase activity [GO:0004459]; lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090]	
Q9BYZ6	reviewed	RHBT2_HUMAN	Rho-related BTB domain-containing protein 2 (Deleted in breast cancer 2 gene protein) (p83)	RHOBTB2 DBC2 KIAA0717	Homo sapiens (Human)	727			actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]	endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]	endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]	
Q9BYZ8	reviewed	REG4_HUMAN	Regenerating islet-derived protein 4 (REG-4) (Gastrointestinal secretory protein) (REG-like protein) (Regenerating islet-derived protein IV) (Reg IV)	REG4 GISP RELP	Homo sapiens (Human)	158	FUNCTION: Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. {ECO:0000269|PubMed:12819006, ECO:0000269|PubMed:20692269}.		response to bacterium [GO:0009617]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	heparin binding [GO:0008201]; mannan binding [GO:2001065]; signaling receptor activity [GO:0038023]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; heparin binding [GO:0008201]; mannan binding [GO:2001065]; signaling receptor activity [GO:0038023]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12819006}.
Q9BZ11	reviewed	ADA33_HUMAN	Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33) (EC 3.4.24.-)	ADAM33 C20orf153 UNQ873/PRO1891	Homo sapiens (Human)	813		MISCELLANEOUS: [Isoform 3]: By similarity with mouse isoform. {ECO:0000305}.	proteolysis [GO:0006508]	membrane [GO:0016020]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	membrane [GO:0016020]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9BZ23	reviewed	PANK2_HUMAN	Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)]	PANK2 C20orf48	Homo sapiens (Human)	570	FUNCTION: [Isoform 1]: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:15659606, PubMed:17825826, PubMed:17242360, PubMed:16272150). Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC) (PubMed:30221726). {ECO:0000269|PubMed:15659606, ECO:0000269|PubMed:16272150, ECO:0000269|PubMed:17242360, ECO:0000269|PubMed:17825826, ECO:0000269|PubMed:30221726}.; FUNCTION: [Isoform 4]: Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:16272150}.	MISCELLANEOUS: The HSS syndrome has been proposed to be renamed because of the unethical activities of Julius Hallervorden and Hugo Spatz during world war II.; MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at Met-124 of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced by alternative initiation at Leu-111 of isoform 1. {ECO:0000305}.	aerobic respiration [GO:0009060]; angiogenesis [GO:0001525]; coenzyme A biosynthetic process [GO:0015937]; mitochondrion morphogenesis [GO:0070584]; pantothenate metabolic process [GO:0015939]; phosphorylation [GO:0016310]; regulation of bile acid metabolic process [GO:1904251]; regulation of fatty acid metabolic process [GO:0019217]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of triglyceride metabolic process [GO:0090207]; spermatid development [GO:0007286]	cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]	cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]; aerobic respiration [GO:0009060]; angiogenesis [GO:0001525]; coenzyme A biosynthetic process [GO:0015937]; mitochondrion morphogenesis [GO:0070584]; pantothenate metabolic process [GO:0015939]; phosphorylation [GO:0016310]; regulation of bile acid metabolic process [GO:1904251]; regulation of fatty acid metabolic process [GO:0019217]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of triglyceride metabolic process [GO:0090207]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:12554685, ECO:0000269|PubMed:15659606, ECO:0000269|PubMed:17825826}. Mitochondrion intermembrane space {ECO:0000269|PubMed:23152917}. Nucleus {ECO:0000269|PubMed:23152917}. Note=Localizes predominantly to the mitochondria and to a lesser extent to the nucleus. Found in both the mitochondria and the nucleus throughout the cell cycle, with the exception of the G2/M phase when it is restricted to mitochdondria. {ECO:0000269|PubMed:23152917}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:12554685, ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.
Q9BZ29	reviewed	DOCK9_HUMAN	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1)	DOCK9 KIAA1058 ZIZ1	Homo sapiens (Human)	2069	FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}.	MISCELLANEOUS: 'Zizim' means 'spike' in Hebrew. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by exon skipping that results in a frameshift. {ECO:0000305}.	positive regulation of GTPase activity [GO:0043547]; small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]	cadherin binding [GO:0045296]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; cadherin binding [GO:0045296]; guanyl-nucleotide exchange factor activity [GO:0005085]; positive regulation of GTPase activity [GO:0043547]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305}. Note=Associated with membranes. {ECO:0000305}.
Q9BZ67	reviewed	FRMD8_HUMAN	FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP)	FRMD8 FKSG44	Homo sapiens (Human)	464	FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of tumor necrosis factor production [GO:0032760]; protein localization to plasma membrane [GO:0072659]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of tumor necrosis factor production [GO:0032760]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333}. Cell membrane {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333}.
Q9BZ71	reviewed	PITM3_HUMAN	Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1)	PITPNM3 NIR1	Homo sapiens (Human)	974	FUNCTION: Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	phosphatidylinositol biosynthetic process [GO:0006661]	cell body [GO:0044297]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; lipid binding [GO:0008289]; phosphatidylinositol transfer activity [GO:0008526]; phospholipase activity [GO:0004620]; receptor tyrosine kinase binding [GO:0030971]	cell body [GO:0044297]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289]; phosphatidylinositol transfer activity [GO:0008526]; phospholipase activity [GO:0004620]; receptor tyrosine kinase binding [GO:0030971]; phosphatidylinositol biosynthetic process [GO:0006661]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Q9BZ72	reviewed	PITM2_HUMAN	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)	PITPNM2 KIAA1457 NIR3	Homo sapiens (Human)	1349	FUNCTION: Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}.		phosphatidylinositol biosynthetic process [GO:0006661]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; receptor tyrosine kinase binding [GO:0030971]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; receptor tyrosine kinase binding [GO:0030971]; phosphatidylinositol biosynthetic process [GO:0006661]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:22361696}; Peripheral membrane protein {ECO:0000269|PubMed:22361696}.
Q9BZ95	reviewed	NSD3_HUMAN	Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)	NSD3 WHSC1L1 DC28	Homo sapiens (Human)	1437	FUNCTION: Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}.		methylation [GO:0032259]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone H3 methyltransferase activity [GO:0140938]; histone H3K27 dimethyltransferase activity [GO:0140952]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 dimethyltransferase activity [GO:0140946]; metal ion binding [GO:0046872]; transcription regulator activator activity [GO:0140537]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone H3 methyltransferase activity [GO:0140938]; histone H3K27 dimethyltransferase activity [GO:0140952]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 dimethyltransferase activity [GO:0140946]; metal ion binding [GO:0046872]; transcription regulator activator activity [GO:0140537]; methylation [GO:0032259]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Q9BZA7	reviewed	PC11X_HUMAN	Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S)	PCDH11X KIAA1326 PCDH11 PCDHX	Homo sapiens (Human)	1347	FUNCTION: Potential calcium-dependent cell-adhesion protein.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9BZA8	reviewed	PC11Y_HUMAN	Protocadherin-11 Y-linked (Protocadherin-11) (Protocadherin on the Y chromosome) (PCDH-Y) (Protocadherin prostate cancer) (Protocadherin-PC) (Protocadherin-22)	PCDH11Y PCDH11 PCDH22 PCDHY	Homo sapiens (Human)	1340	FUNCTION: Potential calcium-dependent cell-adhesion protein.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of Wnt signaling pathway [GO:0030177]; spermatogenesis [GO:0007283]	plasma membrane [GO:0005886]; sperm head [GO:0061827]; sperm midpiece [GO:0097225]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; sperm head [GO:0061827]; sperm midpiece [GO:0097225]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of Wnt signaling pathway [GO:0030177]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9BZB8	reviewed	CPEB1_HUMAN	Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1)	CPEB1 CPEB	Homo sapiens (Human)	566	FUNCTION: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195). {ECO:0000250|UniProtKB:P70166, ECO:0000269|PubMed:15731006, ECO:0000269|PubMed:15966895, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195}.		cellular response to amino acid stimulus [GO:0071230]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; mRNA processing [GO:0006397]; negative regulation of cytoplasmic translation [GO:2000766]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; messenger ribonucleoprotein complex [GO:1990124]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosome binding [GO:0043022]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; messenger ribonucleoprotein complex [GO:1990124]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; postsynaptic density [GO:0014069]; synapse [GO:0045202]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosome binding [GO:0043022]; translation factor activity, RNA binding [GO:0008135]; cellular response to amino acid stimulus [GO:0071230]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; mRNA processing [GO:0006397]; negative regulation of cytoplasmic translation [GO:2000766]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18923137, ECO:0000269|PubMed:28383716}. Nucleus {ECO:0000269|PubMed:18923137}. Cytoplasm, P-body. Cytoplasmic granule. Synapse. Membrane. Postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Continuously shuttling between nucleus and cytoplasm (PubMed:18923137). Also found in stress granules. Recruited to stress granules (SGs) upon arsenite treatment. In dendrites (By similarity). Localizes in synaptosomes at dendritic synapses of neurons (By similarity). Strongly enriched in postsynaptic density (PSD) fractions (By similarity). Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin (By similarity). Membrane-associated (By similarity). Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs (By similarity). {ECO:0000250, ECO:0000269|PubMed:18923137}.
Q9BZC1	reviewed	CELF4_HUMAN	CUGBP Elav-like family member 4 (CELF-4) (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4)	CELF4 BRUNOL4	Homo sapiens (Human)	486	FUNCTION: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:14973222, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15894795}.		alternative mRNA splicing, via spliceosome [GO:0000380]; embryo development ending in birth or egg hatching [GO:0009792]; excitatory postsynaptic potential [GO:0060079]; germ cell development [GO:0007281]; in utero embryonic development [GO:0001701]; mRNA splice site recognition [GO:0006376]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of retina development in camera-type eye [GO:1902866]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; ribonucleoprotein complex [GO:1990904]	BRE binding [GO:0042835]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; pre-mRNA binding [GO:0036002]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; ribonucleoprotein complex [GO:1990904]; BRE binding [GO:0042835]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; pre-mRNA binding [GO:0036002]; alternative mRNA splicing, via spliceosome [GO:0000380]; embryo development ending in birth or egg hatching [GO:0009792]; excitatory postsynaptic potential [GO:0060079]; germ cell development [GO:0007281]; in utero embryonic development [GO:0001701]; mRNA splice site recognition [GO:0006376]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of retina development in camera-type eye [GO:1902866]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14973222}. Cytoplasm {ECO:0000269|PubMed:14973222}.
Q9BZC7	reviewed	ABCA2_HUMAN	ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2)	ABCA2 ABC2 KIAA1062	Homo sapiens (Human)	2435	FUNCTION: Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed:15238223, PubMed:21810484, PubMed:24201375) (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}.		central nervous system myelin formation [GO:0032289]; ceramide translocation [GO:0099040]; cholesterol homeostasis [GO:0042632]; ganglioside metabolic process [GO:0001573]; glycosphingolipid metabolic process [GO:0006687]; intracellular sphingolipid homeostasis [GO:0090156]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; locomotory behavior [GO:0007626]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of intracellular cholesterol transport [GO:0032384]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of phospholipid biosynthetic process [GO:0071072]; negative regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905601]; negative regulation of sphingolipid biosynthetic process [GO:0090155]; negative regulation of steroid metabolic process [GO:0045939]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805]; regulation of intracellular cholesterol transport [GO:0032383]; regulation of post-translational protein modification [GO:1901873]; regulation of protein glycosylation [GO:0060049]; regulation of protein localization to cell periphery [GO:1904375]; regulation of protein localization to cell surface [GO:2000008]; regulation of steroid metabolic process [GO:0019218]; response to cholesterol [GO:0070723]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]; sphingomyelin metabolic process [GO:0006684]; sphingosine biosynthetic process [GO:0046512]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	ATP-binding cassette (ABC) transporter complex [GO:0043190]; cytoplasmic vesicle [GO:0031410]; endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ceramide floppase activity [GO:0099038]; endopeptidase regulator activity [GO:0061135]; lipid transporter activity [GO:0005319]; nucleotide binding [GO:0000166]	ATP-binding cassette (ABC) transporter complex [GO:0043190]; cytoplasmic vesicle [GO:0031410]; endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ceramide floppase activity [GO:0099038]; endopeptidase regulator activity [GO:0061135]; lipid transporter activity [GO:0005319]; nucleotide binding [GO:0000166]; central nervous system myelin formation [GO:0032289]; ceramide translocation [GO:0099040]; cholesterol homeostasis [GO:0042632]; ganglioside metabolic process [GO:0001573]; glycosphingolipid metabolic process [GO:0006687]; intracellular sphingolipid homeostasis [GO:0090156]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; locomotory behavior [GO:0007626]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of intracellular cholesterol transport [GO:0032384]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of phospholipid biosynthetic process [GO:0071072]; negative regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905601]; negative regulation of sphingolipid biosynthetic process [GO:0090155]; negative regulation of steroid metabolic process [GO:0045939]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805]; regulation of intracellular cholesterol transport [GO:0032383]; regulation of post-translational protein modification [GO:1901873]; regulation of protein glycosylation [GO:0060049]; regulation of protein localization to cell periphery [GO:1904375]; regulation of protein localization to cell surface [GO:2000008]; regulation of steroid metabolic process [GO:0019218]; response to cholesterol [GO:0070723]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]; sphingomyelin metabolic process [GO:0006684]; sphingosine biosynthetic process [GO:0046512]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:11309290, ECO:0000269|PubMed:15093135}; Multi-pass membrane protein {ECO:0000269|PubMed:11309290}. Lysosome membrane {ECO:0000269|PubMed:11309290, ECO:0000269|PubMed:15093135}; Multi-pass membrane protein {ECO:0000269|PubMed:11309290}. Note=Forms discrete, punctate intracellular vesicles. {ECO:0000269|PubMed:11309290}.
Q9BZD2	reviewed	S29A3_HUMAN	Equilibrative nucleoside transporter 3 (hENT3) (Solute carrier family 29 member 3)	SLC29A3 ENT3 UNQ717/PRO1380	Homo sapiens (Human)	475	FUNCTION: Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes (PubMed:15701636, PubMed:19164483, PubMed:20595384, PubMed:28729424). Functions as a non-electrogenic Na(+)-independent transporter (PubMed:15701636, PubMed:19164483, PubMed:28729424). Substrate transport is pH-dependent and enhanced under acidic condition, probably reflecting the location of the transporter in acidic intracellular compartments (PubMed:15701636, PubMed:19164483, PubMed:28729424). Proton is not a cotransporting ion but most likely change the ionization state of the transporter which dictates transport-permissible/impermissible conformation for nucleoside translocation (PubMed:28729424). May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate the fundamental function of salvage synthesis of nucleic acids (PubMed:28729424). Involved in the transport of nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine) and deoxynucleosides (deoxyadenosine, deoxycytidine) (PubMed:15701636, PubMed:19164483, PubMed:20595384, PubMed:28729424). Also mediates transport of purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil) (PubMed:15701636, PubMed:19164483). Also able to transport monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine (PubMed:19164483). Capable of transporting ATP (PubMed:19164483). Mediates nucleoside export from lysosomes in macrophages, which regulates macrophage functions and numbers (By similarity). {ECO:0000250|UniProtKB:Q99P65, ECO:0000269|PubMed:15701636, ECO:0000269|PubMed:19164483, ECO:0000269|PubMed:20595384, ECO:0000269|PubMed:28729424}.	MISCELLANEOUS: Transports nucleoside analog drugs such as cladribine, cordycepin, tubercidin and idovudine (PubMed:15701636, PubMed:19164483). Also involved in the uptake of diabetes treatment medicine metformin, neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)), and ribavirin (PubMed:19164483). Transport activity is insensitive to nanomolar concentrations of the inhibitors nitrobenzylmercaptopurine riboside, dipyridamole and dilazep, and inhibited by higher concentrations (PubMed:15701636). Does not transport hypoxanthine (PubMed:15701636, PubMed:19164483). A truncated version of SLC29A3/hENT3 in which the N-terminal 36 amino acids are deleted, enables cell-surface localization of an otherwise intracellular transporter, and is utilized to investigate the transporter activity (PubMed:15701636, PubMed:19164483, PubMed:20595384, PubMed:28729424). {ECO:0000269|PubMed:15701636, ECO:0000269|PubMed:19164483, ECO:0000269|PubMed:20595384, ECO:0000269|PubMed:28729424}.	adenosine transport [GO:0032238]; cytidine transport [GO:0015861]; dopamine transport [GO:0015872]; guanine transmembrane transport [GO:1903716]; inosine transport [GO:0035340]; norepinephrine transport [GO:0015874]; nucleobase transport [GO:0015851]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]; purine nucleobase transmembrane transport [GO:1904823]; pyrimidine nucleobase transmembrane transport [GO:1904082]; serotonin transport [GO:0006837]; uracil transmembrane transport [GO:1903791]; uridine transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]	Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]	cytidine transmembrane transporter activity [GO:0015212]; guanine transmembrane transporter activity [GO:0015208]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleobase transmembrane transporter activity [GO:0015205]; nucleoside transmembrane transporter activity [GO:0005337]; organic cation transmembrane transporter activity [GO:0015101]; uracil transmembrane transporter activity [GO:0015210]; uridine transmembrane transporter activity [GO:0015213]	Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; cytidine transmembrane transporter activity [GO:0015212]; guanine transmembrane transporter activity [GO:0015208]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleobase transmembrane transporter activity [GO:0015205]; nucleoside transmembrane transporter activity [GO:0005337]; organic cation transmembrane transporter activity [GO:0015101]; uracil transmembrane transporter activity [GO:0015210]; uridine transmembrane transporter activity [GO:0015213]; adenosine transport [GO:0032238]; cytidine transport [GO:0015861]; dopamine transport [GO:0015872]; guanine transmembrane transport [GO:1903716]; inosine transport [GO:0035340]; norepinephrine transport [GO:0015874]; nucleobase transport [GO:0015851]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]; purine nucleobase transmembrane transport [GO:1904823]; pyrimidine nucleobase transmembrane transport [GO:1904082]; serotonin transport [GO:0006837]; uracil transmembrane transport [GO:1903791]; uridine transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:15701636, ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:15701636}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000269|PubMed:19164483}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:19164483}; Multi-pass membrane protein {ECO:0000305}. Note=Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes (PubMed:15701636). Detected at the cell surface only in certain placental cells (PubMed:19164483). {ECO:0000269|PubMed:15701636, ECO:0000269|PubMed:19164483}.
Q9BZD4	reviewed	NUF2_HUMAN	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1)	NUF2 CDCA1 NUF2R	Homo sapiens (Human)	464	FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:12438418, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23085020}.		attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore organization [GO:0051383]; meiotic chromosome segregation [GO:0045132]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; Ndc80 complex [GO:0031262]; nucleoplasm [GO:0005654]	protein-containing complex binding [GO:0044877]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; Ndc80 complex [GO:0031262]; nucleoplasm [GO:0005654]; protein-containing complex binding [GO:0044877]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore organization [GO:0051383]; meiotic chromosome segregation [GO:0045132]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.
Q9BZD6	reviewed	TMG4_HUMAN	Transmembrane gamma-carboxyglutamic acid protein 4 (Proline-rich gamma-carboxyglutamic acid protein 4) (Proline-rich Gla protein 4)	PRRG4 PRGP4 TMG4	Homo sapiens (Human)	226	FUNCTION: May control axon guidance across the CNS (PubMed:28859078). Prevents the delivery of ROBO1 at the cell surface and down-regulates its expression (PubMed:28859078). {ECO:0000269|PubMed:28859078}.			endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; WW domain binding [GO:0050699]	endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; WW domain binding [GO:0050699]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:28859078}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:23873930}; Single-pass type I membrane protein {ECO:0000255}.
Q9BZE0	reviewed	GLIS2_HUMAN	Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein)	GLIS2 NKL	Homo sapiens (Human)	524	FUNCTION: Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}.		cell differentiation involved in kidney development [GO:0061005]; central nervous system development [GO:0007417]; hematopoietic stem cell homeostasis [GO:0061484]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytoplasm [GO:0005737]; non-motile cilium [GO:0097730]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; non-motile cilium [GO:0097730]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cell differentiation involved in kidney development [GO:0061005]; central nervous system development [GO:0007417]; hematopoietic stem cell homeostasis [GO:0061484]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q9BZE2	reviewed	PUS3_HUMAN	tRNA pseudouridine(38/39) synthase (EC 5.4.99.45) (tRNA pseudouridine synthase 3) (tRNA pseudouridylate synthase 3) (tRNA-uridine isomerase 3)	PUS3 FKSG32	Homo sapiens (Human)	481	FUNCTION: Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs. {ECO:0000269|PubMed:27055666}.		mRNA pseudouridine synthesis [GO:1990481]; tRNA modification [GO:0006400]; tRNA pseudouridine synthesis [GO:0031119]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029]; mRNA pseudouridine synthesis [GO:1990481]; tRNA modification [GO:0006400]; tRNA pseudouridine synthesis [GO:0031119]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BZE4	reviewed	GTPB4_HUMAN	GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1)	GTPBP4 CRFG NOG1	Homo sapiens (Human)	634	FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit (PubMed:32669547). Acts as TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539). {ECO:0000269|PubMed:20308539, ECO:0000269|PubMed:32669547}.		maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of collagen binding [GO:0033342]; negative regulation of DNA replication [GO:0008156]; negative regulation of protein ubiquitination [GO:0031397]; osteoblast differentiation [GO:0001649]; protein stabilization [GO:0050821]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; ribosomal large subunit biogenesis [GO:0042273]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; preribosome binding [GO:1990275]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; preribosome binding [GO:1990275]; RNA binding [GO:0003723]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of collagen binding [GO:0033342]; negative regulation of DNA replication [GO:0008156]; negative regulation of protein ubiquitination [GO:0031397]; osteoblast differentiation [GO:0001649]; protein stabilization [GO:0050821]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; ribosomal large subunit biogenesis [GO:0042273]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11316846, ECO:0000269|PubMed:12429849, ECO:0000269|Ref.8}.
Q9BZE9	reviewed	ASPC1_HUMAN	Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17) (UBX domain-containing protein 9)	ASPSCR1 ASPL RCC17 TUG UBXD9 UBXN9	Homo sapiens (Human)	553	FUNCTION: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT. {ECO:0000250, ECO:0000269|PubMed:23349634}.		glucose homeostasis [GO:0042593]; intracellular protein transport [GO:0006886]; positive regulation of protein modification process [GO:0031401]; regulation of glucose import [GO:0046324]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]		cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; glucose homeostasis [GO:0042593]; intracellular protein transport [GO:0006886]; positive regulation of protein modification process [GO:0031401]; regulation of glucose import [GO:0046324]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:22207755}; Peripheral membrane protein. Cytoplasm {ECO:0000269|PubMed:23349634}. Nucleus {ECO:0000269|PubMed:23349634}.
Q9BZF1	reviewed	OSBL8_HUMAN	Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)	OSBPL8 KIAA1451 ORP8 OSBP10	Homo sapiens (Human)	889	FUNCTION: Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}.		activation of protein kinase B activity [GO:0032148]; fat cell differentiation [GO:0045444]; negative regulation of cell migration [GO:0030336]; negative regulation of sequestering of triglyceride [GO:0010891]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid transport [GO:0015914]; positive regulation of glucose import [GO:0046326]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein localization to nuclear pore [GO:0090204]	cortical endoplasmic reticulum [GO:0032541]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear membrane [GO:0031965]	cholesterol binding [GO:0015485]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; phosphatidylserine transfer activity [GO:0140343]; phospholipid transporter activity [GO:0005548]; sterol transporter activity [GO:0015248]	cortical endoplasmic reticulum [GO:0032541]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; cholesterol binding [GO:0015485]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; phosphatidylserine transfer activity [GO:0140343]; phospholipid transporter activity [GO:0005548]; sterol transporter activity [GO:0015248]; activation of protein kinase B activity [GO:0032148]; fat cell differentiation [GO:0045444]; negative regulation of cell migration [GO:0030336]; negative regulation of sequestering of triglyceride [GO:0010891]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid transport [GO:0015914]; positive regulation of glucose import [GO:0046326]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein localization to nuclear pore [GO:0090204]	SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:26206935}; Single-pass membrane protein {ECO:0000269|PubMed:17991739}. Nucleus membrane {ECO:0000269|PubMed:21698267}. Note=The presence of the N-terminus extension contains an overall negative charge that may explain the weak localization to the cortical endoplasmic reticulum (Probable). {ECO:0000305|PubMed:26206935}.; SUBCELLULAR LOCATION: [Isoform 3]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26206935}; Single-pass membrane protein. Note=Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites. {ECO:0000269|PubMed:26206935}.
Q9BZF2	reviewed	OSBL7_HUMAN	Oxysterol-binding protein-related protein 7 (ORP-7) (OSBP-related protein 7)	OSBPL7 ORP7	Homo sapiens (Human)	842			bile acid biosynthetic process [GO:0006699]; cellular response to cholesterol [GO:0071397]; positive regulation of proteasomal protein catabolic process [GO:1901800]; regulation of autophagy [GO:0010506]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; sterol transporter activity [GO:0015248]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; sterol transporter activity [GO:0015248]; bile acid biosynthetic process [GO:0006699]; cellular response to cholesterol [GO:0071397]; positive regulation of proteasomal protein catabolic process [GO:1901800]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:14593528}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14593528}. Cell membrane {ECO:0000269|PubMed:14593528}.
Q9BZF3	reviewed	OSBL6_HUMAN	Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6)	OSBPL6 ORP6	Homo sapiens (Human)	934	FUNCTION: Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}.		bile acid biosynthetic process [GO:0006699]; regulation of cholesterol transport [GO:0032374]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; sterol transporter activity [GO:0015248]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; sterol transporter activity [GO:0015248]; bile acid biosynthetic process [GO:0006699]; regulation of cholesterol transport [GO:0032374]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:30028970}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:26941018, ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000269|PubMed:14593528}. Cell membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:26941018}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q8BXR9}.
Q9BZF9	reviewed	UACA_HUMAN	Uveal autoantigen with coiled-coil domains and ankyrin repeats	UACA KIAA1561	Homo sapiens (Human)	1416	FUNCTION: Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). {ECO:0000250}.; FUNCTION: Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity). {ECO:0000250|UniProtKB:Q8CGB3, ECO:0000250|UniProtKB:Q8HYY4}.	MISCELLANEOUS: UACA is a possible target autoantigen in Vogt-Koyanagi-Harada (VKH), Behcet disease (BD) and sarcoidosis that cause different types of panuevitis.	negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	actin binding [GO:0003779]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; actin binding [GO:0003779]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15358194}. Cytoplasm {ECO:0000269|PubMed:15358194}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15358194}. Note=Expressed diffusely in cytoplasm.
Q9BZG1	reviewed	RAB34_HUMAN	Ras-related protein Rab-34 (Ras-related protein Rab-39) (Ras-related protein Rah)	RAB34 RAB39 RAH	Homo sapiens (Human)	259	FUNCTION: Transport protein involved in the redistribution of lysosomes to the peri-Golgi region (PubMed:27113757). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity). {ECO:0000250|UniProtKB:Q64008, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:27113757}.		antigen processing and presentation [GO:0019882]; cell projection organization [GO:0030030]; Golgi to plasma membrane protein transport [GO:0043001]; lysosome localization [GO:0032418]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to plasma membrane [GO:0072659]	cilium [GO:0005929]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi stack [GO:0005795]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; vesicle [GO:0031982]	GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; small GTPase binding [GO:0031267]	cilium [GO:0005929]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi stack [GO:0005795]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; vesicle [GO:0031982]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; small GTPase binding [GO:0031267]; antigen processing and presentation [GO:0019882]; cell projection organization [GO:0030030]; Golgi to plasma membrane protein transport [GO:0043001]; lysosome localization [GO:0032418]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q64008}. Golgi apparatus {ECO:0000250|UniProtKB:Q64008}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:21255211}; Lipid-anchor {ECO:0000269|PubMed:21255211}; Cytoplasmic side {ECO:0000269|PubMed:21255211}. Cell projection, cilium {ECO:0000250|UniProtKB:Q64008}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:21255211}.
Q9BZG2	reviewed	PPAT_HUMAN	Testicular acid phosphatase (EC 3.1.3.2) (Acid phosphatase 4)	ACP4 ACPT	Homo sapiens (Human)	426	FUNCTION: May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage (PubMed:15219672). May play a role in odontogenesis (PubMed:27843125). {ECO:0000269|PubMed:15219672, ECO:0000269|PubMed:27843125}.		lysosome organization [GO:0007040]; negative regulation of ERBB4 signaling pathway [GO:0120154]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein processing [GO:0010955]; odontogenesis [GO:0042476]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; regulation of neuronal synaptic plasticity [GO:0048168]	lysosome [GO:0005764]; postsynaptic membrane [GO:0045211]	acid phosphatase activity [GO:0003993]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]	lysosome [GO:0005764]; postsynaptic membrane [GO:0045211]; acid phosphatase activity [GO:0003993]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; lysosome organization [GO:0007040]; negative regulation of ERBB4 signaling pathway [GO:0120154]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein processing [GO:0010955]; odontogenesis [GO:0042476]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; regulation of neuronal synaptic plasticity [GO:0048168]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Q9BZG8	reviewed	DPH1_HUMAN	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)	DPH1 DPH2L DPH2L1 OVCA1	Homo sapiens (Human)	438	FUNCTION: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:30877278). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Acts as a tumor suppressor (PubMed:10519411). {ECO:0000250|UniProtKB:P40487, ECO:0000269|PubMed:10519411, ECO:0000269|PubMed:30877278}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to non sense-mediated mRNA decay. {ECO:0000305}.	protein histidyl modification to diphthamide [GO:0017183]	cell junction [GO:0030054]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]	cell junction [GO:0030054]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; 2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; protein histidyl modification to diphthamide [GO:0017183]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10519411}. Cytoplasm {ECO:0000269|PubMed:10519411}. Note=Punctate, primarily perinuclear localization. {ECO:0000269|PubMed:10519411}.
Q9BZH6	reviewed	WDR11_HUMAN	WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15)	WDR11 BRWD2 KIAA1351 WDR15	Homo sapiens (Human)	1224	FUNCTION: Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). {ECO:0000269|PubMed:29263200, ECO:0000269|PubMed:29426865}.		cilium assembly [GO:0060271]; head development [GO:0060322]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; multicellular organism growth [GO:0035264]; regulation of smoothened signaling pathway [GO:0008589]; vesicle tethering to Golgi [GO:0099041]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]		axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]; cilium assembly [GO:0060271]; head development [GO:0060322]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; multicellular organism growth [GO:0035264]; regulation of smoothened signaling pathway [GO:0008589]; vesicle tethering to Golgi [GO:0099041]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:29263200}. Cytoplasm {ECO:0000269|PubMed:20887964}. Nucleus {ECO:0000269|PubMed:20887964, ECO:0000269|PubMed:29263200}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:29263200}. Cytoplasmic vesicle {ECO:0000269|PubMed:29426865}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:29426865, ECO:0000269|PubMed:34413497}. Note=Shuttles from the cilium to the nucleus in response to Hh signaling (PubMed:29263200). Might be shuttling between the nucleus and the cytoplasm (PubMed:20887964). {ECO:0000269|PubMed:20887964, ECO:0000269|PubMed:29263200}.
Q9BZI7	reviewed	REN3B_HUMAN	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X)	UPF3B RENT3B UPF3X	Homo sapiens (Human)	483	FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}.		brain development [GO:0007420]; mRNA transport [GO:0051028]; neuron projection development [GO:0031175]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of translation [GO:0045727]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; brain development [GO:0007420]; mRNA transport [GO:0051028]; neuron projection development [GO:0031175]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of translation [GO:0045727]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11113196, ECO:0000269|PubMed:11163187}. Cytoplasm {ECO:0000269|PubMed:11163187}. Note=Shuttling between the nucleus and the cytoplasm. {ECO:0000269|PubMed:11163187}.
Q9BZJ0	reviewed	CRNL1_HUMAN	Crooked neck-like protein 1 (Crooked neck homolog) (hCrn)	CRNKL1 CRN CGI-201 MSTP021	Homo sapiens (Human)	848	FUNCTION: Involved in pre-mRNA splicing process (PubMed:11991638, PubMed:12084575, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12084575, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:33509932}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12801913, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. Nucleus speckle {ECO:0000269|PubMed:12084575}. Note=Colocalizes with core spliceosomal snRNP proteins (PubMed:12084575). {ECO:0000269|PubMed:12084575}.
Q9BZJ3	reviewed	TRYD_HUMAN	Tryptase delta (EC 3.4.21.59) (Delta-tryptase) (HmMCP-3-like tryptase III) (Mast cell mMCP-7-like) (Tryptase-3)	TPSD1	Homo sapiens (Human)	242	FUNCTION: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. {ECO:0000250}.		proteolysis [GO:0006508]	extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Released from the secretory granules upon mast cell activation. {ECO:0000250}.
Q9BZJ7	reviewed	GPR62_HUMAN	G-protein coupled receptor 62 (G-protein coupled receptor GPCR8) (hGPCR8) (G-protein coupled receptor KPG_005)	GPR62	Homo sapiens (Human)	368	FUNCTION: Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). {ECO:0000269|PubMed:28827538}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling in absence of ligand [GO:0038035]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cAMP-mediated signaling [GO:0043950]	endosome [GO:0005768]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	arrestin family protein binding [GO:1990763]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]	endosome [GO:0005768]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; arrestin family protein binding [GO:1990763]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling in absence of ligand [GO:0038035]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cAMP-mediated signaling [GO:0043950]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with ARRB2 in the endosome (PubMed:28827538). {ECO:0000269|PubMed:28827538}.
Q9BZJ8	reviewed	GPR61_HUMAN	G-protein coupled receptor 61 (Biogenic amine receptor-like G-protein coupled receptor)	GPR61 BALGR GPCR3	Homo sapiens (Human)	451	FUNCTION: Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity). {ECO:0000250|UniProtKB:Q8C010, ECO:0000269|PubMed:28827538}.		G protein-coupled receptor signaling in absence of ligand [GO:0038035]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cAMP-mediated signaling [GO:0043950]	endosome [GO:0005768]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	arrestin family protein binding [GO:1990763]; G protein-coupled receptor activity [GO:0004930]	endosome [GO:0005768]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; arrestin family protein binding [GO:1990763]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling in absence of ligand [GO:0038035]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cAMP-mediated signaling [GO:0043950]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28827538, ECO:0000269|PubMed:29226084}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with ARRB2/beta-arrestin-2 in the endosome (PubMed:28827538). {ECO:0000269|PubMed:28827538}.
Q9BZK7	reviewed	TBL1R_HUMAN	F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1)	TBL1XR1 IRA1 TBLR1	Homo sapiens (Human)	514	FUNCTION: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. {ECO:0000269|PubMed:14980219}.		blastocyst hatching [GO:0001835]; chromatin organization [GO:0006325]; fat pad development [GO:0060613]; lipid catabolic process [GO:0016042]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of triglyceride metabolic process [GO:0090207]; response to dietary excess [GO:0002021]; white fat cell differentiation [GO:0050872]	histone deacetylase complex [GO:0000118]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	beta-catenin binding [GO:0008013]; histone binding [GO:0042393]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]	histone deacetylase complex [GO:0000118]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; beta-catenin binding [GO:0008013]; histone binding [GO:0042393]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]; blastocyst hatching [GO:0001835]; chromatin organization [GO:0006325]; fat pad development [GO:0060613]; lipid catabolic process [GO:0016042]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of triglyceride metabolic process [GO:0090207]; response to dietary excess [GO:0002021]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BZL1	reviewed	UBL5_HUMAN	Ubiquitin-like protein 5	UBL5	Homo sapiens (Human)	73	FUNCTION: Ubiquitin-like protein that plays a role in cell proliferation and sister chromatid cohesion by associating with spliceosomal proteins (PubMed:25092792). Participates thereby in pre-mRNA splicing by maintaining spliceosome integrity. Promotes the functional integrity of the Fanconi anemia DNA repair pathway by interacting with FANCI component and subsequently mediating the formation of FANCI homodimers (PubMed:25862789). Plays also a protective role against ER stress-induced apoptosis (PubMed:37315790). {ECO:0000269|PubMed:25092792, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:37315790}.		mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein modification process [GO:0036211]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein tag activity [GO:0031386]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein tag activity [GO:0031386]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11161819, ECO:0000269|PubMed:23726919, ECO:0000269|PubMed:37315790}. Nucleus {ECO:0000269|PubMed:23726919, ECO:0000269|PubMed:37315790}. Nucleus, Cajal body {ECO:0000269|PubMed:37315790}.
Q9BZL3	reviewed	SMIM3_HUMAN	Small integral membrane protein 3 (NGF-induced differentiation clone 67 protein) (Small membrane protein NID67)	SMIM3 C5orf62 NID67	Homo sapiens (Human)	60				membrane [GO:0016020]	identical protein binding [GO:0042802]	membrane [GO:0016020]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9BZL4	reviewed	PP12C_HUMAN	Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85)	PPP1R12C LENG3 MBS85	Homo sapiens (Human)	782	FUNCTION: Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}.		signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	enzyme inhibitor activity [GO:0004857]; phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; enzyme inhibitor activity [GO:0004857]; phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:12923170}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:12923170}.
Q9BZL6	reviewed	KPCD2_HUMAN	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2)	PRKD2 PKD2 HSPC187	Homo sapiens (Human)	878	FUNCTION: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}.		adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial tube morphogenesis [GO:0061154]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein autophosphorylation [GO:0046777]; protein kinase D signaling [GO:0089700]; protein phosphorylation [GO:0006468]; regulation of T cell apoptotic process [GO:0070232]; sphingolipid biosynthetic process [GO:0030148]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial tube morphogenesis [GO:0061154]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein autophosphorylation [GO:0046777]; protein kinase D signaling [GO:0089700]; protein phosphorylation [GO:0006468]; regulation of T cell apoptotic process [GO:0070232]; sphingolipid biosynthetic process [GO:0030148]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17962809}. Cell membrane {ECO:0000250|UniProtKB:Q15139}. Nucleus {ECO:0000269|PubMed:17962809}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:18262756}. Note=Translocation to the cell membrane is required for kinase activation. Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. {ECO:0000269|PubMed:17962809}.
Q9BZM1	reviewed	PG12A_HUMAN	Group XIIA secretory phospholipase A2 (GXII sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)	PLA2G12A PLA2G12 FKSG38 UNQ2519/PRO6012	Homo sapiens (Human)	189	FUNCTION: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine. {ECO:0000269|PubMed:12522102}.		arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12522102}. Cytoplasm {ECO:0000269|PubMed:12522102}.
Q9BZM2	reviewed	PA2GF_HUMAN	Group IIF secretory phospholipase A2 (GIIF sPLA2) (sPLA2-IIF) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2F)	PLA2G2F	Homo sapiens (Human)	168	FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines (PubMed:11112443). May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity). {ECO:0000250|UniProtKB:Q9QZT4, ECO:0000269|PubMed:11112443}.	MISCELLANEOUS: [Isoform 2]: No signal peptide could be predicted in this isoform, challenging its subcellular location within the secretory pathway and hence the formation of disulfide bonds, which are required for its activity. {ECO:0000305}.	arachidonic acid metabolic process [GO:0019369]; arachidonic acid secretion [GO:0050482]; innate immune response [GO:0045087]; lipid catabolic process [GO:0016042]; negative regulation of T cell proliferation [GO:0042130]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644]	cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543]; arachidonic acid metabolic process [GO:0019369]; arachidonic acid secretion [GO:0050482]; innate immune response [GO:0045087]; lipid catabolic process [GO:0016042]; negative regulation of T cell proliferation [GO:0042130]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000250|UniProtKB:Q9QZT4}. Cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9QZT4}.
Q9BZM3	reviewed	GSX2_HUMAN	GS homeobox 2 (Genetic-screened homeobox 2) (Homeobox protein GSH-2)	GSX2 GSH2	Homo sapiens (Human)	304	FUNCTION: Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development (PubMed:31412107). During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). {ECO:0000250|UniProtKB:P31316, ECO:0000269|PubMed:31412107}.		forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain morphogenesis [GO:0048853]; GABAergic neuron differentiation [GO:0097154]; hindbrain morphogenesis [GO:0021575]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; olfactory bulb interneuron differentiation [GO:0021889]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of cell migration [GO:0030334]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; spinal cord association neuron differentiation [GO:0021527]; subpallium neuron fate commitment [GO:0060163]; telencephalon regionalization [GO:0021978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain morphogenesis [GO:0048853]; GABAergic neuron differentiation [GO:0097154]; hindbrain morphogenesis [GO:0021575]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; olfactory bulb interneuron differentiation [GO:0021889]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of cell migration [GO:0030334]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; spinal cord association neuron differentiation [GO:0021527]; subpallium neuron fate commitment [GO:0060163]; telencephalon regionalization [GO:0021978]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:31412107}. Cytoplasm {ECO:0000269|PubMed:31412107}.
Q9BZM4	reviewed	ULBP3_HUMAN	UL16-binding protein 3 (ALCAN-gamma) (NKG2D ligand 3) (N2DL-3) (NKG2DL3) (Retinoic acid early transcript 1N)	ULBP3 N2DL3 RAET1N	Homo sapiens (Human)	244	FUNCTION: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. {ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11754823, ECO:0000269|PubMed:11777960}.	MISCELLANEOUS: UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain. {ECO:0000305}.	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	natural killer cell lectin-like receptor binding [GO:0046703]	external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; natural killer cell lectin-like receptor binding [GO:0046703]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BZM6}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9BZM6}.
Q9BZM5	reviewed	ULBP2_HUMAN	UL16-binding protein 2 (ALCAN-alpha) (NKG2D ligand 2) (N2DL-2) (NKG2DL2) (Retinoic acid early transcript 1H)	ULBP2 N2DL2 RAET1H UNQ463/PRO791	Homo sapiens (Human)	246	FUNCTION: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. {ECO:0000269|PubMed:11777960}.	MISCELLANEOUS: UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain.	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	natural killer cell lectin-like receptor binding [GO:0046703]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; natural killer cell lectin-like receptor binding [GO:0046703]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12782710}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12782710}. Endoplasmic reticulum {ECO:0000269|PubMed:12782710}. Secreted {ECO:0000269|PubMed:11444831}. Note=In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi. {ECO:0000269|PubMed:12782710}.
Q9BZM6	reviewed	ULBP1_HUMAN	UL16-binding protein 1 (ALCAN-beta) (NKG2D ligand 1) (N2DL-1) (NKG2DL1) (Retinoic acid early transcript 1I)	ULBP1 N2DL1 RAET1I	Homo sapiens (Human)	244	FUNCTION: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. {ECO:0000269|PubMed:11777960}.	MISCELLANEOUS: UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain. {ECO:0000305}.	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	natural killer cell lectin-like receptor binding [GO:0046703]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; natural killer cell lectin-like receptor binding [GO:0046703]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of T cell mediated cytotoxicity [GO:0001916]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12782710}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12782710}. Endoplasmic reticulum {ECO:0000269|PubMed:12782710}. Note=In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi. {ECO:0000269|PubMed:12782710}.
Q9BZP6	reviewed	CHIA_HUMAN	Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902)	CHIA	Homo sapiens (Human)	476	FUNCTION: Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:18824549, ECO:0000269|PubMed:19342690, ECO:0000269|PubMed:19435888}.		apoptotic process [GO:0006915]; chitin catabolic process [GO:0006032]; chitin metabolic process [GO:0006030]; immune system process [GO:0002376]; polysaccharide catabolic process [GO:0000272]; polysaccharide digestion [GO:0044245]; positive regulation of chemokine production [GO:0032722]; production of molecular mediator involved in inflammatory response [GO:0002532]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	chitin binding [GO:0008061]; chitinase activity [GO:0004568]; kinase binding [GO:0019900]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; chitin binding [GO:0008061]; chitinase activity [GO:0004568]; kinase binding [GO:0019900]; apoptotic process [GO:0006915]; chitin catabolic process [GO:0006032]; chitin metabolic process [GO:0006030]; immune system process [GO:0002376]; polysaccharide catabolic process [GO:0000272]; polysaccharide digestion [GO:0044245]; positive regulation of chemokine production [GO:0032722]; production of molecular mediator involved in inflammatory response [GO:0002532]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted. Note=Secretion depends on EGFR activity.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Q9BZQ2	reviewed	SHP1L_HUMAN	Testicular spindle-associated protein SHCBP1L (SHC SH2 domain-binding protein 1-like protein)	SHCBP1L C1orf14	Homo sapiens (Human)	653	FUNCTION: Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells. {ECO:0000250|UniProtKB:Q3TTP0}.		cell differentiation [GO:0030154]; male meiosis cytokinesis [GO:0007112]; positive regulation of chromosome organization [GO:2001252]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; meiotic spindle [GO:0072687]		cytoplasm [GO:0005737]; meiotic spindle [GO:0072687]; cell differentiation [GO:0030154]; male meiosis cytokinesis [GO:0007112]; positive regulation of chromosome organization [GO:2001252]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q3TTP0}. Note=Colocalizes with alpha tubulin during meiosis. Colocalizes with HSPA2 at spindle during the meiosis process. {ECO:0000250|UniProtKB:Q3TTP0}.
Q9BZQ4	reviewed	NMNA2_HUMAN	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMN/NaMN adenylyltransferase 2) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide mononucleotide adenylyltransferase 2) (NMN adenylyltransferase 2) (Nicotinate-nucleotide adenylyltransferase 2) (NaMN adenylyltransferase 2)	NMNAT2 C1orf15 KIAA0479	Homo sapiens (Human)	307	FUNCTION: Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed:16118205, PubMed:17402747). Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed:16118205, PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:16118205, PubMed:17402747). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PubMed:16118205, PubMed:17402747). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:16118205, PubMed:17402747). Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16 (PubMed:34314702). {ECO:0000250|UniProtKB:Q8BNJ3, ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747, ECO:0000269|PubMed:34314702}.		axon development [GO:0061564]; NAD biosynthetic process [GO:0009435]; negative regulation of cytoplasmic translation [GO:2000766]; nucleotide biosynthetic process [GO:0009165]	axon [GO:0030424]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]	ATP binding [GO:0005524]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]	axon [GO:0030424]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; ATP binding [GO:0005524]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]; axon development [GO:0061564]; NAD biosynthetic process [GO:0009435]; negative regulation of cytoplasmic translation [GO:2000766]; nucleotide biosynthetic process [GO:0009165]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16118205}; Lipid-anchor {ECO:0000250|UniProtKB:Q8BNJ3}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8BNJ3}; Lipid-anchor {ECO:0000250|UniProtKB:Q8BNJ3}. Cytoplasm {ECO:0000269|PubMed:16118205}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BNJ3}. Note=Delivered to axons with Golgi-derived cytoplasmic vesicles. {ECO:0000250|UniProtKB:Q8BNJ3}.
Q9BZQ6	reviewed	EDEM3_HUMAN	ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)	EDEM3 C1orf22	Homo sapiens (Human)	932	FUNCTION: Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans (PubMed:25092655). May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD (PubMed:34143952). May have alpha 1,2-mannosidase activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:25092655, ECO:0000269|PubMed:34143952}.		carbohydrate metabolic process [GO:0005975]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; response to unfolded protein [GO:0006986]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]; carbohydrate metabolic process [GO:0005975]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q9BZQ8	reviewed	NIBA1_HUMAN	Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A)	NIBAN1 C1orf24 FAM129A NIBAN GIG39	Homo sapiens (Human)	928	FUNCTION: Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}.	MISCELLANEOUS: 'Niban' means 'second' in Japanese.	negative regulation of protein phosphorylation [GO:0001933]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; response to endoplasmic reticulum stress [GO:0034976]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16949643}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Q9BZR6	reviewed	RTN4R_HUMAN	Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor)	RTN4R NOGOR UNQ330/PRO526	Homo sapiens (Human)	473	FUNCTION: Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). {ECO:0000250|UniProtKB:Q99PI8, ECO:0000269|PubMed:12037567, ECO:0000269|PubMed:12426574, ECO:0000269|PubMed:12839991, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:16712417, ECO:0000269|PubMed:18411262, ECO:0000269|PubMed:19052207, ECO:0000269|PubMed:28892071}.		axonogenesis [GO:0007409]; cell surface receptor signaling pathway [GO:0007166]; corpus callosum development [GO:0022038]; negative regulation of axon extension [GO:0030517]; negative regulation of axon regeneration [GO:0048681]; negative regulation of neuron projection development [GO:0010977]; neuronal signal transduction [GO:0023041]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Rho protein signal transduction [GO:0035025]	axonal growth cone [GO:0044295]; cell surface [GO:0009986]; dendritic shaft [GO:0043198]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	chondroitin sulfate binding [GO:0035374]; ganglioside GM1 binding [GO:1905573]; ganglioside GT1b binding [GO:1905576]; heparin binding [GO:0008201]; neuregulin receptor activity [GO:0038131]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]	axonal growth cone [GO:0044295]; cell surface [GO:0009986]; dendritic shaft [GO:0043198]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; chondroitin sulfate binding [GO:0035374]; ganglioside GM1 binding [GO:1905573]; ganglioside GT1b binding [GO:1905576]; heparin binding [GO:0008201]; neuregulin receptor activity [GO:0038131]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; axonogenesis [GO:0007409]; cell surface receptor signaling pathway [GO:0007166]; corpus callosum development [GO:0022038]; negative regulation of axon extension [GO:0030517]; negative regulation of axon regeneration [GO:0048681]; negative regulation of neuron projection development [GO:0010977]; neuronal signal transduction [GO:0023041]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Rho protein signal transduction [GO:0035025]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12426574, ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:12839991, ECO:0000269|PubMed:16712417, ECO:0000269|PubMed:18411262}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12694398}. Membrane raft {ECO:0000269|PubMed:12694398}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99PI8}. Cell projection, axon {ECO:0000250|UniProtKB:Q99PI8}. Perikaryon {ECO:0000250|UniProtKB:Q99M75}. Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. {ECO:0000250|UniProtKB:Q99PI8}.
Q9BZR8	reviewed	B2L14_HUMAN	Apoptosis facilitator Bcl-2-like protein 14 (Bcl2-L-14) (Apoptosis regulator Bcl-G)	BCL2L14 BCLG	Homo sapiens (Human)	327	FUNCTION: Plays a role in apoptosis.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	apoptotic process [GO:0006915]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; intracellular organelle [GO:0043229]; membrane [GO:0016020]	protein kinase binding [GO:0019901]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; intracellular organelle [GO:0043229]; membrane [GO:0016020]; protein kinase binding [GO:0019901]; apoptotic process [GO:0006915]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11054413}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol. Note=Diffusely distributed throughout the cytosol.; SUBCELLULAR LOCATION: [Isoform 2]: Endomembrane system. Note=Predominantly localized to cytosolic organelles.
Q9BZR9	reviewed	TRIM8_HUMAN	E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)	TRIM8 GERP RNF27	Homo sapiens (Human)	551	FUNCTION: E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response (PubMed:27981609, PubMed:28747347). Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (PubMed:22084099, PubMed:23152791, PubMed:27981609, PubMed:34871740). Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (PubMed:20516148). Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction (PubMed:28747347). {ECO:0000269|PubMed:12163497, ECO:0000269|PubMed:20516148, ECO:0000269|PubMed:22084099, ECO:0000269|PubMed:23152791, ECO:0000269|PubMed:28747347, ECO:0000269|PubMed:34871740}.		canonical NF-kappaB signal transduction [GO:0007249]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to nucleus [GO:1900182]; protein ubiquitination [GO:0016567]; stem cell population maintenance [GO:0019827]; suppression of viral release by host [GO:0044790]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; PML body [GO:0016605]	identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; PML body [GO:0016605]; identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; canonical NF-kappaB signal transduction [GO:0007249]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to nucleus [GO:1900182]; protein ubiquitination [GO:0016567]; stem cell population maintenance [GO:0019827]; suppression of viral release by host [GO:0044790]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23152791, ECO:0000269|PubMed:34871740}. Nucleus {ECO:0000269|PubMed:23152791, ECO:0000269|PubMed:34871740}. Nucleus, nuclear body {ECO:0000269|PubMed:33508234}. Note=Nucleo-cytoplasmic translocation is involved in regulation of NF-kappa-B. {ECO:0000269|PubMed:23152791}.
Q9BZS1	reviewed	FOXP3_HUMAN	Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form]	FOXP3 IPEX JM2	Homo sapiens (Human)	431	FUNCTION: Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:30513302, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:32644293). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781). Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity). {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18368049, ECO:0000269|PubMed:21458306, ECO:0000269|PubMed:23169781, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:32644293, ECO:0000303|PubMed:23947341, ECO:0000303|PubMed:24354325, ECO:0000303|PubMed:24722479}.		B cell homeostasis [GO:0001782]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment [GO:0002362]; chromatin remodeling [GO:0006338]; establishment of endothelial blood-brain barrier [GO:0014045]; immature T cell proliferation in thymus [GO:0033080]; inflammatory response [GO:0006954]; isotype switching to IgE isotypes [GO:0048289]; myeloid cell homeostasis [GO:0002262]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of cytokine production [GO:0001818]; negative regulation of defense response to virus [GO:0050687]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of immune response [GO:0050777]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of isotype switching to IgE isotypes [GO:0048294]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of peripheral T cell tolerance induction [GO:0002851]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell anergy [GO:0002669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914]; regulation of DNA-templated transcription [GO:0006355]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of T cell anergy [GO:0002667]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory T cell differentiation [GO:0045066]; response to lipopolysaccharide [GO:0032496]; response to rapamycin [GO:1901355]; response to virus [GO:0009615]; T cell activation [GO:0042110]; T cell anergy [GO:0002870]; T cell homeostasis [GO:0043029]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]; tolerance induction to self antigen [GO:0002513]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta1 production [GO:0032905]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; NFAT protein binding [GO:0051525]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; NFAT protein binding [GO:0051525]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor activity [GO:0003714]; B cell homeostasis [GO:0001782]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment [GO:0002362]; chromatin remodeling [GO:0006338]; establishment of endothelial blood-brain barrier [GO:0014045]; immature T cell proliferation in thymus [GO:0033080]; inflammatory response [GO:0006954]; isotype switching to IgE isotypes [GO:0048289]; myeloid cell homeostasis [GO:0002262]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of cytokine production [GO:0001818]; negative regulation of defense response to virus [GO:0050687]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of immune response [GO:0050777]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of isotype switching to IgE isotypes [GO:0048294]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of peripheral T cell tolerance induction [GO:0002851]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell anergy [GO:0002669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914]; regulation of DNA-templated transcription [GO:0006355]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of T cell anergy [GO:0002667]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory T cell differentiation [GO:0045066]; response to lipopolysaccharide [GO:0032496]; response to rapamycin [GO:1901355]; response to virus [GO:0009615]; T cell activation [GO:0042110]; T cell anergy [GO:0002870]; T cell homeostasis [GO:0043029]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]; tolerance induction to self antigen [GO:0002513]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta1 production [GO:0032905]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:22678915, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:32644293}. Cytoplasm {ECO:0000269|PubMed:22678915}. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity). {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:22678915}.
Q9BZV1	reviewed	UBXN6_HUMAN	UBX domain-containing protein 6 (UBX domain-containing protein 1)	UBXN6 UBXD1 UBXDC2	Homo sapiens (Human)	441	FUNCTION: May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). {ECO:0000269|PubMed:19275885, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26475856, ECO:0000269|PubMed:27753622}.		endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ERAD pathway [GO:0036503]; macroautophagy [GO:0016236]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ERAD pathway [GO:0036503]; macroautophagy [GO:0016236]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18656546}. Cytoplasm, cytosol {ECO:0000269|PubMed:19275885}. Membrane {ECO:0000269|PubMed:19275885}; Peripheral membrane protein {ECO:0000269|PubMed:19275885}. Nucleus {ECO:0000269|PubMed:18656546}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18656546}. Early endosome membrane {ECO:0000269|PubMed:21822278}; Peripheral membrane protein {ECO:0000305|PubMed:19275885}. Late endosome membrane {ECO:0000269|PubMed:21822278}; Peripheral membrane protein {ECO:0000305|PubMed:19275885}. Lysosome membrane {ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:27753622}; Peripheral membrane protein {ECO:0000305|PubMed:19275885}. Note=Localizes at the centrosome both in interphase and during mitosis (PubMed:18656546). May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP (PubMed:21822278). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622). {ECO:0000269|PubMed:18656546, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:27753622}.
Q9BZV2	reviewed	S19A3_HUMAN	Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3)	SLC19A3	Homo sapiens (Human)	496	FUNCTION: Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism (PubMed:11731220, PubMed:33008889, PubMed:35512554, PubMed:35724964). Has no folate transport activity (PubMed:11731220). Mediates H(+)-dependent pyridoxine transport (PubMed:33008889, PubMed:35512554, PubMed:35724964, PubMed:36456177). {ECO:0000269|PubMed:11731220, ECO:0000269|PubMed:33008889, ECO:0000269|PubMed:35512554, ECO:0000269|PubMed:35724964, ECO:0000269|PubMed:36456177}.		pyridoxine transport [GO:0031923]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine transmembrane transport [GO:0071934]; thiamine transport [GO:0015888]; thiamine-containing compound metabolic process [GO:0042723]; transmembrane transport [GO:0055085]	membrane [GO:0016020]; plasma membrane [GO:0005886]	thiamine transmembrane transporter activity [GO:0015234]	membrane [GO:0016020]; plasma membrane [GO:0005886]; thiamine transmembrane transporter activity [GO:0015234]; pyridoxine transport [GO:0031923]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine transmembrane transport [GO:0071934]; thiamine transport [GO:0015888]; thiamine-containing compound metabolic process [GO:0042723]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9BZV3	reviewed	IMPG2_HUMAN	Interphotoreceptor matrix proteoglycan 2 (Interphotoreceptor matrix proteoglycan of 200 kDa) (IPM 200) (Sialoprotein associated with cones and rods proteoglycan) (Spacrcan)	IMPG2 IPM200	Homo sapiens (Human)	1241	FUNCTION: Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin. {ECO:0000269|PubMed:10702256}.		extracellular matrix organization [GO:0030198]; protein localization [GO:0008104]; retina morphogenesis in camera-type eye [GO:0060042]; visual perception [GO:0007601]	cell projection [GO:0042995]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165]; membrane [GO:0016020]; receptor complex [GO:0043235]	extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hyaluronic acid binding [GO:0005540]	cell projection [GO:0042995]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165]; membrane [GO:0016020]; receptor complex [GO:0043235]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hyaluronic acid binding [GO:0005540]; extracellular matrix organization [GO:0030198]; protein localization [GO:0008104]; retina morphogenesis in camera-type eye [GO:0060042]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000269|PubMed:29777959}; Single-pass type I membrane protein {ECO:0000255}. Photoreceptor inner segment membrane {ECO:0000250|UniProtKB:Q80XH2}; Single-pass type I membrane protein {ECO:0000255}. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix {ECO:0000269|PubMed:10702256}.
Q9BZW2	reviewed	S13A1_HUMAN	Solute carrier family 13 member 1 (Renal sodium/sulfate cotransporter) (Na(+)/sulfate cotransporter) (hNaSi-1)	SLC13A1 NAS1 NASI1	Homo sapiens (Human)	595	FUNCTION: Sodium:sulfate symporter that mediates sulfate reabsorption in the kidney and small intestine (PubMed:11161786). Can also mediate the transport of selenate and thiosulfate (By similarity). {ECO:0000250|UniProtKB:Q07782, ECO:0000269|PubMed:11161786}.		sulfate transport [GO:0008272]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	monoatomic anion:sodium symporter activity [GO:0015373]; sodium:sulfate symporter activity [GO:0015382]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; monoatomic anion:sodium symporter activity [GO:0015373]; sodium:sulfate symporter activity [GO:0015382]; sulfate transport [GO:0008272]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q07782}; Multi-pass membrane protein {ECO:0000255}.
Q9BZW4	reviewed	TM6S2_HUMAN	Transmembrane 6 superfamily member 2	TM6SF2	Homo sapiens (Human)	377	FUNCTION: Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content (PubMed:24531328, PubMed:24927523). May function as sterol isomerase (PubMed:25566323). {ECO:0000269|PubMed:24531328, ECO:0000269|PubMed:24927523, ECO:0000303|PubMed:25566323}.		lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; regulation of lipid metabolic process [GO:0019216]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]	identical protein binding [GO:0042802]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; identical protein binding [GO:0042802]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; regulation of lipid metabolic process [GO:0019216]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25566323}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:25566323}; Multi-pass membrane protein {ECO:0000255}.
Q9BZW7	reviewed	TSG10_HUMAN	Testis-specific gene 10 protein (Testis development protein NYD-SP7)	TSGA10 CEP4L	Homo sapiens (Human)	698	FUNCTION: Plays a role in spermatogenesis (PubMed:28905369). When overexpressed, prevents nuclear localization of HIF1A (By similarity). {ECO:0000250|UniProtKB:Q6NY15, ECO:0000269|PubMed:28905369}.		spermatogenesis [GO:0007283]	centriole [GO:0005814]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]		centriole [GO:0005814]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z220}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28905369}. Note=In mature spermatozoa, localizes to the centriole and midpiece (PubMed:28905369). The 27-kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail, while the 55-kDa peptide localizes to the midpiece (By similarity). Detected in the cytoplasm of almost all spermatogonial cells within the seminiferous tubules (By similarity). {ECO:0000250|UniProtKB:Q9Z220, ECO:0000269|PubMed:28905369}.
Q9BZW8	reviewed	CD244_HUMAN	Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)	CD244 2B4	Homo sapiens (Human)	370	FUNCTION: Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity). {ECO:0000250|UniProtKB:Q07763, ECO:0000269|PubMed:10359122, ECO:0000269|PubMed:10741393, ECO:0000269|PubMed:10934222, ECO:0000269|PubMed:11714776, ECO:0000269|PubMed:11917118, ECO:0000269|PubMed:8376943, ECO:0000305|PubMed:15713798}.	MISCELLANEOUS: [Isoform 2]: Binds to CD48 with a sronger affinity than isoform 1, and interactions induces greater cytotoxicity and intracellular calcium release. {ECO:0000305}.	adaptive immune response [GO:0002250]; innate immune response [GO:0045087]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of granzyme B production [GO:0071663]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	MHC class I protein binding [GO:0042288]; signaling receptor activity [GO:0038023]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; MHC class I protein binding [GO:0042288]; signaling receptor activity [GO:0038023]; adaptive immune response [GO:0002250]; innate immune response [GO:0045087]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of granzyme B production [GO:0071663]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000305}. Note=Receptor engagement results in a recruitment to lipid drafts essential for the subsequent tyrosine phosphorylation of the ITSMs. {ECO:0000269|PubMed:11034353}.
Q9BZX2	reviewed	UCK2_HUMAN	Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2)	UCK2 UMPK	Homo sapiens (Human)	261	FUNCTION: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702, PubMed:11494055). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702). {ECO:0000269|PubMed:11306702, ECO:0000269|PubMed:11494055}.		CTP salvage [GO:0044211]; phosphorylation [GO:0016310]; UMP salvage [GO:0044206]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; identical protein binding [GO:0042802]; uridine kinase activity [GO:0004849]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; identical protein binding [GO:0042802]; uridine kinase activity [GO:0004849]; CTP salvage [GO:0044211]; phosphorylation [GO:0016310]; UMP salvage [GO:0044206]	
Q9BZX4	reviewed	ROP1B_HUMAN	Ropporin-1B (Rhophilin-associated protein 1B)	ROPN1B	Homo sapiens (Human)	212	FUNCTION: Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. {ECO:0000250|UniProtKB:Q9ESG2}.	MISCELLANEOUS: 'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.	acrosome reaction [GO:0007340]; cell-cell adhesion [GO:0098609]; cilium organization [GO:0044782]; cytoskeleton-dependent cytokinesis [GO:0061640]; flagellated sperm motility [GO:0030317]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; protein localization to cilium [GO:0061512]; regulation of protein phosphorylation [GO:0001932]; Rho protein signal transduction [GO:0007266]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; motile cilium [GO:0031514]	protein heterodimerization activity [GO:0046982]; signaling receptor complex adaptor activity [GO:0030159]	cytoplasm [GO:0005737]; motile cilium [GO:0031514]; protein heterodimerization activity [GO:0046982]; signaling receptor complex adaptor activity [GO:0030159]; acrosome reaction [GO:0007340]; cell-cell adhesion [GO:0098609]; cilium organization [GO:0044782]; cytoskeleton-dependent cytokinesis [GO:0061640]; flagellated sperm motility [GO:0030317]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; protein localization to cilium [GO:0061512]; regulation of protein phosphorylation [GO:0001932]; Rho protein signal transduction [GO:0007266]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9ESG2}. Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath. {ECO:0000250|UniProtKB:Q9ESG2}.
Q9BZY9	reviewed	TRI31_HUMAN	E3 ubiquitin-protein ligase TRIM31 (EC 2.3.2.27) (Tripartite motif-containing protein 31)	TRIM31 C6orf13 RNF	Homo sapiens (Human)	425	FUNCTION: E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates (PubMed:18773414, PubMed:27929086, PubMed:27992402). Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria (PubMed:27992402). Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation (PubMed:27929086). Regulator of Src-induced anchorage independent cell growth (By similarity). {ECO:0000250|UniProtKB:Q8R0K2, ECO:0000269|PubMed:18773414, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:27992402}.	MISCELLANEOUS: [Isoform Beta]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	antiviral innate immune response [GO:0140374]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral release from host cell [GO:0019076]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; antiviral innate immune response [GO:0140374]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18773414}. Mitochondrion {ECO:0000269|PubMed:18773414, ECO:0000269|PubMed:27992402}. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria (PubMed:18773414). Recruited t omitochondria after viral infection (PubMed:27992402). {ECO:0000269|PubMed:18773414, ECO:0000269|PubMed:27992402}.
Q9BZZ2	reviewed	SN_HUMAN	Sialoadhesin (Sialic acid-binding Ig-like lectin 1) (Siglec-1) (CD antigen CD169)	SIGLEC1 SN	Homo sapiens (Human)	1709	FUNCTION: Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed:12940982, PubMed:33489013). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs)(PubMed:28129379). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2 (PubMed:28129379, PubMed:34782760). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (PubMed:12940982). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (PubMed:26358190). {ECO:0000250|UniProtKB:Q62230, ECO:0000269|PubMed:12940982, ECO:0000269|PubMed:26358190, ECO:0000269|PubMed:28129379, ECO:0000269|PubMed:33489013, ECO:0000269|PubMed:34782760}.; FUNCTION: (Microbial infection) Facilitates viral cytoplasmic entry into activated dendritic cells via recognition of sialylated gangliosides pesent on viral membrane. {ECO:0000269|PubMed:31160823}.		cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; clathrin-dependent endocytosis of virus by host cell [GO:0075512]; inflammatory response [GO:0006954]; negative regulation of type I interferon production [GO:0032480]	early endosome [GO:0005769]; extracellular region [GO:0005576]; late endosome [GO:0005770]; membrane [GO:0016020]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; virion binding [GO:0046790]	early endosome [GO:0005769]; extracellular region [GO:0005576]; late endosome [GO:0005770]; membrane [GO:0016020]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; virion binding [GO:0046790]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; clathrin-dependent endocytosis of virus by host cell [GO:0075512]; inflammatory response [GO:0006954]; negative regulation of type I interferon production [GO:0032480]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:28129379}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Q9BZZ5	reviewed	API5_HUMAN	Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL)	API5 MIG8	Homo sapiens (Human)	524	FUNCTION: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:17112319, ECO:0000269|PubMed:19387494}.		fibroblast apoptotic process [GO:0044346]; localization [GO:0051179]; negative regulation of apoptotic process [GO:0043066]; negative regulation of fibroblast apoptotic process [GO:2000270]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	fibroblast growth factor binding [GO:0017134]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; fibroblast growth factor binding [GO:0017134]; RNA binding [GO:0003723]; fibroblast apoptotic process [GO:0044346]; localization [GO:0051179]; negative regulation of apoptotic process [GO:0043066]; negative regulation of fibroblast apoptotic process [GO:2000270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11075807}. Cytoplasm {ECO:0000269|PubMed:11075807}. Note=Mainly nuclear. Can also be cytoplasmic.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Q9C000	reviewed	NLRP1_HUMAN	NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)]	NLRP1 CARD7 DEFCAP KIAA0926 NAC NALP1	Homo sapiens (Human)	1473	FUNCTION: Acts as the sensor component of the NLRP1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis (PubMed:22665479, PubMed:12191486, PubMed:17349957, PubMed:27662089, PubMed:31484767, PubMed:33093214, PubMed:33410748, PubMed:33731929, PubMed:33731932, PubMed:35857590). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:22665479, PubMed:12191486, PubMed:17349957). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, such as cleavage by some human enteroviruses and rhinoviruses, double-stranded RNA, UV-B irradiation, or Val-boroPro inhibitor, and mediates the formation of the inflammasome polymeric complex composed of NLRP1, CASP1 and PYCARD/ASC (PubMed:22665479, PubMed:12191486, PubMed:17349957, PubMed:25562666, PubMed:30291141, PubMed:30096351, PubMed:33243852, PubMed:33093214, PubMed:33410748, PubMed:35857590). In response to pathogen-associated signals, the N-terminal part of NLRP1 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1, C-terminus), which polymerizes and associates with PYCARD/ASC to initiate the formation of the inflammasome complex: the NLRP1 inflammasome recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (PubMed:22665479, PubMed:12191486, PubMed:17349957, PubMed:32051255, PubMed:33093214). In the absence of GSDMD expression, the NLRP1 inflammasome is able to recruit and activate CASP8, leading to activation of gasdermin-E (GSDME) (PubMed:33852854, PubMed:35594856). Activation of NLRP1 inflammasome is also required for HMGB1 secretion; the active cytokines and HMGB1 stimulate inflammatory responses (PubMed:22801494). Binds ATP and shows ATPase activity (PubMed:11113115, PubMed:15212762, PubMed:33243852). Plays an important role in antiviral immunity and inflammation in the human airway epithelium (PubMed:33093214). Specifically recognizes a number of pathogen-associated signals: upon infection by human rhinoviruses 14 and 16 (HRV-14 and HRV-16), NLRP1 is cleaved and activated which triggers NLRP1-dependent inflammasome activation and IL18 secretion (PubMed:33093214). Positive-strand RNA viruses, such as Semliki forest virus and long dsRNA activate the NLRP1 inflammasome, triggering IL1B release in a NLRP1-dependent fashion (PubMed:33243852). Acts as a direct sensor for long dsRNA and thus RNA virus infection (PubMed:33243852). May also be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). The NLRP1 inflammasome is also activated in response to UV-B irradiation causing ribosome collisions: ribosome collisions cause phosphorylation and activation of NLRP1 in a MAP3K20-dependent manner, leading to pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:11113115, ECO:0000269|PubMed:12191486, ECO:0000269|PubMed:15212762, ECO:0000269|PubMed:17349957, ECO:0000269|PubMed:18511561, ECO:0000269|PubMed:22665479, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:25562666, ECO:0000269|PubMed:27662089, ECO:0000269|PubMed:30096351, ECO:0000269|PubMed:30291141, ECO:0000269|PubMed:31484767, ECO:0000269|PubMed:32051255, ECO:0000269|PubMed:33093214, ECO:0000269|PubMed:33243852, ECO:0000269|PubMed:33410748, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:33852854, ECO:0000269|PubMed:35594856, ECO:0000269|PubMed:35857590}.; FUNCTION: [NACHT, LRR and PYD domains-containing protein 1]: Constitutes the precursor of the NLRP1 inflammasome, which mediates autoproteolytic processing within the FIIND domain to generate the N-terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals. {ECO:0000269|PubMed:22087307}.; FUNCTION: [NACHT, LRR and PYD domains-containing protein 1, N-terminus]: Regulatory part that prevents formation of the NLRP1 inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of NLRP1 (NACHT, LRR and PYD domains-containing protein 1, C-terminus), preventing activation of the NLRP1 inflammasome (PubMed:33093214). In response to pathogen-associated signals, this part is ubiquitinated and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the NLRP1 inflammasome (PubMed:33093214). {ECO:0000269|PubMed:33093214}.; FUNCTION: [NACHT, LRR and PYD domains-containing protein 1, C-terminus]: Constitutes the active part of the NLRP1 inflammasome (PubMed:33093214, PubMed:33731929, PubMed:33731932). In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of NLRP1 (NACHT, LRR and PYD domains-containing protein 1, N-terminus), preventing activation of the NLRP1 inflammasome (PubMed:33093214). In response to pathogen-associated signals, the N-terminal part of NLRP1 is degraded by the proteasome, releasing this form, which polymerizes and associates with PYCARD/ASC to form of the NLRP1 inflammasome complex: the NLRP1 inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis (PubMed:33093214). {ECO:0000269|PubMed:33093214, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932}.; FUNCTION: [Isoform 2]: It is unclear whether is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). {ECO:0000269|PubMed:17349957, ECO:0000269|PubMed:22665479}.	MISCELLANEOUS: In macrophages and dendritic cells, NLRP1 inflammasome activation of CASP1 and IL1B maturation can be dampened by direct contact with activated effector and memory T-cells. This effect may be mediated by hexameric TNF ligands, such as CD40LG. {ECO:0000250|UniProtKB:Q2LKW6}.	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; cellular response to UV-B [GO:0071493]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; neuron apoptotic process [GO:0051402]; NLRP1 inflammasome complex assembly [GO:1904784]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; protein homooligomerization [GO:0051260]; pyroptosis [GO:0070269]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; response to muramyl dipeptide [GO:0032495]; self proteolysis [GO:0097264]; stress-activated protein kinase signaling cascade [GO:0031098]	canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP1 inflammasome complex [GO:0072558]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase activator activity [GO:0140608]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; molecular condensate scaffold activity [GO:0140693]; pattern recognition receptor activity [GO:0038187]; peptidase activity [GO:0008233]; protein domain specific binding [GO:0019904]; protein self-association [GO:0043621]; signaling adaptor activity [GO:0035591]	canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP1 inflammasome complex [GO:0072558]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase activator activity [GO:0140608]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; molecular condensate scaffold activity [GO:0140693]; pattern recognition receptor activity [GO:0038187]; peptidase activity [GO:0008233]; protein domain specific binding [GO:0019904]; protein self-association [GO:0043621]; signaling adaptor activity [GO:0035591]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; cellular response to UV-B [GO:0071493]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; neuron apoptotic process [GO:0051402]; NLRP1 inflammasome complex assembly [GO:1904784]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; protein homooligomerization [GO:0051260]; pyroptosis [GO:0070269]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; response to muramyl dipeptide [GO:0032495]; self proteolysis [GO:0097264]; stress-activated protein kinase signaling cascade [GO:0031098]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17418785}. Cytoplasm {ECO:0000269|PubMed:17164409}. Nucleus {ECO:0000269|PubMed:17164409}. Note=Nucleocytoplasmic distribution in lymphoid organs (probably in T-cells) and in neurons. In epithelial cells, predominantly cytoplasmic. {ECO:0000269|PubMed:17164409}.; SUBCELLULAR LOCATION: [NACHT, LRR and PYD domains-containing protein 1, C-terminus]: Inflammasome {ECO:0000269|PubMed:12191486, ECO:0000269|PubMed:22665479, ECO:0000269|PubMed:30291141, ECO:0000269|PubMed:33420028, ECO:0000269|PubMed:33420033}.; SUBCELLULAR LOCATION: [NACHT, LRR and PYD domains-containing protein 1, N-terminus]: Nucleus {ECO:0000269|PubMed:35618833}. Note=(Microbial infection) Interaction with human herpes virus 8/HHV-8 proteins ORF45 promotes translocation of the N-terminal part of NLRP1 into the nucleus, relieving autoinhibition of the NLRP1 inflammasome and leading to its activation. {ECO:0000269|PubMed:35618833}.
Q9C004	reviewed	SPY4_HUMAN	Protein sprouty homolog 4 (Spry-4)	SPRY4	Homo sapiens (Human)	299	FUNCTION: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898). {ECO:0000269|PubMed:12027893, ECO:0000269|PubMed:12717443, ECO:0000269|PubMed:15584898}.		animal organ development [GO:0048513]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; ruffle membrane [GO:0032587]	protein kinase inhibitor activity [GO:0004860]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; ruffle membrane [GO:0032587]; protein kinase inhibitor activity [GO:0004860]; animal organ development [GO:0048513]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12027893, ECO:0000269|PubMed:15584898}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor) (By similarity). Colocalizes with TESK1 in vesicular spots in the cytoplasm (PubMed:15584898). {ECO:0000250|UniProtKB:Q9WTP2, ECO:0000269|PubMed:15584898}.
Q9C005	reviewed	DPY30_HUMAN	Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L)	DPY30	Homo sapiens (Human)	99	FUNCTION: As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:19651892, ECO:0000269|PubMed:21335234}.		endosomal transport [GO:0016197]; transcription initiation-coupled chromatin remodeling [GO:0045815]	Golgi apparatus [GO:0005794]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]; trans-Golgi network [GO:0005802]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	Golgi apparatus [GO:0005794]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]; trans-Golgi network [GO:0005802]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; endosomal transport [GO:0016197]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19651892}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19651892}. Note=Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs (By similarity). {ECO:0000250}.
Q9C019	reviewed	TRI15_HUMAN	E3 ubiquitin-protein ligase TRIM15 (EC 2.3.2.27) (RING finger protein 93) (Zinc finger protein 178) (Zinc finger protein B7)	TRIM15 RNF93 ZNF178 ZNFB7	Homo sapiens (Human)	465	FUNCTION: E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis (PubMed:34142270, PubMed:23077300). Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN (PubMed:25015296). Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS (PubMed:23077300). Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm (PubMed:34871740). Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs). {ECO:0000269|PubMed:23077300, ECO:0000269|PubMed:25015296, ECO:0000269|PubMed:34142270, ECO:0000269|PubMed:34497368, ECO:0000269|PubMed:34871740}.		innate immune response [GO:0045087]; mesodermal cell fate determination [GO:0007500]; negative regulation of intracellular transport of viral material [GO:1901253]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleus [GO:0005634]	molecular sequestering activity [GO:0140313]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; molecular sequestering activity [GO:0140313]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; mesodermal cell fate determination [GO:0007500]; negative regulation of intracellular transport of viral material [GO:1901253]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34142270, ECO:0000269|PubMed:34871740}. Nucleus {ECO:0000269|PubMed:34871740}. Cell junction, focal adhesion {ECO:0000269|PubMed:25015296}. Note=Localizes to focal adhesions during the early stage of adhesion biogenesis. {ECO:0000269|PubMed:25015296}.
Q9C026	reviewed	TRIM9_HUMAN	E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING finger protein 91) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9)	TRIM9 KIAA0282 RNF91	Homo sapiens (Human)	710	FUNCTION: E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. {ECO:0000269|PubMed:20085810}.	MISCELLANEOUS: [Isoform 4]: May be due to a competing donor splice site, to exon inclusion and to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be due to intron retention. {ECO:0000305}.	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; synaptic vesicle [GO:0008021]	protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; synaptic vesicle [GO:0008021]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20085810}. Cell projection, dendrite {ECO:0000269|PubMed:20085810}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q91ZY8}. Synapse {ECO:0000250|UniProtKB:Q91ZY8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91ZY8}. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (PubMed:20085810). {ECO:0000250|UniProtKB:Q91ZY8, ECO:0000269|PubMed:20085810}.
Q9C029	reviewed	TRIM7_HUMAN	E3 ubiquitin-protein ligase TRIM7 (EC 2.3.2.27) (Glycogenin-interacting protein) (RING finger protein 90) (Tripartite motif-containing protein 7)	TRIM7 GNIP RNF90	Homo sapiens (Human)	511	FUNCTION: E3 ubiquitin-protein ligase that have both tumor-promoting and tumor-suppressing activities and functions in several biological processes including innate immunity, regulation of ferroptosis as well as cell proliferation and migration (PubMed:25851810, PubMed:32853985, PubMed:34062120). Acts as an antiviral effector against multiple viruses by targeting specific viral proteins for ubiquitination and degradation including norovirus NTPase protein or SARS-CoV-2 NSP5 and NSP8 proteins (PubMed:34062120, PubMed:35982226). Mechanistically, recognizes the C-terminal glutamine-containing motif usually generated by viral proteases that process the polyproteins and trigger their ubiquitination and subsequent degradation (PubMed:35982226, PubMed:35867826, PubMed:35893676). Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of pro-inflammatory cytokines and type I interferon (By similarity). Also plays a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128). Mediates the ubiquitination of the SIN3-HDAC chromatin remodeling complex component BRMS1 (PubMed:32853985). Modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells by ubiquitinating NCOA4, leading to its degradation (PubMed:36067704). {ECO:0000250|UniProtKB:Q923T7, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:32126128, ECO:0000269|PubMed:32853985, ECO:0000269|PubMed:34062120, ECO:0000269|PubMed:35867826, ECO:0000269|PubMed:35893676, ECO:0000269|PubMed:35982226, ECO:0000269|PubMed:36067704}.; FUNCTION: (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination. {ECO:0000269|PubMed:32641828}.		antiviral innate immune response [GO:0140374]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; antiviral innate immune response [GO:0140374]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32853985}. Cytoplasm {ECO:0000269|PubMed:32641828, ECO:0000269|PubMed:32853985, ECO:0000269|PubMed:34062120}. Golgi apparatus {ECO:0000269|PubMed:32641828}.
Q9C030	reviewed	TRIM6_HUMAN	Tripartite motif-containing protein 6 (EC 2.3.2.27) (RING finger protein 89) (RING-type E3 ubiquitin transferase TRIM6)	TRIM6 RNF89	Homo sapiens (Human)	488	FUNCTION: E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway (PubMed:24882218, PubMed:31694946). In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response (PubMed:24882218). Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhanced RIGI-mediated innate antiviral immune response (PubMed:35263596). {ECO:0000250|UniProtKB:Q8BGE7, ECO:0000269|PubMed:24882218, ECO:0000269|PubMed:31694946, ECO:0000269|PubMed:35263596}.; FUNCTION: (Microbial infection) Ubiquitinates ebolavirus protein VP35 leading to enhanced viral transcriptase activity. {ECO:0000269|PubMed:28679761, ECO:0000269|PubMed:35533195}.		antiviral innate immune response [GO:0140374]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of viral genome replication [GO:0045071]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein ubiquitination [GO:0016567]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to lipopolysaccharide [GO:0032496]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; antiviral innate immune response [GO:0140374]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of viral genome replication [GO:0045071]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein ubiquitination [GO:0016567]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:24882218, ECO:0000269|PubMed:35263596}.
Q9C035	reviewed	TRIM5_HUMAN	Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)	TRIM5 RNF88	Homo sapiens (Human)	493	FUNCTION: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057). {ECO:0000269|PubMed:12878161, ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:18312418, ECO:0000269|PubMed:21035162, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:21632761, ECO:0000269|PubMed:22291694, ECO:0000269|PubMed:25127057}.	MISCELLANEOUS: [Isoform Beta]: Probable artifact. {ECO:0000305}.; MISCELLANEOUS: [Isoform Iota]: Has dominant-negative activity against TRIM5alpha. Does not inhibit HIV-1 replication. {ECO:0000305}.	activation of innate immune response [GO:0002218]; autophagy [GO:0006914]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K63-linked ubiquitination [GO:0070534]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; suppression of viral release by host [GO:0044790]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]	identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; activation of innate immune response [GO:0002218]; autophagy [GO:0006914]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K63-linked ubiquitination [GO:0070534]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; suppression of viral release by host [GO:0044790]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25127057}. Nucleus {ECO:0000250|UniProtKB:Q0PF16}. Note=Predominantly localizes in cytoplasmic bodies (PubMed:12878161, PubMed:20357094). Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27 (By similarity). In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1 (By similarity). {ECO:0000250|UniProtKB:Q0PF16, ECO:0000269|PubMed:12878161, ECO:0000269|PubMed:20357094, ECO:0000269|PubMed:25127057}.
Q9C037	reviewed	TRIM4_HUMAN	E3 ubiquitin-protein ligase TRIM4 (EC 2.3.2.27) (RING finger protein 87) (RING-type E3 ubiquitin transferase TRIM4) (Tripartite motif-containing protein 4)	TRIM4 RNF87	Homo sapiens (Human)	500	FUNCTION: E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor RIGI, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction. {ECO:0000269|PubMed:24755855}.		innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811}.
Q9C040	reviewed	TRIM2_HUMAN	Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2)	TRIM2 KIAA0517 RNF86	Homo sapiens (Human)	744	FUNCTION: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). {ECO:0000250|UniProtKB:Q9ESN6, ECO:0000269|PubMed:24068738}.		negative regulation of translation [GO:0017148]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of neuron apoptotic process [GO:0043523]	cytoplasm [GO:0005737]	translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; negative regulation of translation [GO:0017148]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of neuron apoptotic process [GO:0043523]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36481767}.
Q9C056	reviewed	NKX62_HUMAN	Homeobox protein Nkx-6.2 (Homeobox protein NK-6 homolog B)	NKX6-2 GTX NKX6B	Homo sapiens (Human)	277	FUNCTION: Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions. {ECO:0000250|UniProtKB:D3Z4R4}.		cell differentiation [GO:0030154]; central nervous system myelination [GO:0022010]; negative regulation of cell fate commitment [GO:0010454]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oligodendrocyte differentiation [GO:0048715]; neuromuscular process controlling balance [GO:0050885]; neuron fate commitment [GO:0048663]; pancreatic A cell differentiation [GO:0003310]; positive regulation of cell fate commitment [GO:0010455]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA-templated transcription [GO:0006355]; regulation of myelination [GO:0031641]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; central nervous system myelination [GO:0022010]; negative regulation of cell fate commitment [GO:0010454]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oligodendrocyte differentiation [GO:0048715]; neuromuscular process controlling balance [GO:0050885]; neuron fate commitment [GO:0048663]; pancreatic A cell differentiation [GO:0003310]; positive regulation of cell fate commitment [GO:0010455]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA-templated transcription [GO:0006355]; regulation of myelination [GO:0031641]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:D3Z4R4}.
Q9C086	reviewed	IN80B_HUMAN	INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4)	INO80B HMGA1L4 PAPA1 ZNHIT4	Homo sapiens (Human)	356	FUNCTION: Induces growth and cell cycle arrests at the G1 phase of the cell cycle. {ECO:0000269|PubMed:15556297}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000269|PubMed:15556297}.		chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	Ino80 complex [GO:0031011]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]	Ino80 complex [GO:0031011]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15556297, ECO:0000269|PubMed:18922472}. Nucleus, nucleolus {ECO:0000269|PubMed:15556297}.
Q9C091	reviewed	GRB1L_HUMAN	GREB1-like protein (Growth regulation by estrogen in breast cancer 1-like protein)	GREB1L C18orf6 KIAA1772	Homo sapiens (Human)	1923	FUNCTION: Plays a major role in early metanephros and genital development. {ECO:0000269|PubMed:29100091}.		branching involved in ureteric bud morphogenesis [GO:0001658]; cardiac ventricle development [GO:0003231]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; mesonephric duct development [GO:0072177]; metanephros development [GO:0001656]; paramesonephric duct development [GO:0061205]; uterus development [GO:0060065]	membrane [GO:0016020]		membrane [GO:0016020]; branching involved in ureteric bud morphogenesis [GO:0001658]; cardiac ventricle development [GO:0003231]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; mesonephric duct development [GO:0072177]; metanephros development [GO:0001656]; paramesonephric duct development [GO:0061205]; uterus development [GO:0060065]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q9C093	reviewed	SPEF2_HUMAN	Sperm flagellar protein 2 (Protein KPL2)	SPEF2 KIAA1770 KPL2	Homo sapiens (Human)	1822	FUNCTION: Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis (PubMed:31278745, PubMed:31151990, PubMed:31048344). Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation (By similarity). {ECO:0000250|UniProtKB:Q8C9J3, ECO:0000269|PubMed:31048344, ECO:0000269|PubMed:31151990, ECO:0000269|PubMed:31278745}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	brain morphogenesis [GO:0048854]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; respiratory system development [GO:0060541]; skeletal system morphogenesis [GO:0048705]; sperm axoneme assembly [GO:0007288]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; manchette [GO:0002177]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]		cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; manchette [GO:0002177]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; brain morphogenesis [GO:0048854]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; respiratory system development [GO:0060541]; skeletal system morphogenesis [GO:0048705]; sperm axoneme assembly [GO:0007288]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:31048344, ECO:0000269|PubMed:31151990, ECO:0000269|PubMed:31278745}. Cytoplasm {ECO:0000250|UniProtKB:Q8C9J3}. Golgi apparatus {ECO:0000250|UniProtKB:Q8C9J3}. Note=Shows dynamic localization in developing spermatozoa. Localizes to the manchette in step 10-12 elongating spermatids. Detected in the basal body and neck area of step 13-14 spermatids. Localizes to the midpiece of the sperm tail in step 15-16 spermatids. During the epididymal transport of spermatozoa, expression in the sperm tail reduces and becomes concentrated at the distal part of the midpiece. Detected in the Golgi apparatus of late spermatocytes and round spermatids. Detected in the cytoplasm of Sertoli cells. {ECO:0000250|UniProtKB:Q8C9J3}.
Q9C098	reviewed	DCLK3_HUMAN	Serine/threonine-protein kinase DCLK3 (EC 2.7.11.1) (Doublecortin domain-containing protein 3C) (Doublecortin-like and CAM kinase-like 3) (Doublecortin-like kinase 3)	DCLK3 DCAMKL3 DCDC3C KIAA1765	Homo sapiens (Human)	648			phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q9C0A0	reviewed	CNTP4_HUMAN	Contactin-associated protein-like 4 (Cell recognition molecule Caspr4)	CNTNAP4 CASPR4 KIAA1763	Homo sapiens (Human)	1308	FUNCTION: Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; regulation of grooming behavior [GO:2000821]; regulation of synaptic transmission, dopaminergic [GO:0032225]; regulation of synaptic transmission, GABAergic [GO:0032228]	cell projection [GO:0042995]; presynaptic membrane [GO:0042734]		cell projection [GO:0042995]; presynaptic membrane [GO:0042734]; cell adhesion [GO:0007155]; regulation of grooming behavior [GO:2000821]; regulation of synaptic transmission, dopaminergic [GO:0032225]; regulation of synaptic transmission, GABAergic [GO:0032228]	SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q99P47}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q99P47}. Note=Specifically present within the presynaptic compartment of synapses. {ECO:0000250|UniProtKB:Q99P47}.
Q9C0A1	reviewed	ZFHX2_HUMAN	Zinc finger homeobox protein 2 (Zinc finger homeodomain protein 2) (ZFH-2)	ZFHX2 KIAA1056 KIAA1762 ZNF409	Homo sapiens (Human)	2572	FUNCTION: Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli. {ECO:0000269|PubMed:29253101}.		adult behavior [GO:0030534]; regulation of neuron differentiation [GO:0045664]; regulation of sensory perception of pain [GO:0051930]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; adult behavior [GO:0030534]; regulation of neuron differentiation [GO:0045664]; regulation of sensory perception of pain [GO:0051930]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29253101}.
Q9C0A6	reviewed	SETD5_HUMAN	Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5)	SETD5 KIAA1757	Homo sapiens (Human)	1442	FUNCTION: Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}.		cognition [GO:0050890]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase III [GO:0016480]; regulation of chromatin organization [GO:1902275]; regulation of DNA-templated transcription [GO:0006355]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of synapse assembly [GO:0051963]	chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rpd3L-Expanded complex [GO:0070210]; Set3 complex [GO:0034967]	histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rpd3L-Expanded complex [GO:0070210]; Set3 complex [GO:0034967]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714]; cognition [GO:0050890]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase III [GO:0016480]; regulation of chromatin organization [GO:1902275]; regulation of DNA-templated transcription [GO:0006355]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of synapse assembly [GO:0051963]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5XJV7}. Chromosome {ECO:0000250|UniProtKB:Q5XJV7}. Note=Localizes to active transcribed genes. {ECO:0000250|UniProtKB:Q5XJV7}.
Q9C0B0	reviewed	UNK_HUMAN	RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5)	UNK KIAA1753 ZC3H5 ZC3HDC5	Homo sapiens (Human)	810	FUNCTION: Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.		cell morphogenesis involved in neuron differentiation [GO:0048667]; in utero embryonic development [GO:0001701]; negative regulation of cytoplasmic translation [GO:2000766]; neuron migration [GO:0001764]	cytoplasm [GO:0005737]; polysome [GO:0005844]	metal ion binding [GO:0046872]; mRNA CDS binding [GO:1990715]; polysome binding [GO:1905538]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; polysome [GO:0005844]; metal ion binding [GO:0046872]; mRNA CDS binding [GO:1990715]; polysome binding [GO:1905538]; RNA binding [GO:0003723]; cell morphogenesis involved in neuron differentiation [GO:0048667]; in utero embryonic development [GO:0001701]; negative regulation of cytoplasmic translation [GO:2000766]; neuron migration [GO:0001764]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25737280}.
Q9C0B1	reviewed	FTO_HUMAN	Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-)	FTO KIAA1752	Homo sapiens (Human)	505	FUNCTION: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:26458103, PubMed:28002401, PubMed:30197295, PubMed:26457839, PubMed:25452335). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103, PubMed:30197295, PubMed:26457839, PubMed:25452335). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26287746, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:28017614, ECO:0000269|PubMed:29249359, ECO:0000269|PubMed:30197295}.		adipose tissue development [GO:0060612]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; mRNA destabilization [GO:0061157]; oxidative demethylation [GO:0070989]; oxidative single-stranded DNA demethylation [GO:0035552]; oxidative single-stranded RNA demethylation [GO:0035553]; regulation of brown fat cell differentiation [GO:0090335]; regulation of lipid storage [GO:0010883]; regulation of multicellular organism growth [GO:0040014]; regulation of respiratory system process [GO:0044065]; regulation of white fat cell proliferation [GO:0070350]; RNA repair [GO:0042245]; temperature homeostasis [GO:0001659]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA-N1-methyladenine dioxygenase activity [GO:0043734]; ferrous iron binding [GO:0008198]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931]; oxidative DNA demethylase activity [GO:0035516]; oxidative RNA demethylase activity [GO:0035515]; transferase activity [GO:0016740]; tRNA demethylase activity [GO:1990984]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA-N1-methyladenine dioxygenase activity [GO:0043734]; ferrous iron binding [GO:0008198]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931]; oxidative DNA demethylase activity [GO:0035516]; oxidative RNA demethylase activity [GO:0035515]; transferase activity [GO:0016740]; tRNA demethylase activity [GO:1990984]; adipose tissue development [GO:0060612]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; mRNA destabilization [GO:0061157]; oxidative demethylation [GO:0070989]; oxidative single-stranded DNA demethylation [GO:0035552]; oxidative single-stranded RNA demethylation [GO:0035553]; regulation of brown fat cell differentiation [GO:0090335]; regulation of lipid storage [GO:0010883]; regulation of multicellular organism growth [GO:0040014]; regulation of respiratory system process [GO:0044065]; regulation of white fat cell proliferation [GO:0070350]; RNA repair [GO:0042245]; temperature homeostasis [GO:0001659]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:30197295}. Nucleus speckle {ECO:0000269|PubMed:22002720}. Cytoplasm {ECO:0000269|PubMed:30197295}. Note=Localizes mainly in the nucleus, where it is able to demethylate N(6)-methyladenosine (m6A) and N(6),2'-O-dimethyladenosine cap (m6A(m)) in U6 small nuclear RNA (snRNA), N(1)-methyladenine from tRNAs and internal m6A in mRNAs (PubMed:30197295). In the cytoplasm, mediates demethylation of m6A and m6A(m) in mRNAs and N(1)-methyladenine from tRNAs (PubMed:30197295). {ECO:0000269|PubMed:30197295}.
Q9C0B2	reviewed	CFA74_HUMAN	Cilia- and flagella-associated protein 74	CFAP74 C1orf222 KIAA1751	Homo sapiens (Human)	1584	FUNCTION: As part of the central apparatus of the cilium axoneme may play a role in cilium movement. May play an important role in sperm architecture and function. {ECO:0000269|PubMed:32555313}.		axoneme assembly [GO:0035082]	axoneme [GO:0005930]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]		axoneme [GO:0005930]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; axoneme assembly [GO:0035082]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:D4P3R7}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:32555313}.
Q9C0B5	reviewed	ZDHC5_HUMAN	Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375)	ZDHHC5 KIAA1748 ZNF375	Homo sapiens (Human)	715	FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Participates also in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane. Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401}.		innate immune response [GO:0045087]; lipid transport [GO:0006869]; positive regulation of pattern recognition receptor signaling pathway [GO:0062208]; positive regulation of protein localization to phagocytic vesicle [GO:1905171]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]	cell surface [GO:0009986]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic specialization, intracellular component [GO:0099091]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	cell surface [GO:0009986]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic specialization, intracellular component [GO:0099091]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; innate immune response [GO:0045087]; lipid transport [GO:0006869]; positive regulation of pattern recognition receptor signaling pathway [GO:0062208]; positive regulation of protein localization to phagocytic vesicle [GO:1905171]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:32958780}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000269|PubMed:26334723}.
Q9C0C2	reviewed	TB182_HUMAN	182 kDa tankyrase-1-binding protein	TNKS1BP1 KIAA1741 TAB182	Homo sapiens (Human)	1729			cellular response to ionizing radiation [GO:0071479]; double-strand break repair [GO:0006302]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein autophosphorylation [GO:0031954]; telomere maintenance via telomerase [GO:0007004]	adherens junction [GO:0005912]; CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ankyrin repeat binding [GO:0071532]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; protein-containing complex binding [GO:0044877]	adherens junction [GO:0005912]; CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ankyrin repeat binding [GO:0071532]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; protein-containing complex binding [GO:0044877]; cellular response to ionizing radiation [GO:0071479]; double-strand break repair [GO:0006302]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein autophosphorylation [GO:0031954]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton. Chromosome. Note=Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.
Q9C0C4	reviewed	SEM4C_HUMAN	Semaphorin-4C	SEMA4C KIAA1739 SEMAI UNQ5855/PRO34487	Homo sapiens (Human)	833	FUNCTION: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. {ECO:0000250, ECO:0000269|PubMed:17498836}.		axon guidance [GO:0007411]; cell migration in hindbrain [GO:0021535]; cerebellum development [GO:0021549]; muscle cell differentiation [GO:0042692]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; neural tube closure [GO:0001843]; positive regulation of cell migration [GO:0030335]; positive regulation of stress-activated MAPK cascade [GO:0032874]; semaphorin-plexin signaling pathway [GO:0071526]	extracellular space [GO:0005615]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	extracellular space [GO:0005615]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; axon guidance [GO:0007411]; cell migration in hindbrain [GO:0021535]; cerebellum development [GO:0021549]; muscle cell differentiation [GO:0042692]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; neural tube closure [GO:0001843]; positive regulation of cell migration [GO:0030335]; positive regulation of stress-activated MAPK cascade [GO:0032874]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Postsynaptic density membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9C0C6	reviewed	CIPC_HUMAN	CLOCK-interacting pacemaker (CLOCK-interacting circadian protein)	CIPC KIAA1737	Homo sapiens (Human)	399	FUNCTION: Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock. {ECO:0000250|UniProtKB:Q8R0W1}.		negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; rhythmic process [GO:0048511]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26657846}. Cytoplasm, cytosol {ECO:0000269|PubMed:26657846}. Note=Predominantly localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S boundary, partially translocated to the cytosol. {ECO:0000250|UniProtKB:Q8R0W1, ECO:0000269|PubMed:26657846}.
Q9C0C7	reviewed	AMRA1_HUMAN	Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)	AMBRA1 DCAF3 KIAA1736	Homo sapiens (Human)	1298	FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:20921139, PubMed:23524951, PubMed:24587252, PubMed:33854232, PubMed:33854235, PubMed:33854239, PubMed:32333458). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23524951, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25803737, PubMed:25438055). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:25499913, PubMed:30166453). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:21358617). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (PubMed:20921139). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (PubMed:20921139). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (PubMed:23524951). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (PubMed:30217973). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (By similarity). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (By similarity). {ECO:0000250|UniProtKB:A2AH22, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24587252, ECO:0000269|PubMed:25215947, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25499913, ECO:0000269|PubMed:25803737, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32333458, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:33854239}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to starvation [GO:0009267]; mitophagy [GO:0000423]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; neural tube development [GO:0021915]; positive regulation of autophagy [GO:0010508]; positive regulation of free ubiquitin chain polymerization [GO:1904544]; positive regulation of mitophagy [GO:1901526]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of regulatory T cell differentiation [GO:0045591]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; response to mitochondrial depolarisation [GO:0098780]	autophagosome [GO:0005776]; axoneme [GO:0005930]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]	GTPase binding [GO:0051020]; protein phosphatase binding [GO:0019903]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]	autophagosome [GO:0005776]; axoneme [GO:0005930]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; GTPase binding [GO:0051020]; protein phosphatase binding [GO:0019903]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to starvation [GO:0009267]; mitophagy [GO:0000423]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; neural tube development [GO:0021915]; positive regulation of autophagy [GO:0010508]; positive regulation of free ubiquitin chain polymerization [GO:1904544]; positive regulation of mitophagy [GO:1901526]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of regulatory T cell differentiation [GO:0045591]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; response to mitochondrial depolarisation [GO:0098780]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:20921139}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20921139}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:A2AH22}. Mitochondrion {ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:25215947}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:A2AH22}. Nucleus {ECO:0000269|PubMed:32616651}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:A2AH22}. Note=Localizes to the cytoskeleton in absence of autophagy induction (PubMed:20921139). Upon autophagy induction, AMBRA1 relocalizes to the endoplasmic reticulum to enable autophagosome nucleation (PubMed:20921139). Partially localizes at mitochondria in normal conditions (PubMed:21358617). Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:A2AH22, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21358617}.
Q9C0C9	reviewed	UBE2O_HUMAN	(E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O)	UBE2O KIAA1734	Homo sapiens (Human)	1292	FUNCTION: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}.		positive regulation of BMP signaling pathway [GO:0030513]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; retrograde transport, endosome to Golgi [GO:0042147]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; positive regulation of BMP signaling pathway [GO:0030513]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24703950}. Nucleus {ECO:0000269|PubMed:24703950}. Note=Mainly localizes to the cytoplasm.
Q9C0D0	reviewed	PHAR1_HUMAN	Phosphatase and actin regulator 1	PHACTR1 KIAA1733 RPEL1	Homo sapiens (Human)	580	FUNCTION: Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}.		actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell motility [GO:0048870]; cerebral cortex development [GO:0021987]; dendrite arborization [GO:0140059]; regulation of neuron migration [GO:2001222]; stress fiber assembly [GO:0043149]	cytosol [GO:0005829]; nucleus [GO:0005634]; synapse [GO:0045202]	actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864]	cytosol [GO:0005829]; nucleus [GO:0005634]; synapse [GO:0045202]; actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864]; actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell motility [GO:0048870]; cerebral cortex development [GO:0021987]; dendrite arborization [GO:0140059]; regulation of neuron migration [GO:2001222]; stress fiber assembly [GO:0043149]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Synapse {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity). {ECO:0000250}.
Q9C0D2	reviewed	CE295_HUMAN	Centrosomal protein of 295 kDa	CEP295 KIAA1731	Homo sapiens (Human)	2601	FUNCTION: Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865). Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285}.		centriole replication [GO:0007099]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of protein acetylation [GO:1901985]; regulation of centriole replication [GO:0046599]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitotic spindle microtubule [GO:1990498]; plasma membrane [GO:0005886]	microtubule binding [GO:0008017]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitotic spindle microtubule [GO:1990498]; plasma membrane [GO:0005886]; microtubule binding [GO:0008017]; centriole replication [GO:0007099]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of protein acetylation [GO:1901985]; regulation of centriole replication [GO:0046599]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:27185865}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:27185865}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:27185865}. Note=Associates with both of the converted centrioles during G1 but becomes more enriched at the newly formed daughter (or unconverted) centrioles during S, G2, and early M phases (PubMed:25131205, PubMed:32060285). In early S phase, localized at the procentriolar microtubule wall and enriched at the proximal ends of the centrioles in CENPJ- and CEP135-dependent manner (PubMed:27185865). Colocalizes with SASS6 and CEP250 proteins (PubMed:25131205). Colocalizes with CEP135 and CEP192 at the centrosomes (PubMed:27185865). Associates with interphase microtubules and mitotic spindles (PubMed:27185865). Colocalizes with centriolar acetylated tubulin (PubMed:25131205). {ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285}.
Q9C0D3	reviewed	ZY11B_HUMAN	Protein zyg-11 homolog B	ZYG11B KIAA1730	Homo sapiens (Human)	744	FUNCTION: Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts to target substrates bearing N-terminal degrons for proteasomal degradation with the first four residues of substrates being the key recognition elements (PubMed:33093214, PubMed:34214466, PubMed:35636250). Prefers Nt-Gly but also has the capacity to recognize Nt-Ser, -Ala and -Cys (PubMed:36496439). Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098). In addition, plays a role in the amplification of cGAS to enhance innate immune response. Mechanistically, strengthens the processes of cGAS binding with dsDNA and assembling oligomers and also accelerates and stabilizes cGAS-DNA condensation, thereby enhancing production of antiviral IFNs and inflammatory cytokines (PubMed:36933219). {ECO:0000269|PubMed:31273098, ECO:0000269|PubMed:33093214, ECO:0000269|PubMed:34214466, ECO:0000269|PubMed:35636250, ECO:0000269|PubMed:36496439, ECO:0000269|PubMed:36933219}.		positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]		Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36933219}.
Q9C0D5	reviewed	TANC1_HUMAN	Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)	TANC1 KIAA1728	Homo sapiens (Human)	1861	FUNCTION: May be a scaffold component in the postsynaptic density. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: Incomplete sequence. {ECO:0000305}.	dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; regulation of postsynapse organization [GO:0099175]; visual learning [GO:0008542]	axon terminus [GO:0043679]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]		axon terminus [GO:0043679]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; regulation of postsynapse organization [GO:0099175]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250}.
Q9C0D6	reviewed	FHDC1_HUMAN	FH2 domain-containing protein 1 (Inverted formin-1)	FHDC1 INF1 KIAA1727	Homo sapiens (Human)	1143	FUNCTION: Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}.		actin filament polymerization [GO:0030041]; cilium assembly [GO:0060271]; Golgi ribbon formation [GO:0090161]; stress fiber assembly [GO:0043149]	actin filament [GO:0005884]; cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]	actin binding [GO:0003779]; microtubule binding [GO:0008017]	actin filament [GO:0005884]; cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; actin binding [GO:0003779]; microtubule binding [GO:0008017]; actin filament polymerization [GO:0030041]; cilium assembly [GO:0060271]; Golgi ribbon formation [GO:0090161]; stress fiber assembly [GO:0043149]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:29742020}. Golgi apparatus {ECO:0000250|UniProtKB:Q3ULZ2}. Note=Associates with microtubules. {ECO:0000269|PubMed:18815276}.
Q9C0D9	reviewed	EPT1_HUMAN	Ethanolaminephosphotransferase 1 (hEPT1) (EC 2.7.8.1) (Selenoprotein I) (SelI)	SELENOI EPT1 KIAA1724 SELI	Homo sapiens (Human)	397	FUNCTION: Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine/PE from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway (PubMed:17132865, PubMed:28052917, PubMed:29500230). PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes (PubMed:17132865). The enzyme is critical for the synthesis of several PE species and could also catalyze the synthesis of ether-linked phospholipids like plasmanyl- and plasmenyl-PE which could explain it is required for proper myelination and neurodevelopment (PubMed:29500230). {ECO:0000269|PubMed:17132865, ECO:0000269|PubMed:28052917, ECO:0000269|PubMed:29500230, ECO:0000303|PubMed:17132865}.		phosphatidylethanolamine biosynthetic process [GO:0006646]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	ethanolaminephosphotransferase activity [GO:0004307]; metal ion binding [GO:0046872]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; ethanolaminephosphotransferase activity [GO:0004307]; metal ion binding [GO:0046872]; phosphatidylethanolamine biosynthetic process [GO:0006646]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17132865, ECO:0000305|PubMed:28052917}; Multi-pass membrane protein {ECO:0000305|PubMed:28052917}.
Q9C0E2	reviewed	XPO4_HUMAN	Exportin-4 (Exp4)	XPO4 KIAA1721	Homo sapiens (Human)	1151	FUNCTION: Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) (PubMed:10944119, PubMed:16449645, PubMed:26787900). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins (PubMed:10944119, PubMed:16449645). Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor (PubMed:10944119, PubMed:16449645). XPO4 then return to the nuclear compartment and mediate another round of transport (PubMed:10944119, PubMed:16449645). The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10944119, PubMed:16449645). Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4 (PubMed:10944119). Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6 (PubMed:26787900). Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (By similarity). {ECO:0000250|UniProtKB:Q9ESJ0, ECO:0000269|PubMed:10944119, ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:26787900}.		positive regulation of protein export from nucleus [GO:0046827]; protein export from nucleus [GO:0006611]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267]; positive regulation of protein export from nucleus [GO:0046827]; protein export from nucleus [GO:0006611]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16449645}. Nucleus {ECO:0000269|PubMed:16449645}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:16449645}.
Q9C0E4	reviewed	GRIP2_HUMAN	Glutamate receptor-interacting protein 2 (GRIP-2)	GRIP2 KIAA1719	Homo sapiens (Human)	1043	FUNCTION: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.	artery smooth muscle contraction [GO:0014824]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; Notch signaling pathway [GO:0007219]; positive regulation of blood pressure [GO:0045777]; vesicle-mediated transport in synapse [GO:0099003]	cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]	glutamate receptor binding [GO:0035254]	cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]; glutamate receptor binding [GO:0035254]; artery smooth muscle contraction [GO:0014824]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; Notch signaling pathway [GO:0007219]; positive regulation of blood pressure [GO:0045777]; vesicle-mediated transport in synapse [GO:0099003]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q9C0E8	reviewed	LNP_HUMAN	Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark)	LNPK KIAA1715 LNP	Homo sapiens (Human)	428	FUNCTION: Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983). {ECO:0000250|UniProtKB:Q7TQ95, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:30032983}.		blood coagulation [GO:0007596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network maintenance [GO:0071788]; endoplasmic reticulum tubular network organization [GO:0071786]; limb development [GO:0060173]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; regulation of chondrocyte differentiation [GO:0032330]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; blood coagulation [GO:0007596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network maintenance [GO:0071788]; endoplasmic reticulum tubular network organization [GO:0071786]; limb development [GO:0060173]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; regulation of chondrocyte differentiation [GO:0032330]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22729086, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977}; Multi-pass membrane protein {ECO:0000269|PubMed:22729086, ECO:0000269|PubMed:24223779}; Cytoplasmic side {ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25548161}. Note=Localizes at endoplasmic reticulum (ER) three-way tubular junctions, which represent crossing-points at which the tubules build a polygonal network (PubMed:22729086, PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). {ECO:0000269|PubMed:22729086, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977}.
Q9C0F0	reviewed	ASXL3_HUMAN	Putative Polycomb group protein ASXL3 (Additional sex combs-like protein 3)	ASXL3 KIAA1713	Homo sapiens (Human)	2248	FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	animal organ morphogenesis [GO:0009887]; negative regulation of lipid biosynthetic process [GO:0051055]; positive regulation of transcription by RNA polymerase II [GO:0045944]	PR-DUB complex [GO:0035517]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; peroxisome proliferator activated receptor binding [GO:0042975]	PR-DUB complex [GO:0035517]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; peroxisome proliferator activated receptor binding [GO:0042975]; animal organ morphogenesis [GO:0009887]; negative regulation of lipid biosynthetic process [GO:0051055]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9C0F1	reviewed	CEP44_HUMAN	Centrosomal protein of 44 kDa (Cep44) (HBV PreS1-transactivated protein 3) (PS1TP3)	CEP44 KIAA1712	Homo sapiens (Human)	390	FUNCTION: Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall (PubMed:32060285). Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome (PubMed:31974111). {ECO:0000269|PubMed:31974111, ECO:0000269|PubMed:32060285}.		centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; midbody [GO:0030496]; spindle pole [GO:0000922]	microtubule binding [GO:0008017]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; midbody [GO:0030496]; spindle pole [GO:0000922]; microtubule binding [GO:0008017]; centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:31974111}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:31974111, ECO:0000269|PubMed:32060285}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:21399614}. Midbody {ECO:0000269|PubMed:21399614}. Note=Localizes to the proximal end of mother and daughter centrioles. {ECO:0000269|PubMed:31974111, ECO:0000269|PubMed:32060285}.
Q9C0F3	reviewed	ZN436_HUMAN	Zinc finger protein 436	ZNF436 KIAA1710	Homo sapiens (Human)	470	FUNCTION: May be a transcriptional repressor. {ECO:0000269|PubMed:17089209}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17089209}.
Q9C0G0	reviewed	ZN407_HUMAN	Zinc finger protein 407	ZNF407 KIAA1703	Homo sapiens (Human)	2248	FUNCTION: May be involved in transcriptional regulation.		positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleus [GO:0005634]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9C0G6	reviewed	DYH6_HUMAN	Dynein axonemal heavy chain 6 (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)	DNAH6 DNAHC6 DNHL1 HL2 KIAA1697	Homo sapiens (Human)	4158	FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). {ECO:0000250}.		cilium movement involved in cell motility [GO:0060294]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; cilium movement involved in cell motility [GO:0060294]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}.
Q9C0H2	reviewed	TTYH3_HUMAN	Protein tweety homolog 3 (hTTY3)	TTYH3 KIAA1691	Homo sapiens (Human)	523	FUNCTION: Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. {ECO:0000269|PubMed:15010458}.	MISCELLANEOUS: The current is completely inhibited by the addition of an anion permeability inhibitor. Addition of a Ca(2+) ionophore induces an outward-rectified current in mock-transfected cells, but it introduced an overt linear current in TTYH3-transfected cells.	chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]	chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; volume-sensitive chloride channel activity [GO:0072320]	chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; volume-sensitive chloride channel activity [GO:0072320]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15010458}; Multi-pass membrane protein {ECO:0000269|PubMed:15010458}.
Q9C0H9	reviewed	SRCN1_HUMAN	SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap)	SRCIN1 KIAA1684 P140 SNIP	Homo sapiens (Human)	1183	FUNCTION: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. {ECO:0000269|PubMed:14657239, ECO:0000269|PubMed:17525734, ECO:0000269|PubMed:19146815}.		exocytosis [GO:0006887]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of protein tyrosine kinase activity [GO:0061098]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; substrate adhesion-dependent cell spreading [GO:0034446]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; synapse [GO:0045202]	protein kinase binding [GO:0019901]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; synapse [GO:0045202]; protein kinase binding [GO:0019901]; exocytosis [GO:0006887]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of protein tyrosine kinase activity [GO:0061098]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QXY2}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QXY2}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QXY2}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QXY2}. Presynapse {ECO:0000250|UniProtKB:Q9QXY2}. Postsynapse {ECO:0000250|UniProtKB:Q9QXY2}. Postsynaptic density {ECO:0000250|UniProtKB:Q9QXY2}. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. {ECO:0000250|UniProtKB:Q9QXY2}.
Q9C0I1	reviewed	MTMRC_HUMAN	Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein)	MTMR12 KIAA1682 PIP3AP	Homo sapiens (Human)	747	FUNCTION: Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity). {ECO:0000250|UniProtKB:Q80TA6, ECO:0000269|PubMed:11504939, ECO:0000269|PubMed:12847286, ECO:0000269|PubMed:23818870}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; sarcomere [GO:0030017]; sarcoplasmic reticulum [GO:0016529]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; sarcomere [GO:0030017]; sarcoplasmic reticulum [GO:0016529]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12847286}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q80TA6}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q80TA6}. Note=Localizes to punctate vesicles when associated with MTM1 (PubMed:12847286). Localizes to triads, a structure formed by a T tubule and two sarcoplasmic reticulum terminal cisterna (By similarity). In skeletal muscles, co-localizes with MTM1 in the sarcomere (By similarity). Partially localizes to the sarcoplasmic reticulum in skeletal muscles (By similarity). {ECO:0000250|UniProtKB:Q80TA6, ECO:0000269|PubMed:12847286}.
Q9C0I4	reviewed	THS7B_HUMAN	Thrombospondin type-1 domain-containing protein 7B	THSD7B KIAA1679	Homo sapiens (Human)	1606			actin cytoskeleton organization [GO:0030036]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; actin cytoskeleton organization [GO:0030036]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9C0J1	reviewed	B3GN4_HUMAN	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 (EC 2.4.1.149) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4) (BGnT-4) (Beta-1,3-Gn-T4) (Beta-1,3-N-acetylglucosaminyltransferase 4) (Beta3Gn-T4)	B3GNT4 UNQ1898/PRO4344	Homo sapiens (Human)	378	FUNCTION: Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides. {ECO:0000269|PubMed:11042166}.		keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity [GO:0008457]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity [GO:0008457]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9C0J8	reviewed	WDR33_HUMAN	pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa)	WDR33 WDC146	Homo sapiens (Human)	1336	FUNCTION: Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}.		mRNA polyadenylation [GO:0006378]; postreplication repair [GO:0006301]; spermatogenesis [GO:0007283]	collagen trimer [GO:0005581]; fibrillar center [GO:0001650]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	collagen trimer [GO:0005581]; fibrillar center [GO:0001650]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA polyadenylation [GO:0006378]; postreplication repair [GO:0006301]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11162572, ECO:0000269|PubMed:19217410}.
Q9C0J9	reviewed	BHE41_HUMAN	Class E basic helix-loop-helix protein 41 (bHLHe41) (Class B basic helix-loop-helix protein 3) (bHLHb3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1)	BHLHE41 BHLHB3 DEC2 SHARP1	Homo sapiens (Human)	482	FUNCTION: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:11278948, PubMed:14672706, PubMed:15193144, PubMed:15560782, PubMed:18411297, PubMed:19786558, PubMed:25083013). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:25083013). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11 (By similarity). {ECO:0000250|UniProtKB:Q99PV5, ECO:0000269|PubMed:11278948, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:15193144, ECO:0000269|PubMed:15560782, ECO:0000269|PubMed:18411297, ECO:0000269|PubMed:19786558, ECO:0000269|PubMed:25083013}.		anterior/posterior pattern specification [GO:0009952]; circadian regulation of gene expression [GO:0032922]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; MRF binding [GO:0043426]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; MRF binding [GO:0043426]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; circadian regulation of gene expression [GO:0032922]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Q9C0K0	reviewed	BC11B_HUMAN	B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1)	BCL11B CTIP2 RIT1	Homo sapiens (Human)	894	FUNCTION: Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.	MISCELLANEOUS: [Isoform 2]: May be due to exon skipping. {ECO:0000305}.	alpha-beta T cell differentiation [GO:0046632]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; epithelial cell morphogenesis [GO:0003382]; hematopoietic stem cell migration [GO:0035701]; keratinocyte development [GO:0003334]; lymphoid lineage cell migration into thymus [GO:0097535]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of thymocyte apoptotic process [GO:0070244]; odontogenesis of dentin-containing tooth [GO:0042475]; olfactory bulb axon guidance [GO:0071678]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive T cell selection [GO:0043368]; post-embryonic camera-type eye development [GO:0031077]; regulation of keratinocyte proliferation [GO:0010837]; regulation of lipid metabolic process [GO:0019216]; regulation of neuron differentiation [GO:0045664]; striatal medium spiny neuron differentiation [GO:0021773]; T cell differentiation in thymus [GO:0033077]; T cell receptor V(D)J recombination [GO:0033153]; thymocyte apoptotic process [GO:0070242]; thymus development [GO:0048538]; transcription by RNA polymerase II [GO:0006366]	neuron projection [GO:0043005]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	neuron projection [GO:0043005]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; alpha-beta T cell differentiation [GO:0046632]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; epithelial cell morphogenesis [GO:0003382]; hematopoietic stem cell migration [GO:0035701]; keratinocyte development [GO:0003334]; lymphoid lineage cell migration into thymus [GO:0097535]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of thymocyte apoptotic process [GO:0070244]; odontogenesis of dentin-containing tooth [GO:0042475]; olfactory bulb axon guidance [GO:0071678]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive T cell selection [GO:0043368]; post-embryonic camera-type eye development [GO:0031077]; regulation of keratinocyte proliferation [GO:0010837]; regulation of lipid metabolic process [GO:0019216]; regulation of neuron differentiation [GO:0045664]; striatal medium spiny neuron differentiation [GO:0021773]; T cell differentiation in thymus [GO:0033077]; T cell receptor V(D)J recombination [GO:0033153]; thymocyte apoptotic process [GO:0070242]; thymus development [GO:0048538]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9C0K1	reviewed	S39A8_HUMAN	Metal cation symporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8)	SLC39A8 BIGM103 ZIP8 PP3105	Homo sapiens (Human)	460	FUNCTION: Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity (PubMed:12504855, PubMed:22898811, PubMed:23403290, PubMed:29337306, PubMed:26637978, PubMed:29453449). Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PubMed:27166256, PubMed:31699897). Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256). Also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:27466201). May also transport iron and cobalt through membranes (PubMed:22898811). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PubMed:29337306). Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450). Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PubMed:23403290, PubMed:28056086). Protects, for instance, cells from injury and death at the onset of inflammation (PubMed:18390834). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity). Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient (PubMed:28481222). Also participates in manganese reabsorption in the proximal tubule of the kidney (PubMed:26637978). By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain (PubMed:26637978, PubMed:31699897). With manganese cellular uptake also participates in mitochondrial proper function (PubMed:29453449). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (PubMed:19401385). {ECO:0000250|UniProtKB:Q91W10, ECO:0000269|PubMed:12504855, ECO:0000269|PubMed:18390834, ECO:0000269|PubMed:19401385, ECO:0000269|PubMed:22898811, ECO:0000269|PubMed:23403290, ECO:0000269|PubMed:26637978, ECO:0000269|PubMed:27166256, ECO:0000269|PubMed:27466201, ECO:0000269|PubMed:28056086, ECO:0000269|PubMed:28481222, ECO:0000269|PubMed:29337306, ECO:0000269|PubMed:29453449, ECO:0000269|PubMed:29927450, ECO:0000269|PubMed:31699897}.		arginine metabolic process [GO:0006525]; bicarbonate transport [GO:0015701]; cadmium ion transmembrane transport [GO:0070574]; cartilage homeostasis [GO:1990079]; cellular detoxification of cadmium ion [GO:0098849]; cobalt ion transport [GO:0006824]; DNA-templated transcription [GO:0006351]; extracellular matrix organization [GO:0030198]; intracellular manganese ion homeostasis [GO:0030026]; intracellular zinc ion homeostasis [GO:0006882]; iron ion import across plasma membrane [GO:0098711]; leukocyte adhesion to arterial endothelial cell [GO:0061757]; manganese ion transmembrane transport [GO:0071421]; mercury ion transport [GO:0015694]; mitochondrial manganese ion transmembrane transport [GO:1990540]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; plasma membrane selenite transport [GO:0097080]; protein N-linked glycosylation [GO:0006487]; regulation of DNA-templated transcription [GO:0006355]; regulation of membrane potential [GO:0042391]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lysosomal membrane [GO:0005765]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]	monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:bicarbonate symporter activity [GO:0140412]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lysosomal membrane [GO:0005765]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:bicarbonate symporter activity [GO:0140412]; arginine metabolic process [GO:0006525]; bicarbonate transport [GO:0015701]; cadmium ion transmembrane transport [GO:0070574]; cartilage homeostasis [GO:1990079]; cellular detoxification of cadmium ion [GO:0098849]; cobalt ion transport [GO:0006824]; DNA-templated transcription [GO:0006351]; extracellular matrix organization [GO:0030198]; intracellular manganese ion homeostasis [GO:0030026]; intracellular zinc ion homeostasis [GO:0006882]; iron ion import across plasma membrane [GO:0098711]; leukocyte adhesion to arterial endothelial cell [GO:0061757]; manganese ion transmembrane transport [GO:0071421]; mercury ion transport [GO:0015694]; mitochondrial manganese ion transmembrane transport [GO:1990540]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; plasma membrane selenite transport [GO:0097080]; protein N-linked glycosylation [GO:0006487]; regulation of DNA-templated transcription [GO:0006355]; regulation of membrane potential [GO:0042391]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12504855, ECO:0000269|PubMed:18390834, ECO:0000269|PubMed:29337306, ECO:0000269|PubMed:31699897}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:12504855, ECO:0000269|PubMed:18390834, ECO:0000269|PubMed:19401385}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:31699897}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:31699897}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the lysosome of activated T-cells (PubMed:19401385). A large fraction of the protein is found intracellularly in microvascular capillary endothelial cells that constitute the blood-brain barrier (PubMed:31699897). Localized and functional at both apical and basolateral membranes of microvascular capillary endothelial cells that constitute the blood-brain barrier (PubMed:31699897). {ECO:0000269|PubMed:19401385, ECO:0000269|PubMed:31699897}.
Q9C0K7	reviewed	STRAB_HUMAN	STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2)	STRADB ALS2CR2 ILPIP PRO1038	Homo sapiens (Human)	418	FUNCTION: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). {ECO:0000250, ECO:0000269|PubMed:14517248}.		activation of protein kinase activity [GO:0032147]; cell cycle [GO:0007049]; cell morphogenesis [GO:0000902]; JNK cascade [GO:0007254]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; protein export from nucleus [GO:0006611]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554]	ATP binding [GO:0005524]; protein serine/threonine kinase activator activity [GO:0043539]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554]; ATP binding [GO:0005524]; protein serine/threonine kinase activator activity [GO:0043539]; activation of protein kinase activity [GO:0032147]; cell cycle [GO:0007049]; cell morphogenesis [GO:0000902]; JNK cascade [GO:0007254]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; protein export from nucleus [GO:0006611]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14517248}. Cytoplasm {ECO:0000269|PubMed:14517248}.
Q9GZL7	reviewed	WDR12_HUMAN	Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12)	WDR12	Homo sapiens (Human)	423	FUNCTION: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:16043514, ECO:0000269|PubMed:17353269}.		maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; Notch signaling pathway [GO:0007219]; regulation of cell cycle [GO:0051726]; ribosomal large subunit biogenesis [GO:0042273]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]	ribonucleoprotein complex binding [GO:0043021]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]; ribonucleoprotein complex binding [GO:0043021]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; Notch signaling pathway [GO:0007219]; regulation of cell cycle [GO:0051726]; ribosomal large subunit biogenesis [GO:0042273]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16043514, ECO:0000269|PubMed:26601951}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:16043514}.
Q9GZM5	reviewed	YIPF3_HUMAN	Protein YIPF3 (Killer lineage protein 1) (Natural killer cell-specific antigen KLIP1) (YIP1 family member 3) [Cleaved into: Protein YIPF3, 36 kDa form III]	YIPF3 C6orf109 KLIP1	Homo sapiens (Human)	350	FUNCTION: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis. {ECO:0000269|PubMed:12490290, ECO:0000269|PubMed:21757827}.		cell differentiation [GO:0030154]	Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]		Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; cell differentiation [GO:0030154]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein. Note=Localization to the cytoplasm or to the cell membrane is developmentally and ontogenetically regulated.
Q9GZM7	reviewed	TINAL_HUMAN	Tubulointerstitial nephritis antigen-like (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2) (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP)	TINAGL1 GIS5 LCN7 OLRG2 TINAGL PP6614 PSEC0088 UNQ204/PRO230	Homo sapiens (Human)	467	FUNCTION: May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity). {ECO:0000250}.		endosomal transport [GO:0016197]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	extracellular matrix structural constituent [GO:0005201]; laminin binding [GO:0043236]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; laminin binding [GO:0043236]; endosomal transport [GO:0016197]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10799322, ECO:0000269|PubMed:11170462}.
Q9GZM8	reviewed	NDEL1_HUMAN	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1)	NDEL1 EOPA MITAP1 NUDEL	Homo sapiens (Human)	345	FUNCTION: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). {ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710}.		cell migration [GO:0016477]; central nervous system neuron axonogenesis [GO:0021955]; centrosome localization [GO:0051642]; cerebral cortex radially oriented cell migration [GO:0021799]; chromosome segregation [GO:0007059]; establishment of chromosome localization [GO:0051303]; establishment of mitotic spindle orientation [GO:0000132]; inner cell mass cell proliferation [GO:0001833]; insulin receptor signaling pathway [GO:0008286]; lysosome localization [GO:0032418]; microtubule nucleation [GO:0007020]; mitotic centrosome separation [GO:0007100]; neurofilament cytoskeleton organization [GO:0060052]; neuron projection extension [GO:1990138]; positive regulation of GTPase activity [GO:0043547]; positive regulation of ruffle assembly [GO:1900029]; radial glia-guided pyramidal neuron migration [GO:0140650]; regulation of intracellular protein transport [GO:0033157]; regulation of neuron projection development [GO:0010975]; retrograde axonal transport [GO:0008090]; vesicle transport along microtubule [GO:0047496]	axon cytoplasm [GO:1904115]; axon hillock [GO:0043203]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; neurofilament cytoskeleton [GO:0060053]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]	alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	axon cytoplasm [GO:1904115]; axon hillock [GO:0043203]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; neurofilament cytoskeleton [GO:0060053]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; cell migration [GO:0016477]; central nervous system neuron axonogenesis [GO:0021955]; centrosome localization [GO:0051642]; cerebral cortex radially oriented cell migration [GO:0021799]; chromosome segregation [GO:0007059]; establishment of chromosome localization [GO:0051303]; establishment of mitotic spindle orientation [GO:0000132]; inner cell mass cell proliferation [GO:0001833]; insulin receptor signaling pathway [GO:0008286]; lysosome localization [GO:0032418]; microtubule nucleation [GO:0007020]; mitotic centrosome separation [GO:0007100]; neurofilament cytoskeleton organization [GO:0060052]; neuron projection extension [GO:1990138]; positive regulation of GTPase activity [GO:0043547]; positive regulation of ruffle assembly [GO:1900029]; radial glia-guided pyramidal neuron migration [GO:0140650]; regulation of intracellular protein transport [GO:0033157]; regulation of neuron projection development [GO:0010975]; retrograde axonal transport [GO:0008090]; vesicle transport along microtubule [GO:0047496]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner. {ECO:0000250}.
Q9GZN0	reviewed	GPR88_HUMAN	Probable G-protein coupled receptor 88 (Striatum-specific G-protein coupled receptor)	GPR88 STRG	Homo sapiens (Human)	384	FUNCTION: Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function. {ECO:0000250|UniProtKB:Q9EPB7, ECO:0000250|UniProtKB:Q9ESP4}.		cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; locomotory behavior [GO:0007626]; motor learning [GO:0061743]; neuromuscular process controlling balance [GO:0050885]; neuronal action potential [GO:0019228]; phototransduction [GO:0007602]	cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cytoskeletal motor activity [GO:0003774]; G protein-coupled photoreceptor activity [GO:0008020]	cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cytoskeletal motor activity [GO:0003774]; G protein-coupled photoreceptor activity [GO:0008020]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; locomotory behavior [GO:0007626]; motor learning [GO:0061743]; neuromuscular process controlling balance [GO:0050885]; neuronal action potential [GO:0019228]; phototransduction [GO:0007602]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9ESP4}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9ESP4}. Nucleus {ECO:0000250|UniProtKB:Q9ESP4}. Note=During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood. {ECO:0000250|UniProtKB:Q9ESP4}.
Q9GZN1	reviewed	ARP6_HUMAN	Actin-related protein 6 (hArp6) (hARPX)	ACTR6 CDA12	Homo sapiens (Human)	396	FUNCTION: Required for formation and/or maintenance of proper nucleolar structure and function (PubMed:26164235). Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription (By similarity). In the presence of high glucose, maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z (By similarity). {ECO:0000250|UniProtKB:Q9DEE9, ECO:0000269|PubMed:26164235}.		chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase I [GO:0016479]; nucleolus organization [GO:0007000]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of DNA-templated transcription [GO:0006355]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleolus [GO:0005730]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]	nucleosome binding [GO:0031491]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleolus [GO:0005730]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]; nucleosome binding [GO:0031491]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase I [GO:0016479]; nucleolus organization [GO:0007000]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P45890}. Nucleus {ECO:0000269|PubMed:16487625}. Nucleus, nucleolus {ECO:0000269|PubMed:26164235}. Note=Colocalizes with HP1 family proteins at pericentric heterochromatin. {ECO:0000269|PubMed:16487625}.
Q9GZN2	reviewed	TGIF2_HUMAN	Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2)	TGIF2	Homo sapiens (Human)	237	FUNCTION: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. {ECO:0000269|PubMed:11427533}.	MISCELLANEOUS: TGIF2 is amplified and overexpressed in several ovarian cancer cell lines.	amacrine cell differentiation [GO:0035881]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nodal signaling pathway [GO:0038092]; positive regulation of amacrine cell differentiation [GO:1902871]; regulation of DNA-templated transcription [GO:0006355]; regulation of gastrulation [GO:0010470]	centrosome [GO:0005813]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	centrosome [GO:0005813]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; amacrine cell differentiation [GO:0035881]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nodal signaling pathway [GO:0038092]; positive regulation of amacrine cell differentiation [GO:1902871]; regulation of DNA-templated transcription [GO:0006355]; regulation of gastrulation [GO:0010470]	SUBCELLULAR LOCATION: Nucleus. Note=Excluded from nucleoli.
Q9GZN4	reviewed	BSSP4_HUMAN	Brain-specific serine protease 4 (BSSP-4) (EC 3.4.21.-) (Serine protease 22) (Serine protease 26) (Tryptase epsilon)	PRSS22 BSSP4 PRSS26 SP001LA UNQ302/PRO343	Homo sapiens (Human)	317	FUNCTION: Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. {ECO:0000269|PubMed:11602603}.		positive regulation of peptidase activity [GO:0010952]; proteolysis [GO:0006508]	extracellular space [GO:0005615]	peptidase activator activity [GO:0016504]; serine-type endopeptidase activity [GO:0004252]	extracellular space [GO:0005615]; peptidase activator activity [GO:0016504]; serine-type endopeptidase activity [GO:0004252]; positive regulation of peptidase activity [GO:0010952]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11602603}.
Q9GZN7	reviewed	ROGDI_HUMAN	Protein rogdi homolog	ROGDI	Homo sapiens (Human)	287			brain development [GO:0007420]; hemopoiesis [GO:0030097]; neurogenesis [GO:0022008]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell population proliferation [GO:0008284]	axon [GO:0030424]; dendrite [GO:0030425]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nuclear envelope [GO:0005635]; perikaryon [GO:0043204]; RAVE complex [GO:0043291]; synaptic vesicle [GO:0008021]		axon [GO:0030424]; dendrite [GO:0030425]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nuclear envelope [GO:0005635]; perikaryon [GO:0043204]; RAVE complex [GO:0043291]; synaptic vesicle [GO:0008021]; brain development [GO:0007420]; hemopoiesis [GO:0030097]; neurogenesis [GO:0022008]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:22482807}. Presynapse {ECO:0000250|UniProtKB:Q4V7D2}. Cell projection, axon {ECO:0000250|UniProtKB:Q4V7D2}. Perikaryon {ECO:0000250|UniProtKB:Q4V7D2}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q4V7D2}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q4V7D2}. Note=Detected primarily at presynaptic sites on axons, and to a lesser degree in soma and dendrites. Not detected at post-synaptic sites. {ECO:0000250|UniProtKB:Q4V7D2}.
Q9GZP0	reviewed	PDGFD_HUMAN	Platelet-derived growth factor D (PDGF-D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)]	PDGFD IEGF SCDGFB MSTP036 UNQ1899/PRO4345	Homo sapiens (Human)	370	FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). {ECO:0000250, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:15271796}.		cellular response to amino acid stimulus [GO:0071230]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to transforming growth factor beta stimulus [GO:0071560]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]	growth factor activity [GO:0008083]; platelet-derived growth factor receptor binding [GO:0005161]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; growth factor activity [GO:0008083]; platelet-derived growth factor receptor binding [GO:0005161]; cellular response to amino acid stimulus [GO:0071230]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to transforming growth factor beta stimulus [GO:0071560]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11331882}. Note=Released by platelets upon wounding.
Q9GZP9	reviewed	DERL2_HUMAN	Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa)	DERL2 DER2 FLANA CGI-101 SBBI53	Homo sapiens (Human)	239	FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189). May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). {ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:26565908}.; FUNCTION: (Microbial infection) In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. {ECO:0000269|PubMed:15215855}.		endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; retrograde protein transport, ER to cytosol [GO:0030970]; suckling behavior [GO:0001967]; ubiquitin-dependent ERAD pathway [GO:0030433]	early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; late endosome [GO:0005770]; membrane [GO:0016020]	misfolded protein binding [GO:0051787]; protein-containing complex binding [GO:0044877]; signal recognition particle binding [GO:0005047]; ubiquitin-specific protease binding [GO:1990381]	early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; late endosome [GO:0005770]; membrane [GO:0016020]; misfolded protein binding [GO:0051787]; protein-containing complex binding [GO:0044877]; signal recognition particle binding [GO:0005047]; ubiquitin-specific protease binding [GO:1990381]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; retrograde protein transport, ER to cytosol [GO:0030970]; suckling behavior [GO:0001967]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}; Multi-pass membrane protein {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}.
Q9GZQ4	reviewed	NMUR2_HUMAN	Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor FM-4) (G-protein coupled receptor TGR-1)	NMUR2 NMU2R TGR1	Homo sapiens (Human)	415	FUNCTION: Receptor for the neuromedin-U and neuromedin-S neuropeptides. {ECO:0000250, ECO:0000269|PubMed:10899166}.		arachidonic acid secretion [GO:0050482]; cell-cell signaling [GO:0007267]; central nervous system development [GO:0007417]; feeding behavior [GO:0007631]; grooming behavior [GO:0007625]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium-mediated signaling [GO:0050850]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of smooth muscle contraction [GO:0006940]; response to pain [GO:0048265]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; GTP binding [GO:0005525]; intracellular calcium activated chloride channel activity [GO:0005229]; neuromedin U binding [GO:0042924]; neuromedin U receptor activity [GO:0001607]; neuropeptide receptor activity [GO:0008188]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; GTP binding [GO:0005525]; intracellular calcium activated chloride channel activity [GO:0005229]; neuromedin U binding [GO:0042924]; neuromedin U receptor activity [GO:0001607]; neuropeptide receptor activity [GO:0008188]; arachidonic acid secretion [GO:0050482]; cell-cell signaling [GO:0007267]; central nervous system development [GO:0007417]; feeding behavior [GO:0007631]; grooming behavior [GO:0007625]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium-mediated signaling [GO:0050850]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of smooth muscle contraction [GO:0006940]; response to pain [GO:0048265]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9GZQ6	reviewed	NPFF1_HUMAN	Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022)	NPFFR1 GPR147 NPFF1	Homo sapiens (Human)	430	FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.		cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]	cilium [GO:0005929]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; peptide binding [GO:0042277]	cilium [GO:0005929]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; peptide binding [GO:0042277]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9GZQ8	reviewed	MLP3B_HUMAN	Microtubule-associated proteins 1A/1B light chain 3B (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (MAP1A/MAP1B light chain 3 B) (MAP1A/MAP1B LC3 B) (Microtubule-associated protein 1 light chain 3 beta)	MAP1LC3B MAP1ALC3	Homo sapiens (Human)	125	FUNCTION: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20418806, PubMed:23209295, PubMed:28017329). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:23209295, PubMed:28017329). In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria (PubMed:22922758). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295, PubMed:28017329). Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway (PubMed:24089205). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538). Upon nutrient stress, directly recruits cofactor JMY to the phagophore membrane surfaces and promotes JMY's actin nucleation activity and autophagosome biogenesis during autophagy (PubMed:30420355). {ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:22922758, ECO:0000269|PubMed:23209295, ECO:0000269|PubMed:24089205, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:30420355, ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}.		autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; organelle membrane [GO:0031090]	ceramide binding [GO:0097001]; microtubule binding [GO:0008017]; phosphatidylethanolamine binding [GO:0008429]; ubiquitin protein ligase binding [GO:0031625]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; organelle membrane [GO:0031090]; ceramide binding [GO:0097001]; microtubule binding [GO:0008017]; phosphatidylethanolamine binding [GO:0008429]; ubiquitin protein ligase binding [GO:0031625]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:22311637, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:31315929, ECO:0000269|PubMed:33499712}; Lipid-anchor {ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:29458288}. Endomembrane system {ECO:0000269|PubMed:12740394}; Lipid-anchor {ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:29458288}. Mitochondrion membrane {ECO:0000269|PubMed:25215947, ECO:0000269|PubMed:28017329}; Lipid-anchor {ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:29458288}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9CQV6}. Cytoplasmic vesicle {ECO:0000269|PubMed:30420355}. Note=LC3-II binds to the autophagic membranes. LC3-II localizes with the mitochondrial inner membrane during Parkin-mediated mitophagy (PubMed:28017329). Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000269|PubMed:28017329}.
Q9GZR1	reviewed	SENP6_HUMAN	Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6)	SENP6 KIAA0797 SSP1 SUSP1 FKSG6	Homo sapiens (Human)	1112	FUNCTION: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}.		protein desumoylation [GO:0016926]; protein modification by small protein removal [GO:0070646]; protein sumoylation [GO:0016925]; regulation of kinetochore assembly [GO:0090234]; regulation of spindle assembly [GO:0090169]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	SUMO-specific endopeptidase activity [GO:0070139]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SUMO-specific endopeptidase activity [GO:0070139]; protein desumoylation [GO:0016926]; protein modification by small protein removal [GO:0070646]; protein sumoylation [GO:0016925]; regulation of kinetochore assembly [GO:0090234]; regulation of spindle assembly [GO:0090169]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875}.
Q9GZR2	reviewed	REXO4_HUMAN	RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2)	REXO4 PMC2 XPMC2H	Homo sapiens (Human)	422			DNA catabolic process [GO:0006308]; DNA repair [GO:0006281]; regulation of DNA-templated transcription [GO:0006355]; rRNA processing [GO:0006364]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5' exonuclease activity [GO:0008408]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; exonuclease activity [GO:0004527]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5' exonuclease activity [GO:0008408]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; exonuclease activity [GO:0004527]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; DNA catabolic process [GO:0006308]; DNA repair [GO:0006281]; regulation of DNA-templated transcription [GO:0006355]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10908561, ECO:0000269|PubMed:12429849}.
Q9GZR5	reviewed	ELOV4_HUMAN	Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4)	ELOVL4	Homo sapiens (Human)	314	FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. {ECO:0000255|HAMAP-Rule:MF_03204, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:23479632}.		fatty acid biosynthetic process [GO:0006633]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	fatty acid elongase activity [GO:0009922]; G protein-coupled photoreceptor activity [GO:0008020]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fatty acid elongase activity [GO:0009922]; G protein-coupled photoreceptor activity [GO:0008020]; fatty acid biosynthetic process [GO:0006633]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03204, ECO:0000269|PubMed:16036915, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03204}.
Q9GZS0	reviewed	DNAI2_HUMAN	Dynein axonemal intermediate chain 2 (Axonemal dynein intermediate chain 2)	DNAI2	Homo sapiens (Human)	605	FUNCTION: Part of the dynein complex of respiratory cilia.		cilium assembly [GO:0060271]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; outer dynein arm assembly [GO:0036158]	axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein axonemal particle [GO:0120293]; external side of plasma membrane [GO:0009897]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126]	dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; microtubule motor activity [GO:0003777]	axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein axonemal particle [GO:0120293]; external side of plasma membrane [GO:0009897]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; microtubule motor activity [GO:0003777]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; outer dynein arm assembly [GO:0036158]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:33139725}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q4QR00}. Note=Located in the proximal region of respiratory cilia. {ECO:0000269|PubMed:33139725}.
Q9GZS1	reviewed	RPA49_HUMAN	DNA-directed RNA polymerase I subunit RPA49 (RNA polymerase I subunit A49) (DNA-directed RNA polymerase I subunit E) (RNA polymerase I-associated factor 1) (RNA polymerase I-associated factor 53)	POLR1E PAF53 PRAF1	Homo sapiens (Human)	419	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors (PubMed:24207024). Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:24207024). {ECO:0000269|PubMed:24207024}.	MISCELLANEOUS: [Isoform 1]: Dubious isoform produced through intron retention. {ECO:0000305}.	nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; RNA polymerase I preinitiation complex assembly [GO:0001188]; transcription elongation by RNA polymerase I [GO:0006362]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]	DNA binding [GO:0003677]; RNA polymerase I general transcription initiation factor binding [GO:0001179]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]; DNA binding [GO:0003677]; RNA polymerase I general transcription initiation factor binding [GO:0001179]; nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; RNA polymerase I preinitiation complex assembly [GO:0001188]; transcription elongation by RNA polymerase I [GO:0006362]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:24207024}.
Q9GZS3	reviewed	SKI8_HUMAN	Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)]	SKIC8 WDR61	Homo sapiens (Human)	305	FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency (PubMed:16307923, PubMed:19952111, PubMed:20178742). PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1 (PubMed:16307923, PubMed:19952111, PubMed:20178742). PAF1C is required for transcription of Hox and Wnt target genes (PubMed:16307923, PubMed:19952111, PubMed:20178742). PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL (PubMed:16307923, PubMed:19952111, PubMed:20178742). PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3) (PubMed:16307923, PubMed:19952111, PubMed:20178742). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription (PubMed:16307923, PubMed:19952111, PubMed:20178742). PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors (PubMed:16307923, PubMed:19952111, PubMed:20178742). In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription (PubMed:16307923, PubMed:19952111, PubMed:20178742). Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription (PubMed:16307923, PubMed:19952111, PubMed:20178742). Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:32006463, ECO:0000269|PubMed:35120588}.		negative regulation of myeloid cell differentiation [GO:0045638]; nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled ribosome [GO:0072344]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055]	Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Ski complex [GO:0055087]		Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Ski complex [GO:0055087]; negative regulation of myeloid cell differentiation [GO:0045638]; nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled ribosome [GO:0072344]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:18445686}. Cytoplasm {ECO:0000269|PubMed:18445686, ECO:0000305|PubMed:16024656}.
Q9GZS9	reviewed	CHST5_HUMAN	Carbohydrate sulfotransferase 5 (EC 2.8.2.-) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha) (GST4-alpha) (Intestinal N-acetylglucosamine-6-O-sulfotransferase) (I-GlcNAc6ST) (Intestinal GlcNAc-6-sulfotransferase) (hIGn6ST) (N-acetylglucosamine 6-O-sulfotransferase 3) (GlcNAc6ST-3) (Gn6st-3)	CHST5	Homo sapiens (Human)	411	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location. {ECO:0000269|PubMed:10491328, ECO:0000269|PubMed:11352640, ECO:0000269|PubMed:12218059, ECO:0000269|PubMed:12626414}.		carbohydrate metabolic process [GO:0005975]; keratan sulfate biosynthetic process [GO:0018146]; N-acetylglucosamine metabolic process [GO:0006044]; protein sulfation [GO:0006477]; sulfur compound metabolic process [GO:0006790]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146]; carbohydrate metabolic process [GO:0005975]; keratan sulfate biosynthetic process [GO:0018146]; N-acetylglucosamine metabolic process [GO:0006044]; protein sulfation [GO:0006477]; sulfur compound metabolic process [GO:0006790]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:12855678}; Single-pass type II membrane protein {ECO:0000305|PubMed:12855678}. Note=Golgi membrane, early secretory pathway.
Q9GZT3	reviewed	SLIRP_HUMAN	SRA stem-loop-interacting RNA-binding protein, mitochondrial	SLIRP C14orf156 DC23 DC50 PD04872	Homo sapiens (Human)	109	FUNCTION: RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. {ECO:0000269|PubMed:16762838}.		flagellated sperm motility [GO:0030317]; mitochondrion morphogenesis [GO:0070584]; negative regulation of mitochondrial RNA catabolic process [GO:0000961]; single fertilization [GO:0007338]; spermatid development [GO:0007286]	acrosomal vesicle [GO:0001669]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; sperm flagellum [GO:0036126]	RNA binding [GO:0003723]	acrosomal vesicle [GO:0001669]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; sperm flagellum [GO:0036126]; RNA binding [GO:0003723]; flagellated sperm motility [GO:0030317]; mitochondrion morphogenesis [GO:0070584]; negative regulation of mitochondrial RNA catabolic process [GO:0000961]; single fertilization [GO:0007338]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16762838}. Nucleus {ECO:0000269|PubMed:16762838}. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.
Q9GZT4	reviewed	SRR_HUMAN	Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17)	SRR	Homo sapiens (Human)	340	FUNCTION: Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. {ECO:0000269|PubMed:11054547, ECO:0000269|PubMed:20106978}.		D-serine biosynthetic process [GO:0070179]; D-serine metabolic process [GO:0070178]; L-serine metabolic process [GO:0006563]; pyruvate biosynthetic process [GO:0042866]; response to lipopolysaccharide [GO:0032496]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; serine family amino acid metabolic process [GO:0009069]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; D-serine ammonia-lyase activity [GO:0008721]; glycine binding [GO:0016594]; identical protein binding [GO:0042802]; L-serine ammonia-lyase activity [GO:0003941]; magnesium ion binding [GO:0000287]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine racemase activity [GO:0030378]; threonine racemase activity [GO:0018114]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; D-serine ammonia-lyase activity [GO:0008721]; glycine binding [GO:0016594]; identical protein binding [GO:0042802]; L-serine ammonia-lyase activity [GO:0003941]; magnesium ion binding [GO:0000287]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine racemase activity [GO:0030378]; threonine racemase activity [GO:0018114]; D-serine biosynthetic process [GO:0070179]; D-serine metabolic process [GO:0070178]; L-serine metabolic process [GO:0006563]; pyruvate biosynthetic process [GO:0042866]; response to lipopolysaccharide [GO:0032496]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; serine family amino acid metabolic process [GO:0009069]	
Q9GZT5	reviewed	WN10A_HUMAN	Protein Wnt-10a	WNT10A	Homo sapiens (Human)	417	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954). Required for normal tooth development (PubMed:17847007, PubMed:29178643, PubMed:28589954). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954). Required for normal hair follicle function (PubMed:28589954). {ECO:0000250|UniProtKB:P70701, ECO:0000269|PubMed:17847007, ECO:0000269|PubMed:28589954, ECO:0000269|PubMed:29178643, ECO:0000305}.		canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; epidermis morphogenesis [GO:0048730]; hair follicle development [GO:0001942]; hair follicle morphogenesis [GO:0031069]; neural crest cell differentiation [GO:0014033]; neuron differentiation [GO:0030182]; odontogenesis [GO:0042476]; positive regulation of gene expression [GO:0010628]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; sebaceous gland development [GO:0048733]; skin development [GO:0043588]; tongue development [GO:0043586]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; epidermis morphogenesis [GO:0048730]; hair follicle development [GO:0001942]; hair follicle morphogenesis [GO:0031069]; neural crest cell differentiation [GO:0014033]; neuron differentiation [GO:0030182]; odontogenesis [GO:0042476]; positive regulation of gene expression [GO:0010628]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; sebaceous gland development [GO:0048733]; skin development [GO:0043588]; tongue development [GO:0043586]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
Q9GZT8	reviewed	NIF3L_HUMAN	NIF3-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein)	NIF3L1 ALS2CR1 MDS015 My018	Homo sapiens (Human)	377	FUNCTION: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. {ECO:0000250|UniProtKB:Q9EQ80}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11124544, ECO:0000269|PubMed:12951069}. Nucleus {ECO:0000250|UniProtKB:Q9EQ80}. Note=Interaction with COPS2 may regulate localization to the nucleus. {ECO:0000250|UniProtKB:Q9EQ80}.
Q9GZT9	reviewed	EGLN1_HUMAN	Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)	EGLN1 C1orf12 PNAS-118 PNAS-137	Homo sapiens (Human)	426	FUNCTION: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif. {ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:12351678, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:21792862, ECO:0000269|PubMed:25129147}.	MISCELLANEOUS: [Isoform 2]: Inactive isoform. {ECO:0000305}.	cardiac muscle tissue morphogenesis [GO:0055008]; cellular response to hypoxia [GO:0071456]; heart trabecula formation [GO:0060347]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; labyrinthine layer development [GO:0060711]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of modification of postsynaptic structure [GO:0099159]; regulation protein catabolic process at postsynapse [GO:0140252]; response to hypoxia [GO:0001666]; response to nitric oxide [GO:0071731]; ventricular septum morphogenesis [GO:0060412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; enzyme binding [GO:0019899]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545]; peptidyl-proline dioxygenase activity [GO:0031543]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; enzyme binding [GO:0019899]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545]; peptidyl-proline dioxygenase activity [GO:0031543]; cardiac muscle tissue morphogenesis [GO:0055008]; cellular response to hypoxia [GO:0071456]; heart trabecula formation [GO:0060347]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; labyrinthine layer development [GO:0060711]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of modification of postsynaptic structure [GO:0099159]; regulation protein catabolic process at postsynapse [GO:0140252]; response to hypoxia [GO:0001666]; response to nitric oxide [GO:0071731]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12615973, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}. Nucleus {ECO:0000269|PubMed:12615973, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}. Note=Mainly cytoplasmic. Shuttles between the nucleus and cytoplasm (PubMed:19631610). Nuclear export requires functional XPO1. {ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}.
Q9GZU1	reviewed	MCLN1_HUMAN	Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1)	MCOLN1 ML4 TRPML1 MSTP080	Homo sapiens (Human)	580	FUNCTION: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis (PubMed:11013137, PubMed:12459486, PubMed:15336987, PubMed:14749347, PubMed:29019983, PubMed:27623384). Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:15336987, PubMed:14749347, PubMed:25720963, PubMed:29019983, PubMed:27623384). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:25720963, PubMed:25733853, PubMed:27787197). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). {ECO:0000250|UniProtKB:Q99J21, ECO:0000269|PubMed:12459486, ECO:0000269|PubMed:14749347, ECO:0000269|PubMed:15336987, ECO:0000269|PubMed:16978393, ECO:0000269|PubMed:18794901, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:25733853, ECO:0000269|PubMed:27357649, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:27787197, ECO:0000269|PubMed:29019983, ECO:0000305|PubMed:11013137}.; FUNCTION: May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase. {ECO:0000305|PubMed:21256127}.		adaptive immune response [GO:0002250]; autophagosome maturation [GO:0097352]; calcium ion export [GO:1901660]; calcium ion transmembrane transport [GO:0070588]; cellular response to calcium ion [GO:0071277]; cellular response to pH [GO:0071467]; localization [GO:0051179]; monoatomic cation transport [GO:0006812]; phagosome maturation [GO:0090382]; positive regulation of lysosome organization [GO:1905673]; protein homotetramerization [GO:0051289]; transferrin transport [GO:0033572]	cell projection [GO:0042995]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity [GO:0097682]; iron ion transmembrane transporter activity [GO:0005381]; ligand-gated calcium channel activity [GO:0099604]; lipid binding [GO:0008289]; monoatomic cation channel activity [GO:0005261]; NAADP-sensitive calcium-release channel activity [GO:0072345]	cell projection [GO:0042995]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity [GO:0097682]; iron ion transmembrane transporter activity [GO:0005381]; ligand-gated calcium channel activity [GO:0099604]; lipid binding [GO:0008289]; monoatomic cation channel activity [GO:0005261]; NAADP-sensitive calcium-release channel activity [GO:0072345]; adaptive immune response [GO:0002250]; autophagosome maturation [GO:0097352]; calcium ion export [GO:1901660]; calcium ion transmembrane transport [GO:0070588]; cellular response to calcium ion [GO:0071277]; cellular response to pH [GO:0071467]; localization [GO:0051179]; monoatomic cation transport [GO:0006812]; phagosome maturation [GO:0090382]; positive regulation of lysosome organization [GO:1905673]; protein homotetramerization [GO:0051289]; transferrin transport [GO:0033572]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:15178326, ECO:0000269|PubMed:21224396}; Multi-pass membrane protein {ECO:0000269|PubMed:29019983}. Lysosome membrane {ECO:0000269|PubMed:12459486, ECO:0000269|PubMed:21224396, ECO:0000269|PubMed:25733853, ECO:0000305|PubMed:16497227, ECO:0000305|PubMed:16978393}; Multi-pass membrane protein {ECO:0000269|PubMed:29019983}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12459486}; Multi-pass membrane protein {ECO:0000269|PubMed:29019983}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q99J21}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q99J21}; Multi-pass membrane protein {ECO:0000269|PubMed:29019983}. Cell membrane {ECO:0000305|PubMed:29019983}; Multi-pass membrane protein {ECO:0000269|PubMed:29019983}. Note=Delivery from the trans-Golgi to lysosomes seems to occur mainly in a direct intracellular manner without intermediate delivery to the plasma membrane (PubMed:16497227). Under normal conditions, restricted to intracellular compartments so that only a very minor proportion is present at the cell membrane (PubMed:12459486, PubMed:18794901, PubMed:28112729, PubMed:29019983). {ECO:0000269|PubMed:12459486, ECO:0000269|PubMed:18794901, ECO:0000269|PubMed:28112729, ECO:0000269|PubMed:29019983, ECO:0000305|PubMed:16497227}.
Q9GZU2	reviewed	PEG3_HUMAN	Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24)	PEG3 KIAA0287 ZSCAN24	Homo sapiens (Human)	1588	FUNCTION: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. {ECO:0000250, ECO:0000269|PubMed:11260267}.		apoptotic process [GO:0006915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]	autophagosome [GO:0005776]; nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	autophagosome [GO:0005776]; nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; apoptotic process [GO:0006915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}. Cytoplasm {ECO:0000250}.
Q9GZU5	reviewed	NYX_HUMAN	Nyctalopin	NYX CLRP	Homo sapiens (Human)	481			response to stimulus [GO:0050896]; visual perception [GO:0007601]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q9GZU7	reviewed	CTDS1_HUMAN	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 3) (NLI-IF) (NLI-interacting factor 3) (Small C-terminal domain phosphatase 1) (SCP1) (Small CTD phosphatase 1)	CTDSP1 NIF3 NLIIF SCP1	Homo sapiens (Human)	261	FUNCTION: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}.		negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein phosphorylation [GO:0001933]; protein dephosphorylation [GO:0006470]; regulation of transcription by RNA polymerase II [GO:0006357]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein phosphorylation [GO:0001933]; protein dephosphorylation [GO:0006470]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12721286}. Note=Colocalizes with RNA polymerase II.
Q9GZU8	reviewed	PIP30_HUMAN	PSME3-interacting protein (NEFA-interacting nuclear protein NIP30) (PA28G-interacting protein)	PSME3IP1 C16orf94 FAM192A NIP30 PIP30 CDA018 CDA10	Homo sapiens (Human)	254	FUNCTION: Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus. {ECO:0000269|PubMed:29934401}.		negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein binding [GO:0032091]	intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein binding [GO:0032091]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29934401}.
Q9GZV1	reviewed	ANKR2_HUMAN	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp)	ANKRD2 ARPP	Homo sapiens (Human)	360	FUNCTION: Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. {ECO:0000269|PubMed:21737686, ECO:0000269|PubMed:22016770}.		muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619]	cytosol [GO:0005829]; euchromatin [GO:0000791]; I band [GO:0031674]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; PML body [GO:0016605]	protein kinase B binding [GO:0043422]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; structural constituent of muscle [GO:0008307]	cytosol [GO:0005829]; euchromatin [GO:0000791]; I band [GO:0031674]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; PML body [GO:0016605]; protein kinase B binding [GO:0043422]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; structural constituent of muscle [GO:0008307]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.
Q9GZV3	reviewed	SC5A7_HUMAN	High affinity choline transporter 1 (hCHT1) (Hemicholinium-3-sensitive choline transporter) (CHT) (Solute carrier family 5 member 7)	SLC5A7 CHT1	Homo sapiens (Human)	580	FUNCTION: High-affinity Na(+)-coupled choline transmembrane symporter (PubMed:11027560, PubMed:11068039, PubMed:12969261, PubMed:17005849, PubMed:23141292, PubMed:23132865, PubMed:12237312, PubMed:27569547). Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry (PubMed:17005849). Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion (PubMed:11068039, PubMed:17005849, PubMed:12237312). Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release (PubMed:27569547). SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials (PubMed:11027560). Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity (PubMed:12969261, PubMed:15953352). {ECO:0000269|PubMed:11027560, ECO:0000269|PubMed:11068039, ECO:0000269|PubMed:12237312, ECO:0000269|PubMed:12969261, ECO:0000269|PubMed:15953352, ECO:0000269|PubMed:17005849, ECO:0000269|PubMed:23132865, ECO:0000269|PubMed:23141292, ECO:0000269|PubMed:27569547}.		acetylcholine biosynthetic process [GO:0008292]; choline transport [GO:0015871]; in utero embryonic development [GO:0001701]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter transport [GO:0006836]; synaptic transmission, cholinergic [GO:0007271]; transmembrane transport [GO:0055085]	axon [GO:0030424]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]	choline binding [GO:0033265]; choline transmembrane transporter activity [GO:0015220]; choline:sodium symporter activity [GO:0005307]	axon [GO:0030424]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]; choline binding [GO:0033265]; choline transmembrane transporter activity [GO:0015220]; choline:sodium symporter activity [GO:0005307]; acetylcholine biosynthetic process [GO:0008292]; choline transport [GO:0015871]; in utero embryonic development [GO:0001701]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter transport [GO:0006836]; synaptic transmission, cholinergic [GO:0007271]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000269|PubMed:11027560, ECO:0000269|PubMed:12969261, ECO:0000269|PubMed:27569547}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BGY9}. Early endosome membrane {ECO:0000269|PubMed:12969261, ECO:0000269|PubMed:15953352}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:12969261}; Multi-pass membrane protein {ECO:0000305}. Note=Localized at the neuromuscular junction (PubMed:27569547). Localization at the plasma membrane is transient due to the rapid endocytosis of SLC5A7/CHT1 via the clathrin-mediated pathway, where it localizes to early endosomes (PubMed:12969261, PubMed:15953352). Also localized to synaptic vesicles where it is likely mobilized to the cell surface by exocytosis (PubMed:12969261). {ECO:0000269|PubMed:12969261, ECO:0000269|PubMed:15953352, ECO:0000269|PubMed:27569547}.
Q9GZV4	reviewed	IF5A2_HUMAN	Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2)	EIF5A2	Homo sapiens (Human)	153	FUNCTION: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:14622290). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241, ECO:0000269|PubMed:14622290}.		positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; spermatogenesis [GO:0007283]; translational elongation [GO:0006414]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; spermatogenesis [GO:0007283]; translational elongation [GO:0006414]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P63241}. Nucleus {ECO:0000250|UniProtKB:P63241}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P63241}; Peripheral membrane protein {ECO:0000250|UniProtKB:P63241}; Cytoplasmic side {ECO:0000250|UniProtKB:P63241}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250|UniProtKB:P63241}.
Q9GZV5	reviewed	WWTR1_HUMAN	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)	WWTR1 TAZ	Homo sapiens (Human)	400	FUNCTION: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321}.		cilium assembly [GO:0060271]; glomerulus development [GO:0032835]; heart process [GO:0003015]; hippo signaling [GO:0035329]; kidney morphogenesis [GO:0060993]; mesenchymal cell differentiation [GO:0048762]; multicellular organism growth [GO:0035264]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of DNA-templated transcription [GO:0006355]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of SMAD protein signal transduction [GO:0060390]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; stem cell division [GO:0017145]; tissue homeostasis [GO:0001894]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]	protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; cilium assembly [GO:0060271]; glomerulus development [GO:0032835]; heart process [GO:0003015]; hippo signaling [GO:0035329]; kidney morphogenesis [GO:0060993]; mesenchymal cell differentiation [GO:0048762]; multicellular organism growth [GO:0035264]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of DNA-templated transcription [GO:0006355]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of SMAD protein signal transduction [GO:0060390]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; stem cell division [GO:0017145]; tissue homeostasis [GO:0001894]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:25849865}. Cytoplasm {ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:25849865}. Cell membrane {ECO:0000269|PubMed:11118213}. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (By similarity). When phosphorylated, is retained in the cytoplasm by YWHAZ (By similarity). Can be retained in the nucleus by MED15 (PubMed:18568018). Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499). At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (By similarity). {ECO:0000250|UniProtKB:Q9EPK5, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:21145499}.
Q9GZV7	reviewed	HPLN2_HUMAN	Hyaluronan and proteoglycan link protein 2 (Brain link protein 1)	HAPLN2 BRAL1	Homo sapiens (Human)	340	FUNCTION: Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity). {ECO:0000250|UniProtKB:Q9ESM3}.		cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; establishment of blood-nerve barrier [GO:0008065]; extracellular matrix assembly [GO:0085029]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; node of Ranvier [GO:0033268]; perineuronal net [GO:0072534]; synapse [GO:0045202]	hyaluronic acid binding [GO:0005540]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; node of Ranvier [GO:0033268]; perineuronal net [GO:0072534]; synapse [GO:0045202]; hyaluronic acid binding [GO:0005540]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; establishment of blood-nerve barrier [GO:0008065]; extracellular matrix assembly [GO:0085029]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9ESM3}.
Q9GZV8	reviewed	PRD14_HUMAN	PR domain zinc finger protein 14 (EC 2.1.1.-) (PR domain-containing protein 14)	PRDM14	Homo sapiens (Human)	571	FUNCTION: Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. {ECO:0000250|UniProtKB:E9Q3T6, ECO:0000269|PubMed:17942894, ECO:0000269|PubMed:20953172}.		cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; embryo implantation [GO:0007566]; fertilization [GO:0009566]; fibroblast growth factor receptor signaling pathway [GO:0008543]; germ cell development [GO:0007281]; germ-line stem cell population maintenance [GO:0030718]; homeostasis of number of cells within a tissue [GO:0048873]; inactivation of paternal X chromosome [GO:0060817]; inner cell mass cell fate commitment [GO:0001827]; methylation [GO:0032259]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of DNA methylation [GO:0044030]; regulation of transcription by RNA polymerase II [GO:0006357]	intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; embryo implantation [GO:0007566]; fertilization [GO:0009566]; fibroblast growth factor receptor signaling pathway [GO:0008543]; germ cell development [GO:0007281]; germ-line stem cell population maintenance [GO:0030718]; homeostasis of number of cells within a tissue [GO:0048873]; inactivation of paternal X chromosome [GO:0060817]; inner cell mass cell fate commitment [GO:0001827]; methylation [GO:0032259]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of DNA methylation [GO:0044030]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17942894}.
Q9GZV9	reviewed	FGF23_HUMAN	Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide]	FGF23 HYPF UNQ3027/PRO9828	Homo sapiens (Human)	251	FUNCTION: Regulator of phosphate homeostasis (PubMed:11062477). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (PubMed:11409890). Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (PubMed:15040831). Negatively regulates osteoblast differentiation and matrix mineralization (PubMed:18282132). {ECO:0000250|UniProtKB:Q8VI82, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}.		animal organ morphogenesis [GO:0009887]; calcium ion homeostasis [GO:0055074]; cell differentiation [GO:0030154]; cellular response to interleukin-6 [GO:0071354]; cellular response to leptin stimulus [GO:0044320]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to vitamin D [GO:0071305]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast growth factor receptor signaling pathway [GO:0008543]; intracellular phosphate ion homeostasis [GO:0030643]; negative regulation of bone mineralization [GO:0030502]; negative regulation of hormone secretion [GO:0046888]; negative regulation of osteoblast differentiation [GO:0045668]; phosphate ion homeostasis [GO:0055062]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vitamin D 24-hydroxylase activity [GO:0010980]; regulation of cell migration [GO:0030334]; regulation of phosphate transport [GO:0010966]; response to magnesium ion [GO:0032026]; response to sodium phosphate [GO:1904383]; vitamin D catabolic process [GO:0042369]	cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]	growth factor activity [GO:0008083]; type 1 fibroblast growth factor receptor binding [GO:0005105]	cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; growth factor activity [GO:0008083]; type 1 fibroblast growth factor receptor binding [GO:0005105]; animal organ morphogenesis [GO:0009887]; calcium ion homeostasis [GO:0055074]; cell differentiation [GO:0030154]; cellular response to interleukin-6 [GO:0071354]; cellular response to leptin stimulus [GO:0044320]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to vitamin D [GO:0071305]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast growth factor receptor signaling pathway [GO:0008543]; intracellular phosphate ion homeostasis [GO:0030643]; negative regulation of bone mineralization [GO:0030502]; negative regulation of hormone secretion [GO:0046888]; negative regulation of osteoblast differentiation [GO:0045668]; phosphate ion homeostasis [GO:0055062]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vitamin D 24-hydroxylase activity [GO:0010980]; regulation of cell migration [GO:0030334]; regulation of phosphate transport [GO:0010966]; response to magnesium ion [GO:0032026]; response to sodium phosphate [GO:1904383]; vitamin D catabolic process [GO:0042369]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16638743}. Note=Secretion is dependent on O-glycosylation.
Q9GZW8	reviewed	MS4A7_HUMAN	Membrane-spanning 4-domains subfamily A member 7 (CD20 antigen-like 4) (CD20/FC-epsilon-RI-beta family member 4) (Four-span transmembrane protein 2)	MS4A7 4SPAN2 CD20L4 CFFM4	Homo sapiens (Human)	240	FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex.		cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]		plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9GZX3	reviewed	CHST6_HUMAN	Carbohydrate sulfotransferase 6 (Corneal N-acetylglucosamine-6-O-sulfotransferase) (C-GlcNAc6ST) (hCGn6ST) (EC 2.8.2.21) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta) (GST4-beta) (N-acetylglucosamine 6-O-sulfotransferase 5) (GlcNAc6ST-5) (Gn6st-5)	CHST6	Homo sapiens (Human)	395	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan (PubMed:11352640, PubMed:11278593, PubMed:12218059, PubMed:17690104). Cooperates with B4GALT4 galactosyltransferase and B3GNT7 N-acetylglucosaminyltransferase to construct and elongate the sulfated disaccharide unit [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Involved in biosynthesis of keratan sulfate in cornea, with an impact on proteoglycan fibril organization and corneal transparency (PubMed:17690104, PubMed:11278593, PubMed:12218059). Involved in sulfation of endothelial mucins such as GLYCAM1 (PubMed:11352640). {ECO:0000269|PubMed:11278593, ECO:0000269|PubMed:11352640, ECO:0000269|PubMed:12218059, ECO:0000269|PubMed:17690104}.		carbohydrate metabolic process [GO:0005975]; keratan sulfate biosynthetic process [GO:0018146]; N-acetylglucosamine metabolic process [GO:0006044]; sulfur compound metabolic process [GO:0006790]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	keratan sulfotransferase activity [GO:0045130]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; keratan sulfotransferase activity [GO:0045130]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; carbohydrate metabolic process [GO:0005975]; keratan sulfate biosynthetic process [GO:0018146]; N-acetylglucosamine metabolic process [GO:0006044]; sulfur compound metabolic process [GO:0006790]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9GZX5	reviewed	ZN350_HUMAN	Zinc finger protein 350 (KRAB zinc finger protein ZFQR) (Zinc finger and BRCA1-interacting protein with a KRAB domain 1) (Zinc finger protein ZBRK1)	ZNF350 ZBRK1	Homo sapiens (Human)	532	FUNCTION: Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3. {ECO:0000269|PubMed:11090615}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]	nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus. Nucleus matrix. Note=Associated with the nuclear matrix.
Q9GZX6	reviewed	IL22_HUMAN	Interleukin-22 (IL-22) (Cytokine Zcyto18) (IL-10-related T-cell-derived-inducible factor) (IL-TIF)	IL22 ILTIF ZCYTO18 UNQ3099/PRO10096	Homo sapiens (Human)	179	FUNCTION: Cytokine that plays a critical role in modulating tissue responses during inflammation (PubMed:17204547). Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage (PubMed:17204547). Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB (PubMed:10875937, PubMed:18599299). Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways (PubMed:25793261, PubMed:31311100). Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN (By similarity). Promotes epithelial cell spreading (By similarity). {ECO:0000250|UniProtKB:Q9JJY9, ECO:0000269|PubMed:10875937, ECO:0000269|PubMed:17204547, ECO:0000269|PubMed:18599299, ECO:0000269|PubMed:25793261, ECO:0000269|PubMed:31311100}.		acute-phase response [GO:0006953]; inflammatory response [GO:0006954]; negative regulation of inflammatory response [GO:0050728]; response to glucocorticoid [GO:0051384]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; interleukin-22 receptor binding [GO:0045518]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; interleukin-22 receptor binding [GO:0045518]; acute-phase response [GO:0006953]; inflammatory response [GO:0006954]; negative regulation of inflammatory response [GO:0050728]; response to glucocorticoid [GO:0051384]	SUBCELLULAR LOCATION: Secreted.
Q9GZX7	reviewed	AICDA_HUMAN	Single-stranded DNA cytosine deaminase (EC 3.5.4.38) (Activation-induced cytidine deaminase) (AID) (Cytidine aminohydrolase)	AICDA AID	Homo sapiens (Human)	198	FUNCTION: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). {ECO:0000269|PubMed:18722174, ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21518874, ECO:0000269|PubMed:27716525}.		B cell differentiation [GO:0030183]; cellular response to lipopolysaccharide [GO:0071222]; cytidine to uridine editing [GO:0016554]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; isotype switching [GO:0045190]; mRNA processing [GO:0006397]; negative regulation of DNA methylation-dependent heterochromatin formation [GO:0090310]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; regulation of nuclear cell cycle DNA replication [GO:0033262]; somatic diversification of immunoglobulins [GO:0016445]; somatic hypermutation of immunoglobulin genes [GO:0016446]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]	cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; B cell differentiation [GO:0030183]; cellular response to lipopolysaccharide [GO:0071222]; cytidine to uridine editing [GO:0016554]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; isotype switching [GO:0045190]; mRNA processing [GO:0006397]; negative regulation of DNA methylation-dependent heterochromatin formation [GO:0090310]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; regulation of nuclear cell cycle DNA replication [GO:0033262]; somatic diversification of immunoglobulins [GO:0016445]; somatic hypermutation of immunoglobulin genes [GO:0016446]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:32484799}. Cytoplasm, cytosol {ECO:0000269|PubMed:18722174, ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:32484799}. Note=Predominantly cytosolic (PubMed:21385873). In the presence of MCM3AP/GANP, relocalizes to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9WVE0, ECO:0000269|PubMed:21385873}.
Q9GZX9	reviewed	TWSG1_HUMAN	Twisted gastrulation protein homolog 1	TWSG1 TSG PSEC0250	Homo sapiens (Human)	223	FUNCTION: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	BMP signaling pathway [GO:0030509]; camera-type eye development [GO:0043010]; chondrocyte differentiation [GO:0002062]; forebrain development [GO:0030900]; hemopoiesis [GO:0030097]; mesoderm formation [GO:0001707]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of CD4-positive, alpha-beta T cell activation [GO:2000515]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of cytokine production [GO:0001818]; negative regulation of osteoblast differentiation [GO:0045668]; ossification [GO:0001503]; positive regulation of BMP signaling pathway [GO:0030513]; regulation of BMP signaling pathway [GO:0030510]; salivary gland morphogenesis [GO:0007435]; transforming growth factor beta receptor signaling pathway [GO:0007179]	extracellular space [GO:0005615]	heparin binding [GO:0008201]; transforming growth factor beta binding [GO:0050431]	extracellular space [GO:0005615]; heparin binding [GO:0008201]; transforming growth factor beta binding [GO:0050431]; BMP signaling pathway [GO:0030509]; camera-type eye development [GO:0043010]; chondrocyte differentiation [GO:0002062]; forebrain development [GO:0030900]; hemopoiesis [GO:0030097]; mesoderm formation [GO:0001707]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of CD4-positive, alpha-beta T cell activation [GO:2000515]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of cytokine production [GO:0001818]; negative regulation of osteoblast differentiation [GO:0045668]; ossification [GO:0001503]; positive regulation of BMP signaling pathway [GO:0030513]; regulation of BMP signaling pathway [GO:0030510]; salivary gland morphogenesis [GO:0007435]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q9GZY0	reviewed	NXF2_HUMAN	Nuclear RNA export factor 2 (Cancer/testis antigen 39) (CT39) (TAP-like protein 2) (TAPL-2)	NXF2 TAPL2; NXF2B	Homo sapiens (Human)	626	FUNCTION: Involved in the export of mRNA from the nucleus to the cytoplasm.		mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA transport [GO:0050658]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA transport [GO:0050658]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in the nucleoplasm and at the nuclear envelope. Shuttles between the nucleus and the cytoplasm.
Q9GZY6	reviewed	NTAL_HUMAN	Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein)	LAT2 LAB NTAL WBS15 WBSCR15 WBSCR5 HSPC046	Homo sapiens (Human)	243	FUNCTION: Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}.		adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; B cell receptor signaling pathway [GO:0050853]; calcium-mediated signaling [GO:0019722]; intracellular signal transduction [GO:0035556]; mast cell degranulation [GO:0043303]	extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	SH2 domain binding [GO:0042169]	extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; SH2 domain binding [GO:0042169]; adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; B cell receptor signaling pathway [GO:0050853]; calcium-mediated signaling [GO:0019722]; intracellular signal transduction [GO:0035556]; mast cell degranulation [GO:0043303]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734}; Single-pass type III membrane protein {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734}. Note=Present in lipid rafts.
Q9GZY8	reviewed	MFF_HUMAN	Mitochondrial fission factor	MFF C2orf33 AD030 AD033 GL004	Homo sapiens (Human)	342	FUNCTION: Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}.		mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; mitochondrion morphogenesis [GO:0070584]; peroxisome fission [GO:0016559]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein targeting to mitochondrion [GO:0006626]; regulation of mitochondrion organization [GO:0010821]; regulation of peroxisome organization [GO:1900063]; release of cytochrome c from mitochondria [GO:0001836]	mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; synaptic vesicle [GO:0008021]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; synaptic vesicle [GO:0008021]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; mitochondrion morphogenesis [GO:0070584]; peroxisome fission [GO:0016559]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein targeting to mitochondrion [GO:0006626]; regulation of mitochondrion organization [GO:0010821]; regulation of peroxisome organization [GO:1900063]; release of cytochrome c from mitochondria [GO:0001836]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23921378}; Single-pass type IV membrane protein {ECO:0000255}. Peroxisome {ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23921378}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q4KM98}.
Q9GZZ1	reviewed	NAA50_HUMAN	N-alpha-acetyltransferase 50 (hNaa50p) (EC 2.3.1.258) (N-acetyltransferase 13) (N-acetyltransferase 5) (hNAT5) (N-acetyltransferase san homolog) (hSAN) (N-epsilon-acetyltransferase 50) (EC 2.3.1.-) (NatE catalytic subunit)	NAA50 MAK3 NAT13 NAT5	Homo sapiens (Human)	169	FUNCTION: N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed:19744929, PubMed:22311970, PubMed:21900231, PubMed:27484799). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (PubMed:27484799). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (PubMed:19744929). Autoacetylates in vivo (PubMed:19744929). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (PubMed:19744929). Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity (PubMed:16507339, PubMed:29754825, PubMed:27484799, PubMed:32042062). Does not influence the acetyltransferase activity of NAA10 (PubMed:16507339, PubMed:27484799). However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex) (PubMed:32042062). The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (PubMed:16507339, PubMed:27484799). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (PubMed:17502424, PubMed:27422821). {ECO:0000269|PubMed:16507339, ECO:0000269|PubMed:17502424, ECO:0000269|PubMed:19744929, ECO:0000269|PubMed:21900231, ECO:0000269|PubMed:22311970, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27484799, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}.		establishment of mitotic sister chromatid cohesion [GO:0034087]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid cohesion, centromeric [GO:0071962]; N-terminal protein amino acid acetylation [GO:0006474]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; NatA complex [GO:0031415]; nucleolus [GO:0005730]; nucleus [GO:0005634]	histone H4 acetyltransferase activity [GO:0010485]; peptide alpha-N-acetyltransferase activity [GO:0004596]; peptidyl-lysine acetyltransferase activity [GO:0052858]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; NatA complex [GO:0031415]; nucleolus [GO:0005730]; nucleus [GO:0005634]; histone H4 acetyltransferase activity [GO:0010485]; peptide alpha-N-acetyltransferase activity [GO:0004596]; peptidyl-lysine acetyltransferase activity [GO:0052858]; establishment of mitotic sister chromatid cohesion [GO:0034087]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid cohesion, centromeric [GO:0071962]; N-terminal protein amino acid acetylation [GO:0006474]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16507339, ECO:0000269|PubMed:17502424, ECO:0000269|PubMed:25732826, ECO:0000269|PubMed:27422821}. Nucleus {ECO:0000269|PubMed:25732826}. Note=Localizes to the cytoplasm in interphase cells (PubMed:17502424). {ECO:0000269|PubMed:17502424}.
Q9GZZ6	reviewed	ACH10_HUMAN	Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)	CHRNA10 NACHRA10	Homo sapiens (Human)	450	FUNCTION: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. {ECO:0000269|PubMed:11752216}.	MISCELLANEOUS: The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).	detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; membrane depolarization [GO:0051899]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cell population proliferation [GO:0042127]; response to auditory stimulus [GO:0010996]; synaptic transmission, cholinergic [GO:0007271]	axon [GO:0030424]; cholinergic synapse [GO:0098981]; membrane [GO:0016020]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; calcium channel activity [GO:0005262]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]	axon [GO:0030424]; cholinergic synapse [GO:0098981]; membrane [GO:0016020]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; calcium channel activity [GO:0005262]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; membrane depolarization [GO:0051899]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cell population proliferation [GO:0042127]; response to auditory stimulus [GO:0010996]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9GZZ7	reviewed	GFRA4_HUMAN	GDNF family receptor alpha-4 (GDNF receptor alpha-4) (GDNFR-alpha-4) (GFR-alpha-4) (Persephin receptor)	GFRA4	Homo sapiens (Human)	299	FUNCTION: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.		negative regulation of ossification [GO:0030279]; nervous system development [GO:0007399]; ossification [GO:0001503]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	glial cell-derived neurotrophic factor receptor activity [GO:0016167]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; glial cell-derived neurotrophic factor receptor activity [GO:0016167]; negative regulation of ossification [GO:0030279]; nervous system development [GO:0007399]; ossification [GO:0001503]	SUBCELLULAR LOCATION: [Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform GFRalpha4c]: Secreted.
Q9GZZ8	reviewed	LACRT_HUMAN	Extracellular glycoprotein lacritin	LACRT	Homo sapiens (Human)	138	FUNCTION: Modulates secretion by lacrimal acinar cells.		calcineurin-NFAT signaling cascade [GO:0033173]; calcium-mediated signaling [GO:0019722]; defense response to bacterium [GO:0042742]; epithelial structure maintenance [GO:0010669]; negative regulation of apoptotic process [GO:0043066]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of macroautophagy [GO:0016239]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of secretion [GO:0051047]; protein acetylation [GO:0006473]; protein localization to Golgi apparatus [GO:0034067]; tear secretion [GO:0070075]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]	collagen binding [GO:0005518]; growth factor activity [GO:0008083]; laminin-1 binding [GO:0043237]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; collagen binding [GO:0005518]; growth factor activity [GO:0008083]; laminin-1 binding [GO:0043237]; calcineurin-NFAT signaling cascade [GO:0033173]; calcium-mediated signaling [GO:0019722]; defense response to bacterium [GO:0042742]; epithelial structure maintenance [GO:0010669]; negative regulation of apoptotic process [GO:0043066]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of macroautophagy [GO:0016239]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of secretion [GO:0051047]; protein acetylation [GO:0006473]; protein localization to Golgi apparatus [GO:0034067]; tear secretion [GO:0070075]	SUBCELLULAR LOCATION: Secreted.
Q9GZZ9	reviewed	UBA5_HUMAN	Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1)	UBA5 UBE1DC1	Homo sapiens (Human)	404	FUNCTION: E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:25219498, PubMed:20368332, PubMed:27653677, PubMed:26929408, PubMed:27545674, PubMed:30412706, PubMed:27545681). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:27653677, PubMed:26929408, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677). Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:32160526). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VE47, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29295865, ECO:0000269|PubMed:30412706, ECO:0000269|PubMed:32160526}.		erythrocyte differentiation [GO:0030218]; localization [GO:0051179]; megakaryocyte differentiation [GO:0030219]; neuromuscular process [GO:0050905]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]; selective autophagy [GO:0061912]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]	ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; UFM1 activating enzyme activity [GO:0071566]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; UFM1 activating enzyme activity [GO:0071566]; zinc ion binding [GO:0008270]; erythrocyte differentiation [GO:0030218]; localization [GO:0051179]; megakaryocyte differentiation [GO:0030219]; neuromuscular process [GO:0050905]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]; selective autophagy [GO:0061912]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:26872069}. Nucleus {ECO:0000269|PubMed:18442052}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30990354}. Golgi apparatus {ECO:0000269|PubMed:26872069}. Note=Localizes mainly in the cytoplasm, while it localizes to the nucleus in presence of SUMO2 (PubMed:18442052). Interaction with GABARAPL2 promotes localization to the endoplasmic reticulum membrane (PubMed:30990354). {ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:30990354}.
Q9H000	reviewed	MKRN2_HUMAN	E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2)	MKRN2 RNF62 HSPC070	Homo sapiens (Human)	416	FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity). {ECO:0000250|UniProtKB:Q9ERV1}.	MISCELLANEOUS: Partially overlaps and is antisense to the RAF1 proto-oncogene.	cell differentiation [GO:0030154]; DNA-templated transcription [GO:0006351]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; cell differentiation [GO:0030154]; DNA-templated transcription [GO:0006351]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ERV1}. Nucleus {ECO:0000250|UniProtKB:Q9ERV1}.
Q9H008	reviewed	LHPP_HUMAN	Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (hLHPP) (EC 3.1.3.-) (EC 3.6.1.1)	LHPP	Homo sapiens (Human)	270	FUNCTION: Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). {ECO:0000250}.		dephosphorylation [GO:0016311]; phosphate-containing compound metabolic process [GO:0006796]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	inorganic diphosphate phosphatase activity [GO:0004427]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; inorganic diphosphate phosphatase activity [GO:0004427]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; dephosphorylation [GO:0016311]; phosphate-containing compound metabolic process [GO:0006796]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16430861}. Nucleus {ECO:0000269|PubMed:16430861}.
Q9H013	reviewed	ADA19_HUMAN	Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (EC 3.4.24.-) (Meltrin-beta) (Metalloprotease and disintegrin dendritic antigen marker) (MADDAM)	ADAM19 MLTNB FKSG34	Homo sapiens (Human)	955	FUNCTION: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). {ECO:0000250}.		amyloid precursor protein catabolic process [GO:0042987]; membrane protein ectodomain proteolysis [GO:0006509]; placenta development [GO:0001890]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of gene expression [GO:0010628]; protein processing [GO:0016485]	collagen-containing extracellular matrix [GO:0062023]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; SH3 domain binding [GO:0017124]	collagen-containing extracellular matrix [GO:0062023]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; SH3 domain binding [GO:0017124]; amyloid precursor protein catabolic process [GO:0042987]; membrane protein ectodomain proteolysis [GO:0006509]; placenta development [GO:0001890]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of gene expression [GO:0010628]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9H015	reviewed	S22A4_HUMAN	Solute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (ETTh) (Organic cation/carnitine transporter 1) (OCTN1)	SLC22A4 ETT OCTN1 UT2H	Homo sapiens (Human)	551	FUNCTION: Transporter that mediates the transport of endogenous and microbial zwitterions and organic cations (PubMed:15795384, PubMed:10215651, PubMed:16729965, PubMed:20601551, PubMed:22569296, PubMed:29530864, PubMed:15107849, PubMed:22206629). Functions as a Na(+)-dependent and pH-dependent high affinity microbial symporter of potent food-derived antioxidant ergothioeine (PubMed:15795384, PubMed:29530864, PubMed:33124720). Transports one sodium ion with one ergothioeine molecule (By similarity). Involved in the absorption of ergothioneine from the luminal/apical side of the small intestine and renal tubular cells, and into non-parenchymal liver cells, thereby contributing to maintain steady-state ergothioneine level in the body (PubMed:20601551). Also mediates the bidirectional transport of acetycholine, although the exact transport mechanism has not been fully identified yet (PubMed:22206629). Most likely exports anti-inflammatory acetylcholine in non-neuronal tissues, thereby contributing to the non-neuronal cholinergic system (PubMed:22569296, PubMed:22206629). Displays a general physiological role linked to better survival by controlling inflammation and oxidative stress, which may be related to ergothioneine and acetycholine transports (PubMed:15795384, PubMed:22206629). May also function as a low-affinity Na(+)-dependent transporter of L-carnitine through the mitochondrial membrane, thereby maintaining intracellular carnitine homeostasis (PubMed:10215651, PubMed:16729965, PubMed:15107849). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (PubMed:35307651). {ECO:0000250|UniProtKB:Q9R141, ECO:0000269|PubMed:10215651, ECO:0000269|PubMed:15107849, ECO:0000269|PubMed:15795384, ECO:0000269|PubMed:16729965, ECO:0000269|PubMed:20601551, ECO:0000269|PubMed:22206629, ECO:0000269|PubMed:22569296, ECO:0000269|PubMed:29530864, ECO:0000269|PubMed:35307651}.	MISCELLANEOUS: Mediates the Na(+)-independent and pH-dependent bidirectional transport of exogenous prototype organic cation tetraethylammonium (TEA). {ECO:0000269|PubMed:10215651, ECO:0000269|PubMed:15107849, ECO:0000269|PubMed:15459889, ECO:0000269|PubMed:15832501, ECO:0000269|PubMed:9426230}.	amino acid import across plasma membrane [GO:0089718]; carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879]; quaternary ammonium group transport [GO:0015697]; sodium ion transport [GO:0006814]; triglyceride metabolic process [GO:0006641]; xenobiotic transport [GO:0042908]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	acetylcholine transmembrane transporter activity [GO:0005277]; amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; secondary active organic cation transmembrane transporter activity [GO:0008513]; symporter activity [GO:0015293]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; acetylcholine transmembrane transporter activity [GO:0005277]; amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; secondary active organic cation transmembrane transporter activity [GO:0008513]; symporter activity [GO:0015293]; amino acid import across plasma membrane [GO:0089718]; carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879]; quaternary ammonium group transport [GO:0015697]; sodium ion transport [GO:0006814]; triglyceride metabolic process [GO:0006641]; xenobiotic transport [GO:0042908]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:20601551}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000269|PubMed:16729965}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the apical membrane of small intestines (PubMed:20601551). Localized to the basal membrane of Sertoli cells (PubMed:35307651). {ECO:0000269|PubMed:20601551, ECO:0000269|PubMed:35307651}.
Q9H040	reviewed	SPRTN_HUMAN	DNA-dependent metalloprotease SPRTN (EC 3.4.24.-) (DNA damage protein targeting VCP) (DVC1) (Protein with SprT-like domain at the N terminus) (Spartan)	SPRTN C1orf124 DVC1 UNQ1880/PRO4323	Homo sapiens (Human)	489	FUNCTION: DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:27852435, PubMed:27871366, PubMed:27871365, PubMed:32649882, PubMed:30893605). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:27852435, PubMed:27871366, PubMed:27871365, PubMed:32649882). Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis (PubMed:27852435, PubMed:27871366, PubMed:27871365, PubMed:32649882). Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4 (PubMed:27871366). Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs (By similarity). SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity). Involved in recruitment of VCP/p97 to sites of DNA damage (PubMed:22902628, PubMed:23042605, PubMed:23042607, PubMed:32152270). Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation (PubMed:31316063). Does not activate CHEK1 in response to DNA damage (PubMed:31316063). May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA (PubMed:22681887, PubMed:22894931, PubMed:22902628, PubMed:22987070). Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis (PubMed:22681887). {ECO:0000250|UniProtKB:A0A1L8G2K9, ECO:0000269|PubMed:22681887, ECO:0000269|PubMed:22894931, ECO:0000269|PubMed:22902628, ECO:0000269|PubMed:22987070, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:27852435, ECO:0000269|PubMed:27871365, ECO:0000269|PubMed:27871366, ECO:0000269|PubMed:30893605, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:32649882}.		DNA damage response [GO:0006974]; positive regulation of protein ubiquitination [GO:0031398]; protein autoprocessing [GO:0016540]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	double-stranded DNA binding [GO:0003690]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; polyubiquitin modification-dependent protein binding [GO:0031593]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; double-stranded DNA binding [GO:0003690]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; polyubiquitin modification-dependent protein binding [GO:0031593]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130]; DNA damage response [GO:0006974]; positive regulation of protein ubiquitination [GO:0031398]; protein autoprocessing [GO:0016540]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22681887, ECO:0000269|PubMed:22894931, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:27852435}. Chromosome {ECO:0000269|PubMed:22894931, ECO:0000269|PubMed:22902628, ECO:0000269|PubMed:22987070, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:27852435, ECO:0000269|PubMed:27871365, ECO:0000269|PubMed:27871366, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32649882}. Note=Localizes to sites of UV damage via the PIP-box (PubMed:22894931, PubMed:23042605). Recruited to stalled replication forks at sites of replication stress following deubiquitination (PubMed:22894931, PubMed:23042605, PubMed:22987070, PubMed:27871365, PubMed:32649882). CHEK1 stimulates recruitment to chromatin (PubMed:31316063). {ECO:0000269|PubMed:22894931, ECO:0000269|PubMed:22987070, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:27871365, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32649882}.
Q9H063	reviewed	MAF1_HUMAN	Repressor of RNA polymerase III transcription MAF1 homolog	MAF1	Homo sapiens (Human)	256	FUNCTION: Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:20887893, PubMed:17505538). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043). {ECO:0000250|UniProtKB:Q9D0U6, ECO:0000269|PubMed:17499043, ECO:0000269|PubMed:17505538, ECO:0000269|PubMed:18377933, ECO:0000269|PubMed:20233713, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20543138, ECO:0000269|PubMed:20887893, ECO:0000269|PubMed:26941251}.		negative regulation of transcription by RNA polymerase I [GO:0016479]; negative regulation of transcription by RNA polymerase III [GO:0016480]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA polymerase III core binding [GO:0000994]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III core binding [GO:0000994]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; negative regulation of transcription by RNA polymerase I [GO:0016479]; negative regulation of transcription by RNA polymerase III [GO:0016480]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17505538, ECO:0000269|PubMed:20233713}. Cytoplasm {ECO:0000269|PubMed:20233713}.
Q9H074	reviewed	PAIP1_HUMAN	Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1)	PAIP1	Homo sapiens (Human)	479	FUNCTION: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:9548260}.; FUNCTION: (Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis. {ECO:0000269|PubMed:33876849}.		CRD-mediated mRNA stabilization [GO:0070934]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; positive regulation by host of viral process [GO:0044794]; positive regulation of cytoplasmic translation [GO:2000767]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral translation [GO:0019081]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mCRD-mediated mRNA stability complex [GO:0106002]	RNA binding [GO:0003723]; translation activator activity [GO:0008494]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mCRD-mediated mRNA stability complex [GO:0106002]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; positive regulation by host of viral process [GO:0044794]; positive regulation of cytoplasmic translation [GO:2000767]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral translation [GO:0019081]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q9H078	reviewed	CLPB_HUMAN	Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form]	CLPB SKD3	Homo sapiens (Human)	707	FUNCTION: Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins (PubMed:32573439, PubMed:34115842, PubMed:35247700, PubMed:36170828, PubMed:36745679). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). Plays a role in granulocyte differentiation (PubMed:34115842). {ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:32573439, ECO:0000269|PubMed:34115842, ECO:0000269|PubMed:35247700, ECO:0000269|PubMed:36170828, ECO:0000269|PubMed:36745679}.	MISCELLANEOUS: Hexamers display robustness and can tolerate some mutant subunits without loss of activity (PubMed:36170828). Subunits containing SCN9-linked variants Lys-496, Gly-561 and Cys-620 inhibit ATPase and disaggregase activities of the hexamer more severely than those containing MGCA7-linked variants Gly-408, Gly-475 and Val-591 (PubMed:36170828). {ECO:0000269|PubMed:36170828}.	antiviral innate immune response [GO:0140374]; cellular response to heat [GO:0034605]; granulocyte differentiation [GO:0030851]; RIG-I signaling pathway [GO:0039529]	cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]	cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; antiviral innate immune response [GO:0140374]; cellular response to heat [GO:0034605]; granulocyte differentiation [GO:0030851]; RIG-I signaling pathway [GO:0039529]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:25597510, ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:32866687, ECO:0000269|PubMed:34115842}.
Q9H079	reviewed	KTBL1_HUMAN	KATNB1-like protein 1 (Katanin p80 subunit B-like 1)	KATNBL1 C15orf29	Homo sapiens (Human)	304	FUNCTION: Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro. {ECO:0000269|PubMed:26929214}.		cytoplasmic microtubule organization [GO:0031122]; positive regulation of cytoskeleton organization [GO:0051495]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; katanin complex [GO:0008352]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	microtubule binding [GO:0008017]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; katanin complex [GO:0008352]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; microtubule binding [GO:0008017]; cytoplasmic microtubule organization [GO:0031122]; positive regulation of cytoskeleton organization [GO:0051495]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26929214}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:26929214}. Note=Localizes to the spindle poles only during mitosis. Sequestered to the nucleus during interphase. {ECO:0000269|PubMed:26929214}.
Q9H081	reviewed	MIS12_HUMAN	Protein MIS12 homolog	MIS12	Homo sapiens (Human)	205	FUNCTION: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108). {ECO:0000269|PubMed:12515822, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270, ECO:0000269|PubMed:23891108}.		attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic sister chromatid segregation [GO:0000070]	cytosol [GO:0005829]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nucleus [GO:0005634]; spindle pole [GO:0000922]		cytosol [GO:0005829]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nucleus [GO:0005634]; spindle pole [GO:0000922]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic sister chromatid segregation [GO:0000070]	SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12515822, ECO:0000269|PubMed:15502821}. Note=Associated with the kinetochore. {ECO:0000269|PubMed:12515822, ECO:0000269|PubMed:15502821}.
Q9H082	reviewed	RB33B_HUMAN	Ras-related protein Rab-33B	RAB33B	Homo sapiens (Human)	229	FUNCTION: Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation. {ECO:0000269|PubMed:20163571}.		autophagosome assembly [GO:0000045]; intra-Golgi vesicle-mediated transport [GO:0006891]; negative regulation of constitutive secretory pathway [GO:1903434]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]; regulation of Golgi organization [GO:1903358]; regulation of retrograde vesicle-mediated transport, Golgi to ER [GO:2000156]; skeletal system morphogenesis [GO:0048705]	endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; presynapse [GO:0098793]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; presynapse [GO:0098793]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagosome assembly [GO:0000045]; intra-Golgi vesicle-mediated transport [GO:0006891]; negative regulation of constitutive secretory pathway [GO:1903434]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]; regulation of Golgi organization [GO:1903358]; regulation of retrograde vesicle-mediated transport, Golgi to ER [GO:2000156]; skeletal system morphogenesis [GO:0048705]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:O35963}; Lipid-anchor {ECO:0000305}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:18448665}. Note=Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm. {ECO:0000250|UniProtKB:O35963}.
Q9H089	reviewed	LSG1_HUMAN	Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.1.-)	LSG1	Homo sapiens (Human)	658	FUNCTION: GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable). {ECO:0000305|PubMed:16209721}.		nuclear export [GO:0051168]; protein transport [GO:0015031]; ribosomal subunit export from nucleus [GO:0000054]	Cajal body [GO:0015030]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Cajal body [GO:0015030]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; nuclear export [GO:0051168]; protein transport [GO:0015031]; ribosomal subunit export from nucleus [GO:0000054]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16209721}. Endoplasmic reticulum {ECO:0000269|PubMed:16209721}. Nucleus, Cajal body {ECO:0000269|PubMed:16209721}. Note=Shuttles between the Cajal bodies in the nucleus and the endoplasmic reticulum.
Q9H093	reviewed	NUAK2_HUMAN	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK)	NUAK2 OMPHK2 SNARK	Homo sapiens (Human)	628	FUNCTION: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}.		actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; cellular response to glucose starvation [GO:0042149]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of TOR signaling [GO:0032007]; protein localization to nucleus [GO:0034504]; protein phosphorylation [GO:0006468]; regulation of hippo signaling [GO:0035330]	nucleotide-activated protein kinase complex [GO:0031588]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	nucleotide-activated protein kinase complex [GO:0031588]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; cellular response to glucose starvation [GO:0042149]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of TOR signaling [GO:0032007]; protein localization to nucleus [GO:0034504]; protein phosphorylation [GO:0006468]; regulation of hippo signaling [GO:0035330]	
Q9H095	reviewed	DRC9_HUMAN	Dynein regulatory complex protein 9 (IQ domain-containing protein G)	IQCG DRC9	Homo sapiens (Human)	443	FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. {ECO:0000250|UniProtKB:A3KQH2, ECO:0000250|UniProtKB:A8HQ54, ECO:0000250|UniProtKB:Q80W32}.		cilium organization [GO:0044782]; sperm axoneme assembly [GO:0007288]; spermatid development [GO:0007286]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; manchette [GO:0002177]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]	calmodulin binding [GO:0005516]; Hsp70 protein binding [GO:0030544]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; manchette [GO:0002177]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]; calmodulin binding [GO:0005516]; Hsp70 protein binding [GO:0030544]; cilium organization [GO:0044782]; sperm axoneme assembly [GO:0007288]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24787902}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q80W32}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80W32}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q80W32}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8HQ54}. Note=First detected in the cytoplasm of pachytene spermatocytes. Colocalizes with alpha-tubulin at the manchette in developing spermatids. Detected in the flagellum of mature testicular spermatozoa, and in the flagellum and post-acrosomal region of the head of epididymal spermatozoa. Detected in cilia in trachea and oviduct. {ECO:0000250|UniProtKB:Q80W32}.
Q9H0A0	reviewed	NAT10_HUMAN	RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP)	NAT10 ALP KIAA1709	Homo sapiens (Human)	1025	FUNCTION: RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797}.		negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of translation [GO:0045727]; protein acetylation [GO:0006473]; regulation of centrosome duplication [GO:0010824]; ribosomal small subunit biogenesis [GO:0042274]; rRNA acetylation involved in maturation of SSU-rRNA [GO:1904812]; rRNA modification [GO:0000154]; tRNA acetylation [GO:0051391]	chromosome, telomeric region [GO:0000781]; membrane [GO:0016020]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; telomerase holoenzyme complex [GO:0005697]	ATP binding [GO:0005524]; DNA polymerase binding [GO:0070182]; mRNA N-acetyltransferase activity [GO:0106162]; N-acetyltransferase activity [GO:0008080]; RNA binding [GO:0003723]; rRNA cytidine N-acetyltransferase activity [GO:1990883]; tRNA binding [GO:0000049]	chromosome, telomeric region [GO:0000781]; membrane [GO:0016020]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; telomerase holoenzyme complex [GO:0005697]; ATP binding [GO:0005524]; DNA polymerase binding [GO:0070182]; mRNA N-acetyltransferase activity [GO:0106162]; N-acetyltransferase activity [GO:0008080]; RNA binding [GO:0003723]; rRNA cytidine N-acetyltransferase activity [GO:1990883]; tRNA binding [GO:0000049]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of translation [GO:0045727]; protein acetylation [GO:0006473]; regulation of centrosome duplication [GO:0010824]; ribosomal small subunit biogenesis [GO:0042274]; rRNA acetylation involved in maturation of SSU-rRNA [GO:1904812]; rRNA modification [GO:0000154]; tRNA acetylation [GO:0051391]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03211, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:24786082, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:34516797}. Midbody {ECO:0000255|HAMAP-Rule:MF_03211, ECO:0000269|PubMed:19303003}. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase. {ECO:0000269|PubMed:19303003}.
Q9H0A6	reviewed	RNF32_HUMAN	RING finger protein 32	RNF32 FKSG33 HSD15	Homo sapiens (Human)	362	FUNCTION: May play a role in sperm formation. {ECO:0000269|PubMed:11890671}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		aggresome [GO:0016235]; cytosol [GO:0005829]; endosome [GO:0005768]; nuclear body [GO:0016604]	metal ion binding [GO:0046872]	aggresome [GO:0016235]; cytosol [GO:0005829]; endosome [GO:0005768]; nuclear body [GO:0016604]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11890671}.
Q9H0A8	reviewed	COMD4_HUMAN	COMM domain-containing protein 4	COMMD4	Homo sapiens (Human)	199	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. {ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
Q9H0A9	reviewed	SPC1L_HUMAN	Speriolin-like protein (Spermatogenesis and centriole-associated protein 1-like protein)	SPATC1L C21orf56	Homo sapiens (Human)	340		MISCELLANEOUS: Highly variable expression among individuals is associated with differential sensitivity to the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), decreased expression being associated with increased sensitivity.	actin polymerization or depolymerization [GO:0008154]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein phosphorylation [GO:0001934]; spermatogenesis [GO:0007283]	centrosome [GO:0005813]; sperm connecting piece [GO:0097224]	identical protein binding [GO:0042802]; protein kinase A regulatory subunit binding [GO:0034237]	centrosome [GO:0005813]; sperm connecting piece [GO:0097224]; identical protein binding [GO:0042802]; protein kinase A regulatory subunit binding [GO:0034237]; actin polymerization or depolymerization [GO:0008154]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein phosphorylation [GO:0001934]; spermatogenesis [GO:0007283]	
Q9H0B3	reviewed	IQCN_HUMAN	IQ domain-containing protein N	IQCN KIAA1683	Homo sapiens (Human)	1180	FUNCTION: Essential for spermiogenesis and fertilization (PubMed:36321563). May be required for manchette assembly in elongating spermatids (By similarity). {ECO:0000250|UniProtKB:A0A1D5RMD1, ECO:0000269|PubMed:36321563}.		spermatid development [GO:0007286]	mitochondrion [GO:0005739]; nucleus [GO:0005634]		mitochondrion [GO:0005739]; nucleus [GO:0005634]; spermatid development [GO:0007286]	
Q9H0B6	reviewed	KLC2_HUMAN	Kinesin light chain 2 (KLC 2)	KLC2	Homo sapiens (Human)	622	FUNCTION: Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}.		lysosome localization [GO:0032418]; microtubule-based movement [GO:0007018]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinesin I complex [GO:0016938]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	cadherin binding [GO:0045296]; kinesin binding [GO:0019894]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinesin I complex [GO:0016938]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; cadherin binding [GO:0045296]; kinesin binding [GO:0019894]; lysosome localization [GO:0032418]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:22172677}; Peripheral membrane protein {ECO:0000305|PubMed:22172677}; Cytoplasmic side {ECO:0000305|PubMed:22172677}.
Q9H0B8	reviewed	CRLD2_HUMAN	Cysteine-rich secretory protein LCCL domain-containing 2 (Cysteine-rich secretory protein 11) (CRISP-11) (LCCL domain-containing cysteine-rich secretory protein 2)	CRISPLD2 CRISP11 LCRISP2 UNQ2914/PRO1156/PRO9783	Homo sapiens (Human)	497	FUNCTION: Promotes matrix assembly. {ECO:0000250}.		extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; lung development [GO:0030324]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; transport vesicle [GO:0030133]	glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; transport vesicle [GO:0030133]; glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; lung development [GO:0030324]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q9H0C1	reviewed	ZMY12_HUMAN	Zinc finger MYND domain-containing protein 12	ZMYND12	Homo sapiens (Human)	365					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q9H0C2	reviewed	ADT4_HUMAN	ADP/ATP translocase 4 (ADP,ATP carrier protein 4) (Adenine nucleotide translocator 4) (ANT 4) (Solute carrier family 25 member 31) (Sperm flagellar energy carrier protein)	SLC25A31 AAC4 ANT4 SFEC	Homo sapiens (Human)	315	FUNCTION: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:15670820) (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes (PubMed:17137571). Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Among nucleotides, may also exchange ADP for dATP and dADP (PubMed:15670820). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (By similarity). It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000250|UniProtKB:Q3V132, ECO:0000269|PubMed:15670820, ECO:0000269|PubMed:17137571}.		cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; regulation of mitochondrial membrane permeability [GO:0046902]; spermatogenesis [GO:0007283]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP:ADP antiporter activity [GO:0005471]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP:ADP antiporter activity [GO:0005471]; cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; regulation of mitochondrial membrane permeability [GO:0046902]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:15670820}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:27641616}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:17137571}; Multi-pass membrane protein {ECO:0000255}. Note=In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region (PubMed:17137571). May localize to non-mitochondrial membranes (PubMed:27641616). {ECO:0000269|PubMed:17137571, ECO:0000269|PubMed:27641616}.
Q9H0C5	reviewed	BTBD1_HUMAN	BTB/POZ domain-containing protein 1 (Hepatitis C virus NS5A-transactivated protein 8) (HCV NS5A-transactivated protein 8)	BTBD1 C15orf1 NS5ATP8	Homo sapiens (Human)	482	FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). {ECO:0000250|UniProtKB:P58544, ECO:0000269|PubMed:14528312}.		muscle organ development [GO:0007517]; neurogenesis [GO:0022008]; protein ubiquitination [GO:0016567]; regulation of protein binding [GO:0043393]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; protein-containing complex [GO:0032991]	cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]; muscle organ development [GO:0007517]; neurogenesis [GO:0022008]; protein ubiquitination [GO:0016567]; regulation of protein binding [GO:0043393]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11818025, ECO:0000269|PubMed:12878161}. Note=Localizes to punctate or elongated cytoplasmic bodies. {ECO:0000269|PubMed:11818025, ECO:0000269|PubMed:12878161}.
Q9H0C8	reviewed	ILKAP_HUMAN	Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16)	ILKAP	Homo sapiens (Human)	392	FUNCTION: Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. {ECO:0000269|PubMed:14990992}.			cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11331582}.
Q9H0D2	reviewed	ZN541_HUMAN	Zinc finger protein 541	ZNF541	Homo sapiens (Human)	1346	FUNCTION: Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes. Regulates progression of the pachytene stage of meiotic prophase by activating the expression of genes involved in meiosis during spermatogenesis. Maintains the repression of pre-pachytene transcriptional programs, including meiotic double-strand breaks (DSB) formation genes in pachytene spermatocytes and suppresses aberrant DSB formation after mid-pachytene, thus ensuring meiosis progression. {ECO:0000250|UniProtKB:Q0GGX2}.		cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q0GGX2, ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.
Q9H0D6	reviewed	XRN2_HUMAN	5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein)	XRN2	Homo sapiens (Human)	950	FUNCTION: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158, ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}.		hippocampus development [GO:0021766]; mRNA processing [GO:0006397]; neuron differentiation [GO:0030182]; nuclear-transcribed mRNA catabolic process [GO:0000956]; retina development in camera-type eye [GO:0060041]; RNA catabolic process [GO:0006401]; RNA metabolic process [GO:0016070]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; spermatogenesis [GO:0007283]; termination of RNA polymerase II transcription [GO:0006369]	aggresome [GO:0016235]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5'-RNA exonuclease activity [GO:0000175]; 5'-3' exonuclease activity [GO:0008409]; 5'-3' RNA exonuclease activity [GO:0004534]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; RNA binding [GO:0003723]; transcription termination site sequence-specific DNA binding [GO:0001147]	aggresome [GO:0016235]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5'-RNA exonuclease activity [GO:0000175]; 5'-3' exonuclease activity [GO:0008409]; 5'-3' RNA exonuclease activity [GO:0004534]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; RNA binding [GO:0003723]; transcription termination site sequence-specific DNA binding [GO:0001147]; hippocampus development [GO:0021766]; mRNA processing [GO:0006397]; neuron differentiation [GO:0030182]; nuclear-transcribed mRNA catabolic process [GO:0000956]; retina development in camera-type eye [GO:0060041]; RNA catabolic process [GO:0006401]; RNA metabolic process [GO:0016070]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; spermatogenesis [GO:0007283]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Q9H0E2	reviewed	TOLIP_HUMAN	Toll-interacting protein	TOLLIP	Homo sapiens (Human)	274	FUNCTION: Component of the signaling pathway of IL-1 and Toll-like receptors (PubMed:10854325, PubMed:11751856). Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex (PubMed:10854325). Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (PubMed:25042851). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:26320582). {ECO:0000269|PubMed:10854325, ECO:0000269|PubMed:11751856, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:25042851, ECO:0000269|PubMed:26320582}.		autophagy [GO:0006914]; epithelial cell differentiation [GO:0030855]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; leukocyte activation [GO:0045321]; phosphorylation [GO:0016310]; positive regulation of protein sumoylation [GO:0033235]; protein localization to endosome [GO:0036010]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extrinsic component of plasma membrane [GO:0019897]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580]	interleukin-1, type I receptor binding [GO:0005150]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; SUMO binding [GO:0032183]; Toll-like receptor binding [GO:0035325]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extrinsic component of plasma membrane [GO:0019897]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580]; interleukin-1, type I receptor binding [GO:0005150]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; SUMO binding [GO:0032183]; Toll-like receptor binding [GO:0035325]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625]; autophagy [GO:0006914]; epithelial cell differentiation [GO:0030855]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; leukocyte activation [GO:0045321]; phosphorylation [GO:0016310]; positive regulation of protein sumoylation [GO:0033235]; protein localization to endosome [GO:0036010]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31263572}. Endosome {ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:31263572}. Early endosome {ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:26320582}. Note=Localized to endo/exosomal vesicles. {ECO:0000269|PubMed:31263572}.
Q9H0E3	reviewed	SP130_HUMAN	Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130)	SAP130	Homo sapiens (Human)	1048	FUNCTION: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}.		negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; Sin3-type complex [GO:0070822]		nuclear speck [GO:0016607]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; Sin3-type complex [GO:0070822]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15561718}.
Q9H0E7	reviewed	UBP44_HUMAN	Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.4.19.12) (Deubiquitinating enzyme 44) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44)	USP44	Homo sapiens (Human)	712	FUNCTION: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (PubMed:17443180). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C (PubMed:17443180). Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint (PubMed:17443180). Promotes also the deubiquitination of histone H2A and H2B (PubMed:23615962, PubMed:27880911). Recruited to RNF8/RNF168-ubiquitinated chromatin surrounding double stranded breaks (DSBs), promotes hydrolysis of such ubiquitin conjugates, thus negatively regulating protein recruitment to damaged chromatin (PubMed:23615962). Participates in nucleotide excision repair (NER) pathway by deubiquitinating DDB2 to prevent its premature degradation so it can remain on damaged chromatin (By similarity). Promotes FOXP3 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability and increased regulatory T-cell lineage stability (PubMed:32644293). Plays also a positive role in innate immune response to DNA viruses by deubiquitinating STING1, selectively removing its 'Lys-48'-linked polyubiquitin chains and stabilizing it (PubMed:31968013). {ECO:0000250|UniProtKB:Q8C2S0, ECO:0000269|PubMed:17443180, ECO:0000269|PubMed:22681888, ECO:0000269|PubMed:23615962, ECO:0000269|PubMed:27880911, ECO:0000269|PubMed:31968013, ECO:0000269|PubMed:32644293}.		antiviral innate immune response [GO:0140374]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; nucleotide-excision repair [GO:0006289]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; regulatory T cell differentiation [GO:0045066]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; zinc ion binding [GO:0008270]; antiviral innate immune response [GO:0140374]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; nucleotide-excision repair [GO:0006289]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; regulatory T cell differentiation [GO:0045066]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20402667, ECO:0000269|PubMed:23615962, ECO:0000269|PubMed:31968013, ECO:0000269|PubMed:32644293}. Cytoplasm {ECO:0000269|PubMed:31968013}. Note=Peaks in interphase, with relatively low levels maintained throughout mitosis. {ECO:0000250}.
Q9H0E9	reviewed	BRD8_HUMAN	Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120)	BRD8 SMAP SMAP2	Homo sapiens (Human)	1235	FUNCTION: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.		cell surface receptor signaling pathway [GO:0007166]; cellular response to thyroid hormone stimulus [GO:0097067]; chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]	mitochondrion [GO:0005739]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]	nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]	mitochondrion [GO:0005739]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; cell surface receptor signaling pathway [GO:0007166]; cellular response to thyroid hormone stimulus [GO:0097067]; chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309}.
Q9H0F5	reviewed	RNF38_HUMAN	E3 ubiquitin-protein ligase RNF38 (EC 2.3.2.27) (RING finger protein 38) (RING-type E3 ubiquitin transferase RNF38)	RNF38	Homo sapiens (Human)	515	FUNCTION: Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme. {ECO:0000269|PubMed:23973461}.		male gonad development [GO:0008584]; protein ubiquitination [GO:0016567]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; male gonad development [GO:0008584]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23973461}.
Q9H0F6	reviewed	SHRPN_HUMAN	Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1)	SHARPIN SIPL1 PSEC0216	Homo sapiens (Human)	387	FUNCTION: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}.		apoptotic nuclear changes [GO:0030262]; defense response to bacterium [GO:0042742]; keratinization [GO:0031424]; mitochondrion organization [GO:0007005]; negative regulation of inflammatory response [GO:0050728]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein linear polyubiquitination [GO:0097039]; regulation of CD40 signaling pathway [GO:2000348]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]	cytosol [GO:0005829]; dendrite [GO:0030425]; LUBAC complex [GO:0071797]; synapse [GO:0045202]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; dendrite [GO:0030425]; LUBAC complex [GO:0071797]; synapse [GO:0045202]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic nuclear changes [GO:0030262]; defense response to bacterium [GO:0042742]; keratinization [GO:0031424]; mitochondrion organization [GO:0007005]; negative regulation of inflammatory response [GO:0050728]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein linear polyubiquitination [GO:0097039]; regulation of CD40 signaling pathway [GO:2000348]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20179993}. Synapse {ECO:0000250|UniProtKB:Q9EQL9}. Note=Enriched at synaptic sites in mature neurons where it colocalizes with SHANK1. {ECO:0000250|UniProtKB:Q9EQL9}.
Q9H0F7	reviewed	ARL6_HUMAN	ADP-ribosylation factor-like protein 6 (Bardet-Biedl syndrome 3 protein)	ARL6 BBS3	Homo sapiens (Human)	186	FUNCTION: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729). Isoform 2 may be required for proper retinal function and organization (By similarity). {ECO:0000250|UniProtKB:O88848, ECO:0000269|PubMed:20207729, ECO:0000269|PubMed:20603001, ECO:0000269|PubMed:22072986}.		cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; protein localization to cilium [GO:0061512]; protein polymerization [GO:0051258]; protein targeting to membrane [GO:0006612]; vesicle-mediated transport [GO:0016192]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]	axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane coat [GO:0030117]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]	axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane coat [GO:0030117]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; protein localization to cilium [GO:0061512]; protein polymerization [GO:0051258]; protein targeting to membrane [GO:0006612]; vesicle-mediated transport [GO:0016192]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Note=Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane.
Q9H0G5	reviewed	NSRP1_HUMAN	Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70)	NSRP1 CCDC55 NSRP70	Homo sapiens (Human)	558	FUNCTION: RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}.		developmental process [GO:0032502]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; developmental process [GO:0032502]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21296756}. Nucleus speckle {ECO:0000269|PubMed:21296756}. Note=Colocalizes with splicing factors SRSF1 and SRSF2 in speckles.
Q9H0H0	reviewed	INT2_HUMAN	Integrator complex subunit 2 (Int2)	INTS2 KIAA1287	Homo sapiens (Human)	1204	FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.		regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	cytoplasm [GO:0005737]; integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:16239144}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:23904267}.
Q9H0H3	reviewed	KLH25_HUMAN	Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2)	KLHL25 ENC2	Homo sapiens (Human)	589	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:27664236, PubMed:34491895). The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813). The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813). The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:27664236, PubMed:34491895). BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895). {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:27664236, ECO:0000269|PubMed:34491895}.		negative regulation of fatty acid biosynthetic process [GO:0045717]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of fatty acid oxidation [GO:0046321]; protein ubiquitination [GO:0016567]; regulation of translational initiation [GO:0006446]; ubiquitin-dependent protein catabolic process [GO:0006511]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; negative regulation of fatty acid biosynthetic process [GO:0045717]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of fatty acid oxidation [GO:0046321]; protein ubiquitination [GO:0016567]; regulation of translational initiation [GO:0006446]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q9H0H5	reviewed	RGAP1_HUMAN	Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)	RACGAP1 KIAA1478 MGCRACGAP	Homo sapiens (Human)	632	FUNCTION: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}.		actomyosin contractile ring assembly [GO:0000915]; erythrocyte differentiation [GO:0030218]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; monoatomic ion transport [GO:0006811]; neuroblast proliferation [GO:0007405]; positive regulation of cytokinesis [GO:0032467]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of embryonic development [GO:0045995]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; sulfate transport [GO:0008272]	acrosomal vesicle [GO:0001669]; centralspindlin complex [GO:0097149]; cleavage furrow [GO:0032154]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle midzone [GO:0051233]	alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; gamma-tubulin binding [GO:0043015]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]	acrosomal vesicle [GO:0001669]; centralspindlin complex [GO:0097149]; cleavage furrow [GO:0032154]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle midzone [GO:0051233]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; gamma-tubulin binding [GO:0043015]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; actomyosin contractile ring assembly [GO:0000915]; erythrocyte differentiation [GO:0030218]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; monoatomic ion transport [GO:0006811]; neuroblast proliferation [GO:0007405]; positive regulation of cytokinesis [GO:0032467]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of embryonic development [GO:0045995]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; sulfate transport [GO:0008272]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18445686}. Cytoplasm. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Cytoplasmic vesicle, secretory vesicle, acrosome. Cleavage furrow. Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome (By similarity). During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody ring, also called Flemming body. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase. {ECO:0000250}.
Q9H0I2	reviewed	ENKD1_HUMAN	Enkurin domain-containing protein 1	ENKD1 C16orf48 UNQ6410/PRO21183	Homo sapiens (Human)	346	FUNCTION: Microtubule-binding protein which regulates microtubule organization and stability (PubMed:35197565, PubMed:35072334). Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle (PubMed:35197565). This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (By similarity). Required for the assembly of both primary and motile cilia (PubMed:35301795). Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed:35301795). {ECO:0000250|UniProtKB:Q7TSV9, ECO:0000269|PubMed:35072334, ECO:0000269|PubMed:35197565, ECO:0000269|PubMed:35301795}.		establishment of mitotic spindle orientation [GO:0000132]; motile cilium assembly [GO:0044458]; non-motile cilium assembly [GO:1905515]	9+0 non-motile cilium [GO:0097731]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasmic microtubule [GO:0005881]; microtubule cytoskeleton [GO:0015630]; spindle pole [GO:0000922]	alpha-tubulin binding [GO:0043014]; microtubule binding [GO:0008017]	9+0 non-motile cilium [GO:0097731]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasmic microtubule [GO:0005881]; microtubule cytoskeleton [GO:0015630]; spindle pole [GO:0000922]; alpha-tubulin binding [GO:0043014]; microtubule binding [GO:0008017]; establishment of mitotic spindle orientation [GO:0000132]; motile cilium assembly [GO:0044458]; non-motile cilium assembly [GO:1905515]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:35072334, ECO:0000269|PubMed:35301795}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:35301795}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:35301795}. Cell projection, cilium {ECO:0000269|PubMed:35072334}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:35072334}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:35072334}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:35072334}. Note=Localized at the centrosome and accumulates at the parental centrioles during centriole duplication in cycling cells (PubMed:35301795). In ciliated cells, detected at the basal body of the cilium (PubMed:35301795). Localizes to the centrosome during interphase, to the primary cilium at G0, to the spindle poles during mitosis and to the centrosomes and central spindle during telophase and cytokinesis (PubMed:35072334). {ECO:0000269|PubMed:35072334, ECO:0000269|PubMed:35301795}.
Q9H0J4	reviewed	QRIC2_HUMAN	Glutamine-rich protein 2	QRICH2	Homo sapiens (Human)	1663	FUNCTION: Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility. {ECO:0000269|PubMed:30683861}.		cell projection assembly [GO:0030031]; flagellated sperm motility [GO:0030317]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; sperm flagellum [GO:0036126]		cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; sperm flagellum [GO:0036126]; cell projection assembly [GO:0030031]; flagellated sperm motility [GO:0030317]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q3V2A7}. Nucleus {ECO:0000250|UniProtKB:Q3V2A7}. Cytoplasm {ECO:0000250|UniProtKB:Q3V2A7}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:30683861}. Note=Localization varies during spermatozoa development. The protein is distributed in the nuclear membrane of the spermatogonia, in the nucleus of round spermatids, in the nucleus and cytoplasm of early elongating spermatids, in the cytoplasm of late elongating spermatids, and in the flagella of epididymal spermatozoa. {ECO:0000250|UniProtKB:Q3V2A7}.
Q9H0J9	reviewed	PAR12_HUMAN	Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1)	PARP12 ZC3HDC1	Homo sapiens (Human)	701	FUNCTION: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}.		protein auto-ADP-ribosylation [GO:0070213]	nucleus [GO:0005634]	metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; RNA binding [GO:0003723]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; RNA binding [GO:0003723]; protein auto-ADP-ribosylation [GO:0070213]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H0K1	reviewed	SIK2_HUMAN	Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)	SIK2 KIAA0781 QIK SNF1LK2	Homo sapiens (Human)	926	FUNCTION: Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}.		intracellular signal transduction [GO:0035556]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of insulin receptor signaling pathway [GO:0046626]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of insulin receptor signaling pathway [GO:0046626]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24129571}.
Q9H0K6	reviewed	PUS7L_HUMAN	Pseudouridylate synthase PUS7L (EC 5.4.99.-) (Pseudouridylate synthase 7 homolog-like protein)	PUS7L	Homo sapiens (Human)	701	FUNCTION: Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. {ECO:0000269|PubMed:35051350}.		mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; pseudouridine synthesis [GO:0001522]	nucleus [GO:0005634]	pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]	nucleus [GO:0005634]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; pseudouridine synthesis [GO:0001522]	
Q9H0L4	reviewed	CSTFT_HUMAN	Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64)	CSTF2T KIAA0689	Homo sapiens (Human)	616	FUNCTION: May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}.		mRNA 3'-end processing [GO:0031124]	intracellular membrane-bounded organelle [GO:0043231]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	intracellular membrane-bounded organelle [GO:0043231]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA 3'-end processing [GO:0031124]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9H0M0	reviewed	WWP1_HUMAN	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)	WWP1	Homo sapiens (Human)	922	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. {ECO:0000269|PubMed:12535537, ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:15359284}.		central nervous system development [GO:0007417]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of DNA-templated transcription [GO:0045892]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]; viral entry into host cell [GO:0046718]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; central nervous system development [GO:0007417]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of DNA-templated transcription [GO:0045892]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}.
Q9H0M4	reviewed	ZCPW1_HUMAN	Zinc finger CW-type PWWP domain protein 1	ZCWPW1	Homo sapiens (Human)	648	FUNCTION: Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3) (PubMed:32744506, PubMed:20826339). Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (By similarity). Essential for male fertility and spermatogenesis (By similarity). Required for meiosis prophase I progression in male but not in female germ cells (By similarity). {ECO:0000250|UniProtKB:Q6IR42, ECO:0000269|PubMed:20826339, ECO:0000269|PubMed:32744506}.		cell differentiation [GO:0030154]; homologous chromosome pairing at meiosis [GO:0007129]; meiosis I [GO:0007127]; positive regulation of DNA recombination [GO:0045911]; positive regulation of double-strand break repair [GO:2000781]; spermatogenesis [GO:0007283]	chromosome [GO:0005694]; nucleus [GO:0005634]	methyl-CpG binding [GO:0008327]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; nucleus [GO:0005634]; methyl-CpG binding [GO:0008327]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; homologous chromosome pairing at meiosis [GO:0007129]; meiosis I [GO:0007127]; positive regulation of DNA recombination [GO:0045911]; positive regulation of double-strand break repair [GO:2000781]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6IR42}. Chromosome {ECO:0000250|UniProtKB:Q6IR42}.
Q9H0N0	reviewed	RAB6C_HUMAN	Ras-related protein Rab-6C (Rab6-like protein WTH3)	RAB6C WTH3	Homo sapiens (Human)	254	FUNCTION: May be involved in the regulation of centrosome duplication and cell cycle progression. {ECO:0000269|PubMed:17426708, ECO:0000269|PubMed:18992151, ECO:0000269|PubMed:20064528}.	MISCELLANEOUS: Primate-specific retrogene derived from isoform 2 of RAB6A transcript.; MISCELLANEOUS: Previously reported to exhibit GTP-binding affinity comparable to that of RAB6A (PubMed:16103095). In contrast (PubMed:20064528) concludes that RAB6C is an inefficient GTP-binding. {ECO:0000305|PubMed:16103095, ECO:0000305|PubMed:20064528}.	intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; regulation of centrosome duplication [GO:0010824]; response to xenobiotic stimulus [GO:0009410]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; small GTPase mediated signal transduction [GO:0007264]	centrosome [GO:0005813]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	centrosome [GO:0005813]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; regulation of centrosome duplication [GO:0010824]; response to xenobiotic stimulus [GO:0009410]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16103095}. Cytoplasm {ECO:0000269|PubMed:16103095}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20064528}.
Q9H0N5	reviewed	PHS2_HUMAN	Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor)	PCBD2 DCOH2 DCOHM	Homo sapiens (Human)	130	FUNCTION: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). {ECO:0000250}.; FUNCTION: Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity. {ECO:0000269|PubMed:11980910}.		positive regulation of DNA-templated transcription [GO:0045893]; tetrahydrobiopterin biosynthetic process [GO:0006729]	nucleus [GO:0005634]	4-alpha-hydroxytetrahydrobiopterin dehydratase activity [GO:0008124]; identical protein binding [GO:0042802]; phenylalanine 4-monooxygenase activity [GO:0004505]	nucleus [GO:0005634]; 4-alpha-hydroxytetrahydrobiopterin dehydratase activity [GO:0008124]; identical protein binding [GO:0042802]; phenylalanine 4-monooxygenase activity [GO:0004505]; positive regulation of DNA-templated transcription [GO:0045893]; tetrahydrobiopterin biosynthetic process [GO:0006729]	
Q9H0P0	reviewed	5NT3A_HUMAN	Cytosolic 5'-nucleotidase 3A (EC 3.1.3.5) (7-methylguanosine phosphate-specific 5'-nucleotidase) (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3) (Cytosolic 5'-nucleotidase III) (cN-III) (Pyrimidine 5'-nucleotidase 1) (P5'N-1) (P5N-1) (PN-I) (Uridine 5'-monophosphate hydrolase 1) (p36)	NT5C3A NT5C3 P5N1 UMPH1 HSPC233	Homo sapiens (Human)	336	FUNCTION: Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458). {ECO:0000269|PubMed:15968458, ECO:0000269|PubMed:24603684}.		defense response to virus [GO:0051607]; nucleotide metabolic process [GO:0009117]; pyrimidine nucleoside metabolic process [GO:0006213]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; tRNA 2'-phosphotransferase activity [GO:0000215]; XMP 5'-nucleosidase activity [GO:0106411]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; tRNA 2'-phosphotransferase activity [GO:0000215]; XMP 5'-nucleosidase activity [GO:0106411]; defense response to virus [GO:0051607]; nucleotide metabolic process [GO:0009117]; pyrimidine nucleoside metabolic process [GO:0006213]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum.
Q9H0Q3	reviewed	FXYD6_HUMAN	FXYD domain-containing ion transport regulator 6 (Phosphohippolin)	FXYD6 UNQ521/PRO1056	Homo sapiens (Human)	95			monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	sodium channel regulator activity [GO:0017080]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; sodium channel regulator activity [GO:0017080]; monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9H0R1	reviewed	AP5M1_HUMAN	AP-5 complex subunit mu-1 (Adaptor-related protein complex 5 subunit mu-1) (Mu5) (Mu-2-related death-inducing protein) (MuD) (Putative HIV-1 infection-related protein)	AP5M1 C14orf108 MUDENG	Homo sapiens (Human)	490	FUNCTION: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death. {ECO:0000269|PubMed:18395520, ECO:0000269|PubMed:22022230}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	endosomal transport [GO:0016197]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; cytosol [GO:0005829]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]		AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; cytosol [GO:0005829]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22022230}. Late endosome membrane {ECO:0000305|PubMed:22022230}; Peripheral membrane protein {ECO:0000305|PubMed:22022230}; Cytoplasmic side {ECO:0000305|PubMed:22022230}. Lysosome membrane {ECO:0000305|PubMed:22022230}; Peripheral membrane protein {ECO:0000305|PubMed:22022230}; Cytoplasmic side {ECO:0000305|PubMed:22022230}. Note=May cycle on and off membranes.
Q9H0R3	reviewed	TM222_HUMAN	Transmembrane protein 222	TMEM222 C1orf160	Homo sapiens (Human)	208				dendrite [GO:0030425]; membrane [GO:0016020]		dendrite [GO:0030425]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:33824500}.
Q9H0R5	reviewed	GBP3_HUMAN	Guanylate-binding protein 3 (EC 3.6.5.-) (GTP-binding protein 3) (GBP-3) (Guanine nucleotide-binding protein 3)	GBP3	Homo sapiens (Human)	595	FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:22106366). Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Exhibits antiviral activity against influenza virus (PubMed:22106366). {ECO:0000250|UniProtKB:Q61107, ECO:0000269|PubMed:22106366}.; FUNCTION: [Isoform 2]: Shows the most prominent antiviral activity in epithelial cells. {ECO:0000269|PubMed:22106366}.		cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; positive regulation of pyroptosis [GO:0140639]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; positive regulation of pyroptosis [GO:0140639]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17266443}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21151871}. Golgi apparatus membrane {ECO:0000269|PubMed:21151871}. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. {ECO:0000269|PubMed:21151871}.
Q9H0R6	reviewed	GATA_HUMAN	Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1)	QRSL1	Homo sapiens (Human)	528	FUNCTION: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03150, ECO:0000269|PubMed:19805282}.		glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543]; regulation of protein stability [GO:0031647]	glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567]	glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567]; glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03150, ECO:0000269|PubMed:19805282}.
Q9H0R8	reviewed	GBRL1_HUMAN	Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)	GABARAPL1 GEC1	Homo sapiens (Human)	117	FUNCTION: Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). {ECO:0000269|PubMed:16431922, ECO:0000269|PubMed:20404487, ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}.		autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; glycophagy [GO:0061723]; macroautophagy [GO:0016236]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]	beta-tubulin binding [GO:0048487]; GABA receptor binding [GO:0050811]; phospholipid binding [GO:0005543]; Tat protein binding [GO:0030957]; ubiquitin protein ligase binding [GO:0031625]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; beta-tubulin binding [GO:0048487]; GABA receptor binding [GO:0050811]; phospholipid binding [GO:0005543]; Tat protein binding [GO:0030957]; ubiquitin protein ligase binding [GO:0031625]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; glycophagy [GO:0061723]; macroautophagy [GO:0016236]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:20404487, ECO:0000269|PubMed:30661429, ECO:0000305|PubMed:23690988}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:20404487}; Lipid-anchor {ECO:0000269|PubMed:20404487}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q0VGK0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q0VGK0}. Golgi apparatus {ECO:0000250|UniProtKB:Q0VGK0}.
Q9H0S4	reviewed	DDX47_HUMAN	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47)	DDX47	Homo sapiens (Human)	455	FUNCTION: Required for efficient ribosome biogenesis (By similarity). May have a role in mRNA splicing (PubMed:16963496). Involved in apoptosis (PubMed:15977068). {ECO:0000250|UniProtKB:Q9VIF6, ECO:0000269|PubMed:15977068, ECO:0000269|PubMed:16963496}.		extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16963496}. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis.
Q9H0T7	reviewed	RAB17_HUMAN	Ras-related protein Rab-17	RAB17	Homo sapiens (Human)	212	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration. {ECO:0000250, ECO:0000269|PubMed:22328529}.		cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; establishment of melanosome localization [GO:0032401]; filopodium assembly [GO:0046847]; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor [GO:0002415]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; regulation of dendrite development [GO:0050773]; regulation of endocytosis [GO:0030100]; regulation of filopodium assembly [GO:0051489]; regulation of synapse assembly [GO:0051963]; transcytosis [GO:0045056]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; melanosome [GO:0042470]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; melanosome [GO:0042470]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; establishment of melanosome localization [GO:0032401]; filopodium assembly [GO:0046847]; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor [GO:0002415]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; regulation of dendrite development [GO:0050773]; regulation of endocytosis [GO:0030100]; regulation of filopodium assembly [GO:0051489]; regulation of synapse assembly [GO:0051963]; transcytosis [GO:0045056]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:P35292}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome {ECO:0000250|UniProtKB:P35292}. Cell projection, dendrite {ECO:0000250|UniProtKB:P35292}. Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine. {ECO:0000250|UniProtKB:P35292}.
Q9H0U3	reviewed	MAGT1_HUMAN	Magnesium transporter protein 1 (MagT1) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1) (Oligosaccharyl transferase subunit MAGT1) (Implantation-associated protein) (IAP)	MAGT1 IAG2 PSEC0084 UNQ628/PRO1244	Homo sapiens (Human)	335	FUNCTION: Accessory component of the STT3B-containing form of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (PubMed:31831667). Involved in N-glycosylation of STT3B-dependent substrates (PubMed:31831667). Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. {ECO:0000269|PubMed:25135935, ECO:0000269|PubMed:26864433, ECO:0000269|PubMed:31036665, ECO:0000269|PubMed:31831667, ECO:0000305}.; FUNCTION: May be involved in Mg(2+) transport in epithelial cells. {ECO:0000305|PubMed:15804357, ECO:0000305|PubMed:19717468}.		cognition [GO:0050890]; magnesium ion transport [GO:0015693]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; transmembrane transport [GO:0055085]	azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]	magnesium ion transmembrane transporter activity [GO:0015095]	azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]; magnesium ion transmembrane transporter activity [GO:0015095]; cognition [GO:0050890]; magnesium ion transport [GO:0015693]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19717468}; Multi-pass membrane protein {ECO:0000269|PubMed:19717468}. Endoplasmic reticulum {ECO:0000269|PubMed:25135935}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9H0U4	reviewed	RAB1B_HUMAN	Ras-related protein Rab-1B (EC 3.6.5.2)	RAB1B	Homo sapiens (Human)	201	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:9437002}.	MISCELLANEOUS: Rab-1B binds GTP and GDP and possesses low intrinsic GTPase activity.	autophagosome assembly [GO:0000045]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of glycoprotein metabolic process [GO:1903020]; regulation of autophagosome assembly [GO:2000785]; virion assembly [GO:0019068]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site membrane [GO:0034045]; transport vesicle [GO:0030133]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site membrane [GO:0034045]; transport vesicle [GO:0030133]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagosome assembly [GO:0000045]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of glycoprotein metabolic process [GO:1903020]; regulation of autophagosome assembly [GO:2000785]; virion assembly [GO:0019068]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11389151}. Membrane {ECO:0000269|PubMed:11389151}; Lipid-anchor {ECO:0000269|PubMed:11389151}; Cytoplasmic side {ECO:0000269|PubMed:11389151}. Preautophagosomal structure membrane {ECO:0000269|PubMed:20545908}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P10536}. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments (PubMed:11389151). In the GDP-form, colocalizes with GDI in the cytoplasm (PubMed:11389151). Co-localizes with MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment and to the peri-Golgi region (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:11389151}.
Q9H0U6	reviewed	RM18_HUMAN	Large ribosomal subunit protein uL18m (39S ribosomal protein L18, mitochondrial) (L18mt) (MRP-L18)	MRPL18 HSPC071	Homo sapiens (Human)	180	FUNCTION: Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA. {ECO:0000269|PubMed:21685364}.		mitochondrial translation [GO:0032543]; rRNA import into mitochondrion [GO:0035928]; translation [GO:0006412]	extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	5S rRNA binding [GO:0008097]; structural constituent of ribosome [GO:0003735]	extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; 5S rRNA binding [GO:0008097]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; rRNA import into mitochondrion [GO:0035928]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:28892042}.
Q9H0V9	reviewed	LMA2L_HUMAN	VIP36-like protein (Lectin mannose-binding 2-like) (LMAN2-like protein)	LMAN2L VIPL PSEC0028 UNQ368/PRO704	Homo sapiens (Human)	348	FUNCTION: May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53. {ECO:0000269|PubMed:12878160}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein folding [GO:0006457]; protein transport [GO:0015031]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	mannose binding [GO:0005537]; metal ion binding [GO:0046872]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein folding [GO:0006457]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.
Q9H0W5	reviewed	CCDC8_HUMAN	Coiled-coil domain-containing protein 8	CCDC8	Homo sapiens (Human)	538	FUNCTION: Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). {ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}.		microtubule cytoskeleton organization [GO:0000226]; regulation of mitotic nuclear division [GO:0007088]	3M complex [GO:1990393]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		3M complex [GO:1990393]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; microtubule cytoskeleton organization [GO:0000226]; regulation of mitotic nuclear division [GO:0007088]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24793695}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24793695}.
Q9H0W8	reviewed	SMG9_HUMAN	Nonsense-mediated mRNA decay factor SMG9	SMG9 C19orf61	Homo sapiens (Human)	520	FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}.		brain development [GO:0007420]; eye development [GO:0001654]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]	cytosol [GO:0005829]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; identical protein binding [GO:0042802]; brain development [GO:0007420]; eye development [GO:0001654]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]	
Q9H0W9	reviewed	CK054_HUMAN	Ester hydrolase C11orf54 (EC 3.1.-.-)	C11orf54 LP4947 PTD012	Homo sapiens (Human)	315	FUNCTION: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate. {ECO:0000269|PubMed:16522806}.	MISCELLANEOUS: [Isoform 3]: Probably non-functional. {ECO:0000305}.		extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	hydrolase activity, acting on ester bonds [GO:0016788]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; hydrolase activity, acting on ester bonds [GO:0016788]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16522806}.
Q9H0X6	reviewed	RN208_HUMAN	RING finger protein 208	RNF208	Homo sapiens (Human)	261			protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	
Q9H0X9	reviewed	OSBL5_HUMAN	Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1)	OSBPL5 KIAA1534 OBPH1 ORP5	Homo sapiens (Human)	879	FUNCTION: Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}.	MISCELLANEOUS: According to a report, the gene is imprinted in placenta, where it is predominantly expressed from the maternal allele only. Not imprinted in other tissues (PubMed:12504849). According to another report, it is not imprinted in trophoblast stem cells (PubMed:20644730). {ECO:0000269|PubMed:12504849, ECO:0000269|PubMed:20644730}.	cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; Golgi to plasma membrane transport [GO:0006893]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid transport [GO:0015914]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	cholesterol binding [GO:0015485]; oxysterol binding [GO:0008142]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; phosphatidylserine transfer activity [GO:0140343]; phospholipid transporter activity [GO:0005548]; sterol binding [GO:0032934]; sterol transporter activity [GO:0015248]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; cholesterol binding [GO:0015485]; oxysterol binding [GO:0008142]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; phosphatidylserine transfer activity [GO:0140343]; phospholipid transporter activity [GO:0005548]; sterol binding [GO:0032934]; sterol transporter activity [GO:0015248]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; Golgi to plasma membrane transport [GO:0006893]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid transport [GO:0015914]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:26206935}; Single-pass membrane protein {ECO:0000269|PubMed:21220512}. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Localizes to the cortical endoplasmic reticulum at the EPCS. {ECO:0000269|PubMed:26206935, ECO:0000269|PubMed:30220461}.
Q9H0Y0	reviewed	ATG10_HUMAN	Ubiquitin-like-conjugating enzyme ATG10 (EC 2.3.2.-) (Autophagy-related protein 10) (APG10-like)	ATG10 APG10L PP12616	Homo sapiens (Human)	220	FUNCTION: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. {ECO:0000250, ECO:0000269|PubMed:21367888}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; ER overload response [GO:0006983]; macroautophagy [GO:0016236]; positive regulation of protein modification process [GO:0031401]; protein lipidation [GO:0006497]; protein modification by small protein conjugation [GO:0032446]; protein transport [GO:0015031]	cytosol [GO:0005829]	Atg12 conjugating enzyme activity [GO:0061651]; Atg12 transferase activity [GO:0019777]	cytosol [GO:0005829]; Atg12 conjugating enzyme activity [GO:0061651]; Atg12 transferase activity [GO:0019777]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; ER overload response [GO:0006983]; macroautophagy [GO:0016236]; positive regulation of protein modification process [GO:0031401]; protein lipidation [GO:0006497]; protein modification by small protein conjugation [GO:0032446]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q9H0Z9	reviewed	RBM38_HUMAN	RNA-binding protein 38 (CLL-associated antigen KW-5) (HSRNASEB) (RNA-binding motif protein 38) (RNA-binding region-containing protein 1) (ssDNA-binding protein SEB4)	RBM38 RNPC1 SEB4	Homo sapiens (Human)	239	FUNCTION: RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. {ECO:0000269|PubMed:17050675, ECO:0000269|PubMed:19285943}.; FUNCTION: (Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication. {ECO:0000269|PubMed:29437973}.		3'-UTR-mediated mRNA stabilization [GO:0070935]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; mRNA processing [GO:0006397]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell cycle [GO:0051726]; regulation of myotube differentiation [GO:0010830]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	cytosol [GO:0005829]; nucleus [GO:0005634]	mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleus [GO:0005634]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; mRNA processing [GO:0006397]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell cycle [GO:0051726]; regulation of myotube differentiation [GO:0010830]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17050675}. Nucleus {ECO:0000269|PubMed:17050675}.
Q9H112	reviewed	CST11_HUMAN	Cystatin-11	CST11 CST8L	Homo sapiens (Human)	138	FUNCTION: Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. {ECO:0000269|PubMed:12072414}.		androgen receptor signaling pathway [GO:0030521]; defense response to Gram-negative bacterium [GO:0050829]; killing of cells of another organism [GO:0031640]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]	cysteine-type endopeptidase inhibitor activity [GO:0004869]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; androgen receptor signaling pathway [GO:0030521]; defense response to Gram-negative bacterium [GO:0050829]; killing of cells of another organism [GO:0031640]	SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:12072414}. Note=Probably secreted into the epididymis lumen, where it localizes to the outer surface of sperm. Specifically localizes to the postacrosomal and tail regions of sperm. {ECO:0000269|PubMed:12072414}.
Q9H115	reviewed	SNAB_HUMAN	Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide-sensitive factor attachment protein beta)	NAPB SNAPB	Homo sapiens (Human)	298	FUNCTION: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. {ECO:0000250|UniProtKB:P28663}.		intracellular protein transport [GO:0006886]; regulation of synaptic vesicle priming [GO:0010807]; SNARE complex disassembly [GO:0035494]; synaptic transmission, glutamatergic [GO:0035249]	extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]	soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905]	extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]; soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905]; intracellular protein transport [GO:0006886]; regulation of synaptic vesicle priming [GO:0010807]; SNARE complex disassembly [GO:0035494]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q9H116	reviewed	GZF1_HUMAN	GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336)	GZF1 ZBTB23 ZNF336	Homo sapiens (Human)	711	FUNCTION: Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. {ECO:0000269|PubMed:14522971, ECO:0000269|PubMed:16049025}.		branching involved in ureteric bud morphogenesis [GO:0001658]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; branching involved in ureteric bud morphogenesis [GO:0001658]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14522971}. Nucleus, nucleoplasm {ECO:0000269|PubMed:14522971, ECO:0000269|PubMed:17674968}. Nucleus, nucleolus {ECO:0000269|PubMed:17674968}. Note=Nuclear localization depends upon NCL. {ECO:0000269|PubMed:17674968}.
Q9H147	reviewed	TDIF1_HUMAN	Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1) (TdIF1) (TdT-interacting factor 1)	DNTTIP1 C20orf167 TDIF1	Homo sapiens (Human)	329	FUNCTION: Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. {ECO:0000269|PubMed:11473582, ECO:0000269|PubMed:23874396, ECO:0000305|PubMed:25653165}.			chromosome [GO:0005694]; histone deacetylase complex [GO:0000118]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; nucleosome binding [GO:0031491]; protein homodimerization activity [GO:0042803]	chromosome [GO:0005694]; histone deacetylase complex [GO:0000118]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; nucleosome binding [GO:0031491]; protein homodimerization activity [GO:0042803]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11473582, ECO:0000269|PubMed:16371131}.
Q9H156	reviewed	SLIK2_HUMAN	SLIT and NTRK-like protein 2	SLITRK2 CXorf2 KIAA1854 SLITL1 UNQ9197/PRO34756	Homo sapiens (Human)	845	FUNCTION: It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Suppresses neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q810C0, ECO:0000269|PubMed:27273464, ECO:0000269|PubMed:27812321}.		axonogenesis [GO:0007409]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; regulation of synapse organization [GO:0050807]; synaptic membrane adhesion [GO:0099560]	GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]		GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; axonogenesis [GO:0007409]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; regulation of synapse organization [GO:0050807]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:27812321}.
Q9H159	reviewed	CAD19_HUMAN	Cadherin-19	CDH19 CDH7L2 UNQ478/PRO941	Homo sapiens (Human)	772	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q9H160	reviewed	ING2_HUMAN	Inhibitor of growth protein 2 (Inhibitor of growth 1-like protein) (ING1Lp) (p32) (p33ING2)	ING2 ING1L	Homo sapiens (Human)	280	FUNCTION: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). {ECO:0000269|PubMed:11481424, ECO:0000269|PubMed:12859901}.	MISCELLANEOUS: [Isoform ING2b]: Low expression except in testis, where it reaches half of ING2a levels. {ECO:0000305}.	DNA damage response [GO:0006974]; flagellated sperm motility [GO:0030317]; male germ-line stem cell asymmetric division [GO:0048133]; male meiosis I [GO:0007141]; negative regulation of cell migration [GO:0030336]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of cellular senescence [GO:2000772]; regulation of DNA-templated transcription [GO:0006355]; seminiferous tubule development [GO:0072520]; signal transduction [GO:0007165]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	CCAAT-binding factor complex [GO:0016602]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Sin3 complex [GO:0016580]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone deacetylase regulator activity [GO:0035033]; histone reader activity [GO:0140566]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; phosphatidylinositol binding [GO:0035091]; protein-containing complex binding [GO:0044877]	CCAAT-binding factor complex [GO:0016602]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Sin3 complex [GO:0016580]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone deacetylase regulator activity [GO:0035033]; histone reader activity [GO:0140566]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; phosphatidylinositol binding [GO:0035091]; protein-containing complex binding [GO:0044877]; DNA damage response [GO:0006974]; flagellated sperm motility [GO:0030317]; male germ-line stem cell asymmetric division [GO:0048133]; male meiosis I [GO:0007141]; negative regulation of cell migration [GO:0030336]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of cellular senescence [GO:2000772]; regulation of DNA-templated transcription [GO:0006355]; seminiferous tubule development [GO:0072520]; signal transduction [GO:0007165]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12859901}. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
Q9H161	reviewed	ALX4_HUMAN	Homeobox protein aristaless-like 4	ALX4 KIAA1788	Homo sapiens (Human)	411	FUNCTION: Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development. {ECO:0000269|PubMed:19692347}.		anterior/posterior pattern specification [GO:0009952]; digestive tract development [GO:0048565]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal system morphogenesis [GO:0048704]; hair follicle development [GO:0001942]; muscle organ development [GO:0007517]; post-embryonic development [GO:0009791]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; digestive tract development [GO:0048565]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal system morphogenesis [GO:0048704]; hair follicle development [GO:0001942]; muscle organ development [GO:0007517]; post-embryonic development [GO:0009791]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138, ECO:0000269|PubMed:19692347}.
Q9H165	reviewed	BC11A_HUMAN	B-cell lymphoma/leukemia 11A (BCL-11A) (B-cell CLL/lymphoma 11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856)	BCL11A CTIP1 EVI9 KIAA1809 ZNF856	Homo sapiens (Human)	835	FUNCTION: Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}.		cellular response to L-glutamate [GO:1905232]; negative regulation of axon extension [GO:0030517]; negative regulation of branching morphogenesis of a nerve [GO:2000173]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendrite development [GO:2000171]; negative regulation of dendrite extension [GO:1903860]; negative regulation of neuron projection development [GO:0010977]; negative regulation of neuron remodeling [GO:1904800]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]; regulation of dendrite development [GO:0050773]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; postsynapse [GO:0098794]; SWI/SNF complex [GO:0016514]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; transcription regulatory region nucleic acid binding [GO:0001067]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; postsynapse [GO:0098794]; SWI/SNF complex [GO:0016514]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; transcription regulatory region nucleic acid binding [GO:0001067]; cellular response to L-glutamate [GO:1905232]; negative regulation of axon extension [GO:0030517]; negative regulation of branching morphogenesis of a nerve [GO:2000173]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendrite development [GO:2000171]; negative regulation of dendrite extension [GO:1903860]; negative regulation of neuron projection development [GO:0010977]; negative regulation of neuron remodeling [GO:1904800]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]; regulation of dendrite development [GO:0050773]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11161790}. Nucleus {ECO:0000269|PubMed:11161790}. Chromosome {ECO:0000269|PubMed:29606353}. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus matrix {ECO:0000269|PubMed:16704730}. Note=Colocalizes with BCL6 in nuclear paraspeckles. {ECO:0000269|PubMed:16704730}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:27453576}. Nucleus {ECO:0000269|PubMed:27453576}. Note=Predominantly localized in the nucleus in nuclear paraspeckles. {ECO:0000269|PubMed:27453576}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:27453576}. Nucleus {ECO:0000269|PubMed:27453576}. Note=Predominantly localized in the cytoplasm in the absence of interaction with isoform 1 and isoform 2. In presence of isoform 1 or isoform 2, translocates from the cytoplasm into nuclear paraspeckles. {ECO:0000269|PubMed:27453576}.
Q9H169	reviewed	STMN4_HUMAN	Stathmin-4 (Stathmin-like protein B3) (RB3)	STMN4	Homo sapiens (Human)	189	FUNCTION: Exhibits microtubule-destabilizing activity. {ECO:0000250}.		microtubule depolymerization [GO:0007019]; neuron projection development [GO:0031175]; regulation of microtubule polymerization or depolymerization [GO:0031110]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005]	tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005]; tubulin binding [GO:0015631]; microtubule depolymerization [GO:0007019]; neuron projection development [GO:0031175]; regulation of microtubule polymerization or depolymerization [GO:0031110]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, axon {ECO:0000250}.
Q9H171	reviewed	ZBP1_HUMAN	Z-DNA-binding protein 1 (DNA-dependent activator of IFN-regulatory factors) (DAI) (Tumor stroma and activated macrophage protein DLM-1)	ZBP1 C20orf183 DLM1	Homo sapiens (Human)	429	FUNCTION: Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death (PubMed:32200799). ZBP1 acts as an essential mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, by activating RIPK3, caspase-8 (CASP8), and the NLRP3 inflammasome (By similarity). Key activator of necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, via its ability to bind Z-RNA: once activated upon Z-RNA-binding, ZBP1 interacts and stimulates RIPK3 kinase, which phosphorylates and activates MLKL, triggering execution of programmed necrosis (By similarity). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799). ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps (By similarity). In addition to its direct role in driving necroptosis via its ability to sense Z-RNAs, also involved in PANoptosis triggered in response to bacterial infection: component of the AIM2 PANoptosome complex, a multiprotein complex that triggers PANoptosis (By similarity). Also acts as the apical sensor of fungal infection responsible for activating PANoptosis (By similarity). Involved in CASP8-mediated cell death via its interaction with RIPK1 but independently of its ability to sense Z-RNAs (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). {ECO:0000250|UniProtKB:Q9QY24, ECO:0000269|PubMed:32200799}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms hetero-amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit ZBP1-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}.		activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; defense response to fungus [GO:0050832]; defense response to virus [GO:0051607]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inflammatory response [GO:0050729]; positive regulation of necroptotic process [GO:0060545]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; pyroptosis [GO:0070269]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-1-mediated signaling pathway [GO:2000659]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	DNA binding [GO:0003677]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; left-handed Z-DNA binding [GO:0003692]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; DNA binding [GO:0003677]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; left-handed Z-DNA binding [GO:0003692]; RNA binding [GO:0003723]; activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; defense response to fungus [GO:0050832]; defense response to virus [GO:0051607]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inflammatory response [GO:0050729]; positive regulation of necroptotic process [GO:0060545]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; pyroptosis [GO:0070269]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-1-mediated signaling pathway [GO:2000659]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16876127, ECO:0000269|PubMed:16990255}. Nucleus {ECO:0000269|PubMed:16876127, ECO:0000269|PubMed:16990255}. Note=Mainly cytoplasmic (PubMed:16876127, PubMed:16990255). Accumulates in the nucleus in response to influenza A virus (IAV) infection: senses IAV defective viral genomes RNA in the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9QY24, ECO:0000269|PubMed:16876127, ECO:0000269|PubMed:16990255}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm {ECO:0000269|PubMed:16876127, ECO:0000269|PubMed:16990255}. Nucleus {ECO:0000269|PubMed:16876127, ECO:0000269|PubMed:16990255}. Note=Compared to isoform 1, a higher proportion of this isoform is localized in the nucleus. {ECO:0000269|PubMed:16876127, ECO:0000269|PubMed:16990255}.
Q9H172	reviewed	ABCG4_HUMAN	ATP-binding cassette sub-family G member 4 (EC 7.6.2.-)	ABCG4 WHITE2	Homo sapiens (Human)	646	FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15240127, PubMed:33141061). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells (PubMed:27228027). {ECO:0000250|UniProtKB:Q91WA9, ECO:0000269|PubMed:15240127, ECO:0000269|PubMed:27228027, ECO:0000269|PubMed:33141061}.	MISCELLANEOUS: Whether ABCG4 is an LXR target gene, is still under debate. Studies performed in monocytes, and in one astrocyte cell line indicated that ABCG4 expression could be up-regulated by oxysterols and other LXR ligands (PubMed:11606068, PubMed:33141061). However, subsequent observations in a number of different cell types (primary mouse cells, oligodendrocytes and neuron-like cell lines) have not confirmed this observation (By similarity) (PubMed:33141061). {ECO:0000250|UniProtKB:Q91WA9, ECO:0000269|PubMed:11606068, ECO:0000269|PubMed:33141061}.	cellular response to high density lipoprotein particle stimulus [GO:0071403]; cellular response to leukemia inhibitory factor [GO:1990830]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol efflux [GO:0010875]; regulation of DNA-templated transcription [GO:0006355]; transmembrane transport [GO:0055085]	cytoplasmic vesicle [GO:0031410]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	ABC-type sterol transporter activity [GO:0034041]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytoplasmic vesicle [GO:0031410]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; ABC-type sterol transporter activity [GO:0034041]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; cellular response to high density lipoprotein particle stimulus [GO:0071403]; cellular response to leukemia inhibitory factor [GO:1990830]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol efflux [GO:0010875]; regulation of DNA-templated transcription [GO:0006355]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27228027}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q91WA9}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q91WA9}; Multi-pass membrane protein {ECO:0000255}.
Q9H173	reviewed	SIL1_HUMAN	Nucleotide exchange factor SIL1 (BiP-associated protein) (BAP)	SIL1 UNQ545/PRO836	Homo sapiens (Human)	461	FUNCTION: Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. {ECO:0000269|PubMed:12356756}.		cotranslational protein targeting to membrane [GO:0006613]; intracellular protein transport [GO:0006886]; protein folding [GO:0006457]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]	adenyl-nucleotide exchange factor activity [GO:0000774]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; adenyl-nucleotide exchange factor activity [GO:0000774]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082]; cotranslational protein targeting to membrane [GO:0006613]; intracellular protein transport [GO:0006886]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:12356756, ECO:0000269|PubMed:16282978}.
Q9H190	reviewed	SDCB2_HUMAN	Syntenin-2 (Similar to TACIP18) (SITAC) (Syndecan-binding protein 2)	SDCBP2 SITAC18	Homo sapiens (Human)	292	FUNCTION: Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997). {ECO:0000269|PubMed:15961997}.		cell population proliferation [GO:0008283]; intracellular signal transduction [GO:0035556]; intracellular transport [GO:0046907]; nervous system development [GO:0007399]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; cell population proliferation [GO:0008283]; intracellular signal transduction [GO:0035556]; intracellular transport [GO:0046907]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15961997}. Nucleus, nucleolus {ECO:0000269|PubMed:15961997, ECO:0000269|PubMed:23300061}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23300061}. Cell membrane {ECO:0000269|PubMed:15961997}. Nucleus speckle {ECO:0000269|PubMed:15961997}. Note=Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519). Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997). PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061). {ECO:0000269|PubMed:11102519, ECO:0000269|PubMed:15961997, ECO:0000269|PubMed:23300061}.
Q9H1A4	reviewed	APC1_HUMAN	Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein)	ANAPC1 TSG24	Homo sapiens (Human)	1944	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	molecular adaptor activity [GO:0060090]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; molecular adaptor activity [GO:0060090]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	
Q9H1B4	reviewed	NXF5_HUMAN	Nuclear RNA export factor 5 (TAP-like protein 1) (TAPL-1)	NXF5 TAPL1	Homo sapiens (Human)	397	FUNCTION: Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.	MISCELLANEOUS: [Isoform A]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; MISCELLANEOUS: [Isoform B]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform D]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform E]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA transport [GO:0050658]	cytoplasm [GO:0005737]; nuclear RNA export factor complex [GO:0042272]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear RNA export factor complex [GO:0042272]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA transport [GO:0050658]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm of cells and more particularly in the cell body and neurites of hippocampal neurons. Although nuclear localization is also observed. Not detected at nuclear rim.
Q9H1B5	reviewed	XYLT2_HUMAN	Xylosyltransferase 2 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase II) (XT-II) (XylT-II)	XYLT2 XT2 UNQ3058/PRO9878	Homo sapiens (Human)	865	FUNCTION: Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. {ECO:0000269|PubMed:17189265, ECO:0000269|PubMed:26027496}.		chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210]	extracellular space [GO:0005615]; Golgi membrane [GO:0000139]	magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein xylosyltransferase activity [GO:0030158]	extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein xylosyltransferase activity [GO:0030158]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:17189265, ECO:0000269|PubMed:25748573}.
Q9H1B7	reviewed	I2BPL_HUMAN	Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like)	IRF2BPL C14orf4 EAP1 KIAA1865 My039	Homo sapiens (Human)	796	FUNCTION: Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}.		development of secondary female sexual characteristics [GO:0046543]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]	extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; development of secondary female sexual characteristics [GO:0046543]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5EIC4}.
Q9H1C4	reviewed	UN93B_HUMAN	Protein unc-93 homolog B1 (Unc-93B1) (hUNC93B1)	UNC93B1 UNC93 UNC93B	Homo sapiens (Human)	597	FUNCTION: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. {ECO:0000269|PubMed:19006693}.		antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell morphogenesis [GO:0000902]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; T cell antigen processing and presentation [GO:0002457]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]	early phagosome [GO:0032009]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]	Toll-like receptor binding [GO:0035325]	early phagosome [GO:0032009]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; Toll-like receptor binding [GO:0035325]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell morphogenesis [GO:0000902]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; T cell antigen processing and presentation [GO:0002457]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity). Colocalizes with LAMP5 in large endosomal intracellular vesicles. {ECO:0000250, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}.
Q9H1D0	reviewed	TRPV6_HUMAN	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2)	TRPV6 ECAC2	Homo sapiens (Human)	765	FUNCTION: Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124, PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. {ECO:0000250|UniProtKB:Q91WD2, ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107}.		calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; parathyroid hormone secretion [GO:0035898]; regulation of calcium ion-dependent exocytosis [GO:0017158]; response to calcium ion [GO:0051592]	calcium channel complex [GO:0034704]; plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	calcium channel complex [GO:0034704]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; parathyroid hormone secretion [GO:0035898]; regulation of calcium ion-dependent exocytosis [GO:0017158]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107}; Multi-pass membrane protein {ECO:0000269|PubMed:29258289}.
Q9H1D9	reviewed	RPC6_HUMAN	DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) (RNA polymerase III 39 kDa subunit) (RPC39)	POLR3F	Homo sapiens (Human)	316	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus (PubMed:30211253). Acts as nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628). {ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:21358628, ECO:0000269|PubMed:30211253}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase III [GO:0006383]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]	DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; double-stranded DNA binding [GO:0003690]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; double-stranded DNA binding [GO:0003690]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9H1E1	reviewed	RNAS7_HUMAN	Ribonuclease 7 (RNase 7) (EC 3.1.27.-) (Skin-derived antimicrobial protein 2) (SAP-2)	RNASE7 UNQ2516/PRO6006	Homo sapiens (Human)	156	FUNCTION: Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms including uropathogenic E.coli (UPEC), and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:25075772, PubMed:33818125, PubMed:17150966). Causes loss of bacterial membrane integrity (PubMed:17150966). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:17150966). {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:12527768, ECO:0000269|PubMed:17150966, ECO:0000269|PubMed:25075772, ECO:0000269|PubMed:33818125}.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytolysis in another organism [GO:0051715]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	endonuclease activity [GO:0004519]; lipopolysaccharide binding [GO:0001530]; nucleic acid binding [GO:0003676]; peptidoglycan binding [GO:0042834]; RNA nuclease activity [GO:0004540]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; endonuclease activity [GO:0004519]; lipopolysaccharide binding [GO:0001530]; nucleic acid binding [GO:0003676]; peptidoglycan binding [GO:0042834]; RNA nuclease activity [GO:0004540]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytolysis in another organism [GO:0051715]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:25075772}. Note=Detected in urine. {ECO:0000269|PubMed:25075772}.
Q9H1E3	reviewed	NUCKS_HUMAN	Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1)	NUCKS1 NUCKS JC7	Homo sapiens (Human)	243	FUNCTION: Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}.		cellular response to X-ray [GO:0071481]; chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; gene conversion [GO:0035822]; interstrand cross-link repair [GO:0036297]; intracellular glucose homeostasis [GO:0001678]; modulation by host of RNA binding by virus [GO:1990968]; modulation by host of viral genome replication [GO:0044827]; modulation by host of viral RNA-binding transcription factor activity [GO:1990969]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of insulin receptor signaling pathway [GO:0046626]; replication fork processing [GO:0031297]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713]; cellular response to X-ray [GO:0071481]; chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; gene conversion [GO:0035822]; interstrand cross-link repair [GO:0036297]; intracellular glucose homeostasis [GO:0001678]; modulation by host of RNA binding by virus [GO:1990968]; modulation by host of viral genome replication [GO:0044827]; modulation by host of viral RNA-binding transcription factor activity [GO:1990969]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of insulin receptor signaling pathway [GO:0046626]; replication fork processing [GO:0031297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11298763, ECO:0000269|PubMed:26323318}. Chromosome {ECO:0000269|PubMed:26323318}.
Q9H1H9	reviewed	KI13A_HUMAN	Kinesin-like protein KIF13A (Kinesin-like protein RBKIN)	KIF13A RBKIN	Homo sapiens (Human)	1805	FUNCTION: Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cytoskeleton-dependent intracellular transport [GO:0030705]; endosome to lysosome transport [GO:0008333]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; melanosome organization [GO:0032438]; microtubule-based movement [GO:0007018]; plus-end-directed vesicle transport along microtubule [GO:0072383]; regulation of cytokinesis [GO:0032465]; vesicle cargo loading [GO:0035459]	centrosome [GO:0005813]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; trans-Golgi network membrane [GO:0032588]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	centrosome [GO:0005813]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; trans-Golgi network membrane [GO:0032588]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; cell cycle [GO:0007049]; cell division [GO:0051301]; cytoskeleton-dependent intracellular transport [GO:0030705]; endosome to lysosome transport [GO:0008333]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; melanosome organization [GO:0032438]; microtubule-based movement [GO:0007018]; plus-end-directed vesicle transport along microtubule [GO:0072383]; regulation of cytokinesis [GO:0032465]; vesicle cargo loading [GO:0035459]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane {ECO:0000250}. Note=Recruited to the midbody during cytokinesis.
Q9H1I8	reviewed	ASCC2_HUMAN	Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100)	ASCC2 ASC1P100 RQT3	Homo sapiens (Human)	757	FUNCTION: Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32579943, PubMed:32099016, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32579943, PubMed:32099016, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}.		DNA dealkylation involved in DNA repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; regulation of DNA-templated transcription [GO:0006355]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	activating signal cointegrator 1 complex [GO:0099053]; cytosolic ribosome [GO:0022626]; DNA repair complex [GO:1990391]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; ubiquitin binding [GO:0043130]	activating signal cointegrator 1 complex [GO:0099053]; cytosolic ribosome [GO:0022626]; DNA repair complex [GO:1990391]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; ubiquitin binding [GO:0043130]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; regulation of DNA-templated transcription [GO:0006355]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:26924529, ECO:0000269|PubMed:29144457}. Nucleus speckle {ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:29997253}. Note=Colocalizes with the spliceosomal components PRPF8 and SNRNP200/BRR2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Colocalizes with RNF113A and 'Lys-63'-linked polyubiquitinated proteins, ALKBH3 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. {ECO:0000269|PubMed:29144457}.
Q9H1J1	reviewed	REN3A_HUMAN	Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3)	UPF3A RENT3A UPF3	Homo sapiens (Human)	476	FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}.		in utero embryonic development [GO:0001701]; mRNA transport [GO:0051028]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; positive regulation of translation [GO:0045727]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; telomeric DNA binding [GO:0042162]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; telomeric DNA binding [GO:0042162]; in utero embryonic development [GO:0001701]; mRNA transport [GO:0051028]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; positive regulation of translation [GO:0045727]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11163187}. Cytoplasm {ECO:0000269|PubMed:11163187}. Note=Shuttling between the nucleus and the cytoplasm. {ECO:0000269|PubMed:11163187}.
Q9H1J5	reviewed	WNT8A_HUMAN	Protein Wnt-8a (Protein Wnt-8d)	WNT8A WNT8D	Homo sapiens (Human)	351	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. {ECO:0000250|UniProtKB:P51028}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	anterior/posterior axis specification [GO:0009948]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [GO:0061317]; canonical Wnt signaling pathway involved in neural crest cell differentiation [GO:0044335]; cell fate commitment [GO:0045165]; neural crest cell fate commitment [GO:0014034]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to retinoic acid [GO:0032526]; secondary palate development [GO:0062009]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; anterior/posterior axis specification [GO:0009948]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [GO:0061317]; canonical Wnt signaling pathway involved in neural crest cell differentiation [GO:0044335]; cell fate commitment [GO:0045165]; neural crest cell fate commitment [GO:0014034]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to retinoic acid [GO:0032526]; secondary palate development [GO:0062009]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
Q9H1J7	reviewed	WNT5B_HUMAN	Protein Wnt-5b	WNT5B	Homo sapiens (Human)	359	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}.		canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; fat cell differentiation [GO:0045444]; lens fiber cell development [GO:0070307]; muscle cell differentiation [GO:0042692]; neuron differentiation [GO:0030182]; positive regulation of cell migration [GO:0030335]; positive regulation of convergent extension involved in gastrulation [GO:1904105]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]	endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; signaling receptor binding [GO:0005102]	endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; signaling receptor binding [GO:0005102]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; fat cell differentiation [GO:0045444]; lens fiber cell development [GO:0070307]; muscle cell differentiation [GO:0042692]; neuron differentiation [GO:0030182]; positive regulation of cell migration [GO:0030335]; positive regulation of convergent extension involved in gastrulation [GO:1904105]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q9H1K0	reviewed	RBNS5_HUMAN	Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20)	RBSN ZFYVE20	Homo sapiens (Human)	784	FUNCTION: Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}.		early endosome to Golgi transport [GO:0034498]; endosomal transport [GO:0016197]; Golgi to lysosome transport [GO:0090160]; protein transport [GO:0015031]; regulation of Golgi organization [GO:1903358]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]; early endosome to Golgi transport [GO:0034498]; endosomal transport [GO:0016197]; Golgi to lysosome transport [GO:0090160]; protein transport [GO:0015031]; regulation of Golgi organization [GO:1903358]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane {ECO:0000269|PubMed:22308388}; Lipid-anchor. Note=Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface. {ECO:0000269|PubMed:22308388}.
Q9H1K1	reviewed	ISCU_HUMAN	Iron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein)	ISCU NIFUN	Homo sapiens (Human)	167	FUNCTION: [Isoform 1]: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled (PubMed:34824239). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (PubMed:30031876, PubMed:34824239, PubMed:24971490, PubMed:29576242) (Probable). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form (PubMed:23940031). May modulate NFS1 desulfurase activity in a zinc-dependent manner (PubMed:30031876). Modulates the interaction between FXN and the cysteine desulfurase complex (PubMed:29576242). {ECO:0000269|PubMed:23940031, ECO:0000269|PubMed:24971490, ECO:0000269|PubMed:29576242, ECO:0000269|PubMed:30031876, ECO:0000269|PubMed:34824239, ECO:0000305|PubMed:23940031}.; FUNCTION: [Isoform 2]: Cytoplasmic scaffold protein, of the cytoplasmic core iron-sulfur cluster (ISC) assembly complex that provides the structural architecture on which the Fe-S clusters are assembled and may be involved in the cytoplasmic iron-sulfur protein biogenesis. {ECO:0000269|PubMed:16517407, ECO:0000269|PubMed:16527810, ECO:0000269|PubMed:29309586}.		[2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of iron ion import across plasma membrane [GO:1904439]; positive regulation of aconitate hydratase activity [GO:1904234]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial iron-sulfur cluster assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	2 iron, 2 sulfur cluster binding [GO:0051537]; ferrous iron binding [GO:0008198]; iron ion binding [GO:0005506]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial iron-sulfur cluster assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; 2 iron, 2 sulfur cluster binding [GO:0051537]; ferrous iron binding [GO:0008198]; iron ion binding [GO:0005506]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; [2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of iron ion import across plasma membrane [GO:1904439]; positive regulation of aconitate hydratase activity [GO:1904234]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:11060020, ECO:0000269|PubMed:26702583}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus {ECO:0000269|PubMed:11060020}.
Q9H1K4	reviewed	GHC2_HUMAN	Mitochondrial glutamate carrier 2 (GC-2) (Glutamate/H(+) symporter 2) (Solute carrier family 25 member 18)	SLC25A18 GC2	Homo sapiens (Human)	315	FUNCTION: Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system). {ECO:0000269|PubMed:11897791}.		aspartate transmembrane transport [GO:0015810]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; monoatomic ion transport [GO:0006811]	mitochondrial inner membrane [GO:0005743]	amino acid:proton symporter activity [GO:0005280]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]	mitochondrial inner membrane [GO:0005743]; amino acid:proton symporter activity [GO:0005280]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; aspartate transmembrane transport [GO:0015810]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; monoatomic ion transport [GO:0006811]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q505J6}; Multi-pass membrane protein {ECO:0000255}.
Q9H1M4	reviewed	DB127_HUMAN	Beta-defensin 127 (Beta-defensin 27) (DEFB-27) (Defensin, beta 127)	DEFB127 C20orf73 DEFB27 UNQ1956/PRO6071	Homo sapiens (Human)	99	FUNCTION: Has antibacterial activity. {ECO:0000305}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H1N7	reviewed	S35B3_HUMAN	Adenosine 3'-phospho 5'-phosphosulfate transporter 2 (3'-phosphoadenosine 5'-phosphosulfate transporter) (PAPS transporter 2) (Solute carrier family 35 member B3)	SLC35B3 C6orf196 PAPST2 CGI-19	Homo sapiens (Human)	401	FUNCTION: Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment. {ECO:0000269|PubMed:16492677}.		5'-adenylyl sulfate transmembrane transport [GO:1902558]	Golgi membrane [GO:0000139]	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964]; antiporter activity [GO:0015297]	Golgi membrane [GO:0000139]; 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964]; antiporter activity [GO:0015297]; 5'-adenylyl sulfate transmembrane transport [GO:1902558]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16492677}; Multi-pass membrane protein {ECO:0000255}.
Q9H1P3	reviewed	OSBL2_HUMAN	Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)	OSBPL2 KIAA0772 ORP2	Homo sapiens (Human)	480	FUNCTION: Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane (PubMed:30581148). Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate (PubMed:30581148). Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro) (PubMed:17428193, PubMed:19224871, PubMed:30581148). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19224871, ECO:0000269|PubMed:30581148}.		bile acid biosynthetic process [GO:0006699]; cholesterol transport [GO:0030301]; intracellular cholesterol transport [GO:0032367]; phospholipid transport [GO:0015914]; plasma membrane organization [GO:0007009]; protein homotetramerization [GO:0051289]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; phosphatidylinositol transfer activity [GO:0008526]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; sterol transporter activity [GO:0015248]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; phosphatidylinositol transfer activity [GO:0008526]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; sterol transporter activity [GO:0015248]; bile acid biosynthetic process [GO:0006699]; cholesterol transport [GO:0030301]; intracellular cholesterol transport [GO:0032367]; phospholipid transport [GO:0015914]; plasma membrane organization [GO:0007009]; protein homotetramerization [GO:0051289]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19224871, ECO:0000269|PubMed:30581148}. Lipid droplet {ECO:0000269|PubMed:19224871}. Cell membrane {ECO:0000269|PubMed:30581148}; Peripheral membrane protein {ECO:0000269|PubMed:30581148}; Cytoplasmic side {ECO:0000269|PubMed:30581148}. Note=Detected on the surface of cytosolic lipid droplets (PubMed:19224871). Recruited to the cell membrane by phosphatidylinositol-phosphate binding (PubMed:30581148). {ECO:0000269|PubMed:19224871, ECO:0000269|PubMed:30581148}.
Q9H1P6	reviewed	CMIP1_HUMAN	Ciliary microtubule inner protein 1	CIMIP1 C20orf85 LLC1	Homo sapiens (Human)	137				cilium [GO:0005929]		cilium [GO:0005929]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:25786037}.
Q9H1R2	reviewed	DUS15_HUMAN	Dual specificity protein phosphatase 15 (EC 3.1.3.16) (EC 3.1.3.48) (VH1-related member Y) (Vaccinia virus VH1-related dual-specific protein phosphatase Y)	DUSP15 C20orf57 VHY	Homo sapiens (Human)	295	FUNCTION: May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334). {ECO:0000269|PubMed:22792334}.; FUNCTION: [Isoform 3]: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity). {ECO:0000250|UniProtKB:B4F7B7, ECO:0000250|UniProtKB:Q8R4V2}.		dephosphorylation [GO:0016311]; regulation of oligodendrocyte differentiation [GO:0048713]; signal transduction [GO:0007165]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; dephosphorylation [GO:0016311]; regulation of oligodendrocyte differentiation [GO:0048713]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:15138252}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Lipid-anchor; Cytoplasmic side.
Q9H1R3	reviewed	MYLK2_HUMAN	Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18)	MYLK2	Homo sapiens (Human)	596	FUNCTION: Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}.		cardiac muscle contraction [GO:0060048]; cardiac muscle tissue morphogenesis [GO:0055008]; neuromuscular synaptic transmission [GO:0007274]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of gene expression [GO:0010628]; protein autophosphorylation [GO:0046777]; regulation of muscle filament sliding [GO:0032971]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle satellite cell differentiation [GO:0014816]; striated muscle contraction [GO:0006941]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; sarcomere [GO:0030017]; synapse [GO:0045202]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; myosin light chain binding [GO:0032027]; myosin light chain kinase activity [GO:0004687]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; sarcomere [GO:0030017]; synapse [GO:0045202]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; myosin light chain binding [GO:0032027]; myosin light chain kinase activity [GO:0004687]; cardiac muscle contraction [GO:0060048]; cardiac muscle tissue morphogenesis [GO:0055008]; neuromuscular synaptic transmission [GO:0007274]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of gene expression [GO:0010628]; protein autophosphorylation [GO:0046777]; regulation of muscle filament sliding [GO:0032971]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle satellite cell differentiation [GO:0014816]; striated muscle contraction [GO:0006941]	SUBCELLULAR LOCATION: Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
Q9H1U9	reviewed	S2551_HUMAN	Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 (Mitochondrial NAD(+) transporter SLC25A51) (Mitochondrial carrier triple repeat protein 1) (Solute carrier family 25 member 51)	SLC25A51 MCART1	Homo sapiens (Human)	297	FUNCTION: Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria (PubMed:32906142, PubMed:33262325, PubMed:33087354). Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration (PubMed:32906142, PubMed:33262325, PubMed:33087354). Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria (PubMed:32906142). The transport mechanism, uniport or antiport, its electrogenicity and substrate selectivity, remain to be elucidated. {ECO:0000269|PubMed:32906142, ECO:0000269|PubMed:33262325}.		aerobic electron transport chain [GO:0019646]; mitochondrial NAD transmembrane transport [GO:1990549]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	NAD transmembrane transporter activity [GO:0051724]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; NAD transmembrane transporter activity [GO:0051724]; aerobic electron transport chain [GO:0019646]; mitochondrial NAD transmembrane transport [GO:1990549]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:33087354, ECO:0000305|PubMed:32906142}; Multi-pass membrane protein {ECO:0000255}.
Q9H1V8	reviewed	S6A17_HUMAN	Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17)	SLC6A17 NTT4	Homo sapiens (Human)	727	FUNCTION: Synaptic vesicle transporter with apparent selectivity for neutral amino acids. The transport is sodium-coupled but chloride-independent, likely driven by the proton electrochemical gradient generated by vacuolar H(+)-ATPase in an overall electrogenic mechanism. May contribute to the synaptic uptake of neurotransmitter precursors in a process coupled in part to vesicle exocytosis. {ECO:0000250|UniProtKB:P31662}.		alanine transport [GO:0032328]; brain development [GO:0007420]; glycine transport [GO:0015816]; leucine transport [GO:0015820]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; proline transport [GO:0015824]; protein catabolic process [GO:0030163]; sodium ion transmembrane transport [GO:0035725]; transport across blood-brain barrier [GO:0150104]	cell projection [GO:0042995]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	symporter activity [GO:0015293]	cell projection [GO:0042995]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; symporter activity [GO:0015293]; alanine transport [GO:0032328]; brain development [GO:0007420]; glycine transport [GO:0015816]; leucine transport [GO:0015820]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; proline transport [GO:0015824]; protein catabolic process [GO:0030163]; sodium ion transmembrane transport [GO:0035725]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P31662}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31662}. Postsynapse {ECO:0000250|UniProtKB:Q8BJI1}. Presynapse {ECO:0000250|UniProtKB:Q8BJI1}. Note=Localizes at synaptic junctions - at both pre- and post-synaptic sites - particularly in excitatory glutamatergic terminals. {ECO:0000250|UniProtKB:Q8BJI1}.
Q9H1X1	reviewed	RSPH9_HUMAN	Radial spoke head protein 9 homolog	RSPH9 C6orf206 MRPS18AL1	Homo sapiens (Human)	276	FUNCTION: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (PubMed:19200523). Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (By similarity). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (By similarity). {ECO:0000250|UniProtKB:Q5TYW6, ECO:0000250|UniProtKB:Q9D9V4, ECO:0000269|PubMed:19200523}.		axonemal central apparatus assembly [GO:1904158]; axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; motile cilium assembly [GO:0044458]; radial spoke assembly [GO:0062177]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; kinocilium [GO:0060091]; motile cilium [GO:0031514]; radial spoke head 1 [GO:0120336]; radial spoke head 3 [GO:0120338]; sperm flagellum [GO:0036126]		9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; kinocilium [GO:0060091]; motile cilium [GO:0031514]; radial spoke head 1 [GO:0120336]; radial spoke head 3 [GO:0120338]; sperm flagellum [GO:0036126]; axonemal central apparatus assembly [GO:1904158]; axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; motile cilium assembly [GO:0044458]; radial spoke assembly [GO:0062177]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9D9V4}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9D9V4}. Cell projection, kinocilium {ECO:0000250|UniProtKB:Q5TYW6}.
Q9H1Y0	reviewed	ATG5_HUMAN	Autophagy protein 5 (APG5-like) (Apoptosis-specific protein)	ATG5 APG5L ASP	Homo sapiens (Human)	275	FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. {ECO:0000250|UniProtKB:Q99J83, ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:20580051, ECO:0000269|PubMed:22170153, ECO:0000269|PubMed:26812546}.; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. {ECO:0000269|PubMed:15778222, ECO:0000269|PubMed:7796880}.; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601). {ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:19666601}.		aggrephagy [GO:0035973]; antigen processing and presentation of endogenous antigen [GO:0019883]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; blood vessel remodeling [GO:0001974]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to nitrogen starvation [GO:0006995]; cellular response to nitrosative stress [GO:0071500]; chaperone-mediated autophagy [GO:0061684]; chromatin organization [GO:0006325]; establishment of localization in cell [GO:0051649]; heart contraction [GO:0060047]; macroautophagy [GO:0016236]; mucus secretion [GO:0070254]; negative regulation of autophagic cell death [GO:1904093]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of defense response to virus [GO:0050687]; negative regulation of innate immune response [GO:0045824]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of type I interferon production [GO:0032480]; negative stranded viral RNA replication [GO:0039689]; negative thymic T cell selection [GO:0045060]; nucleophagy [GO:0044804]; otolith development [GO:0048840]; positive regulation of mucus secretion [GO:0070257]; positive regulation of viral translation [GO:1904973]; post-translational protein modification [GO:0043687]; protein ubiquitination [GO:0016567]; regulation of autophagosome maturation [GO:1901096]; regulation of cilium assembly [GO:1902017]; regulation of cytokine production involved in immune response [GO:0002718]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; response to fluoride [GO:1902617]; response to fungus [GO:0009620]; response to iron(II) ion [GO:0010040]; response to xenobiotic stimulus [GO:0009410]; vasodilation [GO:0042311]; ventricular cardiac muscle cell development [GO:0055015]	Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome [GO:0005776]; axon [GO:0030424]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site membrane [GO:0034045]; protein-containing complex [GO:0032991]; transferase complex [GO:1990234]	Atg8-family ligase activity [GO:0019776]	Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome [GO:0005776]; axon [GO:0030424]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site membrane [GO:0034045]; protein-containing complex [GO:0032991]; transferase complex [GO:1990234]; Atg8-family ligase activity [GO:0019776]; aggrephagy [GO:0035973]; antigen processing and presentation of endogenous antigen [GO:0019883]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; blood vessel remodeling [GO:0001974]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to nitrogen starvation [GO:0006995]; cellular response to nitrosative stress [GO:0071500]; chaperone-mediated autophagy [GO:0061684]; chromatin organization [GO:0006325]; establishment of localization in cell [GO:0051649]; heart contraction [GO:0060047]; macroautophagy [GO:0016236]; mucus secretion [GO:0070254]; negative regulation of autophagic cell death [GO:1904093]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of defense response to virus [GO:0050687]; negative regulation of innate immune response [GO:0045824]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of type I interferon production [GO:0032480]; negative stranded viral RNA replication [GO:0039689]; negative thymic T cell selection [GO:0045060]; nucleophagy [GO:0044804]; otolith development [GO:0048840]; positive regulation of mucus secretion [GO:0070257]; positive regulation of viral translation [GO:1904973]; post-translational protein modification [GO:0043687]; protein ubiquitination [GO:0016567]; regulation of autophagosome maturation [GO:1901096]; regulation of cilium assembly [GO:1902017]; regulation of cytokine production involved in immune response [GO:0002718]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; response to fluoride [GO:1902617]; response to fungus [GO:0009620]; response to iron(II) ion [GO:0010040]; response to xenobiotic stimulus [GO:0009410]; vasodilation [GO:0042311]; ventricular cardiac muscle cell development [GO:0055015]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17709747}. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
Q9H1Y3	reviewed	OPN3_HUMAN	Opsin-3 (Encephalopsin) (Panopsin)	OPN3 ECPN	Homo sapiens (Human)	402	FUNCTION: G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin (PubMed:28842328, PubMed:31380578, PubMed:31097585). Binds both 11-cis retinal and all-trans retinal (PubMed:31097585). Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R-mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light (PubMed:28842328, PubMed:31097585). Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling (PubMed:31730232). Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade (PubMed:31730232). Required for TYR and DCT blue light-induced complex formation in melanocytes (PubMed:28842328). Involved in keratinocyte differentiation in response to blue-light (PubMed:30168605). Required for the UVA-mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (PubMed:31380578). Plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (By similarity). May be involved in photorelaxation of airway smooth muscle cells, via blue-light dependent GPCR signaling pathways (By similarity). {ECO:0000250|UniProtKB:Q9WUK7, ECO:0000269|PubMed:28842328, ECO:0000269|PubMed:30168605, ECO:0000269|PubMed:31097585, ECO:0000269|PubMed:31380578, ECO:0000269|PubMed:31730232}.		cellular response to light stimulus [GO:0071482]; cellular response to UV-A [GO:0071492]; detection of light stimulus [GO:0009583]; G protein-coupled receptor signaling pathway [GO:0007186]; keratinocyte differentiation [GO:0030216]; negative regulation of apoptotic process [GO:0043066]; negative regulation of melanin biosynthetic process [GO:0048022]; phototransduction [GO:0007602]; positive regulation of cellular respiration [GO:1901857]; positive regulation of glucose import [GO:0046326]; positive regulation of melanin biosynthetic process [GO:0048023]; regulation of circadian rhythm [GO:0042752]; response to blue light [GO:0009637]	cytoplasm [GO:0005737]; membrane [GO:0016020]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]	11-cis retinal binding [GO:0005502]; all-trans retinal binding [GO:0005503]; G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]; photoreceptor activity [GO:0009881]	cytoplasm [GO:0005737]; membrane [GO:0016020]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; 11-cis retinal binding [GO:0005502]; all-trans retinal binding [GO:0005503]; G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]; photoreceptor activity [GO:0009881]; cellular response to light stimulus [GO:0071482]; cellular response to UV-A [GO:0071492]; detection of light stimulus [GO:0009583]; G protein-coupled receptor signaling pathway [GO:0007186]; keratinocyte differentiation [GO:0030216]; negative regulation of apoptotic process [GO:0043066]; negative regulation of melanin biosynthetic process [GO:0048022]; phototransduction [GO:0007602]; positive regulation of cellular respiration [GO:1901857]; positive regulation of glucose import [GO:0046326]; positive regulation of melanin biosynthetic process [GO:0048023]; regulation of circadian rhythm [GO:0042752]; response to blue light [GO:0009637]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30168605, ECO:0000269|PubMed:31097585, ECO:0000269|PubMed:31380578, ECO:0000269|PubMed:31730232}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:30168605}.
Q9H201	reviewed	EPN3_HUMAN	Epsin-3 (EPS-15-interacting protein 3)	EPN3	Homo sapiens (Human)	632		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	endocytosis [GO:0006897]	clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasmic side of plasma membrane [GO:0009898]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	clathrin binding [GO:0030276]; EH domain binding [GO:1990175]; phospholipid binding [GO:0005543]	clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasmic side of plasma membrane [GO:0009898]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; clathrin binding [GO:0030276]; EH domain binding [GO:1990175]; phospholipid binding [GO:0005543]; endocytosis [GO:0006897]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11359770}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11359770}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:11359770}. Nucleus {ECO:0000305|PubMed:11359770}. Note=Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the cell periphery. May shuttle to the nucleus.
Q9H204	reviewed	MED28_HUMAN	Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)	MED28 EG1 FKSG20	Homo sapiens (Human)	178	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. {ECO:0000269|PubMed:15467741}.		negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]	core mediator complex [GO:0070847]; cortical actin cytoskeleton [GO:0030864]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	actin binding [GO:0003779]	core mediator complex [GO:0070847]; cortical actin cytoskeleton [GO:0030864]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; actin binding [GO:0003779]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15467741}. Cytoplasm {ECO:0000269|PubMed:15467741}. Membrane {ECO:0000269|PubMed:15467741}; Peripheral membrane protein {ECO:0000269|PubMed:15467741}. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.
Q9H211	reviewed	CDT1_HUMAN	DNA replication factor Cdt1 (Double parked homolog) (DUP)	CDT1	Homo sapiens (Human)	546	FUNCTION: Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}.		attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; DNA replication checkpoint signaling [GO:0000076]; DNA replication preinitiation complex assembly [GO:0071163]; mitotic cell cycle [GO:0000278]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated DNA replication [GO:2000104]; positive regulation of chromatin binding [GO:0035563]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated DNA replication [GO:2000105]; regulation of DNA replication origin binding [GO:1902595]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of nuclear cell cycle DNA replication [GO:0033262]; response to sorbitol [GO:0072708]	kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]	kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; DNA replication checkpoint signaling [GO:0000076]; DNA replication preinitiation complex assembly [GO:0071163]; mitotic cell cycle [GO:0000278]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated DNA replication [GO:2000104]; positive regulation of chromatin binding [GO:0035563]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated DNA replication [GO:2000105]; regulation of DNA replication origin binding [GO:1902595]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of nuclear cell cycle DNA replication [GO:0033262]; response to sorbitol [GO:0072708]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:26842564}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:22581055}. Note=Transiently localizes to kinetochores during prometaphase and metaphase. {ECO:0000269|PubMed:22581055}.
Q9H221	reviewed	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8 (EC 7.6.2.-) (Sterolin-2)	ABCG8	Homo sapiens (Human)	673	FUNCTION: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356). {ECO:0000269|PubMed:11099417, ECO:0000269|PubMed:11452359, ECO:0000269|PubMed:15054092, ECO:0000269|PubMed:16893193, ECO:0000269|PubMed:27144356}.	MISCELLANEOUS: [Isoform 2]: Minor form detected in approximately 10% of the cDNA clones. {ECO:0000305}.	bile acid signaling pathway [GO:0038183]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; intestinal cholesterol absorption [GO:0030299]; negative regulation of intestinal cholesterol absorption [GO:0045796]; negative regulation of intestinal phytosterol absorption [GO:0010949]; phospholipid transport [GO:0015914]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; sterol transport [GO:0015918]; transmembrane transport [GO:0055085]; triglyceride homeostasis [GO:0070328]	apical plasma membrane [GO:0016324]; ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]	apical plasma membrane [GO:0016324]; ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; bile acid signaling pathway [GO:0038183]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; intestinal cholesterol absorption [GO:0030299]; negative regulation of intestinal cholesterol absorption [GO:0045796]; negative regulation of intestinal phytosterol absorption [GO:0010949]; phospholipid transport [GO:0015914]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; sterol transport [GO:0015918]; transmembrane transport [GO:0055085]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:16893193}; Multi-pass membrane protein {ECO:0000269|PubMed:27144356}. Apical cell membrane {ECO:0000269|PubMed:14504269}; Multi-pass membrane protein {ECO:0000269|PubMed:27144356}.
Q9H222	reviewed	ABCG5_HUMAN	ATP-binding cassette sub-family G member 5 (EC 7.6.2.-) (Sterolin-1)	ABCG5	Homo sapiens (Human)	651	FUNCTION: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356). Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11138003, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11138003, PubMed:15054092). The heterodimer with ABCG8 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356). {ECO:0000269|PubMed:11138003, ECO:0000269|PubMed:15054092, ECO:0000269|PubMed:16893193, ECO:0000269|PubMed:20210363, ECO:0000269|PubMed:27144356, ECO:0000303|PubMed:11590207, ECO:0000305|PubMed:11099417}.		bile acid signaling pathway [GO:0038183]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; intestinal cholesterol absorption [GO:0030299]; negative regulation of intestinal cholesterol absorption [GO:0045796]; negative regulation of intestinal phytosterol absorption [GO:0010949]; response to ionizing radiation [GO:0010212]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; sterol transport [GO:0015918]; transmembrane transport [GO:0055085]; triglyceride homeostasis [GO:0070328]	apical plasma membrane [GO:0016324]; ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]	apical plasma membrane [GO:0016324]; ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; bile acid signaling pathway [GO:0038183]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; intestinal cholesterol absorption [GO:0030299]; negative regulation of intestinal cholesterol absorption [GO:0045796]; negative regulation of intestinal phytosterol absorption [GO:0010949]; response to ionizing radiation [GO:0010212]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; sterol transport [GO:0015918]; transmembrane transport [GO:0055085]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:16893193, ECO:0000305|PubMed:27144356}; Multi-pass membrane protein {ECO:0000269|PubMed:27144356}. Apical cell membrane {ECO:0000269|PubMed:14504269}; Multi-pass membrane protein {ECO:0000269|PubMed:27144356}.
Q9H223	reviewed	EHD4_HUMAN	EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4)	EHD4 HCA10 HCA11 PAST4 FKSG7	Homo sapiens (Human)	541	FUNCTION: ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport. {ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:18331452}.		cellular response to growth factor stimulus [GO:0071363]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; pinocytosis [GO:0006907]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; regulation of endocytosis [GO:0030100]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; nucleic acid binding [GO:0003676]; cellular response to growth factor stimulus [GO:0071363]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; pinocytosis [GO:0006907]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; regulation of endocytosis [GO:0030100]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:18331452}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Recycling endosome membrane {ECO:0000269|PubMed:18331452}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q9EQP2}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q9H227	reviewed	GBA3_HUMAN	Cytosolic beta-glucosidase (EC 3.2.1.21) (Cytosolic beta-glucosidase-like protein 1) (Cytosolic galactosylceramidase) (EC 3.2.1.46) (Cytosolic glucosylceramidase) (EC 3.2.1.45) (Cytosolic glycosylceramidase) (Cytosolic GCase) (Glucosidase beta acid 3) (Glucosylceramidase beta 3) (Klotho-related protein) (KLrP)	GBA3 CBG CBGL1	Homo sapiens (Human)	469	FUNCTION: Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (PubMed:11389701, PubMed:11784319, PubMed:20728381, PubMed:26724485, PubMed:17595169, PubMed:33361282). Has a significant glucosylceramidase activity in vitro (PubMed:26724485, PubMed:17595169). However, that activity is relatively low and its significance in vivo is not clear (PubMed:26724485, PubMed:17595169, PubMed:20728381). Hydrolyzes galactosylceramides/GalCers, glucosylsphingosines/GlcSphs and galactosylsphingosines/GalSphs (PubMed:17595169). However, the in vivo relevance of these activities is unclear (PubMed:17595169). It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics (PubMed:11784319). Possesses transxylosylase activity in vitro using xylosylated ceramides/XylCers (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) as xylosyl donors and cholesterol as acceptor (PubMed:33361282). Could also play a role in the catabolism of cytosolic sialyl free N-glycans (PubMed:26193330). {ECO:0000269|PubMed:11389701, ECO:0000269|PubMed:11784319, ECO:0000269|PubMed:17595169, ECO:0000269|PubMed:20728381, ECO:0000269|PubMed:26193330, ECO:0000269|PubMed:26724485, ECO:0000269|PubMed:33361282}.		beta-glucoside catabolic process [GO:1901805]; galactosylceramide catabolic process [GO:0006683]; glucosylceramide catabolic process [GO:0006680]; glycoside catabolic process [GO:0016139]; glycosphingolipid metabolic process [GO:0006687]; glycosylceramide catabolic process [GO:0046477]; oligosaccharide catabolic process [GO:0009313]; positive regulation of exo-alpha-sialidase activity [GO:1903017]; protein stabilization [GO:0050821]	catalytic complex [GO:1902494]; cytosol [GO:0005829]	beta-galactosidase activity [GO:0004565]; beta-glucosidase activity [GO:0008422]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glycosylceramidase activity [GO:0017042]; scopolin beta-glucosidase activity [GO:0102483]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; beta-galactosidase activity [GO:0004565]; beta-glucosidase activity [GO:0008422]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glycosylceramidase activity [GO:0017042]; scopolin beta-glucosidase activity [GO:0102483]; beta-glucoside catabolic process [GO:1901805]; galactosylceramide catabolic process [GO:0006683]; glucosylceramide catabolic process [GO:0006680]; glycoside catabolic process [GO:0016139]; glycosphingolipid metabolic process [GO:0006687]; glycosylceramide catabolic process [GO:0046477]; oligosaccharide catabolic process [GO:0009313]; positive regulation of exo-alpha-sialidase activity [GO:1903017]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12594539, ECO:0000269|PubMed:17595169}.
Q9H228	reviewed	S1PR5_HUMAN	Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8)	S1PR5 EDG8	Homo sapiens (Human)	398	FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. {ECO:0000250}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; regulation of metabolic process [GO:0019222]; regulation of neuron differentiation [GO:0045664]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; sphingosine-1-phosphate receptor activity [GO:0038036]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; sphingosine-1-phosphate receptor activity [GO:0038036]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; regulation of metabolic process [GO:0019222]; regulation of neuron differentiation [GO:0045664]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H237	reviewed	PORCN_HUMAN	Protein-serine O-palmitoleoyltransferase porcupine (EC 2.3.1.250) (Protein MG61)	PORCN MG61 PORC PPN	Homo sapiens (Human)	461	FUNCTION: Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. {ECO:0000250|UniProtKB:Q9JJJ7, ECO:0000269|PubMed:12034504, ECO:0000269|PubMed:20826466, ECO:0000269|PubMed:24292069}.		glycoprotein metabolic process [GO:0009100]; lipid modification [GO:0030258]; protein lipidation [GO:0006497]; protein palmitoleylation [GO:0045234]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; Wnt protein secretion [GO:0061355]; Wnt signaling pathway [GO:0016055]	AMPA glutamate receptor complex [GO:0032281]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]	palmitoleoyltransferase activity [GO:1990698]; Wnt-protein binding [GO:0017147]	AMPA glutamate receptor complex [GO:0032281]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; palmitoleoyltransferase activity [GO:1990698]; Wnt-protein binding [GO:0017147]; glycoprotein metabolic process [GO:0009100]; lipid modification [GO:0030258]; protein lipidation [GO:0006497]; protein palmitoleylation [GO:0045234]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; Wnt protein secretion [GO:0061355]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9JJJ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JJJ7}.
Q9H239	reviewed	MMP28_HUMAN	Matrix metalloproteinase-28 (MMP-28) (EC 3.4.24.-) (Epilysin)	MMP28 MMP25 UNQ1893/PRO4339	Homo sapiens (Human)	520	FUNCTION: Can degrade casein. Could play a role in tissues homeostasis and repair.		collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; negative regulation of macrophage chemotaxis [GO:0010760]; proteolysis [GO:0006508]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; negative regulation of macrophage chemotaxis [GO:0010760]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q9H244	reviewed	P2Y12_HUMAN	P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999)	P2RY12 HORK3	Homo sapiens (Human)	342	FUNCTION: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. {ECO:0000269|PubMed:11104774, ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:11502873, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}.		activation of phospholipase C activity [GO:0007202]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcium-mediated signaling [GO:0019722]; calcium-mediated signaling using extracellular calcium source [GO:0035585]; cell projection organization [GO:0030030]; cellular response to ATP [GO:0071318]; cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration [GO:0021808]; establishment of localization in cell [GO:0051649]; G protein-coupled receptor signaling pathway [GO:0007186]; hemostasis [GO:0007599]; lamellipodium assembly [GO:0030032]; monoatomic ion transport [GO:0006811]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of chemotaxis [GO:0050921]; positive regulation of integrin activation by cell surface receptor linked signal transduction [GO:0033626]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of monoatomic ion transport [GO:0043270]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of ruffle assembly [GO:1900029]; regulation of chemotaxis [GO:0050920]; regulation of microglial cell migration [GO:1904139]; response to axon injury [GO:0048678]; substrate-dependent cell migration, cell extension [GO:0006930]; visual system development [GO:0150063]	cell body membrane [GO:0044298]; cell projection membrane [GO:0031253]; cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled adenosine receptor activity [GO:0001609]; G protein-coupled ADP receptor activity [GO:0001621]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; guanyl-nucleotide exchange factor activity [GO:0005085]	cell body membrane [GO:0044298]; cell projection membrane [GO:0031253]; cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled adenosine receptor activity [GO:0001609]; G protein-coupled ADP receptor activity [GO:0001621]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; guanyl-nucleotide exchange factor activity [GO:0005085]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcium-mediated signaling [GO:0019722]; calcium-mediated signaling using extracellular calcium source [GO:0035585]; cell projection organization [GO:0030030]; cellular response to ATP [GO:0071318]; cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration [GO:0021808]; establishment of localization in cell [GO:0051649]; G protein-coupled receptor signaling pathway [GO:0007186]; hemostasis [GO:0007599]; lamellipodium assembly [GO:0030032]; monoatomic ion transport [GO:0006811]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of chemotaxis [GO:0050921]; positive regulation of integrin activation by cell surface receptor linked signal transduction [GO:0033626]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of monoatomic ion transport [GO:0043270]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of ruffle assembly [GO:1900029]; regulation of chemotaxis [GO:0050920]; regulation of microglial cell migration [GO:1904139]; response to axon injury [GO:0048678]; substrate-dependent cell migration, cell extension [GO:0006930]; visual system development [GO:0150063]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}; Multi-pass membrane protein {ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}.
Q9H251	reviewed	CAD23_HUMAN	Cadherin-23 (Otocadherin)	CDH23 KIAA1774 KIAA1812 UNQ1894/PRO4340	Homo sapiens (Human)	3354	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. {ECO:0000269|PubMed:11138009, ECO:0000269|PubMed:16679490}.		auditory receptor cell stereocilium organization [GO:0060088]; calcium ion transport [GO:0006816]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; photoreceptor cell maintenance [GO:0045494]; post-embryonic animal organ morphogenesis [GO:0048563]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	catenin complex [GO:0016342]; centrosome [GO:0005813]; cochlear hair cell ribbon synapse [GO:0098683]; kinocilium [GO:0060091]; membrane [GO:0016020]; photoreceptor inner segment [GO:0001917]; photoreceptor ribbon synapse [GO:0098684]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	catenin complex [GO:0016342]; centrosome [GO:0005813]; cochlear hair cell ribbon synapse [GO:0098683]; kinocilium [GO:0060091]; membrane [GO:0016020]; photoreceptor inner segment [GO:0001917]; photoreceptor ribbon synapse [GO:0098684]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; auditory receptor cell stereocilium organization [GO:0060088]; calcium ion transport [GO:0006816]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; photoreceptor cell maintenance [GO:0045494]; post-embryonic animal organ morphogenesis [GO:0048563]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
Q9H252	reviewed	KCNH6_HUMAN	Potassium voltage-gated channel subfamily H member 6 (Ether-a-go-go-related gene potassium channel 2) (ERG-2) (Eag-related protein 2) (Ether-a-go-go-related protein 2) (hERG-2) (hERG2) (Voltage-gated potassium channel subunit Kv11.2)	KCNH6 ERG2	Homo sapiens (Human)	994	FUNCTION: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly. {ECO:0000250}.		membrane repolarization during action potential [GO:0086011]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]	plasma membrane [GO:0005886]	inward rectifier potassium channel activity [GO:0005242]	plasma membrane [GO:0005886]; inward rectifier potassium channel activity [GO:0005242]; membrane repolarization during action potential [GO:0086011]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9H254	reviewed	SPTN4_HUMAN	Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)	SPTBN4 KIAA1642 SPTBN3	Homo sapiens (Human)	2564			actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; adult walking behavior [GO:0007628]; axonogenesis [GO:0007409]; cardiac conduction [GO:0061337]; central nervous system projection neuron axonogenesis [GO:0021952]; clustering of voltage-gated sodium channels [GO:0045162]; fertilization [GO:0009566]; negative regulation of heart rate [GO:0010459]; neuromuscular junction development [GO:0007528]; neuromuscular process [GO:0050905]; positive regulation of multicellular organism growth [GO:0040018]; protein localization to plasma membrane [GO:0072659]; protein-containing complex assembly [GO:0065003]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of sodium ion transport [GO:0002028]; sensory perception of sound [GO:0007605]; transmission of nerve impulse [GO:0019226]; vesicle-mediated transport [GO:0016192]	actin filament [GO:0005884]; axon hillock [GO:0043203]; axon initial segment [GO:0043194]; cell body fiber [GO:0070852]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; nuclear matrix [GO:0016363]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; PML body [GO:0016605]; spectrin [GO:0008091]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cytoskeletal protein-membrane anchor activity [GO:0106006]; phosphatase binding [GO:0019902]; phospholipid binding [GO:0005543]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]	actin filament [GO:0005884]; axon hillock [GO:0043203]; axon initial segment [GO:0043194]; cell body fiber [GO:0070852]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; nuclear matrix [GO:0016363]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; PML body [GO:0016605]; spectrin [GO:0008091]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cytoskeletal protein-membrane anchor activity [GO:0106006]; phosphatase binding [GO:0019902]; phospholipid binding [GO:0005543]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; adult walking behavior [GO:0007628]; axonogenesis [GO:0007409]; cardiac conduction [GO:0061337]; central nervous system projection neuron axonogenesis [GO:0021952]; clustering of voltage-gated sodium channels [GO:0045162]; fertilization [GO:0009566]; negative regulation of heart rate [GO:0010459]; neuromuscular junction development [GO:0007528]; neuromuscular process [GO:0050905]; positive regulation of multicellular organism growth [GO:0040018]; protein localization to plasma membrane [GO:0072659]; protein-containing complex assembly [GO:0065003]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of sodium ion transport [GO:0002028]; sensory perception of sound [GO:0007605]; transmission of nerve impulse [GO:0019226]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}.
Q9H255	reviewed	O51E2_HUMAN	Olfactory receptor 51E2 (HPRAJ) (Olfactory receptor OR11-16) (Prostate-specific G-protein coupled receptor)	OR51E2 PSGR	Homo sapiens (Human)	320	FUNCTION: Olfactory receptor (PubMed:29249973, PubMed:27226631). Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:29249973, PubMed:27226631, PubMed:19389702). The activity of this receptor is probably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631). Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973). Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). Activated by L-lactate in glomus cells (By similarity). {ECO:0000250|UniProtKB:Q8VBV9, ECO:0000269|PubMed:19389702, ECO:0000269|PubMed:23401498, ECO:0000269|PubMed:27226631, ECO:0000269|PubMed:29249973}.		cell migration [GO:0016477]; cellular response to fatty acid [GO:0071398]; melanocyte differentiation [GO:0030318]; melanocyte proliferation [GO:0097325]; positive regulation of blood pressure [GO:0045777]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of renin secretion into blood stream [GO:1900135]; steroid hormone mediated signaling pathway [GO:0043401]	early endosome membrane [GO:0031901]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; nuclear steroid receptor activity [GO:0003707]; olfactory receptor activity [GO:0004984]; signaling receptor activity [GO:0038023]	early endosome membrane [GO:0031901]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; nuclear steroid receptor activity [GO:0003707]; olfactory receptor activity [GO:0004984]; signaling receptor activity [GO:0038023]; cell migration [GO:0016477]; cellular response to fatty acid [GO:0071398]; melanocyte differentiation [GO:0030318]; melanocyte proliferation [GO:0097325]; positive regulation of blood pressure [GO:0045777]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of renin secretion into blood stream [GO:1900135]; steroid hormone mediated signaling pathway [GO:0043401]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23401498, ECO:0000269|PubMed:27226631, ECO:0000269|PubMed:29249973}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:27226631}; Multi-pass membrane protein {ECO:0000255}.
Q9H257	reviewed	CARD9_HUMAN	Caspase recruitment domain-containing protein 9 (hCARD9)	CARD9	Homo sapiens (Human)	536	FUNCTION: Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C-type lectin receptors (PubMed:26961233, PubMed:33558980). CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota (PubMed:24231284, PubMed:25702837, PubMed:25057046, PubMed:26679537, PubMed:26961233, PubMed:26521038, PubMed:27777981, PubMed:29080677, PubMed:33558980). Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (By similarity). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11053425, PubMed:26488816, PubMed:31296852, PubMed:26961233, PubMed:33558980). CARD9 signaling in antigen-presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells (PubMed:24231284). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (By similarity). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota (PubMed:33548172). Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection (PubMed:33548172). Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (By similarity). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:A2AIV8, ECO:0000269|PubMed:11053425, ECO:0000269|PubMed:24231284, ECO:0000269|PubMed:25057046, ECO:0000269|PubMed:25702837, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:26521038, ECO:0000269|PubMed:26679537, ECO:0000269|PubMed:26961233, ECO:0000269|PubMed:27777981, ECO:0000269|PubMed:29080677, ECO:0000269|PubMed:31296852, ECO:0000269|PubMed:33548172, ECO:0000269|PubMed:33558980}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	antifungal innate immune response [GO:0061760]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; immunoglobulin mediated immune response [GO:0016064]; JNK cascade [GO:0007254]; neutrophil mediated immunity [GO:0002446]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tumor necrosis factor production [GO:0032760]; protein homooligomerization [GO:0051260]; regulation of apoptotic process [GO:0042981]; regulation of interleukin-2 production [GO:0032663]; response to aldosterone [GO:1904044]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494]; response to xenobiotic stimulus [GO:0009410]	CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	CARD domain binding [GO:0050700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]	CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; CARD domain binding [GO:0050700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]; antifungal innate immune response [GO:0061760]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; immunoglobulin mediated immune response [GO:0016064]; JNK cascade [GO:0007254]; neutrophil mediated immunity [GO:0002446]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tumor necrosis factor production [GO:0032760]; protein homooligomerization [GO:0051260]; regulation of apoptotic process [GO:0042981]; regulation of interleukin-2 production [GO:0032663]; response to aldosterone [GO:1904044]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11053425, ECO:0000269|PubMed:26488816}.
Q9H267	reviewed	VP33B_HUMAN	Vacuolar protein sorting-associated protein 33B (hVPS33B)	VPS33B	Homo sapiens (Human)	617	FUNCTION: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Required for proper trafficking and targeting of the collagen-modifying enzyme lysyl hydroxylase 3 (LH3) to intracellular collagen (PubMed:28017832). Mediates phagolysosomal fusion in macrophages (PubMed:18474358). Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity). {ECO:0000250|UniProtKB:P59016, ECO:0000269|PubMed:18474358, ECO:0000269|PubMed:28017832, ECO:0000305|PubMed:20190753, ECO:0000305|PubMed:23918659}.		collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; lysosome localization [GO:0032418]; megakaryocyte development [GO:0035855]; melanosome localization [GO:0032400]; membrane fusion [GO:0061025]; peptidyl-lysine hydroxylation [GO:0017185]; phagosome-lysosome fusion [GO:0090385]; platelet alpha granule organization [GO:0070889]; protein transport [GO:0015031]; regulation of platelet aggregation [GO:0090330]; skin morphogenesis [GO:0043589]; vesicle-mediated transport [GO:0016192]	clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule [GO:0031091]; recycling endosome [GO:0055037]; vesicle tethering complex [GO:0099023]	protein-containing complex binding [GO:0044877]	clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule [GO:0031091]; recycling endosome [GO:0055037]; vesicle tethering complex [GO:0099023]; protein-containing complex binding [GO:0044877]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; lysosome localization [GO:0032418]; megakaryocyte development [GO:0035855]; melanosome localization [GO:0032400]; membrane fusion [GO:0061025]; peptidyl-lysine hydroxylation [GO:0017185]; phagosome-lysosome fusion [GO:0090385]; platelet alpha granule organization [GO:0070889]; protein transport [GO:0015031]; regulation of platelet aggregation [GO:0090330]; skin morphogenesis [GO:0043589]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:15052268}; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane {ECO:0000269|PubMed:15052268}; Peripheral membrane protein; Cytoplasmic side. Early endosome {ECO:0000269|PubMed:21411634}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:21411634}. Recycling endosome {ECO:0000269|PubMed:22753090}. Note=Colocalizes in clusters with VIPAS39 at cytoplasmic organelles (PubMed:19109425, PubMed:31479177). Colocalizes with RAB11A and VIPAS39 on recycling endosomes (PubMed:22753090). Colocalizes with AP-3, clathrin, Rab5 and Rab7b (PubMed:21411634). Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes (PubMed:18474358). {ECO:0000269|PubMed:18474358, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:21411634, ECO:0000269|PubMed:22753090}.
Q9H269	reviewed	VPS16_HUMAN	Vacuolar protein sorting-associated protein 16 homolog (hVPS16)	VPS16	Homo sapiens (Human)	839	FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770). {ECO:0000269|PubMed:23901104, ECO:0000269|PubMed:24554770, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25266290, ECO:0000305|PubMed:25783203}.		autophagosome maturation [GO:0097352]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; regulation of SNARE complex assembly [GO:0035542]; vacuole fusion, non-autophagic [GO:0042144]	autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; recycling endosome [GO:0055037]	actin binding [GO:0003779]	autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; recycling endosome [GO:0055037]; actin binding [GO:0003779]; autophagosome maturation [GO:0097352]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; regulation of SNARE complex assembly [GO:0035542]; vacuole fusion, non-autophagic [GO:0042144]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:17897319}; Peripheral membrane protein {ECO:0000269|PubMed:17897319}; Cytoplasmic side {ECO:0000269|PubMed:17897319}. Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:21802320}; Peripheral membrane protein {ECO:0000269|PubMed:17897319}; Cytoplasmic side {ECO:0000269|PubMed:17897319}. Early endosome {ECO:0000269|PubMed:18552835}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q920Q4}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24554770}. Note=Colocalizes with AP-3, clathrin, Rab5 and Rab7b (By similarity). Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes. {ECO:0000250|UniProtKB:Q920Q4, ECO:0000305}.
Q9H270	reviewed	VPS11_HUMAN	Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108)	VPS11 RNF108 PP3476	Homo sapiens (Human)	941	FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995). {ECO:0000269|PubMed:21148287, ECO:0000269|PubMed:23593995, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:24554770, ECO:0000305|PubMed:25266290, ECO:0000305|PubMed:25783203}.		autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; organelle fusion [GO:0048284]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein ubiquitination [GO:0016567]; regulation of organelle assembly [GO:1902115]; regulation of protein stability [GO:0031647]; regulation of SNARE complex assembly [GO:0035542]; vacuole organization [GO:0007033]; vesicle docking involved in exocytosis [GO:0006904]	autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]	metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; syntaxin binding [GO:0019905]; ubiquitin protein ligase activity [GO:0061630]	autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; syntaxin binding [GO:0019905]; ubiquitin protein ligase activity [GO:0061630]; autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; organelle fusion [GO:0048284]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein ubiquitination [GO:0016567]; regulation of organelle assembly [GO:1902115]; regulation of protein stability [GO:0031647]; regulation of SNARE complex assembly [GO:0035542]; vacuole organization [GO:0007033]; vesicle docking involved in exocytosis [GO:0006904]	SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:20682791}. Late endosome membrane {ECO:0000269|PubMed:11382755, ECO:0000269|PubMed:21148287}; Peripheral membrane protein {ECO:0000269|PubMed:11382755}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:11382755, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:21802320}; Peripheral membrane protein {ECO:0000269|PubMed:11382755}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:21148287, ECO:0000305}. Cytoplasmic vesicle {ECO:0000305}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000305}.
Q9H293	reviewed	IL25_HUMAN	Interleukin-25 (IL-25) (Interleukin-17E) (IL-17E)	IL25 IL17E UNQ3120/PRO10272	Homo sapiens (Human)	177	FUNCTION: Cytokine produced by various cells such as eosinophils, T-helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production (PubMed:25821217, PubMed:15860795). Promotes and augments T-helper type 2 responses locally or systemically (PubMed:25821217). Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction (By similarity). In turn, stimulates the JAK2-STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13 (PubMed:25821217). Induces also the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways (PubMed:15860795). Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13 (PubMed:11754819). {ECO:0000250|UniProtKB:Q8VHH8, ECO:0000269|PubMed:11754819, ECO:0000269|PubMed:15860795, ECO:0000269|PubMed:25821217}.		eosinophil differentiation [GO:0030222]; inflammatory response to antigenic stimulus [GO:0002437]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to fungus [GO:0009620]; response to nematode [GO:0009624]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; interleukin-17E receptor binding [GO:0030380]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; interleukin-17E receptor binding [GO:0030380]; eosinophil differentiation [GO:0030222]; inflammatory response to antigenic stimulus [GO:0002437]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to fungus [GO:0009620]; response to nematode [GO:0009624]	SUBCELLULAR LOCATION: Secreted.
Q9H295	reviewed	DCSTP_HUMAN	Dendritic cell-specific transmembrane protein (DC-STAMP) (hDC-STAMP) (Dendrocyte-expressed seven transmembrane protein) (IL-four-induced protein) (FIND) (Transmembrane 7 superfamily member 4)	DCSTAMP TM7SF4	Homo sapiens (Human)	470	FUNCTION: Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.		cellular response to interleukin-4 [GO:0071353]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; membrane fusion [GO:0061025]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of cell growth [GO:0030308]; osteoclast differentiation [GO:0030316]; osteoclast fusion [GO:0072675]; positive regulation of bone resorption [GO:0045780]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of monocyte differentiation [GO:0045657]	cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]		cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cellular response to interleukin-4 [GO:0071353]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; membrane fusion [GO:0061025]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of cell growth [GO:0030308]; osteoclast differentiation [GO:0030316]; osteoclast fusion [GO:0072675]; positive regulation of bone resorption [GO:0045780]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of monocyte differentiation [GO:0045657]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Note=Localizes to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity). {ECO:0000250}.
Q9H299	reviewed	SH3L3_HUMAN	SH3 domain-binding glutamic acid-rich-like protein 3 (SH3 domain-binding protein 1) (SH3BP-1) (TNF inhibitory protein B1) (TIP-B1)	SH3BGRL3 P1725	Homo sapiens (Human)	93	FUNCTION: Could act as a modulator of glutaredoxin biological activity (Probable). May play a role in cytoskeleton organization (PubMed:34380438). {ECO:0000269|PubMed:34380438, ECO:0000305|PubMed:15907482}.		cytoskeleton organization [GO:0007010]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; ruffle membrane [GO:0032587]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; ruffle membrane [GO:0032587]; cytoskeleton organization [GO:0007010]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10554026, ECO:0000269|PubMed:11137621, ECO:0000269|PubMed:11344125, ECO:0000269|PubMed:15907482}. Cell projection, ruffle membrane {ECO:0000269|PubMed:34380438, ECO:0000305|PubMed:11344125}. Nucleus {ECO:0000269|PubMed:11444877}.
Q9H2A2	reviewed	AL8A1_HUMAN	2-aminomuconic semialdehyde dehydrogenase (EC 1.2.1.32) (Aldehyde dehydrogenase 12) (Aldehyde dehydrogenase family 8 member A1)	ALDH8A1 ALDH12	Homo sapiens (Human)	487	FUNCTION: Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. {ECO:0000269|PubMed:29703752}.	MISCELLANEOUS: [Isoform 2]: Lacks enzymatic activity. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	9-cis-retinoic acid biosynthetic process [GO:0042904]; L-kynurenine catabolic process [GO:0097053]; retinal metabolic process [GO:0042574]; retinoic acid metabolic process [GO:0042573]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	aminomuconate-semialdehyde dehydrogenase activity [GO:0047102]; retinal dehydrogenase activity [GO:0001758]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; aminomuconate-semialdehyde dehydrogenase activity [GO:0047102]; retinal dehydrogenase activity [GO:0001758]; 9-cis-retinoic acid biosynthetic process [GO:0042904]; L-kynurenine catabolic process [GO:0097053]; retinal metabolic process [GO:0042574]; retinoic acid metabolic process [GO:0042573]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9H2A7	reviewed	CXL16_HUMAN	C-X-C motif chemokine 16 (Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein) (SR-PSOX) (Small-inducible cytokine B16) (Transmembrane chemokine CXCL16)	CXCL16 SCYB16 SRPSOX UNQ2759/PRO6714	Homo sapiens (Human)	254	FUNCTION: Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. {ECO:0000250}.		chemotaxis [GO:0006935]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; receptor-mediated endocytosis [GO:0006898]; response to cytokine [GO:0034097]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; T cell chemotaxis [GO:0010818]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]	chemokine activity [GO:0008009]; low-density lipoprotein particle receptor activity [GO:0005041]; scavenger receptor activity [GO:0005044]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; chemokine activity [GO:0008009]; low-density lipoprotein particle receptor activity [GO:0005041]; scavenger receptor activity [GO:0005044]; chemotaxis [GO:0006935]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; receptor-mediated endocytosis [GO:0006898]; response to cytokine [GO:0034097]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; T cell chemotaxis [GO:0010818]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted. Note=Also exists as a soluble form.
Q9H2A9	reviewed	CHST8_HUMAN	Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-acetylgalactosamine-4-O-sulfotransferase 1)	CHST8	Homo sapiens (Human)	424	FUNCTION: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin. {ECO:0000269|PubMed:10988300, ECO:0000269|PubMed:11445554}.		carbohydrate biosynthetic process [GO:0016051]; central nervous system development [GO:0007417]; hormone biosynthetic process [GO:0042446]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; sulfotransferase activity [GO:0008146]; carbohydrate biosynthetic process [GO:0016051]; central nervous system development [GO:0007417]; hormone biosynthetic process [GO:0042446]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9H2B2	reviewed	SYT4_HUMAN	Synaptotagmin-4 (Synaptotagmin IV) (SytIV)	SYT4 KIAA1342	Homo sapiens (Human)	425	FUNCTION: Synaptotagmin family member which does not bind Ca(2+) (PubMed:23999003) (By similarity). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P50232, ECO:0000269|PubMed:23999003}.		calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; dense core granule cytoskeletal transport [GO:0099519]; memory [GO:0007613]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of catecholamine secretion [GO:0033604]; negative regulation of protein secretion [GO:0050709]; negative regulation of retrograde trans-synaptic signaling by neuropeptide [GO:1905433]; negative regulation of short-term neuronal synaptic plasticity [GO:0048174]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dense core granule exocytosis [GO:1905415]; positive regulation of glutamate secretion [GO:0014049]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; regulation of endocytosis [GO:0030100]; regulation of postsynaptic dense core vesicle exocytosis [GO:0150044]; regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0150035]; regulation of vesicle fusion [GO:0031338]; vesicle fusion [GO:0006906]	astrocyte projection [GO:0097449]; axon [GO:0030424]; dendrite [GO:0030425]; dense core granule membrane [GO:0032127]; exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; microvesicle [GO:1990742]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; neuronal dense core vesicle membrane [GO:0099012]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]	astrocyte projection [GO:0097449]; axon [GO:0030424]; dendrite [GO:0030425]; dense core granule membrane [GO:0032127]; exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; microvesicle [GO:1990742]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; neuronal dense core vesicle membrane [GO:0099012]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; dense core granule cytoskeletal transport [GO:0099519]; memory [GO:0007613]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of catecholamine secretion [GO:0033604]; negative regulation of protein secretion [GO:0050709]; negative regulation of retrograde trans-synaptic signaling by neuropeptide [GO:1905433]; negative regulation of short-term neuronal synaptic plasticity [GO:0048174]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dense core granule exocytosis [GO:1905415]; positive regulation of glutamate secretion [GO:0014049]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; regulation of endocytosis [GO:0030100]; regulation of postsynaptic dense core vesicle exocytosis [GO:0150044]; regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0150035]; regulation of vesicle fusion [GO:0031338]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250|UniProtKB:P50232}; Single-pass membrane protein {ECO:0000250|UniProtKB:P50232}.
Q9H2B4	reviewed	S26A1_HUMAN	Sulfate anion transporter 1 (SAT-1) (Solute carrier family 26 member 1)	SLC26A1 SAT1	Homo sapiens (Human)	701	FUNCTION: Sodium-independent sulfate anion transporter (PubMed:12713736, PubMed:27125215). Can transport other anions including bicarbonate, thiosulfate and oxalate by mediating sulfate-thiosulfate, sulfate-hydrogencarbonate and sulfate-oxalate anion exchange (PubMed:12713736, PubMed:27125215). Mediates oxalate-hydrogencarbonate anion exchange (By similarity). {ECO:0000250|UniProtKB:P58735, ECO:0000269|PubMed:12713736, ECO:0000269|PubMed:27125215}.		chloride transport [GO:0006821]; oxalate transport [GO:0019532]; sulfate transport [GO:0008272]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:bicarbonate antiporter activity [GO:0015383]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:bicarbonate antiporter activity [GO:0015383]; chloride transport [GO:0006821]; oxalate transport [GO:0019532]; sulfate transport [GO:0008272]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P58735}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P45380}; Multi-pass membrane protein {ECO:0000255}.
Q9H2C0	reviewed	GAN_HUMAN	Gigaxonin (Kelch-like protein 16)	GAN GAN1 KLHL16	Homo sapiens (Human)	597	FUNCTION: Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. {ECO:0000269|PubMed:12147674, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16227972, ECO:0000269|PubMed:16303566}.		cytoskeleton organization [GO:0007010]; protein ubiquitination [GO:0016567]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]		Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; cytoskeleton organization [GO:0007010]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton.
Q9H2C1	reviewed	LHX5_HUMAN	LIM/homeobox protein Lhx5 (LIM homeobox protein 5)	LHX5	Homo sapiens (Human)	402	FUNCTION: Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.		cell proliferation in forebrain [GO:0021846]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [GO:0021937]; forebrain neuron differentiation [GO:0021879]; hippocampus development [GO:0021766]; neuroblast proliferation [GO:0007405]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of neuroblast proliferation [GO:1902692]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord association neuron differentiation [GO:0021527]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; cell proliferation in forebrain [GO:0021846]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [GO:0021937]; forebrain neuron differentiation [GO:0021879]; hippocampus development [GO:0021766]; neuroblast proliferation [GO:0007405]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of neuroblast proliferation [GO:1902692]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord association neuron differentiation [GO:0021527]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H2C2	reviewed	ARV1_HUMAN	Protein ARV1 (hARV1)	ARV1 HT035	Homo sapiens (Human)	271	FUNCTION: Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:11063737, PubMed:12145310, PubMed:20663892). Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892). {ECO:0000269|PubMed:11063737, ECO:0000269|PubMed:12145310, ECO:0000269|PubMed:20663892}.	MISCELLANEOUS: When transfected in S.cerevisiae, it can complement the absence of yeast of ARV1 protein, suggesting a conserved role in sphingolipid metabolism. {ECO:0000269|PubMed:11063737, ECO:0000269|PubMed:12145310}.	bile acid metabolic process [GO:0008206]; cholesterol biosynthetic process [GO:0006695]; cholesterol transport [GO:0030301]; intracellular sterol transport [GO:0032366]; regulation of cholesterol metabolic process [GO:0090181]; regulation of intracellular cholesterol transport [GO:0032383]; regulation of plasma membrane sterol distribution [GO:0097036]; sphingolipid metabolic process [GO:0006665]; sterol metabolic process [GO:0016125]	cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	sterol transporter activity [GO:0015248]	cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; sterol transporter activity [GO:0015248]; bile acid metabolic process [GO:0008206]; cholesterol biosynthetic process [GO:0006695]; cholesterol transport [GO:0030301]; intracellular sterol transport [GO:0032366]; regulation of cholesterol metabolic process [GO:0090181]; regulation of intracellular cholesterol transport [GO:0032383]; regulation of plasma membrane sterol distribution [GO:0097036]; sphingolipid metabolic process [GO:0006665]; sterol metabolic process [GO:0016125]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20663892}; Multi-pass membrane protein {ECO:0000305}.
Q9H2D1	reviewed	S2532_HUMAN	Solute carrier family 25 member 32 (Mitochondrial FAD transporter)	SLC25A32 MFT MFTC	Homo sapiens (Human)	315	FUNCTION: Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis. {ECO:0000269|PubMed:16165386, ECO:0000269|PubMed:29666258, ECO:0000269|PubMed:35727412}.		folate import into mitochondrion [GO:1904947]; folic acid metabolic process [GO:0046655]; folic acid transport [GO:0015884]; mitochondrial FAD transmembrane transport [GO:1990548]; mitochondrial transport [GO:0006839]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	FAD transmembrane transporter activity [GO:0015230]; folic acid transmembrane transporter activity [GO:0008517]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; FAD transmembrane transporter activity [GO:0015230]; folic acid transmembrane transporter activity [GO:0008517]; folate import into mitochondrion [GO:1904947]; folic acid metabolic process [GO:0046655]; folic acid transport [GO:0015884]; mitochondrial FAD transmembrane transport [GO:1990548]; mitochondrial transport [GO:0006839]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:29666258}; Multi-pass membrane protein {ECO:0000255}.
Q9H2D6	reviewed	TARA_HUMAN	TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin)	TRIOBP KIAA1662 TARA HRIHFB2122	Homo sapiens (Human)	2365	FUNCTION: [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:24692559, PubMed:22820163). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.	MISCELLANEOUS: [Isoform 1]: Insoluble aggregates is found in the brain of schizophrenia patients. {ECO:0000269|PubMed:25333879}.; MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing of isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Produced by alternative splicing of isoform 1. {ECO:0000305}.	actin modification [GO:0030047]; auditory receptor cell stereocilium organization [GO:0060088]; barbed-end actin filament capping [GO:0051016]; cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; sensory perception of sound [GO:0007605]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; stereocilium base [GO:0120044]	actin filament binding [GO:0051015]; myosin II binding [GO:0045159]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; stereocilium base [GO:0120044]; actin filament binding [GO:0051015]; myosin II binding [GO:0045159]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625]; actin modification [GO:0030047]; auditory receptor cell stereocilium organization [GO:0060088]; barbed-end actin filament capping [GO:0051016]; cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9853615}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:22820163}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559}. Midbody {ECO:0000269|PubMed:22820163}. Chromosome, telomere {ECO:0000269|PubMed:24692559}. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody. {ECO:0000269|PubMed:22820163}.
Q9H2E6	reviewed	SEM6A_HUMAN	Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1)	SEMA6A KIAA1368 SEMAQ	Homo sapiens (Human)	1030	FUNCTION: Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. {ECO:0000250|UniProtKB:O35464}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}.		animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell surface receptor signaling pathway [GO:0007166]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cytoskeleton organization [GO:0007010]; negative chemotaxis [GO:0050919]; negative regulation of angiogenesis [GO:0016525]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion involved in sprouting angiogenesis [GO:0106089]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive regulation of neuron migration [GO:2001224]; semaphorin-plexin signaling pathway [GO:0071526]	axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell surface receptor signaling pathway [GO:0007166]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cytoskeleton organization [GO:0007010]; negative chemotaxis [GO:0050919]; negative regulation of angiogenesis [GO:0016525]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion involved in sprouting angiogenesis [GO:0106089]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive regulation of neuron migration [GO:2001224]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32302524}; Single-pass type I membrane protein {ECO:0000255}.
Q9H2F3	reviewed	3BHS7_HUMAN	3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3-beta-HSD VII) (3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase) (C(27) 3-beta-HSD) (EC 1.1.1.-) (Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase) (EC 1.1.1.181)	HSD3B7	Homo sapiens (Human)	369	FUNCTION: The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. {ECO:0000250|UniProtKB:Q9EQC1, ECO:0000269|PubMed:11067870}.		B cell chemotaxis [GO:0035754]; bile acid biosynthetic process [GO:0006699]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]	3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity [GO:0047016]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; 3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity [GO:0047016]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; B cell chemotaxis [GO:0035754]; bile acid biosynthetic process [GO:0006699]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Q9H2F5	reviewed	EPC1_HUMAN	Enhancer of polycomb homolog 1	EPC1	Homo sapiens (Human)	836	FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463). {ECO:0000250|UniProtKB:Q8C9X6, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}.		DNA-templated transcription [GO:0006351]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]	cytoplasm [GO:0005737]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Piccolo NuA4 histone acetyltransferase complex [GO:0032777]; site of double-strand break [GO:0035861]	chromatin-protein adaptor activity [GO:0140463]; enzyme-substrate adaptor activity [GO:0140767]	cytoplasm [GO:0005737]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Piccolo NuA4 histone acetyltransferase complex [GO:0032777]; site of double-strand break [GO:0035861]; chromatin-protein adaptor activity [GO:0140463]; enzyme-substrate adaptor activity [GO:0140767]; DNA-templated transcription [GO:0006351]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10976108}. Cytoplasm {ECO:0000250|UniProtKB:Q8C9X6}.
Q9H2F9	reviewed	CCD68_HUMAN	Coiled-coil domain-containing protein 68 (Cutaneous T-cell lymphoma-associated antigen se57-1) (CTCL-associated antigen se57-1)	CCDC68	Homo sapiens (Human)	335	FUNCTION: Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:28422092}.		intracellular signal transduction [GO:0035556]; microtubule anchoring at centrosome [GO:0034454]; protein localization [GO:0008104]	centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; cytoplasm [GO:0005737]		centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; cytoplasm [GO:0005737]; intracellular signal transduction [GO:0035556]; microtubule anchoring at centrosome [GO:0034454]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28422092}. Note=Localizes to the subdistal appendages of centrioles (PubMed:28422092). {ECO:0000269|PubMed:28422092}.
Q9H2G2	reviewed	SLK_HUMAN	STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)	SLK KIAA0204 STK2	Homo sapiens (Human)	1235	FUNCTION: Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}.		apoptotic process [GO:0006915]; cytoplasmic microtubule organization [GO:0031122]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cytoplasmic microtubule organization [GO:0031122]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9H2G4	reviewed	TSYL2_HUMAN	Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79)	TSPYL2 CDA1 DENTT TSPX HRIHFB2216	Homo sapiens (Human)	693	FUNCTION: Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}.	MISCELLANEOUS: Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation. {ECO:0000250}.; MISCELLANEOUS: Subject to X inactivation.	cell cycle [GO:0007049]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA replication [GO:0008156]; nucleosome assembly [GO:0006334]; regulation of protein kinase activity [GO:0045859]; regulation of signal transduction [GO:0009966]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; rDNA binding [GO:0000182]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; rDNA binding [GO:0000182]; cell cycle [GO:0007049]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA replication [GO:0008156]; nucleosome assembly [GO:0006334]; regulation of protein kinase activity [GO:0045859]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11318608, ECO:0000269|PubMed:11395479}. Cytoplasm {ECO:0000250}. Note=Enriched in transcriptionally active regions of chromatin in neurons. {ECO:0000250}.
Q9H2G9	reviewed	GO45_HUMAN	Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor)	BLZF1 JEM1	Homo sapiens (Human)	400	FUNCTION: Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. {ECO:0000269|PubMed:11739401}.		Golgi organization [GO:0007030]; Golgi to plasma membrane protein transport [GO:0043001]	cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	enzyme binding [GO:0019899]; ubiquitin protein ligase binding [GO:0031625]	cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; ubiquitin protein ligase binding [GO:0031625]; Golgi organization [GO:0007030]; Golgi to plasma membrane protein transport [GO:0043001]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11739401}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:11056056, ECO:0000269|PubMed:9129147}. Note=Detected in the nucleus upon heterologous expression. Not detected in the cytoplasm. {ECO:0000269|PubMed:11056056, ECO:0000269|PubMed:9129147}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11056056}. Note=Not detected in the nucleus. {ECO:0000269|PubMed:11056056}.
Q9H2H0	reviewed	CXXC4_HUMAN	CXXC-type zinc finger protein 4 (Inhibition of the Dvl and axin complex protein)	CXXC4 IDAX	Homo sapiens (Human)	198	FUNCTION: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q6NXI8, ECO:0000269|PubMed:29276034}.		negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055]; zygotic specification of dorsal/ventral axis [GO:0007352]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]	methyl-CpG binding [GO:0008327]; PDZ domain binding [GO:0030165]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; methyl-CpG binding [GO:0008327]; PDZ domain binding [GO:0030165]; zinc ion binding [GO:0008270]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055]; zygotic specification of dorsal/ventral axis [GO:0007352]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9EQC9}.
Q9H2H8	reviewed	PPIL3_HUMAN	Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3)	PPIL3	Homo sapiens (Human)	161	FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.		mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]	peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]	
Q9H2H9	reviewed	S38A1_HUMAN	Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1)	SLC38A1 ATA1 NAT2 SAT1 SNAT1	Homo sapiens (Human)	487	FUNCTION: Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:20599747, PubMed:10891391). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9JM15, ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:20599747}.		amino acid import [GO:0043090]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; female pregnancy [GO:0007565]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; glutamine metabolic process [GO:0006541]; glutamine transport [GO:0006868]; L-alpha-amino acid transmembrane transport [GO:1902475]; neurotransmitter uptake [GO:0001504]; neutral amino acid transport [GO:0015804]; positive regulation of L-glutamine import across plasma membrane [GO:1901036]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, GABAergic [GO:0032228]; transport across blood-brain barrier [GO:0150104]	axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; glycine:sodium symporter activity [GO:0015375]; L-amino acid transmembrane transporter activity [GO:0015179]; L-glutamine transmembrane transporter activity [GO:0015186]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298]	axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; glycine:sodium symporter activity [GO:0015375]; L-amino acid transmembrane transporter activity [GO:0015179]; L-glutamine transmembrane transporter activity [GO:0015186]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298]; amino acid import [GO:0043090]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; female pregnancy [GO:0007565]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; glutamine metabolic process [GO:0006541]; glutamine transport [GO:0006868]; L-alpha-amino acid transmembrane transport [GO:1902475]; neurotransmitter uptake [GO:0001504]; neutral amino acid transport [GO:0015804]; positive regulation of L-glutamine import across plasma membrane [GO:1901036]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, GABAergic [GO:0032228]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15054072}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JM15}. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain. {ECO:0000250|UniProtKB:Q9JM15}.
Q9H2J4	reviewed	PDCL3_HUMAN	Phosducin-like protein 3 (HTPHLP) (PhPL3) (Viral IAP-associated factor 1) (VIAF-1)	PDCL3 PhLP2A VIAF1	Homo sapiens (Human)	239	FUNCTION: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430). {ECO:0000250|UniProtKB:Q4KLJ8, ECO:0000269|PubMed:15371430, ECO:0000269|PubMed:17429077, ECO:0000269|PubMed:23792958, ECO:0000269|PubMed:26059764}.		actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; chaperone-mediated protein folding [GO:0061077]; negative regulation of chaperone-mediated protein folding [GO:1903645]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; perinucleolar compartment [GO:0097356]; protein-containing complex [GO:0032991]	protein folding chaperone [GO:0044183]; vascular endothelial growth factor receptor 2 binding [GO:0043184]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; perinucleolar compartment [GO:0097356]; protein-containing complex [GO:0032991]; protein folding chaperone [GO:0044183]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; chaperone-mediated protein folding [GO:0061077]; negative regulation of chaperone-mediated protein folding [GO:1903645]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15371430, ECO:0000269|PubMed:26059764}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:26059764}. Endoplasmic reticulum {ECO:0000269|PubMed:26059764}.
Q9H2J7	reviewed	S6A15_HUMAN	Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3)	SLC6A15 B0AT2 NTT73 SBAT1	Homo sapiens (Human)	730	FUNCTION: Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}.		amino acid transport [GO:0006865]; leucine transport [GO:0015820]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; proline transport [GO:0015824]; sodium ion transmembrane transport [GO:0035725]	membrane [GO:0016020]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; branched-chain amino acid:sodium symporter activity [GO:0015657]; neurotransmitter transmembrane transporter activity [GO:0005326]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298]	membrane [GO:0016020]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; branched-chain amino acid:sodium symporter activity [GO:0015657]; neurotransmitter transmembrane transporter activity [GO:0005326]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298]; amino acid transport [GO:0006865]; leucine transport [GO:0015820]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; proline transport [GO:0015824]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:16226721}; Multi-pass membrane protein {ECO:0000305}.
Q9H2K0	reviewed	IF3M_HUMAN	Translation initiation factor IF-3, mitochondrial (IF-3(Mt)) (IF-3Mt) (IF3(mt)) (IF3mt)	MTIF3 DC38	Homo sapiens (Human)	278	FUNCTION: IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. {ECO:0000269|PubMed:12095986}.		mitochondrial translational initiation [GO:0070124]; ribosome disassembly [GO:0032790]	mitochondrion [GO:0005739]	ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	mitochondrion [GO:0005739]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; mitochondrial translational initiation [GO:0070124]; ribosome disassembly [GO:0032790]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q9H2K2	reviewed	TNKS2_HUMAN	Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein)	TNKS2 PARP5B TANK2 TNKL	Homo sapiens (Human)	1166	FUNCTION: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:11802774, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379}.		negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; Wnt signaling pathway [GO:0016055]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; perinuclear region of cytoplasm [GO:0048471]	enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; perinuclear region of cytoplasm [GO:0048471]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere {ECO:0000305}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
Q9H2K8	reviewed	TAOK3_HUMAN	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3)	TAOK3 DPK JIK KDS MAP3K18	Homo sapiens (Human)	898	FUNCTION: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). {ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of JNK cascade [GO:0046329]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of MAPK cascade [GO:0043408]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; protein kinase inhibitor activity [GO:0004860]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transferase activity [GO:0016740]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein kinase inhibitor activity [GO:0004860]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transferase activity [GO:0016740]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of JNK cascade [GO:0046329]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of MAPK cascade [GO:0043408]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:13679851}. Cell membrane {ECO:0000269|PubMed:13679851}; Peripheral membrane protein {ECO:0000269|PubMed:13679851}. Note=Also localized to the peripheral cell membrane.
Q9H2L4	reviewed	TMM60_HUMAN	Transmembrane protein 60	TMEM60 C7orf35 DC32	Homo sapiens (Human)	133				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9H2L5	reviewed	RASF4_HUMAN	Ras association domain-containing protein 4	RASSF4 AD037	Homo sapiens (Human)	321	FUNCTION: Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest. {ECO:0000269|PubMed:15574778}.		cell cycle [GO:0007049]; signal transduction [GO:0007165]			cell cycle [GO:0007049]; signal transduction [GO:0007165]	
Q9H2M3	reviewed	BHMT2_HUMAN	S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2)	BHMT2	Homo sapiens (Human)	363	FUNCTION: Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. {ECO:0000269|PubMed:18230605}.		L-methionine salvage [GO:0071267]; methylation [GO:0032259]; S-adenosylmethionine metabolic process [GO:0046500]; S-methylmethionine metabolic process [GO:0033477]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	S-methylmethionine-homocysteine S-methyltransferase activity [GO:0061627]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; S-methylmethionine-homocysteine S-methyltransferase activity [GO:0061627]; zinc ion binding [GO:0008270]; L-methionine salvage [GO:0071267]; methylation [GO:0032259]; S-adenosylmethionine metabolic process [GO:0046500]; S-methylmethionine metabolic process [GO:0033477]	
Q9H2M9	reviewed	RBGPR_HUMAN	Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit)	RAB3GAP2 KIAA0839	Homo sapiens (Human)	1393	FUNCTION: Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:9733780, PubMed:24891604). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:9733780}.		establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; intracellular protein transport [GO:0006886]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; positive regulation of protein lipidation [GO:1903061]; regulation of GTPase activity [GO:0043087]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	enzyme activator activity [GO:0008047]; enzyme regulator activity [GO:0030234]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; enzyme activator activity [GO:0008047]; enzyme regulator activity [GO:0030234]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; intracellular protein transport [GO:0006886]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; positive regulation of protein lipidation [GO:1903061]; regulation of GTPase activity [GO:0043087]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5U1Z0}. Endoplasmic reticulum {ECO:0000305|PubMed:24891604}. Note=In neurons, it is enriched in the synaptic soluble fraction. {ECO:0000250|UniProtKB:Q5U1Z0}.
Q9H2P0	reviewed	ADNP_HUMAN	Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein)	ADNP ADNP1 KIAA0784	Homo sapiens (Human)	1102	FUNCTION: May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}.	MISCELLANEOUS: When isolated from the sequence, neuroprotective peptide (NAP) provides neuroprotection against the amyloid-beta peptide.	cellular response to extracellular stimulus [GO:0031668]; cGMP-mediated signaling [GO:0019934]; estrous cycle [GO:0044849]; intracellular nitric oxide homeostasis [GO:0033484]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of synaptic transmission [GO:0050805]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; positive regulation of axon extension [GO:0045773]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of synapse assembly [GO:0051965]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to carbohydrate [GO:0009743]; response to inorganic substance [GO:0010035]; short-term memory [GO:0007614]	axon [GO:0030424]; chromatin [GO:0000785]; dendrite [GO:0030425]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	beta-catenin binding [GO:0008013]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; copper ion binding [GO:0005507]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; peptide binding [GO:0042277]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	axon [GO:0030424]; chromatin [GO:0000785]; dendrite [GO:0030425]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; beta-catenin binding [GO:0008013]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; copper ion binding [GO:0005507]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; peptide binding [GO:0042277]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cellular response to extracellular stimulus [GO:0031668]; cGMP-mediated signaling [GO:0019934]; estrous cycle [GO:0044849]; intracellular nitric oxide homeostasis [GO:0033484]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of synaptic transmission [GO:0050805]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; positive regulation of axon extension [GO:0045773]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of synapse assembly [GO:0051965]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to carbohydrate [GO:0009743]; response to inorganic substance [GO:0010035]; short-term memory [GO:0007614]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. Chromosome {ECO:0000250|UniProtKB:Q9Z103}.
Q9H2P9	reviewed	DPH5_HUMAN	Diphthine methyl ester synthase (EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)	DPH5 AD-018 CGI-30 HSPC143 NPD015	Homo sapiens (Human)	285	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. {ECO:0000250|UniProtKB:P32469, ECO:0000269|PubMed:23486472}.		methylation [GO:0032259]; protein histidyl modification to diphthamide [GO:0017183]	cytosol [GO:0005829]	diphthine synthase activity [GO:0004164]	cytosol [GO:0005829]; diphthine synthase activity [GO:0004164]; methylation [GO:0032259]; protein histidyl modification to diphthamide [GO:0017183]	
Q9H2R5	reviewed	KLK15_HUMAN	Kallikrein-15 (EC 3.4.21.-) (ACO protease)	KLK15	Homo sapiens (Human)	256	FUNCTION: Protease whose physiological substrate is not yet known.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	proteolysis [GO:0006508]	extracellular region [GO:0005576]; secretory granule [GO:0030141]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular region [GO:0005576]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H2S1	reviewed	KCNN2_HUMAN	Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)	KCNN2	Homo sapiens (Human)	579	FUNCTION: Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:10991935, PubMed:9287325, PubMed:33242881). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. {ECO:0000269|PubMed:10991935, ECO:0000269|PubMed:32212350, ECO:0000269|PubMed:9287325}.		membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of potassium ion transmembrane transport [GO:1901379]	cell surface [GO:0009986]; dendritic spine [GO:0043197]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; Z disc [GO:0030018]	alpha-actinin binding [GO:0051393]; calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; small conductance calcium-activated potassium channel activity [GO:0016286]	cell surface [GO:0009986]; dendritic spine [GO:0043197]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; Z disc [GO:0030018]; alpha-actinin binding [GO:0051393]; calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; small conductance calcium-activated potassium channel activity [GO:0016286]; membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of potassium ion transmembrane transport [GO:1901379]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9H2S5	reviewed	RNF39_HUMAN	RING finger protein 39 (Protein HZFw)	RNF39 HZFW	Homo sapiens (Human)	420	FUNCTION: May play a role in prolonged long term-potentiation (LTP) maintenance. {ECO:0000250}.		protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9H2S6	reviewed	TNMD_HUMAN	Tenomodulin (TeM) (hTeM) (Chondromodulin-1-like protein) (ChM1L) (hChM1L) (Chondromodulin-I-like protein) (Myodulin) (Tendin)	TNMD CHM1L UNQ771/PRO1565	Homo sapiens (Human)	317	FUNCTION: May be an angiogenesis inhibitor.		endothelial cell morphogenesis [GO:0001886]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]		cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; endothelial cell morphogenesis [GO:0001886]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Nucleus envelope.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Nucleus envelope.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Q9H2S9	reviewed	IKZF4_HUMAN	Zinc finger protein Eos (Ikaros family zinc finger protein 4)	IKZF4 KIAA1782 ZNFN1A4	Homo sapiens (Human)	585	FUNCTION: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). {ECO:0000250|UniProtKB:Q8C208, ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:12015313, ECO:0000269|PubMed:12444977}.	MISCELLANEOUS: 'Eos' means 'rising sun' in Greek.	negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity [GO:0003700]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity [GO:0003700]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12444977}.
Q9H2U1	reviewed	DHX36_HUMAN	ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein)	DHX36 DDX36 KIAA1488 MLEL1 RHAU	Homo sapiens (Human)	1008	FUNCTION: Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). {ECO:0000250|UniProtKB:D4A2Z8, ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:16150737, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18842585, ECO:0000269|PubMed:18854321, ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21586581, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:21993297, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24151078, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:25579584, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26489465, ECO:0000269|PubMed:27940037}.	MISCELLANEOUS: [Isoform 2]: More unstable than isoform 1. {ECO:0000269|PubMed:14731398}.	3'-UTR-mediated mRNA destabilization [GO:0061158]; cell differentiation [GO:0030154]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to UV [GO:0034644]; defense response to virus [GO:0051607]; G-quadruplex DNA unwinding [GO:0044806]; innate immune response [GO:0045087]; negative regulation of translation [GO:0017148]; ossification [GO:0001503]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of gene expression [GO:0010628]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of embryonic development [GO:0045995]; regulation of mRNA stability [GO:0043488]; regulation of transcription by RNA polymerase III [GO:0006359]; response to exogenous dsRNA [GO:0043330]; RNA secondary structure unwinding [GO:0010501]; spermatogenesis [GO:0007283]; telomerase RNA stabilization [GO:0090669]	axon [GO:0030424]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; histone deacetylase binding [GO:0042826]; magnesium ion binding [GO:0000287]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; pre-miRNA binding [GO:0070883]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; telomerase RNA binding [GO:0070034]; transcription cis-regulatory region binding [GO:0000976]	axon [GO:0030424]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; histone deacetylase binding [GO:0042826]; magnesium ion binding [GO:0000287]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; pre-miRNA binding [GO:0070883]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; telomerase RNA binding [GO:0070034]; transcription cis-regulatory region binding [GO:0000976]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; cell differentiation [GO:0030154]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to UV [GO:0034644]; defense response to virus [GO:0051607]; G-quadruplex DNA unwinding [GO:0044806]; innate immune response [GO:0045087]; negative regulation of translation [GO:0017148]; ossification [GO:0001503]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of gene expression [GO:0010628]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of embryonic development [GO:0045995]; regulation of mRNA stability [GO:0043488]; regulation of transcription by RNA polymerase III [GO:0006359]; response to exogenous dsRNA [GO:0043330]; RNA secondary structure unwinding [GO:0010501]; spermatogenesis [GO:0007283]; telomerase RNA stabilization [GO:0090669]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18854321}. Cytoplasm {ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18854321}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8VHK9}. Cytoplasm, Stress granule {ECO:0000269|PubMed:18854321}. Nucleus speckle {ECO:0000269|PubMed:18279852}. Chromosome, telomere {ECO:0000269|PubMed:20472641}. Mitochondrion {ECO:0000250|UniProtKB:Q8VHK9}. Perikaryon {ECO:0000250|UniProtKB:D4A2Z8}. Cell projection, dendrite {ECO:0000250|UniProtKB:D4A2Z8}. Cell projection, axon {ECO:0000250|UniProtKB:D4A2Z8}. Note=Predominantly localized in the nucleus (PubMed:18279852). Colocalizes with SRSF2 in nuclear speckles (PubMed:18279852). Colocalizes with DDX5 in nucleolar caps upon transcription inhibition (PubMed:18279852). Accumulates and colocalized with TIA1 in cytoplasmic stress granules (SGs) in an arsenite-, heat shock- and RNA-binding-dependent manner (PubMed:18854321). Shuttles into and out of SGs in an ATPase-dependent manner (PubMed:18854321). Colocalizes in the cytosol with the multi-helicase-TICAM1 complex that translocates to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity). {ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18854321}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:14731398}. Cytoplasm {ECO:0000269|PubMed:14731398}. Note=Preferentially localized in the nucleus (PubMed:14731398). Excluded from nucleoli (PubMed:14731398). {ECO:0000269|PubMed:14731398}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:14731398}. Cytoplasm {ECO:0000269|PubMed:14731398}. Note=Preferentially localized in the cytoplasm (PubMed:14731398). Excluded from nucleoli (PubMed:14731398). {ECO:0000269|PubMed:14731398}.
Q9H2U2	reviewed	IPYR2_HUMAN	Inorganic pyrophosphatase 2, mitochondrial (EC 3.6.1.1) (Pyrophosphatase SID6-306) (Pyrophosphate phospho-hydrolase 2) (PPase 2)	PPA2 HSPC124	Homo sapiens (Human)	334	FUNCTION: Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598). {ECO:0000269|PubMed:27523597, ECO:0000269|PubMed:27523598}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	diphosphate metabolic process [GO:0071344]; phosphate-containing compound metabolic process [GO:0006796]; regulation of mitochondrial membrane potential [GO:0051881]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; synapse [GO:0045202]	inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]; protein serine/threonine phosphatase activity [GO:0004722]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; synapse [GO:0045202]; inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]; protein serine/threonine phosphatase activity [GO:0004722]; diphosphate metabolic process [GO:0071344]; phosphate-containing compound metabolic process [GO:0006796]; regulation of mitochondrial membrane potential [GO:0051881]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:27523597}.
Q9H2U9	reviewed	ADAM7_HUMAN	Disintegrin and metalloproteinase domain-containing protein 7 (ADAM 7) (Sperm maturation-related glycoprotein GP-83)	ADAM7 GP83	Homo sapiens (Human)	754	FUNCTION: Required for normal male fertility via maintenance of epithelial cell morphology in the caput epididymis and subsequently correct epididymis lumen structure required for sperm development (By similarity). Plays a role in sperm motility, flagella morphology and tyrosine phosphorylation during sperm capacitance (By similarity). Plays a role in normal expression levels of HSPA5, ITM2B and ADAM2 in sperm both prior to and post-capacitation (By similarity). This is a non catalytic metalloprotease-like protein (By similarity). {ECO:0000250|UniProtKB:O35227}.		proteolysis [GO:0006508]	plasma membrane [GO:0005886]	metalloendopeptidase activity [GO:0004222]	plasma membrane [GO:0005886]; metalloendopeptidase activity [GO:0004222]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
Q9H2V7	reviewed	SPNS1_HUMAN	Protein spinster homolog 1 (HSpin1) (SPNS1) (Spinster-like protein 1)	SPNS1 SPIN1 PP20300	Homo sapiens (Human)	528	FUNCTION: Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949, PubMed:37075117). Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids (PubMed:36161949, PubMed:37075117). Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin (PubMed:36161949). Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3-phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively (PubMed:36161949, PubMed:37075117). Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine (PubMed:36161949). Lysosomal LPC could function as intracellular signaling messenger (PubMed:37075117). Essential player in lysosomal homeostasis (PubMed:36161949). Crucial for cell survival under conditions of nutrient limitation (PubMed:37075117). May be involved in necrotic or autophagic cell death (PubMed:12815463). {ECO:0000269|PubMed:12815463, ECO:0000269|PubMed:36161949, ECO:0000269|PubMed:37075117, ECO:0000303|PubMed:37075117}.		lysophospholipid transport [GO:0051977]; phospholipid efflux [GO:0033700]; regulation of lysosomal lumen pH [GO:0035751]	lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]	transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; transmembrane transporter activity [GO:0022857]; lysophospholipid transport [GO:0051977]; phospholipid efflux [GO:0033700]; regulation of lysosomal lumen pH [GO:0035751]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:12408844}; Multi-pass membrane protein {ECO:0000269|PubMed:12408844}. Mitochondrion inner membrane {ECO:0000269|PubMed:12815463}; Multi-pass membrane protein {ECO:0000269|PubMed:12815463}. Note=Ocassionally localizes to mitochondria. {ECO:0000269|PubMed:12815463}.
Q9H2W1	reviewed	M4A6A_HUMAN	Membrane-spanning 4-domains subfamily A member 6A (CD20 antigen-like 3) (Four-span transmembrane protein 3)	MS4A6A 4SPAN3 CD20L3 MS4A6 CDA01 MSTP090	Homo sapiens (Human)	248	FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex.		cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]		plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9H2W2	reviewed	MIXL1_HUMAN	Homeobox protein MIXL1 (Homeodomain protein MIX) (hMix) (MIX1 homeobox-like protein 1) (Mix.1 homeobox-like protein)	MIXL1 MIXL	Homo sapiens (Human)	232	FUNCTION: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). {ECO:0000250}.		cell migration involved in gastrulation [GO:0042074]; digestive tract development [GO:0048565]; endoderm development [GO:0007492]; endoderm formation [GO:0001706]; endodermal cell differentiation [GO:0035987]; gastrulation [GO:0007369]; heart development [GO:0007507]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; positive regulation of mesoderm development [GO:2000382]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; cell migration involved in gastrulation [GO:0042074]; digestive tract development [GO:0048565]; endoderm development [GO:0007492]; endoderm formation [GO:0001706]; endodermal cell differentiation [GO:0035987]; gastrulation [GO:0007369]; heart development [GO:0007507]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; positive regulation of mesoderm development [GO:2000382]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12070013, ECO:0000269|PubMed:17303500}.
Q9H2X0	reviewed	CHRD_HUMAN	Chordin	CHRD UNQ217/PRO243	Homo sapiens (Human)	955	FUNCTION: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	BMP signaling pathway [GO:0030509]; dorsal/ventral pattern formation [GO:0009953]; floor plate development [GO:0033504]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell migration [GO:0030336]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of cell adhesion [GO:0045785]; positive regulation of mesenchymal cell proliferation [GO:0002053]; skeletal system development [GO:0001501]; spinal cord dorsal/ventral patterning [GO:0021513]	extracellular space [GO:0005615]	BMP binding [GO:0036122]; cytokine binding [GO:0019955]	extracellular space [GO:0005615]; BMP binding [GO:0036122]; cytokine binding [GO:0019955]; BMP signaling pathway [GO:0030509]; dorsal/ventral pattern formation [GO:0009953]; floor plate development [GO:0033504]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell migration [GO:0030336]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of cell adhesion [GO:0045785]; positive regulation of mesenchymal cell proliferation [GO:0002053]; skeletal system development [GO:0001501]; spinal cord dorsal/ventral patterning [GO:0021513]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q9H2X3	reviewed	CLC4M_HUMAN	C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299)	CLEC4M CD209L CD209L1 CD299	Homo sapiens (Human)	399	FUNCTION: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. {ECO:0000269|PubMed:11257134}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Ebolavirus. {ECO:0000269|PubMed:12050398, ECO:0000269|PubMed:12502850}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Hepatitis C virus. {ECO:0000269|PubMed:15371595, ECO:0000269|PubMed:16816373}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for HIV-1. {ECO:0000269|PubMed:12502850, ECO:0000269|PubMed:21203928}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E. {ECO:0000269|PubMed:17037540}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5. {ECO:0000269|PubMed:12433371}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Influenzavirus. {ECO:0000269|PubMed:21191006}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for SARS-CoV. {ECO:0000269|PubMed:15479853}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for West-nile virus. {ECO:0000269|PubMed:15479853}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. {ECO:0000269|PubMed:24623090}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein. {ECO:0000269|PubMed:15479853}.; FUNCTION: (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule. {ECO:0000269|PubMed:21277928}.	MISCELLANEOUS: In vitro, is a receptor for HIV-1 and transmits HIV-1 to permissive T-cells.; MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: May be due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Non-canonical intron-exon splice junction. {ECO:0000305}.; MISCELLANEOUS: [Isoform 10]: May be due to intron retention. {ECO:0000305}.	adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; cell-cell recognition [GO:0009988]; immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intracellular transport of virus [GO:0075733]; leukocyte cell-cell adhesion [GO:0007159]; peptide antigen transport [GO:0046968]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; receptor-mediated virion attachment to host cell [GO:0046813]; viral entry into host cell [GO:0046718]; viral genome replication [GO:0019079]; virion attachment to host cell [GO:0019062]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; host cell [GO:0043657]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium-dependent protein binding [GO:0048306]; carbohydrate binding [GO:0030246]; ICAM-3 receptor activity [GO:0030369]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]; peptide antigen binding [GO:0042605]; signaling receptor activity [GO:0038023]; virion binding [GO:0046790]; virus receptor activity [GO:0001618]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; host cell [GO:0043657]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium-dependent protein binding [GO:0048306]; carbohydrate binding [GO:0030246]; ICAM-3 receptor activity [GO:0030369]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]; peptide antigen binding [GO:0042605]; signaling receptor activity [GO:0038023]; virion binding [GO:0046790]; virus receptor activity [GO:0001618]; adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; cell-cell recognition [GO:0009988]; immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intracellular transport of virus [GO:0075733]; leukocyte cell-cell adhesion [GO:0007159]; peptide antigen transport [GO:0046968]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; receptor-mediated virion attachment to host cell [GO:0046813]; viral entry into host cell [GO:0046718]; viral genome replication [GO:0019079]; virion attachment to host cell [GO:0019062]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 10]: Secreted {ECO:0000305}.
Q9H2X6	reviewed	HIPK2_HUMAN	Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)	HIPK2	Homo sapiens (Human)	1198	FUNCTION: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}.	MISCELLANEOUS: Interesting targets for cancer therapy. HIPK2 deregulation would end up in a multifactorial response leading to tumor chemoresistance by affecting p53/TP53 activity on one hand and to angiogenesis and cell proliferation by affecting HIF1A activity on the other hand. May provide important insights in the process of tumor progression, and may also serve as the crucial point in the diagnostic and therapeutical aspects of cancer. Tumor treatment may potential be improved by zinc supplementation in combination with chemotherapy to address hypoxia (PubMed:20514025). {ECO:0000305|PubMed:20514025}.	adult walking behavior [GO:0007628]; anterior/posterior pattern specification [GO:0009952]; cell population proliferation [GO:0008283]; cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; epigenetic regulation of gene expression [GO:0040029]; erythrocyte differentiation [GO:0030218]; eye development [GO:0001654]; gene expression [GO:0010467]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; iris morphogenesis [GO:0061072]; lens induction in camera-type eye [GO:0060235]; lung morphogenesis [GO:0060425]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; PML body organization [GO:0030578]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; respiratory system process [GO:0003016]; retina layer formation [GO:0010842]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; thyroid gland development [GO:0030878]; transforming growth factor beta receptor signaling pathway [GO:0007179]; voluntary musculoskeletal movement [GO:0050882]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; RNA polymerase II transcription regulator complex [GO:0090575]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; virion binding [GO:0046790]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; RNA polymerase II transcription regulator complex [GO:0090575]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; virion binding [GO:0046790]; adult walking behavior [GO:0007628]; anterior/posterior pattern specification [GO:0009952]; cell population proliferation [GO:0008283]; cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; epigenetic regulation of gene expression [GO:0040029]; erythrocyte differentiation [GO:0030218]; eye development [GO:0001654]; gene expression [GO:0010467]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; iris morphogenesis [GO:0061072]; lens induction in camera-type eye [GO:0060235]; lung morphogenesis [GO:0060425]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; PML body organization [GO:0030578]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; respiratory system process [GO:0003016]; retina layer formation [GO:0010842]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; thyroid gland development [GO:0030878]; transforming growth factor beta receptor signaling pathway [GO:0007179]; voluntary musculoskeletal movement [GO:0050882]	SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000269|PubMed:27211601, ECO:0000269|PubMed:33591310}. Cytoplasm {ECO:0000269|PubMed:33591310}. Cytoplasm, Stress granule {ECO:0000269|PubMed:33591310}. Note=Concentrated in PML/POD/ND10 nuclear bodies. Small amounts are cytoplasmic.
Q9H2X9	reviewed	S12A5_HUMAN	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter)	SLC12A5 KCC2 KIAA1176	Homo sapiens (Human)	1139	FUNCTION: Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:12106695). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). {ECO:0000250|UniProtKB:Q63633, ECO:0000269|PubMed:12106695, ECO:0000269|PubMed:24668262}.	MISCELLANEOUS: Inhibited by furosemide and bumetanide.	cell volume homeostasis [GO:0006884]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; dendritic spine development [GO:0060996]; hypotonic response [GO:0006971]; intracellular chloride ion homeostasis [GO:0030644]; intracellular pH reduction [GO:0051452]; learning [GO:0007612]; monoatomic ion transport [GO:0006811]; multicellular organism growth [GO:0035264]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; response to xenobiotic stimulus [GO:0009410]; thermosensory behavior [GO:0040040]	cell periphery [GO:0071944]; dendrite membrane [GO:0032590]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202]	ammonium transmembrane transporter activity [GO:0008519]; chloride transmembrane transporter activity [GO:0015108]; metal ion binding [GO:0046872]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901]	cell periphery [GO:0071944]; dendrite membrane [GO:0032590]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202]; ammonium transmembrane transporter activity [GO:0008519]; chloride transmembrane transporter activity [GO:0015108]; metal ion binding [GO:0046872]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901]; cell volume homeostasis [GO:0006884]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; dendritic spine development [GO:0060996]; hypotonic response [GO:0006971]; intracellular chloride ion homeostasis [GO:0030644]; intracellular pH reduction [GO:0051452]; learning [GO:0007612]; monoatomic ion transport [GO:0006811]; multicellular organism growth [GO:0035264]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; response to xenobiotic stimulus [GO:0009410]; thermosensory behavior [GO:0040040]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q91V14}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91V14}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q91V14}. Note=Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses. {ECO:0000250|UniProtKB:Q91V14}.
Q9H2Y7	reviewed	ZN106_HUMAN	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474)	ZNF106 SH3BP3 ZFP106 ZNF474	Homo sapiens (Human)	1883	FUNCTION: RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}.		insulin receptor signaling pathway [GO:0008286]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]; insulin receptor signaling pathway [GO:0008286]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:O88466}. Nucleus speckle {ECO:0000250|UniProtKB:O88466}. Note=Colocalizes with RBM39 in nuclear speckles. Inhibition of RNA synthesis, or overexpression of KNOP1, induces translocation from nuclear speckles to the nucleolus. {ECO:0000250|UniProtKB:O88466}.
Q9H300	reviewed	PARL_HUMAN	Presenilin-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) (Mitochondrial intramembrane cleaving protease PARL) [Cleaved into: P-beta (Pbeta)]	PARL PSARL PRO2207	Homo sapiens (Human)	379	FUNCTION: Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088). Promotes cleavage of serine/threonine-protein phosphatase PGAM5 in damaged mitochondria in response to loss of mitochondrial membrane potential (PubMed:22915595). Mediates differential cleavage of PINK1 and PGAM5 depending on the health status of mitochondria, disassociating from PINK1 and associating with PGAM5 in response to mitochondrial membrane potential loss (PubMed:22915595). Required for processing of CLPB into a form with higher protein disaggregase activity by removing an autoinhibitory N-terminal peptide (PubMed:28288130, PubMed:32573439). Promotes processing of DIABLO/SMAC in the mitochondrion which is required for DIABLO apoptotic activity (PubMed:28288130). Also required for cleavage of STARD7 and TTC19 (PubMed:28288130). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (PubMed:14732705, PubMed:17116872). {ECO:0000250|UniProtKB:Q5XJY4, ECO:0000269|PubMed:14732705, ECO:0000269|PubMed:17116872, ECO:0000269|PubMed:22354088, ECO:0000269|PubMed:22915595, ECO:0000269|PubMed:28288130, ECO:0000269|PubMed:32573439}.		membrane protein proteolysis [GO:0033619]; mitochondrial fusion [GO:0008053]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; proteolysis [GO:0006508]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of mitochondrion organization [GO:0010821]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of proteolysis [GO:0030162]; regulation of reactive oxygen species metabolic process [GO:2000377]; signal peptide processing [GO:0006465]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252]; membrane protein proteolysis [GO:0033619]; mitochondrial fusion [GO:0008053]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; proteolysis [GO:0006508]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of mitochondrion organization [GO:0010821]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of proteolysis [GO:0030162]; regulation of reactive oxygen species metabolic process [GO:2000377]; signal peptide processing [GO:0006465]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:17116872, ECO:0000269|PubMed:22354088}; Multi-pass membrane protein {ECO:0000269|PubMed:17116872}.; SUBCELLULAR LOCATION: [P-beta]: Nucleus {ECO:0000269|PubMed:17116872}. Note=Translocated into the nucleus by an unknown mechanism (PubMed:17116872). {ECO:0000269|PubMed:17116872}.
Q9H305	reviewed	CDIP1_HUMAN	Cell death-inducing p53-target protein 1 (Cell death involved p53-target) (Cell death-inducing protein) (LITAF-like protein) (Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein) (Transmembrane protein I1)	CDIP1 C16orf5 CDIP LITAFL	Homo sapiens (Human)	208	FUNCTION: Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner. {ECO:0000269|PubMed:17599062}.	MISCELLANEOUS: [Isoform 2]: May be due to competing acceptor splice site. {ECO:0000305}.	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]	cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; nucleus [GO:0005634]	zinc ion binding [GO:0008270]	cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; nucleus [GO:0005634]; zinc ion binding [GO:0008270]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:27582497}; Peripheral membrane protein {ECO:0000269|PubMed:27582497}; Cytoplasmic side {ECO:0000269|PubMed:27582497}. Lysosome membrane {ECO:0000269|PubMed:27582497}; Peripheral membrane protein {ECO:0000269|PubMed:27582497}; Cytoplasmic side {ECO:0000269|PubMed:27582497}.
Q9H306	reviewed	MMP27_HUMAN	Matrix metalloproteinase-27 (MMP-27) (EC 3.4.24.-)	MMP27 UNQ2503/PRO5992	Homo sapiens (Human)	513	FUNCTION: Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens. {ECO:0000250}.		collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000269|PubMed:24548619}. Note=Retained in the endoplasmic reticulum. {ECO:0000269|PubMed:24548619}.
Q9H307	reviewed	PININ_HUMAN	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein)	PNN DRS MEMA	Homo sapiens (Human)	717	FUNCTION: Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. {ECO:0000269|PubMed:12051732, ECO:0000269|PubMed:14517304, ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:15735603, ECO:0000269|PubMed:22388736}.		cell adhesion [GO:0007155]; mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; cell-cell junction [GO:0005911]; desmosome [GO:0030057]; intermediate filament [GO:0005882]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]	catalytic step 2 spliceosome [GO:0071013]; cell-cell junction [GO:0005911]; desmosome [GO:0030057]; intermediate filament [GO:0005882]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; cell adhesion [GO:0007155]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus speckle. Cell junction, desmosome. Note=Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
Q9H310	reviewed	RHBG_HUMAN	Ammonium transporter Rh type B (Rhesus blood group family type B glycoprotein) (Rh family type B glycoprotein) (Rh type B glycoprotein)	RHBG	Homo sapiens (Human)	458	FUNCTION: Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport (PubMed:15284342, PubMed:15929723, PubMed:24077989). May act as a CO2 channel providing for renal acid secretion (PubMed:24077989). {ECO:0000269|PubMed:15284342, ECO:0000269|PubMed:15929723, ECO:0000269|PubMed:24077989}.		ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]; transepithelial ammonium transport [GO:0070634]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; spectrin-associated cytoskeleton [GO:0014731]	ammonium transmembrane transporter activity [GO:0008519]; ankyrin binding [GO:0030506]; carbon dioxide transmembrane transporter activity [GO:0035379]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; spectrin-associated cytoskeleton [GO:0014731]; ammonium transmembrane transporter activity [GO:0008519]; ankyrin binding [GO:0030506]; carbon dioxide transmembrane transporter activity [GO:0035379]; ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]; transepithelial ammonium transport [GO:0070634]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11024028, ECO:0000269|PubMed:15929723}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:15611082}; Multi-pass membrane protein {ECO:0000255}.
Q9H313	reviewed	TTYH1_HUMAN	Protein tweety homolog 1 (hTTY1)	TTYH1	Homo sapiens (Human)	450	FUNCTION: Probable chloride channel. May be involved in cell adhesion (By similarity). {ECO:0000250}.; FUNCTION: Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in regulation of cell volume.		cell-cell adhesion [GO:0098609]; cell-substrate adhesion [GO:0031589]; chloride transport [GO:0006821]; filopodium assembly [GO:0046847]; iron ion transport [GO:0006826]; mitotic cell cycle [GO:0000278]; monoatomic ion transmembrane transport [GO:0034220]	chloride channel complex [GO:0034707]; filopodium membrane [GO:0031527]; filopodium tip [GO:0032433]; membrane [GO:0016020]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; synapse [GO:0045202]	calcium ion binding [GO:0005509]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; iron ion transmembrane transporter activity [GO:0005381]; volume-sensitive chloride channel activity [GO:0072320]	chloride channel complex [GO:0034707]; filopodium membrane [GO:0031527]; filopodium tip [GO:0032433]; membrane [GO:0016020]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; iron ion transmembrane transporter activity [GO:0005381]; volume-sensitive chloride channel activity [GO:0072320]; cell-cell adhesion [GO:0098609]; cell-substrate adhesion [GO:0031589]; chloride transport [GO:0006821]; filopodium assembly [GO:0046847]; iron ion transport [GO:0006826]; mitotic cell cycle [GO:0000278]; monoatomic ion transmembrane transport [GO:0034220]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9H320	reviewed	VCX1_HUMAN	Variable charge X-linked protein 1 (Variable charge protein on X with ten repeats) (VCX-10r) (Variably charged protein X-B1) (VCX-B1)	VCX VCX1 VCX10R VCXB1	Homo sapiens (Human)	206	FUNCTION: May mediate a process in spermatogenesis or may play a role in sex ratio distortion.		brain development [GO:0007420]; chromatin organization [GO:0006325]; ribosome assembly [GO:0042255]; spermatogenesis [GO:0007283]	nucleolus [GO:0005730]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	nucleolus [GO:0005730]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; brain development [GO:0007420]; chromatin organization [GO:0006325]; ribosome assembly [GO:0042255]; spermatogenesis [GO:0007283]	
Q9H324	reviewed	ATS10_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAM-TS 10) (ADAM-TS10) (ADAMTS-10) (EC 3.4.24.-)	ADAMTS10	Homo sapiens (Human)	1103	FUNCTION: Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. {ECO:0000269|PubMed:21402694}.		extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:21402694}.
Q9H329	reviewed	E41LB_HUMAN	Band 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (FERM-containing protein CG1) (Protein EHM2)	EPB41L4B EHM2 LULU2	Homo sapiens (Human)	900	FUNCTION: Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927). {ECO:0000250|UniProtKB:Q9JMC8, ECO:0000269|PubMed:14521927, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:23664528}.		actomyosin structure organization [GO:0031032]; positive regulation of cell adhesion [GO:0045785]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte migration [GO:0051549]; wound healing [GO:0042060]	apical part of cell [GO:0045177]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	cytoskeletal protein binding [GO:0008092]; structural constituent of cytoskeleton [GO:0005200]	apical part of cell [GO:0045177]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; cytoskeletal protein binding [GO:0008092]; structural constituent of cytoskeleton [GO:0005200]; actomyosin structure organization [GO:0031032]; positive regulation of cell adhesion [GO:0045785]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte migration [GO:0051549]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22006950}. Cell junction, tight junction {ECO:0000269|PubMed:22006950}. Note=Accumulates along apical cell-cell boundaries and is also detected in the cytoplasm in a punctate manner. {ECO:0000269|PubMed:22006950}.
Q9H334	reviewed	FOXP1_HUMAN	Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH)	FOXP1 HSPC215	Homo sapiens (Human)	677	FUNCTION: Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}.	MISCELLANEOUS: [Isoform 3]: Incomplete sequence. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Incomplete sequence. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: May be due to competing acceptor splice site. {ECO:0000305}.	cellular response to tumor necrosis factor [GO:0071356]; DNA damage response [GO:0006974]; endothelial cell activation [GO:0042118]; macrophage activation [GO:0042116]; monocyte activation [GO:0042117]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; osteoclast development [GO:0036035]; osteoclast differentiation [GO:0030316]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of interleukin-21 production [GO:0032745]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of defense response to bacterium [GO:1900424]; regulation of endothelial tube morphogenesis [GO:1901509]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-1 beta production [GO:0032651]; regulation of interleukin-12 production [GO:0032655]; regulation of macrophage colony-stimulating factor production [GO:1901256]; regulation of monocyte differentiation [GO:0045655]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tumor necrosis factor production [GO:0032680]; response to lipopolysaccharide [GO:0032496]; response to testosterone [GO:0033574]; striatum development [GO:0021756]; T follicular helper cell differentiation [GO:0061470]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; protein self-association [GO:0043621]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; protein self-association [GO:0043621]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to tumor necrosis factor [GO:0071356]; DNA damage response [GO:0006974]; endothelial cell activation [GO:0042118]; macrophage activation [GO:0042116]; monocyte activation [GO:0042117]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; osteoclast development [GO:0036035]; osteoclast differentiation [GO:0030316]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of interleukin-21 production [GO:0032745]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of defense response to bacterium [GO:1900424]; regulation of endothelial tube morphogenesis [GO:1901509]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-1 beta production [GO:0032651]; regulation of interleukin-12 production [GO:0032655]; regulation of macrophage colony-stimulating factor production [GO:1901256]; regulation of monocyte differentiation [GO:0045655]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tumor necrosis factor production [GO:0032680]; response to lipopolysaccharide [GO:0032496]; response to testosterone [GO:0033574]; striatum development [GO:0021756]; T follicular helper cell differentiation [GO:0061470]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25027557, ECO:0000269|PubMed:26647308}. Note=Not found in the nucleolus. {ECO:0000269|PubMed:26647308}.
Q9H361	reviewed	PABP3_HUMAN	Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein)	PABPC3 PABP3 PABPL3	Homo sapiens (Human)	631	FUNCTION: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.		mRNA metabolic process [GO:0016071]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; mRNA metabolic process [GO:0016071]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9H3D4	reviewed	P63_HUMAN	Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)	TP63 KET P63 P73H P73L TP73L	Homo sapiens (Human)	680	FUNCTION: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:9774969}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative splicing of isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Produced by alternative splicing of isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 10]: Produced by alternative splicing of isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 11]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 12]: Produced by alternative splicing of isoform 2. {ECO:0000305}.	apoptotic process [GO:0006915]; cellular senescence [GO:0090398]; chromatin remodeling [GO:0006338]; cloacal septation [GO:0060197]; cranial skeletal system development [GO:1904888]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; ectoderm and mesoderm interaction [GO:0007499]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; epidermal cell division [GO:0010481]; epithelial cell development [GO:0002064]; establishment of planar polarity [GO:0001736]; establishment of skin barrier [GO:0061436]; female genitalia morphogenesis [GO:0048807]; hair follicle morphogenesis [GO:0031069]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of mesoderm development [GO:2000381]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of somatic stem cell population maintenance [GO:1904674]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; prostatic bud formation [GO:0060513]; protein tetramerization [GO:0051262]; proximal/distal pattern formation [GO:0009954]; regulation of epidermal cell division [GO:0010482]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; skin morphogenesis [GO:0043589]; spermatogenesis [GO:0007283]; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529]; stem cell proliferation [GO:0072089]; sympathetic nervous system development [GO:0048485]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; WW domain binding [GO:0050699]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; WW domain binding [GO:0050699]; apoptotic process [GO:0006915]; cellular senescence [GO:0090398]; chromatin remodeling [GO:0006338]; cloacal septation [GO:0060197]; cranial skeletal system development [GO:1904888]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; ectoderm and mesoderm interaction [GO:0007499]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; epidermal cell division [GO:0010481]; epithelial cell development [GO:0002064]; establishment of planar polarity [GO:0001736]; establishment of skin barrier [GO:0061436]; female genitalia morphogenesis [GO:0048807]; hair follicle morphogenesis [GO:0031069]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of mesoderm development [GO:2000381]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of somatic stem cell population maintenance [GO:1904674]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; prostatic bud formation [GO:0060513]; protein tetramerization [GO:0051262]; proximal/distal pattern formation [GO:0009954]; regulation of epidermal cell division [GO:0010482]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; skin morphogenesis [GO:0043589]; spermatogenesis [GO:0007283]; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529]; stem cell proliferation [GO:0072089]; sympathetic nervous system development [GO:0048485]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:20123734}.
Q9H3F6	reviewed	BACD3_HUMAN	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (hBACURD3) (BTB/POZ domain-containing protein KCTD10) (Potassium channel tetramerization domain-containing protein 10)	KCTD10 ULR061 MSTP028	Homo sapiens (Human)	313	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:Q8WZ19}.		negative regulation of Rho protein signal transduction [GO:0035024]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]; Notch binding [GO:0005112]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; Notch binding [GO:0005112]; negative regulation of Rho protein signal transduction [GO:0035024]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19125419}.
Q9H3H1	reviewed	MOD5_HUMAN	tRNA dimethylallyltransferase (EC 2.5.1.75) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (hGRO1) (tRNA isopentenyltransferase 1) (IPTase)	TRIT1 IPT MOD5	Homo sapiens (Human)	467	FUNCTION: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) (PubMed:11111046, PubMed:24126054, PubMed:24901367, PubMed:34774131). Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) (PubMed:24126054). TRIT1 is therefore required for selenoprotein expression (PubMed:24126054). {ECO:0000269|PubMed:11111046, ECO:0000269|PubMed:24126054, ECO:0000269|PubMed:24901367, ECO:0000269|PubMed:34774131}.		mitochondrial tRNA modification [GO:0070900]; tRNA modification [GO:0006400]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]; tRNA dimethylallyltransferase activity [GO:0052381]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]; tRNA dimethylallyltransferase activity [GO:0052381]; zinc ion binding [GO:0008270]; mitochondrial tRNA modification [GO:0070900]; tRNA modification [GO:0006400]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:24901367}.; SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.
Q9H3H3	reviewed	CK068_HUMAN	UPF0696 protein C11orf68 (Basophilic leukemia-expressed protein Bles03) (Protein p5326)	C11orf68 BLES03	Homo sapiens (Human)	292		MISCELLANEOUS: [Isoform 1]: Dubious isoform based on intron retention. {ECO:0000305}.			RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q9H3H5	reviewed	GPT_HUMAN	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) (GlcNAc-1-P transferase) (G1PT) (GPT) (N-acetylglucosamine-1-phosphate transferase)	DPAGT1 DPAGT2	Homo sapiens (Human)	408	FUNCTION: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol. {ECO:0000269|PubMed:29459785, ECO:0000269|PubMed:30388443, ECO:0000269|PubMed:9451016}.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine metabolic process [GO:0006047]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	glycosyltransferase activity [GO:0016757]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity [GO:0003975]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; glycosyltransferase activity [GO:0016757]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity [GO:0003975]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine metabolic process [GO:0006047]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000269|PubMed:29459785, ECO:0000269|PubMed:30388443}.
Q9H3J6	reviewed	MTRFR_HUMAN	Mitochondrial translation release factor in rescue	MTRFR C12orf65 My030	Homo sapiens (Human)	166	FUNCTION: Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:33243891). As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891). {ECO:0000269|PubMed:33243891}.		rescue of stalled ribosome [GO:0072344]	mitochondrion [GO:0005739]	ribosomal large subunit binding [GO:0043023]; translation release factor activity [GO:0003747]; tRNA binding [GO:0000049]	mitochondrion [GO:0005739]; ribosomal large subunit binding [GO:0043023]; translation release factor activity [GO:0003747]; tRNA binding [GO:0000049]; rescue of stalled ribosome [GO:0072344]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20186120, ECO:0000269|PubMed:20598281}.
Q9H3K2	reviewed	GHITM_HUMAN	Growth hormone-inducible transmembrane protein (Dermal papilla-derived protein 2) (Mitochondrial morphology and cristae structure 1) (MICS1) (Transmembrane BAX inhibitor motif-containing protein 5)	GHITM DERP2 MICS1 TMBIM5 My021 UNQ244/PRO281	Homo sapiens (Human)	345	FUNCTION: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:18417609, PubMed:36321428, PubMed:32977469, PubMed:35912435). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:36321428, PubMed:35912435). Functions also as an electroneutral mitochondrial proton/potassium exchanger (PubMed:36321428). Required for the mitochondrial tubular network and cristae organization (PubMed:18417609, PubMed:36321428, PubMed:32977469). Involved in apoptotic release of cytochrome c (PubMed:18417609). Inhibits the proteolytic activity of AFG3L2, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (PubMed:36321428). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now the active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome (PubMed:36321428). {ECO:0000269|PubMed:18417609, ECO:0000269|PubMed:35912435, ECO:0000269|PubMed:36321428}.		apoptotic process [GO:0006915]; calcium export from the mitochondrion [GO:0099093]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrial potassium ion transmembrane transport [GO:0140141]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	calcium:proton antiporter activity [GO:0015369]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; calcium:proton antiporter activity [GO:0015369]; apoptotic process [GO:0006915]; calcium export from the mitochondrion [GO:0099093]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrial potassium ion transmembrane transport [GO:0140141]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:18417609}; Multi-pass membrane protein {ECO:0000255}.
Q9H3K6	reviewed	BOLA2_HUMAN	BolA-like protein 2	BOLA2 BOLA2A My016; BOLA2B	Homo sapiens (Human)	86	FUNCTION: Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415). {ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	[2Fe-2S] cluster assembly [GO:0044571]; cell redox homeostasis [GO:0045454]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; nucleus [GO:0005634]	2 iron, 2 sulfur cluster binding [GO:0051537]; iron-sulfur cluster binding [GO:0051536]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; nucleus [GO:0005634]; 2 iron, 2 sulfur cluster binding [GO:0051537]; iron-sulfur cluster binding [GO:0051536]; [2Fe-2S] cluster assembly [GO:0044571]; cell redox homeostasis [GO:0045454]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22746225}. Nucleus {ECO:0000269|PubMed:22746225}.
Q9H3L0	reviewed	MMAD_HUMAN	Cobalamin trafficking protein CblD (CblD) (Methylmalonic aciduria and homocystinuria type D protein, mitochondrial)	MMADHC C2orf25 CL25022 HSPC161 My011	Homo sapiens (Human)	296	FUNCTION: Involved in cobalamin metabolism and trafficking (PubMed:18385497, PubMed:23415655, PubMed:24722857, PubMed:26364851). Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl) (PubMed:18385497, PubMed:23415655, PubMed:24722857). Promotes oxidation of cob(II)alamin bound to MMACHC (PubMed:26364851). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510). {ECO:0000269|PubMed:18385497, ECO:0000269|PubMed:23415655, ECO:0000269|PubMed:24722857, ECO:0000269|PubMed:26364851, ECO:0000269|PubMed:27771510}.		cobalamin metabolic process [GO:0009235]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; cobalamin metabolic process [GO:0009235]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23270877}. Mitochondrion {ECO:0000269|PubMed:23270877}.
Q9H3M0	reviewed	KCNF1_HUMAN	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1)	KCNF1	Homo sapiens (Human)	494	FUNCTION: Putative voltage-gated potassium channel.		non-motile cilium assembly [GO:1905515]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	ciliary base [GO:0097546]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	potassium channel activity [GO:0005267]; voltage-gated potassium channel activity [GO:0005249]	ciliary base [GO:0097546]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; potassium channel activity [GO:0005267]; voltage-gated potassium channel activity [GO:0005249]; non-motile cilium assembly [GO:1905515]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9H3M7	reviewed	TXNIP_HUMAN	Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)	TXNIP VDUP1	Homo sapiens (Human)	391	FUNCTION: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). {ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}.		cell cycle [GO:0007049]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to tumor cell [GO:0071228]; inflammatory response [GO:0006954]; keratinocyte differentiation [GO:0030216]; negative regulation of cell division [GO:0051782]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of apoptotic process [GO:0043065]; protein import into nucleus [GO:0006606]; protein transport [GO:0015031]; regulation of cell population proliferation [GO:0042127]; response to calcium ion [GO:0051592]; response to estradiol [GO:0032355]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	enzyme inhibitor activity [GO:0004857]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; enzyme inhibitor activity [GO:0004857]; ubiquitin protein ligase binding [GO:0031625]; cell cycle [GO:0007049]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to tumor cell [GO:0071228]; inflammatory response [GO:0006954]; keratinocyte differentiation [GO:0030216]; negative regulation of cell division [GO:0051782]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of apoptotic process [GO:0043065]; protein import into nucleus [GO:0006606]; protein transport [GO:0015031]; regulation of cell population proliferation [GO:0042127]; response to calcium ion [GO:0051592]; response to estradiol [GO:0032355]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9H3N1	reviewed	TMX1_HUMAN	Thioredoxin-related transmembrane protein 1 (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein)	TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268	Homo sapiens (Human)	280	FUNCTION: May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.		response to endoplasmic reticulum stress [GO:0034976]	endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]	disulfide oxidoreductase activity [GO:0015036]	endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; disulfide oxidoreductase activity [GO:0015036]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly found in the endoplasmic reticulum. {ECO:0000269|PubMed:11152479}.
Q9H3N8	reviewed	HRH4_HUMAN	Histamine H4 receptor (H4R) (HH4R) (AXOR35) (G-protein coupled receptor 105) (GPRv53) (Pfi-013) (SP9144)	HRH4 GPCR105	Homo sapiens (Human)	390	FUNCTION: The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). {ECO:0000269|PubMed:12503632}.	MISCELLANEOUS: Does not bind diphenhydramine, loratadine, ranitidine, cimetidine and chlorpheniramine. Shows modest affinity for dimaprit, impromidine, clobenpropit, thioperamide, burimamide clozapine, immepip and imetit. The order of inhibitory activity was imetit > clobenpropit > burimamide > thioperamide. Clobenpropit behaves as a partial agonist, dimaprit and impromidine show some agonist activity while clozapine behaves as a full agonist. Thioperamide shows inverse agonism (enhances cAMP activity). The order of inhibitory activity of histamine derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha-methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha-methylhistamine > R(-)-alpha-methylhistamine behave as full agonists.	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of MAPK cascade [GO:0043408]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of MAPK cascade [GO:0043408]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H3P2	reviewed	NELFA_HUMAN	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein)	NELFA WHSC2 P/OKcl.15	Homo sapiens (Human)	528	FUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}.		negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytosol [GO:0005829]; NELF complex [GO:0032021]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090]	cytosol [GO:0005829]; NELF complex [GO:0032021]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11150502}.
Q9H3P7	reviewed	GCP60_HUMAN	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed]	ACBD3 GCP60 GOCAP1 GOLPH1	Homo sapiens (Human)	528	FUNCTION: Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.		steroid biosynthetic process [GO:0006694]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrion [GO:0005739]	fatty-acyl-CoA binding [GO:0000062]; protein kinase A regulatory subunit binding [GO:0034237]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrion [GO:0005739]; fatty-acyl-CoA binding [GO:0000062]; protein kinase A regulatory subunit binding [GO:0034237]; steroid biosynthetic process [GO:0006694]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:30755512, ECO:0000269|PubMed:31381608}; Peripheral membrane protein {ECO:0000305|PubMed:31381608}; Cytoplasmic side {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Also mitochondrial (via its interaction with PBR). {ECO:0000250}.
Q9H3Q1	reviewed	BORG4_HUMAN	Cdc42 effector protein 4 (Binder of Rho GTPases 4)	CDC42EP4 BORG4 CEP4	Homo sapiens (Human)	356	FUNCTION: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.		cellular response to type II interferon [GO:0071346]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; microtubule cytoskeleton [GO:0015630]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	RNA binding [GO:0003723]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; microtubule cytoskeleton [GO:0015630]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; cellular response to type II interferon [GO:0071346]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Q9H3Q3	reviewed	G3ST2_HUMAN	Galactose-3-O-sulfotransferase 2 (Gal3ST-2) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 2) (Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2) (Glycoprotein beta-Gal 3'-sulfotransferase 2)	GAL3ST2 GP3ST	Homo sapiens (Human)	398	FUNCTION: Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.		glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101]	Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]	galactose 3-O-sulfotransferase activity [GO:0050694]; galactosylceramide sulfotransferase activity [GO:0001733]; sulfotransferase activity [GO:0008146]	Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]; galactose 3-O-sulfotransferase activity [GO:0050694]; galactosylceramide sulfotransferase activity [GO:0001733]; sulfotransferase activity [GO:0008146]; glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:11029462}; Single-pass type II membrane protein {ECO:0000305|PubMed:11029462}.
Q9H3R0	reviewed	KDM4C_HUMAN	Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C)	KDM4C GASC1 JHDM3C JMJD2C KIAA0780	Homo sapiens (Human)	1056	FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.		androgen receptor signaling pathway [GO:0030521]; blastocyst formation [GO:0001825]; chromatin remodeling [GO:0006338]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of gene expression [GO:0010468]; regulation of stem cell differentiation [GO:2000736]; stem cell population maintenance [GO:0019827]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	enzyme binding [GO:0019899]; H3K9me3 modified histone binding [GO:0062072]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; enzyme binding [GO:0019899]; H3K9me3 modified histone binding [GO:0062072]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; zinc ion binding [GO:0008270]; androgen receptor signaling pathway [GO:0030521]; blastocyst formation [GO:0001825]; chromatin remodeling [GO:0006338]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of gene expression [GO:0010468]; regulation of stem cell differentiation [GO:2000736]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
Q9H3R1	reviewed	NDST4_HUMAN	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 4) (NDST-4) (N-heparan sulfate sulfotransferase 4) (N-HSST 4) [Includes: Heparan sulfate N-deacetylase 4 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 4 (EC 2.8.2.-)]	NDST4 HSST4	Homo sapiens (Human)	872	FUNCTION: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). {ECO:0000250}.	MISCELLANEOUS: The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences.	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	[heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; N-acetylglucosamine deacetylase activity [GO:0050119]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; N-acetylglucosamine deacetylase activity [GO:0050119]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9H3R2	reviewed	MUC13_HUMAN	Mucin-13 (MUC-13) (Down-regulated in colon cancer 1)	MUC13 DRCC1 RECC UNQ6194/PRO20221	Homo sapiens (Human)	512	FUNCTION: Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.		maintenance of gastrointestinal epithelium [GO:0030277]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	protein homodimerization activity [GO:0042803]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]; maintenance of gastrointestinal epithelium [GO:0030277]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11278439}; Single-pass type I membrane protein {ECO:0000269|PubMed:11278439}. Apical cell membrane {ECO:0000269|PubMed:11278439}. Secreted {ECO:0000269|PubMed:11278439}. Note=Also exists as a soluble form.
Q9H3R5	reviewed	CENPH_HUMAN	Centromere protein H (CENP-H) (Interphase centromere complex protein 35)	CENPH ICEN35	Homo sapiens (Human)	247	FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:14536089, ECO:0000269|PubMed:16875666, ECO:0000269|PubMed:18007590}.		chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; kinetochore organization [GO:0051383]; mitotic spindle organization [GO:0007052]	chromosome [GO:0005694]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	kinetochore binding [GO:0043515]	chromosome [GO:0005694]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; kinetochore binding [GO:0043515]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; kinetochore organization [GO:0051383]; mitotic spindle organization [GO:0007052]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.
Q9H3S1	reviewed	SEM4A_HUMAN	Semaphorin-4A (Semaphorin-B) (Sema B)	SEMA4A SEMAB SEMB UNQ783/PRO1317	Homo sapiens (Human)	761	FUNCTION: Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity). {ECO:0000250|UniProtKB:Q62178}.		angiogenesis [GO:0001525]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of angiogenesis [GO:0016525]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of excitatory synapse assembly [GO:1904891]; positive regulation of inhibitory synapse assembly [GO:1905704]; regulation of cell shape [GO:0008360]; regulation of endothelial cell migration [GO:0010594]; semaphorin-plexin signaling pathway [GO:0071526]; T-helper 1 cell differentiation [GO:0045063]	plasma membrane [GO:0005886]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	plasma membrane [GO:0005886]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; angiogenesis [GO:0001525]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of angiogenesis [GO:0016525]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of excitatory synapse assembly [GO:1904891]; positive regulation of inhibitory synapse assembly [GO:1905704]; regulation of cell shape [GO:0008360]; regulation of endothelial cell migration [GO:0010594]; semaphorin-plexin signaling pathway [GO:0071526]; T-helper 1 cell differentiation [GO:0045063]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22956603}; Single-pass type I membrane protein {ECO:0000255}.
Q9H3S3	reviewed	TMPS5_HUMAN	Transmembrane protease serine 5 (EC 3.4.21.-) (Spinesin)	TMPRSS5	Homo sapiens (Human)	457	FUNCTION: May play a role in hearing. {ECO:0000269|PubMed:17918732}.		proteolysis [GO:0006508]	neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9H3S4	reviewed	TPK1_HUMAN	Thiamin pyrophosphokinase 1 (hTPK1) (EC 2.7.6.2) (Placental protein 20) (PP20) (Thiamine pyrophosphokinase 1)	TPK1	Homo sapiens (Human)	243	FUNCTION: Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. {ECO:0000269|PubMed:11342111}.		phosphorylation [GO:0016310]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine metabolic process [GO:0006772]	cytosol [GO:0005829]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; thiamine binding [GO:0030975]; thiamine diphosphokinase activity [GO:0004788]	cytosol [GO:0005829]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; thiamine binding [GO:0030975]; thiamine diphosphokinase activity [GO:0004788]; phosphorylation [GO:0016310]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine metabolic process [GO:0006772]	
Q9H3S7	reviewed	PTN23_HUMAN	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)	PTPN23 KIAA1471	Homo sapiens (Human)	1636	FUNCTION: Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}.		cilium assembly [GO:0060271]; dephosphorylation [GO:0016311]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; negative regulation of epithelial cell migration [GO:0010633]; positive regulation of adherens junction organization [GO:1903393]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of homophilic cell adhesion [GO:1903387]; positive regulation of Wnt protein secretion [GO:0061357]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; cilium assembly [GO:0060271]; dephosphorylation [GO:0016311]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; negative regulation of epithelial cell migration [GO:0010633]; positive regulation of adherens junction organization [GO:1903393]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of homophilic cell adhesion [GO:1903387]; positive regulation of Wnt protein secretion [GO:0061357]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.
Q9H3T2	reviewed	SEM6C_HUMAN	Semaphorin-6C (Semaphorin-Y) (Sema Y)	SEMA6C KIAA1869 SEMAY	Homo sapiens (Human)	930	FUNCTION: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. {ECO:0000269|PubMed:12110693}.		axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q9H3T3	reviewed	SEM6B_HUMAN	Semaphorin-6B (Semaphorin-Z) (Sema Z)	SEMA6B SEMAN SEMAZ UNQ1907/PRO4353	Homo sapiens (Human)	888	FUNCTION: Functions as a cell surface repellent for mossy fibers of developping neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}.		axon guidance [GO:0007411]; central nervous system development [GO:0007417]; hippocampus development [GO:0021766]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	plasma membrane [GO:0005886]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	plasma membrane [GO:0005886]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; axon guidance [GO:0007411]; central nervous system development [GO:0007417]; hippocampus development [GO:0021766]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32302524}; Single-pass type I membrane protein {ECO:0000255}.
Q9H3U1	reviewed	UN45A_HUMAN	Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1)	UNC45A SMAP1	Homo sapiens (Human)	944	FUNCTION: Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). {ECO:0000250, ECO:0000269|PubMed:12119110, ECO:0000269|PubMed:16478993, ECO:0000305}.		cell differentiation [GO:0030154]; chaperone-mediated protein folding [GO:0061077]; muscle organ development [GO:0007517]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471]	cadherin binding [GO:0045296]; Hsp90 protein binding [GO:0051879]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471]; cadherin binding [GO:0045296]; Hsp90 protein binding [GO:0051879]; cell differentiation [GO:0030154]; chaperone-mediated protein folding [GO:0061077]; muscle organ development [GO:0007517]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16478993}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16478993}. Nucleus {ECO:0000269|PubMed:16478993}. Note=Predominant in the perinuclear region. Little protein in the nucleus.
Q9H3U5	reviewed	MFSD1_HUMAN	Major facilitator superfamily domain-containing protein 1 (Smooth muscle cell-associated protein 4) (SMAP-4)	MFSD1 SMAP4 UG0581B09	Homo sapiens (Human)	465	FUNCTION: Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP. {ECO:0000250|UniProtKB:Q9DC37}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821]	lysosomal membrane [GO:0005765]; lysosome [GO:0005764]	protein homodimerization activity [GO:0042803]; transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; protein homodimerization activity [GO:0042803]; transmembrane transporter activity [GO:0022857]; protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9DC37}; Multi-pass membrane protein {ECO:0000255}.
Q9H3U7	reviewed	SMOC2_HUMAN	SPARC-related modular calcium-binding protein 2 (Secreted modular calcium-binding protein 2) (SMOC-2) (Smooth muscle-associated protein 2) (SMAP-2)	SMOC2 SMAP2 MSTP117	Homo sapiens (Human)	446	FUNCTION: Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis. {ECO:0000250, ECO:0000269|PubMed:16774925}.		extracellular matrix organization [GO:0030198]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; positive regulation of vascular wound healing [GO:0035470]	basement membrane [GO:0005604]; cell periphery [GO:0071944]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201]	basement membrane [GO:0005604]; cell periphery [GO:0071944]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201]; extracellular matrix organization [GO:0030198]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; positive regulation of vascular wound healing [GO:0035470]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}.
Q9H3Y6	reviewed	SRMS_HUMAN	Tyrosine-protein kinase Srms (EC 2.7.10.2)	SRMS C20orf148	Homo sapiens (Human)	488	FUNCTION: Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). {ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:29496907, ECO:0000269|PubMed:35927303}.		cell differentiation [GO:0030154]; innate immune response [GO:0045087]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of TORC1 signaling [GO:1904263]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; cell differentiation [GO:0030154]; innate immune response [GO:0045087]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of TORC1 signaling [GO:1904263]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:29496907}. Note=Localizes to punctate cytoplasmic structures. {ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:29496907}.
Q9H3Z4	reviewed	DNJC5_HUMAN	DnaJ homolog subfamily C member 5 (Ceroid-lipofuscinosis neuronal protein 4) (Cysteine string protein) (CSP)	DNAJC5 CLN4	Homo sapiens (Human)	198	FUNCTION: Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). {ECO:0000250|UniProtKB:P60904, ECO:0000250|UniProtKB:Q29455}.	MISCELLANEOUS: Upon phosphorylation, Ser-10 interacts with Lys-58, a highly conserved residue in DnaJ proteins that is also a ubiquitination site in DNAJC5. {ECO:0000305|PubMed:27452402}.	chaperone-mediated protein folding [GO:0061077]; exocytosis [GO:0006887]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; regulated exocytosis [GO:0045055]; regulation of synaptic vesicle cycle [GO:0098693]; synaptic vesicle exocytosis [GO:0016079]	azurophil granule membrane [GO:0035577]; chromaffin granule membrane [GO:0042584]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]	ATP-dependent protein binding [GO:0043008]	azurophil granule membrane [GO:0035577]; chromaffin granule membrane [GO:0042584]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]; ATP-dependent protein binding [GO:0043008]; chaperone-mediated protein folding [GO:0061077]; exocytosis [GO:0006887]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; regulated exocytosis [GO:0045055]; regulation of synaptic vesicle cycle [GO:0098693]; synaptic vesicle exocytosis [GO:0016079]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q29455}. Membrane {ECO:0000250|UniProtKB:Q29455}; Lipid-anchor {ECO:0000250|UniProtKB:Q29455}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:Q29455}. Melanosome {ECO:0000269|PubMed:17081065}. Cell membrane {ECO:0000269|PubMed:21820099}. Note=The association with membranes is regulated by palmitoylation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000250|UniProtKB:Q29455, ECO:0000269|PubMed:17081065}.
Q9H400	reviewed	LIME1_HUMAN	Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule)	LIME1 LIME LP8067	Homo sapiens (Human)	295	FUNCTION: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:14610046}.		adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell receptor signaling pathway [GO:0050852]	B cell receptor complex [GO:0019815]; extracellular space [GO:0005615]	protein kinase binding [GO:0019901]	B cell receptor complex [GO:0019815]; extracellular space [GO:0005615]; protein kinase binding [GO:0019901]; adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:14610046}; Single-pass type III membrane protein {ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:14610046}. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.
Q9H410	reviewed	DSN1_HUMAN	Kinetochore-associated protein DSN1 homolog	DSN1 C20orf172 MIS13	Homo sapiens (Human)	356	FUNCTION: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}.		attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; skeletal muscle satellite cell proliferation [GO:0014841]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]		azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; skeletal muscle satellite cell proliferation [GO:0014841]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. Note=Associated with the kinetochore. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}.
Q9H422	reviewed	HIPK3_HUMAN	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1)	HIPK3 DYRK6 FIST3 PKY	Homo sapiens (Human)	1215	FUNCTION: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). {ECO:0000269|PubMed:14766760, ECO:0000269|PubMed:17210646}.		apoptotic process [GO:0006915]; mRNA transcription [GO:0009299]; negative regulation of apoptotic process [GO:0043066]; negative regulation of JUN kinase activity [GO:0043508]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; apoptotic process [GO:0006915]; mRNA transcription [GO:0009299]; negative regulation of apoptotic process [GO:0043066]; negative regulation of JUN kinase activity [GO:0043508]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11034606}. Nucleus {ECO:0000269|PubMed:11034606}.
Q9H427	reviewed	KCNKF_HUMAN	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3) (Two pore K(+) channel KT3.3)	KCNK15 TASK5	Homo sapiens (Human)	330	FUNCTION: Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.		potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]; stabilization of membrane potential [GO:0030322]	plasma membrane [GO:0005886]	outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]; outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9H444	reviewed	CHM4B_HUMAN	Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2)	CHMP4B C20orf178 SHAX1	Homo sapiens (Human)	224	FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:26040712}.; FUNCTION: (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861}.	MISCELLANEOUS: Its overexpression strongly inhibits HIV-1 release.	autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; maintenance of lens transparency [GO:0036438]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nervous system process [GO:0050877]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein polymerization [GO:0051258]; regulation of autophagy [GO:0010506]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding [GO:0046755]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; maintenance of lens transparency [GO:0036438]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nervous system process [GO:0050877]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein polymerization [GO:0051258]; regulation of autophagy [GO:0010506]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding [GO:0046755]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15511219}. Late endosome membrane {ECO:0000269|PubMed:15511219, ECO:0000305|PubMed:12860994}; Peripheral membrane protein {ECO:0000305}. Midbody {ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22422861}. Nucleus envelope {ECO:0000269|PubMed:26040712}. Note=Recruited to the nuclear envelope by CHMP7 during late anaphase (PubMed:26040712). Localizes transiently to the midbody arms immediately before abscission (PubMed:22422861). {ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:26040712}.
Q9H461	reviewed	FZD8_HUMAN	Frizzled-8 (Fz-8) (hFz8)	FZD8	Homo sapiens (Human)	694	FUNCTION: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. {ECO:0000269|PubMed:11448771}.		angiogenesis [GO:0001525]; canonical Wnt signaling pathway [GO:0060070]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of protein phosphorylation [GO:0001934]; T cell differentiation in thymus [GO:0033077]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]	G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; angiogenesis [GO:0001525]; canonical Wnt signaling pathway [GO:0060070]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of protein phosphorylation [GO:0001934]; T cell differentiation in thymus [GO:0033077]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with GOPC at the Golgi apparatus. {ECO:0000250}.
Q9H467	reviewed	CUED2_HUMAN	CUE domain-containing protein 2	CUEDC2 C10orf66 HOYS6	Homo sapiens (Human)	287	FUNCTION: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. {ECO:0000269|PubMed:17347654, ECO:0000269|PubMed:21572428}.		negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of macrophage cytokine production [GO:0010936]	cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]	ubiquitin binding [GO:0043130]	cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; ubiquitin binding [GO:0043130]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of macrophage cytokine production [GO:0010936]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17347654}. Nucleus {ECO:0000269|PubMed:17347654}.
Q9H469	reviewed	FXL15_HUMAN	F-box/LRR-repeat protein 15 (F-box only protein 37)	FBXL15 FBXO37	Homo sapiens (Human)	300	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2. {ECO:0000269|PubMed:21572392}.		bone mineralization [GO:0030282]; dorsal/ventral pattern formation [GO:0009953]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of BMP signaling pathway [GO:0030513]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; bone mineralization [GO:0030282]; dorsal/ventral pattern formation [GO:0009953]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of BMP signaling pathway [GO:0030513]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21572392}.
Q9H477	reviewed	RBSK_HUMAN	Ribokinase (RK) (EC 2.7.1.15)	RBKS RBSK	Homo sapiens (Human)	322	FUNCTION: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. {ECO:0000255|HAMAP-Rule:MF_03215, ECO:0000269|PubMed:17585908}.		D-ribose catabolic process [GO:0019303]; pentose-phosphate shunt [GO:0006098]	cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ribokinase activity [GO:0004747]	cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ribokinase activity [GO:0004747]; D-ribose catabolic process [GO:0019303]; pentose-phosphate shunt [GO:0006098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P25332, ECO:0000255|HAMAP-Rule:MF_03215}. Nucleus {ECO:0000250|UniProtKB:P25332, ECO:0000255|HAMAP-Rule:MF_03215}.
Q9H479	reviewed	FN3K_HUMAN	Fructosamine-3-kinase (EC 2.7.1.171) (Protein-psicosamine 3-kinase FN3K) (Protein-ribulosamine 3-kinase FN3K) (EC 2.7.1.172)	FN3K	Homo sapiens (Human)	309	FUNCTION: Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848). {ECO:0000250|UniProtKB:Q9ER35, ECO:0000269|PubMed:11016445, ECO:0000269|PubMed:11522682, ECO:0000269|PubMed:11975663, ECO:0000269|PubMed:14633848}.		epithelial cell differentiation [GO:0030855]; fructosamine metabolic process [GO:0030389]; fructoselysine metabolic process [GO:0030393]; phosphorylation [GO:0016310]; post-translational protein modification [GO:0043687]; protein deglycation [GO:0036525]	cytosol [GO:0005829]	ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein-fructosamine 3-kinase activity [GO:0102194]; protein-ribulosamine 3-kinase activity [GO:0102193]	cytosol [GO:0005829]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein-fructosamine 3-kinase activity [GO:0102194]; protein-ribulosamine 3-kinase activity [GO:0102193]; epithelial cell differentiation [GO:0030855]; fructosamine metabolic process [GO:0030389]; fructoselysine metabolic process [GO:0030393]; phosphorylation [GO:0016310]; post-translational protein modification [GO:0043687]; protein deglycation [GO:0036525]	
Q9H488	reviewed	OFUT1_HUMAN	GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 1) (O-FucT-1)	POFUT1 FUT12 KIAA0180	Homo sapiens (Human)	388	FUNCTION: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs). {ECO:0000269|PubMed:11524432, ECO:0000269|PubMed:28334865, ECO:0000269|PubMed:8358148}.		angiogenesis [GO:0001525]; fucose metabolic process [GO:0006004]; heart development [GO:0007507]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; O-glycan processing [GO:0016266]; protein O-linked fucosylation [GO:0036066]; protein O-linked glycosylation [GO:0006493]; regulation of DNA-templated transcription [GO:0006355]; regulation of Notch signaling pathway [GO:0008593]; somitogenesis [GO:0001756]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	fucosyltransferase activity [GO:0008417]; peptide-O-fucosyltransferase activity [GO:0046922]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; fucosyltransferase activity [GO:0008417]; peptide-O-fucosyltransferase activity [GO:0046922]; angiogenesis [GO:0001525]; fucose metabolic process [GO:0006004]; heart development [GO:0007507]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; O-glycan processing [GO:0016266]; protein O-linked fucosylation [GO:0036066]; protein O-linked glycosylation [GO:0006493]; regulation of DNA-templated transcription [GO:0006355]; regulation of Notch signaling pathway [GO:0008593]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6EV70}.
Q9H490	reviewed	PIGU_HUMAN	Phosphatidylinositol glycan anchor biosynthesis class U protein (Cell division cycle protein 91-like 1) (Protein CDC91-like 1) (GPI transamidase component PIG-U)	PIGU CDC91L1 PSEC0205 UNQ3055/PRO9875	Homo sapiens (Human)	435	FUNCTION: Component of the GPI transamidase complex, necessary for transfer of GPI to proteins (PubMed:34576938). May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI. {ECO:0000269|PubMed:12802054, ECO:0000269|PubMed:34576938}.		attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]; plasma membrane [GO:0005886]		endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9H492	reviewed	MLP3A_HUMAN	Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (MAP1A/MAP1B light chain 3 A) (MAP1A/MAP1B LC3 A) (Microtubule-associated protein 1 light chain 3 alpha)	MAP1LC3A	Homo sapiens (Human)	121	FUNCTION: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). {ECO:0000269|PubMed:20713600, ECO:0000269|PubMed:24290141, ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}.		autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy of mitochondrion [GO:0000422]; cellular response to amino acid starvation [GO:0034198]; cellular response to copper ion [GO:0071280]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; macroautophagy [GO:0016236]; response to iron(II) ion [GO:0010040]; response to lead ion [GO:0010288]	autolysosome [GO:0044754]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; microtubule [GO:0005874]; organelle membrane [GO:0031090]	microtubule binding [GO:0008017]; phospholipid binding [GO:0005543]; ubiquitin protein ligase binding [GO:0031625]	autolysosome [GO:0044754]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; microtubule [GO:0005874]; organelle membrane [GO:0031090]; microtubule binding [GO:0008017]; phospholipid binding [GO:0005543]; ubiquitin protein ligase binding [GO:0031625]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy of mitochondrion [GO:0000422]; cellular response to amino acid starvation [GO:0034198]; cellular response to copper ion [GO:0071280]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; macroautophagy [GO:0016236]; response to iron(II) ion [GO:0010040]; response to lead ion [GO:0010288]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:12740394, ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:19056683, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:22421968, ECO:0000269|PubMed:23459205}; Lipid-anchor {ECO:0000269|PubMed:15187094}. Endomembrane system {ECO:0000269|PubMed:12740394}; Lipid-anchor {ECO:0000269|PubMed:15187094}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91VR7}. Note=LC3-II binds to the autophagic membranes. {ECO:0000269|PubMed:15187094}.
Q9H497	reviewed	TOR3A_HUMAN	Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A)	TOR3A ADIR	Homo sapiens (Human)	397				endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nuclear envelope [GO:0005635]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nuclear envelope [GO:0005635]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum lumen.
Q9H4A3	reviewed	WNK1_HUMAN	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)	WNK1 HSN2 KDP KIAA0344 PRKWNK1	Homo sapiens (Human)	2382	FUNCTION: Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}.	MISCELLANEOUS: [Isoform 4]: Contains the nervous system-specific exon HSN2. Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Contains the nervous system-specific exon HSN2. Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Contains the nervous system-specific exon HSN2. Produced by alternative splicing. {ECO:0000305}.	cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular response to chemokine [GO:1990869]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; heart development [GO:0007507]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; lymphocyte migration into lymph node [GO:0097022]; monoatomic cation homeostasis [GO:0055080]; monoatomic ion transport [GO:0006811]; negative regulation of autophagy [GO:0010507]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; negative regulation of GTPase activity [GO:0034260]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of sodium ion transport [GO:0010766]; neuron development [GO:0048666]; non-membrane-bounded organelle assembly [GO:0140694]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of termination of RNA polymerase II transcription [GO:1904595]; potassium ion homeostasis [GO:0055075]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; protein phosphorylation [GO:0006468]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of mRNA export from nucleus [GO:0010793]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transport [GO:0002028]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]; T cell receptor signaling pathway [GO:0050852]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; phosphatase binding [GO:0019902]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; phosphatase binding [GO:0019902]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular response to chemokine [GO:1990869]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; heart development [GO:0007507]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; lymphocyte migration into lymph node [GO:0097022]; monoatomic cation homeostasis [GO:0055080]; monoatomic ion transport [GO:0006811]; negative regulation of autophagy [GO:0010507]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; negative regulation of GTPase activity [GO:0034260]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of sodium ion transport [GO:0010766]; neuron development [GO:0048666]; non-membrane-bounded organelle assembly [GO:0140694]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of termination of RNA polymerase II transcription [GO:1904595]; potassium ion homeostasis [GO:0055075]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; protein phosphorylation [GO:0006468]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of mRNA export from nucleus [GO:0010793]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transport [GO:0002028]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:36318922}. Nucleus {ECO:0000269|PubMed:29196535}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:21220314}. Note=Mediates formation and localizes to cytoplasmic membraneless compartment in response to hyperosmotic stress (PubMed:36318922). Also localizes to the nucleus (PubMed:29196535). Localizes to the mitotic spindle during mitosis (PubMed:21220314). {ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:36318922}.
Q9H4A5	reviewed	GLP3L_HUMAN	Golgi phosphoprotein 3-like (GPP34-related protein)	GOLPH3L GPP34R	Homo sapiens (Human)	285	FUNCTION: Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. {ECO:0000269|PubMed:23345592}.		Golgi organization [GO:0007030]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle budding [GO:0048194]; positive regulation of protein secretion [GO:0050714]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	phosphatidylinositol-4-phosphate binding [GO:0070273]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; phosphatidylinositol-4-phosphate binding [GO:0070273]; Golgi organization [GO:0007030]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle budding [GO:0048194]; positive regulation of protein secretion [GO:0050714]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:23345592}; Peripheral membrane protein {ECO:0000269|PubMed:23345592}; Cytoplasmic side {ECO:0000269|PubMed:23345592}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:23345592}; Peripheral membrane protein {ECO:0000269|PubMed:23345592}; Cytoplasmic side {ECO:0000269|PubMed:23345592}. Note=Phosphatidylinositol 4-phosphate (PtdIns4P)-binding mediates recruitment to Golgi membranes.
Q9H4A6	reviewed	GOLP3_HUMAN	Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS)	GOLPH3 GPP34	Homo sapiens (Human)	298	FUNCTION: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763, ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}.	MISCELLANEOUS: Modulates sensitivity to rapamycin. Tumors expressing this protein are more sensitive to rapamycin in vivo.	asymmetric Golgi ribbon formation [GO:0090164]; cell adhesion molecule production [GO:0060352]; cell migration [GO:0016477]; cellular response to rapamycin [GO:0072752]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle budding [GO:0048194]; lamellipodium assembly [GO:0030032]; leukocyte tethering or rolling [GO:0050901]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein secretion [GO:0050714]; positive regulation of TOR signaling [GO:0032008]; protein retention in Golgi apparatus [GO:0045053]; protein secretion [GO:0009306]; regulation of mitochondrion organization [GO:0010821]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	enzyme binding [GO:0019899]; phosphatidylinositol-4-phosphate binding [GO:0070273]	cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; enzyme binding [GO:0019899]; phosphatidylinositol-4-phosphate binding [GO:0070273]; asymmetric Golgi ribbon formation [GO:0090164]; cell adhesion molecule production [GO:0060352]; cell migration [GO:0016477]; cellular response to rapamycin [GO:0072752]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle budding [GO:0048194]; lamellipodium assembly [GO:0030032]; leukocyte tethering or rolling [GO:0050901]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein secretion [GO:0050714]; positive regulation of TOR signaling [GO:0032008]; protein retention in Golgi apparatus [GO:0045053]; protein secretion [GO:0009306]; regulation of mitochondrion organization [GO:0010821]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space. Cell membrane {ECO:0000250}. Endosome {ECO:0000250}. Note=Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes. {ECO:0000305}.
Q9H4A9	reviewed	DPEP2_HUMAN	Dipeptidase 2 (EC 3.4.13.19)	DPEP2 UNQ284/PRO323	Homo sapiens (Human)	486	FUNCTION: Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:32325220). Hydrolyzes cystinyl-bis-glycine (PubMed:32325220). {ECO:0000269|PubMed:32325220}.; FUNCTION: Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappaB inflammatory signaling pathway. {ECO:0000250|UniProtKB:Q8C255}.		leukotriene D4 catabolic process [GO:1901749]; leukotriene metabolic process [GO:0006691]; proteolysis [GO:0006508]	membrane [GO:0016020]; side of membrane [GO:0098552]	dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]	membrane [GO:0016020]; side of membrane [GO:0098552]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]; leukotriene D4 catabolic process [GO:1901749]; leukotriene metabolic process [GO:0006691]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8C255}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q8C255}.
Q9H4B0	reviewed	OSGL1_HUMAN	tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase-like protein 1) (OSGEP-like protein 1) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1)	OSGEPL1 GCP1	Homo sapiens (Human)	414	FUNCTION: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. {ECO:0000255|HAMAP-Rule:MF_03179, ECO:0000269|PubMed:29760464, ECO:0000269|PubMed:32047918}.		tRNA threonylcarbamoyladenosine modification [GO:0002949]	mitochondrion [GO:0005739]	metal ion binding [GO:0046872]; N(6)-L-threonylcarbamoyladenine synthase activity [GO:0061711]	mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; N(6)-L-threonylcarbamoyladenine synthase activity [GO:0061711]; tRNA threonylcarbamoyladenosine modification [GO:0002949]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03179, ECO:0000269|PubMed:19694617, ECO:0000269|PubMed:29760464}.
Q9H4B4	reviewed	PLK3_HUMAN	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase)	PLK3 CNK FNK PRK	Homo sapiens (Human)	646	FUNCTION: Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. {ECO:0000269|PubMed:10557092, ECO:0000269|PubMed:11156373, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:11971976, ECO:0000269|PubMed:12242661, ECO:0000269|PubMed:14968113, ECO:0000269|PubMed:14980500, ECO:0000269|PubMed:15021912, ECO:0000269|PubMed:16478733, ECO:0000269|PubMed:16481012, ECO:0000269|PubMed:17264206, ECO:0000269|PubMed:17804415, ECO:0000269|PubMed:18062778, ECO:0000269|PubMed:18650425, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:19490146, ECO:0000269|PubMed:20889502, ECO:0000269|PubMed:20940307, ECO:0000269|PubMed:20951827, ECO:0000269|PubMed:21098032, ECO:0000269|PubMed:21264284, ECO:0000269|PubMed:21376736, ECO:0000269|PubMed:21840391, ECO:0000269|PubMed:9353331}.		apoptotic process [GO:0006915]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endomitotic cell cycle [GO:0007113]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; Golgi disassembly [GO:0090166]; mitotic G1/S transition checkpoint signaling [GO:0044819]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of chaperone-mediated autophagy [GO:1904716]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [GO:2000777]; protein phosphorylation [GO:0006468]; regulation of cell division [GO:0051302]; regulation of cytokinesis [GO:0032465]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to osmotic stress [GO:0006970]; response to radiation [GO:0009314]; response to reactive oxygen species [GO:0000302]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi stack [GO:0005795]; kinetochore [GO:0000776]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi stack [GO:0005795]; kinetochore [GO:0000776]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endomitotic cell cycle [GO:0007113]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; Golgi disassembly [GO:0090166]; mitotic G1/S transition checkpoint signaling [GO:0044819]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of chaperone-mediated autophagy [GO:1904716]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [GO:2000777]; protein phosphorylation [GO:0006468]; regulation of cell division [GO:0051302]; regulation of cytokinesis [GO:0032465]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to osmotic stress [GO:0006970]; response to radiation [GO:0009314]; response to reactive oxygen species [GO:0000302]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleolus. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase. According to a report, PLK3 localizes only in the nucleolus and not in the centrosome, or in any other location in the cytoplasm (PubMed:17264206). The discrepancies in results may be explained by the PLK3 antibody specificity, by cell line-specific expression or post-translational modifications. {ECO:0000269|PubMed:17264206}.
Q9H4B6	reviewed	SAV1_HUMAN	Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45)	SAV1 WW45	Homo sapiens (Human)	383	FUNCTION: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395}.		cardiac muscle cell proliferation [GO:0060038]; epithelial cell proliferation [GO:0050673]; hair follicle development [GO:0001942]; hippo signaling [GO:0035329]; intestinal epithelial cell differentiation [GO:0060575]; keratinocyte apoptotic process [GO:0097283]; keratinocyte differentiation [GO:0030216]; lung epithelial cell differentiation [GO:0060487]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of keratinocyte apoptotic process [GO:1902174]; protein stabilization [GO:0050821]; regulation of stem cell population maintenance [GO:2000036]; ventricular septum morphogenesis [GO:0060412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; cardiac muscle cell proliferation [GO:0060038]; epithelial cell proliferation [GO:0050673]; hair follicle development [GO:0001942]; hippo signaling [GO:0035329]; intestinal epithelial cell differentiation [GO:0060575]; keratinocyte apoptotic process [GO:0097283]; keratinocyte differentiation [GO:0030216]; lung epithelial cell differentiation [GO:0060487]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of keratinocyte apoptotic process [GO:1902174]; protein stabilization [GO:0050821]; regulation of stem cell population maintenance [GO:2000036]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19212654}. Cytoplasm {ECO:0000269|PubMed:19212654}.
Q9H4B7	reviewed	TBB1_HUMAN	Tubulin beta-1 chain	TUBB1	Homo sapiens (Human)	451	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.		microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; mitotic cell cycle [GO:0000278]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; spindle assembly [GO:0051225]; thyroid gland development [GO:0030878]; thyroid hormone transport [GO:0070327]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; mitotic cell cycle [GO:0000278]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; spindle assembly [GO:0051225]; thyroid gland development [GO:0030878]; thyroid hormone transport [GO:0070327]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18849486}.
Q9H4D0	reviewed	CSTN2_HUMAN	Calsyntenin-2 (Alcadein-gamma) (Alc-gamma)	CLSTN2 CS2	Homo sapiens (Human)	955	FUNCTION: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). {ECO:0000250|UniProtKB:Q99JH7, ECO:0000250|UniProtKB:Q9ER65}.		associative learning [GO:0008306]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inhibitory synapse assembly [GO:1904862]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]	cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]	amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; kinesin binding [GO:0019894]; X11-like protein binding [GO:0042988]	cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; kinesin binding [GO:0019894]; X11-like protein binding [GO:0042988]; associative learning [GO:0008306]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inhibitory synapse assembly [GO:1904862]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9ER65}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. {ECO:0000250|UniProtKB:Q9ER65}.
Q9H4D5	reviewed	NXF3_HUMAN	Nuclear RNA export factor 3 (TAP-like protein 3) (TAPL-3)	NXF3 TAPL3	Homo sapiens (Human)	531	FUNCTION: May function as a tissue-specific nuclear mRNA export factor.		mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]	cytoplasm [GO:0005737]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Q9H4E5	reviewed	RHOJ_HUMAN	Rho-related GTP-binding protein RhoJ (Ras-like protein family member 7B) (Tc10-like GTP-binding protein)	RHOJ ARHJ RASL7B RHOI TCL	Homo sapiens (Human)	214	FUNCTION: Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707). {ECO:0000269|PubMed:21628409, ECO:0000269|PubMed:24434213, ECO:0000269|PubMed:30158707}.	MISCELLANEOUS: [Isoform 2]: Could be created by usage of an unusual splicing donor site. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; angiogenesis [GO:0001525]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; regulation of cell shape [GO:0008360]; regulation of endothelial cell migration [GO:0010594]; regulation of sprouting angiogenesis [GO:1903670]; retina vasculature morphogenesis in camera-type eye [GO:0061299]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; angiogenesis [GO:0001525]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; regulation of cell shape [GO:0008360]; regulation of endothelial cell migration [GO:0010594]; regulation of sprouting angiogenesis [GO:1903670]; retina vasculature morphogenesis in camera-type eye [GO:0061299]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27660391, ECO:0000269|PubMed:30158707}; Lipid-anchor {ECO:0000269|PubMed:30158707}; Cytoplasmic side {ECO:0000305}. Note=Localization to the plasma membrane is regulated by GLUL. {ECO:0000269|PubMed:30158707}.
Q9H4E7	reviewed	DEFI6_HUMAN	Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein)	DEF6 IBP	Homo sapiens (Human)	631	FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}.		regulation of small GTPase mediated signal transduction [GO:0051056]; vesicle-mediated transport to the plasma membrane [GO:0098876]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of small GTPase mediated signal transduction [GO:0051056]; vesicle-mediated transport to the plasma membrane [GO:0098876]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15023524}. Cell membrane {ECO:0000269|PubMed:15023524, ECO:0000305|PubMed:12651066}. Nucleus {ECO:0000269|PubMed:15023524}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15023524}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15023524}. Cell projection, filopodium {ECO:0000269|PubMed:15023524}. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate (PubMed:15023524). Binds to actin filaments (PubMed:15023524). {ECO:0000269|PubMed:15023524}.
Q9H4F1	reviewed	SIA7D_HUMAN	Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase (EC 2.4.3.7) (NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase) (ST6GalNAc IV) (ST6GalNAcIV) (Sialyltransferase 3C) (SIAT3-C) (Sialyltransferase 7D) (SIAT7-D)	ST6GALNAC4 SIAT3C SIAT7D	Homo sapiens (Human)	302	FUNCTION: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. Prefers O-glycans to glycoproteins or glycolipids. {ECO:0000250|UniProtKB:Q9R2B6}.		ganglioside biosynthetic process [GO:0001574]; glycolipid metabolic process [GO:0006664]; O-glycan processing [GO:0016266]; oligosaccharide metabolic process [GO:0009311]; viral protein processing [GO:0019082]	Golgi membrane [GO:0000139]	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity [GO:0047290]; sialyltransferase activity [GO:0008373]	Golgi membrane [GO:0000139]; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity [GO:0047290]; sialyltransferase activity [GO:0008373]; ganglioside biosynthetic process [GO:0001574]; glycolipid metabolic process [GO:0006664]; O-glycan processing [GO:0016266]; oligosaccharide metabolic process [GO:0009311]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9H4F8	reviewed	SMOC1_HUMAN	SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1)	SMOC1	Homo sapiens (Human)	434	FUNCTION: Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation. {ECO:0000269|PubMed:20359165, ECO:0000269|PubMed:21194678, ECO:0000269|PubMed:21194680}.		cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; limb development [GO:0060173]; regulation of osteoblast differentiation [GO:0045667]	basement membrane [GO:0005604]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201]	basement membrane [GO:0005604]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; limb development [GO:0060173]; regulation of osteoblast differentiation [GO:0045667]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:12130637, ECO:0000269|PubMed:20359165}. Note=In or around the basement membrane.
Q9H4G0	reviewed	E41L1_HUMAN	Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N)	EPB41L1 KIAA0338	Homo sapiens (Human)	881	FUNCTION: May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.		actomyosin structure organization [GO:0031032]; cortical actin cytoskeleton organization [GO:0030866]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; structural molecule activity [GO:0005198]; actomyosin structure organization [GO:0031032]; cortical actin cytoskeleton organization [GO:0030866]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
Q9H4G4	reviewed	GAPR1_HUMAN	Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2)	GLIPR2 C9orf19 GAPR1	Homo sapiens (Human)	154			positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]	protein homodimerization activity [GO:0042803]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; protein homodimerization activity [GO:0042803]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11865038}; Lipid-anchor {ECO:0000269|PubMed:11865038}. Note=Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate.
Q9H4H8	reviewed	FA83D_HUMAN	Protein FAM83D (Spindle protein CHICA)	FAM83D C20orf129	Homo sapiens (Human)	585	FUNCTION: Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706). {ECO:0000269|PubMed:18485706, ECO:0000269|PubMed:24344117, ECO:0000269|PubMed:25646692}.	MISCELLANEOUS: Was named CHICA (girl in Spanish) because it interacts with KID.	cell division [GO:0051301]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; epithelial to mesenchymal transition [GO:0001837]; metaphase chromosome alignment [GO:0051310]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; protein localization to mitotic spindle [GO:1902480]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein catabolic process [GO:0042176]; regulation of TOR signaling [GO:0032006]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; spindle [GO:0005819]	kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; spindle [GO:0005819]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; cell division [GO:0051301]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; epithelial to mesenchymal transition [GO:0001837]; metaphase chromosome alignment [GO:0051310]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; protein localization to mitotic spindle [GO:1902480]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein catabolic process [GO:0042176]; regulation of TOR signaling [GO:0032006]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:15561729, ECO:0000269|PubMed:18485706}. Note=Primarily cytoplasmic during interphase, but at prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase. {ECO:0000269|PubMed:18485706}.
Q9H4I2	reviewed	ZHX3_HUMAN	Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3)	ZHX3 KIAA0395 TIX1	Homo sapiens (Human)	956	FUNCTION: Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}.		cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12659632}.
Q9H4I9	reviewed	EMRE_HUMAN	Essential MCU regulator, mitochondrial (Single-pass membrane protein with aspartate-rich tail 1, mitochondrial)	SMDT1 C22orf32 EMRE	Homo sapiens (Human)	107	FUNCTION: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988). Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU (PubMed:24231807). Plays a central role in regulating the uniplex complex response to intracellular calcium signaling (PubMed:27099988). Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (PubMed:27099988). {ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:26774479, ECO:0000269|PubMed:27099988}.		calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; uniplex complex [GO:1990246]		mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; uniplex complex [GO:1990246]; calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:26774479, ECO:0000269|PubMed:27099988, ECO:0000269|PubMed:27642048}; Single-pass membrane protein {ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:27099988}. Note=MAIP1 is required to assist sorting of EMRE/SMDT1 into mitochondrion by protecting EMRE/SMDT1 against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) (PubMed:27642048). {ECO:0000269|PubMed:27642048}.
Q9H4K7	reviewed	MTG2_HUMAN	Mitochondrial ribosome-associated GTPase 2 (GTP-binding protein 5) (Protein obg homolog 1) (ObgH1)	MTG2 GTPBP5 OBGH1	Homo sapiens (Human)	406	FUNCTION: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process. {ECO:0000269|PubMed:17054726, ECO:0000269|PubMed:23396448}.		regulation of mitochondrial translation [GO:0070129]; regulation of respiratory system process [GO:0044065]; ribosome biogenesis [GO:0042254]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; regulation of mitochondrial translation [GO:0070129]; regulation of respiratory system process [GO:0044065]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Q9H4L4	reviewed	SENP3_HUMAN	Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3)	SENP3 SSP3 SUSP3	Homo sapiens (Human)	574	FUNCTION: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608}.		negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein desumoylation [GO:0016926]	cytoplasm [GO:0005737]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; deSUMOylase activity [GO:0016929]	cytoplasm [GO:0005737]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; deSUMOylase activity [GO:0016929]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein desumoylation [GO:0016926]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:19680224}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224}. Cytoplasm {ECO:0000250|UniProtKB:Q9EP97}. Note=Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). {ECO:0000250|UniProtKB:Q9EP97, ECO:0000269|PubMed:19680224}.
Q9H4L5	reviewed	OSBL3_HUMAN	Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3)	OSBPL3 KIAA0704 ORP3 OSBP3	Homo sapiens (Human)	887	FUNCTION: Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}.	MISCELLANEOUS: [Isoform 2a]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2b]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2c]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2d]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	bile acid biosynthetic process [GO:0006699]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; filopodium tip [GO:0032433]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; sterol transporter activity [GO:0015248]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; filopodium tip [GO:0032433]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; sterol transporter activity [GO:0015248]; bile acid biosynthetic process [GO:0006699]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16143324}; Peripheral membrane protein {ECO:0000269|PubMed:16143324}. Cytoplasm, cytosol {ECO:0000269|PubMed:16143324}. Cell membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}; Peripheral membrane protein {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. Cell projection, filopodium tip {ECO:0000269|PubMed:18270267}. Nucleus membrane {ECO:0000269|PubMed:16143324}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with OSBPL6 at contact sites between the plasma membrane and the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q9DBS9}.
Q9H4L7	reviewed	SMRCD_HUMAN	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1)	SMARCAD1 KIAA1122	Homo sapiens (Human)	1026	FUNCTION: DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}.	MISCELLANEOUS: [Isoform 3]: Skin-specific. {ECO:0000305}.	chromatin remodeling [GO:0006338]; chromosome separation [GO:0051304]; DNA double-strand break processing [GO:0000729]; regulation of DNA recombination [GO:0000018]	heterochromatin [GO:0000792]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; ubiquitin binding [GO:0043130]	heterochromatin [GO:0000792]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; ubiquitin binding [GO:0043130]; chromatin remodeling [GO:0006338]; chromosome separation [GO:0051304]; DNA double-strand break processing [GO:0000729]; regulation of DNA recombination [GO:0000018]	SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double-strand breaks (DSBs) sites of DNA damage.
Q9H4M3	reviewed	FBX44_HUMAN	F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3)	FBXO44 FBG3 FBX30 FBX44 FBX6A FBXO6A	Homo sapiens (Human)	255	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	MISCELLANEOUS: In contrast to other FBA domain containing proteins, FBXO44 demonstrates no significant binding to any of the 200 glycans tested.	glycoprotein catabolic process [GO:0006516]; proteasomal protein catabolic process [GO:0010498]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; glycoprotein catabolic process [GO:0006516]; proteasomal protein catabolic process [GO:0010498]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]	
Q9H4M7	reviewed	PKHA4_HUMAN	Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)	PLEKHA4 PEPP1	Homo sapiens (Human)	779	FUNCTION: Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}.		positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]	cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Q9H4M9	reviewed	EHD1_HUMAN	EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)	EHD1 PAST PAST1 CDABP0131	Homo sapiens (Human)	534	FUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250). {ECO:0000250|UniProtKB:Q641Z6, ECO:0000250|UniProtKB:Q9WVK4, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250}.		cellular response to nerve growth factor stimulus [GO:1990090]; cholesterol homeostasis [GO:0042632]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; low-density lipoprotein particle clearance [GO:0034383]; neuron projection development [GO:0031175]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of neuron projection development [GO:0010976]; protein homooligomerization [GO:0051260]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]	ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; recycling endosome membrane [GO:0055038]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]	ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; recycling endosome membrane [GO:0055038]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; cellular response to nerve growth factor stimulus [GO:1990090]; cholesterol homeostasis [GO:0042632]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; low-density lipoprotein particle clearance [GO:0034383]; neuron projection development [GO:0031175]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of neuron projection development [GO:0010976]; protein homooligomerization [GO:0051260]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:23596323}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:15020713}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q9WVK4}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, cilium membrane {ECO:0000269|PubMed:25686250}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Preferentially associates with tubular recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:19864458, PubMed:23596323). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity). Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (By similarity). {ECO:0000250|UniProtKB:Q9WVK4, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:25686250}.
Q9H4P4	reviewed	RNF41_HUMAN	E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)	RNF41 FLRF NRDP1 SBBI03	Homo sapiens (Human)	317	FUNCTION: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970). {ECO:0000250, ECO:0000250|UniProtKB:Q8BH75, ECO:0000269|PubMed:12411582, ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15632191, ECO:0000269|PubMed:17210635, ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:19483718, ECO:0000269|PubMed:24949970}.		autophagy [GO:0006914]; extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitophagy [GO:1901525]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of lymphocyte differentiation [GO:0045619]; regulation of MAPK cascade [GO:0043408]; regulation of myeloid cell differentiation [GO:0045637]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of reactive oxygen species metabolic process [GO:2000377]	cytosol [GO:0005829]; endoplasmic reticulum tubular network [GO:0071782]; perinuclear region of cytoplasm [GO:0048471]	erythropoietin receptor binding [GO:0005128]; identical protein binding [GO:0042802]; interleukin-3 receptor binding [GO:0005135]; protein domain specific binding [GO:0019904]; receptor tyrosine kinase binding [GO:0030971]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; endoplasmic reticulum tubular network [GO:0071782]; perinuclear region of cytoplasm [GO:0048471]; erythropoietin receptor binding [GO:0005128]; identical protein binding [GO:0042802]; interleukin-3 receptor binding [GO:0005135]; protein domain specific binding [GO:0019904]; receptor tyrosine kinase binding [GO:0030971]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; autophagy [GO:0006914]; extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitophagy [GO:1901525]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of lymphocyte differentiation [GO:0045619]; regulation of MAPK cascade [GO:0043408]; regulation of myeloid cell differentiation [GO:0045637]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; regulation of reactive oxygen species metabolic process [GO:2000377]	
Q9H4Q3	reviewed	PRD13_HUMAN	PR domain zinc finger protein 13 (EC 2.1.1.-) (PR domain-containing protein 13)	PRDM13 PFM10	Homo sapiens (Human)	707	FUNCTION: May be involved in transcriptional regulation. Is required for the differentiation of KISS1-expressing neurons in the arcuate (Arc) nucleus of the hypothalamus. Is a critical regulator of GABAergic cell fate in the cerebellum, required for normal postnatal cerebellar development (By similarity). {ECO:0000250|UniProtKB:E9PZZ1}.		GABAergic neuron differentiation [GO:0097154]; hypothalamus cell differentiation [GO:0021979]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gene expression [GO:0010468]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; GABAergic neuron differentiation [GO:0097154]; hypothalamus cell differentiation [GO:0021979]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H4Q4	reviewed	PRD12_HUMAN	PR domain zinc finger protein 12 (EC 2.1.1.-) (PR domain-containing protein 12)	PRDM12 PFM9	Homo sapiens (Human)	367	FUNCTION: Involved in the positive regulation of histone H3-K9 dimethylation. {ECO:0000269|PubMed:26005867}.		detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; neuron projection development [GO:0031175]; positive regulation of histone H3-K9 dimethylation [GO:1900111]; protein methylation [GO:0006479]; regulation of gene expression [GO:0010468]; sensory perception of pain [GO:0019233]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone chaperone activity [GO:0140713]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone chaperone activity [GO:0140713]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; neuron projection development [GO:0031175]; positive regulation of histone H3-K9 dimethylation [GO:1900111]; protein methylation [GO:0006479]; regulation of gene expression [GO:0010468]; sensory perception of pain [GO:0019233]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26005867}.
Q9H4S2	reviewed	GSX1_HUMAN	GS homeobox 1 (Homeobox protein GSH-1)	GSX1 GSH1	Homo sapiens (Human)	264	FUNCTION: Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.		adenohypophysis development [GO:0021984]; central nervous system development [GO:0007417]; hypothalamus development [GO:0021854]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spinal cord association neuron differentiation [GO:0021527]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; adenohypophysis development [GO:0021984]; central nervous system development [GO:0007417]; hypothalamus development [GO:0021854]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spinal cord association neuron differentiation [GO:0021527]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q9H4T2	reviewed	ZSC16_HUMAN	Zinc finger and SCAN domain-containing protein 16 (Zinc finger protein 392) (Zinc finger protein 435)	ZSCAN16 ZNF392 ZNF435	Homo sapiens (Human)	348	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H4W6	reviewed	COE3_HUMAN	Transcription factor COE3 (Early B-cell factor 3) (EBF-3) (Olf-1/EBF-like 2) (O/E-2) (OE-2)	EBF3 COE3	Homo sapiens (Human)	596	FUNCTION: Transcriptional activator (PubMed:28017373, PubMed:28017372, PubMed:28017370). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). {ECO:0000250|UniProtKB:Q07802, ECO:0000269|PubMed:28017370, ECO:0000269|PubMed:28017372, ECO:0000269|PubMed:28017373}.		positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28017373}.
Q9H4X1	reviewed	RGCC_HUMAN	Regulator of cell cycle RGCC (Response gene to complement 32 protein) (RGC-32)	RGCC C13orf15 RGC32	Homo sapiens (Human)	137	FUNCTION: Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269|PubMed:11687586, ECO:0000269|PubMed:17146433, ECO:0000269|PubMed:19158077, ECO:0000269|PubMed:22163048}.		cell cycle [GO:0007049]; cellular response to hypoxia [GO:0071456]; complement activation [GO:0006956]; fibroblast activation [GO:0072537]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cytokine production [GO:0001818]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of exit from mitosis [GO:0001100]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; cell cycle [GO:0007049]; cellular response to hypoxia [GO:0071456]; complement activation [GO:0006956]; fibroblast activation [GO:0072537]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cytokine production [GO:0001818]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of exit from mitosis [GO:0001100]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.
Q9H4Y5	reviewed	GSTO2_HUMAN	Glutathione S-transferase omega-2 (GSTO-2) (EC 2.5.1.18) (Glutathione S-transferase omega 2-2) (GSTO 2-2) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2)	GSTO2	Homo sapiens (Human)	243	FUNCTION: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). {ECO:0000269|PubMed:15970797}.		cellular response to arsenic-containing substance [GO:0071243]; glutathione metabolic process [GO:0006749]; L-ascorbic acid metabolic process [GO:0019852]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	glutathione dehydrogenase (ascorbate) activity [GO:0045174]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; methylarsonate reductase activity [GO:0050610]; oxidoreductase activity [GO:0016491]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutathione dehydrogenase (ascorbate) activity [GO:0045174]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; methylarsonate reductase activity [GO:0050610]; oxidoreductase activity [GO:0016491]; cellular response to arsenic-containing substance [GO:0071243]; glutathione metabolic process [GO:0006749]; L-ascorbic acid metabolic process [GO:0019852]; xenobiotic metabolic process [GO:0006805]	
Q9H4Z2	reviewed	ZN335_HUMAN	Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1)	ZNF335	Homo sapiens (Human)	1342	FUNCTION: Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}.		brain development [GO:0007420]; brain morphogenesis [GO:0048854]; cerebral cortex neuron differentiation [GO:0021895]; epigenetic regulation of gene expression [GO:0040029]; in utero embryonic development [GO:0001701]; neuron projection morphogenesis [GO:0048812]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription by RNA polymerase II [GO:0045944]	histone methyltransferase complex [GO:0035097]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	histone methyltransferase complex [GO:0035097]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; brain development [GO:0007420]; brain morphogenesis [GO:0048854]; cerebral cortex neuron differentiation [GO:0021895]; epigenetic regulation of gene expression [GO:0040029]; in utero embryonic development [GO:0001701]; neuron projection morphogenesis [GO:0048812]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12215545}.
Q9H4Z3	reviewed	CAPAM_HUMAN	mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121)	PCIF1 C20orf67 CAPAM PPP1R121	Homo sapiens (Human)	704	FUNCTION: Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178). {ECO:0000269|PubMed:30467178, ECO:0000269|PubMed:30487554, ECO:0000269|PubMed:31279658, ECO:0000269|PubMed:31279659, ECO:0000269|PubMed:33428944}.		mRNA methylation [GO:0080009]; negative regulation of translation [GO:0017148]; positive regulation of translation [GO:0045727]	intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity [GO:0016422]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; S-adenosyl-L-methionine binding [GO:1904047]	intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity [GO:0016422]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; S-adenosyl-L-methionine binding [GO:1904047]; mRNA methylation [GO:0080009]; negative regulation of translation [GO:0017148]; positive regulation of translation [GO:0045727]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12565871, ECO:0000269|PubMed:18294453, ECO:0000269|PubMed:31279659}.
Q9H503	reviewed	BAFL_HUMAN	Barrier-to-autointegration factor-like protein (BAF-L) (Barrier-to-autointegration factor 2)	BANF2 BAFL C20orf179	Homo sapiens (Human)	90	FUNCTION: May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.			cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
Q9H553	reviewed	ALG2_HUMAN	Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (Asparagine-linked glycosylation protein 2 homolog) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase)	ALG2 UNQ666/PRO1298	Homo sapiens (Human)	416	FUNCTION: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. {ECO:0000269|PubMed:12684507}.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein glycosylation [GO:0006486]; response to calcium ion [GO:0051592]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	alpha-1,3-mannosyltransferase activity [GO:0000033]; calcium-dependent protein binding [GO:0048306]; GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0004378]; GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity [GO:0102704]; protein heterodimerization activity [GO:0046982]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; alpha-1,3-mannosyltransferase activity [GO:0000033]; calcium-dependent protein binding [GO:0048306]; GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0004378]; GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity [GO:0102704]; protein heterodimerization activity [GO:0046982]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein glycosylation [GO:0006486]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9H582	reviewed	ZN644_HUMAN	Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2)	ZNF644 KIAA1221 ZEP2	Homo sapiens (Human)	1327	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q9H583	reviewed	HEAT1_HUMAN	HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed]	HEATR1 BAP28 UTP10	Homo sapiens (Human)	2144	FUNCTION: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}.		maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274]	90S preribosome [GO:0030686]; fibrillar center [GO:0001650]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455]	RNA binding [GO:0003723]; snoRNA binding [GO:0030515]	90S preribosome [GO:0030686]; fibrillar center [GO:0001650]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}.
Q9H596	reviewed	DUS21_HUMAN	Dual specificity protein phosphatase 21 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 21) (LMW-DSP21)	DUSP21 LMWDSP21	Homo sapiens (Human)	190	FUNCTION: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.		peptidyl-tyrosine dephosphorylation [GO:0035335]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]	MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; protein tyrosine phosphatase activity [GO:0004725]; peptidyl-tyrosine dephosphorylation [GO:0035335]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12408986}. Nucleus {ECO:0000269|PubMed:12408986}. Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Q9H598	reviewed	VIAAT_HUMAN	Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (hVIAAT)	SLC32A1 VGAT VIAAT	Homo sapiens (Human)	525	FUNCTION: Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity). {ECO:0000250|UniProtKB:O35458, ECO:0000250|UniProtKB:O35633}.		beta-alanine transport [GO:0001762]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid transport [GO:0015812]; glycine transport [GO:0015816]; hippocampus development [GO:0021766]; monoatomic ion transport [GO:0006811]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter secretion [GO:0007269]	cell surface [GO:0009986]; cell tip [GO:0051286]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cone cell pedicle [GO:0044316]; dendrite [GO:0030425]; dendrite terminus [GO:0044292]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:proton antiporter activity [GO:0140800]; gamma-aminobutyric acid:proton symporter activity [GO:0015495]; glycine transmembrane transporter activity [GO:0015187]; glycine:proton antiporter activity [GO:0140799]	cell surface [GO:0009986]; cell tip [GO:0051286]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cone cell pedicle [GO:0044316]; dendrite [GO:0030425]; dendrite terminus [GO:0044292]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:proton antiporter activity [GO:0140800]; gamma-aminobutyric acid:proton symporter activity [GO:0015495]; glycine transmembrane transporter activity [GO:0015187]; glycine:proton antiporter activity [GO:0140799]; beta-alanine transport [GO:0001762]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid transport [GO:0015812]; glycine transport [GO:0015816]; hippocampus development [GO:0021766]; monoatomic ion transport [GO:0006811]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter secretion [GO:0007269]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O35458}; Multi-pass membrane protein {ECO:0000255}. Presynapse {ECO:0000250|UniProtKB:O35633}. Note=Presents in glycine-, GABA- or GABA- and glycine-containing boutons. {ECO:0000250|UniProtKB:O35458}.
Q9H5F2	reviewed	CFA68_HUMAN	Cilia- and flagella-associated protein 68	CFAP68 C11orf1	Homo sapiens (Human)	150	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.			axoneme [GO:0005930]; nucleoplasm [GO:0005654]		axoneme [GO:0005930]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10873569}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q9H5H4	reviewed	ZN768_HUMAN	Zinc finger protein 768	ZNF768	Homo sapiens (Human)	540	FUNCTION: Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}.		regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromosome [GO:0005694]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromosome [GO:0005694]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:30476274}. Chromosome {ECO:0000269|PubMed:30476274}. Note=Localizes to euchromatin. {ECO:0000269|PubMed:30476274}.
Q9H5I1	reviewed	SUV92_HUMAN	Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2)	SUV39H2 KMT1B	Homo sapiens (Human)	410	FUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. {ECO:0000269|PubMed:14765126}.		cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to hypoxia [GO:0071456]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; circadian rhythm [GO:0007623]; epigenetic programming in the zygotic pronuclei [GO:0044725]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]	chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 trimethyltransferase activity [GO:0140949]; S-adenosyl-L-methionine binding [GO:1904047]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 trimethyltransferase activity [GO:0140949]; S-adenosyl-L-methionine binding [GO:1904047]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to hypoxia [GO:0071456]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; circadian rhythm [GO:0007623]; epigenetic programming in the zygotic pronuclei [GO:0044725]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30111536}. Chromosome, centromere {ECO:0000250}. Note=Associates with centromeric constitutive heterochromatin. {ECO:0000250}.
Q9H5I5	reviewed	PIEZ2_HUMAN	Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B)	PIEZO2 C18orf30 C18orf58 FAM38B	Homo sapiens (Human)	2752	FUNCTION: Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. {ECO:0000250|UniProtKB:Q8CD54}.	MISCELLANEOUS: Piezo comes from the Greek 'piesi' meaning pressure.	cellular response to mechanical stimulus [GO:0071260]; detection of mechanical stimulus [GO:0050982]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; monoatomic cation transport [GO:0006812]; regulation of membrane potential [GO:0042391]; response to mechanical stimulus [GO:0009612]	plasma membrane [GO:0005886]	mechanosensitive monoatomic ion channel activity [GO:0008381]; monoatomic cation channel activity [GO:0005261]	plasma membrane [GO:0005886]; mechanosensitive monoatomic ion channel activity [GO:0008381]; monoatomic cation channel activity [GO:0005261]; cellular response to mechanical stimulus [GO:0071260]; detection of mechanical stimulus [GO:0050982]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; monoatomic cation transport [GO:0006812]; regulation of membrane potential [GO:0042391]; response to mechanical stimulus [GO:0009612]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9H5J4	reviewed	ELOV6_HUMAN	Elongation of very long chain fatty acids protein 6 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL6) (ELOVL fatty acid elongase 6) (ELOVL FA elongase 6) (Fatty acid elongase 2) (hELO2) (Fatty acyl-CoA elongase) (Long-chain fatty-acyl elongase) (Very long chain 3-ketoacyl-CoA synthase 6) (Very long chain 3-oxoacyl-CoA synthase 6)	ELOVL6 FACE LCE	Homo sapiens (Human)	265	FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03206, ECO:0000269|PubMed:19575253, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:25003994, ECO:0000269|PubMed:26214738}.		fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cold-induced thermogenesis [GO:0120162]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fatty acid elongase complex [GO:0009923]	fatty acid elongase activity [GO:0009922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fatty acid elongase complex [GO:0009923]; fatty acid elongase activity [GO:0009922]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cold-induced thermogenesis [GO:0120162]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03206, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03206}.
Q9H5J8	reviewed	TAF1D_HUMAN	TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D)	TAF1D JOSD3	Homo sapiens (Human)	278	FUNCTION: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}.		regulation of DNA-templated transcription [GO:0006355]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15520167, ECO:0000269|PubMed:17318177}.
Q9H5K3	reviewed	SG196_HUMAN	Protein O-mannose kinase (POMK) (EC 2.7.1.183) (Protein kinase-like protein SgK196) (Sugen kinase 196)	POMK SGK196	Homo sapiens (Human)	350	FUNCTION: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. {ECO:0000269|PubMed:23519211, ECO:0000269|PubMed:23929950}.		brain development [GO:0007420]; carbohydrate phosphorylation [GO:0046835]; learning or memory [GO:0007611]; neuromuscular process [GO:0050905]; protein O-linked glycosylation [GO:0006493]; sensory perception of pain [GO:0019233]	endoplasmic reticulum membrane [GO:0005789]	ATP binding [GO:0005524]; carbohydrate kinase activity [GO:0019200]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; protein kinase activity [GO:0004672]	endoplasmic reticulum membrane [GO:0005789]; ATP binding [GO:0005524]; carbohydrate kinase activity [GO:0019200]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; protein kinase activity [GO:0004672]; brain development [GO:0007420]; carbohydrate phosphorylation [GO:0046835]; learning or memory [GO:0007611]; neuromuscular process [GO:0050905]; protein O-linked glycosylation [GO:0006493]; sensory perception of pain [GO:0019233]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9H5N1	reviewed	RABE2_HUMAN	Rab GTPase-binding effector protein 2 (Rabaptin-5beta)	RABEP2 RABPT5B	Homo sapiens (Human)	569	FUNCTION: Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062). {ECO:0000269|PubMed:27224062, ECO:0000269|PubMed:29425100, ECO:0000269|PubMed:9524116}.		cell projection organization [GO:0030030]; endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of cilium assembly [GO:1902017]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]	growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096]; cell projection organization [GO:0030030]; endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of cilium assembly [GO:1902017]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29247183, ECO:0000269|PubMed:9524116}. Early endosome {ECO:0000269|PubMed:9524116}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27224062}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27224062}.
Q9H5P4	reviewed	PDZD7_HUMAN	PDZ domain-containing protein 7	PDZD7 PDZK7	Homo sapiens (Human)	1033	FUNCTION: In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1. {ECO:0000250|UniProtKB:E9Q9W7}.		auditory receptor cell development [GO:0060117]; auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; inner ear receptor cell differentiation [GO:0060113]; sensory perception of sound [GO:0007605]	cilium [GO:0005929]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; USH2 complex [GO:1990696]	identical protein binding [GO:0042802]	cilium [GO:0005929]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; USH2 complex [GO:1990696]; identical protein binding [GO:0042802]; auditory receptor cell development [GO:0060117]; auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; inner ear receptor cell differentiation [GO:0060113]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:20440071}. Nucleus {ECO:0000269|PubMed:20440071}. Cell projection, stereocilium {ECO:0000250|UniProtKB:E9Q9W7}. Note=Localizes at the ankle region of the stereocilia. {ECO:0000250|UniProtKB:E9Q9W7}.
Q9H5Q4	reviewed	TFB2M_HUMAN	Dimethyladenosine transferase 2, mitochondrial (EC 2.1.1.-) (Hepatitis C virus NS5A-transactivated protein 5) (HCV NS5A-transactivated protein 5) (Mitochondrial 12S rRNA dimethylase 2) (Mitochondrial transcription factor B2) (h-mtTFB) (h-mtTFB2) (hTFB2M) (mtTFB2) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2)	TFB2M NS5ATP5	Homo sapiens (Human)	396	FUNCTION: S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603, PubMed:12068295, PubMed:20410300, PubMed:15526033). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603, PubMed:15526033). Stimulates transcription independently of the methyltransferase activity (PubMed:12897151). {ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151, ECO:0000269|PubMed:15526033, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:29149603, ECO:0000305|PubMed:12897151, ECO:0000305|PubMed:17031457}.		mitochondrial transcription [GO:0006390]; rRNA methylation [GO:0031167]; transcription initiation at mitochondrial promoter [GO:0006391]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	mitochondrial transcription factor activity [GO:0034246]; RNA binding [GO:0003723]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; mitochondrial transcription factor activity [GO:0034246]; RNA binding [GO:0003723]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]; mitochondrial transcription [GO:0006390]; rRNA methylation [GO:0031167]; transcription initiation at mitochondrial promoter [GO:0006391]	SUBCELLULAR LOCATION: Mitochondrion.
Q9H5U6	reviewed	ZCHC4_HUMAN	rRNA N6-adenosine-methyltransferase ZCCHC4 (EC 2.1.1.-) (Zinc finger CCHC domain-containing protein 4)	ZCCHC4	Homo sapiens (Human)	513	FUNCTION: rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910, PubMed:31328227, PubMed:31799605, PubMed:31695039). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910, PubMed:31799605). {ECO:0000269|PubMed:30531910, ECO:0000269|PubMed:31328227, ECO:0000269|PubMed:31695039, ECO:0000269|PubMed:31799605}.		positive regulation of translation [GO:0045727]; rRNA methylation [GO:0031167]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	nucleic acid binding [GO:0003676]; rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]; S-adenosyl-L-methionine binding [GO:1904047]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleic acid binding [GO:0003676]; rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]; S-adenosyl-L-methionine binding [GO:1904047]; zinc ion binding [GO:0008270]; positive regulation of translation [GO:0045727]; rRNA methylation [GO:0031167]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:30531910, ECO:0000269|PubMed:31799605}. Cytoplasm {ECO:0000269|PubMed:30531910}. Note=Accumulates in the nucleolus, where ribosome biogenesis takes place. {ECO:0000269|PubMed:30531910}.
Q9H5V7	reviewed	IKZF5_HUMAN	Zinc finger protein Pegasus (Ikaros family zinc finger protein 5)	IKZF5 ZNFN1A5	Homo sapiens (Human)	419	FUNCTION: Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (PubMed:10978333, PubMed:31217188). Involved in megakaryocyte differentiation. {ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:31217188}.	MISCELLANEOUS: 'Pegasus' was the winged horse in Greek mythology.	negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]; protein-containing complex [GO:0032991]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31217188}.
Q9H5V8	reviewed	CDCP1_HUMAN	CUB domain-containing protein 1 (Membrane glycoprotein gp140) (Subtractive immunization M plus HEp3-associated 135 kDa protein) (SIMA135) (Transmembrane and associated with src kinases) (CD antigen CD318)	CDCP1 TRASK UNQ2486/PRO5773	Homo sapiens (Human)	836	FUNCTION: May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12799299, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:16404722, ECO:0000269|PubMed:8647901}.			extracellular region [GO:0005576]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Shedding may also lead to a soluble peptide.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Q9H5V9	reviewed	STEEP_HUMAN	STING ER exit protein (STEEP)	STEEP1 CXorf56	Homo sapiens (Human)	222	FUNCTION: Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (PubMed:32690950). Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (PubMed:32690950). {ECO:0000269|PubMed:32690950}.		endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]	cell body [GO:0044297]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cell body [GO:0044297]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29374277, ECO:0000269|PubMed:32690950}. Cytoplasm {ECO:0000269|PubMed:32690950}. Note=Detected in the nucleus and cell soma of various neuronal types. {ECO:0000250|UniProtKB:Q8VDP2}.
Q9H5X1	reviewed	CIA2A_HUMAN	Cytosolic iron-sulfur assembly component 2A (MIP18 family protein FAM96A)	CIAO2A CIA2A FAM96A	Homo sapiens (Human)	160	FUNCTION: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004). As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation (PubMed:23891004). May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 (PubMed:25716227). {ECO:0000250, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:25716227}.		chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]; protein maturation by iron-sulfur cluster transfer [GO:0097428]	CIA complex [GO:0097361]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]	CIA complex [GO:0097361]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]; protein maturation by iron-sulfur cluster transfer [GO:0097428]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22683786}.
Q9H5Y7	reviewed	SLIK6_HUMAN	SLIT and NTRK-like protein 6	SLITRK6	Homo sapiens (Human)	841	FUNCTION: Regulator of neurite outgrowth required for normal hearing and vision. {ECO:0000269|PubMed:23543054}.		adult locomotory behavior [GO:0008344]; auditory behavior [GO:0031223]; auditory receptor cell morphogenesis [GO:0002093]; axonogenesis [GO:0007409]; cochlea development [GO:0090102]; innervation [GO:0060384]; lens development in camera-type eye [GO:0002088]; linear vestibuloocular reflex [GO:0060007]; multicellular organism growth [GO:0035264]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; sensory perception of sound [GO:0007605]; startle response [GO:0001964]; synapse assembly [GO:0007416]; vestibulocochlear nerve development [GO:0021562]; visual perception [GO:0007601]	cell surface [GO:0009986]; plasma membrane [GO:0005886]		cell surface [GO:0009986]; plasma membrane [GO:0005886]; adult locomotory behavior [GO:0008344]; auditory behavior [GO:0031223]; auditory receptor cell morphogenesis [GO:0002093]; axonogenesis [GO:0007409]; cochlea development [GO:0090102]; innervation [GO:0060384]; lens development in camera-type eye [GO:0002088]; linear vestibuloocular reflex [GO:0060007]; multicellular organism growth [GO:0035264]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; sensory perception of sound [GO:0007605]; startle response [GO:0001964]; synapse assembly [GO:0007416]; vestibulocochlear nerve development [GO:0021562]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23543054, ECO:0000269|PubMed:23946138}; Single-pass type I membrane protein {ECO:0000269|PubMed:23543054, ECO:0000269|PubMed:23946138}.
Q9H5Z1	reviewed	DHX35_HUMAN	Probable ATP-dependent RNA helicase DHX35 (EC 3.6.4.13) (DEAH box protein 35)	DHX35 C20orf15 DDX35	Homo sapiens (Human)	703	FUNCTION: May be involved in pre-mRNA splicing.		in utero embryonic development [GO:0001701]; mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; in utero embryonic development [GO:0001701]; mRNA splicing, via spliceosome [GO:0000398]	
Q9H5Z6	reviewed	F124B_HUMAN	Protein FAM124B	FAM124B	Homo sapiens (Human)	455				mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]		mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23285124}.
Q9H611	reviewed	PIF1_HUMAN	ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein)	PIF1 C15orf20	Homo sapiens (Human)	641	FUNCTION: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721, ECO:0000269|PubMed:18835853, ECO:0000269|PubMed:19700773, ECO:0000269|PubMed:20524933, ECO:0000269|PubMed:23657261}.	MISCELLANEOUS: [Isoform 4]: Produced by alternative initiation of isoform 1. {ECO:0000305}.	DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; mitochondrial genome maintenance [GO:0000002]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; regulation of telomere maintenance [GO:0032204]; telomere maintenance via telomerase [GO:0007004]	chromosome, telomeric region [GO:0000781]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; replication fork [GO:0005657]	5'-3' DNA helicase activity [GO:0043139]; 5'-3' DNA/RNA helicase activity [GO:0033678]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; G-quadruplex DNA binding [GO:0051880]; magnesium ion binding [GO:0000287]; single-stranded DNA helicase activity [GO:0017116]; telomerase inhibitor activity [GO:0010521]; telomeric DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; replication fork [GO:0005657]; 5'-3' DNA helicase activity [GO:0043139]; 5'-3' DNA/RNA helicase activity [GO:0033678]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; G-quadruplex DNA binding [GO:0051880]; magnesium ion binding [GO:0000287]; single-stranded DNA helicase activity [GO:0017116]; telomerase inhibitor activity [GO:0010521]; telomeric DNA binding [GO:0042162]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; mitochondrial genome maintenance [GO:0000002]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; regulation of telomere maintenance [GO:0032204]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721}.; SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:23275553}.
Q9H633	reviewed	RPP21_HUMAN	Ribonuclease P protein subunit p21 (RNaseP protein p21) (Ribonuclease P/MRP 21 kDa subunit) (Ribonucleoprotein V)	RPP21 C6orf135 CAT60	Homo sapiens (Human)	154	FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. {ECO:0000269|PubMed:30454648}.		response to xenobiotic stimulus [GO:0009410]; tRNA 5'-leader removal [GO:0001682]; tRNA processing [GO:0008033]	multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]	multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; response to xenobiotic stimulus [GO:0009410]; tRNA 5'-leader removal [GO:0001682]; tRNA processing [GO:0008033]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11497433}.
Q9H649	reviewed	NSUN3_HUMAN	tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 3)	NSUN3 MSTP077 UG0651E06	Homo sapiens (Human)	340	FUNCTION: Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met) (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299, PubMed:27356879). {ECO:0000269|PubMed:27214402, ECO:0000269|PubMed:27356879, ECO:0000269|PubMed:27497299}.		regulation of mitochondrial translation [GO:0070129]; rRNA methylation [GO:0031167]; tRNA wobble base cytosine methylation [GO:0002127]	mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	methyltransferase activity [GO:0008168]; tRNA (cytosine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]	mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; methyltransferase activity [GO:0008168]; tRNA (cytosine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]; regulation of mitochondrial translation [GO:0070129]; rRNA methylation [GO:0031167]; tRNA wobble base cytosine methylation [GO:0002127]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:27214402, ECO:0000269|PubMed:27356879, ECO:0000269|PubMed:27497299}.
Q9H668	reviewed	STN1_HUMAN	CST complex subunit STN1 (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog)	STN1 OBFC1	Homo sapiens (Human)	368	FUNCTION: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22964711, PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres (PubMed:22863775, PubMed:22964711). Promotes general replication start following replication-fork stalling implicating new origin firing (PubMed:22863775). May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (PubMed:23142664). {ECO:0000269|PubMed:19648609, ECO:0000269|PubMed:19854130, ECO:0000269|PubMed:22763445, ECO:0000269|PubMed:22863775, ECO:0000269|PubMed:22964711, ECO:0000269|PubMed:23142664, ECO:0000269|PubMed:25483097, ECO:0000305|PubMed:23851344}.; FUNCTION: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. {ECO:0000269|PubMed:19648609, ECO:0000269|PubMed:19854130}.	MISCELLANEOUS: Cells expressing STN1 mutants defective for dimerization with TEN1 display elongated telomeres and telomere defects associated with telomere uncapping.	negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA replication [GO:0045740]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]	chromosome, telomeric region [GO:0000781]; CST complex [GO:1990879]; fibrillar center [GO:0001650]; intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	single-stranded DNA binding [GO:0003697]; single-stranded telomeric DNA binding [GO:0043047]; telomeric DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; CST complex [GO:1990879]; fibrillar center [GO:0001650]; intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; single-stranded DNA binding [GO:0003697]; single-stranded telomeric DNA binding [GO:0043047]; telomeric DNA binding [GO:0042162]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA replication [GO:0045740]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19854130}. Chromosome, telomere {ECO:0000269|PubMed:19648609, ECO:0000269|PubMed:19854130, ECO:0000269|PubMed:22763445}.
Q9H672	reviewed	ASB7_HUMAN	Ankyrin repeat and SOCS box protein 7 (ASB-7)	ASB7	Homo sapiens (Human)	318	FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250, ECO:0000269|PubMed:16325183}.		intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]		cytosol [GO:0005829]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	
Q9H694	reviewed	BICC1_HUMAN	Protein bicaudal C homolog 1 (Bic-C)	BICC1	Homo sapiens (Human)	974	FUNCTION: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}.		determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; kidney development [GO:0001822]; negative regulation of canonical Wnt signaling pathway [GO:0090090]	cytoplasm [GO:0005737]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; RNA binding [GO:0003723]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; kidney development [GO:0001822]; negative regulation of canonical Wnt signaling pathway [GO:0090090]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9H6B4	reviewed	CLMP_HUMAN	CXADR-like membrane protein (Adipocyte adhesion molecule) (Coxsackie- and adenovirus receptor-like membrane protein) (CAR-like membrane protein)	CLMP ACAM ASAM UNQ318/PRO363	Homo sapiens (Human)	373	FUNCTION: May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development. {ECO:0000269|PubMed:14573622, ECO:0000269|PubMed:15563274, ECO:0000269|PubMed:22155368}.		digestive tract development [GO:0048565]	bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; cytoplasmic microtubule [GO:0005881]; plasma membrane [GO:0005886]		bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; cytoplasmic microtubule [GO:0005881]; plasma membrane [GO:0005886]; digestive tract development [GO:0048565]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:14573622, ECO:0000269|PubMed:22155368}. Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9H6B9	reviewed	EPHX3_HUMAN	Epoxide hydrolase 3 (EH3) (EC 3.3.2.10) (Abhydrolase domain-containing protein 9)	EPHX3 ABHD9	Homo sapiens (Human)	360	FUNCTION: Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin. {ECO:0000269|PubMed:22798687}.		epoxide metabolic process [GO:0097176]; lipid metabolic process [GO:0006629]	endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	epoxide hydrolase activity [GO:0004301]; hydrolase activity [GO:0016787]	endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; epoxide hydrolase activity [GO:0004301]; hydrolase activity [GO:0016787]; epoxide metabolic process [GO:0097176]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305|PubMed:22798687}; Single-pass membrane protein {ECO:0000255}.
Q9H6D3	reviewed	XKR8_HUMAN	XK-related protein 8 (hXkr8) [Cleaved into: XK-related protein 8, processed form]	XKR8 XRG8	Homo sapiens (Human)	395	FUNCTION: [XK-related protein 8, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:25231987). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:23845944). Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina (By similarity). Has no effect on calcium-induced exposure of phosphatidylserine (PubMed:23845944). Promotes myoblast differentiation and survival (PubMed:28881496). {ECO:0000250|UniProtKB:Q8C0T0, ECO:0000269|PubMed:23845944, ECO:0000269|PubMed:25231987, ECO:0000269|PubMed:28881496}.; FUNCTION: (Microbial infection) Incorporated into Ebola virus-like particles, where its phospholipid scramblase activity is required to promote phosphatidylserine exposure on the surface of viral particles (PubMed:29338048). Externalization of phosphatidylserine on the surface of viral particles is required for uptake by host cells (PubMed:29338048). {ECO:0000269|PubMed:29338048}.	MISCELLANEOUS: Expression is repressed in PLB-985 leukemia and Raji lymphoma cells due to CpG methylation near the transcription start site of XKR8 gene, possibly explaining the inability of PLB-985 leukemia and Raji lymphoma cells to expose phosphatidylserine during apoptosis. {ECO:0000305|PubMed:23845944}.	apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; establishment of localization in cell [GO:0051649]; neutrophil clearance [GO:0097350]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]; positive regulation of myoblast differentiation [GO:0045663]; tolerance induction to self antigen [GO:0002513]	perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	phospholipid scramblase activity [GO:0017128]	perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; phospholipid scramblase activity [GO:0017128]; apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; establishment of localization in cell [GO:0051649]; neutrophil clearance [GO:0097350]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]; positive regulation of myoblast differentiation [GO:0045663]; tolerance induction to self antigen [GO:0002513]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23845944, ECO:0000269|PubMed:27503893, ECO:0000269|PubMed:28881496}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:28881496}.
Q9H6D7	reviewed	HAUS4_HUMAN	HAUS augmin-like complex subunit 4	HAUS4 C14orf94	Homo sapiens (Human)	363	FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.		cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]	microtubule minus-end binding [GO:0051011]	centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; microtubule minus-end binding [GO:0051011]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}.
Q9H6E4	reviewed	CC134_HUMAN	Coiled-coil domain-containing protein 134	CCDC134	Homo sapiens (Human)	229	FUNCTION: In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). Has a critical role in the regulation of osteogenesis and bone development (PubMed:32181939). {ECO:0000269|PubMed:18087676, ECO:0000269|PubMed:23070808, ECO:0000269|PubMed:25125657, ECO:0000269|PubMed:32181939}.; FUNCTION: In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. {ECO:0000269|PubMed:22644376}.		angiogenesis [GO:0001525]; embryonic hemopoiesis [GO:0035162]; embryonic liver development [GO:1990402]; placenta development [GO:0001890]; regulation of ossification [GO:0030278]; ventricular system development [GO:0021591]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]		cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; angiogenesis [GO:0001525]; embryonic hemopoiesis [GO:0035162]; embryonic liver development [GO:1990402]; placenta development [GO:0001890]; regulation of ossification [GO:0030278]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22644376}. Cytoplasm {ECO:0000269|PubMed:22644376}. Secreted {ECO:0000269|PubMed:18087676}. Endoplasmic reticulum {ECO:0000269|PubMed:18087676}. Note=Accumulates in the nucleus in response to UV irradiation (PubMed:22644376). {ECO:0000269|PubMed:22644376}.
Q9H6E5	reviewed	STPAP_HUMAN	Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52)	TUT1 RBM21	Homo sapiens (Human)	874	FUNCTION: Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs (PubMed:18288197, PubMed:21102410). Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 (PubMed:18288197). In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs (PubMed:21102410). In addition to adenylyltransferase activity, also has uridylyltransferase activity (PubMed:16790842, PubMed:18288197, PubMed:28589955). However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (PubMed:18288197). Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA (PubMed:16790842, PubMed:18288197, PubMed:28589955). Not involved in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16790842, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:21102410, ECO:0000269|PubMed:28589955}.		mRNA polyadenylation [GO:0006378]; snRNA processing [GO:0016180]; U6 snRNA 3'-end processing [GO:0034477]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; enzyme-substrate adaptor activity [GO:0140767]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; U6 snRNA binding [GO:0017070]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; enzyme-substrate adaptor activity [GO:0140767]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; U6 snRNA binding [GO:0017070]; mRNA polyadenylation [GO:0006378]; snRNA processing [GO:0016180]; U6 snRNA 3'-end processing [GO:0034477]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16790842}. Nucleus speckle {ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:18305108}.
Q9H6H4	reviewed	REEP4_HUMAN	Receptor expression-enhancing protein 4	REEP4 C8orf20 PP432	Homo sapiens (Human)	257	FUNCTION: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes. {ECO:0000269|PubMed:23911198}.		cell division [GO:0051301]; endoplasmic reticulum tubular network organization [GO:0071786]; mitotic nuclear membrane reassembly [GO:0007084]; nuclear envelope organization [GO:0006998]	cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]	microtubule binding [GO:0008017]	cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; microtubule binding [GO:0008017]; cell division [GO:0051301]; endoplasmic reticulum tubular network organization [GO:0071786]; mitotic nuclear membrane reassembly [GO:0007084]; nuclear envelope organization [GO:0006998]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23911198}; Multi-pass membrane protein {ECO:0000269|PubMed:23911198}.
Q9H6I2	reviewed	SOX17_HUMAN	Transcription factor SOX-17	SOX17	Homo sapiens (Human)	414	FUNCTION: Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells. {ECO:0000250|UniProtKB:Q61473}.		anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; cardiac cell fate determination [GO:0060913]; cardiogenic plate morphogenesis [GO:0003142]; cell migration involved in gastrulation [GO:0042074]; cellular response to leukemia inhibitory factor [GO:1990830]; common bile duct development [GO:0061009]; embryonic foregut morphogenesis [GO:0048617]; embryonic heart tube development [GO:0035050]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cell differentiation [GO:0060956]; endocardium formation [GO:0060214]; endoderm formation [GO:0001706]; endodermal cell fate determination [GO:0007493]; endodermal cell fate specification [GO:0001714]; endodermal digestive tract morphogenesis [GO:0061031]; gallbladder development [GO:0061010]; gene expression [GO:0010467]; heart development [GO:0007507]; heart formation [GO:0060914]; heart looping [GO:0001947]; inner cell mass cellular morphogenesis [GO:0001828]; metanephros development [GO:0001656]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of Wnt signaling pathway involved in heart development [GO:0003308]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endodermal cell differentiation [GO:1903226]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; regulation of cardiac cell fate specification [GO:2000043]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of stem cell division [GO:2000035]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription by RNA polymerase II [GO:0006357]; rostrocaudal neural tube patterning [GO:0021903]; signal transduction involved in regulation of gene expression [GO:0023019]; spermatogenesis [GO:0007283]; stem cell fate specification [GO:0048866]; ureter development [GO:0072189]; vasculogenesis [GO:0001570]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	beta-catenin binding [GO:0008013]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; beta-catenin binding [GO:0008013]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; cardiac cell fate determination [GO:0060913]; cardiogenic plate morphogenesis [GO:0003142]; cell migration involved in gastrulation [GO:0042074]; cellular response to leukemia inhibitory factor [GO:1990830]; common bile duct development [GO:0061009]; embryonic foregut morphogenesis [GO:0048617]; embryonic heart tube development [GO:0035050]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cell differentiation [GO:0060956]; endocardium formation [GO:0060214]; endoderm formation [GO:0001706]; endodermal cell fate determination [GO:0007493]; endodermal cell fate specification [GO:0001714]; endodermal digestive tract morphogenesis [GO:0061031]; gallbladder development [GO:0061010]; gene expression [GO:0010467]; heart development [GO:0007507]; heart formation [GO:0060914]; heart looping [GO:0001947]; inner cell mass cellular morphogenesis [GO:0001828]; metanephros development [GO:0001656]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of Wnt signaling pathway involved in heart development [GO:0003308]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endodermal cell differentiation [GO:1903226]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; regulation of cardiac cell fate specification [GO:2000043]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of stem cell division [GO:2000035]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription by RNA polymerase II [GO:0006357]; rostrocaudal neural tube patterning [GO:0021903]; signal transduction involved in regulation of gene expression [GO:0023019]; spermatogenesis [GO:0007283]; stem cell fate specification [GO:0048866]; ureter development [GO:0072189]; vasculogenesis [GO:0001570]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Q9H6J7	reviewed	CSTP1_HUMAN	Centriolar satellite-associated tubulin polyglutamylase complex regulator 1	CSTPP1 C11orf49	Homo sapiens (Human)	331	FUNCTION: Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly (PubMed:34782749). Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding (PubMed:34782749). {ECO:0000269|PubMed:34782749}.		regulation of protein complex stability [GO:0061635]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; microtubule [GO:0005874]	protein-macromolecule adaptor activity [GO:0030674]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; protein-macromolecule adaptor activity [GO:0030674]; regulation of protein complex stability [GO:0061635]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:34782749}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:34782749}. Note=Associated with microtubules. {ECO:0000269|PubMed:34782749}.
Q9H6K1	reviewed	ILRUN_HUMAN	Protein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein)	ILRUN C6orf106	Homo sapiens (Human)	298	FUNCTION: Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199). {ECO:0000269|PubMed:29802199}.		innate immune response [GO:0045087]; macroautophagy [GO:0016236]; negative regulation of defense response to virus [GO:0050687]; negative regulation of DNA binding [GO:0043392]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon production [GO:0032480]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; phagophore assembly site [GO:0000407]	ubiquitin binding [GO:0043130]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; phagophore assembly site [GO:0000407]; ubiquitin binding [GO:0043130]; innate immune response [GO:0045087]; macroautophagy [GO:0016236]; negative regulation of defense response to virus [GO:0050687]; negative regulation of DNA binding [GO:0043392]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon production [GO:0032480]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25736925, ECO:0000269|PubMed:29802199}. Nucleus {ECO:0000269|PubMed:29802199}.
Q9H6L2	reviewed	TM231_HUMAN	Transmembrane protein 231	TMEM231 UNQ870/PRO1886	Homo sapiens (Human)	316	FUNCTION: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250}.		camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224]; vasculature development [GO:0001944]	ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; MKS complex [GO:0036038]		ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; MKS complex [GO:0036038]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224]; vasculature development [GO:0001944]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the transition zone of primary cilia; SEPT2 is required for localization to the transition zone. {ECO:0000250}.
Q9H6L4	reviewed	ARMC7_HUMAN	Armadillo repeat-containing protein 7	ARMC7	Homo sapiens (Human)	198	FUNCTION: As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. {ECO:0000305|PubMed:33509932}.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	spliceosomal complex [GO:0005681]		spliceosomal complex [GO:0005681]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	
Q9H6L5	reviewed	RETR1_HUMAN	Reticulophagy regulator 1 (Reticulophagy receptor 1)	RETREG1 FAM134B JK1	Homo sapiens (Human)	497	FUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:31930741, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:31930741, PubMed:34338405). Active under basal conditions (PubMed:34338405). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720). {ECO:0000250|UniProtKB:Q8VE91, ECO:0000269|PubMed:19838196, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:34338405}.; FUNCTION: (Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein (PubMed:35239449). This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:35239449}.		collagen catabolic process [GO:0030574]; endoplasmic reticulum organization [GO:0007029]; mitophagy [GO:0000423]; negative regulation of neuron apoptotic process [GO:0043524]; reticulophagy [GO:0061709]; sensory perception of pain [GO:0019233]; white fat cell differentiation [GO:0050872]	cis-Golgi network [GO:0005801]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear body [GO:0016604]; nucleolus [GO:0005730]	endoplasmic reticulum-autophagosome adaptor activity [GO:0140506]; protein self-association [GO:0043621]	cis-Golgi network [GO:0005801]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; endoplasmic reticulum-autophagosome adaptor activity [GO:0140506]; protein self-association [GO:0043621]; collagen catabolic process [GO:0030574]; endoplasmic reticulum organization [GO:0007029]; mitophagy [GO:0000423]; negative regulation of neuron apoptotic process [GO:0043524]; reticulophagy [GO:0061709]; sensory perception of pain [GO:0019233]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q8VE91}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:26040720}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:35239449}; Multi-pass membrane protein {ECO:0000255}. Note=(Microbial infection) Following SARS-CoV-2 infection, colocalizes with SARS-CoV-2 ORF3A protein at the endoplasmic reticulum. {ECO:0000269|PubMed:35239449}.
Q9H6P5	reviewed	TASP1_HUMAN	Threonine aspartase 1 (Taspase-1) (EC 3.4.25.-) [Cleaved into: Threonine aspartase subunit alpha; Threonine aspartase subunit beta]	TASP1 C20orf13	Homo sapiens (Human)	420	FUNCTION: Protease responsible for KMT2A/MLL1 processing and activation (PubMed:14636557). It also activates KMT2D/MLL2 (By similarity). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (By similarity) (PubMed:14636557). {ECO:0000250|UniProtKB:Q8R1G1, ECO:0000269|PubMed:14636557}.		epigenetic regulation of gene expression [GO:0040029]; positive regulation of DNA-templated transcription [GO:0045893]; protein maturation [GO:0051604]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	asparaginase activity [GO:0004067]; beta-aspartyl-peptidase activity [GO:0008798]; identical protein binding [GO:0042802]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; asparaginase activity [GO:0004067]; beta-aspartyl-peptidase activity [GO:0008798]; identical protein binding [GO:0042802]; threonine-type endopeptidase activity [GO:0004298]; epigenetic regulation of gene expression [GO:0040029]; positive regulation of DNA-templated transcription [GO:0045893]; protein maturation [GO:0051604]; proteolysis [GO:0006508]	
Q9H6Q3	reviewed	SLAP2_HUMAN	Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)	SLA2 C20orf156 SLAP2	Homo sapiens (Human)	261	FUNCTION: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:11696592}.	MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation at Met-28 of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative initiation at Met-28 of isoform 2. {ECO:0000305}.	antigen receptor-mediated signaling pathway [GO:0050851]; B cell mediated immunity [GO:0019724]; negative regulation of calcium-mediated signaling [GO:0050849]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; regulation of immune response [GO:0050776]; T cell activation [GO:0042110]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; signaling adaptor activity [GO:0035591]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; signaling adaptor activity [GO:0035591]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell mediated immunity [GO:0019724]; negative regulation of calcium-mediated signaling [GO:0050849]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; regulation of immune response [GO:0050776]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}. Note=May be cytoplasmic and is not localized to membranes.
Q9H6Q4	reviewed	CIAO3_HUMAN	Cytosolic iron-sulfur assembly component 3 (Cytosolic Fe-S cluster assembly factor NARFL) (Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) (Protein related to Narf)	CIAO3 NARFL PRN	Homo sapiens (Human)	476	FUNCTION: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. {ECO:0000269|PubMed:16956324, ECO:0000269|PubMed:18270200}.		hematopoietic progenitor cell differentiation [GO:0002244]; intracellular oxygen homeostasis [GO:0032364]; iron-sulfur cluster assembly [GO:0016226]; regulation of gene expression [GO:0010468]; response to hypoxia [GO:0001666]	CIA complex [GO:0097361]	4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]	CIA complex [GO:0097361]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular oxygen homeostasis [GO:0032364]; iron-sulfur cluster assembly [GO:0016226]; regulation of gene expression [GO:0010468]; response to hypoxia [GO:0001666]	
Q9H6R0	reviewed	DHX33_HUMAN	ATP-dependent RNA helicase DHX33 (EC 3.6.4.13) (DEAH box protein 33)	DHX33 DDX33	Homo sapiens (Human)	707	FUNCTION: Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (PubMed:23871209). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (PubMed:23871209). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity). {ECO:0000250|UniProtKB:Q80VY9, ECO:0000269|PubMed:21930779, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:26100019}.		positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of type I interferon production [GO:0032481]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; NLRP3 inflammasome complex [GO:0072559]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA-binding transcription factor binding [GO:0140297]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; mRNA binding [GO:0003729]; rDNA binding [GO:0000182]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; NLRP3 inflammasome complex [GO:0072559]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA-binding transcription factor binding [GO:0140297]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; mRNA binding [GO:0003729]; rDNA binding [GO:0000182]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of type I interferon production [GO:0032481]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21930779, ECO:0000269|PubMed:26100019}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21930779}. Cytoplasm {ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:26100019}. Nucleus {ECO:0000269|PubMed:23871209}. Inflammasome {ECO:0000269|PubMed:23871209}. Note=Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions (PubMed:21930779). Upon dsRNA-binding, localizes in the inflammasome (PubMed:23871209). {ECO:0000269|PubMed:21930779, ECO:0000269|PubMed:23871209}.
Q9H6R3	reviewed	ACSS3_HUMAN	Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 3) (Acyl-CoA synthetase short-chain family member 3) (Propionate--CoA ligase) (EC 6.2.1.17)	ACSS3	Homo sapiens (Human)	686	FUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:28003429). Propionate is the preferred substrate (PubMed:28003429). Can utilize acetate and butyrate with a much lower affinity (By similarity). {ECO:0000250|UniProtKB:A0A0G2K047, ECO:0000269|PubMed:28003429}.		ketone body biosynthetic process [GO:0046951]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	acetate-CoA ligase activity [GO:0003987]; ATP binding [GO:0005524]; butyrate-CoA ligase activity [GO:0047760]; propionate-CoA ligase activity [GO:0050218]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; acetate-CoA ligase activity [GO:0003987]; ATP binding [GO:0005524]; butyrate-CoA ligase activity [GO:0047760]; propionate-CoA ligase activity [GO:0050218]; ketone body biosynthetic process [GO:0046951]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:28003429}.
Q9H6R4	reviewed	NOL6_HUMAN	Nucleolar protein 6 (Nucleolar RNA-associated protein) (Nrap)	NOL6	Homo sapiens (Human)	1146	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:11895476, ECO:0000269|PubMed:34516797}.		ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; tRNA export from nucleus [GO:0006409]	condensed nuclear chromosome [GO:0000794]; CURI complex [GO:0032545]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; UTP-C complex [GO:0034456]	RNA binding [GO:0003723]	condensed nuclear chromosome [GO:0000794]; CURI complex [GO:0032545]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; UTP-C complex [GO:0034456]; RNA binding [GO:0003723]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; tRNA export from nucleus [GO:0006409]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:34516797}. Chromosome {ECO:0000250|UniProtKB:Q8R5K4}. Note=Localizes to condensed chromosomes in mitosis. {ECO:0000250|UniProtKB:Q8R5K4}.
Q9H6R6	reviewed	ZDHC6_HUMAN	Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Stearoyltransferase ZDHHC6) (EC 2.3.1.-) (Transmembrane protein H4) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) (Zinc finger protein 376)	ZDHHC6 ZNF376	Homo sapiens (Human)	413	FUNCTION: Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:22314232, PubMed:22728137, PubMed:25368151, PubMed:28826475). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (PubMed:22314232). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (PubMed:22728137). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation (PubMed:26214738). {ECO:0000269|PubMed:22314232, ECO:0000269|PubMed:22728137, ECO:0000269|PubMed:25368151, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:28826475}.		positive regulation of mitochondrial fusion [GO:0010636]; protein palmitoylation [GO:0018345]; protein stearoylation [GO:0140438]; protein targeting to membrane [GO:0006612]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; positive regulation of mitochondrial fusion [GO:0010636]; protein palmitoylation [GO:0018345]; protein stearoylation [GO:0140438]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21926431, ECO:0000269|PubMed:22314232, ECO:0000269|PubMed:28826475}; Multi-pass membrane protein {ECO:0000255}. Note=When not palmitoylated, accumulates to dot-like structures in the endoplasmic reticulum (PubMed:28826475). {ECO:0000269|PubMed:28826475}.
Q9H6R7	reviewed	WDCP_HUMAN	WD repeat and coiled-coil-containing protein	WDCP C2orf44 PP384	Homo sapiens (Human)	721			protein complex oligomerization [GO:0051259]		kinase binding [GO:0019900]	kinase binding [GO:0019900]; protein complex oligomerization [GO:0051259]	
Q9H6S0	reviewed	YTDC2_HUMAN	3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2)	YTHDC2	Homo sapiens (Human)	1430	FUNCTION: 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}.		germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; meiotic cell cycle [GO:0051321]; oocyte development [GO:0048599]; positive regulation by host of viral genome replication [GO:0044829]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; spermatid development [GO:0007286]	endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein granule [GO:0035770]	3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; helicase activity [GO:0004386]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]	endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein granule [GO:0035770]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; helicase activity [GO:0004386]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; meiotic cell cycle [GO:0051321]; oocyte development [GO:0048599]; positive regulation by host of viral genome replication [GO:0044829]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B2RR83}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:29970596}.
Q9H6S1	reviewed	AZI2_HUMAN	5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP)	AZI2 NAP1 TBKBP2	Homo sapiens (Human)	392	FUNCTION: Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223). {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}.		canonical NF-kappaB signal transduction [GO:0007249]; defense response to virus [GO:0051607]; dendritic cell differentiation [GO:0097028]; dendritic cell proliferation [GO:0044565]; mitotic cell cycle [GO:0000278]; T cell activation [GO:0042110]; type I interferon-mediated signaling pathway [GO:0060337]	cytoplasm [GO:0005737]; serine/threonine protein kinase complex [GO:1902554]		cytoplasm [GO:0005737]; serine/threonine protein kinase complex [GO:1902554]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to virus [GO:0051607]; dendritic cell differentiation [GO:0097028]; dendritic cell proliferation [GO:0044565]; mitotic cell cycle [GO:0000278]; T cell activation [GO:0042110]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14560022}.
Q9H6S3	reviewed	ES8L2_HUMAN	Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)	EPS8L2 EPS8R2 PP13181	Homo sapiens (Human)	715	FUNCTION: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}.		positive regulation of ruffle assembly [GO:1900029]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]; sensory perception of sound [GO:0007605]	centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; stereocilium bundle [GO:0032421]; stereocilium tip [GO:0032426]; vesicle [GO:0031982]	actin binding [GO:0003779]; cadherin binding [GO:0045296]	centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; stereocilium bundle [GO:0032421]; stereocilium tip [GO:0032426]; vesicle [GO:0031982]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; positive regulation of ruffle assembly [GO:1900029]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14565974}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q99K30}. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells. {ECO:0000250|UniProtKB:Q99K30}.
Q9H6T0	reviewed	ESRP2_HUMAN	Epithelial splicing regulatory protein 2 (RNA-binding motif protein 35B) (RNA-binding protein 35B)	ESRP2 RBM35B PP7059	Homo sapiens (Human)	727	FUNCTION: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. {ECO:0000269|PubMed:19285943}.		alternative mRNA splicing, via spliceosome [GO:0000380]; branching involved in salivary gland morphogenesis [GO:0060445]; epithelial cell proliferation [GO:0050673]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of RNA splicing [GO:0043484]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; alternative mRNA splicing, via spliceosome [GO:0000380]; branching involved in salivary gland morphogenesis [GO:0060445]; epithelial cell proliferation [GO:0050673]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19285943}.
Q9H6T3	reviewed	RPAP3_HUMAN	RNA polymerase II-associated protein 3	RPAP3	Homo sapiens (Human)	665	FUNCTION: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}.		protein stabilization [GO:0050821]	cytosol [GO:0005829]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]		cytosol [GO:0005829]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; protein stabilization [GO:0050821]	
Q9H6U6	reviewed	BCAS3_HUMAN	BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1)	BCAS3	Homo sapiens (Human)	928	FUNCTION: Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}.		angiogenesis [GO:0001525]; autophagy [GO:0006914]; cell-cell signaling [GO:0007267]; cellular response to estrogen stimulus [GO:0071391]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin cytoskeleton organization [GO:0032956]; response to estrogen [GO:0043627]; response to starvation [GO:0042594]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; euchromatin [GO:0000791]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; phagophore assembly site [GO:0000407]	acetyltransferase activator activity [GO:0010698]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; histone acetyltransferase binding [GO:0035035]; histone binding [GO:0042393]; nuclear receptor binding [GO:0016922]; phosphatidylinositol binding [GO:0035091]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; euchromatin [GO:0000791]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; phagophore assembly site [GO:0000407]; acetyltransferase activator activity [GO:0010698]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; histone acetyltransferase binding [GO:0035035]; histone binding [GO:0042393]; nuclear receptor binding [GO:0016922]; phosphatidylinositol binding [GO:0035091]; angiogenesis [GO:0001525]; autophagy [GO:0006914]; cell-cell signaling [GO:0007267]; cellular response to estrogen stimulus [GO:0071391]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin cytoskeleton organization [GO:0032956]; response to estrogen [GO:0043627]; response to starvation [GO:0042594]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17505058}. Cytoplasm {ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:18030336, ECO:0000269|PubMed:33499712}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8CCN5}. Preautophagosomal structure {ECO:0000269|PubMed:33499712}. Note=Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity). Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}.
Q9H6U8	reviewed	ALG9_HUMAN	Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9 homolog) (Disrupted in bipolar disorder protein 1) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase)	ALG9 DIBD1	Homo sapiens (Human)	611	FUNCTION: Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides. {ECO:0000269|PubMed:15148656, ECO:0000269|PubMed:15945070}.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	alpha-1,2-mannosyltransferase activity [GO:0000026]; dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0052926]; dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0052918]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; alpha-1,2-mannosyltransferase activity [GO:0000026]; dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0052926]; dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0052918]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:15148656}; Multi-pass membrane protein {ECO:0000305}.
Q9H6W3	reviewed	RIOX1_HUMAN	Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX)	RIOX1 C14orf169 MAPJD NO66	Homo sapiens (Human)	641	FUNCTION: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:23103944). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (PubMed:23103944). Participates in MYC-induced transcriptional activation (PubMed:17308053). {ECO:0000250|UniProtKB:Q9JJF3, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; iron ion binding [GO:0005506]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein demethylase activity [GO:0140457]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; iron ion binding [GO:0005506]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein demethylase activity [GO:0140457]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:14742713, ECO:0000269|PubMed:17308053}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17308053}. Note=Granular part of nucleoli (PubMed:14742713). Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli (PubMed:14742713). {ECO:0000269|PubMed:14742713}.
Q9H6X2	reviewed	ANTR1_HUMAN	Anthrax toxin receptor 1 (Tumor endothelial marker 8)	ANTXR1 ATR TEM8	Homo sapiens (Human)	564	FUNCTION: Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. {ECO:0000269|PubMed:15777794, ECO:0000269|PubMed:16762926}.; FUNCTION: (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. {ECO:0000269|PubMed:11700562, ECO:0000269|PubMed:12700348, ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:20585457}.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; MISCELLANEOUS: [Isoform 6]: Prostate-specific. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; blood vessel development [GO:0001568]; negative regulation of extracellular matrix assembly [GO:1901202]; reproductive process [GO:0022414]; substrate adhesion-dependent cell spreading [GO:0034446]	cell surface [GO:0009986]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; filopodium membrane [GO:0031527]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; collagen binding [GO:0005518]; metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; filopodium membrane [GO:0031527]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; collagen binding [GO:0005518]; metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888]; actin cytoskeleton organization [GO:0030036]; blood vessel development [GO:0001568]; negative regulation of extracellular matrix assembly [GO:1901202]; reproductive process [GO:0022414]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, filopodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia (PubMed:16762926). Colocalizes with actin at the base of lamellipodia (PubMed:16762926). {ECO:0000269|PubMed:16762926}.
Q9H6Y7	reviewed	RN167_HUMAN	E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167)	RNF167 RING105 LP2254	Homo sapiens (Human)	350	FUNCTION: E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway (PubMed:35114100, PubMed:33594058). Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 (PubMed:33594058). Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Also involved in protein trafficking and localization (PubMed:23129617, PubMed:23353890, PubMed:24387786, PubMed:27808481, PubMed:32409562). Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 (PubMed:23129617, PubMed:33650289). Does not catalyze ubiquitination of GluA1/GRIA1 (PubMed:23129617). Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 (PubMed:23353890). Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B (PubMed:27808481). Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 (PubMed:16314844). Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N (PubMed:33650289). {ECO:0000269|PubMed:16314844, ECO:0000269|PubMed:23129617, ECO:0000269|PubMed:23353890, ECO:0000269|PubMed:24387786, ECO:0000269|PubMed:27808481, ECO:0000269|PubMed:32409562, ECO:0000269|PubMed:33594058, ECO:0000269|PubMed:33650289, ECO:0000269|PubMed:35114100}.		cellular response to leucine starvation [GO:1990253]; lysosome localization [GO:0032418]; negative regulation of cell cycle [GO:0045786]; negative regulation of TORC1 signaling [GO:1904262]; organelle localization [GO:0051640]; positive regulation of TORC1 signaling [GO:1904263]; protein polyubiquitination [GO:0000209]; regulation of synaptic transmission, glutamatergic [GO:0051966]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome [GO:0005768]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome [GO:0005768]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; cellular response to leucine starvation [GO:1990253]; lysosome localization [GO:0032418]; negative regulation of cell cycle [GO:0045786]; negative regulation of TORC1 signaling [GO:1904262]; organelle localization [GO:0051640]; positive regulation of TORC1 signaling [GO:1904263]; protein polyubiquitination [GO:0000209]; regulation of synaptic transmission, glutamatergic [GO:0051966]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:16314844, ECO:0000269|PubMed:27808481, ECO:0000269|PubMed:35114100}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:24387786}; Single-pass type I membrane protein {ECO:0000255}. Endomembrane system {ECO:0000269|PubMed:16314844}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:23129617}; Single-pass type I membrane protein {ECO:0000255}. Note=Targeted to cytoplasmic membranes; mainly localizes to lysosomal membrane (PubMed:16314844, PubMed:23129617). A subpopulation localizes to the cell membrane of neurons (PubMed:23129617). {ECO:0000269|PubMed:16314844, ECO:0000269|PubMed:23129617}.; SUBCELLULAR LOCATION: [Isoform 1]: Lysosome membrane {ECO:0000269|PubMed:32409562}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:32409562}.
Q9H6Z4	reviewed	RANB3_HUMAN	Ran-binding protein 3 (RanBP3)	RANBP3	Homo sapiens (Human)	567	FUNCTION: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}.		protein export from nucleus [GO:0006611]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	R-SMAD binding [GO:0070412]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; R-SMAD binding [GO:0070412]; small GTPase binding [GO:0031267]; protein export from nucleus [GO:0006611]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19289081}. Nucleus {ECO:0000269|PubMed:19289081}.
Q9H6Z9	reviewed	EGLN3_HUMAN	Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3)	EGLN3	Homo sapiens (Human)	239	FUNCTION: Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as PKM, TELO2, ATF4 and HIF1A (PubMed:19584355, PubMed:21620138, PubMed:21483450, PubMed:22797300, PubMed:20978507, PubMed:21575608). Target proteins are preferentially recognized via a LXXLAP motif. Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12181324). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12181324). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12181324). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12181324). Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site (PubMed:11595184, PubMed:12181324). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12181324). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12181324). ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis (PubMed:21620138, PubMed:21483450). Under normoxia, hydroxylates and regulates the stability of ADRB2 (PubMed:19584355). Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex (PubMed:20849813). In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity (PubMed:16098468). Also essential for hypoxic regulation of neutrophilic inflammation (PubMed:21317538). Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway (PubMed:22797300). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (Probable). {ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:16098468, ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:20849813, ECO:0000269|PubMed:20978507, ECO:0000269|PubMed:21317538, ECO:0000269|PubMed:21483450, ECO:0000269|PubMed:21575608, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22797300, ECO:0000305|PubMed:17684156}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; protein hydroxylation [GO:0018126]; regulation of cell population proliferation [GO:0042127]; regulation of neuron apoptotic process [GO:0043523]; response to hypoxia [GO:0001666]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; protein hydroxylation [GO:0018126]; regulation of cell population proliferation [GO:0042127]; regulation of neuron apoptotic process [GO:0043523]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:12615973}. Cytoplasm {ECO:0000269|PubMed:12615973}. Note=Colocalizes with WDR83 in the cytoplasm. {ECO:0000250|UniProtKB:Q62630}.
Q9H706	reviewed	GARE1_HUMAN	GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)	GAREM1 C18orf11 FAM59A GAREM	Homo sapiens (Human)	876	FUNCTION: [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}.		cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	plasma membrane [GO:0005886]	proline-rich region binding [GO:0070064]	plasma membrane [GO:0005886]; proline-rich region binding [GO:0070064]; cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	
Q9H707	reviewed	ZN552_HUMAN	Zinc finger protein 552	ZNF552	Homo sapiens (Human)	407	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H714	reviewed	PACER_HUMAN	Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like)	RUBCNL C13orf18 KIAA0226L	Homo sapiens (Human)	662	FUNCTION: Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable). {ECO:0000250|UniProtKB:Q3TD16, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:30704899, ECO:0000305|PubMed:23522960}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	autophagosome maturation [GO:0097352]; autophagosome-endosome fusion [GO:0061910]; autophagosome-lysosome fusion [GO:0061909]; lipid metabolic process [GO:0006629]; regulation of glycogen metabolic process [GO:0070873]; regulation of lipid metabolic process [GO:0019216]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231]	phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; autophagosome maturation [GO:0097352]; autophagosome-endosome fusion [GO:0061910]; autophagosome-lysosome fusion [GO:0061909]; lipid metabolic process [GO:0006629]; regulation of glycogen metabolic process [GO:0070873]; regulation of lipid metabolic process [GO:0019216]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:28306502}; Peripheral membrane protein {ECO:0000269|PubMed:28306502}. Note=Associates with late autophagic structure (PubMed:28306502). Recruitment to autophagosome membrane is promoted by autophagic stimuli (PubMed:28306502). {ECO:0000269|PubMed:28306502}.
Q9H741	reviewed	SPRNG_HUMAN	SREBP regulating gene protein (SREBF pathway regulator in Golgi 1)	SPRING1 C12orf49 SPRING	Homo sapiens (Human)	205	FUNCTION: Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP. {ECO:0000269|PubMed:32111832}.		positive regulation of SREBP signaling pathway [GO:2000640]	Golgi membrane [GO:0000139]		Golgi membrane [GO:0000139]; positive regulation of SREBP signaling pathway [GO:2000640]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:32111832}; Single-pass membrane protein {ECO:0000255}.
Q9H772	reviewed	GREM2_HUMAN	Gremlin-2 (Cysteine knot superfamily 1, BMP antagonist 2) (DAN domain family member 3) (Protein related to DAN and cerberus)	GREM2 CKTSF1B2 DAND3 PRDC	Homo sapiens (Human)	168	FUNCTION: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells. {ECO:0000250|UniProtKB:O88273}.		animal organ morphogenesis [GO:0009887]; cytokine-mediated signaling pathway [GO:0019221]; determination of dorsal identity [GO:0048263]; embryonic body morphogenesis [GO:0010172]; regulation of cytokine activity [GO:0060300]; sequestering of BMP from receptor via BMP binding [GO:0038098]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	BMP binding [GO:0036122]; cytokine activity [GO:0005125]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; BMP binding [GO:0036122]; cytokine activity [GO:0005125]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018]; animal organ morphogenesis [GO:0009887]; cytokine-mediated signaling pathway [GO:0019221]; determination of dorsal identity [GO:0048263]; embryonic body morphogenesis [GO:0010172]; regulation of cytokine activity [GO:0060300]; sequestering of BMP from receptor via BMP binding [GO:0038098]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H773	reviewed	DCTP1_HUMAN	dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein)	DCTPP1 XTP3TPA CDA03	Homo sapiens (Human)	170	FUNCTION: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}.		dCTP catabolic process [GO:0006253]; DNA protection [GO:0042262]; nucleoside triphosphate catabolic process [GO:0009143]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	dCTP diphosphatase activity [GO:0047840]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleoside triphosphate diphosphatase activity [GO:0047429]; pyrimidine deoxyribonucleotide binding [GO:0032556]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; dCTP diphosphatase activity [GO:0047840]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleoside triphosphate diphosphatase activity [GO:0047429]; pyrimidine deoxyribonucleotide binding [GO:0032556]; dCTP catabolic process [GO:0006253]; DNA protection [GO:0042262]; nucleoside triphosphate catabolic process [GO:0009143]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:24467396}. Nucleus {ECO:0000269|PubMed:24467396}. Cytoplasm, cytosol {ECO:0000269|PubMed:24467396}.
Q9H777	reviewed	RNZ1_HUMAN	Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Deleted in Ma29) (ElaC homolog protein 1) (Ribonuclease Z 1) (RNase Z 1) (tRNA 3 endonuclease 1) (tRNase Z 1)	ELAC1 D29	Homo sapiens (Human)	363	FUNCTION: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity (PubMed:12711671, PubMed:32075755). Specifically involved in tRNA repair: acts downstream of the ribosome-associated quality control (RQC) pathway by removing a 2',3'-cyclic phosphate from tRNAs following cleavage by ANKZF1 (PubMed:32075755). tRNAs are then processed by TRNT1 (PubMed:32075755). {ECO:0000269|PubMed:12711671, ECO:0000269|PubMed:32075755}.		rescue of stalled ribosome [GO:0072344]; tRNA 3'-end processing [GO:0042780]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-tRNA processing endoribonuclease activity [GO:0042781]; metal ion binding [GO:0046872]; tRNA-specific ribonuclease activity [GO:0004549]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-tRNA processing endoribonuclease activity [GO:0042781]; metal ion binding [GO:0046872]; tRNA-specific ribonuclease activity [GO:0004549]; rescue of stalled ribosome [GO:0072344]; tRNA 3'-end processing [GO:0042780]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21593607}. Nucleus {ECO:0000269|PubMed:21593607}. Note=Mainly cytosolic. {ECO:0000269|PubMed:21593607}.
Q9H788	reviewed	SH24A_HUMAN	SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)	SH2D4A PPP1R38 SH2A	Homo sapiens (Human)	454	FUNCTION: Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubMed:18641339, ECO:0000269|PubMed:19712589}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]	phosphatase binding [GO:0019902]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphatase binding [GO:0019902]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18641339}. Note=Located at podocyte foot processes. {ECO:0000250}.
Q9H790	reviewed	EXO5_HUMAN	Exonuclease V (Exo V) (hExo5) (EC 3.1.-.-) (Defects in morphology protein 1 homolog)	EXO5 C1orf176 DEM1	Homo sapiens (Human)	373	FUNCTION: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. {ECO:0000269|PubMed:23095756}.		interstrand cross-link repair [GO:0036297]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]; interstrand cross-link repair [GO:0036297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23095756}. Cytoplasm, cytosol {ECO:0000269|PubMed:23095756}. Note=Localizes to repair foci in response to DNA damage.
Q9H792	reviewed	PEAK1_HUMAN	Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)	PEAK1 KIAA2002	Homo sapiens (Human)	1746	FUNCTION: Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:23105102, PubMed:20534451, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}.		cell migration [GO:0016477]; focal adhesion assembly [GO:0048041]; protein autophosphorylation [GO:0046777]; regulation of focal adhesion assembly [GO:0051893]; substrate adhesion-dependent cell spreading [GO:0034446]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]	identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; cell migration [GO:0016477]; focal adhesion assembly [GO:0048041]; protein autophosphorylation [GO:0046777]; regulation of focal adhesion assembly [GO:0051893]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102}. Cell junction, focal adhesion {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:35687021}. Note=Colocalizes with F-actin in serum-rich medium (PubMed:20534451). Actin colocalization is reduced during serum starvation (PubMed:20534451). {ECO:0000269|PubMed:20534451}.
Q9H799	reviewed	CPLN1_HUMAN	Ciliogenesis and planar polarity effector 1 (Protein JBTS17)	CPLANE1 C5orf42 JBTS17	Homo sapiens (Human)	3197	FUNCTION: Involved in ciliogenesis (PubMed:25877302). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity). {ECO:0000250|UniProtKB:Q8CE72, ECO:0000305|PubMed:25877302}.		cilium assembly [GO:0060271]	ciliary transition zone [GO:0035869]; membrane [GO:0016020]		ciliary transition zone [GO:0035869]; membrane [GO:0016020]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8CE72}. Note=Localizes to the ciliary transition zone. {ECO:0000250|UniProtKB:Q8CE72}.
Q9H7B2	reviewed	RPF2_HUMAN	Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog)	RPF2 BXDC1	Homo sapiens (Human)	306	FUNCTION: Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. {ECO:0000269|PubMed:24120868}.		maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; protein localization to nucleolus [GO:1902570]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; protein localization to nucleolus [GO:1902570]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:19170763}. Note=Associated with the nucleolus in an RNA-dependent manner.
Q9H7B4	reviewed	SMYD3_HUMAN	Histone-lysine N-methyltransferase SMYD3 (EC 2.1.1.354) (SET and MYND domain-containing protein 3) (Zinc finger MYND domain-containing protein 1)	SMYD3 ZMYND1 ZNFN3A1	Homo sapiens (Human)	428	FUNCTION: Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609). {ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:22419068}.		cellular response to dexamethasone stimulus [GO:0071549]; establishment of protein localization [GO:0045184]; methylation [GO:0032259]; myotube cell development [GO:0014904]; nucleosome assembly [GO:0006334]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone H4 methyltransferase activity [GO:0140939]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone H4 methyltransferase activity [GO:0140939]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; cellular response to dexamethasone stimulus [GO:0071549]; establishment of protein localization [GO:0045184]; methylation [GO:0032259]; myotube cell development [GO:0014904]; nucleosome assembly [GO:0006334]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15235609}. Nucleus {ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:25738358}. Note=Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M. {ECO:0000269|PubMed:15235609}.
Q9H7C4	reviewed	SYNCI_HUMAN	Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1)	SYNC SYNC1	Homo sapiens (Human)	482	FUNCTION: Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. {ECO:0000250|UniProtKB:Q9EPM5}.		intermediate filament-based process [GO:0045103]	cytosol [GO:0005829]; intermediate filament [GO:0005882]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; sarcolemma [GO:0042383]; Z disc [GO:0030018]		cytosol [GO:0005829]; intermediate filament [GO:0005882]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; sarcolemma [GO:0042383]; Z disc [GO:0030018]; intermediate filament-based process [GO:0045103]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9EPM5}. Note=In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern (By similarity). {ECO:0000250|UniProtKB:Q9EPM5}.
Q9H7D0	reviewed	DOCK5_HUMAN	Dedicator of cytokinesis protein 5	DOCK5	Homo sapiens (Human)	1870	FUNCTION: Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}.		bone remodeling [GO:0046849]; cell migration [GO:0016477]; myoblast fusion [GO:0007520]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; podosome assembly [GO:0071800]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; Rac protein signal transduction [GO:0016601]	anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; podosome [GO:0002102]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; podosome [GO:0002102]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; bone remodeling [GO:0046849]; cell migration [GO:0016477]; myoblast fusion [GO:0007520]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; podosome assembly [GO:0071800]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; Rac protein signal transduction [GO:0016601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19004829}. Cell membrane {ECO:0000269|PubMed:19004829}. Cell projection, podosome {ECO:0000250|UniProtKB:B2RY04}. Note=Associated with the edge of the plasma membrane in Caco-2 intestinal epithelial cells spreading on type IV collagen. {ECO:0000269|PubMed:19004829}.
Q9H7D7	reviewed	WDR26_HUMAN	WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2)	WDR26 CDW2 MIP2 PRO0852	Homo sapiens (Human)	661	FUNCTION: G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity). {ECO:0000250|UniProtKB:F1LTR1, ECO:0000269|PubMed:15378603, ECO:0000269|PubMed:19446606, ECO:0000269|PubMed:23625927, ECO:0000269|PubMed:26895380, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:29911972}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GID complex [GO:0034657]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; GID complex [GO:0034657]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15378603}. Nucleus {ECO:0000269|PubMed:29911972}. Mitochondrion {ECO:0000250|UniProtKB:F1LTR1}.
Q9H7E2	reviewed	TDRD3_HUMAN	Tudor domain-containing protein 3	TDRD3	Homo sapiens (Human)	651	FUNCTION: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins (PubMed:15955813). Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci (PubMed:21172665). In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 (PubMed:35085371). {ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:21172665, ECO:0000269|PubMed:35085371}.		chromatin organization [GO:0006325]; DNA topological change [GO:0006265]	cytosol [GO:0005829]; DNA topoisomerase III-beta-TDRD3 complex [GO:0140225]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; DNA topoisomerase III-beta-TDRD3 complex [GO:0140225]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; chromatin organization [GO:0006325]; DNA topological change [GO:0006265]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18632687}. Nucleus {ECO:0000269|PubMed:21172665}. Note=Predominantly cytoplasmic. Associated with actively translating polyribosomes. Component of stress granules (PubMed:18664458, PubMed:35085371). {ECO:0000269|PubMed:18664458, ECO:0000269|PubMed:35085371}.
Q9H7E9	reviewed	CH033_HUMAN	UPF0488 protein C8orf33	C8orf33	Homo sapiens (Human)	229							
Q9H7F0	reviewed	AT133_HUMAN	Polyamine-transporting ATPase 13A3 (ATPase family homolog up-regulated in senescence cells 1) (Putrescine transporting ATPase) (EC 7.6.2.16)	ATP13A3 AFURS1	Homo sapiens (Human)	1226	FUNCTION: ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol. {ECO:0000269|PubMed:27429841, ECO:0000269|PubMed:33310703}.	MISCELLANEOUS: [Isoform 2]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.	intracellular calcium ion homeostasis [GO:0006874]; polyamine transmembrane transport [GO:1902047]	early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038]	ABC-type putrescine transporter activity [GO:0015594]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; P-type transmembrane transporter activity [GO:0140358]; polyamine transmembrane transporter activity [GO:0015203]	early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038]; ABC-type putrescine transporter activity [GO:0015594]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; P-type transmembrane transporter activity [GO:0140358]; polyamine transmembrane transporter activity [GO:0015203]; intracellular calcium ion homeostasis [GO:0006874]; polyamine transmembrane transport [GO:1902047]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:29505581}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:29505581}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:29505581}; Multi-pass membrane protein {ECO:0000255}. Note=Mainly targeted to the recycling endosomes and to a lesser extent to the early and late endosomes. {ECO:0000269|PubMed:29505581}.
Q9H7H0	reviewed	MET17_HUMAN	Methyltransferase-like protein 17, mitochondrial (EC 2.1.1.-) (False p73 target gene protein) (Methyltransferase 11 domain-containing protein 1) (Protein RSM22 homolog, mitochondrial)	METTL17 METT11D1	Homo sapiens (Human)	456	FUNCTION: Probable S-adenosyl-L-methionine-dependent RNA methyltransferase required to stabilize the mitochondrial small ribosomal subunit (mt-SSU). Required for protein translation in mitochondria. {ECO:0000250|UniProtKB:Q3U2U7}.		methylation [GO:0032259]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]	S-adenosyl-L-methionine binding [GO:1904047]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; S-adenosyl-L-methionine binding [GO:1904047]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; methylation [GO:0032259]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q3U2U7}.
Q9H7L9	reviewed	SDS3_HUMAN	Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)	SUDS3 SAP45 SDS3	Homo sapiens (Human)	328	FUNCTION: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:21239494}.		apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; substantia nigra development [GO:0021762]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; Sin3-type complex [GO:0070822]	enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; Sin3-type complex [GO:0070822]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21239494}.
Q9H7M9	reviewed	VISTA_HUMAN	V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor)	VSIR C10orf54 SISP1 VISTA PP2135 UNQ730/PRO1412	Homo sapiens (Human)	311	FUNCTION: Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}.		negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000565]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of cell migration [GO:0030335]; positive regulation of collagen catabolic process [GO:0120158]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of gene expression [GO:0010628]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of immune response [GO:0050776]; zymogen activation [GO:0031638]	plasma membrane [GO:0005886]	endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]	plasma membrane [GO:0005886]; endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000565]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of cell migration [GO:0030335]; positive regulation of collagen catabolic process [GO:0120158]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of gene expression [GO:0010628]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of immune response [GO:0050776]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}; Single-pass type I membrane protein {ECO:0000255}.
Q9H7N4	reviewed	SFR19_HUMAN	Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1)	SCAF1 SFRS19 SRA1	Homo sapiens (Human)	1312	FUNCTION: May function in pre-mRNA splicing. {ECO:0000250}.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; transcription by RNA polymerase II [GO:0006366]	nucleus [GO:0005634]	protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA polymerase II C-terminal domain binding [GO:0099122]	nucleus [GO:0005634]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA polymerase II C-terminal domain binding [GO:0099122]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H7P6	reviewed	MB12B_HUMAN	Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B)	MVB12B C9orf28 FAM125B	Homo sapiens (Human)	319	FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.		membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport [GO:0015031]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; virus maturation [GO:0019075]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	lipid binding [GO:0008289]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; lipid binding [GO:0008289]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport [GO:0015031]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; virus maturation [GO:0019075]	SUBCELLULAR LOCATION: Endosome {ECO:0000305}. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Q9H7P9	reviewed	PKHG2_HUMAN	Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2)	PLEKHG2	Homo sapiens (Human)	1386	FUNCTION: May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}.		regulation of actin filament polymerization [GO:0030833]	cytosol [GO:0005829]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; regulation of actin filament polymerization [GO:0030833]	
Q9H7S9	reviewed	ZN703_HUMAN	Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1)	ZNF703 ZEPPO1 ZPO1	Homo sapiens (Human)	590	FUNCTION: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}.		adherens junction assembly [GO:0034333]; cellular response to estradiol stimulus [GO:0071392]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of homotypic cell-cell adhesion [GO:0034111]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; adherens junction assembly [GO:0034333]; cellular response to estradiol stimulus [GO:0071392]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of homotypic cell-cell adhesion [GO:0034111]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}. Cytoplasm {ECO:0000250}.
Q9H7T9	reviewed	AUNIP_HUMAN	Aurora kinase A- and ninein-interacting protein (AIBp)	AUNIP C1orf135	Homo sapiens (Human)	357	FUNCTION: DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561). Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561). Inhibits non-homologous end joining (NHEJ) (PubMed:29042561). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670). {ECO:0000269|PubMed:20596670, ECO:0000269|PubMed:29042561}.		double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; spindle organization [GO:0007051]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; spindle pole [GO:0000922]	damaged DNA binding [GO:0003684]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; spindle pole [GO:0000922]; damaged DNA binding [GO:0003684]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29042561}. Chromosome {ECO:0000269|PubMed:29042561}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20596670}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20596670}. Note=Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replication forks (PubMed:29042561). Localizes to the centrosome in interphase and to the spindle pole in metaphase (PubMed:20596670). {ECO:0000269|PubMed:20596670, ECO:0000269|PubMed:29042561}.
Q9H7V2	reviewed	SYNG1_HUMAN	Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B)	SYNDIG1 C20orf39 TMEM90B	Homo sapiens (Human)	258	FUNCTION: May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation. {ECO:0000250}.		intracellular protein transport [GO:0006886]; positive regulation of synapse assembly [GO:0051965]; synaptic vesicle clustering [GO:0097091]	cell body [GO:0044297]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; excitatory synapse [GO:0060076]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672]	glutamate receptor binding [GO:0035254]; protein homodimerization activity [GO:0042803]	cell body [GO:0044297]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; excitatory synapse [GO:0060076]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672]; glutamate receptor binding [GO:0035254]; protein homodimerization activity [GO:0042803]; intracellular protein transport [GO:0006886]; positive regulation of synapse assembly [GO:0051965]; synaptic vesicle clustering [GO:0097091]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Early endosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Postsynaptic density membrane {ECO:0000250}. Synapse {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Shuttles between the cell surface and early endosome membrane. {ECO:0000250}.
Q9H7X0	reviewed	NAA60_HUMAN	N-alpha-acetyltransferase 60 (hNaa60) (EC 2.3.1.259) (Histone acetyltransferase type B protein 4) (HAT4) (EC 2.3.1.48) (N-acetyltransferase 15) (N-alpha-acetyltransferase F) (NatF)	NAA60 HAT4 NAT15 UNQ2771/PRO7155	Homo sapiens (Human)	242	FUNCTION: N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917). {ECO:0000269|PubMed:21750686, ECO:0000269|PubMed:25732826, ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639, ECO:0000305|PubMed:21981917}.	MISCELLANEOUS: [Isoform 2]: In placenta and leukocytes, expressed from the maternal allele, due to imprinting of the paternal allele. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing. {ECO:0000305}.	cell population proliferation [GO:0008283]; chromosome segregation [GO:0007059]; N-terminal peptidyl-methionine acetylation [GO:0017196]; N-terminal protein amino acid acetylation [GO:0006474]; nucleosome assembly [GO:0006334]	Golgi membrane [GO:0000139]	histone acetyltransferase activity [GO:0004402]; histone H4 acetyltransferase activity [GO:0010485]; peptide alpha-N-acetyltransferase activity [GO:0004596]; protein homodimerization activity [GO:0042803]	Golgi membrane [GO:0000139]; histone acetyltransferase activity [GO:0004402]; histone H4 acetyltransferase activity [GO:0010485]; peptide alpha-N-acetyltransferase activity [GO:0004596]; protein homodimerization activity [GO:0042803]; cell population proliferation [GO:0008283]; chromosome segregation [GO:0007059]; N-terminal peptidyl-methionine acetylation [GO:0017196]; N-terminal protein amino acid acetylation [GO:0006474]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:21981917, ECO:0000269|PubMed:25732826}; Peripheral membrane protein {ECO:0000269|PubMed:25732826}; Cytoplasmic side {ECO:0000269|PubMed:25732826}. Note=Probably forms an intramembrane hairpin-like structure in the membrane. {ECO:0000305|PubMed:25732826}.
Q9H7X3	reviewed	ZN696_HUMAN	Zinc finger protein 696	ZNF696	Homo sapiens (Human)	374	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H7Z3	reviewed	NRDE2_HUMAN	Nuclear exosome regulator NRDE2 (Protein NRDE2 homolog)	NRDE2 C14orf102	Homo sapiens (Human)	1164	FUNCTION: Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217). U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (PubMed:30538148). Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (PubMed:30538148). Plays a role in DNA damage response (PubMed:29902117). {ECO:0000269|PubMed:29902117, ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30842217}.		cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic cell cycle [GO:0000278]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of RNA catabolic process [GO:1902369]; positive regulation of RNA export from nucleus [GO:0046833]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; RNA splicing [GO:0008380]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic cell cycle [GO:0000278]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of RNA catabolic process [GO:1902369]; positive regulation of RNA export from nucleus [GO:0046833]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30842217}. Nucleus, nucleolus {ECO:0000269|PubMed:30842217}. Nucleus, nucleoplasm {ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30842217}. Nucleus {ECO:0000269|PubMed:29902117}.
Q9H7Z6	reviewed	KAT8_HUMAN	Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF)	KAT8 MOF MYST1 PP7073	Homo sapiens (Human)	458	FUNCTION: Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126). May influence the function of ATM (PubMed:15923642). As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026). That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026). Can also acetylate TP53/p53 at 'Lys-120'. {ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:15923642, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:31794431}.		myeloid cell differentiation [GO:0030099]; negative regulation of DNA-templated transcription [GO:0045892]; neurogenesis [GO:0022008]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of autophagy [GO:0010506]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; MLL1 complex [GO:0071339]; MSL complex [GO:0072487]; NSL complex [GO:0044545]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	enzyme binding [GO:0019899]; histone H4K16 acetyltransferase activity [GO:0046972]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; MLL1 complex [GO:0071339]; MSL complex [GO:0072487]; NSL complex [GO:0044545]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; histone H4K16 acetyltransferase activity [GO:0046972]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; myeloid cell differentiation [GO:0030099]; negative regulation of DNA-templated transcription [GO:0045892]; neurogenesis [GO:0022008]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of autophagy [GO:0010506]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10786633, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:31794431}. Chromosome {ECO:0000305|PubMed:10786633}.
Q9H7Z7	reviewed	PGES2_HUMAN	Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form]	PTGES2 C9orf15 PGES2	Homo sapiens (Human)	377	FUNCTION: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:18198127, PubMed:17585783). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:18198127, PubMed:17585783). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:17585783) (By similarity). {ECO:0000250|UniProtKB:Q9N0A4, ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:17585783, ECO:0000269|PubMed:18198127}.		cyclooxygenase pathway [GO:0019371]; lipid metabolic process [GO:0006629]; positive regulation of DNA-templated transcription [GO:0045893]; secretion [GO:0046903]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	12-hydroxyheptadecatrienoic acid synthase activity [GO:0036134]; DNA binding [GO:0003677]; glutathione binding [GO:0043295]; heme binding [GO:0020037]; lyase activity [GO:0016829]; prostaglandin-E synthase activity [GO:0050220]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; 12-hydroxyheptadecatrienoic acid synthase activity [GO:0036134]; DNA binding [GO:0003677]; glutathione binding [GO:0043295]; heme binding [GO:0020037]; lyase activity [GO:0016829]; prostaglandin-E synthase activity [GO:0050220]; cyclooxygenase pathway [GO:0019371]; lipid metabolic process [GO:0006629]; positive regulation of DNA-templated transcription [GO:0045893]; secretion [GO:0046903]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12835322}; Single-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Prostaglandin E synthase 2 truncated form]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12835322}. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region. {ECO:0000269|PubMed:12835322}.
Q9H808	reviewed	TLE6_HUMAN	Transducin-like enhancer protein 6	TLE6	Homo sapiens (Human)	572	FUNCTION: Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (By similarity). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (By similarity). Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (By similarity). {ECO:0000250|UniProtKB:Q9WVB3}.; FUNCTION: [Isoform 1]: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:26537248). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). {ECO:0000250|UniProtKB:Q9WVB3, ECO:0000269|PubMed:26537248}.		actin filament organization [GO:0007015]; embryonic process involved in female pregnancy [GO:0060136]; endoplasmic reticulum localization [GO:0051643]; establishment of spindle localization [GO:0051293]; mitochondrion localization [GO:0051646]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of embryonic development [GO:0040019]; regulation of cell division [GO:0051302]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; subcortical maternal complex [GO:0106333]; transcription regulator complex [GO:0005667]	transcription corepressor activity [GO:0003714]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; subcortical maternal complex [GO:0106333]; transcription regulator complex [GO:0005667]; transcription corepressor activity [GO:0003714]; actin filament organization [GO:0007015]; embryonic process involved in female pregnancy [GO:0060136]; endoplasmic reticulum localization [GO:0051643]; establishment of spindle localization [GO:0051293]; mitochondrion localization [GO:0051646]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of embryonic development [GO:0040019]; regulation of cell division [GO:0051302]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9WVB3}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:25542835}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:25542835}.
Q9H813	reviewed	PACC1_HUMAN	Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206)	PACC1 C1orf75 TMEM206	Homo sapiens (Human)	350	FUNCTION: Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925, PubMed:31318332). {ECO:0000269|PubMed:31023925, ECO:0000269|PubMed:31318332}.		chloride transport [GO:0006821]	cell surface [GO:0009986]; chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]	pH-gated chloride channel activity [GO:0061797]	cell surface [GO:0009986]; chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]; pH-gated chloride channel activity [GO:0061797]; chloride transport [GO:0006821]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31023925, ECO:0000269|PubMed:31318332}; Multi-pass membrane protein {ECO:0000305}.
Q9H814	reviewed	PHAX_HUMAN	Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein)	PHAX RNUXA	Homo sapiens (Human)	394	FUNCTION: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}.		protein transport [GO:0015031]; RNA stabilization [GO:0043489]; snRNA export from nucleus [GO:0006408]	Cajal body [GO:0015030]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA cap binding complex binding [GO:0140262]; RNA binding [GO:0003723]; toxic substance binding [GO:0015643]	Cajal body [GO:0015030]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA cap binding complex binding [GO:0140262]; RNA binding [GO:0003723]; toxic substance binding [GO:0015643]; protein transport [GO:0015031]; RNA stabilization [GO:0043489]; snRNA export from nucleus [GO:0006408]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:11333016, ECO:0000269|PubMed:15574332}. Nucleus, Cajal body {ECO:0000269|PubMed:15574332}. Cytoplasm {ECO:0000269|PubMed:11333016}. Note=Located in the nucleoplasm and Cajal bodies. Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies. {ECO:0000269|PubMed:11333016, ECO:0000269|PubMed:15574332}.
Q9H816	reviewed	DCR1B_HUMAN	5' exonuclease Apollo (EC 3.1.-.-) (Beta-lactamase DCLRE1B) (EC 3.5.2.6) (DNA cross-link repair 1B protein) (SNM1 homolog B) (SNMIB) (hSNM1B)	DCLRE1B SNM1B	Homo sapiens (Human)	532	FUNCTION: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). {ECO:0000269|PubMed:15467758, ECO:0000269|PubMed:15572677, ECO:0000269|PubMed:16730175, ECO:0000269|PubMed:16730176, ECO:0000269|PubMed:18468965, ECO:0000269|PubMed:18469862, ECO:0000269|PubMed:19197158, ECO:0000269|PubMed:19411856, ECO:0000269|PubMed:20655466, ECO:0000269|PubMed:31434986}.	MISCELLANEOUS: Was named 'Apollo' in reference to the twin brother of 'Artemis' in Greek mythology (PubMed:16730175, PubMed:16730176). Artemis/DCLRE1C is a related nuclease.	double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297]; protection from non-homologous end joining at telomere [GO:0031848]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]; telomeric 3' overhang formation [GO:0031860]; telomeric loop formation [GO:0031627]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	5'-3' DNA exonuclease activity [GO:0035312]; 5'-3' exonuclease activity [GO:0008409]; beta-lactamase activity [GO:0008800]; damaged DNA binding [GO:0003684]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; 5'-3' DNA exonuclease activity [GO:0035312]; 5'-3' exonuclease activity [GO:0008409]; beta-lactamase activity [GO:0008800]; damaged DNA binding [GO:0003684]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297]; protection from non-homologous end joining at telomere [GO:0031848]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]; telomeric 3' overhang formation [GO:0031860]; telomeric loop formation [GO:0031627]	SUBCELLULAR LOCATION: Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome.
Q9H825	reviewed	METL8_HUMAN	tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial (EC 2.1.1.-) (Methyltransferase-like protein 8) (mRNA N(3)-methylcytidine methyltransferase METTL8) (EC 2.1.1.-)	METTL8	Homo sapiens (Human)	291	FUNCTION: Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr) (PubMed:34774131, PubMed:35017528). N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain (PubMed:34774131, PubMed:35017528). N(3)-methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite (PubMed:34774131, PubMed:35017528). May also mediate N(3)-methylcytidine modification of mRNAs (PubMed:28655767). The existence of N(3)-methylcytidine modification on mRNAs is however unclear, and additional evidences are required to confirm the role of the N(3)-methylcytidine-specific mRNA methyltransferase activity of METTL8 in vivo (PubMed:34774131, PubMed:33313824). {ECO:0000269|PubMed:28655767, ECO:0000269|PubMed:33313824, ECO:0000269|PubMed:34774131, ECO:0000269|PubMed:35017528}.		mitochondrial tRNA modification [GO:0070900]; mRNA methylation [GO:0080009]; positive regulation of mitochondrial translation [GO:0070131]; tRNA C3-cytosine methylation [GO:0106217]	mitochondrion [GO:0005739]	mRNA methyltransferase activity [GO:0008174]; tRNA (cytosine-3-)-methyltransferase activity [GO:0052735]	mitochondrion [GO:0005739]; mRNA methyltransferase activity [GO:0008174]; tRNA (cytosine-3-)-methyltransferase activity [GO:0052735]; mitochondrial tRNA modification [GO:0070900]; mRNA methylation [GO:0080009]; positive regulation of mitochondrial translation [GO:0070131]; tRNA C3-cytosine methylation [GO:0106217]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:34774131, ECO:0000269|PubMed:35017528}. Note=Mitochondrial protein: the cytoplasmic or nuclear localization observed by some groups is either the result of an incorrect localization caused by N-terminal tagging that interferes with mitochondrial targeting, or splice isoforms that lack the N-terminal mitochondrial transit sequence. {ECO:0000269|PubMed:34774131}.
Q9H832	reviewed	UBE2Z_HUMAN	Ubiquitin-conjugating enzyme E2 Z (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Z) (Uba6-specific E2 conjugating enzyme 1) (Use1) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z)	UBE2Z HOYS7	Homo sapiens (Human)	354	FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. {ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000269|PubMed:17464193, ECO:0000269|PubMed:17597759}.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; molecular adaptor activity [GO:0060090]; ubiquitin conjugating enzyme activity [GO:0061631]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; molecular adaptor activity [GO:0060090]; ubiquitin conjugating enzyme activity [GO:0061631]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17160626}. Nucleus {ECO:0000269|PubMed:17160626}.
Q9H840	reviewed	GEMI7_HUMAN	Gem-associated protein 7 (Gemin-7) (SIP3)	GEMIN7	Homo sapiens (Human)	131	FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:12065586, ECO:0000269|PubMed:18984161}.		mRNA splicing, via spliceosome [GO:0000398]; spliceosomal snRNP assembly [GO:0000387]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; Sm-like protein family complex [GO:0120114]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; Sm-like protein family complex [GO:0120114]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:12065586}. Nucleus, gem {ECO:0000269|PubMed:12065586}. Cytoplasm {ECO:0000269|PubMed:12065586}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Q9H845	reviewed	ACAD9_HUMAN	Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-)	ACAD9	Homo sapiens (Human)	621	FUNCTION: As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation (PubMed:20816094, PubMed:24158852, PubMed:32320651). This moonlighting protein has also a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation (PubMed:20816094, PubMed:24158852). In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein (PubMed:24158852). {ECO:0000269|PubMed:12359260, ECO:0000269|PubMed:16020546, ECO:0000269|PubMed:20816094, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:24158852, ECO:0000269|PubMed:32320651}.		long-chain fatty acid metabolic process [GO:0001676]; medium-chain fatty acid metabolic process [GO:0051791]; mitochondrial respiratory chain complex I assembly [GO:0032981]	dendrite [GO:0030425]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; long-chain-acyl-CoA dehydrogenase activity [GO:0004466]; medium-chain-acyl-CoA dehydrogenase activity [GO:0070991]	dendrite [GO:0030425]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; long-chain-acyl-CoA dehydrogenase activity [GO:0004466]; medium-chain-acyl-CoA dehydrogenase activity [GO:0070991]; long-chain fatty acid metabolic process [GO:0001676]; medium-chain fatty acid metabolic process [GO:0051791]; mitochondrial respiratory chain complex I assembly [GO:0032981]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16020546, ECO:0000269|PubMed:20816094}; Peripheral membrane protein {ECO:0000269|PubMed:16020546}; Matrix side {ECO:0000269|PubMed:16020546}. Note=Essentially associated with membranes. {ECO:0000269|PubMed:16020546}.
Q9H867	reviewed	MT21D_HUMAN	Protein N-lysine methyltransferase METTL21D (EC 2.1.1.-) (Methyltransferase-like protein 21D) (VCP lysine methyltransferase) (VCP-KMT) (Valosin-containing protein lysine methyltransferase)	VCPKMT C14orf138 METTL21D	Homo sapiens (Human)	229	FUNCTION: Protein N-lysine methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity. {ECO:0000269|PubMed:22948820, ECO:0000269|PubMed:23349634}.		negative regulation of ATP-dependent activity [GO:0032780]; peptidyl-lysine methylation [GO:0018022]; peptidyl-lysine trimethylation [GO:0018023]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]	ATPase binding [GO:0051117]; histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; ATPase binding [GO:0051117]; histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279]; negative regulation of ATP-dependent activity [GO:0032780]; peptidyl-lysine methylation [GO:0018022]; peptidyl-lysine trimethylation [GO:0018023]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23349634}.
Q9H869	reviewed	YYAP1_HUMAN	YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2)	YY1AP1 HCCA2 YY1AP	Homo sapiens (Human)	796	FUNCTION: Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}.		cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coregulator activity [GO:0003712]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coregulator activity [GO:0003712]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11710830, ECO:0000269|PubMed:12118372}. Nucleus {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814}. Nucleus, nucleoplasm {ECO:0000269|PubMed:27939641}. Nucleus, nucleolus {ECO:0000269|PubMed:27939641}.
Q9H871	reviewed	RMD5A_HUMAN	E3 ubiquitin-protein transferase RMND5A (EC 2.3.2.27) (P44CTLH) (Protein RMD5 homolog A)	RMND5A	Homo sapiens (Human)	391	FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). {ECO:0000269|PubMed:29911972}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]	cytoplasm [GO:0005737]; GID complex [GO:0034657]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; GID complex [GO:0034657]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:25793641}. Cytoplasm {ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:25793641}.
Q9H875	reviewed	PKRI1_HUMAN	PRKR-interacting protein 1	PRKRIP1	Homo sapiens (Human)	184	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:30705154). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity). {ECO:0000250|UniProtKB:Q9CWV6, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}.		mRNA processing [GO:0006397]; negative regulation of phosphorylation [GO:0042326]; negative regulation of protein kinase activity [GO:0006469]; renal system process [GO:0003014]; RNA splicing [GO:0008380]	extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]	double-stranded RNA binding [GO:0003725]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]	extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; double-stranded RNA binding [GO:0003725]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; mRNA processing [GO:0006397]; negative regulation of phosphorylation [GO:0042326]; negative regulation of protein kinase activity [GO:0006469]; renal system process [GO:0003014]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9CWV6}.
Q9H892	reviewed	TTC12_HUMAN	Tetratricopeptide repeat protein 12 (TPR repeat protein 12)	TTC12	Homo sapiens (Human)	705	FUNCTION: Cytoplasmic protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both respiratory cells and sperm flagella. {ECO:0000269|PubMed:31978331}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	axonemal dynein complex assembly [GO:0070286]; sperm axoneme assembly [GO:0007288]	centrosome [GO:0005813]; cytoplasm [GO:0005737]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; axonemal dynein complex assembly [GO:0070286]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31978331}.
Q9H8E8	reviewed	CSR2B_HUMAN	Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) (Lysine acetyltransferase 14)	KAT14 CSRP2BP	Homo sapiens (Human)	782	FUNCTION: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. {ECO:0000269|PubMed:19103755}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	ATAC complex [GO:0140672]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone acetyltransferase activity [GO:0004402]; LIM domain binding [GO:0030274]	ATAC complex [GO:0140672]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone acetyltransferase activity [GO:0004402]; LIM domain binding [GO:0030274]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Mainly nuclear.
Q9H8H2	reviewed	DDX31_HUMAN	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.4.13) (DEAD box protein 31) (Helicain)	DDX31	Homo sapiens (Human)	851	FUNCTION: Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (PubMed:23019224). {ECO:0000250, ECO:0000269|PubMed:23019224}.		ribosome biogenesis [GO:0042254]	Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:23019224}. Note=Colocalized with NPM1 in the nucleoli. {ECO:0000269|PubMed:23019224}.
Q9H8H3	reviewed	TMT1A_HUMAN	N6-adenosine-methyltransferase TMT1A (EC 2.1.1.348) (Methyltransferase TMT1A) (Methyltransferase-like protein 7A) (Protein AAM-B) (Thiol methyltransferase 1A)	TMT1A METTL7A PRO0066 UNQ1902/PRO4348	Homo sapiens (Human)	244	FUNCTION: N(6)-adenine-methyltransferase able to methylate both DNA and long non-coding RNAs. Methylates adenosine residues at the N6 position of some long non-coding RNAs (lncRNAs) (PubMed:34980213). DNA methylation by TMT1A promote osteogenic and odontogenic differentiation by upregulating expression of genes that promote differentiation and survival (PubMed:34226523, PubMed:34790668). Recruits cellular proteins to the lipid droplet for the formation of functional organelles (PubMed:19773358). Acts also as an oncogene in multiple myeloma (PubMed:34790668). {ECO:0000269|PubMed:19773358, ECO:0000269|PubMed:34226523, ECO:0000269|PubMed:34790668, ECO:0000269|PubMed:34980213}.; FUNCTION: (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation. {ECO:0000269|PubMed:26185986}.		DNA methylation [GO:0006306]; mRNA methylation [GO:0080009]; odontogenesis [GO:0042476]; osteoblast differentiation [GO:0001649]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; tertiary granule lumen [GO:1904724]	methyltransferase activity [GO:0008168]; mRNA (N6-adenosine)-methyltransferase activity [GO:0001734]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; tertiary granule lumen [GO:1904724]; methyltransferase activity [GO:0008168]; mRNA (N6-adenosine)-methyltransferase activity [GO:0001734]; DNA methylation [GO:0006306]; mRNA methylation [GO:0080009]; odontogenesis [GO:0042476]; osteoblast differentiation [GO:0001649]	SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:18477614, ECO:0000269|PubMed:19773358, ECO:0000269|PubMed:26185986}. Endoplasmic reticulum {ECO:0000269|PubMed:19773358}. Membrane {ECO:0000269|PubMed:18477614}. Note=Inserted in the ER membrane and migrates from the inserted site to lipid droplet. {ECO:0000269|PubMed:18477614}.
Q9H8K7	reviewed	PAAT_HUMAN	ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT)	PAAT C10orf88	Homo sapiens (Human)	445	FUNCTION: ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). {ECO:0000269|PubMed:25063848}.			cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25063848}. Mitochondrion {ECO:0000269|PubMed:25063848}.
Q9H8L6	reviewed	MMRN2_HUMAN	Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit)	MMRN2 EMILIN3	Homo sapiens (Human)	949	FUNCTION: Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it down-regulates KDR activation by binding VEGFA. {ECO:0000269|PubMed:22020326}.		cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration [GO:0030336]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of morphogenesis of an epithelium [GO:1905332]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; multimerin complex [GO:1990972]		basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; multimerin complex [GO:1990972]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration [GO:0030336]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of morphogenesis of an epithelium [GO:1905332]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11559704}.
Q9H8M2	reviewed	BRD9_HUMAN	Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8)	BRD9 UNQ3040/PRO9856	Homo sapiens (Human)	597	FUNCTION: Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Orchestrates also the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). {ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:32457312}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]	lysine-acetylated histone binding [GO:0070577]; nucleic acid binding [GO:0003676]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]; lysine-acetylated histone binding [GO:0070577]; nucleic acid binding [GO:0003676]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309}.
Q9H8M5	reviewed	CNNM2_HUMAN	Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2)	CNNM2 ACDP2	Homo sapiens (Human)	875	FUNCTION: Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). {ECO:0000250|UniProtKB:Q3TWN3}.	MISCELLANEOUS: Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.	magnesium ion homeostasis [GO:0010960]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; magnesium ion transmembrane transporter activity [GO:0015095]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; magnesium ion transmembrane transporter activity [GO:0015095]; magnesium ion homeostasis [GO:0010960]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9H8M7	reviewed	MINY3_HUMAN	Ubiquitin carboxyl-terminal hydrolase MINDY-3 (EC 3.4.19.12) (Dermal papilla-derived protein 5) (Deubiquitinating enzyme MINDY-3) (Protein CARP)	MINDY3 C10orf97 CARP DERP5 FAM188A MSTP126 My042	Homo sapiens (Human)	445	FUNCTION: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000269|PubMed:27292798}.		apoptotic process [GO:0006915]; proteolysis [GO:0006508]	nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]	cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]	nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; apoptotic process [GO:0006915]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12054670}.
Q9H8M9	reviewed	EVA1A_HUMAN	Protein eva-1 homolog A (Protein FAM176A) (Transmembrane protein 166)	EVA1A FAM176A TMEM166 SP24	Homo sapiens (Human)	152	FUNCTION: Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis. {ECO:0000269|PubMed:17492404, ECO:0000269|PubMed:19029833}.		apoptotic process [GO:0006915]; autophagy [GO:0006914]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]		endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; apoptotic process [GO:0006915]; autophagy [GO:0006914]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17492404}; Single-pass membrane protein {ECO:0000269|PubMed:17492404}. Lysosome membrane {ECO:0000269|PubMed:17492404}; Single-pass membrane protein {ECO:0000269|PubMed:17492404}.
Q9H8N7	reviewed	ZN395_HUMAN	Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor)	ZNF395 HDBP2 PBF	Homo sapiens (Human)	513	FUNCTION: Plays a role in papillomavirus genes transcription.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=May shuttle between nucleus and cytoplasm.
Q9H8P0	reviewed	PORED_HUMAN	Polyprenol reductase (EC 1.3.1.94) (3-oxo-5-alpha-steroid 4-dehydrogenase 3) (EC 1.3.1.22) (Steroid 5-alpha-reductase 2-like) (Steroid 5-alpha-reductase 3) (S5AR 3) (SR type 3)	SRD5A3 SRD5A2L	Homo sapiens (Human)	318	FUNCTION: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol (PubMed:20637498). Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (PubMed:20637498). Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (PubMed:20637498). Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (PubMed:17986282, PubMed:26855069). {ECO:0000269|PubMed:17986282, ECO:0000269|PubMed:20637498, ECO:0000269|PubMed:26855069}.		androgen biosynthetic process [GO:0006702]; dolichol biosynthetic process [GO:0019408]; dolichol metabolic process [GO:0019348]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; dolichyl diphosphate biosynthetic process [GO:0006489]; polyprenol catabolic process [GO:0016095]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	3-oxo-5-alpha-steroid 4-dehydrogenase activity [GO:0003865]; 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) [GO:0047751]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; polyprenol reductase activity [GO:0102389]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; 3-oxo-5-alpha-steroid 4-dehydrogenase activity [GO:0003865]; 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) [GO:0047751]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; polyprenol reductase activity [GO:0102389]; androgen biosynthetic process [GO:0006702]; dolichol biosynthetic process [GO:0019408]; dolichol metabolic process [GO:0019348]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; dolichyl diphosphate biosynthetic process [GO:0006489]; polyprenol catabolic process [GO:0016095]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:20637498}; Multi-pass membrane protein {ECO:0000305|PubMed:20637498}.
Q9H8S9	reviewed	MOB1A_HUMAN	MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B)	MOB1A C2orf6 MOB4B MOBK1B MOBKL1B	Homo sapiens (Human)	216	FUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	hippo signaling [GO:0035329]; positive regulation of protein phosphorylation [GO:0001934]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; hippo signaling [GO:0035329]; positive regulation of protein phosphorylation [GO:0001934]	
Q9H8T0	reviewed	AKTIP_HUMAN	AKT-interacting protein (Ft1) (Fused toes protein homolog)	AKTIP FTS	Homo sapiens (Human)	292	FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:14749367, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}.		apoptotic process [GO:0006915]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein neddylation [GO:0045116]; protein transport [GO:0015031]	cytosol [GO:0005829]; FHF complex [GO:0070695]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	NEDD8 transferase activity [GO:0019788]	cytosol [GO:0005829]; FHF complex [GO:0070695]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; NEDD8 transferase activity [GO:0019788]; apoptotic process [GO:0006915]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein neddylation [GO:0045116]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14749367}. Cell membrane {ECO:0000269|PubMed:14749367}; Peripheral membrane protein {ECO:0000269|PubMed:14749367}.
Q9H8V3	reviewed	ECT2_HUMAN	Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)	ECT2	Homo sapiens (Human)	914	FUNCTION: Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	activation of GTPase activity [GO:0090630]; activation of protein kinase activity [GO:0032147]; bicellular tight junction assembly [GO:0070830]; cell differentiation [GO:0030154]; cell morphogenesis [GO:0000902]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to ionizing radiation [GO:0071479]; intracellular signal transduction [GO:0035556]; mitotic cytokinesis [GO:0000281]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokinesis [GO:0032467]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein import into nucleus [GO:0042307]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of cytokinesis, actomyosin contractile ring assembly [GO:2000431]; regulation of protein kinase activity [GO:0045859]; regulation of small GTPase mediated signal transduction [GO:0051056]	bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; centralspindlin complex [GO:0097149]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]	bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; centralspindlin complex [GO:0097149]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; activation of GTPase activity [GO:0090630]; activation of protein kinase activity [GO:0032147]; bicellular tight junction assembly [GO:0070830]; cell differentiation [GO:0030154]; cell morphogenesis [GO:0000902]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to ionizing radiation [GO:0071479]; intracellular signal transduction [GO:0035556]; mitotic cytokinesis [GO:0000281]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokinesis [GO:0032467]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein import into nucleus [GO:0042307]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of cytokinesis, actomyosin contractile ring assembly [GO:2000431]; regulation of protein kinase activity [GO:0045859]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19617897}. Cytoplasm {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16394104}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:17115030, ECO:0000269|PubMed:19468300}. Cleavage furrow {ECO:0000269|PubMed:10579713}. Midbody {ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:16394104, ECO:0000269|PubMed:17115030}. Cell junction {ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:16495035}. Cell junction, tight junction {ECO:0000269|PubMed:15254234}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17115030}. Note=Sequestered within the nucleus during interphase (PubMed:10579713). Dispersed throughout the cytoplasm upon breakdown of the nuclear envelope during mitosis (PubMed:10579713). Colocalizes with the centralspindlin complex to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis (PubMed:10579713). Colocalized with RhoA at the midbody (PubMed:10579713). Its subcellular localization to tight junction is increased by calcium (PubMed:15254234). {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:15254234}.
Q9H8W4	reviewed	PKHF2_HUMAN	Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) (Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains) (EAPF) (PH and FYVE domain-containing protein 2) (Phafin-2) (Phafin2) (Zinc finger FYVE domain-containing protein 18)	PLEKHF2 ZFYVE18	Homo sapiens (Human)	249	FUNCTION: May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}.		endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; protein transport [GO:0015031]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; transport vesicle [GO:0030133]	metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; transport vesicle [GO:0030133]; metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}; Peripheral membrane protein {ECO:0000305|PubMed:19995552, ECO:0000305|PubMed:22816767}. Endoplasmic reticulum {ECO:0000269|PubMed:18288467}. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots (PubMed:19995552). May translocate to the endoplasmic reticulum in the early phase of apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552}.
Q9H8W5	reviewed	TRI45_HUMAN	E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99)	TRIM45 RNF99	Homo sapiens (Human)	580	FUNCTION: E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779). Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response (PubMed:36681779). May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. {ECO:0000269|PubMed:15351693, ECO:0000269|PubMed:36681779}.		bone development [GO:0060348]; negative regulation of inflammatory response [GO:0050728]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; bone development [GO:0060348]; negative regulation of inflammatory response [GO:0050728]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15351693, ECO:0000269|PubMed:36681779}. Nucleus {ECO:0000269|PubMed:15351693}.
Q9H8X2	reviewed	IPPK_HUMAN	Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (IPK1 homolog) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase)	IPPK C9orf12	Homo sapiens (Human)	491	FUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}.		inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; phosphorylation [GO:0016310]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; inositol pentakisphosphate 2-kinase activity [GO:0035299]; molecular adaptor activity [GO:0060090]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; inositol pentakisphosphate 2-kinase activity [GO:0035299]; molecular adaptor activity [GO:0060090]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; phosphorylation [GO:0016310]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q9H8X9	reviewed	ZDH11_HUMAN	Palmitoyltransferase ZDHHC11 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 11) (DHHC-11) (Zinc finger protein 399)	ZDHHC11 ZNF399	Homo sapiens (Human)	412	FUNCTION: Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (By similarity). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (By similarity). May play a role in cell proliferation (PubMed:28331227). {ECO:0000250|UniProtKB:Q14AK4, ECO:0000269|PubMed:28331227}.; FUNCTION: Has also a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response (PubMed:28331227). Functions as an adapter that recruits IRF3 to STING1 to promote the activation of that key transcriptional regulator of type I interferon (IFN)-dependent immune response (PubMed:28331227). {ECO:0000269|PubMed:28331227}.		antiviral innate immune response [GO:0140374]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of defense response to virus by host [GO:0002230]; protein targeting to membrane [GO:0006612]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	protein-cysteine S-palmitoyltransferase activity [GO:0019706]; signaling adaptor activity [GO:0035591]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; signaling adaptor activity [GO:0035591]; antiviral innate immune response [GO:0140374]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of defense response to virus by host [GO:0002230]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16647879}; Multi-pass membrane protein {ECO:0000255}.
Q9H8Y5	reviewed	ANKZ1_HUMAN	tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744)	ANKZF1 ZNF744	Homo sapiens (Human)	726	FUNCTION: Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:30244831, PubMed:29632312, PubMed:31011209). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:30244831, PubMed:29632312, PubMed:31011209). ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs (PubMed:31011209). ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 (PubMed:31011209, PubMed:32075755). Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). {ECO:0000269|PubMed:28302725, ECO:0000269|PubMed:29632312, ECO:0000269|PubMed:30244831, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:32075755}.		cellular response to hydrogen peroxide [GO:0070301]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasm [GO:0005737]; membrane [GO:0016020]	catalytic activity, acting on a tRNA [GO:0140101]; metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; membrane [GO:0016020]; catalytic activity, acting on a tRNA [GO:0140101]; metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]; cellular response to hydrogen peroxide [GO:0070301]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28302725}. Note=Translocates to the mitochondria upon exposure to hydrogen peroxide. {ECO:0000269|PubMed:28302725}.
Q9H8Y8	reviewed	GORS2_HUMAN	Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59)	GORASP2 GOLPH6	Homo sapiens (Human)	452	FUNCTION: Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}.		cell differentiation [GO:0030154]; establishment of protein localization to plasma membrane [GO:0061951]; Golgi organization [GO:0007030]; organelle assembly [GO:0070925]; organelle organization [GO:0006996]; response to endoplasmic reticulum stress [GO:0034976]; spermatogenesis [GO:0007283]	cis-Golgi network [GO:0005801]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]		cis-Golgi network [GO:0005801]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; cell differentiation [GO:0030154]; establishment of protein localization to plasma membrane [GO:0061951]; Golgi organization [GO:0007030]; organelle assembly [GO:0070925]; organelle organization [GO:0006996]; response to endoplasmic reticulum stress [GO:0034976]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:27062250}; Lipid-anchor {ECO:0000269|PubMed:11101516}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27062250}. Golgi apparatus {ECO:0000269|PubMed:28067262}. Note=Detected in the intermediate Golgi, membrane-associated (By similarity). ER stress triggers its relocalization from Golgi to ER membrane (PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q9R064, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}.
Q9H900	reviewed	ZWILC_HUMAN	Protein zwilch homolog (hZwilch)	ZWILCH	Homo sapiens (Human)	591	FUNCTION: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131). {ECO:0000269|PubMed:15824131}.	MISCELLANEOUS: ZWILCH gene is deleted in a patient suffering from colorectal cancer with chromosomal instability.	cell division [GO:0051301]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]	cytosol [GO:0005829]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; RZZ complex [GO:1990423]		cytosol [GO:0005829]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; RZZ complex [GO:1990423]; cell division [GO:0051301]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]	SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20462495}.
Q9H902	reviewed	REEP1_HUMAN	Receptor expression-enhancing protein 1 (Spastic paraplegia 31 protein)	REEP1 C2orf23 SPG31	Homo sapiens (Human)	201	FUNCTION: Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (PubMed:20200447). May play a role in long-term axonal maintenance (PubMed:24478229). {ECO:0000269|PubMed:20200447, ECO:0000269|PubMed:24478229}.		endoplasmic reticulum tubular network organization [GO:0071786]; protein insertion into membrane [GO:0051205]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]	microtubule binding [GO:0008017]; olfactory receptor binding [GO:0031849]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; microtubule binding [GO:0008017]; olfactory receptor binding [GO:0031849]; endoplasmic reticulum tubular network organization [GO:0071786]; protein insertion into membrane [GO:0051205]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:16826527}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:20200447}. Note=Localizes to endoplasmic reticulum tubular network. {ECO:0000269|PubMed:20200447}.
Q9H903	reviewed	MTD2L_HUMAN	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein) (MTHFD2-like) [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15) (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]	MTHFD2L	Homo sapiens (Human)	347	FUNCTION: Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. {ECO:0000250|UniProtKB:D3ZUA0}.		10-formyltetrahydrofolate metabolic process [GO:0009256]; folic acid metabolic process [GO:0046655]; histidine biosynthetic process [GO:0000105]; methionine biosynthetic process [GO:0009086]; purine nucleotide biosynthetic process [GO:0006164]; tetrahydrofolate interconversion [GO:0035999]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; 10-formyltetrahydrofolate metabolic process [GO:0009256]; folic acid metabolic process [GO:0046655]; histidine biosynthetic process [GO:0000105]; methionine biosynthetic process [GO:0009086]; purine nucleotide biosynthetic process [GO:0006164]; tetrahydrofolate interconversion [GO:0035999]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:D3ZUA0}; Peripheral membrane protein {ECO:0000250|UniProtKB:D3ZUA0}; Matrix side {ECO:0000250|UniProtKB:D3ZUA0}.
Q9H910	reviewed	JUPI2_HUMAN	Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein)	JPT2 C16orf34 HN1L L11	Homo sapiens (Human)	190	FUNCTION: Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}.		endocytosis involved in viral entry into host cell [GO:0075509]; regulation of calcium-mediated signaling [GO:0050848]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; endocytosis involved in viral entry into host cell [GO:0075509]; regulation of calcium-mediated signaling [GO:0050848]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15094197, ECO:0000269|PubMed:33758062}. Nucleus {ECO:0000269|PubMed:15094197}. Note=Colocalizes with type 1 ryanodine receptor (RYR1). {ECO:0000269|PubMed:33758062}.
Q9H936	reviewed	GHC1_HUMAN	Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22)	SLC25A22 GC1	Homo sapiens (Human)	323	FUNCTION: Mitochondrial glutamate/H(+) symporter. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (PubMed:11897791). Plays a role in the control of glucose-stimulated insulin secretion (By similarity). {ECO:0000250|UniProtKB:A0A0G2K5L2, ECO:0000269|PubMed:11897791}.		aspartate transmembrane transport [GO:0015810]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; monoatomic ion transport [GO:0006811]; regulation of insulin secretion [GO:0050796]	mitochondrial inner membrane [GO:0005743]	amino acid:proton symporter activity [GO:0005280]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]	mitochondrial inner membrane [GO:0005743]; amino acid:proton symporter activity [GO:0005280]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; aspartate transmembrane transport [GO:0015810]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; monoatomic ion transport [GO:0006811]; regulation of insulin secretion [GO:0050796]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:A0A0G2K5L2}; Multi-pass membrane protein {ECO:0000255}.
Q9H944	reviewed	MED20_HUMAN	Mediator of RNA polymerase II transcription subunit 20 (Mediator complex subunit 20) (TRF-proximal protein homolog) (hTRFP)	MED20 TRFP	Homo sapiens (Human)	212	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.		DNA-templated transcription [GO:0006351]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase II [GO:0006366]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; transcription coactivator activity [GO:0003713]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; transcription coactivator activity [GO:0003713]; DNA-templated transcription [GO:0006351]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H974	reviewed	QTRT2_HUMAN	Queuine tRNA-ribosyltransferase accessory subunit 2 (Queuine tRNA-ribosyltransferase domain-containing protein 1)	QTRT2 QTRTD1	Homo sapiens (Human)	415	FUNCTION: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). {ECO:0000255|HAMAP-Rule:MF_03043}.		tRNA-guanine transglycosylation [GO:0101030]	cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; transferase complex [GO:1990234]	metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479]	cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; transferase complex [GO:1990234]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479]; tRNA-guanine transglycosylation [GO:0101030]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03043}. Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03043}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03043}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03043}. Note=May associate with the mitochondrion outer membrane. {ECO:0000255|HAMAP-Rule:MF_03043}.
Q9H977	reviewed	WDR54_HUMAN	WD repeat-containing protein 54	WDR54	Homo sapiens (Human)	334	FUNCTION: When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. {ECO:0000269|PubMed:30458214}.		cilium assembly [GO:0060271]; negative regulation of receptor internalization [GO:0002091]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of MAPK cascade [GO:0043408]	axoneme [GO:0005930]; intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982]	protein homodimerization activity [GO:0042803]	axoneme [GO:0005930]; intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982]; protein homodimerization activity [GO:0042803]; cilium assembly [GO:0060271]; negative regulation of receptor internalization [GO:0002091]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of MAPK cascade [GO:0043408]	SUBCELLULAR LOCATION: Vesicle {ECO:0000269|PubMed:30458214}. Note=Aggregates in vesicles when cross-linked. {ECO:0000269|PubMed:30458214}.
Q9H981	reviewed	ARP8_HUMAN	Actin-related protein 8 (hArp8) (INO80 complex subunit N)	ACTR8 ARP8 INO80N	Homo sapiens (Human)	624	FUNCTION: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.		cell cycle [GO:0007049]; cell division [GO:0051301]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	centrosome [GO:0005813]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]	centrosome [GO:0005813]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18163988}. Chromosome {ECO:0000269|PubMed:18163988}. Note=Specifically localizes to mitotic chromosomes.
Q9H987	reviewed	SYP2L_HUMAN	Synaptopodin 2-like protein	SYNPO2L	Homo sapiens (Human)	977	FUNCTION: Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}.		heart morphogenesis [GO:0003007]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; sarcomere organization [GO:0045214]	actin cytoskeleton [GO:0015629]; nucleus [GO:0005634]; Z disc [GO:0030018]	actin binding [GO:0003779]	actin cytoskeleton [GO:0015629]; nucleus [GO:0005634]; Z disc [GO:0030018]; actin binding [GO:0003779]; heart morphogenesis [GO:0003007]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; sarcomere organization [GO:0045214]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q9H992	reviewed	MARH7_HUMAN	E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7)	MARCHF7 AXOT MARCH7 RNF177	Homo sapiens (Human)	704	FUNCTION: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:31270356}.		negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein autoubiquitination [GO:1905524]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein polyubiquitination [GO:1902916]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein stabilization [GO:0050821]; regulation of tolerance induction [GO:0002643]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	MDM2/MDM4 family protein binding [GO:0097371]; transferase activity [GO:0016740]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; MDM2/MDM4 family protein binding [GO:0097371]; transferase activity [GO:0016740]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; zinc ion binding [GO:0008270]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein autoubiquitination [GO:1905524]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein polyubiquitination [GO:1902916]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein stabilization [GO:0050821]; regulation of tolerance induction [GO:0002643]	
Q9H993	reviewed	ARMT1_HUMAN	Damage-control phosphatase ARMT1 (EC 3.1.3.-) (Acidic residue methyltransferase 1) (Protein-glutamate O-methyltransferase) (EC 2.1.1.-) (Sugar phosphate phosphatase ARMT1)	ARMT1 C6orf211	Homo sapiens (Human)	441	FUNCTION: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (PubMed:25732820). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (PubMed:25732820). {ECO:0000250|UniProtKB:Q04371, ECO:0000269|PubMed:25732820}.		DNA damage response [GO:0006974]; methylation [GO:0032259]		enzyme binding [GO:0019899]; fructose 6-phosphate aldolase activity [GO:0097023]; fructose-1-phosphatase activity [GO:0103026]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; protein carboxyl O-methyltransferase activity [GO:0051998]; protein-glutamate O-methyltransferase activity [GO:0008983]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	enzyme binding [GO:0019899]; fructose 6-phosphate aldolase activity [GO:0097023]; fructose-1-phosphatase activity [GO:0103026]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; protein carboxyl O-methyltransferase activity [GO:0051998]; protein-glutamate O-methyltransferase activity [GO:0008983]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; DNA damage response [GO:0006974]; methylation [GO:0032259]	
Q9H999	reviewed	PANK3_HUMAN	Pantothenate kinase 3 (hPanK3) (EC 2.7.1.33) (Pantothenic acid kinase 3)	PANK3	Homo sapiens (Human)	370	FUNCTION: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:17631502, ECO:0000269|PubMed:20797618, ECO:0000269|PubMed:27555321, ECO:0000269|PubMed:30927326}.		coenzyme A biosynthetic process [GO:0015937]; phosphorylation [GO:0016310]	cytosol [GO:0005829]; nucleus [GO:0005634]	acetyl-CoA binding [GO:1905502]; ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]; protein homodimerization activity [GO:0042803]; vitamin binding [GO:0019842]	cytosol [GO:0005829]; nucleus [GO:0005634]; acetyl-CoA binding [GO:1905502]; ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]; protein homodimerization activity [GO:0042803]; vitamin binding [GO:0019842]; coenzyme A biosynthetic process [GO:0015937]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23152917, ECO:0000305}.
Q9H9A5	reviewed	CNO10_HUMAN	CCR4-NOT transcription complex subunit 10	CNOT10	Homo sapiens (Human)	744	FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex. {ECO:0000269|PubMed:23221646}.		mRNA catabolic process [GO:0006402]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulatory ncRNA-mediated gene silencing [GO:0031047]	CCR4-NOT complex [GO:0030014]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]		CCR4-NOT complex [GO:0030014]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; mRNA catabolic process [GO:0006402]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulatory ncRNA-mediated gene silencing [GO:0031047]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Q9H9A7	reviewed	RMI1_HUMAN	RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75)	RMI1 C9orf76	Homo sapiens (Human)	625	FUNCTION: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}.		DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; glucose homeostasis [GO:0042593]; multicellular organism growth [GO:0035264]; reduction of food intake in response to dietary excess [GO:0002023]; resolution of meiotic recombination intermediates [GO:0000712]; resolution of recombination intermediates [GO:0071139]; response to glucose [GO:0009749]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RecQ family helicase-topoisomerase III complex [GO:0031422]	nucleotide binding [GO:0000166]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RecQ family helicase-topoisomerase III complex [GO:0031422]; nucleotide binding [GO:0000166]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; glucose homeostasis [GO:0042593]; multicellular organism growth [GO:0035264]; reduction of food intake in response to dietary excess [GO:0002023]; resolution of meiotic recombination intermediates [GO:0000712]; resolution of recombination intermediates [GO:0071139]; response to glucose [GO:0009749]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15775963}. Note=Forms foci in response to DNA damage.
Q9H9B1	reviewed	EHMT1_HUMAN	Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D)	EHMT1 EUHMTASE1 GLP KIAA1876 KMT1D	Homo sapiens (Human)	1298	FUNCTION: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250|UniProtKB:Q5DW34, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	chromatin organization [GO:0006325]; DNA methylation [GO:0006306]; facultative heterochromatin formation [GO:0140718]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of embryonic development [GO:0045995]; response to fungicide [GO:0060992]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	C2H2 zinc finger domain binding [GO:0070742]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9me2 methyltransferase activity [GO:0140947]; methyltransferase activity [GO:0008168]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; C2H2 zinc finger domain binding [GO:0070742]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9me2 methyltransferase activity [GO:0140947]; methyltransferase activity [GO:0008168]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; DNA methylation [GO:0006306]; facultative heterochromatin formation [GO:0140718]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of embryonic development [GO:0045995]; response to fungicide [GO:0060992]	SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Associates with euchromatic regions.
Q9H9B4	reviewed	SFXN1_HUMAN	Sideroflexin-1	SFXN1	Homo sapiens (Human)	322	FUNCTION: Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). May also transport other amino acids including alanine and cysteine (PubMed:30442778). {ECO:0000269|PubMed:30442778}.		erythrocyte differentiation [GO:0030218]; iron ion transport [GO:0006826]; L-alanine transport [GO:0015808]; L-serine transport [GO:0015825]; one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	L-alanine transmembrane transporter activity [GO:0015180]; L-serine transmembrane transporter activity [GO:0015194]; monoatomic ion transmembrane transporter activity [GO:0015075]; serine transmembrane transporter activity [GO:0022889]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; L-alanine transmembrane transporter activity [GO:0015180]; L-serine transmembrane transporter activity [GO:0015194]; monoatomic ion transmembrane transporter activity [GO:0015075]; serine transmembrane transporter activity [GO:0022889]; erythrocyte differentiation [GO:0030218]; iron ion transport [GO:0006826]; L-alanine transport [GO:0015808]; L-serine transport [GO:0015825]; one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:27184847, ECO:0000269|PubMed:30442778}; Multi-pass membrane protein {ECO:0000255}.
Q9H9C1	reviewed	SPE39_HUMAN	Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction)	VIPAS39 C14orf133 SPE39 VIPAR	Homo sapiens (Human)	493	FUNCTION: Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). {ECO:0000250|UniProtKB:Q23288, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}.		cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; peptidyl-lysine hydroxylation [GO:0017185]; phagosome-lysosome fusion [GO:0090385]; post-translational protein modification [GO:0043687]; spermatogenesis [GO:0007283]; vacuolar transport [GO:0007034]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; vesicle tethering complex [GO:0099023]	protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; vesicle tethering complex [GO:0099023]; protein-containing complex binding [GO:0044877]; cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; peptidyl-lysine hydroxylation [GO:0017185]; phagosome-lysosome fusion [GO:0090385]; post-translational protein modification [GO:0043687]; spermatogenesis [GO:0007283]; vacuolar transport [GO:0007034]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Early endosome {ECO:0000269|PubMed:19109425}. Recycling endosome {ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:22753090}. Late endosome {ECO:0000269|PubMed:19109425}. Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles (PubMed:19109425).
Q9H9D4	reviewed	ZN408_HUMAN	Zinc finger protein 408 (PR domain zinc finger protein 17)	ZNF408 PFM14 PRDM17	Homo sapiens (Human)	720	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23716654, ECO:0000269|PubMed:25882705}.
Q9H9E1	reviewed	ANRA2_HUMAN	Ankyrin repeat family A protein 2 (RFXANK-like protein 2)	ANKRA2 ANKRA	Homo sapiens (Human)	313	FUNCTION: May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity). {ECO:0000250|UniProtKB:A2ARV4, ECO:0000269|PubMed:25752541}.		regulation of gene expression [GO:0010468]; regulation of protein-containing complex assembly [GO:0043254]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	histone deacetylase binding [GO:0042826]; low-density lipoprotein particle receptor binding [GO:0050750]; protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; histone deacetylase binding [GO:0042826]; low-density lipoprotein particle receptor binding [GO:0050750]; protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625]; regulation of gene expression [GO:0010468]; regulation of protein-containing complex assembly [GO:0043254]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q99PE2}. Membrane {ECO:0000250|UniProtKB:Q99PE2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99PE2}.
Q9H9E3	reviewed	COG4_HUMAN	Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4)	COG4	Homo sapiens (Human)	785	FUNCTION: Required for normal Golgi function (PubMed:19536132, PubMed:30290151). Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (PubMed:19536132). {ECO:0000269|PubMed:19536132, ECO:0000269|PubMed:30290151}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	glycosylation [GO:0070085]; Golgi organization [GO:0007030]; Golgi vesicle prefusion complex stabilization [GO:0048213]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588]; identical protein binding [GO:0042802]; glycosylation [GO:0070085]; Golgi organization [GO:0007030]; Golgi vesicle prefusion complex stabilization [GO:0048213]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:30290151}. Golgi apparatus membrane {ECO:0000305|PubMed:11703943}; Peripheral membrane protein {ECO:0000305|PubMed:11703943}; Cytoplasmic side {ECO:0000305|PubMed:11703943}. Note=Mosty cytosolic, with about 5% membrane-bound. {ECO:0000269|PubMed:30290151}.
Q9H9F9	reviewed	ARP5_HUMAN	Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16)	ACTR5 ARP5	Homo sapiens (Human)	607	FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. {ECO:0000269|PubMed:19014934, ECO:0000269|PubMed:20855601}.		chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]; UV-damage excision repair [GO:0070914]	cytoplasm [GO:0005737]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]; UV-damage excision repair [GO:0070914]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:18163988, ECO:0000269|PubMed:19014934}. Cytoplasm {ECO:0000269|PubMed:19014934}. Note=Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling (PubMed:19014934). Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses (PubMed:18163988).
Q9H9G7	reviewed	AGO3_HUMAN	Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)	AGO3 EIF2C3	Homo sapiens (Human)	860	FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713). {ECO:0000255|HAMAP-Rule:MF_03032, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:23064648, ECO:0000269|PubMed:29040713}.		miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA catabolic process [GO:0006402]; positive regulation of gene expression [GO:0010628]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; pre-miRNA processing [GO:0031054]; regulation of stem cell proliferation [GO:0072091]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]	condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]	double-stranded RNA binding [GO:0003725]; endoribonuclease activity, cleaving miRNA-paired mRNA [GO:0090624]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]	condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]; double-stranded RNA binding [GO:0003725]; endoribonuclease activity, cleaving miRNA-paired mRNA [GO:0090624]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA catabolic process [GO:0006402]; positive regulation of gene expression [GO:0010628]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; pre-miRNA processing [GO:0031054]; regulation of stem cell proliferation [GO:0072091]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03032, ECO:0000269|PubMed:16081698}.
Q9H9H4	reviewed	VP37B_HUMAN	Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B)	VPS37B	Homo sapiens (Human)	285	FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15218037}.		macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076]	cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; midbody [GO:0030496]; plasma membrane [GO:0005886]	calcium-dependent protein binding [GO:0048306]	cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; midbody [GO:0030496]; plasma membrane [GO:0005886]; calcium-dependent protein binding [GO:0048306]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:15218037}; Peripheral membrane protein {ECO:0000269|PubMed:15218037}. Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion.
Q9H9J2	reviewed	RM44_HUMAN	Large ribosomal subunit protein mL44 (EC 3.1.26.-) (39S ribosomal protein L44, mitochondrial) (L44mt) (MRP-L44)	MRPL44	Homo sapiens (Human)	332	FUNCTION: Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. {ECO:0000269|PubMed:23315540}.		mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; rRNA processing [GO:0006364]	microprocessor complex [GO:0070877]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	double-stranded RNA binding [GO:0003725]; endonuclease activity [GO:0004519]; RNA binding [GO:0003723]	microprocessor complex [GO:0070877]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; double-stranded RNA binding [GO:0003725]; endonuclease activity [GO:0004519]; RNA binding [GO:0003723]; mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9H9J4	reviewed	UBP42_HUMAN	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42)	USP42	Homo sapiens (Human)	1324	FUNCTION: Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; protein deubiquitination [GO:0016579]; regulation of apoptotic process [GO:0042981]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cell differentiation [GO:0030154]; protein deubiquitination [GO:0016579]; regulation of apoptotic process [GO:0042981]; spermatogenesis [GO:0007283]	
Q9H9K5	reviewed	MER34_HUMAN	Endogenous retroviral envelope protein HEMO (Endogenous retrovirus group MER34 member 1 Env polyprotein) (HERV-MER_4q12 provirus ancestral Env polyprotein) (Human endogenous MER34 (medium-reiteration-frequency-family-34) open reading frame) (Human endogenous MER34 ORF) (HEMO) [Cleaved into: Endogenous retroviral envelope protein HEMO, secreted form (Endogenous retroviral envelope protein HEMO, 48 kDa form)]	ERVMER34-1 HEMO LP9056	Homo sapiens (Human)	563	FUNCTION: Endogenous envelope proteins originate from retroviral envelope proteins, which mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. {ECO:0000305}.			extracellular region [GO:0005576]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: [Endogenous retroviral envelope protein HEMO]: Cell membrane {ECO:0000269|PubMed:28739914}; Single-pass type I membrane protein {ECO:0000255}. Note=This uncleaved form present at the cell surface represents the major form (PubMed:28739914). {ECO:0000269|PubMed:28739914}.; SUBCELLULAR LOCATION: [Endogenous retroviral envelope protein HEMO, secreted form]: Secreted {ECO:0000269|PubMed:28739914}. Note=This secreted form, which is released in the extracellular medium following cleavage, constitutes a minor form (PubMed:28739914). {ECO:0000269|PubMed:28739914}.
Q9H9L4	reviewed	KANL2_HUMAN	KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog)	KANSL2 C12orf41 NSL2	Homo sapiens (Human)	492	FUNCTION: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269|PubMed:20018852}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20018852}.
Q9H9L7	reviewed	AKIR1_HUMAN	Akirin-1	AKIRIN1 C1orf108	Homo sapiens (Human)	192	FUNCTION: Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development (By similarity). Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis (By similarity). May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway (By similarity). In contrast to AKIRIN2, not involved in nuclear import of proteasomes (PubMed:34711951). {ECO:0000250|UniProtKB:Q99LF1, ECO:0000269|PubMed:34711951}.	MISCELLANEOUS: 'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal. {ECO:0000305|PubMed:18066067}.	myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coregulator activity [GO:0003712]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18066067}.
Q9H9P2	reviewed	CHODL_HUMAN	Chondrolectin (Transmembrane protein MT75)	CHODL C21orf68 PRED12 UNQ872/PRO1890	Homo sapiens (Human)	273	FUNCTION: May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance. {ECO:0000250|UniProtKB:Q568T5, ECO:0000250|UniProtKB:Q9CXM0}.	MISCELLANEOUS: A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells. {ECO:0000305|PubMed:22042635}.; MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 1. {ECO:0000305}.	muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of axonogenesis [GO:0050772]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]	carbohydrate binding [GO:0030246]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; carbohydrate binding [GO:0030246]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of axonogenesis [GO:0050772]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22042635}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum {ECO:0000269|PubMed:12621022}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:12621022}.
Q9H9P5	reviewed	UNKL_HUMAN	Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like)	UNKL C16orf28 ZC3H5L ZC3HDC5L	Homo sapiens (Human)	680	FUNCTION: May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven. {ECO:0000269|PubMed:20148946}.	MISCELLANEOUS: [Isoform 4]: Splice site between exons 6 and 7 is non-canonical.	protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; transferase activity [GO:0016740]	cytosol [GO:0005829]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; transferase activity [GO:0016740]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus. Note=Isoform 4 is primarily localized in the cytoplasm but has the ability to shuttle between the nucleus and the cytoplasm.
Q9H9P8	reviewed	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2) (Duranin)	L2HGDH C14orf160	Homo sapiens (Human)	463		MISCELLANEOUS: Was named 'duranin' in honor of Marinus Duran, who first described L-2-hydroxyglutaric aciduria.	2-oxoglutarate metabolic process [GO:0006103]; small molecule metabolic process [GO:0044281]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	2-hydroxyglutarate dehydrogenase activity [GO:0047545]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; 2-hydroxyglutarate dehydrogenase activity [GO:0047545]; 2-oxoglutarate metabolic process [GO:0006103]; small molecule metabolic process [GO:0044281]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16005139}.
Q9H9Q2	reviewed	CSN7B_HUMAN	COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b)	COPS7B CSN7B	Homo sapiens (Human)	264	FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143}.		COP9 signalosome assembly [GO:0010387]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; COP9 signalosome assembly [GO:0010387]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q9H9Q4	reviewed	NHEJ1_HUMAN	Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor)	NHEJ1 XLF	Homo sapiens (Human)	299	FUNCTION: DNA repair protein involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination (PubMed:16439204, PubMed:16439205, PubMed:17717001, PubMed:17317666, PubMed:17470781, PubMed:18644470, PubMed:20558749, PubMed:26100018, PubMed:18158905). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (PubMed:17717001, PubMed:17470781, PubMed:19056826). Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:30250067, PubMed:25670504). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781). Associates with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:22228831, PubMed:26100018, PubMed:28500754, PubMed:27437582, PubMed:21775435, PubMed:22287571, PubMed:21768349). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:28500754, PubMed:27437582). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Binds DNA in a length-dependent manner (PubMed:17317666, PubMed:18158905). {ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:17317666, ECO:0000269|PubMed:17470781, ECO:0000269|PubMed:17717001, ECO:0000269|PubMed:18158905, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:19056826, ECO:0000269|PubMed:20558749, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25670504, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30250067}.	MISCELLANEOUS: Was named 'Cernunnos' after the enigmatic Celtic god of hunting, the underworld and fertility.	B cell differentiation [GO:0030183]; central nervous system development [GO:0007417]; DNA ligation involved in DNA repair [GO:0051103]; double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; positive regulation of ligase activity [GO:0051351]; response to ionizing radiation [GO:0010212]; T cell differentiation [GO:0030217]	DNA ligase IV complex [GO:0032807]; fibrillar center [GO:0001650]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	DNA end binding [GO:0045027]; DNA polymerase binding [GO:0070182]	DNA ligase IV complex [GO:0032807]; fibrillar center [GO:0001650]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; DNA end binding [GO:0045027]; DNA polymerase binding [GO:0070182]; B cell differentiation [GO:0030183]; central nervous system development [GO:0007417]; DNA ligation involved in DNA repair [GO:0051103]; double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; positive regulation of ligase activity [GO:0051351]; response to ionizing radiation [GO:0010212]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:20558749}. Chromosome {ECO:0000269|PubMed:18064046, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:27437582}. Note=Localizes to site of double-strand breaks; recruitment is dependent on XRCC5-XRCC6 (Ku) heterodimer. {ECO:0000269|PubMed:18064046, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:27437582}.
Q9H9S0	reviewed	NANOG_HUMAN	Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog)	NANOG	Homo sapiens (Human)	305	FUNCTION: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269|PubMed:15983365, ECO:0000269|PubMed:16000880, ECO:0000269|PubMed:16391521, ECO:0000269|PubMed:25825768}.	MISCELLANEOUS: Exists an other tandem duplicated non-processed pseudogene (NANOGP1) and 10 other NANOG-related nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene.	cell differentiation [GO:0030154]; endodermal cell fate specification [GO:0001714]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; stem cell population maintenance [GO:0019827]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cell differentiation [GO:0030154]; endodermal cell fate specification [GO:0001714]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15983365}.
Q9H9S5	reviewed	FKRP_HUMAN	Ribitol 5-phosphate transferase FKRP (EC 2.7.8.-) (Fukutin-related protein) (Ribitol-5-phosphate transferase)	FKRP	Homo sapiens (Human)	495	FUNCTION: Catalyzes the transfer of a ribitol 5-phosphate from CDP-L-ribitol to the ribitol 5-phosphate previously attached by FKTN/fukutin to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:26923585, PubMed:29477842, PubMed:31949166, PubMed:27194101). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:25279699, PubMed:26923585, PubMed:29477842, PubMed:31949166, PubMed:27194101). {ECO:0000269|PubMed:25279699, ECO:0000269|PubMed:26923585, ECO:0000269|PubMed:27194101, ECO:0000269|PubMed:29477842, ECO:0000269|PubMed:31949166}.		brain development [GO:0007420]; localization of cell [GO:0051674]; protein O-linked mannosylation [GO:0035269]; protein processing [GO:0016485]; protein tetramerization [GO:0051262]; skeletal muscle tissue regeneration [GO:0043403]	cytosol [GO:0005829]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; rough endoplasmic reticulum [GO:0005791]; sarcolemma [GO:0042383]	dystroglycan binding [GO:0002162]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]	cytosol [GO:0005829]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; rough endoplasmic reticulum [GO:0005791]; sarcolemma [GO:0042383]; dystroglycan binding [GO:0002162]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; brain development [GO:0007420]; localization of cell [GO:0051674]; protein O-linked mannosylation [GO:0035269]; protein processing [GO:0016485]; protein tetramerization [GO:0051262]; skeletal muscle tissue regeneration [GO:0043403]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17554798, ECO:0000269|PubMed:21886772, ECO:0000269|PubMed:25279699, ECO:0000269|PubMed:29477842, ECO:0000305|PubMed:26923585}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:19900540}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q8CG64}. Rough endoplasmic reticulum {ECO:0000269|PubMed:15213246}. Cytoplasm {ECO:0000250|UniProtKB:Q8CG64}. Note=According to some studies the N-terminal hydrophobic domain is cleaved after translocation to the Golgi apparatus and the protein is secreted (PubMed:19900540). Localization at the cell membrane may require the presence of dystroglycan (By similarity). At the Golgi apparatus localizes to the middle-to-trans-cisternae, as assessed by MG160 colocalization. Detected in rough endoplasmic reticulum in myocytes (PubMed:17554798, PubMed:21886772). In general, mutants associated with severe clinical phenotypes are retained within the endoplasmic reticulum (PubMed:15213246). {ECO:0000250|UniProtKB:Q8CG64, ECO:0000269|PubMed:15213246, ECO:0000269|PubMed:17554798, ECO:0000269|PubMed:19900540, ECO:0000269|PubMed:21886772}.
Q9H9T3	reviewed	ELP3_HUMAN	Elongator complex protein 3 (hELP3) (EC 2.3.1.-) (tRNA uridine(34) acetyltransferase)	ELP3	Homo sapiens (Human)	547	FUNCTION: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29415125). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (PubMed:29415125). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). {ECO:0000250|UniProtKB:D5VRB9, ECO:0000250|UniProtKB:Q9CZX0, ECO:0000269|PubMed:19185337, ECO:0000269|PubMed:29415125}.		central nervous system development [GO:0007417]; neuron migration [GO:0001764]; positive regulation of cell migration [GO:0030335]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926]; tRNA wobble uridine modification [GO:0002098]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleolus [GO:0005730]; nucleus [GO:0005634]	4 iron, 4 sulfur cluster binding [GO:0051539]; acetyltransferase activity [GO:0016407]; metal ion binding [GO:0046872]; phosphorylase kinase regulator activity [GO:0008607]; tRNA binding [GO:0000049]; tRNA uridine(34) acetyltransferase activity [GO:0106261]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleolus [GO:0005730]; nucleus [GO:0005634]; 4 iron, 4 sulfur cluster binding [GO:0051539]; acetyltransferase activity [GO:0016407]; metal ion binding [GO:0046872]; phosphorylase kinase regulator activity [GO:0008607]; tRNA binding [GO:0000049]; tRNA uridine(34) acetyltransferase activity [GO:0106261]; central nervous system development [GO:0007417]; neuron migration [GO:0001764]; positive regulation of cell migration [GO:0030335]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926]; tRNA wobble uridine modification [GO:0002098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:19185337, ECO:0000269|PubMed:22854966}. Nucleus {ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:22854966}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:22002106}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:22002106}. Nucleus {ECO:0000269|PubMed:22002106}.
Q9H9V4	reviewed	RN122_HUMAN	RING finger protein 122	RNF122	Homo sapiens (Human)	155	FUNCTION: May induce necrosis and apoptosis. May play a role in cell viability. {ECO:0000269|PubMed:16751333}.		negative regulation of mitochondrial membrane potential [GO:0010917]; positive regulation of apoptotic process [GO:0043065]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of mitochondrial membrane potential [GO:0010917]; positive regulation of apoptotic process [GO:0043065]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:16778963}. Endoplasmic reticulum {ECO:0000269|PubMed:16778963}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9H9V9	reviewed	JMJD4_HUMAN	2-oxoglutarate and iron-dependent oxygenase JMJD4 (EC 1.14.11.-) (JmjC domain-containing protein 4) (Jumonji domain-containing protein 4) (Lysyl-hydroxylase JMJD4)	JMJD4	Homo sapiens (Human)	463	FUNCTION: Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1. {ECO:0000269|PubMed:24486019}.		positive regulation of translational termination [GO:0045905]; protein hydroxylation [GO:0018126]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; metal ion binding [GO:0046872]; peptidyl-lysine 4-dioxygenase activity [GO:0106156]; sequence-specific DNA binding [GO:0043565]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; metal ion binding [GO:0046872]; peptidyl-lysine 4-dioxygenase activity [GO:0106156]; sequence-specific DNA binding [GO:0043565]; positive regulation of translational termination [GO:0045905]; protein hydroxylation [GO:0018126]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24486019}.
Q9H9Y6	reviewed	RPA2_HUMAN	DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135)	POLR1B	Homo sapiens (Human)	1135	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. {ECO:0000305|PubMed:16809778}.		embryo implantation [GO:0007566]; neural crest formation [GO:0014029]; nucleologenesis [GO:0017126]; rRNA transcription [GO:0009303]; transcription by RNA polymerase I [GO:0006360]	chromosome [GO:0005694]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549]	chromosome [GO:0005694]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549]; embryo implantation [GO:0007566]; neural crest formation [GO:0014029]; nucleologenesis [GO:0017126]; rRNA transcription [GO:0009303]; transcription by RNA polymerase I [GO:0006360]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11250903}. Chromosome {ECO:0000250|UniProtKB:P70700}.
Q9H9Z2	reviewed	LN28A_HUMAN	Protein lin-28 homolog A (Lin-28A) (Zinc finger CCHC domain-containing protein 1)	LIN28A CSDD1 LIN28 ZCCHC1	Homo sapiens (Human)	209	FUNCTION: RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferases (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). This results in the terminal uridylation of target pre-miRNAs (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity). {ECO:0000250|UniProtKB:Q8K3Y3, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:22118463, ECO:0000269|PubMed:22898984, ECO:0000305}.	MISCELLANEOUS: Overexpressed in primary tumors (overall frequency approximately 15%), overexpression being linked to repression of let-7 family miRNAs and derepression of let-7 targets. Facilitates cellular transformation in vitro, and overexpression is associated with advanced disease across multiple tumor types. {ECO:0000269|PubMed:19483683}.; MISCELLANEOUS: Reactivation of LIN28A expression enhances tissue repair in some adult tissues by reprogramming cellular bioenergetics. Improves hair regrowth by promoting anagen in hair follicle and accelerates regrowth of cartilage, bone and mesenchyme after ear and digit injuries. {ECO:0000250|UniProtKB:Q8K3Y3}.	cellular response to glucose stimulus [GO:0071333]; germ cell development [GO:0007281]; miRNA catabolic process [GO:0010587]; negative regulation of glial cell differentiation [GO:0045686]; negative regulation of pre-miRNA processing [GO:2000632]; negative regulation of translation [GO:0017148]; positive regulation of cell proliferation involved in kidney development [GO:1901724]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of TOR signaling [GO:0032008]; pre-miRNA processing [GO:0031054]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; P-body [GO:0000932]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; rough endoplasmic reticulum [GO:0005791]	G-quadruplex RNA binding [GO:0002151]; miRNA binding [GO:0035198]; mRNA binding [GO:0003729]; polysome binding [GO:1905538]; pre-miRNA binding [GO:0070883]; protein-RNA adaptor activity [GO:0140517]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; translation initiation factor binding [GO:0031369]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; P-body [GO:0000932]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; rough endoplasmic reticulum [GO:0005791]; G-quadruplex RNA binding [GO:0002151]; miRNA binding [GO:0035198]; mRNA binding [GO:0003729]; polysome binding [GO:1905538]; pre-miRNA binding [GO:0070883]; protein-RNA adaptor activity [GO:0140517]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; translation initiation factor binding [GO:0031369]; zinc ion binding [GO:0008270]; cellular response to glucose stimulus [GO:0071333]; germ cell development [GO:0007281]; miRNA catabolic process [GO:0010587]; negative regulation of glial cell differentiation [GO:0045686]; negative regulation of pre-miRNA processing [GO:2000632]; negative regulation of translation [GO:0017148]; positive regulation of cell proliferation involved in kidney development [GO:1901724]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of TOR signaling [GO:0032008]; pre-miRNA processing [GO:0031054]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:22118463}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q8K3Y3}. Cytoplasm, P-body {ECO:0000269|PubMed:17617744}. Cytoplasm, Stress granule {ECO:0000269|PubMed:17617744}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8K3Y3}. Note=Predominantly cytoplasmic (PubMed:22118463). In the cytoplasm, localizes to peri-endoplasmic reticulum regions and detected in the microsomal fraction derived from rough endoplasmic reticulum (RER) following subcellular fractionation. May be bound to the cytosolic surface of RER on which ER-associated mRNAs are translated (By similarity). Shuttle from the nucleus to the cytoplasm requires RNA-binding (PubMed:17617744). Nucleolar localization is observed in 10-15% of the nuclei in differentiated myotubes (By similarity). {ECO:0000250|UniProtKB:Q8K3Y3, ECO:0000269|PubMed:17617744, ECO:0000269|PubMed:22118463}.
Q9HA38	reviewed	ZMAT3_HUMAN	Zinc finger matrin-type protein 3 (Zinc finger protein WIG-1) (p53-activated gene 608 protein)	ZMAT3 PAG608 WIG1	Homo sapiens (Human)	289	FUNCTION: Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus. {ECO:0000269|PubMed:11571644}.		apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; protein transport [GO:0015031]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11571644}. Nucleus, nucleolus {ECO:0000269|PubMed:11571644}.
Q9HA47	reviewed	UCK1_HUMAN	Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1)	UCK1 URK1	Homo sapiens (Human)	277	FUNCTION: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702). {ECO:0000269|PubMed:11306702}.		CTP salvage [GO:0044211]; phosphorylation [GO:0016310]; UMP salvage [GO:0044206]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; uridine kinase activity [GO:0004849]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; uridine kinase activity [GO:0004849]; CTP salvage [GO:0044211]; phosphorylation [GO:0016310]; UMP salvage [GO:0044206]	
Q9HA64	reviewed	KT3K_HUMAN	Ketosamine-3-kinase (EC 2.7.1.172) (Fructosamine-3-kinase-related protein) (FN3K-RP) (FN3K-related protein) (Protein-psicosamine 3-kinase FN3KRP) (EC 2.7.1.-)	FN3KRP	Homo sapiens (Human)	309	FUNCTION: Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively (PubMed:14633848, PubMed:15137908). Ribuloselysine-3 phosphate and psicoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:14633848, PubMed:15137908). Not able to phosphorylate fructoselysine (PubMed:14633848). {ECO:0000269|PubMed:14633848, ECO:0000269|PubMed:15137908}.		phosphorylation [GO:0016310]; post-translational protein modification [GO:0043687]	cytosol [GO:0005829]	ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein-ribulosamine 3-kinase activity [GO:0102193]	cytosol [GO:0005829]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein-ribulosamine 3-kinase activity [GO:0102193]; phosphorylation [GO:0016310]; post-translational protein modification [GO:0043687]	
Q9HA65	reviewed	TBC17_HUMAN	TBC1 domain family member 17	TBC1D17	Homo sapiens (Human)	648	FUNCTION: Probable RAB GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR) (PubMed:22854040). Involved in regulation of autophagy. {ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:24752605}.		autophagy [GO:0006914]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]	autophagosome [GO:0005776]; cytosol [GO:0005829]; recycling endosome [GO:0055037]	GTPase activator activity [GO:0005096]	autophagosome [GO:0005776]; cytosol [GO:0005829]; recycling endosome [GO:0055037]; GTPase activator activity [GO:0005096]; autophagy [GO:0006914]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24752605}. Cytoplasm {ECO:0000269|PubMed:22854040}. Recycling endosome {ECO:0000269|PubMed:22854040}. Note=In the presence of optineurin/OPTN, may be recruited to recycling endosomes. {ECO:0000269|PubMed:22854040}.
Q9HA82	reviewed	CERS4_HUMAN	Ceramide synthase 4 (CerS4) (EC 2.3.1.-) (LAG1 longevity assurance homolog 4) (Sphingosine N-acyltransferase CERS4) (EC 2.3.1.24)	CERS4 LASS4	Homo sapiens (Human)	394	FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. {ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068, ECO:0000269|PubMed:31916624}.		ceramide biosynthetic process [GO:0046513]; sphingolipid biosynthetic process [GO:0030148]	endoplasmic reticulum membrane [GO:0005789]	DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291]	endoplasmic reticulum membrane [GO:0005789]; DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291]; ceramide biosynthetic process [GO:0046513]; sphingolipid biosynthetic process [GO:0030148]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D6J1}; Multi-pass membrane protein {ECO:0000255}.
Q9HAB3	reviewed	S52A2_HUMAN	Solute carrier family 52, riboflavin transporter, member 2 (Porcine endogenous retrovirus A receptor 1) (PERV-A receptor 1) (Protein GPR172A) (Riboflavin transporter 3) (hRFT3)	SLC52A2 GPR172A PAR1 RFT3	Homo sapiens (Human)	445	FUNCTION: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:20463145, PubMed:22864630, PubMed:23243084, PubMed:24253200, PubMed:27702554). Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145). May also act as a receptor for 4-hydroxybutyrate (Probable). {ECO:0000269|PubMed:20463145, ECO:0000269|PubMed:22864630, ECO:0000269|PubMed:23243084, ECO:0000269|PubMed:24253200, ECO:0000269|PubMed:27702554, ECO:0000303|PubMed:20463145, ECO:0000305|PubMed:17197387}.; FUNCTION: (Microbial infection) In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). {ECO:0000269|PubMed:12740431, ECO:0000269|PubMed:19307586}.		riboflavin metabolic process [GO:0006771]; riboflavin transport [GO:0032218]	plasma membrane [GO:0005886]	4-hydroxybutyrate receptor activity [GO:0062124]; riboflavin transmembrane transporter activity [GO:0032217]; virus receptor activity [GO:0001618]	plasma membrane [GO:0005886]; 4-hydroxybutyrate receptor activity [GO:0062124]; riboflavin transmembrane transporter activity [GO:0032217]; virus receptor activity [GO:0001618]; riboflavin metabolic process [GO:0006771]; riboflavin transport [GO:0032218]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17197387, ECO:0000269|PubMed:20463145, ECO:0000269|PubMed:24253200, ECO:0000269|PubMed:27702554}; Multi-pass membrane protein {ECO:0000255}.
Q9HAB8	reviewed	PPCS_HUMAN	Phosphopantothenate--cysteine ligase (EC 6.3.2.51) (Phosphopantothenoylcysteine synthetase) (PPC synthetase)	PPCS COAB	Homo sapiens (Human)	311	FUNCTION: Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:11923312, PubMed:12906824, PubMed:29754768). Has a preference for ATP over CTP as a cosubstrate (PubMed:11923312). {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:12906824, ECO:0000269|PubMed:29754768}.		acetyl-CoA biosynthetic process [GO:0006085]; coenzyme A biosynthetic process [GO:0015937]; heart process [GO:0003015]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphopantothenate--cysteine ligase activity [GO:0004632]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphopantothenate--cysteine ligase activity [GO:0004632]; protein homodimerization activity [GO:0042803]; acetyl-CoA biosynthetic process [GO:0006085]; coenzyme A biosynthetic process [GO:0015937]; heart process [GO:0003015]	
Q9HAC7	reviewed	SUCHY_HUMAN	Succinate--hydroxymethylglutarate CoA-transferase (EC 2.8.3.13) (Dermal papilla-derived protein 13) (SuccinylCoA:glutarate-CoA transferase)	SUGCT C7orf10 DERP13	Homo sapiens (Human)	445	FUNCTION: Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate. {ECO:0000269|PubMed:23893049}.			mitochondrion [GO:0005739]	succinate-hydroxymethylglutarate CoA-transferase activity [GO:0047369]	mitochondrion [GO:0005739]; succinate-hydroxymethylglutarate CoA-transferase activity [GO:0047369]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23893049}.
Q9HAC8	reviewed	UBTD1_HUMAN	Ubiquitin domain-containing protein 1	UBTD1	Homo sapiens (Human)	227	FUNCTION: May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2. {ECO:0000269|PubMed:25382750}.						
Q9HAD4	reviewed	WDR41_HUMAN	WD repeat-containing protein 41	WDR41 MSTP048	Homo sapiens (Human)	459	FUNCTION: Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (PubMed:32303654). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292). {ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}.		autophagy [GO:0006914]; negative regulation of exocytosis [GO:0045920]; negative regulation of immune response [GO:0050777]; positive regulation of GTPase activity [GO:0043547]; regulation of autophagy [GO:0010506]	cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor complex [GO:0032045]; lysosomal membrane [GO:0005765]		cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor complex [GO:0032045]; lysosomal membrane [GO:0005765]; autophagy [GO:0006914]; negative regulation of exocytosis [GO:0045920]; negative regulation of immune response [GO:0050777]; positive regulation of GTPase activity [GO:0043547]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27193190}.
Q9HAF1	reviewed	EAF6_HUMAN	Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91)	MEAF6 C1orf149 CENP-28 EAF6	Homo sapiens (Human)	191	FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A (PubMed:14966270). This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:18794358). {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767}.		chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of developmental process [GO:0050793]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of hemopoiesis [GO:1903706]	histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]		histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of developmental process [GO:0050793]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of hemopoiesis [GO:1903706]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:18794358}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
Q9HAI6	reviewed	TASL_HUMAN	TLR adapter interacting with SLC15A4 on the lysosome	TASL CXorf21	Homo sapiens (Human)	301	FUNCTION: Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:32433612). Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons (PubMed:32433612). Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes (PubMed:31001245). {ECO:0000269|PubMed:31001245, ECO:0000269|PubMed:32433612}.		innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 8 signaling pathway [GO:0034161]; regulation of lysosomal lumen pH [GO:0035751]; regulation of toll-like receptor signaling pathway [GO:0034121]	endolysosome membrane [GO:0036020]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]		endolysosome membrane [GO:0036020]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 8 signaling pathway [GO:0034161]; regulation of lysosomal lumen pH [GO:0035751]; regulation of toll-like receptor signaling pathway [GO:0034121]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:31092820, ECO:0000269|PubMed:32433612}. Endosome membrane {ECO:0000269|PubMed:32433612}. Nucleus {ECO:0000269|PubMed:31092820}. Cytoplasm {ECO:0000269|PubMed:31092820}. Note=Recruited to endolysosome following interaction with SLC15A4 (PubMed:32433612). May colocalize with TLR7 in the endosomal pathway (PubMed:31092820). {ECO:0000269|PubMed:31092820, ECO:0000269|PubMed:32433612}.
Q9HAJ7	reviewed	SP30L_HUMAN	Histone deacetylase complex subunit SAP30L (HCV non-structural protein 4A-transactivated protein 2) (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like)	SAP30L NS4ATP2	Homo sapiens (Human)	183	FUNCTION: [Isoform 1]: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). {ECO:0000269|PubMed:16820529, ECO:0000269|PubMed:18070604, ECO:0000269|PubMed:19015240, ECO:0000269|PubMed:26609676}.; FUNCTION: [Isoform 2]: Functions as transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:18070604}.; FUNCTION: [Isoform 3]: Functions as transcription repressor; its activity is marginally lower than that of isoform 1. {ECO:0000269|PubMed:18070604}.		negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of DNA-templated transcription [GO:0006355]	fibrillar center [GO:0001650]; histone deacetylase complex [GO:0000118]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]	DNA binding [GO:0003677]; histone binding [GO:0042393]; non-sequence-specific DNA binding, bending [GO:0044378]; nucleosome binding [GO:0031491]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]	fibrillar center [GO:0001650]; histone deacetylase complex [GO:0000118]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; DNA binding [GO:0003677]; histone binding [GO:0042393]; non-sequence-specific DNA binding, bending [GO:0044378]; nucleosome binding [GO:0031491]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleolus {ECO:0000269|PubMed:14680513, ECO:0000269|PubMed:16820529, ECO:0000269|PubMed:18070604, ECO:0000269|PubMed:19015240}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, nucleolus {ECO:0000269|PubMed:18070604}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleolus {ECO:0000269|PubMed:18070604}.
Q9HAK2	reviewed	COE2_HUMAN	Transcription factor COE2 (Early B-cell factor 2) (EBF-2)	EBF2 COE2	Homo sapiens (Human)	575	FUNCTION: Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). {ECO:0000250}.		adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; cell fate determination [GO:0001709]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; cell fate determination [GO:0001709]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9HAN9	reviewed	NMNA1_HUMAN	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide-nucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1)	NMNAT1 NMNAT	Homo sapiens (Human)	279	FUNCTION: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults (By similarity). {ECO:0000250|UniProtKB:Q9EPA7, ECO:0000269|PubMed:17402747, ECO:0000269|PubMed:27257257}.		ATP generation from poly-ADP-D-ribose [GO:1990966]; NAD biosynthetic process [GO:0009435]; negative regulation of apoptotic DNA fragmentation [GO:1902511]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; nucleotide biosynthetic process [GO:0009165]; positive regulation of MAPK cascade [GO:0043410]; response to wounding [GO:0009611]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]; ATP generation from poly-ADP-D-ribose [GO:1990966]; NAD biosynthetic process [GO:0009435]; negative regulation of apoptotic DNA fragmentation [GO:1902511]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; nucleotide biosynthetic process [GO:0009165]; positive regulation of MAPK cascade [GO:0043410]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11248244, ECO:0000269|PubMed:12574164, ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:22842230}.
Q9HAP2	reviewed	MLXIP_HUMAN	MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA)	MLXIP BHLHE36 KIAA0867 MIR MONDOA	Homo sapiens (Human)	919	FUNCTION: Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Mitochondrion outer membrane {ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
Q9HAP6	reviewed	LIN7B_HUMAN	Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)	LIN7B MALS2 VELI2 UNQ3116/PRO10200	Homo sapiens (Human)	207	FUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O88951, ECO:0000269|PubMed:11742811}.		exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neurotransmitter secretion [GO:0007269]; protein localization to basolateral plasma membrane [GO:1903361]; protein transport [GO:0015031]	basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; MPP7-DLG1-LIN7 complex [GO:0097025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; synapse [GO:0045202]	L27 domain binding [GO:0097016]; PDZ domain binding [GO:0030165]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]	basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; MPP7-DLG1-LIN7 complex [GO:0097025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; synapse [GO:0045202]; L27 domain binding [GO:0097016]; PDZ domain binding [GO:0030165]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neurotransmitter secretion [GO:0007269]; protein localization to basolateral plasma membrane [GO:1903361]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O88951}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Basolateral cell membrane {ECO:0000269|PubMed:11742811, ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Cell junction {ECO:0000250|UniProtKB:O88951}. Postsynaptic density membrane {ECO:0000250|UniProtKB:O88951}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Cell junction, tight junction {ECO:0000250|UniProtKB:O88951}. Note=Mainly basolateral in renal epithelial cells. {ECO:0000269|PubMed:11742811}.
Q9HAQ2	reviewed	KIF9_HUMAN	Kinesin-like protein KIF9	KIF9	Homo sapiens (Human)	790	FUNCTION: Essential for normal male fertility and for progressive motility of spermatozoa. {ECO:0000250|UniProtKB:Q9WV04}.		extracellular matrix disassembly [GO:0022617]; microtubule-based movement [GO:0007018]; organelle disassembly [GO:1903008]; regulation of flagellated sperm motility [GO:1901317]; regulation of podosome assembly [GO:0071801]	cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; podosome [GO:0002102]; sperm flagellum [GO:0036126]; vesicle [GO:0031982]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; podosome [GO:0002102]; sperm flagellum [GO:0036126]; vesicle [GO:0031982]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; extracellular matrix disassembly [GO:0022617]; microtubule-based movement [GO:0007018]; organelle disassembly [GO:1903008]; regulation of flagellated sperm motility [GO:1901317]; regulation of podosome assembly [GO:0071801]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9WV04}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9WV04}.
Q9HAR2	reviewed	AGRL3_HUMAN	Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3)	ADGRL3 KIAA0768 LEC3 LPHN3	Homo sapiens (Human)	1447	FUNCTION: Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. {ECO:0000250|UniProtKB:Q80TS3, ECO:0000305|PubMed:26235030}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; G protein-coupled receptor signaling pathway [GO:0007186]; neuron migration [GO:0001764]; synapse assembly [GO:0007416]	axon [GO:0030424]; cell-cell junction [GO:0005911]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G protein-coupled receptor activity [GO:0004930]	axon [GO:0030424]; cell-cell junction [GO:0005911]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; G protein-coupled receptor signaling pathway [GO:0007186]; neuron migration [GO:0001764]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26235030}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q80TS3}. Cell junction {ECO:0000250|UniProtKB:Q80TS3}.
Q9HAS0	reviewed	NJMU_HUMAN	Protein Njmu-R1	C17orf75	Homo sapiens (Human)	396	FUNCTION: As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis. {ECO:0000269|PubMed:29426865}.		intracellular protein transport [GO:0006886]; vesicle tethering to Golgi [GO:0099041]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802]		cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802]; intracellular protein transport [GO:0006886]; vesicle tethering to Golgi [GO:0099041]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:29426865}. Cytoplasmic vesicle {ECO:0000269|PubMed:29426865}.
Q9HAS3	reviewed	S28A3_HUMAN	Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (hCNT3)	SLC28A3 CNT3	Homo sapiens (Human)	691	FUNCTION: Sodium-dependent, pyrimidine- and purine-selective (PubMed:11032837, PubMed:15861042, PubMed:16446384, PubMed:17140564, PubMed:21998139). Involved in the homeostasis of endogenous nucleosides (PubMed:11032837, PubMed:15861042). Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine) (PubMed:11032837). Employs a 2:1 sodium/nucleoside ratio (PubMed:11032837). Transports uridine (PubMed:21795683). Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (PubMed:11032837, PubMed:17140564). {ECO:0000269|PubMed:11032837, ECO:0000269|PubMed:15861042, ECO:0000269|PubMed:16446384, ECO:0000269|PubMed:17140564, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:21998139}.	MISCELLANEOUS: [Isoform 2]: Exhibits a shorter half-life than isoform 1, degraded via a proteasome-dependent pathway. {ECO:0000305}.	nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; pyrimidine-containing compound transmembrane transport [GO:0072531]; uridine transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]	brush border membrane [GO:0031526]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213]	brush border membrane [GO:0031526]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213]; nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; pyrimidine-containing compound transmembrane transport [GO:0072531]; uridine transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:21998139}; Multi-pass membrane protein {ECO:0000269|PubMed:32776918}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18827020}; Multi-pass membrane protein {ECO:0000269|PubMed:32776918}.
Q9HAT0	reviewed	ROP1A_HUMAN	Ropporin-1A (Cancer/testis antigen 91) (CT91) (Rhophilin-associated protein 1A)	ROPN1 ROPN1A	Homo sapiens (Human)	212	FUNCTION: Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. {ECO:0000250|UniProtKB:Q9ESG2}.	MISCELLANEOUS: 'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.	cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; protein localization to cilium [GO:0061512]; regulation of protein phosphorylation [GO:0001932]; sperm capacitation [GO:0048240]	cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; protein localization to cilium [GO:0061512]; regulation of protein phosphorylation [GO:0001932]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9ESG2}. Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath. {ECO:0000250|UniProtKB:Q9ESG2}.
Q9HAT2	reviewed	SIAE_HUMAN	Sialate O-acetylesterase (EC 3.1.1.53) (H-Lse) (Sialic acid-specific 9-O-acetylesterase)	SIAE YSG2	Homo sapiens (Human)	523	FUNCTION: Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.		carbohydrate metabolic process [GO:0005975]; regulation of immune system process [GO:0002682]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosome [GO:0005764]	sialate 4-O-acetylesterase activity [GO:0106331]; sialate 9-O-acetylesterase activity [GO:0106330]; sialate O-acetylesterase activity [GO:0001681]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosome [GO:0005764]; sialate 4-O-acetylesterase activity [GO:0106331]; sialate 9-O-acetylesterase activity [GO:0106330]; sialate O-acetylesterase activity [GO:0001681]; carbohydrate metabolic process [GO:0005975]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Lysosome {ECO:0000305}. Secreted.
Q9HAT8	reviewed	PELI2_HUMAN	E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 2)	PELI2	Homo sapiens (Human)	420	FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. {ECO:0000269|PubMed:12804775, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:22669975}.		positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; regulation of Toll signaling pathway [GO:0008592]	cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; regulation of Toll signaling pathway [GO:0008592]	
Q9HAU0	reviewed	PKHA5_HUMAN	Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)	PLEKHA5 KIAA1686 PEPP2	Homo sapiens (Human)	1116		MISCELLANEOUS: [Isoform 6]: Specifically expressed in brain. {ECO:0000305}.	reproductive system development [GO:0061458]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]	phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; reproductive system development [GO:0061458]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22037487}.
Q9HAU4	reviewed	SMUF2_HUMAN	E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)	SMURF2	Homo sapiens (Human)	748	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11016919). Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling (PubMed:11163210, PubMed:12717440, PubMed:21791611). In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1 (PubMed:18448069). Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation (PubMed:11016919, PubMed:11158580, PubMed:11389444). SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation (PubMed:11389444). Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation (PubMed:30696809). {ECO:0000269|PubMed:11016919, ECO:0000269|PubMed:11158580, ECO:0000269|PubMed:11163210, ECO:0000269|PubMed:11389444, ECO:0000269|PubMed:12717440, ECO:0000269|PubMed:18448069, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:30696809}.; FUNCTION: (Microbial infection) In case of filoviruses Ebola/EBOV and Marburg/MARV infection, the complex formed by viral matrix protein VP40 and SMURF2 facilitates virus budding. {ECO:0000269|PubMed:33673144}.		negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of trophoblast cell migration [GO:1901165]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	identical protein binding [GO:0042802]; SMAD binding [GO:0046332]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; identical protein binding [GO:0042802]; SMAD binding [GO:0046332]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of trophoblast cell migration [GO:1901165]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12717440}. Cytoplasm {ECO:0000269|PubMed:12717440}. Cell membrane {ECO:0000269|PubMed:12717440}. Membrane raft {ECO:0000269|PubMed:12717440}. Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts.
Q9HAU5	reviewed	RENT2_HUMAN	Regulator of nonsense transcripts 2 (Up-frameshift suppressor 2 homolog) (hUpf2)	UPF2 KIAA1408 RENT2	Homo sapiens (Human)	1272	FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:18066079}.		animal organ regeneration [GO:0031100]; liver development [GO:0001889]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]	RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]; animal organ regeneration [GO:0031100]; liver development [GO:0001889]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11073994, ECO:0000269|PubMed:11113196, ECO:0000269|PubMed:11163187}. Cytoplasm {ECO:0000250|UniProtKB:A2AT37}.
Q9HAU8	reviewed	RNPL1_HUMAN	Aminopeptidase RNPEPL1 (EC 3.4.11.-) (Arginyl aminopeptidase-like 1) (Methionyl aminopeptidase) (EC 3.4.11.18)	RNPEPL1	Homo sapiens (Human)	725	FUNCTION: Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine. {ECO:0000269|PubMed:19508204}.		proteolysis [GO:0006508]		initiator methionyl aminopeptidase activity [GO:0004239]; metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270]	initiator methionyl aminopeptidase activity [GO:0004239]; metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]	
Q9HAV0	reviewed	GBB4_HUMAN	Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)	GNB4	Homo sapiens (Human)	340	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.		G protein-coupled receptor signaling pathway [GO:0007186]; substantia nigra development [GO:0021762]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]	protein-containing complex binding [GO:0044877]; signaling receptor complex adaptor activity [GO:0030159]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; protein-containing complex binding [GO:0044877]; signaling receptor complex adaptor activity [GO:0030159]; G protein-coupled receptor signaling pathway [GO:0007186]; substantia nigra development [GO:0021762]	
Q9HAV4	reviewed	XPO5_HUMAN	Exportin-5 (Exp5) (Ran-binding protein 21)	XPO5 KIAA1291 RANBP21	Homo sapiens (Human)	1204	FUNCTION: Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.; FUNCTION: Mediates the nuclear export of micro-RNA precursors, which form short hairpins (PubMed:14681208, PubMed:14631048, PubMed:15613540). Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs (PubMed:19965479). Binding is dependent on Ran-GTP (PubMed:19965479). {ECO:0000269|PubMed:14631048, ECO:0000269|PubMed:14681208, ECO:0000269|PubMed:15613540, ECO:0000269|PubMed:19965479}.; FUNCTION: (Microbial infection) Mediates the nuclear export of adenovirus VA1 dsRNA. {ECO:0000269|PubMed:12509441}.		miRNA metabolic process [GO:0010586]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; RNA export from nucleus [GO:0006405]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RISC complex [GO:0016442]; RNA nuclear export complex [GO:0042565]	mRNA binding [GO:0003729]; nuclear export signal receptor activity [GO:0005049]; pre-miRNA binding [GO:0070883]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RISC complex [GO:0016442]; RNA nuclear export complex [GO:0042565]; mRNA binding [GO:0003729]; nuclear export signal receptor activity [GO:0005049]; pre-miRNA binding [GO:0070883]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; tRNA binding [GO:0000049]; miRNA metabolic process [GO:0010586]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; RNA export from nucleus [GO:0006405]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11777942}. Cytoplasm {ECO:0000269|PubMed:11777942}. Note=Shuttles between the nucleus and the cytoplasm.
Q9HAV5	reviewed	TNR27_HUMAN	Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor)	EDA2R TNFRSF27 XEDAR UNQ2448/PRO5727/PRO34080	Homo sapiens (Human)	297	FUNCTION: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. {ECO:0000269|PubMed:12270937}.		ectodermal cell differentiation [GO:0010668]; epidermis development [GO:0008544]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]	membrane [GO:0016020]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]; tumor necrosis factor receptor activity [GO:0005031]	membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; tumor necrosis factor receptor activity [GO:0005031]; ectodermal cell differentiation [GO:0010668]; epidermis development [GO:0008544]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]	SUBCELLULAR LOCATION: Membrane; Single-pass type III membrane protein.
Q9HAV7	reviewed	GRPE1_HUMAN	GrpE protein homolog 1, mitochondrial (HMGE) (Mt-GrpE#1)	GRPEL1 GREPEL1	Homo sapiens (Human)	217	FUNCTION: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (PubMed:11311562). {ECO:0000250|UniProtKB:P38523, ECO:0000269|PubMed:11311562}.		intracellular protein transport [GO:0006886]; protein folding [GO:0006457]; protein import into mitochondrial matrix [GO:0030150]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	adenyl-nucleotide exchange factor activity [GO:0000774]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; adenyl-nucleotide exchange factor activity [GO:0000774]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; intracellular protein transport [GO:0006886]; protein folding [GO:0006457]; protein import into mitochondrial matrix [GO:0030150]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:11311562}.
Q9HAW0	reviewed	BRF2_HUMAN	Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU)	BRF2 BRFU PRO1470	Homo sapiens (Human)	419	FUNCTION: General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269|PubMed:11040218, ECO:0000269|PubMed:11121026, ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:26638071}.		cellular response to oxidative stress [GO:0034599]; DNA-templated transcription initiation [GO:0006352]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription preinitiation complex assembly [GO:0070897]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIIB complex [GO:0000126]; transcription preinitiation complex [GO:0097550]	metal ion binding [GO:0046872]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TBP-class protein binding [GO:0017025]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIIB complex [GO:0000126]; transcription preinitiation complex [GO:0097550]; metal ion binding [GO:0046872]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TBP-class protein binding [GO:0017025]; cellular response to oxidative stress [GO:0034599]; DNA-templated transcription initiation [GO:0006352]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription preinitiation complex assembly [GO:0070897]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17505538}.
Q9HAW4	reviewed	CLSPN_HUMAN	Claspin (hClaspin)	CLSPN	Homo sapiens (Human)	1339	FUNCTION: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15707391, PubMed:15096610, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:35585232, PubMed:34694004). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}.		activation of protein kinase activity [GO:0032147]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; peptidyl-serine phosphorylation [GO:0018105]	Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	anaphase-promoting complex binding [GO:0010997]; DNA secondary structure binding [GO:0000217]	Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; anaphase-promoting complex binding [GO:0010997]; DNA secondary structure binding [GO:0000217]; activation of protein kinase activity [GO:0032147]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; peptidyl-serine phosphorylation [GO:0018105]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12766152}.
Q9HAW7	reviewed	UD17_HUMAN	UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G)	UGT1A7 GNT1 UGT1	Homo sapiens (Human)	530	FUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15470161, PubMed:18052087, PubMed:18004212, PubMed:18674515, PubMed:18719240, PubMed:20610558, PubMed:23360619). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol (PubMed:18719240). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558, PubMed:23360619). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161). {ECO:0000269|PubMed:12181437, ECO:0000269|PubMed:15470161, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18052087, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:20610558, ECO:0000269|PubMed:23360619}.; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558, ECO:0000269|PubMed:23360619}.	MISCELLANEOUS: UGT1A7 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity. {ECO:0000269|PubMed:18004212}.	cellular glucuronidation [GO:0052695]; coumarin metabolic process [GO:0009804]; estrogen metabolic process [GO:0008210]; fatty acid metabolic process [GO:0006631]; flavone metabolic process [GO:0051552]; flavonoid glucuronidation [GO:0052696]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; retinoic acid metabolic process [GO:0042573]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; retinoic acid binding [GO:0001972]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; retinoic acid binding [GO:0001972]; cellular glucuronidation [GO:0052695]; coumarin metabolic process [GO:0009804]; estrogen metabolic process [GO:0008210]; fatty acid metabolic process [GO:0006631]; flavone metabolic process [GO:0051552]; flavonoid glucuronidation [GO:0052696]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; retinoic acid metabolic process [GO:0042573]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17179145}; Single-pass membrane protein {ECO:0000255}.
Q9HAW8	reviewed	UD110_HUMAN	UDP-glucuronosyltransferase 1A10 (UGT1A10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-10) (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J)	UGT1A10 GNT1 UGT1	Homo sapiens (Human)	530	FUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867, PubMed:26220143). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:18719240, PubMed:23288867, PubMed:26220143). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515). {ECO:0000269|PubMed:12181437, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18052087, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19545173, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:26220143}.; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558}.	MISCELLANEOUS: UGT1A10 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity. {ECO:0000269|PubMed:18004212}.	cellular glucuronidation [GO:0052695]; flavone metabolic process [GO:0051552]; lipid metabolic process [GO:0006629]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; cellular glucuronidation [GO:0052695]; flavone metabolic process [GO:0051552]; lipid metabolic process [GO:0006629]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17179145}; Single-pass membrane protein {ECO:0000255}.
Q9HAW9	reviewed	UD18_HUMAN	UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H)	UGT1A8 GNT1 UGT1	Homo sapiens (Human)	530	FUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:16595710, PubMed:18052087, PubMed:18004212, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15472229, PubMed:16595710, PubMed:23288867). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens (PubMed:15472229, PubMed:16595710, PubMed:18719240, PubMed:23288867). Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps (PubMed:16595710). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212). {ECO:0000269|PubMed:15470161, ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:16595710, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18052087, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19545173, ECO:0000269|PubMed:23288867}.; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558}.	MISCELLANEOUS: UGT1A8 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity. {ECO:0000269|PubMed:18004212}.	cellular glucuronidation [GO:0052695]; coumarin metabolic process [GO:0009804]; fatty acid metabolic process [GO:0006631]; flavone metabolic process [GO:0051552]; flavonoid glucuronidation [GO:0052696]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; negative regulation of steroid metabolic process [GO:0045939]; retinoic acid metabolic process [GO:0042573]; steroid metabolic process [GO:0008202]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; fatty acid binding [GO:0005504]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]; steroid binding [GO:0005496]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; fatty acid binding [GO:0005504]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]; steroid binding [GO:0005496]; cellular glucuronidation [GO:0052695]; coumarin metabolic process [GO:0009804]; fatty acid metabolic process [GO:0006631]; flavone metabolic process [GO:0051552]; flavonoid glucuronidation [GO:0052696]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; negative regulation of steroid metabolic process [GO:0045939]; retinoic acid metabolic process [GO:0042573]; steroid metabolic process [GO:0008202]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17179145}; Single-pass membrane protein {ECO:0000255}.
Q9HAY6	reviewed	BCDO1_HUMAN	Beta,beta-carotene 15,15'-dioxygenase (EC 1.13.11.63) (Beta-carotene dioxygenase 1) (Beta-carotene oxygenase 1)	BCO1 BCDO BCDO1 BCMO1	Homo sapiens (Human)	547	FUNCTION: Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. {ECO:0000269|PubMed:11401432, ECO:0000269|PubMed:17951468, ECO:0000269|PubMed:24668807}.		beta-carotene metabolic process [GO:1901810]; carotene catabolic process [GO:0016121]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; vitamin A biosynthetic process [GO:0035238]	cytosol [GO:0005829]	beta-carotene 15,15'-dioxygenase activity [GO:0003834]; carotenoid dioxygenase activity [GO:0010436]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; beta-carotene 15,15'-dioxygenase activity [GO:0003834]; carotenoid dioxygenase activity [GO:0010436]; metal ion binding [GO:0046872]; beta-carotene metabolic process [GO:1901810]; carotene catabolic process [GO:0016121]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; vitamin A biosynthetic process [GO:0035238]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9I993}.
Q9HAZ1	reviewed	CLK4_HUMAN	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4)	CLK4	Homo sapiens (Human)	481	FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:11170754, ECO:0000269|PubMed:19168442}.		phosphorylation [GO:0016310]; regulation of RNA splicing [GO:0043484]	nucleus [GO:0005634]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; phosphorylation [GO:0016310]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9HAZ2	reviewed	PRD16_HUMAN	Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)	PRDM16 KIAA1675 MEL1 PFM13	Homo sapiens (Human)	1276	FUNCTION: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}.	MISCELLANEOUS: [Isoform 4]: Produced by alternative promoter usage. {ECO:0000305}.	brown fat cell differentiation [GO:0050873]; heterochromatin organization [GO:0070828]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cellular respiration [GO:0043457]; regulation of transcription by RNA polymerase II [GO:0006357]	aggresome [GO:0016235]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	aggresome [GO:0016235]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; brown fat cell differentiation [GO:0050873]; heterochromatin organization [GO:0070828]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cellular respiration [GO:0043457]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19049980}. Cytoplasm {ECO:0000269|PubMed:22939622}.
Q9HB03	reviewed	ELOV3_HUMAN	Elongation of very long chain fatty acids protein 3 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL3) (Cold-inducible glycoprotein of 30 kDa) (ELOVL fatty acid elongase 3) (ELOVL FA elongase 3) (Very long chain 3-ketoacyl-CoA synthase 3) (Very long chain 3-oxoacyl-CoA synthase 3)	ELOVL3 CIG30	Homo sapiens (Human)	270	FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03203, ECO:0000269|PubMed:20937905}.		alpha-linolenic acid metabolic process [GO:0036109]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; linoleic acid metabolic process [GO:0043651]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cold-induced thermogenesis [GO:0120162]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	fatty acid elongase activity [GO:0009922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fatty acid elongase activity [GO:0009922]; alpha-linolenic acid metabolic process [GO:0036109]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; linoleic acid metabolic process [GO:0043651]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cold-induced thermogenesis [GO:0120162]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03203, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03203}.
Q9HB07	reviewed	MYG1_HUMAN	MYG1 exonuclease (EC 3.1.-.-)	MYG1 C12orf10	Homo sapiens (Human)	376	FUNCTION: 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}.		locomotory exploration behavior [GO:0035641]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclease activity [GO:0004518]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclease activity [GO:0004518]; locomotory exploration behavior [GO:0035641]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:19014353, ECO:0000269|PubMed:20377893}. Mitochondrion matrix {ECO:0000269|PubMed:19014353, ECO:0000269|PubMed:20377893}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JK81}.
Q9HB19	reviewed	PKHA2_HUMAN	Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2)	PLEKHA2 TAPP2	Homo sapiens (Human)	425	FUNCTION: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}.		positive regulation of cell-matrix adhesion [GO:0001954]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; lipid binding [GO:0008289]; PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; lipid binding [GO:0008289]; PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; positive regulation of cell-matrix adhesion [GO:0001954]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000250}.
Q9HB20	reviewed	PKHA3_HUMAN	Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1)	PLEKHA3 FAPP1	Homo sapiens (Human)	300	FUNCTION: Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}.		endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]	identical protein binding [GO:0042802]; phosphatidylinositol-4-phosphate binding [GO:0070273]	cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; identical protein binding [GO:0042802]; phosphatidylinositol-4-phosphate binding [GO:0070273]; endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15107860}; Peripheral membrane protein {ECO:0000269|PubMed:15107860}. Note=Localizes to ER-trans Golgi network (TGN) contacts sites. {ECO:0000269|PubMed:30659099}.
Q9HB21	reviewed	PKHA1_HUMAN	Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1)	PLEKHA1 TAPP1	Homo sapiens (Human)	404	FUNCTION: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:11513726, ECO:0000269|PubMed:14516276}.		androgen metabolic process [GO:0008209]; B cell receptor signaling pathway [GO:0050853]; cellular response to hydrogen peroxide [GO:0070301]; establishment of protein localization [GO:0045184]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; multicellular organism growth [GO:0035264]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; roof of mouth development [GO:0060021]; ruffle organization [GO:0031529]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	lipid binding [GO:0008289]; PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; lipid binding [GO:0008289]; PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; androgen metabolic process [GO:0008209]; B cell receptor signaling pathway [GO:0050853]; cellular response to hydrogen peroxide [GO:0070301]; establishment of protein localization [GO:0045184]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; multicellular organism growth [GO:0035264]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; roof of mouth development [GO:0060021]; ruffle organization [GO:0031529]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}. Cell membrane {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}; Peripheral membrane protein. Nucleus {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000269|PubMed:11802782}.
Q9HB29	reviewed	ILRL2_HUMAN	Interleukin-1 receptor-like 2 (EC 3.2.2.6) (IL-36 receptor) (IL-36R) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2)	IL1RL2 IL1RRP2	Homo sapiens (Human)	575	FUNCTION: Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. {ECO:0000250|UniProtKB:Q9ERS7, ECO:0000269|PubMed:11466363}.		cellular defense response [GO:0006968]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of T cell differentiation [GO:0045582]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	interleukin-1 receptor activity [GO:0004908]; interleukin-1, type I, activating receptor activity [GO:0004909]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]	plasma membrane [GO:0005886]; interleukin-1 receptor activity [GO:0004908]; interleukin-1, type I, activating receptor activity [GO:0004909]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; cellular defense response [GO:0006968]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of T cell differentiation [GO:0045582]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:24829417}.
Q9HB55	reviewed	CP343_HUMAN	Cytochrome P450 3A43 (EC 1.14.14.1)	CYP3A43	Homo sapiens (Human)	503	FUNCTION: Exhibits low testosterone 6-beta-hydroxylase activity.	MISCELLANEOUS: Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664). {ECO:0000305|PubMed:11726664}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	oxidative demethylation [GO:0070989]; steroid metabolic process [GO:0008202]	endoplasmic reticulum membrane [GO:0005789]	aromatase activity [GO:0070330]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; testosterone 6-beta-hydroxylase activity [GO:0050649]	endoplasmic reticulum membrane [GO:0005789]; aromatase activity [GO:0070330]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; testosterone 6-beta-hydroxylase activity [GO:0050649]; oxidative demethylation [GO:0070989]; steroid metabolic process [GO:0008202]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Q9HB58	reviewed	SP110_HUMAN	Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110)	SP110	Homo sapiens (Human)	689	FUNCTION: Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).		regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00185, ECO:0000255|PROSITE-ProRule:PRU00747, ECO:0000269|PubMed:10913195, ECO:0000269|PubMed:25593309}. Note=Found in the nuclear body. {ECO:0000269|PubMed:10913195}.
Q9HB63	reviewed	NET4_HUMAN	Netrin-4 (Beta-netrin) (Hepar-derived netrin-like protein)	NTN4	Homo sapiens (Human)	628	FUNCTION: May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. {ECO:0000269|PubMed:11038171}.		animal organ morphogenesis [GO:0009887]; basement membrane assembly [GO:0070831]; cell migration [GO:0016477]; neuron remodeling [GO:0016322]; regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling [GO:0060668]; substrate adhesion-dependent cell spreading [GO:0034446]; tissue development [GO:0009888]	extracellular region [GO:0005576]; laminin complex [GO:0043256]; plasma membrane [GO:0005886]	laminin-1 binding [GO:0043237]	extracellular region [GO:0005576]; laminin complex [GO:0043256]; plasma membrane [GO:0005886]; laminin-1 binding [GO:0043237]; animal organ morphogenesis [GO:0009887]; basement membrane assembly [GO:0070831]; cell migration [GO:0016477]; neuron remodeling [GO:0016322]; regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling [GO:0060668]; substrate adhesion-dependent cell spreading [GO:0034446]; tissue development [GO:0009888]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:11038171}. Note=Major component.
Q9HB65	reviewed	ELL3_HUMAN	RNA polymerase II elongation factor ELL3	ELL3	Homo sapiens (Human)	397	FUNCTION: Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). {ECO:0000250, ECO:0000269|PubMed:10882741, ECO:0000269|PubMed:22195968}.		DNA-templated transcription elongation [GO:0006354]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; neural precursor cell proliferation [GO:0061351]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of epithelial to mesenchymal transition [GO:0010717]; snRNA transcription by RNA polymerase II [GO:0042795]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]	cell junction [GO:0030054]; chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023]	cis-regulatory region sequence-specific DNA binding [GO:0000987]	cell junction [GO:0030054]; chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-templated transcription elongation [GO:0006354]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; neural precursor cell proliferation [GO:0061351]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of epithelial to mesenchymal transition [GO:0010717]; snRNA transcription by RNA polymerase II [GO:0042795]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10882741}.
Q9HB71	reviewed	CYBP_HUMAN	Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein)	CACYBP S100A6BP SIP PNAS-107	Homo sapiens (Human)	228	FUNCTION: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}.		cellular response to leukemia inhibitory factor [GO:1990830]; heart development [GO:0007507]	beta-catenin destruction complex [GO:0030877]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear envelope lumen [GO:0005641]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]; tubulin binding [GO:0015631]; ubiquitin protein ligase binding [GO:0031625]	beta-catenin destruction complex [GO:0030877]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear envelope lumen [GO:0005641]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]; tubulin binding [GO:0015631]; ubiquitin protein ligase binding [GO:0031625]; cellular response to leukemia inhibitory factor [GO:1990830]; heart development [GO:0007507]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12895292}. Cytoplasm {ECO:0000269|PubMed:12895292}. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
Q9HB75	reviewed	PIDD1_HUMAN	p53-induced death domain-containing protein 1 (EC 3.4.21.-) (Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC]	PIDD1 LRDD PIDD	Homo sapiens (Human)	910	FUNCTION: Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264, PubMed:15073321, PubMed:16360037, PubMed:17159900). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:17159900). Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (PubMed:16360037, PubMed:17159900). {ECO:0000269|PubMed:10973264, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:16360037, ECO:0000269|PubMed:17159900}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoprocessing [GO:0016540]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	death receptor binding [GO:0005123]; endopeptidase activity [GO:0004175]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; death receptor binding [GO:0005123]; endopeptidase activity [GO:0004175]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoprocessing [GO:0016540]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16360037, ECO:0000269|PubMed:17159900}. Nucleus {ECO:0000269|PubMed:16360037, ECO:0000269|PubMed:17159900}. Note=Enriched in the nucleus upon DNA damage. {ECO:0000269|PubMed:17159900}.
Q9HB89	reviewed	NMUR1_HUMAN	Neuromedin-U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G-protein coupled receptor FM-3)	NMUR1 GPR66	Homo sapiens (Human)	426	FUNCTION: Receptor for the neuromedin-U and neuromedin-S neuropeptides. {ECO:0000250, ECO:0000269|PubMed:10899166}.		calcium-mediated signaling [GO:0019722]; chloride transport [GO:0006821]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium-mediated signaling [GO:0050850]; smooth muscle contraction [GO:0006939]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; neuromedin U binding [GO:0042924]; neuromedin U receptor activity [GO:0001607]; neuropeptide receptor activity [GO:0008188]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuromedin U binding [GO:0042924]; neuromedin U receptor activity [GO:0001607]; neuropeptide receptor activity [GO:0008188]; calcium-mediated signaling [GO:0019722]; chloride transport [GO:0006821]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium-mediated signaling [GO:0050850]; smooth muscle contraction [GO:0006939]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9HB90	reviewed	RRAGC_HUMAN	Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929)	RRAGC	Homo sapiens (Human)	399	FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:31601764, PubMed:31601708, PubMed:32612235, PubMed:36697823). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279, PubMed:32868926, PubMed:31601764, PubMed:31601708). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:32612235, PubMed:32612235, PubMed:36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279, PubMed:27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235, PubMed:36697823). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:27234373, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:36697823}.		apoptotic process [GO:0006915]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to nutrient levels [GO:0031669]; cellular response to starvation [GO:0009267]; DNA-templated transcription [GO:0006351]; negative regulation of autophagy [GO:0010507]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; protein localization to lysosome [GO:0061462]; protein localization to membrane [GO:0072657]; regulation of TOR signaling [GO:0032006]; regulation of TORC1 signaling [GO:1903432]; response to amino acid [GO:0043200]; RNA splicing [GO:0008380]; small GTPase mediated signal transduction [GO:0007264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; Gtr1-Gtr2 GTPase complex [GO:1990131]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	enzyme-substrate adaptor activity [GO:0140767]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; magnesium ion binding [GO:0000287]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein-membrane adaptor activity [GO:0043495]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; Gtr1-Gtr2 GTPase complex [GO:1990131]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; enzyme-substrate adaptor activity [GO:0140767]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; magnesium ion binding [GO:0000287]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein-membrane adaptor activity [GO:0043495]; apoptotic process [GO:0006915]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to nutrient levels [GO:0031669]; cellular response to starvation [GO:0009267]; DNA-templated transcription [GO:0006351]; negative regulation of autophagy [GO:0010507]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; protein localization to lysosome [GO:0061462]; protein localization to membrane [GO:0072657]; regulation of TOR signaling [GO:0032006]; regulation of TORC1 signaling [GO:1903432]; response to amino acid [GO:0043200]; RNA splicing [GO:0008380]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11073942}. Nucleus {ECO:0000269|PubMed:11073942}. Lysosome membrane {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:28935770}. Note=Predominantly cytoplasmic (PubMed:11073942). Recruited to the lysosome surface by the Ragulator complex (PubMed:20381137, PubMed:28935770). May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942). {ECO:0000269|PubMed:11073942, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:28935770}.
Q9HB96	reviewed	FANCE_HUMAN	Fanconi anemia group E protein (Protein FACE)	FANCE FACE	Homo sapiens (Human)	536	FUNCTION: As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. {ECO:0000269|PubMed:12093742, ECO:0000269|PubMed:17296736}.		interstrand cross-link repair [GO:0036297]	centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome [GO:0005694]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome [GO:0005694]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; interstrand cross-link repair [GO:0036297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12093742, ECO:0000269|PubMed:17296736}.
Q9HBA0	reviewed	TRPV4_HUMAN	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC)	TRPV4 VRL2 VROAC	Homo sapiens (Human)	871	FUNCTION: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501). {ECO:0000250|UniProtKB:Q9EPK8, ECO:0000269|PubMed:11025659, ECO:0000269|PubMed:12724311, ECO:0000269|PubMed:16293632, ECO:0000269|PubMed:18587396, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:18826956, ECO:0000269|PubMed:19759329, ECO:0000269|PubMed:20037586, ECO:0000269|PubMed:21964574, ECO:0000269|PubMed:25256292, ECO:0000269|PubMed:26249260, ECO:0000269|PubMed:29899501}.; FUNCTION: [Isoform 5]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 2]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 4]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 6]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.	MISCELLANEOUS: [Isoform 2]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; MISCELLANEOUS: [Isoform 4]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; MISCELLANEOUS: [Isoform 5]: Forms active ion channels. {ECO:0000269|PubMed:16293632}.; MISCELLANEOUS: [Isoform 6]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.	actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; blood vessel endothelial cell delamination [GO:0097497]; calcium ion import [GO:0070509]; calcium ion import into cytosol [GO:1902656]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell volume homeostasis [GO:0006884]; cell-cell junction assembly [GO:0007043]; cellular hypotonic response [GO:0071476]; cellular hypotonic salinity response [GO:0071477]; cellular response to heat [GO:0034605]; cellular response to osmotic stress [GO:0071470]; cortical microtubule organization [GO:0043622]; diet induced thermogenesis [GO:0002024]; glucose homeostasis [GO:0042593]; hyperosmotic salinity response [GO:0042538]; intracellular calcium ion homeostasis [GO:0006874]; microtubule polymerization [GO:0046785]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osmosensory signaling pathway [GO:0007231]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage inflammatory protein 1 alpha production [GO:0071642]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of striated muscle contraction [GO:0045989]; positive regulation of vascular permeability [GO:0043117]; regulation of aerobic respiration [GO:1903715]; regulation of response to osmotic stress [GO:0047484]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to mechanical stimulus [GO:0009612]; vasopressin secretion [GO:0030103]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cilium [GO:0005929]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; monoatomic cation channel activity [GO:0005261]; osmosensor activity [GO:0005034]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; SH2 domain binding [GO:0042169]; stretch-activated, monoatomic cation-selective, calcium channel activity [GO:0015275]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cilium [GO:0005929]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; monoatomic cation channel activity [GO:0005261]; osmosensor activity [GO:0005034]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; SH2 domain binding [GO:0042169]; stretch-activated, monoatomic cation-selective, calcium channel activity [GO:0015275]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; blood vessel endothelial cell delamination [GO:0097497]; calcium ion import [GO:0070509]; calcium ion import into cytosol [GO:1902656]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell volume homeostasis [GO:0006884]; cell-cell junction assembly [GO:0007043]; cellular hypotonic response [GO:0071476]; cellular hypotonic salinity response [GO:0071477]; cellular response to heat [GO:0034605]; cellular response to osmotic stress [GO:0071470]; cortical microtubule organization [GO:0043622]; diet induced thermogenesis [GO:0002024]; glucose homeostasis [GO:0042593]; hyperosmotic salinity response [GO:0042538]; intracellular calcium ion homeostasis [GO:0006874]; microtubule polymerization [GO:0046785]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osmosensory signaling pathway [GO:0007231]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage inflammatory protein 1 alpha production [GO:0071642]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of striated muscle contraction [GO:0045989]; positive regulation of vascular permeability [GO:0043117]; regulation of aerobic respiration [GO:1903715]; regulation of response to osmotic stress [GO:0047484]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to mechanical stimulus [GO:0009612]; vasopressin secretion [GO:0030103]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16403833, ECO:0000269|PubMed:29899501}. Apical cell membrane {ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:18826956}; Multi-pass membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9EPK8}. Cell projection, cilium {ECO:0000269|PubMed:18695040}. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum (PubMed:16293632, PubMed:20037587, PubMed:20037588). Localization to the cell membrane is inhibited by WNK kinases (WNK1, WNK2, WNK3 or WNK4) in a kinase-independent mechanism (PubMed:16403833). {ECO:0000269|PubMed:16293632, ECO:0000269|PubMed:16403833, ECO:0000269|PubMed:20037587, ECO:0000269|PubMed:20037588}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:16293632, ECO:0000269|PubMed:21964574, ECO:0000269|PubMed:25256292}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane {ECO:0000269|PubMed:16293632}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum {ECO:0000269|PubMed:16293632}.; SUBCELLULAR LOCATION: [Isoform 4]: Endoplasmic reticulum {ECO:0000269|PubMed:16293632}.; SUBCELLULAR LOCATION: [Isoform 6]: Endoplasmic reticulum {ECO:0000269|PubMed:16293632}.
Q9HBB8	reviewed	CDHR5_HUMAN	Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH)	CDHR5 MUCDHL MUPCDH UNQ2781/PRO7168	Homo sapiens (Human)	845	FUNCTION: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. {ECO:0000269|PubMed:24725409}.		cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; regulation of microvillus length [GO:0032532]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; extracellular exosome [GO:0070062]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	beta-catenin binding [GO:0008013]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; extracellular exosome [GO:0070062]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; regulation of microvillus length [GO:0032532]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}. Cell projection, microvillus membrane {ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}.
Q9HBD1	reviewed	RC3H2_HUMAN	Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)	RC3H2 MNAB RNF164	Homo sapiens (Human)	1191	FUNCTION: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}.		B cell homeostasis [GO:0001782]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; lymph node development [GO:0048535]; multicellular organism growth [GO:0035264]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; post-embryonic development [GO:0009791]; protein polyubiquitination [GO:0000209]; regulation of miRNA metabolic process [GO:2000628]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]; T follicular helper cell differentiation [GO:0061470]; ubiquitin-dependent protein catabolic process [GO:0006511]	cell surface [GO:0009986]; cytoplasmic stress granule [GO:0010494]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; P-body [GO:0000932]	DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; ubiquitin protein ligase activity [GO:0061630]	cell surface [GO:0009986]; cytoplasmic stress granule [GO:0010494]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; P-body [GO:0000932]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; ubiquitin protein ligase activity [GO:0061630]; B cell homeostasis [GO:0001782]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; lymph node development [GO:0048535]; multicellular organism growth [GO:0035264]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; post-embryonic development [GO:0009791]; protein polyubiquitination [GO:0000209]; regulation of miRNA metabolic process [GO:2000628]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]; T follicular helper cell differentiation [GO:0061470]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250}. Note=During stress, such as that induced by arsenite, localizes to cytosolic stress granules. Localization to stress granules, but not to P-bodies, depends upon the RING-type zinc finger. {ECO:0000269|PubMed:20412057}.
Q9HBE1	reviewed	PATZ1_HUMAN	POZ-, AT hook-, and zinc finger-containing protein 1 (BTB/POZ domain zinc finger transcription factor) (Protein kinase A RI subunit alpha-associated protein) (Zinc finger and BTB domain-containing protein 19) (Zinc finger protein 278) (Zinc finger sarcoma gene protein)	PATZ1 PATZ RIAZ ZBTB19 ZNF278 ZSG	Homo sapiens (Human)	687	FUNCTION: Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552). {ECO:0000269|PubMed:10713105, ECO:0000269|PubMed:25755280, ECO:0000269|PubMed:31875552}.; FUNCTION: (Microbial infection) Plays a positive role in viral cDNA synthesis. {ECO:0000269|PubMed:31060775}.		male gonad development [GO:0008584]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cytokine production [GO:0001817]; regulation of DNA-templated transcription [GO:0006355]; regulation of immune system process [GO:0002682]; spermatogenesis [GO:0007283]; T cell differentiation [GO:0030217]	male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin protein ligase binding [GO:0031625]	male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin protein ligase binding [GO:0031625]; male gonad development [GO:0008584]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cytokine production [GO:0001817]; regulation of DNA-templated transcription [GO:0006355]; regulation of immune system process [GO:0002682]; spermatogenesis [GO:0007283]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10713105}.
Q9HBE4	reviewed	IL21_HUMAN	Interleukin-21 (IL-21) (Za11)	IL21	Homo sapiens (Human)	162	FUNCTION: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed:11081504, PubMed:15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity). {ECO:0000250|UniProtKB:Q9ES17, ECO:0000269|PubMed:11081504, ECO:0000269|PubMed:15178704}.		cell maturation [GO:0048469]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; germinal center B cell differentiation [GO:0002314]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; signal transduction [GO:0007165]; T follicular helper cell differentiation [GO:0061470]; tyrosine phosphorylation of STAT protein [GO:0007260]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; interleukin-2 receptor binding [GO:0005134]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; interleukin-2 receptor binding [GO:0005134]; cell maturation [GO:0048469]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; germinal center B cell differentiation [GO:0002314]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; signal transduction [GO:0007165]; T follicular helper cell differentiation [GO:0061470]; tyrosine phosphorylation of STAT protein [GO:0007260]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11081504}.
Q9HBE5	reviewed	IL21R_HUMAN	Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD antigen CD360)	IL21R NILR UNQ3121/PRO10273	Homo sapiens (Human)	538	FUNCTION: This is a receptor for interleukin-21.		cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; natural killer cell activation [GO:0030101]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cytokine receptor activity [GO:0004896]; interleukin-21 receptor activity [GO:0001532]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cytokine receptor activity [GO:0004896]; interleukin-21 receptor activity [GO:0001532]; transmembrane signaling receptor activity [GO:0004888]; cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; natural killer cell activation [GO:0030101]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9HBF4	reviewed	ZFYV1_HUMAN	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1)	ZFYVE1 DFCP1 KIAA1589 TAFF1 ZNFN2A1 PP10436	Homo sapiens (Human)	777	FUNCTION: Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955). {ECO:0000269|PubMed:11256955, ECO:0000269|PubMed:11739631, ECO:0000269|PubMed:30970241, ECO:0000269|PubMed:31293035}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, mediates through binding with non-structural protein 6 (nsp6) the replication organelle-lipid droplet association required to sustain viral replication. {ECO:0000269|PubMed:35551511}.		cellular response to starvation [GO:0009267]; lipid droplet formation [GO:0140042]; macroautophagy [GO:0016236]; positive regulation by host of viral genome replication [GO:0044829]	autophagosome [GO:0005776]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of omegasome membrane [GO:0097629]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]; omegasome [GO:1990462]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site [GO:0000407]	1-phosphatidylinositol binding [GO:0005545]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; zinc ion binding [GO:0008270]	autophagosome [GO:0005776]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of omegasome membrane [GO:0097629]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]; omegasome [GO:1990462]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site [GO:0000407]; 1-phosphatidylinositol binding [GO:0005545]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; zinc ion binding [GO:0008270]; cellular response to starvation [GO:0009267]; lipid droplet formation [GO:0140042]; macroautophagy [GO:0016236]; positive regulation by host of viral genome replication [GO:0044829]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack {ECO:0000269|PubMed:11256955}. Golgi apparatus {ECO:0000269|PubMed:11024279, ECO:0000269|PubMed:11739631, ECO:0000269|PubMed:25876663}. Endoplasmic reticulum {ECO:0000269|PubMed:11024279, ECO:0000269|PubMed:22178386, ECO:0000269|PubMed:25876663, ECO:0000269|PubMed:30970241}. Lipid droplet {ECO:0000269|PubMed:30970241, ECO:0000269|PubMed:31293035}. Preautophagosomal structure {ECO:0000269|PubMed:25876663, ECO:0000269|PubMed:31293035, ECO:0000269|PubMed:33499712}. Mitochondrion {ECO:0000269|PubMed:25876663}. Note=Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955). Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386). During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663). Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241). {ECO:0000269|PubMed:11256955, ECO:0000269|PubMed:22178386, ECO:0000269|PubMed:30970241, ECO:0000269|PubMed:31293035}.
Q9HBG4	reviewed	VPP4_HUMAN	V-type proton ATPase 116 kDa subunit a 4 (V-ATPase 116 kDa isoform a 4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform)	ATP6V0A4 ATP6N1B ATP6N2	Homo sapiens (Human)	840	FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Involved in normal vectorial acid transport into the urine by the kidney (PubMed:10973252, PubMed:12414817). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:10973252, ECO:0000269|PubMed:12414817}.		intracellular pH reduction [GO:0051452]; ossification [GO:0001503]; proton transmembrane transport [GO:1902600]; regulation of pH [GO:0006885]; renal tubular secretion [GO:0097254]; sensory perception of sound [GO:0007605]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; intracellular pH reduction [GO:0051452]; ossification [GO:0001503]; proton transmembrane transport [GO:1902600]; regulation of pH [GO:0006885]; renal tubular secretion [GO:0097254]; sensory perception of sound [GO:0007605]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:10973252}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q920R6}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron (PubMed:10973252). Localizes to the basolateral surface of beta-intercalated cells in the cortical collecting ducts of the distal nephron (By similarity). {ECO:0000250|UniProtKB:Q920R6, ECO:0000269|PubMed:10973252}.
Q9HBG6	reviewed	IF122_HUMAN	Intraflagellar transport protein 122 homolog (WD repeat-containing protein 10) (WD repeat-containing protein 140)	IFT122 SPG WDR10 WDR140	Homo sapiens (Human)	1241	FUNCTION: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (PubMed:27932497, PubMed:29220510). Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). {ECO:0000250|UniProtKB:Q6NWV3, ECO:0000269|PubMed:27932497, ECO:0000269|PubMed:29220510}.		camera-type eye morphogenesis [GO:0048593]; cilium assembly [GO:0060271]; embryonic body morphogenesis [GO:0010172]; embryonic forelimb morphogenesis [GO:0035115]; embryonic heart tube development [GO:0035050]; embryonic heart tube left/right pattern formation [GO:0060971]; establishment of protein localization to organelle [GO:0072594]; intraciliary anterograde transport [GO:0035720]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; limb development [GO:0060173]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021914]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; protein localization to cilium [GO:0061512]; signal transduction downstream of smoothened [GO:0007227]	ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle A [GO:0030991]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391]		ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle A [GO:0030991]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391]; camera-type eye morphogenesis [GO:0048593]; cilium assembly [GO:0060271]; embryonic body morphogenesis [GO:0010172]; embryonic forelimb morphogenesis [GO:0035115]; embryonic heart tube development [GO:0035050]; embryonic heart tube left/right pattern formation [GO:0060971]; establishment of protein localization to organelle [GO:0072594]; intraciliary anterograde transport [GO:0035720]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; limb development [GO:0060173]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021914]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; protein localization to cilium [GO:0061512]; signal transduction downstream of smoothened [GO:0007227]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:29220510}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:29220510}. Note=Localizes to photoreceptor connecting cilia. {ECO:0000250|UniProtKB:Q6NWV3}.
Q9HBG7	reviewed	LY9_HUMAN	T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)	LY9 CDABP0070	Homo sapiens (Human)	655	FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). {ECO:0000250|UniProtKB:Q01965, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}.		cell adhesion [GO:0007155]; innate immune response [GO:0045087]; positive regulation of interleukin-17 production [GO:0032740]; T cell activation [GO:0042110]; T-helper 17 cell lineage commitment [GO:0072540]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]		external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; cell adhesion [GO:0007155]; innate immune response [GO:0045087]; positive regulation of interleukin-17 production [GO:0032740]; T cell activation [GO:0042110]; T-helper 17 cell lineage commitment [GO:0072540]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000305}.
Q9HBH0	reviewed	RHOF_HUMAN	Rho-related GTP-binding protein RhoF (Rho family GTPase Rif) (Rho in filopodia)	RHOF ARHF RIF	Homo sapiens (Human)	211	FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.		actin filament organization [GO:0007015]; cell migration [GO:0016477]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton.
Q9HBH1	reviewed	DEFM_HUMAN	Peptide deformylase, mitochondrial (EC 3.5.1.88) (Polypeptide deformylase)	PDF PDF1A	Homo sapiens (Human)	243	FUNCTION: Removes the formyl group from the N-terminal Met of newly synthesized proteins. {ECO:0000269|PubMed:14532271, ECO:0000269|PubMed:15489958, ECO:0000269|PubMed:19236878}.		co-translational protein modification [GO:0043686]; N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; positive regulation of cell population proliferation [GO:0008284]; translation [GO:0006412]	mitochondrion [GO:0005739]	metal ion binding [GO:0046872]; peptide deformylase activity [GO:0042586]	mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; peptide deformylase activity [GO:0042586]; co-translational protein modification [GO:0043686]; N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; positive regulation of cell population proliferation [GO:0008284]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14532271, ECO:0000269|PubMed:15489958}.
Q9HBH5	reviewed	RDH14_HUMAN	Retinol dehydrogenase 14 (EC 1.1.1.300) (Alcohol dehydrogenase PAN2) (Short chain dehydrogenase/reductase family 7C member 4)	RDH14 PAN2 SDR7C4 UNQ529/PRO1072	Homo sapiens (Human)	336	FUNCTION: Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroid. {ECO:0000269|PubMed:12435598}.	MISCELLANEOUS: Shows clear specificity for the pro-S hydrogen on C4 of NADPH and the pro-R hydrogen on C15 of retinols. {ECO:0000250|UniProtKB:Q9ERI6}.	osteoblast differentiation [GO:0001649]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	11-cis-retinol dehydrogenase activity [GO:0102354]; NADP-retinol dehydrogenase activity [GO:0052650]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 11-cis-retinol dehydrogenase activity [GO:0102354]; NADP-retinol dehydrogenase activity [GO:0052650]; osteoblast differentiation [GO:0001649]	
Q9HBH7	reviewed	BEX1_HUMAN	Protein BEX1 (Brain-expressed X-linked protein 1)	BEX1	Homo sapiens (Human)	125	FUNCTION: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). {ECO:0000250|UniProtKB:Q3MKQ2, ECO:0000250|UniProtKB:Q9R224}.		cell differentiation [GO:0030154]; negative regulation of protein ubiquitination [GO:0031397]; nervous system development [GO:0007399]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	molecular function inhibitor activity [GO:0140678]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; molecular function inhibitor activity [GO:0140678]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]; cell differentiation [GO:0030154]; negative regulation of protein ubiquitination [GO:0031397]; nervous system development [GO:0007399]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3MKQ2}. Cytoplasm {ECO:0000250|UniProtKB:Q3MKQ2}. Note=Shuttles between the cytoplasm and the nucleus. Predominantly nuclear. {ECO:0000250|UniProtKB:Q3MKQ2}.
Q9HBH9	reviewed	MKNK2_HUMAN	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)	MKNK2 GPRK7 MNK2	Homo sapiens (Human)	465	FUNCTION: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}.		cell surface receptor signaling pathway [GO:0007166]; cellular response to arsenic-containing substance [GO:0071243]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; hemopoiesis [GO:0030097]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of translation [GO:0006417]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell surface receptor signaling pathway [GO:0007166]; cellular response to arsenic-containing substance [GO:0071243]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; hemopoiesis [GO:0030097]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of translation [GO:0006417]	SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, PML body.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm.
Q9HBI0	reviewed	PARVG_HUMAN	Gamma-parvin	PARVG	Homo sapiens (Human)	331	FUNCTION: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. {ECO:0000250}.		actin cytoskeleton organization [GO:0030036]; cell projection assembly [GO:0030031]; cell-matrix adhesion [GO:0007160]; establishment or maintenance of cell polarity [GO:0007163]; substrate adhesion-dependent cell spreading [GO:0034446]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	actin binding [GO:0003779]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; actin cytoskeleton organization [GO:0030036]; cell projection assembly [GO:0030031]; cell-matrix adhesion [GO:0007160]; establishment or maintenance of cell polarity [GO:0007163]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Constituent of focal adhesions. {ECO:0000250}.
Q9HBI1	reviewed	PARVB_HUMAN	Beta-parvin (Affixin)	PARVB CGI-56	Homo sapiens (Human)	364	FUNCTION: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}.		actin cytoskeleton organization [GO:0030036]; cell projection assembly [GO:0030031]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; lamellipodium assembly [GO:0030032]; substrate adhesion-dependent cell spreading [GO:0034446]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; Z disc [GO:0030018]	actin binding [GO:0003779]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; Z disc [GO:0030018]; actin binding [GO:0003779]; actin cytoskeleton organization [GO:0030036]; cell projection assembly [GO:0030031]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; lamellipodium assembly [GO:0030032]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.
Q9HBI6	reviewed	CP4FB_HUMAN	Cytochrome P450 4F11 (CYPIVF11) (EC 1.14.14.1) (3-hydroxy fatty acids omega-hydroxylase CYP4F11) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) (Phylloquinone omega-hydroxylase CYP4F11) (EC 1.14.14.78)	CYP4F11	Homo sapiens (Human)	524	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:24138531, PubMed:15364545, PubMed:18065749). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15364545, PubMed:18065749, PubMed:24138531). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids (PubMed:18065749, PubMed:19932081). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:24138531). Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed:15364545, PubMed:19932081). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil (PubMed:15364545). {ECO:0000269|PubMed:15364545, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:19932081, ECO:0000269|PubMed:24138531}.		arachidonic acid metabolic process [GO:0019369]; blood coagulation [GO:0007596]; fatty acid metabolic process [GO:0006631]; menaquinone catabolic process [GO:0042361]; omega-hydroxylase P450 pathway [GO:0097267]; oxylipin biosynthetic process [GO:0031408]; phylloquinone catabolic process [GO:0042376]; vitamin K catabolic process [GO:0042377]	endoplasmic reticulum membrane [GO:0005789]	aromatase activity [GO:0070330]; fatty acid binding [GO:0005504]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]	endoplasmic reticulum membrane [GO:0005789]; aromatase activity [GO:0070330]; fatty acid binding [GO:0005504]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; arachidonic acid metabolic process [GO:0019369]; blood coagulation [GO:0007596]; fatty acid metabolic process [GO:0006631]; menaquinone catabolic process [GO:0042361]; omega-hydroxylase P450 pathway [GO:0097267]; oxylipin biosynthetic process [GO:0031408]; phylloquinone catabolic process [GO:0042376]; vitamin K catabolic process [GO:0042377]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18065749}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000269|PubMed:18065749}; Single-pass membrane protein {ECO:0000305}.
Q9HBJ8	reviewed	CLTRN_HUMAN	Collectrin (Transmembrane protein 27)	CLTRN TMEM27 UNQ679/PRO1312	Homo sapiens (Human)	222	FUNCTION: Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function (PubMed:16330323). Stimulator of beta cell replication (PubMed:16330323). {ECO:0000250|UniProtKB:Q9ESG4, ECO:0000269|PubMed:16330323}.		calcium-ion regulated exocytosis [GO:0017156]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; positive regulation of amino acid transport [GO:0051957]; positive regulation of L-proline import across plasma membrane [GO:1905737]; regulation of transmembrane transporter activity [GO:0022898]; SNARE complex assembly [GO:0035493]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	protein homodimerization activity [GO:0042803]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]; calcium-ion regulated exocytosis [GO:0017156]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; positive regulation of amino acid transport [GO:0051957]; positive regulation of L-proline import across plasma membrane [GO:1905737]; regulation of transmembrane transporter activity [GO:0022898]; SNARE complex assembly [GO:0035493]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22628310}; Single-pass type I membrane protein {ECO:0000255}. Note=Localizes to the brush border membranes of cells in the proximal tubules of kidney (By similarity). Colocalizes with SLC6A19 in the early proximal S1 tubule (By similarity). {ECO:0000250|UniProtKB:Q9ESG4}.
Q9HBK9	reviewed	AS3MT_HUMAN	Arsenite methyltransferase (EC 2.1.1.137) (Methylarsonite methyltransferase) (S-adenosyl-L-methionine:arsenic(III) methyltransferase)	AS3MT CYT19	Homo sapiens (Human)	375	FUNCTION: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed:16407288, PubMed:25997655). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed:16407288, PubMed:25997655). {ECO:0000269|PubMed:16407288, ECO:0000269|PubMed:25997655}.	MISCELLANEOUS: [Isoform 2]: Devoid of methyltransferase activity. {ECO:0000305}.	arsonoacetate metabolic process [GO:0018872]; methylation [GO:0032259]; toxin metabolic process [GO:0009404]	cytosol [GO:0005829]	arsenite methyltransferase activity [GO:0030791]; methylarsonite methyltransferase activity [GO:0030792]	cytosol [GO:0005829]; arsenite methyltransferase activity [GO:0030791]; methylarsonite methyltransferase activity [GO:0030792]; arsonoacetate metabolic process [GO:0018872]; methylation [GO:0032259]; toxin metabolic process [GO:0009404]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8VHT6}.
Q9HBL0	reviewed	TENS1_HUMAN	Tensin-1 (EC 3.1.3.-)	TNS1 TNS	Homo sapiens (Human)	1839	FUNCTION: May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}.		fibroblast migration [GO:0010761]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]	actin binding [GO:0003779]; metal ion binding [GO:0046872]; phosphoprotein phosphatase activity [GO:0004721]; RNA binding [GO:0003723]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; actin binding [GO:0003779]; metal ion binding [GO:0046872]; phosphoprotein phosphatase activity [GO:0004721]; RNA binding [GO:0003723]; fibroblast migration [GO:0010761]	SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:21768292}. Cell junction, focal adhesion {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:21768292}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21768292}. Note=Localizes to both focal adhesions and fibrillar adhesions (PubMed:20069572). Localized at the cell periphery preferentially to fibrillar adhesions rather than to focal adhesions. Translocates from the cell edge to the cell center in an ITGB1BP1-dependent manner (PubMed:21768292). {ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:21768292}.
Q9HBL8	reviewed	NMRL1_HUMAN	NmrA-like family domain-containing protein 1	NMRAL1 HSCARG	Homo sapiens (Human)	299	FUNCTION: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. {ECO:0000269|PubMed:17496144, ECO:0000269|PubMed:18263583, ECO:0000269|PubMed:19254724}.	MISCELLANEOUS: Reduced levels of NMRAL1 by RNAi increases nitric oxide production and reduces cell viability. Overexpression of NMRAL1 increases cell viability.		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.
Q9HBM0	reviewed	VEZA_HUMAN	Vezatin	VEZT	Homo sapiens (Human)	779	FUNCTION: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. {ECO:0000250|UniProtKB:Q3ZK22}.; FUNCTION: (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. {ECO:0000269|PubMed:15090598}.	MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell-cell adhesion [GO:0098609]	acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; stereocilia ankle link complex [GO:0002142]; stereocilium membrane [GO:0060171]	myosin binding [GO:0017022]	acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; stereocilia ankle link complex [GO:0002142]; stereocilium membrane [GO:0060171]; myosin binding [GO:0017022]; cell-cell adhesion [GO:0098609]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15090598}; Multi-pass membrane protein {ECO:0000305}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q3ZK22}. Cell junction, adherens junction {ECO:0000269|PubMed:15090598}. Nucleus {ECO:0000250|UniProtKB:Q3ZK22}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q3ZK22}.
Q9HBM1	reviewed	SPC25_HUMAN	Kinetochore protein Spc25 (hSpc25)	SPC25 SPBC25 AD024	Homo sapiens (Human)	224	FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:23085020}.		attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]	cytosol [GO:0005829]; kinetochore [GO:0000776]; Ndc80 complex [GO:0031262]; nucleus [GO:0005634]		cytosol [GO:0005829]; kinetochore [GO:0000776]; Ndc80 complex [GO:0031262]; nucleus [GO:0005634]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]	SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:15961401}. Note=Localizes to kinetochores from late prophase to anaphase (PubMed:14738735). Localizes specifically to the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). {ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:14738735}.
Q9HBM6	reviewed	TAF9B_HUMAN	Transcription initiation factor TFIID subunit 9B (Neuronal cell death-related protein 7) (DN-7) (Transcription initiation factor TFIID subunit 9-like) (Transcription-associated factor TAFII31L)	TAF9B TAF9L	Homo sapiens (Human)	251	FUNCTION: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. {ECO:0000269|PubMed:15899866}.		DNA-templated transcription initiation [GO:0006352]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; protein stabilization [GO:0050821]	nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]	protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription corepressor activity [GO:0003714]; DNA-templated transcription initiation [GO:0006352]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9HBR0	reviewed	S38AA_HUMAN	Solute carrier family 38 member 10 (Amino acid transporter SLC38A10)	SLC38A10 PP1744	Homo sapiens (Human)	1119	FUNCTION: Facilitates bidirectional transport of amino acids. May act as a glutamate sensor that regulates glutamate-glutamine cycle and mTOR signaling in the brain. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q5I012}.		amino acid transmembrane transport [GO:0003333]; bone development [GO:0060348]; sodium ion transport [GO:0006814]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	L-amino acid transmembrane transporter activity [GO:0015179]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; L-amino acid transmembrane transporter activity [GO:0015179]; amino acid transmembrane transport [GO:0003333]; bone development [GO:0060348]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9HBT6	reviewed	CAD20_HUMAN	Cadherin-20	CDH20 CDH7L3	Homo sapiens (Human)	801	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	adherens junction [GO:0005912]; catenin complex [GO:0016342]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q9HBT8	reviewed	Z286A_HUMAN	Zinc finger protein 286A	ZNF286A KIAA1874 ZNF286	Homo sapiens (Human)	521	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9HBU1	reviewed	BARX1_HUMAN	Homeobox protein BarH-like 1	BARX1	Homo sapiens (Human)	254	FUNCTION: Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity (By similarity). Binds to a regulatory module of the NCAM promoter. {ECO:0000250, ECO:0000269|PubMed:9804553}.		anterior/posterior pattern specification [GO:0009952]; digestive system development [GO:0055123]; endothelial cell differentiation [GO:0045446]; negative regulation of Wnt signaling pathway [GO:0030178]; regulation of transcription by RNA polymerase II [GO:0006357]; spleen development [GO:0048536]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; anterior/posterior pattern specification [GO:0009952]; digestive system development [GO:0055123]; endothelial cell differentiation [GO:0045446]; negative regulation of Wnt signaling pathway [GO:0030178]; regulation of transcription by RNA polymerase II [GO:0006357]; spleen development [GO:0048536]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9HBU6	reviewed	EKI1_HUMAN	Ethanolamine kinase 1 (EKI 1) (EC 2.7.1.82)	ETNK1 EKI1	Homo sapiens (Human)	452	FUNCTION: Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. {ECO:0000269|PubMed:11044454}.		phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	ATP binding [GO:0005524]; ethanolamine kinase activity [GO:0004305]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; ethanolamine kinase activity [GO:0004305]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:11044454}.
Q9HBV2	reviewed	SACA1_HUMAN	Sperm acrosome membrane-associated protein 1 (Sperm acrosomal membrane-associated protein 32)	SPACA1 SAMP32	Homo sapiens (Human)	294	FUNCTION: Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility (PubMed:11870081). {ECO:0000250|UniProtKB:Q9DA48, ECO:0000269|PubMed:11870081}.		acrosome assembly [GO:0001675]	acrosomal membrane [GO:0002080]; inner acrosomal membrane [GO:0002079]		acrosomal membrane [GO:0002080]; inner acrosomal membrane [GO:0002079]; acrosome assembly [GO:0001675]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane {ECO:0000269|PubMed:11870081}; Single-pass type I membrane protein {ECO:0000305}. Note=Primarily found in the equatorial segment of the acrosome (PubMed:11870081). The tyrosine phosphorylated protein localizes to a smaller region within the equatorial segment (By similarity). Also expressed weakly in the principal segment (PubMed:11870081). {ECO:0000250|UniProtKB:D5K8A9, ECO:0000269|PubMed:11870081}.
Q9HBW0	reviewed	LPAR2_HUMAN	Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4)	LPAR2 EDG4 LPA2	Homo sapiens (Human)	348	FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. {ECO:0000269|PubMed:15143197, ECO:0000269|PubMed:19306925}.	MISCELLANEOUS: PubMed:9525886 cDNA clone has a guanine nucleotide deletion that causes a frameshift near its C-terminal coding region. This likely reflects a somatic mutation in the ovary tumor cells from which the cDNA was isolated and may have altered the function of the encoded receptor, and contributed to transformation of the original ovary cells that formed a tumor.	activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of metabolic process [GO:0019222]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]	G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; lysophosphatidic acid receptor activity [GO:0070915]; PDZ domain binding [GO:0030165]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; lysophosphatidic acid receptor activity [GO:0070915]; PDZ domain binding [GO:0030165]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of metabolic process [GO:0019222]	SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:19306925}. Cell membrane {ECO:0000269|PubMed:19306925}; Multi-pass membrane protein {ECO:0000269|PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
Q9HBW1	reviewed	LRRC4_HUMAN	Leucine-rich repeat-containing protein 4 (Brain tumor-associated protein BAG) (Nasopharyngeal carcinoma-associated gene 14 protein) (Netrin-G2 ligand) (NGL-2)	LRRC4 BAG NAG14 UNQ554/PRO1111	Homo sapiens (Human)	653	FUNCTION: Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). {ECO:0000250}.		excitatory synapse assembly [GO:1904861]; modulation of chemical synaptic transmission [GO:0050804]; postsynaptic density protein 95 clustering [GO:0097119]; synaptic membrane adhesion [GO:0099560]	dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]		dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; excitatory synapse assembly [GO:1904861]; modulation of chemical synaptic transmission [GO:0050804]; postsynaptic density protein 95 clustering [GO:0097119]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Postsynaptic cell membrane {ECO:0000250}. Note=LRRC4 and DLG4 are interdependent for synaptic localization. {ECO:0000250}.
Q9HBW9	reviewed	AGRL4_HUMAN	Adhesion G protein-coupled receptor L4 (EGF, latrophilin and seven transmembrane domain-containing protein 1) (EGF-TM7-latrophilin-related protein) (ETL protein)	ADGRL4 ELTD1 ETL UNQ202/PRO228	Homo sapiens (Human)	690	FUNCTION: Endothelial orphan receptor that acts as a key regulator of angiogenesis. {ECO:0000269|PubMed:23871637}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]	cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23871637}; Multi-pass membrane protein {ECO:0000255}.
Q9HBX8	reviewed	LGR6_HUMAN	Leucine-rich repeat-containing G-protein coupled receptor 6	LGR6 UNQ6427/PRO21331 VTS20631	Homo sapiens (Human)	967	FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:22615920}.		axon guidance [GO:0007411]; bone regeneration [GO:1990523]; G protein-coupled receptor signaling pathway [GO:0007186]; negative chemotaxis [GO:0050919]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt signaling pathway [GO:0016055]	plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982]	heparin binding [GO:0008201]; protein-hormone receptor activity [GO:0016500]; Roundabout binding [GO:0048495]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982]; heparin binding [GO:0008201]; protein-hormone receptor activity [GO:0016500]; Roundabout binding [GO:0048495]; transmembrane signaling receptor activity [GO:0004888]; axon guidance [GO:0007411]; bone regeneration [GO:1990523]; G protein-coupled receptor signaling pathway [GO:0007186]; negative chemotaxis [GO:0050919]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22615920}; Multi-pass membrane protein {ECO:0000269|PubMed:22615920}.
Q9HBX9	reviewed	RXFP1_HUMAN	Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1)	RXFP1 LGR7	Homo sapiens (Human)	757	FUNCTION: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; extracellular matrix organization [GO:0030198]; hormone-mediated signaling pathway [GO:0009755]; lung connective tissue development [GO:0060427]; myofibroblast differentiation [GO:0036446]; nipple morphogenesis [GO:0060658]; parturition [GO:0007567]	plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; metal ion binding [GO:0046872]	plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; metal ion binding [GO:0046872]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; extracellular matrix organization [GO:0030198]; hormone-mediated signaling pathway [GO:0009755]; lung connective tissue development [GO:0060427]; myofibroblast differentiation [GO:0036446]; nipple morphogenesis [GO:0060658]; parturition [GO:0007567]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16051677}; Multi-pass membrane protein {ECO:0000269|PubMed:16051677}.
Q9HBY0	reviewed	NOX3_HUMAN	NADPH oxidase 3 (EC 1.6.3.-) (Mitogenic oxidase 2) (MOX-2) (gp91phox homolog 3) (GP91-3)	NOX3 MOX2	Homo sapiens (Human)	568	FUNCTION: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. {ECO:0000269|PubMed:15824103}.		defense response [GO:0006952]; detection of gravity [GO:0009590]; otolith development [GO:0048840]; superoxide anion generation [GO:0042554]; temperature homeostasis [GO:0001659]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]	superoxide-generating NAD(P)H oxidase activity [GO:0016175]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; defense response [GO:0006952]; detection of gravity [GO:0009590]; otolith development [GO:0048840]; superoxide anion generation [GO:0042554]; temperature homeostasis [GO:0001659]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9HBY8	reviewed	SGK2_HUMAN	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2)	SGK2	Homo sapiens (Human)	367	FUNCTION: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. {ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12632189, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:21865597}.		intracellular signal transduction [GO:0035556]; positive regulation of transporter activity [GO:0032411]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; response to oxidative stress [GO:0006979]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; potassium channel regulator activity [GO:0015459]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; sodium channel regulator activity [GO:0017080]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; potassium channel regulator activity [GO:0015459]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; sodium channel regulator activity [GO:0017080]; intracellular signal transduction [GO:0035556]; positive regulation of transporter activity [GO:0032411]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21865597}. Nucleus {ECO:0000269|PubMed:21865597}.
Q9HBZ2	reviewed	ARNT2_HUMAN	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (Class E basic helix-loop-helix protein 1) (bHLHe1)	ARNT2 BHLHE1 KIAA0307	Homo sapiens (Human)	717	FUNCTION: Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE). {ECO:0000269|PubMed:24022475}.		brain development [GO:0007420]; central nervous system development [GO:0007417]; in utero embryonic development [GO:0001701]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]	aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	aryl hydrocarbon receptor binding [GO:0017162]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; aryl hydrocarbon receptor binding [GO:0017162]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; brain development [GO:0007420]; central nervous system development [GO:0007417]; in utero embryonic development [GO:0001701]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:24465693}.
Q9HC07	reviewed	TM165_HUMAN	Putative divalent cation/proton antiporter TMEM165 (Transmembrane protein 165) (Transmembrane protein PT27) (Transmembrane protein TPARL)	TMEM165 TPARL	Homo sapiens (Human)	324	FUNCTION: Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (PubMed:32047108, PubMed:23569283, PubMed:22683087, PubMed:27008884) (By similarity). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (By similarity). The transport mechanism and stoichiometry remains to be elucidated. {ECO:0000250|UniProtKB:P38301, ECO:0000250|UniProtKB:P52875, ECO:0000269|PubMed:22683087, ECO:0000269|PubMed:23569283, ECO:0000269|PubMed:27008884, ECO:0000269|PubMed:32047108}.		calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; intracellular calcium ion homeostasis [GO:0006874]; manganese ion transmembrane transport [GO:0071421]; manganese ion transport [GO:0006828]; protein N-linked glycosylation [GO:0006487]; regulation of lysosomal lumen pH [GO:0035751]	cis-Golgi network membrane [GO:0033106]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]	calcium ion transmembrane transporter activity [GO:0015085]; manganese ion transmembrane transporter activity [GO:0005384]	cis-Golgi network membrane [GO:0033106]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]; calcium ion transmembrane transporter activity [GO:0015085]; manganese ion transmembrane transporter activity [GO:0005384]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; intracellular calcium ion homeostasis [GO:0006874]; manganese ion transmembrane transport [GO:0071421]; manganese ion transport [GO:0006828]; protein N-linked glycosylation [GO:0006487]; regulation of lysosomal lumen pH [GO:0035751]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:P52875}; Multi-pass membrane protein {ECO:0000255}.
Q9HC10	reviewed	OTOF_HUMAN	Otoferlin (Fer-1-like protein 2)	OTOF FER1L2	Homo sapiens (Human)	1997	FUNCTION: Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity). {ECO:0000250|UniProtKB:Q9ESF1}.		membrane fusion [GO:0061025]; regulation of neurotransmitter secretion [GO:0046928]; sensory perception of sound [GO:0007605]; synaptic vesicle exocytosis [GO:0016079]	basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]	basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; membrane fusion [GO:0061025]; regulation of neurotransmitter secretion [GO:0046928]; sensory perception of sound [GO:0007605]; synaptic vesicle exocytosis [GO:0016079]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9ESF1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9ESF1}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9ESF1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9ESF1}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ESF1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9ESF1}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ESF1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9ESF1}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9ESF1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9ESF1}. Cell membrane {ECO:0000250|UniProtKB:Q9ESF1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9ESF1}. Note=Detected at basolateral cell membrane with synaptic vesicles surrounding the ribbon and at the presynaptic plasma membrane in the inner hair cells (IHCs) at postnatal day 30 (P30). Colocalizes with GPR25 and RAB8B in inner hair cells. {ECO:0000250|UniProtKB:Q9ESF1}.
Q9HC16	reviewed	ABC3G_HUMAN	DNA dC->dU-editing enzyme APOBEC-3G (EC 3.5.4.38) (APOBEC-related cytidine deaminase) (APOBEC-related protein) (ARCD) (APOBEC-related protein 9) (ARP-9) (CEM-15) (CEM15) (Deoxycytidine deaminase) (A3G)	APOBEC3G MDS019	Homo sapiens (Human)	384	FUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against Vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269|PubMed:12167863, ECO:0000269|PubMed:12808465, ECO:0000269|PubMed:12808466, ECO:0000269|PubMed:12809610, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:12970355, ECO:0000269|PubMed:14528300, ECO:0000269|PubMed:14557625, ECO:0000269|PubMed:15031497, ECO:0000269|PubMed:16378963, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:18288108, ECO:0000269|PubMed:19458006, ECO:0000269|PubMed:20219927, ECO:0000269|PubMed:20335265, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:22807680, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:23097438, ECO:0000269|PubMed:23152537}.	MISCELLANEOUS: Accumulation of APOBEC3G induced non-lethal hypermutation could contribute to the genetic variation of primate lentiviral populations.; MISCELLANEOUS: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.; MISCELLANEOUS: [Isoform 3]: May be due to a competing donor splice site. {ECO:0000305}.	base conversion or substitution editing [GO:0016553]; cytidine deamination [GO:0009972]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral process [GO:0048525]; positive regulation of defense response to virus by host [GO:0002230]; retrotransposon silencing [GO:0010526]	apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]	cytidine deaminase activity [GO:0004126]; dCTP deaminase activity [GO:0008829]; deoxycytidine deaminase activity [GO:0047844]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]; cytidine deaminase activity [GO:0004126]; dCTP deaminase activity [GO:0008829]; deoxycytidine deaminase activity [GO:0047844]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; base conversion or substitution editing [GO:0016553]; cytidine deamination [GO:0009972]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral process [GO:0048525]; positive regulation of defense response to virus by host [GO:0002230]; retrotransposon silencing [GO:0010526]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Mainly cytoplasmic. Small amount are found in the nucleus. During HIV-1 infection, virion-encapsidated in absence of HIV-1 Vif.
Q9HC21	reviewed	TPC_HUMAN	Mitochondrial thiamine pyrophosphate carrier (Mitochondrial thiamine pyrophosphate transporter) (MTPPT) (Mitochondrial uncoupling protein 1) (Solute carrier family 25 member 19)	SLC25A19 DNC MUP1	Homo sapiens (Human)	320	FUNCTION: Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient. {ECO:0000269|PubMed:17035501, ECO:0000269|PubMed:18280798, ECO:0000269|PubMed:27188525, ECO:0000269|PubMed:34587972}.		deoxynucleotide transport [GO:0030302]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine pyrophosphate transmembrane transport [GO:0030974]; thiamine-containing compound metabolic process [GO:0042723]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	antiporter activity [GO:0015297]; deoxynucleotide transmembrane transporter activity [GO:0030233]; thiamine pyrophosphate transmembrane transporter activity [GO:0090422]; thiamine transmembrane transporter activity [GO:0015234]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; antiporter activity [GO:0015297]; deoxynucleotide transmembrane transporter activity [GO:0030233]; thiamine pyrophosphate transmembrane transporter activity [GO:0090422]; thiamine transmembrane transporter activity [GO:0015234]; deoxynucleotide transport [GO:0030302]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine pyrophosphate transmembrane transport [GO:0030974]; thiamine-containing compound metabolic process [GO:0042723]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:15539640, ECO:0000269|PubMed:27188525, ECO:0000269|PubMed:31506564}; Multi-pass membrane protein {ECO:0000255}.
Q9HC23	reviewed	PROK2_HUMAN	Prokineticin-2 (PK2) (Protein Bv8 homolog)	PROK2 BV8	Homo sapiens (Human)	129	FUNCTION: May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.		angiogenesis [GO:0001525]; chemotaxis [GO:0006935]; circadian rhythm [GO:0007623]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of smooth muscle contraction [GO:0045987]; sensory perception of pain [GO:0019233]; spermatogenesis [GO:0007283]	extracellular region [GO:0005576]	G protein-coupled receptor binding [GO:0001664]	extracellular region [GO:0005576]; G protein-coupled receptor binding [GO:0001664]; angiogenesis [GO:0001525]; chemotaxis [GO:0006935]; circadian rhythm [GO:0007623]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of smooth muscle contraction [GO:0045987]; sensory perception of pain [GO:0019233]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Secreted.
Q9HC24	reviewed	LFG4_HUMAN	Protein lifeguard 4 (Golgi anti-apoptotic protein) (Protein S1R) (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein)	TMBIM4 GAAP LFG4 CGI-119	Homo sapiens (Human)	238	FUNCTION: Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release. {ECO:0000269|PubMed:17319741, ECO:0000269|PubMed:19553469}.		apoptotic process [GO:0006915]; locomotory behavior [GO:0007626]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of calcium-mediated signaling [GO:0050848]	Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]		Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]; apoptotic process [GO:0006915]; locomotory behavior [GO:0007626]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of calcium-mediated signaling [GO:0050848]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17319741, ECO:0000269|PubMed:22418439}; Multi-pass membrane protein {ECO:0000269|PubMed:17319741, ECO:0000269|PubMed:22418439}.
Q9HC29	reviewed	NOD2_HUMAN	Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1)	NOD2 CARD15	Homo sapiens (Human)	1040	FUNCTION: Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and plays an important role in gastrointestinal immunity (PubMed:12514169, PubMed:12527755, PubMed:12626759, PubMed:15044951, PubMed:15998797, PubMed:27283905, PubMed:27748583, PubMed:31649195). Specifically activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan found in every bacterial peptidoglycan type (PubMed:12514169, PubMed:12871942, PubMed:12527755, PubMed:12626759, PubMed:15044951, PubMed:15998797, PubMed:22857257, PubMed:23322906, PubMed:27748583, PubMed:36002575, PubMed:15198989). NOD2 specifically recognizes and binds 6-O-phospho-MDP, the phosphorylated form of MDP, which is generated by NAGK (PubMed:36002575). 6-O-phospho-MDP-binding triggers oligomerization that facilitates the binding and subsequent activation of the proximal adapter receptor-interacting RIPK2 (PubMed:11087742, PubMed:17355968, PubMed:21887730, PubMed:23806334, PubMed:28436939). Following recruitment, RIPK2 undergoes 'Met-1'- (linear) and 'Lys-63'-linked polyubiquitination by E3 ubiquitin-protein ligases XIAP, BIRC2, BIRC3 and the LUBAC complex, becoming a scaffolding protein for downstream effectors, triggering activation of the NF-kappa-B and MAP kinases signaling (PubMed:11087742, PubMed:12514169, PubMed:12626759, PubMed:21887730, PubMed:23806334, PubMed:23322906, PubMed:28436939, PubMed:15198989). This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (PubMed:15198989). Its ability to detect bacterial MDP plays a central role in maintaining the equilibrium between intestinal microbiota and host immune responses to control inflammation (By similarity). An imbalance in this relationship results in dysbiosis, whereby pathogenic bacteria prevail on commensals, causing damage in the intestinal epithelial barrier as well as allowing bacterial invasion and inflammation (By similarity). Acts as a regulator of appetite by sensing MDP in a subset of brain neurons: microbiota-derived MDP reach the brain, where they bind and activate NOD2 in inhibitory hypothalamic neurons, decreasing neuronal activity, thereby regulating satiety and body temperature (By similarity). NOD2-dependent MDP-sensing of bacterial cell walls in the intestinal epithelial compartment contributes to sustained postnatal growth upon undernutrition (By similarity). Also plays a role in antiviral response by acting as a sensor of single-stranded RNA (ssRNA) from viruses: upon ssRNA-binding, interacts with MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189). Also acts as a regulator of autophagy in dendritic cells via its interaction with ATG16L1, possibly by recruiting ATG16L1 at the site of bacterial entry (PubMed:20637199). NOD2 activation in the small intestine crypt also contributes to intestinal stem cells survival and function: acts by promoting mitophagy via its association with ATG16L1 (By similarity). In addition to its main role in innate immunity, also regulates the adaptive immune system by acting as regulator of helper T-cell and regulatory T-cells (Tregs) (By similarity). Besides recognizing pathogens, also involved in the endoplasmic reticulum stress response: acts by sensing and binding to the cytosolic metabolite sphingosine-1-phosphate generated in response to endoplasmic reticulum stress, initiating an inflammation process that leads to activation of the NF-kappa-B and MAP kinases signaling (PubMed:27007849, PubMed:33942347). May also be involved in NLRP1 activation following activation by MDP, leading to CASP1 activation and IL1B release in macrophages (PubMed:18511561). {ECO:0000250|UniProtKB:Q8K3Z0, ECO:0000269|PubMed:11087742, ECO:0000269|PubMed:12514169, ECO:0000269|PubMed:12527755, ECO:0000269|PubMed:12626759, ECO:0000269|PubMed:12871942, ECO:0000269|PubMed:15044951, ECO:0000269|PubMed:15198989, ECO:0000269|PubMed:15998797, ECO:0000269|PubMed:17355968, ECO:0000269|PubMed:18511561, ECO:0000269|PubMed:19701189, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:22857257, ECO:0000269|PubMed:23322906, ECO:0000269|PubMed:23806334, ECO:0000269|PubMed:27007849, ECO:0000269|PubMed:27283905, ECO:0000269|PubMed:27748583, ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:33942347, ECO:0000269|PubMed:36002575}.; FUNCTION: [Isoform 2]: Acts as a pattern recognition receptor (PRR); able to activate NF-kappa-B. {ECO:0000269|PubMed:11087742}.; FUNCTION: [Isoform 3]: Can activate NF-kappa-B in a muramyl dipeptide (MDP)-independent manner. {ECO:0000269|PubMed:20698950}.	MISCELLANEOUS: [Isoform 1]: Most abundant isoform. {ECO:0000269|PubMed:11087742}.	adaptive immune response [GO:0002250]; biosynthetic process of antibacterial peptides active against Gram-positive bacteria [GO:0002815]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to organic cyclic compound [GO:0071407]; cellular response to peptidoglycan [GO:0071224]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; detection of biotic stimulus [GO:0009595]; detection of muramyl dipeptide [GO:0032498]; ERK1 and ERK2 cascade [GO:0070371]; establishment of localization in cell [GO:0051649]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; intestinal stem cell homeostasis [GO:0036335]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-18 production [GO:0032701]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of T cell mediated immunity [GO:0002710]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; non-canonical NF-kappaB signal transduction [GO:0038061]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; phagocytosis [GO:0006909]; positive regulation of B cell activation [GO:0050871]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria [GO:0006965]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gamma-delta T cell activation [GO:0046645]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mitophagy [GO:1901526]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of oxidoreductase activity [GO:0051353]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of prostaglandin-E synthase activity [GO:2000363]; positive regulation of prostaglandin-endoperoxide synthase activity [GO:0060585]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type 2 immune response [GO:0002830]; positive regulation of xenophagy [GO:1904417]; regulation of appetite [GO:0032098]; regulation of inflammatory response [GO:0050727]; regulation of neutrophil chemotaxis [GO:0090022]; response to endoplasmic reticulum stress [GO:0034976]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to nutrient [GO:0007584]; temperature homeostasis [GO:0001659]; toll-like receptor 2 signaling pathway [GO:0034134]; xenophagy [GO:0098792]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of plasma membrane [GO:0019897]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; vesicle [GO:0031982]	actin binding [GO:0003779]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; CARD domain binding [GO:0050700]; enzyme binding [GO:0019899]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; muramyl dipeptide binding [GO:0032500]; pattern recognition receptor activity [GO:0038187]; peptidoglycan binding [GO:0042834]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of plasma membrane [GO:0019897]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; vesicle [GO:0031982]; actin binding [GO:0003779]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; CARD domain binding [GO:0050700]; enzyme binding [GO:0019899]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; muramyl dipeptide binding [GO:0032500]; pattern recognition receptor activity [GO:0038187]; peptidoglycan binding [GO:0042834]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; adaptive immune response [GO:0002250]; biosynthetic process of antibacterial peptides active against Gram-positive bacteria [GO:0002815]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to organic cyclic compound [GO:0071407]; cellular response to peptidoglycan [GO:0071224]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; detection of biotic stimulus [GO:0009595]; detection of muramyl dipeptide [GO:0032498]; ERK1 and ERK2 cascade [GO:0070371]; establishment of localization in cell [GO:0051649]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; intestinal stem cell homeostasis [GO:0036335]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-18 production [GO:0032701]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of T cell mediated immunity [GO:0002710]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; non-canonical NF-kappaB signal transduction [GO:0038061]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; phagocytosis [GO:0006909]; positive regulation of B cell activation [GO:0050871]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria [GO:0006965]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gamma-delta T cell activation [GO:0046645]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mitophagy [GO:1901526]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of oxidoreductase activity [GO:0051353]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of prostaglandin-E synthase activity [GO:2000363]; positive regulation of prostaglandin-endoperoxide synthase activity [GO:0060585]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type 2 immune response [GO:0002830]; positive regulation of xenophagy [GO:1904417]; regulation of appetite [GO:0032098]; regulation of inflammatory response [GO:0050727]; regulation of neutrophil chemotaxis [GO:0090022]; response to endoplasmic reticulum stress [GO:0034976]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to nutrient [GO:0007584]; temperature homeostasis [GO:0001659]; toll-like receptor 2 signaling pathway [GO:0034134]; xenophagy [GO:0098792]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15998797, ECO:0000269|PubMed:25093298, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:34293401}; Lipid-anchor {ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:34293401}. Basolateral cell membrane {ECO:0000269|PubMed:16203728, ECO:0000269|PubMed:17355968}. Cytoplasm {ECO:0000269|PubMed:14570728, ECO:0000269|PubMed:15998797, ECO:0000269|PubMed:19701189, ECO:0000269|PubMed:24790089, ECO:0000269|PubMed:25093298}. Mitochondrion {ECO:0000269|PubMed:19701189}. Note=Palmitoylation promotes localization to the cell membrane, where it detects bacterial invasion at the point of entry. {ECO:0000269|PubMed:34293401}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:20698950}.
Q9HC35	reviewed	EMAL4_HUMAN	Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120)	EML4 C2orf2 EMAPL4	Homo sapiens (Human)	981	FUNCTION: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}.		attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle [GO:0072686]	alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]; protein self-association [GO:0043621]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]; protein self-association [GO:0043621]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:31409757, ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16890222}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526}. Midbody {ECO:0000269|PubMed:25789526}. Note=Localizes to microtubules (MTs) during interphase with a significantly reduced affinity for MTs during mitosis. {ECO:0000269|PubMed:31409757}.
Q9HC36	reviewed	MRM3_HUMAN	rRNA methyltransferase 3, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1370)-2'-O)-methyltransferase) (16S rRNA [Gm1370] 2'-O-methyltransferase) (RNA methyltransferase-like protein 1)	MRM3 RNMTL1 HC90	Homo sapiens (Human)	420	FUNCTION: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. {ECO:0000269|PubMed:24036117, ECO:0000269|PubMed:25009282, ECO:0000269|PubMed:25074936}.		rRNA 2'-O-methylation [GO:0000451]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA (guanosine-2'-O-)-methyltransferase activity [GO:0070039]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA (guanosine-2'-O-)-methyltransferase activity [GO:0070039]; rRNA 2'-O-methylation [GO:0000451]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:24036117, ECO:0000269|PubMed:25009282}.
Q9HC52	reviewed	CBX8_HUMAN	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)	CBX8 PC3 RC1	Homo sapiens (Human)	389	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}.	MISCELLANEOUS: The human orthologuous proteins of Drosophila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different complexes.	cellular response to hydrogen peroxide [GO:0070301]; chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA repair [GO:0045739]	chromatin [GO:0000785]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]	chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; single-stranded RNA binding [GO:0003727]; ubiquitin-protein transferase activator activity [GO:0097027]	chromatin [GO:0000785]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; single-stranded RNA binding [GO:0003727]; ubiquitin-protein transferase activator activity [GO:0097027]; cellular response to hydrogen peroxide [GO:0070301]; chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA repair [GO:0045739]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530}.
Q9HC58	reviewed	NCKX3_HUMAN	Sodium/potassium/calcium exchanger 3 (Na(+)/K(+)/Ca(2+)-exchange protein 3) (Solute carrier family 24 member 3)	SLC24A3 NCKX3	Homo sapiens (Human)	644	FUNCTION: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). {ECO:0000269|PubMed:11294880, ECO:0000269|PubMed:26631410}.		bone mineralization [GO:0030282]; calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transport [GO:0006811]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; potassium ion transmembrane transport [GO:0071805]; sodium ion transmembrane transport [GO:0035725]; transport across blood-brain barrier [GO:0150104]	cell periphery [GO:0071944]; plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]	cell periphery [GO:0071944]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]; bone mineralization [GO:0030282]; calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transport [GO:0006811]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; potassium ion transmembrane transport [GO:0071805]; sodium ion transmembrane transport [GO:0035725]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26631410}; Multi-pass membrane protein {ECO:0000255}.
Q9HC62	reviewed	SENP2_HUMAN	Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2)	SENP2 KIAA1331	Homo sapiens (Human)	589	FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11896061, PubMed:12192048, PubMed:20194620, PubMed:21965678, PubMed:15296745). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15296745). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:20194620, PubMed:21965678, PubMed:15296745). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity). {ECO:0000250|UniProtKB:Q91ZX6, ECO:0000269|PubMed:11896061, ECO:0000269|PubMed:12192048, ECO:0000269|PubMed:15296745, ECO:0000269|PubMed:20194620, ECO:0000269|PubMed:21965678}.		fat cell differentiation [GO:0045444]; mRNA transport [GO:0051028]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein ubiquitination [GO:0031398]; protein destabilization [GO:0031648]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of Wnt signaling pathway [GO:0030111]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	deSUMOylase activity [GO:0016929]; SUMO-specific endopeptidase activity [GO:0070139]	cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; deSUMOylase activity [GO:0016929]; SUMO-specific endopeptidase activity [GO:0070139]; fat cell differentiation [GO:0045444]; mRNA transport [GO:0051028]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein ubiquitination [GO:0031398]; protein destabilization [GO:0031648]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of Wnt signaling pathway [GO:0030111]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:12192048}. Nucleus membrane {ECO:0000269|PubMed:12192048}; Peripheral membrane protein {ECO:0000269|PubMed:12192048}; Nucleoplasmic side {ECO:0000269|PubMed:12192048}. Cytoplasm {ECO:0000269|PubMed:16738331}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000269|PubMed:16738331}.
Q9HC73	reviewed	CRLF2_HUMAN	Cytokine receptor-like factor 2 (Cytokine receptor-like 2) (IL-XR) (Thymic stromal lymphopoietin protein receptor) (TSLP receptor)	CRLF2 CRL2 ILXR TSLPR	Homo sapiens (Human)	371	FUNCTION: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. {ECO:0000250, ECO:0000269|PubMed:11418668}.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.	cytokine-mediated signaling pathway [GO:0019221]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of mast cell activation [GO:0033005]; positive regulation of receptor signaling pathway via STAT [GO:1904894]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; cytokine-mediated signaling pathway [GO:0019221]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of mast cell activation [GO:0033005]; positive regulation of receptor signaling pathway via STAT [GO:1904894]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q9HC77	reviewed	CENPJ_HUMAN	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1)	CENPJ CPAP LAP LIP1	Homo sapiens (Human)	1338	FUNCTION: Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}.		astral microtubule nucleation [GO:0030954]; cell division [GO:0051301]; centriole elongation [GO:0061511]; centriole replication [GO:0007099]; cilium assembly [GO:0060271]; microtubule nucleation [GO:0007020]; microtubule polymerization [GO:0046785]; motile cilium assembly [GO:0044458]; non-motile cilium assembly [GO:1905515]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centriole replication [GO:0046601]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of non-motile cilium assembly [GO:1902857]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of spindle assembly [GO:1905832]; regulation of centriole replication [GO:0046599]; regulation of mitotic spindle organization [GO:0060236]; smoothened signaling pathway [GO:0007224]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; gamma-tubulin small complex [GO:0008275]; microtubule [GO:0005874]; procentriole replication complex [GO:0120099]	gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; tubulin binding [GO:0015631]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; gamma-tubulin small complex [GO:0008275]; microtubule [GO:0005874]; procentriole replication complex [GO:0120099]; gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; tubulin binding [GO:0015631]; astral microtubule nucleation [GO:0030954]; cell division [GO:0051301]; centriole elongation [GO:0061511]; centriole replication [GO:0007099]; cilium assembly [GO:0060271]; microtubule nucleation [GO:0007020]; microtubule polymerization [GO:0046785]; motile cilium assembly [GO:0044458]; non-motile cilium assembly [GO:1905515]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centriole replication [GO:0046601]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of non-motile cilium assembly [GO:1902857]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of spindle assembly [GO:1905832]; regulation of centriole replication [GO:0046599]; regulation of mitotic spindle organization [GO:0060236]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11003675, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20531387}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124}. Note=Localized within the center of microtubule asters (PubMed:11003675). During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles (PubMed:17681131). {ECO:0000269|PubMed:11003675, ECO:0000269|PubMed:17681131}.
Q9HC78	reviewed	ZBT20_HUMAN	Zinc finger and BTB domain-containing protein 20 (Dendritic-derived BTB/POZ zinc finger protein) (Zinc finger protein 288)	ZBTB20 DPZF ZNF288	Homo sapiens (Human)	741	FUNCTION: May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). {ECO:0000250|UniProtKB:Q8K0L9, ECO:0000269|PubMed:11352661}.		cellular response to glucose stimulus [GO:0071333]; lipid homeostasis [GO:0055088]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cellular response to glucose stimulus [GO:0071333]; lipid homeostasis [GO:0055088]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8K0L9}.
Q9HC84	reviewed	MUC5B_HUMAN	Mucin-5B (MUC-5B) (Cervical mucin) (High molecular weight salivary mucin MG1) (Mucin-5 subtype B, tracheobronchial) (Sublingual gland mucin)	MUC5B MUC5	Homo sapiens (Human)	5762	FUNCTION: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.			extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Secreted.
Q9HC96	reviewed	CAN10_HUMAN	Calpain-10 (EC 3.4.22.-) (Calcium-activated neutral proteinase 10) (CANP 10)	CAPN10 KIAA1845	Homo sapiens (Human)	672	FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. {ECO:0000269|PubMed:17572128}.	MISCELLANEOUS: [Isoform B]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform D]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform E]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform F]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; cellular response to insulin stimulus [GO:0032869]; positive regulation of glucose import [GO:0046326]; positive regulation of insulin secretion [GO:0032024]; positive regulation of intracellular transport [GO:0032388]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; proteolysis [GO:0006508]; regulation of actin cytoskeleton organization [GO:0032956]; type B pancreatic cell apoptotic process [GO:0097050]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cytoskeletal protein binding [GO:0008092]; SNARE binding [GO:0000149]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cytoskeletal protein binding [GO:0008092]; SNARE binding [GO:0000149]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; cellular response to insulin stimulus [GO:0032869]; positive regulation of glucose import [GO:0046326]; positive regulation of insulin secretion [GO:0032024]; positive regulation of intracellular transport [GO:0032388]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; proteolysis [GO:0006508]; regulation of actin cytoskeleton organization [GO:0032956]; type B pancreatic cell apoptotic process [GO:0097050]	
Q9HC97	reviewed	GPR35_HUMAN	G-protein coupled receptor 35 (Kynurenic acid receptor) (KYNA receptor)	GPR35	Homo sapiens (Human)	309	FUNCTION: Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins. {ECO:0000269|PubMed:16754668}.		chemokine-mediated signaling pathway [GO:0070098]; cytoskeleton organization [GO:0007010]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of neuronal action potential [GO:1904456]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of Rho protein signal transduction [GO:0035025]	plasma membrane [GO:0005886]	C-X-C chemokine receptor activity [GO:0016494]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; C-X-C chemokine receptor activity [GO:0016494]; G protein-coupled receptor activity [GO:0004930]; chemokine-mediated signaling pathway [GO:0070098]; cytoskeleton organization [GO:0007010]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of neuronal action potential [GO:1904456]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of Rho protein signal transduction [GO:0035025]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16754668}; Multi-pass membrane protein {ECO:0000269|PubMed:16754668}. Note=Internalized to the cytoplasm after exposure to kynurenic acid.
Q9HC98	reviewed	NEK6_HUMAN	Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512)	NEK6	Homo sapiens (Human)	313	FUNCTION: Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:11516946, PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). {ECO:0000269|PubMed:11516946, ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361, ECO:0000269|PubMed:31409757}.		apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear membrane disassembly [GO:0007077]; mitotic spindle organization [GO:0007052]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; spindle assembly [GO:0051225]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; kinesin binding [GO:0019894]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; kinesin binding [GO:0019894]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear membrane disassembly [GO:0007077]; mitotic spindle organization [GO:0007052]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis.
Q9HCB6	reviewed	SPON1_HUMAN	Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor)	SPON1 KIAA0762 VSGP	Homo sapiens (Human)	807	FUNCTION: Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell. {ECO:0000250}.		cell adhesion [GO:0007155]; negative regulation of amyloid-beta formation [GO:1902430]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of protein processing [GO:0010954]; protein processing [GO:0016485]	endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	extracellular matrix structural constituent [GO:0005201]; LBD domain binding [GO:0050693]; metal ion binding [GO:0046872]	endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; LBD domain binding [GO:0050693]; metal ion binding [GO:0046872]; cell adhesion [GO:0007155]; negative regulation of amyloid-beta formation [GO:1902430]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of protein processing [GO:0010954]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q9HCC0	reviewed	MCCB_HUMAN	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)	MCCC2 MCCB	Homo sapiens (Human)	563	FUNCTION: Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195}.		branched-chain amino acid catabolic process [GO:0009083]; coenzyme A metabolic process [GO:0015936]; leucine catabolic process [GO:0006552]	3-methylcrotonyl-CoA carboxylase complex, mitochondrial [GO:0002169]; cytosol [GO:0005829]; methylcrotonoyl-CoA carboxylase complex [GO:1905202]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; methylcrotonoyl-CoA carboxylase activity [GO:0004485]	3-methylcrotonyl-CoA carboxylase complex, mitochondrial [GO:0002169]; cytosol [GO:0005829]; methylcrotonoyl-CoA carboxylase complex [GO:1905202]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; methylcrotonoyl-CoA carboxylase activity [GO:0004485]; branched-chain amino acid catabolic process [GO:0009083]; coenzyme A metabolic process [GO:0015936]; leucine catabolic process [GO:0006552]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:11170888, ECO:0000269|PubMed:16023992}.
Q9HCC8	reviewed	GDPD2_HUMAN	Glycerophosphoinositol inositolphosphodiesterase GDPD2 (EC 3.1.4.43) (Glycerophosphodiester phosphodiesterase 3) (Glycerophosphodiester phosphodiesterase domain-containing protein 2) (Osteoblast differentiation promoting factor)	GDPD2 GDE3 OBDPF UNQ1935/PRO4418	Homo sapiens (Human)	539	FUNCTION: Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4-phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; lipid metabolic process [GO:0006629]; positive regulation of osteoblast differentiation [GO:0045669]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]	glycerophosphodiester phosphodiesterase activity [GO:0008889]; glycerophosphoinositol inositolphosphodiesterase activity [GO:0047394]; metal ion binding [GO:0046872]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; glycerophosphoinositol inositolphosphodiesterase activity [GO:0047394]; metal ion binding [GO:0046872]; actin filament organization [GO:0007015]; lipid metabolic process [GO:0006629]; positive regulation of osteoblast differentiation [GO:0045669]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with the actin cytoskeleton. {ECO:0000250}.
Q9HCC9	reviewed	LST2_HUMAN	Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28)	ZFYVE28 KIAA1643 LST2	Homo sapiens (Human)	887	FUNCTION: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}.		negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]	metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19460345}. Early endosome membrane {ECO:0000269|PubMed:19460345}. Note=Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated.
Q9HCD5	reviewed	NCOA5_HUMAN	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA)	NCOA5 KIAA1637	Homo sapiens (Human)	579	FUNCTION: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}.		glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of signal transduction [GO:0009966]	actin cytoskeleton [GO:0015629]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]	actin cytoskeleton [GO:0015629]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Nucleus.
Q9HCD6	reviewed	TANC2_HUMAN	Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)	TANC2 KIAA1148 KIAA1636	Homo sapiens (Human)	1990	FUNCTION: Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}.		dense core granule cytoskeletal transport [GO:0099519]; regulation of dendritic spine development [GO:0060998]; regulation of dendritic spine morphogenesis [GO:0061001]	axon [GO:0030424]; dendritic spine [GO:0043197]		axon [GO:0030424]; dendritic spine [GO:0043197]; dense core granule cytoskeletal transport [GO:0099519]; regulation of dendritic spine development [GO:0060998]; regulation of dendritic spine morphogenesis [GO:0061001]	SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000269|PubMed:30021165}.
Q9HCE0	reviewed	EPG5_HUMAN	Ectopic P granules protein 5 homolog	EPG5 KIAA1632	Homo sapiens (Human)	2579	FUNCTION: Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located (PubMed:29130391). {ECO:0000269|PubMed:20550938, ECO:0000269|PubMed:23222957, ECO:0000269|PubMed:29130391}.		autophagosome maturation [GO:0097352]; cellular response to dsDNA [GO:1990786]; endocytic recycling [GO:0032456]; endosome to lysosome transport [GO:0008333]; nucleotide transport [GO:0006862]; toll-like receptor 9 signaling pathway [GO:0034162]	cytoplasm [GO:0005737]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]		cytoplasm [GO:0005737]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; autophagosome maturation [GO:0097352]; cellular response to dsDNA [GO:1990786]; endocytic recycling [GO:0032456]; endosome to lysosome transport [GO:0008333]; nucleotide transport [GO:0006862]; toll-like receptor 9 signaling pathway [GO:0034162]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:29130391}. Lysosome {ECO:0000269|PubMed:29130391}.
Q9HCE1	reviewed	MOV10_HUMAN	Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein)	MOV10 KIAA1631	Homo sapiens (Human)	1003	FUNCTION: 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:35157734, PubMed:27974568). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Inhibits also hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; defense response to virus [GO:0051607]; miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of neuron projection arborization [GO:0150011]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; retrotransposon silencing [GO:0010526]; retrotransposon silencing by mRNA destabilization [GO:0141008]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; P granule [GO:0043186]; P-body [GO:0000932]	5'-3' RNA helicase activity [GO:0032574]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; P granule [GO:0043186]; P-body [GO:0000932]; 5'-3' RNA helicase activity [GO:0032574]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; defense response to virus [GO:0051607]; miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of neuron projection arborization [GO:0150011]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; retrotransposon silencing [GO:0010526]; retrotransposon silencing by mRNA destabilization [GO:0141008]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30122351}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:30122351}. Cytoplasm, Stress granule {ECO:0000269|PubMed:23093941}. Nucleus {ECO:0000250|UniProtKB:P23249}. Cytoplasm {ECO:0000250|UniProtKB:P23249}. Note=Co-enriched in cytoplasmic foci with TUT4 (PubMed:30122351). In developing neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (By similarity). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30122351}.
Q9HCE5	reviewed	MET14_HUMAN	N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14) (hMETTL14)	METTL14 KIAA1627	Homo sapiens (Human)	456	FUNCTION: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:29348140, PubMed:27373337, PubMed:27281194). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q3UIK4, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:29348140}.		forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; mRNA methylation [GO:0080009]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; positive regulation of translation [GO:0045727]; regulation of neuron differentiation [GO:0045664]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	mRNA (N6-adenosine)-methyltransferase activity [GO:0001734]; mRNA binding [GO:0003729]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; mRNA (N6-adenosine)-methyltransferase activity [GO:0001734]; mRNA binding [GO:0003729]; forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; mRNA methylation [GO:0080009]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; positive regulation of translation [GO:0045727]; regulation of neuron differentiation [GO:0045664]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:29348140}.
Q9HCE6	reviewed	ARGAL_HUMAN	Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF)	ARHGEF10L GRINCHGEF KIAA1626	Homo sapiens (Human)	1279	FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. {ECO:0000269|PubMed:16112081}.		actin cytoskeleton organization [GO:0030036]; positive regulation of stress fiber assembly [GO:0051496]; regulation of small GTPase mediated signal transduction [GO:0051056]; SREBP signaling pathway [GO:0032933]	cytosol [GO:0005829]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; actin cytoskeleton organization [GO:0030036]; positive regulation of stress fiber assembly [GO:0051496]; regulation of small GTPase mediated signal transduction [GO:0051056]; SREBP signaling pathway [GO:0032933]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16112081}.
Q9HCE7	reviewed	SMUF1_HUMAN	E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)	SMURF1 KIAA1625	Homo sapiens (Human)	757	FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation (PubMed:21791611). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:10458166, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:21402695, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23999003}.		BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; ectoderm development [GO:0007398]; engulfment of target by autophagosome [GO:0061736]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite extension [GO:1903861]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein export from nucleus [GO:0006611]; protein localization to plasma membrane [GO:0072659]; protein polyubiquitination [GO:0000209]; protein targeting to vacuole involved in autophagy [GO:0071211]; protein ubiquitination [GO:0016567]; receptor catabolic process [GO:0032801]; substrate localization to autophagosome [GO:0061753]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	activin receptor binding [GO:0070697]; I-SMAD binding [GO:0070411]; phospholipid binding [GO:0005543]; R-SMAD binding [GO:0070412]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; activin receptor binding [GO:0070697]; I-SMAD binding [GO:0070411]; phospholipid binding [GO:0005543]; R-SMAD binding [GO:0070412]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; ectoderm development [GO:0007398]; engulfment of target by autophagosome [GO:0061736]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite extension [GO:1903861]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein export from nucleus [GO:0006611]; protein localization to plasma membrane [GO:0072659]; protein polyubiquitination [GO:0000209]; protein targeting to vacuole involved in autophagy [GO:0071211]; protein ubiquitination [GO:0016567]; receptor catabolic process [GO:0032801]; substrate localization to autophagosome [GO:0061753]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21572392}. Cell membrane {ECO:0000269|PubMed:21572392}; Peripheral membrane protein {ECO:0000269|PubMed:21572392}; Cytoplasmic side {ECO:0000269|PubMed:21572392}.
Q9HCE9	reviewed	ANO8_HUMAN	Anoctamin-8 (Transmembrane protein 16H)	ANO8 KIAA1623 TMEM16H	Homo sapiens (Human)	1232	FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC) activity.	MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.	chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]	endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]	endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Q9HCF6	reviewed	TRPM3_HUMAN	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2)	TRPM3 KIAA1616 LTRPC3	Homo sapiens (Human)	1732	FUNCTION: Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. In addition, forms heteromultimeric ion channels with TRPM1 which are permeable for calcium and zinc ions (PubMed:21278253). {ECO:0000269|PubMed:12672799, ECO:0000269|PubMed:12672827, ECO:0000269|PubMed:21278253}.		calcium ion transmembrane transport [GO:0070588]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; protein tetramerization [GO:0051262]	plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]; monoatomic cation channel activity [GO:0005261]	plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; monoatomic cation channel activity [GO:0005261]; calcium ion transmembrane transport [GO:0070588]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; protein tetramerization [GO:0051262]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12672827, ECO:0000305|PubMed:21278253}; Multi-pass membrane protein {ECO:0000269|PubMed:12672827}.
Q9HCG7	reviewed	GBA2_HUMAN	Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Bile acid beta-glucosidase GBA2) (Bile acid glucosyl transferase GBA2) (Cholesterol glucosyltransferase GBA2) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase GBA2) (EC 3.2.1.-) (Glucosylceramidase 2) (Non-lysosomal cholesterol glycosyltransferase) (Non-lysosomal galactosylceramidase) (EC 3.2.1.46) (Non-lysosomal glycosylceramidase)	GBA2 KIAA1605 SPG46 AD035	Homo sapiens (Human)	927	FUNCTION: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) to free glucose and ceramides (such as N-acylsphing-4-enine) (PubMed:17105727, PubMed:30308956, PubMed:32144204). GlcCers are membrane glycosphingolipids that have a wide intracellular distribution (By similarity). They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (By similarity). Involved in the transglucosylation of cholesterol, transfers glucose from GlcCer to cholesterol, thereby modifying its water solubility and biological properties (PubMed:32144204). Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-3-beta-D-glucoside to ceramide (such as N-acylsphing-4-enine) (Probable). May play a role in the metabolism of bile acids (PubMed:11489889, PubMed:9111029, PubMed:17080196). Able to hydrolyze bile acid 3-O-glucosides as well as to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity (PubMed:11489889, PubMed:9111029, PubMed:17080196). Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the galactosyl transfer between GalCers and cholesterol in vitro with lower activity compared with their activity against GlcCers (PubMed:32144204). {ECO:0000250|UniProtKB:Q69ZF3, ECO:0000269|PubMed:11489889, ECO:0000269|PubMed:17080196, ECO:0000269|PubMed:17105727, ECO:0000269|PubMed:30308956, ECO:0000269|PubMed:32144204, ECO:0000269|PubMed:9111029, ECO:0000305|PubMed:32144204}.		bile acid metabolic process [GO:0008206]; carbohydrate metabolic process [GO:0005975]; central nervous system development [GO:0007417]; central nervous system neuron development [GO:0021954]; cholesterol metabolic process [GO:0008203]; glucosylceramide catabolic process [GO:0006680]; glycoside catabolic process [GO:0016139]; glycosphingolipid metabolic process [GO:0006687]; lipid glycosylation [GO:0030259]; regulation of actin filament polymerization [GO:0030833]; regulation of membrane lipid distribution [GO:0097035]; regulation of microtubule polymerization [GO:0031113]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]	beta-glucosidase activity [GO:0008422]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glucosyltransferase activity [GO:0046527]; steryl-beta-glucosidase activity [GO:0050295]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; beta-glucosidase activity [GO:0008422]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glucosyltransferase activity [GO:0046527]; steryl-beta-glucosidase activity [GO:0050295]; bile acid metabolic process [GO:0008206]; carbohydrate metabolic process [GO:0005975]; central nervous system development [GO:0007417]; central nervous system neuron development [GO:0021954]; cholesterol metabolic process [GO:0008203]; glucosylceramide catabolic process [GO:0006680]; glycoside catabolic process [GO:0016139]; glycosphingolipid metabolic process [GO:0006687]; lipid glycosylation [GO:0030259]; regulation of actin filament polymerization [GO:0030833]; regulation of membrane lipid distribution [GO:0097035]; regulation of microtubule polymerization [GO:0031113]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q69ZF3}; Peripheral membrane protein {ECO:0000269|PubMed:11489889}; Cytoplasmic side {ECO:0000250|UniProtKB:Q69ZF3}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q69ZF3}; Peripheral membrane protein {ECO:0000269|PubMed:11489889}; Cytoplasmic side {ECO:0000250|UniProtKB:Q69ZF3}. Note=Localization to the plasma membrane and alternative topologies have also been reported. {ECO:0000269|PubMed:11489889, ECO:0000269|PubMed:17105727}.
Q9HCG8	reviewed	CWC22_HUMAN	Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb)	CWC22 KIAA1604 NCM	Homo sapiens (Human)	908	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:12226669, PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12226669, ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}.		mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106}. Nucleus speckle {ECO:0000269|PubMed:22961380}. Note=Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins. {ECO:0000269|PubMed:22961380}.
Q9HCH0	reviewed	NCK5L_HUMAN	Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169)	NCKAP5L CEP169 KIAA1602 FP1193	Homo sapiens (Human)	1334	FUNCTION: Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573). {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573}.	MISCELLANEOUS: [Isoform 2]: Dubious isoform produced through intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Dubious isoform produced through intron retention. {ECO:0000305}.	microtubule bundle formation [GO:0001578]; microtubule depolymerization [GO:0007019]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule plus-end [GO:0035371]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule plus-end [GO:0035371]; microtubule bundle formation [GO:0001578]; microtubule depolymerization [GO:0007019]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:26549230}. Note=Localizes to microtubule plus ends (PubMed:26485573, PubMed:26482847). Associates with centrosomes during interphase, but dissociates from these structures from the onset of mitosis (PubMed:26549230). {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:26549230}.
Q9HCH3	reviewed	CPNE5_HUMAN	Copine-5 (Copine V)	CPNE5 KIAA1599	Homo sapiens (Human)	593	FUNCTION: Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99829, ECO:0000269|PubMed:23999003}.		cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]	extracellular exosome [GO:0070062]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]	calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]	SUBCELLULAR LOCATION: Perikaryon {ECO:0000250|UniProtKB:Q8JZW4}. Cell projection {ECO:0000250|UniProtKB:Q8JZW4}.
Q9HCH5	reviewed	SYTL2_HUMAN	Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4)	SYTL2 KIAA1597 SGA72M SLP2 SLP2A	Homo sapiens (Human)	934	FUNCTION: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}.		exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; exocytic vesicle [GO:0070382]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]	neurexin family protein binding [GO:0042043]; phosphatase binding [GO:0019902]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; exocytic vesicle [GO:0070382]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; neurexin family protein binding [GO:0042043]; phosphatase binding [GO:0019902]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; small GTPase binding [GO:0031267]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:18812475}. Cell membrane {ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A. {ECO:0000269|PubMed:18812475}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:17182843}. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. {ECO:0000269|PubMed:17182843}.
Q9HCI5	reviewed	MAGE1_HUMAN	Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (Hepatocellular carcinoma-associated protein 1) (MAGE-E1 antigen)	MAGEE1 HCA1 KIAA1587	Homo sapiens (Human)	957	FUNCTION: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	dendrite [GO:0030425]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]		dendrite [GO:0030425]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane (By similarity). {ECO:0000250}.
Q9HCI7	reviewed	MSL2_HUMAN	E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.-) (E3 ubiquitin-protein transferase MSL2) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184)	MSL2 KIAA1585 MSL2L1 RNF184	Homo sapiens (Human)	577	FUNCTION: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. {ECO:0000269|PubMed:21726816}.		positive regulation of DNA-templated transcription [GO:0045893]; protein ubiquitination [GO:0016567]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	MSL complex [GO:0072487]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	MSL complex [GO:0072487]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of DNA-templated transcription [GO:0045893]; protein ubiquitination [GO:0016567]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	
Q9HCJ0	reviewed	TNR6C_HUMAN	Trinucleotide repeat-containing gene 6C protein	TNRC6C KIAA1582	Homo sapiens (Human)	1690	FUNCTION: Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:21984184, ECO:0000269|PubMed:21984185}.		miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]	RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RNA binding [GO:0003723]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]	
Q9HCJ1	reviewed	ANKH_HUMAN	Mineralization regulator ANKH (ATP carrier protein ANKH) (Progressive ankylosis protein homolog) (ANK)	ANKH KIAA1581 UNQ241/PRO274	Homo sapiens (Human)	492	FUNCTION: Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1 (PubMed:32639996, PubMed:35147247, PubMed:20943778). Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength (PubMed:32639996). The transport mechanism remains to be elucidated (Probable). {ECO:0000269|PubMed:20943778, ECO:0000269|PubMed:32639996, ECO:0000269|PubMed:35147247, ECO:0000305|PubMed:32639996, ECO:0000305|PubMed:35147247}.		ATP export [GO:1904669]; bone mineralization [GO:0030282]; calcium ion homeostasis [GO:0055074]; cementum mineralization [GO:0071529]; diphosphate metabolic process [GO:0071344]; gene expression [GO:0010467]; inhibition of non-skeletal tissue mineralization [GO:0140928]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; phosphate ion homeostasis [GO:0055062]; regulation of bone mineralization [GO:0030500]; response to sodium phosphate [GO:1904383]; skeletal system development [GO:0001501]; transmembrane transport [GO:0055085]	extracellular region [GO:0005576]; membrane [GO:0016020]; outer membrane [GO:0019867]; plasma membrane [GO:0005886]	ATP transmembrane transporter activity [GO:0005347]; inorganic diphosphate transmembrane transporter activity [GO:0030504]; inorganic phosphate transmembrane transporter activity [GO:0005315]; phosphate ion transmembrane transporter activity [GO:0015114]	extracellular region [GO:0005576]; membrane [GO:0016020]; outer membrane [GO:0019867]; plasma membrane [GO:0005886]; ATP transmembrane transporter activity [GO:0005347]; inorganic diphosphate transmembrane transporter activity [GO:0030504]; inorganic phosphate transmembrane transporter activity [GO:0005315]; phosphate ion transmembrane transporter activity [GO:0015114]; ATP export [GO:1904669]; bone mineralization [GO:0030282]; calcium ion homeostasis [GO:0055074]; cementum mineralization [GO:0071529]; diphosphate metabolic process [GO:0071344]; gene expression [GO:0010467]; inhibition of non-skeletal tissue mineralization [GO:0140928]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; phosphate ion homeostasis [GO:0055062]; regulation of bone mineralization [GO:0030500]; response to sodium phosphate [GO:1904383]; skeletal system development [GO:0001501]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20943778}; Multi-pass membrane protein {ECO:0000255}.
Q9HCJ2	reviewed	LRC4C_HUMAN	Leucine-rich repeat-containing protein 4C (Netrin-G1 ligand) (NGL-1)	LRRC4C KIAA1580 NGL1 UNQ292/PRO331	Homo sapiens (Human)	640	FUNCTION: May promote neurite outgrowth of developing thalamic neurons. {ECO:0000269|PubMed:14595443}.		modulation of chemical synaptic transmission [GO:0050804]; regulation of axonogenesis [GO:0050770]; synaptic membrane adhesion [GO:0099560]	extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]	cell adhesion molecule binding [GO:0050839]; cell-cell adhesion mediator activity [GO:0098632]	extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; cell adhesion molecule binding [GO:0050839]; cell-cell adhesion mediator activity [GO:0098632]; modulation of chemical synaptic transmission [GO:0050804]; regulation of axonogenesis [GO:0050770]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}; Single-pass type I membrane protein {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}.
Q9HCK0	reviewed	ZBT26_HUMAN	Zinc finger and BTB domain-containing protein 26 (Zinc finger protein 481) (Zinc finger protein Bioref)	ZBTB26 KIAA1572 ZNF481	Homo sapiens (Human)	441	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	nucleoplasm [GO:0005654]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleoplasm [GO:0005654]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9HCK4	reviewed	ROBO2_HUMAN	Roundabout homolog 2	ROBO2 KIAA1568	Homo sapiens (Human)	1378	FUNCTION: Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.		aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; cellular response to hormone stimulus [GO:0032870]; central nervous system development [GO:0007417]; endocardial cushion formation [GO:0003272]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; metanephros development [GO:0001656]; negative regulation of negative chemotaxis [GO:0050925]; negative regulation of synapse assembly [GO:0051964]; olfactory bulb interneuron development [GO:0021891]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of Notch signaling pathway involved in heart induction [GO:0035481]; pulmonary valve morphogenesis [GO:0003184]; retinal ganglion cell axon guidance [GO:0031290]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412]	axolemma [GO:0030673]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]	axolemma [GO:0030673]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]; aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; cellular response to hormone stimulus [GO:0032870]; central nervous system development [GO:0007417]; endocardial cushion formation [GO:0003272]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; metanephros development [GO:0001656]; negative regulation of negative chemotaxis [GO:0050925]; negative regulation of synapse assembly [GO:0051964]; olfactory bulb interneuron development [GO:0021891]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of Notch signaling pathway involved in heart induction [GO:0035481]; pulmonary valve morphogenesis [GO:0003184]; retinal ganglion cell axon guidance [GO:0031290]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9HCK5	reviewed	AGO4_HUMAN	Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4)	AGO4 EIF2C4 KIAA1567	Homo sapiens (Human)	861	FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). {ECO:0000255|HAMAP-Rule:MF_03033, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:18552826, ECO:0000269|PubMed:18771919}.		male gonad development [GO:0008584]; male meiotic nuclear division [GO:0007140]; miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA catabolic process [GO:0006402]; negative regulation of apoptotic process [GO:0043066]; pre-miRNA processing [GO:0031054]; regulation of cell morphogenesis [GO:0022604]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]; synaptonemal complex assembly [GO:0007130]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]	double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]; male gonad development [GO:0008584]; male meiotic nuclear division [GO:0007140]; miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA catabolic process [GO:0006402]; negative regulation of apoptotic process [GO:0043066]; pre-miRNA processing [GO:0031054]; regulation of cell morphogenesis [GO:0022604]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03033, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:19167051}.
Q9HCK8	reviewed	CHD8_HUMAN	Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)	CHD8 HELSNF1 KIAA1564	Homo sapiens (Human)	2581	FUNCTION: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:36537238}.	MISCELLANEOUS: Its gene is located in the 14q11.2 region of the genome which is associated with developmental delay, cognitive impairment and similar minor anomalies in some children, suggesting that it may be a good candidate for the phenotype.	brain development [GO:0007420]; chromatin remodeling [GO:0006338]; digestive tract development [GO:0048565]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prepulse inhibition [GO:0060134]; social behavior [GO:0035176]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039]	chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039]; brain development [GO:0007420]; chromatin remodeling [GO:0006338]; digestive tract development [GO:0048565]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prepulse inhibition [GO:0060134]; social behavior [GO:0035176]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:20453063, ECO:0000269|PubMed:36537238}. Note=Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites. {ECO:0000255|HAMAP-Rule:MF_03071}.
Q9HCL2	reviewed	GPAT1_HUMAN	Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15)	GPAM GPAT1 KIAA1560	Homo sapiens (Human)	828	FUNCTION: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids. {ECO:0000269|PubMed:18238778}.		activated T cell proliferation [GO:0050798]; activation-induced cell death of T cells [GO:0006924]; acyl-CoA metabolic process [GO:0006637]; CDP-diacylglycerol biosynthetic process [GO:0016024]; defense response to virus [GO:0051607]; diacylglycerol biosynthetic process [GO:0006651]; fatty acid homeostasis [GO:0055089]; fatty acid metabolic process [GO:0006631]; glycerol-3-phosphate metabolic process [GO:0006072]; negative regulation of activation-induced cell death of T cells [GO:0070236]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylglycerol biosynthetic process [GO:0006655]; phospholipid biosynthetic process [GO:0008654]; phospholipid homeostasis [GO:0055091]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of multicellular organism growth [GO:0040018]; regulation of cytokine production [GO:0001817]; response to glucose [GO:0009749]; triglyceride biosynthetic process [GO:0019432]	mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]	glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420]	mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420]; activated T cell proliferation [GO:0050798]; activation-induced cell death of T cells [GO:0006924]; acyl-CoA metabolic process [GO:0006637]; CDP-diacylglycerol biosynthetic process [GO:0016024]; defense response to virus [GO:0051607]; diacylglycerol biosynthetic process [GO:0006651]; fatty acid homeostasis [GO:0055089]; fatty acid metabolic process [GO:0006631]; glycerol-3-phosphate metabolic process [GO:0006072]; negative regulation of activation-induced cell death of T cells [GO:0070236]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylglycerol biosynthetic process [GO:0006655]; phospholipid biosynthetic process [GO:0008654]; phospholipid homeostasis [GO:0055091]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of multicellular organism growth [GO:0040018]; regulation of cytokine production [GO:0001817]; response to glucose [GO:0009749]; triglyceride biosynthetic process [GO:0019432]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P97564}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97564}.
Q9HCM1	reviewed	RESF1_HUMAN	Retroelement silencing factor 1	RESF1 C12orf35 KIAA1551	Homo sapiens (Human)	1747	FUNCTION: Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}.		negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]	nucleus [GO:0005634]	histone binding [GO:0042393]; histone methyltransferase binding [GO:1990226]	nucleus [GO:0005634]; histone binding [GO:0042393]; histone methyltransferase binding [GO:1990226]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5DTW7}. Note=Localizes around gamma-tubulin during M phase. {ECO:0000250|UniProtKB:Q5DTW7}.
Q9HCM2	reviewed	PLXA4_HUMAN	Plexin-A4	PLXNA4 KIAA1550 PLXNA4A PLXNA4B UNQ2820/PRO34003	Homo sapiens (Human)	1894	FUNCTION: Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.		anterior commissure morphogenesis [GO:0021960]; chemorepulsion of branchiomotor axon [GO:0021793]; embryonic heart tube development [GO:0035050]; facial nerve structural organization [GO:0021612]; glossopharyngeal nerve morphogenesis [GO:0021615]; maintenance of synapse structure [GO:0099558]; negative regulation of cell adhesion [GO:0007162]; positive regulation of axonogenesis [GO:0050772]; postganglionic parasympathetic fiber development [GO:0021784]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of negative chemotaxis [GO:0050923]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; sympathetic nervous system development [GO:0048485]; sympathetic neuron axon guidance [GO:0097492]; trigeminal nerve structural organization [GO:0021637]; vagus nerve morphogenesis [GO:0021644]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	semaphorin receptor activity [GO:0017154]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]; semaphorin receptor activity [GO:0017154]; anterior commissure morphogenesis [GO:0021960]; chemorepulsion of branchiomotor axon [GO:0021793]; embryonic heart tube development [GO:0035050]; facial nerve structural organization [GO:0021612]; glossopharyngeal nerve morphogenesis [GO:0021615]; maintenance of synapse structure [GO:0099558]; negative regulation of cell adhesion [GO:0007162]; positive regulation of axonogenesis [GO:0050772]; postganglionic parasympathetic fiber development [GO:0021784]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of negative chemotaxis [GO:0050923]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; sympathetic nervous system development [GO:0048485]; sympathetic neuron axon guidance [GO:0097492]; trigeminal nerve structural organization [GO:0021637]; vagus nerve morphogenesis [GO:0021644]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9HCM3	reviewed	K1549_HUMAN	UPF0606 protein KIAA1549	KIAA1549	Homo sapiens (Human)	1950	FUNCTION: May play a role in photoreceptor function. {ECO:0000269|PubMed:30120214}.	MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative promoter usage. {ECO:0000305}.		photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886]		photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:Q68FD9}. Note=In the retinal photoreceptor cells, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment. {ECO:0000250|UniProtKB:Q68FD9}.
Q9HCM4	reviewed	E41L5_HUMAN	Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5)	EPB41L5 KIAA1548	Homo sapiens (Human)	733	FUNCTION: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}.		actomyosin structure organization [GO:0031032]; apical constriction [GO:0003383]; axial mesoderm morphogenesis [GO:0048319]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ectoderm development [GO:0007398]; embryonic foregut morphogenesis [GO:0048617]; endoderm development [GO:0007492]; epithelial to mesenchymal transition [GO:0001837]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mesoderm migration involved in gastrulation [GO:0007509]; negative regulation of cell-cell adhesion [GO:0022408]; neural plate morphogenesis [GO:0001839]; paraxial mesoderm development [GO:0048339]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of focal adhesion assembly [GO:0051894]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of establishment of protein localization [GO:0070201]; somite rostral/caudal axis specification [GO:0032525]; substrate-dependent cell migration, cell attachment to substrate [GO:0006931]; unidimensional cell growth [GO:0009826]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	cytoskeletal protein binding [GO:0008092]; protein domain specific binding [GO:0019904]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; cytoskeletal protein binding [GO:0008092]; protein domain specific binding [GO:0019904]; actomyosin structure organization [GO:0031032]; apical constriction [GO:0003383]; axial mesoderm morphogenesis [GO:0048319]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ectoderm development [GO:0007398]; embryonic foregut morphogenesis [GO:0048617]; endoderm development [GO:0007492]; epithelial to mesenchymal transition [GO:0001837]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mesoderm migration involved in gastrulation [GO:0007509]; negative regulation of cell-cell adhesion [GO:0022408]; neural plate morphogenesis [GO:0001839]; paraxial mesoderm development [GO:0048339]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of focal adhesion assembly [GO:0051894]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of establishment of protein localization [GO:0070201]; somite rostral/caudal axis specification [GO:0032525]; substrate-dependent cell migration, cell attachment to substrate [GO:0006931]; unidimensional cell growth [GO:0009826]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BGS1}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q8BGS1}. Cell membrane {ECO:0000250|UniProtKB:Q8BGS1}; Peripheral membrane protein {ECO:0000305}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q5FVG2}.
Q9HCM9	reviewed	TRI39_HUMAN	E3 ubiquitin-protein ligase TRIM39 (EC 2.3.2.27) (RING finger protein 23) (RING-type E3 ubiquitin transferase TRIM39) (Testis-abundant finger protein) (Tripartite motif-containing protein 39)	TRIM39 RNF23 TFP	Homo sapiens (Human)	518	FUNCTION: [Isoform 1]: E3 ubiquitin-protein ligase (PubMed:22529100). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251). {ECO:0000269|PubMed:19100260, ECO:0000269|PubMed:22529100, ECO:0000269|PubMed:23213251}.; FUNCTION: [Isoform 2]: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251). Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner (PubMed:26363554). {ECO:0000269|PubMed:23213251, ECO:0000269|PubMed:26363554}.		apoptotic process [GO:0006915]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of cell cycle G1/S phase transition [GO:1902806]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of cell cycle G1/S phase transition [GO:1902806]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:19100260}. Mitochondrion {ECO:0000269|PubMed:19100260}. Nucleus {ECO:0000269|PubMed:23213251}. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. {ECO:0000269|PubMed:19100260, ECO:0000269|PubMed:23213251}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:23213251}. Note=Colocalizes with CDKN1A in the nucleus. {ECO:0000269|PubMed:23213251}.
Q9HCN3	reviewed	PGAP6_HUMAN	Post-GPI attachment to proteins factor 6 (EC 3.1.1.4) (GPI processing phospholipase A2) (GPI-PLA2) (Protein M83) (Transmembrane protein 6) (Transmembrane protein 8) (Transmembrane protein 8A)	PGAP6 TMEM6 TMEM8 TMEM8A	Homo sapiens (Human)	771	FUNCTION: Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401). {ECO:0000269|PubMed:26858401, ECO:0000269|PubMed:27835684, ECO:0000269|PubMed:27881714}.		lipid metabolic process [GO:0006629]	extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	phospholipase A2 activity [GO:0004623]	extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; phospholipase A2 activity [GO:0004623]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27881714}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:21752829}; Multi-pass membrane protein {ECO:0000255}.
Q9HCN4	reviewed	GPN1_HUMAN	GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1)	GPN1 MBDIN RPAP4 XAB1 HUSSY-23	Homo sapiens (Human)	374	FUNCTION: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:20855544, ECO:0000269|PubMed:21768307, ECO:0000305|PubMed:11058119}.			cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11058119, ECO:0000269|PubMed:20855544}. Nucleus {ECO:0000269|PubMed:20855544}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:20855544}.
Q9HCN6	reviewed	GPVI_HUMAN	Platelet glycoprotein VI (GPVI) (Glycoprotein 6)	GP6	Homo sapiens (Human)	339	FUNCTION: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. {ECO:0000269|PubMed:10961879, ECO:0000269|PubMed:18955485}.	MISCELLANEOUS: [Isoform 3]: Has no transmembrane domain. Does not interact with Fc receptor gamma chain. Does not bind to collagen-like peptides. {ECO:0000305}.	collagen-activated signaling pathway [GO:0038065]; enzyme-linked receptor protein signaling pathway [GO:0007167]; platelet activation [GO:0030168]; positive regulation of platelet aggregation [GO:1901731]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197]	collagen binding [GO:0005518]; protein tyrosine kinase binding [GO:1990782]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197]; collagen binding [GO:0005518]; protein tyrosine kinase binding [GO:1990782]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; collagen-activated signaling pathway [GO:0038065]; enzyme-linked receptor protein signaling pathway [GO:0007167]; platelet activation [GO:0030168]; positive regulation of platelet aggregation [GO:1901731]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass membrane protein.
Q9HCP0	reviewed	KC1G1_HUMAN	Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1)	CSNK1G1	Homo sapiens (Human)	422	FUNCTION: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN. {ECO:0000250, ECO:0000269|PubMed:21680713}.	MISCELLANEOUS: [Isoform 1S]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	endocytosis [GO:0006897]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; endocytosis [GO:0006897]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm.
Q9HCP6	reviewed	HHATL_HUMAN	Protein-cysteine N-palmitoyltransferase HHAT-like protein (Glycerol uptake/transporter homolog) (Hedgehog acyltransferase-like protein)	HHATL C3orf3 GUP1 KIAA1173	Homo sapiens (Human)	504	FUNCTION: Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN. {ECO:0000250}.		negative regulation of N-terminal protein palmitoylation [GO:0060262]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]	acyltransferase activity [GO:0016746]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; acyltransferase activity [GO:0016746]; negative regulation of N-terminal protein palmitoylation [GO:0060262]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9HCQ5	reviewed	GALT9_HUMAN	Polypeptide N-acetylgalactosaminyltransferase 9 (EC 2.4.1.41) (Polypeptide GalNAc transferase 9) (GalNAc-T9) (pp-GaNTase 9) (Protein-UDP acetylgalactosaminyltransferase 9) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9)	GALNT9	Homo sapiens (Human)	603	FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3. {ECO:0000269|PubMed:10978536, ECO:0000269|PubMed:12407114}.		O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9HCQ7	reviewed	NPVF_HUMAN	Pro-FMRFamide-related neuropeptide VF [Cleaved into: Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide RFRP-2; Neuropeptide NPVF (Neuropeptide RFRP-3)]	NPVF C7orf9 RFRP	Homo sapiens (Human)	196	FUNCTION: Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine-induced analgesia. {ECO:0000269|PubMed:11025660, ECO:0000269|PubMed:20027225}.		negative regulation of gonadotropin secretion [GO:0032277]; neuropeptide signaling pathway [GO:0007218]	extracellular region [GO:0005576]	signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; signaling receptor binding [GO:0005102]; negative regulation of gonadotropin secretion [GO:0032277]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Secreted.
Q9HCR9	reviewed	PDE11_HUMAN	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A)	PDE11A	Homo sapiens (Human)	933	FUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148). {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:10906126, ECO:0000269|PubMed:11050148, ECO:0000269|PubMed:16330539}.		metabolic process [GO:0008152]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754]; signal transduction [GO:0007165]	cytosol [GO:0005829]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP binding [GO:0030553]; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; cyclic-nucleotide phosphodiesterase activity [GO:0004112]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP binding [GO:0030553]; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; cyclic-nucleotide phosphodiesterase activity [GO:0004112]; metal ion binding [GO:0046872]; metabolic process [GO:0008152]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10906126}.
Q9HCS2	reviewed	CP4FC_HUMAN	Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12)	CYP4F12 UNQ568/PRO1129	Homo sapiens (Human)	524	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-2 position. Metabolizes (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) toward 18-hydroxy arachidonate (PubMed:11162607). Catalyzes the epoxidation of double bonds of PUFAs such as docosapentaenoic and docosahexaenoic acids (PubMed:16112640). Has low omega-hydroxylase activity toward leukotriene B4 and arachidonate (PubMed:11162645). Involved in the metabolism of xenobiotics. Catalyzes the hydroxylation of the antihistamine drug ebastine (PubMed:11162645). {ECO:0000269|PubMed:11162607, ECO:0000269|PubMed:11162645, ECO:0000269|PubMed:16112640}.		arachidonic acid metabolic process [GO:0019369]; epoxygenase P450 pathway [GO:0019373]; fatty acid metabolic process [GO:0006631]; leukotriene B4 catabolic process [GO:0036101]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; phylloquinone catabolic process [GO:0042376]; pressure natriuresis [GO:0003095]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; xenobiotic metabolic process [GO:0006805]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	alkane 1-monooxygenase activity [GO:0018685]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; monooxygenase activity [GO:0004497]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; alkane 1-monooxygenase activity [GO:0018685]; arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; monooxygenase activity [GO:0004497]; arachidonic acid metabolic process [GO:0019369]; epoxygenase P450 pathway [GO:0019373]; fatty acid metabolic process [GO:0006631]; leukotriene B4 catabolic process [GO:0036101]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; phylloquinone catabolic process [GO:0042376]; pressure natriuresis [GO:0003095]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9HBI6}. Microsome membrane {ECO:0000250|UniProtKB:Q9HBI6}.
Q9HCS4	reviewed	TF7L1_HUMAN	Transcription factor 7-like 1 (HMG box transcription factor 3) (TCF-3)	TCF7L1 TCF3	Homo sapiens (Human)	588	FUNCTION: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. {ECO:0000250}.		canonical Wnt signaling pathway [GO:0060070]; chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]	beta-catenin-TCF complex [GO:1990907]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	beta-catenin-TCF complex [GO:1990907]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; canonical Wnt signaling pathway [GO:0060070]; chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]	SUBCELLULAR LOCATION: Nucleus.
Q9HCS7	reviewed	SYF1_HUMAN	Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2)	XAB2 HCNP KIAA1177 SYF1 PP3898	Homo sapiens (Human)	855	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804). {ECO:0000269|PubMed:10944529, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:17981804, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.		blastocyst development [GO:0001824]; DNA-templated transcription [GO:0006351]; generation of catalytic spliceosome for first transesterification step [GO:0000349]; mRNA splicing, via spliceosome [GO:0000398]; transcription-coupled nucleotide-excision repair [GO:0006283]	catalytic step 2 spliceosome [GO:0071013]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007]		catalytic step 2 spliceosome [GO:0071013]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007]; blastocyst development [GO:0001824]; DNA-templated transcription [GO:0006351]; generation of catalytic spliceosome for first transesterification step [GO:0000349]; mRNA splicing, via spliceosome [GO:0000398]; transcription-coupled nucleotide-excision repair [GO:0006283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. Note=Detected in the splicing complex carrying pre-mRNA. {ECO:0000250|UniProtKB:Q99PK0}.
Q9HCU0	reviewed	CD248_HUMAN	Endosialin (Tumor endothelial marker 1) (CD antigen CD248)	CD248 CD164L1 TEM1	Homo sapiens (Human)	757	FUNCTION: May play a role in tumor angiogenesis. {ECO:0000269|PubMed:15862292}.		anatomical structure regression [GO:0060033]; cell migration [GO:0016477]; endothelial cell apoptotic process [GO:0072577]; fibroblast migration [GO:0010761]; fibroblast proliferation [GO:0048144]; lymph node development [GO:0048535]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fibroblast proliferation [GO:0048146]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; extracellular matrix binding [GO:0050840]; extracellular matrix protein binding [GO:1990430]	cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; extracellular matrix binding [GO:0050840]; extracellular matrix protein binding [GO:1990430]; anatomical structure regression [GO:0060033]; cell migration [GO:0016477]; endothelial cell apoptotic process [GO:0072577]; fibroblast migration [GO:0010761]; fibroblast proliferation [GO:0048144]; lymph node development [GO:0048535]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fibroblast proliferation [GO:0048146]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9HCU4	reviewed	CELR2_HUMAN	Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3)	CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3	Homo sapiens (Human)	2923	FUNCTION: Receptor that may have an important role in cell/cell signaling during nervous system formation.		cell-cell adhesion [GO:0098609]; cerebrospinal fluid secretion [GO:0033326]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; dendrite morphogenesis [GO:0048813]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; motor neuron migration [GO:0097475]; neural plate anterior/posterior regionalization [GO:0021999]; regulation of cell-cell adhesion [GO:0022407]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; ventricular system development [GO:0021591]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; cell-cell adhesion [GO:0098609]; cerebrospinal fluid secretion [GO:0033326]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; dendrite morphogenesis [GO:0048813]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; motor neuron migration [GO:0097475]; neural plate anterior/posterior regionalization [GO:0021999]; regulation of cell-cell adhesion [GO:0022407]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; ventricular system development [GO:0021591]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9HCU5	reviewed	PREB_HUMAN	Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12)	PREB SEC12	Homo sapiens (Human)	417	FUNCTION: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. {ECO:0000250|UniProtKB:Q9WTV0, ECO:0000250|UniProtKB:Q9WUQ2}.; FUNCTION: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. {ECO:0000250|UniProtKB:Q9WTV0}.		COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein exit from endoplasmic reticulum [GO:0032527]; protein secretion [GO:0009306]; regulation of COPII vesicle coating [GO:0003400]	endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]	DNA binding [GO:0003677]; GTPase activator activity [GO:0005096]; GTPase binding [GO:0051020]; guanyl-nucleotide exchange factor activity [GO:0005085]	endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; DNA binding [GO:0003677]; GTPase activator activity [GO:0005096]; GTPase binding [GO:0051020]; guanyl-nucleotide exchange factor activity [GO:0005085]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein exit from endoplasmic reticulum [GO:0032527]; protein secretion [GO:0009306]; regulation of COPII vesicle coating [GO:0003400]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9WTV0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WTV0}. Nucleus {ECO:0000250|UniProtKB:Q9WTV0}. Note=Concentrates at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). {ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:28442536}.
Q9HCU8	reviewed	DPOD4_HUMAN	DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12)	POLD4 POLDS	Homo sapiens (Human)	107	FUNCTION: As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity (PubMed:16510448, PubMed:19074196, PubMed:20334433). Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system (PubMed:24035200). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb (PubMed:24310611). Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196). Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival (PubMed:24022480). {ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24022480, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611}.		DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; positive regulation of endothelial cell proliferation [GO:0001938]	delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654]		delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; positive regulation of endothelial cell proliferation [GO:0001938]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22801543}. Note=Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation. {ECO:0000269|PubMed:22801543}.
Q9HCU9	reviewed	BRMS1_HUMAN	Breast cancer metastasis-suppressor 1	BRMS1	Homo sapiens (Human)	246	FUNCTION: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. {ECO:0000269|PubMed:14581478, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:20830743}.		apoptotic process [GO:0006915]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of anoikis [GO:2000210]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of apoptotic process [GO:0042981]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; Sin3-type complex [GO:0070822]	histone deacetylase binding [GO:0042826]; NF-kappaB binding [GO:0051059]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; Sin3-type complex [GO:0070822]; histone deacetylase binding [GO:0042826]; NF-kappaB binding [GO:0051059]; apoptotic process [GO:0006915]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of anoikis [GO:2000210]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear.
Q9HCX3	reviewed	ZN304_HUMAN	Zinc finger protein 304 (KRAB-containing zinc finger protein)	ZNF304	Homo sapiens (Human)	659	FUNCTION: Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979). Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979). Promotes angiogenesis (PubMed:26081979). Promotes tumor growth (PubMed:24623306, PubMed:26081979). {ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:26081979}.		angiogenesis [GO:0001525]; chromatin organization [GO:0006325]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of anoikis [GO:2000811]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; angiogenesis [GO:0001525]; chromatin organization [GO:0006325]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of anoikis [GO:2000811]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:24623306}. Note=Associates with chromatin (PubMed:24623306). {ECO:0000269|PubMed:24623306}.
Q9HCX4	reviewed	TRPC7_HUMAN	Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7)	TRPC7 TRP7	Homo sapiens (Human)	862	FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion. {ECO:0000250}.		calcium ion transmembrane transport [GO:0070588]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338]	cation channel complex [GO:0034703]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]	cation channel complex [GO:0034703]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]; calcium ion transmembrane transport [GO:0070588]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21402151}; Multi-pass membrane protein {ECO:0000269|PubMed:21402151}. Nucleus envelope {ECO:0000269|PubMed:21402151}.
Q9HCY8	reviewed	S10AE_HUMAN	Protein S100-A14 (S100 calcium-binding protein A14) (S114)	S100A14 S100A15	Homo sapiens (Human)	104	FUNCTION: Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898, ECO:0000269|PubMed:22451655}.		apoptotic process [GO:0006915]; calcium ion homeostasis [GO:0055074]; defense response to bacterium [GO:0042742]; positive regulation of granulocyte chemotaxis [GO:0071624]; positive regulation of monocyte chemotaxis [GO:0090026]; response to lipopolysaccharide [GO:0032496]; toll-like receptor 4 signaling pathway [GO:0034142]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; chemokine receptor binding [GO:0042379]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; chemokine receptor binding [GO:0042379]; apoptotic process [GO:0006915]; calcium ion homeostasis [GO:0055074]; defense response to bacterium [GO:0042742]; positive regulation of granulocyte chemotaxis [GO:0071624]; positive regulation of monocyte chemotaxis [GO:0090026]; response to lipopolysaccharide [GO:0032496]; toll-like receptor 4 signaling pathway [GO:0034142]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11944983}.
Q9HD15	reviewed	SRA1_HUMAN	Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein) (SRAP)	SRA1 PP7684	Homo sapiens (Human)	224	FUNCTION: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. {ECO:0000269|PubMed:10199399, ECO:0000269|PubMed:12943696, ECO:0000269|PubMed:14517287, ECO:0000269|PubMed:15147866, ECO:0000269|PubMed:15351741}.	MISCELLANEOUS: Appears to be the first example of a new class of functional RNAs also able to encode a protein. {ECO:0000269|PubMed:12565891, ECO:0000269|PubMed:15147866}.	apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to estrogen stimulus [GO:0071391]; negative regulation of myoblast differentiation [GO:0045662]; regulation of apoptotic process [GO:0042981]; regulation of mitotic cell cycle [GO:0007346]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; SCAR complex [GO:0031209]	nuclear receptor coactivator activity [GO:0030374]; steroid receptor RNA activator RNA binding [GO:0002153]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; SCAR complex [GO:0031209]; nuclear receptor coactivator activity [GO:0030374]; steroid receptor RNA activator RNA binding [GO:0002153]; transcription coactivator activity [GO:0003713]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to estrogen stimulus [GO:0071391]; negative regulation of myoblast differentiation [GO:0045662]; regulation of apoptotic process [GO:0042981]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12565891}. Cytoplasm {ECO:0000269|PubMed:12565891}.
Q9HD20	reviewed	AT131_HUMAN	Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase)	ATP13A1 ATP13A KIAA1825 CGI-152	Homo sapiens (Human)	1204	FUNCTION: Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). {ECO:0000269|PubMed:32973005, ECO:0000269|PubMed:36264797}.		extraction of mislocalized protein from ER membrane [GO:0140569]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; protein transport [GO:0015031]; transmembrane transport [GO:0055085]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	ABC-type manganese transporter activity [GO:0015410]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; membrane protein dislocase activity [GO:0140567]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; ABC-type manganese transporter activity [GO:0015410]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; membrane protein dislocase activity [GO:0140567]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; extraction of mislocalized protein from ER membrane [GO:0140569]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; protein transport [GO:0015031]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24392018}; Multi-pass membrane protein {ECO:0000269|PubMed:24392018}.
Q9HD23	reviewed	MRS2_HUMAN	Magnesium transporter MRS2 homolog, mitochondrial (MRS2-like protein)	MRS2 HPT MRS2L	Homo sapiens (Human)	443	FUNCTION: Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665). {ECO:0000269|PubMed:11401429, ECO:0000269|PubMed:18384665}.	MISCELLANEOUS: Has the ability to complement a deletion of MRS2 in S.cerevisiae and partly restore mitochondrial magnesium concentrations.	lactate metabolic process [GO:0006089]; mitochondrial magnesium ion transmembrane transport [GO:0045016]; transmembrane transport [GO:0055085]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	magnesium ion transmembrane transporter activity [GO:0015095]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; magnesium ion transmembrane transporter activity [GO:0015095]; lactate metabolic process [GO:0006089]; mitochondrial magnesium ion transmembrane transport [GO:0045016]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11401429, ECO:0000305|PubMed:18384665}; Multi-pass membrane protein {ECO:0000305}.
Q9HD26	reviewed	GOPC_HUMAN	Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST)	GOPC CAL FIG	Homo sapiens (Human)	462	FUNCTION: Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}.		apical protein localization [GO:0045176]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi to plasma membrane transport [GO:0006893]; negative regulation of anion channel activity [GO:0010360]; negative regulation of protein localization to cell surface [GO:2000009]; protein transport [GO:0015031]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; trans-Golgi network transport vesicle [GO:0030140]	identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; trans-Golgi network transport vesicle [GO:0030140]; identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; transmembrane transporter binding [GO:0044325]; apical protein localization [GO:0045176]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi to plasma membrane transport [GO:0006893]; negative regulation of anion channel activity [GO:0010360]; negative regulation of protein localization to cell surface [GO:2000009]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane {ECO:0000269|PubMed:23818989}; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Synapse {ECO:0000250}. Postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. {ECO:0000250}.
Q9HD34	reviewed	LYRM4_HUMAN	LYR motif-containing protein 4	LYRM4 C6orf149 ISD11 CGI-203	Homo sapiens (Human)	91	FUNCTION: Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:31664822, PubMed:17331979). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1 (PubMed:19454487). {ECO:0000250|UniProtKB:Q9H1K1, ECO:0000269|PubMed:17331979, ECO:0000269|PubMed:19454487, ECO:0000269|PubMed:31664822}.		[2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; iron-sulfur cluster assembly [GO:0016226]	iron-sulfur cluster assembly complex [GO:1990229]; L-cysteine desulfurase complex [GO:1990221]; mitochondrial iron-sulfur cluster assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleus [GO:0005634]	protein homodimerization activity [GO:0042803]	iron-sulfur cluster assembly complex [GO:1990229]; L-cysteine desulfurase complex [GO:1990221]; mitochondrial iron-sulfur cluster assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleus [GO:0005634]; protein homodimerization activity [GO:0042803]; [2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; iron-sulfur cluster assembly [GO:0016226]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:17331979, ECO:0000269|PubMed:19454487, ECO:0000269|PubMed:23593335}. Nucleus {ECO:0000269|PubMed:19454487, ECO:0000269|PubMed:23593335}.
Q9HD36	reviewed	B2L10_HUMAN	Bcl-2-like protein 10 (Bcl2-L-10) (Anti-apoptotic protein Boo) (Anti-apoptotic protein NrH) (Apoptosis regulator Bcl-B)	BCL2L10 BCL-B BCLB BOO DIVA	Homo sapiens (Human)	204	FUNCTION: Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed:11689480, PubMed:11278245). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed:27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (By similarity). {ECO:0000250|UniProtKB:Q9Z0F3, ECO:0000269|PubMed:11278245, ECO:0000269|PubMed:11689480, ECO:0000269|PubMed:27995898}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; female gamete generation [GO:0007292]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; microtubule organizing center organization [GO:0031023]; negative regulation of apoptotic process [GO:0043066]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; spindle [GO:0005819]	calcium ion binding [GO:0005509]; caspase binding [GO:0089720]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; spindle [GO:0005819]; calcium ion binding [GO:0005509]; caspase binding [GO:0089720]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; female gamete generation [GO:0007292]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; microtubule organizing center organization [GO:0031023]; negative regulation of apoptotic process [GO:0043066]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11593390, ECO:0000269|PubMed:21705382, ECO:0000269|PubMed:22233804, ECO:0000269|PubMed:22498477, ECO:0000269|PubMed:23563182}. Nucleus membrane {ECO:0000269|PubMed:11593390}. Endoplasmic reticulum {ECO:0000269|PubMed:22498477, ECO:0000269|PubMed:27995898}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9Z0F3}. Note=Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:27995898). Localization to MAMs is greatly reduced under apoptotic stress conditions (PubMed:27995898). {ECO:0000269|PubMed:27995898}.
Q9HD40	reviewed	SPCS_HUMAN	O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Liver-pancreas antigen) (LP) (SLA-p35) (SLA/LP autoantigen) (Selenocysteine synthase) (Sec synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase) (SepSecS) (Soluble liver antigen) (SLA) (UGA suppressor tRNA-associated protein) (tRNA(Ser/Sec)-associated antigenic protein)	SEPSECS TRNP48	Homo sapiens (Human)	501	FUNCTION: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. {ECO:0000269|PubMed:17142313}.	MISCELLANEOUS: Possible diagnostic marker for autoimmune hepatitis (AIH).; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	conversion of seryl-tRNAsec to selenocys-tRNAsec [GO:0001717]; selenocysteine incorporation [GO:0001514]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	O-phosphoseryl-tRNA(Sec) selenium transferase activity [GO:0098621]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; O-phosphoseryl-tRNA(Sec) selenium transferase activity [GO:0098621]; tRNA binding [GO:0000049]; conversion of seryl-tRNAsec to selenocys-tRNAsec [GO:0001717]; selenocysteine incorporation [GO:0001514]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q9HD42	reviewed	CHM1A_HUMAN	Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1)	CHMP1A CHMP1 KIAA0047 PCOLN3 PRSM1	Homo sapiens (Human)	196	FUNCTION: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. {ECO:0000269|PubMed:11559747, ECO:0000269|PubMed:11559748, ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:23045692}.		autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic chromosome condensation [GO:0007076]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of gene expression [GO:0010629]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; vesicle-mediated transport [GO:0016192]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear matrix [GO:0016363]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear matrix [GO:0016363]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic chromosome condensation [GO:0007076]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of gene expression [GO:0010629]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; vesicle-mediated transport [GO:0016192]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.
Q9HD43	reviewed	PTPRH_HUMAN	Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)	PTPRH SAP1	Homo sapiens (Human)	1115	FUNCTION: Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity). {ECO:0000250|UniProtKB:E9Q0N2, ECO:0000269|PubMed:11278335, ECO:0000269|PubMed:12101188, ECO:0000269|PubMed:12837766, ECO:0000269|PubMed:15850787}.		apoptotic process [GO:0006915]; protein dephosphorylation [GO:0006470]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; microvillus membrane [GO:0031528]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; microvillus membrane [GO:0031528]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; apoptotic process [GO:0006915]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cell projection, microvillus membrane {ECO:0000250|UniProtKB:E9Q0N2}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:E9Q0N2}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12879010}. Note=Colocalizes with CEACAM20 at the apical brush border of intestinal cells. {ECO:0000250|UniProtKB:E9Q0N2}.
Q9HD47	reviewed	MOG1_HUMAN	Ran guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1)	RANGRF MOG1 RANGNRF HSPC165 HSPC236 MDS5	Homo sapiens (Human)	186	FUNCTION: May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375). {ECO:0000269|PubMed:11290418, ECO:0000269|PubMed:18184654, ECO:0000269|PubMed:21621375, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:29040603}.	MISCELLANEOUS: Overexpression can rescue the trafficking defect caused by some SCN5A mutations that impair trafficking to the cell membrane. {ECO:0000269|PubMed:23420830}.	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; heart contraction [GO:0060047]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein exit from endoplasmic reticulum [GO:0032527]; protein import into nucleus [GO:0006606]; regulation of bundle of His cell action potential [GO:0098905]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of heart rate [GO:0002027]; regulation of membrane depolarization [GO:0003254]; regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900825]; regulation of membrane potential [GO:0042391]; regulation of microtubule nucleation by Ran protein signal transduction [GO:0090226]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transmembrane transporter activity [GO:2000649]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercalated disc [GO:0014704]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercalated disc [GO:0014704]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; heart contraction [GO:0060047]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein exit from endoplasmic reticulum [GO:0032527]; protein import into nucleus [GO:0006606]; regulation of bundle of His cell action potential [GO:0098905]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of heart rate [GO:0002027]; regulation of membrane depolarization [GO:0003254]; regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900825]; regulation of membrane potential [GO:0042391]; regulation of microtubule nucleation by Ran protein signal transduction [GO:0090226]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transmembrane transporter activity [GO:2000649]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11290418}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21447824}. Cytoplasm {ECO:0000269|PubMed:11290418, ECO:0000269|PubMed:21447824}. Cell membrane {ECO:0000269|PubMed:21447824}; Peripheral membrane protein {ECO:0000305|PubMed:21447824}; Cytoplasmic side {ECO:0000305|PubMed:21447824}. Note=May shuttle between the nucleus and cytoplasm. {ECO:0000269|PubMed:11290418}.
Q9HD67	reviewed	MYO10_HUMAN	Unconventional myosin-X (Unconventional myosin-10)	MYO10 KIAA0799	Homo sapiens (Human)	2058	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (PubMed:27580874). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893, ECO:0000269|PubMed:27580874}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250|UniProtKB:F8VQB6}.	MISCELLANEOUS: [Isoform Headless]: Produced by alternative promoter usage. {ECO:0000305}.	cytoskeleton-dependent intracellular transport [GO:0030705]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of cell shape [GO:0008360]; regulation of filopodium assembly [GO:0051489]; signal transduction [GO:0007165]	cell cortex [GO:0005938]; cytosol [GO:0005829]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; plus-end directed microfilament motor activity [GO:0060002]; spectrin binding [GO:0030507]	cell cortex [GO:0005938]; cytosol [GO:0005829]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; plus-end directed microfilament motor activity [GO:0060002]; spectrin binding [GO:0030507]; cytoskeleton-dependent intracellular transport [GO:0030705]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of cell shape [GO:0008360]; regulation of filopodium assembly [GO:0051489]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10984435}. Cell projection, lamellipodium {ECO:0000269|PubMed:10984435}. Cell projection, ruffle {ECO:0000269|PubMed:10984435}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10984435}. Cell projection, filopodium tip {ECO:0000269|PubMed:10984435}. Cytoplasm, cell cortex {ECO:0000269|PubMed:10984435}. Cell projection, filopodium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and rearward movements within filopodia. Interacts with microtubules.
Q9HD89	reviewed	RETN_HUMAN	Resistin (Adipose tissue-specific secretory factor) (ADSF) (C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein) (Cysteine-rich secreted protein A12-alpha-like 2) (Cysteine-rich secreted protein FIZZ3)	RETN FIZZ3 HXCP1 RSTN UNQ407/PRO1199	Homo sapiens (Human)	108	FUNCTION: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728). {ECO:0000250|UniProtKB:Q99P87, ECO:0000269|PubMed:15064728}.		fat cell differentiation [GO:0045444]; negative regulation of feeding behavior [GO:2000252]; positive regulation of progesterone secretion [GO:2000872]; positive regulation of synaptic transmission [GO:0050806]; response to insulin [GO:0032868]; response to mechanical stimulus [GO:0009612]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]	hormone activity [GO:0005179]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; hormone activity [GO:0005179]; fat cell differentiation [GO:0045444]; negative regulation of feeding behavior [GO:2000252]; positive regulation of progesterone secretion [GO:2000872]; positive regulation of synaptic transmission [GO:0050806]; response to insulin [GO:0032868]; response to mechanical stimulus [GO:0009612]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q99P87}.
Q9HD90	reviewed	NDF4_HUMAN	Neurogenic differentiation factor 4 (NeuroD4) (Class A basic helix-loop-helix protein 4) (bHLHa4) (Protein atonal homolog 3) (ATH-3) (Atoh3)	NEUROD4 ATH3 ATOH3 BHLHA4	Homo sapiens (Human)	331	FUNCTION: Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity). {ECO:0000250}.		amacrine cell differentiation [GO:0035881]; axon development [GO:0061564]; camera-type eye development [GO:0043010]; cell fate commitment [GO:0045165]; motor neuron migration [GO:0097475]; neuroblast proliferation [GO:0007405]; Notch signaling pathway [GO:0007219]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; amacrine cell differentiation [GO:0035881]; axon development [GO:0061564]; camera-type eye development [GO:0043010]; cell fate commitment [GO:0045165]; motor neuron migration [GO:0097475]; neuroblast proliferation [GO:0007405]; Notch signaling pathway [GO:0007219]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q9HDB5	reviewed	NRX3B_HUMAN	Neurexin-3-beta (Neurexin III-beta) [Cleaved into: Neurexin-3-beta, soluble form; Neurexin-3-beta, C-terminal fragment (NRXN3-CTF)]	NRXN3 KIAA0743	Homo sapiens (Human)	637	FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). {ECO:0000250|UniProtKB:Q9CS84}.	MISCELLANEOUS: [Isoform 2b]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3b]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4b]: Produced by alternative splicing. {ECO:0000305}.	adult behavior [GO:0030534]; angiogenesis [GO:0001525]; learning [GO:0007612]; neuron cell-cell adhesion [GO:0007158]; signal transduction [GO:0007165]; social behavior [GO:0035176]; vocalization behavior [GO:0071625]	cell projection [GO:0042995]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; transmembrane signaling receptor activity [GO:0004888]	cell projection [GO:0042995]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; transmembrane signaling receptor activity [GO:0004888]; adult behavior [GO:0030534]; angiogenesis [GO:0001525]; learning [GO:0007612]; neuron cell-cell adhesion [GO:0007158]; signal transduction [GO:0007165]; social behavior [GO:0035176]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9HDC5	reviewed	JPH1_HUMAN	Junctophilin-1 (JP-1) (Junctophilin type 1)	JPH1 JP1	Homo sapiens (Human)	661	FUNCTION: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.		calcium ion transport into cytosol [GO:0060402]; muscle organ development [GO:0007517]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]	endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; Z disc [GO:0030018]	structural constituent of muscle [GO:0008307]	endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; Z disc [GO:0030018]; structural constituent of muscle [GO:0008307]; calcium ion transport into cytosol [GO:0060402]; muscle organ development [GO:0007517]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Sarcoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands (By similarity). {ECO:0000250}.
Q9HDC9	reviewed	APMAP_HUMAN	Adipocyte plasma membrane-associated protein (Protein BSCv)	APMAP C20orf3 UNQ1869/PRO4305	Homo sapiens (Human)	416	FUNCTION: Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation. {ECO:0000269|PubMed:18513186}.		biosynthetic process [GO:0009058]	cell surface [GO:0009986]; membrane [GO:0016020]	arylesterase activity [GO:0004064]; strictosidine synthase activity [GO:0016844]	cell surface [GO:0009986]; membrane [GO:0016020]; arylesterase activity [GO:0004064]; strictosidine synthase activity [GO:0016844]; biosynthetic process [GO:0009058]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:18513186}; Single-pass type II membrane protein {ECO:0000269|PubMed:18513186}.
Q9HDD0	reviewed	PLAT1_HUMAN	Phospholipase A and acyltransferase 1 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 1) (HRSL1) (Phospholipid-metabolizing enzyme A-C1)	PLAAT1 HRASLS	Homo sapiens (Human)	168	FUNCTION: Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:21880860, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:21880860, PubMed:22825852, PubMed:27623847). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:21880860). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (PubMed:21880860, PubMed:22825852, PubMed:27623847). {ECO:0000269|PubMed:21880860, ECO:0000269|PubMed:22825852, ECO:0000269|PubMed:27623847, ECO:0000303|PubMed:26503625}.		lens fiber cell differentiation [GO:0070306]; lipid catabolic process [GO:0016042]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; organelle disassembly [GO:1903008]; phosphatidylcholine metabolic process [GO:0046470]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear envelope lumen [GO:0005641]; nucleus [GO:0005634]	1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; N-acyltransferase activity [GO:0016410]; O-acyltransferase activity [GO:0008374]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear envelope lumen [GO:0005641]; nucleus [GO:0005634]; 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; N-acyltransferase activity [GO:0016410]; O-acyltransferase activity [GO:0008374]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]; lens fiber cell differentiation [GO:0070306]; lipid catabolic process [GO:0016042]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; organelle disassembly [GO:1903008]; phosphatidylcholine metabolic process [GO:0046470]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:27623847}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:27623847}. Cytoplasm {ECO:0000269|PubMed:27623847}.
Q9N2K0	reviewed	ENH1_HUMAN	HERV-H_2q24.3 provirus ancestral Env polyprotein (Env protein HERV-H/p62) (Env protein HERV-H19) (Env protein HERV-Hcl.3) (Envelope polyprotein) (HERV-H/env62) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]		Homo sapiens (Human)	584	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties but has immunosuppressive properties in vivo. {ECO:0000269|PubMed:11562544, ECO:0000269|PubMed:14557543}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: Ortholog in Pan troglodytes.; MISCELLANEOUS: HERV-H family subgenomic RNAs have been observed.; MISCELLANEOUS: This provirus is intergenic, the closest flanking genes being TAIP2 and GALNT3.	syncytium formation by plasma membrane fusion [GO:0000768]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; syncytium formation by plasma membrane fusion [GO:0000768]	SUBCELLULAR LOCATION: Virion.; SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NNW5	reviewed	WDR6_HUMAN	tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6)	WDR6	Homo sapiens (Human)	1121	FUNCTION: Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Required for the correct positioning of the substrate tRNA for methylation (PubMed:32558197). Required to suppress amino acid starvation-induced autophagy (PubMed:22354037). Enhances the STK11/LKB1-induced cell growth suppression activity (PubMed:17216128). {ECO:0000269|PubMed:17216128, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:32558197, ECO:0000269|PubMed:33771871}.		G1 to G0 transition [GO:0070314]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; tRNA methylation [GO:0030488]; wobble position ribose methylation [GO:0002130]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	enzyme regulator activity [GO:0030234]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; enzyme regulator activity [GO:0030234]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]; G1 to G0 transition [GO:0070314]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; tRNA methylation [GO:0030488]; wobble position ribose methylation [GO:0002130]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17216128}. Note=Colocalizes in the cytoplasm with STK11/LKB1. {ECO:0000269|PubMed:17216128}.
Q9NNW7	reviewed	TRXR2_HUMAN	Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Selenoprotein Z) (SelZ) (TR-beta) (Thioredoxin reductase TR3)	TXNRD2 KIAA1652 TRXR2	Homo sapiens (Human)	524	FUNCTION: Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. {ECO:0000250|UniProtKB:Q9Z0J5, ECO:0000269|PubMed:24601690}.	MISCELLANEOUS: The active site is a redox-active disulfide bond. The selenocysteine residue is essential for enzymatic activity (By similarity). {ECO:0000250}.	cell redox homeostasis [GO:0045454]; response to hyperoxia [GO:0055093]; response to oxygen radical [GO:0000305]; response to selenium ion [GO:0010269]; response to xenobiotic stimulus [GO:0009410]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]	flavin adenine dinucleotide binding [GO:0050660]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; flavin adenine dinucleotide binding [GO:0050660]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791]; cell redox homeostasis [GO:0045454]; response to hyperoxia [GO:0055093]; response to oxygen radical [GO:0000305]; response to selenium ion [GO:0010269]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10215850}.
Q9NNX6	reviewed	CD209_HUMAN	CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209)	CD209 CLEC4L	Homo sapiens (Human)	404	FUNCTION: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. {ECO:0000269|PubMed:11859097}.; FUNCTION: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. {ECO:0000269|PubMed:10721995, ECO:0000269|PubMed:11017109, ECO:0000269|PubMed:12574325}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2. {ECO:0000269|PubMed:11799126, ECO:0000269|PubMed:12502850, ECO:0000269|PubMed:1518869}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Ebolavirus. {ECO:0000269|PubMed:12502850, ECO:0000269|PubMed:12504546}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Cytomegalovirus. {ECO:0000269|PubMed:12433371, ECO:0000269|PubMed:22496863}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for HCV. {ECO:0000269|PubMed:15371595, ECO:0000269|PubMed:16816373}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Dengue virus. {ECO:0000269|PubMed:12682107}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Measles virus. {ECO:0000269|PubMed:16537615}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1. {ECO:0000269|PubMed:18796707}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Influenzavirus A. {ECO:0000269|PubMed:21191006}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for SARS-CoV. {ECO:0000269|PubMed:15140961}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. {ECO:0000269|PubMed:24623090}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Lassa virus (PubMed:23966408). Acts as an attachment receptor for Marburg virusn. {ECO:0000269|PubMed:15479853}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus. {ECO:0000269|PubMed:22090124}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus. {ECO:0000269|PubMed:21767814}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for West-nile virus. {ECO:0000269|PubMed:16415006}.; FUNCTION: (Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498). Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928). {ECO:0000269|PubMed:16092920, ECO:0000269|PubMed:16379498, ECO:0000269|PubMed:21203928}.	MISCELLANEOUS: In vitro, is a receptor for HIV-1 and transmits HIV-1 either in trans without DC infection, or in cis following a DC infection to permissive T-cells to induce a robust infection. Bound HIV-1 remains infectious over a prolonged period of time and it is proposed that bound HIV-1 is not degraded but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the HIV-1 infectious potential during transport by DCs from the periphery to lymphoid organs.; MISCELLANEOUS: [Isoform 9]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; B cell adhesion [GO:0097323]; cell-cell recognition [GO:0009988]; endocytosis [GO:0006897]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intracellular transport of virus [GO:0075733]; leukocyte cell-cell adhesion [GO:0007159]; peptide antigen transport [GO:0046968]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of viral life cycle [GO:1903902]; regulation of T cell proliferation [GO:0042129]; viral entry into host cell [GO:0046718]; viral genome replication [GO:0019079]; virion attachment to host cell [GO:0019062]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; host cell [GO:0043657]; membrane [GO:0016020]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]; peptide antigen binding [GO:0042605]; virion binding [GO:0046790]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; host cell [GO:0043657]; membrane [GO:0016020]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; mannose binding [GO:0005537]; metal ion binding [GO:0046872]; peptide antigen binding [GO:0042605]; virion binding [GO:0046790]; virus receptor activity [GO:0001618]; adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; B cell adhesion [GO:0097323]; cell-cell recognition [GO:0009988]; endocytosis [GO:0006897]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intracellular transport of virus [GO:0075733]; leukocyte cell-cell adhesion [GO:0007159]; peptide antigen transport [GO:0046968]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of viral life cycle [GO:1903902]; regulation of T cell proliferation [GO:0042129]; viral entry into host cell [GO:0046718]; viral genome replication [GO:0019079]; virion attachment to host cell [GO:0019062]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 9]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 10]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 11]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 12]: Secreted {ECO:0000305}.
Q9NP31	reviewed	SH22A_HUMAN	SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)	SH2D2A SCAP TSAD VRAP	Homo sapiens (Human)	389	FUNCTION: Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.		angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; signal transduction [GO:0007165]; T cell proliferation [GO:0042098]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; SH3 domain binding [GO:0017124]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; signal transduction [GO:0007165]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Cytoplasm.
Q9NP50	reviewed	SHCAF_HUMAN	SIN3-HDAC complex-associated factor (Protein FAM60A) (Tera protein homolog)	SINHCAF C12orf14 FAM60A L4	Homo sapiens (Human)	221	FUNCTION: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity). {ECO:0000250|UniProtKB:Q8C8M1, ECO:0000269|PubMed:22865885, ECO:0000269|PubMed:22984288}.		negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459]	nucleus [GO:0005634]; Sin3 complex [GO:0016580]		nucleus [GO:0005634]; Sin3 complex [GO:0016580]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8C8M1}.
Q9NP55	reviewed	BPIA1_HUMAN	BPI fold-containing family A member 1 (Lung-specific protein X) (Nasopharyngeal carcinoma-related protein) (Palate lung and nasal epithelium clone protein) (Secretory protein in upper respiratory tracts) (Short PLUNC1) (SPLUNC1) (Tracheal epithelium-enriched protein) (Von Ebner protein Hl)	BPIFA1 LUNX NASG PLUNC SPLUNC1 SPURT UNQ787/PRO1606	Homo sapiens (Human)	256	FUNCTION: Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608). Plays a role in the innate immune responses of the upper airways (PubMed:23499554, PubMed:23132494). Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554, PubMed:23132494, PubMed:27145151). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24124190, PubMed:24043776). Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234). May attract macrophages and neutrophils (PubMed:23132494). {ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:23132494, ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190, ECO:0000269|PubMed:25223608, ECO:0000269|PubMed:27145151}.		antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to virus [GO:0051607]; immune response in nasopharyngeal-associated lymphoid tissue [GO:0002395]; innate immune response [GO:0045087]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of single-species biofilm formation in or on host organism [GO:1900229]; regulation of sodium ion transmembrane transport [GO:1902305]; surfactant homeostasis [GO:0043129]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	lipid binding [GO:0008289]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; lipid binding [GO:0008289]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to virus [GO:0051607]; immune response in nasopharyngeal-associated lymphoid tissue [GO:0002395]; innate immune response [GO:0045087]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of single-species biofilm formation in or on host organism [GO:1900229]; regulation of sodium ion transmembrane transport [GO:1902305]; surfactant homeostasis [GO:0043129]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:12409287, ECO:0000269|PubMed:12920053, ECO:0000269|PubMed:15158712, ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190, ECO:0000269|PubMed:26559477}. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
Q9NP56	reviewed	PDE7B_HUMAN	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.53)	PDE7B	Homo sapiens (Human)	450	FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:10814504, PubMed:10872825). May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain (PubMed:10814504). {ECO:0000269|PubMed:10814504, ECO:0000269|PubMed:10872825}.		cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; chemical synaptic transmission [GO:0007268]; signal transduction [GO:0007165]	cytosol [GO:0005829]; synapse [GO:0045202]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; synapse [GO:0045202]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]; cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; chemical synaptic transmission [GO:0007268]; signal transduction [GO:0007165]	
Q9NP58	reviewed	ABCB6_HUMAN	ATP-binding cassette sub-family B member 6 (ABC-type heme transporter ABCB6) (EC 7.6.2.5) (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (P-glycoprotein-related protein) (Ubiquitously-expressed mammalian ABC half transporter)	ABCB6 MTABC3 PRP UMAT	Homo sapiens (Human)	842	FUNCTION: ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed:33007128, PubMed:27507172, PubMed:17661442, PubMed:23792964). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed:17006453, PubMed:10837493, PubMed:23792964, PubMed:33007128). May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (PubMed:29940187). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (PubMed:25202056, PubMed:21266531, PubMed:31053883). In addition may play a role in the transition metal homeostasis (By similarity). {ECO:0000250|UniProtKB:O70595, ECO:0000269|PubMed:10837493, ECO:0000269|PubMed:17006453, ECO:0000269|PubMed:17661442, ECO:0000269|PubMed:21266531, ECO:0000269|PubMed:23792964, ECO:0000269|PubMed:25202056, ECO:0000269|PubMed:27507172, ECO:0000269|PubMed:29940187, ECO:0000269|PubMed:31053883, ECO:0000269|PubMed:33007128}.		brain development [GO:0007420]; cellular detoxification of cadmium ion [GO:0098849]; heme metabolic process [GO:0042168]; heme transmembrane transport [GO:0035351]; heme transport [GO:0015886]; intracellular copper ion homeostasis [GO:0006878]; intracellular iron ion homeostasis [GO:0006879]; melanosome assembly [GO:1903232]; porphyrin-containing compound biosynthetic process [GO:0006779]; porphyrin-containing compound metabolic process [GO:0006778]; skin development [GO:0043588]; tetrapyrrole metabolic process [GO:0033013]; transmembrane transport [GO:0055085]	ATP-binding cassette (ABC) transporter complex [GO:0043190]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome membrane [GO:0033162]; mitochondrial envelope [GO:0005740]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body membrane [GO:0032585]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]	ABC-type heme transporter activity [GO:0015439]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; efflux transmembrane transporter activity [GO:0015562]; heme binding [GO:0020037]; tetrapyrrole binding [GO:0046906]	ATP-binding cassette (ABC) transporter complex [GO:0043190]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome membrane [GO:0033162]; mitochondrial envelope [GO:0005740]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body membrane [GO:0032585]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]; ABC-type heme transporter activity [GO:0015439]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; efflux transmembrane transporter activity [GO:0015562]; heme binding [GO:0020037]; tetrapyrrole binding [GO:0046906]; brain development [GO:0007420]; cellular detoxification of cadmium ion [GO:0098849]; heme metabolic process [GO:0042168]; heme transmembrane transport [GO:0035351]; heme transport [GO:0015886]; intracellular copper ion homeostasis [GO:0006878]; intracellular iron ion homeostasis [GO:0006879]; melanosome assembly [GO:1903232]; porphyrin-containing compound biosynthetic process [GO:0006779]; porphyrin-containing compound metabolic process [GO:0006778]; skin development [GO:0043588]; tetrapyrrole metabolic process [GO:0033013]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17661442, ECO:0000269|PubMed:22246506, ECO:0000269|PubMed:22655043, ECO:0000269|PubMed:23180570, ECO:0000269|PubMed:27507172}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000269|PubMed:17006453, ECO:0000269|PubMed:17661442}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18279659, ECO:0000269|PubMed:21199866, ECO:0000269|PubMed:22226084}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:18279659, ECO:0000269|PubMed:21199866, ECO:0000269|PubMed:22226084}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:25627919}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:22655043, ECO:0000269|PubMed:25627919, ECO:0000269|PubMed:29940187, ECO:0000269|PubMed:31053883}. Late endosome membrane {ECO:0000250|UniProtKB:O70595}. Early endosome membrane {ECO:0000250|UniProtKB:O70595}. Secreted, extracellular exosome {ECO:0000269|PubMed:22655043}. Mitochondrion {ECO:0000269|PubMed:10837493, ECO:0000269|PubMed:23792964}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:25627919}. Melanosome membrane {ECO:0000269|PubMed:29940187}. Note=Present in the membrane of mature erythrocytes and in exosomes released from reticulocytes during the final steps of erythroid maturation (PubMed:22655043). Traffics from endoplasmic reticulum to Golgi during its glycans's maturation, therefrom is first targeted to the plasma membrane, and is rapidly internalized through endocytosis to be distributed to the limiting membrane of multivesicular bodies and lysosomes (PubMed:25627919, PubMed:21199866, PubMed:18279659). Localized on the limiting membrane of early melanosomes of pigment cells (PubMed:29940187). Targeted to the endolysosomal compartment (By similarity). {ECO:0000250|UniProtKB:O70595, ECO:0000269|PubMed:18279659, ECO:0000269|PubMed:21199866, ECO:0000269|PubMed:22655043, ECO:0000269|PubMed:25627919, ECO:0000269|PubMed:29940187}.
Q9NP59	reviewed	S40A1_HUMAN	Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1)	SLC40A1 FPN FPN1 IREG1 SLC11A3 MSTP079	Homo sapiens (Human)	571	FUNCTION: Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:15692071, PubMed:24304836, PubMed:22178646, PubMed:29599243, PubMed:30247984, PubMed:22682227, PubMed:29237594). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342). {ECO:0000250|UniProtKB:Q9JHI9, ECO:0000269|PubMed:15692071, ECO:0000269|PubMed:22178646, ECO:0000269|PubMed:22682227, ECO:0000269|PubMed:24304836, ECO:0000269|PubMed:29237594, ECO:0000269|PubMed:29599243, ECO:0000269|PubMed:30247984, ECO:0000269|PubMed:32814342}.		apoptotic process [GO:0006915]; endothelium development [GO:0003158]; establishment of localization in cell [GO:0051649]; intracellular iron ion homeostasis [GO:0006879]; iron ion export across plasma membrane [GO:1903988]; iron ion transmembrane transport [GO:0034755]; lymphocyte homeostasis [GO:0002260]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription from RNA polymerase II promoter in response to iron [GO:0034395]; spleen trabecula formation [GO:0060345]; transcription by RNA polymerase II [GO:0006366]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	ferrous iron transmembrane transporter activity [GO:0015093]; identical protein binding [GO:0042802]; iron ion transmembrane transporter activity [GO:0005381]; metal ion binding [GO:0046872]; peptide hormone binding [GO:0017046]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; ferrous iron transmembrane transporter activity [GO:0015093]; identical protein binding [GO:0042802]; iron ion transmembrane transporter activity [GO:0005381]; metal ion binding [GO:0046872]; peptide hormone binding [GO:0017046]; apoptotic process [GO:0006915]; endothelium development [GO:0003158]; establishment of localization in cell [GO:0051649]; intracellular iron ion homeostasis [GO:0006879]; iron ion export across plasma membrane [GO:1903988]; iron ion transmembrane transport [GO:0034755]; lymphocyte homeostasis [GO:0002260]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription from RNA polymerase II promoter in response to iron [GO:0034395]; spleen trabecula formation [GO:0060345]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10882071, ECO:0000269|PubMed:15692071, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:24304836, ECO:0000269|PubMed:29237594, ECO:0000269|PubMed:30247984}; Multi-pass membrane protein {ECO:0000269|PubMed:32814342}. Basolateral cell membrane {ECO:0000269|PubMed:29792530}; Multi-pass membrane protein {ECO:0000269|PubMed:32814342}. Note=Localized to the basolateral membrane of hepatocytoma WIF-B cells. {ECO:0000269|PubMed:29792530}.
Q9NP60	reviewed	IRPL2_HUMAN	X-linked interleukin-1 receptor accessory protein-like 2 (IL-1 receptor accessory protein-like 2) (IL-1-RAPL-2) (IL-1RAPL-2) (IL1RAPL-2) (EC 3.2.2.6) (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R-9) (IL-1R9) (Three immunoglobulin domain-containing IL-1 receptor-related 1) (TIGIRR-1)	IL1RAPL2 IL1R9	Homo sapiens (Human)	686			central nervous system development [GO:0007417]; regulation of presynapse assembly [GO:1905606]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]	interleukin-1 receptor activity [GO:0004908]; interleukin-1, type II, blocking receptor activity [GO:0004910]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; interleukin-1 receptor activity [GO:0004908]; interleukin-1, type II, blocking receptor activity [GO:0004910]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; central nervous system development [GO:0007417]; regulation of presynapse assembly [GO:1905606]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9NP61	reviewed	ARFG3_HUMAN	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3)	ARFGAP3 ARFGAP1	Homo sapiens (Human)	516	FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}.		COPI coating of Golgi vesicle [GO:0048205]; intracellular protein transport [GO:0006886]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; COPI coating of Golgi vesicle [GO:0048205]; intracellular protein transport [GO:0006886]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17760859}. Golgi apparatus membrane {ECO:0000269|PubMed:17760859}; Peripheral membrane protein {ECO:0000269|PubMed:17760859}; Cytoplasmic side {ECO:0000269|PubMed:17760859}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.
Q9NP62	reviewed	GCM1_HUMAN	Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1)	GCM1 GCMA	Homo sapiens (Human)	436	FUNCTION: Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}.		anatomical structure morphogenesis [GO:0009653]; astrocyte fate commitment [GO:0060018]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cell differentiation involved in embryonic placenta development [GO:0060706]; gliogenesis [GO:0042063]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of syncytium formation by plasma membrane fusion [GO:0060143]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; syncytium formation by plasma membrane fusion [GO:0000768]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; anatomical structure morphogenesis [GO:0009653]; astrocyte fate commitment [GO:0060018]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cell differentiation involved in embryonic placenta development [GO:0060706]; gliogenesis [GO:0042063]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of syncytium formation by plasma membrane fusion [GO:0060143]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; syncytium formation by plasma membrane fusion [GO:0000768]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00245}.
Q9NP64	reviewed	ZCC17_HUMAN	Zinc finger CCHC domain-containing protein 17 (Nucleolar protein of 40 kDa) (pNO40) (Pnn-interacting nucleolar protein) (Putative S1 RNA-binding domain protein) (PS1D protein)	ZCCHC17 PS1D HSPC243 HSPC251 LDC4	Homo sapiens (Human)	241			RNA stabilization [GO:0043489]	cytosolic large ribosomal subunit [GO:0022625]; nucleolus [GO:0005730]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytosolic large ribosomal subunit [GO:0022625]; nucleolus [GO:0005730]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; RNA stabilization [GO:0043489]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12893261}.
Q9NP66	reviewed	HM20A_HUMAN	High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1)	HMG20A HMGX1 HMGXB1	Homo sapiens (Human)	347	FUNCTION: Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity). {ECO:0000250}.		chromatin organization [GO:0006325]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]	nucleus [GO:0005634]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]	nucleus [GO:0005634]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; chromatin organization [GO:0006325]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Q9NP70	reviewed	AMBN_HUMAN	Ameloblastin	AMBN	Homo sapiens (Human)	447	FUNCTION: Involved in the mineralization and structural organization of enamel.		biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; odontogenesis of dentin-containing tooth [GO:0042475]; regulation of cell population proliferation [GO:0042127]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]	growth factor activity [GO:0008083]; structural constituent of tooth enamel [GO:0030345]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; growth factor activity [GO:0008083]; structural constituent of tooth enamel [GO:0030345]; biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; odontogenesis of dentin-containing tooth [GO:0042475]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q9NP71	reviewed	MLXPL_HUMAN	Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein)	MLXIPL BHLHD14 MIO WBSCR14	Homo sapiens (Human)	852	FUNCTION: Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	anatomical structure morphogenesis [GO:0009653]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; glucose mediated signaling pathway [GO:0010255]; lipid biosynthetic process [GO:0008610]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; triglyceride homeostasis [GO:0070328]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	carbohydrate response element binding [GO:0035538]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; carbohydrate response element binding [GO:0035538]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; anatomical structure morphogenesis [GO:0009653]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; glucose mediated signaling pathway [GO:0010255]; lipid biosynthetic process [GO:0008610]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Nucleus.
Q9NP72	reviewed	RAB18_HUMAN	Ras-related protein Rab-18	RAB18	Homo sapiens (Human)	206	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:24891604, PubMed:30970241). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:24891604, PubMed:30970241). Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed:30970241). Also required for maintaining endoplasmic reticulum structure (PubMed:24891604). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985). {ECO:0000250|UniProtKB:P35293, ECO:0000269|PubMed:21473985, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:30970241}.	MISCELLANEOUS: [Isoform 2]: Highly expressed in testis. {ECO:0000305}.	brain development [GO:0007420]; endoplasmic reticulum tubular network organization [GO:0071786]; eye development [GO:0001654]; intracellular protein transport [GO:0006886]; lipid droplet organization [GO:0034389]; small GTPase mediated signal transduction [GO:0007264]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; brain development [GO:0007420]; endoplasmic reticulum tubular network organization [GO:0071786]; eye development [GO:0001654]; intracellular protein transport [GO:0006886]; lipid droplet organization [GO:0034389]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P35293}. Lipid droplet {ECO:0000269|PubMed:23935497, ECO:0000269|PubMed:30970241}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24891604}.
Q9NP73	reviewed	ALG13_HUMAN	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (EC 2.4.1.141) (EC 3.4.19.12) (Asparagine-linked glycosylation 13 homolog) (Glycosyltransferase 28 domain-containing protein 1) (UDP-N-acetylglucosamine transferase subunit ALG13 homolog)	ALG13 CXorf45 GLT28D1 MDS031	Homo sapiens (Human)	1137	FUNCTION: [Isoform 1]: Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities.; FUNCTION: [Isoform 2]: May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; proteolysis [GO:0006508]	endoplasmic reticulum membrane [GO:0005789]	cysteine-type deubiquitinase activity [GO:0004843]; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [GO:0004577]; RNA binding [GO:0003723]	endoplasmic reticulum membrane [GO:0005789]; cysteine-type deubiquitinase activity [GO:0004843]; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [GO:0004577]; RNA binding [GO:0003723]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum {ECO:0000305}. Note=Could be recruited to the cytosolic face of the endoplasmic reticulum membrane through its interaction with ALG14.
Q9NP74	reviewed	PALMD_HUMAN	Palmdelphin (Paralemmin-like protein)	PALMD C1orf11 PALML	Homo sapiens (Human)	551			regulation of cell shape [GO:0008360]	cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; membrane [GO:0016020]		cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; membrane [GO:0016020]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11707320}. Cell projection, dendrite {ECO:0000269|PubMed:11707320}. Cell projection, dendritic spine {ECO:0000250}.
Q9NP77	reviewed	SSU72_HUMAN	RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16)	SSU72 HSPC182 PNAS-120	Homo sapiens (Human)	194	FUNCTION: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. {ECO:0000269|PubMed:15659578, ECO:0000269|PubMed:20861839, ECO:0000269|PubMed:23070812}.		mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]	myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly in the cytosol.
Q9NP78	reviewed	ABCB9_HUMAN	ABC-type oligopeptide transporter ABCB9 (EC 7.4.2.6) (ATP-binding cassette sub-family B member 9) (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL)	ABCB9 KIAA1520	Homo sapiens (Human)	766	FUNCTION: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation (PubMed:15863492, PubMed:17977821, PubMed:18434309, PubMed:22641697, PubMed:25646430, PubMed:30877195, PubMed:31417173, PubMed:30353140). Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers (PubMed:15863492, PubMed:25646430). Binds and transports smaller and larger peptides with the same affinity (PubMed:31417173). Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (PubMed:15863492, PubMed:17977821, PubMed:18434309). {ECO:0000269|PubMed:15863492, ECO:0000269|PubMed:17977821, ECO:0000269|PubMed:18434309, ECO:0000269|PubMed:22641697, ECO:0000269|PubMed:25646430, ECO:0000269|PubMed:30353140, ECO:0000269|PubMed:30877195, ECO:0000269|PubMed:31417173}.		peptide metabolic process [GO:0006518]; peptide transport [GO:0015833]; protein transport [GO:0015031]; transmembrane transport [GO:0055085]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]	ABC-type oligopeptide transporter activity [GO:0015421]; ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; protein homodimerization activity [GO:0042803]; transmembrane transporter activity [GO:0022857]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; ABC-type oligopeptide transporter activity [GO:0015421]; ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; protein homodimerization activity [GO:0042803]; transmembrane transporter activity [GO:0022857]; peptide metabolic process [GO:0006518]; peptide transport [GO:0015833]; protein transport [GO:0015031]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:10748049, ECO:0000269|PubMed:15577206, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:17977821, ECO:0000269|PubMed:18175933, ECO:0000269|PubMed:18952056, ECO:0000269|PubMed:20377823, ECO:0000269|PubMed:21212514, ECO:0000269|PubMed:22641697, ECO:0000269|PubMed:30877195}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:10748049, ECO:0000269|PubMed:15577206, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:17977821, ECO:0000269|PubMed:18175933, ECO:0000269|PubMed:18952056, ECO:0000269|PubMed:20377823, ECO:0000269|PubMed:21212514}. Note=May be located in membrane rafts. Takes an intracellular route from the endoplasmic reticulum (ER), via Golgi and early endosomes to late endosomal and lysosomal compartments (PubMed:30877195). {ECO:0000269|PubMed:30877195}.
Q9NP79	reviewed	VTA1_HUMAN	Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1)	VTA1 C6orf55 HSPC228 My012	Homo sapiens (Human)	307	FUNCTION: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding. {ECO:0000250, ECO:0000269|PubMed:15644320}.		ESCRT III complex disassembly [GO:1904903]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; protein transport [GO:0015031]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; ESCRT III complex disassembly [GO:1904903]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15644320}. Endosome membrane {ECO:0000305|PubMed:15644320}; Peripheral membrane protein {ECO:0000305|PubMed:15644320}.
Q9NP80	reviewed	PLPL8_HUMAN	Calcium-independent phospholipase A2-gamma (EC 3.1.1.-) (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (PNPLA-gamma) (Patatin-like phospholipase domain-containing protein 8) (iPLA2-2)	PNPLA8 IPLA22 IPLA2G BM-043	Homo sapiens (Human)	782	FUNCTION: Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors (PubMed:10833412, PubMed:10744668, PubMed:15695510, PubMed:15908428, PubMed:17213206, PubMed:18171998, PubMed:28442572). Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former (PubMed:15695510). Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine (PubMed:10833412, PubMed:10744668, PubMed:15695510, PubMed:15908428). However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling (PubMed:15908428). On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates (PubMed:15908428). Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers (PubMed:15695510, PubMed:15908428). Can also hydrolyze lysophosphatidylcholine (PubMed:15695510). In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition (PubMed:28442572). {ECO:0000250|UniProtKB:Q8K1N1, ECO:0000269|PubMed:10744668, ECO:0000269|PubMed:10833412, ECO:0000269|PubMed:15695510, ECO:0000269|PubMed:15908428, ECO:0000269|PubMed:17213206, ECO:0000269|PubMed:18171998, ECO:0000269|PubMed:28442572}.		arachidonic acid metabolic process [GO:0019369]; arachidonic acid secretion [GO:0050482]; cardiolipin metabolic process [GO:0032048]; fatty acid metabolic process [GO:0006631]; intracellular signal transduction [GO:0035556]; linoleic acid metabolic process [GO:0043651]; lipid homeostasis [GO:0055088]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338]; prostaglandin biosynthetic process [GO:0001516]; regulation of cellular response to oxidative stress [GO:1900407]; triglyceride homeostasis [GO:0070328]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	ATP binding [GO:0005524]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; phospholipase A1 activity [GO:0008970]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; ATP binding [GO:0005524]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; phospholipase A1 activity [GO:0008970]; arachidonic acid metabolic process [GO:0019369]; arachidonic acid secretion [GO:0050482]; cardiolipin metabolic process [GO:0032048]; fatty acid metabolic process [GO:0006631]; intracellular signal transduction [GO:0035556]; linoleic acid metabolic process [GO:0043651]; lipid homeostasis [GO:0055088]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338]; prostaglandin biosynthetic process [GO:0001516]; regulation of cellular response to oxidative stress [GO:1900407]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5XTS1}; Single-pass membrane protein {ECO:0000305|PubMed:10744668, ECO:0000305|PubMed:10833412}. Mitochondrion membrane {ECO:0000305|PubMed:17213206}; Single-pass membrane protein {ECO:0000305|PubMed:10744668, ECO:0000305|PubMed:10833412}. Peroxisome membrane {ECO:0000269|PubMed:15695510}; Single-pass membrane protein {ECO:0000305|PubMed:10744668, ECO:0000305|PubMed:10833412}.
Q9NP81	reviewed	SYSM_HUMAN	Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)	SARS2 SARSM	Homo sapiens (Human)	518	FUNCTION: Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). {ECO:0000250|UniProtKB:Q9N0F3}.		mitochondrial seryl-tRNA aminoacylation [GO:0070158]; seryl-tRNA aminoacylation [GO:0006434]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; RNA binding [GO:0003723]; serine-tRNA ligase activity [GO:0004828]; tRNA binding [GO:0000049]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; RNA binding [GO:0003723]; serine-tRNA ligase activity [GO:0004828]; tRNA binding [GO:0000049]; mitochondrial seryl-tRNA aminoacylation [GO:0070158]; seryl-tRNA aminoacylation [GO:0006434]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q9N0F3}.
Q9NP84	reviewed	TNR12_HUMAN	Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266)	TNFRSF12A FN14	Homo sapiens (Human)	129	FUNCTION: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269|PubMed:11728344}.		angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; regulation of wound healing [GO:0061041]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; regulation of wound healing [GO:0061041]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9NP85	reviewed	PODO_HUMAN	Podocin	NPHS2	Homo sapiens (Human)	383	FUNCTION: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.		actin cytoskeleton organization [GO:0030036]; glomerular filtration [GO:0003094]; metanephric podocyte development [GO:0072249]	cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; slit diaphragm [GO:0036057]		cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; slit diaphragm [GO:0036057]; actin cytoskeleton organization [GO:0030036]; glomerular filtration [GO:0003094]; metanephric podocyte development [GO:0072249]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum {ECO:0000269|PubMed:23648087}.
Q9NP86	reviewed	CABP5_HUMAN	Calcium-binding protein 5 (CaBP5)	CABP5 CABP3	Homo sapiens (Human)	173	FUNCTION: Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (By similarity). Involved in the transmission of light signals (By similarity). May positively regulate neurotransmitter vesicle endocytosis and exocytosis in a salt-dependent manner (By similarity). May play a role in the extension and network organization of neurites (By similarity). {ECO:0000250|UniProtKB:Q9JLK3}.		signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19338761}.
Q9NP87	reviewed	DPOLM_HUMAN	DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase)	POLM polmu	Homo sapiens (Human)	494	FUNCTION: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. {ECO:0000269|PubMed:12640116, ECO:0000269|PubMed:12888504, ECO:0000269|PubMed:17483519, ECO:0000269|PubMed:17915942}.	MISCELLANEOUS: DPOLM has a reduced ability to distinguish dNTP and rNTP as substrates, and elongates them on DNA primer strand with a similar efficiency. It is able to polymerize nucleotides on RNA primer strands.	DNA recombination [GO:0006310]; double-strand break repair via nonhomologous end joining [GO:0006303]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; DNA recombination [GO:0006310]; double-strand break repair via nonhomologous end joining [GO:0006303]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9NP90	reviewed	RAB9B_HUMAN	Ras-related protein Rab-9B (Rab-9-like protein) (Rab-9L)	RAB9B RAB9L	Homo sapiens (Human)	201	FUNCTION: Involved in the transport of proteins between the endosomes and the trans Golgi network. {ECO:0000250|UniProtKB:P24408}.		protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; late endosome [GO:0005770]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; late endosome [GO:0005770]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
Q9NP91	reviewed	S6A20_HUMAN	Sodium- and chloride-dependent transporter XTRP3 (Sodium/imino-acid transporter 1) (Solute carrier family 6 member 20) (Transporter rB21A homolog)	SLC6A20 SIT1 XT3 XTRP3	Homo sapiens (Human)	592	FUNCTION: Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids (PubMed:15632147, PubMed:19033659, PubMed:33428810). Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (PubMed:33428810). {ECO:0000269|PubMed:15632147, ECO:0000269|PubMed:19033659, ECO:0000269|PubMed:33428810}.		amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; amino-acid betaine transport [GO:0015838]; glycine import across plasma membrane [GO:1903804]; glycine transport [GO:0015816]; L-isoleucine import across plasma membrane [GO:1903806]; L-proline import across plasma membrane [GO:1904271]; proline import across plasma membrane [GO:1905647]; proline transport [GO:0015824]; sodium ion transmembrane transport [GO:0035725]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-proline transmembrane transporter activity [GO:0015193]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; proline:sodium symporter activity [GO:0005298]; solute:sodium symporter activity [GO:0015370]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-proline transmembrane transporter activity [GO:0015193]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; proline:sodium symporter activity [GO:0005298]; solute:sodium symporter activity [GO:0015370]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; amino-acid betaine transport [GO:0015838]; glycine import across plasma membrane [GO:1903804]; glycine transport [GO:0015816]; L-isoleucine import across plasma membrane [GO:1903806]; L-proline import across plasma membrane [GO:1904271]; proline import across plasma membrane [GO:1905647]; proline transport [GO:0015824]; sodium ion transmembrane transport [GO:0035725]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q8VDB9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8VDB9}. Note=Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi. {ECO:0000250|UniProtKB:Q8VDB9}.
Q9NP94	reviewed	S39A2_HUMAN	Zinc transporter ZIP2 (6A1) (Eti-1) (Solute carrier family 39 member 2) (Zrt- and Irt-like protein 2) (ZIP-2) (hZIP2)	SLC39A2 ZIP2	Homo sapiens (Human)	309	FUNCTION: Transporter for the divalent cation Zn(2+) (PubMed:10681536, PubMed:29791142, PubMed:30914478). Mediates the influx of Zn(2+) into cells from extracellular space. The Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential. Transports also other divalent cations Zn(2+), Cd2(+), Cu2(+), Co2(+) in the order of decreasing affinity, respectively (PubMed:29791142, PubMed:30914478). In the skin, aids in the differentiation of keratinocytes in the epidermis (By similarity). {ECO:0000250|UniProtKB:G3X943, ECO:0000269|PubMed:10681536, ECO:0000269|PubMed:29791142, ECO:0000269|PubMed:30914478}.		cadmium ion transmembrane transport [GO:0070574]; keratinocyte differentiation [GO:0030216]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]	metal ion transmembrane transporter activity [GO:0046873]; zinc ion transmembrane transporter activity [GO:0005385]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; metal ion transmembrane transporter activity [GO:0046873]; zinc ion transmembrane transporter activity [GO:0005385]; cadmium ion transmembrane transport [GO:0070574]; keratinocyte differentiation [GO:0030216]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10681536, ECO:0000269|PubMed:30914478}; Multi-pass membrane protein {ECO:0000255}.
Q9NP95	reviewed	FGF20_HUMAN	Fibroblast growth factor 20 (FGF-20)	FGF20	Homo sapiens (Human)	211	FUNCTION: Neurotrophic factor that regulates central nervous development and function. {ECO:0000269|PubMed:16597617}.		animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inner ear auditory receptor cell differentiation [GO:0042491]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dopaminergic neuron differentiation [GO:1904340]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cell migration [GO:0030334]; regulation of dopamine secretion [GO:0014059]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparan sulfate proteoglycan binding [GO:0043395]; receptor-receptor interaction [GO:0090722]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparan sulfate proteoglycan binding [GO:0043395]; receptor-receptor interaction [GO:0090722]; signaling receptor binding [GO:0005102]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inner ear auditory receptor cell differentiation [GO:0042491]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dopaminergic neuron differentiation [GO:1904340]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cell migration [GO:0030334]; regulation of dopamine secretion [GO:0014059]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11306498}.
Q9NP97	reviewed	DLRB1_HUMAN	Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1)	DYNLRB1 BITH DNCL2A DNLC2A ROBLD1 HSPC162	Homo sapiens (Human)	96	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. {ECO:0000305|PubMed:36071160}.	MISCELLANEOUS: [Isoform 2]: May result from the retention of an intron in the cDNA. {ECO:0000305}.	microtubule-based movement [GO:0007018]; visual behavior [GO:0007632]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; dynein complex [GO:0030286]; membrane [GO:0016020]; microtubule [GO:0005874]	dynein intermediate chain binding [GO:0045505]; microtubule motor activity [GO:0003777]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; dynein complex [GO:0030286]; membrane [GO:0016020]; microtubule [GO:0005874]; dynein intermediate chain binding [GO:0045505]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]; visual behavior [GO:0007632]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305|PubMed:36071160}.
Q9NP98	reviewed	MYOZ1_HUMAN	Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ)	MYOZ1 MYOZ	Homo sapiens (Human)	299	FUNCTION: Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.		myofibril assembly [GO:0030239]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of skeletal muscle tissue regeneration [GO:0043417]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sarcomere organization [GO:0045214]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle tissue development [GO:0007519]; wound healing [GO:0042060]	actin cytoskeleton [GO:0015629]; nucleus [GO:0005634]; pseudopodium [GO:0031143]; Z disc [GO:0030018]	actin binding [GO:0003779]; FATZ binding [GO:0051373]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; telethonin binding [GO:0031433]	actin cytoskeleton [GO:0015629]; nucleus [GO:0005634]; pseudopodium [GO:0031143]; Z disc [GO:0030018]; actin binding [GO:0003779]; FATZ binding [GO:0051373]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; telethonin binding [GO:0031433]; myofibril assembly [GO:0030239]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of skeletal muscle tissue regeneration [GO:0043417]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sarcomere organization [GO:0045214]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle tissue development [GO:0007519]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.
Q9NP99	reviewed	TREM1_HUMAN	Triggering receptor expressed on myeloid cells 1 (TREM-1) (Triggering receptor expressed on monocytes 1) (CD antigen CD354)	TREM1	Homo sapiens (Human)	234	FUNCTION: [Isoform 1]: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102). Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:25595774, PubMed:17568691, PubMed:29568119). In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:21659545, PubMed:14656437). This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17568691, PubMed:17098818). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:21393102, PubMed:11323674). {ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:11323674, ECO:0000269|PubMed:14656437, ECO:0000269|PubMed:17098818, ECO:0000269|PubMed:17568691, ECO:0000269|PubMed:21393102, ECO:0000269|PubMed:21659545, ECO:0000269|PubMed:25595774, ECO:0000269|PubMed:29568119}.; FUNCTION: [Isoform 2]: Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its lignad. {ECO:0000269|PubMed:26561551}.		adaptive immune response [GO:0002250]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; neutrophil chemotaxis [GO:0030593]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	receptor decoy activity [GO:0140319]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor decoy activity [GO:0140319]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; neutrophil chemotaxis [GO:0030593]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:17098818, ECO:0000269|PubMed:21393102}; Single-pass type I membrane protein {ECO:0000305}. Note=Recruited to lipid rafts when activated. {ECO:0000269|PubMed:17098818}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:26561551}.
Q9NPA0	reviewed	EMC7_HUMAN	ER membrane protein complex subunit 7	EMC7 C11orf3 C15orf24 HT022 UNQ905/PRO1926	Homo sapiens (Human)	242	FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305}.		protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	carbohydrate binding [GO:0030246]	EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; carbohydrate binding [GO:0030246]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Single-pass type I membrane protein {ECO:0000269|PubMed:32439656}.
Q9NPA1	reviewed	KCMB3_HUMAN	Calcium-activated potassium channel subunit beta-3 (BK channel subunit beta-3) (BKbeta3) (Hbeta3) (Calcium-activated potassium channel, subfamily M subunit beta-3) (Charybdotoxin receptor subunit beta-3) (K(VCA)beta-3) (Maxi K channel subunit beta-3) (Slo-beta-3)	KCNMB3 KCNMB2 KCNMBL	Homo sapiens (Human)	279	FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. {ECO:0000269|PubMed:10766764, ECO:0000269|PubMed:10864947}.		action potential [GO:0001508]; detection of calcium ion [GO:0005513]; neuronal action potential [GO:0019228]; potassium ion transport [GO:0006813]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	calcium-activated potassium channel activity [GO:0015269]; potassium channel regulator activity [GO:0015459]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; calcium-activated potassium channel activity [GO:0015269]; potassium channel regulator activity [GO:0015459]; action potential [GO:0001508]; detection of calcium ion [GO:0005513]; neuronal action potential [GO:0019228]; potassium ion transport [GO:0006813]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NPA2	reviewed	MMP25_HUMAN	Matrix metalloproteinase-25 (MMP-25) (EC 3.4.24.-) (Leukolysin) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (MTMMP6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (MT6MMP)	MMP25 MMP20 MMPL1 MT6MMP	Homo sapiens (Human)	562	FUNCTION: May activate progelatinase A.		collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; hard palate development [GO:0060022]; inflammatory response [GO:0006954]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; hard palate development [GO:0060022]; inflammatory response [GO:0006954]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
Q9NPA8	reviewed	ENY2_HUMAN	Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog)	ENY2 DC6	Homo sapiens (Human)	101	FUNCTION: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820). {ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:21746879, ECO:0000269|PubMed:23591820}.		chromatin organization [GO:0006325]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of DNA-templated transcription [GO:0045893]; protein transport [GO:0015031]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]	DUBm complex [GO:0071819]; mitochondrion [GO:0005739]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]; transcription export complex 2 [GO:0070390]; transcription factor TFTC complex [GO:0033276]	chromatin binding [GO:0003682]; nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713]	DUBm complex [GO:0071819]; mitochondrion [GO:0005739]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]; transcription export complex 2 [GO:0070390]; transcription factor TFTC complex [GO:0033276]; chromatin binding [GO:0003682]; nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713]; chromatin organization [GO:0006325]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of DNA-templated transcription [GO:0045893]; protein transport [GO:0015031]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03046, ECO:0000269|PubMed:22307388}. Note=Localization at the nuclear pore complex requires NUP153 and TPR. {ECO:0000269|PubMed:23591820}.
Q9NPB1	reviewed	NT5M_HUMAN	5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2)	NT5M DNT2	Homo sapiens (Human)	228	FUNCTION: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. {ECO:0000269|PubMed:10899995}.		DNA replication [GO:0006260]; dUMP catabolic process [GO:0046079]; pyrimidine deoxyribonucleotide catabolic process [GO:0009223]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]; nucleotidase activity [GO:0008252]; nucleotide binding [GO:0000166]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]; nucleotidase activity [GO:0008252]; nucleotide binding [GO:0000166]; DNA replication [GO:0006260]; dUMP catabolic process [GO:0046079]; pyrimidine deoxyribonucleotide catabolic process [GO:0009223]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10899995}.
Q9NPB3	reviewed	CABP2_HUMAN	Calcium-binding protein 2 (CaBP2)	CABP2	Homo sapiens (Human)	220	FUNCTION: Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs (PubMed:28183797). Required for the normal transfer of light signals through the retina (By similarity). {ECO:0000250|UniProtKB:Q9JLK4, ECO:0000269|PubMed:28183797}.		sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:19338761}. Cell membrane {ECO:0000269|PubMed:19338761}; Lipid-anchor {ECO:0000269|PubMed:19338761}; Cytoplasmic side {ECO:0000269|PubMed:19338761}. Golgi apparatus {ECO:0000269|PubMed:19338761}.
Q9NPB6	reviewed	PAR6A_HUMAN	Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40)	PARD6A PAR6A	Homo sapiens (Human)	346	FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). {ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:20719959}.		cell division [GO:0051301]; cell-cell junction maintenance [GO:0045217]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of protein secretion [GO:0050714]; regulation of cellular localization [GO:0060341]; viral process [GO:0016032]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; tight junction [GO:0070160]	GTP-dependent protein binding [GO:0030742]; small GTPase binding [GO:0031267]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; tight junction [GO:0070160]; GTP-dependent protein binding [GO:0030742]; small GTPase binding [GO:0031267]; cell division [GO:0051301]; cell-cell junction maintenance [GO:0045217]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of protein secretion [GO:0050714]; regulation of cellular localization [GO:0060341]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:20719959}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20719959}. Note=Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions. Recruited to the centrosome by a microtubule and dynein-dynactin-dependent mechanism. {ECO:0000269|PubMed:20719959}.
Q9NPB9	reviewed	ACKR4_HUMAN	Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR)	ACKR4 CCBP2 CCR11 CCRL1 VSHK1	Homo sapiens (Human)	350	FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus. {ECO:0000269|PubMed:10706668, ECO:0000269|PubMed:23121557, ECO:0000269|PubMed:23341447}.		calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; scavenger receptor activity [GO:0005044]	early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; scavenger receptor activity [GO:0005044]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:23341447}. Recycling endosome {ECO:0000269|PubMed:23341447}. Cell membrane {ECO:0000269|PubMed:23341447}; Multi-pass membrane protein {ECO:0000269|PubMed:23341447}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Q9NPC1	reviewed	LT4R2_HUMAN	Leukotriene B4 receptor 2 (LTB4-R 2) (LTB4-R2) (LTB4 receptor JULF2) (Leukotriene B4 receptor BLT2) (Seven transmembrane receptor BLTR2)	LTB4R2 BLT2R BLTR2	Homo sapiens (Human)	358	FUNCTION: Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.		chemotaxis [GO:0006935]; keratinocyte migration [GO:0051546]; negative regulation of adenylate cyclase activity [GO:0007194]; neuropeptide signaling pathway [GO:0007218]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; leukotriene B4 receptor activity [GO:0001632]; leukotriene receptor activity [GO:0004974]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; leukotriene B4 receptor activity [GO:0001632]; leukotriene receptor activity [GO:0004974]; chemotaxis [GO:0006935]; keratinocyte migration [GO:0051546]; negative regulation of adenylate cyclase activity [GO:0007194]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9NPC2	reviewed	KCNK9_HUMAN	Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) (Two pore potassium channel KT3.2) (Two pore K(+) channel KT3.2)	KCNK9 TASK3	Homo sapiens (Human)	374	FUNCTION: pH-dependent, voltage-insensitive, background potassium channel protein. {ECO:0000269|PubMed:11042359, ECO:0000269|PubMed:11431495, ECO:0000269|PubMed:23169818}.	MISCELLANEOUS: Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0.; MISCELLANEOUS: Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors.	potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; stabilization of membrane potential [GO:0030322]	plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NPC3	reviewed	CIP1_HUMAN	E3 ubiquitin-protein ligase CCNB1IP1 (EC 2.3.2.27) (Cyclin-B1-interacting protein 1) (Human enhancer of invasion 10) (RING-type E3 ubiquitin transferase CCNB1IP1)	CCNB1IP1 C14orf18 HEI10	Homo sapiens (Human)	277	FUNCTION: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. {ECO:0000250, ECO:0000269|PubMed:12612082, ECO:0000269|PubMed:17297447}.; FUNCTION: E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.		blastocyst formation [GO:0001825]; chiasma assembly [GO:0051026]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]	synaptonemal complex [GO:0000795]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	synaptonemal complex [GO:0000795]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; blastocyst formation [GO:0001825]; chiasma assembly [GO:0051026]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Associates to the synaptonemal complex.
Q9NPC4	reviewed	A4GAT_HUMAN	Lactosylceramide 4-alpha-galactosyltransferase (EC 2.4.1.228) (Alpha-1,4-N-acetylglucosaminyltransferase) (Alpha-1,4-galactosyltransferase) (Alpha4Gal-T1) (CD77 synthase) (Globotriaosylceramide synthase) (Gb3 synthase) (P1/Pk synthase) (UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase)	A4GALT A14GALT A4GALT1	Homo sapiens (Human)	353	FUNCTION: Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)) (PubMed:10748143). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143). Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (Probable). Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P (PubMed:10747952). {ECO:0000269|PubMed:10747952, ECO:0000269|PubMed:10748143, ECO:0000305|PubMed:10748143}.; FUNCTION: (Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins. {ECO:0000269|PubMed:10748143}.		globoside biosynthetic process [GO:0001576]; glycosphingolipid biosynthetic process [GO:0006688]; plasma membrane organization [GO:0007009]; protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	acetylglucosaminyltransferase activity [GO:0008375]; galactosyltransferase activity [GO:0008378]; lactosylceramide 4-alpha-galactosyltransferase activity [GO:0050512]; toxic substance binding [GO:0015643]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; acetylglucosaminyltransferase activity [GO:0008375]; galactosyltransferase activity [GO:0008378]; lactosylceramide 4-alpha-galactosyltransferase activity [GO:0050512]; toxic substance binding [GO:0015643]; globoside biosynthetic process [GO:0001576]; glycosphingolipid biosynthetic process [GO:0006688]; plasma membrane organization [GO:0007009]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9NPC6	reviewed	MYOZ2_HUMAN	Myozenin-2 (Calsarcin-1) (FATZ-related protein 2)	MYOZ2 C4orf5	Homo sapiens (Human)	264	FUNCTION: Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.		negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sarcomere organization [GO:0045214]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle tissue development [GO:0007519]	actin cytoskeleton [GO:0015629]; sarcomere [GO:0030017]; Z disc [GO:0030018]	actin binding [GO:0003779]; FATZ binding [GO:0051373]; protein phosphatase 2B binding [GO:0030346]; telethonin binding [GO:0031433]	actin cytoskeleton [GO:0015629]; sarcomere [GO:0030017]; Z disc [GO:0030018]; actin binding [GO:0003779]; FATZ binding [GO:0051373]; protein phosphatase 2B binding [GO:0030346]; telethonin binding [GO:0031433]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sarcomere organization [GO:0045214]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle. {ECO:0000250}.
Q9NPC7	reviewed	MYNN_HUMAN	Myoneurin (Zinc finger and BTB domain-containing protein 31)	MYNN OSZF ZBTB31 SBBIZ1	Homo sapiens (Human)	610			cellular response to leukemia inhibitory factor [GO:1990830]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cellular response to leukemia inhibitory factor [GO:1990830]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14694499}.
Q9NPC8	reviewed	SIX2_HUMAN	Homeobox protein SIX2 (Sine oculis homeobox homolog 2)	SIX2	Homo sapiens (Human)	291	FUNCTION: Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. May also be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration. {ECO:0000250|UniProtKB:Q62232, ECO:0000269|PubMed:22995329}.		anatomical structure morphogenesis [GO:0009653]; anterior/posterior axis specification [GO:0009948]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; condensed mesenchymal cell proliferation [GO:0072137]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; kidney development [GO:0001822]; mesenchymal cell differentiation involved in kidney development [GO:0072161]; mesenchymal stem cell maintenance involved in nephron morphogenesis [GO:0072038]; mesenchymal stem cell proliferation [GO:0097168]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesodermal cell fate specification [GO:0007501]; middle ear morphogenesis [GO:0042474]; negative regulation of epithelial cell differentiation [GO:0030857]; nephron development [GO:0072006]; nephron morphogenesis [GO:0072028]; positive regulation of chondrocyte proliferation [GO:1902732]; protein import into nucleus [GO:0006606]; regulation of branching involved in ureteric bud morphogenesis [GO:0090189]; regulation of chondrocyte differentiation [GO:0032330]; regulation of ossification [GO:0030278]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior axis specification [GO:0009948]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; condensed mesenchymal cell proliferation [GO:0072137]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; kidney development [GO:0001822]; mesenchymal cell differentiation involved in kidney development [GO:0072161]; mesenchymal stem cell maintenance involved in nephron morphogenesis [GO:0072038]; mesenchymal stem cell proliferation [GO:0097168]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesodermal cell fate specification [GO:0007501]; middle ear morphogenesis [GO:0042474]; negative regulation of epithelial cell differentiation [GO:0030857]; nephron development [GO:0072006]; nephron morphogenesis [GO:0072028]; positive regulation of chondrocyte proliferation [GO:1902732]; protein import into nucleus [GO:0006606]; regulation of branching involved in ureteric bud morphogenesis [GO:0090189]; regulation of chondrocyte differentiation [GO:0032330]; regulation of ossification [GO:0030278]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q62232}.
Q9NPD3	reviewed	EXOS4_HUMAN	Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A)	EXOSC4 RRP41 SKI6	Homo sapiens (Human)	245	FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. {ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:21255825}.		defense response to virus [GO:0051607]; DNA deamination [GO:0045006]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; intracellular membrane-bounded organelle [GO:0043231]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5'-RNA exonuclease activity [GO:0000175]; mRNA 3'-UTR AU-rich region binding [GO:0035925]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; intracellular membrane-bounded organelle [GO:0043231]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5'-RNA exonuclease activity [GO:0000175]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; defense response to virus [GO:0051607]; DNA deamination [GO:0045006]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}.
Q9NPD5	reviewed	SO1B3_HUMAN	Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (OATP1B3) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)	SLCO1B3 LST2 OATP1B3 OATP8 SLC21A8	Homo sapiens (Human)	702	FUNCTION: Mediates the Na(+)-independent uptake of organic anions (PubMed:15159445, PubMed:17412826, PubMed:10779507). Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate), as well as eicosanoid leukotriene C4, prostaglandin E2 and L-thyroxine (T4) (PubMed:15159445, PubMed:17412826, PubMed:10779507, PubMed:12568656, PubMed:11159893, PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). Shows a pH-sensitive substrate specificity towards sulfated steroids, taurocholate and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Involved in the clearance of bile acids and organic anions from the liver (PubMed:22232210). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop (PubMed:22232210). Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition (PubMed:26383540). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins) such as pitavastatin, a clinically important class of hypolipidemic drugs (PubMed:15159445). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220). May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver (PubMed:16627748, PubMed:16624871). {ECO:0000269|PubMed:10779507, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:12568656, ECO:0000269|PubMed:15159445, ECO:0000269|PubMed:16624871, ECO:0000269|PubMed:16627748, ECO:0000269|PubMed:17412826, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:22232210, ECO:0000269|PubMed:23243220, ECO:0000269|PubMed:26383540, ECO:0000305|PubMed:35307651}.		bile acid and bile salt transport [GO:0015721]; heme catabolic process [GO:0042167]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; xenobiotic metabolic process [GO:0006805]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; serine-type endopeptidase inhibitor activity [GO:0004867]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; serine-type endopeptidase inhibitor activity [GO:0004867]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; bile acid and bile salt transport [GO:0015721]; heme catabolic process [GO:0042167]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:10779507}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basolateral membrane of hepatocytes (PubMed:10779507). Localized to the basal membrane of Sertoli cells (PubMed:35307651). {ECO:0000269|PubMed:10779507, ECO:0000269|PubMed:35307651}.
Q9NPD8	reviewed	UBE2T_HUMAN	Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (Cell proliferation-inducing gene 50 protein) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T)	UBE2T HSPC150 PIG50	Homo sapiens (Human)	197	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386). {ECO:0000269|PubMed:16916645, ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:19887602, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:28437106}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; chromatin binding [GO:0003682]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19887602}. Note=Accumulates to chromatin.
Q9NPE2	reviewed	NGRN_HUMAN	Neugrin (Mesenchymal stem cell protein DSC92) (Neurite outgrowth-associated protein) (Spinal cord-derived protein FI58G)	NGRN FI58G HT020	Homo sapiens (Human)	291	FUNCTION: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. {ECO:0000269|PubMed:27667664}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mitochondrial ribosome assembly [GO:0061668]; neuron differentiation [GO:0030182]; positive regulation of mitochondrial translation [GO:0070131]	extracellular region [GO:0005576]; intercellular bridge [GO:0045171]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]	extracellular region [GO:0005576]; intercellular bridge [GO:0045171]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; mitochondrial ribosome assembly [GO:0061668]; neuron differentiation [GO:0030182]; positive regulation of mitochondrial translation [GO:0070131]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11118320}. Secreted {ECO:0000305}. Mitochondrion membrane {ECO:0000269|PubMed:27667664}.
Q9NPE3	reviewed	NOP10_HUMAN	H/ACA ribonucleoprotein complex subunit 3 (Nucleolar protein 10) (Nucleolar protein family A member 3) (snoRNP protein NOP10)	NOP10 NOLA3	Homo sapiens (Human)	64	FUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:15044956}.		positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; pseudouridine synthesis [GO:0001522]; rRNA pseudouridine synthesis [GO:0031118]; snRNA pseudouridine synthesis [GO:0031120]; telomere maintenance via telomerase [GO:0007004]	box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; telomerase holoenzyme complex [GO:0005697]	box H/ACA snoRNA binding [GO:0034513]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; telomerase holoenzyme complex [GO:0005697]; box H/ACA snoRNA binding [GO:0034513]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; pseudouridine synthesis [GO:0001522]; rRNA pseudouridine synthesis [GO:0031118]; snRNA pseudouridine synthesis [GO:0031120]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11074001}. Nucleus, Cajal body {ECO:0000269|PubMed:11074001}. Note=Also localized to Cajal bodies (coiled bodies).
Q9NPE6	reviewed	SPAG4_HUMAN	Sperm-associated antigen 4 protein (Outer dense fiber-associated protein SPAG4) (SUN domain-containing protein 4)	SPAG4 SUN4	Homo sapiens (Human)	437	FUNCTION: Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail. {ECO:0000250|UniProtKB:O55034, ECO:0000250|UniProtKB:Q9JJF2}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; motile cilium [GO:0031514]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]	protein-membrane adaptor activity [GO:0043495]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; motile cilium [GO:0031514]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; protein-membrane adaptor activity [GO:0043495]; structural molecule activity [GO:0005198]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O55034}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:O55034}. Nucleus envelope {ECO:0000250|UniProtKB:Q9JJF2}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q9JJF2}. Note=In spermatids, it is localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm (By similarity). Colocalized with SEPT12 at the nuclear periphery in round spermatids, at sperm neck in elongated spermatids and at midpiece regions in ejaculated spermatozoa (PubMed:25775403). {ECO:0000250|UniProtKB:O55034, ECO:0000269|PubMed:25775403}.
Q9NPF0	reviewed	CD320_HUMAN	CD320 antigen (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6) (Transcobalamin receptor) (TCblR) (CD antigen CD320)	CD320 8D6A UNQ198/PRO224	Homo sapiens (Human)	282	FUNCTION: Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631). {ECO:0000269|PubMed:10727470, ECO:0000269|PubMed:11418631, ECO:0000269|PubMed:18779389, ECO:0000269|PubMed:20524213}.		B cell costimulation [GO:0031296]; cobalamin transport [GO:0015889]; positive regulation of B cell proliferation [GO:0030890]; regulation of vitamin metabolic process [GO:0030656]; ventral spinal cord development [GO:0021517]	caveola [GO:0005901]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; cobalamin binding [GO:0031419]; growth factor activity [GO:0008083]	caveola [GO:0005901]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; cobalamin binding [GO:0031419]; growth factor activity [GO:0008083]; B cell costimulation [GO:0031296]; cobalamin transport [GO:0015889]; positive regulation of B cell proliferation [GO:0030890]; regulation of vitamin metabolic process [GO:0030656]; ventral spinal cord development [GO:0021517]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10727470, ECO:0000269|PubMed:11418631, ECO:0000305|PubMed:18779389}; Single-pass type I membrane protein {ECO:0000305}.
Q9NPF2	reviewed	CHSTB_HUMAN	Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4S-1) (C4ST-1) (C4ST1)	CHST11	Homo sapiens (Human)	352	FUNCTION: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.		apoptotic process [GO:0006915]; carbohydrate biosynthetic process [GO:0016051]; chondrocyte development [GO:0002063]; chondroitin sulfate biosynthetic process [GO:0030206]; developmental growth [GO:0048589]; embryonic digit morphogenesis [GO:0042733]; embryonic viscerocranium morphogenesis [GO:0048703]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; polysaccharide localization [GO:0033037]; post-anal tail morphogenesis [GO:0036342]; post-embryonic development [GO:0009791]; proteoglycan biosynthetic process [GO:0030166]; regulation of cell population proliferation [GO:0042127]; respiratory gaseous exchange by respiratory system [GO:0007585]; transforming growth factor beta receptor signaling pathway [GO:0007179]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	chondroitin 4-sulfotransferase activity [GO:0047756]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity [GO:0050659]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; chondroitin 4-sulfotransferase activity [GO:0047756]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity [GO:0050659]; sulfotransferase activity [GO:0008146]; apoptotic process [GO:0006915]; carbohydrate biosynthetic process [GO:0016051]; chondrocyte development [GO:0002063]; chondroitin sulfate biosynthetic process [GO:0030206]; developmental growth [GO:0048589]; embryonic digit morphogenesis [GO:0042733]; embryonic viscerocranium morphogenesis [GO:0048703]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; polysaccharide localization [GO:0033037]; post-anal tail morphogenesis [GO:0036342]; post-embryonic development [GO:0009791]; proteoglycan biosynthetic process [GO:0030166]; regulation of cell population proliferation [GO:0042127]; respiratory gaseous exchange by respiratory system [GO:0007585]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9NPF4	reviewed	OSGEP_HUMAN	tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP)	OSGEP GCPL1	Homo sapiens (Human)	335	FUNCTION: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. {ECO:0000255|HAMAP-Rule:MF_03180, ECO:0000269|PubMed:28272532, ECO:0000269|PubMed:28805828, ECO:0000305|PubMed:22912744, ECO:0000305|PubMed:27903914}.		tRNA modification [GO:0006400]; tRNA threonylcarbamoyladenosine modification [GO:0002949]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	catalytic activity, acting on a tRNA [GO:0140101]; metal ion binding [GO:0046872]; N(6)-L-threonylcarbamoyladenine synthase activity [GO:0061711]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; catalytic activity, acting on a tRNA [GO:0140101]; metal ion binding [GO:0046872]; N(6)-L-threonylcarbamoyladenine synthase activity [GO:0061711]; tRNA modification [GO:0006400]; tRNA threonylcarbamoyladenosine modification [GO:0002949]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03180, ECO:0000269|PubMed:28805828}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03180, ECO:0000269|PubMed:22912744, ECO:0000269|PubMed:28805828}.
Q9NPF5	reviewed	DMAP1_HUMAN	DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1)	DMAP1 KIAA1425	Homo sapiens (Human)	467	FUNCTION: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269|PubMed:14665632, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:14978102, ECO:0000269|PubMed:15367675}.		chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein import into nucleus [GO:0042307]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; response to ethanol [GO:0045471]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; replication fork [GO:0005657]; Swr1 complex [GO:0000812]	RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; replication fork [GO:0005657]; Swr1 complex [GO:0000812]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein import into nucleus [GO:0042307]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; response to ethanol [GO:0045471]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1.
Q9NPF7	reviewed	IL23A_HUMAN	Interleukin-23 subunit alpha (IL-23 subunit alpha) (IL-23-A) (Interleukin-23 subunit p19) (IL-23p19)	IL23A SGRF UNQ2498/PRO5798	Homo sapiens (Human)	189	FUNCTION: Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383). Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (PubMed:32474165, PubMed:29287995, PubMed:33606986). This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A (PubMed:12023369). In turn, participates in the early and effective intracellular bacterial clearance (PubMed:32474165). Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:17676044). {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:16424222, ECO:0000269|PubMed:17676044, ECO:0000269|PubMed:29287995, ECO:0000269|PubMed:32474165, ECO:0000269|PubMed:33606986}.		defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of interleukin-10 production [GO:0032693]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]; T cell proliferation [GO:0042098]; tissue remodeling [GO:0048771]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; interleukin-23 complex [GO:0070743]	cytokine activity [GO:0005125]; interleukin-23 receptor binding [GO:0045519]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; interleukin-23 complex [GO:0070743]; cytokine activity [GO:0005125]; interleukin-23 receptor binding [GO:0045519]; defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of interleukin-10 production [GO:0032693]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of activation of Janus kinase activity [GO:0010536]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]; T cell proliferation [GO:0042098]; tissue remodeling [GO:0048771]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B.
Q9NPF8	reviewed	ADAP2_HUMAN	Arf-GAP with dual PH domain-containing protein 2 (Centaurin-alpha-2) (Cnt-a2)	ADAP2 CENTA2	Homo sapiens (Human)	381	FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. {ECO:0000269|PubMed:14690521, ECO:0000305}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site. {ECO:0000305}.	heart development [GO:0007507]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial envelope [GO:0005740]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-macromolecule adaptor activity [GO:0030674]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial envelope [GO:0005740]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-macromolecule adaptor activity [GO:0030674]; heart development [GO:0007507]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14690521}. Cell membrane {ECO:0000269|PubMed:14690521}. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus.
Q9NPG1	reviewed	FZD3_HUMAN	Frizzled-3 (Fz-3) (hFz3)	FZD3	Homo sapiens (Human)	666	FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q61086}.		canonical Wnt signaling pathway [GO:0060070]; cell proliferation in midbrain [GO:0033278]; commissural neuron axon guidance [GO:0071679]; dopaminergic neuron axon guidance [GO:0036514]; establishment of planar polarity [GO:0001736]; hair follicle development [GO:0001942]; inner ear morphogenesis [GO:0042472]; midbrain morphogenesis [GO:1904693]; motor neuron migration [GO:0097475]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of mitotic cell cycle, embryonic [GO:0045976]; neural tube closure [GO:0001843]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; planar cell polarity pathway involved in axon guidance [GO:1904938]; positive regulation of neuroblast proliferation [GO:0002052]; post-anal tail morphogenesis [GO:0036342]; response to electrical stimulus [GO:0051602]; response to xenobiotic stimulus [GO:0009410]; serotonergic neuron axon guidance [GO:0036515]; sympathetic ganglion development [GO:0061549]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; filopodium tip [GO:0032433]; lateral plasma membrane [GO:0016328]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]	G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; filopodium tip [GO:0032433]; lateral plasma membrane [GO:0016328]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; canonical Wnt signaling pathway [GO:0060070]; cell proliferation in midbrain [GO:0033278]; commissural neuron axon guidance [GO:0071679]; dopaminergic neuron axon guidance [GO:0036514]; establishment of planar polarity [GO:0001736]; hair follicle development [GO:0001942]; inner ear morphogenesis [GO:0042472]; midbrain morphogenesis [GO:1904693]; motor neuron migration [GO:0097475]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of mitotic cell cycle, embryonic [GO:0045976]; neural tube closure [GO:0001843]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; planar cell polarity pathway involved in axon guidance [GO:1904938]; positive regulation of neuroblast proliferation [GO:0002052]; post-anal tail morphogenesis [GO:0036342]; response to electrical stimulus [GO:0051602]; response to xenobiotic stimulus [GO:0009410]; serotonergic neuron axon guidance [GO:0036515]; sympathetic ganglion development [GO:0061549]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:Q61086}. Apical cell membrane {ECO:0000250|UniProtKB:Q61086}; Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell (By similarity). {ECO:0000250|UniProtKB:Q61086}.
Q9NPG2	reviewed	NGB_HUMAN	Neuroglobin	NGB	Homo sapiens (Human)	151	FUNCTION: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. {ECO:0000269|PubMed:11029004, ECO:0000269|PubMed:11473128, ECO:0000269|PubMed:18416560, ECO:0000269|PubMed:21190290, ECO:0000269|PubMed:21296891}.		apoptotic process [GO:0006915]; oxygen transport [GO:0015671]; response to hypoxia [GO:0001666]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; perikaryon [GO:0043204]	heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; perikaryon [GO:0043204]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; apoptotic process [GO:0006915]; oxygen transport [GO:0015671]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Perikaryon {ECO:0000250}. Cytoplasm. Mitochondrion.
Q9NPG3	reviewed	UBN1_HUMAN	Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein)	UBN1	Homo sapiens (Human)	1134	FUNCTION: Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}.		nucleosome assembly [GO:0006334]	bicellular tight junction [GO:0005923]; centriolar satellite [GO:0034451]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	DNA binding [GO:0003677]	bicellular tight junction [GO:0005923]; centriolar satellite [GO:0034451]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; DNA binding [GO:0003677]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.
Q9NPG4	reviewed	PCD12_HUMAN	Protocadherin-12 (Vascular cadherin-2) (Vascular endothelial cadherin-2) (VE-cad-2) (VE-cadherin-2) [Cleaved into: Protocadherin-12, secreted form]	PCDH12 UNQ395/PRO731	Homo sapiens (Human)	1184	FUNCTION: Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). {ECO:0000250|UniProtKB:O55134, ECO:0000269|PubMed:21402705}.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; glycogen metabolic process [GO:0005977]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; labyrinthine layer development [GO:0060711]; neuron recognition [GO:0008038]	cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; glycogen metabolic process [GO:0005977]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; labyrinthine layer development [GO:0060711]; neuron recognition [GO:0008038]	SUBCELLULAR LOCATION: [Protocadherin-12]: Cell membrane {ECO:0000269|PubMed:21402705}; Single-pass type I membrane protein {ECO:0000255}. Cell junction {ECO:0000250|UniProtKB:O55134}.; SUBCELLULAR LOCATION: [Protocadherin-12, secreted form]: Secreted {ECO:0000269|PubMed:21402705}. Note=The secreted form is produced following cleavage by ADAM10. {ECO:0000269|PubMed:21402705}.
Q9NPG8	reviewed	ZDHC4_HUMAN	Palmitoyltransferase ZDHHC4 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 4) (DHHC-4) (Zinc finger protein 374)	ZDHHC4 ZNF374 DC1 UNQ5787/PRO19576	Homo sapiens (Human)	344	FUNCTION: Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates including the D(2) dopamine receptor DRD2. {ECO:0000269|PubMed:26535572}.		protein targeting to membrane [GO:0006612]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21926431}; Multi-pass membrane protein {ECO:0000305|PubMed:21926431}. Golgi apparatus membrane {ECO:0000269|PubMed:26535572}; Multi-pass membrane protein {ECO:0000305|PubMed:21926431}. Cell membrane {ECO:0000269|PubMed:26535572}; Multi-pass membrane protein {ECO:0000255}.
Q9NPH0	reviewed	PPA6_HUMAN	Lysophosphatidic acid phosphatase type 6 (EC 3.1.3.2) (Acid phosphatase 6, lysophosphatidic) (Acid phosphatase-like protein 1) (PACPL1)	ACP6 ACPL1 LPAP UNQ205/PRO231	Homo sapiens (Human)	428	FUNCTION: Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. {ECO:0000269|PubMed:10506173, ECO:0000269|PubMed:23807634}.		dephosphorylation [GO:0016311]; hematopoietic progenitor cell differentiation [GO:0002244]; lysobisphosphatidic acid metabolic process [GO:2001311]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid metabolic process [GO:0006644]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	acid phosphatase activity [GO:0003993]; lysophosphatidic acid phosphatase activity [GO:0052642]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; acid phosphatase activity [GO:0003993]; lysophosphatidic acid phosphatase activity [GO:0052642]; dephosphorylation [GO:0016311]; hematopoietic progenitor cell differentiation [GO:0002244]; lysobisphosphatidic acid metabolic process [GO:2001311]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid metabolic process [GO:0006644]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10506173}.
Q9NPH2	reviewed	INO1_HUMAN	Inositol-3-phosphate synthase 1 (IPS 1) (EC 5.5.1.4) (Myo-inositol 1-phosphate synthase) (MI-1-P synthase) (MIP synthase) (hIPS) (Myo-inositol 1-phosphate synthase A1) (hINO1)	ISYNA1 INO1	Homo sapiens (Human)	558	FUNCTION: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:15024000, PubMed:23902760). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (PubMed:15024000). {ECO:0000269|PubMed:15024000, ECO:0000269|PubMed:23902760}.		inositol biosynthetic process [GO:0006021]; phospholipid biosynthetic process [GO:0008654]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	inositol-3-phosphate synthase activity [GO:0004512]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; inositol-3-phosphate synthase activity [GO:0004512]; inositol biosynthetic process [GO:0006021]; phospholipid biosynthetic process [GO:0008654]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P11986}.
Q9NPH3	reviewed	IL1AP_HUMAN	Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)	IL1RAP C3orf13 IL1R3	Homo sapiens (Human)	570	FUNCTION: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:10799889, ECO:0000269|PubMed:9371760, ECO:0000305|PubMed:10653850, ECO:0000305|PubMed:19836339}.; FUNCTION: [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:12530978}.; FUNCTION: [Isoform 4]: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:19481478}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of synapse assembly [GO:0051965]; protein-containing complex assembly [GO:0065003]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling by trans-synaptic complex [GO:0099545]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]	coreceptor activity [GO:0015026]; interleukin-1 receptor activity [GO:0004908]; interleukin-1 receptor binding [GO:0005149]; interleukin-33 receptor activity [GO:0002114]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; coreceptor activity [GO:0015026]; interleukin-1 receptor activity [GO:0004908]; interleukin-1 receptor binding [GO:0005149]; interleukin-33 receptor activity [GO:0002114]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of synapse assembly [GO:0051965]; protein-containing complex assembly [GO:0065003]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling by trans-synaptic complex [GO:0099545]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Q9NPH5	reviewed	NOX4_HUMAN	NADPH oxidase 4 (EC 1.6.3.-) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Renal NAD(P)H-oxidase)	NOX4 RENOX	Homo sapiens (Human)	578	FUNCTION: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.; FUNCTION: [Isoform 4]: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.		bone resorption [GO:0045453]; cardiac muscle cell differentiation [GO:0055007]; cell morphogenesis [GO:0000902]; cellular response to glucose stimulus [GO:0071333]; defense response [GO:0006952]; gene expression [GO:0010467]; heart process [GO:0003015]; homocysteine metabolic process [GO:0050667]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein tyrosine kinase activity [GO:0061098]; reactive oxygen species biosynthetic process [GO:1903409]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrion [GO:0005739]; NADPH oxidase complex [GO:0043020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; modified amino acid binding [GO:0072341]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; nucleotide binding [GO:0000166]; oxygen sensor activity [GO:0019826]; protein tyrosine kinase binding [GO:1990782]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]	endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrion [GO:0005739]; NADPH oxidase complex [GO:0043020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; modified amino acid binding [GO:0072341]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; nucleotide binding [GO:0000166]; oxygen sensor activity [GO:0019826]; protein tyrosine kinase binding [GO:1990782]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; bone resorption [GO:0045453]; cardiac muscle cell differentiation [GO:0055007]; cell morphogenesis [GO:0000902]; cellular response to glucose stimulus [GO:0071333]; defense response [GO:0006952]; gene expression [GO:0010467]; heart process [GO:0003015]; homocysteine metabolic process [GO:0050667]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein tyrosine kinase activity [GO:0061098]; reactive oxygen species biosynthetic process [GO:1903409]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26742780}; Multi-pass membrane protein. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, focal adhesion {ECO:0000305}. Note=May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000269|PubMed:23393389}. Nucleus, nucleolus {ECO:0000269|PubMed:23393389}.
Q9NPH9	reviewed	IL26_HUMAN	Interleukin-26 (IL-26) (Protein AK155)	IL26 AK155	Homo sapiens (Human)	171	FUNCTION: May play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. {ECO:0000269|PubMed:14764663, ECO:0000269|PubMed:15178681, ECO:0000269|PubMed:18483078}.		cell-cell signaling [GO:0007267]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; cell-cell signaling [GO:0007267]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18483078}.
Q9NPI0	reviewed	TM138_HUMAN	Transmembrane protein 138	TMEM138 HSPC196 HSPC198	Homo sapiens (Human)	162	FUNCTION: Required for ciliogenesis. {ECO:0000269|PubMed:22282472}.	MISCELLANEOUS: TMEM138 and TMEM216 genes are adjacent and are aligned in a head-to-tail configuration. They share some cis regulatory region and display coordinated expression. Genes were joined by chromosomal rearrangement at the amphiboan to reptile evolutionary transition around 340 million years ago (PubMed:22282472). {ECO:0000305|PubMed:22282472}.	cilium assembly [GO:0060271]	cilium [GO:0005929]; vacuolar membrane [GO:0005774]		cilium [GO:0005929]; vacuolar membrane [GO:0005774]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:22282472}; Multi-pass membrane protein {ECO:0000269|PubMed:22282472}. Cell projection, cilium {ECO:0000269|PubMed:22282472}. Note=Localizes to vesicles en route to the base of cilium.
Q9NPI1	reviewed	BRD7_HUMAN	Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1)	BRD7 BP75 CELTIX1	Homo sapiens (Human)	651	FUNCTION: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}.		cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]	histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; p53 binding [GO:0002039]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; p53 binding [GO:0002039]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:25593309}. Chromosome {ECO:0000269|PubMed:16265664}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:11025449}.
Q9NPI5	reviewed	NRK2_HUMAN	Nicotinamide riboside kinase 2 (NRK 2) (NmR-K 2) (EC 2.7.1.22) (Integrin beta-1-binding protein 3) (Muscle integrin-binding protein) (MIBP) (Nicotinic acid riboside kinase 2) (EC 2.7.1.173) (Ribosylnicotinamide kinase 2) (RNK 2) (Ribosylnicotinic acid kinase 2)	NMRK2 ITGB1BP3 NRK2	Homo sapiens (Human)	230	FUNCTION: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis. {ECO:0000269|PubMed:10613898, ECO:0000269|PubMed:15137942}.		NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674]; negative regulation of myoblast differentiation [GO:0045662]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; ribosylnicotinamide kinase activity [GO:0050262]; ribosylnicotinate kinase activity [GO:0061769]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; ribosylnicotinamide kinase activity [GO:0050262]; ribosylnicotinate kinase activity [GO:0061769]; NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674]; negative regulation of myoblast differentiation [GO:0045662]; phosphorylation [GO:0016310]	
Q9NPI6	reviewed	DCP1A_HUMAN	mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF)	DCP1A SMIF	Homo sapiens (Human)	582	FUNCTION: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}.		deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; methylguanosine-cap decapping [GO:0110156]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein localization to cytoplasmic stress granule [GO:1903608]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; mRNA binding [GO:0003729]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; methylguanosine-cap decapping [GO:0110156]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein localization to cytoplasmic stress granule [GO:1903608]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12515382, ECO:0000269|PubMed:16364915}. Nucleus {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715}. Note=Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524). {ECO:0000250|UniProtKB:Q91YD3, ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:16364915}.
Q9NPI8	reviewed	FANCF_HUMAN	Fanconi anemia group F protein (Protein FACF)	FANCF	Homo sapiens (Human)	374	FUNCTION: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity). {ECO:0000250}.		DNA damage response [GO:0006974]; interstrand cross-link repair [GO:0036297]	chromatin [GO:0000785]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]		chromatin [GO:0000785]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; DNA damage response [GO:0006974]; interstrand cross-link repair [GO:0036297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11063725, ECO:0000269|PubMed:18550849}.
Q9NPI9	reviewed	KCJ16_HUMAN	Inward rectifier potassium channel 16 (Inward rectifier K(+) channel Kir5.1) (Potassium channel, inwardly rectifying subfamily J member 16)	KCNJ16	Homo sapiens (Human)	418	FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201). {ECO:0000305|PubMed:24561201}.		potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	inward rectifier potassium channel activity [GO:0005242]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; inward rectifier potassium channel activity [GO:0005242]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24561201}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:24561201}. Note=In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10. {ECO:0000269|PubMed:24561201}.
Q9NPJ1	reviewed	MKKS_HUMAN	Molecular chaperone MKKS (Bardet-Biedl syndrome 6 protein) (McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin)	MKKS BBS6	Homo sapiens (Human)	570	FUNCTION: Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (PubMed:20080638). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis (PubMed:28753627). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:28753627}.		artery smooth muscle contraction [GO:0014824]; brain morphogenesis [GO:0048854]; cartilage development [GO:0051216]; cerebral cortex development [GO:0021987]; chaperone-mediated protein complex assembly [GO:0051131]; cilium assembly [GO:0060271]; convergent extension involved in gastrulation [GO:0060027]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; determination of left/right symmetry [GO:0007368]; developmental process [GO:0032502]; face development [GO:0060324]; fat cell differentiation [GO:0045444]; gonad development [GO:0008406]; heart development [GO:0007507]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; intracellular transport [GO:0046907]; melanosome transport [GO:0032402]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of blood pressure [GO:0045776]; negative regulation of gene expression [GO:0010629]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; pigment granule aggregation in cell center [GO:0051877]; positive regulation of multicellular organism growth [GO:0040018]; protein folding [GO:0006457]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of stress fiber assembly [GO:0051492]; sensory perception of smell [GO:0007608]; social behavior [GO:0035176]; spermatid development [GO:0007286]; striatum development [GO:0021756]; vasodilation [GO:0042311]; visual perception [GO:0007601]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinociliary basal body [GO:1902636]; motile cilium [GO:0031514]; nucleus [GO:0005634]	ATP binding [GO:0005524]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; unfolded protein binding [GO:0051082]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinociliary basal body [GO:1902636]; motile cilium [GO:0031514]; nucleus [GO:0005634]; ATP binding [GO:0005524]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; unfolded protein binding [GO:0051082]; artery smooth muscle contraction [GO:0014824]; brain morphogenesis [GO:0048854]; cartilage development [GO:0051216]; cerebral cortex development [GO:0021987]; chaperone-mediated protein complex assembly [GO:0051131]; cilium assembly [GO:0060271]; convergent extension involved in gastrulation [GO:0060027]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; determination of left/right symmetry [GO:0007368]; developmental process [GO:0032502]; face development [GO:0060324]; fat cell differentiation [GO:0045444]; gonad development [GO:0008406]; heart development [GO:0007507]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; intracellular transport [GO:0046907]; melanosome transport [GO:0032402]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of blood pressure [GO:0045776]; negative regulation of gene expression [GO:0010629]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; pigment granule aggregation in cell center [GO:0051877]; positive regulation of multicellular organism growth [GO:0040018]; protein folding [GO:0006457]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of stress fiber assembly [GO:0051492]; sensory perception of smell [GO:0007608]; social behavior [GO:0035176]; spermatid development [GO:0007286]; striatum development [GO:0021756]; vasodilation [GO:0042311]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol {ECO:0000269|PubMed:28753627}. Nucleus {ECO:0000269|PubMed:28753627}. Note=The majority of the protein resides within the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, the protein is confined to the lateral surfaces of the PCM but during mitosis it relocalizes throughout the PCM and is found at the intercellular bridge. The MKSS protein is highly mobile and rapidly shuttles between the cytosol and centrosome.
Q9NPJ3	reviewed	ACO13_HUMAN	Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Thioesterase superfamily member 2) (THEM2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed]	ACOT13 THEM2 HT012 PNAS-27	Homo sapiens (Human)	140	FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16934754, PubMed:19170545). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity) (PubMed:16934754, PubMed:19170545). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity) (PubMed:16934754, PubMed:19170545). May play a role in controlling adaptive thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CQR4, ECO:0000269|PubMed:16934754, ECO:0000269|PubMed:19170545}.		lipid metabolic process [GO:0006629]; negative regulation of cold-induced thermogenesis [GO:0120163]; protein homotetramerization [GO:0051289]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; spindle [GO:0005819]	acyl-CoA hydrolase activity [GO:0047617]; metal ion binding [GO:0046872]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; spindle [GO:0005819]; acyl-CoA hydrolase activity [GO:0047617]; metal ion binding [GO:0046872]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; lipid metabolic process [GO:0006629]; negative regulation of cold-induced thermogenesis [GO:0120163]; protein homotetramerization [GO:0051289]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9CQR4}. Mitochondrion {ECO:0000250|UniProtKB:Q9CQR4}. Nucleus {ECO:0000250|UniProtKB:Q9CQR4}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9CQR4}. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin. {ECO:0000250|UniProtKB:Q9CQR4}.
Q9NPJ4	reviewed	PNRC2_HUMAN	Proline-rich nuclear receptor coactivator 2	PNRC2 HSPC208	Homo sapiens (Human)	139	FUNCTION: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity). {ECO:0000250|UniProtKB:Q9CR73, ECO:0000269|PubMed:11574675, ECO:0000269|PubMed:19150429, ECO:0000269|PubMed:25775514}.		deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]		cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19150429}. Cytoplasm, P-body {ECO:0000269|PubMed:19150429}.
Q9NPJ6	reviewed	MED4_HUMAN	Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)	MED4 ARC36 DRIP36 VDRIP HSPC126	Homo sapiens (Human)	270	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.		positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
Q9NPJ8	reviewed	NXT2_HUMAN	NTF2-related export protein 2 (Protein p15-2)	NXT2 BM-025 DC9	Homo sapiens (Human)	142	FUNCTION: Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.		mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]	cytosol [GO:0005829]; nuclear pore central transport channel [GO:0044613]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]		cytosol [GO:0005829]; nuclear pore central transport channel [GO:0044613]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Q9NPL8	reviewed	TIDC1_HUMAN	Complex I assembly factor TIMMDC1, mitochondrial (Protein M5-14) (Translocase of inner mitochondrial membrane domain-containing protein 1) (TIMM domain containing-protein 1)	TIMMDC1 C3orf1 UNQ247/PRO284	Homo sapiens (Human)	285	FUNCTION: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I. {ECO:0000269|PubMed:24191001}.			mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:24191001}; Multi-pass membrane protein {ECO:0000269|PubMed:24191001}.
Q9NPP4	reviewed	NLRC4_HUMAN	NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (CED-4-like protein Clan) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)	NLRC4 CARD12 CLAN CLAN1 IPAF UNQ6189/PRO20215	Homo sapiens (Human)	1024	FUNCTION: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity). {ECO:0000250|UniProtKB:Q3UP24, ECO:0000269|PubMed:15107016}.		activation of cysteine-type endopeptidase activity [GO:0097202]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; icosanoid biosynthetic process [GO:0046456]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein processing [GO:0010954]; protein homooligomerization [GO:0051260]; pyroptosis [GO:0070269]	canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; IPAF inflammasome complex [GO:0072557]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; caspase binding [GO:0089720]; endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]	canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; IPAF inflammasome complex [GO:0072557]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; caspase binding [GO:0089720]; endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; activation of cysteine-type endopeptidase activity [GO:0097202]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; icosanoid biosynthetic process [GO:0046456]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein processing [GO:0010954]; protein homooligomerization [GO:0051260]; pyroptosis [GO:0070269]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11390368}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q3UP24}. Inflammasome {ECO:0000269|PubMed:15107016, ECO:0000269|PubMed:33420028}.
Q9NPQ8	reviewed	RIC8A_HUMAN	Synembryn-A (Protein Ric-8A)	RIC8A	Homo sapiens (Human)	531	FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. {ECO:0000250, ECO:0000269|PubMed:16629901}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; basement membrane organization [GO:0071711]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion involved in gastrulation [GO:0070586]; G protein-coupled receptor signaling pathway [GO:0007186]; in utero embryonic development [GO:0001701]; vasculature development [GO:0001944]; visual learning [GO:0008542]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; basement membrane organization [GO:0071711]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion involved in gastrulation [GO:0070586]; G protein-coupled receptor signaling pathway [GO:0007186]; in utero embryonic development [GO:0001701]; vasculature development [GO:0001944]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q80ZG1}. Cell membrane {ECO:0000250|UniProtKB:Q80ZG1}. Note=Colocalizes with RGS14 in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). {ECO:0000250}.
Q9NPR2	reviewed	SEM4B_HUMAN	Semaphorin-4B (Semaphorin-C)	SEMA4B KIAA1745 SEMAC UNQ749/PRO1480	Homo sapiens (Human)	837	FUNCTION: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. {ECO:0000250}.		axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9NPR9	reviewed	GP108_HUMAN	Protein GPR108 (Lung seven transmembrane receptor 2)	GPR108 LUSTR2	Homo sapiens (Human)	543	FUNCTION: May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response. {ECO:0000250|UniProtKB:Q91WD0}.; FUNCTION: (Microbial infection) Plays an essential function in adeno-associated virus (AAV) transduction across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus. {ECO:0000269|PubMed:31784416, ECO:0000269|PubMed:32280726}.		negative regulation of toll-like receptor signaling pathway [GO:0034122]; regulation of immune response [GO:0050776]	cis-Golgi network membrane [GO:0033106]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]		cis-Golgi network membrane [GO:0033106]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q91WD0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91WD0}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:31784416}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91WD0}. Golgi apparatus membrane {ECO:0000269|PubMed:32280726}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with TLR3, -7, -4, and -9. {ECO:0000250|UniProtKB:Q91WD0}.
Q9NPY3	reviewed	C1QR1_HUMAN	Complement component C1q receptor (C1q/MBL/SPA receptor) (C1qR) (C1qR(p)) (C1qRp) (CDw93) (Complement component 1 q subcomponent receptor 1) (Matrix-remodeling-associated protein 4) (CD antigen CD93)	CD93 C1QR1 MXRA4	Homo sapiens (Human)	652	FUNCTION: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.		cell-cell adhesion [GO:0098609]; macrophage activation [GO:0042116]; phagocytosis [GO:0006909]	cell surface [GO:0009986]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; complement component C1q complex binding [GO:0001849]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; complement component C1q complex binding [GO:0001849]; signaling receptor activity [GO:0038023]; cell-cell adhesion [GO:0098609]; macrophage activation [GO:0042116]; phagocytosis [GO:0006909]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9NPZ5	reviewed	B3GA2_HUMAN	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 2) (GlcAT-D) (UDP-glucuronosyltransferase S) (GlcAT-S) (Glucuronosyltransferase S)	B3GAT2 GLCATS KIAA1963	Homo sapiens (Human)	323	FUNCTION: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. {ECO:0000250|UniProtKB:O35789}.		carbohydrate biosynthetic process [GO:0016051]; carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]	Golgi membrane [GO:0000139]	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018]; metal ion binding [GO:0046872]	Golgi membrane [GO:0000139]; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018]; metal ion binding [GO:0046872]; carbohydrate biosynthetic process [GO:0016051]; carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein.
Q9NQ11	reviewed	AT132_HUMAN	Polyamine-transporting ATPase 13A2 (EC 7.6.2.-)	ATP13A2 PARK9	Homo sapiens (Human)	1180	FUNCTION: ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine (PubMed:31996848). Also stimulates cellular uptake of polyamines and protects against polyamine toxicity (PubMed:31996848). Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024). Contributes to cellular zinc homeostasis (PubMed:24603074). Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress (PubMed:26134396). Required for proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957). Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels (PubMed:27278822). Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Promotes secretion of exosomes as well as secretion of SCNA via exosomes (PubMed:25392495, PubMed:24603074). Plays a role in lipid homeostasis (PubMed:31132336). {ECO:0000269|PubMed:22186024, ECO:0000269|PubMed:22296644, ECO:0000269|PubMed:24603074, ECO:0000269|PubMed:25392495, ECO:0000269|PubMed:26134396, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28137957, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:31132336, ECO:0000269|PubMed:31996848}.		autophagosome organization [GO:1905037]; autophagosome-lysosome fusion [GO:0061909]; autophagy [GO:0006914]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to zinc ion [GO:0071294]; extracellular exosome biogenesis [GO:0097734]; intracellular calcium ion homeostasis [GO:0006874]; intracellular iron ion homeostasis [GO:0006879]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; lipid homeostasis [GO:0055088]; lysosomal transport [GO:0007041]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of lysosomal protein catabolic process [GO:1905166]; peptidyl-aspartic acid autophosphorylation [GO:1990938]; polyamine transmembrane transport [GO:1902047]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein autophosphorylation [GO:0046777]; protein localization to lysosome [GO:0061462]; regulation of autophagosome size [GO:0016243]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of endopeptidase activity [GO:0052548]; regulation of intracellular protein transport [GO:0033157]; regulation of lysosomal protein catabolic process [GO:1905165]; regulation of macroautophagy [GO:0016241]; regulation of mitochondrion organization [GO:0010821]; regulation of neuron apoptotic process [GO:0043523]; regulation of protein localization to nucleus [GO:1900180]; regulation of ubiquitin-specific protease activity [GO:2000152]; spermine transmembrane transport [GO:1903710]; transmembrane transport [GO:0055085]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; transport vesicle [GO:0030133]; vesicle [GO:0031982]	ABC-type polyamine transporter activity [GO:0015417]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; cupric ion binding [GO:1903135]; manganese ion binding [GO:0030145]; P-type ion transporter activity [GO:0015662]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; polyamine transmembrane transporter activity [GO:0015203]; zinc ion binding [GO:0008270]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; transport vesicle [GO:0030133]; vesicle [GO:0031982]; ABC-type polyamine transporter activity [GO:0015417]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; cupric ion binding [GO:1903135]; manganese ion binding [GO:0030145]; P-type ion transporter activity [GO:0015662]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; polyamine transmembrane transporter activity [GO:0015203]; zinc ion binding [GO:0008270]; autophagosome organization [GO:1905037]; autophagosome-lysosome fusion [GO:0061909]; autophagy [GO:0006914]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to zinc ion [GO:0071294]; extracellular exosome biogenesis [GO:0097734]; intracellular calcium ion homeostasis [GO:0006874]; intracellular iron ion homeostasis [GO:0006879]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; lipid homeostasis [GO:0055088]; lysosomal transport [GO:0007041]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of lysosomal protein catabolic process [GO:1905166]; peptidyl-aspartic acid autophosphorylation [GO:1990938]; polyamine transmembrane transport [GO:1902047]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein autophosphorylation [GO:0046777]; protein localization to lysosome [GO:0061462]; regulation of autophagosome size [GO:0016243]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of endopeptidase activity [GO:0052548]; regulation of intracellular protein transport [GO:0033157]; regulation of lysosomal protein catabolic process [GO:1905165]; regulation of macroautophagy [GO:0016241]; regulation of mitochondrion organization [GO:0010821]; regulation of neuron apoptotic process [GO:0043523]; regulation of protein localization to nucleus [GO:1900180]; regulation of ubiquitin-specific protease activity [GO:2000152]; spermine transmembrane transport [GO:1903710]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:21542062, ECO:0000269|PubMed:22186024, ECO:0000269|PubMed:22768177, ECO:0000269|PubMed:24603074, ECO:0000269|PubMed:26134396, ECO:0000269|PubMed:28137957}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:24603074, ECO:0000269|PubMed:25392495, ECO:0000269|PubMed:26134396}; Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:24603074, ECO:0000269|PubMed:25392495}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:24603074}; Multi-pass membrane protein {ECO:0000255}.
Q9NQ25	reviewed	SLAF7_HUMAN	SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319)	SLAMF7 CS1 UNQ576/PRO1138	Homo sapiens (Human)	335	FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528). {ECO:0000250|UniProtKB:Q8BHK6, ECO:0000269|PubMed:11698418, ECO:0000269|PubMed:11802771, ECO:0000269|PubMed:16339536, ECO:0000269|PubMed:23695528, ECO:0000269|Ref.4}.; FUNCTION: Isoform 3 does not mediate any NK cell activation.	MISCELLANEOUS: Proposed to be involved in systemic lupus erythematosus (SLE) disease process. {ECO:0000269|PubMed:23956418}.	adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; T cell activation [GO:0042110]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9NQ29	reviewed	LUC7L_HUMAN	Putative RNA-binding protein Luc7-like 1 (Putative SR protein LUC7B1) (SR+89)	LUC7L LUC7L1	Homo sapiens (Human)	371	FUNCTION: May bind to RNA via its Arg/Ser-rich domain. {ECO:0000269|PubMed:11170747}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	mRNA splice site recognition [GO:0006376]; negative regulation of striated muscle tissue development [GO:0045843]	U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]	identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RS domain binding [GO:0050733]	U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RS domain binding [GO:0050733]; mRNA splice site recognition [GO:0006376]; negative regulation of striated muscle tissue development [GO:0045843]	
Q9NQ30	reviewed	ESM1_HUMAN	Endothelial cell-specific molecule 1 (ESM-1)	ESM1	Homo sapiens (Human)	184	FUNCTION: Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions. {ECO:0000269|PubMed:20616313}.		angiogenesis [GO:0001525]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hepatocyte growth factor receptor signaling pathway [GO:1902204]; sprouting angiogenesis [GO:0002040]	extracellular region [GO:0005576]	hepatocyte growth factor receptor binding [GO:0005171]; integrin binding [GO:0005178]	extracellular region [GO:0005576]; hepatocyte growth factor receptor binding [GO:0005171]; integrin binding [GO:0005178]; angiogenesis [GO:0001525]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hepatocyte growth factor receptor signaling pathway [GO:1902204]; sprouting angiogenesis [GO:0002040]	SUBCELLULAR LOCATION: Secreted.
Q9NQ31	reviewed	AKIP1_HUMAN	A-kinase-interacting protein 1 (Breast cancer-associated gene 3 protein) (PKA-interacting protein) (Proline-rich protein BCA3)	AKIP1 BCA3 C11orf17	Homo sapiens (Human)	210	FUNCTION: Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. {ECO:0000269|PubMed:18178962, ECO:0000269|PubMed:20562110}.		regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; substrate adhesion-dependent cell spreading [GO:0034446]	nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15630084, ECO:0000269|PubMed:18178962}. Note=Locates to punctate spots.
Q9NQ33	reviewed	ASCL3_HUMAN	Achaete-scute homolog 3 (ASH-3) (hASH3) (Class A basic helix-loop-helix protein 42) (bHLHa42) (bHLH transcriptional regulator Sgn-1)	ASCL3 BHLHA42 HASH3 SGN1	Homo sapiens (Human)	180	FUNCTION: Transcriptional repressor. Inhibits myogenesis. Plays a role in progenitor cells which differentiate into ductal and acinar, but not myoepithelial, cell lineages in the salivary glands. Involved in the functions of the microvillar cells and Bowman's glands and probably, in a non-cell-autonomous manner, in the development or regeneration of a complete olfactory epithelium (OE). {ECO:0000250|UniProtKB:Q9JJR7}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q9NQ36	reviewed	SCUB2_HUMAN	Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein CEGP1) (Scube/You)	SCUBE2 CEGP1	Homo sapiens (Human)	999	FUNCTION: Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687). {ECO:0000269|PubMed:22677548, ECO:0000269|PubMed:22902404, ECO:0000269|PubMed:24522195, ECO:0000269|PubMed:27834687, ECO:0000303|PubMed:26875496}.		signal transduction [GO:0007165]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; lipid binding [GO:0008289]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted. Cell surface {ECO:0000269|PubMed:19480626}. Note=Secreted and tethered at the cell surface (PubMed:19480626). {ECO:0000269|PubMed:19480626}.
Q9NQ38	reviewed	ISK5_HUMAN	Serine protease inhibitor Kazal-type 5 (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665]	SPINK5	Homo sapiens (Human)	1064	FUNCTION: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. {ECO:0000269|PubMed:10419450, ECO:0000269|PubMed:17596512, ECO:0000269|PubMed:20533828}.		cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; epidermal cell differentiation [GO:0009913]; epithelial cell differentiation [GO:0030855]; extracellular matrix organization [GO:0030198]; hair cell differentiation [GO:0035315]; negative regulation of angiogenesis [GO:0016525]; negative regulation of antibacterial peptide production [GO:0002787]; negative regulation of immune response [GO:0050777]; negative regulation of proteolysis [GO:0045861]; regulation of cell adhesion [GO:0030155]; regulation of T cell differentiation [GO:0045580]; regulation of timing of anagen [GO:0051884]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; epidermal lamellar body [GO:0097209]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]	serine-type endopeptidase inhibitor activity [GO:0004867]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; epidermal lamellar body [GO:0097209]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; serine-type endopeptidase inhibitor activity [GO:0004867]; cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; epidermal cell differentiation [GO:0009913]; epithelial cell differentiation [GO:0030855]; extracellular matrix organization [GO:0030198]; hair cell differentiation [GO:0035315]; negative regulation of angiogenesis [GO:0016525]; negative regulation of antibacterial peptide production [GO:0002787]; negative regulation of immune response [GO:0050777]; negative regulation of proteolysis [GO:0045861]; regulation of cell adhesion [GO:0030155]; regulation of T cell differentiation [GO:0045580]; regulation of timing of anagen [GO:0051884]	SUBCELLULAR LOCATION: Secreted.
Q9NQ40	reviewed	S52A3_HUMAN	Solute carrier family 52, riboflavin transporter, member 3 (Riboflavin transporter 2) (hRFT2)	SLC52A3 C20orf54 RFT2 RFVT3	Homo sapiens (Human)	469	FUNCTION: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:20463145, PubMed:22273710, PubMed:24264046, PubMed:27702554). Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145). {ECO:0000269|PubMed:20463145, ECO:0000269|PubMed:22273710, ECO:0000269|PubMed:24264046, ECO:0000269|PubMed:27702554, ECO:0000303|PubMed:20463145}.		cellular response to heat [GO:0034605]; flavin adenine dinucleotide biosynthetic process [GO:0072388]; riboflavin metabolic process [GO:0006771]; riboflavin transport [GO:0032218]; sensory perception of sound [GO:0007605]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	riboflavin transmembrane transporter activity [GO:0032217]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; riboflavin transmembrane transporter activity [GO:0032217]; cellular response to heat [GO:0034605]; flavin adenine dinucleotide biosynthetic process [GO:0072388]; riboflavin metabolic process [GO:0006771]; riboflavin transport [GO:0032218]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:20463145, ECO:0000269|PubMed:21512156, ECO:0000269|PubMed:24264046}; Multi-pass membrane protein {ECO:0000269|PubMed:20463145}. Cell membrane {ECO:0000269|PubMed:22273710, ECO:0000269|PubMed:27702554}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:29428966}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:29428966}; Multi-pass membrane protein. Cytoplasm {ECO:0000269|PubMed:29428966}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:29428966}.
Q9NQ48	reviewed	LZTL1_HUMAN	Leucine zipper transcription factor-like protein 1	LZTFL1	Homo sapiens (Human)	299	FUNCTION: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function. {ECO:0000269|PubMed:20233871, ECO:0000269|PubMed:22072986, ECO:0000269|PubMed:22510444}.		flagellated sperm motility [GO:0030317]; negative regulation of protein localization to ciliary membrane [GO:1903568]; negative regulation of protein localization to cilium [GO:1903565]; spermatogenesis [GO:0007283]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; manchette [GO:0002177]	BBSome binding [GO:0062063]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; manchette [GO:0002177]; BBSome binding [GO:0062063]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; flagellated sperm motility [GO:0030317]; negative regulation of protein localization to ciliary membrane [GO:1903568]; negative regulation of protein localization to cilium [GO:1903565]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20233871, ECO:0000269|PubMed:22072986}.
Q9NQ50	reviewed	RM40_HUMAN	Large ribosomal subunit protein mL40 (39S ribosomal protein L40, mitochondrial) (L40mt) (MRP-L40) (Nuclear localization signal-containing protein deleted in velocardiofacial syndrome) (Up-regulated in metastasis)	MRPL40 NLVCF URIM	Homo sapiens (Human)	206			anatomical structure morphogenesis [GO:0009653]; mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]	RNA binding [GO:0003723]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; RNA binding [GO:0003723]; anatomical structure morphogenesis [GO:0009653]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9NQ55	reviewed	SSF1_HUMAN	Suppressor of SWI4 1 homolog (Ssf-1) (Brix domain-containing protein 3) (Peter Pan homolog)	PPAN BXDC3 SSF1	Homo sapiens (Human)	473	FUNCTION: May have a role in cell growth.	MISCELLANEOUS: A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528). {ECO:0000305|PubMed:11278528}.	ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]	nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]	nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Q9NQ66	reviewed	PLCB1_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)	PLCB1 KIAA0581	Homo sapiens (Human)	1216	FUNCTION: Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier. {ECO:0000250|UniProtKB:Q9Z1B3, ECO:0000269|PubMed:9188725}.	MISCELLANEOUS: The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.	activation of meiosis involved in egg activation [GO:0060466]; cellular response to fluoride [GO:1902618]; cellular response to glyceraldehyde [GO:1905631]; cellular response to ionomycin [GO:1904637]; cellular response to vasopressin [GO:1904117]; cerebral cortex development [GO:0021987]; fat cell differentiation [GO:0045444]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; glutamate receptor signaling pathway [GO:0007215]; inositol trisphosphate metabolic process [GO:0032957]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-15-mediated signaling pathway [GO:0035723]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; learning [GO:0007612]; ligand-gated ion channel signaling pathway [GO:1990806]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monocyte extravasation [GO:2000438]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of CD24 production [GO:2000560]; positive regulation of developmental growth [GO:0048639]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of myoblast differentiation [GO:0045663]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of fertilization [GO:0080154]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]; release of sequestered calcium ion into cytosol [GO:0051209]; signal transduction [GO:0007165]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]	calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipase C activity [GO:0004629]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipase C activity [GO:0004629]; activation of meiosis involved in egg activation [GO:0060466]; cellular response to fluoride [GO:1902618]; cellular response to glyceraldehyde [GO:1905631]; cellular response to ionomycin [GO:1904637]; cellular response to vasopressin [GO:1904117]; cerebral cortex development [GO:0021987]; fat cell differentiation [GO:0045444]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; glutamate receptor signaling pathway [GO:0007215]; inositol trisphosphate metabolic process [GO:0032957]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-15-mediated signaling pathway [GO:0035723]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; learning [GO:0007612]; ligand-gated ion channel signaling pathway [GO:1990806]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monocyte extravasation [GO:2000438]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of CD24 production [GO:2000560]; positive regulation of developmental growth [GO:0048639]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of myoblast differentiation [GO:0045663]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of fertilization [GO:0080154]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]; release of sequestered calcium ion into cytosol [GO:0051209]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q9Z1B3}. Cytoplasm {ECO:0000250|UniProtKB:P10687}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250|UniProtKB:Q9Z1B3}.
Q9NQ69	reviewed	LHX9_HUMAN	LIM/homeobox protein Lhx9 (LIM homeobox protein 9)	LHX9	Homo sapiens (Human)	397	FUNCTION: Involved in gonadal development. {ECO:0000250}.		dorsal spinal cord interneuron anterior axon guidance [GO:0097380]; female gonad development [GO:0008585]; gonad morphogenesis [GO:0035262]; male gonad development [GO:0008584]; negative regulation of DNA-templated transcription [GO:0045892]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; dorsal spinal cord interneuron anterior axon guidance [GO:0097380]; female gonad development [GO:0008585]; gonad morphogenesis [GO:0035262]; male gonad development [GO:0008584]; negative regulation of DNA-templated transcription [GO:0045892]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q9NQ75	reviewed	CASS4_HUMAN	Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL)	CASS4 C20orf32 HEFL	Homo sapiens (Human)	786	FUNCTION: Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}.		cell adhesion [GO:0007155]; cell migration [GO:0016477]; positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]	protein tyrosine kinase binding [GO:1990782]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; protein tyrosine kinase binding [GO:1990782]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18256281}. Cell junction, focal adhesion {ECO:0000269|PubMed:18256281}.
Q9NQ76	reviewed	MEPE_HUMAN	Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) (OF45) (Osteoregulin)	MEPE	Homo sapiens (Human)	525	FUNCTION: Promotes renal phosphate excretion and inhibits intestinal phosphate absorption (PubMed:14962809, PubMed:19005008). Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:18162525, PubMed:19998030, PubMed:22766095). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation (PubMed:22341070). {ECO:0000250|UniProtKB:Q8K4L6, ECO:0000269|PubMed:14962809, ECO:0000269|PubMed:18162525, ECO:0000269|PubMed:19005008, ECO:0000269|PubMed:19998030, ECO:0000269|PubMed:22341070, ECO:0000269|PubMed:22766095}.		biomineral tissue development [GO:0031214]; skeletal system development [GO:0001501]	endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	extracellular matrix protein binding [GO:1990430]; extracellular matrix structural constituent [GO:0005201]	endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular matrix protein binding [GO:1990430]; extracellular matrix structural constituent [GO:0005201]; biomineral tissue development [GO:0031214]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11414762, ECO:0000269|PubMed:15108058}.
Q9NQ79	reviewed	CRAC1_HUMAN	Cartilage acidic protein 1 (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC)	CRTAC1 ASPIC1 CEP68	Homo sapiens (Human)	661		MISCELLANEOUS: [Isoform 1]: Shares an exon with the neighboring tail-to-tail oriented gene GOLGA7B.	axonal fasciculation [GO:0007413]	extracellular exosome [GO:0070062]	calcium ion binding [GO:0005509]	extracellular exosome [GO:0070062]; calcium ion binding [GO:0005509]; axonal fasciculation [GO:0007413]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17074475}.
Q9NQ84	reviewed	GPC5C_HUMAN	G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3)	GPRC5C RAIG3 PSEC0087	Homo sapiens (Human)	441	FUNCTION: This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}.		G protein-coupled receptor signaling pathway [GO:0007186]	cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; vesicle [GO:0031982]	G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295]	cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; vesicle [GO:0031982]; G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.
Q9NQ86	reviewed	TRI36_HUMAN	E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728)	TRIM36 RBCC728 RNF98	Homo sapiens (Human)	728	FUNCTION: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}.		acrosome reaction [GO:0007340]; mitotic cytokinesis [GO:0000281]; regulation of cell cycle [GO:0051726]; regulation of microtubule cytoskeleton organization [GO:0070507]; spindle organization [GO:0007051]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	alpha-tubulin binding [GO:0043014]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; alpha-tubulin binding [GO:0043014]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; acrosome reaction [GO:0007340]; mitotic cytokinesis [GO:0000281]; regulation of cell cycle [GO:0051726]; regulation of microtubule cytoskeleton organization [GO:0070507]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28087737}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q80WG7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q80WG7}. Note=Found in the acrosomal region of elongated spermatids and mature sperm. {ECO:0000250|UniProtKB:Q80WG7}.
Q9NQ87	reviewed	HEYL_HUMAN	Hairy/enhancer-of-split related with YRPW motif-like protein (hHeyL) (Class B basic helix-loop-helix protein 33) (bHLHb33) (Hairy-related transcription factor 3) (HRT-3) (hHRT3)	HEYL BHLHB33 HRT3	Homo sapiens (Human)	328	FUNCTION: Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000250, ECO:0000269|PubMed:15485867}.		anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; atrioventricular valve morphogenesis [GO:0003181]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac ventricle morphogenesis [GO:0003208]; cellular response to BMP stimulus [GO:0071773]; circulatory system development [GO:0072359]; endocardial cushion morphogenesis [GO:0003203]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; glomerulus development [GO:0032835]; mesenchymal cell development [GO:0014031]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal tubule development [GO:0072014]; pulmonary valve morphogenesis [GO:0003184]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; ventricular septum morphogenesis [GO:0060412]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	AF-1 domain binding [GO:0050683]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; AF-1 domain binding [GO:0050683]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; atrioventricular valve morphogenesis [GO:0003181]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac ventricle morphogenesis [GO:0003208]; cellular response to BMP stimulus [GO:0071773]; circulatory system development [GO:0072359]; endocardial cushion morphogenesis [GO:0003203]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; glomerulus development [GO:0032835]; mesenchymal cell development [GO:0014031]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal tubule development [GO:0072014]; pulmonary valve morphogenesis [GO:0003184]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Q9NQ88	reviewed	TIGAR_HUMAN	Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase)	TIGAR C12orf5	Homo sapiens (Human)	270	FUNCTION: Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:23726973, PubMed:22887998, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973). {ECO:0000250|UniProtKB:Q8BZA9, ECO:0000269|PubMed:16839880, ECO:0000269|PubMed:19015259, ECO:0000269|PubMed:19713938, ECO:0000269|PubMed:22887998, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:23726973, ECO:0000269|PubMed:23817040, ECO:0000269|PubMed:25928429}.		cardiac muscle cell apoptotic process [GO:0010659]; cellular response to cobalt ion [GO:0071279]; cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; glucose catabolic process to lactate via pyruvate [GO:0019661]; glycolytic process [GO:0006096]; intestinal epithelial cell development [GO:0060576]; mitophagy [GO:0000423]; negative regulation of glucose catabolic process to lactate via pyruvate [GO:1904024]; negative regulation of glycolytic process [GO:0045820]; negative regulation of mitophagy [GO:1901525]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of DNA repair [GO:0045739]; positive regulation of hexokinase activity [GO:1903301]; positive regulation of pentose-phosphate shunt [GO:1905857]; reactive oxygen species metabolic process [GO:0072593]; regulation of pentose-phosphate shunt [GO:0043456]; regulation of response to DNA damage checkpoint signaling [GO:1902153]; response to gamma radiation [GO:0010332]; response to ischemia [GO:0002931]; response to xenobiotic stimulus [GO:0009410]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]	fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to cobalt ion [GO:0071279]; cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; glucose catabolic process to lactate via pyruvate [GO:0019661]; glycolytic process [GO:0006096]; intestinal epithelial cell development [GO:0060576]; mitophagy [GO:0000423]; negative regulation of glucose catabolic process to lactate via pyruvate [GO:1904024]; negative regulation of glycolytic process [GO:0045820]; negative regulation of mitophagy [GO:1901525]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of DNA repair [GO:0045739]; positive regulation of hexokinase activity [GO:1903301]; positive regulation of pentose-phosphate shunt [GO:1905857]; reactive oxygen species metabolic process [GO:0072593]; regulation of pentose-phosphate shunt [GO:0043456]; regulation of response to DNA damage checkpoint signaling [GO:1902153]; response to gamma radiation [GO:0010332]; response to ischemia [GO:0002931]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:25928429}. Nucleus {ECO:0000269|PubMed:25928429}. Mitochondrion {ECO:0000269|PubMed:23185017}. Note=Translocated to the mitochondria during hypoxia in a HIF1A-dependent manner (PubMed:23185017). Colocalizes with HK2 in the mitochondria during hypoxia (PubMed:23185017). Translocated to the nucleus during hypoxia and/or genome stress-induced DNA damage responses in cancer cells (PubMed:25928429). Translocation to the mitochondria is enhanced in ischemic cortex after reperfusion and/or during oxygen and glucose deprivation (OGD)/reoxygenation insult in primary neurons (By similarity). {ECO:0000250|UniProtKB:Q8BZA9, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:25928429}.
Q9NQ90	reviewed	ANO2_HUMAN	Anoctamin-2 (Transmembrane protein 16B)	ANO2 C12orf3 TMEM16B	Homo sapiens (Human)	1003	FUNCTION: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. {ECO:0000269|PubMed:19474308, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21890523, ECO:0000269|PubMed:21984732}.	MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.; MISCELLANEOUS: [Isoform 1]: Splice site between exons 4 and 5 is non-canonical.; MISCELLANEOUS: [Isoform 2]: Splice site between exons 4 and 5 is non-canonical. {ECO:0000305}.; MISCELLANEOUS: A molecular mimicry between ANO2 and Epstein-Barr virus EBNA1 could possibly be linked to multiple sclerosis in the host. {ECO:0000269|PubMed:31375628}.	chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]	chloride channel complex [GO:0034707]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	intracellular calcium activated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983]	chloride channel complex [GO:0034707]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; intracellular calcium activated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983]; chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20056604}; Multi-pass membrane protein {ECO:0000269|PubMed:20056604}.
Q9NQ92	reviewed	COPRS_HUMAN	Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1)	COPRS C17orf79 COPR5	Homo sapiens (Human)	184	FUNCTION: Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18404153}.		chromatin remodeling [GO:0006338]; muscle organ development [GO:0007517]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	histone binding [GO:0042393]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; histone binding [GO:0042393]; chromatin remodeling [GO:0006338]; muscle organ development [GO:0007517]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18404153}.
Q9NQ94	reviewed	A1CF_HUMAN	APOBEC1 complementation factor (APOBEC1-stimulating protein)	A1CF ACF ASP	Homo sapiens (Human)	594	FUNCTION: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. {ECO:0000269|PubMed:10669759, ECO:0000269|PubMed:10781591, ECO:0000269|PubMed:12881431, ECO:0000269|PubMed:24916387}.	MISCELLANEOUS: [Isoform 2]: Major isoform found in 66-78% of cDNA clones. {ECO:0000269|PubMed:11718896}.; MISCELLANEOUS: [Isoform 4]: Does not exhibit APOBEC1 complementation activity. {ECO:0000269|PubMed:11718896, ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Does not exhibit APOBEC1 complementation activity. {ECO:0000269|PubMed:11718896}.; MISCELLANEOUS: [Isoform 6]: Minor isoform found in 2-3% of cDNA clones. {ECO:0000269|PubMed:11718896}.	cytidine to uridine editing [GO:0016554]; embryo implantation [GO:0007566]; mRNA localization resulting in post-transcriptional regulation of gene expression [GO:0010609]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; positive regulation of DNA demethylation [GO:1901537]; protein stabilization [GO:0050821]	apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	enzyme-substrate adaptor activity [GO:0140767]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]	apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; enzyme-substrate adaptor activity [GO:0140767]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; cytidine to uridine editing [GO:0016554]; embryo implantation [GO:0007566]; mRNA localization resulting in post-transcriptional regulation of gene expression [GO:0010609]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; positive regulation of DNA demethylation [GO:1901537]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12881431, ECO:0000269|PubMed:24916387}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12881431}. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}.
Q9NQA5	reviewed	TRPV5_HUMAN	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3)	TRPV5 ECAC1	Homo sapiens (Human)	729	FUNCTION: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250|UniProtKB:P69744, ECO:0000250|UniProtKB:Q9XSM3, ECO:0000269|PubMed:11549322, ECO:0000269|PubMed:18768590}.		calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; protein homotetramerization [GO:0051289]; regulation of urine volume [GO:0035809]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; protein homotetramerization [GO:0051289]; regulation of urine volume [GO:0035809]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:18768590}; Multi-pass membrane protein {ECO:0000269|PubMed:18768590}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3 (PubMed:18768590). {ECO:0000250|UniProtKB:P69744, ECO:0000269|PubMed:18768590}.
Q9NQB0	reviewed	TF7L2_HUMAN	Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)	TCF7L2 TCF4	Homo sapiens (Human)	619	FUNCTION: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}.	MISCELLANEOUS: [Isoform 12]: Low expression in pancreas and colon. {ECO:0000305}.; MISCELLANEOUS: [Isoform 13]: Common splicing form, lowest expression in skeletal muscle. {ECO:0000305}.; MISCELLANEOUS: [Isoform 14]: High transcriptional activity. Major isoform in liver. {ECO:0000305}.	blood vessel development [GO:0001568]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [GO:0044334]; fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; maintenance of DNA repeat elements [GO:0043570]; myoblast fate commitment [GO:0048625]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; pancreas development [GO:0031016]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]; positive regulation of insulin secretion [GO:0032024]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of hormone metabolic process [GO:0032350]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]	beta-catenin-TCF complex [GO:1990907]; beta-catenin-TCF7L2 complex [GO:0070369]; catenin-TCF7L2 complex [GO:0071664]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-DNA complex [GO:0032993]	armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; gamma-catenin binding [GO:0045295]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]	beta-catenin-TCF complex [GO:1990907]; beta-catenin-TCF7L2 complex [GO:0070369]; catenin-TCF7L2 complex [GO:0071664]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-DNA complex [GO:0032993]; armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; gamma-catenin binding [GO:0045295]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; blood vessel development [GO:0001568]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [GO:0044334]; fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; maintenance of DNA repeat elements [GO:0043570]; myoblast fate commitment [GO:0048625]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; pancreas development [GO:0031016]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]; positive regulation of insulin secretion [GO:0032024]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of hormone metabolic process [GO:0032350]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]	SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9916915}. Nucleus {ECO:0000269|PubMed:19304756}. Note=Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.
Q9NQC1	reviewed	JADE2_HUMAN	E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15)	JADE2 KIAA0239 PHF15	Homo sapiens (Human)	790	FUNCTION: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}.		protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	extracellular exosome [GO:0070062]; histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654]	histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; metal ion binding [GO:0046872]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q9NQC3	reviewed	RTN4_HUMAN	Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)	RTN4 KIAA0886 NOGO My043 SP1507	Homo sapiens (Human)	1192	FUNCTION: Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:27619977, PubMed:25612671, PubMed:24262037). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977, PubMed:25612671, PubMed:24262037, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}.		apoptotic process [GO:0006915]; axonal fasciculation [GO:0007413]; blastocyst formation [GO:0001825]; brain development [GO:0007420]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell adhesion involved in sprouting angiogenesis [GO:0120078]; cell migration involved in vasculogenesis [GO:0035441]; cellular response to hypoxia [GO:0071456]; central nervous system vasculogenesis [GO:0022009]; cerebral cortex radial glia-guided migration [GO:0021801]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; endoplasmic reticulum tubular network organization [GO:0071786]; intracellular sphingolipid homeostasis [GO:0090156]; leukocyte migration involved in inflammatory response [GO:0002523]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of axon extension [GO:0030517]; negative regulation of cell growth [GO:0030308]; negative regulation of vasculogenesis [GO:2001213]; neuron differentiation [GO:0030182]; nuclear pore complex assembly [GO:0051292]; positive regulation of angiogenesis [GO:0045766]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERBB3 signaling pathway [GO:1905580]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of macrophage migration [GO:1905523]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of cell migration [GO:0030334]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; axonal fasciculation [GO:0007413]; blastocyst formation [GO:0001825]; brain development [GO:0007420]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell adhesion involved in sprouting angiogenesis [GO:0120078]; cell migration involved in vasculogenesis [GO:0035441]; cellular response to hypoxia [GO:0071456]; central nervous system vasculogenesis [GO:0022009]; cerebral cortex radial glia-guided migration [GO:0021801]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; endoplasmic reticulum tubular network organization [GO:0071786]; intracellular sphingolipid homeostasis [GO:0090156]; leukocyte migration involved in inflammatory response [GO:0002523]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of axon extension [GO:0030517]; negative regulation of cell growth [GO:0030308]; negative regulation of vasculogenesis [GO:2001213]; neuron differentiation [GO:0030182]; nuclear pore complex assembly [GO:0051292]; positive regulation of angiogenesis [GO:0045766]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERBB3 signaling pathway [GO:1905580]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of macrophage migration [GO:1905523]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of cell migration [GO:0030334]	SUBCELLULAR LOCATION: [Isoform A]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289}; Multi-pass membrane protein {ECO:0000255}. Cell membrane; Multi-pass membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000269|PubMed:27786289}. Note=Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network (PubMed:27619977). Co-localizes with TMEM33 at the ER sheets. {ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:27619977}.; SUBCELLULAR LOCATION: [Isoform B]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27786289}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15034570}; Multi-pass membrane protein {ECO:0000255}; Extracellular side {ECO:0000269|PubMed:15034570}. Cell junction {ECO:0000269|PubMed:21183689}. Note=Mainly located on endoplasmic reticulum tubules and sheet edges (PubMed:27786289). Upon ICAM1 engagement, redistributed toward endothelial junctions where interacts with CDH5 (PubMed:21183689). {ECO:0000269|PubMed:21183689, ECO:0000269|PubMed:27786289}.; SUBCELLULAR LOCATION: [Isoform C]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25612671}; Multi-pass membrane protein {ECO:0000255}.
Q9NQC7	reviewed	CYLD_HUMAN	Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)	CYLD CYLD1 KIAA0849 HSPC057	Homo sapiens (Human)	956	FUNCTION: Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18636086, PubMed:26670046, PubMed:27458237, PubMed:26997266, PubMed:27591049, PubMed:29291351, PubMed:18313383, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26997266, PubMed:26670046, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Removes also 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}.		cell cycle [GO:0007049]; innate immune response [GO:0045087]; necroptotic process [GO:0070266]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-18-mediated signaling pathway [GO:2000493]; negative regulation of JNK cascade [GO:0046329]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of type I interferon production [GO:0032480]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; protein deubiquitination [GO:0016579]; protein linear deubiquitination [GO:1990108]; regulation of cilium assembly [GO:1902017]; regulation of inflammatory response [GO:0050727]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of mitotic cell cycle [GO:0007346]; regulation of necroptotic process [GO:0060544]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; Wnt signaling pathway [GO:0016055]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cytosol [GO:0005829]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819]	cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578]; Met1-linked polyubiquitin deubiquitinase activity [GO:0061815]; proline-rich region binding [GO:0070064]; protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cytosol [GO:0005829]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819]; cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578]; Met1-linked polyubiquitin deubiquitinase activity [GO:0061815]; proline-rich region binding [GO:0070064]; protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; innate immune response [GO:0045087]; necroptotic process [GO:0070266]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-18-mediated signaling pathway [GO:2000493]; negative regulation of JNK cascade [GO:0046329]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of type I interferon production [GO:0032480]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; protein deubiquitination [GO:0016579]; protein linear deubiquitination [GO:1990108]; regulation of cilium assembly [GO:1902017]; regulation of inflammatory response [GO:0050727]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of mitotic cell cycle [GO:0007346]; regulation of necroptotic process [GO:0060544]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:32185393}. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25134987}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25134987}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80TQ2}. Note=Detected at the microtubule cytoskeleton during interphase. Detected at the midbody during telophase. During metaphase, it remains localized to the centrosome but is also present along the spindle (PubMed:25134987). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:25134987}.
Q9NQC8	reviewed	IFT46_HUMAN	Intraflagellar transport protein 46 homolog	IFT46 C11orf2 C11orf60	Homo sapiens (Human)	304	FUNCTION: Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). {ECO:0000250}.		cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; protein stabilization [GO:0050821]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]		centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Note=Expression is concentrated at the cilium basal body but is also detected along the length of the cilium. {ECO:0000250}.
Q9NQE9	reviewed	HINT3_HUMAN	Adenosine 5'-monophosphoramidase HINT3 (EC 3.9.1.-) (Histidine triad nucleotide-binding protein 3) (HINT-3)	HINT3	Homo sapiens (Human)	182	FUNCTION: Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:17870088). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (PubMed:17870088). Hydrolyzes 3-indolepropionic acyl-adenylate and fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17870088). {ECO:0000269|PubMed:17870088}.			cytoplasm [GO:0005737]; nucleus [GO:0005634]	adenosine 5'-monophosphoramidase activity [GO:0043530]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; adenosine 5'-monophosphoramidase activity [GO:0043530]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17870088}. Nucleus {ECO:0000269|PubMed:17870088}. Note=Localized as aggregates in the cytoplasm and the nucleus.
Q9NQG1	reviewed	MANBL_HUMAN	Protein MANBAL	MANBAL	Homo sapiens (Human)	85				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NQG5	reviewed	RPR1B_HUMAN	Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor)	RPRD1B C20orf77 CREPT	Homo sapiens (Human)	326	FUNCTION: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.		mRNA 3'-end processing [GO:0031124]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle process [GO:0010564]; RNA polymerase II promoter clearance [GO:0001111]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550]	identical protein binding [GO:0042802]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550]; identical protein binding [GO:0042802]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993]; mRNA 3'-end processing [GO:0031124]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle process [GO:0010564]; RNA polymerase II promoter clearance [GO:0001111]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791}.
Q9NQG6	reviewed	MID51_HUMAN	Mitochondrial dynamics protein MIEF1 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein)	MIEF1 MID51 SMCR7L	Homo sapiens (Human)	463	FUNCTION: Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:21701560, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:24515348, ECO:0000269|PubMed:29083303}.		cellular response to hypoxia [GO:0071456]; mitochondrial fission [GO:0000266]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	ADP binding [GO:0043531]; GDP binding [GO:0019003]; identical protein binding [GO:0042802]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; ADP binding [GO:0043531]; GDP binding [GO:0019003]; identical protein binding [GO:0042802]; cellular response to hypoxia [GO:0071456]; mitochondrial fission [GO:0000266]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:21701560, ECO:0000269|PubMed:24515348}; Single-pass membrane protein {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:21701560, ECO:0000269|PubMed:24515348}.
Q9NQG7	reviewed	HPS4_HUMAN	BLOC-3 complex member HPS4 (Hermansky-Pudlak syndrome 4 protein) (Light-ear protein homolog)	HPS4 KIAA1667	Homo sapiens (Human)	708	FUNCTION: Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991). {ECO:0000269|PubMed:23084991}.		blood coagulation [GO:0007596]; hemostasis [GO:0007599]; intracellular transport [GO:0046907]; lysosome organization [GO:0007040]; melanocyte differentiation [GO:0030318]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; positive regulation of eye pigmentation [GO:0048075]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192]	BLOC-3 complex [GO:0031085]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; platelet dense granule [GO:0042827]	guanyl-nucleotide exchange factor activity [GO:0005085]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]	BLOC-3 complex [GO:0031085]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; platelet dense granule [GO:0042827]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; blood coagulation [GO:0007596]; hemostasis [GO:0007599]; intracellular transport [GO:0046907]; lysosome organization [GO:0007040]; melanocyte differentiation [GO:0030318]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; positive regulation of eye pigmentation [GO:0048075]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192]	
Q9NQH7	reviewed	XPP3_HUMAN	Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3)	XPNPEP3	Homo sapiens (Human)	507	FUNCTION: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala (PubMed:25609706, PubMed:28476889). Also shows low activity towards peptides with Ala or Ser at the P1 position (PubMed:28476889). {ECO:0000269|PubMed:25609706, ECO:0000269|PubMed:28476889}.; FUNCTION: [Isoform 1]: Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling. {ECO:0000269|PubMed:25609706}.		glomerular filtration [GO:0003094]; protein processing [GO:0016485]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803]; glomerular filtration [GO:0003094]; protein processing [GO:0016485]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:20179356, ECO:0000269|PubMed:25609706}. Cytoplasm {ECO:0000269|PubMed:25609706}. Note=Mainly mitochondrial. Translocates to the cytoplasm following TNFRSF1B activation. {ECO:0000269|PubMed:25609706}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:25609706}.
Q9NQI0	reviewed	DDX4_HUMAN	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog)	DDX4 VASA	Homo sapiens (Human)	724	FUNCTION: ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (By similarity). {ECO:0000250|UniProtKB:Q61496, ECO:0000269|PubMed:10920202, ECO:0000269|PubMed:21034600}.		cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; gamete generation [GO:0007276]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; piRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141006]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P granule [GO:0043186]; perinuclear region of cytoplasm [GO:0048471]; pi-body [GO:0071546]; piP-body [GO:0071547]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; molecular condensate scaffold activity [GO:0140693]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P granule [GO:0043186]; perinuclear region of cytoplasm [GO:0048471]; pi-body [GO:0071546]; piP-body [GO:0071547]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; molecular condensate scaffold activity [GO:0140693]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; gamete generation [GO:0007276]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; piRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141006]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q61496}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q61496}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q61496}.
Q9NQL2	reviewed	RRAGD_HUMAN	Ras-related GTP-binding protein D (Rag D) (RagD) (EC 3.6.5.-)	RRAGD	Homo sapiens (Human)	400	FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:34607910). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagD/RRAGD is in its active form when GDP-bound RagD/RRAGD forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagD/RRAGD heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279). In its active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagD/RRAGD mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34607910}.		cellular response to amino acid stimulus [GO:0071230]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to starvation [GO:0009267]; negative regulation of autophagy [GO:0010507]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gtr1-Gtr2 GTPase complex [GO:1990131]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gtr1-Gtr2 GTPase complex [GO:1990131]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; cellular response to amino acid stimulus [GO:0071230]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to starvation [GO:0009267]; negative regulation of autophagy [GO:0010507]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11073942}. Nucleus {ECO:0000269|PubMed:11073942}. Lysosome membrane {ECO:0000269|PubMed:20381137}. Note=Predominantly cytoplasmic (PubMed:11073942). Recruited to the lysosome surface by the Ragulator complex (PubMed:20381137). May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942). {ECO:0000269|PubMed:11073942, ECO:0000269|PubMed:20381137}.
Q9NQL9	reviewed	DMRT3_HUMAN	Doublesex- and mab-3-related transcription factor 3	DMRT3 DMRTA3	Homo sapiens (Human)	472	FUNCTION: Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity). {ECO:0000250}.	MISCELLANEOUS: DMRT3 is a marker for a subset of spinal cord neurons (dI6).	adult walking behavior [GO:0007628]; male sex differentiation [GO:0046661]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]; transmission of nerve impulse [GO:0019226]; ventral spinal cord interneuron specification [GO:0021521]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; adult walking behavior [GO:0007628]; male sex differentiation [GO:0046661]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]; transmission of nerve impulse [GO:0019226]; ventral spinal cord interneuron specification [GO:0021521]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Q9NQM4	reviewed	DAAF6_HUMAN	Dynein axonemal assembly factor 6 (PIH1 domain-containing protein 3) (Sarcoma antigen NY-SAR-97)	DNAAF6 CXorf41 PIH1D3	Homo sapiens (Human)	214	FUNCTION: Plays a role in cytoplasmic pre-assembly of axonemal dynein. {ECO:0000269|PubMed:28041644, ECO:0000269|PubMed:28176794}.		axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158]	cytoplasm [GO:0005737]; trans-Golgi network [GO:0005802]	dynein intermediate chain binding [GO:0045505]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; trans-Golgi network [GO:0005802]; dynein intermediate chain binding [GO:0045505]; protein-folding chaperone binding [GO:0051087]; axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28176794}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:28176794}. Note=Localized to the cytoplasm of spermatogenic cells. {ECO:0000250|UniProtKB:Q3KNI6}.
Q9NQP4	reviewed	PFD4_HUMAN	Prefoldin subunit 4 (Protein C-1)	PFDN4 PFD4	Homo sapiens (Human)	134	FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.		chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]	amyloid-beta binding [GO:0001540]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]; amyloid-beta binding [GO:0001540]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17936702}. Cytoplasm {ECO:0000269|PubMed:17936702}. Mitochondrion {ECO:0000269|PubMed:17936702}.
Q9NQQ7	reviewed	S35C2_HUMAN	Solute carrier family 35 member C2 (Ovarian cancer-overexpressed gene 1 protein)	SLC35C2 C20orf5 OVCOV1 CGI-15	Homo sapiens (Human)	365	FUNCTION: May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. {ECO:0000269|PubMed:20837470}.		fucosylation [GO:0036065]; negative regulation of gene expression [GO:0010629]; positive regulation of Notch signaling pathway [GO:0045747]; UDP-glucose transmembrane transport [GO:0015786]	cis-Golgi network [GO:0005801]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	antiporter activity [GO:0015297]	cis-Golgi network [GO:0005801]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; antiporter activity [GO:0015297]; fucosylation [GO:0036065]; negative regulation of gene expression [GO:0010629]; positive regulation of Notch signaling pathway [GO:0045747]; UDP-glucose transmembrane transport [GO:0015786]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:20837470}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:20837470}; Multi-pass membrane protein {ECO:0000255}.
Q9NQR1	reviewed	KMT5A_HUMAN	N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.361) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8)	KMT5A PRSET7 SET07 SET8 SETD8	Homo sapiens (Human)	393	FUNCTION: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:17707234, PubMed:27338793). Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1) (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:27338793, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:16517599). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:16517599). Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:16517599). Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:16517599). Involved in chromosome condensation and proper cytokinesis (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:16517599). Nucleosomes are preferred as substrate compared to free histones (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:16517599). Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (PubMed:17707234). Plays a negative role in TGF-beta response regulation and a positive role in cell migration (PubMed:23478445). {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12121615, ECO:0000269|PubMed:15200950, ECO:0000269|PubMed:15933069, ECO:0000269|PubMed:15933070, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:16517599, ECO:0000269|PubMed:17707234, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:27338793}.		cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polytene chromosome [GO:0005700]	histone H4 methyltransferase activity [GO:0140939]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone methyltransferase activity [GO:0042054]; lysine N-methyltransferase activity [GO:0016278]; protein-lysine N-methyltransferase activity [GO:0016279]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polytene chromosome [GO:0005700]; histone H4 methyltransferase activity [GO:0140939]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone methyltransferase activity [GO:0042054]; lysine N-methyltransferase activity [GO:0016278]; protein-lysine N-methyltransferase activity [GO:0016279]; transcription corepressor activity [GO:0003714]; cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12086618}. Chromosome {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12208845, ECO:0000269|PubMed:23468428}. Note=Specifically localizes to mitotic chromosomes (PubMed:12208845). Colocalized with SIRT2 at mitotic foci (PubMed:23468428). Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress-dependent manner (PubMed:23468428). Associates with silent chromatin on euchromatic arms (PubMed:12086618). Not associated with constitutive heterochromatin (PubMed:12086618). {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12208845, ECO:0000269|PubMed:23468428}.
Q9NQR4	reviewed	NIT2_HUMAN	Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2)	NIT2 CUA002	Homo sapiens (Human)	276	FUNCTION: Has omega-amidase activity (PubMed:22674578, PubMed:19595734). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734). {ECO:0000269|PubMed:19595734, ECO:0000269|PubMed:22674578}.		asparagine metabolic process [GO:0006528]; glutamine metabolic process [GO:0006541]; oxaloacetate metabolic process [GO:0006107]	centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	2-oxoglutaramate amidase activity [GO:0106008]; omega-amidase activity [GO:0050152]	centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; 2-oxoglutaramate amidase activity [GO:0106008]; omega-amidase activity [GO:0050152]; asparagine metabolic process [GO:0006528]; glutamine metabolic process [GO:0006541]; oxaloacetate metabolic process [GO:0006107]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17488281}.
Q9NQR9	reviewed	G6PC2_HUMAN	Glucose-6-phosphatase 2 (G-6-Pase 2) (G6Pase 2) (EC 3.1.3.9) (Islet-specific glucose-6-phosphatase catalytic subunit-related protein)	G6PC2 IGRP	Homo sapiens (Human)	355	FUNCTION: May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). {ECO:0000250}.		gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose homeostasis [GO:0042593]; regulation of insulin secretion [GO:0050796]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	glucose-6-phosphatase activity [GO:0004346]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; glucose-6-phosphatase activity [GO:0004346]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose homeostasis [GO:0042593]; regulation of insulin secretion [GO:0050796]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15044018}; Multi-pass membrane protein {ECO:0000269|PubMed:15044018}.
Q9NQS3	reviewed	NECT3_HUMAN	Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)	NECTIN3 PRR3 PVRL3	Homo sapiens (Human)	549	FUNCTION: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. {ECO:0000269|PubMed:16216929}.		establishment of protein localization to plasma membrane [GO:0061951]; fertilization [GO:0009566]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens morphogenesis in camera-type eye [GO:0002089]; protein localization to cell junction [GO:1902414]; retina morphogenesis in camera-type eye [GO:0060042]; viral entry into host cell [GO:0046718]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; axon [GO:0030424]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; axon [GO:0030424]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; establishment of protein localization to plasma membrane [GO:0061951]; fertilization [GO:0009566]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens morphogenesis in camera-type eye [GO:0002089]; protein localization to cell junction [GO:1902414]; retina morphogenesis in camera-type eye [GO:0060042]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26038560}; Single-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250}.
Q9NQS5	reviewed	GPR84_HUMAN	G-protein coupled receptor 84 (Inflammation-related G-protein coupled receptor EX33)	GPR84 EX33	Homo sapiens (Human)	396	FUNCTION: Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system. {ECO:0000269|PubMed:16966319}.		neuropeptide signaling pathway [GO:0007218]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	urotensin II receptor activity [GO:0001604]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; urotensin II receptor activity [GO:0001604]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9NQS7	reviewed	INCE_HUMAN	Inner centromere protein	INCENP	Homo sapiens (Human)	918	FUNCTION: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}.		chromosome segregation [GO:0007059]; meiotic spindle midzone assembly [GO:0051257]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of protein phosphorylation [GO:0001934]	central element [GO:0000801]; chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; lateral element [GO:0000800]; meiotic spindle midzone [GO:1990385]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991]; spindle [GO:0005819]	molecular function activator activity [GO:0140677]	central element [GO:0000801]; chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; lateral element [GO:0000800]; meiotic spindle midzone [GO:1990385]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; molecular function activator activity [GO:0140677]; chromosome segregation [GO:0007059]; meiotic spindle midzone assembly [GO:0051257]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of protein phosphorylation [GO:0001934]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11453556}. Chromosome, centromere {ECO:0000269|PubMed:11453556, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11453556, ECO:0000269|PubMed:15316025}. Midbody {ECO:0000269|PubMed:15316025}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14610074}. Note=Colocalized at synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocenters. Colocalizes with AURKB at a connecting strand traversing the centromere region and joining sister kinetochores, in metaphase II centromeres. This strand disappears at the metaphase II/anaphase II transition and relocalizes to the spindle midzone (By similarity). Colocalizes with AURKB at mitotic chromosomes (PubMed:11453556). Localizes to inner kinetochore (PubMed:16760428). Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:15316025). Cocalizes to the equatorial cell cortex at anaphase (PubMed:11453556). {ECO:0000250|UniProtKB:Q9WU62, ECO:0000269|PubMed:11453556, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428}.
Q9NQT4	reviewed	EXOS5_HUMAN	Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B)	EXOSC5 CML28 RRP46	Homo sapiens (Human)	235	FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (PubMed:11782436, PubMed:21269460). In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity (PubMed:20660080). {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:20660080, ECO:0000269|PubMed:21269460}.		defense response to virus [GO:0051607]; DNA deamination [GO:0045006]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5'-RNA exonuclease activity [GO:0000175]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5'-RNA exonuclease activity [GO:0000175]; RNA binding [GO:0003723]; defense response to virus [GO:0051607]; DNA deamination [GO:0045006]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}.
Q9NQT5	reviewed	EXOS3_HUMAN	Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10)	EXOSC3 RRP40 CGI-102	Homo sapiens (Human)	275	FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:21255825}.		CUT catabolic process [GO:0071034]; DNA deamination [GO:0045006]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; isotype switching [GO:0045190]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of isotype switching [GO:0045830]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5'-RNA exonuclease activity [GO:0000175]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5'-RNA exonuclease activity [GO:0000175]; RNA binding [GO:0003723]; CUT catabolic process [GO:0071034]; DNA deamination [GO:0045006]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; isotype switching [GO:0045190]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of isotype switching [GO:0045830]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000269|PubMed:20531389}. Nucleus {ECO:0000269|PubMed:17545563}.
Q9NQT8	reviewed	KI13B_HUMAN	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN)	KIF13B GAKIN KIAA0639	Homo sapiens (Human)	1826	FUNCTION: Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}.		cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; protein targeting [GO:0006605]; regulation of axonogenesis [GO:0050770]; signal transduction [GO:0007165]; T cell activation [GO:0042110]	axon [GO:0030424]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]	14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; protein kinase binding [GO:0019901]	axon [GO:0030424]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; protein kinase binding [GO:0019901]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; protein targeting [GO:0006605]; regulation of axonogenesis [GO:0050770]; signal transduction [GO:0007165]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20194617}. Cell projection, axon {ECO:0000269|PubMed:20194617}. Note=accumulates at the distal part of the microtubules in the tips of axons, but not of dendrites.
Q9NQU5	reviewed	PAK6_HUMAN	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)	PAK6 PAK5	Homo sapiens (Human)	681	FUNCTION: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}.		apoptotic process [GO:0006915]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; locomotory behavior [GO:0007626]; memory [GO:0007613]; neuron projection arborization [GO:0140058]; neuron projection extension [GO:1990138]; phosphorylation [GO:0016310]; regulation of DNA-templated transcription [GO:0006355]; regulation of MAPK cascade [GO:0043408]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; locomotory behavior [GO:0007626]; memory [GO:0007613]; neuron projection arborization [GO:0140058]; neuron projection extension [GO:1990138]; phosphorylation [GO:0016310]; regulation of DNA-templated transcription [GO:0006355]; regulation of MAPK cascade [GO:0043408]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
Q9NQV5	reviewed	PRD11_HUMAN	PR domain-containing protein 11 (EC 2.1.1.-)	PRDM11 PFM8	Homo sapiens (Human)	511	FUNCTION: May be involved in transcription regulation. {ECO:0000269|PubMed:25499759}.		methylation [GO:0032259]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast apoptotic process [GO:2000271]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of MAPK cascade [GO:0043408]	cytosol [GO:0005829]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; methyltransferase activity [GO:0008168]	cytosol [GO:0005829]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; methyltransferase activity [GO:0008168]; methylation [GO:0032259]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast apoptotic process [GO:2000271]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of MAPK cascade [GO:0043408]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25499759}. Cytoplasm {ECO:0000269|PubMed:25499759}.
Q9NQV6	reviewed	PRD10_HUMAN	PR domain zinc finger protein 10 (EC 2.1.1.-) (PR domain-containing protein 10) (Tristanin)	PRDM10 KIAA1231 PFM7 TRIS	Homo sapiens (Human)	1147	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9NQV7	reviewed	PRDM9_HUMAN	Histone-lysine N-methyltransferase PRDM9 (PR domain zinc finger protein 9) (PR domain-containing protein 9) (Protein-lysine N-methyltransferase PRDM9) (EC 2.1.1.-) ([histone H3]-lysine36 N-trimethyltransferase PRDM9) (EC 2.1.1.359) ([histone H3]-lysine4 N-trimethyltransferase PRDM9) (EC 2.1.1.354) ([histone H3]-lysine9 N-trimethyltransferase PRDM9) (EC 2.1.1.355) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.361)	PRDM9 PFM6	Homo sapiens (Human)	894	FUNCTION: Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:24634223, PubMed:24095733, PubMed:26833727, PubMed:27129774). Can also methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24095733, PubMed:24634223, PubMed:26833727). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (By similarity). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:26833727). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (By similarity). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (By similarity). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (By similarity). In addition performs automethylation (By similarity). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (By similarity). {ECO:0000250|UniProtKB:Q96EQ9, ECO:0000269|PubMed:24095733, ECO:0000269|PubMed:24634223, ECO:0000269|PubMed:26833727}.		double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; male gamete generation [GO:0048232]; meiotic gene conversion [GO:0006311]; methylation [GO:0032259]; negative regulation of apoptotic process [GO:0043066]; positive regulation of fertilization [GO:1905516]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; recombination hotspot binding [GO:0010844]; transcription cis-regulatory region binding [GO:0000976]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; recombination hotspot binding [GO:0010844]; transcription cis-regulatory region binding [GO:0000976]; double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; male gamete generation [GO:0048232]; meiotic gene conversion [GO:0006311]; methylation [GO:0032259]; negative regulation of apoptotic process [GO:0043066]; positive regulation of fertilization [GO:1905516]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96EQ9}. Chromosome {ECO:0000250|UniProtKB:Q96EQ9}. Note=Localizes in nuclei of pre-leptotene, leptotene, and early to mid-zygotene spermatocytes. {ECO:0000250|UniProtKB:Q96EQ9}.
Q9NQV8	reviewed	PRDM8_HUMAN	PR domain zinc finger protein 8 (EC 2.1.1.-) (PR domain-containing protein 8)	PRDM8 PFM5	Homo sapiens (Human)	689	FUNCTION: Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity). {ECO:0000250|UniProtKB:Q8BZ97}.		corpus callosum morphogenesis [GO:0021540]; corticospinal tract morphogenesis [GO:0021957]; methylation [GO:0032259]; oligodendrocyte development [GO:0014003]; regulation of DNA-templated transcription [GO:0006355]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K9 methyltransferase activity [GO:0046974]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K9 methyltransferase activity [GO:0046974]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; corpus callosum morphogenesis [GO:0021540]; corticospinal tract morphogenesis [GO:0021957]; methylation [GO:0032259]; oligodendrocyte development [GO:0014003]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22961547}.
Q9NQW1	reviewed	SC31B_HUMAN	Protein transport protein Sec31B (SEC31-like protein 2) (SEC31-related protein B) (SEC31B-1)	SEC31B SEC31L2	Homo sapiens (Human)	1179	FUNCTION: As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum. {ECO:0000269|PubMed:16495487}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; intracellular protein transport [GO:0006886]	COPII vesicle coat [GO:0030127]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; vesicle coat [GO:0030120]	structural molecule activity [GO:0005198]	COPII vesicle coat [GO:0030127]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; vesicle coat [GO:0030120]; structural molecule activity [GO:0005198]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16495487}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:16495487}; Peripheral membrane protein {ECO:0000269|PubMed:16495487}; Cytoplasmic side {ECO:0000269|PubMed:16495487}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16495487}; Peripheral membrane protein {ECO:0000269|PubMed:16495487}.
Q9NQW5	reviewed	PRDM7_HUMAN	Histone-lysine N-methyltransferase PRDM7 (EC 2.1.1.-) (PR domain zinc finger protein 7) (PR domain-containing protein 7) ([histone H3]-lysine4 N-methyltransferase PRDM7)	PRDM7 PFM4	Homo sapiens (Human)	492	FUNCTION: Histone methyltransferase that selectively methylates 'Lys-4' of dimethylated histone H3 (H3K4me2) to produce trimethylated 'Lys-4' histone H3 (H3K4me3). May play a role in epigenetic regulation of gene expression by defining an active chromatin state. {ECO:0000269|PubMed:27129774}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	methylation [GO:0032259]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]	chromosome [GO:0005694]; nucleus [GO:0005634]	histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; recombination hotspot binding [GO:0010844]	chromosome [GO:0005694]; nucleus [GO:0005634]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; recombination hotspot binding [GO:0010844]; methylation [GO:0032259]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
Q9NQW6	reviewed	ANLN_HUMAN	Anillin	ANLN	Homo sapiens (Human)	1124	FUNCTION: Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.		actomyosin contractile ring assembly [GO:0000915]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic cytokinesis [GO:0000281]; podocyte cell migration [GO:0090521]; positive regulation of bleb assembly [GO:1904172]; regulation of exit from mitosis [GO:0007096]; septin ring assembly [GO:0000921]; septin ring organization [GO:0031106]	actin cytoskeleton [GO:0015629]; actomyosin contractile ring [GO:0005826]; bleb [GO:0032059]; cell cortex [GO:0005938]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]	actin binding [GO:0003779]; cadherin binding [GO:0045296]	actin cytoskeleton [GO:0015629]; actomyosin contractile ring [GO:0005826]; bleb [GO:0032059]; cell cortex [GO:0005938]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; actomyosin contractile ring assembly [GO:0000915]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic cytokinesis [GO:0000281]; podocyte cell migration [GO:0090521]; positive regulation of bleb assembly [GO:1904172]; regulation of exit from mitosis [GO:0007096]; septin ring assembly [GO:0000921]; septin ring organization [GO:0031106]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex {ECO:0000269|PubMed:23870127}. Cell projection, bleb {ECO:0000269|PubMed:23870127}. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.
Q9NQW7	reviewed	XPP1_HUMAN	Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)	XPNPEP1 XPNPEPL XPNPEPL1	Homo sapiens (Human)	623	FUNCTION: Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:11106490, PubMed:35165443, PubMed:18515364). Contributes to the degradation of bradykinin (PubMed:11106490). {ECO:0000269|PubMed:11106490, ECO:0000269|PubMed:18515364, ECO:0000269|PubMed:35165443}.		bradykinin catabolic process [GO:0010815]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803]; bradykinin catabolic process [GO:0010815]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11106490}.
Q9NQW8	reviewed	CNGB3_HUMAN	Cyclic nucleotide-gated cation channel beta-3 (Cone photoreceptor cGMP-gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel beta-3) (CNG channel beta-3)	CNGB3	Homo sapiens (Human)	809	FUNCTION: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO:0000250, ECO:0000269|PubMed:10888875}.		monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; signal transduction [GO:0007165]; visual perception [GO:0007601]	intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]	cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877]	intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]; cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NQX0	reviewed	PRDM6_HUMAN	Putative histone-lysine N-methyltransferase PRDM6 (EC 2.1.1.361) (PR domain zinc finger protein 6) (PR domain-containing protein 6)	PRDM6 PFM3	Homo sapiens (Human)	595	FUNCTION: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. {ECO:0000250|UniProtKB:Q3UZD5}.		methylation [GO:0032259]; negative regulation of smooth muscle cell differentiation [GO:0051151]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; regulation of gene expression [GO:0010468]	nucleus [GO:0005634]	histone H4K20 monomethyltransferase activity [GO:0140944]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; histone H4K20 monomethyltransferase activity [GO:0140944]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methylation [GO:0032259]; negative regulation of smooth muscle cell differentiation [GO:0051151]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3UZD5}.
Q9NQX1	reviewed	PRDM5_HUMAN	PR domain zinc finger protein 5 (EC 2.1.1.-) (PR domain-containing protein 5)	PRDM5 PFM2	Homo sapiens (Human)	630	FUNCTION: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells. {ECO:0000269|PubMed:15077163, ECO:0000269|PubMed:17636019, ECO:0000269|PubMed:21664999}.		cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; methylation [GO:0032259]; mitotic cell cycle [GO:0000278]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of extracellular matrix organization [GO:1903053]	nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]	nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; methylation [GO:0032259]; mitotic cell cycle [GO:0000278]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of extracellular matrix organization [GO:1903053]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15077163, ECO:0000269|PubMed:17636019}.
Q9NQX3	reviewed	GEPH_HUMAN	Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)]	GPHN GPH KIAA1385	Homo sapiens (Human)	736	FUNCTION: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}.; FUNCTION: Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:26613940}.		establishment of synaptic specificity at neuromuscular junction [GO:0007529]; gamma-aminobutyric acid receptor clustering [GO:0097112]; glycine receptor clustering [GO:0072579]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor biosynthetic process [GO:0032324]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; response to metal ion [GO:0010038]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]; postsynaptic specialization membrane [GO:0099634]; synaptic membrane [GO:0097060]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molybdopterin adenylyltransferase activity [GO:0061598]; molybdopterin cofactor binding [GO:0043546]; molybdopterin molybdotransferase activity [GO:0061599]; nitrate reductase activity [GO:0008940]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]; postsynaptic specialization membrane [GO:0099634]; synaptic membrane [GO:0097060]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molybdopterin adenylyltransferase activity [GO:0061598]; molybdopterin cofactor binding [GO:0043546]; molybdopterin molybdotransferase activity [GO:0061599]; nitrate reductase activity [GO:0008940]; establishment of synaptic specificity at neuromuscular junction [GO:0007529]; gamma-aminobutyric acid receptor clustering [GO:0097112]; glycine receptor clustering [GO:0072579]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor biosynthetic process [GO:0032324]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; response to metal ion [GO:0010038]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}; Lipid-anchor {ECO:0000269|PubMed:25025157}; Cytoplasmic side {ECO:0000305|PubMed:25025157}. Cell membrane {ECO:0000250|UniProtKB:Q03555}; Lipid-anchor {ECO:0000250|UniProtKB:Q03555}; Cytoplasmic side {ECO:0000250|UniProtKB:Q03555}. Cytoplasm, cytosol {ECO:0000269|PubMed:25025157}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q03555}. Cell projection, dendrite {ECO:0000269|PubMed:26613940}. Postsynaptic density {ECO:0000250|UniProtKB:Q8BUV3}. Note=Cytoplasmic face of glycinergic postsynaptic membranes (By similarity). Forms clusters at synapses (PubMed:25025157). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157}.
Q9NQX4	reviewed	MYO5C_HUMAN	Unconventional myosin-Vc	MYO5C	Homo sapiens (Human)	1742	FUNCTION: May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.		actin filament organization [GO:0007015]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; myosin complex [GO:0016459]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; myosin complex [GO:0016459]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; actin filament organization [GO:0007015]; vesicle transport along actin filament [GO:0030050]	
Q9NQX5	reviewed	NPDC1_HUMAN	Neural proliferation differentiation and control protein 1 (NPDC-1)	NPDC1	Homo sapiens (Human)	325	FUNCTION: Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity). {ECO:0000250}.			plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NQX7	reviewed	ITM2C_HUMAN	Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3]	ITM2C BRI3 hucep-14 NPD018 PSEC0047	Homo sapiens (Human)	267	FUNCTION: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18452648, ECO:0000269|PubMed:19366692}.		negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of neuron projection development [GO:0010977]; neuron differentiation [GO:0030182]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of neuron projection development [GO:0010977]; neuron differentiation [GO:0030182]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19114711}; Single-pass type II membrane protein {ECO:0000269|PubMed:19114711}.
Q9NQY0	reviewed	BIN3_HUMAN	Bridging integrator 3	BIN3	Homo sapiens (Human)	253	FUNCTION: Involved in cytokinesis and septation where it has a role in the localization of F-actin.		actin cortical patch localization [GO:0051666]; actin filament organization [GO:0007015]; cytoskeleton-dependent cytokinesis [GO:0061640]; division septum assembly [GO:0000917]; endocytosis [GO:0006897]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; plasma membrane tubulation [GO:0097320]; protein localization [GO:0008104]; regulation of lamellipodium assembly [GO:0010591]; skeletal muscle fiber development [GO:0048741]; unidimensional cell growth [GO:0009826]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]	cytoskeletal anchor activity [GO:0008093]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeletal anchor activity [GO:0008093]; actin cortical patch localization [GO:0051666]; actin filament organization [GO:0007015]; cytoskeleton-dependent cytokinesis [GO:0061640]; division septum assembly [GO:0000917]; endocytosis [GO:0006897]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; plasma membrane tubulation [GO:0097320]; protein localization [GO:0008104]; regulation of lamellipodium assembly [GO:0010591]; skeletal muscle fiber development [GO:0048741]; unidimensional cell growth [GO:0009826]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
Q9NQZ2	reviewed	SAS10_HUMAN	Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog)	UTP3 CRLZ1 SAS10	Homo sapiens (Human)	479	FUNCTION: Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:Q12136, ECO:0000250|UniProtKB:Q9JI13, ECO:0000269|PubMed:34516797}.		brain development [GO:0007420]; chromatin organization [GO:0006325]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; brain development [GO:0007420]; chromatin organization [GO:0006325]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
Q9NQZ3	reviewed	DAZ1_HUMAN	Deleted in azoospermia protein 1	DAZ1 DAZ SPGY	Homo sapiens (Human)	744	FUNCTION: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells. {ECO:0000269|PubMed:19865085}.	MISCELLANEOUS: DAZ genes are prone to deletions but also to duplications. In a population of infertile men, DAZ genes deletions are associated with oligozoospermia but an increased number of DAZ genes is not a significant risk factor for spermatogenic failure.; MISCELLANEOUS: The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated region of the Y chromosome, in two clusters each comprising an inverted pair of DAZ genes. They are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a DAZ protein involve all the 4 proteins.	3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	mRNA 3'-UTR binding [GO:0003730]; translation activator activity [GO:0008494]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; mRNA 3'-UTR binding [GO:0003730]; translation activator activity [GO:0008494]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11058556}. Nucleus {ECO:0000269|PubMed:11058556}. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
Q9NQZ6	reviewed	ZC4H2_HUMAN	Zinc finger C4H2 domain-containing protein (Hepatocellular carcinoma-associated antigen 127)	ZC4H2 HCA127 KIAA1166	Homo sapiens (Human)	224	FUNCTION: Plays a role in interneurons differentiation (PubMed:26056227). Involved in neuronal development and in neuromuscular junction formation. {ECO:0000269|PubMed:23623388, ECO:0000269|PubMed:26056227}.		nervous system development [GO:0007399]; neuromuscular junction development [GO:0007528]; noradrenergic neuron development [GO:0003358]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of neuron differentiation [GO:0045666]; protein monoubiquitination [GO:0006513]; regulation of transcription regulatory region DNA binding [GO:2000677]; spinal cord motor neuron differentiation [GO:0021522]	cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; metal ion binding [GO:0046872]; nervous system development [GO:0007399]; neuromuscular junction development [GO:0007528]; noradrenergic neuron development [GO:0003358]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of neuron differentiation [GO:0045666]; protein monoubiquitination [GO:0006513]; regulation of transcription regulatory region DNA binding [GO:2000677]; spinal cord motor neuron differentiation [GO:0021522]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23623388}. Nucleus {ECO:0000269|PubMed:23623388, ECO:0000269|PubMed:26056227}. Postsynaptic cell membrane {ECO:0000269|PubMed:23623388}. Note=Upon transfection into mouse primary hippocampal neurons, localizes at excitatory, but not inhibitory, postsynaptic sites.
Q9NQZ7	reviewed	ENTP7_HUMAN	Ectonucleoside triphosphate diphosphohydrolase 7 (NTPDase 7) (EC 3.6.1.15) (Lysosomal apyrase-like protein 1)	ENTPD7 LALP1	Homo sapiens (Human)	604	FUNCTION: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Preferentially hydrolyzes nucleoside 5'-triphosphates, with substrate preference for UTP > GTP > CTP. Hydrolyzes ATP and nucleoside diphosphates only to a minor extent. {ECO:0000269|PubMed:11278936}.		CTP catabolic process [GO:0006254]; GTP metabolic process [GO:0046039]; nucleobase-containing small molecule catabolic process [GO:0034656]; regulation of immune response [GO:0050776]; T-helper 17 cell differentiation [GO:0072539]; UDP catabolic process [GO:0006256]; UTP catabolic process [GO:0046052]	cytoplasmic vesicle membrane [GO:0030659]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	CTPase activity [GO:0043273]; GDP phosphatase activity [GO:0004382]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]	cytoplasmic vesicle membrane [GO:0030659]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; CTPase activity [GO:0043273]; GDP phosphatase activity [GO:0004382]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]; CTP catabolic process [GO:0006254]; GTP metabolic process [GO:0046039]; nucleobase-containing small molecule catabolic process [GO:0034656]; regulation of immune response [GO:0050776]; T-helper 17 cell differentiation [GO:0072539]; UDP catabolic process [GO:0006256]; UTP catabolic process [GO:0046052]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:11278936}; Multi-pass membrane protein {ECO:0000255}.
Q9NQZ8	reviewed	ZNF71_HUMAN	Endothelial zinc finger protein induced by tumor necrosis factor alpha (Zinc finger protein 71)	ZNF71 EZFIT	Homo sapiens (Human)	489	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NR00	reviewed	TCIM_HUMAN	Transcriptional and immune response regulator (Thyroid cancer protein 1) (TC-1)	TCIM C8orf4 TC1	Homo sapiens (Human)	106	FUNCTION: Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737). {ECO:0000250|UniProtKB:Q9D915, ECO:0000269|PubMed:15087392, ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:16730711, ECO:0000269|PubMed:17603013, ECO:0000269|PubMed:18959821, ECO:0000269|PubMed:19684084, ECO:0000269|PubMed:24941347, ECO:0000269|PubMed:25985737, ECO:0000305}.		apoptotic process [GO:0006915]; cellular response to heat [GO:0034605]; endothelial cell activation involved in immune response [GO:0002264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein kinase C activity [GO:1900020]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of hemopoiesis [GO:1903706]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	Notch binding [GO:0005112]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Notch binding [GO:0005112]; apoptotic process [GO:0006915]; cellular response to heat [GO:0034605]; endothelial cell activation involved in immune response [GO:0002264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein kinase C activity [GO:1900020]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of hemopoiesis [GO:1903706]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:25985737}. Nucleus, nucleolus {ECO:0000269|PubMed:16424001}. Nucleus speckle {ECO:0000269|PubMed:16424001}. Nucleus {ECO:0000269|PubMed:16424001}. Note=Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001). Translocates to the nucleus upon cellular stress such as H(2)O(2) (PubMed:17603013). {ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:17603013}.
Q9NR09	reviewed	BIRC6_HUMAN	Baculoviral IAP repeat-containing protein 6 (EC 2.3.2.27) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (RING-type E3 ubiquitin transferase BIRC6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON)	BIRC6 KIAA1289	Homo sapiens (Human)	4857	FUNCTION: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its targets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; labyrinthine layer development [GO:0060711]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell population proliferation [GO:0008284]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of cell population proliferation [GO:0042127]; regulation of cytokinesis [GO:0032465]; spongiotrophoblast layer development [GO:0060712]	cytosol [GO:0005829]; endosome [GO:0005768]; Flemming body [GO:0090543]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle pole [GO:0000922]; trans-Golgi network [GO:0005802]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; endosome [GO:0005768]; Flemming body [GO:0090543]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle pole [GO:0000922]; trans-Golgi network [GO:0005802]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; labyrinthine layer development [GO:0060711]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell population proliferation [GO:0008284]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of cell population proliferation [GO:0042127]; regulation of cytokinesis [GO:0032465]; spongiotrophoblast layer development [GO:0060712]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18329369}. Endosome {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18329369}. Midbody, Midbody ring {ECO:0000269|PubMed:18329369}. Note=Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369). {ECO:0000269|PubMed:18329369}.
Q9NR11	reviewed	ZN302_HUMAN	Zinc finger protein 302 (Zinc finger protein 135-like) (Zinc finger protein 140-like) (Zinc finger protein 327)	ZNF302 ZNF135L ZNF140L ZNF327	Homo sapiens (Human)	478	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NR12	reviewed	PDLI7_HUMAN	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)	PDLIM7 ENIGMA	Homo sapiens (Human)	457	FUNCTION: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}.	MISCELLANEOUS: [Isoform 2]: Did not induce bone induction. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Same activity as isoform 1 in bone nodule induction. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	actin cytoskeleton organization [GO:0030036]; cell differentiation [GO:0030154]; heart development [GO:0007507]; muscle structure development [GO:0061061]; ossification [GO:0001503]; receptor-mediated endocytosis [GO:0006898]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; actin cytoskeleton organization [GO:0030036]; cell differentiation [GO:0030154]; heart development [GO:0007507]; muscle structure development [GO:0061061]; ossification [GO:0001503]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Colocalizes with TBX4 and TBX5 to actin filaments (By similarity). {ECO:0000250}.
Q9NR16	reviewed	C163B_HUMAN	Scavenger receptor cysteine-rich type 1 protein M160 (CD163 antigen-like 1) (CD antigen CD163b)	CD163L1 CD163B M160 UNQ6434/PRO23202	Homo sapiens (Human)	1453				external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]		external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.
Q9NR19	reviewed	ACSA_HUMAN	Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acetyl-CoA synthetase 1) (AceCS1) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) (Propionate--CoA ligase) (EC 6.2.1.17)	ACSS2 ACAS2	Homo sapiens (Human)	701	FUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429). Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429). Can also utilize propionate with a much lower affinity (By similarity). {ECO:0000250|UniProtKB:Q9QXG4, ECO:0000269|PubMed:10843999, ECO:0000269|PubMed:28003429}.		acetate biosynthetic process [GO:0019413]; acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; ethanol oxidation [GO:0006069]; lipid biosynthetic process [GO:0008610]; propionate biosynthetic process [GO:0019542]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]	acetate-CoA ligase activity [GO:0003987]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; propionate-CoA ligase activity [GO:0050218]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; acetate-CoA ligase activity [GO:0003987]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; propionate-CoA ligase activity [GO:0050218]; acetate biosynthetic process [GO:0019413]; acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; ethanol oxidation [GO:0006069]; lipid biosynthetic process [GO:0008610]; propionate biosynthetic process [GO:0019542]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10843999, ECO:0000269|PubMed:28003429}.
Q9NR20	reviewed	DYRK4_HUMAN	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1)	DYRK4	Homo sapiens (Human)	520	FUNCTION: Possible non-essential role in spermiogenesis. {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: May be due to a competing acceptor splice site.; MISCELLANEOUS: [Isoform 5]: Due to an alternative splicing donor site in exon 19. Markedly reduced enzymatic activity. {ECO:0000269|PubMed:21127067}.	phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:17292540}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:21127067}. Nucleus {ECO:0000269|PubMed:21127067}.
Q9NR21	reviewed	PAR11_HUMAN	Protein mono-ADP-ribosyltransferase PARP11 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 11) (ARTD11) (Poly [ADP-ribose] polymerase 11) (PARP-11)	PARP11 C12orf6	Homo sapiens (Human)	338	FUNCTION: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). {ECO:0000250|UniProtKB:Q8CFF0, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:25673562}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell differentiation [GO:0030154]; mRNA transport [GO:0051028]; nuclear envelope organization [GO:0006998]; protein auto-ADP-ribosylation [GO:0070213]; protein transport [GO:0015031]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+- protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+- protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; cell differentiation [GO:0030154]; mRNA transport [GO:0051028]; nuclear envelope organization [GO:0006998]; protein auto-ADP-ribosylation [GO:0070213]; protein transport [GO:0015031]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:25673562}. Note=Colocalizes with NUP153 at nuclear pores. {ECO:0000269|PubMed:25673562}.
Q9NR22	reviewed	ANM8_HUMAN	Protein arginine N-methyltransferase 8 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4)	PRMT8 HRMT1L3 HRMT1L4	Homo sapiens (Human)	394	FUNCTION: S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (PubMed:18320585). {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:17925405, ECO:0000269|PubMed:18320585, ECO:0000269|PubMed:26529540, ECO:0000269|PubMed:26876602}.		peptidyl-arginine methylation [GO:0018216]; protein homooligomerization [GO:0051260]; protein methylation [GO:0006479]; regulation of protein binding [GO:0043393]	cytoplasmic side of plasma membrane [GO:0009898]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]; histone H4 methyltransferase activity [GO:0140939]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; S-adenosyl-L-methionine binding [GO:1904047]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	cytoplasmic side of plasma membrane [GO:0009898]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; histone H4 methyltransferase activity [GO:0140939]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; S-adenosyl-L-methionine binding [GO:1904047]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; peptidyl-arginine methylation [GO:0018216]; protein homooligomerization [GO:0051260]; protein methylation [GO:0006479]; regulation of protein binding [GO:0043393]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585, ECO:0000269|PubMed:26876602}; Lipid-anchor {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585, ECO:0000269|PubMed:26876602}; Cytoplasmic side {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585, ECO:0000269|PubMed:26876602}.
Q9NR23	reviewed	GDF3_HUMAN	Growth/differentiation factor 3 (GDF-3)	GDF3 UNQ222/PRO248	Homo sapiens (Human)	364	FUNCTION: Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor CRIPTO (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and CRIPTO/Cripto (PubMed:21805089). {ECO:0000250|UniProtKB:Q07104, ECO:0000269|PubMed:21805089}.	MISCELLANEOUS: In contrast to other members of this family, cannot be disulfide-linked due to an atypical cysteine knot configuration, where the fourth cysteine is missing. This fourth cysteine is involved in an inter-molecular bridge to stabilize the active form of homodimeric or heterodimeric signaling molecules. {ECO:0000305}.	endoderm development [GO:0007492]; eye development [GO:0001654]; formation of anatomical boundary [GO:0048859]; in utero embryonic development [GO:0001701]; mesoderm development [GO:0007498]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of epidermal cell differentiation [GO:0045605]; negative regulation of myoblast differentiation [GO:0045662]; notochord development [GO:0030903]; positive regulation of fat cell differentiation [GO:0045600]; primitive streak formation [GO:0090009]; regulation of cell fate commitment [GO:0010453]; response to dietary excess [GO:0002021]; skeletal system development [GO:0001501]; somite rostral/caudal axis specification [GO:0032525]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein kinase binding [GO:0019901]; endoderm development [GO:0007492]; eye development [GO:0001654]; formation of anatomical boundary [GO:0048859]; in utero embryonic development [GO:0001701]; mesoderm development [GO:0007498]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of epidermal cell differentiation [GO:0045605]; negative regulation of myoblast differentiation [GO:0045662]; notochord development [GO:0030903]; positive regulation of fat cell differentiation [GO:0045600]; primitive streak formation [GO:0090009]; regulation of cell fate commitment [GO:0010453]; response to dietary excess [GO:0002021]; skeletal system development [GO:0001501]; somite rostral/caudal axis specification [GO:0032525]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19864492, ECO:0000269|PubMed:21805089}. Cytoplasm {ECO:0000269|PubMed:19864492, ECO:0000269|PubMed:21805089}. Note=Mainly accumulated in the cytoplasm. {ECO:0000269|PubMed:21805089}.
Q9NR28	reviewed	DBLOH_HUMAN	Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]	DIABLO SMAC	Homo sapiens (Human)	239	FUNCTION: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:15200957}.; FUNCTION: [Isoform 3]: Attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. {ECO:0000269|PubMed:14523016}.; FUNCTION: [Isoform 1]: Defective in the capacity to down-regulate the XIAP/BIRC4 abundance. {ECO:0000269|PubMed:14523016}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]	CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]		CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10972280, ECO:0000269|PubMed:14523016, ECO:0000269|PubMed:28288130}. Cytoplasm, cytosol {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:28288130}. Note=Released into the cytosol in a PARL-dependent manner when cells undergo apoptosis. {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:28288130}.
Q9NR30	reviewed	DDX21_HUMAN	Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)	DDX21	Homo sapiens (Human)	783	FUNCTION: RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}.	MISCELLANEOUS: Autoantibodies against DDX21 are found in patients with watermelon stomach disease, which is characterized by prominent stripes of ectatic vascular tissue in the stomach similar to stripes on a watermelon. {ECO:0000269|PubMed:8614622}.	chromatin remodeling [GO:0006338]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of transcription by RNA polymerase I [GO:0016479]; osteoblast differentiation [GO:0001649]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of histone acetylation [GO:0035066]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; R-loop processing [GO:0062176]; response to exogenous dsRNA [GO:0043330]; rRNA processing [GO:0006364]; transcription by RNA polymerase II [GO:0006366]	B-WICH complex [GO:0110016]; chromosome [GO:0005694]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	7SK snRNA binding [GO:0097322]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase inhibitor activity [GO:0140870]; rRNA binding [GO:0019843]; snoRNA binding [GO:0030515]	B-WICH complex [GO:0110016]; chromosome [GO:0005694]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; 7SK snRNA binding [GO:0097322]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase inhibitor activity [GO:0140870]; rRNA binding [GO:0019843]; snoRNA binding [GO:0030515]; chromatin remodeling [GO:0006338]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of transcription by RNA polymerase I [GO:0016479]; osteoblast differentiation [GO:0001649]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of histone acetylation [GO:0035066]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; R-loop processing [GO:0062176]; response to exogenous dsRNA [GO:0043330]; rRNA processing [GO:0006364]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:23848194, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:8614622}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:28790157}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JIK5}. Mitochondrion {ECO:0000250|UniProtKB:Q9JIK5}. Note=Present both in nucleolus and nucleoplasm. Interaction with JUN promotes translocation from the nucleolus to the nucleoplasm (PubMed:11823437, PubMed:18180292). Interaction with WDR46 is required for localization to the nucleolus (PubMed:23848194). Colocalizes in the cytosol with DDX1, DHX36 and TICAM1. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:23848194}.
Q9NR31	reviewed	SAR1A_HUMAN	GTP-binding protein SAR1a (COPII-associated small GTPase)	SAR1A SAR1 SARA SARA1	Homo sapiens (Human)	198	FUNCTION: Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES). {ECO:0000250, ECO:0000269|PubMed:17005010}.		COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; regulation of COPII vesicle coating [GO:0003400]; vesicle organization [GO:0016050]	COPII vesicle coat [GO:0030127]; endoplasmic reticulum exit site [GO:0070971]; Golgi apparatus [GO:0005794]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	COPII vesicle coat [GO:0030127]; endoplasmic reticulum exit site [GO:0070971]; Golgi apparatus [GO:0005794]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; regulation of COPII vesicle coating [GO:0003400]; vesicle organization [GO:0016050]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}.
Q9NR33	reviewed	DPOE4_HUMAN	DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12)	POLE4	Homo sapiens (Human)	117	FUNCTION: Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). {ECO:0000250|UniProtKB:P27344, ECO:0000269|PubMed:10801849}.		DNA-templated DNA replication [GO:0006261]	ATAC complex [GO:0140672]; epsilon DNA polymerase complex [GO:0008622]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; protein heterodimerization activity [GO:0046982]	ATAC complex [GO:0140672]; epsilon DNA polymerase complex [GO:0008622]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; protein heterodimerization activity [GO:0046982]; DNA-templated DNA replication [GO:0006261]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NR34	reviewed	MA1C1_HUMAN	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (HMIC) (Mannosidase alpha class 1C member 1) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC)	MAN1C1 MAN1A3 MAN1C	Homo sapiens (Human)	630	FUNCTION: Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.		carbohydrate metabolic process [GO:0005975]; protein N-linked glycosylation [GO:0006487]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]	calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]; carbohydrate metabolic process [GO:0005975]; protein N-linked glycosylation [GO:0006487]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein.
Q9NR45	reviewed	SIAS_HUMAN	Sialic acid synthase (N-acetylneuraminate synthase) (EC 2.5.1.56) (N-acetylneuraminate-9-phosphate synthase) (EC 2.5.1.57) (N-acetylneuraminic acid phosphate synthase) (N-acetylneuraminic acid synthase)	NANS SAS	Homo sapiens (Human)	359	FUNCTION: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (PubMed:10749855, PubMed:27213289). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively (PubMed:10749855). {ECO:0000269|PubMed:10749855, ECO:0000269|PubMed:27213289}.		carbohydrate biosynthetic process [GO:0016051]; CMP-N-acetylneuraminate biosynthetic process [GO:0006055]; glycosylation [GO:0070085]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	N-acetylneuraminate synthase activity [GO:0050462]; N-acylneuraminate cytidylyltransferase activity [GO:0008781]; N-acylneuraminate-9-phosphate synthase activity [GO:0047444]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; N-acetylneuraminate synthase activity [GO:0050462]; N-acylneuraminate cytidylyltransferase activity [GO:0008781]; N-acylneuraminate-9-phosphate synthase activity [GO:0047444]; carbohydrate biosynthetic process [GO:0016051]; CMP-N-acetylneuraminate biosynthetic process [GO:0006055]; glycosylation [GO:0070085]	
Q9NR46	reviewed	SHLB2_HUMAN	Endophilin-B2 (SH3 domain-containing GRB2-like protein B2)	SH3GLB2 KIAA1848 PP578	Homo sapiens (Human)	395			membrane organization [GO:0061024]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; membrane organization [GO:0061024]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11161816}.
Q9NR48	reviewed	ASH1L_HUMAN	Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H)	ASH1L KIAA1420 KMT2H	Homo sapiens (Human)	2969	FUNCTION: Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}.		canonical NF-kappaB signal transduction [GO:0007249]; decidualization [GO:0046697]; flagellated sperm motility [GO:0030317]; histone H3-K36 dimethylation [GO:0097676]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of DNA-templated transcription [GO:0006355]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]; tarsal gland development [GO:1903699]; transcription by RNA polymerase II [GO:0006366]; uterine gland development [GO:1903709]; uterus morphogenesis [GO:0061038]	bicellular tight junction [GO:0005923]; chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; metal ion binding [GO:0046872]	bicellular tight junction [GO:0005923]; chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; metal ion binding [GO:0046872]; canonical NF-kappaB signal transduction [GO:0007249]; decidualization [GO:0046697]; flagellated sperm motility [GO:0030317]; histone H3-K36 dimethylation [GO:0097676]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of DNA-templated transcription [GO:0006355]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]; tarsal gland development [GO:1903699]; transcription by RNA polymerase II [GO:0006366]; uterine gland development [GO:1903709]; uterus morphogenesis [GO:0061038]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10860993, ECO:0000269|PubMed:25593309}. Cell junction, tight junction {ECO:0000269|PubMed:10860993}. Chromosome {ECO:0000305|PubMed:10860993}. Note=The relevance of tight junction localization is however unclear. {ECO:0000269|PubMed:10860993}.
Q9NR50	reviewed	EI2BG_HUMAN	Translation initiation factor eIF-2B subunit gamma (eIF-2B GDP-GTP exchange factor subunit gamma)	EIF2B3	Homo sapiens (Human)	452	FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.		cytoplasmic translational initiation [GO:0002183]; oligodendrocyte development [GO:0014003]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; guanyl-nucleotide exchange factor complex [GO:0032045]	translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; guanyl-nucleotide exchange factor complex [GO:0032045]; translation initiation factor activity [GO:0003743]; cytoplasmic translational initiation [GO:0002183]; oligodendrocyte development [GO:0014003]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	
Q9NR55	reviewed	BATF3_HUMAN	Basic leucine zipper transcriptional factor ATF-like 3 (B-ATF-3) (21 kDa small nuclear factor isolated from T-cells) (Jun dimerization protein p21SNFT)	BATF3 SNFT	Homo sapiens (Human)	127	FUNCTION: AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. {ECO:0000250, ECO:0000269|PubMed:10878360, ECO:0000269|PubMed:12087103, ECO:0000269|PubMed:15467742}.		dendritic cell differentiation [GO:0097028]; integrated stress response signaling [GO:0140467]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; dendritic cell differentiation [GO:0097028]; integrated stress response signaling [GO:0140467]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12087103}.
Q9NR56	reviewed	MBNL1_HUMAN	Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein)	MBNL1 EXP KIAA0428 MBNL	Homo sapiens (Human)	388	FUNCTION: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. {ECO:0000269|PubMed:10970838, ECO:0000269|PubMed:15257297, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:19470458}.		embryonic limb morphogenesis [GO:0030326]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; myoblast differentiation [GO:0045445]; nervous system development [GO:0007399]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; regulatory region RNA binding [GO:0001069]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; regulatory region RNA binding [GO:0001069]; RNA binding [GO:0003723]; embryonic limb morphogenesis [GO:0030326]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; myoblast differentiation [GO:0045445]; nervous system development [GO:0007399]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10970838, ECO:0000269|PubMed:11590133, ECO:0000269|PubMed:11929853}. Cytoplasm {ECO:0000269|PubMed:18335541}. Cytoplasmic granule {ECO:0000269|PubMed:18335541}. Note=Localized with DDX1, TIAL1 and YBX1 in stress granules upon stress (PubMed:18335541). Localized in the cytoplasm of multinucleated myotubes (PubMed:18335541). Colocalizes with nuclear foci of retained expanded-repeat transcripts in myotubes from patients affected by myotonic dystrophy (PubMed:10970838, PubMed:11590133, PubMed:11929853).
Q9NR61	reviewed	DLL4_HUMAN	Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4)	DLL4 UNQ1895/PRO4341	Homo sapiens (Human)	685	FUNCTION: Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344). {ECO:0000250|UniProtKB:Q9JI71, ECO:0000269|PubMed:11134954, ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:20616313}.		angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; blood circulation [GO:0008015]; blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac atrium morphogenesis [GO:0003209]; cardiac ventricle morphogenesis [GO:0003208]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; dorsal aorta morphogenesis [GO:0035912]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; pericardium morphogenesis [GO:0003344]; positive regulation of gene expression [GO:0010628]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of neural retina development [GO:0061074]; regulation of neurogenesis [GO:0050767]; signal transduction [GO:0007165]; T cell differentiation [GO:0030217]; ventral spinal cord interneuron fate commitment [GO:0060579]; ventricular trabecula myocardium morphogenesis [GO:0003222]; visual perception [GO:0007601]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; receptor ligand activity [GO:0048018]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; receptor ligand activity [GO:0048018]; angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; blood circulation [GO:0008015]; blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac atrium morphogenesis [GO:0003209]; cardiac ventricle morphogenesis [GO:0003208]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; dorsal aorta morphogenesis [GO:0035912]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; pericardium morphogenesis [GO:0003344]; positive regulation of gene expression [GO:0010628]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of neural retina development [GO:0061074]; regulation of neurogenesis [GO:0050767]; signal transduction [GO:0007165]; T cell differentiation [GO:0030217]; ventral spinal cord interneuron fate commitment [GO:0060579]; ventricular trabecula myocardium morphogenesis [GO:0003222]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9NR63	reviewed	CP26B_HUMAN	Cytochrome P450 26B1 (EC 1.14.13.-) (Cytochrome P450 26A2) (Cytochrome P450 retinoic acid-inactivating 2) (Cytochrome P450RAI-2) (Retinoic acid-metabolizing cytochrome)	CYP26B1 CYP26A2 P450RAI2	Homo sapiens (Human)	512	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed:10823918, PubMed:22020119). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (PubMed:10823918). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (PubMed:10823918, PubMed:22020119). Involved in the convertion of atRA to all-trans-4-oxo-RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). Shows preference for the following substrates: atRA > 9-cis-RA > 13-cis-RA (PubMed:10823918, PubMed:22020119). Plays a central role in germ cell development: acts by degrading RAs in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (PubMed:22019272). Essential for postnatal survival (By similarity). {ECO:0000250|UniProtKB:Q811W2, ECO:0000269|PubMed:10823918, ECO:0000269|PubMed:22019272, ECO:0000269|PubMed:22020119, ECO:0000305|PubMed:22020119}.; FUNCTION: Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo. {ECO:0000269|PubMed:26937021}.		bone morphogenesis [GO:0060349]; cell fate determination [GO:0001709]; cellular response to retinoic acid [GO:0071300]; cornification [GO:0070268]; embryonic limb morphogenesis [GO:0030326]; establishment of skin barrier [GO:0061436]; establishment of T cell polarity [GO:0001768]; inflammatory response [GO:0006954]; kidney development [GO:0001822]; male meiotic nuclear division [GO:0007140]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; positive regulation of gene expression [GO:0010628]; positive regulation of tongue muscle cell differentiation [GO:2001037]; proximal/distal pattern formation [GO:0009954]; regulation of T cell differentiation [GO:0045580]; response to vitamin A [GO:0033189]; retinoic acid catabolic process [GO:0034653]; retinoic acid metabolic process [GO:0042573]; retinoic acid receptor signaling pathway [GO:0048384]; spermatogenesis [GO:0007283]; sterol metabolic process [GO:0016125]; tongue morphogenesis [GO:0043587]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	all-trans retinoic acid 18-hydroxylase activity [GO:0062183]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; all-trans retinoic acid 18-hydroxylase activity [GO:0062183]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]; bone morphogenesis [GO:0060349]; cell fate determination [GO:0001709]; cellular response to retinoic acid [GO:0071300]; cornification [GO:0070268]; embryonic limb morphogenesis [GO:0030326]; establishment of skin barrier [GO:0061436]; establishment of T cell polarity [GO:0001768]; inflammatory response [GO:0006954]; kidney development [GO:0001822]; male meiotic nuclear division [GO:0007140]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; positive regulation of gene expression [GO:0010628]; positive regulation of tongue muscle cell differentiation [GO:2001037]; proximal/distal pattern formation [GO:0009954]; regulation of T cell differentiation [GO:0045580]; response to vitamin A [GO:0033189]; retinoic acid catabolic process [GO:0034653]; retinoic acid metabolic process [GO:0042573]; retinoic acid receptor signaling pathway [GO:0048384]; spermatogenesis [GO:0007283]; sterol metabolic process [GO:0016125]; tongue morphogenesis [GO:0043587]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43174}. Microsome membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43174}.
Q9NR71	reviewed	ASAH2_HUMAN	Neutral ceramidase (N-CDase) (NCDase) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (BCDase) (LCDase) (hCD) (N-acylsphingosine amidohydrolase 2) (Non-lysosomal ceramidase) [Cleaved into: Neutral ceramidase soluble form]	ASAH2 HNAC1	Homo sapiens (Human)	780	FUNCTION: Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10781606, PubMed:16229686, PubMed:26190575). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:15946935, PubMed:19345744, PubMed:24798654). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:11278489, PubMed:17475390). Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (PubMed:16061940). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity). This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (By similarity). {ECO:0000250|UniProtKB:Q9JHE3, ECO:0000269|PubMed:10781606, ECO:0000269|PubMed:11278489, ECO:0000269|PubMed:15946935, ECO:0000269|PubMed:16061940, ECO:0000269|PubMed:16229686, ECO:0000269|PubMed:17475390, ECO:0000269|PubMed:19345744, ECO:0000269|PubMed:24798654, ECO:0000269|PubMed:26190575}.		apoptotic process [GO:0006915]; cellular response to cytokine stimulus [GO:0071345]; ceramide biosynthetic process [GO:0046513]; ceramide catabolic process [GO:0046514]; ceramide metabolic process [GO:0006672]; lipid digestion [GO:0044241]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of apoptotic signaling pathway [GO:2001234]; regulation of mitotic cell cycle [GO:0007346]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670]	caveola [GO:0005901]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; ceramidase activity [GO:0102121]; N-acylsphingosine amidohydrolase activity [GO:0017040]; zinc ion binding [GO:0008270]	caveola [GO:0005901]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; ceramidase activity [GO:0102121]; N-acylsphingosine amidohydrolase activity [GO:0017040]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; cellular response to cytokine stimulus [GO:0071345]; ceramide biosynthetic process [GO:0046513]; ceramide catabolic process [GO:0046514]; ceramide metabolic process [GO:0006672]; lipid digestion [GO:0044241]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of apoptotic signaling pathway [GO:2001234]; regulation of mitotic cell cycle [GO:0007346]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670]	SUBCELLULAR LOCATION: [Neutral ceramidase]: Cell membrane {ECO:0000269|PubMed:15845354}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Membrane raft {ECO:0000250|UniProtKB:Q9JHE3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Membrane, caveola {ECO:0000250|UniProtKB:Q9JHE3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Golgi apparatus membrane {ECO:0000269|PubMed:30154232}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Mitochondrion {ECO:0000269|PubMed:10781606}. Secreted, extracellular exosome {ECO:0000269|PubMed:24798654}. Note=Enriched in exosomes upon stimulation by cytokine (PubMed:24798654). Enriched in caveolae and lipid rafts (By similarity). The localization to the mitochondrion could not be confirmed (PubMed:15845354). {ECO:0000250|UniProtKB:Q9JHE3, ECO:0000269|PubMed:15845354, ECO:0000269|PubMed:24798654}.; SUBCELLULAR LOCATION: [Neutral ceramidase soluble form]: Secreted {ECO:0000250|UniProtKB:Q91XT9}.
Q9NR80	reviewed	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1)	ARHGEF4 KIAA1112	Homo sapiens (Human)	690	FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:12598901, ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}.		filopodium assembly [GO:0046847]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytosol [GO:0005829]; ruffle membrane [GO:0032587]	guanyl-nucleotide exchange factor activity [GO:0005085]; protein domain specific binding [GO:0019904]	cytosol [GO:0005829]; ruffle membrane [GO:0032587]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein domain specific binding [GO:0019904]; filopodium assembly [GO:0046847]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Associated with membrane ruffles. {ECO:0000305}.
Q9NR81	reviewed	ARHG3_HUMAN	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN)	ARHGEF3	Homo sapiens (Human)	526	FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. {ECO:0000269|PubMed:12221096}.		positive regulation of Rho protein signal transduction [GO:0035025]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	cytosol [GO:0005829]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; guanyl-nucleotide exchange factor activity [GO:0005085]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9NR82	reviewed	KCNQ5_HUMAN	Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5)	KCNQ5	Homo sapiens (Human)	932	FUNCTION: Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:28669405}.		potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]	calyx of Held [GO:0044305]; clathrin coat [GO:0030118]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]	calyx of Held [GO:0044305]; clathrin coat [GO:0030118]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:11159685}; Multi-pass membrane protein {ECO:0000255}.
Q9NR83	reviewed	S2A4R_HUMAN	SLC2A4 regulator (GLUT4 enhancer factor) (GEF) (Huntington disease gene regulatory region-binding protein 1) (HDBP-1)	SLC2A4RG HDBP1	Homo sapiens (Human)	387	FUNCTION: Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'. {ECO:0000269|PubMed:14625278, ECO:0000269|PubMed:14630949}.		regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
Q9NR90	reviewed	DAZ3_HUMAN	Deleted in azoospermia protein 3	DAZ3	Homo sapiens (Human)	486	FUNCTION: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.	MISCELLANEOUS: The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated region of the Y chromosome, in two clusters each comprising an inverted pair of DAZ genes. They are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a DAZ protein involve all the 4 proteins.	3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	mRNA 3'-UTR binding [GO:0003730]; translation activator activity [GO:0008494]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; mRNA 3'-UTR binding [GO:0003730]; translation activator activity [GO:0008494]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11058556}. Nucleus {ECO:0000269|PubMed:11058556}. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
Q9NR96	reviewed	TLR9_HUMAN	Toll-like receptor 9 (CD antigen CD289)	TLR9 UNQ5798/PRO19605	Homo sapiens (Human)	1032	FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366). {ECO:0000250|UniProtKB:Q9EQU3, ECO:0000269|PubMed:11564765, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:23857366}.		canonical NF-kappaB signal transduction [GO:0007249]; cellular response to chloroquine [GO:1902350]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to metal ion [GO:0071248]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; detection of molecule of bacterial origin [GO:0032490]; innate immune response [GO:0045087]; maintenance of gastrointestinal epithelium [GO:0030277]; male gonad development [GO:0008584]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901895]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell activation [GO:0050871]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of intestinal epithelial cell development [GO:1905300]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of B cell differentiation [GO:0045577]; regulation of dendritic cell cytokine production [GO:0002730]; regulation of protein phosphorylation [GO:0001932]; regulation of toll-like receptor 9 signaling pathway [GO:0034163]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; early phagosome [GO:0032009]; endolysosome [GO:0036019]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	interleukin-1 receptor binding [GO:0005149]; pattern recognition receptor activity [GO:0038187]; protein homodimerization activity [GO:0042803]; siRNA binding [GO:0035197]; unmethylated CpG binding [GO:0045322]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; early phagosome [GO:0032009]; endolysosome [GO:0036019]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; interleukin-1 receptor binding [GO:0005149]; pattern recognition receptor activity [GO:0038187]; protein homodimerization activity [GO:0042803]; siRNA binding [GO:0035197]; unmethylated CpG binding [GO:0045322]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to chloroquine [GO:1902350]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to metal ion [GO:0071248]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; detection of molecule of bacterial origin [GO:0032490]; innate immune response [GO:0045087]; maintenance of gastrointestinal epithelium [GO:0030277]; male gonad development [GO:0008584]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901895]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell activation [GO:0050871]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of intestinal epithelial cell development [GO:1905300]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of B cell differentiation [GO:0045577]; regulation of dendritic cell cytokine production [GO:0002730]; regulation of protein phosphorylation [GO:0001932]; regulation of toll-like receptor 9 signaling pathway [GO:0034163]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9EQU3}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9EQU3}. Endosome {ECO:0000250|UniProtKB:Q9EQU3}. Lysosome {ECO:0000250|UniProtKB:Q9EQU3}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9EQU3}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Exit from the ER requires UNC93B1. Endolysosomal localization is required for proteolytic cleavage and subsequent activation. Intracellular localization of the active receptor may prevent from responding to self nucleic acid. {ECO:0000250|UniProtKB:Q9EQU3}.
Q9NR97	reviewed	TLR8_HUMAN	Toll-like receptor 8 (CD antigen CD288)	TLR8 UNQ249/PRO286	Homo sapiens (Human)	1041	FUNCTION: Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses (PubMed:33718825). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371, PubMed:33718825). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428). {ECO:0000269|PubMed:16737960, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:23520111, ECO:0000269|PubMed:25297876, ECO:0000269|PubMed:25599397, ECO:0000269|PubMed:26929371, ECO:0000269|PubMed:29155428, ECO:0000269|PubMed:31778653, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33718825}.		canonical NF-kappaB signal transduction [GO:0007249]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of interleukin-12 production [GO:0032695]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of type II interferon production [GO:0032729]; regulation of protein phosphorylation [GO:0001932]; response to virus [GO:0009615]; toll-like receptor 8 signaling pathway [GO:0034158]; toll-like receptor signaling pathway [GO:0002224]	endolysosome membrane [GO:0036020]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; single-stranded RNA binding [GO:0003727]	endolysosome membrane [GO:0036020]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; single-stranded RNA binding [GO:0003727]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of interleukin-12 production [GO:0032695]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of type II interferon production [GO:0032729]; regulation of protein phosphorylation [GO:0001932]; response to virus [GO:0009615]; toll-like receptor 8 signaling pathway [GO:0034158]; toll-like receptor signaling pathway [GO:0002224]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:25297876}; Single-pass type I membrane protein {ECO:0000250}. Note=Endosomal localization confers distinctive proteolytic processing. {ECO:0000269|PubMed:25297876}.
Q9NR99	reviewed	MXRA5_HUMAN	Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican)	MXRA5	Homo sapiens (Human)	2828	FUNCTION: In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. {ECO:0000269|PubMed:27599751}.		response to transforming growth factor beta [GO:0071559]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	extracellular matrix structural constituent [GO:0005201]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular matrix structural constituent [GO:0005201]; response to transforming growth factor beta [GO:0071559]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:27599751}.
Q9NRA0	reviewed	SPHK2_HUMAN	Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91)	SPHK2 SK2	Homo sapiens (Human)	654	FUNCTION: Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:19168031, PubMed:12954646). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}.		blood vessel development [GO:0001568]; brain development [GO:0007420]; cell population proliferation [GO:0008283]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; negative regulation of cell growth [GO:0030308]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell activation involved in immune response [GO:0033008]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of ATP biosynthetic process [GO:2001169]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytochrome-c oxidase activity [GO:1904959]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; sphinganine-1-phosphate biosynthetic process [GO:0006669]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670]; transcription initiation-coupled chromatin remodeling [GO:0045815]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	ATP binding [GO:0005524]; D-erythro-sphingosine kinase activity [GO:0017050]; histone binding [GO:0042393]; small GTPase binding [GO:0031267]; sphinganine kinase activity [GO:0008481]; sphingosine-1-phosphate receptor activity [GO:0038036]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; ATP binding [GO:0005524]; D-erythro-sphingosine kinase activity [GO:0017050]; histone binding [GO:0042393]; small GTPase binding [GO:0031267]; sphinganine kinase activity [GO:0008481]; sphingosine-1-phosphate receptor activity [GO:0038036]; blood vessel development [GO:0001568]; brain development [GO:0007420]; cell population proliferation [GO:0008283]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; negative regulation of cell growth [GO:0030308]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell activation involved in immune response [GO:0033008]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of ATP biosynthetic process [GO:2001169]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytochrome-c oxidase activity [GO:1904959]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; sphinganine-1-phosphate biosynthetic process [GO:0006669]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:17635916, ECO:0000269|PubMed:20197547, ECO:0000269|PubMed:29615132}. Nucleus {ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:17635916, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20197547, ECO:0000269|PubMed:29615132}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9JIA7}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9JIA7}. Note=In nucleus, located in nucleosomes where it associates with core histone proteins such as histone 3 (PubMed:19729656). In brains of patients with Alzheimer's disease, may be preferentially localized in the nucleus. Cytosolic expression decrease correlates with the density of amyloid deposits (PubMed:29615132). In apoptotic cells, colocalizes with CASP1 in cell membrane where is cleaved and released from cells in an active form (PubMed:20197547). {ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20197547, ECO:0000269|PubMed:29615132}.; SUBCELLULAR LOCATION: [Isoform 2]: Lysosome membrane {ECO:0000269|PubMed:17897319}.
Q9NRA1	reviewed	PDGFC_HUMAN	Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)]	PDGFC SCDGF UNQ174/PRO200	Homo sapiens (Human)	345	FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. {ECO:0000269|PubMed:10806482, ECO:0000269|PubMed:10858496, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11854040, ECO:0000269|PubMed:12032822, ECO:0000269|PubMed:15061151, ECO:0000269|PubMed:15372073, ECO:0000269|PubMed:15389578, ECO:0000269|PubMed:15728360, ECO:0000269|PubMed:15911618, ECO:0000269|PubMed:16439802, ECO:0000269|PubMed:18055825}.	MISCELLANEOUS: A lower molecular weight form (around 43 kDa) is present in patients with papillary thyroid carcinoma.	animal organ morphogenesis [GO:0009887]; bone development [GO:0060348]; cellular response to amino acid stimulus [GO:0071230]; central nervous system development [GO:0007417]; digestive tract development [GO:0048565]; fibroblast proliferation [GO:0048144]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein autophosphorylation [GO:0031954]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]	cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	growth factor activity [GO:0008083]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]	cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; growth factor activity [GO:0008083]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; animal organ morphogenesis [GO:0009887]; bone development [GO:0060348]; cellular response to amino acid stimulus [GO:0071230]; central nervous system development [GO:0007417]; digestive tract development [GO:0048565]; fibroblast proliferation [GO:0048144]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of protein autophosphorylation [GO:0031954]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16443219}. Secreted {ECO:0000269|PubMed:10806482, ECO:0000269|PubMed:10858496, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:15061151, ECO:0000269|PubMed:15372073, ECO:0000269|PubMed:15911618}. Nucleus {ECO:0000269|PubMed:16443219}. Cytoplasmic granule {ECO:0000269|PubMed:15061151}. Cell membrane {ECO:0000269|PubMed:16443219}. Note=Sumoylated form is predominant in the nucleus (PubMed:15247255). Stored in alpha granules in platelets (PubMed:15061151). {ECO:0000269|PubMed:16443219}.
Q9NRA2	reviewed	S17A5_HUMAN	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)	SLC17A5	Homo sapiens (Human)	495	FUNCTION: Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport (PubMed:15510212, PubMed:21781115, PubMed:22778404, PubMed:23889254). Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system (PubMed:15510212, PubMed:21781115, PubMed:22778404, PubMed:23889254) (By similarity). Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva (PubMed:22778404). Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release (PubMed:21781115, PubMed:22778404, PubMed:23889254) (By similarity). {ECO:0000250|UniProtKB:Q5Q0U0, ECO:0000250|UniProtKB:Q8BN82, ECO:0000269|PubMed:15510212, ECO:0000269|PubMed:21781115, ECO:0000269|PubMed:22778404, ECO:0000269|PubMed:23889254}.; FUNCTION: Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties. {ECO:0000250|UniProtKB:Q9MZD1}.		amino acid transport [GO:0006865]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; response to bacterium [GO:0009617]; sialic acid transport [GO:0015739]	basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	carbohydrate:proton symporter activity [GO:0005351]; D-glucuronate transmembrane transporter activity [GO:0042880]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]; transmembrane transporter activity [GO:0022857]	basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; carbohydrate:proton symporter activity [GO:0005351]; D-glucuronate transmembrane transporter activity [GO:0042880]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; response to bacterium [GO:0009617]; sialic acid transport [GO:0015739]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:22778404}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:21781115}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:15510212, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:22778404}; Multi-pass membrane protein {ECO:0000255}.
Q9NRA8	reviewed	4ET_HUMAN	Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1)	EIF4ENIF1	Homo sapiens (Human)	985	FUNCTION: EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}.		miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA stabilization [GO:0048255]; negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0106289]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; neuron differentiation [GO:0030182]; P-body assembly [GO:0033962]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; protein import into nucleus [GO:0006606]; stem cell population maintenance [GO:0019827]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]; PML body [GO:0016605]	kinase binding [GO:0019900]; mRNA binding [GO:0003729]; nuclear export signal receptor activity [GO:0005049]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]; PML body [GO:0016605]; kinase binding [GO:0019900]; mRNA binding [GO:0003729]; nuclear export signal receptor activity [GO:0005049]; RNA binding [GO:0003723]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA stabilization [GO:0048255]; negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0106289]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; neuron differentiation [GO:0030182]; P-body assembly [GO:0033962]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; protein import into nucleus [GO:0006606]; stem cell population maintenance [GO:0019827]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:23991149, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:32354837}. Cytoplasm {ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:22090346, ECO:0000269|PubMed:28216671}. Nucleus {ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:22090346, ECO:0000269|PubMed:28216671}. Nucleus, PML body {ECO:0000269|PubMed:22090346}. Nucleus speckle {ECO:0000269|PubMed:22090346}. Note=Predominantly cytoplasmic (PubMed:10856257). Mainly localizes to processing bodies (P-bodies) (PubMed:16157702). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:10856257). Localization to nuclear foci and speckles requires active transcription (PubMed:22090346). {ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22090346}.
Q9NRB3	reviewed	CHSTC_HUMAN	Carbohydrate sulfotransferase 12 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 2) (Chondroitin 4-sulfotransferase 2) (C4ST-2) (C4ST2) (Sulfotransferase Hlo)	CHST12 UNQ500/PRO1017	Homo sapiens (Human)	414	FUNCTION: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.		chondroitin sulfate biosynthetic process [GO:0030206]; dermatan sulfate biosynthetic process [GO:0030208]; proteoglycan biosynthetic process [GO:0030166]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; chondroitin 4-sulfotransferase activity [GO:0047756]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; chondroitin 4-sulfotransferase activity [GO:0047756]; sulfotransferase activity [GO:0008146]; chondroitin sulfate biosynthetic process [GO:0030206]; dermatan sulfate biosynthetic process [GO:0030208]; proteoglycan biosynthetic process [GO:0030166]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9NRC1	reviewed	ST7_HUMAN	Suppressor of tumorigenicity 7 protein (Protein FAM4A1) (Protein HELG)	ST7 FAM4A1 HELG RAY1	Homo sapiens (Human)	585	FUNCTION: May act as a tumor suppressor. {ECO:0000269|PubMed:16474848}.		extracellular matrix organization [GO:0030198]; regulation of cell differentiation [GO:0045595]	membrane [GO:0016020]		membrane [GO:0016020]; extracellular matrix organization [GO:0030198]; regulation of cell differentiation [GO:0045595]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NRC6	reviewed	SPTN5_HUMAN	Spectrin beta chain, non-erythrocytic 5 (Beta-V spectrin)	SPTBN5 BSPECV HUBSPECV HUSPECV	Homo sapiens (Human)	3674			actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; Golgi organization [GO:0007030]; lysosomal transport [GO:0007041]	apical cortex [GO:0045179]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; photoreceptor connecting cilium [GO:0032391]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; spectrin [GO:0008091]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; myosin tail binding [GO:0032029]; opsin binding [GO:0002046]; protein self-association [GO:0043621]; spectrin binding [GO:0030507]	apical cortex [GO:0045179]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; photoreceptor connecting cilium [GO:0032391]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; spectrin [GO:0008091]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; myosin tail binding [GO:0032029]; opsin binding [GO:0002046]; protein self-association [GO:0043621]; spectrin binding [GO:0030507]; actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; Golgi organization [GO:0007030]; lysosomal transport [GO:0007041]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Detected prominently in the outer segments of photoreceptor rods and cones and in the basolateral membrane and cytosol of gastric epithelial cells.
Q9NRC8	reviewed	SIR7_HUMAN	NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)	SIRT7 SIR2L7	Homo sapiens (Human)	400	FUNCTION: NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase, deglutarylase and dedecanoylase), depending on the context (PubMed:22722849, PubMed:26907567, PubMed:30653310, PubMed:31542297, PubMed:35939806). Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac) (PubMed:22722849, PubMed:30420520, PubMed:35939806). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression (PubMed:22722849, PubMed:30653310). H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts as a transcription repressor (PubMed:22722849). Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells (PubMed:22722849). Also able to mediate deacetylation of histone H3 at 'Lys-36' (H3K36Ac) in the context of nucleosomes (PubMed:30653310). Also mediates deacetylation of non-histone proteins, such as ATM, CDK9, DDX21, DDB1, FBL, FKBP5/FKBP51, GABPB1, RAN, RRP9/U3-55K and POLR1E/PAF53 (PubMed:24207024, PubMed:26867678, PubMed:28147277, PubMed:28886238, PubMed:28426094, PubMed:30540930, PubMed:31075303, PubMed:30944854, PubMed:28790157). Enriched in nucleolus where it stimulates transcription activity of the RNA polymerase I complex (PubMed:16618798, PubMed:19174463, PubMed:24207024). Acts by mediating the deacetylation of the RNA polymerase I subunit POLR1E/PAF53, thereby promoting the association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:16618798, PubMed:19174463, PubMed:24207024). In response to metabolic stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased RNA polymerase I transcription (PubMed:24207024). Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis (PubMed:19174463). Promotes pre-ribosomal RNA (pre-rRNA) cleavage at the 5'-terminal processing site by mediating deacetylation of RRP9/U3-55K, a core subunit of the U3 snoRNP complex (PubMed:26867678). Mediates 'Lys-37' deacetylation of Ran, thereby regulating the nuclear export of NF-kappa-B subunit RELA/p65 (PubMed:31075303). Acts as a regulator of DNA damage repair by mediating deacetylation of ATM during the late stages of DNA damage response, promoting ATM dephosphorylation and deactivation (PubMed:30944854). Suppresses the activity of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes by mediating deacetylation of DDB1, which prevents the interaction between DDB1 and CUL4 (CUL4A or CUL4B) (PubMed:28886238). Activates RNA polymerase II transcription by mediating deacetylation of CDK9, thereby promoting 'Ser-2' phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (PubMed:28426094). Deacetylates FBL, promoting histone-glutamine methyltransferase activity of FBL (PubMed:30540930). Acts as a regulator of mitochondrial function by catalyzing deacetylation of GABPB1 (By similarity). Regulates Akt/AKT1 activity by mediating deacetylation of FKBP5/FKBP51 (PubMed:28147277). Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability by mediating deacetylation and subsequent activation of DDX21, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). In addition to protein deacetylase activity, also acts as protein-lysine deacylase (PubMed:27436229, PubMed:27997115, PubMed:31542297). Acts as a protein depropionylase by mediating depropionylation of Osterix (SP7), thereby regulating bone formation by osteoblasts (By similarity). Acts as a histone deglutarylase by mediating deglutarylation of histone H4 on 'Lys-91' (H4K91glu); a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297). Acts as a histone desuccinylase: in response to DNA damage, recruited to DNA double-strand breaks (DSBs) and catalyzes desuccinylation of histone H3 on 'Lys-122' (H3K122succ), thereby promoting chromatin condensation and DSB repair (PubMed:27436229). Also promotes DSB repair by promoting H3K18Ac deacetylation, regulating non-homologous end joining (NHEJ) (By similarity). Along with its role in DNA repair, required for chromosome synapsis during prophase I of female meiosis by catalyzing H3K18Ac deacetylation (By similarity). Involved in transcriptional repression of LINE-1 retrotransposon via H3K18Ac deacetylation, and promotes their association with the nuclear lamina (PubMed:31226208). Required to stabilize ribosomal DNA (rDNA) heterochromatin and prevent cellular senescence induced by rDNA instability (PubMed:29728458). Acts as a negative regulator of SIRT1 by preventing autodeacetylation of SIRT1, restricting SIRT1 deacetylase activity (By similarity). {ECO:0000250|UniProtKB:Q8BKJ9, ECO:0000269|PubMed:16618798, ECO:0000269|PubMed:19174463, ECO:0000269|PubMed:22722849, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:26867678, ECO:0000269|PubMed:26907567, ECO:0000269|PubMed:27436229, ECO:0000269|PubMed:27997115, ECO:0000269|PubMed:28147277, ECO:0000269|PubMed:28426094, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:29728458, ECO:0000269|PubMed:30420520, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:30653310, ECO:0000269|PubMed:30944854, ECO:0000269|PubMed:31075303, ECO:0000269|PubMed:31226208, ECO:0000269|PubMed:31542297, ECO:0000269|PubMed:35939806}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; homologous chromosome pairing at meiosis [GO:0007129]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription involved in exit from mitosis [GO:0007072]; protein deacetylation [GO:0006476]; protein deglutarylation [GO:0061698]; protein depropionylation [GO:0106230]; R-loop processing [GO:0062176]; regulation of DNA repair [GO:0006282]; regulation of mitochondrion organization [GO:0010821]; regulation of protein export from nucleus [GO:0046825]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901836]; retrotransposon silencing [GO:0010526]; rRNA transcription [GO:0009303]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleolus organizer region [GO:0005731]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; NAD+ binding [GO:0070403]; NAD-dependent histone H3K18 deacetylase activity [GO:0097372]; NAD-dependent protein deacetylase activity [GO:0034979]; protein methyltransferase activity [GO:0008276]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-propionyllysine depropionylase activity [GO:0106231]; protein-succinyllysine desuccinylase activity [GO:0036055]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleolus organizer region [GO:0005731]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; NAD+ binding [GO:0070403]; NAD-dependent histone H3K18 deacetylase activity [GO:0097372]; NAD-dependent protein deacetylase activity [GO:0034979]; protein methyltransferase activity [GO:0008276]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-propionyllysine depropionylase activity [GO:0106231]; protein-succinyllysine desuccinylase activity [GO:0036055]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; homologous chromosome pairing at meiosis [GO:0007129]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription involved in exit from mitosis [GO:0007072]; protein deacetylation [GO:0006476]; protein deglutarylation [GO:0061698]; protein depropionylation [GO:0106230]; R-loop processing [GO:0062176]; regulation of DNA repair [GO:0006282]; regulation of mitochondrion organization [GO:0010821]; regulation of protein export from nucleus [GO:0046825]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901836]; retrotransposon silencing [GO:0010526]; rRNA transcription [GO:0009303]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:19174463, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:28426094, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:30420520}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:31075303}. Chromosome {ECO:0000269|PubMed:27436229, ECO:0000269|PubMed:31226208}. Cytoplasm {ECO:0000269|PubMed:11953824}. Note=Mainly localizes in the nucleolus and nucleoplasm (PubMed:24207024, PubMed:28886238, PubMed:28790157, PubMed:31075303). Associated with rDNA promoter and transcribed region (PubMed:16079181, PubMed:19174463). Associated with nucleolar organizer regions during mitosis (PubMed:16079181, PubMed:19174463). In response to stress, released from nucleolus to nucleoplasm (PubMed:24207024). Associated with chromatin (PubMed:22722849). In response to DNA damage, recruited to DNA double-strand breaks (DSBs) sites (PubMed:27436229) (Probable). Located close to the nuclear membrane when in the cytoplasm (PubMed:11953824). {ECO:0000269|PubMed:11953824, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:19174463, ECO:0000269|PubMed:22722849, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:27436229, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:31075303, ECO:0000305|PubMed:30944854}.
Q9NRD1	reviewed	FBX6_HUMAN	F-box only protein 6 (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2)	FBXO6 FBG2 FBS2 FBX6	Homo sapiens (Human)	293	FUNCTION: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication. {ECO:0000269|PubMed:18203720, ECO:0000269|PubMed:19716789}.		DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; glycoprotein catabolic process [GO:0006516]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; response to unfolded protein [GO:0006986]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum quality control compartment [GO:0044322]; SCF ubiquitin ligase complex [GO:0019005]	carbohydrate binding [GO:0030246]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum quality control compartment [GO:0044322]; SCF ubiquitin ligase complex [GO:0019005]; carbohydrate binding [GO:0030246]; ubiquitin protein ligase activity [GO:0061630]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; glycoprotein catabolic process [GO:0006516]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; response to unfolded protein [GO:0006986]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19716789}.
Q9NRD5	reviewed	PICK1_HUMAN	PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein)	PICK1 PRKCABP	Homo sapiens (Human)	415	FUNCTION: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. {ECO:0000269|PubMed:20403402}.		cellular response to decreased oxygen levels [GO:0036294]; cellular response to glucose starvation [GO:0042149]; dendritic spine maintenance [GO:0097062]; dendritic spine organization [GO:0097061]; genomic imprinting [GO:0071514]; glial cell development [GO:0021782]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; monoamine transport [GO:0015844]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; neuronal ion channel clustering [GO:0045161]; positive regulation of receptor internalization [GO:0002092]; post-fertilization epigenetic regulation of gene expression [GO:0043045]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein phosphorylation [GO:0006468]; receptor clustering [GO:0043113]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of insulin secretion [GO:0050796]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic early endosome [GO:0098842]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]	actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; G protein-coupled receptor binding [GO:0001664]; identical protein binding [GO:0042802]; membrane curvature sensor activity [GO:0140090]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic early endosome [GO:0098842]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; G protein-coupled receptor binding [GO:0001664]; identical protein binding [GO:0042802]; membrane curvature sensor activity [GO:0140090]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; signaling receptor binding [GO:0005102]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to glucose starvation [GO:0042149]; dendritic spine maintenance [GO:0097062]; dendritic spine organization [GO:0097061]; genomic imprinting [GO:0071514]; glial cell development [GO:0021782]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; monoamine transport [GO:0015844]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; neuronal ion channel clustering [GO:0045161]; positive regulation of receptor internalization [GO:0002092]; post-fertilization epigenetic regulation of gene expression [GO:0043045]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein phosphorylation [GO:0006468]; receptor clustering [GO:0043113]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of insulin secretion [GO:0050796]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Also membrane-associated, present at excitatory synapses. {ECO:0000250}.
Q9NRD8	reviewed	DUOX2_HUMAN	Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase p138-tox) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Thyroid oxidase 2) (p138 thyroid oxidase)	DUOX2 LNOX2 THOX2	Homo sapiens (Human)	1548	FUNCTION: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:12824283}.		cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide biosynthetic process [GO:0050665]; hydrogen peroxide catabolic process [GO:0042744]; positive regulation of cell motility [GO:2000147]; positive regulation of wound healing [GO:0090303]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; response to virus [GO:0009615]; superoxide anion generation [GO:0042554]; thyroid hormone generation [GO:0006590]	anchoring junction [GO:0070161]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADH oxidase H202-forming activity [GO:0106293]; NADPH oxidase H202-forming activity [GO:0106294]; peroxidase activity [GO:0004601]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]	anchoring junction [GO:0070161]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADH oxidase H202-forming activity [GO:0106293]; NADPH oxidase H202-forming activity [GO:0106294]; peroxidase activity [GO:0004601]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide biosynthetic process [GO:0050665]; hydrogen peroxide catabolic process [GO:0042744]; positive regulation of cell motility [GO:2000147]; positive regulation of wound healing [GO:0090303]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; response to virus [GO:0009615]; superoxide anion generation [GO:0042554]; thyroid hormone generation [GO:0006590]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:15591162, ECO:0000269|PubMed:26301257}; Multi-pass membrane protein {ECO:0000269|PubMed:15591162}. Cell junction {ECO:0000269|PubMed:26301257}. Note=Localizes to the apical membrane of epithelial cells. Localizes on internal membrane structures under resting conditions, translocates to the plasma membrane and cell-cell junctions upon challenge with enteric pathogens, such as Escherichia coli. {ECO:0000269|PubMed:26301257}.
Q9NRD9	reviewed	DUOX1_HUMAN	Dual oxidase 1 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 1) (Long NOX 1) (NADPH thyroid oxidase 1) (Thyroid oxidase 1)	DUOX1 DUOX LNOX1 THOX1	Homo sapiens (Human)	1551	FUNCTION: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283}.		cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide biosynthetic process [GO:0050665]; hydrogen peroxide catabolic process [GO:0042744]; positive regulation of cell motility [GO:2000147]; positive regulation of wound healing [GO:0090303]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; superoxide anion generation [GO:0042554]; thyroid hormone generation [GO:0006590]	apical plasma membrane [GO:0016324]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADH oxidase H202-forming activity [GO:0106293]; NADP binding [GO:0050661]; NADPH oxidase H202-forming activity [GO:0106294]; peroxidase activity [GO:0004601]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]	apical plasma membrane [GO:0016324]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADH oxidase H202-forming activity [GO:0106293]; NADP binding [GO:0050661]; NADPH oxidase H202-forming activity [GO:0106294]; peroxidase activity [GO:0004601]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide biosynthetic process [GO:0050665]; hydrogen peroxide catabolic process [GO:0042744]; positive regulation of cell motility [GO:2000147]; positive regulation of wound healing [GO:0090303]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; superoxide anion generation [GO:0042554]; thyroid hormone generation [GO:0006590]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:15210697}; Multi-pass membrane protein {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:15210697}. Note=Localizes to the apical membrane of epithelial cells.
Q9NRE1	reviewed	MMP26_HUMAN	Matrix metalloproteinase-26 (MMP-26) (EC 3.4.24.-) (Endometase) (Matrilysin-2)	MMP26	Homo sapiens (Human)	261	FUNCTION: May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.		collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; negative regulation of inflammatory response [GO:0050728]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; negative regulation of inflammatory response [GO:0050728]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q9NRE2	reviewed	TSH2_HUMAN	Teashirt homolog 2 (Ovarian cancer-related protein 10-2) (OVC10-2) (Zinc finger protein 218)	TSHZ2 C20orf17 TSH2 ZNF218	Homo sapiens (Human)	1034	FUNCTION: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NRF2	reviewed	SH2B1_HUMAN	SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)	SH2B1 KIAA1299 SH2B	Homo sapiens (Human)	756	FUNCTION: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:11827956, ECO:0000269|PubMed:14565960, ECO:0000269|PubMed:15767667, ECO:0000269|PubMed:16569669, ECO:0000269|PubMed:17471236, ECO:0000269|PubMed:9694882, ECO:0000269|PubMed:9742218}.		intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of DNA biosynthetic process [GO:2000278]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of DNA biosynthetic process [GO:2000278]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
Q9NRF8	reviewed	PYRG2_HUMAN	CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2)	CTPS2	Homo sapiens (Human)	586	FUNCTION: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. {ECO:0000269|PubMed:10899599, ECO:0000269|PubMed:16179339}.		'de novo' CTP biosynthetic process [GO:0044210]; CTP biosynthetic process [GO:0006241]; glutamine metabolic process [GO:0006541]; pyrimidine nucleobase biosynthetic process [GO:0019856]; pyrimidine nucleotide metabolic process [GO:0006220]	cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802]	cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802]; 'de novo' CTP biosynthetic process [GO:0044210]; CTP biosynthetic process [GO:0006241]; glutamine metabolic process [GO:0006541]; pyrimidine nucleobase biosynthetic process [GO:0019856]; pyrimidine nucleotide metabolic process [GO:0006220]	
Q9NRF9	reviewed	DPOE3_HUMAN	DNA polymerase epsilon subunit 3 (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17)	POLE3 CHRAC17	Homo sapiens (Human)	147	FUNCTION: Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (PubMed:10801849). Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371). {ECO:0000250|UniProtKB:Q04603, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:14759371}.		chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; heterochromatin formation [GO:0031507]; leading strand elongation [GO:0006272]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]; regulation of DNA replication [GO:0006275]	ATAC complex [GO:0140672]; CHRAC [GO:0008623]; epsilon DNA polymerase complex [GO:0008622]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	chromatin DNA binding [GO:0031490]; DNA-directed DNA polymerase activity [GO:0003887]; protein heterodimerization activity [GO:0046982]	ATAC complex [GO:0140672]; CHRAC [GO:0008623]; epsilon DNA polymerase complex [GO:0008622]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; chromatin DNA binding [GO:0031490]; DNA-directed DNA polymerase activity [GO:0003887]; protein heterodimerization activity [GO:0046982]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; heterochromatin formation [GO:0031507]; leading strand elongation [GO:0006272]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]; regulation of DNA replication [GO:0006275]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NRG0	reviewed	CHRC1_HUMAN	Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15)	CHRAC1 CHRAC15	Homo sapiens (Human)	131	FUNCTION: Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371). {ECO:0000269|PubMed:14759371}.		chromatin remodeling [GO:0006338]; DNA-templated DNA replication [GO:0006261]; nucleosome assembly [GO:0006334]; regulation of DNA replication [GO:0006275]	CHRAC [GO:0008623]; epsilon DNA polymerase complex [GO:0008622]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; protein heterodimerization activity [GO:0046982]	CHRAC [GO:0008623]; epsilon DNA polymerase complex [GO:0008622]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; protein heterodimerization activity [GO:0046982]; chromatin remodeling [GO:0006338]; DNA-templated DNA replication [GO:0006261]; nucleosome assembly [GO:0006334]; regulation of DNA replication [GO:0006275]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NRG1	reviewed	PRDC1_HUMAN	Phosphoribosyltransferase domain-containing protein 1	PRTFDC1 HHGP	Homo sapiens (Human)	225	FUNCTION: Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.		purine ribonucleoside salvage [GO:0006166]	cytosol [GO:0005829]	magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; protein homodimerization activity [GO:0042803]; purine ribonucleoside salvage [GO:0006166]	
Q9NRG4	reviewed	SMYD2_HUMAN	N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (HSKM-B) (Histone methyltransferase SMYD2) (EC 2.1.1.354) (Lysine N-methyltransferase 3C) (SET and MYND domain-containing protein 2)	SMYD2 KMT3C	Homo sapiens (Human)	433	FUNCTION: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. {ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:18065756, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21782458, ECO:0000269|PubMed:21880715}.		heart development [GO:0007507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of signal transduction by p53 class mediator [GO:1901796]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 trimethyltransferase activity [GO:0140999]; lysine N-methyltransferase activity [GO:0016278]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; RNA polymerase II complex binding [GO:0000993]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 trimethyltransferase activity [GO:0140999]; lysine N-methyltransferase activity [GO:0016278]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; RNA polymerase II complex binding [GO:0000993]; heart development [GO:0007507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of signal transduction by p53 class mediator [GO:1901796]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.
Q9NRG9	reviewed	AAAS_HUMAN	Aladin (Adracalin)	AAAS ADRACALA GL003	Homo sapiens (Human)	546	FUNCTION: Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606). {ECO:0000269|PubMed:11062474, ECO:0000269|PubMed:11159947, ECO:0000269|PubMed:16022285, ECO:0000269|PubMed:26246606}.	MISCELLANEOUS: [Isoform 2]: Ubiquitously expressed. {ECO:0000305}.	fertilization [GO:0009566]; learning [GO:0007612]; microtubule bundle formation [GO:0001578]; mitotic spindle assembly [GO:0090307]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of nucleocytoplasmic transport [GO:0046822]	centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]		centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; fertilization [GO:0009566]; learning [GO:0007612]; microtubule bundle formation [GO:0001578]; mitotic spindle assembly [GO:0090307]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of nucleocytoplasmic transport [GO:0046822]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:19782045}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:26246606}. Nucleus envelope {ECO:0000269|PubMed:27754849}. Note=In metaphase cells localizes within the spindle with some accumulation around spindle poles, with the highest concentration between the centrosome and metaphase plate (PubMed:26246606). The localization to the spindle is microtubule-mediated (PubMed:26246606). {ECO:0000269|PubMed:26246606}.
Q9NRH2	reviewed	SNRK_HUMAN	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase)	SNRK KIAA0096 SNFRK	Homo sapiens (Human)	765	FUNCTION: May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. {ECO:0000250|UniProtKB:Q63553, ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:15733851}.		intracellular signal transduction [GO:0035556]; myeloid cell differentiation [GO:0030099]; protein phosphorylation [GO:0006468]	nucleus [GO:0005634]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; myeloid cell differentiation [GO:0030099]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9NRH3	reviewed	TBG2_HUMAN	Tubulin gamma-2 chain (Gamma-2-tubulin)	TUBG2	Homo sapiens (Human)	451	FUNCTION: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity). {ECO:0000250}.		cytoplasmic microtubule organization [GO:0031122]; meiotic spindle organization [GO:0000212]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; spindle [GO:0005819]; spindle microtubule [GO:0005876]	GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; cytoplasmic microtubule organization [GO:0031122]; meiotic spindle organization [GO:0000212]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000305}.
Q9NRI5	reviewed	DISC1_HUMAN	Disrupted in schizophrenia 1 protein	DISC1 KIAA0457	Homo sapiens (Human)	854	FUNCTION: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19502360, PubMed:19303846). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030). {ECO:0000250|UniProtKB:Q811T9, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:19303846, ECO:0000269|PubMed:19502360}.	MISCELLANEOUS: [Isoform 1]: Non-canonical donor and acceptor splice sites for the last 2 exons. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2]: Non-canonical donor and acceptor splice sites for the last 2 exons. {ECO:0000305}.	canonical Wnt signaling pathway [GO:0060070]; cell proliferation in forebrain [GO:0021846]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; mitochondrial calcium ion homeostasis [GO:0051560]; negative regulation of protein binding [GO:0032091]; neuron cellular homeostasis [GO:0070050]; neuron migration [GO:0001764]; non-motile cilium assembly [GO:1905515]; positive regulation of axon extension [GO:0045773]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of Wnt signaling pathway [GO:0030177]; protein localization to centrosome [GO:0071539]; pyramidal neuron migration to cerebral cortex [GO:0021852]; regulation of dendritic spine development [GO:0060998]; regulation of postsynapse organization [GO:0099175]; regulation of synapse maturation [GO:0090128]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to electrical stimulus [GO:0051602]; TOR signaling [GO:0031929]; ubiquitin-dependent protein catabolic process [GO:0006511]	cell body [GO:0044297]; central region of growth cone [GO:0090724]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytosol [GO:0005829]; dynein complex [GO:0030286]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intermediate filament cytoskeleton [GO:0045111]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; synaptic vesicle [GO:0008021]	identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]	cell body [GO:0044297]; central region of growth cone [GO:0090724]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytosol [GO:0005829]; dynein complex [GO:0030286]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intermediate filament cytoskeleton [GO:0045111]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; synaptic vesicle [GO:0008021]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; canonical Wnt signaling pathway [GO:0060070]; cell proliferation in forebrain [GO:0021846]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; mitochondrial calcium ion homeostasis [GO:0051560]; negative regulation of protein binding [GO:0032091]; neuron cellular homeostasis [GO:0070050]; neuron migration [GO:0001764]; non-motile cilium assembly [GO:1905515]; positive regulation of axon extension [GO:0045773]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of Wnt signaling pathway [GO:0030177]; protein localization to centrosome [GO:0071539]; pyramidal neuron migration to cerebral cortex [GO:0021852]; regulation of dendritic spine development [GO:0060998]; regulation of postsynapse organization [GO:0099175]; regulation of synapse maturation [GO:0090128]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to electrical stimulus [GO:0051602]; TOR signaling [GO:0031929]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12506198, ECO:0000269|PubMed:15797709}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14962739, ECO:0000269|PubMed:15797709}. Mitochondrion {ECO:0000269|PubMed:12506198, ECO:0000269|PubMed:15797709}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12812986, ECO:0000269|PubMed:18955030}. Postsynaptic density {ECO:0000250|UniProtKB:Q811T9}. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria (PubMed:12506198, PubMed:15797709). Colocalizes with PCNT at the centrosome (PubMed:18955030). {ECO:0000250|UniProtKB:Q811T9, ECO:0000269|PubMed:12506198, ECO:0000269|PubMed:15797709, ECO:0000269|PubMed:18955030}.
Q9NRJ3	reviewed	CCL28_HUMAN	C-C motif chemokine 28 (Mucosae-associated epithelial chemokine) (MEC) (Protein CCK1) (Small-inducible cytokine A28)	CCL28 SCYA28	Homo sapiens (Human)	127	FUNCTION: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.		cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; immune response [GO:0006955]; negative regulation of leukocyte tethering or rolling [GO:1903237]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to nutrient [GO:0007584]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	chemokine activity [GO:0008009]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; chemokine activity [GO:0008009]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; immune response [GO:0006955]; negative regulation of leukocyte tethering or rolling [GO:1903237]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to nutrient [GO:0007584]	SUBCELLULAR LOCATION: Secreted.
Q9NRJ4	reviewed	TULP4_HUMAN	Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4)	TULP4 KIAA1397 TUBL4 TUSP	Homo sapiens (Human)	1543	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm.
Q9NRJ7	reviewed	PCDBG_HUMAN	Protocadherin beta-16 (PCDH-beta-16) (Protocadherin-3X)	PCDHB16 KIAA1621 PCDH3X	Homo sapiens (Human)	776	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9NRK6	reviewed	ABCBA_HUMAN	ATP-binding cassette sub-family B member 10, mitochondrial (ABC-mitochondrial erythroid protein) (ABC-me protein) (ATP-binding cassette transporter 10) (ABC transporter 10 protein) (Mitochondrial ATP-binding cassette 2) (M-ABC2)	ABCB10	Homo sapiens (Human)	738	FUNCTION: Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner (PubMed:33253225). May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria (PubMed:33253225). Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). In turn participates in hemoglobin synthesis and also protects against oxidative stress (PubMed:28808058, PubMed:22085049). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685). {ECO:0000269|PubMed:22085049, ECO:0000269|PubMed:28315685, ECO:0000269|PubMed:28808058, ECO:0000269|PubMed:33253225}.		erythrocyte development [GO:0048821]; heme biosynthetic process [GO:0006783]; mitochondrial transport [GO:0006839]; mitochondrial unfolded protein response [GO:0034514]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of hemoglobin biosynthetic process [GO:0046985]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein homodimerization activity [GO:0042803]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein homodimerization activity [GO:0042803]; erythrocyte development [GO:0048821]; heme biosynthetic process [GO:0006783]; mitochondrial transport [GO:0006839]; mitochondrial unfolded protein response [GO:0034514]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of hemoglobin biosynthetic process [GO:0046985]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9JI39}; Multi-pass membrane protein {ECO:0000255}.
Q9NRL2	reviewed	BAZ1A_HUMAN	Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1)	BAZ1A ACF1 WCRF180 HSPC317	Homo sapiens (Human)	1556	FUNCTION: Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}.	MISCELLANEOUS: Stimulated by double-stranded DNA and nucleosomal DNA.	chromatin remodeling [GO:0006338]; DNA-templated DNA replication [GO:0006261]; nucleosome assembly [GO:0006334]; positive regulation of DNA replication [GO:0045740]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of heterochromatin formation [GO:0031445]; regulation of transcription by RNA polymerase II [GO:0006357]	ACF complex [GO:0016590]; CHRAC [GO:0008623]; nuclear chromosome [GO:0000228]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	ACF complex [GO:0016590]; CHRAC [GO:0008623]; nuclear chromosome [GO:0000228]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; chromatin remodeling [GO:0006338]; DNA-templated DNA replication [GO:0006261]; nucleosome assembly [GO:0006334]; positive regulation of DNA replication [GO:0045740]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of heterochromatin formation [GO:0031445]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:25593309}. Note=Localizes to pericentric heterochromatin (By similarity). May target the CHRAC complex to heterochromatin (PubMed:10880450). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000250|UniProtKB:O88379, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:25593309}.
Q9NRL3	reviewed	STRN4_HUMAN	Striatin-4 (Zinedin)	STRN4 ZIN	Homo sapiens (Human)	753	FUNCTION: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.	MISCELLANEOUS: The name 'Zinedin' probably originates from the name of the famous soccer player from Marseille (Zinedine Zidane).		cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]; membrane [GO:0016020]	armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]; membrane [GO:0016020]; armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.
Q9NRM0	reviewed	GTR9_HUMAN	Solute carrier family 2, facilitated glucose transporter member 9 (Glucose transporter type 9) (GLUT-9) (Urate transporter)	SLC2A9 GLUT9	Homo sapiens (Human)	540	FUNCTION: High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:18327257, PubMed:28083649, PubMed:22647630, PubMed:18701466, PubMed:36749388). May have a residual high-affinity, low-capacity glucose and fructose transporter activity (PubMed:18842065, PubMed:18327257, PubMed:18701466). Transports urate at rates 45- to 60-fold faster than glucose (PubMed:18842065). Does not transport galactose (PubMed:28083649). May mediate small uptake of adenine but not of other nucleobases (PubMed:22647630). {ECO:0000269|PubMed:18327257, ECO:0000269|PubMed:18701466, ECO:0000269|PubMed:18842065, ECO:0000269|PubMed:22647630, ECO:0000269|PubMed:28083649}.		fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; monosaccharide transmembrane transport [GO:0015749]; urate metabolic process [GO:0046415]; urate transport [GO:0015747]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	carbohydrate:proton symporter activity [GO:0005351]; fructose transmembrane transporter activity [GO:0005353]; glucose transmembrane transporter activity [GO:0005355]; hexose transmembrane transporter activity [GO:0015149]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; carbohydrate:proton symporter activity [GO:0005351]; fructose transmembrane transporter activity [GO:0005353]; glucose transmembrane transporter activity [GO:0005355]; hexose transmembrane transporter activity [GO:0015149]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143]; fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; monosaccharide transmembrane transport [GO:0015749]; urate metabolic process [GO:0046415]; urate transport [GO:0015747]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:18701466}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:14739288, ECO:0000269|PubMed:24409316}; Multi-pass membrane protein {ECO:0000269|PubMed:14739288}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:18701466}. Apical cell membrane {ECO:0000269|PubMed:24409316}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:14739288, ECO:0000269|PubMed:24409316}; Multi-pass membrane protein {ECO:0000269|PubMed:14739288}.
Q9NRM1	reviewed	ENAM_HUMAN	Enamelin	ENAM	Homo sapiens (Human)	1142	FUNCTION: Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. {ECO:0000250|UniProtKB:O97939}.		ameloblast differentiation [GO:0036305]; amelogenesis [GO:0097186]; biomineral tissue development [GO:0031214]; positive regulation of enamel mineralization [GO:0070175]	endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	structural constituent of tooth enamel [GO:0030345]	endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; structural constituent of tooth enamel [GO:0030345]; ameloblast differentiation [GO:0036305]; amelogenesis [GO:0097186]; biomineral tissue development [GO:0031214]; positive regulation of enamel mineralization [GO:0070175]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:O97939}.
Q9NRM6	reviewed	I17RB_HUMAN	Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (Cytokine receptor-like 4) (IL-17 receptor homolog 1) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor)	IL17RB CRL4 EVI27 IL17BR UNQ2501/PRO19612	Homo sapiens (Human)	502	FUNCTION: Receptor for the pro-inflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. {ECO:0000269|PubMed:11058597}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	defense response [GO:0006952]; regulation of cell growth [GO:0001558]	extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cytokine receptor activity [GO:0004896]; interleukin-17 receptor activity [GO:0030368]	extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cytokine receptor activity [GO:0004896]; interleukin-17 receptor activity [GO:0030368]; defense response [GO:0006952]; regulation of cell growth [GO:0001558]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Q9NRM7	reviewed	LATS2_HUMAN	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)	LATS2 KPM	Homo sapiens (Human)	1088	FUNCTION: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048}.		canonical Wnt signaling pathway [GO:0060070]; cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; hippo signaling [GO:0035329]; hormone-mediated signaling pathway [GO:0009755]; inner cell mass cell fate commitment [GO:0001827]; inner cell mass cellular morphogenesis [GO:0001828]; intracellular signal transduction [GO:0035556]; keratinocyte differentiation [GO:0030216]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of apoptotic process [GO:0043065]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of organ growth [GO:0046620]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; canonical Wnt signaling pathway [GO:0060070]; cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; hippo signaling [GO:0035329]; hormone-mediated signaling pathway [GO:0009755]; inner cell mass cell fate commitment [GO:0001827]; inner cell mass cellular morphogenesis [GO:0001828]; intracellular signal transduction [GO:0035556]; keratinocyte differentiation [GO:0030216]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of apoptotic process [GO:0043065]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of organ growth [GO:0046620]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.
Q9NRN7	reviewed	ADPPT_HUMAN	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.7) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) (AASD-PPT) (LYS5 ortholog)	AASDHPPT CGI-80 HAH-P HSPC223 x0005	Homo sapiens (Human)	309	FUNCTION: Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN. {ECO:0000269|PubMed:11286508, ECO:0000269|PubMed:12815048, ECO:0000269|PubMed:18022563, ECO:0000269|PubMed:19933275, ECO:0000269|PubMed:21238436}.		10-formyltetrahydrofolate catabolic process [GO:0009258]; lysine biosynthetic process via aminoadipic acid [GO:0019878]; pantothenate metabolic process [GO:0015939]; protein maturation [GO:0051604]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287]; 10-formyltetrahydrofolate catabolic process [GO:0009258]; lysine biosynthetic process via aminoadipic acid [GO:0019878]; pantothenate metabolic process [GO:0015939]; protein maturation [GO:0051604]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12815048}.
Q9NRN9	reviewed	METL5_HUMAN	rRNA N6-adenosine-methyltransferase METTL5 (EC 2.1.1.-) (Methyltransferase-like protein 5)	METTL5 DC3 HSPC133	Homo sapiens (Human)	209	FUNCTION: Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:31328227, PubMed:32217665, PubMed:33357433, PubMed:33428944, PubMed:35033535). N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (PubMed:33357433). {ECO:0000269|PubMed:31328227, ECO:0000269|PubMed:32217665, ECO:0000269|PubMed:33357433, ECO:0000269|PubMed:33428944, ECO:0000269|PubMed:35033535}.		positive regulation of translation [GO:0045727]; rRNA methylation [GO:0031167]; stem cell differentiation [GO:0048863]	cell projection [GO:0042995]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleus [GO:0005634]; postsynapse [GO:0098794]; presynapse [GO:0098793]	nucleic acid binding [GO:0003676]; rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]; S-adenosyl-L-methionine binding [GO:1904047]	cell projection [GO:0042995]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleus [GO:0005634]; postsynapse [GO:0098794]; presynapse [GO:0098793]; nucleic acid binding [GO:0003676]; rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]; S-adenosyl-L-methionine binding [GO:1904047]; positive regulation of translation [GO:0045727]; rRNA methylation [GO:0031167]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31564433}. Presynapse {ECO:0000269|PubMed:31564433}. Postsynapse {ECO:0000269|PubMed:31564433}.
Q9NRP0	reviewed	OSTC_HUMAN	Oligosaccharyltransferase complex subunit OSTC (Hydrophobic protein HSF-28)	OSTC DC2 HDCMD45P HSPC307	Homo sapiens (Human)	149	FUNCTION: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. {ECO:0000269|PubMed:21768116, ECO:0000269|PubMed:31831667}.		protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	endoplasmic reticulum membrane [GO:0005789]; oligosaccharyltransferase complex [GO:0008250]		endoplasmic reticulum membrane [GO:0005789]; oligosaccharyltransferase complex [GO:0008250]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:21768116}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NRP7	reviewed	STK36_HUMAN	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog)	STK36 KIAA1278	Homo sapiens (Human)	1315	FUNCTION: Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:28543983}.		axoneme assembly [GO:0035082]; brain development [GO:0007420]; cilium assembly [GO:0060271]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; regulation of DNA-binding transcription factor activity [GO:0051090]; smoothened signaling pathway [GO:0007224]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transcription corepressor binding [GO:0001222]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transcription corepressor binding [GO:0001222]; axoneme assembly [GO:0035082]; brain development [GO:0007420]; cilium assembly [GO:0060271]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; regulation of DNA-binding transcription factor activity [GO:0051090]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10806483}. Nucleus {ECO:0000269|PubMed:10806483}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:28543983}. Note=Low levels also present in the nucleus. {ECO:0000269|PubMed:10806483}.
Q9NRQ2	reviewed	PLS4_HUMAN	Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4) (Cell growth-inhibiting gene 43 protein) (TRA1)	PLSCR4 GIG43	Homo sapiens (Human)	329	FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.		cellular response to lipopolysaccharide [GO:0071222]; plasma membrane phospholipid scrambling [GO:0017121]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; CD4 receptor binding [GO:0042609]; enzyme binding [GO:0019899]; phospholipid scramblase activity [GO:0017128]; SH3 domain binding [GO:0017124]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; CD4 receptor binding [GO:0042609]; enzyme binding [GO:0019899]; phospholipid scramblase activity [GO:0017128]; SH3 domain binding [GO:0017124]; cellular response to lipopolysaccharide [GO:0071222]; plasma membrane phospholipid scrambling [GO:0017121]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9NRQ5	reviewed	SMCO4_HUMAN	Single-pass membrane and coiled-coil domain-containing protein 4 (Protein FN5)	SMCO4 C11orf75 FN5	Homo sapiens (Human)	59				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NRR2	reviewed	TRYG1_HUMAN	Tryptase gamma (EC 3.4.21.-) (Serine protease 31) (Transmembrane tryptase) [Cleaved into: Tryptase gamma light chain; Tryptase gamma heavy chain]	TPSG1 PRSS31 TMT	Homo sapiens (Human)	321			proteolysis [GO:0006508]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NRR3	reviewed	C42S2_HUMAN	CDC42 small effector protein 2 (Small effector of CDC42 protein 2)	CDC42SE2 SPEC2	Homo sapiens (Human)	84	FUNCTION: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:15840583}.	MISCELLANEOUS: CDC42SE2 is mapped in the genomic region associated with schizophrenia.	phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023]; regulation of signal transduction [GO:0009966]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]	signaling adaptor activity [GO:0035591]; small GTPase binding [GO:0031267]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; signaling adaptor activity [GO:0035591]; small GTPase binding [GO:0031267]; phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.
Q9NRR4	reviewed	RNC_HUMAN	Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241)	DROSHA RN3 RNASE3L RNASEN	Homo sapiens (Human)	1374	FUNCTION: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}.		defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; miRNA metabolic process [GO:0010586]; positive regulation of gene expression [GO:0010628]; pre-miRNA processing [GO:0031054]; primary miRNA processing [GO:0031053]; regulation of inflammatory response [GO:0050727]; regulation of miRNA metabolic process [GO:2000628]; regulation of regulatory T cell differentiation [GO:0045589]; rRNA processing [GO:0006364]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; microprocessor complex [GO:0070877]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	DEAD/H-box RNA helicase binding [GO:0017151]; lipopolysaccharide binding [GO:0001530]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; R-SMAD binding [GO:0070412]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; microprocessor complex [GO:0070877]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; DEAD/H-box RNA helicase binding [GO:0017151]; lipopolysaccharide binding [GO:0001530]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; R-SMAD binding [GO:0070412]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; miRNA metabolic process [GO:0010586]; positive regulation of gene expression [GO:0010628]; pre-miRNA processing [GO:0031054]; primary miRNA processing [GO:0031053]; regulation of inflammatory response [GO:0050727]; regulation of miRNA metabolic process [GO:2000628]; regulation of regulatory T cell differentiation [GO:0045589]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:22118463}. Nucleus, nucleolus {ECO:0000269|PubMed:10948199}. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:22118463}.
Q9NRR5	reviewed	UBQL4_HUMAN	Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75)	UBQLN4 C1orf6 CIP75 UBIN	Homo sapiens (Human)	601	FUNCTION: Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}.	MISCELLANEOUS: May be a potential prognostic marker in cancer patients. {ECO:0000269|PubMed:34245648}.	autophagy [GO:0006914]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of autophagosome maturation [GO:1901097]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; ubiquitin-dependent protein catabolic process [GO:0006511]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734]	identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; polyubiquitin modification-dependent protein binding [GO:0031593]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; polyubiquitin modification-dependent protein binding [GO:0031593]; autophagy [GO:0006914]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of autophagosome maturation [GO:1901097]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11001934, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:34245648}. Cytoplasm {ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:34245648}. Chromosome {ECO:0000269|PubMed:30612738}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99NB8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q99NB8}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:23459205}. Note=Colocalizes with the proteasome, both in nucleus and cytoplasm (PubMed:15280365). Exported from the nucleus following interaction with DESI1/POST (PubMed:29666234). In response to DNA damage and phosphorylation at Ser-318 by ATM, localizes to the nucleus and is recruited to sites of DNA damage (PubMed:30612738). {ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}.
Q9NRR6	reviewed	INP5E_HUMAN	Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86)	INPP5E	Homo sapiens (Human)	644	FUNCTION: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10764818) (By similarity). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). {ECO:0000250|UniProtKB:Q9JII1, ECO:0000269|PubMed:10764818}.		negative regulation of protein localization to cilium [GO:1903565]; negative regulation of translation [GO:0017148]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]	axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]	axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; negative regulation of protein localization to cilium [GO:1903565]; negative regulation of translation [GO:0017148]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19668215, ECO:0000269|PubMed:19668216, ECO:0000269|PubMed:24166846}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9JII1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JII1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JII1}. Cell membrane {ECO:0000250|UniProtKB:Q9WVR1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVR1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVR1}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9WVR1}. Cytoplasm {ECO:0000250|UniProtKB:Q9WVR1}. Nucleus {ECO:0000250|UniProtKB:Q9JII1}. Note=Peripheral membrane protein associated with Golgi stacks. {ECO:0000250|UniProtKB:Q9JII1}.
Q9NRR8	reviewed	C42S1_HUMAN	CDC42 small effector protein 1 (CDC42-binding protein SCIP1) (Small effector of CDC42 protein 1)	CDC42SE1 SPEC1	Homo sapiens (Human)	79	FUNCTION: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:15840583, ECO:0000269|PubMed:17045588}.		phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]	GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267]; phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Note=Recruited to the activated TCR prior actin polymerization.
Q9NRS4	reviewed	TMPS4_HUMAN	Transmembrane protease serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (CAPH2) (Membrane-type serine protease 2) (MT-SP2) [Cleaved into: Transmembrane protease serine 4 catalytic chain]	TMPRSS4 TMPRSS3 UNQ776/PRO1570	Homo sapiens (Human)	437	FUNCTION: Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity). {ECO:0000250|UniProtKB:Q8VCA5, ECO:0000269|PubMed:24434139}.; FUNCTION: (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. {ECO:0000269|PubMed:32404436}.		negative regulation of growth rate [GO:0045967]; positive regulation of viral entry into host cell [GO:0046598]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of gene expression [GO:0010468]; response to wounding [GO:0009611]	extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; negative regulation of growth rate [GO:0045967]; positive regulation of viral entry into host cell [GO:0046598]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of gene expression [GO:0010468]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:24434139}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Transmembrane protease serine 4 catalytic chain]: Secreted {ECO:0000269|PubMed:24434139}. Note=Activated by cleavage and secreted. {ECO:0000269|PubMed:24434139}.
Q9NRS6	reviewed	SNX15_HUMAN	Sorting nexin-15	SNX15	Homo sapiens (Human)	342	FUNCTION: May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. {ECO:0000269|PubMed:11085978}.		intracellular protein transport [GO:0006886]	cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	phosphatidylinositol binding [GO:0035091]	cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; phosphatidylinositol binding [GO:0035091]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11085978}. Membrane {ECO:0000269|PubMed:11085978}; Peripheral membrane protein {ECO:0000269|PubMed:11085978}; Cytoplasmic side {ECO:0000269|PubMed:11085978}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:11085978}; Peripheral membrane protein {ECO:0000269|PubMed:11085978}; Cytoplasmic side {ECO:0000269|PubMed:11085978}.
Q9NRW1	reviewed	RAB6B_HUMAN	Ras-related protein Rab-6B (EC 3.6.5.2)	RAB6B	Homo sapiens (Human)	208	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (Probable). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866). {ECO:0000269|PubMed:17707369, ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:26209634, ECO:0000305}.		Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; neuron projection development [GO:0031175]; protein localization to Golgi membrane [GO:1903292]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; presynapse [GO:0098793]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; presynapse [GO:0098793]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; neuron projection development [GO:0031175]; protein localization to Golgi membrane [GO:1903292]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17707369, ECO:0000269|PubMed:18044744, ECO:0000269|PubMed:25492866}; Lipid-anchor {ECO:0000305}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:17707369}. Cytoplasmic vesicle {ECO:0000269|PubMed:17707369}. Note=Colocalizes with BICD1 at vesicular structures that align along microtubules. {ECO:0000269|PubMed:17707369}.
Q9NRW3	reviewed	ABC3C_HUMAN	DNA dC->dU-editing enzyme APOBEC-3C (A3C) (EC 3.5.4.38) (APOBEC1-like) (Phorbolin I)	APOBEC3C APOBEC1L PBI	Homo sapiens (Human)	190	FUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:15466872, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21632763}.	MISCELLANEOUS: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.	clearance of foreign intracellular DNA [GO:0044355]; cytidine deamination [GO:0009972]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of viral genome replication [GO:0045071]; retrotransposon silencing [GO:0010526]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]	cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; clearance of foreign intracellular DNA [GO:0044355]; cytidine deamination [GO:0009972]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of viral genome replication [GO:0045071]; retrotransposon silencing [GO:0010526]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22977230}. Cytoplasm {ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22977230}.
Q9NRW4	reviewed	DUS22_HUMAN	Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x)	DUSP22 JSP1 LMWDSP2 MKPX	Homo sapiens (Human)	184	FUNCTION: Activates the Jnk signaling pathway. {ECO:0000269|PubMed:11717427}.		cellular response to epidermal growth factor stimulus [GO:0071364]; dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of non-membrane spanning protein tyrosine kinase activity [GO:1903996]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell mediated immunity [GO:0002710]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of JNK cascade [GO:0046330]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; leading edge of lamellipodium [GO:0061851]; plasma membrane [GO:0005886]	myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; leading edge of lamellipodium [GO:0061851]; plasma membrane [GO:0005886]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cellular response to epidermal growth factor stimulus [GO:0071364]; dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of non-membrane spanning protein tyrosine kinase activity [GO:1903996]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell mediated immunity [GO:0002710]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of JNK cascade [GO:0046330]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20553486}.
Q9NRW7	reviewed	VPS45_HUMAN	Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45)	VPS45 VPS45A VPS45B	Homo sapiens (Human)	570	FUNCTION: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.		intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; synaptic vesicle [GO:0008021]		endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; synaptic vesicle [GO:0008021]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with Golgi/endosomal vesicles and the trans-Golgi network. {ECO:0000250}.
Q9NRX1	reviewed	PNO1_HUMAN	RNA-binding protein PNO1 (Partner of NOB1)	PNO1	Homo sapiens (Human)	252	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604). {ECO:0000269|PubMed:25851604, ECO:0000269|PubMed:34516797}.		ribosomal small subunit biogenesis [GO:0042274]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15497447, ECO:0000269|PubMed:34516797}.
Q9NRX4	reviewed	PHP14_HUMAN	14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) (Protein janus-A homolog)	PHPT1 PHP14 CGI-202 HSPC141	Homo sapiens (Human)	125	FUNCTION: Exhibits phosphohistidine phosphatase activity. {ECO:0000269|PubMed:19836471, ECO:0000269|PubMed:25574816}.		actin cytoskeleton organization [GO:0030036]; lamellipodium organization [GO:0097581]; negative regulation of ATP citrate synthase activity [GO:2000984]; negative regulation of lyase activity [GO:0051350]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-histidine dephosphorylation [GO:0035971]; positive regulation of cell motility [GO:2000147]; protein dephosphorylation [GO:0006470]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; leading edge of lamellipodium [GO:0061851]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; calcium channel inhibitor activity [GO:0019855]; protein histidine phosphatase activity [GO:0101006]; transmembrane transporter binding [GO:0044325]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; leading edge of lamellipodium [GO:0061851]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; calcium channel inhibitor activity [GO:0019855]; protein histidine phosphatase activity [GO:0101006]; transmembrane transporter binding [GO:0044325]; actin cytoskeleton organization [GO:0030036]; lamellipodium organization [GO:0097581]; negative regulation of ATP citrate synthase activity [GO:2000984]; negative regulation of lyase activity [GO:0051350]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-histidine dephosphorylation [GO:0035971]; positive regulation of cell motility [GO:2000147]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9NRX5	reviewed	SERC1_HUMAN	Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2)	SERINC1 KIAA1253 TDE1L TDE2 UNQ396/PRO732	Homo sapiens (Human)	453	FUNCTION: Enhances the incorporation of serine into phosphatidylserine and sphingolipids. {ECO:0000250|UniProtKB:Q7TNK0}.		membrane biogenesis [GO:0044091]; phosphatidylserine metabolic process [GO:0006658]; phospholipid biosynthetic process [GO:0008654]; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity [GO:1904219]; positive regulation of serine C-palmitoyltransferase activity [GO:1904222]; sphingolipid metabolic process [GO:0006665]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	protein-macromolecule adaptor activity [GO:0030674]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-macromolecule adaptor activity [GO:0030674]; membrane biogenesis [GO:0044091]; phosphatidylserine metabolic process [GO:0006658]; phospholipid biosynthetic process [GO:0008654]; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity [GO:1904219]; positive regulation of serine C-palmitoyltransferase activity [GO:1904222]; sphingolipid metabolic process [GO:0006665]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7TNK0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7TNK0}.
Q9NRX6	reviewed	KISHB_HUMAN	Protein kish-B (Transmembrane protein 167B)	TMEM167B C1orf119 AD-020	Homo sapiens (Human)	74	FUNCTION: Involved in the early part of the secretory pathway. {ECO:0000269|PubMed:19942856}.		constitutive secretory pathway [GO:0045054]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]		Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; constitutive secretory pathway [GO:0045054]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19942856}; Single-pass type I membrane protein {ECO:0000269|PubMed:19942856}.
Q9NRY2	reviewed	SOSSC_HUMAN	SOSS complex subunit C (INTS3- and NABP-interacting protein) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (SOSS-C) (Single-stranded DNA-binding protein-interacting protein 1) (SSB-interacting protein 1) (hSSBIP1)	INIP C9orf80 SSBIP1 HSPC043 HSPC291	Homo sapiens (Human)	104	FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic G2/M transition checkpoint [GO:0044818]; response to ionizing radiation [GO:0010212]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic G2/M transition checkpoint [GO:0044818]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage.
Q9NRY4	reviewed	RHG35_HUMAN	Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)	ARHGAP35 GRF1 GRLF1 KIAA1722 P190A p190ARHOGAP	Homo sapiens (Human)	1499	FUNCTION: Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}.		axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; camera-type eye development [GO:0043010]; cell migration [GO:0016477]; cellular response to extracellular stimulus [GO:0031668]; central nervous system neuron axonogenesis [GO:0021955]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; forebrain development [GO:0030900]; mammary gland development [GO:0030879]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of vascular permeability [GO:0043116]; neural tube closure [GO:0001843]; neuron projection guidance [GO:0097485]; positive regulation of cilium assembly [GO:0045724]; positive regulation of neuron projection development [GO:0010976]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of axonogenesis [GO:0050770]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; wound healing, spreading of cells [GO:0044319]	actin cytoskeleton [GO:0015629]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]; GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; phospholipid binding [GO:0005543]; protein-containing complex binding [GO:0044877]	actin cytoskeleton [GO:0015629]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; phospholipid binding [GO:0005543]; protein-containing complex binding [GO:0044877]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; camera-type eye development [GO:0043010]; cell migration [GO:0016477]; cellular response to extracellular stimulus [GO:0031668]; central nervous system neuron axonogenesis [GO:0021955]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; forebrain development [GO:0030900]; mammary gland development [GO:0030879]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of vascular permeability [GO:0043116]; neural tube closure [GO:0001843]; neuron projection guidance [GO:0097485]; positive regulation of cilium assembly [GO:0045724]; positive regulation of neuron projection development [GO:0010976]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of axonogenesis [GO:0050770]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q91YM2}. Cytoplasm {ECO:0000250|UniProtKB:Q91YM2}. Nucleus {ECO:0000305|PubMed:1894621}. Cell membrane {ECO:0000250|UniProtKB:Q91YM2}. Note=In response to integrins and SDC4 and upon phosphorylation by PKC, relocalizes from the cytoplasm to regions of plasma membrane ruffling where it colocalizes with polymerized actin. {ECO:0000250|UniProtKB:Q91YM2}.
Q9NRY6	reviewed	PLS3_HUMAN	Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3)	PLSCR3	Homo sapiens (Human)	295	FUNCTION: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:29337693, PubMed:31769662). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:12649167). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (PubMed:14573790, PubMed:17226776, PubMed:18358005). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (PubMed:18491232). Regulates cardiolipin de novo biosynthesis and its resynthesis (PubMed:16939411). {ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:14573790, ECO:0000269|PubMed:16939411, ECO:0000269|PubMed:17226776, ECO:0000269|PubMed:18358005, ECO:0000269|PubMed:18491232, ECO:0000269|PubMed:29337693, ECO:0000269|PubMed:31769662}.		apoptotic process [GO:0006915]; cardiolipin biosynthetic process [GO:0032049]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; glucose homeostasis [GO:0042593]; plasma membrane phospholipid scrambling [GO:0017121]; regulation of apoptotic process [GO:0042981]; regulation of release of cytochrome c from mitochondria [GO:0090199]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; lead ion binding [GO:0032791]; magnesium ion binding [GO:0000287]; mercury ion binding [GO:0045340]; phospholipid scramblase activity [GO:0017128]; protein self-association [GO:0043621]; SH3 domain binding [GO:0017124]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; lead ion binding [GO:0032791]; magnesium ion binding [GO:0000287]; mercury ion binding [GO:0045340]; phospholipid scramblase activity [GO:0017128]; protein self-association [GO:0043621]; SH3 domain binding [GO:0017124]; apoptotic process [GO:0006915]; cardiolipin biosynthetic process [GO:0032049]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; glucose homeostasis [GO:0042593]; plasma membrane phospholipid scrambling [GO:0017121]; regulation of apoptotic process [GO:0042981]; regulation of release of cytochrome c from mitochondria [GO:0090199]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:14573790, ECO:0000269|PubMed:17226776, ECO:0000269|PubMed:18491232}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6QBQ4}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q6QBQ4}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6QBQ4}. Nucleus {ECO:0000250|UniProtKB:Q9JIZ9}. Note=Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. {ECO:0000250|UniProtKB:Q9JIZ9}.
Q9NRY7	reviewed	PLS2_HUMAN	Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2)	PLSCR2	Homo sapiens (Human)	297	FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.; FUNCTION: Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain.		plasma membrane phospholipid scrambling [GO:0017121]	endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; phospholipid scramblase activity [GO:0017128]	endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; phospholipid scramblase activity [GO:0017128]; plasma membrane phospholipid scrambling [GO:0017121]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:24648509}.
Q9NRZ5	reviewed	PLCD_HUMAN	1-acyl-sn-glycerol-3-phosphate acyltransferase delta (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 4) (1-AGP acyltransferase 4) (1-AGPAT 4) (Lysophosphatidic acid acyltransferase delta) (LPAAT-delta)	AGPAT4 UNQ499/PRO1016	Homo sapiens (Human)	378	FUNCTION: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity). {ECO:0000250|UniProtKB:Q8K4X7}.		CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8K4X7}; Multi-pass membrane protein {ECO:0000255}.
Q9NRZ7	reviewed	PLCC_HUMAN	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 3) (1-AGP acyltransferase 3) (1-AGPAT 3) (Lysophosphatidic acid acyltransferase gamma) (LPAAT-gamma)	AGPAT3 LPAAT3 UNQ759/PRO1490	Homo sapiens (Human)	376	FUNCTION: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity). {ECO:0000250|UniProtKB:Q9D517, ECO:0000269|PubMed:21173190}.		CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20537980, ECO:0000269|PubMed:21173190}; Multi-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:21173190}.
Q9NRZ9	reviewed	HELLS_HUMAN	Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)	HELLS PASG SMARCA6 Nbla10143	Homo sapiens (Human)	838	FUNCTION: Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA methylation [GO:0006306]; DNA methylation-dependent heterochromatin formation [GO:0006346]; kidney development [GO:0001822]; lymphocyte proliferation [GO:0046651]; negative regulation of gene expression via CpG island methylation [GO:0044027]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; pericentric heterochromatin formation [GO:0031508]; urogenital system development [GO:0001655]	chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]	chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA methylation [GO:0006306]; DNA methylation-dependent heterochromatin formation [GO:0006346]; kidney development [GO:0001822]; lymphocyte proliferation [GO:0046651]; negative regulation of gene expression via CpG island methylation [GO:0044027]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; pericentric heterochromatin formation [GO:0031508]; urogenital system development [GO:0001655]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Closely associated with pericentric heterochromatin. {ECO:0000250}.
Q9NS00	reviewed	C1GLT_HUMAN	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (B3Gal-T8) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Beta-1,3-galactosyltransferase) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1)	C1GALT1	Homo sapiens (Human)	363	FUNCTION: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.	MISCELLANEOUS: Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN.	angiogenesis [GO:0001525]; intestinal epithelial cell development [GO:0060576]; kidney development [GO:0001822]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263]; metal ion binding [GO:0046872]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263]; metal ion binding [GO:0046872]; angiogenesis [GO:0001525]; intestinal epithelial cell development [GO:0060576]; kidney development [GO:0001822]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9NS15	reviewed	LTBP3_HUMAN	Latent-transforming growth factor beta-binding protein 3 (LTBP-3)	LTBP3	Homo sapiens (Human)	1303	FUNCTION: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. {ECO:0000303|PubMed:10743502, ECO:0000303|PubMed:11104663}.		bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; chondrocyte differentiation [GO:0002062]; lung saccule development [GO:0060430]; negative regulation of bone mineralization [GO:0030502]; negative regulation of chondrocyte differentiation [GO:0032331]; positive regulation of bone resorption [GO:0045780]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; transforming growth factor beta activation [GO:0036363]; transforming growth factor beta receptor signaling pathway [GO:0007179]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; transforming growth factor beta binding [GO:0050431]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; transforming growth factor beta binding [GO:0050431]; bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; chondrocyte differentiation [GO:0002062]; lung saccule development [GO:0060430]; negative regulation of bone mineralization [GO:0030502]; negative regulation of chondrocyte differentiation [GO:0032331]; positive regulation of bone resorption [GO:0045780]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; transforming growth factor beta activation [GO:0036363]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12154076}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:16157329}. Note=Secretion occurs after coexpression with TGFB1 and requires complexing with 'Cys-33' of the TGFB1 propeptide. {ECO:0000269|PubMed:12154076}.
Q9NS18	reviewed	GLRX2_HUMAN	Glutaredoxin-2, mitochondrial	GLRX2 GRX2 CGI-133	Homo sapiens (Human)	164	FUNCTION: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. {ECO:0000269|PubMed:11297543, ECO:0000269|PubMed:14676218, ECO:0000269|PubMed:15328416, ECO:0000269|PubMed:15649413}.	MISCELLANEOUS: The absence of GLRX2 dramatically sensitizes cells to cell death induced by doxorubicin/adriamycin and phenylarsine oxide.	apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; cellular response to superoxide [GO:0071451]; DNA protection [GO:0042262]; glutathione metabolic process [GO:0006749]; regulation of DNA-templated transcription [GO:0006355]; regulation of signal transduction [GO:0009966]; response to hydrogen peroxide [GO:0042542]; response to organic substance [GO:0010033]; response to redox state [GO:0051775]; response to temperature stimulus [GO:0009266]	dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	2 iron, 2 sulfur cluster binding [GO:0051537]; arsenate reductase (glutaredoxin) activity [GO:0008794]; electron transfer activity [GO:0009055]; glutathione disulfide oxidoreductase activity [GO:0015038]; metal ion binding [GO:0046872]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]	dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 2 iron, 2 sulfur cluster binding [GO:0051537]; arsenate reductase (glutaredoxin) activity [GO:0008794]; electron transfer activity [GO:0009055]; glutathione disulfide oxidoreductase activity [GO:0015038]; metal ion binding [GO:0046872]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; cellular response to superoxide [GO:0071451]; DNA protection [GO:0042262]; glutathione metabolic process [GO:0006749]; regulation of DNA-templated transcription [GO:0006355]; regulation of signal transduction [GO:0009966]; response to hydrogen peroxide [GO:0042542]; response to organic substance [GO:0010033]; response to redox state [GO:0051775]; response to temperature stimulus [GO:0009266]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
Q9NS23	reviewed	RASF1_HUMAN	Ras association domain-containing protein 1	RASSF1 RDA32	Homo sapiens (Human)	344	FUNCTION: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291, ECO:0000269|PubMed:12024041, ECO:0000269|PubMed:14743218, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:15949439, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:21199877}.	MISCELLANEOUS: [Isoform D]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform A]: Produced by alternative splicing of isoform D. {ECO:0000305}.; MISCELLANEOUS: [Isoform B]: Produced by alternative splicing of isoform D. {ECO:0000305}.; MISCELLANEOUS: [Isoform C]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform E]: Produced by alternative splicing of isoform D. {ECO:0000305}.; MISCELLANEOUS: [Isoform F]: Produced by alternative splicing of isoform D. {ECO:0000305}.; MISCELLANEOUS: [Isoform G]: Produced by alternative splicing of isoform D. {ECO:0000305}.; MISCELLANEOUS: [Isoform H]: Produced by alternative splicing of isoform C. {ECO:0000305}.	cell cycle [GO:0007049]; DNA damage response [GO:0006974]; positive regulation of protein ubiquitination [GO:0031398]; protein stabilization [GO:0050821]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G1/S phase transition [GO:1902806]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; spindle pole [GO:0000922]	identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; spindle pole [GO:0000922]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; DNA damage response [GO:0006974]; positive regulation of protein ubiquitination [GO:0031398]; protein stabilization [GO:0050821]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G1/S phase transition [GO:1902806]	SUBCELLULAR LOCATION: [Isoform A]: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus.; SUBCELLULAR LOCATION: [Isoform C]: Nucleus. Note=Predominantly nuclear.
Q9NS37	reviewed	ZHANG_HUMAN	CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei)	CREBZF ZF	Homo sapiens (Human)	354	FUNCTION: Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}.	MISCELLANEOUS: Named 'Zhangfei' after a legendary Chinese warrior who was contemporary with Luman in around 220 AD.	ATF6-mediated unfolded protein response [GO:0036500]; integrated stress response signaling [GO:0140467]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]	chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]	chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; ATF6-mediated unfolded protein response [GO:0036500]; integrated stress response signaling [GO:0140467]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15705566}. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.
Q9NS39	reviewed	RED2_HUMAN	Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2) (dsRNA adenosine deaminase B2)	ADARB2 ADAR3 RED2	Homo sapiens (Human)	739	FUNCTION: Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA.		adenosine to inosine editing [GO:0006382]; mRNA processing [GO:0006397]; RNA processing [GO:0006396]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	adenosine deaminase activity [GO:0004000]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; tRNA-specific adenosine deaminase activity [GO:0008251]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; adenosine deaminase activity [GO:0004000]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; tRNA-specific adenosine deaminase activity [GO:0008251]; adenosine to inosine editing [GO:0006382]; mRNA processing [GO:0006397]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus.
Q9NS40	reviewed	KCNH7_HUMAN	Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (hERG-3) (Voltage-gated potassium channel subunit Kv11.3)	KCNH7 ERG3	Homo sapiens (Human)	1196	FUNCTION: Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.		circadian rhythm [GO:0007623]; membrane repolarization during action potential [GO:0086011]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]	plasma membrane [GO:0005886]	inward rectifier potassium channel activity [GO:0005242]; protein-containing complex binding [GO:0044877]	plasma membrane [GO:0005886]; inward rectifier potassium channel activity [GO:0005242]; protein-containing complex binding [GO:0044877]; circadian rhythm [GO:0007623]; membrane repolarization during action potential [GO:0086011]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NS56	reviewed	TOPRS_HUMAN	E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)	TOPORS LUN TP53BPL	Homo sapiens (Human)	1045	FUNCTION: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}.		DNA damage response [GO:0006974]; DNA-templated transcription [GO:0006351]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of apoptotic process [GO:0043066]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein localization to nucleus [GO:0034504]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein sumoylation [GO:0016925]; regulation of cell population proliferation [GO:0042127]; retina layer formation [GO:0010842]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; ubiquitin-dependent protein catabolic process [GO:0006511]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; gamma-tubulin complex [GO:0000930]; midbody [GO:0030496]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; PML body [GO:0016605]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151]	antigen binding [GO:0003823]; DNA binding [GO:0003677]; DNA topoisomerase binding [GO:0044547]; metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; gamma-tubulin complex [GO:0000930]; midbody [GO:0030496]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; PML body [GO:0016605]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151]; antigen binding [GO:0003823]; DNA binding [GO:0003677]; DNA topoisomerase binding [GO:0044547]; metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; DNA damage response [GO:0006974]; DNA-templated transcription [GO:0006351]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of apoptotic process [GO:0043066]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein localization to nucleus [GO:0034504]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein sumoylation [GO:0016925]; regulation of cell population proliferation [GO:0042127]; retina layer formation [GO:0010842]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
Q9NS61	reviewed	KCIP2_HUMAN	Kv channel-interacting protein 2 (KChIP2) (A-type potassium channel modulatory protein 2) (Cardiac voltage-gated potassium channel modulatory subunit) (Potassium channel-interacting protein 2)	KCNIP2 KCHIP2	Homo sapiens (Human)	270	FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity). {ECO:0000250|UniProtKB:Q9JJ69, ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11287421, ECO:0000269|PubMed:11684073, ECO:0000269|PubMed:12297301, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:14623880}.		action potential [GO:0001508]; chemical synaptic transmission [GO:0007268]; clustering of voltage-gated potassium channels [GO:0045163]; detection of calcium ion [GO:0005513]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; muscle contraction [GO:0006936]; positive regulation of potassium ion export across plasma membrane [GO:1903766]; positive regulation of voltage-gated potassium channel activity [GO:1903818]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transport [GO:0006813]; regulation of heart contraction [GO:0008016]; regulation of potassium ion transmembrane transport [GO:1901379]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; Kv4.2-KChIP2 channel complex [GO:0071193]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]	calcium ion binding [GO:0005509]; ER retention sequence binding [GO:0046923]; identical protein binding [GO:0042802]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; protein-containing complex binding [GO:0044877]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity [GO:0005244]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; Kv4.2-KChIP2 channel complex [GO:0071193]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]; calcium ion binding [GO:0005509]; ER retention sequence binding [GO:0046923]; identical protein binding [GO:0042802]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; protein-containing complex binding [GO:0044877]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity [GO:0005244]; action potential [GO:0001508]; chemical synaptic transmission [GO:0007268]; clustering of voltage-gated potassium channels [GO:0045163]; detection of calcium ion [GO:0005513]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; muscle contraction [GO:0006936]; positive regulation of potassium ion export across plasma membrane [GO:1903766]; positive regulation of voltage-gated potassium channel activity [GO:1903818]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transport [GO:0006813]; regulation of heart contraction [GO:0008016]; regulation of potassium ion transmembrane transport [GO:1901379]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:Q9JM59}; Lipid-anchor {ECO:0000250|UniProtKB:Q9JM59}. Note=Detected on lipid rafts (By similarity). {ECO:0000250|UniProtKB:Q9JM59}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000250|UniProtKB:Q9JM59}; Lipid-anchor {ECO:0000250|UniProtKB:Q9JM59}.; SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane {ECO:0000250|UniProtKB:Q9JM59}; Lipid-anchor {ECO:0000250|UniProtKB:Q9JM59}.
Q9NS62	reviewed	THSD1_HUMAN	Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module)	THSD1 TMTSP UNQ3010/PRO9769	Homo sapiens (Human)	852	FUNCTION: Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix. {ECO:0000269|PubMed:27895300, ECO:0000269|PubMed:29069646}.		focal adhesion assembly [GO:0048041]	cell periphery [GO:0071944]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]	extracellular matrix binding [GO:0050840]	cell periphery [GO:0071944]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; extracellular matrix binding [GO:0050840]; focal adhesion assembly [GO:0048041]	SUBCELLULAR LOCATION: [Isoform 1]: Endosome membrane {ECO:0000269|PubMed:29069646}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, focal adhesion {ECO:0000269|PubMed:29069646}. Note=Localizes to nascent focal adhesions. {ECO:0000269|PubMed:29069646}.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Q9NS64	reviewed	RPRM_HUMAN	Protein reprimo	RPRM	Homo sapiens (Human)	109	FUNCTION: May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity). {ECO:0000250}.	MISCELLANEOUS: 'Reprimo' signifies stop/repress.	regulation of cell cycle [GO:0051726]; regulation of mitotic cell cycle [GO:0007346]	cytoplasm [GO:0005737]; membrane [GO:0016020]		cytoplasm [GO:0005737]; membrane [GO:0016020]; regulation of cell cycle [GO:0051726]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NS68	reviewed	TNR19_HUMAN	Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer)	TNFRSF19 TAJ TROY UNQ1888/PRO4333	Homo sapiens (Human)	423	FUNCTION: Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.		apoptotic process [GO:0006915]; hair follicle development [GO:0001942]; JNK cascade [GO:0007254]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330]	membrane [GO:0016020]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]; tumor necrosis factor receptor activity [GO:0005031]	membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; tumor necrosis factor receptor activity [GO:0005031]; apoptotic process [GO:0006915]; hair follicle development [GO:0001942]; JNK cascade [GO:0007254]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9NS69	reviewed	TOM22_HUMAN	Mitochondrial import receptor subunit TOM22 homolog (hTom22) (1C9-2) (Translocase of outer membrane 22 kDa subunit homolog)	TOMM22 TOM22	Homo sapiens (Human)	142	FUNCTION: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (PubMed:10982837). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity). {ECO:0000250|UniProtKB:Q75Q41, ECO:0000269|PubMed:10982837}.		protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]	protein transmembrane transporter activity [GO:0008320]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; protein transmembrane transporter activity [GO:0008320]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:10982837}; Single-pass membrane protein {ECO:0000269|PubMed:10982837}.
Q9NS71	reviewed	GKN1_HUMAN	Gastrokine-1 (18 kDa antrum mucosa protein) (AMP-18) (Protein CA11)	GKN1 AMP18 CA11 UNQ489/PRO1005	Homo sapiens (Human)	185	FUNCTION: Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. {ECO:0000269|PubMed:12851218}.		digestion [GO:0007586]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; regulation of cell population proliferation [GO:0042127]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; secretory granule [GO:0030141]	growth factor activity [GO:0008083]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; secretory granule [GO:0030141]; growth factor activity [GO:0008083]; digestion [GO:0007586]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15221938}. Cytoplasmic granule {ECO:0000269|PubMed:15221938}. Golgi apparatus {ECO:0000305|PubMed:15221938}. Note=Shows abundant granular cytoplasmic staining, with perinuclear accentuation suggestive of the Golgi apparatus. {ECO:0000269|PubMed:15221938}.
Q9NS73	reviewed	MBIP1_HUMAN	MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein)	MBIP BM-015	Homo sapiens (Human)	344	FUNCTION: Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	ATAC complex [GO:0140672]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	identical protein binding [GO:0042802]; protein kinase inhibitor activity [GO:0004860]	ATAC complex [GO:0140672]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; protein kinase inhibitor activity [GO:0004860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shows a cytoplasmic localization when coexpressed with MAP3K12.
Q9NS75	reviewed	CLTR2_HUMAN	Cysteinyl leukotriene receptor 2 (CysLTR2) (G-protein coupled receptor GPCR21) (hGPCR21) (G-protein coupled receptor HG57) (HPN321)	CYSLTR2 CYSLT2 CYSLT2R PSEC0146	Homo sapiens (Human)	346	FUNCTION: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.		immune response [GO:0006955]; neuropeptide signaling pathway [GO:0007218]	plasma membrane [GO:0005886]	cysteinyl leukotriene receptor activity [GO:0001631]; G protein-coupled peptide receptor activity [GO:0008528]; leukotriene receptor activity [GO:0004974]	plasma membrane [GO:0005886]; cysteinyl leukotriene receptor activity [GO:0001631]; G protein-coupled peptide receptor activity [GO:0008528]; leukotriene receptor activity [GO:0004974]; immune response [GO:0006955]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9NS82	reviewed	AAA1_HUMAN	Asc-type amino acid transporter 1 (Asc-1) (Solute carrier family 7 member 10)	SLC7A10 ASC1	Homo sapiens (Human)	523	FUNCTION: Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion (By similarity) (PubMed:10863037). Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (By similarity). At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission (By similarity). May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (By similarity). {ECO:0000250|UniProtKB:P63115, ECO:0000250|UniProtKB:P63116, ECO:0000269|PubMed:10863037}.		amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; D-alanine transport [GO:0042941]; D-serine transport [GO:0042942]; glycine transport [GO:0015816]; negative regulation of brown fat cell differentiation [GO:1903444]; neutral amino acid transport [GO:0015804]; positive regulation of synaptic transmission, glycinergic [GO:0060094]	membrane [GO:0016020]; plasma membrane [GO:0005886]	L-amino acid transmembrane transporter activity [GO:0015179]; L-serine transmembrane transporter activity [GO:0015194]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	membrane [GO:0016020]; plasma membrane [GO:0005886]; L-amino acid transmembrane transporter activity [GO:0015179]; L-serine transmembrane transporter activity [GO:0015194]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; D-alanine transport [GO:0042941]; D-serine transport [GO:0042942]; glycine transport [GO:0015816]; negative regulation of brown fat cell differentiation [GO:1903444]; neutral amino acid transport [GO:0015804]; positive regulation of synaptic transmission, glycinergic [GO:0060094]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P63115}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with OLIG2 in astrocytic processes. Localizes to the plasma membrane in mature adipocytes and to intracellular structures in preadipocytes. {ECO:0000250|UniProtKB:P63115}.
Q9NS84	reviewed	CHST7_HUMAN	Carbohydrate sulfotransferase 7 (EC 2.8.2.-) (EC 2.8.2.17) (Chondroitin 6-sulfotransferase 2) (C6ST-2) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5) (GST-5) (N-acetylglucosamine 6-O-sulfotransferase 4) (GlcNAc6ST-4) (Gn6st-4)	CHST7	Homo sapiens (Human)	486	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc. {ECO:0000269|PubMed:10781596, ECO:0000269|PubMed:10913333, ECO:0000269|PubMed:10956661}.		chondroitin sulfate biosynthetic process [GO:0030206]; N-acetylglucosamine metabolic process [GO:0006044]; polysaccharide metabolic process [GO:0005976]; sulfur compound metabolic process [GO:0006790]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	chondroitin 6-sulfotransferase activity [GO:0008459]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; chondroitin 6-sulfotransferase activity [GO:0008459]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; chondroitin sulfate biosynthetic process [GO:0030206]; N-acetylglucosamine metabolic process [GO:0006044]; polysaccharide metabolic process [GO:0005976]; sulfur compound metabolic process [GO:0006790]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9NS86	reviewed	LANC2_HUMAN	LanC-like protein 2 (Testis-specific adriamycin sensitivity protein)	LANCL2 GPR69B TASP	Homo sapiens (Human)	450	FUNCTION: Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. {ECO:0000269|PubMed:19667068}.	MISCELLANEOUS: Its exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P-glycoprotein 1) and increases cellular sensitivity to an anticancer drug (adriamycin).	carbohydrate metabolic process [GO:0005975]; negative regulation of DNA-templated transcription [GO:0045892]; peptide modification [GO:0031179]; positive regulation of abscisic acid-activated signaling pathway [GO:0009789]	cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]	cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; carbohydrate metabolic process [GO:0005975]; negative regulation of DNA-templated transcription [GO:0045892]; peptide modification [GO:0031179]; positive regulation of abscisic acid-activated signaling pathway [GO:0009789]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12566319}. Cytoplasm {ECO:0000269|PubMed:12566319}. Cell membrane {ECO:0000269|PubMed:12566319, ECO:0000269|PubMed:16979580}. Note=Localizes to the juxta-nuclear vesicles (PubMed:16979580). Associates with the cortical actin cytoskeleton (PubMed:16979580). Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580). Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580). {ECO:0000269|PubMed:16979580}.
Q9NS87	reviewed	KIF15_HUMAN	Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62)	KIF15 KLP2 KNSL7	Homo sapiens (Human)	1388	FUNCTION: Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}.		microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]	centrosome [GO:0005813]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; plus-end kinesin complex [GO:0005873]; spindle [GO:0005819]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	centrosome [GO:0005813]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; plus-end kinesin complex [GO:0005873]; spindle [GO:0005819]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis. Localizes at the central spindle at anaphase (By similarity). Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells (By similarity). Colocalizes with actin in interphase (By similarity). Colocalizes in dendrites and in growth cone of axons with microtubules (By similarity). {ECO:0000250}.
Q9NS91	reviewed	RAD18_HUMAN	E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18)	RAD18 RNF73	Homo sapiens (Human)	495	FUNCTION: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; positive regulation of chromosome segregation [GO:0051984]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad6-Rad18 complex [GO:0097505]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]	damaged DNA binding [GO:0003684]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-containing complex binding [GO:0044877]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; Y-form DNA binding [GO:0000403]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad6-Rad18 complex [GO:0097505]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]; damaged DNA binding [GO:0003684]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-containing complex binding [GO:0044877]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; Y-form DNA binding [GO:0000403]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; positive regulation of chromosome segregation [GO:0051984]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15632077, ECO:0000269|PubMed:22036607, ECO:0000269|PubMed:25931565}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15632077}. Note=Associates with chromatin (PubMed:25931565). Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077). Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607). Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). {ECO:0000269|PubMed:15632077, ECO:0000269|PubMed:22036607, ECO:0000269|PubMed:25931565}.
Q9NSA0	reviewed	S22AB_HUMAN	Solute carrier family 22 member 11 (Organic anion transporter 4) (OAT4) (Organic anion:dicarboxylate exchanger OAT4)	SLC22A11 OAT4	Homo sapiens (Human)	550	FUNCTION: Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds (PubMed:10660625, PubMed:11907186, PubMed:15291761, PubMed:15037815, PubMed:15102942, PubMed:15576633, PubMed:17229912, PubMed:18501590, PubMed:26277985, PubMed:28027879). May be responsible for placental absorption of fetal-derived steroid sulfates such as estrone sulfate (E1S) and the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S), as well as clearing waste products and xenobiotics from the fetus (PubMed:12409283). Maybe also be involved in placental urate homeostasis (PubMed:17229912). Facilitates the renal reabsorption of organic anions such as urate and derived steroid sulfates (PubMed:15037815, PubMed:17229912). Organic anion glutarate acts as conteranion for E1S renal uptake (PubMed:15037815, PubMed:17229912). Possible transport mode may also include DHEA-S/E1S exchange (PubMed:28027879). Also interacts with inorganic anions such as chloride and hydroxyl ions, therefore possible transport modes may include E1S/Cl(-), E1S/OH(-), urate/Cl(-) and urate/OH(-) (PubMed:17229912). Also mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (PubMed:11907186). Also able to uptake anionic drugs, diuretics, bile salts and ochratoxin A (PubMed:10660625, PubMed:26277985). Mediates the unidirectional efflux of glutamate and aspartate (PubMed:28027879). Glutamate efflux down its transmembrane gradient may drive SLC22A11/OAT4-mediated placental uptake of E1S (PubMed:26277985). {ECO:0000269|PubMed:10660625, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:15037815, ECO:0000269|PubMed:15102942, ECO:0000269|PubMed:15291761, ECO:0000269|PubMed:15576633, ECO:0000269|PubMed:17229912, ECO:0000269|PubMed:18501590, ECO:0000269|PubMed:26277985, ECO:0000269|PubMed:28027879, ECO:0000303|PubMed:17229912}.		monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; prostaglandin transport [GO:0015732]; urate metabolic process [GO:0046415]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; solute:inorganic anion antiporter activity [GO:0005452]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; solute:inorganic anion antiporter activity [GO:0005452]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; prostaglandin transport [GO:0015732]; urate metabolic process [GO:0046415]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15291761, ECO:0000269|PubMed:15576633}; Multi-pass membrane protein {ECO:0000269|PubMed:15291761, ECO:0000269|PubMed:15576633}. Apical cell membrane {ECO:0000269|PubMed:15037815}; Multi-pass membrane protein {ECO:0000269|PubMed:15291761, ECO:0000269|PubMed:15576633}. Basal cell membrane {ECO:0000269|PubMed:12409283}; Multi-pass membrane protein {ECO:0000269|PubMed:15291761, ECO:0000269|PubMed:15576633}. Note=Expressed at the apical membrane of the proximal tubule epithelial cells (PubMed:15037815). Expressed at the basal membrane of the syncytiotrophoblast (PubMed:12409283). {ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:15037815}.
Q9NSA1	reviewed	FGF21_HUMAN	Fibroblast growth factor 21 (FGF-21)	FGF21 UNQ3115/PRO10196	Homo sapiens (Human)	209	FUNCTION: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity. {ECO:0000250|UniProtKB:Q9JJN1, ECO:0000269|PubMed:15902306, ECO:0000269|PubMed:17623664}.		animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to xenobiotic stimulus [GO:0071466]; endoplasmic reticulum unfolded protein response [GO:0030968]; endothelial cell apoptotic process [GO:0072577]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of endothelial cell apoptotic process [GO:2000352]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of triglyceride catabolic process [GO:0010898]; regulation of cell migration [GO:0030334]; regulation of low-density lipoprotein particle clearance [GO:0010988]; response to activity [GO:0014823]; response to methionine [GO:1904640]; response to nutrient levels [GO:0031667]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to xenobiotic stimulus [GO:0071466]; endoplasmic reticulum unfolded protein response [GO:0030968]; endothelial cell apoptotic process [GO:0072577]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of endothelial cell apoptotic process [GO:2000352]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of triglyceride catabolic process [GO:0010898]; regulation of cell migration [GO:0030334]; regulation of low-density lipoprotein particle clearance [GO:0010988]; response to activity [GO:0014823]; response to methionine [GO:1904640]; response to nutrient levels [GO:0031667]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9JJN1}.
Q9NSA2	reviewed	KCND1_HUMAN	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1)	KCND1	Homo sapiens (Human)	647	FUNCTION: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.		potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076]	A-type (transient outward) potassium channel activity [GO:0005250]; metal ion binding [GO:0046872]	dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076]; A-type (transient outward) potassium channel activity [GO:0005250]; metal ion binding [GO:0046872]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}.
Q9NSA3	reviewed	CNBP1_HUMAN	Beta-catenin-interacting protein 1 (Inhibitor of beta-catenin and Tcf-4)	CTNNBIP1 ICAT	Homo sapiens (Human)	81	FUNCTION: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. {ECO:0000269|PubMed:12408824}.		anterior/posterior pattern specification [GO:0009952]; branching involved in ureteric bud morphogenesis [GO:0001658]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of protein binding [GO:0032091]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of vascular permeability involved in acute inflammatory response [GO:0002528]; Wnt signaling pathway [GO:0016055]	beta-catenin destruction complex [GO:0030877]; beta-catenin-ICAT complex [GO:1990711]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]	beta-catenin destruction complex [GO:0030877]; beta-catenin-ICAT complex [GO:1990711]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; anterior/posterior pattern specification [GO:0009952]; branching involved in ureteric bud morphogenesis [GO:0001658]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of protein binding [GO:0032091]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of vascular permeability involved in acute inflammatory response [GO:0002528]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q9NSB2	reviewed	KRT84_HUMAN	Keratin, type II cuticular Hb4 (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24)	KRT84 KRTHB4	Homo sapiens (Human)	600		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	hair follicle development [GO:0001942]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; nail development [GO:0035878]; regulation of keratinocyte differentiation [GO:0045616]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]	structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280]; hair follicle development [GO:0001942]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; nail development [GO:0035878]; regulation of keratinocyte differentiation [GO:0045616]	
Q9NSB4	reviewed	KRT82_HUMAN	Keratin, type II cuticular Hb2 (Keratin-82) (K82) (Type II hair keratin Hb2) (Type-II keratin Kb22)	KRT82 KRTHB2	Homo sapiens (Human)	513		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	cytosol [GO:0005829]; keratin filament [GO:0045095]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; keratin filament [GO:0045095]; structural constituent of skin epidermis [GO:0030280]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]	
Q9NSB8	reviewed	HOME2_HUMAN	Homer protein homolog 2 (Homer-2) (Cupidin)	HOMER2	Homo sapiens (Human)	354	FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901, ECO:0000269|PubMed:25816005, ECO:0000269|PubMed:9808459}.		behavioral response to cocaine [GO:0048148]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of interleukin-2 production [GO:0032703]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of store-operated calcium entry [GO:2001256]; sensory perception of sound [GO:0007605]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; stereocilium tip [GO:0032426]	actin binding [GO:0003779]; G protein-coupled glutamate receptor binding [GO:0035256]; synaptic receptor adaptor activity [GO:0030160]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; stereocilium tip [GO:0032426]; actin binding [GO:0003779]; G protein-coupled glutamate receptor binding [GO:0035256]; synaptic receptor adaptor activity [GO:0030160]; behavioral response to cocaine [GO:0048148]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of interleukin-2 production [GO:0032703]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of store-operated calcium entry [GO:2001256]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25816005}. Cell membrane {ECO:0000250|UniProtKB:O88801}. Postsynaptic density. Synapse. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q9QWW1}. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
Q9NSC2	reviewed	SALL1_HUMAN	Sal-like protein 1 (Spalt-like transcription factor 1) (Zinc finger protein 794) (Zinc finger protein SALL1) (Zinc finger protein Spalt-1) (HSal1) (Sal-1)	SALL1 SAL1 ZNF794	Homo sapiens (Human)	1324	FUNCTION: Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development. {ECO:0000250|UniProtKB:Q9ER74}.		adrenal gland development [GO:0030325]; branching involved in ureteric bud morphogenesis [GO:0001658]; embryonic digestive tract development [GO:0048566]; embryonic digit morphogenesis [GO:0042733]; gonad development [GO:0008406]; heart development [GO:0007507]; inductive cell-cell signaling [GO:0031129]; kidney development [GO:0001822]; kidney epithelium development [GO:0072073]; limb development [GO:0060173]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; olfactory bulb interneuron differentiation [GO:0021889]; olfactory bulb mitral cell layer development [GO:0061034]; olfactory nerve development [GO:0021553]; pituitary gland development [GO:0021983]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of transcription by RNA polymerase II [GO:0006357]; ureteric bud development [GO:0001657]; ureteric bud invasion [GO:0072092]; ventricular septum development [GO:0003281]	chromocenter [GO:0010369]; cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromocenter [GO:0010369]; cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; adrenal gland development [GO:0030325]; branching involved in ureteric bud morphogenesis [GO:0001658]; embryonic digestive tract development [GO:0048566]; embryonic digit morphogenesis [GO:0042733]; gonad development [GO:0008406]; heart development [GO:0007507]; inductive cell-cell signaling [GO:0031129]; kidney development [GO:0001822]; kidney epithelium development [GO:0072073]; limb development [GO:0060173]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; olfactory bulb interneuron differentiation [GO:0021889]; olfactory bulb mitral cell layer development [GO:0061034]; olfactory nerve development [GO:0021553]; pituitary gland development [GO:0021983]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of transcription by RNA polymerase II [GO:0006357]; ureteric bud development [GO:0001657]; ureteric bud invasion [GO:0072092]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ER74}.
Q9NSC5	reviewed	HOME3_HUMAN	Homer protein homolog 3 (Homer-3)	HOMER3	Homo sapiens (Human)	361	FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}.		G protein-coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of interleukin-2 production [GO:0032703]; protein targeting [GO:0006605]; regulation of store-operated calcium entry [GO:2001256]	basal part of cell [GO:0045178]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	G protein-coupled glutamate receptor binding [GO:0035256]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	basal part of cell [GO:0045178]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; G protein-coupled glutamate receptor binding [GO:0035256]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of interleukin-2 production [GO:0032703]; protein targeting [GO:0006605]; regulation of store-operated calcium entry [GO:2001256]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.
Q9NSC7	reviewed	SIA7A_HUMAN	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.3.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (ST6GalNAc-I) (ST6GalNAcI) (hST6GalNAc-I) (Sialyltransferase 7A) (SIAT7-A)	ST6GALNAC1 SIAT7A UNQ543/PRO848	Homo sapiens (Human)	600	FUNCTION: Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis (PubMed:35303419). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins (PubMed:16319059, PubMed:35303419). Catalyzes the formation of the sialyl-Tn (S-Tn) antigen, an antigen found in intestinal goblet cells, as well as ulcerative colitis (UC) and various cancers (PubMed:16319059, PubMed:35303419). Protein sialylation in globlet cells is essential for mucus integrity and is required to protect the intestinal mucus against excessive bacterial proteolytic degradation (PubMed:35303419). {ECO:0000269|PubMed:16319059, ECO:0000269|PubMed:35303419}.		host-mediated regulation of intestinal microbiota composition [GO:0048874]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]	Golgi membrane [GO:0000139]	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; sialyltransferase activity [GO:0008373]	Golgi membrane [GO:0000139]; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; sialyltransferase activity [GO:0008373]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16319059, ECO:0000269|PubMed:35303419}; Single-pass type II membrane protein {ECO:0000305}.
Q9NSD4	reviewed	ZN275_HUMAN	Zinc finger protein 275	ZNF275	Homo sapiens (Human)	429	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NSD5	reviewed	S6A13_HUMAN	Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13)	SLC6A13 GAT2	Homo sapiens (Human)	602	FUNCTION: Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:17502375, PubMed:22932902). Mediates transport of beta-alanine (PubMed:17502375). Can also mediate transport of taurine and hypotaurine (By similarity). {ECO:0000250|UniProtKB:P31649, ECO:0000269|PubMed:17502375, ECO:0000269|PubMed:22932902}.		amino acid import across plasma membrane [GO:0089718]; creatine transmembrane transport [GO:0015881]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid reuptake [GO:0051936]; monocarboxylic acid transport [GO:0015718]; nitrogen compound transport [GO:0071705]; sodium ion transmembrane transport [GO:0035725]; taurine transport [GO:0015734]; transport across blood-brain barrier [GO:0150104]	basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; creatine transmembrane transporter activity [GO:0005308]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369]	basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; creatine transmembrane transporter activity [GO:0005308]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369]; amino acid import across plasma membrane [GO:0089718]; creatine transmembrane transport [GO:0015881]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid reuptake [GO:0051936]; monocarboxylic acid transport [GO:0015718]; nitrogen compound transport [GO:0071705]; sodium ion transmembrane transport [GO:0035725]; taurine transport [GO:0015734]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22932902}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P31649}; Multi-pass membrane protein {ECO:0000255}.
Q9NSD9	reviewed	SYFB_HUMAN	Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS)	FARSB FARSLB FRSB HSPC173	Homo sapiens (Human)	589			phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phenylalanine-tRNA ligase complex [GO:0009328]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phenylalanine-tRNA ligase complex [GO:0009328]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723]; phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:29573043}.
Q9NSE2	reviewed	CISH_HUMAN	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)	CISH G18	Homo sapiens (Human)	258	FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.		intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein ubiquitination [GO:0016567]; regulation of cell growth [GO:0001558]	cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]	cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein ubiquitination [GO:0016567]; regulation of cell growth [GO:0001558]	
Q9NSE4	reviewed	SYIM_HUMAN	Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)	IARS2	Homo sapiens (Human)	1012			isoleucyl-tRNA aminoacylation [GO:0006428]; mitochondrial translation [GO:0032543]; tRNA aminoacylation for protein translation [GO:0006418]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049]; isoleucyl-tRNA aminoacylation [GO:0006428]; mitochondrial translation [GO:0032543]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
Q9NSG2	reviewed	FIRRM_HUMAN	FIGNL1-interacting regulator of recombination and mitosis (FIDGETIN-like-1 interacting protein) (FLIP) (POLO1-associating protein)	FIRRM APOLO1 C1orf112	Homo sapiens (Human)	853	FUNCTION: Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities (PubMed:34260926). Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis (PubMed:34260926). In complex with FIGL1 may regulate homologous recombination (PubMed:29608566). {ECO:0000269|PubMed:29608566, ECO:0000269|PubMed:34260926}.		chromosome segregation [GO:0007059]; interstrand cross-link repair [GO:0036297]; mitotic cell cycle [GO:0000278]; regulation of protein kinase activity [GO:0045859]	chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle midzone [GO:0051233]	protein kinase binding [GO:0019901]	chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle midzone [GO:0051233]; protein kinase binding [GO:0019901]; chromosome segregation [GO:0007059]; interstrand cross-link repair [GO:0036297]; mitotic cell cycle [GO:0000278]; regulation of protein kinase activity [GO:0045859]	SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:34260926}. Nucleus {ECO:0000269|PubMed:34260926}. Chromosome, centromere {ECO:0000269|PubMed:34260926}. Midbody {ECO:0000269|PubMed:34260926}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:34260926}. Note=Exhibits cell-cycle-dependent distribution during mitosis. Detected in the nucleus in interphase. Colocalizes with PLK1 to the centromeres in a nearby prometaphase cells. Relocates to the central spindle in anaphase and to the midbody in telophase cells. {ECO:0000269|PubMed:34260926}.
Q9NSI6	reviewed	BRWD1_HUMAN	Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9)	BRWD1 C21orf107 WDR9	Homo sapiens (Human)	2320	FUNCTION: May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.		cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q921C3}. Nucleus {ECO:0000269|PubMed:25593309}.
Q9NSI8	reviewed	SAMN1_HUMAN	SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein)	SAMSN1 HACS1	Homo sapiens (Human)	373	FUNCTION: Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity). {ECO:0000250, ECO:0000269|PubMed:15381729}.		negative regulation of adaptive immune response [GO:0002820]; negative regulation of B cell activation [GO:0050869]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ruffle [GO:0001726]	phosphotyrosine residue binding [GO:0001784]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ruffle [GO:0001726]; phosphotyrosine residue binding [GO:0001784]; RNA binding [GO:0003723]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of B cell activation [GO:0050869]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11594764}. Cytoplasm {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles (By similarity). {ECO:0000250}.
Q9NSK0	reviewed	KLC4_HUMAN	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8)	KLC4 KNSL8	Homo sapiens (Human)	619	FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	microtubule-based movement [GO:0007018]	cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]	kinesin binding [GO:0019894]	cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; kinesin binding [GO:0019894]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
Q9NSK7	reviewed	CS012_HUMAN	Protein C19orf12	C19orf12	Homo sapiens (Human)	152			apoptotic process [GO:0006915]; autophagy [GO:0006914]; mitochondrial calcium ion homeostasis [GO:0051560]; response to oxidative stress [GO:0006979]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; apoptotic process [GO:0006915]; autophagy [GO:0006914]; mitochondrial calcium ion homeostasis [GO:0051560]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21981780, ECO:0000269|PubMed:22508347, ECO:0000269|PubMed:26136767}. Mitochondrion membrane {ECO:0000269|PubMed:21981780, ECO:0000269|PubMed:26136767}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:22508347}. Cytoplasm, cytosol {ECO:0000269|PubMed:26136767}. Note=In response to oxidative stress, relocates to the cytosol forming aggregates that partially co-localize with mitochondria. {ECO:0000269|PubMed:26136767}.
Q9NSN8	reviewed	SNTG1_HUMAN	Gamma-1-syntrophin (G1SYN) (Syntrophin-4) (SYN4)	SNTG1	Homo sapiens (Human)	517	FUNCTION: Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation. {ECO:0000250}.		cell communication [GO:0007154]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; syntrophin complex [GO:0016013]	actin binding [GO:0003779]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; syntrophin complex [GO:0016013]; actin binding [GO:0003779]; structural molecule activity [GO:0005198]; cell communication [GO:0007154]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Nucleus. Note=Mainly cytoplasmic and weakly nuclear.
Q9NSP4	reviewed	CENPM_HUMAN	Centromere protein M (CENP-M) (Interphase centromere complex protein 39) (Proliferation-associated nuclear element protein 1)	CENPM C22orf18 ICEN39 PANE1	Homo sapiens (Human)	180	FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. {ECO:0000269|PubMed:16716197}.	MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.	chromosome segregation [GO:0007059]	cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromosome segregation [GO:0007059]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres. {ECO:0000250}.
Q9NST1	reviewed	PLPL3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (EC 2.3.1.51) (Acylglycerol transacylase) (Adiponutrin) (ADPN) (Calcium-independent phospholipase A2-epsilon) (iPLA2-epsilon) (EC 3.1.1.4) (Lysophosphatidic acid acyltransferase) (Patatin-like phospholipase domain-containing protein 3) (EC 3.1.1.3)	PNPLA3 ADPN C22orf20	Homo sapiens (Human)	481	FUNCTION: Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221). In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety (PubMed:21878620). However, the triacylglycerol hydrolase activity is controversial and may be very low (PubMed:22560221). Possesses phospholipase A2 activity (PubMed:15364929). {ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:20034933, ECO:0000269|PubMed:21878620, ECO:0000269|PubMed:22560221}.		acylglycerol acyl-chain remodeling [GO:0036155]; cellular response to 3,3',5-triiodo-L-thyronine [GO:1905243]; cellular response to insulin stimulus [GO:0032869]; glycerophospholipid metabolic process [GO:0006650]; lipid droplet organization [GO:0034389]; lipid homeostasis [GO:0055088]; long-chain fatty acid metabolic process [GO:0001676]; phosphatidic acid biosynthetic process [GO:0006654]; response to sucrose [GO:0009744]; triglyceride acyl-chain remodeling [GO:0036153]; triglyceride biosynthetic process [GO:0019432]; triglyceride catabolic process [GO:0019433]; white fat cell differentiation [GO:0050872]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acylglycerol O-acyltransferase activity [GO:0016411]; diolein transacylation activity [GO:0051265]; lipoprotein lipase activity [GO:0004465]; long-chain fatty acyl-CoA binding [GO:0036042]; lysophosphatidic acid acyltransferase activity [GO:0042171]; lysophosphatidic acid binding [GO:0035727]; mono-olein transacylation activity [GO:0051264]; phospholipase A2 activity [GO:0004623]; triglyceride lipase activity [GO:0004806]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acylglycerol O-acyltransferase activity [GO:0016411]; diolein transacylation activity [GO:0051265]; lipoprotein lipase activity [GO:0004465]; long-chain fatty acyl-CoA binding [GO:0036042]; lysophosphatidic acid acyltransferase activity [GO:0042171]; lysophosphatidic acid binding [GO:0035727]; mono-olein transacylation activity [GO:0051264]; phospholipase A2 activity [GO:0004623]; triglyceride lipase activity [GO:0004806]; acylglycerol acyl-chain remodeling [GO:0036155]; cellular response to 3,3',5-triiodo-L-thyronine [GO:1905243]; cellular response to insulin stimulus [GO:0032869]; glycerophospholipid metabolic process [GO:0006650]; lipid droplet organization [GO:0034389]; lipid homeostasis [GO:0055088]; long-chain fatty acid metabolic process [GO:0001676]; phosphatidic acid biosynthetic process [GO:0006654]; response to sucrose [GO:0009744]; triglyceride acyl-chain remodeling [GO:0036153]; triglyceride biosynthetic process [GO:0019432]; triglyceride catabolic process [GO:0019433]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:22560221}; Single-pass type II membrane protein {ECO:0000269|PubMed:15364929}. Lipid droplet {ECO:0000269|PubMed:20034933, ECO:0000269|PubMed:22560221}.
Q9NSU2	reviewed	TREX1_HUMAN	Three-prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (Deoxyribonuclease III) (DNase III)	TREX1	Homo sapiens (Human)	314	FUNCTION: Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini (PubMed:10391904, PubMed:10393201, PubMed:17293595). Prevents cell-intrinsic initiation of autoimmunity (PubMed:10391904, PubMed:10393201, PubMed:17293595). Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements (PubMed:10391904, PubMed:10393201, PubMed:17293595). Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation (PubMed:33476576). Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation (PubMed:33476576). Unless degraded, these DNA fragments accumulate in the cytosol and activate the cGAS-STING innate immune signaling, leading to the production of type I interferon (PubMed:33476576). Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates (PubMed:18045533). Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light (PubMed:23993650). During GZMA-mediated cell death, contributes to DNA damage in concert with NME1 (PubMed:16818237). NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (PubMed:16818237). {ECO:0000269|PubMed:10391904, ECO:0000269|PubMed:10393201, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:17293595, ECO:0000269|PubMed:18045533, ECO:0000269|PubMed:23993650, ECO:0000269|PubMed:33476576}.		activation of immune response [GO:0002253]; apoptotic cell clearance [GO:0043277]; atrial cardiac muscle tissue development [GO:0003228]; blood vessel development [GO:0001568]; CD86 biosynthetic process [GO:0035781]; cellular response to gamma radiation [GO:0071480]; cellular response to hydroxyurea [GO:0072711]; cellular response to interferon-beta [GO:0035458]; cellular response to reactive oxygen species [GO:0034614]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; DNA catabolic process [GO:0006308]; DNA duplex unwinding [GO:0032508]; DNA metabolic process [GO:0006259]; DNA modification [GO:0006304]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA synthesis involved in UV-damage excision repair [GO:1904161]; establishment of protein localization [GO:0045184]; generation of precursor metabolites and energy [GO:0006091]; heart morphogenesis [GO:0003007]; heart process [GO:0003015]; immune complex formation [GO:0097281]; immune response in brain or nervous system [GO:0002383]; inflammatory response to antigenic stimulus [GO:0002437]; kidney development [GO:0001822]; lymphoid progenitor cell differentiation [GO:0002320]; macrophage activation involved in immune response [GO:0002281]; mismatch repair [GO:0006298]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of innate immune response [GO:0045824]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein stabilization [GO:0050821]; regulation of cellular respiration [GO:0043457]; regulation of fatty acid metabolic process [GO:0019217]; regulation of glycolytic process [GO:0006110]; regulation of immunoglobulin production [GO:0002637]; regulation of inflammatory response [GO:0050727]; regulation of lipid biosynthetic process [GO:0046890]; regulation of lysosome organization [GO:1905671]; regulation of protein complex stability [GO:0061635]; regulation of T cell activation [GO:0050863]; regulation of tumor necrosis factor production [GO:0032680]; regulation of type I interferon production [GO:0032479]; retrotransposition [GO:0032197]; T cell antigen processing and presentation [GO:0002457]; type I interferon-mediated signaling pathway [GO:0060337]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear replication fork [GO:0043596]; oligosaccharyltransferase complex [GO:0008250]; protein-DNA complex [GO:0032993]	3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; adenyl deoxyribonucleotide binding [GO:0032558]; DNA binding, bending [GO:0008301]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; double-stranded DNA binding [GO:0003690]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; MutLalpha complex binding [GO:0032405]; MutSalpha complex binding [GO:0032407]; protein homodimerization activity [GO:0042803]; single-stranded DNA binding [GO:0003697]; WW domain binding [GO:0050699]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear replication fork [GO:0043596]; oligosaccharyltransferase complex [GO:0008250]; protein-DNA complex [GO:0032993]; 3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; adenyl deoxyribonucleotide binding [GO:0032558]; DNA binding, bending [GO:0008301]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; double-stranded DNA binding [GO:0003690]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; MutLalpha complex binding [GO:0032405]; MutSalpha complex binding [GO:0032407]; protein homodimerization activity [GO:0042803]; single-stranded DNA binding [GO:0003697]; WW domain binding [GO:0050699]; activation of immune response [GO:0002253]; apoptotic cell clearance [GO:0043277]; atrial cardiac muscle tissue development [GO:0003228]; blood vessel development [GO:0001568]; CD86 biosynthetic process [GO:0035781]; cellular response to gamma radiation [GO:0071480]; cellular response to hydroxyurea [GO:0072711]; cellular response to interferon-beta [GO:0035458]; cellular response to reactive oxygen species [GO:0034614]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; DNA catabolic process [GO:0006308]; DNA duplex unwinding [GO:0032508]; DNA metabolic process [GO:0006259]; DNA modification [GO:0006304]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA synthesis involved in UV-damage excision repair [GO:1904161]; establishment of protein localization [GO:0045184]; generation of precursor metabolites and energy [GO:0006091]; heart morphogenesis [GO:0003007]; heart process [GO:0003015]; immune complex formation [GO:0097281]; immune response in brain or nervous system [GO:0002383]; inflammatory response to antigenic stimulus [GO:0002437]; kidney development [GO:0001822]; lymphoid progenitor cell differentiation [GO:0002320]; macrophage activation involved in immune response [GO:0002281]; mismatch repair [GO:0006298]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of innate immune response [GO:0045824]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein stabilization [GO:0050821]; regulation of cellular respiration [GO:0043457]; regulation of fatty acid metabolic process [GO:0019217]; regulation of glycolytic process [GO:0006110]; regulation of immunoglobulin production [GO:0002637]; regulation of inflammatory response [GO:0050727]; regulation of lipid biosynthetic process [GO:0046890]; regulation of lysosome organization [GO:1905671]; regulation of protein complex stability [GO:0061635]; regulation of T cell activation [GO:0050863]; regulation of tumor necrosis factor production [GO:0032680]; regulation of type I interferon production [GO:0032479]; retrotransposition [GO:0032197]; T cell antigen processing and presentation [GO:0002457]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10393201}. Cytoplasm, cytosol {ECO:0000269|PubMed:16818237}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:33476576}; Peripheral membrane protein {ECO:0000269|PubMed:33476576}. Note=Retained in the cytoplasm through the C-terminal region (By similarity). Localization to the endoplasmic reticulum membrane is required to direct TREX1 to ruptured micronuclei (PubMed:33476576). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci (PubMed:16818237). Translocation to the nucleus also occurs during GZMA-mediated cell death (PubMed:16818237). {ECO:0000250|UniProtKB:Q91XB0, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:33476576}.
Q9NSV4	reviewed	DIAP3_HUMAN	Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2)	DIAPH3 DIAP3	Homo sapiens (Human)	1193	FUNCTION: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. {ECO:0000250|UniProtKB:Q9Z207}.		actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; cytoskeleton organization [GO:0007010]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	actin binding [GO:0003779]; cadherin binding [GO:0045296]; small GTPase binding [GO:0031267]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; cytoskeleton organization [GO:0007010]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18755006, ECO:0000269|PubMed:19457867}. Nucleus {ECO:0000250|UniProtKB:Q9Z207}. Note=During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis (PubMed:18755006, PubMed:19457867). Shuttles between the cytoplasm and the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9Z207, ECO:0000269|PubMed:18755006, ECO:0000269|PubMed:19457867}.
Q9NSY1	reviewed	BMP2K_HUMAN	BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1)	BMP2K BIKE HRIHFB2017	Homo sapiens (Human)	1161	FUNCTION: May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}.		phosphorylation [GO:0016310]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of bone mineralization [GO:0030500]; regulation of clathrin-dependent endocytosis [GO:2000369]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; phosphatase regulator activity [GO:0019208]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; phosphatase regulator activity [GO:0019208]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of bone mineralization [GO:0030500]; regulation of clathrin-dependent endocytosis [GO:2000369]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9853615}.
Q9NT22	reviewed	EMIL3_HUMAN	EMILIN-3 (EMILIN-5) (Elastin microfibril interface-located protein 3) (Elastin microfibril interfacer 3) (Elastin microfibril interface-located protein 5) (Elastin microfibril interfacer 5)	EMILIN3 C20orf130 EMILIN5	Homo sapiens (Human)	766				collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]	extracellular matrix constituent conferring elasticity [GO:0030023]; identical protein binding [GO:0042802]	collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular matrix constituent conferring elasticity [GO:0030023]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q9NT62	reviewed	ATG3_HUMAN	Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96)	ATG3 APG3 APG3L	Homo sapiens (Human)	314	FUNCTION: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. {ECO:0000269|PubMed:11825910, ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:12890687, ECO:0000269|PubMed:16704426, ECO:0000269|PubMed:20723759}.		autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; negative regulation of phagocytosis [GO:0050765]; nucleophagy [GO:0044804]; protein targeting to membrane [GO:0006612]; protein ubiquitination [GO:0016567]; regulation of cilium assembly [GO:1902017]	Atg12-Atg5-Atg16 complex [GO:0034274]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]	Atg12 transferase activity [GO:0019777]; Atg8-family ligase activity [GO:0019776]; enzyme binding [GO:0019899]; ubiquitin-like protein conjugating enzyme activity [GO:0061650]; ubiquitin-like protein transferase activity [GO:0019787]	Atg12-Atg5-Atg16 complex [GO:0034274]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; Atg12 transferase activity [GO:0019777]; Atg8-family ligase activity [GO:0019776]; enzyme binding [GO:0019899]; ubiquitin-like protein conjugating enzyme activity [GO:0061650]; ubiquitin-like protein transferase activity [GO:0019787]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; negative regulation of phagocytosis [GO:0050765]; nucleophagy [GO:0044804]; protein targeting to membrane [GO:0006612]; protein ubiquitination [GO:0016567]; regulation of cilium assembly [GO:1902017]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11825910}.
Q9NT68	reviewed	TEN2_HUMAN	Teneurin-2 (Ten-2) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)]	TENM2 KIAA1127 ODZ2 TNM2	Homo sapiens (Human)	2774	FUNCTION: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. {ECO:0000250, ECO:0000269|PubMed:21724987}.; FUNCTION: [Isoform 2]: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion. {ECO:0000269|PubMed:21724987}.; FUNCTION: [Ten-2 intracellular domain]: Induces gene transcription inhibition. {ECO:0000250}.		axon guidance [GO:0007411]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell-cell adhesion [GO:0098609]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; positive regulation of filopodium assembly [GO:0051491]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; signal transduction [GO:0007165]	cell junction [GO:0030054]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]	cell junction [GO:0030054]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; axon guidance [GO:0007411]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell-cell adhesion [GO:0098609]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; positive regulation of filopodium assembly [GO:0051491]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Synapse {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=Colocalizes with ADGRL1 across intercellular junctions. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane. Note=Colocalizes with ADGRL1 across intercellular junctions.; SUBCELLULAR LOCATION: [Ten-2 intracellular domain]: Nucleus, PML body {ECO:0000250}.
Q9NT99	reviewed	LRC4B_HUMAN	Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3)	LRRC4B LRIG4	Homo sapiens (Human)	713	FUNCTION: Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity). {ECO:0000250}.		positive regulation of synapse assembly [GO:0051965]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]	cerebellar mossy fiber [GO:0044300]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]	signaling receptor binding [GO:0005102]	cerebellar mossy fiber [GO:0044300]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; signaling receptor binding [GO:0005102]; positive regulation of synapse assembly [GO:0051965]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein. Presynaptic cell membrane {ECO:0000250}.
Q9NTG1	reviewed	PKDRE_HUMAN	Polycystin family receptor for egg jelly (PKD and REJ homolog) (Polycystic kidney disease and receptor for egg jelly-related protein)	PKDREJ	Homo sapiens (Human)	2253	FUNCTION: May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm.		acrosome reaction [GO:0007340]; detection of mechanical stimulus [GO:0050982]	membrane [GO:0016020]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]	membrane [GO:0016020]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; acrosome reaction [GO:0007340]; detection of mechanical stimulus [GO:0050982]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NTG7	reviewed	SIR3_HUMAN	NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3)	SIRT3 SIR2L3	Homo sapiens (Human)	399	FUNCTION: NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity). Regulates hepatic lipogenesis. Uses NAD(+) substrate imported by SLC25A47, triggering downstream activation of PRKAA1/AMPK-alpha signaling cascade that ultimately downregulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. {ECO:0000250|UniProtKB:Q8R104, ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:24121500, ECO:0000269|PubMed:24252090}.	MISCELLANEOUS: Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is unlikely in vivo. {ECO:0000269|PubMed:12374852}.	aerobic respiration [GO:0009060]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of catalase activity [GO:1902553]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of insulin secretion [GO:0032024]; positive regulation of superoxide dismutase activity [GO:1901671]; protein deacetylation [GO:0006476]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	enzyme binding [GO:0019899]; NAD+ binding [GO:0070403]; NAD-dependent histone deacetylase activity [GO:0017136]; NAD-dependent protein deacetylase activity [GO:0034979]; sequence-specific DNA binding [GO:0043565]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; enzyme binding [GO:0019899]; NAD+ binding [GO:0070403]; NAD-dependent histone deacetylase activity [GO:0017136]; NAD-dependent protein deacetylase activity [GO:0034979]; sequence-specific DNA binding [GO:0043565]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; aerobic respiration [GO:0009060]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of catalase activity [GO:1902553]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of insulin secretion [GO:0032024]; positive regulation of superoxide dismutase activity [GO:1901671]; protein deacetylation [GO:0006476]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18215119, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:29445193}.
Q9NTI2	reviewed	AT8A2_HUMAN	Phospholipid-transporting ATPase IB (EC 7.6.2.1) (ATPase class I type 8A member 2) (ML-1) (P4-ATPase flippase complex alpha subunit ATP8A2)	ATP8A2 ATPIB	Homo sapiens (Human)	1188	FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (By similarity). Able to translocate phosphatidylserine, but not phosphatidylcholine (PubMed:34403372). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (By similarity). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (By similarity). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth (By similarity). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes (By similarity). May be involved in vesicle trafficking in neuronal cells (By similarity). Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival (By similarity). {ECO:0000250|UniProtKB:C7EXK4, ECO:0000269|PubMed:34403372, ECO:0000305|PubMed:31397519}.		aminophospholipid translocation [GO:0140331]; axonogenesis [GO:0007409]; detection of light stimulus involved in visual perception [GO:0050908]; determination of adult lifespan [GO:0008340]; eating behavior [GO:0042755]; inner ear morphogenesis [GO:0042472]; involuntary skeletal muscle contraction [GO:0003011]; negative regulation of cell population proliferation [GO:0008285]; neurofilament cytoskeleton organization [GO:0060052]; neuromuscular process controlling posture [GO:0050884]; neuron development [GO:0048666]; phospholipid translocation [GO:0045332]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phospholipid translocation [GO:0061092]; response to auditory stimulus [GO:0010996]; retina layer formation [GO:0010842]; skin development [GO:0043588]	cell projection [GO:0042995]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556]	cell projection [GO:0042995]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556]; aminophospholipid translocation [GO:0140331]; axonogenesis [GO:0007409]; detection of light stimulus involved in visual perception [GO:0050908]; determination of adult lifespan [GO:0008340]; eating behavior [GO:0042755]; inner ear morphogenesis [GO:0042472]; involuntary skeletal muscle contraction [GO:0003011]; negative regulation of cell population proliferation [GO:0008285]; neurofilament cytoskeleton organization [GO:0060052]; neuromuscular process controlling posture [GO:0050884]; neuron development [GO:0048666]; phospholipid translocation [GO:0045332]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phospholipid translocation [GO:0061092]; response to auditory stimulus [GO:0010996]; retina layer formation [GO:0010842]; skin development [GO:0043588]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:20947505}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:20947505}. Endosome membrane {ECO:0000250|UniProtKB:P98200}. Cell membrane {ECO:0000269|PubMed:20947505}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P98200}. Photoreceptor inner segment membrane {ECO:0000250|UniProtKB:C7EXK4}. Note=Localizes to the Golgi and endosomes in photoreceptor cells (By similarity). Localizes to disk membranes of rod photoreceptor outer segments (ROS) (By similarity). {ECO:0000250|UniProtKB:C7EXK4, ECO:0000250|UniProtKB:P98200}.
Q9NTI5	reviewed	PDS5B_HUMAN	Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3)	PDS5B APRIN AS3 KIAA0979	Homo sapiens (Human)	1447	FUNCTION: Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}.		cell division [GO:0051301]; cell population proliferation [GO:0008283]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell population proliferation [GO:0042127]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6TRW4}.
Q9NTJ3	reviewed	SMC4_HUMAN	Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog)	SMC4 CAPC SMC4L1	Homo sapiens (Human)	1288	FUNCTION: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.		cell division [GO:0051301]; kinetochore organization [GO:0051383]; meiotic chromosome condensation [GO:0010032]; meiotic chromosome segregation [GO:0045132]; mitotic chromosome condensation [GO:0007076]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	chromosome, centromeric region [GO:0000775]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; single-stranded DNA binding [GO:0003697]	chromosome, centromeric region [GO:0000775]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; single-stranded DNA binding [GO:0003697]; cell division [GO:0051301]; kinetochore organization [GO:0051383]; meiotic chromosome condensation [GO:0010032]; meiotic chromosome segregation [GO:0045132]; mitotic chromosome condensation [GO:0007076]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Q9NTJ4	reviewed	MA2C1_HUMAN	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha mannosidase 6A8B) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1)	MAN2C1 MANA MANA1	Homo sapiens (Human)	1040	FUNCTION: Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues on cytoplasmatic free oligosaccharides generated by N-glycoprotein degradation pathways. {ECO:0000269|PubMed:16848760}.		mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16848760}.
Q9NTJ5	reviewed	SAC1_HUMAN	Phosphatidylinositol-3-phosphatase SAC1 (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Suppressor of actin mutations 1-like protein)	SACM1L KIAA0851 SAC1	Homo sapiens (Human)	587	FUNCTION: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:24209621, PubMed:27044890, PubMed:29461204, PubMed:30659099). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (PubMed:29461204, PubMed:24209621, PubMed:30659099). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (PubMed:30659099). {ECO:0000250|UniProtKB:Q9ES21, ECO:0000269|PubMed:24209621, ECO:0000269|PubMed:27044890, ECO:0000269|PubMed:29461204, ECO:0000269|PubMed:30659099}.		phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	phosphatase activity [GO:0016791]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; phosphatase activity [GO:0016791]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27044890, ECO:0000269|PubMed:29461204, ECO:0000269|PubMed:31806350}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:29461204, ECO:0000269|PubMed:31806350}. Note=Trafficking between the ER and Golgi is regulated by nutrient status and by TMEM39A (PubMed:31806350). Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) in the presence of phosphatidylinositol-4,5-bisphosphate (PubMed:27044890). {ECO:0000269|PubMed:27044890, ECO:0000269|PubMed:31806350}.
Q9NTK1	reviewed	DEPP1_HUMAN	Protein DEPP1 (Decidual protein induced by progesterone) (Fasting-induced gene protein) (FIG)	DEPP1 C10orf10 DEPP FIG	Homo sapiens (Human)	212	FUNCTION: Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS. {ECO:0000269|PubMed:24530860, ECO:0000269|PubMed:25261981, ECO:0000269|PubMed:28545464}.		autophagy [GO:0006914]; regulation of autophagy [GO:0010506]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]		cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]; autophagy [GO:0006914]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24530860, ECO:0000269|PubMed:25261981}. Peroxisome {ECO:0000269|PubMed:25261981}. Mitochondrion {ECO:0000269|PubMed:25261981}. Note=May localize to aggresomes (PubMed:24530860). {ECO:0000269|PubMed:24530860}.
Q9NTK5	reviewed	OLA1_HUMAN	Obg-like ATPase 1 (DNA damage-regulated overexpressed in cancer 45) (DOC45) (GTP-binding protein 9)	OLA1 GTPBP9 PRO2455 PTD004	Homo sapiens (Human)	396	FUNCTION: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. {ECO:0000255|HAMAP-Rule:MF_03167}.		ATP metabolic process [GO:0046034]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; platelet alpha granule lumen [GO:0031093]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; ribosomal large subunit binding [GO:0043023]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; platelet alpha granule lumen [GO:0031093]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; ribosomal large subunit binding [GO:0043023]; ATP metabolic process [GO:0046034]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:20053727}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:20053727}. Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:20053727}. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm. {ECO:0000255|HAMAP-Rule:MF_03167}.
Q9NTM9	reviewed	CUTC_HUMAN	Copper homeostasis protein cutC homolog	CUTC CGI-32	Homo sapiens (Human)	273	FUNCTION: May play a role in copper homeostasis. Can bind one Cu(1+) per subunit. {ECO:0000269|PubMed:16182249, ECO:0000269|PubMed:19878721}.		copper ion homeostasis [GO:0055070]; copper ion transport [GO:0006825]; protein tetramerization [GO:0051262]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	copper ion binding [GO:0005507]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; copper ion binding [GO:0005507]; copper ion homeostasis [GO:0055070]; copper ion transport [GO:0006825]; protein tetramerization [GO:0051262]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16182249}. Nucleus {ECO:0000269|PubMed:16182249}. Note=The overexpressed protein is detected in the cytoplasm, and depending on the cell line, also in the nucleus.
Q9NTN3	reviewed	S35D1_HUMAN	Nucleotide sugar transporter SLC35D1 (Solute carrier family 35 member D1) (UDP-galactose transporter-related protein 7) (UGTrel7) (UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter) (UDP-GlcA/UDP-GalNAc transporter)	SLC35D1 KIAA0260 UGTREL7	Homo sapiens (Human)	355	FUNCTION: Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for either their cognate nucleoside monophosphate or another nucleotide sugar (PubMed:16965264, PubMed:17599910, PubMed:31423530). Transports various UDP-sugars including UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc), UDP-N-acetyl-alpha-D-galactosamine (UDP-GalNAc) and UDP-alpha-D-glucuronate (UDP-GlcA), which are used by ER glucosyltransferases as sugar donors for the synthesis of sugar chains of glycoproteins, glycolipids and oligosaccharides (PubMed:11322953, PubMed:16965264, PubMed:17599910, PubMed:31423530, PubMed:17952091). May couple UDP-GlcNAc or UDP-GalNAc efflux to UDP-GlcA influx into the ER lumen that in turn stimulates glucuronidation and subsequent excretion of endobiotics and xenobiotics (PubMed:16965264, PubMed:17599910). Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity). {ECO:0000250|UniProtKB:A2AKQ0, ECO:0000269|PubMed:11322953, ECO:0000269|PubMed:16965264, ECO:0000269|PubMed:17599910, ECO:0000269|PubMed:17952091, ECO:0000269|PubMed:31423530}.		carbohydrate transport [GO:0008643]; pyrimidine nucleotide-sugar transmembrane transport [GO:0090481]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	antiporter activity [GO:0015297]; GDP-fucose transmembrane transporter activity [GO:0005457]; UDP-glucuronic acid transmembrane transporter activity [GO:0005461]; UDP-N-acetylgalactosamine transmembrane transporter activity [GO:0005463]; UDP-N-acetylglucosamine transmembrane transporter activity [GO:0005462]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; antiporter activity [GO:0015297]; GDP-fucose transmembrane transporter activity [GO:0005457]; UDP-glucuronic acid transmembrane transporter activity [GO:0005461]; UDP-N-acetylgalactosamine transmembrane transporter activity [GO:0005463]; UDP-N-acetylglucosamine transmembrane transporter activity [GO:0005462]; carbohydrate transport [GO:0008643]; pyrimidine nucleotide-sugar transmembrane transport [GO:0090481]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11322953}; Multi-pass membrane protein {ECO:0000255}.
Q9NTN9	reviewed	SEM4G_HUMAN	Semaphorin-4G	SEMA4G KIAA1619	Homo sapiens (Human)	838	FUNCTION: Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	plasma membrane [GO:0005886]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	plasma membrane [GO:0005886]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q9NTQ9	reviewed	CXB4_HUMAN	Gap junction beta-4 protein (Connexin-30.3) (Cx30.3)	GJB4	Homo sapiens (Human)	266	FUNCTION: Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity). {ECO:0000250|UniProtKB:P29033, ECO:0000250|UniProtKB:Q02738}.		cell-cell signaling [GO:0007267]; gap junction-mediated intercellular transport [GO:1990349]; olfactory behavior [GO:0042048]; sensory perception of smell [GO:0007608]	cell junction [GO:0030054]; connexin complex [GO:0005922]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	gap junction channel activity [GO:0005243]	cell junction [GO:0030054]; connexin complex [GO:0005922]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; gap junction channel activity [GO:0005243]; cell-cell signaling [GO:0007267]; gap junction-mediated intercellular transport [GO:1990349]; olfactory behavior [GO:0042048]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q02738}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q02738}. Cell junction, gap junction {ECO:0000250|UniProtKB:Q02738}. Note=Colocalizes with GJB2 at gap junction plaques in the cochlea. {ECO:0000250|UniProtKB:Q02738}.
Q9NTW7	reviewed	ZF64B_HUMAN	Zinc finger protein 64 (Zfp-64) (Zinc finger protein 338)	ZFP64 ZNF338	Homo sapiens (Human)	645	FUNCTION: May be involved in the regulation of mesenchymal cell differentiation through transactivation of NOTCH1 target genes. {ECO:0000250|UniProtKB:Q99KE8}.		mesenchymal cell differentiation [GO:0048762]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytoplasm [GO:0005737]; megasporocyte nucleus [GO:0043076]; nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; megasporocyte nucleus [GO:0043076]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; mesenchymal cell differentiation [GO:0048762]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27353377}.
Q9NTX7	reviewed	RN146_HUMAN	E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)	RNF146	Homo sapiens (Human)	359	FUNCTION: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation (PubMed:21478859, PubMed:21799911, PubMed:22267412). May regulate many important biological processes, such as cell survival and DNA damage response (PubMed:21825151, PubMed:22267412). Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex (PubMed:21478859, PubMed:21799911). Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2 (PubMed:21799911). Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation (PubMed:21799911). Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48' (PubMed:21799911). May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location (PubMed:21799911). Neuroprotective protein (PubMed:21602803). Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity). Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity). Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity). Promotes cell survival after gamma-irradiation (PubMed:21825151). Facilitates DNA repair (PubMed:21825151). {ECO:0000250|UniProtKB:Q9CZW6, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:21602803, ECO:0000269|PubMed:21799911, ECO:0000269|PubMed:21825151, ECO:0000269|PubMed:22267412}.	MISCELLANEOUS: Was named dactylidin after the Greek term 'daktylidi' for ring, 'the thing around the finger' (PubMed:15813938). Was named Iduna after the Norse goddess of protection and eternal youth (PubMed:21602803). {ECO:0000305|PubMed:15813938, ECO:0000305|PubMed:21602803}.	positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	poly-ADP-D-ribose binding [GO:0072572]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; poly-ADP-D-ribose binding [GO:0072572]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding.
Q9NTX9	reviewed	F217B_HUMAN	Protein FAM217B	FAM217B C20orf177	Homo sapiens (Human)	383				cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	
Q9NU19	reviewed	TB22B_HUMAN	TBC1 domain family member 22B	TBC1D22B C6orf197	Homo sapiens (Human)	505	FUNCTION: May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}.				14-3-3 protein binding [GO:0071889]; GTPase activator activity [GO:0005096]	14-3-3 protein binding [GO:0071889]; GTPase activator activity [GO:0005096]	
Q9NU22	reviewed	MDN1_HUMAN	Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein)	MDN1 KIAA0301	Homo sapiens (Human)	5596	FUNCTION: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). {ECO:0000250|UniProtKB:Q12019, ECO:0000269|PubMed:27814492}.		ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit export from nucleus [GO:0000055]	cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit export from nucleus [GO:0000055]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:22002106}. Nucleus, nucleoplasm {ECO:0000269|PubMed:26601951}. Cytoplasm {ECO:0000269|PubMed:26601951}.
Q9NU39	reviewed	FX4L1_HUMAN	Forkhead box protein D4-like 1 (FOXD4-like 1)	FOXD4L1	Homo sapiens (Human)	408			anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Q9NU63	reviewed	ZFP57_HUMAN	Zinc finger protein 57 homolog (Zfp-57) (Zinc finger protein 698)	ZFP57 C6orf40 ZNF698	Homo sapiens (Human)	452	FUNCTION: Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:18622393, PubMed:30602440). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). {ECO:0000250|UniProtKB:Q8C6P8, ECO:0000269|PubMed:18622393, ECO:0000269|PubMed:30602440}.		autosome genomic imprinting [GO:0141068]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; autosome genomic imprinting [GO:0141068]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30602440}. Note=Binds various differentially methylated regions (DMR). {ECO:0000269|PubMed:30602440}.
Q9NUB1	reviewed	ACS2L_HUMAN	Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1) (Propionate--CoA ligase) (EC 6.2.1.17)	ACSS1 ACAS2L KIAA1846	Homo sapiens (Human)	689	FUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity). {ECO:0000250|UniProtKB:Q99NB1, ECO:0000269|PubMed:16788062}.		acetate biosynthetic process [GO:0019413]; acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; ethanol oxidation [GO:0006069]; propionate biosynthetic process [GO:0019542]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	acetate-CoA ligase activity [GO:0003987]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; propionate-CoA ligase activity [GO:0050218]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; acetate-CoA ligase activity [GO:0003987]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; propionate-CoA ligase activity [GO:0050218]; acetate biosynthetic process [GO:0019413]; acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; ethanol oxidation [GO:0006069]; propionate biosynthetic process [GO:0019542]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:16788062}.
Q9NUD5	reviewed	ZCHC3_HUMAN	Zinc finger CCHC domain-containing protein 3	ZCCHC3 C20orf99	Homo sapiens (Human)	403	FUNCTION: Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIGI-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 (PubMed:30193849). {ECO:0000269|PubMed:30135424, ECO:0000269|PubMed:30193849}.		activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]	cytoplasm [GO:0005737]	double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30135424}.
Q9NUD9	reviewed	PIGV_HUMAN	GPI mannosyltransferase 2 (EC 2.4.1.-) (GPI mannosyltransferase II) (GPI-MT-II) (Phosphatidylinositol-glycan biosynthesis class V protein) (PIG-V)	PIGV	Homo sapiens (Human)	493	FUNCTION: Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. {ECO:0000269|PubMed:15623507, ECO:0000269|PubMed:15720390}.		GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]	endoplasmic reticulum membrane [GO:0005789]; mannosyltransferase complex [GO:0031501]; membrane [GO:0016020]	alpha-1,6-mannosyltransferase activity [GO:0000009]; glycolipid mannosyltransferase activity [GO:0004376]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum membrane [GO:0005789]; mannosyltransferase complex [GO:0031501]; membrane [GO:0016020]; alpha-1,6-mannosyltransferase activity [GO:0000009]; glycolipid mannosyltransferase activity [GO:0004376]; mannosyltransferase activity [GO:0000030]; GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15623507}; Multi-pass membrane protein {ECO:0000269|PubMed:15623507}.
Q9NUE0	reviewed	ZDH18_HUMAN	Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18)	ZDHHC18	Homo sapiens (Human)	388	FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269|PubMed:23034182, ECO:0000269|PubMed:27481942, ECO:0000269|PubMed:35438208}.		innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:35438208, ECO:0000305|PubMed:16647879}; Multi-pass membrane protein {ECO:0000255}.
Q9NUH8	reviewed	TM14B_HUMAN	Transmembrane protein 14B	TMEM14B	Homo sapiens (Human)	114	FUNCTION: Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions. {ECO:0000269|PubMed:29033352}.	MISCELLANEOUS: When expressed in embryonic mouse neocortex, induces intermediate progenitor cells and outer radial glia expansion, cortical thickening and induces gyrification (PubMed:29033352). {ECO:0000269|PubMed:29033352}.	cerebral cortex development [GO:0021987]; neural precursor cell proliferation [GO:0061351]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of heme biosynthetic process [GO:0070453]	mitochondrial membrane [GO:0031966]	identical protein binding [GO:0042802]	mitochondrial membrane [GO:0031966]; identical protein binding [GO:0042802]; cerebral cortex development [GO:0021987]; neural precursor cell proliferation [GO:0061351]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of heme biosynthetic process [GO:0070453]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q9NUI1	reviewed	DECR2_HUMAN	Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (pDCR) (EC 1.3.1.124) (2,4-dienoyl-CoA reductase 2) (Short chain dehydrogenase/reductase family 17C member 1)	DECR2 PDCR SDR17C1	Homo sapiens (Human)	292	FUNCTION: Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. {ECO:0000269|PubMed:11514237, ECO:0000269|PubMed:22745130}.		fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid metabolic process [GO:0006631]; unsaturated fatty acid biosynthetic process [GO:0006636]	cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	2,4-dienoyl-CoA reductase (NADPH) activity [GO:0008670]; trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166]	cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; 2,4-dienoyl-CoA reductase (NADPH) activity [GO:0008670]; trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid metabolic process [GO:0006631]; unsaturated fatty acid biosynthetic process [GO:0006636]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q9Z2M4}.
Q9NUJ1	reviewed	ABHDA_HUMAN	Palmitoyl-protein thioesterase ABHD10, mitochondrial (EC 3.1.2.22) (Acyl-protein thioesterase ABHD10) (Alpha/beta hydrolase domain-containing protein 10) (Abhydrolase domain-containing protein 10) (Mycophenolic acid acyl-glucuronide esterase, mitochondrial) (EC 3.1.1.93)	ABHD10	Homo sapiens (Human)	306	FUNCTION: Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins (PubMed:31740833). Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability (PubMed:31740833). Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate (PubMed:22294686). {ECO:0000269|PubMed:22294686, ECO:0000269|PubMed:31740833}.		cellular glucuronidation [GO:0052695]; glucuronoside catabolic process [GO:0019391]; protein depalmitoylation [GO:0002084]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; mycophenolic acid acyl-glucuronide esterase activity [GO:0102390]; palmitoyl-(protein) hydrolase activity [GO:0008474]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; mycophenolic acid acyl-glucuronide esterase activity [GO:0102390]; palmitoyl-(protein) hydrolase activity [GO:0008474]; cellular glucuronidation [GO:0052695]; glucuronoside catabolic process [GO:0019391]; protein depalmitoylation [GO:0002084]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:31740833}.
Q9NUJ3	reviewed	T11L1_HUMAN	T-complex protein 11-like protein 1	TCP11L1	Homo sapiens (Human)	509			signal transduction [GO:0007165]	microtubule [GO:0005874]		microtubule [GO:0005874]; signal transduction [GO:0007165]	
Q9NUK0	reviewed	MBNL3_HUMAN	Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR)	MBNL3 CHCR MBLX39 MBXL	Homo sapiens (Human)	354	FUNCTION: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. {ECO:0000269|PubMed:12297108, ECO:0000269|PubMed:15257297}.		mRNA processing [GO:0006397]; negative regulation of myoblast differentiation [GO:0045662]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; negative regulation of myoblast differentiation [GO:0045662]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11929853}. Cytoplasm {ECO:0000269|PubMed:11929853}. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
Q9NUL3	reviewed	STAU2_HUMAN	Double-stranded RNA-binding protein Staufen homolog 2	STAU2	Homo sapiens (Human)	570	FUNCTION: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250|UniProtKB:Q68SB1}.		anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; cellular response to oxidative stress [GO:0034599]; eye morphogenesis [GO:0048592]; germ cell development [GO:0007281]; intracellular mRNA localization [GO:0008298]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of filopodium assembly [GO:0051489]	axon [GO:0030424]; cytoplasmic stress granule [GO:0010494]; dendrite cytoplasm [GO:0032839]; dendritic shaft [GO:0043198]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; messenger ribonucleoprotein complex [GO:1990124]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	double-stranded RNA binding [GO:0003725]; Hsp70 protein binding [GO:0030544]; kinesin binding [GO:0019894]; mitogen-activated protein kinase binding [GO:0051019]; mRNA binding [GO:0003729]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]	axon [GO:0030424]; cytoplasmic stress granule [GO:0010494]; dendrite cytoplasm [GO:0032839]; dendritic shaft [GO:0043198]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; messenger ribonucleoprotein complex [GO:1990124]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; double-stranded RNA binding [GO:0003725]; Hsp70 protein binding [GO:0030544]; kinesin binding [GO:0019894]; mitogen-activated protein kinase binding [GO:0051019]; mRNA binding [GO:0003729]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; cellular response to oxidative stress [GO:0034599]; eye morphogenesis [GO:0048592]; germ cell development [GO:0007281]; intracellular mRNA localization [GO:0008298]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of filopodium assembly [GO:0051489]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity). {ECO:0000250}.
Q9NUL5	reviewed	SHFL_HUMAN	Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN)	SHFL C19orf66 FLJ11286 IRAV RYDEN SFL	Homo sapiens (Human)	291	FUNCTION: Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (PubMed:30682371). Regulates HIV1 GAG-POL expression by inhibiting -1PRF (PubMed:30682371). Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Interrupts also Zika virus replication by promoting viral NS3 degradation via a lysosome-dependent pathway (PubMed:32150556). Can also limit the replication of hepatitis C virus (HCV) by restricting formation of viral replication organelle, West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1), herpes virus type 8 (HHV-8) and human adenovirus (PubMed:26735137, PubMed:27974568, PubMed:30944177, PubMed:32294532). Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA (PubMed:27974568). {ECO:0000269|PubMed:26735137, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30682371, ECO:0000269|PubMed:30944177, ECO:0000269|PubMed:32150556, ECO:0000269|PubMed:32294532}.; FUNCTION: Isoform 4 does not inhibit programmed ribosomal frameshifting (-1PRF). Does not bind to ribosomes. {ECO:0000269|PubMed:30682371}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of translational frameshifting [GO:2001125]; negative regulation of viral genome replication [GO:0045071]; regulation of translational termination [GO:0006449]; response to interferon-beta [GO:0035456]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; response to type III interferon [GO:0034342]; viral translational frameshifting [GO:0075523]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]	identical protein binding [GO:0042802]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; identical protein binding [GO:0042802]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of translational frameshifting [GO:2001125]; negative regulation of viral genome replication [GO:0045071]; regulation of translational termination [GO:0006449]; response to interferon-beta [GO:0035456]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; response to type III interferon [GO:0034342]; viral translational frameshifting [GO:0075523]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26735137, ECO:0000269|PubMed:32150556}. Nucleus {ECO:0000269|PubMed:26735137}. Cytoplasm, P-body {ECO:0000269|PubMed:27974568}. Note=Predominantly found in the cytoplasm (PubMed:26735137). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568). {ECO:0000269|PubMed:26735137, ECO:0000269|PubMed:27974568}.
Q9NUL7	reviewed	DDX28_HUMAN	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28)	DDX28 MDDX28	Homo sapiens (Human)	540	FUNCTION: Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955). {ECO:0000269|PubMed:11350955, ECO:0000269|PubMed:25683708, ECO:0000269|PubMed:25683715}.		mitochondrial large ribosomal subunit assembly [GO:1902775]	cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein granule [GO:0035770]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; rRNA binding [GO:0019843]	cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein granule [GO:0035770]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; rRNA binding [GO:0019843]; mitochondrial large ribosomal subunit assembly [GO:1902775]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11350955, ECO:0000269|PubMed:25683708}. Mitochondrion {ECO:0000269|PubMed:11350955}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:25683715}. Mitochondrion matrix {ECO:0000269|PubMed:25683708}. Note=Transported between these two compartments. Nuclear localization depends on active RNA polymerase II transcription. Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269|PubMed:25683708, ECO:0000269|PubMed:25683715}.
Q9NUM3	reviewed	S39A9_HUMAN	Zinc transporter ZIP9 (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) (ZIP-9)	SLC39A9 ZIP9 UNQ714/PRO1377	Homo sapiens (Human)	307	FUNCTION: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis (PubMed:25014355, PubMed:19420709, PubMed:28219737). Participates in the zinc ions efflux out of the secretory compartments (PubMed:19420709). Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (PubMed:23505453). Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (By similarity). This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity). Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription (PubMed:34555425). Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (PubMed:25014355, PubMed:28219737). {ECO:0000250|UniProtKB:Q3KR82, ECO:0000250|UniProtKB:Q8BFU1, ECO:0000269|PubMed:19420709, ECO:0000269|PubMed:23505453, ECO:0000269|PubMed:25014355, ECO:0000269|PubMed:28219737, ECO:0000269|PubMed:34555425}.		bicellular tight junction assembly [GO:0070830]; intracellular zinc ion homeostasis [GO:0006882]; regulation of cellular response to testosterone stimulus [GO:2000654]; regulation of vascular endothelial cell proliferation [GO:1905562]; zinc ion transmembrane transport [GO:0071577]	mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	androgen binding [GO:0005497]; G protein-coupled receptor activity [GO:0004930]; zinc efflux transmembrane transporter activity [GO:0022883]; zinc ion transmembrane transporter activity [GO:0005385]	mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; androgen binding [GO:0005497]; G protein-coupled receptor activity [GO:0004930]; zinc efflux transmembrane transporter activity [GO:0022883]; zinc ion transmembrane transporter activity [GO:0005385]; bicellular tight junction assembly [GO:0070830]; intracellular zinc ion homeostasis [GO:0006882]; regulation of cellular response to testosterone stimulus [GO:2000654]; regulation of vascular endothelial cell proliferation [GO:1905562]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19420709}. Cell membrane {ECO:0000269|PubMed:25014355, ECO:0000269|PubMed:34555425}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:25014355, ECO:0000269|PubMed:34555425}. Mitochondrion {ECO:0000269|PubMed:25014355, ECO:0000269|PubMed:34555425}. Nucleus {ECO:0000269|PubMed:25014355}.
Q9NUM4	reviewed	T106B_HUMAN	Transmembrane protein 106B	TMEM106B	Homo sapiens (Human)	274	FUNCTION: In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864). Required for proper lysosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q6AYA5, ECO:0000250|UniProtKB:Q80X71, ECO:0000269|PubMed:25066864}.; FUNCTION: (Microbial infection) Plays a role in human coronavirus SARS-CoV-2 infection, but not in common cold coronaviruses HCoV-229E and HCoV-OC43 infections. Involved in ACE2-independent SARS-CoV-2 cell entry. Required for post-endocytic stage of virus entry, facilitates spike-mediated membrane fusion. Virus attachment and endocytosis can also be mediated by other cell surface receptors. {ECO:0000269|PubMed:33333024, ECO:0000269|PubMed:33686287, ECO:0000269|PubMed:37421949}.		dendrite morphogenesis [GO:0048813]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; lysosomal transport [GO:0007041]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; neuron cellular homeostasis [GO:0070050]; positive regulation of dendrite development [GO:1900006]; regulation of lysosome organization [GO:1905671]	endosome [GO:0005768]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]	ATPase binding [GO:0051117]	endosome [GO:0005768]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; ATPase binding [GO:0051117]; dendrite morphogenesis [GO:0048813]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; lysosomal transport [GO:0007041]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; neuron cellular homeostasis [GO:0070050]; positive regulation of dendrite development [GO:1900006]; regulation of lysosome organization [GO:1905671]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864}; Single-pass type II membrane protein {ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864}. Lysosome membrane {ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:25066864, ECO:0000269|PubMed:37421949}; Single-pass type II membrane protein {ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864}. Cell membrane {ECO:0000269|PubMed:37421949}; Single-pass type II membrane protein {ECO:0000255}. Note=Colocalizes with LAMP1. A small fraction resides on the cell surface (PubMed:37421949). {ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:25066864, ECO:0000269|PubMed:37421949}.
Q9NUN5	reviewed	LMBD1_HUMAN	Lysosomal cobalamin transport escort protein LMBD1 (LMBD1) (HDAg-L-interacting protein NESI) (LMBR1 domain-containing protein 1) (Nuclear export signal-interacting protein)	LMBRD1 C6orf209 NESI BM-021 CD001 MSTP044	Homo sapiens (Human)	540	FUNCTION: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors (PubMed:19136951). Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome (PubMed:27456980). Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K0B2, ECO:0000269|PubMed:19136951, ECO:0000269|PubMed:27456980, ECO:0000303|PubMed:25535791}.; FUNCTION: [Isoform 3]: (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV). {ECO:0000269|PubMed:15956556}.		clathrin-dependent endocytosis [GO:0072583]; gastrulation [GO:0007369]; insulin receptor internalization [GO:0038016]; protein localization to lysosome [GO:0061462]	clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated vesicle [GO:0030136]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	AP-2 adaptor complex binding [GO:0035612]; clathrin heavy chain binding [GO:0032050]; cobalamin binding [GO:0031419]; insulin receptor binding [GO:0005158]; protein transporter activity [GO:0140318]	clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated vesicle [GO:0030136]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; AP-2 adaptor complex binding [GO:0035612]; clathrin heavy chain binding [GO:0032050]; cobalamin binding [GO:0031419]; insulin receptor binding [GO:0005158]; protein transporter activity [GO:0140318]; clathrin-dependent endocytosis [GO:0072583]; gastrulation [GO:0007369]; insulin receptor internalization [GO:0038016]; protein localization to lysosome [GO:0061462]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27456980}. Lysosome membrane {ECO:0000269|PubMed:19136951, ECO:0000269|PubMed:27456980, ECO:0000269|PubMed:28572511, ECO:0000269|PubMed:33845046}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8K0B2}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q8K0B2}.
Q9NUN7	reviewed	ACER3_HUMAN	Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 3.5.1.-) (EC 3.5.1.23) (Alkaline dihydroceramidase SB89) (Alkaline phytoceramidase) (aPHC)	ACER3 APHC PHCA	Homo sapiens (Human)	267	FUNCTION: Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:20068046, PubMed:26792856, PubMed:20207939, PubMed:11356846, PubMed:30575723). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20068046). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (PubMed:20207939). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity). {ECO:0000250|UniProtKB:Q9D099, ECO:0000269|PubMed:11356846, ECO:0000269|PubMed:20068046, ECO:0000269|PubMed:20207939, ECO:0000269|PubMed:26792856, ECO:0000269|PubMed:30575723, ECO:0000303|PubMed:20068046}.		ceramide catabolic process [GO:0046514]; inflammatory response [GO:0006954]; myelination [GO:0042552]; phytosphingosine biosynthetic process [GO:0071602]; positive regulation of cell population proliferation [GO:0008284]; regulation of programmed cell death [GO:0043067]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; ceramidase activity [GO:0102121]; dihydroceramidase activity [GO:0071633]; N-acylsphingosine amidohydrolase activity [GO:0017040]; phytoceramidase activity [GO:0070774]; zinc ion binding [GO:0008270]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; ceramidase activity [GO:0102121]; dihydroceramidase activity [GO:0071633]; N-acylsphingosine amidohydrolase activity [GO:0017040]; phytoceramidase activity [GO:0070774]; zinc ion binding [GO:0008270]; ceramide catabolic process [GO:0046514]; inflammatory response [GO:0006954]; myelination [GO:0042552]; phytosphingosine biosynthetic process [GO:0071602]; positive regulation of cell population proliferation [GO:0008284]; regulation of programmed cell death [GO:0043067]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11356846}; Multi-pass membrane protein {ECO:0000269|PubMed:11356846, ECO:0000269|PubMed:30575723}. Golgi apparatus membrane {ECO:0000269|PubMed:11356846}; Multi-pass membrane protein {ECO:0000269|PubMed:11356846, ECO:0000269|PubMed:30575723}.
Q9NUP9	reviewed	LIN7C_HUMAN	Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)	LIN7C MALS3 VELI3	Homo sapiens (Human)	197	FUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:O88952}.		exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; morphogenesis of an epithelial sheet [GO:0002011]; neurotransmitter secretion [GO:0007269]; protein localization to basolateral plasma membrane [GO:1903361]; protein transport [GO:0015031]	basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; MPP7-DLG1-LIN7 complex [GO:0097025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; synapse [GO:0045202]	cytoskeletal protein binding [GO:0008092]; L27 domain binding [GO:0097016]; protein domain specific binding [GO:0019904]	basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; MPP7-DLG1-LIN7 complex [GO:0097025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; synapse [GO:0045202]; cytoskeletal protein binding [GO:0008092]; L27 domain binding [GO:0097016]; protein domain specific binding [GO:0019904]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; morphogenesis of an epithelial sheet [GO:0002011]; neurotransmitter secretion [GO:0007269]; protein localization to basolateral plasma membrane [GO:1903361]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Basolateral cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Cell junction {ECO:0000250}. Postsynaptic density membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Note=Mainly basolateral in renal epithelial cells. {ECO:0000250}.
Q9NUQ2	reviewed	PLCE_HUMAN	1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 5) (1-AGP acyltransferase 5) (1-AGPAT 5) (Lysophosphatidic acid acyltransferase epsilon) (LPAAT-epsilon)	AGPAT5	Homo sapiens (Human)	364	FUNCTION: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed:21173190). Activity toward lysophosphatidylglycerol not detectable (PubMed:21173190). {ECO:0000269|PubMed:21173190}.		acylglycerol metabolic process [GO:0006639]; CDP-diacylglycerol biosynthetic process [GO:0016024]; hematopoietic progenitor cell differentiation [GO:0002244]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phospholipid biosynthetic process [GO:0008654]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acyltransferase activity [GO:0016746]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acyltransferase activity [GO:0016746]; acylglycerol metabolic process [GO:0006639]; CDP-diacylglycerol biosynthetic process [GO:0016024]; hematopoietic progenitor cell differentiation [GO:0002244]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phospholipid biosynthetic process [GO:0008654]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21173190}; Multi-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:21173190}. Mitochondrion {ECO:0000269|PubMed:21173190}.
Q9NUQ3	reviewed	TXLNG_HUMAN	Gamma-taxilin (Environmental lipopolysaccharide-responding gene protein) (Factor inhibiting ATF4-mediated transcription) (FIAT) (Lipopolysaccharide-specific response protein 5)	TXLNG CXorf15 ELRG LSR5	Homo sapiens (Human)	528	FUNCTION: May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. {ECO:0000269|PubMed:15911876, ECO:0000269|PubMed:18068885}.	MISCELLANEOUS: Depletion of TXLNG by siRNA decreases the percentage of Hep-G2 cells arrested in G1 phase.	cell cycle [GO:0007049]; regulation of bone mineralization [GO:0030500]; regulation of cell cycle [GO:0051726]; regulation of cell cycle process [GO:0010564]	cytosol [GO:0005829]; nuclear membrane [GO:0031965]	DNA-binding transcription factor binding [GO:0140297]; syntaxin binding [GO:0019905]	cytosol [GO:0005829]; nuclear membrane [GO:0031965]; DNA-binding transcription factor binding [GO:0140297]; syntaxin binding [GO:0019905]; cell cycle [GO:0007049]; regulation of bone mineralization [GO:0030500]; regulation of cell cycle [GO:0051726]; regulation of cell cycle process [GO:0010564]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:15911876}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8BHN1}.
Q9NUQ7	reviewed	UFSP2_HUMAN	Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-)	UFSP2 C4orf20	Homo sapiens (Human)	469	FUNCTION: Thiol-dependent isopeptidase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins (PubMed:25219498, PubMed:32160526). Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (PubMed:25219498). Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (PubMed:25219498). {ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:33473208}.		proteolysis [GO:0006508]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	deUFMylase activity [GO:0071567]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; deUFMylase activity [GO:0071567]; proteolysis [GO:0006508]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99K23}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99K23}. Nucleus {ECO:0000250|UniProtKB:Q99K23}.
Q9NUQ9	reviewed	CYRIB_HUMAN	CYFIP-related Rac1 interactor B (L1)	CYRIB CYRI FAM49B BM-009	Homo sapiens (Human)	324	FUNCTION: Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). {ECO:0000250|UniProtKB:Q921M7, ECO:0000269|PubMed:29059164, ECO:0000269|PubMed:30250061, ECO:0000269|PubMed:31285585}.		cellular response to molecule of bacterial origin [GO:0071219]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; positive regulation of memory T cell activation [GO:2000568]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of type II interferon production [GO:0032729]; regulation of cell migration [GO:0030334]; regulation of chemotaxis [GO:0050920]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitochondrial fission [GO:0090140]	cilium [GO:0005929]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; platelet alpha granule lumen [GO:0031093]	MHC class Ib protein binding, via antigen binding groove [GO:0023030]; small GTPase binding [GO:0031267]	cilium [GO:0005929]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; platelet alpha granule lumen [GO:0031093]; MHC class Ib protein binding, via antigen binding groove [GO:0023030]; small GTPase binding [GO:0031267]; cellular response to molecule of bacterial origin [GO:0071219]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; positive regulation of memory T cell activation [GO:2000568]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of type II interferon production [GO:0032729]; regulation of cell migration [GO:0030334]; regulation of chemotaxis [GO:0050920]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitochondrial fission [GO:0090140]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:29059164}.
Q9NUS5	reviewed	AP5S1_HUMAN	AP-5 complex subunit sigma-1 (Adaptor-related protein complex 5 sigma subunit) (Sigma5)	AP5S1 C20orf29	Homo sapiens (Human)	200	FUNCTION: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20613862, ECO:0000269|PubMed:22022230}.		double-strand break repair via homologous recombination [GO:0000724]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; cytosol [GO:0005829]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]		AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; cytosol [GO:0005829]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; double-strand break repair via homologous recombination [GO:0000724]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22022230}. Late endosome membrane {ECO:0000305|PubMed:22022230}; Peripheral membrane protein {ECO:0000305|PubMed:22022230}; Cytoplasmic side {ECO:0000305|PubMed:22022230}. Lysosome membrane {ECO:0000305|PubMed:22022230}; Peripheral membrane protein {ECO:0000305|PubMed:22022230}; Cytoplasmic side {ECO:0000305|PubMed:22022230}.
Q9NUT2	reviewed	MITOS_HUMAN	Mitochondrial potassium channel ATP-binding subunit (ATP-binding cassette sub-family B member 8, mitochondrial) (ABCB8) (Mitochondrial ATP-binding cassette 1) (M-ABC1) (Mitochondrial sulfonylurea-receptor) (MITOSUR)	ABCB8 MABC1 MITOSUR	Homo sapiens (Human)	735	FUNCTION: ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane (PubMed:31435016). Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (PubMed:31435016). Plays a role in mitochondrial iron transport (PubMed:30623799). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity). {ECO:0000250|UniProtKB:Q9CXJ4, ECO:0000269|PubMed:30623799, ECO:0000269|PubMed:31435016}.		cell volume homeostasis [GO:0006884]; mitochondrial potassium ion transmembrane transport [GO:0140141]; potassium ion transmembrane transport [GO:0071805]; transmembrane transport [GO:0055085]	ATP-binding cassette (ABC) transporter complex [GO:0043190]; mitochondrial ATP-gated potassium channel complex [GO:0062157]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	ATP-binding cassette (ABC) transporter complex [GO:0043190]; mitochondrial ATP-gated potassium channel complex [GO:0062157]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cell volume homeostasis [GO:0006884]; mitochondrial potassium ion transmembrane transport [GO:0140141]; potassium ion transmembrane transport [GO:0071805]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16259955, ECO:0000269|PubMed:31435016}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Q9NUU6	reviewed	OTULL_HUMAN	Inactive ubiquitin thioesterase OTULINL	OTULINL FAM105A	Homo sapiens (Human)	356	FUNCTION: Lacks deubiquitinase activity. {ECO:0000269|PubMed:31056421}.			cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; nuclear envelope [GO:0005635]		cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; nuclear envelope [GO:0005635]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31056421}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:31056421}; Peripheral membrane protein {ECO:0000269|PubMed:31056421}. Nucleus envelope {ECO:0000269|PubMed:31056421}.
Q9NUU7	reviewed	DD19A_HUMAN	ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DDX19-like protein) (DEAD box protein 19A)	DDX19A DDX19L	Homo sapiens (Human)	478	FUNCTION: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. {ECO:0000250|UniProtKB:Q9UMR2}.		poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of apoptotic process [GO:0043065]; response to zinc ion [GO:0010043]	cytoplasmic stress granule [GO:0010494]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasmic stress granule [GO:0010494]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of apoptotic process [GO:0043065]; response to zinc ion [GO:0010043]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UMR2}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9UMR2}. Note=Associates with the nuclear pore complex cytoplasmic fibrils. {ECO:0000250|UniProtKB:Q9UMR2}.
Q9NUV7	reviewed	SPTC3_HUMAN	Serine palmitoyltransferase 3 (EC 2.3.1.50) (Long chain base biosynthesis protein 2b) (LCB2b) (Long chain base biosynthesis protein 3) (LCB 3) (Serine-palmitoyl-CoA transferase 3) (SPT 3)	SPTLC3 C20orf38 SPTLC2L	Homo sapiens (Human)	552	FUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:19648650, PubMed:19416851). The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19648650, PubMed:19416851). {ECO:0000269|PubMed:19416851, ECO:0000269|PubMed:19648650}.		ceramide biosynthetic process [GO:0046513]; sphingoid biosynthetic process [GO:0046520]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]	endoplasmic reticulum membrane [GO:0005789]; serine C-palmitoyltransferase complex [GO:0017059]	pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758]	endoplasmic reticulum membrane [GO:0005789]; serine C-palmitoyltransferase complex [GO:0017059]; pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758]; ceramide biosynthetic process [GO:0046513]; sphingoid biosynthetic process [GO:0046520]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:19416851}; Single-pass membrane protein {ECO:0000305|PubMed:19416851}.
Q9NUV9	reviewed	GIMA4_HUMAN	GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4)	GIMAP4 IAN1 IMAP4 MSTP062	Homo sapiens (Human)	329	FUNCTION: During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. {ECO:0000250, ECO:0000250|UniProtKB:Q99JY3}.			cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]	GTP binding [GO:0005525]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; GTP binding [GO:0005525]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23454188}.
Q9NUW8	reviewed	TYDP1_HUMAN	Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-)	TDP1	Homo sapiens (Human)	608	FUNCTION: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. {ECO:0000269|PubMed:12023295, ECO:0000269|PubMed:15111055, ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202, ECO:0000269|PubMed:22822062}.		DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; single strand break repair [GO:0000012]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	3'-tyrosyl-DNA phosphodiesterase activity [GO:0017005]; double-stranded DNA binding [GO:0003690]; exonuclease activity [GO:0004527]; single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; 3'-tyrosyl-DNA phosphodiesterase activity [GO:0017005]; double-stranded DNA binding [GO:0003690]; exonuclease activity [GO:0004527]; single-stranded DNA binding [GO:0003697]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; single strand break repair [GO:0000012]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15647511}. Cytoplasm {ECO:0000269|PubMed:15647511}.
Q9NUX5	reviewed	POTE1_HUMAN	Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein)	POT1	Homo sapiens (Human)	634	FUNCTION: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. {ECO:0000269|PubMed:12768206, ECO:0000269|PubMed:12781132, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:17237768, ECO:0000269|PubMed:20231318}.		DNA duplex unwinding [GO:0032508]; establishment of protein localization to telomere [GO:0070200]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA helicase activity [GO:1905776]; positive regulation of DNA strand elongation [GO:0060383]; positive regulation of helicase activity [GO:0051096]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of DNA helicase activity [GO:1905774]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of telomere maintenance via telomerase [GO:0032210]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]; telomere maintenance via telomerase [GO:0007004]; telomeric D-loop disassembly [GO:0061820]	chromosome, telomeric region [GO:0000781]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; shelterin complex [GO:0070187]	8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; DEAD/H-box RNA helicase binding [GO:0017151]; G-rich single-stranded DNA binding [GO:1990955]; G-rich strand telomeric DNA binding [GO:0098505]; single-stranded telomeric DNA binding [GO:0043047]; telomerase inhibitor activity [GO:0010521]; telomeric D-loop binding [GO:0061821]; telomeric DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; shelterin complex [GO:0070187]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; DEAD/H-box RNA helicase binding [GO:0017151]; G-rich single-stranded DNA binding [GO:1990955]; G-rich strand telomeric DNA binding [GO:0098505]; single-stranded telomeric DNA binding [GO:0043047]; telomerase inhibitor activity [GO:0010521]; telomeric D-loop binding [GO:0061821]; telomeric DNA binding [GO:0042162]; DNA duplex unwinding [GO:0032508]; establishment of protein localization to telomere [GO:0070200]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA helicase activity [GO:1905776]; positive regulation of DNA strand elongation [GO:0060383]; positive regulation of helicase activity [GO:0051096]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of DNA helicase activity [GO:1905774]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of telomere maintenance via telomerase [GO:0032210]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]; telomere maintenance via telomerase [GO:0007004]; telomeric D-loop disassembly [GO:0061820]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12391173}. Chromosome, telomere {ECO:0000269|PubMed:12391173}. Note=Colocalizes with telomeric DNA.
Q9NUY8	reviewed	TBC23_HUMAN	TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1)	TBC1D23 NS4ATP1	Homo sapiens (Human)	699	FUNCTION: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}.		brain development [GO:0007420]; embryonic brain development [GO:1990403]; neuron projection development [GO:0031175]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle tethering to Golgi [GO:0099041]; vesicle-mediated transport [GO:0016192]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802]		cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802]; brain development [GO:0007420]; embryonic brain development [GO:1990403]; neuron projection development [GO:0031175]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle tethering to Golgi [GO:0099041]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:28823706, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}. Cytoplasmic vesicle {ECO:0000269|PubMed:29426865}. Note=Localization to the trans-Golgi is regulated by ARL1 and ARL5B/ARL8. ARL1 increases Golgi localization, while ARL5B decreases it. Recruitment to the trans-Golgi network requires the presence of GOLGA1 and GOLGA4, but not that of FAM91A1 (PubMed:29084197, PubMed:28823706). Recruited on AP-1-derived vesicles by WDR11 complex (PubMed:29426865). {ECO:0000269|PubMed:28823706, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}.
Q9NV06	reviewed	DCA13_HUMAN	DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1)	DCAF13 WDSOF1 HSPC064	Homo sapiens (Human)	445	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition (PubMed:30283081). {ECO:0000269|PubMed:30283081, ECO:0000269|PubMed:34516797}.; FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that plays a key role in embryo preimplantation and is required for normal meiotic cycle progression in oocytes (PubMed:16949367, PubMed:30111536, PubMed:31492966). Acts as a maternal factor that regulates oocyte and zygotic chromatin tightness during maternal to zygotic transition (By similarity). Also involved in the transformation of the endometrium into the decidua, known as decidualization, providing a solid foundation for implantation of blastocysts (PubMed:35932979). Recognizes the histone methyltransferases SUV39H1 and SUV39H2 and directs them to polyubiquitination and proteasomal degradation, which facilitates the H3K9me3 removal and early zygotic gene expression, essential steps for progressive genome reprogramming and the establishment of pluripotency during preimplantation embryonic development (PubMed:30111536). Supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting the polyubiquitination and degradation of PTEN, a lipid phosphatase that inhibits PI3K pathway as well as oocyte growth and maturation (PubMed:31492966). Targets PMP22 for polyubiquitination and proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:Q6PAC3, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:30111536, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:35932979}.		decidualization [GO:0046697]; epigenetic programming in the zygotic pronuclei [GO:0044725]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; oocyte growth [GO:0001555]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; rRNA processing [GO:0006364]; spindle assembly involved in female meiosis [GO:0007056]	cell junction [GO:0030054]; centrosome [GO:0005813]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	nuclear estrogen receptor binding [GO:0030331]; RNA binding [GO:0003723]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	cell junction [GO:0030054]; centrosome [GO:0005813]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; nuclear estrogen receptor binding [GO:0030331]; RNA binding [GO:0003723]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; decidualization [GO:0046697]; epigenetic programming in the zygotic pronuclei [GO:0044725]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; oocyte growth [GO:0001555]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; rRNA processing [GO:0006364]; spindle assembly involved in female meiosis [GO:0007056]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:24754225, ECO:0000269|PubMed:30283081, ECO:0000269|PubMed:34516797}. Note=In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component. {ECO:0000269|PubMed:24754225}.
Q9NV12	reviewed	TM140_HUMAN	Transmembrane protein 140	TMEM140	Homo sapiens (Human)	185				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NV23	reviewed	SAST_HUMAN	S-acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Augmented in rheumatoid arthritis 1) (AURA1) (Oleoyl-ACP hydrolase) (Thioesterase 2) (TE2) (Thioesterase II) (Thioesterase domain-containing protein 1)	OLAH THEDC1	Homo sapiens (Human)	265	FUNCTION: Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16). {ECO:0000269|PubMed:26663084}.		lipid biosynthetic process [GO:0008610]; medium-chain fatty acid biosynthetic process [GO:0051792]	cytosol [GO:0005829]	dodecanoyl-[acyl-carrier-protein] hydrolase activity [GO:0047381]; myristoyl-[acyl-carrier-protein] hydrolase activity [GO:0016295]; myristoyl-CoA hydrolase activity [GO:0102991]; oleoyl-[acyl-carrier-protein] hydrolase activity [GO:0004320]; palmitoyl-[acyl-carrier-protein] hydrolase activity [GO:0016296]; palmitoyl-CoA hydrolase activity [GO:0016290]	cytosol [GO:0005829]; dodecanoyl-[acyl-carrier-protein] hydrolase activity [GO:0047381]; myristoyl-[acyl-carrier-protein] hydrolase activity [GO:0016295]; myristoyl-CoA hydrolase activity [GO:0102991]; oleoyl-[acyl-carrier-protein] hydrolase activity [GO:0004320]; palmitoyl-[acyl-carrier-protein] hydrolase activity [GO:0016296]; palmitoyl-CoA hydrolase activity [GO:0016290]; lipid biosynthetic process [GO:0008610]; medium-chain fatty acid biosynthetic process [GO:0051792]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P08635}.
Q9NV29	reviewed	TM100_HUMAN	Transmembrane protein 100	TMEM100	Homo sapiens (Human)	134	FUNCTION: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. {ECO:0000250|UniProtKB:Q9CQG9}.		angiogenesis [GO:0001525]; arterial endothelial cell differentiation [GO:0060842]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; in utero embryonic development [GO:0001701]; Notch signaling pathway [GO:0007219]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of vasculogenesis [GO:2001214]; regulation of calcium-mediated signaling [GO:0050848]; regulation of sensory perception of pain [GO:0051930]; vasculogenesis [GO:0001570]	endoplasmic reticulum [GO:0005783]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]		endoplasmic reticulum [GO:0005783]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; angiogenesis [GO:0001525]; arterial endothelial cell differentiation [GO:0060842]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; in utero embryonic development [GO:0001701]; Notch signaling pathway [GO:0007219]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of vasculogenesis [GO:2001214]; regulation of calcium-mediated signaling [GO:0050848]; regulation of sensory perception of pain [GO:0051930]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Perikaryon. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system.
Q9NV31	reviewed	IMP3_HUMAN	U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3) (BRMS2)	IMP3 C15orf12 MRPS4	Homo sapiens (Human)	184	FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}.		maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome [GO:0030684]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]; snoRNA binding [GO:0030515]; structural constituent of ribosome [GO:0003735]	Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome [GO:0030684]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; snoRNA binding [GO:0030515]; structural constituent of ribosome [GO:0003735]; maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}.
Q9NV35	reviewed	NUD15_HUMAN	Nucleotide triphosphate diphosphatase NUDT15 (EC 3.6.1.9) (MutT homolog 2) (MTH2) (Nucleoside diphosphate-linked moiety X motif 15) (Nudix motif 15) (Nucleoside diphosphate-linked to another moiety X hydrolase 15) (Nudix hydrolase 15)	NUDT15 MTH2	Homo sapiens (Human)	164	FUNCTION: May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). {ECO:0000250|UniProtKB:Q8BG93, ECO:0000269|PubMed:19419956, ECO:0000269|PubMed:22556419, ECO:0000269|PubMed:25108385, ECO:0000269|PubMed:26238318}.		dGTP catabolic process [GO:0006203]; DNA protection [GO:0042262]; mitotic cell cycle [GO:0000278]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside phosphate catabolic process [GO:1901292]; purine nucleotide catabolic process [GO:0006195]; regulation of proteasomal protein catabolic process [GO:0061136]; response to reactive oxygen species [GO:0000302]; xenobiotic catabolic process [GO:0042178]	cytosol [GO:0005829]	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity [GO:0035539]; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; 8-oxo-dGDP phosphatase activity [GO:0044715]; metal ion binding [GO:0046872]; nucleoside triphosphate diphosphatase activity [GO:0047429]	cytosol [GO:0005829]; 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity [GO:0035539]; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; 8-oxo-dGDP phosphatase activity [GO:0044715]; metal ion binding [GO:0046872]; nucleoside triphosphate diphosphatase activity [GO:0047429]; dGTP catabolic process [GO:0006203]; DNA protection [GO:0042262]; mitotic cell cycle [GO:0000278]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside phosphate catabolic process [GO:1901292]; purine nucleotide catabolic process [GO:0006195]; regulation of proteasomal protein catabolic process [GO:0061136]; response to reactive oxygen species [GO:0000302]; xenobiotic catabolic process [GO:0042178]	
Q9NV56	reviewed	MRGBP_HUMAN	MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4)	MRGBP C20orf20	Homo sapiens (Human)	204	FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.		chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357]	NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]		NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q9NV58	reviewed	RN19A_HUMAN	E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38)	RNF19A RNF19	Homo sapiens (Human)	838	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}.		microtubule cytoskeleton organization [GO:0000226]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; ubiquitin-dependent protein catabolic process [GO:0006511]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; postsynapse [GO:0098794]; ubiquitin ligase complex [GO:0000151]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; postsynapse [GO:0098794]; ubiquitin ligase complex [GO:0000151]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787}. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
Q9NV64	reviewed	TM39A_HUMAN	Transmembrane protein 39A	TMEM39A SUSR2	Homo sapiens (Human)	488	FUNCTION: Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (PubMed:31806350). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (PubMed:31806350). {ECO:0000269|PubMed:31806350}.; FUNCTION: (Microbial infection) Positively regulates the replication of encephalomyocarditis virus (EMCV) via autophagy-dependent pathway. {ECO:0000269|PubMed:31849860}.		autophagy [GO:0006914]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of autophagosome maturation [GO:1901097]; positive regulation of viral genome replication [GO:0045070]	endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]; autophagy [GO:0006914]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of autophagosome maturation [GO:1901097]; positive regulation of viral genome replication [GO:0045070]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:31806350}; Multi-pass membrane protein {ECO:0000255}.
Q9NV70	reviewed	EXOC1_HUMAN	Exocyst complex component 1 (Exocyst complex component Sec3)	EXOC1 SEC3 SEC3L1 BM-012	Homo sapiens (Human)	894	FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; FUNCTION: (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. {ECO:0000269|PubMed:19889084}.		defense response to virus [GO:0051607]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; defense response to virus [GO:0051607]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	SUBCELLULAR LOCATION: Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Cytoplasm {ECO:0000269|PubMed:16181645, ECO:0000269|PubMed:19889084}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19889084}. Cell membrane {ECO:0000269|PubMed:16181645}. Note=Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). Localizes in cell membrane in the presence of SLC6A9 (PubMed:16181645). {ECO:0000269|PubMed:16181645, ECO:0000269|PubMed:16213214}.
Q9NV79	reviewed	PCMD2_HUMAN	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2	PCMTD2 C20orf36	Homo sapiens (Human)	361	FUNCTION: May act as a substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May bind to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but probably does not display methyltransferase activity. {ECO:0000250|UniProtKB:Q96MG8}.		protein modification process [GO:0036211]	cytoplasm [GO:0005737]	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719]	cytoplasm [GO:0005737]; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P22061}.
Q9NV88	reviewed	INT9_HUMAN	Integrator complex subunit 9 (Int9) (Protein related to CPSF subunits of 74 kDa) (RC-74)	INTS9 RC74	Homo sapiens (Human)	658	FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.	MISCELLANEOUS: Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure.	negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	cytosol [GO:0005829]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15684398, ECO:0000269|PubMed:23904267}.
Q9NV92	reviewed	NFIP2_HUMAN	NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413)	NDFIP2 KIAA1165 N4WBP5A	Homo sapiens (Human)	336	FUNCTION: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q91ZP6, ECO:0000269|PubMed:12761501, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:20534535, ECO:0000269|PubMed:26363003}.		metal ion transport [GO:0030001]; negative regulation of gene expression [GO:0010629]; negative regulation of protein transport [GO:0051224]; negative regulation of transporter activity [GO:0032410]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; ubiquitin-dependent protein catabolic process [GO:0006511]; vacuolar transport [GO:0007034]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; multivesicular body membrane [GO:0032585]; perinuclear region of cytoplasm [GO:0048471]	WW domain binding [GO:0050699]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; multivesicular body membrane [GO:0032585]; perinuclear region of cytoplasm [GO:0048471]; WW domain binding [GO:0050699]; metal ion transport [GO:0030001]; negative regulation of gene expression [GO:0010629]; negative regulation of protein transport [GO:0051224]; negative regulation of transporter activity [GO:0032410]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; ubiquitin-dependent protein catabolic process [GO:0006511]; vacuolar transport [GO:0007034]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18776082}; Multi-pass membrane protein {ECO:0000269|PubMed:18776082}. Golgi apparatus membrane {ECO:0000269|PubMed:12796489, ECO:0000269|PubMed:26363003}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:26363003}.
Q9NV96	reviewed	CC50A_HUMAN	Cell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A)	TMEM30A C6orf67 CDC50A	Homo sapiens (Human)	361	FUNCTION: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. {ECO:0000269|PubMed:20510206, ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:21289302, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:29799007, ECO:0000269|PubMed:32493773}.		aminophospholipid transport [GO:0015917]; phospholipid translocation [GO:0045332]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phospholipid translocation [GO:0061092]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; protein localization to endosome [GO:0036010]; xenobiotic transmembrane transport [GO:0006855]	apical plasma membrane [GO:0016324]; azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; transport vesicle membrane [GO:0030658]	aminophospholipid flippase activity [GO:0015247]; structural molecule activity [GO:0005198]	apical plasma membrane [GO:0016324]; azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; transport vesicle membrane [GO:0030658]; aminophospholipid flippase activity [GO:0015247]; structural molecule activity [GO:0005198]; aminophospholipid transport [GO:0015917]; phospholipid translocation [GO:0045332]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phospholipid translocation [GO:0061092]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; protein localization to endosome [GO:0036010]; xenobiotic transmembrane transport [GO:0006855]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}. Apical cell membrane {ECO:0000250}.
Q9NVA1	reviewed	UQCC1_HUMAN	Ubiquinol-cytochrome c reductase complex assembly factor 1 (Basic FGF-repressed Zic-binding protein) (bFGF-repressed Zic-binding protein) (bFZb) (Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog)	UQCC1 BZFB C20orf44 UQCC	Homo sapiens (Human)	299	FUNCTION: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability. {ECO:0000269|PubMed:24385928}.	MISCELLANEOUS: [Isoform 4]: May be due to a competing donor splice site. {ECO:0000305}.	mitochondrial respiratory chain complex III assembly [GO:0034551]	cytoplasmic vesicle [GO:0031410]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		cytoplasmic vesicle [GO:0031410]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; mitochondrial respiratory chain complex III assembly [GO:0034551]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:24385928}. Cytoplasmic vesicle {ECO:0000250}. Note=Cytoplasmic vesicular structures. {ECO:0000250}.
Q9NVA2	reviewed	SEP11_HUMAN	Septin-11	SEPTIN11 SEPT11	Homo sapiens (Human)	429	FUNCTION: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:19234302, ECO:0000305}.		cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of synapse organization [GO:0050807]	axon [GO:0030424]; cell division site [GO:0032153]; dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; microtubule cytoskeleton [GO:0015630]; postsynaptic specialization of symmetric synapse [GO:0099629]; septin complex [GO:0031105]; septin ring [GO:0005940]; stress fiber [GO:0001725]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]	axon [GO:0030424]; cell division site [GO:0032153]; dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; microtubule cytoskeleton [GO:0015630]; postsynaptic specialization of symmetric synapse [GO:0099629]; septin complex [GO:0031105]; septin ring [GO:0005940]; stress fiber [GO:0001725]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]; cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of synapse organization [GO:0050807]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Synapse. Cell projection, dendritic spine. Cell projection, axon {ECO:0000250}. Note=Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
Q9NVC3	reviewed	S38A7_HUMAN	Sodium-coupled neutral amino acid transporter 7 (Solute carrier family 38 member 7)	SLC38A7 SNAT7	Homo sapiens (Human)	462	FUNCTION: Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation (PubMed:28416685, PubMed:35561222). The transport activity requires an acidic lysosomal lumen (PubMed:28416685). {ECO:0000269|PubMed:28416685, ECO:0000269|PubMed:35561222}.		amino acid transmembrane transport [GO:0003333]; asparagine transport [GO:0006867]; glutamine transport [GO:0006868]; sodium ion transport [GO:0006814]	axon [GO:0030424]; lysosomal membrane [GO:0005765]; neuronal cell body [GO:0043025]	L-asparagine transmembrane transporter activity [GO:0015182]; L-asparagine:sodium symporter activity [GO:0140901]; L-glutamine transmembrane transporter activity [GO:0015186]; L-glutamine:sodium symporter activity [GO:0140902]	axon [GO:0030424]; lysosomal membrane [GO:0005765]; neuronal cell body [GO:0043025]; L-asparagine transmembrane transporter activity [GO:0015182]; L-asparagine:sodium symporter activity [GO:0140901]; L-glutamine transmembrane transporter activity [GO:0015186]; L-glutamine:sodium symporter activity [GO:0140902]; amino acid transmembrane transport [GO:0003333]; asparagine transport [GO:0006867]; glutamine transport [GO:0006868]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28416685, ECO:0000269|PubMed:35561222}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BWH0}. Note=In neurons, located in soma. {ECO:0000250|UniProtKB:Q8BWH0}.
Q9NVC6	reviewed	MED17_HUMAN	Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80)	MED17 ARC77 CRSP6 DRIP77 DRIP80 TRAP80	Homo sapiens (Human)	651	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.	MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]; transcription initiation at RNA polymerase II promoter [GO:0006367]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ubiquitin ligase complex [GO:0000151]	nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ubiquitin ligase complex [GO:0000151]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NVD3	reviewed	SETD4_HUMAN	SET domain-containing protein 4 (EC 2.1.1.-) (EC 2.1.1.364)	SETD4 C21orf18 C21orf27	Homo sapiens (Human)	440	FUNCTION: Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response (PubMed:31308046). Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro-inflammatory cytokines IL6 and TNF-alpha (By similarity). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity). {ECO:0000250|UniProtKB:P58467, ECO:0000269|PubMed:31308046}.	MISCELLANEOUS: [Isoform B]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	chromatin remodeling [GO:0006338]; inflammatory response [GO:0006954]; methylation [GO:0032259]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell proliferation in bone marrow [GO:0071863]	cytosol [GO:0005829]; nucleus [GO:0005634]	histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; nucleus [GO:0005634]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; transcription coactivator activity [GO:0003713]; chromatin remodeling [GO:0006338]; inflammatory response [GO:0006954]; methylation [GO:0032259]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell proliferation in bone marrow [GO:0071863]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24738023}. Nucleus {ECO:0000269|PubMed:24738023}.
Q9NVD7	reviewed	PARVA_HUMAN	Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2)	PARVA MXRA2	Homo sapiens (Human)	372	FUNCTION: Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563}.		actin cytoskeleton organization [GO:0030036]; actin-mediated cell contraction [GO:0070252]; cilium assembly [GO:0060271]; establishment or maintenance of cell polarity [GO:0007163]; heterotypic cell-cell adhesion [GO:0034113]; outflow tract septum morphogenesis [GO:0003148]; protein stabilization [GO:0050821]; regulation of cell shape [GO:0008360]; smooth muscle cell chemotaxis [GO:0071670]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Z disc [GO:0030018]	actin binding [GO:0003779]; cadherin binding [GO:0045296]; protein kinase inhibitor activity [GO:0004860]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Z disc [GO:0030018]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; protein kinase inhibitor activity [GO:0004860]; actin cytoskeleton organization [GO:0030036]; actin-mediated cell contraction [GO:0070252]; cilium assembly [GO:0060271]; establishment or maintenance of cell polarity [GO:0007163]; heterotypic cell-cell adhesion [GO:0034113]; outflow tract septum morphogenesis [GO:0003148]; protein stabilization [GO:0050821]; regulation of cell shape [GO:0008360]; smooth muscle cell chemotaxis [GO:0071670]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]	SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Constituent of focal adhesions. Associates with the actin cytoskeleton.
Q9NVE7	reviewed	PANK4_HUMAN	4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4)	PANK4	Homo sapiens (Human)	773	FUNCTION: Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068). May play a role in the physiological regulation of CoA intracellular levels (Probable). {ECO:0000269|PubMed:27322068, ECO:0000305|PubMed:27322068}.		coenzyme A biosynthetic process [GO:0015937]	cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; coenzyme A biosynthetic process [GO:0015937]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q923S8}.
Q9NVF7	reviewed	FBX28_HUMAN	F-box only protein 28	FBXO28 CENP-30 KIAA0483	Homo sapiens (Human)	368	FUNCTION: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000250}.			kinetochore [GO:0000776]	identical protein binding [GO:0042802]	kinetochore [GO:0000776]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
Q9NVF9	reviewed	EKI2_HUMAN	Ethanolamine kinase 2 (EKI 2) (EC 2.7.1.82) (Ethanolamine kinase-like protein)	ETNK2 EKI2 HMFT1716	Homo sapiens (Human)	386	FUNCTION: Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity). {ECO:0000250}.		in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphorylation [GO:0016310]; placenta development [GO:0001890]; post-embryonic development [GO:0009791]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; ethanolamine kinase activity [GO:0004305]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; ethanolamine kinase activity [GO:0004305]; in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphorylation [GO:0016310]; placenta development [GO:0001890]; post-embryonic development [GO:0009791]	
Q9NVH0	reviewed	EXD2_HUMAN	Exonuclease 3'-5' domain-containing protein 2 (EC 3.1.11.1) (3'-5' exoribonuclease EXD2) (EC 3.1.13.-) (Exonuclease 3'-5' domain-like-containing protein 2)	EXD2 C14orf114 EXDL2	Homo sapiens (Human)	621	FUNCTION: Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466). {ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:26807646, ECO:0000269|PubMed:29335528, ECO:0000269|PubMed:31127291, ECO:0000269|PubMed:31255466}.		DNA double-strand break processing [GO:0000729]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; replication fork processing [GO:0031297]	cytoplasm [GO:0005737]; intermediate filament cytoskeleton [GO:0045111]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; 3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]	cytoplasm [GO:0005737]; intermediate filament cytoskeleton [GO:0045111]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; 3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; 3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; DNA double-strand break processing [GO:0000729]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; replication fork processing [GO:0031297]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:29599527, ECO:0000269|PubMed:31127291}; Single-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:31127291}. Mitochondrion matrix {ECO:0000269|PubMed:29335528}. Nucleus {ECO:0000269|PubMed:26807646}. Chromosome {ECO:0000269|PubMed:26807646, ECO:0000269|PubMed:31255466}. Note=Mainly localizes to the mitochondrial outer membrane (PubMed:29599527, PubMed:31127291). May translocate to the nucleus in response to DNA damage; however mechanism that explain nuclear localization are unknown and require experimental evidences (PubMed:26807646). Recruited to replication forks following replication stress (PubMed:31255466). {ECO:0000269|PubMed:26807646, ECO:0000269|PubMed:29599527, ECO:0000269|PubMed:31127291, ECO:0000269|PubMed:31255466}.
Q9NVH1	reviewed	DJC11_HUMAN	DnaJ homolog subfamily C member 11	DNAJC11	Homo sapiens (Human)	559	FUNCTION: [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. {ECO:0000269|PubMed:25111180, ECO:0000305}.		cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]	MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; SAM complex [GO:0001401]		MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; SAM complex [GO:0001401]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25997101}. Note=Isoforms show differential submitochondrial localization. A 57 kDa form (potentially isoform 3) shows either mitochondrial matrix or innermembrane (IM) localization, possibly anchored to the IM facing the matrix. A 35 kDa form behaved either as an inner membrane space (IMS) or an IM protein exposed to the IMS. {ECO:0000269|PubMed:25111180}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion outer membrane {ECO:0000269|PubMed:25111180}; Peripheral membrane protein {ECO:0000269|PubMed:25111180}.
Q9NVH2	reviewed	INT7_HUMAN	Integrator complex subunit 7 (Int7)	INTS7 C1orf73	Homo sapiens (Human)	962	FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Plays a role in DNA damage response (DDR) signaling during the S phase (PubMed:21659603). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.		cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; integrator complex [GO:0032039]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		chromosome [GO:0005694]; cytoplasm [GO:0005737]; integrator complex [GO:0032039]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21659603}. Chromosome {ECO:0000269|PubMed:21659603}. Cytoplasm {ECO:0000269|PubMed:23904267}. Note=Localizes to sites of DNA damage in a H2AX-independent manner.
Q9NVH6	reviewed	TMLH_HUMAN	Trimethyllysine dioxygenase, mitochondrial (EC 1.14.11.8) (Epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (Epsilon-trimethyllysine hydroxylase) (TML hydroxylase) (TML-alpha-ketoglutarate dioxygenase) (TML dioxygenase) (TMLD)	TMLHE TMLH	Homo sapiens (Human)	421	FUNCTION: Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (PubMed:11431483, PubMed:23092983). {ECO:0000269|PubMed:11431483, ECO:0000269|PubMed:23092983}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing. Lacks enzymatic activity. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing. Lacks enzymatic activity. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing. Lacks enzymatic activity. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing. Lacks enzymatic activity. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative splicing. Lacks the mitochondrial transit signal. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 8]: Produced by alternative promoter usage. Although the expression of the alternative 5' exon has been detected by PCR in heart and skeletal muscle, the identification of the alternative promoter leading to this form remains elusive (PubMed:17408883). {ECO:0000305|PubMed:17408883}.	carnitine biosynthetic process [GO:0045329]; negative regulation of oxidoreductase activity [GO:0051354]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	iron ion binding [GO:0005506]; trimethyllysine dioxygenase activity [GO:0050353]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; iron ion binding [GO:0005506]; trimethyllysine dioxygenase activity [GO:0050353]; carnitine biosynthetic process [GO:0045329]; negative regulation of oxidoreductase activity [GO:0051354]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:15754339}.
Q9NVI1	reviewed	FANCI_HUMAN	Fanconi anemia group I protein (Protein FACI)	FANCI KIAA1794	Homo sapiens (Human)	1328	FUNCTION: Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. {ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:25862789}.		cell cycle [GO:0007049]; interstrand cross-link repair [GO:0036297]; positive regulation of protein ubiquitination [GO:0031398]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]; cell cycle [GO:0007049]; interstrand cross-link repair [GO:0036297]; positive regulation of protein ubiquitination [GO:0031398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19465922}. Cytoplasm {ECO:0000269|PubMed:18445686}. Note=Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM-associated ultra-fine DNA bridges.
Q9NVI7	reviewed	ATD3A_HUMAN	ATPase family AAA domain-containing protein 3A	ATAD3A	Homo sapiens (Human)	634	FUNCTION: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). {ECO:0000269|PubMed:17210950, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:22453275, ECO:0000269|PubMed:31522117}.	MISCELLANEOUS: [Isoform 2]: May be the predominant ATAD3A form. {ECO:0000305}.	antiviral innate immune response [GO:0140374]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; regulation of cell growth [GO:0001558]	mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]	mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; antiviral innate immune response [GO:0140374]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; regulation of cell growth [GO:0001558]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:20332122, ECO:0000269|PubMed:20349121}; Single-pass membrane protein {ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:20349121}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:17210950, ECO:0000269|PubMed:18063578}. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane (PubMed:20349121, PubMed:20154147). The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids (PubMed:18063578). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:20349121}.
Q9NVJ2	reviewed	ARL8B_HUMAN	ADP-ribosylation factor-like protein 8B (EC 3.6.5.2) (ADP-ribosylation factor-like protein 10C) (Novel small G protein indispensable for equal chromosome segregation 1)	ARL8B ARL10C GIE1	Homo sapiens (Human)	186	FUNCTION: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states (PubMed:15331635, PubMed:16537643). In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion (PubMed:16650381, PubMed:16537643, PubMed:28325809, PubMed:25898167, PubMed:27808481). Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis (PubMed:22172677, PubMed:29592961, PubMed:24088571). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense (PubMed:21802320). Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes (PubMed:16537643, PubMed:25908847). Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (PubMed:25908847, PubMed:21802320). Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity). May play a role in chromosome segregation (PubMed:15331635). {ECO:0000250|UniProtKB:Q9CQW2, ECO:0000269|PubMed:15331635, ECO:0000269|PubMed:16537643, ECO:0000269|PubMed:16650381, ECO:0000269|PubMed:21802320, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:25908847, ECO:0000269|PubMed:27808481, ECO:0000269|PubMed:28325809, ECO:0000269|PubMed:29592961}.; FUNCTION: (Microbial infection) During Mycobacterium tuberculosis (Mtb) infection, is required for plasma membrane repair by controlling the exocytosis of lysosomes in macrophages. ARL8B secretion pathway is crucial to control the type of cell death of the M. tuberculosis-infected macrophages, distinguishing avirulent from virulent Mtb induced necrotic cell death. {ECO:0000269|PubMed:29592961}.; FUNCTION: (Microbial infection) During infection, coronaviruses such as SARS-CoV-2 and the chaperone HSPA5/GRP78 are probably co-released through ARL8B-dependent lysosomal exocytic pathway for unconventional egress. {ECO:0000269|PubMed:33157038}.		anterograde axonal transport [GO:0008089]; antigen processing and presentation following phagocytosis [GO:0002747]; antigen processing and presentation of polysaccharide antigen via MHC class II [GO:0002505]; autophagosome-lysosome fusion [GO:0061909]; calcium ion regulated lysosome exocytosis [GO:1990927]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; endosomal transport [GO:0016197]; endosome to lysosome transport of low-density lipoprotein particle [GO:0090117]; late endosome to lysosome transport [GO:1902774]; lysosome localization [GO:0032418]; natural killer cell mediated cytotoxicity [GO:0042267]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; viral exocytosis [GO:0046754]	axon cytoplasm [GO:1904115]; cytolytic granule membrane [GO:0101004]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; midbody [GO:0030496]; spindle midzone [GO:0051233]; synapse [GO:0045202]	alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	axon cytoplasm [GO:1904115]; cytolytic granule membrane [GO:0101004]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; midbody [GO:0030496]; spindle midzone [GO:0051233]; synapse [GO:0045202]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; anterograde axonal transport [GO:0008089]; antigen processing and presentation following phagocytosis [GO:0002747]; antigen processing and presentation of polysaccharide antigen via MHC class II [GO:0002505]; autophagosome-lysosome fusion [GO:0061909]; calcium ion regulated lysosome exocytosis [GO:1990927]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; endosomal transport [GO:0016197]; endosome to lysosome transport of low-density lipoprotein particle [GO:0090117]; late endosome to lysosome transport [GO:1902774]; lysosome localization [GO:0032418]; natural killer cell mediated cytotoxicity [GO:0042267]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; viral exocytosis [GO:0046754]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:16537643}. Lysosome membrane {ECO:0000269|PubMed:16650381, ECO:0000269|PubMed:21802320, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:27808481, ECO:0000269|PubMed:28325809, ECO:0000269|PubMed:29592961}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15331635}. Cell projection, axon {ECO:0000250|UniProtKB:Q9CQW2}. Synapse {ECO:0000250|UniProtKB:Q9CQW2}. Cytolytic granule membrane {ECO:0000269|PubMed:24088571}. Note=GTP-bound form resides on lysosomal membranes, whereas GDP-bound form is likely associated with microtubular structures (PubMed:16650381). Localizes with microtubules at the spindle mid-zone during mitosis. In dendritic cells, localizes to MHC II+ compartments (By similarity). {ECO:0000250|UniProtKB:Q9CQW2, ECO:0000269|PubMed:15331635, ECO:0000269|PubMed:16650381}.
Q9NVL1	reviewed	F86C1_HUMAN	Putative protein FAM86C1P (EC 2.1.1.-) (Protein FAM86C)	FAM86C1P FAM86C FAM86C1	Homo sapiens (Human)	165			methylation [GO:0032259]	protein-containing complex [GO:0032991]	methyltransferase activity [GO:0008168]	protein-containing complex [GO:0032991]; methyltransferase activity [GO:0008168]; methylation [GO:0032259]	
Q9NVL8	reviewed	FAME_HUMAN	Factor associated with metabolism and energy (Protein CCDC198)	CCDC198 C14orf105 FAME	Homo sapiens (Human)	296	FUNCTION: May be involved in tuning the metabolism, energy expenditure, and excretion processes. {ECO:0000250|UniProtKB:Q9CPZ1}.		energy homeostasis [GO:0097009]	cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]		cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; energy homeostasis [GO:0097009]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37248239}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9CPZ1}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9CPZ1}. Note=The localization of CCDC198 changes from membranous to vesicle-forming structures in the malignant tissue. {ECO:0000269|PubMed:37248239}.
Q9NVM4	reviewed	ANM7_HUMAN	Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7)	PRMT7 KIAA1933	Homo sapiens (Human)	692	FUNCTION: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. {ECO:0000269|PubMed:15044439, ECO:0000269|PubMed:15494416, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19110445}.	MISCELLANEOUS: May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT).	genomic imprinting [GO:0071514]; peptidyl-arginine methylation [GO:0018216]; regulation of protein binding [GO:0043393]; spliceosomal snRNP assembly [GO:0000387]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone binding [GO:0042393]; histone H4 methyltransferase activity [GO:0140939]; histone H4R3 methyltransferase activity [GO:0044020]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243]; ribonucleoprotein complex binding [GO:0043021]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone binding [GO:0042393]; histone H4 methyltransferase activity [GO:0140939]; histone H4R3 methyltransferase activity [GO:0044020]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243]; ribonucleoprotein complex binding [GO:0043021]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; genomic imprinting [GO:0071514]; peptidyl-arginine methylation [GO:0018216]; regulation of protein binding [GO:0043393]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15494416}. Nucleus {ECO:0000269|PubMed:15494416}.
Q9NVM9	reviewed	INT13_HUMAN	Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Protein asunder homolog) (Sarcoma antigen NY-SAR-95)	INTS13 ASUN C12orf11 GCT1	Homo sapiens (Human)	706	FUNCTION: Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267). {ECO:0000269|PubMed:15737938, ECO:0000269|PubMed:23097494, ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:23097494, ECO:0000305|PubMed:23904267}.	MISCELLANEOUS: RNAi in HeLa cells results in a multinucleated phenotype.	cell division [GO:0051301]; centrosome localization [GO:0051642]; flagellated sperm motility [GO:0030317]; mitotic spindle organization [GO:0007052]; protein localization to nuclear envelope [GO:0090435]; regulation of fertilization [GO:0080154]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180]	cytoplasm [GO:0005737]; integrator complex [GO:0032039]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; integrator complex [GO:0032039]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell division [GO:0051301]; centrosome localization [GO:0051642]; flagellated sperm motility [GO:0030317]; mitotic spindle organization [GO:0007052]; protein localization to nuclear envelope [GO:0090435]; regulation of fertilization [GO:0080154]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23904267}. Cytoplasm {ECO:0000269|PubMed:23097494, ECO:0000269|PubMed:23904267}. Note=Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M. {ECO:0000269|PubMed:17974005}.
Q9NVN3	reviewed	RIC8B_HUMAN	Synembryn-B (Brain synembryn) (hSyn) (Protein Ric-8B)	RIC8B	Homo sapiens (Human)	520	FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction. {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:12652642}. Note=Localizes to the cell cortex.
Q9NVN8	reviewed	GNL3L_HUMAN	Guanine nucleotide-binding protein-like 3-like protein	GNL3L	Homo sapiens (Human)	582	FUNCTION: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}.		negative regulation of protein binding [GO:0032091]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of protein stability [GO:0031647]; ribosome biogenesis [GO:0042254]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; telomerase holoenzyme complex [GO:0005697]	GTP binding [GO:0005525]; RNA binding [GO:0003723]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; telomerase holoenzyme complex [GO:0005697]; GTP binding [GO:0005525]; RNA binding [GO:0003723]; negative regulation of protein binding [GO:0032091]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of protein stability [GO:0031647]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:17034816}.
Q9NVP1	reviewed	DDX18_HUMAN	ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb)	DDX18 cPERP-D	Homo sapiens (Human)	670	FUNCTION: Probable RNA-dependent helicase.		maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]	chromosome [GO:0005694]; membrane [GO:0016020]; nucleolus [GO:0005730]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	chromosome [GO:0005694]; membrane [GO:0016020]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16963496}. Chromosome {ECO:0000269|PubMed:20813266}.
Q9NVP2	reviewed	ASF1B_HUMAN	Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II)	ASF1B	Homo sapiens (Human)	202	FUNCTION: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524, PubMed:26527279). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:20953179, PubMed:21454524, PubMed:26527279). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Required for gonad development (PubMed:12842904). {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:26527279}.		blastocyst hatching [GO:0001835]; cell differentiation [GO:0030154]; DNA replication-dependent chromatin assembly [GO:0006335]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	histone binding [GO:0042393]; histone chaperone activity [GO:0140713]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; blastocyst hatching [GO:0001835]; cell differentiation [GO:0030154]; DNA replication-dependent chromatin assembly [GO:0006335]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12842904}. Cytoplasm, cytosol {ECO:0000269|PubMed:22407294}.
Q9NVR5	reviewed	KTU_HUMAN	Protein kintoun (Dynein assembly factor 2, axonemal)	DNAAF2 C14orf104 KTU	Homo sapiens (Human)	837	FUNCTION: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. {ECO:0000255|HAMAP-Rule:MF_03069}.	MISCELLANEOUS: [Isoform 2]: May be due to exon skipping. {ECO:0000305}.	axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of left/right asymmetry [GO:0061966]; establishment of localization in cell [GO:0051649]; in utero embryonic development [GO:0001701]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158]; protein stabilization [GO:0050821]; response to retinoic acid [GO:0032526]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; protein folding chaperone complex [GO:0101031]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; protein folding chaperone complex [GO:0101031]; axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of left/right asymmetry [GO:0061966]; establishment of localization in cell [GO:0051649]; in utero embryonic development [GO:0001701]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158]; protein stabilization [GO:0050821]; response to retinoic acid [GO:0032526]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03069, ECO:0000269|PubMed:19052621}. Dynein axonemal particle {ECO:0000250|UniProtKB:B1H1W9}. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia. {ECO:0000255|HAMAP-Rule:MF_03069}.
Q9NVS9	reviewed	PNPO_HUMAN	Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase)	PNPO	Homo sapiens (Human)	261	FUNCTION: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). {ECO:0000269|PubMed:12824491, ECO:0000269|PubMed:15182361, ECO:0000269|PubMed:15772097}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxamine metabolic process [GO:0042818]; pyridoxine biosynthetic process [GO:0008615]	cytosol [GO:0005829]	FMN binding [GO:0010181]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; pyridoxamine phosphate oxidase activity [GO:0004733]	cytosol [GO:0005829]; FMN binding [GO:0010181]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; pyridoxamine phosphate oxidase activity [GO:0004733]; pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxamine metabolic process [GO:0042818]; pyridoxine biosynthetic process [GO:0008615]	
Q9NVT9	reviewed	ARMC1_HUMAN	Armadillo repeat-containing protein 1	ARMC1 ARCP	Homo sapiens (Human)	282	FUNCTION: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. {ECO:0000269|PubMed:31644573}.		intracellular distribution of mitochondria [GO:0048312]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	metal ion binding [GO:0046872]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; intracellular distribution of mitochondria [GO:0048312]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31644573}. Mitochondrion {ECO:0000269|PubMed:31644573}. Mitochondrion outer membrane {ECO:0000269|PubMed:31644573}. Note=Associates with the outer mitochondrion membrane, most likely through its C-terminus (PubMed:31644573). Not integrated into the mitochondrial outer membrane (PubMed:31644573). {ECO:0000269|PubMed:31644573}.
Q9NVU0	reviewed	RPC5_HUMAN	DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide)	POLR3E KIAA1452	Homo sapiens (Human)	708	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370}.	MISCELLANEOUS: [Isoform 3]: May result from the retention of an intron in the cDNA. {ECO:0000305}.	defense response to virus [GO:0051607]; innate immune response [GO:0045087]; tRNA transcription by RNA polymerase III [GO:0042797]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; tRNA transcription by RNA polymerase III [GO:0042797]	SUBCELLULAR LOCATION: Nucleus.
Q9NVU7	reviewed	SDA1_HUMAN	Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA)	SDAD1 NUC130	Homo sapiens (Human)	687	FUNCTION: Required for 60S pre-ribosomal subunits export to the cytoplasm. {ECO:0000250}.	MISCELLANEOUS: DAZL and PUM2 bind its 3'-UTR mRNA, suggesting that these proteins may regulate its translation.	protein transport [GO:0015031]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein transport [GO:0015031]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:14976432}.
Q9NVV0	reviewed	TM38B_HUMAN	Trimeric intracellular cation channel type B (TRIC-B) (TRICB) (Transmembrane protein 38B)	TMEM38B C9orf87	Homo sapiens (Human)	291	FUNCTION: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. {ECO:0000250|UniProtKB:Q9DAV9}.		bone development [GO:0060348]; bone mineralization [GO:0030282]; cellular response to caffeine [GO:0071313]; endoplasmic reticulum organization [GO:0007029]; establishment of localization in cell [GO:0051649]; extracellular matrix constituent secretion [GO:0070278]; lung alveolus development [GO:0048286]; lung epithelial cell differentiation [GO:0060487]; phospholipid biosynthetic process [GO:0008654]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; secretion by lung epithelial cell involved in lung growth [GO:0061033]	nuclear membrane [GO:0031965]; nucleus [GO:0005634]; sarcoplasmic reticulum membrane [GO:0033017]	identical protein binding [GO:0042802]; potassium channel activity [GO:0005267]	nuclear membrane [GO:0031965]; nucleus [GO:0005634]; sarcoplasmic reticulum membrane [GO:0033017]; identical protein binding [GO:0042802]; potassium channel activity [GO:0005267]; bone development [GO:0060348]; bone mineralization [GO:0030282]; cellular response to caffeine [GO:0071313]; endoplasmic reticulum organization [GO:0007029]; establishment of localization in cell [GO:0051649]; extracellular matrix constituent secretion [GO:0070278]; lung alveolus development [GO:0048286]; lung epithelial cell differentiation [GO:0060487]; phospholipid biosynthetic process [GO:0008654]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; secretion by lung epithelial cell involved in lung growth [GO:0061033]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9DAV9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9DAV9}.
Q9NVV4	reviewed	PAPD1_HUMAN	Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP)	MTPAP PAPD1	Homo sapiens (Human)	582	FUNCTION: Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. {ECO:0000269|PubMed:15547249, ECO:0000269|PubMed:15769737, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20970105, ECO:0000269|PubMed:21292163}.		histone mRNA catabolic process [GO:0071044]; mRNA polyadenylation [GO:0006378]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; poly(A) RNA polymerase activity [GO:1990817]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; UTP binding [GO:0002134]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; poly(A) RNA polymerase activity [GO:1990817]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; UTP binding [GO:0002134]; histone mRNA catabolic process [GO:0071044]; mRNA polyadenylation [GO:0006378]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18172165}. Mitochondrion {ECO:0000269|PubMed:15547249, ECO:0000269|PubMed:15769737}.
Q9NVV5	reviewed	AIG1_HUMAN	Androgen-induced gene 1 protein (AIG-1) (Fatty acid esters of hydroxy fatty acids hydrolase AIG1) (FAHFA hydrolase AIG1) (EC 3.1.-.-)	AIG1 CGI-103	Homo sapiens (Human)	238	FUNCTION: Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). {ECO:0000269|PubMed:27018888}.		long-chain fatty acid catabolic process [GO:0042758]	endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886]	hydrolase activity [GO:0016787]	endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886]; hydrolase activity [GO:0016787]; long-chain fatty acid catabolic process [GO:0042758]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27018888}; Multi-pass membrane protein {ECO:0000255}.
Q9NVV9	reviewed	THAP1_HUMAN	THAP domain-containing protein 1	THAP1	Homo sapiens (Human)	213	FUNCTION: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. {ECO:0000269|PubMed:12717420, ECO:0000269|PubMed:17003378, ECO:0000269|PubMed:20200153}.		cell cycle [GO:0007049]; DNA-templated transcription [GO:0006351]; endothelial cell proliferation [GO:0001935]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; DNA-templated transcription [GO:0006351]; endothelial cell proliferation [GO:0001935]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:12717420}. Nucleus, PML body {ECO:0000269|PubMed:12717420}.
Q9NVW2	reviewed	RNF12_HUMAN	E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43)	RLIM RNF12	Homo sapiens (Human)	624	FUNCTION: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}.	MISCELLANEOUS: Acts as a positive coregulator of ESR1-mediated transcription in breast cancer cells.	negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; random inactivation of X chromosome [GO:0060816]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; random inactivation of X chromosome [GO:0060816]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19117995, ECO:0000269|PubMed:19164295}.
Q9NVX0	reviewed	HAUS2_HUMAN	HAUS augmin-like complex subunit 2 (Centrosomal protein of 27 kDa) (Cep27)	HAUS2 C15orf25 CEP27	Homo sapiens (Human)	235	FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.		cell division [GO:0051301]; centrosome cycle [GO:0007098]; microtubule nucleation [GO:0007020]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]		centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; microtubule nucleation [GO:0007020]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}.
Q9NVX2	reviewed	NLE1_HUMAN	Notchless protein homolog 1	NLE1 HUSSY-07	Homo sapiens (Human)	485	FUNCTION: Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity). {ECO:0000250}.		hematopoietic stem cell homeostasis [GO:0061484]; inner cell mass cell differentiation [GO:0001826]; kidney development [GO:0001822]; mitotic cell cycle [GO:0000278]; negative regulation of mitotic cell cycle [GO:0045930]; Notch signaling pathway [GO:0007219]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; ribosomal large subunit assembly [GO:0000027]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; hematopoietic stem cell homeostasis [GO:0061484]; inner cell mass cell differentiation [GO:0001826]; kidney development [GO:0001822]; mitotic cell cycle [GO:0000278]; negative regulation of mitotic cell cycle [GO:0045930]; Notch signaling pathway [GO:0007219]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; ribosomal large subunit assembly [GO:0000027]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|Ref.5}.
Q9NW08	reviewed	RPC2_HUMAN	DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B)	POLR3B	Homo sapiens (Human)	1133	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. {ECO:0000250, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; transcription by RNA polymerase III [GO:0006383]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33417887}.
Q9NW13	reviewed	RBM28_HUMAN	RNA-binding protein 28 (RNA-binding motif protein 28)	RBM28	Homo sapiens (Human)	759	FUNCTION: Nucleolar component of the spliceosomal ribonucleoprotein complexes. {ECO:0000269|PubMed:17081119}.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	nucleolus [GO:0005730]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:17081119, ECO:0000269|Ref.7}.
Q9NW15	reviewed	ANO10_HUMAN	Anoctamin-10 (Transmembrane protein 16K)	ANO10 TMEM16K	Homo sapiens (Human)	660	FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}.	MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.	chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22075693, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22075693, ECO:0000269|PubMed:22946059}. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Q9NW38	reviewed	FANCL_HUMAN	E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia group L protein) (Fanconi anemia-associated polypeptide of 43 kDa) (FAAP43) (RING-type E3 ubiquitin transferase FANCL)	FANCL PHF9	Homo sapiens (Human)	375	FUNCTION: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784). May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. {ECO:0000269|PubMed:12973351, ECO:0000269|PubMed:16916645, ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:24389026}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; gamete generation [GO:0007276]; interstrand cross-link repair [GO:0036297]; protein monoubiquitination [GO:0006513]; regulation of cell population proliferation [GO:0042127]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; Fanconi anaemia nuclear complex [GO:0043240]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; Fanconi anaemia nuclear complex [GO:0043240]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; gamete generation [GO:0007276]; interstrand cross-link repair [GO:0036297]; protein monoubiquitination [GO:0006513]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9CR14}. Nucleus {ECO:0000250|UniProtKB:Q9CR14}.
Q9NW64	reviewed	RBM22_HUMAN	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16)	RBM22 ZC3H16 199G4	Homo sapiens (Human)	420	FUNCTION: Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30705154). Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:22246180, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154}.		cellular response to xenobiotic stimulus [GO:0071466]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of RNA splicing [GO:0033120]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	calcium-dependent protein binding [GO:0048306]; metal ion binding [GO:0046872]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; calcium-dependent protein binding [GO:0048306]; metal ion binding [GO:0046872]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070]; cellular response to xenobiotic stimulus [GO:0071466]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of RNA splicing [GO:0033120]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154}. Cytoplasm {ECO:0000269|PubMed:21122810}. Note=Nearly exclusively nuclear. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol. {ECO:0000269|PubMed:21122810}.
Q9NW75	reviewed	GPTC2_HUMAN	G patch domain-containing protein 2	GPATCH2 GPATC2	Homo sapiens (Human)	528	FUNCTION: Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}.			nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]	nucleic acid binding [GO:0003676]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; nucleic acid binding [GO:0003676]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:19432882}. Nucleus, nucleolus {ECO:0000269|PubMed:19432882}.
Q9NW81	reviewed	DMAC2_HUMAN	Distal membrane-arm assembly complex protein 2 (ATP synthase subunit s-like protein)	DMAC2 ATP5SL	Homo sapiens (Human)	257	FUNCTION: Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. {ECO:0000269|PubMed:27626371}.		mitochondrial respiratory chain complex I assembly [GO:0032981]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	mitochondrion [GO:0005739]; SCF ubiquitin ligase complex [GO:0019005]		mitochondrion [GO:0005739]; SCF ubiquitin ligase complex [GO:0019005]; mitochondrial respiratory chain complex I assembly [GO:0032981]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9D7K5}.
Q9NW97	reviewed	TMM51_HUMAN	Transmembrane protein 51	TMEM51 C1orf72	Homo sapiens (Human)	253				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NWB1	reviewed	RFOX1_HUMAN	RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) (Hexaribonucleotide-binding protein 1)	RBFOX1 A2BP A2BP1 FOX1 HRNBP1	Homo sapiens (Human)	397	FUNCTION: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. {ECO:0000269|PubMed:16537540}.		mRNA processing [GO:0006397]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of skeletal muscle cell differentiation [GO:2001014]; RNA splicing [GO:0008380]; RNA transport [GO:0050658]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nuclear stress granule [GO:0097165]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]	mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nuclear stress granule [GO:0097165]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of skeletal muscle cell differentiation [GO:2001014]; RNA splicing [GO:0008380]; RNA transport [GO:0050658]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q9NWB7	reviewed	IFT57_HUMAN	Intraflagellar transport protein 57 homolog (Dermal papilla-derived protein 8) (Estrogen-related receptor beta-like protein 1) (HIP1-interacting protein) (MHS4R2)	IFT57 DERP8 ESRRBL1 HIPPI	Homo sapiens (Human)	429	FUNCTION: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. {ECO:0000250, ECO:0000269|PubMed:11788820, ECO:0000269|PubMed:17107665, ECO:0000269|PubMed:17623017}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cilium assembly [GO:0060271]; heart looping [GO:0001947]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; keratinocyte proliferation [GO:0043616]; motile cilium assembly [GO:0044458]; negative regulation of keratinocyte proliferation [GO:0010839]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; regulation of apoptotic process [GO:0042981]; smoothened signaling pathway [GO:0007224]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; dendrite terminus [GO:0044292]; Golgi apparatus [GO:0005794]; intraciliary transport particle B [GO:0030992]; photoreceptor connecting cilium [GO:0032391]	DNA binding [GO:0003677]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; dendrite terminus [GO:0044292]; Golgi apparatus [GO:0005794]; intraciliary transport particle B [GO:0030992]; photoreceptor connecting cilium [GO:0032391]; DNA binding [GO:0003677]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cilium assembly [GO:0060271]; heart looping [GO:0001947]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; keratinocyte proliferation [GO:0043616]; motile cilium assembly [GO:0044458]; negative regulation of keratinocyte proliferation [GO:0010839]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; regulation of apoptotic process [GO:0042981]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q8BXG3}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q5EA95}. Note=Concentrates within the inner segment of cilia. {ECO:0000250}.
Q9NWD8	reviewed	TM248_HUMAN	Transmembrane protein 248	TMEM248 C7orf42	Homo sapiens (Human)	314				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NWD9	reviewed	BEX4_HUMAN	Protein BEX4 (BEX1-like protein 1) (Brain-expressed X-linked protein 4) (Nerve growth factor receptor-associated protein 3)	BEX4 BEXL1 NADE3	Homo sapiens (Human)	120	FUNCTION: May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability (PubMed:27512957). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). {ECO:0000250|UniProtKB:Q9CWT2, ECO:0000269|PubMed:27512957}.		chromosome segregation [GO:0007059]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of tubulin deacetylation [GO:1904428]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	alpha-tubulin binding [GO:0043014]; histone deacetylase binding [GO:0042826]; molecular function inhibitor activity [GO:0140678]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; alpha-tubulin binding [GO:0043014]; histone deacetylase binding [GO:0042826]; molecular function inhibitor activity [GO:0140678]; chromosome segregation [GO:0007059]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of tubulin deacetylation [GO:1904428]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:27512957}. Nucleus {ECO:0000269|PubMed:27512957}. Cytoplasm {ECO:0000269|PubMed:27512957}. Note=Also localizes to microtubules. {ECO:0000269|PubMed:27512957}.
Q9NWF4	reviewed	S52A1_HUMAN	Solute carrier family 52, riboflavin transporter, member 1 (Porcine endogenous retrovirus A receptor 2) (PERV-A receptor 2) (huPAR-2) (Protein GPR172B) (Riboflavin transporter 1) (hRFT1)	SLC52A1 GPR172B PAR2 RFT1	Homo sapiens (Human)	448	FUNCTION: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:18632736, PubMed:20463145). Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145). {ECO:0000269|PubMed:18632736, ECO:0000269|PubMed:20463145, ECO:0000303|PubMed:20463145}.; FUNCTION: (Microbial infection) May function as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). {ECO:0000305|PubMed:12740431}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	riboflavin metabolic process [GO:0006771]; riboflavin transport [GO:0032218]	plasma membrane [GO:0005886]	riboflavin transmembrane transporter activity [GO:0032217]; virus receptor activity [GO:0001618]	plasma membrane [GO:0005886]; riboflavin transmembrane transporter activity [GO:0032217]; virus receptor activity [GO:0001618]; riboflavin metabolic process [GO:0006771]; riboflavin transport [GO:0032218]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12740431, ECO:0000269|PubMed:18632736, ECO:0000269|PubMed:20463145}; Multi-pass membrane protein {ECO:0000255}.
Q9NWF9	reviewed	RN216_HUMAN	E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B)	RNF216 TRIAD3 UBCE7IP1 ZIN	Homo sapiens (Human)	866	FUNCTION: [Isoform 1]: E3 ubiquitin ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their ubiquitination (PubMed:34998453). Plays a role in the regulation of antiviral responses by promoting the degradation of TRAF3, TLR4 and TLR9 (PubMed:15107846, PubMed:19893624). In turn, down-regulates NF-kappa-B and IRF3 activation as well as beta interferon production. Participates also in the regulation of autophagy by ubiquitinating BECN1 leading to its degradation and autophagy inhibition (PubMed:25484083). Plays a role in ARC-dependent synaptic plasticity by mediating ARC ubiquitination resulting in its rapid proteasomal degradation (PubMed:24945773). Plays aso an essential role in spermatogenesis and male fertility (By similarity). Mechanistically, regulates meiosis by promoting the degradation of PRKACB through the ubiquitin-mediated lysosome pathway (By similarity). Modulates the gonadotropin-releasing hormone signal pathway by affecting the stability of STAU2 that is required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite (By similarity). {ECO:0000250|UniProtKB:P58283, ECO:0000269|PubMed:15107846, ECO:0000269|PubMed:19893624, ECO:0000269|PubMed:24945773, ECO:0000269|PubMed:25484083, ECO:0000269|PubMed:34998453}.; FUNCTION: [Isoform 3]: Inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. {ECO:0000269|PubMed:11854271}.	MISCELLANEOUS: [Isoform 3]: 4 different alternatively spliced mRNAs code for this protein isoform. {ECO:0000305}.	apoptotic process [GO:0006915]; negative regulation of type I interferon production [GO:0032480]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of defense response to virus by host [GO:0050691]; regulation of interferon-beta production [GO:0032648]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; negative regulation of type I interferon production [GO:0032480]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of defense response to virus by host [GO:0050691]; regulation of interferon-beta production [GO:0032648]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:24945773}.
Q9NWH2	reviewed	TM242_HUMAN	Transmembrane protein 242	TMEM242 C6orf35 BM-033 HSPC287	Homo sapiens (Human)	141	FUNCTION: Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3 (PubMed:33753518). Participates in the incorporation of the c-ring into vestigial complexes (PubMed:33753518). Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase (PubMed:33753518). {ECO:0000269|PubMed:33753518}.		mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]	mitochondrial inner membrane [GO:0005743]		mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:33753518}; Multi-pass membrane protein {ECO:0000269|PubMed:33753518}.
Q9NWH9	reviewed	SLTM_HUMAN	SAFB-like transcription modulator (Modulator of estrogen-induced transcription)	SLTM MET	Homo sapiens (Human)	1034	FUNCTION: When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}.		apoptotic process [GO:0006915]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; apoptotic process [GO:0006915]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Detected in punctate structures. {ECO:0000250}.
Q9NWK9	reviewed	BCD1_HUMAN	Box C/D snoRNA protein 1 (Serologically defined breast cancer antigen NY-BR-75) (Zinc finger HIT domain-containing protein 6)	ZNHIT6 BCD1 C1orf181	Homo sapiens (Human)	470	FUNCTION: Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. {ECO:0000269|PubMed:17636026}.		box C/D snoRNP assembly [GO:0000492]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; protein complex oligomerization [GO:0051259]; snoRNA localization [GO:0048254]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]	ATPase binding [GO:0051117]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; TFIID-class transcription factor complex binding [GO:0001094]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]; ATPase binding [GO:0051117]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; TFIID-class transcription factor complex binding [GO:0001094]; box C/D snoRNP assembly [GO:0000492]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; protein complex oligomerization [GO:0051259]; snoRNA localization [GO:0048254]	
Q9NWM0	reviewed	SMOX_HUMAN	Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1)	SMOX C20orf16 SMO UNQ3039/PRO9854	Homo sapiens (Human)	555	FUNCTION: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.	MISCELLANEOUS: [Isoform 1]: Low affinity for acetylated polyamine.; MISCELLANEOUS: [Isoform 2]: Low affinity for acetylated polyamine. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Major isoform. Has the highest affinity for the 3 substrates. Has a greater affinity for spermidine and spermine than for N(1)-acetylspermine. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Has the lowest Km values for the different substrates and has the highest affinity for spermidine. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Does not seem to display oxidase activity towards spermidine or N(1)-acetyl-spermine, but this has to be confirmed. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Substrate specificities and affinities comparable to those of isoform 1. {ECO:0000305}.	polyamine biosynthetic process [GO:0006596]; polyamine catabolic process [GO:0006598]; spermine catabolic process [GO:0046208]; xenobiotic metabolic process [GO:0006805]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity [GO:0052895]; norspermine:oxygen oxidoreductase activity [GO:0052894]; polyamine oxidase activity [GO:0046592]; spermine:oxygen oxidoreductase (spermidine-forming) activity [GO:0052901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity [GO:0052895]; norspermine:oxygen oxidoreductase activity [GO:0052894]; polyamine oxidase activity [GO:0046592]; spermine:oxygen oxidoreductase (spermidine-forming) activity [GO:0052901]; polyamine biosynthetic process [GO:0006596]; polyamine catabolic process [GO:0006598]; spermine catabolic process [GO:0046208]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm. Nucleus.
Q9NWM8	reviewed	FKB14_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (22 kDa FK506-binding protein) (22 kDa FKBP) (FKBP-22) (FK506-binding protein 14) (FKBP-14) (Rotamase)	FKBP14 FKBP22 UNQ322/PRO381	Homo sapiens (Human)	211	FUNCTION: PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens. {ECO:0000269|PubMed:24821723}.			endoplasmic reticulum lumen [GO:0005788]	calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]; calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:22265013}.
Q9NWN3	reviewed	FBX34_HUMAN	F-box only protein 34	FBXO34 FBX34	Homo sapiens (Human)	711	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.						
Q9NWQ4	reviewed	GPT2L_HUMAN	G patch domain-containing protein 2-like	GPATCH2L C14orf118 KIAA1152	Homo sapiens (Human)	482				nucleus [GO:0005634]		nucleus [GO:0005634]	
Q9NWQ8	reviewed	PHAG1_HUMAN	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)	PAG1 CBP PAG	Homo sapiens (Human)	432	FUNCTION: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}.		adaptive immune response [GO:0002250]; intracellular signal transduction [GO:0035556]; negative regulation of T cell activation [GO:0050868]; regulation of T cell activation [GO:0050863]; signal transduction [GO:0007165]	membrane raft [GO:0045121]; plasma membrane [GO:0005886]	SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]	membrane raft [GO:0045121]; plasma membrane [GO:0005886]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; adaptive immune response [GO:0002250]; intracellular signal transduction [GO:0035556]; negative regulation of T cell activation [GO:0050868]; regulation of T cell activation [GO:0050863]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:18070987}; Single-pass type III membrane protein {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:18070987}. Note=Present in lipid rafts.
Q9NWQ9	reviewed	CN119_HUMAN	Uncharacterized protein C14orf119	C14orf119 My028	Homo sapiens (Human)	140				cytosol [GO:0005829]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22361696}.
Q9NWR8	reviewed	MCUB_HUMAN	Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUb) (Coiled-coil domain-containing protein 109B)	MCUB CCDC109B	Homo sapiens (Human)	336	FUNCTION: Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. {ECO:0000250|UniProtKB:Q810S1}.		calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]	calcium channel complex [GO:0034704]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; uniplex complex [GO:1990246]	calcium channel inhibitor activity [GO:0019855]	calcium channel complex [GO:0034704]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; uniplex complex [GO:1990246]; calcium channel inhibitor activity [GO:0019855]; calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:24231807}; Multi-pass membrane protein {ECO:0000269|PubMed:24231807}.
Q9NWS0	reviewed	PIHD1_HUMAN	PIH1 domain-containing protein 1 (Nucleolar protein 17 homolog)	PIH1D1 NOP17	Homo sapiens (Human)	290	FUNCTION: Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451). {ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:20864032, ECO:0000269|PubMed:22368283, ECO:0000269|PubMed:24036451}.		box C/D snoRNP assembly [GO:0000492]; chromatin remodeling [GO:0006338]; epithelial cell differentiation [GO:0030855]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; protein stabilization [GO:0050821]; rRNA processing [GO:0006364]; snoRNA localization [GO:0048254]; TORC1 complex assembly [GO:1905669]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]	ATPase binding [GO:0051117]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; phosphoprotein binding [GO:0051219]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; ATPase binding [GO:0051117]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; phosphoprotein binding [GO:0051219]; protein kinase binding [GO:0019901]; box C/D snoRNP assembly [GO:0000492]; chromatin remodeling [GO:0006338]; epithelial cell differentiation [GO:0030855]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; protein stabilization [GO:0050821]; rRNA processing [GO:0006364]; snoRNA localization [GO:0048254]; TORC1 complex assembly [GO:1905669]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9CQJ2}.
Q9NWS1	reviewed	PARI_HUMAN	PCNA-interacting partner (PARI) (PARP-1 binding protein) (PARP1-binding protein) (PARPBP)	PARPBP C12orf48 PARI	Homo sapiens (Human)	579	FUNCTION: Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect. {ECO:0000269|PubMed:20931645, ECO:0000269|PubMed:22153967}.		DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20931645, ECO:0000269|PubMed:22153967}. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA.
Q9NWS6	reviewed	F118A_HUMAN	Protein FAM118A	FAM118A C22orf8	Homo sapiens (Human)	357				membrane [GO:0016020]	identical protein binding [GO:0042802]	membrane [GO:0016020]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NWS8	reviewed	RMND1_HUMAN	Required for meiotic nuclear division protein 1 homolog	RMND1 C6orf96	Homo sapiens (Human)	449	FUNCTION: Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome (PubMed:23022098, PubMed:25604853). {ECO:0000269|PubMed:23022098, ECO:0000269|PubMed:25604853}.		positive regulation of mitochondrial translation [GO:0070131]; translation [GO:0006412]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; positive regulation of mitochondrial translation [GO:0070131]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23022098, ECO:0000269|PubMed:23022099, ECO:0000269|PubMed:25604853}. Note=May be localized in mitochondrial RNA granules (PubMed:25604853). {ECO:0000269|PubMed:25604853}.
Q9NWS9	reviewed	ZN446_HUMAN	Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20)	ZNF446 ZKSCAN20	Homo sapiens (Human)	450	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; extracellular space [GO:0005615]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; extracellular space [GO:0005615]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q9NWT1	reviewed	PK1IP_HUMAN	p21-activated protein kinase-interacting protein 1 (PAK/PLC-interacting protein 1) (hPIP1) (PAK1-interacting protein 1) (WD repeat-containing protein 84)	PAK1IP1 PIP1 WDR84	Homo sapiens (Human)	392	FUNCTION: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868). {ECO:0000269|PubMed:11371639, ECO:0000269|PubMed:24120868}.		cell population proliferation [GO:0008283]; negative regulation of signal transduction [GO:0009968]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit biogenesis [GO:0042273]; roof of mouth development [GO:0060021]	nucleolus [GO:0005730]		nucleolus [GO:0005730]; cell population proliferation [GO:0008283]; negative regulation of signal transduction [GO:0009968]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit biogenesis [GO:0042273]; roof of mouth development [GO:0060021]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Q9NWT6	reviewed	HIF1N_HUMAN	Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase)	HIF1AN FIH1	Homo sapiens (Human)	349	FUNCTION: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}.		negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of vasculogenesis [GO:2001214]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	[protein]-asparagine 3-dioxygenase activity [GO:0036140]; ankyrin repeat binding [GO:0071532]; carboxylic acid binding [GO:0031406]; ferrous iron binding [GO:0008198]; NF-kappaB binding [GO:0051059]; Notch binding [GO:0005112]; oxygen sensor activity [GO:0019826]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; [protein]-asparagine 3-dioxygenase activity [GO:0036140]; ankyrin repeat binding [GO:0071532]; carboxylic acid binding [GO:0031406]; ferrous iron binding [GO:0008198]; NF-kappaB binding [GO:0051059]; Notch binding [GO:0005112]; oxygen sensor activity [GO:0019826]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of vasculogenesis [GO:2001214]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.
Q9NWT8	reviewed	AKIP_HUMAN	Small ribosomal subunit protein mS38 (28S ribosomal protein S38, mitochondrial) (MRP-S38) (Aurora kinase A-interacting protein) (AURKA-interacting protein)	AURKAIP1 AIP AKIP MRPS38	Homo sapiens (Human)	199	FUNCTION: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.		mitochondrial translation [GO:0032543]; negative regulation of mitotic nuclear division [GO:0045839]; positive regulation of proteolysis [GO:0045862]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mitochondrial translation [GO:0032543]; negative regulation of mitotic nuclear division [GO:0045839]; positive regulation of proteolysis [GO:0045862]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:23908630, ECO:0000269|PubMed:27184847}. Nucleus {ECO:0000269|PubMed:23908630}.
Q9NWU1	reviewed	OXSM_HUMAN	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase)	OXSM	Homo sapiens (Human)	459	FUNCTION: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. {ECO:0000269|PubMed:15668256}.		acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; medium-chain fatty acid biosynthetic process [GO:0051792]; short-chain fatty acid biosynthetic process [GO:0051790]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; medium-chain fatty acid biosynthetic process [GO:0051792]; short-chain fatty acid biosynthetic process [GO:0051790]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15668256}.
Q9NWU2	reviewed	GID8_HUMAN	Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1)	GID8 C20orf11 TWA1	Homo sapiens (Human)	228	FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046). {ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29911972}.		positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; Wnt signaling pathway [GO:0016055]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	protein homodimerization activity [GO:0042803]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; protein homodimerization activity [GO:0042803]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:28829046}. Nucleus {ECO:0000269|PubMed:12559565, ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29911972}. Note=Localizes in the cytoplasm in the absence of Wnt stimulation and in the nucleus in the presence of Wnt stimulation. {ECO:0000269|PubMed:28829046}.
Q9NWU5	reviewed	RM22_HUMAN	Large ribosomal subunit protein uL22m (39S ribosomal protein L22, mitochondrial) (L22mt) (MRP-L22) (39S ribosomal protein L25, mitochondrial) (L25mt) (MRP-L25)	MRPL22 MRPL25 RPML25 HSPC158	Homo sapiens (Human)	206			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:28892042}.
Q9NWV8	reviewed	BABA1_HUMAN	BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex)	BABAM1 C19orf62 MERIT40 NBA1 HSPC142	Homo sapiens (Human)	329	FUNCTION: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}.		cell division [GO:0051301]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; hematopoietic stem cell proliferation [GO:0071425]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of DNA repair [GO:0045739]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]	BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell division [GO:0051301]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; hematopoietic stem cell proliferation [GO:0071425]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of DNA repair [GO:0045739]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:24075985}. Nucleus {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:21282113, ECO:0000269|PubMed:24075985}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:21282113}.
Q9NWW5	reviewed	CLN6_HUMAN	Ceroid-lipofuscinosis neuronal protein 6 (Protein CLN6)	CLN6	Homo sapiens (Human)	311			cholesterol metabolic process [GO:0008203]; ganglioside metabolic process [GO:0001573]; glycosaminoglycan metabolic process [GO:0030203]; locomotion involved in locomotory behavior [GO:0031987]; lysosomal lumen acidification [GO:0007042]; lysosome organization [GO:0007040]; positive regulation of proteolysis [GO:0045862]; protein catabolic process [GO:0030163]; visual perception [GO:0007601]	early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleolus [GO:0005730]	lysophosphatidic acid binding [GO:0035727]; protein homodimerization activity [GO:0042803]; sulfatide binding [GO:0120146]	early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleolus [GO:0005730]; lysophosphatidic acid binding [GO:0035727]; protein homodimerization activity [GO:0042803]; sulfatide binding [GO:0120146]; cholesterol metabolic process [GO:0008203]; ganglioside metabolic process [GO:0001573]; glycosaminoglycan metabolic process [GO:0030203]; locomotion involved in locomotory behavior [GO:0031987]; lysosomal lumen acidification [GO:0007042]; lysosome organization [GO:0007040]; positive regulation of proteolysis [GO:0045862]; protein catabolic process [GO:0030163]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15265688}; Multi-pass membrane protein {ECO:0000269|PubMed:15265688}. Endoplasmic reticulum {ECO:0000269|PubMed:19941651}.
Q9NWW6	reviewed	NRK1_HUMAN	Nicotinamide riboside kinase 1 (NRK 1) (NmR-K 1) (EC 2.7.1.22) (Nicotinic acid riboside kinase 1) (EC 2.7.1.173) (Ribosylnicotinamide kinase 1) (RNK 1) (Ribosylnicotinic acid kinase 1)	NMRK1 C9orf95 NRK1	Homo sapiens (Human)	199	FUNCTION: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine. {ECO:0000269|PubMed:15137942}.		NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; ribosylnicotinamide kinase activity [GO:0050262]; ribosylnicotinate kinase activity [GO:0061769]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; ribosylnicotinamide kinase activity [GO:0050262]; ribosylnicotinate kinase activity [GO:0061769]; NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674]; phosphorylation [GO:0016310]	
Q9NWW9	reviewed	PLAT2_HUMAN	Phospholipase A and acyltransferase 2 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 2)	PLAAT2 HRASLS2	Homo sapiens (Human)	162	FUNCTION: Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22825852, PubMed:22605381). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22825852, PubMed:22605381). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor (PubMed:22605381). Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity (PubMed:22825852). {ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:22605381, ECO:0000269|PubMed:22825852, ECO:0000303|PubMed:26503625}.		lipid catabolic process [GO:0016042]; localization [GO:0051179]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; acyltransferase activity [GO:0016746]; N-acyltransferase activity [GO:0016410]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; acyltransferase activity [GO:0016746]; N-acyltransferase activity [GO:0016410]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]; lipid catabolic process [GO:0016042]; localization [GO:0051179]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18163183}. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Note=Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization. {ECO:0000269|PubMed:18163183}.
Q9NWX5	reviewed	ASB6_HUMAN	Ankyrin repeat and SOCS box protein 6 (ASB-6)	ASB6	Homo sapiens (Human)	421	FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:16325183}.		intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]		cytosol [GO:0005829]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9NWX6	reviewed	THG1_HUMAN	Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (Induced in high glucose-1) (IHG-1) (Interphase cytoplasmic foci protein 45) (tRNA-histidine guanylyltransferase)	THG1L ICF45	Homo sapiens (Human)	298	FUNCTION: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion (PubMed:25008184, PubMed:27307223). By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress (PubMed:25008184, PubMed:27307223). {ECO:0000269|PubMed:25008184, ECO:0000269|PubMed:27307223, ECO:0000305|PubMed:21059936}.		mitochondrial fusion [GO:0008053]; protein homotetramerization [GO:0051289]; response to oxidative stress [GO:0006979]; stress-induced mitochondrial fusion [GO:1990046]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; transferase complex [GO:1990234]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]; tRNA guanylyltransferase activity [GO:0008193]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; transferase complex [GO:1990234]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]; tRNA guanylyltransferase activity [GO:0008193]; mitochondrial fusion [GO:0008053]; protein homotetramerization [GO:0051289]; response to oxidative stress [GO:0006979]; stress-induced mitochondrial fusion [GO:1990046]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15459185}. Mitochondrion outer membrane {ECO:0000305|PubMed:25008184}.
Q9NWY4	reviewed	HPF1_HUMAN	Histone PARylation factor 1	HPF1 C4orf27	Homo sapiens (Human)	346	FUNCTION: Cofactor for serine ADP-ribosylation that confers serine specificity on PARP1 and PARP2 and plays a key role in DNA damage response (PubMed:28190768, PubMed:29480802, PubMed:29954836, PubMed:33186521, PubMed:32028527, PubMed:32939087, PubMed:34486521, PubMed:34874266, PubMed:34210965, PubMed:34625544, PubMed:33589610, PubMed:34732825, PubMed:33683197, PubMed:34795260, PubMed:34108479). Initiates the repair of double-strand DNA breaks: recruited to DNA damage sites by PARP1 and PARP2 and switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins (PubMed:28190768, PubMed:29480802, PubMed:29954836, PubMed:32028527, PubMed:32939087, PubMed:34486521, PubMed:34874266, PubMed:34625544, PubMed:33589610, PubMed:34732825, PubMed:33683197, PubMed:34795260). Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:27067600, PubMed:28190768, PubMed:32939087, PubMed:33589610). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). HPF1 acts by completing the active site of PARP1 and PARP2: forms a composite active site composed of residues from HPF1 and PARP1 or PARP2 (PubMed:32028527, PubMed:33589610). While HPF1 promotes the initiation of serine ADP-ribosylation, it restricts the polymerase activity of PARP1 and PARP2 in order to limit the length of poly-ADP-ribose chains (PubMed:34732825, PubMed:33683197, PubMed:34795260). HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1 (PubMed:29954836, PubMed:30257210). {ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29480802, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32939087, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34108479, ECO:0000269|PubMed:34210965, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; regulation of protein ADP-ribosylation [GO:0010835]	chromatin [GO:0000785]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; poly-ADP-D-ribose binding [GO:0072572]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]	chromatin [GO:0000785]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; poly-ADP-D-ribose binding [GO:0072572]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; regulation of protein ADP-ribosylation [GO:0010835]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:32939087}. Nucleus {ECO:0000269|PubMed:27067600}. Note=Localizes to DNA damage sites; chromatin localization is dependent on PARP1 and PARP2. {ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:32939087}.
Q9NWZ3	reviewed	IRAK4_HUMAN	Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)	IRAK4	Homo sapiens (Human)	460	FUNCTION: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}.		cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; phosphorylation [GO:0016310]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of smooth muscle cell proliferation [GO:0048661]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular space [GO:0005615]; extrinsic component of plasma membrane [GO:0019897]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; interleukin-1 receptor binding [GO:0005149]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular space [GO:0005615]; extrinsic component of plasma membrane [GO:0019897]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; interleukin-1 receptor binding [GO:0005149]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; phosphorylation [GO:0016310]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of smooth muscle cell proliferation [GO:0048661]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21325272}.
Q9NWZ5	reviewed	UCKL1_HUMAN	Uridine-cytidine kinase-like 1 (EC 2.7.1.48)	UCKL1 URKL1 F538	Homo sapiens (Human)	548	FUNCTION: May contribute to UTP accumulation needed for blast transformation and proliferation. {ECO:0000269|PubMed:12199906}.		CTP salvage [GO:0044211]; phosphorylation [GO:0016310]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; uridine kinase activity [GO:0004849]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; uridine kinase activity [GO:0004849]; CTP salvage [GO:0044211]; phosphorylation [GO:0016310]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12199906}. Nucleus {ECO:0000269|PubMed:12199906}. Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.
Q9NWZ8	reviewed	GEMI8_HUMAN	Gem-associated protein 8 (Gemin-8) (Protein FAM51A1)	GEMIN8 FAM51A1	Homo sapiens (Human)	242	FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:17023415, ECO:0000269|PubMed:18984161}.		spliceosomal snRNP assembly [GO:0000387]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Nucleus, gem {ECO:0000269|PubMed:16434402}. Cytoplasm {ECO:0000269|PubMed:16434402}. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Q9NX01	reviewed	TXN4B_HUMAN	Thioredoxin-like protein 4B (Dim1-like protein)	TXNL4B DIM2 DLP	Homo sapiens (Human)	149	FUNCTION: Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition. {ECO:0000269|PubMed:15161931}.		cell cycle [GO:0007049]; mRNA splicing, via spliceosome [GO:0000398]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; cell cycle [GO:0007049]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15161931}.
Q9NX02	reviewed	NALP2_HUMAN	NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2)	NLRP2 NALP2 NBS1 PAN1 PYPAF2	Homo sapiens (Human)	1062	FUNCTION: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases. {ECO:0000269|PubMed:15456791}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	apoptotic process [GO:0006915]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of interleukin-1 beta production [GO:0032731]; regulation of inflammatory response [GO:0050727]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]	ATP binding [GO:0005524]; Pyrin domain binding [GO:0032090]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; ATP binding [GO:0005524]; Pyrin domain binding [GO:0032090]; apoptotic process [GO:0006915]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of interleukin-1 beta production [GO:0032731]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:15456791}.
Q9NX04	reviewed	AIRIM_HUMAN	AFG2-interacting ribosome maturation factor (Ribosome biogenesis protein C1orf109)	AIRIM C1orf109	Homo sapiens (Human)	203	FUNCTION: Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). Acts together with AFG2A, AFG2B and CINP (PubMed:35354024). {ECO:0000269|PubMed:35354024}.		ribosomal large subunit biogenesis [GO:0042273]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosomal large subunit biogenesis [GO:0042273]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22548824}. Cytoplasm {ECO:0000269|PubMed:22548824}.
Q9NX07	reviewed	TSAP1_HUMAN	tRNA selenocysteine 1-associated protein 1 (SECp43) (tRNA selenocysteine-associated protein 1)	TRNAU1AP SECP43 TRSPAP1	Homo sapiens (Human)	287	FUNCTION: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16508009}.		selenocysteine incorporation [GO:0001514]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	RNA binding [GO:0003723]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]; selenocysteine incorporation [GO:0001514]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Abundant in the nucleus. {ECO:0000250}.
Q9NX09	reviewed	DDIT4_HUMAN	DNA damage-inducible transcript 4 protein (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1)	DDIT4 REDD1 RTP801	Homo sapiens (Human)	232	FUNCTION: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. {ECO:0000250, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201, ECO:0000269|PubMed:15988001, ECO:0000269|PubMed:17005863, ECO:0000269|PubMed:17379067, ECO:0000269|PubMed:19557001, ECO:0000269|PubMed:20166753, ECO:0000269|PubMed:21460850}.		apoptotic process [GO:0006915]; brain development [GO:0007420]; cellular response to dexamethasone stimulus [GO:0071549]; defense response to virus [GO:0051607]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of glycolytic process [GO:0045820]; negative regulation of TOR signaling [GO:0032007]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neurotrophin TRK receptor signaling pathway [GO:0048011]; protein-containing complex disassembly [GO:0032984]; reactive oxygen species metabolic process [GO:0072593]; response to hypoxia [GO:0001666]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	14-3-3 protein binding [GO:0071889]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; 14-3-3 protein binding [GO:0071889]; apoptotic process [GO:0006915]; brain development [GO:0007420]; cellular response to dexamethasone stimulus [GO:0071549]; defense response to virus [GO:0051607]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of glycolytic process [GO:0045820]; negative regulation of TOR signaling [GO:0032007]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neurotrophin TRK receptor signaling pathway [GO:0048011]; protein-containing complex disassembly [GO:0032984]; reactive oxygen species metabolic process [GO:0072593]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:12453409}.
Q9NX14	reviewed	NDUBB_HUMAN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (CI-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit) (Neuronal protein 17.3) (Np17.3) (p17.3)	NDUFB11 UNQ111/PRO1064	Homo sapiens (Human)	153	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; aerobic respiration [GO:0009060]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:31206022, ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000305}. Note=The interaction with BCAP31 mediates mitochondria localization. {ECO:0000269|PubMed:31206022}.
Q9NX18	reviewed	SDHF2_HUMAN	Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2)	SDHAF2 C11orf79 PGL2 SDH5	Homo sapiens (Human)	166	FUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. {ECO:0000255|HAMAP-Rule:MF_03057, ECO:0000269|PubMed:19628817}.		mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; mitochondrial respiratory chain complex II assembly [GO:0034553]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; protein dephosphorylation [GO:0006470]; protein-FAD linkage [GO:0018293]; tricarboxylic acid cycle [GO:0006099]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]		cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; mitochondrial respiratory chain complex II assembly [GO:0034553]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; protein dephosphorylation [GO:0006470]; protein-FAD linkage [GO:0018293]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03057, ECO:0000269|PubMed:19628817}.
Q9NX24	reviewed	NHP2_HUMAN	H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2)	NHP2 NOLA2 HSPC286	Homo sapiens (Human)	153	FUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:15044956}.		maturation of LSU-rRNA [GO:0000470]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; rRNA pseudouridine synthesis [GO:0031118]; snRNA pseudouridine synthesis [GO:0031120]; telomere maintenance via telomerase [GO:0007004]	box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; chromosome, telomeric region [GO:0000781]; cytosolic large ribosomal subunit [GO:0022625]; nucleoplasm [GO:0005654]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; telomerase holoenzyme complex [GO:0005697]	box H/ACA snoRNA binding [GO:0034513]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; chromosome, telomeric region [GO:0000781]; cytosolic large ribosomal subunit [GO:0022625]; nucleoplasm [GO:0005654]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; telomerase holoenzyme complex [GO:0005697]; box H/ACA snoRNA binding [GO:0034513]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; maturation of LSU-rRNA [GO:0000470]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; rRNA pseudouridine synthesis [GO:0031118]; snRNA pseudouridine synthesis [GO:0031120]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
Q9NX40	reviewed	OCAD1_HUMAN	OCIA domain-containing protein 1 (Ovarian cancer immunoreactive antigen domain containing 1) (Ovarian carcinoma immunoreactive antigen)	OCIAD1 ASRIJ OCIA	Homo sapiens (Human)	245	FUNCTION: Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946). {ECO:0000250|UniProtKB:Q9CRD0, ECO:0000269|PubMed:20515946}.	MISCELLANEOUS: 'Asrij' stands for 'blood' in Sanskrit as this protein is strongly expressed in blood vessels.	endocytosis [GO:0006897]; hematopoietic stem cell homeostasis [GO:0061484]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of stem cell differentiation [GO:2000736]	endosome [GO:0005768]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane [GO:0016020]		endosome [GO:0005768]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane [GO:0016020]; endocytosis [GO:0006897]; hematopoietic stem cell homeostasis [GO:0061484]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of stem cell differentiation [GO:2000736]	SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:Q9CRD0}.
Q9NX46	reviewed	ADPRS_HUMAN	ADP-ribosylhydrolase ARH3 (ADP-ribose glycohydrolase ARH3) (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-)	ADPRS ADPRHL2 ARH3	Homo sapiens (Human)	363	FUNCTION: ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose (PubMed:21498885, PubMed:30830864, PubMed:33769608, PubMed:30045870, PubMed:29907568, PubMed:34321462, PubMed:30401461, PubMed:33186521, PubMed:34019811, PubMed:33894202, PubMed:34479984, PubMed:34625544). Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response (PubMed:28650317, PubMed:29234005, PubMed:33186521, PubMed:34625544, PubMed:30045870, PubMed:34019811). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802, PubMed:33186521, PubMed:34625544). Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds (PubMed:16278211, PubMed:33769608). Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (PubMed:16278211). Also hydrolyzes free poly(ADP-ribose) in mitochondria (PubMed:22433848). Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins (PubMed:17075046, PubMed:21498885). Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers (PubMed:21498885). {ECO:0000269|PubMed:16278211, ECO:0000269|PubMed:17075046, ECO:0000269|PubMed:21498885, ECO:0000269|PubMed:22433848, ECO:0000269|PubMed:28650317, ECO:0000269|PubMed:29234005, ECO:0000269|PubMed:29480802, ECO:0000269|PubMed:29907568, ECO:0000269|PubMed:30045870, ECO:0000269|PubMed:30401461, ECO:0000269|PubMed:30830864, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33769608, ECO:0000269|PubMed:33894202, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462, ECO:0000269|PubMed:34479984, ECO:0000269|PubMed:34625544}.		base-excision repair, gap-filling [GO:0006287]; cellular response to superoxide [GO:0071451]; DNA repair [GO:0006281]; negative regulation of necroptotic process [GO:0060546]; peptidyl-serine ADP-deribosylation [GO:0140290]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	ADP-ribosylserine hydrolase activity [GO:0140292]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; magnesium ion binding [GO:0000287]; O-acetyl-ADP-ribose deacetylase activity [GO:0061463]; poly(ADP-ribose) glycohydrolase activity [GO:0004649]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; ADP-ribosylserine hydrolase activity [GO:0140292]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; magnesium ion binding [GO:0000287]; O-acetyl-ADP-ribose deacetylase activity [GO:0061463]; poly(ADP-ribose) glycohydrolase activity [GO:0004649]; base-excision repair, gap-filling [GO:0006287]; cellular response to superoxide [GO:0071451]; DNA repair [GO:0006281]; negative regulation of necroptotic process [GO:0060546]; peptidyl-serine ADP-deribosylation [GO:0140290]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17991898, ECO:0000269|PubMed:34479984}. Cytoplasm {ECO:0000269|PubMed:16278211, ECO:0000269|PubMed:34479984}. Chromosome {ECO:0000269|PubMed:30045870}. Mitochondrion matrix {ECO:0000269|PubMed:17991898, ECO:0000269|PubMed:34479984, ECO:0000305|PubMed:22433848}. Note=Recruited to DNA lesion regions following DNA damage; ADP-D-ribose-recognition is required for recruitment to DNA damage sites. {ECO:0000269|PubMed:30045870}.
Q9NX47	reviewed	MARH5_HUMAN	E3 ubiquitin-protein ligase MARCHF5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCHF5)	MARCHF5 MARCH5 RNF153	Homo sapiens (Human)	278	FUNCTION: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. {ECO:0000269|PubMed:16874301, ECO:0000269|PubMed:17606867, ECO:0000269|PubMed:19741096, ECO:0000269|PubMed:20103533}.	MISCELLANEOUS: By binding to and ubiquitinating two ALS1 variants of SOD1 (mSOD1 variants Arg-86 and Ala-94) it attenuates their cytotoxicity.	positive regulation of mitochondrial fission [GO:0090141]; protein autoubiquitination [GO:0051865]; protein localization to mitochondrion [GO:0070585]; protein polyubiquitination [GO:0000209]; regulation of mitochondrial fission [GO:0090140]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GTPase binding [GO:0051020]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; GTPase binding [GO:0051020]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; positive regulation of mitochondrial fission [GO:0090141]; protein autoubiquitination [GO:0051865]; protein localization to mitochondrion [GO:0070585]; protein polyubiquitination [GO:0000209]; regulation of mitochondrial fission [GO:0090140]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:16874301}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301). {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:16874301}.
Q9NX52	reviewed	RHBL2_HUMAN	Rhomboid-related protein 2 (RRP2) (EC 3.4.21.105) (Rhomboid-like protein 2) [Cleaved into: Rhomboid-related protein 2, N-terminal fragment (NTF); Rhomboid-related protein 2, C-terminal fragment (CTF)]	RHBDL2	Homo sapiens (Human)	303	FUNCTION: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3. {ECO:0000269|PubMed:11672525, ECO:0000269|PubMed:15047175}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	proteolysis [GO:0006508]	plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]	plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: [Rhomboid-related protein 2, C-terminal fragment]: Cell membrane {ECO:0000269|PubMed:19850051}; Multi-pass membrane protein {ECO:0000255}.
Q9NX55	reviewed	HYPK_HUMAN	Huntingtin-interacting protein K (Huntingtin yeast partner K)	HYPK C15orf63 HSPC136	Homo sapiens (Human)	121	FUNCTION: Component of several N-terminal acetyltransferase complexes (PubMed:20154145, PubMed:29754825, PubMed:32042062). Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex) (PubMed:29754825, PubMed:32042062). Has chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT in neuronal cells probably while associated with the NatA complex (PubMed:17947297, PubMed:20154145). May play a role in the NatA complex-mediated N-terminal acetylation of PCNP (PubMed:20154145). {ECO:0000269|PubMed:17947297, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}.		negative regulation of apoptotic process [GO:0043066]; protein stabilization [GO:0050821]	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	protein folding chaperone [GO:0044183]	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein folding chaperone [GO:0044183]; negative regulation of apoptotic process [GO:0043066]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20154145}. Cytoplasm {ECO:0000269|PubMed:20154145}. Note=Within the NatA/HYPK complex, may localize to ribosomes. {ECO:0000269|PubMed:20154145}.
Q9NX57	reviewed	RAB20_HUMAN	Ras-related protein Rab-20	RAB20	Homo sapiens (Human)	234	FUNCTION: Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. {ECO:0000269|PubMed:21255211}.		cellular response to type II interferon [GO:0071346]; intracellular protein transport [GO:0006886]; phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]	endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cellular response to type II interferon [GO:0071346]; intracellular protein transport [GO:0006886]; phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:16613320}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000250|UniProtKB:P35295, ECO:0000269|PubMed:21255211}.
Q9NX58	reviewed	LYAR_HUMAN	Cell growth-regulating nucleolar protein	LYAR PNAS-5	Homo sapiens (Human)	379	FUNCTION: Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity). {ECO:0000250|UniProtKB:Q08288, ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:28686580, ECO:0000269|PubMed:31413131}.		erythrocyte development [GO:0048821]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of phagocytosis [GO:0050766]; positive regulation of transcription by RNA polymerase I [GO:0045943]; rRNA processing [GO:0006364]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor outer segment [GO:0001750]	DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription regulator inhibitor activity [GO:0140416]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor outer segment [GO:0001750]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription regulator inhibitor activity [GO:0140416]; erythrocyte development [GO:0048821]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of phagocytosis [GO:0050766]; positive regulation of transcription by RNA polymerase I [GO:0045943]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:31413131}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:24495227}. Cytoplasm {ECO:0000269|PubMed:24990247}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q08288}. Note=Component of pre-ribosomal particles, including pre-40S, pre-60S and pre-90S (PubMed:24495227). Associated with cytoplasmic ribosomes, but not polysomes, as a component of the 60S subunit (PubMed:24990247). In the retina, predominantly expressed in photoreceptor outer segments (By similarity). In the nucleolus, colocalizes with nucleolin/NCL, therefore may reside in the dense fibrillar component (DFC) (By similarity). {ECO:0000250|UniProtKB:Q08288, ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:24990247}.
Q9NX61	reviewed	T161A_HUMAN	Transmembrane protein 161A (Adaptive response to oxidative stress protein 29) (AROS-29)	TMEM161A UNQ582/PRO1152	Homo sapiens (Human)	479	FUNCTION: May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. {ECO:0000269|PubMed:16551573}.		cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; positive regulation of DNA repair [GO:0045739]; response to retinoic acid [GO:0032526]	membrane [GO:0016020]		membrane [GO:0016020]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; positive regulation of DNA repair [GO:0045739]; response to retinoic acid [GO:0032526]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NX62	reviewed	IMPA3_HUMAN	Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (Golgi-resident PAP phosphatase) (gPAPP) (EC 3.1.3.7) (3'(2'), 5'-bisphosphate nucleotidase 2) (Inositol monophosphatase domain-containing protein 1) (Myo-inositol monophosphatase A3) (Phosphoadenosine phosphate 3'-nucleotidase)	BPNT2 IMPA3 IMPAD1	Homo sapiens (Human)	359	FUNCTION: Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4. {ECO:0000250|UniProtKB:Q80V26}.		chondrocyte development [GO:0002063]; chondroitin sulfate metabolic process [GO:0030204]; embryonic digit morphogenesis [GO:0042733]; endochondral ossification [GO:0001958]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; post-embryonic development [GO:0009791]; skeletal system development [GO:0001501]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; trans-Golgi network membrane [GO:0032588]	3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; 3',5'-nucleotide bisphosphate phosphatase activity [GO:0097657]; 3'-nucleotidase activity [GO:0008254]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; trans-Golgi network membrane [GO:0032588]; 3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; 3',5'-nucleotide bisphosphate phosphatase activity [GO:0097657]; 3'-nucleotidase activity [GO:0008254]; metal ion binding [GO:0046872]; chondrocyte development [GO:0002063]; chondroitin sulfate metabolic process [GO:0030204]; embryonic digit morphogenesis [GO:0042733]; endochondral ossification [GO:0001958]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; post-embryonic development [GO:0009791]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:18695242}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18695242}; Single-pass type II membrane protein {ECO:0000255, ECO:0000269|PubMed:18695242}. Note=The catalytic core is predicted to reside within the Golgi lumen. {ECO:0000269|PubMed:18695242}.
Q9NX63	reviewed	MIC19_HUMAN	MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3)	CHCHD3 MIC19 MINOS3	Homo sapiens (Human)	227	FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180}.		cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial fusion [GO:0008053]	extracellular exosome [GO:0070062]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; SAM complex [GO:0001401]	molecular adaptor activity [GO:0060090]; phosphatase binding [GO:0019902]	extracellular exosome [GO:0070062]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; SAM complex [GO:0001401]; molecular adaptor activity [GO:0060090]; phosphatase binding [GO:0019902]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial fusion [GO:0008053]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9CRB9}; Lipid-anchor {ECO:0000305}; Intermembrane side {ECO:0000250|UniProtKB:Q9CRB9}. Cytoplasm {ECO:0000269|PubMed:22567091}. Nucleus {ECO:0000269|PubMed:22567091}. Mitochondrion {ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:25997101}.
Q9NX65	reviewed	ZSC32_HUMAN	Zinc finger and SCAN domain-containing protein 32 (Human cervical cancer suppressor gene 5 protein) (HCCS-5) (Zinc finger protein 434)	ZSCAN32 ZNF434 HCCS5	Homo sapiens (Human)	697	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q9NX70	reviewed	MED29_HUMAN	Mediator of RNA polymerase II transcription subunit 29 (Intersex-like protein) (Mediator complex subunit 29)	MED29 IXL	Homo sapiens (Human)	200	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15555573}.		positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coregulator activity [GO:0003712]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15555573}.
Q9NX74	reviewed	DUS2L_HUMAN	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2)	DUS2 DUS2L	Homo sapiens (Human)	493	FUNCTION: Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704, PubMed:34798057). Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616). {ECO:0000269|PubMed:15994936, ECO:0000269|PubMed:18096616, ECO:0000269|PubMed:26429968, ECO:0000269|PubMed:30149704, ECO:0000269|PubMed:34798057}.		antiviral innate immune response [GO:0140374]; tRNA dihydrouridine synthesis [GO:0002943]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]	double-stranded RNA binding [GO:0003725]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADPH binding [GO:0070402]; protein kinase inhibitor activity [GO:0004860]; tRNA binding [GO:0000049]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine20 synthase activity [GO:0102264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; double-stranded RNA binding [GO:0003725]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADPH binding [GO:0070402]; protein kinase inhibitor activity [GO:0004860]; tRNA binding [GO:0000049]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine20 synthase activity [GO:0102264]; antiviral innate immune response [GO:0140374]; tRNA dihydrouridine synthesis [GO:0002943]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15994936}. Endoplasmic reticulum {ECO:0000269|PubMed:15994936}. Note=Mainly at the endoplasmic reticulum. {ECO:0000269|PubMed:15994936}.
Q9NX76	reviewed	CKLF6_HUMAN	CKLF-like MARVEL transmembrane domain-containing protein 6 (Chemokine-like factor superfamily member 6)	CMTM6 CKLFSF6	Homo sapiens (Human)	183	FUNCTION: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. {ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}.		endocytic recycling [GO:0032456]; protein transport [GO:0015031]; regulation of protein stability [GO:0031647]	azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule membrane [GO:0035579]		azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule membrane [GO:0035579]; endocytic recycling [GO:0032456]; protein transport [GO:0015031]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:28813417}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:28813417}; Multi-pass membrane protein {ECO:0000255}. Note=Co-localizes with PD-L1/CD274 in the plasma membrane and in recycling endosomes. {ECO:0000269|PubMed:28813417}.
Q9NX78	reviewed	TM260_HUMAN	Protein O-mannosyl-transferase TMEM260 (EC 2.4.1.109) (Transmembrane protein 260)	TMEM260 C14orf101	Homo sapiens (Human)	707	FUNCTION: O-mannosyl-transferase that transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins (PubMed:37186866). Specifically glycosylates the IPT/TIG domain of target proteins, such as MET and MST1R/RON (PubMed:37186866). TMEM260-mediated O-mannosylated residues are composed of single mannose glycans that are not elongated or modified (PubMed:37186866). {ECO:0000269|PubMed:37186866}.		protein maturation [GO:0051604]	endoplasmic reticulum membrane [GO:0005789]	dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]	endoplasmic reticulum membrane [GO:0005789]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; protein maturation [GO:0051604]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:37186866}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Membrane {ECO:0000269|PubMed:28318500}. Note=Shows perinuclear localization. {ECO:0000269|PubMed:28318500}.
Q9NX94	reviewed	WBP1L_HUMAN	WW domain binding protein 1-like (Outcome predictor in acute leukemia 1)	WBP1L C10orf26 OPA1L	Homo sapiens (Human)	342			CXCL12-activated CXCR4 signaling pathway [GO:0038160]; hemopoiesis [GO:0030097]; positive regulation of protein ubiquitination [GO:0031398]	membrane [GO:0016020]	ubiquitin protein ligase binding [GO:0031625]	membrane [GO:0016020]; ubiquitin protein ligase binding [GO:0031625]; CXCL12-activated CXCR4 signaling pathway [GO:0038160]; hemopoiesis [GO:0030097]; positive regulation of protein ubiquitination [GO:0031398]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NX95	reviewed	SYBU_HUMAN	Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein)	SYBU GOLSYN KIAA1472	Homo sapiens (Human)	663	FUNCTION: Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}.		anterograde neuronal dense core vesicle transport [GO:1990048]; axonal transport of mitochondrion [GO:0019896]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; regulation of synaptic activity [GO:0060025]; synapse maturation [GO:0060074]	axon cytoplasm [GO:1904115]; cytoplasmic microtubule [GO:0005881]; cytoplasmic vesicle [GO:0031410]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]		axon cytoplasm [GO:1904115]; cytoplasmic microtubule [GO:0005881]; cytoplasmic vesicle [GO:0031410]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; anterograde neuronal dense core vesicle transport [GO:1990048]; axonal transport of mitochondrion [GO:0019896]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; regulation of synaptic activity [GO:0060025]; synapse maturation [GO:0060074]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Note=Colocalizes with syntaxin vesicles along microtubules in neuronal processes.; SUBCELLULAR LOCATION: [Isoform 3]: Golgi apparatus membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Golgi apparatus membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 5]: Golgi apparatus membrane; Single-pass membrane protein.
Q9NXA8	reviewed	SIR5_HUMAN	NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)	SIRT5 SIR2L5	Homo sapiens (Human)	310	FUNCTION: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. {ECO:0000250|UniProtKB:Q8K2C6, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:21908771, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:24140062, ECO:0000269|PubMed:24703693, ECO:0000269|PubMed:29180469}.	MISCELLANEOUS: The mechanism of demalonylation and desuccinylation involves the presence of a 1',2'-cyclic intermediate, suggesting that sirtuins use the ADP-ribose-peptidylamidate mechanism to remove acyl groups from substrate lysine residues. {ECO:0000305|PubMed:22767592}.	mitochondrion organization [GO:0007005]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-lysine demalonylation [GO:0036047]; peptidyl-lysine desuccinylation [GO:0036049]; protein deacetylation [GO:0006476]; protein deglutarylation [GO:0061698]; protein demalonylation [GO:0036046]; protein desuccinylation [GO:0036048]; regulation of ketone biosynthetic process [GO:0010566]; response to nutrient levels [GO:0031667]	cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	NAD+ binding [GO:0070403]; NAD-dependent protein deacetylase activity [GO:0034979]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-succinyllysine desuccinylase activity [GO:0036055]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; NAD+ binding [GO:0070403]; NAD-dependent protein deacetylase activity [GO:0034979]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-succinyllysine desuccinylase activity [GO:0036055]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; mitochondrion organization [GO:0007005]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-lysine demalonylation [GO:0036047]; peptidyl-lysine desuccinylation [GO:0036049]; protein deacetylation [GO:0006476]; protein deglutarylation [GO:0061698]; protein demalonylation [GO:0036046]; protein desuccinylation [GO:0036048]; regulation of ketone biosynthetic process [GO:0010566]; response to nutrient levels [GO:0031667]	SUBCELLULAR LOCATION: Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:21143562}. Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:21143562}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:21143562}.
Q9NXB0	reviewed	MKS1_HUMAN	Tectonic-like complex member MKS1 (Meckel syndrome type 1 protein)	MKS1	Homo sapiens (Human)	559	FUNCTION: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. {ECO:0000269|PubMed:17185389, ECO:0000269|PubMed:19515853, ECO:0000269|PubMed:26490104}.		branching morphogenesis of an epithelial tube [GO:0048754]; cardiac septum morphogenesis [GO:0060411]; cilium assembly [GO:0060271]; common bile duct development [GO:0061009]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; epithelial structure maintenance [GO:0010669]; head development [GO:0060322]; inner ear receptor cell stereocilium organization [GO:0060122]; motile cilium assembly [GO:0044458]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901620]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003271]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; MKS complex [GO:0036038]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; MKS complex [GO:0036038]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac septum morphogenesis [GO:0060411]; cilium assembly [GO:0060271]; common bile duct development [GO:0061009]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; epithelial structure maintenance [GO:0010669]; head development [GO:0060322]; inner ear receptor cell stereocilium organization [GO:0060122]; motile cilium assembly [GO:0044458]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901620]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003271]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000269|PubMed:26490104}.
Q9NXB9	reviewed	ELOV2_HUMAN	Elongation of very long chain fatty acids protein 2 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL2) (ELOVL fatty acid elongase 2) (ELOVL FA elongase 2) (Very long chain 3-ketoacyl-CoA synthase 2) (Very long chain 3-oxoacyl-CoA synthase 2)	ELOVL2 ELG3 SSC2	Homo sapiens (Human)	296	FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03202, ECO:0000269|PubMed:11734209, ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:19575253, ECO:0000269|PubMed:20937905}.		alpha-linolenic acid metabolic process [GO:0036109]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; linoleic acid metabolic process [GO:0043651]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	fatty acid elongase activity [GO:0009922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fatty acid elongase activity [GO:0009922]; alpha-linolenic acid metabolic process [GO:0036109]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; linoleic acid metabolic process [GO:0043651]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03202, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03202}.
Q9NXC2	reviewed	GFOD1_HUMAN	Glucose-fructose oxidoreductase domain-containing protein 1 (EC 1.-.-.-)	GFOD1 C6orf114	Homo sapiens (Human)	390		MISCELLANEOUS: [Isoform 3]: Dubious isoform. {ECO:0000305}.		extracellular region [GO:0005576]	nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]; nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9NXC5	reviewed	MIOS_HUMAN	GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog)	MIOS	Homo sapiens (Human)	875	FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:26586190, PubMed:27487210, PubMed:36528027, PubMed:35831510). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:26586190, PubMed:27487210, PubMed:36528027, PubMed:35831510). GATOR2 probably acts as a E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25263562, PubMed:25457612, PubMed:26586190, PubMed:27487210). Within the GATOR2 complex, MIOS is required to prevent autoubiquitination of WDR24, the catalytic subunit of the complex (PubMed:35831510). The GATOR2 complex is required for brain myelination (By similarity). {ECO:0000250|UniProtKB:Q8VE19, ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26586190, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}.		cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; central nervous system myelin formation [GO:0032289]; negative regulation of TORC1 signaling [GO:1904262]; oligodendrocyte differentiation [GO:0048709]; oligodendrocyte progenitor proliferation [GO:0070444]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein-containing complex localization [GO:0031503]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]		cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; central nervous system myelin formation [GO:0032289]; negative regulation of TORC1 signaling [GO:1904262]; oligodendrocyte differentiation [GO:0048709]; oligodendrocyte progenitor proliferation [GO:0070444]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein-containing complex localization [GO:0031503]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28199306}.
Q9NXE4	reviewed	NSMA3_HUMAN	Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III)	SMPD4 KIAA1418 SKNY	Homo sapiens (Human)	866	FUNCTION: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function (PubMed:31495489). May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924). In skeletal muscle, mediates TNF-stimulated oxidant production (By similarity). {ECO:0000250|UniProtKB:Q6ZPR5, ECO:0000269|PubMed:16517606, ECO:0000269|PubMed:18505924, ECO:0000269|PubMed:25180167, ECO:0000269|PubMed:31495489}.		cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; endoplasmic reticulum organization [GO:0007029]; glycerophospholipid catabolic process [GO:0046475]; sphingomyelin catabolic process [GO:0006685]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nuclear outer membrane [GO:0005640]; sarcolemma [GO:0042383]; trans-Golgi network [GO:0005802]	metal ion binding [GO:0046872]; sphingomyelin phosphodiesterase activity [GO:0004767]; sphingomyelin phosphodiesterase D activity [GO:0050290]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nuclear outer membrane [GO:0005640]; sarcolemma [GO:0042383]; trans-Golgi network [GO:0005802]; metal ion binding [GO:0046872]; sphingomyelin phosphodiesterase activity [GO:0004767]; sphingomyelin phosphodiesterase D activity [GO:0050290]; cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; endoplasmic reticulum organization [GO:0007029]; glycerophospholipid catabolic process [GO:0046475]; sphingomyelin catabolic process [GO:0006685]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16517606, ECO:0000269|PubMed:18505924, ECO:0000269|PubMed:31495489}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:16517606}; Single-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:31495489}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q6ZPR5}.
Q9NXE8	reviewed	CWC25_HUMAN	Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing protein 49) (Spliceosome-associated protein homolog CWC25)	CWC25 CCDC49	Homo sapiens (Human)	425	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome. {ECO:0000269|PubMed:29301961}.		mRNA splicing, via spliceosome [GO:0000398]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type spliceosomal complex [GO:0005684]		nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type spliceosomal complex [GO:0005684]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29301961}.
Q9NXF8	reviewed	ZDHC7_HUMAN	Palmitoyltransferase ZDHHC7 (EC 2.3.1.225) (Acyltransferase ZDHHC7) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 7) (DHHC-7)	ZDHHC7	Homo sapiens (Human)	308	FUNCTION: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:22031296, PubMed:27380321, PubMed:28196865). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095). Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane (PubMed:25301068). In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation (PubMed:27380321). Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (PubMed:28196865). Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity). In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity). {ECO:0000250|UniProtKB:Q91WU6, ECO:0000250|UniProtKB:Q923G5, ECO:0000269|PubMed:19001095, ECO:0000269|PubMed:22031296, ECO:0000269|PubMed:25301068, ECO:0000269|PubMed:27380321, ECO:0000269|PubMed:28196865}.		androgen receptor signaling pathway [GO:0030521]; glucose import in response to insulin stimulus [GO:0044381]; negative regulation of catabolic process [GO:0009895]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; polarized epithelial cell differentiation [GO:0030859]; progesterone receptor signaling pathway [GO:0050847]; protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; regulation of Fas signaling pathway [GO:1902044]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of protein localization to cell-cell junction [GO:0150106]; regulation of protein localization to plasma membrane [GO:1903076]; steroid hormone mediated signaling pathway [GO:0043401]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; androgen receptor signaling pathway [GO:0030521]; glucose import in response to insulin stimulus [GO:0044381]; negative regulation of catabolic process [GO:0009895]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; polarized epithelial cell differentiation [GO:0030859]; progesterone receptor signaling pathway [GO:0050847]; protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; regulation of Fas signaling pathway [GO:1902044]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of protein localization to cell-cell junction [GO:0150106]; regulation of protein localization to plasma membrane [GO:1903076]; steroid hormone mediated signaling pathway [GO:0043401]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:22031296}; Multi-pass membrane protein {ECO:0000255}.
Q9NXG0	reviewed	CNTLN_HUMAN	Centlein (Centrosomal protein)	CNTLN C9orf101 C9orf39	Homo sapiens (Human)	1405	FUNCTION: Required for centrosome cohesion and recruitment of CEP68 to centrosomes. {ECO:0000269|PubMed:24554434}.		centriole-centriole cohesion [GO:0010457]; protein localization to organelle [GO:0033365]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; centriole-centriole cohesion [GO:0010457]; protein localization to organelle [GO:0033365]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:24554434}. Note=Colocalizes with gamma-tubulin during interphase and mitosis. Appears to associate with the mother centriole during G1 phase and with daughter centrioles towards G1/S phase (By similarity). Localizes to the proximal ends of the centrioles (PubMed:24554434). Levels are high at interphase centrosomes but are reduced on mitotic spindle poles (PubMed:24554434). {ECO:0000250|UniProtKB:A9ZSY0, ECO:0000269|PubMed:24554434}.
Q9NXG2	reviewed	THUM1_HUMAN	THUMP domain-containing protein 1	THUMPD1	Homo sapiens (Human)	353	FUNCTION: Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C) (PubMed:25653167, PubMed:35196516). {ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:35196516}.		tRNA modification [GO:0006400]	nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; tRNA modification [GO:0006400]	
Q9NXG6	reviewed	P4HTM_HUMAN	Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4)	P4HTM PH4	Homo sapiens (Human)	502	FUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. {ECO:0000269|PubMed:17726031}.		regulation of erythrocyte differentiation [GO:0045646]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656]; regulation of erythrocyte differentiation [GO:0045646]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}; Single-pass type II membrane protein {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}.
Q9NXH9	reviewed	TRM1_HUMAN	tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase)	TRMT1	Homo sapiens (Human)	659	FUNCTION: Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.		tRNA modification [GO:0006400]; tRNA N2-guanine methylation [GO:0002940]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA (guanine-N2-)-methyltransferase activity [GO:0004809]; tRNA binding [GO:0000049]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA (guanine-N2-)-methyltransferase activity [GO:0004809]; tRNA binding [GO:0000049]; tRNA modification [GO:0006400]; tRNA N2-guanine methylation [GO:0002940]	
Q9NXI6	reviewed	RN186_HUMAN	E3 ubiquitin-protein ligase RNF186 (EC 2.3.2.27) (RING finger protein 186)	RNF186	Homo sapiens (Human)	227	FUNCTION: E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress (PubMed:23896122). Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis (PubMed:23896122). Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens. Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR (PubMed:34623328). Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2 and EPHB3. Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction (PubMed:33280498). Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity (PubMed:31586034). {ECO:0000269|PubMed:23896122, ECO:0000269|PubMed:31586034, ECO:0000269|PubMed:33280498, ECO:0000269|PubMed:34623328}.		intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K29-linked ubiquitination [GO:0035519]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; regulation of autophagosome assembly [GO:2000785]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K29-linked ubiquitination [GO:0035519]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; regulation of autophagosome assembly [GO:2000785]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23896122, ECO:0000269|PubMed:34623328}; Multi-pass membrane protein {ECO:0000255}.
Q9NXJ5	reviewed	PGPI_HUMAN	Pyroglutamyl-peptidase 1 (EC 3.4.19.3) (5-oxoprolyl-peptidase) (Pyroglutamyl aminopeptidase I) (PAP-I) (Pyroglutamyl-peptidase I) (PGP-I) (Pyrrolidone-carboxylate peptidase)	PGPEP1 PGPI	Homo sapiens (Human)	209	FUNCTION: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. {ECO:0000269|PubMed:12651114}.		protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	cytosol [GO:0005829]	pyroglutamyl-peptidase activity [GO:0016920]	cytosol [GO:0005829]; pyroglutamyl-peptidase activity [GO:0016920]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9NXL9	reviewed	MCM9_HUMAN	DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9)	MCM9 C6orf61 MCMDC1	Homo sapiens (Human)	1143	FUNCTION: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}.	MISCELLANEOUS: [Isoform L]: Most abundant isoform.	DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; double-strand break repair via homologous recombination [GO:0000724]; female gamete generation [GO:0007292]; mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication [GO:0070716]; protein localization to chromatin [GO:0071168]; recombinational interstrand cross-link repair [GO:0036298]	chromosome [GO:0005694]; MCM complex [GO:0042555]; MCM8-MCM9 complex [GO:0097362]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA helicase activity [GO:0003678]; enzyme binding [GO:0019899]; MutLbeta complex binding [GO:0032406]; MutSalpha complex binding [GO:0032407]; MutSbeta complex binding [GO:0032408]; protein-containing complex binding [GO:0044877]; single-stranded DNA binding [GO:0003697]	chromosome [GO:0005694]; MCM complex [GO:0042555]; MCM8-MCM9 complex [GO:0097362]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA helicase activity [GO:0003678]; enzyme binding [GO:0019899]; MutLbeta complex binding [GO:0032406]; MutSalpha complex binding [GO:0032407]; MutSbeta complex binding [GO:0032408]; protein-containing complex binding [GO:0044877]; single-stranded DNA binding [GO:0003697]; DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; double-strand break repair via homologous recombination [GO:0000724]; female gamete generation [GO:0007292]; mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication [GO:0070716]; protein localization to chromatin [GO:0071168]; recombinational interstrand cross-link repair [GO:0036298]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26300262}. Chromosome {ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26300262}. Note=Colocalizes to nuclear foci with RPA1 following DNA damage (PubMed:23401855). Localizes to double-stranded DNA breaks (PubMed:23401855). Recruited to chromatin by MSH2 (PubMed:26300262). {ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26300262}.
Q9NXR1	reviewed	NDE1_HUMAN	Nuclear distribution protein nudE homolog 1 (NudE)	NDE1 NUDE	Homo sapiens (Human)	335	FUNCTION: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752}.		cell division [GO:0051301]; cell migration [GO:0016477]; centrosome duplication [GO:0051298]; centrosome localization [GO:0051642]; cerebral cortex development [GO:0021987]; chromosome segregation [GO:0007059]; establishment of chromosome localization [GO:0051303]; establishment of mitotic spindle orientation [GO:0000132]; microtubule nucleation [GO:0007020]; mitotic centrosome separation [GO:0007100]; neuroblast proliferation [GO:0007405]; neuron migration [GO:0001764]; vesicle transport along microtubule [GO:0047496]	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; spindle pole centrosome [GO:0031616]; synapse [GO:0045202]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; spindle pole centrosome [GO:0031616]; synapse [GO:0045202]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; cell division [GO:0051301]; cell migration [GO:0016477]; centrosome duplication [GO:0051298]; centrosome localization [GO:0051642]; cerebral cortex development [GO:0021987]; chromosome segregation [GO:0007059]; establishment of chromosome localization [GO:0051303]; establishment of mitotic spindle orientation [GO:0000132]; microtubule nucleation [GO:0007020]; mitotic centrosome separation [GO:0007100]; neuroblast proliferation [GO:0007405]; neuron migration [GO:0001764]; vesicle transport along microtubule [GO:0047496]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis.
Q9NXR5	reviewed	ANR10_HUMAN	Ankyrin repeat domain-containing protein 10	ANKRD10	Homo sapiens (Human)	420				nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	
Q9NXR7	reviewed	BABA2_HUMAN	BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein)	BABAM2 BRCC45 BRE	Homo sapiens (Human)	383	FUNCTION: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831). {ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26195665, ECO:0000305|PubMed:15465831}.		apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA repair [GO:0045739]; protein K63-linked deubiquitination [GO:0070536]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]; signal transduction [GO:0007165]	BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	peroxisome targeting sequence binding [GO:0000268]; polyubiquitin modification-dependent protein binding [GO:0031593]; tumor necrosis factor receptor binding [GO:0005164]	BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisome targeting sequence binding [GO:0000268]; polyubiquitin modification-dependent protein binding [GO:0031593]; tumor necrosis factor receptor binding [GO:0005164]; apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA repair [GO:0045739]; protein K63-linked deubiquitination [GO:0070536]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15465831, ECO:0000269|PubMed:24075985}. Nucleus {ECO:0000269|PubMed:15465831, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:24075985}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000269|PubMed:19261748}.
Q9NXR8	reviewed	ING3_HUMAN	Inhibitor of growth protein 3 (p47ING3)	ING3 HSPC301	Homo sapiens (Human)	418	FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:12545155, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]	NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Piccolo NuA4 histone acetyltransferase complex [GO:0032777]; Swr1 complex [GO:0000812]	histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]	NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Piccolo NuA4 histone acetyltransferase complex [GO:0032777]; Swr1 complex [GO:0000812]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]	SUBCELLULAR LOCATION: Nucleus.
Q9NXS2	reviewed	QPCTL_HUMAN	Glutaminyl-peptide cyclotransferase-like protein (EC 2.3.2.5) (Golgi-resident glutaminyl-peptide cyclotransferase) (isoQC) (gQC)	QPCTL	Homo sapiens (Human)	382	FUNCTION: Responsible for the biosynthesis of pyroglutamyl peptides. {ECO:0000269|PubMed:18486145, ECO:0000269|PubMed:21288892}.		peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase [GO:0017186]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	glutaminyl-peptide cyclotransferase activity [GO:0016603]; zinc ion binding [GO:0008270]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; glutaminyl-peptide cyclotransferase activity [GO:0016603]; zinc ion binding [GO:0008270]; peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase [GO:0017186]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:18486145}; Single-pass type I membrane protein {ECO:0000269|PubMed:18486145}.
Q9NXV2	reviewed	KCTD5_HUMAN	BTB/POZ domain-containing protein KCTD5	KCTD5	Homo sapiens (Human)	234	FUNCTION: Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (PubMed:18573101). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (PubMed:19361449). {ECO:0000269|PubMed:18573101, ECO:0000269|PubMed:19361449}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17239418}. Cytoplasm {ECO:0000269|PubMed:18573101}. Nucleus. Note=Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins. {ECO:0000269|PubMed:18573101}.
Q9NXV6	reviewed	CARF_HUMAN	CDKN2A-interacting protein (Collaborator of ARF)	CDKN2AIP CARF	Homo sapiens (Human)	580	FUNCTION: Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. {ECO:0000269|PubMed:15109303, ECO:0000269|PubMed:24825908}.		DNA damage response [GO:0006974]; negative regulation of cell growth [GO:0030308]; positive regulation of cell growth [GO:0030307]; positive regulation of signal transduction [GO:0009967]; regulation of protein stability [GO:0031647]	granular component [GO:0001652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	p53 binding [GO:0002039]; RNA binding [GO:0003723]	granular component [GO:0001652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; DNA damage response [GO:0006974]; negative regulation of cell growth [GO:0030308]; positive regulation of cell growth [GO:0030307]; positive regulation of signal transduction [GO:0009967]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:12154087, ECO:0000269|PubMed:12581788}.
Q9NXW2	reviewed	DJB12_HUMAN	DnaJ homolog subfamily B member 12	DNAJB12	Homo sapiens (Human)	375	FUNCTION: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21150129, PubMed:21148293). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:21148293). Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}.		cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]; ERAD pathway [GO:0036503]; protein-containing complex assembly [GO:0065003]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]	Hsp70 protein binding [GO:0030544]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; Hsp70 protein binding [GO:0030544]; cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]; ERAD pathway [GO:0036503]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:24732912}; Single-pass membrane protein {ECO:0000305}. Note=Localizes to the endoplasmic reticulum membrane (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661). When overexpressed, forms membranous structures in the nucleus (PubMed:24732912). {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; SUBCELLULAR LOCATION: Note=(Microbial infection) Upon SV40 infection, colocalizes with BCAP31, DNAJC18 and DNAJB14 in punctate structures within the endoplasmic reticulum membrane. {ECO:0000269|PubMed:25631089}.
Q9NXW9	reviewed	ALKB4_HUMAN	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-)	ALKBH4 ABH4	Homo sapiens (Human)	302	FUNCTION: Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity). {ECO:0000250|UniProtKB:Q9D8F1, ECO:0000269|PubMed:23673617}.	MISCELLANEOUS: Actin demethylase activity has not been directly confirmed in vitro; however a number of experiments strongly suggest that ALKBH4 acts as a protein demethylase. {ECO:0000305|PubMed:23673617}.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	actomyosin structure organization [GO:0031032]; chromatin organization [GO:0006325]; cleavage furrow ingression [GO:0036090]; DNA demethylation [GO:0080111]; protein demethylation [GO:0006482]; regulation of chromatin organization [GO:1902275]	contractile ring [GO:0070938]; cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleolus [GO:0005730]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; actin binding [GO:0003779]; demethylase activity [GO:0032451]; metal ion binding [GO:0046872]; oxidative DNA demethylase activity [GO:0035516]; oxidoreductase activity [GO:0016491]	contractile ring [GO:0070938]; cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleolus [GO:0005730]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; actin binding [GO:0003779]; demethylase activity [GO:0032451]; metal ion binding [GO:0046872]; oxidative DNA demethylase activity [GO:0035516]; oxidoreductase activity [GO:0016491]; actomyosin structure organization [GO:0031032]; chromatin organization [GO:0006325]; cleavage furrow ingression [GO:0036090]; DNA demethylation [GO:0080111]; protein demethylation [GO:0006482]; regulation of chromatin organization [GO:1902275]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17979886}. Nucleus {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:23145062}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9D8F1}. Midbody {ECO:0000269|PubMed:23673617}. Note=Associates with the contractile ring and midbody. {ECO:0000269|PubMed:23673617}.
Q9NXX6	reviewed	NSE4A_HUMAN	Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A)	NSMCE4A C10orf86 PP4762	Homo sapiens (Human)	385	FUNCTION: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888}.		chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]		chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]; chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000305|PubMed:18086888}.
Q9NY12	reviewed	GAR1_HUMAN	H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1)	GAR1 NOLA1	Homo sapiens (Human)	217	FUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:10757788, ECO:0000269|PubMed:15044956}.		snoRNA guided rRNA pseudouridine synthesis [GO:0000454]; telomere maintenance via telomerase [GO:0007004]	box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; chromosome, telomeric region [GO:0000781]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; telomerase holoenzyme complex [GO:0005697]	box H/ACA snoRNA binding [GO:0034513]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; chromosome, telomeric region [GO:0000781]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; telomerase holoenzyme complex [GO:0005697]; box H/ACA snoRNA binding [GO:0034513]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; snoRNA guided rRNA pseudouridine synthesis [GO:0000454]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
Q9NY15	reviewed	STAB1_HUMAN	Stabilin-1 (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1) (FEEL-1) (MS-1 antigen)	STAB1 FEEL1 KIAA0246	Homo sapiens (Human)	2570	FUNCTION: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. {ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:16357325}.		cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; defense response to bacterium [GO:0042742]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; receptor-mediated endocytosis [GO:0006898]	endocytic vesicle membrane [GO:0030666]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-disulfide reductase activity [GO:0015035]; scavenger receptor activity [GO:0005044]	endocytic vesicle membrane [GO:0030666]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-disulfide reductase activity [GO:0015035]; scavenger receptor activity [GO:0005044]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; defense response to bacterium [GO:0042742]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9NY25	reviewed	CLC5A_HUMAN	C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1)	CLEC5A CLECSF5 MDL1	Homo sapiens (Human)	188	FUNCTION: Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP (PubMed:10449773). Regulates inflammatory responses (By similarity). {ECO:0000250|UniProtKB:Q9R007, ECO:0000269|PubMed:10449773}.; FUNCTION: (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4 (PubMed:18496526, PubMed:21566123). The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP (PubMed:18496526). This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release (PubMed:18496526). {ECO:0000269|PubMed:18496526, ECO:0000269|PubMed:21566123}.	MISCELLANEOUS: Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation when its activation leads to enhanced recruitment of inflammatory macrophages and neutrophils to the joints. {ECO:0000250|UniProtKB:Q9R007}.	cellular defense response [GO:0006968]; innate immune response [GO:0045087]; myeloid cell differentiation [GO:0030099]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myeloid cell apoptotic process [GO:0033033]; osteoblast development [GO:0002076]; positive regulation of cytokine production [GO:0001819]; signal transduction [GO:0007165]	cell surface [GO:0009986]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	carbohydrate binding [GO:0030246]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; carbohydrate binding [GO:0030246]; virus receptor activity [GO:0001618]; cellular defense response [GO:0006968]; innate immune response [GO:0045087]; myeloid cell differentiation [GO:0030099]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myeloid cell apoptotic process [GO:0033033]; osteoblast development [GO:0002076]; positive regulation of cytokine production [GO:0001819]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21566123}; Single-pass type II membrane protein {ECO:0000269|PubMed:21566123}.
Q9NY26	reviewed	S39A1_HUMAN	Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1)	SLC39A1 IRT1 ZIP1 ZIRTL CGI-08 CGI-71	Homo sapiens (Human)	324	FUNCTION: Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:11301334, PubMed:12888280, PubMed:16844077). Functions as the major importer of zinc from circulating blood plasma into prostate cells (PubMed:12888280). {ECO:0000269|PubMed:11301334, ECO:0000269|PubMed:12888280, ECO:0000269|PubMed:16844077}.	MISCELLANEOUS: Inhibited by Ni(2+) ions. Fe(2+) ions do not inhibit zinc uptake.	embryonic cranial skeleton morphogenesis [GO:0048701]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; monoatomic cation transport [GO:0006812]; zinc ion transmembrane transport [GO:0071577]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	inorganic cation transmembrane transporter activity [GO:0022890]; signaling receptor binding [GO:0005102]; zinc ion transmembrane transporter activity [GO:0005385]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; inorganic cation transmembrane transporter activity [GO:0022890]; signaling receptor binding [GO:0005102]; zinc ion transmembrane transporter activity [GO:0005385]; embryonic cranial skeleton morphogenesis [GO:0048701]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; monoatomic cation transport [GO:0006812]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11301334, ECO:0000269|PubMed:11696349, ECO:0000269|PubMed:16844077}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11696349}; Multi-pass membrane protein {ECO:0000255}. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines. {ECO:0000269|PubMed:11696349}.
Q9NY27	reviewed	PP4R2_HUMAN	Serine/threonine-protein phosphatase 4 regulatory subunit 2	PPP4R2 SBBI57	Homo sapiens (Human)	417	FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}.		mRNA processing [GO:0006397]; protein modification process [GO:0036211]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via homologous recombination [GO:0010569]; RNA splicing [GO:0008380]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase 4 complex [GO:0030289]	protein phosphatase regulator activity [GO:0019888]; protein-macromolecule adaptor activity [GO:0030674]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase 4 complex [GO:0030289]; protein phosphatase regulator activity [GO:0019888]; protein-macromolecule adaptor activity [GO:0030674]; mRNA processing [GO:0006397]; protein modification process [GO:0036211]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via homologous recombination [GO:0010569]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.
Q9NY28	reviewed	GALT8_HUMAN	Probable polypeptide N-acetylgalactosaminyltransferase 8 (EC 2.4.1.41) (Polypeptide GalNAc transferase 8) (GalNAc-T8) (pp-GaNTase 8) (Protein-UDP acetylgalactosaminyltransferase 8) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 8)	GALNT8	Homo sapiens (Human)	637	FUNCTION: Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. {ECO:0000250|UniProtKB:Q9HCQ5}.		O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9HCQ5}; Single-pass type II membrane protein {ECO:0000255}.
Q9NY30	reviewed	BTG4_HUMAN	Protein BTG4 (BTG family member 4) (Protein PC3b)	BTG4 PC3B	Homo sapiens (Human)	223	FUNCTION: Adapter protein that bridges CNOT7, a catalytic subunit of the CCR4-NOT complex, to EIF4E (By similarity). Facilitates maternal mRNAs decay during the maturation of oocytes and in the fertilized egg, and is required for the maternal-zygotic transition (MZT), zygotic cleavage and initiation of embryonic development (PubMed:32502391). {ECO:0000250|UniProtKB:O70552, ECO:0000269|PubMed:32502391}.		negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930]; neuron differentiation [GO:0030182]; regulation of cell cycle [GO:0051726]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930]; neuron differentiation [GO:0030182]; regulation of cell cycle [GO:0051726]	
Q9NY33	reviewed	DPP3_HUMAN	Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B)	DPP3	Homo sapiens (Human)	737	FUNCTION: Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; metalloexopeptidase activity [GO:0008235]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; metalloexopeptidase activity [GO:0008235]; zinc ion binding [GO:0008270]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187}.
Q9NY46	reviewed	SCN3A_HUMAN	Sodium channel protein type 3 subunit alpha (Sodium channel protein brain III subunit alpha) (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subtype III) (Voltage-gated sodium channel subunit alpha Nav1.3)	SCN3A KIAA1356 NAC3	Homo sapiens (Human)	2000	FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:24157691, PubMed:28235671, PubMed:29466837). May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (By similarity). In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (By similarity). {ECO:0000250|UniProtKB:A2ASI5, ECO:0000269|PubMed:24157691, ECO:0000269|PubMed:28235671, ECO:0000269|PubMed:29466837}.		behavioral response to pain [GO:0048266]; calcium ion import across plasma membrane [GO:0098703]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transport [GO:0006814]	sarcoplasm [GO:0016528]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]	high voltage-gated calcium channel activity [GO:0008331]; voltage-gated sodium channel activity [GO:0005248]	sarcoplasm [GO:0016528]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated sodium channel activity [GO:0005248]; behavioral response to pain [GO:0048266]; calcium ion import across plasma membrane [GO:0098703]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28235671}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}.
Q9NY47	reviewed	CA2D2_HUMAN	Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]	CACNA2D2 KIAA0558	Homo sapiens (Human)	1150	FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G) (PubMed:15111129, PubMed:23339110). Overexpression induces apoptosis. {ECO:0000269|PubMed:12555074, ECO:0000269|PubMed:15111129, ECO:0000269|PubMed:23339110}.	MISCELLANEOUS: Binds gabapentin, an antiepileptic drug.	regulation of monoatomic ion transmembrane transport [GO:0034765]	plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]	metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]	plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with CACNA1A in lipid raft fractions. {ECO:0000250}.
Q9NY56	reviewed	OBP2A_HUMAN	Odorant-binding protein 2a (Odorant-binding protein IIa) (OBPIIa)	OBP2A	Homo sapiens (Human)	170	FUNCTION: Binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids, including undecanal, palmitic acid, efficient aldehydes, benzenic aldehydes, heterocyclic aldehydes and aliphatic acids. {ECO:0000269|PubMed:12044155, ECO:0000269|PubMed:16546182}.		glucose homeostasis [GO:0042593]; response to stimulus [GO:0050896]; sensory perception of chemical stimulus [GO:0007606]; sensory perception of smell [GO:0007608]	extracellular space [GO:0005615]	odorant binding [GO:0005549]; small molecule binding [GO:0036094]	extracellular space [GO:0005615]; odorant binding [GO:0005549]; small molecule binding [GO:0036094]; glucose homeostasis [GO:0042593]; response to stimulus [GO:0050896]; sensory perception of chemical stimulus [GO:0007606]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9NY59	reviewed	NSMA2_HUMAN	Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II)	SMPD3	Homo sapiens (Human)	655	FUNCTION: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}.		BMP signaling pathway [GO:0030509]; bone growth [GO:0098868]; bone mineralization [GO:0030282]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to magnesium ion [GO:0071286]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to peptide [GO:1901653]; cellular response to redox state [GO:0071461]; cellular response to tumor necrosis factor [GO:0071356]; ceramide metabolic process [GO:0006672]; chondrocyte development involved in endochondral bone morphogenesis [GO:0003433]; collagen metabolic process [GO:0032963]; dentinogenesis [GO:0097187]; DNA biosynthetic process [GO:0071897]; endochondral ossification [GO:0001958]; extracellular matrix assembly [GO:0085029]; G1 to G0 transition [GO:0070314]; hematopoietic progenitor cell differentiation [GO:0002244]; lung alveolus development [GO:0048286]; mitotic nuclear division [GO:0140014]; multicellular organism growth [GO:0035264]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; peptide hormone secretion [GO:0030072]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; polysaccharide transport [GO:0015774]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of cartilage development [GO:0061035]; regulation of leukocyte migration [GO:0002685]; regulation of protein phosphorylation [GO:0001932]; sphingolipid mediated signaling pathway [GO:0090520]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; neutral sphingomyelin phosphodiesterase activity [GO:0061751]; phosphatidic acid binding [GO:0070300]; phosphatidylserine binding [GO:0001786]; phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; neutral sphingomyelin phosphodiesterase activity [GO:0061751]; phosphatidic acid binding [GO:0070300]; phosphatidylserine binding [GO:0001786]; phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767]; BMP signaling pathway [GO:0030509]; bone growth [GO:0098868]; bone mineralization [GO:0030282]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to magnesium ion [GO:0071286]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to peptide [GO:1901653]; cellular response to redox state [GO:0071461]; cellular response to tumor necrosis factor [GO:0071356]; ceramide metabolic process [GO:0006672]; chondrocyte development involved in endochondral bone morphogenesis [GO:0003433]; collagen metabolic process [GO:0032963]; dentinogenesis [GO:0097187]; DNA biosynthetic process [GO:0071897]; endochondral ossification [GO:0001958]; extracellular matrix assembly [GO:0085029]; G1 to G0 transition [GO:0070314]; hematopoietic progenitor cell differentiation [GO:0002244]; lung alveolus development [GO:0048286]; mitotic nuclear division [GO:0140014]; multicellular organism growth [GO:0035264]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; peptide hormone secretion [GO:0030072]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; polysaccharide transport [GO:0015774]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of cartilage development [GO:0061035]; regulation of leukocyte migration [GO:0002685]; regulation of protein phosphorylation [GO:0001932]; sphingolipid mediated signaling pathway [GO:0090520]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:10823942}; Lipid-anchor {ECO:0000269|PubMed:10823942}. Cell membrane {ECO:0000269|PubMed:15051724}; Lipid-anchor {ECO:0000269|PubMed:15051724}. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons (PubMed:10823942). Localizes to plasma membrane in confluent contact-inhaibited cells (PubMed:15051724).
Q9NY61	reviewed	AATF_HUMAN	Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1)	AATF CHE1 DED HSPC277	Homo sapiens (Human)	560	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}.		cell adhesion [GO:0007155]; DNA damage response [GO:0006974]; embryonic cleavage [GO:0040016]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of superoxide anion generation [GO:0032929]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]; ribosomal small subunit biogenesis [GO:0042274]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; transcription regulator complex [GO:0005667]	leucine zipper domain binding [GO:0043522]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; transcription regulator complex [GO:0005667]; leucine zipper domain binding [GO:0043522]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]; cell adhesion [GO:0007155]; DNA damage response [GO:0006974]; embryonic cleavage [GO:0040016]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of superoxide anion generation [GO:0032929]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:34516797}.
Q9NY64	reviewed	SL2A8_HUMAN	Solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8) (Glucose transporter type X1)	SLC2A8 GLUT8 GLUTX1	Homo sapiens (Human)	477	FUNCTION: Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1 (PubMed:27922102). Also able to mediate the transport of dehydroascorbate. {ECO:0000250|UniProtKB:Q9JIF3, ECO:0000269|PubMed:27922102}.		carbohydrate metabolic process [GO:0005975]; dehydroascorbic acid transport [GO:0070837]; fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; insulin receptor signaling pathway [GO:0008286]; response to hypoxia [GO:0001666]	clathrin-coated endocytic vesicle membrane [GO:0030669]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; fructose transmembrane transporter activity [GO:0005353]; glucose binding [GO:0005536]; glucose transmembrane transporter activity [GO:0005355]	clathrin-coated endocytic vesicle membrane [GO:0030669]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; fructose transmembrane transporter activity [GO:0005353]; glucose binding [GO:0005536]; glucose transmembrane transporter activity [GO:0005355]; carbohydrate metabolic process [GO:0005975]; dehydroascorbic acid transport [GO:0070837]; fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; insulin receptor signaling pathway [GO:0008286]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9JJZ1}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9JJZ1}; Multi-pass membrane protein {ECO:0000255}. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration. {ECO:0000250|UniProtKB:Q9JJZ1}.
Q9NY65	reviewed	TBA8_HUMAN	Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain]	TUBA8 TUBAL2	Homo sapiens (Human)	449	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.	MISCELLANEOUS: This tubulin does not have a C-terminal tyrosine; however, its C-terminal phenylalanine residue can be cleaved. {ECO:0000269|PubMed:35482892}.	microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; spermatid development [GO:0007286]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
Q9NY72	reviewed	SCN3B_HUMAN	Sodium channel subunit beta-3	SCN3B KIAA1158	Homo sapiens (Human)	215	FUNCTION: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). {ECO:0000250}.		atrial cardiac muscle cell action potential [GO:0086014]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; membrane depolarization [GO:0051899]; membrane depolarization during action potential [GO:0086010]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; nervous system development [GO:0007399]; positive regulation of heart rate [GO:0010460]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; SA node cell action potential [GO:0086015]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; ventricular cardiac muscle cell action potential [GO:0086005]	membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018]	sodium channel inhibitor activity [GO:0019871]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]	membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018]; sodium channel inhibitor activity [GO:0019871]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]; atrial cardiac muscle cell action potential [GO:0086014]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; membrane depolarization [GO:0051899]; membrane depolarization during action potential [GO:0086010]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; nervous system development [GO:0007399]; positive regulation of heart rate [GO:0010460]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; SA node cell action potential [GO:0086015]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9NY74	reviewed	ETAA1_HUMAN	Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16)	ETAA1 ETAA16	Homo sapiens (Human)	926	FUNCTION: Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723720, PubMed:27723717). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723720, PubMed:27723717). Probably only regulates a subset of ATR targets (PubMed:27723720, PubMed:27723717). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of DNA damage checkpoint [GO:2000001]; replication fork processing [GO:0031297]	cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]	protein serine/threonine kinase activator activity [GO:0043539]	cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; protein serine/threonine kinase activator activity [GO:0043539]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of DNA damage checkpoint [GO:2000001]; replication fork processing [GO:0031297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720}. Note=Localizes at sites of DNA damage following replication stress (PubMed:27601467, PubMed:27723720, PubMed:27723717). Recruited to stalled replication forks via interaction with RPA1 and RPA2 subunits of the RPA complex (PubMed:27601467, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720}.
Q9NY91	reviewed	SC5A4_HUMAN	Probable glucose sensor protein SLC5A4 (Solute carrier family 5 member 4)	SLC5A4 SAAT1 SGLT3	Homo sapiens (Human)	659	FUNCTION: Does not function as sodium/D-glucose symporter (PubMed:13130073, PubMed:20421923, PubMed:22766068). However, may function as a D-glucose sensor by generating a D-glucose-induced depolarization which is pH-independent, Na(+)-dependent at neutral pH and probably H(+)-dependent at acidic pH (PubMed:13130073, PubMed:22766068, PubMed:17110502, PubMed:20421923). {ECO:0000269|PubMed:13130073, ECO:0000269|PubMed:17110502, ECO:0000269|PubMed:20421923, ECO:0000269|PubMed:22766068}.	MISCELLANEOUS: Although it belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family, lacks Na(+)/glucose symporter activity. {ECO:0000305|PubMed:13130073}.	sodium ion transport [GO:0006814]	plasma membrane [GO:0005886]	glucose:sodium symporter activity [GO:0005412]	plasma membrane [GO:0005886]; glucose:sodium symporter activity [GO:0005412]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:13130073, ECO:0000305|PubMed:17110502, ECO:0000305|PubMed:20421923, ECO:0000305|PubMed:22766068}; Multi-pass membrane protein {ECO:0000255}.
Q9NY93	reviewed	DDX56_HUMAN	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.4.13) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD box protein 21) (DEAD box protein 56)	DDX56 DDX21 NOH61	Homo sapiens (Human)	547	FUNCTION: Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization (PubMed:31340999, PubMed:33789112). Plays an essential role in maintaining nucleolar integrity in planarian stem cells (PubMed:33789112). Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (By similarity). Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3 (PubMed:31340999). Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5 (PubMed:31340999). May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity. {ECO:0000250|UniProtKB:Q9D0R4, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:33789112}.; FUNCTION: (Microbial infection) Helicase activity is important for packaging viral RNA into virions during West Nile virus infection. {ECO:0000269|PubMed:22925334}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease virus replication by inhibiting the phosphorylation of IRF3 leading to inhibition of type I interferon. {ECO:0000269|PubMed:31445188}.; FUNCTION: (Microbial infection) Plays a positive role in EMCV replication by interrupting IRF3 phosphorylation and its nucleus translocation. {ECO:0000269|PubMed:34922148}.		defense response to virus [GO:0051607]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation of type I interferon production [GO:0032480]; positive regulation of neuron projection development [GO:0010976]; rRNA processing [GO:0006364]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613]; defense response to virus [GO:0051607]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation of type I interferon production [GO:0032480]; positive regulation of neuron projection development [GO:0010976]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:22925334, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:33789112}.
Q9NY97	reviewed	B3GN2_HUMAN	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (EC 2.4.1.149) (Beta-1,3-N-acetylglucosaminyltransferase 1) (BGnT-1) (Beta-1,3-Gn-T1) (Beta3Gn-T1) (Beta-1,3-galactosyltransferase 7) (Beta-1,3-GalTase 7) (Beta3Gal-T7) (Beta3GalT7) (b3Gal-T7) (Beta-3-Gx-T7) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2) (BGnT-2) (Beta-1,3-Gn-T2) (Beta-1,3-N-acetylglucosaminyltransferase 2) (Beta3Gn-T2) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7)	B3GNT2 B3GALT7 B3GNT1	Homo sapiens (Human)	397	FUNCTION: Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. {ECO:0000269|PubMed:11042166, ECO:0000269|PubMed:25279697, ECO:0000269|PubMed:9892646}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	axon guidance [GO:0007411]; cellular response to leukemia inhibitory factor [GO:1990830]; keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493]; sensory perception of smell [GO:0007608]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity [GO:0008457]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity [GO:0008457]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; axon guidance [GO:0007411]; cellular response to leukemia inhibitory factor [GO:1990830]; keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9NY99	reviewed	SNTG2_HUMAN	Gamma-2-syntrophin (G2SYN) (Syntrophin-5) (SYN5)	SNTG2	Homo sapiens (Human)	539	FUNCTION: Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). {ECO:0000250}.		central nervous system development [GO:0007417]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; syntrophin complex [GO:0016013]	actin binding [GO:0003779]; neuroligin family protein binding [GO:0097109]; PDZ domain binding [GO:0030165]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; syntrophin complex [GO:0016013]; actin binding [GO:0003779]; neuroligin family protein binding [GO:0097109]; PDZ domain binding [GO:0030165]; structural molecule activity [GO:0005198]; central nervous system development [GO:0007417]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane.
Q9NYA1	reviewed	SPHK1_HUMAN	Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91) (Acetyltransferase SPHK1) (EC 2.3.1.-)	SPHK1 SK1 SPHK SPK	Homo sapiens (Human)	384	FUNCTION: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (PubMed:20577214, PubMed:23602659, PubMed:29662056, PubMed:24929359, PubMed:11923095). In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis (PubMed:16118219). Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion (PubMed:20577214). In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway (PubMed:23935096). Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity (PubMed:28049734, PubMed:24929359). In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA (PubMed:25417698). {ECO:0000269|PubMed:11923095, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:23602659, ECO:0000269|PubMed:23935096, ECO:0000269|PubMed:24929359, ECO:0000269|PubMed:25417698, ECO:0000269|PubMed:28049734, ECO:0000269|PubMed:29662056}.; FUNCTION: Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia. {ECO:0000250|UniProtKB:Q8CI15}.		blood vessel development [GO:0001568]; brain development [GO:0007420]; calcium-mediated signaling [GO:0019722]; cell population proliferation [GO:0008283]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; DNA biosynthetic process [GO:0071897]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ceramide biosynthetic process [GO:1900060]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of smooth muscle contraction [GO:0045987]; protein acetylation [GO:0006473]; regulation of endocytosis [GO:0030100]; regulation of endosomal vesicle fusion [GO:1905364]; regulation of interleukin-1 beta production [GO:0032651]; regulation of microglial cell activation [GO:1903978]; regulation of neuroinflammatory response [GO:0150077]; regulation of phagocytosis [GO:0050764]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to tumor necrosis factor [GO:0034612]; sphingoid catabolic process [GO:0046521]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670]	clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	acetyltransferase activity [GO:0016407]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; D-erythro-sphingosine kinase activity [GO:0017050]; DNA binding [GO:0003677]; lipid binding [GO:0008289]; magnesium ion binding [GO:0000287]; protein phosphatase 2A binding [GO:0051721]; sphinganine kinase activity [GO:0008481]; sphingosine-1-phosphate receptor activity [GO:0038036]	clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; acetyltransferase activity [GO:0016407]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; D-erythro-sphingosine kinase activity [GO:0017050]; DNA binding [GO:0003677]; lipid binding [GO:0008289]; magnesium ion binding [GO:0000287]; protein phosphatase 2A binding [GO:0051721]; sphinganine kinase activity [GO:0008481]; sphingosine-1-phosphate receptor activity [GO:0038036]; blood vessel development [GO:0001568]; brain development [GO:0007420]; calcium-mediated signaling [GO:0019722]; cell population proliferation [GO:0008283]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; DNA biosynthetic process [GO:0071897]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ceramide biosynthetic process [GO:1900060]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of smooth muscle contraction [GO:0045987]; protein acetylation [GO:0006473]; regulation of endocytosis [GO:0030100]; regulation of endosomal vesicle fusion [GO:1905364]; regulation of interleukin-1 beta production [GO:0032651]; regulation of microglial cell activation [GO:1903978]; regulation of neuroinflammatory response [GO:0150077]; regulation of phagocytosis [GO:0050764]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to tumor necrosis factor [GO:0034612]; sphingoid catabolic process [GO:0046521]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14575709, ECO:0000269|PubMed:19854831, ECO:0000269|PubMed:29662056}. Nucleus {ECO:0000269|PubMed:14575709, ECO:0000269|PubMed:19854831, ECO:0000269|PubMed:29662056}. Cell membrane {ECO:0000269|PubMed:19854831}. Endosome membrane {ECO:0000269|PubMed:24929359}; Peripheral membrane protein {ECO:0000269|PubMed:24929359}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:24929359}. Synapse {ECO:0000250|UniProtKB:Q8CI15}. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner (PubMed:19854831). Binds to membranes containing negatively charged lipids but not neutral lipids (PubMed:24929359). Recruited to endocytic membranes by sphingosine where promotes membrane fusion (By similarity). {ECO:0000250|UniProtKB:Q8CI15, ECO:0000269|PubMed:19854831, ECO:0000269|PubMed:24929359}.
Q9NYA3	reviewed	GOG6A_HUMAN	Golgin subfamily A member 6A (Golgin linked to PML) (Golgin-like protein)	GOLGA6A GLP GOLGA6	Homo sapiens (Human)	693			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
Q9NYA4	reviewed	MTMR4_HUMAN	Myotubularin-related protein 4 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Zinc finger FYVE domain-containing protein 11)	MTMR4 KIAA0647 ZFYVE11	Homo sapiens (Human)	1195	FUNCTION: Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3). {ECO:0000269|PubMed:11302699}.		negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; protein dephosphorylation [GO:0006470]; regulation of autophagy [GO:0010506]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular space [GO:0005615]; membrane [GO:0016020]	metal ion binding [GO:0046872]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular space [GO:0005615]; membrane [GO:0016020]; metal ion binding [GO:0046872]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; protein dephosphorylation [GO:0006470]; regulation of autophagy [GO:0010506]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11302699}. Membrane {ECO:0000269|PubMed:11302699}; Peripheral membrane protein {ECO:0000269|PubMed:11302699}. Note=Localized to perinuclear region.
Q9NYB0	reviewed	TE2IP_HUMAN	Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1)	TERF2IP DRIP5 RAP1 PP8000	Homo sapiens (Human)	399	FUNCTION: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}.	MISCELLANEOUS: Shares a bidirectional promoter with KARS1. {ECO:0000305|PubMed:14659874}.	negative regulation of DNA recombination at telomere [GO:0048239]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of telomere maintenance [GO:0032205]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of telomere maintenance [GO:0032206]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of telomere maintenance [GO:0032204]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomere maintenance via telomere lengthening [GO:0010833]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; shelterin complex [GO:0070187]	G-rich strand telomeric DNA binding [GO:0098505]; phosphatase binding [GO:0019902]; telomeric DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; shelterin complex [GO:0070187]; G-rich strand telomeric DNA binding [GO:0098505]; phosphatase binding [GO:0019902]; telomeric DNA binding [GO:0042162]; negative regulation of DNA recombination at telomere [GO:0048239]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of telomere maintenance [GO:0032205]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of telomere maintenance [GO:0032206]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of telomere maintenance [GO:0032204]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomere maintenance via telomere lengthening [GO:0010833]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91VL8}. Cytoplasm {ECO:0000250|UniProtKB:Q91VL8}. Chromosome {ECO:0000250|UniProtKB:Q91VL8}. Chromosome, telomere {ECO:0000250|UniProtKB:Q91VL8}. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex. {ECO:0000250|UniProtKB:Q91VL8}.
Q9NYB5	reviewed	SO1C1_HUMAN	Solute carrier organic anion transporter family member 1C1 (Organic anion transporter 1C1) (OATP1C1) (Organic anion transporter F) (OATP-F) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATP-RP5) (Organic anion-transporting polypeptide 14) (OATP-14) (Solute carrier family 21 member 14) (Thyroxine transporter)	SLCO1C1 OATP14 OATP1C1 OATPF SLC21A14	Homo sapiens (Human)	712	FUNCTION: Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed:12351693, PubMed:18566113, PubMed:19129463). Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed:18566113). Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed:18566113). Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed:12351693, PubMed:19129463). Transports T4 and E1S in a pH-insensitive manner (PubMed:19129463). Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed:30296914). {ECO:0000269|PubMed:12351693, ECO:0000269|PubMed:18566113, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30296914}.		bile acid and bile salt transport [GO:0015721]; monoatomic ion transport [GO:0006811]; positive regulation of thyroid hormone generation [GO:2000611]; sodium-independent organic anion transport [GO:0043252]; thyroid hormone transport [GO:0070327]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349]; bile acid and bile salt transport [GO:0015721]; monoatomic ion transport [GO:0006811]; positive regulation of thyroid hormone generation [GO:2000611]; sodium-independent organic anion transport [GO:0043252]; thyroid hormone transport [GO:0070327]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12351693, ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000269|PubMed:18687783}. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus. {ECO:0000269|PubMed:18687783}.
Q9NYB9	reviewed	ABI2_HUMAN	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)	ABI2 ARGBPIA	Homo sapiens (Human)	513	FUNCTION: Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}.		actin polymerization or depolymerization [GO:0008154]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; lens fiber cell morphogenesis [GO:0070309]; nervous system development [GO:0007399]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; Rac protein signal transduction [GO:0016601]; regulation of dendritic spine morphogenesis [GO:0061001]; zonula adherens assembly [GO:0045186]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; SCAR complex [GO:0031209]	cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; proline-rich region binding [GO:0070064]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; ubiquitin protein ligase binding [GO:0031625]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; SCAR complex [GO:0031209]; cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; proline-rich region binding [GO:0070064]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; ubiquitin protein ligase binding [GO:0031625]; actin polymerization or depolymerization [GO:0008154]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; lens fiber cell morphogenesis [GO:0070309]; nervous system development [GO:0007399]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; Rac protein signal transduction [GO:0016601]; regulation of dendritic spine morphogenesis [GO:0061001]; zonula adherens assembly [GO:0045186]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11516653, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. Nucleus {ECO:0000269|PubMed:7590236}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell projection, lamellipodium {ECO:0000269|PubMed:11516653, ECO:0000269|PubMed:15572692}. Cell projection, filopodium {ECO:0000269|PubMed:11516653}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15572692}. Cell junction, adherens junction {ECO:0000269|PubMed:15572692}. Note=Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips (PubMed:11516653, PubMed:15572692). Present at nascent adherens junctions, where it clusters adjacent to the tips of F-actin protrusions (PubMed:15572692). {ECO:0000269|PubMed:11516653, ECO:0000269|PubMed:15572692}.
Q9NYC9	reviewed	DYH9_HUMAN	Dynein axonemal heavy chain 9 (Axonemal beta dynein heavy chain 9) (Ciliary dynein heavy chain 9)	DNAH9 DNAH17L DNEL1 KIAA0357	Homo sapiens (Human)	4486	FUNCTION: Force generating protein required for cilia beating in respiratory epithelia (PubMed:30471717, PubMed:30471718). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. {ECO:0000269|PubMed:30471717, ECO:0000269|PubMed:30471718}.		cell projection organization [GO:0030030]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; distal portion of axoneme [GO:0120135]; dynein complex [GO:0030286]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; distal portion of axoneme [GO:0120135]; dynein complex [GO:0030286]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; cell projection organization [GO:0030030]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:30471717, ECO:0000269|PubMed:30471718, ECO:0000269|PubMed:31178125}. Note=Found in the distal portion of ciliary axoneme. {ECO:0000269|PubMed:30471717, ECO:0000269|PubMed:30471718}.
Q9NYD6	reviewed	HXC10_HUMAN	Homeobox protein Hox-C10 (Homeobox protein Hox-3I)	HOXC10 HOX3I	Homo sapiens (Human)	342	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; embryonic limb morphogenesis [GO:0030326]; negative regulation of cold-induced thermogenesis [GO:0120163]; neuromuscular process [GO:0050905]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; spinal cord motor neuron cell fate specification [GO:0021520]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; embryonic limb morphogenesis [GO:0030326]; negative regulation of cold-induced thermogenesis [GO:0120163]; neuromuscular process [GO:0050905]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; spinal cord motor neuron cell fate specification [GO:0021520]	SUBCELLULAR LOCATION: Nucleus.
Q9NYF0	reviewed	DACT1_HUMAN	Dapper homolog 1 (hDPR1) (Dapper antagonist of catenin 1) (Hepatocellular carcinoma novel gene 3 protein)	DACT1 DPR1 HNG3	Homo sapiens (Human)	836	FUNCTION: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. {ECO:0000250, ECO:0000269|PubMed:15580286, ECO:0000269|PubMed:16446366, ECO:0000269|PubMed:17197390, ECO:0000269|PubMed:18936100, ECO:0000269|PubMed:22470507}.		embryonic hindgut morphogenesis [GO:0048619]; negative regulation of beta-catenin-TCF complex assembly [GO:1904864]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; neural tube development [GO:0021915]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of protein stability [GO:0031647]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]	beta-catenin binding [GO:0008013]; delta-catenin binding [GO:0070097]; histone deacetylase binding [GO:0042826]; protein kinase A binding [GO:0051018]; protein kinase C binding [GO:0005080]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]; beta-catenin binding [GO:0008013]; delta-catenin binding [GO:0070097]; histone deacetylase binding [GO:0042826]; protein kinase A binding [GO:0051018]; protein kinase C binding [GO:0005080]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; embryonic hindgut morphogenesis [GO:0048619]; negative regulation of beta-catenin-TCF complex assembly [GO:1904864]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; neural tube development [GO:0021915]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of protein stability [GO:0031647]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Synapse {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence.
Q9NYF8	reviewed	BCLF1_HUMAN	Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1)	BCLAF1 BTF KIAA0164	Homo sapiens (Human)	920	FUNCTION: Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}.		apoptotic process [GO:0006915]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription in response to stress [GO:0043620]	cytoplasm [GO:0005737]; mediator complex [GO:0016592]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712]	cytoplasm [GO:0005737]; mediator complex [GO:0016592]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712]; apoptotic process [GO:0006915]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription in response to stress [GO:0043620]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus speckle {ECO:0000269|PubMed:24100041}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24100041}.
Q9NYG2	reviewed	ZDHC3_HUMAN	Palmitoyltransferase ZDHHC3 (EC 2.3.1.225) (Acyltransferase ZDHHC3) (EC 2.3.1.-) (Protein DHHC1) (Zinc finger DHHC domain-containing protein 3) (DHHC-3)	ZDHHC3 HSD49	Homo sapiens (Human)	299	FUNCTION: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19001095, PubMed:21926431, PubMed:22240897, PubMed:23034182, PubMed:22314500). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (PubMed:22314500). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (PubMed:22240897). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation (By similarity). Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses (By similarity). Palmitoylates NCDN thereby regulating its association with endosome membranes (By similarity). Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor (By similarity). Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth (By similarity). Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes (By similarity). Also constitutively palmitoylates DLG4 (By similarity). May also palmitoylate SNAP25 (By similarity). Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2 (PubMed:26535572). May also palmitoylate LAMTOR1, promoting its localization to lysosomal membranes (PubMed:35893977). {ECO:0000250|UniProtKB:Q8R173, ECO:0000269|PubMed:19001095, ECO:0000269|PubMed:21926431, ECO:0000269|PubMed:22240897, ECO:0000269|PubMed:22314500, ECO:0000269|PubMed:23034182, ECO:0000269|PubMed:26535572, ECO:0000269|PubMed:35893977}.; FUNCTION: May also function as a calcium transporter. {ECO:0000250|UniProtKB:Q8R173}.		lipoprotein localization to membrane [GO:0044873]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; protein localization to membrane [GO:0072657]; protein localization to photoreceptor outer segment [GO:1903546]; protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	palmitoyltransferase activity [GO:0016409]; protein homodimerization activity [GO:0042803]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; palmitoyltransferase activity [GO:0016409]; protein homodimerization activity [GO:0042803]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; lipoprotein localization to membrane [GO:0044873]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; protein localization to membrane [GO:0072657]; protein localization to photoreceptor outer segment [GO:1903546]; protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16647879, ECO:0000269|PubMed:19001095, ECO:0000269|PubMed:21926431, ECO:0000269|PubMed:26535572}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the Golgi cis cisterna. {ECO:0000250|UniProtKB:Q8R173}.
Q9NYG5	reviewed	APC11_HUMAN	Anaphase-promoting complex subunit 11 (APC11) (Cyclosome subunit 11) (Hepatocellular carcinoma-associated RING finger protein)	ANAPC11 HSPC214	Homo sapiens (Human)	84	FUNCTION: Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; ubiquitin-dependent protein catabolic process [GO:0006511]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cullin family protein binding [GO:0097602]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cullin family protein binding [GO:0097602]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11573242}. Nucleus {ECO:0000269|PubMed:11573242}.
Q9NYG8	reviewed	KCNK4_HUMAN	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid-stimulated potassium channel protein) (TRAAK) (Two pore potassium channel KT4.1) (Two pore K(+) channel KT4.1)	KCNK4 TRAAK	Homo sapiens (Human)	393	FUNCTION: Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157, PubMed:30290154). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity). {ECO:0000250|UniProtKB:G3V8V5, ECO:0000250|UniProtKB:O88454, ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157, ECO:0000269|PubMed:30290154}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to alkaline pH [GO:0071469]; cellular response to fatty acid [GO:0071398]; cellular response to mechanical stimulus [GO:0071260]; cellular response to temperature stimulus [GO:0071502]; detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; memory [GO:0007613]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sensory perception of pain [GO:0019233]; sensory perception of temperature stimulus [GO:0050951]; stabilization of membrane potential [GO:0030322]	plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]	identical protein binding [GO:0042802]; mechanosensitived potassium channel activity [GO:0098782]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; temperature-gated cation channel activity [GO:0097604]	plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; identical protein binding [GO:0042802]; mechanosensitived potassium channel activity [GO:0098782]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; temperature-gated cation channel activity [GO:0097604]; cellular response to alkaline pH [GO:0071469]; cellular response to fatty acid [GO:0071398]; cellular response to mechanical stimulus [GO:0071260]; cellular response to temperature stimulus [GO:0071502]; detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; memory [GO:0007613]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sensory perception of pain [GO:0019233]; sensory perception of temperature stimulus [GO:0050951]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157}; Multi-pass membrane protein {ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157}.
Q9NYH9	reviewed	UTP6_HUMAN	U3 small nucleolar RNA-associated protein 6 homolog (Hepatocellular carcinoma-associated antigen 66) (Multiple hat domains protein)	UTP6 C17orf40 HCA66 MHAT	Homo sapiens (Human)	597	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}.		maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]	snoRNA binding [GO:0030515]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]; snoRNA binding [GO:0030515]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:34516797}.
Q9NYI0	reviewed	PSD3_HUMAN	PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3)	PSD3 EFA6D EFA6R HCA67 KIAA0942	Homo sapiens (Human)	1048	FUNCTION: Guanine nucleotide exchange factor for ARF6. {ECO:0000250}.		regulation of ARF protein signal transduction [GO:0032012]	postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587]	guanyl-nucleotide exchange factor activity [GO:0005085]	postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of ARF protein signal transduction [GO:0032012]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2PFD7}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q2PFD7}. Postsynaptic density {ECO:0000250|UniProtKB:Q2PFD7}. Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions. {ECO:0000250|UniProtKB:Q2PFD7}.
Q9NYJ7	reviewed	DLL3_HUMAN	Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3)	DLL3	Homo sapiens (Human)	618	FUNCTION: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; compartment pattern specification [GO:0007386]; negative regulation of neurogenesis [GO:0050768]; negative regulation of Notch signaling pathway [GO:0045746]; Notch signaling pathway [GO:0007219]; paraxial mesoderm development [GO:0048339]; skeletal system development [GO:0001501]; somitogenesis [GO:0001756]	membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; Notch binding [GO:0005112]	membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; cell differentiation [GO:0030154]; compartment pattern specification [GO:0007386]; negative regulation of neurogenesis [GO:0050768]; negative regulation of Notch signaling pathway [GO:0045746]; Notch signaling pathway [GO:0007219]; paraxial mesoderm development [GO:0048339]; skeletal system development [GO:0001501]; somitogenesis [GO:0001756]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9NYJ8	reviewed	TAB2_HUMAN	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)	TAB2 KIAA0733 MAP3K7IP2	Homo sapiens (Human)	693	FUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:33184450, PubMed:36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). {ECO:0000250|UniProtKB:Q99K90, ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:20493459, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:33184450, ECO:0000269|PubMed:36681779}.		defense response to bacterium [GO:0042742]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of autophagy [GO:0010507]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein kinase activity [GO:0045860]; response to lipopolysaccharide [GO:0032496]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular adaptor activity [GO:0060090]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular adaptor activity [GO:0060090]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]; defense response to bacterium [GO:0042742]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of autophagy [GO:0010507]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein kinase activity [GO:0045860]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:24434549}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Endosome membrane {ECO:0000269|PubMed:24434549}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Lysosome membrane {ECO:0000269|PubMed:24434549}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Cytoplasm, cytosol {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:24434549, ECO:0000269|PubMed:36681779}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol (PubMed:10882101). Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome (PubMed:24434549). {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:24434549}.
Q9NYK1	reviewed	TLR7_HUMAN	Toll-like receptor 7	TLR7 UNQ248/PRO285	Homo sapiens (Human)	1049	FUNCTION: Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:31608988, PubMed:27742543, PubMed:12738885, PubMed:32706371, PubMed:35477763). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:27742543, PubMed:32706371). {ECO:0000269|PubMed:12738885, ECO:0000269|PubMed:14976261, ECO:0000269|PubMed:27742543, ECO:0000269|PubMed:31608988, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:32706371, ECO:0000269|PubMed:35477763}.		canonical NF-kappaB signal transduction [GO:0007249]; cellular response to mechanical stimulus [GO:0071260]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; I-kappaB phosphorylation [GO:0007252]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; positive regulation of chemokine production [GO:0032722]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; regulation of protein phosphorylation [GO:0001932]; response to cGMP [GO:0070305]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor signaling pathway [GO:0002224]	cytoplasm [GO:0005737]; early phagosome [GO:0032009]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	double-stranded RNA binding [GO:0003725]; pattern recognition receptor activity [GO:0038187]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]	cytoplasm [GO:0005737]; early phagosome [GO:0032009]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; double-stranded RNA binding [GO:0003725]; pattern recognition receptor activity [GO:0038187]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to mechanical stimulus [GO:0071260]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; I-kappaB phosphorylation [GO:0007252]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; positive regulation of chemokine production [GO:0032722]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; regulation of protein phosphorylation [GO:0001932]; response to cGMP [GO:0070305]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor signaling pathway [GO:0002224]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P58681}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P58681}. Endosome {ECO:0000250|UniProtKB:P58681}. Lysosome {ECO:0000250|UniProtKB:P58681}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P58681}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250|UniProtKB:P58681}.
Q9NYK5	reviewed	RM39_HUMAN	Large ribosomal subunit protein mL39 (39S ribosomal protein L39, mitochondrial) (L39mt) (MRP-L39) (39S ribosomal protein L5, mitochondrial) (L5mt) (MRP-L5)	MRPL39 C21orf92 MRPL5 RPML5 MSTP003 PRED22	Homo sapiens (Human)	338			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	nucleotide binding [GO:0000166]; RNA binding [GO:0003723]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9NYK6	reviewed	EURL_HUMAN	Protein EURL homolog	EURL C21orf14 C21orf38 C21orf91 YG81	Homo sapiens (Human)	297	FUNCTION: Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway. {ECO:0000250|UniProtKB:Q9D7G4}.		cerebral cortex neuron differentiation [GO:0021895]; positive regulation of dendritic spine development [GO:0060999]			cerebral cortex neuron differentiation [GO:0021895]; positive regulation of dendritic spine development [GO:0060999]	
Q9NYL2	reviewed	M3K20_HUMAN	Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)	MAP3K20 MLK7 MLTK ZAK HCCS4	Homo sapiens (Human)	800	FUNCTION: Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:32610081, PubMed:32289254, PubMed:35857590, PubMed:26999302). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32610081, PubMed:32289254, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32610081, PubMed:32289254, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32610081, PubMed:32289254). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32610081, PubMed:32289254). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32610081, PubMed:32289254, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.		cell death [GO:0008219]; cell differentiation [GO:0030154]; cellular response to gamma radiation [GO:0071480]; cellular response to UV-B [GO:0071493]; chromosome segregation [GO:0007059]; cytoskeleton organization [GO:0007010]; DNA damage checkpoint signaling [GO:0000077]; embryonic digit morphogenesis [GO:0042733]; GCN2-mediated signaling [GO:0140469]; JNK cascade [GO:0007254]; limb development [GO:0060173]; negative regulation of stress-activated protein kinase signaling cascade [GO:0070303]; negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of mitotic DNA damage checkpoint [GO:1904291]; positive regulation of programmed cell death [GO:0043068]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; pyroptosis [GO:0070269]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; stalled ribosome sensor activity [GO:0170011]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; stalled ribosome sensor activity [GO:0170011]; cell death [GO:0008219]; cell differentiation [GO:0030154]; cellular response to gamma radiation [GO:0071480]; cellular response to UV-B [GO:0071493]; chromosome segregation [GO:0007059]; cytoskeleton organization [GO:0007010]; DNA damage checkpoint signaling [GO:0000077]; embryonic digit morphogenesis [GO:0042733]; GCN2-mediated signaling [GO:0140469]; JNK cascade [GO:0007254]; limb development [GO:0060173]; negative regulation of stress-activated protein kinase signaling cascade [GO:0070303]; negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of mitotic DNA damage checkpoint [GO:1904291]; positive regulation of programmed cell death [GO:0043068]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; pyroptosis [GO:0070269]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15684425}. Nucleus {ECO:0000269|PubMed:15684425}. Note=Translocates to the nucleus upon ultraviolet B irradiation. {ECO:0000269|PubMed:15684425}.
Q9NYL5	reviewed	CP39A_HUMAN	24-hydroxycholesterol 7-alpha-hydroxylase (EC 1.14.14.26) (Cytochrome P450 39A1) (hCYP39A1) (Oxysterol 7-alpha-hydroxylase)	CYP39A1	Homo sapiens (Human)	469	FUNCTION: A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis (PubMed:25201972, PubMed:10748047). Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed:25201972, PubMed:10748047). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25201972, PubMed:10748047). {ECO:0000269|PubMed:10748047, ECO:0000269|PubMed:25201972}.		bile acid biosynthetic process [GO:0006699]; cholesterol catabolic process [GO:0006707]; cholesterol homeostasis [GO:0042632]; digestion [GO:0007586]; sterol metabolic process [GO:0016125]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	24-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033782]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxysterol 7-alpha-hydroxylase activity [GO:0008396]; steroid 7-alpha-hydroxylase activity [GO:0008387]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; 24-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033782]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxysterol 7-alpha-hydroxylase activity [GO:0008396]; steroid 7-alpha-hydroxylase activity [GO:0008387]; bile acid biosynthetic process [GO:0006699]; cholesterol catabolic process [GO:0006707]; cholesterol homeostasis [GO:0042632]; digestion [GO:0007586]; sterol metabolic process [GO:0016125]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64654}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:Q64654}; Multi-pass membrane protein {ECO:0000255}.
Q9NYM4	reviewed	GPR83_HUMAN	G-protein coupled receptor 83 (G-protein coupled receptor 72)	GPR83 GPR72 JP05 KIAA1540	Homo sapiens (Human)	423	FUNCTION: G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN (PubMed:27117253). Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity). {ECO:0000250|UniProtKB:P30731, ECO:0000269|PubMed:27117253}.	MISCELLANEOUS: NPY has been reported to be a ligand for GPR83 (in vitro) (By similarity). However, a more recent study found that radiolabeled PEN binding to GPR83 is not affected by NPY concentrations below 1 mM, only very high, non-physiological concentrations causes a partial, displacement of PEN binding (By similarity). {ECO:0000250|UniProtKB:P30731, ECO:0000250|UniProtKB:Q8VHD7}.	feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; response to glucocorticoid [GO:0051384]	cilium [GO:0005929]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]	cilium [GO:0005929]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; response to glucocorticoid [GO:0051384]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30731}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with GPR171 in the paraventricular nucleus. Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus. {ECO:0000250|UniProtKB:P30731}.
Q9NYP3	reviewed	DONS_HUMAN	Protein downstream neighbor of Son (B17)	DONSON C21orf60	Homo sapiens (Human)	566	FUNCTION: Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	DNA damage checkpoint signaling [GO:0000077]; DNA replication [GO:0006260]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; nuclear DNA replication [GO:0033260]; replication fork processing [GO:0031297]	nucleus [GO:0005634]; replication fork [GO:0005657]; replisome [GO:0030894]		nucleus [GO:0005634]; replication fork [GO:0005657]; replisome [GO:0030894]; DNA damage checkpoint signaling [GO:0000077]; DNA replication [GO:0006260]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; nuclear DNA replication [GO:0033260]; replication fork processing [GO:0031297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28191891}. Note=Localizes at DNA replication sites. {ECO:0000269|PubMed:28191891}.
Q9NYP7	reviewed	ELOV5_HUMAN	Elongation of very long chain fatty acids protein 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Fatty acid elongase 1) (hELO1) (Very long chain 3-ketoacyl-CoA synthase 5) (Very long chain 3-oxoacyl-CoA synthase 5)	ELOVL5 ELOVL2 PRO0530	Homo sapiens (Human)	299	FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity) (PubMed:10970790, PubMed:20937905). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity). {ECO:0000250|UniProtKB:Q8BHI7, ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:10970790, ECO:0000269|PubMed:20937905}.		alpha-linolenic acid metabolic process [GO:0036109]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; linoleic acid metabolic process [GO:0043651]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of fatty acid biosynthetic process [GO:0045723]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	dendrite [GO:0030425]; dendritic tree [GO:0097447]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; neuronal cell body [GO:0043025]	fatty acid elongase activity [GO:0009922]	dendrite [GO:0030425]; dendritic tree [GO:0097447]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; fatty acid elongase activity [GO:0009922]; alpha-linolenic acid metabolic process [GO:0036109]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; linoleic acid metabolic process [GO:0043651]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of fatty acid biosynthetic process [GO:0045723]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03205}. Cell projection, dendrite {ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:25065913}. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. {ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:25065913}.
Q9NYP9	reviewed	MS18A_HUMAN	Protein Mis18-alpha (FAPP1-associated protein 1)	MIS18A C21orf45 C21orf46 FASP1	Homo sapiens (Human)	233	FUNCTION: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}.		cell division [GO:0051301]; CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; regulation of DNA methylation [GO:0044030]	chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; cell division [GO:0051301]; CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; regulation of DNA methylation [GO:0044030]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17199038}. Chromosome {ECO:0000269|PubMed:17199038}. Chromosome, centromere {ECO:0000269|PubMed:17199038}. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
Q9NYQ3	reviewed	HAOX2_HUMAN	2-Hydroxyacid oxidase 2 (HAOX2) (EC 1.1.3.15) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Cell growth-inhibiting gene 16 protein) (Long chain alpha-hydroxy acid oxidase) (Long-chain L-2-hydroxy acid oxidase)	HAO2 HAOX2 GIG16	Homo sapiens (Human)	351	FUNCTION: Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, to the correspondong 2-oxoacids (PubMed:10777549). Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation (Probable). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2. Is not active on glycolate, glyoxylate, L-lactate and 2-hydroxybutanoate (PubMed:10777549). {ECO:0000269|PubMed:10777549, ECO:0000305|PubMed:10777549}.		fatty acid alpha-oxidation [GO:0001561]; fatty acid oxidation [GO:0019395]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	(S)-2-hydroxy-acid oxidase activity [GO:0003973]; FMN binding [GO:0010181]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; (S)-2-hydroxy-acid oxidase activity [GO:0003973]; FMN binding [GO:0010181]; fatty acid alpha-oxidation [GO:0001561]; fatty acid oxidation [GO:0019395]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:10777549}.
Q9NYQ6	reviewed	CELR1_HUMAN	Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2)	CELSR1 CDHF9 FMI2	Homo sapiens (Human)	3014	FUNCTION: Receptor that may have an important role in cell/cell signaling during nervous system formation.		apical protein localization [GO:0045176]; cell-cell adhesion [GO:0098609]; central nervous system development [GO:0007417]; establishment of body hair planar orientation [GO:0048105]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lateral sprouting involved in lung morphogenesis [GO:0060490]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060488]; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060489]; protein localization involved in establishment of planar polarity [GO:0090251]; regulation of actin cytoskeleton organization [GO:0032956]; Rho protein signal transduction [GO:0007266]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; apical protein localization [GO:0045176]; cell-cell adhesion [GO:0098609]; central nervous system development [GO:0007417]; establishment of body hair planar orientation [GO:0048105]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lateral sprouting involved in lung morphogenesis [GO:0060490]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060488]; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060489]; protein localization involved in establishment of planar polarity [GO:0090251]; regulation of actin cytoskeleton organization [GO:0032956]; Rho protein signal transduction [GO:0007266]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9NYQ7	reviewed	CELR3_HUMAN	Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2)	CELSR3 CDHF11 EGFL1 FMI1 KIAA0812 MEGF2	Homo sapiens (Human)	3312	FUNCTION: Receptor that may have an important role in cell/cell signaling during nervous system formation.		cell-cell adhesion [GO:0098609]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; cell-cell adhesion [GO:0098609]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9NYQ8	reviewed	FAT2_HUMAN	Protocadherin Fat 2 (hFat2) (Cadherin family member 8) (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1)	FAT2 CDHF8 KIAA0811 MEGF1	Homo sapiens (Human)	4349	FUNCTION: Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity). {ECO:0000250|UniProtKB:O88277, ECO:0000269|PubMed:18534823}.		cell-cell adhesion [GO:0098609]; cell-substrate adhesion [GO:0031589]; epithelial cell migration [GO:0010631]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	adherens junction [GO:0005912]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell-cell adhesion [GO:0098609]; cell-substrate adhesion [GO:0031589]; epithelial cell migration [GO:0010631]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction {ECO:0000269|PubMed:17900869}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O88277}. Note=Localized at adhesion zippers (early state of adherens junctions) of keratinocytes. {ECO:0000269|PubMed:17900869}.
Q9NYR8	reviewed	RDH8_HUMAN	Retinol dehydrogenase 8 (EC 1.1.1.300) (Photoreceptor outer segment all-trans retinol dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 2)	RDH8 PRRDH SDR28C2	Homo sapiens (Human)	311	FUNCTION: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity). {ECO:0000250|UniProtKB:Q9N126}.		estrogen biosynthetic process [GO:0006703]; response to stimulus [GO:0050896]; retinol metabolic process [GO:0042572]; steroid biosynthetic process [GO:0006694]; visual perception [GO:0007601]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; NAD-retinol dehydrogenase activity [GO:0004745]; NADP-retinol dehydrogenase activity [GO:0052650]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; NAD-retinol dehydrogenase activity [GO:0004745]; NADP-retinol dehydrogenase activity [GO:0052650]; estrogen biosynthetic process [GO:0006703]; response to stimulus [GO:0050896]; retinol metabolic process [GO:0042572]; steroid biosynthetic process [GO:0006694]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:10753906}; Multi-pass membrane protein {ECO:0000305}.
Q9NYR9	reviewed	KBRS2_HUMAN	NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (Kappa B-Ras protein 2) (KappaB-Ras2)	NKIRAS2 KBRAS2	Homo sapiens (Human)	191	FUNCTION: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). {ECO:0000250}.		canonical NF-kappaB signal transduction [GO:0007249]; inflammatory response [GO:0006954]; lung alveolus development [GO:0048286]; Ral protein signal transduction [GO:0032484]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; surfactant homeostasis [GO:0043129]	cytoplasm [GO:0005737]	GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924]; canonical NF-kappaB signal transduction [GO:0007249]; inflammatory response [GO:0006954]; lung alveolus development [GO:0048286]; Ral protein signal transduction [GO:0032484]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; surfactant homeostasis [GO:0043129]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9NYS0	reviewed	KBRS1_HUMAN	NF-kappa-B inhibitor-interacting Ras-like protein 1 (I-kappa-B-interacting Ras-like protein 1) (Kappa B-Ras protein 1) (KappaB-Ras1)	NKIRAS1 KBRAS1	Homo sapiens (Human)	192	FUNCTION: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. {ECO:0000269|PubMed:10657303, ECO:0000269|PubMed:12672800, ECO:0000269|PubMed:15024091}.		canonical NF-kappaB signal transduction [GO:0007249]; lung alveolus development [GO:0048286]; Ral protein signal transduction [GO:0032484]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; surfactant homeostasis [GO:0043129]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]	GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924]; canonical NF-kappaB signal transduction [GO:0007249]; lung alveolus development [GO:0048286]; Ral protein signal transduction [GO:0032484]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; surfactant homeostasis [GO:0043129]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15024091}.
Q9NYU1	reviewed	UGGG2_HUMAN	UDP-glucose:glycoprotein glucosyltransferase 2 (UGT2) (hUGT2) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase 2) (UDP-glucose ceramide glucosyltransferase-like 1)	UGGT2 UGCGL2 UGT2	Homo sapiens (Human)	1516	FUNCTION: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:24415556}.		ER-associated misfolded protein catabolic process [GO:0071712]; protein N-linked glycosylation via asparagine [GO:0018279]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; protein-containing complex [GO:0032991]	UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980]; unfolded protein binding [GO:0051082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; protein-containing complex [GO:0032991]; UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980]; unfolded protein binding [GO:0051082]; ER-associated misfolded protein catabolic process [GO:0071712]; protein N-linked glycosylation via asparagine [GO:0018279]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12913004}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12913004}.
Q9NYU2	reviewed	UGGG1_HUMAN	UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1)	UGGT1 GT UGCGL1 UGGT UGT1 UGTR	Homo sapiens (Human)	1555	FUNCTION: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:10694380}.		'de novo' post-translational protein folding [GO:0051084]; ER-associated misfolded protein catabolic process [GO:0071712]; protein N-linked glycosylation via asparagine [GO:0018279]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; protein-containing complex [GO:0032991]	UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980]; unfolded protein binding [GO:0051082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; protein-containing complex [GO:0032991]; UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980]; unfolded protein binding [GO:0051082]; 'de novo' post-translational protein folding [GO:0051084]; ER-associated misfolded protein catabolic process [GO:0071712]; protein N-linked glycosylation via asparagine [GO:0018279]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:10694380}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:10694380}.
Q9NYV4	reviewed	CDK12_HUMAN	Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)	CDK12 CRK7 CRKRS KIAA0904	Homo sapiens (Human)	1490	FUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.		mRNA processing [GO:0006397]; negative regulation of stem cell differentiation [GO:2000737]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein autophosphorylation [GO:0046777]; regulation of MAP kinase activity [GO:0043405]; RNA splicing [GO:0008380]; transcription by RNA polymerase II [GO:0006366]	cyclin K-CDK12 complex [GO:0002944]; cyclin/CDK positive transcription elongation factor complex [GO:0008024]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]	cyclin K-CDK12 complex [GO:0002944]; cyclin/CDK positive transcription elongation factor complex [GO:0008024]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; mRNA processing [GO:0006397]; negative regulation of stem cell differentiation [GO:2000737]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein autophosphorylation [GO:0046777]; regulation of MAP kinase activity [GO:0043405]; RNA splicing [GO:0008380]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11683387}. Nucleus speckle {ECO:0000269|PubMed:11683387}. Note=Colocalized with nuclear speckles throughout interphase. {ECO:0000269|PubMed:11683387}.
Q9NYV6	reviewed	RRN3_HUMAN	RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA)	RRN3 TIFIA	Homo sapiens (Human)	651	FUNCTION: Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity). {ECO:0000250, ECO:0000269|PubMed:10758157, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11265758, ECO:0000269|PubMed:15805466}.		cytoplasm organization [GO:0007028]; fibroblast proliferation [GO:0048144]; homeostasis of number of cells [GO:0048872]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; nucleolus organization [GO:0007000]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription initiation [GO:2000142]; ribosome biogenesis [GO:0042254]; transcription initiation at RNA polymerase I promoter [GO:0006361]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA polymerase I core binding [GO:0001042]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I core binding [GO:0001042]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; cytoplasm organization [GO:0007028]; fibroblast proliferation [GO:0048144]; homeostasis of number of cells [GO:0048872]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; nucleolus organization [GO:0007000]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription initiation [GO:2000142]; ribosome biogenesis [GO:0042254]; transcription initiation at RNA polymerase I promoter [GO:0006361]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11250903}.
Q9NYV7	reviewed	T2R16_HUMAN	Taste receptor type 2 member 16 (T2R16)	TAS2R16	Homo sapiens (Human)	291	FUNCTION: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. {ECO:0000269|PubMed:12379855, ECO:0000269|PubMed:15759003}.	MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell.; MISCELLANEOUS: Confers bitter perception of salicin to non-taster mice.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186]	endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]	endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16720576}; Multi-pass membrane protein {ECO:0000255}.
Q9NYW0	reviewed	T2R10_HUMAN	Taste receptor type 2 member 10 (T2R10) (Taste receptor family B member 2) (TRB2)	TAS2R10	Homo sapiens (Human)	307	FUNCTION: Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. {ECO:0000269|PubMed:15759003}.	MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NYW4	reviewed	TA2R5_HUMAN	Taste receptor type 2 member 5 (T2R5)	TAS2R5	Homo sapiens (Human)	299	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	chemosensory behavior [GO:0007635]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; chemosensory behavior [GO:0007635]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NYW5	reviewed	TA2R4_HUMAN	Taste receptor type 2 member 4 (T2R4)	TAS2R4	Homo sapiens (Human)	299	FUNCTION: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. {ECO:0000269|PubMed:19628819}.	MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; respiratory gaseous exchange by respiratory system [GO:0007585]	ciliary membrane [GO:0060170]; membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	ciliary membrane [GO:0060170]; membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:19628819}; Multi-pass membrane protein {ECO:0000269|PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269|PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia.
Q9NYW8	reviewed	RBAK_HUMAN	RB-associated KRAB zinc finger protein (RB-associated KRAB repressor) (hRBaK) (Zinc finger protein 769)	RBAK ZNF769	Homo sapiens (Human)	714	FUNCTION: May repress E2F-dependent transcription. May promote AR-dependent transcription. {ECO:0000269|PubMed:10702291, ECO:0000269|PubMed:14664718}.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10702291}.
Q9NYX4	reviewed	CALY_HUMAN	Neuron-specific vesicular protein calcyon	CALY DRD1IP	Homo sapiens (Human)	217	FUNCTION: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. {ECO:0000269|PubMed:16595675}.		anterograde axonal transport [GO:0008089]; clathrin coat assembly [GO:0048268]; dopamine receptor signaling pathway [GO:0007212]; endosomal transport [GO:0016197]; positive regulation of clathrin coat assembly [GO:1905445]; positive regulation of endocytosis [GO:0045807]; positive regulation of retrograde axon cargo transport [GO:2001019]; postsynaptic neurotransmitter receptor internalization [GO:0098884]	axon cytoplasm [GO:1904115]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic endocytic zone [GO:0098843]	clathrin light chain binding [GO:0032051]; protein-containing complex binding [GO:0044877]	axon cytoplasm [GO:1904115]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic endocytic zone [GO:0098843]; clathrin light chain binding [GO:0032051]; protein-containing complex binding [GO:0044877]; anterograde axonal transport [GO:0008089]; clathrin coat assembly [GO:0048268]; dopamine receptor signaling pathway [GO:0007212]; endosomal transport [GO:0016197]; positive regulation of clathrin coat assembly [GO:1905445]; positive regulation of endocytosis [GO:0045807]; positive regulation of retrograde axon cargo transport [GO:2001019]; postsynaptic neurotransmitter receptor internalization [GO:0098884]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
Q9NYY1	reviewed	IL20_HUMAN	Interleukin-20 (IL-20) (Cytokine Zcyto10)	IL20 ZCYTO10 UNQ852/PRO1801	Homo sapiens (Human)	176	FUNCTION: Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation (PubMed:17277128, PubMed:34403503). Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity (PubMed:17277128). Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration (PubMed:28424238). Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB (PubMed:11706020). Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB (PubMed:11564763). Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2 (By similarity). Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes (PubMed:23614738). {ECO:0000250|UniProtKB:Q9JKV9, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:16511554, ECO:0000269|PubMed:17277128, ECO:0000269|PubMed:23614738, ECO:0000269|PubMed:28424238, ECO:0000269|PubMed:34403503}.	MISCELLANEOUS: [Isoform 2]: Lung-specific. {ECO:0000305}.	osteoclast differentiation [GO:0030316]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of inflammatory response [GO:0050727]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; interleukin-20 receptor binding [GO:0045517]; interleukin-22 receptor binding [GO:0045518]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; interleukin-20 receptor binding [GO:0045517]; interleukin-22 receptor binding [GO:0045518]; osteoclast differentiation [GO:0030316]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34403503}.
Q9NYY3	reviewed	PLK2_HUMAN	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase)	PLK2 SNK	Homo sapiens (Human)	685	FUNCTION: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:20531387}.	MISCELLANEOUS: There are indications that PLK2 might act as a tumor suppressor: PLK2 is significantly down-regulated in a wide range of acute myeloid leukemias (AMLs) and B-cell lymphomas due to aberrant cytosine methylation in the CpG island located at the 5' of the PLK2 gene (PubMed:16160013, PubMed:21340720). Moreover, miR-126, a microRNA that negatively regulates PLK2 is up-regulated in AMLs, suggesting that PLK2 down-regulation by miR-126 could also contribute to leukemogenesis (PubMed:18832181). {ECO:0000305|PubMed:16160013, ECO:0000305|PubMed:18832181, ECO:0000305|PubMed:21340720}.	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitotic spindle organization [GO:0007052]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process in bone marrow cell [GO:0071866]; negative regulation of cellular senescence [GO:2000773]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of protein catabolic process [GO:0045732]; protein phosphorylation [GO:0006468]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of centriole replication [GO:0046599]; regulation of synaptic plasticity [GO:0048167]	centriole [GO:0005814]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinetochore [GO:0000776]; nucleus [GO:0005634]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; ATP-dependent protein binding [GO:0043008]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centriole [GO:0005814]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinetochore [GO:0000776]; nucleus [GO:0005634]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; ATP-dependent protein binding [GO:0043008]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitotic spindle organization [GO:0007052]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process in bone marrow cell [GO:0071866]; negative regulation of cellular senescence [GO:2000773]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of protein catabolic process [GO:0045732]; protein phosphorylation [GO:0006468]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of centriole replication [GO:0046599]; regulation of synaptic plasticity [GO:0048167]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
Q9NYY8	reviewed	FAKD2_HUMAN	FAST kinase domain-containing protein 2, mitochondrial	FASTKD2 KIAA0971	Homo sapiens (Human)	710	FUNCTION: Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664, PubMed:25683715, PubMed:26370583). May play a role in mitochondrial apoptosis. {ECO:0000269|PubMed:18771761, ECO:0000269|PubMed:25683715, ECO:0000269|PubMed:26370583, ECO:0000269|PubMed:27667664}.		apoptotic process [GO:0006915]; mitochondrial large ribosomal subunit assembly [GO:1902775]; mitochondrial RNA processing [GO:0000963]; mitochondrial translation [GO:0032543]; positive regulation of mitochondrial translation [GO:0070131]; regulation of mitochondrial mRNA stability [GO:0044528]; RNA processing [GO:0006396]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; apoptotic process [GO:0006915]; mitochondrial large ribosomal subunit assembly [GO:1902775]; mitochondrial RNA processing [GO:0000963]; mitochondrial translation [GO:0032543]; positive regulation of mitochondrial translation [GO:0070131]; regulation of mitochondrial mRNA stability [GO:0044528]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:25683715}. Mitochondrion matrix {ECO:0000305|PubMed:18771761}. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269|PubMed:25683715}.
Q9NYZ1	reviewed	TV23B_HUMAN	Golgi apparatus membrane protein TVP23 homolog B	TVP23B FAM18B FAM18B1 CGI-148 NPD008	Homo sapiens (Human)	205			protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]	membrane [GO:0016020]		membrane [GO:0016020]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NYZ2	reviewed	MFRN1_HUMAN	Mitoferrin-1 (Mitochondrial iron transporter 1) (Mitochondrial solute carrier protein) (Solute carrier family 25 member 37)	SLC25A37 MFRN MSCP HT015	Homo sapiens (Human)	338	FUNCTION: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. {ECO:0000269|PubMed:35513392}.		iron import into the mitochondrion [GO:0048250]; positive regulation of hemoglobin biosynthetic process [GO:0046985]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	ferrous iron transmembrane transporter activity [GO:0015093]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; ferrous iron transmembrane transporter activity [GO:0015093]; iron import into the mitochondrion [GO:0048250]; positive regulation of hemoglobin biosynthetic process [GO:0046985]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q287T7}; Multi-pass membrane protein {ECO:0000255}.
Q9NYZ3	reviewed	GTSE1_HUMAN	G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog)	GTSE1	Homo sapiens (Human)	720	FUNCTION: May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; microtubule-based process [GO:0007017]	cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]	microtubule binding [GO:0008017]	cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; microtubule binding [GO:0008017]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; microtubule-based process [GO:0007017]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Associated with microtubules.
Q9NYZ4	reviewed	SIGL8_HUMAN	Sialic acid-binding Ig-like lectin 8 (Siglec-8) (Sialoadhesin family member 2) (SAF-2)	SIGLEC8 SAF2	Homo sapiens (Human)	499	FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658). {ECO:0000269|PubMed:10625619, ECO:0000269|PubMed:10856141, ECO:0000269|PubMed:27357658}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell adhesion [GO:0007155]; signal transduction [GO:0007165]	membrane [GO:0016020]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; transmembrane signaling receptor activity [GO:0004888]; cell adhesion [GO:0007155]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9NZ01	reviewed	TECR_HUMAN	Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)	TECR GPSN2 SC2	Homo sapiens (Human)	308	FUNCTION: Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (PubMed:25049234). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (PubMed:12482854). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (PubMed:12482854). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (PubMed:12482854). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (PubMed:12482854). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (PubMed:25049234). {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:25049234}.		fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid metabolic process [GO:0006665]; very long-chain fatty acid biosynthetic process [GO:0042761]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	oxidoreductase activity [GO:0016491]; very-long-chain enoyl-CoA reductase activity [GO:0102758]; very-long-chain-acyl-CoA dehydrogenase activity [GO:0017099]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; oxidoreductase activity [GO:0016491]; very-long-chain enoyl-CoA reductase activity [GO:0102758]; very-long-chain-acyl-CoA dehydrogenase activity [GO:0017099]; fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid metabolic process [GO:0006665]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:24220030}; Multi-pass membrane protein {ECO:0000255}.
Q9NZ08	reviewed	ERAP1_HUMAN	Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator)	ERAP1 APPILS ARTS1 KIAA0525 UNQ584/PRO1154	Homo sapiens (Human)	941	FUNCTION: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. {ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653, ECO:0000269|PubMed:21478864}.		adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; fat cell differentiation [GO:0045444]; membrane protein ectodomain proteolysis [GO:0006509]; peptide catabolic process [GO:0043171]; positive regulation of angiogenesis [GO:0045766]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of innate immune response [GO:0045088]; response to bacterium [GO:0009617]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]	aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; interleukin-1, type II receptor binding [GO:0005151]; interleukin-6 receptor binding [GO:0005138]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; interleukin-1, type II receptor binding [GO:0005151]; interleukin-6 receptor binding [GO:0005138]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]; adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; fat cell differentiation [GO:0045444]; membrane protein ectodomain proteolysis [GO:0006509]; peptide catabolic process [GO:0043171]; positive regulation of angiogenesis [GO:0045766]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of innate immune response [GO:0045088]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:15908954}; Single-pass type II membrane protein {ECO:0000305|PubMed:15908954}.
Q9NZ09	reviewed	UBAP1_HUMAN	Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein)	UBAP1 NAG20	Homo sapiens (Human)	502	FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:24284069, PubMed:22405001, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}.		membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	ubiquitin binding [GO:0043130]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; ubiquitin binding [GO:0043130]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21757351}. Endosome {ECO:0000269|PubMed:21757351}. Note=Predominantly cytosolic (PubMed:21757351). Recruited to endosomes as part of the ESCRT-I complex (PubMed:21757351). {ECO:0000269|PubMed:21757351}.
Q9NZ20	reviewed	PA2G3_HUMAN	Group 3 secretory phospholipase A2 (EC 3.1.1.4) (Group III secretory phospholipase A2) (GIII sPLA2) (sPLA2-III) (Phosphatidylcholine 2-acylhydrolase 3)	PLA2G3	Homo sapiens (Human)	509	FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids without apparent head group selectivity (PubMed:12522102, PubMed:18801741, PubMed:15863501, PubMed:28947740). Contributes to phospholipid remodeling of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (PubMed:18801741). May act in an autocrine and paracrine manner (PubMed:23624557). Secreted by immature mast cells, acts on nearby fibroblasts upstream to PTDGS to synthesize prostaglandin D2 (PGD2), which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557). Secreted by epididymal epithelium, acts on immature sperm cells within the duct, modulating the degree of unsaturation of the fatty acyl components of phosphatidylcholines required for acrosome assembly and sperm cell motility. Facilitates the replacement of fatty acyl chains in phosphatidylcholines in sperm membranes from omega-6 and omega-9 to omega-3 polyunsaturated fatty acids (PUFAs). Coupled to lipoxygenase pathway, may process omega-6 PUFAs to generate oxygenated lipid mediators in the male reproductive tract (By similarity). At pericentrosomal preciliary compartment, negatively regulates ciliogenesis likely by regulating endocytotic recycling of ciliary membrane protein (PubMed:20393563). Coupled to cyclooxygenase pathway provides arachidonate to generate prostaglandin E2 (PGE2), a potent immunomodulatory lipid in inflammation and tumorigenesis (PubMed:12522102, PubMed:15863501). At colonic epithelial barrier, preferentially hydrolyzes phospholipids having arachidonate and docosahexaenoate at sn-2 position, contributing to the generation of oxygenated metabolites involved in colonic stem cell homeostasis (PubMed:28947740). Releases C16:0 and C18:0 lysophosphatidylcholine subclasses from neuron plasma membranes and promotes neurite outgrowth and neuron survival (PubMed:17868035). {ECO:0000250|UniProtKB:Q8BZT7, ECO:0000269|PubMed:12522102, ECO:0000269|PubMed:15863501, ECO:0000269|PubMed:17868035, ECO:0000269|PubMed:18801741, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:23624557, ECO:0000269|PubMed:28947740}.		acrosome assembly [GO:0001675]; arachidonic acid secretion [GO:0050482]; cell maturation [GO:0048469]; cilium assembly [GO:0060271]; high-density lipoprotein particle remodeling [GO:0034375]; lipoxygenase pathway [GO:0019372]; low-density lipoprotein particle remodeling [GO:0034374]; macrophage activation [GO:0042116]; mast cell degranulation [GO:0043303]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of histamine secretion by mast cell [GO:1903595]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of mast cell differentiation [GO:0060376]; positive regulation of neuron projection development [GO:0010976]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of prostaglandin secretion [GO:0032308]; production of molecular mediator involved in inflammatory response [GO:0002532]; regulation of endocytic recycling [GO:2001135]; sperm axoneme assembly [GO:0007288]	centriole [GO:0005814]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	calcium-dependent phospholipase A2 activity [GO:0047498]; metal ion binding [GO:0046872]	centriole [GO:0005814]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; calcium-dependent phospholipase A2 activity [GO:0047498]; metal ion binding [GO:0046872]; acrosome assembly [GO:0001675]; arachidonic acid secretion [GO:0050482]; cell maturation [GO:0048469]; cilium assembly [GO:0060271]; high-density lipoprotein particle remodeling [GO:0034375]; lipoxygenase pathway [GO:0019372]; low-density lipoprotein particle remodeling [GO:0034374]; macrophage activation [GO:0042116]; mast cell degranulation [GO:0043303]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of histamine secretion by mast cell [GO:1903595]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of mast cell differentiation [GO:0060376]; positive regulation of neuron projection development [GO:0010976]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of prostaglandin secretion [GO:0032308]; production of molecular mediator involved in inflammatory response [GO:0002532]; regulation of endocytic recycling [GO:2001135]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12522102}. Cell membrane {ECO:0000269|PubMed:12522102}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:20393563}. Recycling endosome {ECO:0000269|PubMed:20393563}. Note=Localized at pericentrosomal preciliary compartment. {ECO:0000269|PubMed:20393563}.
Q9NZ42	reviewed	PEN2_HUMAN	Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2)	PSENEN PEN2 MDS033	Homo sapiens (Human)	101	FUNCTION: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). {ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:12763021, ECO:0000269|PubMed:24941111, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000305}.		amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]; amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12639958}; Multi-pass membrane protein {ECO:0000269|PubMed:12639958, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12639958}; Multi-pass membrane protein {ECO:0000269|PubMed:12639958, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Cell membrane {ECO:0000269|PubMed:24941111}; Multi-pass membrane protein {ECO:0000269|PubMed:12639958, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517}. Membrane {ECO:0000269|PubMed:12198112}; Multi-pass membrane protein {ECO:0000269|PubMed:12639958, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. {ECO:0000269|PubMed:12639958}.
Q9NZ43	reviewed	USE1_HUMAN	Vesicle transport protein USE1 (Putative MAPK-activating protein PM26) (USE1-like protein) (p31)	USE1 USE1L MDS032	Homo sapiens (Human)	259	FUNCTION: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}.		lysosomal transport [GO:0007041]; protein catabolic process [GO:0030163]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; secretion by cell [GO:0032940]	COPI-coated vesicle [GO:0030137]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SNARE complex [GO:0031201]	SNAP receptor activity [GO:0005484]	COPI-coated vesicle [GO:0030137]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SNARE complex [GO:0031201]; SNAP receptor activity [GO:0005484]; lysosomal transport [GO:0007041]; protein catabolic process [GO:0030163]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; secretion by cell [GO:0032940]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15029241}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15029241}.
Q9NZ45	reviewed	CISD1_HUMAN	CDGSH iron-sulfur domain-containing protein 1 (Cysteine transaminase CISD1) (EC 2.6.1.3) (MitoNEET)	CISD1 C10orf70 ZCD1 MDS029	Homo sapiens (Human)	108	FUNCTION: L-cysteine transaminase that catalyzes the reversible transfer of the amino group from L-cysteine to the alpha-keto acid 2-oxoglutarate to respectively form 2-oxo-3-sulfanylpropanoate and L-glutamate (PubMed:36194135). The catalytic cycle occurs in the presence of pyridoxal 5'-phosphate (PLP) cofactor that facilitates transamination by initially forming an internal aldimine with the epsilon-amino group of active site Lys-55 residue on the enzyme (PLP-enzyme aldimine), subsequently displaced by formation of an external aldimine with the substrate amino group (PLP-L-cysteine aldimine). The external aldimine is further deprotonated to form a carbanion intermediate, which in the presence of 2-oxoglutarate regenerates PLP yielding final products 2-oxo-3-sulfanylpropanoate and L-glutamate. The proton transfer in carbanion intermediate is suggested to be controlled by the active site lysine residue, whereas PLP stabilizes carbanion structure through electron delocalization, also known as the electron sink effect (PubMed:36194135). Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in iron-sulfur cluster shuttling and/or in redox reactions. Can transfer the [2Fe-2S] cluster to an apo-acceptor protein only when in the oxidation state, likely serving as a redox sensor that regulates mitochondrial iron-sulfur cluster assembly and iron trafficking upon oxidative stress (PubMed:21788481, PubMed:23758282, PubMed:17584744). {ECO:0000250, ECO:0000250|UniProtKB:Q91WS0, ECO:0000269|PubMed:17584744, ECO:0000269|PubMed:17766440, ECO:0000269|PubMed:21788481, ECO:0000269|PubMed:23758282, ECO:0000269|PubMed:36194135}.	MISCELLANEOUS: Binds pioglitazone, an anti-diabetes drug. Binding increases the stability of the 2Fe-2S cluster.	protein maturation by [2Fe-2S] cluster transfer [GO:0106034]; regulation of autophagy [GO:0010506]; regulation of cellular respiration [GO:0043457]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	2 iron, 2 sulfur cluster binding [GO:0051537]; identical protein binding [GO:0042802]; L-cysteine transaminase activity [GO:0047801]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; identical protein binding [GO:0042802]; L-cysteine transaminase activity [GO:0047801]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; protein maturation by [2Fe-2S] cluster transfer [GO:0106034]; regulation of autophagy [GO:0010506]; regulation of cellular respiration [GO:0043457]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:17376863, ECO:0000269|PubMed:17766439, ECO:0000269|PubMed:17905743, ECO:0000269|PubMed:18047834}; Single-pass type III membrane protein {ECO:0000269|PubMed:17376863, ECO:0000269|PubMed:17766439, ECO:0000269|PubMed:17905743, ECO:0000269|PubMed:18047834}.
Q9NZ52	reviewed	GGA3_HUMAN	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)	GGA3 KIAA0154	Homo sapiens (Human)	723	FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:17553422, PubMed:15615712, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}.		endocytic recycling [GO:0032456]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; negative regulation of amyloid-beta formation [GO:1902430]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to cell surface [GO:0034394]; protein targeting to lysosome [GO:0006622]; regulation of protein stability [GO:0031647]	early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; protein-containing complex [GO:0032991]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]	phosphatidylinositol binding [GO:0035091]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130]	early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; protein-containing complex [GO:0032991]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; phosphatidylinositol binding [GO:0035091]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130]; endocytic recycling [GO:0032456]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; negative regulation of amyloid-beta formation [GO:1902430]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to cell surface [GO:0034394]; protein targeting to lysosome [GO:0006622]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:10749927, ECO:0000269|PubMed:15039775}; Peripheral membrane protein {ECO:0000269|PubMed:10749927, ECO:0000269|PubMed:15039775}. Endosome membrane {ECO:0000269|PubMed:15039775}; Peripheral membrane protein {ECO:0000269|PubMed:15039775}. Early endosome membrane {ECO:0000269|PubMed:11950392}; Peripheral membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000250|UniProtKB:A0A0G2JV04}; Peripheral membrane protein {ECO:0000305}.
Q9NZ53	reviewed	PDXL2_HUMAN	Podocalyxin-like protein 2 (Endoglycan)	PODXL2 UNQ1861/PRO3742	Homo sapiens (Human)	605	FUNCTION: Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. {ECO:0000269|PubMed:18606703}.		leukocyte tethering or rolling [GO:0050901]	Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	glycosaminoglycan binding [GO:0005539]	Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; glycosaminoglycan binding [GO:0005539]; leukocyte tethering or rolling [GO:0050901]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9NZ56	reviewed	FMN2_HUMAN	Formin-2	FMN2	Homo sapiens (Human)	1722	FUNCTION: Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:22330775, PubMed:21730168). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:22330775, PubMed:21730168). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}.		actin cytoskeleton organization [GO:0030036]; cell migration [GO:0016477]; cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; homologous chromosome movement towards spindle pole in meiosis I anaphase [GO:0051758]; intracellular signal transduction [GO:0035556]; intracellular transport [GO:0046907]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; oogenesis [GO:0048477]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; microvillus [GO:0005902]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819]	actin binding [GO:0003779]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; microvillus [GO:0005902]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819]; actin binding [GO:0003779]; actin cytoskeleton organization [GO:0030036]; cell migration [GO:0016477]; cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; homologous chromosome movement towards spindle pole in meiosis I anaphase [GO:0051758]; intracellular signal transduction [GO:0035556]; intracellular transport [GO:0046907]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; oogenesis [GO:0048477]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20082305}. Cytoplasm, cytosol {ECO:0000269|PubMed:20082305}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9JL04}. Nucleus {ECO:0000269|PubMed:26287480}. Nucleus, nucleolus {ECO:0000269|PubMed:23375502}. Cell membrane {ECO:0000250|UniProtKB:Q9JL04}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JL04}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JL04}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9JL04}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JL04}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JL04}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9JL04}. Note=Colocalizes with the actin cytoskeleton (PubMed:20082305). Recruited to the membranes via its interaction with SPIRE1 (By similarity). Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Accumulates in the nucleus following DNA damage (PubMed:26287480). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:20082305, ECO:0000269|PubMed:26287480}.
Q9NZ63	reviewed	TLS1_HUMAN	Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59)	C9orf78 HCA59	Homo sapiens (Human)	289	FUNCTION: Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}.		chromosome segregation [GO:0007059]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; regulation of homologous chromosome segregation [GO:0060629]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	U5 snRNA binding [GO:0030623]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U5 snRNA binding [GO:0030623]; chromosome segregation [GO:0007059]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; regulation of homologous chromosome segregation [GO:0060629]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35167828}. Chromosome, centromere {ECO:0000269|PubMed:35167828}. Note=Dispersed throughout the nucleus during interphase (PubMed:35167828). Colocalizes with microtubule attachment sites at centromeres following mitotic checkpoint activation (PubMed:35167828). {ECO:0000269|PubMed:35167828}.
Q9NZ71	reviewed	RTEL1_HUMAN	Regulator of telomere elongation helicase 1 (EC 3.6.4.12) (Novel helicase-like)	RTEL1 C20orf41 KIAA1088 NHL	Homo sapiens (Human)	1219	FUNCTION: ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:18957201, ECO:0000269|PubMed:23453664, ECO:0000269|PubMed:24009516}.	MISCELLANEOUS: Amplified in gastric tumors.; MISCELLANEOUS: [Isoform 1]: Variant in position: 1264:R->H (in DKCB5), abolishes activity. {ECO:0000305}.	DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; negative regulation of DNA recombination [GO:0045910]; negative regulation of t-circle formation [GO:1904430]; negative regulation of telomere maintenance in response to DNA damage [GO:1904506]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of telomeric loop disassembly [GO:1904535]; regulation of double-strand break repair via homologous recombination [GO:0010569]; replication fork processing [GO:0031297]; strand displacement [GO:0000732]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]; telomeric loop disassembly [GO:0090657]	chromosome, telomeric region [GO:0000781]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA polymerase binding [GO:0070182]; metal ion binding [GO:0046872]	chromosome, telomeric region [GO:0000781]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA polymerase binding [GO:0070182]; metal ion binding [GO:0046872]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; negative regulation of DNA recombination [GO:0045910]; negative regulation of t-circle formation [GO:1904430]; negative regulation of telomere maintenance in response to DNA damage [GO:1904506]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of telomeric loop disassembly [GO:1904535]; regulation of double-strand break repair via homologous recombination [GO:0010569]; replication fork processing [GO:0031297]; strand displacement [GO:0000732]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]; telomeric loop disassembly [GO:0090657]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:23585563}. Note=Colocalizes with PCNA within the replication foci in S-phase cells. {ECO:0000255|HAMAP-Rule:MF_03065}.
Q9NZ72	reviewed	STMN3_HUMAN	Stathmin-3 (SCG10-like protein)	STMN3 SCLIP	Homo sapiens (Human)	180	FUNCTION: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. {ECO:0000250}.		blastocyst hatching [GO:0001835]; cytoplasmic microtubule organization [GO:0031122]; microtubule depolymerization [GO:0007019]; negative regulation of Rac protein signal transduction [GO:0035021]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; regulation of cytoskeleton organization [GO:0051493]; regulation of GTPase activity [GO:0043087]; regulation of microtubule polymerization or depolymerization [GO:0031110]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005]	protein domain specific binding [GO:0019904]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005]; protein domain specific binding [GO:0019904]; tubulin binding [GO:0015631]; blastocyst hatching [GO:0001835]; cytoplasmic microtubule organization [GO:0031122]; microtubule depolymerization [GO:0007019]; negative regulation of Rac protein signal transduction [GO:0035021]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; regulation of cytoskeleton organization [GO:0051493]; regulation of GTPase activity [GO:0043087]; regulation of microtubule polymerization or depolymerization [GO:0031110]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:21471001}. Cell projection, growth cone {ECO:0000269|PubMed:21471001}. Cell projection, axon {ECO:0000269|PubMed:21471001}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JHU6}.
Q9NZ81	reviewed	PRR13_HUMAN	Proline-rich protein 13 (Taxane-resistance protein)	PRR13 TXR1 BM-041	Homo sapiens (Human)	148	FUNCTION: Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis. {ECO:0000269|PubMed:16847352}.			cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16847352}.
Q9NZ94	reviewed	NLGN3_HUMAN	Neuroligin-3 (Gliotactin homolog)	NLGN3 KIAA1480 NL3	Homo sapiens (Human)	848	FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity). {ECO:0000250, ECO:0000269|PubMed:15620359}.		adult behavior [GO:0030534]; axon extension [GO:0048675]; chemical synaptic transmission [GO:0007268]; inhibitory postsynaptic potential [GO:0060080]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; positive regulation of AMPA receptor activity [GO:2000969]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; receptor-mediated endocytosis [GO:0006898]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; rhythmic synaptic transmission [GO:0060024]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488]; vocalization behavior [GO:0071625]	asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; excitatory synapse [GO:0060076]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]	cell adhesion molecule binding [GO:0050839]; neurexin family protein binding [GO:0042043]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]	asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; excitatory synapse [GO:0060076]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]; cell adhesion molecule binding [GO:0050839]; neurexin family protein binding [GO:0042043]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]; adult behavior [GO:0030534]; axon extension [GO:0048675]; chemical synaptic transmission [GO:0007268]; inhibitory postsynaptic potential [GO:0060080]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; positive regulation of AMPA receptor activity [GO:2000969]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; receptor-mediated endocytosis [GO:0006898]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; rhythmic synaptic transmission [GO:0060024]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Note=Detected at both glutamatergic and GABAergic synapses. {ECO:0000250}.
Q9NZA1	reviewed	CLIC5_HUMAN	Chloride intracellular channel protein 5	CLIC5	Homo sapiens (Human)	410	FUNCTION: Required for normal hearing (PubMed:24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315). Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity). {ECO:0000250|UniProtKB:Q8BXK9, ECO:0000269|PubMed:15184393, ECO:0000269|PubMed:18028448, ECO:0000269|PubMed:20335315, ECO:0000269|PubMed:24781754}.		chloride transport [GO:0006821]; female pregnancy [GO:0007565]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to stimulus [GO:0050896]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; stereocilium bundle [GO:0032421]	chloride channel activity [GO:0005254]; voltage-gated monoatomic ion channel activity [GO:0005244]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; stereocilium bundle [GO:0032421]; chloride channel activity [GO:0005254]; voltage-gated monoatomic ion channel activity [GO:0005244]; chloride transport [GO:0006821]; female pregnancy [GO:0007565]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to stimulus [GO:0050896]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:15184393}. Cytoplasm, cell cortex {ECO:0000269|PubMed:15184393}. Membrane {ECO:0000269|PubMed:15184393, ECO:0000305|PubMed:18028448}; Single-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:20335315}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:O00299}. Mitochondrion {ECO:0000250|UniProtKB:Q9EPT8}. Note=Associates with the cortical actin cytoskeleton (PubMed:10793131, PubMed:15184393). Localizes to the apical region of cochlear hair cells, at the base of the actin-rich hair bundle (By similarity). Colocalizes with podocalyxin at the apical cell membrane in renal glomeruli (PubMed:20335315). May localize to the centrosome in lens epithelial cells (By similarity). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250|UniProtKB:O00299, ECO:0000250|UniProtKB:Q8BXK9, ECO:0000250|UniProtKB:Q9EPT8, ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:15184393, ECO:0000269|PubMed:20335315}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus {ECO:0000269|PubMed:12163479}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12163479}. Note=Colocalizes with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome. {ECO:0000269|PubMed:12163479}.
Q9NZB2	reviewed	F120A_HUMAN	Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A)	FAM120A C9orf10 KIAA0183 OSSA	Homo sapiens (Human)	1118	FUNCTION: Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}.			cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	RNA binding [GO:0003723]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19015244}. Cell membrane {ECO:0000269|PubMed:19015244}; Peripheral membrane protein {ECO:0000305|PubMed:19015244}; Cytoplasmic side {ECO:0000305|PubMed:19015244}. Note=Translocates from the cytosol to plasma membrane after UV irradiation. {ECO:0000269|PubMed:19015244}.
Q9NZB8	reviewed	MOCS1_HUMAN	Molybdenum cofactor biosynthesis protein 1 (Cell migration-inducing gene 11 protein) (Molybdenum cofactor synthesis-step 1 protein A-B) [Includes: GTP 3',8-cyclase (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)]	MOCS1 MIG11	Homo sapiens (Human)	636	FUNCTION: Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP. {ECO:0000269|PubMed:11891227}.	MISCELLANEOUS: The MOCS1 locus has initially been reported to produce MOCS1A and MOCS1B from non-overlapping reading frames within a bicistronic transcript. However, only isoform MOCS1A seems to be translated from the bicistronic transcript. Isoform MOCS1B seems to be translated from a monocistronic mRNA that is derived by alternative splicing.; MISCELLANEOUS: [Isoform MOCS1B]: Multidomain protein with inactive MOCS1A and active MOCS1B.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Multidomain protein with inactive MOCS1A and active MOCS1B. {ECO:0000305}.	Mo-molybdopterin cofactor biosynthetic process [GO:0006777]	cytosol [GO:0005829]; molybdopterin synthase complex [GO:0019008]; nucleus [GO:0005634]	4 iron, 4 sulfur cluster binding [GO:0051539]; cyclic pyranopterin monophosphate synthase activity [GO:0061799]; GTP 3',8'-cyclase activity [GO:0061798]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]	cytosol [GO:0005829]; molybdopterin synthase complex [GO:0019008]; nucleus [GO:0005634]; 4 iron, 4 sulfur cluster binding [GO:0051539]; cyclic pyranopterin monophosphate synthase activity [GO:0061799]; GTP 3',8'-cyclase activity [GO:0061798]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]	
Q9NZC2	reviewed	TREM2_HUMAN	Triggering receptor expressed on myeloid cells 2 (TREM-2) (Triggering receptor expressed on monocytes 2)	TREM2	Homo sapiens (Human)	230	FUNCTION: Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia (PubMed:27477018, PubMed:29518356). Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (By similarity). Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia (PubMed:27477018). Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin (PubMed:29794134). Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (By similarity). Required for microglial phagocytosis of apoptotic neurons (PubMed:24990881). Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (By similarity). Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (By similarity). It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (By similarity). During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (By similarity). Plays a role in microglial MTOR activation and metabolism (By similarity). Regulates age-related changes in microglial numbers (PubMed:29752066). Triggers activation of the immune responses in macrophages and dendritic cells (PubMed:10799849). Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). Involved in the positive regulation of osteoclast differentiation (PubMed:12925681). {ECO:0000250|UniProtKB:Q99NH8, ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:11602640, ECO:0000269|PubMed:12925681, ECO:0000269|PubMed:24990881, ECO:0000269|PubMed:27477018, ECO:0000269|PubMed:29518356, ECO:0000269|PubMed:29752066, ECO:0000269|PubMed:29794134}.		amyloid-beta clearance by cellular catabolic process [GO:0150094]; apoptotic cell clearance [GO:0043277]; astrocyte activation [GO:0048143]; cellular response to amyloid-beta [GO:1904646]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to lipid [GO:0071396]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to peptidoglycan [GO:0071224]; complement-mediated synapse pruning [GO:0150062]; CXCL12-activated CXCR4 signaling pathway [GO:0038160]; defense response to Gram-negative bacterium [GO:0050829]; dendritic cell differentiation [GO:0097028]; dendritic spine maintenance [GO:0097062]; detection of lipopolysaccharide [GO:0032497]; detection of lipoteichoic acid [GO:0070392]; detection of peptidoglycan [GO:0032499]; excitatory synapse pruning [GO:1905805]; humoral immune response [GO:0006959]; import into cell [GO:0098657]; lipid homeostasis [GO:0055088]; memory [GO:0007613]; microglial cell activation [GO:0001774]; microglial cell activation involved in immune response [GO:0002282]; microglial cell proliferation [GO:0061518]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of astrocyte activation [GO:0061889]; negative regulation of autophagic cell death [GO:1904093]; negative regulation of autophagy [GO:0010507]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell activation [GO:0050866]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of macrophage colony-stimulating factor signaling pathway [GO:1902227]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of sequestering of triglyceride [GO:0010891]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of tumor necrosis factor production [GO:0032720]; osteoclast differentiation [GO:0030316]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002588]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of C-C chemokine receptor CCR7 signaling pathway [GO:1903082]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of CAMKK-AMPK signaling cascade [GO:1905291]; positive regulation of CD40 signaling pathway [GO:2000350]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of complement activation, classical pathway [GO:0045960]; positive regulation of engulfment of apoptotic cell [GO:1901076]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of gene expression [GO:0010628]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of inward rectifier potassium channel activity [GO:1901980]; positive regulation of kinase activity [GO:0033674]; positive regulation of low-density lipoprotein particle clearance [GO:1905581]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of mitochondrion organization [GO:0010822]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of synapse pruning [GO:1905808]; positive regulation of TOR signaling [GO:0032008]; pyroptosis [GO:0070269]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of gene expression [GO:0010468]; regulation of hippocampal neuron apoptotic process [GO:0110089]; regulation of innate immune response [GO:0045088]; regulation of interleukin-6 production [GO:0032675]; regulation of intracellular signal transduction [GO:1902531]; regulation of lipid metabolic process [GO:0019216]; regulation of macrophage inflammatory protein 1 alpha production [GO:0071640]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of plasma membrane bounded cell projection organization [GO:0120035]; regulation of resting membrane potential [GO:0060075]; regulation of toll-like receptor 6 signaling pathway [GO:0034151]; regulation of TOR signaling [GO:0032006]; respiratory burst after phagocytosis [GO:0045728]; response to axon injury [GO:0048678]; response to ischemia [GO:0002931]; social behavior [GO:0035176]	cell surface [GO:0009986]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]	amyloid-beta binding [GO:0001540]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein binding [GO:0034185]; high-density lipoprotein particle binding [GO:0008035]; kinase activator activity [GO:0019209]; lipid binding [GO:0008289]; lipopolysaccharide binding [GO:0001530]; lipoprotein particle binding [GO:0071813]; lipoteichoic acid binding [GO:0070891]; low-density lipoprotein particle binding [GO:0030169]; peptidoglycan binding [GO:0042834]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylserine binding [GO:0001786]; phospholipid binding [GO:0005543]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]; sulfatide binding [GO:0120146]; transmembrane signaling receptor activity [GO:0004888]; very-low-density lipoprotein particle binding [GO:0034189]	cell surface [GO:0009986]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; amyloid-beta binding [GO:0001540]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein binding [GO:0034185]; high-density lipoprotein particle binding [GO:0008035]; kinase activator activity [GO:0019209]; lipid binding [GO:0008289]; lipopolysaccharide binding [GO:0001530]; lipoprotein particle binding [GO:0071813]; lipoteichoic acid binding [GO:0070891]; low-density lipoprotein particle binding [GO:0030169]; peptidoglycan binding [GO:0042834]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylserine binding [GO:0001786]; phospholipid binding [GO:0005543]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]; sulfatide binding [GO:0120146]; transmembrane signaling receptor activity [GO:0004888]; very-low-density lipoprotein particle binding [GO:0034189]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; apoptotic cell clearance [GO:0043277]; astrocyte activation [GO:0048143]; cellular response to amyloid-beta [GO:1904646]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to lipid [GO:0071396]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to peptidoglycan [GO:0071224]; complement-mediated synapse pruning [GO:0150062]; CXCL12-activated CXCR4 signaling pathway [GO:0038160]; defense response to Gram-negative bacterium [GO:0050829]; dendritic cell differentiation [GO:0097028]; dendritic spine maintenance [GO:0097062]; detection of lipopolysaccharide [GO:0032497]; detection of lipoteichoic acid [GO:0070392]; detection of peptidoglycan [GO:0032499]; excitatory synapse pruning [GO:1905805]; humoral immune response [GO:0006959]; import into cell [GO:0098657]; lipid homeostasis [GO:0055088]; memory [GO:0007613]; microglial cell activation [GO:0001774]; microglial cell activation involved in immune response [GO:0002282]; microglial cell proliferation [GO:0061518]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of astrocyte activation [GO:0061889]; negative regulation of autophagic cell death [GO:1904093]; negative regulation of autophagy [GO:0010507]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell activation [GO:0050866]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of macrophage colony-stimulating factor signaling pathway [GO:1902227]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of sequestering of triglyceride [GO:0010891]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of tumor necrosis factor production [GO:0032720]; osteoclast differentiation [GO:0030316]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002588]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of C-C chemokine receptor CCR7 signaling pathway [GO:1903082]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of CAMKK-AMPK signaling cascade [GO:1905291]; positive regulation of CD40 signaling pathway [GO:2000350]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of complement activation, classical pathway [GO:0045960]; positive regulation of engulfment of apoptotic cell [GO:1901076]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of gene expression [GO:0010628]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of inward rectifier potassium channel activity [GO:1901980]; positive regulation of kinase activity [GO:0033674]; positive regulation of low-density lipoprotein particle clearance [GO:1905581]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of mitochondrion organization [GO:0010822]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of synapse pruning [GO:1905808]; positive regulation of TOR signaling [GO:0032008]; pyroptosis [GO:0070269]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of gene expression [GO:0010468]; regulation of hippocampal neuron apoptotic process [GO:0110089]; regulation of innate immune response [GO:0045088]; regulation of interleukin-6 production [GO:0032675]; regulation of intracellular signal transduction [GO:1902531]; regulation of lipid metabolic process [GO:0019216]; regulation of macrophage inflammatory protein 1 alpha production [GO:0071640]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of plasma membrane bounded cell projection organization [GO:0120035]; regulation of resting membrane potential [GO:0060075]; regulation of toll-like receptor 6 signaling pathway [GO:0034151]; regulation of TOR signaling [GO:0032006]; respiratory burst after phagocytosis [GO:0045728]; response to axon injury [GO:0048678]; response to ischemia [GO:0002931]; social behavior [GO:0035176]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:24078628, ECO:0000269|PubMed:24990881, ECO:0000269|PubMed:25615530, ECO:0000269|PubMed:27589997, ECO:0000269|PubMed:27995897, ECO:0000269|PubMed:28768830, ECO:0000269|PubMed:28855300, ECO:0000269|PubMed:28855301}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.
Q9NZC3	reviewed	GDE1_HUMAN	Glycerophosphodiester phosphodiesterase 1 (Glycerophosphoinositol glycerophosphodiesterase GDE1) (EC 3.1.4.44) (Lysophospholipase D GDE1) (EC 3.1.4.-) (Membrane-interacting protein of RGS16) (RGS16-interacting membrane protein)	GDE1 MIR16	Homo sapiens (Human)	331	FUNCTION: Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (By similarity). {ECO:0000250|UniProtKB:Q9JL55, ECO:0000250|UniProtKB:Q9JL56}.		ethanolamine metabolic process [GO:0006580]; glycerophospholipid catabolic process [GO:0046475]; lipid metabolic process [GO:0006629]; N-acylethanolamine metabolic process [GO:0070291]; phospholipid metabolic process [GO:0006644]	cytoplasmic vesicle membrane [GO:0030659]; membrane [GO:0016020]; plasma membrane [GO:0005886]	glycerophosphodiester phosphodiesterase activity [GO:0008889]; glycerophosphoinositol glycerophosphodiesterase activity [GO:0047395]; lysophospholipase activity [GO:0004622]; metal ion binding [GO:0046872]	cytoplasmic vesicle membrane [GO:0030659]; membrane [GO:0016020]; plasma membrane [GO:0005886]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; glycerophosphoinositol glycerophosphodiesterase activity [GO:0047395]; lysophospholipase activity [GO:0004622]; metal ion binding [GO:0046872]; ethanolamine metabolic process [GO:0006580]; glycerophospholipid catabolic process [GO:0046475]; lipid metabolic process [GO:0006629]; N-acylethanolamine metabolic process [GO:0070291]; phospholipid metabolic process [GO:0006644]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9JL55}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9JL55}; Multi-pass membrane protein {ECO:0000255}. Note=Perinuclear vesicles and cell membrane. {ECO:0000250|UniProtKB:Q9JL55}.
Q9NZC4	reviewed	EHF_HUMAN	ETS homologous factor (hEHF) (ETS domain-containing transcription factor) (Epithelium-specific Ets transcription factor 3) (ESE-3)	EHF ESE3 ESE3B ESEJ	Homo sapiens (Human)	300	FUNCTION: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. {ECO:0000269|PubMed:10527851, ECO:0000269|PubMed:10644770, ECO:0000269|PubMed:11259407, ECO:0000269|PubMed:12444029, ECO:0000269|PubMed:17027647}.		epithelial cell differentiation [GO:0030855]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; epithelial cell differentiation [GO:0030855]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:11259407, ECO:0000269|PubMed:12444029}.
Q9NZC7	reviewed	WWOX_HUMAN	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1)	WWOX FOR SDR41C1 WOX1	Homo sapiens (Human)	414	FUNCTION: Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. {ECO:0000250, ECO:0000269|PubMed:11719429, ECO:0000269|PubMed:15070730, ECO:0000269|PubMed:15548692, ECO:0000269|PubMed:16061658, ECO:0000269|PubMed:16219768, ECO:0000269|PubMed:19366691, ECO:0000269|PubMed:19465938}.		cellular response to transforming growth factor beta stimulus [GO:0071560]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of Wnt signaling pathway [GO:0030178]; osteoblast differentiation [GO:0001649]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal system morphogenesis [GO:0048705]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; oxidoreductase activity [GO:0016491]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; oxidoreductase activity [GO:0016491]; transcription coactivator activity [GO:0003713]; cellular response to transforming growth factor beta stimulus [GO:0071560]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of Wnt signaling pathway [GO:0030178]; osteoblast differentiation [GO:0001649]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal system morphogenesis [GO:0048705]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:15070730, ECO:0000269|PubMed:16219768, ECO:0000269|PubMed:19366691, ECO:0000269|PubMed:19465938}. Nucleus {ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:15064722, ECO:0000269|PubMed:16219768, ECO:0000269|PubMed:19366691}. Mitochondrion {ECO:0000269|PubMed:14695174}. Golgi apparatus {ECO:0000269|PubMed:30285739}. Lysosome {ECO:0000269|PubMed:30285739}. Note=Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus. Localized to the lysosome probably upon binding to VOPP1 (PubMed:30285739). {ECO:0000250, ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:19366691, ECO:0000269|PubMed:30285739}.
Q9NZC9	reviewed	SMAL1_HUMAN	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1)	SMARCAL1 HARP	Homo sapiens (Human)	954	FUNCTION: ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via nonhomologous end joining [GO:0006303]; regulation of transcription by RNA polymerase II [GO:0006357]; replication fork processing [GO:0031297]; t-circle formation [GO:0090656]	nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]	nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via nonhomologous end joining [GO:0006303]; regulation of transcription by RNA polymerase II [GO:0006357]; replication fork processing [GO:0031297]; t-circle formation [GO:0090656]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19793862, ECO:0000269|PubMed:19793863}. Note=Recruited to damaged DNA regions.
Q9NZD1	reviewed	GPC5D_HUMAN	G-protein coupled receptor family C group 5 member D	GPRC5D	Homo sapiens (Human)	345				extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295]	extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11311935}; Multi-pass membrane protein {ECO:0000269|PubMed:11311935}.
Q9NZD2	reviewed	GLTP_HUMAN	Glycolipid transfer protein (GLTP)	GLTP	Homo sapiens (Human)	209	FUNCTION: Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides. {ECO:0000269|PubMed:15329726, ECO:0000269|PubMed:15504043, ECO:0000269|PubMed:17980653, ECO:0000269|PubMed:18261224}.		ER to Golgi ceramide transport [GO:0035621]; glycosphingolipid metabolic process [GO:0006687]; intermembrane lipid transfer [GO:0120009]; response to immobilization stress [GO:0035902]	cytosol [GO:0005829]	ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; glycolipid binding [GO:0051861]; glycolipid transfer activity [GO:0017089]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipid transfer activity [GO:0120013]	cytosol [GO:0005829]; ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; glycolipid binding [GO:0051861]; glycolipid transfer activity [GO:0017089]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipid transfer activity [GO:0120013]; ER to Golgi ceramide transport [GO:0035621]; glycosphingolipid metabolic process [GO:0006687]; intermembrane lipid transfer [GO:0120009]; response to immobilization stress [GO:0035902]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17980653}.
Q9NZD4	reviewed	AHSP_HUMAN	Alpha-hemoglobin-stabilizing protein (Erythroid differentiation-related factor) (Erythroid-associated factor)	AHSP EDRF ERAF	Homo sapiens (Human)	102	FUNCTION: Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. {ECO:0000269|PubMed:12066189}.		erythrocyte differentiation [GO:0030218]; hemoglobin metabolic process [GO:0020027]; hemopoiesis [GO:0030097]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	cytoplasm [GO:0005737]; hemoglobin complex [GO:0005833]	hemoglobin binding [GO:0030492]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; hemoglobin complex [GO:0005833]; hemoglobin binding [GO:0030492]; unfolded protein binding [GO:0051082]; erythrocyte differentiation [GO:0030218]; hemoglobin metabolic process [GO:0020027]; hemopoiesis [GO:0030097]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12066189}.
Q9NZD8	reviewed	SPG21_HUMAN	Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein)	SPG21 ACP33 BM-019 GL010	Homo sapiens (Human)	308	FUNCTION: May play a role as a negative regulatory factor in CD4-dependent T-cell activation. {ECO:0000269|PubMed:11113139}.		antigen receptor-mediated signaling pathway [GO:0050851]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network transport vesicle [GO:0030140]	CD4 receptor binding [GO:0042609]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network transport vesicle [GO:0030140]; CD4 receptor binding [GO:0042609]; antigen receptor-mediated signaling pathway [GO:0050851]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11113139}. Membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Endosome membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans-Golgi network.
Q9NZE8	reviewed	RM35_HUMAN	Large ribosomal subunit protein bL35m (39S ribosomal protein L35, mitochondrial) (L35mt) (MRP-L35)	MRPL35 BM-007	Homo sapiens (Human)	188			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9NZG7	reviewed	NINJ2_HUMAN	Ninjurin-2 (Nerve injury-induced protein 2)	NINJ2	Homo sapiens (Human)	142	FUNCTION: Effector of necroptotic and pyroptotic programmed cell death that mediates plasma membrane rupture (cytolysis) (By similarity). Acts downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively: oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Also acts as a homophilic transmembrane adhesion molecule involved in nerve regeneration (PubMed:10627596). Promotes axonal growth (PubMed:10627596). {ECO:0000250|UniProtKB:Q92982, ECO:0000269|PubMed:10627596}.		cell adhesion [GO:0007155]; nervous system development [GO:0007399]; neuron cell-cell adhesion [GO:0007158]; tissue regeneration [GO:0042246]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cell adhesion [GO:0007155]; nervous system development [GO:0007399]; neuron cell-cell adhesion [GO:0007158]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NZH0	reviewed	GPC5B_HUMAN	G-protein coupled receptor family C group 5 member B (A-69G12.1) (Retinoic acid-induced gene 2 protein) (RAIG-2)	GPRC5B RAIG2	Homo sapiens (Human)	403	FUNCTION: Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.		positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein tyrosine kinase activity [GO:0061098]	cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]	cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein tyrosine kinase activity [GO:0061098]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10945465}; Multi-pass membrane protein {ECO:0000269|PubMed:10945465}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10945465}; Multi-pass membrane protein {ECO:0000269|PubMed:10945465}. Note=Localized in the plasma membrane and perinuclear vesicles.
Q9NZH6	reviewed	IL37_HUMAN	Interleukin-37 (IL-37) (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1)	IL37 FIL1Z IL1F7 IL1H4 IL1RP1	Homo sapiens (Human)	218	FUNCTION: Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647, ECO:0000269|PubMed:33674380}.	MISCELLANEOUS: [Isoform B]: The name IL-HL refers to isoform B containing polymorphisms Val-31 and Ala-42. {ECO:0000305|PubMed:11145836}.	cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of gene expression [GO:0010628]; regulation of inflammatory response [GO:0050727]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of gene expression [GO:0010628]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647}. Nucleus {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647, ECO:0000269|PubMed:33674380}. Secreted {ECO:0000269|PubMed:11145836, ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33674380}. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647, PubMed:33674380). Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059, PubMed:33674380). {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33674380}.
Q9NZH7	reviewed	IL36B_HUMAN	Interleukin-36 beta (FIL1 eta) (Interleukin-1 eta) (IL-1 eta) (Interleukin-1 family member 8) (IL-1F8) (Interleukin-1 homolog 2) (IL-1H2)	IL36B IL1F8 IL1H2	Homo sapiens (Human)	164	FUNCTION: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6. {ECO:0000269|PubMed:16646978, ECO:0000269|PubMed:20300079, ECO:0000269|PubMed:21242515, ECO:0000269|PubMed:21881584, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:24829417}.		cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; positive regulation of gene expression [GO:0010628]; positive regulation of T cell differentiation [GO:0045582]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; positive regulation of gene expression [GO:0010628]; positive regulation of T cell differentiation [GO:0045582]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:16646978}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}.
Q9NZH8	reviewed	IL36G_HUMAN	Interleukin-36 gamma (IL-1-related protein 2) (IL-1RP2) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 9) (IL-1F9) (Interleukin-1 homolog 1) (IL-1H1)	IL36G IL1E IL1F9 IL1H1 IL1RP2 UNQ2456/PRO5737	Homo sapiens (Human)	169	FUNCTION: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous pro-inflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:20870894, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23095752, ECO:0000269|PubMed:23147407, ECO:0000269|PubMed:24829417}.		cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; positive regulation of gene expression [GO:0010628]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149]	cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; positive regulation of gene expression [GO:0010628]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:20870894}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}.
Q9NZI2	reviewed	KCIP1_HUMAN	Kv channel-interacting protein 1 (KChIP1) (A-type potassium channel modulatory protein 1) (Potassium channel-interacting protein 1) (Vesicle APC-binding protein)	KCNIP1 KCHIP1 VABP	Homo sapiens (Human)	227	FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface. {ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11423117, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:17187064}.		regulation of potassium ion transmembrane transport [GO:1901379]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	calcium ion binding [GO:0005509]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity [GO:0005244]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; calcium ion binding [GO:0005509]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity [GO:0005244]; regulation of potassium ion transmembrane transport [GO:1901379]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10676964}; Peripheral membrane protein {ECO:0000305|PubMed:10676964}. Cytoplasm {ECO:0000269|PubMed:10676964}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8R426}.
Q9NZI5	reviewed	GRHL1_HUMAN	Grainyhead-like protein 1 homolog (Mammalian grainyhead) (NH32) (Transcription factor CP2-like 2) (Transcription factor LBP-32)	GRHL1 LBP32 MGR TFCP2L2	Homo sapiens (Human)	618	FUNCTION: Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, nor functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). May play a role in regulating glucose homeostasis and insulin signaling. {ECO:0000250|UniProtKB:Q921D9, ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:18288204, ECO:0000269|PubMed:29309642, ECO:0000269|PubMed:35013237}.; FUNCTION: [Isoform 1]: Functions as transcription activator. {ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:29309642}.; FUNCTION: [Isoform 2]: May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed. {ECO:0000269|PubMed:12175488}.	MISCELLANEOUS: GRHL genes (GRHL1, GRHL2 and GRHL3) show a paradoxical lack of redundancy despite their extensive sequence identity in the DNA-binding and protein dimerization domains and the fact that the core consensus DNA binding sites are identical. They have related but remarkably different functions during embryogenesis because of their differential spatiotemporal expression patterns during development. {ECO:0000250|UniProtKB:Q921D9}.	desmosome organization [GO:0002934]; epidermis development [GO:0008544]; establishment of skin barrier [GO:0061436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of keratinocyte differentiation [GO:0045616]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; desmosome organization [GO:0002934]; epidermis development [GO:0008544]; establishment of skin barrier [GO:0061436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of keratinocyte differentiation [GO:0045616]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18288204, ECO:0000269|PubMed:35013237}.
Q9NZI6	reviewed	TF2L1_HUMAN	Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1) (Transcription factor LBP-9)	TFCP2L1 CRTR1 LBP9	Homo sapiens (Human)	479	FUNCTION: Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752). {ECO:0000250|UniProtKB:Q3UNW5, ECO:0000269|PubMed:10644752, ECO:0000269|PubMed:25215486, ECO:0000269|PubMed:26906118}.		cell morphogenesis [GO:0000902]; cytoplasm organization [GO:0007028]; determination of adult lifespan [GO:0008340]; epithelial cell maturation [GO:0002070]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of growth [GO:0045927]; regulation of transcription by RNA polymerase II [GO:0006357]; salivary gland development [GO:0007431]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell morphogenesis [GO:0000902]; cytoplasm organization [GO:0007028]; determination of adult lifespan [GO:0008340]; epithelial cell maturation [GO:0002070]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of growth [GO:0045927]; regulation of transcription by RNA polymerase II [GO:0006357]; salivary gland development [GO:0007431]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10644752}.
Q9NZI7	reviewed	UBIP1_HUMAN	Upstream-binding protein 1 (Transcription factor LBP-1)	UBP1 LBP1	Homo sapiens (Human)	540	FUNCTION: Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. {ECO:0000250, ECO:0000269|PubMed:10644752, ECO:0000269|PubMed:2006421, ECO:0000269|PubMed:8114710}.		angiogenesis [GO:0001525]; negative regulation of viral transcription [GO:0032897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; angiogenesis [GO:0001525]; negative regulation of viral transcription [GO:0032897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8114710}.
Q9NZI8	reviewed	IF2B1_HUMAN	Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1)	IGF2BP1 CRDBP VICKZ1 ZBP1	Homo sapiens (Human)	577	FUNCTION: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152, PubMed:32245947). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence preventing MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD (PubMed:29476152). Binding to MYC mRNA is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. {ECO:0000250, ECO:0000269|PubMed:10875929, ECO:0000269|PubMed:16356927, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:16778892, ECO:0000269|PubMed:17101699, ECO:0000269|PubMed:17255263, ECO:0000269|PubMed:17893325, ECO:0000269|PubMed:18385235, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19541769, ECO:0000269|PubMed:19647520, ECO:0000269|PubMed:20080952, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8132663, ECO:0000269|PubMed:9891060}.		CRD-mediated mRNA stabilization [GO:0070934]; dendrite arborization [GO:0140059]; mRNA transport [GO:0051028]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; neuronal stem cell population maintenance [GO:0097150]; pallium cell proliferation in forebrain [GO:0022013]; positive regulation of cytoplasmic translation [GO:2000767]; regulation of cytokine production [GO:0001817]; regulation of gene expression [GO:0010468]; regulation of mRNA stability involved in response to stress [GO:0010610]	CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182]	CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182]; CRD-mediated mRNA stabilization [GO:0070934]; dendrite arborization [GO:0140059]; mRNA transport [GO:0051028]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; neuronal stem cell population maintenance [GO:0097150]; pallium cell proliferation in forebrain [GO:0022013]; positive regulation of cytoplasmic translation [GO:2000767]; regulation of cytokine production [GO:0001817]; regulation of gene expression [GO:0010468]; regulation of mRNA stability involved in response to stress [GO:0010610]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, P-body {ECO:0000269|PubMed:29476152}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29476152}. Cell projection, lamellipodium. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell projection, growth cone. Cell projection, filopodium {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=In the nucleus, located in discrete foci, coinciding with the sites of ACTB transcription (By similarity). In the cytoplasm, localizes in cytoplasmic mRNP granules. Colocalizes with microtubules in growth cone filopodia and along neurites in neuronal cells (By similarity). Cytoplasmic colocalization with ACTB mRNA is partially lost at the cell periphery, suggesting release of the transcript. In neuronal processes, exhibits fast retrograde and anterograde movements, when associated with ACTB mRNA; this motility is lost when the association is inhibited (By similarity). In hippocampal neurons, predominantly located within dendrites, particularly at dendritic branching points in young cells, compared to axons (By similarity). In axons, predominantly found in axonal branches and their growth cones (By similarity). In motile cells, such as migrating fibroblasts, localizes to leading edges where it colocalizes with microtubules and microfilaments and to retracting tails (By similarity). Dendritic levels are regulated by neuronal activity and glutaminergic signals: they are increased by KCl-induced depolarization, which induces rapid efflux from the cell body into dendrites, and decreased by the NMDA receptor agonist (By similarity). In motile cells, transported towards the leading edge into the cortical region of the lamellipodia where it is connected to microfilaments (By similarity). In response to cellular stress, such as oxidative stress or heat shock, recruited to stress granules, but not to processing bodies. {ECO:0000250}.
Q9NZJ0	reviewed	DTL_HUMAN	Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)	DTL CDT2 CDW1 DCAF2 L2DTL RAMP	Homo sapiens (Human)	730	FUNCTION: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}.		DNA damage response [GO:0006974]; DNA replication [GO:0006260]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; translesion synthesis [GO:0019985]; ubiquitin-dependent protein catabolic process [GO:0006511]	centrosome [GO:0005813]; chromosome [GO:0005694]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein-macromolecule adaptor activity [GO:0030674]	centrosome [GO:0005813]; chromosome [GO:0005694]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-macromolecule adaptor activity [GO:0030674]; DNA damage response [GO:0006974]; DNA replication [GO:0006260]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; translesion synthesis [GO:0019985]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26431207}. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Note=Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.
Q9NZJ4	reviewed	SACS_HUMAN	Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29)	SACS KIAA0730	Homo sapiens (Human)	4579	FUNCTION: Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins. {ECO:0000269|PubMed:19208651}.		negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]	axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]; negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19208651}. Note=Predominantly cytoplasmic, a small portion is present in the nucleus and also shows a partial mitochondrial overlap with the mitochondrial marker Hsp60.
Q9NZJ5	reviewed	E2AK3_HUMAN	Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK)	EIF2AK3 PEK PERK	Homo sapiens (Human)	1116	FUNCTION: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:33384352). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity). {ECO:0000250|UniProtKB:Q9Z2B5, ECO:0000269|PubMed:33384352}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; angiogenesis [GO:0001525]; bone mineralization [GO:0030282]; calcium-mediated signaling [GO:0019722]; cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to glucose starvation [GO:0042149]; chondrocyte development [GO:0002063]; eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492]; endocrine pancreas development [GO:0031018]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of myelination [GO:0031642]; negative regulation of translation [GO:0017148]; negative regulation of translation in response to stress [GO:0032055]; negative regulation of translational initiation in response to stress [GO:0032057]; ossification [GO:0001503]; peptidyl-serine phosphorylation [GO:0018105]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:0060734]; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902235]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; response to endoplasmic reticulum stress [GO:0034976]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; skeletal system development [GO:0001501]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; angiogenesis [GO:0001525]; bone mineralization [GO:0030282]; calcium-mediated signaling [GO:0019722]; cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to glucose starvation [GO:0042149]; chondrocyte development [GO:0002063]; eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492]; endocrine pancreas development [GO:0031018]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of myelination [GO:0031642]; negative regulation of translation [GO:0017148]; negative regulation of translation in response to stress [GO:0032055]; negative regulation of translational initiation in response to stress [GO:0032057]; ossification [GO:0001503]; peptidyl-serine phosphorylation [GO:0018105]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:0060734]; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902235]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; response to endoplasmic reticulum stress [GO:0034976]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Q9NZJ6	reviewed	COQ3_HUMAN	Ubiquinone biosynthesis O-methyltransferase, mitochondrial (3-demethylubiquinol 3-O-methyltransferase) (EC 2.1.1.64) (Polyprenyldihydroxybenzoate methyltransferase) (EC 2.1.1.114)	COQ3 UG0215E05	Homo sapiens (Human)	369	FUNCTION: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. {ECO:0000255|HAMAP-Rule:MF_03190}.		glycerol metabolic process [GO:0006071]; methylation [GO:0032259]; regulation of ubiquinone biosynthetic process [GO:0010795]; ubiquinone biosynthetic process [GO:0006744]	extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ubiquinone biosynthesis complex [GO:0110142]	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [GO:0008425]; 3-demethylubiquinol-10 3-O-methyltransferase activity [GO:0044596]; 3-demethylubiquinol-n 3-O-methyltransferase activity [GO:0061542]; 3-demethylubiquinone-9 3-O-methyltransferase activity [GO:0008689]; decaprenyldihydroxybenzoate methyltransferase activity [GO:0044595]; hexaprenyldihydroxybenzoate methyltransferase activity [GO:0004395]; O-methyltransferase activity [GO:0008171]	extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ubiquinone biosynthesis complex [GO:0110142]; 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [GO:0008425]; 3-demethylubiquinol-10 3-O-methyltransferase activity [GO:0044596]; 3-demethylubiquinol-n 3-O-methyltransferase activity [GO:0061542]; 3-demethylubiquinone-9 3-O-methyltransferase activity [GO:0008689]; decaprenyldihydroxybenzoate methyltransferase activity [GO:0044595]; hexaprenyldihydroxybenzoate methyltransferase activity [GO:0004395]; O-methyltransferase activity [GO:0008171]; glycerol metabolic process [GO:0006071]; methylation [GO:0032259]; regulation of ubiquinone biosynthetic process [GO:0010795]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03190}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03190}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03190}.
Q9NZJ7	reviewed	MTCH1_HUMAN	Mitochondrial carrier homolog 1 (Presenilin-associated protein)	MTCH1 PSAP CGI-64 UNQ1871/PRO4314	Homo sapiens (Human)	389	FUNCTION: Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (By similarity). Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). May play a role in apoptosis (PubMed:12377771). {ECO:0000250|UniProtKB:Q9Y6C9, ECO:0000269|PubMed:12377771, ECO:0000269|PubMed:36264797}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; neuronal ion channel clustering [GO:0045161]; positive regulation of apoptotic process [GO:0043065]; protein insertion into mitochondrial outer membrane [GO:0045040]; regulation of signal transduction [GO:0009966]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	membrane insertase activity [GO:0032977]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; membrane insertase activity [GO:0032977]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; neuronal ion channel clustering [GO:0045161]; positive regulation of apoptotic process [GO:0043065]; protein insertion into mitochondrial outer membrane [GO:0045040]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000305|PubMed:12377771}; Multi-pass membrane protein {ECO:0000255}.
Q9NZJ9	reviewed	NUDT4_HUMAN	Diphosphoinositol polyphosphate phosphohydrolase 2 (DIPP-2) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2) (Nucleoside diphosphate-linked moiety X motif 4) (Nudix motif 4)	NUDT4 DIPP2 KIAA0487 HDCMB47P	Homo sapiens (Human)	180	FUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568, PubMed:12370170). Can also catalyze the hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) but not diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A (PubMed:12370170). Also able to hydrolyze 5-phosphoribose 1-diphosphate (PubMed:12370170). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q8R2U6, ECO:0000269|PubMed:10777568, ECO:0000269|PubMed:12370170}.		adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; calcium-mediated signaling [GO:0019722]; cyclic-nucleotide-mediated signaling [GO:0019935]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543]; intracellular signal transduction [GO:0035556]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [GO:0052848]; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [GO:0052845]; metal ion binding [GO:0046872]; snoRNA binding [GO:0030515]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [GO:0052848]; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [GO:0052845]; metal ion binding [GO:0046872]; snoRNA binding [GO:0030515]; adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; calcium-mediated signaling [GO:0019722]; cyclic-nucleotide-mediated signaling [GO:0019935]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543]; intracellular signal transduction [GO:0035556]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12121577}.
Q9NZK5	reviewed	ADA2_HUMAN	Adenosine deaminase 2 (EC 3.5.4.4) (Cat eye syndrome critical region protein 1)	ADA2 ADGF CECR1 IDGFL	Homo sapiens (Human)	511	FUNCTION: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. {ECO:0000269|PubMed:20147294, ECO:0000269|PubMed:20453107}.	MISCELLANEOUS: Candidate gene for the Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. Duplication usually takes in the form of a surpernumerary bisatellited isodicentric chromosome, resulting in four copies of the region (represents an inv dup(22)(q11)). CES is characterized clinically by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development.	adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103]	azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; adenosine receptor binding [GO:0031685]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; zinc ion binding [GO:0008270]	azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; 2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; adenosine receptor binding [GO:0031685]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; zinc ion binding [GO:0008270]; adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15926889, ECO:0000269|PubMed:20147294, ECO:0000269|PubMed:20453107}.
Q9NZK7	reviewed	PA2GE_HUMAN	Group IIE secretory phospholipase A2 (GIIE sPLA2) (sPLA2-IIE) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2E)	PLA2G2E	Homo sapiens (Human)	142	FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:10681567, PubMed:11922621, PubMed:28883454). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), releasing various unsaturated fatty acids including oleoate, linoleoate, arachidonate, docosahexaenoate and lysophosphatidylethanolamines in preference to lysophosphatidylcholines (PubMed:10681567, PubMed:28883454). In response to high-fat diet, hydrolyzes minor lipoprotein phospholipids including phosphatidylserines, phosphatidylinositols and phosphatidylglycerols, altering lipoprotein composition and fat storage in adipose tissue and liver (By similarity). May act in an autocrine and paracrine manner (PubMed:11922621). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (PubMed:11922621). Acts as a hair follicle phospholipase A2. Selectively releases lysophosphatidylethanolamines (LPE) and various unsaturated fatty acids in skin to regulate hair follicle homeostasis (By similarity). May regulate the inflammatory response by releasing arachidonate, a precursor of prostaglandins and leukotrienes (PubMed:11922621). Upon allergen exposure, may participate in allergic inflammatory response by enhancing leukotriene C4 synthesis and degranulation in mast cells (By similarity). {ECO:0000250|UniProtKB:Q9QUL3, ECO:0000269|PubMed:10681567, ECO:0000269|PubMed:11922621, ECO:0000269|PubMed:28883454}.		arachidonic acid secretion [GO:0050482]; inflammatory response [GO:0006954]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of T cell proliferation [GO:0042130]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543]; arachidonic acid secretion [GO:0050482]; inflammatory response [GO:0006954]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of T cell proliferation [GO:0042130]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10681567, ECO:0000269|PubMed:11922621}. Cytoplasm {ECO:0000269|PubMed:11922621}. Note=Through binding to heparan sulfate proteoglycan, may be localized to cytoplasmic compartments enriched in anionic phospholipids. {ECO:0000269|PubMed:11922621}.
Q9NZL3	reviewed	ZN224_HUMAN	Zinc finger protein 224 (Bone marrow zinc finger 2) (BMZF-2) (Zinc finger protein 233) (Zinc finger protein 255) (Zinc finger protein 27) (Zinc finger protein KOX22)	ZNF224 BMZF2 KOX22 ZNF233 ZNF255 ZNF27	Homo sapiens (Human)	707	FUNCTION: May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269|PubMed:20587513}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12239212, ECO:0000269|PubMed:20587513, ECO:0000269|PubMed:23665872}. Note=Colocalizes with DEPDC1A at the nucleus.
Q9NZL4	reviewed	HPBP1_HUMAN	Hsp70-binding protein 1 (HspBP1) (Heat shock protein-binding protein 1) (Hsp70-binding protein 2) (HspBP2) (Hsp70-interacting protein 1) (Hsp70-interacting protein 2)	HSPBP1 HSPBP PP1845	Homo sapiens (Human)	359	FUNCTION: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. {ECO:0000269|PubMed:10786638, ECO:0000269|PubMed:12651857, ECO:0000269|PubMed:15215316, ECO:0000269|PubMed:21247889, ECO:0000269|PubMed:9830037}.		positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein folding [GO:0006457]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]	adenyl-nucleotide exchange factor activity [GO:0000774]; enzyme inhibitor activity [GO:0004857]; molecular sequestering activity [GO:0140313]; ubiquitin protein ligase binding [GO:0031625]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; adenyl-nucleotide exchange factor activity [GO:0000774]; enzyme inhibitor activity [GO:0004857]; molecular sequestering activity [GO:0140313]; ubiquitin protein ligase binding [GO:0031625]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein folding [GO:0006457]	
Q9NZL9	reviewed	MAT2B_HUMAN	Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase)	MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995	Homo sapiens (Human)	334	FUNCTION: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}.	MISCELLANEOUS: Its expression in hepatoma cell lines may lead to increase DNA synthesis and thereby participate in cell proliferation.	one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; methionine adenosyltransferase complex [GO:0048269]; nucleus [GO:0005634]	enzyme binding [GO:0019899]; methionine adenosyltransferase regulator activity [GO:0048270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; methionine adenosyltransferase complex [GO:0048269]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; methionine adenosyltransferase regulator activity [GO:0048270]; one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556]	
Q9NZM1	reviewed	MYOF_HUMAN	Myoferlin (Fer-1-like protein 3)	MYOF FER1L3 KIAA1207	Homo sapiens (Human)	2061	FUNCTION: Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}.		blood circulation [GO:0008015]; muscle contraction [GO:0006936]; plasma membrane repair [GO:0001778]; regulation of neurotransmitter secretion [GO:0046928]	caveola [GO:0005901]; centriolar satellite [GO:0034451]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543]	caveola [GO:0005901]; centriolar satellite [GO:0034451]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543]; blood circulation [GO:0008015]; muscle contraction [GO:0006936]; plasma membrane repair [GO:0001778]; regulation of neurotransmitter secretion [GO:0046928]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Nucleus membrane; Single-pass type II membrane protein. Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Note=Concentrated at the membrane sites of both myoblast-myoblast and myoblast-myotube fusions. Detected at the plasmalemma in endothelial cells lining intact blood vessels (By similarity). Found at nuclear and plasma membranes. Enriched in undifferentiated myoblasts near the plasma membrane in puncate structures. {ECO:0000250}.
Q9NZM3	reviewed	ITSN2_HUMAN	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)	ITSN2 KIAA1256 SH3D1B SWAP	Homo sapiens (Human)	1697	FUNCTION: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}.	MISCELLANEOUS: Overexpression results in the inhibition of the transferrin uptake and the blockage of the clathrin-mediated endocytosis.	cell differentiation [GO:0030154]; clathrin-dependent synaptic vesicle endocytosis [GO:0150007]; endosomal transport [GO:0016197]; positive regulation of dendrite extension [GO:1903861]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular vesicle [GO:0097708]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular vesicle [GO:0097708]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090]; cell differentiation [GO:0030154]; clathrin-dependent synaptic vesicle endocytosis [GO:0150007]; endosomal transport [GO:0016197]; positive regulation of dendrite extension [GO:1903861]	SUBCELLULAR LOCATION: Cytoplasm.
Q9NZM4	reviewed	BICRA_HUMAN	BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein)	BICRA GLTSCR1	Homo sapiens (Human)	1560	FUNCTION: Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269|PubMed:21555454, ECO:0000269|PubMed:29374058}.		chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]	transcription regulator activator activity [GO:0140537]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]; transcription regulator activator activity [GO:0140537]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21555454}.
Q9NZM5	reviewed	NOP53_HUMAN	Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60)	NOP53 GLT GLTSCR2 PICT1	Homo sapiens (Human)	478	FUNCTION: Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (PubMed:27824081). {ECO:0000269|PubMed:15355975, ECO:0000269|PubMed:16971513, ECO:0000269|PubMed:21167305, ECO:0000269|PubMed:21741933, ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:24556985, ECO:0000269|PubMed:25818168, ECO:0000269|PubMed:25956029, ECO:0000269|PubMed:27729611, ECO:0000269|PubMed:27824081, ECO:0000269|PubMed:27829214}.		cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; protein localization to nucleolus [GO:1902570]; protein localization to nucleoplasm [GO:1990173]; protein stabilization [GO:0050821]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of protein phosphorylation [GO:0001932]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	5S rRNA binding [GO:0008097]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; RNA binding [GO:0003723]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; 5S rRNA binding [GO:0008097]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; protein localization to nucleolus [GO:1902570]; protein localization to nucleoplasm [GO:1990173]; protein stabilization [GO:0050821]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of protein phosphorylation [GO:0001932]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10196275, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20042497, ECO:0000269|PubMed:22292050, ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24923447, ECO:0000269|PubMed:25956029, ECO:0000269|PubMed:27729611, ECO:0000269|PubMed:27829214}. Nucleus, nucleoplasm {ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24923447, ECO:0000269|PubMed:26903295, ECO:0000269|PubMed:27323397}. Note=In the nucleolus may be more specifically localized to the fibrillar center (PubMed:27729611). Mainly nucleolar it relocalizes to the nucleoplasm under specific conditions including ribosomal stress enabling it to interact and regulate nucleoplasmic proteins like p53/TP53 (PubMed:22522597, PubMed:24923447, PubMed:27323397, PubMed:26903295). Also detected in the cytosol (PubMed:24923447, PubMed:27824081). {ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24923447, ECO:0000269|PubMed:26903295, ECO:0000269|PubMed:27323397, ECO:0000269|PubMed:27729611, ECO:0000269|PubMed:27824081}.
Q9NZM6	reviewed	PK2L2_HUMAN	Polycystin-2-like protein 2 (Polycystin-2L2) (Polycystic kidney disease 2-like 2 protein) (Polycystin-L2)	PKD2L2	Homo sapiens (Human)	624	FUNCTION: May function as a subunit of a cation channel and play a role in fertilization.		detection of mechanical stimulus [GO:0050982]	membrane [GO:0016020]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]	membrane [GO:0016020]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; detection of mechanical stimulus [GO:0050982]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NZN1	reviewed	IRPL1_HUMAN	Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (EC 3.2.2.6) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1)	IL1RAPL1 OPHN4	Homo sapiens (Human)	696	FUNCTION: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:12783849). May activate the MAP kinase JNK (PubMed:15123616). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). {ECO:0000250|UniProtKB:P59823, ECO:0000250|UniProtKB:P59824, ECO:0000269|PubMed:12783849, ECO:0000269|PubMed:15123616}.		heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of exocytosis [GO:0045920]; neuron differentiation [GO:0030182]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of synapse assembly [GO:0051965]; presynaptic membrane assembly [GO:0097105]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; regulation of presynapse assembly [GO:1905606]; signal transduction [GO:0007165]; trans-synaptic signaling by trans-synaptic complex [GO:0099545]	axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor binding [GO:0005102]	axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor binding [GO:0005102]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of exocytosis [GO:0045920]; neuron differentiation [GO:0030182]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of synapse assembly [GO:0051965]; presynaptic membrane assembly [GO:0097105]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; regulation of presynapse assembly [GO:1905606]; signal transduction [GO:0007165]; trans-synaptic signaling by trans-synaptic complex [GO:0099545]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12783849}; Single-pass type I membrane protein {ECO:0000269|PubMed:12783849}. Cytoplasm {ECO:0000269|PubMed:12783849}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=May localize to the cell body and growth cones of dendrite-like processes. {ECO:0000250}.
Q9NZN3	reviewed	EHD3_HUMAN	EH domain-containing protein 3 (PAST homolog 3)	EHD3 EHD2 PAST3	Homo sapiens (Human)	535	FUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250). {ECO:0000250|UniProtKB:Q9QXY6, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19139087, ECO:0000269|PubMed:21791287, ECO:0000269|PubMed:23781025, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250, ECO:0000305|PubMed:20489164}.		cilium assembly [GO:0060271]; early endosome to Golgi transport [GO:0034498]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; Golgi to lysosome transport [GO:0090160]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor recycling [GO:0001881]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of Golgi organization [GO:1903358]	ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; nucleic acid binding [GO:0003676]	ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; nucleic acid binding [GO:0003676]; cilium assembly [GO:0060271]; early endosome to Golgi transport [GO:0034498]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; Golgi to lysosome transport [GO:0090160]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor recycling [GO:0001881]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of Golgi organization [GO:1903358]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:17233914}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:17233914}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, cilium membrane {ECO:0000269|PubMed:25686250}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with RAB8A and MYO5B to a cytoplasmic tubular network devoid of RAB11A (By similarity). Colocalizes with ANK2 in myocyte perinuclear region (PubMed:20489164). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (By similarity). {ECO:0000250|UniProtKB:Q9QXY6, ECO:0000269|PubMed:20489164, ECO:0000269|PubMed:25686250}.
Q9NZN4	reviewed	EHD2_HUMAN	EH domain-containing protein 2 (PAST homolog 2)	EHD2 PAST2	Homo sapiens (Human)	543	FUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833). {ECO:0000250|UniProtKB:Q8BH64, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:25588833}.		cilium assembly [GO:0060271]; cortical actin cytoskeleton organization [GO:0030866]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; plasma membrane tubulation [GO:0097320]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of myoblast fusion [GO:1901741]; protein localization to plasma membrane [GO:0072659]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; protein domain specific binding [GO:0019904]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; protein domain specific binding [GO:0019904]; cilium assembly [GO:0060271]; cortical actin cytoskeleton organization [GO:0030866]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; plasma membrane tubulation [GO:0097320]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of myoblast fusion [GO:1901741]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17233914}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8BH64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8BH64}. Membrane, caveola {ECO:0000269|PubMed:22323287}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8BH64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8BH64}. Endosome membrane {ECO:0000250|UniProtKB:Q4V8H8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q4V8H8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q4V8H8}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8BH64}. Note=Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes. {ECO:0000250|UniProtKB:Q8BH64}.
Q9NZN5	reviewed	ARHGC_HUMAN	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)	ARHGEF12 KIAA0382 LARG	Homo sapiens (Human)	1544	FUNCTION: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}.		G protein-coupled receptor signaling pathway [GO:0007186]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}. Note=Translocated to the membrane upon stimulation. {ECO:0000305}.
Q9NZN8	reviewed	CNOT2_HUMAN	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2)	CNOT2 CDC36 NOT2 HSPC131 MSTP046	Homo sapiens (Human)	540	FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.	MISCELLANEOUS: [Isoform 3]: May be due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be due to an intron retention. {ECO:0000305}.	negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory ncRNA-mediated gene silencing [GO:0031047]; trophectodermal cell differentiation [GO:0001829]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]	transcription coregulator activity [GO:0003712]; transcription corepressor binding [GO:0001222]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; transcription coregulator activity [GO:0003712]; transcription corepressor binding [GO:0001222]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory ncRNA-mediated gene silencing [GO:0031047]; trophectodermal cell differentiation [GO:0001829]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21299754}. Nucleus {ECO:0000305|PubMed:21299754}.
Q9NZN9	reviewed	AIPL1_HUMAN	Aryl-hydrocarbon-interacting protein-like 1	AIPL1 AIPL2	Homo sapiens (Human)	384	FUNCTION: May be important in protein trafficking and/or protein folding and stabilization.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; phototransduction, visible light [GO:0007603]; protein farnesylation [GO:0018343]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]	farnesylated protein binding [GO:0001918]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; farnesylated protein binding [GO:0001918]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; unfolded protein binding [GO:0051082]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; phototransduction, visible light [GO:0007603]; protein farnesylation [GO:0018343]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12374762}. Nucleus {ECO:0000269|PubMed:12374762}.
Q9NZP6	reviewed	NPAP1_HUMAN	Nuclear pore-associated protein 1	NPAP1 C15orf2	Homo sapiens (Human)	1156	FUNCTION: May be involved in spermatogenesis.		cell differentiation [GO:0030154]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; spermatogenesis [GO:0007283]	intracellular membrane-bounded organelle [GO:0043231]; nuclear inner membrane [GO:0005637]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]	intracellular membrane-bounded organelle [GO:0043231]; nuclear inner membrane [GO:0005637]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]; cell differentiation [GO:0030154]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:22694955}. Nucleus inner membrane {ECO:0000269|PubMed:22694955}. Note=Colocalizes with the NPC and nuclear lamins at the nuclear periphery.
Q9NZP8	reviewed	C1RL_HUMAN	Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21.-) (C1r-like serine protease analog protein) (CLSPa)	C1RL C1RL1 C1RLP CLSPA	Homo sapiens (Human)	487	FUNCTION: Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. {ECO:0000269|PubMed:15358180, ECO:0000269|PubMed:15385675, ECO:0000269|PubMed:15527420}.		complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; zymogen activation [GO:0031638]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; zymogen activation [GO:0031638]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15358180}.
Q9NZQ3	reviewed	SPN90_HUMAN	NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein)	NCKIPSD AF3P21 SPIN90	Homo sapiens (Human)	722	FUNCTION: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}.	MISCELLANEOUS: [Isoform 5]: Found in a brain affected by Alzheimer disease. May be due to intron retention. {ECO:0000305}.	cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; positive regulation of neuron projection development [GO:0010976]	cytosol [GO:0005829]; intermediate filament [GO:0005882]; nucleus [GO:0005634]	Arp2/3 complex binding [GO:0071933]; cytoskeletal protein binding [GO:0008092]; SH3 domain binding [GO:0017124]	cytosol [GO:0005829]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; Arp2/3 complex binding [GO:0071933]; cytoskeletal protein binding [GO:0008092]; SH3 domain binding [GO:0017124]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; positive regulation of neuron projection development [GO:0010976]	SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.
Q9NZQ7	reviewed	PD1L1_HUMAN	Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)	CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1	Homo sapiens (Human)	290	FUNCTION: Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201). {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417, ECO:0000269|PubMed:32929201}.; FUNCTION: The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813417, PubMed:28813410). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity). {ECO:0000250|UniProtKB:Q9EP73, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of tumor necrosis factor superfamily cytokine production [GO:1903556]; negative regulation of type II interferon production [GO:0032689]; positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process [GO:1905404]; positive regulation of cell migration [GO:0030335]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tolerance induction to tumor cell [GO:0002845]; response to cytokine [GO:0034097]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]	actin cytoskeleton [GO:0015629]; early endosome membrane [GO:0031901]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	transcription coactivator activity [GO:0003713]	actin cytoskeleton [GO:0015629]; early endosome membrane [GO:0031901]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; transcription coactivator activity [GO:0003713]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of tumor necrosis factor superfamily cytokine production [GO:1903556]; negative regulation of type II interferon production [GO:0032689]; positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process [GO:1905404]; positive regulation of cell migration [GO:0030335]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tolerance induction to tumor cell [GO:0002845]; response to cytokine [GO:0034097]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:28813417}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:28813417}; Single-pass type I membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:32929201}. Note=Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation (PubMed:28813417). Translocates to the nucleus in response to hypoxia via its interaction with phosphorylated STAT3 (PubMed:32929201). {ECO:0000269|PubMed:28813417, ECO:0000269|PubMed:32929201}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15780196}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Endomembrane system {ECO:0000269|PubMed:15780196}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000269|PubMed:30564891}.
Q9NZQ8	reviewed	TRPM5_HUMAN	Transient receptor potential cation channel subfamily M member 5 (Long transient receptor potential channel 5) (LTrpC-5) (LTrpC5) (MLSN1- and TRP-related gene 1 protein)	TRPM5 LTRPC5 MTR1	Homo sapiens (Human)	1165	FUNCTION: Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals. {ECO:0000269|PubMed:14634208}.		calcium ion transmembrane transport [GO:0070588]; regulation of monoatomic ion transmembrane transport [GO:0034765]	dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	calcium activated cation channel activity [GO:0005227]; ligand-gated calcium channel activity [GO:0099604]; monoatomic ion channel activity [GO:0005216]; potassium channel activity [GO:0005267]; sodium channel activity [GO:0005272]; voltage-gated monoatomic ion channel activity [GO:0005244]	dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; calcium activated cation channel activity [GO:0005227]; ligand-gated calcium channel activity [GO:0099604]; monoatomic ion channel activity [GO:0005216]; potassium channel activity [GO:0005267]; sodium channel activity [GO:0005272]; voltage-gated monoatomic ion channel activity [GO:0005244]; calcium ion transmembrane transport [GO:0070588]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43, ECO:0000255}.
Q9NZR1	reviewed	TMOD2_HUMAN	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)	TMOD2 NTMOD	Homo sapiens (Human)	351	FUNCTION: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; learning or memory [GO:0007611]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; nervous system development [GO:0007399]; neuron-neuron synaptic transmission [GO:0007270]; pointed-end actin filament capping [GO:0051694]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]	cytoskeleton [GO:0005856]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865]; synapse [GO:0045202]	actin binding [GO:0003779]; tropomyosin binding [GO:0005523]	cytoskeleton [GO:0005856]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865]; synapse [GO:0045202]; actin binding [GO:0003779]; tropomyosin binding [GO:0005523]; actin filament organization [GO:0007015]; learning or memory [GO:0007611]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; nervous system development [GO:0007399]; neuron-neuron synaptic transmission [GO:0007270]; pointed-end actin filament capping [GO:0051694]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q9NZR2	reviewed	LRP1B_HUMAN	Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT)	LRP1B LRPDIT	Homo sapiens (Human)	4599	FUNCTION: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.	MISCELLANEOUS: The gene is preferentially inactivated in one histological type of lung cancer (non-small cell lung cancer (NSCLC)). May thus play an important role in tumorigenesis of NSCLCs.	protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]	calcium ion binding [GO:0005509]; low-density lipoprotein particle receptor activity [GO:0005041]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; calcium ion binding [GO:0005509]; low-density lipoprotein particle receptor activity [GO:0005041]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9NZR4	reviewed	VSX1_HUMAN	Visual system homeobox 1 (Homeodomain protein RINX) (Retinal inner nuclear layer homeobox protein) (Transcription factor VSX1)	VSX1 RINX	Homo sapiens (Human)	365	FUNCTION: Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster (PubMed:10903837). May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (PubMed:10903837). Dispensable in early retinal development (By similarity). {ECO:0000250|UniProtKB:Q91V10, ECO:0000269|PubMed:10903837}.	MISCELLANEOUS: [Isoform 1]: Major form.; MISCELLANEOUS: [Isoform 2]: Major form. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Minor form. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Minor form. {ECO:0000305}.	neuron development [GO:0048666]; neuron maturation [GO:0042551]; regulation of DNA-templated transcription [GO:0006355]; response to stimulus [GO:0050896]; retinal bipolar neuron differentiation [GO:0060040]; visual perception [GO:0007601]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; neuron development [GO:0048666]; neuron maturation [GO:0042551]; regulation of DNA-templated transcription [GO:0006355]; response to stimulus [GO:0050896]; retinal bipolar neuron differentiation [GO:0060040]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91V10}.
Q9NZS2	reviewed	KLRF1_HUMAN	Killer cell lectin-like receptor subfamily F member 1 (Lectin-like receptor F1) (Activating coreceptor NKp80) (C-type lectin domain family 5 member C)	KLRF1 CLEC5C ML	Homo sapiens (Human)	231	FUNCTION: Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell surface receptor signaling pathway [GO:0007166]	membrane [GO:0016020]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; MHC class I receptor activity [GO:0032393]; transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; MHC class I receptor activity [GO:0032393]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9NZS9	reviewed	BFAR_HUMAN	Bifunctional apoptosis regulator (RING finger protein 47)	BFAR BAR RNF47	Homo sapiens (Human)	450	FUNCTION: Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. {ECO:0000269|PubMed:14502241}.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	caspase binding [GO:0089720]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; caspase binding [GO:0089720]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10716992, ECO:0000269|PubMed:14502241}; Multi-pass membrane protein {ECO:0000269|PubMed:10716992, ECO:0000269|PubMed:14502241}.
Q9NZT1	reviewed	CALL5_HUMAN	Calmodulin-like protein 5 (Calmodulin-like skin protein)	CALML5 CLSP	Homo sapiens (Human)	146	FUNCTION: Binds calcium. May be involved in terminal differentiation of keratinocytes.		epidermis development [GO:0008544]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]	calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]	extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]; epidermis development [GO:0008544]; signal transduction [GO:0007165]	
Q9NZU0	reviewed	FLRT3_HUMAN	Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3)	FLRT3 KIAA1469 UNQ856/PRO1865	Homo sapiens (Human)	649	FUNCTION: Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity). {ECO:0000250|UniProtKB:B1H234, ECO:0000250|UniProtKB:Q8BGT1, ECO:0000269|PubMed:14706654, ECO:0000269|PubMed:26235030}.		axon guidance [GO:0007411]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; embryonic morphogenesis [GO:0048598]; fibroblast growth factor receptor signaling pathway [GO:0008543]; head development [GO:0060322]; heart development [GO:0007507]; neuron projection development [GO:0031175]; neuron projection extension [GO:1990138]; positive regulation of synapse assembly [GO:0051965]; proepicardium cell migration involved in pericardium morphogenesis [GO:0003345]; response to axon injury [GO:0048678]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560]	axon terminus [GO:0043679]; axonal growth cone [GO:0044295]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone membrane [GO:0032584]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; synaptic membrane [GO:0097060]	chemorepellent activity [GO:0045499]; fibroblast growth factor receptor binding [GO:0005104]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]	axon terminus [GO:0043679]; axonal growth cone [GO:0044295]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone membrane [GO:0032584]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; synaptic membrane [GO:0097060]; chemorepellent activity [GO:0045499]; fibroblast growth factor receptor binding [GO:0005104]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; axon guidance [GO:0007411]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; embryonic morphogenesis [GO:0048598]; fibroblast growth factor receptor signaling pathway [GO:0008543]; head development [GO:0060322]; heart development [GO:0007507]; neuron projection development [GO:0031175]; neuron projection extension [GO:1990138]; positive regulation of synapse assembly [GO:0051965]; proepicardium cell migration involved in pericardium morphogenesis [GO:0003345]; response to axon injury [GO:0048678]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BGT1}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8BGT1}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BGT1}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q8BGT1}. Secreted {ECO:0000250|UniProtKB:Q8BGT1}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BGT1}. Cell projection, growth cone membrane {ECO:0000250|UniProtKB:Q8BGT1}. Note=Detected on dendritic punctae that colocalize in part with glutamaergic synapses, but not with GABAergic synapses. Proteolytic cleavage in the juxtamembrane region gives rise to a shedded ectodomain. {ECO:0000250|UniProtKB:B1H234, ECO:0000250|UniProtKB:Q8BGT1}.
Q9NZU1	reviewed	FLRT1_HUMAN	Leucine-rich repeat transmembrane protein FLRT1 (Fibronectin-like domain-containing leucine-rich transmembrane protein 1)	FLRT1 UNQ752/PRO1483	Homo sapiens (Human)	646	FUNCTION: Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3. {ECO:0000250|UniProtKB:Q6RKD8}.		cell adhesion [GO:0007155]; dendrite development [GO:0016358]; fibroblast growth factor receptor signaling pathway [GO:0008543]; neuron projection extension [GO:1990138]	cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; neuron projection terminus [GO:0044306]; neuronal cell body membrane [GO:0032809]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	protein-macromolecule adaptor activity [GO:0030674]	cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; neuron projection terminus [GO:0044306]; neuronal cell body membrane [GO:0032809]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-macromolecule adaptor activity [GO:0030674]; cell adhesion [GO:0007155]; dendrite development [GO:0016358]; fibroblast growth factor receptor signaling pathway [GO:0008543]; neuron projection extension [GO:1990138]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6RKD8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q6RKD8}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6RKD8}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q6RKD8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6RKD8}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q6RKD8}. Secreted {ECO:0000250|UniProtKB:Q6RKD8}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q6RKD8}. Cell junction {ECO:0000250|UniProtKB:Q6RKD8}. Note=In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles. Detected along neurites and at contacts between neurite termini and other cells. Proteolytic cleavage gives rise to a shedded ectodomain. {ECO:0000250|UniProtKB:Q6RKD8}.
Q9NZU5	reviewed	LMCD1_HUMAN	LIM and cysteine-rich domains protein 1 (Dyxin)	LMCD1	Homo sapiens (Human)	365	FUNCTION: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. {ECO:0000250, ECO:0000269|PubMed:20026769}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; regulation of cardiac muscle hypertrophy [GO:0010611]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; regulation of cardiac muscle hypertrophy [GO:0010611]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=May shuttle between the cytoplasm and the nucleus. {ECO:0000250}.
Q9NZU7	reviewed	CABP1_HUMAN	Calcium-binding protein 1 (CaBP1) (Calbrain) (Caldendrin)	CABP1	Homo sapiens (Human)	370	FUNCTION: Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity). {ECO:0000250|UniProtKB:O88751, ECO:0000250|UniProtKB:Q9JLK7, ECO:0000269|PubMed:11865310, ECO:0000269|PubMed:14570872, ECO:0000269|PubMed:15140941, ECO:0000269|PubMed:15895247, ECO:0000269|PubMed:15980432}.	MISCELLANEOUS: [Isoform Calbrain]: It is currently uncertain whether calbrain represent a spliced isoform. {ECO:0000305}.	negative regulation of protein import into nucleus [GO:0042308]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; enzyme inhibitor activity [GO:0004857]; nuclear localization sequence binding [GO:0008139]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; enzyme inhibitor activity [GO:0004857]; nuclear localization sequence binding [GO:0008139]; negative regulation of protein import into nucleus [GO:0042308]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10625670}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:14685260}. Cell membrane {ECO:0000269|PubMed:10625670, ECO:0000269|PubMed:14570872, ECO:0000269|PubMed:14685260}; Lipid-anchor; Cytoplasmic side. Golgi apparatus {ECO:0000269|PubMed:14570872, ECO:0000269|PubMed:14685260}. Postsynaptic density {ECO:0000305}. Note=L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane. {ECO:0000269|PubMed:10625670}.; SUBCELLULAR LOCATION: [Isoform L-CaBP1]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10625670}. Note=L-CaBP1 is associated most likely with the cytoskeletal structures. {ECO:0000269|PubMed:10625670}.; SUBCELLULAR LOCATION: [Isoform S-CaBP1]: Cytoplasm, cell cortex. Cell membrane {ECO:0000305|PubMed:10625670}; Lipid-anchor {ECO:0000305}. Note=S-CaBP1 is localized at or near the plasma membrane.
Q9NZV1	reviewed	CRIM1_HUMAN	Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein]	CRIM1 S52 UNQ1886/PRO4330	Homo sapiens (Human)	1036	FUNCTION: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. {ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}.		negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoblast differentiation [GO:0045668]; nervous system development [GO:0007399]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	insulin-like growth factor receptor activity [GO:0005010]; PDZ domain binding [GO:0030165]; serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; insulin-like growth factor receptor activity [GO:0005010]; PDZ domain binding [GO:0030165]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoblast differentiation [GO:0045668]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: [Processed cysteine-rich motor neuron 1 protein]: Secreted.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12805376}; Single-pass type I membrane protein {ECO:0000269|PubMed:12805376}.
Q9NZV5	reviewed	SELN_HUMAN	Selenoprotein N (SelN)	SELENON SELN SEPN1	Homo sapiens (Human)	590	FUNCTION: [Isoform 2]: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863). {ECO:0000269|PubMed:18713863, ECO:0000269|PubMed:19557870, ECO:0000269|PubMed:25452428}.; FUNCTION: Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290). {ECO:0000269|PubMed:21131290}.	MISCELLANEOUS: [Isoform 1]: The UGA codons present in position 127 and 462 are either a selenocysteine or a real stop codon.; MISCELLANEOUS: [Isoform 2]: The UGA codon present in position 428 is either a selenocysteine or a real stop codon. {ECO:0000305}.	calcium ion homeostasis [GO:0055074]; cellular response to caffeine [GO:0071313]; cellular response to oxidative stress [GO:0034599]; lung alveolus development [GO:0048286]; mitochondrion organization [GO:0007005]; multicellular organismal response to stress [GO:0033555]; positive regulation of response to oxidative stress [GO:1902884]; positive regulation of skeletal muscle cell proliferation [GO:0014858]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; respiratory system process [GO:0003016]; response to muscle activity involved in regulation of muscle adaptation [GO:0014873]; skeletal muscle fiber development [GO:0048741]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]	endoplasmic reticulum membrane [GO:0005789]	calcium ion binding [GO:0005509]; oxidoreductase activity [GO:0016491]	endoplasmic reticulum membrane [GO:0005789]; calcium ion binding [GO:0005509]; oxidoreductase activity [GO:0016491]; calcium ion homeostasis [GO:0055074]; cellular response to caffeine [GO:0071313]; cellular response to oxidative stress [GO:0034599]; lung alveolus development [GO:0048286]; mitochondrion organization [GO:0007005]; multicellular organismal response to stress [GO:0033555]; positive regulation of response to oxidative stress [GO:1902884]; positive regulation of skeletal muscle cell proliferation [GO:0014858]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; respiratory system process [GO:0003016]; response to muscle activity involved in regulation of muscle adaptation [GO:0014873]; skeletal muscle fiber development [GO:0048741]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]	SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12700173}.
Q9NZV6	reviewed	MSRB1_HUMAN	Methionine-R-sulfoxide reductase B1 (MsrB1) (EC 1.8.4.12) (EC 1.8.4.14) (Selenoprotein X) (SelX)	MSRB1 SEPX1 HSPC270	Homo sapiens (Human)	116	FUNCTION: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. {ECO:0000250|UniProtKB:Q9JLC3}.		actin filament polymerization [GO:0030041]; innate immune response [GO:0045087]; protein repair [GO:0030091]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; nucleus [GO:0005634]	actin binding [GO:0003779]; L-methionine-(R)-S-oxide reductase activity [GO:0033745]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; zinc ion binding [GO:0008270]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; nucleus [GO:0005634]; actin binding [GO:0003779]; L-methionine-(R)-S-oxide reductase activity [GO:0033745]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; zinc ion binding [GO:0008270]; actin filament polymerization [GO:0030041]; innate immune response [GO:0045087]; protein repair [GO:0030091]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9JLC3}. Nucleus {ECO:0000250|UniProtKB:Q9JLC3}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9JLC3}.
Q9NZV7	reviewed	ZIM2_HUMAN	Zinc finger imprinted 2 (Zinc finger protein 656)	ZIM2 ZNF656	Homo sapiens (Human)	527	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NZV8	reviewed	KCND2_HUMAN	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2)	KCND2 KIAA1044	Homo sapiens (Human)	630	FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity). {ECO:0000250|UniProtKB:Q63881, ECO:0000250|UniProtKB:Q9Z0V2, ECO:0000269|PubMed:10551270, ECO:0000269|PubMed:10729221, ECO:0000269|PubMed:11507158, ECO:0000269|PubMed:14623880, ECO:0000269|PubMed:14695263, ECO:0000269|PubMed:14980201, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:16934482, ECO:0000269|PubMed:19171772, ECO:0000269|PubMed:24501278, ECO:0000269|PubMed:24811166}.	MISCELLANEOUS: The transient neuronal A-type potassium current called I(SA) is triggered at membrane potentials that are below the threshold for action potentials. It inactivates rapidly and recovers rapidly from inactivation. It regulates the firing of action potentials and plays a role in synaptic integration and plasticity. Potassium channels containing KCND2 account for about 80% of the neuronal A-type potassium current. In contrast, the potassium channel responsible for the cardiac I(to) current differs between species; it is mediated by KCND2 in rodents. In human and other non-rodents KCND3 may play an equivalent role. {ECO:0000269|PubMed:10551270, ECO:0000305|PubMed:17917103, ECO:0000305|PubMed:18357523}.; MISCELLANEOUS: Is specifically and reversibly inhibited by the scorpion toxin Ts8 (AC P69940). {ECO:0000250|UniProtKB:Q63881}.	action potential [GO:0001508]; cellular response to hypoxia [GO:0071456]; chemical synaptic transmission [GO:0007268]; locomotor rhythm [GO:0045475]; membrane repolarization [GO:0086009]; muscle contraction [GO:0006936]; neuronal action potential [GO:0019228]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of heart contraction [GO:0008016]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sensory perception of pain [GO:0019233]	anchoring junction [GO:0070161]; dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Kv4.2-KChIP2 channel complex [GO:0071193]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; voltage-gated potassium channel complex [GO:0008076]	A-type (transient outward) potassium channel activity [GO:0005250]; metal ion binding [GO:0046872]; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1905030]; voltage-gated potassium channel activity [GO:0005249]	anchoring junction [GO:0070161]; dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Kv4.2-KChIP2 channel complex [GO:0071193]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; voltage-gated potassium channel complex [GO:0008076]; A-type (transient outward) potassium channel activity [GO:0005250]; metal ion binding [GO:0046872]; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1905030]; voltage-gated potassium channel activity [GO:0005249]; action potential [GO:0001508]; cellular response to hypoxia [GO:0071456]; chemical synaptic transmission [GO:0007268]; locomotor rhythm [GO:0045475]; membrane repolarization [GO:0086009]; muscle contraction [GO:0006936]; neuronal action potential [GO:0019228]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of heart contraction [GO:0008016]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sensory perception of pain [GO:0019233]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11102480, ECO:0000269|PubMed:11507158, ECO:0000269|PubMed:14623880, ECO:0000269|PubMed:14695263, ECO:0000269|PubMed:14980201, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:16934482, ECO:0000269|PubMed:19171772, ECO:0000269|PubMed:24501278, ECO:0000269|PubMed:24811166}; Multi-pass membrane protein {ECO:0000269|PubMed:11102480, ECO:0000269|PubMed:14980201, ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:11102480}. Synapse {ECO:0000250|UniProtKB:Q63881}. Perikaryon {ECO:0000250|UniProtKB:Q63881}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q63881}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q63881}. Cell junction {ECO:0000250|UniProtKB:Q63881}. Note=In neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons. Localized preferentially at the dendrites of pyramidal cells in the hippocampus CA1 layer. Detected at GABAergic synapses. Detected at cell junctions that are distinct from synaptic cell contacts. Detected in lipid rafts. Detected primarily at the endoplasmic reticulum or Golgi when expressed by itself (PubMed:15454437). Interaction with KCNIP1, KCNIP2, KCNIP3 or KCNIP4 promotes expression at the cell membrane (PubMed:15454437, PubMed:24811166). Interaction with DPP6 or DPP10 promotes expression at the cell membrane (By similarity). Internalized from the cell membrane by clathrin-dependent endocytosis in response to activation of AMPA-selective glutamate receptors and PKA-mediated phosphorylation at Ser-552. Redistributed from dendritic spines to the main dendritic shaft in response to activation of AMPA-selective glutamate receptors and activation of PKA (By similarity). {ECO:0000250|UniProtKB:Q63881, ECO:0000250|UniProtKB:Q9Z0V2, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:24811166}.
Q9NZW4	reviewed	DSPP_HUMAN	Dentin sialophosphoprotein [Cleaved into: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)]	DSPP	Homo sapiens (Human)	1301	FUNCTION: DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.		biomineral tissue development [GO:0031214]; dentinogenesis [GO:0097187]; odontoblast differentiation [GO:0071895]; regulation of odontoblast differentiation [GO:1901329]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; biomineral tissue development [GO:0031214]; dentinogenesis [GO:0097187]; odontoblast differentiation [GO:0071895]; regulation of odontoblast differentiation [GO:1901329]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q9NZZ3	reviewed	CHMP5_HUMAN	Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60)	CHMP5 C9orf83 SNF7DC2 CGI-34 HSPC177 PNAS-114 PNAS-2	Homo sapiens (Human)	219	FUNCTION: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses) (PubMed:14519844). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release (PubMed:14519844). {ECO:0000269|PubMed:14519844}.		autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; regulation of receptor recycling [GO:0001919]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding [GO:0046755]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; regulation of receptor recycling [GO:0001919]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding [GO:0046755]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15644320}. Endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Midbody {ECO:0000269|PubMed:17853893}. Note=Localizes to the midbody of dividing cells (PubMed:17853893). Localized in two distinct rings on either side of the Flemming body (PubMed:17853893). {ECO:0000269|PubMed:17853893}.
Q9P000	reviewed	COMD9_HUMAN	COMM domain-containing protein 9	COMMD9 HSPC166	Homo sapiens (Human)	198	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:23637203, ECO:0000305|PubMed:21778237}.		cholesterol homeostasis [GO:0042632]; sodium ion transport [GO:0006814]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774]		cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774]; cholesterol homeostasis [GO:0042632]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21778237}. Cytoplasmic vesicle {ECO:0000269|PubMed:21778237}.
Q9P003	reviewed	CNIH4_HUMAN	Protein cornichon homolog 4 (CNIH-4) (Cornichon family AMPA receptor auxiliary protein 4)	CNIH4 HSPC163	Homo sapiens (Human)	139	FUNCTION: Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750). {ECO:0000269|PubMed:24405750}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]	CCR5 chemokine receptor binding [GO:0031730]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; CCR5 chemokine receptor binding [GO:0031730]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:24405750}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:24405750}.
Q9P013	reviewed	CWC15_HUMAN	Spliceosome-associated protein CWC15 homolog	CWC15 C11orf5 AD-002 HSPC148	Homo sapiens (Human)	229	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:33509932}.		mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]; RNA binding [GO:0003723]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
Q9P021	reviewed	CRIPT_HUMAN	Cysteine-rich PDZ-binding protein (Cysteine-rich interactor of PDZ three) (Cysteine-rich interactor of PDZ3)	CRIPT HSPC139	Homo sapiens (Human)	101	FUNCTION: As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity). {ECO:0000250|UniProtKB:Q792Q4, ECO:0000305|PubMed:33509932}.		cytoplasmic microtubule organization [GO:0031122]; establishment of protein localization [GO:0045184]; mRNA processing [GO:0006397]; protein localization to microtubule [GO:0035372]; regulation of postsynaptic density assembly [GO:0099151]; regulation of postsynaptic density protein 95 clustering [GO:1902897]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; spliceosomal complex [GO:0005681]	microtubule binding [GO:0008017]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; spliceosomal complex [GO:0005681]; microtubule binding [GO:0008017]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; cytoplasmic microtubule organization [GO:0031122]; establishment of protein localization [GO:0045184]; mRNA processing [GO:0006397]; protein localization to microtubule [GO:0035372]; regulation of postsynaptic density assembly [GO:0099151]; regulation of postsynaptic density protein 95 clustering [GO:1902897]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Synapse {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Colocalizes with DLG4 in asymmetric synapses. {ECO:0000250}.
Q9P032	reviewed	NDUF4_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa)	NDUFAF4 C6orf66 HRPAP20 HSPC125 My013	Homo sapiens (Human)	175	FUNCTION: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:18179882, PubMed:28853723). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion. {ECO:0000269|PubMed:14871833, ECO:0000269|PubMed:17001319, ECO:0000269|PubMed:18179882, ECO:0000269|PubMed:28853723}.		defense response to virus [GO:0051607]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	calmodulin binding [GO:0005516]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; calmodulin binding [GO:0005516]; defense response to virus [GO:0051607]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18179882}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Q9P035	reviewed	HACD3_HUMAN	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 3) (HACD3) (Butyrate-induced protein 1) (B-ind1) (hB-ind1) (Protein-tyrosine phosphatase-like A domain-containing protein 1)	HACD3 BIND1 PTPLAD1	Homo sapiens (Human)	362	FUNCTION: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10747961, ECO:0000269|PubMed:18554506, ECO:0000269|PubMed:25687571}.		canonical NF-kappaB signal transduction [GO:0007249]; fatty acid elongation [GO:0030497]; JNK cascade [GO:0007254]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of viral genome replication [GO:0045070]; Rac protein signal transduction [GO:0016601]; Rho protein signal transduction [GO:0007266]; small GTPase mediated signal transduction [GO:0007264]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; nuclear membrane [GO:0031965]	3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; nuclear membrane [GO:0031965]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; canonical NF-kappaB signal transduction [GO:0007249]; fatty acid elongation [GO:0030497]; JNK cascade [GO:0007254]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of viral genome replication [GO:0045070]; Rac protein signal transduction [GO:0016601]; Rho protein signal transduction [GO:0007266]; small GTPase mediated signal transduction [GO:0007264]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}.
Q9P055	reviewed	JKAMP_HUMAN	JNK1/MAPK8-associated membrane protein (JKAMP) (JNK1-associated membrane protein) (JAMP) (Medulloblastoma antigen MU-MB-50.4)	JKAMP C14orf100 JAMP CDA06 HSPC213 HSPC327	Homo sapiens (Human)	311	FUNCTION: Regulates the duration of MAPK8 activity in response to various stress stimuli (By similarity). Facilitates degradation of misfolded endoplasmic reticulum (ER) proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (PubMed:18784250). {ECO:0000250|UniProtKB:Q8BI36, ECO:0000269|PubMed:18784250}.	MISCELLANEOUS: Elevated expression in medulloblastomas (PubMed:12800201). Patients with cancer had 2 to 12-fold higher frequencies of antibodies against this antigen (PubMed:12800201). {ECO:0000269|PubMed:12800201}.	response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum membrane [GO:0005789]	ubiquitin protein ligase binding [GO:0031625]	endoplasmic reticulum membrane [GO:0005789]; ubiquitin protein ligase binding [GO:0031625]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18784250}; Multi-pass membrane protein {ECO:0000255}.
Q9P086	reviewed	MED11_HUMAN	Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11)	MED11 HSPC296	Homo sapiens (Human)	117	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.		positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; RNA polymerase II preinitiation complex assembly [GO:0051123]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9P0B6	reviewed	CC167_HUMAN	Coiled-coil domain-containing protein 167	CCDC167 C6orf129 HSPC265	Homo sapiens (Human)	97				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9P0G3	reviewed	KLK14_HUMAN	Kallikrein-14 (hK14) (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6)	KLK14 KLKL6	Homo sapiens (Human)	267	FUNCTION: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. {ECO:0000269|PubMed:15654974, ECO:0000269|PubMed:16885167, ECO:0000269|PubMed:17158887, ECO:0000269|PubMed:17625593, ECO:0000269|PubMed:18056261, ECO:0000269|PubMed:18482984}.		epidermis morphogenesis [GO:0048730]; fertilization [GO:0009566]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; proteolysis [GO:0006508]; seminal clot liquefaction [GO:0070684]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]; epidermis morphogenesis [GO:0048730]; fertilization [GO:0009566]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; proteolysis [GO:0006508]; seminal clot liquefaction [GO:0070684]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:15654974, ECO:0000269|PubMed:16456535, ECO:0000269|PubMed:17110383}.
Q9P0I2	reviewed	EMC3_HUMAN	ER membrane protein complex subunit 3 (Transmembrane protein 111)	EMC3 TMEM111	Homo sapiens (Human)	261	FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305}.		protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]		EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Multi-pass membrane protein {ECO:0000269|PubMed:32439656}.
Q9P0J0	reviewed	NDUAD_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Cell death regulatory protein GRIM-19) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic and interferon-induced mortality 19 protein) (GRIM-19) (Gene associated with retinoic and IFN-induced mortality 19 protein) (NADH-ubiquinone oxidoreductase B16.6 subunit)	NDUFA13 GRIM19 CDA016 CGI-39	Homo sapiens (Human)	144	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:12867595, ECO:0000269|PubMed:15753091, ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; apoptotic signaling pathway [GO:0097190]; cellular response to interferon-beta [GO:0035458]; cellular response to retinoic acid [GO:0071300]; extrinsic apoptotic signaling pathway [GO:0097191]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of peptidase activity [GO:0010952]; positive regulation of protein catabolic process [GO:0045732]; protein insertion into mitochondrial inner membrane [GO:0045039]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; aerobic respiration [GO:0009060]; apoptotic signaling pathway [GO:0097190]; cellular response to interferon-beta [GO:0035458]; cellular response to retinoic acid [GO:0071300]; extrinsic apoptotic signaling pathway [GO:0097191]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of peptidase activity [GO:0010952]; positive regulation of protein catabolic process [GO:0045732]; protein insertion into mitochondrial inner membrane [GO:0045039]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:15059901, ECO:0000269|PubMed:15367666}; Single-pass membrane protein {ECO:0000255}; Matrix side. Nucleus {ECO:0000269|PubMed:12628925}. Note=Localizes mainly in the mitochondrion (PubMed:12628925). May be translocated into the nucleus upon IFN/RA treatment. {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:15059901}.
Q9P0J1	reviewed	PDP1_HUMAN	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1) (PDPC 1)	PDP1 PDP PPM2C	Homo sapiens (Human)	537	FUNCTION: Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. {ECO:0000250}.		peptidyl-threonine dephosphorylation [GO:0035970]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase (lipoamide) phosphatase complex [GO:0045253]	[pyruvate dehydrogenase (lipoamide)] phosphatase activity [GO:0004741]; [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity [GO:0019909]; metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase (lipoamide) phosphatase complex [GO:0045253]; [pyruvate dehydrogenase (lipoamide)] phosphatase activity [GO:0004741]; [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity [GO:0019909]; metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722]; peptidyl-threonine dephosphorylation [GO:0035970]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
Q9P0J7	reviewed	KCMF1_HUMAN	E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (RING-type E3 ubiquitin transferase KCMF1) (ZZ-type zinc finger-containing protein 1)	KCMF1 FIGC ZZZ1	Homo sapiens (Human)	381	FUNCTION: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. {ECO:0000269|PubMed:15581609}.		synaptic signaling [GO:0099536]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]; synapse [GO:0045202]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]; synapse [GO:0045202]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; synaptic signaling [GO:0099536]	
Q9P0K1	reviewed	ADA22_HUMAN	Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2)	ADAM22 MDC2	Homo sapiens (Human)	906	FUNCTION: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. {ECO:0000269|PubMed:12589811, ECO:0000269|PubMed:15882968, ECO:0000269|PubMed:16385342, ECO:0000269|PubMed:19692335}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; negative regulation of cell adhesion [GO:0007162]; proteolysis [GO:0006508]	axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]	axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; negative regulation of cell adhesion [GO:0007162]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27066583}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1V6}.
Q9P0K7	reviewed	RAI14_HUMAN	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)	RAI14 KIAA1334 NORPEG	Homo sapiens (Human)	980	FUNCTION: Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]	actin binding [GO:0003779]	anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; actin binding [GO:0003779]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305|PubMed:11042181, ECO:0000305|PubMed:16729964}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q9EP71}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q5U312}. Cell junction {ECO:0000250|UniProtKB:Q5U312}. Nucleus {ECO:0000269|PubMed:16729964}. Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites (By similarity). Highly expressed at the ectoplasmic specialization, an actin-rich cell junction specific to the testis (By similarity). Predominantly nuclear in nonconfluent cells (PubMed:16729964). {ECO:0000250|UniProtKB:Q5U312, ECO:0000269|PubMed:16729964}.
Q9P0K8	reviewed	FOXJ2_HUMAN	Forkhead box protein J2 (Fork head homologous X)	FOXJ2 FHX	Homo sapiens (Human)	574	FUNCTION: [Isoform FOXJ2.L]: Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q9ES18, ECO:0000269|PubMed:10777590, ECO:0000269|PubMed:10966786}.; FUNCTION: [Isoform FOXJ2.S]: Transcriptional activator. {ECO:0000269|PubMed:10966786}.		cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell differentiation [GO:0110059]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell differentiation [GO:0110059]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus.
Q9P0K9	reviewed	FRS1L_HUMAN	DOMON domain-containing protein FRRS1L (Brain protein CG-6) (Ferric-chelate reductase 1-like protein)	FRRS1L C9orf4	Homo sapiens (Human)	293	FUNCTION: Important modulator of glutamate signaling pathway. {ECO:0000269|PubMed:27236917}.		regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of glutamate receptor signaling pathway [GO:1900449]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of synaptic transmission, glutamatergic [GO:0051966]	plasma membrane [GO:0005886]; synapse [GO:0045202]	dynein intermediate chain binding [GO:0045505]; protein-containing complex binding [GO:0044877]	plasma membrane [GO:0005886]; synapse [GO:0045202]; dynein intermediate chain binding [GO:0045505]; protein-containing complex binding [GO:0044877]; regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of glutamate receptor signaling pathway [GO:1900449]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of synaptic transmission, glutamatergic [GO:0051966]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:B1AXV0}. Synapse {ECO:0000250|UniProtKB:B1AXV0}.
Q9P0L0	reviewed	VAPA_HUMAN	Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33)	VAPA VAP33	Homo sapiens (Human)	249	FUNCTION: Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and late endosomes via interaction with STARD3 (PubMed:33124732). In addition, mediates recruitment of VAPA to plasma membrane sites through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:33124732}.		ceramide transport [GO:0035627]; cholesterol transport [GO:0030301]; COPII-coated vesicle budding [GO:0090114]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; membrane fusion [GO:0061025]; negative regulation by host of viral genome replication [GO:0044828]; neuron projection development [GO:0031175]; phospholipid transport [GO:0015914]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein localization to endoplasmic reticulum [GO:0070972]; sphingomyelin biosynthetic process [GO:0006686]; sterol transport [GO:0015918]; viral release from host cell [GO:0019076]	azurophil granule membrane [GO:0035577]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; microtubule cytoskeleton [GO:0015630]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	cadherin binding [GO:0045296]; FFAT motif binding [GO:0033149]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	azurophil granule membrane [GO:0035577]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; microtubule cytoskeleton [GO:0015630]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; FFAT motif binding [GO:0033149]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; ceramide transport [GO:0035627]; cholesterol transport [GO:0030301]; COPII-coated vesicle budding [GO:0090114]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; membrane fusion [GO:0061025]; negative regulation by host of viral genome replication [GO:0044828]; neuron projection development [GO:0031175]; phospholipid transport [GO:0015914]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein localization to endoplasmic reticulum [GO:0070972]; sphingomyelin biosynthetic process [GO:0006686]; sterol transport [GO:0015918]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10523508, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:30741634, ECO:0000269|PubMed:33124732}; Single-pass type IV membrane protein {ECO:0000269|PubMed:10523508, ECO:0000269|PubMed:19289470}. Cell membrane {ECO:0000269|PubMed:25447204}; Single-pass type IV membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000269|PubMed:10523508}. Nucleus membrane {ECO:0000250|UniProtKB:Q9Z270}. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells. {ECO:0000269|PubMed:10523508}.
Q9P0L1	reviewed	ZKSC7_HUMAN	Zinc finger protein with KRAB and SCAN domains 7 (Zinc finger protein 167) (Zinc finger protein 448) (Zinc finger protein 64)	ZKSCAN7 ZNF167 ZNF448 ZNF64	Homo sapiens (Human)	754	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q9P0L2	reviewed	MARK1_HUMAN	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)	MARK1 KIAA1477 MARK	Homo sapiens (Human)	795	FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}.	MISCELLANEOUS: Phosphorylation of MAPT/tau by MARK1 could play a role in early steps of Alzheimer disease. Pathological aggregation of MAPT/tau to neurofibrillary tangles, filamentous structures consisting of paired helical filaments (PHFs), is one of the hallmarks of Alzheimer disease. Hyperphosphorylation by MARK1 could be the initial step for this abnormal aggregation of tau in Alzheimer disease and animal models of tauopathy (PubMed:11089574). {ECO:0000305|PubMed:11089574}.	cytoskeleton organization [GO:0007010]; establishment of mitochondrion localization [GO:0051654]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of gene expression [GO:0010629]; neuron migration [GO:0001764]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of gene expression [GO:0010628]; protein phosphorylation [GO:0006468]; regulation of dendrite development [GO:0050773]; regulation of neuron projection development [GO:0010975]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; cytoskeleton organization [GO:0007010]; establishment of mitochondrion localization [GO:0051654]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of gene expression [GO:0010629]; neuron migration [GO:0001764]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of gene expression [GO:0010628]; protein phosphorylation [GO:0006468]; regulation of dendrite development [GO:0050773]; regulation of neuron projection development [GO:0010975]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:21145462}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:23666762}. Cell projection, dendrite {ECO:0000269|PubMed:23666762}. Note=Appears to localize to an intracellular network. {ECO:0000250}.
Q9P0L9	reviewed	PK2L1_HUMAN	Polycystin-2-like protein 1 (Polycystin-2L1) (Polycystic kidney disease 2-like 1 protein) (Polycystin-2 homolog) (Polycystin-L) (Polycystin-L1)	PKD2L1 PKD2L PKDL TRPP3	Homo sapiens (Human)	805	FUNCTION: Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:23212381, PubMed:30004384). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration (PubMed:24336289). The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells (PubMed:19812697). The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again (PubMed:23212381). May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity). {ECO:0000250|UniProtKB:A2A259, ECO:0000269|PubMed:10517637, ECO:0000269|PubMed:11959145, ECO:0000269|PubMed:19812697, ECO:0000269|PubMed:23212381, ECO:0000269|PubMed:24336289, ECO:0000269|PubMed:25820328, ECO:0000269|PubMed:27754867, ECO:0000269|PubMed:29425510, ECO:0000269|PubMed:30004384}.	MISCELLANEOUS: [Isoform 4]: Unusual intron exon spliced junction. {ECO:0000305}.	cellular response to acidic pH [GO:0071468]; detection of chemical stimulus involved in sensory perception of sour taste [GO:0001581]; detection of chemical stimulus involved in sensory perception of taste [GO:0050912]; detection of mechanical stimulus [GO:0050982]; inorganic cation transmembrane transport [GO:0098662]; monoatomic cation transport [GO:0006812]; potassium ion transmembrane transport [GO:0071805]; protein homotetramerization [GO:0051289]; response to water [GO:0009415]; sensory perception of sour taste [GO:0050915]; smoothened signaling pathway [GO:0007224]; sodium ion transmembrane transport [GO:0035725]	actin cytoskeleton [GO:0015629]; calcium channel complex [GO:0034704]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	alpha-actinin binding [GO:0051393]; calcium activated cation channel activity [GO:0005227]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-activated potassium channel activity [GO:0015269]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; sodium channel activity [GO:0005272]; sour taste receptor activity [GO:0033040]; transmembrane transporter binding [GO:0044325]	actin cytoskeleton [GO:0015629]; calcium channel complex [GO:0034704]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; alpha-actinin binding [GO:0051393]; calcium activated cation channel activity [GO:0005227]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-activated potassium channel activity [GO:0015269]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; sodium channel activity [GO:0005272]; sour taste receptor activity [GO:0033040]; transmembrane transporter binding [GO:0044325]; cellular response to acidic pH [GO:0071468]; detection of chemical stimulus involved in sensory perception of sour taste [GO:0001581]; detection of chemical stimulus involved in sensory perception of taste [GO:0050912]; detection of mechanical stimulus [GO:0050982]; inorganic cation transmembrane transport [GO:0098662]; monoatomic cation transport [GO:0006812]; potassium ion transmembrane transport [GO:0071805]; protein homotetramerization [GO:0051289]; response to water [GO:0009415]; sensory perception of sour taste [GO:0050915]; smoothened signaling pathway [GO:0007224]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:24336289}; Multi-pass membrane protein {ECO:0000269|PubMed:30004384}. Cell membrane {ECO:0000269|PubMed:10517637, ECO:0000269|PubMed:11959145, ECO:0000269|PubMed:23212381, ECO:0000269|PubMed:25820328, ECO:0000269|PubMed:27754867, ECO:0000269|PubMed:29425510}; Multi-pass membrane protein {ECO:0000269|PubMed:30004384}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:A2A259}. Note=Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane. {ECO:0000250|UniProtKB:A2A259}.
Q9P0M2	reviewed	AKA7G_HUMAN	A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma)	AKAP7 AKAP18	Homo sapiens (Human)	348	FUNCTION: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. {ECO:0000269|PubMed:10613906, ECO:0000269|PubMed:17244820}.		modulation of chemical synaptic transmission [GO:0050804]; regulation of protein kinase A signaling [GO:0010738]	cytosol [GO:0005829]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	nucleotide binding [GO:0000166]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase binding [GO:0019901]	cytosol [GO:0005829]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; nucleotide binding [GO:0000166]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase binding [GO:0019901]; modulation of chemical synaptic transmission [GO:0050804]; regulation of protein kinase A signaling [GO:0010738]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:10613906}.
Q9P0M6	reviewed	H2AW_HUMAN	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)	MACROH2A2 H2AFY2	Homo sapiens (Human)	372	FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. {ECO:0000269|PubMed:15621527}.		brain development [GO:0007420]; dosage compensation [GO:0007549]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; nucleosome assembly [GO:0006334]; positive regulation of keratinocyte differentiation [GO:0045618]	Barr body [GO:0001740]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; structural constituent of chromatin [GO:0030527]; transcription cis-regulatory region binding [GO:0000976]	Barr body [GO:0001740]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; structural constituent of chromatin [GO:0030527]; transcription cis-regulatory region binding [GO:0000976]; brain development [GO:0007420]; dosage compensation [GO:0007549]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; nucleosome assembly [GO:0006334]; positive regulation of keratinocyte differentiation [GO:0045618]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11262398, ECO:0000269|PubMed:11331621, ECO:0000269|PubMed:15621527}. Chromosome {ECO:0000269|PubMed:11262398, ECO:0000269|PubMed:11331621, ECO:0000269|PubMed:15621527}. Note=Enriched in inactive X chromosome chromatin (PubMed:11331621, PubMed:11262398) and in senescence-associated heterochromatin (PubMed:15621527). {ECO:0000269|PubMed:11262398, ECO:0000269|PubMed:11331621, ECO:0000269|PubMed:15621527}.
Q9P0N5	reviewed	TM216_HUMAN	Transmembrane protein 216	TMEM216 HSPC244	Homo sapiens (Human)	145	FUNCTION: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. {ECO:0000269|PubMed:22282472}.	MISCELLANEOUS: TMEM138 and TMEM216 genes are adjacent and are aligned in a head-to-tail configuration. They share some cis regulatory region and display coordinated expression. Genes were joined by chromosomal rearrangement at the amphiboan to reptile evolutionary transition around 340 million years ago (PubMed:22282472). {ECO:0000305|PubMed:22282472}.	cilium assembly [GO:0060271]; non-motile cilium assembly [GO:1905515]	ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; MKS complex [GO:0036038]		ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; MKS complex [GO:0036038]; cilium assembly [GO:0060271]; non-motile cilium assembly [GO:1905515]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22282472}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Q9P0N8	reviewed	MARH2_HUMAN	E3 ubiquitin-protein ligase MARCHF2 (EC 2.3.2.27) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II) (RING finger protein 172) (RING-type E3 ubiquitin transferase MARCHF2)	MARCHF2 MARCH2 RNF172 HSPC240	Homo sapiens (Human)	246	FUNCTION: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:14722266, PubMed:16428329). Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Ubiquitinates and therefore mediates the degradation of DLG1 (PubMed:17980554). Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (PubMed:31142615). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (PubMed:32935379). May be involved in endosomal trafficking through interaction with STX6 (PubMed:15689499). {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:15689499, ECO:0000269|PubMed:16428329, ECO:0000269|PubMed:17980554, ECO:0000269|PubMed:23818989, ECO:0000269|PubMed:31142615, ECO:0000269|PubMed:32935379}.; FUNCTION: (Microbial infection) Positively regulates the degradation of Vesicular stomatitis virus (VSV) G protein via the lysosomal degradation pathway (PubMed:29573664). Represses HIV-1 viral production and may inhibit the translocation of HIV-1 env to the cell surface, resulting in decreased viral cell-cell transmission (PubMed:29573664). {ECO:0000269|PubMed:29573664}.		antibacterial innate immune response [GO:0140367]; antiviral innate immune response [GO:0140374]; endocytosis [GO:0006897]; positive regulation of lysosomal protein catabolic process [GO:1905167]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; antibacterial innate immune response [GO:0140367]; antiviral innate immune response [GO:0140374]; endocytosis [GO:0006897]; positive regulation of lysosomal protein catabolic process [GO:1905167]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5I0I2}. Lysosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:23166351}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5I0I2}. Golgi apparatus membrane {ECO:0000269|PubMed:23818989}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:32935379}. Cell membrane {ECO:0000269|PubMed:32935379}; Multi-pass membrane protein {ECO:0000269|PubMed:32935379}.
Q9P0N9	reviewed	TBCD7_HUMAN	TBC1 domain family member 7 (Cell migration-inducing protein 23)	TBC1D7 TBC7 HSPC239	Homo sapiens (Human)	293	FUNCTION: Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:22795129, PubMed:24529379). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:22795129, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:22795129). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:24529379). {ECO:0000269|PubMed:22795129, ECO:0000269|PubMed:24529379}.		activation of GTPase activity [GO:0090630]; cellular response to starvation [GO:0009267]; negative regulation of cilium assembly [GO:1902018]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein ubiquitination [GO:0031398]; response to growth factor [GO:0070848]	ciliary basal body [GO:0036064]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; TSC1-TSC2 complex [GO:0033596]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	ciliary basal body [GO:0036064]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; TSC1-TSC2 complex [GO:0033596]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; activation of GTPase activity [GO:0090630]; cellular response to starvation [GO:0009267]; negative regulation of cilium assembly [GO:1902018]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein ubiquitination [GO:0031398]; response to growth factor [GO:0070848]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:24529379}. Cytoplasmic vesicle {ECO:0000269|PubMed:17658474}. Cytoplasm, cytosol {ECO:0000269|PubMed:24529379}. Note=Localizes in the cytoplasmic vesicles of the endomembrane in association with the TSC-TBC complex (PubMed:17658474). Recruited to lysosomal membranes in a RHEB-dependent process in absence of nutrients (PubMed:24529379). In response to nutrients, the complex dissociates from lysosomal membranes and relocalizes to the cytosol (PubMed:24529379). {ECO:0000269|PubMed:17658474, ECO:0000269|PubMed:24529379}.
Q9P0P0	reviewed	RN181_HUMAN	E3 ubiquitin-protein ligase RNF181 (EC 2.3.2.27) (RING finger protein 181)	RNF181 HSPC238	Homo sapiens (Human)	153	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:18331836). Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1 (PubMed:24811749). {ECO:0000269|PubMed:18331836, ECO:0000269|PubMed:24811749}.		protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	
Q9P0P8	reviewed	MRES1_HUMAN	Mitochondrial transcription rescue factor 1	MTRES1 C6orf203 HSPC230	Homo sapiens (Human)	240	FUNCTION: Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability (PubMed:31226201). Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:33243891, PubMed:31396629). As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891). {ECO:0000269|PubMed:31226201, ECO:0000269|PubMed:31396629, ECO:0000269|PubMed:33243891}.		regulation of mitochondrial transcription [GO:1903108]; rescue of stalled ribosome [GO:0072344]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]; regulation of mitochondrial transcription [GO:1903108]; rescue of stalled ribosome [GO:0072344]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:31226201, ECO:0000269|PubMed:31396629}.
Q9P0R6	reviewed	GSKIP_HUMAN	GSK3B-interacting protein (GSKIP) (GSK3beta interaction protein)	GSKIP C14orf129 HSPC210	Homo sapiens (Human)	139	FUNCTION: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:27484798, PubMed:25920809, PubMed:16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:27484798, PubMed:16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702). {ECO:0000269|PubMed:16981698, ECO:0000269|PubMed:19830702, ECO:0000269|PubMed:25920809, ECO:0000269|PubMed:27484798}.		intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of Wnt signaling pathway [GO:0030111]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	kinase regulator activity [GO:0019207]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; kinase regulator activity [GO:0019207]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of Wnt signaling pathway [GO:0030111]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16981698, ECO:0000269|PubMed:20007971}. Nucleus {ECO:0000269|PubMed:20007971}.
Q9P0S3	reviewed	ORML1_HUMAN	ORM1-like protein 1 (Adoplin-1)	ORMDL1 HSPC202	Homo sapiens (Human)	153	FUNCTION: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8N138, ECO:0000269|PubMed:20182505}.		ceramide metabolic process [GO:0006672]; intracellular sphingolipid homeostasis [GO:0090156]; motor behavior [GO:0061744]; myelination [GO:0042552]; negative regulation of ceramide biosynthetic process [GO:1900060]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SPOTS complex [GO:0035339]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SPOTS complex [GO:0035339]; ceramide metabolic process [GO:0006672]; intracellular sphingolipid homeostasis [GO:0090156]; motor behavior [GO:0061744]; myelination [GO:0042552]; negative regulation of ceramide biosynthetic process [GO:1900060]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12093374}; Multi-pass membrane protein {ECO:0000269|PubMed:12093374}.
Q9P0S9	reviewed	TM14C_HUMAN	Transmembrane protein 14C	TMEM14C C6orf53 HSPC194	Homo sapiens (Human)	112	FUNCTION: Required for normal heme biosynthesis. {ECO:0000250}.		erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; mitochondrial transport [GO:0006839]; nitrogen compound transport [GO:0071705]; organic substance transport [GO:0071702]; regulation of heme biosynthetic process [GO:0070453]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]		mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; mitochondrial transport [GO:0006839]; nitrogen compound transport [GO:0071705]; organic substance transport [GO:0071702]; regulation of heme biosynthetic process [GO:0070453]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9P0T4	reviewed	ZN581_HUMAN	Zinc finger protein 581	ZNF581 HSPC189	Homo sapiens (Human)	197	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9P0T7	reviewed	TMEM9_HUMAN	Proton-transporting V-type ATPase complex assembly regulator TMEM9 (v-ATPase assembly regulator TMEM9) (Dermal papilla-derived protein 4) (Transmembrane protein 9) (Protein TMEM9)	TMEM9 DERP4 TMEM9A HSPC186 PSEC0012 UNQ631/PRO1248	Homo sapiens (Human)	183	FUNCTION: Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (PubMed:30374053). By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (PubMed:30374053). TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568). In the liver, involved in hepatic regeneration (PubMed:32380568). {ECO:0000269|PubMed:30374053, ECO:0000269|PubMed:32380568}.		endosomal lumen acidification [GO:0048388]; lysosomal lumen acidification [GO:0007042]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein transport [GO:0015031]; proton-transporting V-type ATPase complex assembly [GO:0070070]; regulation of protein catabolic process [GO:0042176]	intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; multivesicular body membrane [GO:0032585]		intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; multivesicular body membrane [GO:0032585]; endosomal lumen acidification [GO:0048388]; lysosomal lumen acidification [GO:0007042]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein transport [GO:0015031]; proton-transporting V-type ATPase complex assembly [GO:0070070]; regulation of protein catabolic process [GO:0042176]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:12359240, ECO:0000305|PubMed:30374053}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:12359240, ECO:0000269|PubMed:30374053}; Single-pass type I membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:30374053}; Single-pass type I membrane protein {ECO:0000255}.
Q9P0U1	reviewed	TOM7_HUMAN	Mitochondrial import receptor subunit TOM7 homolog (Translocase of outer membrane 7 kDa subunit homolog)	TOMM7 TOM7 TOMM07 AD-014	Homo sapiens (Human)	55	FUNCTION: Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria. {ECO:0000269|PubMed:18331822, ECO:0000269|PubMed:24270810}.		positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; regulation of protein stability [GO:0031647]	mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]	protein transmembrane transporter activity [GO:0008320]	mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; protein transmembrane transporter activity [GO:0008320]; positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:12198123}; Single-pass membrane protein {ECO:0000269|PubMed:12198123}.
Q9P0U3	reviewed	SENP1_HUMAN	Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1)	SENP1	Homo sapiens (Human)	644	FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Deconjugates SUMO1 from METTL3 (PubMed:29506078). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	deSUMOylase activity [GO:0016929]; endopeptidase activity [GO:0004175]; SUMO-specific endopeptidase activity [GO:0070139]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; deSUMOylase activity [GO:0016929]; endopeptidase activity [GO:0004175]; SUMO-specific endopeptidase activity [GO:0070139]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25406032}. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.
Q9P0U4	reviewed	CXXC1_HUMAN	CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)	CXXC1 CFP1 CGBP PCCX1 PHF18	Homo sapiens (Human)	656	FUNCTION: Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}.		positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; methylated histone binding [GO:0035064]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; methylated histone binding [GO:0035064]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:12200428, ECO:0000269|PubMed:17355966}. Nucleus {ECO:0000250|UniProtKB:Q9CWW7}. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes.
Q9P0V3	reviewed	SH3B4_HUMAN	SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein)	SH3BP4 BOG25 EHB10 TTP	Homo sapiens (Human)	963	FUNCTION: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}.	MISCELLANEOUS: Overexpression or depletion of SH3BP4 result in a specific decrease of the transferrin receptor endocytosis that can be rescued by DNM2 overexpression.; MISCELLANEOUS: [Isoform 2]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.	cellular response to amino acid stimulus [GO:0071230]; endocytosis [GO:0006897]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of GTPase activity [GO:0034260]; negative regulation of TOR signaling [GO:0032007]; positive regulation of autophagy [GO:0010508]; protein localization to lysosome [GO:0061462]; regulation of catalytic activity [GO:0050790]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GDP-dissociation inhibitor activity [GO:0005092]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; GDP-dissociation inhibitor activity [GO:0005092]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; cellular response to amino acid stimulus [GO:0071230]; endocytosis [GO:0006897]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of GTPase activity [GO:0034260]; negative regulation of TOR signaling [GO:0032007]; positive regulation of autophagy [GO:0010508]; protein localization to lysosome [GO:0061462]; regulation of catalytic activity [GO:0050790]	SUBCELLULAR LOCATION: Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus {ECO:0000305}. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
Q9P0V8	reviewed	SLAF8_HUMAN	SLAM family member 8 (B-lymphocyte activator macrophage expressed) (BCM-like membrane protein) (CD antigen CD353)	SLAMF8 BLAME	Homo sapiens (Human)	285	FUNCTION: May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. {ECO:0000269|PubMed:11313408}.		B-1 B cell lineage commitment [GO:0002336]; defense response to bacterium [GO:0042742]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; negative regulation of dendritic cell chemotaxis [GO:2000509]; negative regulation of macrophage chemotaxis [GO:0010760]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of neutrophil migration [GO:1902623]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; phagosome acidification [GO:0090383]; regulation of B cell differentiation [GO:0045577]; regulation of kinase activity [GO:0043549]; regulation of NAD(P)H oxidase activity [GO:0033860]	cell surface [GO:0009986]; membrane [GO:0016020]	identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; membrane [GO:0016020]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; B-1 B cell lineage commitment [GO:0002336]; defense response to bacterium [GO:0042742]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; negative regulation of dendritic cell chemotaxis [GO:2000509]; negative regulation of macrophage chemotaxis [GO:0010760]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of neutrophil migration [GO:1902623]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; phagosome acidification [GO:0090383]; regulation of B cell differentiation [GO:0045577]; regulation of kinase activity [GO:0043549]; regulation of NAD(P)H oxidase activity [GO:0033860]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9P0V9	reviewed	SEP10_HUMAN	Septin-10	SEPTIN10 SEPT10	Homo sapiens (Human)	454	FUNCTION: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). {ECO:0000305}.		cytoskeleton-dependent cytokinesis [GO:0061640]	cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; septin complex [GO:0031105]; septin ring [GO:0005940]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]	cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; septin complex [GO:0031105]; septin ring [GO:0005940]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]; cytoskeleton-dependent cytokinesis [GO:0061640]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12711328}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8C650}. Note=Detected in the annulus of the sperm flagellum and in the neck region in spermatids and mature sperm (By similarity). Using a GFP-fusion protein, detected in the nucleus. {ECO:0000250|UniProtKB:Q8C650, ECO:0000269|PubMed:12711328}.
Q9P0W0	reviewed	IFNK_HUMAN	Interferon kappa (IFN-kappa)	IFNK UNQ6124/PRO20084	Homo sapiens (Human)	207	FUNCTION: May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. {ECO:0000269|PubMed:11514542, ECO:0000269|PubMed:12391192}.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of innate immune response [GO:0045089]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; regulation of DNA-templated transcription [GO:0006355]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of innate immune response [GO:0045089]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; regulation of DNA-templated transcription [GO:0006355]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
Q9P0W2	reviewed	HM20B_HUMAN	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein) (BRCA2-associated factor 35) (HMG box-containing protein 20B) (HMG domain-containing protein 2) (HMG domain-containing protein HMGX2) (Sox-like transcriptional factor) (Structural DNA-binding protein BRAF35)	HMG20B BRAF35 HMGX2 HMGXB2 SMARCE1R	Homo sapiens (Human)	317	FUNCTION: Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.		cell cycle [GO:0007049]; chromatin organization [GO:0006325]; negative regulation of protein sumoylation [GO:0033234]; positive regulation of neuron differentiation [GO:0045666]; protein sumoylation [GO:0016925]; regulation of gene expression [GO:0010468]; skeletal muscle cell differentiation [GO:0035914]	chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]	chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; cell cycle [GO:0007049]; chromatin organization [GO:0006325]; negative regulation of protein sumoylation [GO:0033234]; positive regulation of neuron differentiation [GO:0045666]; protein sumoylation [GO:0016925]; regulation of gene expression [GO:0010468]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2.
Q9P0W8	reviewed	SPAT7_HUMAN	Spermatogenesis-associated protein 7 (HSD-3.1) (Spermatogenesis-associated protein HSD3)	SPATA7 HSD3	Homo sapiens (Human)	599	FUNCTION: Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity). {ECO:0000250|UniProtKB:Q80VP2}.		microtubule cytoskeleton organization [GO:0000226]; photoreceptor cell maintenance [GO:0045494]; protein localization to photoreceptor connecting cilium [GO:1903621]; protein localization to photoreceptor outer segment [GO:1903546]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; photoreceptor connecting cilium [GO:0032391]; photoreceptor distal connecting cilium [GO:0120206]; rod photoreceptor outer segment [GO:0120200]		axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; photoreceptor connecting cilium [GO:0032391]; photoreceptor distal connecting cilium [GO:0120206]; rod photoreceptor outer segment [GO:0120200]; microtubule cytoskeleton organization [GO:0000226]; photoreceptor cell maintenance [GO:0045494]; protein localization to photoreceptor connecting cilium [GO:1903621]; protein localization to photoreceptor outer segment [GO:1903546]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:25398945}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:25398945}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25398945}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q80VP2}. Note=Localizes to the microtubule network. {ECO:0000269|PubMed:25398945}.
Q9P0X4	reviewed	CAC1I_HUMAN	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage-gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3)	CACNA1I KIAA1120	Homo sapiens (Human)	2223	FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity). {ECO:0000250}.		calcium ion import across plasma membrane [GO:0098703]; neuronal action potential [GO:0019228]; regulation of monoatomic ion transmembrane transport [GO:0034765]; signal transduction [GO:0007165]; sleep [GO:0030431]	plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]	high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245]	plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245]; calcium ion import across plasma membrane [GO:0098703]; neuronal action potential [GO:0019228]; regulation of monoatomic ion transmembrane transport [GO:0034765]; signal transduction [GO:0007165]; sleep [GO:0030431]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9P0Z9	reviewed	SOX_HUMAN	Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase)	PIPOX LPIPOX PSO	Homo sapiens (Human)	390	FUNCTION: Metabolizes sarcosine and L-pipecolic acid. {ECO:0000269|PubMed:10642506}.		L-lysine catabolic process to acetyl-CoA via L-pipecolate [GO:0033514]; lysine catabolic process [GO:0006554]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	flavin adenine dinucleotide binding [GO:0050660]; L-pipecolate oxidase activity [GO:0050031]; sarcosine oxidase activity [GO:0008115]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; flavin adenine dinucleotide binding [GO:0050660]; L-pipecolate oxidase activity [GO:0050031]; sarcosine oxidase activity [GO:0008115]; L-lysine catabolic process to acetyl-CoA via L-pipecolate [GO:0033514]; lysine catabolic process [GO:0006554]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:10642506}.
Q9P107	reviewed	GMIP_HUMAN	GEM-interacting protein (GMIP)	GMIP	Homo sapiens (Human)	970	FUNCTION: Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}.		intracellular signal transduction [GO:0035556]; negative regulation of GTPase activity [GO:0034260]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; intracellular signal transduction [GO:0035556]; negative regulation of GTPase activity [GO:0034260]; regulation of small GTPase mediated signal transduction [GO:0051056]	
Q9P109	reviewed	GCNT4_HUMAN	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (EC 2.4.1.102) (Core 2-branching enzyme 3) (Core2-GlcNAc-transferase 3) (C2GnT3)	GCNT4	Homo sapiens (Human)	453	FUNCTION: Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity. {ECO:0000269|PubMed:10753916}.		carbohydrate metabolic process [GO:0005975]; inter-male aggressive behavior [GO:0002121]; kidney morphogenesis [GO:0060993]; neutrophil homeostasis [GO:0001780]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; thyroid hormone metabolic process [GO:0042403]; tissue morphogenesis [GO:0048729]	Golgi membrane [GO:0000139]	acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]	Golgi membrane [GO:0000139]; acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]; carbohydrate metabolic process [GO:0005975]; inter-male aggressive behavior [GO:0002121]; kidney morphogenesis [GO:0060993]; neutrophil homeostasis [GO:0001780]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; thyroid hormone metabolic process [GO:0042403]; tissue morphogenesis [GO:0048729]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9P121	reviewed	NTRI_HUMAN	Neurotrimin (hNT) (IgLON family member 2)	NTM IGLON2 NT UNQ297/PRO337	Homo sapiens (Human)	344	FUNCTION: Neural cell adhesion molecule.		cell adhesion [GO:0007155]; neuron recognition [GO:0008038]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell adhesion [GO:0007155]; neuron recognition [GO:0008038]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
Q9P126	reviewed	CLC1B_HUMAN	C-type lectin domain family 1 member B (C-type lectin-like receptor 2) (CLEC-2)	CLEC1B CLEC2 UNQ721/PRO1384	Homo sapiens (Human)	229	FUNCTION: C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485). {ECO:0000269|PubMed:18215137, ECO:0000269|PubMed:18955485}.; FUNCTION: (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485). {ECO:0000269|PubMed:18955485, ECO:0000305|PubMed:16174766}.; FUNCTION: (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507). {ECO:0000305|PubMed:16940507}.		cell surface receptor signaling pathway [GO:0007166]; defense response [GO:0006952]; platelet formation [GO:0030220]; signal transduction [GO:0007165]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; defense response [GO:0006952]; platelet formation [GO:0030220]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9P127	reviewed	LUZP4_HUMAN	Leucine zipper protein 4 (Cancer/testis antigen 28) (CT-28) (CT28) (Tumor antigen HOM-TES-85)	LUZP4	Homo sapiens (Human)	313	FUNCTION: Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA export function in cells compromised by loss of mRNA export adapters (PubMed:25662211). {ECO:0000269|PubMed:25662211}.		mRNA transport [GO:0051028]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA transport [GO:0051028]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12032826, ECO:0000269|PubMed:25662211}. Cytoplasm {ECO:0000269|PubMed:25662211}. Note=In nuclear speckles. Relocalizes to the cytoplasm during cell division. {ECO:0000269|PubMed:12032826, ECO:0000269|PubMed:25662211}.
Q9P1A6	reviewed	DLGP2_HUMAN	Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2)	DLGAP2 C8orf68 DAP2 ERICH1-AS1	Homo sapiens (Human)	1054	FUNCTION: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.		neuron-neuron synaptic transmission [GO:0007270]	glutamatergic synapse [GO:0098978]; neurofilament [GO:0005883]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572]	molecular adaptor activity [GO:0060090]	glutamatergic synapse [GO:0098978]; neurofilament [GO:0005883]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572]; molecular adaptor activity [GO:0060090]; neuron-neuron synaptic transmission [GO:0007270]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.
Q9P1Q0	reviewed	VPS54_HUMAN	Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p)	VPS54 HCC8	Homo sapiens (Human)	977	FUNCTION: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061). {ECO:0000269|PubMed:18367545, ECO:0000269|PubMed:25799061}.		apoptotic DNA fragmentation [GO:0006309]; astrocyte differentiation [GO:0048708]; cellular response to progesterone stimulus [GO:0071393]; gene expression [GO:0010467]; Golgi to vacuole transport [GO:0006896]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; L-glutamate import [GO:0051938]; lysosomal transport [GO:0007041]; microglia differentiation [GO:0014004]; mitochondrion organization [GO:0007005]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; musculoskeletal movement [GO:0050881]; negative regulation of motor neuron apoptotic process [GO:2000672]; neural tissue regeneration [GO:0097719]; neurofilament cytoskeleton organization [GO:0060052]; neuroinflammatory response [GO:0150076]; neuromuscular synaptic transmission [GO:0007274]; neuron projection morphogenesis [GO:0048812]; post-embryonic forelimb morphogenesis [GO:0035128]; protein localization to cell surface [GO:0034394]; protein targeting to ER [GO:0045047]; protein targeting to lysosome [GO:0006622]; regulation of growth [GO:0040008]; respiratory electron transport chain [GO:0022904]; response to antibiotic [GO:0046677]; response to calcium ion [GO:0051592]; retrograde transport, endosome to Golgi [GO:0042147]; skeletal muscle tissue growth [GO:0048630]; spermatid differentiation [GO:0048515]; sphingolipid catabolic process [GO:0030149]; striated muscle contraction [GO:0006941]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]; thrombin-activated receptor signaling pathway [GO:0070493]; ubiquitin recycling [GO:0010992]; vacuole organization [GO:0007033]; vesicle-mediated cholesterol transport [GO:0090119]	cytosol [GO:0005829]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	syntaxin binding [GO:0019905]	cytosol [GO:0005829]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; syntaxin binding [GO:0019905]; apoptotic DNA fragmentation [GO:0006309]; astrocyte differentiation [GO:0048708]; cellular response to progesterone stimulus [GO:0071393]; gene expression [GO:0010467]; Golgi to vacuole transport [GO:0006896]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; L-glutamate import [GO:0051938]; lysosomal transport [GO:0007041]; microglia differentiation [GO:0014004]; mitochondrion organization [GO:0007005]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; musculoskeletal movement [GO:0050881]; negative regulation of motor neuron apoptotic process [GO:2000672]; neural tissue regeneration [GO:0097719]; neurofilament cytoskeleton organization [GO:0060052]; neuroinflammatory response [GO:0150076]; neuromuscular synaptic transmission [GO:0007274]; neuron projection morphogenesis [GO:0048812]; post-embryonic forelimb morphogenesis [GO:0035128]; protein localization to cell surface [GO:0034394]; protein targeting to ER [GO:0045047]; protein targeting to lysosome [GO:0006622]; regulation of growth [GO:0040008]; respiratory electron transport chain [GO:0022904]; response to antibiotic [GO:0046677]; response to calcium ion [GO:0051592]; retrograde transport, endosome to Golgi [GO:0042147]; skeletal muscle tissue growth [GO:0048630]; spermatid differentiation [GO:0048515]; sphingolipid catabolic process [GO:0030149]; striated muscle contraction [GO:0006941]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]; thrombin-activated receptor signaling pathway [GO:0070493]; ubiquitin recycling [GO:0010992]; vacuole organization [GO:0007033]; vesicle-mediated cholesterol transport [GO:0090119]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:18367545, ECO:0000269|PubMed:25799061}. Membrane {ECO:0000250|UniProtKB:Q9JMK8}. Note=Associates with membranes in an EIPR1-independent manner. {ECO:0000250|UniProtKB:Q9JMK8}.
Q9P1T7	reviewed	MDFIC_HUMAN	MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC)	MDFIC	Homo sapiens (Human)	246	FUNCTION: Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta (PubMed:16260749, PubMed:12944466, Ref.6). Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR (PubMed:10671520). Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Has a role in the development of lymphatic vessel valves. It is required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (PubMed:35235341) (By similarity). {ECO:0000250|UniProtKB:Q8BX65, ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|PubMed:35235341, ECO:0000269|Ref.6}.	MISCELLANEOUS: [Isoform 2]: Major isoform.; MISCELLANEOUS: [Isoform 1]: Minor isoform. Initiates from a GTG codon. Contains a Nucleolar localization signal at positions 45-63. {ECO:0000305}.	negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein import into nucleus [GO:0042308]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of viral transcription [GO:0050434]; regulation of JNK cascade [GO:0046328]; regulation of Wnt signaling pathway [GO:0030111]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cyclin binding [GO:0030332]; DNA-binding transcription factor binding [GO:0140297]; Tat protein binding [GO:0030957]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cyclin binding [GO:0030332]; DNA-binding transcription factor binding [GO:0140297]; Tat protein binding [GO:0030957]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein import into nucleus [GO:0042308]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of viral transcription [GO:0050434]; regulation of JNK cascade [GO:0046328]; regulation of Wnt signaling pathway [GO:0030111]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:11139147, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|PubMed:35235341}. Cell membrane {ECO:0000250|UniProtKB:Q8BX65}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8BX65}. Secreted {ECO:0000250|UniProtKB:Q8BX65}.
Q9P1W3	reviewed	CSC1_HUMAN	Calcium permeable stress-gated cation channel 1 (Transmembrane protein 63C)	TMEM63C C14orf171 CSC1	Homo sapiens (Human)	806	FUNCTION: Acts as an osmosensitive calcium-permeable cation channel (PubMed:24503647). Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). {ECO:0000250|UniProtKB:D3ZNF5, ECO:0000269|PubMed:24503647}.		glomerular filtration [GO:0003094]; monoatomic cation transport [GO:0006812]	plasma membrane [GO:0005886]	calcium activated cation channel activity [GO:0005227]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]	plasma membrane [GO:0005886]; calcium activated cation channel activity [GO:0005227]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]; glomerular filtration [GO:0003094]; monoatomic cation transport [GO:0006812]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8CBX0}; Multi-pass membrane protein {ECO:0000255}.
Q9P1W8	reviewed	SIRPG_HUMAN	Signal-regulatory protein gamma (SIRP-gamma) (CD172 antigen-like family member B) (Signal-regulatory protein beta-2) (SIRP-b2) (SIRP-beta-2) (CD antigen CD172g)	SIRPG SIRPB2	Homo sapiens (Human)	387	FUNCTION: Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. {ECO:0000269|PubMed:15383453}.		cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; intracellular signal transduction [GO:0035556]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870]	membrane [GO:0016020]; plasma membrane [GO:0005886]		membrane [GO:0016020]; plasma membrane [GO:0005886]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; intracellular signal transduction [GO:0035556]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15383453}; Single-pass type I membrane protein {ECO:0000269|PubMed:15383453}.
Q9P1W9	reviewed	PIM2_HUMAN	Serine/threonine-protein kinase pim-2 (EC 2.7.11.1) (Pim-2h)	PIM2	Homo sapiens (Human)	311	FUNCTION: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate. {ECO:0000269|PubMed:18593906, ECO:0000269|PubMed:18675992, ECO:0000269|PubMed:20307683}.		apoptotic mitochondrial changes [GO:0008637]; G1/S transition of mitotic cell cycle [GO:0000082]; macroautophagy [GO:0016236]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of macroautophagy [GO:0016239]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of mitotic cell cycle [GO:0007346]; response to virus [GO:0009615]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic mitochondrial changes [GO:0008637]; G1/S transition of mitotic cell cycle [GO:0000082]; macroautophagy [GO:0016236]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of macroautophagy [GO:0016239]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of mitotic cell cycle [GO:0007346]; response to virus [GO:0009615]	
Q9P1Y5	reviewed	CAMP3_HUMAN	Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha)	CAMSAP3 KIAA1543	Homo sapiens (Human)	1249	FUNCTION: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.	MISCELLANEOUS: 'Nezha' is a deity in Chinese mythology. {ECO:0000305|PubMed:23169647}.	cilium movement [GO:0003341]; DNA replication checkpoint signaling [GO:0000076]; embryo development ending in birth or egg hatching [GO:0009792]; epithelial cell-cell adhesion [GO:0090136]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; in utero embryonic development [GO:0001701]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; protein transport along microtubule [GO:0098840]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of Golgi organization [GO:1903358]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle organization [GO:0033043]; replication fork arrest [GO:0043111]; zonula adherens maintenance [GO:0045218]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule minus-end [GO:0036449]; motile cilium [GO:0031514]; replication fork protection complex [GO:0031298]; zonula adherens [GO:0005915]	actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; DNA binding [GO:0003677]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule minus-end [GO:0036449]; motile cilium [GO:0031514]; replication fork protection complex [GO:0031298]; zonula adherens [GO:0005915]; actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; DNA binding [GO:0003677]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507]; cilium movement [GO:0003341]; DNA replication checkpoint signaling [GO:0000076]; embryo development ending in birth or egg hatching [GO:0009792]; epithelial cell-cell adhesion [GO:0090136]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; in utero embryonic development [GO:0001701]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; protein transport along microtubule [GO:0098840]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of Golgi organization [GO:1903358]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle organization [GO:0033043]; replication fork arrest [GO:0043111]; zonula adherens maintenance [GO:0045218]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:28386021}. Cell junction, adherens junction {ECO:0000269|PubMed:19041755}. Cytoplasm {ECO:0000269|PubMed:19041755}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q80VC9}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80VC9}. Note=Scattered in the cytoplasm, associated with the minus-end of microtubules and also detected at the centrosomes (PubMed:19041755, PubMed:24486153, PubMed:27693509). Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound (PubMed:24486153). Localizes along zonula adherens only at mature cell-cell contacts (PubMed:19041755). In early embryos, accumulates at the microtubule bridges that connect pairs of cells: this structure is present in early embryos, which lack centrosomes (By similarity). This cytokinetic bridge does not undergo stereotypical abscission after cell division (By similarity). Accumulates to the pericentrosomal region following interaction with KATNA1 (PubMed:28386021). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:28386021}.
Q9P1Z0	reviewed	ZBTB4_HUMAN	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1)	ZBTB4 KIAA1538	Homo sapiens (Human)	1013	FUNCTION: Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). {ECO:0000250|UniProtKB:Q5F293, ECO:0000269|PubMed:16354688}.		DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; methyl-CpNpG binding [GO:0010428]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]	chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; methyl-CpNpG binding [GO:0010428]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16354688}. Chromosome {ECO:0000269|PubMed:16354688}. Note=Localizes to chromocenters. {ECO:0000269|PubMed:16354688}.
Q9P1Z2	reviewed	CACO1_HUMAN	Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3)	CALCOCO1 KIAA1536 PP13275 UNQ2436/PRO4996	Homo sapiens (Human)	691	FUNCTION: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000250|UniProtKB:Q8CGU1, ECO:0000269|PubMed:24245781}.; FUNCTION: Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. {ECO:0000269|Ref.1}.		intracellular steroid hormone receptor signaling pathway [GO:0030518]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]	beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; nuclear receptor coactivator activity [GO:0030374]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; nuclear receptor coactivator activity [GO:0030374]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.
Q9P1Z3	reviewed	HCN3_HUMAN	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3	HCN3 KIAA1535	Homo sapiens (Human)	774	FUNCTION: Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions. {ECO:0000269|PubMed:16043489}.		cellular response to dopamine [GO:1903351]; potassium ion transmembrane transport [GO:0071805]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transmembrane transport [GO:0035725]	axon [GO:0030424]; cone cell pedicle [GO:0044316]; dendrite [GO:0030425]; HCN channel complex [GO:0098855]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	cAMP binding [GO:0030552]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]	axon [GO:0030424]; cone cell pedicle [GO:0044316]; dendrite [GO:0030425]; HCN channel complex [GO:0098855]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; cAMP binding [GO:0030552]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]; cellular response to dopamine [GO:1903351]; potassium ion transmembrane transport [GO:0071805]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16043489}; Multi-pass membrane protein {ECO:0000269|PubMed:16043489}.
Q9P202	reviewed	WHRN_HUMAN	Whirlin (Autosomal recessive deafness type 31 protein)	WHRN DFNB31 KIAA1526	Homo sapiens (Human)	907	FUNCTION: Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. {ECO:0000250|UniProtKB:Q80VW5}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	auditory receptor cell stereocilium organization [GO:0060088]; cerebellar Purkinje cell layer formation [GO:0021694]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; inner ear receptor cell differentiation [GO:0060113]; inner ear receptor cell stereocilium organization [GO:0060122]; paranodal junction maintenance [GO:1990227]; positive regulation of gene expression [GO:0010628]; retina homeostasis [GO:0001895]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	actin filament [GO:0005884]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; synapse [GO:0045202]; USH2 complex [GO:1990696]	identical protein binding [GO:0042802]	actin filament [GO:0005884]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; synapse [GO:0045202]; USH2 complex [GO:1990696]; identical protein binding [GO:0042802]; auditory receptor cell stereocilium organization [GO:0060088]; cerebellar Purkinje cell layer formation [GO:0021694]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; inner ear receptor cell differentiation [GO:0060113]; inner ear receptor cell stereocilium organization [GO:0060122]; paranodal junction maintenance [GO:1990227]; positive regulation of gene expression [GO:0010628]; retina homeostasis [GO:0001895]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q80VW5}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q80VW5}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q80VW5}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q80VW5}. Synapse {ECO:0000250|UniProtKB:Q810W9}. Note=Detected at the level of stereocilia in inner and outer hair cells of the cochlea and vestibule. Localizes to both tip and ankle-link stereocilia regions. Colocalizes with the growing ends of actin filaments. Colocalizes with MPP1 in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC). In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex. {ECO:0000250|UniProtKB:Q80VW5, ECO:0000250|UniProtKB:Q810W9, ECO:0000269|PubMed:17584769}.
Q9P209	reviewed	CEP72_HUMAN	Centrosomal protein of 72 kDa (Cep72)	CEP72 KIAA1519	Homo sapiens (Human)	647	FUNCTION: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:19536135, ECO:0000269|PubMed:26297806}.		centriole replication [GO:0007099]; gamma-tubulin complex localization [GO:0033566]; regulation of protein localization to centrosome [GO:1904779]; spindle organization [GO:0007051]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]		centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; centriole replication [GO:0007099]; gamma-tubulin complex localization [GO:0033566]; regulation of protein localization to centrosome [GO:1904779]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:19536135}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26297806}. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner.
Q9P212	reviewed	PLCE1_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)	PLCE1 KIAA1516 PLCE PPLC	Homo sapiens (Human)	2302	FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11395506, ECO:0000269|PubMed:11715024, ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:17086182, ECO:0000269|PubMed:29058690}.		calcium-mediated signaling [GO:0019722]; cytoskeleton organization [GO:0007010]; diacylglycerol biosynthetic process [GO:0006651]; epidermal growth factor receptor signaling pathway [GO:0007173]; glomerulus development [GO:0032835]; heart development [GO:0007507]; inositol phosphate-mediated signaling [GO:0048016]; lipid catabolic process [GO:0016042]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of cell growth [GO:0001558]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of protein kinase activity [GO:0045859]; regulation of Ras protein signal transduction [GO:0046578]; regulation of smooth muscle contraction [GO:0006940]; release of sequestered calcium ion into cytosol [GO:0051209]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; small GTPase binding [GO:0031267]; calcium-mediated signaling [GO:0019722]; cytoskeleton organization [GO:0007010]; diacylglycerol biosynthetic process [GO:0006651]; epidermal growth factor receptor signaling pathway [GO:0007173]; glomerulus development [GO:0032835]; heart development [GO:0007507]; inositol phosphate-mediated signaling [GO:0048016]; lipid catabolic process [GO:0016042]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of cell growth [GO:0001558]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of protein kinase activity [GO:0045859]; regulation of Ras protein signal transduction [GO:0046578]; regulation of smooth muscle contraction [GO:0006940]; release of sequestered calcium ion into cytosol [GO:0051209]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Cell projection, lamellipodium {ECO:0000269|PubMed:29058690}. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.
Q9P218	reviewed	COKA1_HUMAN	Collagen alpha-1(XX) chain	COL20A1 KIAA1510	Homo sapiens (Human)	1284	FUNCTION: Probable collagen protein.			collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]		collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000305}.
Q9P219	reviewed	DAPLE_HUMAN	Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2)	CCDC88C DAPLE KIAA1509	Homo sapiens (Human)	2028	FUNCTION: Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}.	MISCELLANEOUS: [Isoform 3]: Due to intron retention. {ECO:0000305}.	apical constriction [GO:0003383]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-canonical Wnt signaling pathway [GO:0035567]; protein destabilization [GO:0031648]; regulation of protein phosphorylation [GO:0001932]; small GTPase mediated signal transduction [GO:0007264]; stress-activated protein kinase signaling cascade [GO:0031098]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]	dynein light intermediate chain binding [GO:0051959]; frizzled binding [GO:0005109]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; PDZ domain binding [GO:0030165]; protein self-association [GO:0043621]	anchoring junction [GO:0070161]; cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; dynein light intermediate chain binding [GO:0051959]; frizzled binding [GO:0005109]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; PDZ domain binding [GO:0030165]; protein self-association [GO:0043621]; apical constriction [GO:0003383]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-canonical Wnt signaling pathway [GO:0035567]; protein destabilization [GO:0031648]; regulation of protein phosphorylation [GO:0001932]; small GTPase mediated signal transduction [GO:0007264]; stress-activated protein kinase signaling cascade [GO:0031098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25062847, ECO:0000269|PubMed:26126266}. Cell junction {ECO:0000269|PubMed:30948426}. Note=Enriched at apical cell junctions. {ECO:0000269|PubMed:30948426}.
Q9P225	reviewed	DYH2_HUMAN	Dynein axonemal heavy chain 2 (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2) (Dynein heavy chain domain-containing protein 3)	DNAH2 DNAHC2 DNHD3 KIAA1503	Homo sapiens (Human)	4427	FUNCTION: As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30811583). Expressed in sperm flagellum, it is required for sperm motility (PubMed:30811583). Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30811583). {ECO:0000269|PubMed:30811583}.		cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; inner dynein arm assembly [GO:0036159]	9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein complex [GO:0030286]; inner dynein arm [GO:0036156]; microtubule [GO:0005874]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein complex [GO:0030286]; inner dynein arm [GO:0036156]; microtubule [GO:0005874]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]; cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; inner dynein arm assembly [GO:0036159]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:P0C6F1}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:30811583}.
Q9P232	reviewed	CNTN3_HUMAN	Contactin-3 (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein)	CNTN3 KIAA1496 PANG	Homo sapiens (Human)	1028	FUNCTION: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Q9P241	reviewed	AT10D_HUMAN	Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D)	ATP10D ATPVD KIAA1487	Homo sapiens (Human)	1426	FUNCTION: Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane. {ECO:0000269|PubMed:30530492}.		monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:30530492}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25947375}; Multi-pass membrane protein {ECO:0000255}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B. {ECO:0000269|PubMed:25947375}.
Q9P243	reviewed	ZFAT_HUMAN	Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406)	ZFAT KIAA1485 ZFAT1 ZNF406	Homo sapiens (Human)	1243	FUNCTION: May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}.		hematopoietic progenitor cell differentiation [GO:0002244]; regulation of DNA-templated transcription [GO:0006355]; spongiotrophoblast layer development [GO:0060712]	cytosol [GO:0005829]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of DNA-templated transcription [GO:0006355]; spongiotrophoblast layer development [GO:0060712]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
Q9P246	reviewed	STIM2_HUMAN	Stromal interaction molecule 2	STIM2 KIAA1482	Homo sapiens (Human)	746	FUNCTION: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}.		activation of store-operated calcium channel activity [GO:0032237]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of calcium ion transport [GO:0051928]; store-operated calcium entry [GO:0002115]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; store-operated calcium channel activity [GO:0015279]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; store-operated calcium channel activity [GO:0015279]; activation of store-operated calcium channel activity [GO:0032237]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of calcium ion transport [GO:0051928]; store-operated calcium entry [GO:0002115]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}; Single-pass type I membrane protein {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
Q9P253	reviewed	VPS18_HUMAN	Vacuolar protein sorting-associated protein 18 homolog (hVPS18)	VPS18 KIAA1475	Homo sapiens (Human)	973	FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity). {ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25783203}.		autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; organelle fusion [GO:0048284]; protein ubiquitination [GO:0016567]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic vesicle exocytosis [GO:2000300]; vesicle docking involved in exocytosis [GO:0006904]; viral entry into host cell [GO:0046718]	actin filament [GO:0005884]; AP-3 adaptor complex [GO:0030123]; autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; presynapse [GO:0098793]	actin binding [GO:0003779]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; syntaxin binding [GO:0019905]; ubiquitin protein ligase activity [GO:0061630]	actin filament [GO:0005884]; AP-3 adaptor complex [GO:0030123]; autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; presynapse [GO:0098793]; actin binding [GO:0003779]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; syntaxin binding [GO:0019905]; ubiquitin protein ligase activity [GO:0061630]; autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; organelle fusion [GO:0048284]; protein ubiquitination [GO:0016567]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic vesicle exocytosis [GO:2000300]; vesicle docking involved in exocytosis [GO:0006904]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:11382755}; Peripheral membrane protein {ECO:0000269|PubMed:11382755}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:11382755, ECO:0000269|PubMed:21802320}; Peripheral membrane protein {ECO:0000269|PubMed:11382755}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:18552835}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000305}. Note=Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.
Q9P258	reviewed	RCC2_HUMAN	Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa)	RCC2 KIAA1470 TD60	Homo sapiens (Human)	522	FUNCTION: Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:23388455, PubMed:12919680, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:26158537, ECO:0000269|PubMed:28869598}.		cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome passenger complex localization to kinetochore [GO:0072356]; establishment of protein localization [GO:0045184]; focal adhesion assembly [GO:0048041]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GTPase activity [GO:0034260]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; regulation of cell migration [GO:0030334]; regulation of fibroblast migration [GO:0010762]; regulation of ruffle assembly [GO:1900027]	chromosome, centromeric core domain [GO:0034506]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]	chromosome, centromeric core domain [GO:0034506]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome passenger complex localization to kinetochore [GO:0072356]; establishment of protein localization [GO:0045184]; focal adhesion assembly [GO:0048041]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GTPase activity [GO:0034260]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; regulation of cell migration [GO:0030334]; regulation of fibroblast migration [GO:0010762]; regulation of ruffle assembly [GO:1900027]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:23388455}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23388455}. Chromosome, centromere {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Chromosome {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Midbody {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Cell membrane {ECO:0000269|PubMed:25074804}; Peripheral membrane protein {ECO:0000305|PubMed:25074804}; Cytoplasmic side {ECO:0000305|PubMed:25074804}. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex (PubMed:12919680, PubMed:1939370, PubMed:7559776, PubMed:9914378). Colocalizes with cytoplasmic microtubules in interphase cells (PubMed:23388455). Colocalizes with RAC1 at the cell membrane (PubMed:25074804). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:7559776, ECO:0000269|PubMed:9914378}.
Q9P266	reviewed	JCAD_HUMAN	Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD)	JCAD KIAA1462	Homo sapiens (Human)	1359			cell adhesion [GO:0007155]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]	adherens junction [GO:0005912]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587]		adherens junction [GO:0005912]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587]; cell adhesion [GO:0007155]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000250|UniProtKB:Q5DTX6}. Note=Colocalizes with CDH5/VE-Cadherin in endothelial cells but not in epithelial cells. {ECO:0000250|UniProtKB:Q5DTX6}.
Q9P267	reviewed	MBD5_HUMAN	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5)	MBD5 KIAA1461	Homo sapiens (Human)	1494	FUNCTION: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).		glucose homeostasis [GO:0042593]; nervous system development [GO:0007399]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; regulation of behavior [GO:0050795]; regulation of multicellular organism growth [GO:0040014]	chromocenter [GO:0010369]; chromosome [GO:0005694]; extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	chromocenter [GO:0010369]; chromosome [GO:0005694]; extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; glucose homeostasis [GO:0042593]; nervous system development [GO:0007399]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; regulation of behavior [GO:0050795]; regulation of multicellular organism growth [GO:0040014]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Chromosome. Note=Associated with pericentric heterochromatin.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Note=Not associated with pericentric heterochromatin.
Q9P270	reviewed	SLAI2_HUMAN	SLAIN motif-containing protein 2	SLAIN2 KIAA1458	Homo sapiens (Human)	581	FUNCTION: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.		cytoplasmic microtubule organization [GO:0031122]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116]	centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]		centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; cytoplasmic microtubule organization [GO:0031122]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules.
Q9P272	reviewed	TRM9B_HUMAN	Probable tRNA methyltransferase 9B (Probable tRNA methyltransferase 9-like protein) (EC 2.1.1.-)	TRMT9B C8orf79 KIAA1456 TRM9L	Homo sapiens (Human)	454	FUNCTION: May modify wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9. {ECO:0000269|PubMed:23381944}.		tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA wobble uridine modification [GO:0002098]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity [GO:0106335]; tRNA binding [GO:0000049]; tRNA methyltransferase activity [GO:0008175]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity [GO:0106335]; tRNA binding [GO:0000049]; tRNA methyltransferase activity [GO:0008175]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA wobble uridine modification [GO:0002098]	
Q9P273	reviewed	TEN3_HUMAN	Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3)	TENM3 KIAA1455 ODZ3 TNM3	Homo sapiens (Human)	2699	FUNCTION: Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}.		camera-type eye morphogenesis [GO:0048593]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron development [GO:0048666]; positive regulation of neuron projection development [GO:0010976]; regulation of homophilic cell adhesion [GO:1903385]; signal transduction [GO:0007165]	axon [GO:0030424]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; camera-type eye morphogenesis [GO:0048593]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron development [GO:0048666]; positive regulation of neuron projection development [GO:0010976]; regulation of homophilic cell adhesion [GO:1903385]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9WTS6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WTS6}. Cell projection, axon {ECO:0000250|UniProtKB:Q9WTS6}.
Q9P275	reviewed	UBP36_HUMAN	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36)	USP36 KIAA1453	Homo sapiens (Human)	1123	FUNCTION: Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:29273634, PubMed:19208757, PubMed:22902402). Required for cell and organism viability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368}.		chromatin organization [GO:0006325]; negative regulation of macroautophagy [GO:0016242]; nucleolus organization [GO:0007000]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of protein stability [GO:0031647]; regulation of rRNA processing [GO:2000232]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; RNA binding [GO:0003723]; chromatin organization [GO:0006325]; negative regulation of macroautophagy [GO:0016242]; nucleolus organization [GO:0007000]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of protein stability [GO:0031647]; regulation of rRNA processing [GO:2000232]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338}. Cytoplasm {ECO:0000269|PubMed:27445338}.
Q9P278	reviewed	FNIP2_HUMAN	Folliculin-interacting protein 2 (FNIP1-like protein) (O6-methylguanine-induced apoptosis 1 protein)	FNIP2 FNIPL KIAA1450 MAPO1	Homo sapiens (Human)	1114	FUNCTION: Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:18663353, PubMed:31672913, PubMed:36103527). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (By similarity). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (PubMed:31672913, PubMed:36103527). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:31672913). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:18403135). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:18403135). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:18403135). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). {ECO:0000250|UniProtKB:Q80TD3, ECO:0000250|UniProtKB:Q8TF40, ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36103527}.		intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of TORC1 signaling [GO:1904263]; protein phosphorylation [GO:0006468]; regulation of protein phosphorylation [GO:0001932]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; lysosomal membrane [GO:0005765]	ATPase inhibitor activity [GO:0042030]; protein-folding chaperone binding [GO:0051087]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; lysosomal membrane [GO:0005765]; ATPase inhibitor activity [GO:0042030]; protein-folding chaperone binding [GO:0051087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of TORC1 signaling [GO:1904263]; protein phosphorylation [GO:0006468]; regulation of protein phosphorylation [GO:0001932]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000305|PubMed:31672913}. Cytoplasm {ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:19137017}. Note=Colocalizes with FLCN in the cytoplasm. {ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353}.
Q9P283	reviewed	SEM5B_HUMAN	Semaphorin-5B	SEMA5B KIAA1445 SEMAG UNQ5867/PRO34001	Homo sapiens (Human)	1151	FUNCTION: May act as a positive axonal guidance cue. {ECO:0000250|UniProtKB:Q60519}.		axon extension [GO:0048675]; axon guidance [GO:0007411]; detection of light stimulus involved in visual perception [GO:0050908]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	membrane [GO:0016020]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	membrane [GO:0016020]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; axon extension [GO:0048675]; axon guidance [GO:0007411]; detection of light stimulus involved in visual perception [GO:0050908]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type III membrane protein {ECO:0000255}.
Q9P286	reviewed	PAK5_HUMAN	Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7)	PAK5 KIAA1264 PAK7	Homo sapiens (Human)	719	FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. {ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16014608, ECO:0000269|PubMed:16581795, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:20564219}.		apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; locomotory behavior [GO:0007626]; memory [GO:0007613]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; phosphorylation [GO:0016310]; regulation of cell growth [GO:0001558]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; locomotory behavior [GO:0007626]; memory [GO:0007613]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; phosphorylation [GO:0016310]; regulation of cell growth [GO:0001558]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
Q9P287	reviewed	BCCIP_HUMAN	BRCA2 and CDKN1A-interacting protein (P21- and CDK-associated protein 1) (Protein TOK-1)	BCCIP TOK1	Homo sapiens (Human)	314	FUNCTION: During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:14726710, ECO:0000269|PubMed:15539944, ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:17947333, ECO:0000269|PubMed:28394342}.	MISCELLANEOUS: HT1080 cells that constitutively express low levels of BCCIP display increased levels of spontaneous single-stranded DNA and double-strand breaks.	DNA repair [GO:0006281]; establishment of mitotic spindle orientation [GO:0000132]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; neuroendocrine cell differentiation [GO:0061101]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; mitotic spindle pole [GO:0097431]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	kinase regulator activity [GO:0019207]; RNA binding [GO:0003723]; tubulin binding [GO:0015631]	centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; mitotic spindle pole [GO:0097431]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; kinase regulator activity [GO:0019207]; RNA binding [GO:0003723]; tubulin binding [GO:0015631]; DNA repair [GO:0006281]; establishment of mitotic spindle orientation [GO:0000132]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; neuroendocrine cell differentiation [GO:0061101]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:11313963, ECO:0000269|PubMed:15713648}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Colocalizes with BRCA2 in discrete nuclear foci (PubMed:15713648). In interphase, preferential localizes to the mother centriole (PubMed:28394342). Recruited to the spindle pole matrix and centrosome by microtubules and dynein/dynactin activity (PubMed:28394342). {ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:28394342}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Isoform 1/beta tends to be less abundant at, and less strongly associated with, centrosomes than isoform 2/alpha. {ECO:0000269|PubMed:28394342}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Isoform 2/alpha tends to be more abundant at, and more strongly associated with, centrosomes than isoform 1/beta. {ECO:0000269|PubMed:28394342}.
Q9P289	reviewed	STK26_HUMAN	Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK)	STK26 MASK MST4	Homo sapiens (Human)	416	FUNCTION: Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:27807006, ECO:0000269|PubMed:29232556}.		apoptotic process [GO:0006915]; cellular response to starvation [GO:0009267]; microvillus assembly [GO:0030033]; negative regulation of cell migration [GO:0030336]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; response to hydrogen peroxide [GO:0042542]; stress-activated protein kinase signaling cascade [GO:0031098]	apical plasma membrane [GO:0016324]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vesicle membrane [GO:0012506]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	apical plasma membrane [GO:0016324]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vesicle membrane [GO:0012506]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cellular response to starvation [GO:0009267]; microvillus assembly [GO:0030033]; negative regulation of cell migration [GO:0030336]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; response to hydrogen peroxide [GO:0042542]; stress-activated protein kinase signaling cascade [GO:0031098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:27807006}. Golgi apparatus {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:27807006}. Note=Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006). {ECO:0000269|PubMed:27807006}.
Q9P296	reviewed	C5AR2_HUMAN	C5a anaphylatoxin chemotactic receptor 2 (Complement component 5a receptor 2) (G-protein coupled receptor 77)	C5AR2 C5L2 GPR77	Homo sapiens (Human)	337	FUNCTION: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. {ECO:0000269|PubMed:11773063, ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:19615750}.		chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; inflammatory response [GO:0006954]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of tumor necrosis factor production [GO:0032720]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of interleukin-8 production [GO:0032677]	apical part of cell [GO:0045177]; basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]	complement component C5a receptor activity [GO:0004878]; G protein-coupled receptor activity [GO:0004930]	apical part of cell [GO:0045177]; basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; complement component C5a receptor activity [GO:0004878]; G protein-coupled receptor activity [GO:0004930]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; inflammatory response [GO:0006954]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of tumor necrosis factor production [GO:0032720]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of interleukin-8 production [GO:0032677]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19615750}; Multi-pass membrane protein {ECO:0000269|PubMed:19615750}.
Q9P2A4	reviewed	ABI3_HUMAN	ABI gene family member 3 (New molecule including SH3) (Nesh)	ABI3 NESH	Homo sapiens (Human)	366	FUNCTION: May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility. {ECO:0000250, ECO:0000269|PubMed:11956071}.		actin cytoskeleton organization [GO:0030036]; defense response to tumor cell [GO:0002357]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of ruffle assembly [GO:1900028]; positive regulation of cellular senescence [GO:2000774]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of postsynaptic density assembly [GO:0099151]	cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; lamellipodium [GO:0030027]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; SCAR complex [GO:0031209]	actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; lamellipodium [GO:0030027]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; SCAR complex [GO:0031209]; actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; actin cytoskeleton organization [GO:0030036]; defense response to tumor cell [GO:0002357]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of ruffle assembly [GO:1900028]; positive regulation of cellular senescence [GO:2000774]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of postsynaptic density assembly [GO:0099151]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11956071}. Note=Colocalizes with PAK2 at leading edge of cells.
Q9P2B2	reviewed	FPRP_HUMAN	Prostaglandin F2 receptor negative regulator (CD9 partner 1) (CD9P-1) (Glu-Trp-Ile EWI motif-containing protein F) (EWI-F) (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD antigen CD315)	PTGFRN CD9P1 EWIF FPRP KIAA1436	Homo sapiens (Human)	879	FUNCTION: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9WV91}.		lipid droplet organization [GO:0034389]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]	cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]		cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lipid droplet organization [GO:0034389]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9P2B4	reviewed	CT2NL_HUMAN	CTTNBP2 N-terminal-like protein	CTTNBP2NL KIAA1433	Homo sapiens (Human)	639	FUNCTION: Regulates lamellipodial actin dynamics in a CTTN-dependent manner. {ECO:0000250|UniProtKB:Q8SX68}.		negative regulation of transmembrane transport [GO:0034763]; negative regulation of transporter activity [GO:0032410]; protein dephosphorylation [GO:0006470]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]	protein phosphatase 2A binding [GO:0051721]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; protein phosphatase 2A binding [GO:0051721]; negative regulation of transmembrane transport [GO:0034763]; negative regulation of transporter activity [GO:0032410]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q8SX68}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q99LJ0}.
Q9P2D0	reviewed	IBTK_HUMAN	Inhibitor of Bruton tyrosine kinase (IBtk)	IBTK BTKI KIAA1417	Homo sapiens (Human)	1353	FUNCTION: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}.	MISCELLANEOUS: [Isoform 2]: Due to a partial intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Due to a partial intron retention. {ECO:0000305}.	negative regulation of protein phosphorylation [GO:0001933]; release of sequestered calcium ion into cytosol [GO:0051209]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	protein kinase binding [GO:0019901]; protein tyrosine kinase inhibitor activity [GO:0030292]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; protein kinase binding [GO:0019901]; protein tyrosine kinase inhibitor activity [GO:0030292]; negative regulation of protein phosphorylation [GO:0001933]; release of sequestered calcium ion into cytosol [GO:0051209]	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
Q9P2D1	reviewed	CHD7_HUMAN	Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.12) (ATP-dependent helicase CHD7)	CHD7 KIAA1416	Homo sapiens (Human)	2997	FUNCTION: Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Ubiquitous, expression enriched in lung and large intestine. {ECO:0000305}.	adult heart development [GO:0007512]; adult walking behavior [GO:0007628]; aorta morphogenesis [GO:0035909]; atrioventricular canal development [GO:0036302]; blood circulation [GO:0008015]; blood vessel remodeling [GO:0001974]; cardiac septum morphogenesis [GO:0060411]; central nervous system development [GO:0007417]; chordate embryonic development [GO:0043009]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; cranial nerve development [GO:0021545]; embryonic hindlimb morphogenesis [GO:0035116]; epithelium development [GO:0060429]; face development [GO:0060324]; female genitalia development [GO:0030540]; genitalia development [GO:0048806]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; innervation [GO:0060384]; limb development [GO:0060173]; nose development [GO:0043584]; olfactory behavior [GO:0042048]; olfactory bulb development [GO:0021772]; olfactory nerve development [GO:0021553]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of growth hormone secretion [GO:0060123]; regulation of neurogenesis [GO:0050767]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to bacterium [GO:0009617]; retina development in camera-type eye [GO:0060041]; right ventricular compact myocardium morphogenesis [GO:0003226]; rRNA processing [GO:0006364]; secondary palate development [GO:0062009]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]; ventricular trabecula myocardium morphogenesis [GO:0003222]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; adult heart development [GO:0007512]; adult walking behavior [GO:0007628]; aorta morphogenesis [GO:0035909]; atrioventricular canal development [GO:0036302]; blood circulation [GO:0008015]; blood vessel remodeling [GO:0001974]; cardiac septum morphogenesis [GO:0060411]; central nervous system development [GO:0007417]; chordate embryonic development [GO:0043009]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; cranial nerve development [GO:0021545]; embryonic hindlimb morphogenesis [GO:0035116]; epithelium development [GO:0060429]; face development [GO:0060324]; female genitalia development [GO:0030540]; genitalia development [GO:0048806]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; innervation [GO:0060384]; limb development [GO:0060173]; nose development [GO:0043584]; olfactory behavior [GO:0042048]; olfactory bulb development [GO:0021772]; olfactory nerve development [GO:0021553]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of growth hormone secretion [GO:0060123]; regulation of neurogenesis [GO:0050767]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to bacterium [GO:0009617]; retina development in camera-type eye [GO:0060041]; right ventricular compact myocardium morphogenesis [GO:0003226]; rRNA processing [GO:0006364]; secondary palate development [GO:0062009]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]; ventricular trabecula myocardium morphogenesis [GO:0003222]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:20453063}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleolus {ECO:0000269|PubMed:22646239}.
Q9P2D3	reviewed	HTR5B_HUMAN	HEAT repeat-containing protein 5B	HEATR5B KIAA1414 p200 p200a	Homo sapiens (Human)	2071	FUNCTION: Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}.		endocytosis [GO:0006897]; protein localization [GO:0008104]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471]		clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471]; endocytosis [GO:0006897]; protein localization [GO:0008104]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15758025}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:15758025}. Note=Localization at clathrin-coated vesicles depends on AFTPH/aftiphilin. {ECO:0000269|PubMed:15758025}.
Q9P2D7	reviewed	DYH1_HUMAN	Dynein axonemal heavy chain 1 (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1) (Heat shock regulated protein 1) (HSRF-1) (hDHC7)	DNAH1 DHC7 DNAHC1 KIAA1410	Homo sapiens (Human)	4265	FUNCTION: Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805). {ECO:0000250|UniProtKB:Q91XQ0, ECO:0000269|PubMed:24360805}.		cilium-dependent cell motility [GO:0060285]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; sperm axoneme assembly [GO:0007288]	axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; extracellular region [GO:0005576]; inner dynein arm [GO:0036156]; microtubule [GO:0005874]; sperm flagellum [GO:0036126]	ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]	axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; extracellular region [GO:0005576]; inner dynein arm [GO:0036156]; microtubule [GO:0005874]; sperm flagellum [GO:0036126]; ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]; cilium-dependent cell motility [GO:0060285]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:24360805}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:E9Q8T7}.
Q9P2E2	reviewed	KIF17_HUMAN	Kinesin-like protein KIF17 (KIF3-related motor protein)	KIF17 KIAA1405 KIF3X	Homo sapiens (Human)	1029	FUNCTION: Dendrite-specific motor protein which, in association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. {ECO:0000250|UniProtKB:Q99PW8}.		anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; cell projection organization [GO:0030030]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; neuron projection [GO:0043005]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; neuron projection [GO:0043005]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; cell projection organization [GO:0030030]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:Q99PW8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99PW8}. Note=Localizes to dendrites of pyramidal neurons (By similarity). Does not localize to the axons or nuclei in cerebral cortex, hippocampus or olfactory bulb (By similarity). Co-localizes with NR2B-containing vesicles along microtubules (By similarity). {ECO:0000250|UniProtKB:Q99PW8}.
Q9P2E3	reviewed	ZNFX1_HUMAN	NFX1-type zinc finger-containing protein 1	ZNFX1 KIAA1404	Homo sapiens (Human)	1918	FUNCTION: RNA-binding protein that initiates the antiviral response and is required to restrict the replication of RNA viruses (PubMed:33872655). Acts as a double-stranded RNA (dsRNA) sensor that recognizes viral RNA and then interacts with MAVS to initiate the type I interferon response (By similarity). Also required for immunity against some bacteria, such as mycobacteria (PubMed:33876776). {ECO:0000250|UniProtKB:Q8R151, ECO:0000269|PubMed:33872655, ECO:0000269|PubMed:33876776}.		activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	cytoplasmic stress granule [GO:0010494]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380]	helicase activity [GO:0004386]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasmic stress granule [GO:0010494]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8R151}. Cytoplasm, Stress granule {ECO:0000269|PubMed:33876776}.
Q9P2E5	reviewed	CHPF2_HUMAN	Chondroitin sulfate glucuronyltransferase (EC 2.4.1.226) (CSGlcA-T) (Chondroitin glucuronyltransferase) (Chondroitin polymerizing factor 2) (ChPF-2) (Chondroitin synthase 3) (ChSy-3) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase)	CHPF2 CHSY3 CSGLCAT KIAA1402 UNQ299/PRO339	Homo sapiens (Human)	772	FUNCTION: Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity. {ECO:0000269|PubMed:12145278, ECO:0000269|PubMed:18316376}.		chondroitin sulfate biosynthetic process [GO:0030206]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510]; chondroitin sulfate biosynthetic process [GO:0030206]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9P2E8	reviewed	MARH4_HUMAN	E3 ubiquitin-protein ligase MARCHF4 (EC 2.3.2.27) (Membrane-associated RING finger protein 4) (Membrane-associated RING-CH protein IV) (MARCH-IV) (RING finger protein 174) (RING-type E3 ubiquitin transferase MARCHF4)	MARCHF4 KIAA1399 MARCH4 RNF174	Homo sapiens (Human)	410	FUNCTION: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269|PubMed:14722266}.		protein ubiquitination [GO:0016567]	Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; trans-Golgi network [GO:0005802]	ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; trans-Golgi network [GO:0005802]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000269|PubMed:14722266}.
Q9P2E9	reviewed	RRBP1_HUMAN	Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein)	RRBP1 KIAA1398	Homo sapiens (Human)	1410	FUNCTION: Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.		osteoblast differentiation [GO:0001649]; protein transport [GO:0015031]; translation [GO:0006412]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; ribosome [GO:0005840]	RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; ribosome [GO:0005840]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; osteoblast differentiation [GO:0001649]; protein transport [GO:0015031]; translation [GO:0006412]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Q9P2F6	reviewed	RHG20_HUMAN	Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20)	ARHGAP20 KIAA1391	Homo sapiens (Human)	1191	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.		regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	
Q9P2F9	reviewed	ZN319_HUMAN	Zinc finger protein 319	ZNF319 KIAA1388	Homo sapiens (Human)	582	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9P2G1	reviewed	AKIB1_HUMAN	Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31)	ANKIB1 KIAA1386	Homo sapiens (Human)	1089	FUNCTION: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}.		positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q9P2G3	reviewed	KLH14_HUMAN	Kelch-like protein 14 (Protein interactor of Torsin-1A) (Printor) (Protein interactor of torsinA)	KLHL14 KIAA1384	Homo sapiens (Human)	628				actin cytoskeleton [GO:0015629]; aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]		actin cytoskeleton [GO:0015629]; aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19535332}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19535332}. Note=Colocalizes with TOR1A at the endoplasmic reticulum level.
Q9P2G4	reviewed	MAP10_HUMAN	Microtubule-associated protein 10 (Microtubule regulator of 120 KDa)	MAP10 KIAA1383 MTR120	Homo sapiens (Human)	905	FUNCTION: Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis. {ECO:0000269|PubMed:23264731}.		cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cytokinesis [GO:0032467]; regulation of microtubule-based process [GO:0032886]	centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]	microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; microtubule binding [GO:0008017]; cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cytokinesis [GO:0032467]; regulation of microtubule-based process [GO:0032886]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23264731}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23264731}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23264731}. Midbody {ECO:0000269|PubMed:23264731}. Note=Localized at stabilized microtubules (MTs) during interphase and to the mitotic apparatus during mitosis. Localized at spindle poles in metaphase and spindle midzone during telophase. Colocalized with Polo-like kinase PLK1 to the center of spindle midzone. Localized at the midbody during cytokinesis. Colocalized with acetylated-tubulin at MTs.
Q9P2G9	reviewed	KLHL8_HUMAN	Kelch-like protein 8	KLHL8 KIAA1378	Homo sapiens (Human)	620	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN. {ECO:0000269|PubMed:19158078}.		protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	Cul3-RING ubiquitin ligase complex [GO:0031463]; nucleoplasm [GO:0005654]		Cul3-RING ubiquitin ligase complex [GO:0031463]; nucleoplasm [GO:0005654]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q9P2H0	reviewed	CE126_HUMAN	Centrosomal protein of 126 kDa	CEP126 KIAA1377	Homo sapiens (Human)	1117	FUNCTION: Participates in cytokinesis (PubMed:19799413). Necessary for microtubules and mitotic spindle organization (PubMed:24867236). Involved in primary cilium formation (PubMed:24867236). {ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:24867236}.	MISCELLANEOUS: Depletion of CEP126 by siRNA results in an increase in cytokinesis aberrant cells. {ECO:0000305|PubMed:19799413}.	cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; mitotic spindle organization [GO:0007052]; non-motile cilium assembly [GO:1905515]	centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; midbody [GO:0030496]		centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; midbody [GO:0030496]; cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; mitotic spindle organization [GO:0007052]; non-motile cilium assembly [GO:1905515]	SUBCELLULAR LOCATION: Midbody {ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:24867236}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24867236}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24867236}.
Q9P2H3	reviewed	IFT80_HUMAN	Intraflagellar transport protein 80 homolog (WD repeat-containing protein 56)	IFT80 KIAA1374 WDR56	Homo sapiens (Human)	777	FUNCTION: Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. {ECO:0000269|PubMed:17468754}.	MISCELLANEOUS: [Isoform IFT80-L]: Based on a naturally occurring readthrough transcript which produces a TRIM59-IFT80 fusion protein. {ECO:0000305}.	articular cartilage development [GO:0061975]; bone mineralization involved in bone maturation [GO:0035630]; cilium assembly [GO:0060271]; endochondral ossification [GO:0001958]; growth plate cartilage chondrocyte differentiation [GO:0003418]; intraciliary anterograde transport [GO:0035720]; keratinocyte proliferation [GO:0043616]; limb development [GO:0060173]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; non-canonical Wnt signaling pathway [GO:0035567]; non-motile cilium assembly [GO:1905515]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; receptor localization to non-motile cilium [GO:0097500]; smoothened signaling pathway [GO:0007224]	9+0 non-motile cilium [GO:0097731]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]		9+0 non-motile cilium [GO:0097731]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; articular cartilage development [GO:0061975]; bone mineralization involved in bone maturation [GO:0035630]; cilium assembly [GO:0060271]; endochondral ossification [GO:0001958]; growth plate cartilage chondrocyte differentiation [GO:0003418]; intraciliary anterograde transport [GO:0035720]; keratinocyte proliferation [GO:0043616]; limb development [GO:0060173]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; non-canonical Wnt signaling pathway [GO:0035567]; non-motile cilium assembly [GO:1905515]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; receptor localization to non-motile cilium [GO:0097500]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Note=Basal body and ciliary axoneme. {ECO:0000250}.
Q9P2H5	reviewed	UBP35_HUMAN	Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35)	USP35 KIAA1372 USP34	Homo sapiens (Human)	1018	FUNCTION: Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress (PubMed:26348204, PubMed:29449677, PubMed:37004621). Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination (PubMed:26348204). Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein (PubMed:29449677). In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability (PubMed:34438346). Regulates the degradation of mitochondria through the process of autophagy termed mitophagy (PubMed:25915564). {ECO:0000269|PubMed:25915564, ECO:0000269|PubMed:26348204, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:34438346, ECO:0000269|PubMed:37004621}.		protein deubiquitination [GO:0016579]	cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; protein deubiquitination [GO:0016579]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25915564}. Mitochondrion {ECO:0000269|PubMed:25915564}. Note=Only associates with polarized mitochondria, and rapidly translocates to the cytosol during mitophagy. {ECO:0000269|PubMed:25915564}.
Q9P2I0	reviewed	CPSF2_HUMAN	Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit)	CPSF2 CPSF100 KIAA1367	Homo sapiens (Human)	782	FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:18688255}.		mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; mRNA polyadenylation [GO:0006378]	glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]	RNA binding [GO:0003723]	glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; RNA binding [GO:0003723]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; mRNA polyadenylation [GO:0006378]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9P2J2	reviewed	TUTLA_HUMAN	Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A)	IGSF9 IGSF9A KIAA1355 NRT1	Homo sapiens (Human)	1179	FUNCTION: Functions in dendrite outgrowth and synapse maturation. {ECO:0000250}.		axon guidance [GO:0007411]; dendrite development [GO:0016358]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of synapse organization [GO:0050807]	axon [GO:0030424]; dendrite [GO:0030425]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]	cell-cell adhesion mediator activity [GO:0098632]	axon [GO:0030424]; dendrite [GO:0030425]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]; cell-cell adhesion mediator activity [GO:0098632]; axon guidance [GO:0007411]; dendrite development [GO:0016358]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of synapse organization [GO:0050807]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Note=Enriched at the excitatory synapses in mature neurons. {ECO:0000250}.
Q9P2J3	reviewed	KLHL9_HUMAN	Kelch-like protein 9	KLHL9 KIAA1354	Homo sapiens (Human)	617	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:17543862, ECO:0000269|PubMed:19995937}.		cell cycle [GO:0007049]; cell division [GO:0051301]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; midbody [GO:0030496]	cullin family protein binding [GO:0097602]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; midbody [GO:0030496]; cullin family protein binding [GO:0097602]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465]	
Q9P2J5	reviewed	SYLC_HUMAN	Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)	LARS1 KIAA1352 LARS	Homo sapiens (Human)	1176	FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. {ECO:0000269|PubMed:19426743}.		cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; glutaminyl-tRNA aminoacylation [GO:0006425]; leucyl-tRNA aminoacylation [GO:0006429]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of cell size [GO:0008361]; tRNA aminoacylation for protein translation [GO:0006418]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; lysosome [GO:0005764]; nuclear body [GO:0016604]	aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; GTPase activator activity [GO:0005096]; leucine-tRNA ligase activity [GO:0004823]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; lysosome [GO:0005764]; nuclear body [GO:0016604]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; GTPase activator activity [GO:0005096]; leucine-tRNA ligase activity [GO:0004823]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; glutaminyl-tRNA aminoacylation [GO:0006425]; leucyl-tRNA aminoacylation [GO:0006429]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of cell size [GO:0008361]; tRNA aminoacylation for protein translation [GO:0006418]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9P2K1	reviewed	C2D2A_HUMAN	Coiled-coil and C2 domain-containing protein 2A	CC2D2A KIAA1345	Homo sapiens (Human)	1620	FUNCTION: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250, ECO:0000269|PubMed:18513680}.		axoneme assembly [GO:0035082]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; heart development [GO:0007507]; kidney development [GO:0001822]; motile cilium assembly [GO:0044458]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]; smoothened signaling pathway [GO:0007224]	ciliary transition zone [GO:0035869]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; MKS complex [GO:0036038]		ciliary transition zone [GO:0035869]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; MKS complex [GO:0036038]; axoneme assembly [GO:0035082]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; heart development [GO:0007507]; kidney development [GO:0001822]; motile cilium assembly [GO:0044458]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250}.
Q9P2K2	reviewed	TXD16_HUMAN	Thioredoxin domain-containing protein 16	TXNDC16 ERP90 KIAA1344	Homo sapiens (Human)	825				endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]		endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25122923}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:21359175, ECO:0000269|PubMed:25122923}.
Q9P2K3	reviewed	RCOR3_HUMAN	REST corepressor 3	RCOR3 KIAA1343	Homo sapiens (Human)	495	FUNCTION: May act as a component of a corepressor complex that represses transcription. {ECO:0000305}.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	transcription corepressor activity [GO:0003714]	cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; transcription corepressor activity [GO:0003714]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.
Q9P2K5	reviewed	MYEF2_HUMAN	Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156)	MYEF2 KIAA1341	Homo sapiens (Human)	600	FUNCTION: Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). {ECO:0000250}.		myotube differentiation [GO:0014902]; neuron differentiation [GO:0030182]	nucleus [GO:0005634]	DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nucleus [GO:0005634]; DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; myotube differentiation [GO:0014902]; neuron differentiation [GO:0030182]	SUBCELLULAR LOCATION: Nucleus.
Q9P2K6	reviewed	KLH42_HUMAN	Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5)	KLHL42 KIAA1340 KLHDC5	Homo sapiens (Human)	505	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis. {ECO:0000269|PubMed:19261606}.		cell cycle [GO:0007049]; cell division [GO:0051301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of microtubule-based process [GO:0032886]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; spindle [GO:0005819]		Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; spindle [GO:0005819]; cell cycle [GO:0007049]; cell division [GO:0051301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of microtubule-based process [GO:0032886]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19261606}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19261606}. Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles. During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis.
Q9P2K8	reviewed	E2AK4_HUMAN	eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein)	EIF2AK4 GCN2 KIAA1338	Homo sapiens (Human)	1649	FUNCTION: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). {ECO:0000250|UniProtKB:P15442, ECO:0000250|UniProtKB:Q9QZ05, ECO:0000269|PubMed:25329545, ECO:0000269|PubMed:26102367, ECO:0000269|PubMed:32610081}.; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610). {ECO:0000269|PubMed:24310610}.		adaptive immune response [GO:0002250]; cell cycle [GO:0007049]; cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to leucine starvation [GO:1990253]; cellular response to UV [GO:0034644]; defense response to virus [GO:0051607]; DNA damage checkpoint signaling [GO:0000077]; eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492]; GCN2-mediated signaling [GO:0140469]; learning [GO:0007612]; long-term memory [GO:0007616]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of cytoplasmic translational initiation in response to stress [GO:1990625]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translational initiation [GO:0045947]; negative regulation of translational initiation in response to stress [GO:0032057]; neuron projection extension [GO:1990138]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of translational initiation in response to starvation [GO:0071264]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of feeding behavior [GO:0060259]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; T cell activation involved in immune response [GO:0002286]; viral translation [GO:0019081]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]; polysome [GO:0005844]	ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]; polysome [GO:0005844]; ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tRNA binding [GO:0000049]; adaptive immune response [GO:0002250]; cell cycle [GO:0007049]; cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to leucine starvation [GO:1990253]; cellular response to UV [GO:0034644]; defense response to virus [GO:0051607]; DNA damage checkpoint signaling [GO:0000077]; eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492]; GCN2-mediated signaling [GO:0140469]; learning [GO:0007612]; long-term memory [GO:0007616]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of cytoplasmic translational initiation in response to stress [GO:1990625]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translational initiation [GO:0045947]; negative regulation of translational initiation in response to stress [GO:0032057]; neuron projection extension [GO:1990138]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of translational initiation in response to starvation [GO:0071264]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of feeding behavior [GO:0060259]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; T cell activation involved in immune response [GO:0002286]; viral translation [GO:0019081]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QZ05}.
Q9P2K9	reviewed	DISP3_HUMAN	Protein dispatched homolog 3 (Patched domain-containing protein 2)	DISP3 KIAA1337 PTCHD2	Homo sapiens (Human)	1392	FUNCTION: Plays a role in neuronal proliferation and differentiation (PubMed:25281927). Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation (PubMed:25281927). May contribute to cholesterol homeostasis in neuronal cells (By similarity). {ECO:0000250|UniProtKB:B9U3F2, ECO:0000269|PubMed:25281927}.		cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of lipid metabolic process [GO:0045834]; positive regulation of neural precursor cell proliferation [GO:2000179]; regulation of lipid transport [GO:0032368]; smoothened signaling pathway [GO:0007224]	cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]		cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of lipid metabolic process [GO:0045834]; positive regulation of neural precursor cell proliferation [GO:2000179]; regulation of lipid transport [GO:0032368]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19179482}; Multi-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000269|PubMed:19179482}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:B9U3F2}; Multi-pass membrane protein {ECO:0000305}. Note=Predominantly localized to cholesterol-enriched domains within the membrane (PubMed:19179482). Localizes to cytoplasmic punctate vesicular structures (By similarity). {ECO:0000250|UniProtKB:B9U3F2, ECO:0000269|PubMed:19179482}.
Q9P2L0	reviewed	WDR35_HUMAN	WD repeat-containing protein 35 (Intraflagellar transport protein 121 homolog)	WDR35 IFT121 KIAA1336	Homo sapiens (Human)	1181	FUNCTION: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (PubMed:21473986, PubMed:28400947, PubMed:29220510). May promote CASP3 activation and TNF-stimulated apoptosis. {ECO:0000269|PubMed:20193664, ECO:0000269|PubMed:21473986, ECO:0000269|PubMed:28400947, ECO:0000269|PubMed:29220510}.		cellular response to leukemia inhibitory factor [GO:1990830]; cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; protein localization to cilium [GO:0061512]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]		axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]; cellular response to leukemia inhibitory factor [GO:1990830]; cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; protein localization to cilium [GO:0061512]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8BND3}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q8BND3}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8BND3}.
Q9P2M1	reviewed	LR2BP_HUMAN	LRP2-binding protein (Megalin-binding protein) (MegBP)	LRP2BP KIAA1325	Homo sapiens (Human)	347	FUNCTION: May act as an adapter that regulates LRP2 function.			cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12508107}. Note=Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm.
Q9P2M4	reviewed	TBC14_HUMAN	TBC1 domain family member 14	TBC1D14 KIAA1322	Homo sapiens (Human)	693	FUNCTION: Plays a role in the regulation of starvation-induced autophagosome formation (PubMed:22613832). Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. {ECO:0000269|PubMed:22613832, ECO:0000269|PubMed:26711178}.		autophagy [GO:0006914]; negative regulation of autophagy [GO:0010507]; recycling endosome to Golgi transport [GO:0071955]; regulation of autophagosome assembly [GO:2000785]	autophagosome [GO:0005776]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; recycling endosome [GO:0055037]	GTPase activator activity [GO:0005096]; protein kinase binding [GO:0019901]	autophagosome [GO:0005776]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; recycling endosome [GO:0055037]; GTPase activator activity [GO:0005096]; protein kinase binding [GO:0019901]; autophagy [GO:0006914]; negative regulation of autophagy [GO:0010507]; recycling endosome to Golgi transport [GO:0071955]; regulation of autophagosome assembly [GO:2000785]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:22613832, ECO:0000269|PubMed:26711178}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:22613832}. Note=After amino acid starvation, Golgi apparatus-associated protein levels increase compared with fed conditions. May be cycling between the Golgi apparatus and an endosomal pool, redistributing to the Golgi apparatus upon starvation.
Q9P2M7	reviewed	CING_HUMAN	Cingulin	CGN KIAA1319	Homo sapiens (Human)	1203	FUNCTION: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	microtubule cytoskeleton organization [GO:0000226]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; cadherin binding [GO:0045296]; microtubule binding [GO:0008017]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; microtubule binding [GO:0008017]; microtubule cytoskeleton organization [GO:0000226]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:P59242}. Note=Localizes to the apical junction complex composed of tight and adherens junctions (By similarity). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (PubMed:12023291). {ECO:0000250|UniProtKB:P59242, ECO:0000269|PubMed:12023291}.
Q9P2N2	reviewed	RHG28_HUMAN	Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28)	ARHGAP28 KIAA1314	Homo sapiens (Human)	729	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.		negative regulation of stress fiber assembly [GO:0051497]; regulation of actin filament polymerization [GO:0030833]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GTPase activator activity [GO:0005096]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; GTPase activator activity [GO:0005096]; negative regulation of stress fiber assembly [GO:0051497]; regulation of actin filament polymerization [GO:0030833]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	
Q9P2N4	reviewed	ATS9_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-)	ADAMTS9 KIAA1312	Homo sapiens (Human)	1935	FUNCTION: Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. {ECO:0000269|PubMed:12514189, ECO:0000269|PubMed:22419820}.	MISCELLANEOUS: [Isoform 2]: May result from the retention of an intron in the cDNA leading to a prematurate stop codon. {ECO:0000305}.	aorta morphogenesis [GO:0035909]; endothelial cell-matrix adhesion [GO:0090673]; extracellular matrix organization [GO:0030198]; heart valve morphogenesis [GO:0003179]; melanocyte differentiation [GO:0030318]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of sprouting angiogenesis [GO:1903671]; positive regulation of melanocyte differentiation [GO:0045636]; protein transport [GO:0015031]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]; ventricular cardiac muscle tissue development [GO:0003229]; vesicle-mediated transport [GO:0016192]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; aorta morphogenesis [GO:0035909]; endothelial cell-matrix adhesion [GO:0090673]; extracellular matrix organization [GO:0030198]; heart valve morphogenesis [GO:0003179]; melanocyte differentiation [GO:0030318]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of sprouting angiogenesis [GO:1903671]; positive regulation of melanocyte differentiation [GO:0045636]; protein transport [GO:0015031]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]; ventricular cardiac muscle tissue development [GO:0003229]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12514189}. Endoplasmic reticulum {ECO:0000269|PubMed:22419820}.
Q9P2N6	reviewed	KANL3_HUMAN	KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD)	KANSL3 KIAA1310 NSL3 PRTD SI1	Homo sapiens (Human)	904	FUNCTION: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269|PubMed:20018852}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	histone acetyltransferase complex [GO:0000123]; intracellular membrane-bounded organelle [GO:0043231]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]		histone acetyltransferase complex [GO:0000123]; intracellular membrane-bounded organelle [GO:0043231]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20018852}.
Q9P2N7	reviewed	KLH13_HUMAN	Kelch-like protein 13 (BTB and kelch domain-containing protein 2)	KLHL13 BKLHD2 KIAA1309	Homo sapiens (Human)	655	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:17543862, ECO:0000269|PubMed:19995937}.		cell cycle [GO:0007049]; cell division [GO:0051301]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]	cullin family protein binding [GO:0097602]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; cullin family protein binding [GO:0097602]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465]	
Q9P2P5	reviewed	HECW2_HUMAN	E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)	HECW2 KIAA1301 NEDL2	Homo sapiens (Human)	1572	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). {ECO:0000269|PubMed:12890487, ECO:0000269|PubMed:24163370}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]; regulation of mitotic metaphase/anaphase transition [GO:0030071]	cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]; regulation of mitotic metaphase/anaphase transition [GO:0030071]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:24163370}.
Q9P2P6	reviewed	STAR9_HUMAN	StAR-related lipid transfer protein 9 (START domain-containing protein 9) (StARD9)	STARD9 KIAA1300	Homo sapiens (Human)	4700	FUNCTION: Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM). {ECO:0000269|PubMed:22153075}.		microtubule-based movement [GO:0007018]; spindle assembly [GO:0051225]	centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22153075}. Nucleus {ECO:0000269|PubMed:22153075}. Note=Localizes throughout the cytoplasm and nucleus during interphase. Localizes to the daughter centriole during mitosis. Disappears in cytokinesis.
Q9P2Q2	reviewed	FRM4A_HUMAN	FERM domain-containing protein 4A	FRMD4A FRMD4 KIAA1294	Homo sapiens (Human)	1039	FUNCTION: Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}.		establishment of epithelial cell polarity [GO:0090162]; negative regulation of protein secretion [GO:0050709]; positive regulation of protein secretion [GO:0050714]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	protein-macromolecule adaptor activity [GO:0030674]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; protein-macromolecule adaptor activity [GO:0030674]; establishment of epithelial cell polarity [GO:0090162]; negative regulation of protein secretion [GO:0050709]; positive regulation of protein secretion [GO:0050714]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q8BIE6}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q8BIE6}. Note=Colocalized with CYTH1 at adherens junction and tight junction. Colocalized with PARD3 during the process of epithelial polarization. {ECO:0000250|UniProtKB:Q8BIE6}.
Q9P2R3	reviewed	ANFY1_HUMAN	Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif)	ANKFY1 ANKHZN KIAA1255	Homo sapiens (Human)	1169	FUNCTION: Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051, ECO:0000269|PubMed:24102721}.		endocytosis [GO:0006897]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; Golgi to lysosome transport [GO:0090160]; positive regulation of pinocytosis [GO:0048549]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; macropinosome [GO:0044354]; membrane [GO:0016020]	metal ion binding [GO:0046872]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; macropinosome [GO:0044354]; membrane [GO:0016020]; metal ion binding [GO:0046872]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; Golgi to lysosome transport [GO:0090160]; positive regulation of pinocytosis [GO:0048549]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10940552}. Endosome membrane {ECO:0000269|PubMed:10940552}; Peripheral membrane protein {ECO:0000269|PubMed:10940552}. Early endosome {ECO:0000269|PubMed:15328530}. Note=Also associated with endosomal membranes. Localizes to macropinosomes. {ECO:0000269|PubMed:15328530}.
Q9P2R6	reviewed	RERE_HUMAN	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein)	RERE ARG ARP ATN1L KIAA0458	Homo sapiens (Human)	1566	FUNCTION: Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}.		branching morphogenesis of a nerve [GO:0048755]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellar Purkinje cell layer maturation [GO:0021691]; chromatin remodeling [GO:0006338]; dendrite morphogenesis [GO:0048813]; radial glia guided migration of Purkinje cell [GO:0021942]	histone deacetylase complex [GO:0000118]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	histone deacetylase complex [GO:0000118]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; branching morphogenesis of a nerve [GO:0048755]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellar Purkinje cell layer maturation [GO:0021691]; chromatin remodeling [GO:0006338]; dendrite morphogenesis [GO:0048813]; radial glia guided migration of Purkinje cell [GO:0021942]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10814707, ECO:0000269|PubMed:11331249}. Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.
Q9P2R7	reviewed	SUCB1_HUMAN	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)	SUCLA2	Homo sapiens (Human)	463	FUNCTION: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity). {ECO:0000255|HAMAP-Rule:MF_03220, ECO:0000269|PubMed:15877282}.		succinate metabolic process [GO:0006105]; succinyl-CoA catabolic process [GO:1901289]; succinyl-CoA metabolic process [GO:0006104]; succinyl-CoA pathway [GO:0006781]; tricarboxylic acid cycle [GO:0006099]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; succinate-CoA ligase complex [GO:0042709]; succinate-CoA ligase complex (ADP-forming) [GO:0009361]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; succinate-CoA ligase complex [GO:0042709]; succinate-CoA ligase complex (ADP-forming) [GO:0009361]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinate metabolic process [GO:0006105]; succinyl-CoA catabolic process [GO:1901289]; succinyl-CoA metabolic process [GO:0006104]; succinyl-CoA pathway [GO:0006781]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03220, ECO:0000269|PubMed:15877282, ECO:0000269|PubMed:17287286, ECO:0000269|PubMed:25944712}.
Q9P2S2	reviewed	NRX2A_HUMAN	Neurexin-2 (Neurexin II-alpha) (Neurexin-2-alpha)	NRXN2 KIAA0921	Homo sapiens (Human)	1712	FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.		adult behavior [GO:0030534]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter secretion [GO:0007269]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; signal transduction [GO:0007165]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]	cell projection [GO:0042995]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]	calcium channel regulator activity [GO:0005246]; cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; transmembrane signaling receptor activity [GO:0004888]	cell projection [GO:0042995]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; calcium channel regulator activity [GO:0005246]; cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; transmembrane signaling receptor activity [GO:0004888]; adult behavior [GO:0030534]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter secretion [GO:0007269]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; signal transduction [GO:0007165]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9CS84}; Single-pass type I membrane protein {ECO:0000255}.
Q9P2S5	reviewed	WRP73_HUMAN	WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene)	WRAP73 WDR8	Homo sapiens (Human)	460	FUNCTION: The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238). {ECO:0000269|PubMed:26545777, ECO:0000269|PubMed:26675238}.		cell projection organization [GO:0030030]; mitotic spindle assembly [GO:0090307]; positive regulation of non-motile cilium assembly [GO:1902857]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; MWP complex [GO:1990811]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; MWP complex [GO:1990811]; cell projection organization [GO:0030030]; mitotic spindle assembly [GO:0090307]; positive regulation of non-motile cilium assembly [GO:1902857]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:26545777, ECO:0000269|PubMed:26675238}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26675238}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26675238}. Note=Enriched in the proximal end of the mother centriole (PubMed:26545777). During ciliogenesis also associated with the basal body of the adjacent centriole (PubMed:26675238). {ECO:0000269|PubMed:26545777, ECO:0000269|PubMed:26675238}.
Q9P2T0	reviewed	SPMA2_HUMAN	Sperm microtubule associated protein 2 (Cancer/testis antigen 56) (CT56) (Testicular haploid expressed gene protein)	SPMAP2 THEG	Homo sapiens (Human)	379	FUNCTION: May be involved (but not essential) in spermatogenesis. {ECO:0000250|UniProtKB:Q9JMB1}.		cell differentiation [GO:0030154]; chaperone-mediated protein complex assembly [GO:0051131]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]		nucleus [GO:0005634]; cell differentiation [GO:0030154]; chaperone-mediated protein complex assembly [GO:0051131]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JMB1}. Note=Localized predominantly in the nucleus of haploid round spermatid. {ECO:0000250|UniProtKB:Q9JMB1}.
Q9P2T1	reviewed	GMPR2_HUMAN	GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)	GMPR2	Homo sapiens (Human)	348	FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231). {ECO:0000255|HAMAP-Rule:MF_03195, ECO:0000269|PubMed:12009299, ECO:0000269|PubMed:12669231, ECO:0000269|PubMed:16359702, ECO:0000269|PubMed:22037469}.		GMP metabolic process [GO:0046037]; purine nucleobase metabolic process [GO:0006144]	cytosol [GO:0005829]; GMP reductase complex [GO:1902560]	GMP reductase activity [GO:0003920]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; GMP reductase complex [GO:1902560]; GMP reductase activity [GO:0003920]; metal ion binding [GO:0046872]; GMP metabolic process [GO:0046037]; purine nucleobase metabolic process [GO:0006144]	
Q9P2U7	reviewed	VGLU1_HUMAN	Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7)	SLC17A7 BNPI VGLUT1	Homo sapiens (Human)	560	FUNCTION: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (By similarity). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular K(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:10820226). The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity). {ECO:0000250|UniProtKB:Q3TXX4, ECO:0000250|UniProtKB:Q62634, ECO:0000269|PubMed:10820226}.		chloride transport [GO:0006821]; L-glutamate transmembrane transport [GO:0015813]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; neural retina development [GO:0003407]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter transport [GO:0006836]; phosphate ion homeostasis [GO:0055062]; phosphate ion transport [GO:0006817]; potassium ion transport [GO:0006813]; regulation of synapse structure or activity [GO:0050803]; regulation of synaptic vesicle endocytosis [GO:1900242]; sodium-dependent phosphate transport [GO:0044341]; synaptic transmission, glutamatergic [GO:0035249]	chloride channel complex [GO:0034707]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; excitatory synapse [GO:0060076]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; synaptic vesicle membrane [GO:0030672]	chloride channel activity [GO:0005254]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamate uniporter activity [GO:0140788]; neurotransmitter transmembrane transporter activity [GO:0005326]; phosphate ion uniporter activity [GO:0140787]; potassium:proton antiporter activity [GO:0015386]; sodium:inorganic phosphate symporter activity [GO:0015319]; sodium:phosphate symporter activity [GO:0005436]	chloride channel complex [GO:0034707]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; excitatory synapse [GO:0060076]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; synaptic vesicle membrane [GO:0030672]; chloride channel activity [GO:0005254]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamate uniporter activity [GO:0140788]; neurotransmitter transmembrane transporter activity [GO:0005326]; phosphate ion uniporter activity [GO:0140787]; potassium:proton antiporter activity [GO:0015386]; sodium:inorganic phosphate symporter activity [GO:0015319]; sodium:phosphate symporter activity [GO:0005436]; chloride transport [GO:0006821]; L-glutamate transmembrane transport [GO:0015813]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; neural retina development [GO:0003407]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter transport [GO:0006836]; phosphate ion homeostasis [GO:0055062]; phosphate ion transport [GO:0006817]; potassium ion transport [GO:0006813]; regulation of synapse structure or activity [GO:0050803]; regulation of synaptic vesicle endocytosis [GO:1900242]; sodium-dependent phosphate transport [GO:0044341]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q3TXX4}. Cell membrane {ECO:0000305|PubMed:10820226}; Multi-pass membrane protein {ECO:0000305}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q3TXX4}.
Q9P2U8	reviewed	VGLU2_HUMAN	Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6)	SLC17A6 DNPI VGLUT2	Homo sapiens (Human)	582	FUNCTION: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:33440152, PubMed:11698620). At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:11698620). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:11698620). In addition, functions as a chloride channel that allows the chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular H(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (Probable) (PubMed:10820226). The symporter activity is driven by an inside negative membrane potential and is electrogenic (Probable). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas (By similarity). {ECO:0000250|UniProtKB:Q8BLE7, ECO:0000250|UniProtKB:Q9JI12, ECO:0000269|PubMed:10820226, ECO:0000269|PubMed:11698620, ECO:0000305|PubMed:33440152}.		hyaloid vascular plexus regression [GO:1990384]; L-glutamate import [GO:0051938]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; neurotransmitter loading into synaptic vesicle [GO:0098700]; phosphate ion homeostasis [GO:0055062]; phosphate ion transport [GO:0006817]; regulation of synapse structure or activity [GO:0050803]; sodium-dependent phosphate transport [GO:0044341]; synaptic transmission, glutamatergic [GO:0035249]	chloride channel complex [GO:0034707]; excitatory synapse [GO:0060076]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	chloride channel activity [GO:0005254]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamate uniporter activity [GO:0140788]; neurotransmitter transmembrane transporter activity [GO:0005326]; potassium:proton antiporter activity [GO:0015386]; sodium:phosphate symporter activity [GO:0005436]	chloride channel complex [GO:0034707]; excitatory synapse [GO:0060076]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; chloride channel activity [GO:0005254]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamate uniporter activity [GO:0140788]; neurotransmitter transmembrane transporter activity [GO:0005326]; potassium:proton antiporter activity [GO:0015386]; sodium:phosphate symporter activity [GO:0005436]; hyaloid vascular plexus regression [GO:1990384]; L-glutamate import [GO:0051938]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; neurotransmitter loading into synaptic vesicle [GO:0098700]; phosphate ion homeostasis [GO:0055062]; phosphate ion transport [GO:0006817]; regulation of synapse structure or activity [GO:0050803]; sodium-dependent phosphate transport [GO:0044341]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:11698620}; Multi-pass membrane protein {ECO:0000255}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q8BLE7}. Cell membrane {ECO:0000305|PubMed:33440152}; Multi-pass membrane protein {ECO:0000255}.
Q9P2W1	reviewed	HOP2_HUMAN	Homologous-pairing protein 2 homolog (Nuclear receptor coactivator GT198) (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein) (Tat-binding protein 1-interacting protein) (TBP-1-interacting protein)	PSMC3IP HOP2 TBPIP	Homo sapiens (Human)	217	FUNCTION: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. {ECO:0000269|PubMed:10806355, ECO:0000269|PubMed:16407260, ECO:0000269|PubMed:21963259}.		homologous chromosome pairing at meiosis [GO:0007129]; meiotic joint molecule formation [GO:0000709]; meiotic strand invasion involved in reciprocal meiotic recombination [GO:0010774]; reciprocal meiotic recombination [GO:0007131]	condensed nuclear chromosome [GO:0000794]; DNA recombinase auxiliary factor complex [GO:0120231]; nucleoplasm [GO:0005654]	double-stranded DNA binding [GO:0003690]; nuclear receptor coactivator activity [GO:0030374]; recombinase activator activity [GO:0120230]	condensed nuclear chromosome [GO:0000794]; DNA recombinase auxiliary factor complex [GO:0120231]; nucleoplasm [GO:0005654]; double-stranded DNA binding [GO:0003690]; nuclear receptor coactivator activity [GO:0030374]; recombinase activator activity [GO:0120230]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic joint molecule formation [GO:0000709]; meiotic strand invasion involved in reciprocal meiotic recombination [GO:0010774]; reciprocal meiotic recombination [GO:0007131]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11739747}.
Q9P2W3	reviewed	GBG13_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNG13	Homo sapiens (Human)	67	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.		G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; sensory perception of taste [GO:0050909]	dendrite [GO:0030425]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]	G-protein beta-subunit binding [GO:0031681]	dendrite [GO:0030425]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; G-protein beta-subunit binding [GO:0031681]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; sensory perception of taste [GO:0050909]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q9P2W7	reviewed	B3GA1_HUMAN	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 1) (Glucuronosyltransferase P) (GlcAT-P) (UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase) (GlcUAT-P)	B3GAT1 GLCATP	Homo sapiens (Human)	334	FUNCTION: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. {ECO:0000250|UniProtKB:O35789}.		carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; visual learning [GO:0008542]	endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018]; metal ion binding [GO:0046872]	endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018]; metal ion binding [GO:0046872]; carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000250|UniProtKB:O35789}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O35789}. Secreted {ECO:0000250|UniProtKB:O35789}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane {ECO:0000250|UniProtKB:O35789}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O35789}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O35789}. Secreted {ECO:0000250|UniProtKB:O35789}.
Q9P2W9	reviewed	STX18_HUMAN	Syntaxin-18 (Cell growth-inhibiting gene 9 protein)	STX18 GIG9	Homo sapiens (Human)	335	FUNCTION: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15029241}.		endoplasmic reticulum membrane organization [GO:0090158]; intracellular protein transport [GO:0006886]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of organelle assembly [GO:1902117]; regulation of Golgi organization [GO:1903358]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; SNARE complex [GO:0031201]	protein domain specific binding [GO:0019904]; SNAP receptor activity [GO:0005484]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; SNARE complex [GO:0031201]; protein domain specific binding [GO:0019904]; SNAP receptor activity [GO:0005484]; endoplasmic reticulum membrane organization [GO:0090158]; intracellular protein transport [GO:0006886]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of organelle assembly [GO:1902117]; regulation of Golgi organization [GO:1903358]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:15029241}; Single-pass type IV membrane protein {ECO:0000305|PubMed:15029241}. Golgi apparatus membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Q9P2X0	reviewed	DPM3_HUMAN	Dolichol-phosphate mannosyltransferase subunit 3 (Dolichol-phosphate mannose synthase subunit 3) (DPM synthase subunit 3) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 3) (Mannose-P-dolichol synthase subunit 3) (MPD synthase subunit 3) (Prostin-1)	DPM3	Homo sapiens (Human)	92	FUNCTION: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the endoplasmic reticulum. {ECO:0000269|PubMed:10835346}.		carbohydrate metabolic process [GO:0005975]; dolichol metabolic process [GO:0019348]; GPI anchor biosynthetic process [GO:0006506]; protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan [GO:0018406]; protein mannosylation [GO:0035268]; protein O-linked mannosylation [GO:0035269]; regulation of protein stability [GO:0031647]	dolichol-phosphate-mannose synthase complex [GO:0033185]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mannosyltransferase complex [GO:0031501]; membrane [GO:0016020]	enzyme activator activity [GO:0008047]	dolichol-phosphate-mannose synthase complex [GO:0033185]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mannosyltransferase complex [GO:0031501]; membrane [GO:0016020]; enzyme activator activity [GO:0008047]; carbohydrate metabolic process [GO:0005975]; dolichol metabolic process [GO:0019348]; GPI anchor biosynthetic process [GO:0006506]; protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan [GO:0018406]; protein mannosylation [GO:0035268]; protein O-linked mannosylation [GO:0035269]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Q9P2X3	reviewed	IMPCT_HUMAN	Protein IMPACT (Imprinted and ancient gene protein homolog)	IMPACT	Homo sapiens (Human)	320	FUNCTION: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. {ECO:0000250|UniProtKB:O55091}.	MISCELLANEOUS: In contrast to the mouse or rabbit ortholog, the IMPACT locus is not imprinted in human.	cellular response to amino acid starvation [GO:0034198]; cellular response to leucine starvation [GO:1990253]; GCN2-mediated signaling [GO:0140469]; intracellular signal transduction [GO:0035556]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron projection extension [GO:1990138]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of translational initiation in response to starvation [GO:0071264]; regulation of cytoplasmic translational initiation in response to stress [GO:1990611]; regulation of translational initiation [GO:0006446]	cytoplasm [GO:0005737]; polysome [GO:0005844]	actin binding [GO:0003779]; protein sequestering activity [GO:0140311]; ribosome binding [GO:0043022]	cytoplasm [GO:0005737]; polysome [GO:0005844]; actin binding [GO:0003779]; protein sequestering activity [GO:0140311]; ribosome binding [GO:0043022]; cellular response to amino acid starvation [GO:0034198]; cellular response to leucine starvation [GO:1990253]; GCN2-mediated signaling [GO:0140469]; intracellular signal transduction [GO:0035556]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron projection extension [GO:1990138]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of translational initiation in response to starvation [GO:0071264]; regulation of cytoplasmic translational initiation in response to stress [GO:1990611]; regulation of translational initiation [GO:0006446]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O55091}.
Q9P2Y4	reviewed	ZN219_HUMAN	Zinc finger protein 219	ZNF219	Homo sapiens (Human)	722	FUNCTION: Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q6IQX8, ECO:0000269|PubMed:14621294, ECO:0000269|PubMed:19549071}.		limb bud formation [GO:0060174]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of neurotransmitter levels [GO:0001505]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histamine receptor activity [GO:0004969]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histamine receptor activity [GO:0004969]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; limb bud formation [GO:0060174]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of neurotransmitter levels [GO:0001505]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10819330, ECO:0000269|PubMed:14621294}.
Q9P2Y5	reviewed	UVRAG_HUMAN	UV radiation resistance-associated gene protein (p63)	UVRAG	Homo sapiens (Human)	699	FUNCTION: Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}.		autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; centrosome cycle [GO:0007098]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; maintenance of Golgi location [GO:0051684]; multivesicular body sorting pathway [GO:0071985]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of autophagosome maturation [GO:1901098]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of protein serine/threonine kinase activity [GO:0071900]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; SNARE complex assembly [GO:0035493]; spindle organization [GO:0007051]; viral entry into host cell [GO:0046718]	autophagosome membrane [GO:0000421]; centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; late endosome [GO:0005770]; lysosome [GO:0005764]; lytic vacuole [GO:0000323]; midbody [GO:0030496]; phagocytic vesicle [GO:0045335]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]	SH3 domain binding [GO:0017124]; SNARE binding [GO:0000149]	autophagosome membrane [GO:0000421]; centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; late endosome [GO:0005770]; lysosome [GO:0005764]; lytic vacuole [GO:0000323]; midbody [GO:0030496]; phagocytic vesicle [GO:0045335]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; SH3 domain binding [GO:0017124]; SNARE binding [GO:0000149]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; centrosome cycle [GO:0007098]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; maintenance of Golgi location [GO:0051684]; multivesicular body sorting pathway [GO:0071985]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of autophagosome maturation [GO:1901098]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of protein serine/threonine kinase activity [GO:0071900]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; SNARE complex assembly [GO:0035493]; spindle organization [GO:0007051]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:18843052}. Lysosome {ECO:0000269|PubMed:18843052}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:28306502}. Early endosome {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:18843052}. Endoplasmic reticulum {ECO:0000269|PubMed:24056303}. Midbody {ECO:0000269|PubMed:20643123}. Chromosome, centromere {ECO:0000269|PubMed:22542840}. Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial (PubMed:24056303). Recruited to autophagosome following interaction with RUBCNL/PACER (PubMed:28306502). {ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502}.
Q9UBB4	reviewed	ATX10_HUMAN	Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein)	ATXN10 SCA10	Homo sapiens (Human)	475	FUNCTION: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. {ECO:0000250}.		cilium assembly [GO:0060271]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cilium assembly [GO:0060271]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:16498633}.
Q9UBB5	reviewed	MBD2_HUMAN	Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2)	MBD2	Homo sapiens (Human)	411	FUNCTION: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568). {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}.	MISCELLANEOUS: [Isoform 3]: Incomplete sequence. {ECO:0000305}.	cellular response to organic cyclic compound [GO:0071407]; chromatin remodeling [GO:0006338]; DNA methylation-dependent heterochromatin formation [GO:0006346]; embryonic organ development [GO:0048568]; heart development [GO:0007507]; maternal behavior [GO:0042711]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Wnt signaling pathway [GO:0030177]; protein-containing complex assembly [GO:0065003]; regulation of cell population proliferation [GO:0042127]; regulation of DNA methylation [GO:0044030]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]	C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; satellite DNA binding [GO:0003696]; siRNA binding [GO:0035197]	chromatin [GO:0000785]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; satellite DNA binding [GO:0003696]; siRNA binding [GO:0035197]; cellular response to organic cyclic compound [GO:0071407]; chromatin remodeling [GO:0006338]; DNA methylation-dependent heterochromatin formation [GO:0006346]; embryonic organ development [GO:0048568]; heart development [GO:0007507]; maternal behavior [GO:0042711]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Wnt signaling pathway [GO:0030177]; protein-containing complex assembly [GO:0065003]; regulation of cell population proliferation [GO:0042127]; regulation of DNA methylation [GO:0044030]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:15701600, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408, ECO:0000269|PubMed:9774669}. Chromosome {ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:27732854}. Note=Nuclear, in discrete foci (PubMed:12183469). Detected at replication foci in late S phase. Localizes to methylated chromatin (PubMed:16428440). Localizes to sites of DNA damage in a manner partially dependent on ZMYND8 (PubMed:27732854). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:27732854}.
Q9UBB6	reviewed	NCDN_HUMAN	Neurochondrin	NCDN KIAA0607	Homo sapiens (Human)	729	FUNCTION: Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable). {ECO:0000269|PubMed:16945926, ECO:0000269|PubMed:33711248, ECO:0000305|PubMed:33711248}.		bone resorption [GO:0045453]; neuron projection development [GO:0031175]; regulation of neuronal synaptic plasticity [GO:0048168]	cytosol [GO:0005829]; dendrite [GO:0030425]; endosome membrane [GO:0010008]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; postsynapse [GO:0098794]		cytosol [GO:0005829]; dendrite [GO:0030425]; endosome membrane [GO:0010008]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; bone resorption [GO:0045453]; neuron projection development [GO:0031175]; regulation of neuronal synaptic plasticity [GO:0048168]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23687301}. Endosome membrane {ECO:0000250|UniProtKB:O35095}; Lipid-anchor {ECO:0000305|PubMed:23687301}. Cell projection, dendrite {ECO:0000250|UniProtKB:O35095}. Postsynapse {ECO:0000250|UniProtKB:O35095}. Note=Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation. {ECO:0000250|UniProtKB:O35095}.
Q9UBB9	reviewed	TFP11_HUMAN	Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1)	TFIP11 STIP HSPC006	Homo sapiens (Human)	837	FUNCTION: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}.		biomineral tissue development [GO:0031214]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA ligase activity [GO:1904876]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; negative regulation of protein binding [GO:0032091]; negative regulation of protein-containing complex assembly [GO:0031333]; protection from non-homologous end joining at telomere [GO:0031848]; RNA processing [GO:0006396]; spliceosomal complex disassembly [GO:0000390]	catalytic step 2 spliceosome [GO:0071013]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2-type post-mRNA release spliceosomal complex [GO:0071008]	nucleic acid binding [GO:0003676]	catalytic step 2 spliceosome [GO:0071013]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2-type post-mRNA release spliceosomal complex [GO:0071008]; nucleic acid binding [GO:0003676]; biomineral tissue development [GO:0031214]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA ligase activity [GO:1904876]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; negative regulation of protein binding [GO:0032091]; negative regulation of protein-containing complex assembly [GO:0031333]; protection from non-homologous end joining at telomere [GO:0031848]; RNA processing [GO:0006396]; spliceosomal complex disassembly [GO:0000390]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles. {ECO:0000250}.
Q9UBC0	reviewed	HNF6_HUMAN	Hepatocyte nuclear factor 6 (HNF-6) (One cut domain family member 1) (One cut homeobox 1)	ONECUT1 HNF6 HNF6A	Homo sapiens (Human)	465	FUNCTION: Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.		anatomical structure morphogenesis [GO:0009653]; B cell differentiation [GO:0030183]; cell fate commitment [GO:0045165]; cell migration [GO:0016477]; cilium assembly [GO:0060271]; endoderm development [GO:0007492]; epithelial cell development [GO:0002064]; glucose metabolic process [GO:0006006]; liver development [GO:0001889]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; Notch signaling pathway [GO:0007219]; pancreatic A cell differentiation [GO:0003310]; pancreatic D cell differentiation [GO:0003311]; positive regulation of cell migration [GO:0030335]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell-matrix adhesion [GO:0001952]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spleen development [GO:0048536]; transforming growth factor beta receptor signaling pathway [GO:0007179]; type B pancreatic cell differentiation [GO:0003309]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; B cell differentiation [GO:0030183]; cell fate commitment [GO:0045165]; cell migration [GO:0016477]; cilium assembly [GO:0060271]; endoderm development [GO:0007492]; epithelial cell development [GO:0002064]; glucose metabolic process [GO:0006006]; liver development [GO:0001889]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; Notch signaling pathway [GO:0007219]; pancreatic A cell differentiation [GO:0003310]; pancreatic D cell differentiation [GO:0003311]; positive regulation of cell migration [GO:0030335]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell-matrix adhesion [GO:0001952]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spleen development [GO:0048536]; transforming growth factor beta receptor signaling pathway [GO:0007179]; type B pancreatic cell differentiation [GO:0003309]	SUBCELLULAR LOCATION: Nucleus.
Q9UBC1	reviewed	IKBL1_HUMAN	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1)	NFKBIL1 IKBL	Homo sapiens (Human)	381	FUNCTION: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. {ECO:0000269|PubMed:20829348}.		canonical NF-kappaB signal transduction [GO:0007249]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20829348}. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus.
Q9UBC2	reviewed	EP15R_HUMAN	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)	EPS15L1 EPS15R	Homo sapiens (Human)	864	FUNCTION: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}.		endocytosis [GO:0006897]; endosomal transport [GO:0016197]	clathrin coat of coated pit [GO:0030132]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	clathrin coat of coated pit [GO:0030132]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Membrane, coated pit {ECO:0000250}. Note=Localized to plasma membrane coated pits. {ECO:0000250}.
Q9UBC3	reviewed	DNM3B_HUMAN	DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB)	DNMT3B	Homo sapiens (Human)	853	FUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). {ECO:0000250, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:17303076, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18567530, ECO:0000269|PubMed:27153398}.		C-5 methylation of cytosine [GO:0090116]; DNA methylation [GO:0006306]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]	catalytic complex [GO:1902494]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [GO:0051718]; DNA binding [GO:0003677]; DNA-methyltransferase activity [GO:0009008]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	catalytic complex [GO:1902494]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [GO:0051718]; DNA binding [GO:0003677]; DNA-methyltransferase activity [GO:0009008]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; C-5 methylation of cytosine [GO:0090116]; DNA methylation [GO:0006306]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11735126, ECO:0000269|PubMed:12145218}.
Q9UBC5	reviewed	MYO1A_HUMAN	Unconventional myosin-Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC)	MYO1A MYHL	Homo sapiens (Human)	1043	FUNCTION: Involved in directing the movement of organelles along actin filaments. {ECO:0000305}.		actin filament organization [GO:0007015]; microvillus assembly [GO:0030033]; sensory perception of sound [GO:0007605]; vesicle localization [GO:0051648]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; lateral plasma membrane [GO:0016328]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; lateral plasma membrane [GO:0016328]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; actin filament organization [GO:0007015]; microvillus assembly [GO:0030033]; sensory perception of sound [GO:0007605]; vesicle localization [GO:0051648]; vesicle transport along actin filament [GO:0030050]	
Q9UBC7	reviewed	GALP_HUMAN	Galanin-like peptide	GALP	Homo sapiens (Human)	116	FUNCTION: [Isoform 1]: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.; FUNCTION: [Isoform 2]: Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed:23537644). {ECO:0000269|PubMed:23537644}.	MISCELLANEOUS: [Isoform 2]: Cleavage of the signal peptide generates a peptide of 25 amino acids, termed alarin because of the N-terminal alanine and the C-terminal serine. Involved in ganglionic differentiation in neuroblastic tumor tissues. Vasoactive peptide. {ECO:0000305}.	antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; behavioral response to starvation [GO:0042595]; defense response to Gram-negative bacterium [GO:0050829]; modulation of process of another organism [GO:0035821]; neuropeptide signaling pathway [GO:0007218]; regulation of appetite [GO:0032098]; response to insulin [GO:0032868]	extracellular region [GO:0005576]	hormone activity [GO:0005179]	extracellular region [GO:0005576]; hormone activity [GO:0005179]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; behavioral response to starvation [GO:0042595]; defense response to Gram-negative bacterium [GO:0050829]; modulation of process of another organism [GO:0035821]; neuropeptide signaling pathway [GO:0007218]; regulation of appetite [GO:0032098]; response to insulin [GO:0032868]	SUBCELLULAR LOCATION: Secreted.
Q9UBC9	reviewed	SPRR3_HUMAN	Small proline-rich protein 3 (22 kDa pancornulin) (Cornifin beta) (Esophagin)	SPRR3 SPRC	Homo sapiens (Human)	169	FUNCTION: Cross-linked envelope protein of keratinocytes.		epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; wound healing [GO:0042060]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]	structural molecule activity [GO:0005198]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; structural molecule activity [GO:0005198]; epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm.
Q9UBD0	reviewed	HSFX1_HUMAN	Heat shock transcription factor, X-linked	HSFX1 LW-1; HSFX2	Homo sapiens (Human)	423			regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:15044259}.
Q9UBD3	reviewed	XCL2_HUMAN	Cytokine SCM-1 beta (C motif chemokine 2) (XC chemokine ligand 2)	XCL2 SCYC2	Homo sapiens (Human)	114	FUNCTION: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. {ECO:0000250}.		blood circulation [GO:0008015]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of T cell chemotaxis [GO:0010820]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; blood circulation [GO:0008015]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of T cell chemotaxis [GO:0010820]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
Q9UBD5	reviewed	ORC3_HUMAN	Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo)	ORC3 LATHEO ORC3L	Homo sapiens (Human)	711	FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:31160578}.		DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; glial cell proliferation [GO:0014009]; neural precursor cell proliferation [GO:0061351]; regulation of DNA replication [GO:0006275]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; DNA replication preinitiation complex [GO:0031261]; nuclear body [GO:0016604]; nuclear origin of replication recognition complex [GO:0005664]; nuclear pre-replicative complex [GO:0005656]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]	DNA replication origin binding [GO:0003688]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; DNA replication preinitiation complex [GO:0031261]; nuclear body [GO:0016604]; nuclear origin of replication recognition complex [GO:0005664]; nuclear pre-replicative complex [GO:0005656]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]; DNA replication origin binding [GO:0003688]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; glial cell proliferation [GO:0014009]; neural precursor cell proliferation [GO:0061351]; regulation of DNA replication [GO:0006275]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31160578}. Chromosome {ECO:0000269|PubMed:31160578}.
Q9UBD6	reviewed	RHCG_HUMAN	Ammonium transporter Rh type C (Rh glycoprotein kidney) (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein) (Tumor-related protein DRC2)	RHCG C15orf6 CDRC2 PDRC2 RHGK	Homo sapiens (Human)	479	FUNCTION: Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (PubMed:11062476, PubMed:14761968, PubMed:15929723, PubMed:16477434, PubMed:16580862, PubMed:24077989). May act as a CO2 channel providing for renal acid secretion (PubMed:24077989). {ECO:0000269|PubMed:11062476, ECO:0000269|PubMed:14761968, ECO:0000269|PubMed:15929723, ECO:0000269|PubMed:16477434, ECO:0000269|PubMed:16580862, ECO:0000269|PubMed:24077989}.		amine transport [GO:0015837]; ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]; epithelial cell differentiation [GO:0030855]; homeostatic process [GO:0042592]; intracellular monoatomic ion homeostasis [GO:0006873]; regulation of pH [GO:0006885]; transepithelial ammonium transport [GO:0070634]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	ammonium transmembrane transporter activity [GO:0008519]; ankyrin binding [GO:0030506]; carbon dioxide transmembrane transporter activity [GO:0035379]; identical protein binding [GO:0042802]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; ammonium transmembrane transporter activity [GO:0008519]; ankyrin binding [GO:0030506]; carbon dioxide transmembrane transporter activity [GO:0035379]; identical protein binding [GO:0042802]; amine transport [GO:0015837]; ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]; epithelial cell differentiation [GO:0030855]; homeostatic process [GO:0042592]; intracellular monoatomic ion homeostasis [GO:0006873]; regulation of pH [GO:0006885]; transepithelial ammonium transport [GO:0070634]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15929723}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:10852913, ECO:0000269|PubMed:12204676}; Multi-pass membrane protein {ECO:0000255}. Note=Also detected at the basolateral membrane and in subapical vesicles. {ECO:0000250}.
Q9UBD9	reviewed	CLCF1_HUMAN	Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3) (BSF-3) (Novel neurotrophin-1) (NNT-1)	CLCF1 BSF3 CLC NNT1	Homo sapiens (Human)	225	FUNCTION: In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor. {ECO:0000269|PubMed:10448081, ECO:0000269|PubMed:10500198, ECO:0000305|PubMed:26858303}.		B cell differentiation [GO:0030183]; cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of isotype switching to IgE isotypes [GO:0048295]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via JAK-STAT [GO:0007259]	CNTFR-CLCF1 complex [GO:0097059]; CRLF-CLCF1 complex [GO:0097058]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102]	CNTFR-CLCF1 complex [GO:0097059]; CRLF-CLCF1 complex [GO:0097058]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102]; B cell differentiation [GO:0030183]; cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of isotype switching to IgE isotypes [GO:0048295]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via JAK-STAT [GO:0007259]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q9UBE0	reviewed	SAE1_HUMAN	SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]	SAE1 AOS1 SUA1 UBLE1A	Homo sapiens (Human)	346	FUNCTION: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}.		positive regulation of protein sumoylation [GO:0033235]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein sumoylation [GO:0016925]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SUMO activating enzyme complex [GO:0031510]	ATP-dependent protein binding [GO:0043008]; enzyme activator activity [GO:0008047]; protein heterodimerization activity [GO:0046982]; small protein activating enzyme binding [GO:0044388]; ubiquitin activating enzyme activity [GO:0004839]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SUMO activating enzyme complex [GO:0031510]; ATP-dependent protein binding [GO:0043008]; enzyme activator activity [GO:0008047]; protein heterodimerization activity [GO:0046982]; small protein activating enzyme binding [GO:0044388]; ubiquitin activating enzyme activity [GO:0004839]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein sumoylation [GO:0016925]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11481243}.
Q9UBE8	reviewed	NLK_HUMAN	Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1)	NLK LAK1	Homo sapiens (Human)	527	FUNCTION: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination (PubMed:14960582, PubMed:12482967, PubMed:15004007, PubMed:15764709, PubMed:20061393, PubMed:20874444, PubMed:21454679). Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2 (PubMed:15004007, PubMed:15764709). Negative regulator of the canonical Wnt/beta-catenin signaling pathway (PubMed:12482967). Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1 (PubMed:21454679). Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes (PubMed:12482967, PubMed:21454679). Negative regulator of the Notch signaling pathway (PubMed:20118921). Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1 (PubMed:20118921). Negative regulator of the MYB family of transcription factors (PubMed:15082531). Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP (PubMed:15082531). Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself (PubMed:15082531). Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (PubMed:15004007, PubMed:15764709). Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613). Acts as an inhibitor of the mTORC1 complex in response to osmotic stress by mediating phosphorylation of RPTOR, thereby preventing recruitment of the mTORC1 complex to lysosomes (PubMed:26588989). {ECO:0000269|PubMed:12482967, ECO:0000269|PubMed:14960582, ECO:0000269|PubMed:15004007, ECO:0000269|PubMed:15082531, ECO:0000269|PubMed:15764709, ECO:0000269|PubMed:20061393, ECO:0000269|PubMed:20118921, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:25512613, ECO:0000269|PubMed:26588989}.		cellular response to osmotic stress [GO:0071470]; intracellular signal transduction [GO:0035556]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of Wnt signaling pathway [GO:0030178]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; serine phosphorylation of STAT protein [GO:0042501]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; SH2 domain binding [GO:0042169]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; SH2 domain binding [GO:0042169]; ubiquitin protein ligase binding [GO:0031625]; cellular response to osmotic stress [GO:0071470]; intracellular signal transduction [GO:0035556]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of Wnt signaling pathway [GO:0030178]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; serine phosphorylation of STAT protein [GO:0042501]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O54949}. Cytoplasm {ECO:0000250|UniProtKB:O54949}. Note=Predominantly nuclear. A smaller fraction is cytoplasmic. {ECO:0000250|UniProtKB:O54949}.
Q9UBF1	reviewed	MAGC2_HUMAN	Melanoma-associated antigen C2 (Cancer/testis antigen 10) (CT10) (Hepatocellular carcinoma-associated antigen 587) (MAGE-C2 antigen) (MAGE-E1 antigen)	MAGEC2 HCA587 MAGEE1	Homo sapiens (Human)	373	FUNCTION: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein catabolic process [GO:0030163]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin protein ligase binding [GO:0031625]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein catabolic process [GO:0030163]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12920247}. Nucleus {ECO:0000269|PubMed:12920247}. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma.
Q9UBF2	reviewed	COPG2_HUMAN	Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP)	COPG2	Homo sapiens (Human)	871	FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; organelle transport along microtubule [GO:0072384]; protein secretion [GO:0009306]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; transport vesicle [GO:0030133]	structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; transport vesicle [GO:0030133]; structural molecule activity [GO:0005198]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; organelle transport along microtubule [GO:0072384]; protein secretion [GO:0009306]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi. {ECO:0000250}.
Q9UBF6	reviewed	RBX2_HUMAN	RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)	RNF7 RBX2 ROC2 SAG	Homo sapiens (Human)	113	FUNCTION: Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. {ECO:0000250|UniProtKB:P62877, ECO:0000269|PubMed:10851089}.	MISCELLANEOUS: [Isoform 2]: Inactive. {ECO:0000305}.	post-translational protein modification [GO:0043687]; protein neddylation [GO:0045116]; protein ubiquitination [GO:0016567]; response to redox state [GO:0051775]; ubiquitin-dependent protein catabolic process [GO:0006511]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	copper ion binding [GO:0005507]; cullin family protein binding [GO:0097602]; NEDD8 ligase activity [GO:0061663]; NEDD8 transferase activity [GO:0019788]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; copper ion binding [GO:0005507]; cullin family protein binding [GO:0097602]; NEDD8 ligase activity [GO:0061663]; NEDD8 transferase activity [GO:0019788]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; post-translational protein modification [GO:0043687]; protein neddylation [GO:0045116]; protein ubiquitination [GO:0016567]; response to redox state [GO:0051775]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10082581}. Nucleus {ECO:0000269|PubMed:10082581}.
Q9UBF8	reviewed	PI4KB_HUMAN	Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII)	PI4KB PIK4CB	Homo sapiens (Human)	816	FUNCTION: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development. {ECO:0000250|UniProtKB:O08561, ECO:0000269|PubMed:10559940, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12749687, ECO:0000269|PubMed:33358777, ECO:0000269|PubMed:9405935}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:27989622, PubMed:22258260). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622). {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.; FUNCTION: (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. {ECO:0000269|PubMed:22253445}.		inner ear development [GO:0048839]; lysosome organization [GO:0007040]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum membrane [GO:0030867]	1-phosphatidylinositol 4-kinase activity [GO:0004430]; 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum membrane [GO:0030867]; 1-phosphatidylinositol 4-kinase activity [GO:0004430]; 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; inner ear development [GO:0048839]; lysosome organization [GO:0007040]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus {ECO:0000269|PubMed:22124328}. Golgi apparatus membrane {ECO:0000269|PubMed:24672044, ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:28289207}. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3 (PubMed:24672044, PubMed:27009356, PubMed:28289207). GGA2 is also involved in the recruitment (PubMed:28289207). {ECO:0000269|PubMed:24672044, ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:28289207}.
Q9UBF9	reviewed	MYOTI_HUMAN	Myotilin (57 kDa cytoskeletal protein) (Myofibrillar titin-like Ig domains protein) (Titin immunoglobulin domain protein)	MYOT TTID	Homo sapiens (Human)	498	FUNCTION: Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells. {ECO:0000269|PubMed:12499399}.		homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; muscle contraction [GO:0006936]; synapse organization [GO:0050808]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; Z disc [GO:0030018]	actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; axon guidance receptor activity [GO:0008046]; structural constituent of muscle [GO:0008307]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; Z disc [GO:0030018]; actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; axon guidance receptor activity [GO:0008046]; structural constituent of muscle [GO:0008307]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; muscle contraction [GO:0006936]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000269|PubMed:10369880}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10369880}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:16076904}. Note=Sarcomeric, also localized to the sarcolemma (PubMed:10369880). Colocalizes with MYOZ1 at the Z-lines in skeletal muscle (PubMed:16076904). {ECO:0000269|PubMed:10369880, ECO:0000269|PubMed:16076904}.
Q9UBG0	reviewed	MRC2_HUMAN	C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280)	MRC2 CLEC13E ENDO180 KIAA0709 UPARAP	Homo sapiens (Human)	1479	FUNCTION: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). {ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:12972549}.		collagen catabolic process [GO:0030574]; endocytosis [GO:0006897]; osteoblast differentiation [GO:0001649]	focal adhesion [GO:0005925]; membrane [GO:0016020]	carbohydrate binding [GO:0030246]; collagen binding [GO:0005518]; signaling receptor activity [GO:0038023]	focal adhesion [GO:0005925]; membrane [GO:0016020]; carbohydrate binding [GO:0030246]; collagen binding [GO:0005518]; signaling receptor activity [GO:0038023]; collagen catabolic process [GO:0030574]; endocytosis [GO:0006897]; osteoblast differentiation [GO:0001649]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9UBG3	reviewed	CRNN_HUMAN	Cornulin (53 kDa putative calcium-binding protein) (53 kDa squamous epithelial-induced stress protein) (58 kDa heat shock protein) (Squamous epithelial heat shock protein 53) (Tumor-related protein)	CRNN C1orf10 DRC1 PDRC1 SEP53	Homo sapiens (Human)	495	FUNCTION: Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1 (PubMed:30009832). Regulates proliferation induced by pro-inflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways (PubMed:30009832). {ECO:0000269|PubMed:30009832}.		cell-cell adhesion [GO:0098609]; cellular response to cytokine stimulus [GO:0071345]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of gene expression [GO:0010468]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; response to heat [GO:0009408]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914]; cell-cell adhesion [GO:0098609]; cellular response to cytokine stimulus [GO:0071345]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of gene expression [GO:0010468]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; response to heat [GO:0009408]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:16640557}. Note=Does not colocalize with TGM1.
Q9UBH0	reviewed	I36RA_HUMAN	Interleukin-36 receptor antagonist protein (IL-36Ra) (FIL1 delta) (IL-1-related protein 3) (IL-1RP3) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 receptor antagonist homolog 1) (IL-1ra homolog 1) (Interleukin-1-like protein 1) (IL-1L1)	IL36RN FIL1D IL1F5 IL1HY1 IL1L1 IL1RP3 UNQ1896/PRO4342	Homo sapiens (Human)	155	FUNCTION: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407}.		antifungal humoral response [GO:0019732]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of type II interferon production [GO:0032689]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; interleukin-1 receptor antagonist activity [GO:0005152]; interleukin-1 receptor binding [GO:0005149]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; interleukin-1 receptor antagonist activity [GO:0005152]; interleukin-1 receptor binding [GO:0005149]; antifungal humoral response [GO:0019732]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of type II interferon production [GO:0032689]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:32272059}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}.
Q9UBH6	reviewed	S53A1_HUMAN	Solute carrier family 53 member 1 (Phosphate exporter SLC53A1) (Protein SYG1 homolog) (Xenotropic and polytropic murine leukemia virus receptor X3) (X-receptor) (Xenotropic and polytropic retrovirus receptor 1)	XPR1 SLC53A1 SYG1 X3	Homo sapiens (Human)	696	FUNCTION: Inorganic ion transporter that mediates phosphate ion export across plasma membrane. Plays a major role in phosphate homeostasis, preventing intracellular phosphate accumulation and possible calcium phosphate precipitation, ultimately preserving calcium signaling. The molecular mechanism of phosphate transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (PubMed:23791524, PubMed:25938945, PubMed:31043717) (By similarity). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7), important intracellular signaling molecules involved in regulation of phosphate flux (PubMed:27080106). {ECO:0000250|UniProtKB:Q9Z0U0, ECO:0000269|PubMed:23791524, ECO:0000269|PubMed:25938945, ECO:0000269|PubMed:27080106, ECO:0000269|PubMed:31043717}.		cellular response to phosphate starvation [GO:0016036]; intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; response to virus [GO:0009615]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	efflux transmembrane transporter activity [GO:0015562]; inositol hexakisphosphate binding [GO:0000822]; phosphate ion transmembrane transporter activity [GO:0015114]; virus receptor activity [GO:0001618]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; efflux transmembrane transporter activity [GO:0015562]; inositol hexakisphosphate binding [GO:0000822]; phosphate ion transmembrane transporter activity [GO:0015114]; virus receptor activity [GO:0001618]; cellular response to phosphate starvation [GO:0016036]; intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23791524, ECO:0000269|PubMed:31043717}; Multi-pass membrane protein {ECO:0000255}.
Q9UBI1	reviewed	COMD3_HUMAN	COMM domain-containing protein 3 (Protein Bup) (Protein PIL)	COMMD3 BUP C10orf8	Homo sapiens (Human)	195	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:23637203, ECO:0000305|PubMed:21778237}.		sodium ion transport [GO:0006814]	extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]		extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
Q9UBI4	reviewed	STML1_HUMAN	Stomatin-like protein 1 (SLP-1) (EPB72-like protein 1) (Protein unc-24 homolog) (Stomatin-related protein) (STORP)	STOML1 SLP1 UNC24 MSTP019	Homo sapiens (Human)	398	FUNCTION: May play a role in cholesterol transfer to late endosomes (PubMed:19696025). May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation (PubMed:23082202). {ECO:0000250|UniProtKB:Q8CI66, ECO:0000269|PubMed:19696025, ECO:0000305|PubMed:23082202}.		lipid transport [GO:0006869]	late endosome membrane [GO:0031902]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]		late endosome membrane [GO:0031902]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:19696025}. Membrane raft {ECO:0000269|PubMed:19696025}. Cell membrane {ECO:0000250|UniProtKB:Q8CI66}; Single-pass type III membrane protein. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q8CI66}.
Q9UBI6	reviewed	GBG12_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNG12	Homo sapiens (Human)	72	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.		G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]	G-protein beta-subunit binding [GO:0031681]; PDZ domain binding [GO:0030165]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; G-protein beta-subunit binding [GO:0031681]; PDZ domain binding [GO:0030165]; G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q9UBJ2	reviewed	ABCD2_HUMAN	ATP-binding cassette sub-family D member 2 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy-like 1) (Adrenoleukodystrophy-related protein) (hALDR)	ABCD2 ALD1 ALDL1 ALDR ALDRP	Homo sapiens (Human)	740	FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:21145416, PubMed:29397936). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable) (PubMed:29397936). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (PubMed:21145416). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:21145416). {ECO:0000269|PubMed:21145416, ECO:0000269|PubMed:29397936, ECO:0000305|PubMed:16946495}.		fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import into peroxisome [GO:0015910]; myelin maintenance [GO:0043217]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection maintenance [GO:1990535]; peroxisome organization [GO:0007031]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of unsaturated fatty acid biosynthetic process [GO:2001280]; response to bacterium [GO:0009617]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038]	cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	ABC-type transporter activity [GO:0140359]; acyl-CoA hydrolase activity [GO:0047617]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; long-chain fatty acid transporter activity [GO:0005324]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; ABC-type transporter activity [GO:0140359]; acyl-CoA hydrolase activity [GO:0047617]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; long-chain fatty acid transporter activity [GO:0005324]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import into peroxisome [GO:0015910]; myelin maintenance [GO:0043217]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection maintenance [GO:1990535]; peroxisome organization [GO:0007031]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of unsaturated fatty acid biosynthetic process [GO:2001280]; response to bacterium [GO:0009617]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:10329405, ECO:0000269|PubMed:21145416, ECO:0000269|PubMed:29397936}; Multi-pass membrane protein {ECO:0000255}.
Q9UBK2	reviewed	PRGC1_HUMAN	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6)	PPARGC1A LEM6 PGC1 PGC1A PPARGC1	Homo sapiens (Human)	798	FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:10713165, PubMed:20005308, PubMed:21376232). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:10713165, PubMed:20005308, PubMed:21376232). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:10713165, PubMed:20005308, PubMed:21376232). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:16753578, PubMed:23142079). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (PubMed:23836911). Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). {ECO:0000250|UniProtKB:O70343, ECO:0000269|PubMed:10713165, ECO:0000269|PubMed:16753578, ECO:0000269|PubMed:20005308, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:23836911}.	MISCELLANEOUS: [Isoform B5]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform B4]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform B4-8a]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform B5-NT]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform B4-3ext]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 9]: Produced by alternative promoter usage. May be involved in gluconeogenesis, liver-specific. {ECO:0000305}.	adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; cellular respiration [GO:0045333]; cellular response to oxidative stress [GO:0034599]; circadian regulation of gene expression [GO:0032922]; digestion [GO:0007586]; energy homeostasis [GO:0097009]; fatty acid oxidation [GO:0019395]; gluconeogenesis [GO:0006094]; intracellular glucose homeostasis [GO:0001678]; mitochondrion organization [GO:0007005]; mRNA processing [GO:0006397]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of smooth muscle cell proliferation [GO:0048662]; neuron apoptotic process [GO:0051402]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of cellular respiration [GO:1901857]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of gene expression [GO:0010628]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of histone acetylation [GO:0035066]; positive regulation of mitochondrial DNA metabolic process [GO:1901860]; positive regulation of mitochondrion organization [GO:0010822]; positive regulation of muscle tissue development [GO:1901863]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; protein-containing complex assembly [GO:0065003]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; respiratory electron transport chain [GO:0022904]; response to dietary excess [GO:0002021]; response to muscle activity [GO:0014850]; response to starvation [GO:0042594]; RNA splicing [GO:0008380]; temperature homeostasis [GO:0001659]; transcription initiation at RNA polymerase II promoter [GO:0006367]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; lncRNA binding [GO:0106222]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase binding [GO:0031625]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; lncRNA binding [GO:0106222]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase binding [GO:0031625]; adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; cellular respiration [GO:0045333]; cellular response to oxidative stress [GO:0034599]; circadian regulation of gene expression [GO:0032922]; digestion [GO:0007586]; energy homeostasis [GO:0097009]; fatty acid oxidation [GO:0019395]; gluconeogenesis [GO:0006094]; intracellular glucose homeostasis [GO:0001678]; mitochondrion organization [GO:0007005]; mRNA processing [GO:0006397]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of smooth muscle cell proliferation [GO:0048662]; neuron apoptotic process [GO:0051402]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of cellular respiration [GO:1901857]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of gene expression [GO:0010628]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of histone acetylation [GO:0035066]; positive regulation of mitochondrial DNA metabolic process [GO:1901860]; positive regulation of mitochondrion organization [GO:0010822]; positive regulation of muscle tissue development [GO:1901863]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; protein-containing complex assembly [GO:0065003]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; respiratory electron transport chain [GO:0022904]; response to dietary excess [GO:0002021]; response to muscle activity [GO:0014850]; response to starvation [GO:0042594]; RNA splicing [GO:0008380]; temperature homeostasis [GO:0001659]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:10713165}. Nucleus, PML body {ECO:0000250|UniProtKB:O70343}.; SUBCELLULAR LOCATION: [Isoform B4]: Nucleus {ECO:0000269|PubMed:22589246}.; SUBCELLULAR LOCATION: [Isoform B4-8a]: Cytoplasm {ECO:0000269|PubMed:22589246}. Nucleus {ECO:0000269|PubMed:22589246}.; SUBCELLULAR LOCATION: [Isoform B5]: Nucleus {ECO:0000269|PubMed:22589246}. Nucleus, PML body {ECO:0000269|PubMed:22589246}.; SUBCELLULAR LOCATION: [Isoform 9]: Nucleus {ECO:0000269|PubMed:22009745}.
Q9UBK5	reviewed	HCST_HUMAN	Hematopoietic cell signal transducer (DNAX-activation protein 10) (Membrane protein DAP10) (Transmembrane adapter protein KAP10)	HCST DAP10 KAP10 PIK3AP UNQ587/PRO1157	Homo sapiens (Human)	93	FUNCTION: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells. {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:10528161, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:12740575, ECO:0000269|PubMed:12740576, ECO:0000269|PubMed:16002667, ECO:0000269|PubMed:16339517, ECO:0000269|PubMed:16582911, ECO:0000269|PubMed:18097042}.	MISCELLANEOUS: Silencing of HCST suppresses cytolytic activity of T-cells and NK cells.	positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein phosphorylation [GO:0006468]; regulation of immune response [GO:0050776]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	phosphatidylinositol 3-kinase binding [GO:0043548]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; phosphatidylinositol 3-kinase binding [GO:0043548]; signaling receptor binding [GO:0005102]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; protein phosphorylation [GO:0006468]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10426994}; Single-pass type I membrane protein {ECO:0000269|PubMed:10426994}.
Q9UBK8	reviewed	MTRR_HUMAN	Methionine synthase reductase (MSR) (EC 1.16.1.8) (Aquacobalamin reductase) (AqCbl reductase)	MTRR	Homo sapiens (Human)	698	FUNCTION: Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin (PubMed:17892308). Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species (Probable). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme (PubMed:16769880). Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (PubMed:16769880). {ECO:0000250|UniProtKB:Q8C1A3, ECO:0000269|PubMed:16769880, ECO:0000269|PubMed:17892308, ECO:0000269|PubMed:27771510, ECO:0000305|PubMed:19243433}.	MISCELLANEOUS: It is debated whether the reduction of free aquacob(II)alamin occurs spontaneously or is enzyme catalyzed. {ECO:0000305}.	DNA methylation [GO:0006306]; folic acid metabolic process [GO:0046655]; homocysteine catabolic process [GO:0043418]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; negative regulation of cystathionine beta-synthase activity [GO:1904042]; S-adenosylmethionine cycle [GO:0033353]	cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]	[methionine synthase] reductase activity [GO:0030586]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADPH binding [GO:0070402]; NADPH-hemoprotein reductase activity [GO:0003958]; oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor [GO:0016723]	cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; [methionine synthase] reductase activity [GO:0030586]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADPH binding [GO:0070402]; NADPH-hemoprotein reductase activity [GO:0003958]; oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor [GO:0016723]; DNA methylation [GO:0006306]; folic acid metabolic process [GO:0046655]; homocysteine catabolic process [GO:0043418]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; negative regulation of cystathionine beta-synthase activity [GO:1904042]; S-adenosylmethionine cycle [GO:0033353]	SUBCELLULAR LOCATION: [Isoform B]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform A]: Cytoplasm {ECO:0000269|PubMed:18221906}.
Q9UBK9	reviewed	UXT_HUMAN	Protein UXT (Androgen receptor trapped clone 27 protein) (ART-27) (Ubiquitously expressed transcript protein)	UXT HSPC024	Homo sapiens (Human)	157	FUNCTION: Involved in gene transcription regulation (PubMed:28106301, PubMed:21730289). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed:28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed:17620405, PubMed:21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). {ECO:0000269|PubMed:11827465, ECO:0000269|PubMed:11854421, ECO:0000269|PubMed:16221885, ECO:0000269|PubMed:17554592, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:17635584, ECO:0000269|PubMed:21307340, ECO:0000269|PubMed:21730289, ECO:0000269|PubMed:28106301}.; FUNCTION: [Isoform 1]: Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP. {ECO:0000269|PubMed:21307340}.		apoptotic process [GO:0006915]; centrosome cycle [GO:0007098]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; spindle pole [GO:0000922]	beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; microtubule binding [GO:0008017]; transcription corepressor activity [GO:0003714]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; spindle pole [GO:0000922]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; microtubule binding [GO:0008017]; transcription corepressor activity [GO:0003714]; apoptotic process [GO:0006915]; centrosome cycle [GO:0007098]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:21307340}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:33010352}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21307340, ECO:0000305|PubMed:28106301}. Nucleus {ECO:0000269|PubMed:11854421, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:21307340, ECO:0000305|PubMed:28106301}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16221885}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16221885}. Note=Predominantly localizes to the nucleus (PubMed:16221885). Localizes to spindle pole during mitosis (PubMed:16221885). {ECO:0000269|PubMed:16221885, ECO:0000269|PubMed:21307340}.
Q9UBL3	reviewed	ASH2L_HUMAN	Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)	ASH2L ASH2L1	Homo sapiens (Human)	628	FUNCTION: Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.		DNA damage response [GO:0006974]; hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to estrogen [GO:0043627]; transcription initiation-coupled chromatin remodeling [GO:0045815]	euchromatin [GO:0000791]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]	beta-catenin binding [GO:0008013]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]	euchromatin [GO:0000791]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]; beta-catenin binding [GO:0008013]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; DNA damage response [GO:0006974]; hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to estrogen [GO:0043627]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:17355966}.
Q9UBL6	reviewed	CPNE7_HUMAN	Copine-7 (Copine VII)	CPNE7	Homo sapiens (Human)	633	FUNCTION: Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. {ECO:0000250|UniProtKB:Q99829}.		cellular response to calcium ion [GO:0071277]; lipid metabolic process [GO:0006629]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]; cellular response to calcium ion [GO:0071277]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21087455}. Nucleus {ECO:0000269|PubMed:21087455}. Cell membrane {ECO:0000269|PubMed:21087455}. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455). {ECO:0000269|PubMed:21087455}.
Q9UBL9	reviewed	P2RX2_HUMAN	P2X purinoceptor 2 (P2X2) (ATP receptor) (Purinergic receptor)	P2RX2 P2X2	Homo sapiens (Human)	471	FUNCTION: Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. {ECO:0000269|PubMed:23345450}.		behavioral response to pain [GO:0048266]; calcium ion transmembrane transport [GO:0070588]; detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [GO:0003029]; neuromuscular junction development [GO:0007528]; neuromuscular synaptic transmission [GO:0007274]; peristalsis [GO:0030432]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; response to ATP [GO:0033198]; response to carbohydrate [GO:0009743]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; sensory perception of sound [GO:0007605]; sensory perception of taste [GO:0050909]; skeletal muscle fiber development [GO:0048741]; urinary bladder smooth muscle contraction [GO:0014832]	apical plasma membrane [GO:0016324]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity [GO:0015276]; purinergic nucleotide receptor activity [GO:0001614]	apical plasma membrane [GO:0016324]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity [GO:0015276]; purinergic nucleotide receptor activity [GO:0001614]; behavioral response to pain [GO:0048266]; calcium ion transmembrane transport [GO:0070588]; detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [GO:0003029]; neuromuscular junction development [GO:0007528]; neuromuscular synaptic transmission [GO:0007274]; peristalsis [GO:0030432]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; response to ATP [GO:0033198]; response to carbohydrate [GO:0009743]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; sensory perception of sound [GO:0007605]; sensory perception of taste [GO:0050909]; skeletal muscle fiber development [GO:0048741]; urinary bladder smooth muscle contraction [GO:0014832]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23345450}; Multi-pass membrane protein {ECO:0000269|PubMed:23345450}. Note=Localizes to the apical membranes of hair cells in the organ of Corti.
Q9UBM1	reviewed	PEMT_HUMAN	Phosphatidylethanolamine N-methyltransferase (PEAMT) (PEMT) (EC 2.1.1.17) (EC 2.1.1.71) (PEMT2) (Phospholipid methyltransferase) (PLMT)	PEMT PEMPT PNMT	Homo sapiens (Human)	199	FUNCTION: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure (PubMed:12431977, PubMed:15927961). Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step (PubMed:12431977, PubMed:15927961). Responsible for approximately 30% of hepatic PC with the CDP-choline pathway accounting for the other 70% (Probable). {ECO:0000269|PubMed:12431977, ECO:0000269|PubMed:15927961, ECO:0000305|PubMed:12431977}.; FUNCTION: [Isoform 1]: Catalyzes the three sequential steps of the methylation of 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine (PMME) to 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine (PDME) more efficiently than isoform 2 (PubMed:20860552). Induces increase in PC species with longer polyunsaturated chains than isoform 2 (PubMed:20860552). {ECO:0000269|PubMed:20860552}.; FUNCTION: [Isoform 2]: Produces a higher increase in the level of PC species containing long chains with three double bonds than isoform 1. {ECO:0000269|PubMed:20860552}.		blastocyst hatching [GO:0001835]; methylation [GO:0032259]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of cold-induced thermogenesis [GO:0120162]; sphingomyelin biosynthetic process [GO:0006686]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity [GO:0080101]; phosphatidyl-N-methylethanolamine N-methyltransferase activity [GO:0000773]; phosphatidylethanolamine N-methyltransferase activity [GO:0004608]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phosphatidyl-N-dimethylethanolamine N-methyltransferase activity [GO:0080101]; phosphatidyl-N-methylethanolamine N-methyltransferase activity [GO:0000773]; phosphatidylethanolamine N-methyltransferase activity [GO:0004608]; blastocyst hatching [GO:0001835]; methylation [GO:0032259]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of cold-induced thermogenesis [GO:0120162]; sphingomyelin biosynthetic process [GO:0006686]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:15927961}. Note=localized in the endoplasmic reticulum (ER) of the liver and in a lipid metabolism-rich region of the ER known as mitochondria-associated membranes (PubMed:15927961). Adopts a topography within the ER membrane that positions both termini in the cytosol (PubMed:12431977). {ECO:0000269|PubMed:12431977, ECO:0000303|PubMed:15927961}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20860552}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Mitochondrion membrane {ECO:0000255|HAMAP-Rule:MF_03216}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. {ECO:0000269|PubMed:12431977}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20860552}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}.
Q9UBM4	reviewed	OPT_HUMAN	Opticin (Oculoglycan)	OPTC OPT	Homo sapiens (Human)	332	FUNCTION: Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). {ECO:0000250|UniProtKB:P58874, ECO:0000250|UniProtKB:Q920A0}.		articular cartilage development [GO:0061975]; bone development [GO:0060348]; collagen fibril organization [GO:0030199]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	extracellular matrix structural constituent [GO:0005201]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular matrix structural constituent [GO:0005201]; articular cartilage development [GO:0061975]; bone development [GO:0060348]; collagen fibril organization [GO:0030199]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18164633}.
Q9UBM7	reviewed	DHCR7_HUMAN	7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Delta7-sterol reductase) (Sterol Delta(7)-reductase) (Sterol reductase SR-2)	DHCR7 D7SR	Homo sapiens (Human)	475	FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. {ECO:0000269|PubMed:25637936, ECO:0000269|PubMed:9465114, ECO:0000269|PubMed:9634533}.		brassinosteroid biosynthetic process [GO:0016132]; cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear outer membrane [GO:0005640]	7-dehydrocholesterol reductase activity [GO:0047598]; NADP binding [GO:0050661]; sterol delta7 reductase activity [GO:0009918]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear outer membrane [GO:0005640]; 7-dehydrocholesterol reductase activity [GO:0047598]; NADP binding [GO:0050661]; sterol delta7 reductase activity [GO:0009918]; brassinosteroid biosynthetic process [GO:0016132]; cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9878250}; Multi-pass membrane protein {ECO:0000255}.
Q9UBM8	reviewed	MGT4C_HUMAN	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-acetylglucosaminyltransferase IV homolog) (hGnT-IV-H) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GlcNAc-T IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)	MGAT4C	Homo sapiens (Human)	478	FUNCTION: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity). {ECO:0000250, ECO:0000269|PubMed:10962001}.		protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082]	Golgi membrane [GO:0000139]	acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]; metal ion binding [GO:0046872]	Golgi membrane [GO:0000139]; acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]; metal ion binding [GO:0046872]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9UBN1	reviewed	CCG4_HUMAN	Voltage-dependent calcium channel gamma-4 subunit (Neuronal voltage-gated calcium channel gamma-4 subunit) (Transmembrane AMPAR regulatory protein gamma-4) (TARP gamma-4)	CACNG4	Homo sapiens (Human)	327	FUNCTION: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:21172611). {ECO:0000269|PubMed:21127204, ECO:0000269|PubMed:21172611}.		neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA receptor activity [GO:2000311]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to cocaine [GO:0042220]; transmission of nerve impulse [GO:0019226]	AMPA glutamate receptor complex [GO:0032281]; cell body [GO:0044297]; cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; glutamatergic synapse [GO:0098978]; L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; somatodendritic compartment [GO:0036477]	calcium channel regulator activity [GO:0005246]; channel regulator activity [GO:0016247]; ionotropic glutamate receptor binding [GO:0035255]; voltage-gated calcium channel activity [GO:0005245]	AMPA glutamate receptor complex [GO:0032281]; cell body [GO:0044297]; cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; glutamatergic synapse [GO:0098978]; L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; somatodendritic compartment [GO:0036477]; calcium channel regulator activity [GO:0005246]; channel regulator activity [GO:0016247]; ionotropic glutamate receptor binding [GO:0035255]; voltage-gated calcium channel activity [GO:0005245]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA receptor activity [GO:2000311]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to cocaine [GO:0042220]; transmission of nerve impulse [GO:0019226]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:21127204}; Multi-pass membrane protein {ECO:0000250}.
Q9UBN4	reviewed	TRPC4_HUMAN	Short transient receptor potential channel 4 (TrpC4) (Trp-related protein 4) (hTrp-4) (hTrp4)	TRPC4	Homo sapiens (Human)	977	FUNCTION: Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:16144838, ECO:0000269|PubMed:19996314}.	MISCELLANEOUS: The interaction with spectrin is important in controlling the translocation of TRPC4 channels to the plasma membrane following EGF stimulation.; MISCELLANEOUS: The cell membrane presentation, the calcium entry function and the interaction with junctional proteins (CTNNB1 and CDH5) are controlled by endothelial cell-cell contacts.	calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; gamma-aminobutyric acid secretion [GO:0014051]; oligodendrocyte differentiation [GO:0048709]; regulation of cytosolic calcium ion concentration [GO:0051480]	basolateral plasma membrane [GO:0016323]; calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; caveola [GO:0005901]; cell surface [GO:0009986]; cortical cytoskeleton [GO:0030863]; plasma membrane [GO:0005886]	beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]	basolateral plasma membrane [GO:0016323]; calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; caveola [GO:0005901]; cell surface [GO:0009986]; cortical cytoskeleton [GO:0030863]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]; calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; gamma-aminobutyric acid secretion [GO:0014051]; oligodendrocyte differentiation [GO:0048709]; regulation of cytosolic calcium ion concentration [GO:0051480]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor.
Q9UBN6	reviewed	TR10D_HUMAN	Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264)	TNFRSF10D DCR2 TRAILR4 TRUNDD UNQ251/PRO288	Homo sapiens (Human)	386	FUNCTION: Receptor for the cytotoxic ligand TRAIL (PubMed:9430226). Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis (PubMed:9537512). Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway (PubMed:9382840, PubMed:9430226). {ECO:0000269|PubMed:9382840, ECO:0000269|PubMed:9430226, ECO:0000269|PubMed:9537512}.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; signal transduction [GO:0007165]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	TRAIL binding [GO:0045569]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; TRAIL binding [GO:0045569]; transmembrane signaling receptor activity [GO:0004888]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Q9UBN7	reviewed	HDAC6_HUMAN	Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)	HDAC6 KIAA0901 JM21	Homo sapiens (Human)	1215	FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10220385). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10220385). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10220385). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly; via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). {ECO:0000250|UniProtKB:Q9Z2V5, ECO:0000269|PubMed:10220385, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:26246421, ECO:0000269|PubMed:30538141}.	MISCELLANEOUS: [Isoform 2]: Required for TGF-beta1-activated gene expression associated with epithelial-mesenchymal transition (EMT) in A549 cells. {ECO:0000305}.	aggresome assembly [GO:0070842]; autophagy [GO:0006914]; axonal transport of mitochondrion [GO:0019896]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to misfolded protein [GO:0071218]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to topologically incorrect protein [GO:0035967]; cilium assembly [GO:0060271]; cilium disassembly [GO:0061523]; collateral sprouting [GO:0048668]; dendritic spine morphogenesis [GO:0060997]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of protein-containing complex disassembly [GO:0043242]; negative regulation of proteolysis [GO:0045861]; negative regulation of transcription by RNA polymerase II [GO:0000122]; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:0061734]; peptidyl-lysine deacetylation [GO:0034983]; polyubiquitinated misfolded protein transport [GO:0070845]; positive regulation of cellular response to oxidative stress [GO:1900409]; positive regulation of cholangiocyte proliferation [GO:1904056]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of tubulin deacetylation [GO:0090044]; protein deacetylation [GO:0006476]; protein destabilization [GO:0031648]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein-containing complex disassembly [GO:0032984]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of autophagy [GO:0010506]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of establishment of protein localization [GO:0070201]; regulation of fat cell differentiation [GO:0045598]; regulation of macroautophagy [GO:0016241]; regulation of microtubule-based movement [GO:0060632]; regulation of protein stability [GO:0031647]; response to amphetamine [GO:0001975]; response to corticosterone [GO:0051412]; response to dexamethasone [GO:0071548]; response to growth factor [GO:0070848]; response to immobilization stress [GO:0035902]; response to misfolded protein [GO:0051788]; tubulin deacetylation [GO:0090042]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	aggresome [GO:0016235]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; caveola [GO:0005901]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; histone deacetylase complex [GO:0000118]; inclusion body [GO:0016234]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-catenin binding [GO:0008013]; beta-tubulin binding [GO:0048487]; dynein complex binding [GO:0070840]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; Hsp90 protein binding [GO:0051879]; microtubule binding [GO:0008017]; misfolded protein binding [GO:0051787]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; tau protein binding [GO:0048156]; transcription corepressor binding [GO:0001222]; tubulin deacetylase activity [GO:0042903]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	aggresome [GO:0016235]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; caveola [GO:0005901]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; histone deacetylase complex [GO:0000118]; inclusion body [GO:0016234]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-catenin binding [GO:0008013]; beta-tubulin binding [GO:0048487]; dynein complex binding [GO:0070840]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; Hsp90 protein binding [GO:0051879]; microtubule binding [GO:0008017]; misfolded protein binding [GO:0051787]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; tau protein binding [GO:0048156]; transcription corepressor binding [GO:0001222]; tubulin deacetylase activity [GO:0042903]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; aggresome assembly [GO:0070842]; autophagy [GO:0006914]; axonal transport of mitochondrion [GO:0019896]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to misfolded protein [GO:0071218]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to topologically incorrect protein [GO:0035967]; cilium assembly [GO:0060271]; cilium disassembly [GO:0061523]; collateral sprouting [GO:0048668]; dendritic spine morphogenesis [GO:0060997]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of protein-containing complex disassembly [GO:0043242]; negative regulation of proteolysis [GO:0045861]; negative regulation of transcription by RNA polymerase II [GO:0000122]; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:0061734]; peptidyl-lysine deacetylation [GO:0034983]; polyubiquitinated misfolded protein transport [GO:0070845]; positive regulation of cellular response to oxidative stress [GO:1900409]; positive regulation of cholangiocyte proliferation [GO:1904056]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of tubulin deacetylation [GO:0090044]; protein deacetylation [GO:0006476]; protein destabilization [GO:0031648]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein-containing complex disassembly [GO:0032984]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of autophagy [GO:0010506]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of establishment of protein localization [GO:0070201]; regulation of fat cell differentiation [GO:0045598]; regulation of macroautophagy [GO:0016241]; regulation of microtubule-based movement [GO:0060632]; regulation of protein stability [GO:0031647]; response to amphetamine [GO:0001975]; response to corticosterone [GO:0051412]; response to dexamethasone [GO:0071548]; response to growth factor [GO:0070848]; response to immobilization stress [GO:0035902]; response to misfolded protein [GO:0051788]; tubulin deacetylation [GO:0090042]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:24687993, ECO:0000269|PubMed:26246421}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12024216}. Nucleus {ECO:0000250|UniProtKB:Q9Z2V5}. Perikaryon {ECO:0000250|UniProtKB:Q9Z2V5}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Z2V5}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2V5}. Cell projection, cilium {ECO:0000269|PubMed:17604723}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26246421}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:26246421}. Note=It is mainly cytoplasmic, where it is associated with microtubules. {ECO:0000269|PubMed:12024216}.
Q9UBP0	reviewed	SPAST_HUMAN	Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein)	SPAST ADPSP FSP2 KIAA1083 SPG4	Homo sapiens (Human)	616	FUNCTION: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}.	MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. May also be produced by alternative initiation at Met-87 of isoform 1. Major isoform. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative promoter usage and alternative splicing. May also be produced by alternative initiation at Met-87 of isoform 2. {ECO:0000305}.	anterograde axonal transport [GO:0008089]; axonal transport of mitochondrion [GO:0019896]; axonogenesis [GO:0007409]; cytokinetic process [GO:0032506]; cytoskeleton-dependent cytokinesis [GO:0061640]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; exit from mitosis [GO:0010458]; membrane fission [GO:0090148]; metabolic process [GO:0008152]; microtubule bundle formation [GO:0001578]; microtubule severing [GO:0051013]; mitotic cytokinesis [GO:0000281]; mitotic nuclear membrane reassembly [GO:0007084]; mitotic spindle disassembly [GO:0051228]; nuclear membrane reassembly [GO:0031468]; positive regulation of cytokinesis [GO:0032467]; positive regulation of microtubule depolymerization [GO:0031117]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; microtubule [GO:0005874]; midbody [GO:0030496]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922]	alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; beta-tubulin binding [GO:0048487]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568]; protein-containing complex binding [GO:0044877]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; microtubule [GO:0005874]; midbody [GO:0030496]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; beta-tubulin binding [GO:0048487]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568]; protein-containing complex binding [GO:0044877]; anterograde axonal transport [GO:0008089]; axonal transport of mitochondrion [GO:0019896]; axonogenesis [GO:0007409]; cytokinetic process [GO:0032506]; cytoskeleton-dependent cytokinesis [GO:0061640]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; exit from mitosis [GO:0010458]; membrane fission [GO:0090148]; metabolic process [GO:0008152]; microtubule bundle formation [GO:0001578]; microtubule severing [GO:0051013]; mitotic cytokinesis [GO:0000281]; mitotic nuclear membrane reassembly [GO:0007084]; mitotic spindle disassembly [GO:0051228]; nuclear membrane reassembly [GO:0031468]; positive regulation of cytokinesis [GO:0032467]; positive regulation of microtubule depolymerization [GO:0031117]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Membrane {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:19000169}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000305|PubMed:20200447}. Endoplasmic reticulum {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:16602018}. Midbody {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:18997780, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:25390646}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15269182, ECO:0000269|PubMed:15891913, ECO:0000269|PubMed:25390646}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:18410514, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20200447}. Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15147984, ECO:0000269|PubMed:15269182, ECO:0000269|PubMed:15537668}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15147984, ECO:0000269|PubMed:15269182, ECO:0000269|PubMed:16026783}. Cytoplasm, cytoskeleton, spindle {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15269182}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:16026783, ECO:0000269|PubMed:20200447}. Cell projection, axon {ECO:0000269|PubMed:15269182}. Note=Forms an intramembrane hairpin-like structure in the membrane (PubMed:20200447). Localization to the centrosome is independent of microtubules (PubMed:15891913). Localizes to the midbody of dividing cells, and this requires CHMP1B (PubMed:18997780). Enriched in the distal axons and branches of postmitotic neurons (PubMed:15269182). Mainly nuclear in interphase cells and becomes associated with the centrosomes, spindle microtubules, midzone and finally the midbody during cell division (PubMed:15269182). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15269182, ECO:0000269|PubMed:15891913, ECO:0000269|PubMed:18997780, ECO:0000305|PubMed:20200447}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:23969831}; Peripheral membrane protein {ECO:0000305|PubMed:20200447}. Nucleus membrane {ECO:0000269|PubMed:26040712}. Lipid droplet {ECO:0000269|PubMed:25875445}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20200447}. Endosome {ECO:0000269|PubMed:23897888}. Note=Forms an intramembrane hairpin-like structure in the membrane (PubMed:20200447). Recruited to nuclear membrane by IST1 during late anaphase (PubMed:26040712). Localizes to endoplasmic reticulum tubular network (PubMed:23969831). {ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:26040712, ECO:0000305|PubMed:20200447}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:20200447, ECO:0000269|PubMed:23969831}. Endosome {ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:23897888}. Nucleus membrane {ECO:0000269|PubMed:16026783, ECO:0000269|PubMed:26040712}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25390646}. Note=Constitutes the main endosomal form (PubMed:19000169). Recruited to nuclear membrane by IST1 during late anaphase (PubMed:26040712). {ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:26040712}.
Q9UBP4	reviewed	DKK3_HUMAN	Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (hDkk-3)	DKK3 REIC UNQ258/PRO295	Homo sapiens (Human)	350	FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.		adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of anti-Mullerian hormone signaling pathway [GO:1902613]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; Wnt signaling pathway [GO:0016055]	extracellular space [GO:0005615]	co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019]	extracellular space [GO:0005615]; co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of anti-Mullerian hormone signaling pathway [GO:1902613]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Secreted.
Q9UBP5	reviewed	HEY2_HUMAN	Hairy/enhancer-of-split related with YRPW motif protein 2 (Cardiovascular helix-loop-helix factor 1) (hCHF1) (Class B basic helix-loop-helix protein 32) (bHLHb32) (HES-related repressor protein 2) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HRT-2) (hHRT2) (Protein gridlock homolog)	HEY2 BHLHB32 CHF1 GRL HERP HERP1 HRT2	Homo sapiens (Human)	337	FUNCTION: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000269|PubMed:10692439, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:16293227}.		anterior/posterior axis specification [GO:0009948]; anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; arterial endothelial cell differentiation [GO:0060842]; ascending aorta morphogenesis [GO:0035910]; atrial septum morphogenesis [GO:0060413]; cardiac conduction system development [GO:0003161]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell apoptotic process [GO:0010659]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell fate commitment [GO:0045165]; circulatory system development [GO:0072359]; cochlea development [GO:0090102]; coronary vasculature morphogenesis [GO:0060977]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion to mesenchymal transition involved in heart valve formation [GO:0003199]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; heart trabecula formation [GO:0060347]; labyrinthine layer blood vessel development [GO:0060716]; mesenchymal cell development [GO:0014031]; muscular septum morphogenesis [GO:0003150]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cardiac vascular smooth muscle cell differentiation [GO:2000723]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription by transcription factor localization [GO:0010621]; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [GO:2000820]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of heart rate [GO:0010460]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex assembly [GO:0065004]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of inner ear auditory receptor cell differentiation [GO:0045607]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vasculogenesis [GO:2001212]; smooth muscle cell differentiation [GO:0051145]; tricuspid valve formation [GO:0003195]; tricuspid valve morphogenesis [GO:0003186]; umbilical cord morphogenesis [GO:0036304]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]; ventricular cardiac muscle cell development [GO:0055015]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior axis specification [GO:0009948]; anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; arterial endothelial cell differentiation [GO:0060842]; ascending aorta morphogenesis [GO:0035910]; atrial septum morphogenesis [GO:0060413]; cardiac conduction system development [GO:0003161]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell apoptotic process [GO:0010659]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell fate commitment [GO:0045165]; circulatory system development [GO:0072359]; cochlea development [GO:0090102]; coronary vasculature morphogenesis [GO:0060977]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion to mesenchymal transition involved in heart valve formation [GO:0003199]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; heart trabecula formation [GO:0060347]; labyrinthine layer blood vessel development [GO:0060716]; mesenchymal cell development [GO:0014031]; muscular septum morphogenesis [GO:0003150]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cardiac vascular smooth muscle cell differentiation [GO:2000723]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription by transcription factor localization [GO:0010621]; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [GO:2000820]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of heart rate [GO:0010460]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex assembly [GO:0065004]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of inner ear auditory receptor cell differentiation [GO:0045607]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vasculogenesis [GO:2001212]; smooth muscle cell differentiation [GO:0051145]; tricuspid valve formation [GO:0003195]; tricuspid valve morphogenesis [GO:0003186]; umbilical cord morphogenesis [GO:0036304]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]; ventricular cardiac muscle cell development [GO:0055015]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Q9UBP6	reviewed	TRMB_HUMAN	tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (mRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (miRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase)	METTL1 C12orf1	Homo sapiens (Human)	276	FUNCTION: Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031083, PubMed:31031084, PubMed:36599982, PubMed:36599985, PubMed:37379838, PubMed:37369656). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:12403464, PubMed:34352207, PubMed:34352206, PubMed:36599982, PubMed:36599985, PubMed:37369656). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (PubMed:36599982, PubMed:36599985). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:31031084, PubMed:37379838). Internal N(7)-methylguanine methylation of mRNAs in response to stress promotes their relocalization to stress granules, thereby suppressing their translation (PubMed:31031084, PubMed:37379838). Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083). Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity). {ECO:0000255|HAMAP-Rule:MF_03055, ECO:0000269|PubMed:12403464, ECO:0000269|PubMed:31031083, ECO:0000269|PubMed:31031084, ECO:0000269|PubMed:34352206, ECO:0000269|PubMed:34352207, ECO:0000269|PubMed:36599982, ECO:0000269|PubMed:36599985, ECO:0000269|PubMed:37369656, ECO:0000269|PubMed:37379838}.	MISCELLANEOUS: In the context of cancer, overexpression of the METTL1-WDR4 methyltransferase complex promotes cancer progression by driving oncogenic transformation (PubMed:34352207, PubMed:34352206, PubMed:34371184). Drives oncogenesis by mediating the formation of N(7)-methylguanine at position 46 (m7G46) in some tRNAs, in particular Arg-TCT-4-1 (TRR-TCT4-1), leading to increased translation of mRNAs, including cell cycle regulators that are enriched in the corresponding AGA codon (PubMed:34352207, PubMed:34352206, PubMed:34371184). {ECO:0000269|PubMed:34352206, ECO:0000269|PubMed:34352207, ECO:0000269|PubMed:34371184}.	RNA (guanine-N7)-methylation [GO:0036265]; tRNA (guanine-N7)-methylation [GO:0106004]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA stabilization [GO:0036416]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m7G46) methyltransferase complex [GO:0106143]; tRNA methyltransferase complex [GO:0043527]	tRNA (guanine-N7-)-methyltransferase activity [GO:0008176]; tRNA binding [GO:0000049]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m7G46) methyltransferase complex [GO:0106143]; tRNA methyltransferase complex [GO:0043527]; tRNA (guanine-N7-)-methyltransferase activity [GO:0008176]; tRNA binding [GO:0000049]; RNA (guanine-N7)-methylation [GO:0036265]; tRNA (guanine-N7)-methylation [GO:0106004]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA stabilization [GO:0036416]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15861136, ECO:0000269|PubMed:26751069}.
Q9UBP9	reviewed	GULP1_HUMAN	PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP)	GULP1 CED6 GULP	Homo sapiens (Human)	304	FUNCTION: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. {ECO:0000269|PubMed:10574763, ECO:0000269|PubMed:10574771, ECO:0000269|PubMed:16497666, ECO:0000269|PubMed:17398097}.		apoptotic process [GO:0006915]; lipid transport [GO:0006869]; phagocytosis, engulfment [GO:0006911]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; apoptotic process [GO:0006915]; lipid transport [GO:0006869]; phagocytosis, engulfment [GO:0006911]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16497666}. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes.
Q9UBQ0	reviewed	VPS29_HUMAN	Vacuolar protein sorting-associated protein 29 (hVPS29) (PEP11 homolog) (Vesicle protein sorting 29)	VPS29 DC15 DC7 MDS007	Homo sapiens (Human)	182	FUNCTION: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922, PubMed:21725319, PubMed:23563491). Acts also as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (PubMed:24856514). {ECO:0000269|PubMed:24856514, ECO:0000269|PubMed:28892079, ECO:0000303|PubMed:15247922, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:23563491}.; FUNCTION: (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus. {ECO:0000269|PubMed:25693203}.		endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]	metal ion binding [GO:0046872]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; metal ion binding [GO:0046872]; endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Endosome membrane {ECO:0000250|UniProtKB:Q9QZ88}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9QZ88}. Early endosome {ECO:0000305}. Late endosome {ECO:0000305}.
Q9UBQ5	reviewed	EIF3K_HUMAN	Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (Muscle-specific gene M9 protein) (PLAC-24) (eIF-3 p25) (eIF-3 p28)	EIF3K EIF3S12 ARG134 HSPC029 MSTP001 PTD001	Homo sapiens (Human)	218	FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.		formation of cytoplasmic translation initiation complex [GO:0001732]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; membrane [GO:0016020]; nucleus [GO:0005634]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; membrane [GO:0016020]; nucleus [GO:0005634]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; formation of cytoplasmic translation initiation complex [GO:0001732]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:15327989}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:15327989}.
Q9UBQ6	reviewed	EXTL2_HUMAN	Exostosin-like 2 (EC 2.4.1.223) (Alpha-1,4-N-acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) [Cleaved into: Processed exostosin-like 2]	EXTL2 EXTR2	Homo sapiens (Human)	330	FUNCTION: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. {ECO:0000269|PubMed:10318803}.		heparan sulfate proteoglycan biosynthetic process [GO:0015012]; N-acetylglucosamine metabolic process [GO:0006044]; UDP-N-acetylgalactosamine metabolic process [GO:0019276]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]	alpha-1,4-N-acetylgalactosaminyltransferase activity [GO:0035248]; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888]; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047237]; glycosaminoglycan binding [GO:0005539]; manganese ion binding [GO:0030145]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; alpha-1,4-N-acetylgalactosaminyltransferase activity [GO:0035248]; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888]; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047237]; glycosaminoglycan binding [GO:0005539]; manganese ion binding [GO:0030145]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; N-acetylglucosamine metabolic process [GO:0006044]; UDP-N-acetylgalactosamine metabolic process [GO:0019276]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Processed exostosin-like 2]: Secreted. Note=A soluble form is found in the serum.
Q9UBQ7	reviewed	GRHPR_HUMAN	Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81)	GRHPR GLXR MSTP035	Homo sapiens (Human)	328	FUNCTION: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidizes D-glycerate to hydroxypyruvate. {ECO:0000269|PubMed:10484776, ECO:0000269|PubMed:10524214}.		carboxylic acid metabolic process [GO:0019752]; dicarboxylic acid metabolic process [GO:0043648]; glyoxylate metabolic process [GO:0046487]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxisomal matrix [GO:0005782]	carboxylic acid binding [GO:0031406]; glycerate dehydrogenase activity [GO:0008465]; glyoxylate reductase (NADP+) activity [GO:0030267]; hydroxypyruvate reductase activity [GO:0016618]; NAD binding [GO:0051287]; NADPH binding [GO:0070402]; protein homodimerization activity [GO:0042803]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxisomal matrix [GO:0005782]; carboxylic acid binding [GO:0031406]; glycerate dehydrogenase activity [GO:0008465]; glyoxylate reductase (NADP+) activity [GO:0030267]; hydroxypyruvate reductase activity [GO:0016618]; NAD binding [GO:0051287]; NADPH binding [GO:0070402]; protein homodimerization activity [GO:0042803]; carboxylic acid metabolic process [GO:0019752]; dicarboxylic acid metabolic process [GO:0043648]; glyoxylate metabolic process [GO:0046487]	
Q9UBR1	reviewed	BUP1_HUMAN	Beta-ureidopropionase (EC 3.5.1.6) (BUP-1) (Beta-alanine synthase) (N-carbamoyl-beta-alanine amidohydrolase)	UPB1 BUP1	Homo sapiens (Human)	384	FUNCTION: Catalyzes a late step in pyrimidine degradation (PubMed:22525402, PubMed:24526388). Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide (PubMed:10542323, PubMed:11508704, PubMed:10415095, PubMed:29976570, PubMed:22525402, PubMed:24526388). Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable). {ECO:0000269|PubMed:10415095, ECO:0000269|PubMed:10542323, ECO:0000269|PubMed:11508704, ECO:0000269|PubMed:22525402, ECO:0000269|PubMed:24526388, ECO:0000269|PubMed:29976570, ECO:0000305|PubMed:22525402, ECO:0000305|PubMed:24526388}.		beta-alanine biosynthetic process via 3-ureidopropionate [GO:0033396]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dUMP catabolic process [GO:0046079]; in utero embryonic development [GO:0001701]; liver development [GO:0001889]; protein homooligomerization [GO:0051260]; protein homotetramerization [GO:0051289]; pyrimidine nucleoside catabolic process [GO:0046135]; UMP catabolic process [GO:0046050]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	beta-ureidopropionase activity [GO:0003837]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; beta-ureidopropionase activity [GO:0003837]; protein homodimerization activity [GO:0042803]; beta-alanine biosynthetic process via 3-ureidopropionate [GO:0033396]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dUMP catabolic process [GO:0046079]; in utero embryonic development [GO:0001701]; liver development [GO:0001889]; protein homooligomerization [GO:0051260]; protein homotetramerization [GO:0051289]; pyrimidine nucleoside catabolic process [GO:0046135]; UMP catabolic process [GO:0046050]	SUBCELLULAR LOCATION: Cytoplasm.
Q9UBR2	reviewed	CATZ_HUMAN	Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X)	CTSZ	Homo sapiens (Human)	303	FUNCTION: Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity). {ECO:0000250|UniProtKB:Q9R1T3, ECO:0000269|PubMed:10504234}.		angiotensin maturation [GO:0002003]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; negative regulation of plasminogen activation [GO:0010757]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]	cell cortex [GO:0005938]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]	carboxypeptidase activity [GO:0004180]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]	cell cortex [GO:0005938]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; carboxypeptidase activity [GO:0004180]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; angiotensin maturation [GO:0002003]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; negative regulation of plasminogen activation [GO:0010757]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]	SUBCELLULAR LOCATION: Lysosome.
Q9UBR4	reviewed	LHX3_HUMAN	LIM/homeobox protein Lhx3 (LIM homeobox protein 3)	LHX3	Homo sapiens (Human)	397	FUNCTION: Transcription factor. Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2. Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system (PubMed:21149718). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (By similarity). {ECO:0000250|UniProtKB:P50481, ECO:0000269|PubMed:21149718}.		animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; inner ear development [GO:0048839]; lung development [GO:0030324]; medial motor column neuron differentiation [GO:0021526]; motor neuron axon guidance [GO:0008045]; negative regulation of apoptotic process [GO:0043066]; neuron differentiation [GO:0030182]; placenta development [GO:0001890]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prolactin secreting cell differentiation [GO:0060127]; regulation of transcription by RNA polymerase II [GO:0006357]; somatotropin secreting cell differentiation [GO:0060126]; spinal cord association neuron differentiation [GO:0021527]; spinal cord motor neuron cell fate specification [GO:0021520]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; ventral spinal cord interneuron specification [GO:0021521]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; inner ear development [GO:0048839]; lung development [GO:0030324]; medial motor column neuron differentiation [GO:0021526]; motor neuron axon guidance [GO:0008045]; negative regulation of apoptotic process [GO:0043066]; neuron differentiation [GO:0030182]; placenta development [GO:0001890]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prolactin secreting cell differentiation [GO:0060127]; regulation of transcription by RNA polymerase II [GO:0006357]; somatotropin secreting cell differentiation [GO:0060126]; spinal cord association neuron differentiation [GO:0021527]; spinal cord motor neuron cell fate specification [GO:0021520]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; ventral spinal cord interneuron specification [GO:0021521]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UBR5	reviewed	CKLF_HUMAN	Chemokine-like factor (C32)	CKLF CKLF1 HSPC224 UNQ410/PRO772	Homo sapiens (Human)	152	FUNCTION: May play an important role in inflammation and regeneration of skeletal muscle (PubMed:11415443). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:Q9DAS1, ECO:0000269|PubMed:11415443}.; FUNCTION: [Isoform 1]: Has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:11415443). Binds CCR4 (PubMed:16137713). {ECO:0000269|PubMed:11415443, ECO:0000269|PubMed:16137713}.		lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; neutrophil chemotaxis [GO:0030593]; secretion by cell [GO:0032940]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]	chemokine activity [GO:0008009]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; chemokine activity [GO:0008009]; lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; neutrophil chemotaxis [GO:0030593]; secretion by cell [GO:0032940]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000269|PubMed:11415443, ECO:0000269|PubMed:16137713}.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9UBS0	reviewed	KS6B2_HUMAN	Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta)	RPS6KB2 STK14B	Homo sapiens (Human)	482	FUNCTION: Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). {ECO:0000269|PubMed:29750193}.		phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of translational initiation [GO:0045948]; signal transduction [GO:0007165]; TOR signaling [GO:0031929]; translation [GO:0006412]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; peptide binding [GO:0042277]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosomal protein S6 kinase activity [GO:0004711]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; peptide binding [GO:0042277]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosomal protein S6 kinase activity [GO:0004711]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of translational initiation [GO:0045948]; signal transduction [GO:0007165]; TOR signaling [GO:0031929]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q9UBS3	reviewed	DNJB9_HUMAN	DnaJ homolog subfamily B member 9 (Endoplasmic reticulum DNA J domain-containing protein 4) (ER-resident protein ERdj4) (ERdj4) (Microvascular endothelial differentiation gene 1 protein) (Mdg-1)	DNAJB9 MDG1 UNQ743/PRO1471	Homo sapiens (Human)	223	FUNCTION: Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity). {ECO:0000250|UniProtKB:G3H0N9, ECO:0000250|UniProtKB:Q9QYI6, ECO:0000269|PubMed:18400946}.		B cell differentiation [GO:0030183]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; positive regulation of immunoglobulin production [GO:0002639]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]	Hsp70 protein binding [GO:0030544]; misfolded protein binding [GO:0051787]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; Hsp70 protein binding [GO:0030544]; misfolded protein binding [GO:0051787]; protein-folding chaperone binding [GO:0051087]; B cell differentiation [GO:0030183]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; positive regulation of immunoglobulin production [GO:0002639]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q9QYI6}.
Q9UBS4	reviewed	DJB11_HUMAN	DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (DnaJ protein homolog 9) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (HEDJ) (Human DnaJ protein 9) (hDj-9) (PWP1-interacting protein 4)	DNAJB11 EDJ ERJ3 HDJ9 PSEC0121 UNQ537/PRO1080	Homo sapiens (Human)	358	FUNCTION: As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351). Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676). May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:10827079). It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351). {ECO:0000269|PubMed:10827079, ECO:0000269|PubMed:15525676, ECO:0000269|PubMed:29706351}.		mRNA modification [GO:0016556]; negative regulation of neurogenesis [GO:0050768]; positive regulation of ATP-dependent activity [GO:0032781]; protein folding [GO:0006457]; protein maturation [GO:0051604]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]	misfolded protein binding [GO:0051787]; signaling receptor binding [GO:0005102]; unfolded protein binding [GO:0051082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; misfolded protein binding [GO:0051787]; signaling receptor binding [GO:0005102]; unfolded protein binding [GO:0051082]; mRNA modification [GO:0016556]; negative regulation of neurogenesis [GO:0050768]; positive regulation of ATP-dependent activity [GO:0032781]; protein folding [GO:0006457]; protein maturation [GO:0051604]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:10827079, ECO:0000269|PubMed:15195998, ECO:0000269|PubMed:15525676, ECO:0000269|PubMed:15544163}. Note=Associated with the ER membrane in a C-terminally epitope-tagged construct.
Q9UBS5	reviewed	GABR1_HUMAN	Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1)	GABBR1 GPRC3A	Homo sapiens (Human)	961	FUNCTION: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10906333, PubMed:10773016, PubMed:10075644, PubMed:9872744, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9844003, PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:9844003, PubMed:9872316, PubMed:24305054). {ECO:0000250|UniProtKB:Q9Z0U4, ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:10773016, ECO:0000269|PubMed:10906333, ECO:0000269|PubMed:15617512, ECO:0000269|PubMed:18165688, ECO:0000269|PubMed:22660477, ECO:0000269|PubMed:24305054, ECO:0000269|PubMed:9844003, ECO:0000269|PubMed:9872316, ECO:0000269|PubMed:9872744, ECO:0000305}.; FUNCTION: Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.	MISCELLANEOUS: [Isoform 1E]: Major isoform in almost all peripheral tissues, although containing a premature stop codon in the mRNA and thus being a potential target for nonsense-mediated mRNA decay. May act as an antagonist of GABA-B receptors, being able to disrupt the normal association between isoform 1A and GABBR2. {ECO:0000269|PubMed:10906333}.	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; negative regulation of synaptic transmission [GO:0050805]; neuron-glial cell signaling [GO:0150099]; osteoblast differentiation [GO:0001649]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of growth hormone secretion [GO:0060124]; response to ethanol [GO:0045471]; response to nicotine [GO:0035094]; synaptic transmission, GABAergic [GO:0051932]	axolemma [GO:0030673]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]	extracellular matrix protein binding [GO:1990430]; G protein-coupled GABA receptor activity [GO:0004965]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [GO:0099579]; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential [GO:0150047]; protein heterodimerization activity [GO:0046982]	axolemma [GO:0030673]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; extracellular matrix protein binding [GO:1990430]; G protein-coupled GABA receptor activity [GO:0004965]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [GO:0099579]; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential [GO:0150047]; protein heterodimerization activity [GO:0046982]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; negative regulation of synaptic transmission [GO:0050805]; neuron-glial cell signaling [GO:0150099]; osteoblast differentiation [GO:0001649]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of growth hormone secretion [GO:0060124]; response to ethanol [GO:0045471]; response to nicotine [GO:0035094]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15617512}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9Z0U4}; Multi-pass membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Z0U4}. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane (PubMed:15617512). {ECO:0000250|UniProtKB:Q9Z0U4, ECO:0000269|PubMed:15617512}.; SUBCELLULAR LOCATION: [Isoform 1E]: Secreted {ECO:0000305}.
Q9UBS8	reviewed	RNF14_HUMAN	E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14)	RNF14 ARA54 HRIHFB2038	Homo sapiens (Human)	474	FUNCTION: E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates ubiquitination of EEF1A1/eEF1A, leading to its degradation (PubMed:36638793). In addition to EEF1A1/eEF1A, RNF14 catalyzes ubiquitination of other translation factors on stalled ribosomes: mediates ubiquitination and degradation of ETF1/eRF1 and ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (PubMed:23449499). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (PubMed:19345326). {ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:23449499, ECO:0000269|PubMed:36638793}.		androgen receptor signaling pathway [GO:0030521]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rescue of stalled ribosome [GO:0072344]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	nuclear androgen receptor binding [GO:0050681]; transcription coactivator activity [GO:0003713]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein transferase activity [GO:0019787]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; nuclear androgen receptor binding [GO:0050681]; transcription coactivator activity [GO:0003713]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein transferase activity [GO:0019787]; zinc ion binding [GO:0008270]; androgen receptor signaling pathway [GO:0030521]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rescue of stalled ribosome [GO:0072344]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9853615}. Nucleus {ECO:0000269|PubMed:9853615}.
Q9UBS9	reviewed	SUCO_HUMAN	SUN domain-containing ossification factor (Membrane protein CH1) (Protein osteopotentia homolog) (SUN-like protein 1)	SUCO C1orf9 CH1 OPT SLP1	Homo sapiens (Human)	1254	FUNCTION: Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity). {ECO:0000250}.		ossification [GO:0001503]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of bone remodeling [GO:0046850]	cytoplasm [GO:0005737]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791]; rough endoplasmic reticulum membrane [GO:0030867]		cytoplasm [GO:0005737]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791]; rough endoplasmic reticulum membrane [GO:0030867]; ossification [GO:0001503]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of bone remodeling [GO:0046850]	SUBCELLULAR LOCATION: Rough endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9UBT2	reviewed	SAE2_HUMAN	SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)	UBA2 SAE2 UBLE1B HRIHFB2115	Homo sapiens (Human)	640	FUNCTION: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}.		positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; SUMO activating enzyme complex [GO:0031510]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; small protein activating enzyme binding [GO:0044388]; SUMO activating enzyme activity [GO:0019948]; SUMO binding [GO:0032183]; transferase activity [GO:0016740]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; SUMO activating enzyme complex [GO:0031510]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; small protein activating enzyme binding [GO:0044388]; SUMO activating enzyme activity [GO:0019948]; SUMO binding [GO:0032183]; transferase activity [GO:0016740]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
Q9UBT3	reviewed	DKK4_HUMAN	Dickkopf-related protein 4 (Dickkopf-4) (Dkk-4) (hDkk-4) [Cleaved into: Dickkopf-related protein 4 short form]	DKK4	Homo sapiens (Human)	224	FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of hair follicle placode formation [GO:0061170]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055]	extracellular space [GO:0005615]	co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019]	extracellular space [GO:0005615]; co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of hair follicle placode formation [GO:0061170]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Secreted.
Q9UBT6	reviewed	POLK_HUMAN	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP)	POLK DINB1	Homo sapiens (Human)	870	FUNCTION: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. {ECO:0000269|PubMed:10620008, ECO:0000269|PubMed:11024016, ECO:0000269|PubMed:12145297, ECO:0000269|PubMed:12444249, ECO:0000269|PubMed:12952891, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15533436, ECO:0000269|PubMed:28297716}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; error-prone translesion synthesis [GO:0042276]; nucleotide-excision repair, DNA gap filling [GO:0006297]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; error-prone translesion synthesis [GO:0042276]; nucleotide-excision repair, DNA gap filling [GO:0006297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12414988, ECO:0000269|PubMed:28297716}. Note=Detected throughout the nucleus and at replication foci (PubMed:12414988). Recruited to DNA damage sites in response to ultraviolet irradiation: N6-methyladenosine (m6A)-containing mRNAs accumulate in the vicinity of DNA damage sites and their presence is required to recruit POLK (PubMed:28297716). {ECO:0000269|PubMed:12414988, ECO:0000269|PubMed:28297716}.
Q9UBT7	reviewed	CTNL1_HUMAN	Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1)	CTNNAL1	Homo sapiens (Human)	734	FUNCTION: May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).		cell adhesion [GO:0007155]; Rho protein signal transduction [GO:0007266]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; cell adhesion [GO:0007155]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12270917}. Cell membrane {ECO:0000269|PubMed:12270917}; Peripheral membrane protein {ECO:0000269|PubMed:12270917}.
Q9UBU3	reviewed	GHRL_HUMAN	Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Protein M46) [Cleaved into: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin]	GHRL MTLRP UNQ524/PRO1066	Homo sapiens (Human)	117	FUNCTION: [Ghrelin-27]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. {ECO:0000269|PubMed:10604470}.; FUNCTION: [Ghrelin-28]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. {ECO:0000269|PubMed:10604470}.; FUNCTION: [Obestatin]: May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). {ECO:0000250}.		actin polymerization or depolymerization [GO:0008154]; adult feeding behavior [GO:0008343]; cartilage development [GO:0051216]; cortisol secretion [GO:0043400]; decidualization [GO:0046697]; dendrite development [GO:0016358]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled receptor signaling pathway [GO:0007186]; gastric acid secretion [GO:0001696]; glucose metabolic process [GO:0006006]; growth hormone secretion [GO:0030252]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin secretion [GO:0046676]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of locomotion [GO:0040013]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of appetite [GO:0032100]; positive regulation of bone development [GO:1903012]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of corticotropin secretion [GO:0051461]; positive regulation of cortisol secretion [GO:0051464]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of eating behavior [GO:1904000]; positive regulation of gastric mucosal blood circulation [GO:1904346]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of growth rate [GO:0040010]; positive regulation of insulin secretion [GO:0032024]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of small intestinal transit [GO:0120058]; positive regulation of small intestine smooth muscle contraction [GO:1904349]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of synapse assembly [GO:0051965]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of cell population proliferation [GO:0042127]; regulation of gastric motility [GO:1905333]; regulation of postsynapse organization [GO:0099175]; regulation of response to food [GO:0032095]; regulation of transmission of nerve impulse [GO:0051969]; response to electrical stimulus [GO:0051602]; response to estrogen [GO:0043627]; response to hormone [GO:0009725]; synapse assembly [GO:0007416]	axon [GO:0030424]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule lumen [GO:0034774]	G protein-coupled receptor binding [GO:0001664]; ghrelin receptor binding [GO:0031768]; growth hormone-releasing hormone activity [GO:0016608]; protein tyrosine kinase activator activity [GO:0030296]	axon [GO:0030424]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule lumen [GO:0034774]; G protein-coupled receptor binding [GO:0001664]; ghrelin receptor binding [GO:0031768]; growth hormone-releasing hormone activity [GO:0016608]; protein tyrosine kinase activator activity [GO:0030296]; actin polymerization or depolymerization [GO:0008154]; adult feeding behavior [GO:0008343]; cartilage development [GO:0051216]; cortisol secretion [GO:0043400]; decidualization [GO:0046697]; dendrite development [GO:0016358]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled receptor signaling pathway [GO:0007186]; gastric acid secretion [GO:0001696]; glucose metabolic process [GO:0006006]; growth hormone secretion [GO:0030252]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin secretion [GO:0046676]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of locomotion [GO:0040013]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of appetite [GO:0032100]; positive regulation of bone development [GO:1903012]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of corticotropin secretion [GO:0051461]; positive regulation of cortisol secretion [GO:0051464]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of eating behavior [GO:1904000]; positive regulation of gastric mucosal blood circulation [GO:1904346]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of growth rate [GO:0040010]; positive regulation of insulin secretion [GO:0032024]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of small intestinal transit [GO:0120058]; positive regulation of small intestine smooth muscle contraction [GO:1904349]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of synapse assembly [GO:0051965]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of cell population proliferation [GO:0042127]; regulation of gastric motility [GO:1905333]; regulation of postsynapse organization [GO:0099175]; regulation of response to food [GO:0032095]; regulation of transmission of nerve impulse [GO:0051969]; response to electrical stimulus [GO:0051602]; response to estrogen [GO:0043627]; response to hormone [GO:0009725]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Secreted.
Q9UBU7	reviewed	DBF4A_HUMAN	Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1)	DBF4 ASK DBF4A ZDBF1	Homo sapiens (Human)	674	FUNCTION: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}.		DNA replication [GO:0006260]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; regulation of cell cycle phase transition [GO:1901987]	Dbf4-dependent protein kinase complex [GO:0031431]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	enzyme activator activity [GO:0008047]; nucleic acid binding [GO:0003676]; protein serine/threonine kinase activator activity [GO:0043539]; zinc ion binding [GO:0008270]	Dbf4-dependent protein kinase complex [GO:0031431]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; enzyme activator activity [GO:0008047]; nucleic acid binding [GO:0003676]; protein serine/threonine kinase activator activity [GO:0043539]; zinc ion binding [GO:0008270]; DNA replication [GO:0006260]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; regulation of cell cycle phase transition [GO:1901987]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10373557}.
Q9UBU8	reviewed	MO4L1_HUMAN	Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (Protein MSL3-1) (Transcription factor-like protein MRG15)	MORF4L1 MRG15 FWP006 HSPC008 HSPC061 PP368	Homo sapiens (Human)	362	FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:20332121}.		chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; fibroblast proliferation [GO:0048144]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]	NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; Sin3 complex [GO:0016580]	chromatin binding [GO:0003682]	NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; Sin3 complex [GO:0016580]; chromatin binding [GO:0003682]; chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; fibroblast proliferation [GO:0048144]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]	SUBCELLULAR LOCATION: Nucleus.
Q9UBU9	reviewed	NXF1_HUMAN	Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP)	NXF1 TAP	Homo sapiens (Human)	619	FUNCTION: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}.		mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear inclusion body [GO:0042405]; nuclear pore [GO:0005643]; nuclear RNA export factor complex [GO:0042272]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear inclusion body [GO:0042405]; nuclear pore [GO:0005643]; nuclear RNA export factor complex [GO:0042272]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:25662211}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332}. Nucleus speckle {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:23591820}. Nucleus envelope {ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:23591820}. Cytoplasm {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:19864460}. Cytoplasm, Stress granule {ECO:0000269|PubMed:18596238}. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles (PubMed:23826332). Nucleus; nuclear rim (PubMed:25662211). {ECO:0000269|PubMed:23826332, ECO:0000269|PubMed:25662211}.
Q9UBV2	reviewed	SE1L1_HUMAN	Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L)	SEL1L TSA305 UNQ128/PRO1063	Homo sapiens (Human)	794	FUNCTION: Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. {ECO:0000250|UniProtKB:Q9Z2G6, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:29997207}.		ERAD pathway [GO:0036503]; Notch signaling pathway [GO:0007219]; protein secretion [GO:0009306]; protein stabilization [GO:0050821]; retrograde protein transport, ER to cytosol [GO:0030970]; triglyceride metabolic process [GO:0006641]; ubiquitin-dependent ERAD pathway [GO:0030433]	Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase complex [GO:0000836]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]		Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase complex [GO:0000836]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; ERAD pathway [GO:0036503]; Notch signaling pathway [GO:0007219]; protein secretion [GO:0009306]; protein stabilization [GO:0050821]; retrograde protein transport, ER to cytosol [GO:0030970]; triglyceride metabolic process [GO:0006641]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16186509}; Single-pass type I membrane protein {ECO:0000269|PubMed:16186509}.
Q9UBV4	reviewed	WNT16_HUMAN	Protein Wnt-16	WNT16	Homo sapiens (Human)	365	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}.		bone remodeling [GO:0046849]; canonical Wnt signaling pathway [GO:0060070]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell fate commitment [GO:0045165]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of apoptotic signaling pathway [GO:2001234]; neuron differentiation [GO:0030182]; optic cup formation involved in camera-type eye development [GO:0003408]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; replicative senescence [GO:0090399]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; bone remodeling [GO:0046849]; canonical Wnt signaling pathway [GO:0060070]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell fate commitment [GO:0045165]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of apoptotic signaling pathway [GO:2001234]; neuron differentiation [GO:0030182]; optic cup formation involved in camera-type eye development [GO:0003408]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; replicative senescence [GO:0090399]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q9UBV7	reviewed	B4GT7_HUMAN	Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (EC 2.4.1.-) (Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-xylose beta-1,4-galactosyltransferase) (XGPT) (XGalT-1) (Xylosylprotein 4-beta-galactosyltransferase) (EC 2.4.1.133) (Xylosylprotein beta-1,4-galactosyltransferase)	B4GALT7 XGALT1 UNQ748/PRO1478	Homo sapiens (Human)	327	FUNCTION: Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts. {ECO:0000269|PubMed:24052259}.		carbohydrate metabolic process [GO:0005975]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; glycosylation [GO:0070085]; negative regulation of fibroblast proliferation [GO:0048147]; protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487]; proteoglycan biosynthetic process [GO:0030166]; proteoglycan metabolic process [GO:0006029]; supramolecular fiber organization [GO:0097435]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; galactosyltransferase activity [GO:0008378]; manganese ion binding [GO:0030145]; xylosylprotein 4-beta-galactosyltransferase activity [GO:0046525]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; galactosyltransferase activity [GO:0008378]; manganese ion binding [GO:0030145]; xylosylprotein 4-beta-galactosyltransferase activity [GO:0046525]; carbohydrate metabolic process [GO:0005975]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; glycosylation [GO:0070085]; negative regulation of fibroblast proliferation [GO:0048147]; protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487]; proteoglycan biosynthetic process [GO:0030166]; proteoglycan metabolic process [GO:0006029]; supramolecular fiber organization [GO:0097435]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Cis cisternae of Golgi stack.
Q9UBV8	reviewed	PEF1_HUMAN	Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1)	PEF1 ABP32 UNQ1845/PRO3573	Homo sapiens (Human)	284	FUNCTION: Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium (PubMed:27716508). Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (PubMed:11278427). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity). {ECO:0000250|UniProtKB:Q641Z8, ECO:0000269|PubMed:11278427, ECO:0000269|PubMed:27716508}.		COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592]	COPII vesicle coat [GO:0030127]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	COPII vesicle coat [GO:0030127]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11278427}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q641Z8}. Membrane {ECO:0000269|PubMed:11278427}; Peripheral membrane protein {ECO:0000269|PubMed:11278427}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:27716508}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated in the presence of Ca(2+) (PubMed:11278427). Localizes to endoplasmic reticulum exit site (ERES) (By similarity). {ECO:0000250|UniProtKB:Q641Z8, ECO:0000269|PubMed:11278427}.
Q9UBW5	reviewed	BIN2_HUMAN	Bridging integrator 2 (Breast cancer-associated protein 1)	BIN2 BRAP1	Homo sapiens (Human)	565	FUNCTION: Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.		cell chemotaxis [GO:0060326]; phagocytosis, engulfment [GO:0006911]; plasma membrane tubulation [GO:0097320]; podosome assembly [GO:0071800]	anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cell projection [GO:0042995]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; podosome [GO:0002102]; secretory granule lumen [GO:0034774]	phospholipid binding [GO:0005543]	anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cell projection [GO:0042995]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; podosome [GO:0002102]; secretory granule lumen [GO:0034774]; phospholipid binding [GO:0005543]; cell chemotaxis [GO:0060326]; phagocytosis, engulfment [GO:0006911]; plasma membrane tubulation [GO:0097320]; podosome assembly [GO:0071800]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23285027}. Cell projection, podosome membrane {ECO:0000269|PubMed:23285027}; Peripheral membrane protein {ECO:0000269|PubMed:23285027}; Cytoplasmic side {ECO:0000269|PubMed:23285027}. Cytoplasm, cell cortex {ECO:0000269|PubMed:23285027}. Cell projection, phagocytic cup {ECO:0000269|PubMed:23285027}. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure. {ECO:0000269|PubMed:23285027}.
Q9UBW7	reviewed	ZMYM2_HUMAN	Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198)	ZMYM2 FIM RAMP ZNF198	Homo sapiens (Human)	1377	FUNCTION: Involved in the negative regulation of transcription. {ECO:0000269|PubMed:32891193}.		negative regulation of DNA-templated transcription [GO:0045892]	cytosol [GO:0005829]; nucleus [GO:0005634]; PML body [GO:0016605]	ubiquitin conjugating enzyme binding [GO:0031624]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleus [GO:0005634]; PML body [GO:0016605]; ubiquitin conjugating enzyme binding [GO:0031624]; zinc ion binding [GO:0008270]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32891193}.
Q9UBW8	reviewed	CSN7A_HUMAN	COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a)	COPS7A CSN7A DERP10	Homo sapiens (Human)	275	FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.		COP9 signalosome assembly [GO:0010387]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; COP9 signalosome assembly [GO:0010387]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Q9UBX0	reviewed	HESX1_HUMAN	Homeobox expressed in ES cells 1 (Homeobox protein ANF) (hAnf)	HESX1 HANF	Homo sapiens (Human)	185	FUNCTION: Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation. {ECO:0000250|UniProtKB:Q61658, ECO:0000269|PubMed:26781211}.		brain development [GO:0007420]; camera-type eye development [GO:0043010]; canonical Wnt signaling pathway [GO:0060070]; cellular response to cadmium ion [GO:0071276]; ERK1 and ERK2 cascade [GO:0070371]; forebrain morphogenesis [GO:0048853]; gene expression [GO:0010467]; gonad development [GO:0008406]; leukemia inhibitory factor signaling pathway [GO:0048861]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nose development [GO:0043584]; otic vesicle formation [GO:0030916]; pituitary gland development [GO:0021983]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]; thyroid gland development [GO:0030878]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; canonical Wnt signaling pathway [GO:0060070]; cellular response to cadmium ion [GO:0071276]; ERK1 and ERK2 cascade [GO:0070371]; forebrain morphogenesis [GO:0048853]; gene expression [GO:0010467]; gonad development [GO:0008406]; leukemia inhibitory factor signaling pathway [GO:0048861]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nose development [GO:0043584]; otic vesicle formation [GO:0030916]; pituitary gland development [GO:0021983]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]; thyroid gland development [GO:0030878]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26781211}.
Q9UBX1	reviewed	CATF_HUMAN	Cathepsin F (CATSF) (EC 3.4.22.41)	CTSF	Homo sapiens (Human)	484	FUNCTION: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.		antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	cysteine-type endopeptidase activity [GO:0004197]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; cysteine-type endopeptidase activity [GO:0004197]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]	SUBCELLULAR LOCATION: Lysosome.
Q9UBX2	reviewed	DUX4_HUMAN	Double homeobox protein 4 (Double homeobox protein 10)	DUX4 DUX10	Homo sapiens (Human)	424	FUNCTION: [Isoform 1]: Transcription factor that is selectively and transiently expressed in cleavage-stage embryos (PubMed:28459457). Binds to double-stranded DNA elements with the consensus sequence 5'-TAATCTAATCA-3' (PubMed:28459457, PubMed:28459454, PubMed:29572508, PubMed:30540931, PubMed:30315230). Binds to chromatin containing histone H3 acetylated at 'Lys-27' (H3K27ac) and promotes deacetylation of H3K27ac. In parallel, binds to chromatin that lacks histone H3 acetylation at 'Lys-27' (H3K27ac) and recruits EP300 and CREBBP to promote acetylation of histone H3 at 'Lys-27' at new sites (PubMed:26951377). Involved in transcriptional regulation of numerous genes, primarily as transcriptional activator, but mediates also repression of a set of target genes (PubMed:17984056, PubMed:27378237, PubMed:26951377, PubMed:28459457, PubMed:28459454, PubMed:29618456, PubMed:30540931, PubMed:29572508). Promotes expression of ZSCAN4 and KDM4E, two proteins with essential roles during early embryogenesis (PubMed:27378237, PubMed:26951377, PubMed:28459457, PubMed:29618456). Heterologous expression in cultured embryonic stem cells mediates also transcription of HERVL retrotransposons and transcripts derived from ACRO1 and HSATII satellite repeats (PubMed:28459457). May activate expression of PITX1 (PubMed:17984056). May regulate microRNA (miRNA) expression (PubMed:24145033). Inappropriate expression can inhibit myogenesis and promote apoptosis (PubMed:26951377, PubMed:28935672, PubMed:29618456). {ECO:0000269|PubMed:17984056, ECO:0000269|PubMed:24145033, ECO:0000269|PubMed:26951377, ECO:0000269|PubMed:27378237, ECO:0000269|PubMed:28459454, ECO:0000269|PubMed:28459457, ECO:0000269|PubMed:28935672, ECO:0000269|PubMed:29572508, ECO:0000269|PubMed:29618456, ECO:0000269|PubMed:30315230, ECO:0000269|PubMed:30540931}.; FUNCTION: [Isoform 2]: Probably inactive as a transcriptional activator, due to the absence of the C-terminal region that is important for transcriptional activation. Can inhibit transcriptional activation mediated by isoform 1. Heterologous expression of isoform 2 has no deleterious effect on cell survival. {ECO:0000269|PubMed:29618456}.	MISCELLANEOUS: DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found on the short arms of all acrocentric chromosomes as well as on several other chromosomes. {ECO:0000269|PubMed:10433963, ECO:0000269|PubMed:17984056, ECO:0000269|PubMed:19320656, ECO:0000269|PubMed:21060811}.	apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G0 to G1 transition [GO:0070317]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G0 to G1 transition [GO:0070317]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15709750, ECO:0000269|PubMed:17984056, ECO:0000269|PubMed:21060811, ECO:0000269|PubMed:26951377, ECO:0000269|PubMed:27378237, ECO:0000269|PubMed:28459457, ECO:0000269|PubMed:29618456}. Note=Actively transported through the nuclear pore complex (NPC). {ECO:0000305|PubMed:15709750}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:29618456, ECO:0000305|PubMed:15709750}.
Q9UBX3	reviewed	DIC_HUMAN	Mitochondrial dicarboxylate carrier (DIC) (Solute carrier family 25 member 10)	SLC25A10 DIC	Homo sapiens (Human)	287	FUNCTION: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane (PubMed:29211846). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity). {ECO:0000250|UniProtKB:Q9QZD8, ECO:0000269|PubMed:29211846}.		dicarboxylic acid transport [GO:0006835]; gluconeogenesis [GO:0006094]; lipid transport [GO:0006869]; malate transmembrane transport [GO:0071423]; mitochondrial transport [GO:0006839]; monoatomic ion transport [GO:0006811]; oxaloacetate transport [GO:0015729]; phosphate ion transmembrane transport [GO:0035435]; succinate transmembrane transport [GO:0071422]; sulfate transport [GO:0008272]; sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]; thiosulfate transport [GO:0015709]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	antiporter activity [GO:0015297]; dicarboxylic acid transmembrane transporter activity [GO:0005310]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; phosphate ion transmembrane transporter activity [GO:0015114]; succinate transmembrane transporter activity [GO:0015141]; sulfate transmembrane transporter activity [GO:0015116]; thiosulfate transmembrane transporter activity [GO:0015117]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; antiporter activity [GO:0015297]; dicarboxylic acid transmembrane transporter activity [GO:0005310]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; phosphate ion transmembrane transporter activity [GO:0015114]; succinate transmembrane transporter activity [GO:0015141]; sulfate transmembrane transporter activity [GO:0015116]; thiosulfate transmembrane transporter activity [GO:0015117]; dicarboxylic acid transport [GO:0006835]; gluconeogenesis [GO:0006094]; lipid transport [GO:0006869]; malate transmembrane transport [GO:0071423]; mitochondrial transport [GO:0006839]; monoatomic ion transport [GO:0006811]; oxaloacetate transport [GO:0015729]; phosphate ion transmembrane transport [GO:0035435]; succinate transmembrane transport [GO:0071422]; sulfate transport [GO:0008272]; sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]; thiosulfate transport [GO:0015709]	SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
Q9UBX5	reviewed	FBLN5_HUMAN	Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50)	FBLN5 DANCE UNQ184/PRO210	Homo sapiens (Human)	448	FUNCTION: Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108). {ECO:0000250|UniProtKB:Q9WVH9, ECO:0000269|PubMed:10428823, ECO:0000269|PubMed:17255108, ECO:0000269|PubMed:18185537}.		cell-matrix adhesion [GO:0007160]; elastic fiber assembly [GO:0048251]; protein localization to cell surface [GO:0034394]; regulation of removal of superoxide radicals [GO:2000121]; secretion [GO:0046903]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; protein homodimerization activity [GO:0042803]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; protein homodimerization activity [GO:0042803]; cell-matrix adhesion [GO:0007160]; elastic fiber assembly [GO:0048251]; protein localization to cell surface [GO:0034394]; regulation of removal of superoxide radicals [GO:2000121]; secretion [GO:0046903]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16652333, ECO:0000269|PubMed:17035250, ECO:0000269|PubMed:20599547}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17035250}. Note=co-localizes with ELN in elastic fibers. {ECO:0000269|PubMed:17035250}.
Q9UBX7	reviewed	KLK11_HUMAN	Kallikrein-11 (hK11) (EC 3.4.21.-) (Hippostasin) (Serine protease 20) (Trypsin-like protease) [Cleaved into: Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2]	KLK11 PRSS20 TLSP UNQ649/PRO1279	Homo sapiens (Human)	282	FUNCTION: Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. {ECO:0000269|PubMed:10872828, ECO:0000269|PubMed:16467084}.	MISCELLANEOUS: [Isoform 3]: Localized in the prostate secretory epithelium. {ECO:0000305}.	proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; secretory granule [GO:0030141]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: [Isoform 1]: Secreted.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus.
Q9UBX8	reviewed	B4GT6_HUMAN	Beta-1,4-galactosyltransferase 6 (Beta-1,4-GalTase 6) (Beta4Gal-T6) (b4Gal-T6) (EC 2.4.1.-) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6) (UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6)	B4GALT6	Homo sapiens (Human)	382	FUNCTION: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:3099851, PubMed:1551920, PubMed:24498430). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). {ECO:0000250|UniProtKB:Q9WVK5, ECO:0000269|PubMed:1551920, ECO:0000269|PubMed:24498430, ECO:0000269|PubMed:3099851}.		carbohydrate metabolic process [GO:0005975]; central nervous system myelination [GO:0022010]; central nervous system neuron axonogenesis [GO:0021955]; ganglioside biosynthetic process via lactosylceramide [GO:0010706]; glycosphingolipid biosynthetic process [GO:0006688]; glycosylation [GO:0070085]; lactosylceramide biosynthetic process [GO:0001572]; neuron maturation [GO:0042551]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489]; carbohydrate metabolic process [GO:0005975]; central nervous system myelination [GO:0022010]; central nervous system neuron axonogenesis [GO:0021955]; ganglioside biosynthetic process via lactosylceramide [GO:0010706]; glycosphingolipid biosynthetic process [GO:0006688]; glycosylation [GO:0070085]; lactosylceramide biosynthetic process [GO:0001572]; neuron maturation [GO:0042551]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15291}; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack. {ECO:0000250|UniProtKB:P15291}.
Q9UBY0	reviewed	SL9A2_HUMAN	Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2)	SLC9A2 NHE2	Homo sapiens (Human)	812	FUNCTION: Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity). {ECO:0000250|UniProtKB:Q3ZAS0, ECO:0000269|PubMed:10444453}.		epithelial cell differentiation [GO:0030855]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; protein localization [GO:0008104]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]	potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; epithelial cell differentiation [GO:0030855]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; protein localization [GO:0008104]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:8772498}; Multi-pass membrane protein {ECO:0000255}.
Q9UBY5	reviewed	LPAR3_HUMAN	Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7)	LPAR3 EDG7 LPA3	Homo sapiens (Human)	353	FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bleb assembly [GO:0032060]; chemical synaptic transmission [GO:0007268]; collateral sprouting [GO:0048668]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gene expression [GO:0010467]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; regulation of metabolic process [GO:0019222]	axon [GO:0030424]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; lysophosphatidic acid receptor activity [GO:0070915]	axon [GO:0030424]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; lysophosphatidic acid receptor activity [GO:0070915]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bleb assembly [GO:0032060]; chemical synaptic transmission [GO:0007268]; collateral sprouting [GO:0048668]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gene expression [GO:0010467]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; regulation of metabolic process [GO:0019222]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9UBY8	reviewed	CLN8_HUMAN	Protein CLN8	CLN8 C8orf61	Homo sapiens (Human)	286	FUNCTION: Could play a role in cell proliferation during neuronal differentiation and in protection against cell death. {ECO:0000269|PubMed:19431184}.		adult walking behavior [GO:0007628]; associative learning [GO:0008306]; ceramide biosynthetic process [GO:0046513]; ceramide metabolic process [GO:0006672]; cholesterol metabolic process [GO:0008203]; glutamate reuptake [GO:0051935]; lipid biosynthetic process [GO:0008610]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; lysosome organization [GO:0007040]; mitochondrial membrane organization [GO:0007006]; musculoskeletal movement [GO:0050881]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of proteolysis [GO:0045861]; nervous system development [GO:0007399]; neurofilament cytoskeleton organization [GO:0060052]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; phospholipid metabolic process [GO:0006644]; photoreceptor cell maintenance [GO:0045494]; protein catabolic process [GO:0030163]; regulation of cell size [GO:0008361]; retina development in camera-type eye [GO:0060041]; retinal rod cell apoptotic process [GO:0097473]; social behavior [GO:0035176]; somatic motor neuron differentiation [GO:0021523]; visual perception [GO:0007601]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; mitochondrion [GO:0005739]; presynapse [GO:0098793]	ceramide binding [GO:0097001]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; mitochondrion [GO:0005739]; presynapse [GO:0098793]; ceramide binding [GO:0097001]; adult walking behavior [GO:0007628]; associative learning [GO:0008306]; ceramide biosynthetic process [GO:0046513]; ceramide metabolic process [GO:0006672]; cholesterol metabolic process [GO:0008203]; glutamate reuptake [GO:0051935]; lipid biosynthetic process [GO:0008610]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; lysosome organization [GO:0007040]; mitochondrial membrane organization [GO:0007006]; musculoskeletal movement [GO:0050881]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of proteolysis [GO:0045861]; nervous system development [GO:0007399]; neurofilament cytoskeleton organization [GO:0060052]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; phospholipid metabolic process [GO:0006644]; photoreceptor cell maintenance [GO:0045494]; protein catabolic process [GO:0030163]; regulation of cell size [GO:0008361]; retina development in camera-type eye [GO:0060041]; retinal rod cell apoptotic process [GO:0097473]; social behavior [GO:0035176]; somatic motor neuron differentiation [GO:0021523]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10861296}; Multi-pass membrane protein {ECO:0000269|PubMed:10861296}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:10861296}; Multi-pass membrane protein {ECO:0000269|PubMed:10861296}. Endoplasmic reticulum {ECO:0000269|PubMed:19941651}.
Q9UBY9	reviewed	HSPB7_HUMAN	Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp)	HSPB7 CVHSP	Homo sapiens (Human)	170		MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	heart development [GO:0007507]; regulation of heart contraction [GO:0008016]; response to unfolded protein [GO:0006986]	actin cytoskeleton [GO:0015629]; aggresome [GO:0016235]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	filamin binding [GO:0031005]	actin cytoskeleton [GO:0015629]; aggresome [GO:0016235]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; filamin binding [GO:0031005]; heart development [GO:0007507]; regulation of heart contraction [GO:0008016]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus {ECO:0000269|PubMed:19464326}. Nucleus, Cajal body {ECO:0000269|PubMed:19464326}. Note=Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Q9UBZ4	reviewed	APEX2_HUMAN	DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2)	APEX2 APE2 APEXL2 XTH2	Homo sapiens (Human)	518	FUNCTION: Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16687656). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities (PubMed:16687656, PubMed:19443450, PubMed:32516598). Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (PubMed:16687656, PubMed:19443450). Also exhibits 3'-5' exonuclease activity on a single nucleotide gap containing heteroduplex DNA and on blunt-ended substrates (PubMed:16687656). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents (PubMed:16687656, PubMed:19443450). In the nucleus functions in the PCNA-dependent BER pathway (PubMed:11376153). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (PubMed:32516598). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). {ECO:0000250|UniProtKB:Q68G58, ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:16687656, ECO:0000269|PubMed:19443450, ECO:0000269|PubMed:32516598}.		base-excision repair [GO:0006284]; cell cycle [GO:0007049]; DNA recombination [GO:0006310]	fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; endonuclease activity [GO:0004519]; phosphoric diester hydrolase activity [GO:0008081]; zinc ion binding [GO:0008270]	fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; endonuclease activity [GO:0004519]; phosphoric diester hydrolase activity [GO:0008081]; zinc ion binding [GO:0008270]; base-excision repair [GO:0006284]; cell cycle [GO:0007049]; DNA recombination [GO:0006310]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00764, ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:19443450}. Cytoplasm. Mitochondrion {ECO:0000305|PubMed:11376153}. Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. {ECO:0000269|PubMed:19443450}.
Q9UBZ9	reviewed	REV1_HUMAN	DNA repair protein REV1 (EC 2.7.7.-) (Alpha integrin-binding protein 80) (AIBP80) (Rev1-like terminal deoxycytidyl transferase)	REV1 REV1L	Homo sapiens (Human)	1251	FUNCTION: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. {ECO:0000269|PubMed:10536157, ECO:0000269|PubMed:10760286, ECO:0000269|PubMed:11278384, ECO:0000269|PubMed:11485998, ECO:0000269|PubMed:22266823}.		DNA replication [GO:0006260]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; response to UV [GO:0009411]	nucleoplasm [GO:0005654]	damaged DNA binding [GO:0003684]; deoxycytidyl transferase activity [GO:0017125]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; damaged DNA binding [GO:0003684]; deoxycytidyl transferase activity [GO:0017125]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; DNA replication [GO:0006260]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; response to UV [GO:0009411]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UC07	reviewed	ZNF69_HUMAN	Zinc finger protein 69 (hZNF3)	ZNF69	Homo sapiens (Human)	566	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UD71	reviewed	PPR1B_HUMAN	Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein)	PPP1R1B DARPP32	Homo sapiens (Human)	204	FUNCTION: Inhibitor of protein-phosphatase 1.		behavioral response to cocaine [GO:0048148]; cellular response to cocaine [GO:0071314]; DNA-templated transcription [GO:0006351]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; negative regulation of female receptivity [GO:0007621]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; response to amphetamine [GO:0001975]; response to morphine [GO:0043278]; signal transduction [GO:0007165]; visual learning [GO:0008542]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]	cAMP-dependent protein kinase inhibitor activity [GO:0004862]; protein kinase inhibitor activity [GO:0004860]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; protein kinase inhibitor activity [GO:0004860]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]; behavioral response to cocaine [GO:0048148]; cellular response to cocaine [GO:0071314]; DNA-templated transcription [GO:0006351]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; negative regulation of female receptivity [GO:0007621]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; response to amphetamine [GO:0001975]; response to morphine [GO:0043278]; signal transduction [GO:0007165]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cytoplasm.
Q9UDR5	reviewed	AASS_HUMAN	Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]	AASS	Homo sapiens (Human)	926	FUNCTION: Bifunctional enzyme that catalyzes the first two steps in lysine degradation. {ECO:0000269|PubMed:10775527, ECO:0000269|PubMed:463877}.		L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; lysine biosynthetic process via aminoadipic acid [GO:0019878]; lysine catabolic process [GO:0006554]; negative regulation of transcription by RNA polymerase II [GO:0000122]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	histone binding [GO:0042393]; saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity [GO:0047131]; saccharopine dehydrogenase (NAD+, L-lysine-forming) activity [GO:0004754]; saccharopine dehydrogenase (NADP+, L-lysine-forming) activity [GO:0047130]; saccharopine dehydrogenase activity [GO:0004753]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; histone binding [GO:0042393]; saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity [GO:0047131]; saccharopine dehydrogenase (NAD+, L-lysine-forming) activity [GO:0004754]; saccharopine dehydrogenase (NADP+, L-lysine-forming) activity [GO:0047130]; saccharopine dehydrogenase activity [GO:0004753]; transcription corepressor activity [GO:0003714]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; lysine biosynthetic process via aminoadipic acid [GO:0019878]; lysine catabolic process [GO:0006554]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:463877}.
Q9UDT6	reviewed	CLIP2_HUMAN	CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein)	CLIP2 CYLN2 KIAA0291 WBSCR3 WBSCR4 WSCR4	Homo sapiens (Human)	1046	FUNCTION: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.		cytoplasmic microtubule organization [GO:0031122]	cell cortex [GO:0005938]; microtubule associated complex [GO:0005875]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]	microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]	cell cortex [GO:0005938]; microtubule associated complex [GO:0005875]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; cytoplasmic microtubule organization [GO:0031122]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O55156}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Z0H8}. Note=Localizes preferentially to the ends of tyrosinated microtubules. {ECO:0000250|UniProtKB:Q9Z0H8}.
Q9UDV6	reviewed	ZN212_HUMAN	Zinc finger protein 212 (Zinc finger protein C2H2-150)	ZNF212 ZNFC150	Homo sapiens (Human)	495	FUNCTION: May be involved in transcriptional regulation.		dendrite development [GO:0016358]; general adaptation syndrome, behavioral process [GO:0051867]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to alcohol [GO:0097305]; walking behavior [GO:0090659]	nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; dendrite development [GO:0016358]; general adaptation syndrome, behavioral process [GO:0051867]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to alcohol [GO:0097305]; walking behavior [GO:0090659]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UDW1	reviewed	QCR9_HUMAN	Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein)	UQCR10 UCRC HSPC119	Homo sapiens (Human)	63	FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000250|UniProtKB:P22289}.		cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]	ubiquinol-cytochrome-c reductase activity [GO:0008121]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P22289}; Single-pass membrane protein {ECO:0000250|UniProtKB:P22289}.
Q9UDW3	reviewed	ZMAT5_HUMAN	Zinc finger matrin-type protein 5 (U11/U12 small nuclear ribonucleoprotein 20 kDa protein) (U11/U12 snRNP 20 kDa protein) (U11/U12-20K)	ZMAT5	Homo sapiens (Human)	170			mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689]	zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689]; zinc ion binding [GO:0008270]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15146077}.
Q9UDX3	reviewed	S14L4_HUMAN	SEC14-like protein 4 (Tocopherol-associated protein 3)	SEC14L4 TAP3	Homo sapiens (Human)	406	FUNCTION: Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.			cytoplasm [GO:0005737]	lipid binding [GO:0008289]	cytoplasm [GO:0005737]; lipid binding [GO:0008289]	
Q9UDY2	reviewed	ZO2_HUMAN	Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)	TJP2 X104 ZO2	Homo sapiens (Human)	1190	FUNCTION: Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}.	MISCELLANEOUS: [Isoform A1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform A2]: Produced by alternative splicing of isoform A1. {ECO:0000305}.; MISCELLANEOUS: [Isoform A3]: Produced by alternative splicing of isoform A1. {ECO:0000305}.; MISCELLANEOUS: [Isoform C1]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform C2]: Produced by alternative splicing of isoform C1. {ECO:0000305}.	cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; homotypic cell-cell adhesion [GO:0034109]; intestinal absorption [GO:0050892]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105]; regulation of membrane permeability [GO:0090559]; response to organic substance [GO:0010033]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell-cell contact zone [GO:0044291]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; guanylate kinase activity [GO:0004385]; protein domain specific binding [GO:0019904]; protein tyrosine kinase binding [GO:1990782]; protein-macromolecule adaptor activity [GO:0030674]; transmembrane transporter binding [GO:0044325]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell-cell contact zone [GO:0044291]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; guanylate kinase activity [GO:0004385]; protein domain specific binding [GO:0019904]; protein tyrosine kinase binding [GO:1990782]; protein-macromolecule adaptor activity [GO:0030674]; transmembrane transporter binding [GO:0044325]; cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; homotypic cell-cell adhesion [GO:0034109]; intestinal absorption [GO:0050892]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105]; regulation of membrane permeability [GO:0090559]; response to organic substance [GO:0010033]	SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Z0U1}. Nucleus {ECO:0000250}. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. {ECO:0000250}.
Q9UDY4	reviewed	DNJB4_HUMAN	DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein)	DNAJB4 DNAJW HLJ1	Homo sapiens (Human)	337	FUNCTION: Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}.		chaperone cofactor-dependent protein refolding [GO:0051085]; negative regulation of transcription by RNA polymerase II [GO:0000122]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ATPase activator activity [GO:0001671]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ATPase activator activity [GO:0001671]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; chaperone cofactor-dependent protein refolding [GO:0051085]; negative regulation of transcription by RNA polymerase II [GO:0000122]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18837411}. Cell membrane {ECO:0000269|PubMed:16542645}. Note=Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.
Q9UDY6	reviewed	TRI10_HUMAN	Tripartite motif-containing protein 10 (B30-RING finger protein) (RING finger protein 9)	TRIM10 RFB30 RNF9	Homo sapiens (Human)	481	FUNCTION: E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (PubMed:33811647). {ECO:0000250|UniProtKB:Q9WUH5, ECO:0000269|PubMed:33811647}.		erythrocyte differentiation [GO:0030218]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; erythrocyte differentiation [GO:0030218]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11331580, ECO:0000269|PubMed:33811647}.
Q9UDY8	reviewed	MALT1_HUMAN	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase)	MALT1 MLT	Homo sapiens (Human)	824	FUNCTION: Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475). {ECO:0000250|UniProtKB:Q2TBA3, ECO:0000269|PubMed:11262391, ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:31133753}.		activation of NF-kappaB-inducing kinase activity [GO:0007250]; B cell activation [GO:0042113]; B-1 B cell differentiation [GO:0001923]; defense response [GO:0006952]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of apoptotic process [GO:0043066]; nuclear export [GO:0051168]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T-helper 17 cell differentiation [GO:2000321]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; regulation of T cell receptor signaling pathway [GO:0050856]; response to fungus [GO:0009620]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]	CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polkadots [GO:0002096]; protein-containing complex [GO:0032991]	cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; protein self-association [GO:0043621]; small molecule binding [GO:0036094]; ubiquitin-protein transferase activity [GO:0004842]	CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polkadots [GO:0002096]; protein-containing complex [GO:0032991]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; protein self-association [GO:0043621]; small molecule binding [GO:0036094]; ubiquitin-protein transferase activity [GO:0004842]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; B cell activation [GO:0042113]; B-1 B cell differentiation [GO:0001923]; defense response [GO:0006952]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of apoptotic process [GO:0043066]; nuclear export [GO:0051168]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T-helper 17 cell differentiation [GO:2000321]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; regulation of T cell receptor signaling pathway [GO:0050856]; response to fungus [GO:0009620]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:16123224}. Nucleus {ECO:0000269|PubMed:16123224}. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. {ECO:0000269|PubMed:16123224}.
Q9UEE5	reviewed	ST17A_HUMAN	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1)	STK17A DRAK1	Homo sapiens (Human)	414	FUNCTION: Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. {ECO:0000269|PubMed:21489989, ECO:0000269|PubMed:9786912}.		apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast apoptotic process [GO:2000271]; protein phosphorylation [GO:0006468]; regulation of reactive oxygen species metabolic process [GO:2000377]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast apoptotic process [GO:2000271]; protein phosphorylation [GO:0006468]; regulation of reactive oxygen species metabolic process [GO:2000377]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9786912}.
Q9UEF7	reviewed	KLOT_HUMAN	Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide]	KL	Homo sapiens (Human)	1012	FUNCTION: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). {ECO:0000250}.; FUNCTION: The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. {ECO:0000250}.	MISCELLANEOUS: Defects in KL may be a cause of chronic renal failure complications.; MISCELLANEOUS: [Isoform 2]: Predominates over the membrane form in all tissues examined. {ECO:0000305}.	calcium ion homeostasis [GO:0055074]; carbohydrate metabolic process [GO:0005975]; determination of adult lifespan [GO:0008340]; energy reserve metabolic process [GO:0006112]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of systemic arterial blood pressure [GO:0003085]; norepinephrine biosynthetic process [GO:0042421]; positive regulation of bone mineralization [GO:0030501]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; response to activity [GO:0014823]; response to angiotensin [GO:1990776]; response to vitamin D [GO:0033280]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]	beta-glucosidase activity [GO:0008422]; beta-glucuronidase activity [GO:0004566]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor binding [GO:0005104]; hormone activity [GO:0005179]; vitamin D binding [GO:0005499]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; beta-glucosidase activity [GO:0008422]; beta-glucuronidase activity [GO:0004566]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor binding [GO:0005104]; hormone activity [GO:0005179]; vitamin D binding [GO:0005499]; calcium ion homeostasis [GO:0055074]; carbohydrate metabolic process [GO:0005975]; determination of adult lifespan [GO:0008340]; energy reserve metabolic process [GO:0006112]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of systemic arterial blood pressure [GO:0003085]; norepinephrine biosynthetic process [GO:0042421]; positive regulation of bone mineralization [GO:0030501]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; response to activity [GO:0014823]; response to angiotensin [GO:1990776]; response to vitamin D [GO:0033280]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:15135068}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:O35082}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O35082}. Note=Isoform 1 shedding leads to a soluble peptide. {ECO:0000250|UniProtKB:O35082}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:15135068}.; SUBCELLULAR LOCATION: [Klotho peptide]: Secreted {ECO:0000250|UniProtKB:O35082}.
Q9UEG4	reviewed	ZN629_HUMAN	Zinc finger protein 629 (Zinc finger protein 65)	ZNF629 KIAA0326 ZNF65	Homo sapiens (Human)	869	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UER7	reviewed	DAXX_HUMAN	Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein)	DAXX BING2 DAP6	Homo sapiens (Human)	740	FUNCTION: Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}.	MISCELLANEOUS: [Isoform beta]: Markedly decreased affinity for PML and TP53/p53, unable to repress p53-mediated transcription. {ECO:0000305}.; MISCELLANEOUS: [Isoform gamma]: Markedly decreased affinity for PML and TP53/p53, unable to repress p53-mediated transcription. {ECO:0000305}.	androgen receptor signaling pathway [GO:0030521]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to diamide [GO:0072738]; cellular response to heat [GO:0034605]; cellular response to sodium arsenite [GO:1903936]; cellular response to unfolded protein [GO:0034620]; chromatin remodeling [GO:0006338]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; JNK cascade [GO:0007254]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; neuron intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0036480]; nucleosome assembly [GO:0006334]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of protein ubiquitination [GO:0031396]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; histone binding [GO:0042393]; molecular condensate scaffold activity [GO:0140693]; nuclear androgen receptor binding [GO:0050681]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sumo-dependent protein binding [GO:0140037]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin protein ligase binding [GO:0031625]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; histone binding [GO:0042393]; molecular condensate scaffold activity [GO:0140693]; nuclear androgen receptor binding [GO:0050681]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sumo-dependent protein binding [GO:0140037]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin protein ligase binding [GO:0031625]; androgen receptor signaling pathway [GO:0030521]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to diamide [GO:0072738]; cellular response to heat [GO:0034605]; cellular response to sodium arsenite [GO:1903936]; cellular response to unfolded protein [GO:0034620]; chromatin remodeling [GO:0006338]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; JNK cascade [GO:0007254]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; neuron intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0036480]; nucleosome assembly [GO:0006334]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of protein ubiquitination [GO:0031396]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11495919, ECO:0000269|PubMed:11842083, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:9407001}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10669754, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:9407001}. Nucleus, PML body {ECO:0000269|PubMed:10669754, ECO:0000269|PubMed:11842083, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:21482821, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:25275136}. Nucleus, nucleolus {ECO:0000269|PubMed:23222847}. Chromosome, centromere {ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:9645950}. Note=Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli (Probable). Colocalizes with histone H3.3, ATRX, HIRA and ASF1A at PML-nuclear bodies (PubMed:12953102, PubMed:14990586, PubMed:23222847, PubMed:24200965). Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres (PubMed:9645950). Detected in cytoplasmic punctate structures (PubMed:11842083). Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress (PubMed:12968034). Colocalizes with RASSF1 in the nucleus (PubMed:18566590). Colocalizes with USP7 in nucleoplasma with accumulation in speckled structures (PubMed:16845383). {ECO:0000269|PubMed:11842083, ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:9645950, ECO:0000305|PubMed:10669754}.; SUBCELLULAR LOCATION: [Isoform beta]: Nucleus {ECO:0000269|PubMed:21482821}. Note=Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1. {ECO:0000269|PubMed:21482821}.; SUBCELLULAR LOCATION: [Isoform gamma]: Nucleus {ECO:0000269|PubMed:21482821}. Note=Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1. {ECO:0000269|PubMed:21482821}.
Q9UET6	reviewed	TRM7_HUMAN	tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1)	FTSJ1 JM23	Homo sapiens (Human)	329	FUNCTION: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:32558197, PubMed:32198346, PubMed:33771871, PubMed:26310293, PubMed:36720500). Requisite for faithful cytoplasmic translation (PubMed:32393790). Requires THADA for methylation of the nucleotide at position 32 of the anticodon loop of substrate tRNAs (PubMed:26310293, PubMed:25404562). Requires WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Promotes translation efficiency of the UUU codon (PubMed:32558197). Plays a role in neurogenesis (PubMed:36720500). Required for expression of genes involved in neurogenesis, mitochondrial translation and energy generation, and lipid biosynthesis (PubMed:36720500, PubMed:33771871). Requisite for RNA-mediated gene silencing (PubMed:36720500). May modify position 32 in tRNA(Arg(ACG)), tRNA(Arg(CCG)), tRNA(Arg(UCG)), tRNA(Cys(GCA)), tRNA(Cys(ACA)), tRNA(Gln(CUG)), tRNA(Gln(UUG)), tRNA(Gly(CCC)), tRNA(Leu(CAG))/tRNA(Leu(CAA)), tRNA(Leu(A/IAG)), tRNA(Leu(UAG)), tRNA(Phe(GAA)), tRNA(Pro(AGG))/tRNA(Pro(CGG))/tRNA(Pro(UGG)) and tRNA(Trp(CCA)), and position 34 in tRNA(Phe(GAA)), tRNA(Leu(CAA)), tRNA(Sec(UCA)), and tRNA(Trp(CCA)) (PubMed:32558197, PubMed:32198346, PubMed:33771871, PubMed:26310293, PubMed:36720500). {ECO:0000269|PubMed:25404562, ECO:0000269|PubMed:26310293, ECO:0000269|PubMed:32198346, ECO:0000269|PubMed:32393790, ECO:0000269|PubMed:32558197, ECO:0000269|PubMed:33771871, ECO:0000269|PubMed:36720500}.		cytoplasmic translation [GO:0002181]; neurogenesis [GO:0022008]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA nucleoside ribose methylation [GO:0002128]; wobble position ribose methylation [GO:0002130]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	S-adenosyl-L-methionine binding [GO:1904047]; tRNA (cytidine 32-2'-O)-methyltransferase activity [GO:0106339]; tRNA (cytosine-2'-O-)-methyltransferase activity [GO:0052666]; tRNA (guanine) methyltransferase activity [GO:0016423]; tRNA (guanosine-2'-O-)-methyltransferase activity [GO:0009020]; tRNA methyltransferase activity [GO:0008175]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; S-adenosyl-L-methionine binding [GO:1904047]; tRNA (cytidine 32-2'-O)-methyltransferase activity [GO:0106339]; tRNA (cytosine-2'-O-)-methyltransferase activity [GO:0052666]; tRNA (guanine) methyltransferase activity [GO:0016423]; tRNA (guanosine-2'-O-)-methyltransferase activity [GO:0009020]; tRNA methyltransferase activity [GO:0008175]; cytoplasmic translation [GO:0002181]; neurogenesis [GO:0022008]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA nucleoside ribose methylation [GO:0002128]; wobble position ribose methylation [GO:0002130]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32558197}. Nucleus {ECO:0000269|PubMed:32558197}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:32558197}.
Q9UEU0	reviewed	VTI1B_HUMAN	Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1)	VTI1B VTI1 VTI1L VTI1L1 VTI2	Homo sapiens (Human)	232	FUNCTION: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. {ECO:0000269|PubMed:23217709}.		Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; membrane fusion [GO:0061025]; regulation of protein localization to plasma membrane [GO:1903076]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion with Golgi apparatus [GO:0048280]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule lumen [GO:0031093]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]	chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule lumen [GO:0031093]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]; chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; membrane fusion [GO:0061025]; regulation of protein localization to plasma membrane [GO:1903076]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion with Golgi apparatus [GO:0048280]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:18033301}; Single-pass type IV membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:18033301, ECO:0000269|PubMed:23217709}; Single-pass type IV membrane protein {ECO:0000269|PubMed:23217709}. Lysosome membrane {ECO:0000269|PubMed:18033301, ECO:0000269|PubMed:23217709}. Cytoplasmic granule {ECO:0000269|PubMed:23217709}. Recycling endosome membrane {ECO:0000269|PubMed:18033301}; Single-pass type IV membrane protein {ECO:0000255}.
Q9UEW3	reviewed	MARCO_HUMAN	Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2)	MARCO SCARA2	Homo sapiens (Human)	520	FUNCTION: Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263). {ECO:0000250|UniProtKB:Q9WUB9, ECO:0000269|PubMed:12847263, ECO:0000269|PubMed:9468508}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; amyloid-beta clearance [GO:0097242]; apoptotic cell clearance [GO:0043277]; cell surface receptor signaling pathway [GO:0007166]; innate immune response [GO:0045087]; phagocytosis, engulfment [GO:0006911]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein phosphorylation [GO:0001934]; receptor-mediated endocytosis [GO:0006898]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; plasma membrane [GO:0005886]	amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; G protein-coupled receptor binding [GO:0001664]; pattern recognition receptor activity [GO:0038187]; transmembrane signaling receptor activity [GO:0004888]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; plasma membrane [GO:0005886]; amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; G protein-coupled receptor binding [GO:0001664]; pattern recognition receptor activity [GO:0038187]; transmembrane signaling receptor activity [GO:0004888]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; amyloid-beta clearance [GO:0097242]; apoptotic cell clearance [GO:0043277]; cell surface receptor signaling pathway [GO:0007166]; innate immune response [GO:0045087]; phagocytosis, engulfment [GO:0006911]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein phosphorylation [GO:0001934]; receptor-mediated endocytosis [GO:0006898]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9468508}; Single-pass type II membrane protein {ECO:0000305}.
Q9UEW8	reviewed	STK39_HUMAN	STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39)	STK39 PASK SPAK	Homo sapiens (Human)	545	FUNCTION: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}.		cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular hypotonic response [GO:0071476]; cellular response to chemokine [GO:1990869]; cellular response to potassium ion [GO:0035865]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; inflammatory response [GO:0006954]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; macrophage activation [GO:0042116]; maintenance of lens transparency [GO:0036438]; negative regulation of creatine transmembrane transporter activity [GO:1905408]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of T cell chemotaxis [GO:0010820]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; renal sodium ion absorption [GO:0070294]; response to aldosterone [GO:1904044]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular hypotonic response [GO:0071476]; cellular response to chemokine [GO:1990869]; cellular response to potassium ion [GO:0035865]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; inflammatory response [GO:0006954]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; macrophage activation [GO:0042116]; maintenance of lens transparency [GO:0036438]; negative regulation of creatine transmembrane transporter activity [GO:1905408]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of T cell chemotaxis [GO:0010820]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; renal sodium ion absorption [GO:0070294]; response to aldosterone [GO:1904044]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Nucleus when caspase-cleaved. {ECO:0000305}.
Q9UEY8	reviewed	ADDG_HUMAN	Gamma-adducin (Adducin-like protein 70)	ADD3 ADDL	Homo sapiens (Human)	706	FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}.		barbed-end actin filament capping [GO:0051016]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of vasoconstriction [GO:0045907]; response to xenobiotic stimulus [GO:0009410]	brush border [GO:0005903]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; condensed nuclear chromosome [GO:0000794]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; protein kinase C binding [GO:0005080]; structural constituent of cytoskeleton [GO:0005200]	brush border [GO:0005903]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; condensed nuclear chromosome [GO:0000794]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; protein kinase C binding [GO:0005080]; structural constituent of cytoskeleton [GO:0005200]; barbed-end actin filament capping [GO:0051016]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of vasoconstriction [GO:0045907]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q62847}. Cell membrane {ECO:0000250|UniProtKB:Q62847}; Peripheral membrane protein; Cytoplasmic side. Cytoplasm {ECO:0000250|UniProtKB:Q9QYB5}. Note=Full-length protein and the cleavage fragment 358-706 localize mainly to the cytoplasm, while cleavage fragment 1-357 translocates from the cytoplasm to the nucleus. {ECO:0000250|UniProtKB:Q9QYB5}.
Q9UF11	reviewed	PKHB1_HUMAN	Pleckstrin homology domain-containing family B member 1 (PH domain-containing family B member 1) (Evectin-1) (PH domain-containing protein in retina 1) (PHRET1) (Pleckstrin homology domain retinal protein 1)	PLEKHB1 EVT1 KPL1 PHR1 PHRET1	Homo sapiens (Human)	243			phototransduction [GO:0007602]; regulation of cell differentiation [GO:0045595]	cytoplasm [GO:0005737]; membrane [GO:0016020]		cytoplasm [GO:0005737]; membrane [GO:0016020]; phototransduction [GO:0007602]; regulation of cell differentiation [GO:0045595]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10585447}. Cytoplasm {ECO:0000250|UniProtKB:Q9QYE9}. Note=Localizes to the apical juxta-nuclear Golgi region of the cytoplasm (By similarity). Membrane-associated (PubMed:10585447). Highly expressed in the outer segments of photoreceptor cells, both in rods and cones (PubMed:10585447). {ECO:0000250|UniProtKB:Q9QYE9, ECO:0000269|PubMed:10585447}.
Q9UF12	reviewed	HYPDH_HUMAN	Hydroxyproline dehydrogenase (HYPDH) (EC 1.5.5.3) (Kidney and liver proline oxidase 1) (HsPOX1) (Probable proline dehydrogenase 2) (EC 1.5.5.2) (Probable proline oxidase 2)	PRODH2 HSPOX1 HYPDH	Homo sapiens (Human)	460	FUNCTION: Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis. {ECO:0000269|PubMed:25697095}.		proline catabolic process [GO:0006562]; proline catabolic process to glutamate [GO:0010133]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-NH group of donors [GO:0016645]; proline dehydrogenase activity [GO:0004657]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-NH group of donors [GO:0016645]; proline dehydrogenase activity [GO:0004657]; proline catabolic process [GO:0006562]; proline catabolic process to glutamate [GO:0010133]	
Q9UF33	reviewed	EPHA6_HUMAN	Ephrin type-A receptor 6 (EC 2.7.10.1) (EPH homology kinase 2) (EHK-2) (EPH-like kinase 12) (EK12)	EPHA6 EHK2 HEK12	Homo sapiens (Human)	1036	FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; phosphorylation [GO:0016310]	dendrite [GO:0030425]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; transmembrane-ephrin receptor activity [GO:0005005]	dendrite [GO:0030425]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; transmembrane-ephrin receptor activity [GO:0005005]; axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9UF56	reviewed	FXL17_HUMAN	F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13)	FBXL17 FBL17 FBX13 FBXO13	Homo sapiens (Human)	701	FUNCTION: Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity). {ECO:0000250|UniProtKB:B1H1X1, ECO:0000250|UniProtKB:Q9QZN1, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:27234298, ECO:0000269|PubMed:30190310}.		entrainment of circadian clock by photoperiod [GO:0043153]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein ubiquitination [GO:0016567]; regulation of smoothened signaling pathway [GO:0008589]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; entrainment of circadian clock by photoperiod [GO:0043153]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein ubiquitination [GO:0016567]; regulation of smoothened signaling pathway [GO:0008589]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24035498}. Nucleus {ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:27234298}. Note=Present in the cytoplasm and nucleus; more abundant in the cytoplasm. {ECO:0000269|PubMed:24035498}.
Q9UFB7	reviewed	ZBT47_HUMAN	Zinc finger and BTB domain-containing protein 47 (Zinc finger protein 651)	ZBTB47 KIAA1190 ZNF651	Homo sapiens (Human)	747	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UFC0	reviewed	LRWD1_HUMAN	Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA)	LRWD1 CENP-33 ORCA	Homo sapiens (Human)	647	FUNCTION: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. {ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:20932478, ECO:0000269|PubMed:21029866, ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22645314}.		chromatin organization [GO:0006325]; DNA replication initiation [GO:0006270]; establishment of protein localization to chromatin [GO:0071169]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; microtubule organizing center [GO:0005815]; nuclear origin of replication recognition complex [GO:0005664]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	chromatin binding [GO:0003682]; methyl-CpG binding [GO:0008327]; methylated histone binding [GO:0035064]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; microtubule organizing center [GO:0005815]; nuclear origin of replication recognition complex [GO:0005664]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; chromatin binding [GO:0003682]; methyl-CpG binding [GO:0008327]; methylated histone binding [GO:0035064]; chromatin organization [GO:0006325]; DNA replication initiation [GO:0006270]; establishment of protein localization to chromatin [GO:0071169]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18445686}. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8BUI3}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3.
Q9UFD9	reviewed	RIM3A_HUMAN	RIMS-binding protein 3A (RIM-BP3.A) (RIMS-binding protein 3.1) (RIM-BP3.1)	RIMBP3 KIAA1666 RIMBP3A	Homo sapiens (Human)	1639	FUNCTION: Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}.		fertilization [GO:0009566]; spermatid development [GO:0007286]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]	benzodiazepine receptor binding [GO:0030156]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; benzodiazepine receptor binding [GO:0030156]; fertilization [GO:0009566]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q3V0F0}. Note=In elongating spermatids, localizes to the manchette. {ECO:0000250|UniProtKB:Q3V0F0}.
Q9UFE4	reviewed	CCD39_HUMAN	Coiled-coil domain-containing protein 39	CCDC39	Homo sapiens (Human)	941	FUNCTION: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131972). Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly (PubMed:21131972). {ECO:0000250|UniProtKB:A8IQT2, ECO:0000269|PubMed:21131972}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	axonemal dynein complex assembly [GO:0070286]; brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; cilium-dependent cell motility [GO:0060285]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment of left/right asymmetry [GO:0061966]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; protein localization to cilium [GO:0061512]; regulation of cilium beat frequency [GO:0003356]	axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]		axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; axonemal dynein complex assembly [GO:0070286]; brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; cilium-dependent cell motility [GO:0060285]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment of left/right asymmetry [GO:0061966]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; protein localization to cilium [GO:0061512]; regulation of cilium beat frequency [GO:0003356]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:21131972, ECO:0000269|PubMed:21131974, ECO:0000269|PubMed:27120127}. Note=CCDC40 is required for localization to axonemes. {ECO:0000269|PubMed:21131974}.
Q9UFF9	reviewed	CNOT8_HUMAN	CCR4-NOT transcription complex subunit 8 (EC 3.1.13.4) (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8) (Caf1b)	CNOT8 CALIF POP2	Homo sapiens (Human)	292	FUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:23236473}.		exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mRNA catabolic process [GO:0061014]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]	3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mRNA catabolic process [GO:0061014]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12771185}. Nucleus {ECO:0000269|PubMed:12771185}.
Q9UFG5	reviewed	CS025_HUMAN	UPF0449 protein C19orf25	C19orf25	Homo sapiens (Human)	118							
Q9UFH2	reviewed	DYH17_HUMAN	Dynein axonemal heavy chain 17 (Axonemal beta dynein heavy chain 17) (Axonemal dynein heavy chain-like protein 1) (Ciliary dynein heavy chain 17) (Ciliary dynein heavy chain-like protein 1) (Dynein axonemal light chain 2)	DNAH17 DNAHL1 DNEL2	Homo sapiens (Human)	4462	FUNCTION: Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (Probable). Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating (PubMed:31178125). {ECO:0000269|PubMed:31178125, ECO:0000305|PubMed:31178125}.	MISCELLANEOUS: [Isoform 1]: Gene prediction based on partial mRNA data. {ECO:0000305}.	cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; outer dynein arm assembly [GO:0036158]	9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126]	ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126]; ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]; cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; outer dynein arm assembly [GO:0036158]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:31178125}.
Q9UFP1	reviewed	GAK1A_HUMAN	Golgi-associated kinase 1A (Protein FAM198A)	GASK1A C3orf41 FAM198A	Homo sapiens (Human)	575				caveola [GO:0005901]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]		caveola [GO:0005901]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q3UY90}. Golgi apparatus {ECO:0000250|UniProtKB:Q3UY90}. Membrane, caveola {ECO:0000269|PubMed:30188967}. Note=Requires caveolae biogenesis to be secreted from the endoplasmic reticulum going through the Golgi apparatus where is post-translationally processed to the mature form. {ECO:0000250|UniProtKB:Q3UY90}.
Q9UFW8	reviewed	CGBP1_HUMAN	CGG triplet repeat-binding protein 1 (CGG-binding protein 1) (20 kDa CGG-binding protein) (p20-CGGBP DNA-binding protein)	CGGBP1 CGGBP	Homo sapiens (Human)	167	FUNCTION: Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. {ECO:0000269|PubMed:9201980}.	MISCELLANEOUS: Binding is severely inhibited by complete or partial cytosine-specific DNA methylation of the binding motif.	epigenetic regulation of gene expression [GO:0040029]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gene expression [GO:0010468]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9201980}.
Q9UG01	reviewed	IF172_HUMAN	Intraflagellar transport protein 172 homolog	IFT172 KIAA1179	Homo sapiens (Human)	1749	FUNCTION: Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity). {ECO:0000250}.		bone development [GO:0060348]; brain development [GO:0007420]; cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; dorsal/ventral pattern formation [GO:0009953]; embryonic camera-type eye morphogenesis [GO:0048596]; epidermis development [GO:0008544]; heart looping [GO:0001947]; hindgut development [GO:0061525]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; keratinocyte proliferation [GO:0043616]; left/right axis specification [GO:0070986]; limb development [GO:0060173]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of smoothened signaling pathway [GO:0045879]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; Notch signaling pathway [GO:0007219]; positive regulation of smoothened signaling pathway [GO:0045880]; protein processing [GO:0016485]; roof of mouth development [GO:0060021]; smoothened signaling pathway [GO:0007224]; spinal cord motor neuron differentiation [GO:0021522]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; extracellular vesicle [GO:1903561]; intraciliary transport particle B [GO:0030992]; sperm cytoplasmic droplet [GO:0097598]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]		axoneme [GO:0005930]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; extracellular vesicle [GO:1903561]; intraciliary transport particle B [GO:0030992]; sperm cytoplasmic droplet [GO:0097598]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; bone development [GO:0060348]; brain development [GO:0007420]; cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; dorsal/ventral pattern formation [GO:0009953]; embryonic camera-type eye morphogenesis [GO:0048596]; epidermis development [GO:0008544]; heart looping [GO:0001947]; hindgut development [GO:0061525]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; keratinocyte proliferation [GO:0043616]; left/right axis specification [GO:0070986]; limb development [GO:0060173]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of smoothened signaling pathway [GO:0045879]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; Notch signaling pathway [GO:0007219]; positive regulation of smoothened signaling pathway [GO:0045880]; protein processing [GO:0016485]; roof of mouth development [GO:0060021]; smoothened signaling pathway [GO:0007224]; spinal cord motor neuron differentiation [GO:0021522]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:24140113}. Note=Localized to the axoneme and around the base of the cilium.
Q9UG22	reviewed	GIMA2_HUMAN	GTPase IMAP family member 2 (Immunity-associated protein 2) (hIMAP2)	GIMAP2 IMAP2	Homo sapiens (Human)	337	FUNCTION: The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. {ECO:0000269|PubMed:23454188}.			endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]	GTP binding [GO:0005525]; identical protein binding [GO:0042802]	endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:23454188}.
Q9UG56	reviewed	PISD_HUMAN	Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain]	PISD	Homo sapiens (Human)	409	FUNCTION: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) (PubMed:30488656, PubMed:30858161). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity). {ECO:0000250|UniProtKB:A0A8H4BVL9, ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:30488656, ECO:0000269|PubMed:30858161}.		lipid droplet formation [GO:0140042]; mitochondrial protein catabolic process [GO:0035694]; phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540]; regulation of mitochondrion organization [GO:0010821]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	phosphatidylserine decarboxylase activity [GO:0004609]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; phosphatidylserine decarboxylase activity [GO:0004609]; lipid droplet formation [GO:0140042]; mitochondrial protein catabolic process [GO:0035694]; phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540]; regulation of mitochondrion organization [GO:0010821]	SUBCELLULAR LOCATION: [Phosphatidylserine decarboxylase beta chain]: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000305|PubMed:30858161, ECO:0000305|PubMed:33718843}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03208}; Intermembrane side {ECO:0000255|HAMAP-Rule:MF_03208}.; SUBCELLULAR LOCATION: [Phosphatidylserine decarboxylase alpha chain]: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000305|PubMed:30858161, ECO:0000305|PubMed:33718843}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03208}; Intermembrane side {ECO:0000255|HAMAP-Rule:MF_03208}. Cytoplasm {ECO:0000269|PubMed:33593792}. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain. {ECO:0000255|HAMAP-Rule:MF_03208}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane {ECO:0000269|PubMed:33593792}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion inner membrane {ECO:0000269|PubMed:33593792}. Lipid droplet {ECO:0000269|PubMed:33593792}. Note=Predominantly localizes to lipid droplets in lipid-replete conditions, and to mitochondria in lipid-deplete conditions. {ECO:0000269|PubMed:33593792}.
Q9UGB7	reviewed	MIOX_HUMAN	Inositol oxygenase (EC 1.13.99.1) (Aldehyde reductase-like 6) (Kidney-specific protein 32) (Myo-inositol oxygenase) (MI oxygenase) (Renal-specific oxidoreductase)	MIOX ALDRL6 KSP32 RSOR	Homo sapiens (Human)	285			inositol catabolic process [GO:0019310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]	aldo-keto reductase (NADP) activity [GO:0004033]; ferric iron binding [GO:0008199]; inositol oxygenase activity [GO:0050113]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [GO:0016701]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; aldo-keto reductase (NADP) activity [GO:0004033]; ferric iron binding [GO:0008199]; inositol oxygenase activity [GO:0050113]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [GO:0016701]; inositol catabolic process [GO:0019310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9UGC6	reviewed	RGS17_HUMAN	Regulator of G-protein signaling 17 (RGS17)	RGS17 RGSZ2	Homo sapiens (Human)	210	FUNCTION: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). {ECO:0000250|UniProtKB:Q9QZB0, ECO:0000269|PubMed:15096504}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; response to amphetamine [GO:0001975]	cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; response to amphetamine [GO:0001975]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9QZB0}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q9QZB0}. Nucleus {ECO:0000250|UniProtKB:Q9QZB0}. Cytoplasm {ECO:0000250|UniProtKB:Q9QZB0}.
Q9UGC7	reviewed	RF1ML_HUMAN	Peptide chain release factor 1-like, mitochondrial (Mitochondrial translational release factor 1-like) (mtRF1a)	MTRF1L MTRF1A	Homo sapiens (Human)	380	FUNCTION: Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG. {ECO:0000269|PubMed:17803939, ECO:0000269|PubMed:33878294, ECO:0000269|PubMed:37141370}.		mitochondrial translational termination [GO:0070126]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]; mitochondrial translational termination [GO:0070126]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:17803939}.
Q9UGH3	reviewed	S23A2_HUMAN	Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2)	SLC23A2 KIAA0238 NBTL1 SLC23A1 SVCT2 YSPL2	Homo sapiens (Human)	650	FUNCTION: Sodium/ascorbate cotransporter (PubMed:10471399, PubMed:10556521). Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10471399). {ECO:0000269|PubMed:10471399, ECO:0000269|PubMed:10556521}.		cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; L-ascorbic acid metabolic process [GO:0019852]; L-ascorbic acid transmembrane transport [GO:0015882]; positive regulation of dendrite extension [GO:1903861]; response to oxidative stress [GO:0006979]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]; cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; L-ascorbic acid metabolic process [GO:0019852]; L-ascorbic acid transmembrane transport [GO:0015882]; positive regulation of dendrite extension [GO:1903861]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19379732}; Multi-pass membrane protein {ECO:0000269|PubMed:19379732}.
Q9UGI0	reviewed	ZRAN1_HUMAN	Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1)	ZRANB1 TRABID	Homo sapiens (Human)	708	FUNCTION: Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (PubMed:22157957, PubMed:23827681, PubMed:25752573, PubMed:25752577). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (PubMed:18281465). Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (PubMed:18281465). Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (PubMed:33637724). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Required in the stress fiber dynamics and cell migration (PubMed:21834987). {ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22157957, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:33637724}.		cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; positive regulation of Wnt signaling pathway [GO:0030177]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]; protein K63-linked deubiquitination [GO:0070536]; regulation of cell morphogenesis [GO:0022604]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; positive regulation of Wnt signaling pathway [GO:0030177]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]; protein K63-linked deubiquitination [GO:0070536]; regulation of cell morphogenesis [GO:0022604]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:25752577}. Nucleus {ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:25752577}. Note=Enriched in punctate localization in the cytoplasm. {ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:25752577}.
Q9UGI6	reviewed	KCNN3_HUMAN	Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa 3) (SKCa3) (KCa2.3)	KCNN3 K3	Homo sapiens (Human)	731	FUNCTION: Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:31155282, PubMed:20562108). Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity). {ECO:0000250|UniProtKB:P70605, ECO:0000269|PubMed:20562108, ECO:0000269|PubMed:31155282}.	MISCELLANEOUS: [Isoform 3]: Do not produce functional channels, but selectively suppresses endogenous SK3 currents, in a dominant-negative fashion. This dominant inhibitory effect extends to other members of the SK subfamily. Widely distributed in human tissues and is present at 20-60% of SK3 in the brain. {ECO:0000305}.	potassium ion transmembrane transport [GO:0071805]	cytoplasm [GO:0005737]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; small conductance calcium-activated potassium channel activity [GO:0016286]	cytoplasm [GO:0005737]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; small conductance calcium-activated potassium channel activity [GO:0016286]; potassium ion transmembrane transport [GO:0071805]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9UGI8	reviewed	TES_HUMAN	Testin (TESS)	TES	Homo sapiens (Human)	421	FUNCTION: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. {ECO:0000269|PubMed:11420696, ECO:0000269|PubMed:12571287, ECO:0000269|PubMed:12695497}.		negative regulation of cell population proliferation [GO:0008285]	cell junction [GO:0030054]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cell junction [GO:0030054]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; negative regulation of cell population proliferation [GO:0008285]	SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.
Q9UGI9	reviewed	AAKG3_HUMAN	5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3)	PRKAG3 AMPKG3	Homo sapiens (Human)	489	FUNCTION: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism (PubMed:17878938). It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:17878938}.		cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; glycogen biosynthetic process [GO:0005978]; glycolytic process [GO:0006096]; intracellular signal transduction [GO:0035556]; response to muscle activity involved in regulation of muscle adaptation [GO:0014873]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]	AMP binding [GO:0016208]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; AMP binding [GO:0016208]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; glycogen biosynthetic process [GO:0005978]; glycolytic process [GO:0006096]; intracellular signal transduction [GO:0035556]; response to muscle activity involved in regulation of muscle adaptation [GO:0014873]	
Q9UGJ0	reviewed	AAKG2_HUMAN	5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p)	PRKAG2	Homo sapiens (Human)	569	FUNCTION: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. {ECO:0000269|PubMed:14722619}.		ATP biosynthetic process [GO:0006754]; cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; glycogen metabolic process [GO:0005977]; intracellular signal transduction [GO:0035556]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase activity [GO:0045860]; regulation of fatty acid metabolic process [GO:0019217]; regulation of fatty acid oxidation [GO:0046320]; regulation of glucose import [GO:0046324]; regulation of glycolytic process [GO:0006110]; sterol biosynthetic process [GO:0016126]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]	ADP binding [GO:0043531]; AMP binding [GO:0016208]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; phosphorylase kinase regulator activity [GO:0008607]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; ADP binding [GO:0043531]; AMP binding [GO:0016208]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; phosphorylase kinase regulator activity [GO:0008607]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; ATP biosynthetic process [GO:0006754]; cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; glycogen metabolic process [GO:0005977]; intracellular signal transduction [GO:0035556]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase activity [GO:0045860]; regulation of fatty acid metabolic process [GO:0019217]; regulation of fatty acid oxidation [GO:0046320]; regulation of glucose import [GO:0046324]; regulation of glycolytic process [GO:0006110]; sterol biosynthetic process [GO:0016126]	
Q9UGJ1	reviewed	GCP4_HUMAN	Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (Gamma-ring complex protein 76 kDa) (h76p) (hGrip76)	TUBGCP4 76P GCP4	Homo sapiens (Human)	667	FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.		cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; recycling endosome [GO:0055037]; spindle pole [GO:0000922]	gamma-tubulin binding [GO:0043015]; structural constituent of cytoskeleton [GO:0005200]	centrosome [GO:0005813]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; recycling endosome [GO:0055037]; spindle pole [GO:0000922]; gamma-tubulin binding [GO:0043015]; structural constituent of cytoskeleton [GO:0005200]; cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Q9UGK3	reviewed	STAP2_HUMAN	Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate)	STAP2 BKS	Homo sapiens (Human)	403	FUNCTION: Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. {ECO:0000269|PubMed:10980601}.	MISCELLANEOUS: [Isoform 2]: Alu insert from position 358 to 403. {ECO:0000305}.		cytosol [GO:0005829]; plasma membrane [GO:0005886]	signaling adaptor activity [GO:0035591]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; signaling adaptor activity [GO:0035591]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10980601}.
Q9UGK8	reviewed	SRGEF_HUMAN	Secretion-regulating guanine nucleotide exchange factor (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF) (Guanine nucleotide exchange factor-related protein)	SERGEF DELGEF GNEFR	Homo sapiens (Human)	458	FUNCTION: Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.		negative regulation of protein secretion [GO:0050709]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; guanyl-nucleotide exchange factor activity [GO:0005085]; negative regulation of protein secretion [GO:0050709]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10571079}. Nucleus {ECO:0000269|PubMed:10571079}.
Q9UGL1	reviewed	KDM5B_HUMAN	Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B)	KDM5B JARID1B PLU1 RBBP2H1	Homo sapiens (Human)	1544	FUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}.		branching involved in mammary gland duct morphogenesis [GO:0060444]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin remodeling [GO:0006338]; lens fiber cell differentiation [GO:0070306]; mammary duct terminal end bud growth [GO:0060763]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of gene expression [GO:0010628]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; post-embryonic development [GO:0009791]; regulation of DNA-templated transcription [GO:0006355]; regulation of estradiol secretion [GO:2000864]; response to fungicide [GO:0060992]; rhythmic process [GO:0048511]; single fertilization [GO:0007338]; uterus morphogenesis [GO:0061038]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; nucleic acid binding [GO:0003676]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; nucleic acid binding [GO:0003676]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin remodeling [GO:0006338]; lens fiber cell differentiation [GO:0070306]; mammary duct terminal end bud growth [GO:0060763]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of gene expression [GO:0010628]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; post-embryonic development [GO:0009791]; regulation of DNA-templated transcription [GO:0006355]; regulation of estradiol secretion [GO:2000864]; response to fungicide [GO:0060992]; rhythmic process [GO:0048511]; single fertilization [GO:0007338]; uterus morphogenesis [GO:0061038]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:10336460, ECO:0000269|PubMed:12237901}.
Q9UGL9	reviewed	CRCT1_HUMAN	Cysteine-rich C-terminal protein 1 (Protein NICE-1)	CRCT1 C1orf42 NICE1	Homo sapiens (Human)	99							
Q9UGM1	reviewed	ACHA9_HUMAN	Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9)	CHRNA9 NACHRA9	Homo sapiens (Human)	479	FUNCTION: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840). {ECO:0000269|PubMed:11021840, ECO:0000269|PubMed:11752216, ECO:0000269|PubMed:25282151, ECO:0000305}.	MISCELLANEOUS: The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist). {ECO:0000305|PubMed:11752216}.	detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; membrane depolarization [GO:0051899]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to auditory stimulus [GO:0010996]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; calcium channel activity [GO:0005262]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; calcium channel activity [GO:0005262]; transmembrane signaling receptor activity [GO:0004888]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; membrane depolarization [GO:0051899]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to auditory stimulus [GO:0010996]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:25282151}; Multi-pass membrane protein {ECO:0000305|PubMed:25282151}.
Q9UGM3	reviewed	DMBT1_HUMAN	Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein)	DMBT1 GP340	Homo sapiens (Human)	2413	FUNCTION: May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. {ECO:0000269|PubMed:10485905, ECO:0000269|PubMed:11007786, ECO:0000269|PubMed:11751412, ECO:0000269|PubMed:16796526, ECO:0000269|PubMed:17548659, ECO:0000269|PubMed:17709527, ECO:0000269|PubMed:19189310, ECO:0000269|PubMed:9288095}.		defense response [GO:0006952]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; protein transport [GO:0015031]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle membrane [GO:0030670]; zymogen granule membrane [GO:0042589]	calcium-dependent protein binding [GO:0048306]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle membrane [GO:0030670]; zymogen granule membrane [GO:0042589]; calcium-dependent protein binding [GO:0048306]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375]; defense response [GO:0006952]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Some isoforms may be membrane-bound. Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells. Formed in the ducts of von Ebner gland, and released into the fluid bathing the taste buds contained in the taste papillae (By similarity). {ECO:0000250}.
Q9UGM5	reviewed	FETUB_HUMAN	Fetuin-B (16G2) (Fetuin-like protein IRL685) (Gugu)	FETUB	Homo sapiens (Human)	382	FUNCTION: Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity). {ECO:0000250}.		binding of sperm to zona pellucida [GO:0007339]; negative regulation of endopeptidase activity [GO:0010951]; single fertilization [GO:0007338]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; metalloendopeptidase inhibitor activity [GO:0008191]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; metalloendopeptidase inhibitor activity [GO:0008191]; binding of sperm to zona pellucida [GO:0007339]; negative regulation of endopeptidase activity [GO:0010951]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q9UGM6	reviewed	SYWM_HUMAN	Tryptophan--tRNA ligase, mitochondrial (EC 6.1.1.2) ((Mt)TrpRS) (Tryptophanyl-tRNA synthetase) (TrpRS)	WARS2	Homo sapiens (Human)	360	FUNCTION: Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis. {ECO:0000305|PubMed:28650581}.		mitochondrial tryptophanyl-tRNA aminoacylation [GO:0070183]; positive regulation of angiogenesis [GO:0045766]; tRNA aminoacylation for protein translation [GO:0006418]; vasculogenesis [GO:0001570]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; tryptophan-tRNA ligase activity [GO:0004830]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; tryptophan-tRNA ligase activity [GO:0004830]; mitochondrial tryptophanyl-tRNA aminoacylation [GO:0070183]; positive regulation of angiogenesis [GO:0045766]; tRNA aminoacylation for protein translation [GO:0006418]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:28236339}.
Q9UGN4	reviewed	CLM8_HUMAN	CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a)	CD300A CMRF35H IGSF12 HSPC083	Homo sapiens (Human)	299	FUNCTION: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). {ECO:0000269|PubMed:10746781, ECO:0000269|PubMed:16339535, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:9701027}.		cell adhesion [GO:0007155]; immune system process [GO:0002376]; negative regulation of activation of Janus kinase activity [GO:1902569]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of eosinophil activation [GO:1902567]; negative regulation of eosinophil migration [GO:2000417]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034125]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of NK T cell activation [GO:0051134]; negative regulation of phagocytosis, engulfment [GO:0060101]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; regulation of T cell receptor signaling pathway [GO:0050856]	extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	phosphatidylethanolamine binding [GO:0008429]; phosphatidylserine binding [GO:0001786]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylserine binding [GO:0001786]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; cell adhesion [GO:0007155]; immune system process [GO:0002376]; negative regulation of activation of Janus kinase activity [GO:1902569]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of eosinophil activation [GO:1902567]; negative regulation of eosinophil migration [GO:2000417]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034125]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of NK T cell activation [GO:0051134]; negative regulation of phagocytosis, engulfment [GO:0060101]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; regulation of T cell receptor signaling pathway [GO:0050856]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9UGN5	reviewed	PARP2_HUMAN	Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-)	PARP2 ADPRT2 ADPRTL2	Homo sapiens (Human)	583	FUNCTION: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:25043379, PubMed:27471034, PubMed:30104678, PubMed:32028527, PubMed:32939087, PubMed:34486521, PubMed:34874266, PubMed:34108479). Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379, PubMed:30104678, PubMed:30321391). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:32939087). Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 (PubMed:25043379). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site (PubMed:28190768, PubMed:32028527, PubMed:34486521, PubMed:34874266, PubMed:34108479). PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:10364231, PubMed:32939087, PubMed:34108479). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP2 in order to limit the length of poly-ADP-ribose chains (PubMed:34732825, PubMed:34795260). Specifically mediates formation of branched poly-ADP-ribosylation (PubMed:30104678). Branched poly-ADP-ribose chains are specifically recognized by some factors, such as APLF (PubMed:30104678). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034, PubMed:29361132). {ECO:0000269|PubMed:10364231, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29361132, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30321391, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32939087, ECO:0000269|PubMed:34108479, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266}.		base-excision repair [GO:0006284]; decidualization [GO:0046697]; DNA ADP-ribosylation [GO:0030592]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; extrinsic apoptotic signaling pathway [GO:0097191]; hippocampal neuron apoptotic process [GO:0110088]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; protein auto-ADP-ribosylation [GO:0070213]; protein poly-ADP-ribosylation [GO:0070212]; response to oxygen-glucose deprivation [GO:0090649]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-serine ADP-ribosyltransferase activity [GO:0140805]; nucleosome binding [GO:0031491]; nucleotidyltransferase activity [GO:0016779]; poly-ADP-D-ribose binding [GO:0072572]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-serine ADP-ribosyltransferase activity [GO:0140805]; nucleosome binding [GO:0031491]; nucleotidyltransferase activity [GO:0016779]; poly-ADP-D-ribose binding [GO:0072572]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]; base-excision repair [GO:0006284]; decidualization [GO:0046697]; DNA ADP-ribosylation [GO:0030592]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; extrinsic apoptotic signaling pathway [GO:0097191]; hippocampal neuron apoptotic process [GO:0110088]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; protein auto-ADP-ribosylation [GO:0070213]; protein poly-ADP-ribosylation [GO:0070212]; response to oxygen-glucose deprivation [GO:0090649]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10364231, ECO:0000269|PubMed:26704974}. Chromosome {ECO:0000269|PubMed:26704974, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30321391, ECO:0000269|PubMed:32939087, ECO:0000269|PubMed:33141820, ECO:0000269|PubMed:35349716}. Note=Recruited to DNA damage sites in a PARP1-dependent process: recognizes and binds poly-ADP-ribose chains produced by PARP1 at DNA damage sites via its N-terminus, leading to its recruitment. {ECO:0000269|PubMed:26704974, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30321391, ECO:0000269|PubMed:32939087, ECO:0000269|PubMed:33141820, ECO:0000269|PubMed:35349716}.
Q9UGP4	reviewed	LIMD1_HUMAN	LIM domain-containing protein 1	LIMD1	Homo sapiens (Human)	676	FUNCTION: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.		cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0035331]; negative regulation of osteoblast differentiation [GO:0045668]; osteoblast development [GO:0002076]; P-body assembly [GO:0033962]; phosphorylation [GO:0016310]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; regulation of cell shape [GO:0008360]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; RISC complex [GO:0016442]; transcription regulator complex [GO:0005667]	metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; RISC complex [GO:0016442]; transcription regulator complex [GO:0005667]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0035331]; negative regulation of osteoblast differentiation [GO:0045668]; osteoblast development [GO:0002076]; P-body assembly [GO:0033962]; phosphorylation [GO:0016310]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; regulation of cell shape [GO:0008360]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction, focal adhesion. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions. Down-regulation and/or elimination of its expression from the nucleus of neoplastic cells correlates strongly with poor patient prognosis and aggressive forms of breast carcinoma. Conversely, strong nuclear localization correlates with low-tumor grade and better patient prognosis.
Q9UGP5	reviewed	DPOLL_HUMAN	DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa)	POLL	Homo sapiens (Human)	575	FUNCTION: DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195). {ECO:0000269|PubMed:10887191, ECO:0000269|PubMed:10982892, ECO:0000269|PubMed:11457865, ECO:0000269|PubMed:12809503, ECO:0000269|PubMed:14627824, ECO:0000269|PubMed:15537631, ECO:0000269|PubMed:19806195, ECO:0000269|PubMed:20693240, ECO:0000269|PubMed:30250067}.		base-excision repair, gap-filling [GO:0006287]; DNA biosynthetic process [GO:0071897]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; nucleotide-excision repair [GO:0006289]; somatic hypermutation of immunoglobulin genes [GO:0016446]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; base-excision repair, gap-filling [GO:0006287]; DNA biosynthetic process [GO:0071897]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; nucleotide-excision repair [GO:0006289]; somatic hypermutation of immunoglobulin genes [GO:0016446]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10887191}. Chromosome {ECO:0000269|PubMed:30250067}. Note=Accumulates at sites of DNA damage. {ECO:0000269|PubMed:30250067}.
Q9UGP8	reviewed	SEC63_HUMAN	Translocation protein SEC63 homolog	SEC63 SEC63L	Homo sapiens (Human)	760	FUNCTION: Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}.		liver development [GO:0001889]; nitrogen compound metabolic process [GO:0006807]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]; protein targeting to membrane [GO:0006612]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; Sec62/Sec63 complex [GO:0031207]	protein transmembrane transporter activity [GO:0008320]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; Sec62/Sec63 complex [GO:0031207]; protein transmembrane transporter activity [GO:0008320]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; liver development [GO:0001889]; nitrogen compound metabolic process [GO:0006807]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]; protein targeting to membrane [GO:0006612]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Q9UGQ3	reviewed	GTR6_HUMAN	Solute carrier family 2, facilitated glucose transporter member 6 (Glucose transporter type 6) (GLUT-6)	SLC2A6 GLUT6	Homo sapiens (Human)	507	FUNCTION: Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose (PubMed:30431159). {ECO:0000269|PubMed:30431159, ECO:0000305|PubMed:30431159}.		dehydroascorbic acid transport [GO:0070837]; fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; regulation of glycolytic process [GO:0006110]; transmembrane transport [GO:0055085]	lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; fructose transmembrane transporter activity [GO:0005353]; glucose transmembrane transporter activity [GO:0005355]; transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; fructose transmembrane transporter activity [GO:0005353]; glucose transmembrane transporter activity [GO:0005355]; transmembrane transporter activity [GO:0022857]; dehydroascorbic acid transport [GO:0070837]; fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; regulation of glycolytic process [GO:0006110]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:30431159}; Multi-pass membrane protein {ECO:0000255}.
Q9UGR2	reviewed	Z3H7B_HUMAN	Zinc finger CCCH domain-containing protein 7B (Rotavirus 'X'-associated non-structural protein) (RoXaN)	ZC3H7B KIAA1031	Homo sapiens (Human)	977	FUNCTION: May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop. {ECO:0000269|PubMed:28431233}.		miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608]	nucleus [GO:0005634]	metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18799579}. Note=Nuclear localization seems to be depleted upon rotavirus A infection.
Q9UGT4	reviewed	SUSD2_HUMAN	Sushi domain-containing protein 2	SUSD2	Homo sapiens (Human)	822	FUNCTION: May be a cytokine receptor for GPR15LG. May be a tumor suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994). {ECO:0000269|PubMed:23131994, ECO:0000269|PubMed:25351403}.		negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell division [GO:0051782]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]		extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell division [GO:0051782]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23131994, ECO:0000269|PubMed:25351403}; Single-pass type I membrane protein {ECO:0000305}. Note=SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells. {ECO:0000269|PubMed:23131994}.
Q9UGU0	reviewed	TCF20_HUMAN	Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein)	TCF20 KIAA0292 SPBP	Homo sapiens (Human)	1960	FUNCTION: Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10995766}.
Q9UGU5	reviewed	HMGX4_HUMAN	HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG)	HMGXB4 HMG2L1 HMGBCG	Homo sapiens (Human)	601	FUNCTION: Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}.		endosome to lysosome transport [GO:0008333]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055]	NURF complex [GO:0016589]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]	NURF complex [GO:0016589]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; endosome to lysosome transport [GO:0008333]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Q9UGY1	reviewed	NOL12_HUMAN	Nucleolar protein 12	NOL12	Homo sapiens (Human)	213	FUNCTION: May bind to 28S rRNA. {ECO:0000250}.			nucleolus [GO:0005730]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; single-stranded DNA binding [GO:0003697]	nucleolus [GO:0005730]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; single-stranded DNA binding [GO:0003697]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
Q9UH03	reviewed	SEPT3_HUMAN	Neuronal-specific septin-3	SEPTIN3 SEP3 SEPT3	Homo sapiens (Human)	358	FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). {ECO:0000250, ECO:0000305}.		cytoskeleton-dependent cytokinesis [GO:0061640]	cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; presynapse [GO:0098793]; presynaptic cytoskeleton [GO:0099569]; septin complex [GO:0031105]; septin ring [GO:0005940]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]	cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; presynapse [GO:0098793]; presynaptic cytoskeleton [GO:0099569]; septin complex [GO:0031105]; septin ring [GO:0005940]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; cytoskeleton-dependent cytokinesis [GO:0061640]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Synapse {ECO:0000250}.
Q9UH17	reviewed	ABC3B_HUMAN	DNA dC->dU-editing enzyme APOBEC-3B (A3B) (EC 3.5.4.38) (Phorbolin-1-related protein) (Phorbolin-2/3)	APOBEC3B	Homo sapiens (Human)	382	FUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:15466872, ECO:0000269|PubMed:16060832, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:22457529}.	MISCELLANEOUS: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.; MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site. {ECO:0000305}.	clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; retrotransposon silencing [GO:0010526]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]	cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; DNA demethylation [GO:0080111]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; retrotransposon silencing [GO:0010526]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16699599, ECO:0000269|PubMed:18667511, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22915799}.
Q9UH65	reviewed	SWP70_HUMAN	Switch-associated protein 70 (SWAP-70)	SWAP70 KIAA0640 HSPC321	Homo sapiens (Human)	585	FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250, ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}.		actin filament bundle assembly [GO:0051017]; isotype switching [GO:0045190]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; negative regulation of peptidyl-serine dephosphorylation [GO:1902309]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of mast cell chemotaxis [GO:0060754]; regulation of protein localization [GO:0032880]; regulation of small GTPase mediated signal transduction [GO:0051056]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]; actin filament bundle assembly [GO:0051017]; isotype switching [GO:0045190]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; negative regulation of peptidyl-serine dephosphorylation [GO:1902309]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of mast cell chemotaxis [GO:0060754]; regulation of protein localization [GO:0032880]; regulation of small GTPase mediated signal transduction [GO:0051056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10681448}. Cell membrane. Nucleus {ECO:0000269|PubMed:10681448}. Cell projection, lamellipodium {ECO:0000269|PubMed:12925760}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12925760}. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448). In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760). {ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}.
Q9UH73	reviewed	COE1_HUMAN	Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor)	EBF1 COE1 EBF	Homo sapiens (Human)	591	FUNCTION: Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity). {ECO:0000250|UniProtKB:Q07802, ECO:0000269|PubMed:27807034}.; FUNCTION: (Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells (PubMed:28968461). In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency (PubMed:26819314). {ECO:0000269|PubMed:26819314, ECO:0000269|PubMed:28968461}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UH77	reviewed	KLHL3_HUMAN	Kelch-like protein 3	KLHL3 KIAA1129	Homo sapiens (Human)	587	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031, PubMed:25313067, PubMed:35093948). The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney, thereby regulating NaCl reabsorption (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031, PubMed:25313067, PubMed:35093948). The BCR(KLHL3) complex also mediates ubiquitination and degradation of WNK3 (PubMed:35179207). The BCR(KLHL3) complex also mediates ubiquitination of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney, leading to its degradation (By similarity). {ECO:0000250|UniProtKB:E0CZ16, ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:22406640, ECO:0000269|PubMed:23387299, ECO:0000269|PubMed:23453970, ECO:0000269|PubMed:23576762, ECO:0000269|PubMed:23665031, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:35093948}.		distal tubule morphogenesis [GO:0072156]; gene expression [GO:0010467]; monoatomic ion homeostasis [GO:0050801]; potassium ion homeostasis [GO:0055075]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; renal sodium ion absorption [GO:0070294]; selective autophagy [GO:0061912]; ubiquitin-dependent protein catabolic process [GO:0006511]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]	actin binding [GO:0003779]; cullin family protein binding [GO:0097602]; structural molecule activity [GO:0005198]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; actin binding [GO:0003779]; cullin family protein binding [GO:0097602]; structural molecule activity [GO:0005198]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; distal tubule morphogenesis [GO:0072156]; gene expression [GO:0010467]; monoatomic ion homeostasis [GO:0050801]; potassium ion homeostasis [GO:0055075]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; renal sodium ion absorption [GO:0070294]; selective autophagy [GO:0061912]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22406640}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22406640}.
Q9UH92	reviewed	MLX_HUMAN	Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4)	MLX BHLHD13 TCFL4	Homo sapiens (Human)	298	FUNCTION: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: [Isoform Alpha]: Cytoplasm {ECO:0000269|PubMed:10918583}. Note=Found predominantly in the cytoplasm (PubMed:10918583). {ECO:0000269|PubMed:10918583}.; SUBCELLULAR LOCATION: [Isoform Beta]: Cytoplasm {ECO:0000269|PubMed:10918583}. Note=Found predominantly in the cytoplasm (PubMed:10918583). {ECO:0000269|PubMed:10918583}.; SUBCELLULAR LOCATION: [Isoform Gamma]: Nucleus {ECO:0000269|PubMed:10918583}. Note=Found predominantly in the nucleus (PubMed:10918583). {ECO:0000269|PubMed:10918583}.
Q9UH99	reviewed	SUN2_HUMAN	SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2)	SUN2 FRIGG KIAA0668 RAB5IP UNC84B	Homo sapiens (Human)	717	FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}.		centrosome localization [GO:0051642]; meiotic cell cycle [GO:0051321]; mitotic spindle organization [GO:0007052]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nuclear migration [GO:0007097]; nuclear migration along microfilament [GO:0031022]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; positive regulation of cell migration [GO:0030335]	chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; endosome membrane [GO:0010008]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]	cytoskeleton-nuclear membrane anchor activity [GO:0140444]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; microtubule binding [GO:0008017]; protein-membrane adaptor activity [GO:0043495]	chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; endosome membrane [GO:0010008]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; cytoskeleton-nuclear membrane anchor activity [GO:0140444]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; microtubule binding [GO:0008017]; protein-membrane adaptor activity [GO:0043495]; centrosome localization [GO:0051642]; meiotic cell cycle [GO:0051321]; mitotic spindle organization [GO:0007052]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nuclear migration [GO:0007097]; nuclear migration along microfilament [GO:0031022]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; positive regulation of cell migration [GO:0030335]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:15082709}; Single-pass type II membrane protein {ECO:0000269|PubMed:15082709}. Nucleus envelope {ECO:0000269|PubMed:15082709, ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:17724119}. Endosome membrane {ECO:0000269|PubMed:10818110}; Single-pass type II membrane protein {ECO:0000305}.
Q9UHA4	reviewed	LTOR3_HUMAN	Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1)	LAMTOR3 MAP2K1IP1 MAPKSP1 PRO2783	Homo sapiens (Human)	124	FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:30181260, PubMed:29107538, PubMed:29123114, PubMed:29158492, PubMed:28935770). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:30181260, PubMed:29107538, PubMed:29123114, PubMed:29158492, PubMed:28935770). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:30181260, PubMed:29107538, PubMed:29123114, PubMed:29158492, PubMed:28935770). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity). {ECO:0000250|UniProtKB:O88653, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:30181260}.		cellular response to amino acid stimulus [GO:0071230]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; protein localization to cell junction [GO:1902414]; TORC1 signaling [GO:0038202]	endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; FNIP-folliculin RagC/D GAP [GO:1990877]; focal adhesion [GO:0005925]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; Ragulator complex [GO:0071986]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	kinase activator activity [GO:0019209]	endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; FNIP-folliculin RagC/D GAP [GO:1990877]; focal adhesion [GO:0005925]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; Ragulator complex [GO:0071986]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; kinase activator activity [GO:0019209]; cellular response to amino acid stimulus [GO:0071230]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; protein localization to cell junction [GO:1902414]; TORC1 signaling [GO:0038202]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:O88653}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88653}; Cytoplasmic side {ECO:0000250|UniProtKB:O88653}. Note=Recruited to lysosome and endosome membranes by LAMTOR1. {ECO:0000250|UniProtKB:O88653}.
Q9UHA7	reviewed	IL36A_HUMAN	Interleukin-36 alpha (FIL1 epsilon) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 6) (IL-1F6)	IL36A FIL1E IL1E IL1F6	Homo sapiens (Human)	158	FUNCTION: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes up-regulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by up-regulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in pro-inflammatory effects in the lung. {ECO:0000269|PubMed:14734551, ECO:0000269|PubMed:21881584, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:24829417}.	MISCELLANEOUS: Initial experiments using non-processed full-length protein found in vitro activity only in the ug range. {ECO:0000269|PubMed:14734551}.	cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-6 production [GO:0032755]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-6 production [GO:0032755]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:32272059}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}.
Q9UHB4	reviewed	NDOR1_HUMAN	NADPH-dependent diflavin oxidoreductase 1 (EC 1.18.1.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) (Novel reductase 1)	NDOR1 NR1	Homo sapiens (Human)	597	FUNCTION: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (PubMed:10625700, PubMed:28648056, PubMed:23596212, PubMed:20802492, PubMed:15900210). Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery (PubMed:28648056, PubMed:23596212, PubMed:20802492). In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins (PubMed:23596212, PubMed:20802492). It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (PubMed:28648056). In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (PubMed:12871938). {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:10625700, ECO:0000269|PubMed:12871938, ECO:0000269|PubMed:15900210, ECO:0000269|PubMed:20802492, ECO:0000269|PubMed:23596212, ECO:0000269|PubMed:28648056}.		electron transport chain [GO:0022900]; iron-sulfur cluster assembly [GO:0016226]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP binding [GO:0050661]; NADPH binding [GO:0070402]; NADPH-hemoprotein reductase activity [GO:0003958]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [GO:0016731]; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [GO:0016653]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP binding [GO:0050661]; NADPH binding [GO:0070402]; NADPH-hemoprotein reductase activity [GO:0003958]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [GO:0016731]; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [GO:0016653]; electron transport chain [GO:0022900]; iron-sulfur cluster assembly [GO:0016226]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:10625700, ECO:0000269|PubMed:12871939}. Note=Concentrated in perinuclear structure. {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:12871939}.
Q9UHB6	reviewed	LIMA1_HUMAN	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)	LIMA1 EPLIN SREBP3 PP624	Homo sapiens (Human)	759	FUNCTION: Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430}.	MISCELLANEOUS: [Isoform Beta]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform Alpha]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform Beta. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing. {ECO:0000305}.	actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; intestinal cholesterol absorption [GO:0030299]; negative regulation of actin filament depolymerization [GO:0030835]; ruffle organization [GO:0031529]	actin cytoskeleton [GO:0015629]; brush border membrane [GO:0031526]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; stress fiber [GO:0001725]	actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]	actin cytoskeleton [GO:0015629]; brush border membrane [GO:0031526]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; stress fiber [GO:0001725]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; intestinal cholesterol absorption [GO:0030299]; negative regulation of actin filament depolymerization [GO:0030835]; ruffle organization [GO:0031529]	SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion {ECO:0000269|PubMed:10618726, ECO:0000269|PubMed:24694988}. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:10618726}. Cell membrane {ECO:0000250|UniProtKB:Q9ERG0}. Note=Expressed in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (PubMed:29880681). Colocalizes with PXN at focal adhesions in mesangial cells (PubMed:24694988). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:24694988, ECO:0000269|PubMed:29880681}.
Q9UHB7	reviewed	AFF4_HUMAN	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)	AFF4 AF5Q31 MCEF HSPC092	Homo sapiens (Human)	1163	FUNCTION: Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.		regulation of gene expression [GO:0010468]; response to endoplasmic reticulum stress [GO:0034976]; spermatid development [GO:0007286]	euchromatin [GO:0000791]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023]		euchromatin [GO:0000791]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023]; regulation of gene expression [GO:0010468]; response to endoplasmic reticulum stress [GO:0034976]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12065898}. Note=Associates to transcriptionally active chromatin but not at snRNA genes. {ECO:0000250}.
Q9UHB9	reviewed	SRP68_HUMAN	Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein)	SRP68	Homo sapiens (Human)	627	FUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (PubMed:16672232, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38687, ECO:0000269|PubMed:16672232, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}.		response to xenobiotic stimulus [GO:0009410]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; ribosome [GO:0005840]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]	7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; ribosome [GO:0005840]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]; response to xenobiotic stimulus [GO:0009410]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10618370}. Nucleus, nucleolus {ECO:0000269|PubMed:10618370}. Endoplasmic reticulum {ECO:0000269|PubMed:28369529}.
Q9UHC1	reviewed	MLH3_HUMAN	DNA mismatch repair protein Mlh3 (MutL protein homolog 3)	MLH3	Homo sapiens (Human)	1453	FUNCTION: Probably involved in the repair of mismatches in DNA.		female meiosis I [GO:0007144]; male meiotic nuclear division [GO:0007140]; mismatch repair [GO:0006298]; protein localization [GO:0008104]; reciprocal meiotic recombination [GO:0007131]; synaptonemal complex assembly [GO:0007130]	chiasma [GO:0005712]; male germ cell nucleus [GO:0001673]; mismatch repair complex [GO:0032300]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; mismatched DNA binding [GO:0030983]; satellite DNA binding [GO:0003696]	chiasma [GO:0005712]; male germ cell nucleus [GO:0001673]; mismatch repair complex [GO:0032300]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; mismatched DNA binding [GO:0030983]; satellite DNA binding [GO:0003696]; female meiosis I [GO:0007144]; male meiotic nuclear division [GO:0007140]; mismatch repair [GO:0006298]; protein localization [GO:0008104]; reciprocal meiotic recombination [GO:0007131]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UHC3	reviewed	ASIC3_HUMAN	Acid-sensing ion channel 3 (ASIC3) (hASIC3) (Amiloride-sensitive cation channel 3) (Neuronal amiloride-sensitive cation channel 3) (Testis sodium channel 1) (hTNaC1)	ASIC3 ACCN3 SLNAC1 TNAC1	Homo sapiens (Human)	531	FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. {ECO:0000269|PubMed:9744806, ECO:0000269|PubMed:9886053}.	MISCELLANEOUS: Potentiated by FMRFamide-related neuropeptides. Sensitized and potentiated by NPSF. Regulated by lactate and Ca(2+). Inhibited by anti-inflammatory drugs, like salicylic acid (By similarity). Sensitized and potentiated by NPFF. {ECO:0000250}.	detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; response to acidic pH [GO:0010447]; response to heat [GO:0009408]; sensory perception [GO:0007600]; sensory perception of sour taste [GO:0050915]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]	perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	acid-sensing ion channel activity [GO:0044736]; enterobactin transmembrane transporter activity [GO:0042931]; monoatomic cation channel activity [GO:0005261]; sodium channel activity [GO:0005272]	perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; acid-sensing ion channel activity [GO:0044736]; enterobactin transmembrane transporter activity [GO:0042931]; monoatomic cation channel activity [GO:0005261]; sodium channel activity [GO:0005272]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; response to acidic pH [GO:0010447]; response to heat [GO:0009408]; sensory perception [GO:0007600]; sensory perception of sour taste [GO:0050915]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). {ECO:0000250}.
Q9UHC6	reviewed	CNTP2_HUMAN	Contactin-associated protein-like 2 (Cell recognition molecule Caspr2)	CNTNAP2 CASPR2 KIAA0868	Homo sapiens (Human)	1331	FUNCTION: Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. {ECO:0000250|UniProtKB:Q9CPW0, ECO:0000305|PubMed:33238150}.		adult behavior [GO:0030534]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; clustering of voltage-gated potassium channels [GO:0045163]; learning [GO:0007612]; limbic system development [GO:0021761]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; neuron recognition [GO:0008038]; positive regulation of gap junction assembly [GO:1903598]; prepulse inhibition [GO:0060134]; protein localization to juxtaparanode region of axon [GO:0071205]; social behavior [GO:0035176]; striatum development [GO:0021756]; superior temporal gyrus development [GO:0071109]; thalamus development [GO:0021794]; transmission of nerve impulse [GO:0019226]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]	axolemma [GO:0030673]; axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; synaptic membrane [GO:0097060]; voltage-gated potassium channel complex [GO:0008076]	enzyme binding [GO:0019899]; protease binding [GO:0002020]; transmembrane transporter binding [GO:0044325]	axolemma [GO:0030673]; axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; synaptic membrane [GO:0097060]; voltage-gated potassium channel complex [GO:0008076]; enzyme binding [GO:0019899]; protease binding [GO:0002020]; transmembrane transporter binding [GO:0044325]; adult behavior [GO:0030534]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; clustering of voltage-gated potassium channels [GO:0045163]; learning [GO:0007612]; limbic system development [GO:0021761]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; neuron recognition [GO:0008038]; positive regulation of gap junction assembly [GO:1903598]; prepulse inhibition [GO:0060134]; protein localization to juxtaparanode region of axon [GO:0071205]; social behavior [GO:0035176]; striatum development [GO:0021756]; superior temporal gyrus development [GO:0071109]; thalamus development [GO:0021794]; transmission of nerve impulse [GO:0019226]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9CPW0}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q9CPW0}. Cell junction, paranodal septate junction {ECO:0000250|UniProtKB:Q9CPW0}. Note=Expressed in the juxtaparadonal region. {ECO:0000250|UniProtKB:Q9CPW0}.
Q9UHC7	reviewed	MKRN1_HUMAN	E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1)	MKRN1 RNF61	Homo sapiens (Human)	482	FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269|PubMed:16785614, ECO:0000269|PubMed:19536131}.		protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]	
Q9UHC9	reviewed	NPCL1_HUMAN	NPC1-like intracellular cholesterol transporter 1 (NPC1L1) (Niemann-Pick C1-like protein 1)	NPC1L1	Homo sapiens (Human)	1359	FUNCTION: Plays a major role in cholesterol homeostasis (PubMed:22095670). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:22095670). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (By similarity). Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia (PubMed:15928087). May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (PubMed:15671032). May be involved in caveolin trafficking from the plasma membrane (By similarity). In addition, acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (PubMed:22095670). {ECO:0000250|UniProtKB:Q6T3U3, ECO:0000250|UniProtKB:Q6T3U4, ECO:0000269|PubMed:15928087, ECO:0000269|PubMed:22095670, ECO:0000305|PubMed:15671032}.	MISCELLANEOUS: Target of cholesterol lowering drugs. {ECO:0000269|PubMed:21525977}.	cellular response to sterol depletion [GO:0071501]; cholesterol biosynthetic process [GO:0006695]; cholesterol homeostasis [GO:0042632]; cholesterol transport [GO:0030301]; intestinal cholesterol absorption [GO:0030299]; lipoprotein metabolic process [GO:0042157]; vitamin E metabolic process [GO:0042360]; vitamin transport [GO:0051180]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; myosin V binding [GO:0031489]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; vitamin E binding [GO:0008431]	apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; myosin V binding [GO:0031489]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; vitamin E binding [GO:0008431]; cellular response to sterol depletion [GO:0071501]; cholesterol biosynthetic process [GO:0006695]; cholesterol homeostasis [GO:0042632]; cholesterol transport [GO:0030301]; intestinal cholesterol absorption [GO:0030299]; lipoprotein metabolic process [GO:0042157]; vitamin E metabolic process [GO:0042360]; vitamin transport [GO:0051180]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:15671032}; Multi-pass membrane protein {ECO:0000269|PubMed:15671032}. Cell membrane {ECO:0000250|UniProtKB:Q6T3U3}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:15671032}; Multi-pass membrane protein {ECO:0000269|PubMed:15671032}. Note=Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5. {ECO:0000250}.
Q9UHD0	reviewed	IL19_HUMAN	Interleukin-19 (IL-19) (Melanoma differentiation-associated protein-like protein) (NG.1)	IL19 ZMDA1	Homo sapiens (Human)	177	FUNCTION: Cytokine that functions as an anti-inflammatory and proangiogenic factor (PubMed:34932373). Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13 (PubMed:16365913). Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB (PubMed:12351624). In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 (PubMed:11564763). {ECO:0000250|UniProtKB:Q8CJ70, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:16365913, ECO:0000269|PubMed:34932373}.		apoptotic process [GO:0006915]; immune response [GO:0006955]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; reactive oxygen species metabolic process [GO:0072593]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; apoptotic process [GO:0006915]; immune response [GO:0006955]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; reactive oxygen species metabolic process [GO:0072593]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
Q9UHD1	reviewed	CHRD1_HUMAN	Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana)	CHORDC1 CHP1	Homo sapiens (Human)	332	FUNCTION: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). {ECO:0000269|PubMed:20230755, ECO:0000269|PubMed:32053105}.		centrosome duplication [GO:0051298]; chaperone-mediated protein folding [GO:0061077]; regulation of cellular response to heat [GO:1900034]; regulation of centrosome duplication [GO:0010824]		ADP binding [GO:0043531]; ATP binding [GO:0005524]; Hsp90 protein binding [GO:0051879]; zinc ion binding [GO:0008270]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; Hsp90 protein binding [GO:0051879]; zinc ion binding [GO:0008270]; centrosome duplication [GO:0051298]; chaperone-mediated protein folding [GO:0061077]; regulation of cellular response to heat [GO:1900034]; regulation of centrosome duplication [GO:0010824]	
Q9UHD2	reviewed	TBK1_HUMAN	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)	TBK1 NAK	Homo sapiens (Human)	729	FUNCTION: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:10581243, PubMed:11839743, PubMed:15485837, PubMed:21138416, PubMed:25636800, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:26611359, PubMed:32404352). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32972995}.	MISCELLANEOUS: In cancer cells, pathological TBK1 activation promotes oncogenic transformation by suppressing programmed cell death. Mechanistically, the RALB-SEC5/EXOC2-TBK1 signaling cascade seems to participate in both innate immune signaling and cell transformation. Additionally, TBK1 supports oncogenesis by directly phosphorylating and activating AKT1 at the exocyst (PubMed:21042276). {ECO:0000305|PubMed:21042276}.	activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; canonical NF-kappaB signal transduction [GO:0007249]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; dendritic cell proliferation [GO:0044565]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of TORC1 signaling [GO:1904262]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of macroautophagy [GO:0016239]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of xenophagy [GO:1904417]; protein phosphorylation [GO:0006468]; regulation of type I interferon production [GO:0032479]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; serine/threonine protein kinase complex [GO:1902554]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; serine/threonine protein kinase complex [GO:1902554]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; canonical NF-kappaB signal transduction [GO:0007249]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; dendritic cell proliferation [GO:0044565]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of TORC1 signaling [GO:1904262]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of macroautophagy [GO:0016239]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of xenophagy [GO:1904417]; protein phosphorylation [GO:0006468]; regulation of type I interferon production [GO:0032479]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:21813773, ECO:0000269|PubMed:29251827}. Note=Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2. {ECO:0000269|PubMed:17018283}.
Q9UHD4	reviewed	CIDEB_HUMAN	Lipid transferase CIDEB (Cell death activator CIDE-B) (Cell death-inducing DFFA-like effector B)	CIDEB	Homo sapiens (Human)	219	FUNCTION: Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:35939579). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:35939579). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes (By similarity). In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport (By similarity). Required for very-low-density lipoprotein (VLDL) lipidation and maturation (By similarity). Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles (By similarity). Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles (By similarity). May also activate apoptosis (PubMed:10619428). {ECO:0000250|UniProtKB:O70303, ECO:0000250|UniProtKB:P56198, ECO:0000269|PubMed:10619428, ECO:0000269|PubMed:35939579}.; FUNCTION: (Microbial infection) Involved in Hepatatis C virus (HCV) assembly and required for HCV entry into hepatocytes. {ECO:0000269|PubMed:27282740}.		activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; bile acid signaling pathway [GO:0038183]; COPII-coated vesicle cargo loading [GO:0090110]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lipid droplet fusion [GO:0160077]; lipid storage [GO:0019915]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; regulation of apoptotic process [GO:0042981]; regulation of triglyceride metabolic process [GO:0090207]; response to nutrient levels [GO:0031667]; very-low-density lipoprotein particle assembly [GO:0034379]	COPI-coated vesicle [GO:0030137]; COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; perinuclear region of cytoplasm [GO:0048471]	identical protein binding [GO:0042802]; lipid transfer activity [GO:0120013]; molecular adaptor activity [GO:0060090]; phosphatidic acid binding [GO:0070300]	COPI-coated vesicle [GO:0030137]; COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; perinuclear region of cytoplasm [GO:0048471]; identical protein binding [GO:0042802]; lipid transfer activity [GO:0120013]; molecular adaptor activity [GO:0060090]; phosphatidic acid binding [GO:0070300]; activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; bile acid signaling pathway [GO:0038183]; COPII-coated vesicle cargo loading [GO:0090110]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lipid droplet fusion [GO:0160077]; lipid storage [GO:0019915]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; regulation of apoptotic process [GO:0042981]; regulation of triglyceride metabolic process [GO:0090207]; response to nutrient levels [GO:0031667]; very-low-density lipoprotein particle assembly [GO:0034379]	SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:35939579}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O70303}; Peripheral membrane protein {ECO:0000250|UniProtKB:O70303}; Cytoplasmic side {ECO:0000250|UniProtKB:O70303}. Golgi apparatus {ECO:0000250|UniProtKB:O70303}. Cytoplasmic vesicle, COPI-coated vesicle {ECO:0000250|UniProtKB:O70303}. Note=Enriched at lipid droplet contact sites. {ECO:0000250|UniProtKB:O70303}.
Q9UHD8	reviewed	SEPT9_HUMAN	Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1)	SEPTIN9 KIAA0991 MSF SEPT9	Homo sapiens (Human)	586	FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}.		cytoskeleton-dependent cytokinesis [GO:0061640]; positive regulation of non-motile cilium assembly [GO:1902857]	actin cytoskeleton [GO:0015629]; axoneme [GO:0005930]; cell division site [GO:0032153]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; non-motile cilium [GO:0097730]; perinuclear region of cytoplasm [GO:0048471]; septin complex [GO:0031105]; septin ring [GO:0005940]; stress fiber [GO:0001725]	cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]	actin cytoskeleton [GO:0015629]; axoneme [GO:0005930]; cell division site [GO:0032153]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; non-motile cilium [GO:0097730]; perinuclear region of cytoplasm [GO:0048471]; septin complex [GO:0031105]; septin ring [GO:0005940]; stress fiber [GO:0001725]; cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]; cytoskeleton-dependent cytokinesis [GO:0061640]; positive regulation of non-motile cilium assembly [GO:1902857]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17546647, ECO:0000269|PubMed:17922164}. Note=In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes partly with actin stress fibers. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
Q9UHD9	reviewed	UBQL2_HUMAN	Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)	UBQLN2 N4BP4 PLIC2 HRIHFB2157	Homo sapiens (Human)	624	FUNCTION: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683). {ECO:0000269|PubMed:10983987, ECO:0000269|PubMed:18199683, ECO:0000269|PubMed:18307982, ECO:0000269|PubMed:19148225, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:24215460}.		autophagosome assembly [GO:0000045]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; negative regulation of G protein-coupled receptor internalization [GO:1904021]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; regulation of autophagosome assembly [GO:2000785]; regulation of macroautophagy [GO:0016241]; ubiquitin-dependent ERAD pathway [GO:0030433]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; molecular condensate scaffold activity [GO:0140693]; polyubiquitin modification-dependent protein binding [GO:0031593]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; molecular condensate scaffold activity [GO:0140693]; polyubiquitin modification-dependent protein binding [GO:0031593]; autophagosome assembly [GO:0000045]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; negative regulation of G protein-coupled receptor internalization [GO:1904021]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; regulation of autophagosome assembly [GO:2000785]; regulation of macroautophagy [GO:0016241]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18199683}. Nucleus {ECO:0000269|PubMed:9853615}. Membrane {ECO:0000250|UniProtKB:Q9QZM0}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:19148225}. Note=Colocalizes with a subset of proteasomes, namely those that are cytoskeleton associated or free in the cytosol. Associated with fibers in mitotic cells. {ECO:0000269|PubMed:10983987}.
Q9UHE5	reviewed	NAT8_HUMAN	N-acetyltransferase 8 (EC 2.3.1.-) (Acetyltransferase 2) (ATase2) (Camello-like protein 1) (Cysteinyl-conjugate N-acetyltransferase) (CCNAT) (EC 2.3.1.80)	NAT8 CML1 GLA TSC501	Homo sapiens (Human)	227	FUNCTION: Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). {ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:20392701, ECO:0000269|PubMed:24556617}.		amyloid fibril formation [GO:1990000]; glutathione metabolic process [GO:0006749]; peptidyl-lysine N6-acetylation [GO:0018003]; positive regulation of gene expression [GO:0010628]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]	cysteine-S-conjugate N-acetyltransferase activity [GO:0047198]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; N-acetyltransferase activity [GO:0008080]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; cysteine-S-conjugate N-acetyltransferase activity [GO:0047198]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; N-acetyltransferase activity [GO:0008080]; amyloid fibril formation [GO:1990000]; glutathione metabolic process [GO:0006749]; peptidyl-lysine N6-acetylation [GO:0018003]; positive regulation of gene expression [GO:0010628]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Q9UHE8	reviewed	STEA1_HUMAN	STEAP1 protein (Six-transmembrane epithelial antigen of prostate 1)	STEAP1 PRSS24 STEAP	Homo sapiens (Human)	339	FUNCTION: Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4. {ECO:0000269|PubMed:32409586}.		iron ion transmembrane transport [GO:0034755]	cell-cell junction [GO:0005911]; endosome [GO:0005768]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]	heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]	cell-cell junction [GO:0005911]; endosome [GO:0005768]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; iron ion transmembrane transport [GO:0034755]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q9CWR7}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:32409586}; Multi-pass membrane protein {ECO:0000255}.
Q9UHF0	reviewed	TKNK_HUMAN	Tachykinin-3 (ZNEUROK1) [Cleaved into: Neurokinin-B (NKB) (Neuromedin-K)]	TAC3 NKNB UNQ585/PRO1155	Homo sapiens (Human)	121	FUNCTION: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function. {ECO:0000250, ECO:0000269|PubMed:19079066}.		female pregnancy [GO:0007565]; neuropeptide signaling pathway [GO:0007218]; positive regulation of blood pressure [GO:0045777]; tachykinin receptor signaling pathway [GO:0007217]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; signaling receptor binding [GO:0005102]; female pregnancy [GO:0007565]; neuropeptide signaling pathway [GO:0007218]; positive regulation of blood pressure [GO:0045777]; tachykinin receptor signaling pathway [GO:0007217]	SUBCELLULAR LOCATION: Secreted.
Q9UHF1	reviewed	EGFL7_HUMAN	Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)	EGFL7 MEGF7 UNQ187/PRO1449	Homo sapiens (Human)	273	FUNCTION: Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis. {ECO:0000269|PubMed:23386126, ECO:0000269|PubMed:23639441}.	MISCELLANEOUS: Endothelial cells depleted in EGFL7 by siRNAs display dramatic alterations in adhesion, morphology, and sprouting. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization.	anatomical structure development [GO:0048856]; angiogenesis [GO:0001525]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; signaling receptor binding [GO:0005102]; anatomical structure development [GO:0048856]; angiogenesis [GO:0001525]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:23386126}.
Q9UHF3	reviewed	NAT8B_HUMAN	Putative N-acetyltransferase 8B (EC 2.3.1.-) (Acetyltransferase 1) (ATase1) (Camello-like protein 2)	NAT8B CML2	Homo sapiens (Human)	227	FUNCTION: Lysine N-acetyltransferase catalyzing peptidyl-lysine N6-acetylation of various proteins, including PROM1/CD133. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). Acetylates and stabilizes BACE1 immature protein, leading to increased steady-state levels in neurons. By acting on BACE1 expression, may regulate amyloid beta-peptide formation (PubMed:19011241). May play a role in regulation of gastrulation (By similarity). {ECO:0000250|UniProtKB:Q9JIY6, ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:24556617}.		amyloid fibril formation [GO:1990000]; amyloid-beta metabolic process [GO:0050435]; gastrulation with mouth forming second [GO:0001702]; negative regulation of apoptotic process [GO:0043066]; peptidyl-lysine N6-acetylation [GO:0018003]; positive regulation of gene expression [GO:0010628]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; N-acetyltransferase activity [GO:0008080]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; N-acetyltransferase activity [GO:0008080]; amyloid fibril formation [GO:1990000]; amyloid-beta metabolic process [GO:0050435]; gastrulation with mouth forming second [GO:0001702]; negative regulation of apoptotic process [GO:0043066]; peptidyl-lysine N6-acetylation [GO:0018003]; positive regulation of gene expression [GO:0010628]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:24556617}; Single-pass type II membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19011241}; Single-pass type II membrane protein {ECO:0000255}. Note=Enriched in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). {ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:24556617}.
Q9UHF4	reviewed	I20RA_HUMAN	Interleukin-20 receptor subunit alpha (IL-20 receptor subunit alpha) (IL-20R-alpha) (IL-20RA) (Cytokine receptor class-II member 8) (Cytokine receptor family 2 member 8) (CRF2-8) (IL-20R1) (ZcytoR7)	IL20RA UNQ681/PRO1315	Homo sapiens (Human)	553	FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.		cytokine-mediated signaling pathway [GO:0019221]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; regulation of bone resorption [GO:0045124]	plasma membrane [GO:0005886]	cytokine receptor activity [GO:0004896]; interleukin-20 binding [GO:0042015]	plasma membrane [GO:0005886]; cytokine receptor activity [GO:0004896]; interleukin-20 binding [GO:0042015]; cytokine-mediated signaling pathway [GO:0019221]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; regulation of bone resorption [GO:0045124]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9UHF7	reviewed	TRPS1_HUMAN	Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79)	TRPS1	Homo sapiens (Human)	1281	FUNCTION: Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of chondrocyte differentiation [GO:0032330]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein domain specific binding [GO:0019904]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein domain specific binding [GO:0019904]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of chondrocyte differentiation [GO:0032330]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12885770}.
Q9UHG0	reviewed	DCDC2_HUMAN	Doublecortin domain-containing protein 2 (Protein RU2S)	DCDC2 KIAA1154 RU2	Homo sapiens (Human)	476	FUNCTION: Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). {ECO:0000250|UniProtKB:D3ZR10, ECO:0000269|PubMed:25557784, ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}.		cellular defense response [GO:0006968]; cilium assembly [GO:0060271]; dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]	axoneme [GO:0005930]; centriolar satellite [GO:0034451]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinocilium [GO:0060091]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]	kinesin binding [GO:0019894]	axoneme [GO:0005930]; centriolar satellite [GO:0034451]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinocilium [GO:0060091]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; kinesin binding [GO:0019894]; cellular defense response [GO:0006968]; cilium assembly [GO:0060271]; dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:25557784, ECO:0000269|PubMed:27319779}. Cell projection, kinocilium {ECO:0000250|UniProtKB:D3ZR10}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:D3ZR10}. Note=Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner. {ECO:0000269|PubMed:25557784}.
Q9UHG2	reviewed	PCS1N_HUMAN	ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS) (N-proSAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))]	PCSK1N	Homo sapiens (Human)	260	FUNCTION: May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity). {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [Big LEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [PEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}.		neuropeptide signaling pathway [GO:0007218]; peptide hormone processing [GO:0016486]; response to cold [GO:0009409]; response to dietary excess [GO:0002021]	extracellular space [GO:0005615]; secretory granule [GO:0030141]; trans-Golgi network [GO:0005802]	endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]	extracellular space [GO:0005615]; secretory granule [GO:0030141]; trans-Golgi network [GO:0005802]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]; neuropeptide signaling pathway [GO:0007218]; peptide hormone processing [GO:0016486]; response to cold [GO:0009409]; response to dietary excess [GO:0002021]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9QXV0}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9QXV0}. Note=A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Guam disease). {ECO:0000269|PubMed:12914799, ECO:0000269|PubMed:14746899}.
Q9UHG3	reviewed	PCYOX_HUMAN	Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase)	PCYOX1 KIAA0908 PCL1 UNQ597/PRO1183	Homo sapiens (Human)	505	FUNCTION: Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (PubMed:10585463, PubMed:11078725, PubMed:12186880). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (PubMed:10585463). {ECO:0000250|UniProtKB:F1N2K1, ECO:0000269|PubMed:10585463, ECO:0000269|PubMed:11078725, ECO:0000269|PubMed:12186880}.		prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328]	extracellular exosome [GO:0070062]; lysosome [GO:0005764]; very-low-density lipoprotein particle [GO:0034361]	FAD binding [GO:0071949]; farnesylcysteine lyase activity [GO:0102149]; prenylcysteine oxidase activity [GO:0001735]	extracellular exosome [GO:0070062]; lysosome [GO:0005764]; very-low-density lipoprotein particle [GO:0034361]; FAD binding [GO:0071949]; farnesylcysteine lyase activity [GO:0102149]; prenylcysteine oxidase activity [GO:0001735]; prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:10585463}.
Q9UHH9	reviewed	IP6K2_HUMAN	Inositol hexakisphosphate kinase 2 (InsP6 kinase 2) (InsP6K2) (EC 2.7.4.-) (P(i)-uptake stimulator) (PiUS)	IP6K2 IHPK2 TCCCIA00113	Homo sapiens (Human)	426	FUNCTION: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). {ECO:0000269|PubMed:10574768, ECO:0000269|PubMed:30624931}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to flavonoid [GO:1905396]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; negative regulation of cell growth [GO:0030308]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein stabilization [GO:0050821]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; flavonoid binding [GO:0097243]; inositol 5-diphosphate pentakisphosphate 5-kinase activity [GO:0052836]; inositol diphosphate tetrakisphosphate kinase activity [GO:0052839]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; flavonoid binding [GO:0097243]; inositol 5-diphosphate pentakisphosphate 5-kinase activity [GO:0052836]; inositol diphosphate tetrakisphosphate kinase activity [GO:0052839]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]; cellular response to flavonoid [GO:1905396]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; negative regulation of cell growth [GO:0030308]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11502751}.
Q9UHI5	reviewed	LAT2_HUMAN	Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8)	SLC7A8 LAT2	Homo sapiens (Human)	535	FUNCTION: Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1. Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids (PubMed:10391915, PubMed:15918515, PubMed:11311135, PubMed:11847106, PubMed:12716892, PubMed:15081149, PubMed:29355479, PubMed:33298890, PubMed:34848541). Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter (PubMed:11847106). This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake (PubMed:11847106, PubMed:10391915). May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (PubMed:12716892). Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (By similarity). Mediates the uptake of L-DOPA (By similarity). May participate in auditory function (By similarity). {ECO:0000250|UniProtKB:Q9QXW9, ECO:0000250|UniProtKB:Q9WVR6, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11847106, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15081149, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15918515, ECO:0000269|PubMed:29355479, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541}.		amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine import across plasma membrane [GO:1904273]; L-leucine import across plasma membrane [GO:1903801]; leucine import across plasma membrane [GO:0098713]; leucine transport [GO:0015820]; neutral amino acid transport [GO:0015804]; proline transmembrane transport [GO:0035524]; thyroid hormone transport [GO:0070327]; transport across blood-brain barrier [GO:0150104]; tryptophan transport [GO:0015827]; valine transport [GO:0015829]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-amino acid transmembrane transporter activity [GO:0015179]; L-leucine transmembrane transporter activity [GO:0015190]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; organic cation transmembrane transporter activity [GO:0015101]; peptide antigen binding [GO:0042605]; protein heterodimerization activity [GO:0046982]; thyroid hormone transmembrane transporter activity [GO:0015349]; toxin transmembrane transporter activity [GO:0019534]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-amino acid transmembrane transporter activity [GO:0015179]; L-leucine transmembrane transporter activity [GO:0015190]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; organic cation transmembrane transporter activity [GO:0015101]; peptide antigen binding [GO:0042605]; protein heterodimerization activity [GO:0046982]; thyroid hormone transmembrane transporter activity [GO:0015349]; toxin transmembrane transporter activity [GO:0019534]; amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine import across plasma membrane [GO:1904273]; L-leucine import across plasma membrane [GO:1903801]; leucine import across plasma membrane [GO:0098713]; leucine transport [GO:0015820]; neutral amino acid transport [GO:0015804]; proline transmembrane transport [GO:0035524]; thyroid hormone transport [GO:0070327]; transport across blood-brain barrier [GO:0150104]; tryptophan transport [GO:0015827]; valine transport [GO:0015829]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29355479, ECO:0000269|PubMed:34848541}; Multi-pass membrane protein {ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541}. Basolateral cell membrane {ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:15918515}; Multi-pass membrane protein {ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541}. Note=Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi. {ECO:0000269|PubMed:10574970}.
Q9UHI6	reviewed	DDX20_HUMAN	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3)	DDX20 DP103 GEMIN3	Homo sapiens (Human)	824	FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}.		negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oogenesis [GO:0048477]; positive regulation of apoptotic process [GO:0043065]; regulation of steroid biosynthetic process [GO:0050810]; RNA processing [GO:0006396]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oogenesis [GO:0048477]; positive regulation of apoptotic process [GO:0043065]; regulation of steroid biosynthetic process [GO:0050810]; RNA processing [GO:0006396]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10601333, ECO:0000305|PubMed:12095920}. Nucleus, gem {ECO:0000269|PubMed:10601333, ECO:0000305|PubMed:10383418}. Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems). {ECO:0000269|PubMed:10601333}.
Q9UHI7	reviewed	S23A1_HUMAN	Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (hSVCT1) (Yolk sac permease-like molecule 3)	SLC23A1 SVCT1 YSPL3	Homo sapiens (Human)	598	FUNCTION: Sodium:ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10556483, PubMed:10556521, PubMed:10631088, PubMed:36749388). Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber (PubMed:36749388). {ECO:0000269|PubMed:10556483, ECO:0000269|PubMed:10556521, ECO:0000269|PubMed:10631088, ECO:0000269|PubMed:36749388}.; FUNCTION: [Isoform 2]: Inactive transporter. {ECO:0000269|PubMed:10556483}.	MISCELLANEOUS: Treatment with the protein kinase C stimulator PMA results in a 10-fold decrease in ascorbate accumulation in transfected cells. {ECO:0000269|PubMed:10556521}.	brain development [GO:0007420]; dehydroascorbic acid transport [GO:0070837]; L-ascorbic acid metabolic process [GO:0019852]; L-ascorbic acid transmembrane transport [GO:0015882]; lung development [GO:0030324]; nucleobase transport [GO:0015851]; response to toxic substance [GO:0009636]; sodium ion transport [GO:0006814]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]	dehydroascorbic acid transmembrane transporter activity [GO:0033300]; L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]; nucleobase transmembrane transporter activity [GO:0015205]; sodium ion transmembrane transporter activity [GO:0015081]; urate transmembrane transporter activity [GO:0015143]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]; nucleobase transmembrane transporter activity [GO:0015205]; sodium ion transmembrane transporter activity [GO:0015081]; urate transmembrane transporter activity [GO:0015143]; brain development [GO:0007420]; dehydroascorbic acid transport [GO:0070837]; L-ascorbic acid metabolic process [GO:0019852]; L-ascorbic acid transmembrane transport [GO:0015882]; lung development [GO:0030324]; nucleobase transport [GO:0015851]; response to toxic substance [GO:0009636]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10631088, ECO:0000269|PubMed:19379732, ECO:0000269|PubMed:36749388}; Multi-pass membrane protein {ECO:0000269|PubMed:19379732}.
Q9UHI8	reviewed	ATS1_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-) (METH-1)	ADAMTS1 KIAA1346 METH1	Homo sapiens (Human)	967	FUNCTION: Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. {ECO:0000250, ECO:0000269|PubMed:10438512}.		extracellular matrix organization [GO:0030198]; heart trabecula formation [GO:0060347]; integrin-mediated signaling pathway [GO:0007229]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; ovulation from ovarian follicle [GO:0001542]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteolysis [GO:0006508]	basement membrane [GO:0005604]; cytoplasmic vesicle [GO:0031410]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	basement membrane [GO:0005604]; cytoplasmic vesicle [GO:0031410]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; extracellular matrix organization [GO:0030198]; heart trabecula formation [GO:0060347]; integrin-mediated signaling pathway [GO:0007229]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; ovulation from ovarian follicle [GO:0001542]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q9UHJ3	reviewed	SMBT1_HUMAN	Scm-like with four MBT domains protein 1 (hSFMBT) (Renal ubiquitous protein 1)	SFMBT1 RU1	Homo sapiens (Human)	866	FUNCTION: Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis. {ECO:0000269|PubMed:17599839, ECO:0000269|PubMed:23349461, ECO:0000269|PubMed:23592795}.		cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of muscle organ development [GO:0048635]; spermatogenesis [GO:0007283]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; transcription corepressor activity [GO:0003714]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of muscle organ development [GO:0048635]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17599839}.
Q9UHJ6	reviewed	SHPK_HUMAN	Sedoheptulokinase (SHK) (EC 2.7.1.14) (Carbohydrate kinase-like protein)	SHPK CARKL	Homo sapiens (Human)	478	FUNCTION: Acts as a modulator of macrophage activation through control of glucose metabolism. {ECO:0000250}.		carbohydrate metabolic process [GO:0005975]; cellular response to interleukin-13 [GO:0035963]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; glycerol metabolic process [GO:0006071]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; phosphorylation [GO:0016310]; regulation of inflammatory response [GO:0050727]; regulation of macrophage activation [GO:0043030]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; sedoheptulokinase activity [GO:0050277]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; sedoheptulokinase activity [GO:0050277]; carbohydrate metabolic process [GO:0005975]; cellular response to interleukin-13 [GO:0035963]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; glycerol metabolic process [GO:0006071]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; phosphorylation [GO:0016310]; regulation of inflammatory response [GO:0050727]; regulation of macrophage activation [GO:0043030]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9UHJ9	reviewed	PGAP2_HUMAN	Post-GPI attachment to proteins factor 2 (FGF receptor-activating protein 1)	PGAP2 FRAG1	Homo sapiens (Human)	254	FUNCTION: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface. {ECO:0000269|PubMed:29374258}.	MISCELLANEOUS: [Isoform 1]: This isoform is predicted to contain an additional transmembrane domain at position 85-105. If this domain exists, the topology of the protein would be modified, possibly challenging the GPI-anchor remodeling function of the protein. {ECO:0000305}.	GPI anchor biosynthetic process [GO:0006506]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]		endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; GPI anchor biosynthetic process [GO:0006506]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9UHK0	reviewed	NUFP1_HUMAN	FMR1-interacting protein NUFIP1 (Nuclear FMR1-interacting protein 1) (Nuclear FMRP-interacting protein 1)	NUFIP1	Homo sapiens (Human)	495	FUNCTION: Binds RNA. {ECO:0000269|PubMed:10556305}.		box C/D snoRNP assembly [GO:0000492]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA processing [GO:0006396]	fibrillar center [GO:0001650]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; pre-snoRNP complex [GO:0070761]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991]; transcription elongation factor complex [GO:0008023]	ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]	fibrillar center [GO:0001650]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; pre-snoRNP complex [GO:0070761]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991]; transcription elongation factor complex [GO:0008023]; ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; box C/D snoRNP assembly [GO:0000492]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10556305}. Note=Distributed in the nucleus in a dot-like pattern.
Q9UHK6	reviewed	AMACR_HUMAN	Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase)	AMACR	Homo sapiens (Human)	382	FUNCTION: Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359). {ECO:0000269|PubMed:10655068, ECO:0000269|PubMed:11060359, ECO:0000269|PubMed:7649182}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Expression is elevated in prostate cancer. {ECO:0000305}.	bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]	alpha-methylacyl-CoA racemase activity [GO:0008111]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; alpha-methylacyl-CoA racemase activity [GO:0008111]; signaling receptor binding [GO:0005102]; bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:11060344, ECO:0000269|PubMed:11060359, ECO:0000269|PubMed:7649182}. Mitochondrion {ECO:0000269|PubMed:11060344, ECO:0000269|PubMed:11060359, ECO:0000269|PubMed:7649182}.
Q9UHL0	reviewed	DDX25_HUMAN	ATP-dependent RNA helicase DDX25 (EC 3.6.4.13) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase)	DDX25 GRTH	Homo sapiens (Human)	483	FUNCTION: ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity). {ECO:0000250, ECO:0000269|PubMed:10608860}.		mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of translation [GO:0006417]; spermatid development [GO:0007286]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of translation [GO:0006417]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10608860}. Nucleus {ECO:0000250|UniProtKB:Q9QY15}. Note=Detected in both cytoplasm and nucleus of testicular cells. Also detected in chromatoid bodies of round spermatids (By similarity). {ECO:0000250|UniProtKB:Q9QY15}.
Q9UHL4	reviewed	DPP2_HUMAN	Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase)	DPP7 DPP2 QPP	Homo sapiens (Human)	492	FUNCTION: Plays an important role in the degradation of some oligopeptides. {ECO:0000269|PubMed:15487984}.		lysosomal protein catabolic process [GO:1905146]; proteolysis [GO:0006508]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982]	aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236]	azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982]; aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236]; lysosomal protein catabolic process [GO:1905146]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:15487984}. Cytoplasmic vesicle {ECO:0000269|PubMed:15487984}. Secreted {ECO:0000269|PubMed:15487984}.
Q9UHL9	reviewed	GT2D1_HUMAN	General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein)	GTF2IRD1 CREAM1 GTF3 MUSTRD1 RBAP2 WBSCR11 WBSCR12	Homo sapiens (Human)	959	FUNCTION: May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11438732}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]; transition between slow and fast fiber [GO:0014886]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]; transition between slow and fast fiber [GO:0014886]	SUBCELLULAR LOCATION: Nucleus.
Q9UHM6	reviewed	OPN4_HUMAN	Melanopsin (Opsin-4)	OPN4 MOP	Homo sapiens (Human)	478	FUNCTION: Photoreceptor that binds cis-retinaldehydes (PubMed:15674244). Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light (By similarity). May be involved in the optokinetic visual tracking response (By similarity). May be involved in the regulation of retinal hyaloid vessel growth and regression (By similarity). {ECO:0000250|UniProtKB:Q9QXZ9, ECO:0000269|PubMed:15674244}.		cellular response to light stimulus [GO:0071482]; detection of temperature stimulus involved in thermoception [GO:0050960]; G protein-coupled receptor signaling pathway [GO:0007186]; hyaloid vascular plexus regression [GO:1990384]; optokinetic behavior [GO:0007634]; phototransduction [GO:0007602]; regulation of circadian rhythm [GO:0042752]; retina development in camera-type eye [GO:0060041]; rhythmic process [GO:0048511]; thermotaxis [GO:0043052]; visual perception [GO:0007601]	axon [GO:0030424]; dendrite [GO:0030425]; membrane [GO:0016020]; perikaryon [GO:0043204]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913]	11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020]	axon [GO:0030424]; dendrite [GO:0030425]; membrane [GO:0016020]; perikaryon [GO:0043204]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913]; 11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020]; cellular response to light stimulus [GO:0071482]; detection of temperature stimulus involved in thermoception [GO:0050960]; G protein-coupled receptor signaling pathway [GO:0007186]; hyaloid vascular plexus regression [GO:1990384]; optokinetic behavior [GO:0007634]; phototransduction [GO:0007602]; regulation of circadian rhythm [GO:0042752]; retina development in camera-type eye [GO:0060041]; rhythmic process [GO:0048511]; thermotaxis [GO:0043052]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9QXZ9}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QXZ9}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QXZ9}. Perikaryon {ECO:0000250|UniProtKB:Q9QXZ9}.
Q9UHN1	reviewed	DPOG2_HUMAN	DNA polymerase subunit gamma-2, mitochondrial (DNA polymerase gamma accessory 55 kDa subunit) (p55) (Mitochondrial DNA polymerase accessory subunit) (MtPolB) (PolG-beta)	POLG2 MTPOLB	Homo sapiens (Human)	485	FUNCTION: Mitochondrial polymerase processivity subunit. It regulates the polymerase and exonuclease activities promoting processive DNA synthesis. Binds to ss-DNA. {ECO:0000269|PubMed:30157269, ECO:0000269|PubMed:31778857}.		DNA-templated DNA replication [GO:0006261]; in utero embryonic development [GO:0001701]; mitochondrial DNA replication [GO:0006264]; mitochondrion morphogenesis [GO:0070584]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; respiratory electron transport chain [GO:0022904]	cytoplasm [GO:0005737]; gamma DNA polymerase complex [GO:0005760]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	DNA polymerase binding [GO:0070182]; DNA polymerase processivity factor activity [GO:0030337]; DNA-directed DNA polymerase activity [GO:0003887]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; gamma DNA polymerase complex [GO:0005760]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; DNA polymerase binding [GO:0070182]; DNA polymerase processivity factor activity [GO:0030337]; DNA-directed DNA polymerase activity [GO:0003887]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; DNA-templated DNA replication [GO:0006261]; in utero embryonic development [GO:0001701]; mitochondrial DNA replication [GO:0006264]; mitochondrion morphogenesis [GO:0070584]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; respiratory electron transport chain [GO:0022904]	SUBCELLULAR LOCATION: Mitochondrion.
Q9UHN6	reviewed	CEIP2_HUMAN	Inactive cell surface hyaluronidase CEMIP2 (Cell migration-inducing hyaluronidase 2) (Transmembrane protein 2)	CEMIP2 KIAA1412 TMEM2	Homo sapiens (Human)	1383	FUNCTION: Unlike its mouse ortholog has no catalytic hyaluronic acid-degrading activity, but acts as a regulator of hyaluronan (HA) metabolism through regulation of expression of CEMIP and HAS2, two enzymes involved in HA depolymerization and HA synthesis, respectively. {ECO:0000269|PubMed:37196767}.		angiogenesis [GO:0001525]; hyaluronan catabolic process [GO:0030214]; regulation of sprouting angiogenesis [GO:1903670]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; angiogenesis [GO:0001525]; hyaluronan catabolic process [GO:0030214]; regulation of sprouting angiogenesis [GO:1903670]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5FWI3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q5FWI3}.
Q9UHP3	reviewed	UBP25_HUMAN	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)	USP25 USP21	Homo sapiens (Human)	1055	FUNCTION: Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.; FUNCTION: The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.		negative regulation of ERAD pathway [GO:1904293]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	ATPase binding [GO:0051117]; cysteine-type deubiquitinase activity [GO:0004843]; peptidase activity [GO:0008233]; SUMO binding [GO:0032183]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein peptidase activity [GO:0019783]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; ATPase binding [GO:0051117]; cysteine-type deubiquitinase activity [GO:0004843]; peptidase activity [GO:0008233]; SUMO binding [GO:0032183]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein peptidase activity [GO:0019783]; negative regulation of ERAD pathway [GO:1904293]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16501887, ECO:0000269|PubMed:19440361}.; SUBCELLULAR LOCATION: [Isoform USP25m]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Some transient punctuate nuclear location in myotubes during myocyte development. {ECO:0000250}.
Q9UHP6	reviewed	RSP14_HUMAN	Radial spoke head 14 homolog (Rhabdoid tumor deletion region protein 1)	RSPH14 RTDR1	Homo sapiens (Human)	348	FUNCTION: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. {ECO:0000250|UniProtKB:Q9D3W1}.			cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9D3W1}.
Q9UHP7	reviewed	CLC2D_HUMAN	C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin)	CLEC2D CLAX LLT1 OCIL	Homo sapiens (Human)	191	FUNCTION: Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates the release of interferon-gamma (PubMed:15104121). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656). {ECO:0000269|PubMed:14753741, ECO:0000269|PubMed:15104121, ECO:0000269|PubMed:15123656, ECO:0000269|PubMed:16339513, ECO:0000269|PubMed:20843815}.		cell surface receptor signaling pathway [GO:0007166]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15104121, ECO:0000269|PubMed:20843815, ECO:0000305|PubMed:16339513}; Single-pass type II membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum {ECO:0000269|PubMed:20843815}.; SUBCELLULAR LOCATION: [Isoform 4]: Endoplasmic reticulum {ECO:0000269|PubMed:20843815}.
Q9UHQ1	reviewed	NARF_HUMAN	Nuclear prelamin A recognition factor (Iron-only hydrogenase-like protein 2) (IOP2)	NARF	Homo sapiens (Human)	456				lamin filament [GO:0005638]; nuclear lamina [GO:0005652]; nuclear lumen [GO:0031981]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	lamin binding [GO:0005521]	lamin filament [GO:0005638]; nuclear lamina [GO:0005652]; nuclear lumen [GO:0031981]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; lamin binding [GO:0005521]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10514485}.
Q9UHQ9	reviewed	NB5R1_HUMAN	NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (Humb5R2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2)	CYB5R1 NQO3A2 UNQ3049/PRO9865	Homo sapiens (Human)	305	FUNCTION: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}.		bicarbonate transport [GO:0015701]; sterol biosynthetic process [GO:0016126]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; FAD binding [GO:0071949]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; FAD binding [GO:0071949]; bicarbonate transport [GO:0015701]; sterol biosynthetic process [GO:0016126]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9UHR4	reviewed	BI2L1_HUMAN	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)	BAIAP2L1 IRTKS	Homo sapiens (Human)	511	FUNCTION: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}.		actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838]; regulation of actin cytoskeleton organization [GO:0032956]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; cadherin binding involved in cell-cell adhesion [GO:0098641]; proline-rich region binding [GO:0070064]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; cadherin binding involved in cell-cell adhesion [GO:0098641]; proline-rich region binding [GO:0070064]; actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838]; regulation of actin cytoskeleton organization [GO:0032956]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19366662}. Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
Q9UHR5	reviewed	S30BP_HUMAN	SAP30-binding protein (Transcriptional regulator protein HCNGP)	SAP30BP HCNGP HTRG HTRP	Homo sapiens (Human)	308	FUNCTION: Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (PubMed:21221920). May be involved in the regulation of beta-2-microglobulin genes (By similarity). {ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:21221920}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269|PubMed:21221920}.		modulation by host of symbiont transcription [GO:0052472]; regulation of DNA-templated transcription [GO:0006355]; response to virus [GO:0009615]	intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; modulation by host of symbiont transcription [GO:0052472]; regulation of DNA-templated transcription [GO:0006355]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15496587}.
Q9UHV2	reviewed	SRTD1_HUMAN	SERTA domain-containing protein 1 (CDK4-binding protein p34SEI1) (SEI-1) (p34(SEI-1)) (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1)	SERTAD1 SEI1 TRIPBR1	Homo sapiens (Human)	236	FUNCTION: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.		positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]	nucleus [GO:0005634]; sarcoplasm [GO:0016528]		nucleus [GO:0005634]; sarcoplasm [GO:0016528]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]	
Q9UHV7	reviewed	MED13_HUMAN	Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)	MED13 ARC250 KIAA0593 THRAP1 TRAP240	Homo sapiens (Human)	2174	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.		cholesterol homeostasis [GO:0042632]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; triglyceride homeostasis [GO:0070328]	CKM complex [GO:1990508]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	CKM complex [GO:1990508]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; cholesterol homeostasis [GO:0042632]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Nucleus.
Q9UHV8	reviewed	PP13_HUMAN	Galactoside-binding soluble lectin 13 (Galectin-13) (Gal-13) (Placental tissue protein 13) (PP13) (Placental protein 13)	LGALS13 PLAC8	Homo sapiens (Human)	139	FUNCTION: Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis (PubMed:10527825, PubMed:19497882). Has hemagglutinating activity towards chicken erythrocytes (PubMed:29343868). {ECO:0000269|PubMed:10527825, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:29343868}.		apoptotic process [GO:0006915]; phospholipid metabolic process [GO:0006644]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]	carbohydrate binding [GO:0030246]; lysophospholipase activity [GO:0004622]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; carbohydrate binding [GO:0030246]; lysophospholipase activity [GO:0004622]; apoptotic process [GO:0006915]; phospholipid metabolic process [GO:0006644]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29343868}. Nucleus matrix {ECO:0000269|PubMed:29343868}.
Q9UHV9	reviewed	PFD2_HUMAN	Prefoldin subunit 2	PFDN2 PFD2 HSPC231	Homo sapiens (Human)	154	FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.		chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; positive regulation of cytoskeleton organization [GO:0051495]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]	amyloid-beta binding [GO:0001540]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; amyloid-beta binding [GO:0001540]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; positive regulation of cytoskeleton organization [GO:0051495]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17936702}. Cytoplasm {ECO:0000269|PubMed:17936702}. Mitochondrion {ECO:0000269|PubMed:17936702}.
Q9UHW9	reviewed	S12A6_HUMAN	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)	SLC12A6 KCC3	Homo sapiens (Human)	1150	FUNCTION: [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:11551954, PubMed:10600773, PubMed:19665974, PubMed:18566107, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:34031912, PubMed:33199848). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Does not differ in the osmotic set point of swelling activation but, activation is more rapid. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Does not differ in the osmotic set point of swelling activation but, activation is more rapid. {ECO:0000305}.	ammonium import across plasma membrane [GO:0140157]; angiogenesis [GO:0001525]; cell volume homeostasis [GO:0006884]; cellular hypotonic response [GO:0071476]; cellular hypotonic salinity response [GO:0071477]; cellular response to glucose stimulus [GO:0071333]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]	axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	ammonium transmembrane transporter activity [GO:0008519]; metal ion binding [GO:0046872]; potassium ion transmembrane transporter activity [GO:0015079]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901]	axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; ammonium transmembrane transporter activity [GO:0008519]; metal ion binding [GO:0046872]; potassium ion transmembrane transporter activity [GO:0015079]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901]; ammonium import across plasma membrane [GO:0140157]; angiogenesis [GO:0001525]; cell volume homeostasis [GO:0006884]; cellular hypotonic response [GO:0071476]; cellular hypotonic salinity response [GO:0071477]; cellular response to glucose stimulus [GO:0071333]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12368912, ECO:0000269|PubMed:17893295, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q924N4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q924N4}.
Q9UHX1	reviewed	PUF60_HUMAN	Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)	PUF60 FIR ROBPI SIAHBP1	Homo sapiens (Human)	559	FUNCTION: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}.	MISCELLANEOUS: Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells.	alternative mRNA splicing, via spliceosome [GO:0000380]; apoptotic process [GO:0006915]; mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	cell junction [GO:0030054]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]	cadherin binding [GO:0045296]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]	cell junction [GO:0030054]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; cadherin binding [GO:0045296]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; alternative mRNA splicing, via spliceosome [GO:0000380]; apoptotic process [GO:0006915]; mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10668799, ECO:0000269|PubMed:17579712}. Note=Colocalizes partially with RO60. {ECO:0000269|PubMed:10668799}.
Q9UHX3	reviewed	AGRE2_HUMAN	Adhesion G protein-coupled receptor E2 (EGF-like module receptor 2) (EGF-like module-containing mucin-like hormone receptor-like 2) (CD antigen CD312)	ADGRE2 EMR2	Homo sapiens (Human)	823	FUNCTION: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242). {ECO:0000269|PubMed:12829604, ECO:0000269|PubMed:17928360, ECO:0000269|PubMed:22310662, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:26841242}.	MISCELLANEOUS: Has no murine ortholog. {ECO:0000305}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; regulation of mast cell degranulation [GO:0043304]	leading edge membrane [GO:0031256]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; G protein-coupled receptor activity [GO:0004930]	leading edge membrane [GO:0031256]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; regulation of mast cell degranulation [GO:0043304]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22310662, ECO:0000269|PubMed:26841242}; Multi-pass membrane protein. Cell projection, ruffle membrane {ECO:0000269|PubMed:17928360}; Multi-pass membrane protein. Note=Localized at the leading edge of migrating cells. {ECO:0000269|PubMed:17928360}.
Q9UHY1	reviewed	NRBP_HUMAN	Nuclear receptor-binding protein	NRBP1 BCON3 NRBP	Homo sapiens (Human)	535	FUNCTION: Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}.	MISCELLANEOUS: May act as a tumor suppressor to decrease tumor incidence and improve survival (PubMed:22510880). Expression levels have also been found to be reduced in a range of tumor types, such as leukemia, lymphoma, colorectal, breast, brain, esophageal, renal cell, prostate and lung (PubMed:22510880). {ECO:0000269|PubMed:22510880}.	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:11956649}. Endomembrane system {ECO:0000269|PubMed:11956649}. Cell projection, lamellipodium {ECO:0000269|PubMed:11956649}. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.
Q9UHY7	reviewed	ENOPH_HUMAN	Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase) (MASA homolog)	ENOPH1 MASA MSTP145	Homo sapiens (Human)	261	FUNCTION: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). {ECO:0000255|HAMAP-Rule:MF_03117, ECO:0000269|PubMed:15843022}.		L-methionine salvage from methylthioadenosine [GO:0019509]; L-methionine salvage from S-adenosylmethionine [GO:0019284]	cytosol [GO:0005829]; nucleus [GO:0005634]	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity [GO:0043715]; 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity [GO:0043716]; acireductone synthase activity [GO:0043874]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; nucleus [GO:0005634]; 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity [GO:0043715]; 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity [GO:0043716]; acireductone synthase activity [GO:0043874]; magnesium ion binding [GO:0000287]; L-methionine salvage from methylthioadenosine [GO:0019509]; L-methionine salvage from S-adenosylmethionine [GO:0019284]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03117}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03117}.
Q9UHY8	reviewed	FEZ2_HUMAN	Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2)	FEZ2	Homo sapiens (Human)	353	FUNCTION: Involved in axonal outgrowth and fasciculation. {ECO:0000250}.		axon guidance [GO:0007411]; negative regulation of autophagosome assembly [GO:1902902]; nervous system development [GO:0007399]; signal transduction [GO:0007165]	axon [GO:0030424]; cytoplasm [GO:0005737]		axon [GO:0030424]; cytoplasm [GO:0005737]; axon guidance [GO:0007411]; negative regulation of autophagosome assembly [GO:1902902]; nervous system development [GO:0007399]; signal transduction [GO:0007165]	
Q9UI08	reviewed	EVL_HUMAN	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like)	EVL RNB6	Homo sapiens (Human)	416	FUNCTION: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.	MISCELLANEOUS: Required to transform actin polymerization into active movement for the propulsive force of Listeria monocytogenes. {ECO:0000250}.	actin filament organization [GO:0007015]; actin polymerization or depolymerization [GO:0008154]; animal organ morphogenesis [GO:0009887]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; nervous system development [GO:0007399]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of stress fiber assembly [GO:0051496]; protein homotetramerization [GO:0051289]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]	actin binding [GO:0003779]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; actin binding [GO:0003779]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124]; actin filament organization [GO:0007015]; actin polymerization or depolymerization [GO:0008154]; animal organ morphogenesis [GO:0009887]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; nervous system development [GO:0007399]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of stress fiber assembly [GO:0051496]; protein homotetramerization [GO:0051289]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P70429}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:P70429}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P70429}. Note=Targeted to the leading edge of lamellipodia and the distal tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes. {ECO:0000250|UniProtKB:P70429}.
Q9UI09	reviewed	NDUAC_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (13 kDa differentiation-associated protein) (Complex I-B17.2) (CI-B17.2) (CIB17.2) (NADH-ubiquinone oxidoreductase subunit B17.2)	NDUFA12 DAP13	Homo sapiens (Human)	145	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.	MISCELLANEOUS: In NDUFA12-knockout cells, complex I assembly is not affected, probably due to substitution by the NDUFAF2 paralog. {ECO:0000269|PubMed:27626371}.	aerobic respiration [GO:0009060]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to oxidative stress [GO:0006979]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
Q9UI10	reviewed	EI2BD_HUMAN	Translation initiation factor eIF-2B subunit delta (eIF-2B GDP-GTP exchange factor subunit delta)	EIF2B4 EIF2BD	Homo sapiens (Human)	523	FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.; FUNCTION: (Microbial infection) In case of infection by influenza A virus; required for viral replication in tracheal cells. {ECO:0000269|PubMed:28169297}.		myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; regulation of translation [GO:0006417]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]	translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; regulation of translation [GO:0006417]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	
Q9UI12	reviewed	VATH_HUMAN	V-type proton ATPase subunit H (V-ATPase subunit H) (Nef-binding protein 1) (NBP1) (Protein VMA13 homolog) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD)	ATP6V1H CGI-11	Homo sapiens (Human)	483	FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (PubMed:12032142). {ECO:0000250|UniProtKB:O46563, ECO:0000250|UniProtKB:P41807, ECO:0000269|PubMed:12032142, ECO:0000269|PubMed:33065002}.		endocytosis [GO:0006897]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	enzyme regulator activity [GO:0030234]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]; enzyme regulator activity [GO:0030234]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; endocytosis [GO:0006897]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:O46563}; Peripheral membrane protein {ECO:0000305}.
Q9UI14	reviewed	PRAF1_HUMAN	Prenylated Rab acceptor protein 1 (PRA1 family protein 1)	RABAC1 PRA1 PRAF1	Homo sapiens (Human)	185	FUNCTION: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI. {ECO:0000250|UniProtKB:O35394}.			Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; proline-rich region binding [GO:0070064]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; proline-rich region binding [GO:0070064]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O35394}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O35394}. Golgi apparatus {ECO:0000250|UniProtKB:O35394}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:O35394}. Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles. {ECO:0000250|UniProtKB:O35394}.
Q9UI17	reviewed	M2GD_HUMAN	Dimethylglycine dehydrogenase, mitochondrial (EC 1.5.8.4) (ME2GLYDH)	DMGDH	Homo sapiens (Human)	866	FUNCTION: Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro. {ECO:0000269|PubMed:27486859}.		amino-acid betaine catabolic process [GO:0006579]; choline catabolic process [GO:0042426]; choline metabolic process [GO:0019695]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	dimethylglycine dehydrogenase activity [GO:0047865]; electron transfer activity [GO:0009055]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; dimethylglycine dehydrogenase activity [GO:0047865]; electron transfer activity [GO:0009055]; RNA binding [GO:0003723]; amino-acid betaine catabolic process [GO:0006579]; choline catabolic process [GO:0042426]; choline metabolic process [GO:0019695]	SUBCELLULAR LOCATION: Mitochondrion.
Q9UI26	reviewed	IPO11_HUMAN	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11)	IPO11 RANBP11	Homo sapiens (Human)	975	FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11032817}.		protein import into nucleus [GO:0006606]; ribosomal protein import into nucleus [GO:0006610]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]	nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267]; protein import into nucleus [GO:0006606]; ribosomal protein import into nucleus [GO:0006610]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11032817}. Nucleus {ECO:0000269|PubMed:11032817}.
Q9UI30	reviewed	TR112_HUMAN	Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog)	TRMT112 AD-001 HSPC152 HSPC170	Homo sapiens (Human)	125	FUNCTION: Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:25851604, PubMed:18539146, PubMed:20308323, PubMed:25851604, PubMed:31328227, PubMed:31636962, PubMed:31061526). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). The heterodimer with N6AMT1/HEMK2 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146, PubMed:31636962, PubMed:31061526). The heterodimer with N6AMT1/HEMK2 also monomethylates 'Lys-12' of histone H4 (H4K12me1) (PubMed:31061526). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323). Together with methyltransferase THUMPD3, catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) (PubMed:34669960). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604). Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:33428944, PubMed:35033535, PubMed:31328227). {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:25851604, ECO:0000269|PubMed:31061526, ECO:0000269|PubMed:31328227, ECO:0000269|PubMed:31636962, ECO:0000269|PubMed:33428944, ECO:0000269|PubMed:34669960}.		peptidyl-glutamine methylation [GO:0018364]; positive regulation of rRNA processing [GO:2000234]; rRNA (guanine-N7)-methylation [GO:0070476]; rRNA methylation [GO:0031167]; transcription initiation-coupled chromatin remodeling [GO:0045815]; tRNA methylation [GO:0030488]; tRNA N2-guanine methylation [GO:0002940]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	protein heterodimerization activity [GO:0046982]; protein methyltransferase activity [GO:0008276]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; protein heterodimerization activity [GO:0046982]; protein methyltransferase activity [GO:0008276]; peptidyl-glutamine methylation [GO:0018364]; positive regulation of rRNA processing [GO:2000234]; rRNA (guanine-N7)-methylation [GO:0070476]; rRNA methylation [GO:0031167]; transcription initiation-coupled chromatin remodeling [GO:0045815]; tRNA methylation [GO:0030488]; tRNA N2-guanine methylation [GO:0002940]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:25851604}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:25851604}. Note=Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604). {ECO:0000269|PubMed:25851604}.
Q9UI32	reviewed	GLSL_HUMAN	Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase)	GLS2 GA	Homo sapiens (Human)	602	FUNCTION: Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. {ECO:0000269|PubMed:20378837}.		amino acid metabolic process [GO:0006520]; glutamate biosynthetic process [GO:0006537]; glutamine catabolic process [GO:0006543]; reactive oxygen species metabolic process [GO:0072593]; regulation of apoptotic process [GO:0042981]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	glutaminase activity [GO:0004359]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; glutaminase activity [GO:0004359]; amino acid metabolic process [GO:0006520]; glutamate biosynthetic process [GO:0006537]; glutamine catabolic process [GO:0006543]; reactive oxygen species metabolic process [GO:0072593]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20378837}.
Q9UI33	reviewed	SCNBA_HUMAN	Sodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (hNaN)	SCN11A SCN12A SNS2	Homo sapiens (Human)	1791	FUNCTION: Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient (PubMed:10580103, PubMed:12384689, PubMed:24036948, PubMed:24776970, PubMed:26645915, PubMed:25791876). Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system (PubMed:24036948, PubMed:24776970, PubMed:26645915, PubMed:25791876). Also involved in rapid BDNF-evoked neuronal depolarization (PubMed:12384689). {ECO:0000269|PubMed:10580103, ECO:0000269|PubMed:12384689, ECO:0000269|PubMed:24036948, ECO:0000269|PubMed:24776970, ECO:0000269|PubMed:25791876, ECO:0000269|PubMed:26645915}.		action potential initiation [GO:0099610]; acute inflammatory response [GO:0002526]; artery development [GO:0060840]; axonogenesis [GO:0007409]; behavioral response to acetic acid induced pain [GO:0061367]; behavioral response to formalin induced pain [GO:0061368]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion import across plasma membrane [GO:0098703]; cell motility [GO:0048870]; cellular response to cold [GO:0070417]; chronic inflammatory response [GO:0002544]; circadian rhythm [GO:0007623]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; mast cell degranulation [GO:0043303]; membrane depolarization during action potential [GO:0086010]; micturition [GO:0060073]; neuronal action potential [GO:0019228]; protein kinase A signaling [GO:0010737]; reflex [GO:0060004]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to auditory stimulus [GO:0010996]; response to heat [GO:0009408]; response to high light intensity [GO:0009644]; response to nitric oxide [GO:0071731]; response to prostaglandin E [GO:0034695]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; sensory perception of itch [GO:0160025]; sensory perception of pain [GO:0019233]; skeletal muscle organ development [GO:0060538]; small intestine smooth muscle contraction [GO:1990770]; thermosensory behavior [GO:0040040]; thigmotaxis [GO:0001966]	axon [GO:0030424]; axonal growth cone [GO:0044295]; C-fiber [GO:0044299]; extracellular exosome [GO:0070062]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]	high voltage-gated calcium channel activity [GO:0008331]; voltage-gated sodium channel activity [GO:0005248]	axon [GO:0030424]; axonal growth cone [GO:0044295]; C-fiber [GO:0044299]; extracellular exosome [GO:0070062]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated sodium channel activity [GO:0005248]; action potential initiation [GO:0099610]; acute inflammatory response [GO:0002526]; artery development [GO:0060840]; axonogenesis [GO:0007409]; behavioral response to acetic acid induced pain [GO:0061367]; behavioral response to formalin induced pain [GO:0061368]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion import across plasma membrane [GO:0098703]; cell motility [GO:0048870]; cellular response to cold [GO:0070417]; chronic inflammatory response [GO:0002544]; circadian rhythm [GO:0007623]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; mast cell degranulation [GO:0043303]; membrane depolarization during action potential [GO:0086010]; micturition [GO:0060073]; neuronal action potential [GO:0019228]; protein kinase A signaling [GO:0010737]; reflex [GO:0060004]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to auditory stimulus [GO:0010996]; response to heat [GO:0009408]; response to high light intensity [GO:0009644]; response to nitric oxide [GO:0071731]; response to prostaglandin E [GO:0034695]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; sensory perception of itch [GO:0160025]; sensory perception of pain [GO:0019233]; skeletal muscle organ development [GO:0060538]; small intestine smooth muscle contraction [GO:1990770]; thermosensory behavior [GO:0040040]; thigmotaxis [GO:0001966]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12384689, ECO:0000269|PubMed:24036948}; Multi-pass membrane protein {ECO:0000255}.
Q9UI36	reviewed	DACH1_HUMAN	Dachshund homolog 1 (Dach1)	DACH1 DACH	Homo sapiens (Human)	758	FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250, ECO:0000269|PubMed:14525983}.	MISCELLANEOUS: [Isoform 2]: Major. {ECO:0000305}.	development of primary female sexual characteristics [GO:0046545]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of nuclear cell cycle DNA replication [GO:0033262]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory gaseous exchange by respiratory system [GO:0007585]; suckling behavior [GO:0001967]; type B pancreatic cell proliferation [GO:0044342]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; development of primary female sexual characteristics [GO:0046545]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of nuclear cell cycle DNA replication [GO:0033262]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory gaseous exchange by respiratory system [GO:0007585]; suckling behavior [GO:0001967]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14525983}.
Q9UI38	reviewed	TSP50_HUMAN	Probable threonine protease PRSS50 (EC 3.4.25.-) (Cancer/testis antigen 20) (Serine protease 50) (Testis-specific protease-like protein 50)	PRSS50 CT20 TSP50	Homo sapiens (Human)	385	FUNCTION: May be involved in proteolysis through its threonine endopeptidase activity. {ECO:0000269|PubMed:17283160}.	MISCELLANEOUS: DNA hypomethylation is accompanied by the expression of the gene in the testis.	proteolysis [GO:0006508]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]	serine-type endopeptidase activity [GO:0004252]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; serine-type endopeptidase activity [GO:0004252]; threonine-type endopeptidase activity [GO:0004298]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000305|PubMed:17283160}. Note=May also localize to cytoplasmic membranes.
Q9UI40	reviewed	NCKX2_HUMAN	Sodium/potassium/calcium exchanger 2 (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2)	SLC24A2 NCKX2	Homo sapiens (Human)	661	FUNCTION: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:10662833, PubMed:26631410). Required for learming and memory by regulating neuronal Ca(2+), which is essential for the development of synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q8BUN9, ECO:0000269|PubMed:10662833, ECO:0000269|PubMed:26631410}.		calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to high light intensity [GO:0071486]; cone photoresponse recovery [GO:0036368]; establishment of localization in cell [GO:0051649]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; neuron cellular homeostasis [GO:0070050]; phototransduction [GO:0007602]; potassium ion transmembrane transport [GO:0071805]; sodium ion transmembrane transport [GO:0035725]	photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]	photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to high light intensity [GO:0071486]; cone photoresponse recovery [GO:0036368]; establishment of localization in cell [GO:0051649]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; neuron cellular homeostasis [GO:0070050]; phototransduction [GO:0007602]; potassium ion transmembrane transport [GO:0071805]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26631410}; Multi-pass membrane protein {ECO:0000255}.
Q9UI42	reviewed	CBPA4_HUMAN	Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)	CPA4 CPA3 UNQ694/PRO1339	Homo sapiens (Human)	421	FUNCTION: Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). {ECO:0000269|PubMed:10383164, ECO:0000269|PubMed:20385563}.		histone acetylation [GO:0016573]; proteolysis [GO:0006508]	extracellular space [GO:0005615]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	extracellular space [GO:0005615]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; histone acetylation [GO:0016573]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q9UI43	reviewed	MRM2_HUMAN	rRNA methyltransferase 2, mitochondrial (EC 2.1.1.-) (16S rRNA (uridine(1369)-2'-O)-methyltransferase) (16S rRNA [Um1369] 2'-O-methyltransferase) (Protein ftsJ homolog 2)	MRM2 FJH1 FTSJ2	Homo sapiens (Human)	246	FUNCTION: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. {ECO:0000269|PubMed:25009282, ECO:0000269|PubMed:25074936}.		mitochondrial large ribosomal subunit assembly [GO:1902775]; RNA methylation [GO:0001510]; rRNA 2'-O-methylation [GO:0000451]; rRNA methylation [GO:0031167]; rRNA processing [GO:0006364]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	rRNA (uridine-2'-O-)-methyltransferase activity [GO:0008650]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; rRNA (uridine-2'-O-)-methyltransferase activity [GO:0008650]; mitochondrial large ribosomal subunit assembly [GO:1902775]; RNA methylation [GO:0001510]; rRNA 2'-O-methylation [GO:0000451]; rRNA methylation [GO:0031167]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:24036117, ECO:0000269|PubMed:25009282}.
Q9UI46	reviewed	DNAI1_HUMAN	Dynein axonemal intermediate chain 1 (Axonemal dynein intermediate chain 1)	DNAI1	Homo sapiens (Human)	699	FUNCTION: Part of the dynein complex of respiratory cilia.		cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; outer dynein arm assembly [GO:0036158]	9+2 motile cilium [GO:0097729]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoskeleton [GO:0005856]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]	cytoskeletal motor activity [GO:0003774]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]	9+2 motile cilium [GO:0097729]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoskeleton [GO:0005856]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; cytoskeletal motor activity [GO:0003774]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; outer dynein arm assembly [GO:0036158]	SUBCELLULAR LOCATION: Dynein axonemal particle {ECO:0000269|PubMed:33263282}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:27120127}.
Q9UI47	reviewed	CTNA3_HUMAN	Catenin alpha-3 (Alpha T-catenin) (Cadherin-associated protein)	CTNNA3	Homo sapiens (Human)	895	FUNCTION: May be involved in formation of stretch-resistant cell-cell adhesion complexes. {ECO:0000303|PubMed:11590244}.		bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; desmosome [GO:0030057]; fascia adherens [GO:0005916]; lamellipodium [GO:0030027]	actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; desmosome [GO:0030057]; fascia adherens [GO:0005916]; lamellipodium [GO:0030027]; actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q65CL1}. Note=Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. Colocalizes with PKP2 at intercalated disks in the heart (By similarity). {ECO:0000250|UniProtKB:Q65CL1, ECO:0000269|PubMed:11590244}.
Q9UI95	reviewed	MD2L2_HUMAN	Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (REV7 homolog) (hREV7)	MAD2L2 MAD2B REV7	Homo sapiens (Human)	211	FUNCTION: Adapter protein able to interact with different proteins and involved in different biological processes (PubMed:11459825, PubMed:11459826, PubMed:17719540, PubMed:17296730, PubMed:19443654, PubMed:29656893). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:20164194). Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions (PubMed:20164194). Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 (PubMed:17296730). Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle (PubMed:11459825, PubMed:17719540). Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (PubMed:19443654). {ECO:0000269|PubMed:11459825, ECO:0000269|PubMed:11459826, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:17719540, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:20164194, ECO:0000269|PubMed:29656893}.		actin filament organization [GO:0007015]; cell division [GO:0051301]; DNA damage response, signal transduction resulting in transcription [GO:0042772]; double-strand break repair [GO:0006302]; error-prone translesion synthesis [GO:0042276]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of isotype switching [GO:0045830]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of cell growth [GO:0001558]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; spindle [GO:0005819]; zeta DNA polymerase complex [GO:0016035]	JUN kinase binding [GO:0008432]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; spindle [GO:0005819]; zeta DNA polymerase complex [GO:0016035]; JUN kinase binding [GO:0008432]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; actin filament organization [GO:0007015]; cell division [GO:0051301]; DNA damage response, signal transduction resulting in transcription [GO:0042772]; double-strand break repair [GO:0006302]; error-prone translesion synthesis [GO:0042276]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of isotype switching [GO:0045830]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of cell growth [GO:0001558]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11717438, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:17719540, ECO:0000269|PubMed:19753112}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19753112, ECO:0000269|PubMed:21063390}. Cytoplasm {ECO:0000269|PubMed:11717438, ECO:0000269|PubMed:17719540}. Chromosome {ECO:0000269|PubMed:29656893}. Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle. {ECO:0000269|PubMed:29656893}.
Q9UIA0	reviewed	CYH4_HUMAN	Cytohesin-4 (PH, SEC7 and coiled-coil domain-containing protein 4)	CYTH4 CYT4 PSCD4	Homo sapiens (Human)	394	FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP. {ECO:0000269|PubMed:10652308}.		regulation of ARF protein signal transduction [GO:0032012]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289]; regulation of ARF protein signal transduction [GO:0032012]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17398095}; Peripheral membrane protein {ECO:0000269|PubMed:17398095}.
Q9UIA9	reviewed	XPO7_HUMAN	Exportin-7 (Exp7) (Ran-binding protein 16)	XPO7 KIAA0745 RANBP16	Homo sapiens (Human)	1087	FUNCTION: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:11024021, ECO:0000269|PubMed:15282546}.		protein export from nucleus [GO:0006611]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleus [GO:0005634]	nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267]; protein export from nucleus [GO:0006611]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11024021, ECO:0000269|PubMed:22509282}. Nucleus {ECO:0000269|PubMed:11024021}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:11024021}.
Q9UIB8	reviewed	SLAF5_HUMAN	SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)	CD84 SLAMF5	Homo sapiens (Human)	345	FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647, PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592). {ECO:0000250|UniProtKB:Q18PI6, ECO:0000269|PubMed:11564780, ECO:0000269|PubMed:12115647, ECO:0000269|PubMed:12928397, ECO:0000269|PubMed:12962726, ECO:0000269|PubMed:16037392, ECO:0000269|PubMed:22068234, ECO:0000269|PubMed:29434592, ECO:0000305}.		adaptive immune response [GO:0002250]; autophagy [GO:0006914]; defense response [GO:0006952]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; innate immune response [GO:0045087]; negative regulation of granulocyte macrophage colony-stimulating factor production [GO:0032685]; negative regulation of interleukin-18 production [GO:0032701]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of mast cell activation [GO:0033004]; negative regulation of mast cell degranulation [GO:0043305]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of macrophage activation [GO:0043030]; regulation of store-operated calcium entry [GO:2001256]; T cell activation [GO:0042110]	external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; adaptive immune response [GO:0002250]; autophagy [GO:0006914]; defense response [GO:0006952]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; innate immune response [GO:0045087]; negative regulation of granulocyte macrophage colony-stimulating factor production [GO:0032685]; negative regulation of interleukin-18 production [GO:0032701]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of mast cell activation [GO:0033004]; negative regulation of mast cell degranulation [GO:0043305]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of macrophage activation [GO:0043030]; regulation of store-operated calcium entry [GO:2001256]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11389028, ECO:0000269|PubMed:12962726}; Single-pass type I membrane protein {ECO:0000269|PubMed:11389028, ECO:0000269|PubMed:12962726}.
Q9UIC8	reviewed	LCMT1_HUMAN	Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) (Protein-leucine O-methyltransferase) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1)	LCMT1 LCMT CGI-68	Homo sapiens (Human)	334	FUNCTION: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. {ECO:0000269|PubMed:10600115}.		C-terminal protein methylation [GO:0006481]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of protein-containing complex assembly [GO:0031333]; protein methylation [GO:0006479]; protein modification process [GO:0036211]; regulation of apoptotic process [GO:0042981]; regulation of glucose metabolic process [GO:0010906]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	protein C-terminal carboxyl O-methyltransferase activity [GO:0003880]; protein C-terminal leucine carboxyl O-methyltransferase activity [GO:0018423]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein C-terminal carboxyl O-methyltransferase activity [GO:0003880]; protein C-terminal leucine carboxyl O-methyltransferase activity [GO:0018423]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; C-terminal protein methylation [GO:0006481]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of protein-containing complex assembly [GO:0031333]; protein methylation [GO:0006479]; protein modification process [GO:0036211]; regulation of apoptotic process [GO:0042981]; regulation of glucose metabolic process [GO:0010906]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	
Q9UID3	reviewed	VPS51_HUMAN	Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog)	VPS51 ANG2 C11orf2 C11orf3 FFR PP5382	Homo sapiens (Human)	782	FUNCTION: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:20685960, ECO:0000269|PubMed:25799061}.		autophagy [GO:0006914]; brain morphogenesis [GO:0048854]; endocytic recycling [GO:0032456]; Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; lysosomal transport [GO:0007041]; protein targeting [GO:0006605]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]	cytosol [GO:0005829]; EARP complex [GO:1990745]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588]		cytosol [GO:0005829]; EARP complex [GO:1990745]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588]; autophagy [GO:0006914]; brain morphogenesis [GO:0048854]; endocytic recycling [GO:0032456]; Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; lysosomal transport [GO:0007041]; protein targeting [GO:0006605]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:20685960}. Recycling endosome {ECO:0000269|PubMed:25799061}. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061). {ECO:0000269|PubMed:25799061}.
Q9UID6	reviewed	ZN639_HUMAN	Zinc finger protein 639 (Zinc finger protein ANC_2H01) (Zinc finger protein ZASC1)	ZNF639 ZASC1	Homo sapiens (Human)	485	FUNCTION: Binds DNA and may function as a transcriptional repressor. {ECO:0000269|PubMed:16182284}.		negative regulation by host of viral transcription [GO:0043922]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell growth [GO:0030307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; viral entry into host cell [GO:0046718]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; protein self-association [GO:0043621]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; protein self-association [GO:0043621]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell growth [GO:0030307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; viral entry into host cell [GO:0046718]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14522885, ECO:0000269|PubMed:16182284}.
Q9UIE0	reviewed	ZN230_HUMAN	Zinc finger protein 230 (Zinc finger protein FDZF2)	ZNF230 FDZF2	Homo sapiens (Human)	474	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UIF7	reviewed	MUTYH_HUMAN	Adenine DNA glycosylase (EC 3.2.2.31) (MutY homolog) (hMYH)	MUTYH MYH	Homo sapiens (Human)	546	FUNCTION: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. {ECO:0000269|PubMed:10684930, ECO:0000269|PubMed:20418187, ECO:0000269|PubMed:20848659, ECO:0000269|PubMed:25820570, ECO:0000269|PubMed:26694661}.		base-excision repair [GO:0006284]; depurination [GO:0045007]; DNA repair [GO:0006281]; mismatch repair [GO:0006298]; negative regulation of necroptotic process [GO:0060546]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	4 iron, 4 sulfur cluster binding [GO:0051539]; 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; adenine/guanine mispair binding [GO:0035485]; DNA N-glycosylase activity [GO:0019104]; metal ion binding [GO:0046872]; MutSalpha complex binding [GO:0032407]; oxidized purine DNA binding [GO:0032357]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 4 iron, 4 sulfur cluster binding [GO:0051539]; 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; adenine/guanine mispair binding [GO:0035485]; DNA N-glycosylase activity [GO:0019104]; metal ion binding [GO:0046872]; MutSalpha complex binding [GO:0032407]; oxidized purine DNA binding [GO:0032357]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]; base-excision repair [GO:0006284]; depurination [GO:0045007]; DNA repair [GO:0006281]; mismatch repair [GO:0006298]; negative regulation of necroptotic process [GO:0060546]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25820570}. Mitochondrion {ECO:0000250|UniProtKB:Q99P21}.
Q9UIF8	reviewed	BAZ2B_HUMAN	Bromodomain adjacent to zinc finger domain protein 2B (hWALp4)	BAZ2B KIAA1476	Homo sapiens (Human)	2168	FUNCTION: Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}.		chromatin remodeling [GO:0006338]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; chromatin remodeling [GO:0006338]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063, ECO:0000269|PubMed:25593309}.
Q9UIF9	reviewed	BAZ2A_HUMAN	Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3)	BAZ2A KIAA0314 TIP5	Homo sapiens (Human)	1905	FUNCTION: Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}.		chromatin remodeling [GO:0006338]; DNA methylation [GO:0006306]; DNA-templated transcription [GO:0006351]; heterochromatin formation [GO:0031507]; negative regulation of transcription by RNA polymerase I [GO:0016479]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of histone methylation [GO:0031062]; rDNA heterochromatin formation [GO:0000183]; regulation of DNA methylation [GO:0044030]; regulation of DNA-templated transcription [GO:0006355]; RNA polymerase I preinitiation complex assembly [GO:0001188]	chromatin silencing complex [GO:0005677]; cytosol [GO:0005829]; NoRC complex [GO:0090536]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; rDNA heterochromatin [GO:0033553]	DNA binding [GO:0003677]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; nuclear receptor binding [GO:0016922]; RNA binding [GO:0003723]	chromatin silencing complex [GO:0005677]; cytosol [GO:0005829]; NoRC complex [GO:0090536]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; rDNA heterochromatin [GO:0033553]; DNA binding [GO:0003677]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; nuclear receptor binding [GO:0016922]; RNA binding [GO:0003723]; chromatin remodeling [GO:0006338]; DNA methylation [GO:0006306]; DNA-templated transcription [GO:0006351]; heterochromatin formation [GO:0031507]; negative regulation of transcription by RNA polymerase I [GO:0016479]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of histone methylation [GO:0031062]; rDNA heterochromatin formation [GO:0000183]; regulation of DNA methylation [GO:0044030]; regulation of DNA-templated transcription [GO:0006355]; RNA polymerase I preinitiation complex assembly [GO:0001188]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q91YE5, ECO:0000305|PubMed:25593309}. Note=Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus. {ECO:0000250|UniProtKB:Q91YE5}.
Q9UIG0	reviewed	BAZ1B_HUMAN	Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2)	BAZ1B WBSC10 WBSCR10 WBSCR9 WSTF	Homo sapiens (Human)	1483	FUNCTION: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}.		chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; negative regulation of mitotic chromosome condensation [GO:1905213]; phosphorylation [GO:0016310]; positive regulation of histone acetylation [GO:0035066]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; post-translational protein modification [GO:0043687]; regulation of transcription by RNA polymerase II [GO:0006357]	B-WICH complex [GO:0110016]; condensed chromosome [GO:0000793]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; WICH complex [GO:0090535]	ATP binding [GO:0005524]; histone binding [GO:0042393]; histone H2AXY142 kinase activity [GO:0140801]; histone kinase activity [GO:0035173]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; zinc ion binding [GO:0008270]	B-WICH complex [GO:0110016]; condensed chromosome [GO:0000793]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; WICH complex [GO:0090535]; ATP binding [GO:0005524]; histone binding [GO:0042393]; histone H2AXY142 kinase activity [GO:0140801]; histone kinase activity [GO:0035173]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; zinc ion binding [GO:0008270]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; negative regulation of mitotic chromosome condensation [GO:1905213]; phosphorylation [GO:0016310]; positive regulation of histone acetylation [GO:0035066]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; post-translational protein modification [GO:0043687]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063, ECO:0000255|PROSITE-ProRule:PRU00475, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:25593309}. Note=Accumulates in pericentromeric heterochromatin during replication (PubMed:15543136). Co-localizes with PCNA at replication foci during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H at replication foci during late-S phase (PubMed:15543136). Also localizes to replication foci independently of SMARCA5/SNF2H and PCNA (PubMed:15543136). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:25593309}.
Q9UIG4	reviewed	PS1C2_HUMAN	Psoriasis susceptibility 1 candidate gene 2 protein (Protein SPR1)	PSORS1C2 C6orf17 SPR1	Homo sapiens (Human)	136				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9UIG8	reviewed	SO3A1_HUMAN	Solute carrier organic anion transporter family member 3A1 (OATP3A1) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (Organic anion-transporting polypeptide D) (OATP-D) (PGE1 transporter) (Sodium-independent organic anion transporter D) (Solute carrier family 21 member 11)	SLCO3A1 OATP3A1 OATPD SLC21A11	Homo sapiens (Human)	710	FUNCTION: Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycochenodeoxycholate and peptide hormones such as L-arginine vasopressin, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:14631946, PubMed:16971491, PubMed:19129463, PubMed:30063921). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:14631946, ECO:0000269|PubMed:16971491, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30063921, ECO:0000305}.		monoatomic ion transport [GO:0006811]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; prostaglandin transport [GO:0015732]; sodium-independent organic anion transport [GO:0043252]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; monoatomic ion transport [GO:0006811]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; prostaglandin transport [GO:0015732]; sodium-independent organic anion transport [GO:0043252]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: [Isoform 1]: Basolateral cell membrane {ECO:0000269|PubMed:16971491}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the basolateral membrane of choroid plexus epithelium. {ECO:0000269|PubMed:16971491}.; SUBCELLULAR LOCATION: [Isoform 2]: Apical cell membrane {ECO:0000269|PubMed:16971491}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the basal membrane of Sertoli cells (PubMed:35307651). Localized to the apical membrane of choroid plexus epithelium (PubMed:16971491). {ECO:0000269|PubMed:16971491, ECO:0000269|PubMed:35307651}.
Q9UIH9	reviewed	KLF15_HUMAN	Krueppel-like factor 15 (Kidney-enriched krueppel-like factor)	KLF15 KKLF	Homo sapiens (Human)	416	FUNCTION: Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. {ECO:0000250, ECO:0000269|PubMed:18586263, ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:20566642, ECO:0000269|PubMed:23999430}.		cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to peptide [GO:1901653]; glial cell differentiation [GO:0010001]; intracellular glucose homeostasis [GO:0001678]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; podocyte differentiation [GO:0072112]; positive regulation of glucose import [GO:0046326]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]; response to insulin [GO:0032868]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to peptide [GO:1901653]; glial cell differentiation [GO:0010001]; intracellular glucose homeostasis [GO:0001678]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; podocyte differentiation [GO:0072112]; positive regulation of glucose import [GO:0046326]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]; response to insulin [GO:0032868]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10982849, ECO:0000269|PubMed:17438289}.
Q9UII2	reviewed	ATIF1_HUMAN	ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1)	ATP5IF1 ATPI ATPIF1	Homo sapiens (Human)	106	FUNCTION: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269|PubMed:12110673, ECO:0000269|PubMed:15528193, ECO:0000269|PubMed:19559621, ECO:0000269|PubMed:23135403}.		angiogenesis [GO:0001525]; erythrocyte differentiation [GO:0030218]; generation of precursor metabolites and energy [GO:0006091]; heme biosynthetic process [GO:0006783]; mitochondrial depolarization [GO:0051882]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of hydrolase activity [GO:0051346]; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [GO:1904925]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; reactive oxygen species metabolic process [GO:0072593]; regulation of ATP metabolic process [GO:1903578]; regulation of protein targeting to mitochondrion [GO:1903214]	cell surface [GO:0009986]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	angiostatin binding [GO:0043532]; ATPase binding [GO:0051117]; ATPase inhibitor activity [GO:0042030]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; mitochondrial proton-transporting ATP synthase complex binding [GO:0140260]	cell surface [GO:0009986]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; angiostatin binding [GO:0043532]; ATPase binding [GO:0051117]; ATPase inhibitor activity [GO:0042030]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; mitochondrial proton-transporting ATP synthase complex binding [GO:0140260]; angiogenesis [GO:0001525]; erythrocyte differentiation [GO:0030218]; generation of precursor metabolites and energy [GO:0006091]; heme biosynthetic process [GO:0006783]; mitochondrial depolarization [GO:0051882]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of hydrolase activity [GO:0051346]; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [GO:1904925]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; reactive oxygen species metabolic process [GO:0072593]; regulation of ATP metabolic process [GO:1903578]; regulation of protein targeting to mitochondrion [GO:1903214]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12110673}.
Q9UII4	reviewed	HERC5_HUMAN	E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)	HERC5 CEB1 CEBP1	Homo sapiens (Human)	1024	FUNCTION: Major E3 ligase for ISG15 conjugation (PubMed:27534820, PubMed:34572049, PubMed:37279284). Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Mediates ISGylation of the phosphatase PTEN leading to its degradation, thus alleviating its suppression of the PI3K-AKT signaling pathway and promoting the production of cytokines that facilitate bacterial clearance (PubMed:37279284). Interferes with the function of key viral structural proteins such as ebolavirus structural protein VP40 or HIV-1 protein GAG (PubMed:22093708, PubMed:34572049). Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. Promotes parkin/PRKN ubiquitin E3 ligase activity by suppressing the intramolecular interaction that maintains its autoinhibited conformation (PubMed:27534820). {ECO:0000269|PubMed:16407192, ECO:0000269|PubMed:16815975, ECO:0000269|PubMed:16884686, ECO:0000269|PubMed:20133869, ECO:0000269|PubMed:20308324, ECO:0000269|PubMed:20385878, ECO:0000269|PubMed:20542004, ECO:0000269|PubMed:22093708, ECO:0000269|PubMed:27534820, ECO:0000269|PubMed:34572049, ECO:0000269|PubMed:37279284}.; FUNCTION: (Microbial infection) Functions as an E3 ligase for ISGylation of hepatitis B virus protein X leading to enhanced viral replication due to increased interferon resistance. {ECO:0000269|PubMed:34661519}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; ISG15-protein conjugation [GO:0032020]; protein ubiquitination [GO:0016567]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of defense response to virus [GO:0050688]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]	ISG15 transferase activity [GO:0042296]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; ISG15 transferase activity [GO:0042296]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; ISG15-protein conjugation [GO:0032020]; protein ubiquitination [GO:0016567]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of defense response to virus [GO:0050688]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:20542004}. Cytoplasm {ECO:0000269|PubMed:22093708}. Note=Associated with the polyribosomes, probably via the 60S subunit.
Q9UII6	reviewed	DS13B_HUMAN	Dual specificity protein phosphatase 13B (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase SKRP4) (Testis- and skeletal-muscle-specific DSP)	DUSP13B DUSP13 SKRP4 TMDP	Homo sapiens (Human)	198	FUNCTION: Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro (PubMed:21360282). Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro (PubMed:10585869). {ECO:0000269|PubMed:10585869, ECO:0000269|PubMed:21360282}.		dephosphorylation [GO:0016311]; meiotic cell cycle [GO:0051321]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]	MAP kinase phosphatase activity [GO:0033549]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; MAP kinase phosphatase activity [GO:0033549]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; dephosphorylation [GO:0016311]; meiotic cell cycle [GO:0051321]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]; spermatogenesis [GO:0007283]	
Q9UIJ5	reviewed	ZDHC2_HUMAN	Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372)	ZDHHC2 REAM REC ZNF372	Homo sapiens (Human)	367	FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18508921, PubMed:18296695, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). {ECO:0000250|UniProtKB:P59267, ECO:0000250|UniProtKB:Q9JKR5, ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:19144824, ECO:0000269|PubMed:21343290, ECO:0000269|PubMed:22034844, ECO:0000269|PubMed:23793055}.; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. {ECO:0000269|PubMed:30404808}.		peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of AMPA glutamate receptor clustering [GO:1904719]; positive regulation of endosome to plasma membrane protein transport [GO:1905751]; positive regulation of long-term synaptic potentiation [GO:1900273]; protein localization to membrane raft [GO:1903044]; protein localization to plasma membrane [GO:0072659]; protein localization to postsynaptic membrane [GO:1903539]; protein metabolic process [GO:0019538]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; regulation of cell-cell adhesion [GO:0022407]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of protein catabolic process [GO:0042176]; regulation of protein localization to plasma membrane [GO:1903076]; synapse assembly [GO:0007416]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic recycling endosome [GO:0098837]; recycling endosome membrane [GO:0055038]	palmitoyltransferase activity [GO:0016409]; protein homodimerization activity [GO:0042803]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic recycling endosome [GO:0098837]; recycling endosome membrane [GO:0055038]; palmitoyltransferase activity [GO:0016409]; protein homodimerization activity [GO:0042803]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of AMPA glutamate receptor clustering [GO:1904719]; positive regulation of endosome to plasma membrane protein transport [GO:1905751]; positive regulation of long-term synaptic potentiation [GO:1900273]; protein localization to membrane raft [GO:1903044]; protein localization to plasma membrane [GO:0072659]; protein localization to postsynaptic membrane [GO:1903539]; protein metabolic process [GO:0019538]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; regulation of cell-cell adhesion [GO:0022407]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of protein catabolic process [GO:0042176]; regulation of protein localization to plasma membrane [GO:1903076]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250|UniProtKB:Q9JKR5}. Postsynaptic recycling endosome membrane {ECO:0000250|UniProtKB:P59267}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:21471008}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22034844}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:22034844}; Multi-pass membrane protein {ECO:0000255}. Note=Translocates to postsynaptic density when synaptic activity decreases. {ECO:0000250|UniProtKB:Q9JKR5}.
Q9UIJ7	reviewed	KAD3_HUMAN	GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (AK 3) (Adenylate kinase 3 alpha-like 1)	AK3 AK3L1 AK6 AKL3L	Homo sapiens (Human)	227	FUNCTION: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. {ECO:0000255|HAMAP-Rule:MF_03169, ECO:0000269|PubMed:11485571}.		ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; blood coagulation [GO:0007596]; GTP metabolic process [GO:0046039]; ITP metabolic process [GO:0046041]; nucleoside triphosphate biosynthetic process [GO:0009142]; phosphorylation [GO:0016310]; UTP metabolic process [GO:0046051]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; nucleoside triphosphate adenylate kinase activity [GO:0046899]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; nucleoside triphosphate adenylate kinase activity [GO:0046899]; ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; blood coagulation [GO:0007596]; GTP metabolic process [GO:0046039]; ITP metabolic process [GO:0046041]; nucleoside triphosphate biosynthetic process [GO:0009142]; phosphorylation [GO:0016310]; UTP metabolic process [GO:0046051]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03169, ECO:0000269|PubMed:11485571}.
Q9UIK4	reviewed	DAPK2_HUMAN	Death-associated protein kinase 2 (DAP kinase 2) (EC 2.7.11.1) (DAP-kinase-related protein 1) (DRP-1)	DAPK2	Homo sapiens (Human)	370	FUNCTION: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). {ECO:0000269|PubMed:17347302, ECO:0000269|PubMed:24163421, ECO:0000269|PubMed:26047703}.; FUNCTION: Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.		anoikis [GO:0043276]; apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; positive regulation of eosinophil chemotaxis [GO:2000424]; positive regulation of neutrophil chemotaxis [GO:0090023]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]	autophagosome lumen [GO:0034423]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	autophagosome lumen [GO:0034423]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; anoikis [GO:0043276]; apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; positive regulation of eosinophil chemotaxis [GO:2000424]; positive regulation of neutrophil chemotaxis [GO:0090023]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle, autophagosome lumen.
Q9UIK5	reviewed	TEFF2_HUMAN	Tomoregulin-2 (TR-2) (Hyperplastic polyposis protein 1) (Transmembrane protein with EGF-like and two follistatin-like domains)	TMEFF2 HPP1 TENB2 TPEF UNQ178/PRO204	Homo sapiens (Human)	374	FUNCTION: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. {ECO:0000269|PubMed:10903839, ECO:0000269|PubMed:17942404}.		cell differentiation [GO:0030154]; negative regulation of cell migration [GO:0030336]; negative regulation of integrin biosynthetic process [GO:0045720]; negative regulation of stress fiber assembly [GO:0051497]; wound healing, spreading of cells [GO:0044319]	extracellular region [GO:0005576]; membrane [GO:0016020]		extracellular region [GO:0005576]; membrane [GO:0016020]; cell differentiation [GO:0030154]; negative regulation of cell migration [GO:0030336]; negative regulation of integrin biosynthetic process [GO:0045720]; negative regulation of stress fiber assembly [GO:0051497]; wound healing, spreading of cells [GO:0044319]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Q9UIL1	reviewed	SCOC_HUMAN	Short coiled-coil protein	SCOC SCOCO HRIHFB2072	Homo sapiens (Human)	159	FUNCTION: Positive regulator of amino acid starvation-induced autophagy. {ECO:0000269|PubMed:22354037}.		positive regulation of macroautophagy [GO:0016239]; regulation of protein complex stability [GO:0061635]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; positive regulation of macroautophagy [GO:0016239]; regulation of protein complex stability [GO:0061635]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11303027, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:24098481}; Peripheral membrane protein {ECO:0000269|PubMed:11303027, ECO:0000269|PubMed:24098481}; Cytoplasmic side {ECO:0000269|PubMed:11303027, ECO:0000269|PubMed:24098481}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:22354037}. Cytoplasm, cytosol {ECO:0000269|PubMed:11303027, ECO:0000269|PubMed:24098481}.
Q9UIL4	reviewed	KIF25_HUMAN	Kinesin-like protein KIF25 (Kinesin-like protein 3)	KIF25 KNSL3	Homo sapiens (Human)	384	FUNCTION: Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957). May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000250|UniProtKB:Q4R918, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:28263957}.		establishment of spindle orientation [GO:0051294]; microtubule-based movement [GO:0007018]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of autophagy [GO:0010507]; negative regulation of mitotic centrosome separation [GO:0046603]; nucleus localization [GO:0051647]; organelle organization [GO:0006996]; protein homotetramerization [GO:0051289]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]; establishment of spindle orientation [GO:0051294]; microtubule-based movement [GO:0007018]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of autophagy [GO:0010507]; negative regulation of mitotic centrosome separation [GO:0046603]; nucleus localization [GO:0051647]; organelle organization [GO:0006996]; protein homotetramerization [GO:0051289]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q4R918}.
Q9UIL8	reviewed	PHF11_HUMAN	PHD finger protein 11 (BRCA1 C-terminus-associated protein) (Renal carcinoma antigen NY-REN-34)	PHF11 BCAP	Homo sapiens (Human)	331	FUNCTION: Positive regulator of Th1-type cytokine gene expression. {ECO:0000269|PubMed:18405956}.			nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]	nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18405956}.
Q9UIQ6	reviewed	LCAP_HUMAN	Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form]	LNPEP OTASE	Homo sapiens (Human)	1025	FUNCTION: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}.		antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [GO:0002480]; cell-cell signaling [GO:0007267]; female pregnancy [GO:0007565]; negative regulation of cold-induced thermogenesis [GO:0120163]; peptide catabolic process [GO:0043171]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]	cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome lumen [GO:0031905]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome lumen [GO:0031905]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [GO:0002480]; cell-cell signaling [GO:0007267]; female pregnancy [GO:0007565]; negative regulation of cold-induced thermogenesis [GO:0120163]; peptide catabolic process [GO:0043171]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11389728}; Single-pass type II membrane protein {ECO:0000269|PubMed:11389728}. Note=In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.; SUBCELLULAR LOCATION: [Leucyl-cystinyl aminopeptidase, pregnancy serum form]: Secreted. Note=During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.
Q9UIR0	reviewed	BTNL2_HUMAN	Butyrophilin-like protein 2 (BTL-II)	BTNL2	Homo sapiens (Human)	455	FUNCTION: Negative regulator of T-cell proliferation. {ECO:0000250}.		regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; signaling receptor binding [GO:0005102]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15735647}; Single-pass type II membrane protein {ECO:0000269|PubMed:15735647}. Note=Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.
Q9UIS9	reviewed	MBD1_HUMAN	Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1)	MBD1 CXXC3 PCM1	Homo sapiens (Human)	605	FUNCTION: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}.		heart development [GO:0007507]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; neuron differentiation [GO:0030182]; regulation of DNA methylation [GO:0044030]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded methylated DNA binding [GO:0010385]; methyl-CpG binding [GO:0008327]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded methylated DNA binding [GO:0010385]; methyl-CpG binding [GO:0008327]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]; heart development [GO:0007507]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; neuron differentiation [GO:0030182]; regulation of DNA methylation [GO:0044030]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14610093}. Nucleus matrix {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624}. Nucleus speckle {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624}. Chromosome {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760}. Note=Nuclear, in a punctate pattern (PubMed:12711603). Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes (PubMed:10648624, PubMed:10454587). {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12711603}.
Q9UIU6	reviewed	SIX4_HUMAN	Homeobox protein SIX4 (Sine oculis homeobox homolog 4)	SIX4	Homo sapiens (Human)	781	FUNCTION: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis. {ECO:0000250|UniProtKB:Q61321}.		anatomical structure morphogenesis [GO:0009653]; embryonic cranial skeleton morphogenesis [GO:0048701]; fungiform papilla morphogenesis [GO:0061197]; generation of neurons [GO:0048699]; inner ear morphogenesis [GO:0042472]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; male sex differentiation [GO:0046661]; metanephric mesenchyme development [GO:0072075]; myoblast migration [GO:0051451]; myotome development [GO:0061055]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of satellite cell differentiation [GO:1902725]; olfactory placode formation [GO:0030910]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of epithelial cell proliferation [GO:0050678]; regulation of protein localization [GO:0032880]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of transcription by RNA polymerase II [GO:0006357]; sarcomere organization [GO:0045214]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; tongue development [GO:0043586]; trigeminal ganglion development [GO:0061551]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; embryonic cranial skeleton morphogenesis [GO:0048701]; fungiform papilla morphogenesis [GO:0061197]; generation of neurons [GO:0048699]; inner ear morphogenesis [GO:0042472]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; male sex differentiation [GO:0046661]; metanephric mesenchyme development [GO:0072075]; myoblast migration [GO:0051451]; myotome development [GO:0061055]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of satellite cell differentiation [GO:1902725]; olfactory placode formation [GO:0030910]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of epithelial cell proliferation [GO:0050678]; regulation of protein localization [GO:0032880]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of transcription by RNA polymerase II [GO:0006357]; sarcomere organization [GO:0045214]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; tongue development [GO:0043586]; trigeminal ganglion development [GO:0061551]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61321}. Cytoplasm {ECO:0000250|UniProtKB:Q61321}.
Q9UIV1	reviewed	CNOT7_HUMAN	CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a)	CNOT7 CAF1	Homo sapiens (Human)	285	FUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate (PubMed:20634287, PubMed:31439799, PubMed:19276069). Its function seems to be partially redundant with that of CNOT8 (PubMed:19605561). Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:20634287, PubMed:31439799, PubMed:19276069). During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation (PubMed:20065043). Additional complex functions may be a consequence of its influence on mRNA expression (PubMed:23236473, PubMed:19276069). Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity (PubMed:23236473, PubMed:19276069). {ECO:0000269|PubMed:19276069, ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:20634287, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:31439799}.		deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; defense response to virus [GO:0051607]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; P-body assembly [GO:0033962]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of viral genome replication [GO:0045070]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]; regulatory ncRNA-mediated gene silencing [GO:0031047]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]	3'-5'-RNA exonuclease activity [GO:0000175]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723]; RNA exonuclease activity [GO:0004532]; transcription corepressor activity [GO:0003714]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]; 3'-5'-RNA exonuclease activity [GO:0000175]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723]; RNA exonuclease activity [GO:0004532]; transcription corepressor activity [GO:0003714]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; defense response to virus [GO:0051607]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; P-body assembly [GO:0033962]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of viral genome replication [GO:0045070]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]; regulatory ncRNA-mediated gene silencing [GO:0031047]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9820826}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q60809}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:31439799}. Note=NANOS2 promotes its localization to P-body (By similarity). Recruited to cytoplasmic ribonucleoprotein membraneless compartments by CAPRIN1, promoting deadenylation of mRNAs (PubMed:31439799). {ECO:0000250|UniProtKB:Q60809, ECO:0000269|PubMed:31439799}.
Q9UIV8	reviewed	SPB13_HUMAN	Serpin B13 (HaCaT UV-repressible serpin) (Hurpin) (Headpin) (Peptidase inhibitor 13) (PI-13) (Proteinase inhibitor 13)	SERPINB13 PI13	Homo sapiens (Human)	391	FUNCTION: May play a role in the proliferation or differentiation of keratinocytes.		negative regulation of endopeptidase activity [GO:0010951]; negative regulation of keratinocyte apoptotic process [GO:1902173]; regulation of proteolysis [GO:0030162]; response to UV [GO:0009411]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of keratinocyte apoptotic process [GO:1902173]; regulation of proteolysis [GO:0030162]; response to UV [GO:0009411]	SUBCELLULAR LOCATION: Cytoplasm.
Q9UIW0	reviewed	VAX2_HUMAN	Ventral anterior homeobox 2	VAX2	Homo sapiens (Human)	290	FUNCTION: Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. {ECO:0000250}.		axonogenesis [GO:0007409]; brain development [GO:0007420]; central nervous system development [GO:0007417]; dorsal/ventral axis specification [GO:0009950]; ectoderm development [GO:0007398]; embryonic eye morphogenesis [GO:0048048]; forebrain development [GO:0030900]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; sequence-specific double-stranded DNA binding [GO:1990837]; axonogenesis [GO:0007409]; brain development [GO:0007420]; central nervous system development [GO:0007417]; dorsal/ventral axis specification [GO:0009950]; ectoderm development [GO:0007398]; embryonic eye morphogenesis [GO:0048048]; forebrain development [GO:0030900]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UIW2	reviewed	PLXA1_HUMAN	Plexin-A1 (Semaphorin receptor NOV)	PLXNA1 NOV PLXN1	Homo sapiens (Human)	1896	FUNCTION: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.		dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative regulation of cell adhesion [GO:0007162]; neuron projection extension [GO:1990138]; olfactory nerve formation [GO:0021628]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of smooth muscle cell migration [GO:0014910]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	semaphorin receptor activity [GO:0017154]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]; semaphorin receptor activity [GO:0017154]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative regulation of cell adhesion [GO:0007162]; neuron projection extension [GO:1990138]; olfactory nerve formation [GO:0021628]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of smooth muscle cell migration [GO:0014910]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000250}.
Q9UIX4	reviewed	KCNG1_HUMAN	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2)	KCNG1	Homo sapiens (Human)	513	FUNCTION: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135). {ECO:0000269|PubMed:19074135}.		potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of delayed rectifier potassium channel activity [GO:1902259]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; potassium channel activity [GO:0005267]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; potassium channel activity [GO:0005267]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of delayed rectifier potassium channel activity [GO:1902259]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19074135}; Multi-pass membrane protein {ECO:0000305}. Note=Colocalizes with KCNB1 at the plasma membrane (PubMed:19074135). {ECO:0000269|PubMed:19074135}.
Q9UJ14	reviewed	GGT7_HUMAN	Glutathione hydrolase 7 (EC 3.4.19.13) (Gamma-glutamyltransferase 7) (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltransferase-like 5) (Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathione hydrolase 7 light chain]	GGT7 GGTL3 GGTL5	Homo sapiens (Human)	662	FUNCTION: Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. {ECO:0000250|UniProtKB:P19440}.		glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]; negative regulation of response to oxidative stress [GO:1902883]	plasma membrane [GO:0005886]	glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]	plasma membrane [GO:0005886]; glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]; negative regulation of response to oxidative stress [GO:1902883]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P19440}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P07314}.
Q9UJ37	reviewed	SIA7B_HUMAN	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (EC 2.4.3.3) (GalNAc alpha-2,6-sialyltransferase II) (ST6GalNAc II) (ST6GalNAcII) (SThM) (Sialyltransferase 7B) (SIAT7-B)	ST6GALNAC2 SIAT7B SIATL1 STHM	Homo sapiens (Human)	374	FUNCTION: Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed:10742600, PubMed:29251719). Shows a preference for N-acetylgalactosamine (GalNAc) residues already modified by the addition of galactose or galactose followed by sialic acid in alpha-2,3 linkage (PubMed:10742600). {ECO:0000269|PubMed:10742600, ECO:0000269|PubMed:29251719}.	MISCELLANEOUS: Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN.	O-glycan processing [GO:0016266]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]; protein sialylation [GO:1990743]; viral protein processing [GO:0019082]	Golgi membrane [GO:0000139]	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; sialyltransferase activity [GO:0008373]	Golgi membrane [GO:0000139]; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; sialyltransferase activity [GO:0008373]; O-glycan processing [GO:0016266]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]; protein sialylation [GO:1990743]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9UJ41	reviewed	RABX5_HUMAN	Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5)	RABGEF1 RABEX5	Homo sapiens (Human)	491	FUNCTION: Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). {ECO:0000250, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:15339665, ECO:0000269|PubMed:9323142}.		dendritic transport [GO:0098935]; Kit signaling pathway [GO:0038109]; mast cell degranulation [GO:0043303]; mast cell migration [GO:0097531]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of Kit signaling pathway [GO:1900235]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of mast cell cytokine production [GO:0032764]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of receptor-mediated endocytosis [GO:0048261]; protein targeting to membrane [GO:0006612]; Ras protein signal transduction [GO:0007265]; receptor-mediated endocytosis [GO:0006898]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]	cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; nucleolus [GO:0005730]; recycling endosome [GO:0055037]	DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; nucleolus [GO:0005730]; recycling endosome [GO:0055037]; DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; dendritic transport [GO:0098935]; Kit signaling pathway [GO:0038109]; mast cell degranulation [GO:0043303]; mast cell migration [GO:0097531]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of Kit signaling pathway [GO:1900235]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of mast cell cytokine production [GO:0032764]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of receptor-mediated endocytosis [GO:0048261]; protein targeting to membrane [GO:0006612]; Ras protein signal transduction [GO:0007265]; receptor-mediated endocytosis [GO:0006898]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12505986}. Early endosome {ECO:0000269|PubMed:12505986}. Recycling endosome {ECO:0000269|PubMed:12505986}.
Q9UJ55	reviewed	MAGL2_HUMAN	MAGE-like protein 2 (Necdin-like protein 1) (Protein nM15)	MAGEL2 NDNL1	Homo sapiens (Human)	1249	FUNCTION: Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (PubMed:23452853). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (By similarity). {ECO:0000250|UniProtKB:Q9QZ04, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:23452853}.	MISCELLANEOUS: Imprinted, expressed from the paternal chromosome only.	Arp2/3 complex-mediated actin nucleation [GO:0034314]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of actin nucleation [GO:0051127]; protein K63-linked ubiquitination [GO:0070534]; regulation of circadian rhythm [GO:0042752]; retrograde transport, endosome to Golgi [GO:0042147]; rhythmic process [GO:0048511]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; nucleus [GO:0005634]	ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; nucleus [GO:0005634]; ubiquitin-protein transferase activity [GO:0004842]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of actin nucleation [GO:0051127]; protein K63-linked ubiquitination [GO:0070534]; regulation of circadian rhythm [GO:0042752]; retrograde transport, endosome to Golgi [GO:0042147]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:23452853}. Cytoplasm {ECO:0000250|UniProtKB:Q9QZ04}. Nucleus {ECO:0000250|UniProtKB:Q9QZ04}. Note=Recruited to retromer-containing endosomes via interaction with VPS35. Colocalizes with CLOCK and BMAL1 in the cytoplasm, and with PER2 in the cytoplasm and nucleus (By similarity). {ECO:0000250|UniProtKB:Q9QZ04, ECO:0000269|PubMed:23452853}.
Q9UJ68	reviewed	MSRA_HUMAN	Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR)	MSRA	Homo sapiens (Human)	235	FUNCTION: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	MISCELLANEOUS: [Isoform 1]: Mitochondrial. Produced by alternative splicing.; MISCELLANEOUS: [Isoform 2]: Cytoplasmic. Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Cytoplasmic and nuclear. Produced by alternative promoter usage. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Cytoplasmic. Produced by alternative initiation. {ECO:0000305}.	cellular response to oxidative stress [GO:0034599]; methionine metabolic process [GO:0006555]; protein modification process [GO:0036211]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	L-methionine-(S)-S-oxide reductase activity [GO:0036456]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; L-methionine-(S)-S-oxide reductase activity [GO:0036456]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113]; cellular response to oxidative stress [GO:0034599]; methionine metabolic process [GO:0006555]; protein modification process [GO:0036211]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Q9UJ70	reviewed	NAGK_HUMAN	N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60)	NAGK	Homo sapiens (Human)	344	FUNCTION: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:22692205). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575). {ECO:0000250|UniProtKB:Q9QZ08, ECO:0000269|PubMed:22692205, ECO:0000269|PubMed:36002575}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; N-acetylglucosamine metabolic process [GO:0006044]; N-acetylmannosamine metabolic process [GO:0006051]; N-acetylneuraminate catabolic process [GO:0019262]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; response to muramyl dipeptide [GO:0032495]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	ATP binding [GO:0005524]; muramyl dipeptide kinase activity [GO:0160047]; N-acetylglucosamine kinase activity [GO:0045127]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; muramyl dipeptide kinase activity [GO:0160047]; N-acetylglucosamine kinase activity [GO:0045127]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; N-acetylglucosamine metabolic process [GO:0006044]; N-acetylmannosamine metabolic process [GO:0006051]; N-acetylneuraminate catabolic process [GO:0019262]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; response to muramyl dipeptide [GO:0032495]	
Q9UJ71	reviewed	CLC4K_HUMAN	C-type lectin domain family 4 member K (Langerin) (CD antigen CD207)	CD207 CLEC4K	Homo sapiens (Human)	328	FUNCTION: Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:17334373, ECO:0000269|PubMed:20026605, ECO:0000269|PubMed:20097424}.		defense response to virus [GO:0051607]	clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; mannose binding [GO:0005537]	clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; mannose binding [GO:0005537]; defense response to virus [GO:0051607]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10661407}; Single-pass type II membrane protein {ECO:0000269|PubMed:10661407}. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Q9UJ78	reviewed	ZMYM5_HUMAN	Zinc finger MYM-type protein 5 (Zinc finger protein 198-like 1) (Zinc finger protein 237)	ZMYM5 ZNF198L1 ZNF237 HSPC050	Homo sapiens (Human)	669	FUNCTION: Functions as a transcriptional regulator. {ECO:0000269|PubMed:17126306}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	zinc ion binding [GO:0008270]	nucleus [GO:0005634]; zinc ion binding [GO:0008270]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UJ83	reviewed	HACL1_HUMAN	2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2)	HACL1 HPCL HPCL2 PHYH2 HSPC279	Homo sapiens (Human)	578	FUNCTION: Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:28289220, PubMed:21708296, PubMed:10468558). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:28289220, PubMed:21708296, PubMed:10468558). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). {ECO:0000250|UniProtKB:Q9QXE0, ECO:0000269|PubMed:10468558, ECO:0000269|PubMed:21708296, ECO:0000269|PubMed:28289220}.		fatty acid alpha-oxidation [GO:0001561]; fatty acid metabolic process [GO:0006631]; methyl-branched fatty acid metabolic process [GO:0097089]; phytanic acid metabolic process [GO:1903512]; protein targeting to peroxisome [GO:0006625]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	2-hydroxyacyl-CoA lyase activity [GO:0106359]; 2-hydroxyphytanoyl-CoA lyase activity [GO:0106376]; ATP binding [GO:0005524]; carbon-carbon lyase activity [GO:0016830]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; 2-hydroxyacyl-CoA lyase activity [GO:0106359]; 2-hydroxyphytanoyl-CoA lyase activity [GO:0106376]; ATP binding [GO:0005524]; carbon-carbon lyase activity [GO:0016830]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976]; fatty acid alpha-oxidation [GO:0001561]; fatty acid metabolic process [GO:0006631]; methyl-branched fatty acid metabolic process [GO:0097089]; phytanic acid metabolic process [GO:1903512]; protein targeting to peroxisome [GO:0006625]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:10468558, ECO:0000269|PubMed:21708296, ECO:0000269|PubMed:28289220}.
Q9UJ90	reviewed	KCNE5_HUMAN	Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (AMME syndrome candidate gene 2 protein) (Potassium channel subunit beta MiRP4) (Potassium voltage-gated channel subfamily E member 1-like protein)	KCNE5 AMMECR2 KCNE1L	Homo sapiens (Human)	142	FUNCTION: Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. {ECO:0000269|PubMed:12324418}.		atrial cardiac muscle cell action potential [GO:0086014]; cardiac muscle contraction [GO:0060048]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of potassium ion export across plasma membrane [GO:1903765]; negative regulation of potassium ion transmembrane transport [GO:1901380]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export across plasma membrane [GO:0097623]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of cation channel activity [GO:2001257]; regulation of heart contraction [GO:0008016]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; atrial cardiac muscle cell action potential [GO:0086014]; cardiac muscle contraction [GO:0060048]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of potassium ion export across plasma membrane [GO:1903765]; negative regulation of potassium ion transmembrane transport [GO:1901380]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export across plasma membrane [GO:0097623]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of cation channel activity [GO:2001257]; regulation of heart contraction [GO:0008016]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:20533308}; Single-pass type I membrane protein {ECO:0000305}.
Q9UJ96	reviewed	KCNG2_HUMAN	Potassium voltage-gated channel subfamily G member 2 (Cardiac potassium channel subunit) (Voltage-gated potassium channel subunit Kv6.2)	KCNG2 KCNF2	Homo sapiens (Human)	466	FUNCTION: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.	MISCELLANEOUS: Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone.	potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of heart contraction [GO:0008016]; regulation of monoatomic ion transmembrane transport [GO:0034765]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated potassium channel activity [GO:0005249]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of heart contraction [GO:0008016]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9UJ98	reviewed	STAG3_HUMAN	Cohesin subunit SA-3 (SCC3 homolog 3) (Stromal antigen 3) (Stromalin-3)	STAG3	Homo sapiens (Human)	1225	FUNCTION: Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. {ECO:0000269|PubMed:31682730}.		establishment of meiotic sister chromatid cohesion [GO:0034089]; sister chromatid cohesion [GO:0007062]; synaptonemal complex assembly [GO:0007130]	chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; extracellular space [GO:0005615]; meiotic cohesin complex [GO:0030893]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]	chromatin binding [GO:0003682]	chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; extracellular space [GO:0005615]; meiotic cohesin complex [GO:0030893]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]; chromatin binding [GO:0003682]; establishment of meiotic sister chromatid cohesion [GO:0034089]; sister chromatid cohesion [GO:0007062]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750, ECO:0000269|PubMed:12034751}. Chromosome {ECO:0000269|PubMed:12034751}. Chromosome, centromere {ECO:0000269|PubMed:12034751}. Note=Associates with chromatin. In prophase I stage of meiosis, it is found along the axial elements of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. It however remains chromatin associated at the centromeres up to metaphase I. During anaphase I, it probably dissociates from centromeres, allowing chromosomes segregation. {ECO:0000269|PubMed:12034751}.
Q9UJA2	reviewed	CRLS1_HUMAN	Cardiolipin synthase (CMP-forming) (CLS) (EC 2.7.8.41) (Protein GCD10 homolog)	CRLS1 C20orf155 CLS1	Homo sapiens (Human)	301	FUNCTION: Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. {ECO:0000269|PubMed:16547353, ECO:0000269|PubMed:16678169, ECO:0000269|PubMed:35147173}.		cardiolipin biosynthetic process [GO:0032049]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; response to phosphatidylethanolamine [GO:1905711]; response to thyroxine [GO:0097068]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; cardiolipin synthase (CMP-forming) [GO:0043337]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; cardiolipin synthase (CMP-forming) [GO:0043337]; cardiolipin biosynthetic process [GO:0032049]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; response to phosphatidylethanolamine [GO:1905711]; response to thyroxine [GO:0097068]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16547353}; Multi-pass membrane protein {ECO:0000269|PubMed:16547353}.
Q9UJA3	reviewed	MCM8_HUMAN	DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8)	MCM8 C20orf154	Homo sapiens (Human)	840	FUNCTION: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093). {ECO:0000250|UniProtKB:Q9CWV1, ECO:0000269|PubMed:15684404, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093}.	MISCELLANEOUS: [Isoform 3]: No experimental confirmation available. According to PubMed:12771218, this isoform could be derived from an aberrant mRNA form found in placental choriocarcinoma.	cell cycle [GO:0007049]; DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; double-strand break repair via homologous recombination [GO:0000724]; female gamete generation [GO:0007292]; male gamete generation [GO:0048232]; mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication [GO:0070716]; protein localization to chromatin [GO:0071168]; protein stabilization [GO:0050821]; recombinational interstrand cross-link repair [GO:0036298]	chromosome [GO:0005694]; MCM complex [GO:0042555]; MCM8-MCM9 complex [GO:0097362]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; helicase activity [GO:0004386]; MutLbeta complex binding [GO:0032406]; MutSalpha complex binding [GO:0032407]; MutSbeta complex binding [GO:0032408]; single-stranded DNA binding [GO:0003697]	chromosome [GO:0005694]; MCM complex [GO:0042555]; MCM8-MCM9 complex [GO:0097362]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; helicase activity [GO:0004386]; MutLbeta complex binding [GO:0032406]; MutSalpha complex binding [GO:0032407]; MutSbeta complex binding [GO:0032408]; single-stranded DNA binding [GO:0003697]; cell cycle [GO:0007049]; DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; double-strand break repair via homologous recombination [GO:0000724]; female gamete generation [GO:0007292]; male gamete generation [GO:0048232]; mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication [GO:0070716]; protein localization to chromatin [GO:0071168]; protein stabilization [GO:0050821]; recombinational interstrand cross-link repair [GO:0036298]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12527764, ECO:0000269|PubMed:18072282, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. Chromosome {ECO:0000269|PubMed:15684404, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093}. Note=Localizes to nuclear foci (PubMed:26215093). Localizes to double-stranded DNA breaks (PubMed:23401855). Binds chromatin throughout the cell cycle (PubMed:15684404). {ECO:0000269|PubMed:15684404, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093}.
Q9UJA5	reviewed	TRM6_HUMAN	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6)	TRMT6 KIAA1153 TRM6 CGI-09	Homo sapiens (Human)	497	FUNCTION: Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297). {ECO:0000269|PubMed:16043508, ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537}.		mRNA methylation [GO:0080009]; tRNA methylation [GO:0030488]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515]; RNA binding [GO:0003723]; mRNA methylation [GO:0080009]; tRNA methylation [GO:0030488]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P41814}.
Q9UJA9	reviewed	ENPP5_HUMAN	Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5) (EC 3.1.-.-)	ENPP5 UNQ550/PRO1107	Homo sapiens (Human)	477	FUNCTION: Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication. {ECO:0000250|UniProtKB:P84039, ECO:0000250|UniProtKB:Q9EQG7}.		cell communication [GO:0007154]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	NAD+ diphosphatase activity [GO:0000210]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; NAD+ diphosphatase activity [GO:0000210]; zinc ion binding [GO:0008270]; cell communication [GO:0007154]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9UJC3	reviewed	HOOK1_HUMAN	Protein Hook homolog 1 (h-hook1) (hHK1)	HOOK1	Homo sapiens (Human)	728	FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). {ECO:0000250|UniProtKB:Q8BIL5, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}.		cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; Golgi organization [GO:0007030]; lysosome organization [GO:0007040]; manchette assembly [GO:1905198]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FHF complex [GO:0070695]; microtubule [GO:0005874]	actin binding [GO:0003779]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FHF complex [GO:0070695]; microtubule [GO:0005874]; actin binding [GO:0003779]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; Golgi organization [GO:0007030]; lysosome organization [GO:0007040]; manchette assembly [GO:1905198]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15471887}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11238449}. Note=Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosomes, or mitochondria (By similarity). Often found in close association with microtubules (By similarity). Does not associate with the Golgi complex. During spermiogenesis, it localizes to the manchette in spermatids from steps 8-10. It is also present between the microtubule manchette and the nucleus. During manchette elongation, it is preferentially localized to the nuclear ring of the manchette, whereas the strong localization to the manchette decreases. In more mature spermatids, while the manchette migrates posteriorly, it localizes to punctuates spots. At later stages of spermatid differentiation, the punctuate expression pattern is found at both the attachment site and the proximal end of the elongated manchette. In contrast, it is not present in mature spermatozoa (By similarity). {ECO:0000250|UniProtKB:Q8BIL5}.
Q9UJD0	reviewed	RIMS3_HUMAN	Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3)	RIMS3 KIAA0237	Homo sapiens (Human)	308	FUNCTION: Regulates synaptic membrane exocytosis. {ECO:0000250}.		calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-ion regulated exocytosis [GO:0017156]; positive regulation of synaptic transmission [GO:0050806]; regulation of membrane potential [GO:0042391]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300]	cytoskeleton of presynaptic active zone [GO:0048788]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]	small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]	cytoskeleton of presynaptic active zone [GO:0048788]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-ion regulated exocytosis [GO:0017156]; positive regulation of synaptic transmission [GO:0050806]; regulation of membrane potential [GO:0042391]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300]	SUBCELLULAR LOCATION: Synapse {ECO:0000250}.
Q9UJF2	reviewed	NGAP_HUMAN	Ras GTPase-activating protein nGAP (RAS protein activator-like 2)	RASAL2 NGAP	Homo sapiens (Human)	1139	FUNCTION: Inhibitory regulator of the Ras-cyclic AMP pathway.		adipose tissue development [GO:0060612]; gene expression [GO:0010467]; multicellular organism growth [GO:0035264]; regulation of protein activation cascade [GO:2000257]; response to dietary excess [GO:0002021]; response to glucose [GO:0009749]; signal transduction [GO:0007165]	cytosol [GO:0005829]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; adipose tissue development [GO:0060612]; gene expression [GO:0010467]; multicellular organism growth [GO:0035264]; regulation of protein activation cascade [GO:2000257]; response to dietary excess [GO:0002021]; response to glucose [GO:0009749]; signal transduction [GO:0007165]	
Q9UJJ9	reviewed	GNPTG_HUMAN	N-acetylglucosamine-1-phosphotransferase subunit gamma (GlcNAc-1-phosphotransferase subunit gamma) (UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma)	GNPTG C16orf27 GNPTAG CAB56184 LP2537	Homo sapiens (Human)	305	FUNCTION: Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors. {ECO:0000269|PubMed:10712439, ECO:0000269|PubMed:19955174}.		carbohydrate phosphorylation [GO:0046835]; N-glycan processing to lysosome [GO:0016256]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex [GO:0070622]	protein homodimerization activity [GO:0042803]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex [GO:0070622]; protein homodimerization activity [GO:0042803]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976]; carbohydrate phosphorylation [GO:0046835]; N-glycan processing to lysosome [GO:0016256]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15532026}. Golgi apparatus {ECO:0000269|PubMed:15532026, ECO:0000269|PubMed:26108976, ECO:0000269|PubMed:27038293}.
Q9UJL9	reviewed	ZF69B_HUMAN	Zinc finger protein 69 homolog B (Zinc finger protein 643)	ZFP69B ZNF643	Homo sapiens (Human)	534	FUNCTION: May be involved in transcriptional regulation. Essential for Golgi structural integrity (PubMed:29851555). {ECO:0000269|PubMed:29851555}.		Golgi organization [GO:0007030]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleolus [GO:0005730]; nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; Golgi organization [GO:0007030]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29851555}.
Q9UJM3	reviewed	ERRFI_HUMAN	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6)	ERRFI1 MIG6	Homo sapiens (Human)	462	FUNCTION: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}.		lung alveolus development [GO:0048286]; lung epithelium development [GO:0060428]; lung vasculature development [GO:0060426]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of protein autophosphorylation [GO:0031953]; regulation of keratinocyte differentiation [GO:0045616]; skin morphogenesis [GO:0043589]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; protein kinase binding [GO:0019901]; lung alveolus development [GO:0048286]; lung epithelium development [GO:0060428]; lung vasculature development [GO:0060426]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of protein autophosphorylation [GO:0031953]; regulation of keratinocyte differentiation [GO:0045616]; skin morphogenesis [GO:0043589]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7641805}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity). {ECO:0000250}.
Q9UJM8	reviewed	HAOX1_HUMAN	2-Hydroxyacid oxidase 1 (HAOX1) (EC 1.1.3.15) (Glycolate oxidase) (GO) (GOX) (Glyoxylate oxidase) (EC 1.2.3.5)	HAO1 GOX1	Homo sapiens (Human)	370	FUNCTION: Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate (PubMed:10777549, PubMed:17669354, PubMed:18215067, PubMed:10978532). The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones (PubMed:10978532, PubMed:17669354). Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency (PubMed:10777549, PubMed:17669354, PubMed:18215067). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2 (PubMed:10777549, PubMed:17669354, PubMed:18215067, PubMed:10978532). Is not active on L-lactate and 2-hydroxybutanoate (PubMed:10777549). {ECO:0000269|PubMed:10777549, ECO:0000269|PubMed:10978532, ECO:0000269|PubMed:17669354, ECO:0000269|PubMed:18215067, ECO:0000303|PubMed:10978532, ECO:0000303|PubMed:17669354}.		fatty acid alpha-oxidation [GO:0001561]; glycine biosynthetic process [GO:0006545]; glycolate catabolic process [GO:0046296]; response to oxidative stress [GO:0006979]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	(S)-2-hydroxy-acid oxidase activity [GO:0003973]; FMN binding [GO:0010181]; glyoxylate oxidase activity [GO:0047969]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; (S)-2-hydroxy-acid oxidase activity [GO:0003973]; FMN binding [GO:0010181]; glyoxylate oxidase activity [GO:0047969]; fatty acid alpha-oxidation [GO:0001561]; glycine biosynthetic process [GO:0006545]; glycolate catabolic process [GO:0046296]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000269|PubMed:10777549}.
Q9UJP4	reviewed	KLH21_HUMAN	Kelch-like protein 21	KLHL21 KIAA0469	Homo sapiens (Human)	597	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:19995937}.		cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome passenger complex localization to spindle midzone [GO:0035853]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; polar microtubule [GO:0005827]	cullin family protein binding [GO:0097602]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; polar microtubule [GO:0005827]; cullin family protein binding [GO:0097602]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome passenger complex localization to spindle midzone [GO:0035853]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19995937}. Note=Localizes to the spindle midzone and targets CUL3 to this region.
Q9UJQ1	reviewed	LAMP5_HUMAN	Lysosome-associated membrane glycoprotein 5 (Brain and dendritic cell-associated LAMP) (Brain-associated LAMP-like protein) (BAD-LAMP) (Lysosome-associated membrane protein 5) (LAMP-5)	LAMP5 C20orf103	Homo sapiens (Human)	280	FUNCTION: Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. {ECO:0000250|UniProtKB:Q9D387}.	MISCELLANEOUS: Appears to be a novel specific biomarker for blastic plasmocytoid dendritic cells neoplasia. {ECO:0000305|PubMed:21642595}.	establishment of protein localization to organelle [GO:0072594]	cytoplasmic vesicle membrane [GO:0030659]; dendrite membrane [GO:0032590]; early endosome membrane [GO:0031901]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome membrane [GO:0010008]; growth cone membrane [GO:0032584]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle membrane [GO:0030672]		cytoplasmic vesicle membrane [GO:0030659]; dendrite membrane [GO:0032590]; early endosome membrane [GO:0031901]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome membrane [GO:0010008]; growth cone membrane [GO:0032584]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle membrane [GO:0030672]; establishment of protein localization to organelle [GO:0072594]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21642595}; Single-pass type I membrane protein {ECO:0000269|PubMed:21642595}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:21642595}; Single-pass type I membrane protein {ECO:0000269|PubMed:21642595}. Endosome membrane {ECO:0000269|PubMed:21642595}; Single-pass type I membrane protein {ECO:0000269|PubMed:21642595}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9D387}. Cell projection, growth cone membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein {ECO:0000305}. Recycling endosome {ECO:0000250|UniProtKB:Q9D387}. Note=Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity). Colocalizes with UNC93B1 in large endosomal intracellular vesicles (PubMed:21642595). Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides (PubMed:21642595). Associates with cortical membranes (PubMed:21642595). Localizes mostly in cytoplasmic vesicles of neuronal cell body (By similarity). Localizes to synaptic vesicles in a subset of GABAergic neurons (By similarity). {ECO:0000250|UniProtKB:Q9D387, ECO:0000269|PubMed:21642595}.
Q9UJQ4	reviewed	SALL4_HUMAN	Sal-like protein 4 (Zinc finger protein 797) (Zinc finger protein SALL4)	SALL4 ZNF797	Homo sapiens (Human)	1053	FUNCTION: Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells. {ECO:0000269|PubMed:23012367}.		embryonic limb morphogenesis [GO:0030326]; inner cell mass cell proliferation [GO:0001833]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; ventricular septum development [GO:0003281]	cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; embryonic limb morphogenesis [GO:0030326]; inner cell mass cell proliferation [GO:0001833]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q9UJS0	reviewed	S2513_HUMAN	Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (Calcium-binding mitochondrial carrier protein Aralar2) (ARALAR-related gene 2) (ARALAR2) (Citrin) (Mitochondrial aspartate glutamate carrier 2) (Solute carrier family 25 member 13)	SLC25A13	Homo sapiens (Human)	675	FUNCTION: Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871). Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). {ECO:0000269|PubMed:11566871}.		aspartate family amino acid metabolic process [GO:0009066]; aspartate transmembrane transport [GO:0015810]; ATP biosynthetic process [GO:0006754]; cellular respiration [GO:0045333]; gluconeogenesis [GO:0006094]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; mitochondrial transport [GO:0006839]; response to calcium ion [GO:0051592]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	3-sulfino-L-alanine: proton, glutamate antiporter activity [GO:0000514]; acidic amino acid transmembrane transporter activity [GO:0015172]; aspartate:glutamate, proton antiporter activity [GO:0000515]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; 3-sulfino-L-alanine: proton, glutamate antiporter activity [GO:0000514]; acidic amino acid transmembrane transporter activity [GO:0015172]; aspartate:glutamate, proton antiporter activity [GO:0000515]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; aspartate family amino acid metabolic process [GO:0009066]; aspartate transmembrane transport [GO:0015810]; ATP biosynthetic process [GO:0006754]; cellular respiration [GO:0045333]; gluconeogenesis [GO:0006094]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; mitochondrial transport [GO:0006839]; response to calcium ion [GO:0051592]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:10642534, ECO:0000269|PubMed:11566871}; Multi-pass membrane protein {ECO:0000269|PubMed:11566871}.
Q9UJT1	reviewed	TBD_HUMAN	Tubulin delta chain (Delta-tubulin)	TUBD1 TUBD	Homo sapiens (Human)	453	FUNCTION: Acts as a positive regulator of hedgehog signaling and regulates ciliary function. {ECO:0000250|UniProtKB:Q9R1K7}.		cell projection organization [GO:0030030]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; positive regulation of smoothened signaling pathway [GO:0045880]	centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]	GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200]	centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200]; cell projection organization [GO:0030030]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; positive regulation of smoothened signaling pathway [GO:0045880]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9R1K7}. Cytoplasm {ECO:0000250|UniProtKB:Q9R1K7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9R1K7}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9R1K7}. Note=Associated with centrioles. Both cytoplasmic and nuclear. In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head. {ECO:0000250|UniProtKB:Q9R1K7}.
Q9UJT2	reviewed	TSKS_HUMAN	Testis-specific serine kinase substrate (Testis-specific kinase substrate) (STK22 substrate 1)	TSKS STK22S1 TSKS1	Homo sapiens (Human)	592	FUNCTION: May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.			centriole [GO:0005814]; cytoplasm [GO:0005737]	protein kinase binding [GO:0019901]	centriole [GO:0005814]; cytoplasm [GO:0005737]; protein kinase binding [GO:0019901]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:18495105}. Note=Concentrates in spermatid centrioles during flagellogenesis.
Q9UJT9	reviewed	FBXL7_HUMAN	F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7)	FBXL7 FBL6 FBL7 KIAA0840	Homo sapiens (Human)	491	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:25778398). During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By similarity). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398, PubMed:28218735). {ECO:0000250|UniProtKB:Q5BJ29, ECO:0000269|PubMed:25778398, ECO:0000269|PubMed:28218735}.		cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]	centrosome [GO:0005813]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]		centrosome [GO:0005813]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5BJ29}. Note=Localizes to the centrosome during spindle formation. {ECO:0000250|UniProtKB:Q5BJ29}.
Q9UJU2	reviewed	LEF1_HUMAN	Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha)	LEF1	Homo sapiens (Human)	399	FUNCTION: Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540). Regulates T-cell receptor alpha enhancer function (PubMed:19653274). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:P27782, ECO:0000269|PubMed:11266540, ECO:0000269|PubMed:19653274, ECO:0000269|PubMed:2010090}.; FUNCTION: [Isoform 1]: Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. {ECO:0000269|PubMed:19653274}.; FUNCTION: [Isoform 3]: Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling. {ECO:0000269|PubMed:11326276}.; FUNCTION: [Isoform 5]: Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. {ECO:0000269|PubMed:19653274}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing of isoform 1. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage. Acts as dominant negative mutant. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 3. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Produced by alternative splicing of isoform 1. {ECO:0000305}.	anatomical structure regression [GO:0060033]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; B cell proliferation [GO:0042100]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; canonical Wnt signaling pathway [GO:0060070]; cell chemotaxis [GO:0060326]; cellular response to cytokine stimulus [GO:0071345]; cellular response to interleukin-4 [GO:0071353]; chorio-allantoic fusion [GO:0060710]; dentate gyrus development [GO:0021542]; embryonic limb morphogenesis [GO:0030326]; epithelial cell apoptotic process [GO:1904019]; epithelial to mesenchymal transition [GO:0001837]; face morphogenesis [GO:0060325]; forebrain neuroblast division [GO:0021873]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; mammary gland development [GO:0030879]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process in bone marrow cell [GO:0071866]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neutrophil differentiation [GO:0030223]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; paraxial mesoderm formation [GO:0048341]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell cycle process [GO:0090068]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; protein localization to chromatin [GO:0071168]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; secondary palate development [GO:0062009]; sensory perception of taste [GO:0050909]; somitogenesis [GO:0001756]; sprouting angiogenesis [GO:0002040]; T cell receptor V(D)J recombination [GO:0033153]; T-helper 1 cell differentiation [GO:0045063]; tongue development [GO:0043586]; trachea gland development [GO:0061153]; transcription by RNA polymerase II [GO:0006366]	beta-catenin-TCF complex [GO:1990907]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]	armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; gamma-catenin binding [GO:0045295]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]; transcription regulator inhibitor activity [GO:0140416]	beta-catenin-TCF complex [GO:1990907]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]; armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; gamma-catenin binding [GO:0045295]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]; transcription regulator inhibitor activity [GO:0140416]; anatomical structure regression [GO:0060033]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; B cell proliferation [GO:0042100]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; canonical Wnt signaling pathway [GO:0060070]; cell chemotaxis [GO:0060326]; cellular response to cytokine stimulus [GO:0071345]; cellular response to interleukin-4 [GO:0071353]; chorio-allantoic fusion [GO:0060710]; dentate gyrus development [GO:0021542]; embryonic limb morphogenesis [GO:0030326]; epithelial cell apoptotic process [GO:1904019]; epithelial to mesenchymal transition [GO:0001837]; face morphogenesis [GO:0060325]; forebrain neuroblast division [GO:0021873]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; mammary gland development [GO:0030879]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process in bone marrow cell [GO:0071866]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neutrophil differentiation [GO:0030223]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; paraxial mesoderm formation [GO:0048341]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell cycle process [GO:0090068]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; protein localization to chromatin [GO:0071168]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; secondary palate development [GO:0062009]; sensory perception of taste [GO:0050909]; somitogenesis [GO:0001756]; sprouting angiogenesis [GO:0002040]; T cell receptor V(D)J recombination [GO:0033153]; T-helper 1 cell differentiation [GO:0045063]; tongue development [GO:0043586]; trachea gland development [GO:0061153]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Note=Found in nuclear bodies upon PIASG binding. {ECO:0000250}.
Q9UJU5	reviewed	FOXD3_HUMAN	Forkhead box protein D3 (HNF3/FH transcription factor genesis)	FOXD3 HFH2	Homo sapiens (Human)	478	FUNCTION: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor (PubMed:11891324). Also acts as a transcriptional activator (PubMed:11891324). Negatively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). Promotes development of neural crest cells from neural tube progenitors (PubMed:11891324). Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation (PubMed:11891324). Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (PubMed:11891324). {ECO:0000269|PubMed:11891324, ECO:0000269|PubMed:22306510}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; in utero embryonic development [GO:0001701]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; in utero embryonic development [GO:0001701]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UJU6	reviewed	DBNL_HUMAN	Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7)	DBNL CMAP SH3P7 PP5423	Homo sapiens (Human)	430	FUNCTION: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}.		adaptive immune response [GO:0002250]; endocytosis [GO:0006897]; membrane organization [GO:0061024]; neuron projection morphogenesis [GO:0048812]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; synapse assembly [GO:0007416]	anchoring junction [GO:0070161]; cell cortex [GO:0005938]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; enzyme activator activity [GO:0008047]; protein domain specific binding [GO:0019904]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]	anchoring junction [GO:0070161]; cell cortex [GO:0005938]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; enzyme activator activity [GO:0008047]; protein domain specific binding [GO:0019904]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; adaptive immune response [GO:0002250]; endocytosis [GO:0006897]; membrane organization [GO:0061024]; neuron projection morphogenesis [GO:0048812]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q62418}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q62418}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q62418}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q62418}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JHL4}. Synapse {ECO:0000250|UniProtKB:Q62418}. Perikaryon {ECO:0000250|UniProtKB:Q62418}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q62418}. Cell membrane {ECO:0000269|PubMed:14729663}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62418}; Cytoplasmic side {ECO:0000250|UniProtKB:Q62418}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q62418}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62418}; Cytoplasmic side {ECO:0000250|UniProtKB:Q62418}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q62418}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62418}; Cytoplasmic side {ECO:0000250|UniProtKB:Q62418}. Cell projection, podosome {ECO:0000250|UniProtKB:Q62418}. Early endosome {ECO:0000269|PubMed:14729663}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JHL4}. Postsynaptic density {ECO:0000250|UniProtKB:Q9JHL4}. Note=Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes. {ECO:0000250|UniProtKB:Q62418, ECO:0000250|UniProtKB:Q9JHL4}.
Q9UJV3	reviewed	TRIM1_HUMAN	Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1)	MID2 FXY2 RNF60 TRIM1	Homo sapiens (Human)	735	FUNCTION: E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29 (PubMed:35266954). {ECO:0000269|PubMed:35266954, ECO:0000303|PubMed:24115387}.		innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein localization to microtubule [GO:0035372]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein localization to microtubule [GO:0035372]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:35266954}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:35266954}. Note=Microtubule-associated. {ECO:0000269|PubMed:35266954}.
Q9UJV9	reviewed	DDX41_HUMAN	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog)	DDX41 ABS	Homo sapiens (Human)	622	FUNCTION: Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:25920683}.		apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26712909}.
Q9UJW0	reviewed	DCTN4_HUMAN	Dynactin subunit 4 (Dyn4) (Dynactin subunit p62)	DCTN4	Homo sapiens (Human)	460	FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:A0A4X1TB62}.			cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; focal adhesion [GO:0005925]; kinetochore [GO:0000776]; nucleus [GO:0005634]; sarcomere [GO:0030017]; spindle pole [GO:0000922]; stress fiber [GO:0001725]		cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; focal adhesion [GO:0005925]; kinetochore [GO:0000776]; nucleus [GO:0005634]; sarcomere [GO:0030017]; spindle pole [GO:0000922]; stress fiber [GO:0001725]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10671518}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10671518}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q9QUR2}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9QUR2}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q8CBY8}. Note=Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (PubMed:10671518). Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (By similarity). In skeletal muscles, costamere localization requires the presence of ANK2 (By similarity). {ECO:0000250|UniProtKB:Q8CBY8, ECO:0000250|UniProtKB:Q9QUR2, ECO:0000269|PubMed:10671518}.
Q9UJW2	reviewed	TINAG_HUMAN	Tubulointerstitial nephritis antigen (TIN-Ag)	TINAG	Homo sapiens (Human)	476	FUNCTION: Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein. {ECO:0000269|PubMed:8770961}.	MISCELLANEOUS: Antibodies against TINAG are found in sera of patients with tubulointerstitial nephritis, a rare autoimmune disorder that causes acute and chronic renal injury.; MISCELLANEOUS: [Isoform 1]: Major isoform.	cell adhesion [GO:0007155]; proteolysis [GO:0006508]	basement membrane [GO:0005604]; extracellular space [GO:0005615]	cysteine-type endopeptidase activity [GO:0004197]; nucleotide binding [GO:0000166]	basement membrane [GO:0005604]; extracellular space [GO:0005615]; cysteine-type endopeptidase activity [GO:0004197]; nucleotide binding [GO:0000166]; cell adhesion [GO:0007155]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:10752525, ECO:0000269|PubMed:1762287}.
Q9UJW3	reviewed	DNM3L_HUMAN	DNA (cytosine-5)-methyltransferase 3-like	DNMT3L	Homo sapiens (Human)	386	FUNCTION: Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327). Plays a key role in embryonic stem cells and germ cells (By similarity). In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity). Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (By similarity). While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity). Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity). {ECO:0000250|UniProtKB:Q9CWR8, ECO:0000269|PubMed:17687327}.	MISCELLANEOUS: Interaction with histone H3 is strongly inhibited by methylation at lysine 4 (H3K4me).	C-5 methylation of cytosine [GO:0090116]; chorionic trophoblast cell differentiation [GO:0060718]; DNA methylation [GO:0006306]; DNA methylation on cytosine [GO:0032776]; genomic imprinting [GO:0071514]; in utero embryonic development [GO:0001701]; male meiosis I [GO:0007141]; negative regulation of DNA methylation [GO:1905642]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; placenta development [GO:0001890]; positive regulation of DNA methylation [GO:1905643]; regulation of gene expression by genomic imprinting [GO:0006349]; retrotransposon silencing by heterochromatin formation [GO:0141005]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]	catalytic complex [GO:1902494]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; heterochromatin [GO:0000792]; nucleus [GO:0005634]	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [GO:0051718]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]	catalytic complex [GO:1902494]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [GO:0051718]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; C-5 methylation of cytosine [GO:0090116]; chorionic trophoblast cell differentiation [GO:0060718]; DNA methylation [GO:0006306]; DNA methylation on cytosine [GO:0032776]; genomic imprinting [GO:0071514]; in utero embryonic development [GO:0001701]; male meiosis I [GO:0007141]; negative regulation of DNA methylation [GO:1905642]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; placenta development [GO:0001890]; positive regulation of DNA methylation [GO:1905643]; regulation of gene expression by genomic imprinting [GO:0006349]; retrotransposon silencing by heterochromatin formation [GO:0141005]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UJW8	reviewed	ZN180_HUMAN	Zinc finger protein 180 (HHZ168)	ZNF180	Homo sapiens (Human)	692	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UJW9	reviewed	SRTD3_HUMAN	SERTA domain-containing protein 3 (Replication protein-binding trans-activator) (RPA-binding trans-activator)	SERTAD3 RBT1	Homo sapiens (Human)	196	FUNCTION: Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms (PubMed:33147462, PubMed:36594413). Plays a role in the late phase response of TLR-induced immune effector expression (By similarity). During influenza infection, interacts with PB2, PB1, and PA to disrupt the formation of the viral RdRp complex (PubMed:33147462). Inhibits zika virus by interacting with the capsid protein in the nucleolus and reducing its abundance through proteasomal degradation (PubMed:36594413). Strong transcriptional coactivator (PubMed:10982866). {ECO:0000250|UniProtKB:Q9ERC3, ECO:0000269|PubMed:10982866, ECO:0000269|PubMed:33147462, ECO:0000269|PubMed:36594413}.		negative regulation of cell growth [GO:0030308]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of cell growth [GO:0030308]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10982866}.
Q9UJX0	reviewed	OSGI1_HUMAN	Oxidative stress-induced growth inhibitor 1 (Bone marrow stromal cell-derived growth inhibitor) (BMSC-derived growth inhibitor) (Ovary, kidney and liver protein 38) (huOKL38) (Pregnancy-induced growth inhibitor OKL38)	OSGIN1 BDGI OKL38	Homo sapiens (Human)	477	FUNCTION: Regulates the differentiation and proliferation through the regulation of cell death. {ECO:0000269|PubMed:11459809, ECO:0000269|PubMed:14570898, ECO:0000269|PubMed:15569677}.	MISCELLANEOUS: Loss of OSGIN1 protein disturbs the balance between cell growth, differentiation, and cell death in normal tissue, resulting in uncontrolled growth and formation of tumors.	cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]		growth factor activity [GO:0008083]	growth factor activity [GO:0008083]; cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]	
Q9UJX2	reviewed	CDC23_HUMAN	Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8)	CDC23 ANAPC8	Homo sapiens (Human)	597	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; regulation of exit from mitosis [GO:0007096]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ubiquitin-dependent protein catabolic process [GO:0006511]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	ubiquitin-protein transferase activity [GO:0004842]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ubiquitin-protein transferase activity [GO:0004842]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; regulation of exit from mitosis [GO:0007096]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q9UJX3	reviewed	APC7_HUMAN	Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7)	ANAPC7 APC7	Homo sapiens (Human)	565	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). APC7 is not required for the assembly of the APC/C complex, but has an enzyme-substrate adapter activity mediating the processive ubiquitination of specific substrates (PubMed:34942119). Involved in brain development through the specific ubiquitination and clearance of MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis (PubMed:34942119). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:34942119}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; brain development [GO:0007420]; cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	enzyme-substrate adaptor activity [GO:0140767]; protein phosphatase binding [GO:0019903]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; enzyme-substrate adaptor activity [GO:0140767]; protein phosphatase binding [GO:0019903]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; brain development [GO:0007420]; cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18445686}. Nucleus {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Note=Localizes to spindle during metaphase and to cytoplasmic microtubules during interphase. {ECO:0000269|PubMed:18445686}.
Q9UJX4	reviewed	APC5_HUMAN	Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5)	ANAPC5 APC5	Homo sapiens (Human)	755	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	protein phosphatase binding [GO:0019903]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; protein phosphatase binding [GO:0019903]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}.
Q9UJX5	reviewed	APC4_HUMAN	Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4)	ANAPC4 APC4	Homo sapiens (Human)	808	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein phosphatase binding [GO:0019903]; ubiquitin-protein transferase activity [GO:0004842]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase binding [GO:0019903]; ubiquitin-protein transferase activity [GO:0004842]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18445686}.
Q9UJX6	reviewed	ANC2_HUMAN	Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2)	ANAPC2 APC2 KIAA1406	Homo sapiens (Human)	822	FUNCTION: Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. {ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell differentiation [GO:0030154]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	ubiquitin protein ligase binding [GO:0031625]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ubiquitin protein ligase binding [GO:0031625]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell differentiation [GO:0030154]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	
Q9UJY1	reviewed	HSPB8_HUMAN	Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Protein kinase H11) (Small stress protein-like protein HSP22)	HSPB8 CRYAC E2IG1 HSP22 PP1629	Homo sapiens (Human)	196	FUNCTION: Displays temperature-dependent chaperone activity.		cellular response to unfolded protein [GO:0034620]; positive regulation of aggrephagy [GO:1905337]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; cellular response to unfolded protein [GO:0034620]; positive regulation of aggrephagy [GO:1905337]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326, ECO:0000269|PubMed:28144995}. Nucleus {ECO:0000269|PubMed:19464326}. Note=Translocates to nuclear foci during heat shock.
Q9UJY4	reviewed	GGA2_HUMAN	ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)	GGA2 KIAA1080	Homo sapiens (Human)	613	FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}.		Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; protein localization to cell surface [GO:0034394]	clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802]	phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130]	clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802]; phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; protein localization to cell surface [GO:0034394]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:10749927, ECO:0000269|PubMed:15039775, ECO:0000269|PubMed:28289207}; Peripheral membrane protein {ECO:0000269|PubMed:10749927, ECO:0000269|PubMed:15039775}. Endosome membrane {ECO:0000269|PubMed:15039775}; Peripheral membrane protein {ECO:0000269|PubMed:15039775}. Early endosome membrane {ECO:0000269|PubMed:11950392}; Peripheral membrane protein {ECO:0000305}.
Q9UJY5	reviewed	GGA1_HUMAN	ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)	GGA1	Homo sapiens (Human)	639	FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15886016, PubMed:15615712). {ECO:0000250|UniProtKB:Q8R0H9, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:27901063}.		Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to ciliary membrane [GO:1903441]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; trans-Golgi network [GO:0005802]	phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; trans-Golgi network [GO:0005802]; phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to ciliary membrane [GO:1903441]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15886016}; Peripheral membrane protein. Endosome membrane {ECO:0000269|PubMed:15886016}; Peripheral membrane protein. Early endosome membrane {ECO:0000269|PubMed:15886016}; Peripheral membrane protein {ECO:0000305}.
Q9UJZ1	reviewed	STML2_HUMAN	Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)	STOML2 SLP2 HSPC108	Homo sapiens (Human)	356	FUNCTION: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. {ECO:0000269|PubMed:17121834, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:19597348, ECO:0000269|PubMed:19944461, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}.	MISCELLANEOUS: Paratarg-7/STOML2 is a frequent autoantigenic target in monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia, 3 B-cell neoplasms associated with excessive secretion of a single monoclonal gammaglobulin (also named paraprotein) in the blood. {ECO:0000305|PubMed:19405124}.	CD4-positive, alpha-beta T cell activation [GO:0035710]; intracellular calcium ion homeostasis [GO:0006874]; lipid localization [GO:0010876]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; positive regulation of interleukin-2 production [GO:0032743]; protein complex oligomerization [GO:0051259]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; stress-induced mitochondrial fusion [GO:1990046]; T cell receptor signaling pathway [GO:0050852]	actin cytoskeleton [GO:0015629]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	cardiolipin binding [GO:1901612]; GTPase binding [GO:0051020]; T cell receptor binding [GO:0042608]	actin cytoskeleton [GO:0015629]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; cardiolipin binding [GO:1901612]; GTPase binding [GO:0051020]; T cell receptor binding [GO:0042608]; CD4-positive, alpha-beta T cell activation [GO:0035710]; intracellular calcium ion homeostasis [GO:0006874]; lipid localization [GO:0010876]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; positive regulation of interleukin-2 production [GO:0032743]; protein complex oligomerization [GO:0051259]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; stress-induced mitochondrial fusion [GO:1990046]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}; Peripheral membrane protein {ECO:0000269|PubMed:10713127}. Mitochondrion {ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:19597348, ECO:0000269|PubMed:22623988}. Mitochondrion inner membrane {ECO:0000269|PubMed:17121834, ECO:0000269|PubMed:18339324, ECO:0000269|PubMed:21746876}; Lipid-anchor {ECO:0000269|PubMed:21746876}. Mitochondrion intermembrane space {ECO:0000269|PubMed:17121834}. Membrane raft {ECO:0000269|PubMed:18641330}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:18641330}. Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain (PubMed:21746876). Also associates with the actin cytoskeleton and membrane rafts in activated T-cells (PubMed:18641330, PubMed:10713127). A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells (PubMed:22623988). {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}.
Q9UK05	reviewed	GDF2_HUMAN	Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9)	GDF2 BMP9	Homo sapiens (Human)	429	FUNCTION: Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. {ECO:0000269|PubMed:18309101, ECO:0000269|PubMed:21710321, ECO:0000269|PubMed:22799562, ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:25237187}.		activin receptor signaling pathway [GO:0032924]; angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; intracellular iron ion homeostasis [GO:0006879]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA replication [GO:0008156]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cartilage development [GO:0061036]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; activin receptor signaling pathway [GO:0032924]; angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; intracellular iron ion homeostasis [GO:0006879]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA replication [GO:0008156]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cartilage development [GO:0061036]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18309101, ECO:0000269|PubMed:21710321, ECO:0000269|PubMed:25237187}.
Q9UK17	reviewed	KCND3_HUMAN	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3)	KCND3	Homo sapiens (Human)	655	FUNCTION: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. {ECO:0000269|PubMed:10200233, ECO:0000269|PubMed:9843794}.		membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of monoatomic ion transmembrane transport [GO:0034765]; ventricular cardiac muscle cell membrane repolarization [GO:0099625]	dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076]	A-type (transient outward) potassium channel activity [GO:0005250]; metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076]; A-type (transient outward) potassium channel activity [GO:0005250]; metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of monoatomic ion transmembrane transport [GO:0034765]; ventricular cardiac muscle cell membrane repolarization [GO:0099625]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q62897}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q62897}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q62897}. Note=Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression. {ECO:0000250|UniProtKB:Q62897}.
Q9UK22	reviewed	FBX2_HUMAN	F-box only protein 2	FBXO2 FBX2	Homo sapiens (Human)	296	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity). {ECO:0000250}.		glycoprotein catabolic process [GO:0006516]; negative regulation of cell population proliferation [GO:0008285]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; regulation of protein ubiquitination [GO:0031396]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; extrinsic component of postsynaptic membrane [GO:0098890]; glutamatergic synapse [GO:0098978]; SCF ubiquitin ligase complex [GO:0019005]	amyloid-beta binding [GO:0001540]; carbohydrate binding [GO:0030246]; denatured protein binding [GO:0031249]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; extrinsic component of postsynaptic membrane [GO:0098890]; glutamatergic synapse [GO:0098978]; SCF ubiquitin ligase complex [GO:0019005]; amyloid-beta binding [GO:0001540]; carbohydrate binding [GO:0030246]; denatured protein binding [GO:0031249]; ubiquitin-protein transferase activity [GO:0004842]; glycoprotein catabolic process [GO:0006516]; negative regulation of cell population proliferation [GO:0008285]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; regulation of protein ubiquitination [GO:0031396]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Q9UK23	reviewed	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase)	NAGPA	Homo sapiens (Human)	515	FUNCTION: Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. {ECO:0000269|PubMed:23572527}.		carbohydrate metabolic process [GO:0005975]; lysosome organization [GO:0007040]; protein modification process [GO:0036211]; protein targeting to lysosome [GO:0006622]; secretion of lysosomal enzymes [GO:0033299]	Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity [GO:0003944]	Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity [GO:0003944]; carbohydrate metabolic process [GO:0005975]; lysosome organization [GO:0007040]; protein modification process [GO:0036211]; protein targeting to lysosome [GO:0006622]; secretion of lysosomal enzymes [GO:0033299]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12058031}; Single-pass type I membrane protein {ECO:0000269|PubMed:12058031}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:12058031}. Note=Cis/medial Golgi.
Q9UK32	reviewed	KS6A6_HUMAN	Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4)	RPS6KA6 RSK4	Homo sapiens (Human)	745	FUNCTION: Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}.		central nervous system development [GO:0007417]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation of embryonic development [GO:0045992]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of mesoderm development [GO:2000381]; phosphorylation [GO:0016310]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; ribosomal protein S6 kinase activity [GO:0004711]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; ribosomal protein S6 kinase activity [GO:0004711]; central nervous system development [GO:0007417]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation of embryonic development [GO:0045992]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of mesoderm development [GO:2000381]; phosphorylation [GO:0016310]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15632195}. Nucleus {ECO:0000269|PubMed:15632195}. Note=Predominantly cytosolic.
Q9UK33	reviewed	ZN580_HUMAN	Zinc finger protein 580 (LDL-induced EC protein)	ZNF580	Homo sapiens (Human)	172	FUNCTION: Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation. {ECO:0000269|PubMed:20382120, ECO:0000269|PubMed:21830064}.		cellular response to hydrogen peroxide [GO:0070301]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte chemotaxis [GO:0002690]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cellular response to hydrogen peroxide [GO:0070301]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte chemotaxis [GO:0002690]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20382120, ECO:0000269|PubMed:21599657}. Note=Colocalized with SMAD2 in the nucleus.
Q9UK39	reviewed	NOCT_HUMAN	Nocturnin (EC 3.1.3.108) (Carbon catabolite repression 4-like protein)	NOCT CCR4 CCRN4L NOC	Homo sapiens (Human)	431	FUNCTION: Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). {ECO:0000250|UniProtKB:O35710, ECO:0000269|PubMed:29860338, ECO:0000269|PubMed:31147539}.		circadian regulation of gene expression [GO:0032922]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; mRNA stabilization [GO:0048255]; NADP metabolic process [GO:0006739]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoblast differentiation [GO:0045668]; P-body assembly [GO:0033962]; positive regulation of fat cell differentiation [GO:0045600]; regulation of circadian rhythm [GO:0042752]; regulation of embryonic development [GO:0045995]; response to extracellular stimulus [GO:0009991]; response to lipopolysaccharide [GO:0032496]; transcription by RNA polymerase II [GO:0006366]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]	3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; NADP phosphatase activity [GO:0019178]; NADPH phosphatase activity [GO:0102757]; poly(A)-specific ribonuclease activity [GO:0004535]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; NADP phosphatase activity [GO:0019178]; NADPH phosphatase activity [GO:0102757]; poly(A)-specific ribonuclease activity [GO:0004535]; circadian regulation of gene expression [GO:0032922]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; mRNA stabilization [GO:0048255]; NADP metabolic process [GO:0006739]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoblast differentiation [GO:0045668]; P-body assembly [GO:0033962]; positive regulation of fat cell differentiation [GO:0045600]; regulation of circadian rhythm [GO:0042752]; regulation of embryonic development [GO:0045995]; response to extracellular stimulus [GO:0009991]; response to lipopolysaccharide [GO:0032496]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O35710}. Nucleus {ECO:0000250|UniProtKB:O35710}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O35710}. Mitochondrion {ECO:0000269|PubMed:31147539}.
Q9UK41	reviewed	VPS28_HUMAN	Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28)	VPS28	Homo sapiens (Human)	221	FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. {ECO:0000269|PubMed:11916981}.		macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]	protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11916981}. Late endosome membrane {ECO:0000269|PubMed:11916981}; Peripheral membrane protein {ECO:0000269|PubMed:11916981}.
Q9UK45	reviewed	LSM7_HUMAN	U6 snRNA-associated Sm-like protein LSm7	LSM7	Homo sapiens (Human)	103	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.		mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process [GO:0000956]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal tri-snRNP complex [GO:0097526]; U12-type spliceosomal complex [GO:0005689]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]	U6 snRNA binding [GO:0017070]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal tri-snRNP complex [GO:0097526]; U12-type spliceosomal complex [GO:0005689]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]; U6 snRNA binding [GO:0017070]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process [GO:0000956]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
Q9UK53	reviewed	ING1_HUMAN	Inhibitor of growth protein 1	ING1	Homo sapiens (Human)	422	FUNCTION: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:9440695}.		cell cycle [GO:0007049]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; protein import into nucleus [GO:0006606]; regulation of programmed cell death [GO:0043067]	nucleus [GO:0005634]; Sin3 complex [GO:0016580]	metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]	nucleus [GO:0005634]; Sin3 complex [GO:0016580]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; cell cycle [GO:0007049]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; protein import into nucleus [GO:0006606]; regulation of programmed cell death [GO:0043067]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UK55	reviewed	ZPI_HUMAN	Protein Z-dependent protease inhibitor (PZ-dependent protease inhibitor) (PZI) (Serpin A10)	SERPINA10 ZPI UNQ707/PRO1358	Homo sapiens (Human)	444	FUNCTION: Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors. {ECO:0000269|PubMed:11049983}.	MISCELLANEOUS: Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.	blood coagulation [GO:0007596]; liver regeneration [GO:0097421]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]; blood coagulation [GO:0007596]; liver regeneration [GO:0097421]	SUBCELLULAR LOCATION: Secreted.
Q9UK58	reviewed	CCNL1_HUMAN	Cyclin-L1 (Cyclin-L)	CCNL1 BM-001 UNQ530/PRO1073	Homo sapiens (Human)	526	FUNCTION: Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036, ECO:0000269|PubMed:18216018}.	MISCELLANEOUS: CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional metastases and an unfavorable clinical outcome of HNSCC.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of centrosome cycle [GO:0046605]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of centrosome cycle [GO:0046605]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:18216018}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18216018}. Note=Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. {ECO:0000250}.
Q9UK59	reviewed	DBR1_HUMAN	Lariat debranching enzyme (EC 3.1.4.-)	DBR1	Homo sapiens (Human)	544	FUNCTION: Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:10982890, PubMed:2435736, PubMed:16232320). Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem (PubMed:16232320, PubMed:29474921). {ECO:0000269|PubMed:10982890, ECO:0000269|PubMed:16232320, ECO:0000269|PubMed:2435736, ECO:0000269|PubMed:29474921}.		mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA lariat debranching enzyme activity [GO:0008419]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA lariat debranching enzyme activity [GO:0008419]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UK61	reviewed	TASOR_HUMAN	Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein)	TASOR C3orf63 FAM208A KIAA1105	Homo sapiens (Human)	1670	FUNCTION: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}.	MISCELLANEOUS: [Isoform 1]: Gene prediction based on partial mRNA data. {ECO:0000305}.	anterior/posterior axis specification, embryo [GO:0008595]; mesodermal to mesenchymal transition involved in gastrulation [GO:0060809]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; protein localization to heterochromatin [GO:0097355]	heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; RNA binding [GO:0003723]	heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; RNA binding [GO:0003723]; anterior/posterior axis specification, embryo [GO:0008595]; mesodermal to mesenchymal transition involved in gastrulation [GO:0060809]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; protein localization to heterochromatin [GO:0097355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500}. Chromosome {ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500}. Note=Localizes to chromatin. {ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500}.
Q9UK73	reviewed	FEM1B_HUMAN	Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha)	FEM1B F1AA KIAA0396	Homo sapiens (Human)	627	FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33398170, PubMed:33398168). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:33398170, PubMed:33398168). The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation (PubMed:33398170, PubMed:33398168). Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS) (By similarity). Mechanistically, recognizes and binds reduced FNIP1 through two interface zinc ions, which act as a molecular glue that recruit reduced FNIP1 to FEM1B (By similarity). Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity (PubMed:24076122). Promotes ubiquitination and degradation of ANKRD37 (By similarity). Promotes ubiquitination and degradation of SLBP (PubMed:28118078). Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (PubMed:10542291). Also involved in glucose homeostasis in pancreatic islet (By similarity). May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (PubMed:19330022). {ECO:0000250|UniProtKB:Q9Z2G0, ECO:0000269|PubMed:10542291, ECO:0000269|PubMed:19330022, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:28118078, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:33398168, ECO:0000269|PubMed:33398170}.		apoptotic process [GO:0006915]; branching involved in prostate gland morphogenesis [GO:0060442]; epithelial cell maturation involved in prostate gland development [GO:0060743]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of ubiquitin-protein transferase activity [GO:0051438]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	death receptor binding [GO:0005123]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; death receptor binding [GO:0005123]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; apoptotic process [GO:0006915]; branching involved in prostate gland morphogenesis [GO:0060442]; epithelial cell maturation involved in prostate gland development [GO:0060743]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of ubiquitin-protein transferase activity [GO:0051438]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19330022, ECO:0000269|PubMed:24076122}. Nucleus {ECO:0000269|PubMed:19330022}. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment (PubMed:19330022). Associated with chromatin (PubMed:19330022). {ECO:0000269|PubMed:19330022}.
Q9UK76	reviewed	JUPI1_HUMAN	Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed]	JPT1 ARM2 HN1	Homo sapiens (Human)	154	FUNCTION: Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}.			cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]		cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21323578}. Cytoplasm {ECO:0000269|PubMed:25169422}.
Q9UK80	reviewed	UBP21_HUMAN	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21)	USP21 USP23 PP1490	Homo sapiens (Human)	565	FUNCTION: Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (By similarity). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (By similarity). Regulates gene expression via histone H2A deubiquitination (By similarity). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). {ECO:0000250|UniProtKB:Q9QZL6, ECO:0000269|PubMed:10799498, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:32011234}.		proteolysis [GO:0006508]; transcription initiation-coupled chromatin remodeling [GO:0045815]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; deNEDDylase activity [GO:0019784]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; deNEDDylase activity [GO:0019784]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; proteolysis [GO:0006508]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21888622}. Nucleus {ECO:0000269|PubMed:21888622}.
Q9UK96	reviewed	FBX10_HUMAN	F-box only protein 10	FBXO10 FBX10 PRMT11	Homo sapiens (Human)	956	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Targets also the receptor for advanced glycation end products RAGE for ubiquitination and subsequent lysosomal degradation (PubMed:28515150). Directly controls HGAL/GCSAM ubiquitination and degradation and thereby decreases BCR signaling (PubMed:31570756). {ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:28515150, ECO:0000269|PubMed:31570756}.		apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]	ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:31570756}.
Q9UK97	reviewed	FBX9_HUMAN	F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57)	FBXO9 FBX9 VCIA1	Homo sapiens (Human)	447	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability (PubMed:34480022, PubMed:23263282). Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1 (PubMed:23263282). Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway (PubMed:34480022). Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BK06, ECO:0000269|PubMed:23263282, ECO:0000269|PubMed:34480022}.	MISCELLANEOUS: Overexpressed in multiple myeloma leading to constitutive activation of the PI(3)K/mTORC2/Akt pathway to promote survival. {ECO:0000305|PubMed:23263282}.	fat cell differentiation [GO:0045444]; innate immune response [GO:0045087]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of TOR signaling [GO:0032006]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]	ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]; fat cell differentiation [GO:0045444]; innate immune response [GO:0045087]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of TOR signaling [GO:0032006]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23263282}.
Q9UK99	reviewed	FBX3_HUMAN	F-box only protein 3	FBXO3 FBX3	Homo sapiens (Human)	471	FUNCTION: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:18809579, PubMed:26037928). Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome (PubMed:18809579). In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented (PubMed:18809579). PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (PubMed:18809579). The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS) (PubMed:26037928). The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q9DC63, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:26037928}.		protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; response to lipopolysaccharide [GO:0032496]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]	ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; response to lipopolysaccharide [GO:0032496]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18809579}. Note=Colocalizes with PML at the peripheries of nuclear bodies. {ECO:0000269|PubMed:18809579}.
Q9UKA1	reviewed	FBXL5_HUMAN	F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) (F-box protein FBL4/FBL5) (p45SKP2-like protein)	FBXL5 FBL4 FBL5 FLR1	Homo sapiens (Human)	691	FUNCTION: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2 (PubMed:19762596, PubMed:19762597). The C-terminal domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes binding to IRP2 to effect its oxygen-dependent degradation (PubMed:32126207). Under iron deficiency conditions, the N-terminal hemerythrin-like (Hr) region, which contains a diiron metal center, cannot bind iron and undergoes conformational changes that destabilize the FBXL5 protein and cause its ubiquitination and degradation (PubMed:19762596, PubMed:19762597). When intracellular iron levels start rising, the Hr region is stabilized (PubMed:19762596, PubMed:19762597). Additional increases in iron levels facilitate the assembly and incorporation of a redox active [2Fe-2S] cluster in the C-terminal domain (PubMed:32126207). Only when oxygen level is high enough to maintain the cluster in its oxidized state can FBXL5 recruit IRP2 as a substrate for polyubiquination and degradation (PubMed:32126207). Promotes ubiquitination and subsequent degradation of the dynactin complex component DCTN1 (PubMed:17532294). Within the nucleus, promotes the ubiquitination of SNAI1; preventing its interaction with DNA and promoting its degradation (PubMed:24157836). Negatively regulates DNA damage response by mediating the ubiquitin-proteasome degradation of the DNA repair protein NABP2 (PubMed:25249620). {ECO:0000269|PubMed:17532294, ECO:0000269|PubMed:19762596, ECO:0000269|PubMed:19762597, ECO:0000269|PubMed:32126207}.	MISCELLANEOUS: Binds a diiron center, that can be bridged by a hydroxo group. The hydroxo bridge is not present when FBXL5 is in the reduced form and seems to play a critical role in regulating iron binding. {ECO:0000269|PubMed:22492618}.	intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]	iron ion binding [GO:0005506]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; iron ion binding [GO:0005506]; ubiquitin-protein transferase activity [GO:0004842]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17532294}. Nucleus {ECO:0000269|PubMed:24157836}.
Q9UKA2	reviewed	FBXL4_HUMAN	F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5)	FBXL4 FBL4 FBL5	Homo sapiens (Human)	621			autophagy of mitochondrion [GO:0000422]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; nuclear speck [GO:0016607]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]		cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; nuclear speck [GO:0016607]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; autophagy of mitochondrion [GO:0000422]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion.
Q9UKA4	reviewed	AKA11_HUMAN	A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11)	AKAP11 AKAP220 KIAA0629	Homo sapiens (Human)	1901	FUNCTION: Binds to type II regulatory subunits of protein kinase A and anchors/targets them.		cortical actin cytoskeleton organization [GO:0030866]; intracellular signal transduction [GO:0035556]; protein localization [GO:0008104]; protein localization to endosome [GO:0036010]; renal water homeostasis [GO:0003091]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein phosphatase 1 binding [GO:0008157]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein phosphatase 1 binding [GO:0008157]; cortical actin cytoskeleton organization [GO:0030866]; intracellular signal transduction [GO:0035556]; protein localization [GO:0008104]; protein localization to endosome [GO:0036010]; renal water homeostasis [GO:0003091]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.
Q9UKA8	reviewed	RCAN3_HUMAN	Calcipressin-3 (Down syndrome candidate region 1-like protein 2) (Myocyte-enriched calcineurin-interacting protein 3) (MCIP3) (Regulator of calcineurin 3)	RCAN3 DSCR1L2	Homo sapiens (Human)	241	FUNCTION: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity). {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; calcium-mediated signaling [GO:0019722]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; phosphatase binding [GO:0019902]; RNA binding [GO:0003723]; troponin I binding [GO:0031013]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; phosphatase binding [GO:0019902]; RNA binding [GO:0003723]; troponin I binding [GO:0031013]; anatomical structure morphogenesis [GO:0009653]; calcium-mediated signaling [GO:0019722]	
Q9UKA9	reviewed	PTBP2_HUMAN	Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (Neurally-enriched homolog of PTB) (PTB-like protein)	PTBP2 NPTB PTB PTBLP	Homo sapiens (Human)	531	FUNCTION: RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. {ECO:0000250|UniProtKB:Q91Z31, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:12667457}.; FUNCTION: [Isoform 5]: Reduced affinity for RNA. {ECO:0000269|PubMed:12213192}.		mRNA splice site recognition [GO:0006376]; negative regulation of RNA splicing [GO:0033119]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of RNA splicing [GO:0043484]	nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA splice site recognition [GO:0006376]; negative regulation of RNA splicing [GO:0033119]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91Z31}.
Q9UKB1	reviewed	FBW1B_HUMAN	F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)	FBXW11 BTRCP2 FBW1B FBXW1B KIAA0696	Homo sapiens (Human)	542	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10437795, PubMed:11158290, PubMed:10648623, PubMed:20347421, PubMed:19966869, PubMed:22017875, PubMed:22017876, PubMed:36608670). Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S (PubMed:10437795, PubMed:10648623, PubMed:20347421, PubMed:19966869, PubMed:22017875, PubMed:22017876, PubMed:36608670). SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation (PubMed:10321728). SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription (PubMed:10321728, PubMed:10644755, PubMed:10437795, PubMed:20347421). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (PubMed:11158290). SCF(FBXW11) mediates the ubiquitination of IFNAR1 (PubMed:14532120, PubMed:15337770). SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1 (PubMed:18575781). Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint (PubMed:14603323). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2 (PubMed:15917222). SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262). SCF(FBXW11) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (PubMed:22017875, PubMed:22017876, PubMed:36608670). {ECO:0000269|PubMed:10321728, ECO:0000269|PubMed:10437795, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10648623, ECO:0000269|PubMed:11158290, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:15337770, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18575781, ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:20347421, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:29420262, ECO:0000269|PubMed:36608670}.; FUNCTION: (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. {ECO:0000269|PubMed:19730691}.		brain morphogenesis [GO:0048854]; establishment of mitotic spindle orientation [GO:0000132]; germ cell development [GO:0007281]; microtubule organizing center organization [GO:0031023]; negative regulation of DNA-templated transcription [GO:0045892]; nuclear migration [GO:0007097]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteolysis [GO:0045862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; retrograde axonal transport [GO:0008090]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; vesicle transport along microtubule [GO:0047496]; Wnt signaling pathway [GO:0016055]	axon cytoplasm [GO:1904115]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]	dynein complex binding [GO:0070840]; microtubule plus-end binding [GO:0051010]; protein dimerization activity [GO:0046983]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	axon cytoplasm [GO:1904115]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; dynein complex binding [GO:0070840]; microtubule plus-end binding [GO:0051010]; protein dimerization activity [GO:0046983]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; brain morphogenesis [GO:0048854]; establishment of mitotic spindle orientation [GO:0000132]; germ cell development [GO:0007281]; microtubule organizing center organization [GO:0031023]; negative regulation of DNA-templated transcription [GO:0045892]; nuclear migration [GO:0007097]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteolysis [GO:0045862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; retrograde axonal transport [GO:0008090]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; vesicle transport along microtubule [GO:0047496]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5SRY7}. Nucleus {ECO:0000250|UniProtKB:Q5SRY7}.
Q9UKB5	reviewed	AJAP1_HUMAN	Adherens junction-associated protein 1 (Membrane protein shrew-1)	AJAP1 MOT8 SHREW1	Homo sapiens (Human)	411	FUNCTION: Plays a role in cell adhesion and cell migration. {ECO:0000269|PubMed:16410724, ECO:0000269|PubMed:17267690}.		cell adhesion [GO:0007155]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of wound healing [GO:0061045]; regulation of polarized epithelial cell differentiation [GO:0030860]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cell-cell contact zone [GO:0044291]; cytoplasmic side of plasma membrane [GO:0009898]; plasma membrane [GO:0005886]	beta-catenin binding [GO:0008013]; protein-containing complex binding [GO:0044877]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cell-cell contact zone [GO:0044291]; cytoplasmic side of plasma membrane [GO:0009898]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; protein-containing complex binding [GO:0044877]; cell adhesion [GO:0007155]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of wound healing [GO:0061045]; regulation of polarized epithelial cell differentiation [GO:0030860]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:16707570}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:16707570}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000269|PubMed:14595118}. Note=Mainly basolateral (PubMed:16707570). Localization is mediated by AP1M2 (PubMed:16707570). {ECO:0000269|PubMed:16707570}.
Q9UKC9	reviewed	FBXL2_HUMAN	F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3)	FBXL2 FBL2 FBL3	Homo sapiens (Human)	423	FUNCTION: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:22020328, PubMed:22323446). Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin (PubMed:22020328, PubMed:22323446). This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin (PubMed:22020328, PubMed:22323446). Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity). The SCF(FBXL2) complex acts as a regulator of inflammation by mediating ubiquitination and degradation of TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6) (By similarity). The SCF(FBXL2) complex acts as a negative regulator of the NLRP3 inflammasome by mediating ubiquitination and degradation of NLRP3 (PubMed:26037928). {ECO:0000250|UniProtKB:Q8BH16, ECO:0000269|PubMed:22020328, ECO:0000269|PubMed:22323446, ECO:0000269|PubMed:23604317, ECO:0000269|PubMed:26037928}.	MISCELLANEOUS: Deletion of the F-box domain creates a dominant-negative protein that inhibits replication of hepatitis C virus RNA when overexpressed in a hepatoma cell line; this inhibition could be overcome by NS5A coexpression. {ECO:0000269|PubMed:15893726}.	modulation by host of viral RNA genome replication [GO:0044830]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]; regulation of inflammatory response [GO:0050727]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytoplasm [GO:0005737]; membrane [GO:0016020]; SCF ubiquitin ligase complex [GO:0019005]	calmodulin binding [GO:0005516]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein phosphatase binding [GO:0019903]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	cytoplasm [GO:0005737]; membrane [GO:0016020]; SCF ubiquitin ligase complex [GO:0019005]; calmodulin binding [GO:0005516]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein phosphatase binding [GO:0019903]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]; regulation of inflammatory response [GO:0050727]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15893726}; Lipid-anchor {ECO:0000269|PubMed:15893726}.
Q9UKD1	reviewed	GMEB2_HUMAN	Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79)	GMEB2 KIAA1269	Homo sapiens (Human)	530	FUNCTION: Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.		regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=May be also cytoplasmic.
Q9UKE5	reviewed	TNIK_HUMAN	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)	TNIK KIAA0551	Homo sapiens (Human)	1360	FUNCTION: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388}.		actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of dendrite morphogenesis [GO:0048814]; regulation of MAPK cascade [GO:0043408]; response to organonitrogen compound [GO:0010243]; Wnt signaling pathway [GO:0016055]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density, intracellular component [GO:0099092]; presynapse [GO:0098793]; recycling endosome [GO:0055037]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density, intracellular component [GO:0099092]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of dendrite morphogenesis [GO:0048814]; regulation of MAPK cascade [GO:0043408]; response to organonitrogen compound [GO:0010243]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Q9UKF2	reviewed	ADA30_HUMAN	Disintegrin and metalloproteinase domain-containing protein 30 (ADAM 30) (EC 3.4.24.-)	ADAM30 UNQ2509/PRO5997	Homo sapiens (Human)	790	FUNCTION: Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034). {ECO:0000269|PubMed:27333034}.		male gonad development [GO:0008584]; proteolysis [GO:0006508]	external side of plasma membrane [GO:0009897]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	external side of plasma membrane [GO:0009897]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; male gonad development [GO:0008584]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:27333034}; Single-pass type I membrane protein {ECO:0000255}.
Q9UKF5	reviewed	ADA29_HUMAN	Disintegrin and metalloproteinase domain-containing protein 29 (ADAM 29) (Cancer/testis antigen 73) (CT73)	ADAM29	Homo sapiens (Human)	820	FUNCTION: May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.		male gonad development [GO:0008584]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; male gonad development [GO:0008584]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9UKF6	reviewed	CPSF3_HUMAN	Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73)	CPSF3 CPSF73	Homo sapiens (Human)	684	FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease (PubMed:30507380). Also involved in the histone 3'-end pre-mRNA processing (PubMed:30507380). U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for entering/progressing through S-phase of the cell cycle (PubMed:30507380). Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). {ECO:0000250|UniProtKB:Q9QXK7, ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:15037765, ECO:0000269|PubMed:17128255, ECO:0000269|PubMed:18688255, ECO:0000269|PubMed:30507380}.		co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA 3'-end processing [GO:0031124]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; mRNA polyadenylation [GO:0006378]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]	5'-3' RNA exonuclease activity [GO:0004534]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; 5'-3' RNA exonuclease activity [GO:0004534]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA 3'-end processing [GO:0031124]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; mRNA polyadenylation [GO:0006378]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15037765}.
Q9UKF7	reviewed	PITC1_HUMAN	Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta)	PITPNC1	Homo sapiens (Human)	332	FUNCTION: [Isoform 1]: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (PubMed:22822086). {ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:22822086}.; FUNCTION: [Isoform 2]: Catalyzes the transfer of phosphatidylinositol between membranes. {ECO:0000269|PubMed:22822086}.		phospholipid transport [GO:0015914]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	phosphatidic acid binding [GO:0070300]; phosphatidic acid transfer activity [GO:1990050]; phosphatidylglycerol binding [GO:1901611]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; phosphatidic acid binding [GO:0070300]; phosphatidic acid transfer activity [GO:1990050]; phosphatidylglycerol binding [GO:1901611]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; phospholipid transport [GO:0015914]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10531358}.
Q9UKG1	reviewed	DP13A_HUMAN	DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)	APPL1 APPL DIP13A KIAA1428	Homo sapiens (Human)	709	FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:26073777, PubMed:19661063, PubMed:10490823). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:26073777, PubMed:19661063, PubMed:24879834). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}.		adiponectin-activated signaling pathway [GO:0033211]; cell cycle [GO:0007049]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; insulin receptor signaling pathway [GO:0008286]; maintenance of synapse structure [GO:0099558]; negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905450]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of glucose import [GO:0046326]; positive regulation of macropinocytosis [GO:1905303]; positive regulation of melanin biosynthetic process [GO:0048023]; protein import into nucleus [GO:0006606]; regulation of fibroblast migration [GO:0010762]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of glucose import [GO:0046324]; regulation of innate immune response [GO:0045088]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; signal transduction [GO:0007165]; signaling [GO:0023052]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; intracellular vesicle [GO:0097708]; macropinosome [GO:0044354]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; ruffle [GO:0001726]; vesicle membrane [GO:0012506]	beta-tubulin binding [GO:0048487]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein kinase B binding [GO:0043422]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; intracellular vesicle [GO:0097708]; macropinosome [GO:0044354]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; ruffle [GO:0001726]; vesicle membrane [GO:0012506]; beta-tubulin binding [GO:0048487]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein kinase B binding [GO:0043422]; protein-containing complex binding [GO:0044877]; adiponectin-activated signaling pathway [GO:0033211]; cell cycle [GO:0007049]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; insulin receptor signaling pathway [GO:0008286]; maintenance of synapse structure [GO:0099558]; negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905450]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of glucose import [GO:0046326]; positive regulation of macropinocytosis [GO:1905303]; positive regulation of melanin biosynthetic process [GO:0048023]; protein import into nucleus [GO:0006606]; regulation of fibroblast migration [GO:0010762]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of glucose import [GO:0046324]; regulation of innate immune response [GO:0045088]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; signal transduction [GO:0007165]; signaling [GO:0023052]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:20133602, ECO:0000269|PubMed:21645192}; Peripheral membrane protein {ECO:0000269|PubMed:15016378}. Nucleus {ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:26583432}. Cytoplasm {ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063}. Endosome {ECO:0000269|PubMed:26583432}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8K3H0}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q8K3H0}. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. {ECO:0000269|PubMed:15016378}.
Q9UKG4	reviewed	S13A4_HUMAN	Solute carrier family 13 member 4 (Na(+)/sulfate cotransporter SUT-1) (NaS2)	SLC13A4 SUT1	Homo sapiens (Human)	626	FUNCTION: Sodium:sulfate symporter that mediates sulfate reabsorption in the high endothelial venules (HEV). {ECO:0000269|PubMed:10535998, ECO:0000269|PubMed:15607730}.		sulfate transport [GO:0008272]	plasma membrane [GO:0005886]	sodium:sulfate symporter activity [GO:0015382]	plasma membrane [GO:0005886]; sodium:sulfate symporter activity [GO:0015382]; sulfate transport [GO:0008272]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein {ECO:0000255}.
Q9UKG9	reviewed	OCTC_HUMAN	Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137)	CROT COT	Homo sapiens (Human)	612	FUNCTION: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester. {ECO:0000269|PubMed:10486279}.		carnitine metabolic process [GO:0009437]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; generation of precursor metabolites and energy [GO:0006091]; medium-chain fatty acid metabolic process [GO:0051791]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	carnitine O-octanoyltransferase activity [GO:0008458]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; carnitine O-octanoyltransferase activity [GO:0008458]; carnitine metabolic process [GO:0009437]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; generation of precursor metabolites and energy [GO:0006091]; medium-chain fatty acid metabolic process [GO:0051791]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000305}.
Q9UKI2	reviewed	BORG2_HUMAN	Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein)	CDC42EP3 BORG2 CEP3	Homo sapiens (Human)	254	FUNCTION: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}.		positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]	cytoskeletal regulatory protein binding [GO:0005519]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; cytoskeletal regulatory protein binding [GO:0005519]; small GTPase binding [GO:0031267]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:11035016}; Peripheral membrane protein {ECO:0000269|PubMed:11035016}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11035016}.
Q9UKI8	reviewed	TLK1_HUMAN	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1)	TLK1 KIAA0137	Homo sapiens (Human)	766	FUNCTION: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}.		chromatin organization [GO:0006325]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; intracellular protein transport [GO:0006886]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of chromatin organization [GO:1902275]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; chromatin organization [GO:0006325]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; intracellular protein transport [GO:0006886]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of chromatin organization [GO:1902275]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:9427565}.
Q9UKI9	reviewed	PO2F3_HUMAN	POU domain, class 2, transcription factor 3 (Octamer-binding protein 11) (Oct-11) (Octamer-binding transcription factor 11) (OTF-11) (Transcription factor PLA-1) (Transcription factor Skn-1)	POU2F3 OTF11 PLA1	Homo sapiens (Human)	436	FUNCTION: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:11329378). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971). {ECO:0000269|PubMed:11329378, ECO:0000269|PubMed:35576971}.		epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; negative regulation by host of viral transcription [GO:0043922]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; wound healing [GO:0042060]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; negative regulation by host of viral transcription [GO:0043922]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P31362}.
Q9UKJ1	reviewed	PILRA_HUMAN	Paired immunoglobulin-like type 2 receptor alpha (Cell surface receptor FDF03) (Inhibitory receptor PILR-alpha)	PILRA	Homo sapiens (Human)	303	FUNCTION: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. {ECO:0000269|PubMed:10903717, ECO:0000269|PubMed:21241660}.; FUNCTION: (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1. {ECO:0000269|PubMed:18358807}.		signal transduction [GO:0007165]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	MHC class I protein binding [GO:0042288]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; MHC class I protein binding [GO:0042288]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000305}.
Q9UKJ5	reviewed	CHIC2_HUMAN	Cysteine-rich hydrophobic domain-containing protein 2 (BrX-like translocated in leukemia)	CHIC2 BTL	Homo sapiens (Human)	165				Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]		Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11257495}. Cytoplasmic vesicle {ECO:0000269|PubMed:11257495}. Note=Also present at a Golgi-like vesicular compartment and at scattered vesicles.
Q9UKJ8	reviewed	ADA21_HUMAN	Disintegrin and metalloproteinase domain-containing protein 21 (ADAM 21) (EC 3.4.24.-)	ADAM21	Homo sapiens (Human)	722	FUNCTION: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients.	MISCELLANEOUS: May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human.	male gonad development [GO:0008584]; proteolysis [GO:0006508]; single fertilization [GO:0007338]	axon [GO:0030424]; external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	axon [GO:0030424]; external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; male gonad development [GO:0008584]; proteolysis [GO:0006508]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9UKK3	reviewed	PARP4_HUMAN	Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP)	PARP4 ADPRTL1 KIAA0177 PARPL	Homo sapiens (Human)	1724	FUNCTION: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}.		DNA damage response [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein modification process [GO:0036211]; regulation of telomerase activity [GO:0051972]; response to xenobiotic stimulus [GO:0009410]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spindle microtubule [GO:0005876]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spindle microtubule [GO:0005876]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein modification process [GO:0036211]; regulation of telomerase activity [GO:0051972]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10477748}. Nucleus {ECO:0000269|PubMed:10477748}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10477748}. Note=Also found in the nucleus, associated with mitotic spindles. {ECO:0000269|PubMed:10477748}.
Q9UKK6	reviewed	NXT1_HUMAN	NTF2-related export protein 1 (Protein p15)	NXT1	Homo sapiens (Human)	140	FUNCTION: Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602). {ECO:0000269|PubMed:10567585, ECO:0000269|PubMed:10848583, ECO:0000269|PubMed:11259602, ECO:0000269|PubMed:19165146}.		mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein export from nucleus [GO:0006611]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; nuclear RNA export factor complex [GO:0042272]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; nuclear RNA export factor complex [GO:0042272]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small GTPase binding [GO:0031267]; mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein export from nucleus [GO:0006611]	SUBCELLULAR LOCATION: Nucleus. Nucleus speckle {ECO:0000305}. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Q9UKK9	reviewed	NUDT5_HUMAN	ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H)	NUDT5 NUDIX5 HSPC115	Homo sapiens (Human)	219	FUNCTION: Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q9JKX6, ECO:0000269|PubMed:10567213, ECO:0000269|PubMed:10722730, ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:19699693, ECO:0000269|PubMed:21389046, ECO:0000269|PubMed:27257257}.		ATP generation from poly-ADP-D-ribose [GO:1990966]; chromatin remodeling [GO:0006338]; D-ribose catabolic process [GO:0019303]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside phosphate metabolic process [GO:0006753]; nucleotide metabolic process [GO:0009117]; ribonucleoside diphosphate catabolic process [GO:0009191]; ribose phosphate metabolic process [GO:0019693]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; snoRNA binding [GO:0030515]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; 8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; snoRNA binding [GO:0030515]; ATP generation from poly-ADP-D-ribose [GO:1990966]; chromatin remodeling [GO:0006338]; D-ribose catabolic process [GO:0019303]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside phosphate metabolic process [GO:0006753]; nucleotide metabolic process [GO:0009117]; ribonucleoside diphosphate catabolic process [GO:0009191]; ribose phosphate metabolic process [GO:0019693]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:27257257}.
Q9UKL0	reviewed	RCOR1_HUMAN	REST corepressor 1 (Protein CoREST)	RCOR1 KIAA0071 RCOR	Homo sapiens (Human)	485	FUNCTION: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}.		chromatin organization [GO:0006325]; erythrocyte differentiation [GO:0030218]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA repair complex [GO:1990391]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714]	DNA repair complex [GO:1990391]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714]; chromatin organization [GO:0006325]; erythrocyte differentiation [GO:0030218]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:15897453}. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.
Q9UKL3	reviewed	C8AP2_HUMAN	CASP8-associated protein 2 (FLICE-associated huge protein)	CASP8AP2 FLASH KIAA1315 RIP25	Homo sapiens (Human)	1982	FUNCTION: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; cell cycle [GO:0007049]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; Fas signaling pathway [GO:0036337]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; death receptor binding [GO:0005123]; peptidase activator activity involved in apoptotic process [GO:0016505]; SUMO polymer binding [GO:0032184]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; death receptor binding [GO:0005123]; peptidase activator activity involved in apoptotic process [GO:0016505]; SUMO polymer binding [GO:0032184]; transcription corepressor activity [GO:0003714]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; cell cycle [GO:0007049]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; Fas signaling pathway [GO:0036337]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation.
Q9UKL6	reviewed	PPCT_HUMAN	Phosphatidylcholine transfer protein (PC-TP) (START domain-containing protein 2) (StARD2) (StAR-related lipid transfer protein 2)	PCTP STARD2	Homo sapiens (Human)	214	FUNCTION: Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule. {ECO:0000269|PubMed:12055623}.		lipid transport [GO:0006869]; negative regulation of cold-induced thermogenesis [GO:0120163]; phospholipid transport [GO:0015914]	cytosol [GO:0005829]	phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]	cytosol [GO:0005829]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; lipid transport [GO:0006869]; negative regulation of cold-induced thermogenesis [GO:0120163]; phospholipid transport [GO:0015914]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P53808}.
Q9UKM7	reviewed	MA1B1_HUMAN	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1)	MAN1B1 UNQ747/PRO1477	Homo sapiens (Human)	699	FUNCTION: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). {ECO:0000269|PubMed:12090241, ECO:0000269|PubMed:18003979}.		endoplasmic reticulum mannose trimming [GO:1904380]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; oligosaccharide metabolic process [GO:0009311]; protein alpha-1,2-demannosylation [GO:0036508]; trimming of terminal mannose on B branch [GO:0036509]; ubiquitin-dependent ERAD pathway [GO:0030433]; viral protein processing [GO:0019082]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]; endoplasmic reticulum mannose trimming [GO:1904380]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; oligosaccharide metabolic process [GO:0009311]; protein alpha-1,2-demannosylation [GO:0036508]; trimming of terminal mannose on B branch [GO:0036509]; ubiquitin-dependent ERAD pathway [GO:0030433]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10409699}; Single-pass type II membrane protein {ECO:0000269|PubMed:10409699}.
Q9UKM9	reviewed	RALY_HUMAN	RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog)	RALY HNRPCL2 P542	Homo sapiens (Human)	306	FUNCTION: RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). {ECO:0000250|UniProtKB:Q64012, ECO:0000269|PubMed:9376072}.	MISCELLANEOUS: Autoantigen found in infectious mononucleosis caused by Epstein-Barr virus. An epitope recognized by B-cells, which cross-react with the BKRF1 protein (EBNA-1 nuclear protein) of Epstein-Barr virus has been identified. {ECO:0000269|PubMed:9376072}.	cholesterol homeostasis [GO:0042632]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of transcription by RNA polymerase II [GO:0000122]	catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]	RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712]	catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712]; cholesterol homeostasis [GO:0042632]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q64012}.
Q9UKN1	reviewed	MUC12_HUMAN	Mucin-12 (MUC-12) (Mucin-11) (MUC-11)	MUC12 MUC11	Homo sapiens (Human)	5478	FUNCTION: Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}.	MISCELLANEOUS: Infection by L.monocytogenes induces increases in mucin secretion and MUC4 and MUC12 transcription. This may constitute a host cell defense response that inhibits the entry of listeria monocytogenes in the cell.	regulation of cell growth [GO:0001558]	Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]		Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; regulation of cell growth [GO:0001558]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9UKN5	reviewed	PRDM4_HUMAN	PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4)	PRDM4 PFM1	Homo sapiens (Human)	801	FUNCTION: May function as a transcription factor involved in cell differentiation.		cell fate commitment [GO:0045165]; methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	cytoplasm [GO:0005737]; histone methyltransferase complex [GO:0035097]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; histone methyltransferase complex [GO:0035097]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell fate commitment [GO:0045165]; methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UKN7	reviewed	MYO15_HUMAN	Unconventional myosin-XV (Unconventional myosin-15)	MYO15A MYO15	Homo sapiens (Human)	3530	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; response to light stimulus [GO:0009416]; sensory perception of sound [GO:0007605]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; actin-based cell projection [GO:0098858]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; myosin complex [GO:0016459]; stereocilium [GO:0032420]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]	actin cytoskeleton [GO:0015629]; actin-based cell projection [GO:0098858]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; myosin complex [GO:0016459]; stereocilium [GO:0032420]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; actin filament organization [GO:0007015]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; response to light stimulus [GO:0009416]; sensory perception of sound [GO:0007605]; vesicle transport along actin filament [GO:0030050]	SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localizes to stereocilium tips in cochlear and vestibular hair cells. {ECO:0000250}.
Q9UKN8	reviewed	TF3C4_HUMAN	General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta)	GTF3C4	Homo sapiens (Human)	822	FUNCTION: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.		5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription by RNA polymerase III [GO:0042797]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]	DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; histone acetyltransferase activity [GO:0004402]; RNA polymerase III general transcription initiation factor activity [GO:0000995]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; histone acetyltransferase activity [GO:0004402]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; 5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription by RNA polymerase III [GO:0042797]	SUBCELLULAR LOCATION: Nucleus.
Q9UKP3	reviewed	ITBP2_HUMAN	Integrin beta-1-binding protein 2 (Melusin)	ITGB1BP2 MSTP015	Homo sapiens (Human)	347	FUNCTION: May play a role during maturation and/or organization of muscles cells.		muscle organ development [GO:0007517]; signal transduction [GO:0007165]	Z disc [GO:0030018]	calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; SH3 domain binding [GO:0017124]; zinc ion binding [GO:0008270]	Z disc [GO:0030018]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; SH3 domain binding [GO:0017124]; zinc ion binding [GO:0008270]; muscle organ development [GO:0007517]; signal transduction [GO:0007165]	
Q9UKP4	reviewed	ATS7_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase)	ADAMTS7	Homo sapiens (Human)	1686	FUNCTION: Metalloprotease that may play a role in the degradation of COMP. {ECO:0000269|PubMed:16585064}.		cellular response to BMP stimulus [GO:0071773]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; negative regulation of chondrocyte differentiation [GO:0032331]; ossification involved in bone maturation [GO:0043931]; proteoglycan metabolic process [GO:0006029]; proteolysis involved in protein catabolic process [GO:0051603]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; cellular response to BMP stimulus [GO:0071773]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; negative regulation of chondrocyte differentiation [GO:0032331]; ossification involved in bone maturation [GO:0043931]; proteoglycan metabolic process [GO:0006029]; proteolysis involved in protein catabolic process [GO:0051603]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Also found associated with the external cell surface. {ECO:0000250}.
Q9UKP5	reviewed	ATS6_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAM-TS 6) (ADAM-TS6) (ADAMTS-6) (EC 3.4.24.-)	ADAMTS6	Homo sapiens (Human)	1117		MISCELLANEOUS: [Isoform 2]: Contains critical point mutations in the region encoding the catalytic domain as well as 2 point mutations compared with genomic sequence. May either be a rare polymorphism or may have arisen through a combination of aberrant RNA editing and point mutation/sequencing error. {ECO:0000305}.	aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; extracellular matrix organization [GO:0030198]; kidney development [GO:0001822]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; extracellular matrix organization [GO:0030198]; kidney development [GO:0001822]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q9UKP6	reviewed	UR2R_HUMAN	Urotensin-2 receptor (UR-2-R) (G-protein coupled receptor 14) (Urotensin II receptor) (UR-II-R)	UTS2R GPR14	Homo sapiens (Human)	389	FUNCTION: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:14550283}.		blood circulation [GO:0008015]; blood vessel diameter maintenance [GO:0097746]; neuropeptide signaling pathway [GO:0007218]; regulation of blood pressure [GO:0008217]; signal transduction [GO:0007165]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; urotensin II receptor activity [GO:0001604]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; urotensin II receptor activity [GO:0001604]; blood circulation [GO:0008015]; blood vessel diameter maintenance [GO:0097746]; neuropeptide signaling pathway [GO:0007218]; regulation of blood pressure [GO:0008217]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9UKQ2	reviewed	ADA28_HUMAN	Disintegrin and metalloproteinase domain-containing protein 28 (ADAM 28) (EC 3.4.24.-) (Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (eMDC II) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L) (MDC-L)	ADAM28 ADAM23 MDCL	Homo sapiens (Human)	775	FUNCTION: May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.		proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	extracellular region [GO:0005576]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	extracellular region [GO:0005576]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Q9UKR0	reviewed	KLK12_HUMAN	Kallikrein-12 (EC 3.4.21.-) (Kallikrein-like protein 5) (KLK-L5)	KLK12 KLKL5 UNQ669/PRO1303	Homo sapiens (Human)	248			proteolysis [GO:0006508]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
Q9UKR5	reviewed	ERG28_HUMAN	Ergosterol biosynthetic protein 28 homolog	ERG28 C14orf1 AD-011 HSPC288 x0006	Homo sapiens (Human)	140			sterol biosynthetic process [GO:0016126]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; transport vesicle [GO:0030133]	identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; transport vesicle [GO:0030133]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; sterol biosynthetic process [GO:0016126]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9UKS6	reviewed	PACN3_HUMAN	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)	PACSIN3	Homo sapiens (Human)	424	FUNCTION: Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}.		cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of endocytosis [GO:0045806]; plasma membrane tubulation [GO:0097320]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; regulation of endocytosis [GO:0030100]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	calcium channel inhibitor activity [GO:0019855]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; calcium channel inhibitor activity [GO:0019855]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of endocytosis [GO:0045806]; plasma membrane tubulation [GO:0097320]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; regulation of endocytosis [GO:0030100]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11179684}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the inner aspect of the plasma membrane in myotubes. {ECO:0000250}.
Q9UKS7	reviewed	IKZF2_HUMAN	Zinc finger protein Helios (Ikaros family zinc finger protein 2)	IKZF2 HELIOS ZNFN1A2	Homo sapiens (Human)	526	FUNCTION: Associates with Ikaros at centromeric heterochromatin.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9UKT4	reviewed	FBX5_HUMAN	F-box only protein 5 (Early mitotic inhibitor 1)	FBXO5 EMI1 FBX5	Homo sapiens (Human)	447	FUNCTION: Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:29875408, PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase (PubMed:29875408). Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment (PubMed:29875408). As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities (PubMed:23708605, PubMed:23708001, PubMed:16921029). Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence (PubMed:17234884, PubMed:17485488, PubMed:17875940). During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (By similarity). Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (By similarity). Promotes migration and osteogenic differentiation of mesenchymal stem cells (PubMed:29850565). {ECO:0000250|UniProtKB:Q7TSG3, ECO:0000269|PubMed:16921029, ECO:0000269|PubMed:17234884, ECO:0000269|PubMed:17485488, ECO:0000269|PubMed:17875940, ECO:0000269|PubMed:23708001, ECO:0000269|PubMed:23708605, ECO:0000269|PubMed:29850565, ECO:0000269|PubMed:29875408}.		cell division [GO:0051301]; DNA damage response [GO:0006974]; microtubule polymerization [GO:0046785]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; oocyte maturation [GO:0001556]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mesenchymal stem cell migration [GO:1905322]; positive regulation of osteoblast differentiation [GO:0045669]; protein ubiquitination [GO:0016567]; regulation of DNA replication [GO:0006275]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly involved in female meiosis I [GO:0007057]; vesicle organization [GO:0016050]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	anaphase-promoting complex binding [GO:0010997]; metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; protein kinase binding [GO:0019901]; ubiquitin ligase inhibitor activity [GO:1990948]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; anaphase-promoting complex binding [GO:0010997]; metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; protein kinase binding [GO:0019901]; ubiquitin ligase inhibitor activity [GO:1990948]; cell division [GO:0051301]; DNA damage response [GO:0006974]; microtubule polymerization [GO:0046785]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; oocyte maturation [GO:0001556]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mesenchymal stem cell migration [GO:1905322]; positive regulation of osteoblast differentiation [GO:0045669]; protein ubiquitination [GO:0016567]; regulation of DNA replication [GO:0006275]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly involved in female meiosis I [GO:0007057]; vesicle organization [GO:0016050]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11988738}. Cytoplasm {ECO:0000269|PubMed:11988738}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15469984}. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration (PubMed:11988738). In mitotic cells, localizes throughout the cell, particularly at the spindle (PubMed:15469984). {ECO:0000269|PubMed:11988738, ECO:0000269|PubMed:15469984}.
Q9UKT5	reviewed	FBX4_HUMAN	F-box only protein 4	FBXO4 FBX4	Homo sapiens (Human)	387	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:18598945, PubMed:10531035, PubMed:29142209, PubMed:20181953). Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation (PubMed:18598945). Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (PubMed:16275645, PubMed:20159592). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome (PubMed:29142209). {ECO:0000269|PubMed:10531035, ECO:0000269|PubMed:16275645, ECO:0000269|PubMed:18598945, ECO:0000269|PubMed:20159592, ECO:0000269|PubMed:20181953, ECO:0000269|PubMed:29142209}.		cellular homeostasis [GO:0019725]; cellular response to ionizing radiation [GO:0071479]; cellular senescence [GO:0090398]; common myeloid progenitor cell proliferation [GO:0035726]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of telomere maintenance via telomerase [GO:0032212]; post-transcriptional regulation of gene expression [GO:0010608]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; regulation of protein stability [GO:0031647]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; telomere maintenance [GO:0000723]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]	protein homodimerization activity [GO:0042803]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; protein homodimerization activity [GO:0042803]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cellular homeostasis [GO:0019725]; cellular response to ionizing radiation [GO:0071479]; cellular senescence [GO:0090398]; common myeloid progenitor cell proliferation [GO:0035726]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of telomere maintenance via telomerase [GO:0032212]; post-transcriptional regulation of gene expression [GO:0010608]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; regulation of protein stability [GO:0031647]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; telomere maintenance [GO:0000723]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8CHQ0}.
Q9UKT7	reviewed	FBXL3_HUMAN	F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A)	FBXL3 FBL3A FBXL3A	Homo sapiens (Human)	428	FUNCTION: Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855). {ECO:0000269|PubMed:17463251, ECO:0000269|PubMed:23452855, ECO:0000269|PubMed:27565346}.		entrainment of circadian clock by photoperiod [GO:0043153]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]	ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; ubiquitin-protein transferase activity [GO:0004842]; entrainment of circadian clock by photoperiod [GO:0043153]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10531035}. Cytoplasm {ECO:0000269|PubMed:10531035}. Note=Predominantly nuclear.
Q9UKT8	reviewed	FBXW2_HUMAN	F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6)	FBXW2 FBW2 FWD2	Homo sapiens (Human)	454	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.		protein modification process [GO:0036211]; proteolysis [GO:0006508]	cytosol [GO:0005829]	ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; ubiquitin-protein transferase activity [GO:0004842]; protein modification process [GO:0036211]; proteolysis [GO:0006508]	
Q9UKT9	reviewed	IKZF3_HUMAN	Zinc finger protein Aiolos (Ikaros family zinc finger protein 3)	IKZF3 ZNFN1A3	Homo sapiens (Human)	509	FUNCTION: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:10369681, ECO:0000269|PubMed:34155405}.		B cell differentiation [GO:0030183]; mesoderm development [GO:0007498]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of B cell proliferation [GO:0030888]; regulation of lymphocyte differentiation [GO:0045619]; regulation of transcription by RNA polymerase II [GO:0006357]; response to bacterium [GO:0009617]; T cell differentiation [GO:0030217]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; B cell differentiation [GO:0030183]; mesoderm development [GO:0007498]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of B cell proliferation [GO:0030888]; regulation of lymphocyte differentiation [GO:0045619]; regulation of transcription by RNA polymerase II [GO:0006357]; response to bacterium [GO:0009617]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10369681}. Cytoplasm {ECO:0000269|PubMed:10369681}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:17646674, ECO:0000269|PubMed:34155405}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:17646674}.; SUBCELLULAR LOCATION: [Isoform 11]: Nucleus {ECO:0000269|PubMed:17646674}.; SUBCELLULAR LOCATION: [Isoform 14]: Nucleus {ECO:0000269|PubMed:17646674}. Cytoplasm {ECO:0000269|PubMed:17646674}.; SUBCELLULAR LOCATION: [Isoform 12]: Cytoplasm {ECO:0000269|PubMed:17646674}.
Q9UKU0	reviewed	ACSL6_HUMAN	Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 6) (LACS 6)	ACSL6 ACS2 FACL6 KIAA0837 LACS5	Homo sapiens (Human)	697	FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. {ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}.		acyl-CoA metabolic process [GO:0006637]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; neuroblast proliferation [GO:0007405]; very long-chain fatty acid metabolic process [GO:0000038]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]	arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; long-chain fatty acid-CoA ligase activity [GO:0004467]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]; arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; long-chain fatty acid-CoA ligase activity [GO:0004467]; protein homodimerization activity [GO:0042803]; acyl-CoA metabolic process [GO:0006637]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; neuroblast proliferation [GO:0007405]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24269233}; Single-pass type III membrane protein {ECO:0000250}.
Q9UKU6	reviewed	TRHDE_HUMAN	Thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) (TRH-degrading ectoenzyme) (EC 3.4.19.6) (Pyroglutamyl-peptidase II) (PAP-II) (TRH-specific aminopeptidase) (Thyroliberinase)	TRHDE UNQ2507/PRO5995	Homo sapiens (Human)	1024	FUNCTION: Specific inactivation of TRH after its release.		cell-cell signaling [GO:0007267]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; pyroglutamyl-peptidase activity [GO:0016920]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; pyroglutamyl-peptidase activity [GO:0016920]; zinc ion binding [GO:0008270]; cell-cell signaling [GO:0007267]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
Q9UKU7	reviewed	ACAD8_HUMAN	Isobutyryl-CoA dehydrogenase, mitochondrial (IBDH) (EC 1.3.8.5) (Activator-recruited cofactor 42 kDa component) (ARC42) (Acyl-CoA dehydrogenase family member 8) (ACAD-8)	ACAD8 ARC42 IBD	Homo sapiens (Human)	415	FUNCTION: Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway (PubMed:11013134, PubMed:12359132, PubMed:16857760). To a lesser extent, also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA (PubMed:11013134, PubMed:12359132). {ECO:0000269|PubMed:11013134, ECO:0000269|PubMed:12359132, ECO:0000269|PubMed:16857760}.		lipid metabolic process [GO:0006629]; valine catabolic process [GO:0006574]	mitochondrial matrix [GO:0005759]	acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]	mitochondrial matrix [GO:0005759]; acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; lipid metabolic process [GO:0006629]; valine catabolic process [GO:0006574]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11013134, ECO:0000269|PubMed:12359132}.
Q9UKV0	reviewed	HDAC9_HUMAN	Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR)	HDAC9 HDAC7 HDAC7B HDRP KIAA0744 MITR	Homo sapiens (Human)	1011	FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.	MISCELLANEOUS: [Isoform 3]: Major form in most tissues. Inactive due to lack of active site residues. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Excluded from the nucleus. Does not interact with ETV6. {ECO:0000305}.	B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cholesterol homeostasis [GO:0042632]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of cytokine production [GO:0001818]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of lipoprotein lipase activity [GO:0051005]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; regulation of skeletal muscle fiber development [GO:0048742]; regulation of striated muscle cell differentiation [GO:0051153]; response to amphetamine [GO:0001975]	cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; histone methyltransferase complex [GO:0035097]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone H3K14 deacetylase activity [GO:0031078]; histone H3K9 deacetylase activity [GO:0032129]; histone H4K16 deacetylase activity [GO:0034739]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; histone methyltransferase complex [GO:0035097]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone H3K14 deacetylase activity [GO:0031078]; histone H3K9 deacetylase activity [GO:0032129]; histone H4K16 deacetylase activity [GO:0034739]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cholesterol homeostasis [GO:0042632]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of cytokine production [GO:0001818]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of lipoprotein lipase activity [GO:0051005]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; regulation of skeletal muscle fiber development [GO:0048742]; regulation of striated muscle cell differentiation [GO:0051153]; response to amphetamine [GO:0001975]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9UKV3	reviewed	ACINU_HUMAN	Apoptotic chromatin condensation inducer in the nucleus (Acinus)	ACIN1 ACINUS KIAA0670	Homo sapiens (Human)	1341	FUNCTION: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}.		apoptotic chromosome condensation [GO:0030263]; erythrocyte differentiation [GO:0030218]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of apoptotic process [GO:0043065]; positive regulation of monocyte differentiation [GO:0045657]; RNA splicing [GO:0008380]	ASAP complex [GO:0061574]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP hydrolysis activity [GO:0016887]; enzyme binding [GO:0019899]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]	ASAP complex [GO:0061574]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP hydrolysis activity [GO:0016887]; enzyme binding [GO:0019899]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; apoptotic chromosome condensation [GO:0030263]; erythrocyte differentiation [GO:0030218]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of apoptotic process [GO:0043065]; positive regulation of monocyte differentiation [GO:0045657]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
Q9UKV5	reviewed	AMFR_HUMAN	E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)	AMFR RNF45	Homo sapiens (Human)	643	FUNCTION: E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676). Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767). In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569). In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676). Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353). Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408). Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303). Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303). Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327). In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation (PubMed:36593296). {ECO:0000269|PubMed:10456327, ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:12670940, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:17043353, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:23223569, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:31073040, ECO:0000269|PubMed:31953408, ECO:0000269|PubMed:36593296}.		endoplasmic reticulum unfolded protein response [GO:0030968]; learning or memory [GO:0007611]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of protein binding [GO:0032092]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; regulation of SREBP signaling pathway [GO:2000638]; signal transduction [GO:0007165]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; dendrite [GO:0030425]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]	BAT3 complex binding [GO:1904288]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor activity [GO:0038023]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytosol [GO:0005829]; dendrite [GO:0030425]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]; BAT3 complex binding [GO:1904288]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor activity [GO:0038023]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; ubiquitin-ubiquitin ligase activity [GO:0034450]; endoplasmic reticulum unfolded protein response [GO:0030968]; learning or memory [GO:0007611]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of protein binding [GO:0032092]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; regulation of SREBP signaling pathway [GO:2000638]; signal transduction [GO:0007165]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:22728137, ECO:0000269|PubMed:36593296}; Multi-pass membrane protein {ECO:0000269|PubMed:11724934}. Note=Palmitoylation promotes localization to the peripheral endoplasmic reticulum. {ECO:0000269|PubMed:22728137}.
Q9UKV8	reviewed	AGO2_HUMAN	Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)	AGO2 EIF2C2	Homo sapiens (Human)	859	FUNCTION: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446}.; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. {ECO:0000269|PubMed:34903581}.		miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of translational initiation [GO:0045947]; positive regulation of angiogenesis [GO:0045766]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of trophoblast cell migration [GO:1901165]; post-embryonic development [GO:0009791]; pre-miRNA processing [GO:0031054]; regulatory ncRNA-mediated gene silencing [GO:0031047]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]; siRNA processing [GO:0030422]; siRNA-mediated gene silencing by mRNA destabilization [GO:0090625]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mRNA cap binding complex [GO:0005845]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]	core promoter sequence-specific DNA binding [GO:0001046]; double-stranded RNA binding [GO:0003725]; endoribonuclease activity, cleaving miRNA-paired mRNA [GO:0090624]; endoribonuclease activity, cleaving siRNA-paired mRNA [GO:0070551]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA cap binding [GO:0098808]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA polymerase II complex binding [GO:0000993]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mRNA cap binding complex [GO:0005845]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]; core promoter sequence-specific DNA binding [GO:0001046]; double-stranded RNA binding [GO:0003725]; endoribonuclease activity, cleaving miRNA-paired mRNA [GO:0090624]; endoribonuclease activity, cleaving siRNA-paired mRNA [GO:0070551]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA cap binding [GO:0098808]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA polymerase II complex binding [GO:0000993]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; translation initiation factor activity [GO:0003743]; miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of translational initiation [GO:0045947]; positive regulation of angiogenesis [GO:0045766]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of trophoblast cell migration [GO:1901165]; post-embryonic development [GO:0009791]; pre-miRNA processing [GO:0031054]; regulatory ncRNA-mediated gene silencing [GO:0031047]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]; siRNA processing [GO:0030422]; siRNA-mediated gene silencing by mRNA destabilization [GO:0090625]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:23125361, ECO:0000269|PubMed:23603119, ECO:0000269|PubMed:33199684}. Nucleus {ECO:0000269|PubMed:23125361}. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8.
Q9UKW4	reviewed	VAV3_HUMAN	Guanine nucleotide exchange factor VAV3 (VAV-3)	VAV3	Homo sapiens (Human)	847	FUNCTION: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 3]: May be produced by alternative promoter usage. {ECO:0000305}.	angiogenesis [GO:0001525]; B cell receptor signaling pathway [GO:0050853]; cell migration [GO:0016477]; DNA damage response [GO:0006974]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; integrin-mediated signaling pathway [GO:0007229]; lamellipodium assembly [GO:0030032]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell adhesion [GO:0045785]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to xenobiotic stimulus [GO:0009410]; small GTPase mediated signal transduction [GO:0007264]; vesicle fusion [GO:0006906]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]	epidermal growth factor receptor binding [GO:0005154]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; epidermal growth factor receptor binding [GO:0005154]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; angiogenesis [GO:0001525]; B cell receptor signaling pathway [GO:0050853]; cell migration [GO:0016477]; DNA damage response [GO:0006974]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; integrin-mediated signaling pathway [GO:0007229]; lamellipodium assembly [GO:0030032]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell adhesion [GO:0045785]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to xenobiotic stimulus [GO:0009410]; small GTPase mediated signal transduction [GO:0007264]; vesicle fusion [GO:0006906]	
Q9UKW6	reviewed	ELF5_HUMAN	ETS-related transcription factor Elf-5 (E74-like factor 5) (Epithelium-restricted ESE-1-related Ets factor) (Epithelium-specific Ets transcription factor 2) (ESE-2)	ELF5 ESE2	Homo sapiens (Human)	265	FUNCTION: Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. {ECO:0000269|PubMed:10506207}.; FUNCTION: Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters. {ECO:0000269|PubMed:10506207}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
Q9UKX2	reviewed	MYH2_HUMAN	Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)	MYH2 MYHSA2	Homo sapiens (Human)	1941	FUNCTION: Muscle contraction. Required for cytoskeleton organization (By similarity). {ECO:0000250}.		muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]	SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Q9UKX3	reviewed	MYH13_HUMAN	Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin)	MYH13	Homo sapiens (Human)	1938	FUNCTION: Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}.		cellular response to starvation [GO:0009267]; muscle contraction [GO:0006936]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; cellular response to starvation [GO:0009267]; muscle contraction [GO:0006936]	SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Q9UKX5	reviewed	ITA11_HUMAN	Integrin alpha-11	ITGA11 MSTP018	Homo sapiens (Human)	1188	FUNCTION: Integrin alpha-11/beta-1 is a receptor for collagen.		cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; collagen-activated signaling pathway [GO:0038065]; integrin-mediated signaling pathway [GO:0007229]; muscle organ development [GO:0007517]; osteoblast differentiation [GO:0001649]; substrate-dependent cell migration [GO:0006929]	external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alpha11-beta1 complex [GO:0034681]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]	collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; collagen receptor activity [GO:0038064]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]	external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alpha11-beta1 complex [GO:0034681]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; collagen receptor activity [GO:0038064]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; collagen-activated signaling pathway [GO:0038065]; integrin-mediated signaling pathway [GO:0007229]; muscle organ development [GO:0007517]; osteoblast differentiation [GO:0001649]; substrate-dependent cell migration [GO:0006929]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9UKX7	reviewed	NUP50_HUMAN	Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)	NUP50 NPAP60L PRO1146	Homo sapiens (Human)	468	FUNCTION: Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}.	MISCELLANEOUS: [Isoform 2]: Contrarily to Npap60L, Npap60S does not displaces NLSs, but stabilizes their binding to importin-alpha. {ECO:0000305}.	mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]	nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]		nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:12802065}. Nucleus membrane {ECO:0000250|UniProtKB:O08587}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08587}; Nucleoplasmic side {ECO:0000250|UniProtKB:O08587}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis (PubMed:12802065). Associates with the newly formed nuclear membrane during telophase (PubMed:12802065). In the testis, the localization changes during germ cell differentiation from the nuclear surface in spermatocytes to the whole nucleus (interior) in spermatids and back to the nuclear surface in spermatozoa (By similarity). {ECO:0000250|UniProtKB:O08587, ECO:0000269|PubMed:12802065}.
Q9UKY0	reviewed	PRND_HUMAN	Prion-like protein doppel (PrPLP) (Prion protein 2)	PRND DPL UNQ1830/PRO3443	Homo sapiens (Human)	176	FUNCTION: Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (PubMed:15218028, PubMed:20411530). {ECO:0000250|UniProtKB:Q9QUG3, ECO:0000269|PubMed:15218028, ECO:0000269|PubMed:20411530}.		acrosome reaction [GO:0007340]; intracellular copper ion homeostasis [GO:0006878]; protein homooligomerization [GO:0051260]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	copper ion binding [GO:0005507]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; copper ion binding [GO:0005507]; acrosome reaction [GO:0007340]; intracellular copper ion homeostasis [GO:0006878]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12200435, ECO:0000269|PubMed:15218028}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12200435}.
Q9UKY1	reviewed	ZHX1_HUMAN	Zinc fingers and homeoboxes protein 1	ZHX1	Homo sapiens (Human)	873	FUNCTION: Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}.		cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12237128, ECO:0000269|PubMed:17056598}. Note=Colocalized in the nucleus with DNMT3B.
Q9UKY4	reviewed	POMT2_HUMAN	Protein O-mannosyl-transferase 2 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 2)	POMT2	Homo sapiens (Human)	750	FUNCTION: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:14699049, PubMed:28512129). Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129). {ECO:0000269|PubMed:14699049, ECO:0000269|PubMed:28512129}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	basement membrane organization [GO:0071711]; dentate gyrus development [GO:0021542]; positive regulation of protein O-linked glycosylation [GO:1904100]; protein O-linked mannosylation [GO:0035269]; reactive gliosis [GO:0150103]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]; metal ion binding [GO:0046872]; basement membrane organization [GO:0071711]; dentate gyrus development [GO:0021542]; positive regulation of protein O-linked glycosylation [GO:1904100]; protein O-linked mannosylation [GO:0035269]; reactive gliosis [GO:0150103]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12460945, ECO:0000269|PubMed:14699049}; Multi-pass membrane protein {ECO:0000269|PubMed:12460945, ECO:0000269|PubMed:14699049}.
Q9UKZ4	reviewed	TEN1_HUMAN	Teneurin-1 (Ten-1) (Protein Odd Oz/ten-m homolog 1) (Tenascin-M1) (Ten-m1) (Teneurin transmembrane protein 1) [Cleaved into: Ten-1 intracellular domain (IDten-1) (Ten-1 ICD); Teneurin C-terminal-associated peptide (TCPA-1) (Ten-1 extracellular domain) (Ten-1 ECD)]	TENM1 ODZ1 TNM1	Homo sapiens (Human)	2725	FUNCTION: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). {ECO:0000250}.; FUNCTION: [Teneurin C-terminal-associated peptide]: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity). {ECO:0000250}.; FUNCTION: [Ten-1 intracellular domain]: Induces gene transcription activation. {ECO:0000250}.	MISCELLANEOUS: [Teneurin C-terminal-associated peptide]: Binds to the plasma membrane and may be internalized by a receptor- and caveolae-mediated endocytosis manner to reach cytosolic compartments in a dynamin-dependent manner. {ECO:0000250}.	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neuropeptide signaling pathway [GO:0007218]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of transcription by RNA polymerase III [GO:0006359]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cell adhesion molecule binding [GO:0050839]; heparin binding [GO:0008201]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; heparin binding [GO:0008201]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neuropeptide signaling pathway [GO:0007218]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of transcription by RNA polymerase III [GO:0006359]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Ten-1 intracellular domain]: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.; SUBCELLULAR LOCATION: [Teneurin C-terminal-associated peptide]: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus (By similarity). {ECO:0000250}.
Q9UKZ9	reviewed	PCOC2_HUMAN	Procollagen C-endopeptidase enhancer 2 (Procollagen COOH-terminal proteinase enhancer 2) (PCPE-2) (Procollagen C-proteinase enhancer 2)	PCOLCE2 PCPE2 UNQ250/PRO287	Homo sapiens (Human)	415	FUNCTION: Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1. {ECO:0000269|PubMed:12393877}.		cellular response to leukemia inhibitory factor [GO:1990830]	extracellular region [GO:0005576]	collagen binding [GO:0005518]; heparin binding [GO:0008201]; peptidase activator activity [GO:0016504]	extracellular region [GO:0005576]; collagen binding [GO:0005518]; heparin binding [GO:0008201]; peptidase activator activity [GO:0016504]; cellular response to leukemia inhibitory factor [GO:1990830]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9UL01	reviewed	DSE_HUMAN	Dermatan-sulfate epimerase (DS epimerase) (EC 5.1.3.19) (Chondroitin-glucuronate 5-epimerase) (Squamous cell carcinoma antigen recognized by T-cells 2) (SART-2)	DSE SART2	Homo sapiens (Human)	958	FUNCTION: Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate. {ECO:0000269|PubMed:16505484, ECO:0000269|PubMed:19004833, ECO:0000269|PubMed:7092807, ECO:0000269|Ref.7}.		chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate metabolic process [GO:0030204]; dermatan sulfate biosynthetic process [GO:0030208]; dermatan sulfate metabolic process [GO:0030205]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]	cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	chondroitin-glucuronate 5-epimerase activity [GO:0047757]; metal ion binding [GO:0046872]	cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; chondroitin-glucuronate 5-epimerase activity [GO:0047757]; metal ion binding [GO:0046872]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate metabolic process [GO:0030204]; dermatan sulfate biosynthetic process [GO:0030208]; dermatan sulfate metabolic process [GO:0030205]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679095, ECO:0000305|PubMed:7092807}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:10679095}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10679095}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000269|PubMed:7092807}; Multi-pass membrane protein {ECO:0000305}.
Q9UL03	reviewed	INT6_HUMAN	Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26) (Protein deleted in cancer 1) (DICE1)	INTS6 DBI1 DDX26 DDX26A	Homo sapiens (Human)	887	FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144). {ECO:0000269|PubMed:15254679, ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.		regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	actin cytoskeleton [GO:0015629]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transmembrane signaling receptor activity [GO:0004888]	actin cytoskeleton [GO:0015629]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transmembrane signaling receptor activity [GO:0004888]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11939413, ECO:0000269|PubMed:23904267}.
Q9UL12	reviewed	SARDH_HUMAN	Sarcosine dehydrogenase, mitochondrial (SarDH) (EC 1.5.8.3) (BPR-2)	SARDH DMGDHL1	Homo sapiens (Human)	918	FUNCTION: Catalyzes the last step of the oxidative degradation of choline to glycine. Converts sarcosine into glycine. {ECO:0000250|UniProtKB:Q64380}.		sarcosine catabolic process [GO:1901053]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	sarcosine dehydrogenase activity [GO:0008480]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; sarcosine dehydrogenase activity [GO:0008480]; sarcosine catabolic process [GO:1901053]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q64380}.
Q9UL15	reviewed	BAG5_HUMAN	BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5)	BAG5 KIAA0873	Homo sapiens (Human)	447	FUNCTION: Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (PubMed:20223214). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). {ECO:0000250|UniProtKB:Q5QJC9, ECO:0000250|UniProtKB:Q8CI32, ECO:0000269|PubMed:20223214}.		Golgi organization [GO:0007030]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein refolding [GO:0061084]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of inclusion body assembly [GO:0090083]; regulation of ubiquitin-protein transferase activity [GO:0051438]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; junctional membrane complex [GO:0030314]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	adenyl-nucleotide exchange factor activity [GO:0000774]; protein kinase binding [GO:0019901]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; junctional membrane complex [GO:0030314]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; adenyl-nucleotide exchange factor activity [GO:0000774]; protein kinase binding [GO:0019901]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625]; Golgi organization [GO:0007030]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein refolding [GO:0061084]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of inclusion body assembly [GO:0090083]; regulation of ubiquitin-protein transferase activity [GO:0051438]	SUBCELLULAR LOCATION: Note=In cardiomyocytes, localized at specialized membrane contact sites between T-tubules and the sarcoplasmic reticulum, known as junctional membrane complexes. {ECO:0000250|UniProtKB:Q8CI32}.
Q9UL16	reviewed	CFA45_HUMAN	Cilia- and flagella-associated protein 45 (Coiled-coil domain-containing protein 19) (Nasopharyngeal epithelium-specific protein 1)	CFAP45 CCDC19 NESG1	Homo sapiens (Human)	551	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). It is an AMP-binding protein that may facilitate dynein ATPase-dependent ciliary and flagellar beating via adenine nucleotide homeostasis. May function as a donor of AMP to AK8 and hence promote ADP production (PubMed:33139725). {ECO:0000250|UniProtKB:Q32LN4, ECO:0000269|PubMed:33139725, ECO:0000269|PubMed:36191189}.		cerebrospinal fluid circulation [GO:0090660]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]	9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	AMP binding [GO:0016208]	9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; AMP binding [GO:0016208]; cerebrospinal fluid circulation [GO:0090660]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:33139725, ECO:0000269|PubMed:36191189}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:33139725}. Note=Located in the proximal region of respiratory cilia. {ECO:0000269|PubMed:33139725}.
Q9UL17	reviewed	TBX21_HUMAN	T-box transcription factor TBX21 (T-box protein 21) (T-cell-specific T-box transcription factor T-bet) (Transcription factor TBLYM)	TBX21 TBET TBLYM	Homo sapiens (Human)	535	FUNCTION: Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Induces permissive chromatin accessibilty and CpG methylation in IFNG (PubMed:33296702). Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity). Required for the correct development of natural killer (NK) and mucosal-associated invariant T (MAIT) cells (PubMed:33296702). {ECO:0000250|UniProtKB:Q9JKD8, ECO:0000269|PubMed:10761931, ECO:0000269|PubMed:27292648, ECO:0000269|PubMed:33296702}.		cell fate specification [GO:0001708]; cellular response to organic substance [GO:0071310]; lymphocyte migration [GO:0072676]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of T cell differentiation [GO:0045580]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]; T-helper 1 cell lineage commitment [GO:0002296]	neuronal cell body [GO:0043025]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	neuronal cell body [GO:0043025]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; cell fate specification [GO:0001708]; cellular response to organic substance [GO:0071310]; lymphocyte migration [GO:0072676]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of T cell differentiation [GO:0045580]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]; T-helper 1 cell lineage commitment [GO:0002296]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:33296702}.
Q9UL18	reviewed	AGO1_HUMAN	Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99)	AGO1 EIF2C1	Homo sapiens (Human)	857	FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:18771919}.	MISCELLANEOUS: Lacks RNA cleavage activity due to the absence of the conserved His at position 805, but also because it binds the RNA in a subtly different manner that precludes efficient cleavage.	miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of angiogenesis [GO:0016525]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pre-miRNA processing [GO:0031054]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]	core promoter sequence-specific DNA binding [GO:0001046]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; single-stranded RNA binding [GO:0003727]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]; core promoter sequence-specific DNA binding [GO:0001046]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; single-stranded RNA binding [GO:0003727]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of angiogenesis [GO:0016525]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pre-miRNA processing [GO:0031054]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:20616046}.
Q9UL19	reviewed	PLAT4_HUMAN	Phospholipase A and acyltransferase 4 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 4) (HRSL4) (RAR-responsive protein TIG3) (Retinoic acid receptor responder protein 3) (Retinoid-inducible gene 1 protein) (Tazarotene-induced gene 3 protein)	PLAAT4 RARRES3 RIG1 TIG3	Homo sapiens (Human)	164	FUNCTION: Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852). Promotes keratinocyte differentiation via activation of TGM1 (PubMed:17762858). {ECO:0000269|PubMed:17762858, ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:22605381, ECO:0000269|PubMed:22825852, ECO:0000303|PubMed:26503625}.		lipid catabolic process [GO:0016042]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; negative regulation of cell population proliferation [GO:0008285]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phospholipid metabolic process [GO:0006644]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of protein-glutamine gamma-glutamyltransferase activity [GO:0150074]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; acyltransferase activity [GO:0016746]; N-acyltransferase activity [GO:0016410]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; acyltransferase activity [GO:0016746]; N-acyltransferase activity [GO:0016410]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]; lipid catabolic process [GO:0016042]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; negative regulation of cell population proliferation [GO:0008285]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phospholipid metabolic process [GO:0006644]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of protein-glutamine gamma-glutamyltransferase activity [GO:0150074]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17762858}; Single-pass membrane protein {ECO:0000255}.
Q9UL25	reviewed	RAB21_HUMAN	Ras-related protein Rab-21	RAB21 KIAA0118	Homo sapiens (Human)	225	FUNCTION: Small GTPase involved in membrane trafficking control (PubMed:18804435, PubMed:25648148). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601). {ECO:0000250|UniProtKB:P35282, ECO:0000250|UniProtKB:Q6AXT5, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:25648148, ECO:0000269|PubMed:31455601}.		anterograde axonal transport [GO:0008089]; intracellular protein transport [GO:0006886]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein stabilization [GO:0050821]; Rab protein signal transduction [GO:0032482]; regulation of axon extension [GO:0030516]; regulation of exocytosis [GO:0017157]	axon cytoplasm [GO:1904115]; cleavage furrow [GO:0032154]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; vesicle membrane [GO:0012506]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	axon cytoplasm [GO:1904115]; cleavage furrow [GO:0032154]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; vesicle membrane [GO:0012506]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; anterograde axonal transport [GO:0008089]; intracellular protein transport [GO:0006886]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein stabilization [GO:0050821]; Rab protein signal transduction [GO:0032482]; regulation of axon extension [GO:0030516]; regulation of exocytosis [GO:0017157]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10887961}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19745841}. Golgi apparatus membrane {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:16525121, ECO:0000269|PubMed:25648148}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10887961}. Cleavage furrow {ECO:0000269|PubMed:18804435}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P35282}. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961). During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435). In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435). {ECO:0000250|UniProtKB:P35282, ECO:0000269|PubMed:10887961, ECO:0000269|PubMed:18804435}.
Q9UL26	reviewed	RB22A_HUMAN	Ras-related protein Rab-22A (Rab-22)	RAB22A RAB22	Homo sapiens (Human)	194	FUNCTION: Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905). {ECO:0000269|PubMed:16537905, ECO:0000269|PubMed:21849477}.		endocytosis [GO:0006897]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; regulation of vesicle size [GO:0097494]	actin cytoskeleton [GO:0015629]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	actin cytoskeleton [GO:0015629]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; regulation of vesicle size [GO:0097494]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:P51154}; Lipid-anchor {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P51154}; Lipid-anchor {ECO:0000305}. Early endosome {ECO:0000269|PubMed:16537905}. Late endosome {ECO:0000250|UniProtKB:P51154}. Cell projection, ruffle {ECO:0000269|PubMed:21419809}. Cytoplasmic vesicle {ECO:0000269|PubMed:21419809}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269|PubMed:21255211}.
Q9UL33	reviewed	TPC2L_HUMAN	Trafficking protein particle complex subunit 2-like protein	TRAPPC2L HSPC126	Homo sapiens (Human)	140	FUNCTION: Plays a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000269|PubMed:19416478, ECO:0000269|PubMed:30120216}.		COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:19416478}. Endoplasmic reticulum {ECO:0000269|PubMed:19416478}. Golgi apparatus {ECO:0000269|PubMed:19416478}.
Q9UL40	reviewed	ZN346_HUMAN	Zinc finger protein 346 (Just another zinc finger protein)	ZNF346 JAZ	Homo sapiens (Human)	294	FUNCTION: Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:24521053, ECO:0000269|PubMed:28431233}.			cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15254228}. Cytoplasm {ECO:0000269|PubMed:15254228}. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.
Q9UL41	reviewed	PNMA3_HUMAN	Paraneoplastic antigen Ma3	PNMA3 MA3	Homo sapiens (Human)	463		MISCELLANEOUS: Antibodies against PNMA3 are present in sera from patients suffering of paraneoplastic neurological disorders.	positive regulation of apoptotic process [GO:0043065]	nucleolus [GO:0005730]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
Q9UL42	reviewed	PNMA2_HUMAN	Paraneoplastic antigen Ma2 (40 kDa neuronal protein) (Onconeuronal antigen Ma2) (Paraneoplastic neuronal antigen MM2)	PNMA2 KIAA0883 MA2	Homo sapiens (Human)	364		MISCELLANEOUS: Antibodies against PNMA2 are present in sera from patients suffering of paraneoplastic neurological disorders.	positive regulation of apoptotic process [GO:0043065]	nucleolus [GO:0005730]		nucleolus [GO:0005730]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10050892}.
Q9UL45	reviewed	BL1S6_HUMAN	Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (Pallidin) (Syntaxin 13-interacting protein)	BLOC1S6 PA PLDN	Homo sapiens (Human)	172	FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:21998198}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to exons 2 and 3 skipping. {ECO:0000305}.	anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; endosome to melanosome transport [GO:0035646]; intracellular transport [GO:0046907]; melanocyte differentiation [GO:0030318]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; membrane fusion [GO:0061025]; neuron projection development [GO:0031175]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of pigment cell differentiation [GO:0050942]; secretion of lysosomal enzymes [GO:0033299]; synaptic vesicle docking [GO:0016081]	axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; membrane [GO:0016020]; membrane-bounded organelle [GO:0043227]; presynapse [GO:0098793]; transport vesicle [GO:0030133]	actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905]	axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; membrane [GO:0016020]; membrane-bounded organelle [GO:0043227]; presynapse [GO:0098793]; transport vesicle [GO:0030133]; actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; endosome to melanosome transport [GO:0035646]; intracellular transport [GO:0046907]; melanocyte differentiation [GO:0030318]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; membrane fusion [GO:0061025]; neuron projection development [GO:0031175]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of pigment cell differentiation [GO:0050942]; secretion of lysosomal enzymes [GO:0033299]; synaptic vesicle docking [GO:0016081]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12019270, ECO:0000269|PubMed:12191018}. Membrane {ECO:0000269|PubMed:12019270, ECO:0000269|PubMed:12191018}; Peripheral membrane protein {ECO:0000269|PubMed:12019270}. Note=It can exist as a soluble protein as well as a peripheral membrane protein (PubMed:12019270). {ECO:0000269|PubMed:12019270}.
Q9UL46	reviewed	PSME2_HUMAN	Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta)	PSME2	Homo sapiens (Human)	239	FUNCTION: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.		regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]	endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]; endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136]	
Q9UL49	reviewed	TCFL5_HUMAN	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1)	TCFL5 CHA E2BP1	Homo sapiens (Human)	500	FUNCTION: Putative transcription factor. Isoform 3 may play a role in early spermatogenesis. {ECO:0000269|PubMed:9763657}.	MISCELLANEOUS: Antibodies against TCFL5 are present in sera from patients with Chagas disease (also called American Trypanosomiasis), a disease caused by Trypanosoma cruzi. Two different epitopes that mimic Trypanosoma cruzi antigens have been identified: R1 and R3 epitopes, which are recognized by T- and B-cells, respectively.	cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:9763657}.
Q9UL51	reviewed	HCN2_HUMAN	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2)	HCN2 BCNG2	Homo sapiens (Human)	889	FUNCTION: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). {ECO:0000250, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219}.	MISCELLANEOUS: Inhibited by extracellular cesium ions.	cell-cell signaling [GO:0007267]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]	axon [GO:0030424]; dendrite [GO:0030425]; HCN channel complex [GO:0098855]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	cAMP binding [GO:0030552]; identical protein binding [GO:0042802]; intracellular cAMP-activated cation channel activity [GO:0005222]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]	axon [GO:0030424]; dendrite [GO:0030425]; HCN channel complex [GO:0098855]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; cAMP binding [GO:0030552]; identical protein binding [GO:0042802]; intracellular cAMP-activated cation channel activity [GO:0005222]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]; cell-cell signaling [GO:0007267]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219}; Multi-pass membrane protein {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219}.
Q9UL52	reviewed	TM11E_HUMAN	Transmembrane protease serine 11E (EC 3.4.21.-) (Serine protease DESC1) (Transmembrane protease serine 11E2) [Cleaved into: Transmembrane protease serine 11E non-catalytic chain; Transmembrane protease serine 11E catalytic chain]	TMPRSS11E DESC1 TMPRSS11E2 UNQ742/PRO1461	Homo sapiens (Human)	423	FUNCTION: Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. {ECO:0000250|UniProtKB:Q5S248}.		cognition [GO:0050890]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; cognition [GO:0050890]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5S248}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q5S248}.; SUBCELLULAR LOCATION: [Transmembrane protease serine 11E catalytic chain]: Secreted {ECO:0000250|UniProtKB:Q5S248}. Note=Activated by cleavage and secreted. {ECO:0000250|UniProtKB:Q5S248}.
Q9UL54	reviewed	TAOK2_HUMAN	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2)	TAOK2 KIAA0881 MAP3K17 PSK PSK1 UNQ2971/PRO7431	Homo sapiens (Human)	1235	FUNCTION: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}.		actin cytoskeleton organization [GO:0030036]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; basal dendrite arborization [GO:0150020]; basal dendrite morphogenesis [GO:0150019]; cell migration [GO:0016477]; DNA damage response [GO:0006974]; focal adhesion assembly [GO:0048041]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein targeting to membrane [GO:0006612]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360]; stress-activated MAPK cascade [GO:0051403]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; neuropilin binding [GO:0038191]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; neuropilin binding [GO:0038191]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; actin cytoskeleton organization [GO:0030036]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; basal dendrite arborization [GO:0150020]; basal dendrite morphogenesis [GO:0150019]; cell migration [GO:0016477]; DNA damage response [GO:0006974]; focal adhesion assembly [GO:0048041]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein targeting to membrane [GO:0006612]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360]; stress-activated MAPK cascade [GO:0051403]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton. Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cell projection, dendrite. Note=In dendrites, colocalizes with PCDH8. {ECO:0000250}.
Q9UL62	reviewed	TRPC5_HUMAN	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (TRP-5) (hTRP-5) (hTRP5)	TRPC5 TRP5	Homo sapiens (Human)	973	FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). {ECO:0000250|UniProtKB:Q9QX29, ECO:0000269|PubMed:16284075}.		calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; negative regulation of dendrite morphogenesis [GO:0050774]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]; positive regulation of axon extension [GO:0045773]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of membrane hyperpolarization [GO:1902630]	calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; dendrite [GO:0030425]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; actinin binding [GO:0042805]; ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; clathrin binding [GO:0030276]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]	calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; dendrite [GO:0030425]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; actinin binding [GO:0042805]; ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; clathrin binding [GO:0030276]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; negative regulation of dendrite morphogenesis [GO:0050774]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]; positive regulation of axon extension [GO:0045773]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of membrane hyperpolarization [GO:1902630]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16284075}; Multi-pass membrane protein {ECO:0000269|PubMed:16284075}.
Q9UL63	reviewed	MKLN1_HUMAN	Muskelin	MKLN1	Homo sapiens (Human)	735	FUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (By similarity). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (PubMed:18710924). {ECO:0000250|UniProtKB:O89050, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972}.		actin cytoskeleton organization [GO:0030036]; cell-matrix adhesion [GO:0007160]; regulation of cell shape [GO:0008360]; regulation of receptor internalization [GO:0002090]; signal transduction [GO:0007165]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; ruffle [GO:0001726]; ubiquitin ligase complex [GO:0000151]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; ruffle [GO:0001726]; ubiquitin ligase complex [GO:0000151]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; actin cytoskeleton organization [GO:0030036]; cell-matrix adhesion [GO:0007160]; regulation of cell shape [GO:0008360]; regulation of receptor internalization [GO:0002090]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17467196}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O89050}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:O89050}. Cell projection, ruffle {ECO:0000250|UniProtKB:O89050}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:O89050}. Synapse {ECO:0000250|UniProtKB:O89050}. Postsynapse {ECO:0000250|UniProtKB:O89050}. Note=Colocalizes with GABRA1 at synapses and in postsynaptic regions. Colocalizes with actin fibers in the cell cortex. {ECO:0000250|UniProtKB:O89050}.
Q9UL68	reviewed	MYT1L_HUMAN	Myelin transcription factor 1-like protein (MyT1-L) (MyT1L)	MYT1L KIAA1106	Homo sapiens (Human)	1186	FUNCTION: Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes. {ECO:0000250|UniProtKB:P97500}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; zinc ion binding [GO:0008270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P97500}. Chromosome {ECO:0000250|UniProtKB:P97500}. Note=Preferentially binds to DNA binding sites that are in an open chromatin configuration. {ECO:0000250|UniProtKB:P97500}.
Q9ULA0	reviewed	DNPEP_HUMAN	Aspartyl aminopeptidase (EC 3.4.11.21)	DNPEP ASPEP DAP	Homo sapiens (Human)	485	FUNCTION: Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism. {ECO:0000269|PubMed:9632644}.		peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9632644}.
Q9ULB1	reviewed	NRX1A_HUMAN	Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha)	NRXN1 KIAA0578	Homo sapiens (Human)	1477	FUNCTION: Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may affect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom. {ECO:0000250|UniProtKB:Q9CS84}.	MISCELLANEOUS: [Isoform 2a]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3a]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Produced by alternative promoter usage and alternative splicing. {ECO:0000305}.	adult behavior [GO:0030534]; axon guidance [GO:0007411]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; learning [GO:0007612]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter secretion [GO:0007269]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]	cell projection [GO:0042995]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; vesicle [GO:0031982]	acetylcholine receptor binding [GO:0033130]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; neuroligin family protein binding [GO:0097109]; signaling receptor activity [GO:0038023]	cell projection [GO:0042995]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; vesicle [GO:0031982]; acetylcholine receptor binding [GO:0033130]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; neuroligin family protein binding [GO:0097109]; signaling receptor activity [GO:0038023]; adult behavior [GO:0030534]; axon guidance [GO:0007411]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; learning [GO:0007612]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter secretion [GO:0007269]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9CS84}; Single-pass type I membrane protein {ECO:0000305}.
Q9ULB4	reviewed	CADH9_HUMAN	Cadherin-9	CDH9	Homo sapiens (Human)	789	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9ULC0	reviewed	MUCEN_HUMAN	Endomucin (Endomucin-2) (Gastric cancer antigen Ga34) (Mucin-14) (MUC-14)	EMCN EMCN2 MUC14	Homo sapiens (Human)	261	FUNCTION: Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.		hematopoietic stem cell homeostasis [GO:0061484]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; hematopoietic stem cell homeostasis [GO:0061484]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Consistently localized to the plasma membrane and less abundantly to Golgi-like perinuclear stacks.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q9ULC3	reviewed	RAB23_HUMAN	Ras-related protein Rab-23	RAB23 HSPC137	Homo sapiens (Human)	237	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. {ECO:0000269|PubMed:22365972, ECO:0000269|PubMed:22452336}.		autophagosome assembly [GO:0000045]; cellular defense response [GO:0006968]; cilium assembly [GO:0060271]; craniofacial suture morphogenesis [GO:0097094]; GTP metabolic process [GO:0046039]; intracellular protein transport [GO:0006886]; negative regulation of protein import into nucleus [GO:0042308]	autophagosome [GO:0005776]; cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	autophagosome [GO:0005776]; cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagosome assembly [GO:0000045]; cellular defense response [GO:0006968]; cilium assembly [GO:0060271]; craniofacial suture morphogenesis [GO:0097094]; GTP metabolic process [GO:0046039]; intracellular protein transport [GO:0006886]; negative regulation of protein import into nucleus [GO:0042308]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P35288}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000250|UniProtKB:P35288}. Cytoplasm {ECO:0000269|PubMed:22365972}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:22452336}. Endosome membrane {ECO:0000250, ECO:0000250|UniProtKB:P35288}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269|PubMed:21255211}.
Q9ULC4	reviewed	MCTS1_HUMAN	Malignant T-cell-amplified sequence 1 (MCT-1) (Multiple copies T-cell malignancies)	MCTS1 MCT1	Homo sapiens (Human)	181	FUNCTION: Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269|PubMed:10440924, ECO:0000269|PubMed:11709712, ECO:0000269|PubMed:12637315, ECO:0000269|PubMed:15897892, ECO:0000269|PubMed:16322206, ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:17016429, ECO:0000269|PubMed:17416211, ECO:0000269|PubMed:20713520, ECO:0000269|PubMed:9766643}.		cell cycle [GO:0007049]; DNA damage response [GO:0006974]; formation of translation preinitiation complex [GO:0001731]; IRES-dependent viral translational initiation [GO:0075522]; positive regulation of cell population proliferation [GO:0008284]; ribosome disassembly [GO:0032790]	cytoplasm [GO:0005737]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; cell cycle [GO:0007049]; DNA damage response [GO:0006974]; formation of translation preinitiation complex [GO:0001731]; IRES-dependent viral translational initiation [GO:0075522]; positive regulation of cell population proliferation [GO:0008284]; ribosome disassembly [GO:0032790]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11709712, ECO:0000269|PubMed:16982740}. Note=Nuclear relocalization after DNA damage.
Q9ULC5	reviewed	ACSL5_HUMAN	Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 5) (LACS 5)	ACSL5 ACS5 FACL5 UNQ633/PRO1250	Homo sapiens (Human)	683	FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. {ECO:0000250, ECO:0000269|PubMed:17681178, ECO:0000269|PubMed:18806831, ECO:0000269|PubMed:19459852, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}.	MISCELLANEOUS: [Isoform 1]: Localize in mitochondrion and endoplasmic reticulum.; MISCELLANEOUS: [Isoform 3]: Localize in mitochondrion and endoplasmic reticulum. {ECO:0000305}.	long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of long-chain fatty acid import across plasma membrane [GO:0010747]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of long-chain fatty acid import across plasma membrane [GO:0010747]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:17681178}. Endoplasmic reticulum {ECO:0000269|PubMed:17681178, ECO:0000269|PubMed:24269233}. Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:24269233}.
Q9ULC6	reviewed	PADI1_HUMAN	Protein-arginine deiminase type-1 (EC 3.5.3.15) (Peptidylarginine deiminase I) (Protein-arginine deiminase type I)	PADI1 PAD1 PDI1	Homo sapiens (Human)	663	FUNCTION: Catalyzes the deimination of arginine residues of proteins. {ECO:0000269|PubMed:12416996, ECO:0000269|PubMed:27393304, ECO:0000269|PubMed:30044909}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; protein-arginine deiminase activity [GO:0004668]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; protein-arginine deiminase activity [GO:0004668]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12416996}.
Q9ULC8	reviewed	ZDHC8_HUMAN	Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378)	ZDHHC8 KIAA1292 ZDHHCL1 ZNF378	Homo sapiens (Human)	765	FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}.	MISCELLANEOUS: According to initial studies, defects in ZDHHC8 may contribute to susceptibility to schizophrenia (PubMed:15489219, PubMed:15184899). However, additional studies could not confirm this (PubMed:15992527, PubMed:15631889, PubMed:16150541). {ECO:0000269|PubMed:15184899, ECO:0000269|PubMed:15489219, ECO:0000269|PubMed:15631889, ECO:0000269|PubMed:15992527, ECO:0000269|PubMed:16150541}.	high-density lipoprotein particle assembly [GO:0034380]; locomotory behavior [GO:0007626]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation by host of viral process [GO:0044794]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein palmitoylation [GO:0018345]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrial membrane [GO:0031966]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrial membrane [GO:0031966]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; high-density lipoprotein particle assembly [GO:0034380]; locomotory behavior [GO:0007626]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation by host of viral process [GO:0044794]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein palmitoylation [GO:0018345]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16647879, ECO:0000269|PubMed:26535572, ECO:0000269|PubMed:34599882}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q5Y5T5}; Multi-pass membrane protein {ECO:0000255}.
Q9ULD0	reviewed	OGDHL_HUMAN	2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like)	OGDHL KIAA1290	Homo sapiens (Human)	1010	FUNCTION: 2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH (By similarity). The OGDHC complex is mainly active in the mitochondrion (By similarity). Involved in the inhibition of cell proliferation and in apoptosis (PubMed:23152800, PubMed:31175094). {ECO:0000250|UniProtKB:D3ZQD3, ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:31175094}.		2-oxoglutarate metabolic process [GO:0006103]; glycolytic process [GO:0006096]; tricarboxylic acid cycle [GO:0006099]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252]	metal ion binding [GO:0046872]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252]; metal ion binding [GO:0046872]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976]; 2-oxoglutarate metabolic process [GO:0006103]; glycolytic process [GO:0006096]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:23152800}.
Q9ULD2	reviewed	MTUS1_HUMAN	Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1)	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	Homo sapiens (Human)	1270	FUNCTION: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.	MISCELLANEOUS: [Isoform 5]: Expressed at very low levels in most tissues. {ECO:0000305}.	regulation of macrophage chemotaxis [GO:0010758]	extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]	microtubule binding [GO:0008017]	extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; microtubule binding [GO:0008017]; regulation of macrophage chemotaxis [GO:0010758]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10697957, ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.
Q9ULD4	reviewed	BRPF3_HUMAN	Bromodomain and PHD finger-containing protein 3	BRPF3 KIAA1286	Homo sapiens (Human)	1205	FUNCTION: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}.		chromatin remodeling [GO:0006338]; positive regulation of DNA replication [GO:0045740]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; extracellular region [GO:0005576]; histone acetyltransferase complex [GO:0000123]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleus [GO:0005634]	metal ion binding [GO:0046872]	cytosol [GO:0005829]; extracellular region [GO:0005576]; histone acetyltransferase complex [GO:0000123]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; chromatin remodeling [GO:0006338]; positive regulation of DNA replication [GO:0045740]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26677226}.
Q9ULD5	reviewed	ZN777_HUMAN	Zinc finger protein 777	ZNF777 KIAA1285	Homo sapiens (Human)	831	FUNCTION: May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}.		negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; protein heterooligomerization [GO:0051291]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; protein heterooligomerization [GO:0051291]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25560148}.
Q9ULD6	reviewed	INTU_HUMAN	Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6)	INTU KIAA1284 PDZD6 PDZK6	Homo sapiens (Human)	942	FUNCTION: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). {ECO:0000250|UniProtKB:Q059U7, ECO:0000250|UniProtKB:Q2I0E5, ECO:0000305|PubMed:27158779}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell division [GO:0051301]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; hair follicle morphogenesis [GO:0031069]; intraciliary transport [GO:0042073]; keratinocyte differentiation [GO:0030216]; limb development [GO:0060173]; motile cilium assembly [GO:0044458]; negative regulation of cell division [GO:0051782]; negative regulation of keratinocyte proliferation [GO:0010839]; nervous system development [GO:0007399]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to organelle [GO:0033365]; regulation of cilium assembly [GO:1902017]; regulation of ossification [GO:0030278]; regulation of smoothened signaling pathway [GO:0008589]; roof of mouth development [GO:0060021]; smoothened signaling pathway [GO:0007224]; spinal cord dorsal/ventral patterning [GO:0021513]; tongue morphogenesis [GO:0043587]; vesicle-mediated transport [GO:0016192]	cell surface [GO:0009986]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]		cell surface [GO:0009986]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; cell division [GO:0051301]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; hair follicle morphogenesis [GO:0031069]; intraciliary transport [GO:0042073]; keratinocyte differentiation [GO:0030216]; limb development [GO:0060173]; motile cilium assembly [GO:0044458]; negative regulation of cell division [GO:0051782]; negative regulation of keratinocyte proliferation [GO:0010839]; nervous system development [GO:0007399]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to organelle [GO:0033365]; regulation of cilium assembly [GO:1902017]; regulation of ossification [GO:0030278]; regulation of smoothened signaling pathway [GO:0008589]; roof of mouth development [GO:0060021]; smoothened signaling pathway [GO:0007224]; spinal cord dorsal/ventral patterning [GO:0021513]; tongue morphogenesis [GO:0043587]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q059U7}. Cell surface {ECO:0000250|UniProtKB:Q2I0E5}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:26644512}. Note=Enriched at the apical surface in ciliated cells. {ECO:0000250}.
Q9ULD8	reviewed	KCNH3_HUMAN	Potassium voltage-gated channel subfamily H member 3 (Brain-specific eag-like channel 1) (BEC1) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Voltage-gated potassium channel subunit Kv12.2)	KCNH3 KIAA1282	Homo sapiens (Human)	1083	FUNCTION: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.		potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]	membrane [GO:0016020]; plasma membrane [GO:0005886]	voltage-gated potassium channel activity [GO:0005249]	membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9ULE0	reviewed	WWC3_HUMAN	Protein WWC3	WWC3 KIAA1280	Homo sapiens (Human)	1092			cell migration [GO:0016477]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; cell migration [GO:0016477]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330]	
Q9ULF5	reviewed	S39AA_HUMAN	Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10)	SLC39A10 KIAA1265 ZIP10	Homo sapiens (Human)	831	FUNCTION: Zinc-influx transporter (PubMed:30520657, PubMed:17359283, PubMed:27274087). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}.		epithelial to mesenchymal transition [GO:0001837]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of B cell apoptotic process [GO:0002903]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]; epithelial to mesenchymal transition [GO:0001837]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of B cell apoptotic process [GO:0002903]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27274087}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:30520657}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed at the apical membranes of proximal tubules in the kidney. {ECO:0000269|PubMed:30520657}.
Q9ULG1	reviewed	INO80_HUMAN	Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A)	INO80 INO80A INOC1 KIAA1259	Homo sapiens (Human)	1556	FUNCTION: ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}.	MISCELLANEOUS: Although the ATP-dependent helicase activity displayed by the INO80 complex requires INO80 ATPase activity, it is likely that the helicase function is carried out by the other components of the complex, RUVBL1 and RUVBL2, and not by INO80 itself. {ECO:0000269|PubMed:16230350}.	cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; spindle assembly [GO:0051225]; telomere maintenance [GO:0000723]; UV-damage excision repair [GO:0070914]	cytosol [GO:0005829]; Ino80 complex [GO:0031011]; microtubule [GO:0005874]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; histone binding [GO:0042393]	cytosol [GO:0005829]; Ino80 complex [GO:0031011]; microtubule [GO:0005874]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; histone binding [GO:0042393]; cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; spindle assembly [GO:0051225]; telomere maintenance [GO:0000723]; UV-damage excision repair [GO:0070914]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20237820}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00746, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20971067}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20237820}. Chromosome {ECO:0000269|PubMed:20237820}. Note=Localizes to the cytoplasm in quiescent cell (PubMed:20237820). Associates with spindle microtubules during mitosis (PubMed:20237820). Colocalizes with PCNA at replication forks during S-phase (PubMed:20237820). Recruited to DNA damage sites in a ACTR8-dependent manner (PubMed:20971067). {ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20971067}.
Q9ULG6	reviewed	CCPG1_HUMAN	Cell cycle progression protein 1 (Cell cycle progression restoration protein 8)	CCPG1 CCP8 CPR8 KIAA1254	Homo sapiens (Human)	757	FUNCTION: Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation. {ECO:0000250, ECO:0000269|PubMed:9383053}.		cell cycle [GO:0007049]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]	membrane [GO:0016020]		membrane [GO:0016020]; cell cycle [GO:0007049]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cytoplasmic granule membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9ULH0	reviewed	KDIS_HUMAN	Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)	KIDINS220 ARMS KIAA1250	Homo sapiens (Human)	1771	FUNCTION: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.		cellular response to nerve growth factor stimulus [GO:1990090]; dendrite morphogenesis [GO:0048813]; in utero embryonic development [GO:0001701]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron projection development [GO:0010976]	cytosol [GO:0005829]; late endosome [GO:0005770]; membrane [GO:0016020]; protein-containing complex [GO:0032991]	PDZ domain binding [GO:0030165]; protein kinase regulator activity [GO:0019887]	cytosol [GO:0005829]; late endosome [GO:0005770]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; PDZ domain binding [GO:0030165]; protein kinase regulator activity [GO:0019887]; cellular response to nerve growth factor stimulus [GO:1990090]; dendrite morphogenesis [GO:0048813]; in utero embryonic development [GO:0001701]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron projection development [GO:0010976]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Late endosome {ECO:0000250}. Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation.
Q9ULH1	reviewed	ASAP1_HUMAN	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)	ASAP1 DDEF1 KIAA1249 PAG2	Homo sapiens (Human)	1129	FUNCTION: Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}.		cilium assembly [GO:0060271]; negative regulation of dendritic spine development [GO:0061000]; positive regulation of membrane tubulation [GO:1903527]; protein localization to cilium [GO:0061512]; regulation of postsynapse organization [GO:0099175]	cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; podosome [GO:0002102]; trans-Golgi network membrane [GO:0032588]	cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]	cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; podosome [GO:0002102]; trans-Golgi network membrane [GO:0032588]; cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; cilium assembly [GO:0060271]; negative regulation of dendritic spine development [GO:0061000]; positive regulation of membrane tubulation [GO:1903527]; protein localization to cilium [GO:0061512]; regulation of postsynapse organization [GO:0099175]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Golgi apparatus {ECO:0000269|PubMed:25673879}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:25673879}. Note=Predominantly cytoplasmic. Partially membrane-associated. Localized to the Golgi, TGN and rhodopsin transport carriers (RTC) when interacting with RHO in photoreceptors (PubMed:25673879). Localized to RTC when interacting with RAB11A and RAB11FIP3 in photoreceptors (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:25673879}.
Q9ULH4	reviewed	LRFN2_HUMAN	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 (Synaptic adhesion-like molecule 1)	LRFN2 KIAA1246 SALM1	Homo sapiens (Human)	789	FUNCTION: Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity). {ECO:0000250}.		modulation of chemical synaptic transmission [GO:0050804]; regulation of postsynapse organization [GO:0099175]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]		cell surface [GO:0009986]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; modulation of chemical synaptic transmission [GO:0050804]; regulation of postsynapse organization [GO:0099175]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Synapse. Postsynaptic cell membrane {ECO:0000250}.
Q9ULH7	reviewed	MRTFB_HUMAN	Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2)	MRTFB KIAA1243 MKL2	Homo sapiens (Human)	1088	FUNCTION: Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}.		muscle organ development [GO:0007517]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of striated muscle tissue development [GO:0045844]; positive regulation of transcription by RNA polymerase II [GO:0045944]; smooth muscle cell differentiation [GO:0051145]	nucleus [GO:0005634]	cadherin binding [GO:0045296]; transcription coactivator activity [GO:0003713]	nucleus [GO:0005634]; cadherin binding [GO:0045296]; transcription coactivator activity [GO:0003713]; muscle organ development [GO:0007517]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of striated muscle tissue development [GO:0045844]; positive regulation of transcription by RNA polymerase II [GO:0045944]; smooth muscle cell differentiation [GO:0051145]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9ULI0	reviewed	ATD2B_HUMAN	ATPase family AAA domain-containing protein 2B	ATAD2B KIAA1240	Homo sapiens (Human)	1458			positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24561620, ECO:0000269|PubMed:25593309}. Note=Partially localizes to replication sites.
Q9ULI2	reviewed	RIMKB_HUMAN	Beta-citrylglutamate synthase B (EC 6.3.1.17) (N-acetyl-aspartylglutamate synthetase B) (NAAG synthetase B) (NAAGS) (EC 6.3.2.41) (Ribosomal protein S6 modification-like protein B)	RIMKLB FAM80B KIAA1238	Homo sapiens (Human)	386	FUNCTION: Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate. {ECO:0000250|UniProtKB:Q80WS1}.	MISCELLANEOUS: N-acetyl-L-aspartyl-L-glutamate (NAAG) is the most abundant dipeptide present in vertebrate central nervous system (CNS). Beta-citryl-L-glutamate, a structural analog of NAAG, is present in testis and immature brain. {ECO:0000250|UniProtKB:Q80WS1}.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	glutamine family amino acid metabolic process [GO:0009064]; protein modification process [GO:0036211]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; citrate-L-glutamate ligase activity [GO:0072591]; metal ion binding [GO:0046872]; N-acetyl-L-aspartate-L-glutamate ligase activity [GO:0072590]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; citrate-L-glutamate ligase activity [GO:0072591]; metal ion binding [GO:0046872]; N-acetyl-L-aspartate-L-glutamate ligase activity [GO:0072590]; glutamine family amino acid metabolic process [GO:0009064]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9ULI3	reviewed	HEG1_HUMAN	Protein HEG homolog 1	HEG1 KIAA1237	Homo sapiens (Human)	1381	FUNCTION: Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}.		cardiac atrium morphogenesis [GO:0003209]; cardiac muscle tissue growth [GO:0055017]; cell-cell junction organization [GO:0045216]; endothelial cell morphogenesis [GO:0001886]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; lymph circulation [GO:0003017]; lymph vessel development [GO:0001945]; multicellular organism growth [GO:0035264]; negative regulation of membrane permeability [GO:1905709]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000299]; pericardium development [GO:0060039]; positive regulation of fibroblast growth factor production [GO:0090271]; post-embryonic development [GO:0009791]; protein localization to cell junction [GO:1902414]; regulation of body fluid levels [GO:0050878]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]; ventricular septum development [GO:0003281]; ventricular trabecula myocardium morphogenesis [GO:0003222]	cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]	calcium ion binding [GO:0005509]	cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; cardiac atrium morphogenesis [GO:0003209]; cardiac muscle tissue growth [GO:0055017]; cell-cell junction organization [GO:0045216]; endothelial cell morphogenesis [GO:0001886]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; lymph circulation [GO:0003017]; lymph vessel development [GO:0001945]; multicellular organism growth [GO:0035264]; negative regulation of membrane permeability [GO:1905709]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000299]; pericardium development [GO:0060039]; positive regulation of fibroblast growth factor production [GO:0090271]; post-embryonic development [GO:0009791]; protein localization to cell junction [GO:1902414]; regulation of body fluid levels [GO:0050878]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]; ventricular septum development [GO:0003281]; ventricular trabecula myocardium morphogenesis [GO:0003222]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q9ULI4	reviewed	KI26A_HUMAN	Kinesin-like protein KIF26A	KIF26A KIAA1236	Homo sapiens (Human)	1882	FUNCTION: Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}.		cerebral cortex development [GO:0021987]; enteric nervous system development [GO:0048484]; negative regulation of signal transduction [GO:0009968]; regulation of cell growth by extracellular stimulus [GO:0001560]; regulation of neuron migration [GO:2001222]; regulation of neuron projection development [GO:0010975]	cytosol [GO:0005829]; microtubule [GO:0005874]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]	cytosol [GO:0005829]; microtubule [GO:0005874]; ATP binding [GO:0005524]; microtubule binding [GO:0008017]; cerebral cortex development [GO:0021987]; enteric nervous system development [GO:0048484]; negative regulation of signal transduction [GO:0009968]; regulation of cell growth by extracellular stimulus [GO:0001560]; regulation of neuron migration [GO:2001222]; regulation of neuron projection development [GO:0010975]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
Q9ULJ1	reviewed	ODF2L_HUMAN	Protein BCAP (Basal body centriole-associated protein) (Outer dense fiber protein 2-like) (ODF2-like protein)	ODF2L BCAP KIAA1229	Homo sapiens (Human)	636	FUNCTION: Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis. {ECO:0000269|PubMed:28775150}.		cell projection organization [GO:0030030]; negative regulation of cilium assembly [GO:1902018]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]		centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cell projection organization [GO:0030030]; negative regulation of cilium assembly [GO:1902018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17485331}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:17485331}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:28775150}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17485331}. Note=Localizes to centrioles in proliferative cells and basal bodies in ciliated cells (PubMed:17485331). Disappears during ciliogenesis but reappears, albeit at a lower levels once ciliogenesis has completed (PubMed:28775150). {ECO:0000269|PubMed:17485331, ECO:0000269|PubMed:28775150}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:28775150}. Note=Not present in the centrioles in cycling cells. Disappears during ciliogenesis. {ECO:0000269|PubMed:28775150}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:28775150}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28775150}. Note=Disappears during ciliogenesis but reappears, albeit at a lower levels once ciliogenesis has completed. {ECO:0000269|PubMed:28775150}.
Q9ULJ3	reviewed	ZBT21_HUMAN	Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295)	ZBTB21 KIAA1227 ZNF295	Homo sapiens (Human)	1066	FUNCTION: Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; POZ domain binding [GO:0031208]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; POZ domain binding [GO:0031208]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15629158}. Note=Colocalizes with ZBTB14 in nucleus in HEK293 cells.
Q9ULJ6	reviewed	ZMIZ1_HUMAN	Zinc finger MIZ domain-containing protein 1 (PIAS-like protein Zimp10) (Retinoic acid-induced protein 17)	ZMIZ1 KIAA1224 RAI17 ZIMP10	Homo sapiens (Human)	1067	FUNCTION: Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (PubMed:16777850). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity). Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (PubMed:30639322). {ECO:0000250|UniProtKB:Q6P1E1, ECO:0000269|PubMed:14609956, ECO:0000269|PubMed:16777850, ECO:0000269|PubMed:26522984, ECO:0000269|PubMed:30639322}.		androgen receptor signaling pathway [GO:0030521]; artery morphogenesis [GO:0048844]; cellular senescence [GO:0090398]; developmental growth [GO:0048589]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]; pyramidal neuron migration to cerebral cortex [GO:0021852]; regulation of transcription by RNA polymerase II [GO:0006357]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570]; vitellogenesis [GO:0007296]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear receptor coactivator activity [GO:0030374]; SMAD binding [GO:0046332]; SUMO ligase activity [GO:0061665]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear receptor coactivator activity [GO:0030374]; SMAD binding [GO:0046332]; SUMO ligase activity [GO:0061665]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]; androgen receptor signaling pathway [GO:0030521]; artery morphogenesis [GO:0048844]; cellular senescence [GO:0090398]; developmental growth [GO:0048589]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]; pyramidal neuron migration to cerebral cortex [GO:0021852]; regulation of transcription by RNA polymerase II [GO:0006357]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570]; vitellogenesis [GO:0007296]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:14609956, ECO:0000269|PubMed:16777850}. Cytoplasm {ECO:0000269|PubMed:14609956}. Nucleus {ECO:0000269|PubMed:30639322}. Note=Enriched at replication foci throughout S phase. {ECO:0000269|PubMed:14609956}.
Q9ULJ8	reviewed	NEB1_HUMAN	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A)	PPP1R9A KIAA1222	Homo sapiens (Human)	1098	FUNCTION: Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; modulation of chemical synaptic transmission [GO:0050804]; neuron projection development [GO:0031175]	actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; filopodium [GO:0030175]; postsynaptic density [GO:0014069]	actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; filopodium [GO:0030175]; postsynaptic density [GO:0014069]; actin filament binding [GO:0051015]; actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; modulation of chemical synaptic transmission [GO:0050804]; neuron projection development [GO:0031175]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Synapse, synaptosome {ECO:0000250}.
Q9ULK0	reviewed	GRID1_HUMAN	Glutamate receptor ionotropic, delta-1 (GluD1) (GluR delta-1 subunit)	GRID1 KIAA1220	Homo sapiens (Human)	1009	FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.		modulation of chemical synaptic transmission [GO:0050804]; regulation of postsynapse organization [GO:0099175]; social behavior [GO:0035176]; synaptic transmission, glutamatergic [GO:0035249]	extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; ionotropic glutamate receptor activity [GO:0004970]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; ionotropic glutamate receptor activity [GO:0004970]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; modulation of chemical synaptic transmission [GO:0050804]; regulation of postsynapse organization [GO:0099175]; social behavior [GO:0035176]; synaptic transmission, glutamatergic [GO:0035249]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9ULK4	reviewed	MED23_HUMAN	Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130)	MED23 ARC130 CRSP3 DRIP130 KIAA1216 SUR2	Homo sapiens (Human)	1368	FUNCTION: Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269|PubMed:10353252, ECO:0000269|PubMed:14759369, ECO:0000269|PubMed:16595664}.		positive regulation of gene expression [GO:0010628]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	transcription coactivator activity [GO:0003713]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription coactivator activity [GO:0003713]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9ULK5	reviewed	VANG2_HUMAN	Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2)	VANGL2 KIAA1215 STB1	Homo sapiens (Human)	521	FUNCTION: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q91ZD4}.		apical protein localization [GO:0045176]; cell migration involved in kidney development [GO:0035787]; establishment of planar polarity [GO:0001736]; heart looping [GO:0001947]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]		apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; apical protein localization [GO:0045176]; cell migration involved in kidney development [GO:0035787]; establishment of planar polarity [GO:0001736]; heart looping [GO:0001947]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9ULL4	reviewed	PLXB3_HUMAN	Plexin-B3	PLXNB3 KIAA1206 PLXN6	Homo sapiens (Human)	1909	FUNCTION: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.		cell chemotaxis [GO:0060326]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell migration [GO:0030336]; negative regulation of GTPase activity [GO:0034260]; negative regulation of lamellipodium assembly [GO:0010593]; positive chemotaxis [GO:0050918]; positive regulation of axonogenesis [GO:0050772]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of neuron projection development [GO:0010976]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	cell-cell adhesion mediator activity [GO:0098632]; protein domain specific binding [GO:0019904]; Rho GDP-dissociation inhibitor binding [GO:0051022]; semaphorin receptor activity [GO:0017154]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]; cell-cell adhesion mediator activity [GO:0098632]; protein domain specific binding [GO:0019904]; Rho GDP-dissociation inhibitor binding [GO:0051022]; semaphorin receptor activity [GO:0017154]; cell chemotaxis [GO:0060326]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell migration [GO:0030336]; negative regulation of GTPase activity [GO:0034260]; negative regulation of lamellipodium assembly [GO:0010593]; positive chemotaxis [GO:0050918]; positive regulation of axonogenesis [GO:0050772]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of neuron projection development [GO:0010976]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:16122393}; Single-pass type I membrane protein {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:16122393}. Note=Colocalizes with RIT2/RIN at the plasma membrane.
Q9ULL8	reviewed	SHRM4_HUMAN	Protein Shroom4 (Second homolog of apical protein)	SHROOM4 KIAA1202 SHAP	Homo sapiens (Human)	1493	FUNCTION: Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}.		actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; brain development [GO:0007420]; cognition [GO:0050890]	actin filament [GO:0005884]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; stress fiber [GO:0001725]	actin filament binding [GO:0051015]; myosin II binding [GO:0045159]	actin filament [GO:0005884]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; stress fiber [GO:0001725]; actin filament binding [GO:0051015]; myosin II binding [GO:0045159]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; brain development [GO:0007420]; cognition [GO:0050890]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16249884, ECO:0000269|PubMed:16684770}. Note=Shows partial colocalization with the cytoplasmic pool of F-actin.
Q9ULM2	reviewed	ZN490_HUMAN	Zinc finger protein 490	ZNF490 KIAA1198	Homo sapiens (Human)	529	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9ULM3	reviewed	YETS2_HUMAN	YEATS domain-containing protein 2	YEATS2 KIAA1197	Homo sapiens (Human)	1422	FUNCTION: Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}.		chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]	histone binding [GO:0042393]; histone reader activity [GO:0140566]; modification-dependent protein binding [GO:0140030]; TBP-class protein binding [GO:0017025]; transcription corepressor activity [GO:0003714]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; modification-dependent protein binding [GO:0140030]; TBP-class protein binding [GO:0017025]; transcription corepressor activity [GO:0003714]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:18838386, ECO:0000305|PubMed:19103755}.
Q9ULM6	reviewed	CNOT6_HUMAN	CCR4-NOT transcription complex subunit 6 (EC 3.1.13.4) (CCR4 carbon catabolite repression 4-like) (Carbon catabolite repressor protein 4 homolog) (Cytoplasmic deadenylase)	CNOT6 CCR4 CCR4a KIAA1194	Homo sapiens (Human)	557	FUNCTION: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:11889047, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:21233283}.		exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; nuclear receptor coactivator activity [GO:0030374]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723]; RNA exonuclease activity [GO:0004532]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; nuclear receptor coactivator activity [GO:0030374]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723]; RNA exonuclease activity [GO:0004532]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96LI5}. Nucleus {ECO:0000250|UniProtKB:Q96LI5}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:Q96LI5}.
Q9ULP0	reviewed	NDRG4_HUMAN	Protein NDRG4 (Brain development-related molecule 1) (N-myc downstream-regulated gene 4 protein) (Vascular smooth muscle cell-associated protein 8) (SMAP-8)	NDRG4 BDM1 KIAA1180	Homo sapiens (Human)	352	FUNCTION: Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. {ECO:0000250, ECO:0000269|PubMed:12755708}.		cardiac muscle cell proliferation [GO:0060038]; cell differentiation [GO:0030154]; cell migration involved in heart development [GO:0060973]; embryonic heart tube development [GO:0035050]; heart looping [GO:0001947]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of neuron projection development [GO:0010976]; regulation of endocytic recycling [GO:2001135]; signal transduction [GO:0007165]; vesicle docking [GO:0048278]; visual learning [GO:0008542]	basolateral plasma membrane [GO:0016323]; cell projection membrane [GO:0031253]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]		basolateral plasma membrane [GO:0016323]; cell projection membrane [GO:0031253]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; cardiac muscle cell proliferation [GO:0060038]; cell differentiation [GO:0030154]; cell migration involved in heart development [GO:0060973]; embryonic heart tube development [GO:0035050]; heart looping [GO:0001947]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of neuron projection development [GO:0010976]; regulation of endocytic recycling [GO:2001135]; signal transduction [GO:0007165]; vesicle docking [GO:0048278]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12755708, ECO:0000269|PubMed:19592488}.
Q9ULP9	reviewed	TBC24_HUMAN	TBC1 domain family member 24	TBC1D24 KIAA1171	Homo sapiens (Human)	559	FUNCTION: May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515, PubMed:20797691). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515). Involved in the regulation of synaptic vesicle trafficking (PubMed:31257402). {ECO:0000269|PubMed:20727515, ECO:0000269|PubMed:20797691, ECO:0000269|PubMed:31257402}.		axon development [GO:0061564]; cellular response to oxidative stress [GO:0034599]; dendrite development [GO:0016358]; negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuron projection development [GO:0031175]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron migration [GO:2001224]; synaptic vesicle endocytosis [GO:0048488]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; terminal bouton [GO:0043195]	GTPase activator activity [GO:0005096]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; terminal bouton [GO:0043195]; GTPase activator activity [GO:0005096]; axon development [GO:0061564]; cellular response to oxidative stress [GO:0034599]; dendrite development [GO:0016358]; negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuron projection development [GO:0031175]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron migration [GO:2001224]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20727515}; Peripheral membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:20727515}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9VIH7}. Presynapse {ECO:0000269|PubMed:31257402}. Note=Mainly cytoplasmatic with partial expression at the plasma membrane (PubMed:20727515). Associates with certain types of membrane phosphoinositides, preferentially those phosphorylated at the D5 position of the inositol ring such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). {ECO:0000250|UniProtKB:Q9VIH7, ECO:0000269|PubMed:20727515}.
Q9ULQ0	reviewed	STRP2_HUMAN	Striatin-interacting protein 2 (Protein FAM40B)	STRIP2 FAM40B KIAA1170	Homo sapiens (Human)	834	FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:21834987}.		cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]	cytoplasm [GO:0005737]; cytosol [GO:0005829]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21834987}. Note=Enriched in lamellipodia.
Q9ULQ1	reviewed	TPC1_HUMAN	Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1)	TPCN1 KIAA1169 TPC1	Homo sapiens (Human)	816	FUNCTION: Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:19620632, PubMed:23063126, PubMed:24776928, PubMed:23394946). Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (PubMed:23394946) (Probable). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (PubMed:23394946) (Probable). {ECO:0000269|PubMed:19620632, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:23394946, ECO:0000269|PubMed:24776928, ECO:0000305|PubMed:32679067}.; FUNCTION: (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. {ECO:0000269|PubMed:25722412}.		endocytosis involved in viral entry into host cell [GO:0075509]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of autophagy [GO:0010508]; regulation of monoatomic ion transmembrane transport [GO:0034765]	early endosome membrane [GO:0031901]; endolysosome [GO:0036019]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; recycling endosome membrane [GO:0055038]	identical protein binding [GO:0042802]; intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity [GO:0097682]; ligand-gated sodium channel activity [GO:0015280]; NAADP-sensitive calcium-release channel activity [GO:0072345]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated sodium channel activity [GO:0005248]	early endosome membrane [GO:0031901]; endolysosome [GO:0036019]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; recycling endosome membrane [GO:0055038]; identical protein binding [GO:0042802]; intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity [GO:0097682]; ligand-gated sodium channel activity [GO:0015280]; NAADP-sensitive calcium-release channel activity [GO:0072345]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated sodium channel activity [GO:0005248]; endocytosis involved in viral entry into host cell [GO:0075509]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of autophagy [GO:0010508]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:19620632, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:25722412}; Multi-pass membrane protein {ECO:0000269|PubMed:19620632}. Endosome membrane {ECO:0000269|PubMed:19620632, ECO:0000269|PubMed:20880839, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:25722412}; Multi-pass membrane protein {ECO:0000269|PubMed:19620632}. Early endosome membrane {ECO:0000250|UniProtKB:Q9EQJ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9EQJ0}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9EQJ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9EQJ0}.
Q9ULR0	reviewed	ISY1_HUMAN	Pre-mRNA-splicing factor ISY1 homolog	ISY1 KIAA1160	Homo sapiens (Human)	285	FUNCTION: Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome. {ECO:0000250|UniProtKB:Q69ZQ2, ECO:0000269|PubMed:29301961, ECO:0000305|PubMed:11991638, ECO:0000305|PubMed:25599396}.	MISCELLANEOUS: [Isoform 2]: Based on a readthrough transcript which may produce a ISY1-RAB43 fusion protein. {ECO:0000305}.	generation of catalytic spliceosome for second transesterification step [GO:0000350]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006]; RNA binding [GO:0003723]; generation of catalytic spliceosome for second transesterification step [GO:0000350]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:29301961}.
Q9ULR3	reviewed	PPM1H_HUMAN	Protein phosphatase 1H (EC 3.1.3.16)	PPM1H ARHCL1 KIAA1157 URCC2	Homo sapiens (Human)	514	FUNCTION: Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. {ECO:0000269|PubMed:22586611}.	MISCELLANEOUS: May act as a suppressor of trastuzumab resistance. {ECO:0000303|PubMed:22586611}.		cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	[pyruvate dehydrogenase (lipoamide)] phosphatase activity [GO:0004741]; identical protein binding [GO:0042802]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; [pyruvate dehydrogenase (lipoamide)] phosphatase activity [GO:0004741]; identical protein binding [GO:0042802]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22586611}. Cytoplasm {ECO:0000269|PubMed:22586611}.
Q9ULT0	reviewed	TTC7A_HUMAN	Tetratricopeptide repeat protein 7A (TPR repeat protein 7A)	TTC7A KIAA1140 TTC7	Homo sapiens (Human)	858	FUNCTION: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25546680}. Cell membrane {ECO:0000250|UniProtKB:Q86TV6}. Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with EFR3 (EFR3A or EFR3B). {ECO:0000250|UniProtKB:Q86TV6}.
Q9ULT6	reviewed	ZNRF3_HUMAN	E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3)	ZNRF3 KIAA1133 RNF203	Homo sapiens (Human)	936	FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity). {ECO:0000250|UniProtKB:Q08D68, ECO:0000269|PubMed:22575959}.		limb development [GO:0060173]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein ubiquitination [GO:0016567]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; stem cell proliferation [GO:0072089]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt receptor catabolic process [GO:0038018]; Wnt signaling pathway [GO:0016055]	plasma membrane [GO:0005886]	frizzled binding [GO:0005109]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	plasma membrane [GO:0005886]; frizzled binding [GO:0005109]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; limb development [GO:0060173]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein ubiquitination [GO:0016567]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; stem cell proliferation [GO:0072089]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt receptor catabolic process [GO:0038018]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22575959}; Single-pass type I membrane protein {ECO:0000255}.
Q9ULT8	reviewed	HECD1_HUMAN	E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)	HECTD1 KIAA1131	Homo sapiens (Human)	2610	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}.		anatomical structure development [GO:0048856]; aorta development [GO:0035904]; heart valve development [GO:0003170]; natural killer cell differentiation [GO:0001779]; negative regulation of protein localization to plasma membrane [GO:1903077]; neural tube closure [GO:0001843]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein localization to plasma membrane [GO:0072659]; protein ubiquitination [GO:0016567]; spongiotrophoblast differentiation [GO:0060708]; trophoblast giant cell differentiation [GO:0060707]; ventricular septum development [GO:0003281]	nuclear speck [GO:0016607]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	nuclear speck [GO:0016607]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; anatomical structure development [GO:0048856]; aorta development [GO:0035904]; heart valve development [GO:0003170]; natural killer cell differentiation [GO:0001779]; negative regulation of protein localization to plasma membrane [GO:1903077]; neural tube closure [GO:0001843]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein localization to plasma membrane [GO:0072659]; protein ubiquitination [GO:0016567]; spongiotrophoblast differentiation [GO:0060708]; trophoblast giant cell differentiation [GO:0060707]; ventricular septum development [GO:0003281]	
Q9ULU4	reviewed	ZMYD8_HUMAN	MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8)	ZMYND8 KIAA1125 PRKCBP1 RACK7	Homo sapiens (Human)	1186	FUNCTION: Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:31965980, PubMed:36064715, PubMed:27477906). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:30134174, PubMed:25593309, PubMed:27732854). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:30134174, PubMed:26655721). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:36064715, PubMed:35916866, PubMed:30134174). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}.		chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; modulation of excitatory postsynaptic potential [GO:0098815]; negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein localization to chromatin [GO:0071168]; regulation of postsynaptic density protein 95 clustering [GO:1902897]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	DNA-binding transcription factor binding [GO:0140297]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; protein domain specific binding [GO:0019904]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; DNA-binding transcription factor binding [GO:0140297]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; protein domain specific binding [GO:0019904]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; modulation of excitatory postsynaptic potential [GO:0098815]; negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein localization to chromatin [GO:0071168]; regulation of postsynaptic density protein 95 clustering [GO:1902897]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28966017}. Chromosome {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:36064715}. Cytoplasm {ECO:0000269|PubMed:28966017}. Note=Sequestered in the cytoplasm through the interaction with DBN1 (PubMed:28966017). Localizes to sites of DNA damage in a KAT5-dependent and DNA poly (ADP-ribose)-dependent manner (PubMed:25593309, PubMed:27732854). On chromatin, localizes to demethylated regions, active promoters, and transcription start sites (PubMed:36064715, PubMed:27732854). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28966017, ECO:0000269|PubMed:36064715}.
Q9ULU8	reviewed	CAPS1_HUMAN	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1)	CADPS CAPS CAPS1 KIAA1121	Homo sapiens (Human)	1353	FUNCTION: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}.		dense core granule exocytosis [GO:1990504]; exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; neuronal dense core vesicle membrane [GO:0099012]; presynapse [GO:0098793]	lipid binding [GO:0008289]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; neuronal dense core vesicle membrane [GO:0099012]; presynapse [GO:0098793]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; dense core granule exocytosis [GO:1990504]; exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079]	SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q62717}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250|UniProtKB:Q62717}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62717}. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to dense core vesicles but not to synaptic vesicles. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2. {ECO:0000250|UniProtKB:Q62717}.
Q9ULV0	reviewed	MYO5B_HUMAN	Unconventional myosin-Vb	MYO5B KIAA1119	Homo sapiens (Human)	1848	FUNCTION: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes (PubMed:34816459). {ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:34816459}.		actin filament organization [GO:0007015]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; renal water homeostasis [GO:0003091]; vesicle transport along actin filament [GO:0030050]; vesicle-mediated transport [GO:0016192]	actin cytoskeleton [GO:0015629]; apical cortex [GO:0045179]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; myosin complex [GO:0016459]; protein-containing complex [GO:0032991]; vesicle [GO:0031982]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; apical cortex [GO:0045179]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; myosin complex [GO:0016459]; protein-containing complex [GO:0032991]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; small GTPase binding [GO:0031267]; actin filament organization [GO:0007015]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; renal water homeostasis [GO:0003091]; vesicle transport along actin filament [GO:0030050]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P70569}.
Q9ULV1	reviewed	FZD4_HUMAN	Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344)	FZD4	Homo sapiens (Human)	537	FUNCTION: Receptor for Wnt proteins (PubMed:30135577). Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (PubMed:30135577). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. {ECO:0000250|UniProtKB:Q61088, ECO:0000269|PubMed:30135577}.		angiogenesis [GO:0001525]; canonical Wnt signaling pathway [GO:0060070]; cell population proliferation [GO:0008283]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; cerebellum vasculature morphogenesis [GO:0061301]; endothelial cell differentiation [GO:0045446]; establishment of blood-brain barrier [GO:0060856]; extracellular matrix-cell signaling [GO:0035426]; locomotion involved in locomotory behavior [GO:0031987]; negative regulation of cell-substrate adhesion [GO:0010812]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; Norrin signaling pathway [GO:0110135]; positive regulation of cell migration [GO:0030335]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection arborization [GO:0150012]; progesterone secretion [GO:0042701]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; response to hypoxia [GO:0001666]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal blood vessel morphogenesis [GO:0061304]; sensory perception of sound [GO:0007605]; substrate adhesion-dependent cell spreading [GO:0034446]; vasculogenesis [GO:0001570]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]	cell surface [GO:0009986]; cell-cell junction [GO:0005911]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]	amyloid-beta binding [GO:0001540]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; cell-cell junction [GO:0005911]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; amyloid-beta binding [GO:0001540]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; angiogenesis [GO:0001525]; canonical Wnt signaling pathway [GO:0060070]; cell population proliferation [GO:0008283]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; cerebellum vasculature morphogenesis [GO:0061301]; endothelial cell differentiation [GO:0045446]; establishment of blood-brain barrier [GO:0060856]; extracellular matrix-cell signaling [GO:0035426]; locomotion involved in locomotory behavior [GO:0031987]; negative regulation of cell-substrate adhesion [GO:0010812]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; Norrin signaling pathway [GO:0110135]; positive regulation of cell migration [GO:0030335]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection arborization [GO:0150012]; progesterone secretion [GO:0042701]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; response to hypoxia [GO:0001666]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal blood vessel morphogenesis [GO:0061304]; sensory perception of sound [GO:0007605]; substrate adhesion-dependent cell spreading [GO:0034446]; vasculogenesis [GO:0001570]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30135577}; Multi-pass membrane protein {ECO:0000255}.
Q9ULV3	reviewed	CIZ1_HUMAN	Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356)	CIZ1 LSFR1 NP94 ZNF356	Homo sapiens (Human)	898	FUNCTION: May regulate the subcellular localization of CIP/WAF1.		maintenance of protein location in nucleus [GO:0051457]; positive regulation of DNA-templated DNA replication initiation [GO:0032298]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cyclin binding [GO:0030332]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cyclin binding [GO:0030332]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; maintenance of protein location in nucleus [GO:0051457]; positive regulation of DNA-templated DNA replication initiation [GO:0032298]	SUBCELLULAR LOCATION: Nucleus.
Q9ULV4	reviewed	COR1C_HUMAN	Coronin-1C (Coronin-3) (hCRNN4)	CORO1C CRN2 CRNN4	Homo sapiens (Human)	474	FUNCTION: Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}.	MISCELLANEOUS: [Isoform 3]: Exclusively expressed in well-differentiated myoblasts as well as in mature skeletal muscle. {ECO:0000305}.	actin filament organization [GO:0007015]; activation of GTPase activity [GO:0090630]; corpus callosum development [GO:0022038]; endosomal transport [GO:0016197]; endosome fission [GO:0140285]; endosome membrane tubulation [GO:0097750]; establishment of protein localization [GO:0045184]; membrane fission [GO:0090148]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neural crest cell migration [GO:0001755]; phagocytosis [GO:0006909]; positive regulation of lamellipodium morphogenesis [GO:2000394]; regulation of epithelial cell migration [GO:0010632]; regulation of fibroblast migration [GO:0010762]; regulation of focal adhesion assembly [GO:0051893]; regulation of protein phosphorylation [GO:0001932]; regulation of ruffle assembly [GO:1900027]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; signal transduction [GO:0007165]; ventricular system development [GO:0021591]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; endosome membrane [GO:0010008]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]; sarcomere [GO:0030017]; synapse [GO:0045202]	actin filament binding [GO:0051015]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; endosome membrane [GO:0010008]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]; sarcomere [GO:0030017]; synapse [GO:0045202]; actin filament binding [GO:0051015]; small GTPase binding [GO:0031267]; actin filament organization [GO:0007015]; activation of GTPase activity [GO:0090630]; corpus callosum development [GO:0022038]; endosomal transport [GO:0016197]; endosome fission [GO:0140285]; endosome membrane tubulation [GO:0097750]; establishment of protein localization [GO:0045184]; membrane fission [GO:0090148]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neural crest cell migration [GO:0001755]; phagocytosis [GO:0006909]; positive regulation of lamellipodium morphogenesis [GO:2000394]; regulation of epithelial cell migration [GO:0010632]; regulation of fibroblast migration [GO:0010762]; regulation of focal adhesion assembly [GO:0051893]; regulation of protein phosphorylation [GO:0001932]; regulation of ruffle assembly [GO:1900027]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; signal transduction [GO:0007165]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12377779, ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950}; Peripheral membrane protein {ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950}; Cytoplasmic side {ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950}. Cell projection, lamellipodium {ECO:0000269|PubMed:12377779, ECO:0000269|PubMed:19651142}. Cell projection, ruffle membrane {ECO:0000269|PubMed:25074804}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10828594, ECO:0000269|PubMed:12377779, ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:25074804}. Cytoplasm, cell cortex {ECO:0000269|PubMed:10828594, ECO:0000269|PubMed:19651142}. Endosome membrane {ECO:0000269|PubMed:30220460}. Note=All isoforms colocalize with the actin cytoskeleton in the cytosol, and especially in the cell cortex (PubMed:10828594, PubMed:19651142, PubMed:25074804). Colocalizes with F-actin at the leading edge of lamellipodia. Partially colocalizes with microtubules and vimentin intermediate filaments (PubMed:10828594, PubMed:19651142, PubMed:25074804). Localizes to endosome membrane tubules/buds (PubMed:30220460). {ECO:0000269|PubMed:10828594, ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:30220460}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane, sarcolemma {ECO:0000269|PubMed:19651142}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:19651142}. Synapse {ECO:0000269|PubMed:19651142}. Cell membrane {ECO:0000269|PubMed:19651142}; Peripheral membrane protein {ECO:0000269|PubMed:19651142}; Cytoplasmic side {ECO:0000269|PubMed:19651142}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19651142}. Cytoplasm, cell cortex {ECO:0000269|PubMed:19651142}. Note=Colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates. Colocalizes with the actin cytoskeleton in the cytosol, and especially in the cell cortex. {ECO:0000269|PubMed:19651142}.
Q9ULV5	reviewed	HSF4_HUMAN	Heat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4)	HSF4	Homo sapiens (Human)	492	FUNCTION: Heat-shock transcription factor that specifically binds heat shock promoter elements (HSE) (PubMed:22587838, PubMed:23507146). Required for denucleation and organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (By similarity). In this process, may regulate denucleation of lens fiber cells in part by activating DNASE2B transcription (By similarity). May be involved in DNA repair through the transcriptional regulation of RAD51 (PubMed:22587838). May up-regulate p53/TP53 protein in eye lens fiber cells, possibly through protein stabilization (PubMed:28981088). In the eye lens, controls the expression of alpha-crystallin B chain/CRYAB and consequently may be involved in the regulation of lysosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q5CZP2, ECO:0000250|UniProtKB:Q9R0L1, ECO:0000269|PubMed:22587838, ECO:0000269|PubMed:23507146, ECO:0000269|PubMed:28981088}.; FUNCTION: [Isoform HSF4A]: Transcriptional repressor. {ECO:0000269|PubMed:10488131}.; FUNCTION: [Isoform HSF4B]: Transcriptional activator. {ECO:0000269|PubMed:10488131, ECO:0000269|PubMed:16371476}.		lens fiber cell differentiation [GO:0070306]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; lens fiber cell differentiation [GO:0070306]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10488131}.
Q9ULV8	reviewed	CBLC_HUMAN	E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C)	CBLC CBL3 RNF57	Homo sapiens (Human)	474	FUNCTION: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. {ECO:0000269|PubMed:10362357, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:18753381, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:23145173}.	MISCELLANEOUS: This protein has one functional calcium-binding site.	cell surface receptor signaling pathway [GO:0007166]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of MAP kinase activity [GO:0043407]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]	membrane raft [GO:0045121]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	membrane raft [GO:0045121]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of MAP kinase activity [GO:0043407]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q9ULW0	reviewed	TPX2_HUMAN	Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100)	TPX2 C20orf1 C20orf2 DIL2 HCA519	Homo sapiens (Human)	747	FUNCTION: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}.		activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; cell division [GO:0051301]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of mitotic spindle organization [GO:0060236]	axon hillock [GO:0043203]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle pole [GO:0000922]	importin-alpha family protein binding [GO:0061676]; protein kinase binding [GO:0019901]	axon hillock [GO:0043203]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle pole [GO:0000922]; importin-alpha family protein binding [GO:0061676]; protein kinase binding [GO:0019901]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; cell division [GO:0051301]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of mitotic spindle organization [GO:0060236]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19208764}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764}. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. {ECO:0000269|PubMed:19208764}.
Q9ULW2	reviewed	FZD10_HUMAN	Frizzled-10 (Fz-10) (hFz10) (FzE7) (CD antigen CD350)	FZD10	Homo sapiens (Human)	581	FUNCTION: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). {ECO:0000250|UniProtKB:Q8BKG4, ECO:0000305}.		canonical Wnt signaling pathway [GO:0060070]; cellular response to retinoic acid [GO:0071300]; negative regulation of GTPase activity [GO:0034260]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; non-canonical Wnt signaling pathway via JNK cascade [GO:0038031]; positive regulation of GTPase activity [GO:0043547]; positive regulation of JUN kinase activity [GO:0043507]; regulation of actin cytoskeleton organization [GO:0032956]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; canonical Wnt signaling pathway [GO:0060070]; cellular response to retinoic acid [GO:0071300]; negative regulation of GTPase activity [GO:0034260]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; non-canonical Wnt signaling pathway via JNK cascade [GO:0038031]; positive regulation of GTPase activity [GO:0043547]; positive regulation of JUN kinase activity [GO:0043507]; regulation of actin cytoskeleton organization [GO:0032956]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:19188438}; Multi-pass membrane protein {ECO:0000255}.
Q9ULW3	reviewed	ABT1_HUMAN	Activator of basal transcription 1 (hABT1) (Basal transcriptional activator)	ABT1	Homo sapiens (Human)	272	FUNCTION: Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). {ECO:0000250}.		endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; regulation of transcription by RNA polymerase II [GO:0006357]; small-subunit processome assembly [GO:0034462]; spinal cord motor neuron differentiation [GO:0021522]; transcription by RNA polymerase II [GO:0006366]	nucleolus [GO:0005730]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	nucleolus [GO:0005730]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; regulation of transcription by RNA polymerase II [GO:0006357]; small-subunit processome assembly [GO:0034462]; spinal cord motor neuron differentiation [GO:0021522]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}.
Q9ULW5	reviewed	RAB26_HUMAN	Ras-related protein Rab-26	RAB26	Homo sapiens (Human)	256	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland. {ECO:0000269|PubMed:20038531, ECO:0000269|PubMed:23105096}.		exocrine system development [GO:0035272]; Golgi to plasma membrane protein transport [GO:0043001]; regulated exocytosis [GO:0045055]; regulation of exocytosis [GO:0017157]; regulation protein catabolic process at presynapse [GO:0140251]	endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]	GMP binding [GO:0019002]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]; GMP binding [GO:0019002]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; exocrine system development [GO:0035272]; Golgi to plasma membrane protein transport [GO:0043001]; regulated exocytosis [GO:0045055]; regulation of exocytosis [GO:0017157]; regulation protein catabolic process at presynapse [GO:0140251]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23105096}; Lipid-anchor {ECO:0000269|PubMed:23105096}; Cytoplasmic side {ECO:0000269|PubMed:23105096}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:23105096}; Lipid-anchor {ECO:0000305|PubMed:23105096}; Cytoplasmic side {ECO:0000305|PubMed:23105096}. Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location. {ECO:0000250|UniProtKB:P51156}.
Q9ULW6	reviewed	NP1L2_HUMAN	Nucleosome assembly protein 1-like 2 (Brain-specific protein, X-linked)	NAP1L2 BPX	Homo sapiens (Human)	460	FUNCTION: Acidic protein which may be involved in interactions with other proteins or DNA. {ECO:0000250}.		neuron differentiation [GO:0030182]; nucleosome assembly [GO:0006334]; positive regulation of neuron differentiation [GO:0045666]; regulation of stem cell division [GO:2000035]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone acetyltransferase regulator activity [GO:0035034]; histone binding [GO:0042393]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone acetyltransferase regulator activity [GO:0035034]; histone binding [GO:0042393]; neuron differentiation [GO:0030182]; nucleosome assembly [GO:0006334]; positive regulation of neuron differentiation [GO:0045666]; regulation of stem cell division [GO:2000035]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9ULW8	reviewed	PADI3_HUMAN	Protein-arginine deiminase type-3 (EC 3.5.3.15) (Peptidylarginine deiminase III) (Protein-arginine deiminase type III)	PADI3 PAD3 PDI3	Homo sapiens (Human)	664	FUNCTION: Catalyzes the deimination of arginine residues of proteins. {ECO:0000269|PubMed:27866708}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein-arginine deiminase activity [GO:0004668]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein-arginine deiminase activity [GO:0004668]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27866708}.
Q9ULX3	reviewed	NOB1_HUMAN	RNA-binding protein NOB1 (EC 3.1.-.-) (Phosphorylation regulatory protein HP-10) (Protein ART-4)	NOB1 ART4 NOB1P PSMD8BP1 MSTP158	Homo sapiens (Human)	412	FUNCTION: May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). {ECO:0000250|UniProtKB:Q9FLL1, ECO:0000305}.		maturation of SSU-rRNA [GO:0030490]; rRNA processing [GO:0006364]; visual perception [GO:0007601]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]	metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]; metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]; maturation of SSU-rRNA [GO:0030490]; rRNA processing [GO:0006364]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16172919}.
Q9ULX5	reviewed	RN112_HUMAN	RING finger protein 112 (EC 2.3.2.27) (Brain finger protein) (Zinc finger protein 179)	RNF112 BFP ZNF179	Homo sapiens (Human)	631	FUNCTION: E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed:28684796). Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (By similarity). {ECO:0000250|UniProtKB:Q96DY5, ECO:0000269|PubMed:28684796}.		embryonic brain development [GO:1990403]; endoplasmic reticulum organization [GO:0007029]; G1 to G0 transition involved in cell differentiation [GO:0070315]; neuron differentiation [GO:0030182]; positive regulation of glial cell differentiation [GO:0045687]; positive regulation of neuron differentiation [GO:0045666]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; regulation of cell cycle [GO:0051726]; response to hydroperoxide [GO:0033194]	cell body [GO:0044297]; cytoplasm [GO:0005737]; endosome [GO:0005768]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein self-association [GO:0043621]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cell body [GO:0044297]; cytoplasm [GO:0005737]; endosome [GO:0005768]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein self-association [GO:0043621]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; embryonic brain development [GO:1990403]; endoplasmic reticulum organization [GO:0007029]; G1 to G0 transition involved in cell differentiation [GO:0070315]; neuron differentiation [GO:0030182]; positive regulation of glial cell differentiation [GO:0045687]; positive regulation of neuron differentiation [GO:0045666]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; regulation of cell cycle [GO:0051726]; response to hydroperoxide [GO:0033194]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q96DY5}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:Q96DY5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96DY5}. Cytoplasm {ECO:0000250|UniProtKB:Q96DY5}. Nucleus {ECO:0000250|UniProtKB:Q96DY5}. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q96DY5}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q96DY5}. Endosome {ECO:0000250|UniProtKB:Q96DY5}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q96DY5}. Postsynaptic density {ECO:0000250|UniProtKB:Q96DY5}. Perikaryon {ECO:0000250|UniProtKB:Q96DY5}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q96DY5}. Note=Predominantly in the nucleus, but some amounts were also found in the cytoplasm. Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus. Recruited to nuclear bodies via its interaction with ZBTB16. Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas. {ECO:0000250|UniProtKB:Q96DY5}.
Q9ULX6	reviewed	AKP8L_HUMAN	A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95)	AKAP8L NAKAP NAKAP95 HRIHFB2018	Homo sapiens (Human)	646	FUNCTION: Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). {ECO:0000269|PubMed:10748171, ECO:0000269|PubMed:11034899, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11884601, ECO:0000269|PubMed:12538639, ECO:0000269|PubMed:16980585, ECO:0000305|PubMed:10761695}.; FUNCTION: (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. {ECO:0000269|PubMed:11884601}.; FUNCTION: (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. {ECO:0000269|PubMed:11402034}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity. {ECO:0000269|PubMed:25034436}.		cell cycle G2/M phase transition [GO:0044839]; mitotic chromosome condensation [GO:0007076]; mRNA processing [GO:0006397]; nuclear membrane disassembly [GO:0051081]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mRNA export from nucleus [GO:0010793]; RNA splicing [GO:0008380]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; ribonucleoprotein complex [GO:1990904]	DEAD/H-box RNA helicase binding [GO:0017151]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; lamin binding [GO:0005521]; metal ion binding [GO:0046872]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; ribonucleoprotein complex [GO:1990904]; DEAD/H-box RNA helicase binding [GO:0017151]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; lamin binding [GO:0005521]; metal ion binding [GO:0046872]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]; cell cycle G2/M phase transition [GO:0044839]; mitotic chromosome condensation [GO:0007076]; mRNA processing [GO:0006397]; nuclear membrane disassembly [GO:0051081]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mRNA export from nucleus [GO:0010793]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10748171, ECO:0000269|PubMed:10761695}. Nucleus matrix {ECO:0000269|PubMed:11034899, ECO:0000269|PubMed:16391387}. Nucleus speckle {ECO:0000269|PubMed:17594903}. Nucleus, PML body {ECO:0000269|PubMed:11884601}. Cytoplasm {ECO:0000269|PubMed:10748171}. Note=Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601). {ECO:0000269|PubMed:10748171, ECO:0000269|PubMed:11034899, ECO:0000269|PubMed:11884601, ECO:0000269|PubMed:16391387}.
Q9ULX7	reviewed	CAH14_HUMAN	Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV)	CA14 UNQ690/PRO1335	Homo sapiens (Human)	337	FUNCTION: Reversible hydration of carbon dioxide.		one-carbon metabolic process [GO:0006730]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]; one-carbon metabolic process [GO:0006730]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9ULX9	reviewed	MAFF_HUMAN	Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F)	MAFF	Homo sapiens (Human)	164	FUNCTION: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:8932385, PubMed:16549056). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846). {ECO:0000269|PubMed:10527846, ECO:0000269|PubMed:16549056, ECO:0000269|PubMed:8932385}.		in utero embryonic development [GO:0001701]; negative regulation of transcription by RNA polymerase II [GO:0000122]; parturition [GO:0007567]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epidermal cell differentiation [GO:0045604]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]	chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; in utero embryonic development [GO:0001701]; negative regulation of transcription by RNA polymerase II [GO:0000122]; parturition [GO:0007567]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epidermal cell differentiation [GO:0045604]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus.
Q9ULY5	reviewed	CLC4E_HUMAN	C-type lectin domain family 4 member E (C-type lectin superfamily member 9) (Macrophage-inducible C-type lectin) (MINCLE)	CLEC4E CLECSF9 MINCLE UNQ218/PRO244	Homo sapiens (Human)	219	FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18509109, PubMed:23602766). The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:23602766, PubMed:24101491). Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation (By similarity). Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (By similarity). {ECO:0000250|UniProtKB:Q9R0Q8, ECO:0000269|PubMed:18509109, ECO:0000269|PubMed:23602766, ECO:0000269|PubMed:24101491}.		antifungal innate immune response [GO:0061760]; defense response to bacterium [GO:0042742]; Fc-gamma receptor signaling pathway [GO:0038094]; innate immune response [GO:0045087]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cytokine production [GO:0001819]; T cell differentiation involved in immune response [GO:0002292]	cell projection [GO:0042995]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; glycolipid binding [GO:0051861]; pattern recognition receptor activity [GO:0038187]	cell projection [GO:0042995]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; glycolipid binding [GO:0051861]; pattern recognition receptor activity [GO:0038187]; antifungal innate immune response [GO:0061760]; defense response to bacterium [GO:0042742]; Fc-gamma receptor signaling pathway [GO:0038094]; innate immune response [GO:0045087]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cytokine production [GO:0001819]; T cell differentiation involved in immune response [GO:0002292]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18490740, ECO:0000305|PubMed:24101491}; Single-pass type II membrane protein {ECO:0000305}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q9R0Q8}.
Q9ULZ1	reviewed	APEL_HUMAN	Apelin (APJ endogenous ligand) [Cleaved into: Apelin-36; Apelin-31; Apelin-28; Apelin-13]	APLN APEL	Homo sapiens (Human)	77	FUNCTION: Endogenous ligand for the apelin receptor (APLNR) (PubMed:10525157). Drives internalization of the apelin receptor (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity). {ECO:0000250|UniProtKB:Q4TTN8, ECO:0000250|UniProtKB:Q9R0R3, ECO:0000250|UniProtKB:Q9R0R4, ECO:0000269|PubMed:10525157}.; FUNCTION: (Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection (PubMed:11090199). Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR (PubMed:11090199). Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives (PubMed:11090199). {ECO:0000269|PubMed:11090199}.		angiogenesis [GO:0001525]; apelin receptor signaling pathway [GO:0060183]; coronary vasculature development [GO:0060976]; drinking behavior [GO:0042756]; gastrulation [GO:0007369]; immune response [GO:0006955]; lactation [GO:0007595]; negative regulation of blood pressure [GO:0045776]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression [GO:0010629]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of G protein-coupled receptor internalization [GO:1904022]; positive regulation of heart contraction [GO:0045823]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	apelin receptor binding [GO:0031704]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; apelin receptor binding [GO:0031704]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; angiogenesis [GO:0001525]; apelin receptor signaling pathway [GO:0060183]; coronary vasculature development [GO:0060976]; drinking behavior [GO:0042756]; gastrulation [GO:0007369]; immune response [GO:0006955]; lactation [GO:0007595]; negative regulation of blood pressure [GO:0045776]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression [GO:0010629]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of G protein-coupled receptor internalization [GO:1904022]; positive regulation of heart contraction [GO:0045823]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9TUI9}. Secreted, extracellular space {ECO:0000250|UniProtKB:Q9TUI9}. Note=Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk. {ECO:0000250|UniProtKB:Q9TUI9}.
Q9ULZ2	reviewed	STAP1_HUMAN	Signal-transducing adaptor protein 1 (STAP-1) (BCR downstream-signaling protein 1) (Docking protein BRDG1) (Stem cell adaptor protein 1)	STAP1 BRDG1	Homo sapiens (Human)	295	FUNCTION: In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. {ECO:0000269|PubMed:10518561}.		cellular response to lipopolysaccharide [GO:0071222]; negative regulation of macrophage chemotaxis [GO:0010760]; negative regulation of macrophage colony-stimulating factor signaling pathway [GO:1902227]; negative regulation of microglial cell migration [GO:1904140]; negative regulation of phosphorylation [GO:0042326]; negative regulation of ruffle assembly [GO:1900028]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of gene expression [GO:0010628]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of phagocytosis, engulfment [GO:0060100]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	macrophage colony-stimulating factor receptor binding [GO:0005157]; phospholipid binding [GO:0005543]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase activator activity [GO:0030296]; signaling adaptor activity [GO:0035591]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; macrophage colony-stimulating factor receptor binding [GO:0005157]; phospholipid binding [GO:0005543]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase activator activity [GO:0030296]; signaling adaptor activity [GO:0035591]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of macrophage chemotaxis [GO:0010760]; negative regulation of macrophage colony-stimulating factor signaling pathway [GO:1902227]; negative regulation of microglial cell migration [GO:1904140]; negative regulation of phosphorylation [GO:0042326]; negative regulation of ruffle assembly [GO:1900028]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of gene expression [GO:0010628]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of phagocytosis, engulfment [GO:0060100]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17936702}. Cytoplasm {ECO:0000269|PubMed:17936702}. Mitochondrion {ECO:0000269|PubMed:17936702}.
Q9ULZ3	reviewed	ASC_HUMAN	Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)	PYCARD ASC CARD5 TMS1	Homo sapiens (Human)	195	FUNCTION: Functions as key mediator in apoptosis and inflammation (PubMed:17599095, PubMed:25847972, PubMed:19494289, PubMed:15030775, PubMed:17349957, PubMed:19158675, PubMed:19158676, PubMed:30674671, PubMed:34678144, PubMed:24630722, PubMed:21487011, PubMed:19234215, PubMed:11103777, PubMed:12646168). Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner (PubMed:11103777, PubMed:12646168). Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3 (PubMed:16964285, PubMed:14730312). Involved in innate immune response by acting as an integral adapter in the assembly of various inflammasomes (NLRP1, NLRP2, NLRP3, NLRP6, AIM2 and probably IFI16) which recruit and activate caspase-1 leading to processing and secretion of pro-inflammatory cytokines (PubMed:17599095, PubMed:25847972, PubMed:15030775, PubMed:17349957, PubMed:19158675, PubMed:19158676, PubMed:30674671, PubMed:34678144, PubMed:16982856, PubMed:24630722, PubMed:21487011, PubMed:19234215, PubMed:23530044, PubMed:29440442, PubMed:33980849). Caspase-1-dependent inflammation leads to macrophage pyroptosis, a form of cell death (PubMed:24630722). The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions (PubMed:19234215, PubMed:14499617, PubMed:24630722). Clustered PYCARD nucleates the formation of caspase-1 filaments through the interaction of their respective CARD domains, acting as a platform for of caspase-1 polymerization (PubMed:24630722). In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1 (PubMed:17349957). In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation (PubMed:16964285). May be involved in RIGI-triggered pro-inflammatory responses and inflammasome activation (PubMed:19915568). In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8 (PubMed:19158675, PubMed:19158676). In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form (PubMed:22732093). Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways (PubMed:12486103, PubMed:16585594). For regulation of NF-kappa-B activating and inhibiting functions have been reported (PubMed:12486103). Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK (PubMed:12486103, PubMed:16585594). Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing (PubMed:16585594). Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating CGAS in presence of cytoplasmic double-stranded DNA (PubMed:28314590). {ECO:0000269|PubMed:11103777, ECO:0000269|PubMed:12486103, ECO:0000269|PubMed:12646168, ECO:0000269|PubMed:14499617, ECO:0000269|PubMed:14730312, ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:16585594, ECO:0000269|PubMed:16964285, ECO:0000269|PubMed:16982856, ECO:0000269|PubMed:17349957, ECO:0000269|PubMed:17599095, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19234215, ECO:0000269|PubMed:19494289, ECO:0000269|PubMed:19915568, ECO:0000269|PubMed:21487011, ECO:0000269|PubMed:22732093, ECO:0000269|PubMed:23530044, ECO:0000269|PubMed:24630722, ECO:0000269|PubMed:25847972, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:29440442, ECO:0000269|PubMed:30674671, ECO:0000269|PubMed:33980849, ECO:0000269|PubMed:34678144}.; FUNCTION: [Isoform 2]: May have a regulating effect on the function as inflammasome adapter. {ECO:0000269|PubMed:19759850, ECO:0000269|PubMed:20482797}.; FUNCTION: [Isoform 3]: Seems to inhibit inflammasome-mediated maturation of interleukin-1 beta. {ECO:0000269|PubMed:20482797}.	MISCELLANEOUS: In breast tumorigenesis, methylation-mediated silencing may affect genes and proteins that act as positive mediators of cell death.	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; icosanoid biosynthetic process [GO:0046456]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; macropinocytosis [GO:0044351]; myeloid dendritic cell activation [GO:0001773]; myeloid dendritic cell activation involved in immune response [GO:0002277]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; NLRP3 inflammasome complex assembly [GO:0044546]; osmosensory signaling pathway [GO:0007231]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002588]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chemokine production [GO:0032722]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phagocytosis [GO:0050766]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell migration [GO:2000406]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; protein homooligomerization [GO:0051260]; pyroptosis [GO:0070269]; regulation of autophagy [GO:0010506]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; regulation of protein stability [GO:0031647]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	AIM2 inflammasome complex [GO:0097169]; azurophil granule lumen [GO:0035578]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; IkappaB kinase complex [GO:0008385]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; NLRP1 inflammasome complex [GO:0072558]; NLRP3 inflammasome complex [GO:0072559]; NLRP6 inflammasome complex [GO:0140738]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]	BMP receptor binding [GO:0070700]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; interleukin-6 receptor binding [GO:0005138]; myosin I binding [GO:0017024]; protease binding [GO:0002020]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; Pyrin domain binding [GO:0032090]; transmembrane transporter binding [GO:0044325]; tropomyosin binding [GO:0005523]	AIM2 inflammasome complex [GO:0097169]; azurophil granule lumen [GO:0035578]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; IkappaB kinase complex [GO:0008385]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; NLRP1 inflammasome complex [GO:0072558]; NLRP3 inflammasome complex [GO:0072559]; NLRP6 inflammasome complex [GO:0140738]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; BMP receptor binding [GO:0070700]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; interleukin-6 receptor binding [GO:0005138]; myosin I binding [GO:0017024]; protease binding [GO:0002020]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; Pyrin domain binding [GO:0032090]; transmembrane transporter binding [GO:0044325]; tropomyosin binding [GO:0005523]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; icosanoid biosynthetic process [GO:0046456]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; macropinocytosis [GO:0044351]; myeloid dendritic cell activation [GO:0001773]; myeloid dendritic cell activation involved in immune response [GO:0002277]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; NLRP3 inflammasome complex assembly [GO:0044546]; osmosensory signaling pathway [GO:0007231]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002588]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chemokine production [GO:0032722]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phagocytosis [GO:0050766]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell migration [GO:2000406]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; protein homooligomerization [GO:0051260]; pyroptosis [GO:0070269]; regulation of autophagy [GO:0010506]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; regulation of protein stability [GO:0031647]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11103777, ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:19234215, ECO:0000269|PubMed:25847972}. Inflammasome {ECO:0000269|PubMed:12191486, ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:30674671, ECO:0000269|PubMed:34678144}. Endoplasmic reticulum {ECO:0000269|PubMed:21124315}. Mitochondrion {ECO:0000269|PubMed:14730312, ECO:0000269|PubMed:21124315}. Nucleus {ECO:0000269|PubMed:19234215, ECO:0000269|PubMed:25847972}. Note=Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures (PubMed:11103777, PubMed:12191486, PubMed:15030775). Upon NLRP3 inflammasome activation redistributes to the perinuclear space localizing to endoplasmic reticulum and mitochondria (PubMed:12191486, PubMed:15030775). Localized primarily to the nucleus in resting monocytes/macrophages and rapidly redistributed to the cytoplasm upon pathogen infection (PubMed:19234215). Localized to large cytoplasmic aggregate appearing as a speck containing AIM2, PYCARD, CASP8 and bacterial DNA after infection with Francisella tularensis (By similarity). {ECO:0000250|UniProtKB:Q9EPB4, ECO:0000269|PubMed:11103777, ECO:0000269|PubMed:12191486, ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:19234215}.; SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23229815}. Note=(Microbial infection) Upon HRSV infection, the protein is mainly located in lipid rafts in the Golgi membrane. {ECO:0000269|PubMed:23229815}.
Q9ULZ9	reviewed	MMP17_HUMAN	Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP)	MMP17 MT4MMP	Homo sapiens (Human)	603	FUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.		collagen catabolic process [GO:0030574]; drinking behavior [GO:0042756]; extracellular matrix organization [GO:0030198]; kidney development [GO:0001822]; proteolysis [GO:0006508]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; collagen catabolic process [GO:0030574]; drinking behavior [GO:0042756]; extracellular matrix organization [GO:0030198]; kidney development [GO:0001822]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
Q9UM00	reviewed	TMCO1_HUMAN	Calcium load-activated calcium channel (CLAC channel) (GEL complex subunit TMCO1) (Transmembrane and coiled-coil domain-containing protein 1) (Transmembrane and coiled-coil domains protein 4) (Xenogeneic cross-immune protein PCIA3)	TMCO1 TMCC4 PNAS-10 PNAS-136 UNQ151/PRO177	Homo sapiens (Human)	239	FUNCTION: Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum (ER) overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed:27212239). Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (PubMed:36261522). {ECO:0000269|PubMed:27212239, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.		calcium ion transmembrane transport [GO:0070588]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; ER overload response [GO:0006983]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; multi-pass translocon complex [GO:0160064]	calcium channel activity [GO:0005262]; ribosome binding [GO:0043022]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; multi-pass translocon complex [GO:0160064]; calcium channel activity [GO:0005262]; ribosome binding [GO:0043022]; calcium ion transmembrane transport [GO:0070588]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; ER overload response [GO:0006983]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10393320, ECO:0000269|PubMed:27212239, ECO:0000269|PubMed:36261522}; Multi-pass membrane protein {ECO:0000269|PubMed:10393320, ECO:0000269|PubMed:27212239}. Golgi apparatus membrane {ECO:0000269|PubMed:10393320}; Multi-pass membrane protein {ECO:0000269|PubMed:10393320}. Note=The first transmembrane region is required for localization to the endoplasmic reticulum (PubMed:27212239). A publication reported localization in cytoplasm and nucleus (PubMed:22714896). Nuclear localization is however in contradiction with two other reports (PubMed:10393320, PubMed:27212239). {ECO:0000269|PubMed:10393320, ECO:0000269|PubMed:22714896, ECO:0000269|PubMed:27212239}.
Q9UM01	reviewed	YLAT1_HUMAN	Y+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1)	SLC7A7	Homo sapiens (Human)	511	FUNCTION: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:9878049, PubMed:9829974, PubMed:17329401, PubMed:10080182, PubMed:10655553, PubMed:15756301, PubMed:15776427, PubMed:14603368). Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (PubMed:15280038, PubMed:31705628). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity). {ECO:0000250|UniProtKB:Q9R0S5, ECO:0000269|PubMed:10080182, ECO:0000269|PubMed:10655553, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:15776427, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.		amino acid transmembrane transport [GO:0003333]; basic amino acid transmembrane transport [GO:1990822]; L-arginine transmembrane transport [GO:1903826]; leucine transport [GO:0015820]; regulation of arginine metabolic process [GO:0000821]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; amino acid transmembrane transport [GO:0003333]; basic amino acid transmembrane transport [GO:1990822]; L-arginine transmembrane transport [GO:1903826]; leucine transport [GO:0015820]; regulation of arginine metabolic process [GO:0000821]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:15756301}; Multi-pass membrane protein {ECO:0000255}.
Q9UM07	reviewed	PADI4_HUMAN	Protein-arginine deiminase type-4 (EC 3.5.3.15) (HL-60 PAD) (Peptidylarginine deiminase IV) (Protein-arginine deiminase type IV)	PADI4 PAD4 PADI5 PDI5	Homo sapiens (Human)	663	FUNCTION: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci) (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (PubMed:18209087). Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription (PubMed:15345777). Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 (PubMed:15731352). {ECO:0000250|UniProtKB:Q9Z183, ECO:0000269|PubMed:15339660, ECO:0000269|PubMed:15345777, ECO:0000269|PubMed:15731352, ECO:0000269|PubMed:16567635, ECO:0000269|PubMed:18209087, ECO:0000269|PubMed:21245532}.		chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; innate immune response [GO:0045087]; nucleosome assembly [GO:0006334]; post-translational protein modification [GO:0043687]; protein modification process [GO:0036211]; stem cell population maintenance [GO:0019827]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	calcium ion binding [GO:0005509]; histone arginine deiminase activity [GO:0140794]; histone H3R17 arginine deiminase activity [GO:0140797]; histone H3R2 arginine deiminase activity [GO:0140795]; histone H3R26 arginine deiminase activity [GO:0140798]; histone H3R8 arginine deiminase activity [GO:0140796]; identical protein binding [GO:0042802]; protein-arginine deiminase activity [GO:0004668]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; calcium ion binding [GO:0005509]; histone arginine deiminase activity [GO:0140794]; histone H3R17 arginine deiminase activity [GO:0140797]; histone H3R2 arginine deiminase activity [GO:0140795]; histone H3R26 arginine deiminase activity [GO:0140798]; histone H3R8 arginine deiminase activity [GO:0140796]; identical protein binding [GO:0042802]; protein-arginine deiminase activity [GO:0004668]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; innate immune response [GO:0045087]; nucleosome assembly [GO:0006334]; post-translational protein modification [GO:0043687]; protein modification process [GO:0036211]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15629448}. Nucleus {ECO:0000269|PubMed:15629448}. Cytoplasmic granule {ECO:0000269|PubMed:11435484}. Note=Cytoplasmic granules of eosinophils and neutrophils. {ECO:0000269|PubMed:11435484}.
Q9UM11	reviewed	FZR1_HUMAN	Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1)	FZR1 CDH1 FYR FZR KIAA1242	Homo sapiens (Human)	496	FUNCTION: Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192). {ECO:0000269|PubMed:14701726, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:25349192, ECO:0000269|PubMed:9734353}.	MISCELLANEOUS: [Isoform 2]: Major. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Minor. {ECO:0000305}.	anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; DNA repair [GO:0006281]; lens fiber cell differentiation [GO:0070306]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cellular senescence [GO:2000773]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of meiotic nuclear division [GO:0040020]; regulation of mitotic cell cycle [GO:0007346]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; DNA repair [GO:0006281]; lens fiber cell differentiation [GO:0070306]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cellular senescence [GO:2000773]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of meiotic nuclear division [GO:0040020]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:34788397}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Q9UM13	reviewed	APC10_HUMAN	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10)	ANAPC10 APC10	Homo sapiens (Human)	185	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]		anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	
Q9UM19	reviewed	HPCL4_HUMAN	Hippocalcin-like protein 4 (HLP4)	HPCAL4	Homo sapiens (Human)	191	FUNCTION: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. {ECO:0000250}.	MISCELLANEOUS: Probably binds two or three calcium ions. {ECO:0000250}.	central nervous system development [GO:0007417]		calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; protein domain specific binding [GO:0019904]	calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; protein domain specific binding [GO:0019904]; central nervous system development [GO:0007417]	
Q9UM21	reviewed	MGT4A_HUMAN	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa) (GlcNAc-T IVa) (GnT-IVa) (N-acetylglucosaminyltransferase IVa) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa) [Cleaved into: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form]	MGAT4A	Homo sapiens (Human)	535	FUNCTION: Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:17006639). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity). {ECO:0000250|UniProtKB:Q812G0, ECO:0000269|PubMed:17006639}.		glyoxylate metabolic process [GO:0046487]; N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; peroxisome [GO:0005777]	acetylglucosaminyltransferase activity [GO:0008375]; alanine-glyoxylate transaminase activity [GO:0008453]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; peroxisome [GO:0005777]; acetylglucosaminyltransferase activity [GO:0008375]; alanine-glyoxylate transaminase activity [GO:0008453]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; glyoxylate metabolic process [GO:0046487]; N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: [Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A]: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9D4R2}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9D4R2}.; SUBCELLULAR LOCATION: [Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form]: Secreted {ECO:0000250|UniProtKB:O77836}.
Q9UM22	reviewed	EPDR1_HUMAN	Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein)	EPDR1 MERP1 UCC1	Homo sapiens (Human)	224	FUNCTION: Binds anionic lipids and gangliosides at acidic pH. {ECO:0000269|PubMed:30729188}.		cell-matrix adhesion [GO:0007160]; myofibroblast contraction [GO:1990764]	extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	calcium ion binding [GO:0005509]; ganglioside GM1 binding [GO:1905573]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]	extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; calcium ion binding [GO:0005509]; ganglioside GM1 binding [GO:1905573]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; cell-matrix adhesion [GO:0007160]; myofibroblast contraction [GO:1990764]	SUBCELLULAR LOCATION: Lysosome lumen {ECO:0000269|PubMed:30729188}. Secreted {ECO:0000269|PubMed:30729188}. Note=Lysosomal and also secreted. {ECO:0000269|PubMed:30729188}.
Q9UM44	reviewed	HHLA2_HUMAN	HERV-H LTR-associating protein 2 (Human endogenous retrovirus-H long terminal repeat-associating protein 2)	HHLA2	Homo sapiens (Human)	414	FUNCTION: Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:23784006}.		positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cytokine production [GO:0001819]; regulation of cytokine production [GO:0001817]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; signaling receptor binding [GO:0005102]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cytokine production [GO:0001819]; regulation of cytokine production [GO:0001817]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9UM47	reviewed	NOTC3_HUMAN	Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]	NOTCH3	Homo sapiens (Human)	2321	FUNCTION: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250|UniProtKB:Q9R172, ECO:0000269|PubMed:15350543}.		artery morphogenesis [GO:0048844]; axon guidance [GO:0007411]; forebrain development [GO:0030900]; glomerular capillary formation [GO:0072104]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast differentiation [GO:0014016]; neuron fate commitment [GO:0048663]; Notch signaling pathway [GO:0007219]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; artery morphogenesis [GO:0048844]; axon guidance [GO:0007411]; forebrain development [GO:0030900]; glomerular capillary formation [GO:0072104]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast differentiation [GO:0014016]; neuron fate commitment [GO:0048663]; Notch signaling pathway [GO:0007219]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15350543}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Notch 3 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.
Q9UM54	reviewed	MYO6_HUMAN	Unconventional myosin-VI (Unconventional myosin-6)	MYO6 KIAA0389	Homo sapiens (Human)	1294	FUNCTION: Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:29467281, ECO:0000269|PubMed:31371777}.		actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; endocytosis [GO:0006897]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; intracellular protein transport [GO:0006886]; regulation of secretion [GO:0051046]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; vesicle transport along actin filament [GO:0030050]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; apical part of cell [GO:0045177]; autophagosome [GO:0005776]; cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus [GO:0005902]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; unconventional myosin complex [GO:0016461]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; cytoskeletal motor activity [GO:0003774]; identical protein binding [GO:0042802]; microfilament motor activity [GO:0000146]; minus-end directed microfilament motor activity [GO:0060001]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; apical part of cell [GO:0045177]; autophagosome [GO:0005776]; cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus [GO:0005902]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; unconventional myosin complex [GO:0016461]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; cytoskeletal motor activity [GO:0003774]; identical protein binding [GO:0042802]; microfilament motor activity [GO:0000146]; minus-end directed microfilament motor activity [GO:0060001]; actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; endocytosis [GO:0006897]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; intracellular protein transport [GO:0006886]; regulation of secretion [GO:0051046]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; vesicle transport along actin filament [GO:0030050]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16507995}; Peripheral membrane protein {ECO:0000269|PubMed:16507995}. Golgi apparatus {ECO:0000269|PubMed:16507995}. Nucleus {ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16507995}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:11447109}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:11447109}. Cell projection, filopodium {ECO:0000269|PubMed:9852149}. Cell projection, ruffle membrane {ECO:0000269|PubMed:16507995}. Cell projection, microvillus {ECO:0000269|PubMed:9852149}. Cytoplasm, cytosol {ECO:0000269|PubMed:16949370}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:23023224}. Endosome {ECO:0000269|PubMed:23023224}. Note=Also present in endocyctic vesicles (PubMed:16507995). Translocates from membrane ruffles, endocytic vesicles and cytoplasm to Golgi apparatus, perinuclear membrane and nucleus through induction by p53 and p53-induced DNA damage (PubMed:16507995). Recruited into membrane ruffles from cell surface by EGF-stimulation (PubMed:9852149). Colocalizes with DAB2 in clathrin-coated pits/vesicles (PubMed:11967127). Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane (By similarity). Recruited to endosomes by TOM1 and TOM1L2 (PubMed:23023224). {ECO:0000250|UniProtKB:Q9I8D1, ECO:0000269|PubMed:11967127, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:9852149}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:11447109}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasmic vesicle, clathrin-coated vesicle membrane. Cell projection, ruffle membrane {ECO:0000269|PubMed:11447109}.
Q9UM63	reviewed	PLAL1_HUMAN	Zinc finger protein PLAGL1 (Lost on transformation 1) (LOT-1) (Pleiomorphic adenoma-like protein 1) (Tumor suppressor ZAC)	PLAGL1 LOT1 ZAC	Homo sapiens (Human)	463	FUNCTION: Acts as a transcriptional activator (PubMed:9722527). Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide. {ECO:0000269|PubMed:18299245, ECO:0000269|PubMed:9722527}.		apoptotic process [GO:0006915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; apoptotic process [GO:0006915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11313869, ECO:0000269|PubMed:18299245}.
Q9UM73	reviewed	ALK_HUMAN	ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)	ALK	Homo sapiens (Human)	1620	FUNCTION: Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). In contrast, ALKAL1 is not a potent physiological ligand for ALK (PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:34819673). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (PubMed:15226403, PubMed:16878150). Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 (PubMed:15226403, PubMed:16878150). ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK) (PubMed:11278720, PubMed:11809760, PubMed:12107166, PubMed:12122009). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720, PubMed:11809760, PubMed:12107166). MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction (PubMed:12122009). Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase (PubMed:15226403, PubMed:16878150). Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (PubMed:15226403, PubMed:16878150). {ECO:0000250|UniProtKB:P97793, ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760, ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}.		adult behavior [GO:0030534]; energy homeostasis [GO:0097009]; hippocampus development [GO:0021766]; negative regulation of lipid catabolic process [GO:0050995]; neuron development [GO:0048666]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphorylation [GO:0016310]; positive regulation of dendrite development [GO:1900006]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of neuron differentiation [GO:0045664]; response to environmental enrichment [GO:0090648]; signal transduction [GO:0007165]; swimming behavior [GO:0036269]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; NF-kappaB-inducing kinase activity [GO:0004704]; protein tyrosine kinase activity [GO:0004713]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; NF-kappaB-inducing kinase activity [GO:0004704]; protein tyrosine kinase activity [GO:0004713]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; adult behavior [GO:0030534]; energy homeostasis [GO:0097009]; hippocampus development [GO:0021766]; negative regulation of lipid catabolic process [GO:0050995]; neuron development [GO:0048666]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphorylation [GO:0016310]; positive regulation of dendrite development [GO:1900006]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of neuron differentiation [GO:0045664]; response to environmental enrichment [GO:0090648]; signal transduction [GO:0007165]; swimming behavior [GO:0036269]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:34819673, ECO:0000269|PubMed:9174053}; Single-pass type I membrane protein {ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:9174053}. Note=Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. {ECO:0000269|PubMed:16317043}.
Q9UM82	reviewed	SPAT2_HUMAN	Spermatogenesis-associated protein 2	SPATA2 KIAA0757 PD1	Homo sapiens (Human)	520	FUNCTION: Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity). {ECO:0000250|UniProtKB:Q8K004, ECO:0000269|PubMed:27307491, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27545878, ECO:0000269|PubMed:27591049}.		necroptotic process [GO:0070266]; protein K63-linked deubiquitination [GO:0070536]; protein linear deubiquitination [GO:1990108]; regulation of inflammatory response [GO:0050727]; regulation of necroptotic process [GO:0060544]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]	protein-containing complex binding [GO:0044877]; signaling receptor complex adaptor activity [GO:0030159]; ubiquitin-specific protease binding [GO:1990381]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; protein-containing complex binding [GO:0044877]; signaling receptor complex adaptor activity [GO:0030159]; ubiquitin-specific protease binding [GO:1990381]; necroptotic process [GO:0070266]; protein K63-linked deubiquitination [GO:0070536]; protein linear deubiquitination [GO:1990108]; regulation of inflammatory response [GO:0050727]; regulation of necroptotic process [GO:0060544]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10222154, ECO:0000269|PubMed:11079456}. Nucleus {ECO:0000250|UniProtKB:Q66HP6}. Note=Detected in the tubular compartment of the testis and, in the cytoplasm of the Sertoli cells. {ECO:0000269|PubMed:11079456}.
Q9UMD9	reviewed	COHA1_HUMAN	Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)]	COL17A1 BP180 BPAG2	Homo sapiens (Human)	1497	FUNCTION: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.	MISCELLANEOUS: Both the 120 kDa linear IgA disease antigen and the 97 kDa linear IgA disease antigen of COL17A1, represent major antigenic targets of autoantibodies in patients with linear IgA disease (LAD). LAD is a subepidermal blistering disorder characterized by tissue-bound and circulating IgA autoantibodies to the dermal-epidermal junction. These IgA autoantibodies preferentially react with 97 and the 120 kDa forms, but not with the full-length COL17A1, suggesting that the cleavage of the ectodomain generates novel autoantigenic epitopes.	cell-matrix adhesion [GO:0007160]; epidermis development [GO:0008544]; extracellular matrix organization [GO:0030198]; hemidesmosome assembly [GO:0031581]	basement membrane [GO:0005604]; cell-cell junction [GO:0005911]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; hemidesmosome [GO:0030056]; plasma membrane [GO:0005886]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]	basement membrane [GO:0005604]; cell-cell junction [GO:0005911]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; hemidesmosome [GO:0030056]; plasma membrane [GO:0005886]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; cell-matrix adhesion [GO:0007160]; epidermis development [GO:0008544]; extracellular matrix organization [GO:0030198]; hemidesmosome assembly [GO:0031581]	SUBCELLULAR LOCATION: Cell junction, hemidesmosome. Membrane; Single-pass type II membrane protein. Note=Localized along the plasma membrane of the hemidesmosome.; SUBCELLULAR LOCATION: [120 kDa linear IgA disease antigen]: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Exclusively localized to anchoring filaments. Localized to the epidermal side of split skin.; SUBCELLULAR LOCATION: [97 kDa linear IgA disease antigen]: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Localized in the lamina lucida beneath the hemidesmosomes.
Q9UMF0	reviewed	ICAM5_HUMAN	Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin)	ICAM5 TLCN TLN	Homo sapiens (Human)	924	FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).		cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; phagocytosis [GO:0006909]; regulation of synapse assembly [GO:0051963]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; phagocytosis [GO:0006909]; regulation of synapse assembly [GO:0051963]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9UMN6	reviewed	KMT2B_HUMAN	Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)	KMT2B HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7	Homo sapiens (Human)	2715	FUNCTION: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:17707229). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.		methylation [GO:0032259]; positive regulation of DNA-templated transcription [GO:0045893]	histone methyltransferase complex [GO:0035097]; MLL1/2 complex [GO:0044665]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]	histone methyltransferase complex [GO:0035097]; MLL1/2 complex [GO:0044665]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]; methylation [GO:0032259]; positive regulation of DNA-templated transcription [GO:0045893]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23508102}.
Q9UMQ3	reviewed	BARX2_HUMAN	Homeobox protein BarH-like 2	BARX2	Homo sapiens (Human)	279	FUNCTION: Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity). {ECO:0000250}.		cartilage condensation [GO:0001502]; myotube differentiation [GO:0014902]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase II [GO:0006366]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; cartilage condensation [GO:0001502]; myotube differentiation [GO:0014902]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
Q9UMQ6	reviewed	CAN11_HUMAN	Calpain-11 (EC 3.4.22.-) (Calcium-activated neutral proteinase 11) (CANP 11)	CAPN11	Homo sapiens (Human)	739	FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.		proteolysis [GO:0006508]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; peptidase activity [GO:0008233]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; peptidase activity [GO:0008233]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.
Q9UMR2	reviewed	DD19B_HUMAN	ATP-dependent RNA helicase DDX19B (EC 3.6.4.13) (DEAD box RNA helicase DEAD5) (DEAD box protein 19B)	DDX19B DBP5 DDX19 TDBP	Homo sapiens (Human)	479	FUNCTION: ATP-dependent RNA helicase involved in mRNA export from the nucleus (PubMed:10428971). Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (PubMed:10428971). {ECO:0000269|PubMed:10428971}.		mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10428971}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10428971}. Note=Associates with the nuclear pore complex cytoplasmic fibrils. {ECO:0000269|PubMed:10428971}.
Q9UMR3	reviewed	TBX20_HUMAN	T-box transcription factor TBX20 (T-box protein 20)	TBX20	Homo sapiens (Human)	447	FUNCTION: Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart. {ECO:0000250}.		aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; atrioventricular canal development [GO:0036302]; atrioventricular valve development [GO:0003171]; blood circulation [GO:0008015]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac chamber formation [GO:0003207]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum development [GO:0003279]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube elongation [GO:0036306]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; endoderm formation [GO:0001706]; foramen ovale closure [GO:0035922]; heart looping [GO:0001947]; lateral mesoderm formation [GO:0048370]; mesenchymal cell development [GO:0014031]; motor neuron migration [GO:0097475]; muscle contraction [GO:0006936]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle process [GO:0090068]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; pulmonary valve formation [GO:0003193]; pulmonary vein morphogenesis [GO:0060577]; regulation of transcription by RNA polymerase II [GO:0006357]; tricuspid valve development [GO:0003175]; vasculogenesis [GO:0001570]; visceral motor neuron differentiation [GO:0021524]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; atrioventricular canal development [GO:0036302]; atrioventricular valve development [GO:0003171]; blood circulation [GO:0008015]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac chamber formation [GO:0003207]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum development [GO:0003279]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube elongation [GO:0036306]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; endoderm formation [GO:0001706]; foramen ovale closure [GO:0035922]; heart looping [GO:0001947]; lateral mesoderm formation [GO:0048370]; mesenchymal cell development [GO:0014031]; motor neuron migration [GO:0097475]; muscle contraction [GO:0006936]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle process [GO:0090068]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; pulmonary valve formation [GO:0003193]; pulmonary vein morphogenesis [GO:0060577]; regulation of transcription by RNA polymerase II [GO:0006357]; tricuspid valve development [GO:0003175]; vasculogenesis [GO:0001570]; visceral motor neuron differentiation [GO:0021524]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Q9UMR5	reviewed	PPT2_HUMAN	Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.-) (S-thioesterase G14)	PPT2	Homo sapiens (Human)	302	FUNCTION: Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. {ECO:0000269|PubMed:10417332, ECO:0000269|PubMed:12855696, ECO:0000269|PubMed:9341199}.	MISCELLANEOUS: [Isoform 2]: Catalytically inactive due to lack of His-283. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	fatty-acyl-CoA biosynthetic process [GO:0046949]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	palmitoyl hydrolase activity [GO:0098599]; thiolester hydrolase activity [GO:0016790]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; palmitoyl hydrolase activity [GO:0098599]; thiolester hydrolase activity [GO:0016790]; fatty-acyl-CoA biosynthetic process [GO:0046949]	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:9341199}.
Q9UMR7	reviewed	CLC4A_HUMAN	C-type lectin domain family 4 member A (C-type lectin DDB27) (C-type lectin superfamily member 6) (Dendritic cell immunoreceptor) (Lectin-like immunoreceptor) (CD antigen CD367)	CLEC4A CLECSF6 DCIR LLIR HDCGC13P	Homo sapiens (Human)	237	FUNCTION: C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner (PubMed:27015765). Involved in regulating immune reactivity (PubMed:18258799, PubMed:10438934). Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 (PubMed:18258799, PubMed:20530286). In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (PubMed:18258799). May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:10438934). {ECO:0000269|PubMed:10438934, ECO:0000269|PubMed:18258799, ECO:0000269|PubMed:20530286, ECO:0000269|PubMed:27015765}.; FUNCTION: (Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases. {ECO:0000269|PubMed:21536857}.		adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; CD8-positive, alpha-beta T cell activation [GO:0036037]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of cytokine production [GO:0001818]; negative regulation of tumor necrosis factor production [GO:0032720]; plasmacytoid dendritic cell antigen processing and presentation [GO:0002470]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; mannose binding [GO:0005537]; transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; mannose binding [GO:0005537]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; CD8-positive, alpha-beta T cell activation [GO:0036037]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of cytokine production [GO:0001818]; negative regulation of tumor necrosis factor production [GO:0032720]; plasmacytoid dendritic cell antigen processing and presentation [GO:0002470]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18258799}; Single-pass type II membrane protein {ECO:0000305}; Extracellular side {ECO:0000269|PubMed:18258799}.
Q9UMS0	reviewed	NFU1_HUMAN	NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (HIRA-interacting protein 5)	NFU1 HIRIP5 CGI-33	Homo sapiens (Human)	254	FUNCTION: Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins. {ECO:0000269|PubMed:12886008, ECO:0000269|PubMed:27818104, ECO:0000269|PubMed:28906594}.		iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428]	SUBCELLULAR LOCATION: Mitochondrion. Cytoplasm, cytosol.
Q9UMS4	reviewed	PRP19_HUMAN	Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)	PRPF19 NMP200 PRP19 SNEV	Homo sapiens (Human)	504	FUNCTION: Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961, PubMed:30705154). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity). {ECO:0000250|UniProtKB:Q99KP6, ECO:0000250|UniProtKB:Q9JMJ4, ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:12960389, ECO:0000269|PubMed:15660529, ECO:0000269|PubMed:16223718, ECO:0000269|PubMed:16332694, ECO:0000269|PubMed:16388800, ECO:0000269|PubMed:17349974, ECO:0000269|PubMed:18263876, ECO:0000269|PubMed:21536736, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30705154, ECO:0000303|PubMed:17981804, ECO:0000303|PubMed:20595234}.		DNA damage checkpoint signaling [GO:0000077]; double-strand break repair via nonhomologous end joining [GO:0006303]; lipid biosynthetic process [GO:0008610]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; proteasomal protein catabolic process [GO:0010498]; protein K63-linked ubiquitination [GO:0070534]; protein localization [GO:0008104]; protein polyubiquitination [GO:0000209]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; site of double-strand break [GO:0035861]; spindle [GO:0005819]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; site of double-strand break [GO:0035861]; spindle [GO:0005819]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]; DNA damage checkpoint signaling [GO:0000077]; double-strand break repair via nonhomologous end joining [GO:0006303]; lipid biosynthetic process [GO:0008610]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; proteasomal protein catabolic process [GO:0010498]; protein K63-linked ubiquitination [GO:0070534]; protein localization [GO:0008104]; protein polyubiquitination [GO:0000209]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30705154}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11082287}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11082287}. Cytoplasm {ECO:0000269|PubMed:11435423}. Lipid droplet {ECO:0000250|UniProtKB:Q99KP6}. Note=Nucleoplasmic in interphase cells. Irregularly distributed in anaphase cells. In prophase cells, uniformly distributed, but not associated with condensing chromosomes. Found in extrachromosomal regions in metaphase cells. Mainly localized to the mitotic spindle apparatus when chromosomes segregate during anaphase. When nuclei reform during late telophase, uniformly distributed in daughter cells and displays no preferred association with decondensing chromatin. Recruited on damaged DNA at sites of double-strand break. {ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:18263876}.
Q9UMS6	reviewed	SYNP2_HUMAN	Synaptopodin-2 (Genethonin-2) (Myopodin)	SYNPO2	Homo sapiens (Human)	1093	FUNCTION: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.	MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.; MISCELLANEOUS: [Isoform 2]: =Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: =Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: =Produced by alternative splicing of isoform 1. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Produced by alternative promoter usage. {ECO:0000269|PubMed:20554076}.	positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cell migration [GO:0030335]; regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000298]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018]	14-3-3 protein binding [GO:0071889]; actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; filamin binding [GO:0031005]; muscle alpha-actinin binding [GO:0051371]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018]; 14-3-3 protein binding [GO:0071889]; actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; filamin binding [GO:0031005]; muscle alpha-actinin binding [GO:0051371]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cell migration [GO:0030335]; regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000298]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91YE8}. Cytoplasm {ECO:0000250|UniProtKB:Q91YE8}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24005909}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:20554076}. Cell junction, focal adhesion {ECO:0000269|PubMed:20554076}. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. In undifferentiated myoblasts strongly expressed in the nucleus, after induction of myotube differentiation is located to both nucleus and cytoplasm along acting filaments, and in differentiated myotubes is located at the Z lines. Upon stress redistributes from cytoplasm of myoblasts and myotubes to the nucleus. Nuclear import is KPNA2-dependent and promoted by phosphorylation by PKA and/or CaMK2, and inhibition of calcineurin. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern, partly overlapping with filamentous actin (PubMed:18371299). {ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:18371299}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24005909}. Note=Localizes to induced actin bundles with contiguous staining. {ECO:0000269|PubMed:24005909}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24005909}. Note=Localizes to induced actin bundles with punctuate staining. {ECO:0000269|PubMed:24005909}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24005909}. Note=Localizes to induced irregular actin bundles with contiguous and punctuated staining. {ECO:0000269|PubMed:24005909}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24005909}. Note=Localizes to induced actin bundles with punctuate staining. {ECO:0000269|PubMed:24005909}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24005909}. Note=Localizes to induced actin bundles with contiguous staining. {ECO:0000269|PubMed:24005909}.
Q9UMW8	reviewed	UBP18_HUMAN	Ubl carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (43 kDa ISG15-specific protease) (hUBP43) (ISG15-specific-processing protease) (Ubl thioesterase 18)	USP18 ISG43	Homo sapiens (Human)	372	FUNCTION: Interferon-induced ISG15-specific protease that plays a crucial role for maintaining a proper balance of ISG15-conjugated proteins in cells (PubMed:11788588). Regulates protein ISGylation by efficiently cleaving ISG15 conjugates linked via isopeptide bonds. Regulates T-cell activation and T-helper 17 (Th17) cell differentiation by deubiquitinating TAK1, likely to keep TAK1-TAB complexes in steady conditions (PubMed:23825189). In turn, restricts activation of NF-kappa-B, NFAT, and JNK as well as expression of IL2 in T-cells after TCR activation (PubMed:23825189). Acts as a molecular adapter with USP20 to promote innate antiviral response through deubiquitinating STING1 (PubMed:27801882). Involved also in the negative regulation of the inflammatory response triggered by type I interferon (PubMed:28165510, PubMed:27325888). Upon recruitment by STAT2 to the type I interferon receptor subunit IFNAR2 interferes with the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and acts as a negative regulator of the type I interferon signaling pathway (PubMed:28165510). {ECO:0000269|PubMed:11788588, ECO:0000269|PubMed:23825189, ECO:0000269|PubMed:27325888, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:28165510}.; FUNCTION: [Isoform 2]: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins (PubMed:22170061). {ECO:0000269|PubMed:22170061}.	MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at a CTG start codon. An IRES Element in the 5' region contributes to expression. {ECO:0000305}.	antiviral innate immune response [GO:0140374]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; proteolysis [GO:0006508]; regulation of inflammatory response [GO:0050727]; response to bacterium [GO:0009617]; response to stilbenoid [GO:0035634]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; ISG15-specific peptidase activity [GO:0019785]; molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; ISG15-specific peptidase activity [GO:0019785]; molecular adaptor activity [GO:0060090]; antiviral innate immune response [GO:0140374]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; proteolysis [GO:0006508]; regulation of inflammatory response [GO:0050727]; response to bacterium [GO:0009617]; response to stilbenoid [GO:0035634]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:22170061}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:22170061}. Cytoplasm {ECO:0000269|PubMed:22170061}.
Q9UMX0	reviewed	UBQL1_HUMAN	Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)	UBQLN1 DA41 PLIC1	Homo sapiens (Human)	589	FUNCTION: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (PubMed:22233804). {ECO:0000250|UniProtKB:Q9JJP9, ECO:0000269|PubMed:18307982, ECO:0000269|PubMed:19148225, ECO:0000269|PubMed:19822669, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:21695056, ECO:0000269|PubMed:22233804, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:23459205, ECO:0000303|PubMed:15147878}.; FUNCTION: [Isoform 1]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269|PubMed:18953672, ECO:0000269|PubMed:21143716}.; FUNCTION: [Isoform 2]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress. {ECO:0000269|PubMed:18953672}.; FUNCTION: [Isoform 3]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269|PubMed:18953672, ECO:0000269|PubMed:21143716}.	MISCELLANEOUS: May be a prognostic marker for lung adenocarcinoma patient clinical outcome. {ECO:0000269|PubMed:22233804}.	aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; cellular response to hypoxia [GO:0071456]; macroautophagy [GO:0016236]; negative regulation of store-operated calcium channel activity [GO:1901340]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of protein ubiquitination [GO:0031398]; regulation of macroautophagy [GO:0016241]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; regulation of protein ubiquitination [GO:0031396]; response to endoplasmic reticulum stress [GO:0034976]; ubiquitin-dependent ERAD pathway [GO:0030433]	aggresome [GO:0016235]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; kinase binding [GO:0019900]; polyubiquitin modification-dependent protein binding [GO:0031593]	aggresome [GO:0016235]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; polyubiquitin modification-dependent protein binding [GO:0031593]; aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; cellular response to hypoxia [GO:0071456]; macroautophagy [GO:0016236]; negative regulation of store-operated calcium channel activity [GO:1901340]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of protein ubiquitination [GO:0031398]; regulation of macroautophagy [GO:0016241]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; regulation of protein ubiquitination [GO:0031396]; response to endoplasmic reticulum stress [GO:0034976]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16159959, ECO:0000269|PubMed:23979357}. Nucleus {ECO:0000269|PubMed:23979357}. Endoplasmic reticulum {ECO:0000269|PubMed:19822669}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:19148225, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:21143716, ECO:0000269|PubMed:21695056, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:23459205}. Cell membrane {ECO:0000269|PubMed:21143716, ECO:0000269|PubMed:23307288}. Note=Detected in neuronal processes and at synapses (By similarity). Recruited to the ER during ER-associated protein degradation (ERAD) (PubMed:19822669). Isoform 1 and isoform 3 colocalize with PSEN1 in the cell membrane and in cytoplasmic juxtanuclear structures called aggresomes (PubMed:21143716). Colocalizes with ORAI1 and TICAM1 in the autophagosome (PubMed:23307288, PubMed:21695056). Colocalizes with EPS15 and HGS in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and with EPS15 also in aggresomes (PubMed:16159959). {ECO:0000250|UniProtKB:Q9JJP9, ECO:0000269|PubMed:16159959, ECO:0000269|PubMed:19822669, ECO:0000269|PubMed:21143716, ECO:0000269|PubMed:21695056, ECO:0000269|PubMed:23307288}.
Q9UMX1	reviewed	SUFU_HUMAN	Suppressor of fused homolog (SUFUH)	SUFU UNQ650/PRO1280	Homo sapiens (Human)	484	FUNCTION: Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:12068298, PubMed:12975309, PubMed:27234298, PubMed:15367681, PubMed:22365972, PubMed:24217340, PubMed:24311597, PubMed:28965847). Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24217340, PubMed:24311597). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24311597, PubMed:24217340). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling (By similarity). Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL) (PubMed:24311597, PubMed:28965847). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state (PubMed:24311597, PubMed:28965847). Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R (PubMed:24311597, PubMed:28965847). When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A) (PubMed:24311597, PubMed:28965847). Required for normal embryonic development (By similarity). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z0P7, ECO:0000269|PubMed:10559945, ECO:0000269|PubMed:10564661, ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:12068298, ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:15367681, ECO:0000269|PubMed:22365972, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:27234298, ECO:0000269|PubMed:28965847}.	MISCELLANEOUS: [Isoform 1]: Major isoform.	aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; heart looping [GO:0001947]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural tube closure [GO:0001843]; positive regulation of cellular response to drug [GO:2001040]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; skin development [GO:0043588]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; spermatid development [GO:0007286]; ventricular septum development [GO:0003281]	ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	beta-catenin binding [GO:0008013]; protein kinase binding [GO:0019901]; transcription corepressor activity [GO:0003714]	ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; beta-catenin binding [GO:0008013]; protein kinase binding [GO:0019901]; transcription corepressor activity [GO:0003714]; aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; heart looping [GO:0001947]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural tube closure [GO:0001843]; positive regulation of cellular response to drug [GO:2001040]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; skin development [GO:0043588]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; spermatid development [GO:0007286]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10559945, ECO:0000269|PubMed:28965847}. Nucleus {ECO:0000269|PubMed:10559945, ECO:0000269|PubMed:28965847}.
Q9UMX2	reviewed	OAZ3_HUMAN	Ornithine decarboxylase antizyme 3 (AZ3) (ODC-Az 3)	OAZ3	Homo sapiens (Human)	235	FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity). {ECO:0000250|UniProtKB:Q9R109, ECO:0000269|PubMed:17900240}.		negative regulation of polyamine transmembrane transport [GO:1902268]; polyamine biosynthetic process [GO:0006596]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein catabolic process [GO:0045732]; spermatogenesis [GO:0007283]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ornithine decarboxylase inhibitor activity [GO:0008073]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ornithine decarboxylase inhibitor activity [GO:0008073]; negative regulation of polyamine transmembrane transport [GO:1902268]; polyamine biosynthetic process [GO:0006596]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein catabolic process [GO:0045732]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}.
Q9UMX3	reviewed	BOK_HUMAN	Bcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9)	BOK BCL2L9	Homo sapiens (Human)	212	FUNCTION: [Isoform 1]: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155). {ECO:0000250|UniProtKB:O35425, ECO:0000269|PubMed:15102863, ECO:0000269|PubMed:19942931, ECO:0000269|PubMed:20673843, ECO:0000269|PubMed:24113155, ECO:0000269|PubMed:27076518}.; FUNCTION: [Isoform 2]: Pro-apoptotic molecule exerting its function through the mitochondrial pathway. {ECO:0000269|PubMed:15775999}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; male gonad development [GO:0008584]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of necroptotic process [GO:0060546]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; oligodendrocyte differentiation [GO:0048709]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; protein complex oligomerization [GO:0051259]; regulation of autophagy [GO:0010506]; regulation of chorionic trophoblast cell proliferation [GO:1901382]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of granulosa cell apoptotic process [GO:1904708]; release of cytochrome c from mitochondria [GO:0001836]	cis-Golgi network membrane [GO:0033106]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear outer membrane [GO:0005640]; nucleus [GO:0005634]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]	BH domain binding [GO:0051400]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]	cis-Golgi network membrane [GO:0033106]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear outer membrane [GO:0005640]; nucleus [GO:0005634]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]; BH domain binding [GO:0051400]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; male gonad development [GO:0008584]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of necroptotic process [GO:0060546]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; oligodendrocyte differentiation [GO:0048709]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; protein complex oligomerization [GO:0051259]; regulation of autophagy [GO:0010506]; regulation of chorionic trophoblast cell proliferation [GO:1901382]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of granulosa cell apoptotic process [GO:1904708]; release of cytochrome c from mitochondria [GO:0001836]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion membrane {ECO:0000250|UniProtKB:O35425}; Single-pass membrane protein {ECO:0000250|UniProtKB:O35425}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27076518}; Single-pass membrane protein {ECO:0000250|UniProtKB:O35425}. Mitochondrion inner membrane {ECO:0000269|PubMed:24113155}. Cytoplasm {ECO:0000269|PubMed:15868100, ECO:0000269|PubMed:16302269, ECO:0000269|PubMed:19942931, ECO:0000269|PubMed:20673843, ECO:0000269|PubMed:24113155}. Nucleus {ECO:0000269|PubMed:16302269, ECO:0000269|PubMed:19942931, ECO:0000269|PubMed:20673843}. Mitochondrion {ECO:0000269|PubMed:15102863, ECO:0000269|PubMed:15868100, ECO:0000269|PubMed:19942931, ECO:0000269|PubMed:27076518}. Endoplasmic reticulum {ECO:0000269|PubMed:16302269}. Mitochondrion outer membrane {ECO:0000269|PubMed:27076518}. Early endosome membrane {ECO:0000250|UniProtKB:O35425}. Recycling endosome membrane {ECO:0000250|UniProtKB:O35425}. Nucleus outer membrane {ECO:0000250|UniProtKB:O35425}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:O35425}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:O35425}. Membrane {ECO:0000269|PubMed:19942931}. Note=Nuclear and cytoplasmic compartments in the early stages of apoptosis and during apoptosis it associates with mitochondria (PubMed:19942931). In healthy cells, associates loosely with the membrane in a hit-and-run mode. The insertion and accumulation on membranes is enhanced through the activity of death signals, resulting in the integration of the membrane-bound protein into the membrane (PubMed:15868100). The transmembrane domain controls subcellular localization; constitutes a tail-anchor. Localizes in early and late endosome upon blocking of apoptosis. Must localize to the mitochondria to induce mitochondrial outer membrane permeabilization and apoptosis (By similarity). {ECO:0000250|UniProtKB:O35425, ECO:0000269|PubMed:15868100, ECO:0000269|PubMed:19942931}.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane {ECO:0000269|PubMed:19942931}. Cytoplasm {ECO:0000269|PubMed:19942931}.
Q9UMX5	reviewed	NENF_HUMAN	Neudesin (Cell immortalization-related protein 2) (Neuron-derived neurotrophic factor) (Protein GIG47) (Secreted protein of unknown function) (SPUF protein)	NENF CIR2 SPUF	Homo sapiens (Human)	172	FUNCTION: Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (PubMed:31536960). Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). {ECO:0000250|UniProtKB:Q9CQ45, ECO:0000269|PubMed:31536960}.	MISCELLANEOUS: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). {ECO:0000303|PubMed:23763432, ECO:0000303|PubMed:28396637}.	MAPK cascade [GO:0000165]; negative regulation of appetite [GO:0032099]; positive regulation of MAPK cascade [GO:0043410]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739]	growth factor activity [GO:0008083]; metal ion binding [GO:0046872]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739]; growth factor activity [GO:0008083]; metal ion binding [GO:0046872]; MAPK cascade [GO:0000165]; negative regulation of appetite [GO:0032099]; positive regulation of MAPK cascade [GO:0043410]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:31536960}. Mitochondrion {ECO:0000269|PubMed:31536960}. Endoplasmic reticulum {ECO:0000269|PubMed:31536960}. Note=Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7. {ECO:0000269|PubMed:31536960}.
Q9UMX6	reviewed	GUC1B_HUMAN	Guanylyl cyclase-activating protein 2 (GCAP 2) (Guanylate cyclase activator 1B)	GUCA1B GCAP2	Homo sapiens (Human)	200	FUNCTION: Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). {ECO:0000250|UniProtKB:P51177, ECO:0000250|UniProtKB:Q8VBV8}.	MISCELLANEOUS: Binds three calcium ions. {ECO:0000250}.	body fluid secretion [GO:0007589]; cell-cell signaling [GO:0007267]; receptor guanylyl cyclase signaling pathway [GO:0007168]; visual perception [GO:0007601]	cone photoreceptor outer segment [GO:0120199]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]	cone photoreceptor outer segment [GO:0120199]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]; body fluid secretion [GO:0007589]; cell-cell signaling [GO:0007267]; receptor guanylyl cyclase signaling pathway [GO:0007168]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51177}; Lipid-anchor {ECO:0000250|UniProtKB:P51177}. Photoreceptor inner segment {ECO:0000269|PubMed:9620085}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:9620085}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000250|UniProtKB:Q8VBV8}.
Q9UMX9	reviewed	S45A2_HUMAN	Membrane-associated transporter protein (Melanoma antigen AIM1) (Protein AIM-1) (Solute carrier family 45 member 2)	SLC45A2 AIM1 MATP	Homo sapiens (Human)	530	FUNCTION: Proton-associated glucose and sucrose transporter (By similarity). May be able to transport also fructose (By similarity). Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis (PubMed:32966160, PubMed:35469906). Regulates melanogenesis by maintaining melanosome neutralization that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR (PubMed:32966160, PubMed:35469906). {ECO:0000250|UniProtKB:P58355, ECO:0000269|PubMed:18563784, ECO:0000269|PubMed:18683857, ECO:0000269|PubMed:32966160, ECO:0000269|PubMed:35469906}.		developmental pigmentation [GO:0048066]; lysosomal lumen pH elevation [GO:0035752]; melanin biosynthetic process from tyrosine [GO:0006583]; response to stimulus [GO:0050896]; sucrose transport [GO:0015770]; visual perception [GO:0007601]	melanosome membrane [GO:0033162]; membrane [GO:0016020]	glucose:proton symporter activity [GO:0005356]; sucrose:proton symporter activity [GO:0008506]	melanosome membrane [GO:0033162]; membrane [GO:0016020]; glucose:proton symporter activity [GO:0005356]; sucrose:proton symporter activity [GO:0008506]; developmental pigmentation [GO:0048066]; lysosomal lumen pH elevation [GO:0035752]; melanin biosynthetic process from tyrosine [GO:0006583]; response to stimulus [GO:0050896]; sucrose transport [GO:0015770]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:32966160}; Multi-pass membrane protein {ECO:0000269|PubMed:17081065}. Note=Enriched in mature melanocyte membrane subdomains. {ECO:0000269|PubMed:32966160}.
Q9UMY1	reviewed	NOL7_HUMAN	Nucleolar protein 7 (Nucleolar protein of 27 kDa)	NOL7 C6orf90 NOP27	Homo sapiens (Human)	257	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}.		ribosomal small subunit biogenesis [GO:0042274]	chromosome [GO:0005694]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	chromosome [GO:0005694]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16205646, ECO:0000269|PubMed:34516797}.
Q9UMY4	reviewed	SNX12_HUMAN	Sorting nexin-12	SNX12	Homo sapiens (Human)	162	FUNCTION: May be involved in several stages of intracellular trafficking. {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	endocytic recycling [GO:0032456]; late endosome to Golgi transport [GO:0034499]; negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of protein transport [GO:0051224]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; retromer complex [GO:0030904]	enzyme binding [GO:0019899]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; retromer complex [GO:0030904]; enzyme binding [GO:0019899]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]; endocytic recycling [GO:0032456]; late endosome to Golgi transport [GO:0034499]; negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of protein transport [GO:0051224]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q9UMZ2	reviewed	SYNRG_HUMAN	Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin)	SYNRG AP1GBP1 SYNG	Homo sapiens (Human)	1314	FUNCTION: Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}.		endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]	AP-1 adaptor complex [GO:0030121]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]		AP-1 adaptor complex [GO:0030121]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9JKC9}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9JKC9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JKC9}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15758025}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:15758025}. Note=Localization at clathrin-coated vesicles depends on AFTPH/aftiphilin (PubMed:15758025). Associates with membranes via the adapter protein complex AP-1 (By similarity). Colocalizes with AP1G1 (By similarity). {ECO:0000250|UniProtKB:Q9JKC9, ECO:0000269|PubMed:15758025}.
Q9UMZ3	reviewed	PTPRQ_HUMAN	Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48)	PTPRQ	Homo sapiens (Human)	2332	FUNCTION: Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells. {ECO:0000269|PubMed:19351528}.		dephosphorylation [GO:0016311]; regulation of fat cell differentiation [GO:0045598]	membrane [GO:0016020]; receptor complex [GO:0043235]	protein tyrosine phosphatase activity [GO:0004725]	membrane [GO:0016020]; receptor complex [GO:0043235]; protein tyrosine phosphatase activity [GO:0004725]; dephosphorylation [GO:0016311]; regulation of fat cell differentiation [GO:0045598]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12837292}; Single-pass type I membrane protein {ECO:0000269|PubMed:12837292}.
Q9UN19	reviewed	DAPP1_HUMAN	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa)	DAPP1 BAM32 HSPC066	Homo sapiens (Human)	280	FUNCTION: May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269|PubMed:10770799}.		protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phospholipid binding [GO:0005543]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10770799}. Membrane {ECO:0000269|PubMed:10770799}; Peripheral membrane protein {ECO:0000269|PubMed:10770799}. Note=Membrane-associated after cell stimulation leading to its translocation.
Q9UN36	reviewed	NDRG2_HUMAN	Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Syld709613)	NDRG2 KIAA1248 SYLD	Homo sapiens (Human)	371	FUNCTION: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:16103061, ECO:0000269|PubMed:21247902}.		cell differentiation [GO:0030154]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; regulation of platelet-derived growth factor production [GO:0090361]; regulation of vascular endothelial growth factor production [GO:0010574]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762]; vascular associated smooth muscle cell proliferation [GO:1990874]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; cell differentiation [GO:0030154]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; regulation of platelet-derived growth factor production [GO:0090361]; regulation of vascular endothelial growth factor production [GO:0010574]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762]; vascular associated smooth muscle cell proliferation [GO:1990874]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.
Q9UN37	reviewed	VPS4A_HUMAN	Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4)	VPS4A VPS4	Homo sapiens (Human)	437	FUNCTION: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization, chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase (PubMed:33186545). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Critical for normal erythroblast cytokinesis and correct erythropoiesis (PubMed:33186543). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:15075231, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:33186543, ECO:0000269|PubMed:33186545}.; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:11595185}.		abscission [GO:0009838]; actomyosin contractile ring contraction [GO:0000916]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; cytoskeleton-dependent cytokinesis [GO:0061640]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; ESCRT complex disassembly [GO:1904896]; ESCRT III complex disassembly [GO:1904903]; intracellular cholesterol transport [GO:0032367]; late endosomal microautophagy [GO:0061738]; late endosome to lysosome transport via multivesicular body sorting pathway [GO:0061764]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic nuclear membrane reassembly [GO:0007084]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; negative regulation of cytokinesis [GO:0032466]; nuclear envelope organization [GO:0006998]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein targeting to lysosome [GO:0006622]; regulation of protein localization [GO:0032880]; regulation of protein localization to plasma membrane [GO:1903076]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuole organization [GO:0007033]; vesicle budding from membrane [GO:0006900]; vesicle uncoating [GO:0072319]; vesicle-mediated transport [GO:0016192]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076]	ATPase complex [GO:1904949]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; midbody [GO:0030496]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]; vacuolar membrane [GO:0005774]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; protein-containing complex binding [GO:0044877]	ATPase complex [GO:1904949]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; midbody [GO:0030496]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]; vacuolar membrane [GO:0005774]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; protein-containing complex binding [GO:0044877]; abscission [GO:0009838]; actomyosin contractile ring contraction [GO:0000916]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; cytoskeleton-dependent cytokinesis [GO:0061640]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; ESCRT complex disassembly [GO:1904896]; ESCRT III complex disassembly [GO:1904903]; intracellular cholesterol transport [GO:0032367]; late endosomal microautophagy [GO:0061738]; late endosome to lysosome transport via multivesicular body sorting pathway [GO:0061764]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic nuclear membrane reassembly [GO:0007084]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; negative regulation of cytokinesis [GO:0032466]; nuclear envelope organization [GO:0006998]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein targeting to lysosome [GO:0006622]; regulation of protein localization [GO:0032880]; regulation of protein localization to plasma membrane [GO:1903076]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuole organization [GO:0007033]; vesicle budding from membrane [GO:0006900]; vesicle uncoating [GO:0072319]; vesicle-mediated transport [GO:0016192]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q8VEJ9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VEJ9}. Midbody {ECO:0000269|PubMed:24814515}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:33186543}. Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells, interaction with ZFYVE19/ANCHR mediates retention at midbody (PubMed:24814515). Localized in two distinct rings on either side of the Flemming body. {ECO:0000269|PubMed:24814515}.
Q9UN42	reviewed	AT1B4_HUMAN	Protein ATP1B4 (X,K-ATPase subunit beta-m) (X/potassium-transporting ATPase subunit beta-m)	ATP1B4	Homo sapiens (Human)	357	FUNCTION: May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit. {ECO:0000269|PubMed:17592128}.		potassium ion transport [GO:0006813]; regulation of DNA-templated transcription [GO:0006355]; sodium ion transport [GO:0006814]	nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]	inorganic cation transmembrane transporter activity [GO:0022890]	nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; inorganic cation transmembrane transporter activity [GO:0022890]; potassium ion transport [GO:0006813]; regulation of DNA-templated transcription [GO:0006355]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Detected in nuclear envelops. {ECO:0000269|PubMed:14656723, ECO:0000269|PubMed:17592128}.
Q9UN72	reviewed	PCDA7_HUMAN	Protocadherin alpha-7 (PCDH-alpha-7)	PCDHA7 CNRS4	Homo sapiens (Human)	937	FUNCTION: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain. {ECO:0000250|UniProtKB:Q91Y13}.		cell adhesion [GO:0007155]; cell-cell recognition [GO:0009988]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; cell adhesion [GO:0007155]; cell-cell recognition [GO:0009988]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q91Y13}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q91Y13}.
Q9UN73	reviewed	PCDA6_HUMAN	Protocadherin alpha-6 (PCDH-alpha-6)	PCDHA6 CNRS2	Homo sapiens (Human)	950	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q9UN74	reviewed	PCDA4_HUMAN	Protocadherin alpha-4 (PCDH-alpha-4)	PCDHA4	Homo sapiens (Human)	947	FUNCTION: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain. {ECO:0000250|UniProtKB:O88689}.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O88689}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O88689}. Note=Detected in dendrites and synapses. {ECO:0000250|UniProtKB:O88689}.
Q9UN76	reviewed	S6A14_HUMAN	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14)	SLC6A14	Homo sapiens (Human)	642	FUNCTION: Amino acid transporter that plays an important role in the absorption of amino acids in the intestinal tract. Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner (PubMed:10446133). Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). Can also transport carnitine, butirylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:17855766). {ECO:0000250|UniProtKB:Q9JMA9, ECO:0000269|PubMed:10446133, ECO:0000269|PubMed:17855766, ECO:0000269|PubMed:18599538}.	MISCELLANEOUS: Transport inhibited by BCH (2-aminobicyclo-[2.2.1]-heptane-2-carboxylic acid).	(R)-carnitine transmembrane transport [GO:1902270]; alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; beta-alanine transport [GO:0001762]; response to toxic substance [GO:0009636]; sodium ion transmembrane transport [GO:0035725]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	(R)-carnitine transmembrane transporter activity [GO:1901235]; alanine transmembrane transporter activity [GO:0022858]; amino acid transmembrane transporter activity [GO:0015171]; aromatic amino acid transmembrane transporter activity [GO:0015173]; beta-alanine transmembrane transporter activity [GO:0001761]; branched-chain amino acid:sodium symporter activity [GO:0015657]; L-proline transmembrane transporter activity [GO:0015193]; neutral, basic amino acid:sodium:chloride symporter activity [GO:0015374]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; (R)-carnitine transmembrane transporter activity [GO:1901235]; alanine transmembrane transporter activity [GO:0022858]; amino acid transmembrane transporter activity [GO:0015171]; aromatic amino acid transmembrane transporter activity [GO:0015173]; beta-alanine transmembrane transporter activity [GO:0001761]; branched-chain amino acid:sodium symporter activity [GO:0015657]; L-proline transmembrane transporter activity [GO:0015193]; neutral, basic amino acid:sodium:chloride symporter activity [GO:0015374]; (R)-carnitine transmembrane transport [GO:1902270]; alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; beta-alanine transport [GO:0001762]; response to toxic substance [GO:0009636]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:10446133}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9JMA9}; Multi-pass membrane protein {ECO:0000255}.
Q9UN79	reviewed	SOX13_HUMAN	Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12)	SOX13	Homo sapiens (Human)	622	FUNCTION: Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}.		anatomical structure morphogenesis [GO:0009653]; cell fate commitment [GO:0045165]; gamma-delta T cell differentiation [GO:0042492]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord oligodendrocyte cell differentiation [GO:0021529]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; cell fate commitment [GO:0045165]; gamma-delta T cell differentiation [GO:0042492]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord oligodendrocyte cell differentiation [GO:0021529]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Cytoplasm {ECO:0000269|PubMed:10871192}.
Q9UN81	reviewed	LORF1_HUMAN	LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1)	L1RE1 LRE1	Homo sapiens (Human)	338	FUNCTION: Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. {ECO:0000269|PubMed:11158327, ECO:0000269|PubMed:21937507, ECO:0000269|PubMed:28806172, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:8945518}.	MISCELLANEOUS: Long interspersed element-1/LINE-1/L1 retrotransposons are present in more than 500'000 full (6 kb) or truncated copies in the human genome. Most of them are inactive but 80 to 100 of those elements could be transcribed, translated and active in any individual. An active LINE-1 encodes for 2 proteins translated from a single RNA containing 2 non-overlapping ORFs, ORF1 and ORF2. ORF1p is described in this entry as a representative of all ORF1p potentially expressed by active elements. ORF2p is described in the related entry AC O00370.	retrotransposition [GO:0032197]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; nucleolus [GO:0005730]; ribonucleoprotein complex [GO:1990904]	identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; nucleolus [GO:0005730]; ribonucleoprotein complex [GO:1990904]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; retrotransposition [GO:0032197]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:17562864}. Cytoplasm {ECO:0000269|PubMed:27428332}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:16183655, ECO:0000269|PubMed:30122351}. Cytoplasm, Stress granule {ECO:0000269|PubMed:17562864, ECO:0000269|PubMed:23093941}. Note=Colocalizes with its encoding RNA in cytoplasmic ribonucleoprotein particle (PubMed:16183655). Mainly cytoplasmic, rarely detected in the nucleus, possibly within the nucleolus (PubMed:17562864). {ECO:0000269|PubMed:16183655, ECO:0000269|PubMed:17562864}.
Q9UN86	reviewed	G3BP2_HUMAN	Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)	G3BP2 KIAA0660	Homo sapiens (Human)	482	FUNCTION: Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granule formation (PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:32302570, PubMed:32302571, PubMed:32302572). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). {ECO:0000250|UniProtKB:Q13283, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572}.		cytoplasmic sequestering of NF-kappaB [GO:0007253]; innate immune response [GO:0045087]; mRNA transport [GO:0051028]; positive regulation of stress granule assembly [GO:0062029]; protein homooligomerization [GO:0051260]; Ras protein signal transduction [GO:0007265]; stress granule assembly [GO:0034063]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]	molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling receptor complex adaptor activity [GO:0030159]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling receptor complex adaptor activity [GO:0030159]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; innate immune response [GO:0045087]; mRNA transport [GO:0051028]; positive regulation of stress granule assembly [GO:0062029]; protein homooligomerization [GO:0051260]; Ras protein signal transduction [GO:0007265]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:30404792}. Cytoplasm, Stress granule {ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30404792}.
Q9UN88	reviewed	GBRT_HUMAN	Gamma-aminobutyric acid receptor subunit theta (GABA(A) receptor subunit theta)	GABRQ	Homo sapiens (Human)	632	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.		chloride transmembrane transport [GO:1902476]; signal transduction [GO:0007165]	chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; receptor complex [GO:0043235]; synapse [GO:0045202]	chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594]; neurotransmitter transmembrane transporter activity [GO:0005326]; transmembrane signaling receptor activity [GO:0004888]	chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; receptor complex [GO:0043235]; synapse [GO:0045202]; chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594]; neurotransmitter transmembrane transporter activity [GO:0005326]; transmembrane signaling receptor activity [GO:0004888]; chloride transmembrane transport [GO:1902476]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Q9UNA0	reviewed	ATS5_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2)	ADAMTS5 ADAMTS11 ADMP2	Homo sapiens (Human)	930	FUNCTION: Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection. {ECO:0000250|UniProtKB:Q9R001, ECO:0000269|PubMed:16133547, ECO:0000269|PubMed:18992360}.		aortic valve morphogenesis [GO:0003180]; defense response to bacterium [GO:0042742]; endocardial cushion morphogenesis [GO:0003203]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; myoblast fusion [GO:0007520]; negative regulation of cold-induced thermogenesis [GO:0120163]; proteolysis [GO:0006508]; pulmonary valve morphogenesis [GO:0003184]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	endopeptidase activity [GO:0004175]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; endopeptidase activity [GO:0004175]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270]; aortic valve morphogenesis [GO:0003180]; defense response to bacterium [GO:0042742]; endocardial cushion morphogenesis [GO:0003203]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; myoblast fusion [GO:0007520]; negative regulation of cold-induced thermogenesis [GO:0120163]; proteolysis [GO:0006508]; pulmonary valve morphogenesis [GO:0003184]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18992360}.
Q9UNA1	reviewed	RHG26_HUMAN	Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26)	ARHGAP26 GRAF KIAA0621 OPHN1L	Homo sapiens (Human)	814	FUNCTION: GTPase-activating protein for RHOA and CDC42.		actin cytoskeleton organization [GO:0030036]; nervous system development [GO:0007399]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]	GTPase activator activity [GO:0005096]; phospholipid binding [GO:0005543]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; GTPase activator activity [GO:0005096]; phospholipid binding [GO:0005543]; actin cytoskeleton organization [GO:0030036]; nervous system development [GO:0007399]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with actin stress fibers and cortical actin structures. {ECO:0000250}.
Q9UNA3	reviewed	A4GCT_HUMAN	Alpha-1,4-N-acetylglucosaminyltransferase (Alpha4GnT) (EC 2.4.1.-)	A4GNT	Homo sapiens (Human)	340	FUNCTION: Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity). {ECO:0000250|UniProtKB:Q14BT6, ECO:0000269|PubMed:10430883}.		carbohydrate metabolic process [GO:0005975]; epithelial cell proliferation [GO:0050673]; glycoprotein biosynthetic process [GO:0009101]; negative regulation of epithelial cell proliferation [GO:0050680]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	acetylglucosaminyltransferase activity [GO:0008375]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; acetylglucosaminyltransferase activity [GO:0008375]; carbohydrate metabolic process [GO:0005975]; epithelial cell proliferation [GO:0050673]; glycoprotein biosynthetic process [GO:0009101]; negative regulation of epithelial cell proliferation [GO:0050680]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000255}.
Q9UNA4	reviewed	POLI_HUMAN	DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B)	POLI RAD30B	Homo sapiens (Human)	740	FUNCTION: Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunoglobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940). {ECO:0000269|PubMed:11013228, ECO:0000269|PubMed:11251121, ECO:0000269|PubMed:11387224, ECO:0000269|PubMed:12410315, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15199127, ECO:0000269|PubMed:15254543}.		DNA repair [GO:0006281]; DNA replication [GO:0006260]; error-prone translesion synthesis [GO:0042276]; translesion synthesis [GO:0019985]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; error-prone translesion synthesis [GO:0042276]; translesion synthesis [GO:0019985]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12606586}. Note=Binding to ubiquitin mediates localization to replication forks after UV-induced DNA damage. {ECO:0000250|UniProtKB:Q6R3M4}.
Q9UNE0	reviewed	EDAR_HUMAN	Tumor necrosis factor receptor superfamily member EDAR (Anhidrotic ectodysplasin receptor 1) (Downless homolog) (EDA-A1 receptor) (Ectodermal dysplasia receptor) (Ectodysplasin-A receptor)	EDAR DL	Homo sapiens (Human)	448	FUNCTION: Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.		apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; epidermis development [GO:0008544]; hair follicle development [GO:0001942]; odontogenesis of dentin-containing tooth [GO:0042475]; pigmentation [GO:0043473]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; salivary gland cavitation [GO:0060662]	apical part of cell [GO:0045177]; membrane [GO:0016020]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	apical part of cell [GO:0045177]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; epidermis development [GO:0008544]; hair follicle development [GO:0001942]; odontogenesis of dentin-containing tooth [GO:0042475]; pigmentation [GO:0043473]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; salivary gland cavitation [GO:0060662]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9UNE2	reviewed	RPH3L_HUMAN	Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein)	RPH3AL NOC2	Homo sapiens (Human)	315	FUNCTION: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15003533}.		exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; intracellular protein transport [GO:0006886]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of insulin secretion [GO:0032024]; regulation of calcium ion-dependent exocytosis [GO:0017158]; spontaneous neurotransmitter secretion [GO:0061669]	cytoplasm [GO:0005737]; presynapse [GO:0098793]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658]	cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; presynapse [GO:0098793]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658]; cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; intracellular protein transport [GO:0006886]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of insulin secretion [GO:0032024]; regulation of calcium ion-dependent exocytosis [GO:0017158]; spontaneous neurotransmitter secretion [GO:0061669]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15003533}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:15003533}. Note=Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells.
Q9UNE7	reviewed	CHIP_HUMAN	E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)	STUB1 CHIP PP1131	Homo sapiens (Human)	303	FUNCTION: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (PubMed:15466472). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (PubMed:10330192, PubMed:11146632, PubMed:15466472). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (PubMed:11557750, PubMed:23990462). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (PubMed:19713937). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (PubMed:28813410). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609). {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11146632, ECO:0000269|PubMed:11557750, ECO:0000269|PubMed:15466472, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19567782, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24043303, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:29883609}.	MISCELLANEOUS: Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in colorectal cancer patients.	cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; cellular response to misfolded protein [GO:0071218]; chaperone-mediated autophagy [GO:0061684]; DNA repair [GO:0006281]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERBB2 signaling pathway [GO:0038128]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of chaperone-mediated protein complex assembly [GO:0090035]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of proteolysis [GO:0045862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein maturation [GO:0051604]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of glucocorticoid metabolic process [GO:0031943]; regulation of protein stability [GO:0031647]; response to ischemia [GO:0002931]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151]; Z disc [GO:0030018]	enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; kinase binding [GO:0019900]; misfolded protein binding [GO:0051787]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; R-SMAD binding [GO:0070412]; SMAD binding [GO:0046332]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151]; Z disc [GO:0030018]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; kinase binding [GO:0019900]; misfolded protein binding [GO:0051787]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; R-SMAD binding [GO:0070412]; SMAD binding [GO:0046332]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]; cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; cellular response to misfolded protein [GO:0071218]; chaperone-mediated autophagy [GO:0061684]; DNA repair [GO:0006281]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERBB2 signaling pathway [GO:0038128]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of chaperone-mediated protein complex assembly [GO:0090035]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of proteolysis [GO:0045862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein maturation [GO:0051604]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of glucocorticoid metabolic process [GO:0031943]; regulation of protein stability [GO:0031647]; response to ischemia [GO:0002931]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:23973223}. Nucleus {ECO:0000269|PubMed:23973223}. Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg). {ECO:0000269|PubMed:23973223}.
Q9UNF0	reviewed	PACN2_HUMAN	Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)	PACSIN2	Homo sapiens (Human)	486	FUNCTION: Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}.		actin cytoskeleton organization [GO:0030036]; caveola assembly [GO:0070836]; caveolin-mediated endocytosis [GO:0072584]; cell projection morphogenesis [GO:0048858]; cytoskeleton organization [GO:0007010]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of endocytosis [GO:0045806]; plasma membrane tubulation [GO:0097320]; protein localization to endosome [GO:0036010]; regulation of endocytosis [GO:0030100]	caveola [GO:0005901]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; ruffle membrane [GO:0032587]	cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phosphatidic acid binding [GO:0070300]; phospholipid binding [GO:0005543]	caveola [GO:0005901]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; ruffle membrane [GO:0032587]; cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phosphatidic acid binding [GO:0070300]; phospholipid binding [GO:0005543]; actin cytoskeleton organization [GO:0030036]; caveola assembly [GO:0070836]; caveolin-mediated endocytosis [GO:0072584]; cell projection morphogenesis [GO:0048858]; cytoskeleton organization [GO:0007010]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of endocytosis [GO:0045806]; plasma membrane tubulation [GO:0097320]; protein localization to endosome [GO:0036010]; regulation of endocytosis [GO:0030100]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection {ECO:0000269|PubMed:31242077}. Membrane, caveola {ECO:0000269|PubMed:22323287}. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
Q9UNF1	reviewed	MAGD2_HUMAN	Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen)	MAGED2 BCG1	Homo sapiens (Human)	606	FUNCTION: Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}.		female pregnancy [GO:0007565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; renal sodium ion absorption [GO:0070294]	cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]		cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; female pregnancy [GO:0007565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; renal sodium ion absorption [GO:0070294]	
Q9UNG2	reviewed	TNF18_HUMAN	Tumor necrosis factor ligand superfamily member 18 (Activation-inducible TNF-related ligand) (AITRL) (Glucocorticoid-induced TNF-related ligand) (hGITRL)	TNFSF18 AITRL GITRL TL6 UNQ149/PRO175	Homo sapiens (Human)	177	FUNCTION: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TS55, ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044, ECO:0000269|PubMed:23892569}.		adaptive immune response [GO:0002250]; cell-cell signaling [GO:0007267]; negative regulation of apoptotic process [GO:0043066]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; positive regulation of cell adhesion [GO:0045785]; positive regulation of inflammatory response [GO:0050729]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of dendritic cell chemotaxis [GO:2000508]; regulation of protein-containing complex assembly [GO:0043254]; regulation of T cell proliferation [GO:0042129]; signal transduction [GO:0007165]; T cell proliferation involved in immune response [GO:0002309]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor superfamily binding [GO:0032813]	cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor superfamily binding [GO:0032813]; adaptive immune response [GO:0002250]; cell-cell signaling [GO:0007267]; negative regulation of apoptotic process [GO:0043066]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; positive regulation of cell adhesion [GO:0045785]; positive regulation of inflammatory response [GO:0050729]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of dendritic cell chemotaxis [GO:2000508]; regulation of protein-containing complex assembly [GO:0043254]; regulation of T cell proliferation [GO:0042129]; signal transduction [GO:0007165]; T cell proliferation involved in immune response [GO:0002309]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17449724}; Single-pass type II membrane protein {ECO:0000269|PubMed:17449724}.
Q9UNH5	reviewed	CC14A_HUMAN	Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A)	CDC14A	Homo sapiens (Human)	594	FUNCTION: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cilium assembly [GO:0060271]; dephosphorylation [GO:0016311]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of cytokinesis [GO:0032467]; regulation of exit from mitosis [GO:0007096]; sensory perception of sound [GO:0007605]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinociliary basal body [GO:1902636]; kinocilium [GO:0060091]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]; stereocilium tip [GO:0032426]	myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinociliary basal body [GO:1902636]; kinocilium [GO:0060091]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]; stereocilium tip [GO:0032426]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cell cycle [GO:0007049]; cell division [GO:0051301]; cilium assembly [GO:0060271]; dephosphorylation [GO:0016311]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of cytokinesis [GO:0032467]; regulation of exit from mitosis [GO:0007096]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9367992}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:15263015}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15263015}. Cell projection, kinocilium {ECO:0000250|UniProtKB:Q6GQT0}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q6GQT0}. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (PubMed:12134069, PubMed:11901424, PubMed:15263015). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (By similarity). {ECO:0000250|UniProtKB:Q6GQT0, ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:15263015}.
Q9UNH6	reviewed	SNX7_HUMAN	Sorting nexin-7	SNX7	Homo sapiens (Human)	387	FUNCTION: Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:32513819). Together with SNX4, involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819). {ECO:0000269|PubMed:32513819}.		autophagy of mitochondrion [GO:0000422]; endocytic recycling [GO:0032456]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; protein transport [GO:0015031]; reticulophagy [GO:0061709]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; phagophore assembly site [GO:0000407]	phosphatidylinositol binding [GO:0035091]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; phagophore assembly site [GO:0000407]; phosphatidylinositol binding [GO:0035091]; autophagy of mitochondrion [GO:0000422]; endocytic recycling [GO:0032456]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; protein transport [GO:0015031]; reticulophagy [GO:0061709]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:32513819}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95219}; Cytoplasmic side {ECO:0000250|UniProtKB:O95219}.
Q9UNH7	reviewed	SNX6_HUMAN	Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed]	SNX6	Homo sapiens (Human)	406	FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). {ECO:0000250|UniProtKB:Q6P8X1, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774, ECO:0000269|PubMed:20354142, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:19935774, ECO:0000303|PubMed:20830743, ECO:0000305}.		cellular response to amyloid-beta [GO:1904646]; cellular response to epidermal growth factor stimulus [GO:0071364]; intracellular protein transport [GO:0006886]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of macroautophagy [GO:0016241]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; retrograde transport, endosome to Golgi [GO:0042147]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; lysosome [GO:0005764]; nucleus [GO:0005634]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; tubular endosome [GO:0097422]	dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; type I transforming growth factor beta receptor binding [GO:0034713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; lysosome [GO:0005764]; nucleus [GO:0005634]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; tubular endosome [GO:0097422]; dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; type I transforming growth factor beta receptor binding [GO:0034713]; cellular response to amyloid-beta [GO:1904646]; cellular response to epidermal growth factor stimulus [GO:0071364]; intracellular protein transport [GO:0006886]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of macroautophagy [GO:0016241]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:11485546, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774}. Early endosome membrane {ECO:0000269|PubMed:19935774, ECO:0000303|PubMed:11485546}; Peripheral membrane protein {ECO:0000269|PubMed:11485546}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:20354142}. Cytoplasm {ECO:0000269|PubMed:20830743}. Nucleus {ECO:0000269|PubMed:11591366, ECO:0000269|PubMed:20830743}. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus. {ECO:0000269|PubMed:19935774}.
Q9UNI1	reviewed	CELA1_HUMAN	Chymotrypsin-like elastase family member 1 (EC 3.4.21.36) (Elastase-1) (Pancreatic elastase 1)	CELA1 ELA1	Homo sapiens (Human)	258	FUNCTION: Serine proteases that hydrolyze many proteins in addition to elastin. {ECO:0000250|UniProtKB:Q91X79}.		elastin catabolic process [GO:0060309]; exocrine pancreas development [GO:0031017]; inflammatory response [GO:0006954]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pancreas morphogenesis [GO:0061113]; positive regulation of angiogenesis [GO:0045766]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; proteolysis [GO:0006508]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; tissue remodeling [GO:0048771]; transcription by RNA polymerase II [GO:0006366]; Wnt signaling pathway [GO:0016055]	extracellular space [GO:0005615]	metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]	extracellular space [GO:0005615]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; elastin catabolic process [GO:0060309]; exocrine pancreas development [GO:0031017]; inflammatory response [GO:0006954]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pancreas morphogenesis [GO:0061113]; positive regulation of angiogenesis [GO:0045766]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; proteolysis [GO:0006508]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; tissue remodeling [GO:0048771]; transcription by RNA polymerase II [GO:0006366]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P00772}.
Q9UNI6	reviewed	DUS12_HUMAN	Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1)	DUSP12	Homo sapiens (Human)	340	FUNCTION: Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). {ECO:0000250|UniProtKB:Q9JIM4, ECO:0000269|PubMed:10446167, ECO:0000269|PubMed:24531476}.		dephosphorylation [GO:0016311]; protein modification process [GO:0036211]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	kinase binding [GO:0019900]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; kinase binding [GO:0019900]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; zinc ion binding [GO:0008270]; dephosphorylation [GO:0016311]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10446167}. Cytoplasm, cytosol {ECO:0000269|PubMed:10446167}. Note=Primarily nuclear. Detected in a mesh-like pattern in the cytosol. {ECO:0000269|PubMed:10446167}.
Q9UNK0	reviewed	STX8_HUMAN	Syntaxin-8	STX8	Homo sapiens (Human)	236	FUNCTION: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.		cellular response to type II interferon [GO:0071346]; early endosome to late endosome transport [GO:0045022]; intracellular protein transport [GO:0006886]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982]	chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982]; chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; ubiquitin protein ligase binding [GO:0031625]; cellular response to type II interferon [GO:0071346]; early endosome to late endosome transport [GO:0045022]; intracellular protein transport [GO:0006886]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity). {ECO:0000250}.
Q9UNK4	reviewed	PA2GD_HUMAN	Group IID secretory phospholipase A2 (GIID sPLA2) (sPLA2-IID) (EC 3.1.1.4) (PLA2IID) (Phosphatidylcholine 2-acylhydrolase 2D) (Secretory-type PLA, stroma-associated homolog)	PLA2G2D SPLASH	Homo sapiens (Human)	145	FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed:10681567). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10455175). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (By similarity). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (By similarity). May act in an autocrine and paracrine manner (By similarity). Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (By similarity). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity). {ECO:0000250|UniProtKB:Q9WVF6, ECO:0000269|PubMed:10455175, ECO:0000269|PubMed:10681567}.		arachidonic acid secretion [GO:0050482]; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; inflammatory response [GO:0006954]; lipid catabolic process [GO:0016042]; negative regulation of T cell proliferation [GO:0042130]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644]; regulation of acute inflammatory response to antigenic stimulus [GO:0002864]	extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543]	extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543]; arachidonic acid secretion [GO:0050482]; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; inflammatory response [GO:0006954]; lipid catabolic process [GO:0016042]; negative regulation of T cell proliferation [GO:0042130]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644]; regulation of acute inflammatory response to antigenic stimulus [GO:0002864]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10455175}.
Q9UNL4	reviewed	ING4_HUMAN	Inhibitor of growth protein 4 (p29ING4)	ING4 My036	Homo sapiens (Human)	249	FUNCTION: Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). {ECO:0000250|UniProtKB:Q8C0D7, ECO:0000269|PubMed:15029197, ECO:0000269|PubMed:15251430, ECO:0000269|PubMed:15528276, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:16387653}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Lacks the nuclear localization signal (NLS), resulting in increased cytoplasmic localization. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Lacks the nuclear localization signal (NLS), resulting in increased cytoplasmic localization. {ECO:0000305}.; MISCELLANEOUS: [Isoform 7]: Lacks the nuclear localization signal (NLS), resulting in increased cytoplasmic localization. {ECO:0000305}.	apoptotic process [GO:0006915]; cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; DNA replication-dependent chromatin disassembly [GO:0140889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of growth [GO:0045926]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; protein acetylation [GO:0006473]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; transcription coactivator activity [GO:0003713]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; DNA replication-dependent chromatin disassembly [GO:0140889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of growth [GO:0045926]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; protein acetylation [GO:0006473]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15029197, ECO:0000269|PubMed:16973615}.
Q9UNM6	reviewed	PSD13_HUMAN	26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5)	PSMD13	Homo sapiens (Human)	376	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.		meiosis I [GO:0007127]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]; structural molecule activity [GO:0005198]; meiosis I [GO:0007127]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q9UNN5	reviewed	FAF1_HUMAN	FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A)	FAF1 UBXD12 UBXN3A CGI-03	Homo sapiens (Human)	650	FUNCTION: Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:P54731, ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}.		apoptotic process [GO:0006915]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA replication [GO:0045740]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein-containing complex assembly [GO:0031334]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent ERAD pathway [GO:0030433]	CD95 death-inducing signaling complex [GO:0031265]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ooplasm [GO:1990917]; perinuclear region of cytoplasm [GO:0048471]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	heat shock protein binding [GO:0031072]; NF-kappaB binding [GO:0051059]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]	CD95 death-inducing signaling complex [GO:0031265]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ooplasm [GO:1990917]; perinuclear region of cytoplasm [GO:0048471]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; heat shock protein binding [GO:0031072]; NF-kappaB binding [GO:0051059]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA replication [GO:0045740]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein-containing complex assembly [GO:0031334]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26842564}.
Q9UNN8	reviewed	EPCR_HUMAN	Endothelial protein C receptor (Activated protein C receptor) (APC receptor) (Endothelial cell protein C receptor) (CD antigen CD201)	PROCR EPCR	Homo sapiens (Human)	238	FUNCTION: Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.		blood coagulation [GO:0007596]; negative regulation of coagulation [GO:0050819]	cell surface [GO:0009986]; centrosome [GO:0005813]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; centrosome [GO:0005813]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; blood coagulation [GO:0007596]; negative regulation of coagulation [GO:0050819]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9UNP4	reviewed	SIAT9_HUMAN	Lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.3.9) (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase) (GM3 synthase) (Ganglioside GM3 synthase) (ST3Gal V) (ST3GalV) (Sialyltransferase 9)	ST3GAL5 SIAT9 UNQ2510/PRO5998	Homo sapiens (Human)	418	FUNCTION: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis) (PubMed:9822625, PubMed:16934889). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer) (PubMed:16934889). {ECO:0000269|PubMed:16934889, ECO:0000269|PubMed:9822625}.		ganglioside biosynthetic process [GO:0001574]; glycosphingolipid biosynthetic process [GO:0006688]; protein glycosylation [GO:0006486]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; lactosylceramide alpha-2,3-sialyltransferase activity [GO:0047291]; sialyltransferase activity [GO:0008373]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; lactosylceramide alpha-2,3-sialyltransferase activity [GO:0047291]; sialyltransferase activity [GO:0008373]; ganglioside biosynthetic process [GO:0001574]; glycosphingolipid biosynthetic process [GO:0006688]; protein glycosylation [GO:0006486]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9UNP9	reviewed	PPIE_HUMAN	Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)	PPIE CYP33	Homo sapiens (Human)	301	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:8977107, PubMed:18258190, PubMed:20677832, PubMed:20460131). Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:8977107, PubMed:18258190, PubMed:20460131). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:8977107, PubMed:18258190, PubMed:20677832, PubMed:20541251). Inhibits KMT2A activity; this requires proline isomerase activity (PubMed:20677832, PubMed:20541251, PubMed:20460131). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:18258190, ECO:0000269|PubMed:20460131, ECO:0000269|PubMed:20541251, ECO:0000269|PubMed:20677832, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:8977107}.		mRNA splicing, via spliceosome [GO:0000398]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of DNA-templated transcription [GO:0006355]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; U2-type catalytic step 2 spliceosome [GO:0071007]	cyclosporin A binding [GO:0016018]; mRNA binding [GO:0003729]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; U2-type catalytic step 2 spliceosome [GO:0071007]; cyclosporin A binding [GO:0016018]; mRNA binding [GO:0003729]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:8977107}.
Q9UNQ0	reviewed	ABCG2_HUMAN	Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338)	ABCG2 ABCP BCRP BCRP1 MXR	Homo sapiens (Human)	655	FUNCTION: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562, PubMed:36749388). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). {ECO:0000250|UniProtKB:Q7TMS5, ECO:0000269|PubMed:11306452, ECO:0000269|PubMed:12477054, ECO:0000269|PubMed:12682043, ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:15670731, ECO:0000269|PubMed:18056989, ECO:0000269|PubMed:19506252, ECO:0000269|PubMed:20110355, ECO:0000269|PubMed:20368174, ECO:0000269|PubMed:20705604, ECO:0000269|PubMed:22132962, ECO:0000269|PubMed:23189181, ECO:0000269|PubMed:28554189, ECO:0000269|PubMed:30405239, ECO:0000269|PubMed:31003562, ECO:0000269|PubMed:31254042, ECO:0000305|PubMed:12958161}.		biotin transport [GO:0015878]; cellular detoxification [GO:1990748]; export across plasma membrane [GO:0140115]; lipid transport [GO:0006869]; organic anion transport [GO:0015711]; renal urate salt excretion [GO:0097744]; riboflavin transport [GO:0032218]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; urate metabolic process [GO:0046415]; xenobiotic transport across blood-brain barrier [GO:1990962]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; external side of apical plasma membrane [GO:0098591]; membrane raft [GO:0045121]; mitochondrial membrane [GO:0031966]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; biotin transmembrane transporter activity [GO:0015225]; efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802]; organic anion transmembrane transporter activity [GO:0008514]; protein homodimerization activity [GO:0042803]; riboflavin transmembrane transporter activity [GO:0032217]; urate transmembrane transporter activity [GO:0015143]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; external side of apical plasma membrane [GO:0098591]; membrane raft [GO:0045121]; mitochondrial membrane [GO:0031966]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; biotin transmembrane transporter activity [GO:0015225]; efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802]; organic anion transmembrane transporter activity [GO:0008514]; protein homodimerization activity [GO:0042803]; riboflavin transmembrane transporter activity [GO:0032217]; urate transmembrane transporter activity [GO:0015143]; xenobiotic transmembrane transporter activity [GO:0042910]; biotin transport [GO:0015878]; cellular detoxification [GO:1990748]; export across plasma membrane [GO:0140115]; lipid transport [GO:0006869]; organic anion transport [GO:0015711]; renal urate salt excretion [GO:0097744]; riboflavin transport [GO:0032218]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; urate metabolic process [GO:0046415]; xenobiotic transport across blood-brain barrier [GO:1990962]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15001581, ECO:0000269|PubMed:15769853, ECO:0000269|PubMed:15807535, ECO:0000269|PubMed:18056989, ECO:0000269|PubMed:31003562, ECO:0000269|PubMed:31254042}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19506252}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:23189181}; Multi-pass membrane protein {ECO:0000255}. Note=Enriched in membrane lipid rafts. {ECO:0000269|PubMed:28623970}.
Q9UNQ2	reviewed	DIM1_HUMAN	Probable dimethyladenosine transferase (EC 2.1.1.183) (DIM1 dimethyladenosine transferase 1 homolog) (DIM1 dimethyladenosine transferase 1-like) (Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase) (Probable 18S rRNA dimethylase) (Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase)	DIMT1 DIMT1L HUSSY-05	Homo sapiens (Human)	313	FUNCTION: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:25851604, ECO:0000269|PubMed:34516797}.		positive regulation of rRNA processing [GO:2000234]; ribosomal small subunit biogenesis [GO:0042274]; rRNA methylation [GO:0031167]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity [GO:0052909]; RNA binding [GO:0003723]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity [GO:0052909]; RNA binding [GO:0003723]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]; positive regulation of rRNA processing [GO:2000234]; ribosomal small subunit biogenesis [GO:0042274]; rRNA methylation [GO:0031167]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:25851604}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:25851604, ECO:0000269|PubMed:34516797}.
Q9UNS1	reviewed	TIM_HUMAN	Protein timeless homolog (hTIM)	TIMELESS TIM TIM1 TIMELESS1	Homo sapiens (Human)	1208	FUNCTION: Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:9856465, PubMed:17141802, PubMed:17296725, PubMed:23418588, PubMed:26344098, PubMed:23359676, PubMed:35585232, PubMed:31138685, PubMed:32705708). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:9856465, PubMed:31138685). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}.		branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to hydroxyurea [GO:0072711]; circadian rhythm [GO:0007623]; detection of abiotic stimulus [GO:0009582]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; lung development [GO:0030324]; morphogenesis of an epithelium [GO:0002009]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of circadian rhythm [GO:0042752]; replication fork arrest [GO:0043111]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork protection complex [GO:0031298]; site of double-strand break [GO:0035861]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork protection complex [GO:0031298]; site of double-strand break [GO:0035861]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to hydroxyurea [GO:0072711]; circadian rhythm [GO:0007623]; detection of abiotic stimulus [GO:0009582]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; lung development [GO:0030324]; morphogenesis of an epithelium [GO:0002009]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of circadian rhythm [GO:0042752]; replication fork arrest [GO:0043111]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:31138685}. Chromosome {ECO:0000269|PubMed:26344098}. Note=In response to double-strand breaks (DSBs), accumulates at DNA damage sites via its interaction with PARP1. {ECO:0000269|PubMed:26344098}.
Q9UNS2	reviewed	CSN3_HUMAN	COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)	COPS3 CSN3	Homo sapiens (Human)	423	FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.	MISCELLANEOUS: Amplified and overexpressed in some osteosarcomas (OS), suggesting that it may participate in TP53 degradation in OS.	in utero embryonic development [GO:0001701]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902162]; regulation of protein neddylation [GO:2000434]; response to light stimulus [GO:0009416]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]		COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; in utero embryonic development [GO:0001701]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902162]; regulation of protein neddylation [GO:2000434]; response to light stimulus [GO:0009416]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Q9UNT1	reviewed	RBL2B_HUMAN	Rab-like protein 2B	RABL2B	Homo sapiens (Human)	228	FUNCTION: Small GTPase required for ciliation. Activated in a guanine nucleotide exchange factor (GEF)-independent manner via its intrinsic GDP for GTP nucleotide exchange ability (PubMed:28625565). Involved in ciliary assembly by binding the intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28625565, PubMed:28428259). {ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565}.		cilium assembly [GO:0060271]; intracellular protein transport [GO:0006886]; intraciliary transport [GO:0042073]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; pericentriolar material [GO:0000242]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; pericentriolar material [GO:0000242]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cilium assembly [GO:0060271]; intracellular protein transport [GO:0006886]; intraciliary transport [GO:0042073]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28428259}. Cytoplasm {ECO:0000269|PubMed:28625565}. Note=Localizes on the mother centriole. Localizes slightly apical to the subdistal appendage, but below the distal appendage. {ECO:0000269|PubMed:28625565}.
Q9UNU6	reviewed	CP8B1_HUMAN	7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (EC 1.14.14.139) (7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase) (CYPVIIIB1) (Cytochrome P450 8B1) (Sterol 12-alpha-hydroxylase)	CYP8B1 CYP12	Homo sapiens (Human)	501	FUNCTION: A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis. Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis (PubMed:10051404). Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase) (By similarity). {ECO:0000250|UniProtKB:O02766, ECO:0000250|UniProtKB:O88962, ECO:0000269|PubMed:10051404}.		bile acid biosynthetic process [GO:0006699]; bile acid signaling pathway [GO:0038183]; positive regulation of intestinal cholesterol absorption [GO:0045797]; response to cholesterol [GO:0070723]; response to nutrient levels [GO:0031667]; sterol metabolic process [GO:0016125]	endoplasmic reticulum membrane [GO:0005789]	5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity [GO:0033779]; 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity [GO:0033778]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxygen binding [GO:0019825]; sterol 12-alpha-hydroxylase activity [GO:0008397]	endoplasmic reticulum membrane [GO:0005789]; 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity [GO:0033779]; 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity [GO:0033778]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxygen binding [GO:0019825]; sterol 12-alpha-hydroxylase activity [GO:0008397]; bile acid biosynthetic process [GO:0006699]; bile acid signaling pathway [GO:0038183]; positive regulation of intestinal cholesterol absorption [GO:0045797]; response to cholesterol [GO:0070723]; response to nutrient levels [GO:0031667]; sterol metabolic process [GO:0016125]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O02766}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:O02766}; Single-pass membrane protein {ECO:0000255}.
Q9UNW1	reviewed	MINP1_HUMAN	Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase)	MINPP1 MIPP UNQ900/PRO1917	Homo sapiens (Human)	487	FUNCTION: Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (PubMed:33257696). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity). Through the regulation of intracellular inositol polyphosphates, may control intracellular cation homeostasis, including that of calcium and iron, hence affecting free cation availability required for neural cell signaling (PubMed:33257696). {ECO:0000250|UniProtKB:F1NPQ2, ECO:0000269|PubMed:18413611, ECO:0000269|PubMed:33257696}.		bone mineralization [GO:0030282]; inositol phosphate metabolic process [GO:0043647]; ossification [GO:0001503]; polyphosphate metabolic process [GO:0006797]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]	acid phosphatase activity [GO:0003993]; bisphosphoglycerate 3-phosphatase activity [GO:0034417]; inositol hexakisphosphate 2-phosphatase activity [GO:0052826]; inositol phosphate phosphatase activity [GO:0052745]; inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity [GO:0030351]; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [GO:0051717]; protein histidine phosphatase activity [GO:0101006]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; acid phosphatase activity [GO:0003993]; bisphosphoglycerate 3-phosphatase activity [GO:0034417]; inositol hexakisphosphate 2-phosphatase activity [GO:0052826]; inositol phosphate phosphatase activity [GO:0052745]; inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity [GO:0030351]; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [GO:0051717]; protein histidine phosphatase activity [GO:0101006]; bone mineralization [GO:0030282]; inositol phosphate metabolic process [GO:0043647]; ossification [GO:0001503]; polyphosphate metabolic process [GO:0006797]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:O35217}.
Q9UNW8	reviewed	GP132_HUMAN	Probable G-protein coupled receptor 132 (G2 accumulation protein)	GPR132 G2A	Homo sapiens (Human)	380	FUNCTION: May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity. {ECO:0000269|PubMed:12586833, ECO:0000269|PubMed:19855098, ECO:0000269|PubMed:9770487}.	MISCELLANEOUS: [Isoform 3]: More abundant than isoform 1 in leukocytes by approximately 3-fold. {ECO:0000305}.	G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity). {ECO:0000250}.
Q9UNW9	reviewed	NOVA2_HUMAN	RNA-binding protein Nova-2 (Astrocytic NOVA1-like RNA-binding protein) (Neuro-oncological ventral antigen 2)	NOVA2 ANOVA NOVA3	Homo sapiens (Human)	492	FUNCTION: Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion (PubMed:32197073). It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons (PubMed:10811881). Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Uniquely regulates alternative splicing events of a series of axon guidance related genes during cortical development, being essential for central nervous system development by regulating neural networks wiring. Regulates differentially alternative splicing on the same transcripts expressed in different neurons. This includes functional differences in transcripts expressed in cortical and cerebellar excitatory versus inhibitory neurons where is required for, respectively, development of laminar structure and motor coordination and synapse formation. Also the regulation the regulation of intron retention can sequester the trans-acting splicing factor PTBP2, acting as a variable cis-acting scaffolding platform for PTBP2 across various natural conditions (By similarity). {ECO:0000250|UniProtKB:A0A1W2P872, ECO:0000269|PubMed:10811881, ECO:0000269|PubMed:32197073}.		central nervous system neuron development [GO:0021954]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cold-induced thermogenesis [GO:0120163]; neuron differentiation [GO:0030182]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of axon guidance [GO:1902667]; regulation of RNA metabolic process [GO:0051252]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; central nervous system neuron development [GO:0021954]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cold-induced thermogenesis [GO:0120163]; neuron differentiation [GO:0030182]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of axon guidance [GO:1902667]; regulation of RNA metabolic process [GO:0051252]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A0A1W2P872}.
Q9UNX4	reviewed	WDR3_HUMAN	WD repeat-containing protein 3	WDR3	Homo sapiens (Human)	943	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}.		maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]	nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]; snoRNA binding [GO:0030515]	nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:34516797}.
Q9UNY4	reviewed	TTF2_HUMAN	Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2)	TTF2	Homo sapiens (Human)	1162	FUNCTION: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}.		DNA repair [GO:0006281]; DNA-templated transcription termination [GO:0006353]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]	cytosol [GO:0005829]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; transcription elongation factor complex [GO:0008023]	ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; transcription elongation factor complex [GO:0008023]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270]; DNA repair [GO:0006281]; DNA-templated transcription termination [GO:0006353]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15125840}. Nucleus {ECO:0000269|PubMed:15125840}. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.
Q9UNY5	reviewed	ZN232_HUMAN	Zinc finger protein 232 (Zinc finger and SCAN domain-containing protein 11)	ZNF232 ZSCAN11	Homo sapiens (Human)	417	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q9UNZ2	reviewed	NSF1C_HUMAN	NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47)	NSFL1C UBXN2C	Homo sapiens (Human)	370	FUNCTION: Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}.		autophagosome assembly [GO:0000045]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of protein localization to centrosome [GO:1904780]; nuclear membrane reassembly [GO:0031468]; positive regulation of mitotic centrosome separation [GO:0046604]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi stack [GO:0005795]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; VCP-NSFL1C complex [GO:1990730]	lipid binding [GO:0008289]; ubiquitin binding [GO:0043130]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi stack [GO:0005795]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; VCP-NSFL1C complex [GO:1990730]; lipid binding [GO:0008289]; ubiquitin binding [GO:0043130]; autophagosome assembly [GO:0000045]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of protein localization to centrosome [GO:1904780]; nuclear membrane reassembly [GO:0031468]; positive regulation of mitotic centrosome separation [GO:0046604]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O35987}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:O35987}. Chromosome {ECO:0000250|UniProtKB:O35987}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O35987}. Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase. {ECO:0000250|UniProtKB:O35987}.
Q9UP38	reviewed	FZD1_HUMAN	Frizzled-1 (Fz-1) (hFz1) (FzE1)	FZD1	Homo sapiens (Human)	647	FUNCTION: Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). {ECO:0000250|UniProtKB:O70421, ECO:0000269|PubMed:10557084, ECO:0000305}.; FUNCTION: (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. {ECO:0000269|PubMed:27680706}.		astrocyte-dopaminergic neuron signaling [GO:0036520]; autocrine signaling [GO:0035425]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [GO:0044338]; canonical Wnt signaling pathway involved in osteoblast differentiation [GO:0044339]; cell-cell signaling [GO:0007267]; endothelial cell differentiation [GO:0045446]; hard palate development [GO:0060022]; membranous septum morphogenesis [GO:0003149]; muscular septum morphogenesis [GO:0003150]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein phosphorylation [GO:0001934]; presynapse assembly [GO:0099054]; regulation of presynapse assembly [GO:1905606]; response to xenobiotic stimulus [GO:0009410]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]	cell surface [GO:0009986]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909]	frizzled binding [GO:0005109]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909]; frizzled binding [GO:0005109]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; astrocyte-dopaminergic neuron signaling [GO:0036520]; autocrine signaling [GO:0035425]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [GO:0044338]; canonical Wnt signaling pathway involved in osteoblast differentiation [GO:0044339]; cell-cell signaling [GO:0007267]; endothelial cell differentiation [GO:0045446]; hard palate development [GO:0060022]; membranous septum morphogenesis [GO:0003149]; muscular septum morphogenesis [GO:0003150]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein phosphorylation [GO:0001934]; presynapse assembly [GO:0099054]; regulation of presynapse assembly [GO:1905606]; response to xenobiotic stimulus [GO:0009410]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10557084}; Multi-pass membrane protein {ECO:0000255}.
Q9UP52	reviewed	TFR2_HUMAN	Transferrin receptor protein 2 (TfR2)	TFR2	Homo sapiens (Human)	801	FUNCTION: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.	MISCELLANEOUS: The variant Lys-172 found in hereditary hemochromatosis type III affects the putative initiation codon of the beta isoform thus preventing its translation.	acute-phase response [GO:0006953]; cellular response to iron ion [GO:0071281]; endocytic iron import into cell [GO:0140298]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; positive regulation of endocytosis [GO:0045807]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein maturation [GO:1903319]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor-mediated endocytosis [GO:0006898]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to iron ion [GO:0010039]; transferrin transport [GO:0033572]	cytoplasmic vesicle [GO:0031410]; external side of plasma membrane [GO:0009897]; HFE-transferrin receptor complex [GO:1990712]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	co-receptor binding [GO:0039706]; transferrin receptor activity [GO:0004998]	cytoplasmic vesicle [GO:0031410]; external side of plasma membrane [GO:0009897]; HFE-transferrin receptor complex [GO:1990712]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; co-receptor binding [GO:0039706]; transferrin receptor activity [GO:0004998]; acute-phase response [GO:0006953]; cellular response to iron ion [GO:0071281]; endocytic iron import into cell [GO:0140298]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; positive regulation of endocytosis [GO:0045807]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein maturation [GO:1903319]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor-mediated endocytosis [GO:0006898]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to iron ion [GO:0010039]; transferrin transport [GO:0033572]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Isoform Beta]: Cytoplasm {ECO:0000305}. Note=Lacks the transmembrane domain. Probably intracellular.
Q9UP65	reviewed	PA24C_HUMAN	Cytosolic phospholipase A2 gamma (cPLA2-gamma) (EC 3.1.1.4) (Cytosolic lysophospholipase) (EC 3.1.1.5) (Cytosolic lysophospholipid O-acyltransferase) (EC 2.3.1.-) (Phospholipase A2 group IVC)	PLA2G4C	Homo sapiens (Human)	541	FUNCTION: Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis (PubMed:19501189, PubMed:9705332, PubMed:10085124, PubMed:10358058, PubMed:28336330). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:19501189, PubMed:9705332, PubMed:10085124, PubMed:10358058, PubMed:28336330). Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids (PubMed:19501189, PubMed:15944408). Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency (PubMed:19501189, PubMed:15944408). In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles (PubMed:28336330). {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189, ECO:0000269|PubMed:28336330, ECO:0000269|PubMed:9705332}.; FUNCTION: (Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV) (PubMed:23015700, PubMed:28336330). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur (PubMed:23015700). Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly (PubMed:23015700, PubMed:28336330). {ECO:0000269|PubMed:23015700, ECO:0000269|PubMed:28336330}.; FUNCTION: (Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission. {ECO:0000269|PubMed:28639618}.		arachidonic acid metabolic process [GO:0019369]; glycerophospholipid catabolic process [GO:0046475]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; lipid droplet formation [GO:0140042]; parturition [GO:0007567]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phospholipid metabolic process [GO:0006644]; platelet activating factor biosynthetic process [GO:0006663]	cell cortex [GO:0005938]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; O-acyltransferase activity [GO:0008374]; phosphatidyl phospholipase B activity [GO:0102545]; phospholipase A1 activity [GO:0008970]; phospholipid binding [GO:0005543]	cell cortex [GO:0005938]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; O-acyltransferase activity [GO:0008374]; phosphatidyl phospholipase B activity [GO:0102545]; phospholipase A1 activity [GO:0008970]; phospholipid binding [GO:0005543]; arachidonic acid metabolic process [GO:0019369]; glycerophospholipid catabolic process [GO:0046475]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; lipid droplet formation [GO:0140042]; parturition [GO:0007567]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phospholipid metabolic process [GO:0006644]; platelet activating factor biosynthetic process [GO:0006663]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:14529291, ECO:0000269|PubMed:9705332}; Lipid-anchor {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:14529291, ECO:0000269|PubMed:9705332}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189, ECO:0000269|PubMed:28336330}; Lipid-anchor. Mitochondrion membrane {ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189}; Lipid-anchor. Lipid droplet {ECO:0000269|PubMed:28336330}. Note=Translocates from endoplasmic reticulum to lipid droplets in response to oleate. {ECO:0000269|PubMed:28336330}.
Q9UP79	reviewed	ATS8_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (EC 3.4.24.-) (METH-2) (METH-8)	ADAMTS8 METH2	Homo sapiens (Human)	889	FUNCTION: Has anti-angiogenic properties.		extracellular matrix organization [GO:0030198]; negative regulation of cell population proliferation [GO:0008285]; proteolysis [GO:0006508]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	heparin binding [GO:0008201]; integrin binding [GO:0005178]; low-affinity phosphate transmembrane transporter activity [GO:0009673]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; low-affinity phosphate transmembrane transporter activity [GO:0009673]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; extracellular matrix organization [GO:0030198]; negative regulation of cell population proliferation [GO:0008285]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q9UP83	reviewed	COG5_HUMAN	Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1)	COG5 GOLTC1 GTC90	Homo sapiens (Human)	839	FUNCTION: Required for normal Golgi function. {ECO:0000250}.		glycosylation [GO:0070085]; Golgi organization [GO:0007030]; inter-Golgi cisterna vesicle-mediated transport [GO:0048219]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; trans-Golgi network membrane [GO:0032588]		cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; trans-Golgi network membrane [GO:0032588]; glycosylation [GO:0070085]; Golgi organization [GO:0007030]; inter-Golgi cisterna vesicle-mediated transport [GO:0048219]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:9792665}. Golgi apparatus membrane {ECO:0000269|PubMed:9792665}; Peripheral membrane protein {ECO:0000269|PubMed:9792665}.
Q9UP95	reviewed	S12A4_HUMAN	Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1)	SLC12A4 KCC1	Homo sapiens (Human)	1085	FUNCTION: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}.		ammonium import across plasma membrane [GO:0140157]; cell volume homeostasis [GO:0006884]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]	lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	ammonium transmembrane transporter activity [GO:0008519]; ATP binding [GO:0005524]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901]	lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; ammonium transmembrane transporter activity [GO:0008519]; ATP binding [GO:0005524]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901]; ammonium import across plasma membrane [GO:0140157]; cell volume homeostasis [GO:0006884]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:10913127}; Multi-pass membrane protein {ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912}.
Q9UPA5	reviewed	BSN_HUMAN	Protein bassoon (Zinc finger protein 231)	BSN KIAA0434 ZNF231	Homo sapiens (Human)	3926	FUNCTION: Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). {ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}.		chemical synaptic transmission [GO:0007268]; presynapse to nucleus signaling pathway [GO:0099526]; presynaptic active zone assembly [GO:1904071]; protein localization to synapse [GO:0035418]; regulation of synaptic vesicle cycle [GO:0098693]; synaptic vesicle clustering [GO:0097091]	axon [GO:0030424]; cell surface [GO:0009986]; cochlear hair cell ribbon synapse [GO:0098683]; cytoskeleton of presynaptic active zone [GO:0048788]; dendrite [GO:0030425]; excitatory synapse [GO:0060076]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuron projection terminus [GO:0044306]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	metal ion binding [GO:0046872]; structural constituent of presynaptic active zone [GO:0098882]	axon [GO:0030424]; cell surface [GO:0009986]; cochlear hair cell ribbon synapse [GO:0098683]; cytoskeleton of presynaptic active zone [GO:0048788]; dendrite [GO:0030425]; excitatory synapse [GO:0060076]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuron projection terminus [GO:0044306]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; metal ion binding [GO:0046872]; structural constituent of presynaptic active zone [GO:0098882]; chemical synaptic transmission [GO:0007268]; presynapse to nucleus signaling pathway [GO:0099526]; presynaptic active zone assembly [GO:1904071]; protein localization to synapse [GO:0035418]; regulation of synaptic vesicle cycle [GO:0098693]; synaptic vesicle clustering [GO:0097091]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O88778}. Presynaptic active zone {ECO:0000250|UniProtKB:O88778}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O88778}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O88778}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88778}. Note=In retina, is localized in the outer plexiform layer at ribbon synapses formed by rods and cones but was absent from basal synaptic contacts formed by cones. In the retinal inner plexiform layer localized to conventional inhibitory GABAergic synapses, made by amacrine cells, but absent from the bipolar cell ribbon synapses. {ECO:0000250|UniProtKB:O88778}.
Q9UPE1	reviewed	SRPK3_HUMAN	SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23)	SRPK3 MSSK1 STK23	Homo sapiens (Human)	567	FUNCTION: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; intracellular signal transduction [GO:0035556]; muscle tissue development [GO:0060537]; phosphorylation [GO:0016310]; regulation of mRNA processing [GO:0050684]; skeletal muscle tissue development [GO:0007519]; spliceosomal complex assembly [GO:0000245]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cell differentiation [GO:0030154]; intracellular signal transduction [GO:0035556]; muscle tissue development [GO:0060537]; phosphorylation [GO:0016310]; regulation of mRNA processing [GO:0050684]; skeletal muscle tissue development [GO:0007519]; spliceosomal complex assembly [GO:0000245]	
Q9UPG8	reviewed	PLAL2_HUMAN	Zinc finger protein PLAGL2 (Pleiomorphic adenoma-like protein 2)	PLAGL2 KIAA0198	Homo sapiens (Human)	496	FUNCTION: Shows weak transcriptional activatory activity.		chylomicron assembly [GO:0034378]; lipid metabolic process [GO:0006629]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; chylomicron assembly [GO:0034378]; lipid metabolic process [GO:0006629]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UPI3	reviewed	FLVC2_HUMAN	Heme transporter FLVCR2 (Calcium-chelate transporter) (CCT) (Feline leukemia virus subgroup C receptor-related protein 2)	FLVCR2 C14orf58	Homo sapiens (Human)	526	FUNCTION: Putative heme b importer/sensor involved in heme homeostasis in response to the metabolic state of the cell and to diet. May act as a sensor of cytosolic and/or mitochondrial heme levels to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis. At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis. Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis. Alternatively, in coordination with ATP2A2 may mediate calcium transport and signaling in response to heme. {ECO:0000269|PubMed:20823265, ECO:0000269|PubMed:32973183}.		heme export [GO:0097037]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]; heme export [GO:0097037]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:32973183}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:32973183}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000305|PubMed:14729055}; Multi-pass membrane protein {ECO:0000255}. Note=Primarily resides in mitochondria where it interacts with components of the electron transfer chain complexes III, IV and V. Colocalizes with ATP2A2 at the mitochondrial-ER contact junction. {ECO:0000269|PubMed:32973183}.
Q9UPM6	reviewed	LHX6_HUMAN	LIM/homeobox protein Lhx6 (LIM homeobox protein 6) (LIM/homeobox protein Lhx6.1)	LHX6 LHX6.1	Homo sapiens (Human)	363	FUNCTION: Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity). {ECO:0000250}.		cell maturation [GO:0048469]; cerebral cortex GABAergic interneuron migration [GO:0021853]; cerebral cortex radially oriented cell migration [GO:0021799]; cerebral cortex tangential migration [GO:0021800]; forebrain neuron development [GO:0021884]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; cell maturation [GO:0048469]; cerebral cortex GABAergic interneuron migration [GO:0021853]; cerebral cortex radially oriented cell migration [GO:0021799]; cerebral cortex tangential migration [GO:0021800]; forebrain neuron development [GO:0021884]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UPM8	reviewed	AP4E1_HUMAN	AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin)	AP4E1	Homo sapiens (Human)	1137	FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}.		protein localization [GO:0008104]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192]	AP-4 adaptor complex [GO:0030124]; endosome lumen [GO:0031904]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	cargo adaptor activity [GO:0140312]	AP-4 adaptor complex [GO:0030124]; endosome lumen [GO:0031904]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; cargo adaptor activity [GO:0140312]; protein localization [GO:0008104]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000305|PubMed:10436028}; Peripheral membrane protein {ECO:0000305}.
Q9UPM9	reviewed	B9D1_HUMAN	B9 domain-containing protein 1 (MKS1-related protein 1)	B9D1 MKSR1	Homo sapiens (Human)	204	FUNCTION: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250}.		camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224]; vasculature development [GO:0001944]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; membrane [GO:0016020]; MKS complex [GO:0036038]	hedgehog receptor activity [GO:0008158]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; membrane [GO:0016020]; MKS complex [GO:0036038]; hedgehog receptor activity [GO:0008158]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224]; vasculature development [GO:0001944]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19208769}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19208769}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250}.
Q9UPN3	reviewed	MACF1_HUMAN	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)	MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251	Homo sapiens (Human)	7388	FUNCTION: [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.		Golgi to plasma membrane protein transport [GO:0043001]; intermediate filament cytoskeleton organization [GO:0045104]; positive regulation of axon extension [GO:0045773]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of cell migration [GO:0030334]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of microtubule-based process [GO:0032886]; regulation of neuron projection arborization [GO:0150011]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; microtubule minus-end binding [GO:0051011]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; microtubule minus-end binding [GO:0051011]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; Golgi to plasma membrane protein transport [GO:0043001]; intermediate filament cytoskeleton organization [GO:0045104]; positive regulation of axon extension [GO:0045773]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of cell migration [GO:0030334]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of microtubule-based process [GO:0032886]; regulation of neuron projection arborization [GO:0150011]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:27693509}. Cytoplasm {ECO:0000269|PubMed:15265687}. Golgi apparatus {ECO:0000269|PubMed:15265687}. Cell membrane {ECO:0000269|PubMed:20937854}. Cell projection, ruffle membrane {ECO:0000269|PubMed:20937854}. Note=The phosphorylated form is found in the cytoplasm while the non-phosphorylated form associates with the microtubules (By similarity). Localizes to the tips of microtubules (PubMed:27693509). Associated with the minus-end of microtubules via interaction with CAMSAP3 (PubMed:27693509). APC controls its localization to the cell membrane which is critical for its function in microtubule stabilization (PubMed:20937854). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16076900}. Golgi apparatus {ECO:0000269|PubMed:16076900}. Note=Localizes to the tips of microtubules. {ECO:0000269|PubMed:16076900}.
Q9UPN4	reviewed	CP131_HUMAN	Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1)	CEP131 AZI1 KIAA1118	Homo sapiens (Human)	1083	FUNCTION: Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}.	MISCELLANEOUS: Transient cell cultured-based knock-down (by RNAi) of CEP131 leads to a reduction in ciliogenesis (PubMed:17954613, PubMed:24121310). However, analysis of mice with chronic absence of CEP131 following genetic deletion (knockout) shows that cilia develop and function normally in vivo. This suggests that CEP131 is not essential for ciliogenesis, except for the modified cilia of the developing sperm flagella, and that there is an alternative mechanism to compensate for the lack of CEP131. {ECO:0000305|PubMed:17954613, ECO:0000305|PubMed:24121310}.	cell cycle [GO:0007049]; cilium assembly [GO:0060271]; intraciliary transport involved in cilium assembly [GO:0035735]; intramanchette transport [GO:1990953]; manchette assembly [GO:1905198]; non-motile cilium assembly [GO:1905515]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539]; regulation of centrosome duplication [GO:0010824]; sperm axoneme assembly [GO:0007288]	acrosomal vesicle [GO:0001669]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; manchette [GO:0002177]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; sperm head-tail coupling apparatus [GO:0120212]	protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; manchette [GO:0002177]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; sperm head-tail coupling apparatus [GO:0120212]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; cell cycle [GO:0007049]; cilium assembly [GO:0060271]; intraciliary transport involved in cilium assembly [GO:0035735]; intramanchette transport [GO:1990953]; manchette assembly [GO:1905198]; non-motile cilium assembly [GO:1905515]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539]; regulation of centrosome duplication [GO:0010824]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:27224062, ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30804208}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208, ECO:0000269|PubMed:31789463}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30804208}. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q62036}. Note=Colocalized with pericentriolar material protein PCM1 at centriolar satellites. During spermiogenesis, becomes enriched with nephrocystin NPHP1 at the transition zone, a structure at the base of the ciliary axoneme important for regulating traffic into the ciliary compartment. Traffics towards and away from the centrosome/basal body and the transition zone of the ciliary axoneme in a microtubule-dependent manner. Localized at the Golgi-derived acrosome and the centrosome-containing head-tail coupling apparatus (HTCA) (By similarity). Ubiquitinated form is sequestered and colocalized with BBS4, CEP290, PCM1 and PCNT at centriolar satellites in proliferating cells. Colocalized with the pericentriolar material protein PCM1 at centrosome. Traffics towards and away from centriolar satellites and centrosome in a microtubule- and dynein-dependent manner in interphase cells. Displaced from centriolar satellites but still remains associated with the centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAPK signaling (PubMed:26616734). {ECO:0000250, ECO:0000269|PubMed:26616734}.
Q9UPN6	reviewed	SCAF8_HUMAN	SR-related and CTD-associated factor 8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16)	SCAF8 CCAP7 KIAA1116 RBM16	Homo sapiens (Human)	1271	FUNCTION: Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839). {ECO:0000269|PubMed:31104839}.		mRNA polyadenylation [GO:0006378]; negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000805]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; termination of RNA polymerase II transcription [GO:0006369]	cytoplasm [GO:0005737]; mRNA cleavage factor complex [GO:0005849]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA polymerase core enzyme binding [GO:0043175]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; RNA polymerase II complex binding [GO:0000993]	cytoplasm [GO:0005737]; mRNA cleavage factor complex [GO:0005849]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA polymerase core enzyme binding [GO:0043175]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; RNA polymerase II complex binding [GO:0000993]; mRNA polyadenylation [GO:0006378]; negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000805]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:31104839, ECO:0000269|PubMed:9528809}. Nucleus matrix {ECO:0000269|PubMed:9528809}. Note=Detected in granular nuclear foci which correspond to sites of active transcription. {ECO:0000269|PubMed:31104839, ECO:0000269|PubMed:9528809}.
Q9UPN7	reviewed	PP6R1_HUMAN	Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1)	PPP6R1 KIAA1115 PP6R1 SAPS1	Homo sapiens (Human)	881	FUNCTION: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}.		regulation of phosphoprotein phosphatase activity [GO:0043666]	cytosol [GO:0005829]; nucleus [GO:0005634]	protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]; small GTPase binding [GO:0031267]; regulation of phosphoprotein phosphatase activity [GO:0043666]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16769727, ECO:0000269|PubMed:18186651}.
Q9UPN9	reviewed	TRI33_HUMAN	E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)	TRIM33 KIAA1113 RFG7 TIF1G	Homo sapiens (Human)	1127	FUNCTION: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.		negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; R-SMAD binding [GO:0070412]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; R-SMAD binding [GO:0070412]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894, ECO:0000269|PubMed:25593309}. Note=In discrete nuclear dots resembling nuclear bodies (By similarity). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000250|UniProtKB:Q99PP7, ECO:0000269|PubMed:25593309}.
Q9UPP1	reviewed	PHF8_HUMAN	Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8)	PHF8 KIAA1111 ZNF422	Homo sapiens (Human)	1060	FUNCTION: Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}.		brain development [GO:0007420]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of rDNA heterochromatin formation [GO:0061188]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; chromatin binding [GO:0003682]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]	nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; chromatin binding [GO:0003682]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]; brain development [GO:0007420]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of rDNA heterochromatin formation [GO:0061188]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20622854}. Nucleus, nucleolus {ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20531378}. Note=Recruited to H3K4me3 sites on chromatin during interphase (PubMed:20622854). Dissociates from chromatin when cells enter mitosis (PubMed:20622854). {ECO:0000269|PubMed:20622854}.
Q9UPP2	reviewed	IQEC3_HUMAN	IQ motif and SEC7 domain-containing protein 3	IQSEC3 KIAA1110	Homo sapiens (Human)	1182	FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for ARF1. {ECO:0000269|PubMed:17981261}.		actin cytoskeleton organization [GO:0030036]; regulation of ARF protein signal transduction [GO:0032012]	cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; glycinergic synapse [GO:0098690]; inhibitory synapse [GO:0060077]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization of symmetric synapse [GO:0099629]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; glycinergic synapse [GO:0098690]; inhibitory synapse [GO:0060077]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization of symmetric synapse [GO:0099629]; guanyl-nucleotide exchange factor activity [GO:0005085]; actin cytoskeleton organization [GO:0030036]; regulation of ARF protein signal transduction [GO:0032012]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17981261}. Postsynaptic density {ECO:0000250|UniProtKB:Q3TES0}.
Q9UPQ0	reviewed	LIMC1_HUMAN	LIM and calponin homology domains-containing protein 1	LIMCH1 KIAA1102	Homo sapiens (Human)	1083	FUNCTION: Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.		actomyosin structure organization [GO:0031032]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; negative regulation of cell migration [GO:0030336]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; regulation of focal adhesion assembly [GO:0051893]	cytoplasm [GO:0005737]; stress fiber [GO:0001725]	actin binding [GO:0003779]; metal ion binding [GO:0046872]; myosin II head/neck binding [GO:0032034]	cytoplasm [GO:0005737]; stress fiber [GO:0001725]; actin binding [GO:0003779]; metal ion binding [GO:0046872]; myosin II head/neck binding [GO:0032034]; actomyosin structure organization [GO:0031032]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; negative regulation of cell migration [GO:0030336]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; regulation of focal adhesion assembly [GO:0051893]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:28228547}.
Q9UPQ3	reviewed	AGAP1_HUMAN	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)	AGAP1 CENTG2 KIAA1099	Homo sapiens (Human)	857	FUNCTION: GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. {ECO:0000269|PubMed:12640130}.		protein transport [GO:0015031]	cytoplasm [GO:0005737]	GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]	cytoplasm [GO:0005737]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12388557, ECO:0000269|PubMed:12640130}. Note=Associates with the endocytic compartment.
Q9UPQ4	reviewed	TRI35_HUMAN	E3 ubiquitin-protein ligase TRIM35 (EC 2.3.2.27) (Hemopoietic lineage switch protein 5)	TRIM35 HLS5 KIAA1098	Homo sapiens (Human)	493	FUNCTION: E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway (PubMed:32562145). Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145). Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537). Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:25907537, ECO:0000269|PubMed:32562145}.		apoptotic process [GO:0006915]; innate immune response [GO:0045087]; negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of apoptotic process [GO:0043065]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; innate immune response [GO:0045087]; negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of apoptotic process [GO:0043065]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25263439}. Nucleus {ECO:0000250}. Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity). {ECO:0000250}.
Q9UPQ7	reviewed	PZRN3_HUMAN	E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3)	PDZRN3 KIAA1095 LNX3 SEMCAP3	Homo sapiens (Human)	1066	FUNCTION: E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. {ECO:0000250|UniProtKB:Q69ZS0}.		neuromuscular junction development [GO:0007528]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; neuromuscular junction [GO:0031594]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; neuromuscular junction [GO:0031594]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; neuromuscular junction development [GO:0007528]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q69ZS0}. Cytoplasm {ECO:0000250|UniProtKB:E7FDW2}. Note=Localizes to the postsynaptic region of neuromuscular junctions. {ECO:0000250|UniProtKB:Q69ZS0}.
Q9UPQ8	reviewed	DOLK_HUMAN	Dolichol kinase (EC 2.7.1.108) (Transmembrane protein 15)	DOLK KIAA1094 TMEM15 UNQ2422/PRO4980	Homo sapiens (Human)	538	FUNCTION: Catalyzes CTP-mediated phosphorylation of dolichol, the terminal step in de novo dolichyl monophosphate (Dol-P) biosynthesis (PubMed:12213788, PubMed:16923818, PubMed:17273964). Dol-P is a lipid carrier essential for the synthesis of N-linked and O-linked oligosaccharides and for GPI anchors (PubMed:12213788). {ECO:0000269|PubMed:12213788, ECO:0000269|PubMed:16923818, ECO:0000269|PubMed:17273964}.	MISCELLANEOUS: Complements the defects in growth, dolichol kinase activity and protein N-glycosylation at the restrictive temperature in yeast sec59 mutant cells. {ECO:0000269|PubMed:12213788}.	dolichyl diphosphate biosynthetic process [GO:0006489]; dolichyl monophosphate biosynthetic process [GO:0043048]; phosphorylation [GO:0016310]	endoplasmic reticulum membrane [GO:0005789]	dolichol kinase activity [GO:0004168]	endoplasmic reticulum membrane [GO:0005789]; dolichol kinase activity [GO:0004168]; dolichyl diphosphate biosynthetic process [GO:0006489]; dolichyl monophosphate biosynthetic process [GO:0043048]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16923818}; Multi-pass membrane protein {ECO:0000305}.
Q9UPQ9	reviewed	TNR6B_HUMAN	Trinucleotide repeat-containing gene 6B protein	TNRC6B KIAA1093	Homo sapiens (Human)	1833	FUNCTION: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}.		miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulatory ncRNA-mediated gene silencing [GO:0031047]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]	RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RNA binding [GO:0003723]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulatory ncRNA-mediated gene silencing [GO:0031047]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051}. Note=Mammalian P-bodies are also known as GW bodies (GWBs). {ECO:0000269|PubMed:16289642}.
Q9UPR0	reviewed	PLCL2_HUMAN	Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2)	PLCL2 KIAA1092 PLCE2	Homo sapiens (Human)	1127	FUNCTION: May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}.		B cell proliferation involved in immune response [GO:0002322]; B-1a B cell differentiation [GO:0002337]; gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of synaptic transmission, GABAergic [GO:0032228]	cytoplasm [GO:0005737]	GABA receptor binding [GO:0050811]; inositol 1,4,5 trisphosphate binding [GO:0070679]; phosphatidylinositol phospholipase C activity [GO:0004435]	cytoplasm [GO:0005737]; GABA receptor binding [GO:0050811]; inositol 1,4,5 trisphosphate binding [GO:0070679]; phosphatidylinositol phospholipase C activity [GO:0004435]; B cell proliferation involved in immune response [GO:0002322]; B-1a B cell differentiation [GO:0002337]; gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of synaptic transmission, GABAergic [GO:0032228]	SUBCELLULAR LOCATION: Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells. {ECO:0000250}.
Q9UPR3	reviewed	SMG5_HUMAN	Nonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5)	SMG5 EST1B KIAA1089	Homo sapiens (Human)	1016	FUNCTION: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269|PubMed:17053788}.		mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]; regulation of telomere maintenance [GO:0032204]; regulation of telomere maintenance via telomerase [GO:0032210]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]	histone deacetylase binding [GO:0042826]; protein phosphatase 2A binding [GO:0051721]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]; histone deacetylase binding [GO:0042826]; protein phosphatase 2A binding [GO:0051721]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162]; ubiquitin protein ligase binding [GO:0031625]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]; regulation of telomere maintenance [GO:0032204]; regulation of telomere maintenance via telomerase [GO:0032210]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14636577}. Nucleus {ECO:0000269|PubMed:14636577}. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.
Q9UPR5	reviewed	NAC2_HUMAN	Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2)	SLC8A2 KIAA1087 NCX2	Homo sapiens (Human)	921	FUNCTION: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion. {ECO:0000250|UniProtKB:Q8K596}.		calcium ion export across plasma membrane [GO:1990034]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell communication [GO:0007154]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; modulation of excitatory postsynaptic potential [GO:0098815]; monoatomic ion transport [GO:0006811]; neuron cellular homeostasis [GO:0070050]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of action potential firing pattern [GO:0099608]; regulation of calcineurin-mediated signaling [GO:0106056]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of gene expression [GO:0010468]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to ischemia [GO:0002931]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]; transport across blood-brain barrier [GO:0150104]	axon [GO:0030424]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; synapse [GO:0045202]	calcium ion transmembrane transporter activity [GO:0015085]; calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:1905060]; calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; sodium ion transmembrane transporter activity [GO:0015081]	axon [GO:0030424]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; synapse [GO:0045202]; calcium ion transmembrane transporter activity [GO:0015085]; calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:1905060]; calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; sodium ion transmembrane transporter activity [GO:0015081]; calcium ion export across plasma membrane [GO:1990034]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell communication [GO:0007154]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; modulation of excitatory postsynaptic potential [GO:0098815]; monoatomic ion transport [GO:0006811]; neuron cellular homeostasis [GO:0070050]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of action potential firing pattern [GO:0099608]; regulation of calcineurin-mediated signaling [GO:0106056]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of gene expression [GO:0010468]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to ischemia [GO:0002931]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48768}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48768}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8K596}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K596}. Perikaryon {ECO:0000250|UniProtKB:P48768}. Cell projection, dendrite {ECO:0000250|UniProtKB:P48768}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P48768}.
Q9UPS6	reviewed	SET1B_HUMAN	Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)	SETD1B KIAA1076 KMT2G SET1B	Homo sapiens (Human)	1966	FUNCTION: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:25561738, PubMed:17355966). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:17355966). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}.		methylation [GO:0032259]	chromosome [GO:0005694]; histone methyltransferase complex [GO:0035097]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; Set1C/COMPASS complex [GO:0048188]	histone H3 methyltransferase activity [GO:0140938]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; RNA binding [GO:0003723]	chromosome [GO:0005694]; histone methyltransferase complex [GO:0035097]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; Set1C/COMPASS complex [GO:0048188]; histone H3 methyltransferase activity [GO:0140938]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; RNA binding [GO:0003723]; methylation [GO:0032259]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:17355966}. Chromosome {ECO:0000269|PubMed:17355966}. Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes.
Q9UPS8	reviewed	ANR26_HUMAN	Ankyrin repeat domain-containing protein 26	ANKRD26 KIAA1074	Homo sapiens (Human)	1710	FUNCTION: Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. {ECO:0000250|UniProtKB:Q811D2}.		negative regulation of fat cell differentiation [GO:0045599]	centrosome [GO:0005813]		centrosome [GO:0005813]; negative regulation of fat cell differentiation [GO:0045599]	
Q9UPT5	reviewed	EXOC7_HUMAN	Exocyst complex component 7 (Exocyst complex component Exo70)	EXOC7 EXO70 KIAA1067	Homo sapiens (Human)	735	FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). It is required for neuron survival and plays an essential role in cortical development (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:E7FC72}.	MISCELLANEOUS: [Isoform 4]: May be due to intron retention. {ECO:0000305}.	exocytosis [GO:0006887]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of entry of bacterium into host cell [GO:2000535]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone membrane [GO:0032584]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]	phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone membrane [GO:0032584]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; exocytosis [GO:0006887]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of entry of bacterium into host cell [GO:2000535]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O35250}. Cell membrane {ECO:0000250|UniProtKB:O35250}; Peripheral membrane protein {ECO:0000305}. Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Note=Translocates, as a preformed complex with EXOC3/SEC6 and EXOC4/SEC8, to the plasma membrane in response to insulin through the activation of ARHQ (By similarity). Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). {ECO:0000250|UniProtKB:O35250, ECO:0000269|PubMed:16213214}.
Q9UPT6	reviewed	JIP3_HUMAN	C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)	MAPK8IP3 JIP3 KIAA1066	Homo sapiens (Human)	1336	FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}.		anterograde axonal protein transport [GO:0099641]; axon development [GO:0061564]; axon regeneration [GO:0031103]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JNK cascade [GO:0046330]; protein stabilization [GO:0050821]; regulation of JNK cascade [GO:0046328]; vesicle-mediated transport [GO:0016192]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]	JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; signaling receptor complex adaptor activity [GO:0030159]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]; JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; signaling receptor complex adaptor activity [GO:0030159]; anterograde axonal protein transport [GO:0099641]; axon development [GO:0061564]; axon regeneration [GO:0031103]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JNK cascade [GO:0046330]; protein stabilization [GO:0050821]; regulation of JNK cascade [GO:0046328]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ESN9}. Golgi apparatus {ECO:0000250|UniProtKB:Q9ESN9}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9ESN9}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9ESN9}. Cell projection, axon {ECO:0000250|UniProtKB:E9PSK7}. Cell projection, dendrite {ECO:0000250|UniProtKB:E9PSK7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:E9PSK7}. Note=Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells. KIF5A/B/C-mediated transportation to axon tips is essential for its function in enhancing neuronal axon elongation. {ECO:0000250|UniProtKB:E9PSK7, ECO:0000250|UniProtKB:Q9ESN9}.
Q9UPT8	reviewed	ZC3H4_HUMAN	Zinc finger CCCH domain-containing protein 4	ZC3H4 C19orf7 KIAA1064	Homo sapiens (Human)	1303	FUNCTION: RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33913806, PubMed:33767452). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33913806, PubMed:33767452). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33913806, PubMed:33767452). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}.		DNA-templated transcription termination [GO:0006353]; lncRNA catabolic process [GO:0110064]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of lncRNA transcription [GO:0140744]; nuclear RNA surveillance [GO:0071027]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; DNA-templated transcription termination [GO:0006353]; lncRNA catabolic process [GO:0110064]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of lncRNA transcription [GO:0140744]; nuclear RNA surveillance [GO:0071027]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:33913806}. Note=Recruited at sites of high RNA polymerase II occupancy. {ECO:0000269|PubMed:33913806}.
Q9UPT9	reviewed	UBP22_HUMAN	Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22)	USP22 KIAA1063 USP3L	Homo sapiens (Human)	525	FUNCTION: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression. {ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:18206973, ECO:0000269|PubMed:18469533}.		cell cycle [GO:0007049]; embryo development ending in birth or egg hatching [GO:0009792]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cell cycle [GO:0045931]; protein deubiquitination [GO:0016579]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]	cysteine-type deubiquitinase activity [GO:0004843]; enzyme binding [GO:0019899]; histone H2B deubiquitinase activity [GO:0140936]; nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276]; cysteine-type deubiquitinase activity [GO:0004843]; enzyme binding [GO:0019899]; histone H2B deubiquitinase activity [GO:0140936]; nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; embryo development ending in birth or egg hatching [GO:0009792]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cell cycle [GO:0045931]; protein deubiquitination [GO:0016579]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5DU02}.
Q9UPU5	reviewed	UBP24_HUMAN	Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24)	USP24 KIAA1057	Homo sapiens (Human)	2620	FUNCTION: Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}.		proteolysis [GO:0006508]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]	
Q9UPU7	reviewed	TBD2B_HUMAN	TBC1 domain family member 2B	TBC1D2B KIAA1055	Homo sapiens (Human)	963	FUNCTION: GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}.		endocytosis [GO:0006897]	cytosol [GO:0005829]; early endosome [GO:0005769]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; early endosome [GO:0005769]; GTPase activator activity [GO:0005096]; endocytosis [GO:0006897]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:32623794}.
Q9UPU9	reviewed	SMAG1_HUMAN	Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A)	SAMD4A KIAA1053 SAMD4 SMAUG1	Homo sapiens (Human)	718	FUNCTION: Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}.		nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of translation [GO:0045727]	cell junction [GO:0030054]; cytosol [GO:0005829]; dendrite [GO:0030425]; fibrillar center [GO:0001650]; P-body [GO:0000932]; synapse [GO:0045202]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation repressor activity [GO:0030371]	cell junction [GO:0030054]; cytosol [GO:0005829]; dendrite [GO:0030425]; fibrillar center [GO:0001650]; P-body [GO:0000932]; synapse [GO:0045202]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation repressor activity [GO:0030371]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of translation [GO:0045727]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16221671}. Cell projection, dendrite {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=Enriched in synaptoneurosomes (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1. {ECO:0000250}.
Q9UPV0	reviewed	CE164_HUMAN	Centrosomal protein of 164 kDa (Cep164)	CEP164 KIAA1052 NPHP15	Homo sapiens (Human)	1460	FUNCTION: Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}.		cell cycle [GO:0007049]; cell division [GO:0051301]; cilium assembly [GO:0060271]; DNA repair [GO:0006281]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; cell cycle [GO:0007049]; cell division [GO:0051301]; cilium assembly [GO:0060271]; DNA repair [GO:0006281]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26337392}. Nucleus. Note=Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation (PubMed:26337392). Persisted at centrioles throughout mitosis. Expressed in chromatin-enriched nuclear fraction of HeLa cells. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1. {ECO:0000269|PubMed:26337392}.
Q9UPV7	reviewed	PHF24_HUMAN	PHD finger protein 24	PHF24 KIAA1045	Homo sapiens (Human)	400			detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synaptic transmission, GABAergic [GO:0032228]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synaptic transmission, GABAergic [GO:0032228]	
Q9UPV9	reviewed	TRAK1_HUMAN	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton)	TRAK1 KIAA1042 OIP106	Homo sapiens (Human)	953	FUNCTION: Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). {ECO:0000250|UniProtKB:Q960V3, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:24995978}.	MISCELLANEOUS: Over-expressed in all investigated carcinomas, especially in gastric adenocarcinoma and signet-ring carcinoma and may serve as a marker of gastric cancer.	anterograde axonal transport of mitochondrion [GO:0098957]; dendrite morphogenesis [GO:0048813]; endosome to lysosome transport [GO:0008333]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; positive regulation of axonogenesis [GO:0050772]; protein O-linked glycosylation [GO:0006493]; protein targeting [GO:0006605]; regulation of transcription by RNA polymerase II [GO:0006357]; vesicle transport along microtubule [GO:0047496]	axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GABA receptor binding [GO:0050811]; myosin binding [GO:0017022]; TPR domain binding [GO:0030911]	axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; GABA receptor binding [GO:0050811]; myosin binding [GO:0017022]; TPR domain binding [GO:0030911]; anterograde axonal transport of mitochondrion [GO:0098957]; dendrite morphogenesis [GO:0048813]; endosome to lysosome transport [GO:0008333]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; positive regulation of axonogenesis [GO:0050772]; protein O-linked glycosylation [GO:0006493]; protein targeting [GO:0006605]; regulation of transcription by RNA polymerase II [GO:0006357]; vesicle transport along microtubule [GO:0047496]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18986759}. Nucleus {ECO:0000269|PubMed:12435728}. Mitochondrion {ECO:0000269|PubMed:15644324, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:19528298}. Early endosome {ECO:0000269|PubMed:18675823}. Endosome {ECO:0000269|PubMed:18675823}. Mitochondrion membrane {ECO:0000269|PubMed:24995978}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q6PD31}. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HGS/HRS (PubMed:18675823). Colocalizes with MGARP at the mitochondria (PubMed:19528298). {ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:19528298}.
Q9UPW0	reviewed	FOXJ3_HUMAN	Forkhead box protein J3	FOXJ3 KIAA1041	Homo sapiens (Human)	622	FUNCTION: Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (By similarity). Plays an important role in spermatogenesis (By similarity). Required for the survival of spermatogonia and participates in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q8BUR3}.		cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Q9UPW5	reviewed	CBPC1_HUMAN	Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1 homolog) (Protein deglutamylase CCP1)	AGTPBP1 CCP1 KIAA1035 NNA1	Homo sapiens (Human)	1226	FUNCTION: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:22170066, PubMed:24022482, PubMed:30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:22170066, PubMed:24022482, PubMed:30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:24022482). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). {ECO:0000269|PubMed:22170066, ECO:0000269|PubMed:24022482, ECO:0000269|PubMed:29593216, ECO:0000269|PubMed:30420557}.		adult walking behavior [GO:0007628]; anterograde axonal transport of mitochondrion [GO:0098957]; C-terminal protein deglutamylation [GO:0035609]; central nervous system neuron development [GO:0021954]; cerebellar Purkinje cell differentiation [GO:0021702]; eye photoreceptor cell differentiation [GO:0001754]; mitochondrion organization [GO:0007005]; negative regulation of cell population proliferation [GO:0008285]; neuromuscular process [GO:0050905]; neurotransmitter metabolic process [GO:0042133]; olfactory bulb development [GO:0021772]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]; retina development in camera-type eye [GO:0060041]; retrograde axonal transport of mitochondrion [GO:0098958]	axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]	metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]	axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]; adult walking behavior [GO:0007628]; anterograde axonal transport of mitochondrion [GO:0098957]; C-terminal protein deglutamylation [GO:0035609]; central nervous system neuron development [GO:0021954]; cerebellar Purkinje cell differentiation [GO:0021702]; eye photoreceptor cell differentiation [GO:0001754]; mitochondrion organization [GO:0007005]; negative regulation of cell population proliferation [GO:0008285]; neuromuscular process [GO:0050905]; neurotransmitter metabolic process [GO:0042133]; olfactory bulb development [GO:0021772]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]; retina development in camera-type eye [GO:0060041]; retrograde axonal transport of mitochondrion [GO:0098958]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17244818, ECO:0000269|PubMed:23085998}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q641K1}. Nucleus {ECO:0000269|PubMed:23085998}. Mitochondrion {ECO:0000250|UniProtKB:Q641K1}. Note=Localizes in both the cytoplasm and nuclei of interphase and dividing cells. {ECO:0000269|PubMed:23085998}.
Q9UPW6	reviewed	SATB2_HUMAN	DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2)	SATB2 KIAA1034	Homo sapiens (Human)	733	FUNCTION: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}.		cartilage development [GO:0051216]; cellular response to organic substance [GO:0071310]; chromatin remodeling [GO:0006338]; embryonic pattern specification [GO:0009880]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; osteoblast development [GO:0002076]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]	chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cartilage development [GO:0051216]; cellular response to organic substance [GO:0071310]; chromatin remodeling [GO:0006338]; embryonic pattern specification [GO:0009880]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; osteoblast development [GO:0002076]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00374, ECO:0000269|PubMed:14701874}.
Q9UPW8	reviewed	UN13A_HUMAN	Protein unc-13 homolog A (Munc13-1)	UNC13A KIAA1032	Homo sapiens (Human)	1703	FUNCTION: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q4KUS2, ECO:0000250|UniProtKB:Q62768, ECO:0000269|PubMed:23999003}.		cell differentiation [GO:0030154]; dense core granule priming [GO:0061789]; neuromuscular junction development [GO:0007528]; neuronal dense core vesicle exocytosis [GO:0099011]; neurotransmitter secretion [GO:0007269]; positive regulation of dendrite extension [GO:1903861]; presynaptic dense core vesicle exocytosis [GO:0099525]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle priming [GO:0016082]	neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543]; syntaxin-1 binding [GO:0017075]	neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543]; syntaxin-1 binding [GO:0017075]; cell differentiation [GO:0030154]; dense core granule priming [GO:0061789]; neuromuscular junction development [GO:0007528]; neuronal dense core vesicle exocytosis [GO:0099011]; neurotransmitter secretion [GO:0007269]; positive regulation of dendrite extension [GO:1903861]; presynaptic dense core vesicle exocytosis [GO:0099525]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle priming [GO:0016082]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q62768}. Cell membrane {ECO:0000250|UniProtKB:Q62768}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62768}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q62768}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62768}. Presynaptic active zone {ECO:0000250|UniProtKB:Q62768}. Note=Translocated to the plasma membrane in response to phorbol ester binding. {ECO:0000250|UniProtKB:Q62768}.
Q9UPX6	reviewed	MNAR1_HUMAN	Major intrinsically disordered Notch2-binding receptor 1 (Membrane integral NOTCH2-associated receptor 1) (Ubiquitination and mTOR signaling protein)	MINAR1 KIAA1024 UBTOR	Homo sapiens (Human)	916	FUNCTION: Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR (PubMed:30080879). Negatively regulates angiogenesis (PubMed:29329397). Negatively regulates cell growth (PubMed:29329397, PubMed:30080879). Negatively regulates neurite outgrowth in hippocampal neurons (By similarity). {ECO:0000250|UniProtKB:D3ZJ47, ECO:0000269|PubMed:29329397, ECO:0000269|PubMed:30080879}.		angiogenesis [GO:0001525]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of TOR signaling [GO:0032007]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; angiogenesis [GO:0001525]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of TOR signaling [GO:0032007]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29329397, ECO:0000269|PubMed:30080879}; Single-pass type IV membrane protein {ECO:0000269|PubMed:30080879}.
Q9UPX8	reviewed	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)	SHANK2 CORTBP1 KIAA1022 PROSAP1	Homo sapiens (Human)	1849	FUNCTION: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.	MISCELLANEOUS: [Isoform 3]: Contains 6 ANK repeats at positions 196-226, 230-259, 263-293, 297-326, 330-359, 363-393. {ECO:0000305}.	adult behavior [GO:0030534]; adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; learning [GO:0007612]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; negative regulation of hippo signaling [GO:0035331]; positive regulation of cell population proliferation [GO:0008284]; regulation of postsynapse organization [GO:0099175]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]	ionotropic glutamate receptor binding [GO:0035255]; SH3 domain binding [GO:0017124]; structural constituent of postsynaptic density [GO:0098919]; synaptic receptor adaptor activity [GO:0030160]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; ionotropic glutamate receptor binding [GO:0035255]; SH3 domain binding [GO:0017124]; structural constituent of postsynaptic density [GO:0098919]; synaptic receptor adaptor activity [GO:0030160]; adult behavior [GO:0030534]; adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; learning [GO:0007612]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; negative regulation of hippo signaling [GO:0035331]; positive regulation of cell population proliferation [GO:0008284]; regulation of postsynapse organization [GO:0099175]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Synapse {ECO:0000250}. Postsynaptic density {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity). {ECO:0000250}.
Q9UPY3	reviewed	DICER_HUMAN	Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI)	DICER1 DICER HERNA KIAA0928	Homo sapiens (Human)	1922	FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}.		apoptotic DNA fragmentation [GO:0006309]; global gene silencing by mRNA cleavage [GO:0098795]; miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; negative regulation of gene expression [GO:0010629]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; nerve development [GO:0021675]; neuron projection morphogenesis [GO:0048812]; non-canonical NF-kappaB signal transduction [GO:0038061]; peripheral nervous system myelin formation [GO:0032290]; positive regulation of myelination [GO:0031643]; positive regulation of Schwann cell differentiation [GO:0014040]; pre-miRNA processing [GO:0031054]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422]; tRNA catabolic process [GO:0016078]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]	ATP binding [GO:0005524]; deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; pre-miRNA binding [GO:0070883]; protein domain specific binding [GO:0019904]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; siRNA binding [GO:0035197]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]; ATP binding [GO:0005524]; deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; pre-miRNA binding [GO:0070883]; protein domain specific binding [GO:0019904]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; siRNA binding [GO:0035197]; apoptotic DNA fragmentation [GO:0006309]; global gene silencing by mRNA cleavage [GO:0098795]; miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; negative regulation of gene expression [GO:0010629]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; nerve development [GO:0021675]; neuron projection morphogenesis [GO:0048812]; non-canonical NF-kappaB signal transduction [GO:0038061]; peripheral nervous system myelin formation [GO:0032290]; positive regulation of myelination [GO:0031643]; positive regulation of Schwann cell differentiation [GO:0014040]; pre-miRNA processing [GO:0031054]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422]; tRNA catabolic process [GO:0016078]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16424907}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19022417}.
Q9UPY5	reviewed	XCT_HUMAN	Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)	SLC7A11	Homo sapiens (Human)	501	FUNCTION: Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:15151999, PubMed:34880232, PubMed:35352032, PubMed:35245456, PubMed:11417227, PubMed:14722095, PubMed:11133847). Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress (By similarity). The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine (PubMed:11417227, PubMed:11133847). In addition, mediates the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis (PubMed:35245456). Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis (PubMed:34120018). In vitro can also transport L-aspartate (PubMed:11417227). May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons (By similarity). Controls the production of pheomelanin pigment directly (By similarity). {ECO:0000250|UniProtKB:Q9WTR6, ECO:0000269|PubMed:11133847, ECO:0000269|PubMed:11417227, ECO:0000269|PubMed:14722095, ECO:0000269|PubMed:15151999, ECO:0000269|PubMed:34120018, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35245456, ECO:0000269|PubMed:35352032}.		adult behavior [GO:0030534]; amino acid transmembrane transport [GO:0003333]; cellular response to oxidative stress [GO:0034599]; dipeptide import across plasma membrane [GO:0140206]; glutathione metabolic process [GO:0006749]; glutathione transmembrane transport [GO:0034775]; intracellular glutamate homeostasis [GO:0090461]; L-cystine transport [GO:0015811]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; L-kynurenine transmembrane transport [GO:0140924]; lens fiber cell differentiation [GO:0070306]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of ferroptosis [GO:0110076]; platelet aggregation [GO:0070527]; regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of cell population proliferation [GO:0042127]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cysteine metabolic process [GO:1901494]; regulation of glutamate metabolic process [GO:2000211]; regulation of glutathione biosynthetic process [GO:1903786]; regulation of melanin biosynthetic process [GO:0048021]; regulation of neutrophil apoptotic process [GO:0033029]; regulation of protein transport [GO:0051223]; regulation of synapse organization [GO:0050807]; response to nicotine [GO:0035094]; response to organic cyclic compound [GO:0014070]; response to redox state [GO:0051775]; response to toxic substance [GO:0009636]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual learning [GO:0008542]	apical part of cell [GO:0045177]; astrocyte projection [GO:0097449]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	cystine:glutamate antiporter activity [GO:0015327]; L-amino acid transmembrane transporter activity [GO:0015179]; L-kynurenine transmembrane transporter activity [GO:0140926]	apical part of cell [GO:0045177]; astrocyte projection [GO:0097449]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; cystine:glutamate antiporter activity [GO:0015327]; L-amino acid transmembrane transporter activity [GO:0015179]; L-kynurenine transmembrane transporter activity [GO:0140926]; adult behavior [GO:0030534]; amino acid transmembrane transport [GO:0003333]; cellular response to oxidative stress [GO:0034599]; dipeptide import across plasma membrane [GO:0140206]; glutathione metabolic process [GO:0006749]; glutathione transmembrane transport [GO:0034775]; intracellular glutamate homeostasis [GO:0090461]; L-cystine transport [GO:0015811]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; L-kynurenine transmembrane transport [GO:0140924]; lens fiber cell differentiation [GO:0070306]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of ferroptosis [GO:0110076]; platelet aggregation [GO:0070527]; regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of cell population proliferation [GO:0042127]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cysteine metabolic process [GO:1901494]; regulation of glutamate metabolic process [GO:2000211]; regulation of glutathione biosynthetic process [GO:1903786]; regulation of melanin biosynthetic process [GO:0048021]; regulation of neutrophil apoptotic process [GO:0033029]; regulation of protein transport [GO:0051223]; regulation of synapse organization [GO:0050807]; response to nicotine [GO:0035094]; response to organic cyclic compound [GO:0014070]; response to redox state [GO:0051775]; response to toxic substance [GO:0009636]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11417227, ECO:0000269|PubMed:15151999, ECO:0000269|PubMed:34880232}; Multi-pass membrane protein {ECO:0000269|PubMed:15151999}. Cell projection, microvillus membrane {ECO:0000269|PubMed:34120018}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the microvillous membrane of the placental syncytiotrophoblast. {ECO:0000269|PubMed:34120018}.
Q9UPY6	reviewed	WASF3_HUMAN	Actin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3)	WASF3 KIAA0900 SCAR3 WAVE3	Homo sapiens (Human)	502	FUNCTION: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:21834987}.		actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; modification of postsynaptic actin cytoskeleton [GO:0098885]; oligodendrocyte development [GO:0014003]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of myelination [GO:0031643]; protein-containing complex assembly [GO:0065003]; regulation of cell shape [GO:0008360]	cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; postsynapse [GO:0098794]; SCAR complex [GO:0031209]	actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; protein kinase A regulatory subunit binding [GO:0034237]	cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; postsynapse [GO:0098794]; SCAR complex [GO:0031209]; actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; protein kinase A regulatory subunit binding [GO:0034237]; actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; modification of postsynaptic actin cytoskeleton [GO:0098885]; oligodendrocyte development [GO:0014003]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of myelination [GO:0031643]; protein-containing complex assembly [GO:0065003]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
Q9UPY8	reviewed	MARE3_HUMAN	Microtubule-associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End-binding protein 3) (EB3) (RP3)	MAPRE3	Homo sapiens (Human)	281	FUNCTION: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:28814570, PubMed:19255245). Promotes microtubule growth (PubMed:28814570, PubMed:19255245). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:28814570, PubMed:19255245). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). {ECO:0000269|PubMed:19255245, ECO:0000269|PubMed:28814570}.		cell division [GO:0051301]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein kinase activity [GO:0045860]; protein localization [GO:0008104]; protein localization to microtubule [GO:0035372]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225]	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; midbody [GO:0030496]; mitotic spindle astral microtubule end [GO:1905721]; perinuclear region of cytoplasm [GO:0048471]; spindle midzone [GO:0051233]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; midbody [GO:0030496]; mitotic spindle astral microtubule end [GO:1905721]; perinuclear region of cytoplasm [GO:0048471]; spindle midzone [GO:0051233]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901]; cell division [GO:0051301]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein kinase activity [GO:0045860]; protein localization [GO:0008104]; protein localization to microtubule [GO:0035372]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10644998, ECO:0000269|PubMed:19255245, ECO:0000269|PubMed:28814570}. Note=Associated with the microtubule network. Detected at the plus end of microtubules. {ECO:0000269|PubMed:10644998, ECO:0000269|PubMed:19255245, ECO:0000269|PubMed:28814570}.
Q9UPZ3	reviewed	HPS5_HUMAN	BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2)	HPS5 AIBP63 KIAA1017	Homo sapiens (Human)	1129	FUNCTION: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}.		blood coagulation [GO:0007596]; developmental pigmentation [GO:0048066]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]	BLOC-2 complex [GO:0031084]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]		BLOC-2 complex [GO:0031084]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; blood coagulation [GO:0007596]; developmental pigmentation [GO:0048066]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15030569}.
Q9UPZ6	reviewed	THS7A_HUMAN	Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]	THSD7A KIAA0960	Homo sapiens (Human)	1657	FUNCTION: [Thrombospondin type-1 domain-containing protein 7A]: Plays a role in actin cytoskeleton rearrangement. {ECO:0000269|PubMed:27214550}.; FUNCTION: [Thrombospondin type-1 domain-containing protein 7A, soluble form]: The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism. {ECO:0000269|PubMed:22194972}.		actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]	cell projection [GO:0042995]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]		cell projection [GO:0042995]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]	SUBCELLULAR LOCATION: [Thrombospondin type-1 domain-containing protein 7A]: Cell membrane {ECO:0000269|PubMed:22194972, ECO:0000269|PubMed:25394321, ECO:0000269|PubMed:27214550}; Single-pass type I membrane protein {ECO:0000269|PubMed:22194972}. Cell projection {ECO:0000250|UniProtKB:Q69ZU6}. Note=Detected on podocyte foot processes. {ECO:0000250|UniProtKB:Q69ZU6}.; SUBCELLULAR LOCATION: [Thrombospondin type-1 domain-containing protein 7A, soluble form]: Secreted {ECO:0000269|PubMed:22194972}. Note=Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form. {ECO:0000269|PubMed:22194972}.
Q9UPZ9	reviewed	CILK1_HUMAN	Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Ciliogenesis associated kinase 1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK)	CILK1 ICK KIAA0936	Homo sapiens (Human)	632	FUNCTION: Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity). {ECO:0000250|UniProtKB:Q62726, ECO:0000250|UniProtKB:Q9JKV2, ECO:0000269|PubMed:24797473, ECO:0000269|PubMed:24853502}.		cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; intraciliary anterograde transport [GO:0035720]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; intraciliary anterograde transport [GO:0035720]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12103360, ECO:0000269|PubMed:19185282}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q62726}. Cell projection, cilium {ECO:0000269|PubMed:24797473}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9JKV2}. Note=Also found at the ciliary tip (PubMed:24797473). Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360, PubMed:19185282). {ECO:0000269|PubMed:12103360, ECO:0000269|PubMed:19185282, ECO:0000269|PubMed:24797473}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15988018}. Note=Predominant cytoplasmic localization has been observed with a N-terminally GFP-tagged construct. {ECO:0000269|PubMed:15988018}.
Q9UQ03	reviewed	COR2B_HUMAN	Coronin-2B (Coronin-like protein C) (Clipin-C) (Protein FC96)	CORO2B KIAA0925	Homo sapiens (Human)	480	FUNCTION: May play a role in the reorganization of neuronal actin structure.		actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of establishment of protein localization [GO:1904950]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of establishment of protein localization [GO:1904951]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cellular response to stress [GO:0080135]; regulation of glomerular filtration [GO:0003093]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; membrane [GO:0016020]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; talin binding [GO:1990147]; vinculin binding [GO:0017166]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; membrane [GO:0016020]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; talin binding [GO:1990147]; vinculin binding [GO:0017166]; actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of establishment of protein localization [GO:1904950]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of establishment of protein localization [GO:1904951]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cellular response to stress [GO:0080135]; regulation of glomerular filtration [GO:0003093]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
Q9UQ05	reviewed	KCNH4_HUMAN	Potassium voltage-gated channel subfamily H member 4 (Brain-specific eag-like channel 2) (BEC2) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Voltage-gated potassium channel subunit Kv12.3)	KCNH4	Homo sapiens (Human)	1017	FUNCTION: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly.		potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	voltage-gated potassium channel activity [GO:0005249]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9UQ07	reviewed	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1)	MOK RAGE RAGE1	Homo sapiens (Human)	419	FUNCTION: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250|UniProtKB:Q9WVS4}.		intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9WVS4}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9WVS4}. Nucleus {ECO:0000250|UniProtKB:Q9WVS4}.
Q9UQ13	reviewed	SHOC2_HUMAN	Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog)	SHOC2 KIAA0862	Homo sapiens (Human)	582	FUNCTION: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. {ECO:0000269|PubMed:10783161, ECO:0000269|PubMed:16630891, ECO:0000269|PubMed:25137548}.		cellular response to growth hormone stimulus [GO:0071378]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron differentiation [GO:0045665]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 1 complex [GO:0000164]	protein phosphatase 1 binding [GO:0008157]; protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 1 complex [GO:0000164]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]; cellular response to growth hormone stimulus [GO:0071378]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron differentiation [GO:0045665]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19684605, ECO:0000269|PubMed:25137548}. Nucleus {ECO:0000269|PubMed:19684605, ECO:0000269|PubMed:25137548}. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation. {ECO:0000269|PubMed:19684605}.
Q9UQ16	reviewed	DYN3_HUMAN	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)	DNM3 KIAA0820	Homo sapiens (Human)	869	FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). {ECO:0000250}.		endocytosis [GO:0006897]; filopodium assembly [GO:0046847]; negative regulation of dendritic spine morphogenesis [GO:0061002]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of synaptic vesicle recycling [GO:1903423]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; receptor internalization [GO:0031623]; synapse assembly [GO:0007416]; synaptic vesicle endocytosis [GO:0048488]	apical tubulobulbar complex [GO:0061828]; axon [GO:0030424]; basal tubulobulbar complex [GO:0061829]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; dendritic spine head [GO:0044327]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic endocytic zone membrane [GO:0098844]; presynapse [GO:0098793]; synaptic cleft [GO:0043083]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; nitric-oxide synthase binding [GO:0050998]; protein serine/threonine kinase binding [GO:0120283]; structural constituent of postsynapse [GO:0099186]; type 1 metabotropic glutamate receptor binding [GO:0031798]; type 5 metabotropic glutamate receptor binding [GO:0031802]	apical tubulobulbar complex [GO:0061828]; axon [GO:0030424]; basal tubulobulbar complex [GO:0061829]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; dendritic spine head [GO:0044327]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic endocytic zone membrane [GO:0098844]; presynapse [GO:0098793]; synaptic cleft [GO:0043083]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; nitric-oxide synthase binding [GO:0050998]; protein serine/threonine kinase binding [GO:0120283]; structural constituent of postsynapse [GO:0099186]; type 1 metabotropic glutamate receptor binding [GO:0031798]; type 5 metabotropic glutamate receptor binding [GO:0031802]; endocytosis [GO:0006897]; filopodium assembly [GO:0046847]; negative regulation of dendritic spine morphogenesis [GO:0061002]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of synaptic vesicle recycling [GO:1903423]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; receptor internalization [GO:0031623]; synapse assembly [GO:0007416]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}. Note=Microtubule-associated. {ECO:0000305}.
Q9UQ26	reviewed	RIMS2_HUMAN	Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3)	RIMS2 KIAA0751 RAB3IP3 RIM2	Homo sapiens (Human)	1411	FUNCTION: Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be due to an intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be due to an intron retention. {ECO:0000305}.	adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of synaptic transmission [GO:0050806]; regulation of exocytosis [GO:0017157]; regulation of membrane potential [GO:0042391]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300]; spontaneous neurotransmitter secretion [GO:0061669]	cell projection [GO:0042995]; cytoskeleton of presynaptic active zone [GO:0048788]; extracellular exosome [GO:0070062]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]	metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]	cell projection [GO:0042995]; cytoskeleton of presynaptic active zone [GO:0048788]; extracellular exosome [GO:0070062]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of synaptic transmission [GO:0050806]; regulation of exocytosis [GO:0017157]; regulation of membrane potential [GO:0042391]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300]; spontaneous neurotransmitter secretion [GO:0061669]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q9UQ35	reviewed	SRRM2_HUMAN	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	Homo sapiens (Human)	2752	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.	MISCELLANEOUS: Can functionally substitute for CWC12 in yeast. {ECO:0000305|PubMed:19854871}.	mRNA splicing, via spliceosome [GO:0000398]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]	C2H2 zinc finger domain binding [GO:0070742]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; C2H2 zinc finger domain binding [GO:0070742]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28062851, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154}. Nucleus speckle {ECO:0000269|PubMed:9531537}.
Q9UQ49	reviewed	NEUR3_HUMAN	Sialidase-3 (EC 3.2.1.18) (Ganglioside sialidasedis) (Membrane sialidase) (N-acetyl-alpha-neuraminidase 3)	NEU3	Homo sapiens (Human)	428	FUNCTION: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:11298736, PubMed:15847605, PubMed:10861246, PubMed:20511247, PubMed:28646141, PubMed:10405317, PubMed:12011038). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR (PubMed:17334392, PubMed:25922362). Desialylates EGFR and activates downstream signaling in proliferating cells (PubMed:25922362). Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (PubMed:26251452). {ECO:0000269|PubMed:10405317, ECO:0000269|PubMed:10861246, ECO:0000269|PubMed:11298736, ECO:0000269|PubMed:12011038, ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:17334392, ECO:0000269|PubMed:20511247, ECO:0000269|PubMed:25922362, ECO:0000269|PubMed:26251452, ECO:0000269|PubMed:28646141}.		carbohydrate metabolic process [GO:0005975]; ganglioside catabolic process [GO:0006689]; glycosphingolipid metabolic process [GO:0006687]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; oligosaccharide catabolic process [GO:0009313]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]	caveola [GO:0005901]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; external side of plasma membrane [GO:0009897]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	alpha-sialidase activity [GO:0016997]; exo-alpha-(2->3)-sialidase activity [GO:0052794]; exo-alpha-(2->6)-sialidase activity [GO:0052795]; exo-alpha-(2->8)-sialidase activity [GO:0052796]; exo-alpha-sialidase activity [GO:0004308]	caveola [GO:0005901]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; external side of plasma membrane [GO:0009897]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; alpha-sialidase activity [GO:0016997]; exo-alpha-(2->3)-sialidase activity [GO:0052794]; exo-alpha-(2->6)-sialidase activity [GO:0052795]; exo-alpha-(2->8)-sialidase activity [GO:0052796]; exo-alpha-sialidase activity [GO:0004308]; carbohydrate metabolic process [GO:0005975]; ganglioside catabolic process [GO:0006689]; glycosphingolipid metabolic process [GO:0006687]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; oligosaccharide catabolic process [GO:0009313]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10861246, ECO:0000269|PubMed:17708748, ECO:0000269|PubMed:26251452, ECO:0000269|PubMed:28646141}; Peripheral membrane protein {ECO:0000269|PubMed:10861246, ECO:0000269|PubMed:17708748}. Membrane, caveola {ECO:0000269|PubMed:12011038}. Early endosome membrane {ECO:0000269|PubMed:26251452}; Peripheral membrane protein {ECO:0000305|PubMed:26251452}. Recycling endosome membrane {ECO:0000269|PubMed:26251452}; Peripheral membrane protein {ECO:0000305|PubMed:26251452}. Lysosome membrane {ECO:0000269|PubMed:26251452}; Peripheral membrane protein {ECO:0000305|PubMed:26251452}. Note=Associates with the external leaflet of the plasma membrane (By similarity). S-acylated NEU3 likely spans the lipid bilayer with a portion of C-terminus exposed to the cytosol and the catalytic region facing the extracellular space (PubMed:28646141). {ECO:0000250|UniProtKB:Q9JMH7, ECO:0000269|PubMed:28646141}.
Q9UQ52	reviewed	CNTN6_HUMAN	Contactin-6 (Neural recognition molecule NB-3) (hNB-3)	CNTN6	Homo sapiens (Human)	1028	FUNCTION: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]	axon [GO:0030424]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; side of membrane [GO:0098552]	cell-cell adhesion mediator activity [GO:0098632]	axon [GO:0030424]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; side of membrane [GO:0098552]; cell-cell adhesion mediator activity [GO:0098632]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Q9UQ53	reviewed	MGT4B_HUMAN	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb) (GlcNAc-T IVb) (GnT-IVb) (N-acetylglucosaminyltransferase IVb) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb)	MGAT4B UNQ906/PRO1927	Homo sapiens (Human)	548	FUNCTION: Glycosyltransferase that catalyzes the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:17006639, PubMed:10372966). Prefers complex-type N-glycans over hybrid-types (PubMed:17006639). Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis (PubMed:17006639). {ECO:0000269|PubMed:10372966, ECO:0000269|PubMed:17006639}.		N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]	acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]; metal ion binding [GO:0046872]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]; metal ion binding [GO:0046872]; N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9D4R2}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9D4R2}. Note=A processed soluble form also exists. {ECO:0000269|PubMed:17006639}.
Q9UQ80	reviewed	PA2G4_HUMAN	Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1)	PA2G4 EBP1	Homo sapiens (Human)	394	FUNCTION: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}.		negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell differentiation [GO:0045597]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell differentiation [GO:0045597]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Nucleus, nucleolus {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Note=Translocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269|PubMed:16832058}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}.
Q9UQ84	reviewed	EXO1_HUMAN	Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI)	EXO1 EXOI HEX1	Homo sapiens (Human)	846	FUNCTION: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}.		DNA recombination [GO:0006310]; DNA repair [GO:0006281]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; isotype switching [GO:0045190]; meiotic cell cycle [GO:0051321]; mismatch repair [GO:0006298]; somatic hypermutation of immunoglobulin genes [GO:0016446]; t-circle formation [GO:0090656]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	5'-3' DNA exonuclease activity [GO:0035312]; 5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded DNA 5'-3' exodeoxyribonuclease activity [GO:0051908]; exonuclease activity [GO:0004527]; flap endonuclease activity [GO:0048256]; metal ion binding [GO:0046872]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; 5'-3' DNA exonuclease activity [GO:0035312]; 5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded DNA 5'-3' exodeoxyribonuclease activity [GO:0051908]; exonuclease activity [GO:0004527]; flap endonuclease activity [GO:0048256]; metal ion binding [GO:0046872]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; isotype switching [GO:0045190]; meiotic cell cycle [GO:0051321]; mismatch repair [GO:0006298]; somatic hypermutation of immunoglobulin genes [GO:0016446]; t-circle formation [GO:0090656]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11429708, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:17426132}. Note=Colocalizes with PCNA to discrete nuclear foci in S-phase.
Q9UQ88	reviewed	CD11A_HUMAN	Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)	CDK11A CDC2L2 CDC2L3 PITSLREB	Homo sapiens (Human)	783	FUNCTION: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}.	MISCELLANEOUS: Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.; MISCELLANEOUS: [Isoform 4]: Produced by alternative initiation at Met-345 of isoform SV6. {ECO:0000305}.	apoptotic process [GO:0006915]; mitotic cell cycle [GO:0000278]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of centrosome cycle [GO:0046605]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of mRNA processing [GO:0050684]; regulation of RNA splicing [GO:0043484]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; mitotic cell cycle [GO:0000278]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of centrosome cycle [GO:0046605]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of mRNA processing [GO:0050684]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q9UQ90	reviewed	SPG7_HUMAN	Paraplegin (EC 3.4.24.-) (Cell matrix adhesion regulator) (Spastic paraplegia 7 protein)	SPG7 CAR CMAR PGN	Homo sapiens (Human)	795	FUNCTION: ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (PubMed:26387735). {ECO:0000269|PubMed:26387735, ECO:0000305}.		anterograde axonal transport [GO:0008089]; mitochondrial outer membrane permeabilization involved in programmed cell death [GO:1902686]; mitochondrial protein processing [GO:0034982]; nervous system development [GO:0007399]; proteolysis [GO:0006508]; regulation of mitochondrial membrane permeability [GO:0046902]	axon cytoplasm [GO:1904115]; m-AAA complex [GO:0005745]; mitochondrial inner membrane [GO:0005743]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]	axon cytoplasm [GO:1904115]; m-AAA complex [GO:0005745]; mitochondrial inner membrane [GO:0005743]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]; anterograde axonal transport [GO:0008089]; mitochondrial outer membrane permeabilization involved in programmed cell death [GO:1902686]; mitochondrial protein processing [GO:0034982]; nervous system development [GO:0007399]; proteolysis [GO:0006508]; regulation of mitochondrial membrane permeability [GO:0046902]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:9635427}; Multi-pass membrane protein {ECO:0000255}.
Q9UQB3	reviewed	CTND2_HUMAN	Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin)	CTNND2 NPRAP	Homo sapiens (Human)	1225	FUNCTION: Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}.		cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; dendritic spine morphogenesis [GO:0060997]; regulation of canonical Wnt signaling pathway [GO:0060828]; signal transduction [GO:0007165]; synapse organization [GO:0050808]; Wnt signaling pathway [GO:0016055]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; dendritic spine morphogenesis [GO:0060997]; regulation of canonical Wnt signaling pathway [GO:0060828]; signal transduction [GO:0007165]; synapse organization [GO:0050808]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O35927}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O35927}. Cell projection, dendrite {ECO:0000250|UniProtKB:O35116}. Perikaryon {ECO:0000269|PubMed:22022388}.
Q9UQB8	reviewed	BAIP2_HUMAN	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)	BAIAP2	Homo sapiens (Human)	552	FUNCTION: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.		actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; axonogenesis [GO:0007409]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to L-glutamate [GO:1905232]; dendrite development [GO:0016358]; insulin receptor signaling pathway [GO:0008286]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; protein localization to synapse [GO:0035418]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of synaptic plasticity [GO:0048167]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine cytoplasm [GO:0061846]; excitatory synapse [GO:0060076]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; neuron projection branch point [GO:0061845]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density, intracellular component [GO:0099092]; presynaptic cytosol [GO:0099523]; ruffle [GO:0001726]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; synaptic membrane [GO:0097060]	cadherin binding involved in cell-cell adhesion [GO:0098641]; cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; proline-rich region binding [GO:0070064]; scaffold protein binding [GO:0097110]; transcription coregulator binding [GO:0001221]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine cytoplasm [GO:0061846]; excitatory synapse [GO:0060076]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; neuron projection branch point [GO:0061845]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density, intracellular component [GO:0099092]; presynaptic cytosol [GO:0099523]; ruffle [GO:0001726]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; synaptic membrane [GO:0097060]; cadherin binding involved in cell-cell adhesion [GO:0098641]; cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; proline-rich region binding [GO:0070064]; scaffold protein binding [GO:0097110]; transcription coregulator binding [GO:0001221]; actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; axonogenesis [GO:0007409]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to L-glutamate [GO:1905232]; dendrite development [GO:0016358]; insulin receptor signaling pathway [GO:0008286]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; protein localization to synapse [GO:0035418]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of synaptic plasticity [GO:0048167]	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
Q9UQB9	reviewed	AURKC_HUMAN	Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C)	AURKC AIE2 AIK3 AIRK3 ARK3 STK13	Homo sapiens (Human)	309	FUNCTION: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. {ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:15499654, ECO:0000269|PubMed:15670791, ECO:0000269|PubMed:15938719, ECO:0000269|PubMed:21493633, ECO:0000269|PubMed:21531210, ECO:0000269|PubMed:27332895}.		attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; histone modification [GO:0016570]; meiotic cell cycle [GO:0051321]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; positive regulation of cytokinesis [GO:0032467]; protein phosphorylation [GO:0006468]; regulation of cytokinesis [GO:0032465]	chromosome passenger complex [GO:0032133]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]; spindle pole centrosome [GO:0031616]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]	chromosome passenger complex [GO:0032133]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]; spindle pole centrosome [GO:0031616]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; histone modification [GO:0016570]; meiotic cell cycle [GO:0051321]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; positive regulation of cytokinesis [GO:0032467]; protein phosphorylation [GO:0006468]; regulation of cytokinesis [GO:0032465]	SUBCELLULAR LOCATION: Nucleus. Chromosome. Chromosome, centromere {ECO:0000269|PubMed:27332895}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15938719}. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. {ECO:0000269|PubMed:21531210}.
Q9UQC2	reviewed	GAB2_HUMAN	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)	GAB2 KIAA0571	Homo sapiens (Human)	676	FUNCTION: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.		osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mast cell degranulation [GO:0043306]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mast cell degranulation [GO:0043306]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19172738}. Cell membrane {ECO:0000269|PubMed:19172738}. Membrane raft {ECO:0000250|UniProtKB:Q9Z1S8}.
Q9UQC9	reviewed	CLCA2_HUMAN	Calcium-activated chloride channel regulator 2 (EC 3.4.-.-) (Calcium-activated chloride channel family member 2) (hCLCA2) (Calcium-activated chloride channel protein 3) (CaCC-3) (hCaCC-3) [Cleaved into: Calcium-activated chloride channel regulator 2, 109 kDa form; Calcium-activated chloride channel regulator 2, 35 kDa form]	CLCA2 CACC3	Homo sapiens (Human)	943	FUNCTION: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. {ECO:0000269|PubMed:10554024, ECO:0000269|PubMed:11320086, ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:15707651, ECO:0000269|PubMed:16158324}.		cell adhesion [GO:0007155]; monoatomic ion transmembrane transport [GO:0034220]; proteolysis [GO:0006508]	anchoring junction [GO:0070161]; basal plasma membrane [GO:0009925]; cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; ligand-gated monoatomic ion channel activity [GO:0015276]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	anchoring junction [GO:0070161]; basal plasma membrane [GO:0009925]; cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; ligand-gated monoatomic ion channel activity [GO:0015276]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; cell adhesion [GO:0007155]; monoatomic ion transmembrane transport [GO:0034220]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.; SUBCELLULAR LOCATION: [Calcium-activated chloride channel regulator 2, 109 kDa form]: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release.
Q9UQD0	reviewed	SCN8A_HUMAN	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)	SCN8A MED	Homo sapiens (Human)	1980	FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. {ECO:0000269|PubMed:19136557, ECO:0000269|PubMed:29726066, ECO:0000269|PubMed:33245860, ECO:0000269|PubMed:36696443, ECO:0000269|PubMed:36823201}.; FUNCTION: [Isoform 5]: In macrophages and melanoma cells, may participate in the control of podosome and invadopodia formation. {ECO:0000269|PubMed:29726066}.		calcium ion import across plasma membrane [GO:0098703]; myelination [GO:0042552]; nervous system development [GO:0007399]; neuronal action potential [GO:0019228]; optic nerve development [GO:0021554]; peripheral nervous system development [GO:0007422]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transport [GO:0006814]	axon [GO:0030424]; axon initial segment [GO:0043194]; cell junction [GO:0030054]; cytoplasmic vesicle [GO:0031410]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018]	ATP binding [GO:0005524]; high voltage-gated calcium channel activity [GO:0008331]; sodium ion binding [GO:0031402]; voltage-gated sodium channel activity [GO:0005248]	axon [GO:0030424]; axon initial segment [GO:0043194]; cell junction [GO:0030054]; cytoplasmic vesicle [GO:0031410]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018]; ATP binding [GO:0005524]; high voltage-gated calcium channel activity [GO:0008331]; sodium ion binding [GO:0031402]; voltage-gated sodium channel activity [GO:0005248]; calcium ion import across plasma membrane [GO:0098703]; myelination [GO:0042552]; nervous system development [GO:0007399]; neuronal action potential [GO:0019228]; optic nerve development [GO:0021554]; peripheral nervous system development [GO:0007422]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19136557}; Multi-pass membrane protein {ECO:0000269|PubMed:19136557}. Cell projection, axon {ECO:0000250|UniProtKB:Q9WTU3}. Note=Mainly localizes to the axon initial segment. {ECO:0000250|UniProtKB:Q9WTU3}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasmic vesicle. Note=Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane.
Q9UQE7	reviewed	SMC3_HUMAN	Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)	SMC3 BAM BMH CSPG6 SMC3L1	Homo sapiens (Human)	1217	FUNCTION: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}.	MISCELLANEOUS: Mutated Cornelia de Lange cell lines display genomic instability and sensitivity to ionizing radiation and interstrand cross-linking agents.	cell division [GO:0051301]; DNA repair [GO:0006281]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly [GO:0090307]; regulation of DNA replication [GO:0006275]; sister chromatid cohesion [GO:0007062]; stem cell population maintenance [GO:0019827]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; lateral element [GO:0000800]; meiotic cohesin complex [GO:0030893]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; cohesin loader activity [GO:0061775]; double-stranded DNA binding [GO:0003690]; dynein complex binding [GO:0070840]; mediator complex binding [GO:0036033]; microtubule motor activity [GO:0003777]; protein heterodimerization activity [GO:0046982]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; lateral element [GO:0000800]; meiotic cohesin complex [GO:0030893]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; cohesin loader activity [GO:0061775]; double-stranded DNA binding [GO:0003690]; dynein complex binding [GO:0070840]; mediator complex binding [GO:0036033]; microtubule motor activity [GO:0003777]; protein heterodimerization activity [GO:0046982]; cell division [GO:0051301]; DNA repair [GO:0006281]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly [GO:0090307]; regulation of DNA replication [GO:0006275]; sister chromatid cohesion [GO:0007062]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9CW03}. Chromosome {ECO:0000250|UniProtKB:Q9CW03}. Chromosome, centromere {ECO:0000250|UniProtKB:Q9CW03}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions (By similarity). {ECO:0000250|UniProtKB:Q9CW03}.
Q9UQF0	reviewed	SYCY1_HUMAN	Syncytin-1 (Endogenous retrovirus group W member 1) (Env-W) (Envelope polyprotein gPr73) (Enverin) (HERV-7q Envelope protein) (HERV-W envelope protein) (HERV-W_7q21.2 provirus ancestral Env polyprotein) (Syncytin) [Cleaved into: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)]	ERVW-1 ERVWE1	Homo sapiens (Human)	538	FUNCTION: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904). {ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:12050356, ECO:0000269|PubMed:23492904}.; FUNCTION: Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.	MISCELLANEOUS: Probably involved in the development of multiple sclerosis (MS). MS is a neurodegenerative disease characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. It leads to physical and cognitive disabilities. Viral particles or intracellular RNA of HERV-W family members have been detected in tissue from patients with multiple sclerosis or schizophrenia.; MISCELLANEOUS: Orthologs in P.troglodytes, G.gorilla, P.pygmaeus and H.moloch.; MISCELLANEOUS: It can make pseudotypes with HIV-1 virions and confer infectivity. Can also induce cellular resistance to spleen necrosis virus in vitro.; MISCELLANEOUS: HERV-W family subgenomic RNAs have been observed.; MISCELLANEOUS: This provirus is intergenic, the closest flanking genes being ODAG and PEX1.; MISCELLANEOUS: The human genome contains a high percentage of proviral-like elements, also called endogenous retroviruses (ERVs) that are the genomic traces of ancient infections of the germline by exogenous retroviruses. Although most of these elements are defective, some have conserved a functional envelope (env) gene, most probably diverted by the host for its benefit.	anatomical structure morphogenesis [GO:0009653]; myoblast fusion [GO:0007520]; syncytium formation [GO:0006949]; syncytium formation by plasma membrane fusion [GO:0000768]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; anatomical structure morphogenesis [GO:0009653]; myoblast fusion [GO:0007520]; syncytium formation [GO:0006949]; syncytium formation by plasma membrane fusion [GO:0000768]	SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000305|PubMed:15827173}; Peripheral membrane protein {ECO:0000305|PubMed:15827173}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000305|PubMed:15827173}.; SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Syncytin-1]: Virion {ECO:0000250}.
Q9UQF2	reviewed	JIP1_HUMAN	C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)	MAPK8IP1 IB1 JIP1 PRKM8IP	Homo sapiens (Human)	711	FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}.	MISCELLANEOUS: A chemically synthesized cell-permeable peptide of the minimal inhibitory domain decreases brain lesions in both transient and permanent ischemia. The level of protection is still high when administered 6 or 12 hours after ischemia.	JNK cascade [GO:0007254]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of JUN kinase activity [GO:0043508]; positive regulation of JNK cascade [GO:0046330]; regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000564]; regulation of DNA-templated transcription [GO:0006355]; regulation of JNK cascade [GO:0046328]; vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dentate gyrus mossy fiber [GO:0044302]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]	JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; protein kinase inhibitor activity [GO:0004860]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dentate gyrus mossy fiber [GO:0044302]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; protein kinase inhibitor activity [GO:0004860]; JNK cascade [GO:0007254]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of JUN kinase activity [GO:0043508]; positive regulation of JNK cascade [GO:0046330]; regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000564]; regulation of DNA-templated transcription [GO:0006355]; regulation of JNK cascade [GO:0046328]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). {ECO:0000250}.
Q9UQK1	reviewed	PPR3C_HUMAN	Protein phosphatase 1 regulatory subunit 3C (Protein phosphatase 1 regulatory subunit 5) (PP1 subunit R5) (Protein targeting to glycogen) (PTG)	PPP1R3C PPP1R5	Homo sapiens (Human)	317	FUNCTION: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. {ECO:0000250|UniProtKB:Q7TMB3, ECO:0000269|PubMed:8985175}.		glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; regulation of glycogen biosynthetic process [GO:0005979]	cytosol [GO:0005829]; protein phosphatase type 1 complex [GO:0000164]	glycogen binding [GO:2001069]; molecular adaptor activity [GO:0060090]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; protein phosphatase type 1 complex [GO:0000164]; glycogen binding [GO:2001069]; molecular adaptor activity [GO:0060090]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; regulation of glycogen biosynthetic process [GO:0005979]	
Q9UQL6	reviewed	HDAC5_HUMAN	Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)	HDAC5 KIAA0600	Homo sapiens (Human)	1122	FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}.		B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myotube differentiation [GO:0010830]; regulation of protein binding [GO:0043393]; response to activity [GO:0014823]; response to cocaine [GO:0042220]; response to xenobiotic stimulus [GO:0009410]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone deacetylase complex [GO:0000118]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor binding [GO:0001222]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone deacetylase complex [GO:0000118]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor binding [GO:0001222]; B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myotube differentiation [GO:0010830]; regulation of protein binding [GO:0043393]; response to activity [GO:0014823]; response to cocaine [GO:0042220]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
Q9UQM7	reviewed	KCC2A_HUMAN	Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)	CAMK2A CAMKA KIAA0968	Homo sapiens (Human)	478	FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}.		angiotensin-activated signaling pathway [GO:0038166]; calcium ion transport [GO:0006816]; cellular response to interferon-beta [GO:0035458]; cellular response to type II interferon [GO:0071346]; dendritic spine development [GO:0060996]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of hydrolase activity [GO:0051346]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine autophosphorylation [GO:1990443]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]; regulation of neuron migration [GO:2001222]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of neurotransmitter secretion [GO:0046928]; response to ischemia [GO:0002931]	calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; glutamate receptor binding [GO:0035254]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; glutamate receptor binding [GO:0035254]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; angiotensin-activated signaling pathway [GO:0038166]; calcium ion transport [GO:0006816]; cellular response to interferon-beta [GO:0035458]; cellular response to type II interferon [GO:0071346]; dendritic spine development [GO:0060996]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of hydrolase activity [GO:0051346]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine autophosphorylation [GO:1990443]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]; regulation of neuron migration [GO:2001222]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of neurotransmitter secretion [GO:0046928]; response to ischemia [GO:0002931]	SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:P11275}. Postsynaptic density {ECO:0000250|UniProtKB:P11275}. Cell projection, dendritic spine {ECO:0000269|PubMed:28130356}. Cell projection, dendrite {ECO:0000269|PubMed:28130356}. Note=Postsynaptic lipid rafts. {ECO:0000250|UniProtKB:P11275}.
Q9UQN3	reviewed	CHM2B_HUMAN	Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2)	CHMP2B CGI-84	Homo sapiens (Human)	213	FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.		autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cognition [GO:0050890]; endosome organization [GO:0007032]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; modulation of chemical synaptic transmission [GO:0050804]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; neuron cellular homeostasis [GO:0070050]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of postsynapse organization [GO:0099175]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	cadherin binding [GO:0045296]; protein domain specific binding [GO:0019904]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; cadherin binding [GO:0045296]; protein domain specific binding [GO:0019904]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cognition [GO:0050890]; endosome organization [GO:0007032]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; modulation of chemical synaptic transmission [GO:0050804]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; neuron cellular homeostasis [GO:0070050]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of postsynapse organization [GO:0099175]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16041373}. Late endosome membrane {ECO:0000305|PubMed:16041373}; Peripheral membrane protein {ECO:0000305|PubMed:16041373}.
Q9UQP3	reviewed	TENN_HUMAN	Tenascin-N (TN-N) (Tenascin-W) (TN-W)	TNN TNW	Homo sapiens (Human)	1299	FUNCTION: Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022). {ECO:0000250|UniProtKB:Q80YX1, ECO:0000250|UniProtKB:Q80Z71, ECO:0000269|PubMed:17909022, ECO:0000269|PubMed:19884327}.		axonogenesis [GO:0007409]; cell-matrix adhesion [GO:0007160]; dendrite self-avoidance [GO:0070593]; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation [GO:1905240]; negative regulation of neuron migration [GO:2001223]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; neuron projection extension [GO:1990138]; osteoblast development [GO:0002076]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of bone development [GO:1903010]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of smooth muscle tissue development [GO:1905899]	CA3 pyramidal cell dendrite [GO:0097442]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; hippocampal mossy fiber expansion [GO:1990026]; neuronal cell body [GO:0043025]; tenascin complex [GO:0090733]	identical protein binding [GO:0042802]; integrin binding [GO:0005178]	CA3 pyramidal cell dendrite [GO:0097442]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; hippocampal mossy fiber expansion [GO:1990026]; neuronal cell body [GO:0043025]; tenascin complex [GO:0090733]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; axonogenesis [GO:0007409]; cell-matrix adhesion [GO:0007160]; dendrite self-avoidance [GO:0070593]; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation [GO:1905240]; negative regulation of neuron migration [GO:2001223]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; neuron projection extension [GO:1990138]; osteoblast development [GO:0002076]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of bone development [GO:1903010]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of smooth muscle tissue development [GO:1905899]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:19884327}.
Q9UQQ1	reviewed	NALDL_HUMAN	Aminopeptidase NAALADL1 (EC 3.4.11.-) (100 kDa ileum brush border membrane protein) (I100) (Ileal dipeptidylpeptidase) (N-acetylated-alpha-linked acidic dipeptidase-like protein) (NAALADase L)	NAALADL1 NAALADASEL NAALADL	Homo sapiens (Human)	740	FUNCTION: Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position (PubMed:25752612). Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity (PubMed:25752612). {ECO:0000269|PubMed:25752612}.		peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]	aminopeptidase activity [GO:0004177]; calcium ion binding [GO:0005509]; carboxypeptidase activity [GO:0004180]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; aminopeptidase activity [GO:0004177]; calcium ion binding [GO:0005509]; carboxypeptidase activity [GO:0004180]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:O54697}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O54697}. Note=Ileal brush border membrane. {ECO:0000250|UniProtKB:O54697}.
Q9UQQ2	reviewed	SH2B3_HUMAN	SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)	SH2B3 LNK	Homo sapiens (Human)	575	FUNCTION: Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}.		cellular response to chemokine [GO:1990869]; cellular response to interleukin-3 [GO:0036016]; embryonic hemopoiesis [GO:0035162]; erythrocyte development [GO:0048821]; hematopoietic stem cell differentiation [GO:0060218]; intracellular signal transduction [GO:0035556]; megakaryocyte development [GO:0035855]; monocyte homeostasis [GO:0035702]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of Kit signaling pathway [GO:1900235]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; negative regulation of response to cytokine stimulus [GO:0060761]; neutrophil homeostasis [GO:0001780]; thrombopoietin-mediated signaling pathway [GO:0038163]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	protein tyrosine kinase binding [GO:1990782]; signaling receptor complex adaptor activity [GO:0030159]; stem cell factor receptor binding [GO:0005173]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein tyrosine kinase binding [GO:1990782]; signaling receptor complex adaptor activity [GO:0030159]; stem cell factor receptor binding [GO:0005173]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; cellular response to chemokine [GO:1990869]; cellular response to interleukin-3 [GO:0036016]; embryonic hemopoiesis [GO:0035162]; erythrocyte development [GO:0048821]; hematopoietic stem cell differentiation [GO:0060218]; intracellular signal transduction [GO:0035556]; megakaryocyte development [GO:0035855]; monocyte homeostasis [GO:0035702]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of Kit signaling pathway [GO:1900235]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; negative regulation of response to cytokine stimulus [GO:0060761]; neutrophil homeostasis [GO:0001780]; thrombopoietin-mediated signaling pathway [GO:0038163]	
Q9UQR0	reviewed	SCML2_HUMAN	Sex comb on midleg-like protein 2	SCML2	Homo sapiens (Human)	700	FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; negative regulation of DNA-templated transcription [GO:0045892]	nucleus [GO:0005634]; PcG protein complex [GO:0031519]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	nucleus [GO:0005634]; PcG protein complex [GO:0031519]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; anatomical structure morphogenesis [GO:0009653]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UQR1	reviewed	ZN148_HUMAN	Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89)	ZNF148 ZBP89	Homo sapiens (Human)	794	FUNCTION: Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.		cellular defense response [GO:0006968]; gamete generation [GO:0007276]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; substantia nigra development [GO:0021762]	Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; cellular defense response [GO:0006968]; gamete generation [GO:0007276]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Nucleus.
Q9UQV4	reviewed	LAMP3_HUMAN	Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (DC-lysosome-associated membrane glycoprotein) (DC LAMP) (Protein TSC403) (CD antigen CD208)	LAMP3 DCLAMP TSC403	Homo sapiens (Human)	416	FUNCTION: Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction (PubMed:25681212). Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process (PubMed:24434718). Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway (PubMed:29056532). May also play a role in dendritic cell function and in adaptive immunity (PubMed:9768752). {ECO:0000269|PubMed:24434718, ECO:0000269|PubMed:25681212, ECO:0000269|PubMed:29056532, ECO:0000269|PubMed:9768752}.; FUNCTION: (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection. {ECO:0000269|PubMed:21810281}.; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. {ECO:0000269|PubMed:32295904}.; FUNCTION: (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium. {ECO:0000269|PubMed:27329040}.		adaptive immune response [GO:0002250]; establishment of protein localization to organelle [GO:0072594]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of proteasomal protein catabolic process [GO:1901799]; positive regulation of gene expression [GO:0010628]; regulation of autophagy [GO:0010506]; regulation of viral life cycle [GO:1903900]; response to interferon-alpha [GO:0035455]	alveolar lamellar body membrane [GO:0097233]; cell surface [GO:0009986]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]		alveolar lamellar body membrane [GO:0097233]; cell surface [GO:0009986]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; adaptive immune response [GO:0002250]; establishment of protein localization to organelle [GO:0072594]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of proteasomal protein catabolic process [GO:1901799]; positive regulation of gene expression [GO:0010628]; regulation of autophagy [GO:0010506]; regulation of viral life cycle [GO:1903900]; response to interferon-alpha [GO:0035455]	SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:27329040}. Lysosome membrane {ECO:0000269|PubMed:21930964, ECO:0000269|PubMed:9768752}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9768752}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:21810281}; Single-pass type I membrane protein {ECO:0000255}. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752). Detected on lysosomes in mature dendritic cells (PubMed:9768752). {ECO:0000269|PubMed:9768752}.
Q9WJR5	reviewed	POK19_HUMAN	Endogenous retrovirus group K member 19 Pol protein (HERV-K(C19) Pol protein) (HERV-K_19q11 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]	ERVK-19	Homo sapiens (Human)	959	FUNCTION: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: Exact N-terminus of this protein has not been formally described.	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]		DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]	DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]	
Q9Y210	reviewed	TRPC6_HUMAN	Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6)	TRPC6 TRP6	Homo sapiens (Human)	931	FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346}.		calcium ion transmembrane transport [GO:0070588]; monoatomic cation transport [GO:0006812]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ion transmembrane transporter activity [GO:0032414]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338]	cation channel complex [GO:0034703]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057]	calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; monoatomic cation channel activity [GO:0005261]; protein homodimerization activity [GO:0042803]; store-operated calcium channel activity [GO:0015279]	cation channel complex [GO:0034703]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; monoatomic cation channel activity [GO:0005261]; protein homodimerization activity [GO:0042803]; store-operated calcium channel activity [GO:0015279]; calcium ion transmembrane transport [GO:0070588]; monoatomic cation transport [GO:0006812]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ion transmembrane transporter activity [GO:0032414]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346}; Multi-pass membrane protein {ECO:0000305}.
Q9Y215	reviewed	COLQ_HUMAN	Acetylcholinesterase collagenic tail peptide (AChE Q subunit) (Acetylcholinesterase-associated collagen)	COLQ	Homo sapiens (Human)	455	FUNCTION: Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.	MISCELLANEOUS: [Isoform VII]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	acetylcholine catabolic process in synaptic cleft [GO:0001507]; establishment of protein localization to membrane [GO:0090150]; extracellular matrix organization [GO:0030198]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]	basement membrane [GO:0005604]; cell junction [GO:0030054]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]	basement membrane [GO:0005604]; cell junction [GO:0030054]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; acetylcholine catabolic process in synaptic cleft [GO:0001507]; establishment of protein localization to membrane [GO:0090150]; extracellular matrix organization [GO:0030198]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]	SUBCELLULAR LOCATION: Synapse.
Q9Y216	reviewed	MTMR7_HUMAN	Myotubularin-related protein 7 (Inositol 1,3-bisphosphate phosphatase) (EC 3.1.3.-) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)	MTMR7	Homo sapiens (Human)	660	FUNCTION: Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2). {ECO:0000250|UniProtKB:Q9Z2C9}.		phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]	inositol bisphosphate phosphatase activity [GO:0016312]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate phosphatase activity [GO:0106018]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; inositol bisphosphate phosphatase activity [GO:0016312]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate phosphatase activity [GO:0106018]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein tyrosine phosphatase activity [GO:0004725]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16787938}. Endomembrane system {ECO:0000250|UniProtKB:Q9Z2C9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z2C9}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z2C9}. Note=May partially localize to endosomes and/or the Golgi apparatus. {ECO:0000250|UniProtKB:Q9Z2C9}.
Q9Y217	reviewed	MTMR6_HUMAN	Myotubularin-related protein 6 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)	MTMR6	Homo sapiens (Human)	621	FUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:19038970, PubMed:22647598). Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (PubMed:19038970, PubMed:22647598) (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). {ECO:0000250|UniProtKB:A0A0G2JXT6, ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:16847315, ECO:0000269|PubMed:19038970, ECO:0000269|PubMed:22647598, ECO:0000269|PubMed:24591580, ECO:0000305|PubMed:24591580}.		endocytosis [GO:0006897]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587]	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate phosphatase activity [GO:0106018]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate phosphatase activity [GO:0106018]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; endocytosis [GO:0006897]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19038970}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:19038970}. Endoplasmic reticulum {ECO:0000269|PubMed:19038970}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q8VE11}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19038970}. Note=Localizes to ruffles during EGF-induced macropinocytosis (By similarity). Colocalizes with MTMR9 to the perinuclear region (PubMed:19038970). Partially localizes to the endoplasmic reticulum (PubMed:19038970). Co-localizes with RAB1B to the endoplasmic reticulum-Golgi intermediate compartment and to the peri-Golgi region (By similarity). {ECO:0000250|UniProtKB:A0A0G2JXT6, ECO:0000250|UniProtKB:Q8VE11, ECO:0000269|PubMed:19038970}.
Q9Y219	reviewed	JAG2_HUMAN	Protein jagged-2 (Jagged2) (hJ2)	JAG2	Homo sapiens (Human)	1238	FUNCTION: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). {ECO:0000250}.		auditory receptor cell fate commitment [GO:0009912]; cell differentiation [GO:0030154]; epithelial cell apoptotic process involved in palatal shelf morphogenesis [GO:1990134]; gamma-delta T cell differentiation [GO:0042492]; in utero embryonic development [GO:0001701]; morphogenesis of embryonic epithelium [GO:0016331]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; respiratory system process [GO:0003016]; skeletal system development [GO:0001501]; spermatogenesis [GO:0007283]; T cell differentiation [GO:0030217]; thymic T cell selection [GO:0045061]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; Notch binding [GO:0005112]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; Notch binding [GO:0005112]; auditory receptor cell fate commitment [GO:0009912]; cell differentiation [GO:0030154]; epithelial cell apoptotic process involved in palatal shelf morphogenesis [GO:1990134]; gamma-delta T cell differentiation [GO:0042492]; in utero embryonic development [GO:0001701]; morphogenesis of embryonic epithelium [GO:0016331]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; respiratory system process [GO:0003016]; skeletal system development [GO:0001501]; spermatogenesis [GO:0007283]; T cell differentiation [GO:0030217]; thymic T cell selection [GO:0045061]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9Y221	reviewed	NIP7_HUMAN	60S ribosome subunit biogenesis protein NIP7 homolog (KD93) (Nucleolar pre-rRNA processing protein NIP7)	NIP7 CGI-37 HSPC031 HSPC180 OK/SW-cl.76 OK/SW-cl.78	Homo sapiens (Human)	180	FUNCTION: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly. {ECO:0000269|PubMed:22195017}.		ribosomal large subunit biogenesis [GO:0042273]; ribosome assembly [GO:0042255]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]	RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]; RNA binding [GO:0003723]; ribosomal large subunit biogenesis [GO:0042273]; ribosome assembly [GO:0042255]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:22195017}.
Q9Y222	reviewed	DMTF1_HUMAN	Cyclin-D-binding Myb-like transcription factor 1 (hDMTF1) (Cyclin-D-interacting Myb-like protein 1) (hDMP1)	DMTF1 DMP1	Homo sapiens (Human)	760	FUNCTION: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. {ECO:0000250, ECO:0000269|PubMed:12917399}.		cell cycle [GO:0007049]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell cycle [GO:0007049]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:17936562}.
Q9Y223	reviewed	GLCNE_HUMAN	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc-2-epimerase/ManAc kinase) [Includes: UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC 3.2.1.183) (UDP-GlcNAc-2-epimerase) (Uridine diphosphate-N-acetylglucosamine-2-epimerase); N-acetylmannosamine kinase (EC 2.7.1.60) (ManAc kinase)]	GNE GLCNE	Homo sapiens (Human)	722	FUNCTION: Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. {ECO:0000250, ECO:0000269|PubMed:10334995}.		cell adhesion [GO:0007155]; N-acetylglucosamine biosynthetic process [GO:0006045]; N-acetylneuraminate metabolic process [GO:0006054]; UDP-N-acetylglucosamine metabolic process [GO:0006047]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; metal ion binding [GO:0046872]; N-acylmannosamine kinase activity [GO:0009384]; UDP-N-acetylglucosamine 2-epimerase activity [GO:0008761]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; metal ion binding [GO:0046872]; N-acylmannosamine kinase activity [GO:0009384]; UDP-N-acetylglucosamine 2-epimerase activity [GO:0008761]; cell adhesion [GO:0007155]; N-acetylglucosamine biosynthetic process [GO:0006045]; N-acetylneuraminate metabolic process [GO:0006054]; UDP-N-acetylglucosamine metabolic process [GO:0006047]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9Y224	reviewed	RTRAF_HUMAN	RNA transcription, translation and transport factor protein (CLE7 homolog) (CLE) (hCLE)	RTRAF C14orf166 CGI-99	Homo sapiens (Human)	244	FUNCTION: RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264). {ECO:0000269|PubMed:16950395, ECO:0000269|PubMed:24608264, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157). {ECO:0000269|PubMed:21900157}.		negative regulation of protein kinase activity [GO:0006469]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA transport [GO:0050658]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; tRNA-splicing ligase complex [GO:0072669]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; tRNA-splicing ligase complex [GO:0072669]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA transport [GO:0050658]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}. Cytoplasm, cytosol {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15147888}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15147888}. Note=May localize at the centrosome during mitosis (PubMed:15147888). Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26864902}. Cytoplasm {ECO:0000269|PubMed:26864902}. Note=(Microbial infection) Following influenza A virus (IAV) infection, included in influenza A virions via its association with packaged viral ribonucleoproteins (vRNP) in the nucleus and cytoplasm (PubMed:21900157, PubMed:26864902). {ECO:0000269|PubMed:21900157, ECO:0000269|PubMed:26864902}.
Q9Y225	reviewed	RNF24_HUMAN	RING finger protein 24	RNF24	Homo sapiens (Human)	148	FUNCTION: May play a role in TRPCs intracellular trafficking. {ECO:0000269|PubMed:17850865}.			Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	zinc ion binding [GO:0008270]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17850865}; Single-pass membrane protein {ECO:0000269|PubMed:17850865}.
Q9Y226	reviewed	S22AD_HUMAN	Solute carrier family 22 member 13 (Organic anion transporter 10) (OAT10) (Organic cation transporter-like 3) (ORCTL-3) (ORCTL3)	SLC22A13 OCTL1 ORCTL3	Homo sapiens (Human)	551	FUNCTION: Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions (PubMed:18411268, PubMed:35144162, PubMed:31780526, PubMed:35462902). Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption (PubMed:18411268, PubMed:35144162, PubMed:31780526). Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption (PubMed:18411268, PubMed:35144162). Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate (PubMed:18411268). Urate and orotate transports are Cl(-)-dependent (PubMed:35144162, PubMed:35462902). Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable). {ECO:0000269|PubMed:18411268, ECO:0000269|PubMed:31780526, ECO:0000269|PubMed:35144162, ECO:0000269|PubMed:35462902, ECO:0000305|PubMed:35144162, ECO:0000305|PubMed:35462902}.		NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of fatty acid metabolic process [GO:0045922]; nicotinate transport [GO:2001142]; positive regulation of T cell mediated cytotoxicity directed against tumor cell target [GO:0002854]; urate transport [GO:0015747]	apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	nicotinate transmembrane transporter activity [GO:0090416]; urate transmembrane transporter activity [GO:0015143]	apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; nicotinate transmembrane transporter activity [GO:0090416]; urate transmembrane transporter activity [GO:0015143]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of fatty acid metabolic process [GO:0045922]; nicotinate transport [GO:2001142]; positive regulation of T cell mediated cytotoxicity directed against tumor cell target [GO:0002854]; urate transport [GO:0015747]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:18411268, ECO:0000269|PubMed:31780526, ECO:0000269|PubMed:35144162, ECO:0000269|PubMed:35462902}; Multi-pass membrane protein {ECO:0000305}.
Q9Y227	reviewed	ENTP4_HUMAN	Ectonucleoside triphosphate diphosphohydrolase 4 (NTPDase 4) (EC 3.6.1.15) (EC 3.6.1.6) (Golgi UDPase) (Lysosomal apyrase-like protein of 70 kDa) (Uridine-diphosphatase) (UDPase) (EC 3.6.1.42)	ENTPD4 KIAA0392 LALP70 LYSAL1	Homo sapiens (Human)	616	FUNCTION: [Isoform 1]: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates (PubMed:10858452, PubMed:9556635). Preferentially activated by Ca(2+) over Mg(2+) (PubMed:10858452). {ECO:0000269|PubMed:10858452, ECO:0000269|PubMed:9556635}.; FUNCTION: [Isoform 2]: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally. {ECO:0000269|PubMed:10858452, ECO:0000269|PubMed:9556635}.		CTP metabolic process [GO:0046036]; GDP catabolic process [GO:0046712]; nucleobase-containing small molecule catabolic process [GO:0034656]; UDP catabolic process [GO:0006256]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]	CDP phosphatase activity [GO:0036384]; CTPase activity [GO:0043273]; GDP phosphatase activity [GO:0004382]; GTPase activity [GO:0003924]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; CDP phosphatase activity [GO:0036384]; CTPase activity [GO:0043273]; GDP phosphatase activity [GO:0004382]; GTPase activity [GO:0003924]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]; CTP metabolic process [GO:0046036]; GDP catabolic process [GO:0046712]; nucleobase-containing small molecule catabolic process [GO:0034656]; UDP catabolic process [GO:0006256]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:10393803}; Multi-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:10393803}; Multi-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane {ECO:0000269|PubMed:9556635}; Multi-pass membrane protein {ECO:0000255}.
Q9Y228	reviewed	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3)	TRAF3IP3 T3JAM	Homo sapiens (Human)	551	FUNCTION: Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (PubMed:32366851). {ECO:0000269|PubMed:26195727, ECO:0000269|PubMed:30115741, ECO:0000269|PubMed:30573680, ECO:0000269|PubMed:31390091, ECO:0000269|PubMed:32366851}.		positive regulation of type I interferon production [GO:0032481]	Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	molecular adaptor activity [GO:0060090]	Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; molecular adaptor activity [GO:0060090]; positive regulation of type I interferon production [GO:0032481]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30573680}. Golgi apparatus membrane {ECO:0000269|PubMed:26195727}; Single-pass type IV membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000250|UniProtKB:Q8C0G2}. Mitochondrion outer membrane {ECO:0000269|PubMed:31390091}. Note=Accumulates on the mitochondria after virus infection. {ECO:0000269|PubMed:31390091}.
Q9Y230	reviewed	RUVB2_HUMAN	RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)	RUVBL2 INO80J TIP48 TIP49B CGI-46	Homo sapiens (Human)	463	FUNCTION: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:10428817, ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11713276, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:25652260, ECO:0000269|PubMed:28561026, ECO:0000269|PubMed:33205750}.		box C/D snoRNP assembly [GO:0000492]; cellular response to estradiol stimulus [GO:0071392]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; telomere maintenance [GO:0000723]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; Ino80 complex [GO:0031011]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; DNA helicase activity [GO:0003678]; identical protein binding [GO:0042802]; promoter-enhancer loop anchoring activity [GO:0140585]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription corepressor activity [GO:0003714]; unfolded protein binding [GO:0051082]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; Ino80 complex [GO:0031011]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; DNA helicase activity [GO:0003678]; identical protein binding [GO:0042802]; promoter-enhancer loop anchoring activity [GO:0140585]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription corepressor activity [GO:0003714]; unfolded protein binding [GO:0051082]; box C/D snoRNP assembly [GO:0000492]; cellular response to estradiol stimulus [GO:0071392]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Dynein axonemal particle {ECO:0000250|UniProtKB:Q9DE27}. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes.
Q9Y231	reviewed	FUT9_HUMAN	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (EC 2.4.1.152) (Fucosyltransferase 9) (Fucosyltransferase IX) (Fuc-TIX) (FucT-IX) (Galactoside 3-L-fucosyltransferase)	FUT9	Homo sapiens (Human)	359	FUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth (PubMed:23263199, PubMed:23192350, PubMed:10386598, PubMed:17335083, PubMed:23000574, PubMed:11278338, PubMed:10622713, PubMed:18395013, PubMed:12107078, PubMed:16282604, PubMed:29593094). Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lactosamine unit of the alpha2,3-sialylated polylactosamine resulting in sLex (CD15s) epitope synthesis (PubMed:12107078, PubMed:18395013). Furthermore, it is capable of synthesizing Lewis a (Lea), although to a lesser extent than Lex and Lewis y (Ley) and to confer SELE-dependent, but not SELL- and SELP-selectin-dependent, cell rolling and adhesion by enhancing Lex and sLex synthesis (PubMed:18395013, PubMed:23192350). May also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE. {ECO:0000269|PubMed:10386598, ECO:0000269|PubMed:10622713, ECO:0000269|PubMed:11278338, ECO:0000269|PubMed:12107078, ECO:0000269|PubMed:16282604, ECO:0000269|PubMed:17335083, ECO:0000269|PubMed:18395013, ECO:0000269|PubMed:23000574, ECO:0000269|PubMed:23192350, ECO:0000269|PubMed:23263199}.		carbohydrate metabolic process [GO:0005975]; fucosylation [GO:0036065]; glycosphingolipid biosynthetic process [GO:0006688]; L-fucose catabolic process [GO:0042355]; N-glycan fucosylation [GO:0036071]; neuron differentiation [GO:0030182]; oligosaccharide biosynthetic process [GO:0009312]; polysaccharide biosynthetic process [GO:0000271]; positive regulation of neuron projection development [GO:0010976]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; regulation of leukocyte cell-cell adhesion [GO:1903037]; regulation of leukocyte tethering or rolling [GO:1903236]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417]; carbohydrate metabolic process [GO:0005975]; fucosylation [GO:0036065]; glycosphingolipid biosynthetic process [GO:0006688]; L-fucose catabolic process [GO:0042355]; N-glycan fucosylation [GO:0036071]; neuron differentiation [GO:0030182]; oligosaccharide biosynthetic process [GO:0009312]; polysaccharide biosynthetic process [GO:0000271]; positive regulation of neuron projection development [GO:0010976]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; regulation of leukocyte cell-cell adhesion [GO:1903037]; regulation of leukocyte tethering or rolling [GO:1903236]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18395013}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6P4F1}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O88819}.
Q9Y232	reviewed	CDYL_HUMAN	Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-)	CDYL CDYL1	Homo sapiens (Human)	598	FUNCTION: [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). {ECO:0000250|UniProtKB:Q9WTK2, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:22009739, ECO:0000269|PubMed:28402439, ECO:0000269|PubMed:28803779, ECO:0000269|PubMed:29177481}.; FUNCTION: [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain (PubMed:19808672). {ECO:0000269|PubMed:19808672}.; FUNCTION: [Isoform 3]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672). Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin. {ECO:0000269|PubMed:19808672}.	MISCELLANEOUS: [Isoform 2]: Major isoform. {ECO:0000269|PubMed:19808672}.	negative regulation of peptidyl-lysine crotonylation [GO:0120094]; random inactivation of X chromosome [GO:0060816]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; crotonyl-CoA hydratase activity [GO:0120092]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; protein-macromolecule adaptor activity [GO:0030674]; transcription corepressor activity [GO:0003714]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; crotonyl-CoA hydratase activity [GO:0120092]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; protein-macromolecule adaptor activity [GO:0030674]; transcription corepressor activity [GO:0003714]; negative regulation of peptidyl-lysine crotonylation [GO:0120094]; random inactivation of X chromosome [GO:0060816]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:18450745, ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:29177481}. Chromosome {ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:29177481}. Note=Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:19808672). Multimerization is required for chromatin-binding (PubMed:19808672). Recruited to sites of DNA double strand breaks in a PARP1-dependent fashion (PubMed:29177481). {ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:29177481}.
Q9Y233	reviewed	PDE10_HUMAN	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17)	PDE10A	Homo sapiens (Human)	779	FUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10373451, PubMed:10393245, PubMed:16330539, PubMed:27058447, PubMed:17389385). Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:27058447, PubMed:17389385). May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447). {ECO:0000269|PubMed:10373451, ECO:0000269|PubMed:10393245, ECO:0000269|PubMed:16330539, ECO:0000269|PubMed:17389385, ECO:0000269|PubMed:27058447}.		cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; negative regulation of cGMP-mediated signaling [GO:0010754]; signal transduction [GO:0007165]	cytosol [GO:0005829]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; metal ion binding [GO:0046872]; cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; negative regulation of cGMP-mediated signaling [GO:0010754]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10373451, ECO:0000269|PubMed:10441464}.
Q9Y234	reviewed	LIPT_HUMAN	Lipoyltransferase 1, mitochondrial (EC 2.3.1.-) (Lipoate biosynthesis protein) (Lipoate-protein ligase) (Lipoyl ligase)	LIPT1	Homo sapiens (Human)	373	FUNCTION: Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes. {ECO:0000250}.		carboxylic acid metabolic process [GO:0019752]; lipid metabolic process [GO:0006629]; protein modification process [GO:0036211]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	acyltransferase activity [GO:0016746]; lipoyltransferase activity [GO:0017118]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; acyltransferase activity [GO:0016746]; lipoyltransferase activity [GO:0017118]; carboxylic acid metabolic process [GO:0019752]; lipid metabolic process [GO:0006629]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Mitochondrion.
Q9Y235	reviewed	ABEC2_HUMAN	C->U-editing enzyme APOBEC-2 (EC 3.5.4.36) (mRNA(cytosine(6666)) deaminase 2)	APOBEC2	Homo sapiens (Human)	224	FUNCTION: Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:17187054, ECO:0000269|PubMed:21496894}.		cytidine to uridine editing [GO:0016554]; DNA demethylation [GO:0080111]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	cytidine deaminase activity [GO:0004126]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; cytidine deaminase activity [GO:0004126]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; cytidine to uridine editing [GO:0016554]; DNA demethylation [GO:0080111]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]	
Q9Y237	reviewed	PIN4_HUMAN	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (hPar14) (Parvulin-17) (Par17) (hPar17) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Peptidyl-prolyl cis/trans isomerase EPVH) (hEPVH) (Rotamase Pin4)	PIN4	Homo sapiens (Human)	131	FUNCTION: Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. {ECO:0000269|PubMed:19369196}.; FUNCTION: Isoform 2 binds to double-stranded DNA. {ECO:0000269|PubMed:19369196}.	MISCELLANEOUS: [Isoform 2]: The first 25 amino acids are sufficient for mitochondrial targeting. {ECO:0000305}.	localization [GO:0051179]; rRNA processing [GO:0006364]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome [GO:0030684]; spindle [GO:0005819]	bent DNA binding [GO:0003681]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome [GO:0030684]; spindle [GO:0005819]; bent DNA binding [GO:0003681]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; localization [GO:0051179]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N-terminal domain that functions as non-cleavable mitochondrial targeting peptide.
Q9Y238	reviewed	DLEC1_HUMAN	Deleted in lung and esophageal cancer protein 1 (Deleted in lung cancer protein 1) (DLC-1)	DLEC1 DLC1	Homo sapiens (Human)	1755	FUNCTION: Essential for spermatogenesis and male fertility (By similarity). May play an important role in sperm head and tail formation (By similarity). May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000250|UniProtKB:Q8BLA1, ECO:0000269|PubMed:10213508}.	MISCELLANEOUS: [Isoform 2]: Levels of this splice isoform may be increased in cancer cell lines and primary cancers. {ECO:0000303|PubMed:10213508, ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Levels of this splice isoform are increased in cancer cell lines and primary cancers. {ECO:0000269|PubMed:10213508}.	cell differentiation [GO:0030154]; defense response to tumor cell [GO:0002357]; negative regulation of cell population proliferation [GO:0008285]; spermatogenesis [GO:0007283]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; tubulin binding [GO:0015631]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; tubulin binding [GO:0015631]; cell differentiation [GO:0030154]; defense response to tumor cell [GO:0002357]; negative regulation of cell population proliferation [GO:0008285]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10213508, ECO:0000269|PubMed:33144677}.
Q9Y239	reviewed	NOD1_HUMAN	Nucleotide-binding oligomerization domain-containing protein 1 (hNod1) (Caspase recruitment domain-containing protein 4)	NOD1 CARD4	Homo sapiens (Human)	953	FUNCTION: Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and thus participates in both innate and adaptive immune responses (PubMed:11058605, PubMed:12796777, PubMed:12791997, PubMed:15044951, PubMed:16172124, PubMed:19043560, PubMed:22672233, PubMed:27099311). Specifically recognizes and binds gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), a dipeptide present in peptidoglycan of Gram-negative bacteria (PubMed:12871942, PubMed:12796777, PubMed:12791997, PubMed:16211083, PubMed:16172124). Preferentially binds iE-DAP in tripeptide-containing muropeptides (MurNAc-TriDAP or TriDAP) (PubMed:16211083). Ligand binding triggers oligomerization that facilitates the binding and subsequent activation of the proximal adapter receptor-interacting RIPK2 (PubMed:12796777, PubMed:12791997, PubMed:17054981). Following recruitment, RIPK2 undergoes 'Met-1'- (linear) and 'Lys-63'-linked polyubiquitination by E3 ubiquitin-protein ligases XIAP, BIRC2, BIRC3 and the LUBAC complex, becoming a scaffolding protein for downstream effectors, triggering activation of the NF-kappa-B and MAP kinases signaling (PubMed:10880512, PubMed:12791997, PubMed:19043560). This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (PubMed:10880512, PubMed:19043560). Also acts as a regulator of antiviral response elicited by dsRNA and the expression of RLR pathway members by targeting IFIH1 and TRAF3 to modulate the formation of IFIH1-MAVS and TRAF3-MAVS complexes leading to increased transcription of type I IFNs (PubMed:32169843). Also acts as a regulator of autophagy via its interaction with ATG16L1, possibly by recruiting ATG16L1 at the site of bacterial entry (By similarity). Besides recognizing pathogens, also involved in the endoplasmic reticulum stress response: acts by sensing and binding to the cytosolic metabolite sphingosine-1-phosphate generated in response to endoplasmic reticulum stress, initiating an inflammation process that leads to activation of the NF-kappa-B and MAP kinases signaling (PubMed:27007849, PubMed:33942347). In addition, plays a role in insulin trafficking in beta cells in a cell-autonomous manner (By similarity). Mechanistically, upon recognizing cognate ligands, NOD1 and RIPK2 localize to insulin vesicles where they recruit RAB1A to direct insulin trafficking through the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q8BHB0, ECO:0000269|PubMed:10880512, ECO:0000269|PubMed:11058605, ECO:0000269|PubMed:12791997, ECO:0000269|PubMed:12796777, ECO:0000269|PubMed:12871942, ECO:0000269|PubMed:15044951, ECO:0000269|PubMed:16172124, ECO:0000269|PubMed:16211083, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:22672233, ECO:0000269|PubMed:27007849, ECO:0000269|PubMed:27099311, ECO:0000269|PubMed:32169843, ECO:0000269|PubMed:33942347}.; FUNCTION: [Isoform 3]: In contrast to isoform 1, does not efficiently recognize and bind gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) ligand. {ECO:0000269|PubMed:16172124}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to muramyl dipeptide [GO:0071225]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; detection of biotic stimulus [GO:0009595]; ERK1 and ERK2 cascade [GO:0070371]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of xenophagy [GO:1904417]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; xenophagy [GO:0098792]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; CARD domain binding [GO:0050700]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; peptide receptor activity [GO:0001653]; peptidoglycan binding [GO:0042834]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; CARD domain binding [GO:0050700]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; peptide receptor activity [GO:0001653]; peptidoglycan binding [GO:0042834]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to muramyl dipeptide [GO:0071225]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; detection of biotic stimulus [GO:0009595]; ERK1 and ERK2 cascade [GO:0070371]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of xenophagy [GO:1904417]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; xenophagy [GO:0098792]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31649195}; Lipid-anchor {ECO:0000269|PubMed:31649195}. Apical cell membrane {ECO:0000269|PubMed:19043560}. Basolateral cell membrane {ECO:0000269|PubMed:19043560}. Cytoplasm {ECO:0000269|PubMed:10329646, ECO:0000269|PubMed:31649195}. Note=Detected in the cytoplasm and at the cell membrane (PubMed:31649195). Following bacterial infection, localizes to bacterial entry sites in the cell membrane (PubMed:31649195). Recruited to the basolateral and apical membranes in polarized epithelial cells (PubMed:19043560). {ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:31649195}.
Q9Y240	reviewed	CLC11_HUMAN	C-type lectin domain family 11 member A (C-type lectin superfamily member 3) (Lymphocyte secreted C-type lectin) (Osteolectin) (Stem cell growth factor) (p47)	CLEC11A CLECSF3 LSLCL SCGF	Homo sapiens (Human)	323	FUNCTION: Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed:27976999). Important for repair and maintenance of adult bone (By similarity). {ECO:0000250|UniProtKB:O88200, ECO:0000269|PubMed:27976999}.		ossification [GO:0001503]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	carbohydrate binding [GO:0030246]; growth factor activity [GO:0008083]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; carbohydrate binding [GO:0030246]; growth factor activity [GO:0008083]; ossification [GO:0001503]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11803813}. Secreted {ECO:0000269|PubMed:11803813, ECO:0000269|PubMed:9442024}.
Q9Y241	reviewed	HIG1A_HUMAN	HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) (RCF1 homolog A) (RCF1a)	HIGD1A HIG1 HSPC010	Homo sapiens (Human)	93	FUNCTION: Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269|PubMed:22342701}.		mitochondrial respirasome assembly [GO:0097250]; negative regulation of apoptotic process [GO:0043066]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; respirasome [GO:0070469]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; respirasome [GO:0070469]; mitochondrial respirasome assembly [GO:0097250]; negative regulation of apoptotic process [GO:0043066]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000255|PROSITE-ProRule:PRU00836, ECO:0000269|PubMed:22342701}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00836, ECO:0000269|PubMed:22342701}. Mitochondrion inner membrane {ECO:0000305|PubMed:22342701}.
Q9Y242	reviewed	TCF19_HUMAN	Transcription factor 19 (TCF-19) (Transcription factor SC1)	TCF19 SC1	Homo sapiens (Human)	345	FUNCTION: Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.		regulation of gene expression [GO:0010468]	nucleus [GO:0005634]	metal ion binding [GO:0046872]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y243	reviewed	AKT3_HUMAN	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)	AKT3 PKBG	Homo sapiens (Human)	479	FUNCTION: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}.		brain morphogenesis [GO:0048854]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular signal transduction [GO:0035556]; mitochondrial genome maintenance [GO:0000002]; negative regulation of cellular senescence [GO:2000773]; positive regulation of angiogenesis [GO:0045766]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell size [GO:0045793]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of TOR signaling [GO:0032008]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; brain morphogenesis [GO:0048854]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular signal transduction [GO:0035556]; mitochondrial genome maintenance [GO:0000002]; negative regulation of cellular senescence [GO:2000773]; positive regulation of angiogenesis [GO:0045766]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell size [GO:0045793]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of TOR signaling [GO:0032008]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20018949}. Cytoplasm {ECO:0000269|PubMed:20018949}. Membrane {ECO:0000269|PubMed:20018949}; Peripheral membrane protein {ECO:0000269|PubMed:20018949}. Note=Membrane-associated after cell stimulation leading to its translocation.
Q9Y244	reviewed	POMP_HUMAN	Proteasome maturation protein (Proteassemblin) (Protein UMP1 homolog) (hUMP1) (Voltage-gated K channel beta subunit 4.1)	POMP C13orf12 UMP1 HSPC014 HSPC036 PNAS-110	Homo sapiens (Human)	141	FUNCTION: Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum. {ECO:0000269|PubMed:15944226, ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17948026}.		proteasome assembly [GO:0043248]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; proteasome assembly [GO:0043248]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Microsome membrane.
Q9Y247	reviewed	FA50B_HUMAN	Protein FAM50B (Protein XAP-5-like)	FAM50B X5L	Homo sapiens (Human)	325			chromatin organization [GO:0006325]	intercellular bridge [GO:0045171]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		intercellular bridge [GO:0045171]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin organization [GO:0006325]	
Q9Y248	reviewed	PSF2_HUMAN	DNA replication complex GINS protein PSF2 (GINS complex subunit 2)	GINS2 PSF2 CGI-122 DC5 HSPC037	Homo sapiens (Human)	185	FUNCTION: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). {ECO:0000269|PubMed:17417653, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}.		DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]	CMG complex [GO:0071162]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		CMG complex [GO:0071162]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associates with chromatin. {ECO:0000305|PubMed:35585232}.
Q9Y250	reviewed	LZTS1_HUMAN	Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)	LZTS1 FEZ1	Homo sapiens (Human)	596	FUNCTION: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}.	MISCELLANEOUS: Defects in LZTS1 are found in many types of tumors.	cell cycle [GO:0007049]; negative regulation of macroautophagy [GO:0016242]; regulation of dendrite morphogenesis [GO:0048814]; regulation of postsynapse assembly [GO:0150052]; regulation of synaptic plasticity [GO:0048167]	cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]		cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; cell cycle [GO:0007049]; negative regulation of macroautophagy [GO:0016242]; regulation of dendrite morphogenesis [GO:0048814]; regulation of postsynapse assembly [GO:0150052]; regulation of synaptic plasticity [GO:0048167]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}.
Q9Y251	reviewed	HPSE_HUMAN	Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]	HPSE HEP HPA HPA1 HPR1 HPSE1 HSE1	Homo sapiens (Human)	543	FUNCTION: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis. {ECO:0000269|PubMed:12213822, ECO:0000269|PubMed:12773484, ECO:0000269|PubMed:15044433, ECO:0000269|PubMed:16452201, ECO:0000269|PubMed:18557927, ECO:0000269|PubMed:18798279, ECO:0000269|PubMed:19244131, ECO:0000269|PubMed:20097882, ECO:0000269|PubMed:20181948, ECO:0000269|PubMed:20309870, ECO:0000269|PubMed:20561914, ECO:0000269|PubMed:21131364}.	MISCELLANEOUS: [Isoform 2]: Escapes proteolytic cleavage, devoid of HS degradation activity. {ECO:0000305}.	angiogenesis involved in wound healing [GO:0060055]; cell-matrix adhesion [GO:0007160]; establishment of endothelial barrier [GO:0061028]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparin metabolic process [GO:0030202]; positive regulation of blood coagulation [GO:0030194]; positive regulation of hair follicle development [GO:0051798]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein transmembrane transport [GO:0071806]; proteoglycan metabolic process [GO:0006029]; regulation of hair follicle development [GO:0051797]; response to organic substance [GO:0010033]; vascular wound healing [GO:0061042]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]	beta-glucuronidase activity [GO:0004566]; heparanase activity [GO:0030305]; syndecan binding [GO:0045545]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]; beta-glucuronidase activity [GO:0004566]; heparanase activity [GO:0030305]; syndecan binding [GO:0045545]; angiogenesis involved in wound healing [GO:0060055]; cell-matrix adhesion [GO:0007160]; establishment of endothelial barrier [GO:0061028]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparin metabolic process [GO:0030202]; positive regulation of blood coagulation [GO:0030194]; positive regulation of hair follicle development [GO:0051798]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein transmembrane transport [GO:0071806]; proteoglycan metabolic process [GO:0006029]; regulation of hair follicle development [GO:0051797]; response to organic substance [GO:0010033]; vascular wound healing [GO:0061042]	SUBCELLULAR LOCATION: Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). {ECO:0000250}.
Q9Y252	reviewed	RNF6_HUMAN	E3 ubiquitin-protein ligase RNF6 (EC 2.3.2.27)	RNF6 SPG2	Homo sapiens (Human)	685	FUNCTION: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation (By similarity). Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover (By similarity). Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity (PubMed:19345326). May also bind DNA and function as a transcriptional regulator (By similarity). Mediates polyubiquitination of QKI in macrophages, leading to its degradation (By similarity). {ECO:0000250|UniProtKB:Q9DBU5, ECO:0000269|PubMed:19345326}.		axon extension [GO:0048675]; negative regulation of axon extension [GO:0030517]; positive regulation of DNA-templated transcription [GO:0045893]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of DNA-templated transcription [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511]	axon [GO:0030424]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	axon [GO:0030424]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; axon extension [GO:0048675]; negative regulation of axon extension [GO:0030517]; positive regulation of DNA-templated transcription [GO:0045893]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of DNA-templated transcription [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19345326}. Cytoplasm {ECO:0000269|PubMed:19345326}. Cell projection, axon {ECO:0000250|UniProtKB:Q9DBU5}. Nucleus, PML body {ECO:0000250|UniProtKB:Q9DBU5}. Note=Localizes to the PML nuclear bodies in Sertoli cells. {ECO:0000250|UniProtKB:Q9DBU5}.
Q9Y253	reviewed	POLH_HUMAN	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein)	POLH RAD30 RAD30A XPV	Homo sapiens (Human)	713	FUNCTION: DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906, PubMed:24553286, PubMed:16357261). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). {ECO:0000269|PubMed:10385124, ECO:0000269|PubMed:11376341, ECO:0000269|PubMed:11743006, ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:14734526, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:24553286}.		cellular response to UV-C [GO:0071494]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; pyrimidine dimer repair [GO:0006290]; regulation of DNA repair [GO:0006282]; response to radiation [GO:0009314]; response to UV-C [GO:0010225]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]	damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]; damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; cellular response to UV-C [GO:0071494]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; pyrimidine dimer repair [GO:0006290]; regulation of DNA repair [GO:0006282]; response to radiation [GO:0009314]; response to UV-C [GO:0010225]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:22801543, ECO:0000269|PubMed:24553286}. Note=Binding to ubiquitinated PCNA mediates colocalization to replication foci during DNA replication and persists at sites of stalled replication forks following UV irradiation (PubMed:12606586, PubMed:16357261, PubMed:24553286). After UV irradiation, recruited to DNA damage sites within 1 hour, to a maximum of about 80%; this recruitment may not be not restricted to cells active in DNA replication (PubMed:22801543). Colocalizes with TRAIP to nuclear foci (PubMed:24553286). {ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:22801543, ECO:0000269|PubMed:24553286}.
Q9Y255	reviewed	PRLD1_HUMAN	PRELI domain-containing protein 1, mitochondrial (25 kDa protein of relevant evolutionary and lymphoid interest) (Px19-like protein)	PRELID1 PRELI CGI-106 SBBI12	Homo sapiens (Human)	219	FUNCTION: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs. {ECO:0000269|PubMed:18945965, ECO:0000269|PubMed:21364629, ECO:0000269|PubMed:23931759}.		apoptotic process [GO:0006915]; intermembrane lipid transfer [GO:0120009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; phospholipid transport [GO:0015914]; positive regulation of cellular respiration [GO:1901857]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of T cell apoptotic process [GO:0070234]; regulation of membrane lipid distribution [GO:0097035]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of T cell differentiation [GO:0045580]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]		mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; apoptotic process [GO:0006915]; intermembrane lipid transfer [GO:0120009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; phospholipid transport [GO:0015914]; positive regulation of cellular respiration [GO:1901857]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of T cell apoptotic process [GO:0070234]; regulation of membrane lipid distribution [GO:0097035]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of T cell differentiation [GO:0045580]	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion intermembrane space {ECO:0000269|PubMed:14640972, ECO:0000269|PubMed:18945965, ECO:0000269|PubMed:21364629, ECO:0000269|PubMed:23931759}.
Q9Y256	reviewed	FACE2_HUMAN	CAAX prenyl protease 2 (EC 3.4.-.-) (Farnesylated proteins-converting enzyme 2) (FACE-2) (Prenyl protein-specific endoprotease 2) (RCE1 homolog) (hRCE1)	RCE1 FACE2 RCE1A RCE1B	Homo sapiens (Human)	329	FUNCTION: Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068). {ECO:0000269|PubMed:10085068, ECO:0000269|PubMed:11038283, ECO:0000269|PubMed:19188362}.		CAAX-box protein processing [GO:0071586]; MAPK cascade [GO:0000165]; protein prenylation [GO:0018342]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; exopeptidase activity [GO:0008238]; metalloendopeptidase activity [GO:0004222]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; exopeptidase activity [GO:0008238]; metalloendopeptidase activity [GO:0004222]; CAAX-box protein processing [GO:0071586]; MAPK cascade [GO:0000165]; protein prenylation [GO:0018342]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19188362}; Multi-pass membrane protein {ECO:0000269|PubMed:19188362}.
Q9Y257	reviewed	KCNK6_HUMAN	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence)	KCNK6 TOSS TWIK2	Homo sapiens (Human)	313	FUNCTION: Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.	MISCELLANEOUS: Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium.	negative regulation of systemic arterial blood pressure [GO:0003085]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of resting membrane potential [GO:0060075]; stabilization of membrane potential [GO:0030322]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	inward rectifier potassium channel activity [GO:0005242]; outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; inward rectifier potassium channel activity [GO:0005242]; outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]; negative regulation of systemic arterial blood pressure [GO:0003085]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of resting membrane potential [GO:0060075]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9Y258	reviewed	CCL26_HUMAN	C-C motif chemokine 26 (CC chemokine IMAC) (Eotaxin-3) (Macrophage inflammatory protein 4-alpha) (MIP-4-alpha) (Small-inducible cytokine A26) (Thymic stroma chemokine-1) (TSC-1)	CCL26 SCYA26 UNQ216/PRO242	Homo sapiens (Human)	94	FUNCTION: Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309). Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis (PubMed:20974991). {ECO:0000269|PubMed:10415065, ECO:0000269|PubMed:10488147, ECO:0000269|PubMed:11425309, ECO:0000269|PubMed:20974991}.		cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of chemotaxis [GO:0050921]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165]; T cell chemotaxis [GO:0010818]	extracellular space [GO:0005615]	CCR chemokine receptor binding [GO:0048020]; CCR3 chemokine receptor binding [GO:0031728]; chemokine activity [GO:0008009]; CX3C chemokine receptor binding [GO:0031737]; receptor ligand activity [GO:0048018]	extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; CCR3 chemokine receptor binding [GO:0031728]; chemokine activity [GO:0008009]; CX3C chemokine receptor binding [GO:0031737]; receptor ligand activity [GO:0048018]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of chemotaxis [GO:0050921]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165]; T cell chemotaxis [GO:0010818]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10488147}.
Q9Y259	reviewed	CHKB_HUMAN	Choline/ethanolamine kinase (Choline kinase beta) (CK) (CKB) (EC 2.7.1.32) (Choline kinase-like protein) (Ethanolamine kinase) (EK) (EC 2.7.1.82) (Ethanolamine kinase beta) (EKB) (choline/ethanolamine kinase beta) (CKEKB)	CHKB CHETK CHKL	Homo sapiens (Human)	395	FUNCTION: Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:19915674, ECO:0000269|PubMed:21665002}.	MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the CPT1B protein from a non-overlapping reading frame.	CDP-choline pathway [GO:0006657]; muscle organ development [GO:0007517]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; choline kinase activity [GO:0004103]; ethanolamine kinase activity [GO:0004305]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; choline kinase activity [GO:0004103]; ethanolamine kinase activity [GO:0004305]; CDP-choline pathway [GO:0006657]; muscle organ development [GO:0007517]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphorylation [GO:0016310]	
Q9Y261	reviewed	FOXA2_HUMAN	Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B)	FOXA2 HNF3B TCF3B	Homo sapiens (Human)	457	FUNCTION: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}.		adult locomotory behavior [GO:0008344]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cell fate specification [GO:0001708]; chromatin organization [GO:0006325]; DNA-templated transcription [GO:0006351]; dopaminergic neuron differentiation [GO:0071542]; endocrine pancreas development [GO:0031018]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of glucokinase activity [GO:0033132]; negative regulation of transcription from RNA polymerase II promoter by glucose [GO:0061987]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; primitive streak formation [GO:0090009]; regulation of blood coagulation [GO:0030193]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of transcription by RNA polymerase II [GO:0006357]; response to interleukin-6 [GO:0070741]	cell junction [GO:0030054]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nucleic acid binding [GO:0003676]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	cell junction [GO:0030054]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nucleic acid binding [GO:0003676]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; adult locomotory behavior [GO:0008344]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cell fate specification [GO:0001708]; chromatin organization [GO:0006325]; DNA-templated transcription [GO:0006351]; dopaminergic neuron differentiation [GO:0071542]; endocrine pancreas development [GO:0031018]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of glucokinase activity [GO:0033132]; negative regulation of transcription from RNA polymerase II promoter by glucose [GO:0061987]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; primitive streak formation [GO:0090009]; regulation of blood coagulation [GO:0030193]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of transcription by RNA polymerase II [GO:0006357]; response to interleukin-6 [GO:0070741]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:14500912}. Cytoplasm {ECO:0000269|PubMed:14500912}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
Q9Y262	reviewed	EIF3L_HUMAN	Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein)	EIF3L EIF3EIP EIF3S6IP HSPC021 HSPC025 MSTP005	Homo sapiens (Human)	564	FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03011, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.		formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synapse [GO:0045202]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synapse [GO:0045202]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
Q9Y263	reviewed	PLAP_HUMAN	Phospholipase A-2-activating protein (PLA2P) (PLAP)	PLAA PLAP	Homo sapiens (Human)	795	FUNCTION: Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). {ECO:0000250|UniProtKB:P27612, ECO:0000269|PubMed:18291623, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:28007986}.		cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; macroautophagy [GO:0016236]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; nervous system development [GO:0007399]; phospholipid metabolic process [GO:0006644]; positive regulation of dendrite extension [GO:1903861]; positive regulation of neuron migration [GO:2001224]; positive regulation of phospholipase A2 activity [GO:0032430]; positive regulation of synaptic vesicle recycling [GO:1903423]; prostaglandin metabolic process [GO:0006693]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; signal transduction [GO:0007165]; ubiquitin recycling [GO:0010992]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; synapse [GO:0045202]	phospholipase A2 activator activity [GO:0016005]; ubiquitin binding [GO:0043130]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; synapse [GO:0045202]; phospholipase A2 activator activity [GO:0016005]; ubiquitin binding [GO:0043130]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; macroautophagy [GO:0016236]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; nervous system development [GO:0007399]; phospholipid metabolic process [GO:0006644]; positive regulation of dendrite extension [GO:1903861]; positive regulation of neuron migration [GO:2001224]; positive regulation of phospholipase A2 activity [GO:0032430]; positive regulation of synaptic vesicle recycling [GO:1903423]; prostaglandin metabolic process [GO:0006693]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; signal transduction [GO:0007165]; ubiquitin recycling [GO:0010992]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28007986}. Cytoplasm {ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:28007986}. Synapse {ECO:0000250|UniProtKB:P27612}. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. {ECO:0000269|PubMed:27753622}.
Q9Y264	reviewed	ANGP4_HUMAN	Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3)	ANGPT4 ANG3 ANG4	Homo sapiens (Human)	503	FUNCTION: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. {ECO:0000269|PubMed:15284220}.		angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; Notch signaling pathway [GO:0007219]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; signal transduction [GO:0007165]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; Notch signaling pathway [GO:0007219]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9Y265	reviewed	RUVB1_HUMAN	RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)	RUVBL1 INO80H NMP238 TIP49 TIP49A	Homo sapiens (Human)	456	FUNCTION: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). Essential for cell proliferation (PubMed:14506706). May be able to bind plasminogen at cell surface and enhance plasminogen activation (PubMed:11027681). {ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11027681, ECO:0000269|PubMed:14506706, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:33205750}.	MISCELLANEOUS: High level of autoantibodies against RUVBL1 are detected in sera of patients with autoimmune diseases such as polymyositis/dermatomyosistis and autoimmune hepatitis.	box C/D snoRNP assembly [GO:0000492]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; telomere maintenance [GO:0000723]	cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular exosome [GO:0070062]; Ino80 complex [GO:0031011]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; DNA helicase activity [GO:0003678]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular exosome [GO:0070062]; Ino80 complex [GO:0031011]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; DNA helicase activity [GO:0003678]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription coactivator activity [GO:0003713]; box C/D snoRNP assembly [GO:0000492]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm {ECO:0000269|PubMed:11027681}. Membrane {ECO:0000269|PubMed:11027681}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Dynein axonemal particle {ECO:0000250|UniProtKB:Q9DE26}. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells.
Q9Y266	reviewed	NUDC_HUMAN	Nuclear migration protein nudC (Nuclear distribution protein C homolog)	NUDC	Homo sapiens (Human)	331	FUNCTION: Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12852857, PubMed:12679384, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12852857, PubMed:12679384). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}.		cell division [GO:0051301]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097]; protein folding [GO:0006457]; response to peptide hormone [GO:0043434]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; spindle [GO:0005819]	cadherin binding [GO:0045296]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; cadherin binding [GO:0045296]; unfolded protein binding [GO:0051082]; cell division [GO:0051301]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097]; protein folding [GO:0006457]; response to peptide hormone [GO:0043434]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Nucleus {ECO:0000269|PubMed:10210332}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25789526}. Midbody {ECO:0000269|PubMed:25789526}. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern. Localizes to the mitotic spindle in a EML4-dependent manner (PubMed:25789526). {ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:25789526}.
Q9Y267	reviewed	S22AE_HUMAN	Solute carrier family 22 member 14 (Organic cation transporter-like 4) (ORCTL-4)	SLC22A14 OCTL2 ORCTL4	Homo sapiens (Human)	594	FUNCTION: Riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa midpiece, which is required for male fertility (By similarity). SLC22A14-mediated riboflavin transport is essential for spermatozoa energy generation and motility: riboflavin is the precursor of FMN and FAD, which are coenzymes of many enzymes in the TCA cycle (the citric acid cycle) in mitochondria (By similarity). Required for sperm motility and normal sperm flagellar structure (By similarity). {ECO:0000250|UniProtKB:Q497L9}.		flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]	mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]	riboflavin transmembrane transporter activity [GO:0032217]	mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]; riboflavin transmembrane transporter activity [GO:0032217]; flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:33882315}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q497L9}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the principle piece of the sperm tail. {ECO:0000250|UniProtKB:Q497L9}.
Q9Y271	reviewed	CLTR1_HUMAN	Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81)	CYSLTR1 CYSLT1	Homo sapiens (Human)	337	FUNCTION: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.	MISCELLANEOUS: Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.	calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to oxygen-glucose deprivation [GO:0090650]; chemotaxis [GO:0006935]; defense response [GO:0006952]; establishment of localization in cell [GO:0051649]; inflammatory response to antigenic stimulus [GO:0002437]; neuropeptide signaling pathway [GO:0007218]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of vasoconstriction [GO:0045907]; respiratory gaseous exchange by respiratory system [GO:0007585]	membrane [GO:0016020]; plasma membrane [GO:0005886]	cysteinyl leukotriene receptor activity [GO:0001631]; G protein-coupled peptide receptor activity [GO:0008528]; leukotriene receptor activity [GO:0004974]	membrane [GO:0016020]; plasma membrane [GO:0005886]; cysteinyl leukotriene receptor activity [GO:0001631]; G protein-coupled peptide receptor activity [GO:0008528]; leukotriene receptor activity [GO:0004974]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to oxygen-glucose deprivation [GO:0090650]; chemotaxis [GO:0006935]; defense response [GO:0006952]; establishment of localization in cell [GO:0051649]; inflammatory response to antigenic stimulus [GO:0002437]; neuropeptide signaling pathway [GO:0007218]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of vasoconstriction [GO:0045907]; respiratory gaseous exchange by respiratory system [GO:0007585]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9Y272	reviewed	RASD1_HUMAN	Dexamethasone-induced Ras-related protein 1 (Activator of G-protein signaling 1)	RASD1 AGS1 DEXRAS1	Homo sapiens (Human)	281	FUNCTION: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity). {ECO:0000250}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of DNA-templated transcription [GO:0045892]; nitric oxide mediated signal transduction [GO:0007263]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]	G-protein beta-subunit binding [GO:0031681]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; G-protein beta-subunit binding [GO:0031681]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of DNA-templated transcription [GO:0045892]; nitric oxide mediated signal transduction [GO:0007263]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}.
Q9Y274	reviewed	SIA10_HUMAN	Type 2 lactosamine alpha-2,3-sialyltransferase (EC 2.4.99.-) (CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI) (ST3Gal VI) (ST3GalVI) (Sialyltransferase 10)	ST3GAL6 SIAT10	Homo sapiens (Human)	331	FUNCTION: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.		cellular response to interleukin-6 [GO:0071354]; glycolipid biosynthetic process [GO:0009247]; keratan sulfate biosynthetic process [GO:0018146]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; beta-galactoside alpha-2,3-sialyltransferase activity [GO:0052798]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; beta-galactoside alpha-2,3-sialyltransferase activity [GO:0052798]; cellular response to interleukin-6 [GO:0071354]; glycolipid biosynthetic process [GO:0009247]; keratan sulfate biosynthetic process [GO:0018146]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9Y275	reviewed	TN13B_HUMAN	Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]	TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 UNQ401/PRO738	Homo sapiens (Human)	285	FUNCTION: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:10973284}.; FUNCTION: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. {ECO:0000250}.; FUNCTION: [Isoform 3]: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. {ECO:0000269|PubMed:10973284}.		B cell costimulation [GO:0031296]; B cell differentiation [GO:0030183]; B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; germinal center formation [GO:0002467]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of germinal center formation [GO:0002636]; positive regulation of T cell proliferation [GO:0042102]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; B cell costimulation [GO:0031296]; B cell differentiation [GO:0030183]; B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; germinal center formation [GO:0002467]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of germinal center formation [GO:0002636]; positive regulation of T cell proliferation [GO:0042102]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 13b, soluble form]: Secreted.
Q9Y276	reviewed	BCS1_HUMAN	Mitochondrial chaperone BCS1 (h-BCS1) (BCS1-like protein)	BCS1L BCS1	Homo sapiens (Human)	419	FUNCTION: Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. {ECO:0000269|PubMed:18628306}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrial respiratory chain complex III assembly [GO:0034551]; mitochondrion organization [GO:0007005]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrial respiratory chain complex III assembly [GO:0034551]; mitochondrion organization [GO:0007005]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:9878253}; Single-pass membrane protein {ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:9878253}.
Q9Y277	reviewed	VDAC3_HUMAN	Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3)	VDAC3	Homo sapiens (Human)	283	FUNCTION: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). Involved in male fertility and sperm mitochondrial sheath formation (By similarity). {ECO:0000250|UniProtKB:P21796, ECO:0000250|UniProtKB:Q60931}.		adenine transport [GO:0015853]; sperm mitochondrial sheath assembly [GO:0120317]; spermatogenesis [GO:0007283]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pore complex [GO:0046930]	nucleotide binding [GO:0000166]; porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pore complex [GO:0046930]; nucleotide binding [GO:0000166]; porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308]; adenine transport [GO:0015853]; sperm mitochondrial sheath assembly [GO:0120317]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21796}. Membrane {ECO:0000269|PubMed:27641616}. Note=May localize to non-mitochondrial membranes. {ECO:0000269|PubMed:27641616}.
Q9Y278	reviewed	HS3S2_HUMAN	Heparan sulfate glucosamine 3-O-sulfotransferase 2 (EC 2.8.2.29) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2) (3-OST-2) (Heparan sulfate 3-O-sulfotransferase 2) (h3-OST-2)	HS3ST2 3OST2 UNQ2442/PRO5004	Homo sapiens (Human)	367	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:9988768). Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS (PubMed:9988768). Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:9988768). {ECO:0000269|PubMed:9988768}.		glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity [GO:0033871]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity [GO:0033871]; sulfotransferase activity [GO:0008146]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9Y279	reviewed	VSIG4_HUMAN	V-set and immunoglobulin domain-containing protein 4 (Protein Z39Ig)	VSIG4 CRIg Z39IG UNQ317/PRO362	Homo sapiens (Human)	399	FUNCTION: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. {ECO:0000269|PubMed:17016562, ECO:0000269|PubMed:17051150}.		complement activation, alternative pathway [GO:0006957]; negative regulation of complement activation, alternative pathway [GO:0045957]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of macrophage activation [GO:0043031]; negative regulation of T cell proliferation [GO:0042130]	membrane [GO:0016020]; protein-containing complex [GO:0032991]	complement component C3b binding [GO:0001851]	membrane [GO:0016020]; protein-containing complex [GO:0032991]; complement component C3b binding [GO:0001851]; complement activation, alternative pathway [GO:0006957]; negative regulation of complement activation, alternative pathway [GO:0045957]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of macrophage activation [GO:0043031]; negative regulation of T cell proliferation [GO:0042130]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9Y281	reviewed	COF2_HUMAN	Cofilin-2 (Cofilin, muscle isoform)	CFL2	Homo sapiens (Human)	166	FUNCTION: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). {ECO:0000250|UniProtKB:P45591, ECO:0000269|PubMed:19752190}.		actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; actin filament severing [GO:0051014]; muscle cell cellular homeostasis [GO:0046716]; positive regulation of actin filament depolymerization [GO:0030836]; sarcomere organization [GO:0045214]; skeletal muscle tissue development [GO:0007519]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; I band [GO:0031674]; nuclear matrix [GO:0016363]; Z disc [GO:0030018]	actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; I band [GO:0031674]; nuclear matrix [GO:0016363]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; actin filament severing [GO:0051014]; muscle cell cellular homeostasis [GO:0046716]; positive regulation of actin filament depolymerization [GO:0030836]; sarcomere organization [GO:0045214]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with CSPR3 in the Z line of sarcomeres. {ECO:0000269|PubMed:19752190}.
Q9Y282	reviewed	ERGI3_HUMAN	Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84)	ERGIC3 C20orf47 ERV46 SDBCAG84 CGI-54 PRO0989	Homo sapiens (Human)	383	FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins SERPINA1/alpha1-antitrypsin and HP/haptoglobin (PubMed:31142615). {ECO:0000269|PubMed:31142615}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of intracellular protein transport [GO:0090316]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; retrograde transporter complex, Golgi to ER [GO:0061852]; transporter complex [GO:1990351]	protein self-association [GO:0043621]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; retrograde transporter complex, Golgi to ER [GO:0061852]; transporter complex [GO:1990351]; protein self-association [GO:0043621]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of intracellular protein transport [GO:0090316]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:15308636}; Multi-pass membrane protein {ECO:0000269|PubMed:15308636}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:15308636}; Multi-pass membrane protein {ECO:0000269|PubMed:15308636}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15308636}; Multi-pass membrane protein {ECO:0000269|PubMed:15308636}. Note=Cycles between the endoplasmic reticulum and the Golgi.
Q9Y283	reviewed	INVS_HUMAN	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2)	INVS INV NPHP2	Homo sapiens (Human)	1065	FUNCTION: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15852005, ECO:0000269|PubMed:18371931}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein localization to ciliary inversin compartment [GO:1904108]; Wnt signaling pathway [GO:0016055]	ciliary inversin compartment [GO:0097543]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle [GO:0005819]	calmodulin binding [GO:0005516]	ciliary inversin compartment [GO:0097543]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle [GO:0005819]; calmodulin binding [GO:0005516]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein localization to ciliary inversin compartment [GO:1904108]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, cilium {ECO:0000269|PubMed:12872123}. Note=Associates with several components of the cytoskeleton including ciliary, random and polarized microtubules. During mitosis, it is recruited to mitotic spindle. Frequently membrane-associated, membrane localization is dependent upon cell-cell contacts and is redistributed when cell adhesion is disrupted after incubation of the cell monolayer with low-calcium/EGTA medium.
Q9Y284	reviewed	ASTER_HUMAN	PAT complex subunit Asterix (Protein associated with the ER translocon of 10kDa) (PAT-10) (PAT10) (WD repeat domain 83 opposite strand) (WDR83 opposite strand)	WDR83OS C19orf56 CGI-140 My006 PTD008	Homo sapiens (Human)	106	FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:12475939, PubMed:32814900, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:32814900, PubMed:36261522). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity). Within the PAT subcomplex, WDR83OS/Asterix binds to and redirects the substrate to a location behind the SEC61 complex (By similarity). {ECO:0000250|UniProtKB:A0A8I3NQW8, ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:32814900, ECO:0000269|PubMed:36261522}.		multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; protein insertion into ER membrane [GO:0045048]	endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]; protein folding chaperone complex [GO:0101031]	protein folding chaperone [GO:0044183]	endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]; protein folding chaperone complex [GO:0101031]; protein folding chaperone [GO:0044183]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; protein insertion into ER membrane [GO:0045048]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:32814900, ECO:0000269|PubMed:36261522}; Multi-pass membrane protein {ECO:0000305|PubMed:12475939}.
Q9Y285	reviewed	SYFA_HUMAN	Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)	FARSA FARS FARSL FARSLA	Homo sapiens (Human)	508			phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phenylalanine-tRNA ligase complex [GO:0009328]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phenylalanine-tRNA ligase complex [GO:0009328]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]; phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q505J8}.
Q9Y286	reviewed	SIGL7_HUMAN	Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328)	SIGLEC7 AIRM1	Homo sapiens (Human)	467	FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell adhesion [GO:0007155]	plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; signaling receptor activity [GO:0038023]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9Y287	reviewed	ITM2B_HUMAN	Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]	ITM2B BRI BRI2	Homo sapiens (Human)	266	FUNCTION: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.; FUNCTION: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.; FUNCTION: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.		negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; nervous system development [GO:0007399]	endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]	amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]	endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: [Integral membrane protein 2B]: Golgi apparatus membrane {ECO:0000269|PubMed:14656991, ECO:0000269|PubMed:19114711}; Single-pass type II membrane protein {ECO:0000269|PubMed:10526337}. Note=Immature BRI2 (imBRI2) is cleaved by furin in the Golgi into mBRI2 and a Bri23 peptide. mBRI2 is transported to the plasma membrane and Bri23 peptide is secreted.; SUBCELLULAR LOCATION: [BRI2, membrane form]: Cell membrane {ECO:0000269|PubMed:18440095, ECO:0000269|PubMed:19748705, ECO:0000269|PubMed:21752865}; Single-pass type II membrane protein {ECO:0000269|PubMed:10526337}. Endosome membrane {ECO:0000269|PubMed:19748705}; Single-pass type II membrane protein {ECO:0000269|PubMed:10526337}. Note=Mature BRI2 (mBRI2) needs to be transported from the endoplasmic reticulum compartment to the cell membrane in order to be able to inhibit APP processing. {ECO:0000269|PubMed:19748705}.; SUBCELLULAR LOCATION: [Bri23 peptide]: Secreted {ECO:0000269|PubMed:10526337, ECO:0000269|PubMed:14656991, ECO:0000269|PubMed:18524908}. Note=Detected in the cerebral spinal fluid (CSF). {ECO:0000269|PubMed:18524908}.; SUBCELLULAR LOCATION: [BRI2C, soluble form]: Secreted {ECO:0000269|PubMed:17965014}.
Q9Y289	reviewed	SC5A6_HUMAN	Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6)	SLC5A6 SMVT	Homo sapiens (Human)	635	FUNCTION: Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:10329687, PubMed:15561972, PubMed:19211916, PubMed:21570947, PubMed:20980265, PubMed:22015582, PubMed:25971966, PubMed:25809983, PubMed:28052864, PubMed:27904971, PubMed:31754459). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (PubMed:10329687, PubMed:20980265). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:19211916). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983). {ECO:0000250|UniProtKB:Q5U4D8, ECO:0000269|PubMed:10329687, ECO:0000269|PubMed:15561972, ECO:0000269|PubMed:19211916, ECO:0000269|PubMed:20980265, ECO:0000269|PubMed:21570947, ECO:0000269|PubMed:22015582, ECO:0000269|PubMed:25809983, ECO:0000269|PubMed:25971966, ECO:0000269|PubMed:27904971, ECO:0000269|PubMed:28052864, ECO:0000269|PubMed:31754459}.		biotin import across plasma membrane [GO:1905135]; biotin metabolic process [GO:0006768]; biotin transport [GO:0015878]; iodide transmembrane transport [GO:1904200]; pantothenate transmembrane transport [GO:0015887]; sodium ion transport [GO:0006814]; transport across blood-brain barrier [GO:0150104]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]	biotin transmembrane transporter activity [GO:0015225]; iodide transmembrane transporter activity [GO:0015111]; monocarboxylate:sodium symporter activity [GO:0140161]; pantothenate transmembrane transporter activity [GO:0015233]; pantothenate:sodium symporter activity [GO:0015498]; sodium-dependent multivitamin transmembrane transporter activity [GO:0008523]; vitamin transmembrane transporter activity [GO:0090482]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]; biotin transmembrane transporter activity [GO:0015225]; iodide transmembrane transporter activity [GO:0015111]; monocarboxylate:sodium symporter activity [GO:0140161]; pantothenate transmembrane transporter activity [GO:0015233]; pantothenate:sodium symporter activity [GO:0015498]; sodium-dependent multivitamin transmembrane transporter activity [GO:0008523]; vitamin transmembrane transporter activity [GO:0090482]; biotin import across plasma membrane [GO:1905135]; biotin metabolic process [GO:0006768]; biotin transport [GO:0015878]; iodide transmembrane transport [GO:1904200]; pantothenate transmembrane transport [GO:0015887]; sodium ion transport [GO:0006814]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25809983, ECO:0000269|PubMed:27904971, ECO:0000269|PubMed:35013551}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19211916}; Multi-pass membrane protein {ECO:0000255}. Note=Preferentially localized at the luminal membrane of brain capillary endothelium (PubMed:25809983). Localized to the brush border/apical membrane of intestine and renal polarized cells (PubMed:19211916). {ECO:0000269|PubMed:19211916, ECO:0000269|PubMed:25809983}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28052864}; Multi-pass membrane protein {ECO:0000255}. Note=(Microbial infection) Exposure to E.coli lipopolysaccharides leads to reduced cell membrane localization. {ECO:0000269|PubMed:28052864}.
Q9Y294	reviewed	ASF1A_HUMAN	Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA)	ASF1A CGI-98 HSPC146	Homo sapiens (Human)	204	FUNCTION: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485, ECO:0000269|PubMed:29478807}.		DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; DNA replication-dependent chromatin assembly [GO:0006335]; muscle cell differentiation [GO:0042692]; nucleosome assembly [GO:0006334]; osteoblast differentiation [GO:0001649]; replication fork processing [GO:0031297]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; DNA replication-dependent chromatin assembly [GO:0006335]; muscle cell differentiation [GO:0042692]; nucleosome assembly [GO:0006334]; osteoblast differentiation [GO:0001649]; replication fork processing [GO:0031297]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904}. Chromosome {ECO:0000269|PubMed:29478807}.
Q9Y295	reviewed	DRG1_HUMAN	Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-)	DRG1 NEDD3	Homo sapiens (Human)	367	FUNCTION: Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155, ECO:0000269|PubMed:28855639, ECO:0000269|PubMed:29915238}.		cytoplasmic translation [GO:0002181]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic spindle assembly [GO:1901673]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; potassium ion binding [GO:0030955]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; potassium ion binding [GO:0030955]; cytoplasmic translation [GO:0002181]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic spindle assembly [GO:1901673]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29915238}. Cytoplasm {ECO:0000269|PubMed:15676025, ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:29915238}. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes.
Q9Y296	reviewed	TPPC4_HUMAN	Trafficking protein particle complex subunit 4 (Hematopoietic stem/progenitor cell protein 172) (Synbindin) (TRS23 homolog)	TRAPPC4 SBDN CGI-104 HSPC172 PTD009	Homo sapiens (Human)	219	FUNCTION: Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable). Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024). May play a role in dendrite postsynaptic membrane trafficking (By similarity). {ECO:0000250|UniProtKB:Q9ES56, ECO:0000269|PubMed:31794024, ECO:0000305|PubMed:31794024}.		autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; dendrite development [GO:0016358]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]; autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; dendrite development [GO:0016358]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9ES56}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ES56}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9ES56}. Vesicle {ECO:0000250|UniProtKB:Q9ES56}. Note=Associated with postsynaptic membranes and in intracellular cisterns and vesicles (Golgi). {ECO:0000250|UniProtKB:Q9ES56}.
Q9Y297	reviewed	FBW1A_HUMAN	F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)	BTRC BTRCP FBW1A FBXW1A	Homo sapiens (Human)	605	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10066435, PubMed:10497169, PubMed:9990852, PubMed:10644755, PubMed:10835356, PubMed:11238952, PubMed:11359933, PubMed:11158290, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:25503564, PubMed:25704143, PubMed:9859996, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:36608670). Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:9990852, PubMed:10644755, PubMed:10835356, PubMed:11238952, PubMed:11359933, PubMed:11158290, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:25503564, PubMed:25704143, PubMed:9859996, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:36608670). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14681206, PubMed:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:9859996, PubMed:10066435, PubMed:10497169, PubMed:10644755). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (PubMed:10835356, PubMed:11158290, PubMed:14673179). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PubMed:21258371, PubMed:18354482). SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (By similarity). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:33110214, PubMed:36608670). {ECO:0000250|UniProtKB:Q3ULA2, ECO:0000269|PubMed:10066435, ECO:0000269|PubMed:10497169, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10835356, ECO:0000269|PubMed:11158290, ECO:0000269|PubMed:11238952, ECO:0000269|PubMed:11359933, ECO:0000269|PubMed:11994270, ECO:0000269|PubMed:12077367, ECO:0000269|PubMed:12791267, ECO:0000269|PubMed:12820959, ECO:0000269|PubMed:12902344, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988407, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16371461, ECO:0000269|PubMed:18354482, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:22087322, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:9859996, ECO:0000269|PubMed:9990852}.		branching involved in mammary gland duct morphogenesis [GO:0060444]; cellular response to organic cyclic compound [GO:0071407]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of smoothened signaling pathway [GO:0045879]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteolysis [GO:0045862]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of proteasomal protein catabolic process [GO:0061136]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]	beta-catenin binding [GO:0008013]; ligase activity [GO:0016874]; protein dimerization activity [GO:0046983]; protein phosphorylated amino acid binding [GO:0045309]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]; beta-catenin binding [GO:0008013]; ligase activity [GO:0016874]; protein dimerization activity [GO:0046983]; protein phosphorylated amino acid binding [GO:0045309]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase activity [GO:0061630]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cellular response to organic cyclic compound [GO:0071407]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of smoothened signaling pathway [GO:0045879]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteolysis [GO:0045862]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of proteasomal protein catabolic process [GO:0061136]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3ULA2}. Nucleus {ECO:0000250|UniProtKB:Q3ULA2}.
Q9Y2A7	reviewed	NCKP1_HUMAN	Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1)	NCKAP1 HEM2 KIAA0587 NAP1	Homo sapiens (Human)	1128	FUNCTION: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:P28660}.		apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; cortical actin cytoskeleton organization [GO:0030866]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; Rac protein signal transduction [GO:0016601]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; ruffle [GO:0001726]; SCAR complex [GO:0031209]		cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; ruffle [GO:0001726]; SCAR complex [GO:0031209]; apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; cortical actin cytoskeleton organization [GO:0030866]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; Rac protein signal transduction [GO:0016601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P28660}; Single-pass membrane protein {ECO:0000250|UniProtKB:P28660}; Cytoplasmic side {ECO:0000250|UniProtKB:P28660}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:P28660}; Single-pass membrane protein {ECO:0000250|UniProtKB:P28660}; Cytoplasmic side {ECO:0000250|UniProtKB:P28660}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250|UniProtKB:P28660}.
Q9Y2A9	reviewed	B3GN3_HUMAN	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 (EC 2.4.1.149) (Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) (EC 2.4.1.146) (Beta-1,3-galactosyltransferase 8) (Beta-1,3-GalTase 8) (Beta3Gal-T8) (Beta3GalT8) (b3Gal-T8) (Beta-3-Gx-T8) (Core 1 extending beta-1,3-N-acetylglucosaminyltransferase) (Core1-beta3GlcNAcT) (Transmembrane protein 3) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3) (BGnT-3) (Beta-1,3-Gn-T3) (Beta-1,3-N-acetylglucosaminyltransferase 3) (Beta3Gn-T3) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8)	B3GNT3 B3GALT8 TMEM3 UNQ637/PRO1266	Homo sapiens (Human)	372	FUNCTION: Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191). {ECO:0000269|PubMed:11042166, ECO:0000269|PubMed:11439191}.		keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity [GO:0008457]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity [GO:0008457]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9Y2B0	reviewed	CNPY2_HUMAN	Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4)	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	Homo sapiens (Human)	182	FUNCTION: Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.		negative regulation of gene expression [GO:0010629]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; regulation of low-density lipoprotein particle clearance [GO:0010988]	endoplasmic reticulum [GO:0005783]		endoplasmic reticulum [GO:0005783]; negative regulation of gene expression [GO:0010629]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; regulation of low-density lipoprotein particle clearance [GO:0010988]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q9Y2B1	reviewed	RXLT1_HUMAN	Ribitol-5-phosphate xylosyltransferase 1 (EC 2.4.2.61) (Transmembrane protein 5) (UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase)	RXYLT1 TMEM5	Homo sapiens (Human)	443	FUNCTION: Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan (PubMed:27733679, PubMed:29477842) (Probable). Participates in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:27601598, PubMed:27733679) (Probable). {ECO:0000269|PubMed:25279699, ECO:0000269|PubMed:27601598, ECO:0000269|PubMed:27733679, ECO:0000269|PubMed:29477842, ECO:0000305|PubMed:27130732}.		protein O-linked mannosylation [GO:0035269]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	ribitol beta-1,4-xylosyltransferase activity [GO:0120053]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ribitol beta-1,4-xylosyltransferase activity [GO:0120053]; protein O-linked mannosylation [GO:0035269]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:25279699, ECO:0000269|PubMed:29477842}; Single-pass type II membrane protein {ECO:0000305}.
Q9Y2B4	reviewed	T53G5_HUMAN	TP53-target gene 5 protein (TP53-inducible gene 5 protein)	TP53TG5 C20orf10	Homo sapiens (Human)	290	FUNCTION: May play a significant role in p53/TP53-mediating signaling pathway. {ECO:0000269|PubMed:10719363}.		intracellular signal transduction [GO:0035556]; negative regulation of cell growth [GO:0030308]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]		chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; intracellular signal transduction [GO:0035556]; negative regulation of cell growth [GO:0030308]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10719363}. Nucleus {ECO:0000269|PubMed:10719363}. Note=Cell cycle dependent intracellular localization.
Q9Y2B5	reviewed	VP9D1_HUMAN	VPS9 domain-containing protein 1 (Protein ATP-BL)	VPS9D1 ATPBL C16orf7	Homo sapiens (Human)	631			proton motive force-driven ATP synthesis [GO:0015986]; vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; endocytic vesicle [GO:0030139]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; proton motive force-driven ATP synthesis [GO:0015986]; vesicle-mediated transport [GO:0016192]	
Q9Y2C3	reviewed	B3GT5_HUMAN	Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)	B3GALT5	Homo sapiens (Human)	310	FUNCTION: Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor. {ECO:0000269|PubMed:10406968, ECO:0000269|PubMed:10837462}.		lipid metabolic process [GO:0006629]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]; response to bacterium [GO:0009617]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; lipid metabolic process [GO:0006629]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9Y2C4	reviewed	EXOG_HUMAN	Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1)	EXOG ENDOGL1 ENDOGL2 ENGL	Homo sapiens (Human)	368	FUNCTION: Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity. {ECO:0000269|PubMed:18187503}.	MISCELLANEOUS: The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules. {ECO:0000250}.; MISCELLANEOUS: [Isoform 2]: Probably inactive since it lacks the active site. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Probably inactive since it lacks the active site. {ECO:0000305}.	apoptotic DNA fragmentation [GO:0006309]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	5'-3' exonuclease activity [GO:0008409]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; RNA endonuclease activity [GO:0004521]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; 5'-3' exonuclease activity [GO:0008409]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; RNA endonuclease activity [GO:0004521]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; apoptotic DNA fragmentation [GO:0006309]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:18187503}.
Q9Y2C5	reviewed	S17A4_HUMAN	Probable small intestine urate exporter (Solute carrier family 17 member 4)	SLC17A4	Homo sapiens (Human)	497	FUNCTION: Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions (PubMed:22460716). Mediates chloride-dependent transport of urate (PubMed:22460716). Mediates sodium-independent high affinity transport of thyroid hormones including L-thyroxine (T4) and 3,3',5-triiodo-L-thyronine (T3) (PubMed:30367059, PubMed:34937426). Can actively transport inorganic phosphate into cells via Na(+) cotransport (PubMed:22460716). {ECO:0000269|PubMed:22460716, ECO:0000269|PubMed:30367059, ECO:0000269|PubMed:34937426}.		monoatomic anion transport [GO:0006820]; phosphate-containing compound metabolic process [GO:0006796]; sodium ion transport [GO:0006814]; sodium-dependent phosphate transport [GO:0044341]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]	sodium:phosphate symporter activity [GO:0005436]; thyroid hormone transmembrane transporter activity [GO:0015349]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sodium:phosphate symporter activity [GO:0005436]; thyroid hormone transmembrane transporter activity [GO:0015349]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143]; monoatomic anion transport [GO:0006820]; phosphate-containing compound metabolic process [GO:0006796]; sodium ion transport [GO:0006814]; sodium-dependent phosphate transport [GO:0044341]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:22460716}; Multi-pass membrane protein {ECO:0000255}. Note=Apical in the intestinal brush border. {ECO:0000269|PubMed:22460716}.
Q9Y2C9	reviewed	TLR6_HUMAN	Toll-like receptor 6 (CD antigen CD286)	TLR6	Homo sapiens (Human)	796	FUNCTION: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584). {ECO:0000269|PubMed:11441107, ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:20037584}.		activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; nitric oxide metabolic process [GO:0046209]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macrophage activation [GO:0043032]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]; amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD(P)+ nucleosidase activity [GO:0050135]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; nitric oxide metabolic process [GO:0046209]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macrophage activation [GO:0043032]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20037584}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9EPW9}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus {ECO:0000269|PubMed:16880211}. Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus (PubMed:16880211). {ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:20037584}.
Q9Y2D0	reviewed	CAH5B_HUMAN	Carbonic anhydrase 5B, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VB) (Carbonic anhydrase VB) (CA-VB)	CA5B	Homo sapiens (Human)	317	FUNCTION: Reversible hydration of carbon dioxide.		one-carbon metabolic process [GO:0006730]; response to bacterium [GO:0009617]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]; one-carbon metabolic process [GO:0006730]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Mitochondrion.
Q9Y2D1	reviewed	ATF5_HUMAN	Cyclic AMP-dependent transcription factor ATF-5 (cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5) (Transcription factor ATFx)	ATF5 ATFX	Homo sapiens (Human)	282	FUNCTION: Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385). {ECO:0000250|UniProtKB:O70191, ECO:0000250|UniProtKB:Q6P788, ECO:0000269|PubMed:10373550, ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:18332083, ECO:0000269|PubMed:18701499, ECO:0000269|PubMed:20654631, ECO:0000269|PubMed:21212266, ECO:0000269|PubMed:21791614, ECO:0000269|PubMed:22442021, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:24216764, ECO:0000269|PubMed:24379400, ECO:0000269|PubMed:25512613, ECO:0000269|PubMed:26213385}.		cerebellar granule cell precursor proliferation [GO:0021930]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle G2/M phase transition [GO:1902750]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; olfactory bulb interneuron development [GO:0021891]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of centrosome cycle [GO:0046605]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; kinase binding [GO:0019900]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; tubulin binding [GO:0015631]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; kinase binding [GO:0019900]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; tubulin binding [GO:0015631]; cerebellar granule cell precursor proliferation [GO:0021930]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle G2/M phase transition [GO:1902750]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; olfactory bulb interneuron development [GO:0021891]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of centrosome cycle [GO:0046605]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15358120}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:22528486}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26213385}. Note=Actively transported to the centrosome and accumulated in the pericentriolar material (PCM) during G1 to M phase via a microtubule-dependent mechanism. During late telophase and cytokinesis, translocates from the centrosome to the midbody. {ECO:0000269|PubMed:26213385}.
Q9Y2D2	reviewed	S35A3_HUMAN	UDP-N-acetylglucosamine transporter (Golgi UDP-GlcNAc transporter) (Solute carrier family 35 member A3)	SLC35A3	Homo sapiens (Human)	325	FUNCTION: Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP (PubMed:10393322). May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate (PubMed:23766508, PubMed:34981577). However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter (PubMed:32938718). {ECO:0000269|PubMed:10393322, ECO:0000269|PubMed:23766508, ECO:0000269|PubMed:32938718, ECO:0000269|PubMed:34981577}.		carbohydrate transport [GO:0008643]; UDP-N-acetylglucosamine metabolic process [GO:0006047]; UDP-N-acetylglucosamine transmembrane transport [GO:1990569]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	antiporter activity [GO:0015297]; UDP-galactose transmembrane transporter activity [GO:0005459]; UDP-N-acetylglucosamine transmembrane transporter activity [GO:0005462]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; antiporter activity [GO:0015297]; UDP-galactose transmembrane transporter activity [GO:0005459]; UDP-N-acetylglucosamine transmembrane transporter activity [GO:0005462]; carbohydrate transport [GO:0008643]; UDP-N-acetylglucosamine metabolic process [GO:0006047]; UDP-N-acetylglucosamine transmembrane transport [GO:1990569]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:10393322, ECO:0000269|PubMed:23766508, ECO:0000269|PubMed:28167211}; Multi-pass membrane protein {ECO:0000255}.
Q9Y2D4	reviewed	EXC6B_HUMAN	Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2)	EXOC6B KIAA0919 SEC15B SEC15L2	Homo sapiens (Human)	811	FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.		exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	exocyst [GO:0000145]		exocyst [GO:0000145]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	
Q9Y2D5	reviewed	PLAK2_HUMAN	PALM2-AKAP2 fusion protein (A-kinase anchor protein 2) (AKAP-2) (AKAP-KL) (Paralemmin A kinase anchor protein) (Paralemmin-2) (Protein kinase A-anchoring protein 2) (PRKA2)	PALM2AKAP2 KIAA0920 PAKAP PALM2	Homo sapiens (Human)	1103	FUNCTION: Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Binds to and modulates the structure of the actin cytoskeleton. {ECO:0000250|UniProtKB:O54931}.	MISCELLANEOUS: [Isoform 3]: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein. {ECO:0000305}.	regulation of cell shape [GO:0008360]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:O54931}; Lipid-anchor, GPI-like-anchor {ECO:0000250|UniProtKB:O54931}; Cytoplasmic side {ECO:0000250|UniProtKB:O54931}. Note=Accumulates near the inner, apical surface of highly polarized epithelium in tubules of nephrons. {ECO:0000250|UniProtKB:O54931}.
Q9Y2D8	reviewed	ADIP_HUMAN	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein)	SSX2IP KIAA0923	Homo sapiens (Human)	614	FUNCTION: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}.	MISCELLANEOUS: Acts as an acute myeloid leukemia-associated antigen and may be used as a potential immunotherapy target for leukemia (PubMed:17686061, PubMed:19179477). {ECO:0000305|PubMed:17686061, ECO:0000305|PubMed:19179477}.	cell adhesion [GO:0007155]; centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of cell motility [GO:2000145]; regulation of Rac protein signal transduction [GO:0035020]	adherens junction [GO:0005912]; cell leading edge [GO:0031252]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]		adherens junction [GO:0005912]; cell leading edge [GO:0031252]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; cell adhesion [GO:0007155]; centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of cell motility [GO:2000145]; regulation of Rac protein signal transduction [GO:0035020]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24356449}. Note=Not found at cell-matrix AJs. {ECO:0000250}.
Q9Y2E5	reviewed	MA2B2_HUMAN	Epididymis-specific alpha-mannosidase (EC 3.2.1.24) (Alpha-1,6-mannosidase) (Mannosidase alpha class 2B member 2)	MAN2B2 KIAA0935	Homo sapiens (Human)	1009			mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9Y2E6	reviewed	DTX4_HUMAN	E3 ubiquitin-protein ligase DTX4 (EC 2.3.2.27) (Protein deltex-4) (Deltex4) (RING finger protein 155) (RING-type E3 ubiquitin transferase DTX4)	DTX4 KIAA0937 RNF155	Homo sapiens (Human)	619	FUNCTION: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. {ECO:0000250, ECO:0000269|PubMed:22388039}.		negative regulation of innate immune response [GO:0045824]; Notch signaling pathway [GO:0007219]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of type I interferon production [GO:0032479]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; negative regulation of innate immune response [GO:0045824]; Notch signaling pathway [GO:0007219]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of type I interferon production [GO:0032479]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9Y2E8	reviewed	SL9A8_HUMAN	Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8)	SLC9A8 KIAA0939 NHE8	Homo sapiens (Human)	581	FUNCTION: Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (PubMed:15522866). Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (PubMed:15522866, PubMed:20719963). In germ cells, plays a crucial role in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap (By similarity). Can also be active at the cell surface of specialized cells. In the small intestine, at the cell membrane, plays a major physiological role in transepithelial absorption of Na(+) and regulates intracellular pH homeostasis of intestinal epithelial cells (PubMed:34288721). Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins (By similarity). Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (By similarity). {ECO:0000250|UniProtKB:Q8R4D1, ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:20719963, ECO:0000269|PubMed:34288721}.		acrosome assembly [GO:0001675]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; proton transmembrane transport [GO:1902600]; regulation of Golgi lumen acidification [GO:1905526]; regulation of intracellular pH [GO:0051453]; sodium ion transmembrane transport [GO:0035725]	acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; Golgi membrane [GO:0000139]; multivesicular body membrane [GO:0032585]; trans-Golgi network membrane [GO:0032588]	potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; Golgi membrane [GO:0000139]; multivesicular body membrane [GO:0032585]; trans-Golgi network membrane [GO:0032588]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; acrosome assembly [GO:0001675]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; proton transmembrane transport [GO:1902600]; regulation of Golgi lumen acidification [GO:1905526]; regulation of intracellular pH [GO:0051453]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15522866}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:20719963}; Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:20719963}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:34288721}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8R4D1}. Note=Intracellular versus plasma membrane-resident location may vary with cell type. Mainly localized to the mid- to trans-Golgi compartments but a proportion is also localized to multivesicular bodies (PubMed:15522866, PubMed:20719963). Localized at the apical membrane of polarized gastrointestinal epithelial cells (By similarity). Recruitment to the plasma membrane upon acid stimulation (By similarity). {ECO:0000250|UniProtKB:Q4L208, ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:20719963}.
Q9Y2F5	reviewed	ICE1_HUMAN	Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1)	ICE1 KIAA0947	Homo sapiens (Human)	2266	FUNCTION: Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}.		positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of transcription by RNA polymerase III [GO:0045945]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]	Cajal body [GO:0015030]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]	protein-macromolecule adaptor activity [GO:0030674]	Cajal body [GO:0015030]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]; protein-macromolecule adaptor activity [GO:0030674]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of transcription by RNA polymerase III [GO:0045945]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. Nucleus, Cajal body {ECO:0000269|PubMed:23932780}. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Associates to transcriptionally active chromatin at snRNA genes. {ECO:0000269|PubMed:23932780}.
Q9Y2F9	reviewed	BTBD3_HUMAN	BTB/POZ domain-containing protein 3	BTBD3 KIAA0952	Homo sapiens (Human)	522	FUNCTION: Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity). {ECO:0000250}.		cerebral cortex development [GO:0021987]; dendrite morphogenesis [GO:0048813]; neurogenesis [GO:0022008]	cytosol [GO:0005829]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; cerebral cortex development [GO:0021987]; dendrite morphogenesis [GO:0048813]; neurogenesis [GO:0022008]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates from the cytosol to the nucleus in response to neuronal activity. {ECO:0000250}.
Q9Y2G0	reviewed	EFR3B_HUMAN	Protein EFR3 homolog B	EFR3B KIAA0953	Homo sapiens (Human)	817	FUNCTION: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:26571211, ECO:0000305}.		phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; plasma membrane [GO:0005886]		actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825}; Lipid-anchor {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825}. Cytoplasm, cytosol {ECO:0000269|PubMed:25380825}. Note=Palmitoylation anchors the protein to the plasma membrane (PubMed:23229899, PubMed:25380825). A small amount is observed in the cytosol (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825}.
Q9Y2G1	reviewed	MYRF_HUMAN	Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal]	MYRF C11orf9 KIAA0954 MRF	Homo sapiens (Human)	1151	FUNCTION: [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832). {ECO:0000269|PubMed:23966832}.; FUNCTION: [Myelin regulatory factor, C-terminal]: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. {ECO:0000269|PubMed:23966832}.; FUNCTION: [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832). {ECO:0000269|PubMed:23966832}.		central nervous system myelin maintenance [GO:0032286]; central nervous system myelination [GO:0022010]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; protein autoprocessing [GO:0016540]; response to cocaine [GO:0042220]; response to immobilization stress [GO:0035902]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; sequence-specific DNA binding [GO:0043565]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; sequence-specific DNA binding [GO:0043565]; central nervous system myelin maintenance [GO:0032286]; central nervous system myelination [GO:0022010]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; protein autoprocessing [GO:0016540]; response to cocaine [GO:0042220]; response to immobilization stress [GO:0035902]	SUBCELLULAR LOCATION: [Myelin regulatory factor]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23966832}; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Myelin regulatory factor, N-terminal]: Nucleus {ECO:0000269|PubMed:23966832}. Cytoplasm {ECO:0000269|PubMed:23966832}. Note=Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage. {ECO:0000269|PubMed:23966832}.; SUBCELLULAR LOCATION: [Myelin regulatory factor, C-terminal]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23966832}; Single-pass membrane protein {ECO:0000269|PubMed:23966832}.
Q9Y2G2	reviewed	CARD8_HUMAN	Caspase recruitment domain-containing protein 8 (EC 3.4.-.-) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor up-regulated CARD-containing antagonist of CASP9) (TUCAN) [Cleaved into: Caspase recruitment domain-containing protein 8, C-terminus (CARD8-CT); Caspase recruitment domain-containing protein 8, N-terminus (CARD8-NT)]	CARD8 DACAR KIAA0955 NDPP1	Homo sapiens (Human)	537	FUNCTION: Inflammasome sensor, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis of CD4(+) T-cells and macrophages (PubMed:11821383, PubMed:11408476, PubMed:15030775, PubMed:32840892, PubMed:32051255, PubMed:33542150, PubMed:34019797, PubMed:36357533). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:11821383, PubMed:11408476, PubMed:15030775, PubMed:36357533). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, such as HIV-1 protease activity or Val-boroPro inhibitor, and mediates CARD8 inflammasome activation (PubMed:32840892, PubMed:33542150, PubMed:36357533). In response to pathogen-associated signals, the N-terminal part of CARD8 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (Caspase recruitment domain-containing protein 8, C-terminus), which polymerizes to initiate the formation of the inflammasome complex: the CARD8 inflammasome directly recruits pro-caspase-1 (proCASP1) independently of PYCARD/ASC and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (PubMed:33053349, PubMed:32840892, PubMed:32051255, PubMed:33542150, PubMed:36357533). Ability to sense HIV-1 protease activity leads to the clearance of latent HIV-1 in patient CD4(+) T-cells after viral reactivation; in contrast, HIV-1 can evade CARD8-sensing when its protease remains inactive in infected cells prior to viral budding (PubMed:33542150). Also acts as a negative regulator of the NLRP3 inflammasome (PubMed:24517500). May also act as an inhibitor of NF-kappa-B activation (PubMed:11551959, PubMed:12067710). {ECO:0000269|PubMed:11408476, ECO:0000269|PubMed:11551959, ECO:0000269|PubMed:11821383, ECO:0000269|PubMed:12067710, ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:24517500, ECO:0000269|PubMed:32051255, ECO:0000269|PubMed:32840892, ECO:0000269|PubMed:33053349, ECO:0000269|PubMed:33542150, ECO:0000269|PubMed:34019797, ECO:0000269|PubMed:36357533}.; FUNCTION: [Caspase recruitment domain-containing protein 8]: Constitutes the precursor of the CARD8 inflammasome, which mediates autoproteolytic processing within the FIIND domain to generate the N-terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals. {ECO:0000269|PubMed:22087307}.; FUNCTION: [Caspase recruitment domain-containing protein 8, N-terminus]: Regulatory part that prevents formation of the CARD8 inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, C-terminus), preventing activation of the CARD8 inflammasome (PubMed:33542150). In response to pathogen-associated signals, this part is ubiquitinated by the N-end rule pathway and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the CARD8 inflammasome (Probable) (PubMed:32558991). {ECO:0000269|PubMed:33542150, ECO:0000303|PubMed:32558991, ECO:0000305|PubMed:33053349}.; FUNCTION: [Caspase recruitment domain-containing protein 8, C-terminus]: Constitutes the active part of the CARD8 inflammasome (PubMed:32840892, PubMed:34019797). In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, N-terminus), preventing activation of the CARD8 inflammasome (PubMed:33542150). In response to pathogen-associated signals, the N-terminal part of CARD8 is degraded by the proteasome, releasing this form, which polymerizes to form the CARD8 inflammasome complex: the CARD8 inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis (PubMed:32840892, PubMed:33542150). {ECO:0000269|PubMed:32840892, ECO:0000269|PubMed:33542150, ECO:0000269|PubMed:34019797}.		antiviral innate immune response [GO:0140374]; CARD8 inflammasome complex assembly [GO:0140633]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of interleukin-1 beta production [GO:0032731]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; self proteolysis [GO:0097264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP3 inflammasome complex [GO:0072559]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	CARD domain binding [GO:0050700]; cysteine-type endopeptidase activator activity [GO:0140608]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; molecular condensate scaffold activity [GO:0140693]; NACHT domain binding [GO:0032089]; pattern recognition receptor activity [GO:0038187]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP3 inflammasome complex [GO:0072559]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; CARD domain binding [GO:0050700]; cysteine-type endopeptidase activator activity [GO:0140608]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; molecular condensate scaffold activity [GO:0140693]; NACHT domain binding [GO:0032089]; pattern recognition receptor activity [GO:0038187]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; antiviral innate immune response [GO:0140374]; CARD8 inflammasome complex assembly [GO:0140633]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of interleukin-1 beta production [GO:0032731]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; self proteolysis [GO:0097264]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:24517500, ECO:0000269|PubMed:33154409}. Nucleus {ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:33154409}.; SUBCELLULAR LOCATION: [Caspase recruitment domain-containing protein 8, C-terminus]: Inflammasome {ECO:0000269|PubMed:32840892, ECO:0000269|PubMed:33420028, ECO:0000269|PubMed:33420033, ECO:0000269|PubMed:33542150}.
Q9Y2G3	reviewed	AT11B_HUMAN	Phospholipid-transporting ATPase IF (EC 7.6.2.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B)	ATP11B ATPIF ATPIR KIAA0956	Homo sapiens (Human)	1177	FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). {ECO:0000269|PubMed:30018401}.		aminophospholipid transport [GO:0015917]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; phospholipid translocation [GO:0045332]	azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; monoatomic ion transmembrane transporter activity [GO:0015075]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine floppase activity [GO:0090556]	azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; monoatomic ion transmembrane transporter activity [GO:0015075]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine floppase activity [GO:0090556]; aminophospholipid transport [GO:0015917]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; phospholipid translocation [GO:0045332]	SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:21914794}; Multi-pass membrane protein. Early endosome {ECO:0000269|PubMed:23585472}. Endoplasmic reticulum {ECO:0000269|PubMed:21914794}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23585472}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:21914794). In the presence of TMEM30A, mainly located in recycling endosomes (PubMed:21914794). {ECO:0000269|PubMed:21914794}.
Q9Y2G5	reviewed	OFUT2_HUMAN	GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2)	POFUT2 C21orf80 FUT13 KIAA0958	Homo sapiens (Human)	429	FUNCTION: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:22588082). O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable) (PubMed:17395588). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13 (PubMed:17395589, PubMed:17395588). The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). {ECO:0000250|UniProtKB:Q8VHI3, ECO:0000269|PubMed:17395588, ECO:0000269|PubMed:17395589, ECO:0000269|PubMed:22588082, ECO:0000305|PubMed:11067851, ECO:0000305|PubMed:16464858}.		fucose metabolic process [GO:0006004]; mesoderm formation [GO:0001707]; positive regulation of protein folding [GO:1903334]; protein O-linked fucosylation [GO:0036066]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of secretion [GO:0051046]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	peptide-O-fucosyltransferase activity [GO:0046922]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; peptide-O-fucosyltransferase activity [GO:0046922]; fucose metabolic process [GO:0006004]; mesoderm formation [GO:0001707]; positive regulation of protein folding [GO:1903334]; protein O-linked fucosylation [GO:0036066]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of secretion [GO:0051046]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:15233996}. Golgi apparatus {ECO:0000269|PubMed:15233996}. Note=Mainly located in the endoplasmic reticulum. {ECO:0000269|PubMed:15233996}.
Q9Y2G8	reviewed	DJC16_HUMAN	DnaJ homolog subfamily C member 16 (Endoplasmic reticulum DNA J domain-containing protein 8) (ER-resident protein ERdj8) (ERdj8)	DNAJC16 ERDJ8 KIAA0962	Homo sapiens (Human)	782	FUNCTION: Plays an important role in regulating the size of autophagosomes during the formation process. {ECO:0000269|PubMed:32492081}.		regulation of autophagosome size [GO:0016243]	endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]; regulation of autophagosome size [GO:0016243]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:32492081}; Single-pass type IV membrane protein {ECO:0000305}.
Q9Y2G9	reviewed	SBNO2_HUMAN	Protein strawberry notch homolog 2	SBNO2 KIAA0963	Homo sapiens (Human)	1366	FUNCTION: Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162). Plays a role as a regulator in the pro-inflammatory cascade (PubMed:18025162). {ECO:0000250|UniProtKB:Q7TNB8, ECO:0000269|PubMed:18025162}.		bone mineralization [GO:0030282]; bone trabecula morphogenesis [GO:0061430]; cellular response to interleukin-11 [GO:0071348]; cellular response to interleukin-6 [GO:0071354]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to lipopolysaccharide [GO:0071222]; macrophage activation involved in immune response [GO:0002281]; negative regulation of DNA-templated transcription [GO:0045892]; osteoclast differentiation [GO:0030316]; osteoclast fusion [GO:0072675]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of inflammatory response [GO:0050727]	nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; histone binding [GO:0042393]	nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; histone binding [GO:0042393]; bone mineralization [GO:0030282]; bone trabecula morphogenesis [GO:0061430]; cellular response to interleukin-11 [GO:0071348]; cellular response to interleukin-6 [GO:0071354]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to lipopolysaccharide [GO:0071222]; macrophage activation involved in immune response [GO:0002281]; negative regulation of DNA-templated transcription [GO:0045892]; osteoclast differentiation [GO:0030316]; osteoclast fusion [GO:0072675]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of inflammatory response [GO:0050727]	
Q9Y2H0	reviewed	DLGP4_HUMAN	Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4)	DLGAP4 DAP4 KIAA0964 SAPAP4	Homo sapiens (Human)	992	FUNCTION: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.		signaling [GO:0023052]	cholinergic synapse [GO:0098981]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic specialization [GO:0099572]	molecular adaptor activity [GO:0060090]	cholinergic synapse [GO:0098981]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic specialization [GO:0099572]; molecular adaptor activity [GO:0060090]; signaling [GO:0023052]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q9Y2H1	reviewed	ST38L_HUMAN	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2)	STK38L KIAA0965 NDR2	Homo sapiens (Human)	464	FUNCTION: Involved in the regulation of structural processes in differentiating and mature neuronal cells. {ECO:0000250, ECO:0000269|PubMed:15037617, ECO:0000269|PubMed:15067004}.		intracellular signal transduction [GO:0035556]; negative regulation of autophagy [GO:0010507]; postsynapse organization [GO:0099173]; protein phosphorylation [GO:0006468]; regulation of cellular component organization [GO:0051128]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]	actin binding [GO:0003779]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; actin binding [GO:0003779]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; negative regulation of autophagy [GO:0010507]; postsynapse organization [GO:0099173]; protein phosphorylation [GO:0006468]; regulation of cellular component organization [GO:0051128]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Note=Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.
Q9Y2H2	reviewed	SAC2_HUMAN	Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2)	INPP5F KIAA0966 SAC2 MSTP007 MSTP047	Homo sapiens (Human)	1132	FUNCTION: Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}.		adult locomotory behavior [GO:0008344]; cardiac muscle hypertrophy in response to stress [GO:0014898]; clathrin-dependent endocytosis [GO:0072583]; negative regulation of axon regeneration [GO:0048681]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of receptor recycling [GO:0001921]; regulation of cell motility [GO:2000145]; regulation of endocytic recycling [GO:2001135]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]	axon [GO:0030424]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; recycling endosome [GO:0055037]	inositol monophosphate 1-phosphatase activity [GO:0008934]; inositol monophosphate 3-phosphatase activity [GO:0052832]; inositol monophosphate 4-phosphatase activity [GO:0052833]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; recycling endosome [GO:0055037]; inositol monophosphate 1-phosphatase activity [GO:0008934]; inositol monophosphate 3-phosphatase activity [GO:0052832]; inositol monophosphate 4-phosphatase activity [GO:0052833]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]; protein homodimerization activity [GO:0042803]; adult locomotory behavior [GO:0008344]; cardiac muscle hypertrophy in response to stress [GO:0014898]; clathrin-dependent endocytosis [GO:0072583]; negative regulation of axon regeneration [GO:0048681]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of receptor recycling [GO:0001921]; regulation of cell motility [GO:2000145]; regulation of endocytic recycling [GO:2001135]; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051896]	SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000269|PubMed:25869669}. Early endosome {ECO:0000269|PubMed:25869669}. Recycling endosome {ECO:0000269|PubMed:25869669}. Note=Also found on macropinosomes. {ECO:0000250|UniProtKB:Q8CDA1}.
Q9Y2H6	reviewed	FND3A_HUMAN	Fibronectin type-III domain-containing protein 3A (Human gene expressed in odontoblasts)	FNDC3A FNDC3 HUGO KIAA0970	Homo sapiens (Human)	1198	FUNCTION: Mediates spermatid-Sertoli adhesion during spermatogenesis. {ECO:0000250}.		cell-cell adhesion [GO:0098609]; fertilization [GO:0009566]; Sertoli cell development [GO:0060009]; spermatid development [GO:0007286]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; vesicle membrane [GO:0012506]	RNA binding [GO:0003723]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; vesicle membrane [GO:0012506]; RNA binding [GO:0003723]; cell-cell adhesion [GO:0098609]; fertilization [GO:0009566]; Sertoli cell development [GO:0060009]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9Y2H9	reviewed	MAST1_HUMAN	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase)	MAST1 KIAA0973 SAST	Homo sapiens (Human)	1570	FUNCTION: Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}.		brain development [GO:0007420]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; brain development [GO:0007420]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9R1L5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9R1L5}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9R1L5}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9R1L5}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1L5}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9R1L5}. Note=Also localized in the soma of neurons. Observed as punctate clusters in the processes of interneurons and along the cell body periphery. Colocalizes with syntrophins at the cell membrane. {ECO:0000250|UniProtKB:Q9R1L5}.
Q9Y2I1	reviewed	NISCH_HUMAN	Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)	NISCH IRAS KIAA0975	Homo sapiens (Human)	1504	FUNCTION: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures. {ECO:0000250, ECO:0000269|PubMed:10882231, ECO:0000269|PubMed:12868002, ECO:0000269|PubMed:15028619, ECO:0000269|PubMed:15028621, ECO:0000269|PubMed:15475348}.		actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; negative regulation of cell migration [GO:0030336]; outer dynein arm assembly [GO:0036158]; Rac protein signal transduction [GO:0016601]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	alpha-tubulin binding [GO:0043014]; dynein heavy chain binding [GO:0045504]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; phosphatidylinositol binding [GO:0035091]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; alpha-tubulin binding [GO:0043014]; dynein heavy chain binding [GO:0045504]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; phosphatidylinositol binding [GO:0035091]; actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; negative regulation of cell migration [GO:0030336]; outer dynein arm assembly [GO:0036158]; Rac protein signal transduction [GO:0016601]	SUBCELLULAR LOCATION: Cell membrane. Cytoplasm. Early endosome. Recycling endosome. Note=Enriched in the early/sorting and recycling endosomes. Colocalized in early/sorting endosomes with EEA1 and SNX2 and in recycling endosomes with transferrin receptor. Detected in the perinuclear region partially associated with punctate structures (By similarity). Colocalizes with PAK1 in cytoplasm, vesicular structures in the perinuclear area and membrane ruffles (By similarity). Colocalizes with RAC1 in the cytoplasm and vesicles structures (By similarity). Colocalized with MAPK1 and MAPK3 in RVLM neurons (By similarity). {ECO:0000250}.
Q9Y2I2	reviewed	NTNG1_HUMAN	Netrin-G1 (Laminet-1)	NTNG1 KIAA0976 LMNT1 UNQ571/PRO1133	Homo sapiens (Human)	539	FUNCTION: Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. {ECO:0000269|PubMed:21946559}.	MISCELLANEOUS: [Isoform 3]: Mostly expressed in adult brain.; MISCELLANEOUS: [Isoform 1]: Hi expression in Expressed in brain and. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Mostly expressed in kidney, also expressed in adult and fetal brain. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: Some expression in fetal brain. {ECO:0000305}.	axonogenesis [GO:0007409]; modulation of chemical synaptic transmission [GO:0050804]; regulation of neuron migration [GO:2001222]; regulation of neuron projection arborization [GO:0150011]; regulation of neuron projection development [GO:0010975]; synaptic membrane adhesion [GO:0099560]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; side of membrane [GO:0098552]	cell adhesion molecule binding [GO:0050839]; cell-cell adhesion mediator activity [GO:0098632]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; side of membrane [GO:0098552]; cell adhesion molecule binding [GO:0050839]; cell-cell adhesion mediator activity [GO:0098632]; axonogenesis [GO:0007409]; modulation of chemical synaptic transmission [GO:0050804]; regulation of neuron migration [GO:2001222]; regulation of neuron projection arborization [GO:0150011]; regulation of neuron projection development [GO:0010975]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21946559}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:21946559}; Extracellular side {ECO:0000269|PubMed:21946559}.
Q9Y2I6	reviewed	NINL_HUMAN	Ninein-like protein	NINL KIAA0980 NLP	Homo sapiens (Human)	1382	FUNCTION: Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}.		microtubule anchoring at centrosome [GO:0034454]	centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]	calcium ion binding [GO:0005509]	centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; calcium ion binding [GO:0005509]; microtubule anchoring at centrosome [GO:0034454]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:26485514}. Cytoplasm {ECO:0000269|PubMed:16254247}. Note=In interphase cells, NINL is transported to the centrosomes by the dynein-dynactin motor complex (PubMed:16254247). During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm (PubMed:16254247).
Q9Y2I7	reviewed	FYV1_HUMAN	1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1)	PIKFYVE KIAA0981 PIP5K3	Homo sapiens (Human)	2098	FUNCTION: Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}.		1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process [GO:1903100]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; intracellular signal transduction [GO:0035556]; melanosome organization [GO:0032438]; myelin assembly [GO:0032288]; neutrophil chemotaxis [GO:0030593]; peptidyl-serine autophosphorylation [GO:0036289]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; phosphatidylinositol 5-phosphate metabolic process [GO:1904562]; phosphatidylinositol biosynthetic process [GO:0006661]; protein localization to nucleus [GO:0034504]; protein targeting to membrane [GO:0006612]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of autophagosome assembly [GO:2000785]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; retrograde transport, endosome to Golgi [GO:0042147]	cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; vesicle membrane [GO:0012506]	1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]	cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; vesicle membrane [GO:0012506]; 1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]; 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process [GO:1903100]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; intracellular signal transduction [GO:0035556]; melanosome organization [GO:0032438]; myelin assembly [GO:0032288]; neutrophil chemotaxis [GO:0030593]; peptidyl-serine autophosphorylation [GO:0036289]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; phosphatidylinositol 5-phosphate metabolic process [GO:1904562]; phosphatidylinositol biosynthetic process [GO:0006661]; protein localization to nucleus [GO:0034504]; protein targeting to membrane [GO:0006612]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of autophagosome assembly [GO:2000785]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:11706043, ECO:0000269|PubMed:17556371}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z1T6}. Early endosome membrane {ECO:0000269|PubMed:30612035}; Peripheral membrane protein. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:30612035}; Peripheral membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:11706043}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z1T6}. Note=Mainly associated with membranes of the late endocytic pathway. {ECO:0000269|PubMed:11706043}.
Q9Y2I8	reviewed	WDR37_HUMAN	WD repeat-containing protein 37	WDR37 KIAA0982	Homo sapiens (Human)	494	FUNCTION: Required for normal ER Ca2+ handling in lymphocytes. Together with PACS1, it plays an essential role in stabilizing peripheral lymphocyte populations. {ECO:0000250|UniProtKB:Q8CBE3}.		corpus callosum development [GO:0022038]; lymphocyte homeostasis [GO:0002260]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; corpus callosum development [GO:0022038]; lymphocyte homeostasis [GO:0002260]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31327510, ECO:0000269|PubMed:34642815}. Nucleus {ECO:0000269|PubMed:31327510}. Note=Primarily localized in the cytoplasm with the highest concentration in the perinuclear region and in small clusters at the leading edge of the spreading cells. {ECO:0000269|PubMed:34642815}.
Q9Y2I9	reviewed	TBC30_HUMAN	TBC1 domain family member 30	TBC1D30 KIAA0984	Homo sapiens (Human)	924	FUNCTION: GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro.		negative regulation of cilium assembly [GO:1902018]; positive regulation of GTPase activity [GO:0043547]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; negative regulation of cilium assembly [GO:1902018]; positive regulation of GTPase activity [GO:0043547]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19077034}; Peripheral membrane protein {ECO:0000269|PubMed:19077034}.
Q9Y2J0	reviewed	RP3A_HUMAN	Rabphilin-3A (Exophilin-1)	RPH3A KIAA0985	Homo sapiens (Human)	694	FUNCTION: Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity). {ECO:0000250|UniProtKB:P47709}.		exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; regulation of calcium ion-dependent exocytosis [GO:0017158]; spontaneous neurotransmitter secretion [GO:0061669]; synaptic vesicle priming [GO:0016082]	cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of membrane [GO:0019898]; extrinsic component of synaptic vesicle membrane [GO:0098850]; neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; inositol 1,4,5 trisphosphate binding [GO:0070679]; phosphate ion binding [GO:0042301]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-containing complex binding [GO:0044877]; selenium binding [GO:0008430]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of membrane [GO:0019898]; extrinsic component of synaptic vesicle membrane [GO:0098850]; neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; inositol 1,4,5 trisphosphate binding [GO:0070679]; phosphate ion binding [GO:0042301]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-containing complex binding [GO:0044877]; selenium binding [GO:0008430]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; regulation of calcium ion-dependent exocytosis [GO:0017158]; spontaneous neurotransmitter secretion [GO:0061669]; synaptic vesicle priming [GO:0016082]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P47709}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P47709}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P47709}. Membrane {ECO:0000250|UniProtKB:P47709}; Peripheral membrane protein {ECO:0000250|UniProtKB:P47709}.
Q9Y2J2	reviewed	E41L3_HUMAN	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]	EPB41L3 DAL1 KIAA0987	Homo sapiens (Human)	1087	FUNCTION: Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.		actomyosin structure organization [GO:0031032]; apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]	cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; juxtaparanode region of axon [GO:0044224]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]	actin binding [GO:0003779]; cytoskeletal protein-membrane anchor activity [GO:0106006]; structural constituent of cytoskeleton [GO:0005200]	cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; juxtaparanode region of axon [GO:0044224]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; cytoskeletal protein-membrane anchor activity [GO:0106006]; structural constituent of cytoskeleton [GO:0005200]; actomyosin structure organization [GO:0031032]; apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction {ECO:0000269|PubMed:9892180}. Cell membrane {ECO:0000269|PubMed:9892180}; Peripheral membrane protein {ECO:0000269|PubMed:9892180}; Cytoplasmic side {ECO:0000269|PubMed:9892180}. Cytoplasm {ECO:0000269|PubMed:9892180}. Note=Detected in the cytoplasm of actively dividing cells.
Q9Y2J4	reviewed	AMOL2_HUMAN	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)	AMOTL2 KIAA0989	Homo sapiens (Human)	779	FUNCTION: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. {ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771}.		actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; hippo signaling [GO:0035329]; regulation of cell migration [GO:0030334]; Wnt signaling pathway [GO:0016055]	bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]		bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; hippo signaling [GO:0035329]; regulation of cell migration [GO:0030334]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Recycling endosome {ECO:0000250}.
Q9Y2J8	reviewed	PADI2_HUMAN	Protein-arginine deiminase type-2 (EC 3.5.3.15) (PAD-H19) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II)	PADI2 KIAA0994 PAD2 PDI2	Homo sapiens (Human)	665	FUNCTION: Catalyzes the deimination of arginine residues of proteins. {ECO:0000269|PubMed:12392711, ECO:0000269|PubMed:25621824, ECO:0000269|PubMed:30044909}.		cellular response to leukemia inhibitory factor [GO:1990830]; chromatin remodeling [GO:0006338]; intracellular estrogen receptor signaling pathway [GO:0030520]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of lymphocyte chemotaxis [GO:1901624]; substantia nigra development [GO:0021762]; transcription initiation-coupled chromatin remodeling [GO:0045815]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; histone arginine deiminase activity [GO:0140794]; histone H3R26 arginine deiminase activity [GO:0140798]; nuclear estrogen receptor binding [GO:0030331]; protein homodimerization activity [GO:0042803]; protein-arginine deiminase activity [GO:0004668]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; histone arginine deiminase activity [GO:0140794]; histone H3R26 arginine deiminase activity [GO:0140798]; nuclear estrogen receptor binding [GO:0030331]; protein homodimerization activity [GO:0042803]; protein-arginine deiminase activity [GO:0004668]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin remodeling [GO:0006338]; intracellular estrogen receptor signaling pathway [GO:0030520]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of lymphocyte chemotaxis [GO:1901624]; substantia nigra development [GO:0021762]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12392711}.
Q9Y2K1	reviewed	ZBTB1_HUMAN	Zinc finger and BTB domain-containing protein 1	ZBTB1 KIAA0997	Homo sapiens (Human)	713	FUNCTION: Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). {ECO:0000250|UniProtKB:Q91VL9, ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167, ECO:0000269|PubMed:24657165}.		B cell differentiation [GO:0030183]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of pro-T cell differentiation [GO:2000176]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T cell mediated immunity [GO:0002711]; protein homooligomerization [GO:0051260]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]; translesion synthesis [GO:0019985]	nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; B cell differentiation [GO:0030183]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of pro-T cell differentiation [GO:2000176]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T cell mediated immunity [GO:0002711]; protein homooligomerization [GO:0051260]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]; translesion synthesis [GO:0019985]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21706167}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20797634}. Note=Localized in dot-like structures in the nucleus (PubMed:21706167). Colocalized with SMRT in nuclear bodies (PubMed:20797634). The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies(PubMed:20797634). {ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167}.
Q9Y2K2	reviewed	SIK3_HUMAN	Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)	SIK3 KIAA0999 QSK L19	Homo sapiens (Human)	1321	FUNCTION: Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q6P4S6, ECO:0000269|PubMed:30232230, ECO:0000305|PubMed:29211348}.		intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16306228}. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ. {ECO:0000269|PubMed:16306228}.
Q9Y2K3	reviewed	MYH15_HUMAN	Myosin-15 (Myosin heavy chain 15)	MYH15 KIAA1000	Homo sapiens (Human)	1946	FUNCTION: Muscle contraction. {ECO:0000250}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]	SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Q9Y2K5	reviewed	R3HD2_HUMAN	R3H domain-containing protein 2	R3HDM2 KIAA1002	Homo sapiens (Human)	976				nucleus [GO:0005634]	RNA binding [GO:0003723]	nucleus [GO:0005634]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y2K6	reviewed	UBP20_HUMAN	Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)	USP20 KIAA1003 LSFR3A VDU2	Homo sapiens (Human)	914	FUNCTION: Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2)(PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}.		antiviral innate immune response [GO:0140374]; endocytosis [GO:0006897]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of autophagy [GO:0010508]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; G protein-coupled receptor binding [GO:0001664]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; G protein-coupled receptor binding [GO:0001664]; zinc ion binding [GO:0008270]; antiviral innate immune response [GO:0140374]; endocytosis [GO:0006897]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of autophagy [GO:0010508]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8C6M1}. Endoplasmic reticulum {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:33792613}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23486064}.
Q9Y2K7	reviewed	KDM2A_HUMAN	Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A)	KDM2A CXXC8 FBL11 FBL7 FBXL11 JHDM1A KIAA1004	Homo sapiens (Human)	1162	FUNCTION: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}.		circadian regulation of gene expression [GO:0032922]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of transcription by competitive promoter binding [GO:0010944]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]	histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; transcription coregulator activity [GO:0003712]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; transcription coregulator activity [GO:0003712]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]; circadian regulation of gene expression [GO:0032922]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of transcription by competitive promoter binding [GO:0010944]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}. Chromosome {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region (PubMed:19001877, PubMed:20417597). Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2 (PubMed:19001877, PubMed:20417597). {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}.
Q9Y2K9	reviewed	STB5L_HUMAN	Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2)	STXBP5L KIAA1006 LLGL4	Homo sapiens (Human)	1186	FUNCTION: Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045). {ECO:0000250|UniProtKB:Q5DQR4, ECO:0000269|PubMed:25504045}.		exocytosis [GO:0006887]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of protein secretion [GO:0050708]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]	GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; syntaxin binding [GO:0019905]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; syntaxin binding [GO:0019905]; exocytosis [GO:0006887]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of protein secretion [GO:0050708]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. {ECO:0000305}.
Q9Y2L1	reviewed	RRP44_HUMAN	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)	DIS3 KIAA1008 RRP44	Homo sapiens (Human)	958	FUNCTION: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. {ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20531386}.	MISCELLANEOUS: The association of DIS3 with the RNA exosome complex appears to be weak explaining its absence in some complex purifications.	CUT catabolic process [GO:0071034]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; membrane [GO:0016020]; nuclear exosome (RNase complex) [GO:0000176]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	3'-5'-RNA exonuclease activity [GO:0000175]; endonuclease activity [GO:0004519]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; membrane [GO:0016020]; nuclear exosome (RNase complex) [GO:0000176]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5'-RNA exonuclease activity [GO:0000175]; endonuclease activity [GO:0004519]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]; CUT catabolic process [GO:0071034]; exonucleolytic catabolism of deadenylated mRNA [GO:0043928]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20531386}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20531389}. Nucleus {ECO:0000269|PubMed:20531386}. Note=Predominantly located in the nucleus (PubMed:20531386). According to PubMed:12429849, found in the nucleolus (PubMed:12429849). According to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3 (PubMed:20531386). {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20531386}.
Q9Y2L5	reviewed	TPPC8_HUMAN	Trafficking protein particle complex subunit 8 (Protein TRS85 homolog)	TRAPPC8 KIAA1012	Homo sapiens (Human)	1435	FUNCTION: Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:26711178}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; vesicle tethering [GO:0099022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
Q9Y2L9	reviewed	LRCH1_HUMAN	Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81)	LRCH1 CHDC1 KIAA1016	Homo sapiens (Human)	728	FUNCTION: Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. {ECO:0000269|PubMed:28028151}.		cellular response to chemokine [GO:1990869]; negative regulation of GTPase activity [GO:0034260]; negative regulation of T cell migration [GO:2000405]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; cellular response to chemokine [GO:1990869]; negative regulation of GTPase activity [GO:0034260]; negative regulation of T cell migration [GO:2000405]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28028151}.
Q9Y2M0	reviewed	FAN1_HUMAN	Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15)	FAN1 KIAA1018 MTMR15	Homo sapiens (Human)	1017	FUNCTION: Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866). {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:20671156, ECO:0000269|PubMed:24981866, ECO:0000269|PubMed:25135477, ECO:0000269|PubMed:25430771}.		DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; nucleotide-excision repair [GO:0006289]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; flap-structured DNA binding [GO:0070336]; magnesium ion binding [GO:0000287]; phosphodiesterase I activity [GO:0004528]; ubiquitin-dependent protein binding [GO:0140036]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; flap-structured DNA binding [GO:0070336]; magnesium ion binding [GO:0000287]; phosphodiesterase I activity [GO:0004528]; ubiquitin-dependent protein binding [GO:0140036]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; nucleotide-excision repair [GO:0006289]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:20671156, ECO:0000269|PubMed:20935496}. Note=Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2 (PubMed:20603015, PubMed:20603016). Localizes to stalled replication forks via its UBZ4-type zinc finger (PubMed:20935496). {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20935496}.
Q9Y2M2	reviewed	SSUH2_HUMAN	Protein SSUH2 homolog (Protein ssu-2 homolog)	SSUH2 C3orf32 FLS485	Homo sapiens (Human)	375	FUNCTION: Plays a role in odontogenesis. {ECO:0000269|PubMed:27680507}.		odontogenesis [GO:0042476]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	heat shock protein binding [GO:0031072]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; heat shock protein binding [GO:0031072]; unfolded protein binding [GO:0051082]; odontogenesis [GO:0042476]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20205943}. Nucleus {ECO:0000269|PubMed:27680507}.
Q9Y2M5	reviewed	KLH20_HUMAN	Kelch-like protein 20 (Kelch-like ECT2-interacting protein) (Kelch-like protein X)	KLHL20 KLEIP KLHLX	Homo sapiens (Human)	609	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486). {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:17395875, ECO:0000269|PubMed:20389280, ECO:0000269|PubMed:21670212, ECO:0000269|PubMed:21840486, ECO:0000269|PubMed:24768539}.		cytoskeleton organization [GO:0007010]; Golgi to endosome transport [GO:0006895]; negative regulation of apoptotic process [GO:0043066]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K33-linked ubiquitination [GO:1990390]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; response to interferon-alpha [GO:0035455]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; trans-Golgi network [GO:0005802]	actin binding [GO:0003779]; type II interferon binding [GO:0019964]; ubiquitin-protein transferase activity [GO:0004842]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; trans-Golgi network [GO:0005802]; actin binding [GO:0003779]; type II interferon binding [GO:0019964]; ubiquitin-protein transferase activity [GO:0004842]; cytoskeleton organization [GO:0007010]; Golgi to endosome transport [GO:0006895]; negative regulation of apoptotic process [GO:0043066]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K33-linked ubiquitination [GO:1990390]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; response to interferon-alpha [GO:0035455]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Nucleus. Golgi apparatus, trans-Golgi network. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination (PubMed:20389280). {ECO:0000269|PubMed:20389280}.
Q9Y2N7	reviewed	HIF3A_HUMAN	Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (Class E basic helix-loop-helix protein 17) (bHLHe17) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7) (PAS domain-containing protein 7)	HIF3A BHLHE17 MOP7 PASD7	Homo sapiens (Human)	669	FUNCTION: Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity). {ECO:0000250|UniProtKB:Q0VBL6, ECO:0000269|PubMed:11573933, ECO:0000269|PubMed:16126907, ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395, ECO:0000269|PubMed:21069422}.; FUNCTION: [Isoform 2]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression. {ECO:0000269|PubMed:11573933}.; FUNCTION: [Isoform 3]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. {ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395, ECO:0000269|PubMed:21069422}.; FUNCTION: [Isoform 4]: Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:16126907, PubMed:17998805, PubMed:19694616, PubMed:20416395). May act as a tumor suppressor and inhibits malignant cell transformation (PubMed:17998805). {ECO:0000269|PubMed:16126907, ECO:0000269|PubMed:17998805, ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395}.; FUNCTION: [Isoform 5]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. {ECO:0000269|PubMed:21069422}.	MISCELLANEOUS: [Isoform 5]: Incomplete sequence. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Incomplete sequence. {ECO:0000305}.	angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16775626, ECO:0000269|PubMed:19694616}. Cytoplasm {ECO:0000269|PubMed:19694616}. Nucleus speckle {ECO:0000250|UniProtKB:Q0VBL6}. Mitochondrion {ECO:0000250|UniProtKB:Q0VBL6}. Note=In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes with BAD in the cytoplasm. Colocalizes with EPAS1 and HIF1A in the nucleus and speckles (By similarity). Localized in the cytoplasm and nuclei under normoxia, but increased in the nucleus under hypoxic conditions (PubMed:19694616). Colocalized with HIF1A in kidney tumors (PubMed:19694616). {ECO:0000250|UniProtKB:Q0VBL6, ECO:0000250|UniProtKB:Q9JHS2, ECO:0000269|PubMed:19694616}.
Q9Y2P0	reviewed	ZN835_HUMAN	Zinc finger protein 835	ZNF835	Homo sapiens (Human)	537	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y2P4	reviewed	S27A6_HUMAN	Long-chain fatty acid transport protein 6 (FATP-6) (Fatty acid transport protein 6) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty-acid-coenzyme A ligase, very long-chain 2) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 6) (Very long-chain acyl-CoA synthetase homolog 1) (VLCSH1) (hVLCS-H1) (EC 6.2.1.-)	SLC27A6 ACSVL2 FACVL2 FATP6	Homo sapiens (Human)	619	FUNCTION: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:12556534). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (By similarity). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation such as the heart (PubMed:12556534). {ECO:0000250|UniProtKB:E9Q9W4, ECO:0000269|PubMed:12556534}.		long-chain fatty acid transport [GO:0015909]; very long-chain fatty acid metabolic process [GO:0000038]	plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	arachidonate-CoA ligase activity [GO:0047676]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; oleate transmembrane transporter activity [GO:1901480]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; arachidonate-CoA ligase activity [GO:0047676]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; oleate transmembrane transporter activity [GO:1901480]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; long-chain fatty acid transport [GO:0015909]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000305|PubMed:12556534}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:E9Q9W4}; Multi-pass membrane protein {ECO:0000255}. Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. {ECO:0000305|PubMed:12556534}.
Q9Y2P5	reviewed	S27A5_HUMAN	Long-chain fatty acid transport protein 5 (FATP-5) (Fatty acid transport protein 5) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Bile acyl-CoA synthetase) (BACS) (EC 6.2.1.7) (Cholate--CoA ligase) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (EC 6.2.1.-) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)	SLC27A5 ACSB ACSVL6 FACVL3 FATP5	Homo sapiens (Human)	690	FUNCTION: May mediate the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (PubMed:20448275, PubMed:20530735). Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:10479480). Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:10749848, PubMed:11980911). Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed:10749848, PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity). {ECO:0000250|UniProtKB:Q4LDG0, ECO:0000269|PubMed:10479480, ECO:0000269|PubMed:10749848, ECO:0000269|PubMed:11980911, ECO:0000269|PubMed:20448275, ECO:0000269|PubMed:20530735}.		bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; establishment of localization in cell [GO:0051649]; ketone body biosynthetic process [GO:0046951]; long-chain fatty acid import across plasma membrane [GO:0015911]; triglyceride mobilization [GO:0006642]; very long-chain fatty acid metabolic process [GO:0000038]	basal plasma membrane [GO:0009925]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; cholate-CoA ligase activity [GO:0047747]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oxidoreductase activity [GO:0016491]; protein-containing complex binding [GO:0044877]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	basal plasma membrane [GO:0009925]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; cholate-CoA ligase activity [GO:0047747]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oxidoreductase activity [GO:0016491]; protein-containing complex binding [GO:0044877]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; establishment of localization in cell [GO:0051649]; ketone body biosynthetic process [GO:0046951]; long-chain fatty acid import across plasma membrane [GO:0015911]; triglyceride mobilization [GO:0006642]; very long-chain fatty acid metabolic process [GO:0000038]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10479480}; Multi-pass membrane protein {ECO:0000255}. Microsome {ECO:0000250|UniProtKB:Q9ES38}. Cell membrane {ECO:0000250|UniProtKB:Q4LDG0}; Multi-pass membrane protein {ECO:0000255}.
Q9Y2P7	reviewed	ZN256_HUMAN	Zinc finger protein 256 (Bone marrow zinc finger 3) (BMZF-3)	ZNF256 BMZF3	Homo sapiens (Human)	627	FUNCTION: Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity. {ECO:0000269|PubMed:18060868}.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18060868}.
Q9Y2P8	reviewed	RCL1_HUMAN	RNA 3'-terminal phosphate cyclase-like protein	RCL1 RNAC RPC2 RPCL1 RTC2 HSPC338	Homo sapiens (Human)	373	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Does not have cyclase activity (By similarity). {ECO:0000250|UniProtKB:Q08096, ECO:0000269|PubMed:34516797}.		endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; ribosomal small subunit biogenesis [GO:0042274]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA endonuclease activity [GO:0004521]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA endonuclease activity [GO:0004521]; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
Q9Y2Q0	reviewed	AT8A1_HUMAN	Phospholipid-transporting ATPase IA (EC 7.6.2.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1)	ATP8A1 ATPIA	Homo sapiens (Human)	1164	FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:31416931). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed:31416931). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity). Acts as aminophospholipid translocase at the cell membrane in neuronal cells (By similarity). {ECO:0000250|UniProtKB:P70704, ECO:0000269|PubMed:31416931}.		aminophospholipid translocation [GO:0140331]; learning [GO:0007612]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]; positive regulation of cell migration [GO:0030335]; positive regulation of phospholipid translocation [GO:0061092]; transport across blood-brain barrier [GO:0150104]	azurophil granule membrane [GO:0035577]; chromaffin granule membrane [GO:0042584]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; organelle membrane [GO:0031090]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; magnesium ion binding [GO:0000287]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556]	azurophil granule membrane [GO:0035577]; chromaffin granule membrane [GO:0042584]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; organelle membrane [GO:0031090]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; magnesium ion binding [GO:0000287]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556]; aminophospholipid translocation [GO:0140331]; learning [GO:0007612]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]; positive regulation of cell migration [GO:0030335]; positive regulation of phospholipid translocation [GO:0061092]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P70704}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P70704}. Cytoplasmic granule {ECO:0000269|PubMed:20947505}. Cell membrane {ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:21914794}. Endoplasmic reticulum {ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:21914794}. Golgi apparatus {ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:21914794}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:20947505). In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures and localizes to the cell membrane (PubMed:20947505). Localizes to plasma membranes of red blood cells (By similarity). {ECO:0000250|UniProtKB:P70704, ECO:0000269|PubMed:20947505}.
Q9Y2Q3	reviewed	GSTK1_HUMAN	Glutathione S-transferase kappa 1 (EC 2.5.1.18) (GST 13-13) (GST class-kappa) (GSTK1-1) (hGSTK1) (Glutathione S-transferase subunit 13)	GSTK1 HDCMD47P	Homo sapiens (Human)	226	FUNCTION: Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds (PubMed:14709161, PubMed:14742434). Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB) (PubMed:14709161). {ECO:0000269|PubMed:14709161, ECO:0000269|PubMed:14742434}.		epithelial cell differentiation [GO:0030855]; glutathione metabolic process [GO:0006749]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; epithelial cell differentiation [GO:0030855]; glutathione metabolic process [GO:0006749]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:14742434}.
Q9Y2Q5	reviewed	LTOR2_HUMAN	Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (MAPBP-interacting protein) (Roadblock domain-containing protein 3)	LAMTOR2 MAPBPIP ROBLD3 HSPC003	Homo sapiens (Human)	125	FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:29123114, PubMed:29158492, PubMed:29107538, PubMed:28935770). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:30181260, PubMed:29123114, PubMed:29158492, PubMed:29107538, PubMed:28935770). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:29123114, PubMed:29158492, PubMed:29107538). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity). {ECO:0000250|UniProtKB:Q9JHS3, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:30181260}.		cellular response to amino acid stimulus [GO:0071230]; fibroblast migration [GO:0010761]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; protein localization to cell junction [GO:1902414]; regulation of cell growth [GO:0001558]; regulation of cell-substrate junction organization [GO:0150116]; TORC1 signaling [GO:0038202]	endosome membrane [GO:0010008]; FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; Ragulator complex [GO:0071986]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]	guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090]	endosome membrane [GO:0010008]; FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; Ragulator complex [GO:0071986]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090]; cellular response to amino acid stimulus [GO:0071230]; fibroblast migration [GO:0010761]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; protein localization to cell junction [GO:1902414]; regulation of cell growth [GO:0001558]; regulation of cell-substrate junction organization [GO:0150116]; TORC1 signaling [GO:0038202]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q9JHS3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JHS3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JHS3}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JHS3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JHS3}. Note=Recruited to lysosome and endosome membranes by LAMTOR1. {ECO:0000250|UniProtKB:Q9JHS3}.
Q9Y2R0	reviewed	COA3_HUMAN	Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (Coiled-coil domain-containing protein 56) (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa)	COA3 CCDC56 MITRAC12 HSPC009	Homo sapiens (Human)	106	FUNCTION: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. {ECO:0000269|PubMed:23260140}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]; positive regulation of mitochondrial translation [GO:0070131]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; positive regulation of mitochondrial translation [GO:0070131]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:23260140}; Single-pass membrane protein {ECO:0000269|PubMed:23260140}.
Q9Y2R2	reviewed	PTN22_HUMAN	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)	PTPN22 PTPN8	Homo sapiens (Human)	807	FUNCTION: Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). {ECO:0000250|UniProtKB:P29352, ECO:0000269|PubMed:16461343, ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208, ECO:0000269|PubMed:23991106, ECO:0000269|PubMed:27043286}.	MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 6]: Lacks most of the phosphatase domain and functions as a dominant negative isoform of the full length PTPN22. {ECO:0000305}.	autophagy [GO:0006914]; cellular response to muramyl dipeptide [GO:0071225]; lipid metabolic process [GO:0006629]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of autophagy [GO:0010507]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; phosphoanandamide dephosphorylation [GO:0035644]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of granzyme B production [GO:0071663]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type II interferon production [GO:0032729]; protein dephosphorylation [GO:0006470]; regulation of B cell receptor signaling pathway [GO:0050855]; regulation of innate immune response [GO:0045088]; regulation of natural killer cell proliferation [GO:0032817]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to lipopolysaccharide [GO:0032496]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	kinase binding [GO:0019900]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; kinase binding [GO:0019900]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase binding [GO:0031625]; autophagy [GO:0006914]; cellular response to muramyl dipeptide [GO:0071225]; lipid metabolic process [GO:0006629]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of autophagy [GO:0010507]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; phosphoanandamide dephosphorylation [GO:0035644]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of granzyme B production [GO:0071663]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type II interferon production [GO:0032729]; protein dephosphorylation [GO:0006470]; regulation of B cell receptor signaling pathway [GO:0050855]; regulation of innate immune response [GO:0045088]; regulation of natural killer cell proliferation [GO:0032817]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to lipopolysaccharide [GO:0032496]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P29352}.
Q9Y2R4	reviewed	DDX52_HUMAN	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.4.13) (ATP-dependent RNA helicase ROK1-like) (DEAD box protein 52)	DDX52 ROK1 HUSSY-19	Homo sapiens (Human)	599	FUNCTION: Required for efficient ribosome biogenesis (By similarity). May control cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as GTPBP4 (By similarity). {ECO:0000250|UniProtKB:Q9VVK8}.		maturation of SSU-rRNA [GO:0030490]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; maturation of SSU-rRNA [GO:0030490]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Q9Y2S2	reviewed	CRYL1_HUMAN	Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH)	CRYL1 CRY	Homo sapiens (Human)	319	FUNCTION: Has high L-gulonate 3-dehydrogenase activity. It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate. {ECO:0000269|PubMed:15809331}.		fatty acid metabolic process [GO:0006631]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	L-gulonate 3-dehydrogenase activity [GO:0050104]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; L-gulonate 3-dehydrogenase activity [GO:0050104]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]; fatty acid metabolic process [GO:0006631]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P14755}.
Q9Y2S7	reviewed	PDIP2_HUMAN	Polymerase delta-interacting protein 2 (38 kDa DNA polymerase delta interaction protein) (p38)	POLDIP2 PDIP38 POLD4 HSPC017	Homo sapiens (Human)	368	FUNCTION: Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025). May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527). {ECO:0000269|PubMed:24191025, ECO:0000269|PubMed:26984527}.		error-free translesion synthesis [GO:0070987]; mitochondrion morphogenesis [GO:0070584]; mitotic spindle assembly [GO:0090307]; negative regulation of macroautophagy [GO:0016242]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cytokinesis [GO:1903490]; vascular associated smooth muscle cell proliferation [GO:1990874]	cell-cell junction [GO:0005911]; midbody [GO:0030496]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]	DNA binding [GO:0003677]	cell-cell junction [GO:0005911]; midbody [GO:0030496]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; DNA binding [GO:0003677]; error-free translesion synthesis [GO:0070987]; mitochondrion morphogenesis [GO:0070584]; mitotic spindle assembly [GO:0090307]; negative regulation of macroautophagy [GO:0016242]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cytokinesis [GO:1903490]; vascular associated smooth muscle cell proliferation [GO:1990874]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:16428295}. Nucleus {ECO:0000269|PubMed:16428295}. Note=Mainly localizes to the mitochondrial matrix; a small fraction localizes in the nucleus. {ECO:0000269|PubMed:16428295}.
Q9Y2T1	reviewed	AXIN2_HUMAN	Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)	AXIN2	Homo sapiens (Human)	843	FUNCTION: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. {ECO:0000250|UniProtKB:O15169}.		aortic valve morphogenesis [GO:0003180]; bone mineralization [GO:0030282]; cell development [GO:0048468]; cellular response to dexamethasone stimulus [GO:0071549]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; intramembranous ossification [GO:0001957]; maintenance of DNA repeat elements [GO:0043570]; mitral valve morphogenesis [GO:0003183]; mRNA stabilization [GO:0048255]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000054]; odontogenesis [GO:0042476]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein localization [GO:0008104]; regulation of centromeric sister chromatid cohesion [GO:0070602]; regulation of chondrocyte development [GO:0061181]; regulation of extracellular matrix organization [GO:1903053]; regulation of mismatch repair [GO:0032423]; secondary heart field specification [GO:0003139]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; Wnt signaling pathway [GO:0016055]	beta-catenin destruction complex [GO:0030877]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; I-SMAD binding [GO:0070411]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625]	beta-catenin destruction complex [GO:0030877]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; I-SMAD binding [GO:0070411]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625]; aortic valve morphogenesis [GO:0003180]; bone mineralization [GO:0030282]; cell development [GO:0048468]; cellular response to dexamethasone stimulus [GO:0071549]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; intramembranous ossification [GO:0001957]; maintenance of DNA repeat elements [GO:0043570]; mitral valve morphogenesis [GO:0003183]; mRNA stabilization [GO:0048255]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000054]; odontogenesis [GO:0042476]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein localization [GO:0008104]; regulation of centromeric sister chromatid cohesion [GO:0070602]; regulation of chondrocyte development [GO:0061181]; regulation of extracellular matrix organization [GO:1903053]; regulation of mismatch repair [GO:0032423]; secondary heart field specification [GO:0003139]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21383061}.
Q9Y2T2	reviewed	AP3M1_HUMAN	AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin)	AP3M1	Homo sapiens (Human)	418	FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.		anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; endocytosis [GO:0006897]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; protein targeting to lysosome [GO:0006622]; vesicle-mediated transport [GO:0016192]	AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin adaptor complex [GO:0030131]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]	small GTPase binding [GO:0031267]	AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin adaptor complex [GO:0030131]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; small GTPase binding [GO:0031267]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; endocytosis [GO:0006897]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; protein targeting to lysosome [GO:0006622]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Q9Y2T3	reviewed	GUAD_HUMAN	Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) (p51-nedasin)	GDA KIAA1258	Homo sapiens (Human)	454	FUNCTION: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. {ECO:0000269|PubMed:10075721, ECO:0000269|PubMed:22662200}.		allantoin metabolic process [GO:0000255]; amide catabolic process [GO:0043605]; deoxyguanosine catabolic process [GO:0006161]; dGMP catabolic process [GO:0046055]; GMP catabolic process [GO:0046038]; guanine catabolic process [GO:0006147]; guanine metabolic process [GO:0046098]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]	cytosol [GO:0005829]	guanine deaminase activity [GO:0008892]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; guanine deaminase activity [GO:0008892]; zinc ion binding [GO:0008270]; allantoin metabolic process [GO:0000255]; amide catabolic process [GO:0043605]; deoxyguanosine catabolic process [GO:0006161]; dGMP catabolic process [GO:0046055]; GMP catabolic process [GO:0046038]; guanine catabolic process [GO:0006147]; guanine metabolic process [GO:0046098]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]	
Q9Y2T6	reviewed	GPR55_HUMAN	G-protein coupled receptor 55	GPR55	Homo sapiens (Human)	319	FUNCTION: May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. {ECO:0000250, ECO:0000269|PubMed:19805329}.	MISCELLANEOUS: The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.	activation of phospholipase C activity [GO:0007202]; bone resorption [GO:0045453]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of osteoclast differentiation [GO:0045671]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of Rho protein signal transduction [GO:0035025]	plasma membrane [GO:0005886]	cannabinoid receptor activity [GO:0004949]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; cannabinoid receptor activity [GO:0004949]; G protein-coupled receptor activity [GO:0004930]; activation of phospholipase C activity [GO:0007202]; bone resorption [GO:0045453]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of osteoclast differentiation [GO:0045671]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of Rho protein signal transduction [GO:0035025]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18757503}; Multi-pass membrane protein {ECO:0000269|PubMed:18757503}.
Q9Y2T7	reviewed	YBOX2_HUMAN	Y-box-binding protein 2 (Contrin) (DNA-binding protein C) (Dbpc) (Germ cell-specific Y-box-binding protein) (MSY2 homolog)	YBX2 CSDA3 MSY2	Homo sapiens (Human)	364	FUNCTION: Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity). {ECO:0000250|UniProtKB:Q9Z2C8}.		oocyte development [GO:0048599]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]; translational attenuation [GO:0009386]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; oocyte development [GO:0048599]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]; translational attenuation [GO:0009386]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16479255}. Nucleus {ECO:0000269|PubMed:16479255}.
Q9Y2U5	reviewed	M3K2_HUMAN	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)	MAP3K2 MAPKKK2 MEKK2	Homo sapiens (Human)	619	FUNCTION: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}.		cellular response to mechanical stimulus [GO:0071260]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cellular response to mechanical stimulus [GO:0071260]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15075238}. Nucleus {ECO:0000269|PubMed:15075238}. Note=Upon EGF stimulation, translocates into the nucleus.
Q9Y2U8	reviewed	MAN1_HUMAN	Inner nuclear membrane protein Man1 (LEM domain-containing protein 3)	LEMD3 MAN1	Homo sapiens (Human)	911	FUNCTION: Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.		negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]	DNA binding [GO:0003677]; U1 snRNP binding [GO:1990446]	membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; DNA binding [GO:0003677]; U1 snRNP binding [GO:1990446]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:15647271}; Multi-pass membrane protein {ECO:0000269|PubMed:15647271}.
Q9Y2U9	reviewed	KLDC2_HUMAN	Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)	KLHDC2 HCA33	Homo sapiens (Human)	406	FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578, PubMed:30526872). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:29775578, PubMed:30526872). The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578, PubMed:30526872). The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine (PubMed:26138980, PubMed:30526872). The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation (PubMed:29775578, PubMed:30526872). May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding (PubMed:11384994). {ECO:0000269|PubMed:11384994, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30526872}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	Cul2-RING ubiquitin ligase complex [GO:0031462]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11384994, ECO:0000269|PubMed:16964437}.
Q9Y2V0	reviewed	CDIN1_HUMAN	CDAN1-interacting nuclease 1 (Protein HH114)	CDIN1 C15orf41	Homo sapiens (Human)	281	FUNCTION: Plays a role in erythroid cell differentiation. {ECO:0000269|PubMed:31191338}.		erythrocyte differentiation [GO:0030218]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; erythrocyte differentiation [GO:0030218]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31191338}. Cytoplasm {ECO:0000269|PubMed:31191338}. Note=Mainly nuclear. {ECO:0000269|PubMed:31191338}.
Q9Y2V2	reviewed	CHSP1_HUMAN	Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24)	CARHSP1	Homo sapiens (Human)	147	FUNCTION: Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). {ECO:0000269|PubMed:21078874, ECO:0000269|PubMed:21177848}.		intracellular signal transduction [GO:0035556]; regulation of mRNA stability [GO:0043488]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; P granule [GO:0043186]; P-body [GO:0000932]	mRNA 3'-UTR binding [GO:0003730]; phosphatase binding [GO:0019902]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; P granule [GO:0043186]; P-body [GO:0000932]; mRNA 3'-UTR binding [GO:0003730]; phosphatase binding [GO:0019902]; intracellular signal transduction [GO:0035556]; regulation of mRNA stability [GO:0043488]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21177848}. Cytoplasm, P-body {ECO:0000269|PubMed:21177848}. Cytoplasmic granule {ECO:0000269|PubMed:21177848}. Note=Detected at cytoplasmic stress granules and P-bodies. Detected at exosome granules where mRNA is degraded (By similarity). {ECO:0000250}.
Q9Y2V3	reviewed	RX_HUMAN	Retinal homeobox protein Rx (Retina and anterior neural fold homeobox protein)	RAX RX	Homo sapiens (Human)	346	FUNCTION: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter.		camera-type eye development [GO:0043010]; hypothalamus development [GO:0021854]; limb development [GO:0060173]; pattern specification process [GO:0007389]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; camera-type eye development [GO:0043010]; hypothalamus development [GO:0021854]; limb development [GO:0060173]; pattern specification process [GO:0007389]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus.
Q9Y2V7	reviewed	COG6_HUMAN	Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6)	COG6 KIAA1134	Homo sapiens (Human)	657	FUNCTION: Required for normal Golgi function. {ECO:0000250}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588]		Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588]; glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q9Y2W1	reviewed	TR150_HUMAN	Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)	THRAP3 BCLAF2 TRAP150	Homo sapiens (Human)	955	FUNCTION: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}.		circadian rhythm [GO:0007623]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	extracellular exosome [GO:0070062]; mediator complex [GO:0016592]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; phosphoprotein binding [GO:0051219]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	extracellular exosome [GO:0070062]; mediator complex [GO:0016592]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; phosphoprotein binding [GO:0051219]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; circadian rhythm [GO:0007623]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:23525231}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24100041}. Nucleus speckle {ECO:0000269|PubMed:24100041}.
Q9Y2W2	reviewed	WBP11_HUMAN	WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1)	WBP11 NPWBP SIPP1 SNP70	Homo sapiens (Human)	641	FUNCTION: Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; WW domain binding [GO:0050699]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; WW domain binding [GO:0050699]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin.
Q9Y2W3	reviewed	S45A1_HUMAN	Proton-associated sugar transporter A (PAST-A) (Deleted in neuroblastoma 5 protein) (DNb-5) (Solute carrier family 45 member 1)	SLC45A1 DNB5	Homo sapiens (Human)	782	FUNCTION: Proton-associated glucose transporter in the brain. {ECO:0000269|PubMed:28434495}.		galactose transmembrane transport [GO:0015757]; glucose transmembrane transport [GO:1904659]	membrane [GO:0016020]	galactose:proton symporter activity [GO:0015517]; glucose:proton symporter activity [GO:0005356]; sucrose:proton symporter activity [GO:0008506]	membrane [GO:0016020]; galactose:proton symporter activity [GO:0015517]; glucose:proton symporter activity [GO:0005356]; sucrose:proton symporter activity [GO:0008506]; galactose transmembrane transport [GO:0015757]; glucose transmembrane transport [GO:1904659]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:28434495}; Multi-pass membrane protein {ECO:0000255}.
Q9Y2W6	reviewed	TDRKH_HUMAN	Tudor and KH domain-containing protein (Tudor domain-containing protein 2)	TDRKH TDRD2	Homo sapiens (Human)	561	FUNCTION: Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules. {ECO:0000250|UniProtKB:Q80VL1}.		fertilization [GO:0009566]; male meiotic nuclear division [GO:0007140]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]	mitochondrion [GO:0005739]; P granule [GO:0043186]; pi-body [GO:0071546]; piP-body [GO:0071547]	RNA binding [GO:0003723]	mitochondrion [GO:0005739]; P granule [GO:0043186]; pi-body [GO:0071546]; piP-body [GO:0071547]; RNA binding [GO:0003723]; fertilization [GO:0009566]; male meiotic nuclear division [GO:0007140]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q80VL1}. Mitochondrion {ECO:0000250|UniProtKB:Q80VL1}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Colocalizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs. Associated with mitochondria in the germline. {ECO:0000250|UniProtKB:Q80VL1}.
Q9Y2W7	reviewed	CSEN_HUMAN	Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3)	KCNIP3 CSEN DREAM KCHIP3	Homo sapiens (Human)	256	FUNCTION: Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). {ECO:0000250|UniProtKB:Q9QXT8}.; FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. {ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:15485870, ECO:0000269|PubMed:16123112, ECO:0000269|PubMed:18957440}.; FUNCTION: May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. {ECO:0000269|PubMed:11259376, ECO:0000269|PubMed:11988022, ECO:0000269|PubMed:9771752}.		apoptotic process [GO:0006915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transmembrane transport [GO:1901379]; signal transduction [GO:0007165]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	calcium ion binding [GO:0005509]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; voltage-gated monoatomic ion channel activity [GO:0005244]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; calcium ion binding [GO:0005509]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; voltage-gated monoatomic ion channel activity [GO:0005244]; apoptotic process [GO:0006915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transmembrane transport [GO:1901379]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18957440}. Cell membrane {ECO:0000269|PubMed:15485870, ECO:0000269|PubMed:18957440}; Lipid-anchor {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:11278424, ECO:0000269|PubMed:18957440}. Golgi apparatus {ECO:0000269|PubMed:11278424}. Nucleus {ECO:0000269|PubMed:21070824}. Note=Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. {ECO:0000269|PubMed:11278424, ECO:0000269|PubMed:15485870, ECO:0000269|PubMed:21070824}.
Q9Y2X0	reviewed	MED16_HUMAN	Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92)	MED16 DRIP92 THRAP5	Homo sapiens (Human)	877	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:10198638, ECO:0000269|PubMed:10235266}.		positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y2X3	reviewed	NOP58_HUMAN	Nucleolar protein 58 (Nucleolar protein 5)	NOP58 NOL5 NOP5 HSPC120	Homo sapiens (Human)	529	FUNCTION: Required for 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283, ECO:0000269|PubMed:34516797}.		ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; snoRNA localization [GO:0048254]	box C/D RNP complex [GO:0031428]; Cajal body [GO:0015030]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pre-snoRNP complex [GO:0070761]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]	ATPase binding [GO:0051117]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; TFIID-class transcription factor complex binding [GO:0001094]	box C/D RNP complex [GO:0031428]; Cajal body [GO:0015030]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pre-snoRNP complex [GO:0070761]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; ATPase binding [GO:0051117]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; TFIID-class transcription factor complex binding [GO:0001094]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; snoRNA localization [GO:0048254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:33367824, ECO:0000269|PubMed:34516797}. Nucleus, nucleoplasm {ECO:0000269|PubMed:33367824}. Note=Localizes to the nucleolus with a minor part present in the nucleoplasm. {ECO:0000269|PubMed:33367824}.
Q9Y2X7	reviewed	GIT1_HUMAN	ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)	GIT1	Homo sapiens (Human)	761	FUNCTION: GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}.		brain development [GO:0007420]; cell redox homeostasis [GO:0045454]; cellular response to lipopolysaccharide [GO:0071222]; ephrin receptor signaling pathway [GO:0048013]; intramembranous ossification [GO:0001957]; locomotory behavior [GO:0007626]; motor learning [GO:0061743]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of interleukin-1 beta production [GO:0032691]; neuron development [GO:0048666]; positive regulation of microtubule nucleation [GO:0090063]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of ARF protein signal transduction [GO:0032012]; regulation of cytokinesis [GO:0032465]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle recycling [GO:0036465]	calyx of Held [GO:0044305]; centrosome [GO:0005813]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; neuron projection [GO:0043005]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	gamma-tubulin binding [GO:0043015]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]	calyx of Held [GO:0044305]; centrosome [GO:0005813]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; neuron projection [GO:0043005]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; synapse [GO:0045202]; gamma-tubulin binding [GO:0043015]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]; brain development [GO:0007420]; cell redox homeostasis [GO:0045454]; cellular response to lipopolysaccharide [GO:0071222]; ephrin receptor signaling pathway [GO:0048013]; intramembranous ossification [GO:0001957]; locomotory behavior [GO:0007626]; motor learning [GO:0061743]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of interleukin-1 beta production [GO:0032691]; neuron development [GO:0048666]; positive regulation of microtubule nucleation [GO:0090063]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of ARF protein signal transduction [GO:0032012]; regulation of cytokinesis [GO:0032465]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle recycling [GO:0036465]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11896197}. Synapse {ECO:0000269|PubMed:12695502}. Presynapse {ECO:0000250|UniProtKB:Q9Z272}. Postsynapse {ECO:0000250|UniProtKB:Q9Z272}. Postsynaptic density {ECO:0000250|UniProtKB:Q9Z272}. Cell junction, focal adhesion {ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:15923189}. Cell projection, lamellipodium {ECO:0000269|PubMed:11896197}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:27012601}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:27012601}. Note=Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytosolic complexes, containing at least PXN/paxillin, ARHGEF7 and PAK1, and membrane protrusions. During cell migration, moves from the disassembling adhesions into the cytosol and towards the leading edge. In adherent cells, localizes to adhesions. Recruitment to adhesions may be mediated by RAC and active tyrosine-phosphorylated PXN (PubMed:11896197). May be present in both excitatory and inhibitory synapses. In hippocampal neurons, recruitment of GIT1 to synapses is regulated by ephrinB activation and ephrinB downstream effector GRB4/NCK2. In hippocampal neurons, partially colocalizes with PCLO (By similarity). Interaction with GRIN3A limits GIT1 synaptic localization (By similarity). Localization to the centrosome does not depend upon the presence of gamma-tubulin (PubMed:27012601). {ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:27012601}.
Q9Y2X8	reviewed	UB2D4_HUMAN	Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)	UBE2D4 UBCH5D	Homo sapiens (Human)	147	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination. {ECO:0000269|PubMed:20061386}.		protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q9Y2X9	reviewed	ZN281_HUMAN	Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99)	ZNF281 GZP1 ZBP99	Homo sapiens (Human)	895	FUNCTION: Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}.		embryonic body morphogenesis [GO:0010172]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; stem cell differentiation [GO:0048863]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; embryonic body morphogenesis [GO:0010172]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10448078}.
Q9Y2Y0	reviewed	AR2BP_HUMAN	ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) (ARL2-binding protein) (Binder of ARF2 protein 1)	ARL2BP BART BART1	Homo sapiens (Human)	163	FUNCTION: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. {ECO:0000269|PubMed:18234692}.		maintenance of protein location in nucleus [GO:0051457]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; signal transduction [GO:0007165]	centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; midbody [GO:0030496]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; spindle [GO:0005819]	GTPase regulator activity [GO:0030695]; transcription coactivator activity [GO:0003713]	centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; midbody [GO:0030496]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; GTPase regulator activity [GO:0030695]; transcription coactivator activity [GO:0003713]; maintenance of protein location in nucleus [GO:0051457]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body. Note=The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. In retina photoreceptor cells, localized in the distal connecting cilia, basal body, ciliary-associated centriole, and ciliary rootlet. Interaction with ARL2 may be required for cilia basal body localization. {ECO:0000250}.
Q9Y2Y1	reviewed	RPC10_HUMAN	DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III 12.5 kDa subunit) (RPC12.5) (RNA polymerase III subunit C11) (HsC11p) (RPC11) (hRPC11)	POLR3K RPC11 My010	Homo sapiens (Human)	108	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170). Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:12391170, PubMed:30584594). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses (PubMed:19631370, PubMed:19609254). Acts as nuclear and cytosolic DNA sensor involved in innate immune response (PubMed:19631370, PubMed:19609254). Can sense non-self dsDNA that serves as template for transcription into dsRNA (PubMed:19631370, PubMed:19609254). The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19631370, PubMed:19609254). {ECO:0000269|PubMed:12391170, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:30584594}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; termination of RNA polymerase III transcription [GO:0006386]; transcription by RNA polymerase III [GO:0006383]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]	DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; termination of RNA polymerase III transcription [GO:0006386]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P32529}.
Q9Y2Y4	reviewed	ZBT32_HUMAN	Zinc finger and BTB domain-containing protein 32 (FANCC-interacting protein) (Fanconi anemia zinc finger protein) (Testis zinc finger protein) (Zinc finger protein 538)	ZBTB32 FAZF TZFP ZNF538	Homo sapiens (Human)	487	FUNCTION: DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity). {ECO:0000250, ECO:0000269|PubMed:10572087}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10572087}. Note=Located in nuclear speckles.
Q9Y2Y6	reviewed	TMM98_HUMAN	Transmembrane protein 98 (Protein TADA1)	TMEM98 UNQ536/PRO1079	Homo sapiens (Human)	226	FUNCTION: Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). {ECO:0000250|UniProtKB:Q91X86}.		negative regulation of myelination [GO:0031642]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein processing [GO:0010955]; T-helper 1 cell differentiation [GO:0045063]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; negative regulation of myelination [GO:0031642]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein processing [GO:0010955]; T-helper 1 cell differentiation [GO:0045063]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25946230}; Single-pass type II membrane protein {ECO:0000269|PubMed:25946230}. Secreted {ECO:0000269|PubMed:25946230}. Secreted, extracellular exosome {ECO:0000269|PubMed:25946230}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91X86}; Single-pass type II membrane protein {ECO:0000269|PubMed:25946230}. Note=Secreted by exosomes through a non-classical pathway. {ECO:0000269|PubMed:25946230}.
Q9Y2Y8	reviewed	PRG3_HUMAN	Proteoglycan 3 (Eosinophil major basic protein homolog) (Prepro-major basic protein homolog) (Prepro-MBPH)	PRG3 MBPH UNQ486/PRO1002	Homo sapiens (Human)	225	FUNCTION: Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. {ECO:0000269|PubMed:10318872}.		basophil activation [GO:0045575]; histamine biosynthetic process [GO:0001694]; immune response [GO:0006955]; leukotriene biosynthetic process [GO:0019370]; negative regulation of translation [GO:0017148]; neutrophil activation [GO:0042119]; positive regulation of interleukin-8 production [GO:0032757]; superoxide anion generation [GO:0042554]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; basophil activation [GO:0045575]; histamine biosynthetic process [GO:0001694]; immune response [GO:0006955]; leukotriene biosynthetic process [GO:0019370]; negative regulation of translation [GO:0017148]; neutrophil activation [GO:0042119]; positive regulation of interleukin-8 production [GO:0032757]; superoxide anion generation [GO:0042554]	SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000269|PubMed:10318872}. Note=Localized to the eosinophil secondary granule.
Q9Y2Y9	reviewed	KLF13_HUMAN	Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1)	KLF13 BTEB3 NSLP1	Homo sapiens (Human)	288	FUNCTION: Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells. {ECO:0000269|PubMed:11477107}.		negative regulation of cell population proliferation [GO:0008285]; negative regulation of erythrocyte differentiation [GO:0045647]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of erythrocyte differentiation [GO:0045647]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
Q9Y2Z0	reviewed	SGT1_HUMAN	Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog)	SUGT1	Homo sapiens (Human)	365	FUNCTION: May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.		kinetochore assembly [GO:0051382]; regulation of protein stability [GO:0031647]; skeletal muscle satellite cell proliferation [GO:0014841]; spindle organization [GO:0007051]	cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]	lncRNA binding [GO:0106222]; protein-folding chaperone binding [GO:0051087]	cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]; lncRNA binding [GO:0106222]; protein-folding chaperone binding [GO:0051087]; kinetochore assembly [GO:0051382]; regulation of protein stability [GO:0031647]; skeletal muscle satellite cell proliferation [GO:0014841]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21864708}. Nucleus {ECO:0000269|PubMed:21864708}. Note=Translocates to the nucleus upon heat shock, requiring S100A6.
Q9Y2Z2	reviewed	MTO1_HUMAN	Protein MTO1 homolog, mitochondrial	MTO1 CGI-02	Homo sapiens (Human)	717	FUNCTION: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. {ECO:0000269|PubMed:12011058}.		mitochondrial tRNA wobble uridine modification [GO:0070899]; tRNA methylation [GO:0030488]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	flavin adenine dinucleotide binding [GO:0050660]; RNA binding [GO:0003723]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; flavin adenine dinucleotide binding [GO:0050660]; RNA binding [GO:0003723]; mitochondrial tRNA wobble uridine modification [GO:0070899]; tRNA methylation [GO:0030488]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
Q9Y2Z4	reviewed	SYYM_HUMAN	Tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)	YARS2 CGI-04	Homo sapiens (Human)	477	FUNCTION: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). {ECO:0000269|PubMed:15779907, ECO:0000269|PubMed:17997975}.		mitochondrial tyrosyl-tRNA aminoacylation [GO:0070184]; translation [GO:0006412]; tRNA aminoacylation [GO:0043039]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]	ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]; tyrosine binding [GO:0072545]; tyrosine-tRNA ligase activity [GO:0004831]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]; tyrosine binding [GO:0072545]; tyrosine-tRNA ligase activity [GO:0004831]; mitochondrial tyrosyl-tRNA aminoacylation [GO:0070184]; translation [GO:0006412]; tRNA aminoacylation [GO:0043039]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:15779907}.
Q9Y2Z9	reviewed	COQ6_HUMAN	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6)	COQ6 CGI-10	Homo sapiens (Human)	468	FUNCTION: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6 (By similarity). Is able to perform the deamination reaction at C4 of 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) to produce DHHB when expressed in yeast cells lacking COQ9, even if utilization of para-aminobenzoic acid (pABA) involving C4-deamination seems not to occur in bacteria, plants and mammals, where only C5 hydroxylation of HHB has been shown (PubMed:26260787). {ECO:0000255|HAMAP-Rule:MF_03193, ECO:0000269|PubMed:26260787}.		ubiquinone biosynthetic process [GO:0006744]	cell projection [GO:0042995]; extrinsic component of mitochondrial inner membrane [GO:0031314]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ubiquinone biosynthesis complex [GO:0110142]	2-octaprenyl-6-methoxyphenol hydroxylase activity [GO:0008681]; 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity [GO:0106364]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]	cell projection [GO:0042995]; extrinsic component of mitochondrial inner membrane [GO:0031314]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ubiquinone biosynthesis complex [GO:0110142]; 2-octaprenyl-6-methoxyphenol hydroxylase activity [GO:0008681]; 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity [GO:0106364]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03193}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03193}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03193}. Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_03193}. Cell projection {ECO:0000255|HAMAP-Rule:MF_03193}. Note=Localizes to cell processes and Golgi apparatus in podocytes. {ECO:0000255|HAMAP-Rule:MF_03193}.
Q9Y303	reviewed	NAGA_HUMAN	N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase) (EC 3.5.1.25) (Amidohydrolase domain-containing protein 2)	AMDHD2 CGI-14	Homo sapiens (Human)	409	FUNCTION: Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. {ECO:0000269|PubMed:22692205}.		carbohydrate metabolic process [GO:0005975]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	cytosol [GO:0005829]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; N-acetylgalactosamine-6-phosphate deacetylase activity [GO:0047419]; N-acetylglucosamine-6-phosphate deacetylase activity [GO:0008448]	cytosol [GO:0005829]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; N-acetylgalactosamine-6-phosphate deacetylase activity [GO:0047419]; N-acetylglucosamine-6-phosphate deacetylase activity [GO:0008448]; carbohydrate metabolic process [GO:0005975]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	
Q9Y314	reviewed	NOSIP_HUMAN	Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein)	NOSIP CGI-25	Homo sapiens (Human)	301	FUNCTION: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}.		negative regulation of catalytic activity [GO:0043086]; negative regulation of nitric-oxide synthase activity [GO:0051001]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of catalytic activity [GO:0043086]; negative regulation of nitric-oxide synthase activity [GO:0051001]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. Nucleus {ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).
Q9Y315	reviewed	DEOC_HUMAN	Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase)	DERA CGI-26	Homo sapiens (Human)	318	FUNCTION: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation. {ECO:0000269|PubMed:25229427}.		carbohydrate catabolic process [GO:0016052]; deoxyribonucleoside catabolic process [GO:0046121]; deoxyribonucleotide catabolic process [GO:0009264]; deoxyribose phosphate catabolic process [GO:0046386]; pentose-phosphate shunt [GO:0006098]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774]	deoxyribose-phosphate aldolase activity [GO:0004139]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774]; deoxyribose-phosphate aldolase activity [GO:0004139]; carbohydrate catabolic process [GO:0016052]; deoxyribonucleoside catabolic process [GO:0046121]; deoxyribonucleotide catabolic process [GO:0009264]; deoxyribose phosphate catabolic process [GO:0046386]; pentose-phosphate shunt [GO:0006098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25229427}. Cytoplasmic granule {ECO:0000269|PubMed:25229427}. Nucleus {ECO:0000269|PubMed:25229427}. Note=Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation. {ECO:0000269|PubMed:25229427}.
Q9Y316	reviewed	MEMO1_HUMAN	Protein MEMO1 (C21orf19-like protein) (Hepatitis C virus NS5A-transactivated protein 7) (HCV NS5A-transactivated protein 7) (Mediator of ErbB2-driven cell motility 1) (Mediator of cell motility 1) (Memo-1)	MEMO1 C2orf4 MEMO NS5ATP7 CGI-27	Homo sapiens (Human)	297	FUNCTION: May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. {ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}.		regulation of microtubule-based process [GO:0032886]	cytosol [GO:0005829]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleus [GO:0005634]; regulation of microtubule-based process [GO:0032886]	
Q9Y320	reviewed	TMX2_HUMAN	Thioredoxin-related transmembrane protein 2 (Cell proliferation-inducing gene 26 protein) (Thioredoxin domain-containing protein 14)	TMX2 TXNDC14 CGI-31 My009 PIG26 PSEC0045 UNQ237/PRO270	Homo sapiens (Human)	296	FUNCTION: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain. {ECO:0000269|PubMed:31735293}.		brain development [GO:0007420]	endoplasmic reticulum membrane [GO:0005789]; membrane-bounded organelle [GO:0043227]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	disulfide oxidoreductase activity [GO:0015036]; identical protein binding [GO:0042802]	endoplasmic reticulum membrane [GO:0005789]; membrane-bounded organelle [GO:0043227]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; disulfide oxidoreductase activity [GO:0015036]; identical protein binding [GO:0042802]; brain development [GO:0007420]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:31735293}; Single-pass type I membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:31735293}. Note=Localizes to endoplasmic reticulum mitochondria-associated membrane (MAMs) that connect the endoplasmic reticulum and the mitochondria. {ECO:0000269|PubMed:31735293}.
Q9Y324	reviewed	FCF1_HUMAN	rRNA-processing protein FCF1 homolog	FCF1 C14orf111 CGI-35	Homo sapiens (Human)	198	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}.		endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; ribosomal small subunit biogenesis [GO:0042274]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
Q9Y328	reviewed	NSG2_HUMAN	Neuronal vesicle trafficking-associated protein 2 (Neuron-specific protein family member 2) (Protein p19) (Hmp19)	NSG2 CALY3	Homo sapiens (Human)	171			clathrin coat assembly [GO:0048268]; dopamine receptor signaling pathway [GO:0007212]; endosomal transport [GO:0016197]	cytoplasmic vesicle membrane [GO:0030659]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi cis cisterna membrane [GO:1990674]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; multivesicular body membrane [GO:0032585]; trans-Golgi network membrane [GO:0032588]	clathrin light chain binding [GO:0032051]	cytoplasmic vesicle membrane [GO:0030659]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi cis cisterna membrane [GO:1990674]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; multivesicular body membrane [GO:0032585]; trans-Golgi network membrane [GO:0032588]; clathrin light chain binding [GO:0032051]; clathrin coat assembly [GO:0048268]; dopamine receptor signaling pathway [GO:0007212]; endosomal transport [GO:0016197]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q3KR51}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q3KR51}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q3KR51}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q3KR51}. Endosome membrane {ECO:0000250|UniProtKB:Q3KR51}. Early endosome membrane {ECO:0000250|UniProtKB:Q3KR51}. Late endosome membrane {ECO:0000250|UniProtKB:Q3KR51}. Lysosome lumen {ECO:0000250|UniProtKB:Q3KR51}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P47759}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P47759}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:P47759}. Note=Endocytosed from the cell surface, thus entered into early endosomes, trafficks to late endosomes and degradates in lysosomes (By similarity). Mainly Golgi stack, but also found in small vacuolar organelles and multivesicular bodies. Found in both stationary and motile endosomes (By similarity). {ECO:0000250|UniProtKB:P47759, ECO:0000250|UniProtKB:Q3KR51}.
Q9Y333	reviewed	LSM2_HUMAN	U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)	LSM2 C6orf28 G7B	Homo sapiens (Human)	95	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.		mRNA catabolic process [GO:0006402]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal tri-snRNP complex assembly [GO:0000244]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]	RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; U6 snRNA binding [GO:0017070]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; U6 snRNA binding [GO:0017070]; mRNA catabolic process [GO:0006402]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal tri-snRNP complex assembly [GO:0000244]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
Q9Y336	reviewed	SIGL9_HUMAN	Sialic acid-binding Ig-like lectin 9 (Siglec-9) (CDw329) (Protein FOAP-9) (CD antigen CD329)	SIGLEC9 UNQ668/PRO1302	Homo sapiens (Human)	463	FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.		cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]	plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9Y337	reviewed	KLK5_HUMAN	Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme)	KLK5 SCTE UNQ570/PRO1132	Homo sapiens (Human)	293	FUNCTION: May be involved in desquamation.		amelogenesis [GO:0097186]; cornification [GO:0070268]; epidermis development [GO:0008544]; extracellular matrix disassembly [GO:0022617]; positive regulation of antibacterial peptide production [GO:0002803]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; proteolysis [GO:0006508]	cytosol [GO:0005829]; epidermal lamellar body [GO:0097209]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	cytosol [GO:0005829]; epidermal lamellar body [GO:0097209]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; amelogenesis [GO:0097186]; cornification [GO:0070268]; epidermis development [GO:0008544]; extracellular matrix disassembly [GO:0022617]; positive regulation of antibacterial peptide production [GO:0002803]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
Q9Y342	reviewed	PLLP_HUMAN	Plasmolipin (Plasma membrane proteolipid)	PLLP PMLP TM4SF11	Homo sapiens (Human)	182	FUNCTION: Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). {ECO:0000250}.		monoatomic ion transport [GO:0006811]; myelination [GO:0042552]	compact myelin [GO:0043218]; membrane [GO:0016020]	structural constituent of myelin sheath [GO:0019911]	compact myelin [GO:0043218]; membrane [GO:0016020]; structural constituent of myelin sheath [GO:0019911]; monoatomic ion transport [GO:0006811]; myelination [GO:0042552]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9Y345	reviewed	SC6A5_HUMAN	Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5)	SLC6A5 GLYT2 NET1	Homo sapiens (Human)	797	FUNCTION: Sodium- and chloride-dependent glycine transporter (PubMed:9845349, PubMed:10381548, PubMed:10606742, PubMed:31370103, PubMed:16751771). Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:9845349). May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (PubMed:9845349). {ECO:0000269|PubMed:10381548, ECO:0000269|PubMed:10606742, ECO:0000269|PubMed:16751771, ECO:0000269|PubMed:31370103, ECO:0000269|PubMed:9845349}.; FUNCTION: [Isoform 2]: Lacks sodium- and chloride-dependent glycine transporter activity. {ECO:0000269|PubMed:10381548}.; FUNCTION: [Isoform 3]: Lacks sodium- and chloride-dependent glycine transporter activity. {ECO:0000269|PubMed:10381548}.		chemical synaptic transmission [GO:0007268]; glycine import across plasma membrane [GO:1903804]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725]; synaptic transmission, glycinergic [GO:0060012]	dense core granule [GO:0031045]; endosome [GO:0005768]; glycinergic synapse [GO:0098690]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	glycine:sodium symporter activity [GO:0015375]; metal ion binding [GO:0046872]	dense core granule [GO:0031045]; endosome [GO:0005768]; glycinergic synapse [GO:0098690]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; glycine:sodium symporter activity [GO:0015375]; metal ion binding [GO:0046872]; chemical synaptic transmission [GO:0007268]; glycine import across plasma membrane [GO:1903804]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725]; synaptic transmission, glycinergic [GO:0060012]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16751771, ECO:0000269|PubMed:31370103}; Multi-pass membrane protein {ECO:0000255}.
Q9Y365	reviewed	STA10_HUMAN	START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10)	STARD10 SDCCAG28 CGI-52	Homo sapiens (Human)	291	FUNCTION: May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes. {ECO:0000250, ECO:0000269|PubMed:15911624}.		lipid transport [GO:0006869]	cytosol [GO:0005829]; intercellular canaliculus [GO:0046581]; membrane [GO:0016020]; microvillus [GO:0005902]; motile cilium [GO:0031514]	lipid binding [GO:0008289]	cytosol [GO:0005829]; intercellular canaliculus [GO:0046581]; membrane [GO:0016020]; microvillus [GO:0005902]; motile cilium [GO:0031514]; lipid binding [GO:0008289]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:17561512}. Membrane {ECO:0000269|PubMed:17561512}. Note=In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm (By similarity). Mainly cytosolic. {ECO:0000250}.
Q9Y366	reviewed	IFT52_HUMAN	Intraflagellar transport protein 52 homolog (Protein NGD5 homolog)	IFT52 C20orf9 NGD5 CGI-53	Homo sapiens (Human)	437	FUNCTION: Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia (PubMed:27466190). Required for the anterograde transport of IFT88 (PubMed:27466190). {ECO:0000269|PubMed:27466190}.		cilium assembly [GO:0060271]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; keratinocyte proliferation [GO:0043616]; negative regulation of keratinocyte proliferation [GO:0010839]; neural tube formation [GO:0001841]; non-motile cilium assembly [GO:1905515]; regulation of protein processing [GO:0070613]; smoothened signaling pathway [GO:0007224]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; dendrite terminus [GO:0044292]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; photoreceptor connecting cilium [GO:0032391]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; dendrite terminus [GO:0044292]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; photoreceptor connecting cilium [GO:0032391]; cilium assembly [GO:0060271]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; keratinocyte proliferation [GO:0043616]; negative regulation of keratinocyte proliferation [GO:0010839]; neural tube formation [GO:0001841]; non-motile cilium assembly [GO:1905515]; regulation of protein processing [GO:0070613]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q62559}.
Q9Y371	reviewed	SHLB1_HUMAN	Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1)	SH3GLB1 KIAA0491 CGI-61	Homo sapiens (Human)	365	FUNCTION: May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity). {ECO:0000250|UniProtKB:Q9JK48, ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144, ECO:0000269|PubMed:17891140, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21068542}.	MISCELLANEOUS: HeLa cells lacking SH3GLB1 show dissociation of outer and inner mitochondrial membrane as well as abnormal mitochondrial morphology. Cells overexpressing SH3GLB1 lacking an N-terminal amphipathic helix show a similar phenotype.; MISCELLANEOUS: SH3GLB1 binds liposomes and induces formation of tubules from liposomes. SH3GLB1 lacking the N-terminal amphipathic helix fails to induce liposome tubulation.	apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; membrane fission [GO:0090148]; membrane organization [GO:0061024]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; positive regulation of membrane tubulation [GO:1903527]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to vacuolar membrane [GO:1903778]; receptor catabolic process [GO:0032801]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]; regulation of protein stability [GO:0031647]	autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrial outer membrane [GO:0005741]; protein-containing complex [GO:0032991]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]	autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrial outer membrane [GO:0005741]; protein-containing complex [GO:0032991]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]; apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; membrane fission [GO:0090148]; membrane organization [GO:0061024]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; positive regulation of membrane tubulation [GO:1903527]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to vacuolar membrane [GO:1903778]; receptor catabolic process [GO:0032801]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15452144}. Golgi apparatus membrane {ECO:0000269|PubMed:21068542}; Peripheral membrane protein {ECO:0000250}. Mitochondrion outer membrane {ECO:0000269|PubMed:15452144}; Peripheral membrane protein {ECO:0000269|PubMed:15452144}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:17891140}. Midbody {ECO:0000269|PubMed:20643123}. Note=Association with the Golgi apparatus depends on the cell type (By similarity). Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes (PubMed:17891140). {ECO:0000250, ECO:0000269|PubMed:17891140}.
Q9Y375	reviewed	CIA30_HUMAN	Complex I intermediate-associated protein 30, mitochondrial (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1)	NDUFAF1 CIA30 CGI-65	Homo sapiens (Human)	327	FUNCTION: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. {ECO:0000269|PubMed:16218961, ECO:0000269|PubMed:17557076, ECO:0000269|PubMed:32320651}.		chaperone-mediated protein complex assembly [GO:0051131]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; protein-containing complex assembly [GO:0065003]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	unfolded protein binding [GO:0051082]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; unfolded protein binding [GO:0051082]; chaperone-mediated protein complex assembly [GO:0051131]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16218961, ECO:0000269|PubMed:17557076}. Mitochondrion matrix {ECO:0000305|PubMed:17557076}. Note=Peripherally associated with the matrix face of the mitochondrial inner membrane. {ECO:0000305|PubMed:17557076}.
Q9Y376	reviewed	CAB39_HUMAN	Calcium-binding protein 39 (MO25alpha) (Protein Mo25)	CAB39 MO25 CGI-66	Homo sapiens (Human)	341	FUNCTION: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. {ECO:0000269|PubMed:19892943}.		cellular hypotonic response [GO:0071476]; intracellular signal transduction [GO:0035556]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; response to activity [GO:0014823]; response to thyroid hormone [GO:0097066]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; serine/threonine protein kinase complex [GO:1902554]; Z disc [GO:0030018]	kinase binding [GO:0019900]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activator activity [GO:0043539]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; serine/threonine protein kinase complex [GO:1902554]; Z disc [GO:0030018]; kinase binding [GO:0019900]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activator activity [GO:0043539]; cellular hypotonic response [GO:0071476]; intracellular signal transduction [GO:0035556]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; response to activity [GO:0014823]; response to thyroid hormone [GO:0097066]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q9Y383	reviewed	LC7L2_HUMAN	Putative RNA-binding protein Luc7-like 2	LUC7L2 CGI-59 CGI-74	Homo sapiens (Human)	392	FUNCTION: May bind to RNA via its Arg/Ser-rich domain.		mRNA splice site recognition [GO:0006376]	nuclear speck [GO:0016607]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]	enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]; enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA splice site recognition [GO:0006376]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q7TNC4}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TNC4}. Note=Colocalizes with SCNM1 and SNRNP70 in nuclear speckles. {ECO:0000250|UniProtKB:Q7TNC4}.
Q9Y385	reviewed	UB2J1_HUMAN	Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e)	UBE2J1 NCUBE1 CGI-76 HSPC153 HSPC205	Homo sapiens (Human)	318	FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress (PubMed:28321712). Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis (PubMed:24020373). Acts also as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26 (PubMed:33472082). {ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000269|PubMed:12082160, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:24020373, ECO:0000269|PubMed:28321712, ECO:0000269|PubMed:33472082}.; FUNCTION: (Microbial infection) Promotes Dengue virus RNA replication by negatively regulating IFN-beta signaling and mediating 'Lys-48'-linked ubiquitination on IRF3 (PubMed:30157886). {ECO:0000269|PubMed:30157886}.		negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein N-linked glycosylation via asparagine [GO:0018279]; protein ubiquitination [GO:0016567]; regulation of macrophage cytokine production [GO:0010935]; regulation of tumor necrosis factor production [GO:0032680]; spermatid development [GO:0007286]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]	endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein N-linked glycosylation via asparagine [GO:0018279]; protein ubiquitination [GO:0016567]; regulation of macrophage cytokine production [GO:0010935]; regulation of tumor necrosis factor production [GO:0032680]; spermatid development [GO:0007286]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12082160, ECO:0000269|PubMed:24020373, ECO:0000269|PubMed:33472082}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12082160}.
Q9Y388	reviewed	RBMX2_HUMAN	RNA-binding motif protein, X-linked 2	RBMX2 CGI-79	Homo sapiens (Human)	322	FUNCTION: Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.		mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	endoplasmic reticulum [GO:0005783]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]	RNA binding [GO:0003723]	endoplasmic reticulum [GO:0005783]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316}.
Q9Y394	reviewed	DHRS7_HUMAN	Dehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1)	DHRS7 DHRS7A RETSDR4 SDR34C1 CGI-86 UNQ285/PRO3448	Homo sapiens (Human)	339	FUNCTION: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics (PubMed:24246760, PubMed:26466768, PubMed:28687384, PubMed:28457967). Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function (PubMed:28687384, PubMed:28457967). Involved in the reduction of all-trans-retinal to all-trans-retinol (PubMed:26466768). Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable (PubMed:28457967). Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group (PubMed:24246760, PubMed:26466768). A dehydrogenase activity has not been detected so far (PubMed:24246760). May play a role as tumor suppressor (PubMed:26311046). {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:26311046, ECO:0000269|PubMed:26466768, ECO:0000269|PubMed:28457967, ECO:0000269|PubMed:28687384}.			endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	carbonyl reductase (NADPH) activity [GO:0004090]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; carbonyl reductase (NADPH) activity [GO:0004090]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:28457967}. Note=Bound to the endoplasmic reticulum membrane, possibly through a N-terminus anchor. The main bulk of the polypeptide chain was first reported to be facing toward the lumen of the endoplasmic reticulum (PubMed:24246760). However, it was later shown to be facing the cytosol (PubMed:28457967). {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:28457967}.
Q9Y397	reviewed	ZDHC9_HUMAN	Palmitoyltransferase ZDHHC9 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 9) (DHHC-9) (DHHC9) (Zinc finger protein 379) (Zinc finger protein 380)	ZDHHC9 CXorf11 ZDHHC10 ZNF379 ZNF380 CGI-89 UNQ261/PRO298	Homo sapiens (Human)	364	FUNCTION: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (Probable). The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (PubMed:16000296). May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269|PubMed:16000296, ECO:0000269|PubMed:27481942}.; FUNCTION: (Microbial infection) Through a sequential action with ZDHHC20, rapidly and efficiently palmitoylates SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}.		MAPK cascade [GO:0000165]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation by host of viral process [GO:0044794]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; palmitoyltransferase complex [GO:0002178]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; Ras palmitoyltransferase activity [GO:0043849]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; palmitoyltransferase complex [GO:0002178]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; Ras palmitoyltransferase activity [GO:0043849]; MAPK cascade [GO:0000165]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation by host of viral process [GO:0044794]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16000296, ECO:0000269|PubMed:34599882}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:16000296, ECO:0000269|PubMed:27481942}; Multi-pass membrane protein {ECO:0000255}.
Q9Y399	reviewed	RT02_HUMAN	Small ribosomal subunit protein uS2m (28S ribosomal protein S2, mitochondrial) (MRP-S2) (S2mt)	MRPS2 CGI-91	Homo sapiens (Human)	296	FUNCTION: Required for mitoribosome formation and stability, and mitochondrial translation. {ECO:0000269|PubMed:29576219}.		mitochondrial ribosome assembly [GO:0061668]; mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial ribosome assembly [GO:0061668]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
Q9Y3A0	reviewed	COQ4_HUMAN	Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (Coenzyme Q biosynthesis protein 4 homolog)	COQ4 CGI-92	Homo sapiens (Human)	265	FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111, ECO:0000269|PubMed:18474229}.		ubiquinone biosynthetic process [GO:0006744]	extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; ubiquinone biosynthesis complex [GO:0110142]		extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; ubiquinone biosynthesis complex [GO:0110142]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Q9Y3A2	reviewed	UTP11_HUMAN	Probable U3 small nucleolar RNA-associated protein 11 (U3 snoRNA-associated protein 11) (UTP11-like protein)	UTP11 UTP11L CGI-94 HDCMB12P	Homo sapiens (Human)	253	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}.		nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
Q9Y3A3	reviewed	PHOCN_HUMAN	MOB-like protein phocein (2C4D) (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3)	MOB4 MOB3 MOBKL3 PHOCN PREI3 CGI-95	Homo sapiens (Human)	225	FUNCTION: May play a role in membrane trafficking, specifically in membrane budding reactions. {ECO:0000250}.			cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]	kinase binding [GO:0019900]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11319234}. Membrane {ECO:0000269|PubMed:11319234}; Peripheral membrane protein {ECO:0000269|PubMed:11319234}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:11319234}; Peripheral membrane protein {ECO:0000269|PubMed:11319234}. Note=In a perinuclear punctate pattern. Associated with membranes and the Golgi stacks.
Q9Y3A4	reviewed	RRP7A_HUMAN	Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14)	RRP7A CGI-96	Homo sapiens (Human)	280	FUNCTION: Nucleolar protein that is involved in ribosomal RNA (rRNA) processing (PubMed:33199730). Also plays a role in primary cilia resorption, and cell cycle progression in neurogenesis and neocortex development (PubMed:33199730). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:33199730, ECO:0000269|PubMed:34516797}.		blastocyst formation [GO:0001825]; cilium disassembly [GO:0061523]; protein localization to nucleolus [GO:1902570]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]	centrosome [GO:0005813]; cilium [GO:0005929]; CURI complex [GO:0032545]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; UTP-C complex [GO:0034456]	RNA binding [GO:0003723]	centrosome [GO:0005813]; cilium [GO:0005929]; CURI complex [GO:0032545]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; UTP-C complex [GO:0034456]; RNA binding [GO:0003723]; blastocyst formation [GO:0001825]; cilium disassembly [GO:0061523]; protein localization to nucleolus [GO:1902570]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:33199730, ECO:0000269|PubMed:34516797}. Cell projection, cilium {ECO:0000269|PubMed:33199730}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:33199730}.
Q9Y3A5	reviewed	SBDS_HUMAN	Ribosome maturation protein SBDS (Shwachman-Bodian-Diamond syndrome protein)	SBDS CGI-97	Homo sapiens (Human)	250	FUNCTION: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. {ECO:0000269|PubMed:17643419, ECO:0000269|PubMed:19602484, ECO:0000269|PubMed:19759903, ECO:0000269|PubMed:21536732}.		bone marrow development [GO:0048539]; bone mineralization [GO:0030282]; cytosolic ribosome assembly [GO:0042256]; hematopoietic progenitor cell differentiation [GO:0002244]; inner cell mass cell proliferation [GO:0001833]; leukocyte chemotaxis [GO:0030595]; mitotic spindle organization [GO:0007052]; rRNA processing [GO:0006364]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	microtubule binding [GO:0008017]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; microtubule binding [GO:0008017]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; bone marrow development [GO:0048539]; bone mineralization [GO:0030282]; cytosolic ribosome assembly [GO:0042256]; hematopoietic progenitor cell differentiation [GO:0002244]; inner cell mass cell proliferation [GO:0001833]; leukocyte chemotaxis [GO:0030595]; mitotic spindle organization [GO:0007052]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484, PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903). {ECO:0000269|PubMed:19759903}.
Q9Y3A6	reviewed	TMED5_HUMAN	Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2) (p28)	TMED5 CGI-100 UNQ397/PRO733	Homo sapiens (Human)	229	FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport. {ECO:0000269|PubMed:19948005}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi ribbon formation [GO:0090161]; intracellular protein transport [GO:0006886]	cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]		cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi ribbon formation [GO:0090161]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19948005}; Single-pass type I membrane protein {ECO:0000269|PubMed:19948005}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:19948005}; Single-pass type I membrane protein {ECO:0000269|PubMed:19948005}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:19948005}; Single-pass type I membrane protein {ECO:0000269|PubMed:19948005}. Note=Probably cycles between compartments of the early secretatory pathway.
Q9Y3B2	reviewed	EXOS1_HUMAN	Exosome complex component CSL4 (Exosome component 1)	EXOSC1 CSL4 CGI-108	Homo sapiens (Human)	195	FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.		RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}.
Q9Y3B3	reviewed	TMED7_HUMAN	Transmembrane emp24 domain-containing protein 7 (p24 family protein gamma-3) (p24gamma3) (p27)	TMED7 CGI-109	Homo sapiens (Human)	224	FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]	COPI vesicle coat [GO:0030126]; COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]		COPI vesicle coat [GO:0030126]; COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway.
Q9Y3B4	reviewed	SF3B6_HUMAN	Splicing factor 3B subunit 6 (Pre-mRNA branch site protein p14) (SF3b 14 kDa subunit) (SF3B14a) (Spliceosome-associated protein, 14-kDa) (Splicing factor 3b, subunit 6, 14kDa)	SF3B6 SAP14 SF3B14 SF3B14A CGI-110 HSPC175 HT006	Homo sapiens (Human)	125	FUNCTION: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (PubMed:12234937). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (PubMed:16432215). Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (PubMed:16432215). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16432215, ECO:0000269|PubMed:27720643}.		blastocyst formation [GO:0001825]; mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type spliceosomal complex [GO:0005684]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type spliceosomal complex [GO:0005684]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; blastocyst formation [GO:0001825]; mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300}.
Q9Y3B7	reviewed	RM11_HUMAN	Large ribosomal subunit protein uL11m (39S ribosomal protein L11, mitochondrial) (L11mt) (MRP-L11)	MRPL11 CGI-113	Homo sapiens (Human)	192			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279069, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9Y3B8	reviewed	ORN_HUMAN	Oligoribonuclease, mitochondrial (EC 3.1.15.-) (RNA exonuclease 2 homolog) (Small fragment nuclease)	REXO2 SFN SMFN CGI-114	Homo sapiens (Human)	237	FUNCTION: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:31588022, PubMed:30926754, PubMed:32365187, PubMed:23741365). Binds and degrades longer oligonucleotides with a lower affinity (PubMed:31588022, PubMed:30926754, PubMed:32365187). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (PubMed:31588022, PubMed:30926754, PubMed:32365187). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:Q9D8S4, ECO:0000269|PubMed:23741365, ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:31588022, ECO:0000269|PubMed:32365187}.; FUNCTION: [Isoform 3]: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. {ECO:0000269|PubMed:10851236, ECO:0000269|PubMed:16682444}.		nucleobase-containing compound metabolic process [GO:0006139]; nucleotide metabolic process [GO:0009117]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]	3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; 3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; 3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; 3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; nucleobase-containing compound metabolic process [GO:0006139]; nucleotide metabolic process [GO:0009117]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:23741365}. Mitochondrion matrix {ECO:0000269|PubMed:23741365}. Mitochondrion {ECO:0000269|PubMed:32365187}. Cytoplasm {ECO:0000269|PubMed:23741365, ECO:0000269|PubMed:32365187}. Nucleus {ECO:0000269|PubMed:32365187}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:32365187}. Nucleus {ECO:0000269|PubMed:32365187}.
Q9Y3C0	reviewed	WASC3_HUMAN	WASH complex subunit 3 (Coiled-coil domain-containing protein 53)	WASHC3 AD-016 CCDC53 CGI-116 x0009	Homo sapiens (Human)	194	FUNCTION: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093}.		actin filament polymerization [GO:0030041]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]	early endosome membrane [GO:0031901]; WASH complex [GO:0071203]		early endosome membrane [GO:0031901]; WASH complex [GO:0071203]; actin filament polymerization [GO:0030041]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]	SUBCELLULAR LOCATION: Early endosome {ECO:0000305}.
Q9Y3C4	reviewed	TPRKB_HUMAN	EKC/KEOPS complex subunit TPRKB (PRPK-binding protein) (TP53RK-binding protein)	TPRKB CGI-121 My019	Homo sapiens (Human)	175	FUNCTION: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828). TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828). {ECO:0000269|PubMed:28805828, ECO:0000305|PubMed:22912744}.		tRNA threonylcarbamoyladenosine modification [GO:0002949]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleus [GO:0005634]	protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; tRNA threonylcarbamoyladenosine modification [GO:0002949]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12659830, ECO:0000269|PubMed:28805828}. Nucleus {ECO:0000269|PubMed:12659830, ECO:0000269|PubMed:22912744, ECO:0000269|PubMed:28805828}.
Q9Y3C5	reviewed	RNF11_HUMAN	RING finger protein 11	RNF11 CGI-123	Homo sapiens (Human)	154	FUNCTION: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. {ECO:0000269|PubMed:14755250}.		protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511]	early endosome [GO:0005769]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; recycling endosome [GO:0055037]; ubiquitin ligase complex [GO:0000151]	DNA binding [GO:0003677]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	early endosome [GO:0005769]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; recycling endosome [GO:0055037]; ubiquitin ligase complex [GO:0000151]; DNA binding [GO:0003677]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1. {ECO:0000269|PubMed:16123141}.
Q9Y3C6	reviewed	PPIL1_HUMAN	Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase PPIL1)	PPIL1 CYPL1 CGI-124 UNQ2425/PRO4984	Homo sapiens (Human)	166	FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346, PubMed:33220177). PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688). Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 (PubMed:33220177). Plays an important role in embryonic brain development; this function is independent of its isomerase activity (PubMed:33220177). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16595688, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:33220177}.		embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]	cyclosporin A binding [GO:0016018]; disordered domain specific binding [GO:0097718]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]; cyclosporin A binding [GO:0016018]; disordered domain specific binding [GO:0097718]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
Q9Y3C7	reviewed	MED31_HUMAN	Mediator of RNA polymerase II transcription subunit 31 (Mediator complex subunit 31) (Mediator complex subunit SOH1) (hSOH1)	MED31 SOH1 CGI-125	Homo sapiens (Human)	131	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.		limb development [GO:0060173]; negative regulation of fibroblast proliferation [GO:0048147]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630]; limb development [GO:0060173]; negative regulation of fibroblast proliferation [GO:0048147]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y3C8	reviewed	UFC1_HUMAN	Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1)	UFC1 CGI-126 HSPC155	Homo sapiens (Human)	167	FUNCTION: E1-like enzyme which specifically catalyzes the second step in ufmylation (PubMed:15071506, PubMed:29868776). Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage (PubMed:15071506, PubMed:29868776). Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:32160526). {ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:29868776, ECO:0000269|PubMed:32160526}.		brain development [GO:0007420]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]	extracellular exosome [GO:0070062]	UFM1 conjugating enzyme activity [GO:0061657]; UFM1 transferase activity [GO:0071568]	extracellular exosome [GO:0070062]; UFM1 conjugating enzyme activity [GO:0061657]; UFM1 transferase activity [GO:0071568]; brain development [GO:0007420]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]	
Q9Y3D0	reviewed	CIA2B_HUMAN	Cytosolic iron-sulfur assembly component 2B (MSS19-interacting protein of 18 kDa) (Mitotic spindle-associated MMXD complex subunit MIP18) (Protein FAM96B)	CIAO2B CIAB FAM96B MIP18 CGI-128 HSPC118	Homo sapiens (Human)	163	FUNCTION: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004, PubMed:22678362, PubMed:22678361, PubMed:29848660). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004, PubMed:29848660). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660). {ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:22678361, ECO:0000269|PubMed:22678362, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:29848660}.		chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]; protein maturation by iron-sulfur cluster transfer [GO:0097428]	CIA complex [GO:0097361]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]		CIA complex [GO:0097361]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]; protein maturation by iron-sulfur cluster transfer [GO:0097428]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20797633}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:29848660}. Midbody {ECO:0000269|PubMed:29848660}. Note=In mitosis, localizes to the spindle during metaphase and the spindle midbody during telophase (PubMed:29848660). Co-localizes with KIF4A to the spindle midzone and midbody during telophase and cytokinesis (PubMed:29848660). {ECO:0000269|PubMed:29848660}.
Q9Y3D2	reviewed	MSRB2_HUMAN	Methionine-R-sulfoxide reductase B2, mitochondrial (MsrB2) (EC 1.8.4.12) (EC 1.8.4.14)	MSRB2 CBS-1 MSRB CGI-131	Homo sapiens (Human)	182	FUNCTION: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. {ECO:0000269|PubMed:18424444}.		actin filament polymerization [GO:0030041]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	actin binding [GO:0003779]; L-methionine-(R)-S-oxide reductase activity [GO:0033745]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; actin binding [GO:0003779]; L-methionine-(R)-S-oxide reductase activity [GO:0033745]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; zinc ion binding [GO:0008270]; actin filament polymerization [GO:0030041]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18424444}.
Q9Y3D3	reviewed	RT16_HUMAN	Small ribosomal subunit protein bS16m (28S ribosomal protein S16, mitochondrial) (MRP-S16) (S16mt)	MRPS16 RPMS16 CGI-132	Homo sapiens (Human)	137			mitochondrial translation [GO:0032543]; translation [GO:0006412]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
Q9Y3D6	reviewed	FIS1_HUMAN	Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11)	FIS1 TTC11 CGI-135	Homo sapiens (Human)	152	FUNCTION: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:12783892, PubMed:12861026, PubMed:14996942, PubMed:23283981). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (PubMed:12861026, PubMed:16118244, PubMed:23283981, PubMed:23530241, PubMed:24196833). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (PubMed:23530241, PubMed:24196833). Also mediates peroxisomal fission (PubMed:16107562). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (PubMed:24196833). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (PubMed:12783892). {ECO:0000269|PubMed:12783892, ECO:0000269|PubMed:12861026, ECO:0000269|PubMed:14996942, ECO:0000269|PubMed:16107562, ECO:0000269|PubMed:16118244, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}.		autophagy of mitochondrion [GO:0000422]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; mitochondrion morphogenesis [GO:0070584]; negative regulation of ATP metabolic process [GO:1903579]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of fatty acid transport [GO:2000192]; peroxisome fission [GO:0016559]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]; protein targeting to mitochondrion [GO:0006626]; regulation of mitochondrion organization [GO:0010821]; release of cytochrome c from mitochondria [GO:0001836]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; lipid binding [GO:0008289]; molecular adaptor activity [GO:0060090]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; molecular adaptor activity [GO:0060090]; autophagy of mitochondrion [GO:0000422]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; mitochondrion morphogenesis [GO:0070584]; negative regulation of ATP metabolic process [GO:1903579]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of fatty acid transport [GO:2000192]; peroxisome fission [GO:0016559]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]; protein targeting to mitochondrion [GO:0006626]; regulation of mitochondrion organization [GO:0010821]; release of cytochrome c from mitochondria [GO:0001836]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:12783892, ECO:0000269|PubMed:14623186, ECO:0000269|PubMed:14996942, ECO:0000269|PubMed:16107562}; Single-pass membrane protein {ECO:0000269|PubMed:14996942}. Peroxisome membrane {ECO:0000269|PubMed:16107562}; Single-pass membrane protein {ECO:0000305|PubMed:16107562}.
Q9Y3D7	reviewed	TIM16_HUMAN	Mitochondrial import inner membrane translocase subunit TIM16 (Mitochondria-associated granulocyte macrophage CSF-signaling molecule) (Presequence translocated-associated motor subunit PAM16)	PAM16 MAGMAS TIM16 TIMM16 CGI-136	Homo sapiens (Human)	125	FUNCTION: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. {ECO:0000269|PubMed:20053669}.		intracellular protein transport [GO:0006886]; negative regulation of ATP-dependent activity [GO:0032780]; ossification [GO:0001503]; protein import into mitochondrial matrix [GO:0030150]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; PAM complex, Tim23 associated import motor [GO:0001405]; protein-containing complex [GO:0032991]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]		mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; PAM complex, Tim23 associated import motor [GO:0001405]; protein-containing complex [GO:0032991]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; intracellular protein transport [GO:0006886]; negative regulation of ATP-dependent activity [GO:0032780]; ossification [GO:0001503]; protein import into mitochondrial matrix [GO:0030150]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11750097, ECO:0000269|PubMed:20053669}; Peripheral membrane protein {ECO:0000269|PubMed:11750097, ECO:0000269|PubMed:20053669}; Matrix side {ECO:0000269|PubMed:11750097, ECO:0000269|PubMed:20053669}.
Q9Y3D8	reviewed	KAD6_HUMAN	Adenylate kinase isoenzyme 6 (AK6) (EC 2.7.4.3) (Adrenal gland protein AD-004) (Coilin-interacting nuclear ATPase protein) (hCINAP) (Dual activity adenylate kinase/ATPase) (AK/ATPase)	AK6 CINAP AD-004 CGI-137	Homo sapiens (Human)	172	FUNCTION: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation. {ECO:0000269|PubMed:15630091}.		nucleobase-containing small molecule interconversion [GO:0015949]; phosphorylation [GO:0016310]	Cajal body [GO:0015030]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleoside monophosphate kinase activity [GO:0050145]	Cajal body [GO:0015030]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleoside monophosphate kinase activity [GO:0050145]; nucleobase-containing small molecule interconversion [GO:0015949]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Nucleus, Cajal body. Note=Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.
Q9Y3D9	reviewed	RT23_HUMAN	Small ribosomal subunit protein mS23 (28S ribosomal protein S23, mitochondrial) (MRP-S23) (S23mt)	MRPS23 CGI-138 HSPC329	Homo sapiens (Human)	190			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
Q9Y3E0	reviewed	GOT1B_HUMAN	Vesicle transport protein GOT1B (Germ cell tumor 2) (Golgi transport 1 homolog B) (Putative NF-kappa-B-activating protein 470) (hGOT1a)	GOLT1B GCT2 GOT1A CGI-141 HDCMA39P UNQ432/PRO793	Homo sapiens (Human)	138	FUNCTION: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; protein-containing complex [GO:0032991]		cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:10406798}; Multi-pass membrane protein {ECO:0000269|PubMed:10406798}.
Q9Y3E1	reviewed	HDGR3_HUMAN	Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma-derived growth factor 2) (HDGF-2)	HDGFL3 HDGF2 HDGFRP3 CGI-142	Homo sapiens (Human)	203	FUNCTION: Enhances DNA synthesis and may play a role in cell proliferation. {ECO:0000269|PubMed:10581169}.		chromatin remodeling [GO:0006338]; microtubule polymerization [GO:0046785]; negative regulation of microtubule depolymerization [GO:0007026]; neuron projection development [GO:0031175]	cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	growth factor activity [GO:0008083]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631]	cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; growth factor activity [GO:0008083]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631]; chromatin remodeling [GO:0006338]; microtubule polymerization [GO:0046785]; negative regulation of microtubule depolymerization [GO:0007026]; neuron projection development [GO:0031175]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10581169}.
Q9Y3E2	reviewed	BOLA1_HUMAN	BolA-like protein 1 (hBolA)	BOLA1 CGI-143	Homo sapiens (Human)	137	FUNCTION: Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772). May protect cells against oxidative stress (PubMed:22746225). {ECO:0000250|UniProtKB:Q3E793, ECO:0000269|PubMed:22746225, ECO:0000305|PubMed:27532772}.		cell redox homeostasis [GO:0045454]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]	iron-sulfur cluster assembly complex [GO:1990229]; mitochondrion [GO:0005739]		iron-sulfur cluster assembly complex [GO:1990229]; mitochondrion [GO:0005739]; cell redox homeostasis [GO:0045454]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22746225}.
Q9Y3E5	reviewed	PTH2_HUMAN	Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription 1)	PTRH2 BIT1 PTH2 CGI-147	Homo sapiens (Human)	179	FUNCTION: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. {ECO:0000250}.; FUNCTION: Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1. {ECO:0000269|PubMed:15006356}.		apoptotic process [GO:0006915]; negative regulation of anoikis [GO:2000811]; negative regulation of gene expression [GO:0010629]; positive regulation of anoikis [GO:2000210]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	aminoacyl-tRNA hydrolase activity [GO:0004045]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; aminoacyl-tRNA hydrolase activity [GO:0004045]; apoptotic process [GO:0006915]; negative regulation of anoikis [GO:2000811]; negative regulation of gene expression [GO:0010629]; positive regulation of anoikis [GO:2000210]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:27184847}; Single-pass membrane protein {ECO:0000255}.
Q9Y3E7	reviewed	CHMP3_HUMAN	Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Neuroendocrine differentiation factor) (Vacuolar protein sorting-associated protein 24) (hVps24)	CHMP3 CGI149 NEDF VPS24 CGI-149	Homo sapiens (Human)	222	FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells. {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:15707591, ECO:0000269|PubMed:16740483, ECO:0000269|PubMed:17331679, ECO:0000269|PubMed:18076377}.	MISCELLANEOUS: Its overexpression strongly inhibits HIV-1 release.	apoptotic process [GO:0006915]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; endosome transport via multivesicular body sorting pathway [GO:0032509]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of cytokinesis [GO:0032467]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of endosome size [GO:0051036]; regulation of mitotic spindle assembly [GO:1901673]; suppression of viral release by host [GO:0044790]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; phosphatidylcholine binding [GO:0031210]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; ubiquitin-specific protease binding [GO:1990381]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; phosphatidylcholine binding [GO:0031210]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; ubiquitin-specific protease binding [GO:1990381]; apoptotic process [GO:0006915]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; endosome transport via multivesicular body sorting pathway [GO:0032509]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of cytokinesis [GO:0032467]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of endosome size [GO:0051036]; regulation of mitotic spindle assembly [GO:1901673]; suppression of viral release by host [GO:0044790]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane {ECO:0000305}. Note=Localizes to the midbody of dividing cells.
Q9Y3F4	reviewed	STRAP_HUMAN	Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD)	STRAP MAWD UNRIP	Homo sapiens (Human)	350	FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}.		alternative mRNA splicing, via spliceosome [GO:0000380]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron differentiation [GO:0030182]; spliceosomal snRNP assembly [GO:0000387]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; U2 snRNP binding [GO:1990447]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; U2 snRNP binding [GO:1990447]; alternative mRNA splicing, via spliceosome [GO:0000380]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron differentiation [GO:0030182]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.
Q9Y3I0	reviewed	RTCB_HUMAN	RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)	RTCB C22orf28 HSPC117	Homo sapiens (Human)	505	FUNCTION: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. {ECO:0000255|HAMAP-Rule:MF_03144, ECO:0000269|PubMed:21311021, ECO:0000269|PubMed:24870230}.	MISCELLANEOUS: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. {ECO:0000255|HAMAP-Rule:MF_03144, ECO:0000305|PubMed:24870230}.	in utero embryonic development [GO:0001701]; placenta development [GO:0001890]; tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate [GO:0000971]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669]	GTP binding [GO:0005525]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA ligase (ATP) activity [GO:0003972]; vinculin binding [GO:0017166]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA ligase (ATP) activity [GO:0003972]; vinculin binding [GO:0017166]; in utero embryonic development [GO:0001701]; placenta development [GO:0001890]; tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate [GO:0000971]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24608264}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03144, ECO:0000269|PubMed:24608264}. Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low. {ECO:0000269|PubMed:24608264}.
Q9Y3I1	reviewed	FBX7_HUMAN	F-box only protein 7	FBXO7 FBX7	Homo sapiens (Human)	522	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability (PubMed:15145941, PubMed:34791250). Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5 (PubMed:15145941, PubMed:16510124, PubMed:22212761). Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway (PubMed:33010352). Inhibits NF-kappa-B pathway also by promoting the ubiquitination of TRAF2 (PubMed:22212761). Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains (By similarity). Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death (PubMed:36646384). {ECO:0000250|UniProtKB:Q3U7U3, ECO:0000269|PubMed:15145941, ECO:0000269|PubMed:16510124, ECO:0000269|PubMed:22212761, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:33010352, ECO:0000269|PubMed:34791250, ECO:0000269|PubMed:36646384}.		autophagy of mitochondrion [GO:0000422]; lymphocyte differentiation [GO:0030098]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of lymphocyte differentiation [GO:0045620]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; positive regulation of autophagy of mitochondrion [GO:1903599]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein targeting to mitochondrion [GO:0006626]; protein ubiquitination [GO:0016567]; regulation of locomotion [GO:0040012]; regulation of neuron projection development [GO:0010975]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511]	classical Lewy body [GO:0097414]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cytoplasmic inclusion [GO:0097409]; Lewy body core [GO:1990037]; Lewy body corona [GO:1990038]; Lewy neurite [GO:0097462]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]	protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	classical Lewy body [GO:0097414]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cytoplasmic inclusion [GO:0097409]; Lewy body core [GO:1990037]; Lewy body corona [GO:1990038]; Lewy neurite [GO:0097462]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; autophagy of mitochondrion [GO:0000422]; lymphocyte differentiation [GO:0030098]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of lymphocyte differentiation [GO:0045620]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; positive regulation of autophagy of mitochondrion [GO:1903599]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein targeting to mitochondrion [GO:0006626]; protein ubiquitination [GO:0016567]; regulation of locomotion [GO:0040012]; regulation of neuron projection development [GO:0010975]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16096642, ECO:0000269|PubMed:18495667}. Nucleus {ECO:0000269|PubMed:16096642, ECO:0000269|PubMed:18495667, ECO:0000269|PubMed:33010352}. Mitochondrion {ECO:0000269|PubMed:23933751}. Cytoplasm, cytosol {ECO:0000269|PubMed:23933751}. Note=Predominantly cytoplasmic (PubMed:16096642). A minor proportion is detected in the nucleus (PubMed:16096642). Relocates from the cytosol to depolarized mitochondria (PubMed:23933751). {ECO:0000269|PubMed:16096642, ECO:0000269|PubMed:23933751}.
Q9Y3L3	reviewed	3BP1_HUMAN	SH3 domain-binding protein 1	SH3BP1	Homo sapiens (Human)	701	FUNCTION: GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}.		actin filament organization [GO:0007015]; cell junction assembly [GO:0034329]; cell migration [GO:0016477]; establishment of epithelial cell apical/basal polarity [GO:0045198]; filopodium assembly [GO:0046847]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; positive regulation of GTPase activity [GO:0043547]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament depolymerization [GO:0030834]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of Rac protein signal transduction [GO:0035020]; regulation of small GTPase mediated signal transduction [GO:0051056]; ruffle assembly [GO:0097178]; semaphorin-plexin signaling pathway [GO:0071526]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; phagocytic cup [GO:0001891]	GTPase activator activity [GO:0005096]; semaphorin receptor binding [GO:0030215]; SH3 domain binding [GO:0017124]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; phagocytic cup [GO:0001891]; GTPase activator activity [GO:0005096]; semaphorin receptor binding [GO:0030215]; SH3 domain binding [GO:0017124]; actin filament organization [GO:0007015]; cell junction assembly [GO:0034329]; cell migration [GO:0016477]; establishment of epithelial cell apical/basal polarity [GO:0045198]; filopodium assembly [GO:0046847]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; positive regulation of GTPase activity [GO:0043547]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament depolymerization [GO:0030834]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of Rac protein signal transduction [GO:0035020]; regulation of small GTPase mediated signal transduction [GO:0051056]; ruffle assembly [GO:0097178]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Cell projection {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:24841563}. Cell junction, tight junction {ECO:0000269|PubMed:22891260}. Cell junction, adherens junction {ECO:0000269|PubMed:22891260}. Cell projection, phagocytic cup {ECO:0000269|PubMed:26465210}. Nucleus {ECO:0000269|PubMed:22891260}. Cytoplasm, cytosol {ECO:0000269|PubMed:22891260}. Note=Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563). Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}.
Q9Y3L5	reviewed	RAP2C_HUMAN	Ras-related protein Rap-2c (EC 3.6.5.2)	RAP2C	Homo sapiens (Human)	183	FUNCTION: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. {ECO:0000269|PubMed:17447155}.		establishment of endothelial intestinal barrier [GO:0090557]; negative regulation of cell migration [GO:0030336]; positive regulation of protein autophosphorylation [GO:0031954]; Rap protein signal transduction [GO:0032486]; regulation of protein tyrosine kinase activity [GO:0061097]	bicellular tight junction [GO:0005923]; cell-cell contact zone [GO:0044291]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; tertiary granule membrane [GO:0070821]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; transcription coactivator activity [GO:0003713]	bicellular tight junction [GO:0005923]; cell-cell contact zone [GO:0044291]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; tertiary granule membrane [GO:0070821]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; transcription coactivator activity [GO:0003713]; establishment of endothelial intestinal barrier [GO:0090557]; negative regulation of cell migration [GO:0030336]; positive regulation of protein autophosphorylation [GO:0031954]; Rap protein signal transduction [GO:0032486]; regulation of protein tyrosine kinase activity [GO:0061097]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17447155}. Recycling endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Q9Y3M2	reviewed	CBY1_HUMAN	Protein chibby homolog 1 (ARPP-binding protein) (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1)	CBY1 ARB1 C22orf2 CBY PGEA1 HRIHFB2025	Homo sapiens (Human)	126	FUNCTION: Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. {ECO:0000269|PubMed:12712206, ECO:0000269|PubMed:15194699}.	MISCELLANEOUS: 'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.	canonical Wnt signaling pathway [GO:0060070]; cardiac muscle cell differentiation [GO:0055007]; cilium assembly [GO:0060271]; fat cell differentiation [GO:0045444]; floor plate development [GO:0033504]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Wnt signaling pathway [GO:0030178]; protein homotetramerization [GO:0051289]; protein localization [GO:0008104]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]	beta-catenin binding [GO:0008013]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]; beta-catenin binding [GO:0008013]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle cell differentiation [GO:0055007]; cilium assembly [GO:0060271]; fat cell differentiation [GO:0045444]; floor plate development [GO:0033504]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Wnt signaling pathway [GO:0030178]; protein homotetramerization [GO:0051289]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:16424001}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27528616, ECO:0000269|PubMed:30395363}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:27528616}. Golgi apparatus. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:16424001}.
Q9Y3M8	reviewed	STA13_HUMAN	StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13)	STARD13 DLC2 GT650	Homo sapiens (Human)	1113	FUNCTION: GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}.		actin cytoskeleton organization [GO:0030036]; endothelial cell migration [GO:0043542]; endothelial tube lumen extension [GO:0097498]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]; lipid droplet [GO:0005811]; mitochondrial membrane [GO:0031966]	GTPase activator activity [GO:0005096]; lipid binding [GO:0008289]	cytosol [GO:0005829]; lipid droplet [GO:0005811]; mitochondrial membrane [GO:0031966]; GTPase activator activity [GO:0005096]; lipid binding [GO:0008289]; actin cytoskeleton organization [GO:0030036]; endothelial cell migration [GO:0043542]; endothelial tube lumen extension [GO:0097498]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
Q9Y3M9	reviewed	ZN337_HUMAN	Zinc finger protein 337	ZNF337	Homo sapiens (Human)	751	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y3P8	reviewed	SIT1_HUMAN	Signaling threshold-regulating transmembrane adapter 1 (SHP2-interacting transmembrane adapter protein) (Suppression-inducing transmembrane adapter 1) (gp30/40)	SIT1 SIT	Homo sapiens (Human)	196	FUNCTION: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. {ECO:0000269|PubMed:10209036}.		adaptive immune response [GO:0002250]; regulation of T cell activation [GO:0050863]; signal transduction [GO:0007165]; T cell homeostasis [GO:0043029]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	kinase binding [GO:0019900]; SH2 domain binding [GO:0042169]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; kinase binding [GO:0019900]; SH2 domain binding [GO:0042169]; adaptive immune response [GO:0002250]; regulation of T cell activation [GO:0050863]; signal transduction [GO:0007165]; T cell homeostasis [GO:0043029]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10209036}; Single-pass type I membrane protein {ECO:0000269|PubMed:10209036}.
Q9Y3P9	reviewed	RBGP1_HUMAN	Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA)	RABGAP1 HSPC094	Homo sapiens (Human)	1069	FUNCTION: May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}.		cell cycle [GO:0007049]; regulation of GTPase activity [GO:0043087]	centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; tubulin binding [GO:0015631]	centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; tubulin binding [GO:0015631]; cell cycle [GO:0007049]; regulation of GTPase activity [GO:0043087]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10202141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10202141}. Note=Predominantly cytosolic but also associated with the centrosome. {ECO:0000269|PubMed:10202141}.
Q9Y3Q0	reviewed	NALD2_HUMAN	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II)	NAALAD2	Homo sapiens (Human)	740	FUNCTION: Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate. {ECO:0000269|PubMed:10085079}.		proteolysis [GO:0006508]	membrane [GO:0016020]; plasma membrane [GO:0005886]	carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; dipeptidyl-peptidase activity [GO:0008239]; metal ion binding [GO:0046872]; metallocarboxypeptidase activity [GO:0004181]; serine-type peptidase activity [GO:0008236]	membrane [GO:0016020]; plasma membrane [GO:0005886]; carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; dipeptidyl-peptidase activity [GO:0008239]; metal ion binding [GO:0046872]; metallocarboxypeptidase activity [GO:0004181]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q04609}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q04609}.
Q9Y3Q3	reviewed	TMED3_HUMAN	Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26)	TMED3 C15orf22 UNQ5357/PRO1078	Homo sapiens (Human)	217	FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. {ECO:0000269|PubMed:10852829}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]	COPI vesicle coat [GO:0030126]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]		COPI vesicle coat [GO:0030126]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q6AY25}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000305|PubMed:16940185}; Single-pass type I membrane protein {ECO:0000255}. Note=Probably cycles between compartments of the early secretatory pathway. {ECO:0000269|PubMed:10852829}.
Q9Y3Q4	reviewed	HCN4_HUMAN	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	HCN4	Homo sapiens (Human)	1203	FUNCTION: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510, ECO:0000269|PubMed:19165230, ECO:0000269|PubMed:20829353}.	MISCELLANEOUS: Inhibited by extracellular cesium ions.	blood circulation [GO:0008015]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during SA node cell action potential [GO:0086046]; monoatomic cation transport [GO:0006812]; muscle contraction [GO:0006936]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; SA node cell action potential [GO:0086015]; sinoatrial node development [GO:0003163]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]	axon [GO:0030424]; dendrite [GO:0030425]; HCN channel complex [GO:0098855]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	cAMP binding [GO:0030552]; identical protein binding [GO:0042802]; intracellular cAMP-activated cation channel activity [GO:0005222]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated potassium channel activity involved in SA node cell action potential depolarization [GO:0086041]; voltage-gated sodium channel activity [GO:0005248]	axon [GO:0030424]; dendrite [GO:0030425]; HCN channel complex [GO:0098855]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cAMP binding [GO:0030552]; identical protein binding [GO:0042802]; intracellular cAMP-activated cation channel activity [GO:0005222]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated potassium channel activity involved in SA node cell action potential depolarization [GO:0086041]; voltage-gated sodium channel activity [GO:0005248]; blood circulation [GO:0008015]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during SA node cell action potential [GO:0086046]; monoatomic cation transport [GO:0006812]; muscle contraction [GO:0006936]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; SA node cell action potential [GO:0086015]; sinoatrial node development [GO:0003163]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510}; Multi-pass membrane protein {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510}.
Q9Y3Q7	reviewed	ADA18_HUMAN	Disintegrin and metalloproteinase domain-containing protein 18 (ADAM 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III) (tMDC III)	ADAM18 TMDC3 UNQ858/PRO1867	Homo sapiens (Human)	739	FUNCTION: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity). {ECO:0000250}.		binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; male gonad development [GO:0008584]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	membrane [GO:0016020]; plasma membrane [GO:0005886]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	membrane [GO:0016020]; plasma membrane [GO:0005886]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; male gonad development [GO:0008584]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9Y3Q8	reviewed	T22D4_HUMAN	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2)	TSC22D4 THG1 THG1-PIT	Homo sapiens (Human)	395	FUNCTION: Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}.		glucose homeostasis [GO:0042593]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron cellular homeostasis [GO:0070050]; neuron projection extension [GO:1990138]; response to osmotic stress [GO:0006970]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634]; synapse [GO:0045202]		cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634]; synapse [GO:0045202]; glucose homeostasis [GO:0042593]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron cellular homeostasis [GO:0070050]; neuron projection extension [GO:1990138]; response to osmotic stress [GO:0006970]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9EQN3}. Cytoplasm {ECO:0000250|UniProtKB:Q9EQN3}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9EQN3}. Synapse {ECO:0000250|UniProtKB:Q9EQN3}. Note=Localizes away from the nucleus to neurite processes and synaptic termini as cerebellar granular neurons differentiate (By similarity). Accumulates in the cytoplasm of differentiated Purkinje cells (By similarity). Localized to both the cytoplasm and nucleus in immature cerebellar granular neurons and atrophic Purkinje cells (By similarity). {ECO:0000250|UniProtKB:Q9EQN3}.
Q9Y3R0	reviewed	GRIP1_HUMAN	Glutamate receptor-interacting protein 1 (GRIP-1)	GRIP1	Homo sapiens (Human)	1128	FUNCTION: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P97879, ECO:0000269|PubMed:10197531}.		intracellular signal transduction [GO:0035556]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of neuron projection arborization [GO:0150012]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]	beta-catenin binding [GO:0008013]; signaling receptor complex adaptor activity [GO:0030159]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; beta-catenin binding [GO:0008013]; signaling receptor complex adaptor activity [GO:0030159]; intracellular signal transduction [GO:0035556]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of neuron projection arborization [GO:0150012]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:10197531}. Perikaryon {ECO:0000250|UniProtKB:P97879}. Cell projection, dendrite {ECO:0000250|UniProtKB:P97879}. Cytoplasm {ECO:0000250|UniProtKB:P97879}. Endomembrane system {ECO:0000250|UniProtKB:P97879}; Peripheral membrane protein {ECO:0000250|UniProtKB:P97879}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P97879}. Postsynaptic density {ECO:0000250|UniProtKB:P97879}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10197531}; Peripheral membrane protein {ECO:0000250|UniProtKB:P97879}. Note=Membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities. {ECO:0000250|UniProtKB:P97879}.
Q9Y3R4	reviewed	NEUR2_HUMAN	Sialidase-2 (EC 3.2.1.18) (Cytosolic sialidase) (N-acetyl-alpha-neuraminidase 2)	NEU2	Homo sapiens (Human)	380	FUNCTION: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed:14613940, PubMed:22228546). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form (PubMed:14613940). Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues (PubMed:14613940). {ECO:0000269|PubMed:14613940, ECO:0000269|PubMed:22228546}.		ganglioside catabolic process [GO:0006689]; glycoprotein catabolic process [GO:0006516]; glycosphingolipid metabolic process [GO:0006687]; oligosaccharide catabolic process [GO:0009313]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]; membrane [GO:0016020]	exo-alpha-(2->3)-sialidase activity [GO:0052794]; exo-alpha-(2->6)-sialidase activity [GO:0052795]; exo-alpha-(2->8)-sialidase activity [GO:0052796]; exo-alpha-sialidase activity [GO:0004308]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]; membrane [GO:0016020]; exo-alpha-(2->3)-sialidase activity [GO:0052794]; exo-alpha-(2->6)-sialidase activity [GO:0052795]; exo-alpha-(2->8)-sialidase activity [GO:0052796]; exo-alpha-sialidase activity [GO:0004308]; ganglioside catabolic process [GO:0006689]; glycoprotein catabolic process [GO:0006516]; glycosphingolipid metabolic process [GO:0006687]; oligosaccharide catabolic process [GO:0009313]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10561456}.
Q9Y3R5	reviewed	DOP2_HUMAN	Protein dopey-2	DOP1B C21orf5 DOPEY2 KIAA0933	Homo sapiens (Human)	2298	FUNCTION: May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}.		cognition [GO:0050890]; embryonic pattern specification [GO:0009880]; endoplasmic reticulum organization [GO:0007029]; Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]		cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; cognition [GO:0050890]; embryonic pattern specification [GO:0009880]; endoplasmic reticulum organization [GO:0007029]; Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:30213940}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q03921}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q03921}.
Q9Y3S1	reviewed	WNK2_HUMAN	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43)	WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13	Homo sapiens (Human)	2297	FUNCTION: Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.	MISCELLANEOUS: [Isoform 3]: Incomplete sequence. {ECO:0000269|PubMed:11280764}.	intracellular signal transduction [GO:0035556]; monoatomic ion homeostasis [GO:0050801]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; monoatomic ion homeostasis [GO:0050801]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598}. Cell membrane {ECO:0000269|PubMed:18593598}.
Q9Y3S2	reviewed	ZN330_HUMAN	Zinc finger protein 330 (Nucleolar autoantigen 36) (Nucleolar cysteine-rich protein)	ZNF330 NOA36	Homo sapiens (Human)	320				chromosome, centromeric region [GO:0000775]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]	chromosome, centromeric region [GO:0000775]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10593942}. Nucleus, nucleolus {ECO:0000269|PubMed:10593942}. Chromosome, centromere {ECO:0000269|PubMed:10593942}. Note=Predominantly expressed in the nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis.
Q9Y3T9	reviewed	NOC2L_HUMAN	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor)	NOC2L NIR	Homo sapiens (Human)	749	FUNCTION: Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}.		apoptotic process [GO:0006915]; cellular response to UV [GO:0034644]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ribosomal large subunit biogenesis [GO:0042273]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromosome [GO:0005694]; cytosol [GO:0005829]; Noc1p-Noc2p complex [GO:0030690]; Noc2p-Noc3p complex [GO:0030691]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]	chromosome [GO:0005694]; cytosol [GO:0005829]; Noc1p-Noc2p complex [GO:0030690]; Noc2p-Noc3p complex [GO:0030691]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; apoptotic process [GO:0006915]; cellular response to UV [GO:0034644]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ribosomal large subunit biogenesis [GO:0042273]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.
Q9Y3U8	reviewed	RL36_HUMAN	Large ribosomal subunit protein eL36 (60S ribosomal protein L36)	RPL36	Homo sapiens (Human)	105	FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.		cytoplasmic translation [GO:0002181]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; nucleolus [GO:0005730]; polysomal ribosome [GO:0042788]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; nucleolus [GO:0005730]; polysomal ribosome [GO:0042788]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Note=Detected on cytosolic polysomes (PubMed:25957688). {ECO:0000250|UniProtKB:Q2YGT9, ECO:0000269|PubMed:25957688}.
Q9Y3V2	reviewed	RWDD3_HUMAN	RWD domain-containing protein 3 (RWD domain-containing sumoylation enhancer) (RSUME)	RWDD3 RSUME	Homo sapiens (Human)	267	FUNCTION: Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination. {ECO:0000269|PubMed:17956732, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:23469069, ECO:0000269|PubMed:23508108}.		negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of hypoxia-inducible factor-1alpha signaling pathway [GO:1902073]; positive regulation of protein sumoylation [GO:0033235]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of hypoxia-inducible factor-1alpha signaling pathway [GO:1902073]; positive regulation of protein sumoylation [GO:0033235]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17956732}. Cytoplasm {ECO:0000269|PubMed:17956732}. Note=Colocalizes with UBC9/UBE2I in nuclear spots. {ECO:0000269|PubMed:17956732}.
Q9Y3Y2	reviewed	CHTOP_HUMAN	Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG)	CHTOP C1orf77 FOP HT031 PP7704	Homo sapiens (Human)	248	FUNCTION: Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:19858291, ECO:0000269|PubMed:20688955, ECO:0000269|PubMed:25284789}.; FUNCTION: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939). {ECO:0000269|PubMed:23299939}.		chromatin remodeling [GO:0006338]; mRNA export from nucleus [GO:0006406]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of helicase activity [GO:0051096]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex [GO:0000346]	methyl-CpG binding [GO:0008327]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex [GO:0000346]; methyl-CpG binding [GO:0008327]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; chromatin remodeling [GO:0006338]; mRNA export from nucleus [GO:0006406]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of helicase activity [GO:0051096]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19254951}. Nucleus, nucleolus {ECO:0000269|PubMed:19254951}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23826332}. Nucleus speckle {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:23826332}. Note=Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:23826332}.
Q9Y3Y4	reviewed	PYGO1_HUMAN	Pygopus homolog 1	PYGO1	Homo sapiens (Human)	419	FUNCTION: Involved in signal transduction through the Wnt pathway.		canonical Wnt signaling pathway [GO:0060070]; hematopoietic progenitor cell differentiation [GO:0002244]; kidney development [GO:0001822]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; spermatid nucleus differentiation [GO:0007289]	nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]	nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; canonical Wnt signaling pathway [GO:0060070]; hematopoietic progenitor cell differentiation [GO:0002244]; kidney development [GO:0001822]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; spermatid nucleus differentiation [GO:0007289]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y3Z3	reviewed	SAMH1_HUMAN	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1)	SAMHD1 MOP5	Homo sapiens (Human)	626	FUNCTION: Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:23602554, PubMed:23601106, PubMed:22056990, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:23602554, PubMed:23601106, PubMed:23364794, PubMed:25038827, PubMed:26101257, PubMed:22056990, PubMed:24336198, PubMed:28229507, PubMed:26294762, PubMed:26431200). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:29610582, PubMed:24217394). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23602554, PubMed:23601106, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). {ECO:0000250|UniProtKB:Q60710, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:21613998, ECO:0000269|PubMed:21720370, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:23364794, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:24336198, ECO:0000269|PubMed:25038827, ECO:0000269|PubMed:26101257, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:27477283, ECO:0000269|PubMed:28229507, ECO:0000269|PubMed:28834754, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289}.	MISCELLANEOUS: [Isoform 3]: Catalytically inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Catalytically inactive. {ECO:0000305}.	dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; deoxyribonucleotide catabolic process [GO:0009264]; dGTP catabolic process [GO:0006203]; DNA damage response [GO:0006974]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair via homologous recombination [GO:0000724]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein homotetramerization [GO:0051289]; regulation of innate immune response [GO:0045088]; somatic hypermutation of immunoglobulin genes [GO:0016446]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; tetraspanin-enriched microdomain [GO:0097197]	deoxynucleoside triphosphate hydrolase activity [GO:0106375]; dGTP binding [GO:0032567]; dGTPase activity [GO:0008832]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; single-stranded DNA binding [GO:0003697]; triphosphoric monoester hydrolase activity [GO:0016793]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; tetraspanin-enriched microdomain [GO:0097197]; deoxynucleoside triphosphate hydrolase activity [GO:0106375]; dGTP binding [GO:0032567]; dGTPase activity [GO:0008832]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; single-stranded DNA binding [GO:0003697]; triphosphoric monoester hydrolase activity [GO:0016793]; zinc ion binding [GO:0008270]; dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; deoxyribonucleotide catabolic process [GO:0009264]; dGTP catabolic process [GO:0006203]; DNA damage response [GO:0006974]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair via homologous recombination [GO:0000724]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein homotetramerization [GO:0051289]; regulation of innate immune response [GO:0045088]; somatic hypermutation of immunoglobulin genes [GO:0016446]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:23092512, ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396, ECO:0000269|PubMed:28229507, ECO:0000269|PubMed:28871089}. Chromosome {ECO:0000269|PubMed:28834754}. Note=Localizes to sites of DNA double-strand breaks in response to DNA damage. {ECO:0000269|PubMed:28834754}.
Q9Y446	reviewed	PKP3_HUMAN	Plakophilin-3	PKP3	Homo sapiens (Human)	797	FUNCTION: May play a role in junctional plaques.		cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; desmosome assembly [GO:0002159]; negative regulation of mRNA catabolic process [GO:1902373]; positive regulation of gene expression [GO:0010628]; protein localization to plasma membrane [GO:0072659]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; messenger ribonucleoprotein complex [GO:1990124]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; cadherin binding involved in cell-cell adhesion [GO:0098641]; cell adhesion molecule binding [GO:0050839]; enzyme binding [GO:0019899]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; messenger ribonucleoprotein complex [GO:1990124]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; cadherin binding involved in cell-cell adhesion [GO:0098641]; cell adhesion molecule binding [GO:0050839]; enzyme binding [GO:0019899]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; desmosome assembly [GO:0002159]; negative regulation of mRNA catabolic process [GO:1902373]; positive regulation of gene expression [GO:0010628]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes.
Q9Y448	reviewed	SKAP_HUMAN	Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1)	KNSTRN C15orf23 SKAP TRAF4AF1 HSD11	Homo sapiens (Human)	316	FUNCTION: Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}.		cell division [GO:0051301]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; chromosome segregation [GO:0007059]; microtubule cytoskeleton organization [GO:0000226]; mitotic sister chromatid segregation [GO:0000070]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; spindle organization [GO:0007051]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; spindle pole [GO:0000922]	microtubule plus-end binding [GO:0051010]; protein homodimerization activity [GO:0042803]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; spindle pole [GO:0000922]; microtubule plus-end binding [GO:0051010]; protein homodimerization activity [GO:0042803]; cell division [GO:0051301]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; chromosome segregation [GO:0007059]; microtubule cytoskeleton organization [GO:0000226]; mitotic sister chromatid segregation [GO:0000070]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24718257}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19667759}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:29180244}. Note=Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore-microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (PubMed:23035123). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123}.
Q9Y450	reviewed	HBS1L_HUMAN	HBS1-like protein (EC 3.6.5.-) (ERFS)	HBS1L HBS1 KIAA1038	Homo sapiens (Human)	684	FUNCTION: GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}.		nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; signal transduction [GO:0007165]; translation [GO:0006412]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; Dom34-Hbs1 complex [GO:1990533]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; Dom34-Hbs1 complex [GO:1990533]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; signal transduction [GO:0007165]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:21448132}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:28204585}.
Q9Y458	reviewed	TBX22_HUMAN	T-box transcription factor TBX22 (T-box protein 22)	TBX22 TBOX22	Homo sapiens (Human)	520	FUNCTION: Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.		cell fate specification [GO:0001708]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cell fate specification [GO:0001708]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Q9Y462	reviewed	ZN711_HUMAN	Zinc finger protein 711 (Zinc finger protein 6)	ZNF711 CMPX1 ZNF6	Homo sapiens (Human)	761	FUNCTION: Transcription regulator required for brain development (PubMed:20346720). Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed:20346720, PubMed:31691806). May compete with transcription factor ARX for activation of expression of KDM5C (PubMed:31691806). {ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:31691806}.		positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:20346720}.
Q9Y463	reviewed	DYR1B_HUMAN	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase)	DYRK1B MIRK	Homo sapiens (Human)	629	FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance (PubMed:33469661). During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2 (PubMed:32611815). Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). {ECO:0000269|PubMed:10910078, ECO:0000269|PubMed:11980910, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:24827035, ECO:0000269|PubMed:33469661}.		adipose tissue development [GO:0060612]; DNA repair [GO:0006281]; myoblast fusion [GO:0007520]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; transcription coactivator activity [GO:0003713]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; transcription coactivator activity [GO:0003713]; adipose tissue development [GO:0060612]; DNA repair [GO:0006281]; myoblast fusion [GO:0007520]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32611815, ECO:0000269|PubMed:33469661}. Nucleus, nucleolus {ECO:0000269|PubMed:33469661}. Chromosome {ECO:0000269|PubMed:32611815}. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. {ECO:0000269|PubMed:32611815}.
Q9Y466	reviewed	NR2E1_HUMAN	Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (hTll)	NR2E1 TLX	Homo sapiens (Human)	385	FUNCTION: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells. {ECO:0000250}.		aggressive behavior [GO:0002118]; amygdala development [GO:0021764]; anatomical structure development [GO:0048856]; angiogenesis [GO:0001525]; anterior commissure morphogenesis [GO:0021960]; apoptotic process [GO:0006915]; astrocyte cell migration [GO:0043615]; astrocyte differentiation [GO:0048708]; behavioral fear response [GO:0001662]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cerebral cortex neuron differentiation [GO:0021895]; dentate gyrus development [GO:0021542]; extracellular matrix organization [GO:0030198]; forebrain generation of neurons [GO:0021872]; layer formation in cerebral cortex [GO:0021819]; long-term synaptic potentiation [GO:0060291]; negative regulation of apoptotic process [GO:0043066]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; olfactory bulb development [GO:0021772]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell cycle [GO:0045787]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of stem cell proliferation [GO:2000648]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of dendrite morphogenesis [GO:0048814]; regulation of timing of neuron differentiation [GO:0060164]; retina development in camera-type eye [GO:0060041]; social behavior [GO:0035176]; somatic stem cell population maintenance [GO:0035019]; visual perception [GO:0007601]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; aggressive behavior [GO:0002118]; amygdala development [GO:0021764]; anatomical structure development [GO:0048856]; angiogenesis [GO:0001525]; anterior commissure morphogenesis [GO:0021960]; apoptotic process [GO:0006915]; astrocyte cell migration [GO:0043615]; astrocyte differentiation [GO:0048708]; behavioral fear response [GO:0001662]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cerebral cortex neuron differentiation [GO:0021895]; dentate gyrus development [GO:0021542]; extracellular matrix organization [GO:0030198]; forebrain generation of neurons [GO:0021872]; layer formation in cerebral cortex [GO:0021819]; long-term synaptic potentiation [GO:0060291]; negative regulation of apoptotic process [GO:0043066]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; olfactory bulb development [GO:0021772]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell cycle [GO:0045787]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of stem cell proliferation [GO:2000648]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of dendrite morphogenesis [GO:0048814]; regulation of timing of neuron differentiation [GO:0060164]; retina development in camera-type eye [GO:0060041]; social behavior [GO:0035176]; somatic stem cell population maintenance [GO:0035019]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Q9Y467	reviewed	SALL2_HUMAN	Sal-like protein 2 (Zinc finger protein 795) (Zinc finger protein SALL2) (Zinc finger protein Spalt-2) (Sal-2) (hSal2)	SALL2 KIAA0360 SAL2 ZNF795	Homo sapiens (Human)	1007	FUNCTION: Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure. {ECO:0000269|PubMed:24412933}.		eye development [GO:0001654]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; eye development [GO:0001654]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y468	reviewed	LMBL1_HUMAN	Lethal(3)malignant brain tumor-like protein 1 (H-l(3)mbt) (H-l(3)mbt protein) (L(3)mbt-like) (L(3)mbt protein homolog) (L3MBTL1)	L3MBTL1 KIAA0681 L3MBT L3MBTL	Homo sapiens (Human)	840	FUNCTION: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. {ECO:0000269|PubMed:17540172, ECO:0000269|PubMed:18408754, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:20870725}.	MISCELLANEOUS: The L3MBTL1 locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is silenced.	chromatin organization [GO:0006325]; hemopoiesis [GO:0030097]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of cell cycle [GO:0051726]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of mitotic nuclear division [GO:0007088]	chromatin [GO:0000785]; chromatin lock complex [GO:0061793]; condensed chromosome [GO:0000793]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; nucleosome binding [GO:0031491]; SAM domain binding [GO:0032093]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromatin lock complex [GO:0061793]; condensed chromosome [GO:0000793]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; nucleosome binding [GO:0031491]; SAM domain binding [GO:0032093]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; hemopoiesis [GO:0030097]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of cell cycle [GO:0051726]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of mitotic nuclear division [GO:0007088]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10445843}. Note=Excluded from the nucleolus. Does not colocalize with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex.
Q9Y473	reviewed	ZN175_HUMAN	Zinc finger protein 175 (Zinc finger protein OTK18)	ZNF175	Homo sapiens (Human)	711	FUNCTION: Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity. {ECO:0000269|PubMed:14688346}.		defense response to virus [GO:0051607]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; defense response to virus [GO:0051607]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q9Y478	reviewed	AAKB1_HUMAN	5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb)	PRKAB1 AMPK	Homo sapiens (Human)	270	FUNCTION: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).		cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; nail development [GO:0035878]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of gene expression [GO:0010628]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]	protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; nail development [GO:0035878]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of gene expression [GO:0010628]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	
Q9Y483	reviewed	MTF2_HUMAN	Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2)	MTF2 PCL2	Homo sapiens (Human)	593	FUNCTION: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250|UniProtKB:Q02395, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:31959557}.		cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029]; regulation of DNA-templated transcription [GO:0006355]; segment specification [GO:0007379]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]	cytoplasm [GO:0005737]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222]	cytoplasm [GO:0005737]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029]; regulation of DNA-templated transcription [GO:0006355]; segment specification [GO:0007379]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31959557}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:31959557}.
Q9Y484	reviewed	WIPI4_HUMAN	WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45)	WDR45 WDRX1 WDRXI4 WIPI4 JM5	Homo sapiens (Human)	360	FUNCTION: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066). {ECO:0000269|PubMed:23435086, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:31271352}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; nucleophagy [GO:0044804]; positive regulation of autophagosome assembly [GO:2000786]; protein localization to phagophore assembly site [GO:0034497]	cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]	phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein kinase binding [GO:0019901]	cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein kinase binding [GO:0019901]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; nucleophagy [GO:0044804]; positive regulation of autophagosome assembly [GO:2000786]; protein localization to phagophore assembly site [GO:0034497]	SUBCELLULAR LOCATION: Preautophagosomal structure {ECO:0000269|PubMed:21802374, ECO:0000269|PubMed:28561066}. Cytoplasm {ECO:0000269|PubMed:21802374}. Note=Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy. {ECO:0000269|PubMed:21802374}.
Q9Y487	reviewed	VPP2_HUMAN	V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)	ATP6V0A2	Homo sapiens (Human)	856	FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (PubMed:18157129). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:16415858, ECO:0000269|PubMed:18157129, ECO:0000269|PubMed:28296633}.		cellular response to increased oxygen levels [GO:0036295]; Golgi lumen acidification [GO:0061795]; immune response [GO:0006955]; intracellular iron ion homeostasis [GO:0006879]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; vacuolar acidification [GO:0007035]	acrosomal vesicle [GO:0001669]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	acrosomal vesicle [GO:0001669]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; cellular response to increased oxygen levels [GO:0036295]; Golgi lumen acidification [GO:0061795]; immune response [GO:0006955]; intracellular iron ion homeostasis [GO:0006879]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endosome membrane. Note=In kidney proximal tubules, also detected in subapical vesicles. {ECO:0000250}.
Q9Y490	reviewed	TLN1_HUMAN	Talin-1	TLN1 KIAA1027 TLN	Homo sapiens (Human)	2541	FUNCTION: High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). Involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: Shows reduced mechanical stability compared to isoform 1 (PubMed:36880935). Shows altered focal adhesion formation compared to isoform 1 with cells having a greater number of small adhesions compared to those expressing isoform 1 (PubMed:36880935). {ECO:0000269|PubMed:36880935}.; MISCELLANEOUS: [Isoform 2]: Expression in cancer cells is associated with altered drug responses. Cells show increased sensitivity to EGFR inhibitors but are resistant to drugs targeting PI3K signaling and cytoskeleton regulation. {ECO:0000269|PubMed:28251419}.	cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-substrate junction assembly [GO:0007044]; cortical actin cytoskeleton organization [GO:0030866]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; platelet aggregation [GO:0070527]; regulation of focal adhesion assembly [GO:0051893]	adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; integrin binding [GO:0005178]; LIM domain binding [GO:0030274]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; structural constituent of cytoskeleton [GO:0005200]; vinculin binding [GO:0017166]	adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; integrin binding [GO:0005178]; LIM domain binding [GO:0030274]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; structural constituent of cytoskeleton [GO:0005200]; vinculin binding [GO:0017166]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-substrate junction assembly [GO:0007044]; cortical actin cytoskeleton organization [GO:0030866]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; platelet aggregation [GO:0070527]; regulation of focal adhesion assembly [GO:0051893]	SUBCELLULAR LOCATION: Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:P26039}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P26039}. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity). {ECO:0000250}.
Q9Y493	reviewed	ZAN_HUMAN	Zonadhesin	ZAN	Homo sapiens (Human)	2812	FUNCTION: Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	binding of sperm to zona pellucida [GO:0007339]; cell-cell adhesion [GO:0098609]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; binding of sperm to zona pellucida [GO:0007339]; cell-cell adhesion [GO:0098609]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Exclusively on the apical region of the sperm head. {ECO:0000250}.
Q9Y496	reviewed	KIF3A_HUMAN	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A)	KIF3A KIF3	Homo sapiens (Human)	699	FUNCTION: Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. {ECO:0000250|UniProtKB:P28741}.		anterograde axonal transport [GO:0008089]; centriole-centriole cohesion [GO:0010457]; cilium assembly [GO:0060271]; microtubule anchoring at centrosome [GO:0034454]; organelle organization [GO:0006996]; plus-end-directed vesicle transport along microtubule [GO:0072383]; protein localization to cell junction [GO:1902414]; protein transport [GO:0015031]	axon cytoplasm [GO:1904115]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinesin complex [GO:0005871]; kinesin II complex [GO:0016939]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein phosphatase binding [GO:0019903]; small GTPase binding [GO:0031267]; spectrin binding [GO:0030507]	axon cytoplasm [GO:1904115]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinesin complex [GO:0005871]; kinesin II complex [GO:0016939]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein phosphatase binding [GO:0019903]; small GTPase binding [GO:0031267]; spectrin binding [GO:0030507]; anterograde axonal transport [GO:0008089]; centriole-centriole cohesion [GO:0010457]; cilium assembly [GO:0060271]; microtubule anchoring at centrosome [GO:0034454]; organelle organization [GO:0006996]; plus-end-directed vesicle transport along microtubule [GO:0072383]; protein localization to cell junction [GO:1902414]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:P28741}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23386061}. Note=Localizes to the subdistal appendage region of the centriole. {ECO:0000269|PubMed:23386061}.
Q9Y4A5	reviewed	TRRAP_HUMAN	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog)	TRRAP PAF400	Homo sapiens (Human)	3859	FUNCTION: Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). {ECO:0000250|UniProtKB:A0A0R4ITC5, ECO:0000269|PubMed:11418595, ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246, ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:9708738}.		chromatin organization [GO:0006325]; DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	Golgi apparatus [GO:0005794]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; Swr1 complex [GO:0000812]; transcription factor TFTC complex [GO:0033276]	transcription coregulator activity [GO:0003712]	Golgi apparatus [GO:0005794]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; Swr1 complex [GO:0000812]; transcription factor TFTC complex [GO:0033276]; transcription coregulator activity [GO:0003712]; chromatin organization [GO:0006325]; DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9708738}.
Q9Y4A8	reviewed	NF2L3_HUMAN	Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3)	NFE2L3 NRF3	Homo sapiens (Human)	694	FUNCTION: Activates erythroid-specific, globin gene expression.		integrated stress response signaling [GO:0140467]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; integrated stress response signaling [GO:0140467]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Q9Y4B4	reviewed	ARIP4_HUMAN	Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2)	RAD54L2 ARIP4 KIAA0809	Homo sapiens (Human)	1467	FUNCTION: DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}.			nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]	nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes in speckle-like nuclear compartments. {ECO:0000250}.
Q9Y4B5	reviewed	MTCL1_HUMAN	Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)	MTCL1 CCDC165 KIAA0802 SOGA2	Homo sapiens (Human)	1905	FUNCTION: Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. {ECO:0000269|PubMed:23902687}.		establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule bundle formation [GO:0001578]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of autophagy [GO:0010506]	apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; microtubule bundle [GO:0097427]; midbody [GO:0030496]; spindle pole [GO:0000922]	microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]	apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; microtubule bundle [GO:0097427]; midbody [GO:0030496]; spindle pole [GO:0000922]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule bundle formation [GO:0001578]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Lateral cell membrane {ECO:0000250}. Apical cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23902687}. Midbody {ECO:0000269|PubMed:23902687}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23902687}. Note=Colocalized with microtubules at the base of cilia. Gradually accumulates on the apicobasal microtubule bundles during epithelial cell polarization (By similarity). Colocalized with the apicobasal microtubule bundles running beneath the lateral membrane. Colocalized with microtubule bundles in the spindle pole in mitotic cells and in the midbodies at the end of cytokinesis. {ECO:0000250}.
Q9Y4B6	reviewed	DCAF1_HUMAN	DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein)	DCAF1 KIAA0800 RIP VPRBP	Homo sapiens (Human)	1507	FUNCTION: Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:23362280). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}.		B cell differentiation [GO:0030183]; cell competition in a multicellular organism [GO:0035212]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphorylation [GO:0016310]; positive regulation of protein catabolic process [GO:0045732]; post-translational protein modification [GO:0043687]; protein ubiquitination [GO:0016567]; V(D)J recombination [GO:0033151]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; histone H2AT120 kinase activity [GO:1990244]; nuclear estrogen receptor binding [GO:0030331]; protein serine kinase activity [GO:0106310]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; histone H2AT120 kinase activity [GO:1990244]; nuclear estrogen receptor binding [GO:0030331]; protein serine kinase activity [GO:0106310]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; B cell differentiation [GO:0030183]; cell competition in a multicellular organism [GO:0035212]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphorylation [GO:0016310]; positive regulation of protein catabolic process [GO:0045732]; post-translational protein modification [GO:0043687]; protein ubiquitination [GO:0016567]; V(D)J recombination [GO:0033151]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11223251}. Nucleus {ECO:0000269|PubMed:20178741}. Note=Associated with chromatin in a DDB1-independent and cell cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis. Homogenous pancellular distribution is observed outside S-phase and a slight cytoplasmic-to-nuclear translocation from early to late S-phase. Colocalizes with TET1 and PCNA at replicating heterochromatin during late S phase (By similarity). More concentrated in nuclei than in cytoplasm in germinal vesicle (GV) stage oocytes, zygotes and the 2-cell stage, but distributed in the cytoplasm at the MII-stage oocytes (By similarity). {ECO:0000250|UniProtKB:Q80TR8}.
Q9Y4C0	reviewed	NRX3A_HUMAN	Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha)	NRXN3 C14orf60 KIAA0743	Homo sapiens (Human)	1643	FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). {ECO:0000250|UniProtKB:Q9CS84}.	MISCELLANEOUS: [Isoform 3a]: Produced by alternative splicing. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4a]: Produced by alternative splicing. {ECO:0000305}.	adult behavior [GO:0030534]; axon guidance [GO:0007411]; learning [GO:0007612]; neuron cell-cell adhesion [GO:0007158]; social behavior [GO:0035176]; vocalization behavior [GO:0071625]	cell projection [GO:0042995]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; signaling receptor activity [GO:0038023]	cell projection [GO:0042995]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; signaling receptor activity [GO:0038023]; adult behavior [GO:0030534]; axon guidance [GO:0007411]; learning [GO:0007612]; neuron cell-cell adhesion [GO:0007158]; social behavior [GO:0035176]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9CS84}; Single-pass type I membrane protein {ECO:0000255}.
Q9Y4C1	reviewed	KDM3A_HUMAN	Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A)	KDM3A JHDM2A JMJD1 JMJD1A KIAA0742 TSGA	Homo sapiens (Human)	1321	FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}.		androgen receptor signaling pathway [GO:0030521]; cellular response to leukemia inhibitory factor [GO:1990830]; formaldehyde biosynthetic process [GO:0046293]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stem cell differentiation [GO:2000736]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid nucleus elongation [GO:0007290]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; iron ion binding [GO:0005506]; nuclear androgen receptor binding [GO:0050681]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; iron ion binding [GO:0005506]; nuclear androgen receptor binding [GO:0050681]; transcription coregulator activity [GO:0003712]; androgen receptor signaling pathway [GO:0030521]; cellular response to leukemia inhibitory factor [GO:1990830]; formaldehyde biosynthetic process [GO:0046293]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stem cell differentiation [GO:2000736]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid nucleus elongation [GO:0007290]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity). {ECO:0000250}.
Q9Y4C2	reviewed	TCAF1_HUMAN	TRPM8 channel-associated factor 1 (TRP channel-associated factor 1)	TCAF1 FAM115A KIAA0738	Homo sapiens (Human)	921	FUNCTION: Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner. {ECO:0000269|PubMed:25559186}.		negative regulation of cell migration [GO:0030336]; positive regulation of anion channel activity [GO:1901529]; positive regulation of protein targeting to membrane [GO:0090314]	plasma membrane [GO:0005886]	transmembrane transporter binding [GO:0044325]	plasma membrane [GO:0005886]; transmembrane transporter binding [GO:0044325]; negative regulation of cell migration [GO:0030336]; positive regulation of anion channel activity [GO:1901529]; positive regulation of protein targeting to membrane [GO:0090314]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25559186}. Note=Colocalizes with TRPM8 on the plasma membrane. {ECO:0000269|PubMed:25559186}.
Q9Y4C4	reviewed	MFHA1_HUMAN	Malignant fibrous histiocytoma-amplified sequence 1 (Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1)	MFHAS1 MASL1	Homo sapiens (Human)	1052	FUNCTION: Probable GTP-binding protein (PubMed:24286120). Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways (PubMed:26599367, PubMed:28471450, PubMed:28609714). Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor (PubMed:28609714). Both inhibits and activates the TLR2-dependent signaling pathway (PubMed:26599367). Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway (PubMed:29168081). Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway (PubMed:23327923). {ECO:0000269|PubMed:23327923, ECO:0000269|PubMed:24286120, ECO:0000269|PubMed:26599367, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:28609714, ECO:0000269|PubMed:29168081}.		erythrocyte differentiation [GO:0030218]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of protein dephosphorylation [GO:0035308]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; regulation of macrophage activation [GO:0043030]; regulation of toll-like receptor signaling pathway [GO:0034121]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]	GTP binding [GO:0005525]; protein phosphatase 2A binding [GO:0051721]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; GTP binding [GO:0005525]; protein phosphatase 2A binding [GO:0051721]; ubiquitin protein ligase binding [GO:0031625]; erythrocyte differentiation [GO:0030218]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of protein dephosphorylation [GO:0035308]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051897]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; regulation of macrophage activation [GO:0043030]; regulation of toll-like receptor signaling pathway [GO:0034121]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24286120}.
Q9Y4C5	reviewed	CHST2_HUMAN	Carbohydrate sulfotransferase 2 (EC 2.8.2.-) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2) (GST-2) (N-acetylglucosamine 6-O-sulfotransferase 1) (GlcNAc6ST-1) (Gn6ST-1)	CHST2 GN6ST	Homo sapiens (Human)	530	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. {ECO:0000269|PubMed:11042394, ECO:0000269|PubMed:11726653}.	MISCELLANEOUS: [Isoform 2]: Higher levels of expression compared to isoform 1 when expressed in HeLa cells. Exhibits similar intracellular GlcNAc-6-O-sulfation activity. {ECO:0000305}.	carbohydrate metabolic process [GO:0005975]; inflammatory response [GO:0006954]; keratan sulfate biosynthetic process [GO:0018146]; N-acetylglucosamine metabolic process [GO:0006044]; positive regulation of leukocyte tethering or rolling [GO:1903238]; sulfur compound metabolic process [GO:0006790]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]	N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146]; carbohydrate metabolic process [GO:0005975]; inflammatory response [GO:0006954]; keratan sulfate biosynthetic process [GO:0018146]; N-acetylglucosamine metabolic process [GO:0006044]; positive regulation of leukocyte tethering or rolling [GO:1903238]; sulfur compound metabolic process [GO:0006790]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12855678, ECO:0000269|PubMed:22260995}; Single-pass type II membrane protein {ECO:0000269|PubMed:12855678, ECO:0000269|PubMed:22260995}.
Q9Y4C8	reviewed	RBM19_HUMAN	Probable RNA-binding protein 19 (RNA-binding motif protein 19)	RBM19 KIAA0682	Homo sapiens (Human)	960	FUNCTION: Plays a role in embryo pre-implantation development. {ECO:0000250}.		mRNA splicing, via spliceosome [GO:0000398]; positive regulation of embryonic development [GO:0040019]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of embryonic development [GO:0040019]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16027046}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the nucleolar precursor body (NPB). During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development (By similarity). Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to NPB. {ECO:0000250}.
Q9Y4D1	reviewed	DAAM1_HUMAN	Disheveled-associated activator of morphogenesis 1	DAAM1 KIAA0666	Homo sapiens (Human)	1078	FUNCTION: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}.		actin cytoskeleton organization [GO:0030036]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	ciliary basal body [GO:0036064]; cytosol [GO:0005829]; membrane [GO:0016020]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	actin binding [GO:0003779]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]	ciliary basal body [GO:0036064]; cytosol [GO:0005829]; membrane [GO:0016020]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; actin binding [GO:0003779]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16630611}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:26644512}. Note=Perinuclear.
Q9Y4D2	reviewed	DGLA_HUMAN	Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha)	DAGLA C11orf11 KIAA0659 NSDDR	Homo sapiens (Human)	1042	FUNCTION: Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:26668358, PubMed:23502535). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:26668358, PubMed:23502535). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). {ECO:0000250|UniProtKB:Q6WQJ1, ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:26668358}.		arachidonic acid metabolic process [GO:0019369]; diacylglycerol catabolic process [GO:0046340]; endocannabinoid signaling pathway [GO:0071926]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; neuroblast proliferation [GO:0007405]; neurotransmitter biosynthetic process [GO:0042136]; regulation of neuroinflammatory response [GO:0150077]; retrograde trans-synaptic signaling by endocannabinoid [GO:0098921]	cytoplasm [GO:0005737]; dendrite membrane [GO:0032590]; dendritic spine membrane [GO:0032591]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; varicosity [GO:0043196]	acylglycerol lipase activity [GO:0047372]; lipoprotein lipase activity [GO:0004465]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; dendrite membrane [GO:0032590]; dendritic spine membrane [GO:0032591]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; varicosity [GO:0043196]; acylglycerol lipase activity [GO:0047372]; lipoprotein lipase activity [GO:0004465]; metal ion binding [GO:0046872]; arachidonic acid metabolic process [GO:0019369]; diacylglycerol catabolic process [GO:0046340]; endocannabinoid signaling pathway [GO:0071926]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; neuroblast proliferation [GO:0007405]; neurotransmitter biosynthetic process [GO:0042136]; regulation of neuroinflammatory response [GO:0150077]; retrograde trans-synaptic signaling by endocannabinoid [GO:0098921]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27595600}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic density membrane {ECO:0000269|PubMed:27595600}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:27595600}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q6WQJ1}; Multi-pass membrane protein {ECO:0000255}. Note=Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner. {ECO:0000269|PubMed:27595600}.
Q9Y4D7	reviewed	PLXD1_HUMAN	Plexin-D1	PLXND1 KIAA0620	Homo sapiens (Human)	1925	FUNCTION: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E. {ECO:0000250, ECO:0000269|PubMed:20385769}.		angiogenesis [GO:0001525]; aorta development [GO:0035904]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; endothelial cell migration [GO:0043542]; kidney development [GO:0001822]; negative regulation of cell adhesion [GO:0007162]; negative regulation of neuron apoptotic process [GO:0043524]; outflow tract morphogenesis [GO:0003151]; positive regulation of axonogenesis [GO:0050772]; regulation of angiogenesis [GO:0045765]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; synapse assembly [GO:0007416]; synaptic target recognition [GO:0008039]	axon [GO:0030424]; cell body [GO:0044297]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	protein domain specific binding [GO:0019904]; semaphorin receptor activity [GO:0017154]	axon [GO:0030424]; cell body [GO:0044297]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]; protein domain specific binding [GO:0019904]; semaphorin receptor activity [GO:0017154]; angiogenesis [GO:0001525]; aorta development [GO:0035904]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; endothelial cell migration [GO:0043542]; kidney development [GO:0001822]; negative regulation of cell adhesion [GO:0007162]; negative regulation of neuron apoptotic process [GO:0043524]; outflow tract morphogenesis [GO:0003151]; positive regulation of axonogenesis [GO:0050772]; regulation of angiogenesis [GO:0045765]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; synapse assembly [GO:0007416]; synaptic target recognition [GO:0008039]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3UH93}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q3UH93}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:24841563}.
Q9Y4D8	reviewed	HECD4_HUMAN	Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4)	HECTD4 C12orf51 KIAA0614	Homo sapiens (Human)	3996	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.		glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; protein ubiquitination [GO:0016567]	membrane [GO:0016020]	ubiquitin-protein transferase activity [GO:0004842]	membrane [GO:0016020]; ubiquitin-protein transferase activity [GO:0004842]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9Y4E1	reviewed	WAC2C_HUMAN	WASH complex subunit 2C (Vaccinia virus penetration factor) (VPEF)	WASHC2C FAM21C KIAA0592 VPEF	Homo sapiens (Human)	1341	FUNCTION: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission (PubMed:19922874, PubMed:20498093, PubMed:22513087, PubMed:23331060). Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35 (PubMed:24980502). Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L (PubMed:25355947, PubMed:28892079). {ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22513087, ECO:0000269|PubMed:23331060, ECO:0000269|PubMed:24980502, ECO:0000269|PubMed:25278552, ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.; FUNCTION: (Microbial infection) Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells. {ECO:0000269|PubMed:18550675}.	MISCELLANEOUS: In human, WASHC2 has undergone evolutionary duplication, with 2 highly homologous family members WASHC2A and WASHC2C. {ECO:0000305|PubMed:19922874}.	endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; negative regulation of barbed-end actin filament capping [GO:2000813]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; WASH complex [GO:0071203]	phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; retromer complex binding [GO:1905394]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; WASH complex [GO:0071203]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; retromer complex binding [GO:1905394]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; negative regulation of barbed-end actin filament capping [GO:2000813]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:20498093}. Cell membrane. Note=Partially colocalizes with RAB11A, a recycling endosome marker. Associates with lipid raft microdomains on the plasma membrane.
Q9Y4E5	reviewed	ZN451_HUMAN	E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451)	ZNF451 COASTER KIAA0576 KIAA1702	Homo sapiens (Human)	1061	FUNCTION: E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). {ECO:0000250|UniProtKB:Q8C0P7, ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267, ECO:0000269|PubMed:26524493, ECO:0000269|PubMed:26524494}.		negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein sumoylation [GO:0016925]	nucleus [GO:0005634]; PML body [GO:0016605]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; SUMO ligase activity [GO:0061665]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]	nucleus [GO:0005634]; PML body [GO:0016605]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; SUMO ligase activity [GO:0061665]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein sumoylation [GO:0016925]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267}. Nucleus, PML body {ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:36373674}. Nucleus, nucleoplasm. Note=Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules; this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location. {ECO:0000269|PubMed:18656483}.
Q9Y4E8	reviewed	UBP15_HUMAN	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)	USP15 KIAA0529	Homo sapiens (Human)	981	FUNCTION: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:21947082, PubMed:22344298, PubMed:24852371, PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067). {ECO:0000269|PubMed:16005295, ECO:0000269|PubMed:17318178, ECO:0000269|PubMed:19576224, ECO:0000269|PubMed:19826004, ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:22344298, ECO:0000269|PubMed:24526689, ECO:0000269|PubMed:24852371, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:33093067}.; FUNCTION: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. {ECO:0000269|PubMed:19553310}.		BMP signaling pathway [GO:0030509]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of antifungal innate immune response [GO:1905035]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of RIG-I signaling pathway [GO:1900246]; protein deubiquitination [GO:0016579]; protein K27-linked deubiquitination [GO:1990167]; regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1902238]; transcription elongation-coupled chromatin remodeling [GO:0140673]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; identical protein binding [GO:0042802]; K48-linked deubiquitinase activity [GO:1990380]; SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin modification-dependent histone binding [GO:0061649]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; identical protein binding [GO:0042802]; K48-linked deubiquitinase activity [GO:1990380]; SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin modification-dependent histone binding [GO:0061649]; BMP signaling pathway [GO:0030509]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of antifungal innate immune response [GO:1905035]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of RIG-I signaling pathway [GO:1900246]; protein deubiquitination [GO:0016579]; protein K27-linked deubiquitination [GO:1990167]; regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1902238]; transcription elongation-coupled chromatin remodeling [GO:0140673]; transforming growth factor beta receptor signaling pathway [GO:0007179]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:24526689}. Nucleus {ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:24526689}. Mitochondrion {ECO:0000269|PubMed:24852371}.
Q9Y4F1	reviewed	FARP1_HUMAN	FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2)	FARP1 CDEP PLEKHC2	Homo sapiens (Human)	1045	FUNCTION: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.		dendrite morphogenesis [GO:0048813]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of presynapse assembly [GO:1905606]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; synapse assembly [GO:0007416]	cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extrinsic component of postsynaptic membrane [GO:0098890]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]	cytoskeletal protein binding [GO:0008092]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extrinsic component of postsynaptic membrane [GO:0098890]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; cytoskeletal protein binding [GO:0008092]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; dendrite morphogenesis [GO:0048813]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of presynapse assembly [GO:1905606]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Synapse. Synapse, synaptosome {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Recruited to the cell membrane via interaction with CADM1. {ECO:0000250}.
Q9Y4F3	reviewed	MARF1_HUMAN	Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1)	MARF1 KIAA0430 LKAP	Homo sapiens (Human)	1742	FUNCTION: Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 5]: May be due to an intron retention. {ECO:0000305}.	double-strand break repair [GO:0006302]; female meiotic nuclear division [GO:0007143]; oogenesis [GO:0048477]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; peroxisome [GO:0005777]	CCR4-NOT complex binding [GO:1905762]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; peroxisome [GO:0005777]; CCR4-NOT complex binding [GO:1905762]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; double-strand break repair [GO:0006302]; female meiotic nuclear division [GO:0007143]; oogenesis [GO:0048477]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:15932519}.
Q9Y4F4	reviewed	TGRM1_HUMAN	TOG array regulator of axonemal microtubules protein 1 (Crescerin-1) (Protein FAM179B)	TOGARAM1 FAM179B KIAA0423	Homo sapiens (Human)	1720	FUNCTION: Involved in ciliogenesis (PubMed:32453716). It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (PubMed:32453716). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). {ECO:0000250|UniProtKB:Q17423, ECO:0000250|UniProtKB:Q6A070, ECO:0000269|PubMed:32453716}.		axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; non-motile cilium assembly [GO:1905515]; positive regulation of microtubule polymerization [GO:0031116]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881]	microtubule binding [GO:0008017]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881]; microtubule binding [GO:0008017]; axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; non-motile cilium assembly [GO:1905515]; positive regulation of microtubule polymerization [GO:0031116]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q6A070}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6A070}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:32453716}. Note=Detected along the length of primary cilia and at the basal body. Colocalization with the cytoplasmic microtubule cytoskeleton upon heterologous expression is most likely an artifact. {ECO:0000250|UniProtKB:Q6A070}.
Q9Y4F9	reviewed	RIPR2_HUMAN	Rho family-interacting cell polarization regulator 2	RIPOR2 C6orf32 DIFF48 FAM65B KIAA0386 PL48	Homo sapiens (Human)	1068	FUNCTION: Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:24687993, PubMed:23241886, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). {ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886, ECO:0000269|PubMed:24687993, ECO:0000269|PubMed:24958875, ECO:0000269|PubMed:27556504}.; FUNCTION: [Isoform 2]: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504). {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:25588844, ECO:0000269|PubMed:27556504}.	MISCELLANEOUS: Cells lacking isoform 2 exhibit a severe reduction of myotube formation. In contrast, isoform 2 overexpression induces formation of filopodia.	cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cellular response to chemokine [GO:1990869]; chemotaxis [GO:0006935]; muscle organ development [GO:0007517]; negative regulation of cell adhesion [GO:0007162]; negative regulation of establishment of T cell polarity [GO:1903904]; negative regulation of protein localization to cell leading edge [GO:1905872]; negative regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001107]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of T cell migration [GO:2000405]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil extravasation [GO:2000391]; regulation of cell cycle [GO:0051726]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitotic spindle assembly [GO:1901673]; sensory perception of sound [GO:0007605]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]	14-3-3 protein binding [GO:0071889]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; 14-3-3 protein binding [GO:0071889]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cellular response to chemokine [GO:1990869]; chemotaxis [GO:0006935]; muscle organ development [GO:0007517]; negative regulation of cell adhesion [GO:0007162]; negative regulation of establishment of T cell polarity [GO:1903904]; negative regulation of protein localization to cell leading edge [GO:1905872]; negative regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001107]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of T cell migration [GO:2000405]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil extravasation [GO:2000391]; regulation of cell cycle [GO:0051726]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitotic spindle assembly [GO:1901673]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17150207}. Cell projection, filopodium {ECO:0000269|PubMed:17150207}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q80U16}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q7TP54}. Apical cell membrane {ECO:0000250|UniProtKB:Q7TP54}. Note=Localized in the cytoplasm in cells undergoing mitosis (PubMed:17150207). Colocalized with F-actin (PubMed:17150207). Localized with RHOC within the basal domain of hair cell stereocilia, near the taper region (By similarity). Detected in punctate pattern forming a circumferential ring at the stereocilia base (By similarity). Localized to the apical stereocilia of inner and outer hair cells (By similarity). Not detected as a membrane-associated protein in stereocilia (By similarity). {ECO:0000250|UniProtKB:Q7TP54, ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:24687993}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:25588844}. Note=Accumulates at the leading edge of polarized neutrophils in a chemokine-dependent manner (PubMed:25588844). {ECO:0000269|PubMed:25588844}.
Q9Y4G2	reviewed	PKHM1_HUMAN	Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162)	PLEKHM1 KIAA0356	Homo sapiens (Human)	1056	FUNCTION: Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). {ECO:0000250|UniProtKB:Q5PQS0, ECO:0000250|UniProtKB:Q7TSI1, ECO:0000269|PubMed:12820725, ECO:0000269|PubMed:20943950, ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:28325809}.; FUNCTION: (Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7. {ECO:0000269|PubMed:25500191}.	MISCELLANEOUS: Sialyl-lex is a carcinoma associated antigen.	autophagosome-lysosome fusion [GO:0061909]; late endosome to lysosome transport [GO:1902774]; lysosome localization [GO:0032418]; positive regulation of bone resorption [GO:0045780]; positive regulation of ruffle assembly [GO:1900029]; protein transport [GO:0015031]	autolysosome [GO:0044754]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleolus [GO:0005730]	metal ion binding [GO:0046872]	autolysosome [GO:0044754]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleolus [GO:0005730]; metal ion binding [GO:0046872]; autophagosome-lysosome fusion [GO:0061909]; late endosome to lysosome transport [GO:1902774]; lysosome localization [GO:0032418]; positive regulation of bone resorption [GO:0045780]; positive regulation of ruffle assembly [GO:1900029]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Autolysosome membrane {ECO:0000269|PubMed:25498145}. Endosome membrane {ECO:0000269|PubMed:20943950}. Late endosome membrane {ECO:0000269|PubMed:28325809}. Lysosome membrane {ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:25500191, ECO:0000269|PubMed:28325809}. Note=In case of infection colocalizes with Salmonella typhimurium sifA in proximity of Salmonella-containing vacuole (SCV) (PubMed:25500191). {ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:25500191}.
Q9Y4G6	reviewed	TLN2_HUMAN	Talin-2	TLN2 KIAA0320	Homo sapiens (Human)	2542	FUNCTION: As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; synapse [GO:0045202]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; integrin binding [GO:0005178]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; synapse [GO:0045202]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; integrin binding [GO:0005178]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27223613}. Cell junction, focal adhesion {ECO:0000269|PubMed:12422219}. Synapse {ECO:0000269|PubMed:12422219}. Cell membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:12422219}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12422219}. Note=Focal adhesion plaques and synapses (PubMed:12422219). {ECO:0000269|PubMed:12422219}.
Q9Y4G8	reviewed	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)	RAPGEF2 KIAA0313 NRAPGEP PDZGEF1	Homo sapiens (Human)	1499	FUNCTION: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10608844, PubMed:10548487, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}.		adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; blood vessel development [GO:0001568]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; establishment of endothelial intestinal barrier [GO:0090557]; forebrain neuron development [GO:0021884]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of melanin biosynthetic process [GO:0048022]; nerve growth factor signaling pathway [GO:0038180]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; proteolysis [GO:0006508]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of cell junction assembly [GO:1901888]; regulation of synaptic plasticity [GO:0048167]; small GTPase mediated signal transduction [GO:0007264]; ventricular system development [GO:0021591]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; late endosome [GO:0005770]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]	beta-1 adrenergic receptor binding [GO:0031697]; calcium ion binding [GO:0005509]; cAMP binding [GO:0030552]; diacylglycerol binding [GO:0019992]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; phosphatidic acid binding [GO:0070300]; WW domain binding [GO:0050699]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; late endosome [GO:0005770]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; beta-1 adrenergic receptor binding [GO:0031697]; calcium ion binding [GO:0005509]; cAMP binding [GO:0030552]; diacylglycerol binding [GO:0019992]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; phosphatidic acid binding [GO:0070300]; WW domain binding [GO:0050699]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; blood vessel development [GO:0001568]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; establishment of endothelial intestinal barrier [GO:0090557]; forebrain neuron development [GO:0021884]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of melanin biosynthetic process [GO:0048022]; nerve growth factor signaling pathway [GO:0038180]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; proteolysis [GO:0006508]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of cell junction assembly [GO:1901888]; regulation of synaptic plasticity [GO:0048167]; small GTPase mediated signal transduction [GO:0007264]; ventricular system development [GO:0021591]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Late endosome. Cell junction {ECO:0000250}. Note=Associated with the synaptic plasma membrane. Colocalizes with ADRB1 at the plasma membrane. Synaptosome. Enriched in synaptic plasma membrane and neuronal cell body. Colocalized with CTNNB1 at cell-cell contacts (By similarity). Localized diffusely in the cytoplasm before neuronal growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with the high affinity nerve growth factor receptor NTRK1 at late endosomes. Translocated to the perinuclear region in a RAP1A-dependent manner. Translocated to the cell membrane. {ECO:0000250}.
Q9Y4H2	reviewed	IRS2_HUMAN	Insulin receptor substrate 2 (IRS-2)	IRS2	Homo sapiens (Human)	1338	FUNCTION: May mediate the control of various cellular processes by insulin.		brain development [GO:0007420]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; epithelial cell migration [GO:0010631]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; lipid homeostasis [GO:0055088]; mammary gland development [GO:0030879]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of kinase activity [GO:0033673]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucose import [GO:0046326]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin secretion [GO:0032024]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; regulation of lipid metabolic process [GO:0019216]; response to glucose [GO:0009749]; signal transduction [GO:0007165]; type B pancreatic cell proliferation [GO:0044342]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	14-3-3 protein binding [GO:0071889]; insulin receptor binding [GO:0005158]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; 14-3-3 protein binding [GO:0071889]; insulin receptor binding [GO:0005158]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; brain development [GO:0007420]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; epithelial cell migration [GO:0010631]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; lipid homeostasis [GO:0055088]; mammary gland development [GO:0030879]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of kinase activity [GO:0033673]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucose import [GO:0046326]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin secretion [GO:0032024]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; regulation of lipid metabolic process [GO:0019216]; response to glucose [GO:0009749]; signal transduction [GO:0007165]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
Q9Y4H4	reviewed	GPSM3_HUMAN	G-protein-signaling modulator 3 (Activator of G-protein signaling 4) (G18.1b) (Protein G18)	GPSM3 AGS4 C6orf9 G18	Homo sapiens (Human)	160	FUNCTION: Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins. {ECO:0000269|PubMed:14656218, ECO:0000269|PubMed:15096500}.		positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of inflammatory response [GO:0050729]; positive regulation of leukocyte chemotaxis [GO:0002690]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GTPase regulator activity [GO:0030695]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; GTPase regulator activity [GO:0030695]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of inflammatory response [GO:0050729]; positive regulation of leukocyte chemotaxis [GO:0002690]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15096500}.
Q9Y4I1	reviewed	MYO5A_HUMAN	Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin)	MYO5A MYH12	Homo sapiens (Human)	1855	FUNCTION: Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. {ECO:0000269|PubMed:10448864}.		actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; cellular response to insulin stimulus [GO:0032869]; melanosome transport [GO:0032402]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; vesicle transport along actin filament [GO:0030050]; vesicle-mediated transport [GO:0016192]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; insulin-responsive compartment [GO:0032593]; melanosome [GO:0042470]; membrane [GO:0016020]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; ruffle [GO:0001726]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; insulin-responsive compartment [GO:0032593]; melanosome [GO:0042470]; membrane [GO:0016020]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; ruffle [GO:0001726]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; cellular response to insulin stimulus [GO:0032869]; melanosome transport [GO:0032402]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; vesicle transport along actin filament [GO:0030050]; vesicle-mediated transport [GO:0016192]	
Q9Y4J8	reviewed	DTNA_HUMAN	Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3)	DTNA DRP3	Homo sapiens (Human)	743	FUNCTION: May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.		chemical synaptic transmission [GO:0007268]; neuromuscular synaptic transmission [GO:0007274]; signal transduction [GO:0007165]; striated muscle contraction [GO:0006941]; synaptic signaling [GO:0099536]	axon [GO:0030424]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202]	PDZ domain binding [GO:0030165]; zinc ion binding [GO:0008270]	axon [GO:0030424]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202]; PDZ domain binding [GO:0030165]; zinc ion binding [GO:0008270]; chemical synaptic transmission [GO:0007268]; neuromuscular synaptic transmission [GO:0007274]; signal transduction [GO:0007165]; striated muscle contraction [GO:0006941]; synaptic signaling [GO:0099536]	SUBCELLULAR LOCATION: Cytoplasm. Synapse. Cell membrane {ECO:0000250}. Note=In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane. {ECO:0000250}.
Q9Y4K0	reviewed	LOXL2_HUMAN	Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14)	LOXL2	Homo sapiens (Human)	774	FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (PubMed:27735137). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (PubMed:25959397). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (By similarity). Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3 (PubMed:16096638, PubMed:27735137, PubMed:24414204). During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction (PubMed:28332555). Involved in E-cadherin repression following hypoxia, a hallmark of EMT believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression (PubMed:20026874). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:20306300). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (PubMed:21835952). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:P58022, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20026874, ECO:0000269|PubMed:20306300, ECO:0000269|PubMed:21835952, ECO:0000269|PubMed:24239292, ECO:0000269|PubMed:24414204, ECO:0000269|PubMed:25959397, ECO:0000269|PubMed:27735137}.	MISCELLANEOUS: Its overexpression in a number of cancers and its ability to promote epithelial to mesenchymal transition suggest that LOXL2 might play a role in tumor progression: expression is correlated with metastasis and decreased survival in patients with aggressive breast cancer (PubMed:21233336, PubMed:21732535). Allosteric inhibition by AB0023 inhibits formation of the tumor microenvironment and reduces metastatic tumor burden in xenograft models (PubMed:20818376, PubMed:21732535). However, inhibiting the enzyme activity of LOXL2 may not be sufficient, since inhibition of keratinocyte differentiation is not prevented in mutants that lack enzyme activity nor by inhibition of activity by the AB0023 antibody, thereby promoting development of squamous cell carcinomas (PubMed:22157764). {ECO:0000305|PubMed:20818376, ECO:0000305|PubMed:21233336, ECO:0000305|PubMed:21732535, ECO:0000305|PubMed:22157764}.	collagen fibril organization [GO:0030199]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial to mesenchymal transition [GO:0001837]; heterochromatin organization [GO:0070828]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine oxidation [GO:0018057]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; protein modification process [GO:0036211]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]	basement membrane [GO:0005604]; chromatin [GO:0000785]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; oligosaccharide binding [GO:0070492]; protein-lysine 6-oxidase activity [GO:0004720]	basement membrane [GO:0005604]; chromatin [GO:0000785]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; oligosaccharide binding [GO:0070492]; protein-lysine 6-oxidase activity [GO:0004720]; collagen fibril organization [GO:0030199]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial to mesenchymal transition [GO:0001837]; heterochromatin organization [GO:0070828]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine oxidation [GO:0018057]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; protein modification process [GO:0036211]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:23319596}. Nucleus {ECO:0000269|PubMed:22204712, ECO:0000269|PubMed:24414204}. Chromosome {ECO:0000269|PubMed:27735137}. Endoplasmic reticulum {ECO:0000269|PubMed:28332555}. Note=Associated with chromatin (PubMed:27735137). It is unclear how LOXL2 is nuclear as it contains a signal sequence and has been shown to be secreted (PubMed:23319596). However, a number of reports confirm its intracellular location and its key role in transcription regulation (PubMed:22204712, PubMed:22483618). {ECO:0000269|PubMed:22204712, ECO:0000269|PubMed:23319596, ECO:0000269|PubMed:24414204, ECO:0000269|PubMed:27735137}.
Q9Y4K3	reviewed	TRAF6_HUMAN	TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)	TRAF6 RNF85	Homo sapiens (Human)	522	FUNCTION: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 (PubMed:31620128, PubMed:11057907, PubMed:18347055, PubMed:19713527, PubMed:19465916). Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (PubMed:19675569). Leads to the activation of NF-kappa-B and JUN (PubMed:16378096, PubMed:17135271, PubMed:17703191). Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes (PubMed:18093978, PubMed:18758450). Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (PubMed:8837778, PubMed:19825828, PubMed:12140561). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (By similarity). Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Participates also in the TCR signaling by ubiquitinating LAT (PubMed:25907557, PubMed:23514740). {ECO:0000250|UniProtKB:P70196, ECO:0000269|PubMed:11057907, ECO:0000269|PubMed:12140561, ECO:0000269|PubMed:16378096, ECO:0000269|PubMed:17135271, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:18093978, ECO:0000269|PubMed:18347055, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:19465916, ECO:0000269|PubMed:19675569, ECO:0000269|PubMed:19713527, ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557, ECO:0000269|PubMed:31620128, ECO:0000269|PubMed:8837778}.		activation of NF-kappaB-inducing kinase activity [GO:0007250]; activation of protein kinase activity [GO:0032147]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antiviral innate immune response [GO:0140374]; autophagosome assembly [GO:0000045]; bone resorption [GO:0045453]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; DNA damage response [GO:0006974]; Fc-epsilon receptor signaling pathway [GO:0038095]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; interleukin-33-mediated signaling pathway [GO:0038172]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; non-canonical NF-kappaB signal transduction [GO:0038061]; odontogenesis of dentin-containing tooth [GO:0042475]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of type I interferon production [GO:0032481]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of immunoglobulin production [GO:0002637]; response to interleukin-1 [GO:0070555]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	CD40 receptor complex [GO:0035631]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; protein kinase B binding [GO:0043422]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; protein kinase B binding [GO:0043422]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; activation of protein kinase activity [GO:0032147]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antiviral innate immune response [GO:0140374]; autophagosome assembly [GO:0000045]; bone resorption [GO:0045453]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cytosolic pattern recognition receptor signaling pathway [GO:0002753]; DNA damage response [GO:0006974]; Fc-epsilon receptor signaling pathway [GO:0038095]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; interleukin-33-mediated signaling pathway [GO:0038172]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; non-canonical NF-kappaB signal transduction [GO:0038061]; odontogenesis of dentin-containing tooth [GO:0042475]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of type I interferon production [GO:0032481]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of immunoglobulin production [GO:0002637]; response to interleukin-1 [GO:0070555]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18093978, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:24586164}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18093978}. Nucleus {ECO:0000269|PubMed:18093978}. Lipid droplet {ECO:0000250|UniProtKB:P70196}. Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
Q9Y4K4	reviewed	M4K5_HUMAN	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)	MAP4K5	Homo sapiens (Human)	846	FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}.		intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9038372}.
Q9Y4L1	reviewed	HYOU1_HUMAN	Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170)	HYOU1 GRP170 ORP150	Homo sapiens (Human)	999	FUNCTION: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. {ECO:0000269|PubMed:10037731}.		cellular response to hypoxia [GO:0071456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; response to endoplasmic reticulum stress [GO:0034976]; response to ischemia [GO:0002931]	endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; smooth endoplasmic reticulum [GO:0005790]	adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; smooth endoplasmic reticulum [GO:0005790]; adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; cellular response to hypoxia [GO:0071456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; response to endoplasmic reticulum stress [GO:0034976]; response to ischemia [GO:0002931]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
Q9Y4L5	reviewed	RN115_HUMAN	E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364)	RNF115 ZNF364	Homo sapiens (Human)	304	FUNCTION: E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4. {ECO:0000269|PubMed:16288031, ECO:0000269|PubMed:18819927, ECO:0000303|PubMed:23418353}.		negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D0C1}. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes. {ECO:0000250|UniProtKB:Q9D0C1}.
Q9Y4P1	reviewed	ATG4B_HUMAN	Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B)	ATG4B APG4B AUTL1 KIAA0943	Homo sapiens (Human)	393	FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:26378241, PubMed:29232556, PubMed:28821708, PubMed:30443548, PubMed:30661429, PubMed:22302004, PubMed:27527864, PubMed:28633005, PubMed:30076329). Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy (PubMed:33773106, PubMed:33909989). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:20818167, PubMed:19322194, PubMed:21177865, PubMed:22302004, PubMed:27527864, PubMed:28633005, PubMed:29458288, PubMed:30661429, PubMed:28287329). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004). Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (PubMed:31315929, PubMed:33773106). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:15187094, PubMed:28633005, PubMed:29458288, PubMed:32686895, PubMed:33909989, PubMed:19322194). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:15187094, PubMed:29458288, PubMed:32686895, PubMed:33909989, PubMed:19322194). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (PubMed:33909989). Compared to other members of the family (ATG4A, ATG4C or ATG4C), constitutes the major protein for proteolytic activation of ATG8 proteins, while it displays weaker delipidation activity than other ATG4 paralogs (PubMed:29458288, PubMed:30661429). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106). {ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:19322194, ECO:0000269|PubMed:20818167, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:22302004, ECO:0000269|PubMed:26378241, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28287329, ECO:0000269|PubMed:28633005, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29232556, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30076329, ECO:0000269|PubMed:30443548, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:31315929, ECO:0000269|PubMed:32686895, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}.		autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; lysosomal microautophagy [GO:0016237]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; otolith mineralization completed early in development [GO:0031173]; protein delipidation [GO:0051697]; protein localization to phagophore assembly site [GO:0034497]; protein transport [GO:0015031]; proteolysis [GO:0006508]; selective autophagy [GO:0061912]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]	cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786]; scaffold protein binding [GO:0097110]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786]; scaffold protein binding [GO:0097110]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; lysosomal microautophagy [GO:0016237]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; otolith mineralization completed early in development [GO:0031173]; protein delipidation [GO:0051697]; protein localization to phagophore assembly site [GO:0034497]; protein transport [GO:0015031]; proteolysis [GO:0006508]; selective autophagy [GO:0061912]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29165041}. Cytoplasm, cytosol {ECO:0000269|PubMed:29165041}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:29165041}. Endoplasmic reticulum {ECO:0000269|PubMed:29165041}. Mitochondrion {ECO:0000269|PubMed:29165041}. Note=Mainly localizes to the cytoplasm, including cytosol (PubMed:29165041). A samll potion localizes to mitochondria; phosphorylation at Ser-34 promotes localization to mitochondria (PubMed:29165041). {ECO:0000269|PubMed:29165041}.
Q9Y4P8	reviewed	WIPI2_HUMAN	WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2)	WIPI2 CGI-50	Homo sapiens (Human)	454	FUNCTION: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (PubMed:28890335). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066). {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:30968111}.; FUNCTION: [Isoform 4]: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. {ECO:0000269|PubMed:24954904}.		autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; nucleophagy [GO:0044804]; protein localization to phagophore assembly site [GO:0034497]; xenophagy [GO:0098792]	cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; nucleoplasm [GO:0005654]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; protein-containing complex [GO:0032991]	phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-5-phosphate binding [GO:0010314]	cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; nucleoplasm [GO:0005654]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; protein-containing complex [GO:0032991]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-5-phosphate binding [GO:0010314]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; nucleophagy [GO:0044804]; protein localization to phagophore assembly site [GO:0034497]; xenophagy [GO:0098792]	SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:23916833, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:33499712}; Peripheral membrane protein {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507}; Cytoplasmic side {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507}. Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. {ECO:0000269|PubMed:24954904}.
Q9Y4P9	reviewed	SPEF1_HUMAN	Sperm flagellar protein 1	SPEF1 C20orf28	Homo sapiens (Human)	236	FUNCTION: Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (By similarity). Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (PubMed:31473225). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity). {ECO:0000250|UniProtKB:Q0IH24, ECO:0000250|UniProtKB:Q99JL1, ECO:0000269|PubMed:31473225}.	MISCELLANEOUS: Radial intercalation is a developmentally reiterated form of migration by which cells move in a direction orthogonal to the plane of the tissue from an inner layer to an outer layer. {ECO:0000250|UniProtKB:Q0IH24}.	axonemal central apparatus assembly [GO:1904158]; cell migration [GO:0016477]; cilium movement [GO:0003341]; filopodium assembly [GO:0046847]; lamellipodium assembly [GO:0030032]; microtubule bundle formation [GO:0001578]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of cytoskeleton organization [GO:0051493]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]	9+2 motile cilium [GO:0097729]; apical plasma membrane [GO:0016324]; axonemal central apparatus [GO:1990716]; axoneme [GO:0005930]; basolateral plasma membrane [GO:0016323]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microvillus [GO:0005902]	actin binding [GO:0003779]; microtubule binding [GO:0008017]	9+2 motile cilium [GO:0097729]; apical plasma membrane [GO:0016324]; axonemal central apparatus [GO:1990716]; axoneme [GO:0005930]; basolateral plasma membrane [GO:0016323]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microvillus [GO:0005902]; actin binding [GO:0003779]; microtubule binding [GO:0008017]; axonemal central apparatus assembly [GO:1904158]; cell migration [GO:0016477]; cilium movement [GO:0003341]; filopodium assembly [GO:0046847]; lamellipodium assembly [GO:0030032]; microtubule bundle formation [GO:0001578]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of cytoskeleton organization [GO:0051493]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31473225}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q99JL1}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q0IH24}. Apical cell membrane {ECO:0000269|PubMed:31473225}. Basolateral cell membrane {ECO:0000269|PubMed:31473225}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:31473225}. Cell projection, microvillus {ECO:0000269|PubMed:31473225}. Cell projection, lamellipodium {ECO:0000269|PubMed:31473225}. Cell projection, filopodium {ECO:0000269|PubMed:31473225}. Note=Present in the tails of developing and epididymal sperm, internal to the fibrous sheath and around the outer dense fibers of the sperm flagellum. Also found at the apical tip of cilia (By similarity). Colocalizes with TJP1 and CGN at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225). {ECO:0000250|UniProtKB:Q0IH24, ECO:0000269|PubMed:31473225}.
Q9Y4R7	reviewed	TTLL3_HUMAN	Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3)	TTLL3 PRO0207	Homo sapiens (Human)	772	FUNCTION: Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin. Not involved in elongation step of the polyglycylation reaction (By similarity). Preferentially glycylates a beta-tail peptide over the alpha-tail, although shifts its preference toward alpha-tail as beta-tail glutamylation increases (By similarity). Competes with polyglutamylases for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (By similarity). Together with TTLL8, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance (By similarity). Involved in microtubule glycylation of primary cilia in colon which controls cell proliferation of epithelial cells and plays an essential role in colon cancer development (PubMed:25180231). Together with TTLL8, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility (By similarity). {ECO:0000250|UniProtKB:A4Q9E5, ECO:0000250|UniProtKB:B2GUB3, ECO:0000269|PubMed:25180231}.		axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]; protein modification process [GO:0036211]	axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; sperm flagellum [GO:0036126]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glycine ligase activity [GO:0070735]; protein-glycine ligase activity, initiating [GO:0070736]	axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; sperm flagellum [GO:0036126]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glycine ligase activity [GO:0070735]; protein-glycine ligase activity, initiating [GO:0070736]; axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]; protein modification process [GO:0036211]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25180231}. Cell projection, cilium {ECO:0000250|UniProtKB:A4Q9E5}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A4Q9E5}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A4Q9E5}.
Q9Y4R8	reviewed	TELO2_HUMAN	Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2)	TELO2 KIAA0683	Homo sapiens (Human)	837	FUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}.	MISCELLANEOUS: Cells overexpressing TELO2 are hypersensitive to hydroxyurea (HU) and undergo apoptotic death in response to treatment with HU.	positive regulation of DNA damage checkpoint [GO:2000003]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein stabilization [GO:0050821]; regulation of TOR signaling [GO:0032006]; telomere maintenance via telomerase [GO:0007004]	ASTRA complex [GO:0070209]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear periphery [GO:0034399]; nucleus [GO:0005634]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]; TTT complex [GO:0110078]	Hsp90 protein binding [GO:0051879]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; telomeric DNA binding [GO:0042162]	ASTRA complex [GO:0070209]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear periphery [GO:0034399]; nucleus [GO:0005634]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]; TTT complex [GO:0110078]; Hsp90 protein binding [GO:0051879]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; telomeric DNA binding [GO:0042162]; positive regulation of DNA damage checkpoint [GO:2000003]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein stabilization [GO:0050821]; regulation of TOR signaling [GO:0032006]; telomere maintenance via telomerase [GO:0007004]	SUBCELLULAR LOCATION: Cytoplasm. Membrane. Nucleus. Chromosome, telomere {ECO:0000305}.
Q9Y4U1	reviewed	MMAC_HUMAN	Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC)	MMACHC	Homo sapiens (Human)	282	FUNCTION: Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555). Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485). The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555). Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555). {ECO:0000269|PubMed:18779575, ECO:0000269|PubMed:19700356, ECO:0000269|PubMed:19801555, ECO:0000269|PubMed:21071249, ECO:0000269|PubMed:21697092, ECO:0000269|PubMed:22642810, ECO:0000269|PubMed:25809485, ECO:0000269|PubMed:27771510, ECO:0000303|PubMed:19801555, ECO:0000303|PubMed:25535791}.		cobalamin metabolic process [GO:0009235]; demethylation [GO:0070988]; glutathione metabolic process [GO:0006749]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	cobalamin binding [GO:0031419]; cyanocobalamin reductase (cyanide-eliminating) activity [GO:0033787]; demethylase activity [GO:0032451]; FAD binding [GO:0071949]; glutathione binding [GO:0043295]; oxidoreductase activity [GO:0016491]; protein homodimerization activity [GO:0042803]; transferase activity [GO:0016740]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cobalamin binding [GO:0031419]; cyanocobalamin reductase (cyanide-eliminating) activity [GO:0033787]; demethylase activity [GO:0032451]; FAD binding [GO:0071949]; glutathione binding [GO:0043295]; oxidoreductase activity [GO:0016491]; protein homodimerization activity [GO:0042803]; transferase activity [GO:0016740]; cobalamin metabolic process [GO:0009235]; demethylation [GO:0070988]; glutathione metabolic process [GO:0006749]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23270877}.
Q9Y4W2	reviewed	LAS1L_HUMAN	Ribosomal biogenesis protein LAS1L (Protein LAS1 homolog)	LAS1L MSTP060	Homo sapiens (Human)	734	FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22872859}.		maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]	Las1 complex [GO:0090730]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]	endonuclease activity [GO:0004519]; RNA binding [GO:0003723]	Las1 complex [GO:0090730]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]; endonuclease activity [GO:0004519]; RNA binding [GO:0003723]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20647540}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export. {ECO:0000250}.
Q9Y4W6	reviewed	AFG32_HUMAN	AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein)	AFG3L2	Homo sapiens (Human)	797	FUNCTION: ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048). Required for paraplegin (SPG7) maturation (PubMed:30252181). After its cleavage by mitochondrial-processing peptidase (MPP), it converts paraplegin into a proteolytically active mature form (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088, PubMed:30252181). Involved in the regulation of OMA1-dependent processing of OPA1 (PubMed:32600459, PubMed:30252181). Contributes to the proteolytic degradation of GHITM upon hyperpolarization of mitochondria (PubMed:35912435). Progressive GHITM degradation upon persistent hyperpolarization leads to respiratory complex I degradation and broad reshaping of the mitochondrial proteome by AFG3L2 (PubMed:35912435). {ECO:0000250|UniProtKB:Q8JZQ2, ECO:0000269|PubMed:22354088, ECO:0000269|PubMed:27642048, ECO:0000269|PubMed:30252181, ECO:0000269|PubMed:32600459, ECO:0000269|PubMed:35912435}.		axonogenesis [GO:0007409]; calcium import into the mitochondrion [GO:0036444]; cristae formation [GO:0042407]; membrane protein proteolysis [GO:0033619]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial fusion [GO:0008053]; mitochondrial protein processing [GO:0034982]; muscle cell development [GO:0055001]; myelination [GO:0042552]; nerve development [GO:0021675]; neuromuscular junction development [GO:0007528]; protein autoprocessing [GO:0016540]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of multicellular organism growth [GO:0040014]; righting reflex [GO:0060013]	m-AAA complex [GO:0005745]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]	m-AAA complex [GO:0005745]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]; axonogenesis [GO:0007409]; calcium import into the mitochondrion [GO:0036444]; cristae formation [GO:0042407]; membrane protein proteolysis [GO:0033619]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial fusion [GO:0008053]; mitochondrial protein processing [GO:0034982]; muscle cell development [GO:0055001]; myelination [GO:0042552]; nerve development [GO:0021675]; neuromuscular junction development [GO:0007528]; protein autoprocessing [GO:0016540]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of multicellular organism growth [GO:0040014]; righting reflex [GO:0060013]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10395799, ECO:0000269|PubMed:22354088}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8JZQ2}; Multi-pass membrane protein {ECO:0000255}.
Q9Y4X0	reviewed	AMMR1_HUMAN	Nuclear protein AMMECR1 (AMME syndrome candidate gene 1 protein)	AMMECR1	Homo sapiens (Human)	333				mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27811305}.
Q9Y4X3	reviewed	CCL27_HUMAN	C-C motif chemokine 27 (CC chemokine ILC) (Cutaneous T-cell-attracting chemokine) (CTACK) (ESkine) (IL-11 R-alpha-locus chemokine) (Skinkine) (Small-inducible cytokine A27)	CCL27 ILC SCYA27	Homo sapiens (Human)	112	FUNCTION: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.		cell-cell signaling [GO:0007267]; chemotaxis [GO:0006935]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	CCR3 chemokine receptor binding [GO:0031728]; chemokine activity [GO:0008009]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR3 chemokine receptor binding [GO:0031728]; chemokine activity [GO:0008009]; cell-cell signaling [GO:0007267]; chemotaxis [GO:0006935]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9Z1X0}.
Q9Y4X4	reviewed	KLF12_HUMAN	Krueppel-like factor 12 (Transcriptional repressor AP-2rep)	KLF12 AP2REP HSPC122	Homo sapiens (Human)	402	FUNCTION: Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q9Y4X5	reviewed	ARI1_HUMAN	E3 ubiquitin-protein ligase ARIH1 (EC 2.3.2.31) (H7-AP2) (HHARI) (Monocyte protein 6) (MOP-6) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein) (Ubiquitin-conjugating enzyme E2-binding protein 1)	ARIH1 ARI MOP6 UBCH7BP HUSSY-27	Homo sapiens (Human)	557	FUNCTION: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916). In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology (PubMed:29689197). {ECO:0000269|PubMed:14623119, ECO:0000269|PubMed:15236971, ECO:0000269|PubMed:17289916, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:23707686, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:29689197}.		positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lewy body [GO:0097413]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lewy body [GO:0097413]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11278816, ECO:0000269|PubMed:21590270, ECO:0000269|PubMed:23059369}. Nucleus {ECO:0000269|PubMed:23059369}. Nucleus, Cajal body {ECO:0000269|PubMed:23059369}. Note=Mainly cytoplasmic (PubMed:11278816). Present in Lewy body (PubMed:21590270). {ECO:0000269|PubMed:11278816, ECO:0000269|PubMed:21590270}.
Q9Y4Y9	reviewed	LSM5_HUMAN	U6 snRNA-associated Sm-like protein LSm5	LSM5	Homo sapiens (Human)	91	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.		mRNA catabolic process [GO:0006402]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; response to bacterium [GO:0009617]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]	protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; mRNA catabolic process [GO:0006402]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
Q9Y4Z0	reviewed	LSM4_HUMAN	U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)	LSM4	Homo sapiens (Human)	139	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.		mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process [GO:0000956]; P-body assembly [GO:0033962]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]	cytosol [GO:0005829]; Lsm2-8 complex [GO:0120115]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]	PH domain binding [GO:0042731]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070]	cytosol [GO:0005829]; Lsm2-8 complex [GO:0120115]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]; PH domain binding [GO:0042731]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process [GO:0000956]; P-body assembly [GO:0033962]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
Q9Y4Z2	reviewed	NGN3_HUMAN	Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5)	NEUROG3 ATOH5 BHLHA7 NGN3	Homo sapiens (Human)	214	FUNCTION: Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). {ECO:0000250}.		axon development [GO:0061564]; central nervous system development [GO:0007417]; epithelial cell differentiation [GO:0030855]; forebrain development [GO:0030900]; hindbrain development [GO:0030902]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; peripheral nervous system development [GO:0007422]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of dendrite morphogenesis [GO:0048814]; sensory organ development [GO:0007423]; spinal cord development [GO:0021510]; transdifferentiation [GO:0060290]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; axon development [GO:0061564]; central nervous system development [GO:0007417]; epithelial cell differentiation [GO:0030855]; forebrain development [GO:0030900]; hindbrain development [GO:0030902]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; peripheral nervous system development [GO:0007422]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of dendrite morphogenesis [GO:0048814]; sensory organ development [GO:0007423]; spinal cord development [GO:0021510]; transdifferentiation [GO:0060290]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q9Y508	reviewed	RN114_HUMAN	E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)	RNF114 ZNF228 ZNF313	Homo sapiens (Human)	228	FUNCTION: E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Acts also as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. {ECO:0000269|PubMed:23645206, ECO:0000269|PubMed:25165885, ECO:0000269|PubMed:28625874, ECO:0000269|PubMed:28708287}.		cell differentiation [GO:0030154]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; cell differentiation [GO:0030154]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23645206}. Nucleus {ECO:0000269|PubMed:23645206}.
Q9Y512	reviewed	SAM50_HUMAN	Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3)	SAMM50 SAM50 CGI-51 TRG3	Homo sapiens (Human)	469	FUNCTION: Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes (PubMed:22252321, PubMed:25781180). Required for the assembly of TOMM40 into the TOM complex (PubMed:15644312). {ECO:0000269|PubMed:15644312, ECO:0000269|PubMed:22252321, ECO:0000269|PubMed:25781180}.		cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial respiratory chain complex assembly [GO:0033108]; protein insertion into mitochondrial outer membrane [GO:0045040]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]		extracellular exosome [GO:0070062]; membrane [GO:0016020]; MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial respiratory chain complex assembly [GO:0033108]; protein insertion into mitochondrial outer membrane [GO:0045040]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:15644312}; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q6AXV4}. Mitochondrion {ECO:0000269|PubMed:25781180}.
Q9Y520	reviewed	PRC2C_HUMAN	Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C)	PRRC2C BAT2D1 BAT2L2 KIAA1096 XTP2	Homo sapiens (Human)	2896	FUNCTION: Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.		hematopoietic progenitor cell differentiation [GO:0002244]; stress granule assembly [GO:0034063]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]	RNA binding [GO:0003723]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; RNA binding [GO:0003723]; hematopoietic progenitor cell differentiation [GO:0002244]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm, Stress granule {ECO:0000305|PubMed:29395067}.
Q9Y530	reviewed	OARD1_HUMAN	ADP-ribose glycohydrolase OARD1 (O-acetyl-ADP-ribose deacetylase 1) (EC 3.5.1.-) (Terminal ADP-ribose protein glycohydrolase 1) ([Protein ADP-ribosylglutamate] hydrolase OARD1) (EC 3.2.2.-)	OARD1 C6orf130 TARG1	Homo sapiens (Human)	152	FUNCTION: ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose (PubMed:23481255, PubMed:23474714, PubMed:21849506). Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins (PubMed:23481255, PubMed:23474714). Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1 (PubMed:23481255). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21849506). Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively (PubMed:21849506). {ECO:0000269|PubMed:21849506, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255}.		DNA damage response [GO:0006974]; peptidyl-glutamate ADP-deribosylation [GO:0140291]; protein de-ADP-ribosylation [GO:0051725]; purine nucleoside metabolic process [GO:0042278]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of DNA damage [GO:0090734]	ADP-ribosylglutamate hydrolase activity [GO:0140293]; O-acetyl-ADP-ribose deacetylase activity [GO:0061463]; purine nucleoside binding [GO:0001883]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of DNA damage [GO:0090734]; ADP-ribosylglutamate hydrolase activity [GO:0140293]; O-acetyl-ADP-ribose deacetylase activity [GO:0061463]; purine nucleoside binding [GO:0001883]; DNA damage response [GO:0006974]; peptidyl-glutamate ADP-deribosylation [GO:0140291]; protein de-ADP-ribosylation [GO:0051725]; purine nucleoside metabolic process [GO:0042278]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:29712969}. Nucleus, nucleolus {ECO:0000269|PubMed:29712969}. Chromosome {ECO:0000269|PubMed:23481255}. Note=Localizes both in the nucleoplasm and in the nucleolus (PubMed:29712969). Relocalizes to the nucleoplasm in response to DNA damage (PubMed:29712969). Recruited to DNA lesion regions following DNA damage (PubMed:23481255). {ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:29712969}.
Q9Y535	reviewed	RPC8_HUMAN	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9)	POLR3H KIAA1665 RPC8	Homo sapiens (Human)	204	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; nucleobase-containing compound metabolic process [GO:0006139]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]	centrosome [GO:0005813]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]	centrosome [GO:0005813]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; nucleobase-containing compound metabolic process [GO:0006139]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]	SUBCELLULAR LOCATION: Nucleus.
Q9Y547	reviewed	IFT25_HUMAN	Intraflagellar transport protein 25 homolog (Heat shock protein beta-11) (Hspb11) (Placental protein 25) (PP25)	IFT25 C1orf41 HSPB11 HSPC034	Homo sapiens (Human)	144	FUNCTION: Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity). {ECO:0000250|UniProtKB:Q9D6H2}.		cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; heart development [GO:0007507]; intraciliary anterograde transport [GO:0035720]; kidney development [GO:0001822]; left/right axis specification [GO:0070986]; lung development [GO:0030324]; protein transport [GO:0015031]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]	metal ion binding [GO:0046872]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]; metal ion binding [GO:0046872]; cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; heart development [GO:0007507]; intraciliary anterograde transport [GO:0035720]; kidney development [GO:0001822]; left/right axis specification [GO:0070986]; lung development [GO:0030324]; protein transport [GO:0015031]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q9D6H2}.
Q9Y548	reviewed	YIPF1_HUMAN	Protein YIPF1 (YIP1 family member 1)	YIPF1	Homo sapiens (Human)	306			vesicle-mediated transport [GO:0016192]	Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; late endosome membrane [GO:0031902]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]	small GTPase binding [GO:0031267]	Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; late endosome membrane [GO:0031902]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]; small GTPase binding [GO:0031267]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27999994, ECO:0000269|PubMed:28286305}. Late endosome membrane {ECO:0000269|PubMed:27999994}. Note=Mainly localizes within medial-/trans-Golgi and trans-Golgi network (TGN), while less so within cis-Golgi. {ECO:0000269|PubMed:27999994, ECO:0000269|PubMed:28286305}.
Q9Y561	reviewed	LRP12_HUMAN	Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein)	LRP12 ST7	Homo sapiens (Human)	859	FUNCTION: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor. {ECO:0000269|PubMed:12809483}.		endocytosis [GO:0006897]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; regulation of growth [GO:0040008]; signal transduction [GO:0007165]	clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886]	low-density lipoprotein particle receptor activity [GO:0005041]	clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886]; low-density lipoprotein particle receptor activity [GO:0005041]; endocytosis [GO:0006897]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; regulation of growth [GO:0040008]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12809483}; Single-pass type I membrane protein {ECO:0000269|PubMed:12809483}. Membrane, coated pit {ECO:0000269|PubMed:12809483}.
Q9Y566	reviewed	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)	SHANK1	Homo sapiens (Human)	2161	FUNCTION: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.		adult behavior [GO:0030534]; associative learning [GO:0008306]; dendritic spine morphogenesis [GO:0060997]; determination of affect [GO:0050894]; habituation [GO:0046959]; long-term memory [GO:0007616]; negative regulation of actin filament bundle assembly [GO:0032232]; neuromuscular process controlling balance [GO:0050885]; olfactory behavior [GO:0042048]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; protein localization to synapse [GO:0035418]; protein-containing complex assembly [GO:0065003]; regulation of AMPA receptor activity [GO:2000311]; righting reflex [GO:0060013]; social behavior [GO:0035176]; synapse maturation [GO:0060074]; vocalization behavior [GO:0071625]	cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; Schaffer collateral - CA1 synapse [GO:0098685]	ankyrin repeat binding [GO:0071532]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; somatostatin receptor binding [GO:0031877]; structural constituent of postsynaptic density [GO:0098919]; synaptic receptor adaptor activity [GO:0030160]	cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; Schaffer collateral - CA1 synapse [GO:0098685]; ankyrin repeat binding [GO:0071532]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; somatostatin receptor binding [GO:0031877]; structural constituent of postsynaptic density [GO:0098919]; synaptic receptor adaptor activity [GO:0030160]; adult behavior [GO:0030534]; associative learning [GO:0008306]; dendritic spine morphogenesis [GO:0060997]; determination of affect [GO:0050894]; habituation [GO:0046959]; long-term memory [GO:0007616]; negative regulation of actin filament bundle assembly [GO:0032232]; neuromuscular process controlling balance [GO:0050885]; olfactory behavior [GO:0042048]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; protein localization to synapse [GO:0035418]; protein-containing complex assembly [GO:0065003]; regulation of AMPA receptor activity [GO:2000311]; righting reflex [GO:0060013]; social behavior [GO:0035176]; synapse maturation [GO:0060074]; vocalization behavior [GO:0071625]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Colocalizes with alpha-latrotoxin receptor 1. {ECO:0000250}.
Q9Y570	reviewed	PPME1_HUMAN	Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89)	PPME1 PME1 PP2593 PRO0750	Homo sapiens (Human)	386	FUNCTION: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}.		G2/M transition of mitotic cell cycle [GO:0000086]; protein demethylation [GO:0006482]	nucleoplasm [GO:0005654]	cadherin binding [GO:0045296]; lncRNA binding [GO:0106222]; protein C-terminal methylesterase activity [GO:0051722]; protein kinase binding [GO:0019901]; protein methylesterase activity [GO:0051723]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]	nucleoplasm [GO:0005654]; cadherin binding [GO:0045296]; lncRNA binding [GO:0106222]; protein C-terminal methylesterase activity [GO:0051722]; protein kinase binding [GO:0019901]; protein methylesterase activity [GO:0051723]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]; G2/M transition of mitotic cell cycle [GO:0000086]; protein demethylation [GO:0006482]	
Q9Y572	reviewed	RIPK3_HUMAN	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)	RIPK3 RIP3	Homo sapiens (Human)	518	FUNCTION: Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}.		activation of protein kinase activity [GO:0032147]; amyloid fibril formation [GO:1990000]; apoptotic signaling pathway [GO:0097190]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to hydrogen peroxide [GO:0070301]; defense response to virus [GO:0051607]; execution phase of necroptosis [GO:0097528]; lymph node development [GO:0048535]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of necroptotic process [GO:0060545]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatase activity [GO:0010922]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; programmed necrotic cell death [GO:0097300]; protein autophosphorylation [GO:0046777]; protein modification process [GO:0036211]; reactive oxygen species metabolic process [GO:0072593]; regulation of activated T cell proliferation [GO:0046006]; regulation of activation-induced cell death of T cells [GO:0070235]; regulation of adaptive immune response [GO:0002819]; regulation of apoptotic process [GO:0042981]; regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [GO:2000452]; regulation of T cell mediated cytotoxicity [GO:0001914]; regulation of type II interferon production [GO:0032649]; signal transduction [GO:0007165]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; NF-kappaB-inducing kinase activity [GO:0004704]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; NF-kappaB-inducing kinase activity [GO:0004704]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; activation of protein kinase activity [GO:0032147]; amyloid fibril formation [GO:1990000]; apoptotic signaling pathway [GO:0097190]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to hydrogen peroxide [GO:0070301]; defense response to virus [GO:0051607]; execution phase of necroptosis [GO:0097528]; lymph node development [GO:0048535]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of necroptotic process [GO:0060545]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatase activity [GO:0010922]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; programmed necrotic cell death [GO:0097300]; protein autophosphorylation [GO:0046777]; protein modification process [GO:0036211]; reactive oxygen species metabolic process [GO:0072593]; regulation of activated T cell proliferation [GO:0046006]; regulation of activation-induced cell death of T cells [GO:0070235]; regulation of adaptive immune response [GO:0002819]; regulation of apoptotic process [GO:0042981]; regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [GO:2000452]; regulation of T cell mediated cytotoxicity [GO:0001914]; regulation of type II interferon production [GO:0032649]; signal transduction [GO:0007165]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22265413}. Nucleus {ECO:0000250|UniProtKB:Q9QZL0}. Note=Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection. {ECO:0000250|UniProtKB:Q9QZL0}.
Q9Y574	reviewed	ASB4_HUMAN	Ankyrin repeat and SOCS box protein 4 (ASB-4)	ASB4	Homo sapiens (Human)	426	FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity). {ECO:0000250}.		intracellular signal transduction [GO:0035556]; positive regulation of vasculogenesis [GO:2001214]; protein autoubiquitination [GO:0051865]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; intracellular signal transduction [GO:0035556]; positive regulation of vasculogenesis [GO:2001214]; protein autoubiquitination [GO:0051865]	
Q9Y575	reviewed	ASB3_HUMAN	Ankyrin repeat and SOCS box protein 3 (ASB-3)	ASB3	Homo sapiens (Human)	518	FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. {ECO:0000269|PubMed:15899873}.		intracellular signal transduction [GO:0035556]; protein localization to T-tubule [GO:0036371]; protein ubiquitination [GO:0016567]; regulation of cardiac muscle contraction [GO:0055117]	cytosol [GO:0005829]; T-tubule [GO:0030315]		cytosol [GO:0005829]; T-tubule [GO:0030315]; intracellular signal transduction [GO:0035556]; protein localization to T-tubule [GO:0036371]; protein ubiquitination [GO:0016567]; regulation of cardiac muscle contraction [GO:0055117]	
Q9Y576	reviewed	ASB1_HUMAN	Ankyrin repeat and SOCS box protein 1 (ASB-1)	ASB1 KIAA1146	Homo sapiens (Human)	335	FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:16325183). Mediates Notch-induced ubiquitination and degradation of TCF3/E2A and JAK2 (PubMed:21119685). May play a role in testis development (By similarity). {ECO:0000250|UniProtKB:Q9WV74, ECO:0000269|PubMed:16325183, ECO:0000269|PubMed:21119685}.		intracellular signal transduction [GO:0035556]; male genitalia development [GO:0030539]; negative regulation of cytokine production [GO:0001818]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]		cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]; intracellular signal transduction [GO:0035556]; male genitalia development [GO:0030539]; negative regulation of cytokine production [GO:0001818]; protein ubiquitination [GO:0016567]	
Q9Y577	reviewed	TRI17_HUMAN	E3 ubiquitin-protein ligase TRIM17 (EC 2.3.2.27) (RING finger protein 16) (RING-type E3 ubiquitin transferase TRIM17) (Testis RING finger protein) (Tripartite motif-containing protein 17)	TRIM17 RBCC RNF16 TERF	Homo sapiens (Human)	477	FUNCTION: E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation (PubMed:22023800, PubMed:19358823, PubMed:27562068). Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation (PubMed:22023800). Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (PubMed:27562068). Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (By similarity). Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (PubMed:19358823). {ECO:0000250|UniProtKB:Q7TPM3, ECO:0000269|PubMed:19358823, ECO:0000269|PubMed:22023800, ECO:0000269|PubMed:27562068}.		autophagy [GO:0006914]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]	protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; autophagy [GO:0006914]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27562068}. Lysosome {ECO:0000269|PubMed:27562068}.
Q9Y580	reviewed	RBM7_HUMAN	RNA-binding protein 7 (RNA-binding motif protein 7)	RBM7	Homo sapiens (Human)	266	FUNCTION: RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation (PubMed:25189701, PubMed:25578728, PubMed:25525152, PubMed:25852104, PubMed:27871484). NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:25189701, PubMed:27871484, PubMed:25852104). Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs) (PubMed:25189701, PubMed:25578728, PubMed:25525152, PubMed:25852104). Participates in several biological processes including DNA damage response (DDR) and stress response (PubMed:25525152, PubMed:30824372). During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome (PubMed:25525152). Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability (PubMed:30824372). {ECO:0000269|PubMed:25189701, ECO:0000269|PubMed:25525152, ECO:0000269|PubMed:25578728, ECO:0000269|PubMed:25852104, ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:30824372}.		meiotic cell cycle [GO:0051321]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; snRNA catabolic process [GO:0016076]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	14-3-3 protein binding [GO:0071889]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; snRNA binding [GO:0017069]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 14-3-3 protein binding [GO:0071889]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; snRNA binding [GO:0017069]; meiotic cell cycle [GO:0051321]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; snRNA catabolic process [GO:0016076]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:25852104}. Nucleus {ECO:0000250|UniProtKB:Q9CQT2}. Note=Excluded from the nucleolus. {ECO:0000269|PubMed:21855801}.
Q9Y584	reviewed	TIM22_HUMAN	Mitochondrial import inner membrane translocase subunit Tim22 (Testis-expressed protein 4)	TIMM22 TEX4 TIM22	Homo sapiens (Human)	194	FUNCTION: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). {ECO:0000250|UniProtKB:Q12328}.		protein insertion into mitochondrial inner membrane [GO:0045039]	mitochondrial inner membrane [GO:0005743]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]	mitochondrion targeting sequence binding [GO:0030943]; protein transmembrane transporter activity [GO:0008320]; protein transporter activity [GO:0140318]	mitochondrial inner membrane [GO:0005743]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]; mitochondrion targeting sequence binding [GO:0030943]; protein transmembrane transporter activity [GO:0008320]; protein transporter activity [GO:0140318]; protein insertion into mitochondrial inner membrane [GO:0045039]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:27265872}; Multi-pass membrane protein {ECO:0000255}.
Q9Y586	reviewed	MB212_HUMAN	Protein mab-21-like 2	MAB21L2	Homo sapiens (Human)	359	FUNCTION: Required for several aspects of embryonic development including normal development of the eye. {ECO:0000269|PubMed:24906020, ECO:0000269|PubMed:25719200}.		camera-type eye development [GO:0043010]; cell population proliferation [GO:0008283]; embryonic body morphogenesis [GO:0010172]; eye development [GO:0001654]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; camera-type eye development [GO:0043010]; cell population proliferation [GO:0008283]; embryonic body morphogenesis [GO:0010172]; eye development [GO:0001654]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25719200}. Cytoplasm {ECO:0000269|PubMed:25719200}. Note=Predominantly localizes to the nucleus, with some cytoplasmic localization (PubMed:25719200). {ECO:0000269|PubMed:25719200}.
Q9Y587	reviewed	AP4S1_HUMAN	AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin)	AP4S1	Homo sapiens (Human)	144	FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}.		protein localization [GO:0008104]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192]	AP-4 adaptor complex [GO:0030124]; endosome lumen [GO:0031904]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]		AP-4 adaptor complex [GO:0030124]; endosome lumen [GO:0031904]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; protein localization [GO:0008104]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000305|PubMed:10436028}; Peripheral membrane protein {ECO:0000305}.
Q9Y592	reviewed	CEP83_HUMAN	Centrosomal protein of 83 kDa (Cep83) (Coiled-coil domain-containing protein 41) (Renal carcinoma antigen NY-REN-58)	CEP83 CCDC41	Homo sapiens (Human)	701	FUNCTION: Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23530209}.		cilium assembly [GO:0060271]; establishment of centrosome localization [GO:0051660]; protein localization to centrosome [GO:0071539]; vesicle docking [GO:0048278]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]	identical protein binding [GO:0042802]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; identical protein binding [GO:0042802]; cilium assembly [GO:0060271]; establishment of centrosome localization [GO:0051660]; protein localization to centrosome [GO:0071539]; vesicle docking [GO:0048278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23530209}. Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to centrioles at all stages of the cell cycle, including mitosis.
Q9Y5A6	reviewed	ZSC21_HUMAN	Zinc finger and SCAN domain-containing protein 21 (Renal carcinoma antigen NY-REN-21) (Zinc finger protein 38 homolog) (Zfp-38)	ZSCAN21 ZFP38 ZNF38	Homo sapiens (Human)	473	FUNCTION: Strong transcriptional activator (By similarity). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity). {ECO:0000250|UniProtKB:Q07231}.		cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q9Y5A7	reviewed	NUB1_HUMAN	NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18)	NUB1 NYREN18	Homo sapiens (Human)	615	FUNCTION: Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. {ECO:0000269|PubMed:16707496}.		positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11259415}. Note=Predominantly nuclear.
Q9Y5A9	reviewed	YTHD2_HUMAN	YTH domain-containing family protein 2 (DF2) (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2)	YTHDF2 HGRG8	Homo sapiens (Human)	579	FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:24284625, PubMed:26046440, PubMed:26318451, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:32492408, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context (PubMed:24284625, PubMed:26046440, PubMed:27558897, PubMed:30930054, PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex (PubMed:30930054). Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs (PubMed:27558897). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity). Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases (By similarity). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation (PubMed:30065315). Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (By similarity). Inhibits neural specification of induced pluripotent stem cells by binding to methylated neural-specific mRNAs and promoting their degradation, thereby restraining neural differentiation (PubMed:32169943). Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts (PubMed:30428350). Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation (PubMed:30559377). May also act as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103). Regulates mitotic entry by promoting the phase-specific m6A-dependent degradation of WEE1 transcripts (PubMed:32267835). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31388144, PubMed:31292544, PubMed:32451507, PubMed:31642031). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind RNAs modified by C5-methylcytosine (m5C) and act as a regulator of rRNA processing (PubMed:31815440). {ECO:0000250|UniProtKB:Q91YT7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25412658, ECO:0000269|PubMed:25412661, ECO:0000269|PubMed:26046440, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:30065315, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:30930054, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:31642031, ECO:0000269|PubMed:31815440, ECO:0000269|PubMed:32169943, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: (Microbial infection) Promotes viral gene expression and replication of polyomavirus SV40: acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29447282). {ECO:0000269|PubMed:29447282}.; FUNCTION: (Microbial infection) Promotes viral gene expression and virion production of kaposis sarcoma-associated herpesvirus (KSHV) at some stage of the KSHV life cycle (in iSLK.219 and iSLK.BAC16 cells) (PubMed:29659627). Acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29659627). {ECO:0000269|PubMed:29659627}.		cell cycle [GO:0007049]; embryonic morphogenesis [GO:0048598]; endothelial to hematopoietic transition [GO:0098508]; gamete generation [GO:0007276]; hematopoietic stem cell proliferation [GO:0071425]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; oocyte maturation [GO:0001556]; organelle assembly [GO:0070925]; positive regulation of cap-independent translational initiation [GO:1903679]; regulation of cell adhesion [GO:0030155]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of meiotic cell cycle process involved in oocyte maturation [GO:1903538]; regulation of mRNA stability [GO:0043488]; regulation of neurogenesis [GO:0050767]; regulation of rRNA processing [GO:2000232]; spermatogonial cell division [GO:0007284]; stress granule assembly [GO:0034063]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]	C5-methylcytidine-containing RNA binding [GO:0062153]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; C5-methylcytidine-containing RNA binding [GO:0062153]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]; cell cycle [GO:0007049]; embryonic morphogenesis [GO:0048598]; endothelial to hematopoietic transition [GO:0098508]; gamete generation [GO:0007276]; hematopoietic stem cell proliferation [GO:0071425]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; oocyte maturation [GO:0001556]; organelle assembly [GO:0070925]; positive regulation of cap-independent translational initiation [GO:1903679]; regulation of cell adhesion [GO:0030155]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of meiotic cell cycle process involved in oocyte maturation [GO:1903538]; regulation of mRNA stability [GO:0043488]; regulation of neurogenesis [GO:0050767]; regulation of rRNA processing [GO:2000232]; spermatogonial cell division [GO:0007284]; stress granule assembly [GO:0034063]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:32492408}. Cytoplasm, P-body {ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:32492408}. Cytoplasm, Stress granule {ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:32451507}. Nucleus {ECO:0000269|PubMed:26458103}. Note=Localizes to the cytosol and relocates to the nucleus following heat shock stress (PubMed:26458103). Can partition into different structures: into P-bodies in unstressed cells, and into stress granules during stress (PubMed:31292544). {ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:31292544}.
Q9Y5B0	reviewed	CTDP1_HUMAN	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase)	CTDP1 FCP1	Homo sapiens (Human)	961	FUNCTION: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}.		cell division [GO:0051301]; exit from mitosis [GO:0010458]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; positive regulation by host of viral transcription [GO:0043923]; protein dephosphorylation [GO:0006470]; transcription elongation by RNA polymerase II [GO:0006368]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]	myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; Tat protein binding [GO:0030957]; TFIIF-class transcription factor complex binding [GO:0001096]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; Tat protein binding [GO:0030957]; TFIIF-class transcription factor complex binding [GO:0001096]; cell division [GO:0051301]; exit from mitosis [GO:0010458]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; positive regulation by host of viral transcription [GO:0043923]; protein dephosphorylation [GO:0006470]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22692537}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22692537}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:22692537}. Midbody {ECO:0000269|PubMed:22692537}. Note=Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively.
Q9Y5B6	reviewed	PAXB1_HUMAN	PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1)	PAXBP1 C21orf66 GCFC GCFC1	Homo sapiens (Human)	917	FUNCTION: Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 4]: Most abundantly expressed isoform, at mRNA level according to PubMed:11707072, despite the presence of a premature stop codon in the mRNA that may lead to nonsense-mediated mRNA decay. {ECO:0000305}.	mRNA splicing, via spliceosome [GO:0000398]; muscle organ development [GO:0007517]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; transcription by RNA polymerase II [GO:0006366]	cytosol [GO:0005829]; nucleus [GO:0005634]	DNA binding [GO:0003677]; histone methyltransferase binding [GO:1990226]	cytosol [GO:0005829]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone methyltransferase binding [GO:1990226]; mRNA splicing, via spliceosome [GO:0000398]; muscle organ development [GO:0007517]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9Y5B8	reviewed	NDK7_HUMAN	Nucleoside diphosphate kinase 7 (NDK 7) (NDP kinase 7) (EC 2.7.4.6) (nm23-H7)	NME7	Homo sapiens (Human)	376	FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). {ECO:0000250|UniProtKB:Q5E9Y9, ECO:0000269|PubMed:36191189}.		CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; phosphorylation [GO:0016310]; UTP biosynthetic process [GO:0006228]	axonemal microtubule [GO:0005879]; centrosome [GO:0005813]; cytosol [GO:0005829]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]	axonemal microtubule [GO:0005879]; centrosome [GO:0005813]; cytosol [GO:0005829]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; phosphorylation [GO:0016310]; UTP biosynthetic process [GO:0006228]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q9Y5B9	reviewed	SP16H_HUMAN	FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16)	SUPT16H FACT140 FACTP140	Homo sapiens (Human)	1047	FUNCTION: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}.		DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]	FACT complex [GO:0035101]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	nucleosome binding [GO:0031491]; RNA binding [GO:0003723]	FACT complex [GO:0035101]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10421373}. Chromosome {ECO:0000269|PubMed:10421373}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Q9Y5C1	reviewed	ANGL3_HUMAN	Angiopoietin-related protein 3 (Angiopoietin-5) (ANG-5) (Angiopoietin-like protein 3) [Cleaved into: ANGPTL3(17-221); ANGPTL3(17-224)]	ANGPTL3 ANGPT5 UNQ153/PRO179	Homo sapiens (Human)	460	FUNCTION: Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed:12909640, PubMed:23661675, PubMed:25495645). Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (By similarity). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1 (PubMed:12097324, PubMed:19318355, PubMed:20581395). Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids (PubMed:17110602, PubMed:19028676). Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906). Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food; the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT (By similarity). Contributes to lower plasma levels of low density lipoprotein (LDL)-cholesterol by a mechanism that is independent of the canonical pathway implicating APOE and LDLR. May stimulate hypothalamic LPL activity (By similarity). {ECO:0000250|UniProtKB:Q9R182, ECO:0000269|PubMed:11788823, ECO:0000269|PubMed:12097324, ECO:0000269|PubMed:12565906, ECO:0000269|PubMed:12909640, ECO:0000269|PubMed:17110602, ECO:0000269|PubMed:19028676, ECO:0000269|PubMed:19318355, ECO:0000269|PubMed:20581395, ECO:0000269|PubMed:23661675, ECO:0000269|PubMed:25495645, ECO:0000305|PubMed:20581395}.; FUNCTION: [ANGPTL3(17-221)]: In vitro inhibits LPL activity; not effective on GPIHBP1-stabilized LPL. {ECO:0000269|PubMed:19542565}.; FUNCTION: Involved in angiogenesis. Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3), activates FAK, MAPK and Akt signaling pathways and induces cell adhesion and cell migration (PubMed:11877390). Secreted from podocytes, may modulate properties of glomerular endothelial cells involving integrin alpha-V/beta-3 and Akt signaling (PubMed:18535744). May increase the motility of podocytes. May induce actin filament rearrangements in podocytes implicating integrin alpha-V/beta-3 and Rac1 activation. Binds to hematopoietic stem cells (HSC) and is involved in the regulation of HSC activity probably implicating down-regulation of IKZF1/IKAROS (By similarity). {ECO:0000250|UniProtKB:Q9R182, ECO:0000269|PubMed:11877390, ECO:0000269|PubMed:18535744}.	MISCELLANEOUS: Was suggested to inhibit LPL through a direct mechanism; however, the necessary concentration to achieve in vitro inhibition is at least 30-fold higher than ANGPTL3 plasma concentration. {ECO:0000305|PubMed:19028676, ECO:0000305|PubMed:20581395}.	acylglycerol homeostasis [GO:0055090]; angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; cell-matrix adhesion [GO:0007160]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; fatty acid metabolic process [GO:0006631]; glycerol metabolic process [GO:0006071]; integrin-mediated signaling pathway [GO:0007229]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; negative regulation of lipoprotein lipase activity [GO:0051005]; negative regulation of phospholipase activity [GO:0010519]; phospholipid catabolic process [GO:0009395]; phospholipid homeostasis [GO:0055091]; phospholipid metabolic process [GO:0006644]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of lipid catabolic process [GO:0050996]; response to hormone [GO:0009725]; signal transduction [GO:0007165]; triglyceride homeostasis [GO:0070328]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; early endosome [GO:0005769]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]	enzyme inhibitor activity [GO:0004857]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; phospholipase inhibitor activity [GO:0004859]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; early endosome [GO:0005769]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; enzyme inhibitor activity [GO:0004857]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; phospholipase inhibitor activity [GO:0004859]; acylglycerol homeostasis [GO:0055090]; angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; cell-matrix adhesion [GO:0007160]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; fatty acid metabolic process [GO:0006631]; glycerol metabolic process [GO:0006071]; integrin-mediated signaling pathway [GO:0007229]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; negative regulation of lipoprotein lipase activity [GO:0051005]; negative regulation of phospholipase activity [GO:0010519]; phospholipid catabolic process [GO:0009395]; phospholipid homeostasis [GO:0055091]; phospholipid metabolic process [GO:0006644]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of lipid catabolic process [GO:0050996]; response to hormone [GO:0009725]; signal transduction [GO:0007165]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Secreted {ECO:0000250, ECO:0000305|PubMed:11877390}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9R182}. Note=Colocalized with HSPG2 and activated ITGB3 on podocytes. {ECO:0000250|UniProtKB:Q9R182}.
Q9Y5E3	reviewed	PCDB6_HUMAN	Protocadherin beta-6 (PCDH-beta-6)	PCDHB6	Homo sapiens (Human)	794	FUNCTION: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain. {ECO:0000250|UniProtKB:Q91XZ4}.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell-cell recognition [GO:0009988]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell-cell recognition [GO:0009988]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q91XZ4}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q91XZ4}.
Q9Y5E9	reviewed	PCDBE_HUMAN	Protocadherin beta-14 (PCDH-beta-14)	PCDHB14	Homo sapiens (Human)	798	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5F1	reviewed	PCDBC_HUMAN	Protocadherin beta-12 (PCDH-beta-12)	PCDHB12	Homo sapiens (Human)	795	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5F2	reviewed	PCDBB_HUMAN	Protocadherin beta-11 (PCDH-beta-11)	PCDHB11	Homo sapiens (Human)	797	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5F7	reviewed	PCDGL_HUMAN	Protocadherin gamma-C4 (PCDH-gamma-C4)	PCDHGC4	Homo sapiens (Human)	938	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]; synapse organization [GO:0050808]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5H5	reviewed	PCDA9_HUMAN	Protocadherin alpha-9 (PCDH-alpha-9)	PCDHA9 KIAA0345	Homo sapiens (Human)	950	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5H8	reviewed	PCDA3_HUMAN	Protocadherin alpha-3 (PCDH-alpha-3)	PCDHA3	Homo sapiens (Human)	950	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5H9	reviewed	PCDA2_HUMAN	Protocadherin alpha-2 (PCDH-alpha-2)	PCDHA2	Homo sapiens (Human)	948	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5I2	reviewed	PCDAA_HUMAN	Protocadherin alpha-10 (PCDH-alpha-10)	PCDHA10 CNRS8	Homo sapiens (Human)	948	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q9Y5I3	reviewed	PCDA1_HUMAN	Protocadherin alpha-1 (PCDH-alpha-1)	PCDHA1	Homo sapiens (Human)	950	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q9Y5I7	reviewed	CLD16_HUMAN	Claudin-16 (Paracellin-1) (PCLN-1)	CLDN16 PCLN1	Homo sapiens (Human)	235	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; intercellular transport [GO:0010496]; intracellular monoatomic cation homeostasis [GO:0030003]; metal ion transport [GO:0030001]	bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; magnesium ion transmembrane transporter activity [GO:0015095]; structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; magnesium ion transmembrane transporter activity [GO:0015095]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; intercellular transport [GO:0010496]; intracellular monoatomic cation homeostasis [GO:0030003]; metal ion transport [GO:0030001]	SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Q9Y5J1	reviewed	UTP18_HUMAN	U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50)	UTP18 WDR50 CDABP0061 CGI-48	Homo sapiens (Human)	556	FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}.		ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:34516797}.
Q9Y5J3	reviewed	HEY1_HUMAN	Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1)	HEY1 BHLHB31 CHF2 HERP2 HESR1 HRT1	Homo sapiens (Human)	304	FUNCTION: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). {ECO:0000250|UniProtKB:Q9WV93, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:25985737}.		angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; arterial endothelial cell differentiation [GO:0060842]; atrioventricular valve formation [GO:0003190]; cardiac conduction system development [GO:0003161]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac septum morphogenesis [GO:0060411]; cardiac ventricle morphogenesis [GO:0003208]; circulatory system development [GO:0072359]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion morphogenesis [GO:0003203]; heart trabecula formation [GO:0060347]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [GO:2000820]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary valve morphogenesis [GO:0003184]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vasculogenesis [GO:2001212]; umbilical cord morphogenesis [GO:0036304]; ventricular septum morphogenesis [GO:0060412]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; arterial endothelial cell differentiation [GO:0060842]; atrioventricular valve formation [GO:0003190]; cardiac conduction system development [GO:0003161]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac septum morphogenesis [GO:0060411]; cardiac ventricle morphogenesis [GO:0003208]; circulatory system development [GO:0072359]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion morphogenesis [GO:0003203]; heart trabecula formation [GO:0060347]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [GO:2000820]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary valve morphogenesis [GO:0003184]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vasculogenesis [GO:2001212]; umbilical cord morphogenesis [GO:0036304]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:26068074}.
Q9Y5J5	reviewed	PHLA3_HUMAN	Pleckstrin homology-like domain family A member 3 (TDAG51/Ipl homolog 1)	PHLDA3 TIH1	Homo sapiens (Human)	127	FUNCTION: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. {ECO:0000269|PubMed:19203586}.	MISCELLANEOUS: PHLDA3 genomic locus is frequently observed in primary lung cancers, suggesting a role in tumor suppression.	anatomical structure morphogenesis [GO:0009653]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; positive regulation of apoptotic process [GO:0043065]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-5-phosphate binding [GO:0010314]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-5-phosphate binding [GO:0010314]; anatomical structure morphogenesis [GO:0009653]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0051898]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19203586}. Membrane {ECO:0000269|PubMed:19203586}; Peripheral membrane protein {ECO:0000269|PubMed:19203586}.
Q9Y5J6	reviewed	T10B_HUMAN	Mitochondrial import inner membrane translocase subunit Tim10 B (Fracture callus protein 1) (FxC1) (Mitochondrial import inner membrane translocase subunit Tim9 B) (TIMM10B) (Tim10b)	TIMM10B FXC1 TIM9B TIMM9B	Homo sapiens (Human)	103	FUNCTION: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}.		cell-matrix adhesion [GO:0007160]; protein insertion into mitochondrial inner membrane [GO:0045039]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]	metal ion binding [GO:0046872]; protein transporter activity [GO:0140318]; unfolded protein binding [GO:0051082]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]; metal ion binding [GO:0046872]; protein transporter activity [GO:0140318]; unfolded protein binding [GO:0051082]; cell-matrix adhesion [GO:0007160]; protein insertion into mitochondrial inner membrane [GO:0045039]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Peripheral membrane protein {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}.
Q9Y5J7	reviewed	TIM9_HUMAN	Mitochondrial import inner membrane translocase subunit Tim9	TIMM9 TIM9 TIM9A TIMM9A	Homo sapiens (Human)	89	FUNCTION: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}.		protein insertion into mitochondrial inner membrane [GO:0045039]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]	membrane insertase activity [GO:0032977]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; zinc ion binding [GO:0008270]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]; membrane insertase activity [GO:0032977]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; zinc ion binding [GO:0008270]; protein insertion into mitochondrial inner membrane [GO:0045039]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Peripheral membrane protein {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Intermembrane side {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}.
Q9Y5K1	reviewed	SPO11_HUMAN	Meiotic recombination protein SPO11 (EC 5.6.2.2) (Cancer/testis antigen 35) (CT35)	SPO11	Homo sapiens (Human)	396	FUNCTION: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2. {ECO:0000250|UniProtKB:Q9WTK8}.		double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; male meiosis I [GO:0007141]; meiotic DNA double-strand break formation [GO:0042138]; meiotic DNA double-strand break processing [GO:0000706]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; ovarian follicle development [GO:0001541]; protein localization to chromosome [GO:0034502]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	chromosome, telomeric region [GO:0000781]; nuclear chromosome [GO:0000228]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; metal ion binding [GO:0046872]	chromosome, telomeric region [GO:0000781]; nuclear chromosome [GO:0000228]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; metal ion binding [GO:0046872]; double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; male meiosis I [GO:0007141]; meiotic DNA double-strand break formation [GO:0042138]; meiotic DNA double-strand break processing [GO:0000706]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; ovarian follicle development [GO:0001541]; protein localization to chromosome [GO:0034502]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9Y5K2	reviewed	KLK4_HUMAN	Kallikrein-4 (EC 3.4.21.-) (Enamel matrix serine proteinase 1) (Kallikrein-like protein 1) (KLK-L1) (Prostase) (Serine protease 17)	KLK4 EMSP1 PRSS17 PSTS	Homo sapiens (Human)	254	FUNCTION: Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity). {ECO:0000250|UniProtKB:Q9Z0M1, ECO:0000269|PubMed:15235027}.		amelogenesis [GO:0097186]; biomineral tissue development [GO:0031214]; extracellular matrix disassembly [GO:0022617]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; secretory granule [GO:0030141]	metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular region [GO:0005576]; secretory granule [GO:0030141]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; amelogenesis [GO:0097186]; biomineral tissue development [GO:0031214]; extracellular matrix disassembly [GO:0022617]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
Q9Y5K3	reviewed	PCY1B_HUMAN	Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B)	PCYT1B CCTB	Homo sapiens (Human)	369	FUNCTION: [Isoform 1]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:9593753}.; FUNCTION: [Isoform 2]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912}.		CDP-choline pathway [GO:0006657]; ovarian follicle development [GO:0001541]; phosphatidylcholine biosynthetic process [GO:0006656]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	choline-phosphate cytidylyltransferase activity [GO:0004105]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; choline-phosphate cytidylyltransferase activity [GO:0004105]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]; CDP-choline pathway [GO:0006657]; ovarian follicle development [GO:0001541]; phosphatidylcholine biosynthetic process [GO:0006656]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:9593753}. Endoplasmic reticulum {ECO:0000269|PubMed:10480912}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum {ECO:0000269|PubMed:10480912}.
Q9Y5K5	reviewed	UCHL5_HUMAN	Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)	UCHL5 UCH37 AD-019 CGI-70	Homo sapiens (Human)	329	FUNCTION: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. {ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:18922472}.		chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; forebrain morphogenesis [GO:0048853]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; protein deubiquitination [GO:0016579]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of proteasomal protein catabolic process [GO:0061136]; telomere maintenance [GO:0000723]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; Ino80 complex [GO:0031011]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; Ino80 complex [GO:0031011]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; RNA binding [GO:0003723]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; forebrain morphogenesis [GO:0048853]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; protein deubiquitination [GO:0016579]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of proteasomal protein catabolic process [GO:0061136]; telomere maintenance [GO:0000723]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18922472}. Nucleus {ECO:0000269|PubMed:18922472}. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus.
Q9Y5K6	reviewed	CD2AP_HUMAN	CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)	CD2AP	Homo sapiens (Human)	639	FUNCTION: Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}.		actin filament organization [GO:0007015]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell migration [GO:0016477]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of transforming growth factor beta1 production [GO:0032911]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein secretion [GO:0050714]; protein-containing complex assembly [GO:0065003]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]; synapse organization [GO:0050808]; transforming growth factor beta1 production [GO:0032905]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; filamentous actin [GO:0031941]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; vesicle [GO:0031982]	cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; filamentous actin [GO:0031941]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; structural constituent of cytoskeleton [GO:0005200]; actin filament organization [GO:0007015]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell migration [GO:0016477]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of transforming growth factor beta1 production [GO:0032911]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein secretion [GO:0050714]; protein-containing complex assembly [GO:0065003]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]; synapse organization [GO:0050808]; transforming growth factor beta1 production [GO:0032905]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15800069}. Cell projection, ruffle {ECO:0000269|PubMed:10339567}. Cell junction {ECO:0000269|PubMed:22891260}. Note=Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles (PubMed:10339567). Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase (PubMed:15800069). {ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069}.
Q9Y5K8	reviewed	VATD_HUMAN	V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D)	ATP6V1D ATP6M VATD	Homo sapiens (Human)	247	FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (PubMed:21844891). {ECO:0000250|UniProtKB:P39942, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:33065002}.		cilium assembly [GO:0060271]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; protein localization to cilium [GO:0061512]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	cilium [GO:0005929]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; specific granule membrane [GO:0035579]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	proton-transporting ATPase activity, rotational mechanism [GO:0046961]	cilium [GO:0005929]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; specific granule membrane [GO:0035579]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; cilium assembly [GO:0060271]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; protein localization to cilium [GO:0061512]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:21844891}; Peripheral membrane protein {ECO:0000305|PubMed:21844891}; Cytoplasmic side {ECO:0000305|PubMed:21844891}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P39942}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21844891}. Cell projection, cilium {ECO:0000269|PubMed:21844891}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000269|PubMed:21844891}.
Q9Y5L0	reviewed	TNPO3_HUMAN	Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)	TNPO3 IPO12	Homo sapiens (Human)	923	FUNCTION: Importin, which transports target proteins into the nucleus (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation (PubMed:30916345, PubMed:31465518). The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively (PubMed:23878195, PubMed:24449914). Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus (PubMed:23878195, PubMed:24449914). {ECO:0000269|PubMed:10366588, ECO:0000269|PubMed:10713112, ECO:0000269|PubMed:11517331, ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:23878195, ECO:0000269|PubMed:24449914, ECO:0000269|PubMed:30916345, ECO:0000269|PubMed:31465518}.; FUNCTION: (Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus (PubMed:18722123, PubMed:21901095, PubMed:22398280, PubMed:29329553). Required for a nuclear maturation step of HIV-1 prior to integration (PubMed:21901095, PubMed:22398280). {ECO:0000269|PubMed:18722123, ECO:0000269|PubMed:21901095, ECO:0000269|PubMed:22398280, ECO:0000269|PubMed:29329553}.		protein import into nucleus [GO:0006606]	annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]	identical protein binding [GO:0042802]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267]	annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; identical protein binding [GO:0042802]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:31192305, ECO:0000305|PubMed:10713112, ECO:0000305|PubMed:23543484}. Cytoplasm {ECO:0000269|PubMed:10713112}. Note=Localizes to the nuclear envelope and annulate lamellae, which consists in stacks of endoplasmic reticulum membranes containing a high density of nuclear pores. {ECO:0000269|PubMed:31192305}.
Q9Y5L2	reviewed	HLPDA_HUMAN	Hypoxia-inducible lipid droplet-associated protein (Hypoxia-inducible gene 2 protein)	HILPDA C7orf68 HIG2	Homo sapiens (Human)	63	FUNCTION: Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation. {ECO:0000269|PubMed:15930302, ECO:0000269|PubMed:20624928}.		autocrine signaling [GO:0035425]; cellular response to hypoxia [GO:0071456]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of lipid storage [GO:0010884]	cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular space [GO:0005615]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; secretory granule [GO:0030141]	signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular space [GO:0005615]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; secretory granule [GO:0030141]; signaling receptor binding [GO:0005102]; autocrine signaling [GO:0035425]; cellular response to hypoxia [GO:0071456]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of lipid storage [GO:0010884]	SUBCELLULAR LOCATION: Lipid droplet. Secreted. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9Y5L3	reviewed	ENTP2_HUMAN	Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase 2) (EC 3.6.1.-) (CD39 antigen-like 1) (Ecto-ATP diphosphohydrolase 2) (Ecto-ATPDase 2) (Ecto-ATPase 2)	ENTPD2 CD39L1	Homo sapiens (Human)	495	FUNCTION: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.	MISCELLANEOUS: [Isoform Short]: Catalytically inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform gamma]: Catalytically inactive. {ECO:0000305}.	G protein-coupled receptor signaling pathway [GO:0007186]; nucleoside diphosphate catabolic process [GO:0009134]; platelet activation [GO:0030168]; purine ribonucleoside diphosphate catabolic process [GO:0009181]	basement membrane [GO:0005604]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]	basement membrane [GO:0005604]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]; G protein-coupled receptor signaling pathway [GO:0007186]; nucleoside diphosphate catabolic process [GO:0009134]; platelet activation [GO:0030168]; purine ribonucleoside diphosphate catabolic process [GO:0009181]	SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane; Multi-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform Short]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform gamma]: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Q9Y5L4	reviewed	TIM13_HUMAN	Mitochondrial import inner membrane translocase subunit Tim13	TIMM13 TIM13B TIMM13A TIMM13B	Homo sapiens (Human)	95	FUNCTION: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}.		protein insertion into mitochondrial inner membrane [GO:0045039]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605]	fibrillar center [GO:0001650]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; mitochondrion [GO:0005739]	zinc ion binding [GO:0008270]	fibrillar center [GO:0001650]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; mitochondrion [GO:0005739]; zinc ion binding [GO:0008270]; protein insertion into mitochondrial inner membrane [GO:0045039]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11489896}; Peripheral membrane protein {ECO:0000269|PubMed:11489896}; Intermembrane side {ECO:0000269|PubMed:11489896}.
Q9Y5N1	reviewed	HRH3_HUMAN	Histamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97)	HRH3 GPCR97	Homo sapiens (Human)	445	FUNCTION: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.	MISCELLANEOUS: Does not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit, N-alpha-methylhistamine and R(-)-alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while isoforms 1 and 3 bind it with high affinity.	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of serotonin secretion [GO:0014063]; neurotransmitter secretion [GO:0007269]; regulation of norepinephrine secretion [GO:0014061]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synapse [GO:0045202]	G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synapse [GO:0045202]; G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of serotonin secretion [GO:0014063]; neurotransmitter secretion [GO:0007269]; regulation of norepinephrine secretion [GO:0014061]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9Y5N5	reviewed	N6MT1_HUMAN	Methyltransferase N6AMT1 (HemK methyltransferase family member 2) (M.HsaHemK2P) (Lysine N-methyltransferase 9) (EC 2.1.1.-) (Methylarsonite methyltransferase N6AMT1) (EC 2.1.1.-) (Protein N(5)-glutamine methyltransferase) (EC 2.1.1.-)	N6AMT1 C21orf127 HEMK2 KMT9 PRED28	Homo sapiens (Human)	214	FUNCTION: Methyltransferase that can methylate proteins and, to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583, PubMed:31636962, PubMed:31061526). Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators (PubMed:31061526). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146, PubMed:31632689, PubMed:31636962). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008, PubMed:31636962, PubMed:31061526). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655). {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:20606008, ECO:0000269|PubMed:21193388, ECO:0000269|PubMed:25997655, ECO:0000269|PubMed:30017583, ECO:0000269|PubMed:31061526, ECO:0000269|PubMed:31632689, ECO:0000269|PubMed:31636962}.		arsonoacetate metabolic process [GO:0018872]; DNA methylation on adenine [GO:0032775]; methylation [GO:0032259]; peptidyl-glutamine methylation [GO:0018364]; positive regulation of cell growth [GO:0030307]; toxin metabolic process [GO:0009404]; transcription initiation-coupled chromatin remodeling [GO:0045815]	cytosol [GO:0005829]; eRF1 methyltransferase complex [GO:0035657]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	histone H4K12 methyltransferase activity [GO:0140984]; methylarsonite methyltransferase activity [GO:0030792]; nucleic acid binding [GO:0003676]; protein methyltransferase activity [GO:0008276]; protein-glutamine N-methyltransferase activity [GO:0036009]; S-adenosyl-L-methionine binding [GO:1904047]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007]	cytosol [GO:0005829]; eRF1 methyltransferase complex [GO:0035657]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; histone H4K12 methyltransferase activity [GO:0140984]; methylarsonite methyltransferase activity [GO:0030792]; nucleic acid binding [GO:0003676]; protein methyltransferase activity [GO:0008276]; protein-glutamine N-methyltransferase activity [GO:0036009]; S-adenosyl-L-methionine binding [GO:1904047]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007]; arsonoacetate metabolic process [GO:0018872]; DNA methylation on adenine [GO:0032775]; methylation [GO:0032259]; peptidyl-glutamine methylation [GO:0018364]; positive regulation of cell growth [GO:0030307]; toxin metabolic process [GO:0009404]; transcription initiation-coupled chromatin remodeling [GO:0045815]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6SKR2}.
Q9Y5N6	reviewed	ORC6_HUMAN	Origin recognition complex subunit 6	ORC6 ORC6L	Homo sapiens (Human)	252	FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655}.		DNA replication initiation [GO:0006270]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]	DNA binding [GO:0003677]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]; DNA binding [GO:0003677]; DNA replication initiation [GO:0006270]	SUBCELLULAR LOCATION: Nucleus.
Q9Y5P4	reviewed	CERT_HUMAN	Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11)	CERT1 CERT COL4A3BP STARD11	Homo sapiens (Human)	624	FUNCTION: Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}.		cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; ceramide metabolic process [GO:0006672]; ceramide transport [GO:0035627]; endoplasmic reticulum organization [GO:0007029]; ER to Golgi ceramide transport [GO:0035621]; heart morphogenesis [GO:0003007]; immune response [GO:0006955]; in utero embryonic development [GO:0001701]; intermembrane lipid transfer [GO:0120009]; intermembrane sphingolipid transfer [GO:0120012]; lipid homeostasis [GO:0055088]; mitochondrion morphogenesis [GO:0070584]; muscle contraction [GO:0006936]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ceramide binding [GO:0097001]; ceramide transfer activity [GO:0120017]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; phosphatidylinositol-4-phosphate binding [GO:0070273]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ceramide binding [GO:0097001]; ceramide transfer activity [GO:0120017]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; phosphatidylinositol-4-phosphate binding [GO:0070273]; cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; ceramide metabolic process [GO:0006672]; ceramide transport [GO:0035627]; endoplasmic reticulum organization [GO:0007029]; ER to Golgi ceramide transport [GO:0035621]; heart morphogenesis [GO:0003007]; immune response [GO:0006955]; in utero embryonic development [GO:0001701]; intermembrane lipid transfer [GO:0120009]; intermembrane sphingolipid transfer [GO:0120012]; lipid homeostasis [GO:0055088]; mitochondrion morphogenesis [GO:0070584]; muscle contraction [GO:0006936]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16895911, ECO:0000269|PubMed:18184806}. Golgi apparatus {ECO:0000269|PubMed:16895911, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:29858488}. Endoplasmic reticulum {ECO:0000269|PubMed:16895911, ECO:0000269|PubMed:18184806}. Note=Preferentially localized to the Golgi apparatus. {ECO:0000305|PubMed:16895911}.
Q9Y5P6	reviewed	GMPPB_HUMAN	Mannose-1-phosphate guanyltransferase beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta)	GMPPB	Homo sapiens (Human)	360	FUNCTION: Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. {ECO:0000250|UniProtKB:P0C5I2}.		GDP-mannose biosynthetic process [GO:0009298]; protein glycosylation [GO:0006486]	cytoplasm [GO:0005737]	GTP binding [GO:0005525]; mannose-1-phosphate guanylyltransferase (GTP) activity [GO:0004475]	cytoplasm [GO:0005737]; GTP binding [GO:0005525]; mannose-1-phosphate guanylyltransferase (GTP) activity [GO:0004475]; GDP-mannose biosynthetic process [GO:0009298]; protein glycosylation [GO:0006486]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23768512}.
Q9Y5P8	reviewed	P2R3B_HUMAN	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (PP2A subunit B isoform PR48) (Protein phosphatase 2A 48 kDa regulatory subunit)	PPP2R3B PPP2R3L	Homo sapiens (Human)	575	FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.	protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	calcium ion binding [GO:0005509]; protein phosphatase regulator activity [GO:0019888]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]; calcium ion binding [GO:0005509]; protein phosphatase regulator activity [GO:0019888]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10629059}.
Q9Y5Q0	reviewed	FADS3_HUMAN	Fatty acid desaturase 3 (FADS3) (EC 1.14.19.-) (Delta(13) fatty acid desaturase) (Delta(13) desaturase)	FADS3 CYB5RP	Homo sapiens (Human)	445	FUNCTION: Mammals have different sphingoid bases that differ in their length and/or pattern of desaturation and hydroxyl groups. The predominant sphingoid base that comprises mammalian ceramides is sphing-4-enine (sphingosine or SPH) which has a trans (E) desaturation at carbon 4 (PubMed:31916624, PubMed:31862735). FADS3 is a desaturase that introduces a cis (Z) double bond between carbon 14 and carbon 15 of the sphingoid base (also known as long chain base, LCB), producing LCBs such as sphinga-4,14-dienine (SPD, d18:2(4E,14Z)) from SPH (PubMed:31916624, PubMed:31862735, PubMed:37209771). Prefers SPH-containing ceramides (N-acylsphing-4-enines) as substrates (PubMed:31916624, PubMed:31862735, PubMed:37209771). Capable of metabolizing also the SPH in its free form (PubMed:31862735). SPD ceramides occur widely in mammalian tissues and cells (PubMed:31916624). Due to their unusual structure containing a cis double bond, SPD ceramides may have an opposite, negative role in lipid microdomain formation relative to conventional ceramides (PubMed:31916624). Could be involved in the detoxification of 1-deoxy sphingolipids, by desaturating the cytotoxic 1-deoxysphinganine (1-deoxySA, m18:0), produced under pathological conditions, to 1-deoxysphingenine (1-deoxysphingosine, 1-deoxySO, m18:1) (Probable). Although prefers SPH-containing ceramides (N-acylsphing-4-enines) as substrates, it also exhibits activity toward dihydrosphingosine-containing CERs (N-acylsphinganines) and produces 14Z-SPH-containing sphingolipids,which can be found in patients with DEGS1 mutations (PubMed:37209771). Its desaturase mechanism involves an electron transfer facilitated by cytochrome b5 (PubMed:37209771). FADS3 also acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain (By similarity). Desaturates (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 13 to generate (11E,13Z)-octadecadienoate (also known as conjugated linoleic acid 11E,13Z-CLA) (By similarity). {ECO:0000250|UniProtKB:Q8K1P9, ECO:0000269|PubMed:31862735, ECO:0000269|PubMed:31916624, ECO:0000269|PubMed:37209771, ECO:0000305|PubMed:31862735}.	MISCELLANEOUS: A 28 kDa isoform is expressed in lung, kidney, pancreas and ovary (at protein level). {ECO:0000269|PubMed:19752397}.	lipid metabolic process [GO:0006629]; sphingolipid metabolic process [GO:0006665]; unsaturated fatty acid biosynthetic process [GO:0006636]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]; lipid metabolic process [GO:0006629]; sphingolipid metabolic process [GO:0006665]; unsaturated fatty acid biosynthetic process [GO:0006636]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:31916624}; Multi-pass membrane protein {ECO:0000255}.
Q9Y5Q3	reviewed	MAFB_HUMAN	Transcription factor MafB (Maf-B) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B)	MAFB KRML	Homo sapiens (Human)	323	FUNCTION: Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). {ECO:0000250|UniProtKB:P54841, ECO:0000269|PubMed:19143053, ECO:0000269|PubMed:27181683}.		abducens nerve formation [GO:0021599]; brain segmentation [GO:0035284]; cornified envelope assembly [GO:1903575]; fat cell differentiation [GO:0045444]; inner ear morphogenesis [GO:0042472]; integrated stress response signaling [GO:0140467]; keratinocyte differentiation [GO:0030216]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; protein processing [GO:0016485]; regulation of DNA-templated transcription [GO:0006355]; regulation of myeloid cell differentiation [GO:0045637]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory gaseous exchange by respiratory system [GO:0007585]; rhombomere 5 development [GO:0021571]; rhombomere 6 development [GO:0021572]; segment specification [GO:0007379]; sensory organ development [GO:0007423]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; abducens nerve formation [GO:0021599]; brain segmentation [GO:0035284]; cornified envelope assembly [GO:1903575]; fat cell differentiation [GO:0045444]; inner ear morphogenesis [GO:0042472]; integrated stress response signaling [GO:0140467]; keratinocyte differentiation [GO:0030216]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; protein processing [GO:0016485]; regulation of DNA-templated transcription [GO:0006355]; regulation of myeloid cell differentiation [GO:0045637]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory gaseous exchange by respiratory system [GO:0007585]; rhombomere 5 development [GO:0021571]; rhombomere 6 development [GO:0021572]; segment specification [GO:0007379]; sensory organ development [GO:0007423]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Q9Y5Q5	reviewed	CORIN_HUMAN	Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]	CORIN CRN TMPRSS10	Homo sapiens (Human)	1042	FUNCTION: Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity). {ECO:0000250|UniProtKB:Q9Z319, ECO:0000269|PubMed:10880574, ECO:0000269|PubMed:20489134, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:21763278, ECO:0000269|PubMed:22437503}.; FUNCTION: [Isoform 2]: Has weaker endopeptidase activity compared to isoform 1.	MISCELLANEOUS: Initially named CORIN due to its abundant expression in the heart. {ECO:0000305|PubMed:10329693}.	female pregnancy [GO:0007565]; peptide hormone processing [GO:0016486]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of renal sodium excretion [GO:0035813]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050]	actin cytoskeleton [GO:0015629]; cell surface [GO:0009986]; extracellular region [GO:0005576]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]	endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252]	actin cytoskeleton [GO:0015629]; cell surface [GO:0009986]; extracellular region [GO:0005576]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252]; female pregnancy [GO:0007565]; peptide hormone processing [GO:0016486]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of renal sodium excretion [GO:0035813]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19751717, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:21518754}; Single-pass type II membrane protein {ECO:0000269|PubMed:19751717, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:21518754}. Note=May easily detached from the endothelial cell membrane.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1.; SUBCELLULAR LOCATION: [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted. Note=Soluble form produced following cleavage by ADAM10.; SUBCELLULAR LOCATION: [Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment]: Secreted. Note=Soluble form produced following autocatalytic cleavage.; SUBCELLULAR LOCATION: [Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]: Secreted. Note=Soluble form produced following autocatalytic cleavage.
Q9Y5Q6	reviewed	INSL5_HUMAN	Insulin-like peptide INSL5 (Insulin-like peptide 5) [Cleaved into: Insulin-like peptide INSL5 B chain; Insulin-like peptide INSL5 A chain]	INSL5 UNQ156/PRO182	Homo sapiens (Human)	135	FUNCTION: May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.		positive regulation of feeding behavior [GO:2000253]	extracellular region [GO:0005576]	G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]	extracellular region [GO:0005576]; G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; positive regulation of feeding behavior [GO:2000253]	SUBCELLULAR LOCATION: Secreted.
Q9Y5Q8	reviewed	TF3C5_HUMAN	General transcription factor 3C polypeptide 5 (TF3C-epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon)	GTF3C5 CDABP0017	Homo sapiens (Human)	519	FUNCTION: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.		5S class rRNA transcription by RNA polymerase III [GO:0042791]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription by RNA polymerase III [GO:0042797]	nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]	DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995]	nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]; DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; 5S class rRNA transcription by RNA polymerase III [GO:0042791]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription by RNA polymerase III [GO:0042797]	SUBCELLULAR LOCATION: Nucleus.
Q9Y5Q9	reviewed	TF3C3_HUMAN	General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma)	GTF3C3	Homo sapiens (Human)	886	FUNCTION: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.	MISCELLANEOUS: [Isoform 2]: May be due to exon skipping. {ECO:0000305}.	5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; tRNA transcription by RNA polymerase III [GO:0042797]	fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]	DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995]	fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]; DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; 5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; tRNA transcription by RNA polymerase III [GO:0042797]	SUBCELLULAR LOCATION: Nucleus.
Q9Y5R2	reviewed	MMP24_HUMAN	Matrix metalloproteinase-24 (MMP-24) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (MTMMP5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MT5MMP) [Cleaved into: Processed matrix metalloproteinase-24]	MMP24 MT5MMP	Homo sapiens (Human)	645	FUNCTION: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). {ECO:0000250}.		cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; collagen catabolic process [GO:0030574]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; extracellular matrix organization [GO:0030198]; glial cell differentiation [GO:0010001]; neuronal stem cell population maintenance [GO:0097150]; proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	cadherin binding [GO:0045296]; enzyme activator activity [GO:0008047]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; cadherin binding [GO:0045296]; enzyme activator activity [GO:0008047]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; collagen catabolic process [GO:0030574]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; extracellular matrix organization [GO:0030198]; glial cell differentiation [GO:0010001]; neuronal stem cell population maintenance [GO:0097150]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: [Matrix metalloproteinase-24]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. {ECO:0000250}.; SUBCELLULAR LOCATION: [Processed matrix metalloproteinase-24]: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage. {ECO:0000250}.
Q9Y5R4	reviewed	HEMK1_HUMAN	MTRF1L release factor glutamine methyltransferase (EC 2.1.1.297) (HemK methyltransferase family member 1) (M.HsaHemKP)	HEMK1 HEMK	Homo sapiens (Human)	338	FUNCTION: N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factors MTRF1, MTRF1L, MRPL58/ICT1 and MTRFR. {ECO:0000269|PubMed:18541145, ECO:0000269|PubMed:35260756}.		DNA methylation [GO:0006306]; protein metabolic process [GO:0019538]	mitochondrion [GO:0005739]	DNA binding [GO:0003677]; N-methyltransferase activity [GO:0008170]; protein methyltransferase activity [GO:0008276]; protein-(glutamine-N5) methyltransferase activity [GO:0102559]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	mitochondrion [GO:0005739]; DNA binding [GO:0003677]; N-methyltransferase activity [GO:0008170]; protein methyltransferase activity [GO:0008276]; protein-(glutamine-N5) methyltransferase activity [GO:0102559]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; DNA methylation [GO:0006306]; protein metabolic process [GO:0019538]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18541145}.
Q9Y5R5	reviewed	DMRT2_HUMAN	Doublesex- and mab-3-related transcription factor 2 (Doublesex-like 2 protein) (DSXL-2)	DMRT2 DSXL2	Homo sapiens (Human)	561	FUNCTION: Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: Produced by DMRT2 bicistronic transcripts (AF284223/AF284224) from non-overlapping reading frame, according to PubMed:10729224. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by DMRT2 bicistronic transcripts (AF284223/AF284224) from non-overlapping reading frame, according to PubMed:10729224. {ECO:0000305}.	embryonic skeletal system development [GO:0048706]; myotome development [GO:0061055]; positive regulation of myotome development [GO:2000287]; regulation of somitogenesis [GO:0014807]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; embryonic skeletal system development [GO:0048706]; myotome development [GO:0061055]; positive regulation of myotome development [GO:2000287]; regulation of somitogenesis [GO:0014807]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Q9Y5R6	reviewed	DMRT1_HUMAN	Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1)	DMRT1 DMT1	Homo sapiens (Human)	373	FUNCTION: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). {ECO:0000250}.		cell morphogenesis [GO:0000902]; germ cell migration [GO:0008354]; intracellular signal transduction [GO:0035556]; male germ cell proliferation [GO:0002176]; male sex determination [GO:0030238]; male sex differentiation [GO:0046661]; meiosis I [GO:0007127]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte development [GO:0048599]; positive regulation of male gonad development [GO:2000020]; positive regulation of meiosis I [GO:0060903]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of nodal signaling pathway [GO:1900107]; regulation of transcription by RNA polymerase II [GO:0006357]; Sertoli cell development [GO:0060009]; Sertoli cell differentiation [GO:0060008]; sex differentiation [GO:0007548]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell morphogenesis [GO:0000902]; germ cell migration [GO:0008354]; intracellular signal transduction [GO:0035556]; male germ cell proliferation [GO:0002176]; male sex determination [GO:0030238]; male sex differentiation [GO:0046661]; meiosis I [GO:0007127]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte development [GO:0048599]; positive regulation of male gonad development [GO:2000020]; positive regulation of meiosis I [GO:0060903]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of nodal signaling pathway [GO:1900107]; regulation of transcription by RNA polymerase II [GO:0006357]; Sertoli cell development [GO:0060009]; Sertoli cell differentiation [GO:0060008]; sex differentiation [GO:0007548]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Q9Y5R8	reviewed	TPPC1_HUMAN	Trafficking protein particle complex subunit 1 (BET5 homolog) (Multiple myeloma protein 2) (MUM-2)	TRAPPC1 BET5 MUM2	Homo sapiens (Human)	145	FUNCTION: May play a role in vesicular transport from endoplasmic reticulum to Golgi.		COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]		azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Q9Y5S1	reviewed	TRPV2_HUMAN	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1)	TRPV2 VRL	Homo sapiens (Human)	764	FUNCTION: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. {ECO:0000269|PubMed:10201375}.		calcium ion transmembrane transport [GO:0070588]; positive regulation of axon extension [GO:0045773]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to temperature stimulus [GO:0009266]; sensory perception [GO:0007600]	axonal growth cone [GO:0044295]; cell body [GO:0044297]; cell surface [GO:0009986]; growth cone membrane [GO:0032584]; melanosome [GO:0042470]; plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]; monoatomic cation channel activity [GO:0005261]; monoatomic ion channel activity [GO:0005216]; monoatomic ion transmembrane transporter activity [GO:0015075]	axonal growth cone [GO:0044295]; cell body [GO:0044297]; cell surface [GO:0009986]; growth cone membrane [GO:0032584]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; monoatomic cation channel activity [GO:0005261]; monoatomic ion channel activity [GO:0005216]; monoatomic ion transmembrane transporter activity [GO:0015075]; calcium ion transmembrane transport [GO:0070588]; positive regulation of axon extension [GO:0045773]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to temperature stimulus [GO:0009266]; sensory perception [GO:0007600]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.
Q9Y5S2	reviewed	MRCKB_HUMAN	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)	CDC42BPB KIAA1124	Homo sapiens (Human)	1711	FUNCTION: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.		actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; establishment or maintenance of cell polarity [GO:0007163]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	actomyosin [GO:0042641]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]	actomyosin [GO:0042641]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; establishment or maintenance of cell polarity [GO:0007163]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:21240187}; Peripheral membrane protein {ECO:0000269|PubMed:21240187}; Cytoplasmic side {ECO:0000269|PubMed:21240187}. Cell junction {ECO:0000269|PubMed:21240187}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q3UU96}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42 (PubMed:21240187). Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner (By similarity). {ECO:0000250|UniProtKB:O54874, ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:21240187}.
Q9Y5S8	reviewed	NOX1_HUMAN	NADPH oxidase 1 (NOX-1) (EC 1.-.-.-) (Mitogenic oxidase 1) (MOX-1) (NADH/NADPH mitogenic oxidase subunit P65-MOX) (NOH-1)	NOX1 MOX1 NOH1	Homo sapiens (Human)	564	FUNCTION: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.		angiogenesis [GO:0001525]; cell migration [GO:0016477]; cellular response to hyperoxia [GO:0071455]; cellular stress response to acidic pH [GO:1990451]; defense response [GO:0006952]; extracellular matrix organization [GO:0030198]; hydrogen peroxide metabolic process [GO:0042743]; inflammatory response [GO:0006954]; intracellular pH elevation [GO:0051454]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; JNK cascade [GO:0007254]; NADP metabolic process [GO:0006739]; oxygen metabolic process [GO:0072592]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of JNK cascade [GO:0046330]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of blood pressure [GO:0008217]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; respiratory burst [GO:0045730]; signal transduction [GO:0007165]; superoxide anion generation [GO:0042554]	anchoring junction [GO:0070161]; cell projection [GO:0042995]; early endosome [GO:0005769]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; NADP binding [GO:0050661]; small GTPase binding [GO:0031267]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; voltage-gated monoatomic ion channel activity [GO:0005244]	anchoring junction [GO:0070161]; cell projection [GO:0042995]; early endosome [GO:0005769]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; small GTPase binding [GO:0031267]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; voltage-gated monoatomic ion channel activity [GO:0005244]; angiogenesis [GO:0001525]; cell migration [GO:0016477]; cellular response to hyperoxia [GO:0071455]; cellular stress response to acidic pH [GO:1990451]; defense response [GO:0006952]; extracellular matrix organization [GO:0030198]; hydrogen peroxide metabolic process [GO:0042743]; inflammatory response [GO:0006954]; intracellular pH elevation [GO:0051454]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; JNK cascade [GO:0007254]; NADP metabolic process [GO:0006739]; oxygen metabolic process [GO:0072592]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of JNK cascade [GO:0046330]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of blood pressure [GO:0008217]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; respiratory burst [GO:0045730]; signal transduction [GO:0007165]; superoxide anion generation [GO:0042554]	SUBCELLULAR LOCATION: Cell projection, invadopodium membrane {ECO:0000269|PubMed:19755710}; Multi-pass membrane protein {ECO:0000269|PubMed:19755710}. Cell membrane {ECO:0000269|PubMed:26301257}.
Q9Y5S9	reviewed	RBM8A_HUMAN	RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A)	RBM8A RBM8 HSPC114 MDS014	Homo sapiens (Human)	174	FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. The MAGOH-RBM8A heterodimer is a component of the nonsense mediated decay (NMD) pathway. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. {ECO:0000269|PubMed:12121612, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:12730685, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:19409878, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}.		mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA processing [GO:0050684]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; exon-exon junction subcomplex mago-y14 [GO:1990501]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; exon-exon junction subcomplex mago-y14 [GO:1990501]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA processing [GO:0050684]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11030346, ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. Nucleus speckle {ECO:0000269|PubMed:11030346, ECO:0000269|PubMed:19324961}. Cytoplasm {ECO:0000269|PubMed:11030346, ECO:0000269|PubMed:19324961}. Note=Nucleocytoplasmic shuttling protein (PubMed:11030346). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles (PubMed:19324961). {ECO:0000269|PubMed:11030346, ECO:0000269|PubMed:19324961}.
Q9Y5T4	reviewed	DJC15_HUMAN	DnaJ homolog subfamily C member 15 (Cell growth-inhibiting gene 22 protein) (Methylation-controlled J protein) (MCJ)	DNAJC15 DNAJD1 GIG22 HSD18	Homo sapiens (Human)	150	FUNCTION: Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. {ECO:0000250, ECO:0000269|PubMed:23263864}.		cellular response to starvation [GO:0009267]; intracellular protein transport [GO:0006886]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; negative regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902957]; negative regulation of protein-containing complex assembly [GO:0031333]; protein import into mitochondrial matrix [GO:0030150]; protein-containing complex assembly [GO:0065003]; regulation of lipid metabolic process [GO:0019216]	mitochondrial inner membrane [GO:0005743]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	ATPase activator activity [GO:0001671]	mitochondrial inner membrane [GO:0005743]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; ATPase activator activity [GO:0001671]; cellular response to starvation [GO:0009267]; intracellular protein transport [GO:0006886]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; negative regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902957]; negative regulation of protein-containing complex assembly [GO:0031333]; protein import into mitochondrial matrix [GO:0030150]; protein-containing complex assembly [GO:0065003]; regulation of lipid metabolic process [GO:0019216]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:23263864, ECO:0000269|PubMed:23530063}; Single-pass membrane protein {ECO:0000269|PubMed:23263864, ECO:0000269|PubMed:23530063}.
Q9Y5T5	reviewed	UBP16_HUMAN	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16)	USP16 MSTP039	Homo sapiens (Human)	823	FUNCTION: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). {ECO:0000255|HAMAP-Rule:MF_03062, ECO:0000269|PubMed:17914355, ECO:0000269|PubMed:32129764}.	MISCELLANEOUS: USP16 may contribute to somatic stem cell defects observed in Down syndrome. USP16 is triplicated in Down syndrome and its overexpression may contribute to proliferation defects in stem cells. Reduction of USP16 levels results in increased proliferation capacity of Down syndrome fibroblasts (PubMed:24025767). {ECO:0000305|PubMed:24025767}.	cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic nuclear division [GO:0140014]; monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ribosome biogenesis [GO:0090070]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational elongation [GO:0045901]; protein homotetramerization [GO:0051289]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; ribosomal small subunit binding [GO:0043024]; transcription coactivator activity [GO:0003713]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; ribosomal small subunit binding [GO:0043024]; transcription coactivator activity [GO:0003713]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]; cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic nuclear division [GO:0140014]; monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ribosome biogenesis [GO:0090070]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational elongation [GO:0045901]; protein homotetramerization [GO:0051289]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:17914355}. Cytoplasm {ECO:0000269|PubMed:32129764}.
Q9Y5U2	reviewed	TSSC4_HUMAN	U5 small nuclear ribonucleoprotein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein)	TSSC4	Homo sapiens (Human)	329	FUNCTION: Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus (PubMed:34131137, PubMed:35188580). Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing (PubMed:35188580). Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP (PubMed:34131137). {ECO:0000269|PubMed:34131137, ECO:0000269|PubMed:35188580}.		spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U5 snRNP [GO:0005682]	molecular sequestering activity [GO:0140313]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U5 snRNP [GO:0005682]; molecular sequestering activity [GO:0140313]; protein-containing complex binding [GO:0044877]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34131137}. Cytoplasm {ECO:0000269|PubMed:34131137}. Note=Shuttles between the cytoplasm and the nucleus, associated with the U5 snRNP. {ECO:0000269|PubMed:34131137}.
Q9Y5U4	reviewed	INSI2_HUMAN	Insulin-induced gene 2 protein (INSIG-2)	INSIG2	Homo sapiens (Human)	225	FUNCTION: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:26160948, PubMed:17428920, PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 (PubMed:16606821, PubMed:22143767). {ECO:0000269|PubMed:12242332, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:17428920, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26160948, ECO:0000269|PubMed:32322062}.		cellular response to insulin stimulus [GO:0032869]; cholesterol biosynthetic process [GO:0006695]; cranial suture morphogenesis [GO:0060363]; inner ear morphogenesis [GO:0042472]; middle ear morphogenesis [GO:0042474]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of steroid biosynthetic process [GO:0010894]; roof of mouth development [GO:0060021]; SREBP signaling pathway [GO:0032933]; SREBP-SCAP complex retention in endoplasmic reticulum [GO:0036316]; triglyceride metabolic process [GO:0006641]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SREBP-SCAP-Insig complex [GO:0032937]	oxysterol binding [GO:0008142]; protein sequestering activity [GO:0140311]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SREBP-SCAP-Insig complex [GO:0032937]; oxysterol binding [GO:0008142]; protein sequestering activity [GO:0140311]; cellular response to insulin stimulus [GO:0032869]; cholesterol biosynthetic process [GO:0006695]; cranial suture morphogenesis [GO:0060363]; inner ear morphogenesis [GO:0042472]; middle ear morphogenesis [GO:0042474]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of steroid biosynthetic process [GO:0010894]; roof of mouth development [GO:0060021]; SREBP signaling pathway [GO:0032933]; SREBP-SCAP complex retention in endoplasmic reticulum [GO:0036316]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12242332, ECO:0000269|PubMed:32322062}; Multi-pass membrane protein {ECO:0000269|PubMed:12242332}.
Q9Y5U5	reviewed	TNR18_HUMAN	Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357)	TNFRSF18 AITR GITR UNQ319/PRO364	Homo sapiens (Human)	241	FUNCTION: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell adhesion [GO:0045785]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; signal transduction [GO:0007165]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	tumor necrosis factor receptor activity [GO:0005031]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; tumor necrosis factor receptor activity [GO:0005031]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell adhesion [GO:0045785]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Q9Y5U8	reviewed	MPC1_HUMAN	Mitochondrial pyruvate carrier 1 (Brain protein 44-like protein)	MPC1 BRP44L CGI-129 HSPC040 PNAS-115	Homo sapiens (Human)	109	FUNCTION: Mediates the uptake of pyruvate into mitochondria. {ECO:0000269|PubMed:22628558, ECO:0000269|PubMed:26253029, ECO:0000269|PubMed:27317664}.		mitochondrial pyruvate transmembrane transport [GO:0006850]	inner mitochondrial membrane protein complex [GO:0098800]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	pyruvate transmembrane transporter activity [GO:0050833]	inner mitochondrial membrane protein complex [GO:0098800]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; pyruvate transmembrane transporter activity [GO:0050833]; mitochondrial pyruvate transmembrane transport [GO:0006850]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:22628558, ECO:0000269|PubMed:26253029}; Multi-pass membrane protein {ECO:0000255}.
Q9Y5U9	reviewed	IR3IP_HUMAN	Immediate early response 3-interacting protein 1	IER3IP1 HSPC039	Homo sapiens (Human)	82	FUNCTION: Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size (PubMed:33122427). Required for secretion of extracellular matrix proteins (PubMed:33122427). Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors (PubMed:33122427). Acts as a regulator of the unfolded protein response (UPR) (By similarity). {ECO:0000250|UniProtKB:Q9CR20, ECO:0000269|PubMed:33122427}.		brain development [GO:0007420]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; organ growth [GO:0035265]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; positive regulation of protein secretion [GO:0050714]; protein transport [GO:0015031]; regulation of fibroblast apoptotic process [GO:2000269]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]		COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; brain development [GO:0007420]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; organ growth [GO:0035265]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; positive regulation of protein secretion [GO:0050714]; protein transport [GO:0015031]; regulation of fibroblast apoptotic process [GO:2000269]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15276200, ECO:0000305|PubMed:33122427}; Multi-pass membrane protein {ECO:0000255}.
Q9Y5V3	reviewed	MAGD1_HUMAN	Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog)	MAGED1 NRAGE PP2250 PRO2292	Homo sapiens (Human)	778	FUNCTION: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}.		circadian regulation of gene expression [GO:0032922]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; protein localization to nucleus [GO:0034504]; regulation of apoptotic process [GO:0042981]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713]; circadian regulation of gene expression [GO:0032922]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; protein localization to nucleus [GO:0034504]; regulation of apoptotic process [GO:0042981]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.
Q9Y5W3	reviewed	KLF2_HUMAN	Krueppel-like factor 2 (Lung krueppel-like factor)	KLF2 LKLF	Homo sapiens (Human)	355	FUNCTION: Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758). {ECO:0000269|PubMed:21063504, ECO:0000269|PubMed:28167758}.		cell morphogenesis [GO:0000902]; cellular response to cycloheximide [GO:0071409]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to peptide [GO:1901653]; cellular response to tumor necrosis factor [GO:0071356]; cellular stress response to acid chemical [GO:0097533]; epigenetic regulation of gene expression [GO:0040029]; erythrocyte maturation [GO:0043249]; in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; regulation of transcription by RNA polymerase II [GO:0006357]; type I pneumocyte differentiation [GO:0060509]; vasodilation [GO:0042311]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell morphogenesis [GO:0000902]; cellular response to cycloheximide [GO:0071409]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to peptide [GO:1901653]; cellular response to tumor necrosis factor [GO:0071356]; cellular stress response to acid chemical [GO:0097533]; epigenetic regulation of gene expression [GO:0040029]; erythrocyte maturation [GO:0043249]; in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; regulation of transcription by RNA polymerase II [GO:0006357]; type I pneumocyte differentiation [GO:0060509]; vasodilation [GO:0042311]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9Y5W5	reviewed	WIF1_HUMAN	Wnt inhibitory factor 1 (WIF-1)	WIF1 UNQ191/PRO217	Homo sapiens (Human)	379	FUNCTION: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.		anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; negative regulation of Wnt signaling pathway [GO:0030178]; nodal signaling pathway [GO:0038092]; positive regulation of fat cell differentiation [GO:0045600]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	cell surface [GO:0009986]; extracellular region [GO:0005576]	activin receptor binding [GO:0070697]; nodal binding [GO:0038100]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; extracellular region [GO:0005576]; activin receptor binding [GO:0070697]; nodal binding [GO:0038100]; Wnt-protein binding [GO:0017147]; anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; negative regulation of Wnt signaling pathway [GO:0030178]; nodal signaling pathway [GO:0038092]; positive regulation of fat cell differentiation [GO:0045600]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Secreted.
Q9Y5W7	reviewed	SNX14_HUMAN	Sorting nexin-14	SNX14	Homo sapiens (Human)	946	FUNCTION: Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes (PubMed:25848753). Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25848753, PubMed:25148684). {ECO:0000250|UniProtKB:Q8BHY8, ECO:0000269|PubMed:25148684, ECO:0000269|PubMed:25848753, ECO:0000305|PubMed:25848753}.		autophagosome maturation [GO:0097352]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein transport [GO:0015031]	cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; postsynapse [GO:0098794]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]	cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; postsynapse [GO:0098794]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; autophagosome maturation [GO:0097352]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:25848753}; Multi-pass membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:25848753}; Multi-pass membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHY8}.
Q9Y5W8	reviewed	SNX13_HUMAN	Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1)	SNX13 KIAA0713	Homo sapiens (Human)	968	FUNCTION: May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas. {ECO:0000250, ECO:0000269|PubMed:11729322}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	intracellular protein transport [GO:0006886]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]; intracellular protein transport [GO:0006886]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:11729322}; Peripheral membrane protein {ECO:0000269|PubMed:11729322}; Cytoplasmic side {ECO:0000269|PubMed:11729322}.
Q9Y5W9	reviewed	SNX11_HUMAN	Sorting nexin-11	SNX11	Homo sapiens (Human)	270	FUNCTION: Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. {ECO:0000269|PubMed:23615901}.		intracellular protein transport [GO:0006886]; vesicle organization [GO:0016050]	endosome [GO:0005768]; membrane [GO:0016020]	phosphatidylinositol phosphate binding [GO:1901981]	endosome [GO:0005768]; membrane [GO:0016020]; phosphatidylinositol phosphate binding [GO:1901981]; intracellular protein transport [GO:0006886]; vesicle organization [GO:0016050]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endosome {ECO:0000269|PubMed:23615901}.
Q9Y5X0	reviewed	SNX10_HUMAN	Sorting nexin-10	SNX10	Homo sapiens (Human)	201	FUNCTION: Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption. {ECO:0000269|PubMed:17012226, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:22499339}.		bone mineralization involved in bone maturation [GO:0035630]; bone resorption [GO:0045453]; calcium ion homeostasis [GO:0055074]; cellular homeostasis [GO:0019725]; cellular response to leukemia inhibitory factor [GO:1990830]; cilium assembly [GO:0060271]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; gastric acid secretion [GO:0001696]; intracellular protein transport [GO:0006886]; osteoclast differentiation [GO:0030316]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; ruffle assembly [GO:0097178]; tooth eruption [GO:0044691]; vesicle organization [GO:0016050]	apical cytoplasm [GO:0090651]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extrinsic component of endosome membrane [GO:0031313]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; secretory granule [GO:0030141]	1-phosphatidylinositol binding [GO:0005545]; ATPase binding [GO:0051117]; phosphatidylinositol phosphate binding [GO:1901981]	apical cytoplasm [GO:0090651]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extrinsic component of endosome membrane [GO:0031313]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; secretory granule [GO:0030141]; 1-phosphatidylinositol binding [GO:0005545]; ATPase binding [GO:0051117]; phosphatidylinositol phosphate binding [GO:1901981]; bone mineralization involved in bone maturation [GO:0035630]; bone resorption [GO:0045453]; calcium ion homeostasis [GO:0055074]; cellular homeostasis [GO:0019725]; cellular response to leukemia inhibitory factor [GO:1990830]; cilium assembly [GO:0060271]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; gastric acid secretion [GO:0001696]; intracellular protein transport [GO:0006886]; osteoclast differentiation [GO:0030316]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; ruffle assembly [GO:0097178]; tooth eruption [GO:0044691]; vesicle organization [GO:0016050]	SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May also localize to nucleus and endoplasmic reticulum.
Q9Y5X1	reviewed	SNX9_HUMAN	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A)	SNX9 SH3PX1 SH3PXD3A	Homo sapiens (Human)	595	FUNCTION: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.		cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; lipid tube assembly [GO:0060988]; mitotic cytokinesis [GO:0000281]; plasma membrane tubulation [GO:0097320]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of GTPase activity [GO:0043547]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein kinase activity [GO:0045860]; protein-containing complex assembly [GO:0065003]; receptor-mediated endocytosis [GO:0006898]; regulation of synaptic vesicle endocytosis [GO:1900242]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; ruffle [GO:0001726]; trans-Golgi network [GO:0005802]	1-phosphatidylinositol binding [GO:0005545]; Arp2/3 complex binding [GO:0071933]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase binding [GO:0031625]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; ruffle [GO:0001726]; trans-Golgi network [GO:0005802]; 1-phosphatidylinositol binding [GO:0005545]; Arp2/3 complex binding [GO:0071933]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase binding [GO:0031625]; cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; lipid tube assembly [GO:0060988]; mitotic cytokinesis [GO:0000281]; plasma membrane tubulation [GO:0097320]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of GTPase activity [GO:0043547]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein kinase activity [GO:0045860]; protein-containing complex assembly [GO:0065003]; receptor-mediated endocytosis [GO:0006898]; regulation of synaptic vesicle endocytosis [GO:1900242]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
Q9Y5X2	reviewed	SNX8_HUMAN	Sorting nexin-8	SNX8	Homo sapiens (Human)	465	FUNCTION: May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network. {ECO:0000269|PubMed:19782049}.		early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]	identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:19782049}; Peripheral membrane protein {ECO:0000269|PubMed:19782049}; Cytoplasmic side {ECO:0000269|PubMed:19782049}. Note=Colocalizes with retromer components.
Q9Y5X3	reviewed	SNX5_HUMAN	Sorting nexin-5	SNX5	Homo sapiens (Human)	404	FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941). {ECO:0000269|PubMed:18854019, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:15561769, ECO:0000303|PubMed:19619496, ECO:0000303|PubMed:23085988}.		epidermal growth factor catabolic process [GO:0007174]; intracellular protein transport [GO:0006886]; negative regulation of blood pressure [GO:0045776]; pinocytosis [GO:0006907]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin receptor signaling pathway [GO:0046628]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]	brush border [GO:0005903]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; macropinocytic cup [GO:0070685]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; ruffle [GO:0001726]; tubular endosome [GO:0097422]	cadherin binding [GO:0045296]; D1 dopamine receptor binding [GO:0031748]; dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]	brush border [GO:0005903]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; macropinocytic cup [GO:0070685]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; ruffle [GO:0001726]; tubular endosome [GO:0097422]; cadherin binding [GO:0045296]; D1 dopamine receptor binding [GO:0031748]; dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; epidermal growth factor catabolic process [GO:0007174]; intracellular protein transport [GO:0006886]; negative regulation of blood pressure [GO:0045776]; pinocytosis [GO:0006907]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin receptor signaling pathway [GO:0046628]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:11485546}. Early endosome {ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:24610942}. Early endosome membrane {ECO:0000269|PubMed:15561769}; Peripheral membrane protein; Cytoplasmic side. Cell membrane {ECO:0000269|PubMed:15561769}; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:18854019}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) (PubMed:15561769). Detected on macropinosomes (PubMed:16968745, PubMed:21048941). Targeted to membrane ruffles in response to EGFR stimulation. {ECO:0000269|PubMed:15561769, ECO:0000269|PubMed:16968745, ECO:0000269|PubMed:21048941}.
Q9Y5X4	reviewed	NR2E3_HUMAN	Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor)	NR2E3 PNR RNR	Homo sapiens (Human)	410	FUNCTION: Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. {ECO:0000269|PubMed:15689355, ECO:0000269|PubMed:24069298}.		anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; eye photoreceptor cell development [GO:0042462]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; visual perception [GO:0007601]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]; anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; eye photoreceptor cell development [GO:0042462]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:15689355}.
Q9Y5X5	reviewed	NPFF2_HUMAN	Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor)	NPFFR2 GPR74 NPFF2 NPGPR	Homo sapiens (Human)	522	FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.		cellular response to hormone stimulus [GO:0032870]; detection of abiotic stimulus [GO:0009582]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of MAPK cascade [GO:0043408]	actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]; peptide binding [GO:0042277]	actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]; peptide binding [GO:0042277]; cellular response to hormone stimulus [GO:0032870]; detection of abiotic stimulus [GO:0009582]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of MAPK cascade [GO:0043408]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9Y5X9	reviewed	LIPG_HUMAN	Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL) (Phospholipase A1) (EC 3.1.1.32)	LIPG UNQ387/PRO719	Homo sapiens (Human)	500	FUNCTION: Exerts both phospholipase and triglyceride lipase activities (PubMed:12032167, PubMed:10318835, PubMed:10192396). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (PubMed:12032167). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (PubMed:12032167, PubMed:10192396). {ECO:0000269|PubMed:10192396, ECO:0000269|PubMed:10318835, ECO:0000269|PubMed:12032167}.	MISCELLANEOUS: It is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a characteristic that distinguishes it from other members of the family. However, this protein is also expressed in other cell types.	cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; phospholipid catabolic process [GO:0009395]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; regulation of lipoprotein metabolic process [GO:0050746]; response to nutrient [GO:0007584]; reverse cholesterol transport [GO:0043691]; triglyceride catabolic process [GO:0019433]	cell surface [GO:0009986]; early endosome [GO:0005769]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]	1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]; triglyceride lipase activity [GO:0004806]	cell surface [GO:0009986]; early endosome [GO:0005769]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]; triglyceride lipase activity [GO:0004806]; cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; phospholipid catabolic process [GO:0009395]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; regulation of lipoprotein metabolic process [GO:0050746]; response to nutrient [GO:0007584]; reverse cholesterol transport [GO:0043691]; triglyceride catabolic process [GO:0019433]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10318835}.
Q9Y5Y0	reviewed	FLVC1_HUMAN	Heme transporter FLVCR1 (Feline leukemia virus subgroup C receptor-related protein 1) (Feline leukemia virus subgroup C receptor) (hFLVCR)	FLVCR1 FLVCR	Homo sapiens (Human)	555	FUNCTION: [Isoform 1]: Heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies. Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated. {ECO:0000269|PubMed:15369674, ECO:0000269|PubMed:20610401, ECO:0000269|PubMed:23187127, ECO:0000269|PubMed:27923065}.; FUNCTION: [Isoform 1]: (Microbial infection) Confers susceptibility to feline leukemia virus subgroup C (FeLV-C) infection in vitro. {ECO:0000269|PubMed:10400745}.; FUNCTION: [Isoform 2]: Heme b transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. {ECO:0000269|PubMed:23187127}.	MISCELLANEOUS: [Isoform 2]: Has a probable mitochondrial transit peptide at positions 1-38. {ECO:0000305}.	blood vessel development [GO:0001568]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system morphogenesis [GO:0048704]; erythrocyte differentiation [GO:0030218]; erythrocyte maturation [GO:0043249]; head morphogenesis [GO:0060323]; heme biosynthetic process [GO:0006783]; heme export [GO:0097037]; heme transport [GO:0015886]; in utero embryonic development [GO:0001701]; intracellular iron ion homeostasis [GO:0006879]; mitochondrial transport [GO:0006839]; multicellular organism growth [GO:0035264]; regulation of organ growth [GO:0046620]; spleen development [GO:0048536]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]; blood vessel development [GO:0001568]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system morphogenesis [GO:0048704]; erythrocyte differentiation [GO:0030218]; erythrocyte maturation [GO:0043249]; head morphogenesis [GO:0060323]; heme biosynthetic process [GO:0006783]; heme export [GO:0097037]; heme transport [GO:0015886]; in utero embryonic development [GO:0001701]; intracellular iron ion homeostasis [GO:0006879]; mitochondrial transport [GO:0006839]; multicellular organism growth [GO:0035264]; regulation of organ growth [GO:0046620]; spleen development [GO:0048536]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15369674}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion membrane {ECO:0000250|UniProtKB:B2RXV4}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with HADHA. {ECO:0000250|UniProtKB:B2RXV4}.
Q9Y5Y2	reviewed	NUBP2_HUMAN	Cytosolic Fe-S cluster assembly factor NUBP2 (Nucleotide-binding protein 2) (NBP 2)	NUBP2	Homo sapiens (Human)	271	FUNCTION: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure. {ECO:0000250|UniProtKB:Q9R061, ECO:0000255|HAMAP-Rule:MF_03039}.		cell projection organization [GO:0030030]; iron-sulfur cluster assembly [GO:0016226]	centriole [GO:0005814]; cilium [GO:0005929]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616]	4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]	centriole [GO:0005814]; cilium [GO:0005929]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616]; 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; cell projection organization [GO:0030030]; iron-sulfur cluster assembly [GO:0016226]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03039}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03039}. Cytoplasm {ECO:0000269|PubMed:29848660}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9R061}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9R061}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q9R061}. Note=Enriched at the centrosomes during mitosis. Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis (By similarity). Localized at centrioles and in the nucleus at interphase (By similarity). Colocalizes with nubp-1 at prometaphase (By similarity). {ECO:0000250|UniProtKB:Q9R061, ECO:0000255|HAMAP-Rule:MF_03039}.
Q9Y5Y4	reviewed	PD2R2_HUMAN	Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294)	PTGDR2 CRTH2 DL1R GPR44	Homo sapiens (Human)	395	FUNCTION: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcium-mediated signaling [GO:0019722]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; negative regulation of male germ cell proliferation [GO:2000255]; neuropeptide signaling pathway [GO:0007218]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; prostaglandin D receptor activity [GO:0004956]; prostaglandin F receptor activity [GO:0004958]; prostaglandin J receptor activity [GO:0001785]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; prostaglandin D receptor activity [GO:0004956]; prostaglandin F receptor activity [GO:0004958]; prostaglandin J receptor activity [GO:0001785]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcium-mediated signaling [GO:0019722]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; negative regulation of male germ cell proliferation [GO:2000255]; neuropeptide signaling pathway [GO:0007218]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269|PubMed:17207480}.
Q9Y5Y5	reviewed	PEX16_HUMAN	Peroxisomal membrane protein PEX16 (Peroxin-16) (Peroxisomal biogenesis factor 16)	PEX16	Homo sapiens (Human)	336	FUNCTION: Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:12223482, ECO:0000269|PubMed:16717127}.		ER-dependent peroxisome localization [GO:0106101]; ER-dependent peroxisome organization [GO:0032581]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; protein to membrane docking [GO:0022615]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]		cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; ER-dependent peroxisome localization [GO:0106101]; ER-dependent peroxisome organization [GO:0032581]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; protein to membrane docking [GO:0022615]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:11390669, ECO:0000269|PubMed:21768384}; Multi-pass membrane protein {ECO:0000269|PubMed:11390669}.
Q9Y5Y6	reviewed	ST14_HUMAN	Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein)	ST14 PRSS14 SNC19 TADG15	Homo sapiens (Human)	855	FUNCTION: Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (PubMed:10373424). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (PubMed:18843291). Proteolytically cleaves and therefore activates TMPRSS13 (PubMed:28710277). {ECO:0000269|PubMed:10373424, ECO:0000269|PubMed:18843291, ECO:0000269|PubMed:28710277}.		epithelial cell morphogenesis involved in placental branching [GO:0060672]; keratinocyte differentiation [GO:0030216]; neural tube closure [GO:0001843]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	basolateral plasma membrane [GO:0016323]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	basolateral plasma membrane [GO:0016323]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; epithelial cell morphogenesis involved in placental branching [GO:0060672]; keratinocyte differentiation [GO:0030216]; neural tube closure [GO:0001843]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000255}.
Q9Y5Y7	reviewed	LYVE1_HUMAN	Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Hyaluronic acid receptor)	LYVE1 CRSBP1 HAR XLKD1 UNQ230/PRO263	Homo sapiens (Human)	322	FUNCTION: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10037799). Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (PubMed:26823460). {ECO:0000269|PubMed:10037799, ECO:0000269|PubMed:26823460}.		anatomical structure morphogenesis [GO:0009653]; cell-matrix adhesion [GO:0007160]; hyaluronan catabolic process [GO:0030214]; positive regulation of cellular extravasation [GO:0002693]; receptor-mediated endocytosis [GO:0006898]; response to wounding [GO:0009611]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	cargo receptor activity [GO:0038024]; hyaluronic acid binding [GO:0005540]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cargo receptor activity [GO:0038024]; hyaluronic acid binding [GO:0005540]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; anatomical structure morphogenesis [GO:0009653]; cell-matrix adhesion [GO:0007160]; hyaluronan catabolic process [GO:0030214]; positive regulation of cellular extravasation [GO:0002693]; receptor-mediated endocytosis [GO:0006898]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10037799, ECO:0000269|PubMed:26823460}; Single-pass type I membrane protein {ECO:0000269|PubMed:10037799}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. Localizes at cell-cell junctions.
Q9Y5Y9	reviewed	SCNAA_HUMAN	Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)	SCN10A	Homo sapiens (Human)	1956	FUNCTION: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. {ECO:0000269|PubMed:23115331, ECO:0000269|PubMed:9839820}.		AV node cell action potential [GO:0086016]; bundle of His cell action potential [GO:0086043]; calcium ion import across plasma membrane [GO:0098703]; membrane depolarization during action potential [GO:0086010]; odontogenesis of dentin-containing tooth [GO:0042475]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sensory perception [GO:0007600]; sodium ion transmembrane transport [GO:0035725]	axon [GO:0030424]; clathrin complex [GO:0071439]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]	high voltage-gated calcium channel activity [GO:0008331]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated sodium channel activity [GO:0005248]	axon [GO:0030424]; clathrin complex [GO:0071439]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; voltage-gated calcium channel complex [GO:0005891]; voltage-gated sodium channel complex [GO:0001518]; high voltage-gated calcium channel activity [GO:0008331]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated sodium channel activity [GO:0005248]; AV node cell action potential [GO:0086016]; bundle of His cell action potential [GO:0086043]; calcium ion import across plasma membrane [GO:0098703]; membrane depolarization during action potential [GO:0086010]; odontogenesis of dentin-containing tooth [GO:0042475]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sensory perception [GO:0007600]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:D0E0C2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Note=It can be translocated to the cell membrane through association with S100A10. {ECO:0000250}.
Q9Y5Z0	reviewed	BACE2_HUMAN	Beta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase)	BACE2 AEPLC ALP56 ASP21 CDA13 UNQ418/PRO852	Homo sapiens (Human)	518	FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 (PubMed:10591213, PubMed:11083922, PubMed:11423558, PubMed:15857888, PubMed:16816112). Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets (PubMed:23754390). Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112, ECO:0000269|PubMed:21907142, ECO:0000269|PubMed:23754390}.		amyloid-beta metabolic process [GO:0050435]; glucose homeostasis [GO:0042593]; melanosome organization [GO:0032438]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]; proteolysis [GO:0006508]	endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	aspartic-type endopeptidase activity [GO:0004190]	endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; aspartic-type endopeptidase activity [GO:0004190]; amyloid-beta metabolic process [GO:0050435]; glucose homeostasis [GO:0042593]; melanosome organization [GO:0032438]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21907142}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:11423558}. Endoplasmic reticulum. Endosome. Melanosome {ECO:0000269|PubMed:23754390}. Note=Colocalizes with PMEL in stage I and II melanosomes. {ECO:0000269|PubMed:23754390}.
Q9Y5Z4	reviewed	HEBP2_HUMAN	Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL)	HEBP2 C6orf34 SOUL	Homo sapiens (Human)	205	FUNCTION: Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. {ECO:0000269|PubMed:17098234}.			azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]	heme binding [GO:0020037]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; heme binding [GO:0020037]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17098234}. Mitochondrion {ECO:0000269|PubMed:17098234}. Note=Mainly localized to the cytoplasm with a much lower abundance in the mitochondrion. {ECO:0000269|PubMed:17098234}.
Q9Y5Z6	reviewed	B3GT1_HUMAN	Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)	B3GALT1	Homo sapiens (Human)	326	FUNCTION: Beta-1,3-galactosyltransferase that transfers galactose from UDP-alpha-D-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues. {ECO:0000269|PubMed:9582303}.		galactosylceramide biosynthetic process [GO:0006682]; lipid glycosylation [GO:0030259]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity [GO:0047275]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity [GO:0047275]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; galactosylceramide biosynthetic process [GO:0006682]; lipid glycosylation [GO:0030259]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9Y5Z7	reviewed	HCFC2_HUMAN	Host cell factor 2 (HCF-2) (C2 factor)	HCFC2	Homo sapiens (Human)	792			chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; viral process [GO:0016032]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Set1C/COMPASS complex [GO:0048188]	transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Set1C/COMPASS complex [GO:0048188]; transcription coactivator activity [GO:0003713]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10196288}. Nucleus {ECO:0000269|PubMed:10196288}.
Q9Y5Z9	reviewed	UBIA1_HUMAN	UbiA prenyltransferase domain-containing protein 1 (EC 2.5.1.-) (EC 2.5.1.39) (Transitional epithelial response protein 1)	UBIAD1 TERE1	Homo sapiens (Human)	338	FUNCTION: Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10 (PubMed:20953171, PubMed:23374346). MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development (PubMed:20953171). Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4 (PubMed:20953171). Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system (PubMed:23374346). Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress (PubMed:23374346). {ECO:0000269|PubMed:20953171, ECO:0000269|PubMed:23374346}.	MISCELLANEOUS: Strongly down-regulated in transitional cell carcinoma of the bladder and in prostate carcinoma (at protein level) (PubMed:11314041, PubMed:12497587). {ECO:0000305|PubMed:11314041, ECO:0000305|PubMed:12497587}.	menaquinone biosynthetic process [GO:0009234]; ubiquinone biosynthetic process [GO:0006744]; ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate [GO:0032194]; vitamin K biosynthetic process [GO:0042371]; vitamin K metabolic process [GO:0042373]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]	4-hydroxybenzoate decaprenyltransferase activity [GO:0002083]; antioxidant activity [GO:0016209]; prenyltransferase activity [GO:0004659]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; 4-hydroxybenzoate decaprenyltransferase activity [GO:0002083]; antioxidant activity [GO:0016209]; prenyltransferase activity [GO:0004659]; menaquinone biosynthetic process [GO:0009234]; ubiquinone biosynthetic process [GO:0006744]; ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate [GO:0032194]; vitamin K biosynthetic process [GO:0042371]; vitamin K metabolic process [GO:0042373]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20953171}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:23374346}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:20505825}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:11314041}. Nucleus {ECO:0000269|PubMed:11314041, ECO:0000269|PubMed:12497587}.
Q9Y600	reviewed	CSAD_HUMAN	Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Aspartate 1-decarboxylase) (EC 4.1.1.11) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase)	CSAD CSD	Homo sapiens (Human)	493	FUNCTION: Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate. {ECO:0000250|UniProtKB:Q9DBE0}.		L-cysteine catabolic process to hypotaurine [GO:0019449]; L-cysteine catabolic process to taurine [GO:0019452]; taurine biosynthetic process [GO:0042412]	cytoplasm [GO:0005737]	aspartate 1-decarboxylase activity [GO:0004068]; pyridoxal phosphate binding [GO:0030170]; sulfinoalanine decarboxylase activity [GO:0004782]	cytoplasm [GO:0005737]; aspartate 1-decarboxylase activity [GO:0004068]; pyridoxal phosphate binding [GO:0030170]; sulfinoalanine decarboxylase activity [GO:0004782]; L-cysteine catabolic process to hypotaurine [GO:0019449]; L-cysteine catabolic process to taurine [GO:0019452]; taurine biosynthetic process [GO:0042412]	
Q9Y603	reviewed	ETV7_HUMAN	Transcription factor ETV7 (ETS translocation variant 7) (ETS-related protein Tel2) (Tel-related Ets factor) (Transcription factor Tel-2)	ETV7 TEL2 TELB TREF	Homo sapiens (Human)	341	FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity.		animal organ morphogenesis [GO:0009887]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; animal organ morphogenesis [GO:0009887]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus.
Q9Y605	reviewed	MOFA1_HUMAN	MORF4 family-associated protein 1 (Protein PGR1) (Protein associated with MRG of 14 kDa)	MRFAP1 PAM14 PGR1	Homo sapiens (Human)	127				nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]		nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11500496, ECO:0000269|PubMed:12397079}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11500496, ECO:0000269|PubMed:12397079}. Note=Colocalizes with MORF4L1 to cell nuclei. {ECO:0000269|PubMed:11500496, ECO:0000269|PubMed:12397079}.
Q9Y606	reviewed	PUS1_HUMAN	Pseudouridylate synthase 1 homolog (EC 5.4.99.-) (tRNA pseudouridine synthase 1) (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I)	PUS1 PP8985	Homo sapiens (Human)	427	FUNCTION: Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs (PubMed:15772074, PubMed:24722331). Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA (PubMed:24722331). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA (PubMed:24722331). {ECO:0000269|PubMed:15772074, ECO:0000269|PubMed:24722331, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:35051350}.		mitochondrial tRNA pseudouridine synthesis [GO:0070902]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; RNA splicing [GO:0008380]; tRNA pseudouridine synthesis [GO:0031119]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; steroid receptor RNA activator RNA binding [GO:0002153]; tRNA binding [GO:0000049]; tRNA pseudouridine synthase activity [GO:0106029]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; steroid receptor RNA activator RNA binding [GO:0002153]; tRNA binding [GO:0000049]; tRNA pseudouridine synthase activity [GO:0106029]; mitochondrial tRNA pseudouridine synthesis [GO:0070902]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; RNA splicing [GO:0008380]; tRNA pseudouridine synthesis [GO:0031119]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:17056637, ECO:0000305|PubMed:15772074}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:17056637, ECO:0000305|PubMed:15772074}. Cytoplasm {ECO:0000305|PubMed:15772074}.
Q9Y608	reviewed	LRRF2_HUMAN	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)	LRRFIP2	Homo sapiens (Human)	721	FUNCTION: May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333, ECO:0000269|PubMed:19265123}.		regulation of DNA-templated transcription [GO:0006355]; Wnt signaling pathway [GO:0016055]		LRR domain binding [GO:0030275]	LRR domain binding [GO:0030275]; regulation of DNA-templated transcription [GO:0006355]; Wnt signaling pathway [GO:0016055]	
Q9Y613	reviewed	FHOD1_HUMAN	FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1)	FHOD1 FHOS FHOS1	Homo sapiens (Human)	1164	FUNCTION: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}.		cortical actin cytoskeleton organization [GO:0030866]; establishment of centrosome localization [GO:0051660]; nuclear migration [GO:0007097]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stress fiber assembly [GO:0051492]	bleb [GO:0032059]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intercalated disc [GO:0014704]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein self-association [GO:0043621]	bleb [GO:0032059]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intercalated disc [GO:0014704]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein self-association [GO:0043621]; cortical actin cytoskeleton organization [GO:0030866]; establishment of centrosome localization [GO:0051660]; nuclear migration [GO:0007097]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stress fiber assembly [GO:0051492]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic.
Q9Y615	reviewed	ACL7A_HUMAN	Actin-like protein 7A (Actin-like-7-alpha)	ACTL7A	Homo sapiens (Human)	435	FUNCTION: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. {ECO:0000269|PubMed:32923619}.		acrosome assembly [GO:0001675]; single fertilization [GO:0007338]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; male germ cell nucleus [GO:0001673]; motile cilium [GO:0031514]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	structural constituent of cytoskeleton [GO:0005200]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; male germ cell nucleus [GO:0001673]; motile cilium [GO:0031514]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; structural constituent of cytoskeleton [GO:0005200]; acrosome assembly [GO:0001675]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QY84}. Golgi apparatus {ECO:0000250|UniProtKB:Q9QY84}. Cytoplasm {ECO:0000250|UniProtKB:Q9QY84}. Nucleus {ECO:0000250|UniProtKB:Q9QY84}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:32923619}. Note=Detected at the Golgi apparatus during acrosome biogenesis. Detected at the subacrosomal layer in round spermatids. Detected in sperm head and tail. {ECO:0000250|UniProtKB:Q9QY84}.
Q9Y616	reviewed	IRAK3_HUMAN	Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3)	IRAK3	Homo sapiens (Human)	596	FUNCTION: Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:29686383}.		cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein-containing complex disassembly [GO:0043242]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of cytokine production [GO:0001819]; positive regulation of macrophage tolerance induction [GO:0010933]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein phosphorylation [GO:0006468]; regulation of protein-containing complex disassembly [GO:0043244]; response to exogenous dsRNA [GO:0043330]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to peptidoglycan [GO:0032494]; response to virus [GO:0009615]; Toll signaling pathway [GO:0008063]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein-containing complex disassembly [GO:0043242]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of cytokine production [GO:0001819]; positive regulation of macrophage tolerance induction [GO:0010933]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein phosphorylation [GO:0006468]; regulation of protein-containing complex disassembly [GO:0043244]; response to exogenous dsRNA [GO:0043330]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to peptidoglycan [GO:0032494]; response to virus [GO:0009615]; Toll signaling pathway [GO:0008063]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29686383}. Nucleus {ECO:0000269|PubMed:29686383}. Note=In dendritic cells, translocates into the nucleus upon IL33 stimulation. {ECO:0000250|UniProtKB:Q8K4B2}.
Q9Y617	reviewed	SERC_HUMAN	Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT)	PSAT1 PSA	Homo sapiens (Human)	370	FUNCTION: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. {ECO:0000250|UniProtKB:P10658}.		L-serine biosynthetic process [GO:0006564]; pyridoxine biosynthetic process [GO:0008615]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	identical protein binding [GO:0042802]; O-phospho-L-serine:2-oxoglutarate aminotransferase activity [GO:0004648]; pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; identical protein binding [GO:0042802]; O-phospho-L-serine:2-oxoglutarate aminotransferase activity [GO:0004648]; pyridoxal phosphate binding [GO:0030170]; L-serine biosynthetic process [GO:0006564]; pyridoxine biosynthetic process [GO:0008615]	
Q9Y618	reviewed	NCOR2_HUMAN	Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)	NCOR2 CTG26	Homo sapiens (Human)	2514	FUNCTION: Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:23911289}.	MISCELLANEOUS: [Isoform 2]: Contains only the C-terminal receptor-interacting domain and acts as an antirepressor. {ECO:0000305}.	cerebellum development [GO:0021549]; estrous cycle [GO:0044849]; lactation [GO:0007595]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cellular ketone metabolic process [GO:0010565]; response to estradiol [GO:0032355]; response to organonitrogen compound [GO:0010243]	chromatin [GO:0000785]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; Notch binding [GO:0005112]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear retinoid X receptor binding [GO:0046965]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; Notch binding [GO:0005112]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear retinoid X receptor binding [GO:0046965]; transcription corepressor activity [GO:0003714]; cerebellum development [GO:0021549]; estrous cycle [GO:0044849]; lactation [GO:0007595]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cellular ketone metabolic process [GO:0010565]; response to estradiol [GO:0032355]; response to organonitrogen compound [GO:0010243]	SUBCELLULAR LOCATION: Nucleus.
Q9Y619	reviewed	ORNT1_HUMAN	Mitochondrial ornithine transporter 1 (Solute carrier family 25 member 15)	SLC25A15 ORC1 ORNT1 SP1855	Homo sapiens (Human)	301	FUNCTION: Mitochondrial ornithine-citrulline antiporter (PubMed:12807890, PubMed:22262851) (Probable). Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle (PubMed:12807890, PubMed:22262851) (Probable). Lysine and arginine are also transported by the antiport mechanism (PubMed:12807890) (Probable). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2K309, ECO:0000269|PubMed:12807890, ECO:0000269|PubMed:22262851, ECO:0000305|PubMed:10369256, ECO:0000305|PubMed:19242930, ECO:0000305|PubMed:24721342}.		L-arginine transmembrane transport [GO:1903826]; L-lysine transmembrane transport [GO:1903401]; mitochondrial L-ornithine transmembrane transport [GO:1990575]; urea cycle [GO:0000050]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	antiporter activity [GO:0015297]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; antiporter activity [GO:0015297]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]; L-arginine transmembrane transport [GO:1903826]; L-lysine transmembrane transport [GO:1903401]; mitochondrial L-ornithine transmembrane transport [GO:1990575]; urea cycle [GO:0000050]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q12375}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:10369256}; Multi-pass membrane protein {ECO:0000255}.
Q9Y620	reviewed	RA54B_HUMAN	DNA repair and recombination protein RAD54B (EC 3.6.4.-) (RAD54 homolog B)	RAD54B	Homo sapiens (Human)	910	FUNCTION: Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group. {ECO:0000269|PubMed:11782437, ECO:0000269|PubMed:11884632}.		determination of adult lifespan [GO:0008340]; double-strand break repair via homologous recombination [GO:0000724]; mitotic recombination [GO:0006312]; reciprocal meiotic recombination [GO:0007131]; response to ionizing radiation [GO:0010212]; response to xenobiotic stimulus [GO:0009410]	nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; hydrolase activity [GO:0016787]; RNA helicase activity [GO:0003724]	nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; hydrolase activity [GO:0016787]; RNA helicase activity [GO:0003724]; determination of adult lifespan [GO:0008340]; double-strand break repair via homologous recombination [GO:0000724]; mitotic recombination [GO:0006312]; reciprocal meiotic recombination [GO:0007131]; response to ionizing radiation [GO:0010212]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y623	reviewed	MYH4_HUMAN	Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal)	MYH4	Homo sapiens (Human)	1939	FUNCTION: Muscle contraction.		actin filament-based movement [GO:0030048]; ATP metabolic process [GO:0046034]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]	cytoplasm [GO:0005737]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; double-stranded RNA binding [GO:0003725]; microfilament motor activity [GO:0000146]	cytoplasm [GO:0005737]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; double-stranded RNA binding [GO:0003725]; microfilament motor activity [GO:0000146]; actin filament-based movement [GO:0030048]; ATP metabolic process [GO:0046034]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]	SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Q9Y624	reviewed	JAM1_HUMAN	Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321)	F11R JAM1 JCAM UNQ264/PRO301	Homo sapiens (Human)	299	FUNCTION: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840). {ECO:0000250|UniProtKB:O88792, ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913, ECO:0000269|PubMed:11812992}.; FUNCTION: (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. {ECO:0000269|PubMed:11239401}.; FUNCTION: (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. {ECO:0000269|PubMed:25481868}.		actomyosin structure organization [GO:0031032]; cell-cell adhesion [GO:0098609]; cellular response to mechanical stimulus [GO:0071260]; establishment of endothelial intestinal barrier [GO:0090557]; inflammatory response [GO:0006954]; intestinal absorption [GO:0050892]; leukocyte cell-cell adhesion [GO:0007159]; maintenance of blood-brain barrier [GO:0035633]; memory T cell extravasation [GO:0035683]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of Rho protein signal transduction [GO:0035025]; protein localization to bicellular tight junction [GO:1902396]; protein localization to plasma membrane [GO:0072659]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cell shape [GO:0008360]; regulation of cytokine production [GO:0001817]; regulation of cytoskeleton organization [GO:0051493]; regulation of membrane permeability [GO:0090559]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]	cadherin binding [GO:0045296]; integrin binding [GO:0005178]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; virus receptor activity [GO:0001618]	bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]; cadherin binding [GO:0045296]; integrin binding [GO:0005178]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; virus receptor activity [GO:0001618]; actomyosin structure organization [GO:0031032]; cell-cell adhesion [GO:0098609]; cellular response to mechanical stimulus [GO:0071260]; establishment of endothelial intestinal barrier [GO:0090557]; inflammatory response [GO:0006954]; intestinal absorption [GO:0050892]; leukocyte cell-cell adhesion [GO:0007159]; maintenance of blood-brain barrier [GO:0035633]; memory T cell extravasation [GO:0035683]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of Rho protein signal transduction [GO:0035025]; protein localization to bicellular tight junction [GO:1902396]; protein localization to plasma membrane [GO:0072659]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cell shape [GO:0008360]; regulation of cytokine production [GO:0001817]; regulation of cytoskeleton organization [GO:0051493]; regulation of membrane permeability [GO:0090559]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:11171323}. Cell membrane {ECO:0000269|PubMed:11171323}; Single-pass type I membrane protein {ECO:0000269|PubMed:11171323}. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000269|PubMed:11171323}.
Q9Y625	reviewed	GPC6_HUMAN	Glypican-6 [Cleaved into: Secreted glypican-6]	GPC6 UNQ369/PRO705	Homo sapiens (Human)	555	FUNCTION: Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling. {ECO:0000250, ECO:0000269|PubMed:21871017}.		cell migration [GO:0016477]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of signal transduction [GO:0009966]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]	cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]; cell migration [GO:0016477]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.; SUBCELLULAR LOCATION: [Secreted glypican-6]: Secreted, extracellular space {ECO:0000250}.
Q9Y639	reviewed	NPTN_HUMAN	Neuroplastin (Stromal cell-derived receptor 1) (SDR-1)	NPTN SDFR1 SDR1	Homo sapiens (Human)	398	FUNCTION: Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470). Promotes localization of XKR8 at the cell membrane (PubMed:27503893). {ECO:0000250|UniProtKB:P97546, ECO:0000269|PubMed:27503893, ECO:0000269|PubMed:30190470}.		excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; long-term synaptic potentiation [GO:0060291]; negative regulation of cytokine production [GO:0001818]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein phosphorylation [GO:0001934]; regulation of receptor localization to synapse [GO:1902683]	cell surface [GO:0009986]; immunological synapse [GO:0001772]; postsynaptic density [GO:0014069]; presynaptic membrane [GO:0042734]	cell adhesion molecule binding [GO:0050839]; type 1 fibroblast growth factor receptor binding [GO:0005105]	cell surface [GO:0009986]; immunological synapse [GO:0001772]; postsynaptic density [GO:0014069]; presynaptic membrane [GO:0042734]; cell adhesion molecule binding [GO:0050839]; type 1 fibroblast growth factor receptor binding [GO:0005105]; excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; long-term synaptic potentiation [GO:0060291]; negative regulation of cytokine production [GO:0001818]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein phosphorylation [GO:0001934]; regulation of receptor localization to synapse [GO:1902683]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P97546}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97546}.; SUBCELLULAR LOCATION: [Isoform 2]: Postsynaptic density {ECO:0000250|UniProtKB:P97546}.
Q9Y646	reviewed	CBPQ_HUMAN	Carboxypeptidase Q (EC 3.4.17.-) (Lysosomal dipeptidase) (Plasma glutamate carboxypeptidase)	CPQ LCH1 PGCP	Homo sapiens (Human)	472	FUNCTION: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.		peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; thyroid hormone generation [GO:0006590]; tissue regeneration [GO:0042246]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]	carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]; protein homodimerization activity [GO:0042803]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; thyroid hormone generation [GO:0006590]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:10206990}. Golgi apparatus {ECO:0000269|PubMed:10206990}. Lysosome {ECO:0000250}. Secreted {ECO:0000269|PubMed:10206990}. Note=Secretion is stimulated by TSH/thyroid-stimulating hormone, INS/insulin and SST/somatostatin. {ECO:0000250}.
Q9Y653	reviewed	AGRG1_HUMAN	Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) (Protein TM7XN1) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]	ADGRG1 GPR56 TM7LN4 TM7XN1 UNQ540/PRO1083	Homo sapiens (Human)	693	FUNCTION: Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity). {ECO:0000250|UniProtKB:Q8K209, ECO:0000269|PubMed:16757564, ECO:0000269|PubMed:19572147, ECO:0000269|PubMed:21708946, ECO:0000269|PubMed:21724588, ECO:0000269|PubMed:22238662, ECO:0000269|PubMed:24531968}.; FUNCTION: [ADGRG1 N-terminal fragment]: Plays a critical role in cancer progression by activating VEGFA production and angiogenesis through a signaling pathway mediated by PRKCA (PubMed:21724588). {ECO:0000269|PubMed:21724588}.	MISCELLANEOUS: [Isoform 5]: Has no predictable signal peptide. {ECO:0000305}.	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cerebral cortex radial glia-guided migration [GO:0021801]; cerebral cortex regionalization [GO:0021796]; G protein-coupled receptor signaling pathway [GO:0007186]; hematopoietic stem cell homeostasis [GO:0061484]; layer formation in cerebral cortex [GO:0021819]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron migration [GO:2001223]; neural precursor cell proliferation [GO:0061351]; positive regulation of cell adhesion [GO:0045785]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of Rho protein signal transduction [GO:0035025]; protein kinase C signaling [GO:0070528]; Rho protein signal transduction [GO:0007266]; seminiferous tubule development [GO:0072520]; vascular endothelial growth factor production [GO:0010573]	extracellular exosome [GO:0070062]; glial limiting end-foot [GO:0097451]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; G protein-coupled receptor activity [GO:0004930]; heparin binding [GO:0008201]	extracellular exosome [GO:0070062]; glial limiting end-foot [GO:0097451]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; G protein-coupled receptor activity [GO:0004930]; heparin binding [GO:0008201]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cerebral cortex radial glia-guided migration [GO:0021801]; cerebral cortex regionalization [GO:0021796]; G protein-coupled receptor signaling pathway [GO:0007186]; hematopoietic stem cell homeostasis [GO:0061484]; layer formation in cerebral cortex [GO:0021819]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron migration [GO:2001223]; neural precursor cell proliferation [GO:0061351]; positive regulation of cell adhesion [GO:0045785]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of Rho protein signal transduction [GO:0035025]; protein kinase C signaling [GO:0070528]; Rho protein signal transduction [GO:0007266]; seminiferous tubule development [GO:0072520]; vascular endothelial growth factor production [GO:0010573]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21349848, ECO:0000269|PubMed:24949629}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [ADGRG1 N-terminal fragment]: Secreted {ECO:0000269|PubMed:21349848}.; SUBCELLULAR LOCATION: [ADGRG1 C-terminal fragment]: Membrane raft {ECO:0000269|PubMed:24949629}. Note=Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts. {ECO:0000269|PubMed:24949629}.
Q9Y657	reviewed	SPIN1_HUMAN	Spindlin-1 (Ovarian cancer-related protein) (Spindlin1)	SPIN1 OCR SPIN	Homo sapiens (Human)	262	FUNCTION: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. {ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846}.		chromatin organization [GO:0006325]; gamete generation [GO:0007276]; meiotic cell cycle [GO:0051321]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of DNA-templated transcription [GO:0006355]; rRNA transcription [GO:0009303]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	methylated histone binding [GO:0035064]	cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; methylated histone binding [GO:0035064]; chromatin organization [GO:0006325]; gamete generation [GO:0007276]; meiotic cell cycle [GO:0051321]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of DNA-templated transcription [GO:0006355]; rRNA transcription [GO:0009303]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16098913, ECO:0000269|PubMed:29061846}. Nucleus, nucleolus {ECO:0000269|PubMed:21960006}.
Q9Y662	reviewed	HS3SB_HUMAN	Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1) (3-OST-3B) (Heparan sulfate 3-O-sulfotransferase 3B1) (h3-OST-3B)	HS3ST3B1 3OST3B1 HS3ST3B	Homo sapiens (Human)	390	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:10520990, PubMed:9988768). Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2 (PubMed:10520990, PubMed:9988768). The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry (PubMed:10520990). Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:9988768). {ECO:0000269|PubMed:10520990, ECO:0000269|PubMed:9988768}.		branching involved in ureteric bud morphogenesis [GO:0001658]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity [GO:0033872]	Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity [GO:0033872]; branching involved in ureteric bud morphogenesis [GO:0001658]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9Y663	reviewed	HS3SA_HUMAN	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1) (3-OST-3A) (Heparan sulfate 3-O-sulfotransferase 3A1) (h3-OST-3A)	HS3ST3A1 3OST3A1 HS3ST3A UNQ2551/PRO6180	Homo sapiens (Human)	406	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:10520990, PubMed:9988768, PubMed:10608887, PubMed:15304505). Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2 (PubMed:10520990, PubMed:9988768, PubMed:15304505). The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry (PubMed:10520990). Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:10520990). {ECO:0000269|PubMed:10520990, ECO:0000269|PubMed:10608887, ECO:0000269|PubMed:15304505, ECO:0000269|PubMed:9988768}.		branching involved in ureteric bud morphogenesis [GO:0001658]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity [GO:0033872]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity [GO:0033872]; sulfotransferase activity [GO:0008146]; branching involved in ureteric bud morphogenesis [GO:0001658]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9Y664	reviewed	KPTN_HUMAN	KICSTOR complex protein kaptin (Actin-associated protein 2E4)	KPTN	Homo sapiens (Human)	436	FUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000269|PubMed:28199306}.		actin filament organization [GO:0007015]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; negative regulation of TORC1 signaling [GO:1904262]; protein localization to lysosome [GO:0061462]	KICSTOR complex [GO:0140007]; lamellipodium [GO:0030027]; lysosomal membrane [GO:0005765]; postsynaptic actin cytoskeleton [GO:0098871]; stereocilium [GO:0032420]	actin filament binding [GO:0051015]	KICSTOR complex [GO:0140007]; lamellipodium [GO:0030027]; lysosomal membrane [GO:0005765]; postsynaptic actin cytoskeleton [GO:0098871]; stereocilium [GO:0032420]; actin filament binding [GO:0051015]; actin filament organization [GO:0007015]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; negative regulation of TORC1 signaling [GO:1904262]; protein localization to lysosome [GO:0061462]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28199306}. Cell projection, lamellipodium {ECO:0000269|PubMed:10099934, ECO:0000269|PubMed:24239382}. Cell projection, stereocilium {ECO:0000250|UniProtKB:A0A1D5PJB7}. Note=Localization to lysosomes is amino acid-independent (PubMed:28199306). Colocalizes with F-actin (PubMed:24239382). {ECO:0000269|PubMed:24239382, ECO:0000269|PubMed:28199306}.
Q9Y666	reviewed	S12A7_HUMAN	Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4)	SLC12A7 KCC4	Homo sapiens (Human)	1083	FUNCTION: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}.		ammonium import across plasma membrane [GO:0140157]; cell volume homeostasis [GO:0006884]; cellular response to glucose stimulus [GO:0071333]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]	plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]	ammonium transmembrane transporter activity [GO:0008519]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901]	plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; ammonium transmembrane transporter activity [GO:0008519]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901]; ammonium import across plasma membrane [GO:0140157]; cell volume homeostasis [GO:0006884]; cellular response to glucose stimulus [GO:0071333]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10913127}; Multi-pass membrane protein {ECO:0000255}.
Q9Y672	reviewed	ALG6_HUMAN	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase)	ALG6 My046	Homo sapiens (Human)	507	FUNCTION: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein N-linked glycosylation [GO:0006487]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [GO:0042281]; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity [GO:0004583]; glucosyltransferase activity [GO:0046527]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [GO:0042281]; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity [GO:0004583]; glucosyltransferase activity [GO:0046527]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein N-linked glycosylation [GO:0006487]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9Y673	reviewed	ALG5_HUMAN	Dolichyl-phosphate beta-glucosyltransferase (DolP-glucosyltransferase) (EC 2.4.1.117) (Asparagine-linked glycosylation protein 5 homolog)	ALG5 HSPC149	Homo sapiens (Human)	324	FUNCTION: Required for the assembly of lipid-linked oligosaccharides in kidney epithelial cells, and protein N-glycosylation. Required for polycystin-1 (PKD1) glycosylation and maturation. {ECO:0000269|PubMed:35896117}.		determination of left/right symmetry [GO:0007368]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	dolichyl-phosphate beta-glucosyltransferase activity [GO:0004581]; oligosaccharyl transferase activity [GO:0004576]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; dolichyl-phosphate beta-glucosyltransferase activity [GO:0004581]; oligosaccharyl transferase activity [GO:0004576]; determination of left/right symmetry [GO:0007368]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9Y676	reviewed	RT18B_HUMAN	Small ribosomal subunit protein mS40 (28S ribosomal protein S18-2, mitochondrial) (MRP-S18-2) (28S ribosomal protein S18b, mitochondrial) (MRP-S18-b) (Mrps18-b) (S18mt-b) (Small ribosomal subunit protein bS18b)	MRPS18B C6orf14 HSPC183 PTD017	Homo sapiens (Human)	258		MISCELLANEOUS: There are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c) binds to the same site as bacterial bS18, mS40 (bS18b, this protein) binds to a novel location of the 28S small subunit, and mL66 (bS18a) binds to the 39S large subunit. {ECO:0000305|PubMed:27023846}.	mitochondrial translation [GO:0032543]; translation [GO:0006412]	cell junction [GO:0030054]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	structural constituent of ribosome [GO:0003735]	cell junction [GO:0030054]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
Q9Y678	reviewed	COPG1_HUMAN	Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP)	COPG1 COPG	Homo sapiens (Human)	874	FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250, ECO:0000269|PubMed:20674546}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment of Golgi localization [GO:0051683]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; organelle transport along microtubule [GO:0072384]; protein secretion [GO:0009306]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]	structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]; structural molecule activity [GO:0005198]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment of Golgi localization [GO:0051683]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; organelle transport along microtubule [GO:0072384]; protein secretion [GO:0009306]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11056392}. Golgi apparatus membrane {ECO:0000269|PubMed:11056392}; Peripheral membrane protein {ECO:0000269|PubMed:11056392}; Cytoplasmic side {ECO:0000269|PubMed:11056392}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Predominantly located in the cis-Golgi apparatus. {ECO:0000250}.
Q9Y679	reviewed	AUP1_HUMAN	Lipid droplet-regulating VLDL assembly factor AUP1 (Ancient ubiquitous protein 1)	AUP1	Homo sapiens (Human)	410	FUNCTION: Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (PubMed:18711132, PubMed:21857022). Plays a role in lipid droplet formation (PubMed:21857022). Induces lipid droplet clustering (PubMed:24039768). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (PubMed:23223569, PubMed:21127063). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (PubMed:23223569). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (PubMed:28183703). {ECO:0000269|PubMed:18711132, ECO:0000269|PubMed:21127063, ECO:0000269|PubMed:21857022, ECO:0000269|PubMed:23223569, ECO:0000269|PubMed:24039768, ECO:0000269|PubMed:28183703}.; FUNCTION: (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles. {ECO:0000269|PubMed:29902443}.		ER-associated misfolded protein catabolic process [GO:0071712]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipophagy [GO:0061724]; protein localization to lipid droplet [GO:1990044]; response to virus [GO:0009615]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020]	ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625]; ER-associated misfolded protein catabolic process [GO:0071712]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipophagy [GO:0061724]; protein localization to lipid droplet [GO:1990044]; response to virus [GO:0009615]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12042322, ECO:0000269|PubMed:18711132, ECO:0000269|PubMed:21127063, ECO:0000269|PubMed:21857022, ECO:0000269|PubMed:23197321, ECO:0000269|PubMed:23223569}; Peripheral membrane protein {ECO:0000269|PubMed:21127063, ECO:0000269|PubMed:23197321}. Lipid droplet {ECO:0000269|PubMed:21127063, ECO:0000269|PubMed:21857022, ECO:0000269|PubMed:23197321, ECO:0000269|PubMed:23223569, ECO:0000269|PubMed:28183703, ECO:0000269|PubMed:29902443}.; SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:29902443}. Note=(Microbial infection) Upon Dengue virus infection, relocates from lipid droplets to autophagosomes. {ECO:0000269|PubMed:29902443}.
Q9Y680	reviewed	FKBP7_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP7 (PPIase FKBP7) (EC 5.2.1.8) (23 kDa FK506-binding protein) (23 kDa FKBP) (FKBP-23) (FK506-binding protein 7) (FKBP-7) (Rotamase)	FKBP7 FKBP23 UNQ670/PRO1304	Homo sapiens (Human)	222	FUNCTION: PPIases accelerate the folding of proteins during protein synthesis.	MISCELLANEOUS: Binds calcium. {ECO:0000250}.; MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	peptidyl-proline modification [GO:0018208]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	calcium ion binding [GO:0005509]; FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; calcium ion binding [GO:0005509]; FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; peptidyl-proline modification [GO:0018208]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q9Y691	reviewed	KCMB2_HUMAN	Calcium-activated potassium channel subunit beta-2 (BK channel subunit beta-2) (BKbeta2) (Hbeta2) (Calcium-activated potassium channel, subfamily M subunit beta-2) (Charybdotoxin receptor subunit beta-2) (Hbeta3) (K(VCA)beta-2) (Maxi K channel subunit beta-2) (Slo-beta-2)	KCNMB2	Homo sapiens (Human)	235	FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. {ECO:0000269|PubMed:10097176, ECO:0000269|PubMed:10377337}.		action potential [GO:0001508]; detection of calcium ion [GO:0005513]; neuronal action potential [GO:0019228]; potassium ion transport [GO:0006813]; regulation of vasoconstriction [GO:0019229]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	calcium-activated potassium channel activity [GO:0015269]; ion channel inhibitor activity [GO:0008200]; potassium channel regulator activity [GO:0015459]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; calcium-activated potassium channel activity [GO:0015269]; ion channel inhibitor activity [GO:0008200]; potassium channel regulator activity [GO:0015459]; action potential [GO:0001508]; detection of calcium ion [GO:0005513]; neuronal action potential [GO:0019228]; potassium ion transport [GO:0006813]; regulation of vasoconstriction [GO:0019229]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9Y692	reviewed	GMEB1_HUMAN	Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (DNA-binding protein p96PIF) (Parvovirus initiation factor p96) (PIF p96)	GMEB1	Homo sapiens (Human)	573	FUNCTION: Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.		DNA-templated transcription [GO:0006351]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; Hsp27 protein binding [GO:0051008]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; Hsp27 protein binding [GO:0051008]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; DNA-templated transcription [GO:0006351]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=May be also cytoplasmic.
Q9Y694	reviewed	S22A7_HUMAN	Solute carrier family 22 member 7 (Novel liver transporter) (NLT) (Organic anion transporter 2) (hOAT2)	SLC22A7 NLT OAT2	Homo sapiens (Human)	548	FUNCTION: [Isoform 2]: Functions as a Na(+)-independent bidirectional multispecific transporter (PubMed:11327718, PubMed:18216183, PubMed:21446918, PubMed:28945155). Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively (PubMed:11327718, PubMed:25904762). Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides and nucleotides, with cGMP, 2'deoxyguanosine and GMP being the preferred substrates (PubMed:11327718, PubMed:18216183, PubMed:26377792, PubMed:28945155). Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways (PubMed:18216183, PubMed:26377792). Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood (PubMed:21446918). Involved in renal secretion and possible reabsorption of creatinine (PubMed:25904762, PubMed:28945155). Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion (Probable). Also transports alpha-ketoglutarate and urate (PubMed:11327718, PubMed:26377792). Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified (PubMed:26377792). {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:18216183, ECO:0000269|PubMed:21446918, ECO:0000269|PubMed:25904762, ECO:0000269|PubMed:26377792, ECO:0000269|PubMed:28945155, ECO:0000305|PubMed:11907186}.; FUNCTION: [Isoform 1]: Non functional transporter. {ECO:0000269|PubMed:18216183, ECO:0000269|PubMed:26500550}.; FUNCTION: [Isoform 3]: Involved in the uptake of prostaglandin F2-alpha (PGF2-alpha). {ECO:0000269|PubMed:12023506}.	MISCELLANEOUS: [Isoform 2]: Involved in the uptake of clinically used drugs such as penciclovir and anciclovir, and contributes to renal and hepatic drug elimination. {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:28945155, ECO:0000305|PubMed:11855680}.	alpha-ketoglutarate transport [GO:0015742]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; prostaglandin transport [GO:0015732]; xenobiotic metabolic process [GO:0006805]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; transmembrane transporter activity [GO:0022857]; alpha-ketoglutarate transport [GO:0015742]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; prostaglandin transport [GO:0015732]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: [Isoform 2]: Basolateral cell membrane {ECO:0000269|PubMed:12023506, ECO:0000269|PubMed:25904762}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:25904762}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:18216183}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basolateral side of the proximal tubules (PubMed:12023506, PubMed:25904762). Apical side of the renal tubule (PubMed:25904762). {ECO:0000269|PubMed:12023506, ECO:0000269|PubMed:25904762}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:18216183}.
Q9Y696	reviewed	CLIC4_HUMAN	Chloride intracellular channel protein 4 (Intracellular chloride ion channel protein p64H1)	CLIC4	Homo sapiens (Human)	253	FUNCTION: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). {ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}.		angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; chloride transport [GO:0006821]; endothelial cell morphogenesis [GO:0001886]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; fertilization [GO:0009566]; keratinocyte differentiation [GO:0030216]; multicellular organism growth [GO:0035264]; negative regulation of cell migration [GO:0030336]; regulation of cytoskeleton organization [GO:0051493]; regulation of monoatomic ion transmembrane transport [GO:0034765]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; vacuolar acidification [GO:0007035]	actin cytoskeleton [GO:0015629]; apical part of cell [GO:0045177]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microvillus [GO:0005902]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]; voltage-gated monoatomic ion channel activity [GO:0005244]	actin cytoskeleton [GO:0015629]; apical part of cell [GO:0045177]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microvillus [GO:0005902]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; voltage-gated monoatomic ion channel activity [GO:0005244]; angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; chloride transport [GO:0006821]; endothelial cell morphogenesis [GO:0001886]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; fertilization [GO:0009566]; keratinocyte differentiation [GO:0030216]; multicellular organism growth [GO:0035264]; negative regulation of cell migration [GO:0030336]; regulation of cytoskeleton organization [GO:0051493]; regulation of monoatomic ion transmembrane transport [GO:0034765]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; vacuolar acidification [GO:0007035]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14569596}. Cytoplasmic vesicle membrane {ECO:0000305|PubMed:17636002}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000305|PubMed:17636002}. Cell membrane {ECO:0000269|PubMed:18302930}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250|UniProtKB:Q9Z0W7}. Cell junction {ECO:0000269|PubMed:14569596}. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Might not be present in the nucleus of cardiac cells. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:14569596}.
Q9Y697	reviewed	NFS1_HUMAN	Cysteine desulfurase (EC 2.8.1.7)	NFS1 NIFS HUSSY-08	Homo sapiens (Human)	457	FUNCTION: [Isoform Mitochondrial]: Cysteine desulfurase, of the core iron-sulfur cluster (ISC) assembly complex, that catalyzes the desulfuration of L-cysteine to L-alanine, as component of the cysteine desulfurase complex, leading to the formation of a cysteine persulfide intermediate at the active site cysteine residue and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:29097656, PubMed:31101807, PubMed:18650437). The persulfide is then transferred on the flexible Cys loop from the catalytic site of NFS1 to the surface of NFS1 (PubMed:29097656). After the NFS1-linked persulfide sulfur is transferred to one of the conserved Cys residues of the scaffold, a reaction assisted by FXN (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). {ECO:0000250|UniProtKB:Q9H1K1, ECO:0000250|UniProtKB:Q9Z1J3, ECO:0000269|PubMed:18650437, ECO:0000269|PubMed:29097656, ECO:0000269|PubMed:31101807}.; FUNCTION: [Isoform Cytoplasmic]: May catalyze the desulfuration of L-cysteine to L-alanine as component of the cysteine desulfurase complex (NFS1:LYRM4), leading to the formation of a cysteine persulfide intermediate (PubMed:18650437, PubMed:16527810). Acts as a sulfur donor for MOCS3 by transferring the sulfur of the cysteine persulfide intermediate on MOCS3 (PubMed:18650437, PubMed:23593335). {ECO:0000269|PubMed:16527810, ECO:0000269|PubMed:18650437, ECO:0000269|PubMed:23593335}.		[2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; iron incorporation into metallo-sulfur cluster [GO:0018283]; iron-sulfur cluster assembly [GO:0016226]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor metabolic process [GO:0043545]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial iron-sulfur cluster assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine desulfurase activity [GO:0031071]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial iron-sulfur cluster assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine desulfurase activity [GO:0031071]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; [2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; iron incorporation into metallo-sulfur cluster [GO:0018283]; iron-sulfur cluster assembly [GO:0016226]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor metabolic process [GO:0043545]	SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion {ECO:0000269|PubMed:19454487, ECO:0000269|PubMed:23593335, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:30817134, ECO:0000269|PubMed:9885568}.; SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm {ECO:0000269|PubMed:23593335, ECO:0000269|PubMed:30817134, ECO:0000269|PubMed:9885568}. Nucleus {ECO:0000269|PubMed:19454487, ECO:0000269|PubMed:23593335, ECO:0000269|PubMed:9885568}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30817134}.
Q9Y698	reviewed	CCG2_HUMAN	Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2)	CACNG2	Homo sapiens (Human)	323	FUNCTION: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:20805473}.		eye blink reflex [GO:0060082]; membrane depolarization [GO:0051899]; membrane hyperpolarization [GO:0060081]; neuromuscular junction development [GO:0007528]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of protein localization to basolateral plasma membrane [GO:1904510]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; protein targeting to membrane [GO:0006612]; regulation of AMPA receptor activity [GO:2000311]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to calcium ion [GO:0051592]; transmission of nerve impulse [GO:0019226]	AMPA glutamate receptor complex [GO:0032281]; cell surface [GO:0009986]; cerebellar mossy fiber [GO:0044300]; endocytic vesicle membrane [GO:0030666]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; somatodendritic compartment [GO:0036477]; voltage-gated calcium channel complex [GO:0005891]	channel regulator activity [GO:0016247]; ionotropic glutamate receptor binding [GO:0035255]; voltage-gated calcium channel activity [GO:0005245]	AMPA glutamate receptor complex [GO:0032281]; cell surface [GO:0009986]; cerebellar mossy fiber [GO:0044300]; endocytic vesicle membrane [GO:0030666]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; somatodendritic compartment [GO:0036477]; voltage-gated calcium channel complex [GO:0005891]; channel regulator activity [GO:0016247]; ionotropic glutamate receptor binding [GO:0035255]; voltage-gated calcium channel activity [GO:0005245]; eye blink reflex [GO:0060082]; membrane depolarization [GO:0051899]; membrane hyperpolarization [GO:0060081]; neuromuscular junction development [GO:0007528]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of protein localization to basolateral plasma membrane [GO:1904510]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; protein targeting to membrane [GO:0006612]; regulation of AMPA receptor activity [GO:2000311]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to calcium ion [GO:0051592]; transmission of nerve impulse [GO:0019226]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Synapse, synaptosome {ECO:0000250|UniProtKB:Q71RJ2}.
Q9Y6A1	reviewed	POMT1_HUMAN	Protein O-mannosyl-transferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1)	POMT1	Homo sapiens (Human)	747	FUNCTION: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:12369018, PubMed:14699049, PubMed:28512129). Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129). {ECO:0000269|PubMed:12369018, ECO:0000269|PubMed:14699049, ECO:0000269|PubMed:28512129}.		extracellular matrix organization [GO:0030198]; positive regulation of protein O-linked glycosylation [GO:1904100]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]	acrosomal vesicle [GO:0001669]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sarcoplasmic reticulum [GO:0016529]	dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]; metal ion binding [GO:0046872]	acrosomal vesicle [GO:0001669]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sarcoplasmic reticulum [GO:0016529]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]; metal ion binding [GO:0046872]; extracellular matrix organization [GO:0030198]; positive regulation of protein O-linked glycosylation [GO:1904100]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14699049}; Multi-pass membrane protein {ECO:0000269|PubMed:14699049}.
Q9Y6A2	reviewed	CP46A_HUMAN	Cholesterol 24-hydroxylase (CH24H) (EC 1.14.14.25) (Cholesterol 24-monooxygenase) (Cholesterol 24S-hydroxylase) (Cytochrome P450 46A1)	CYP46A1 CYP46	Homo sapiens (Human)	500	FUNCTION: P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:14640697, PubMed:25017465, PubMed:18621681). By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning (By similarity). Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis (PubMed:12077124, PubMed:14640697, PubMed:28190002). Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain (PubMed:25017465). May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole (PubMed:20667828). {ECO:0000250|UniProtKB:Q9WVK8, ECO:0000269|PubMed:10377398, ECO:0000269|PubMed:12077124, ECO:0000269|PubMed:14640697, ECO:0000269|PubMed:18621681, ECO:0000269|PubMed:20667828, ECO:0000269|PubMed:25017465, ECO:0000269|PubMed:28190002}.		bile acid biosynthetic process [GO:0006699]; cholesterol catabolic process [GO:0006707]; nervous system development [GO:0007399]; progesterone metabolic process [GO:0042448]; protein localization to membrane raft [GO:1903044]; regulation of long-term synaptic potentiation [GO:1900271]; sterol metabolic process [GO:0016125]; xenobiotic metabolic process [GO:0006805]	dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; postsynapse [GO:0098794]; presynapse [GO:0098793]	cholesterol 24-hydroxylase activity [GO:0033781]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid hydroxylase activity [GO:0008395]; testosterone 16-beta-hydroxylase activity [GO:0062184]	dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; postsynapse [GO:0098794]; presynapse [GO:0098793]; cholesterol 24-hydroxylase activity [GO:0033781]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid hydroxylase activity [GO:0008395]; testosterone 16-beta-hydroxylase activity [GO:0062184]; bile acid biosynthetic process [GO:0006699]; cholesterol catabolic process [GO:0006707]; nervous system development [GO:0007399]; progesterone metabolic process [GO:0042448]; protein localization to membrane raft [GO:1903044]; regulation of long-term synaptic potentiation [GO:1900271]; sterol metabolic process [GO:0016125]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9WVK8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WVK8}. Microsome membrane {ECO:0000250|UniProtKB:Q9WVK8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WVK8}. Postsynapse {ECO:0000250|UniProtKB:Q9WVK8}. Presynapse {ECO:0000250|UniProtKB:Q9WVK8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9WVK8}.
Q9Y6A4	reviewed	CFA20_HUMAN	Cilia- and flagella-associated protein 20 (Basal body up-regulated protein 22) (Transcription factor IIB)	CFAP20 BUG22 C16orf80 GTL3	Homo sapiens (Human)	193	FUNCTION: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (PubMed:24414207). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Involved in the regulation of the size and morphology of cilia (PubMed:24414207). Required for axonemal microtubules polyglutamylation (PubMed:24414207). {ECO:0000269|PubMed:24414207, ECO:0000269|PubMed:36191189}.		cilium assembly [GO:0060271]; positive regulation of cell motility [GO:2000147]; positive regulation of feeding behavior [GO:2000253]; protein polyglutamylation [GO:0018095]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]	axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; extracellular exosome [GO:0070062]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; extracellular exosome [GO:0070062]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; cilium assembly [GO:0060271]; positive regulation of cell motility [GO:2000147]; positive regulation of feeding behavior [GO:2000253]; protein polyglutamylation [GO:0018095]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24414207}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:24414207}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24414207}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:24414207, ECO:0000269|PubMed:36191189}.
Q9Y6A5	reviewed	TACC3_HUMAN	Transforming acidic coiled-coil-containing protein 3 (ERIC-1)	TACC3 ERIC1	Homo sapiens (Human)	838	FUNCTION: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.		cell division [GO:0051301]; cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; microtubule cytoskeleton organization [GO:0000226]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mitotic spindle organization [GO:0007052]; regulation of mitotic spindle organization [GO:0060236]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]		centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; microtubule cytoskeleton organization [GO:0000226]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mitotic spindle organization [GO:0007052]; regulation of mitotic spindle organization [GO:0060236]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17545617}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17545617, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23918938}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9PTG8}. Note=In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles. {ECO:0000269|PubMed:25596274}.
Q9Y6A9	reviewed	SPCS1_HUMAN	Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit)	SPCS1 SPC12 HSPC033	Homo sapiens (Human)	169	FUNCTION: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Dispensable for SPC enzymatic activity (By similarity). {ECO:0000250|UniProtKB:P46965, ECO:0000269|PubMed:34388369}.; FUNCTION: (Microbial infection) Required for the post-translational processing of proteins involved in virion assembly and secretion from flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), Yellow Fever virus (YFV), Zika virus (ZIKV) and hepatitis C virus (HCV) (PubMed:24009510, PubMed:27383988, PubMed:29593046). Plays a key role in the post-translational processing of flaviviral structural proteins prM, E, and NS1 (PubMed:27383988, PubMed:29593046). In HCV, it is involved in virion assembly where it promotes the interaction between HCV virus proteins NS2 and E2 (PubMed:24009510). {ECO:0000269|PubMed:24009510, ECO:0000269|PubMed:27383988, ECO:0000269|PubMed:29593046}.		protein targeting to ER [GO:0045047]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465]; viral protein processing [GO:0019082]; virion assembly [GO:0019068]	endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787]		endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787]; protein targeting to ER [GO:0045047]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465]; viral protein processing [GO:0019082]; virion assembly [GO:0019068]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P83362}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P83362}.
Q9Y6B2	reviewed	EID1_HUMAN	EP300-interacting inhibitor of differentiation 1 (21 kDa pRb-associated protein) (CREBBP/EP300 inhibitory protein 1) (E1A-like inhibitor of differentiation 1) (EID-1)	EID1 C15orf3 CRI1 RBP21 PNAS-22 PTD014	Homo sapiens (Human)	187	FUNCTION: Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms. {ECO:0000269|PubMed:11073989, ECO:0000269|PubMed:11073990}.	MISCELLANEOUS: Inhibition of MYOD1 may be partly due to the ability of EID1 to bind and inhibit EP300 histone acetyltransferase activity. {ECO:0000269|PubMed:11073990}.	cell cycle [GO:0007049]; cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654]	histone acetyltransferase binding [GO:0035035]; transcription corepressor activity [GO:0003714]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654]; histone acetyltransferase binding [GO:0035035]; transcription corepressor activity [GO:0003714]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11223246}. Cytoplasm {ECO:0000269|PubMed:11223246}. Note=May shuttle between nucleus and cytoplasm. {ECO:0000250|UniProtKB:Q9DCR4, ECO:0000269|PubMed:11223246}.
Q9Y6B6	reviewed	SAR1B_HUMAN	GTP-binding protein SAR1b (GTP-binding protein B) (GTBPB)	SAR1B SARA2 SARB	Homo sapiens (Human)	198	FUNCTION: GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Activated by the guanine nucleotide exchange factor PREB (By similarity). Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity). Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed:33186557). {ECO:0000250|UniProtKB:Q9QVY3, ECO:0000269|PubMed:33186557}.		antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; lipid homeostasis [GO:0055088]; lipoprotein transport [GO:0042953]; membrane organization [GO:0061024]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; regulation of COPII vesicle coating [GO:0003400]; regulation of lipid transport [GO:0032368]; vesicle organization [GO:0016050]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi cisterna membrane [GO:0032580]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi cisterna membrane [GO:0032580]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; lipid homeostasis [GO:0055088]; lipoprotein transport [GO:0042953]; membrane organization [GO:0061024]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; regulation of COPII vesicle coating [GO:0003400]; regulation of lipid transport [GO:0032368]; vesicle organization [GO:0016050]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9QVY3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9QVY3}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9QVY3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9QVY3}. Note=Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region. {ECO:0000250|UniProtKB:Q9QVY3}.
Q9Y6B7	reviewed	AP4B1_HUMAN	AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin)	AP4B1	Homo sapiens (Human)	739	FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}.		protein localization [GO:0008104]; protein localization to somatodendritic compartment [GO:0061938]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192]	AP-4 adaptor complex [GO:0030124]; clathrin adaptor complex [GO:0030131]; cytoplasmic side of trans-Golgi network transport vesicle membrane [GO:0098541]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	clathrin binding [GO:0030276]	AP-4 adaptor complex [GO:0030124]; clathrin adaptor complex [GO:0030131]; cytoplasmic side of trans-Golgi network transport vesicle membrane [GO:0098541]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; clathrin binding [GO:0030276]; protein localization [GO:0008104]; protein localization to somatodendritic compartment [GO:0061938]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000269|PubMed:22472443}; Peripheral membrane protein {ECO:0000269|PubMed:10066790}.
Q9Y6C2	reviewed	EMIL1_HUMAN	EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1)	EMILIN1 EMI	Homo sapiens (Human)	1016	FUNCTION: May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.	MISCELLANEOUS: Its deposition precedes the appearance of elastin and is simultaneous with that of fibrillin 1.	aortic valve morphogenesis [GO:0003180]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; elastic fiber assembly [GO:0048251]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell activation [GO:0050866]; negative regulation of cell migration [GO:0030336]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of collagen fibril organization [GO:1904027]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of gene expression [GO:0010629]; negative regulation of macrophage migration [GO:1905522]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of gene expression [GO:0010628]; positive regulation of platelet aggregation [GO:1901731]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; EMILIN complex [GO:1990971]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integrin alpha4-beta1 complex [GO:0034668]	extracellular matrix constituent conferring elasticity [GO:0030023]; identical protein binding [GO:0042802]; integrin binding involved in cell-matrix adhesion [GO:0098640]; molecular adaptor activity [GO:0060090]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; EMILIN complex [GO:1990971]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integrin alpha4-beta1 complex [GO:0034668]; extracellular matrix constituent conferring elasticity [GO:0030023]; identical protein binding [GO:0042802]; integrin binding involved in cell-matrix adhesion [GO:0098640]; molecular adaptor activity [GO:0060090]; aortic valve morphogenesis [GO:0003180]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; elastic fiber assembly [GO:0048251]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell activation [GO:0050866]; negative regulation of cell migration [GO:0030336]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of collagen fibril organization [GO:1904027]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of gene expression [GO:0010629]; negative regulation of macrophage migration [GO:1905522]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of gene expression [GO:0010628]; positive regulation of platelet aggregation [GO:1901731]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:26462740, ECO:0000269|PubMed:31978608}. Note=Found mainly at the interface between amorphous elastin and microfibrils. {ECO:0000303|PubMed:10625608}.
Q9Y6C5	reviewed	PTC2_HUMAN	Protein patched homolog 2 (PTC2)	PTCH2 UNQ560/PRO1121/PRO57079	Homo sapiens (Human)	1203	FUNCTION: Plays a role in the control of cellular growth (PubMed:18285427). May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH). {ECO:0000269|PubMed:18285427}.		cell fate determination [GO:0001709]; epidermal cell fate specification [GO:0009957]; hair cycle [GO:0042633]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of epidermal cell differentiation [GO:0045606]; regulation of cell growth [GO:0001558]; skin development [GO:0043588]	plasma membrane [GO:0005886]	hedgehog family protein binding [GO:0097108]; hedgehog receptor activity [GO:0008158]; smoothened binding [GO:0005119]	plasma membrane [GO:0005886]; hedgehog family protein binding [GO:0097108]; hedgehog receptor activity [GO:0008158]; smoothened binding [GO:0005119]; cell fate determination [GO:0001709]; epidermal cell fate specification [GO:0009957]; hair cycle [GO:0042633]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of epidermal cell differentiation [GO:0045606]; regulation of cell growth [GO:0001558]; skin development [GO:0043588]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9Y6C9	reviewed	MTCH2_HUMAN	Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein)	MTCH2 MIMP HSPC032	Homo sapiens (Human)	303	FUNCTION: Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (PubMed:36264797). Does not mediate insertion of beta-barrel transmembrane proteins (PubMed:36264797). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity). {ECO:0000250|UniProtKB:Q791V5, ECO:0000269|PubMed:36264797}.		lipid homeostasis [GO:0055088]; positive regulation of apoptotic process [GO:0043065]; positive regulation of stem cell differentiation [GO:2000738]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein localization to mitochondrion [GO:0070585]; regulation of mitochondrial fusion [GO:0010635]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	membrane insertase activity [GO:0032977]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; membrane insertase activity [GO:0032977]; lipid homeostasis [GO:0055088]; positive regulation of apoptotic process [GO:0043065]; positive regulation of stem cell differentiation [GO:2000738]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein localization to mitochondrion [GO:0070585]; regulation of mitochondrial fusion [GO:0010635]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:36264797}; Multi-pass membrane protein {ECO:0000255}.
Q9Y6D0	reviewed	SELK_HUMAN	Selenoprotein K (SelK)	SELENOK SELK HSPC030 HSPC297	Homo sapiens (Human)	94	FUNCTION: Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (PubMed:20692228). Protects cells from oxidative stress when overexpressed in cardiomyocytes (PubMed:16962588). {ECO:0000250|UniProtKB:Q9JLJ1, ECO:0000269|PubMed:16962588, ECO:0000269|PubMed:20692228, ECO:0000269|PubMed:22016385, ECO:0000269|PubMed:25368151}.		calcium ion transport [GO:0006816]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; establishment of localization in cell [GO:0051649]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; macrophage derived foam cell differentiation [GO:0010742]; neutrophil migration [GO:1990266]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; protein palmitoylation [GO:0018345]; regulation of calcium-mediated signaling [GO:0050848]; regulation of protein transport [GO:0051223]; respiratory burst after phagocytosis [GO:0045728]; response to oxidative stress [GO:0006979]; T cell migration [GO:0072678]; T cell proliferation [GO:0042098]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; calcium ion transport [GO:0006816]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; establishment of localization in cell [GO:0051649]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; macrophage derived foam cell differentiation [GO:0010742]; neutrophil migration [GO:1990266]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; protein palmitoylation [GO:0018345]; regulation of calcium-mediated signaling [GO:0050848]; regulation of protein transport [GO:0051223]; respiratory burst after phagocytosis [GO:0045728]; response to oxidative stress [GO:0006979]; T cell migration [GO:0072678]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16962588, ECO:0000269|PubMed:21220695, ECO:0000269|PubMed:22016385, ECO:0000269|PubMed:25368151}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:12775843}; Single-pass membrane protein {ECO:0000255}. Note=Probably mainly localized in the ER. {ECO:0000269|PubMed:21220695}.
Q9Y6D5	reviewed	BIG2_HUMAN	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)	ARFGEF2 ARFGEP2 BIG2	Homo sapiens (Human)	1785	FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}.		endomembrane system organization [GO:0010256]; endosome organization [GO:0007032]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular signal transduction [GO:0035556]; positive regulation of tumor necrosis factor production [GO:0032760]; protein transport [GO:0015031]; receptor recycling [GO:0001881]; regulation of ARF protein signal transduction [GO:0032012]	asymmetric synapse [GO:0032279]; axonemal microtubule [GO:0005879]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; symmetric synapse [GO:0032280]; trans-Golgi network [GO:0005802]	GABA receptor binding [GO:0050811]; guanyl-nucleotide exchange factor activity [GO:0005085]; myosin binding [GO:0017022]; protein kinase A regulatory subunit binding [GO:0034237]	asymmetric synapse [GO:0032279]; axonemal microtubule [GO:0005879]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; symmetric synapse [GO:0032280]; trans-Golgi network [GO:0005802]; GABA receptor binding [GO:0050811]; guanyl-nucleotide exchange factor activity [GO:0005085]; myosin binding [GO:0017022]; protein kinase A regulatory subunit binding [GO:0034237]; endomembrane system organization [GO:0010256]; endosome organization [GO:0007032]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular signal transduction [GO:0035556]; positive regulation of tumor necrosis factor production [GO:0032760]; protein transport [GO:0015031]; receptor recycling [GO:0001881]; regulation of ARF protein signal transduction [GO:0032012]	SUBCELLULAR LOCATION: Cytoplasm. Membrane. Golgi apparatus. Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network {ECO:0000250}. Endosome {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, dendrite {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Synapse {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Translocates from cytoplasm to membranes upon cAMP treatment. Localized in recycling endosomes.
Q9Y6D6	reviewed	BIG1_HUMAN	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)	ARFGEF1 ARFGEP1 BIG1	Homo sapiens (Human)	1849	FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}.		endomembrane system organization [GO:0010256]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of GTPase activity [GO:0034260]; positive regulation of wound healing [GO:0090303]; protein glycosylation [GO:0006486]; protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of establishment of cell polarity [GO:2000114]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; small nuclear ribonucleoprotein complex [GO:0030532]; trans-Golgi network [GO:0005802]	guanyl-nucleotide exchange factor activity [GO:0005085]; myosin binding [GO:0017022]; protein kinase A regulatory subunit binding [GO:0034237]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; small nuclear ribonucleoprotein complex [GO:0030532]; trans-Golgi network [GO:0005802]; guanyl-nucleotide exchange factor activity [GO:0005085]; myosin binding [GO:0017022]; protein kinase A regulatory subunit binding [GO:0034237]; endomembrane system organization [GO:0010256]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of GTPase activity [GO:0034260]; positive regulation of wound healing [GO:0090303]; protein glycosylation [GO:0006486]; protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of establishment of cell polarity [GO:2000114]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus {ECO:0000269|PubMed:12571360}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27373159, ECO:0000269|PubMed:27436755}. Nucleus {ECO:0000269|PubMed:14973189}. Nucleus, nucleolus {ECO:0000269|PubMed:14973189}. Nucleus matrix {ECO:0000269|PubMed:14973189}. Note=Translocates from cytoplasm to membranes and nucleus upon cAMP treatment.
Q9Y6D9	reviewed	MD1L1_HUMAN	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181)	MAD1L1 MAD1 TXBP181	Homo sapiens (Human)	718	FUNCTION: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}.		attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; cytoplasmic sequestering of protein [GO:0051220]; deactivation of mitotic spindle assembly checkpoint [GO:1902426]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of metaphase plate congression [GO:0090235]; thymus development [GO:0048538]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; MAD1 complex [GO:1990706]; mitotic spindle [GO:0072686]; mitotic spindle assembly checkpoint MAD1-MAD2 complex [GO:1990728]; nuclear pore nuclear basket [GO:0044615]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle pole [GO:0000922]	identical protein binding [GO:0042802]; kinetochore binding [GO:0043515]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; MAD1 complex [GO:1990706]; mitotic spindle [GO:0072686]; mitotic spindle assembly checkpoint MAD1-MAD2 complex [GO:1990728]; nuclear pore nuclear basket [GO:0044615]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle pole [GO:0000922]; identical protein binding [GO:0042802]; kinetochore binding [GO:0043515]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; cytoplasmic sequestering of protein [GO:0051220]; deactivation of mitotic spindle assembly checkpoint [GO:1902426]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of metaphase plate congression [GO:0090235]; thymus development [GO:0048538]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19010891, ECO:0000269|PubMed:9546394}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:29162720}. Nucleus envelope {ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:22351768}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:9546394}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9546394}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:22351768}. Note=Co-localizes with TPR at the nucleus envelope during interphase and throughout the cell cycle (PubMed:22351768, PubMed:18981471). From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody (PubMed:9546394). Localizes to kinetochores during prometaphase (PubMed:22351768, PubMed:29162720). Does not localize to kinetochores during metaphase (PubMed:29162720). Colocalizes with NEK2 at the kinetochore (PubMed:14978040). Colocalizes with IK at spindle poles during metaphase and anaphase (PubMed:22351768). {ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:9546394}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:19010891}.
Q9Y6E0	reviewed	STK24_HUMAN	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)]	STK24 MST3 STK3	Homo sapiens (Human)	443	FUNCTION: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}.		cellular response to starvation [GO:0009267]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of cell migration [GO:0030336]; positive regulation of axon regeneration [GO:0048680]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon regeneration [GO:0048679]; response to hydrogen peroxide [GO:0042542]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; cellular response to starvation [GO:0009267]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of cell migration [GO:0030336]; positive regulation of axon regeneration [GO:0048680]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon regeneration [GO:0048679]; response to hydrogen peroxide [GO:0042542]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.
Q9Y6E2	reviewed	5MP1_HUMAN	eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2)	BZW2 5MP1 HSPC028 MSTP017	Homo sapiens (Human)	419	FUNCTION: Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:34260931, PubMed:29470543). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931). {ECO:0000269|PubMed:21745818, ECO:0000269|PubMed:28981728, ECO:0000269|PubMed:29470543, ECO:0000269|PubMed:34260931}.		regulation of translational initiation [GO:0006446]	cytoplasm [GO:0005737]; membrane [GO:0016020]	cadherin binding [GO:0045296]	cytoplasm [GO:0005737]; membrane [GO:0016020]; cadherin binding [GO:0045296]; regulation of translational initiation [GO:0006446]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21745818}.
Q9Y6E7	reviewed	SIR4_HUMAN	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein biotinylase sirtuin-4) (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)	SIRT4 SIR2L4	Homo sapiens (Human)	314	FUNCTION: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase (PubMed:16959573, PubMed:17715127, PubMed:24052263, PubMed:25525879). Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications (PubMed:24052263, PubMed:25525879). Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity (PubMed:16959573, PubMed:17715127). Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573, PubMed:17715127). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation (PubMed:23663782). Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Does not seem to deacetylate PC (PubMed:23438705). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation (PubMed:24043310). Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310). Down-regulates insulin secretion (PubMed:17715127). {ECO:0000255|HAMAP-Rule:MF_03161, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:17715127, ECO:0000269|PubMed:23438705, ECO:0000269|PubMed:23562301, ECO:0000269|PubMed:23663782, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:24052263, ECO:0000269|PubMed:25525879}.	MISCELLANEOUS: Expression is down-regulated in a number of cancers, while overexpression reduces cell proliferation, transformation, and tumor development (PubMed:23562301, PubMed:23663782). {ECO:0000305|PubMed:23562301, ECO:0000305|PubMed:23663782}.; MISCELLANEOUS: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant. {ECO:0000255|HAMAP-Rule:MF_03161}.	cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; glutamine metabolic process [GO:0006541]; mitochondrion organization [GO:0007005]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of insulin secretion [GO:0046676]; negative regulation of protein processing involved in protein targeting to mitochondrion [GO:1903217]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of lipid biosynthetic process [GO:0046889]; regulation of glutamine family amino acid metabolic process [GO:0000820]; regulation of pyruvate dehydrogenase activity [GO:1904182]; tricarboxylic acid metabolic process [GO:0072350]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	histone deacetylase activity [GO:0004407]; lipoamidase activity [GO:0061690]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD-dependent protein biotinidase activity [GO:0106420]; NAD-dependent protein lipoamidase activity [GO:0106419]; nucleotidyltransferase activity [GO:0016779]; zinc ion binding [GO:0008270]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; histone deacetylase activity [GO:0004407]; lipoamidase activity [GO:0061690]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD-dependent protein biotinidase activity [GO:0106420]; NAD-dependent protein lipoamidase activity [GO:0106419]; nucleotidyltransferase activity [GO:0016779]; zinc ion binding [GO:0008270]; cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; glutamine metabolic process [GO:0006541]; mitochondrion organization [GO:0007005]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of insulin secretion [GO:0046676]; negative regulation of protein processing involved in protein targeting to mitochondrion [GO:1903217]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of lipid biosynthetic process [GO:0046889]; regulation of glutamine family amino acid metabolic process [GO:0000820]; regulation of pyruvate dehydrogenase activity [GO:1904182]; tricarboxylic acid metabolic process [GO:0072350]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03161, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:17715127}.
Q9Y6F1	reviewed	PARP3_HUMAN	Protein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly [ADP-ribose] polymerase 3) (PARP-3) (hPARP-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)	PARP3 ADPRT3 ADPRTL3	Homo sapiens (Human)	533	FUNCTION: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:16924674, PubMed:20064938, PubMed:21211721, PubMed:21270334, PubMed:25043379, PubMed:24598253, PubMed:28447610, PubMed:19354255, PubMed:23742272). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (PubMed:20064938, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6 (PubMed:16924674, PubMed:24598253). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA (PubMed:27530147). Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ (PubMed:24598253). Suppresses G-quadruplex (G4) structures in response to DNA damage (PubMed:28447610). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (PubMed:16924674). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (PubMed:29361132, PubMed:29520010). {ECO:0000250|UniProtKB:Q3ULW8, ECO:0000269|PubMed:16924674, ECO:0000269|PubMed:19354255, ECO:0000269|PubMed:20064938, ECO:0000269|PubMed:21211721, ECO:0000269|PubMed:21270334, ECO:0000269|PubMed:23742272, ECO:0000269|PubMed:24598253, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:27530147, ECO:0000269|PubMed:28447610, ECO:0000269|PubMed:29361132, ECO:0000269|PubMed:29520010}.	MISCELLANEOUS: [Isoform 1]: Most abundant isoform. {ECO:0000269|PubMed:16924674}.	DNA ADP-ribosylation [GO:0030592]; double-strand break repair [GO:0006302]; negative regulation of isotype switching [GO:0045829]; negative regulation of telomerase RNA reverse transcriptase activity [GO:1905662]; positive regulation of DNA ligation [GO:0051106]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to site of double-strand break [GO:1990166]; regulation of mitotic spindle organization [GO:0060236]; telomere maintenance [GO:0000723]	centriole [GO:0005814]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]	catalytic activity [GO:0003824]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+- protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; nucleotidyltransferase activity [GO:0016779]	centriole [GO:0005814]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; catalytic activity [GO:0003824]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+- protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; nucleotidyltransferase activity [GO:0016779]; DNA ADP-ribosylation [GO:0030592]; double-strand break repair [GO:0006302]; negative regulation of isotype switching [GO:0045829]; negative regulation of telomerase RNA reverse transcriptase activity [GO:1905662]; positive regulation of DNA ligation [GO:0051106]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to site of double-strand break [GO:1990166]; regulation of mitotic spindle organization [GO:0060236]; telomere maintenance [GO:0000723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16924674}. Chromosome {ECO:0000269|PubMed:21270334, ECO:0000269|PubMed:27530147, ECO:0000269|PubMed:28447610}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10329013}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:10329013}. Note=Almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected (PubMed:16924674). In response to DNA damage, localizes to sites of double-strand break (PubMed:21270334, PubMed:28447610). Also localizes to single-strand breaks (PubMed:27530147). Preferentially localized to the daughter centriole (PubMed:10329013). {ECO:0000269|PubMed:10329013, ECO:0000269|PubMed:16924674, ECO:0000269|PubMed:21270334, ECO:0000269|PubMed:27530147, ECO:0000269|PubMed:28447610}.
Q9Y6F6	reviewed	IRAG1_HUMAN	Inositol 1,4,5-triphosphate receptor associated 1 (Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate) (JAW1-related protein MRVI1) (Protein MRVI1)	IRAG1 IRAG JAW1L MRVI1	Homo sapiens (Human)	904	FUNCTION: Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. {ECO:0000269|PubMed:14729908}.		cGMP-mediated signaling [GO:0019934]	endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529]		endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529]; cGMP-mediated signaling [GO:0019934]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Sarcoplasmic reticulum {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9Y6F8	reviewed	CDY1_HUMAN	Testis-specific chromodomain protein Y 1 (EC 2.3.1.48)	CDY1 CDY1A; CDY1B	Homo sapiens (Human)	540	FUNCTION: Has histone acetyltransferase activity, with a preference for histone H4. {ECO:0000269|PubMed:12072557}.		spermatogenesis [GO:0007283]	nucleus [GO:0005634]	histone acetyltransferase activity [GO:0004402]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]; histone acetyltransferase activity [GO:0004402]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18450745}.
Q9Y6F9	reviewed	WNT6_HUMAN	Protein Wnt-6	WNT6	Homo sapiens (Human)	365	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway. {ECO:0000269|PubMed:22370641}.		axis specification [GO:0009798]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; cornea development in camera-type eye [GO:0061303]; epithelial-mesenchymal cell signaling [GO:0060684]; nephron tubule formation [GO:0072079]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of tooth mineralization [GO:0070172]	cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]	cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; axis specification [GO:0009798]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; cornea development in camera-type eye [GO:0061303]; epithelial-mesenchymal cell signaling [GO:0060684]; nephron tubule formation [GO:0072079]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of tooth mineralization [GO:0070172]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q9Y6G1	reviewed	TM14A_HUMAN	Transmembrane protein 14A	TMEM14A C6orf73 PTD011	Homo sapiens (Human)	99	FUNCTION: Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. {ECO:0000269|PubMed:21723035}.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; regulation of heme biosynthetic process [GO:0070453]	endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]		endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; regulation of heme biosynthetic process [GO:0070453]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:21723035}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21723035}.
Q9Y6G3	reviewed	RM42_HUMAN	Large ribosomal subunit protein mL42 (39S ribosomal protein L31, mitochondrial) (L31mt) (MRP-L31) (39S ribosomal protein L42, mitochondrial) (L42mt) (MRP-L42)	MRPL42 MRPL31 MRPS32 RPML31 HSPC204 PTD007	Homo sapiens (Human)	142			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279123, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9Y6G5	reviewed	COMDA_HUMAN	COMM domain-containing protein 10	COMMD10 HSPC305 PTD002	Homo sapiens (Human)	202	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.			cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]		cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
Q9Y6G9	reviewed	DC1L1_HUMAN	Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1)	DYNC1LI1 DNCLI1	Homo sapiens (Human)	523	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269|PubMed:19229290, ECO:0000269|PubMed:20026645}.		cell cycle [GO:0007049]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based movement [GO:0007018]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of vesicle-mediated transport [GO:0060627]	centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; ficolin-1-rich granule membrane [GO:0101003]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; spindle pole [GO:0000922]	ATP binding [GO:0005524]; dynein heavy chain binding [GO:0045504]; GDP binding [GO:0019003]; molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723]	centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; ficolin-1-rich granule membrane [GO:0101003]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; dynein heavy chain binding [GO:0045504]; GDP binding [GO:0019003]; molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723]; cell cycle [GO:0007049]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based movement [GO:0007018]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of vesicle-mediated transport [GO:0060627]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19229290}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19229290}. Recycling endosome membrane {ECO:0000269|PubMed:20026645}. Note=During interphase, localized in vesicles continuously moving from peripheral sorting endosomes in the cell towards the pericentrosomal endosomal recycling compartment (ERC). {ECO:0000269|PubMed:20026645}.
Q9Y6H1	reviewed	CHCH2_HUMAN	Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP)	CHCHD2 C7orf17 AAG10	Homo sapiens (Human)	151	FUNCTION: Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). {ECO:0000269|PubMed:23303788}.		cellular response to oxidative stress [GO:0034599]; mitochondrion organization [GO:0007005]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cellular response to hypoxia [GO:1900037]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	DNA-binding transcription factor binding [GO:0140297]; sequence-specific DNA binding [GO:0043565]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; DNA-binding transcription factor binding [GO:0140297]; sequence-specific DNA binding [GO:0043565]; cellular response to oxidative stress [GO:0034599]; mitochondrion organization [GO:0007005]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cellular response to hypoxia [GO:1900037]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23303788}. Mitochondrion {ECO:0000269|PubMed:25662902}. Mitochondrion intermembrane space {ECO:0000269|PubMed:25662902}. Note=Mainly localized in the intermembrane space. {ECO:0000269|PubMed:25662902}.
Q9Y6H3	reviewed	ATP23_HUMAN	Mitochondrial inner membrane protease ATP23 homolog (EC 3.4.24.-) (Ku70-binding protein 3) (XRCC6-binding protein 1)	ATP23 KUB3 XRCC6BP1	Homo sapiens (Human)	246			double-strand break repair via nonhomologous end joining [GO:0006303]; mitochondrial protein processing [GO:0034982]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]	cell junction [GO:0030054]; cytosol [GO:0005829]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	DNA-dependent protein kinase activity [GO:0004677]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	cell junction [GO:0030054]; cytosol [GO:0005829]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; DNA-dependent protein kinase activity [GO:0004677]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; double-strand break repair via nonhomologous end joining [GO:0006303]; mitochondrial protein processing [GO:0034982]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]	
Q9Y6H5	reviewed	SNCAP_HUMAN	Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein)	SNCAIP	Homo sapiens (Human)	919	FUNCTION: Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. {ECO:0000269|PubMed:16595633, ECO:0000269|PubMed:19224863}.	MISCELLANEOUS: Constructs encoding portions of SNCA and SNCAIP co-transfected in mammalian cells promote cytosolic inclusions resembling the Lewy bodies of Parkinson disease. Coexpression of SNCA, SNCAIP, and PRKN result in the formation of Lewy body-like. ubiquitin-positive cytosolic inclusions. SNCAIP isoform 2 is particularly aggregation-prone. Familial mutations in PRKN disrupt the ubiquitination of SNCAIP and the formation of the ubiquitin-positive inclusions. These results provide a molecular basis for the ubiquitination of Lewy body-associated proteins and link PRKN and SNCA in a common pathogenic mechanism through their interaction with SNCAIP.	cell death [GO:0008219]; dopamine metabolic process [GO:0042417]; regulation of inclusion body assembly [GO:0090083]; regulation of neurotransmitter secretion [GO:0046928]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]	identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625]; cell death [GO:0008219]; dopamine metabolic process [GO:0042417]; regulation of inclusion body assembly [GO:0090083]; regulation of neurotransmitter secretion [GO:0046928]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10319874, ECO:0000269|PubMed:15064394, ECO:0000269|PubMed:16595633, ECO:0000269|PubMed:19762560}. Note=Detected in cytoplasmic inclusion bodies, together with SNCA.
Q9Y6H6	reviewed	KCNE3_HUMAN	Potassium voltage-gated channel subfamily E member 3 (MinK-related peptide 2) (Minimum potassium ion channel-related peptide 2) (Potassium channel subunit beta MiRP2)	KCNE3	Homo sapiens (Human)	103	FUNCTION: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. {ECO:0000250|UniProtKB:Q9JJV7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:12954870}.		intracellular chloride ion homeostasis [GO:0030644]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905025]; negative regulation of potassium ion export across plasma membrane [GO:1903765]; negative regulation of voltage-gated potassium channel activity [GO:1903817]; potassium ion export across plasma membrane [GO:0097623]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sodium ion transport [GO:0006814]; ventricular cardiac muscle cell action potential [GO:0086005]	basolateral part of cell [GO:1990794]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; membrane raft [GO:0045121]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	basolateral part of cell [GO:1990794]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; membrane raft [GO:0045121]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; intracellular chloride ion homeostasis [GO:0030644]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905025]; negative regulation of potassium ion export across plasma membrane [GO:1903765]; negative regulation of voltage-gated potassium channel activity [GO:1903817]; potassium ion export across plasma membrane [GO:0097623]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sodium ion transport [GO:0006814]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12954870}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12954870}. Perikaryon {ECO:0000269|PubMed:12954870}. Cell projection, dendrite {ECO:0000269|PubMed:12954870}. Membrane raft {ECO:0000269|PubMed:20533308}. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal neurons. {ECO:0000269|PubMed:12954870}.
Q9Y6H8	reviewed	CXA3_HUMAN	Gap junction alpha-3 protein (Connexin-46) (Cx46)	GJA3	Homo sapiens (Human)	435	FUNCTION: Structural component of lens fiber gap junctions (PubMed:30044662). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells (By similarity). They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:30044662). {ECO:0000250|UniProtKB:Q9TU17, ECO:0000269|PubMed:30044662}.		cell-cell signaling [GO:0007267]; gap junction-mediated intercellular transport [GO:1990349]; visual perception [GO:0007601]	connexin complex [GO:0005922]; plasma membrane [GO:0005886]	gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	connexin complex [GO:0005922]; plasma membrane [GO:0005886]; gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]; cell-cell signaling [GO:0007267]; gap junction-mediated intercellular transport [GO:1990349]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30044662}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9TU17}. Cell junction, gap junction {ECO:0000269|PubMed:30044662}.
Q9Y6I3	reviewed	EPN1_HUMAN	Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)	EPN1	Homo sapiens (Human)	576	FUNCTION: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10557078, PubMed:10393179). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}.	MISCELLANEOUS: [Isoform 3]: May be due to a competing donor splice site. {ECO:0000305}.	embryonic organ development [GO:0048568]; endocytosis [GO:0006897]; female pregnancy [GO:0007565]; in utero embryonic development [GO:0001701]; negative regulation of sprouting angiogenesis [GO:1903671]; Notch signaling pathway [GO:0007219]	clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	clathrin binding [GO:0030276]; molecular sequestering activity [GO:0140313]; phospholipid binding [GO:0005543]	clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; clathrin binding [GO:0030276]; molecular sequestering activity [GO:0140313]; phospholipid binding [GO:0005543]; embryonic organ development [GO:0048568]; endocytosis [GO:0006897]; female pregnancy [GO:0007565]; in utero embryonic development [GO:0001701]; negative regulation of sprouting angiogenesis [GO:1903671]; Notch signaling pathway [GO:0007219]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). {ECO:0000250}.
Q9Y6I4	reviewed	UBP3_HUMAN	Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3)	USP3	Homo sapiens (Human)	520	FUNCTION: Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. {ECO:0000269|PubMed:17980597}.		cell cycle [GO:0007049]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; negative regulation of transcription by RNA polymerase II [GO:0000122]; proteolysis [GO:0006508]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; Flemming body [GO:0090543]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]; histone binding [GO:0042393]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; Flemming body [GO:0090543]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; histone binding [GO:0042393]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; negative regulation of transcription by RNA polymerase II [GO:0000122]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17980597}. Note=Localizes preferentially with monoubiquitinated H2A to chromatin.
Q9Y6I7	reviewed	WSB1_HUMAN	WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1)	WSB1 SWIP1	Homo sapiens (Human)	421	FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:15965468, ECO:0000269|PubMed:18093972}.		intracellular signal transduction [GO:0035556]; protein aggregate center assembly [GO:0140454]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; intracellular signal transduction [GO:0035556]; protein aggregate center assembly [GO:0140454]; protein ubiquitination [GO:0016567]	
Q9Y6I9	reviewed	TX264_HUMAN	Testis-expressed protein 264 (Putative secreted protein Zsig11)	TEX264 ZSIG11 UNQ337/PRO536	Homo sapiens (Human)	313	FUNCTION: Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270). {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538, ECO:0000269|PubMed:32152270}.		protein-DNA covalent cross-linking repair [GO:0106300]; reticulophagy [GO:0061709]	autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; replication fork [GO:0005657]	signaling receptor activity [GO:0038023]	autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; replication fork [GO:0005657]; signaling receptor activity [GO:0038023]; protein-DNA covalent cross-linking repair [GO:0106300]; reticulophagy [GO:0061709]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}; Single-pass type III membrane protein {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}. Cytoplasm, cytosol {ECO:0000269|PubMed:32152270}. Nucleus {ECO:0000269|PubMed:32152270}. Chromosome {ECO:0000269|PubMed:32152270}. Note=Is trafficked from tubular ER to growing autophagosomes via its cytosolic LIR motif (PubMed:31006537). Also found in the cytosol, nucleus and chromatin (PubMed:32152270). In response to formation of covalent DNA-protein cross-links (DPCs), localizes to the nuclear periphery, and associates with DNA replication forks (PubMed:32152270). {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:32152270}.
Q9Y6J0	reviewed	CABIN_HUMAN	Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN)	CABIN1 KIAA0330	Homo sapiens (Human)	2220	FUNCTION: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}.		cell surface receptor signaling pathway [GO:0007166]; nucleosome assembly [GO:0006334]	aggresome [GO:0016235]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein phosphatase inhibitor activity [GO:0004864]	aggresome [GO:0016235]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase inhibitor activity [GO:0004864]; cell surface receptor signaling pathway [GO:0007166]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9655484}.
Q9Y6J6	reviewed	KCNE2_HUMAN	Potassium voltage-gated channel subfamily E member 2 (MinK-related peptide 1) (Minimum potassium ion channel-related peptide 1) (Potassium channel subunit beta MiRP1)	KCNE2	Homo sapiens (Human)	123	FUNCTION: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability. {ECO:0000250|UniProtKB:P63161, ECO:0000250|UniProtKB:Q9D808, ECO:0000269|PubMed:10219239, ECO:0000269|PubMed:11101505}.		cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to xenobiotic stimulus [GO:0071466]; membrane repolarization [GO:0086009]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; positive regulation of proteasomal protein catabolic process [GO:1901800]; potassium ion export across plasma membrane [GO:0097623]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of delayed rectifier potassium channel activity [GO:1902259]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of inward rectifier potassium channel activity [GO:1901979]; regulation of membrane repolarization [GO:0060306]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; tongue development [GO:0043586]; ventricular cardiac muscle cell action potential [GO:0086005]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]; identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to xenobiotic stimulus [GO:0071466]; membrane repolarization [GO:0086009]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; positive regulation of proteasomal protein catabolic process [GO:1901800]; potassium ion export across plasma membrane [GO:0097623]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of delayed rectifier potassium channel activity [GO:1902259]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of inward rectifier potassium channel activity [GO:1901979]; regulation of membrane repolarization [GO:0060306]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; tongue development [GO:0043586]; ventricular cardiac muscle cell action potential [GO:0086005]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20533308}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P63161}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D808}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with KCNB1 at the plasma membrane. {ECO:0000250|UniProtKB:P63161}.
Q9Y6J8	reviewed	STYL1_HUMAN	Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity phosphatase inhibitor MK-STYX) (Dual specificity protein phosphatase 24) (Inactive dual specificity protein phosphatase MK-STYX) (Map kinase phosphatase-like protein MK-STYX)	STYXL1 DUSP24 MKSTYX	Homo sapiens (Human)	313	FUNCTION: Catalytically inactive phosphatase (PubMed:20180778, PubMed:23163895). By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules (PubMed:20180778, PubMed:23163895). Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149' (PubMed:23163895). Inhibits PTPMT1 phosphatase activity (PubMed:24709986). By inhibiting PTPMT1, positively regulates intrinsic apoptosis (PubMed:21262771). May play a role in the formation of neurites during neuronal development (PubMed:29250526). {ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:21262771, ECO:0000269|PubMed:23163895, ECO:0000269|PubMed:24709986, ECO:0000269|PubMed:29250526}.		dephosphorylation [GO:0016311]; intracellular signal transduction [GO:0035556]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of stress granule assembly [GO:0062030]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron projection development [GO:0010976]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; pseudophosphatase activity [GO:0001691]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; pseudophosphatase activity [GO:0001691]; dephosphorylation [GO:0016311]; intracellular signal transduction [GO:0035556]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of stress granule assembly [GO:0062030]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron projection development [GO:0010976]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:21262771}.
Q9Y6J9	reviewed	TAF6L_HUMAN	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) (PCAF-associated factor 65-alpha) (PAF65-alpha)	TAF6L PAF65A	Homo sapiens (Human)	622	FUNCTION: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity). {ECO:0000250|UniProtKB:Q8R2K4, ECO:0000305|PubMed:9674419}.		chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]	extracellular exosome [GO:0070062]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription coactivator activity [GO:0003713]	extracellular exosome [GO:0070062]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription coactivator activity [GO:0003713]; chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9674425}.
Q9Y6K0	reviewed	CEPT1_HUMAN	Choline/ethanolaminephosphotransferase 1 (hCEPT1) (EC 2.7.8.1) (EC 2.7.8.2) (1-alkenyl-2-acylglycerol choline phosphotransferase) (EC 2.7.8.22)	CEPT1 PRO1101	Homo sapiens (Human)	416	FUNCTION: Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. {ECO:0000269|PubMed:10191259, ECO:0000269|PubMed:10893425, ECO:0000269|PubMed:12216837}.		lipid metabolic process [GO:0006629]; phosphatidylethanolamine biosynthetic process [GO:0006646]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear membrane [GO:0031965]	1-alkenyl-2-acylglycerol choline phosphotransferase activity [GO:0047359]; diacylglycerol cholinephosphotransferase activity [GO:0004142]; ethanolaminephosphotransferase activity [GO:0004307]; metal ion binding [GO:0046872]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; 1-alkenyl-2-acylglycerol choline phosphotransferase activity [GO:0047359]; diacylglycerol cholinephosphotransferase activity [GO:0004142]; ethanolaminephosphotransferase activity [GO:0004307]; metal ion binding [GO:0046872]; lipid metabolic process [GO:0006629]; phosphatidylethanolamine biosynthetic process [GO:0006646]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12221122}; Multi-pass membrane protein {ECO:0000269|PubMed:12221122}. Nucleus membrane {ECO:0000269|PubMed:12221122}; Multi-pass membrane protein {ECO:0000269|PubMed:12221122}.
Q9Y6K1	reviewed	DNM3A_HUMAN	DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA)	DNMT3A	Homo sapiens (Human)	912	FUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). {ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}.	MISCELLANEOUS: [Isoform 2]: It is uncertain whether Met-1 or Met-35 is the initiator. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing. {ECO:0000305}.	C-5 methylation of cytosine [GO:0090116]; cellular response to amino acid stimulus [GO:0071230]; cellular response to bisphenol A [GO:1903926]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; DNA methylation [GO:0006306]; DNA methylation on cytosine [GO:0032776]; DNA methylation-dependent heterochromatin formation [GO:0006346]; genomic imprinting [GO:0071514]; hepatocyte apoptotic process [GO:0097284]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of cellular response to hypoxia [GO:1900039]; post-fertilization epigenetic regulation of gene expression [GO:0043045]; regulation of gene expression by genomic imprinting [GO:0006349]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to ionizing radiation [GO:0010212]; response to lead ion [GO:0010288]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]	catalytic complex [GO:1902494]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; XY body [GO:0001741]	chromatin binding [GO:0003682]; DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-cysteine methyltransferase activity [GO:0106363]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; unmethylated CpG binding [GO:0045322]	catalytic complex [GO:1902494]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; XY body [GO:0001741]; chromatin binding [GO:0003682]; DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-cysteine methyltransferase activity [GO:0106363]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; unmethylated CpG binding [GO:0045322]; C-5 methylation of cytosine [GO:0090116]; cellular response to amino acid stimulus [GO:0071230]; cellular response to bisphenol A [GO:1903926]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; DNA methylation [GO:0006306]; DNA methylation on cytosine [GO:0032776]; DNA methylation-dependent heterochromatin formation [GO:0006346]; genomic imprinting [GO:0071514]; hepatocyte apoptotic process [GO:0097284]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of cellular response to hypoxia [GO:1900039]; post-fertilization epigenetic regulation of gene expression [GO:0043045]; regulation of gene expression by genomic imprinting [GO:0006349]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to ionizing radiation [GO:0010212]; response to lead ion [GO:0010288]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:12145218}. Chromosome {ECO:0000269|PubMed:12138111}. Cytoplasm {ECO:0000269|PubMed:12145218}. Note=Accumulates in the major satellite repeats at pericentric heterochromatin. {ECO:0000250|UniProtKB:O88508}.
Q9Y6K5	reviewed	OAS3_HUMAN	2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS)	OAS3 P/OKcl.4	Homo sapiens (Human)	1087	FUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). {ECO:0000269|PubMed:19056102, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880533}.		defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of chemokine (C-X-C motif) ligand 9 production [GO:0035395]; negative regulation of IP-10 production [GO:0071659]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of ribonuclease activity [GO:0060700]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; 2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of chemokine (C-X-C motif) ligand 9 production [GO:0035395]; negative regulation of IP-10 production [GO:0071659]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of ribonuclease activity [GO:0060700]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q9Y6K8	reviewed	KAD5_HUMAN	Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5)	AK5	Homo sapiens (Human)	562	FUNCTION: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:19647735, ECO:0000269|PubMed:23416111}.	MISCELLANEOUS: [Isoform 2]: It is unsure whether Met-1 or Met-5 is the initiator. {ECO:0000305}.	ADP biosynthetic process [GO:0006172]; ATP metabolic process [GO:0046034]; dADP biosynthetic process [GO:0006173]; phosphorylation [GO:0016310]; pyrimidine ribonucleotide biosynthetic process [GO:0009220]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550]; ADP biosynthetic process [GO:0006172]; ATP metabolic process [GO:0046034]; dADP biosynthetic process [GO:0006173]; phosphorylation [GO:0016310]; pyrimidine ribonucleotide biosynthetic process [GO:0009220]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19647735}.
Q9Y6K9	reviewed	NEMO_HUMAN	NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)	IKBKG FIP3 NEMO	Homo sapiens (Human)	419	FUNCTION: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:9751060, PubMed:14695475, PubMed:20724660, PubMed:21518757). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:21606507, PubMed:27777308, PubMed:19185524, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:27777308, PubMed:19033441, PubMed:21606507, PubMed:19185524). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}.		anoikis [GO:0043276]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; establishment of vesicle localization [GO:0051650]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein-containing complex assembly [GO:0065003]; response to virus [GO:0009615]; T cell receptor signaling pathway [GO:0050852]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151]	identical protein binding [GO:0042802]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; linear polyubiquitin binding [GO:1990450]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; signaling adaptor activity [GO:0035591]; transferrin receptor binding [GO:1990459]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151]; identical protein binding [GO:0042802]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; linear polyubiquitin binding [GO:1990450]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; signaling adaptor activity [GO:0035591]; transferrin receptor binding [GO:1990459]; ubiquitin protein ligase binding [GO:0031625]; anoikis [GO:0043276]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; establishment of vesicle localization [GO:0051650]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein-containing complex assembly [GO:0065003]; response to virus [GO:0009615]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14651848, ECO:0000269|PubMed:24586164}. Nucleus {ECO:0000269|PubMed:14651848}. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress. {ECO:0000269|PubMed:14651848}.
Q9Y6L6	reviewed	SO1B1_HUMAN	Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)	SLCO1B1 LST1 OATP1B1 OATP2 OATPC SLC21A6	Homo sapiens (Human)	691	FUNCTION: Mediates the Na(+)-independent uptake of organic anions (PubMed:10358072, PubMed:15159445, PubMed:17412826). Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine) (PubMed:10358072, PubMed:10601278, PubMed:10873595, PubMed:12568656, PubMed:15159445, PubMed:15970799, PubMed:16627748, PubMed:17412826, PubMed:12196548, PubMed:11159893, PubMed:19129463, PubMed:26979622). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop (PubMed:22232210). Involved in the clearance of endogenous and exogenous substrates from the liver (PubMed:10358072, PubMed:10601278). Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition (PubMed:26383540). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins), such as pravastatin and pitavastatin, a clinically important class of hypolipidemic drugs (PubMed:10601278, PubMed:15970799, PubMed:15159445). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drug methotrexate (PubMed:23243220). May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver (PubMed:16627748, PubMed:16624871). Shows a pH-sensitive substrate specificity towards prostaglandin E2 and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). {ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278, ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:12568656, ECO:0000269|PubMed:15159445, ECO:0000269|PubMed:15970799, ECO:0000269|PubMed:16624871, ECO:0000269|PubMed:16627748, ECO:0000269|PubMed:17412826, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:22232210, ECO:0000269|PubMed:23243220, ECO:0000269|PubMed:26383540, ECO:0000269|PubMed:26979622, ECO:0000305|PubMed:35307651}.		bile acid and bile salt transport [GO:0015721]; heme catabolic process [GO:0042167]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; xenobiotic metabolic process [GO:0006805]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349]; bile acid and bile salt transport [GO:0015721]; heme catabolic process [GO:0042167]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12196548}; Multi-pass membrane protein {ECO:0000269|PubMed:12196548}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Note=Detected in basolateral membranes of hepatocytes (PubMed:12196548). Localized to the basal membrane of Sertoli cells (PubMed:35307651). {ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:35307651}.
Q9Y6L7	reviewed	TLL2_HUMAN	Tolloid-like protein 2 (EC 3.4.24.-)	TLL2 KIAA0932	Homo sapiens (Human)	1015	FUNCTION: Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.		cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; negative regulation of skeletal muscle tissue growth [GO:0048632]; protein processing [GO:0016485]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; negative regulation of skeletal muscle tissue growth [GO:0048632]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9Y6M0	reviewed	TEST_HUMAN	Testisin (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP-1) (Serine protease 21)	PRSS21 ESP1 TEST1 UNQ266/PRO303	Homo sapiens (Human)	314	FUNCTION: Could regulate proteolytic events associated with testicular germ cell maturation.		proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Q9Y6M1	reviewed	IF2B2_HUMAN	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2)	IGF2BP2 IMP2 VICKZ2	Homo sapiens (Human)	599	FUNCTION: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:9891060}.	MISCELLANEOUS: Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.; MISCELLANEOUS: [Isoform 6]: Generated by alternative initiation at Met-69. {ECO:0000305}.	anatomical structure morphogenesis [GO:0009653]; cold-induced thermogenesis [GO:0106106]; CRD-mediated mRNA stabilization [GO:0070934]; energy homeostasis [GO:0097009]; mRNA transport [GO:0051028]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; regulation of cytokine production [GO:0001817]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]	mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182]; translation regulator activity, nucleic acid binding [GO:0090079]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182]; translation regulator activity, nucleic acid binding [GO:0090079]; anatomical structure morphogenesis [GO:0009653]; cold-induced thermogenesis [GO:0106106]; CRD-mediated mRNA stabilization [GO:0070934]; energy homeostasis [GO:0097009]; mRNA transport [GO:0051028]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; regulation of cytokine production [GO:0001817]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, P-body {ECO:0000269|PubMed:29476152}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29476152}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.
Q9Y6M4	reviewed	KC1G3_HUMAN	Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1)	CSNK1G3	Homo sapiens (Human)	447	FUNCTION: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}.		endocytosis [GO:0006897]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein modification process [GO:0036211]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; endocytosis [GO:0006897]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein modification process [GO:0036211]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cytoplasm.
Q9Y6M5	reviewed	ZNT1_HUMAN	Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1)	SLC30A1 ZNT1	Homo sapiens (Human)	507	FUNCTION: Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}.		cadmium ion transmembrane transport [GO:0070574]; calcium ion import [GO:0070509]; defense response to bacterium [GO:0042742]; detoxification of cadmium ion [GO:0071585]; detoxification of zinc ion [GO:0010312]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of calcium ion import [GO:0090281]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of zinc ion transmembrane import [GO:0071584]; zinc export across plasma membrane [GO:0140882]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; T-tubule [GO:0030315]	calcium channel inhibitor activity [GO:0019855]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; T-tubule [GO:0030315]; calcium channel inhibitor activity [GO:0019855]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826]; cadmium ion transmembrane transport [GO:0070574]; calcium ion import [GO:0070509]; defense response to bacterium [GO:0042742]; detoxification of cadmium ion [GO:0071585]; detoxification of zinc ion [GO:0010312]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of calcium ion import [GO:0090281]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of zinc ion transmembrane import [GO:0071584]; zinc export across plasma membrane [GO:0140882]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:31471319}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:32441444}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to the plasma membrane is regulated by cellular zinc status. Recruitment to the plasma membrane from an internal pool is stimulated by zinc while in absence of zinc the plasma membrane pool is endocytosed and degraded (PubMed:31471319). Localizes to the basolateral surface of enterocytes (By similarity). Localizes to zinc-containing intracellular vesicles in macrophages (PubMed:32441444). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}.
Q9Y6M7	reviewed	S4A7_HUMAN	Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7)	SLC4A7 BT NBC2 NBC2B NBC3 NBCn1 SBC2 SLC4A6	Homo sapiens (Human)	1214	FUNCTION: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10347222, PubMed:12403779, PubMed:14736710, PubMed:14578046). Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells (PubMed:35772404). {ECO:0000250|UniProtKB:Q8BTY2, ECO:0000269|PubMed:10347222, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:14578046, ECO:0000269|PubMed:14736710, ECO:0000269|PubMed:29779931, ECO:0000269|PubMed:35772404}.; FUNCTION: [Isoform 6]: Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. {ECO:0000269|PubMed:29779931}.		auditory receptor cell development [GO:0060117]; bicarbonate transport [GO:0015701]; cellular response to growth factor stimulus [GO:0071363]; phagosome acidification [GO:0090383]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]	monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]; auditory receptor cell development [GO:0060117]; bicarbonate transport [GO:0015701]; cellular response to growth factor stimulus [GO:0071363]; phagosome acidification [GO:0090383]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9R1N3}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9R1N3}; Multi-pass membrane protein {ECO:0000255}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q9R1N3}. Cell membrane {ECO:0000269|PubMed:14578046, ECO:0000269|PubMed:29779931}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity). {ECO:0000250|UniProtKB:Q9R1N3}.; SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane {ECO:0000269|PubMed:29779931}; Multi-pass membrane protein {ECO:0000255}.
Q9Y6M9	reviewed	NDUB9_HUMAN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (CI-B22) (LYR motif-containing protein 3) (NADH-ubiquinone oxidoreductase B22 subunit)	NDUFB9 LYRM3 UQOR22	Homo sapiens (Human)	179	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; sensory perception of sound [GO:0007605]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Q9Y6N1	reviewed	COX11_HUMAN	Cytochrome c oxidase assembly protein COX11, mitochondrial	COX11	Homo sapiens (Human)	276	FUNCTION: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. {ECO:0000250|UniProtKB:Q8GWR0}.		ATP biosynthetic process [GO:0006754]; intracellular monoatomic cation homeostasis [GO:0030003]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	copper ion binding [GO:0005507]; electron transfer activity [GO:0009055]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; copper ion binding [GO:0005507]; electron transfer activity [GO:0009055]; ATP biosynthetic process [GO:0006754]; intracellular monoatomic cation homeostasis [GO:0030003]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:15229189, ECO:0000269|PubMed:9878253}; Single-pass membrane protein {ECO:0000269|PubMed:9878253}; Intermembrane side {ECO:0000269|PubMed:9878253}.
Q9Y6N5	reviewed	SQOR_HUMAN	Sulfide:quinone oxidoreductase, mitochondrial (SQOR) (EC 1.8.5.8) (Sulfide dehydrogenase-like) (Sulfide quinone oxidoreductase)	SQOR SQRDL CGI-44	Homo sapiens (Human)	450	FUNCTION: Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro) (PubMed:22852582). It is believed the in vivo electron acceptor is glutathione (PubMed:25225291, PubMed:29715001). {ECO:0000269|PubMed:22852582, ECO:0000269|PubMed:25225291, ECO:0000269|PubMed:29715001, ECO:0000269|PubMed:32160317}.		sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	FAD binding [GO:0071949]; glutathione-dependent sulfide quinone oxidoreductase activity [GO:0106436]; quinone binding [GO:0048038]; sulfide:quinone oxidoreductase activity [GO:0070224]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; FAD binding [GO:0071949]; glutathione-dependent sulfide quinone oxidoreductase activity [GO:0106436]; quinone binding [GO:0048038]; sulfide:quinone oxidoreductase activity [GO:0070224]; sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q9Y6N6	reviewed	LAMC3_HUMAN	Laminin subunit gamma-3 (Laminin-12 subunit gamma) (Laminin-14 subunit gamma) (Laminin-15 subunit gamma)	LAMC3	Homo sapiens (Human)	1575	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.		astrocyte development [GO:0014002]; cell adhesion [GO:0007155]; cell morphogenesis involved in differentiation [GO:0000904]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	basement membrane [GO:0005604]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020]	structural molecule activity [GO:0005198]	basement membrane [GO:0005604]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020]; structural molecule activity [GO:0005198]; astrocyte development [GO:0014002]; cell adhesion [GO:0007155]; cell morphogenesis involved in differentiation [GO:0000904]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
Q9Y6N7	reviewed	ROBO1_HUMAN	Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1)	ROBO1 DUTT1	Homo sapiens (Human)	1651	FUNCTION: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250|UniProtKB:O89026, ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577, ECO:0000269|PubMed:26529257, ECO:0000305}.	MISCELLANEOUS: Maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line. The promoter region of ROBO1 shows complete hypermethylation of CpG sites in the BT-20 breast tumor cell lines, some primary invasive breast carcinomasa and some primary clear cell renal cell carcinomas (CC-RCC).; MISCELLANEOUS: [Isoform 2]: Incomplete. {ECO:0000305}.	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; axon midline choice point recognition [GO:0016199]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; endocardial cushion formation [GO:0003272]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of negative chemotaxis [GO:0050925]; nervous system development [GO:0007399]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of gene expression [GO:0010628]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of Notch signaling pathway involved in heart induction [GO:0035481]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; pulmonary valve morphogenesis [GO:0003184]; Roundabout signaling pathway [GO:0035385]; ventricular septum morphogenesis [GO:0060412]	axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]; LRR domain binding [GO:0030275]	axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]; LRR domain binding [GO:0030275]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; axon midline choice point recognition [GO:0016199]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; endocardial cushion formation [GO:0003272]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of negative chemotaxis [GO:0050925]; nervous system development [GO:0007399]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of gene expression [GO:0010628]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of Notch signaling pathway involved in heart induction [GO:0035481]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; pulmonary valve morphogenesis [GO:0003184]; Roundabout signaling pathway [GO:0035385]; ventricular septum morphogenesis [GO:0060412]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24560577}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:O89026}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:O55005}; Single-pass membrane protein {ECO:0000250|UniProtKB:O55005}. Note=Detected at growth cones in thalamus neurons. Detected at growth cones in thalamus neurons (By similarity). PRRG4 prevents cell surface location and both colocalize in the Endoplasmic reticulum/Golgi adjacent to the cell nucleus (By similarity). {ECO:0000250|UniProtKB:O55005, ECO:0000250|UniProtKB:O89026}.
Q9Y6N8	reviewed	CAD10_HUMAN	Cadherin-10 (T2-cadherin)	CDH10	Homo sapiens (Human)	788	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synaptic membrane adhesion [GO:0099560]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; presynaptic active zone membrane [GO:0048787]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; presynaptic active zone membrane [GO:0048787]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synaptic membrane adhesion [GO:0099560]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9Y6N9	reviewed	USH1C_HUMAN	Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein)	USH1C AIE75	Homo sapiens (Human)	552	FUNCTION: Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (PubMed:24725409, PubMed:26812018). {ECO:0000250|UniProtKB:Q9ES64, ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:26812018}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	actin filament bundle assembly [GO:0051017]; brush border assembly [GO:1904970]; equilibrioception [GO:0050957]; G2/M transition of mitotic cell cycle [GO:0000086]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell stereocilium organization [GO:0060122]; parallel actin filament bundle assembly [GO:0030046]; photoreceptor cell maintenance [GO:0045494]; protein localization to microvillus [GO:1904106]; protein-containing complex assembly [GO:0065003]; regulation of microvillus length [GO:0032532]; retinal cone cell development [GO:0046549]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	apical part of cell [GO:0045177]; brush border [GO:0005903]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microvillus [GO:0005902]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; synapse [GO:0045202]	spectrin binding [GO:0030507]	apical part of cell [GO:0045177]; brush border [GO:0005903]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microvillus [GO:0005902]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; synapse [GO:0045202]; spectrin binding [GO:0030507]; actin filament bundle assembly [GO:0051017]; brush border assembly [GO:1904970]; equilibrioception [GO:0050957]; G2/M transition of mitotic cell cycle [GO:0000086]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell stereocilium organization [GO:0060122]; parallel actin filament bundle assembly [GO:0030046]; photoreceptor cell maintenance [GO:0045494]; protein localization to microvillus [GO:1904106]; protein-containing complex assembly [GO:0065003]; regulation of microvillus length [GO:0032532]; retinal cone cell development [GO:0046549]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20142502}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19297620, ECO:0000269|PubMed:21709241}. Cell projection, microvillus {ECO:0000269|PubMed:24725409}. Note=Colocalizes with F-actin (By similarity). Detected at the tip of cochlear hair cell stereocilia (By similarity). Enriched in microvilli of the intestinal brush border (PubMed:24725409). {ECO:0000250|UniProtKB:Q9ES64, ECO:0000269|PubMed:24725409}.
Q9Y6P5	reviewed	SESN1_HUMAN	Sestrin-1 (EC 1.11.1.-) (p53-regulated protein PA26)	SESN1 PA26 SEST1	Homo sapiens (Human)	492	FUNCTION: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity). {ECO:0000250|UniProtKB:P58004, ECO:0000269|PubMed:15105503, ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:26449471}.		cellular oxidant detoxification [GO:0098869]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; reactive oxygen species metabolic process [GO:0072593]; regulation of response to reactive oxygen species [GO:1901031]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; cellular oxidant detoxification [GO:0098869]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; reactive oxygen species metabolic process [GO:0072593]; regulation of response to reactive oxygen species [GO:1901031]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9926927}. Cytoplasm {ECO:0000269|PubMed:15105503}.
Q9Y6Q1	reviewed	CAN6_HUMAN	Calpain-6 (Calpain-like protease X-linked) (Calpamodulin) (CalpM)	CAPN6 CALPM CANPX	Homo sapiens (Human)	641	FUNCTION: Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity). {ECO:0000250, ECO:0000269|PubMed:17210638}.		microtubule bundle formation [GO:0001578]; regulation of cytoskeleton organization [GO:0051493]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; spindle microtubule [GO:0005876]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; spindle microtubule [GO:0005876]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; microtubule binding [GO:0008017]; microtubule bundle formation [GO:0001578]; regulation of cytoskeleton organization [GO:0051493]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17210638}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17210638}. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.
Q9Y6Q2	reviewed	STON1_HUMAN	Stonin-1 (Stoned B-like factor)	STON1 SALF SBLF STN1	Homo sapiens (Human)	735	FUNCTION: May be involved in the endocytic machinery. {ECO:0000250}.	MISCELLANEOUS: In contrast to other members of the family, it does not contain NPF (Asn-Pro-Phe) sites and thereby does not interact with EPS15, EPS15R and ITSN1.	clathrin-dependent endocytosis [GO:0072583]; focal adhesion assembly [GO:0048041]; focal adhesion disassembly [GO:0120181]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; regulation of endocytosis [GO:0030100]; ruffle assembly [GO:0097178]; substrate-dependent cell migration [GO:0006929]; synaptic vesicle endocytosis [GO:0048488]	AP-2 adaptor complex [GO:0030122]; cell leading edge [GO:0031252]; cell projection [GO:0042995]; synaptic vesicle [GO:0008021]	clathrin adaptor activity [GO:0035615]	AP-2 adaptor complex [GO:0030122]; cell leading edge [GO:0031252]; cell projection [GO:0042995]; synaptic vesicle [GO:0008021]; clathrin adaptor activity [GO:0035615]; clathrin-dependent endocytosis [GO:0072583]; focal adhesion assembly [GO:0048041]; focal adhesion disassembly [GO:0120181]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; regulation of endocytosis [GO:0030100]; ruffle assembly [GO:0097178]; substrate-dependent cell migration [GO:0006929]; synaptic vesicle endocytosis [GO:0048488]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11381094}. Membrane {ECO:0000269|PubMed:11381094}. Note=Some fraction is membrane-associated.
Q9Y6Q5	reviewed	AP1M2_HUMAN	AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin)	AP1M2	Homo sapiens (Human)	423	FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.		basolateral protein secretion [GO:0110010]; protein targeting [GO:0006605]; vesicle targeting [GO:0006903]; vesicle-mediated transport [GO:0016192]	AP-1 adaptor complex [GO:0030121]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]	clathrin adaptor activity [GO:0035615]	AP-1 adaptor complex [GO:0030121]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]; clathrin adaptor activity [GO:0035615]; basolateral protein secretion [GO:0110010]; protein targeting [GO:0006605]; vesicle targeting [GO:0006903]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Q9Y6Q6	reviewed	TNR11_HUMAN	Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265)	TNFRSF11A RANK	Homo sapiens (Human)	616	FUNCTION: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity). {ECO:0000250|UniProtKB:O35305, ECO:0000269|PubMed:9878548}.	MISCELLANEOUS: [Isoform RANK-e5a]: Reduced ability to bind RANKL and to activate NF-kappaB as compared to isoform 1. {ECO:0000305}.	adaptive immune response [GO:0002250]; cell-cell signaling [GO:0007267]; cellular response to zinc ion starvation [GO:0034224]; circadian temperature homeostasis [GO:0060086]; lymph node development [GO:0048535]; mammary gland alveolus development [GO:0060749]; monocyte chemotaxis [GO:0002548]; multinuclear osteoclast differentiation [GO:0072674]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling [GO:0071848]; positive regulation of fever generation by positive regulation of prostaglandin secretion [GO:0071812]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; response to cytokine [GO:0034097]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]; TNFSF11-mediated signaling pathway [GO:0071847]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	cytokine binding [GO:0019955]; metal ion binding [GO:0046872]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; tumor necrosis factor receptor activity [GO:0005031]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; cytokine binding [GO:0019955]; metal ion binding [GO:0046872]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; tumor necrosis factor receptor activity [GO:0005031]; adaptive immune response [GO:0002250]; cell-cell signaling [GO:0007267]; cellular response to zinc ion starvation [GO:0034224]; circadian temperature homeostasis [GO:0060086]; lymph node development [GO:0048535]; mammary gland alveolus development [GO:0060749]; monocyte chemotaxis [GO:0002548]; multinuclear osteoclast differentiation [GO:0072674]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling [GO:0071848]; positive regulation of fever generation by positive regulation of prostaglandin secretion [GO:0071812]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; response to cytokine [GO:0034097]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]; TNFSF11-mediated signaling pathway [GO:0071847]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:23664977}; Single-pass type I membrane protein {ECO:0000269|PubMed:23664977}. Membrane raft {ECO:0000250|UniProtKB:O35305}.; SUBCELLULAR LOCATION: [Isoform RANK-e5a]: Cell membrane {ECO:0000269|PubMed:23664977}; Single-pass type I membrane protein {ECO:0000269|PubMed:23664977}.
Q9Y6Q9	reviewed	NCOA3_HUMAN	Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)	NCOA3 AIB1 BHLHE42 RAC3 TRAM1	Homo sapiens (Human)	1424	FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.	MISCELLANEOUS: NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers.	cell dedifferentiation [GO:0043697]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hormone stimulus [GO:0032870]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor transactivation [GO:0035624]; regulation of stem cell division [GO:2000035]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	disordered domain specific binding [GO:0097718]; histone acetyltransferase activity [GO:0004402]; molecular adaptor activity [GO:0060090]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; protein dimerization activity [GO:0046983]; RNA polymerase II complex binding [GO:0000993]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; disordered domain specific binding [GO:0097718]; histone acetyltransferase activity [GO:0004402]; molecular adaptor activity [GO:0060090]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; protein dimerization activity [GO:0046983]; RNA polymerase II complex binding [GO:0000993]; transcription coactivator activity [GO:0003713]; cell dedifferentiation [GO:0043697]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hormone stimulus [GO:0032870]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor transactivation [GO:0035624]; regulation of stem cell division [GO:2000035]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
Q9Y6R0	reviewed	NUMBL_HUMAN	Numb-like protein (Numb-related protein) (Numb-R)	NUMBL	Homo sapiens (Human)	609	FUNCTION: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}.		adherens junction organization [GO:0034332]; axonogenesis [GO:0007409]; cytokine-mediated signaling pathway [GO:0019221]; lateral ventricle development [GO:0021670]; nervous system development [GO:0007399]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of neurogenesis [GO:0050769]; protein metabolic process [GO:0019538]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; adherens junction organization [GO:0034332]; axonogenesis [GO:0007409]; cytokine-mediated signaling pathway [GO:0019221]; lateral ventricle development [GO:0021670]; nervous system development [GO:0007399]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of neurogenesis [GO:0050769]; protein metabolic process [GO:0019538]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS. {ECO:0000250}.
Q9Y6R1	reviewed	S4A4_HUMAN	Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1)	SLC4A4 NBC NBC1 NBCE1	Homo sapiens (Human)	1079	FUNCTION: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}.		bicarbonate transport [GO:0015701]; positive regulation of glycolytic process [GO:0045821]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]; symporter activity [GO:0015293]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]; symporter activity [GO:0015293]; bicarbonate transport [GO:0015701]; positive regulation of glycolytic process [GO:0045821]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:15273250, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:17661077}; Multi-pass membrane protein {ECO:0000269|PubMed:12534288, ECO:0000305|PubMed:29500354}. Cell membrane {ECO:0000269|PubMed:12534288, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354}; Multi-pass membrane protein {ECO:0000269|PubMed:12534288, ECO:0000305|PubMed:29500354}.
Q9Y6R4	reviewed	M3K4_HUMAN	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4)	MAP3K4 KIAA0213 MAPKKK4 MEKK4 MTK1	Homo sapiens (Human)	1608	FUNCTION: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}.		chorionic trophoblast cell differentiation [GO:0060718]; intracellular signal transduction [GO:0035556]; male germ-line sex determination [GO:0019100]; MAPK cascade [GO:0000165]; phosphorylation [GO:0016310]; placenta development [GO:0001890]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of gene expression [GO:0010468]; response to UV-C [GO:0010225]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]	ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; chorionic trophoblast cell differentiation [GO:0060718]; intracellular signal transduction [GO:0035556]; male germ-line sex determination [GO:0019100]; MAPK cascade [GO:0000165]; phosphorylation [GO:0016310]; placenta development [GO:0001890]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of gene expression [GO:0010468]; response to UV-C [GO:0010225]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}.
Q9Y6R7	reviewed	FCGBP_HUMAN	IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP)	FCGBP	Homo sapiens (Human)	5405	FUNCTION: May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa. {ECO:0000269|PubMed:9182547}.			extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]		extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9Y6R9	reviewed	CCD61_HUMAN	Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog)	CCDC61	Homo sapiens (Human)	512	FUNCTION: Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:32375023}.	MISCELLANEOUS: The N-terminal 3D structure (head domain) resembles that of NHEJ1/XLF, PAXX, SASS6 and XRCC4. {ECO:0000269|PubMed:32375023}.	cell projection organization [GO:0030030]; centriole assembly [GO:0098534]; mitotic spindle assembly [GO:0090307]	centriolar satellite [GO:0034451]; centriolar subdistal appendage [GO:0120103]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	centriolar satellite [GO:0034451]; centriolar subdistal appendage [GO:0120103]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; cell projection organization [GO:0030030]; centriole assembly [GO:0098534]; mitotic spindle assembly [GO:0090307]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:32375023}. Note=Localization at the centriolar satellite is dependent on intact microtubule network (PubMed:30354798). Localizes at the centriole subdistal appendages and proximal ends (PubMed:31789463). Localized to centrosomal/satellite-like structures with the onset of centrosome separation in early G2 (PubMed:30354798). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463}.
Q9Y6T7	reviewed	DGKB_HUMAN	Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta)	DGKB DAGK2 KIAA0718	Homo sapiens (Human)	804	FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity). {ECO:0000250|UniProtKB:P49621, ECO:0000250|UniProtKB:Q6NS52, ECO:0000269|PubMed:11719522, ECO:0000305}.; FUNCTION: [Isoform 2]: Does not associate with membranes but has a diacylglycerol kinase activity. {ECO:0000269|PubMed:11719522}.		diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289]; diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q6NS52}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NS52}. Cell membrane {ECO:0000269|PubMed:11719522}; Peripheral membrane protein {ECO:0000305|PubMed:11719522}. Cytoplasm {ECO:0000269|PubMed:11719522}. Note=Translocation to the plasma membrane is induced by phorbol esters. {ECO:0000269|PubMed:11719522}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11719522}.
Q9Y6U3	reviewed	SCIN_HUMAN	Scinderin (Adseverin)	SCIN KIAA1905	Homo sapiens (Human)	715	FUNCTION: Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009). {ECO:0000250|UniProtKB:Q28046, ECO:0000250|UniProtKB:Q5ZIV9, ECO:0000250|UniProtKB:Q60604, ECO:0000269|PubMed:11568009, ECO:0000269|PubMed:26365202, ECO:0000269|PubMed:8547642}.	MISCELLANEOUS: Scinderin comes from the latine world 'scincere', meaning 'to cut'. {ECO:0000305|PubMed:8547642}.	actin filament capping [GO:0051693]; actin filament severing [GO:0051014]; actin nucleation [GO:0045010]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; calcium-ion regulated exocytosis [GO:0017156]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of actin nucleation [GO:0051127]; positive regulation of apoptotic process [GO:0043065]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of secretion [GO:0051047]; regulation of chondrocyte differentiation [GO:0032330]; sequestering of actin monomers [GO:0042989]	actin cytoskeleton [GO:0015629]; anchoring junction [GO:0070161]; brush border [GO:0005903]; cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; podosome [GO:0002102]	1-phosphatidylinositol binding [GO:0005545]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]	actin cytoskeleton [GO:0015629]; anchoring junction [GO:0070161]; brush border [GO:0005903]; cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; podosome [GO:0002102]; 1-phosphatidylinositol binding [GO:0005545]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; actin filament capping [GO:0051693]; actin filament severing [GO:0051014]; actin nucleation [GO:0045010]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; calcium-ion regulated exocytosis [GO:0017156]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of actin nucleation [GO:0051127]; positive regulation of apoptotic process [GO:0043065]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of secretion [GO:0051047]; regulation of chondrocyte differentiation [GO:0032330]; sequestering of actin monomers [GO:0042989]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, podosome {ECO:0000250|UniProtKB:Q60604}.
Q9Y6V0	reviewed	PCLO_HUMAN	Protein piccolo (Aczonin)	PCLO ACZ KIAA0559	Homo sapiens (Human)	5142	FUNCTION: Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). {ECO:0000250|UniProtKB:Q9JKS6}.		cytoskeleton organization [GO:0007010]; insulin secretion [GO:0030073]; presynapse to nucleus signaling pathway [GO:0099526]; presynaptic active zone assembly [GO:1904071]; protein localization to synapse [GO:0035418]; regulation of exocytosis [GO:0017157]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle exocytosis [GO:0016079]	axon [GO:0030424]; cytoskeleton [GO:0005856]; cytoskeleton of presynaptic active zone [GO:0048788]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; profilin binding [GO:0005522]; structural constituent of presynaptic active zone [GO:0098882]	axon [GO:0030424]; cytoskeleton [GO:0005856]; cytoskeleton of presynaptic active zone [GO:0048788]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; profilin binding [GO:0005522]; structural constituent of presynaptic active zone [GO:0098882]; cytoskeleton organization [GO:0007010]; insulin secretion [GO:0030073]; presynapse to nucleus signaling pathway [GO:0099526]; presynaptic active zone assembly [GO:1904071]; protein localization to synapse [GO:0035418]; regulation of exocytosis [GO:0017157]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle exocytosis [GO:0016079]	SUBCELLULAR LOCATION: Presynaptic active zone {ECO:0000250|UniProtKB:Q9QYX7}. Note=Colocalizes with BSN in developing axons. {ECO:0000250|UniProtKB:Q9JKS6}.
Q9Y6W3	reviewed	CAN7_HUMAN	Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH)	CAPN7 PALBH	Homo sapiens (Human)	813	FUNCTION: Calcium-regulated non-lysosomal thiol-protease. {ECO:0000250}.		positive regulation of epithelial cell migration [GO:0010634]; proteolysis [GO:0006508]; self proteolysis [GO:0097264]	centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; MIT domain binding [GO:0090541]	centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; MIT domain binding [GO:0090541]; positive regulation of epithelial cell migration [GO:0010634]; proteolysis [GO:0006508]; self proteolysis [GO:0097264]	SUBCELLULAR LOCATION: Nucleus.
Q9Y6W5	reviewed	WASF2_HUMAN	Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2)	WASF2 WAVE2	Homo sapiens (Human)	498	FUNCTION: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}.		actin cytoskeleton organization [GO:0030036]; actin filament-based movement [GO:0030048]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; ameboidal-type cell migration [GO:0001667]; angiogenesis [GO:0001525]; endocytosis [GO:0006897]; lamellipodium assembly [GO:0030032]; lamellipodium morphogenesis [GO:0072673]; megakaryocyte development [GO:0035855]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; postsynaptic actin cytoskeleton organization [GO:0098974]; Rac protein signal transduction [GO:0016601]	actin cytoskeleton [GO:0015629]; basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; SCAR complex [GO:0031209]; synapse [GO:0045202]	actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; cadherin binding [GO:0045296]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; SH3 domain binding [GO:0017124]	actin cytoskeleton [GO:0015629]; basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; SCAR complex [GO:0031209]; synapse [GO:0045202]; actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; cadherin binding [GO:0045296]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; SH3 domain binding [GO:0017124]; actin cytoskeleton organization [GO:0030036]; actin filament-based movement [GO:0030048]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; ameboidal-type cell migration [GO:0001667]; angiogenesis [GO:0001525]; endocytosis [GO:0006897]; lamellipodium assembly [GO:0030032]; lamellipodium morphogenesis [GO:0072673]; megakaryocyte development [GO:0035855]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; postsynaptic actin cytoskeleton organization [GO:0098974]; Rac protein signal transduction [GO:0016601]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Basolateral cell membrane {ECO:0000269|PubMed:30250061}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}.
Q9Y6W6	reviewed	DUS10_HUMAN	Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5)	DUSP10 MKP5	Homo sapiens (Human)	482	FUNCTION: Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. {ECO:0000269|PubMed:10391943, ECO:0000269|PubMed:10597297, ECO:0000269|PubMed:22375048}.		dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelium regeneration [GO:1905042]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; oligodendrocyte differentiation [GO:0048709]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of adaptive immune response [GO:0002819]; regulation of brown fat cell differentiation [GO:0090335]; response to lipopolysaccharide [GO:0032496]; stress-activated MAPK cascade [GO:0051403]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	JUN kinase binding [GO:0008432]; MAP kinase phosphatase activity [GO:0033549]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; mitogen-activated protein kinase p38 binding [GO:0048273]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine/threonine phosphatase activity [GO:0008330]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; JUN kinase binding [GO:0008432]; MAP kinase phosphatase activity [GO:0033549]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; mitogen-activated protein kinase p38 binding [GO:0048273]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine/threonine phosphatase activity [GO:0008330]; dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelium regeneration [GO:1905042]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; oligodendrocyte differentiation [GO:0048709]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of adaptive immune response [GO:0002819]; regulation of brown fat cell differentiation [GO:0090335]; response to lipopolysaccharide [GO:0032496]; stress-activated MAPK cascade [GO:0051403]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
Q9Y6W8	reviewed	ICOS_HUMAN	Inducible T-cell costimulator (Activation-inducible lymphocyte immunomediatory molecule) (CD antigen CD278)	ICOS AILIM	Homo sapiens (Human)	199	FUNCTION: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.		cell-cell adhesion [GO:0098609]; immune response [GO:0006955]; T cell costimulation [GO:0031295]; T cell tolerance induction [GO:0002517]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; cell-cell adhesion [GO:0098609]; immune response [GO:0006955]; T cell costimulation [GO:0031295]; T cell tolerance induction [GO:0002517]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q9Y6X0	reviewed	SETBP_HUMAN	SET-binding protein (SEB)	SETBP1 KIAA0437	Homo sapiens (Human)	1596			regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800]	cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11231286}.
Q9Y6X1	reviewed	SERP1_HUMAN	Stress-associated endoplasmic reticulum protein 1 (Ribosome-attached membrane protein 4)	SERP1 RAMP4	Homo sapiens (Human)	66	FUNCTION: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity). {ECO:0000250}.		endoplasmic reticulum unfolded protein response [GO:0030968]; glucose metabolic process [GO:0006006]; insulin secretion [GO:0030073]; muscle organ morphogenesis [GO:0048644]; plasma membrane organization [GO:0007009]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of insulin secretion [GO:0032024]; positive regulation of organ growth [GO:0046622]; positive regulation of translation [GO:0045727]; post-embryonic development [GO:0009791]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]; skeletal system development [GO:0001501]	cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ribosome [GO:0005840]		cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ribosome [GO:0005840]; endoplasmic reticulum unfolded protein response [GO:0030968]; glucose metabolic process [GO:0006006]; insulin secretion [GO:0030073]; muscle organ morphogenesis [GO:0048644]; plasma membrane organization [GO:0007009]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of insulin secretion [GO:0032024]; positive regulation of organ growth [GO:0046622]; positive regulation of translation [GO:0045727]; post-embryonic development [GO:0009791]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Q9Y6X2	reviewed	PIAS3_HUMAN	E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)	PIAS3	Homo sapiens (Human)	628	FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376). {ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:9388184}.		negative regulation of gene expression [GO:0010629]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925]; regulation of transcription by RNA polymerase II [GO:0006357]; TNFSF11-mediated signaling pathway [GO:0071847]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925]; regulation of transcription by RNA polymerase II [GO:0006357]; TNFSF11-mediated signaling pathway [GO:0071847]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54714}. Nucleus {ECO:0000250|UniProtKB:O54714}. Nucleus speckle {ECO:0000250|UniProtKB:O54714}. Note=Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. {ECO:0000250|UniProtKB:O54714}.
Q9Y6X3	reviewed	SCC4_HUMAN	MAU2 chromatid cohesion factor homolog (MAU-2) (Cohesin loading complex subunit SCC4 homolog)	MAU2 KIAA0892 SCC4	Homo sapiens (Human)	613	FUNCTION: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:28167679, PubMed:22628566). Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16802858, PubMed:16682347). {ECO:0000269|PubMed:16682347, ECO:0000269|PubMed:16802858, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679}.		cell division [GO:0051301]; chromosome segregation [GO:0007059]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; mitotic sister chromatid cohesion [GO:0007064]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Scc2-Scc4 cohesin loading complex [GO:0090694]; SMC loading complex [GO:0032116]	cohesin loader activity [GO:0061775]; double-stranded DNA binding [GO:0003690]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Scc2-Scc4 cohesin loading complex [GO:0090694]; SMC loading complex [GO:0032116]; cohesin loader activity [GO:0061775]; double-stranded DNA binding [GO:0003690]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; mitotic sister chromatid cohesion [GO:0007064]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:16682347, ECO:0000269|PubMed:16802858}. Nucleus {ECO:0000269|PubMed:28167679}. Chromosome {ECO:0000250|UniProtKB:Q9D2X5}. Note=Binds to chromatin from the end of mitosis until prophase.
Q9Y6X5	reviewed	ENPP4_HUMAN	Bis(5'-adenosyl)-triphosphatase ENPP4 (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 4) (E-NPP 4) (NPP-4)	ENPP4 KIAA0879 NPP4	Homo sapiens (Human)	453	FUNCTION: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. {ECO:0000269|PubMed:22995898, ECO:0000269|PubMed:24338010}.		blood coagulation [GO:0007596]; positive regulation of blood coagulation [GO:0030194]; purine ribonucleoside catabolic process [GO:0046130]	extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]	bis(5'-adenosyl)-triphosphatase activity [GO:0047710]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; bis(5'-adenosyl)-triphosphatase activity [GO:0047710]; metal ion binding [GO:0046872]; blood coagulation [GO:0007596]; positive regulation of blood coagulation [GO:0030194]; purine ribonucleoside catabolic process [GO:0046130]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22995898}; Single-pass type I membrane protein {ECO:0000269|PubMed:22995898}.
Q9Y6X6	reviewed	MYO16_HUMAN	Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16)	MYO16 KIAA0865 MYO16B NYAP3	Homo sapiens (Human)	1858	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). {ECO:0000250}.		cerebellum development [GO:0021549]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]	cytoplasm [GO:0005737]; myosin complex [GO:0016459]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]; protein phosphatase binding [GO:0019903]	cytoplasm [GO:0005737]; myosin complex [GO:0016459]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]; protein phosphatase binding [GO:0019903]; cerebellum development [GO:0021549]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ERC1}. Note=Found in puncta in soma and processes of astrocytes and dissociated cerebellar cells with the morphology of migrating granule cells. {ECO:0000250|UniProtKB:Q9ERC1}.
Q9Y6X8	reviewed	ZHX2_HUMAN	Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2)	ZHX2 AFR1 KIAA0854 RAF	Homo sapiens (Human)	837	FUNCTION: Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). {ECO:0000250|UniProtKB:Q8C0C0, ECO:0000269|PubMed:12741956}.		mRNA catabolic process [GO:0006402]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal bipolar neuron differentiation [GO:0060040]; somatic stem cell population maintenance [GO:0035019]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; mRNA catabolic process [GO:0006402]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal bipolar neuron differentiation [GO:0060040]; somatic stem cell population maintenance [GO:0035019]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12741956, ECO:0000269|PubMed:17056598}. Note=Colocalizes with EFNB1 intracellular domain in the nucleus. {ECO:0000250|UniProtKB:Q8C0C0}.
Q9Y6X9	reviewed	MORC2_HUMAN	ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1)	MORC2 KIAA0852 ZCWCC1	Homo sapiens (Human)	1032	FUNCTION: Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20225202, PubMed:20110259). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755, ECO:0000269|PubMed:32693025}.		chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; fatty acid metabolic process [GO:0006631]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; fatty acid metabolic process [GO:0006631]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:28581500}. Cytoplasm, cytosol {ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:24286864}. Chromosome {ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:28581500}. Nucleus matrix {ECO:0000269|PubMed:23260667}. Note=Mainly located in the nucleus (PubMed:20225202). Upon phosphorylation at Ser-739, recruited to damaged chromatin (PubMed:23260667). {ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667}.
Q9Y6Y0	reviewed	NS1BP_HUMAN	Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39)	IVNS1ABP ARA3 FLARA3 KIAA0850 KLHL39 NS1 NS1BP HSPC068	Homo sapiens (Human)	642	FUNCTION: Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). {ECO:0000250|UniProtKB:Q920Q8, ECO:0000269|PubMed:16582008, ECO:0000269|PubMed:25619834, ECO:0000269|PubMed:9696811}.; FUNCTION: (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein. {ECO:0000269|PubMed:23825951, ECO:0000269|PubMed:9696811}.		intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of protein ubiquitination [GO:0031397]; response to virus [GO:0009615]; RNA splicing [GO:0008380]; transcription by RNA polymerase III [GO:0006383]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; transcription regulator complex [GO:0005667]		cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; transcription regulator complex [GO:0005667]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of protein ubiquitination [GO:0031397]; response to virus [GO:0009615]; RNA splicing [GO:0008380]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9696811}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9696811}. Nucleus, nucleoplasm {ECO:0000269|PubMed:9696811}. Note=Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing (PubMed:9696811). Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm (PubMed:9696811). {ECO:0000250|UniProtKB:Q920Q8, ECO:0000269|PubMed:9696811}.
Q9Y6Y1	reviewed	CMTA1_HUMAN	Calmodulin-binding transcription activator 1	CAMTA1 KIAA0833 MSTP023	Homo sapiens (Human)	1673	FUNCTION: Transcriptional activator. {ECO:0000269|PubMed:11925432}.	MISCELLANEOUS: A very small segment of 1p36 located within CAMTA1 is deleted in all oligodendroglial tumors with 1p LOH. This minimal deleted region (MDR) also overlaps the neuroblastoma 1p36 MDR. CAMTA1 shows no evidence of inactivation by somatic mutations.	neuromuscular process controlling balance [GO:0050885]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]	double-stranded DNA binding [GO:0003690]; sequence-specific DNA binding [GO:0043565]; transcription coregulator activity [GO:0003712]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; double-stranded DNA binding [GO:0003690]; sequence-specific DNA binding [GO:0043565]; transcription coregulator activity [GO:0003712]; neuromuscular process controlling balance [GO:0050885]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:11925432}. Cytoplasm {ECO:0000305|PubMed:15138581}.
Q9Y6Y8	reviewed	S23IP_HUMAN	SEC23-interacting protein (p125)	SEC23IP MSTP053	Homo sapiens (Human)	1000	FUNCTION: Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum {ECO:0000305}.
Q9Y6Y9	reviewed	LY96_HUMAN	Lymphocyte antigen 96 (Ly-96) (ESOP-1) (Protein MD-2)	LY96 ESOP1 MD2	Homo sapiens (Human)	160	FUNCTION: Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581). {ECO:0000269|PubMed:10359581, ECO:0000269|PubMed:11160242, ECO:0000269|PubMed:11593030, ECO:0000269|PubMed:17569869, ECO:0000269|PubMed:17803912}.		cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; detection of lipopolysaccharide [GO:0032497]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of tumor necrosis factor production [GO:0032760]; response to lipopolysaccharide [GO:0032496]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]	endosome membrane [GO:0010008]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lipopolysaccharide receptor complex [GO:0046696]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	coreceptor activity [GO:0015026]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; Toll-like receptor 4 binding [GO:0035662]	endosome membrane [GO:0010008]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lipopolysaccharide receptor complex [GO:0046696]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; coreceptor activity [GO:0015026]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; Toll-like receptor 4 binding [GO:0035662]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; detection of lipopolysaccharide [GO:0032497]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of tumor necrosis factor production [GO:0032760]; response to lipopolysaccharide [GO:0032496]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:10359581, ECO:0000269|PubMed:11593030, ECO:0000305|PubMed:11274165}. Secreted {ECO:0000269|PubMed:11593030}. Note=Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581). {ECO:0000269|PubMed:10359581, ECO:0000269|PubMed:11593030}.
Q9Y6Z7	reviewed	COL10_HUMAN	Collectin-10 (Collectin liver protein 1) (CL-L1) (Collectin-34) (CL-34)	COLEC10 CLL1 UNQ366/PRO702	Homo sapiens (Human)	277	FUNCTION: Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine (PubMed:10224141). Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481). {ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.		cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; cranial skeletal system development [GO:1904888]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]	collagen trimer [GO:0005581]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; multivesicular body [GO:0005771]; serine-type endopeptidase complex [GO:1905370]	chemoattractant activity [GO:0042056]; mannose binding [GO:0005537]	collagen trimer [GO:0005581]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; multivesicular body [GO:0005771]; serine-type endopeptidase complex [GO:1905370]; chemoattractant activity [GO:0042056]; mannose binding [GO:0005537]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; cranial skeletal system development [GO:1904888]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28301481}. Golgi apparatus {ECO:0000250|UniProtKB:Q8CF98}. Cytoplasm {ECO:0000269|PubMed:10224141}.
A0A024RBG1	reviewed	NUD4B_HUMAN	Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (DIPP-2B) (EC 3.6.1.52) (Nucleoside diphosphate-linked moiety X motif 4B) (Nudix motif 4B) (Nudix hydrolase 4B)	NUDT4B	Homo sapiens (Human)	181	FUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000250|UniProtKB:Q9NZJ9}.		adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NZJ9}.
A0A075B6N1	reviewed	TVB19_HUMAN	T cell receptor beta variable 19	TRBV19	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	alpha-beta T cell receptor complex [GO:0042105]; plasma membrane [GO:0005886]		alpha-beta T cell receptor complex [GO:0042105]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A087WT01	reviewed	TVA27_HUMAN	T cell receptor alpha variable 27	TRAV27	Homo sapiens (Human)	109	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; response to bacterium [GO:0009617]	alpha-beta T cell receptor complex [GO:0042105]		alpha-beta T cell receptor complex [GO:0042105]; adaptive immune response [GO:0002250]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0K0K1A5	reviewed	TVB65_HUMAN	T cell receptor beta variable 6-5	TRBV6-5	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000269|PubMed:26875526, ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A1B0GTB2	reviewed	TUNAR_HUMAN	Protein TUNAR (pTUNAR) (Beta cell and neural cell-regulin) (BNLN) (TCL1 upstream neural differentiation-associated RNA)	TUNAR	Homo sapiens (Human)	48	FUNCTION: In neurons, plays a role in the regulation of intracellular Ca(2+), possibly by acting as an activator of ATP2A2/SERCA2, thus increasing the efficiency with which Ca(2+) is removed from the cytoplasm (By similarity). Inhibits differentiation of embryonic stem cells into neurons and inhibits neurite outgrowth, likely as a result of its role in intracellular Ca(2+) regulation (By similarity). In pancreatic beta cells, lowers Ca(2+) levels in the endoplasmic reticulum and enhances glucose-stimulated insulin secretion (PubMed:34513312). {ECO:0000250|UniProtKB:A0A1B0GQX2, ECO:0000269|PubMed:34513312}.		endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of neuron differentiation [GO:0045665]; neuron projection morphogenesis [GO:0048812]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; regulation of cytosolic calcium ion concentration [GO:0051480]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	ATPase binding [GO:0051117]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ATPase binding [GO:0051117]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of neuron differentiation [GO:0045665]; neuron projection morphogenesis [GO:0048812]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; regulation of cytosolic calcium ion concentration [GO:0051480]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:34513312}; Single-pass membrane protein {ECO:0000255}. Extracellular vesicle membrane {ECO:0000250|UniProtKB:A0A1B0GQX2}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GTQ4	reviewed	MYMX_HUMAN	Protein myomixer (Microprotein inducer of fusion) (Protein minion) (hMINION)	MYMX	Homo sapiens (Human)	84	FUNCTION: Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:28569745, PubMed:35642635). Involved in membrane fusion downstream of the lipid mixing step mediated by MYMK (By similarity). Acts by generating membrane stresses via its extracellular C-terminus, leading to drive fusion pore formation. Acts independently of MYMK (By similarity). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (By similarity). {ECO:0000250|UniProtKB:Q2Q5T5, ECO:0000269|PubMed:28569745, ECO:0000269|PubMed:35642635}.		myoblast fusion [GO:0007520]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; plasma membrane fusion [GO:0045026]; skeletal muscle organ development [GO:0060538]; skeletal muscle tissue regeneration [GO:0043403]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]		endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; myoblast fusion [GO:0007520]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; plasma membrane fusion [GO:0045026]; skeletal muscle organ development [GO:0060538]; skeletal muscle tissue regeneration [GO:0043403]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2Q5T5}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q2Q5T5}.
A0A1B0GVQ0	reviewed	SPAR_HUMAN	Small regulatory polypeptide of amino acid response	SPAAR LINC00961 SPAR	Homo sapiens (Human)	90	FUNCTION: [Isoform 2]: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity). {ECO:0000250|UniProtKB:A0A1B0GSZ0, ECO:0000269|PubMed:28024296}.		cellular response to amino acid stimulus [GO:0071230]; negative regulation of TORC1 signaling [GO:1904262]; regulation of skeletal muscle tissue regeneration [GO:0043416]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]		late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; cellular response to amino acid stimulus [GO:0071230]; negative regulation of TORC1 signaling [GO:1904262]; regulation of skeletal muscle tissue regeneration [GO:0043416]	SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:28024296}; Single-pass membrane protein {ECO:0000305|PubMed:28024296}. Lysosome membrane {ECO:0000269|PubMed:28024296}; Single-pass membrane protein {ECO:0000305|PubMed:28024296}.
A0A5B9	reviewed	TRBC2_HUMAN	T cell receptor beta constant 2	TRBC2 TCRBC2	Homo sapiens (Human)	178	FUNCTION: Constant region of T cell receptor (TR) beta chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; T cell receptor signaling pathway [GO:0050852]	alpha-beta T cell receptor complex [GO:0042105]; plasma membrane [GO:0005886]		alpha-beta T cell receptor complex [GO:0042105]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A7P0TBJ1	reviewed	HAPR2_HUMAN	HUWE1-associated protein modifying stress responses 2	HAPSTR2	Homo sapiens (Human)	273	FUNCTION: Together with HAPSTR1 plays a central regulatory role in the cellular response to molecular stressors, such as DNA damage, nutrient scarcity, and protein misfolding (PubMed:36631436). Regulates these multiple stress response signaling pathways by stabilizing HAPSTR1, but also independently of HAPSTR1 (PubMed:36631436). {ECO:0000269|PubMed:36631436}.		protein stabilization [GO:0050821]	nucleus [GO:0005634]	ubiquitin protein ligase binding [GO:0031625]	nucleus [GO:0005634]; ubiquitin protein ligase binding [GO:0031625]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:36631436}.
A0A8I5KQE6	reviewed	RPSA2_HUMAN	Small ribosomal subunit protein uS2B (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (40S ribosomal protein SA2) (67 kDa laminin receptor) (67LR) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40)	RPSA2 RPSA RPSAP58	Homo sapiens (Human)	295	FUNCTION: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016}.	MISCELLANEOUS: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. {ECO:0000255|HAMAP-Rule:MF_03016}.	ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]	cytosolic small ribosomal subunit [GO:0022627]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	laminin binding [GO:0043236]; laminin receptor activity [GO:0005055]; structural constituent of ribosome [GO:0003735]	cytosolic small ribosomal subunit [GO:0022627]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; laminin binding [GO:0043236]; laminin receptor activity [GO:0005055]; structural constituent of ribosome [GO:0003735]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_03016}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03016}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane. {ECO:0000255|HAMAP-Rule:MF_03016}.
A0PJW6	reviewed	TM223_HUMAN	Transmembrane protein 223	TMEM223	Homo sapiens (Human)	202	FUNCTION: Mitochondrial ribosome-associated protein involved in the first steps of cytochrome c oxidase complex (complex IV) biogenesis (PubMed:34969438). Stimulates the translation of MT-CO1 mRNA and is a constituent of early MT-CO1 assembly intermediates (PubMed:34969438). {ECO:0000269|PubMed:34969438}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]; nervous system development [GO:0007399]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	mitochondrial ribosome binding [GO:0097177]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; mitochondrial ribosome binding [GO:0097177]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:34969438}; Multi-pass membrane protein {ECO:0000255}.
A0PJW8	reviewed	DAPL1_HUMAN	Death-associated protein-like 1 (Early epithelial differentiation-associated protein)	DAPL1 EEDA	Homo sapiens (Human)	107	FUNCTION: May play a role in the early stages of epithelial differentiation or in apoptosis. {ECO:0000250}.		apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; cellular response to amino acid starvation [GO:0034198]; negative regulation of autophagy [GO:0010507]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; ribosome hibernation [GO:0141014]		death domain binding [GO:0070513]; ribosome binding [GO:0043022]; translation initiation factor binding [GO:0031369]; translation repressor activity [GO:0030371]	death domain binding [GO:0070513]; ribosome binding [GO:0043022]; translation initiation factor binding [GO:0031369]; translation repressor activity [GO:0030371]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; cellular response to amino acid starvation [GO:0034198]; negative regulation of autophagy [GO:0010507]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; ribosome hibernation [GO:0141014]	
A0PJX0	reviewed	CIB4_HUMAN	Calcium and integrin-binding family member 4	CIB4	Homo sapiens (Human)	185		MISCELLANEOUS: The binding of either calcium or magnesium may significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).			calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]	calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]	
A0PJZ3	reviewed	GXLT2_HUMAN	Glucoside xylosyltransferase 2 (EC 2.4.2.42) (Glycosyltransferase 8 domain-containing protein 4)	GXYLT2 GLT8D4	Homo sapiens (Human)	443	FUNCTION: Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose. {ECO:0000269|PubMed:19940119}.		O-glycan processing [GO:0016266]	membrane [GO:0016020]	UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity [GO:0140563]; UDP-xylosyltransferase activity [GO:0035252]	membrane [GO:0016020]; UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity [GO:0140563]; UDP-xylosyltransferase activity [GO:0035252]; O-glycan processing [GO:0016266]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
A0PK05	reviewed	TMM72_HUMAN	Transmembrane protein 72 (Kidney-specific secretory protein of 37 kDa)	TMEM72 C10orf127 KSP37	Homo sapiens (Human)	275				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A1A5D9	reviewed	BICL2_HUMAN	BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B)	BICDL2 BICDR2 CCDC64B	Homo sapiens (Human)	508			Golgi to secretory granule transport [GO:0055107]; vesicle transport along microtubule [GO:0047496]	cytoplasm [GO:0005737]	small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; small GTPase binding [GO:0031267]; Golgi to secretory granule transport [GO:0055107]; vesicle transport along microtubule [GO:0047496]	
A1L020	reviewed	MEX3A_HUMAN	RNA-binding protein MEX3A (RING finger and KH domain-containing protein 4)	MEX3A RKHD4	Homo sapiens (Human)	520	FUNCTION: RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.			cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17267406}. Nucleus {ECO:0000269|PubMed:17267406}. Cytoplasm, P-body {ECO:0000269|PubMed:17267406}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.
A1L188	reviewed	NDUF8_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8	NDUFAF8 C17orf89	Homo sapiens (Human)	74	FUNCTION: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) (PubMed:27499296). Required to stabilize NDUFAF5 (PubMed:27499296). {ECO:0000269|PubMed:27499296}.		mitochondrial respiratory chain complex I assembly [GO:0032981]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; mitochondrial respiratory chain complex I assembly [GO:0032981]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:27499296}.
A1YPR0	reviewed	ZBT7C_HUMAN	Zinc finger and BTB domain-containing protein 7C (Affected by papillomavirus DNA integration in ME180 cells protein 1) (APM-1) (Zinc finger and BTB domain-containing protein 36) (Zinc finger protein 857C)	ZBTB7C APM1 ZBTB36 ZNF857C	Homo sapiens (Human)	619	FUNCTION: May be a tumor suppressor gene. {ECO:0000269|PubMed:9427755}.		negative regulation of cell population proliferation [GO:0008285]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	
A2A2V5	reviewed	SRTM1_HUMAN	Serine-rich and transmembrane domain-containing protein 1	SERTM1 C13orf36	Homo sapiens (Human)	107				intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]		intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A2A3K4	reviewed	PTPC1_HUMAN	Protein tyrosine phosphatase domain-containing protein 1 (EC 3.1.3.-)	PTPDC1 PTP9Q22	Homo sapiens (Human)	754	FUNCTION: May play roles in cilia formation and/or maintenance. {ECO:0000250}.		cilium assembly [GO:0060271]; dephosphorylation [GO:0016311]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cilium assembly [GO:0060271]; dephosphorylation [GO:0016311]	
A2RRD8	reviewed	ZN320_HUMAN	Zinc finger protein 320	ZNF320	Homo sapiens (Human)	509	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A2RUS2	reviewed	DEND3_HUMAN	DENN domain-containing protein 3	DENND3 KIAA0870	Homo sapiens (Human)	1198	FUNCTION: Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). {ECO:0000250|UniProtKB:A2RT67, ECO:0000269|PubMed:20937701}.		endosome to lysosome transport [GO:0008333]; protein catabolic process [GO:0030163]; regulation of Rab protein signal transduction [GO:0032483]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; guanyl-nucleotide exchange factor activity [GO:0005085]; endosome to lysosome transport [GO:0008333]; protein catabolic process [GO:0030163]; regulation of Rab protein signal transduction [GO:0032483]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2RT67}. Note=Transiently recruited to membranes to activate RAB12. {ECO:0000250|UniProtKB:A2RT67}.
A2VDF0	reviewed	FUCM_HUMAN	Fucose mutarotase (EC 5.1.3.29)	FUOM C10orf125	Homo sapiens (Human)	154	FUNCTION: Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. {ECO:0000269|PubMed:17602138}.		fucose metabolic process [GO:0006004]; fucosylation [GO:0036065]	cytosol [GO:0005829]	fucose binding [GO:0042806]; L-fucose mutarotase activity [GO:0036373]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]	cytosol [GO:0005829]; fucose binding [GO:0042806]; L-fucose mutarotase activity [GO:0036373]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]; fucose metabolic process [GO:0006004]; fucosylation [GO:0036065]	
A3KN83	reviewed	SBNO1_HUMAN	Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3)	SBNO1 MOP3	Homo sapiens (Human)	1393			regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	chromatin DNA binding [GO:0031490]; histone binding [GO:0042393]	nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; histone binding [GO:0042393]; regulation of DNA-templated transcription [GO:0006355]	
A4D1S5	reviewed	RAB19_HUMAN	Ras-related protein Rab-19	RAB19 RAB19B	Homo sapiens (Human)	217			autophagosome assembly [GO:0000045]; intracellular protein transport [GO:0006886]	endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagosome assembly [GO:0000045]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
A4FU01	reviewed	MTMRB_HUMAN	Myotubularin-related protein 11 (Cisplatin resistance-associated protein) (hCRA) (Inactive phosphatidylinositol 3-phosphatase 11)	MTMR11	Homo sapiens (Human)	709		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]		cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	
A4FU49	reviewed	SH321_HUMAN	SH3 domain-containing protein 21	SH3D21 C1orf113	Homo sapiens (Human)	640		MISCELLANEOUS: [Isoform 1]: Gene prediction based on EST data and similarity to mouse and macaca fascicularis orthologs.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	actin filament organization [GO:0007015]; cell migration [GO:0016477]	nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; actin filament organization [GO:0007015]; cell migration [GO:0016477]	
A4FU69	reviewed	EFCB5_HUMAN	EF-hand calcium-binding domain-containing protein 5	EFCAB5	Homo sapiens (Human)	1503					calcium ion binding [GO:0005509]	calcium ion binding [GO:0005509]	
A5D6W6	reviewed	FITM1_HUMAN	Fat storage-inducing transmembrane protein 1 (Fat-inducing protein 1)	FITM1 FIT1	Homo sapiens (Human)	292	FUNCTION: Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:18160536) (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol (By similarity). {ECO:0000255|HAMAP-Rule:MF_03229, ECO:0000269|PubMed:18160536}.		lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; phospholipid biosynthetic process [GO:0008654]; positive regulation of sequestering of triglyceride [GO:0010890]	endoplasmic reticulum membrane [GO:0005789]	acyl-coenzyme A diphosphatase activity [GO:0106399]; diacylglycerol binding [GO:0019992]; triglyceride binding [GO:0017129]	endoplasmic reticulum membrane [GO:0005789]; acyl-coenzyme A diphosphatase activity [GO:0106399]; diacylglycerol binding [GO:0019992]; triglyceride binding [GO:0017129]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; phospholipid biosynthetic process [GO:0008654]; positive regulation of sequestering of triglyceride [GO:0010890]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03229, ECO:0000269|PubMed:18160536}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03229}.
A5PLN9	reviewed	TPC13_HUMAN	Trafficking protein particle complex subunit 13	TRAPPC13 C5orf44	Homo sapiens (Human)	417		MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	
A6NC51	reviewed	T150B_HUMAN	Modulator of macroautophagy TMEM150B (Protein DRAM-3) (Transmembrane protein 150B) (Transmembrane protein 224)	TMEM150B TMEM224	Homo sapiens (Human)	233	FUNCTION: Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859). {ECO:0000269|PubMed:25929859}.		autophagy [GO:0006914]	autophagosome membrane [GO:0000421]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]		autophagosome membrane [GO:0000421]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; autophagy [GO:0006914]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:25929859}; Multi-pass membrane protein {ECO:0000269|PubMed:25608530}. Endosome membrane {ECO:0000269|PubMed:25929859}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:25929859}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes mainly at the plasma membrane where it concentrates at actin-rich focal adhesions (PubMed:25608530, PubMed:25929859). {ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:25929859}.
A6NCE7	reviewed	MP3B2_HUMAN	Microtubule-associated proteins 1A/1B light chain 3 beta 2 (Microtubule-associated proteins 1A/1B light chain 3B-like)	MAP1LC3B2	Homo sapiens (Human)	125	FUNCTION: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000250|UniProtKB:Q9GZQ8}.		autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; macroautophagy [GO:0016236]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]	microtubule binding [GO:0008017]; ubiquitin protein ligase binding [GO:0031625]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; microtubule binding [GO:0008017]; ubiquitin protein ligase binding [GO:0031625]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; macroautophagy [GO:0016236]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q9GZQ8}; Lipid-anchor {ECO:0000250|UniProtKB:Q9GZQ8}. Endomembrane system {ECO:0000250|UniProtKB:Q9GZQ8}; Lipid-anchor {ECO:0000250|UniProtKB:Q9GZQ8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9CQV6}.
A6NCW0	reviewed	U17L3_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 3) (Ubiquitin thioesterase 17-like protein 3) (Ubiquitin-specific-processing protease 17-like protein 3)	USP17L3 USP17B USP17F	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		apoptotic process [GO:0006915]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; apoptotic process [GO:0006915]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
A6ND48	reviewed	O14I1_HUMAN	Olfactory receptor 14I1 (Olfactory receptor 5BU1)	OR14I1 OR5BU1 OR5BU1P	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NDA9	reviewed	LRIT2_HUMAN	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 (Leucine-rich repeat-containing protein 22)	LRIT2 LRRC22	Homo sapiens (Human)	550				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
A6NDP7	reviewed	MADL2_HUMAN	Myeloid-associated differentiation marker-like protein 2	MYADML2	Homo sapiens (Human)	307				cytoplasm [GO:0005737]; membrane [GO:0016020]		cytoplasm [GO:0005737]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NDU8	reviewed	RIMC1_HUMAN	RAB7A-interacting MON1-CCZ1 complex subunit 1 (UPF0600 protein C5orf51)	RIMOC1 C5orf51	Homo sapiens (Human)	294	FUNCTION: Plays an important role in the removal of damaged mitochondria via mitophagy by controlling the stability and localization of RAB7A. Required for the recruitment of RAB7A and ATG9A vesicles to damaged mitochondria and promotes the stability of RAB7A by inhibiting its proteasomal degradation during mitophagy. {ECO:0000269|PubMed:34432599}.		mitophagy [GO:0000423]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; mitophagy [GO:0000423]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:34432599}.
A6NEQ0	reviewed	RBY1E_HUMAN	RNA-binding motif protein, Y chromosome, family 1 member E	RBMY1E	Homo sapiens (Human)	496	FUNCTION: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.	MISCELLANEOUS: The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.	mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus.
A6NF83	reviewed	NUPR2_HUMAN	Nuclear protein 2 (Nuclear transcriptional regulator 1-like protein) (Nuclear transcriptional regulator protein 2)	NUPR2 NUPR1L	Homo sapiens (Human)	97	FUNCTION: Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells (PubMed:25899918). Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation (PubMed:25899918). Plays a role as a negative regulator of the protumoral factor NUPR1 (PubMed:25899918). {ECO:0000269|PubMed:25899918}.		cell cycle [GO:0007049]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]		nucleus [GO:0005634]; cell cycle [GO:0007049]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25899918}.
A6NFD8	reviewed	HELT_HUMAN	Hairy and enhancer of split-related protein HELT (HES/HEY-like transcription factor)	HELT	Homo sapiens (Human)	242	FUNCTION: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. {ECO:0000250}.		anterior/posterior pattern specification [GO:0009952]; central nervous system development [GO:0007417]; GABAergic neuron differentiation in basal ganglia [GO:0021858]; multicellular organism growth [GO:0035264]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; suckling behavior [GO:0001967]; transcription by RNA polymerase II [GO:0006366]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anterior/posterior pattern specification [GO:0009952]; central nervous system development [GO:0007417]; GABAergic neuron differentiation in basal ganglia [GO:0021858]; multicellular organism growth [GO:0035264]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; suckling behavior [GO:0001967]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
A6NFK2	reviewed	GRCR2_HUMAN	Glutaredoxin domain-containing cysteine-rich protein 2 (GRXCR1-like protein) (Glutaredoxin domain-containing cysteine-rich protein 1-like protein)	GRXCR2	Homo sapiens (Human)	248	FUNCTION: Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection. {ECO:0000269|PubMed:24619944}.		auditory receptor cell stereocilium organization [GO:0060088]; protein localization to organelle [GO:0033365]; sensory perception of sound [GO:0007605]	microvillus [GO:0005902]; stereocilium base [GO:0120044]; stereocilium shaft [GO:0120043]		microvillus [GO:0005902]; stereocilium base [GO:0120044]; stereocilium shaft [GO:0120043]; auditory receptor cell stereocilium organization [GO:0060088]; protein localization to organelle [GO:0033365]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000250}.
A6NFN3	reviewed	RFOX3_HUMAN	RNA binding protein fox-1 homolog 3 (Fox-1 homolog C) (Neuronal nuclei antigen) (NeuN antigen)	RBFOX3	Homo sapiens (Human)	312	FUNCTION: Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). {ECO:0000250|UniProtKB:Q8BIF2}.		mRNA processing [GO:0006397]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; mRNA processing [GO:0006397]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24215932}. Cytoplasm {ECO:0000269|PubMed:24215932}. Note=Largely restricted to neuronal nuclei. However, significant cytoplasmic localization in neurons from brains from HIV-infected individuals with cognitive impairment. {ECO:0000269|PubMed:24215932}.
A6NFR6	reviewed	CE060_HUMAN	Uncharacterized protein C5orf60	C5orf60	Homo sapiens (Human)	353				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A6NGB9	reviewed	WIPF3_HUMAN	WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog)	WIPF3 CR16	Homo sapiens (Human)	483	FUNCTION: May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity). {ECO:0000250}.		Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell differentiation [GO:0030154]; endocytic recycling [GO:0032456]; exocytosis [GO:0006887]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; WASH complex [GO:0071203]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]	cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; WASH complex [GO:0071203]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell differentiation [GO:0030154]; endocytic recycling [GO:0032456]; exocytosis [GO:0006887]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm. Note=In hippocampal neurons colocalizes with WASL in the cell body, axons and the growth cone. {ECO:0000250}.
A6NGC4	reviewed	TLCD2_HUMAN	TLC domain-containing protein 2	TLCD2	Homo sapiens (Human)	264	FUNCTION: Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349). {ECO:0000269|PubMed:30509349}.		membrane assembly [GO:0071709]; phospholipid homeostasis [GO:0055091]; plasma membrane organization [GO:0007009]; regulation of membrane lipid distribution [GO:0097035]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; membrane assembly [GO:0071709]; phospholipid homeostasis [GO:0055091]; plasma membrane organization [GO:0007009]; regulation of membrane lipid distribution [GO:0097035]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:30509349}; Multi-pass membrane protein {ECO:0000305}.
A6NGY5	reviewed	O51F1_HUMAN	Olfactory receptor 51F1	OR51F1 OR51F1P	Homo sapiens (Human)	319	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NH00	reviewed	OR2T8_HUMAN	Olfactory receptor 2T8	OR2T8 OR2T8P	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NHC0	reviewed	CAN8_HUMAN	Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain)	CAPN8 NCL2	Homo sapiens (Human)	703	FUNCTION: Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity). {ECO:0000250}.		proteolysis [GO:0006508]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}.
A6NHN0	reviewed	OTOL1_HUMAN	Otolin-1	OTOL1	Homo sapiens (Human)	477	FUNCTION: Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OC90, modulates calcite crystal morphology and growth kinetics. {ECO:0000250|UniProtKB:Q4ZJM7}.		extracellular matrix organization [GO:0030198]; otolith mineralization [GO:0045299]; protein homooligomerization [GO:0051260]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; extracellular matrix organization [GO:0030198]; otolith mineralization [GO:0045299]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q4ZJM7}. Note=Localized in both the surrounding otoconial matrix and otoconia. {ECO:0000250|UniProtKB:Q4ZJM7}.
A6NHQ2	reviewed	FBLL1_HUMAN	rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 (EC 2.1.1.-) (Protein-glutamine methyltransferase)	FBLL1	Homo sapiens (Human)	334	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). {ECO:0000250}.		blastocyst hatching [GO:0001835]; box C/D RNA 3'-end processing [GO:0000494]; rRNA methylation [GO:0031167]	box C/D RNP complex [GO:0031428]; Cajal body [GO:0015030]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	histone H2AQ104 methyltransferase activity [GO:1990259]; RNA binding [GO:0003723]; rRNA methyltransferase activity [GO:0008649]	box C/D RNP complex [GO:0031428]; Cajal body [GO:0015030]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; histone H2AQ104 methyltransferase activity [GO:1990259]; RNA binding [GO:0003723]; rRNA methyltransferase activity [GO:0008649]; blastocyst hatching [GO:0001835]; box C/D RNA 3'-end processing [GO:0000494]; rRNA methylation [GO:0031167]	SUBCELLULAR LOCATION: Nucleus, nucleolus. Note=Fibrillar region of the nucleolus. {ECO:0000250}.
A6NHQ4	reviewed	EPOP_HUMAN	Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28)	EPOP C17orf96 PRR28	Homo sapiens (Human)	379	FUNCTION: Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. {ECO:0000250|UniProtKB:Q7TNS8}.		neuron fate commitment [GO:0048663]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]	chromosome [GO:0005694]; elongin complex [GO:0070449]; ESC/E(Z) complex [GO:0035098]	chromatin binding [GO:0003682]; protein-containing complex binding [GO:0044877]	chromosome [GO:0005694]; elongin complex [GO:0070449]; ESC/E(Z) complex [GO:0035098]; chromatin binding [GO:0003682]; protein-containing complex binding [GO:0044877]; neuron fate commitment [GO:0048663]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7TNS8}. Chromosome {ECO:0000250|UniProtKB:Q7TNS8}. Note=Localizes at both PRC2/EZH2 sites (H3K27me3) and broad H3K4me3 sites on chromatin of embryonic stem cells (ESCs). {ECO:0000250|UniProtKB:Q7TNS8}.
A6NHT5	reviewed	HMX3_HUMAN	Homeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx-5.1)	HMX3 NKX-5.1 NKX5-1	Homo sapiens (Human)	357	FUNCTION: Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity). {ECO:0000250}.		brain development [GO:0007420]; cell differentiation [GO:0030154]; embryo implantation [GO:0007566]; inner ear morphogenesis [GO:0042472]; maternal process involved in female pregnancy [GO:0060135]; neuromuscular process controlling balance [GO:0050885]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; brain development [GO:0007420]; cell differentiation [GO:0030154]; embryo implantation [GO:0007566]; inner ear morphogenesis [GO:0042472]; maternal process involved in female pregnancy [GO:0060135]; neuromuscular process controlling balance [GO:0050885]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A6NI28	reviewed	RHG42_HUMAN	Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42)	ARHGAP42 GRAF3 TMEM133	Homo sapiens (Human)	874	FUNCTION: May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}.		activation of GTPase activity [GO:0090630]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; GTPase activator activity [GO:0005096]; activation of GTPase activity [GO:0090630]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; signal transduction [GO:0007165]	
A6NI79	reviewed	CCD69_HUMAN	Coiled-coil domain-containing protein 69	CCDC69	Homo sapiens (Human)	296	FUNCTION: May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone. {ECO:0000305|PubMed:20962590}.		spindle midzone assembly [GO:0051255]	cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle midzone [GO:0051233]	microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle midzone [GO:0051233]; microtubule binding [GO:0008017]; spindle midzone assembly [GO:0051255]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20962590}. Midbody {ECO:0000269|PubMed:20962590}. Note=During early anaphase, localizes along overlapping interpolar microtubules between the separating chromosomes. During late anaphase, localizes to the center of spindle midzone. Concentrated at the midbody during telophase. {ECO:0000269|PubMed:20962590}.
A6NJB7	reviewed	PRR19_HUMAN	Proline-rich protein 19	PRR19	Homo sapiens (Human)	356	FUNCTION: Promotes meiotic crossing over formation through its interaction with CNTD1 by participating in the crossover differentiation step of crossover-specific recombination intermediates. {ECO:0000250|UniProtKB:B2RW88}.		meiotic cell cycle [GO:0051321]	chromosome [GO:0005694]; nucleus [GO:0005634]		chromosome [GO:0005694]; nucleus [GO:0005634]; meiotic cell cycle [GO:0051321]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B2RW88}. Chromosome {ECO:0000250|UniProtKB:B2RW88}. Note=Co-localized at crossover sites with CNTD1. Localizes on synapsed chromosome only in mid/late pachytene spermatocytes. {ECO:0000250|UniProtKB:B2RW88}.
A6NJT0	reviewed	UNC4_HUMAN	Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1)	UNCX UNCX4.1	Homo sapiens (Human)	531	FUNCTION: Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity). {ECO:0000250}.		cartilage condensation [GO:0001502]; common myeloid progenitor cell proliferation [GO:0035726]; dorsal spinal cord development [GO:0021516]; olfactory bulb interneuron differentiation [GO:0021889]; pattern specification process [GO:0007389]; regulation of cell differentiation [GO:0045595]; regulation of gene expression [GO:0010468]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; cartilage condensation [GO:0001502]; common myeloid progenitor cell proliferation [GO:0035726]; dorsal spinal cord development [GO:0021516]; olfactory bulb interneuron differentiation [GO:0021889]; pattern specification process [GO:0007389]; regulation of cell differentiation [GO:0045595]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A6NK97	reviewed	S22AK_HUMAN	Solute carrier family 22 member 20 (Organic anion transporter 6) (Solute carrier family 22 member 20 pseudogene)	SLC22A20P OAT6 SLC22A20	Homo sapiens (Human)	555	FUNCTION: Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter (By similarity). {ECO:0000250}.		monoatomic ion transport [GO:0006811]	membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]; monoatomic ion transport [GO:0006811]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NKF1	reviewed	SAC31_HUMAN	SAC3 domain-containing protein 1 (SAC3 homology domain-containing protein 1)	SAC3D1 SHD1	Homo sapiens (Human)	404	FUNCTION: Involved in centrosome duplication and mitotic progression. {ECO:0000250}.		cell division [GO:0051301]; centrosome duplication [GO:0051298]; spindle assembly [GO:0051225]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; cell division [GO:0051301]; centrosome duplication [GO:0051298]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes on centrosomes in interphase cells and at spindles in mitosis. {ECO:0000250}.
A6NL88	reviewed	SHSA7_HUMAN	Protein shisa-7 (Cystine-knot AMPAR modulating protein of 59 kDa) (CKAMP59) (GABA(A) receptor auxiliary subunit Shisa7) (Protein shisa-6-like)	SHISA7	Homo sapiens (Human)	538	FUNCTION: Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses. {ECO:0000250|UniProtKB:Q8C3Q5}.		gamma-aminobutyric acid receptor clustering [GO:0097112]; gamma-aminobutyric acid signaling pathway [GO:0007214]; memory [GO:0007613]; positive regulation of long-term synaptic potentiation [GO:1900273]; regulation of GABA-A receptor activity [GO:0106040]; regulation of short-term neuronal synaptic plasticity [GO:0048172]	AMPA glutamate receptor complex [GO:0032281]; dendritic spine membrane [GO:0032591]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]	GABA receptor binding [GO:0050811]	AMPA glutamate receptor complex [GO:0032281]; dendritic spine membrane [GO:0032591]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; GABA receptor binding [GO:0050811]; gamma-aminobutyric acid receptor clustering [GO:0097112]; gamma-aminobutyric acid signaling pathway [GO:0007214]; memory [GO:0007613]; positive regulation of long-term synaptic potentiation [GO:1900273]; regulation of GABA-A receptor activity [GO:0106040]; regulation of short-term neuronal synaptic plasticity [GO:0048172]	SUBCELLULAR LOCATION: Postsynaptic density membrane {ECO:0000250|UniProtKB:Q8C3Q5}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8C3Q5}. Note=Localizes at GABAergic inhibitory synapses and colocalizes with gephyrin in hippocampal neurons. {ECO:0000250|UniProtKB:Q8C3Q5}.
A6NLJ0	reviewed	C2C4B_HUMAN	C2 calcium-dependent domain-containing protein 4B (Nuclear-localized factor 2) (Protein FAM148B)	C2CD4B FAM148B NLF2	Homo sapiens (Human)	364	FUNCTION: May be involved in inflammatory process. May regulate cell architecture and adhesion. {ECO:0000269|PubMed:15527968}.		positive regulation of acute inflammatory response [GO:0002675]; regulation of cell adhesion [GO:0030155]; regulation of vascular permeability involved in acute inflammatory response [GO:0002528]	nucleus [GO:0005634]		nucleus [GO:0005634]; positive regulation of acute inflammatory response [GO:0002675]; regulation of cell adhesion [GO:0030155]; regulation of vascular permeability involved in acute inflammatory response [GO:0002528]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15527968}.
A6NLU0	reviewed	RFPLA_HUMAN	Ret finger protein-like 4A (RING finger protein 210)	RFPL4A RFPL4 RNF210	Homo sapiens (Human)	287			innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8VH31}. Nucleus {ECO:0000250|UniProtKB:Q8VH31}.
A6NLX3	reviewed	SPDE4_HUMAN	Speedy protein E4	SPDYE4	Homo sapiens (Human)	237					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
A6NMB1	reviewed	SIG16_HUMAN	Sialic acid-binding Ig-like lectin 16 (Siglec-16) (Siglec-P16)	SIGLEC16 SIGLECP16	Homo sapiens (Human)	481	FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. {ECO:0000250}.		cell adhesion [GO:0007155]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of interleukin-6 production [GO:0032755]	plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]	plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; cell adhesion [GO:0007155]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of interleukin-6 production [GO:0032755]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:18629938}; Single-pass type I membrane protein {ECO:0000269|PubMed:18629938}.
A6NMN3	reviewed	F170B_HUMAN	Protein FAM170B (Acrosome-related protein)	FAM170B C10orf73	Homo sapiens (Human)	283	FUNCTION: Plays a role in fertilization through the acrosome reaction. {ECO:0000250|UniProtKB:E9PXT9}.		fertilization [GO:0009566]; positive regulation of acrosome reaction [GO:2000344]; regulation of fertilization [GO:0080154]	acrosomal vesicle [GO:0001669]; outer acrosomal membrane [GO:0002081]		acrosomal vesicle [GO:0001669]; outer acrosomal membrane [GO:0002081]; fertilization [GO:0009566]; positive regulation of acrosome reaction [GO:2000344]; regulation of fertilization [GO:0080154]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:26179146}. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000250|UniProtKB:E9PXT9}.
A6NNA5	reviewed	DRGX_HUMAN	Dorsal root ganglia homeobox protein (Paired-related homeobox protein-like 1)	DRGX PRRXL1	Homo sapiens (Human)	263	FUNCTION: Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain. {ECO:0000250}.		axon guidance [GO:0007411]; detection of chemical stimulus [GO:0009593]; detection of temperature stimulus [GO:0016048]; dorsal spinal cord development [GO:0021516]; neuron migration [GO:0001764]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of mechanical stimulus [GO:0050954]; trigeminal nerve development [GO:0021559]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; axon guidance [GO:0007411]; detection of chemical stimulus [GO:0009593]; detection of temperature stimulus [GO:0016048]; dorsal spinal cord development [GO:0021516]; neuron migration [GO:0001764]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of mechanical stimulus [GO:0050954]; trigeminal nerve development [GO:0021559]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
A6NND4	reviewed	O2AT4_HUMAN	Olfactory receptor 2AT4 (Olfactory receptor OR11-265)	OR2AT4	Homo sapiens (Human)	320	FUNCTION: Olfactory receptor (PubMed:24999593, PubMed:30228264). Activated by the synthetic sandalwood odorant sandalore (PubMed:24999593, PubMed:30228264). Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs (PubMed:24999593, PubMed:30228264). Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes (PubMed:24999593). Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases (PubMed:30228264). {ECO:0000269|PubMed:24999593, ECO:0000269|PubMed:30228264, ECO:0000305}.		positive regulation of ERK1 and ERK2 cascade [GO:0070374]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24999593}; Multi-pass membrane protein {ECO:0000255}.
A6NNE9	reviewed	MARHB_HUMAN	E3 ubiquitin-protein ligase MARCHF11 (EC 2.3.2.27) (Membrane-associated RING finger protein 11) (Membrane-associated RING-CH protein XI) (MARCH-XI) (RING-type E3 ubiquitin transferase MARCHF11)	MARCHF11 MARCH11	Homo sapiens (Human)	402	FUNCTION: E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids. {ECO:0000250|UniProtKB:A6P320}.		protein ubiquitination [GO:0016567]	cytoplasmic vesicle membrane [GO:0030659]	ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasmic vesicle membrane [GO:0030659]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:A6P320}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A6P320}.
A6NNS2	reviewed	DRS7C_HUMAN	Dehydrogenase/reductase SDR family member 7C (EC 1.1.1.105) (Sarcoplasmic reticulum protein of 35 kDa) (Protein SRP-35) (Short-chain dehydrogenase/reductase family 32C member 2) (Protein SDR32C2)	DHRS7C SDR32C2	Homo sapiens (Human)	312	FUNCTION: NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal. Plays a role in the regulation of cardiac and skeletal muscle metabolic functions. Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal. Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes. Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid. {ECO:0000250|UniProtKB:Q8CHS7}.		glucose import [GO:0046323]; intracellular calcium ion homeostasis [GO:0006874]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	longitudinal sarcoplasmic reticulum [GO:0014801]; sarcoplasmic reticulum membrane [GO:0033017]	NAD-retinol dehydrogenase activity [GO:0004745]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	longitudinal sarcoplasmic reticulum [GO:0014801]; sarcoplasmic reticulum membrane [GO:0033017]; NAD-retinol dehydrogenase activity [GO:0004745]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; glucose import [GO:0046323]; intracellular calcium ion homeostasis [GO:0006874]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8CHS7}. Note=The N-terminus region encompasses a short hydrophobic sequence bound to the sarcoplasmic reticulum membrane, whereas the C-terminus catalytic domain faces the myoplasm. In skeletal muscle, enriched in the longitudinal sarcoplasmic reticulum. {ECO:0000250|UniProtKB:Q8CHS7}.
A6NNW6	reviewed	ENO4_HUMAN	Enolase 4 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase)	ENO4 C10orf134	Homo sapiens (Human)	625	FUNCTION: May be required for sperm motility and function. {ECO:0000250|UniProtKB:Q8C042}.		cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; glycolytic process [GO:0006096]	phosphopyruvate hydratase complex [GO:0000015]; sperm principal piece [GO:0097228]	magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]	phosphopyruvate hydratase complex [GO:0000015]; sperm principal piece [GO:0097228]; magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]; cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; glycolytic process [GO:0006096]	
A6QL63	reviewed	ABTB3_HUMAN	Ankyrin repeat and BTB/POZ domain-containing protein 3 (BTB/POZ domain-containing protein 11)	ABTB3 BTBD11	Homo sapiens (Human)	1104			SMAD protein signal transduction [GO:0060395]	membrane [GO:0016020]	protein heterodimerization activity [GO:0046982]	membrane [GO:0016020]; protein heterodimerization activity [GO:0046982]; SMAD protein signal transduction [GO:0060395]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
A6XGL0	reviewed	YJEN3_HUMAN	YjeF N-terminal domain-containing protein 3 (YjeF_N3) (hYjeF_N3) (ApoA-I-binding protein 2)	YJEFN3 AIBP2	Homo sapiens (Human)	299	FUNCTION: May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence (By similarity). May play a role in spermiogenesis and oogenesis (PubMed:17533573). {ECO:0000250|UniProtKB:Q1LVI2, ECO:0000269|PubMed:17533573}.		hematopoietic stem cell proliferation [GO:0071425]; lipid transport [GO:0006869]; membrane raft distribution [GO:0031580]; negative regulation of angiogenesis [GO:0016525]; regulation of cholesterol efflux [GO:0010874]; regulation of Notch signaling pathway [GO:0008593]; sprouting angiogenesis [GO:0002040]		NADHX epimerase activity [GO:0052856]	NADHX epimerase activity [GO:0052856]; hematopoietic stem cell proliferation [GO:0071425]; lipid transport [GO:0006869]; membrane raft distribution [GO:0031580]; negative regulation of angiogenesis [GO:0016525]; regulation of cholesterol efflux [GO:0010874]; regulation of Notch signaling pathway [GO:0008593]; sprouting angiogenesis [GO:0002040]	
A6ZKI3	reviewed	RTL8C_HUMAN	Retrotransposon Gag-like protein 8C (Mammalian retrotransposon derived protein 8C)	RTL8C CXX1 FAM127A MAR8 MAR8C MART8	Homo sapiens (Human)	113		MISCELLANEOUS: RTL8C is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. {ECO:0000269|PubMed:16093683}.					
A7E2F4	reviewed	GOG8A_HUMAN	Golgin subfamily A member 8A (88 kDa Golgi matrix protein) (GM88) (GM88 autoantigen)	GOLGA8A KIAA0855	Homo sapiens (Human)	631	FUNCTION: May be involved in maintaining Golgi structure. {ECO:0000250}.		Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
A7MBM2	reviewed	DISP2_HUMAN	Protein dispatched homolog 2	DISP2 C15orf36 DISPB KIAA1742 LINC00594	Homo sapiens (Human)	1401			smoothened signaling pathway [GO:0007224]	membrane [GO:0016020]; plasma membrane [GO:0005886]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A8K855	reviewed	EFCB7_HUMAN	EF-hand calcium-binding domain-containing protein 7	EFCAB7 KIAA1799	Homo sapiens (Human)	629	FUNCTION: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. {ECO:0000250|UniProtKB:Q8VDY4}.		positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to ciliary membrane [GO:1903569]; positive regulation of transcription by RNA polymerase II [GO:0045944]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasmic side of plasma membrane [GO:0009898]; plasma membrane protein complex [GO:0098797]	calcium ion binding [GO:0005509]	ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasmic side of plasma membrane [GO:0009898]; plasma membrane protein complex [GO:0098797]; calcium ion binding [GO:0005509]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to ciliary membrane [GO:1903569]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q8VDY4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VDY4}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8VDY4}. Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner. {ECO:0000250|UniProtKB:Q8VDY4}.
A8K979	reviewed	ERI2_HUMAN	ERI1 exoribonuclease 2 (EC 3.1.-.-) (Exonuclease domain-containing protein 1)	ERI2 EXOD1 KIAA1504	Homo sapiens (Human)	691			exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]		3'-5'-RNA exonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	3'-5'-RNA exonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]	
A8MPP1	reviewed	D11L8_HUMAN	Putative ATP-dependent RNA helicase DDX11-like protein 8 (EC 3.6.4.13) (DEAD/H box protein 11-like 8)	DDX11L8	Homo sapiens (Human)	907	FUNCTION: Putative DNA helicase. {ECO:0000250}.		DNA duplex unwinding [GO:0032508]; establishment of sister chromatid cohesion [GO:0034085]; nucleobase-containing compound metabolic process [GO:0006139]	nucleolus [GO:0005730]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	nucleolus [GO:0005730]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; DNA duplex unwinding [GO:0032508]; establishment of sister chromatid cohesion [GO:0034085]; nucleobase-containing compound metabolic process [GO:0006139]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
A8MQT2	reviewed	GOG8B_HUMAN	Golgin subfamily A member 8B (Golgin-67)	GOLGA8B	Homo sapiens (Human)	603	FUNCTION: May be involved in maintaining Golgi structure. {ECO:0000250}.	MISCELLANEOUS: Antibodies against GM88 are present in serum from a patient with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.	Golgi organization [GO:0007030]; spindle assembly [GO:0051225]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]; spindle assembly [GO:0051225]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:10677249}; Peripheral membrane protein {ECO:0000269|PubMed:10677249}.
A8MUK1	reviewed	U17L5_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 5) (Ubiquitin thioesterase 17-like protein 5) (Ubiquitin-specific-processing protease 17-like protein 5)	USP17L5	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		apoptotic process [GO:0006915]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; apoptotic process [GO:0006915]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
A8MV81	reviewed	HIG1C_HUMAN	HIG1 domain family member 1C	HIGD1C UBIE UBIE2	Homo sapiens (Human)	97			mitochondrial respirasome assembly [GO:0097250]	membrane [GO:0016020]; mitochondrion [GO:0005739]		membrane [GO:0016020]; mitochondrion [GO:0005739]; mitochondrial respirasome assembly [GO:0097250]	SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00836}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00836}.
A8MWX3	reviewed	WASH4_HUMAN	Putative WAS protein family homolog 4 (Protein FAM39CP)	WASH4P FAM39CP	Homo sapiens (Human)	477	FUNCTION: May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}.	MISCELLANEOUS: WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units. Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene. {ECO:0000305|PubMed:18159949}.	Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:A8K0Z3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8VDD8}. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2. {ECO:0000250|UniProtKB:A8K0Z3}.
A8MWY0	reviewed	ELAP2_HUMAN	Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 (Estrogen-induced gene 121-like protein) (hEIG121L)	ELAPOR2 EIG121L KIAA1324L	Homo sapiens (Human)	1029	FUNCTION: Functions as a regulator of the BMP signaling pathway and may be involved in epidermal differentiation. {ECO:0000250|UniProtKB:Q3UZV7}.		negative regulation of nervous system development [GO:0051961]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of epidermis development [GO:0045684]	plasma membrane [GO:0005886]	BMP receptor binding [GO:0070700]	plasma membrane [GO:0005886]; BMP receptor binding [GO:0070700]; negative regulation of nervous system development [GO:0051961]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of epidermis development [GO:0045684]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6DDW2}; Single-pass type I membrane protein {ECO:0000255}.
A8MXK1	reviewed	VSTM5_HUMAN	V-set and transmembrane domain-containing protein 5	VSTM5 C11orf90	Homo sapiens (Human)	200	FUNCTION: Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain. {ECO:0000250|UniProtKB:Q9D806}.		filopodium assembly [GO:0046847]; positive regulation of excitatory synapse assembly [GO:1904891]; protein homooligomerization [GO:0051260]; ventral spinal cord development [GO:0021517]	axon [GO:0030424]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]		axon [GO:0030424]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]; filopodium assembly [GO:0046847]; positive regulation of excitatory synapse assembly [GO:1904891]; protein homooligomerization [GO:0051260]; ventral spinal cord development [GO:0021517]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9D806}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9D806}. Cell projection, axon {ECO:0000250|UniProtKB:Q9D806}.
A8MYP8	reviewed	CMA1B_HUMAN	Ciliary microtubule associated protein 1B (Outer dense fiber protein 3-like protein 3) (Outer dense fiber protein 3B)	CIMAP1B ODF3B ODF3L3	Homo sapiens (Human)	253				cytoskeleton [GO:0005856]; motile cilium [GO:0031514]		cytoskeleton [GO:0005856]; motile cilium [GO:0031514]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q920N1}.
A9Z1Z3	reviewed	FR1L4_HUMAN	Fer-1-like protein 4	FER1L4 C20orf124	Homo sapiens (Human)	1794			regulation of neurotransmitter secretion [GO:0046928]	synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]	synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; regulation of neurotransmitter secretion [GO:0046928]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
B1AL88	reviewed	NALF1_HUMAN	NALCN channel auxiliary factor 1 (Transmembrane protein FAM155A)	NALF1 FAM155A NLF-1	Homo sapiens (Human)	458	FUNCTION: Auxillary component of the NALCN sodium channel complex, a channel that regulates the resting membrane potential and controls neuronal excitability. {ECO:0000269|PubMed:32494638}.		calcium ion import across plasma membrane [GO:0098703]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; calcium ion import across plasma membrane [GO:0098703]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32494638}; Multi-pass membrane protein {ECO:0000255}.
B2RNN3	reviewed	C1T9B_HUMAN	Complement C1q and tumor necrosis factor-related protein 9B (C1q/TNF-related protein 9B) (CTRP9B) (Complement C1q and tumor necrosis factor-related protein 9-like)	C1QTNF9B	Homo sapiens (Human)	333	FUNCTION: Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. {ECO:0000250|UniProtKB:Q4ZJN1}.			collagen trimer [GO:0005581]; extracellular region [GO:0005576]		collagen trimer [GO:0005581]; extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19666007}. Note=Heteromeric complex formation with CTRP9A or ADIPOQ is required for secretion, otherwise, it is retained in the endoplasmic reticulum.
B2RU33	reviewed	POTEC_HUMAN	POTE ankyrin domain family member C (ANKRD26-like family B member 2) (Prostate, ovary, testis-expressed protein on chromosome 18) (POTE-18)	POTEC A26B2 POTE18	Homo sapiens (Human)	542							
B2RXH8	reviewed	HNRC2_HUMAN	Heterogeneous nuclear ribonucleoprotein C-like 2 (hnRNP C-like-2)	HNRNPCL2 HNRNPCP5	Homo sapiens (Human)	293	FUNCTION: May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}.			nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Component of ribonucleosomes. {ECO:0000250}.
B3EWF7	reviewed	EP2A2_HUMAN	Laforin, isoform 9	EPM2A	Homo sapiens (Human)	344		MISCELLANEOUS: [Isoform 9]: Produced by alternative initiation. Arises due to the use of an alternative initiation codon in exon 1 out of frame with isoform 1 and results in a completely different isoform. {ECO:0000269|PubMed:22036712}.	negative regulation of TOR signaling [GO:0032007]; positive regulation of macroautophagy [GO:0016239]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of TOR signaling [GO:0032007]; positive regulation of macroautophagy [GO:0016239]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22036712}.
B3EWG5	reviewed	FM25C_HUMAN	Protein FAM25C	FAM25C	Homo sapiens (Human)	89							
B4DS77	reviewed	SHSA9_HUMAN	Protein shisa-9	SHISA9	Homo sapiens (Human)	424	FUNCTION: Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity). {ECO:0000250}.		regulation of short-term neuronal synaptic plasticity [GO:0048172]	AMPA glutamate receptor complex [GO:0032281]; dendritic spine membrane [GO:0032591]; glutamatergic synapse [GO:0098978]; ionotropic glutamate receptor complex [GO:0008328]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	PDZ domain binding [GO:0030165]	AMPA glutamate receptor complex [GO:0032281]; dendritic spine membrane [GO:0032591]; glutamatergic synapse [GO:0098978]; ionotropic glutamate receptor complex [GO:0008328]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; PDZ domain binding [GO:0030165]; regulation of short-term neuronal synaptic plasticity [GO:0048172]	SUBCELLULAR LOCATION: Cell projection, dendritic spine membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Synapse {ECO:0000250}.
B8ZZ34	reviewed	SHSA8_HUMAN	Protein shisa-8 (Shisa family member 8)	SHISA8 C22orf17	Homo sapiens (Human)	397	FUNCTION: May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses. {ECO:0000250|UniProtKB:J3QNX5}.		regulation of short-term neuronal synaptic plasticity [GO:0048172]	AMPA glutamate receptor complex [GO:0032281]; dendritic spine membrane [GO:0032591]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]		AMPA glutamate receptor complex [GO:0032281]; dendritic spine membrane [GO:0032591]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; regulation of short-term neuronal synaptic plasticity [GO:0048172]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
C0HLU2	reviewed	SEHBP_HUMAN	Transcriptional regulator SEHBP (Short ORF-encoded histone-binding protein) (ZNF689 upstream open reading frame protein)	ZNF689	Homo sapiens (Human)	46	FUNCTION: Plays a role in transcription regulation. {ECO:0000269|PubMed:33468658}.	MISCELLANEOUS: Encoded in the 5'-untranslated region (5'-UTR) of ZNF689. {ECO:0000269|PubMed:33468658}.	regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	histone binding [GO:0042393]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; histone binding [GO:0042393]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33468658}. Cytoplasm {ECO:0000269|PubMed:33468658}.
C0HM02	reviewed	PKHUO_HUMAN	PRKCH upstream open reading frame 2 (uORF2) (Protein uPEP2)	PRKCH	Homo sapiens (Human)	26	FUNCTION: Product of an upstream open reading frame (ORF) of PRKCH which regulates translation of the downstream protein kinase C eta (PKC-eta) ORF (PubMed:19797084, PubMed:34593629). Functions as a repressive element that maintains low basal levels of PKC-eta in growing cells but enhances its expression during stress conditions induced by amino acid starvation in a EIF2AK4/GCN2-dependent manner (PubMed:19797084, PubMed:34593629). In addition to its role in regulating PKC-eta translation, also inhibits the kinase activity of PKC-eta as well as other protein kinases including PRKCD, PRKCQ and PRKCE but not PRKCA, PRKCG or PRKCZ (PubMed:34593629). {ECO:0000269|PubMed:19797084, ECO:0000269|PubMed:34593629}.	MISCELLANEOUS: Suppresses proliferation and migration of cancer cells. {ECO:0000269|PubMed:34593629}.	cellular response to amino acid starvation [GO:0034198]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of translation [GO:0017148]; positive regulation of translation in response to stress [GO:0032056]		protein serine/threonine kinase binding [GO:0120283]; protein serine/threonine kinase inhibitor activity [GO:0030291]; translation regulator activity [GO:0045182]	protein serine/threonine kinase binding [GO:0120283]; protein serine/threonine kinase inhibitor activity [GO:0030291]; translation regulator activity [GO:0045182]; cellular response to amino acid starvation [GO:0034198]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of translation [GO:0017148]; positive regulation of translation in response to stress [GO:0032056]	
E9PAV3	reviewed	NACAM_HUMAN	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	NACA	Homo sapiens (Human)	2078	FUNCTION: Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}.		protein targeting to membrane [GO:0006612]	cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]	DNA binding [GO:0003677]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]; DNA binding [GO:0003677]; unfolded protein binding [GO:0051082]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P70670}. Nucleus {ECO:0000250|UniProtKB:P70670}.
E9PQX1	reviewed	TM262_HUMAN	Cation channel sperm-associated auxiliary subunit TMEM262 (Cation channel sperm-associated auxiliary subunit eta) (Transmembrane protein 262)	TMEM262 CATSPERH	Homo sapiens (Human)	116	FUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. {ECO:0000250|UniProtKB:D3Z338}.			CatSper complex [GO:0036128]; motile cilium [GO:0031514]		CatSper complex [GO:0036128]; motile cilium [GO:0031514]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D3Z338}.
G9CGD6	reviewed	CNIPF_HUMAN	CNK3/IPCEF1 fusion protein	CNK3/IPCEF1	Homo sapiens (Human)	899	FUNCTION: Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. {ECO:0000269|PubMed:22085542}.	MISCELLANEOUS: [Isoform CNK3-IPCEF1-1]: Based on a naturally occurring readthrough transcript which produces an CNK3/IPCEF1 fusion protein. {ECO:0000269|PubMed:22085542}.; MISCELLANEOUS: [Isoform CNK3-IPCEF1-2]: Based on a naturally occurring readthrough transcript which produces an CNK3/IPCEF1 fusion protein. {ECO:0000269|PubMed:22085542}.; MISCELLANEOUS: [Isoform CNK3-IPCEF1-3]: Based on a naturally occurring readthrough transcript which produces an CNK3/IPCEF1 fusion protein. Major isoform found in CaCo2-cells. {ECO:0000269|PubMed:22085542}.	positive regulation of cellular response to hepatocyte growth factor stimulus [GO:2001114]; regulation of signal transduction [GO:0009966]	cytoplasm [GO:0005737]; membrane [GO:0016020]		cytoplasm [GO:0005737]; membrane [GO:0016020]; positive regulation of cellular response to hepatocyte growth factor stimulus [GO:2001114]; regulation of signal transduction [GO:0009966]	
M5A8F1	reviewed	SUPYN_HUMAN	Suppressyn (Endogenous retrovirus group 48 member 1) (NDUFV3 antisense RNA 1) (endogenous retrovirus group Fb member 1)	ERVH48-1 C21orf105 HERV-Fb1 NDUFV3-AS1	Homo sapiens (Human)	160	FUNCTION: May play a role in trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development. May negatively regulate cell-cell fusion by interacting with SLC1A5, the probable receptor on the cell surface of the fusogenic syncytin-1/ERVW-1. {ECO:0000269|PubMed:23492904}.	MISCELLANEOUS: The human genome contains a high percentage of proviral-like elements, also called endogenous retroviruses (ERVs) that are the genomic traces of ancient infections of the germline by exogenous retroviruses. Although most of these elements are defective, some have conserved a functional envelope (env) gene, most probably diverted by the host for its benefit.	syncytium formation [GO:0006949]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; syncytium formation [GO:0006949]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23492904}. Note=Also found in cell lysates.
O00178	reviewed	GTPB1_HUMAN	GTP-binding protein 1 (G-protein 1) (GP-1) (GP1)	GTPBP1	Homo sapiens (Human)	669	FUNCTION: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). {ECO:0000250}.		GTP metabolic process [GO:0046039]; immune response [GO:0006955]; positive regulation of mRNA catabolic process [GO:0061014]; signal transduction [GO:0007165]; translational elongation [GO:0006414]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; membrane [GO:0016020]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; membrane [GO:0016020]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; GTP metabolic process [GO:0046039]; immune response [GO:0006955]; positive regulation of mRNA catabolic process [GO:0061014]; signal transduction [GO:0007165]; translational elongation [GO:0006414]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O00230	reviewed	CORT_HUMAN	Cortistatin [Cleaved into: Cortistatin-29; Cortistatin-17]	CORT UNQ307/PRO350	Homo sapiens (Human)	105	FUNCTION: Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; regulation of cell migration [GO:0030334]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; synapse [GO:0045202]	G protein-coupled receptor binding [GO:0001664]; neuropeptide hormone activity [GO:0005184]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; synapse [GO:0045202]; G protein-coupled receptor binding [GO:0001664]; neuropeptide hormone activity [GO:0005184]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; regulation of cell migration [GO:0030334]	SUBCELLULAR LOCATION: Secreted.
O00295	reviewed	TULP2_HUMAN	Tubby-related protein 2 (Cancer/testis antigen 65) (CT65) (Tubby-like protein 2)	TULP2 TUBL2	Homo sapiens (Human)	520			protein localization to cilium [GO:0061512]; visual perception [GO:0007601]	cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]	protein-containing complex binding [GO:0044877]	cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; protein-containing complex binding [GO:0044877]; protein localization to cilium [GO:0061512]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway. {ECO:0000250}.
O00321	reviewed	ETV2_HUMAN	ETS translocation variant 2 (Ets-related protein 71)	ETV2 ER71 ETSRP71	Homo sapiens (Human)	342	FUNCTION: Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. {ECO:0000250}.		blastocyst development [GO:0001824]; blood vessel morphogenesis [GO:0048514]; BMP signaling pathway [GO:0030509]; erythrocyte differentiation [GO:0030218]; mesoderm formation [GO:0001707]; Notch signaling pathway [GO:0007219]; placenta development [GO:0001890]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of gene expression [GO:0010628]; positive regulation of mesoderm development [GO:2000382]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; blastocyst development [GO:0001824]; blood vessel morphogenesis [GO:0048514]; BMP signaling pathway [GO:0030509]; erythrocyte differentiation [GO:0030218]; mesoderm formation [GO:0001707]; Notch signaling pathway [GO:0007219]; placenta development [GO:0001890]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of gene expression [GO:0010628]; positive regulation of mesoderm development [GO:2000382]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus.
O00398	reviewed	P2Y10_HUMAN	Putative P2Y purinoceptor 10 (P2Y10) (P2Y-like receptor)	P2RY10	Homo sapiens (Human)	339	FUNCTION: Putative receptor for purines coupled to G-proteins.		phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O00458	reviewed	IFRD1_HUMAN	Interferon-related developmental regulator 1 (Nerve growth factor-inducible protein PC4)	IFRD1	Homo sapiens (Human)	451	FUNCTION: Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity). {ECO:0000250}.		muscle cell differentiation [GO:0042692]; myoblast fate determination [GO:0007518]; negative regulation of axon extension [GO:0030517]; negative regulation of collateral sprouting [GO:0048671]; skeletal muscle tissue regeneration [GO:0043403]; striated muscle tissue development [GO:0014706]	nucleus [GO:0005634]; sarcoplasm [GO:0016528]		nucleus [GO:0005634]; sarcoplasm [GO:0016528]; muscle cell differentiation [GO:0042692]; myoblast fate determination [GO:0007518]; negative regulation of axon extension [GO:0030517]; negative regulation of collateral sprouting [GO:0048671]; skeletal muscle tissue regeneration [GO:0043403]; striated muscle tissue development [GO:0014706]	
O00515	reviewed	LAD1_HUMAN	Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA)	LAD1 LAD	Homo sapiens (Human)	517	FUNCTION: Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}.			actin cytoskeleton [GO:0015629]; basement membrane [GO:0005604]; extracellular exosome [GO:0070062]	cadherin binding [GO:0045296]; structural molecule activity [GO:0005198]	actin cytoskeleton [GO:0015629]; basement membrane [GO:0005604]; extracellular exosome [GO:0070062]; cadherin binding [GO:0045296]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}.
O00534	reviewed	VMA5A_HUMAN	von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein)	VWA5A BCSC1 LOH11CR2A	Homo sapiens (Human)	786	FUNCTION: May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.			nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	
O00570	reviewed	SOX1_HUMAN	Transcription factor SOX-1	SOX1	Homo sapiens (Human)	391	FUNCTION: Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; forebrain neuron development [GO:0021884]; interneuron migration [GO:1904936]; lens morphogenesis in camera-type eye [GO:0002089]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of oligodendrocyte differentiation [GO:0048713]; ventral spinal cord interneuron specification [GO:0021521]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; forebrain neuron development [GO:0021884]; interneuron migration [GO:1904936]; lens morphogenesis in camera-type eye [GO:0002089]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of oligodendrocyte differentiation [GO:0048713]; ventral spinal cord interneuron specification [GO:0021521]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O14513	reviewed	NCKP5_HUMAN	Nck-associated protein 5 (NAP-5) (Peripheral clock protein)	NCKAP5 ERIH NAP5	Homo sapiens (Human)	1909			microtubule bundle formation [GO:0001578]; microtubule depolymerization [GO:0007019]	microtubule plus-end [GO:0035371]		microtubule plus-end [GO:0035371]; microtubule bundle formation [GO:0001578]; microtubule depolymerization [GO:0007019]	
O14545	reviewed	TRAD1_HUMAN	TRAF-type zinc finger domain-containing protein 1 (Protein FLN29)	TRAFD1 FLN29	Homo sapiens (Human)	582	FUNCTION: Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}.		negative regulation of innate immune response [GO:0045824]	mitochondrion [GO:0005739]	metal ion binding [GO:0046872]	mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; negative regulation of innate immune response [GO:0045824]	
O14548	reviewed	COX7R_HUMAN	Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7a-related protein) (Cytochrome c oxidase subunit VIIa-related protein) (EB1)	COX7A2L COX7AR COX7RP	Homo sapiens (Human)	114	FUNCTION: Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity). {ECO:0000250|UniProtKB:Q61387}.		mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]	mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	cytochrome-c oxidase activity [GO:0004129]	mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; cytochrome-c oxidase activity [GO:0004129]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
O14599	reviewed	VCY2_HUMAN	Testis-specific basic protein Y 2 (Basic charge, Y-linked 2) (Variably charged protein Y 2)	BPY2 BPY2A VCY2 VCY2A; BPY2B VCY2B; BPY2C VCY2C	Homo sapiens (Human)	106			single fertilization [GO:0007338]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]	HECT domain binding [GO:0032399]	nucleus [GO:0005634]; HECT domain binding [GO:0032399]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]	
O14602	reviewed	IF1AY_HUMAN	Eukaryotic translation initiation factor 1A, Y-chromosomal (eIF-1A Y isoform) (eIF1A Y isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)	EIF1AY	Homo sapiens (Human)	144	FUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. {ECO:0000250|UniProtKB:P47813}.		translational initiation [GO:0006413]	cytoplasm [GO:0005737]	translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
O14626	reviewed	GP171_HUMAN	G-protein coupled receptor 171 (G-protein coupled receptor H963)	GPR171 H963	Homo sapiens (Human)	319	FUNCTION: G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function (PubMed:34615877). {ECO:0000250|UniProtKB:Q8BG55, ECO:0000269|PubMed:34615877}.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of myeloid cell differentiation [GO:0045638]; regulation of feeding behavior [GO:0060259]; regulation of sensory perception of pain [GO:0051930]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of myeloid cell differentiation [GO:0045638]; regulation of feeding behavior [GO:0060259]; regulation of sensory perception of pain [GO:0051930]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BG55}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with GPR83 in the paraventricular nucleus. {ECO:0000250|UniProtKB:Q8BG55}.
O14668	reviewed	TMG1_HUMAN	Transmembrane gamma-carboxyglutamic acid protein 1 (Proline-rich gamma-carboxyglutamic acid protein 1) (Proline-rich Gla protein 1)	PRRG1 PRGP1 TMG1	Homo sapiens (Human)	218				extracellular space [GO:0005615]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O14709	reviewed	ZN197_HUMAN	Zinc finger protein 197 (Zinc finger protein with KRAB and SCAN domains 9) (ZnF20) (pVHL-associated KRAB domain-containing protein)	ZNF197 ZKSCAN9 ZNF166	Homo sapiens (Human)	1029	FUNCTION: May be involved in transcriptional regulation.	MISCELLANEOUS: [Isoform 2]: Negative regulator of HIF1A transactivation. {ECO:0000305}.	regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O14718	reviewed	OPSX_HUMAN	Visual pigment-like receptor peropsin	RRH	Homo sapiens (Human)	337	FUNCTION: May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.		cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; visual perception [GO:0007601]	photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]	G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]	photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
O14753	reviewed	OVOL1_HUMAN	Putative transcription factor Ovo-like 1 (hOvo1)	OVOL1	Homo sapiens (Human)	267	FUNCTION: Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity). {ECO:0000250}.		epidermal cell differentiation [GO:0009913]; germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; keratinocyte proliferation [GO:0043616]; kidney development [GO:0001822]; meiotic cell cycle phase transition [GO:0044771]; mesoderm development [GO:0007498]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of meiotic cell cycle phase transition [GO:1901994]; negative regulation of stem cell proliferation [GO:2000647]; regulation of transcription by RNA polymerase II [GO:0006357]; skin development [GO:0043588]; spermatogenesis [GO:0007283]; stem cell proliferation [GO:0072089]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; epidermal cell differentiation [GO:0009913]; germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; keratinocyte proliferation [GO:0043616]; kidney development [GO:0001822]; meiotic cell cycle phase transition [GO:0044771]; mesoderm development [GO:0007498]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of meiotic cell cycle phase transition [GO:1901994]; negative regulation of stem cell proliferation [GO:2000647]; regulation of transcription by RNA polymerase II [GO:0006357]; skin development [GO:0043588]; spermatogenesis [GO:0007283]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
O14957	reviewed	QCR10_HUMAN	Cytochrome b-c1 complex subunit 10 (Complex III subunit 10) (Complex III subunit XI) (Ubiquinol-cytochrome c reductase complex 6.4 kDa protein)	UQCR11 UQCR	Homo sapiens (Human)	56	FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability. {ECO:0000250|UniProtKB:P37299}.		cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]	electron transfer activity [GO:0009055]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; electron transfer activity [GO:0009055]; cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P37299}; Single-pass membrane protein {ECO:0000250|UniProtKB:P37299}.
O15016	reviewed	TRI66_HUMAN	Tripartite motif-containing protein 66	TRIM66 C11orf29 KIAA0298	Homo sapiens (Human)	1351	FUNCTION: May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity). {ECO:0000250|UniProtKB:Q924W6}.			nucleus [GO:0005634]	zinc ion binding [GO:0008270]	nucleus [GO:0005634]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309}. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm. {ECO:0000250|UniProtKB:Q924W6}.
O15034	reviewed	RIMB2_HUMAN	RIMS-binding protein 2 (RIM-BP2)	RIMBP2 KIAA0318 RBP2	Homo sapiens (Human)	1052	FUNCTION: Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. {ECO:0000250}.		neuromuscular synaptic transmission [GO:0007274]	plasma membrane [GO:0005886]; synapse [GO:0045202]		plasma membrane [GO:0005886]; synapse [GO:0045202]; neuromuscular synaptic transmission [GO:0007274]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Synapse {ECO:0000250}. Note=Synaptic plasma membrane. {ECO:0000250}.
O15063	reviewed	GRRE1_HUMAN	Granule associated Rac and RHOG effector protein 1 (GARRE1)	GARRE1 KIAA0355	Homo sapiens (Human)	1070	FUNCTION: Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). {ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:31871319}.		Rac protein signal transduction [GO:0016601]	cytosol [GO:0005829]; P-body [GO:0000932]	CCR4-NOT complex binding [GO:1905762]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; P-body [GO:0000932]; CCR4-NOT complex binding [GO:1905762]; small GTPase binding [GO:0031267]; Rac protein signal transduction [GO:0016601]	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000305|PubMed:29395067}.
O15069	reviewed	NACAD_HUMAN	NAC-alpha domain-containing protein 1	NACAD KIAA0363	Homo sapiens (Human)	1562	FUNCTION: May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}.		protein targeting to membrane [GO:0006612]	cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]	unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]; unfolded protein binding [GO:0051082]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
O15090	reviewed	ZN536_HUMAN	Zinc finger protein 536	ZNF536 KIAA0390	Homo sapiens (Human)	1300	FUNCTION: Transcriptional repressor that negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription (PubMed:19398580). Binds and interrupts RARA from binding to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580). Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3' (PubMed:14621294). {ECO:0000269|PubMed:14621294, ECO:0000269|PubMed:19398580}.		negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19398580}.
O15218	reviewed	GP182_HUMAN	G-protein coupled receptor 182	GPR182 ADMR	Homo sapiens (Human)	404	FUNCTION: Orphan receptor.		cell surface receptor signaling pathway [GO:0007166]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O15235	reviewed	RT12_HUMAN	Small ribosomal subunit protein uS12m (28S ribosomal protein S12, mitochondrial) (MRP-S12) (S12mt) (MT-RPS12)	MRPS12 RPMS12 RPSM12	Homo sapiens (Human)	138			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; ribosome [GO:0005840]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; ribosome [GO:0005840]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
O15321	reviewed	TM9S1_HUMAN	Transmembrane 9 superfamily member 1 (MP70 protein family member) (hMP70)	TM9SF1	Homo sapiens (Human)	606	FUNCTION: Plays an essential role in autophagy. {ECO:0000269|PubMed:19029833}.		autophagy [GO:0006914]; protein localization to membrane [GO:0072657]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]		autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; autophagy [GO:0006914]; protein localization to membrane [GO:0072657]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:19029833}; Multi-pass membrane protein {ECO:0000269|PubMed:19029833}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:19029833}; Multi-pass membrane protein {ECO:0000269|PubMed:19029833}.
O15335	reviewed	CHAD_HUMAN	Chondroadherin (Cartilage leucine-rich protein)	CHAD SLRR4A	Homo sapiens (Human)	359	FUNCTION: Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity). {ECO:0000250}.		bone development [GO:0060348]; negative regulation of bone trabecula formation [GO:1900155]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; bone development [GO:0060348]; negative regulation of bone trabecula formation [GO:1900155]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
O15370	reviewed	SOX12_HUMAN	Transcription factor SOX-12 (Protein SOX-22)	SOX12 SOX22	Homo sapiens (Human)	315	FUNCTION: Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3' (By similarity). Acts as a transcriptional activator (By similarity). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions (By similarity). Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation (By similarity). Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). {ECO:0000250|UniProtKB:Q04890}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spinal cord development [GO:0021510]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spinal cord development [GO:0021510]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:9215677}.
O15375	reviewed	MOT6_HUMAN	Monocarboxylate transporter 6 (MCT 6) (Monocarboxylate transporter 5) (MCT 5) (Solute carrier family 16 member 5)	SLC16A5 MCT5 MCT6	Homo sapiens (Human)	505	FUNCTION: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}.		monocarboxylic acid transport [GO:0015718]	membrane [GO:0016020]; plasma membrane [GO:0005886]	monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]	membrane [GO:0016020]; plasma membrane [GO:0005886]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]; monocarboxylic acid transport [GO:0015718]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O15403	reviewed	MOT7_HUMAN	Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6)	SLC16A6 MCT6 MCT7	Homo sapiens (Human)	523	FUNCTION: Monocarboxylate transporter selective for taurine. May associate with BSG/CD147 or EMB/GP70 ancillary proteins to mediate facilitative efflux or influx of taurine across the plasma membrane. The transport is pH- and sodium-independent. Rather low-affinity, is likely effective for taurine transport in tissues where taurine is present at high concentrations. {ECO:0000250|UniProtKB:Q7TMR7}.		monocarboxylic acid transport [GO:0015718]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]; taurine transmembrane transporter activity [GO:0005368]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]; taurine transmembrane transporter activity [GO:0005368]; monocarboxylic acid transport [GO:0015718]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q7TMR7}; Multi-pass membrane protein {ECO:0000255}.
O15417	reviewed	TNC18_HUMAN	Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein)	TNRC18 CAGL79 KIAA1856	Homo sapiens (Human)	2968		MISCELLANEOUS: [Isoform 2]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.		cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]	
O15539	reviewed	RGS5_HUMAN	Regulator of G-protein signaling 5 (RGS5)	RGS5	Homo sapiens (Human)	181	FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: Acts as an endogenous negative regulator of isoform 1. {ECO:0000305}.	G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:15670159}. Membrane {ECO:0000269|PubMed:15670159}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15670159}.
O43247	reviewed	CMIP4_HUMAN	Ciliary microtubule inner protein 4 (Testis-expressed protein 33)	CIMIP4 C22orf33 EAN57 TEX33	Homo sapiens (Human)	280	FUNCTION: Seems to be associated with spermiogenesis but is not essential for sperm development and male fertility. {ECO:0000250|UniProtKB:Q9D9J2}.			acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126]		acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9D9J2}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D9J2}.
O43301	reviewed	HS12A_HUMAN	Heat shock 70 kDa protein 12A	HSPA12A KIAA0417	Homo sapiens (Human)	675	FUNCTION: Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. {ECO:0000269|PubMed:30679749}.			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	ATP binding [GO:0005524]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ATP binding [GO:0005524]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8K0U4}. Nucleus {ECO:0000250|UniProtKB:Q8K0U4}.
O43345	reviewed	ZN208_HUMAN	Zinc finger protein 208 (Zinc finger protein 91-like)	ZNF208 ZNF91L	Homo sapiens (Human)	1280	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O43347	reviewed	MSI1H_HUMAN	RNA-binding protein Musashi homolog 1 (Musashi-1)	MSI1	Homo sapiens (Human)	362	FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}.		central nervous system development [GO:0007417]; epithelial cell differentiation [GO:0030855]; nervous system development [GO:0007399]; regulation of translation [GO:0006417]; response to hormone [GO:0009725]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; polysome [GO:0005844]	identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; polysome [GO:0005844]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; central nervous system development [GO:0007417]; epithelial cell differentiation [GO:0030855]; nervous system development [GO:0007399]; regulation of translation [GO:0006417]; response to hormone [GO:0009725]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q61474}. Nucleus {ECO:0000250|UniProtKB:Q61474}.
O43414	reviewed	ERI3_HUMAN	ERI1 exoribonuclease 3 (EC 3.1.-.-) (Prion interactor 1) (Prion protein-interacting protein)	ERI3 PINT1 PRNPIP PRNPIP1	Homo sapiens (Human)	337			exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]		3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]	
O43448	reviewed	KCAB3_HUMAN	Voltage-gated potassium channel subunit beta-3 (K(+) channel subunit beta-3) (Kv-beta-3)	KCNAB3 KCNA3B	Homo sapiens (Human)	404	FUNCTION: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5. {ECO:0000269|PubMed:9857044}.		potassium ion transport [GO:0006813]; regulation of potassium ion transmembrane transport [GO:1901379]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	aldo-keto reductase (NADP) activity [GO:0004033]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; aldo-keto reductase (NADP) activity [GO:0004033]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transport [GO:0006813]; regulation of potassium ion transmembrane transport [GO:1901379]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
O43555	reviewed	GON2_HUMAN	Progonadoliberin-2 (Progonadoliberin II) [Cleaved into: Gonadoliberin-2 (Gonadoliberin II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II) (Luteinizing hormone-releasing hormone II) (LH-RH II); GnRH-associated peptide 2 (GnRH-associated peptide II)]	GNRH2	Homo sapiens (Human)	120	FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.		reproduction [GO:0000003]; signal transduction [GO:0007165]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	gonadotropin hormone-releasing hormone activity [GO:0005183]; gonadotropin-releasing hormone receptor binding [GO:0031530]; hormone activity [GO:0005179]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; gonadotropin hormone-releasing hormone activity [GO:0005183]; gonadotropin-releasing hormone receptor binding [GO:0031530]; hormone activity [GO:0005179]; reproduction [GO:0000003]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
O43638	reviewed	FOXS1_HUMAN	Forkhead box protein S1 (Forkhead-like 18 protein) (Forkhead-related transcription factor 10) (FREAC-10)	FOXS1 FKHL18 FREAC10	Homo sapiens (Human)	330	FUNCTION: Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity). {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; blood vessel development [GO:0001568]; cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; neuromuscular process controlling balance [GO:0050885]; positive regulation of multicellular organism growth [GO:0040018]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; blood vessel development [GO:0001568]; cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; neuromuscular process controlling balance [GO:0050885]; positive regulation of multicellular organism growth [GO:0040018]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
O43657	reviewed	TSN6_HUMAN	Tetraspanin-6 (Tspan-6) (A15 homolog) (Putative NF-kappa-B-activating protein 321) (T245 protein) (Tetraspanin TM4-D) (Transmembrane 4 superfamily member 6)	TSPAN6 TM4SF6 UNQ767/PRO1560	Homo sapiens (Human)	245			negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	extracellular exosome [GO:0070062]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; membrane [GO:0016020]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
O43677	reviewed	NDUC1_HUMAN	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial (Complex I-KFYI) (CI-KFYI) (NADH-ubiquinone oxidoreductase KFYI subunit)	NDUFC1	Homo sapiens (Human)	76	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q02376}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q02376}; Matrix side {ECO:0000250|UniProtKB:Q02376}.
O43692	reviewed	PI15_HUMAN	Peptidase inhibitor 15 (PI-15) (25 kDa trypsin inhibitor) (p25TI) (Cysteine-rich secretory protein 8) (CRISP-8) (SugarCrisp)	PI15 CRISP8 P25TI	Homo sapiens (Human)	258	FUNCTION: Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity). {ECO:0000250|UniProtKB:Q98ST6, ECO:0000269|PubMed:8882727}.			extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	peptidase inhibitor activity [GO:0030414]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; peptidase inhibitor activity [GO:0030414]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8882727}.
O43736	reviewed	ITM2A_HUMAN	Integral membrane protein 2A (Protein E25)	ITM2A UNQ603/PRO1189	Homo sapiens (Human)	263			negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; plasma cell differentiation [GO:0002317]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	amyloid-beta binding [GO:0001540]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; amyloid-beta binding [GO:0001540]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; plasma cell differentiation [GO:0002317]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
O43812	reviewed	DUX1_HUMAN	Double homeobox protein 1	DUX1	Homo sapiens (Human)	170	FUNCTION: Probable transcription activator. Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'. {ECO:0000269|PubMed:9736770}.	MISCELLANEOUS: DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found on the short arms of all acrocentric chromosomes as well as on several other chromosomes.	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15709750, ECO:0000269|PubMed:9736770}. Note=Actively transported through the nuclear pore complex (NPC).
O43908	reviewed	NKG2F_HUMAN	NKG2-F type II integral membrane protein (NK cell receptor F) (NKG2-F-activating NK receptor)	KLRC4 NKG2F	Homo sapiens (Human)	158	FUNCTION: May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.		positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	external side of plasma membrane [GO:0009897]	transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; transmembrane signaling receptor activity [GO:0004888]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
O43930	reviewed	PRKY_HUMAN	Putative serine/threonine-protein kinase PRKY (EC 2.7.11.1)	PRKY	Homo sapiens (Human)	277			protein phosphorylation [GO:0006468]		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein phosphorylation [GO:0006468]	
O43934	reviewed	MFS11_HUMAN	UNC93-like protein MFSD11 (Major facilitator superfamily domain-containing protein 11) (Protein ET)	MFSD11 ET	Homo sapiens (Human)	449				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O60225	reviewed	SSX5_HUMAN	Protein SSX5	SSX5	Homo sapiens (Human)	188	FUNCTION: Could act as a modulator of transcription.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]		nucleus [GO:0005634]; regulation of DNA-templated transcription [GO:0006355]	
O60234	reviewed	GMFG_HUMAN	Glia maturation factor gamma (GMF-gamma)	GMFG	Homo sapiens (Human)	142			actin filament debranching [GO:0071846]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; protein phosphorylation [GO:0006468]	extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]	actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; enzyme activator activity [GO:0008047]; growth factor activity [GO:0008083]; protein kinase inhibitor activity [GO:0004860]	extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; enzyme activator activity [GO:0008047]; growth factor activity [GO:0008083]; protein kinase inhibitor activity [GO:0004860]; actin filament debranching [GO:0071846]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; protein phosphorylation [GO:0006468]	
O60245	reviewed	PCDH7_HUMAN	Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh)	PCDH7 BHPCDH	Homo sapiens (Human)	1069			cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
O60262	reviewed	GBG7_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	GNG7 GNGT7	Homo sapiens (Human)	68	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity). {ECO:0000250}.		behavioral fear response [GO:0001662]; G protein-coupled receptor signaling pathway [GO:0007186]; locomotory behavior [GO:0007626]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]	G-protein beta-subunit binding [GO:0031681]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; G-protein beta-subunit binding [GO:0031681]; behavioral fear response [GO:0001662]; G protein-coupled receptor signaling pathway [GO:0007186]; locomotory behavior [GO:0007626]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
O60279	reviewed	SUSD5_HUMAN	Sushi domain-containing protein 5	SUSD5 KIAA0527	Homo sapiens (Human)	629			cell adhesion [GO:0007155]; Notch signaling pathway [GO:0007219]	membrane [GO:0016020]	hyaluronic acid binding [GO:0005540]	membrane [GO:0016020]; hyaluronic acid binding [GO:0005540]; cell adhesion [GO:0007155]; Notch signaling pathway [GO:0007219]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
O60299	reviewed	LZTS3_HUMAN	Leucine zipper putative tumor suppressor 3 (ProSAP-interacting protein 1) (ProSAPiP1)	LZTS3 KIAA0552 PROSAPIP1	Homo sapiens (Human)	673	FUNCTION: May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses. {ECO:0000250|UniProtKB:Q8K1Q4}.		regulation of dendritic spine morphogenesis [GO:0061001]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; postsynaptic density [GO:0014069]; synapse [GO:0045202]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; postsynaptic density [GO:0014069]; synapse [GO:0045202]; regulation of dendritic spine morphogenesis [GO:0061001]	SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q8K1Q4}. Postsynaptic density {ECO:0000250|UniProtKB:Q8K1Q4}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q8K1Q4}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8K1Q4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8K1Q4}. Note=Rather found at excitatory than inhibitory synapses. {ECO:0000250|UniProtKB:Q8K1Q4}.
O60330	reviewed	PCDGC_HUMAN	Protocadherin gamma-A12 (PCDH-gamma-A12) (Cadherin-21) (Fibroblast cadherin-3)	PCDHGA12 CDH21 FIB3 KIAA0588 UNQ371/PRO707	Homo sapiens (Human)	932	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
O60412	reviewed	OR7C2_HUMAN	Olfactory receptor 7C2 (Olfactory receptor 19-18) (OR19-18) (Olfactory receptor 7C3) (Olfactory receptor OR19-22)	OR7C2 OR7C3	Homo sapiens (Human)	319	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O60422	reviewed	ONEC3_HUMAN	One cut domain family member 3 (One cut homeobox 3) (Transcription factor ONECUT-3) (OC-3)	ONECUT3	Homo sapiens (Human)	494	FUNCTION: Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity). {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00374}.
O60522	reviewed	TDRD6_HUMAN	Tudor domain-containing protein 6 (Antigen NY-CO-45) (Cancer/testis antigen 41.2) (CT41.2)	TDRD6	Homo sapiens (Human)	2096	FUNCTION: Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation (By similarity). Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein) (By similarity). {ECO:0000250|UniProtKB:F1R237, ECO:0000250|UniProtKB:P61407}.		P granule organization [GO:0030719]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186]		chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P61407}. Note=Present in chromatoid body (CB) of spermatids, also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids. Colocalizes in CB with DDX4, PIWIL1, PIWIL2, TDRD1 and TDRD7. {ECO:0000250|UniProtKB:P61407}.
O60542	reviewed	PSPN_HUMAN	Persephin (PSP)	PSPN	Homo sapiens (Human)	156	FUNCTION: Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.		central nervous system development [GO:0007417]; nervous system development [GO:0007399]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; central nervous system development [GO:0007417]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Secreted.
O60676	reviewed	CST8_HUMAN	Cystatin-8 (Cystatin-related epididymal spermatogenic protein)	CST8 CRES	Homo sapiens (Human)	142	FUNCTION: Performs a specialized role during sperm development and maturation.			cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]	cysteine-type endopeptidase inhibitor activity [GO:0004869]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; cysteine-type endopeptidase inhibitor activity [GO:0004869]	SUBCELLULAR LOCATION: Secreted.
O60765	reviewed	Z354A_HUMAN	Zinc finger protein 354A (Transcription factor 17) (TCF-17) (Zinc finger protein eZNF)	ZNF354A EZNF HKL1 TCF17	Homo sapiens (Human)	605			regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23665872}.
O60774	reviewed	FMO6_HUMAN	Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (EC 1.14.13.8) (Dimethylaniline oxidase 6) (Flavin-containing monooxygenase 6) (FMO 6)	FMO6P FMO6	Homo sapiens (Human)	539	FUNCTION: It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full-length transcripts.			endoplasmic reticulum membrane [GO:0005789]	flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	endoplasmic reticulum membrane [GO:0005789]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000255}.
O60811	reviewed	PRAM2_HUMAN	PRAME family member 2	PRAMEF2	Homo sapiens (Human)	474			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
O60925	reviewed	PFD1_HUMAN	Prefoldin subunit 1	PFDN1 PFD1	Homo sapiens (Human)	122	FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.		chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]	cytoplasm [GO:0005737]; prefoldin complex [GO:0016272]	amyloid-beta binding [GO:0001540]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; prefoldin complex [GO:0016272]; amyloid-beta binding [GO:0001540]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]	
O71037	reviewed	ENK19_HUMAN	Endogenous retrovirus group K member 19 Env polyprotein (EnvK3 protein) (Envelope polyprotein) (HERV-K(C19) envelope protein) (HERV-K_19q11 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERVK-19	Homo sapiens (Human)	699	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: ERVK-19 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.		plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.; SUBCELLULAR LOCATION: [Endogenous retrovirus group K member 19 Env polyprotein]: Virion {ECO:0000250}.
O75064	reviewed	DEN4B_HUMAN	DENN domain-containing protein 4B	DENND4B KIAA0476	Homo sapiens (Human)	1496	FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.		regulation of Rab protein signal transduction [GO:0032483]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of Rab protein signal transduction [GO:0032483]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:20937701}.
O75095	reviewed	MEGF6_HUMAN	Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3)	MEGF6 EGFL3 KIAA0815	Homo sapiens (Human)	1541				extracellular region [GO:0005576]	calcium ion binding [GO:0005509]	extracellular region [GO:0005576]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O75123	reviewed	ZN623_HUMAN	Zinc finger protein 623	ZNF623 KIAA0628	Homo sapiens (Human)	536	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O75153	reviewed	CLU_HUMAN	Clustered mitochondria protein homolog	CLUH KIAA0664	Homo sapiens (Human)	1309	FUNCTION: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. {ECO:0000255|HAMAP-Rule:MF_03013, ECO:0000269|PubMed:25349259}.		intracellular distribution of mitochondria [GO:0048312]; mitochondrion organization [GO:0007005]	cytoplasm [GO:0005737]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; mRNA binding [GO:0003729]; intracellular distribution of mitochondria [GO:0048312]; mitochondrion organization [GO:0007005]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}. Cytoplasmic granule {ECO:0000269|PubMed:25349259}. Note=A fraction colocalizes with tyrosinated tubulin and can be detected close to mitochondria. {ECO:0000269|PubMed:25349259}.
O75157	reviewed	T22D2_HUMAN	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4)	TSC22D2 KIAA0669 TILZ4	Homo sapiens (Human)	780	FUNCTION: Reduces the level of nuclear PKM isoform M2 which results in repression of cyclin CCND1 transcription and reduced cell growth. {ECO:0000269|PubMed:27573352}.	MISCELLANEOUS: May be involved in the loss of cell cycle regulation in colorectal tumors, expression is shown to be decreased in the majority of tumors. {ECO:0000269|PubMed:27573352}.	regulation of transcription by RNA polymerase II [GO:0006357]; response to osmotic stress [GO:0006970]			regulation of transcription by RNA polymerase II [GO:0006357]; response to osmotic stress [GO:0006970]	
O75310	reviewed	UDB11_HUMAN	UDP-glucuronosyltransferase 2B11 (UDPGT 2B11) (EC 2.4.1.17)	UGT2B11	Homo sapiens (Human)	529	FUNCTION: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.		cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]	endoplasmic reticulum membrane [GO:0005789]	glucuronosyltransferase activity [GO:0015020]	endoplasmic reticulum membrane [GO:0005789]; glucuronosyltransferase activity [GO:0015020]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
O75325	reviewed	LRRN2_HUMAN	Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5)	LRRN2 GAC1 LRRN5 UNQ256/PRO293	Homo sapiens (Human)	713			cell adhesion [GO:0007155]; signal transduction [GO:0007165]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]	signaling receptor activity [GO:0038023]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; signaling receptor activity [GO:0038023]; cell adhesion [GO:0007155]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O75335	reviewed	LIPA4_HUMAN	Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4)	PPFIA4 KIAA0897	Homo sapiens (Human)	1185	FUNCTION: May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity). {ECO:0000250}.		synapse organization [GO:0050808]	cell surface [GO:0009986]; cytosol [GO:0005829]; presynaptic active zone [GO:0048786]; synapse [GO:0045202]		cell surface [GO:0009986]; cytosol [GO:0005829]; presynaptic active zone [GO:0048786]; synapse [GO:0045202]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell surface {ECO:0000250}. Note=Colocalizes with PTPRF at the cell surface. {ECO:0000250}.
O75346	reviewed	ZN253_HUMAN	Zinc finger protein 253 (Bone marrow zinc finger 1) (BMZF-1) (Zinc finger protein 411)	ZNF253 BMZF1 ZNF411	Homo sapiens (Human)	499	FUNCTION: May function as a transcription factor. Seem to have a transcriptional repression activity.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O75352	reviewed	MPU1_HUMAN	Mannose-P-dolichol utilization defect 1 protein (Suppressor of Lec15 and Lec35 glycosylation mutation homolog) (SL15)	MPDU1	Homo sapiens (Human)	247	FUNCTION: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors. {ECO:0000250}.		dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide biosynthetic process [GO:0009312]; protein folding [GO:0006457]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]		endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide biosynthetic process [GO:0009312]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O75363	reviewed	BCAS1_HUMAN	Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1)	BCAS1 AIBC1 NABC1	Homo sapiens (Human)	584	FUNCTION: Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}.		myelination [GO:0042552]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]		cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; myelination [GO:0042552]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14567997}.
O75380	reviewed	NDUS6_HUMAN	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit)	NDUFS6	Homo sapiens (Human)	124	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]	electron transfer activity [GO:0009055]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; electron transfer activity [GO:0009055]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
O75388	reviewed	GPR32_HUMAN	Probable G-protein coupled receptor 32	GPR32	Homo sapiens (Human)	356	FUNCTION: Orphan receptor.		complement receptor mediated signaling pathway [GO:0002430]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	plasma membrane [GO:0005886]	complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; N-formyl peptide receptor activity [GO:0004982]	plasma membrane [GO:0005886]; complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; N-formyl peptide receptor activity [GO:0004982]; complement receptor mediated signaling pathway [GO:0002430]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O75394	reviewed	RM33_HUMAN	Large ribosomal subunit protein bL33m (39S ribosomal protein L33, mitochondrial) (L33mt) (MRP-L33)	MRPL33 C2orf1	Homo sapiens (Human)	65			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
O75437	reviewed	ZN254_HUMAN	Zinc finger protein 254 (Bone marrow zinc finger 5) (BMZF-5) (Hematopoietic cell-derived zinc finger protein 1) (HD-ZNF1) (Zinc finger protein 539) (Zinc finger protein 91-like)	ZNF254 BMZF5 ZNF539 ZNF91L	Homo sapiens (Human)	659	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O75459	reviewed	PAGE1_HUMAN	P antigen family member 1 (PAGE-1) (AL5) (G antigen 9) (GAGE-9) (G antigen family B member 1) (Prostate-associated gene 1 protein)	PAGE1 GAGE9 GAGEB1	Homo sapiens (Human)	146		MISCELLANEOUS: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
O75493	reviewed	CAH11_HUMAN	Carbonic anhydrase-related protein 11 (CA-RP XI) (CA-XI) (CARP XI) (Carbonic anhydrase-related protein 2) (CA-RP II) (CARP-2)	CA11 CARP2 UNQ211/PRO237	Homo sapiens (Human)	328	FUNCTION: Does not have a catalytic activity.		one-carbon metabolic process [GO:0006730]	basolateral plasma membrane [GO:0016323]; extracellular region [GO:0005576]	hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270]	basolateral plasma membrane [GO:0016323]; extracellular region [GO:0005576]; hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270]; one-carbon metabolic process [GO:0006730]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O75541	reviewed	ZN821_HUMAN	Zinc finger protein 821	ZNF821	Homo sapiens (Human)	412	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O75596	reviewed	CLC3A_HUMAN	C-type lectin domain family 3 member A (C-type lectin superfamily member 1) (Cartilage-derived C-type lectin)	CLEC3A CLECSF1 UNQ700/PRO1345	Homo sapiens (Human)	197	FUNCTION: Promotes cell adhesion to laminin-332 and fibronectin.		ossification [GO:0001503]; skeletal system development [GO:0001501]	extracellular space [GO:0005615]	carbohydrate binding [GO:0030246]	extracellular space [GO:0005615]; carbohydrate binding [GO:0030246]; ossification [GO:0001503]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19173304}.
O75635	reviewed	SPB7_HUMAN	Serpin B7 (Megsin) (TP55)	SERPINB7	Homo sapiens (Human)	380	FUNCTION: Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.		positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of platelet-derived growth factor production [GO:0090362]; positive regulation of transforming growth factor beta1 production [GO:0032914]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of platelet-derived growth factor production [GO:0090362]; positive regulation of transforming growth factor beta1 production [GO:0032914]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O75678	reviewed	RFPL2_HUMAN	Ret finger protein-like 2 (RING finger protein 79)	RFPL2 RNF79	Homo sapiens (Human)	378		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to intron retention. {ECO:0000305}.	innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	
O75683	reviewed	SURF6_HUMAN	Surfeit locus protein 6	SURF6 SURF-6	Homo sapiens (Human)	361	FUNCTION: Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). {ECO:0000250}.		ribosomal large subunit biogenesis [GO:0042273]; ribosomal small subunit biogenesis [GO:0042274]	chromosome [GO:0005694]; granular component [GO:0001652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; RNA binding [GO:0003723]	chromosome [GO:0005694]; granular component [GO:0001652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal small subunit biogenesis [GO:0042274]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Granular component of the nucleolus. {ECO:0000250}.
O75690	reviewed	KRA58_HUMAN	Keratin-associated protein 5-8 (Keratin, ultra high-sulfur matrix protein B) (Keratin-associated protein 5.8) (UHS keratin B) (UHS KerB) (Ultrahigh sulfur keratin-associated protein 5.8)	KRTAP5-8 KAP5.8 KRTAP5.8 UHSKB	Homo sapiens (Human)	187	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]	structural constituent of skin epidermis [GO:0030280]	cytosol [GO:0005829]; intermediate filament [GO:0005882]; structural constituent of skin epidermis [GO:0030280]	
O75711	reviewed	SCRG1_HUMAN	Scrapie-responsive protein 1 (Scrapie-responsive gene 1 protein) (ScRG-1)	SCRG1 UNQ390/PRO725	Homo sapiens (Human)	98			nervous system development [GO:0007399]	extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; neuron projection terminus [GO:0044306]		extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; neuron projection terminus [GO:0044306]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O75715	reviewed	GPX5_HUMAN	Epididymal secretory glutathione peroxidase (EC 1.11.1.9) (Epididymis-specific glutathione peroxidase-like protein) (EGLP) (Glutathione peroxidase 5) (GPx-5) (GSHPx-5)	GPX5	Homo sapiens (Human)	221	FUNCTION: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.		cellular response to oxidative stress [GO:0034599]; lipid metabolic process [GO:0006629]	extracellular region [GO:0005576]	glutathione peroxidase activity [GO:0004602]	extracellular region [GO:0005576]; glutathione peroxidase activity [GO:0004602]; cellular response to oxidative stress [GO:0034599]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Secreted.
O75764	reviewed	TCEA3_HUMAN	Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h)	TCEA3 TFIISH	Homo sapiens (Human)	348	FUNCTION: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.		DNA-templated transcription [GO:0006351]; transcription elongation by RNA polymerase II [GO:0006368]	nucleus [GO:0005634]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; DNA-templated transcription [GO:0006351]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649, ECO:0000255|PROSITE-ProRule:PRU00651}.
O75820	reviewed	ZN189_HUMAN	Zinc finger protein 189	ZNF189	Homo sapiens (Human)	626	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O75830	reviewed	SPI2_HUMAN	Serpin I2 (Myoepithelium-derived serine protease inhibitor) (Pancpin) (Pancreas-specific protein TSA2004) (Peptidase inhibitor 14) (PI-14)	SERPINI2 MEPI PI14	Homo sapiens (Human)	405				extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O75901	reviewed	RASF9_HUMAN	Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor)	RASSF9 PAMCI PCIP1	Homo sapiens (Human)	435	FUNCTION: May play a role in regulating vesicuar trafficking in cells. {ECO:0000250}.		endosomal transport [GO:0016197]; intracellular transport [GO:0046907]; protein targeting [GO:0006605]; signal transduction [GO:0007165]	cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; recycling endosome [GO:0055037]; trans-Golgi network transport vesicle membrane [GO:0012510]		cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; recycling endosome [GO:0055037]; trans-Golgi network transport vesicle membrane [GO:0012510]; endosomal transport [GO:0016197]; intracellular transport [GO:0046907]; protein targeting [GO:0006605]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Endosome. Note=Accumulates on perinuclear endosomes. {ECO:0000250}.
O75947	reviewed	ATP5H_HUMAN	ATP synthase subunit d, mitochondrial (ATPase subunit d) (ATP synthase peripheral stalk subunit d)	ATP5PD ATP5H My032	Homo sapiens (Human)	161	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.		proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, stator stalk [GO:0000274]; mitochondrion [GO:0005739]	proton transmembrane transporter activity [GO:0015078]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, stator stalk [GO:0000274]; mitochondrion [GO:0005739]; proton transmembrane transporter activity [GO:0015078]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane.
O75953	reviewed	DNJB5_HUMAN	DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-2) (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40)	DNAJB5 HSC40	Homo sapiens (Human)	348			chaperone cofactor-dependent protein refolding [GO:0051085]; response to unfolded protein [GO:0006986]	cytosol [GO:0005829]	protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	cytosol [GO:0005829]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; chaperone cofactor-dependent protein refolding [GO:0051085]; response to unfolded protein [GO:0006986]	
O75964	reviewed	ATP5L_HUMAN	ATP synthase subunit g, mitochondrial (ATPase subunit g) (ATP synthase membrane subunit g)	ATP5MG ATP5L	Homo sapiens (Human)	103	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.		proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]	proton transmembrane transporter activity [GO:0015078]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]; proton transmembrane transporter activity [GO:0015078]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane.
O75973	reviewed	C1QRF_HUMAN	C1q-related factor (C1q and tumor necrosis factor-related protein 14) (C1q/TNF-related protein 14) (Complement component 1 Q subcomponent-like 1)	C1QL1 C1QRF CRF CTRP14	Homo sapiens (Human)	258	FUNCTION: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). {ECO:0000250}.		locomotory behavior [GO:0007626]; maintenance of synapse structure [GO:0099558]; motor learning [GO:0061743]; neuron remodeling [GO:0016322]; regulation of synapse pruning [GO:1905806]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; climbing fiber [GO:0044301]; collagen trimer [GO:0005581]; cytoplasm [GO:0005737]; presynapse [GO:0098793]; synaptic cleft [GO:0043083]	signaling receptor binding [GO:0005102]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; climbing fiber [GO:0044301]; collagen trimer [GO:0005581]; cytoplasm [GO:0005737]; presynapse [GO:0098793]; synaptic cleft [GO:0043083]; signaling receptor binding [GO:0005102]; locomotory behavior [GO:0007626]; maintenance of synapse structure [GO:0099558]; motor learning [GO:0061743]; neuron remodeling [GO:0016322]; regulation of synapse pruning [GO:1905806]	SUBCELLULAR LOCATION: Secreted.
O76001	reviewed	OR2J3_HUMAN	Olfactory receptor 2J3 (Hs6M1-3) (Olfactory receptor OR6-16) (OR6-6) (Olfactory receptor 6-6)	OR2J3	Homo sapiens (Human)	311	FUNCTION: Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'. {ECO:0000269|PubMed:22714804}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O76002	reviewed	OR2J2_HUMAN	Olfactory receptor 2J2 (Hs6M1-6) (Olfactory receptor 6-8) (OR6-8) (Olfactory receptor OR6-19)	OR2J2	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O76009	reviewed	KT33A_HUMAN	Keratin, type I cuticular Ha3-I (Hair keratin, type I Ha3-I) (Keratin-33A) (K33A)	KRT33A HHA3-I HKA3A KRTHA3A	Homo sapiens (Human)	404		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).	epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
O76099	reviewed	OR7C1_HUMAN	Olfactory receptor 7C1 (Olfactory receptor 7C4) (Olfactory receptor OR19-16) (Olfactory receptor TPCR86)	OR7C1 OR7C4	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O94772	reviewed	LY6H_HUMAN	Lymphocyte antigen 6H (Ly-6H)	LY6H	Homo sapiens (Human)	140	FUNCTION: Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. {ECO:0000250|UniProtKB:F1LNW6, ECO:0000250|UniProtKB:Q9WUC3}.		acetylcholine receptor signaling pathway [GO:0095500]; animal organ morphogenesis [GO:0009887]; nervous system development [GO:0007399]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]	acetylcholine receptor binding [GO:0033130]; acetylcholine receptor inhibitor activity [GO:0030550]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]; acetylcholine receptor binding [GO:0033130]; acetylcholine receptor inhibitor activity [GO:0030550]; acetylcholine receptor signaling pathway [GO:0095500]; animal organ morphogenesis [GO:0009887]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
O94844	reviewed	RHBT1_HUMAN	Rho-related BTB domain-containing protein 1	RHOBTB1 KIAA0740	Homo sapiens (Human)	696			actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]	endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]	endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]	
O94854	reviewed	K0754_HUMAN	Microtubule-actin cross-linking factor 1, isoforms 6/7 (Uncharacterized protein KIAA0754)	MACF1 KIAA0754	Homo sapiens (Human)	3515				cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|PROSITE-ProRule:PRU00792}.
O94889	reviewed	KLH18_HUMAN	Kelch-like protein 18	KLHL18 KIAA0795 OK/SW-cl.74	Homo sapiens (Human)	574	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis (PubMed:23213400). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400). Regulates light-and dark-dependent alpha-transducin localization changes in rod photoreceptors through UNC119 ubiquitination and degradation (By similarity). Preferentially ubiquitinates the unphosphorylated form of UNC119 over the phosphorylated form (By similarity). In the presence of UNC119, under dark-adapted conditions alpha-transducin mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light (By similarity). {ECO:0000250|UniProtKB:E9Q4F2, ECO:0000269|PubMed:23213400}.		cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of mitotic cell cycle phase transition [GO:1901992]; protein ubiquitination [GO:0016567]			cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of mitotic cell cycle phase transition [GO:1901992]; protein ubiquitination [GO:0016567]	
O94892	reviewed	ZN432_HUMAN	Zinc finger protein 432	ZNF432 KIAA0798	Homo sapiens (Human)	652	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O94903	reviewed	PLPHP_HUMAN	Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) (Proline synthase co-transcribed bacterial homolog protein) (Pyridoxal phosphate-binding protein)	PLPBP PROSC	Homo sapiens (Human)	275	FUNCTION: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. {ECO:0000255|HAMAP-Rule:MF_03225, ECO:0000269|PubMed:27912044}.			cytoplasm [GO:0005737]; cytosol [GO:0005829]	pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; pyridoxal phosphate binding [GO:0030170]	
O94988	reviewed	FA13A_HUMAN	Protein FAM13A	FAM13A FAM13A1 KIAA0914	Homo sapiens (Human)	1023			regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	
O95007	reviewed	OR6B1_HUMAN	Olfactory receptor 6B1 (Olfactory receptor 7-3) (OR7-3) (Olfactory receptor OR7-9)	OR6B1	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O95025	reviewed	SEM3D_HUMAN	Semaphorin-3D	SEMA3D UNQ760/PRO1491	Homo sapiens (Human)	777	FUNCTION: Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	extracellular space [GO:0005615]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]	extracellular space [GO:0005615]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
O95076	reviewed	ALX3_HUMAN	Homeobox protein aristaless-like 3 (Proline-rich transcription factor ALX3)	ALX3	Homo sapiens (Human)	343	FUNCTION: Transcriptional regulator with a possible role in patterning of mesoderm during development. {ECO:0000250}.		embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal system morphogenesis [GO:0048704]; pattern specification process [GO:0007389]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal system morphogenesis [GO:0048704]; pattern specification process [GO:0007389]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
O95084	reviewed	PRS23_HUMAN	Serine protease 23 (EC 3.4.21.-) (Putative secreted protein Zsig13)	PRSS23 ZSIG13 UNQ270/PRO307	Homo sapiens (Human)	383			proteolysis [GO:0006508]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O95164	reviewed	UBL3_HUMAN	Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1)	UBL3 PNSC1	Homo sapiens (Human)	117				extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]		extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
O95178	reviewed	NDUB2_HUMAN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (Complex I-AGGG) (CI-AGGG) (NADH-ubiquinone oxidoreductase AGGG subunit)	NDUFB2	Homo sapiens (Human)	105	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
O95190	reviewed	OAZ2_HUMAN	Ornithine decarboxylase antizyme 2 (AZ2) (ODC-Az 2)	OAZ2	Homo sapiens (Human)	189	FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity). {ECO:0000250|UniProtKB:O08608, ECO:0000269|PubMed:17900240}.		negative regulation of polyamine transmembrane transport [GO:1902268]; polyamine biosynthetic process [GO:0006596]; polyamine metabolic process [GO:0006595]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein catabolic process [GO:0045732]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	ornithine decarboxylase inhibitor activity [GO:0008073]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ornithine decarboxylase inhibitor activity [GO:0008073]; negative regulation of polyamine transmembrane transport [GO:1902268]; polyamine biosynthetic process [GO:0006596]; polyamine metabolic process [GO:0006595]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein catabolic process [GO:0045732]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
O95199	reviewed	RCBT2_HUMAN	RCC1 and BTB domain-containing protein 2 (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor) (Regulator of chromosome condensation and BTB domain-containing protein 2)	RCBTB2 CHC1L RLG	Homo sapiens (Human)	551				acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]	guanyl-nucleotide exchange factor activity [GO:0005085]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor activity [GO:0005085]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q99LJ7}. Note=Mainly found in the acrosomal cap region. {ECO:0000250|UniProtKB:Q99LJ7}.
O95222	reviewed	OR6A2_HUMAN	Olfactory receptor 6A2 (Olfactory receptor 11-55) (OR11-55) (Olfactory receptor 6A1) (Olfactory receptor OR11-83) (hP2 olfactory receptor)	OR6A2 OR6A1 OR6A2P	Homo sapiens (Human)	327	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O95260	reviewed	ATE1_HUMAN	Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1)	ATE1	Homo sapiens (Human)	518	FUNCTION: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues. {ECO:0000250|UniProtKB:Q9Z2A5}.		proteasomal protein catabolic process [GO:0010498]; protein arginylation [GO:0016598]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	arginyl-tRNA--protein transferase activity [GO:0004057]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; arginyl-tRNA--protein transferase activity [GO:0004057]; proteasomal protein catabolic process [GO:0010498]; protein arginylation [GO:0016598]	SUBCELLULAR LOCATION: [Isoform ATE1-1]: Nucleus {ECO:0000250|UniProtKB:Q9Z2A5}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z2A5}.; SUBCELLULAR LOCATION: [Isoform ATE1-2]: Cytoplasm {ECO:0000250|UniProtKB:Q9Z2A5}.
O95336	reviewed	6PGL_HUMAN	6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)	PGLS	Homo sapiens (Human)	258	FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. {ECO:0000269|PubMed:10518023}.		carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	6-phosphogluconolactonase activity [GO:0017057]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 6-phosphogluconolactonase activity [GO:0017057]; carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O95371	reviewed	OR2C1_HUMAN	Olfactory receptor 2C1 (OLFmf3) (Olfactory receptor 2C2) (Olfactory receptor OR16-1) (Olfactory receptor OR16-2)	OR2C1 OR2C2P	Homo sapiens (Human)	312	FUNCTION: Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanetiol (MTMT) (By similarity). Also binds odorants acetophenone and benzaldehyde (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). May be involved in the molecular processes underlying fasciculation and targeting of olfactory axons (By similarity). {ECO:0000250|UniProtKB:P23275}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	cell cortex [GO:0005938]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	cell cortex [GO:0005938]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P23275}; Multi-pass membrane protein {ECO:0000255}.
O95411	reviewed	TIAF1_HUMAN	Putative TGFB1-induced anti-apoptotic factor 1 (12 kDa TGF-beta-1-induced antiapoptotic factor)	MYO18A TIAF1	Homo sapiens (Human)	115	FUNCTION: [Isoform TIAF1]: Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. {ECO:0000269|PubMed:9918798}.		apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; negative regulation of apoptotic process [GO:0043066]	nucleus [GO:0005634]		nucleus [GO:0005634]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; negative regulation of apoptotic process [GO:0043066]	SUBCELLULAR LOCATION: [Isoform TIAF1]: Nucleus {ECO:0000269|PubMed:9918798}.
O95455	reviewed	TGDS_HUMAN	dTDP-D-glucose 4,6-dehydratase (EC 4.2.1.46)	TGDS	Homo sapiens (Human)	350			nucleotide-sugar metabolic process [GO:0009225]		dTDP-glucose 4,6-dehydratase activity [GO:0008460]	dTDP-glucose 4,6-dehydratase activity [GO:0008460]; nucleotide-sugar metabolic process [GO:0009225]	
O95620	reviewed	DUS4L_HUMAN	tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (EC 1.3.1.90) (pp35) (tRNA-dihydrouridine synthase 4-like)	DUS4L	Homo sapiens (Human)	317	FUNCTION: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. {ECO:0000269|PubMed:34798057}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	tRNA dihydrouridine synthesis [GO:0002943]		flavin adenine dinucleotide binding [GO:0050660]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine20a synthase activity [GO:0102266]; tRNA-dihydrouridine20b synthase activity [GO:0102267]	flavin adenine dinucleotide binding [GO:0050660]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine20a synthase activity [GO:0102266]; tRNA-dihydrouridine20b synthase activity [GO:0102267]; tRNA dihydrouridine synthesis [GO:0002943]	
O95625	reviewed	ZBT11_HUMAN	Zinc finger and BTB domain-containing protein 11	ZBTB11	Homo sapiens (Human)	1053	FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.		regulation of DNA-templated transcription [GO:0006355]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:29893856}.
O95661	reviewed	DIRA3_HUMAN	GTP-binding protein Di-Ras3 (Distinct subgroup of the Ras family member 3) (Rho-related GTP-binding protein RhoI)	DIRAS3 ARHI NOEY2 RHOI	Homo sapiens (Human)	229			regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of gene expression by genomic imprinting [GO:0006349]; small GTPase mediated signal transduction [GO:0007264]	plasma membrane [GO:0005886]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of gene expression by genomic imprinting [GO:0006349]; small GTPase mediated signal transduction [GO:0007264]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
O95665	reviewed	NTR2_HUMAN	Neurotensin receptor type 2 (NT-R-2) (NTR2) (Levocabastine-sensitive neurotensin receptor)	NTSR2	Homo sapiens (Human)	410	FUNCTION: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.		cell surface receptor signaling pathway [GO:0007166]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of membrane potential [GO:0042391]; sensory perception [GO:0007600]	plasma membrane [GO:0005886]	G protein-coupled neurotensin receptor activity [GO:0016492]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled neurotensin receptor activity [GO:0016492]; G protein-coupled receptor activity [GO:0004930]; cell surface receptor signaling pathway [GO:0007166]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of membrane potential [GO:0042391]; sensory perception [GO:0007600]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O95685	reviewed	PPR3D_HUMAN	Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6)	PPP1R3D PPP1R6	Homo sapiens (Human)	299	FUNCTION: Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.		glycogen metabolic process [GO:0005977]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]	glycogen granule [GO:0042587]; protein phosphatase type 1 complex [GO:0000164]	glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase activity [GO:0004722]	glycogen granule [GO:0042587]; protein phosphatase type 1 complex [GO:0000164]; glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase activity [GO:0004722]; glycogen metabolic process [GO:0005977]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]	
O95755	reviewed	RAB36_HUMAN	Ras-related protein Rab-36	RAB36	Homo sapiens (Human)	333	FUNCTION: Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250}.		protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus membrane; Lipid-anchor.
O95757	reviewed	HS74L_HUMAN	Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94)	HSPA4L APG1 OSP94	Homo sapiens (Human)	839	FUNCTION: Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. {ECO:0000250}.		protein folding [GO:0006457]; response to unfolded protein [GO:0006986]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=May translocate to the nucleus after heat shock. {ECO:0000250}.
O95759	reviewed	TBCD8_HUMAN	TBC1 domain family member 8 (AD 3) (Vascular Rab-GAP/TBC-containing protein)	TBC1D8 VRP	Homo sapiens (Human)	1140	FUNCTION: May act as a GTPase-activating protein for Rab family protein(s).		blood circulation [GO:0008015]; positive regulation of cell population proliferation [GO:0008284]	membrane [GO:0016020]	GTPase activator activity [GO:0005096]	membrane [GO:0016020]; GTPase activator activity [GO:0005096]; blood circulation [GO:0008015]; positive regulation of cell population proliferation [GO:0008284]	
O95780	reviewed	ZN682_HUMAN	Zinc finger protein 682	ZNF682	Homo sapiens (Human)	498	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O95838	reviewed	GLP2R_HUMAN	Glucagon-like peptide 2 receptor (GLP-2 receptor) (GLP-2-R) (GLP-2R)	GLP2R	Homo sapiens (Human)	553	FUNCTION: This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.		adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of cell population proliferation [GO:0008284]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; glucagon receptor activity [GO:0004967]; peptide hormone binding [GO:0017046]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; glucagon receptor activity [GO:0004967]; peptide hormone binding [GO:0017046]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O95841	reviewed	ANGL1_HUMAN	Angiopoietin-related protein 1 (Angiopoietin-3) (ANG-3) (Angiopoietin-like protein 1)	ANGPTL1 ANG3 ANGPT3 ARP1 PSEC0154 UNQ162/PRO188	Homo sapiens (Human)	491			transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	signaling receptor binding [GO:0005102]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; signaling receptor binding [GO:0005102]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10025962}.
O95918	reviewed	OR2H2_HUMAN	Olfactory receptor 2H2 (Hs6M1-12) (Olfactory receptor 2H3) (Olfactory receptor-like protein FAT11)	OR2H2 FAT11 OLFR2 OR2H3	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		defense response [GO:0006952]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; mating [GO:0007618]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; defense response [GO:0006952]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; mating [GO:0007618]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O95965	reviewed	ITGBL_HUMAN	Integrin beta-like protein 1 (Osteoblast-specific cysteine-rich protein) (Ten integrin EGF-like repeat domain-containing protein)	ITGBL1 OSCP TIED	Homo sapiens (Human)	494			cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229]	cell surface [GO:0009986]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]	integrin binding [GO:0005178]	cell surface [GO:0009986]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O95976	reviewed	IGSF6_HUMAN	Immunoglobulin superfamily member 6 (IgSF6) (Protein DORA)	IGSF6 DORA	Homo sapiens (Human)	241		MISCELLANEOUS: This gene is localized to a locus associated with inflammatory bowel disease. It is coded entirely within the intron of METTL9 which is transcribed in the opposite strand of the DNA.	cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]	plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
P01601	reviewed	KVD16_HUMAN	Immunoglobulin kappa variable 1D-16 (Ig kappa chain V-I region HK146) (Ig kappa chain V-I region HK189)	IGKV1D-16	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01614	reviewed	KVD40_HUMAN	Immunoglobulin kappa variable 2D-40 (Ig kappa chain V-II region Cum)	IGKV2D-40	Homo sapiens (Human)	121	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01624	reviewed	KV315_HUMAN	Immunoglobulin kappa variable 3-15 (Ig kappa chain V-III region CLL) (Ig kappa chain V-III region POM)	IGKV3-15	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01703	reviewed	LV140_HUMAN	Immunoglobulin lambda variable 1-40 (Ig lambda chain V-I region NEWM)	IGLV1-40	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01714	reviewed	LV319_HUMAN	Immunoglobulin lambda variable 3-19 (Ig lambda chain V-III region SH)	IGLV3-19	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01715	reviewed	LV301_HUMAN	Immunoglobulin lambda variable 3-1 (Ig lambda chain V-IV region Bau) (Ig lambda chain V-IV region MOL) (Ig lambda chain V-IV region X)	IGLV3-1	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01717	reviewed	LV325_HUMAN	Immunoglobulin lambda variable 3-25 (Ig lambda chain V-IV region Hil)	IGLV3-25	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01718	reviewed	LV327_HUMAN	Immunoglobulin lambda variable 3-27 (Ig lambda chain V-IV region Kern)	IGLV3-27	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01733	reviewed	TVBL3_HUMAN	T cell receptor beta variable 12-3 (T-cell receptor beta chain V region YT35)	TRBV12-3 TCRBV12S3 TCRBV8S1	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
P01743	reviewed	HV146_HUMAN	Immunoglobulin heavy variable 1-46 (Ig heavy chain V-I region DOT) (Ig heavy chain V-I region HG3) (Ig heavy chain V-I region Mot)	IGHV1-46	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01762	reviewed	HV311_HUMAN	Immunoglobulin heavy variable 3-11 (Ig heavy chain V-III region TRO)	IGHV3-11	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01763	reviewed	HV348_HUMAN	Immunoglobulin heavy variable 3-48 (Ig heavy chain V-III region WEA)	IGHV3-48	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01766	reviewed	HV313_HUMAN	Immunoglobulin heavy variable 3-13 (Ig heavy chain V-III region BRO)	IGHV3-13	Homo sapiens (Human)	116	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01767	reviewed	HV353_HUMAN	Immunoglobulin heavy variable 3-53 (Ig heavy chain V-III region BUT)	IGHV3-53	Homo sapiens (Human)	116	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01780	reviewed	HV307_HUMAN	Immunoglobulin heavy variable 3-7 (Ig heavy chain V-III region GAL) (Ig heavy chain V-III region GAR) (Ig heavy chain V-III region JON)	IGHV3-7	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01782	reviewed	HV309_HUMAN	Immunoglobulin heavy variable 3-9 (Ig heavy chain V-III region DOB)	IGHV3-9	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01817	reviewed	HV205_HUMAN	Immunoglobulin heavy variable 2-5 (Ig heavy chain V-II region HE) (Ig heavy chain V-II region MCE)	IGHV2-5	Homo sapiens (Human)	119	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01824	reviewed	HV439_HUMAN	Immunoglobulin heavy variable 4-39 (Ig heavy chain V-II region WAH)	IGHV4-39	Homo sapiens (Human)	125	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P01825	reviewed	HV459_HUMAN	Immunoglobulin heavy variable 4-59 (Ig heavy chain V-II region NEWM)	IGHV4-59	Homo sapiens (Human)	116	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P03901	reviewed	NU4LM_HUMAN	NADH-ubiquinone oxidoreductase chain 4L (EC 7.1.1.2) (NADH dehydrogenase subunit 4L)	MT-ND4L MTND4L NADH4L ND4L	Homo sapiens (Human)	98	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. {ECO:0000250|UniProtKB:P03902}.		aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein {ECO:0000255}.
P03979	reviewed	TRGV3_HUMAN	T cell receptor gamma variable 3 (T-cell receptor gamma V-gamma-1.1 region)	TRGV3 TCRGV3	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]; innate immune response [GO:0045087]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
P04211	reviewed	LV743_HUMAN	Immunoglobulin lambda variable 7-43 (Ig lambda chain V region 4A)	IGLV7-43	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P04430	reviewed	KV116_HUMAN	Immunoglobulin kappa variable 1-16 (Ig kappa chain V-I region BAN)	IGKV1-16	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P04432	reviewed	KVD39_HUMAN	Immunoglobulin kappa variable 1D-39 (Ig kappa chain V-I region Daudi)	IGKV1D-39	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P04433	reviewed	KV311_HUMAN	Immunoglobulin kappa variable 3-11 (Ig kappa chain V-III region VG)	IGKV3-11	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P04435	reviewed	TVB79_HUMAN	T cell receptor beta variable 7-9	TRBV7-9	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
P04437	reviewed	TVA29_HUMAN	T cell receptor alpha variable 29/delta variable 5	TRAV29DV5	Homo sapiens (Human)	119	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
P04808	reviewed	REL1_HUMAN	Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]	RLN1	Homo sapiens (Human)	185	FUNCTION: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.		female pregnancy [GO:0007565]; signal transduction [GO:0007165]	extracellular region [GO:0005576]	hormone activity [GO:0005179]	extracellular region [GO:0005576]; hormone activity [GO:0005179]; female pregnancy [GO:0007565]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted.
P05015	reviewed	IFN16_HUMAN	Interferon alpha-16 (IFN-alpha-16) (Interferon alpha-WA)	IFNA16	Homo sapiens (Human)	189	FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted.
P06310	reviewed	KV230_HUMAN	Immunoglobulin kappa variable 2-30 (Ig kappa chain V-II region RPMI 6410)	IGKV2-30	Homo sapiens (Human)	120	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P06315	reviewed	KV502_HUMAN	Immunoglobulin kappa variable 5-2 (Ig kappa chain V region EV15)	IGKV5-2	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P06331	reviewed	HV434_HUMAN	Immunoglobulin heavy variable 4-34 (Ig heavy chain V-II region ARH-77)	IGHV4-34	Homo sapiens (Human)	123	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P07311	reviewed	ACYP1_HUMAN	Acylphosphatase-1 (EC 3.6.1.7) (Acylphosphatase, erythrocyte isozyme) (Acylphosphatase, organ-common type isozyme) (Acylphosphate phosphohydrolase 1)	ACYP1 ACYPE	Homo sapiens (Human)	99			phosphate-containing compound metabolic process [GO:0006796]		acylphosphatase activity [GO:0003998]	acylphosphatase activity [GO:0003998]; phosphate-containing compound metabolic process [GO:0006796]	
P07316	reviewed	CRGB_HUMAN	Gamma-crystallin B (Gamma-B-crystallin) (Gamma-crystallin 1-2)	CRYGB CRYG2	Homo sapiens (Human)	175	FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.		lens development in camera-type eye [GO:0002088]; lens fiber cell morphogenesis [GO:0070309]; visual perception [GO:0007601]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	structural constituent of eye lens [GO:0005212]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; structural constituent of eye lens [GO:0005212]; lens development in camera-type eye [GO:0002088]; lens fiber cell morphogenesis [GO:0070309]; visual perception [GO:0007601]	
P09001	reviewed	RM03_HUMAN	Large ribosomal subunit protein uL3m (39S ribosomal protein L3, mitochondrial) (L3mt) (MRP-L3)	MRPL3 MRL3 RPML3	Homo sapiens (Human)	348			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
P09093	reviewed	CEL3A_HUMAN	Chymotrypsin-like elastase family member 3A (EC 3.4.21.70) (Elastase IIIA) (Elastase-3A) (Protease E)	CELA3A ELA3 ELA3A	Homo sapiens (Human)	270	FUNCTION: Efficient protease with alanine specificity but only little elastolytic activity.		proteolysis [GO:0006508]	extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]	extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	
P09105	reviewed	HBAT_HUMAN	Hemoglobin subunit theta-1 (Hemoglobin theta-1 chain) (Theta-1-globin)	HBQ1	Homo sapiens (Human)	142			cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]	haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]	haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]	
P09630	reviewed	HXC6_HUMAN	Homeobox protein Hox-C6 (Homeobox protein CP25) (Homeobox protein HHO.C8) (Homeobox protein Hox-3C)	HOXC6 HOX3C	Homo sapiens (Human)	235	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system development [GO:0048706]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system development [GO:0048706]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P0C0E4	reviewed	RB40L_HUMAN	Ras-related protein Rab-40A-like (Ras-like GTPase)	RAB40AL RLGP	Homo sapiens (Human)	278	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		intracellular signal transduction [GO:0035556]; protein localization to plasma membrane [GO:0072659]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; endosome [GO:0005768]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; endosome [GO:0005768]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular signal transduction [GO:0035556]; protein localization to plasma membrane [GO:0072659]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:22581972}. Mitochondrion {ECO:0000269|PubMed:12145744, ECO:0000269|PubMed:22581972}.
P0C1H6	reviewed	H2BFM_HUMAN	Histone H2B type F-M (Histone H2B.s) (H2B/s)	H2BW2 H2BFM	Homo sapiens (Human)	154	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	MISCELLANEOUS: In contrast to other H2B histones, it does not contain the conserved residue in C-terminus that is the target of monoubiquitination.		nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus. Chromosome.
P0C263	reviewed	SBK2_HUMAN	Serine/threonine-protein kinase SBK2 (EC 2.7.11.1) (SH3 domain-binding kinase family member 2) (Sugen kinase 69) (SgK069)	SBK2 SGK069	Homo sapiens (Human)	348			MAPK cascade [GO:0000165]; phosphorylation [GO:0016310]		ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; MAPK cascade [GO:0000165]; phosphorylation [GO:0016310]	
P0C617	reviewed	O5AL1_HUMAN	Olfactory receptor 5AL1 (Olfactory receptor OR11-184)	OR5AL1 OR5AL1P	Homo sapiens (Human)	329	FUNCTION: Odorant receptor. {ECO:0000305|PubMed:14983052}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0C645	reviewed	OR4E1_HUMAN	Olfactory receptor 4E1 (Olfactory receptor OR14-43)	OR4E1 OR4E1P	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0C6T2	reviewed	OST4_HUMAN	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4	OST4	Homo sapiens (Human)	37	FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes. {ECO:0000269|PubMed:23606741, ECO:0000269|PubMed:31831667}.		protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	endoplasmic reticulum membrane [GO:0005789]; oligosaccharyltransferase complex [GO:0008250]		endoplasmic reticulum membrane [GO:0005789]; oligosaccharyltransferase complex [GO:0008250]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000305|PubMed:23606741}. Endoplasmic reticulum membrane; Single-pass type III membrane protein {ECO:0000305}. Note=The single transmembrane helix has a kink in the middle of the transmembrane span.
P0C7H8	reviewed	KRA23_HUMAN	Keratin-associated protein 2-3 (High sulfur keratin-associated protein 2.4) (Keratin-associated protein 2.3)	KRTAP2-3 KAP2.3 KRTAP2.3	Homo sapiens (Human)	128	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P0C7M3	reviewed	SFTA3_HUMAN	Surfactant-associated protein 3 (Surfactant-associated protein H) (SP-H)	SFTA3 SFTPH	Homo sapiens (Human)	94	FUNCTION: Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface. {ECO:0000269|PubMed:29955092}.		wound healing [GO:0042060]	clathrin-coated endocytic vesicle [GO:0045334]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lamellar body [GO:0042599]		clathrin-coated endocytic vesicle [GO:0045334]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24743970, ECO:0000269|PubMed:29955092}. Secreted {ECO:0000269|PubMed:24743970, ECO:0000269|PubMed:29955092}.
P0C7M4	reviewed	RHF2B_HUMAN	Rhox homeobox family member 2B	RHOXF2B	Homo sapiens (Human)	288	FUNCTION: Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis. {ECO:0000269|PubMed:28171660}.		positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
P0C7M7	reviewed	ACSM4_HUMAN	Acyl-coenzyme A synthetase ACSM4, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 4)	ACSM4	Homo sapiens (Human)	580	FUNCTION: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for C6-12 fatty acids (By similarity). {ECO:0000250|UniProtKB:Q7TN78}.		acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]	mitochondrial matrix [GO:0005759]	ATP binding [GO:0005524]; butyrate-CoA ligase activity [GO:0047760]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; metal ion binding [GO:0046872]	mitochondrial matrix [GO:0005759]; ATP binding [GO:0005524]; butyrate-CoA ligase activity [GO:0047760]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; metal ion binding [GO:0046872]; acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q7TN78}.
P0C7P1	reviewed	RBY1D_HUMAN	RNA-binding motif protein, Y chromosome, family 1 member D	RBMY1D	Homo sapiens (Human)	496	FUNCTION: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.	MISCELLANEOUS: The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.	mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus.
P0C7U0	reviewed	ELFN1_HUMAN	Protein ELFN1 (Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1) (Protein phosphatase 1 regulatory subunit 28)	ELFN1 PPP1R28	Homo sapiens (Human)	828	FUNCTION: Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000250, ECO:0000269|PubMed:19389623}.		synapse organization [GO:0050808]	dendrite [GO:0030425]; excitatory synapse [GO:0060076]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]	protein phosphatase inhibitor activity [GO:0004864]	dendrite [GO:0030425]; excitatory synapse [GO:0060076]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; protein phosphatase inhibitor activity [GO:0004864]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to excitatory synapses onto somatostatin (Sst)-containing oriens-lacunosum moleculare (O-LM) interneurons. {ECO:0000250}.
P0C7U3	reviewed	ZH11B_HUMAN	Probable palmitoyltransferase ZDHHC11B (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 11B) (DHHC-11B)	ZDHHC11B	Homo sapiens (Human)	371	FUNCTION: Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (By similarity). May play a role in cell proliferation (PubMed:28331227). {ECO:0000250|UniProtKB:Q9H8X9, ECO:0000269|PubMed:28331227}.		protein targeting to membrane [GO:0006612]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
P0C862	reviewed	C1T9A_HUMAN	Complement C1q and tumor necrosis factor-related protein 9A (Complement C1q and tumor necrosis factor-related protein 9)	C1QTNF9 C1QTNF9A UNQ6503/PRO21380	Homo sapiens (Human)	333	FUNCTION: Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. {ECO:0000250|UniProtKB:Q4ZJN1}.			collagen trimer [GO:0005581]; extracellular region [GO:0005576]	hormone activity [GO:0005179]; identical protein binding [GO:0042802]	collagen trimer [GO:0005581]; extracellular region [GO:0005576]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
P0C8F1	reviewed	PATE4_HUMAN	Prostate and testis expressed protein 4 (PATE-like protein B) (PATE-B)	PATE4	Homo sapiens (Human)	98	FUNCTION: May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility. {ECO:0000269|PubMed:18387948}.		regulation of neurotransmitter receptor activity [GO:0099601]	acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615]	acetylcholine receptor regulator activity [GO:0030548]	acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615]; acetylcholine receptor regulator activity [GO:0030548]; regulation of neurotransmitter receptor activity [GO:0099601]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:18387948}.
P0CE72	reviewed	ONCO_HUMAN	Oncomodulin-1 (OM) (Parvalbumin beta)	OCM OCM1 OCMN	Homo sapiens (Human)	109	FUNCTION: Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.			cytoplasm [GO:0005737]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]	
P0CF74	reviewed	IGLC6_HUMAN	Immunoglobulin lambda constant 6 (Ig lambda-6 chain C region)	IGLC6	Homo sapiens (Human)	106	FUNCTION: Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.	MISCELLANEOUS: Displays the following serological isotype: Mgc-, Ke+, and Oz-. Mgc- has Ala-6, Ser-8 and Thr-57; Ke+ has Gly-46 and Oz- has Arg-83. {ECO:0000303|PubMed:3122211}.	adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgD immunoglobulin complex [GO:0071738]; IgE immunoglobulin complex [GO:0071742]; IgG immunoglobulin complex [GO:0071735]; IgM immunoglobulin complex [GO:0071753]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgD immunoglobulin complex [GO:0071738]; IgE immunoglobulin complex [GO:0071742]; IgG immunoglobulin complex [GO:0071735]; IgM immunoglobulin complex [GO:0071753]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0CG08	reviewed	GPHRB_HUMAN	Golgi pH regulator B (Protein GPR89B)	GPR89B GPHRB GPR89C HSPC201	Homo sapiens (Human)	455	FUNCTION: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (PubMed:18794847). Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:Q8BS95, ECO:0000269|PubMed:18794847}.	MISCELLANEOUS: Does not seem to be able to bind GTP.	intracellular pH reduction [GO:0051452]; protein transport [GO:0015031]; regulation of monoatomic ion transmembrane transport [GO:0034765]; T cell differentiation [GO:0030217]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	voltage-gated monoatomic anion channel activity [GO:0008308]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; voltage-gated monoatomic anion channel activity [GO:0008308]; intracellular pH reduction [GO:0051452]; protein transport [GO:0015031]; regulation of monoatomic ion transmembrane transport [GO:0034765]; T cell differentiation [GO:0030217]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:B2ZXD5}; Multi-pass membrane protein {ECO:0000255}.
P0CG13	reviewed	CTF8_HUMAN	Chromosome transmission fidelity protein 8 homolog (hCTF8)	CHTF8 CTF8	Homo sapiens (Human)	121	FUNCTION: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression. {ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166}.		DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; mitotic sister chromatid cohesion [GO:0007064]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	Ctf18 RFC-like complex [GO:0031390]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]	Ctf18 RFC-like complex [GO:0031390]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; mitotic sister chromatid cohesion [GO:0007064]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12766176}. Note=Associates with chromatin during S phase. {ECO:0000269|PubMed:12766176}.
P0CG21	reviewed	NHLC4_HUMAN	NHL-repeat-containing protein 4	NHLRC4	Homo sapiens (Human)	123							
P0CG29	reviewed	GST2_HUMAN	Glutathione S-transferase theta-2 (EC 2.5.1.18) (GST class-theta-2)	GSTT2	Homo sapiens (Human)	244	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:1417752). Has a sulfatase activity (PubMed:1417752). {ECO:0000269|PubMed:1417752}.		glutathione metabolic process [GO:0006749]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	glutathione transferase activity [GO:0004364]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; glutathione transferase activity [GO:0004364]; glutathione metabolic process [GO:0006749]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1417752}. Nucleus {ECO:0000250|UniProtKB:P30713}.
P0CG34	reviewed	TB15A_HUMAN	Thymosin beta-15A (NB thymosin beta) (Thymosin-like protein 8)	TMSB15A TMSL8 TMSNB	Homo sapiens (Human)	45	FUNCTION: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. {ECO:0000250|UniProtKB:P62328}.		actin filament organization [GO:0007015]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	actin monomer binding [GO:0003785]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; actin monomer binding [GO:0003785]; actin filament organization [GO:0007015]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P62328}.
P0CG35	reviewed	TB15B_HUMAN	Thymosin beta-15B	TMSB15B	Homo sapiens (Human)	45	FUNCTION: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration (PubMed:19296525). {ECO:0000250|UniProtKB:P62328, ECO:0000269|PubMed:19296525}.		actin filament organization [GO:0007015]; positive regulation of cell migration [GO:0030335]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	actin monomer binding [GO:0003785]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; actin monomer binding [GO:0003785]; actin filament organization [GO:0007015]; positive regulation of cell migration [GO:0030335]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P62328}.
P0CG38	reviewed	POTEI_HUMAN	POTE ankyrin domain family member I	POTEI	Homo sapiens (Human)	1075			axonogenesis [GO:0007409]; cell motility [GO:0048870]; retina homeostasis [GO:0001895]	actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202]	protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]	actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202]; protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; retina homeostasis [GO:0001895]	
P0CG39	reviewed	POTEJ_HUMAN	POTE ankyrin domain family member J	POTEJ	Homo sapiens (Human)	1038			axonogenesis [GO:0007409]; cell motility [GO:0048870]; retina homeostasis [GO:0001895]	actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202]	protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]	actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202]; protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; retina homeostasis [GO:0001895]	
P0CI25	reviewed	TRI49_HUMAN	Tripartite motif-containing protein 49 (RING finger protein 18) (Testis-specific RING-finger protein)	TRIM49 RNF18	Homo sapiens (Human)	452			innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
P0CW23	reviewed	AKAI1_HUMAN	A-kinase anchor protein inhibitor 1	AKAIN1 C18orf42	Homo sapiens (Human)	69	FUNCTION: Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177). {ECO:0000269|PubMed:25653177}.		negative regulation of protein-containing complex assembly [GO:0031333]; protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]	cytosol [GO:0005829]	protein kinase A binding [GO:0051018]	cytosol [GO:0005829]; protein kinase A binding [GO:0051018]; negative regulation of protein-containing complex assembly [GO:0031333]; protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]	
P0DJ07	reviewed	PT100_HUMAN	Protein PET100 homolog, mitochondrial	PET100 C19orf79	Homo sapiens (Human)	73	FUNCTION: Plays an essential role in mitochondrial complex IV maturation and assembly. {ECO:0000269|PubMed:24462369, ECO:0000269|PubMed:25293719}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]	mitochondrial inner membrane [GO:0005743]	unfolded protein binding [GO:0051082]	mitochondrial inner membrane [GO:0005743]; unfolded protein binding [GO:0051082]; mitochondrial cytochrome c oxidase assembly [GO:0033617]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250|UniProtKB:P0DJE0}. Mitochondrion inner membrane {ECO:0000269|PubMed:24462369}.
P0DN77	reviewed	OPSG2_HUMAN	Medium-wave-sensitive opsin 2 (Green cone photoreceptor pigment) (Green-sensitive opsin) (GOP) (Opsin 1 cone pigments medium-wave-sensitive 2)	OPN1MW2	Homo sapiens (Human)	364	FUNCTION: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. {ECO:0000250|UniProtKB:P04001}.		cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; visual perception [GO:0007601]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]	G protein-coupled photoreceptor activity [GO:0008020]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; G protein-coupled photoreceptor activity [GO:0008020]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04001}; Multi-pass membrane protein {ECO:0000255}.
P0DN78	reviewed	OPSG3_HUMAN	Medium-wave-sensitive opsin 3 (Green cone photoreceptor pigment) (Green-sensitive opsin) (GOP) (opsin 1 cone pigments medium-wave-sensitive 3)	OPN1MW3	Homo sapiens (Human)	364	FUNCTION: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. {ECO:0000250|UniProtKB:P04001}.		cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; visual perception [GO:0007601]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]	G protein-coupled photoreceptor activity [GO:0008020]	photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; G protein-coupled photoreceptor activity [GO:0008020]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04001}; Multi-pass membrane protein {ECO:0000255}.
P0DN87	reviewed	CGB7_HUMAN	Choriogonadotropin subunit beta 7	CGB7	Homo sapiens (Human)	165	FUNCTION: Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. {ECO:0000305}.	MISCELLANEOUS: Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates. {ECO:0000269|PubMed:11861891}.	apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; female gamete generation [GO:0007292]; G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	hormone activity [GO:0005179]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; female gamete generation [GO:0007292]; G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16123088}.
P0DUQ2	reviewed	PRAM9_HUMAN	PRAME family member 9	PRAMEF9	Homo sapiens (Human)	478	FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:26138980). The CRL2(PRAMEF9) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). {ECO:0000269|PubMed:26138980}.		negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	Cul2-RING ubiquitin ligase complex [GO:0031462]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	
P0DW28	reviewed	MNS60_HUMAN	Ribosome biogenesis inhibitor MINAS-60 (MINAS-60)	RBM10	Homo sapiens (Human)	130	FUNCTION: Acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus. {ECO:0000269|PubMed:35393574}.	MISCELLANEOUS: MINAS-60 is the product of an alternative open reading frame (alt-ORF) of transcripts coding for the RBM10 (AC P98175) protein (PubMed:35393574). MINAS-60 and RBM10 ORFs are overlapping and are formed by shifting the reading frame (PubMed:35393574). {ECO:0000269|PubMed:35393574}.	negative regulation of ribosomal large subunit export from nucleus [GO:2000204]	nucleolus [GO:0005730]		nucleolus [GO:0005730]; negative regulation of ribosomal large subunit export from nucleus [GO:2000204]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305|PubMed:35393574}.
P0DW81	reviewed	PACMP_HUMAN	Poly-ADP-ribosylation-amplifying and CtIP-maintaining micropeptide (PAR-amplifying and CtIP-maintaining micropeptide)	MARCHF6-DT PACMP	Homo sapiens (Human)	44	FUNCTION: Micropeptide that acts as a regulator of DNA repair both by preventing KLHL15-mediated ubiquitination and degradation of RBBP8/CtIP, and by promoting the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:35219381). Prevents KLHL15-mediated ubiquitination of RBBP8/CtIP by competitively blocking the association between KLHL15 and RBBP8/CtIP (PubMed:35219381). Recruited to DNA damage sites via association with poly-ADP-ribose chains, and enhances the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:35219381). {ECO:0000269|PubMed:35219381}.		negative regulation of protein ubiquitination [GO:0031397]; positive regulation of DNA repair [GO:0045739]; regulation of protein ADP-ribosylation [GO:0010835]	nucleolus [GO:0005730]; site of DNA damage [GO:0090734]	poly-ADP-D-ribose binding [GO:0072572]	nucleolus [GO:0005730]; site of DNA damage [GO:0090734]; poly-ADP-D-ribose binding [GO:0072572]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of DNA repair [GO:0045739]; regulation of protein ADP-ribosylation [GO:0010835]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:35219381}. Chromosome {ECO:0000269|PubMed:35219381}. Note=Recruited to DNA damage sites via interaction with poly-ADP-ribose chains. {ECO:0000269|PubMed:35219381}.
P10072	reviewed	ZN875_HUMAN	Zinc finger protein 875 (Krueppel-related zinc finger protein 1) (Protein HKR1)	ZNF875 HKR1	Homo sapiens (Human)	659	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P10266	reviewed	POK10_HUMAN	Endogenous retrovirus group K member 10 Pol protein (HERV-K10 Pol protein) (HERV-K107 Pol protein) (HERV-K_5q33.3 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]	ERVK-10	Homo sapiens (Human)	1014	FUNCTION: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein precursors. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Type 1 genomes lack a pol stop codon, leading to expression of a fusion protein containing a portion of the Env sequence.; MISCELLANEOUS: Exact N-terminus of this protein has not been formally described.	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]		DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]	DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]	
P12872	reviewed	MOTI_HUMAN	Promotilin [Cleaved into: Motilin; Motilin-associated peptide (MAP)]	MLN	Homo sapiens (Human)	115	FUNCTION: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.			extracellular region [GO:0005576]	hormone activity [GO:0005179]; motilin receptor binding [GO:0031788]	extracellular region [GO:0005576]; hormone activity [GO:0005179]; motilin receptor binding [GO:0031788]	SUBCELLULAR LOCATION: Secreted.
P14621	reviewed	ACYP2_HUMAN	Acylphosphatase-2 (EC 3.6.1.7) (Acylphosphatase, muscle type isozyme) (Acylphosphate phosphohydrolase 2)	ACYP2 ACYP	Homo sapiens (Human)	99	FUNCTION: Its physiological role is not yet clear.		phosphate-containing compound metabolic process [GO:0006796]		acylphosphatase activity [GO:0003998]; identical protein binding [GO:0042802]	acylphosphatase activity [GO:0003998]; identical protein binding [GO:0042802]; phosphate-containing compound metabolic process [GO:0006796]	
P15088	reviewed	CBPA3_HUMAN	Mast cell carboxypeptidase A (MC-CPA) (EC 3.4.17.1) (Carboxypeptidase A3)	CPA3	Homo sapiens (Human)	417			angiotensin maturation [GO:0002003]; proteolysis [GO:0006508]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; transport vesicle [GO:0030133]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; transport vesicle [GO:0030133]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; angiotensin maturation [GO:0002003]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules.
P15621	reviewed	ZNF44_HUMAN	Zinc finger protein 44 (Gonadotropin-inducible ovary transcription repressor 2) (GIOT-2) (Zinc finger protein 55) (Zinc finger protein 58) (Zinc finger protein KOX7)	ZNF44 GIOT2 KOX7 ZNF55 ZNF58	Homo sapiens (Human)	663	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P16260	reviewed	GDC_HUMAN	Solute carrier family 25 member 16 (Graves disease autoantigen) (GDA) (Graves disease carrier protein) (GDC) (Graves' didease protein) (hGP) (Mitochondrial solute carrier protein homolog)	SLC25A16 GDA	Homo sapiens (Human)	332	FUNCTION: May be involved in the transport of coenzyme A in the mitochondrial matrix (PubMed:11158296). Very little is known about the physiological function of this carrier (PubMed:11158296). {ECO:0000269|PubMed:11158296}.		coenzyme A biosynthetic process [GO:0015937]; mitochondrial coenzyme A transmembrane transport [GO:1990559]; mitochondrial transport [GO:0006839]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	antiporter activity [GO:0015297]; coenzyme A transmembrane transporter activity [GO:0015228]; secondary active transmembrane transporter activity [GO:0015291]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; antiporter activity [GO:0015297]; coenzyme A transmembrane transporter activity [GO:0015228]; secondary active transmembrane transporter activity [GO:0015291]; coenzyme A biosynthetic process [GO:0015937]; mitochondrial coenzyme A transmembrane transport [GO:1990559]; mitochondrial transport [GO:0006839]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:11158296}; Multi-pass membrane protein {ECO:0000255}.
P17019	reviewed	ZN708_HUMAN	Zinc finger protein 708 (Zinc finger protein 15) (Zinc finger protein 15-like 1) (Zinc finger protein KOX8)	ZNF708 KOX8 ZNF15 ZNF15L1	Homo sapiens (Human)	563	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17025	reviewed	ZN182_HUMAN	Zinc finger protein 182 (Zinc finger protein 21) (Zinc finger protein KOX14)	ZNF182 KOX14 ZNF21	Homo sapiens (Human)	639	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17026	reviewed	ZNF22_HUMAN	Zinc finger protein 22 (Zinc finger protein KOX15) (Zinc finger protein Krox-26)	ZNF22 KOX15 KROX26	Homo sapiens (Human)	224	FUNCTION: Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity). {ECO:0000250}.		odontogenesis [GO:0042476]; regulation of DNA-templated transcription [GO:0006355]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270]; odontogenesis [GO:0042476]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P17029	reviewed	ZKSC1_HUMAN	Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18)	ZKSCAN1 KOX18 ZNF139 ZNF36	Homo sapiens (Human)	563	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
P17030	reviewed	ZNF25_HUMAN	Zinc finger protein 25 (Zinc finger protein KOX19)	ZNF25 KOX19	Homo sapiens (Human)	456	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17031	reviewed	ZNF26_HUMAN	Zinc finger protein 26 (Zinc finger protein KOX20)	ZNF26 KOX20	Homo sapiens (Human)	533	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17032	reviewed	ZN37A_HUMAN	Zinc finger protein 37A (Zinc finger protein KOX21)	ZNF37A KOX21 ZNF37	Homo sapiens (Human)	561	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23922231}.
P17035	reviewed	ZNF28_HUMAN	Zinc finger protein 28 (Zinc finger protein KOX24)	ZNF28 KOX24	Homo sapiens (Human)	718	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17038	reviewed	ZNF43_HUMAN	Zinc finger protein 43 (Zinc finger protein 39) (Zinc finger protein HTF6) (Zinc finger protein KOX27)	ZNF43 KOX27 ZNF39 ZNF39L1	Homo sapiens (Human)	809	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17039	reviewed	ZNF30_HUMAN	Zinc finger protein 30 (Zinc finger protein KOX28)	ZNF30 KOX28	Homo sapiens (Human)	623	FUNCTION: May be involved in transcriptional regulation.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17097	reviewed	ZNF7_HUMAN	Zinc finger protein 7 (Zinc finger protein HF.16) (Zinc finger protein KOX4)	ZNF7 KOX4	Homo sapiens (Human)	686	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17098	reviewed	ZNF8_HUMAN	Zinc finger protein 8 (Zinc finger protein HF.18)	ZNF8	Homo sapiens (Human)	575	FUNCTION: Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. {ECO:0000250|UniProtKB:Q8BGV5}.		BMP signaling pathway [GO:0030509]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; BMP signaling pathway [GO:0030509]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P17538	reviewed	CTRB1_HUMAN	Chymotrypsinogen B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C]	CTRB1 CTRB	Homo sapiens (Human)	263			digestion [GO:0007586]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; digestion [GO:0007586]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space.
P19961	reviewed	AMY2B_HUMAN	Alpha-amylase 2B (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase 2B) (Carcinoid alpha-amylase)	AMY2B	Homo sapiens (Human)	511			carbohydrate metabolic process [GO:0005975]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	alpha-amylase activity [GO:0004556]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; alpha-amylase activity [GO:0004556]; metal ion binding [GO:0046872]; carbohydrate metabolic process [GO:0005975]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
P20382	reviewed	MCH_HUMAN	Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)]	PMCH MCH	Homo sapiens (Human)	165	FUNCTION: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.		cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; spermatogenesis [GO:0007283]	extracellular region [GO:0005576]; nucleus [GO:0005634]; synapse [GO:0045202]	melanin-concentrating hormone activity [GO:0030354]; type 1 melanin-concentrating hormone receptor binding [GO:0031777]	extracellular region [GO:0005576]; nucleus [GO:0005634]; synapse [GO:0045202]; melanin-concentrating hormone activity [GO:0030354]; type 1 melanin-concentrating hormone receptor binding [GO:0031777]; cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Secreted.
P21506	reviewed	ZNF10_HUMAN	Zinc finger protein 10 (Zinc finger protein KOX1)	ZNF10 KOX1	Homo sapiens (Human)	573	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]; protein-containing complex [GO:0032991]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23665872}.
P22090	reviewed	RS4Y1_HUMAN	Small ribosomal subunit protein eS4, Y isoform 1 (40S ribosomal protein S4)	RPS4Y1 RPS4Y PRO2646	Homo sapiens (Human)	263			translation [GO:0006412]	cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]	
P22531	reviewed	SPR2E_HUMAN	Small proline-rich protein 2E (SPR-2E) (Small proline-rich protein II) (SPR-II)	SPRR2E	Homo sapiens (Human)	72	FUNCTION: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.		epidermis development [GO:0008544]; keratinization [GO:0031424]; peptide cross-linking [GO:0018149]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	structural constituent of skin epidermis [GO:0030280]; structural molecule activity [GO:0005198]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; structural constituent of skin epidermis [GO:0030280]; structural molecule activity [GO:0005198]; epidermis development [GO:0008544]; keratinization [GO:0031424]; peptide cross-linking [GO:0018149]	SUBCELLULAR LOCATION: Cytoplasm.
P22532	reviewed	SPR2D_HUMAN	Small proline-rich protein 2D (SPR-2D) (Small proline-rich protein II) (SPR-II)	SPRR2D	Homo sapiens (Human)	72	FUNCTION: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.		epidermis development [GO:0008544]; keratinization [GO:0031424]	cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]		cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; epidermis development [GO:0008544]; keratinization [GO:0031424]	SUBCELLULAR LOCATION: Cytoplasm.
P22676	reviewed	CALB2_HUMAN	Calretinin (CR) (29 kDa calbindin)	CALB2 CAB29	Homo sapiens (Human)	271	FUNCTION: Calretinin is a calcium-binding protein which is abundant in auditory neurons.		regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]	cytosol [GO:0005829]; dendrite [GO:0030425]; gap junction [GO:0005921]; nucleus [GO:0005634]; parallel fiber to Purkinje cell synapse [GO:0098688]; synapse [GO:0045202]; terminal bouton [GO:0043195]	calcium ion binding [GO:0005509]; calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration [GO:0099534]	cytosol [GO:0005829]; dendrite [GO:0030425]; gap junction [GO:0005921]; nucleus [GO:0005634]; parallel fiber to Purkinje cell synapse [GO:0098688]; synapse [GO:0045202]; terminal bouton [GO:0043195]; calcium ion binding [GO:0005509]; calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration [GO:0099534]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]	
P25089	reviewed	FPR3_HUMAN	N-formyl peptide receptor 3 (FMLP-related receptor II) (FMLP-R-II) (Formyl peptide receptor-like 2)	FPR3 FPRH1 FPRL2	Homo sapiens (Human)	353	FUNCTION: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin (PubMed:15465011). {ECO:0000269|PubMed:15465011}.		chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; signal transduction [GO:0007165]	membrane [GO:0016020]; plasma membrane [GO:0005886]	complement receptor activity [GO:0004875]; N-formyl peptide receptor activity [GO:0004982]	membrane [GO:0016020]; plasma membrane [GO:0005886]; complement receptor activity [GO:0004875]; N-formyl peptide receptor activity [GO:0004982]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P27482	reviewed	CALL3_HUMAN	Calmodulin-like protein 3 (CaM-like protein) (CLP) (Calmodulin-related protein NB-1)	CALML3	Homo sapiens (Human)	149	FUNCTION: May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates. {ECO:0000269|PubMed:11278607, ECO:0000269|PubMed:18295593}.	MISCELLANEOUS: Binds four calcium ions.		extracellular exosome [GO:0070062]	calcium ion binding [GO:0005509]	extracellular exosome [GO:0070062]; calcium ion binding [GO:0005509]	
P29377	reviewed	S100G_HUMAN	Protein S100-G (Calbindin-D9k) (S100 calcium-binding protein G) (Vitamin D-dependent calcium-binding protein, intestinal) (CABP)	S100G CABP9K CALB3 S100D	Homo sapiens (Human)	79				apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914]; vitamin D binding [GO:0005499]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914]; vitamin D binding [GO:0005499]	
P29762	reviewed	RABP1_HUMAN	Cellular retinoic acid-binding protein 1 (Cellular retinoic acid-binding protein I) (CRABP-I)	CRABP1 RBP5	Homo sapiens (Human)	137	FUNCTION: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.		fatty acid transport [GO:0015908]; signal transduction [GO:0007165]	cytosol [GO:0005829]; nucleus [GO:0005634]	fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoic acid binding [GO:0001972]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]	cytosol [GO:0005829]; nucleus [GO:0005634]; fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoic acid binding [GO:0001972]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]; fatty acid transport [GO:0015908]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11909957}.
P30408	reviewed	T4S1_HUMAN	Transmembrane 4 L6 family member 1 (Membrane component chromosome 3 surface marker 1) (Tumor-associated antigen L6)	TM4SF1 M3S1 TAAL6	Homo sapiens (Human)	202			blastocyst formation [GO:0001825]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; blastocyst formation [GO:0001825]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note=Colocalizes with SDCBP2 in the apical region of the cell (PubMed:11102519). {ECO:0000269|PubMed:11102519}.
P30953	reviewed	OR1E1_HUMAN	Olfactory receptor 1E1 (Olfactory receptor 13-66) (OR13-66) (Olfactory receptor 17-2/17-32) (OR17-2) (OR17-32) (Olfactory receptor 1E5) (Olfactory receptor 1E6) (Olfactory receptor 5-85) (OR5-85) (Olfactory receptor OR17-18) (Olfactory receptor-like protein HGMP07I)	OR1E1 OR1E5 OR1E6 OR1E9P	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P30954	reviewed	O10J1_HUMAN	Olfactory receptor 10J1 (Olfactory receptor OR1-26) (Olfactory receptor-like protein HGMP07J)	OR10J1	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of chemical stimulus [GO:0007606]; single fertilization [GO:0007338]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of chemical stimulus [GO:0007606]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P31267	reviewed	HXA6_HUMAN	Homeobox protein Hox-A6 (Homeobox protein Hox-1B)	HOXA6 HOX1B	Homo sapiens (Human)	233	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system development [GO:0048706]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system development [GO:0048706]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P31277	reviewed	HXD11_HUMAN	Homeobox protein Hox-D11 (Homeobox protein Hox-4F)	HOXD11 HOX4F	Homo sapiens (Human)	338	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.		anatomical structure development [GO:0048856]; branching involved in ureteric bud morphogenesis [GO:0001658]; dorsal/ventral pattern formation [GO:0009953]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure development [GO:0048856]; branching involved in ureteric bud morphogenesis [GO:0001658]; dorsal/ventral pattern formation [GO:0009953]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
P32314	reviewed	FOXN2_HUMAN	Forkhead box protein N2 (Human T-cell leukemia virus enhancer factor)	FOXN2 HTLF	Homo sapiens (Human)	431	FUNCTION: Binds to the purine-rich region in HTLV-I LTR.		regulation of DNA-templated transcription [GO:0006355]; skeletal muscle cell differentiation [GO:0035914]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of DNA-templated transcription [GO:0006355]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus.
P33552	reviewed	CKS2_HUMAN	Cyclin-dependent kinases regulatory subunit 2 (CKS-2)	CKS2	Homo sapiens (Human)	79	FUNCTION: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.		cell division [GO:0051301]; fibroblast proliferation [GO:0048144]; meiosis I [GO:0007127]; mitotic cell cycle phase transition [GO:0044772]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; SCF ubiquitin ligase complex [GO:0019005]	chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; histone binding [GO:0042393]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; SCF ubiquitin ligase complex [GO:0019005]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; histone binding [GO:0042393]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; cell division [GO:0051301]; fibroblast proliferation [GO:0048144]; meiosis I [GO:0007127]; mitotic cell cycle phase transition [GO:0044772]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]	
P34820	reviewed	BMP8B_HUMAN	Bone morphogenetic protein 8B (BMP-8) (BMP-8B) (Osteogenic protein 2) (OP-2)	BMP8B BMP8	Homo sapiens (Human)	402	FUNCTION: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). {ECO:0000250}.		cartilage development [GO:0051216]; cell differentiation [GO:0030154]; ossification [GO:0001503]; skeletal system development [GO:0001501]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; ossification [GO:0001503]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
P34995	reviewed	PE2R1_HUMAN	Prostaglandin E2 receptor EP1 subtype (PGE receptor EP1 subtype) (PGE2 receptor EP1 subtype) (Prostanoid EP1 receptor)	PTGER1	Homo sapiens (Human)	402	FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.		adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to lipopolysaccharide [GO:0032496]	plasma membrane [GO:0005886]	D1 dopamine receptor binding [GO:0031748]; prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]; D1 dopamine receptor binding [GO:0031748]; prostaglandin E receptor activity [GO:0004957]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to lipopolysaccharide [GO:0032496]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P35325	reviewed	SPR2B_HUMAN	Small proline-rich protein 2B (SPR-2B)	SPRR2B	Homo sapiens (Human)	72	FUNCTION: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.		epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]	cornified envelope [GO:0001533]; cytosol [GO:0005829]		cornified envelope [GO:0001533]; cytosol [GO:0005829]; epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]	SUBCELLULAR LOCATION: Cytoplasm.
P35410	reviewed	MAS1L_HUMAN	Mas-related G-protein coupled receptor MRG (MAS-R) (MAS1-like)	MAS1L MRG	Homo sapiens (Human)	378			G protein-coupled receptor signaling pathway [GO:0007186]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	angiotensin receptor activity [GO:0001595]; G protein-coupled receptor activity [GO:0004930]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; angiotensin receptor activity [GO:0001595]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P35542	reviewed	SAA4_HUMAN	Serum amyloid A-4 protein (Constitutively expressed serum amyloid A protein) (C-SAA)	SAA4 CSAA	Homo sapiens (Human)	130	FUNCTION: Major acute phase reactant. {ECO:0000250|UniProtKB:P05366}.		acute-phase response [GO:0006953]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]		extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; acute-phase response [GO:0006953]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0DJI8}.
P35663	reviewed	CYLC1_HUMAN	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I)	CYLC1 CYL CYL1	Homo sapiens (Human)	651	FUNCTION: Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	acrosomal matrix [GO:0043159]; cytoskeletal calyx [GO:0033150]; nucleus [GO:0005634]	structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]	acrosomal matrix [GO:0043159]; cytoskeletal calyx [GO:0033150]; nucleus [GO:0005634]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.
P36537	reviewed	UDB10_HUMAN	UDP-glucuronosyltransferase 2B10 (UDPGT 2B10) (EC 2.4.1.17)	UGT2B10	Homo sapiens (Human)	528	FUNCTION: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.		cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; lipid metabolic process [GO:0006629]	endoplasmic reticulum membrane [GO:0005789]	UDP-glycosyltransferase activity [GO:0008194]	endoplasmic reticulum membrane [GO:0005789]; UDP-glycosyltransferase activity [GO:0008194]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P36915	reviewed	GNL1_HUMAN	Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1)	GNL1 HSR1	Homo sapiens (Human)	607	FUNCTION: Possible regulatory or functional link with the histocompatibility cluster.		DNA damage response [GO:0006974]; signal transduction [GO:0007165]; T cell mediated immunity [GO:0002456]	extracellular space [GO:0005615]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural molecule activity [GO:0005198]	extracellular space [GO:0005615]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural molecule activity [GO:0005198]; DNA damage response [GO:0006974]; signal transduction [GO:0007165]; T cell mediated immunity [GO:0002456]	
P40205	reviewed	NCYM_HUMAN	N-cym protein (N-myc opposite strand)	MYCNOS CYMN NCYM	Homo sapiens (Human)	109	FUNCTION: Regulates stability of MYCN in neuroblastoma cells by inhibiting GSK3B-mediated MYCN phosphorylation. Inhibits GSK3B activity by promoting its phosphorylation at 'Ser-9' (PubMed:24391509). {ECO:0000269|PubMed:24391509}.		negative regulation of kinase activity [GO:0033673]; regulation of protein stability [GO:0031647]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; negative regulation of kinase activity [GO:0033673]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24391509}. Nucleus {ECO:0000269|PubMed:24391509}.
P40313	reviewed	CTRL_HUMAN	Chymotrypsin-like protease CTRL-1 (EC 3.4.21.-)	CTRL CTRL1	Homo sapiens (Human)	264			protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	
P42357	reviewed	HUTH_HUMAN	Histidine ammonia-lyase (Histidase) (EC 4.3.1.3)	HAL HIS	Homo sapiens (Human)	657			histidine catabolic process [GO:0006548]; histidine catabolic process to glutamate and formamide [GO:0019556]; histidine catabolic process to glutamate and formate [GO:0019557]	cytosol [GO:0005829]	histidine ammonia-lyase activity [GO:0004397]	cytosol [GO:0005829]; histidine ammonia-lyase activity [GO:0004397]; histidine catabolic process [GO:0006548]; histidine catabolic process to glutamate and formamide [GO:0019556]; histidine catabolic process to glutamate and formate [GO:0019557]	
P42696	reviewed	RBM34_HUMAN	RNA-binding protein 34 (RNA-binding motif protein 34)	RBM34 KIAA0117	Homo sapiens (Human)	430		MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
P43116	reviewed	PE2R2_HUMAN	Prostaglandin E2 receptor EP2 subtype (PGE receptor EP2 subtype) (PGE2 receptor EP2 subtype) (Prostanoid EP2 receptor)	PTGER2	Homo sapiens (Human)	358	FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to prostaglandin E stimulus [GO:0071380]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cell population proliferation [GO:0042127]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to progesterone [GO:0032570]	plasma membrane [GO:0005886]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]; prostaglandin E receptor activity [GO:0004957]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to prostaglandin E stimulus [GO:0071380]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cell population proliferation [GO:0042127]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to progesterone [GO:0032570]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P43308	reviewed	SSRB_HUMAN	Translocon-associated protein subunit beta (TRAP-beta) (Signal sequence receptor subunit beta) (SSR-beta)	SSR2 TRAPB HSD25	Homo sapiens (Human)	183	FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.		cotranslational protein targeting to membrane [GO:0006613]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; cotranslational protein targeting to membrane [GO:0006613]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
P43363	reviewed	MAGAA_HUMAN	Melanoma-associated antigen 10 (Cancer/testis antigen 1.10) (CT1.10) (MAGE-10 antigen)	MAGEA10 MAGE10	Homo sapiens (Human)	369	FUNCTION: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.		negative regulation of transcription by RNA polymerase II [GO:0000122]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	histone deacetylase binding [GO:0042826]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone deacetylase binding [GO:0042826]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21710496}.
P43627	reviewed	KI2L2_HUMAN	Killer cell immunoglobulin-like receptor 2DL2 (CD158 antigen-like family member B1) (Natural killer-associated transcript 6) (NKAT-6) (p58 natural killer cell receptor clone CL-43) (p58 NK receptor CL-43) (CD antigen CD158b1)	KIR2DL2 CD158B1 NKAT6	Homo sapiens (Human)	348	FUNCTION: Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis. {ECO:0000269|PubMed:10097129}.			plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
P46095	reviewed	GPR6_HUMAN	G-protein coupled receptor 6 (Sphingosine 1-phosphate receptor GPR6)	GPR6	Homo sapiens (Human)	362	FUNCTION: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). {ECO:0000250}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of metabolic process [GO:0019222]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; sphingosine-1-phosphate receptor activity [GO:0038036]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; sphingosine-1-phosphate receptor activity [GO:0038036]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of metabolic process [GO:0019222]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:19059244}; Multi-pass membrane protein {ECO:0000305|PubMed:19059244}. Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor.
P47775	reviewed	GPR12_HUMAN	G-protein coupled receptor 12	GPR12	Homo sapiens (Human)	334	FUNCTION: Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production. {ECO:0000250}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; regulation of metabolic process [GO:0019222]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; phosphatidylcholine binding [GO:0031210]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; phosphatidylcholine binding [GO:0031210]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; regulation of metabolic process [GO:0019222]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P47874	reviewed	OMP_HUMAN	Olfactory marker protein (Olfactory neuronal-specific protein)	OMP	Homo sapiens (Human)	163	FUNCTION: May act as a modulator of the olfactory signal-transduction cascade.		chemical synaptic transmission [GO:0007268]; neurogenesis [GO:0022008]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	axon [GO:0030424]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synapse [GO:0045202]	peptide binding [GO:0042277]	axon [GO:0030424]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synapse [GO:0045202]; peptide binding [GO:0042277]; chemical synaptic transmission [GO:0007268]; neurogenesis [GO:0022008]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm.
P47883	reviewed	OR3A4_HUMAN	Putative olfactory receptor 3A4 (Olfactory receptor 17-24) (OR17-24) (Olfactory receptor 3A5)	OR3A4P OR3A4 OR3A5P	Homo sapiens (Human)	348	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P47887	reviewed	OR1E2_HUMAN	Olfactory receptor 1E2 (Olfactory receptor 17-93/17-135/17-136) (OR17-135) (OR17-136) (OR17-93) (Olfactory receptor 1E4)	OR1E2 OR1E4	Homo sapiens (Human)	323	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signaling receptor activity [GO:0038023]; sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P47888	reviewed	OR3A3_HUMAN	Olfactory receptor 3A3 (Olfactory receptor 17-201) (OR17-201) (Olfactory receptor 3A6) (Olfactory receptor 3A7) (Olfactory receptor 3A8) (Olfactory receptor OR17-22)	OR3A3 OR3A6 OR3A7 OR3A8P	Homo sapiens (Human)	321	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P47893	reviewed	OR3A2_HUMAN	Olfactory receptor 3A2 (Olfactory receptor 17-228) (OR17-228) (Olfactory receptor OR17-14)	OR3A2 OLFRA04	Homo sapiens (Human)	321	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signaling receptor activity [GO:0038023]; sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P47972	reviewed	NPTX2_HUMAN	Neuronal pentraxin-2 (NP2) (Neuronal pentraxin II) (NP-II)	NPTX2	Homo sapiens (Human)	431	FUNCTION: Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). {ECO:0000250}.		associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]	carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
P48060	reviewed	GLIP1_HUMAN	Glioma pathogenesis-related protein 1 (GliPR 1) (Protein RTVP-1)	GLIPR1 GLIPR RTVP1	Homo sapiens (Human)	266		MISCELLANEOUS: [Isoform 2]: Highly expressed in glioblastomas. {ECO:0000305}.		azurophil granule membrane [GO:0035577]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]		azurophil granule membrane [GO:0035577]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P49406	reviewed	RM19_HUMAN	Large ribosomal subunit protein bL19m (39S ribosomal protein L15, mitochondrial) (L15mt) (MRP-L15) (39S ribosomal protein L19, mitochondrial) (L19mt) (MRP-L19)	MRPL19 KIAA0104 MRPL15	Homo sapiens (Human)	292			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10600119, ECO:0000269|PubMed:11543634, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
P49441	reviewed	INPP_HUMAN	Inositol polyphosphate 1-phosphatase (IPP) (IPPase) (EC 3.1.3.57)	INPP1	Homo sapiens (Human)	399	FUNCTION: Mg(2+)-dependent phosphatase that catalyzes the hydrolysis of the 1-position phosphate from inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate and participates in inositol phosphate metabolism. {ECO:0000269|PubMed:8390685}.		phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; signal transduction [GO:0007165]	cytosol [GO:0005829]	inositol-1,3,4-trisphosphate 1-phosphatase activity [GO:0052829]; inositol-1,4-bisphosphate 1-phosphatase activity [GO:0004441]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; inositol-1,3,4-trisphosphate 1-phosphatase activity [GO:0052829]; inositol-1,4-bisphosphate 1-phosphatase activity [GO:0004441]; metal ion binding [GO:0046872]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; signal transduction [GO:0007165]	
P49750	reviewed	YLPM1_HUMAN	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113)	YLPM1 C14orf170 ZAP3	Homo sapiens (Human)	2146	FUNCTION: Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation. {ECO:0000250}.		regulation of telomere maintenance [GO:0032204]	nuclear speck [GO:0016607]; nucleus [GO:0005634]	RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA binding [GO:0003723]; regulation of telomere maintenance [GO:0032204]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17890166}. Nucleus speckle {ECO:0000250}. Note=Migrates to nucleolar caps upon blockage of transcription.
P50120	reviewed	RET2_HUMAN	Retinol-binding protein 2 (Cellular retinol-binding protein II) (CRBP-II)	RBP2 CRBP2	Homo sapiens (Human)	134	FUNCTION: Intracellular transport of retinol.		epidermis development [GO:0008544]; fatty acid transport [GO:0015908]; vitamin A metabolic process [GO:0006776]	cytosol [GO:0005829]; nucleus [GO:0005634]	fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]	cytosol [GO:0005829]; nucleus [GO:0005634]; fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]; epidermis development [GO:0008544]; fatty acid transport [GO:0015908]; vitamin A metabolic process [GO:0006776]	SUBCELLULAR LOCATION: Cytoplasm.
P51504	reviewed	ZNF80_HUMAN	Zinc finger protein 80 (ZNFpT17)	ZNF80	Homo sapiens (Human)	273	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P51508	reviewed	ZNF81_HUMAN	Zinc finger protein 81 (HFZ20)	ZNF81	Homo sapiens (Human)	661	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P51522	reviewed	ZNF83_HUMAN	Zinc finger protein 83 (Zinc finger protein 816B) (Zinc finger protein HPF1)	ZNF83 ZNF816B	Homo sapiens (Human)	516	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P51689	reviewed	ARSD_HUMAN	Arylsulfatase D (ASD) (EC 3.1.6.-)	ARSD	Homo sapiens (Human)	593				endoplasmic reticulum lumen [GO:0005788]; lysosome [GO:0005764]	arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]	endoplasmic reticulum lumen [GO:0005788]; lysosome [GO:0005764]; arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Lysosome {ECO:0000305}.
P51815	reviewed	ZN75D_HUMAN	Zinc finger protein 75D (Zinc finger protein 75) (Zinc finger protein 82)	ZNF75D ZNF75 ZNF82	Homo sapiens (Human)	510	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
P51911	reviewed	CNN1_HUMAN	Calponin-1 (Basic calponin) (Calponin H1, smooth muscle)	CNN1	Homo sapiens (Human)	297	FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; actomyosin structure organization [GO:0031032]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; regulation of smooth muscle contraction [GO:0006940]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]	actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; actin filament organization [GO:0007015]; actomyosin structure organization [GO:0031032]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; regulation of smooth muscle contraction [GO:0006940]	
P52737	reviewed	ZN136_HUMAN	Zinc finger protein 136	ZNF136	Homo sapiens (Human)	540	FUNCTION: May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P52741	reviewed	ZN134_HUMAN	Zinc finger protein 134	ZNF134	Homo sapiens (Human)	427	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	nucleoplasm [GO:0005654]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P52746	reviewed	ZN142_HUMAN	Zinc finger protein 142	ZNF142 KIAA0236	Homo sapiens (Human)	1687	FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P54792	reviewed	DVLP1_HUMAN	Putative segment polarity protein dishevelled homolog DVL1P1 (DSH homolog 1-like) (Segment polarity protein dishevelled homolog DVL-1-like) (Dishevelled-1-like)	DVL1P1 DVL DVL1 DVL1L1	Homo sapiens (Human)	670	FUNCTION: May play a role in the signal transduction pathway mediated by multiple Wnt genes.	MISCELLANEOUS: Part of that gene may be located in interstitial deletions of chromosome 22 associated with DiGeorge syndrome (DGS).	canonical Wnt signaling pathway [GO:0060070]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; planar cell polarity pathway involved in neural tube closure [GO:0090179]	cytosol [GO:0005829]	frizzled binding [GO:0005109]	cytosol [GO:0005829]; frizzled binding [GO:0005109]; canonical Wnt signaling pathway [GO:0060070]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; planar cell polarity pathway involved in neural tube closure [GO:0090179]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P54793	reviewed	ARSF_HUMAN	Arylsulfatase F (ASF) (EC 3.1.6.1)	ARSF	Homo sapiens (Human)	590	FUNCTION: Exhibits arylsulfatase activity towards the artificial substrate 4-methylumbelliferyl sulfate. {ECO:0000269|PubMed:9192838}.			endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]	arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P54826	reviewed	GAS1_HUMAN	Growth arrest-specific protein 1 (GAS-1)	GAS1	Homo sapiens (Human)	345	FUNCTION: Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. {ECO:0000269|PubMed:8127893}.		cell cycle [GO:0007049]; cell fate commitment [GO:0045165]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; developmental growth [GO:0048589]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein processing [GO:0010955]; regulation of apoptotic process [GO:0042981]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of smoothened signaling pathway [GO:0008589]	membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell cycle [GO:0007049]; cell fate commitment [GO:0045165]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; developmental growth [GO:0048589]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein processing [GO:0010955]; regulation of apoptotic process [GO:0042981]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of smoothened signaling pathway [GO:0008589]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
P55103	reviewed	INHBC_HUMAN	Inhibin beta C chain (Activin beta-C chain)	INHBC	Homo sapiens (Human)	352	FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.			extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; transforming growth factor beta receptor binding [GO:0005160]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; transforming growth factor beta receptor binding [GO:0005160]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
P55808	reviewed	XG_HUMAN	Glycoprotein Xg (Protein PBDX)	XG PBDX	Homo sapiens (Human)	180		MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.	homotypic cell-cell adhesion [GO:0034109]; positive regulation of neutrophil extravasation [GO:2000391]; T cell extravasation [GO:0072683]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; homotypic cell-cell adhesion [GO:0034109]; positive regulation of neutrophil extravasation [GO:2000391]; T cell extravasation [GO:0072683]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7533029}; Single-pass type I membrane protein {ECO:0000269|PubMed:7533029}.
P56179	reviewed	DLX6_HUMAN	Homeobox protein DLX-6	DLX6	Homo sapiens (Human)	175			anatomical structure formation involved in morphogenesis [GO:0048646]; cell differentiation [GO:0030154]; embryonic limb morphogenesis [GO:0030326]; epithelial cell differentiation [GO:0030855]; head development [GO:0060322]; inner ear morphogenesis [GO:0042472]; nervous system development [GO:0007399]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure formation involved in morphogenesis [GO:0048646]; cell differentiation [GO:0030154]; embryonic limb morphogenesis [GO:0030326]; epithelial cell differentiation [GO:0030855]; head development [GO:0060322]; inner ear morphogenesis [GO:0042472]; nervous system development [GO:0007399]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
P56277	reviewed	CMC4_HUMAN	Cx9C motif-containing protein 4 (Mature T-cell proliferation 1 neighbor protein) (Mature T-cell proliferation-1 type A) (MTCP-1 type A) (Protein p8 MTCP-1) (p8MTCP1)	CMC4 C6.1B MTCP1 MTCP1NB	Homo sapiens (Human)	68		MISCELLANEOUS: [Isoform 1]: Shares a non-coding 5' exon with isoform 2 which is spliced to a different set of 3' exons encoding an unrelated protein.		mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]		mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:7784073}.
P56378	reviewed	ATP68_HUMAN	ATP synthase subunit ATP5MJ, mitochondrial (6.8 kDa mitochondrial proteolipid protein) (MLQ) (ATP synthase membrane subunit 6.8PL)	ATP5MJ ATP5MPL C14orf2 MP68 PRO1574	Homo sapiens (Human)	58	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). Minor subunit required to maintain the ATP synthase population in the mitochondria (PubMed:24330338). {ECO:0000269|PubMed:24330338, ECO:0000305}.		proton motive force-driven ATP synthesis [GO:0015986]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]		mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; proton motive force-driven ATP synthesis [GO:0015986]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:24330338}; Single-pass membrane protein {ECO:0000255}.
P56385	reviewed	ATP5I_HUMAN	ATP synthase subunit e, mitochondrial (ATPase subunit e) (ATP synthase membrane subunit e) [Cleaved into: ATP synthase subunit e, mitochondrial, N-terminally processed]	ATP5ME ATP5I ATP5K	Homo sapiens (Human)	69	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.		proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]	proton transmembrane transporter activity [GO:0015078]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]; proton transmembrane transporter activity [GO:0015078]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane.
P57058	reviewed	HUNK_HUMAN	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (B19) (Serine/threonine-protein kinase MAK-V)	HUNK MAKV	Homo sapiens (Human)	714			intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; signal transduction [GO:0007165]	
P57077	reviewed	M3KCL_HUMAN	MAP3K7 C-terminal-like protein (TAK1-like protein)	MAP3K7CL C21orf7 TAK1L	Homo sapiens (Human)	142				cytosol [GO:0005829]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleus [GO:0005634]	
P57723	reviewed	PCBP4_HUMAN	Poly(rC)-binding protein 4 (Alpha-CP4)	PCBP4	Homo sapiens (Human)	403	FUNCTION: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}.		negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of mRNA stability [GO:0043488]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of mRNA stability [GO:0043488]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14612387}.
P57738	reviewed	TCTA_HUMAN	T-cell leukemia translocation-altered gene protein (T-cell leukemia translocation-associated gene protein)	TCTA	Homo sapiens (Human)	103	FUNCTION: May be required for cellular fusion during osteoclastogenesis. {ECO:0000269|PubMed:19560569}.		negative regulation of osteoclast differentiation [GO:0045671]; osteoclast fusion [GO:0072675]	membrane [GO:0016020]		membrane [GO:0016020]; negative regulation of osteoclast differentiation [GO:0045671]; osteoclast fusion [GO:0072675]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P57773	reviewed	CXA9_HUMAN	Gap junction alpha-9 protein (Connexin-58) (Cx58) (Connexin-59) (Cx59) (Gap junction alpha-10 protein)	GJA9 GJA10	Homo sapiens (Human)	515	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.		cell-cell signaling [GO:0007267]	connexin complex [GO:0005922]	gap junction channel activity [GO:0005243]	connexin complex [GO:0005922]; gap junction channel activity [GO:0005243]; cell-cell signaling [GO:0007267]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
P57775	reviewed	FBXW4_HUMAN	F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)	FBXW4 FBW4 SHFM3	Homo sapiens (Human)	412	FUNCTION: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.		embryonic limb morphogenesis [GO:0030326]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]		cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; embryonic limb morphogenesis [GO:0030326]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]	
P58062	reviewed	ISK7_HUMAN	Serine protease inhibitor Kazal-type 7 (Esophagus cancer-related gene 2 protein) (ECRG-2)	SPINK7 ECG2 UNQ745/PRO1474	Homo sapiens (Human)	85	FUNCTION: Probable serine protease inhibitor.		inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]	extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P58166	reviewed	INHBE_HUMAN	Inhibin beta E chain (Activin beta-E chain)	INHBE	Homo sapiens (Human)	350	FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.			collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
P58173	reviewed	OR2B6_HUMAN	Olfactory receptor 2B6 (Hs6M1-32) (Olfactory receptor 2B1) (Olfactory receptor 2B5) (Olfactory receptor 5-40) (OR5-40) (Olfactory receptor 6-31) (OR6-31) (Olfactory receptor OR6-4)	OR2B6 OR2B1 OR2B1P OR2B5 OR2B6P	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
P58182	reviewed	O12D2_HUMAN	Olfactory receptor 12D2 (Hs6M1-20) (Olfactory receptor OR6-28)	OR12D2	Homo sapiens (Human)	307	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P58294	reviewed	PROK1_HUMAN	Prokineticin-1 (Endocrine-gland-derived vascular endothelial growth factor) (EG-VEGF) (Mambakine)	PROK1 UNQ600/PRO1186	Homo sapiens (Human)	105	FUNCTION: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. {ECO:0000269|PubMed:11259612, ECO:0000269|PubMed:11528470, ECO:0000269|PubMed:15292351, ECO:0000269|PubMed:17289879, ECO:0000269|PubMed:18339712}.		angiogenesis [GO:0001525]; endothelial cell proliferation [GO:0001935]; positive regulation of cell division [GO:0051781]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of angiogenesis [GO:0045765]; vascular endothelial cell proliferation [GO:0101023]	extracellular region [GO:0005576]	growth factor activity [GO:0008083]	extracellular region [GO:0005576]; growth factor activity [GO:0008083]; angiogenesis [GO:0001525]; endothelial cell proliferation [GO:0001935]; positive regulation of cell division [GO:0051781]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of angiogenesis [GO:0045765]; vascular endothelial cell proliferation [GO:0101023]	SUBCELLULAR LOCATION: Secreted.
P58317	reviewed	ZN121_HUMAN	Zinc finger protein 121 (Zinc finger protein 20)	ZNF121 ZNF20	Homo sapiens (Human)	390	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P58557	reviewed	YBEY_HUMAN	Endoribonuclease YbeY (EC 3.1.-.-)	YBEY C21orf57	Homo sapiens (Human)	167	FUNCTION: Single strand-specific metallo-endoribonuclease involved in rRNA maturation. {ECO:0000305|PubMed:28153719}.	MISCELLANEOUS: A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells. {ECO:0000305|PubMed:22042635}.	rRNA processing [GO:0006364]	nucleus [GO:0005634]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; RNA endonuclease activity [GO:0004521]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; RNA endonuclease activity [GO:0004521]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22042635}.
P58658	reviewed	EVA1C_HUMAN	Protein eva-1 homolog C (Protein FAM176C) (SUE21)	EVA1C C21orf63 C21orf64 FAM176C PRED34 UNQ2504/PRO5993	Homo sapiens (Human)	441	FUNCTION: Binds heparin. {ECO:0000269|PubMed:19470522}.			membrane [GO:0016020]	carbohydrate binding [GO:0030246]; heparin binding [GO:0008201]	membrane [GO:0016020]; carbohydrate binding [GO:0030246]; heparin binding [GO:0008201]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
P58872	reviewed	RHBL3_HUMAN	Rhomboid-related protein 3 (EC 3.4.21.105) (Ventrhoid transmembrane protein)	RHBDL3 RHBDL4 VRHO	Homo sapiens (Human)	404	FUNCTION: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. {ECO:0000250}.		proteolysis [GO:0006508]	membrane [GO:0016020]	calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]	membrane [GO:0016020]; calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P59025	reviewed	RTP1_HUMAN	Receptor-transporting protein 1 (3CxxC-type zinc finger protein 1)	RTP1 Z3CXXC1	Homo sapiens (Human)	263	FUNCTION: Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs. {ECO:0000250}.		detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Note=Effective cell surface expression depends upon interaction with olfactory receptors. {ECO:0000250}.
P59045	reviewed	NAL11_HUMAN	NACHT, LRR and PYD domains-containing protein 11 (Nucleotide-binding oligomerization domain protein 17) (PAAD-and NACHT domain-containing protein 10) (PYRIN-containing APAF1-like protein 6)	NLRP11 NALP11 NOD17 PAN10 PYPAF6	Homo sapiens (Human)	1033	FUNCTION: Involved in inflammation. {ECO:0000305}.		regulation of inflammatory response [GO:0050727]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]; RNA binding [GO:0003723]; regulation of inflammatory response [GO:0050727]	
P59074	reviewed	CHM4P_HUMAN	Putative charged multivesicular body protein 4B-like protein CHMP4BP1 (Charged multivesicular body protein 4B pseudogene 1)	CHMP4BP1 CGI-301	Homo sapiens (Human)	171			autophagosome maturation [GO:0097352]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; nuclear membrane reassembly [GO:0031468]; plasma membrane repair [GO:0001778]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	amphisome membrane [GO:1904930]; cytoplasmic side of plasma membrane [GO:0009898]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]		amphisome membrane [GO:1904930]; cytoplasmic side of plasma membrane [GO:0009898]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; autophagosome maturation [GO:0097352]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; nuclear membrane reassembly [GO:0031468]; plasma membrane repair [GO:0001778]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	
P59282	reviewed	TPPP2_HUMAN	Tubulin polymerization-promoting protein family member 2 (Protein p25-beta) (TPPP/p18)	TPPP2 C14orf8	Homo sapiens (Human)	170	FUNCTION: Probable regulator of microtubule dynamics required for sperm motility (Probable). In contrast to other members of the family, has no microtubule bundling activity (PubMed:17105200). {ECO:0000269|PubMed:17105200, ECO:0000305|PubMed:30680919}.		cell differentiation [GO:0030154]; microtubule polymerization [GO:0046785]; positive regulation of protein polymerization [GO:0032273]; regulation of flagellated sperm motility [GO:1901317]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; sperm flagellum [GO:0036126]	tubulin binding [GO:0015631]	cytosol [GO:0005829]; sperm flagellum [GO:0036126]; tubulin binding [GO:0015631]; cell differentiation [GO:0030154]; microtubule polymerization [GO:0046785]; positive regulation of protein polymerization [GO:0032273]; regulation of flagellated sperm motility [GO:1901317]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:17105200}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q0P5Y3}. Note=Present in the middle piece of sperm tail. {ECO:0000250|UniProtKB:Q0P5Y3}.
P59533	reviewed	T2R38_HUMAN	Taste receptor type 2 member 38 (T2R38) (PTC bitter taste receptor) (Taste receptor type 2 member 61) (T2R61)	TAS2R38 PTC	Homo sapiens (Human)	333	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P59534	reviewed	T2R39_HUMAN	Taste receptor type 2 member 39 (T2R39) (Taste receptor type 2 member 57) (T2R57)	TAS2R39	Homo sapiens (Human)	338	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P59535	reviewed	T2R40_HUMAN	Taste receptor type 2 member 40 (T2R40) (G-protein coupled receptor 60) (Taste receptor type 2 member 58) (T2R58)	TAS2R40 GPR60	Homo sapiens (Human)	323	FUNCTION: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.	MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P59537	reviewed	T2R43_HUMAN	Taste receptor type 2 member 43 (T2R43) (Taste receptor type 2 member 52) (T2R52)	TAS2R43	Homo sapiens (Human)	309	FUNCTION: Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186]	ciliary membrane [GO:0060170]; membrane [GO:0016020]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	ciliary membrane [GO:0060170]; membrane [GO:0016020]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:19628819}; Multi-pass membrane protein {ECO:0000269|PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269|PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia.
P59540	reviewed	T2R46_HUMAN	Taste receptor type 2 member 46 (T2R46) (Taste receptor type 2 member 54) (T2R54)	TAS2R46	Homo sapiens (Human)	309	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	ciliary membrane [GO:0060170]; membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]	ciliary membrane [GO:0060170]; membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:19628819}; Multi-pass membrane protein {ECO:0000269|PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269|PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia.
P59541	reviewed	T2R30_HUMAN	Taste receptor type 2 member 30 (T2R30) (Taste receptor type 2 member 47) (T2R47)	TAS2R30 TAS2R47	Homo sapiens (Human)	319	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P59543	reviewed	T2R20_HUMAN	Taste receptor type 2 member 20 (Taste receptor type 2 member 49) (T2R49) (Taste receptor type 2 member 56) (T2R56)	TAS2R20 TAS2R49	Homo sapiens (Human)	309	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P59544	reviewed	T2R50_HUMAN	Taste receptor type 2 member 50 (T2R50) (Taste receptor type 2 member 51) (T2R51)	TAS2R50	Homo sapiens (Human)	299	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P59768	reviewed	GBG2_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)	GNG2	Homo sapiens (Human)	71	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). {ECO:0000250}.		adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to prostaglandin E stimulus [GO:0071380]; fibroblast proliferation [GO:0048144]; G protein-coupled receptor signaling pathway [GO:0007186]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; plasma membrane [GO:0005886]	G-protein beta-subunit binding [GO:0031681]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; plasma membrane [GO:0005886]; G-protein beta-subunit binding [GO:0031681]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to prostaglandin E stimulus [GO:0071380]; fibroblast proliferation [GO:0048144]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P59796	reviewed	GPX6_HUMAN	Glutathione peroxidase 6 (GPx-6) (GSHPx-6) (EC 1.11.1.9)	GPX6	Homo sapiens (Human)	221			response to oxidative stress [GO:0006979]	extracellular region [GO:0005576]	glutathione peroxidase activity [GO:0004602]	extracellular region [GO:0005576]; glutathione peroxidase activity [GO:0004602]; response to oxidative stress [GO:0006979]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
P59797	reviewed	SELV_HUMAN	Selenoprotein V (SelV)	SELENOV SELV	Homo sapiens (Human)	346	FUNCTION: May be involved in a redox-related process. {ECO:0000305}.		response to selenium ion [GO:0010269]			response to selenium ion [GO:0010269]	
P59826	reviewed	BPIB3_HUMAN	BPI fold-containing family B member 3 (Ligand-binding protein RYA3) (Long palate, lung and nasal epithelium carcinoma-associated protein 3)	BPIFB3 C20orf185 LPLUNC3	Homo sapiens (Human)	472	FUNCTION: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity). {ECO:0000250}.		innate immune response [GO:0045087]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	lipid binding [GO:0008289]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; lipid binding [GO:0008289]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12837268}. Note=According to PubMed:12837268, it is cytoplasmic.
P60153	reviewed	RNAS9_HUMAN	Inactive ribonuclease-like protein 9	RNASE9	Homo sapiens (Human)	205	FUNCTION: Does not exhibit any ribonuclease activity. {ECO:0000269|PubMed:18992174, ECO:0000269|PubMed:19137000}.		defense response to Gram-positive bacterium [GO:0050830]	extracellular region [GO:0005576]	nucleic acid binding [GO:0003676]	extracellular region [GO:0005576]; nucleic acid binding [GO:0003676]; defense response to Gram-positive bacterium [GO:0050830]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P60331	reviewed	KR101_HUMAN	Keratin-associated protein 10-1 (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1)	KRTAP10-1 KAP10.1 KAP18-1 KRTAP10.1 KRTAP18-1 KRTAP18.1	Homo sapiens (Human)	282	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P60369	reviewed	KR103_HUMAN	Keratin-associated protein 10-3 (High sulfur keratin-associated protein 10.3) (Keratin-associated protein 10.3) (Keratin-associated protein 18-3) (Keratin-associated protein 18.3)	KRTAP10-3 KAP10.3 KAP18-3 KRTAP10.3 KRTAP18-3 KRTAP18.3	Homo sapiens (Human)	221	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P60413	reviewed	KR10C_HUMAN	Keratin-associated protein 10-12 (High sulfur keratin-associated protein 10.12) (Keratin-associated protein 10.12) (Keratin-associated protein 18-12) (Keratin-associated protein 18.12)	KRTAP10-12 KAP10.12 KAP18-12 KRTAP10.12 KRTAP18-12 KRTAP18.12	Homo sapiens (Human)	245	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P60509	reviewed	ERB1_HUMAN	Endogenous retrovirus group PABLB member 1 Env polyprotein (Endogenous retrovirus group PABLB member 1) (Envelope polyprotein) (HERV-R(b) Env protein) (HERV-R(b)_3p24.3 provirus ancestral Env polyprotein) [Includes: Surface protein domain (SU); Transmembrane protein domain (TM)]	ERVPABLB-1	Homo sapiens (Human)	514	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.			plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=At the origin, this retroviral envelope protein was localized in the virion. {ECO:0000305}.
P60608	reviewed	EFC2_HUMAN	Endogenous retrovirus group FC1 member 1 Env polyprotein (Envelope polyprotein) (Fc2deltaenv) (HERV-F(c)2_7q36.2 provirus ancestral Env polyprotein) [Includes: Surface protein (SU); Truncated transmembrane protein (TM)]	ERVFC1-1	Homo sapiens (Human)	527	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.	MISCELLANEOUS: Orthologs in P.troglodytes (truncated), G.gorilla (truncated).					SUBCELLULAR LOCATION: Virion.
P60827	reviewed	C1QT8_HUMAN	Complement C1q tumor necrosis factor-related protein 8 (C1q/TNF-related protein 8) (CTRP8)	C1QTNF8 UNQ5829/PRO19648	Homo sapiens (Human)	252	FUNCTION: May play a role as ligand of RXFP1. {ECO:0000269|PubMed:24014093}.		positive regulation of cell motility [GO:2000147]	collagen trimer [GO:0005581]; extracellular space [GO:0005615]		collagen trimer [GO:0005581]; extracellular space [GO:0005615]; positive regulation of cell motility [GO:2000147]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19666007, ECO:0000269|PubMed:24014093}.
P60893	reviewed	GPR85_HUMAN	Probable G-protein coupled receptor 85 (Super conserved receptor expressed in brain 2)	GPR85 SREB2	Homo sapiens (Human)	370	FUNCTION: Orphan receptor.		signal transduction [GO:0007165]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:25780553}.
P60983	reviewed	GMFB_HUMAN	Glia maturation factor beta (GMF-beta)	GMFB	Homo sapiens (Human)	142	FUNCTION: This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.		actin filament debranching [GO:0071846]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; nervous system development [GO:0007399]; protein phosphorylation [GO:0006468]		actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; enzyme activator activity [GO:0008047]; growth factor activity [GO:0008083]; protein kinase inhibitor activity [GO:0004860]	actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; enzyme activator activity [GO:0008047]; growth factor activity [GO:0008083]; protein kinase inhibitor activity [GO:0004860]; actin filament debranching [GO:0071846]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; nervous system development [GO:0007399]; protein phosphorylation [GO:0006468]	
P61366	reviewed	OSTN_HUMAN	Osteocrin (Musclin) [Cleaved into: Processed Osteocrin]	OSTN	Homo sapiens (Human)	133	FUNCTION: Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity). {ECO:0000250|UniProtKB:P61364, ECO:0000269|PubMed:27830782}.		cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; endochondral bone growth [GO:0003416]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of dendrite extension [GO:1903860]; negative regulation of glucose import [GO:0046325]; negative regulation of osteoblast differentiation [GO:0045668]	extracellular space [GO:0005615]	hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]	extracellular space [GO:0005615]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; endochondral bone growth [GO:0003416]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of dendrite extension [GO:1903860]; negative regulation of glucose import [GO:0046325]; negative regulation of osteoblast differentiation [GO:0045668]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14523025}.
P61550	reviewed	ENVT1_HUMAN	Endogenous retrovirus group S71 member 1 Env polyprotein (Envelope polyprotein) (HERV-T Env protein) (HERV-T_19q13.11 provirus ancestral Env polyprotein) [Includes: Surface protein (SU); Transmembrane protein (TM)]	ERVS71-1	Homo sapiens (Human)	626	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.			plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=At the origin, this retroviral envelope protein was localized in the virion. {ECO:0000305}.
P61565	reviewed	ENK21_HUMAN	Endogenous retrovirus group K member 21 Env polyprotein (EnvK1 protein) (Envelope polyprotein) (HERV-K_12q14.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERVK-21	Homo sapiens (Human)	698	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: ERVK-21 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.		plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.; SUBCELLULAR LOCATION: [Endogenous retrovirus group K member 21 Env polyprotein]: Virion {ECO:0000250}.
P61566	reviewed	ENK24_HUMAN	Endogenous retrovirus group K member 24 Env polyprotein (Envelope polyprotein) (HERV-K101 envelope protein) (HERV-K_22q11.21 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERVK-24	Homo sapiens (Human)	588	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: This envelope protein is encoded by a human specific provirus.; MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.; MISCELLANEOUS: Intergenic, closest flanking gene being PRODH.		plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.; SUBCELLULAR LOCATION: [Endogenous retrovirus group K member 24 Env polyprotein]: Virion {ECO:0000250}.
P61567	reviewed	ENK7_HUMAN	Endogenous retrovirus group K member 7 Env polyprotein (Envelope polyprotein) (HERV-K(III) envelope protein) (HERV-K102 envelope protein) (HERV-K_1q22 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERVK-7	Homo sapiens (Human)	588	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: This envelope protein is encoded by a human specific provirus.; MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.		plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: Virion.; SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P62683	reviewed	GAK21_HUMAN	Endogenous retrovirus group K member 21 Gag polyprotein (HERV-K_12q14.1 provirus ancestral Gag polyprotein) (Gag polyprotein)	ERVK-21	Homo sapiens (Human)	666	FUNCTION: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.		viral process [GO:0016032]	plasma membrane [GO:0005886]	nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]; nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.
P62684	reviewed	GA113_HUMAN	Endogenous retrovirus group K member 113 Gag polyprotein (HERV-K113 Gag protein) (HERV-K_19p13.11 provirus ancestral Gag polyprotein) (Gag polyprotein)	HERVK_113	Homo sapiens (Human)	666	FUNCTION: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: Insertional polymorphism. Provirus present in 29% of tested individuals.	viral process [GO:0016032]	plasma membrane [GO:0005886]	nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]; nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.
P63123	reviewed	VPK18_HUMAN	Endogenous retrovirus group K member 18 Pro protein (HERV-K(C1a) Pro protein) (HERV-K110 Pro protein) (HERV-K18 Pro protein) (HERV-K_1q23.3 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)	ERVK-18	Homo sapiens (Human)	156	FUNCTION: Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: Intragenic, in the first intron of CD48 gene.	proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; proteolysis [GO:0006508]	
P63126	reviewed	GAK9_HUMAN	Endogenous retrovirus group K member 9 Gag polyprotein (HERV-K(C6) Gag protein) (HERV-K109 Gag protein) (HERV-K_6q14.1 provirus ancestral Gag polyprotein) (Gag polyprotein)	ERVK-9	Homo sapiens (Human)	666	FUNCTION: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: This Gag protein is encoded by a human specific provirus.; MISCELLANEOUS: [Isoform 2]: Gag-Pro polyprotein is produced from conventional translation of the gag ORF.	viral process [GO:0016032]	plasma membrane [GO:0005886]	nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]; nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.
P63129	reviewed	VPK24_HUMAN	Endogenous retrovirus group K member 24 Pro protein (HERV-K101 envelope protein) (HERV-K_22q11.21 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)	ERVK-24	Homo sapiens (Human)	156	FUNCTION: Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein has retained most of the characteristics of retroviral proteases.		proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; proteolysis [GO:0006508]	
P63130	reviewed	GAK7_HUMAN	Endogenous retrovirus group K member 7 Gag polyprotein (HERV-K(III) Gag protein) (HERV-K102 Gag protein) (HERV-K_1q22 provirus ancestral Gag polyprotein) (Gag polyprotein)	ERVK-7	Homo sapiens (Human)	666	FUNCTION: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: This protein is synthesized as a Gag polypeptide and as a Gag-Pro-Pol polyprotein. The later is the precursor of the Pro and Pol proteins. It is thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; MISCELLANEOUS: This Gag protein is encoded by a human specific provirus.	viral process [GO:0016032]	plasma membrane [GO:0005886]	nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]; nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.
P63132	reviewed	PO113_HUMAN	Endogenous retrovirus group K member 113 Pol protein (HERV-K113 Pol protein) (HERV-K_19p13.11 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]	HERVK_113	Homo sapiens (Human)	956	FUNCTION: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein precursors. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; MISCELLANEOUS: Exact N-terminus of this protein has not been formally described.; MISCELLANEOUS: Insertional polymorphism. Provirus present in 29% of tested individuals.	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]		DNA binding [GO:0003677]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]	DNA binding [GO:0003677]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]	
P63133	reviewed	POK8_HUMAN	Endogenous retrovirus group K member 8 Pol protein (HERV-K115 Pol protein) (HERV-K_8p23.1 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]	ERVK-8	Homo sapiens (Human)	956	FUNCTION: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein precursors. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; MISCELLANEOUS: Exact N-terminus of this protein has not been formally described.; MISCELLANEOUS: Insertional polymorphism. Provirus present in 16% of tested individuals.; MISCELLANEOUS: Intragenic, in first intron of DEFB107 gene.	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]		DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]	DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]	
P63135	reviewed	POK7_HUMAN	Endogenous retrovirus group K member 7 Pol protein (HERV-K(III) Pol protein) (HERV-K102 Pol protein) (HERV-K_1q22 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]	ERVK-7	Homo sapiens (Human)	1459	FUNCTION: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein precursors. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Type 1 genomes lack a pol stop codon, leading to expression of a fusion protein containing a portion of the Env sequence.; MISCELLANEOUS: Exact N-terminus of this protein has not been formally described.	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]		DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]	
P63136	reviewed	POK25_HUMAN	Endogenous retrovirus group K member 25 Pol protein (HERV-K_11q22.1 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]	ERVK-25	Homo sapiens (Human)	954	FUNCTION: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity). {ECO:0000250}.	MISCELLANEOUS: This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein precursors. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; MISCELLANEOUS: Exact N-terminus of this protein has not been formally described.	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]		DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]	DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]	
P63145	reviewed	GAK24_HUMAN	Endogenous retrovirus group K member 24 Gag polyprotein (HERV-K101 Gag protein) (HERV-K_22q11.21 provirus ancestral Gag polyprotein) (Gag polyprotein)	ERVK-24	Homo sapiens (Human)	666	FUNCTION: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: This Gag protein is encoded by a human specific provirus.; MISCELLANEOUS: Intergenic, closest flanking gene being PRODH.	viral process [GO:0016032]	plasma membrane [GO:0005886]	nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]; nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.
P63215	reviewed	GBG3_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNG3 GNGT3	Homo sapiens (Human)	75	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.		G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	cell body [GO:0044297]; dendrite [GO:0030425]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]	cell body [GO:0044297]; dendrite [GO:0030425]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
P63313	reviewed	TYB10_HUMAN	Thymosin beta-10	TMSB10 PTMB10 THYB10	Homo sapiens (Human)	44	FUNCTION: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	actin monomer binding [GO:0003785]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; actin monomer binding [GO:0003785]; actin filament organization [GO:0007015]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
P68543	reviewed	UBX2A_HUMAN	UBX domain-containing protein 2A (UBX domain-containing protein 4)	UBXN2A UBXD4	Homo sapiens (Human)	259			autophagosome assembly [GO:0000045]; cellular response to leukemia inhibitory factor [GO:1990830]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; nuclear membrane reassembly [GO:0031468]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176]; regulation of protein ubiquitination [GO:0031396]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	acetylcholine receptor binding [GO:0033130]; ubiquitin binding [GO:0043130]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; acetylcholine receptor binding [GO:0033130]; ubiquitin binding [GO:0043130]; autophagosome assembly [GO:0000045]; cellular response to leukemia inhibitory factor [GO:1990830]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; nuclear membrane reassembly [GO:0031468]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176]; regulation of protein ubiquitination [GO:0031396]	
P78414	reviewed	IRX1_HUMAN	Iroquois-class homeodomain protein IRX-1 (Homeodomain protein IRXA1) (Iroquois homeobox protein 1)	IRX1 IRXA1	Homo sapiens (Human)	480			cell development [GO:0048468]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; proximal/distal pattern formation involved in metanephric nephron development [GO:0072272]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of loop of Henle identity [GO:0072086]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; cell development [GO:0048468]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; proximal/distal pattern formation involved in metanephric nephron development [GO:0072272]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of loop of Henle identity [GO:0072086]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P80748	reviewed	LV321_HUMAN	Immunoglobulin lambda variable 3-21 (Ig lambda chain V-III region LOI) (Ig lambda chain V-V region DEL) (Ig lambda chain V-VII region MOT)	IGLV3-21	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P81133	reviewed	SIM1_HUMAN	Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14)	SIM1 BHLHE14	Homo sapiens (Human)	766	FUNCTION: Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.		cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]; ureteric bud development [GO:0001657]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]; ureteric bud development [GO:0001657]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00632, ECO:0000255|PROSITE-ProRule:PRU00981}.
P81877	reviewed	SSBP2_HUMAN	Single-stranded DNA-binding protein 2 (Sequence-specific single-stranded-DNA-binding protein 2)	SSBP2 SSDP2	Homo sapiens (Human)	361			positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; single-stranded DNA binding [GO:0003697]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P82663	reviewed	RT25_HUMAN	Small ribosomal subunit protein mS25 (28S ribosomal protein S25, mitochondrial) (MRP-S25) (S25mt)	MRPS25 RPMS25	Homo sapiens (Human)	173			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
P82673	reviewed	RT35_HUMAN	Small ribosomal subunit protein mS35 (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt)	MRPS35 MRPS28 HDCMD11P MDS023 PSEC0213	Homo sapiens (Human)	323			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
P82675	reviewed	RT05_HUMAN	Small ribosomal subunit protein uS5m (28S ribosomal protein S5, mitochondrial) (MRP-S5) (S5mt)	MRPS5	Homo sapiens (Human)	430		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
P82912	reviewed	RT11_HUMAN	Small ribosomal subunit protein uS11m (28S ribosomal protein S11, mitochondrial) (MRP-S11) (S11mt) (Cervical cancer proto-oncogene 2 protein) (HCC-2)	MRPS11 RPMS11 HCC2	Homo sapiens (Human)	194			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
P82921	reviewed	RT21_HUMAN	Small ribosomal subunit protein bS21m (28S ribosomal protein S21, mitochondrial) (MRP-S21) (S21mt)	MRPS21 RPMS21 MDS016	Homo sapiens (Human)	87			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
P82933	reviewed	RT09_HUMAN	Small ribosomal subunit protein uS9m (28S ribosomal protein S9, mitochondrial) (MRP-S9) (S9mt)	MRPS9 RPMS9	Homo sapiens (Human)	396			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
P82970	reviewed	HMGN5_HUMAN	High mobility group nucleosome-binding domain-containing protein 5 (Nucleosome-binding protein 1)	HMGN5 NSBP1	Homo sapiens (Human)	282	FUNCTION: Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. {ECO:0000250}.		chromatin organization [GO:0006325]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355]	chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]	chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; chromatin organization [GO:0006325]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11161810}. Note=Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin. {ECO:0000250}.
P82980	reviewed	RET5_HUMAN	Retinol-binding protein 5 (Cellular retinol-binding protein III) (CRBP-III) (HRBPiso)	RBP5	Homo sapiens (Human)	135	FUNCTION: Intracellular transport of retinol. {ECO:0000269|PubMed:11274389}.		fatty acid transport [GO:0015908]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]; fatty acid transport [GO:0015908]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
P83859	reviewed	OX26_HUMAN	Orexigenic neuropeptide QRFP (P518) [Cleaved into: QRF-amide (Neuropeptide RF-amide) (Pyroglutamylated arginine-phenylalanine-amide peptide)]	QRFP	Homo sapiens (Human)	136	FUNCTION: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity). {ECO:0000250, ECO:0000269|PubMed:12960173, ECO:0000269|PubMed:14657341}.		grooming behavior [GO:0007625]; locomotory behavior [GO:0007626]; neuropeptide signaling pathway [GO:0007218]; positive regulation of blood pressure [GO:0045777]; regulation of feeding behavior [GO:0060259]	extracellular region [GO:0005576]	neuropeptide hormone activity [GO:0005184]; orexigenic neuropeptide QRFP receptor binding [GO:0031854]	extracellular region [GO:0005576]; neuropeptide hormone activity [GO:0005184]; orexigenic neuropeptide QRFP receptor binding [GO:0031854]; grooming behavior [GO:0007625]; locomotory behavior [GO:0007626]; neuropeptide signaling pathway [GO:0007218]; positive regulation of blood pressure [GO:0045777]; regulation of feeding behavior [GO:0060259]	SUBCELLULAR LOCATION: Secreted.
P84101	reviewed	SERF2_HUMAN	Small EDRK-rich factor 2 (Gastric cancer-related protein VRG107) (Protein 4F5-related) (4F5rel) (h4F5rel)	SERF2 FAM2C	Homo sapiens (Human)	59	FUNCTION: Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (PubMed:20723760). {ECO:0000269|PubMed:20723760}.		protein destabilization [GO:0031648]	cytosol [GO:0005829]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleus [GO:0005634]; protein destabilization [GO:0031648]	
P86791	reviewed	CCZ1_HUMAN	Vacuolar fusion protein CCZ1 homolog	CCZ1 C7orf28A CGI-43	Homo sapiens (Human)	482	FUNCTION: Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991). {ECO:0000269|PubMed:23084991}.		vesicle-mediated transport [GO:0016192]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658]; guanyl-nucleotide exchange factor activity [GO:0005085]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319}.
P87889	reviewed	GAK10_HUMAN	Endogenous retrovirus group K member 10 Gag polyprotein (HERV-K10 Gag protein) (HERV-K107 Gag protein) (HERV-K_5q33.3 provirus ancestral Gag polyprotein) (Gag polyprotein)	ERVK-10	Homo sapiens (Human)	666	FUNCTION: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: This Gag protein is encoded by a human specific provirus.; MISCELLANEOUS: Intragenic, in the sixth intron of the SCGD gene.	viral process [GO:0016032]	plasma membrane [GO:0005886]	nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]; nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system).
P98169	reviewed	ZXDB_HUMAN	Zinc finger X-linked protein ZXDB	ZXDB	Homo sapiens (Human)	803	FUNCTION: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P98173	reviewed	FAM3A_HUMAN	Protein FAM3A (Cytokine-like protein 2-19)	FAM3A 2-19 2.19	Homo sapiens (Human)	230	FUNCTION: May act as a defensin against invading fungal microorganisms.		antifungal humoral response [GO:0019732]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; negative regulation of antifungal innate immune response [GO:1905035]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; antifungal humoral response [GO:0019732]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; negative regulation of antifungal innate immune response [GO:1905035]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q01459	reviewed	DIAC_HUMAN	Di-N-acetylchitobiase (EC 3.2.1.-)	CTBS CTB	Homo sapiens (Human)	385	FUNCTION: Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.		chitin catabolic process [GO:0006032]; oligosaccharide catabolic process [GO:0009313]	extracellular space [GO:0005615]; lysosome [GO:0005764]	chitin binding [GO:0008061]; chitinase activity [GO:0004568]	extracellular space [GO:0005615]; lysosome [GO:0005764]; chitin binding [GO:0008061]; chitinase activity [GO:0004568]; chitin catabolic process [GO:0006032]; oligosaccharide catabolic process [GO:0009313]	SUBCELLULAR LOCATION: Lysosome.
Q01995	reviewed	TAGL_HUMAN	Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha)	TAGLN SM22 WS3-10	Homo sapiens (Human)	201	FUNCTION: Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. {ECO:0000250}.		epithelial cell differentiation [GO:0030855]; muscle organ development [GO:0007517]	cytoplasm [GO:0005737]	actin binding [GO:0003779]	cytoplasm [GO:0005737]; actin binding [GO:0003779]; epithelial cell differentiation [GO:0030855]; muscle organ development [GO:0007517]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q02045	reviewed	MYL5_HUMAN	Myosin light chain 5 (Myosin regulatory light chain 5) (Superfast myosin regulatory light chain 2) (MYLC2) (MyLC-2)	MYL5	Homo sapiens (Human)	173		MISCELLANEOUS: This chain binds calcium. {ECO:0000250}.	regulation of muscle contraction [GO:0006937]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]	calcium ion binding [GO:0005509]; structural constituent of muscle [GO:0008307]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; calcium ion binding [GO:0005509]; structural constituent of muscle [GO:0008307]; regulation of muscle contraction [GO:0006937]	
Q02221	reviewed	CX6A2_HUMAN	Cytochrome c oxidase subunit 6A2, mitochondrial (Cytochrome c oxidase polypeptide VIa-heart) (COXVIAH) (Cytochrome c oxidase subunit VIA-muscle) (COX VIa-M)	COX6A2 COX6A COX6AH	Homo sapiens (Human)	97	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in the assembly and stabilization of complex IV (PubMed:31155743). {ECO:0000250|UniProtKB:P32799, ECO:0000269|PubMed:31155743}.		generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	mitochondrial respiratory chain complex IV [GO:0005751]	enzyme regulator activity [GO:0030234]; oxidoreductase activity [GO:0016491]	mitochondrial respiratory chain complex IV [GO:0005751]; enzyme regulator activity [GO:0030234]; oxidoreductase activity [GO:0016491]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07471}; Single-pass membrane protein {ECO:0000250|UniProtKB:P07471}.
Q02338	reviewed	BDH_HUMAN	D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH) (Short chain dehydrogenase/reductase family 9C member 1)	BDH1 BDH SDR9C1	Homo sapiens (Human)	343			steroid metabolic process [GO:0008202]	intracellular membrane-bounded organelle [GO:0043231]; matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	3-hydroxybutyrate dehydrogenase activity [GO:0003858]	intracellular membrane-bounded organelle [GO:0043231]; matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 3-hydroxybutyrate dehydrogenase activity [GO:0003858]; steroid metabolic process [GO:0008202]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q02337}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q02337}.
Q02386	reviewed	ZNF45_HUMAN	Zinc finger protein 45 (BRC1744) (Zinc finger protein 13) (Zinc finger protein KOX5)	ZNF45 KOX5 ZNF13	Homo sapiens (Human)	682	FUNCTION: May be involved in transcriptional regulation.			nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus.
Q02509	reviewed	OC90_HUMAN	Otoconin-90 (Oc90) (Phospholipase A2 homolog)	OC90 PLA2L	Homo sapiens (Human)	477	FUNCTION: Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity. {ECO:0000250|UniProtKB:Q9Z0L3}.		arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; otolith mineralization [GO:0045299]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid metabolic process [GO:0006644]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543]; structural molecule activity [GO:0005198]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543]; structural molecule activity [GO:0005198]; arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; otolith mineralization [GO:0045299]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid metabolic process [GO:0006644]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P81869}.
Q03169	reviewed	TNAP2_HUMAN	Tumor necrosis factor alpha-induced protein 2 (TNF alpha-induced protein 2) (Primary response gene B94 protein)	TNFAIP2	Homo sapiens (Human)	654	FUNCTION: May play a role as a mediator of inflammation and angiogenesis.		angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; exocyst localization [GO:0051601]; exocytosis [GO:0006887]	exocyst [GO:0000145]; extracellular space [GO:0005615]	SNARE binding [GO:0000149]	exocyst [GO:0000145]; extracellular space [GO:0005615]; SNARE binding [GO:0000149]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; exocyst localization [GO:0051601]; exocytosis [GO:0006887]	
Q03701	reviewed	CEBPZ_HUMAN	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor)	CEBPZ CBF2	Homo sapiens (Human)	1054	FUNCTION: Stimulates transcription from the HSP70 promoter.		positive regulation of transcription by RNA polymerase II [GO:0045944]	CCAAT-binding factor complex [GO:0016602]; nucleus [GO:0005634]	RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	CCAAT-binding factor complex [GO:0016602]; nucleus [GO:0005634]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus.
Q03828	reviewed	EVX2_HUMAN	Homeobox even-skipped homolog protein 2 (EVX-2)	EVX2	Homo sapiens (Human)	476			limb morphogenesis [GO:0035108]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; limb morphogenesis [GO:0035108]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q03936	reviewed	ZNF92_HUMAN	Zinc finger protein 92 (Zinc finger protein HTF12)	ZNF92	Homo sapiens (Human)	586	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q05048	reviewed	CSTF1_HUMAN	Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50)	CSTF1	Homo sapiens (Human)	431	FUNCTION: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (PubMed:10669729). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (PubMed:10669729). {ECO:0000303|PubMed:10669729}.		mRNA 3'-end processing [GO:0031124]	mRNA cleavage stimulating factor complex [GO:0005848]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	mRNA cleavage stimulating factor complex [GO:0005848]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; mRNA 3'-end processing [GO:0031124]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10477523}.
Q05952	reviewed	STP2_HUMAN	Nuclear transition protein 2 (TP-2) (TP2)	TNP2	Homo sapiens (Human)	138	FUNCTION: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. {ECO:0000250|UniProtKB:P11378}.		acrosome reaction [GO:0007340]; penetration of zona pellucida [GO:0007341]; positive regulation of protein processing [GO:0010954]; sperm DNA condensation [GO:0035092]; spermatogenesis [GO:0007283]	nucleolus [GO:0005730]; nucleosome [GO:0000786]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleosome [GO:0000786]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; acrosome reaction [GO:0007340]; penetration of zona pellucida [GO:0007341]; positive regulation of protein processing [GO:0010954]; sperm DNA condensation [GO:0035092]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P11101}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P11101}. Chromosome {ECO:0000250|UniProtKB:P11101}. Note=Loaded onto the nucleosomes of condensing spermatids (By similarity). Nuclear import is mediated by IPO4. Nucleolar localization requires the protein to be phosphorylated (By similarity). {ECO:0000250|UniProtKB:P11101, ECO:0000250|UniProtKB:P11378}.
Q05D32	reviewed	CTSL2_HUMAN	CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-)	CTDSPL2 HSPC058 HSPC129	Homo sapiens (Human)	466	FUNCTION: Probable phosphatase. {ECO:0000250}.		negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of protein export from nucleus [GO:0046827]; protein export from nucleus [GO:0006611]	nucleoplasm [GO:0005654]	phosphoprotein phosphatase activity [GO:0004721]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	nucleoplasm [GO:0005654]; phosphoprotein phosphatase activity [GO:0004721]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of protein export from nucleus [GO:0046827]; protein export from nucleus [GO:0006611]	
Q06732	reviewed	ZN33B_HUMAN	Zinc finger protein 33B (Zinc finger protein 11B) (Zinc finger protein KOX2)	ZNF33B KOX2 ZNF11B	Homo sapiens (Human)	778	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q07507	reviewed	DERM_HUMAN	Dermatopontin (Tyrosine-rich acidic matrix protein) (TRAMP)	DPT	Homo sapiens (Human)	201	FUNCTION: Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; negative regulation of cell population proliferation [GO:0008285]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]	extracellular matrix structural constituent [GO:0005201]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; negative regulation of cell population proliferation [GO:0008285]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q08ER8	reviewed	ZN543_HUMAN	Zinc finger protein 543	ZNF543	Homo sapiens (Human)	600	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q0D2J5	reviewed	ZN763_HUMAN	Zinc finger protein 763	ZNF763	Homo sapiens (Human)	394	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q0VDF9	reviewed	HSP7E_HUMAN	Heat shock 70 kDa protein 14 (HSP70-like protein 1) (Heat shock protein HSP60)	HSPA14 HSP60 HSP70L1	Homo sapiens (Human)	509	FUNCTION: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity. {ECO:0000269|PubMed:16002468}.	MISCELLANEOUS: Acts as a potent immunoadjuvant, capable to interact with antigen-presenting cells and generating efficient CD8(+) T-cell responses. May be used as adjuvant to enhance effect of vaccine G1F/M2, a candidate vaccine against respiratory syncytial virus (RSV), a major respiratory pathogen in newborns (PubMed:18851947). May also be used as adjuvant to prepare antigenic fusion protein for the therapeutics of cancers (PubMed:15930317). {ECO:0000305|PubMed:15930317, ECO:0000305|PubMed:18851947}.	'de novo' cotranslational protein folding [GO:0051083]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; 'de novo' cotranslational protein folding [GO:0051083]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16002468}.
Q0ZLH3	reviewed	PJVK_HUMAN	Pejvakin (Autosomal recessive deafness type 59 protein)	PJVK DFNB59	Homo sapiens (Human)	352	FUNCTION: Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation. {ECO:0000250|UniProtKB:Q0ZLH2}.	MISCELLANEOUS: 'Pejvakin' means 'echo' in Persian. {ECO:0000305|PubMed:16804542}.	detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; pexophagy [GO:0000425]; programmed cell death in response to reactive oxygen species [GO:0097468]; regulation of peroxisome organization [GO:1900063]; response to reactive oxygen species [GO:0000302]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045]	ciliary rootlet [GO:0035253]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; peroxisomal membrane [GO:0005778]; stereocilium base [GO:0120044]		ciliary rootlet [GO:0035253]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; peroxisomal membrane [GO:0005778]; stereocilium base [GO:0120044]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; pexophagy [GO:0000425]; programmed cell death in response to reactive oxygen species [GO:0097468]; regulation of peroxisome organization [GO:1900063]; response to reactive oxygen species [GO:0000302]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:Q0ZLH2}. Cell projection, cilium {ECO:0000250|UniProtKB:Q0ZLH2}. Note=Associates with the peroxisomal membrane; it is unclear whether it is embedded or just associated with the peroxisomal membrane. Localizes to ciliary rootlet. {ECO:0000250|UniProtKB:Q0ZLH2}.
Q12796	reviewed	PNRC1_HUMAN	Proline-rich nuclear receptor coactivator 1 (Proline-rich protein 2) (Protein B4-2)	PNRC1 PROL2	Homo sapiens (Human)	327	FUNCTION: Nuclear receptor coactivator. May play a role in signal transduction. {ECO:0000269|PubMed:10894149}.		nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]	nucleus [GO:0005634]; P-body [GO:0000932]		nucleus [GO:0005634]; P-body [GO:0000932]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q12829	reviewed	RB40B_HUMAN	Ras-related protein Rab-40B (SOCS box-containing protein RAR) (Protein Rar)	RAB40B SEC4L	Homo sapiens (Human)	278	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		intracellular signal transduction [GO:0035556]; protein localization to plasma membrane [GO:0072659]; protein ubiquitination [GO:0016567]; toxin transport [GO:1901998]	endosome [GO:0005768]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endosome [GO:0005768]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular signal transduction [GO:0035556]; protein localization to plasma membrane [GO:0072659]; protein ubiquitination [GO:0016567]; toxin transport [GO:1901998]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q12872	reviewed	SFSWA_HUMAN	Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog)	SFSWAP SFRS8 SWAP	Homo sapiens (Human)	951	FUNCTION: Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}.		alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA 5'-splice site recognition [GO:0000395]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]	nucleus [GO:0005634]	RNA binding [GO:0003723]	nucleus [GO:0005634]; RNA binding [GO:0003723]; alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA 5'-splice site recognition [GO:0000395]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q12894	reviewed	IFRD2_HUMAN	Interferon-related developmental regulator 2 (Protein SKMC15)	IFRD2	Homo sapiens (Human)	442	FUNCTION: Ribosome-binding protein that acts as an inhibitor of mRNA translation by promoting ribosome inactivation (PubMed:30355441). Associates with the P- and E-sites of the ribosome and inserts a C-terminal helix into the mRNA exit channel to preclude translation (By similarity). {ECO:0000250|UniProtKB:P0DX19, ECO:0000269|PubMed:30355441}.		negative regulation of translation [GO:0017148]	nucleus [GO:0005634]	ribosome binding [GO:0043022]; translation repressor activity [GO:0030371]	nucleus [GO:0005634]; ribosome binding [GO:0043022]; translation repressor activity [GO:0030371]; negative regulation of translation [GO:0017148]	
Q12901	reviewed	ZN155_HUMAN	Zinc finger protein 155	ZNF155	Homo sapiens (Human)	538	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q12926	reviewed	ELAV2_HUMAN	ELAV-like protein 2 (ELAV-like neuronal protein 1) (Hu-antigen B) (HuB) (Nervous system-specific RNA-binding protein Hel-N1)	ELAVL2 HUB	Homo sapiens (Human)	359	FUNCTION: RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity). {ECO:0000250|UniProtKB:Q60899}.		regulation of DNA-templated transcription [GO:0006355]	ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]	ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; regulation of DNA-templated transcription [GO:0006355]	
Q12950	reviewed	FOXD4_HUMAN	Forkhead box protein D4 (Forkhead-related protein FKHL9) (Forkhead-related transcription factor 5) (FREAC-5) (Myeloid factor-alpha)	FOXD4 FKHL9 FOXD4A FREAC5	Homo sapiens (Human)	439			anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding, bending [GO:0008301]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding, bending [GO:0008301]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus.
Q12988	reviewed	HSPB3_HUMAN	Heat shock protein beta-3 (HspB3) (Heat shock 17 kDa protein) (HSP 17) (Protein 3)	HSPB3 HSP27 HSPL27	Homo sapiens (Human)	150	FUNCTION: Inhibitor of actin polymerization.		response to unfolded protein [GO:0006986]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus {ECO:0000269|PubMed:19464326}. Note=Translocates to nuclear foci during heat shock.
Q12999	reviewed	TSN31_HUMAN	Tetraspanin-31 (Tspan-31) (Sarcoma-amplified sequence)	TSPAN31 SAS	Homo sapiens (Human)	210			positive regulation of cell population proliferation [GO:0008284]	membrane [GO:0016020]; plasma membrane [GO:0005886]		membrane [GO:0016020]; plasma membrane [GO:0005886]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q13103	reviewed	SPP24_HUMAN	Secreted phosphoprotein 24 (Spp-24) (Secreted phosphoprotein 2)	SPP2 SPP24	Homo sapiens (Human)	211	FUNCTION: Could coordinate an aspect of bone turnover. {ECO:0000250}.		bone remodeling [GO:0046849]; skeletal system development [GO:0001501]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089]	endopeptidase inhibitor activity [GO:0004866]	collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089]; endopeptidase inhibitor activity [GO:0004866]; bone remodeling [GO:0046849]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted.
Q13106	reviewed	ZN154_HUMAN	Zinc finger protein 154	ZNF154 KIAA2003	Homo sapiens (Human)	437	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q13203	reviewed	MYBPH_HUMAN	Myosin-binding protein H (MyBP-H) (H-protein)	MYBPH	Homo sapiens (Human)	477	FUNCTION: Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.		cell adhesion [GO:0007155]; regulation of striated muscle contraction [GO:0006942]	myosin filament [GO:0032982]	structural constituent of muscle [GO:0008307]	myosin filament [GO:0032982]; structural constituent of muscle [GO:0008307]; cell adhesion [GO:0007155]; regulation of striated muscle contraction [GO:0006942]	
Q13401	reviewed	PM2P3_HUMAN	Putative postmeiotic segregation increased 2-like protein 3 (PMS2-related protein 3) (Postmeiotic segregation increased 2-like protein 9) (Postmeiotic segregation increased protein 5) (Putative postmeiotic segregation increased 2 pseudogene 3)	PMS2P3 PMS2L3 PMS2L9 PMS5 PMSR3	Homo sapiens (Human)	168		MISCELLANEOUS: Encoded by one of the numerous copies of postmeiotic segregation increased 2-like genes scattered in the q11-q22 region of the chromosome 7.	mismatch repair [GO:0006298]; regulation of DNA-templated transcription [GO:0006355]	mismatch repair complex [GO:0032300]	ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]	mismatch repair complex [GO:0032300]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatch repair [GO:0006298]; regulation of DNA-templated transcription [GO:0006355]	
Q13434	reviewed	MKRN4_HUMAN	Putative E3 ubiquitin-protein ligase makorin-4 (EC 2.3.2.27) (Makorin RING finger protein pseudogene 4) (Makorin RING finger protein pseudogene 5) (RING finger protein 64) (RING-type E3 ubiquitin transferase makorin-4) (Zinc finger protein 127-Xp) (ZNF127-Xp) (Zinc finger protein 127-like 1)	MKRN4P MKRN4 MKRNP5 RNF64 ZNF127L1	Homo sapiens (Human)	485	FUNCTION: May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. {ECO:0000250}.		protein ubiquitination [GO:0016567]		metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]	
Q13442	reviewed	HAP28_HUMAN	28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1)	PDAP1 HASPP28	Homo sapiens (Human)	181	FUNCTION: Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. {ECO:0000250}.		signal transduction [GO:0007165]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]	RNA binding [GO:0003723]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]; signal transduction [GO:0007165]	
Q13474	reviewed	DRP2_HUMAN	Dystrophin-related protein 2 (DRP-2)	DRP2	Homo sapiens (Human)	957	FUNCTION: Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system. {ECO:0000250, ECO:0000250|UniProtKB:Q05AA6}.		central nervous system development [GO:0007417]; synapse organization [GO:0050808]; synaptic signaling [GO:0099536]	dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	zinc ion binding [GO:0008270]	dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; zinc ion binding [GO:0008270]; central nervous system development [GO:0007417]; synapse organization [GO:0050808]; synaptic signaling [GO:0099536]	SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250|UniProtKB:Q9EPA0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9EPA0}. Perikaryon {ECO:0000250|UniProtKB:Q9EPA0}. Cell membrane {ECO:0000250|UniProtKB:Q05AA6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q05AA6}. Note=Detected in Schwann cells at periaxonal myelin membranes. {ECO:0000250|UniProtKB:Q05AA6}.
Q13606	reviewed	OR5I1_HUMAN	Olfactory receptor 5I1 (Olfactory receptor OR11-159) (Olfactory receptor-like protein OLF1)	OR5I1 OLF1	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q13607	reviewed	OR2F1_HUMAN	Olfactory receptor 2F1 (Olfactory receptor 2F3) (Olfactory receptor 2F4) (Olfactory receptor 2F5) (Olfactory receptor-like protein OLF3)	OR2F1 OLF3 OR2F3 OR2F3P OR2F4 OR2F5	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q13939	reviewed	CALI_HUMAN	Calicin	CCIN	Homo sapiens (Human)	588	FUNCTION: Possible morphogenetic cytoskeletal element in spermiogenic differentiation.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	cytoskeletal calyx [GO:0033150]; nucleus [GO:0005634]		cytoskeletal calyx [GO:0033150]; nucleus [GO:0005634]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure tightly associated to the nucleus.
Q14093	reviewed	CYLC2_HUMAN	Cylicin-2 (Cylicin II) (Multiple-band polypeptide II)	CYLC2 CYL2	Homo sapiens (Human)	348	FUNCTION: Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	cytoskeletal calyx [GO:0033150]; nucleus [GO:0005634]	structural constituent of cytoskeleton [GO:0005200]	cytoskeletal calyx [GO:0033150]; nucleus [GO:0005634]; structural constituent of cytoskeleton [GO:0005200]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.
Q14094	reviewed	CCNI_HUMAN	Cyclin-I	CCNI	Homo sapiens (Human)	377			mitotic cell cycle phase transition [GO:0044772]; spermatogenesis [GO:0007283]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; mitotic cell cycle phase transition [GO:0044772]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:28860486}.
Q14201	reviewed	BTG3_HUMAN	Protein BTG3 (Abundant in neuroepithelium area protein) (BTG family member 3) (Protein Tob5)	BTG3 ANA TOB5	Homo sapiens (Human)	252	FUNCTION: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.		negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930]	
Q14206	reviewed	RCAN2_HUMAN	Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4)	RCAN2 DSCR1L1 ZAKI4	Homo sapiens (Human)	197	FUNCTION: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.		calcium-mediated signaling [GO:0019722]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; nucleic acid binding [GO:0003676]; calcium-mediated signaling [GO:0019722]	
Q14324	reviewed	MYPC2_HUMAN	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)	MYBPC2 MYBPCF	Homo sapiens (Human)	1141	FUNCTION: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.		cell adhesion [GO:0007155]	cytosol [GO:0005829]; myosin filament [GO:0032982]	actin binding [GO:0003779]; structural constituent of muscle [GO:0008307]	cytosol [GO:0005829]; myosin filament [GO:0032982]; actin binding [GO:0003779]; structural constituent of muscle [GO:0008307]; cell adhesion [GO:0007155]	
Q14409	reviewed	GLPK3_HUMAN	Glycerol kinase 3 (GK 3) (Glycerokinase 3) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 3) (Glycerol kinase 3 pseudogene) (Glycerol kinase, testis specific 1)	GK3 GK3P GKP3 GKTB	Homo sapiens (Human)	553	FUNCTION: May be involved in the regulation of glycerol uptake and metabolism. {ECO:0000305}.		glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; glycerol-3-phosphate biosynthetic process [GO:0046167]; phosphorylation [GO:0016310]; triglyceride metabolic process [GO:0006641]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; glycerol kinase activity [GO:0004370]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; glycerol kinase activity [GO:0004370]; glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; glycerol-3-phosphate biosynthetic process [GO:0046167]; phosphorylation [GO:0016310]; triglyceride metabolic process [GO:0006641]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q14439	reviewed	GP176_HUMAN	G-protein coupled receptor 176 (HB-954)	GPR176	Homo sapiens (Human)	515	FUNCTION: Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production. {ECO:0000250|UniProtKB:Q80WT4}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; circadian behavior [GO:0048512]; G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]; synapse [GO:0045202]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; synapse [GO:0045202]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; circadian behavior [GO:0048512]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80WT4}; Multi-pass membrane protein {ECO:0000255}.
Q14576	reviewed	ELAV3_HUMAN	ELAV-like protein 3 (Hu-antigen C) (HuC) (Paraneoplastic cerebellar degeneration-associated antigen) (Paraneoplastic limbic encephalitis antigen 21)	ELAVL3 HUC PLE21	Homo sapiens (Human)	367	FUNCTION: RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437). May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity). {ECO:0000250|UniProtKB:Q60900, ECO:0000269|PubMed:10710437}.		cell differentiation [GO:0030154]; nervous system development [GO:0007399]	ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR AU-rich region binding [GO:0035925]	ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]	
Q14590	reviewed	ZN235_HUMAN	Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6)	ZNF235 ZFP93 ZNF270	Homo sapiens (Human)	738	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q14593	reviewed	ZN273_HUMAN	Zinc finger protein 273 (Zinc finger protein HZF9)	ZNF273	Homo sapiens (Human)	569	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q14641	reviewed	INSL4_HUMAN	Early placenta insulin-like peptide (EPIL) (Insulin-like peptide 4) (Placentin) [Cleaved into: Early placenta insulin-like peptide B chain; Early placenta insulin-like peptide A chain]	INSL4	Homo sapiens (Human)	139	FUNCTION: May play an important role in trophoblast development and in the regulation of bone formation.		cell-cell signaling [GO:0007267]; positive regulation of chorionic trophoblast cell proliferation [GO:1901384]	extracellular space [GO:0005615]	hormone activity [GO:0005179]; insulin-like growth factor receptor binding [GO:0005159]; signaling receptor binding [GO:0005102]	extracellular space [GO:0005615]; hormone activity [GO:0005179]; insulin-like growth factor receptor binding [GO:0005159]; signaling receptor binding [GO:0005102]; cell-cell signaling [GO:0007267]; positive regulation of chorionic trophoblast cell proliferation [GO:1901384]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q14681	reviewed	KCTD2_HUMAN	BTB/POZ domain-containing protein KCTD2 (Potassium channel tetramerization domain-containing protein 2)	KCTD2 KIAA0176	Homo sapiens (Human)	263			proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]	cullin family protein binding [GO:0097602]; protein-containing complex binding [GO:0044877]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cullin family protein binding [GO:0097602]; protein-containing complex binding [GO:0044877]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]	
Q14952	reviewed	KI2S3_HUMAN	Killer cell immunoglobulin-like receptor 2DS3 (Natural killer-associated transcript 7) (NKAT-7)	KIR2DS3 NKAT7	Homo sapiens (Human)	304	FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.		cellular defense response [GO:0006968]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cellular defense response [GO:0006968]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q14C87	reviewed	T132D_HUMAN	Transmembrane protein 132D (Mature oligodendrocytes transmembrane protein) (Mature OL transmembrane protein)	TMEM132D HBE120 KIAA1944 MOLT	Homo sapiens (Human)	1099	FUNCTION: May serve as a cell-surface marker for oligodendrocyte differentiation. {ECO:0000269|PubMed:12966072}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q15034	reviewed	HERC3_HUMAN	Probable E3 ubiquitin-protein ligase HERC3 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 3) (HECT-type E3 ubiquitin transferase HERC3)	HERC3 KIAA0032	Homo sapiens (Human)	1050	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.		protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle. Note=Also found in vesicular-like structures.
Q15035	reviewed	TRAM2_HUMAN	Translocating chain-associated membrane protein 2	TRAM2 KIAA0057	Homo sapiens (Human)	370	FUNCTION: Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293). {ECO:0000269|PubMed:14749390, ECO:0000269|PubMed:27499293}.		collagen biosynthetic process [GO:0032964]; protein insertion into ER membrane [GO:0045048]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	membrane [GO:0016020]		membrane [GO:0016020]; collagen biosynthetic process [GO:0032964]; protein insertion into ER membrane [GO:0045048]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q15048	reviewed	LRC14_HUMAN	Leucine-rich repeat-containing protein 14	LRRC14 KIAA0014	Homo sapiens (Human)	493	FUNCTION: Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB. {ECO:0000269|PubMed:27426725}.		negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor signaling pathway [GO:0034122]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	kinase binding [GO:0019900]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinase binding [GO:0019900]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor signaling pathway [GO:0034122]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27426725}.
Q15181	reviewed	IPYR_HUMAN	Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)	PPA1 IOPPP PP	Homo sapiens (Human)	289			phosphate-containing compound metabolic process [GO:0006796]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]; phosphate-containing compound metabolic process [GO:0006796]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q15198	reviewed	PGFRL_HUMAN	Platelet-derived growth factor receptor-like protein (PDGFR-like protein) (PDGF receptor beta-like tumor suppressor)	PDGFRL PRLTS	Homo sapiens (Human)	375				extracellular region [GO:0005576]	platelet activating factor receptor activity [GO:0004992]; platelet-derived growth factor beta-receptor activity [GO:0005019]	extracellular region [GO:0005576]; platelet activating factor receptor activity [GO:0004992]; platelet-derived growth factor beta-receptor activity [GO:0005019]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q15238	reviewed	PSG5_HUMAN	Pregnancy-specific beta-1-glycoprotein 5 (PS-beta-G-5) (PSBG-5) (Pregnancy-specific glycoprotein 5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3)	PSG5	Homo sapiens (Human)	335			female pregnancy [GO:0007565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]	cell surface [GO:0009986]; extracellular region [GO:0005576]		cell surface [GO:0009986]; extracellular region [GO:0005576]; female pregnancy [GO:0007565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q15283	reviewed	RASA2_HUMAN	Ras GTPase-activating protein 2 (GTPase-activating protein 1m) (GAP1m)	RASA2 GAP1M RASGAP	Homo sapiens (Human)	850	FUNCTION: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).		intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580]; signal transduction [GO:0007165]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region.
Q15390	reviewed	MTFR1_HUMAN	Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region)	MTFR1 CHPPR FAM54A2 KIAA0009	Homo sapiens (Human)	333	FUNCTION: May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}.		aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Note=May be associated with the inner and the outer mitochondrial membrane. {ECO:0000250}.
Q15391	reviewed	P2Y14_HUMAN	P2Y purinoceptor 14 (P2Y14) (G-protein coupled receptor 105) (UDP-glucose receptor)	P2RY14 GPR105 KIAA0001	Homo sapiens (Human)	338	FUNCTION: Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP. {ECO:0000269|PubMed:10753868}.		G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled UDP receptor activity [GO:0045029]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled UDP receptor activity [GO:0045029]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q15404	reviewed	RSU1_HUMAN	Ras suppressor protein 1 (RSP-1) (Rsu-1)	RSU1 RSP1	Homo sapiens (Human)	277	FUNCTION: Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.		positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]		cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165]	
Q15612	reviewed	OR1Q1_HUMAN	Olfactory receptor 1Q1 (OST226) (Olfactory receptor 1Q2) (Olfactory receptor 1Q3) (Olfactory receptor 9-A) (OR9-A) (Olfactory receptor OR9-25) (Olfactory receptor TPCR106)	OR1Q1 OR1Q2 OR1Q3	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q15617	reviewed	OR8G1_HUMAN	Olfactory receptor 8G1 (Olfactory receptor OR11-281) (Olfactory receptor TPCR25)	OR8G1 OR8G1P	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q15620	reviewed	OR8B8_HUMAN	Olfactory receptor 8B8 (Olfactory receptor TPCR85) (Olfactory-like receptor JCG8)	OR8B8	Homo sapiens (Human)	311	FUNCTION: Odorant receptor (Potential). May be involved in taste perception. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q15651	reviewed	HMGN3_HUMAN	High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7)	HMGN3 TRIP7 PNAS-24	Homo sapiens (Human)	99	FUNCTION: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}.		chromatin organization [GO:0006325]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; nuclear thyroid hormone receptor binding [GO:0046966]; nucleosomal DNA binding [GO:0031492]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; nuclear thyroid hormone receptor binding [GO:0046966]; nucleosomal DNA binding [GO:0031492]; chromatin organization [GO:0006325]	SUBCELLULAR LOCATION: Nucleus.
Q15695	reviewed	U2AFL_HUMAN	Putative U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1)	ZRSR2P1 U2AF1-RS1 U2AF1L1 U2AF1P U2AF1RS1 U2AFBPL ZRSR1	Homo sapiens (Human)	479			mRNA splicing, via spliceosome [GO:0000398]	spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701]	metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]	spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701]; metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q15760	reviewed	GPR19_HUMAN	Probable G-protein coupled receptor 19 (GPR-NGA)	GPR19	Homo sapiens (Human)	415	FUNCTION: Orphan receptor.		G protein-coupled receptor signaling pathway [GO:0007186]	cilium [GO:0005929]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	cilium [GO:0005929]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q15773	reviewed	MLF2_HUMAN	Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2)	MLF2	Homo sapiens (Human)	248			regulation of DNA-templated transcription [GO:0006355]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q15847	reviewed	ADIRF_HUMAN	Adipogenesis regulatory factor (Adipogenesis factor rich in obesity) (Adipose most abundant gene transcript 2 protein) (Adipose-specific protein 2) (apM-2)	ADIRF AFRO APM2 C10orf116	Homo sapiens (Human)	76	FUNCTION: Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. {ECO:0000269|PubMed:19444912, ECO:0000269|PubMed:23239344}.		cell differentiation [GO:0030154]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell differentiation [GO:0030154]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23239344}.
Q15935	reviewed	ZNF77_HUMAN	Zinc finger protein 77 (ZNFpT1)	ZNF77	Homo sapiens (Human)	545	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q15937	reviewed	ZNF79_HUMAN	Zinc finger protein 79 (ZNFpT7)	ZNF79	Homo sapiens (Human)	498	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q16378	reviewed	PROL4_HUMAN	Proline-rich protein 4 (Lacrimal proline-rich protein) (Nasopharyngeal carcinoma-associated proline-rich protein 4)	PRR4 LPRP PROL4	Homo sapiens (Human)	134			retina homeostasis [GO:0001895]; visual perception [GO:0007601]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Secreted.
Q16538	reviewed	GP162_HUMAN	Probable G-protein coupled receptor 162 (Gene-rich cluster gene A protein)	GPR162 GRCA	Homo sapiens (Human)	588	FUNCTION: Orphan receptor.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q16557	reviewed	PSG3_HUMAN	Pregnancy-specific beta-1-glycoprotein 3 (PS-beta-G-3) (PSBG-3) (Pregnancy-specific glycoprotein 3) (Carcinoembryonic antigen SG5)	PSG3	Homo sapiens (Human)	428			defense response [GO:0006952]; female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	protein tyrosine kinase binding [GO:1990782]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein tyrosine kinase binding [GO:1990782]; defense response [GO:0006952]; female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q16589	reviewed	CCNG2_HUMAN	Cyclin-G2	CCNG2	Homo sapiens (Human)	344	FUNCTION: May play a role in growth regulation and in negative regulation of cell cycle progression.		cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772]; regulation of cell cycle [GO:0051726]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q16661	reviewed	GUC2B_HUMAN	Guanylate cyclase activator 2B [Cleaved into: Guanylate cyclase C-activating peptide 2 (Guanylate cyclase C-activating peptide II) (GCAP-II); Uroguanylin (UGN)]	GUCA2B	Homo sapiens (Human)	112	FUNCTION: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.		cGMP-mediated signaling [GO:0019934]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	guanylate cyclase activator activity [GO:0030250]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; guanylate cyclase activator activity [GO:0030250]; cGMP-mediated signaling [GO:0019934]	SUBCELLULAR LOCATION: Secreted.
Q17RB0	reviewed	RTL8B_HUMAN	Retrotransposon Gag-like protein 8B (Mammalian retrotransposon derived protein 8B)	RTL8B CXX1C FAM127C MAR8B	Homo sapiens (Human)	113		MISCELLANEOUS: RTL8B is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. {ECO:0000269|PubMed:16093683}.					
Q17RF5	reviewed	ODAPH_HUMAN	Odontogenesis associated phosphoprotein	ODAPH C4orf26	Homo sapiens (Human)	130	FUNCTION: May promote nucleation of hydroxyapatite. {ECO:0000269|PubMed:22901946}.		positive regulation of biomineral tissue development [GO:0070169]; positive regulation of enamel mineralization [GO:0070175]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of enamel mineralization [GO:0070175]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q17RN3	reviewed	FA98C_HUMAN	Protein FAM98C	FAM98C	Homo sapiens (Human)	349				tRNA-splicing ligase complex [GO:0072669]		tRNA-splicing ligase complex [GO:0072669]	
Q17RY6	reviewed	LY6K_HUMAN	Lymphocyte antigen 6K (Ly-6K)	LY6K CO16	Homo sapiens (Human)	165	FUNCTION: Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth (PubMed:18089789). {ECO:0000250|UniProtKB:Q9CWP4, ECO:0000269|PubMed:18089789}.		binding of sperm to zona pellucida [GO:0007339]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; binding of sperm to zona pellucida [GO:0007339]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18089789}. Cytoplasm {ECO:0000269|PubMed:18089789}. Cell membrane {ECO:0000250|UniProtKB:Q9CWP4}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9CWP4}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9CWP4}. Membrane raft {ECO:0000250|UniProtKB:Q9CWP4}.
Q1L6U9	reviewed	MSMP_HUMAN	Prostate-associated microseminoprotein (PC3-secreted microprotein)	MSMP PSMP	Homo sapiens (Human)	139	FUNCTION: Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:24442440). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:24442440). Exhibits a chemotactic activity for monocytes and lymphocytes but not neutrophils (PubMed:24442440). {ECO:0000269|PubMed:24442440}.		inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	CCR2 chemokine receptor binding [GO:0031727]; cytokine activity [GO:0005125]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; CCR2 chemokine receptor binding [GO:0031727]; cytokine activity [GO:0005125]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17338636, ECO:0000269|PubMed:24442440}.
Q1ZZU3	reviewed	SWI5_HUMAN	DNA repair protein SWI5 homolog (HBV DNAPTP1-transactivated protein A) (Protein SAE3 homolog)	SWI5 C9orf119 SAE3	Homo sapiens (Human)	235	FUNCTION: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. {ECO:0000269|PubMed:21252223}.		cellular response to ionizing radiation [GO:0071479]; double-strand break repair via homologous recombination [GO:0000724]	nucleus [GO:0005634]; Swi5-Sfr1 complex [GO:0032798]; Swi5-Swi2 complex [GO:0034974]		nucleus [GO:0005634]; Swi5-Sfr1 complex [GO:0032798]; Swi5-Swi2 complex [GO:0034974]; cellular response to ionizing radiation [GO:0071479]; double-strand break repair via homologous recombination [GO:0000724]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q2KJY2	reviewed	KI26B_HUMAN	Kinesin-like protein KIF26B	KIF26B	Homo sapiens (Human)	2108	FUNCTION: Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}.		establishment of cell polarity [GO:0030010]; microtubule-based movement [GO:0007018]; positive regulation of cell-cell adhesion [GO:0022409]; ureteric bud invasion [GO:0072092]	cytoplasm [GO:0005737]; microtubule [GO:0005874]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; establishment of cell polarity [GO:0030010]; microtubule-based movement [GO:0007018]; positive regulation of cell-cell adhesion [GO:0022409]; ureteric bud invasion [GO:0072092]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000305}.
Q2L4Q9	reviewed	PRS53_HUMAN	Serine protease 53 (EC 3.4.21.-) (Polyserine protease 3) (Polyserase-3)	PRSS53	Homo sapiens (Human)	553	FUNCTION: In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator. {ECO:0000269|PubMed:16566820}.		proteolysis [GO:0006508]	extracellular region [GO:0005576]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16566820}.
Q2M1V0	reviewed	ISX_HUMAN	Intestine-specific homeobox (RAX-like homeobox)	ISX RAXLX	Homo sapiens (Human)	245	FUNCTION: Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine (By similarity). {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q2M2H8	reviewed	MGAL_HUMAN	Probable maltase-glucoamylase 2 (Maltase-glucoamylase (alpha-glucosidase) pseudogene) [Includes: Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha-glucosidase)]	MGAM2	Homo sapiens (Human)	2515			carbohydrate metabolic process [GO:0005975]	membrane [GO:0016020]	alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]; glucan 1,4-alpha-glucosidase activity [GO:0004339]	membrane [GO:0016020]; alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]; glucan 1,4-alpha-glucosidase activity [GO:0004339]; carbohydrate metabolic process [GO:0005975]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q2M3G4	reviewed	SHRM1_HUMAN	Protein Shroom1 (Apical protein 2)	SHROOM1 APXL2 KIAA1960	Homo sapiens (Human)	852	FUNCTION: May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}.		actin filament bundle assembly [GO:0051017]; cell morphogenesis [GO:0000902]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cortical actin cytoskeleton [GO:0030864]; microtubule [GO:0005874]	actin filament binding [GO:0051015]; myosin II binding [GO:0045159]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cortical actin cytoskeleton [GO:0030864]; microtubule [GO:0005874]; actin filament binding [GO:0051015]; myosin II binding [GO:0045159]; actin filament bundle assembly [GO:0051017]; cell morphogenesis [GO:0000902]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q2M3X9	reviewed	ZN674_HUMAN	Zinc finger protein 674	ZNF674	Homo sapiens (Human)	581	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q2MJR0	reviewed	SPRE3_HUMAN	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3)	SPRED3 EVE-3	Homo sapiens (Human)	410	FUNCTION: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q6P6N5}.		negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	plasma membrane [GO:0005886]	protein kinase binding [GO:0019901]	plasma membrane [GO:0005886]; protein kinase binding [GO:0019901]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6P6N5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6P6N5}.
Q2NKX9	reviewed	CB068_HUMAN	UPF0561 protein C2orf68	C2orf68	Homo sapiens (Human)	166							
Q2NL82	reviewed	TSR1_HUMAN	Pre-rRNA-processing protein TSR1 homolog	TSR1 KIAA1401	Homo sapiens (Human)	804	FUNCTION: Required during maturation of the 40S ribosomal subunit in the nucleolus. {ECO:0000250}.		endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511]; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
Q2NL98	reviewed	VMAC_HUMAN	Vimentin-type intermediate filament-associated coiled-coil protein	VMAC	Homo sapiens (Human)	169				cytoplasm [GO:0005737]; type III intermediate filament [GO:0045098]		cytoplasm [GO:0005737]; type III intermediate filament [GO:0045098]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Colocalizes with vimentin-type intermediate filaments. {ECO:0000250}.
Q2T9K0	reviewed	TMM44_HUMAN	Transmembrane protein 44	TMEM44	Homo sapiens (Human)	475				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q2T9L4	reviewed	INSY1_HUMAN	Inhibitory synaptic factor 1 (InSyn1)	INSYN1 C15orf59	Homo sapiens (Human)	293	FUNCTION: Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. {ECO:0000250|UniProtKB:Q8CD60}.		inhibitory postsynaptic potential [GO:0060080]	postsynaptic density [GO:0014069]		postsynaptic density [GO:0014069]; inhibitory postsynaptic potential [GO:0060080]	SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250|UniProtKB:Q8CD60}.
Q2TAC6	reviewed	KIF19_HUMAN	Kinesin-like protein KIF19	KIF19	Homo sapiens (Human)	998	FUNCTION: Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Due to intron retention. {ECO:0000305}.	axonemal microtubule depolymerization [GO:0060404]; microtubule-based movement [GO:0007018]; plus-end specific microtubule depolymerization [GO:0070462]	axoneme [GO:0005930]; cilium [GO:0005929]; kinesin complex [GO:0005871]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]	axoneme [GO:0005930]; cilium [GO:0005929]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]; axonemal microtubule depolymerization [GO:0060404]; microtubule-based movement [GO:0007018]; plus-end specific microtubule depolymerization [GO:0070462]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Note=Localizes to cilia tips. {ECO:0000250}.
Q2TAP0	reviewed	GOG7B_HUMAN	Golgin subfamily A member 7B	GOLGA7B C10orf132 C10orf133	Homo sapiens (Human)	167	FUNCTION: Play a role in cell adhesion by regulating the plasma membrane localization of the palmitoyltransferase ZDHHC5 (PubMed:31402609). May be involved in protein transport from Golgi to cell surface. {ECO:0000269|PubMed:31402609}.	MISCELLANEOUS: Shares an exon with the neighboring tail-to-tail oriented gene CRTAC1.	protein targeting to membrane [GO:0006612]	Golgi membrane [GO:0000139]; palmitoyltransferase complex [GO:0002178]; plasma membrane [GO:0005886]	enzyme binding [GO:0019899]	Golgi membrane [GO:0000139]; palmitoyltransferase complex [GO:0002178]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31402609}. Golgi apparatus membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Q2TBC4	reviewed	PRIC4_HUMAN	Prickle-like protein 4 (Overexpressed breast tumor protein)	PRICKLE4 C6orf49 OEBT	Homo sapiens (Human)	344			actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]	adherens junction [GO:0005912]; filamentous actin [GO:0031941]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; muscle alpha-actinin binding [GO:0051371]; zinc ion binding [GO:0008270]	adherens junction [GO:0005912]; filamentous actin [GO:0031941]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; muscle alpha-actinin binding [GO:0051371]; zinc ion binding [GO:0008270]; actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]	
Q2VIR3	reviewed	IF2GL_HUMAN	Eukaryotic translation initiation factor 2 subunit 3B (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma A) (eIF-2-gamma A) (eIF-2gA)	EIF2S3B	Homo sapiens (Human)	472	FUNCTION: Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198}.		formation of translation preinitiation complex [GO:0001731]	eukaryotic translation initiation factor 2 complex [GO:0005850]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049]	eukaryotic translation initiation factor 2 complex [GO:0005850]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049]; formation of translation preinitiation complex [GO:0001731]	
Q2VPB7	reviewed	AP5B1_HUMAN	AP-5 complex subunit beta-1 (Adaptor-related protein complex 5 beta subunit) (Beta5)	AP5B1 PP1030	Homo sapiens (Human)	878	FUNCTION: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. {ECO:0000269|PubMed:22022230}.		endosomal transport [GO:0016197]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]		AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	
Q2VWP7	reviewed	PRTG_HUMAN	Protogenin (Protein Shen-Dan)	PRTG	Homo sapiens (Human)	1150	FUNCTION: May play a role in anteroposterior axis elongation. {ECO:0000250|UniProtKB:Q2EY15}.		cell-cell adhesion [GO:0098609]; negative regulation of neurogenesis [GO:0050768]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; cell-cell adhesion [GO:0098609]; negative regulation of neurogenesis [GO:0050768]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q30KP8	reviewed	DB136_HUMAN	Defensin beta 136 (Beta-defensin 136) (DEFB137)	DEFB136	Homo sapiens (Human)	78	FUNCTION: Host defense peptide that exhibits antibacterial and antifungal activity (PubMed:34481960). Exhibits antimicrobial activity against E.coli, S.aureus and C.albicans (in vitro) (PubMed:34481960). Has high lipopolysaccharide (LPS)-binding affinity, and may thereby be involved in immunoregulation through LPS neutralization (PubMed:34481960). {ECO:0000269|PubMed:34481960}.		antibacterial innate immune response [GO:0140367]; antifungal innate immune response [GO:0061760]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; killing of cells of another organism [GO:0031640]	extracellular region [GO:0005576]	lipopolysaccharide binding [GO:0001530]	extracellular region [GO:0005576]; lipopolysaccharide binding [GO:0001530]; antibacterial innate immune response [GO:0140367]; antifungal innate immune response [GO:0061760]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; killing of cells of another organism [GO:0031640]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}.
Q30KQ9	reviewed	DB110_HUMAN	Beta-defensin 110 (Beta-defensin 10) (DEFB-10) (Beta-defensin 11) (DEFB-11) (Beta-defensin 111) (Defensin, beta 110) (Defensin, beta 111)	DEFB110 DEFB10 DEFB11 DEFB111	Homo sapiens (Human)	67	FUNCTION: Has antibacterial activity. {ECO:0000250}.		cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular space [GO:0005615]	CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]	extracellular space [GO:0005615]; CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]; cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q32M78	reviewed	ZN699_HUMAN	Zinc finger protein 699 (Hangover homolog)	ZNF699	Homo sapiens (Human)	642	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q32MH5	reviewed	ATOSA_HUMAN	Atos homolog protein A	ATOSA FAM214A KIAA1370	Homo sapiens (Human)	1076	FUNCTION: Transcription regulator that syncronizes transcriptional and translational programs to promote macrophage invasion of tissues. {ECO:0000250|UniProtKB:Q69ZK7}.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7JXG9}.
Q32ZL2	reviewed	PLPR5_HUMAN	Phospholipid phosphatase-related protein type 5 (Lipid phosphate phosphatase-related protein type 5) (Phosphatidic acid phosphatase type 2d) (Plasticity-related gene 5 protein) (PRG-5)	PLPPR5 LPPR5 PAP2D PRG5	Homo sapiens (Human)	321	FUNCTION: Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction. {ECO:0000250|UniProtKB:Q8BJ52}.		phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of neuron projection development [GO:0010976]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	phosphatidate phosphatase activity [GO:0008195]	plasma membrane [GO:0005886]; phosphatidate phosphatase activity [GO:0008195]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of neuron projection development [GO:0010976]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BJ52}; Multi-pass membrane protein {ECO:0000255}.
Q3B726	reviewed	RPA43_HUMAN	DNA-directed RNA polymerase I subunit RPA43 (DNA-directed RNA polymerase I subunit F) (Twist neighbor protein)	POLR1F TWISTNB	Homo sapiens (Human)	338	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.		cellular response to leukemia inhibitory factor [GO:1990830]; DNA-templated transcription initiation [GO:0006352]	nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]		nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA-templated transcription initiation [GO:0006352]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
Q3B8N2	reviewed	LEG9B_HUMAN	Galectin-9B (Gal-9B) (Galectin-9-like protein A)	LGALS9B	Homo sapiens (Human)	356	FUNCTION: Binds galactosides. {ECO:0000250}.	MISCELLANEOUS: The LGALS9-like proteins are encoded by a duplicated regions on chromosome 17; there are at least 3 genes coding for galectin-9-like proteins.	negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of type II interferon production [GO:0032689]; positive regulation of gene expression [GO:0010628]	cytosol [GO:0005829]; nucleus [GO:0005634]	carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936]	cytosol [GO:0005829]; nucleus [GO:0005634]; carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of type II interferon production [GO:0032689]; positive regulation of gene expression [GO:0010628]	
Q3BBV0	reviewed	NBPF1_HUMAN	Neuroblastoma breakpoint family member 1	NBPF1 KIAA1693	Homo sapiens (Human)	1214		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16079250}.
Q3I5F7	reviewed	ACOT6_HUMAN	Acyl-coenzyme A thioesterase 6 (Acyl-CoA thioesterase 6) (EC 3.1.2.-)	ACOT6 C14orf42	Homo sapiens (Human)	421	FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Catalyzes the hydrolysis of phytanoyl-CoA and pristanoyl-CoA, two methyl-branched fatty acids derived from phytol, that enter the body via the diet. {ECO:0000250|UniProtKB:Q32Q92}.		acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]	acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]	SUBCELLULAR LOCATION: [Isoform 1]: Peroxisome {ECO:0000305|PubMed:16940157}. Note=Localization to the peroxisome is uncertain since the potential C-terminal peroxisome targeting signal found in the mouse ortholog is not perfectly conserved. {ECO:0000305|PubMed:16940157}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305|PubMed:16940157}. Note=Recombinant N-terminally GFP-tagged protein localizes to the cytosol. {ECO:0000305|PubMed:16940157}.
Q3KNT9	reviewed	TMM95_HUMAN	Sperm-egg fusion protein TMEM95 (Transmembrane protein 95)	TMEM95 UNQ9390/PRO34281	Homo sapiens (Human)	176	FUNCTION: Sperm protein required for fusion of sperm with the egg membrane during fertilization. {ECO:0000250|UniProtKB:P0DJF3}.		fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	acrosomal membrane [GO:0002080]; sperm plasma membrane [GO:0097524]		acrosomal membrane [GO:0002080]; sperm plasma membrane [GO:0097524]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P0DJF3}; Single-pass type I membrane protein {ECO:0000305}. Note=Following the acrosome reaction, relocalizes to the equatorial segment. {ECO:0000250|UniProtKB:P0DJF3}.
Q3KPI0	reviewed	CEA21_HUMAN	Carcinoembryonic antigen-related cell adhesion molecule 21	CEACAM21 UNQ3098/PRO10075	Homo sapiens (Human)	293			T cell activation [GO:0042110]	external side of plasma membrane [GO:0009897]		external side of plasma membrane [GO:0009897]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q3KQU3	reviewed	MA7D1_HUMAN	MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1)	MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464	Homo sapiens (Human)	841			microtubule cytoskeleton organization [GO:0000226]	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819]		cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819]; microtubule cytoskeleton organization [GO:0000226]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15561729}.
Q3LI77	reviewed	KR134_HUMAN	Keratin-associated protein 13-4	KRTAP13-4 KAP13.4	Homo sapiens (Human)	160	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3MIN7	reviewed	RGL3_HUMAN	Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3)	RGL3	Homo sapiens (Human)	710	FUNCTION: Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}.		Ras protein signal transduction [GO:0007265]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; Ras protein signal transduction [GO:0007265]	
Q3MIW9	reviewed	MUCL3_HUMAN	Mucin-like protein 3 (Diffuse panbronchiolitis critical region protein 1)	MUCL3 C6orf37 DPCR1 PBLT	Homo sapiens (Human)	517	FUNCTION: May modulate NF-kappaB signaling and play a role in cell growth. {ECO:0000269|PubMed:29242154}.			cytoplasm [GO:0005737]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29242154}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:29242154}.
Q3MJ13	reviewed	WDR72_HUMAN	WD repeat-containing protein 72	WDR72	Homo sapiens (Human)	1102	FUNCTION: Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. {ECO:0000250|UniProtKB:D3YYM4, ECO:0000269|PubMed:19853237, ECO:0000269|PubMed:25008349}.		enamel mineralization [GO:0070166]; extracellular matrix disassembly [GO:0022617]; protein localization to plasma membrane [GO:0072659]	cytoplasm [GO:0005737]; endosome [GO:0005768]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; endosome [GO:0005768]; nucleus [GO:0005634]; enamel mineralization [GO:0070166]; extracellular matrix disassembly [GO:0022617]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:D3YYM4}.
Q3SX64	reviewed	CMA1D_HUMAN	Protein CIMAP1D (CIMAP1 family member D) (Outer dense fiber protein 3-like protein 2)	CIMAP1D C19orf19 ODF3L2	Homo sapiens (Human)	289				cytoplasmic microtubule [GO:0005881]; cytoskeleton [GO:0005856]		cytoplasmic microtubule [GO:0005881]; cytoskeleton [GO:0005856]	
Q3SY17	reviewed	S2552_HUMAN	Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A52 (Mitochondrial NAD(+) transporter SLC25A52) (Mitochondrial carrier triple repeat protein 2) (Solute carrier family 25 member 52)	SLC25A52 MCART2	Homo sapiens (Human)	297	FUNCTION: Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria (PubMed:32906142). Compared to SLC25A51, SLC25A52-mediated transport is not essential for the import of NAD(+) in mitochondria (PubMed:32906142). The transport mechanism, uniport or antiport, its electrogenicity and substrate selectivity, remain to be elucidated. {ECO:0000269|PubMed:32906142}.		mitochondrial NAD transmembrane transport [GO:1990549]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	NAD transmembrane transporter activity [GO:0051724]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; NAD transmembrane transporter activity [GO:0051724]; mitochondrial NAD transmembrane transport [GO:1990549]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:32906142}; Multi-pass membrane protein {ECO:0000255}.
Q3SY52	reviewed	ZIK1_HUMAN	Zinc finger protein interacting with ribonucleoprotein K (Zinc finger protein 762)	ZIK1 ZNF762	Homo sapiens (Human)	487	FUNCTION: May be a transcriptional repressor. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q3SY77	reviewed	UD3A2_HUMAN	UDP-glucuronosyltransferase 3A2 (UDPGT 3A2) (EC 2.4.1.17)	UGT3A2 PSEC0073 UNQ842/PRO1780	Homo sapiens (Human)	523	FUNCTION: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). {ECO:0000250}.		cellular response to genistein [GO:0071412]	UDP-N-acetylglucosamine transferase complex [GO:0043541]	glucuronosyltransferase activity [GO:0015020]; UDP-glycosyltransferase activity [GO:0008194]	UDP-N-acetylglucosamine transferase complex [GO:0043541]; glucuronosyltransferase activity [GO:0015020]; UDP-glycosyltransferase activity [GO:0008194]; cellular response to genistein [GO:0071412]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q3T8J9	reviewed	GON4L_HUMAN	GON-4-like protein (GON-4 homolog)	GON4L GON4 KIAA1606	Homo sapiens (Human)	2241	FUNCTION: Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}.		regulation of DNA-templated transcription [GO:0006355]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coregulator activity [GO:0003712]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coregulator activity [GO:0003712]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810}.
Q3ZCN5	reviewed	OTOGL_HUMAN	Otogelin-like protein	OTOGL C12orf64	Homo sapiens (Human)	2353			L-arabinose metabolic process [GO:0046373]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	alpha-L-arabinofuranosidase activity [GO:0046556]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; alpha-L-arabinofuranosidase activity [GO:0046556]; L-arabinose metabolic process [GO:0046373]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q3ZCQ3	reviewed	F174B_HUMAN	Membrane protein FAM174B	FAM174B	Homo sapiens (Human)	159	FUNCTION: Essential for Golgi structural integrity. {ECO:0000269|PubMed:29851555}.		Golgi organization [GO:0007030]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]		Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; Golgi organization [GO:0007030]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29851555}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:29851555}.
Q3ZCT1	reviewed	ZN260_HUMAN	Zinc finger protein 260 (Zfp-260)	ZNF260 ZFP260	Homo sapiens (Human)	412	FUNCTION: Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity). {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16166646}.
Q3ZCX4	reviewed	ZN568_HUMAN	Zinc finger protein 568	ZNF568	Homo sapiens (Human)	644	FUNCTION: Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells. {ECO:0000250|UniProtKB:E9PYI1}.		embryonic placenta morphogenesis [GO:0060669]; in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; embryonic placenta morphogenesis [GO:0060669]; in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:E9PYI1}.
Q495N2	reviewed	S36A3_HUMAN	Proton-coupled amino acid transporter 3 (Proton/amino acid transporter 3) (Solute carrier family 36 member 3) (Tramdorin-2)	SLC36A3 PAT3 TRAMD2	Homo sapiens (Human)	470			glycine transport [GO:0015816]; L-alanine transport [GO:0015808]; proline transmembrane transport [GO:0035524]; proton transmembrane transport [GO:1902600]	vacuolar membrane [GO:0005774]	amino acid:proton symporter activity [GO:0005280]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]	vacuolar membrane [GO:0005774]; amino acid:proton symporter activity [GO:0005280]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; glycine transport [GO:0015816]; L-alanine transport [GO:0015808]; proline transmembrane transport [GO:0035524]; proton transmembrane transport [GO:1902600]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q495X7	reviewed	TRI60_HUMAN	Tripartite motif-containing protein 60 (RING finger protein 129) (RING finger protein 33)	TRIM60 RNF129 RNF33	Homo sapiens (Human)	471	FUNCTION: E3 SUMO-protein ligase that mediates SUMOylation of TAB2 leading to inhibition of NF-kappa-B and MAPK pathways by suppressing the TRAF6/TAB2/TAK1 complex. {ECO:0000269|PubMed:33184450}.		negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	SUMO-ubiquitin ligase activity [GO:0140082]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; SUMO-ubiquitin ligase activity [GO:0140082]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; protein ubiquitination [GO:0016567]	
Q496Y0	reviewed	LONF3_HUMAN	LON peptidase N-terminal domain and RING finger protein 3 (RING finger protein 127)	LONRF3 RNF127	Homo sapiens (Human)	759				cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	
Q49AH0	reviewed	CDNF_HUMAN	Cerebral dopamine neurotrophic factor (ARMET-like protein 1) (Conserved dopamine neurotrophic factor)	CDNF ARMETL1	Homo sapiens (Human)	187	FUNCTION: Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity). {ECO:0000250}.		dopaminergic neuron differentiation [GO:0071542]; neuron projection development [GO:0031175]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]	growth factor activity [GO:0008083]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; growth factor activity [GO:0008083]; dopaminergic neuron differentiation [GO:0071542]; neuron projection development [GO:0031175]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17611540, ECO:0000269|PubMed:18561914}.
Q49B96	reviewed	COX19_HUMAN	Cytochrome c oxidase assembly protein COX19 (hCOX19)	COX19	Homo sapiens (Human)	90	FUNCTION: Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis (PubMed:23345593). May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity). {ECO:0000250|UniProtKB:Q3E731, ECO:0000269|PubMed:23345593}.		intracellular copper ion homeostasis [GO:0006878]; mitochondrial cytochrome c oxidase assembly [GO:0033617]	cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; intracellular copper ion homeostasis [GO:0006878]; mitochondrial cytochrome c oxidase assembly [GO:0033617]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16212937, ECO:0000269|PubMed:23345593, ECO:0000269|PubMed:23676665}. Mitochondrion intermembrane space {ECO:0000269|PubMed:23345593, ECO:0000269|PubMed:23676665}. Mitochondrion {ECO:0000269|PubMed:23345593, ECO:0000269|PubMed:23676665}. Note=Partitions between mitochondria and the cytosol in a copper-dependent manner. Enriched in the cytosol when intracellular copper concentrations are elevated. {ECO:0000269|PubMed:23345593}.
Q49SQ1	reviewed	GPR33_HUMAN	Probable G-protein coupled receptor 33	GPR33	Homo sapiens (Human)	333	FUNCTION: Orphan receptor; could be a chemoattractant receptor.		complement receptor mediated signaling pathway [GO:0002430]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	plasma membrane [GO:0005886]	complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; complement receptor mediated signaling pathway [GO:0002430]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q4G0A6	reviewed	MINY4_HUMAN	Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (EC 3.4.19.12) (Probable deubiquitinating enzyme MINDY-4)	MINDY4 C7orf67 FAM188B	Homo sapiens (Human)	757	FUNCTION: Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000250|UniProtKB:Q8NBR6}.		proteolysis [GO:0006508]		cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]	cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; proteolysis [GO:0006508]	
Q4G0T1	reviewed	SRCRM_HUMAN	Scavenger receptor cysteine-rich domain-containing protein SCART1 (Scavenger receptor family member expressed on T cells 1)	SCART1	Homo sapiens (Human)	1027	FUNCTION: May play a role in the immune system, perhaps as a co-receptor on alphabeta and gammadelta T-cells. {ECO:0000305|PubMed:22795646}.		T cell mediated immunity [GO:0002456]	brush border [GO:0005903]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]		brush border [GO:0005903]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; T cell mediated immunity [GO:0002456]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q4G148	reviewed	GXLT1_HUMAN	Glucoside xylosyltransferase 1 (EC 2.4.2.42) (Glycosyltransferase 8 domain-containing protein 3)	GXYLT1 GLT8D3	Homo sapiens (Human)	440	FUNCTION: Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose. {ECO:0000269|PubMed:19940119}.		O-glycan processing [GO:0016266]	membrane [GO:0016020]	UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity [GO:0140563]; UDP-xylosyltransferase activity [GO:0035252]	membrane [GO:0016020]; UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity [GO:0140563]; UDP-xylosyltransferase activity [GO:0035252]; O-glycan processing [GO:0016266]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q4G1C9	reviewed	GRPL2_HUMAN	GLIPR1-like protein 2	GLIPR1L2	Homo sapiens (Human)	344				extracellular space [GO:0005615]; membrane [GO:0016020]		extracellular space [GO:0005615]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q4LEZ3	reviewed	AARD_HUMAN	Alanine and arginine-rich domain-containing protein	AARD C8orf85	Homo sapiens (Human)	155							
Q4U2R6	reviewed	RM51_HUMAN	Large ribosomal subunit protein mL51 (39S ribosomal protein L51, mitochondrial) (L51mt) (MRP-L51) (bMRP-64) (bMRP64)	MRPL51 MRP64 CDA09 HSPC241	Homo sapiens (Human)	128			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q4VC05	reviewed	BCL7A_HUMAN	B-cell CLL/lymphoma 7 protein family member A	BCL7A	Homo sapiens (Human)	210			chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; SWI/SNF complex [GO:0016514]		chromatin [GO:0000785]; GBAF complex [GO:0140288]; SWI/SNF complex [GO:0016514]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q4VNC0	reviewed	AT135_HUMAN	Probable cation-transporting ATPase 13A5 (EC 7.2.2.-) (P5-ATPase isoform 5)	ATP13A5 UNQ488/PRO1004	Homo sapiens (Human)	1218			intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; polyamine transmembrane transport [GO:1902047]	late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; polyamine transmembrane transporter activity [GO:0015203]	late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; polyamine transmembrane transporter activity [GO:0015203]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; polyamine transmembrane transport [GO:1902047]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q4VX76	reviewed	SYTL3_HUMAN	Synaptotagmin-like protein 3 (Exophilin-6)	SYTL3 SLP3	Homo sapiens (Human)	610	FUNCTION: May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). {ECO:0000250}.		exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]	exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]	calcium-dependent phospholipid binding [GO:0005544]; neurexin family protein binding [GO:0042043]; small GTPase binding [GO:0031267]	exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; calcium-dependent phospholipid binding [GO:0005544]; neurexin family protein binding [GO:0042043]; small GTPase binding [GO:0031267]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q4ZIN3	reviewed	MBRL_HUMAN	Membralin (Transmembrane protein 259)	TMEM259 C19orf6	Homo sapiens (Human)	620	FUNCTION: May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress. {ECO:0000250|UniProtKB:Q8CIV2}.		positive regulation of ERAD pathway [GO:1904294]; response to endoplasmic reticulum stress [GO:0034976]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; positive regulation of ERAD pathway [GO:1904294]; response to endoplasmic reticulum stress [GO:0034976]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8CIV2}; Multi-pass membrane protein {ECO:0000255}.
Q504T8	reviewed	MIDN_HUMAN	Midnolin (Midbrain nucleolar protein)	MIDN	Homo sapiens (Human)	468	FUNCTION: Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion. {ECO:0000250|UniProtKB:D4AE48, ECO:0000250|UniProtKB:Q3TPJ7}.		negative regulation of glucokinase activity [GO:0033132]; negative regulation of insulin secretion [GO:0046676]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]	kinase binding [GO:0019900]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; kinase binding [GO:0019900]; negative regulation of glucokinase activity [GO:0033132]; negative regulation of insulin secretion [GO:0046676]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q3TPJ7}. Nucleus {ECO:0000269|PubMed:24187134}. Cytoplasm, cytosol {ECO:0000269|PubMed:24187134}. Note=Detected in the nucleus and nucleolus with no expression in the cytoplasm (By similarity). However, a later study finds expression in the nucleus and cytoplasm with no expression in the nucleolus (PubMed:24187134). {ECO:0000250|UniProtKB:Q3TPJ7, ECO:0000269|PubMed:24187134}.
Q52LR7	reviewed	EPC2_HUMAN	Enhancer of polycomb homolog 2 (EPC-like)	EPC2	Homo sapiens (Human)	807	FUNCTION: May play a role in transcription or DNA repair. {ECO:0000250}.		chromatin organization [GO:0006325]; DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357]	NuA4 histone acetyltransferase complex [GO:0035267]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Piccolo NuA4 histone acetyltransferase complex [GO:0032777]		NuA4 histone acetyltransferase complex [GO:0035267]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Piccolo NuA4 histone acetyltransferase complex [GO:0032777]; chromatin organization [GO:0006325]; DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q52MB2	reviewed	CC184_HUMAN	Coiled-coil domain-containing protein 184	CCDC184 C12orf68	Homo sapiens (Human)	194				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q52WX2	reviewed	SBK1_HUMAN	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3 domain-binding kinase 1)	SBK1	Homo sapiens (Human)	424	FUNCTION: May be involved in signal-transduction pathways related to the control of brain development. {ECO:0000250}.		phosphorylation [GO:0016310]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q53G44	reviewed	IF44L_HUMAN	Interferon-induced protein 44-like	IFI44L C1orf29 GS3686	Homo sapiens (Human)	452	FUNCTION: Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity (PubMed:34722780). During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion (PubMed:34722780). Plays a role in the control of respiratory syncytial virus/RSV infection, reducing the ability of the virus to replicate (PubMed:32611756). Exhibits a low antiviral activity against hepatitis C virus (PubMed:21478870). Acts also as a feedback regulator of IFN responses by negatively regulating IKBKB and IKBKE kinase activities through interaction with FKBP5 (PubMed:31434731). {ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:31434731, ECO:0000269|PubMed:32611756, ECO:0000269|PubMed:34722780}.		defense response to virus [GO:0051607]; immune response [GO:0006955]	cytoplasm [GO:0005737]	GTP binding [GO:0005525]	cytoplasm [GO:0005737]; GTP binding [GO:0005525]; defense response to virus [GO:0051607]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q53GI3	reviewed	ZN394_HUMAN	Zinc finger protein 394 (Zinc finger protein with KRAB and SCAN domains 14)	ZNF394 ZKSCAN14	Homo sapiens (Human)	561	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q53HC5	reviewed	KLH26_HUMAN	Kelch-like protein 26	KLHL26	Homo sapiens (Human)	615							
Q53QW1	reviewed	TEX44_HUMAN	Testis-expressed protein 44	TEX44 C2orf57	Homo sapiens (Human)	395				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26168773}.
Q53RD9	reviewed	FBLN7_HUMAN	Fibulin-7 (FIBL-7)	FBLN7 TM14	Homo sapiens (Human)	439	FUNCTION: An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation. {ECO:0000250}.		cell adhesion [GO:0007155]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]	calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q53T59	reviewed	H1BP3_HUMAN	HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3)	HS1BP3	Homo sapiens (Human)	392	FUNCTION: May be a modulator of IL-2 signaling. {ECO:0000250}.		regulation of apoptotic process [GO:0042981]	endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]	phosphatidylinositol binding [GO:0035091]	endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; phosphatidylinositol binding [GO:0035091]; regulation of apoptotic process [GO:0042981]	
Q562R1	reviewed	ACTBL_HUMAN	Beta-actin-like protein 2 (Kappa-actin)	ACTBL2	Homo sapiens (Human)	376	FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}.	MISCELLANEOUS: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.	axonogenesis [GO:0007409]; cell motility [GO:0048870]	actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]	ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]	actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; axonogenesis [GO:0007409]; cell motility [GO:0048870]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q567V2	reviewed	M17L2_HUMAN	Mpv17-like protein 2	MPV17L2 FKSG24	Homo sapiens (Human)	206	FUNCTION: Required for the assembly and stability of the mitochondrial ribosome (PubMed:24948607). Is a positive regulator of mitochondrial protein synthesis (PubMed:24948607). {ECO:0000269|PubMed:24948607}.		cellular response to reactive oxygen species [GO:0034614]; mitochondrial ribosome assembly [GO:0061668]; positive regulation of mitochondrial translation [GO:0070131]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]		cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; cellular response to reactive oxygen species [GO:0034614]; mitochondrial ribosome assembly [GO:0061668]; positive regulation of mitochondrial translation [GO:0070131]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion inner membrane {ECO:0000269|PubMed:24948607}.
Q569H4	reviewed	LARGN_HUMAN	Protein Largen (Mesenchymal stem cell protein DSC54) (Proline-rich protein 16)	PRR16	Homo sapiens (Human)	304	FUNCTION: Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration. {ECO:0000269|PubMed:24656129}.	MISCELLANEOUS: Was named 'Largen' because overexpression causes cells enlargement. {ECO:0000305|PubMed:24656129}.	positive regulation of cell size [GO:0045793]; positive regulation of translation [GO:0045727]			positive regulation of cell size [GO:0045793]; positive regulation of translation [GO:0045727]	
Q587J7	reviewed	TDR12_HUMAN	Putative ATP-dependent RNA helicase TDRD12 (EC 3.6.4.13) (ES cell-associated transcript 8 protein) (Tudor domain-containing protein 12)	TDRD12 ECAT8	Homo sapiens (Human)	1177	FUNCTION: Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. {ECO:0000250|UniProtKB:Q9CWU0}.		fertilization [GO:0009566]; germ-line stem cell division [GO:0042078]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	PET complex [GO:1990923]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	PET complex [GO:1990923]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]; fertilization [GO:0009566]; germ-line stem cell division [GO:0042078]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283]	
Q58FF6	reviewed	H90B4_HUMAN	Putative heat shock protein HSP 90-beta 4	HSP90AB4P	Homo sapiens (Human)	505	FUNCTION: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.		cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of macromolecule metabolic process [GO:0060255]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of primary metabolic process [GO:0080090]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082]; cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of macromolecule metabolic process [GO:0060255]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of primary metabolic process [GO:0080090]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q58FF7	reviewed	H90B3_HUMAN	Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc)	HSP90AB3P HSP90BC	Homo sapiens (Human)	597	FUNCTION: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.		cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of macromolecule metabolic process [GO:0060255]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of primary metabolic process [GO:0080090]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082]; cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of macromolecule metabolic process [GO:0060255]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of primary metabolic process [GO:0080090]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q58FF8	reviewed	H90B2_HUMAN	Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb)	HSP90AB2P HSP90BB	Homo sapiens (Human)	381	FUNCTION: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.		cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of macromolecule metabolic process [GO:0060255]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of primary metabolic process [GO:0080090]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082]; cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of macromolecule metabolic process [GO:0060255]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of primary metabolic process [GO:0080090]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q58FG1	reviewed	HS904_HUMAN	Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad)	HSP90AA4P HSP90AD HSPCAL2	Homo sapiens (Human)	418	FUNCTION: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.		cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	cytosol [GO:0005829]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082]	cytosol [GO:0005829]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082]; cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q58G82	reviewed	SY14L_HUMAN	Putative synaptotagmin-14-like protein (Synaptotagmin XIV protein pseudogene 1) (Synaptotagmin XIV-derived protein) (Synaptotagmin XIV-like protein)	SYT14P1 SYT14L SYT14LP1 SYTDEP	Homo sapiens (Human)	188	FUNCTION: Plays a role in melanocyte differentiation; enhances dendrite outgrowth, melanin content and tyrosinase activity through the modulation of ERK and/or CREB pathways (PubMed:23999003). {ECO:0000269|PubMed:16376304, ECO:0000269|PubMed:23999003}.		cell differentiation [GO:0030154]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of dendrite extension [GO:1903861]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]		phospholipid binding [GO:0005543]	phospholipid binding [GO:0005543]; cell differentiation [GO:0030154]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of dendrite extension [GO:1903861]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	
Q5BIV9	reviewed	SPRN_HUMAN	Shadow of prion protein (Protein shadoo)	SPRN SHO	Homo sapiens (Human)	151	FUNCTION: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity). {ECO:0000250}.	MISCELLANEOUS: 'Shadoo' means 'shadow' in Japanese.	protein import into nucleus [GO:0006606]	cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; vesicle [GO:0031982]	nucleic acid binding [GO:0003676]	cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; vesicle [GO:0031982]; nucleic acid binding [GO:0003676]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Q5DT21	reviewed	ISK9_HUMAN	Serine protease inhibitor Kazal-type 9 (Lymphoepithelial Kazal-type-related inhibitor 2)	SPINK9 LEKTI2	Homo sapiens (Human)	86	FUNCTION: Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5. {ECO:0000269|PubMed:19190773, ECO:0000269|PubMed:19194479}.			extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5EBL2	reviewed	ZN628_HUMAN	Zinc finger protein 628	ZNF628	Homo sapiens (Human)	1059	FUNCTION: Transcriptional activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3'. Plays a role in spermiogenesis. {ECO:0000250|UniProtKB:Q8CJ78}.		regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q5FWE3	reviewed	PRRT3_HUMAN	Proline-rich transmembrane protein 3	PRRT3 UNQ5823/PRO19642	Homo sapiens (Human)	981				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5FWF6	reviewed	ZN789_HUMAN	Zinc finger protein 789	ZNF789	Homo sapiens (Human)	425	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5FYB0	reviewed	ARSJ_HUMAN	Arylsulfatase J (ASJ) (EC 3.1.6.-)	ARSJ UNQ372/PRO708	Homo sapiens (Human)	599				actin cytoskeleton [GO:0015629]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]	arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]	actin cytoskeleton [GO:0015629]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5GAN6	reviewed	RNS10_HUMAN	Inactive ribonuclease-like protein 10	RNASE10	Homo sapiens (Human)	216	FUNCTION: Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity). {ECO:0000250}.		defense response to Gram-positive bacterium [GO:0050830]; heterotypic cell-cell adhesion [GO:0034113]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of flagellated sperm motility [GO:1902093]; regulation of fertilization [GO:0080154]; single fertilization [GO:0007338]	extracellular region [GO:0005576]	nucleic acid binding [GO:0003676]	extracellular region [GO:0005576]; nucleic acid binding [GO:0003676]; defense response to Gram-positive bacterium [GO:0050830]; heterotypic cell-cell adhesion [GO:0034113]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of flagellated sperm motility [GO:1902093]; regulation of fertilization [GO:0080154]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q5GH76	reviewed	XKR4_HUMAN	XK-related protein 4 (hXKR4) [Cleaved into: XK-related protein 4, processed form]	XKR4 KIAA1889 XRG4	Homo sapiens (Human)	650	FUNCTION: [XK-related protein 4, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987, PubMed:33725486). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:25231987, PubMed:33725486). {ECO:0000269|PubMed:25231987, ECO:0000269|PubMed:33725486}.		apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5GH67}; Multi-pass membrane protein {ECO:0000255}.
Q5GJ75	reviewed	TP8L3_HUMAN	Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3)	TNFAIP8L3 TIPE3	Homo sapiens (Human)	292	FUNCTION: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling. {ECO:0000250|UniProtKB:Q3TBL6}.		phospholipid metabolic process [GO:0006644]; phospholipid transport [GO:0015914]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of apoptotic process [GO:0042981]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; phospholipid metabolic process [GO:0006644]; phospholipid transport [GO:0015914]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25479791}. Cell membrane {ECO:0000250|UniProtKB:Q3TBL6}. Note=On PDGF activation, translocates from cytoplasm to plasma membrane. {ECO:0000250|UniProtKB:Q3TBL6}.
Q5H9T9	reviewed	FSCB_HUMAN	Fibrous sheath CABYR-binding protein	FSCB C14orf155	Homo sapiens (Human)	825	FUNCTION: May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium. {ECO:0000250|UniProtKB:A1EGX6}.		negative regulation of protein sumoylation [GO:0033234]	sperm fibrous sheath [GO:0035686]; sperm principal piece [GO:0097228]	calcium ion binding [GO:0005509]	sperm fibrous sheath [GO:0035686]; sperm principal piece [GO:0097228]; calcium ion binding [GO:0005509]; negative regulation of protein sumoylation [GO:0033234]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A1EGX6}. Note=Localizes to cortex of the fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella. {ECO:0000250|UniProtKB:A1EGX6}.
Q5H9U9	reviewed	DDX6L_HUMAN	Probable ATP-dependent RNA helicase DDX60-like (EC 3.6.4.13) (DEAD box protein 60-like)	DDX60L	Homo sapiens (Human)	1706			defense response to virus [GO:0051607]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; defense response to virus [GO:0051607]	
Q5HY92	reviewed	FIGN_HUMAN	Fidgetin	FIGN	Homo sapiens (Human)	759	FUNCTION: ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. {ECO:0000269|PubMed:22672901}.		cell cycle [GO:0007049]; cell division [GO:0051301]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; nuclear matrix [GO:0016363]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; nuclear matrix [GO:0016363]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568]; cell cycle [GO:0007049]; cell division [GO:0051301]	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22672901}. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.
Q5HYI7	reviewed	MTX3_HUMAN	Metaxin-3	MTX3	Homo sapiens (Human)	312	FUNCTION: Could function in transport of proteins into the mitochondrion. {ECO:0000250}.		inner mitochondrial membrane organization [GO:0007007]; mitochondrion organization [GO:0007005]; protein transport [GO:0015031]	cytoplasm [GO:0005737]; MIB complex [GO:0140275]; SAM complex [GO:0001401]		cytoplasm [GO:0005737]; MIB complex [GO:0140275]; SAM complex [GO:0001401]; inner mitochondrial membrane organization [GO:0007007]; mitochondrion organization [GO:0007005]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:26477565}. Mitochondrion outer membrane {ECO:0000305}.
Q5HYJ1	reviewed	TECRL_HUMAN	Trans-2,3-enoyl-CoA reductase-like (EC 1.3.1.-) (Steroid 5-alpha-reductase 2-like 2 protein)	TECRL SRD5A2L2	Homo sapiens (Human)	363			very long-chain fatty acid biosynthetic process [GO:0042761]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627]; very long-chain fatty acid biosynthetic process [GO:0042761]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:27861123}.
Q5HYM0	reviewed	ZC12B_HUMAN	Probable ribonuclease ZC3H12B (EC 3.1.-.-) (MCP-induced protein 2) (Zinc finger CCCH domain-containing protein 12B)	ZC3H12B CXorf32 MCPIP2	Homo sapiens (Human)	836	FUNCTION: May function as RNase and regulate the levels of target RNA species. {ECO:0000305}.			cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521]	
Q5J5C9	reviewed	DB121_HUMAN	Beta-defensin 121 (Beta-defensin 21) (DEFB-21) (Defensin, beta 121)	DEFB121 DEFB21	Homo sapiens (Human)	76	FUNCTION: Has antibacterial activity. {ECO:0000305}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5JQC4	reviewed	CT47A_HUMAN	Cancer/testis antigen 47A (Cancer/testis antigen 47) (CT47)	CT47A1 CT47.1; CT47A2 CT47.2; CT47A3 CT47.3; CT47A4 CT47.4; CT47A5 CT47.5; CT47A6 CT47.6; CT47A7 CT47.7; CT47A8 CT47.8; CT47A9 CT47.9; CT47A10 CT47.10; CT47A11 CT47.11; CT47A12 CT47.12	Homo sapiens (Human)	288							
Q5JR12	reviewed	PPM1J_HUMAN	Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C-zeta)	PPM1J PPP2CZ	Homo sapiens (Human)	505				mitochondrion [GO:0005739]	[pyruvate dehydrogenase (lipoamide)] phosphatase activity [GO:0004741]; myosin phosphatase activity [GO:0017018]	mitochondrion [GO:0005739]; [pyruvate dehydrogenase (lipoamide)] phosphatase activity [GO:0004741]; myosin phosphatase activity [GO:0017018]	
Q5JRM2	reviewed	CX066_HUMAN	Uncharacterized protein CXorf66	CXorf66	Homo sapiens (Human)	361				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q5JSZ5	reviewed	PRC2B_HUMAN	Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B)	PRRC2B BAT2L BAT2L1 KIAA0515	Homo sapiens (Human)	2229			cell differentiation [GO:0030154]		RNA binding [GO:0003723]	RNA binding [GO:0003723]; cell differentiation [GO:0030154]	
Q5JT82	reviewed	KLF17_HUMAN	Krueppel-like factor 17 (Zinc finger protein 393)	KLF17 ZNF393	Homo sapiens (Human)	389	FUNCTION: Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity). {ECO:0000250, ECO:0000269|PubMed:16460907}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5JU67	reviewed	CF157_HUMAN	Cilia- and flagella-associated protein 157	CFAP157 C9orf117	Homo sapiens (Human)	520	FUNCTION: Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure. {ECO:0000250|UniProtKB:Q0VFX2}.		sperm axoneme assembly [GO:0007288]	ciliary basal body [GO:0036064]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	microtubule binding [GO:0008017]	ciliary basal body [GO:0036064]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; microtubule binding [GO:0008017]; sperm axoneme assembly [GO:0007288]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q0VFX2}.
Q5JU69	reviewed	TOR2A_HUMAN	Torsin-2A (Torsin family 2 member A) (Torsin-related protein 1)	TOR2A TORP1 UNQ6408/PRO21181	Homo sapiens (Human)	321			chaperone cofactor-dependent protein refolding [GO:0051085]	endoplasmic reticulum lumen [GO:0005788]; nuclear envelope [GO:0005635]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]	endoplasmic reticulum lumen [GO:0005788]; nuclear envelope [GO:0005635]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; chaperone cofactor-dependent protein refolding [GO:0051085]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250}.
Q5JUW0	reviewed	KRBX4_HUMAN	KRAB domain-containing protein 4 (KRAB box domain-containing protein 4)	KRBOX4 ZNF673	Homo sapiens (Human)	171			regulation of DNA-templated transcription [GO:0006355]			regulation of DNA-templated transcription [GO:0006355]	
Q5JUX0	reviewed	SPIN3_HUMAN	Spindlin-3 (Spindlin-like protein 3) (SPIN-3)	SPIN3	Homo sapiens (Human)	258	FUNCTION: Exhibits H3K4me3-binding activity. {ECO:0000269|PubMed:29061846}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	methylated histone binding [GO:0035064]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; methylated histone binding [GO:0035064]; gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355]	
Q5JXA9	reviewed	SIRB2_HUMAN	Signal-regulatory protein beta-2 (SIRP-beta-2) (Protein tyrosine phosphatase non-receptor type substrate 1-like 3) (Protein tyrosine phosphatase non-receptor type substrate protein)	SIRPB2 PTPN1L PTPNS1L3	Homo sapiens (Human)	342				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q5M9Q1	reviewed	NKAPL_HUMAN	NKAP-like protein	NKAPL C6orf194	Homo sapiens (Human)	402	FUNCTION: Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis. {ECO:0000250|UniProtKB:Q5SZT7}.		cell differentiation [GO:0030154]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]	chromatin binding [GO:0003682]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; cell differentiation [GO:0030154]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5SZT7}.
Q5MAI5	reviewed	CDKL4_HUMAN	Cyclin-dependent kinase-like 4 (EC 2.7.11.22)	CDKL4	Homo sapiens (Human)	379			phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q5MJ09	reviewed	SPXN3_HUMAN	Sperm protein associated with the nucleus on the X chromosome N3 (Nuclear-associated protein SPAN-Xn3) (SPANX-N3) (SPANX family member N3)	SPANXN3	Homo sapiens (Human)	141							
Q5MJ68	reviewed	SPDYC_HUMAN	Speedy protein C (Rapid inducer of G2/M progression in oocytes C) (RINGO C) (hSpy/Ringo C)	SPDYC	Homo sapiens (Human)	293	FUNCTION: Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase. {ECO:0000269|PubMed:15611625, ECO:0000269|PubMed:20605920}.		cell cycle [GO:0007049]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; cell cycle [GO:0007049]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20605920}. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase.
Q5QJ74	reviewed	TBCEL_HUMAN	Tubulin-specific chaperone cofactor E-like protein (EL) (Leucine-rich repeat-containing protein 35)	TBCEL LRRC35	Homo sapiens (Human)	424	FUNCTION: Acts as a regulator of tubulin stability. {ECO:0000269|PubMed:15728251}.		microtubule cytoskeleton organization [GO:0000226]; post-chaperonin tubulin folding pathway [GO:0007023]; tubulin complex assembly [GO:0007021]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	alpha-tubulin binding [GO:0043014]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; alpha-tubulin binding [GO:0043014]; microtubule cytoskeleton organization [GO:0000226]; post-chaperonin tubulin folding pathway [GO:0007023]; tubulin complex assembly [GO:0007021]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
Q5R387	reviewed	PA2GC_HUMAN	Putative inactive group IIC secretory phospholipase A2 (Phosphatidylcholine 2-acylhydrolase-like protein GIIC)	PLA2G2C	Homo sapiens (Human)	149	FUNCTION: Inactive phospholipase. {ECO:0000305}.		arachidonic acid secretion [GO:0050482]; fatty acid biosynthetic process [GO:0006633]; lipid catabolic process [GO:0016042]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid metabolic process [GO:0006644]; positive regulation of fibroblast proliferation [GO:0048146]	extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102]; arachidonic acid secretion [GO:0050482]; fatty acid biosynthetic process [GO:0006633]; lipid catabolic process [GO:0016042]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid metabolic process [GO:0006644]; positive regulation of fibroblast proliferation [GO:0048146]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5RHP9	reviewed	ERIC3_HUMAN	Glutamate-rich protein 3	ERICH3 C1orf173	Homo sapiens (Human)	1530			cilium assembly [GO:0060271]	cytoplasm [GO:0005737]; non-motile cilium [GO:0097730]		cytoplasm [GO:0005737]; non-motile cilium [GO:0097730]; cilium assembly [GO:0060271]	
Q5RIA9	reviewed	ZNG1E_HUMAN	Zinc-regulated GTPase metalloprotein activator 1E (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 5) (COBW domain-containing protein 5)	ZNG1E CBWD5	Homo sapiens (Human)	395	FUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1E to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}.		protein maturation [GO:0051604]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; zinc chaperone activity [GO:0140827]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; zinc chaperone activity [GO:0140827]; protein maturation [GO:0051604]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VEH6}.
Q5SRI9	reviewed	MANEA_HUMAN	Glycoprotein endo-alpha-1,2-mannosidase (Endo-alpha mannosidase) (Endomannosidase) (hEndo) (EC 3.2.1.130) (Mandaselin)	MANEA	Homo sapiens (Human)	462				Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	alpha-mannosidase activity [GO:0004559]; glycoprotein endo-alpha-1,2-mannosidase activity [GO:0004569]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; alpha-mannosidase activity [GO:0004559]; glycoprotein endo-alpha-1,2-mannosidase activity [GO:0004569]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15677381, ECO:0000269|PubMed:15760709}; Single-pass type II membrane protein {ECO:0000269|PubMed:15677381, ECO:0000269|PubMed:15760709}.
Q5SRN2	reviewed	TSBP1_HUMAN	Testis-expressed basic protein 1 (Uncharacterized protein C6orf10)	TSBP1 C6orf10	Homo sapiens (Human)	563				membrane [GO:0016020]; nucleus [GO:0005634]		membrane [GO:0016020]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5SXM8	reviewed	DNLZ_HUMAN	DNL-type zinc finger protein (Hsp70-escort protein 1) (HEP1) (mtHsp70-escort protein)	DNLZ C9orf151	Homo sapiens (Human)	178	FUNCTION: May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation. {ECO:0000269|PubMed:23462535}.		protein folding [GO:0006457]; protein import into mitochondrial matrix [GO:0030150]; protein stabilization [GO:0050821]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	protein-folding chaperone binding [GO:0051087]; zinc ion binding [GO:0008270]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; protein-folding chaperone binding [GO:0051087]; zinc ion binding [GO:0008270]; protein folding [GO:0006457]; protein import into mitochondrial matrix [GO:0030150]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23462535}.
Q5SY80	reviewed	CTSRE_HUMAN	Cation channel sperm-associated auxiliary subunit epsilon (CatSper-epsilon) (CatSperepsilon)	CATSPERE C1orf101	Homo sapiens (Human)	951	FUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. {ECO:0000250|UniProtKB:P0DP43}.		flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]	CatSper complex [GO:0036128]; sperm principal piece [GO:0097228]		CatSper complex [GO:0036128]; sperm principal piece [GO:0097228]; flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:28226241}; Single-pass type I membrane protein {ECO:0000255}. Note=Specifically located in the principal piece of sperm tail. {ECO:0000269|PubMed:28226241}.
Q5SZJ8	reviewed	BEND6_HUMAN	BEN domain-containing protein 6	BEND6 C6orf65	Homo sapiens (Human)	279	FUNCTION: Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214). {ECO:0000269|PubMed:23571214}.		negative regulation of Notch signaling pathway [GO:0045746]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714]; negative regulation of Notch signaling pathway [GO:0045746]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6PFX2}.
Q5T013	reviewed	HYI_HUMAN	Putative hydroxypyruvate isomerase (EC 5.3.1.22) (Endothelial cell apoptosis protein E-CE1)	HYI HT036 SB156	Homo sapiens (Human)	277	FUNCTION: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). {ECO:0000250}.		glyoxylate metabolic process [GO:0046487]		hydroxypyruvate isomerase activity [GO:0008903]	hydroxypyruvate isomerase activity [GO:0008903]; glyoxylate metabolic process [GO:0046487]	
Q5T0D9	reviewed	TPRGL_HUMAN	Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A)	TPRG1L FAM79A MOVER	Homo sapiens (Human)	272	FUNCTION: Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release. {ECO:0000250|UniProtKB:A8WCF8}.		calmodulin dependent kinase signaling pathway [GO:0099004]; negative regulation of synaptic transmission [GO:0050805]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic vesicle docking [GO:0016081]	calyx of Held [GO:0044305]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]	calyx of Held [GO:0044305]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; calmodulin dependent kinase signaling pathway [GO:0099004]; negative regulation of synaptic transmission [GO:0050805]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic vesicle docking [GO:0016081]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:A8WCF8}; Peripheral membrane protein {ECO:0000250|UniProtKB:A8WCF8}. Presynaptic active zone {ECO:0000250|UniProtKB:A8WCF8}.
Q5T0L3	reviewed	SPT46_HUMAN	Spermatogenesis-associated protein 46	SPATA46 C1orf111 HSD20	Homo sapiens (Human)	261	FUNCTION: Plays a role in spermiogenesis and fertilization. {ECO:0000250|UniProtKB:Q4FZF2}.		cell differentiation [GO:0030154]; fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; spermatogenesis [GO:0007283]	nuclear membrane [GO:0031965]		nuclear membrane [GO:0031965]; cell differentiation [GO:0030154]; fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q4FZF2}. Note=Located throughout the subacrosomal area. {ECO:0000250|UniProtKB:Q4FZF2}.
Q5T1Q4	reviewed	S35F1_HUMAN	Solute carrier family 35 member F1	SLC35F1 C6orf169	Homo sapiens (Human)	408	FUNCTION: Putative solute transporter. {ECO:0000305}.			synaptic vesicle membrane [GO:0030672]	transmembrane transporter activity [GO:0022857]	synaptic vesicle membrane [GO:0030672]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:34269178}; Multi-pass membrane protein {ECO:0000255}.
Q5T215	reviewed	TPC3L_HUMAN	Trafficking protein particle complex subunit 3-like protein (TRAPPC3-like protein) (BET3-like protein)	TRAPPC3L BET3L	Homo sapiens (Human)	181	FUNCTION: May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000250}.		endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]	cis-Golgi network membrane [GO:0033106]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; TRAPP complex [GO:0030008]		cis-Golgi network membrane [GO:0033106]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; TRAPP complex [GO:0030008]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Q5T2E6	reviewed	ARMD3_HUMAN	Armadillo-like helical domain-containing protein 3	ARMH3 C10orf76	Homo sapiens (Human)	689	FUNCTION: Involved in GBF1 recruitment, Golgi maintenance and protein secretion. {ECO:0000269|PubMed:31519766}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	regulation of Golgi organization [GO:1903358]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]		cytosol [GO:0005829]; Golgi membrane [GO:0000139]; regulation of Golgi organization [GO:1903358]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:31519766}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:31519766}. Note=The majority of ARMD3 is cytosolic, with a portion colocalizing with GBF1 at juxtanuclear Golgi sites. {ECO:0000269|PubMed:31519766}.
Q5T3F8	reviewed	CSCL2_HUMAN	CSC1-like protein 2 (Transmembrane protein 63B)	TMEM63B C6orf110	Homo sapiens (Human)	832	FUNCTION: Acts as an osmosensitive calcium-permeable cation channel (By similarity). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (By similarity). {ECO:0000250|UniProtKB:Q3TWI9}.			actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]	calcium activated cation channel activity [GO:0005227]; mechanosensitive monoatomic ion channel activity [GO:0008381]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]	actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]; calcium activated cation channel activity [GO:0005227]; mechanosensitive monoatomic ion channel activity [GO:0008381]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3TWI9}; Multi-pass membrane protein {ECO:0000255}.
Q5T4T1	reviewed	T170B_HUMAN	Transmembrane protein 170B	TMEM170B	Homo sapiens (Human)	132	FUNCTION: Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets (PubMed:29367600). {ECO:0000269|PubMed:29367600}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]; Wnt signaling pathway [GO:0016055]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29367600}; Multi-pass membrane protein {ECO:0000255}.
Q5T4T6	reviewed	SYC2L_HUMAN	Synaptonemal complex protein 2-like (SCP-2-like) (145 kDa nucleolar protein homolog) (hsNO145)	SYCP2L C6orf177 NO145	Homo sapiens (Human)	812	FUNCTION: Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes. {ECO:0000250|UniProtKB:A0A0M3U1B0}.		meiotic nuclear division [GO:0140013]; negative regulation of programmed cell death [GO:0043069]	condensed chromosome, centromeric region [GO:0000779]; female germ cell nucleus [GO:0001674]; lateral element [GO:0000800]; nucleoplasm [GO:0005654]		condensed chromosome, centromeric region [GO:0000779]; female germ cell nucleus [GO:0001674]; lateral element [GO:0000800]; nucleoplasm [GO:0005654]; meiotic nuclear division [GO:0140013]; negative regulation of programmed cell death [GO:0043069]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17374641}. Chromosome, centromere {ECO:0000269|PubMed:26362258}. Note=Localized to the synaptonemal complex lateral elements in late diplotene oocytes, while it is absent on the synaptonemal complex of leptotene, zygotene, pachytene and early diplotene oocytes (By similarity). Localizes to centromeres in dictyate oocytes (By similarity). Detected in nuclear granules and sizable aggregates (PubMed:17374641). {ECO:0000250|UniProtKB:A0A0M3U1B0, ECO:0000269|PubMed:17374641}.
Q5T5A4	reviewed	CF276_HUMAN	Cilia- and flagella-associated protein 276	CFAP276 C1orf194	Homo sapiens (Human)	169	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis (PubMed:31199454). {ECO:0000250|UniProtKB:E1B9I5, ECO:0000250|UniProtKB:Q9DAD0, ECO:0000269|PubMed:31199454, ECO:0000269|PubMed:36191189}.			axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]		axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31199454}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:31199454}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q5T653	reviewed	RM02_HUMAN	Large ribosomal subunit protein uL2m (39S ribosomal protein L2, mitochondrial) (L2mt) (MRP-L2)	MRPL2 CGI-22	Homo sapiens (Human)	305			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q5T6L9	reviewed	EMARD_HUMAN	Endoplasmic reticulum membrane-associated RNA degradation protein (ER membrane-associated RNA degradation protein)	ERMARD C6orf70	Homo sapiens (Human)	678	FUNCTION: May play a role in neuronal migration during embryonic development. {ECO:0000269|PubMed:24056535}.			endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24056535}; Multi-pass membrane protein {ECO:0000269|PubMed:24056535}.
Q5T6V5	reviewed	QNG1_HUMAN	Queuosine 5'-phosphate N-glycosylase/hydrolase (EC 3.2.2.-) (Q-nucleotide N-glycosylase 1) (Queuine salvage protein QNG1) (Queuosine-nucleotide N-glycosylase/hydrolase)	QNG1 C9orf64	Homo sapiens (Human)	341	FUNCTION: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. In vitro, can also catalyze the release of the q base directly from Q as substrate; however, it was shown that Q is not the biologically relevant substrate. Shows a very low activity on queuosine 3',5'-diphosphate, and cannot release q from queuosine 3'-phosphate and from the 5'-nucleotides AMP, UMP, CMP or GMP, indicating specificity for the queuine base (PubMed:36610787). Can complement the yeast mutant SPAC589.05c, restoring Q incorporation into tRNA (PubMed:24911101). {ECO:0000269|PubMed:24911101, ECO:0000269|PubMed:36610787}.	MISCELLANEOUS: Eukaryotes lack the canonical genes for de novo biosynthesis of queuosine (Q), present in most bacteria. Therefore, this molecule must be sourced from ingested food and/or the gut microbiota, and metabolized to its corresponding nucleobase, queuine (q), before incorporation into cytoplasmic and mitochondrial tRNAs. Incorporation of q into the anticodon of some tRNAs contributes to translational efficiency and accuracy. {ECO:0000305|PubMed:36610787}.	nucleoside salvage [GO:0043174]; tRNA-guanine transglycosylation [GO:0101030]		hydrolase activity [GO:0016787]	hydrolase activity [GO:0016787]; nucleoside salvage [GO:0043174]; tRNA-guanine transglycosylation [GO:0101030]	
Q5T7N2	reviewed	LITD1_HUMAN	LINE-1 type transposase domain-containing protein 1 (ES cell-associated protein 11)	L1TD1 ECAT11	Homo sapiens (Human)	865			retrotransposition [GO:0032197]	intracellular membrane-bounded organelle [GO:0043231]; ribonucleoprotein complex [GO:1990904]	single-stranded RNA binding [GO:0003727]	intracellular membrane-bounded organelle [GO:0043231]; ribonucleoprotein complex [GO:1990904]; single-stranded RNA binding [GO:0003727]; retrotransposition [GO:0032197]	
Q5T871	reviewed	LELP1_HUMAN	Late cornified envelope-like proline-rich protein 1 (Novel small proline-rich protein)	LELP1	Homo sapiens (Human)	98							
Q5T8P6	reviewed	RBM26_HUMAN	RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26)	RBM26 C13orf10 PRO1777	Homo sapiens (Human)	1007			mRNA processing [GO:0006397]	nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]	
Q5TAH2	reviewed	SL9C2_HUMAN	Sodium/hydrogen exchanger 11 (Na(+)/H(+) exchanger 11) (NHE-11) (Solute carrier family 9 member 11) (Solute carrier family 9 member C2)	SLC9C2 SLC9A11	Homo sapiens (Human)	1124	FUNCTION: Involved in pH regulation. {ECO:0000250}.		potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]	plasma membrane [GO:0005886]	potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	plasma membrane [GO:0005886]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q5TBC7	reviewed	B2L15_HUMAN	Bcl-2-like protein 15 (Bcl2-L-15) (Bcl-2 family kin) (Bfk)	BCL2L15 C1orf178	Homo sapiens (Human)	163		MISCELLANEOUS: [Isoform 2]: Pro-apoptotic when overexpressed. {ECO:0000305}.	apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981]	
Q5TC79	reviewed	ZBT37_HUMAN	Zinc finger and BTB domain-containing protein 37	ZBTB37	Homo sapiens (Human)	503	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5TDP6	reviewed	LGSN_HUMAN	Lengsin (Glutamate-ammonia ligase domain-containing protein 1) (Lens glutamine synthase-like)	LGSN GLULD1 LGS	Homo sapiens (Human)	509	FUNCTION: May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity). {ECO:0000250}.		nitrogen compound metabolic process [GO:0006807]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	catalytic activity [GO:0003824]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; catalytic activity [GO:0003824]; nitrogen compound metabolic process [GO:0006807]	
Q5TEC6	reviewed	H37_HUMAN	Histone H3-7	H3-7 H3-2 HIST2H3PS2	Homo sapiens (Human)	136	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000250|UniProtKB:P68431}.			nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
Q5TFQ8	reviewed	SIRBL_HUMAN	Signal-regulatory protein beta-1 isoform 3 (SIRP-beta-1 isoform 3)	SIRPB1	Homo sapiens (Human)	398	FUNCTION: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. {ECO:0000250}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q5TH69	reviewed	BIG3_HUMAN	Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3)	ARFGEF3 BIG3 C6orf92 KIAA1244	Homo sapiens (Human)	2177	FUNCTION: Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}.		regulation of ARF protein signal transduction [GO:0032012]	transport vesicle membrane [GO:0030658]	guanyl-nucleotide exchange factor activity [GO:0005085]	transport vesicle membrane [GO:0030658]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of ARF protein signal transduction [GO:0032012]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19496786}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q3UGY8}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5TH74	reviewed	STPG1_HUMAN	O(6)-methylguanine-induced apoptosis 2 (MAPO2) (Sperm-tail PG-rich repeat-containing protein 1)	STPG1 C1orf201	Homo sapiens (Human)	334	FUNCTION: May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine. {ECO:0000269|PubMed:23028632}.		positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA demethylation [GO:1901537]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]	mitochondrion [GO:0005739]; nucleus [GO:0005634]		mitochondrion [GO:0005739]; nucleus [GO:0005634]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA demethylation [GO:1901537]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q5TID7	reviewed	CC181_HUMAN	Coiled-coil domain-containing protein 181	CCDC181 C1orf114	Homo sapiens (Human)	509	FUNCTION: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. {ECO:0000250|UniProtKB:Q80ZU5}.			cytoplasm [GO:0005737]; manchette [GO:0002177]; microtubule [GO:0005874]; sperm flagellum [GO:0036126]	microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; manchette [GO:0002177]; microtubule [GO:0005874]; sperm flagellum [GO:0036126]; microtubule binding [GO:0008017]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q80ZU5}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q80ZU5}. Note=Localizes to the microtubular manchette of elongating spermatids. Localizes to the sperm flagella and to the basal half of motile cilia. {ECO:0000250|UniProtKB:Q80ZU5}.
Q5TYM5	reviewed	FA72A_HUMAN	Protein FAM72A (Latent membrane protein 1-induced protein) (LMP1-induced protein) (LMPIP)	FAM72A UGENE	Homo sapiens (Human)	149	FUNCTION: May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation. {ECO:0000269|PubMed:21317926}.	MISCELLANEOUS: Highly homologous to GCUD2 but localized to a distinct locus.		cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion. Note=A V5 epitope-tagged construct has been shown to localize to the nucleus (PubMed:18676834). 5-7% of total FAM72A is associated with mitochondria around the nucleus in HEK293 cells (PubMed:21317926). {ECO:0000269|PubMed:18676834, ECO:0000269|PubMed:21317926}.
Q5TYW1	reviewed	ZN658_HUMAN	Zinc finger protein 658	ZNF658	Homo sapiens (Human)	1059	FUNCTION: Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply. {ECO:0000269|PubMed:25582195}.		cellular response to zinc ion [GO:0071294]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]; ribosome biogenesis [GO:0042254]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; cellular response to zinc ion [GO:0071294]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5U5R9	reviewed	HECD2_HUMAN	Probable E3 ubiquitin-protein ligase HECTD2 (EC 2.3.2.26) (HECT domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECTD2)	HECTD2	Homo sapiens (Human)	776	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:28584101}.; FUNCTION: (Microbial infection) Catalyzes ubiquitination of Botulinum neurotoxin A light chain (LC) of C.botulinum neurotoxin type A (BoNT/A). {ECO:0000269|PubMed:28584101}.		protein ubiquitination [GO:0016567]	cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]	
Q5U623	reviewed	MCAF2_HUMAN	Activating transcription factor 7-interacting protein 2 (ATF7-interacting protein 2) (MBD1-containing chromatin-associated factor 2)	ATF7IP2 MCAF2	Homo sapiens (Human)	682	FUNCTION: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable). {ECO:0000305}.		positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	transcription coregulator activity [GO:0003712]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription coregulator activity [GO:0003712]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus.
Q5VT97	reviewed	SYDE2_HUMAN	Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2)	SYDE2	Homo sapiens (Human)	1194	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.		activation of GTPase activity [GO:0090630]; cell migration [GO:0016477]; regulation of Ras protein signal transduction [GO:0046578]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]; synaptic membrane [GO:0097060]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; synaptic membrane [GO:0097060]; GTPase activator activity [GO:0005096]; activation of GTPase activity [GO:0090630]; cell migration [GO:0016477]; regulation of Ras protein signal transduction [GO:0046578]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	
Q5VTE0	reviewed	EF1A3_HUMAN	Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5)	EEF1A1P5 EEF1AL3	Homo sapiens (Human)	462	FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}.		translation [GO:0006412]; translational elongation [GO:0006414]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]; translation [GO:0006412]; translational elongation [GO:0006414]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q5VTH2	reviewed	FLTOP_HUMAN	Protein Flattop (Cilia- and flagella-associated protein 126)	CFAP126 C1orf192 FLTP	Homo sapiens (Human)	177	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (PubMed:36191189). Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear. {ECO:0000250|UniProtKB:Q6P8X9, ECO:0000269|PubMed:36191189}.		cilium organization [GO:0044782]	apical plasma membrane [GO:0016324]; axonemal microtubule [GO:0005879]; ciliary basal body [GO:0036064]; cilium [GO:0005929]		apical plasma membrane [GO:0016324]; axonemal microtubule [GO:0005879]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cilium organization [GO:0044782]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q6P8X9}. Cell projection, cilium {ECO:0000250|UniProtKB:Q6P8X9}. Apical cell membrane {ECO:0000250|UniProtKB:Q6P8X9}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Note=Localizes to the apical cell membrane, the basal body and the primary cilium in monociliated node cells (By similarity). {ECO:0000250|UniProtKB:Q3SZT6, ECO:0000250|UniProtKB:Q6P8X9}.
Q5VTH9	reviewed	DNAI4_HUMAN	Dynein axonemal intermediate chain 4 (WD repeat-containing protein 78)	DNAI4 WDR78	Homo sapiens (Human)	848	FUNCTION: Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility. {ECO:0000250|UniProtKB:E9PYY5}.		axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; hematopoietic progenitor cell differentiation [GO:0002244]	axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein axonemal particle [GO:0120293]; motile cilium [GO:0031514]	dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]	axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein axonemal particle [GO:0120293]; motile cilium [GO:0031514]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; hematopoietic progenitor cell differentiation [GO:0002244]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:E9PYY5}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:E9PYY5}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q6GPB9}.
Q5VTQ0	reviewed	TT39B_HUMAN	Tetratricopeptide repeat protein 39B (TPR repeat protein 39B)	TTC39B C9orf52	Homo sapiens (Human)	682	FUNCTION: Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3). {ECO:0000250|UniProtKB:Q8BYY4}.		cholesterol homeostasis [GO:0042632]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol storage [GO:0010887]; regulation of cholesterol efflux [GO:0010874]; regulation of cholesterol metabolic process [GO:0090181]			cholesterol homeostasis [GO:0042632]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol storage [GO:0010887]; regulation of cholesterol efflux [GO:0010874]; regulation of cholesterol metabolic process [GO:0090181]	
Q5VU97	reviewed	CAHD1_HUMAN	VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1)	CACHD1 KIAA1573 VWCD1	Homo sapiens (Human)	1274	FUNCTION: May regulate voltage-dependent calcium channels. {ECO:0000250}.			voltage-gated calcium channel complex [GO:0005891]	voltage-gated calcium channel activity [GO:0005245]	voltage-gated calcium channel complex [GO:0005891]; voltage-gated calcium channel activity [GO:0005245]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q5VUJ9	reviewed	DRC8_HUMAN	Dynein regulatory complex protein 8 (EF-hand calcium-binding domain-containing protein 2)	EFCAB2 DRC8	Homo sapiens (Human)	269	FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. {ECO:0000250|UniProtKB:A8J3A0}.			cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm principal piece [GO:0097228]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm principal piece [GO:0097228]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8J3A0}.
Q5VUM1	reviewed	SDHF4_HUMAN	Succinate dehydrogenase assembly factor 4, mitochondrial (SDH assembly factor 4) (SDHAF4)	SDHAF4 C6orf57	Homo sapiens (Human)	108	FUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity). {ECO:0000250|UniProtKB:P38345, ECO:0000269|PubMed:24954416}.		cellular respiration [GO:0045333]; innate immune response [GO:0045087]; mitochondrial respiratory chain complex II assembly [GO:0034553]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	enzyme activator activity [GO:0008047]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; enzyme activator activity [GO:0008047]; cellular respiration [GO:0045333]; innate immune response [GO:0045087]; mitochondrial respiratory chain complex II assembly [GO:0034553]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P38345}.
Q5VV17	reviewed	OTUD1_HUMAN	OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7)	OTUD1 DUBA7 OTDC1	Homo sapiens (Human)	481	FUNCTION: Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin (PubMed:23827681). Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:36445135). The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598 (PubMed:36445135). OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation (PubMed:36445135). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:36445135}.		protein K63-linked deubiquitination [GO:0070536]		cysteine-type deubiquitinase activity [GO:0004843]	cysteine-type deubiquitinase activity [GO:0004843]; protein K63-linked deubiquitination [GO:0070536]	
Q5VV52	reviewed	ZN691_HUMAN	Zinc finger protein 691	ZNF691	Homo sapiens (Human)	315	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5VV63	reviewed	ATRN1_HUMAN	Attractin-like protein 1	ATRNL1 KIAA0534	Homo sapiens (Human)	1379	FUNCTION: May play a role in melanocortin signaling pathways that regulate energy homeostasis. {ECO:0000250}.		G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]	carbohydrate binding [GO:0030246]; Notch binding [GO:0005112]	membrane [GO:0016020]; carbohydrate binding [GO:0030246]; Notch binding [GO:0005112]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q5VVH5	reviewed	IKBP1_HUMAN	Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1-binding protein 1)	IRAK1BP1	Homo sapiens (Human)	260	FUNCTION: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity). {ECO:0000250}.		canonical NF-kappaB signal transduction [GO:0007249]; immune response [GO:0006955]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; canonical NF-kappaB signal transduction [GO:0007249]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q5VVW2	reviewed	GARL3_HUMAN	GTPase-activating Rap/Ran-GAP domain-like protein 3	GARNL3	Homo sapiens (Human)	1013			regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; GTPase activator activity [GO:0005096]; regulation of small GTPase mediated signal transduction [GO:0051056]	
Q5VWW1	reviewed	C1QL3_HUMAN	Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13)	C1QL3 CTRP13	Homo sapiens (Human)	255	FUNCTION: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC1 and PCK1 and hence decreases de novo glucose production (By similarity). {ECO:0000250}.		neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; regulation of synapse organization [GO:0050807]	collagen trimer [GO:0005581]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synaptic cleft [GO:0043083]	identical protein binding [GO:0042802]	collagen trimer [GO:0005581]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synaptic cleft [GO:0043083]; identical protein binding [GO:0042802]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; regulation of synapse organization [GO:0050807]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q5VXH4	reviewed	PRAM6_HUMAN	PRAME family member 6	PRAMEF6	Homo sapiens (Human)	476	FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:26138980). The CRL2(PRAMEF6) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). {ECO:0000269|PubMed:26138980}.		negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	
Q5VXJ0	reviewed	LIPK_HUMAN	Lipase member K (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 2)	LIPK LIPL2	Homo sapiens (Human)	399	FUNCTION: Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. {ECO:0000269|PubMed:17562024}.		cornification [GO:0070268]; lipid catabolic process [GO:0016042]	extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]	lipoprotein lipase activity [GO:0004465]	extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lipoprotein lipase activity [GO:0004465]; cornification [GO:0070268]; lipid catabolic process [GO:0016042]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5VXT5	reviewed	SYPL2_HUMAN	Synaptophysin-like protein 2	SYPL2	Homo sapiens (Human)	272	FUNCTION: Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes. {ECO:0000250}.		heart development [GO:0007507]; intracellular calcium ion homeostasis [GO:0006874]; substantia nigra development [GO:0021762]; T-tubule organization [GO:0033292]	synaptic vesicle membrane [GO:0030672]		synaptic vesicle membrane [GO:0030672]; heart development [GO:0007507]; intracellular calcium ion homeostasis [GO:0006874]; substantia nigra development [GO:0021762]; T-tubule organization [GO:0033292]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum. {ECO:0000250}.
Q5VXU1	reviewed	NKAI2_HUMAN	Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2) (Protein FAM77B) (T-cell lymphoma breakpoint-associated target protein 1)	NKAIN2 FAM77B TCBA1	Homo sapiens (Human)	208			regulation of sodium ion transport [GO:0002028]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; regulation of sodium ion transport [GO:0002028]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5VYS4	reviewed	MEDAG_HUMAN	Mesenteric estrogen-dependent adipogenesis protein (Activated in W/Wv mouse stomach 3 homolog) (hAWMS3) (Mesenteric estrogen-dependent adipose 4) (MEDA-4)	MEDAG AWMS3 C13orf33 MEDA4	Homo sapiens (Human)	303	FUNCTION: Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes. {ECO:0000250}.		positive regulation of fat cell differentiation [GO:0045600]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; positive regulation of fat cell differentiation [GO:0045600]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22510272}.
Q5VYY2	reviewed	LIPM_HUMAN	Lipase member M (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 3)	LIPM LIPL3	Homo sapiens (Human)	423	FUNCTION: Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. {ECO:0000269|PubMed:17562024}.		cornification [GO:0070268]; lipid catabolic process [GO:0016042]	extracellular region [GO:0005576]	lipoprotein lipase activity [GO:0004465]	extracellular region [GO:0005576]; lipoprotein lipase activity [GO:0004465]; cornification [GO:0070268]; lipid catabolic process [GO:0016042]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5VZ52	reviewed	MORN5_HUMAN	MORN repeat-containing protein 5	MORN5 C9orf113 C9orf18	Homo sapiens (Human)	161				sperm flagellum [GO:0036126]		sperm flagellum [GO:0036126]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9DAI9}.
Q5VZB9	reviewed	DMRTA_HUMAN	Doublesex- and mab-3-related transcription factor A1	DMRTA1 DMO	Homo sapiens (Human)	504			male mating behavior [GO:0060179]; ovarian follicle development [GO:0001541]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; male mating behavior [GO:0060179]; ovarian follicle development [GO:0001541]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Q5VZP5	reviewed	STYL2_HUMAN	Serine/threonine/tyrosine-interacting-like protein 2 (Inactive dual specificity phosphatase 27)	STYXL2 DUSP27	Homo sapiens (Human)	1158	FUNCTION: May be required for myofiber maturation. {ECO:0000250|UniProtKB:F1QWM2}.		dephosphorylation [GO:0016311]; negative regulation of MAPK cascade [GO:0043409]	cytoplasm [GO:0005737]; sarcomere [GO:0030017]	MAP kinase phosphatase activity [GO:0033549]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; sarcomere [GO:0030017]; MAP kinase phosphatase activity [GO:0033549]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; dephosphorylation [GO:0016311]; negative regulation of MAPK cascade [GO:0043409]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:F1QWM2}.
Q5W0U4	reviewed	BSPRY_HUMAN	B box and SPRY domain-containing protein	BSPRY	Homo sapiens (Human)	402	FUNCTION: May regulate epithelial calcium transport by inhibiting TRPV5 activity. {ECO:0000250}.		calcium ion transport [GO:0006816]; cellular response to leukemia inhibitory factor [GO:1990830]; protein ubiquitination [GO:0016567]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; calcium ion transport [GO:0006816]; cellular response to leukemia inhibitory factor [GO:1990830]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q5XG92	reviewed	EST4A_HUMAN	Carboxylesterase 4A (EC 3.1.1.-)	CES4A CES8 UNQ440/PRO873	Homo sapiens (Human)	561	FUNCTION: Probable carboxylesterase. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: Inactive. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		extracellular region [GO:0005576]	carboxylic ester hydrolase activity [GO:0052689]	extracellular region [GO:0005576]; carboxylic ester hydrolase activity [GO:0052689]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5XX13	reviewed	FBW10_HUMAN	F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor)	FBXW10	Homo sapiens (Human)	1052	FUNCTION: Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1. {ECO:0000269|PubMed:20498703}.			cytosol [GO:0005829]		cytosol [GO:0005829]	
Q63HK3	reviewed	ZKSC2_HUMAN	Zinc finger protein with KRAB and SCAN domains 2 (Zinc finger protein 694)	ZKSCAN2 ZNF694	Homo sapiens (Human)	967	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q63HM1	reviewed	KFA_HUMAN	Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF)	AFMID	Homo sapiens (Human)	303	FUNCTION: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. {ECO:0000255|HAMAP-Rule:MF_03014}.		'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; tryptophan catabolic process to kynurenine [GO:0019441]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	arylformamidase activity [GO:0004061]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; arylformamidase activity [GO:0004061]; 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; tryptophan catabolic process to kynurenine [GO:0019441]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03014}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03014}. Note=Predominantly cytosolic. Some fraction is nuclear. {ECO:0000255|HAMAP-Rule:MF_03014}.
Q641Q3	reviewed	METRL_HUMAN	Meteorin-like protein (Subfatin)	METRNL	Homo sapiens (Human)	311	FUNCTION: Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity). {ECO:0000250}.		brown fat cell differentiation [GO:0050873]; energy homeostasis [GO:0097009]; fat cell differentiation [GO:0045444]; negative regulation of inflammatory response [GO:0050728]; positive regulation of brown fat cell differentiation [GO:0090336]; response to cold [GO:0009409]; response to muscle activity [GO:0014850]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	hormone activity [GO:0005179]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; brown fat cell differentiation [GO:0050873]; energy homeostasis [GO:0097009]; fat cell differentiation [GO:0045444]; negative regulation of inflammatory response [GO:0050728]; positive regulation of brown fat cell differentiation [GO:0090336]; response to cold [GO:0009409]; response to muscle activity [GO:0014850]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q658Y4	reviewed	F91A1_HUMAN	Protein FAM91A1	FAM91A1	Homo sapiens (Human)	838	FUNCTION: As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}.		intracellular protein transport [GO:0006886]; vesicle tethering to Golgi [GO:0099041]	cytoplasmic vesicle [GO:0031410]; trans-Golgi network [GO:0005802]		cytoplasmic vesicle [GO:0031410]; trans-Golgi network [GO:0005802]; intracellular protein transport [GO:0006886]; vesicle tethering to Golgi [GO:0099041]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}. Cytoplasmic vesicle {ECO:0000269|PubMed:29426865}. Note=Recruitment to the TGN requires the presence of GOLGA1, GOLGA4 and TBC1D23. {ECO:0000269|PubMed:29084197}.
Q66K14	reviewed	TBC9B_HUMAN	TBC1 domain family member 9B	TBC1D9B KIAA0676	Homo sapiens (Human)	1250	FUNCTION: May act as a GTPase-activating protein for Rab family protein(s).			membrane [GO:0016020]	calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096]	membrane [GO:0016020]; calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q66K41	reviewed	Z385C_HUMAN	Zinc finger protein 385C	ZNF385C	Homo sapiens (Human)	422				nucleus [GO:0005634]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q66K66	reviewed	TM198_HUMAN	Transmembrane protein 198	TMEM198	Homo sapiens (Human)	360	FUNCTION: Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity. {ECO:0000269|PubMed:21536646}.		positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055]	cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]		cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Largely located to vesicle-like structures. {ECO:0000250}.
Q66LE6	reviewed	2ABD_HUMAN	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta)	PPP2R2D KIAA1541	Homo sapiens (Human)	453	FUNCTION: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). {ECO:0000250}.		cell division [GO:0051301]; exit from mitosis [GO:0010458]; mitotic cell cycle [GO:0000278]	cytosol [GO:0005829]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase regulator activity [GO:0019888]	cytosol [GO:0005829]; protein phosphatase type 2A complex [GO:0000159]; protein phosphatase regulator activity [GO:0019888]; cell division [GO:0051301]; exit from mitosis [GO:0010458]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q68BL7	reviewed	OLM2A_HUMAN	Olfactomedin-like protein 2A (Photomedin-1)	OLFML2A UNQ9394/PRO34319	Homo sapiens (Human)	652			extracellular matrix organization [GO:0030198]; signal transduction [GO:0007165]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	extracellular matrix binding [GO:0050840]; identical protein binding [GO:0042802]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; extracellular matrix binding [GO:0050840]; identical protein binding [GO:0042802]; extracellular matrix organization [GO:0030198]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8BHP7}. Note=Localizes to the podocyte major processes. Colocalized with the major process protein VIM throughout podocyte development. {ECO:0000269|PubMed:22913984}.
Q68BL8	reviewed	OLM2B_HUMAN	Olfactomedin-like protein 2B (Photomedin-2)	OLFML2B	Homo sapiens (Human)	750			extracellular matrix organization [GO:0030198]; signal transduction [GO:0007165]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	extracellular matrix binding [GO:0050840]; identical protein binding [GO:0042802]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; extracellular matrix binding [GO:0050840]; identical protein binding [GO:0042802]; extracellular matrix organization [GO:0030198]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q68CL5	reviewed	TPGS2_HUMAN	Tubulin polyglutamylase complex subunit 2 (PGs2)	TPGS2 C18orf10 HMFN0601 L17	Homo sapiens (Human)	300	FUNCTION: Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. {ECO:0000305|PubMed:34782749}.			cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]		cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:34782749}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:34782749}. Note=Associated with microtubules. {ECO:0000269|PubMed:34782749}.
Q68D51	reviewed	DEN2C_HUMAN	DENN domain-containing protein 2C	DENND2C	Homo sapiens (Human)	928	FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.			nucleoplasm [GO:0005654]	guanyl-nucleotide exchange factor activity [GO:0005085]	nucleoplasm [GO:0005654]; guanyl-nucleotide exchange factor activity [GO:0005085]	
Q68DH5	reviewed	LMBD2_HUMAN	G-protein coupled receptor-associated protein LMBRD2 (LMBR1 domain-containing protein 2)	LMBRD2	Homo sapiens (Human)	695	FUNCTION: Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway (PubMed:28388415). May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable). {ECO:0000269|PubMed:28388415, ECO:0000305|PubMed:28388415}.		adrenergic receptor signaling pathway [GO:0071875]	membrane [GO:0016020]; plasma membrane [GO:0005886]		membrane [GO:0016020]; plasma membrane [GO:0005886]; adrenergic receptor signaling pathway [GO:0071875]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:28388415}; Multi-pass membrane protein {ECO:0000255}.
Q68DY1	reviewed	ZN626_HUMAN	Zinc finger protein 626	ZNF626	Homo sapiens (Human)	528	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q69YN2	reviewed	C19L1_HUMAN	CWF19-like protein 1 (C19L1)	CWF19L1	Homo sapiens (Human)	538			mRNA splicing, via spliceosome [GO:0000398]	post-mRNA release spliceosomal complex [GO:0071014]	RNA lariat debranching enzyme activator activity [GO:0061632]	post-mRNA release spliceosomal complex [GO:0071014]; RNA lariat debranching enzyme activator activity [GO:0061632]; mRNA splicing, via spliceosome [GO:0000398]	
Q69YU5	reviewed	UQCC6_HUMAN	Ubiquinol-cytochrome c reductase complex assembly factor 6 (Protein BRAWNIN)	UQCC6 BR BRAWNIN C12orf73	Homo sapiens (Human)	71	FUNCTION: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263). Mediates early complex III biogenesis (By similarity). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also required for cytochrome c oxidase complex (complex IV) assembly (PubMed:34969438). {ECO:0000250|UniProtKB:Q8BTC1, ECO:0000269|PubMed:32161263, ECO:0000269|PubMed:34969438}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex III assembly [GO:0034551]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex III assembly [GO:0034551]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:32161263, ECO:0000269|PubMed:34969438}; Single-pass type II membrane protein {ECO:0000305|PubMed:32161263}.
Q6A1A2	reviewed	PDPK2_HUMAN	Putative 3-phosphoinositide-dependent protein kinase 2 (EC 2.7.11.1) (3-phosphoinositide-dependent protein kinase 2 pseudogene)	PDPK2P PDPK2	Homo sapiens (Human)	396	FUNCTION: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). {ECO:0000250}.		intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; membrane [GO:0016020]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; membrane [GO:0016020]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q6A555	reviewed	TXND8_HUMAN	Thioredoxin domain-containing protein 8 (Spermatid-specific thioredoxin-3) (Sptrx-3) (Thioredoxin-6)	TXNDC8 SPTRX3 TRX6	Homo sapiens (Human)	127	FUNCTION: May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm.	MISCELLANEOUS: Increased levels, possibly caused by overexpression, are observed in morphologically abnormal spermatozoa from infertile men, suggesting that it may be used as a marker of aberrant spermatogenesis.	cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]		cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15181017}. Golgi apparatus {ECO:0000269|PubMed:15181017}.
Q6AZW8	reviewed	ZN660_HUMAN	Zinc finger protein 660	ZNF660	Homo sapiens (Human)	331	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6B0K9	reviewed	HBM_HUMAN	Hemoglobin subunit mu (Hemoglobin mu chain) (Mu-globin)	HBM HBAP2	Homo sapiens (Human)	141			cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]	haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]	heme binding [GO:0020037]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]	haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]	
Q6DHY5	reviewed	TBC3G_HUMAN	TBC1 domain family member 3G	TBC1D3G	Homo sapiens (Human)	549	FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250}.	MISCELLANEOUS: TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor. {ECO:0000305}.		plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associated with lipid rafts. {ECO:0000250}.
Q6DWJ6	reviewed	GP139_HUMAN	Probable G-protein coupled receptor 139 (G(q)-coupled orphan receptor GPRg1) (G-protein-coupled receptor PGR3)	GPR139 GPRG1 PGR3	Homo sapiens (Human)	353	FUNCTION: Orphan receptor. Seems to act through a G(q/11)-mediated pathway.		G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; neuropeptide receptor activity [GO:0008188]	plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; neuropeptide receptor activity [GO:0008188]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6GPH6	reviewed	IPIL1_HUMAN	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1	ITPRIPL1 KIAA1754L	Homo sapiens (Human)	555				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6H9L7	reviewed	ISM2_HUMAN	Isthmin-2 (Thrombospondin and AMOP domain-containing isthmin-like protein 1) (Thrombospondin type-1 domain-containing protein 3)	ISM2 TAIL1 THSD3 PSEC0137	Homo sapiens (Human)	571				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6IEE7	reviewed	T132E_HUMAN	Transmembrane protein 132E	TMEM132E	Homo sapiens (Human)	1074	FUNCTION: Required for normal inner ear hair cell function and hearing. {ECO:0000269|PubMed:25331638}.		posterior lateral line neuromast hair cell development [GO:0035677]	cell body [GO:0044297]; membrane [GO:0016020]		cell body [GO:0044297]; membrane [GO:0016020]; posterior lateral line neuromast hair cell development [GO:0035677]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6IFH4	reviewed	OR6B2_HUMAN	Olfactory receptor 6B2 (Olfactory receptor OR2-1)	OR6B2 OR6B2P	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			cytosol [GO:0005829]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6IMI4	reviewed	ST6B1_HUMAN	Sulfotransferase 6B1 (ST6B1) (Thyroxine sulfotransferase) (EC 2.8.2.n2)	SULT6B1	Homo sapiens (Human)	303	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity). {ECO:0000250|UniProtKB:P0CC03}.		sulfation [GO:0051923]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; sulfotransferase activity [GO:0008146]; sulfation [GO:0051923]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P0CC03}.
Q6IPR1	reviewed	ETFR1_HUMAN	Electron transfer flavoprotein regulatory factor 1 (LYR motif-containing protein 5)	ETFRF1 LYRM5	Homo sapiens (Human)	90	FUNCTION: Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). {ECO:0000269|PubMed:27499296}.		respiratory electron transport chain [GO:0022904]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; respiratory electron transport chain [GO:0022904]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:27499296}.
Q6IPR3	reviewed	TYW3_HUMAN	tRNA wybutosine-synthesizing protein 3 homolog (tRNA-yW-synthesizing protein 3) (EC 2.1.1.282) (tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase)	TYW3 C1orf171	Homo sapiens (Human)	259	FUNCTION: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). {ECO:0000250}.		tRNA methylation [GO:0030488]; wybutosine biosynthetic process [GO:0031591]	cytoplasm [GO:0005737]	tRNA methyltransferase activity [GO:0008175]	cytoplasm [GO:0005737]; tRNA methyltransferase activity [GO:0008175]; tRNA methylation [GO:0030488]; wybutosine biosynthetic process [GO:0031591]	
Q6IPT4	reviewed	NB5R5_HUMAN	NADH-cytochrome b5 reductase-like (EC 1.6.2.2)	CYB5RL	Homo sapiens (Human)	315	FUNCTION: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}.		bicarbonate transport [GO:0015701]	endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]	cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]	endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; bicarbonate transport [GO:0015701]	
Q6IQ32	reviewed	ADNP2_HUMAN	Activity-dependent neuroprotector homeobox protein 2 (ADNP homeobox protein 2) (Zinc finger protein 508)	ADNP2 KIAA0863 ZNF508	Homo sapiens (Human)	1131	FUNCTION: May be involved in transcriptional regulation. May play a role in neuronal function; perhaps involved in protection of brain tissues from oxidative stress. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q8CHC8}.		nervous system development [GO:0007399]; regulation of gene expression [GO:0010468]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; nervous system development [GO:0007399]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ISS4	reviewed	LAIR2_HUMAN	Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) (CD antigen CD306)	LAIR2 CD306	Homo sapiens (Human)	152				extracellular region [GO:0005576]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Secreted.
Q6IV72	reviewed	ZN425_HUMAN	Zinc finger protein 425	ZNF425	Homo sapiens (Human)	752	FUNCTION: Acts as a transcriptional repressor. {ECO:0000269|PubMed:21266108}.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21266108}. Cytoplasm {ECO:0000269|PubMed:21266108}. Note=Predominantly expressed in the nucleus.
Q6JEL2	reviewed	KLH10_HUMAN	Kelch-like protein 10	KLHL10	Homo sapiens (Human)	608	FUNCTION: May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.		cell morphogenesis [GO:0000902]; fertilization [GO:0009566]; homeostasis of number of cells within a tissue [GO:0048873]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; protein ubiquitination [GO:0016567]; spermatid development [GO:0007286]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; cell morphogenesis [GO:0000902]; fertilization [GO:0009566]; homeostasis of number of cells within a tissue [GO:0048873]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; protein ubiquitination [GO:0016567]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q6MZT1	reviewed	R7BP_HUMAN	Regulator of G-protein signaling 7-binding protein (R7 family-binding protein)	RGS7BP R7BP	Homo sapiens (Human)	257	FUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. {ECO:0000250|UniProtKB:Q8BQP9}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of postsynaptic membrane potential [GO:0060078]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine head [GO:0044327]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]		axon [GO:0030424]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine head [GO:0044327]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of postsynaptic membrane potential [GO:0060078]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BQP9}. Cytoplasm {ECO:0000250|UniProtKB:Q8BQP9}. Cell membrane {ECO:0000250|UniProtKB:Q8BQP9}; Lipid-anchor {ECO:0000250|UniProtKB:Q8BQP9}. Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation. {ECO:0000250|UniProtKB:Q8BQP9}.
Q6MZW2	reviewed	FSTL4_HUMAN	Follistatin-related protein 4 (Follistatin-like protein 4)	FSTL4 KIAA1061	Homo sapiens (Human)	842			cell differentiation [GO:0030154]; negative regulation of brain-derived neurotrophic factor receptor signaling pathway [GO:0031549]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendritic spine development [GO:0061000]; regulation of BMP signaling pathway [GO:0030510]	extracellular region [GO:0005576]; secretory granule [GO:0030141]	brain-derived neurotrophic factor binding [GO:0048403]; calcium ion binding [GO:0005509]	extracellular region [GO:0005576]; secretory granule [GO:0030141]; brain-derived neurotrophic factor binding [GO:0048403]; calcium ion binding [GO:0005509]; cell differentiation [GO:0030154]; negative regulation of brain-derived neurotrophic factor receptor signaling pathway [GO:0031549]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendritic spine development [GO:0061000]; regulation of BMP signaling pathway [GO:0030510]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6N063	reviewed	OGFD2_HUMAN	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (EC 1.14.11.-)	OGFOD2	Homo sapiens (Human)	350					dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	
Q6NSX1	reviewed	CCD70_HUMAN	Coiled-coil domain-containing protein 70	CCDC70	Homo sapiens (Human)	233				mitochondrion [GO:0005739]; plasma membrane [GO:0005886]		mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255}.
Q6NSZ9	reviewed	ZSC25_HUMAN	Zinc finger and SCAN domain-containing protein 25 (Zinc finger protein 498)	ZSCAN25 ZNF498	Homo sapiens (Human)	544	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q6NT32	reviewed	EST5A_HUMAN	Carboxylesterase 5A (EC 3.1.1.1) (Carboxylesterase-like urinary excreted protein homolog) (Cauxin)	CES5A CES7	Homo sapiens (Human)	575	FUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. {ECO:0000250}.			extracellular region [GO:0005576]	carboxylesterase activity [GO:0106435]	extracellular region [GO:0005576]; carboxylesterase activity [GO:0106435]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q6NUJ1	reviewed	SAPL1_HUMAN	Proactivator polypeptide-like 1 [Cleaved into: Saposin A-like; Saposin B-Val-like; Saposin B-like; Saposin C-like; Saposin D-like]	PSAPL1	Homo sapiens (Human)	521	FUNCTION: May activate the lysosomal degradation of sphingolipids. {ECO:0000250}.		adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; prostate gland growth [GO:0060736]; regulation of lipid metabolic process [GO:0019216]; sphingolipid metabolic process [GO:0006665]	cytosol [GO:0005829]; extracellular region [GO:0005576]; lysosome [GO:0005764]		cytosol [GO:0005829]; extracellular region [GO:0005576]; lysosome [GO:0005764]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; prostate gland growth [GO:0060736]; regulation of lipid metabolic process [GO:0019216]; sphingolipid metabolic process [GO:0006665]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6NUK4	reviewed	REEP3_HUMAN	Receptor expression-enhancing protein 3	REEP3 C10orf74	Homo sapiens (Human)	255	FUNCTION: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes. {ECO:0000269|PubMed:23911198}.		cell division [GO:0051301]; endoplasmic reticulum tubular network organization [GO:0071786]; mitotic nuclear membrane reassembly [GO:0007084]; nuclear envelope organization [GO:0006998]	cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]	microtubule binding [GO:0008017]	cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; microtubule binding [GO:0008017]; cell division [GO:0051301]; endoplasmic reticulum tubular network organization [GO:0071786]; mitotic nuclear membrane reassembly [GO:0007084]; nuclear envelope organization [GO:0006998]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q6NUM6	reviewed	TYW1B_HUMAN	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 2) (tRNA wybutosine-synthesizing protein 1 homolog B)	TYW1B RSAFD2	Homo sapiens (Human)	668	FUNCTION: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). {ECO:0000250}.		wybutosine biosynthetic process [GO:0031591]		4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; tRNA-4-demethylwyosine synthase activity [GO:0102521]	4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; tRNA-4-demethylwyosine synthase activity [GO:0102521]; wybutosine biosynthetic process [GO:0031591]	
Q6NUM9	reviewed	RETST_HUMAN	All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein)	RETSAT PPSIG UNQ439/PRO872	Homo sapiens (Human)	610	FUNCTION: Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. {ECO:0000250|UniProtKB:Q64FW2}.		retinol metabolic process [GO:0042572]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]	all-trans-retinol 13,14-reductase activity [GO:0051786]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; all-trans-retinol 13,14-reductase activity [GO:0051786]; retinol metabolic process [GO:0042572]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64FW2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64FW2}.
Q6NUS8	reviewed	UD3A1_HUMAN	UDP-glucuronosyltransferase 3A1 (UDPGT 3A1) (EC 2.4.1.17)	UGT3A1	Homo sapiens (Human)	523	FUNCTION: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). {ECO:0000250}.			UDP-N-acetylglucosamine transferase complex [GO:0043541]	glucuronosyltransferase activity [GO:0015020]; UDP-glycosyltransferase activity [GO:0008194]	UDP-N-acetylglucosamine transferase complex [GO:0043541]; glucuronosyltransferase activity [GO:0015020]; UDP-glycosyltransferase activity [GO:0008194]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6NVV7	reviewed	CDPF1_HUMAN	Cysteine-rich DPF motif domain-containing protein 1	CDPF1 C22orf40	Homo sapiens (Human)	123							
Q6NW34	reviewed	NEPRO_HUMAN	Nucleolus and neural progenitor protein	NEPRO C3orf17	Homo sapiens (Human)	567	FUNCTION: May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development. {ECO:0000250|UniProtKB:Q8R2U2}.		negative regulation of neuron differentiation [GO:0045665]; positive regulation of Notch signaling pathway [GO:0045747]	nucleolus [GO:0005730]; nucleus [GO:0005634]		nucleolus [GO:0005730]; nucleus [GO:0005634]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of Notch signaling pathway [GO:0045747]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8R2U2}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8R2U2}.
Q6NXE6	reviewed	ARMC6_HUMAN	Armadillo repeat-containing protein 6	ARMC6	Homo sapiens (Human)	501			hematopoietic progenitor cell differentiation [GO:0002244]	cytosol [GO:0005829]		cytosol [GO:0005829]; hematopoietic progenitor cell differentiation [GO:0002244]	
Q6NXR0	reviewed	IIGP5_HUMAN	Interferon-inducible GTPase 5 (EC 3.6.5.-) (Immunity-related GTPase cinema 1)	IRGC IIGP5 IRGC1	Homo sapiens (Human)	463			defense response to other organism [GO:0098542]	membrane [GO:0016020]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	membrane [GO:0016020]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; defense response to other organism [GO:0098542]	
Q6NXR4	reviewed	TTI2_HUMAN	TELO2-interacting protein 2	TTI2 C8orf41	Homo sapiens (Human)	508	FUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. {ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650}.		positive regulation of DNA damage checkpoint [GO:2000003]; protein stabilization [GO:0050821]	nucleus [GO:0005634]; TTT complex [GO:0110078]		nucleus [GO:0005634]; TTT complex [GO:0110078]; positive regulation of DNA damage checkpoint [GO:2000003]; protein stabilization [GO:0050821]	
Q6NY19	reviewed	KANK3_HUMAN	KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47)	KANK3 ANKRD47	Homo sapiens (Human)	821	FUNCTION: May be involved in the control of cytoskeleton formation by regulating actin polymerization.		negative regulation of actin filament polymerization [GO:0030837]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; negative regulation of actin filament polymerization [GO:0030837]	
Q6NZ67	reviewed	MZT2B_HUMAN	Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B)	MZT2B FAM128B MOZART2B	Homo sapiens (Human)	158				centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin ring complex [GO:0000931]; nucleoplasm [GO:0005654]; spindle [GO:0005819]		centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin ring complex [GO:0000931]; nucleoplasm [GO:0005654]; spindle [GO:0005819]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20360068}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20360068}.
Q6P1K8	reviewed	T2H2L_HUMAN	General transcription factor IIH subunit 2-like protein (General transcription factor IIH polypeptide 2-like protein)	GTF2H2C; GTF2H2C_2 GTF2H2D	Homo sapiens (Human)	395	FUNCTION: Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. {ECO:0000250}.		DNA-templated transcription [GO:0006351]; nucleotide-excision repair [GO:0006289]; regulation of transcription by RNA polymerase II [GO:0006357]	nuclear speck [GO:0016607]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]	zinc ion binding [GO:0008270]	nuclear speck [GO:0016607]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; zinc ion binding [GO:0008270]; DNA-templated transcription [GO:0006351]; nucleotide-excision repair [GO:0006289]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q6P1L8	reviewed	RM14_HUMAN	Large ribosomal subunit protein uL14m (39S ribosomal protein L14, mitochondrial) (L14mt) (MRP-L14) (39S ribosomal protein L32, mitochondrial) (L32mt) (MRP-L32)	MRPL14 MRPL32 RPML32	Homo sapiens (Human)	145	FUNCTION: Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable). {ECO:0000305|PubMed:22829778}.		mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11543634, ECO:0000269|PubMed:22829778, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q6P1R4	reviewed	DUS1L_HUMAN	tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC 1.3.1.88) (tRNA-dihydrouridine synthase 1-like)	DUS1L	Homo sapiens (Human)	473	FUNCTION: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. {ECO:0000269|PubMed:34798057}.		tRNA dihydrouridine synthesis [GO:0002943]		flavin adenine dinucleotide binding [GO:0050660]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine16 synthase activity [GO:0102262]; tRNA-dihydrouridine17 synthase activity [GO:0102263]	flavin adenine dinucleotide binding [GO:0050660]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine16 synthase activity [GO:0102262]; tRNA-dihydrouridine17 synthase activity [GO:0102263]; tRNA dihydrouridine synthesis [GO:0002943]	
Q6P1S2	reviewed	CC033_HUMAN	Protein C3orf33 (Protein AC3-33)	C3orf33 MSTP052	Homo sapiens (Human)	294	FUNCTION: [Isoform 2]: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane.		negative regulation of ERK1 and ERK2 cascade [GO:0070373]; regulation of DNA-binding transcription factor activity [GO:0051090]	extracellular space [GO:0005615]; membrane [GO:0016020]		extracellular space [GO:0005615]; membrane [GO:0016020]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; regulation of DNA-binding transcription factor activity [GO:0051090]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:20680465}.
Q6P3S6	reviewed	FBX42_HUMAN	F-box only protein 42 (Just one F-box and Kelch domain-containing protein)	FBXO42 FBX42 JFK KIAA1332	Homo sapiens (Human)	717	FUNCTION: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}.			SCF ubiquitin ligase complex [GO:0019005]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase-substrate adaptor activity [GO:1990756]	
Q6P444	reviewed	MTFR2_HUMAN	Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1)	MTFR2 DUFD1 FAM54A	Homo sapiens (Human)	385	FUNCTION: May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Note=Associated with membranes. {ECO:0000250}.
Q6P499	reviewed	NPAL3_HUMAN	NIPA-like protein 3	NIPAL3 NPAL3	Homo sapiens (Human)	406			magnesium ion transport [GO:0015693]	membrane [GO:0016020]	magnesium ion transmembrane transporter activity [GO:0015095]	membrane [GO:0016020]; magnesium ion transmembrane transporter activity [GO:0015095]; magnesium ion transport [GO:0015693]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6P4D5	reviewed	PBIR3_HUMAN	PABIR family member 1	PABIR3 FAM122C	Homo sapiens (Human)	195					protein serine/threonine phosphatase inhibitor activity [GO:0004865]	protein serine/threonine phosphatase inhibitor activity [GO:0004865]	
Q6P4E1	reviewed	GOLM2_HUMAN	Protein GOLM2 (Cancer susceptibility candidate gene 4 protein) (CASC4) (Golgi membrane protein 2)	GOLM2 CASC4 UNQ2573/PRO6308	Homo sapiens (Human)	436				Golgi apparatus [GO:0005794]; membrane [GO:0016020]		Golgi apparatus [GO:0005794]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q6P4F7	reviewed	RHGBA_HUMAN	Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A)	ARHGAP11A KIAA0013	Homo sapiens (Human)	1023	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}.		positive regulation of GTPase activity [GO:0043547]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]; nucleus [GO:0005634]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; nucleus [GO:0005634]; GTPase activator activity [GO:0005096]; positive regulation of GTPase activity [GO:0043547]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31883789}.
Q6P582	reviewed	MZT2A_HUMAN	Mitotic-spindle organizing protein 2A (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A)	MZT2A FAM128A MOZART2A	Homo sapiens (Human)	158				centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin ring complex [GO:0000931]; nucleoplasm [GO:0005654]; spindle [GO:0005819]		centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin ring complex [GO:0000931]; nucleoplasm [GO:0005654]; spindle [GO:0005819]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
Q6P5S2	reviewed	LEG1H_HUMAN	Protein LEG1 homolog	LEG1 C6orf58	Homo sapiens (Human)	330	FUNCTION: May be involved in early liver development. {ECO:0000250|UniProtKB:A5PF61, ECO:0000250|UniProtKB:Q4QRF7}.			extracellular exosome [GO:0070062]; extracellular space [GO:0005615]		extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A5PF61, ECO:0000250|UniProtKB:Q4QRF7}.
Q6P656	reviewed	CF161_HUMAN	Cilia- and flagella-associated protein 161	CFAP161 C15orf26	Homo sapiens (Human)	301	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.		cilium assembly [GO:0060271]	axonemal microtubule [GO:0005879]; motile cilium [GO:0031514]		axonemal microtubule [GO:0005879]; motile cilium [GO:0031514]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q6P996	reviewed	PDXD1_HUMAN	Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-)	PDXDC1 KIAA0251	Homo sapiens (Human)	788			carboxylic acid metabolic process [GO:0019752]	Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]	cadherin binding [GO:0045296]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170]	Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; cadherin binding [GO:0045296]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170]; carboxylic acid metabolic process [GO:0019752]	
Q6P9G4	reviewed	TM154_HUMAN	Transmembrane protein 154	TMEM154	Homo sapiens (Human)	183				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6P9H5	reviewed	GIMA6_HUMAN	GTPase IMAP family member 6 (Immunity-associated nucleotide 2 protein) (IAN-2) (hIAN2) (Immunity-associated nucleotide 6 protein) (IAN-6) (hIAN6)	GIMAP6 IAN2 IAN6	Homo sapiens (Human)	292				cytosol [GO:0005829]	GTP binding [GO:0005525]	cytosol [GO:0005829]; GTP binding [GO:0005525]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23454188}.
Q6PB30	reviewed	CSAG1_HUMAN	Chondrosarcoma-associated gene 1 protein (Cancer/testis antigen 24.1) (CT24.1) (Cancer/testis antigen CSAGE)	CSAG1 CSAGE	Homo sapiens (Human)	78	FUNCTION: May play an important role in maintaining centrosome integrity during mitosis. {ECO:0000269|PubMed:32295846}.		centrosome cycle [GO:0007098]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle pole [GO:0000922]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle pole [GO:0000922]; centrosome cycle [GO:0007098]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:32295846}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:32295846}. Note=Localizes at spindle poles and/or centrosomes in both mitotic and interphase cells (PubMed:32295846). Spindle pole localization is more pronounced during mitosis (PubMed:32295846). Centrosomal localization culminates at prophase (PubMed:32295846). {ECO:0000269|PubMed:32295846}.
Q6PCB8	reviewed	EMB_HUMAN	Embigin	EMB	Homo sapiens (Human)	327	FUNCTION: Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane (By similarity). {ECO:0000250|UniProtKB:O88775}.		axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; plasma membrane lactate transport [GO:0035879]	axon [GO:0030424]; plasma membrane [GO:0005886]; synapse [GO:0045202]	cell-cell adhesion mediator activity [GO:0098632]	axon [GO:0030424]; plasma membrane [GO:0005886]; synapse [GO:0045202]; cell-cell adhesion mediator activity [GO:0098632]; axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; plasma membrane lactate transport [GO:0035879]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O88775}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O88775}. Synapse {ECO:0000250|UniProtKB:P21995}. Note=Localizes to the neuromuscular junctions. {ECO:0000250|UniProtKB:P21995}.
Q6PDA7	reviewed	SG11A_HUMAN	Sperm-associated antigen 11A (Antimicrobial-like protein Bin-1b) (Human epididymis-specific protein 2) (He2) (Protein EP2) (Sperm antigen HE2)	SPAG11A BIN1B EP2 HE2	Homo sapiens (Human)	123	FUNCTION: Has antimicrobial activity against E.coli (By similarity). Plays a role in the defense response in the male reproductive tract, contributing to sperm maturation, storage and protection (By similarity). {ECO:0000250|UniProtKB:Q8VBV2}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to bacterium [GO:0042742]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to bacterium [GO:0042742]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6PEY0	reviewed	CXB7_HUMAN	Gap junction beta-7 protein (Connexin-25) (Cx25)	GJB7 CX25	Homo sapiens (Human)	223	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. {ECO:0000250, ECO:0000269|PubMed:12064583}.		cell-cell signaling [GO:0007267]; transmembrane transport [GO:0055085]	connexin complex [GO:0005922]	gap junction channel activity [GO:0005243]	connexin complex [GO:0005922]; gap junction channel activity [GO:0005243]; cell-cell signaling [GO:0007267]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
Q6PF04	reviewed	ZN613_HUMAN	Zinc finger protein 613	ZNF613	Homo sapiens (Human)	617	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6PI73	reviewed	LIRA6_HUMAN	Leukocyte immunoglobulin-like receptor subfamily A member 6 (Immunoglobulin-like transcript 8) (ILT-8) (Leukocyte Ig-like receptor)	LILRA6 ILT8	Homo sapiens (Human)	481	FUNCTION: May act as receptor for class I MHC antigens. {ECO:0000250}.	MISCELLANEOUS: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	adaptive immune response [GO:0002250]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6PII3	reviewed	CC174_HUMAN	Coiled-coil domain-containing protein 174	CCDC174 C3orf19	Homo sapiens (Human)	467	FUNCTION: Probably involved in neuronal development. {ECO:0000269|PubMed:26358778}.			nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26358778}. Note=In the nucleus of neuroblastoma cells, it colocalizes with EIF4A3, a component of exon junction complex. {ECO:0000269|PubMed:26358778}.
Q6PIS1	reviewed	S23A3_HUMAN	Solute carrier family 23 member 3 (HPC E2-binding protein 3) (Na(+)/L-ascorbic acid transporter 3) (Sodium-dependent vitamin C transporter 3)	SLC23A3 E2BP3 SVCT3	Homo sapiens (Human)	610	FUNCTION: Acts as a sodium-dependent hypoxanthine transporter (PubMed:35094660). May show xanthine-hypoxanthine exchange activity (PubMed:35094660). {ECO:0000269|PubMed:35094660}.		hypoxanthine transport [GO:0035344]	plasma membrane region [GO:0098590]	L-ascorbic acid transmembrane transporter activity [GO:0015229]	plasma membrane region [GO:0098590]; L-ascorbic acid transmembrane transporter activity [GO:0015229]; hypoxanthine transport [GO:0035344]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q6PJ21	reviewed	SPSB3_HUMAN	SPRY domain-containing SOCS box protein 3 (SSB-3)	SPSB3 C16orf31 SSB3	Homo sapiens (Human)	355	FUNCTION: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]		cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	
Q6PJG2	reviewed	MDEAS_HUMAN	Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1)	MIDEAS C14orf117 C14orf43 ELMSAN1	Homo sapiens (Human)	1045			negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714]	histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]; DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.
Q6PJQ5	reviewed	FOXR2_HUMAN	Forkhead box protein R2 (Forkhead box protein N6)	FOXR2 FOXN6	Homo sapiens (Human)	311				chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Q6PK18	reviewed	OGFD3_HUMAN	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (EC 1.14.11.-)	OGFOD3 C17orf101	Homo sapiens (Human)	319				membrane [GO:0016020]	dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	membrane [GO:0016020]; dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q6PKH6	reviewed	DR4L2_HUMAN	Dehydrogenase/reductase SDR family member 4-like 2 (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 25C member 3) (Protein SDR25C3)	DHRS4L2 SDR25C3	Homo sapiens (Human)	232	FUNCTION: Probable oxidoreductase. {ECO:0000250}.	MISCELLANEOUS: Three homologous proteins DHRS4, DHRS4L1, and DHRS4L2 are derived from gene duplication of DHRS4, and the gene cluster is arranged in tandem in chromosome 14. {ECO:0000269|PubMed:27323117}.	retinal metabolic process [GO:0042574]	extracellular region [GO:0005576]; peroxisome [GO:0005777]	carbonyl reductase (NADPH) activity [GO:0004090]	extracellular region [GO:0005576]; peroxisome [GO:0005777]; carbonyl reductase (NADPH) activity [GO:0004090]; retinal metabolic process [GO:0042574]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6Q8B3	reviewed	MO2R2_HUMAN	Cell surface glycoprotein CD200 receptor 2 (CD200 cell surface glycoprotein receptor-like 2) (CD200 receptor-like 2) (HuCD200R2) (CD200 cell surface glycoprotein receptor-like a) (CD200RLa) (Cell surface glycoprotein CD200 receptor 1-like) (Cell surface glycoprotein OX2 receptor 2)	CD200R1L CD200R2	Homo sapiens (Human)	271	FUNCTION: May be a receptor for the CD200/OX2 cell surface glycoprotein. {ECO:0000250}.		regulation of neuroinflammatory response [GO:0150077]	external side of plasma membrane [GO:0009897]	signaling receptor activity [GO:0038023]	external side of plasma membrane [GO:0009897]; signaling receptor activity [GO:0038023]; regulation of neuroinflammatory response [GO:0150077]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6QEF8	reviewed	CORO6_HUMAN	Coronin-6 (Coronin-like protein E) (Clipin-E)	CORO6 PP1009 PP1782 PP1881	Homo sapiens (Human)	472			actin filament organization [GO:0007015]; cell migration [GO:0016477]		actin filament binding [GO:0051015]	actin filament binding [GO:0051015]; actin filament organization [GO:0007015]; cell migration [GO:0016477]	
Q6R2W3	reviewed	SCND3_HUMAN	SCAN domain-containing protein 3 (Transposon-derived Buster4 transposase-like protein) (Zinc finger BED domain-containing protein 9)	SCAND3 Buster4 KIAA1925 ZBED9 ZNF305P2 ZNF452	Homo sapiens (Human)	1325		MISCELLANEOUS: Highly expressed in non-small-cell lung carcinoma (NSCLC) tissue, with increased expression correlating with advanced disease, lymph node metastases and poor prognosis, as such may be a candidate prognostic marker (PubMed:28418919). May act as an oncogene and promote tumor growth via positive regulation of cell cycle progression at G1/S phase transition (PubMed:28418919). May promote invasion and metastasis via activation of the AKT/GSK-3 beta signaling pathway (PubMed:28418919). Expressed in the cytoplasm in NSCLC tissue (PubMed:28418919). {ECO:0000269|PubMed:28418919}.; MISCELLANEOUS: May be derived from an ancient transposon that has lost its ability to translocate. {ECO:0000305|PubMed:23533661}.	DNA integration [GO:0015074]; positive regulation of cell cycle [GO:0045787]; positive regulation of epithelial cell proliferation [GO:0050679]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; DNA integration [GO:0015074]; positive regulation of cell cycle [GO:0045787]; positive regulation of epithelial cell proliferation [GO:0050679]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q6RSH7	reviewed	VHLL_HUMAN	von Hippel-Lindau-like protein (VHL-like protein) (VLP)	VHLL VLP	Homo sapiens (Human)	139	FUNCTION: Functions as a dominant-negative VHL to serve as a protector of HIFalpha. {ECO:0000269|PubMed:14757845}.	MISCELLANEOUS: Has little or no E3 ubiquitin ligase activity as it lacks the alpha domain required for nucleating the multiprotein E3 ubiquitin ligase complex.					
Q6SJ96	reviewed	TBPL2_HUMAN	TATA box-binding protein-like 2 (TBP-like 2) (TATA box-binding protein-related factor 3) (TBP-related factor 3)	TBPL2 TBP2 TRF3	Homo sapiens (Human)	375	FUNCTION: Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity). {ECO:0000250|UniProtKB:Q6SJ95}.		DNA-templated transcription initiation [GO:0006352]	cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; nucleus [GO:0005634]	DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; nucleus [GO:0005634]; DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; DNA-templated transcription initiation [GO:0006352]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14634207}. Nucleus {ECO:0000269|PubMed:14634207}. Note=Present in the cytoplasm during cytokinesis. {ECO:0000269|PubMed:14634207}.
Q6T310	reviewed	RSLBA_HUMAN	Ras-like protein family member 11A (EC 3.6.5.2)	RASL11A	Homo sapiens (Human)	242	FUNCTION: Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity). {ECO:0000250}.		positive regulation of transcription by RNA polymerase I [GO:0045943]	nucleolus [GO:0005730]	G protein activity [GO:0003925]; GTP binding [GO:0005525]	nucleolus [GO:0005730]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; positive regulation of transcription by RNA polymerase I [GO:0045943]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Note=Associates with rDNA transcription unit throughout the cell cycle. {ECO:0000250}.
Q6T4P5	reviewed	PLPR3_HUMAN	Phospholipid phosphatase-related protein type 3 (Inactive phospholipid phosphatase PLPPR3) (Lipid phosphate phosphatase-related protein type 3) (PAP-2-like protein 2) (Plasticity-related gene 2 protein) (PRG-2)	PLPPR3 LPPR3 PHP2 PRG2	Homo sapiens (Human)	718			phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165]	membrane [GO:0016020]	phosphatidate phosphatase activity [GO:0008195]	membrane [GO:0016020]; phosphatidate phosphatase activity [GO:0008195]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6TDP4	reviewed	KLH17_HUMAN	Kelch-like protein 17 (Actinfilin)	KLHL17 AF	Homo sapiens (Human)	642	FUNCTION: Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). {ECO:0000250}.		actin cytoskeleton organization [GO:0030036]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]	actin cytoskeleton [GO:0015629]; dendrite cytoplasm [GO:0032839]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]	actin filament binding [GO:0051015]; molecular adaptor activity [GO:0060090]; POZ domain binding [GO:0031208]	actin cytoskeleton [GO:0015629]; dendrite cytoplasm [GO:0032839]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; actin filament binding [GO:0051015]; molecular adaptor activity [GO:0060090]; POZ domain binding [GO:0031208]; actin cytoskeleton organization [GO:0030036]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]	SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250|UniProtKB:Q8K430}. Synapse {ECO:0000250|UniProtKB:Q8K430}.
Q6TDU7	reviewed	DNAI7_HUMAN	Dynein axonemal intermediate chain 7 (Cancer susceptibility candidate gene 1 protein) (Protein CASC1) (Cilia and flagella associated protein 94) (Lung adenoma susceptibility 1-like protein) (Protein phosphatase 1 regulatory subunit 54)	DNAI7 CASC1 CFAP94 LAS1 PPP1R54	Homo sapiens (Human)	716	FUNCTION: Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function. May also act as a cell cycle regulator. {ECO:0000250|UniProtKB:Q6TDU8}.			axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; cilium [GO:0005929]	beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]	axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; cilium [GO:0005929]; beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q6TDU8}. Cytoplasm {ECO:0000250|UniProtKB:Q6TDU8}. Note=Colocalizes with microtubules in interphase. {ECO:0000250|UniProtKB:Q6TDU8}.
Q6UW32	reviewed	IGFL1_HUMAN	Insulin growth factor-like family member 1	IGFL1 UNQ644/PRO1274	Homo sapiens (Human)	110	FUNCTION: Probable ligand of the IGFLR1 cell membrane receptor. {ECO:0000269|PubMed:21454693}.			extracellular space [GO:0005615]	signaling receptor binding [GO:0005102]	extracellular space [GO:0005615]; signaling receptor binding [GO:0005102]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16890402, ECO:0000269|PubMed:21454693}.
Q6UW49	reviewed	SPESP_HUMAN	Sperm equatorial segment protein 1 (SP-ESP) (Equatorial segment protein) (ESP) (Glycosylated 38 kDa sperm protein C-7/8)	SPESP1 UNQ732/PRO1418	Homo sapiens (Human)	350	FUNCTION: Involved in fertilization ability of sperm. {ECO:0000250|UniProtKB:Q9D5A0}.		acrosome reaction [GO:0007340]; fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; sperm-egg recognition [GO:0035036]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]		acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; acrosome reaction [GO:0007340]; fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; sperm-egg recognition [GO:0035036]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:12773409}. Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase) (PubMed:12773409). After acrosome reaction localizes to the equatorial segment region in both noncapacitated and capacitated, acrosome-reacted sperm (By similarity). {ECO:0000250|UniProtKB:Q9D5A0, ECO:0000269|PubMed:12773409}.
Q6UWD8	reviewed	CP054_HUMAN	Transmembrane protein C16orf54	C16orf54 UNQ9389/PRO34280	Homo sapiens (Human)	224				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6UWJ1	reviewed	TMCO3_HUMAN	Transmembrane and coiled-coil domain-containing protein 3 (Putative LAG1-interacting protein)	TMCO3 C13orf11 UNQ2419/PRO4976	Homo sapiens (Human)	677	FUNCTION: Probable Na(+)/H(+) antiporter. {ECO:0000250}.			membrane [GO:0016020]	potassium:proton antiporter activity [GO:0015386]	membrane [GO:0016020]; potassium:proton antiporter activity [GO:0015386]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6UWL2	reviewed	SUSD1_HUMAN	Sushi domain-containing protein 1	SUSD1 UNQ2438/PRO4999	Homo sapiens (Human)	747				membrane [GO:0016020]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6UWM5	reviewed	GPRL1_HUMAN	GLIPR1-like protein 1	GLIPR1L1 UNQ2972/PRO7434	Homo sapiens (Human)	242	FUNCTION: Required for optimal fertilization at the stage of sperm-oocyte fusion, plays a role in optimizing acrosome function, the translocation of IZUMO1 during the acrosome reaction and the fertilization process. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region. {ECO:0000250|UniProtKB:Q32LB5, ECO:0000250|UniProtKB:Q9DAG6}.		fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein complex involved in cell-cell adhesion [GO:0098635]; side of membrane [GO:0098552]		acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein complex involved in cell-cell adhesion [GO:0098635]; side of membrane [GO:0098552]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9DAG6}. Cell membrane {ECO:0000250|UniProtKB:Q9DAG6}; Lipid-anchor, GPI-anchor {ECO:0000255}; Extracellular side {ECO:0000250|UniProtKB:Q9DAG6}. Membrane raft {ECO:0000250|UniProtKB:Q32LB5}. Secreted {ECO:0000250|UniProtKB:Q9DAG6}. Note=Located in the connecting piece of elongated spermatids and sperm. Also located in the apical region of the sperm head after sperm capacitation (By similarity). Weakly attached to the cell membrane and later secreted into the extracellular space (By similarity). Located on sperm equatorial segment and neck (By similarity). Associated with epididymosomes from the caput and cauda epididymis (By similarity). {ECO:0000250|UniProtKB:Q32LB5, ECO:0000250|UniProtKB:Q9DAG6}.
Q6UWM7	reviewed	LCTL_HUMAN	Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)	LCTL KLPH UNQ3022/PRO9820	Homo sapiens (Human)	567	FUNCTION: Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. {ECO:0000250|UniProtKB:Q8K1F9}.		carbohydrate metabolic process [GO:0005975]; lens morphogenesis in camera-type eye [GO:0002089]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	brush border [GO:0005903]; endoplasmic reticulum membrane [GO:0005789]	beta-glucosidase activity [GO:0008422]	brush border [GO:0005903]; endoplasmic reticulum membrane [GO:0005789]; beta-glucosidase activity [GO:0008422]; carbohydrate metabolic process [GO:0005975]; lens morphogenesis in camera-type eye [GO:0002089]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q6UWQ7	reviewed	IGFL2_HUMAN	Insulin growth factor-like family member 2	IGFL2 UNQ645/PRO1275	Homo sapiens (Human)	119	FUNCTION: Potential ligand of the IGFLR1 cell membrane receptor. {ECO:0000269|PubMed:21454693}.			extracellular space [GO:0005615]	signaling receptor binding [GO:0005102]	extracellular space [GO:0005615]; signaling receptor binding [GO:0005102]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UWT4	reviewed	CE046_HUMAN	Uncharacterized protein C5orf46	C5orf46 UNQ472/PRO839	Homo sapiens (Human)	87				extracellular exosome [GO:0070062]		extracellular exosome [GO:0070062]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UWV2	reviewed	MPZL3_HUMAN	Myelin protein zero-like protein 3	MPZL3 UNQ2966/PRO7425	Homo sapiens (Human)	235	FUNCTION: Mediates homophilic cell-cell adhesion. {ECO:0000250}.		cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; hair cycle [GO:0042633]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; hair cycle [GO:0042633]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6UWW9	reviewed	TM207_HUMAN	Transmembrane protein 207	TMEM207 UNQ846/PRO1784	Homo sapiens (Human)	146				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6UX07	reviewed	DHR13_HUMAN	Dehydrogenase/reductase SDR family member 13 (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 7C member 5) (Protein SDR7C5)	DHRS13 SDR7C5 UNQ419/PRO853	Homo sapiens (Human)	377	FUNCTION: Putative oxidoreductase. {ECO:0000305}.			extracellular region [GO:0005576]; membrane [GO:0016020]	oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]; membrane [GO:0016020]; oxidoreductase activity [GO:0016491]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UX52	reviewed	IL40_HUMAN	Protein IL-40 (Interleukin-40) (IL-40)	C17orf99 IL40 UNQ464/PRO809	Homo sapiens (Human)	265	FUNCTION: Probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses. Involved in lymphocyte B cell development and immunoglobulin/IgA production. {ECO:0000250|UniProtKB:Q9CX63}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; mature B cell differentiation involved in immune response [GO:0002313]; positive regulation of immunoglobulin production in mucosal tissue [GO:2000558]; regulation of immune response [GO:0050776]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]; transmembrane signaling receptor activity [GO:0004888]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; mature B cell differentiation involved in immune response [GO:0002313]; positive regulation of immunoglobulin production in mucosal tissue [GO:2000558]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28978694}.
Q6UX53	reviewed	TMT1B_HUMAN	Thiol S-methyltransferase TMT1B (EC 2.1.1.9) (Methyltransferase-like protein 7B) (Thiol S-methyltransferase METTL7B)	TMT1B METTL7B UNQ594/PRO1180	Homo sapiens (Human)	244	FUNCTION: Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-l-methionine to hydrogen sulfide and other thiol compounds including dithiothreitol, 7alpha-thiospironolactone, L-penicillamine, and captopril. {ECO:0000269|PubMed:33649426}.		methylation [GO:0032259]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]	methyltransferase activity [GO:0008168]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; thiol S-methyltransferase activity [GO:0018708]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; methyltransferase activity [GO:0008168]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; thiol S-methyltransferase activity [GO:0018708]; methylation [GO:0032259]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q562C4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q562C4}. Lipid droplet {ECO:0000250|UniProtKB:Q562C4}. Note=Highly concentrated in the perinuclear area of the endoplasmic reticulum (ER) and surrounding lipid droplets. May be associated with the specific regions of the LR that form lipid droplets and targeted to the initial deposits of lipids where the lipid droplets form. {ECO:0000250|UniProtKB:Q562C4}.
Q6UX73	reviewed	CP089_HUMAN	UPF0764 protein C16orf89	C16orf89 UNQ904/PRO1925	Homo sapiens (Human)	402		MISCELLANEOUS: [Isoform 2]: Major isoform, represents 80% of transcripts. {ECO:0000305}.		cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; protein homodimerization activity [GO:0042803]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20578903}.
Q6UXA7	reviewed	CF015_HUMAN	Uncharacterized protein C6orf15 (Protein STG)	C6orf15 STG UNQ1840/PRO3566	Homo sapiens (Human)	325			extracellular matrix organization [GO:0030198]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]		extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q6UXC1	reviewed	AEGP_HUMAN	Apical endosomal glycoprotein (MAM domain-containing protein 4)	MAMDC4 AEGP UNQ3001/PRO9742	Homo sapiens (Human)	1216	FUNCTION: Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. {ECO:0000250|UniProtKB:Q63191}.	MISCELLANEOUS: [Isoform 1]: Gene prediction based on similarity to rat ortholog.; MISCELLANEOUS: [Isoform 3]: May be due to intron retention. {ECO:0000305}.	protein transport [GO:0015031]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]		Golgi apparatus [GO:0005794]; membrane [GO:0016020]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q6UXH9	reviewed	PAMR1_HUMAN	Inactive serine protease PAMR1 (Peptidase domain-containing protein associated with muscle regeneration 1) (Regeneration-associated muscle protease homolog)	PAMR1 RAMP FP938 UNQ699/PRO1344	Homo sapiens (Human)	720	FUNCTION: May play a role in regeneration of skeletal muscle. {ECO:0000250}.			extracellular region [GO:0005576]	calcium ion binding [GO:0005509]	extracellular region [GO:0005576]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UXI7	reviewed	VITRN_HUMAN	Vitrin	VIT UNQ647/PRO1277	Homo sapiens (Human)	678	FUNCTION: Promotes matrix assembly and cell adhesiveness. Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells. {ECO:0000250|UniProtKB:Q8VHI5}.		extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]; spinal cord development [GO:0021510]	extracellular region [GO:0005576]; interstitial matrix [GO:0005614]	glycosaminoglycan binding [GO:0005539]	extracellular region [GO:0005576]; interstitial matrix [GO:0005614]; glycosaminoglycan binding [GO:0005539]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]; spinal cord development [GO:0021510]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q6UXK5	reviewed	LRRN1_HUMAN	Leucine-rich repeat neuronal protein 1 (Neuronal leucine-rich repeat protein 1) (NLRR-1)	LRRN1 KIAA1497 Nbla10449 UNQ693/PRO1338	Homo sapiens (Human)	716			positive regulation of synapse assembly [GO:0051965]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; positive regulation of synapse assembly [GO:0051965]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6UXM1	reviewed	LRIG3_HUMAN	Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3)	LRIG3 LIG3 UNQ287/PRO326/PRO335	Homo sapiens (Human)	1119	FUNCTION: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). {ECO:0000250}.		otolith morphogenesis [GO:0032474]	cytoplasmic vesicle membrane [GO:0030659]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]		cytoplasmic vesicle membrane [GO:0030659]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; otolith morphogenesis [GO:0032474]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4. {ECO:0000250}.
Q6UXN2	reviewed	TRML4_HUMAN	Trem-like transcript 4 protein (TLT-4) (Triggering receptor expressed on myeloid cells-like protein 4)	TREML4 TLT4 UNQ9425/PRO34675	Homo sapiens (Human)	200	FUNCTION: Positively regulates Toll-like receptor TLR7 signaling in macrophages. {ECO:0000269|PubMed:25848864}.		innate immune response [GO:0045087]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; innate immune response [GO:0045087]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]	SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24975946}.
Q6UXT9	reviewed	ABH15_HUMAN	Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15)	ABHD15 UNQ6510/PRO21435	Homo sapiens (Human)	468	FUNCTION: May regulate adipocyte lipolysis and liver lipid accumulation. {ECO:0000250|UniProtKB:Q5F2F2}.		adipose tissue development [GO:0060612]; cellular lipid metabolic process [GO:0044255]; lipid catabolic process [GO:0016042]	extracellular region [GO:0005576]; membrane [GO:0016020]	acylglycerol lipase activity [GO:0047372]; short-chain carboxylesterase activity [GO:0034338]	extracellular region [GO:0005576]; membrane [GO:0016020]; acylglycerol lipase activity [GO:0047372]; short-chain carboxylesterase activity [GO:0034338]; adipose tissue development [GO:0060612]; cellular lipid metabolic process [GO:0044255]; lipid catabolic process [GO:0016042]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UXX5	reviewed	ITIH6_HUMAN	Inter-alpha-trypsin inhibitor heavy chain H6 (Inter-alpha-trypsin inhibitor heavy chain H5-like protein) (Inter-alpha inhibitor H5-like protein)	ITIH6 ITIH5L UNQ6369/PRO21074	Homo sapiens (Human)	1313			hyaluronan metabolic process [GO:0030212]	extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]; hyaluronan metabolic process [GO:0030212]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q6UY11	reviewed	DLK2_HUMAN	Protein delta homolog 2 (DLK-2) (Epidermal growth factor-like protein 9) (EGF-like protein 9)	DLK2 EGFL9 UNQ2903/PRO28633	Homo sapiens (Human)	383	FUNCTION: Regulates adipogenesis. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: Splicing acceptor site not canonical. {ECO:0000305}.	negative regulation of Notch signaling pathway [GO:0045746]; regulation of fat cell differentiation [GO:0045598]	membrane [GO:0016020]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; Notch binding [GO:0005112]	membrane [GO:0016020]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; Notch binding [GO:0005112]; negative regulation of Notch signaling pathway [GO:0045746]; regulation of fat cell differentiation [GO:0045598]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6V1P9	reviewed	PCD23_HUMAN	Protocadherin-23 (Cadherin-27) (Cadherin-like protein CDHJ) (Cadherin-like protein VR8) (Protein dachsous homolog 2) (Protocadherin PCDHJ)	DCHS2 CDH27 CDHJ PCDH23 PCDHJ	Homo sapiens (Human)	3371	FUNCTION: Calcium-dependent cell-adhesion protein. {ECO:0000250}.		cell-cell adhesion [GO:0098609]; condensed mesenchymal cell proliferation [GO:0072137]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nephron development [GO:0072006]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell-cell adhesion [GO:0098609]; condensed mesenchymal cell proliferation [GO:0072137]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nephron development [GO:0072006]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q6VUC0	reviewed	AP2E_HUMAN	Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon)	TFAP2E	Homo sapiens (Human)	442	FUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}.		anatomical structure development [GO:0048856]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure development [GO:0048856]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6VUP9}.
Q6W3E5	reviewed	GDPD4_HUMAN	Glycerophosphodiester phosphodiesterase domain-containing protein 4 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 6) (UgpQ)	GDPD4 GDE6 UGPQ	Homo sapiens (Human)	623			lipid metabolic process [GO:0006629]	membrane [GO:0016020]	glycerophosphodiester phosphodiesterase activity [GO:0008889]; metal ion binding [GO:0046872]	membrane [GO:0016020]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; metal ion binding [GO:0046872]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6WBX8	reviewed	RAD9B_HUMAN	Cell cycle checkpoint control protein RAD9B (DNA repair exonuclease rad9 homolog B) (hRAD9B)	RAD9B	Homo sapiens (Human)	426			cellular response to ionizing radiation [GO:0071479]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]	checkpoint clamp complex [GO:0030896]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		checkpoint clamp complex [GO:0030896]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cellular response to ionizing radiation [GO:0071479]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]	
Q6X784	reviewed	ZPBP2_HUMAN	Zona pellucida-binding protein 2 (ZPBP-like protein)	ZPBP2 ZPBPL	Homo sapiens (Human)	338	FUNCTION: Is implicated in sperm-oocyte interaction during fertilization. {ECO:0000250|UniProtKB:Q6X786}.		acrosome assembly [GO:0001675]; binding of sperm to zona pellucida [GO:0007339]; circadian regulation of gene expression [GO:0032922]; membrane lipid catabolic process [GO:0046466]; negative regulation of immunoglobulin production [GO:0002638]; sphingolipid metabolic process [GO:0006665]	acrosomal vesicle [GO:0001669]; cell body [GO:0044297]; extracellular region [GO:0005576]; nucleus [GO:0005634]; zona pellucida receptor complex [GO:0002199]		acrosomal vesicle [GO:0001669]; cell body [GO:0044297]; extracellular region [GO:0005576]; nucleus [GO:0005634]; zona pellucida receptor complex [GO:0002199]; acrosome assembly [GO:0001675]; binding of sperm to zona pellucida [GO:0007339]; circadian regulation of gene expression [GO:0032922]; membrane lipid catabolic process [GO:0046466]; negative regulation of immunoglobulin production [GO:0002638]; sphingolipid metabolic process [GO:0006665]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q6X786}. Secreted {ECO:0000305}. Note=Released after the acrosomal reaction. {ECO:0000250|UniProtKB:Q6X786}.
Q6X9E4	reviewed	FBW12_HUMAN	F-box/WD repeat-containing protein 12 (F-box and WD-40 domain-containing protein 12) (F-box only protein 35)	FBXW12 FBW12 FBXO12 FBXO35	Homo sapiens (Human)	464	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (PubMed:26171402). Promotes degradation of interleukin-22 receptor subunit IL22RA1 in resting and IL22-stimulated conditions by facilitating its ubiquitination (PubMed:26171402). Functions as a cell growth suppressor (PubMed:26171402). {ECO:0000269|PubMed:26171402}.			cytosol [GO:0005829]		cytosol [GO:0005829]	
Q6XPR3	reviewed	RPTN_HUMAN	Repetin	RPTN	Homo sapiens (Human)	784	FUNCTION: Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium.			cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q6XYB7	reviewed	LBX2_HUMAN	Transcription factor LBX2 (Ladybird homeobox 2) (Ladybird homeobox protein homolog 2)	LBX2 LP3727	Homo sapiens (Human)	198	FUNCTION: Transcription factor. {ECO:0000250|UniProtKB:Q804R0}.		muscle cell differentiation [GO:0042692]; positive regulation of convergent extension involved in gastrulation [GO:1904105]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; muscle cell differentiation [GO:0042692]; positive regulation of convergent extension involved in gastrulation [GO:1904105]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q6YFQ2	reviewed	CX6B2_HUMAN	Cytochrome c oxidase subunit 6B2 (Cancer/testis antigen 59) (CT59) (Cytochrome c oxidase subunit VIb isoform 2) (COX VIb-2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)	COX6B2	Homo sapiens (Human)	88	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:Q01519}.		oxidative phosphorylation [GO:0006119]	mitochondrial crista [GO:0030061]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]		mitochondrial crista [GO:0030061]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]; oxidative phosphorylation [GO:0006119]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00429}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00429}; Intermembrane side {ECO:0000250|UniProtKB:P00429}.
Q6YI46	reviewed	TMM64_HUMAN	Transmembrane protein 64	TMEM64	Homo sapiens (Human)	380	FUNCTION: Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1. {ECO:0000250|UniProtKB:Q3U145}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of osteoblast differentiation [GO:0045668]; osteoclast differentiation [GO:0030316]; positive regulation of bone resorption [GO:0045780]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of osteoclast differentiation [GO:0045672]; regulation of cytosolic calcium ion concentration [GO:0051480]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]		endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of osteoblast differentiation [GO:0045668]; osteoclast differentiation [GO:0030316]; positive regulation of bone resorption [GO:0045780]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of osteoclast differentiation [GO:0045672]; regulation of cytosolic calcium ion concentration [GO:0051480]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q3U145}.
Q6ZMD2	reviewed	SPNS3_HUMAN	Protein spinster homolog 3	SPNS3	Homo sapiens (Human)	512	FUNCTION: Sphingolipid transporter. {ECO:0000250}.		lipid transport [GO:0006869]	membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]; lipid transport [GO:0006869]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZMR3	reviewed	LDH6A_HUMAN	L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27)	LDHAL6A LDHL2	Homo sapiens (Human)	332	FUNCTION: Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme (PubMed:18351441). Significantly increases the transcriptional activity of JUN, when overexpressed. {ECO:0000269|PubMed:18351441}.		lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	L-lactate dehydrogenase activity [GO:0004459]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; L-lactate dehydrogenase activity [GO:0004459]; lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18351441}.
Q6ZMV9	reviewed	KIF6_HUMAN	Kinesin-like protein KIF6	KIF6 C6orf102	Homo sapiens (Human)	814			microtubule-based movement [GO:0007018]	cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
Q6ZMY3	reviewed	SPOC1_HUMAN	SPOC domain-containing protein 1	SPOCD1	Homo sapiens (Human)	1216	FUNCTION: Essential excecutor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (By similarity). Associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (By similarity). Tethering of PIWIL4 to a nascent transposable element transcript recruits repressive chromatin remodeling activities and the de novo methylation apparatus through SPOCD1 (By similarity). Not required for piRNA biosynthesis (By similarity). {ECO:0000250|UniProtKB:B1ASB6}.		cell differentiation [GO:0030154]; DNA methylation [GO:0006306]; DNA-templated transcription [GO:0006351]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]	chromosome [GO:0005694]; nucleus [GO:0005634]		chromosome [GO:0005694]; nucleus [GO:0005634]; cell differentiation [GO:0030154]; DNA methylation [GO:0006306]; DNA-templated transcription [GO:0006351]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B1ASB6}. Chromosome {ECO:0000250|UniProtKB:B1ASB6}.
Q6ZN11	reviewed	ZN793_HUMAN	Zinc finger protein 793	ZNF793	Homo sapiens (Human)	406	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZN28	reviewed	MACC1_HUMAN	Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5)	MACC1	Homo sapiens (Human)	852	FUNCTION: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}.		positive regulation of cell division [GO:0051781]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	growth factor activity [GO:0008083]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; growth factor activity [GO:0008083]; positive regulation of cell division [GO:0051781]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19098908}. Nucleus {ECO:0000269|PubMed:19098908}. Note=Mainly found in the cytoplasm in non-metastasizing tumors.
Q6ZN54	reviewed	DEFI8_HUMAN	Differentially expressed in FDCP 8 homolog (DEF-8)	DEF8	Homo sapiens (Human)	512	FUNCTION: Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. {ECO:0000250|UniProtKB:Q99J78}.		lysosome localization [GO:0032418]; positive regulation of bone resorption [GO:0045780]; positive regulation of ruffle assembly [GO:1900029]		metal ion binding [GO:0046872]	metal ion binding [GO:0046872]; lysosome localization [GO:0032418]; positive regulation of bone resorption [GO:0045780]; positive regulation of ruffle assembly [GO:1900029]	
Q6ZNB6	reviewed	NFXL1_HUMAN	NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP)	NFXL1 OZFP	Homo sapiens (Human)	911		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	regulation of DNA-templated transcription [GO:0006355]	chromatin [GO:0000785]; membrane [GO:0016020]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; membrane [GO:0016020]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6ZNW5	reviewed	GDPP1_HUMAN	GDP-D-glucose phosphorylase 1 (EC 2.7.7.78)	GDPGP1 C15orf58	Homo sapiens (Human)	385	FUNCTION: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. {ECO:0000269|PubMed:21507950}.	MISCELLANEOUS: The orthologs in A.thaliana are GDP-L-galactose phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.	glucose metabolic process [GO:0006006]	cytoplasm [GO:0005737]	GDP-D-glucose phosphorylase activity [GO:0080048]; guanyl-nucleotide exchange factor activity [GO:0005085]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166]	cytoplasm [GO:0005737]; GDP-D-glucose phosphorylase activity [GO:0080048]; guanyl-nucleotide exchange factor activity [GO:0005085]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166]; glucose metabolic process [GO:0006006]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q6ZP65	reviewed	BICL1_HUMAN	BICD family-like cargo adapter 1 (Bicaudal D-related protein 1) (BICD-related protein 1) (BICDR-1) (Coiled-coil domain-containing protein 64A) (CCDC64A)	BICDL1 BICDR1 CCDC64	Homo sapiens (Human)	573	FUNCTION: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis. {ECO:0000250|UniProtKB:A0JNT9}.		Golgi to secretory granule transport [GO:0055107]; neuron projection development [GO:0031175]; vesicle transport along microtubule [GO:0047496]	centrosome [GO:0005813]; cytoplasm [GO:0005737]	dynactin binding [GO:0034452]; small GTPase binding [GO:0031267]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; dynactin binding [GO:0034452]; small GTPase binding [GO:0031267]; Golgi to secretory granule transport [GO:0055107]; neuron projection development [GO:0031175]; vesicle transport along microtubule [GO:0047496]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0JNT9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:A0JNT9}. Note=Localizes around the centrosome. {ECO:0000250|UniProtKB:A0JNT9}.
Q6ZQR2	reviewed	CFA77_HUMAN	Cilia- and flagella-associated protein 77	CFAP77 C9orf171	Homo sapiens (Human)	320	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.			axonemal microtubule [GO:0005879]		axonemal microtubule [GO:0005879]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q6ZR52	reviewed	ZN493_HUMAN	Zinc finger protein 493	ZNF493	Homo sapiens (Human)	646	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZRH7	reviewed	CTSRG_HUMAN	Cation channel sperm-associated auxiliary subunit gamma	CATSPERG C19orf15	Homo sapiens (Human)	1159	FUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. {ECO:0000250|UniProtKB:C6KI89}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	CatSper complex [GO:0036128]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]		CatSper complex [GO:0036128]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
Q6ZS27	reviewed	ZN662_HUMAN	Zinc finger protein 662	ZNF662	Homo sapiens (Human)	426	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q6ZS72	reviewed	PEAK3_HUMAN	Protein PEAK3	PEAK3 C19orf35	Homo sapiens (Human)	473	FUNCTION: Probable catalytically inactive kinase (Probable). Interacts with CRK-II and antagonizes CRK-II-signaling. Prevents the formation of CRK-II-dependent membrane ruffling and lamellipodia-like extensions (PubMed:31311869). {ECO:0000269|PubMed:31311869, ECO:0000305|PubMed:31311869}.		regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]	actin cytoskeleton [GO:0015629]; focal adhesion [GO:0005925]	protein kinase activity [GO:0004672]; protein self-association [GO:0043621]	actin cytoskeleton [GO:0015629]; focal adhesion [GO:0005925]; protein kinase activity [GO:0004672]; protein self-association [GO:0043621]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]	
Q6ZS81	reviewed	WDFY4_HUMAN	WD repeat- and FYVE domain-containing protein 4	WDFY4 C10orf64 KIAA1607	Homo sapiens (Human)	3184	FUNCTION: Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Also plays a role in B-cell survival through regulation of autophagy. {ECO:0000250|UniProtKB:E9Q2M9}.		antigen processing and presentation [GO:0019882]; autophagy [GO:0006914]; CD8-positive, alpha-beta T cell activation [GO:0036037]; cellular response to virus [GO:0098586]	early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]		early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; antigen processing and presentation [GO:0019882]; autophagy [GO:0006914]; CD8-positive, alpha-beta T cell activation [GO:0036037]; cellular response to virus [GO:0098586]	SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:E9Q2M9}. Endoplasmic reticulum {ECO:0000250|UniProtKB:E9Q2M9}.
Q6ZSG2	reviewed	INSY2_HUMAN	Inhibitory synaptic factor 2A (InSyn2)	INSYN2A C10orf141 FAM196A INSYN2	Homo sapiens (Human)	479	FUNCTION: Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. {ECO:0000250|UniProtKB:Q3USH1}.		inhibitory postsynaptic potential [GO:0060080]	postsynaptic density [GO:0014069]		postsynaptic density [GO:0014069]; inhibitory postsynaptic potential [GO:0060080]	SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250|UniProtKB:Q3USH1}.
Q6ZTA4	reviewed	TRI67_HUMAN	Tripartite motif-containing protein 67 (TRIM9-like protein)	TRIM67 TNL	Homo sapiens (Human)	783			negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; regulation of protein localization [GO:0032880]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; zinc ion binding [GO:0008270]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; regulation of protein localization [GO:0032880]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Microtubule-associated. {ECO:0000250}.
Q6ZTI6	reviewed	RFLA_HUMAN	Refilin-A (Regulator of filamin protein A) (RefilinA)	RFLNA FAM101A	Homo sapiens (Human)	216	FUNCTION: Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells. {ECO:0000250|UniProtKB:Q7TS73}.		actin filament bundle organization [GO:0061572]; negative regulation of bone mineralization involved in bone maturation [GO:1900158]; negative regulation of chondrocyte development [GO:0061182]; skeletal system morphogenesis [GO:0048705]	actin filament bundle [GO:0032432]; cytoplasm [GO:0005737]	filamin binding [GO:0031005]	actin filament bundle [GO:0032432]; cytoplasm [GO:0005737]; filamin binding [GO:0031005]; actin filament bundle organization [GO:0061572]; negative regulation of bone mineralization involved in bone maturation [GO:1900158]; negative regulation of chondrocyte development [GO:0061182]; skeletal system morphogenesis [GO:0048705]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q7TS73}. Note=Colocalizes with FLNA along actin bundle-like structures. {ECO:0000250|UniProtKB:Q7TS73}.
Q6ZTQ3	reviewed	RASF6_HUMAN	Ras association domain-containing protein 6	RASSF6	Homo sapiens (Human)	369	FUNCTION: Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity). {ECO:0000250, ECO:0000269|PubMed:17367779}.		apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165]			apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165]	
Q6ZTR7	reviewed	CBAR2_HUMAN	CBY1-interacting BAR domain-containing protein 2 (Protein FAM92B)	CIBAR2 FAM92B	Homo sapiens (Human)	304	FUNCTION: May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616). {ECO:0000250|UniProtKB:A1XBS5, ECO:0000269|PubMed:27528616}.		cilium assembly [GO:0060271]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]		centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q3V2J0}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q3V2J0}. Note=Extensive colocalization with CBY1 at mother centrioles. {ECO:0000250|UniProtKB:Q3V2J0}.
Q6ZTW0	reviewed	TPGS1_HUMAN	Tubulin polyglutamylase complex subunit 1 (PGs1)	TPGS1 C19orf20	Homo sapiens (Human)	290	FUNCTION: Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility (Probable). May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity). {ECO:0000250|UniProtKB:Q99MS8, ECO:0000305|PubMed:34782749}.		adult behavior [GO:0030534]; chemical synaptic transmission [GO:0007268]; sperm axoneme assembly [GO:0007288]; vesicle localization [GO:0051648]	axon [GO:0030424]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; microtubule [GO:0005874]; motile cilium [GO:0031514]; synapse [GO:0045202]	microtubule binding [GO:0008017]; tubulin-glutamic acid ligase activity [GO:0070740]	axon [GO:0030424]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; microtubule [GO:0005874]; motile cilium [GO:0031514]; synapse [GO:0045202]; microtubule binding [GO:0008017]; tubulin-glutamic acid ligase activity [GO:0070740]; adult behavior [GO:0030534]; chemical synaptic transmission [GO:0007268]; sperm axoneme assembly [GO:0007288]; vesicle localization [GO:0051648]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q99MS8}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q99MS8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q99MS8}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250|UniProtKB:Q99MS8}. Cell projection, axon {ECO:0000250|UniProtKB:Q99MS8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99MS8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q99MS8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:34782749}. Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes. {ECO:0000250|UniProtKB:Q99MS8}.
Q6ZUB1	reviewed	S31E1_HUMAN	Spermatogenesis-associated protein 31E1 (Protein FAM75E1)	SPATA31E1 C9orf79 FAM75E1	Homo sapiens (Human)	1445	FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6ZUT9	reviewed	DEN5B_HUMAN	DENN domain-containing protein 5B (Rab6IP1-like protein)	DENND5B	Homo sapiens (Human)	1274	FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.		positive regulation of triglyceride transport [GO:1905885]	cytosol [GO:0005829]; membrane [GO:0016020]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; membrane [GO:0016020]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; positive regulation of triglyceride transport [GO:1905885]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6ZUV0	reviewed	BACHL_HUMAN	Putative cytosolic acyl coenzyme A thioester hydrolase-like (EC 3.1.2.2) (Acyl-CoA thioesterase 7-like)	ACOT7L BACHL	Homo sapiens (Human)	252	FUNCTION: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. {ECO:0000250}.		acyl-CoA metabolic process [GO:0006637]; palmitic acid biosynthetic process [GO:1900535]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	carboxylic ester hydrolase activity [GO:0052689]; long-chain fatty acyl-CoA binding [GO:0036042]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; carboxylic ester hydrolase activity [GO:0052689]; long-chain fatty acyl-CoA binding [GO:0036042]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; acyl-CoA metabolic process [GO:0006637]; palmitic acid biosynthetic process [GO:1900535]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q6ZUX3	reviewed	TGRM2_HUMAN	TOG array regulator of axonemal microtubules protein 2 (Crescerin-2)	TOGARAM2 FAM179A	Homo sapiens (Human)	1019			microtubule cytoskeleton organization [GO:0000226]; regulation of cellular component organization [GO:0051128]	cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881]	microtubule binding [GO:0008017]	cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881]; microtubule binding [GO:0008017]; microtubule cytoskeleton organization [GO:0000226]; regulation of cellular component organization [GO:0051128]	
Q6ZVH7	reviewed	ESPNL_HUMAN	Espin-like protein	ESPNL	Homo sapiens (Human)	1005	FUNCTION: Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. {ECO:0000250|UniProtKB:Q3UYR4}.		actin filament bundle assembly [GO:0051017]; sensory perception of sound [GO:0007605]	cytoplasm [GO:0005737]; stereocilium tip [GO:0032426]	actin filament binding [GO:0051015]	cytoplasm [GO:0005737]; stereocilium tip [GO:0032426]; actin filament binding [GO:0051015]; actin filament bundle assembly [GO:0051017]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000250|UniProtKB:Q3UYR4}.
Q6ZVX7	reviewed	FBX50_HUMAN	F-box only protein 50 (NCC receptor protein 1 homolog) (NCCRP-1) (Non-specific cytotoxic cell receptor protein 1 homolog)	NCCRP1 FBXO50	Homo sapiens (Human)	275	FUNCTION: Promotes cell proliferation. {ECO:0000269|PubMed:22087255}.		glycoprotein catabolic process [GO:0006516]; positive regulation of cell population proliferation [GO:0008284]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; SCF ubiquitin ligase complex [GO:0019005]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; SCF ubiquitin ligase complex [GO:0019005]; glycoprotein catabolic process [GO:0006516]; positive regulation of cell population proliferation [GO:0008284]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22087255}.
Q6ZVX9	reviewed	PAQR9_HUMAN	Membrane progestin receptor epsilon (mPR epsilon) (Membrane progesterone P4 receptor epsilon) (Membrane progesterone receptor epsilon) (Progesterone and adipoQ receptor family member 9) (Progestin and adipoQ receptor family member 9) (Progestin and adipoQ receptor family member IX)	PAQR9	Homo sapiens (Human)	377	FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870). {ECO:0000269|PubMed:23161870, ECO:0000303|PubMed:23763432}.	MISCELLANEOUS: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). {ECO:0000303|PubMed:23763432}.		plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]; steroid binding [GO:0005496]	plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; steroid binding [GO:0005496]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23161870}; Multi-pass membrane protein {ECO:0000255}.
Q6ZW05	reviewed	PTHD4_HUMAN	Patched domain-containing protein 4 (p53-regulated patched protein)	PTCHD4 C6orf138 PTCH53	Homo sapiens (Human)	846	FUNCTION: Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells. {ECO:0000269|PubMed:25296753}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZWE6	reviewed	PKHM3_HUMAN	Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) (Differentiation associated protein)	PLEKHM3 DAPR PLEKHM1L	Homo sapiens (Human)	761	FUNCTION: Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation. {ECO:0000250|UniProtKB:Q8BM47}.		myoblast differentiation [GO:0045445]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; myoblast differentiation [GO:0045445]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BM47}. Golgi apparatus {ECO:0000250|UniProtKB:Q8BM47}. Cell membrane {ECO:0000250|UniProtKB:Q8BM47}. Note=Before differentiation of muscle cells, localized to the Golgi apparatus. During muscle differentiation shuttles to the plasma membrane. {ECO:0000250|UniProtKB:Q8BM47}.
Q6ZWJ8	reviewed	KCP_HUMAN	Kielin/chordin-like protein (Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1)	KCP CRIM2 KCP1	Homo sapiens (Human)	1568	FUNCTION: Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	positive regulation of BMP signaling pathway [GO:0030513]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; positive regulation of BMP signaling pathway [GO:0030513]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q6ZWK6	reviewed	TM11F_HUMAN	Transmembrane protease serine 11F (EC 3.4.21.-) (Airway trypsin-like protease 4)	TMPRSS11F HATL4	Homo sapiens (Human)	438	FUNCTION: Probable serine protease. {ECO:0000250}.		establishment of skin barrier [GO:0061436]; proteolysis [GO:0006508]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; establishment of skin barrier [GO:0061436]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q701N2	reviewed	KRA55_HUMAN	Keratin-associated protein 5-5 (Keratin-associated protein 5-11) (Keratin-associated protein 5.11) (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5)	KRTAP5-5 KAP5-11 KAP5.5 KRTAP5-11 KRTAP5.11 KRTAP5.5	Homo sapiens (Human)	237	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q711Q0	reviewed	CEFIP_HUMAN	Cardiac-enriched FHL2-interacting protein	CEFIP C10orf71	Homo sapiens (Human)	1435	FUNCTION: Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}.		positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]	Z disc [GO:0030018]		Z disc [GO:0030018]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:M0RD54}.
Q717R9	reviewed	CYS1_HUMAN	Cystin-1 (Cilia-associated protein)	CYS1	Homo sapiens (Human)	158				ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]		ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:22085962}; Lipid-anchor {ECO:0000269|PubMed:22085962}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:22085962}. Note=Expression is enriched in the ciliary axoneme. Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus.
Q71RH2	reviewed	TLC3B_HUMAN	Ceramide synthase (EC 2.3.1.-) (Protein FAM57B) (TLC domain-containing protein 3B)	TLCD3B FAM57B FP1188	Homo sapiens (Human)	274	FUNCTION: Involved in ceramide synthesis. {ECO:0000250}.		ceramide biosynthetic process [GO:0046513]; lipid homeostasis [GO:0055088]; negative regulation of fat cell differentiation [GO:0045599]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	sphingosine N-acyltransferase activity [GO:0050291]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; sphingosine N-acyltransferase activity [GO:0050291]; ceramide biosynthetic process [GO:0046513]; lipid homeostasis [GO:0055088]; negative regulation of fat cell differentiation [GO:0045599]	SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q7TNV1}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7TNV1}; Multi-pass membrane protein {ECO:0000255}.
Q76B58	reviewed	BRNP3_HUMAN	BMP/retinoic acid-inducible neural-specific protein 3 (DBCCR1-like protein 1)	BRINP3 DBCCR1L DBCCR1L1 FAM5C	Homo sapiens (Human)	766	FUNCTION: Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development. {ECO:0000269|PubMed:17138656}.		cell cycle [GO:0007049]; cellular response to retinoic acid [GO:0071300]; central nervous system neuron differentiation [GO:0021953]; negative regulation of mitotic cell cycle [GO:0045930]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]		cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; cell cycle [GO:0007049]; cellular response to retinoic acid [GO:0071300]; central nervous system neuron differentiation [GO:0021953]; negative regulation of mitotic cell cycle [GO:0045930]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Mitochondrion {ECO:0000250}.
Q76KP1	reviewed	B4GN4_HUMAN	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 (NGalNAc-T1) (EC 2.4.1.244) (Beta-1,4-N-acetylgalactosaminyltransferase IV) (Beta4GalNAc-T4) (Beta4GalNAcT4)	B4GALNT4	Homo sapiens (Human)	1039	FUNCTION: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.			Golgi cisterna membrane [GO:0032580]	acetylgalactosaminyltransferase activity [GO:0008376]; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842]	Golgi cisterna membrane [GO:0032580]; acetylgalactosaminyltransferase activity [GO:0008376]; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q7L0R7	reviewed	RNF44_HUMAN	RING finger protein 44	RNF44 KIAA1100	Homo sapiens (Human)	432			protein ubiquitination [GO:0016567]		metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]	
Q7L1V2	reviewed	MON1B_HUMAN	Vacuolar fusion protein MON1 homolog B (HSV-1 stimulation-related gene 1 protein) (HSV-I stimulating-related protein)	MON1B HSRG1 KIAA0872 SAND2	Homo sapiens (Human)	547			early viral transcription [GO:0019085]; late viral transcription [GO:0019086]; protein targeting to vacuole [GO:0006623]; vesicle-mediated transport [GO:0016192]	cytoplasm [GO:0005737]; Mon1-Ccz1 complex [GO:0035658]		cytoplasm [GO:0005737]; Mon1-Ccz1 complex [GO:0035658]; early viral transcription [GO:0019085]; late viral transcription [GO:0019086]; protein targeting to vacuole [GO:0006623]; vesicle-mediated transport [GO:0016192]	
Q7L2K0	reviewed	TEDC2_HUMAN	Tubulin epsilon and delta complex protein 2	TEDC2 C16orf59	Homo sapiens (Human)	433	FUNCTION: Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability. {ECO:0000250|UniProtKB:Q6GQV0}.		positive regulation of smoothened signaling pathway [GO:0045880]	centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737]		centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737]; positive regulation of smoothened signaling pathway [GO:0045880]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q6GQV0}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q6GQV0}.
Q7L3S4	reviewed	ZN771_HUMAN	Zinc finger protein 771 (Mesenchymal stem cell protein DSC43)	ZNF771	Homo sapiens (Human)	317	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q7L3T8	reviewed	SYPM_HUMAN	Probable proline--tRNA ligase, mitochondrial (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)	PARS2	Homo sapiens (Human)	475			prolyl-tRNA aminoacylation [GO:0006433]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; proline-tRNA ligase activity [GO:0004827]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; proline-tRNA ligase activity [GO:0004827]; prolyl-tRNA aminoacylation [GO:0006433]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305}.
Q7L8C5	reviewed	SYT13_HUMAN	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII)	SYT13 KIAA1427	Homo sapiens (Human)	426	FUNCTION: May be involved in transport vesicle docking to the plasma membrane. {ECO:0000250}.		calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]	exocytic vesicle [GO:0070382]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]	exocytic vesicle [GO:0070382]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]; calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q7L8W6	reviewed	DPH6_HUMAN	Diphthine--ammonia ligase (EC 6.3.1.14) (ATP-binding domain-containing protein 4) (Diphthamide synthase) (Diphthamide synthetase) (Protein DPH6 homolog)	DPH6 ATPBD4	Homo sapiens (Human)	267	FUNCTION: Amidase that may catalyze the last step of diphthamide biosynthesis using ammonium and ATP (PubMed:23169644). Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity). {ECO:0000250|UniProtKB:Q12429, ECO:0000269|PubMed:23169644}.	MISCELLANEOUS: When transfected in S.cerevisiae, able to restore diphthamide biosynthesis in a strain lacking DPH6. {ECO:0000305|PubMed:23169644}.	protein histidyl modification to diphthamide [GO:0017183]	cytosol [GO:0005829]	ATP binding [GO:0005524]; diphthine-ammonia ligase activity [GO:0017178]	cytosol [GO:0005829]; ATP binding [GO:0005524]; diphthine-ammonia ligase activity [GO:0017178]; protein histidyl modification to diphthamide [GO:0017183]	
Q7L9B9	reviewed	EEPD1_HUMAN	Endonuclease/exonuclease/phosphatase family domain-containing protein 1	EEPD1 KIAA1706	Homo sapiens (Human)	569			DNA repair [GO:0006281]; positive regulation of cholesterol efflux [GO:0010875]	plasma membrane [GO:0005886]	DNA binding [GO:0003677]	plasma membrane [GO:0005886]; DNA binding [GO:0003677]; DNA repair [GO:0006281]; positive regulation of cholesterol efflux [GO:0010875]	
Q7LDI9	reviewed	GAK6_HUMAN	Endogenous retrovirus group K member 6 Gag polyprotein (HERV-K(C7) Gag protein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K_7p22.1 provirus ancestral Gag polyprotein) (Gag polyprotein)	ERVK-6 ERVK6	Homo sapiens (Human)	666	FUNCTION: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.		viral process [GO:0016032]	plasma membrane [GO:0005886]	nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]; nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.
Q7M4L6	reviewed	SHF_HUMAN	SH2 domain-containing adapter protein F	SHF	Homo sapiens (Human)	423	FUNCTION: Adapter protein which may play a role in the regulation of apoptosis in response to PDGF. {ECO:0000269|PubMed:11095946}.	MISCELLANEOUS: The sequence described in PubMed:11095946 is over-extended by 57 aa at the N-terminus due to the presence of an uncorrected 5' mismatch compared to the reference genome sequence.	apoptotic process [GO:0006915]		phosphotyrosine residue binding [GO:0001784]	phosphotyrosine residue binding [GO:0001784]; apoptotic process [GO:0006915]	
Q7RTM1	reviewed	OTOP1_HUMAN	Proton channel OTOP1 (Otopetrin-1) (hOtop1)	OTOP1	Homo sapiens (Human)	612	FUNCTION: Proton-selective channel that specifically transports protons into cells (PubMed:29371428). Proton channel activity is only weakly-sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (PubMed:29371428). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for formation of otoconia (By similarity). Regulates purinergic control of intracellular calcium in vestibular supporting cells (By similarity). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (By similarity). Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction (By similarity). {ECO:0000250|UniProtKB:Q80VM9, ECO:0000269|PubMed:29371428}.		biomineral tissue development [GO:0031214]; cellular response to insulin stimulus [GO:0032869]; detection of gravity [GO:0009590]; inner ear morphogenesis [GO:0042472]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; proton transmembrane transport [GO:1902600]	plasma membrane [GO:0005886]	proton channel activity [GO:0015252]	plasma membrane [GO:0005886]; proton channel activity [GO:0015252]; biomineral tissue development [GO:0031214]; cellular response to insulin stimulus [GO:0032869]; detection of gravity [GO:0009590]; inner ear morphogenesis [GO:0042472]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; proton transmembrane transport [GO:1902600]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80VM9}; Multi-pass membrane protein {ECO:0000255}. Note=Detected in the gelatinous membrane overlying the inner ear macular epithelium. {ECO:0000250|UniProtKB:Q80VM9}.
Q7RTR8	reviewed	T2R42_HUMAN	Taste receptor type 2 member 42 (T2R42) (Taste receptor type 2 member 55) (T2R55)	TAS2R42 TAS2R55	Homo sapiens (Human)	314	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	sensory perception of taste [GO:0050909]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; sensory perception of taste [GO:0050909]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q7RTS5	reviewed	OTOP3_HUMAN	Proton channel OTOP3 (Otopetrin-3)	OTOP3	Homo sapiens (Human)	596	FUNCTION: Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. {ECO:0000250|UniProtKB:Q80UF9}.		proton transmembrane transport [GO:1902600]	plasma membrane [GO:0005886]	proton channel activity [GO:0015252]	plasma membrane [GO:0005886]; proton channel activity [GO:0015252]; proton transmembrane transport [GO:1902600]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80VM9}; Multi-pass membrane protein {ECO:0000255}.
Q7RTU9	reviewed	STRC_HUMAN	Stereocilin	STRC	Homo sapiens (Human)	1775	FUNCTION: Essential to the formation of horizontal top connectors between outer hair cell stereocilia. {ECO:0000250}.		auditory receptor cell stereocilium organization [GO:0060088]; cell-matrix adhesion [GO:0007160]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]	cell surface [GO:0009986]; kinocilium [GO:0060091]; stereocilium tip [GO:0032426]		cell surface [GO:0009986]; kinocilium [GO:0060091]; stereocilium tip [GO:0032426]; auditory receptor cell stereocilium organization [GO:0060088]; cell-matrix adhesion [GO:0007160]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]	SUBCELLULAR LOCATION: Cell surface {ECO:0000250}. Cell projection, kinocilium {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}.
Q7RTV2	reviewed	GSTA5_HUMAN	Glutathione S-transferase A5 (EC 2.5.1.18) (GST class-alpha member 5) (Glutathione S-transferase A5-5)	GSTA5	Homo sapiens (Human)	222			glutathione metabolic process [GO:0006749]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	glutathione transferase activity [GO:0004364]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutathione transferase activity [GO:0004364]; glutathione metabolic process [GO:0006749]; xenobiotic metabolic process [GO:0006805]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q7RTV3	reviewed	ZN367_HUMAN	Zinc finger protein 367 (C2H2 zinc finger protein ZFF29)	ZNF367 ZFF29	Homo sapiens (Human)	350	FUNCTION: Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. {ECO:0000269|PubMed:15344908}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15344908}.
Q7RTY5	reviewed	PRS48_HUMAN	Serine protease 48 (EC 3.4.21.-) (Epidermis-specific serine protease-like protein)	PRSS48 ESSPL	Homo sapiens (Human)	328			proteolysis [GO:0006508]	extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]	extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q7RTY7	reviewed	OVCH1_HUMAN	Ovochymase-1 (EC 3.4.21.-)	OVCH1	Homo sapiens (Human)	1134			proteolysis [GO:0006508]	extracellular region [GO:0005576]	metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q7RTY8	reviewed	TMPS7_HUMAN	Transmembrane protease serine 7 (EC 3.4.21.-) (Matriptase-3)	TMPRSS7	Homo sapiens (Human)	843	FUNCTION: Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position. {ECO:0000250}.		proteolysis [GO:0006508]	plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q7RTY9	reviewed	PRS41_HUMAN	Serine protease 41 (EC 3.4.21.-) (Testis serine protease 1) (TESSP-1)	PRSS41 TESSP1	Homo sapiens (Human)	318			proteolysis [GO:0006508]	extracellular region [GO:0005576]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized in the plasma membrane of spermatogonia. Localized in intracellular compartment in spermatocytes, probably in the Golgi apparatus (By similarity). {ECO:0000250}.
Q7RTZ2	reviewed	U17L1_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 1 (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 1) (Ubiquitin thioesterase 17-like protein 1) (Ubiquitin-specific-processing protease 17-like protein 1)	USP17L1 USP17L USP17L1P	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		apoptotic process [GO:0006915]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; apoptotic process [GO:0006915]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Q7Z2G1	reviewed	H2BWT_HUMAN	Histone H2B type W-T (H2B histone family member W testis-specific) (H2B.W histone 1)	H2BW1 H2BFWT	Homo sapiens (Human)	175	FUNCTION: Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function. {ECO:0000269|PubMed:16449661}.	MISCELLANEOUS: In contrast to other H2B histones, it does not contain the conserved residue in C-terminus that is the target of monoubiquitination.; MISCELLANEOUS: Ortholog in primates, but not in rodents.		nuclear membrane [GO:0031965]; nucleosome [GO:0000786]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	nuclear membrane [GO:0031965]; nucleosome [GO:0000786]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:15475252}. Chromosome {ECO:0000269|PubMed:15475252}.
Q7Z2K8	reviewed	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth 1 (GRIN1)	GPRIN1 KIAA1893	Homo sapiens (Human)	1008	FUNCTION: May be involved in neurite outgrowth. {ECO:0000250}.		neuron projection development [GO:0031175]	growth cone [GO:0030426]; plasma membrane [GO:0005886]	phosphoprotein binding [GO:0051219]	growth cone [GO:0030426]; plasma membrane [GO:0005886]; phosphoprotein binding [GO:0051219]; neuron projection development [GO:0031175]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Highly enriched in growth cone. {ECO:0000250}.
Q7Z2T5	reviewed	TRM1L_HUMAN	TRMT1-like protein (EC 2.1.1.-)	TRMT1L C1orf25 TRM1L MSTP070	Homo sapiens (Human)	733	FUNCTION: May play a role in motor coordination and exploratory behavior. {ECO:0000250}.		behavior [GO:0007610]; tRNA N2-guanine methylation [GO:0002940]	nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA (guanine-N2-)-methyltransferase activity [GO:0004809]; tRNA binding [GO:0000049]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA (guanine-N2-)-methyltransferase activity [GO:0004809]; tRNA binding [GO:0000049]; behavior [GO:0007610]; tRNA N2-guanine methylation [GO:0002940]	
Q7Z2W9	reviewed	RM21_HUMAN	Large ribosomal subunit protein bL21m (39S ribosomal protein L21, mitochondrial) (L21mt) (MRP-L21)	MRPL21	Homo sapiens (Human)	205			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q7Z340	reviewed	ZN551_HUMAN	Zinc finger protein 551 (Zinc finger protein KOX23)	ZNF551 KOX23	Homo sapiens (Human)	670	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q7Z398	reviewed	ZN550_HUMAN	Zinc finger protein 550	ZNF550	Homo sapiens (Human)	422	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q7Z3D6	reviewed	GLUCM_HUMAN	D-glutamate cyclase, mitochondrial (EC 4.2.1.48)	DGLUCY C14orf159 UNQ2439/PRO5000	Homo sapiens (Human)	616	FUNCTION: D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline. {ECO:0000250|UniProtKB:Q8BH86}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	glutamate metabolic process [GO:0006536]	mitochondrial matrix [GO:0005759]	D-glutamate cyclase activity [GO:0047820]	mitochondrial matrix [GO:0005759]; D-glutamate cyclase activity [GO:0047820]; glutamate metabolic process [GO:0006536]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q8BH86}.
Q7Z3G6	reviewed	PRIC2_HUMAN	Prickle-like protein 2	PRICKLE2	Homo sapiens (Human)	844			Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]	zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; zinc ion binding [GO:0008270]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000305}.
Q7Z3H4	reviewed	SAMD7_HUMAN	Sterile alpha motif domain-containing protein 7 (SAM domain-containing protein 7)	SAMD7	Homo sapiens (Human)	446	FUNCTION: Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes. {ECO:0000250|UniProtKB:Q8C8Y5}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8C8Y5}. Cytoplasm {ECO:0000250|UniProtKB:Q8C8Y5}.
Q7Z3T1	reviewed	OR2W3_HUMAN	Olfactory receptor 2W3 (Olfactory receptor 2W8) (Olfactory receptor OR1-49)	OR2W3 OR2W3P OR2W8P	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q7Z3V4	reviewed	UBE3B_HUMAN	Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B)	UBE3B	Homo sapiens (Human)	1068	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: Major isoform.	protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]		ubiquitin protein ligase activity [GO:0061630]	ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q7Z3Z3	reviewed	PIWL3_HUMAN	Piwi-like protein 3	PIWIL3	Homo sapiens (Human)	882	FUNCTION: May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). {ECO:0000250|UniProtKB:Q9JMB7}.		cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P granule [GO:0043186]	piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P granule [GO:0043186]; piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521]; cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q9JMB7}.
Q7Z408	reviewed	CSMD2_HUMAN	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2)	CSMD2 KIAA1884	Homo sapiens (Human)	3487				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q7Z444	reviewed	RASE_HUMAN	GTPase ERas (E-Ras) (EC 3.6.5.2) (Embryonic stem cell-expressed Ras)	ERAS HRAS2 HRASP	Homo sapiens (Human)	233	FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity). {ECO:0000250}.		Ras protein signal transduction [GO:0007265]	plasma membrane [GO:0005886]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; Ras protein signal transduction [GO:0007265]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Q7Z4G4	reviewed	TRM11_HUMAN	tRNA (guanine(10)-N2)-methyltransferase homolog (EC 2.1.1.-) (tRNA guanosine-2'-O-methyltransferase TRM11 homolog)	TRMT11 C6orf75 MDS024	Homo sapiens (Human)	463	FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. {ECO:0000250}.			cytoplasm [GO:0005737]	tRNA (guanine-N2-)-methyltransferase activity [GO:0004809]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; tRNA (guanine-N2-)-methyltransferase activity [GO:0004809]; tRNA binding [GO:0000049]	
Q7Z4H3	reviewed	HDDC2_HUMAN	5'-deoxynucleotidase HDDC2 (EC 3.1.3.89) (HD domain-containing protein 2) (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2)	HDDC2 C6orf74 NS5ATP2 CGI-130	Homo sapiens (Human)	204	FUNCTION: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP). {ECO:0000250|UniProtKB:P53144}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.			5'-deoxynucleotidase activity [GO:0002953]; metal ion binding [GO:0046872]	5'-deoxynucleotidase activity [GO:0002953]; metal ion binding [GO:0046872]	
Q7Z4J2	reviewed	GL6D1_HUMAN	Putative glycosyltransferase 6 domain-containing protein 1 (EC 2.4.1.-) (Galactosyltransferase family 6 domain-containing 1)	GLT6D1 GLTDC1 GT6M7	Homo sapiens (Human)	276			carbohydrate metabolic process [GO:0005975]; lipid glycosylation [GO:0030259]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; vesicle [GO:0031982]	glycosyltransferase activity [GO:0016757]; hexosyltransferase activity [GO:0016758]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; vesicle [GO:0031982]; glycosyltransferase activity [GO:0016757]; hexosyltransferase activity [GO:0016758]; carbohydrate metabolic process [GO:0005975]; lipid glycosylation [GO:0030259]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q7Z4Q2	reviewed	HEAT3_HUMAN	HEAT repeat-containing protein 3	HEATR3	Homo sapiens (Human)	680	FUNCTION: Plays a role in ribosome biogenesis and in nuclear import of the 60S ribosomal protein L5/large ribosomal subunit protein uL18 (RPL5) (PubMed:35213692). Required for proper erythrocyte maturation (PubMed:35213692). {ECO:0000269|PubMed:35213692}.		erythrocyte maturation [GO:0043249]; protein import into nucleus [GO:0006606]; ribosomal large subunit biogenesis [GO:0042273]		unfolded protein binding [GO:0051082]	unfolded protein binding [GO:0051082]; erythrocyte maturation [GO:0043249]; protein import into nucleus [GO:0006606]; ribosomal large subunit biogenesis [GO:0042273]	
Q7Z4W2	reviewed	LYZL2_HUMAN	Lysozyme-like protein 2 (Lysozyme-2) (EC 3.2.1.17)	LYZL2	Homo sapiens (Human)	148			metabolic process [GO:0008152]	extracellular region [GO:0005576]	lysozyme activity [GO:0003796]	extracellular region [GO:0005576]; lysozyme activity [GO:0003796]; metabolic process [GO:0008152]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q7Z553	reviewed	MDGA2_HUMAN	MAM domain-containing glycosylphosphatidylinositol anchor protein 2 (MAM domain-containing protein 1)	MDGA2 MAMDC1 UNQ8188/PRO23197	Homo sapiens (Human)	956	FUNCTION: May be involved in cell-cell interactions. {ECO:0000250}.		nervous system development [GO:0007399]; spinal cord motor neuron differentiation [GO:0021522]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; nervous system development [GO:0007399]; spinal cord motor neuron differentiation [GO:0021522]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Q7Z5A4	reviewed	PRS42_HUMAN	Putative serine protease 42 (EC 3.4.21.-) (Serine protease 42, pseudogene) (Testis serine protease 2)	PRSS42P PRSS42 TESSP2	Homo sapiens (Human)	293	FUNCTION: Plays a role in spermatogenesis. Involved in germ cell survival during meiosis. {ECO:0000250|UniProtKB:Q8VIF2}.		cell differentiation [GO:0030154]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	serine-type endopeptidase activity [GO:0004252]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; serine-type endopeptidase activity [GO:0004252]; cell differentiation [GO:0030154]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8VIF2}. Cell membrane {ECO:0000250|UniProtKB:Q8VIF2}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q8VIF2}.
Q7Z5H4	reviewed	VN1R5_HUMAN	Vomeronasal type-1 receptor 5 (G-protein coupled receptor GPCR26) (hGPCR26) (V1r-like receptor 5)	VN1R5 V1RL5	Homo sapiens (Human)	357	FUNCTION: Putative pheromone receptor.	MISCELLANEOUS: The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.	response to pheromone [GO:0019236]	plasma membrane [GO:0005886]	pheromone receptor activity [GO:0016503]	plasma membrane [GO:0005886]; pheromone receptor activity [GO:0016503]; response to pheromone [GO:0019236]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q7Z5H5	reviewed	VN1R4_HUMAN	Vomeronasal type-1 receptor 4 (G-protein coupled receptor GPCR27) (hGPCR27) (V1r-like receptor 4)	VN1R4 V1RL4	Homo sapiens (Human)	301	FUNCTION: Putative pheromone receptor.	MISCELLANEOUS: The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes.	response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606]	plasma membrane [GO:0005886]	pheromone receptor activity [GO:0016503]	plasma membrane [GO:0005886]; pheromone receptor activity [GO:0016503]; response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q7Z5M8	reviewed	AB12B_HUMAN	Protein ABHD12B (EC 3.-.-.-) (Abhydrolase domain-containing protein 12B) (Alpha/beta hydrolase domain-containing protein 12B)	ABHD12B C14orf29	Homo sapiens (Human)	362		MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]	endoplasmic reticulum membrane [GO:0005789]	acylglycerol lipase activity [GO:0047372]; lysophospholipase activity [GO:0004622]	endoplasmic reticulum membrane [GO:0005789]; acylglycerol lipase activity [GO:0047372]; lysophospholipase activity [GO:0004622]; monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]	
Q7Z601	reviewed	GP142_HUMAN	Probable G-protein coupled receptor 142 (G-protein coupled receptor PGR2)	GPR142 PGR2	Homo sapiens (Human)	462	FUNCTION: Orphan receptor.		G protein-coupled receptor signaling pathway [GO:0007186]	cell junction [GO:0030054]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	cell junction [GO:0030054]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q7Z692	reviewed	CEA19_HUMAN	Carcinoembryonic antigen-related cell adhesion molecule 19 (Carcinoembryonic antigen-like 1)	CEACAM19 CEAL1 UNQ2973/PRO7436	Homo sapiens (Human)	300			heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]	cell surface [GO:0009986]; membrane [GO:0016020]		cell surface [GO:0009986]; membrane [GO:0016020]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q7Z695	reviewed	ADCK2_HUMAN	Uncharacterized aarF domain-containing protein kinase 2 (EC 2.7.11.-)	ADCK2 AARF	Homo sapiens (Human)	626	FUNCTION: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).		phosphorylation [GO:0016310]	membrane [GO:0016020]	ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]	membrane [GO:0016020]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q7Z6J2	reviewed	GRASP_HUMAN	Protein TAMALIN (General receptor for phosphoinositides 1-associated scaffold protein) (GRP1-associated scaffold protein)	TAMALIN GRASP	Homo sapiens (Human)	395	FUNCTION: Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. {ECO:0000250}.		regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0099152]; signal transduction [GO:0007165]	glutamatergic synapse [GO:0098978]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; Schaffer collateral - CA1 synapse [GO:0098685]	identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; small GTPase binding [GO:0031267]	glutamatergic synapse [GO:0098978]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; Schaffer collateral - CA1 synapse [GO:0098685]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; small GTPase binding [GO:0031267]; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0099152]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8R4T5}. Cell membrane {ECO:0000250|UniProtKB:Q8R4T5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R4T5}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R4T5}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q8R4T5}.
Q7Z6K4	reviewed	NRARP_HUMAN	Notch-regulated ankyrin repeat-containing protein	NRARP	Homo sapiens (Human)	114	FUNCTION: Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and down-regulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity). {ECO:0000250|UniProtKB:Q91ZA8, ECO:0000269|PubMed:19154719, ECO:0000269|PubMed:25985737, ECO:0000305|PubMed:25985737}.		blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; branching involved in blood vessel morphogenesis [GO:0001569]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of Notch signaling pathway involved in somitogenesis [GO:1902367]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; somite rostral/caudal axis specification [GO:0032525]; T cell differentiation [GO:0030217]; vascular endothelial cell proliferation [GO:0101023]			blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; branching involved in blood vessel morphogenesis [GO:0001569]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of Notch signaling pathway involved in somitogenesis [GO:1902367]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; somite rostral/caudal axis specification [GO:0032525]; T cell differentiation [GO:0030217]; vascular endothelial cell proliferation [GO:0101023]	
Q7Z6Z6	reviewed	PLPL5_HUMAN	Patatin-like phospholipase domain-containing protein 5 (EC 3.1.1.3) (GS2-like protein)	PNPLA5 GS2L	Homo sapiens (Human)	429	FUNCTION: Has abundant triacylglycerol lipase activity. {ECO:0000269|PubMed:16150821}.		lipid homeostasis [GO:0055088]; triglyceride catabolic process [GO:0019433]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]	triglyceride lipase activity [GO:0004806]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; triglyceride lipase activity [GO:0004806]; lipid homeostasis [GO:0055088]; triglyceride catabolic process [GO:0019433]	
Q7Z745	reviewed	MRO2B_HUMAN	Maestro heat-like repeat-containing protein family member 2B (HEAT repeat-containing protein 7B2) (Sperm PKA-interacting factor) (SPIF)	MROH2B HEATR7B2	Homo sapiens (Human)	1585	FUNCTION: May play a role in the process of sperm capacitation. {ECO:0000250|UniProtKB:Q7M6Y6}.		cell differentiation [GO:0030154]; protein kinase A signaling [GO:0010737]; spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]		acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; cell differentiation [GO:0030154]; protein kinase A signaling [GO:0010737]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7M6Y6}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q7M6Y6}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q7M6Y6}. Note=Colocalizes with PRKACA and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm. {ECO:0000250|UniProtKB:Q7M6Y6}.
Q7Z7A3	reviewed	CTU1_HUMAN	Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cancer-associated gene protein) (Cytoplasmic tRNA adenylyltransferase 1)	CTU1 ATPBD3 NCS6	Homo sapiens (Human)	348	FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03053, ECO:0000269|PubMed:19017811}.		protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble position uridine thiolation [GO:0002143]; tRNA wobble uridine modification [GO:0002098]	cytosol [GO:0005829]; cytosolic tRNA wobble base thiouridylase complex [GO:0002144]	nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]	cytosol [GO:0005829]; cytosolic tRNA wobble base thiouridylase complex [GO:0002144]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]; protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble position uridine thiolation [GO:0002143]; tRNA wobble uridine modification [GO:0002098]	SUBCELLULAR LOCATION: Cytoplasm.
Q7Z7B1	reviewed	PIGW_HUMAN	Phosphatidylinositol-glycan biosynthesis class W protein (PIG-W) (EC 2.3.-.-)	PIGW	Homo sapiens (Human)	504	FUNCTION: Required for the transport of GPI-anchored proteins to the plasma membrane (PubMed:24367057). Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity). {ECO:0000250|UniProtKB:Q7TSN4, ECO:0000269|PubMed:24367057}.		GPI anchor metabolic process [GO:0006505]; preassembly of GPI anchor in ER membrane [GO:0016254]; protein localization to plasma membrane [GO:0072659]	endoplasmic reticulum membrane [GO:0005789]	glucosaminyl-phosphatidylinositol O-acyltransferase activity [GO:0032216]; O-acyltransferase activity [GO:0008374]	endoplasmic reticulum membrane [GO:0005789]; glucosaminyl-phosphatidylinositol O-acyltransferase activity [GO:0032216]; O-acyltransferase activity [GO:0008374]; GPI anchor metabolic process [GO:0006505]; preassembly of GPI anchor in ER membrane [GO:0016254]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7TSN4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7TSN4}.
Q7Z7B7	reviewed	DB132_HUMAN	Beta-defensin 132 (Beta-defensin 32) (BD-32) (DEFB-32) (Defensin HEL-75) (Defensin, beta 132)	DEFB132 DEFB32 UNQ827/PRO1754	Homo sapiens (Human)	95	FUNCTION: Has antibacterial activity. {ECO:0000305}.		defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]	extracellular space [GO:0005615]; sperm head [GO:0061827]		extracellular space [GO:0005615]; sperm head [GO:0061827]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q7Z7F7	reviewed	RM55_HUMAN	Large ribosomal subunit protein mL55 (39S ribosomal protein L55, mitochondrial) (L55mt) (MRP-L55) (Mitochondrial large ribosomal subunit protein bL31m)	MRPL55 UNQ5835/PRO19675	Homo sapiens (Human)	128			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; synapse [GO:0045202]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; synapse [GO:0045202]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q7Z7J5	reviewed	DPPA2_HUMAN	Developmental pluripotency-associated protein 2 (Pluripotent embryonic stem cell-related gene 1 protein)	DPPA2 PESCRG1	Homo sapiens (Human)	298	FUNCTION: Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes. {ECO:0000250}.		system development [GO:0048731]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; system development [GO:0048731]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15583978}.
Q7Z7J7	reviewed	LHPL4_HUMAN	LHFPL tetraspan subfamily member 4 protein (GABAA receptor regulatory Lhfpl4) (Lipoma HMGIC fusion partner-like 4 protein)	LHFPL4 GARLH4	Homo sapiens (Human)	247	FUNCTION: Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. {ECO:0000250|UniProtKB:Q5U4E0}.		gamma-aminobutyric acid receptor clustering [GO:0097112]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; regulation of inhibitory synapse assembly [GO:1905702]; sensory perception of sound [GO:0007605]	dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]	GABA receptor binding [GO:0050811]	dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]; GABA receptor binding [GO:0050811]; gamma-aminobutyric acid receptor clustering [GO:0097112]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; regulation of inhibitory synapse assembly [GO:1905702]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TSY2}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q5U4E0}; Multi-pass membrane protein {ECO:0000255}. Note=Specifically localizes to inhibitory postsynaptic sites (By similarity). Colocalizes with GPHN, GABRG2 and NLGN2 at inhibitory postsynaptic sites (By similarity). {ECO:0000250|UniProtKB:Q5U4E0, ECO:0000250|UniProtKB:Q7TSY2}.
Q7Z7L9	reviewed	ZSCA2_HUMAN	Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854)	ZSCAN2 ZFP29 ZNF854	Homo sapiens (Human)	614	FUNCTION: May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q7Z7M1	reviewed	AGRD2_HUMAN	Adhesion G-protein coupled receptor D2 (G-protein coupled receptor 144) (G-protein coupled receptor PGR24)	ADGRD2 GPR144 PGR24	Homo sapiens (Human)	963	FUNCTION: Orphan receptor.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q86SG7	reviewed	LYG2_HUMAN	Lysozyme g-like protein 2 (EC 3.2.1.-)	LYG2 LYGH	Homo sapiens (Human)	212	FUNCTION: May act as a potent antibacterial protein that may play a role in the innate immunity. {ECO:0000269|PubMed:21093056}.		defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; peptidoglycan catabolic process [GO:0009253]	extracellular region [GO:0005576]	lysozyme activity [GO:0003796]	extracellular region [GO:0005576]; lysozyme activity [GO:0003796]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; peptidoglycan catabolic process [GO:0009253]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86SH2	reviewed	ZAR1_HUMAN	Zygote arrest protein 1	ZAR1	Homo sapiens (Human)	424	FUNCTION: mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth. Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs. Binds to the 3'-UTR of maternal mRNAs. Maternal mRNAs stored in the MARDO are translationally repressed. Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation. {ECO:0000250|UniProtKB:Q80SU3}.		mRNA stabilization [GO:0048255]; negative regulation of translation [GO:0017148]; non-membrane-bounded organelle assembly [GO:0140694]; oocyte maturation [GO:0001556]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; intracellular non-membrane-bounded organelle [GO:0043232]	metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; RNA sequestering activity [GO:0140610]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; intracellular non-membrane-bounded organelle [GO:0043232]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; RNA sequestering activity [GO:0140610]; mRNA stabilization [GO:0048255]; negative regulation of translation [GO:0017148]; non-membrane-bounded organelle assembly [GO:0140694]; oocyte maturation [GO:0001556]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q80SU3}. Cytoplasm {ECO:0000250|UniProtKB:Q80SU3}. Note=Specifically localizes to MARDO (mitochondria-associated ribonucleoprotein domain), a mitochondria-associated membraneless compartment that stores mRNAs in oocytes. {ECO:0000250|UniProtKB:Q80SU3}.
Q86SP6	reviewed	GP149_HUMAN	Probable G-protein coupled receptor 149 (G-protein coupled receptor PGR10)	GPR149 PGR10	Homo sapiens (Human)	731	FUNCTION: Orphan receptor.		antral ovarian follicle growth [GO:0001547]; negative regulation of ovulation [GO:0060280]; neuropeptide signaling pathway [GO:0007218]; preantral ovarian follicle growth [GO:0001546]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; antral ovarian follicle growth [GO:0001547]; negative regulation of ovulation [GO:0060280]; neuropeptide signaling pathway [GO:0007218]; preantral ovarian follicle growth [GO:0001546]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q86SX3	reviewed	TEDC1_HUMAN	Tubulin epsilon and delta complex protein 1	TEDC1 C14orf80	Homo sapiens (Human)	495	FUNCTION: Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability (By similarity). May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F (PubMed:28796488). {ECO:0000250|UniProtKB:Q3UK37, ECO:0000269|PubMed:28796488}.		positive regulation of smoothened signaling pathway [GO:0045880]	centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737]		centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737]; positive regulation of smoothened signaling pathway [GO:0045880]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q3UK37}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q3UK37}.
Q86TA1	reviewed	MOB3B_HUMAN	MOB kinase activator 3B (Mob1 homolog 2b) (Mps one binder kinase activator-like 2B) (MOB kinase activator-like 2B)	MOB3B C9orf35 MOBKL2B	Homo sapiens (Human)	216	FUNCTION: Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. {ECO:0000269|PubMed:28792927}.		positive regulation of protein phosphorylation [GO:0001934]; regulation of hippo signaling [GO:0035330]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; positive regulation of protein phosphorylation [GO:0001934]; regulation of hippo signaling [GO:0035330]; signal transduction [GO:0007165]	
Q86TD4	reviewed	SRCA_HUMAN	Sarcalumenin	SRL	Homo sapiens (Human)	473				sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]	GTP binding [GO:0005525]	sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; GTP binding [GO:0005525]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P13666}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P13666}; Peripheral membrane protein {ECO:0000250|UniProtKB:P13666}. Note=May associate with the sarcoplasmic reticulum membrane, via a calcium-dependent mechanism. {ECO:0000250|UniProtKB:P13666}.
Q86TJ5	reviewed	ZN554_HUMAN	Zinc finger protein 554	ZNF554	Homo sapiens (Human)	538	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86TN4	reviewed	TRPT1_HUMAN	tRNA 2'-phosphotransferase 1 (EC 2.7.1.160)	TRPT1	Homo sapiens (Human)	253	FUNCTION: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. {ECO:0000305|PubMed:14504659}.		tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]		tRNA 2'-phosphotransferase activity [GO:0000215]	tRNA 2'-phosphotransferase activity [GO:0000215]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	
Q86U38	reviewed	NOP9_HUMAN	Nucleolar protein 9	NOP9 C14orf21 KIAA2021	Homo sapiens (Human)	636			endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; ribosomal small subunit export from nucleus [GO:0000056]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]; preribosome, small subunit precursor [GO:0030688]	RNA binding [GO:0003723]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]; preribosome, small subunit precursor [GO:0030688]; RNA binding [GO:0003723]; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; ribosomal small subunit export from nucleus [GO:0000056]	
Q86UA1	reviewed	PRP39_HUMAN	Pre-mRNA-processing factor 39 (PRP39 homolog)	PRPF39	Homo sapiens (Human)	669	FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.		mRNA 5'-splice site recognition [GO:0000395]	commitment complex [GO:0000243]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]		commitment complex [GO:0000243]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]; mRNA 5'-splice site recognition [GO:0000395]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q86UB2	reviewed	BIVM_HUMAN	Basic immunoglobulin-like variable motif-containing protein	BIVM	Homo sapiens (Human)	503				cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12036287}. Nucleus {ECO:0000269|PubMed:12036287}.
Q86UB9	reviewed	TM135_HUMAN	Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52)	TMEM135	Homo sapiens (Human)	458	FUNCTION: Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization. {ECO:0000250|UniProtKB:Q5U4F4, ECO:0000250|UniProtKB:Q9CYV5}.		mitochondrion morphogenesis [GO:0070584]; peroxisome organization [GO:0007031]; regulation of mitochondrial fission [GO:0090140]; regulation of oxidative phosphorylation [GO:0002082]; response to cold [GO:0009409]; response to food [GO:0032094]; retinal pigment epithelium development [GO:0003406]	lipid droplet [GO:0005811]; mitochondrial membrane [GO:0031966]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]		lipid droplet [GO:0005811]; mitochondrial membrane [GO:0031966]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; mitochondrion morphogenesis [GO:0070584]; peroxisome organization [GO:0007031]; regulation of mitochondrial fission [GO:0090140]; regulation of oxidative phosphorylation [GO:0002082]; response to cold [GO:0009409]; response to food [GO:0032094]; retinal pigment epithelium development [GO:0003406]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q9CYV5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9CYV5}. Peroxisome membrane {ECO:0000250|UniProtKB:Q9CYV5}; Multi-pass membrane protein {ECO:0000255}.
Q86UE3	reviewed	ZN546_HUMAN	Zinc finger protein 546 (Zinc finger protein 49)	ZNF546 ZNF49	Homo sapiens (Human)	836	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86UP8	reviewed	GTD2A_HUMAN	General transcription factor II-I repeat domain-containing protein 2A (GTF2I repeat domain-containing protein 2A) (Transcription factor GTF2IRD2-alpha)	GTF2IRD2 GTF2IRD2A	Homo sapiens (Human)	949				nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	SUBCELLULAR LOCATION: Nucleus.
Q86UW8	reviewed	HPLN4_HUMAN	Hyaluronan and proteoglycan link protein 4 (Brain link protein 2)	HAPLN4 BRAL2 KIAA1926	Homo sapiens (Human)	402	FUNCTION: Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs (By similarity). Contributes to the formation and transmission of inhibitory GABAergic synapses between Purkinje cells and deep cerebellar nuclei neurons (By similarity). {ECO:0000250|UniProtKB:Q80WM4}.		cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; inhibitory synapse assembly [GO:1904862]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]; synaptic transmission, GABAergic [GO:0051932]	extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202]	hyaluronic acid binding [GO:0005540]; structural constituent of synapse-associated extracellular matrix [GO:0150043]	extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202]; hyaluronic acid binding [GO:0005540]; structural constituent of synapse-associated extracellular matrix [GO:0150043]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; inhibitory synapse assembly [GO:1904862]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]; synaptic transmission, GABAergic [GO:0051932]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9ESM3}.
Q86UY8	reviewed	NT5D3_HUMAN	5'-nucleotidase domain-containing protein 3 (EC 3.1.3.-) (GRP94-neighboring nucleotidase)	NT5DC3 GNN TU12B1-TY	Homo sapiens (Human)	548				cytosol [GO:0005829]; receptor complex [GO:0043235]	5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; receptor complex [GO:0043235]; 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]	
Q86V21	reviewed	AACS_HUMAN	Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog)	AACS ACSF1	Homo sapiens (Human)	672	FUNCTION: Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity). {ECO:0000250|UniProtKB:Q9D2R0, ECO:0000250|UniProtKB:Q9JMI1}.		fatty acid metabolic process [GO:0006631]; ketone body biosynthetic process [GO:0046951]; positive regulation of insulin secretion [GO:0032024]	cytosol [GO:0005829]	acetoacetate-CoA ligase activity [GO:0030729]; ATP binding [GO:0005524]	cytosol [GO:0005829]; acetoacetate-CoA ligase activity [GO:0030729]; ATP binding [GO:0005524]; fatty acid metabolic process [GO:0006631]; ketone body biosynthetic process [GO:0046951]; positive regulation of insulin secretion [GO:0032024]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JMI1}.
Q86VI1	reviewed	EX3L1_HUMAN	Exocyst complex component 3-like protein (Protein Jiangli)	EXOC3L1 EXOC3L	Homo sapiens (Human)	746	FUNCTION: As part of the exocyst, may play a role in regulated exocytosis of insulin granules. {ECO:0000250}.		exocyst localization [GO:0051601]; exocytosis [GO:0006887]; peptide hormone secretion [GO:0030072]	exocyst [GO:0000145]; secretory granule [GO:0030141]; transport vesicle [GO:0030133]	SNARE binding [GO:0000149]	exocyst [GO:0000145]; secretory granule [GO:0030141]; transport vesicle [GO:0030133]; SNARE binding [GO:0000149]; exocyst localization [GO:0051601]; exocytosis [GO:0006887]; peptide hormone secretion [GO:0030072]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=Colocalizes with insulin granules. {ECO:0000250}.
Q86VR7	reviewed	VS10L_HUMAN	V-set and immunoglobulin domain-containing protein 10-like (VSIG10-like protein)	VSIG10L	Homo sapiens (Human)	867				membrane [GO:0016020]; nucleoplasm [GO:0005654]		membrane [GO:0016020]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q86VX2	reviewed	COMD7_HUMAN	COMM domain-containing protein 7	COMMD7 C20orf92	Homo sapiens (Human)	200	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cytoplasmic vesicle [GO:0031410]	NF-kappaB binding [GO:0051059]	cytoplasmic vesicle [GO:0031410]; NF-kappaB binding [GO:0051059]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:21778237}.
Q86VZ1	reviewed	P2RY8_HUMAN	P2Y purinoceptor 8 (P2Y8)	P2RY8	Homo sapiens (Human)	359	FUNCTION: Probable receptor for purines coupled to G-proteins.	MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.	phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	plasma membrane [GO:0005886]	G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q86W11	reviewed	ZSC30_HUMAN	Zinc finger and SCAN domain-containing protein 30 (ZNF-WYM) (Zinc finger protein 397 opposite strand) (Zinc finger protein 397OS)	ZSCAN30 ZNF397OS	Homo sapiens (Human)	494	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86W28	reviewed	NALP8_HUMAN	NACHT, LRR and PYD domains-containing protein 8 (Nucleotide-binding oligomerization domain protein 16) (PYRIN and NACHT-containing protein 4)	NLRP8 NALP8 NOD16 PAN4	Homo sapiens (Human)	1048	FUNCTION: Involved in inflammation. {ECO:0000305}.		regulation of inflammatory response [GO:0050727]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; regulation of inflammatory response [GO:0050727]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q86W33	reviewed	TPRA1_HUMAN	Transmembrane protein adipocyte-associated 1 (Integral membrane protein GPR175) (Transmembrane protein 227)	TPRA1 GPR175 TMEM227 PP6566	Homo sapiens (Human)	373			embryonic cleavage [GO:0040016]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; negative regulation of mitotic cell cycle phase transition [GO:1901991]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; embryonic cleavage [GO:0040016]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; negative regulation of mitotic cell cycle phase transition [GO:1901991]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q86W67	reviewed	F228A_HUMAN	Protein FAM228A	FAM228A C2orf84	Homo sapiens (Human)	206							
Q86WC6	reviewed	PPR27_HUMAN	Protein phosphatase 1 regulatory subunit 27 (Dysferlin-interacting protein 1) (Toonin)	PPP1R27 DYSFIP1	Homo sapiens (Human)	154	FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.				phosphatase binding [GO:0019902]; protein phosphatase inhibitor activity [GO:0004864]	phosphatase binding [GO:0019902]; protein phosphatase inhibitor activity [GO:0004864]	
Q86WI0	reviewed	LHPL1_HUMAN	LHFPL tetraspan subfamily member 1 protein (Lipoma HMGIC fusion partner-like 1 protein)	LHFPL1 UNQ5824/PRO19643	Homo sapiens (Human)	220				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q86WK7	reviewed	AMGO3_HUMAN	Amphoterin-induced protein 3 (AMIGO-3) (Alivin-3)	AMIGO3 ALI3 KIAA1851 UNQ6084/PRO20089	Homo sapiens (Human)	504	FUNCTION: May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity). {ECO:0000250|UniProtKB:Q80ZD5}.		brain development [GO:0007420]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of neuron projection development [GO:0010977]; positive regulation of synapse assembly [GO:0051965]	membrane [GO:0016020]	protein-containing complex binding [GO:0044877]	membrane [GO:0016020]; protein-containing complex binding [GO:0044877]; brain development [GO:0007420]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of neuron projection development [GO:0010977]; positive regulation of synapse assembly [GO:0051965]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q86WK9	reviewed	PAQR7_HUMAN	Membrane progestin receptor alpha (mPR alpha) (Membrane progesterone P4 receptor alpha) (Membrane progesterone receptor alpha) (Progesterone and adipoQ receptor family member 7) (Progestin and adipoQ receptor family member 7) (Progestin and adipoQ receptor family member VII)	PAQR7 MRPA	Homo sapiens (Human)	346	FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870). {ECO:0000269|PubMed:12601167, ECO:0000269|PubMed:23161870, ECO:0000303|PubMed:23763432}.	MISCELLANEOUS: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). {ECO:0000303|PubMed:23763432}.	oogenesis [GO:0048477]; response to steroid hormone [GO:0048545]	plasma membrane [GO:0005886]	nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]	plasma membrane [GO:0005886]; nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]; oogenesis [GO:0048477]; response to steroid hormone [GO:0048545]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:23763432}; Multi-pass membrane protein {ECO:0000255}.
Q86WN2	reviewed	IFNE_HUMAN	Interferon epsilon (IFN-epsilon) (Interferon epsilon-1)	IFNE IFNE1 UNQ360/PRO655	Homo sapiens (Human)	208	FUNCTION: Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity). {ECO:0000250}.		adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86WS3	reviewed	OOSP2_HUMAN	Oocyte-secreted protein 2 (Placenta-specific 1-like protein) (Protein TMEM122)	OOSP2 PLAC1L TMEM122	Homo sapiens (Human)	158	FUNCTION: Involved in oocyte maturation. {ECO:0000269|PubMed:36042231}.		oocyte maturation [GO:0001556]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; oocyte maturation [GO:0001556]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:36042231}.
Q86WW8	reviewed	COA5_HUMAN	Cytochrome c oxidase assembly factor 5	COA5 C2orf64	Homo sapiens (Human)	74	FUNCTION: Involved in an early step of the mitochondrial complex IV assembly process. {ECO:0000269|PubMed:21457908}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; mitochondrial cytochrome c oxidase assembly [GO:0033617]	
Q86X10	reviewed	RLGPB_HUMAN	Ral GTPase-activating protein subunit beta (p170)	RALGAPB KIAA1219	Homo sapiens (Human)	1494	FUNCTION: Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to a competing acceptor splice site. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Splicing acceptor site is not canonical. {ECO:0000305}.	activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056]		GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982]	GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982]; activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056]	
Q86X19	reviewed	TMM17_HUMAN	Transmembrane protein 17	TMEM17	Homo sapiens (Human)	198	FUNCTION: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250}.		cilium assembly [GO:0060271]; non-motile cilium assembly [GO:1905515]; smoothened signaling pathway [GO:0007224]	ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; MKS complex [GO:0036038]		ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; MKS complex [GO:0036038]; cilium assembly [GO:0060271]; non-motile cilium assembly [GO:1905515]; smoothened signaling pathway [GO:0007224]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the transition zone of primary cilia. {ECO:0000250}.
Q86X27	reviewed	RGPS2_HUMAN	Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2)	RALGPS2	Homo sapiens (Human)	583	FUNCTION: Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}.		Ras protein signal transduction [GO:0007265]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; Ras protein signal transduction [GO:0007265]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Associates with membranes through the PH domain. {ECO:0000250}.
Q86X76	reviewed	NIT1_HUMAN	Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.128) (Nitrilase homolog 1)	NIT1	Homo sapiens (Human)	327	FUNCTION: Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. {ECO:0000250|UniProtKB:Q8VDK1}.	MISCELLANEOUS: According to Rosetta Stone theory, the existence of a fusion protein in one genome predicts that the separate polypeptides expressed in other organisms function in the same cellular or biochemical pathway. In Drosophila melanogaster and Caenorhabditis elegans, NitFhit is a fusion protein composed of a C-terminal Fhit domain and a domain related to plant and bacterial nitrilase.; MISCELLANEOUS: [Isoform 2]: Major isoform.; MISCELLANEOUS: [Isoform 6]: Based on a naturally occurring readthrough transcript which produces a NIT1-DEDD fusion protein. The last 4 amino acids of this isoform (PVSS) are encoded by the last DEDD exon. {ECO:0000305}.	amide catabolic process [GO:0043605]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	deaminated glutathione amidase activity [GO:0110050]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; deaminated glutathione amidase activity [GO:0110050]; amide catabolic process [GO:0043605]	SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000250|UniProtKB:Q8VDK1}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q8VDK1}.
Q86X83	reviewed	COMD2_HUMAN	COMM domain-containing protein 2	COMMD2 HSPC042 My004	Homo sapiens (Human)	199	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.			cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778237}.
Q86XD5	reviewed	F131B_HUMAN	Protein FAM131B	FAM131B KIAA0773	Homo sapiens (Human)	332				cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	
Q86XH1	reviewed	DRC11_HUMAN	Dynein regulatory complex protein 11 (IQ and AAA domain-containing protein 1)	IQCA1 DRC11 IQCA	Homo sapiens (Human)	822	FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. {ECO:0000250|UniProtKB:A8IHT2}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8IHT2}.
Q86XI6	reviewed	PPR3B_HUMAN	Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG)	PPP1R3B PPP1R4	Homo sapiens (Human)	285	FUNCTION: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). {ECO:0000250}.		glycogen metabolic process [GO:0005977]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]	glycogen granule [GO:0042587]; protein phosphatase type 1 complex [GO:0000164]	[phosphorylase] phosphatase activity [GO:0050196]; glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase regulator activity [GO:0019888]	glycogen granule [GO:0042587]; protein phosphatase type 1 complex [GO:0000164]; [phosphorylase] phosphatase activity [GO:0050196]; glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase regulator activity [GO:0019888]; glycogen metabolic process [GO:0005977]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]	
Q86XN7	reviewed	PRSR1_HUMAN	Proline and serine-rich protein 1	PROSER1 C13orf23 KIAA2032	Homo sapiens (Human)	944	FUNCTION: Mediates OGT interaction with and O-GlcNAcylation of TET2 to control TET2 stabilization at enhancers and CpG islands (CGIs). {ECO:0000269|PubMed:34667079}.						
Q86XP6	reviewed	GKN2_HUMAN	Gastrokine-2 (Blottin) (Down-regulated in gastric cancer) (Trefoil factor interactions(z) 1)	GKN2 BLOT GDDR TFIZ1 UNQ465/PRO813	Homo sapiens (Human)	184			regulation of cell population proliferation [GO:0042127]; response to bacterium [GO:0009617]	basal part of cell [GO:0045178]; extracellular space [GO:0005615]		basal part of cell [GO:0045178]; extracellular space [GO:0005615]; regulation of cell population proliferation [GO:0042127]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Secreted.
Q86XR2	reviewed	NIBA3_HUMAN	Protein Niban 3 (B-cell novel protein 1) (Niban-like protein 2) (Protein FAM129C)	NIBAN3 BCNP1 FAM129C	Homo sapiens (Human)	697							
Q86XR5	reviewed	PRIMA_HUMAN	Proline-rich membrane anchor 1 (PRiMA)	PRIMA1	Homo sapiens (Human)	153	FUNCTION: Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	neurotransmitter catabolic process [GO:0042135]	anchoring junction [GO:0070161]; plasma membrane [GO:0005886]; synapse [GO:0045202]		anchoring junction [GO:0070161]; plasma membrane [GO:0005886]; synapse [GO:0045202]; neurotransmitter catabolic process [GO:0042135]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction {ECO:0000250}. Synapse {ECO:0000250}. Note=In the brain, PRIMA linked to ACHE is found in membrane rafts. {ECO:0000250}.
Q86XT9	reviewed	TM219_HUMAN	Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) (Transmembrane protein 219)	TMEM219	Homo sapiens (Human)	240	FUNCTION: Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding. {ECO:0000269|PubMed:20353938}.		apoptotic process [GO:0006915]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; apoptotic process [GO:0006915]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20353938}; Single-pass membrane protein {ECO:0000269|PubMed:20353938}.
Q86XW9	reviewed	TXND6_HUMAN	Thioredoxin domain-containing protein 6 (Thioredoxin-like protein 2) (Txl-2)	NME9 TXL2 TXNDC6	Homo sapiens (Human)	330	FUNCTION: May be a regulator of microtubule physiology. {ECO:0000305|PubMed:12569107}.	MISCELLANEOUS: Shows no detectable enzyme activity.	CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228]	cell projection [GO:0042995]; cytoskeleton [GO:0005856]; dynein axonemal particle [GO:0120293]	nucleoside diphosphate kinase activity [GO:0004550]	cell projection [GO:0042995]; cytoskeleton [GO:0005856]; dynein axonemal particle [GO:0120293]; nucleoside diphosphate kinase activity [GO:0004550]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A0A1L1SUL6}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q6IRC5}. Note=Associated with microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette. {ECO:0000250|UniProtKB:A0A1L1SUL6}.
Q86Y22	reviewed	CONA1_HUMAN	Collagen alpha-1(XXIII) chain	COL23A1	Homo sapiens (Human)	540			extracellular matrix organization [GO:0030198]	basement membrane [GO:0005604]; cell surface [GO:0009986]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]	basement membrane [GO:0005604]; cell surface [GO:0009986]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}.
Q86Y25	reviewed	Z354C_HUMAN	Zinc finger protein 354C (Kidney, ischemia, and developmentally-regulated protein 3) (hKID3)	ZNF354C KID3	Homo sapiens (Human)	554	FUNCTION: May function as a transcription repressor. Binds to 5'-CCACA-3' core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). {ECO:0000250|UniProtKB:Q571J5, ECO:0000250|UniProtKB:Q9EPU7, ECO:0000269|PubMed:15555547}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15555547}.
Q86Y79	reviewed	PTH_HUMAN	Peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29)	PTRH1 C9orf115	Homo sapiens (Human)	214	FUNCTION: Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes (PubMed:30244831). Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes (PubMed:30244831). Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation (PubMed:30244831). {ECO:0000269|PubMed:30244831}.		rescue of stalled ribosome [GO:0072344]		aminoacyl-tRNA hydrolase activity [GO:0004045]; RNA binding [GO:0003723]	aminoacyl-tRNA hydrolase activity [GO:0004045]; RNA binding [GO:0003723]; rescue of stalled ribosome [GO:0072344]	
Q86YE8	reviewed	ZN573_HUMAN	Zinc finger protein 573	ZNF573	Homo sapiens (Human)	665	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86YH2	reviewed	Z280B_HUMAN	Zinc finger protein 280B (5'OY11.1) (Suppressor of hairy wing homolog 2) (Zinc finger protein 279) (Zinc finger protein 632)	ZNF280B SUHW2 ZNF279 ZNF632	Homo sapiens (Human)	543	FUNCTION: May function as a transcription factor.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86YL5	reviewed	TDRP_HUMAN	Testis development-related protein (Protein INM01)	TDRP C8orf42	Homo sapiens (Human)	185	FUNCTION: Contributes to normal sperm motility, but not essential for male fertility. {ECO:0000250|UniProtKB:Q8C5P7}.		spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20170638, ECO:0000269|PubMed:27069551}. Cytoplasm {ECO:0000269|PubMed:20170638, ECO:0000269|PubMed:27069551}. Note=Mainly nuclear. Also detected in cytoplasm near the midpiece of the flagellum. {ECO:0000269|PubMed:27069551}.
Q86YN1	reviewed	DOPP1_HUMAN	Dolichyldiphosphatase 1 (EC 3.6.1.43) (Dolichyl pyrophosphate phosphatase 1)	DOLPP1 LSFR2	Homo sapiens (Human)	238	FUNCTION: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity). {ECO:0000250|UniProtKB:Q9JMF7}.		dolichyl diphosphate biosynthetic process [GO:0006489]; lipid biosynthetic process [GO:0008610]; protein N-linked glycosylation [GO:0006487]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	dolichyldiphosphatase activity [GO:0047874]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; dolichyldiphosphatase activity [GO:0047874]; dolichyl diphosphate biosynthetic process [GO:0006489]; lipid biosynthetic process [GO:0008610]; protein N-linked glycosylation [GO:0006487]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q86YV6	reviewed	MYLK4_HUMAN	Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085)	MYLK4 SGK085	Homo sapiens (Human)	388		MISCELLANEOUS: [Isoform 2]: Sequence incomplete. {ECO:0000305}.	phosphorylation [GO:0016310]		ATP binding [GO:0005524]; myosin light chain kinase activity [GO:0004687]; protein serine kinase activity [GO:0106310]	ATP binding [GO:0005524]; myosin light chain kinase activity [GO:0004687]; protein serine kinase activity [GO:0106310]; phosphorylation [GO:0016310]	
Q8IUC0	reviewed	KR131_HUMAN	Keratin-associated protein 13-1 (High sulfur keratin-associated protein 13.1)	KRTAP13-1 KAP13.1 KRTAP13.1	Homo sapiens (Human)	172	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q8IUE0	reviewed	TF2LY_HUMAN	Homeobox protein TGIF2LY (TGF-beta-induced transcription factor 2-like protein) (TGFB-induced factor 2-like protein, Y-linked) (TGIF-like on the Y)	TGIF2LY TGIFLY	Homo sapiens (Human)	185	FUNCTION: May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.		negative regulation of transcription by RNA polymerase II [GO:0000122]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q8IUE1	reviewed	TF2LX_HUMAN	Homeobox protein TGIF2LX (TGF-beta-induced transcription factor 2-like protein) (TGFB-induced factor 2-like protein, X-linked) (TGIF-like on the X)	TGIF2LX TGIFLX	Homo sapiens (Human)	241	FUNCTION: May have a transcription role in testis.		negative regulation of transcription by RNA polymerase II [GO:0000122]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q8IUR0	reviewed	TPPC5_HUMAN	Trafficking protein particle complex subunit 5	TRAPPC5	Homo sapiens (Human)	188	FUNCTION: May play a role in vesicular transport from endoplasmic reticulum to Golgi.		COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; TRAPP complex [GO:0030008]; TRAPPI protein complex [GO:1990070]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; TRAPP complex [GO:0030008]; TRAPPI protein complex [GO:1990070]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Q8IUZ0	reviewed	LRC49_HUMAN	Leucine-rich repeat-containing protein 49 (Centriolar satellite-associated tubulin polyglutamylase complex regulator 2) (Tubulin polyglutamylase complex subunit 4) (PGs4)	LRRC49 CSTPP2	Homo sapiens (Human)	686	FUNCTION: Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. {ECO:0000305|PubMed:34782749}.			centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; microtubule [GO:0005874]		centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; microtubule [GO:0005874]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:34782749}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:34782749}. Note=Associated with microtubules. {ECO:0000269|PubMed:34782749}.
Q8IV01	reviewed	SYT12_HUMAN	Synaptotagmin-12 (Synaptotagmin XII) (SytXII)	SYT12	Homo sapiens (Human)	421	FUNCTION: Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity). Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids (By similarity). Essential for mossy-fiber long-term potentiation in the hippocampus (By similarity). {ECO:0000250|UniProtKB:P97610, ECO:0000250|UniProtKB:Q920N7}.		calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; long-term synaptic potentiation [GO:0060291]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; spontaneous exocytosis of neurotransmitter [GO:0048792]	exocytic vesicle [GO:0070382]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]	exocytic vesicle [GO:0070382]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; long-term synaptic potentiation [GO:0060291]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; spontaneous exocytosis of neurotransmitter [GO:0048792]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P97610}; Single-pass membrane protein {ECO:0000255}.
Q8IV13	reviewed	CCNJL_HUMAN	Cyclin-J-like protein	CCNJL	Homo sapiens (Human)	435			mitotic cell cycle phase transition [GO:0044772]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; mitotic cell cycle phase transition [GO:0044772]	
Q8IVV2	reviewed	LOXH1_HUMAN	Lipoxygenase homology domain-containing protein 1	LOXHD1	Homo sapiens (Human)	2067	FUNCTION: Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity). {ECO:0000250, ECO:0000269|PubMed:19732867}.		sensory perception of sound [GO:0007605]	stereocilium [GO:0032420]		stereocilium [GO:0032420]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000250}.
Q8IVW1	reviewed	ARL17_HUMAN	ADP-ribosylation factor-like protein 17 (ADP-ribosylation factor 7 variant)	ARL17A ARL17P1; ARL17B ARF1P2 ARL17A PRO2667	Homo sapiens (Human)	177	FUNCTION: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). {ECO:0000250}.		intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	Golgi apparatus [GO:0005794]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi apparatus [GO:0005794]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}.
Q8IW03	reviewed	SIAH3_HUMAN	Seven in absentia homolog 3 (Siah-3)	SIAH3	Homo sapiens (Human)	269	FUNCTION: Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria. {ECO:0000269|PubMed:24270810}.		negative regulation of protein targeting to mitochondrion [GO:1903215]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein stability [GO:0031647]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of protein targeting to mitochondrion [GO:1903215]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:24270810}.
Q8IW36	reviewed	ZN695_HUMAN	Zinc finger protein 695 (Zinc finger protein SBZF3)	ZNF695	Homo sapiens (Human)	515	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IW93	reviewed	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor 19 (Ephexin-2)	ARHGEF19	Homo sapiens (Human)	802	FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. {ECO:0000250}.		regulation of actin cytoskeleton organization [GO:0032956]; regulation of small GTPase mediated signal transduction [GO:0051056]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing [GO:0042060]	cytosol [GO:0005829]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of small GTPase mediated signal transduction [GO:0051056]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing [GO:0042060]	
Q8IWB9	reviewed	TEX2_HUMAN	Testis-expressed protein 2 (Transmembrane protein 96)	TEX2 KIAA1738 TMEM96	Homo sapiens (Human)	1127	FUNCTION: During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}.		lipid transport [GO:0006869]; signal transduction [GO:0007165]; sphingolipid metabolic process [GO:0006665]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]	lipid binding [GO:0008289]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; lipid binding [GO:0008289]; lipid transport [GO:0006869]; signal transduction [GO:0007165]; sphingolipid metabolic process [GO:0006665]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q06833}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:Q06833}; Multi-pass membrane protein {ECO:0000255}. Note=Enriched at the nucleus-vacuole junction (PubMed:22250200). During endoplasmic reticulum (ER) stress, localizes to ER-Golgi contacts (By similarity). {ECO:0000250|UniProtKB:Q06833, ECO:0000269|PubMed:22250200}.
Q8IWF6	reviewed	DEN6A_HUMAN	Protein DENND6A (DENN domain-containing protein 6A)	DENND6A FAM116A	Homo sapiens (Human)	608	FUNCTION: Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes. {ECO:0000269|PubMed:22595670}.		positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; recycling endosome [GO:0055037]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; recycling endosome [GO:0055037]; guanyl-nucleotide exchange factor activity [GO:0005085]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]	SUBCELLULAR LOCATION: Recycling endosome {ECO:0000269|PubMed:22595670}. Cytoplasm {ECO:0000269|PubMed:22595670}.
Q8IWP9	reviewed	CC28A_HUMAN	Coiled-coil domain-containing protein 28A (CCRL1AP)	CCDC28A C6orf80	Homo sapiens (Human)	274							
Q8IWR0	reviewed	Z3H7A_HUMAN	Zinc finger CCCH domain-containing protein 7A	ZC3H7A ZC3H7 ZC3HDC7 HSPC055	Homo sapiens (Human)	971	FUNCTION: May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}.		miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608]	nucleus [GO:0005634]	metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IWY8	reviewed	ZSC29_HUMAN	Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690)	ZSCAN29 ZNF690	Homo sapiens (Human)	852	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IX06	reviewed	GOR_HUMAN	Putative exonuclease GOR (EC 3.1.-.-) (Antigen GOR homolog) (RNA exonuclease 1 homolog-like 1)	REXO1L1P GOR REXO1L1	Homo sapiens (Human)	675				cytoplasm [GO:0005737]; nucleus [GO:0005634]	exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11472404}. Nucleus {ECO:0000305|PubMed:11472404}.
Q8IX18	reviewed	DHX40_HUMAN	Probable ATP-dependent RNA helicase DHX40 (EC 3.6.4.13) (DEAH box protein 40) (Protein PAD)	DHX40 DDX40 ARG147	Homo sapiens (Human)	779	FUNCTION: Probable ATP-dependent RNA helicase. {ECO:0000250}.				ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	
Q8IX29	reviewed	FBX16_HUMAN	F-box only protein 16	FBXO16 FBX16	Homo sapiens (Human)	292	FUNCTION: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.						
Q8IXS8	reviewed	HYCC2_HUMAN	Hyccin 2	HYCC2 FAM126B	Homo sapiens (Human)	530	FUNCTION: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. {ECO:0000305|PubMed:26571211}.		phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	cytosol [GO:0005829]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; plasma membrane [GO:0005886]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BYI3}. Cell membrane {ECO:0000250|UniProtKB:Q9BYI3}.
Q8IXT1	reviewed	DDIAS_HUMAN	DNA damage-induced apoptosis suppressor protein (Nitric oxide-inducible gene protein)	DDIAS C11orf82 NOXIN	Homo sapiens (Human)	998	FUNCTION: May be an anti-apoptotic protein involved in DNA repair or cell survival. {ECO:0000269|PubMed:24214091}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; regulation of cell cycle [GO:0051726]; regulation of DNA stability [GO:0097752]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; regulation of cell cycle [GO:0051726]; regulation of DNA stability [GO:0097752]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Accumulates in the nucleus in response to stress. {ECO:0000250}.
Q8IXT2	reviewed	DMRTD_HUMAN	Doublesex- and mab-3-related transcription factor C2	DMRTC2	Homo sapiens (Human)	367	FUNCTION: May be involved in sexual development. {ECO:0000269|PubMed:11863363}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	heterochromatin organization [GO:0070828]; male meiosis I [GO:0007141]; sex differentiation [GO:0007548]; spermatid nucleus elongation [GO:0007290]	chromatin [GO:0000785]; nucleus [GO:0005634]; XY body [GO:0001741]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; XY body [GO:0001741]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]; heterochromatin organization [GO:0070828]; male meiosis I [GO:0007141]; sex differentiation [GO:0007548]; spermatid nucleus elongation [GO:0007290]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Q8IXY8	reviewed	PPIL6_HUMAN	Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (PPIase) (Cyclophilin-like protein PPIL6) (Rotamase PPIL6)	PPIL6	Homo sapiens (Human)	311	FUNCTION: Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. {ECO:0000269|PubMed:20676357}.		protein folding [GO:0006457]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; protein folding [GO:0006457]	
Q8IXZ3	reviewed	SP8_HUMAN	Transcription factor Sp8 (Specificity protein 8)	SP8	Homo sapiens (Human)	490	FUNCTION: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). {ECO:0000250}.		dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IY47	reviewed	KBTB2_HUMAN	Kelch repeat and BTB domain-containing protein 2 (BTB and kelch domain-containing protein 1)	KBTBD2 BKLHD1 KIAA1489 CGI-73	Homo sapiens (Human)	623	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation. {ECO:0000269|PubMed:27708159}.		gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; protein ubiquitination [GO:0016567]; response to insulin [GO:0032868]			gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; protein ubiquitination [GO:0016567]; response to insulin [GO:0032868]	
Q8IY67	reviewed	RAVR1_HUMAN	Ribonucleoprotein PTB-binding 1 (Protein raver-1)	RAVER1 KIAA1978	Homo sapiens (Human)	606	FUNCTION: Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytoplasm [GO:0005737]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Nuclear, in perinucleolar structures. Shuttles between nucleus and cytoplasm. Cytoplasm, at focal contacts and cell-cell contacts. Associated with myotubes during muscle differentiation (By similarity). {ECO:0000250}.
Q8IYD9	reviewed	LAS2_HUMAN	Lung adenoma susceptibility protein 2	LAS2 C18orf54	Homo sapiens (Human)	372	FUNCTION: Might play a role in cell proliferation. {ECO:0000250}.		negative regulation of cell population proliferation [GO:0008285]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; negative regulation of cell population proliferation [GO:0008285]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8IYK8	reviewed	REM2_HUMAN	GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2)	REM2	Homo sapiens (Human)	340	FUNCTION: Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. {ECO:0000250|UniProtKB:Q9WTY2}.			plasma membrane [GO:0005886]	calcium channel regulator activity [GO:0005246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; calcium channel regulator activity [GO:0005246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9WTY2}.
Q8IYL2	reviewed	TRM44_HUMAN	Probable tRNA (uracil-O(2)-)-methyltransferase (EC 2.1.1.211) (Methyltransferase-like protein 19)	TRMT44 C4orf23 METTL19	Homo sapiens (Human)	757	FUNCTION: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase. {ECO:0000250}.		tRNA methylation [GO:0030488]	cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA (uracil) methyltransferase activity [GO:0016300]; tRNA (uracil-2'-O-)-methyltransferase activity [GO:0052665]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA (uracil) methyltransferase activity [GO:0016300]; tRNA (uracil-2'-O-)-methyltransferase activity [GO:0052665]; tRNA methylation [GO:0030488]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8IYN2	reviewed	TCAL8_HUMAN	Transcription elongation factor A protein-like 8 (TCEA-like protein 8) (Transcription elongation factor S-II protein-like 8)	TCEAL8	Homo sapiens (Human)	117	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IYS0	reviewed	ASTRC_HUMAN	Protein Aster-C (GRAM domain-containing protein 1C)	GRAMD1C UNQ2543/PRO6095	Homo sapiens (Human)	662	FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q8CI52}.		cellular response to cholesterol [GO:0071397]; intracellular sterol transport [GO:0032366]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; cellular response to cholesterol [GO:0071397]; intracellular sterol transport [GO:0032366]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8CI52}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8CI52}; Single-pass membrane protein {ECO:0000255}. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS). {ECO:0000250|UniProtKB:Q8CI52}.
Q8IYS4	reviewed	DAAF8_HUMAN	Dynein axonemal assembly factor 8 (Dynein axonemal-associated protein 1)	DNAAF8 C16orf71 DAAP1	Homo sapiens (Human)	520	FUNCTION: In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits. {ECO:0000250|UniProtKB:A0A1L8EYB2}.		outer dynein arm assembly [GO:0036158]	dynein axonemal particle [GO:0120293]	dynein complex binding [GO:0070840]	dynein axonemal particle [GO:0120293]; dynein complex binding [GO:0070840]; outer dynein arm assembly [GO:0036158]	SUBCELLULAR LOCATION: Dynein axonemal particle {ECO:0000269|PubMed:33263282}.
Q8IYT1	reviewed	GAR4_HUMAN	Golgi-associated RAB2 interactor protein 4 (Golgi-associated Rab2B interactor-like 4) (GARI-L4) (GARI-like 4)	GARIN4 FAM71A	Homo sapiens (Human)	594	FUNCTION: RAB2B effector protein required for the compacted Golgi morphology, probably through interaction with small GTPase RAB2B. {ECO:0000269|PubMed:26209634}.		Golgi organization [GO:0007030]	Golgi apparatus [GO:0005794]; nucleus [GO:0005634]		Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; Golgi organization [GO:0007030]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:26209634}.
Q8IYU4	reviewed	UBQLN_HUMAN	Ubiquilin-like protein	UBQLNL	Homo sapiens (Human)	475			ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]	polyubiquitin modification-dependent protein binding [GO:0031593]	cytosol [GO:0005829]; polyubiquitin modification-dependent protein binding [GO:0031593]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q8IYW2	reviewed	CFA46_HUMAN	Cilia- and flagella-associated protein 46 (Tetratricopeptide repeat protein 40)	CFAP46 C10orf123 C10orf124 C10orf92 C10orf93 TTC40	Homo sapiens (Human)	2715	FUNCTION: As part of the central apparatus of the cilium axoneme plays a role in cilium movement. {ECO:0000250|UniProtKB:A8ICS9}.		axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294]	axoneme [GO:0005930]		axoneme [GO:0005930]; axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A8ICS9}.
Q8IYX0	reviewed	ZN679_HUMAN	Zinc finger protein 679	ZNF679	Homo sapiens (Human)	411	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IYX4	reviewed	DND1_HUMAN	Dead end protein homolog 1 (RNA-binding motif, single-stranded-interacting protein 4)	DND1 RBMS4	Homo sapiens (Human)	353	FUNCTION: RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). {ECO:0000250, ECO:0000269|PubMed:18155131}.		3'-UTR-mediated mRNA destabilization [GO:0061158]; germ cell development [GO:0007281]; mRNA stabilization [GO:0048255]; negative regulation of miRNA-mediated gene silencing [GO:0060965]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; germ cell development [GO:0007281]; mRNA stabilization [GO:0048255]; negative regulation of miRNA-mediated gene silencing [GO:0060965]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18155131}. Cytoplasm {ECO:0000269|PubMed:18155131}. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). {ECO:0000250}.
Q8IZ08	reviewed	GP135_HUMAN	G-protein coupled receptor 135	GPR135	Homo sapiens (Human)	494	FUNCTION: Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). {ECO:0000269|PubMed:28827538}.		G protein-coupled receptor signaling pathway [GO:0007186]	endosome [GO:0005768]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	arrestin family protein binding [GO:1990763]; G protein-coupled receptor activity [GO:0004930]	endosome [GO:0005768]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; arrestin family protein binding [GO:1990763]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with ARRB2/beta-arrestin-2 in the endosome. {ECO:0000269|PubMed:28827538}.
Q8IZ26	reviewed	ZNF34_HUMAN	Zinc finger protein 34 (Zinc finger protein KOX32)	ZNF34 KOX32	Homo sapiens (Human)	560	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IZ57	reviewed	NRSN1_HUMAN	Neurensin-1 (Neuro-p24) (Vesicular membrane protein of 24 kDa) (Vesicular membrane protein p24)	NRSN1 VMP	Homo sapiens (Human)	195	FUNCTION: May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory consolidation (By similarity). {ECO:0000250|UniProtKB:P97799, ECO:0000269|PubMed:12463420}.		nervous system development [GO:0007399]	cytoplasmic vesicle [GO:0031410]; growth cone [GO:0030426]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; transport vesicle [GO:0030133]		cytoplasmic vesicle [GO:0031410]; growth cone [GO:0030426]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; transport vesicle [GO:0030133]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P97799}.
Q8IZ73	reviewed	RUSD2_HUMAN	Pseudouridylate synthase RPUSD2 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 2)	RPUSD2 C15orf19	Homo sapiens (Human)	545	FUNCTION: Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. {ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:35051350}.		enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]		pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]	pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]	
Q8IZ83	reviewed	A16A1_HUMAN	Aldehyde dehydrogenase family 16 member A1	ALDH16A1	Homo sapiens (Human)	802				membrane [GO:0016020]	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]	membrane [GO:0016020]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]	
Q8IZA3	reviewed	H18_HUMAN	Histone H1.8 (Histone H1oo) (Oocyte-specific histone H1) (Oocyte-specific linker histone H1) (osH1)	H1-8 H1FOO H1OO OSH1	Homo sapiens (Human)	346	FUNCTION: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). {ECO:0000250}.		chromosome condensation [GO:0030261]; epigenetic regulation of gene expression [GO:0040029]; meiotic cell cycle [GO:0051321]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]	double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; structural constituent of chromatin [GO:0030527]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; structural constituent of chromatin [GO:0030527]; chromosome condensation [GO:0030261]; epigenetic regulation of gene expression [GO:0040029]; meiotic cell cycle [GO:0051321]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837}.
Q8IZF4	reviewed	AGRG5_HUMAN	Adhesion G-protein coupled receptor G5 (G-protein coupled receptor 114) (G-protein coupled receptor PGR27)	ADGRG5 GPR114 PGR27 UNQ2524/PRO6017	Homo sapiens (Human)	528	FUNCTION: Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). {ECO:0000250|UniProtKB:Q3V3Z3, ECO:0000305|PubMed:25713288}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3V3Z3}; Multi-pass membrane protein {ECO:0000305|PubMed:25713288}.
Q8IZF5	reviewed	AGRF3_HUMAN	Adhesion G-protein coupled receptor F3 (G-protein coupled receptor 113) (G-protein coupled receptor PGR23)	ADGRF3 GPR113 PGR23 UNQ9196/PRO34000	Homo sapiens (Human)	1079	FUNCTION: Orphan receptor.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q8IZJ0	reviewed	IFNL2_HUMAN	Interferon lambda-2 (IFN-lambda-2) (Cytokine Zcyto20) (Interleukin-28A) (IL-28A)	IFNL2 IL28A ZCYTO20	Homo sapiens (Human)	200	FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210, ECO:0000269|PubMed:16539846}.		cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; mucosal immune response [GO:0002385]; positive regulation of immune response [GO:0050778]; receptor signaling pathway via JAK-STAT [GO:0007259]; type III interferon-mediated signaling pathway [GO:0038196]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; mucosal immune response [GO:0002385]; positive regulation of immune response [GO:0050778]; receptor signaling pathway via JAK-STAT [GO:0007259]; type III interferon-mediated signaling pathway [GO:0038196]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12483210}.
Q8IZJ4	reviewed	RGDSR_HUMAN	Ral-GDS-related protein (hRGR) (Ral guanine nucleotide dissociation stimulator-like 4) (RalGDS-like 4)	RGL4 RGR	Homo sapiens (Human)	473			Ras protein signal transduction [GO:0007265]	cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; Ras protein signal transduction [GO:0007265]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}.
Q8IZM9	reviewed	S38A6_HUMAN	Solute carrier family 38 member 6 (Amino acid transporter SLC38A6) (N-system amino acid transporter 1) (NAT-1)	SLC38A6 NAT1 SNAT6	Homo sapiens (Human)	456	FUNCTION: Amino acid transporter with an apparent selectivity for L-glutamine and L-glutamate. May facilitate glutamine uptake in excitatory neurons. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:G3UVW3}.		amino acid transmembrane transport [GO:0003333]; glutamine transport [GO:0006868]; sodium ion transport [GO:0006814]	plasma membrane [GO:0005886]	L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamine transmembrane transporter activity [GO:0015186]	plasma membrane [GO:0005886]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamine transmembrane transporter activity [GO:0015186]; amino acid transmembrane transport [GO:0003333]; glutamine transport [GO:0006868]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:G3UVW3}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:G3UVW3}. Note=Colocalizes with synaptotagmins and SNAP25. {ECO:0000250|UniProtKB:G3UVW3}.
Q8IZP7	reviewed	H6ST3_HUMAN	Heparan-sulfate 6-O-sulfotransferase 3 (HS6ST-3) (EC 2.8.2.-)	HS6ST3	Homo sapiens (Human)	471	FUNCTION: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.		heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	heparan sulfate 6-O-sulfotransferase activity [GO:0017095]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; heparan sulfate 6-O-sulfotransferase activity [GO:0017095]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8IZS5	reviewed	OFCC1_HUMAN	Orofacial cleft 1 candidate gene 1 protein (Orofacial clefting chromosomal breakpoint region candidate 1 protein)	OFCC1 MRDS1	Homo sapiens (Human)	231							
Q8IZS6	reviewed	DYLT2_HUMAN	Dynein light chain Tctex-type protein 2 (T-complex testis-specific protein 3) (T-complex-associated testis-expressed protein 3) (Tcte-3) (Tctex1 domain-containing protein 3)	DYNLT2 TCTE3 TCTEX1D3	Homo sapiens (Human)	198	FUNCTION: May be an accessory component of axonemal dynein and cytoplasmic dynein 1 (PubMed:11278908, PubMed:12584439). Candidate for involvement in male sterility (By similarity). {ECO:0000250|UniProtKB:P11985, ECO:0000269|PubMed:11278908, ECO:0000269|PubMed:12584439}.		microtubule-based movement [GO:0007018]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; membrane [GO:0016020]; microtubule [GO:0005874]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; membrane [GO:0016020]; microtubule [GO:0005874]; dynein intermediate chain binding [GO:0045505]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P11985}. Cytoplasmic granule {ECO:0000250|UniProtKB:P11985}. Membrane {ECO:0000250|UniProtKB:P11985}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11985}. Note=Found on the surface of sperm tail. Stored in cytoplasmic granules during spermatogenesis. {ECO:0000250|UniProtKB:P11985}.
Q8IZS7	reviewed	CLCL1_HUMAN	Putative C-type lectin-like domain family 1 (C-type lectin-like domain family 1 pseudogene) (Dendritic cell-associated lectin 1) (DC-associated lectin-1) (DCAL-1)	CLECL1P CLECL1 DCAL1	Homo sapiens (Human)	167	FUNCTION: May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response. {ECO:0000269|PubMed:12421943}.		B cell adhesion [GO:0097323]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of T cell proliferation [GO:0042102]	plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]	plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; B cell adhesion [GO:0097323]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of T cell proliferation [GO:0042102]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12421943}; Single-pass type II membrane protein {ECO:0000269|PubMed:12421943}.
Q8IZS8	reviewed	CA2D3_HUMAN	Voltage-dependent calcium channel subunit alpha-2/delta-3 (Voltage-gated calcium channel subunit alpha-2/delta-3) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3]	CACNA2D3	Homo sapiens (Human)	1091	FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.	MISCELLANEOUS: In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug.	regulation of monoatomic ion transmembrane transport [GO:0034765]	voltage-gated calcium channel complex [GO:0005891]	metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]	voltage-gated calcium channel complex [GO:0005891]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8IZT9	reviewed	FAM9C_HUMAN	Protein FAM9C	FAM9C	Homo sapiens (Human)	166			meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286]	synaptonemal complex [GO:0000795]		synaptonemal complex [GO:0000795]; meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12213195}.
Q8IZU8	reviewed	DSEL_HUMAN	Dermatan-sulfate epimerase-like protein (EC 5.1.-.-)	DSEL C18orf4 NCAG1	Homo sapiens (Human)	1212			chondroitin sulfate metabolic process [GO:0030204]; dermatan sulfate biosynthetic process [GO:0030208]; dermatan sulfate metabolic process [GO:0030205]	Golgi membrane [GO:0000139]	chondroitin-glucuronate 5-epimerase activity [GO:0047757]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; chondroitin-glucuronate 5-epimerase activity [GO:0047757]; sulfotransferase activity [GO:0008146]; chondroitin sulfate metabolic process [GO:0030204]; dermatan sulfate biosynthetic process [GO:0030208]; dermatan sulfate metabolic process [GO:0030205]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8IZV2	reviewed	CKLF8_HUMAN	CKLF-like MARVEL transmembrane domain-containing protein 8 (Chemokine-like factor superfamily member 8)	CMTM8 CKLFSF8	Homo sapiens (Human)	173			chemotaxis [GO:0006935]; myelination [GO:0042552]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	cytokine activity [GO:0005125]; structural constituent of myelin sheath [GO:0019911]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; cytokine activity [GO:0005125]; structural constituent of myelin sheath [GO:0019911]; chemotaxis [GO:0006935]; myelination [GO:0042552]	SUBCELLULAR LOCATION: [Isoform 1]: Membrane; Multi-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.
Q8N0T1	reviewed	RBIS_HUMAN	Ribosomal biogenesis factor	RBIS C8orf59	Homo sapiens (Human)	100	FUNCTION: Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production. {ECO:0000269|PubMed:26711351}.		ribosome biogenesis [GO:0042254]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:26711351}.
Q8N0U2	reviewed	TMM61_HUMAN	Transmembrane protein 61	TMEM61	Homo sapiens (Human)	210				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N0Y7	reviewed	PGAM4_HUMAN	Probable phosphoglycerate mutase 4 (EC 5.4.2.11) (EC 5.4.2.4)	PGAM4 PGAM3	Homo sapiens (Human)	254		MISCELLANEOUS: This is the product of a processed gene created by retroposition from mRNA of an expressed gene. This gene seems to be expressed.	glycolytic process [GO:0006096]; positive regulation of flagellated sperm motility [GO:1902093]	extracellular exosome [GO:0070062]; sperm principal piece [GO:0097228]	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]; phosphoglycerate mutase activity [GO:0004619]	extracellular exosome [GO:0070062]; sperm principal piece [GO:0097228]; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]; phosphoglycerate mutase activity [GO:0004619]; glycolytic process [GO:0006096]; positive regulation of flagellated sperm motility [GO:1902093]	
Q8N0Z8	reviewed	PUSL1_HUMAN	tRNA pseudouridine synthase-like 1 (EC 5.4.99.-) (tRNA pseudouridylate synthase-like 1) (tRNA-uridine isomerase-like 1)	PUSL1	Homo sapiens (Human)	303			tRNA pseudouridine synthesis [GO:0031119]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]	pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthesis [GO:0031119]	
Q8N103	reviewed	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein)	TAGAP TAGAP1 FKSG15	Homo sapiens (Human)	731	FUNCTION: May function as a GTPase-activating protein and may play important roles during T-cell activation. {ECO:0000269|PubMed:15177553}.	MISCELLANEOUS: [Isoform 3]: Dubious isoform. The N-terminus appears to be derived from exons of the CEP43 locus which is located on the opposing strand of chromosome 6 at a distance of several Mb. {ECO:0000305}.	regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	
Q8N109	reviewed	KI2LA_HUMAN	Killer cell immunoglobulin-like receptor 2DL5A (CD antigen CD158f1)	KIR2DL5A CD158F CD158F1 KIR2DL5	Homo sapiens (Human)	375	FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.			plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q8N111	reviewed	CEND_HUMAN	Cell cycle exit and neuronal differentiation protein 1 (BM88 antigen)	CEND1 BM88	Homo sapiens (Human)	149	FUNCTION: Involved in neuronal differentiation. {ECO:0000250|UniProtKB:Q9JKC6}.		adult walking behavior [GO:0007628]; cerebellar granular layer maturation [GO:0021686]; cerebellar Purkinje cell differentiation [GO:0021702]; negative regulation of cerebellar granule cell precursor proliferation [GO:0021941]; radial glia guided migration of cerebellar granule cell [GO:0021933]	membrane [GO:0016020]		membrane [GO:0016020]; adult walking behavior [GO:0007628]; cerebellar granular layer maturation [GO:0021686]; cerebellar Purkinje cell differentiation [GO:0021702]; negative regulation of cerebellar granule cell precursor proliferation [GO:0021941]; radial glia guided migration of cerebellar granule cell [GO:0021933]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Q8N112	reviewed	LSME2_HUMAN	Leucine-rich single-pass membrane protein 2	LSMEM2 C3orf45	Homo sapiens (Human)	164				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8N118	reviewed	CP4X1_HUMAN	Cytochrome P450 4X1 (EC 1.14.14.-) (CYPIVX1)	CYP4X1 UNQ1929/PRO4404	Homo sapiens (Human)	509	FUNCTION: A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). {ECO:0000269|PubMed:18549450}.		lipid metabolic process [GO:0006629]	endoplasmic reticulum membrane [GO:0005789]	anandamide 14,15 epoxidase activity [GO:0062189]; heme binding [GO:0020037]; iron ion binding [GO:0005506]	endoplasmic reticulum membrane [GO:0005789]; anandamide 14,15 epoxidase activity [GO:0062189]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6A152}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:Q6A152}; Single-pass membrane protein {ECO:0000255}.
Q8N128	reviewed	F177A_HUMAN	Protein FAM177A1	FAM177A1 C14orf24	Homo sapiens (Human)	213							
Q8N143	reviewed	BCL6B_HUMAN	B-cell CLL/lymphoma 6 member B protein (Bcl6-associated zinc finger protein) (Zinc finger protein 62)	BCL6B BAZF ZNF62	Homo sapiens (Human)	479	FUNCTION: Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development. {ECO:0000269|PubMed:11855826}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	nucleoplasm [GO:0005654]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleoplasm [GO:0005654]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8N165	reviewed	PDK1L_HUMAN	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1-interacting kinase 1-like)	PDIK1L CLIK1L	Homo sapiens (Human)	341				cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; protein serine kinase activity [GO:0106310]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14631099}.
Q8N184	reviewed	ZN567_HUMAN	Zinc finger protein 567	ZNF567	Homo sapiens (Human)	647	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N1D0	reviewed	BWR1B_HUMAN	Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein (Organic cation transporter-like protein 2 antisense protein) (Solute carrier family 22 member 1-like antisense protein) (Solute carrier family 22 member 18 antisense protein) (p27-Beckwith-Wiedemann region 1 B) (p27-BWR1B)	SLC22A18AS BWR1B BWSCR1B ORCTL2S SLC22A1LS	Homo sapiens (Human)	253							
Q8N1G4	reviewed	LRC47_HUMAN	Leucine-rich repeat-containing protein 47	LRRC47 KIAA1185	Homo sapiens (Human)	583			phenylalanyl-tRNA aminoacylation [GO:0006432]		phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723]	phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723]; phenylalanyl-tRNA aminoacylation [GO:0006432]	
Q8N1S5	reviewed	S39AB_HUMAN	Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) (ZIP-11)	SLC39A11 C17orf26 ZIP11	Homo sapiens (Human)	342	FUNCTION: Zinc importer that regulates cytosolic zinc concentrations either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q8BWY7}.		zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	copper ion transmembrane transporter activity [GO:0005375]; zinc ion transmembrane transporter activity [GO:0005385]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; copper ion transmembrane transporter activity [GO:0005375]; zinc ion transmembrane transporter activity [GO:0005385]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BWY7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8BWY7}. Nucleus {ECO:0000250|UniProtKB:Q8BWY7}. Cytoplasm {ECO:0000250|UniProtKB:Q8BWY7}. Golgi apparatus {ECO:0000250|UniProtKB:Q8BWY7}.
Q8N292	reviewed	GAPT_HUMAN	Protein GAPT (GRB2-binding adapter protein, transmembrane) (Growth factor receptor-bound protein 2-binding adapter protein, transmembrane)	GAPT C5orf29	Homo sapiens (Human)	157	FUNCTION: Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity). {ECO:0000250}.		B cell homeostasis [GO:0001782]; B cell proliferation involved in immune response [GO:0002322]	Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]		Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; B cell homeostasis [GO:0001782]; B cell proliferation involved in immune response [GO:0002322]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18559951}; Single-pass membrane protein {ECO:0000269|PubMed:18559951}.
Q8N2E2	reviewed	VWDE_HUMAN	von Willebrand factor D and EGF domain-containing protein	VWDE	Homo sapiens (Human)	1590			anatomical structure development [GO:0048856]	cell surface [GO:0009986]; extracellular region [GO:0005576]	signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]; signaling receptor binding [GO:0005102]; anatomical structure development [GO:0048856]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N2H3	reviewed	PYRD2_HUMAN	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC 1.-.-.-)	PYROXD2 C10orf33	Homo sapiens (Human)	581	FUNCTION: Probable oxidoreductase that may play a role as regulator of mitochondrial function. {ECO:0000269|PubMed:31170524}.		mitochondrion organization [GO:0007005]	mitochondrial matrix [GO:0005759]	oxidoreductase activity [GO:0016491]	mitochondrial matrix [GO:0005759]; oxidoreductase activity [GO:0016491]; mitochondrion organization [GO:0007005]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:31170524}. Note=The import into mitochondria is dependent on TOMM40 and TIMM23. {ECO:0000269|PubMed:31170524}.
Q8N365	reviewed	CIART_HUMAN	Circadian-associated transcriptional repressor (ChIP-derived repressor of network oscillator) (Chrono) (Computationally highlighted repressor of the network oscillator)	CIART C1orf51	Homo sapiens (Human)	385	FUNCTION: Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Abrogates the interaction of BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity). {ECO:0000250}.		circadian regulation of gene expression [GO:0032922]; locomotor rhythm [GO:0045475]; negative regulation of DNA-templated transcription [GO:0045892]	nucleus [GO:0005634]; PML body [GO:0016605]	E-box binding [GO:0070888]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; PML body [GO:0016605]; E-box binding [GO:0070888]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; circadian regulation of gene expression [GO:0032922]; locomotor rhythm [GO:0045475]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Co-localizes with the CLOCK-BMAL1 heterodimer in the PML body. {ECO:0000250}.
Q8N3D4	reviewed	EH1L1_HUMAN	EH domain-binding protein 1-like protein 1	EHBP1L1	Homo sapiens (Human)	1523	FUNCTION: May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}.			endosome [GO:0005768]; membrane [GO:0016020]		endosome [GO:0005768]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Endosome {ECO:0000305|PubMed:27552051}.
Q8N3J9	reviewed	ZN664_HUMAN	Zinc finger protein 664 (Zinc finger protein 176) (Zinc finger protein from organ of Corti)	ZNF664 ZFOC1 ZNF176	Homo sapiens (Human)	261	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N3X1	reviewed	FNBP4_HUMAN	Formin-binding protein 4 (Formin-binding protein 30)	FNBP4 FBP30 KIAA1014	Homo sapiens (Human)	1017				nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	
Q8N3X6	reviewed	LCORL_HUMAN	Ligand-dependent nuclear receptor corepressor-like protein (LCoR-like protein)	LCORL	Homo sapiens (Human)	602	FUNCTION: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; histone methyltransferase binding [GO:1990226]	nucleus [GO:0005634]; DNA binding [GO:0003677]; histone methyltransferase binding [GO:1990226]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320}.
Q8N436	reviewed	CPXM2_HUMAN	Inactive carboxypeptidase-like protein X2	CPXM2 CPX2 UNQ676/PRO1310	Homo sapiens (Human)	756	FUNCTION: May be involved in cell-cell interactions.		peptide metabolic process [GO:0006518]; protein processing [GO:0016485]	extracellular space [GO:0005615]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	extracellular space [GO:0005615]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; peptide metabolic process [GO:0006518]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N442	reviewed	GUF1_HUMAN	Translation factor GUF1, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase GUF1) (Ribosomal back-translocase)	GUF1	Homo sapiens (Human)	669	FUNCTION: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. {ECO:0000255|HAMAP-Rule:MF_03137}.		positive regulation of translation [GO:0045727]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; mitochondrial ribosome binding [GO:0097177]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; mitochondrial ribosome binding [GO:0097177]; positive regulation of translation [GO:0045727]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03137}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03137}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03137}.
Q8N461	reviewed	FXL16_HUMAN	F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16)	FBXL16 C16orf22 FBL16	Homo sapiens (Human)	479	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.		SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]		cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	
Q8N475	reviewed	FSTL5_HUMAN	Follistatin-related protein 5 (Follistatin-like protein 5)	FSTL5 KIAA1263	Homo sapiens (Human)	847			cell differentiation [GO:0030154]; regulation of BMP signaling pathway [GO:0030510]	extracellular region [GO:0005576]	calcium ion binding [GO:0005509]	extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; cell differentiation [GO:0030154]; regulation of BMP signaling pathway [GO:0030510]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N4G2	reviewed	ARL14_HUMAN	ADP-ribosylation factor-like protein 14 (ADP-ribosylation factor 7)	ARL14 ARF7	Homo sapiens (Human)	192	FUNCTION: GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. {ECO:0000269|PubMed:21458045}.		intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	cytoplasmic vesicle [GO:0031410]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasmic vesicle [GO:0031410]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:21458045}. Note=Colocalizes with MHC II-containing cytoplasmic vesicles.
Q8N4H5	reviewed	TOM5_HUMAN	Mitochondrial import receptor subunit TOM5 homolog	TOMM5 C9orf105 TOM5	Homo sapiens (Human)	51			protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]	mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]		mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18331822}; Single-pass membrane protein {ECO:0000269|PubMed:18331822}.
Q8N4P2	reviewed	IT70B_HUMAN	Intraflagellar transport protein 70B (Tetratricopeptide repeat protein 30B) (TPR repeat protein 30B)	IFT70B TTC30B	Homo sapiens (Human)	665	FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. {ECO:0000250}.		cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]	axonemal microtubule [GO:0005879]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]	intraciliary transport particle B binding [GO:0120170]	axonemal microtubule [GO:0005879]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]; intraciliary transport particle B binding [GO:0120170]; cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
Q8N4Q0	reviewed	PTGR3_HUMAN	Prostaglandin reductase 3 (PRG-3) (EC 1.3.1.48) (Zinc-binding alcohol dehydrogenase domain-containing protein 2)	PTGR3 ZADH2	Homo sapiens (Human)	377	FUNCTION: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. {ECO:0000250|UniProtKB:Q8BGC4}.		negative regulation of fat cell differentiation [GO:0045599]	peroxisome [GO:0005777]	13-prostaglandin reductase activity [GO:0036132]; 15-oxoprostaglandin 13-oxidase activity [GO:0047522]; zinc ion binding [GO:0008270]	peroxisome [GO:0005777]; 13-prostaglandin reductase activity [GO:0036132]; 15-oxoprostaglandin 13-oxidase activity [GO:0047522]; zinc ion binding [GO:0008270]; negative regulation of fat cell differentiation [GO:0045599]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q8BGC4}.
Q8N4T4	reviewed	ARG39_HUMAN	Rho guanine nucleotide exchange factor 39	ARHGEF39 C9orf100	Homo sapiens (Human)	335	FUNCTION: Promotes cell proliferation. {ECO:0000269|PubMed:22327280}.		positive regulation of cell migration [GO:0030335]	plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; positive regulation of cell migration [GO:0030335]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22327280}.
Q8N4U5	reviewed	T11L2_HUMAN	T-complex protein 11-like protein 2	TCP11L2	Homo sapiens (Human)	519	FUNCTION: Promotes the migration of muscle-derived satellite cells (MDSCs) during differentiation throught interaction with FMNL2 and therefore may participate in microfilament assembly. {ECO:0000250|UniProtKB:A7Z033}.		muscle cell migration [GO:0014812]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; muscle cell migration [GO:0014812]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A7Z033}. Note=Accumulates around the actin complex before the formation of microfilament bundles and microtubule extension. {ECO:0000250|UniProtKB:A7Z033}.
Q8N4W9	reviewed	ZN808_HUMAN	Zinc finger protein 808	ZNF808	Homo sapiens (Human)	903	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N5C7	reviewed	DTWD1_HUMAN	tRNA-uridine aminocarboxypropyltransferase 1 (EC 2.5.1.25) (DTW domain-containing protein 1)	DTWD1 MDS009	Homo sapiens (Human)	304	FUNCTION: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)). {ECO:0000269|PubMed:31804502}.		tRNA modification [GO:0006400]	nucleus [GO:0005634]	tRNA-uridine aminocarboxypropyltransferase activity [GO:0016432]	nucleus [GO:0005634]; tRNA-uridine aminocarboxypropyltransferase activity [GO:0016432]; tRNA modification [GO:0006400]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31804502}.
Q8N5I3	reviewed	KCNRG_HUMAN	Potassium channel regulatory protein (Potassium channel regulator) (Protein CLLD4)	KCNRG CLLD4	Homo sapiens (Human)	272	FUNCTION: Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes. {ECO:0000269|PubMed:12650944, ECO:0000269|PubMed:19968958}.		negative regulation of delayed rectifier potassium channel activity [GO:1902260]; protein homooligomerization [GO:0051260]	endoplasmic reticulum [GO:0005783]	identical protein binding [GO:0042802]	endoplasmic reticulum [GO:0005783]; identical protein binding [GO:0042802]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:19968958}.
Q8N5L8	reviewed	RP25L_HUMAN	Ribonuclease P protein subunit p25-like protein (RNase P protein subunit-like p25) (Rpp25-like protein)	RPP25L C9orf23	Homo sapiens (Human)	163	FUNCTION: May be a component of ribonuclease P or MRP.		tRNA 5'-leader removal [GO:0001682]	nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]	RNA binding [GO:0003723]	nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]; RNA binding [GO:0003723]; tRNA 5'-leader removal [GO:0001682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N5M4	reviewed	TTC9C_HUMAN	Tetratricopeptide repeat protein 9C (TPR repeat protein 9C)	TTC9C	Homo sapiens (Human)	171							
Q8N5N7	reviewed	RM50_HUMAN	Large ribosomal subunit protein mL50 (39S ribosomal protein L50, mitochondrial) (L50mt) (MRP-L50)	MRPL50	Homo sapiens (Human)	158			mitochondrial translation [GO:0032543]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q8N5R6	reviewed	CCD33_HUMAN	Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61)	CCDC33	Homo sapiens (Human)	958				peroxisome [GO:0005777]		peroxisome [GO:0005777]	
Q8N5S1	reviewed	S2541_HUMAN	Mitochondrial carrier protein SCaMC-3L (Mitochondrial ATP-Mg/Pi carrier protein SLC25A41) (Small calcium-binding mitochondrial carrier protein 3-like) (SCaMC-3-like) (SCaMC-3L) (Solute carrier family 25 member 41)	SLC25A41	Homo sapiens (Human)	370	FUNCTION: Calcium-independent ATP-Mg/Pi exchanger that catalyzes the electroneutral exchange of Mg-ATP or free ADP against an hydrogenphosphate and participates in the net transport of adenine nucleotides across the mitochondria inner membrane. {ECO:0000250|UniProtKB:Q8BVN7}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	ADP transport [GO:0015866]; ATP transport [GO:0015867]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	ADP transmembrane transporter activity [GO:0015217]; ATP transmembrane transporter activity [GO:0005347]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ADP transmembrane transporter activity [GO:0015217]; ATP transmembrane transporter activity [GO:0005347]; ADP transport [GO:0015866]; ATP transport [GO:0015867]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8BVN7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O94502}.
Q8N628	reviewed	OR2C3_HUMAN	Olfactory receptor 2C3 (Olfactory receptor 2C4) (Olfactory receptor 2C5) (Olfactory receptor OR1-30)	OR2C3 OR2C4 OR2C5P	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8N690	reviewed	DB119_HUMAN	Beta-defensin 119 (Beta-defensin 120) (Beta-defensin 19) (DEFB-19) (Beta-defensin 20) (DEFB-20) (Defensin, beta 119) (Defensin, beta 120) (ESC42-RELA)	DEFB119 DEFB120 DEFB19 DEFB20 UNQ2449/PRO5729	Homo sapiens (Human)	84	FUNCTION: Has antibacterial activity. {ECO:0000305}.	MISCELLANEOUS: [Isoform 3]: Abundantly expressed in testis. {ECO:0000305}.	antifungal innate immune response [GO:0061760]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]	extracellular region [GO:0005576]	lipopolysaccharide binding [GO:0001530]	extracellular region [GO:0005576]; lipopolysaccharide binding [GO:0001530]; antifungal innate immune response [GO:0061760]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N699	reviewed	MYCT1_HUMAN	Myc target protein 1 (Myc target in myeloid cells protein 1)	MYCT1 MTLC MTMC1	Homo sapiens (Human)	235	FUNCTION: May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity). {ECO:0000250}.		hematopoietic stem cell homeostasis [GO:0061484]	intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]		intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; hematopoietic stem cell homeostasis [GO:0061484]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12673574}. Note=Expressed in nuclei of hepatocellular carcinoma cell line BEL-7402 cells.
Q8N6D5	reviewed	ANR29_HUMAN	Ankyrin repeat domain-containing protein 29	ANKRD29	Homo sapiens (Human)	301							
Q8N6S5	reviewed	AR6P6_HUMAN	ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6) (Phosphonoformate immuno-associated protein 1)	ARL6IP6 PFAAP1	Homo sapiens (Human)	226				nuclear inner membrane [GO:0005637]		nuclear inner membrane [GO:0005637]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:Q8BH07}; Multi-pass membrane protein {ECO:0000255}.
Q8N6T0	reviewed	TO6BL_HUMAN	Type 2 DNA topoisomerase 6 subunit B-like (TOP6B like initiator of meiotic double strand breaks) (Type 2 DNA topoisomerase VI subunit B-like) (TOPOVIBL)	TOP6BL C11orf80	Homo sapiens (Human)	577	FUNCTION: [Isoform 3]: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. {ECO:0000250|UniProtKB:J3QMY9}.	MISCELLANEOUS: Expansion of a polymorphic CGG repeat within the 5'-UTR of this gene may be the cause of folate-sensitive fragile site FRA11A. The expansion is identified in the 15-year-old proband with intellectual disability as well as in phenotypically normal members of the family. {ECO:0000269|PubMed:18160775}.; MISCELLANEOUS: [Isoform 1]: Contains a signal peptide sequence at position 1-23. {ECO:0000255}.	meiotic DNA double-strand break formation [GO:0042138]; reciprocal meiotic recombination [GO:0007131]	chromosome [GO:0005694]		chromosome [GO:0005694]; meiotic DNA double-strand break formation [GO:0042138]; reciprocal meiotic recombination [GO:0007131]	SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:J3QMY9}. Note=Localizes to meiotic chromosomes. {ECO:0000250|UniProtKB:J3QMY9}.
Q8N6Y1	reviewed	PCD20_HUMAN	Protocadherin-20 (Protocadherin-13)	PCDH20 PCDH13	Homo sapiens (Human)	951	FUNCTION: Potential calcium-dependent cell-adhesion protein.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; RNA binding [GO:0003723]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; RNA binding [GO:0003723]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q8N729	reviewed	NPW_HUMAN	Neuropeptide W (Preproprotein L8) (hPPL8) [Cleaved into: Neuropeptide W-23 (NPW23) (hL8); Neuropeptide W-30 (NPW30) (hL8C)]	NPW PPL8 PPNPW	Homo sapiens (Human)	165	FUNCTION: Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. {ECO:0000250}.		feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	extracellular region [GO:0005576]	G protein-coupled receptor binding [GO:0001664]	extracellular region [GO:0005576]; G protein-coupled receptor binding [GO:0001664]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313}.
Q8N7A1	reviewed	KLDC1_HUMAN	Kelch domain-containing protein 1	KLHDC1 MSTP025	Homo sapiens (Human)	406	FUNCTION: Substrate-recognition component of a Cul5-RING (CRL5) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:32200094). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:32200094). The CRL5(KLHDC1) complex mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine (PubMed:32200094). {ECO:0000269|PubMed:32200094}.		protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	ubiquitin ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16964437, ECO:0000269|PubMed:32200094}.
Q8N7B1	reviewed	HORM2_HUMAN	HORMA domain-containing protein 2	HORMAD2	Homo sapiens (Human)	307	FUNCTION: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity). {ECO:0000250}.		meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177]	centrosome [GO:0005813]; chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]		centrosome [GO:0005813]; chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]; meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22893617}. Chromosome {ECO:0000250}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes (By similarity). {ECO:0000250}.
Q8N7B9	reviewed	EFCB3_HUMAN	EF-hand calcium-binding domain-containing protein 3	EFCAB3	Homo sapiens (Human)	438					calcium ion binding [GO:0005509]	calcium ion binding [GO:0005509]	
Q8N7K0	reviewed	ZN433_HUMAN	Zinc finger protein 433	ZNF433	Homo sapiens (Human)	673	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N7M2	reviewed	ZN283_HUMAN	Zinc finger protein 283 (Zinc finger protein HZF19)	ZNF283	Homo sapiens (Human)	679	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N7P1	reviewed	PLD5_HUMAN	Inactive phospholipase D5 (Inactive PLD 5) (Inactive choline phosphatase 5) (Inactive phosphatidylcholine-hydrolyzing phospholipase D5) (PLDc)	PLD5	Homo sapiens (Human)	536				cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; membrane [GO:0016020]	catalytic activity [GO:0003824]	cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; membrane [GO:0016020]; catalytic activity [GO:0003824]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8N7P3	reviewed	CLD22_HUMAN	Claudin-22	CLDN22	Homo sapiens (Human)	220	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q8N7X0	reviewed	ADGB_HUMAN	Androglobin (Calpain-7-like protein)	ADGB C6orf103 CAPN7L	Homo sapiens (Human)	1667	FUNCTION: Required for sperm flagellum formation and maturation of elongating spermatids, thus playing an essential role in male fertility. Contributes to in vitro proteolytic cleavage of SEPT10 in a calmodulin-dependent manner. {ECO:0000250|UniProtKB:G3UZ78}.		cell differentiation [GO:0030154]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	motile cilium [GO:0031514]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; heme binding [GO:0020037]; oxygen binding [GO:0019825]	motile cilium [GO:0031514]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; heme binding [GO:0020037]; oxygen binding [GO:0019825]; cell differentiation [GO:0030154]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:G3UZ78}. Note=Expressed within the midpiece and along the whole sperm flagellum. Detected in the annulus of the sperm flagellum in S12 and S15 spermatids and mature sperm. {ECO:0000250|UniProtKB:G3UZ78}.
Q8N801	reviewed	STPG4_HUMAN	Protein STPG4 (Gonad-specific expression gene protein) (GSE) (Sperm-tail PG-rich repeat-containing protein 4)	STPG4 C2orf61	Homo sapiens (Human)	248	FUNCTION: Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). {ECO:0000250|UniProtKB:Q9DAG5}.		C-5 methylation of cytosine [GO:0090116]; epigenetic programing of male pronucleus [GO:0044727]; positive regulation of DNA demethylation [GO:1901537]	cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; germinal vesicle [GO:0042585]; male germ cell nucleus [GO:0001673]; male pronucleus [GO:0001940]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; germinal vesicle [GO:0042585]; male germ cell nucleus [GO:0001673]; male pronucleus [GO:0001940]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; C-5 methylation of cytosine [GO:0090116]; epigenetic programing of male pronucleus [GO:0044727]; positive regulation of DNA demethylation [GO:1901537]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9DAG5}. Nucleus {ECO:0000250|UniProtKB:Q9DAG5}. Note=Localizes in female and male zygote pronucleus. Associates preferentially with the paternal chromatin during zygote development. {ECO:0000250|UniProtKB:Q9DAG5}.
Q8N806	reviewed	UBR7_HUMAN	Putative E3 ubiquitin-protein ligase UBR7 (EC 2.3.2.27) (N-recognin-7) (RING-type E3 ubiquitin transferase UBR7)	UBR7 C14orf130	Homo sapiens (Human)	425	FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. {ECO:0000250}.		protein ubiquitination [GO:0016567]		ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]	
Q8N819	reviewed	PPM1N_HUMAN	Probable protein phosphatase 1N (EC 3.1.3.16)	PPM1N	Homo sapiens (Human)	430			negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of canonical Wnt signaling pathway [GO:0090263]	cytosol [GO:0005829]; nucleus [GO:0005634]	magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; nucleus [GO:0005634]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of canonical Wnt signaling pathway [GO:0090263]	
Q8N823	reviewed	ZN611_HUMAN	Zinc finger protein 611	ZNF611	Homo sapiens (Human)	705	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N831	reviewed	TSYL6_HUMAN	Testis-specific Y-encoded-like protein 6 (TSPY-like protein 6)	TSPYL6	Homo sapiens (Human)	410			nucleosome assembly [GO:0006334]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; nucleosome assembly [GO:0006334]	
Q8N859	reviewed	ZN713_HUMAN	Zinc finger protein 713	ZNF713	Homo sapiens (Human)	443	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N883	reviewed	ZN614_HUMAN	Zinc finger protein 614	ZNF614	Homo sapiens (Human)	585	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N8A2	reviewed	ANR44_HUMAN	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44)	ANKRD44	Homo sapiens (Human)	993	FUNCTION: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.						
Q8N8A6	reviewed	DDX51_HUMAN	ATP-dependent RNA helicase DDX51 (EC 3.6.4.13) (DEAD box protein 51)	DDX51	Homo sapiens (Human)	666	FUNCTION: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. {ECO:0000250}.		rRNA processing [GO:0006364]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
Q8N8E3	reviewed	CE112_HUMAN	Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46)	CEP112 CCDC46	Homo sapiens (Human)	955			receptor localization to synapse [GO:0097120]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]; receptor localization to synapse [GO:0097120]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes around spindle poles in some cells. {ECO:0000269|PubMed:21399614}.
Q8N8F6	reviewed	YIPF7_HUMAN	Protein YIPF7 (Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 9) (YIP1 family member 7)	YIPF7 FINGER9 YIP1B	Homo sapiens (Human)	280			endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle fusion with Golgi apparatus [GO:0048280]	endoplasmic reticulum membrane [GO:0005789]; trans-Golgi network [GO:0005802]		endoplasmic reticulum membrane [GO:0005789]; trans-Golgi network [GO:0005802]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle fusion with Golgi apparatus [GO:0048280]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9JIM5}; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27999994}. Note=Evenly distributed between cis- and trans-Golgi apparatus. {ECO:0000269|PubMed:27999994}.
Q8N8G2	reviewed	VGLL2_HUMAN	Transcription cofactor vestigial-like protein 2 (Vgl-2) (Protein VITO1)	VGLL2 VITO1	Homo sapiens (Human)	317	FUNCTION: May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.		positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue development [GO:0007519]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8N8J6	reviewed	ZN615_HUMAN	Zinc finger protein 615	ZNF615	Homo sapiens (Human)	731	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N8K9	reviewed	K1958_HUMAN	Uncharacterized protein KIAA1958	KIAA1958	Homo sapiens (Human)	716							
Q8N8L2	reviewed	ZN491_HUMAN	Zinc finger protein 491	ZNF491	Homo sapiens (Human)	437	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N8Q9	reviewed	NIPA2_HUMAN	Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2)	NIPA2	Homo sapiens (Human)	360	FUNCTION: Acts as a selective Mg(2+) transporter. {ECO:0000269|PubMed:25347071}.		magnesium ion transport [GO:0015693]	early endosome [GO:0005769]; membrane [GO:0016020]; plasma membrane [GO:0005886]	magnesium ion transmembrane transporter activity [GO:0015095]	early endosome [GO:0005769]; membrane [GO:0016020]; plasma membrane [GO:0005886]; magnesium ion transmembrane transporter activity [GO:0015095]; magnesium ion transport [GO:0015693]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25347071}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000250|UniProtKB:Q9JJC8}. Note=Recruited to the cell membrane in response to low extracellular magnesium. {ECO:0000250|UniProtKB:Q9JJC8}.
Q8N8R5	reviewed	CB069_HUMAN	Mitochondrial protein C2orf69	C2orf69	Homo sapiens (Human)	385	FUNCTION: May play a role in the respiratory chain. {ECO:0000269|PubMed:33945503}.		oxidative phosphorylation [GO:0006119]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; respirasome [GO:0070469]		mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; respirasome [GO:0070469]; oxidative phosphorylation [GO:0006119]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:33945503}.
Q8N8Y5	reviewed	ZFP41_HUMAN	Zinc finger protein 41 homolog (Zfp-41)	ZFP41	Homo sapiens (Human)	198	FUNCTION: A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8N8Z8	reviewed	ZN441_HUMAN	Zinc finger protein 441	ZNF441	Homo sapiens (Human)	693	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N907	reviewed	DAND5_HUMAN	DAN domain family member 5 (Cerberus-like protein 2) (Cerl-2) (Cysteine knot superfamily 1, BMP antagonist 3) (Gremlin-3)	DAND5 CER2 CKTSF1B3 GREM3 SP1	Homo sapiens (Human)	189	FUNCTION: Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity). {ECO:0000250}.		atrial septum development [GO:0003283]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of nodal signaling pathway [GO:1900108]; negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900176]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; sequestering of BMP in extracellular matrix [GO:0035582]; sequestering of nodal from receptor via nodal binding [GO:0038101]; signal transduction involved in regulation of gene expression [GO:0023019]; ventricular septum development [GO:0003281]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	morphogen activity [GO:0016015]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; morphogen activity [GO:0016015]; atrial septum development [GO:0003283]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of nodal signaling pathway [GO:1900108]; negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900176]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; sequestering of BMP in extracellular matrix [GO:0035582]; sequestering of nodal from receptor via nodal binding [GO:0038101]; signal transduction involved in regulation of gene expression [GO:0023019]; ventricular septum development [GO:0003281]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N954	reviewed	GPT11_HUMAN	G patch domain-containing protein 11 (Coiled-coil domain-containing protein 75)	GPATCH11 CCDC75 CENP-Y	Homo sapiens (Human)	285				kinetochore [GO:0000776]	nucleic acid binding [GO:0003676]	kinetochore [GO:0000776]; nucleic acid binding [GO:0003676]	SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
Q8N988	reviewed	ZN557_HUMAN	Zinc finger protein 557	ZNF557	Homo sapiens (Human)	423	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N9H8	reviewed	MUT7_HUMAN	Exonuclease mut-7 homolog (EC 3.1.-.-) (Exonuclease 3'-5' domain-containing protein 3)	EXD3 HBE269	Homo sapiens (Human)	876	FUNCTION: Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity). {ECO:0000250}.		nucleobase-containing compound metabolic process [GO:0006139]		3'-5' exonuclease activity [GO:0008408]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]	3'-5' exonuclease activity [GO:0008408]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; nucleobase-containing compound metabolic process [GO:0006139]	
Q8N9L1	reviewed	ZIC4_HUMAN	Zinc finger protein ZIC 4 (Zinc finger protein of the cerebellum 4)	ZIC4	Homo sapiens (Human)	334	FUNCTION: Binds to DNA. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.	central nervous system development [GO:0007417]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; central nervous system development [GO:0007417]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8N9S9	reviewed	SNX31_HUMAN	Sorting nexin-31	SNX31	Homo sapiens (Human)	440	FUNCTION: May be involved in protein trafficking. {ECO:0000305|PubMed:28892079}.		intracellular protein transport [GO:0006886]	early endosome [GO:0005769]; protein-containing complex [GO:0032991]	phosphatidylinositol binding [GO:0035091]	early endosome [GO:0005769]; protein-containing complex [GO:0032991]; phosphatidylinositol binding [GO:0035091]; intracellular protein transport [GO:0006886]	
Q8N9V2	reviewed	TRIML_HUMAN	Probable E3 ubiquitin-protein ligase TRIML1 (EC 2.3.2.27) (RING finger protein 209) (RING-type E3 ubiquitin transferase TRIML1) (Tripartite motif family-like protein 1)	TRIML1 RNF209	Homo sapiens (Human)	468	FUNCTION: Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development. {ECO:0000250|UniProtKB:Q8BVP1}.		innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
Q8N9W4	reviewed	GG6L2_HUMAN	Golgin subfamily A member 6-like protein 2	GOLGA6L2	Homo sapiens (Human)	909							
Q8N9Z0	reviewed	ZN610_HUMAN	Zinc finger protein 610	ZNF610	Homo sapiens (Human)	462	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NA19	reviewed	LMBL4_HUMAN	Lethal(3)malignant brain tumor-like protein 4 (H-l(3)mbt-like protein 4) (L(3)mbt-like protein 4) (L3mbt-like 4)	L3MBTL4	Homo sapiens (Human)	623	FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). {ECO:0000250}.		chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NAA4	reviewed	A16L2_HUMAN	Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80)	ATG16L2 WDR80	Homo sapiens (Human)	619	FUNCTION: May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner. {ECO:0000250|UniProtKB:Q6KAU8}.	MISCELLANEOUS: Although ATG16L2 is structurally similar to ATG16L1 and is likewise able to form a complex with the autophagy proteins ATG5 and ATG12, overexpression and knockdown studies in mouse suggest that ATG16L2 is not essential for canonical autophagy. {ECO:0000250|UniProtKB:Q6KAU8}.	autophagosome assembly [GO:0000045]; macroautophagy [GO:0016236]; negative stranded viral RNA replication [GO:0039689]; protein transport [GO:0015031]	Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; phagophore assembly site membrane [GO:0034045]		Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; phagophore assembly site membrane [GO:0034045]; autophagosome assembly [GO:0000045]; macroautophagy [GO:0016236]; negative stranded viral RNA replication [GO:0039689]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6KAU8}. Note=Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250|UniProtKB:Q6KAU8}.
Q8NAF0	reviewed	ZN579_HUMAN	Zinc finger protein 579	ZNF579	Homo sapiens (Human)	562	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NAT2	reviewed	TDRD5_HUMAN	Tudor domain-containing protein 5	TDRD5 TUDOR3	Homo sapiens (Human)	981	FUNCTION: Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity). {ECO:0000250}.		P granule organization [GO:0030719]; piRNA processing [GO:0034587]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	chromatoid body [GO:0033391]; P granule [GO:0043186]; pi-body [GO:0071546]; synapse [GO:0045202]		chromatoid body [GO:0033391]; P granule [GO:0043186]; pi-body [GO:0071546]; synapse [GO:0045202]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis. {ECO:0000250}.
Q8NB91	reviewed	FANCB_HUMAN	Fanconi anemia group B protein (Protein FACB) (Fanconi anemia-associated polypeptide of 95 kDa) (FAAP95)	FANCB	Homo sapiens (Human)	859	FUNCTION: DNA repair protein required for FANCD2 ubiquitination. {ECO:0000269|PubMed:15502827}.		interstrand cross-link repair [GO:0036297]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]	chromatin [GO:0000785]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]		chromatin [GO:0000785]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; interstrand cross-link repair [GO:0036297]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15502827}.
Q8NBA8	reviewed	DTWD2_HUMAN	tRNA-uridine aminocarboxypropyltransferase 2 (EC 2.5.1.25) (DTW domain-containing protein 2)	DTWD2	Homo sapiens (Human)	298	FUNCTION: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)) (PubMed:31804502). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)) (PubMed:31804502). {ECO:0000269|PubMed:31804502}.		tRNA modification [GO:0006400]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	tRNA-uridine aminocarboxypropyltransferase activity [GO:0016432]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; tRNA-uridine aminocarboxypropyltransferase activity [GO:0016432]; tRNA modification [GO:0006400]	SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:31804502}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:31804502}. Cytoplasm {ECO:0000269|PubMed:31804502}. Note=Localizes mainly in the nucleus. {ECO:0000269|PubMed:31804502}.
Q8NBF6	reviewed	AVL9_HUMAN	Late secretory pathway protein AVL9 homolog	AVL9 KIAA0241	Homo sapiens (Human)	648	FUNCTION: Functions in cell migration. {ECO:0000269|PubMed:22595670}.		cell migration [GO:0016477]	cytoplasm [GO:0005737]; membrane [GO:0016020]; recycling endosome [GO:0055037]		cytoplasm [GO:0005737]; membrane [GO:0016020]; recycling endosome [GO:0055037]; cell migration [GO:0016477]	SUBCELLULAR LOCATION: Recycling endosome {ECO:0000269|PubMed:22595670}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8NBH2	reviewed	KY_HUMAN	Kyphoscoliosis peptidase (EC 3.4.-.-)	KY	Homo sapiens (Human)	661	FUNCTION: Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity). {ECO:0000250}.		muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]	peptidase activity [GO:0008233]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]; peptidase activity [GO:0008233]; muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
Q8NBM8	reviewed	PCYXL_HUMAN	Prenylcysteine oxidase-like (EC 1.8.3.-)	PCYOX1L PSEC0105	Homo sapiens (Human)	494	FUNCTION: Probable oxidoreductase. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328]	extracellular region [GO:0005576]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]	prenylcysteine oxidase activity [GO:0001735]	extracellular region [GO:0005576]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; prenylcysteine oxidase activity [GO:0001735]; prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328]	SUBCELLULAR LOCATION: Secreted.
Q8NBR0	reviewed	P5I13_HUMAN	Tumor protein p53-inducible protein 13 (Damage-stimulated cytoplasmic protein 1)	TP53I13 DSCP1	Homo sapiens (Human)	393	FUNCTION: May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed. {ECO:0000269|PubMed:14767535}.		negative regulation of cell cycle [GO:0045786]; response to organic cyclic compound [GO:0014070]; response to UV [GO:0009411]; response to xenobiotic stimulus [GO:0009410]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; negative regulation of cell cycle [GO:0045786]; response to organic cyclic compound [GO:0014070]; response to UV [GO:0009411]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:14767535}. Note=Associates with unknown subcellular structures in the cytoplasm.
Q8NBV4	reviewed	PLPP7_HUMAN	Inactive phospholipid phosphatase 7 (Phosphatidic acid phosphatase type 2 domain-containing protein 3)	PLPP7 C9orf67 PPAPDC3	Homo sapiens (Human)	271	FUNCTION: Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity). {ECO:0000250}.		negative regulation of myotube differentiation [GO:0010832]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]	sphingosine-1-phosphate phosphatase activity [GO:0042392]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; sphingosine-1-phosphate phosphatase activity [GO:0042392]; negative regulation of myotube differentiation [GO:0010832]	SUBCELLULAR LOCATION: Nucleus envelope. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein. Note=Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm. {ECO:0000250}.
Q8NBX0	reviewed	SCPDL_HUMAN	Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-)	SCCPDH CGI-49	Homo sapiens (Human)	429			glycolipid biosynthetic process [GO:0009247]	extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]	oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; oxidoreductase activity [GO:0016491]; glycolipid biosynthetic process [GO:0009247]	
Q8NC96	reviewed	NECP1_HUMAN	Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1)	NECAP1	Homo sapiens (Human)	275	FUNCTION: Involved in endocytosis. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	endocytosis [GO:0006897]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]		clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endocytosis [GO:0006897]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with AP-2 at the plasma membrane. {ECO:0000250}.
Q8NCA9	reviewed	ZN784_HUMAN	Zinc finger protein 784	ZNF784	Homo sapiens (Human)	323	FUNCTION: May be involved in transcriptional regulation.		hematopoietic progenitor cell differentiation [GO:0002244]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NCF0	reviewed	CL18C_HUMAN	C-type lectin domain family 18 member C (Mannose receptor-like protein 3)	CLEC18C MRLP3	Homo sapiens (Human)	446	FUNCTION: Binds polysaccharidesin a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans. {ECO:0000269|PubMed:26170455}.			endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]	polysaccharide binding [GO:0030247]	endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; polysaccharide binding [GO:0030247]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A5D8T8}. Endoplasmic reticulum {ECO:0000305|PubMed:26170455}. Golgi apparatus {ECO:0000305|PubMed:26170455}. Endosome {ECO:0000305|PubMed:26170455}.
Q8NCK3	reviewed	ZN485_HUMAN	Zinc finger protein 485	ZNF485	Homo sapiens (Human)	441	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NCN2	reviewed	ZBT34_HUMAN	Zinc finger and BTB domain-containing protein 34	ZBTB34 KIAA1993	Homo sapiens (Human)	500	FUNCTION: May be a transcriptional repressor. {ECO:0000269|PubMed:16718364}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16718364}.
Q8NCQ7	reviewed	PRCA1_HUMAN	Protein PROCA1 (Protein interacting with cyclin A1)	PROCA1	Homo sapiens (Human)	364			arachidonic acid secretion [GO:0050482]; phospholipid metabolic process [GO:0006644]		cyclin binding [GO:0030332]; phospholipase A2 activity [GO:0004623]	cyclin binding [GO:0030332]; phospholipase A2 activity [GO:0004623]; arachidonic acid secretion [GO:0050482]; phospholipid metabolic process [GO:0006644]	
Q8NCR3	reviewed	MFI_HUMAN	Protein MFI (Mitochondrial fission factor interactor)	MFI C11orf65	Homo sapiens (Human)	313	FUNCTION: Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network. {ECO:0000250|UniProtKB:Q9D4W2}.		negative regulation of mitochondrial fission [GO:0090258]; negative regulation of protein targeting to mitochondrion [GO:1903215]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]		cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of protein targeting to mitochondrion [GO:1903215]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D4W2}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9D4W2}. Note=Predominantly localizes to the cytosol, with a minor fraction at the outer mitochondrial membrane. {ECO:0000250|UniProtKB:Q9D4W2}.
Q8NCT3	reviewed	MACA2_HUMAN	Putative tyrosine carboxypeptidase MATCAP2 (EC 3.4.17.-)	MATCAP2 KIAA0895	Homo sapiens (Human)	520	FUNCTION: Putative tyrosine carboxypeptidase. {ECO:0000250|UniProtKB:Q68EN5}.		proteolysis [GO:0006508]		carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]	carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; proteolysis [GO:0006508]	
Q8NCU1	reviewed	CC197_HUMAN	Uncharacterized protein CCDC197 (Coiled-coil domain-containing protein 197)	CCDC197 C14orf48 LINC00521	Homo sapiens (Human)	143							
Q8NCV1	reviewed	ADAD2_HUMAN	Adenosine deaminase domain-containing protein 2 (Testis nuclear RNA-binding protein-like)	ADAD2 TENRL	Homo sapiens (Human)	583	FUNCTION: Required for male fertility and normal male germ cell differentiation. {ECO:0000250|UniProtKB:Q9D5P4}.		adenosine to inosine editing [GO:0006382]; RNA processing [GO:0006396]; spermatid development [GO:0007286]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]	double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; tRNA-specific adenosine deaminase activity [GO:0008251]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; tRNA-specific adenosine deaminase activity [GO:0008251]; adenosine to inosine editing [GO:0006382]; RNA processing [GO:0006396]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D5P4}. Cytoplasm {ECO:0000250|UniProtKB:Q9D5P4}. Note=Diffusely cytoplasmic early in pachytene spermatocytes and coalesces into several perinuclear granules by late pachynema. {ECO:0000250|UniProtKB:Q9D5P4}.
Q8NCY6	reviewed	MSD4_HUMAN	Myb/SANT-like DNA-binding domain-containing protein 4 (Myb/SANT-like DNA-binding domain containing 4 with coiled-coils)	MSANTD4 KIAA1826 DC25	Homo sapiens (Human)	345				nucleus [GO:0005634]		nucleus [GO:0005634]	
Q8ND23	reviewed	CARL3_HUMAN	Capping protein, Arp2/3 and myosin-I linker protein 3 (Capping protein regulator and myosin 1 linker protein 3) (Leucine-rich repeat-containing protein 16B)	CARMIL3 C14orf121 LRRC16B	Homo sapiens (Human)	1372			cell migration [GO:0016477]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]	cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; cell migration [GO:0016477]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21102520}. Cell membrane {ECO:0000269|PubMed:26578515}.
Q8ND71	reviewed	GIMA8_HUMAN	GTPase IMAP family member 8 (Immune-associated nucleotide-binding protein 9) (IAN-9) (Protein IanT)	GIMAP8 IAN9 IANT	Homo sapiens (Human)	665	FUNCTION: Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. {ECO:0000250|UniProtKB:Q75N62}.		regulation of T cell apoptotic process [GO:0070232]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]	GTP binding [GO:0005525]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; GTP binding [GO:0005525]; regulation of T cell apoptotic process [GO:0070232]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q75N62}. Golgi apparatus {ECO:0000250|UniProtKB:Q75N62}. Mitochondrion {ECO:0000250|UniProtKB:Q75N62}. Cytoplasm, cytosol {ECO:0000269|PubMed:23454188}.
Q8ND82	reviewed	Z280C_HUMAN	Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633)	ZNF280C SUHW3 ZNF633	Homo sapiens (Human)	737	FUNCTION: May function as a transcription factor.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NDA2	reviewed	HMCN2_HUMAN	Hemicentin-2	HMCN2	Homo sapiens (Human)	5059		MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse organization [GO:0050808]	axon [GO:0030424]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	axon guidance receptor activity [GO:0008046]; calcium ion binding [GO:0005509]	axon [GO:0030424]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; axon guidance receptor activity [GO:0008046]; calcium ion binding [GO:0005509]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:A2AJ76}. Cleavage furrow {ECO:0000250|UniProtKB:A2AJ76}. Note=The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2. {ECO:0000250|UniProtKB:A2AJ76}.
Q8NDB6	reviewed	FA156_HUMAN	Protein FAM156A/FAM156B (Transmembrane protein 29/29B)	FAM156A TMEM29 PP12994 PRO0659; FAM156B TMEM29B	Homo sapiens (Human)	213				membrane [GO:0016020]; nuclear envelope [GO:0005635]	methylated histone binding [GO:0035064]	membrane [GO:0016020]; nuclear envelope [GO:0005635]; methylated histone binding [GO:0035064]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8NDH2	reviewed	CC168_HUMAN	Leucine-rich repeat transmembrane protein CCDC168 (Coiled-coil domain-containing protein 168)	CCDC168 C13orf40	Homo sapiens (Human)	7081				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q8NDV2	reviewed	GPR26_HUMAN	G-protein coupled receptor 26	GPR26	Homo sapiens (Human)	337	FUNCTION: Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. {ECO:0000269|PubMed:17363172}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NDX6	reviewed	ZN740_HUMAN	Zinc finger protein 740 (OriLyt TD-element-binding protein 7)	ZNF740 TB7	Homo sapiens (Human)	193	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NDX9	reviewed	LY65B_HUMAN	Lymphocyte antigen 6 complex locus protein G5b	LY6G5B C6orf19 G5B	Homo sapiens (Human)	201				external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8NE28	reviewed	STKL1_HUMAN	Serine/threonine kinase-like domain-containing protein STKLD1 (Serine/threonine kinase-like domain-containing protein 1) (Sugen kinase 071)	STKLD1 C9orf96 SGK071	Homo sapiens (Human)	680					ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]	
Q8NE62	reviewed	CHDH_HUMAN	Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)	CHDH	Homo sapiens (Human)	594			choline catabolic process [GO:0042426]; glycine betaine biosynthetic process from choline [GO:0019285]	mitochondrial inner membrane [GO:0005743]	choline dehydrogenase activity [GO:0008812]; flavin adenine dinucleotide binding [GO:0050660]	mitochondrial inner membrane [GO:0005743]; choline dehydrogenase activity [GO:0008812]; flavin adenine dinucleotide binding [GO:0050660]; choline catabolic process [GO:0042426]; glycine betaine biosynthetic process from choline [GO:0019285]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
Q8NEB7	reviewed	ACRBP_HUMAN	Acrosin-binding protein (Acrosin-binding protein, 60 kDa form) (Cancer/testis antigen 23) (CT23) (Cancer/testis antigen OY-TES-1) (Proacrosin-binding protein sp32) [Cleaved into: Acrosin-binding protein, mature form (Acrosin-binding protein, 32 kDa form, mature form)]	ACRBP	Homo sapiens (Human)	543	FUNCTION: [Acrosin-binding protein, mature form]: Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation. {ECO:0000250|UniProtKB:Q3V140}.		acrosome assembly [GO:0001675]; fertilization [GO:0009566]; spermatid development [GO:0007286]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; nucleus [GO:0005634]		acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; nucleus [GO:0005634]; acrosome assembly [GO:0001675]; fertilization [GO:0009566]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q29016}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q29016, ECO:0000250|UniProtKB:Q3V140}.
Q8NEF3	reviewed	CC112_HUMAN	Coiled-coil domain-containing protein 112 (Mutated in bladder cancer protein 1)	CCDC112 MBC1	Homo sapiens (Human)	446				centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]		centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26638075}.
Q8NEF9	reviewed	SRFB1_HUMAN	Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP)	SRFBP1	Homo sapiens (Human)	429	FUNCTION: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}.		maturation of SSU-rRNA [GO:0030490]	90S preribosome [GO:0030686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	RNA binding [GO:0003723]	90S preribosome [GO:0030686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RNA binding [GO:0003723]; maturation of SSU-rRNA [GO:0030490]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9CZ91}.
Q8NEG0	reviewed	GAR6_HUMAN	Golgi-associated RAB2 interactor protein 6	GARIN6 FAM71C	Homo sapiens (Human)	241							
Q8NEN0	reviewed	ARMC2_HUMAN	Armadillo repeat-containing protein 2	ARMC2	Homo sapiens (Human)	867	FUNCTION: Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity). {ECO:0000250|UniProtKB:Q3URY6}.		cilium organization [GO:0044782]; sperm axoneme assembly [GO:0007288]			cilium organization [GO:0044782]; sperm axoneme assembly [GO:0007288]	
Q8NEP9	reviewed	ZN555_HUMAN	Zinc finger protein 555	ZNF555	Homo sapiens (Human)	628	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NET1	reviewed	D108B_HUMAN	Beta-defensin 108B (Beta-defensin 8) (BD-8) (DEFB-8) (hBD-8) (Defensin, beta 108) (Defensin, beta 108B)	DEFB108B DEFB108 DEFB8	Homo sapiens (Human)	73	FUNCTION: Has antibacterial activity. {ECO:0000250}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted.
Q8NEW7	reviewed	TMIE_HUMAN	Transmembrane inner ear expressed protein	TMIE	Homo sapiens (Human)	156	FUNCTION: Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain.		inner ear morphogenesis [GO:0042472]; sensory perception of sound [GO:0007605]	membrane [GO:0016020]		membrane [GO:0016020]; inner ear morphogenesis [GO:0042472]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8NEX9	reviewed	DR9C7_HUMAN	Short-chain dehydrogenase/reductase family 9C member 7 (EC 1.1.1.-) (Orphan short-chain dehydrogenase/reductase) (SDR-O) (RDH-S)	SDR9C7 RDHS SDRO	Homo sapiens (Human)	313	FUNCTION: Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity. {ECO:0000269|PubMed:19703561}.		retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]	NAD-retinol dehydrogenase activity [GO:0004745]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; NAD-retinol dehydrogenase activity [GO:0004745]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19703561}. Note=Granular distribution in the whole cell.
Q8NF86	reviewed	PRS33_HUMAN	Serine protease 33 (EC 3.4.21.-) (Serine protease EOS)	PRSS33	Homo sapiens (Human)	280	FUNCTION: Serine protease that has amidolytic activity, cleaving its substrates before Arg residues. {ECO:0000269|PubMed:12795636}.		protein kinase C signaling [GO:0070528]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; protein kinase C signaling [GO:0070528]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q8NFI3	reviewed	ENASE_HUMAN	Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96)	ENGASE	Homo sapiens (Human)	743	FUNCTION: Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol. {ECO:0000269|PubMed:12114544}.		protein folding [GO:0006457]	cytosol [GO:0005829]	hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity [GO:0033925]	cytosol [GO:0005829]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity [GO:0033925]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
Q8NFJ8	reviewed	BHE22_HUMAN	Class E basic helix-loop-helix protein 22 (bHLHe22) (Class B basic helix-loop-helix protein 5) (bHLHb5) (Trinucleotide repeat-containing gene 20 protein)	BHLHE22 BHLHB5 TNRC20	Homo sapiens (Human)	381	FUNCTION: Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal cord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. {ECO:0000250|UniProtKB:Q8C6A8}.		axon development [GO:0061564]; neuron fate commitment [GO:0048663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]; axon development [GO:0061564]; neuron fate commitment [GO:0048663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NFK1	reviewed	CXG3_HUMAN	Gap junction gamma-3 protein (Connexin-30.2) (Cx30.2) (Connexin-31.3) (Cx31.3) (Gap junction epsilon-1 protein)	GJC3 GJE1	Homo sapiens (Human)	279	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.		cell-cell signaling [GO:0007267]; myelination [GO:0042552]; sensory perception of sound [GO:0007605]	connexin complex [GO:0005922]; myelin sheath [GO:0043209]	gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802]	connexin complex [GO:0005922]; myelin sheath [GO:0043209]; gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802]; cell-cell signaling [GO:0007267]; myelination [GO:0042552]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
Q8NFN8	reviewed	GP156_HUMAN	Probable G-protein coupled receptor 156 (G-protein coupled receptor PGR28) (GABAB-related G-protein coupled receptor)	GPR156 GABABL PGR28	Homo sapiens (Human)	814	FUNCTION: Orphan receptor.		gamma-aminobutyric acid signaling pathway [GO:0007214]	G protein-coupled receptor heterodimeric complex [GO:0038039]; plasma membrane [GO:0005886]	G protein-coupled GABA receptor activity [GO:0004965]	G protein-coupled receptor heterodimeric complex [GO:0038039]; plasma membrane [GO:0005886]; G protein-coupled GABA receptor activity [GO:0004965]; gamma-aminobutyric acid signaling pathway [GO:0007214]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NFU0	reviewed	BEST4_HUMAN	Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 2)	BEST4 VMD2L2	Homo sapiens (Human)	473	FUNCTION: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. {ECO:0000269|PubMed:12907679, ECO:0000269|PubMed:18400985}.			chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]	chloride channel activity [GO:0005254]	chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG04	reviewed	S2610_HUMAN	Putative solute carrier family 26 member 10P	SLC26A10P SLC26A10	Homo sapiens (Human)	563	FUNCTION: Chloride/bicarbonate exchanger. {ECO:0000250}.			basolateral plasma membrane [GO:0016323]	antiporter activity [GO:0015297]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116]	basolateral plasma membrane [GO:0016323]; antiporter activity [GO:0015297]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NG48	reviewed	LINES_HUMAN	Protein Lines homolog 1 (Wnt-signaling molecule Lines homolog 1)	LINS1 LINS WINS1	Homo sapiens (Human)	757			cognition [GO:0050890]			cognition [GO:0050890]	
Q8NG68	reviewed	TTL_HUMAN	Tubulin--tyrosine ligase (TTL) (EC 6.3.2.25)	TTL	Homo sapiens (Human)	377	FUNCTION: Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin. {ECO:0000269|PubMed:25908662}.		microtubule cytoskeleton organization [GO:0000226]; positive regulation of mitotic cell cycle [GO:0045931]; post-translational protein modification [GO:0043687]; regulation of axon extension [GO:0030516]; regulation of metaphase plate congression [GO:0090235]	spindle microtubule [GO:0005876]	ATP binding [GO:0005524]; tubulin-tyrosine ligase activity [GO:0004835]	spindle microtubule [GO:0005876]; ATP binding [GO:0005524]; tubulin-tyrosine ligase activity [GO:0004835]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of mitotic cell cycle [GO:0045931]; post-translational protein modification [GO:0043687]; regulation of axon extension [GO:0030516]; regulation of metaphase plate congression [GO:0090235]	
Q8NGA0	reviewed	OR7G1_HUMAN	Olfactory receptor 7G1 (Olfactory receptor 19-15) (OR19-15) (Olfactory receptor OR19-8)	OR7G1 OR7G1P	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGA4	reviewed	G32P1_HUMAN	Putative G-protein coupled receptor GPR32P1 (G-protein coupled 32 pseudogene) (G-protein coupled 32 pseudogene 1) (G-protein coupled receptor GPCR39) (hGPCR39)	GPR32P1	Homo sapiens (Human)	272	FUNCTION: Orphan receptor.		complement receptor mediated signaling pathway [GO:0002430]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	plasma membrane [GO:0005886]	complement receptor activity [GO:0004875]; N-formyl peptide receptor activity [GO:0004982]	plasma membrane [GO:0005886]; complement receptor activity [GO:0004875]; N-formyl peptide receptor activity [GO:0004982]; complement receptor mediated signaling pathway [GO:0002430]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGC8	reviewed	O11H7_HUMAN	Olfactory receptor 11H7 (Olfactory receptor OR14-32)	OR11H7 OR11H7P	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. Activated by isovaleric acid. {ECO:0000269|PubMed:17973576}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGD0	reviewed	OR4M1_HUMAN	Olfactory receptor 4M1 (Olfactory receptor OR14-7)	OR4M1	Homo sapiens (Human)	313	FUNCTION: Olfactory receptor that acts as a receptor of Asprosin hormone, potentially at the surface of hepatocytes and may help to promote hepatocyte glucose release. {ECO:0000269|PubMed:31230984}.	MISCELLANEOUS: The human olfactory receptor 4M1 (Q8NGD0) is not the one to one ortholog of mouse Or4m1 (Q8VFT4). {ECO:0000305}.		plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31230984}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU363047}.
Q8NGE3	reviewed	O10P1_HUMAN	Olfactory receptor 10P1 (Olfactory receptor 10P2) (Olfactory receptor 10P3) (Olfactory receptor OR12-7)	OR10P1 OR10P1P OR10P2P OR10P3P	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGG2	reviewed	OR5T2_HUMAN	Olfactory receptor 5T2 (Olfactory receptor OR11-177)	OR5T2	Homo sapiens (Human)	359	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGH7	reviewed	O52L1_HUMAN	Olfactory receptor 52L1 (Olfactory receptor OR11-50)	OR52L1	Homo sapiens (Human)	329	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGI2	reviewed	O52N4_HUMAN	Olfactory receptor 52N4 (Olfactory receptor OR11-64)	OR52N4	Homo sapiens (Human)	321	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGI8	reviewed	O5AN1_HUMAN	Olfactory receptor 5AN1 (Olfactory receptor OR11-244)	OR5AN1	Homo sapiens (Human)	311	FUNCTION: Odorant receptor involved in the detection of muscone, cyclopentadecanone, cyclopentadecanol, and omega-pentadecalactone (PubMed:24361078, PubMed:25901328). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Probable). {ECO:0000269|PubMed:24361078, ECO:0000269|PubMed:25901328, ECO:0000305}.		detection of chemical stimulus involved in sensory perception [GO:0050907]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception [GO:0050907]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:24361078, ECO:0000305|PubMed:25901328}; Multi-pass membrane protein {ECO:0000255}.
Q8NGJ2	reviewed	O52H1_HUMAN	Olfactory receptor 52H1 (Olfactory receptor OR11-45)	OR52H1	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGK2	reviewed	O52B4_HUMAN	Olfactory receptor 52B4 (Olfactory receptor OR11-3)	OR52B4	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		cognition [GO:0050890]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; cognition [GO:0050890]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGM9	reviewed	OR8D4_HUMAN	Olfactory receptor 8D4 (Olfactory receptor OR11-275)	OR8D4	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGN3	reviewed	O10G4_HUMAN	Olfactory receptor 10G4 (Olfactory receptor OR11-278)	OR10G4	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGQ1	reviewed	OR9G4_HUMAN	Olfactory receptor 9G4 (Olfactory receptor OR11-216)	OR9G4	Homo sapiens (Human)	327	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGR2	reviewed	OR1L6_HUMAN	Olfactory receptor 1L6 (Olfactory receptor 1L7) (Olfactory receptor OR9-30)	OR1L6 OR1L7	Homo sapiens (Human)	347	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGR6	reviewed	OR1B1_HUMAN	Olfactory receptor 1B1 (Olfactory receptor 9-B) (OR9-B) (Olfactory receptor OR9-26)	OR1B1	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGS2	reviewed	OR1J2_HUMAN	Olfactory receptor 1J2 (HSA5) (HTPCRX15) (OST044) (Olfactory receptor 1J3) (Olfactory receptor 1J5) (Olfactory receptor OR9-19)	OR1J2 OR1J3 OR1J5	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGS8	reviewed	O13C5_HUMAN	Olfactory receptor 13C5 (Olfactory receptor OR9-11)	OR13C5	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGT0	reviewed	O13C9_HUMAN	Olfactory receptor 13C9 (Olfactory receptor OR9-13)	OR13C9	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGV6	reviewed	OR5H6_HUMAN	Olfactory receptor 5H6 (Olfactory receptor OR3-11)	OR5H6	Homo sapiens (Human)	325	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGW1	reviewed	OR6B3_HUMAN	Olfactory receptor 6B3 (Olfactory receptor OR2-2)	OR6B3 OR6B3P	Homo sapiens (Human)	331	FUNCTION: Odorant receptor. {ECO:0000305}.			cytosol [GO:0005829]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGW6	reviewed	OR6K6_HUMAN	Olfactory receptor 6K6 (Olfactory receptor OR1-21)	OR6K6	Homo sapiens (Human)	343	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGX3	reviewed	O10T2_HUMAN	Olfactory receptor 10T2 (Olfactory receptor OR1-3)	OR10T2	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGY0	reviewed	O10X1_HUMAN	Olfactory receptor 10X1 (Olfactory receptor OR1-14)	OR10X1 OR10X1P	Homo sapiens (Human)	326	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGY3	reviewed	OR6K3_HUMAN	Olfactory receptor 6K3 (Olfactory receptor OR1-18)	OR6K3	Homo sapiens (Human)	331	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH10	reviewed	OR8U1_HUMAN	Olfactory receptor 8U1	OR8U1	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH19	reviewed	O10AG_HUMAN	Olfactory receptor 10AG1 (Olfactory receptor OR11-160)	OR10AG1	Homo sapiens (Human)	301	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH43	reviewed	OR4L1_HUMAN	Olfactory receptor 4L1 (Olfactory receptor 4L2) (Olfactory receptor OR14-28)	OR4L1 OR4L2P	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH48	reviewed	OR5B3_HUMAN	Olfactory receptor 5B3 (Olfactory receptor 5B13) (Olfactory receptor OR11-239)	OR5B3 OR5B13	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH59	reviewed	O51Q1_HUMAN	Olfactory receptor 51Q1	OR51Q1	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH69	reviewed	OR5W2_HUMAN	Olfactory receptor 5W2 (Olfactory receptor 5W3) (Olfactory receptor OR11-155)	OR5W2 OR5W2P OR5W3P	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH85	reviewed	OR5R1_HUMAN	Olfactory receptor 8U3 (Olfactory receptor 5R1) (Olfactory receptor OR11-185)	OR8U3 OR5R1 OR5R1P	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH87	reviewed	OR9G1_HUMAN	Olfactory receptor 9G1 (Olfactory receptor 9G5) (Olfactory receptor OR11-114)	OR9G1 OR9G5	Homo sapiens (Human)	305	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH92	reviewed	OR1S1_HUMAN	Olfactory receptor 1S1 (Olfactory receptor OR11-232)	OR1S1	Homo sapiens (Human)	325	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH94	reviewed	OR1L1_HUMAN	Olfactory receptor 1L1 (Olfactory receptor 1L2) (Olfactory receptor 9-C) (OR9-C) (Olfactory receptor OR9-27)	OR1L1 OR1L2	Homo sapiens (Human)	360	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHC8	reviewed	OR2T6_HUMAN	Olfactory receptor 2T6 (OST703) (Olfactory receptor 2T9)	OR2T6 OR2T6P OR2T9	Homo sapiens (Human)	308	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHK3	reviewed	KI2LB_HUMAN	Killer cell immunoglobulin-like receptor 2DL5B (CD158 antigen-like family member F2) (Killer cell immunoglobulin-like receptor 2DLX) (CD antigen CD158f2)	KIR2DL5B CD158F CD158F2 KIR2DL5 KIR2DLX	Homo sapiens (Human)	375	FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.			plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q8NHM4	reviewed	TRY6_HUMAN	Putative trypsin-6 (EC 3.4.21.4) (Serine protease 3 pseudogene 2) (Trypsinogen C)	PRSS3P2 T6 TRY6	Homo sapiens (Human)	247	FUNCTION: May regulate cell migration. {ECO:0000269|PubMed:15313892}.		endothelial cell migration [GO:0043542]; proteolysis [GO:0006508]	extracellular space [GO:0005615]	metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]	extracellular space [GO:0005615]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; endothelial cell migration [GO:0043542]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8NHP7	reviewed	EXD1_HUMAN	piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1)	EXD1 EXDL1	Homo sapiens (Human)	514	FUNCTION: RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity). {ECO:0000250|UniProtKB:H9IUR0, ECO:0000250|UniProtKB:Q8CDF7}.		meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; regulatory ncRNA-mediated gene silencing [GO:0031047]	P granule [GO:0043186]; PET complex [GO:1990923]	protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]	P granule [GO:0043186]; PET complex [GO:1990923]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; regulatory ncRNA-mediated gene silencing [GO:0031047]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:H9IUR0}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:H9IUR0}.
Q8NHQ8	reviewed	RASF8_HUMAN	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1)	RASSF8 C12orf2	Homo sapiens (Human)	419			signal transduction [GO:0007165]			signal transduction [GO:0007165]	
Q8NHR7	reviewed	TERB2_HUMAN	Telomere repeats-binding bouquet formation protein 2	TERB2 C15orf43	Homo sapiens (Human)	220	FUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. {ECO:0000250|UniProtKB:Q9D494}.		double-strand break repair involved in meiotic recombination [GO:1990918]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	chromosome, telomeric region [GO:0000781]; nuclear inner membrane [GO:0005637]		chromosome, telomeric region [GO:0000781]; nuclear inner membrane [GO:0005637]; double-strand break repair involved in meiotic recombination [GO:1990918]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Chromosome, telomere {ECO:0000250|UniProtKB:Q9D494}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q9D494}. Note=Localizes to telomeres throughout meiotic prophase I and disappears in metaphase I. In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9D494}.
Q8NHU2	reviewed	CFA61_HUMAN	Cilia- and flagella-associated protein 61	CFAP61 C20orf26	Homo sapiens (Human)	1237	FUNCTION: May regulate cilium motility through its role in the assembly of the axonemal radial spokes. {ECO:0000250|UniProtKB:A8IF44, ECO:0000250|UniProtKB:Q23F13}.	MISCELLANEOUS: [Isoform 5]: Created from a fragment entry and may await further characterization. {ECO:0000305}.	cilium movement [GO:0003341]; cilium organization [GO:0044782]	axoneme [GO:0005930]; motile cilium [GO:0031514]		axoneme [GO:0005930]; motile cilium [GO:0031514]; cilium movement [GO:0003341]; cilium organization [GO:0044782]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A8IF44}.
Q8NHY6	reviewed	ZFP28_HUMAN	Zinc finger protein 28 homolog (Zfp-28) (Krueppel-like zinc finger factor X6)	ZFP28 KIAA1431	Homo sapiens (Human)	868	FUNCTION: May be involved in transcriptional regulation. May have a role in embryonic development.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NI29	reviewed	FBX27_HUMAN	F-box only protein 27 (F-box/G-domain protein 5)	FBXO27 FBG5 FBX27	Homo sapiens (Human)	283	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. {ECO:0000269|PubMed:18203720}.		glycoprotein catabolic process [GO:0006516]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; glycoprotein catabolic process [GO:0006516]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]	
Q8NI32	reviewed	LPD6B_HUMAN	Ly6/PLAUR domain-containing protein 6B	LYPD6B	Homo sapiens (Human)	183	FUNCTION: Likely acts as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (PubMed:34631692, PubMed:26586467). In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner (PubMed:26586467). Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence (PubMed:26586467). However, according to another report in vitro it can weakly inhibits alpha-7 nAChRs (PubMed:34631692). {ECO:0000269|PubMed:26586467, ECO:0000269|PubMed:34631692}.			extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	acetylcholine receptor regulator activity [GO:0030548]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; acetylcholine receptor regulator activity [GO:0030548]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Q8NI99	reviewed	ANGL6_HUMAN	Angiopoietin-related protein 6 (Angiopoietin-like protein 6) (Angiopoietin-related growth factor) (Angiopoietin-related protein 5)	ANGPTL6 AGF ARP5 UNQ152/PRO178	Homo sapiens (Human)	470	FUNCTION: May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.		angiogenesis [GO:0001525]; cell differentiation [GO:0030154]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; secretory granule [GO:0030141]	signaling receptor binding [GO:0005102]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; signaling receptor binding [GO:0005102]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8TAA3	reviewed	PSMA8_HUMAN	Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like)	PSMA8 PSMA7L	Homo sapiens (Human)	256	FUNCTION: Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. {ECO:0000250|UniProtKB:Q9CWH6}.		cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; proteasomal protein catabolic process [GO:0010498]; regulation of meiosis I [GO:0060631]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; proteasome core complex, alpha-subunit complex [GO:0019773]; spermatoproteasome complex [GO:1990111]		cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; proteasome core complex, alpha-subunit complex [GO:0019773]; spermatoproteasome complex [GO:1990111]; cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; proteasomal protein catabolic process [GO:0010498]; regulation of meiosis I [GO:0060631]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9CWH6}. Note=Localizes to the central region of the synaptonemal complex. {ECO:0000250|UniProtKB:Q9CWH6}.
Q8TAA5	reviewed	GRPE2_HUMAN	GrpE protein homolog 2, mitochondrial (Mt-GrpE#2)	GRPEL2	Homo sapiens (Human)	225	FUNCTION: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). {ECO:0000250}.		intracellular protein transport [GO:0006886]; protein folding [GO:0006457]; protein import into mitochondrial matrix [GO:0030150]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	adenyl-nucleotide exchange factor activity [GO:0000774]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; adenyl-nucleotide exchange factor activity [GO:0000774]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; intracellular protein transport [GO:0006886]; protein folding [GO:0006457]; protein import into mitochondrial matrix [GO:0030150]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
Q8TAE6	reviewed	PP14C_HUMAN	Protein phosphatase 1 regulatory subunit 14C (Kinase-enhanced PP1 inhibitor) (PKC-potentiated PP1 inhibitory protein) (Serologically defined breast cancer antigen NY-BR-81)	PPP1R14C KEPI	Homo sapiens (Human)	165	FUNCTION: Inhibitor of the PP1 regulatory subunit PPP1CA.		regulation of phosphorylation [GO:0042325]	cytoplasm [GO:0005737]; membrane [GO:0016020]	protein serine/threonine phosphatase inhibitor activity [GO:0004865]	cytoplasm [GO:0005737]; membrane [GO:0016020]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; regulation of phosphorylation [GO:0042325]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q8TAF7	reviewed	ZN461_HUMAN	Zinc finger protein 461 (Gonadotropin-inducible ovary transcription repressor 1) (GIOT-1)	ZNF461 GIOT1	Homo sapiens (Human)	563	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TAG6	reviewed	VEXIN_HUMAN	Vexin	VXN C8orf46	Homo sapiens (Human)	207	FUNCTION: Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis. {ECO:0000250|UniProtKB:Q8BG31}.		neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]	nucleus [GO:0005634]; plasma membrane [GO:0005886]		nucleus [GO:0005634]; plasma membrane [GO:0005886]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BG31}. Nucleus {ECO:0000250|UniProtKB:Q8BG31}. Note=Nuclear localization is essential for its function in neurogenesis. {ECO:0000250|UniProtKB:Q8BG31}.
Q8TAK5	reviewed	GABP2_HUMAN	GA-binding protein subunit beta-2 (GABP subunit beta-2) (GABPB-2)	GABPB2	Homo sapiens (Human)	448	FUNCTION: May function as transcription factor capable of interacting with purine rich repeats (GA repeats). {ECO:0000250}.		positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleus [GO:0005634]	identical protein binding [GO:0042802]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]; identical protein binding [GO:0042802]; transcription cis-regulatory region binding [GO:0000976]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8TAL6	reviewed	FIBIN_HUMAN	Fin bud initiation factor homolog	FIBIN PSEC0235	Homo sapiens (Human)	211			protein kinase C signaling [GO:0070528]; response to dexamethasone [GO:0071548]; response to manganese ion [GO:0010042]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]	protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; protein homodimerization activity [GO:0042803]; protein kinase C signaling [GO:0070528]; response to dexamethasone [GO:0071548]; response to manganese ion [GO:0010042]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Golgi apparatus {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:21615908}.
Q8TAQ5	reviewed	ZN420_HUMAN	Zinc finger protein 420	ZNF420	Homo sapiens (Human)	688	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TAQ9	reviewed	SUN3_HUMAN	SUN domain-containing protein 3 (Sad1/unc-84 domain-containing protein 1)	SUN3 SUNC1	Homo sapiens (Human)	357	FUNCTION: As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q5SS91}.			meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]	protein-membrane adaptor activity [GO:0043495]	meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; protein-membrane adaptor activity [GO:0043495]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000250|UniProtKB:Q5SS91}. Nucleus inner membrane {ECO:0000305}.
Q8TAV4	reviewed	STML3_HUMAN	Stomatin-like protein 3 (SLP-3)	STOML3	Homo sapiens (Human)	291	FUNCTION: Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations. {ECO:0000250|UniProtKB:Q6PE84}.		signal transduction [GO:0007165]	cilium [GO:0005929]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]		cilium [GO:0005929]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6PE84}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q6PE84}. Note=Detected in lipid rafts. {ECO:0000250|UniProtKB:Q6PE84}.
Q8TB03	reviewed	CX038_HUMAN	Uncharacterized protein CXorf38	CXorf38	Homo sapiens (Human)	319							
Q8TB52	reviewed	FBX30_HUMAN	F-box only protein 30	FBXO30 FBX30	Homo sapiens (Human)	745	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. {ECO:0000250}.		protein ubiquitination [GO:0016567]	cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]	
Q8TB96	reviewed	TIP_HUMAN	T-cell immunomodulatory protein (Protein TIP) (Integrin-alpha FG-GAP repeat-containing protein 1) (Linkin)	ITFG1 LNKN-1 TIP CDA08	Homo sapiens (Human)	612	FUNCTION: Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity). {ECO:0000250}.			extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]		extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8TBB5	reviewed	KLDC4_HUMAN	Kelch domain-containing protein 4	KLHDC4	Homo sapiens (Human)	520							
Q8TBF4	reviewed	ZCRB1_HUMAN	Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) (U11/U12 snRNP 31 kDa protein) (U11/U12-31K)	ZCRB1	Homo sapiens (Human)	217			mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:16959469}.
Q8TBH0	reviewed	ARRD2_HUMAN	Arrestin domain-containing protein 2	ARRDC2 PP2703	Homo sapiens (Human)	407			protein transport [GO:0015031]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; protein transport [GO:0015031]	
Q8TBP0	reviewed	TBC16_HUMAN	TBC1 domain family member 16	TBC1D16	Homo sapiens (Human)	767	FUNCTION: May act as a GTPase-activating protein for Rab family protein(s).		regulation of receptor recycling [GO:0001919]	cytosol [GO:0005829]; early endosome [GO:0005769]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; early endosome [GO:0005769]; GTPase activator activity [GO:0005096]; regulation of receptor recycling [GO:0001919]	
Q8TBQ9	reviewed	KISHA_HUMAN	Protein kish-A (Transmembrane protein 167) (Transmembrane protein 167A)	TMEM167A TMEM167	Homo sapiens (Human)	72	FUNCTION: Involved in the early part of the secretory pathway. {ECO:0000269|PubMed:19942856}.		constitutive secretory pathway [GO:0045054]; intracellular transport [GO:0046907]; protein secretion [GO:0009306]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]		Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; constitutive secretory pathway [GO:0045054]; intracellular transport [GO:0046907]; protein secretion [GO:0009306]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19942856}; Single-pass type I membrane protein {ECO:0000269|PubMed:19942856}.
Q8TBZ0	reviewed	CC110_HUMAN	Coiled-coil domain-containing protein 110 (Cancer/testis antigen 52) (CT52) (Cancer/testis antigen KM-HN-1)	CCDC110 KMHN1	Homo sapiens (Human)	833				cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15447989}.
Q8TBZ5	reviewed	ZN502_HUMAN	Zinc finger protein 502	ZNF502	Homo sapiens (Human)	544	FUNCTION: May be involved in transcriptional regulation.		positive regulation by host of viral process [GO:0044794]; regulation of DNA-templated transcription [GO:0006355]; viral release from host cell [GO:0019076]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation by host of viral process [GO:0044794]; regulation of DNA-templated transcription [GO:0006355]; viral release from host cell [GO:0019076]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TC21	reviewed	ZN596_HUMAN	Zinc finger protein 596	ZNF596	Homo sapiens (Human)	504	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TC56	reviewed	GAR3_HUMAN	Golgi-associated RAB2 interactor protein 3	GARIN3 FAM71B HSD-51 HSD51	Homo sapiens (Human)	605	FUNCTION: May be involved in RNA biogenesis. {ECO:0000269|PubMed:17103222}.			Cajal body [GO:0015030]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]		Cajal body [GO:0015030]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q5STT6}. Nucleus, Cajal body {ECO:0000269|PubMed:17103222}.
Q8TC76	reviewed	F110B_HUMAN	Protein FAM110B	FAM110B C8orf72	Homo sapiens (Human)	370	FUNCTION: May be involved in tumor progression.			cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17499476}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17499476}.
Q8TCB6	reviewed	O51E1_HUMAN	Olfactory receptor 51E1 (D-GPCR) (G-protein coupled receptor 164) (Olfactory receptor 52A3) (Prostate-overexpressed G protein-coupled receptor) (Prostate-specific G protein-coupled receptor 2)	OR51E1 GPR164 OR51E1P OR52A3P POGR PSGR2	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15313197}; Multi-pass membrane protein {ECO:0000269|PubMed:15313197}.
Q8TCC3	reviewed	RM30_HUMAN	Large ribosomal subunit protein uL30m (39S ribosomal protein L28, mitochondrial) (L28mt) (MRP-L28) (39S ribosomal protein L30, mitochondrial) (L30mt) (MRP-L30)	MRPL30 MRPL28 RPML28 HSPC249	Homo sapiens (Human)	161			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q8TCD1	reviewed	CR032_HUMAN	UPF0729 protein C18orf32 (Putative NF-kappa-B-activating protein 200)	C18orf32	Homo sapiens (Human)	76	FUNCTION: May activate the NF-kappa-B signaling pathway. {ECO:0000269|PubMed:12761501}.		positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]		endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:29275994, ECO:0000269|PubMed:35107634}. Lipid droplet {ECO:0000269|PubMed:29275994}.
Q8TCD6	reviewed	PHOP2_HUMAN	Pyridoxal phosphate phosphatase PHOSPHO2 (EC 3.1.3.74)	PHOSPHO2	Homo sapiens (Human)	241	FUNCTION: Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate. {ECO:0000269|PubMed:16054448}.				metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; pyridoxal phosphatase activity [GO:0033883]	metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; pyridoxal phosphatase activity [GO:0033883]	
Q8TCV5	reviewed	WFDC5_HUMAN	WAP four-disulfide core domain protein 5 (Putative protease inhibitor WAP1) (p53-responsive gene 5 protein)	WFDC5 PRG5 WAP1 UNQ3036/PRO9842	Homo sapiens (Human)	224	FUNCTION: Putative acid-stable proteinase inhibitor.		antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8TCW7	reviewed	ZPLD1_HUMAN	Zona pellucida-like domain-containing protein 1 (ZP domain-containing protein 1) (Cupulin) [Cleaved into: Zona pellucida-like domain-containing protein 1, secreted form]	ZPLD1	Homo sapiens (Human)	415	FUNCTION: Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ. {ECO:0000250|UniProtKB:C0H9B6}.		vestibular reflex [GO:0060005]	cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; extracellular space [GO:0005615]		cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; extracellular space [GO:0005615]; vestibular reflex [GO:0060005]	SUBCELLULAR LOCATION: [Zona pellucida-like domain-containing protein 1]: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:C0H9B6}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Zona pellucida-like domain-containing protein 1, secreted form]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:C0H9B6}.
Q8TCW9	reviewed	PKR1_HUMAN	Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (GPR73a)	PROKR1 GPR73 PKR1	Homo sapiens (Human)	393	FUNCTION: Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy. {ECO:0000269|PubMed:18339712}.		circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	neuropeptide Y receptor activity [GO:0004983]	plasma membrane [GO:0005886]; neuropeptide Y receptor activity [GO:0004983]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8TD20	reviewed	GTR12_HUMAN	Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12)	SLC2A12 GLUT12	Homo sapiens (Human)	617	FUNCTION: Insulin-independent facilitative glucose transporter. {ECO:0000250|UniProtKB:Q8BFW9}.		circulatory system development [GO:0072359]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]	endomembrane system [GO:0012505]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	D-glucose transmembrane transporter activity [GO:0055056]; glucose transmembrane transporter activity [GO:0005355]; symporter activity [GO:0015293]	endomembrane system [GO:0012505]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; D-glucose transmembrane transporter activity [GO:0055056]; glucose transmembrane transporter activity [GO:0005355]; symporter activity [GO:0015293]; circulatory system development [GO:0072359]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BFW9}; Multi-pass membrane protein {ECO:0000255}. Endomembrane system {ECO:0000250|UniProtKB:Q5J316}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11832379}. Note=Localizes primarily perinuclear region in the absence of insulin. {ECO:0000269|PubMed:11832379}.
Q8TD94	reviewed	KLF14_HUMAN	Krueppel-like factor 14 (Basic transcription element-binding protein 5) (BTE-binding protein 5) (Transcription factor BTEB5)	KLF14 BTEB5	Homo sapiens (Human)	323			positive regulation of sphingolipid mediated signaling pathway [GO:1902070]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; positive regulation of sphingolipid mediated signaling pathway [GO:1902070]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8TDE3	reviewed	RNAS8_HUMAN	Ribonuclease 8 (RNase 8) (EC 3.1.27.-)	RNASE8	Homo sapiens (Human)	154	FUNCTION: Has a low ribonuclease activity.		antifungal innate immune response [GO:0061760]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]	extracellular space [GO:0005615]	nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540]	extracellular space [GO:0005615]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540]; antifungal innate immune response [GO:0061760]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8TDM0	reviewed	BCAS4_HUMAN	Breast carcinoma-amplified sequence 4	BCAS4	Homo sapiens (Human)	211				BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737]		BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8TDM5	reviewed	SACA4_HUMAN	Sperm acrosome membrane-associated protein 4 (Sperm acrosomal membrane-associated protein 14)	SPACA4 SAMP14 UNQ3046/PRO9862	Homo sapiens (Human)	124	FUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. {ECO:0000269|PubMed:12788941}.		cell adhesion [GO:0007155]; sperm-egg recognition [GO:0035036]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; cell adhesion [GO:0007155]; sperm-egg recognition [GO:0035036]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12788941}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12788941}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:12788941}. Note=Expressed in acrosomal matrix and outer and inner acrosomal membranes. {ECO:0000269|PubMed:12788941}.
Q8TDN6	reviewed	BRX1_HUMAN	Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2)	BRIX1 BRIX BXDC2	Homo sapiens (Human)	353	FUNCTION: Required for biogenesis of the 60S ribosomal subunit.		ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]	chromosome [GO:0005694]; nucleolus [GO:0005730]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]	chromosome [GO:0005694]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus.
Q8TDV2	reviewed	GP148_HUMAN	Probable G-protein coupled receptor 148 (Brain and testis restricted GPCR) (G-protein coupled receptor PGR6)	GPR148 BTR PGR6	Homo sapiens (Human)	347	FUNCTION: Orphan receptor.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8TDV5	reviewed	GP119_HUMAN	Glucose-dependent insulinotropic receptor (G-protein coupled receptor 119)	GPR119	Homo sapiens (Human)	335	FUNCTION: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. {ECO:0000269|PubMed:16517404}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; insulin secretion [GO:0030073]; regulation of metabolic process [GO:0019222]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled receptor activity [GO:0004930]; phosphatidylcholine binding [GO:0031210]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled receptor activity [GO:0004930]; phosphatidylcholine binding [GO:0031210]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; insulin secretion [GO:0030073]; regulation of metabolic process [GO:0019222]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8TDW4	reviewed	ST7L_HUMAN	Suppressor of tumorigenicity 7 protein-like (ST7-related protein)	ST7L ST7R	Homo sapiens (Human)	575			negative regulation of cell growth [GO:0030308]	membrane [GO:0016020]		membrane [GO:0016020]; negative regulation of cell growth [GO:0030308]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8TDY8	reviewed	IGDC4_HUMAN	Immunoglobulin superfamily DCC subclass member 4 (Neighbor of punc e11) (Protein DDM36) (hDDM36)	IGDCC4 DDM36 KIAA1628 NOPE	Homo sapiens (Human)	1250			cell-cell adhesion [GO:0098609]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cell-cell adhesion [GO:0098609]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8TE69	reviewed	EOLA1_HUMAN	Protein EOLA1 (Endothelial-overexpressed lipopolysaccharide-associated factor 1) (Endothelium and lymphocyte associated ASCH domain 1)	EOLA1 CXorf40 CXorf40A	Homo sapiens (Human)	158	FUNCTION: May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expression (PubMed:24916366). {ECO:0000269|PubMed:24916366}.		regulation of gene expression [GO:0010468]; regulation of interleukin-6 production [GO:0032675]			regulation of gene expression [GO:0010468]; regulation of interleukin-6 production [GO:0032675]	
Q8TET4	reviewed	GANC_HUMAN	Neutral alpha-glucosidase C (EC 3.2.1.20)	GANC	Homo sapiens (Human)	914	FUNCTION: Has alpha-glucosidase activity. {ECO:0000269|PubMed:12370436}.		N-glycan processing [GO:0006491]		alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]; maltose alpha-glucosidase activity [GO:0032450]	alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]; maltose alpha-glucosidase activity [GO:0032450]; N-glycan processing [GO:0006491]	
Q8TF05	reviewed	PP4R1_HUMAN	Serine/threonine-protein phosphatase 4 regulatory subunit 1	PPP4R1 MEG1 PP4R1	Homo sapiens (Human)	950	FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. {ECO:0000269|PubMed:15805470}.		protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	protein phosphatase 4 complex [GO:0030289]	protein phosphatase regulator activity [GO:0019888]	protein phosphatase 4 complex [GO:0030289]; protein phosphatase regulator activity [GO:0019888]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	
Q8TF21	reviewed	ANR24_HUMAN	Ankyrin repeat domain-containing protein 24	ANKRD24 KIAA1981	Homo sapiens (Human)	1146	FUNCTION: Componement of the stereocilia rootlet in hair cells of inner ear. Bridges the apical plasma membrane with the lower rootlet and maintains normal distribution of TRIOBP, thereby reinforcing stereocilia insertion points and organizing rootlets for hearing with long-term resilience. {ECO:0000250|UniProtKB:Q80VM7}.		auditory receptor cell stereocilium organization [GO:0060088]; sensory perception of sound [GO:0007605]	plasma membrane [GO:0005886]; stereocilium [GO:0032420]	actin binding [GO:0003779]	plasma membrane [GO:0005886]; stereocilium [GO:0032420]; actin binding [GO:0003779]; auditory receptor cell stereocilium organization [GO:0060088]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80VM7}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q80VM7}. Note=Localizes to hair cell stereocilia rootlets. Concentrated to the stereolocilia insertion point. {ECO:0000250|UniProtKB:Q80VM7}.
Q8TF39	reviewed	ZN483_HUMAN	Zinc finger protein 483 (Zinc finger protein with KRAB and SCAN domains 16)	ZNF483 KIAA1962 ZKSCAN16	Homo sapiens (Human)	744	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TF45	reviewed	ZN418_HUMAN	Zinc finger protein 418	ZNF418 KIAA1956	Homo sapiens (Human)	676	FUNCTION: Transcriptional repressor (PubMed:18084723). May play a role as regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway (By similarity). {ECO:0000250|UniProtKB:Q8BFS8, ECO:0000269|PubMed:18084723}.		lysosomal microautophagy [GO:0016237]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; lysosomal microautophagy [GO:0016237]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18084723}.
Q8TF64	reviewed	GIPC3_HUMAN	PDZ domain-containing protein GIPC3	GIPC3 C19orf64	Homo sapiens (Human)	312	FUNCTION: Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion. {ECO:0000250}.						
Q8TF68	reviewed	ZN384_HUMAN	Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein)	ZNF384 CAGH1 CIZ NMP4 TNRC1	Homo sapiens (Human)	577	FUNCTION: Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity). {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8WUA2	reviewed	PPIL4_HUMAN	Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4)	PPIL4	Homo sapiens (Human)	492	FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8WUF8	reviewed	F172A_HUMAN	Cotranscriptional regulator FAM172A (Protein FAM172A)	FAM172A C5orf21	Homo sapiens (Human)	416	FUNCTION: Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity. {ECO:0000250|UniProtKB:Q3TNH5}.		mRNA processing [GO:0006397]; neural crest cell development [GO:0014032]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; RNA splicing [GO:0008380]	endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]		endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; mRNA processing [GO:0006397]; neural crest cell development [GO:0014032]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3TNH5}. Cytoplasm {ECO:0000250|UniProtKB:Q3TNH5}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q3TNH5}.
Q8WUH1	reviewed	CHUR_HUMAN	Protein Churchill	CHURC1 C14orf52 CHCH My015	Homo sapiens (Human)	112	FUNCTION: Transcriptional activator that mediates FGF signaling during neural development (By similarity). Plays a role in the regulation of cell movement (By similarity). {ECO:0000250|UniProtKB:Q5U3N7, ECO:0000250|UniProtKB:Q9DFZ3}.; FUNCTION: [Isoform 4]: Does not bind DNA by itself. {ECO:0000269|PubMed:17610897}.		fibroblast growth factor receptor signaling pathway [GO:0008543]; positive regulation of DNA-templated transcription [GO:0045893]		zinc ion binding [GO:0008270]	zinc ion binding [GO:0008270]; fibroblast growth factor receptor signaling pathway [GO:0008543]; positive regulation of DNA-templated transcription [GO:0045893]	
Q8WUJ1	reviewed	NEUFC_HUMAN	Neuferricin (Cytochrome b5 domain-containing protein 2)	CYB5D2	Homo sapiens (Human)	264	FUNCTION: Heme-binding protein which promotes neuronal but not astrocyte differentiation. {ECO:0000250}.	MISCELLANEOUS: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). {ECO:0000303|PubMed:23763432, ECO:0000303|PubMed:28396637}.	neuron differentiation [GO:0030182]; positive regulation of neuron differentiation [GO:0045666]	endomembrane system [GO:0012505]; extracellular region [GO:0005576]; membrane [GO:0016020]	heme binding [GO:0020037]	endomembrane system [GO:0012505]; extracellular region [GO:0005576]; membrane [GO:0016020]; heme binding [GO:0020037]; neuron differentiation [GO:0030182]; positive regulation of neuron differentiation [GO:0045666]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q8WUN7	reviewed	UBTD2_HUMAN	Ubiquitin domain-containing protein 2 (Dendritic cell-derived ubiquitin-like protein) (DC-UbP) (Ubiquitin-like protein SB72)	UBTD2 DCUBP SB72	Homo sapiens (Human)	234				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12507522}.
Q8WUT4	reviewed	LRRN4_HUMAN	Leucine-rich repeat neuronal protein 4 (Neuronal leucine-rich repeat protein 4) (NLRR-4)	LRRN4 C20orf75	Homo sapiens (Human)	740	FUNCTION: May play an important role in hippocampus-dependent long-lasting memory. {ECO:0000250}.		long-term memory [GO:0007616]; visual learning [GO:0008542]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]		extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; long-term memory [GO:0007616]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8WUX2	reviewed	CHAC2_HUMAN	Glutathione-specific gamma-glutamylcyclotransferase 2 (Gamma-GCG 2) (EC 4.3.2.7) (Cation transport regulator-like protein 2)	CHAC2	Homo sapiens (Human)	184	FUNCTION: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. {ECO:0000269|PubMed:27913623}.		glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	gamma-glutamylcyclotransferase activity [GO:0003839]; glutathione specific gamma-glutamylcyclotransferase activity [GO:0061928]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; gamma-glutamylcyclotransferase activity [GO:0003839]; glutathione specific gamma-glutamylcyclotransferase activity [GO:0061928]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:27913623}.
Q8WUZ0	reviewed	BCL7C_HUMAN	B-cell CLL/lymphoma 7 protein family member C	BCL7C	Homo sapiens (Human)	217	FUNCTION: May play an anti-apoptotic role. {ECO:0000250}.		apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; SWI/SNF complex [GO:0016514]		chromatin [GO:0000785]; GBAF complex [GO:0140288]; SWI/SNF complex [GO:0016514]; apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q8WV07	reviewed	LTO1_HUMAN	Protein LTO1 homolog (Oral cancer-overexpressed protein 1) (Tumor-amplified and overexpressed sequence 1)	LTO1 ORAOV1 TAOS1	Homo sapiens (Human)	137	FUNCTION: The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452). May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674). {ECO:0000269|PubMed:23318452, ECO:0000269|PubMed:24930674, ECO:0000269|PubMed:26182403}.	MISCELLANEOUS: Amplified and overexpressed in oral cancer cells.	protein maturation by [4Fe-4S] cluster transfer [GO:0106035]; ribosomal large subunit biogenesis [GO:0042273]; telomere maintenance [GO:0000723]; translational initiation [GO:0006413]	nucleus [GO:0005634]		nucleus [GO:0005634]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]; ribosomal large subunit biogenesis [GO:0042273]; telomere maintenance [GO:0000723]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53846}.
Q8WV48	reviewed	CC107_HUMAN	Coiled-coil domain-containing protein 107	CCDC107 PSEC0222	Homo sapiens (Human)	283				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8WV60	reviewed	PTCD2_HUMAN	Pentatricopeptide repeat-containing protein 2, mitochondrial	PTCD2	Homo sapiens (Human)	388	FUNCTION: Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function. {ECO:0000250}.		kidney development [GO:0001822]; liver development [GO:0001889]; mitochondrion organization [GO:0007005]; mRNA processing [GO:0006397]; muscle cell development [GO:0055001]; regulation of gene expression [GO:0010468]; regulation of mRNA processing [GO:0050684]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	mitochondrion [GO:0005739]	RNA binding [GO:0003723]	mitochondrion [GO:0005739]; RNA binding [GO:0003723]; kidney development [GO:0001822]; liver development [GO:0001889]; mitochondrion organization [GO:0007005]; mRNA processing [GO:0006397]; muscle cell development [GO:0055001]; regulation of gene expression [GO:0010468]; regulation of mRNA processing [GO:0050684]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18729827}.
Q8WVE0	reviewed	EFMT1_HUMAN	EEF1A lysine methyltransferase 1 (EC 2.1.1.-) (N(6)-adenine-specific DNA methyltransferase 2) (Protein-lysine N-methyltransferase N6AMT2) (eEF1A-KMT)	EEF1AKMT1 N6AMT2	Homo sapiens (Human)	214	FUNCTION: Protein N-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'. {ECO:0000255|HAMAP-Rule:MF_03187, ECO:0000269|PubMed:26545399, ECO:0000269|PubMed:28663172}.		peptidyl-lysine methylation [GO:0018022]	cytosol [GO:0005829]	histone methyltransferase activity [GO:0042054]; methyltransferase activity [GO:0008168]; nucleic acid binding [GO:0003676]; protein-lysine N-methyltransferase activity [GO:0016279]	cytosol [GO:0005829]; histone methyltransferase activity [GO:0042054]; methyltransferase activity [GO:0008168]; nucleic acid binding [GO:0003676]; protein-lysine N-methyltransferase activity [GO:0016279]; peptidyl-lysine methylation [GO:0018022]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03187}.
Q8WVH0	reviewed	CPLX3_HUMAN	Complexin-3 (Complexin III) (CPX III)	CPLX3 Nbla11589	Homo sapiens (Human)	158	FUNCTION: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). {ECO:0000250|UniProtKB:Q8R1B5}.		insulin secretion [GO:0030073]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; response to stimulus [GO:0050896]; synaptic vesicle exocytosis [GO:0016079]; visual perception [GO:0007601]	cytosol [GO:0005829]; photoreceptor ribbon synapse [GO:0098684]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	neurotransmitter transmembrane transporter activity [GO:0005326]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]	cytosol [GO:0005829]; photoreceptor ribbon synapse [GO:0098684]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; neurotransmitter transmembrane transporter activity [GO:0005326]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; insulin secretion [GO:0030073]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; response to stimulus [GO:0050896]; synaptic vesicle exocytosis [GO:0016079]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q8R1B5}. Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q8R1B5}. Note=Enriched at the synaptic terminal (By similarity). Localized at glycinergic synaptic contacts of AII amacrine cells with OFF cone bipolar cells in the OFF sublamina of the retina inner nuclear layer (By similarity). {ECO:0000250|UniProtKB:Q8R1B5}.
Q8WVI0	reviewed	UQCC5_HUMAN	Ubiquinol-cytochrome c reductase complex assembly factor 5 (Small integral membrane protein 4)	UQCC5 C3orf78 SMIM4	Homo sapiens (Human)	70	FUNCTION: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (By similarity). Mediates early complex III biogenesis (By similarity). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also involved in the first steps of cytochrome c oxidase complex (complex IV) assembly (PubMed:34969438). {ECO:0000250|UniProtKB:Q8C1Q6, ECO:0000269|PubMed:34969438}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex III assembly [GO:0034551]	mitochondrial inner membrane [GO:0005743]	mitochondrial ribosome binding [GO:0097177]	mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome binding [GO:0097177]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex III assembly [GO:0034551]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:34969438}; Single-pass membrane protein {ECO:0000255}.
Q8WVL7	reviewed	ANR49_HUMAN	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor)	ANKRD49 FGIF	Homo sapiens (Human)	239	FUNCTION: Induces HBG1 expression (PubMed:16131492, PubMed:11162141). May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway (By similarity). {ECO:0000250|UniProtKB:Q8VE42, ECO:0000269|PubMed:11162141, ECO:0000269|PubMed:16131492}.		cell differentiation [GO:0030154]; positive regulation of DNA-templated transcription [GO:0045893]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]		nucleus [GO:0005634]; cell differentiation [GO:0030154]; positive regulation of DNA-templated transcription [GO:0045893]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VE42}.
Q8WVZ7	reviewed	RN133_HUMAN	E3 ubiquitin-protein ligase RNF133 (EC 2.3.2.27) (RING finger protein 133) (RING-type E3 ubiquitin transferase RNF133)	RNF133	Homo sapiens (Human)	376	FUNCTION: Has E3 ubiquitin-protein ligase activity. {ECO:0000250|UniProtKB:Q14B02}.		protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14B02}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q14B02}.
Q8WW14	reviewed	SMIP5_HUMAN	Sperm-associated microtubule inner protein 5	SPMIP5 C10orf82	Homo sapiens (Human)	234	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella. {ECO:0000250|UniProtKB:A6QPC0}.			cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A6QPC0}. Cytoplasm {ECO:0000269|PubMed:25609838}. Nucleus {ECO:0000250|UniProtKB:Q9CQT6}. Note=Localizes to the A-tubules of DMTs (By similarity). Located in the cytoplasm of spermatocytes and the nuclei of round spermatids and elongated spermatids (By similarity). {ECO:0000250|UniProtKB:A6QPC0, ECO:0000250|UniProtKB:Q9CQT6}.
Q8WW27	reviewed	ABEC4_HUMAN	Putative C->U-editing enzyme APOBEC-4 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4)	APOBEC4 C1orf169	Homo sapiens (Human)	367	FUNCTION: Putative C to U editing enzyme whose physiological substrate is not yet known. {ECO:0000250}.		mRNA processing [GO:0006397]		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [GO:0016814]; zinc ion binding [GO:0008270]	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [GO:0016814]; zinc ion binding [GO:0008270]; mRNA processing [GO:0006397]	
Q8WWG1	reviewed	NRG4_HUMAN	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Cleaved into: Neuregulin-4 (NRG-4)]	NRG4	Homo sapiens (Human)	115	FUNCTION: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity). {ECO:0000250}.		ERBB4-ERBB4 signaling pathway [GO:0038138]; nervous system development [GO:0007399]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; ERBB4-ERBB4 signaling pathway [GO:0038138]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; SUBCELLULAR LOCATION: [Neuregulin-4]: Secreted {ECO:0000250}.
Q8WWW8	reviewed	GAB3_HUMAN	GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3)	GAB3	Homo sapiens (Human)	586			macrophage differentiation [GO:0030225]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]	signaling adaptor activity [GO:0035591]	cytoplasm [GO:0005737]; signaling adaptor activity [GO:0035591]; macrophage differentiation [GO:0030225]; signal transduction [GO:0007165]	
Q8WWY7	reviewed	WFD12_HUMAN	WAP four-disulfide core domain protein 12 (Putative protease inhibitor WAP12) (Whey acidic protein 2)	WFDC12 C20orf122 WAP2 UNQ544/PRO844	Homo sapiens (Human)	111	FUNCTION: Antibacterial protein. Putative acid-stable proteinase inhibitor.		antibacterial humoral response [GO:0019731]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; antibacterial humoral response [GO:0019731]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8WX77	reviewed	IBPL1_HUMAN	Insulin-like growth factor-binding protein-like 1 (IGFBP-related protein 10) (Insulin-like growth factor-binding-related protein 4) (IGFBP-rP4)	IGFBPL1 IGFBPRP4	Homo sapiens (Human)	278	FUNCTION: IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein. {ECO:0000250, ECO:0000269|PubMed:15845387}.		cellular response to tumor cell [GO:0071228]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]	insulin-like growth factor binding [GO:0005520]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; insulin-like growth factor binding [GO:0005520]; cellular response to tumor cell [GO:0071228]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15845387}.
Q8WXA2	reviewed	PATE1_HUMAN	Prostate and testis expressed protein 1	PATE1 PATE	Homo sapiens (Human)	126				extracellular region [GO:0005576]	acetylcholine receptor regulator activity [GO:0030548]	extracellular region [GO:0005576]; acetylcholine receptor regulator activity [GO:0030548]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8WXB4	reviewed	ZN606_HUMAN	Zinc finger protein 606 (Zinc finger protein 328)	ZNF606 KIAA1852 ZNF328	Homo sapiens (Human)	792	FUNCTION: May act as a transcriptional repressor. {ECO:0000269|PubMed:15964554}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15964554}.
Q8WXD9	reviewed	CSKI1_HUMAN	Caskin-1 (CASK-interacting protein 1)	CASKIN1 KIAA1306	Homo sapiens (Human)	1431	FUNCTION: May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.		signal transduction [GO:0007165]	cytoplasm [GO:0005737]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8WXH4	reviewed	ASB11_HUMAN	Ankyrin repeat and SOCS box protein 11 (ASB-11)	ASB11	Homo sapiens (Human)	323	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		intracellular signal transduction [GO:0035556]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]		cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular signal transduction [GO:0035556]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]	
Q8WXH6	reviewed	RB40A_HUMAN	Ras-related protein Rab-40A (SOCS box-containing protein RAR2A) (Protein Rar-2)	RAB40A	Homo sapiens (Human)	277	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		intracellular signal transduction [GO:0035556]; protein localization to plasma membrane [GO:0072659]; protein ubiquitination [GO:0016567]	endosome [GO:0005768]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endosome [GO:0005768]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular signal transduction [GO:0035556]; protein localization to plasma membrane [GO:0072659]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q8WXQ8	reviewed	CBPA5_HUMAN	Carboxypeptidase A5 (EC 3.4.17.-)	CPA5	Homo sapiens (Human)	436			proteolysis [GO:0006508]	extracellular space [GO:0005615]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	extracellular space [GO:0005615]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q8WY22	reviewed	BRI3B_HUMAN	BRI3-binding protein (I3-binding protein) (Cervical cancer 1 proto-oncogene-binding protein KG19) (HCCRBP-1)	BRI3BP KG19	Homo sapiens (Human)	251	FUNCTION: Involved in tumorigenesis and may function by stabilizing p53/TP53. {ECO:0000269|PubMed:17943721}.			mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000305|PubMed:17943721}; Multi-pass membrane protein {ECO:0000305|PubMed:17943721}.
Q8WYN3	reviewed	CSRN3_HUMAN	Cysteine/serine-rich nuclear protein 3 (CSRNP-3) (Protein FAM130A2) (TGF-beta-induced apoptosis protein 2) (TAIP-2)	CSRNP3 FAM130A2 TAIP2	Homo sapiens (Human)	585	FUNCTION: Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis (By similarity). {ECO:0000250}.		apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8WYQ4	reviewed	CV015_HUMAN	Uncharacterized protein C22orf15 (Protein N27C7-3)	C22orf15	Homo sapiens (Human)	148							
Q8WYQ9	reviewed	ZCH14_HUMAN	Zinc finger CCHC domain-containing protein 14 (BDG-29)	ZCCHC14 KIAA0579	Homo sapiens (Human)	949					nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270]	nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270]	
Q8WZ60	reviewed	KLHL6_HUMAN	Kelch-like protein 6	KLHL6	Homo sapiens (Human)	621	FUNCTION: Involved in B-lymphocyte antigen receptor signaling and germinal center formation. {ECO:0000250}.		B cell receptor signaling pathway [GO:0050853]; germinal center formation [GO:0002467]; response to bacterium [GO:0009617]			B cell receptor signaling pathway [GO:0050853]; germinal center formation [GO:0002467]; response to bacterium [GO:0009617]	
Q8WZ64	reviewed	ARAP2_HUMAN	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (Centaurin-delta-1) (Cnt-d1) (Protein PARX)	ARAP2 CENTD1 KIAA0580	Homo sapiens (Human)	1704	FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity). {ECO:0000250}.		signal transduction [GO:0007165]	cytoplasm [GO:0005737]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]	cytoplasm [GO:0005737]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8WZ79	reviewed	DNS2B_HUMAN	Deoxyribonuclease-2-beta (EC 3.1.22.1) (DNase II-like acid DNase) (DNase2-like acid DNase) (Deoxyribonuclease II beta) (DNase II beta) (Endonuclease DLAD)	DNASE2B DLAD	Homo sapiens (Human)	361	FUNCTION: Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. {ECO:0000269|PubMed:11700027, ECO:0000269|PubMed:12944971}.		apoptotic DNA fragmentation [GO:0006309]	extracellular region [GO:0005576]; lysosome [GO:0005764]	deoxyribonuclease II activity [GO:0004531]	extracellular region [GO:0005576]; lysosome [GO:0005764]; deoxyribonuclease II activity [GO:0004531]; apoptotic DNA fragmentation [GO:0006309]	SUBCELLULAR LOCATION: Lysosome {ECO:0000305}.
Q8WZ84	reviewed	OR8D1_HUMAN	Olfactory receptor 8D1 (OST004) (Olfactory receptor 8D3) (Olfactory receptor OR11-301) (Olfactory receptor-like protein JCG9)	OR8D1 OR8D3	Homo sapiens (Human)	308	FUNCTION: Odorant receptor (Potential). May be involved in taste perception. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8WZ94	reviewed	OR5P3_HUMAN	Olfactory receptor 5P3 (Olfactory receptor OR11-94) (Olfactory receptor-like protein JCG1)	OR5P3	Homo sapiens (Human)	311	FUNCTION: Odorant receptor (Potential). May be involved in taste perception. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q902F8	reviewed	ENK8_HUMAN	Endogenous retrovirus group K member 8 Env polyprotein (EnvK6 protein) (Envelope polyprotein) (HERV-K115 envelope protein) (HERV-K_8p23.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERVK-8	Homo sapiens (Human)	699	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: Insertional polymorphism. Provirus present in 16% of tested individuals.; MISCELLANEOUS: Has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.; MISCELLANEOUS: Intragenic, in first intron of DEFB107 gene.		plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.; SUBCELLULAR LOCATION: [Endogenous retrovirus group K member 8 Env polyprotein]: Virion {ECO:0000250}.
Q902F9	reviewed	EN113_HUMAN	Endogenous retrovirus group K member 113 Env polyprotein (EnvK5 protein) (Envelope polyprotein) (HERV-K113 envelope protein) (HERV-K_19p13.11 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	HERVK_113	Homo sapiens (Human)	699	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: Insertional polymorphism. Provirus present in 29% of tested individuals.; MISCELLANEOUS: Has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.		plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.; SUBCELLULAR LOCATION: [Endogenous retrovirus group K member 113 Env polyprotein]: Virion {ECO:0000250}.
Q92478	reviewed	CLC2B_HUMAN	C-type lectin domain family 2 member B (Activation-induced C-type lectin) (C-type lectin superfamily member 2) (IFN-alpha-2b-inducing-related protein 1)	CLEC2B AICL CLECSF2 IFNRG1	Homo sapiens (Human)	149				external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q92561	reviewed	PHYIP_HUMAN	Phytanoyl-CoA hydroxylase-interacting protein (Phytanoyl-CoA hydroxylase-associated protein 1) (PAHX-AP1) (PAHXAP1)	PHYHIP DYRK1AP3 KIAA0273	Homo sapiens (Human)	330	FUNCTION: Its interaction with PHYH suggests a role in the development of the central system.		protein localization [GO:0008104]	cytoplasm [GO:0005737]	protein tyrosine kinase binding [GO:1990782]	cytoplasm [GO:0005737]; protein tyrosine kinase binding [GO:1990782]; protein localization [GO:0008104]	
Q92610	reviewed	ZN592_HUMAN	Zinc finger protein 592	ZNF592 KIAA0211	Homo sapiens (Human)	1267	FUNCTION: May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.		negative regulation of insulin receptor signaling pathway [GO:0046627]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; PH domain binding [GO:0042731]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; PH domain binding [GO:0042731]; negative regulation of insulin receptor signaling pathway [GO:0046627]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q92617	reviewed	NPIB3_HUMAN	Nuclear pore complex-interacting protein family member B3 (Nuclear pore complex-interacting protein-like 3) (Protein pps22-1)	NPIPB3 KIAA0220 NPIPL3	Homo sapiens (Human)	1050				membrane [GO:0016020]; nuclear envelope [GO:0005635]		membrane [GO:0016020]; nuclear envelope [GO:0005635]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q92664	reviewed	TF3A_HUMAN	Transcription factor IIIA (TFIIIA)	GTF3A	Homo sapiens (Human)	365	FUNCTION: Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity). {ECO:0000250|UniProtKB:P17842, ECO:0000269|PubMed:24120868}.		ribosomal large subunit biogenesis [GO:0042273]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	5S rRNA binding [GO:0008097]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 5S rRNA binding [GO:0008097]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; ribosomal large subunit biogenesis [GO:0042273]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]	SUBCELLULAR LOCATION: Nucleus.
Q92686	reviewed	NEUG_HUMAN	Neurogranin (Ng) (RC3) [Cleaved into: NEUG(55-78)]	NRGN	Homo sapiens (Human)	78	FUNCTION: Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). {ECO:0000250}.		nervous system development [GO:0007399]; signal transduction [GO:0007165]	cytosol [GO:0005829]	calmodulin binding [GO:0005516]	cytosol [GO:0005829]; calmodulin binding [GO:0005516]; nervous system development [GO:0007399]; signal transduction [GO:0007165]	
Q92747	reviewed	ARC1A_HUMAN	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein)	ARPC1A SOP2L	Homo sapiens (Human)	370	FUNCTION: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. {ECO:0000305|PubMed:8978670}.		actin cytoskeleton organization [GO:0030036]; Arp2/3 complex-mediated actin nucleation [GO:0034314]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle cell projection membrane [GO:0036195]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	actin binding [GO:0003779]; actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle cell projection membrane [GO:0036195]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; actin cytoskeleton organization [GO:0030036]; Arp2/3 complex-mediated actin nucleation [GO:0034314]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8978670}. Nucleus {ECO:0000250|UniProtKB:Q8AVT9}.
Q92771	reviewed	DDX12_HUMAN	Putative ATP-dependent RNA helicase DDX12 (EC 3.6.4.13) (CHL1-related protein 2) (hCHLR2) (DEAD/H box protein 12)	DDX12P CHLR2 DDX12	Homo sapiens (Human)	950	FUNCTION: DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation (By similarity). {ECO:0000250}.		DNA duplex unwinding [GO:0032508]; establishment of sister chromatid cohesion [GO:0034085]; nucleobase-containing compound metabolic process [GO:0006139]	nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; DNA duplex unwinding [GO:0032508]; establishment of sister chromatid cohesion [GO:0034085]; nucleobase-containing compound metabolic process [GO:0006139]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q92806	reviewed	KCNJ9_HUMAN	G protein-activated inward rectifier potassium channel 3 (GIRK-3) (Inward rectifier K(+) channel Kir3.3) (Potassium channel, inwardly rectifying subfamily J member 9)	KCNJ9 GIRK3	Homo sapiens (Human)	393	FUNCTION: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity). {ECO:0000250}.		potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of presynaptic membrane potential [GO:0099505]	parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]	parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]; potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of presynaptic membrane potential [GO:0099505]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q92828	reviewed	COR2A_HUMAN	Coronin-2A (IR10) (WD repeat-containing protein 2)	CORO2A IR10 WDR2	Homo sapiens (Human)	525			intracellular signal transduction [GO:0035556]	transcription repressor complex [GO:0017053]	actin filament binding [GO:0051015]	transcription repressor complex [GO:0017053]; actin filament binding [GO:0051015]; intracellular signal transduction [GO:0035556]	
Q92914	reviewed	FGF11_HUMAN	Fibroblast growth factor 11 (FGF-11) (Fibroblast growth factor homologous factor 3) (FHF-3)	FGF11 FHF3	Homo sapiens (Human)	225	FUNCTION: Probably involved in nervous system development and function.		cell-cell signaling [GO:0007267]; nervous system development [GO:0007399]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	growth factor activity [GO:0008083]; sodium channel regulator activity [GO:0017080]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; growth factor activity [GO:0008083]; sodium channel regulator activity [GO:0017080]; cell-cell signaling [GO:0007267]; nervous system development [GO:0007399]; signal transduction [GO:0007165]	
Q92928	reviewed	RAB1C_HUMAN	Putative Ras-related protein Rab-1C (hRab1c) (EC 3.6.5.2)	RAB1C	Homo sapiens (Human)	201	FUNCTION: Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250|UniProtKB:P62820}.		autophagosome assembly [GO:0000045]; intracellular protein transport [GO:0006886]	cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; membrane [GO:0016020]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; membrane [GO:0016020]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagosome assembly [GO:0000045]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Membrane; Lipid-anchor; Cytoplasmic side {ECO:0000250|UniProtKB:P62820}. Cytoplasm {ECO:0000250|UniProtKB:P62820}.
Q93073	reviewed	SBP2L_HUMAN	Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like)	SECISBP2L KIAA0256	Homo sapiens (Human)	1101	FUNCTION: Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro.		selenocysteine incorporation [GO:0001514]	ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; selenocysteine insertion sequence binding [GO:0035368]	ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; selenocysteine insertion sequence binding [GO:0035368]; selenocysteine incorporation [GO:0001514]	
Q969I3	reviewed	GLYL1_HUMAN	Glycine N-acyltransferase-like protein 1 (EC 2.3.1.68) (Acyl-CoA:glycine N-acyltransferase-like protein 1) (Glutamine N-acyltransferase)	GLYATL1 GNAT	Homo sapiens (Human)	302	FUNCTION: Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor. {ECO:0000269|PubMed:22475485}.		glutamine metabolic process [GO:0006541]	mitochondrion [GO:0005739]	glutamine N-acyltransferase activity [GO:0047946]; glycine N-acyltransferase activity [GO:0047961]	mitochondrion [GO:0005739]; glutamine N-acyltransferase activity [GO:0047946]; glycine N-acyltransferase activity [GO:0047961]; glutamine metabolic process [GO:0006541]	
Q969M1	reviewed	TM40L_HUMAN	Mitochondrial import receptor subunit TOM40B (Protein TOMM40-like)	TOMM40L TOMM40B	Homo sapiens (Human)	308	FUNCTION: Potential channel-forming protein implicated in import of protein precursors into mitochondria. {ECO:0000250}.		monoatomic ion transport [GO:0006811]; protein import into mitochondrial matrix [GO:0030150]	mitochondrial outer membrane translocase complex [GO:0005742]; pore complex [GO:0046930]; protein-containing complex [GO:0032991]	mitochondrion targeting sequence binding [GO:0030943]; porin activity [GO:0015288]; preprotein binding [GO:0070678]; protein transmembrane transporter activity [GO:0008320]	mitochondrial outer membrane translocase complex [GO:0005742]; pore complex [GO:0046930]; protein-containing complex [GO:0032991]; mitochondrion targeting sequence binding [GO:0030943]; porin activity [GO:0015288]; preprotein binding [GO:0070678]; protein transmembrane transporter activity [GO:0008320]; monoatomic ion transport [GO:0006811]; protein import into mitochondrial matrix [GO:0030150]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q969M2	reviewed	CXA10_HUMAN	Gap junction alpha-10 protein (Connexin-62) (Cx62)	GJA10 CX62	Homo sapiens (Human)	543	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning (By similarity). {ECO:0000250}.		cell-cell signaling [GO:0007267]; detection of light stimulus involved in visual perception [GO:0050908]; gamete generation [GO:0007276]; synapse assembly [GO:0007416]	connexin complex [GO:0005922]; plasma membrane [GO:0005886]	gap junction channel activity [GO:0005243]	connexin complex [GO:0005922]; plasma membrane [GO:0005886]; gap junction channel activity [GO:0005243]; cell-cell signaling [GO:0007267]; detection of light stimulus involved in visual perception [GO:0050908]; gamete generation [GO:0007276]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
Q969N4	reviewed	TAAR8_HUMAN	Trace amine-associated receptor 8 (TaR-8) (Trace amine receptor 8) (G-protein coupled receptor 102) (Trace amine receptor 5) (TaR-5)	TAAR8 GPR102 TA5 TAR5 TRAR5	Homo sapiens (Human)	342	FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q969Q0	reviewed	RL36L_HUMAN	Ribosomal protein eL42-like (60S ribosomal protein L36a-like) (Large ribosomal subunit protein eL42-like)	RPL36AL	Homo sapiens (Human)	106		MISCELLANEOUS: This gene has no introns in its coding regions, and therefore, was most likely produced by retrotransposition of the original X-linked gene during evolution.	translation [GO:0006412]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q969Q4	reviewed	ARL11_HUMAN	ADP-ribosylation factor-like protein 11 (ADP-ribosylation factor-like tumor suppressor protein 1)	ARL11 ARLTS1	Homo sapiens (Human)	196	FUNCTION: May play a role in apoptosis. May act as a tumor suppressor. {ECO:0000269|PubMed:15843669}.		hematopoietic progenitor cell differentiation [GO:0002244]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	
Q969T3	reviewed	SNX21_HUMAN	Sorting nexin-21 (Sorting nexin L) (SNX-L)	SNX21 C20orf161 SNXL	Homo sapiens (Human)	373	FUNCTION: Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking. {ECO:0000250|UniProtKB:Q3UR97}.		protein transport [GO:0015031]	early endosome membrane [GO:0031901]	phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	early endosome membrane [GO:0031901]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q3UR97}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane {ECO:0000250|UniProtKB:Q3UR97}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3UR97}; Cytoplasmic side {ECO:0000250|UniProtKB:Q3UR97}.
Q969V1	reviewed	MCHR2_HUMAN	Melanin-concentrating hormone receptor 2 (MCH receptor 2) (MCH-R2) (MCHR-2) (G-protein coupled receptor 145) (GPRv17) (MCH-2R) (MCH2) (MCH2R)	MCHR2 GPR145 SLT	Homo sapiens (Human)	340	FUNCTION: Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.		neuropeptide signaling pathway [GO:0007218]	plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q969W8	reviewed	ZN566_HUMAN	Zinc finger protein 566	ZNF566	Homo sapiens (Human)	418	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96A00	reviewed	PP14A_HUMAN	Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiated inhibitory protein of PP1) (Protein kinase C-potentiated inhibitor protein of 17 kDa) (CPI-17)	PPP1R14A CPI17 PPP1INL	Homo sapiens (Human)	147	FUNCTION: Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.		regulation of phosphorylation [GO:0042325]	cytosol [GO:0005829]	protein serine/threonine phosphatase inhibitor activity [GO:0004865]	cytosol [GO:0005829]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; regulation of phosphorylation [GO:0042325]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96A04	reviewed	TSACC_HUMAN	TSSK6-activating co-chaperone protein (SSTK-interacting protein) (SIP) (SSTK-IP)	TSACC C1orf182	Homo sapiens (Human)	125	FUNCTION: Co-chaperone that facilitates HSP-mediated activation of TSSK6. {ECO:0000269|PubMed:20829357}.			cytoplasm [GO:0005737]	protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; protein-folding chaperone binding [GO:0051087]	
Q96A05	reviewed	VATE2_HUMAN	V-type proton ATPase subunit E 2 (V-ATPase subunit E 2) (Vacuolar proton pump subunit E 2)	ATP6V1E2 ATP6E1 ATP6EL2 ATP6V1EL2	Homo sapiens (Human)	226	FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. {ECO:0000250|UniProtKB:P36543}.		regulation of macroautophagy [GO:0016241]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; proton-transporting two-sector ATPase complex, catalytic domain [GO:0033178]	proton-transporting ATPase activity, rotational mechanism [GO:0046961]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; proton-transporting two-sector ATPase complex, catalytic domain [GO:0033178]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; regulation of macroautophagy [GO:0016241]	
Q96A23	reviewed	CPNE4_HUMAN	Copine-4 (Copine IV) (Copine-8)	CPNE4	Homo sapiens (Human)	557	FUNCTION: Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. {ECO:0000250|UniProtKB:Q99829}.		cellular response to calcium ion [GO:0071277]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]; cellular response to calcium ion [GO:0071277]	
Q96A28	reviewed	SLAF9_HUMAN	SLAM family member 9 (CD2 family member 10) (CD2F-10) (CD84 homolog 1) (CD84-H1)	SLAMF9 CD2F10 UNQ1938/PRO4421	Homo sapiens (Human)	289	FUNCTION: May play a role in the immune response. {ECO:0000269|PubMed:11300479}.		T cell activation [GO:0042110]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]		cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; T cell activation [GO:0042110]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q96A35	reviewed	RM24_HUMAN	Large ribosomal subunit protein uL24m (39S ribosomal protein L24, mitochondrial) (L24mt) (MRP-L24)	MRPL24	Homo sapiens (Human)	216			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q96A46	reviewed	MFRN2_HUMAN	Mitoferrin-2 (Mitochondrial RNA-splicing protein 3/4 homolog) (MRS3/4) (hMRS3/4) (Mitochondrial iron transporter 2) (Solute carrier family 25 member 28)	SLC25A28 MFRN2 NPD016	Homo sapiens (Human)	364	FUNCTION: Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. {ECO:0000250|UniProtKB:Q7T292}.		iron import into the mitochondrion [GO:0048250]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	ferrous iron transmembrane transporter activity [GO:0015093]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; ferrous iron transmembrane transporter activity [GO:0015093]; iron import into the mitochondrion [GO:0048250]	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane {ECO:0000305|PubMed:11297739}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion inner membrane {ECO:0000305|PubMed:11297739}; Multi-pass membrane protein {ECO:0000255}.
Q96A47	reviewed	ISL2_HUMAN	Insulin gene enhancer protein ISL-2 (Islet-2)	ISL2	Homo sapiens (Human)	359	FUNCTION: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. {ECO:0000250}.		axonogenesis [GO:0007409]; negative regulation of neuron differentiation [GO:0045665]; neuron development [GO:0048666]; neuron fate specification [GO:0048665]; peripheral nervous system neuron development [GO:0048935]; positive regulation of transcription by RNA polymerase II [GO:0045944]; retinal ganglion cell axon guidance [GO:0031290]; spinal cord motor neuron cell fate specification [GO:0021520]; visceral motor neuron differentiation [GO:0021524]	chromatin [GO:0000785]; nucleus [GO:0005634]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]; axonogenesis [GO:0007409]; negative regulation of neuron differentiation [GO:0045665]; neuron development [GO:0048666]; neuron fate specification [GO:0048665]; peripheral nervous system neuron development [GO:0048935]; positive regulation of transcription by RNA polymerase II [GO:0045944]; retinal ganglion cell axon guidance [GO:0031290]; spinal cord motor neuron cell fate specification [GO:0021520]; visceral motor neuron differentiation [GO:0021524]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q96A73	reviewed	P33MX_HUMAN	Putative monooxygenase p33MONOX (EC 1.-.-.-) (Brain-derived rescue factor p60MONOX) (Flavin monooxygenase motif-containing protein of 33 kDa)	KIAA1191 P33MONOX	Homo sapiens (Human)	305	FUNCTION: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.			cytoplasm [GO:0005737]	oxidoreductase activity [GO:0016491]	cytoplasm [GO:0005737]; oxidoreductase activity [GO:0016491]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96A84	reviewed	EMID1_HUMAN	EMI domain-containing protein 1 (Emilin and multimerin domain-containing protein 1) (Emu1)	EMID1 EMU1	Homo sapiens (Human)	441		MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be due to a competing acceptor splice site. {ECO:0000305}.		collagen trimer [GO:0005581]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]		collagen trimer [GO:0005581]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q96A99	reviewed	PTX4_HUMAN	Pentraxin-4	PTX4 C16orf38	Homo sapiens (Human)	478		MISCELLANEOUS: [Isoform 1]: Not expressed in small intestine. {ECO:0000305|PubMed:20357257}.		extracellular region [GO:0005576]	metal ion binding [GO:0046872]	extracellular region [GO:0005576]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96AC6	reviewed	KIFC2_HUMAN	Kinesin-like protein KIFC2	KIFC2	Homo sapiens (Human)	838	FUNCTION: May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity). {ECO:0000250}.		microtubule-based movement [GO:0007018]; mitotic spindle assembly [GO:0090307]	cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]; mitotic spindle assembly [GO:0090307]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
Q96AM1	reviewed	MRGRF_HUMAN	Mas-related G-protein coupled receptor member F (Mas-related gene F protein) (G-protein coupled receptor 140) (G-protein coupled receptor 168)	MRGPRF GPR140 GPR168 MRGF PSEC0142	Homo sapiens (Human)	343	FUNCTION: Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). {ECO:0000250}.		G protein-coupled receptor signaling pathway [GO:0007186]	nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96B77	reviewed	TM186_HUMAN	Transmembrane protein 186	TMEM186 C16orf51	Homo sapiens (Human)	213	FUNCTION: As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I. {ECO:0000269|PubMed:32320651}.		mitochondrial respiratory chain complex I assembly [GO:0032981]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; mitochondrial respiratory chain complex I assembly [GO:0032981]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:32320651, ECO:0000305|PubMed:32275929}; Multi-pass membrane protein {ECO:0000305}.
Q96BH3	reviewed	ESPB1_HUMAN	Epididymal sperm-binding protein 1 (Epididymal secretory protein 12) (hE12)	ELSPBP1 E12	Homo sapiens (Human)	223	FUNCTION: Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity). {ECO:0000250}.		single fertilization [GO:0007338]; sperm capacitation [GO:0048240]	cell surface [GO:0009986]; extracellular region [GO:0005576]	heparin binding [GO:0008201]	cell surface [GO:0009986]; extracellular region [GO:0005576]; heparin binding [GO:0008201]; single fertilization [GO:0007338]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11144225, ECO:0000269|PubMed:17307309}.
Q96BN6	reviewed	F149B_HUMAN	Primary cilium assembly protein FAM149B1	FAM149B1 KIAA0974	Homo sapiens (Human)	582	FUNCTION: Involved in the localization of proteins to the cilium and cilium assembly. Indirectly regulates the signaling functions of the cilium, being required for normal SHH/smoothened signaling and proper development. {ECO:0000269|PubMed:30905400}.		cilium assembly [GO:0060271]; protein localization to cilium [GO:0061512]	cilium [GO:0005929]		cilium [GO:0005929]; cilium assembly [GO:0060271]; protein localization to cilium [GO:0061512]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000305|PubMed:30905400}.
Q96BQ3	reviewed	TRI43_HUMAN	Tripartite motif-containing protein 43	TRIM43	Homo sapiens (Human)	446	FUNCTION: E3 ligase that regulates nuclear lamina integrity and the association of viral chromatin with transcriptionally-active host chromatin. Acts thereby as a herpesvirus-specific antiviral factor and mediates the ubiquitination-dependent proteasomal degradation of PCNT. {ECO:0000269|PubMed:30420784}.		innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30420784}.
Q96BU1	reviewed	S1PBP_HUMAN	S100P-binding protein (S100P-binding protein Riken)	S100PBP S100PBPR	Homo sapiens (Human)	408				cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	calcium-dependent protein binding [GO:0048306]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; calcium-dependent protein binding [GO:0048306]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15632002}. Note=Colocalizes with S100P in the nucleus. {ECO:0000269|PubMed:15632002}.
Q96BV0	reviewed	ZN775_HUMAN	Zinc finger protein 775	ZNF775	Homo sapiens (Human)	537	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96C19	reviewed	EFHD2_HUMAN	EF-hand domain-containing protein D2 (Swiprosin-1)	EFHD2 SWS1	Homo sapiens (Human)	240	FUNCTION: May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}.			membrane raft [GO:0045121]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	membrane raft [GO:0045121]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Membrane raft {ECO:0000250}. Note=In a mouse immature B-cell line WEHI-231. {ECO:0000250}.
Q96C28	reviewed	ZN707_HUMAN	Zinc finger protein 707	ZNF707	Homo sapiens (Human)	371	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96CM4	reviewed	NXNL1_HUMAN	Nucleoredoxin-like protein 1 (Thioredoxin-like protein 6)	NXNL1 TXNL6	Homo sapiens (Human)	212	FUNCTION: Plays an important role in retinal cone photoreceptor survival (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity). {ECO:0000250|UniProtKB:Q8VC33, ECO:0000269|PubMed:25957687}.		photoreceptor cell maintenance [GO:0045494]	photoreceptor outer segment [GO:0001750]		photoreceptor outer segment [GO:0001750]; photoreceptor cell maintenance [GO:0045494]	SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q8VC33}.
Q96CW6	reviewed	S7A6O_HUMAN	Probable RNA polymerase II nuclear localization protein SLC7A6OS (ADAMS proteinase-related protein) (Solute carrier family 7 member 6 opposite strand transcript)	SLC7A6OS	Homo sapiens (Human)	309	FUNCTION: Directs RNA polymerase II nuclear import. {ECO:0000250}.	MISCELLANEOUS: When transfected to S.cerevisiae cells, able to partially restore polymerase II mislocalization and cellular shape in IWR1 mutant cells. {ECO:0000305|PubMed:21504834}.	developmental process [GO:0032502]; hematopoietic progenitor cell differentiation [GO:0002244]; protein transport [GO:0015031]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; developmental process [GO:0032502]; hematopoietic progenitor cell differentiation [GO:0002244]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q96CX2	reviewed	KCD12_HUMAN	BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain)	KCTD12 C13orf2 KIAA1778 PFET1	Homo sapiens (Human)	325	FUNCTION: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}.		protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Presynaptic cell membrane. Postsynaptic cell membrane {ECO:0000250}.
Q96CX3	reviewed	ZN501_HUMAN	Zinc finger protein 501 (Zinc finger protein 52)	ZNF501 ZNF52	Homo sapiens (Human)	271	FUNCTION: May be involved in transcriptional regulation. Essential for Golgi structural integrity (PubMed:29851555). {ECO:0000269|PubMed:29851555}.	MISCELLANEOUS: [Isoform 2]: May be due to exon skipping. {ECO:0000305}.	Golgi organization [GO:0007030]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleolus [GO:0005730]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; Golgi organization [GO:0007030]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29851555}. Nucleus, nucleolus {ECO:0000269|PubMed:29851555}.
Q96DA0	reviewed	ZG16B_HUMAN	Zymogen granule protein 16 homolog B	ZG16B UNQ773/PRO1567	Homo sapiens (Human)	208			retina homeostasis [GO:0001895]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	carbohydrate binding [GO:0030246]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; carbohydrate binding [GO:0030246]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96DC8	reviewed	ECHD3_HUMAN	Enoyl-CoA hydratase domain-containing protein 3, mitochondrial	ECHDC3 PP1494 PP8332	Homo sapiens (Human)	303	FUNCTION: May play a role in fatty acid biosynthesis and insulin sensitivity. {ECO:0000269|PubMed:31010960}.		fatty acid metabolic process [GO:0006631]; positive regulation of cellular response to insulin stimulus [GO:1900078]	mitochondrion [GO:0005739]	enoyl-CoA hydratase activity [GO:0004300]; hydro-lyase activity [GO:0016836]	mitochondrion [GO:0005739]; enoyl-CoA hydratase activity [GO:0004300]; hydro-lyase activity [GO:0016836]; fatty acid metabolic process [GO:0006631]; positive regulation of cellular response to insulin stimulus [GO:1900078]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q96DD7	reviewed	SHSA4_HUMAN	Protein shisa-4 (Transmembrane protein 58)	SHISA4 C1orf40 TMEM58 UNQ583/PRO1153	Homo sapiens (Human)	197				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q96DN6	reviewed	MBD6_HUMAN	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6)	MBD6 KIAA1887	Homo sapiens (Human)	1003	FUNCTION: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).			chromocenter [GO:0010369]; chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	chromocenter [GO:0010369]; chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20700456}. Chromosome {ECO:0000269|PubMed:20700456}. Note=Associated with pericentric heterochromatin in about 25% of the cells.
Q96DT0	reviewed	LEG12_HUMAN	Galectin-12 (Gal-12) (Galectin-related inhibitor of proliferation)	LGALS12 GRIP1	Homo sapiens (Human)	336	FUNCTION: Binds lactose. May participate in the apoptosis of adipocytes.		intrinsic apoptotic signaling pathway [GO:0097193]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	lactose binding [GO:0030395]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; lactose binding [GO:0030395]; intrinsic apoptotic signaling pathway [GO:0097193]	SUBCELLULAR LOCATION: Nucleus.
Q96DX4	reviewed	RSPRY_HUMAN	RING finger and SPRY domain-containing protein 1	RSPRY1 KIAA1972 UNQ328/PRO444	Homo sapiens (Human)	576			proteolysis involved in protein catabolic process [GO:0051603]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; proteolysis involved in protein catabolic process [GO:0051603]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96DY7	reviewed	MTBP_HUMAN	Mdm2-binding protein (hMTBP)	MTBP	Homo sapiens (Human)	904	FUNCTION: Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}.		cell cycle [GO:0007049]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic nuclear division [GO:0045839]; protein localization to kinetochore [GO:0034501]; regulation of protein ubiquitination [GO:0031396]; traversing start control point of mitotic cell cycle [GO:0007089]	chromatin [GO:0000785]; kinetochore [GO:0000776]		chromatin [GO:0000785]; kinetochore [GO:0000776]; cell cycle [GO:0007049]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic nuclear division [GO:0045839]; protein localization to kinetochore [GO:0034501]; regulation of protein ubiquitination [GO:0031396]; traversing start control point of mitotic cell cycle [GO:0007089]	
Q96EF9	reviewed	ZHX1R_HUMAN	Zinc fingers and homeoboxes protein 1, isoform 2 (ZHX1-C8orf76 readthrough transcript protein)	ZHX1-C8orf76 C8orf76	Homo sapiens (Human)	292		MISCELLANEOUS: [Isoform 2]: Based on a readthrough transcript which may produce a ZHX1-C8orf76 fusion protein.					
Q96EH8	reviewed	NEUL3_HUMAN	E3 ubiquitin-protein ligase NEURL3 (EC 2.3.2.27) (Lung-inducible neuralized-related C3CH4 RING domain protein) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL3)	NEURL3 LINCR	Homo sapiens (Human)	262	FUNCTION: E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:30111563). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897). Inhibits also hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2 (PubMed:30111563). {ECO:0000269|PubMed:30111563, ECO:0000269|PubMed:35792897}.		innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; ubiquitin-dependent endocytosis [GO:0070086]	early endosome [GO:0005769]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	early endosome [GO:0005769]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; ubiquitin-dependent endocytosis [GO:0070086]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30111563, ECO:0000269|PubMed:35792897}.
Q96EK7	reviewed	F120B_HUMAN	Constitutive coactivator of peroxisome proliferator-activated receptor gamma (Constitutive coactivator of PPAR-gamma) (Constitutive coactivator of PPARG) (PPARG constitutive coactivator 1) (PGCC1) (Protein FAM120B)	FAM120B CCPG KIAA1838	Homo sapiens (Human)	910	FUNCTION: Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity). {ECO:0000250}.		fat cell differentiation [GO:0045444]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]	nucleus [GO:0005634]		nucleus [GO:0005634]; fat cell differentiation [GO:0045444]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96EN9	reviewed	REX1B_HUMAN	Required for excision 1-B domain-containing protein	REX1BD C19orf60	Homo sapiens (Human)	201							
Q96EY9	reviewed	ADAT3_HUMAN	Probable inactive tRNA-specific adenosine deaminase-like protein 3 (tRNA-specific adenosine-34 deaminase subunit ADAT3)	ADAT3 TAD3	Homo sapiens (Human)	351			tRNA processing [GO:0008033]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	catalytic activity [GO:0003824]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; catalytic activity [GO:0003824]; metal ion binding [GO:0046872]; tRNA processing [GO:0008033]	
Q96FC7	reviewed	PHIPL_HUMAN	Phytanoyl-CoA hydroxylase-interacting protein-like	PHYHIPL KIAA1796 UNQ6309/PRO20934	Homo sapiens (Human)	376	FUNCTION: May play a role in the development of the central system. {ECO:0000250}.			cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q96FH0	reviewed	BORC8_HUMAN	BLOC-1-related complex subunit 8 (MEF2B neighbor)	BORCS8 MEF2BNB	Homo sapiens (Human)	119	FUNCTION: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000305|PubMed:25898167}.		heart development [GO:0007507]; lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]	BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]		BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; heart development [GO:0007507]; lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000305|PubMed:25898167}.
Q96FN5	reviewed	KIF12_HUMAN	Kinesin-like protein KIF12	KIF12	Homo sapiens (Human)	646			microtubule-based movement [GO:0007018]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; kinesin complex [GO:0005871]; microtubule [GO:0005874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
Q96FN9	reviewed	DTD2_HUMAN	D-aminoacyl-tRNA deacylase 2 (EC 3.1.1.96) (Animalia-specific tRNA deacylase) (ATD) (D-tyrosyl-tRNA(Tyr) deacylase 2) (L-alanyl-tRNA deacylase)	DTD2 C14orf126	Homo sapiens (Human)	168	FUNCTION: Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity). {ECO:0000250|UniProtKB:Q8BHA3, ECO:0000269|PubMed:29410408}.		aminoacyl-tRNA metabolism involved in translational fidelity [GO:0106074]; tRNA metabolic process [GO:0006399]	cytoplasm [GO:0005737]	Ala-tRNA(Thr) hydrolase activity [GO:0106105]; D-tyrosyl-tRNA(Tyr) deacylase activity [GO:0051500]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; Ala-tRNA(Thr) hydrolase activity [GO:0106105]; D-tyrosyl-tRNA(Tyr) deacylase activity [GO:0051500]; tRNA binding [GO:0000049]; aminoacyl-tRNA metabolism involved in translational fidelity [GO:0106074]; tRNA metabolic process [GO:0006399]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q96FV2	reviewed	SCRN2_HUMAN	Secernin-2	SCRN2	Homo sapiens (Human)	425			proteolysis [GO:0006508]	extracellular exosome [GO:0070062]	cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805]	extracellular exosome [GO:0070062]; cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805]; proteolysis [GO:0006508]	
Q96FV3	reviewed	TSN17_HUMAN	Tetraspanin-17 (Tspan-17) (F-box only protein 23) (Tetraspan protein SB134) (Transmembrane 4 superfamily member 17)	TSPAN17 FBXO23 TM4SF17	Homo sapiens (Human)	270	FUNCTION: Regulates ADAM10 maturation. {ECO:0000250|UniProtKB:Q9D7W4}.		establishment of protein localization to organelle [GO:0072594]; protein ubiquitination [GO:0016567]	membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151]	enzyme binding [GO:0019899]; ubiquitin-protein transferase activity [GO:0004842]	membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151]; enzyme binding [GO:0019899]; ubiquitin-protein transferase activity [GO:0004842]; establishment of protein localization to organelle [GO:0072594]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96GA3	reviewed	LTV1_HUMAN	Protein LTV1 homolog	LTV1 C6orf93	Homo sapiens (Human)	475			ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34999892}. Note=The protein is expressed in a diffuse cytoplasmic pattern with granular perinuclear accentuation within the basal keratinocytes. {ECO:0000269|PubMed:34999892}.
Q96GC5	reviewed	RM48_HUMAN	Large ribosomal subunit protein mL48 (39S ribosomal protein L48, mitochondrial) (L48mt) (MRP-L48)	MRPL48 CGI-118 HSPC290	Homo sapiens (Human)	212			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q96GE9	reviewed	DMAC1_HUMAN	Distal membrane-arm assembly complex protein 1 (Transmembrane protein 261)	DMAC1 C9orf123 TMEM261	Homo sapiens (Human)	116	FUNCTION: Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. {ECO:0000269|PubMed:27626371}.		mitochondrial respiratory chain complex I assembly [GO:0032981]	mitochondrial inner membrane [GO:0005743]		mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I assembly [GO:0032981]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:27626371}; Multi-pass membrane protein {ECO:0000305}.
Q96GX2	reviewed	A7L3B_HUMAN	Ataxin-7-like protein 3B	ATXN7L3B	Homo sapiens (Human)	97	FUNCTION: By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3. {ECO:0000269|PubMed:27601583}.	MISCELLANEOUS: Encoded by an expressed retrotransposed copy of the ATXN7L3 locus that emerged prior to the speciation event separating primates and rodents.	regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27601583}.
Q96GX8	reviewed	CP074_HUMAN	Uncharacterized protein C16orf74	C16orf74	Homo sapiens (Human)	76		MISCELLANEOUS: May act as a prognostic marker of median survival time in pancreatic cancer patients. {ECO:0000269|PubMed:28881575}.					
Q96GY0	reviewed	ZC21A_HUMAN	Zinc finger C2HC domain-containing protein 1A	ZC2HC1A C8orf70 FAM164A CGI-62	Homo sapiens (Human)	325					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q96H78	reviewed	S2544_HUMAN	Solute carrier family 25 member 44	SLC25A44 KIAA0446	Homo sapiens (Human)	314	FUNCTION: Mitochondrial solute transporter which transports branched-chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue (BAT) (By similarity). BAT is involved in BCAA catabolism and actively utilizes BCAA in the mitochondria for thermogenesis (PubMed:31435015). {ECO:0000250|UniProtKB:Q8BGF9, ECO:0000269|PubMed:31435015}.		branched-chain amino acid catabolic process [GO:0009083]; branched-chain amino acid transport [GO:0015803]; regulation of cold-induced thermogenesis [GO:0120161]	mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	branched-chain amino acid transmembrane transporter activity [GO:0015658]	mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; branched-chain amino acid transmembrane transporter activity [GO:0015658]; branched-chain amino acid catabolic process [GO:0009083]; branched-chain amino acid transport [GO:0015803]; regulation of cold-induced thermogenesis [GO:0120161]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q8BGF9}; Multi-pass membrane protein {ECO:0000255}.
Q96HE9	reviewed	PRR11_HUMAN	Proline-rich protein 11	PRR11	Homo sapiens (Human)	360	FUNCTION: Plays a critical role in cell cycle progression. {ECO:0000269|PubMed:23246489}.		regulation of cell cycle [GO:0051726]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23242552, ECO:0000269|PubMed:23246489}. Nucleus {ECO:0000269|PubMed:23246489}.
Q96HJ9	reviewed	FMC1_HUMAN	Protein FMC1 homolog (ATP synthase assembly factor FMC1, mitochondrial) (Formation of mitochondrial complex V assembly factor 1 homolog)	FMC1 C7orf55 HSPC268	Homo sapiens (Human)	113	FUNCTION: Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) (PubMed:28719601). {ECO:0000269|PubMed:28719601}.		mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; negative regulation of lipid catabolic process [GO:0050995]; regulation of type B pancreatic cell proliferation [GO:0061469]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; negative regulation of lipid catabolic process [GO:0050995]; regulation of type B pancreatic cell proliferation [GO:0061469]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:28719601}.
Q96HL8	reviewed	SH3Y1_HUMAN	SH3 domain-containing YSC84-like protein 1	SH3YL1	Homo sapiens (Human)	342			phosphatidylinositol biosynthetic process [GO:0006661]; regulation of ruffle assembly [GO:1900027]	ruffle membrane [GO:0032587]	phosphatase binding [GO:0019902]; phosphatidylinositol binding [GO:0035091]	ruffle membrane [GO:0032587]; phosphatase binding [GO:0019902]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol biosynthetic process [GO:0006661]; regulation of ruffle assembly [GO:1900027]	
Q96HQ0	reviewed	ZN419_HUMAN	Zinc finger protein 419	ZNF419 ZNF419A	Homo sapiens (Human)	510	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96HQ2	reviewed	C2AIL_HUMAN	CDKN2AIP N-terminal-like protein (CDKN2A-interacting protein N-terminal-like protein)	CDKN2AIPNL	Homo sapiens (Human)	116							
Q96HU8	reviewed	DIRA2_HUMAN	GTP-binding protein Di-Ras2 (Distinct subgroup of the Ras family member 2)	DIRAS2	Homo sapiens (Human)	199	FUNCTION: Displays low GTPase activity and exists predominantly in the GTP-bound form. {ECO:0000269|PubMed:12194967}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q96I36	reviewed	COX14_HUMAN	Cytochrome c oxidase assembly protein COX14	COX14 C12orf62	Homo sapiens (Human)	57	FUNCTION: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. {ECO:0000269|PubMed:22243966, ECO:0000269|PubMed:22356826}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; mitochondrial cytochrome c oxidase assembly [GO:0033617]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:22243966, ECO:0000269|PubMed:22356826, ECO:0000269|PubMed:27184847}; Single-pass membrane protein {ECO:0000255}.
Q96I82	reviewed	KAZD1_HUMAN	Kazal-type serine protease inhibitor domain-containing protein 1	KAZALD1 FKSG28 FKSG40 UNQ2945/PRO21184	Homo sapiens (Human)	304	FUNCTION: Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; ossification [GO:0001503]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966]	extracellular space [GO:0005615]; interstitial matrix [GO:0005614]	insulin-like growth factor binding [GO:0005520]	extracellular space [GO:0005615]; interstitial matrix [GO:0005614]; insulin-like growth factor binding [GO:0005520]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; ossification [GO:0001503]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q96IG2	reviewed	FXL20_HUMAN	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like)	FBXL20 FBL2	Homo sapiens (Human)	436	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}.		behavioral fear response [GO:0001662]; regulation of protein catabolic process at presynapse, modulating synaptic transmission [GO:0099575]; regulation of synaptic vesicle exocytosis [GO:2000300]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793]; SCF ubiquitin ligase complex [GO:0019005]; Schaffer collateral - CA1 synapse [GO:0098685]		cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793]; SCF ubiquitin ligase complex [GO:0019005]; Schaffer collateral - CA1 synapse [GO:0098685]; behavioral fear response [GO:0001662]; regulation of protein catabolic process at presynapse, modulating synaptic transmission [GO:0099575]; regulation of synaptic vesicle exocytosis [GO:2000300]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96IK0	reviewed	TM101_HUMAN	Transmembrane protein 101 (Putative NF-kappa-B-activating protein 130)	TMEM101	Homo sapiens (Human)	257	FUNCTION: May activate NF-kappa-B signaling pathways. {ECO:0000269|PubMed:12761501}.		positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	membrane [GO:0016020]		membrane [GO:0016020]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96IQ7	reviewed	VSIG2_HUMAN	V-set and immunoglobulin domain-containing protein 2 (Cortical thymocyte-like protein) (CT-like protein)	VSIG2 CTH CTXL UNQ2770/PRO7154	Homo sapiens (Human)	327			lipid metabolic process [GO:0006629]	membrane [GO:0016020]; plasma membrane [GO:0005886]		membrane [GO:0016020]; plasma membrane [GO:0005886]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q96IX9	reviewed	A26L1_HUMAN	Putative ankyrin repeat domain-containing protein 26-like 1 (Ankyrin repeat domain-containing protein 36B pseudogene 1)	ANKRD36BP1 ANKRD26L1	Homo sapiens (Human)	119							
Q96J86	reviewed	CYYR1_HUMAN	Cysteine and tyrosine-rich protein 1 (Proline-rich domain-containing protein)	CYYR1 C21orf95	Homo sapiens (Human)	154				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q96J88	reviewed	ESIP1_HUMAN	Epithelial-stromal interaction protein 1	EPSTI1	Homo sapiens (Human)	318	FUNCTION: Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity). Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity). {ECO:0000250|UniProtKB:Q8VDI1}.						
Q96JA4	reviewed	M4A14_HUMAN	Membrane-spanning 4-domains subfamily A member 14 (Testis development protein NYD-SP21)	MS4A14 MS4A13 MS4A16	Homo sapiens (Human)	679	FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex. {ECO:0000250}.		cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96JC4	reviewed	ZN479_HUMAN	Zinc finger protein 479 (Zinc finger protein Kr19) (HKr19)	ZNF479	Homo sapiens (Human)	524	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96JK4	reviewed	HIPL1_HUMAN	HHIP-like protein 1	HHIPL1 HHIP2 KIAA1822 UNQ9245/PRO34761	Homo sapiens (Human)	782				extracellular region [GO:0005576]; membrane [GO:0016020]		extracellular region [GO:0005576]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96JN8	reviewed	NEUL4_HUMAN	Neuralized-like protein 4	NEURL4 KIAA1787	Homo sapiens (Human)	1562	FUNCTION: Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}.			centriole [GO:0005814]; cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]	centriole [GO:0005814]; cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}. Note=Localizes to procentriole and daughter centriole in growing and quiescent cells (PubMed:22441691). May loose association with centrosomes during mitosis (PubMed:22261722). {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}.
Q96JP2	reviewed	MY15B_HUMAN	Unconventional myosin-XVB (Myosin XVBP) (Unconventional myosin-15B)	MYO15B KIAA1783 MYO15BP	Homo sapiens (Human)	1530	FUNCTION: Unknown, due to the absence of a functional motor domain.			cytoplasm [GO:0005737]; myosin complex [GO:0016459]	ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]	cytoplasm [GO:0005737]; myosin complex [GO:0016459]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q96JQ2	reviewed	CLMN_HUMAN	Calmin (Calponin-like transmembrane domain protein)	CLMN KIAA1188	Homo sapiens (Human)	1002			negative regulation of cell population proliferation [GO:0008285]; neuron projection development [GO:0031175]; nuclear migration [GO:0007097]	cytoplasm [GO:0005737]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear outer membrane [GO:0005640]	actin filament binding [GO:0051015]	cytoplasm [GO:0005737]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear outer membrane [GO:0005640]; actin filament binding [GO:0051015]; negative regulation of cell population proliferation [GO:0008285]; neuron projection development [GO:0031175]; nuclear migration [GO:0007097]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Q96JT2	reviewed	S45A3_HUMAN	Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein)	SLC45A3 PCANAP6 PRST	Homo sapiens (Human)	553	FUNCTION: Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q8K0H7}.	MISCELLANEOUS: Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas-directed cytotoxic T-cell lymphocytes.	hexose transmembrane transport [GO:0008645]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glucose metabolic process [GO:0010907]; regulation of oligodendrocyte differentiation [GO:0048713]; sucrose transport [GO:0015770]	membrane [GO:0016020]; plasma membrane [GO:0005886]	sucrose:proton symporter activity [GO:0008506]; sugar transmembrane transporter activity [GO:0051119]	membrane [GO:0016020]; plasma membrane [GO:0005886]; sucrose:proton symporter activity [GO:0008506]; sugar transmembrane transporter activity [GO:0051119]; hexose transmembrane transport [GO:0008645]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glucose metabolic process [GO:0010907]; regulation of oligodendrocyte differentiation [GO:0048713]; sucrose transport [GO:0015770]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96K49	reviewed	TM87B_HUMAN	Transmembrane protein 87B	TMEM87B	Homo sapiens (Human)	555	FUNCTION: May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}.		retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]		cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:26157166}; Multi-pass membrane protein {ECO:0000255}.
Q96K62	reviewed	ZBT45_HUMAN	Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499)	ZBTB45 ZNF499	Homo sapiens (Human)	511	FUNCTION: May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity). {ECO:0000250|UniProtKB:Q52KG4, ECO:0000305}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	nucleoplasm [GO:0005654]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleoplasm [GO:0005654]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96KC2	reviewed	ARL5B_HUMAN	ADP-ribosylation factor-like protein 5B (ADP-ribosylation factor-like protein 8)	ARL5B ARL8	Homo sapiens (Human)	179	FUNCTION: Binds and exchanges GTP and GDP.		intracellular protein transport [GO:0006886]; protein localization to Golgi membrane [GO:1903292]; vesicle-mediated transport [GO:0016192]	trans-Golgi network [GO:0005802]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	trans-Golgi network [GO:0005802]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; protein localization to Golgi membrane [GO:1903292]; vesicle-mediated transport [GO:0016192]	
Q96KE9	reviewed	BTBD6_HUMAN	BTB/POZ domain-containing protein 6 (Lens BTB domain protein)	BTBD6 BDPL	Homo sapiens (Human)	538	FUNCTION: Adapter protein for the cul3 E3 ubiquitin-protein ligase complex (By similarity). Involved in late neuronal development and muscle formation (By similarity). {ECO:0000250|UniProtKB:A9JRD8, ECO:0000250|UniProtKB:Q2LE78}.		neurogenesis [GO:0022008]	cytosol [GO:0005829]		cytosol [GO:0005829]; neurogenesis [GO:0022008]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q2LE78}. Note=Found in punctated bodies in the cytoplasm. {ECO:0000250|UniProtKB:Q2LE78}.
Q96KJ9	reviewed	COX42_HUMAN	Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (Cytochrome c oxidase subunit IV isoform 2) (COX IV-2)	COX4I2 COX4L2	Homo sapiens (Human)	171	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}.		cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	mitochondrial respiratory chain complex IV [GO:0005751]	cytochrome-c oxidase activity [GO:0004129]	mitochondrial respiratory chain complex IV [GO:0005751]; cytochrome-c oxidase activity [GO:0004129]; cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00423}; Single-pass membrane protein {ECO:0000250|UniProtKB:P00423}.
Q96KN1	reviewed	LRAT2_HUMAN	Protein LRATD2 (Breast cancer membrane protein 101) (LRAT domain-containing 2) (Protein FAM84B) (Protein NSE2)	LRATD2 BCMP101 FAM84B NSE2	Homo sapiens (Human)	310				cytoplasm [GO:0005737]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	
Q96KR1	reviewed	ZFR_HUMAN	Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog)	ZFR	Homo sapiens (Human)	1074	FUNCTION: Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}.			chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules (By similarity). {ECO:0000250}.
Q96KS9	reviewed	F167A_HUMAN	Protein FAM167A	FAM167A C8orf13	Homo sapiens (Human)	214							
Q96KX0	reviewed	LYZL4_HUMAN	Lysozyme-like protein 4 (Lysozyme-4)	LYZL4 LYC4	Homo sapiens (Human)	146	FUNCTION: May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity). {ECO:0000250|UniProtKB:D4ABW7, ECO:0000250|UniProtKB:Q9D925}.		fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	lysozyme activity [GO:0003796]	acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; lysozyme activity [GO:0003796]; fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9D925}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9D925}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D925}. Note=Found in the principal piece of sperm tail. {ECO:0000250|UniProtKB:Q9D925}.
Q96KX2	reviewed	CAZA3_HUMAN	F-actin-capping protein subunit alpha-3 (CapZ alpha-3) (CP-alpha-3) (Germ cell-specific protein 3)	CAPZA3 CAPAA3 GSG3	Homo sapiens (Human)	299	FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity). {ECO:0000250}.		actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]	cortical cytoskeleton [GO:0030863]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; membrane [GO:0016020]; nucleus [GO:0005634]	actin filament binding [GO:0051015]	cortical cytoskeleton [GO:0030863]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; membrane [GO:0016020]; nucleus [GO:0005634]; actin filament binding [GO:0051015]; actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]	
Q96L14	reviewed	C170L_HUMAN	Cep170-like protein (CEP170 pseudogene 1)	CEP170P1 CEP170L KIAA0470L	Homo sapiens (Human)	293					identical protein binding [GO:0042802]	identical protein binding [GO:0042802]	
Q96L15	reviewed	NAR5_HUMAN	Ecto-ADP-ribosyltransferase 5 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 5) (ARTC5) (Mono(ADP-ribosyl)transferase 5) (NAD(P)(+)--arginine ADP-ribosyltransferase 5)	ART5 UNQ575/PRO1137	Homo sapiens (Human)	291				extracellular region [GO:0005576]	NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779]	extracellular region [GO:0005576]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96L33	reviewed	RHOV_HUMAN	Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)	RHOV ARHV WRCH2	Homo sapiens (Human)	236	FUNCTION: Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway. {ECO:0000250|UniProtKB:Q9Z1Y0}.		actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]	endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]	endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Z1Y0}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z1Y0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z1Y0}. Endosome membrane {ECO:0000250|UniProtKB:Q9Z1Y0}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z1Y0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z1Y0}. Note=Treatment with TNF activates endosomal but not plasma membrane RHOV. {ECO:0000250|UniProtKB:Q9Z1Y0}.
Q96L94	reviewed	SNX22_HUMAN	Sorting nexin-22	SNX22	Homo sapiens (Human)	193	FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:17400918). {ECO:0000250|UniProtKB:Q9D2Y5, ECO:0000269|PubMed:17400918}.		protein transport [GO:0015031]	cytoplasmic vesicle membrane [GO:0030659]	phosphatidylinositol phosphate binding [GO:1901981]	cytoplasmic vesicle membrane [GO:0030659]; phosphatidylinositol phosphate binding [GO:1901981]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q3UR97}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3UR97}; Cytoplasmic side {ECO:0000250|UniProtKB:Q3UR97}.
Q96LA9	reviewed	MRGX4_HUMAN	Mas-related G-protein coupled receptor member X4 (Sensory neuron-specific G-protein coupled receptor 5/6)	MRGPRX4 MRGX4 SNSR5 SNSR6	Homo sapiens (Human)	322	FUNCTION: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity). {ECO:0000250}.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96LB4	reviewed	VATG3_HUMAN	V-type proton ATPase subunit G 3 (V-ATPase subunit G 3) (V-ATPase 13 kDa subunit 3) (Vacuolar proton pump subunit G 3)	ATP6V1G3 ATP6G3	Homo sapiens (Human)	118	FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. {ECO:0000250|UniProtKB:O75348}.			cytosol [GO:0005829]; plasma membrane [GO:0005886]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]	ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	
Q96LD1	reviewed	SGCZ_HUMAN	Zeta-sarcoglycan (Zeta-SG) (ZSG1)	SGCZ	Homo sapiens (Human)	299	FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity). {ECO:0000250}.		cardiac muscle tissue development [GO:0048738]; heart contraction [GO:0060047]; membrane organization [GO:0061024]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]; cardiac muscle tissue development [GO:0048738]; heart contraction [GO:0060047]; membrane organization [GO:0061024]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]	SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Q96LL3	reviewed	FIMP_HUMAN	Fertilization-influencing membrane protein	FIMP C16orf92	Homo sapiens (Human)	132	FUNCTION: May play a role in sperm-oocyte fusion during fertilization. {ECO:0000250|UniProtKB:E9Q9R3}.		fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E9Q9R3}; Single-pass type I membrane protein {ECO:0000305}.
Q96LR9	reviewed	APLD1_HUMAN	Apolipoprotein L domain-containing protein 1 (Vascular early response gene protein)	APOLD1 VERGE	Homo sapiens (Human)	279	FUNCTION: May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability. {ECO:0000269|PubMed:15102925}.		angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; regulation of endothelial cell differentiation [GO:0045601]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	lipid binding [GO:0008289]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; lipid binding [GO:0008289]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; regulation of endothelial cell differentiation [GO:0045601]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:15102925}; Multi-pass membrane protein {ECO:0000305|PubMed:15102925}.
Q96LW2	reviewed	KS6R_HUMAN	Ribosomal protein S6 kinase-related protein (EC 2.7.11.1) (Sugen kinase 494)	RSKR SGK494	Homo sapiens (Human)	410		MISCELLANEOUS: [Isoform 3]: May be due to an intron retention. {ECO:0000305}.	phosphorylation [GO:0016310]		ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	
Q96LW9	reviewed	ZSC31_HUMAN	Zinc finger and SCAN domain-containing protein 31 (Zinc finger protein 323)	ZSCAN31 ZNF310P ZNF323	Homo sapiens (Human)	406	FUNCTION: May function as a transcription factor. May be involved in the development of multiple embryonic organs.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96LY2	reviewed	CC74B_HUMAN	Coiled-coil domain-containing protein 74B	CCDC74B	Homo sapiens (Human)	380							
Q96M27	reviewed	PRRC1_HUMAN	Protein PRRC1 (Proline-rich and coiled-coil-containing protein 1)	PRRC1	Homo sapiens (Human)	445		MISCELLANEOUS: [Isoform 2]: Non-canonical splice sites for exon 9 and exon 10. {ECO:0000305}.		cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]	protein kinase A regulatory subunit binding [GO:0034237]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; protein kinase A regulatory subunit binding [GO:0034237]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:15541471}.
Q96M69	reviewed	LRGUK_HUMAN	Leucine-rich repeat and guanylate kinase domain-containing protein	LRGUK	Homo sapiens (Human)	825	FUNCTION: Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. {ECO:0000250|UniProtKB:Q9D5S7}.		axoneme assembly [GO:0035082]; cell differentiation [GO:0030154]; phosphorylation [GO:0016310]; spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]; cell projection [GO:0042995]; cytosol [GO:0005829]; manchette [GO:0002177]	ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385]	acrosomal vesicle [GO:0001669]; cell projection [GO:0042995]; cytosol [GO:0005829]; manchette [GO:0002177]; ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385]; axoneme assembly [GO:0035082]; cell differentiation [GO:0030154]; phosphorylation [GO:0016310]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9D5S7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9D5S7}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9D5S7}. Note=Localizes to the acrosome and acroplaxome in round spermatids. Localizes to the manchette during spermiogenesis. Also found in the basal body of elongating spermatids, and in primary cilia of somatic cells. {ECO:0000250|UniProtKB:Q9D5S7}.
Q96M83	reviewed	CCDC7_HUMAN	Coiled-coil domain-containing protein 7 (Protein BIOT2)	CCDC7 BIOT2 C10orf68	Homo sapiens (Human)	1385	FUNCTION: May play a role in tumorigenesis. {ECO:0000250|UniProtKB:Q9D541}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q96M89	reviewed	CC138_HUMAN	Coiled-coil domain-containing protein 138	CCDC138	Homo sapiens (Human)	665							
Q96MA1	reviewed	DMRTB_HUMAN	Doublesex- and mab-3-related transcription factor B1	DMRTB1	Homo sapiens (Human)	342			germ cell development [GO:0007281]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; germ cell development [GO:0007281]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Q96MB7	reviewed	HARB1_HUMAN	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	HARBI1 C11orf77	Homo sapiens (Human)	349	FUNCTION: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. {ECO:0000269|PubMed:15169610, ECO:0000269|PubMed:18339812, ECO:0000305}.			centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; nuclease activity [GO:0004518]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18339812}. Cytoplasm {ECO:0000269|PubMed:18339812}. Note=Interaction with NAIF1 promotes translocation to the nucleus.
Q96ME1	reviewed	FXL18_HUMAN	F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18)	FBXL18 FBL18	Homo sapiens (Human)	718	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.		SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]		cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	
Q96MH6	reviewed	TMM68_HUMAN	Monoacylglycerol/Diacylglycerol O-acyltransferase (MGAT/DGAT) (EC 2.3.1.20) (EC 2.3.1.22) (2-acylglycerol/1,2-diacylglycerol O-acyltransferase) (Transmembrane protein 68) (Tmem68)	TMEM68	Homo sapiens (Human)	324	FUNCTION: Acyltransferase that regulates cellular triglyceride (TG) content and glycerolipid composition via the monoglyceride pathway. Primarily acyl-CoA:monoacylglycerol acyltransferase (MGAT), but can also exhibit acyl-CoA:diacylglycerol acyltransferase (DGAT) activity. By regulating the synthesis of diglyceride precursors, it may affect the levels of glycerophospholipids such as phosphatidylcholine, phosphatidylinositol and phosphatidylethanolamine. Plays a role in lipogenesis by inducing the expression of some key regulators such as diglyceride acyltransferases (DGATs) and enzymes of de novo fatty acid synthesis. {ECO:0000250|UniProtKB:Q9D850}.		lipid metabolic process [GO:0006629]	endoplasmic reticulum membrane [GO:0005789]	acyltransferase activity [GO:0016746]	endoplasmic reticulum membrane [GO:0005789]; acyltransferase activity [GO:0016746]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D850}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9D850}.
Q96MI6	reviewed	PPM1M_HUMAN	Protein phosphatase 1M (EC 3.1.3.16) (Protein phosphatase 2C isoform eta) (PP2C-eta) (PP2CE)	PPM1M PPM1E	Homo sapiens (Human)	459			protein dephosphorylation [GO:0006470]	mitochondrion [GO:0005739]; nucleus [GO:0005634]	[pyruvate dehydrogenase (lipoamide)] phosphatase activity [GO:0004741]; manganese ion binding [GO:0030145]; myosin phosphatase activity [GO:0017018]	mitochondrion [GO:0005739]; nucleus [GO:0005634]; [pyruvate dehydrogenase (lipoamide)] phosphatase activity [GO:0004741]; manganese ion binding [GO:0030145]; myosin phosphatase activity [GO:0017018]; protein dephosphorylation [GO:0006470]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96MM6	reviewed	HS12B_HUMAN	Heat shock 70 kDa protein 12B	HSPA12B C20orf60	Homo sapiens (Human)	686					ATP binding [GO:0005524]	ATP binding [GO:0005524]	
Q96MT1	reviewed	RN145_HUMAN	RING finger protein 145 (EC 2.3.2.27)	RNF145	Homo sapiens (Human)	663	FUNCTION: E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately down-regulating cholesterol biosynthesis. {ECO:0000250|UniProtKB:Q5SWK7}.			endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	transferase activity [GO:0016740]; zinc ion binding [GO:0008270]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5SWK7}; Multi-pass membrane protein {ECO:0000255}.
Q96MX6	reviewed	DAA10_HUMAN	Dynein axonemal assembly factor 10 (WD repeat-containing protein 92) (WD repeat-containing protein Monad)	DNAAF10 WDR92	Homo sapiens (Human)	357	FUNCTION: Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm. {ECO:0000250|UniProtKB:A8J3F6}.		apoptotic process [GO:0006915]; axonemal dynein complex assembly [GO:0070286]; protein stabilization [GO:0050821]	dynein axonemal particle [GO:0120293]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]	ubiquitin binding [GO:0043130]	dynein axonemal particle [GO:0120293]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; ubiquitin binding [GO:0043130]; apoptotic process [GO:0006915]; axonemal dynein complex assembly [GO:0070286]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Dynein axonemal particle {ECO:0000250|UniProtKB:A8J3F6}.
Q96N06	reviewed	SPT33_HUMAN	Spermatogenesis-associated protein 33	SPATA33 C16orf55	Homo sapiens (Human)	139	FUNCTION: Plays an important role in sperm motility and male fertility (By similarity). Required for sperm midpiece flexibility and for the localization of sperm calcineurin to the mitochondria (By similarity). Promotes mitophagy as well as acts as an autophagy mediator in male germline cells (By similarity). Links damaged mitochondria to autophagosomes via its binding to the outer mitochondrial membrane protein VDAC2, as well as to key autophagy machinery component ATG16L1 (By similarity). {ECO:0000250|UniProtKB:Q8C624}.		mitophagy [GO:0000423]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; sperm midpiece [GO:0097225]; sperm mitochondrial sheath [GO:0097226]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; sperm midpiece [GO:0097225]; sperm mitochondrial sheath [GO:0097226]; mitophagy [GO:0000423]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8C624}. Nucleus {ECO:0000250|UniProtKB:Q8C624}. Cytoplasm {ECO:0000250|UniProtKB:Q8C624}. Mitochondrion {ECO:0000250|UniProtKB:Q8C624}.
Q96N23	reviewed	CFA54_HUMAN	Cilia- and flagella-associated protein 54	CFAP54 C12orf55 C12orf63	Homo sapiens (Human)	3096	FUNCTION: Required for assembly and function of cilia and flagella. {ECO:0000250|UniProtKB:Q8C6S9}.	MISCELLANEOUS: [Isoform 1]: Gene prediction based on partial mRNA data.; MISCELLANEOUS: [Isoform 2]: Incomplete sequence. {ECO:0000305}.	cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283]	axoneme [GO:0005930]; extracellular region [GO:0005576]		axoneme [GO:0005930]; extracellular region [GO:0005576]; cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A8J666}.
Q96N28	reviewed	PLD3A_HUMAN	PRELI domain containing protein 3A (Protein slowmo homolog 1)	PRELID3A C18orf43 SLMO1	Homo sapiens (Human)	172	FUNCTION: In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane. {ECO:0000305|PubMed:26071602}.		phospholipid transport [GO:0015914]	mitochondrial intermembrane space [GO:0005758]	phosphatidic acid transfer activity [GO:1990050]	mitochondrial intermembrane space [GO:0005758]; phosphatidic acid transfer activity [GO:1990050]; phospholipid transport [GO:0015914]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q96N38	reviewed	ZN714_HUMAN	Zinc finger protein 714	ZNF714	Homo sapiens (Human)	554	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96ND0	reviewed	F210A_HUMAN	Protein FAM210A	FAM210A C18orf19	Homo sapiens (Human)	272	FUNCTION: May play a role in the structure and strength of both muscle and bone. {ECO:0000250|UniProtKB:Q8BGY7}.			cytoplasm [GO:0005737]; membrane [GO:0016020]; mitochondrion [GO:0005739]		cytoplasm [GO:0005737]; membrane [GO:0016020]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Membrane {ECO:0000255, ECO:0000305}; Single-pass membrane protein {ECO:0000255}. Mitochondrion {ECO:0000250|UniProtKB:Q8BGY7}. Cytoplasm {ECO:0000250|UniProtKB:Q8BGY7}.
Q96NL0	reviewed	RUN3B_HUMAN	RUN domain-containing protein 3B (Rap2-binding protein 9) (Rap2-interacting protein 9) (RPIP-9)	RUNDC3B RPIB9 RPIP9	Homo sapiens (Human)	473							
Q96NL1	reviewed	TMM74_HUMAN	Transmembrane protein 74	TMEM74	Homo sapiens (Human)	305	FUNCTION: Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction. {ECO:0000269|PubMed:18294959, ECO:0000269|PubMed:19029833}.		general adaptation syndrome, behavioral process [GO:0051867]; macroautophagy [GO:0016236]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	transmembrane transporter binding [GO:0044325]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; transmembrane transporter binding [GO:0044325]; general adaptation syndrome, behavioral process [GO:0051867]; macroautophagy [GO:0016236]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:18294959}; Multi-pass membrane protein {ECO:0000269|PubMed:18294959}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:18294959}; Multi-pass membrane protein {ECO:0000269|PubMed:18294959}.
Q96NL3	reviewed	ZN599_HUMAN	Zinc finger protein 599	ZNF599	Homo sapiens (Human)	588	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96NU0	reviewed	CNT3B_HUMAN	Contactin-associated protein-like 3B (Cell recognition molecule Caspr3b)	CNTNAP3B CASPR3B	Homo sapiens (Human)	1288		MISCELLANEOUS: The gene encoding CNTNAP3B is the result of a pericentromeric duplication of the genomic region encoding CNTNAP3 on chromosome 9.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell adhesion [GO:0007155]	membrane [GO:0016020]		membrane [GO:0016020]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q96NX9	reviewed	DACH2_HUMAN	Dachshund homolog 2 (Dach2)	DACH2	Homo sapiens (Human)	599	FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain. {ECO:0000250}.		development of primary female sexual characteristics [GO:0046545]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; development of primary female sexual characteristics [GO:0046545]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96P15	reviewed	SPB11_HUMAN	Serpin B11	SERPINB11	Homo sapiens (Human)	392	FUNCTION: Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change. {ECO:0000269|PubMed:17562709}.			cytoplasm [GO:0005737]; extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96P50	reviewed	ACAP3_HUMAN	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 (Centaurin-beta-5) (Cnt-b5)	ACAP3 CENTB5 KIAA1716	Homo sapiens (Human)	834	FUNCTION: GTPase-activating protein for the ADP ribosylation factor family. {ECO:0000305}.		neuron migration [GO:0001764]; regulation of neuron projection development [GO:0010975]	cytoplasm [GO:0005737]; growth cone [GO:0030426]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; growth cone [GO:0030426]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; neuron migration [GO:0001764]; regulation of neuron projection development [GO:0010975]	
Q96P68	reviewed	OXGR1_HUMAN	2-oxoglutarate receptor 1 (Alpha-ketoglutarate receptor 1) (G-protein coupled receptor 80) (G-protein coupled receptor 99) (P2Y purinoceptor 15) (P2Y15) (P2Y-like GPCR) (P2Y-like nucleotide receptor)	OXGR1 GPR80 GPR99 P2RY15 P2Y15	Homo sapiens (Human)	337	FUNCTION: Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity). {ECO:0000250}.		G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96P69	reviewed	GPR78_HUMAN	G-protein coupled receptor 78	GPR78 UNQ5925/PRO19818	Homo sapiens (Human)	363	FUNCTION: Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. {ECO:0000269|PubMed:17363172}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96P88	reviewed	GNRR2_HUMAN	Putative gonadotropin-releasing hormone II receptor (GnRH II receptor) (GnRH-II-R) (Type II GnRH receptor)	GNRHR2	Homo sapiens (Human)	292	FUNCTION: Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional. {ECO:0000269|PubMed:12538601, ECO:0000269|PubMed:19657181}.		cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	gonadotropin-releasing hormone receptor activity [GO:0004968]; peptide binding [GO:0042277]	plasma membrane [GO:0005886]; gonadotropin-releasing hormone receptor activity [GO:0004968]; peptide binding [GO:0042277]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96PB8	reviewed	LRC3B_HUMAN	Leucine-rich repeat-containing protein 3B (Leucine-rich repeat protein 15)	LRRC3B LRP15 UNQ195/PRO221	Homo sapiens (Human)	259				extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96PE2	reviewed	ARHGH_HUMAN	Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4)	ARHGEF17 KIAA0337 TEM4	Homo sapiens (Human)	2063	FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.		actin cytoskeleton organization [GO:0030036]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytosol [GO:0005829]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; guanyl-nucleotide exchange factor activity [GO:0005085]; actin cytoskeleton organization [GO:0030036]; regulation of small GTPase mediated signal transduction [GO:0051056]	
Q96PE5	reviewed	OPALI_HUMAN	Opalin (Oligodendrocytic myelin paranodal and inner loop protein) (Transmembrane protein 10)	OPALIN HTMP10 TMEM10	Homo sapiens (Human)	141	FUNCTION: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation. {ECO:0000250|UniProtKB:Q7M750}.		regulation of oligodendrocyte differentiation [GO:0048713]	cell-cell contact zone [GO:0044291]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]		cell-cell contact zone [GO:0044291]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; regulation of oligodendrocyte differentiation [GO:0048713]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7M750}; Single-pass type I membrane protein {ECO:0000255}. Note=In the CNS, enriched in the myelin paranodal and inner loop membranes, but not that of the PNS. Enriched in the leading edge of extending processes. {ECO:0000250|UniProtKB:Q7M750}.
Q96PE6	reviewed	ZIM3_HUMAN	Zinc finger imprinted 3 (Zinc finger protein 657)	ZIM3 ZNF657	Homo sapiens (Human)	472	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96PL1	reviewed	SG3A2_HUMAN	Secretoglobin family 3A member 2 (Pneumo secretory protein 1) (PnSP-1) (Uteroglobin-related protein 1)	SCGB3A2 PNSP1 UGRP1 UNQ566/PRO1128	Homo sapiens (Human)	93	FUNCTION: Secreted cytokine-like protein (PubMed:12847263). Binds to the scavenger receptor MARCO (PubMed:12847263). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung (PubMed:24213919). May play a role in fetal lung development and maturation (PubMed:24213919). Promotes branching morphogenesis during early stages of lung development (PubMed:24213919). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (By similarity). {ECO:0000250|UniProtKB:Q920H1, ECO:0000269|PubMed:12847263, ECO:0000269|PubMed:24213919}.			endocytic vesicle lumen [GO:0071682]; extracellular region [GO:0005576]; extracellular space [GO:0005615]		endocytic vesicle lumen [GO:0071682]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12847263}.
Q96PL2	reviewed	TECTB_HUMAN	Beta-tectorin	TECTB	Homo sapiens (Human)	329	FUNCTION: One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. {ECO:0000250}.			cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	extracellular matrix structural constituent [GO:0005201]	cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; extracellular matrix structural constituent [GO:0005201]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}; Extracellular side {ECO:0000305}. Secreted, extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane. {ECO:0000250}.
Q96PQ7	reviewed	KLHL5_HUMAN	Kelch-like protein 5	KLHL5	Homo sapiens (Human)	755		MISCELLANEOUS: [Isoform 2]: May be due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: Ubiquitous expression, differentially expressed in kidney and pancreas relatively to isoform 1. {ECO:0000305}.		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]	actin binding [GO:0003779]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; actin binding [GO:0003779]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
Q96PU9	reviewed	CMA1A_HUMAN	Ciliary microtubule associated protein 1A (Outer dense fiber of sperm tails protein 3) (Outer dense fiber protein 3) (Sperm tail protein SHIPPO 1) (Transcript induced in spermiogenesis protein 50)	CIMAP1A ODF3 SHIPPO1 TISP50	Homo sapiens (Human)	254	FUNCTION: Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail. {ECO:0000250|UniProtKB:Q920N1}.	MISCELLANEOUS: 'Shippo' is a Japanese word for tail. {ECO:0000250|UniProtKB:Q920N1}.	cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; outer dense fiber [GO:0001520]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; outer dense fiber [GO:0001520]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q920N1}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q920N1}. Note=Expressed in the cytoplasmic lobe of spermatids. {ECO:0000250|UniProtKB:Q920N1}.
Q96PX9	reviewed	PKH4B_HUMAN	Pleckstrin homology domain-containing family G member 4B (PH domain-containing family G member 4B)	PLEKHG4B KIAA1909	Homo sapiens (Human)	1271			axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056]	
Q96QR1	reviewed	SG3A1_HUMAN	Secretoglobin family 3A member 1 (Cytokine HIN-1) (High in normal 1) (Pneumo secretory protein 2) (PnSP-2) (Uteroglobin-related protein 2)	SCGB3A1 HIN1 PNSP2 UGRP2 UNQ629/PRO1245	Homo sapiens (Human)	104	FUNCTION: Secreted cytokine-like protein. Inhibits cell growth in vitro. {ECO:0000269|PubMed:11481438}.		negative regulation of cell growth [GO:0030308]; positive regulation of myoblast fusion [GO:1901741]; regulation of cell population proliferation [GO:0042127]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; negative regulation of cell growth [GO:0030308]; positive regulation of myoblast fusion [GO:1901741]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11481438}.
Q96QS1	reviewed	TSN32_HUMAN	Tetraspanin-32 (Tspan-32) (Protein Phemx)	TSPAN32 PHEMX TSSC6	Homo sapiens (Human)	320		MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell-cell signaling [GO:0007267]; cytoskeleton organization [GO:0007010]; defense response to protozoan [GO:0042832]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of myeloid dendritic cell activation [GO:0030886]; negative regulation of T cell proliferation [GO:0042130]; platelet aggregation [GO:0070527]; regulation of defense response to virus [GO:0050688]; T cell proliferation [GO:0042098]	cell surface [GO:0009986]; integrin alphaIIb-beta3 complex [GO:0070442]		cell surface [GO:0009986]; integrin alphaIIb-beta3 complex [GO:0070442]; cell-cell signaling [GO:0007267]; cytoskeleton organization [GO:0007010]; defense response to protozoan [GO:0042832]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of myeloid dendritic cell activation [GO:0030886]; negative regulation of T cell proliferation [GO:0042130]; platelet aggregation [GO:0070527]; regulation of defense response to virus [GO:0050688]; T cell proliferation [GO:0042098]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96QU6	reviewed	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase-like protein 1 (ACC synthase-like protein 1)	ACCS PHACS	Homo sapiens (Human)	501	FUNCTION: Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine. {ECO:0000269|PubMed:11470512}.		amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058]		identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]	identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058]	
Q96R48	reviewed	OR2A5_HUMAN	Olfactory receptor 2A5 (Olfactory receptor 2A26) (Olfactory receptor 2A8) (Olfactory receptor 7-138/7-141) (OR7-138) (OR7-141)	OR2A5 OR2A26 OR2A8	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RA2	reviewed	OR7D2_HUMAN	Olfactory receptor 7D2 (HTPCRH03) (Olfactory receptor 19-4) (OR19-4) (Olfactory receptor OR19-10)	OR7D2	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RD6	reviewed	PANX2_HUMAN	Pannexin-2	PANX2	Homo sapiens (Human)	677	FUNCTION: Structural component of the gap junctions and the hemichannels. {ECO:0000250}.		cell-cell signaling [GO:0007267]; monoatomic cation transport [GO:0006812]; positive regulation of interleukin-1 production [GO:0032732]; response to ischemia [GO:0002931]	cytoplasm [GO:0005737]; gap junction [GO:0005921]; plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]; wide pore channel activity [GO:0022829]	cytoplasm [GO:0005737]; gap junction [GO:0005921]; plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]; wide pore channel activity [GO:0022829]; cell-cell signaling [GO:0007267]; monoatomic cation transport [GO:0006812]; positive regulation of interleukin-1 production [GO:0032732]; response to ischemia [GO:0002931]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap junction.
Q96RI9	reviewed	TAAR9_HUMAN	Trace amine-associated receptor 9 (TaR-9) (Trace amine receptor 9) (Trace amine receptor 3) (TaR-3)	TAAR9 TA3 TAR3 TRAR3	Homo sapiens (Human)	348	FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RJ0	reviewed	TAAR1_HUMAN	Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1)	TAAR1 TA1 TAR1 TRAR1	Homo sapiens (Human)	339	FUNCTION: Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. {ECO:0000269|PubMed:15718104}.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RK1	reviewed	CITE4_HUMAN	Cbp/p300-interacting transactivator 4 (MSG1-related protein 2) (MRG-2)	CITED4 MRG2	Homo sapiens (Human)	184	FUNCTION: Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}.		response to estrogen [GO:0043627]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; response to estrogen [GO:0043627]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}. Cytoplasm {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}.
Q96RV3	reviewed	PCX1_HUMAN	Pecanex-like protein 1 (Pecanex homolog protein 1)	PCNX1 KIAA0805 KIAA0995 PCNX PCNXL1	Homo sapiens (Human)	2341				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q96S79	reviewed	RSLAB_HUMAN	Ras-like protein family member 10B (EC 3.6.5.2) (Ras-like protein VTS58635) (Ras-related protein 17) (RRP17)	RASL10B	Homo sapiens (Human)	203	FUNCTION: May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure. {ECO:0000250}.		positive regulation of peptide hormone secretion [GO:0090277]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050]	plasma membrane [GO:0005886]	G protein activity [GO:0003925]; GTP binding [GO:0005525]	plasma membrane [GO:0005886]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; positive regulation of peptide hormone secretion [GO:0090277]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q96S90	reviewed	LYSM1_HUMAN	LysM and putative peptidoglycan-binding domain-containing protein 1	LYSMD1 SB145	Homo sapiens (Human)	227				nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	
Q96S96	reviewed	PEBP4_HUMAN	Phosphatidylethanolamine-binding protein 4 (PEBP-4) (hPEBP4) (Protein cousin-of-RKIP 1)	PEBP4 CORK1 UNQ1933/PRO4408	Homo sapiens (Human)	227	FUNCTION: Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway. {ECO:0000269|PubMed:27033522}.			extracellular exosome [GO:0070062]		extracellular exosome [GO:0070062]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27033522}.
Q96SE0	reviewed	ABHD1_HUMAN	Protein ABHD1 (EC 3.1.1.-) (Alpha/beta hydrolase domain-containing protein 1) (Abhydrolase domain-containing protein 1) (Lung alpha/beta hydrolase 1)	ABHD1 LABH1	Homo sapiens (Human)	405			medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793]	membrane [GO:0016020]	acetylesterase activity [GO:0008126]; acylglycerol lipase activity [GO:0047372]	membrane [GO:0016020]; acetylesterase activity [GO:0008126]; acylglycerol lipase activity [GO:0047372]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q96SE7	reviewed	ZN347_HUMAN	Zinc finger protein 347 (Zinc finger protein 1111)	ZNF347 ZNF1111	Homo sapiens (Human)	839	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96SJ8	reviewed	TSN18_HUMAN	Tetraspanin-18 (Tspan-18)	TSPAN18 UNQ3042/PRO9858	Homo sapiens (Human)	248	FUNCTION: Plays a role in the cell surface localization of ORAI1 and may participate in the regulation of Ca(2+) signaling and the VWF release in response to inflammatory stimuli. {ECO:0000269|PubMed:30573509}.		calcium-ion regulated exocytosis [GO:0017156]; establishment of localization in cell [GO:0051649]; hemostasis [GO:0007599]; inflammatory response [GO:0006954]; regulation of sprouting angiogenesis [GO:1903670]	membrane [GO:0016020]		membrane [GO:0016020]; calcium-ion regulated exocytosis [GO:0017156]; establishment of localization in cell [GO:0051649]; hemostasis [GO:0007599]; inflammatory response [GO:0006954]; regulation of sprouting angiogenesis [GO:1903670]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q96SK3	reviewed	ZN607_HUMAN	Zinc finger protein 607	ZNF607	Homo sapiens (Human)	696	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96SL8	reviewed	FIZ1_HUMAN	Flt3-interacting zinc finger protein 1 (Zinc finger protein 798)	FIZ1 ZNF798	Homo sapiens (Human)	496	FUNCTION: May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). {ECO:0000250}.		positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q96SM3	reviewed	CPXM1_HUMAN	Probable carboxypeptidase X1 (EC 3.4.17.-) (Metallocarboxypeptidase CPX-1)	CPXM1 CPX1 CPXM UNQ3015/PRO9782	Homo sapiens (Human)	734	FUNCTION: May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity). {ECO:0000250}.		peptide metabolic process [GO:0006518]; protein processing [GO:0016485]	extracellular space [GO:0005615]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	extracellular space [GO:0005615]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]; peptide metabolic process [GO:0006518]; protein processing [GO:0016485]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q96SN7	reviewed	ORAI2_HUMAN	Protein orai-2 (CAP-binding protein complex-interacting protein 2) (Transmembrane protein 142B)	ORAI2 C7orf19 CBCIP2 TMEM142B PP1729	Homo sapiens (Human)	254	FUNCTION: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1. {ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:17452328}.		store-operated calcium entry [GO:0002115]	growth cone [GO:0030426]; membrane [GO:0016020]	store-operated calcium channel activity [GO:0015279]	growth cone [GO:0030426]; membrane [GO:0016020]; store-operated calcium channel activity [GO:0015279]; store-operated calcium entry [GO:0002115]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q96SR6	reviewed	ZN382_HUMAN	Zinc finger protein 382 (KRAB/zinc finger suppressor protein 1) (KS1) (Multiple zinc finger and krueppel-associated box protein KS1)	ZNF382	Homo sapiens (Human)	550	FUNCTION: Functions as a sequence-specific transcriptional repressor. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96SY0	reviewed	INT14_HUMAN	Integrator complex subunit 14 (von Willebrand factor A domain-containing protein 9)	INTS14 C15orf44 VWA9	Homo sapiens (Human)	518	FUNCTION: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. {ECO:0000250|UniProtKB:Q9VPY0}.		regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VPY0}.
Q96T25	reviewed	ZIC5_HUMAN	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5)	ZIC5	Homo sapiens (Human)	663	FUNCTION: Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96T92	reviewed	INSM2_HUMAN	Insulinoma-associated protein 2 (Zinc finger protein IA-6)	INSM2 IA6 Nbla106	Homo sapiens (Human)	566	FUNCTION: May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; regulation of cell cycle process [GO:0010564]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; regulation of cell cycle process [GO:0010564]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q99218	reviewed	AMELY_HUMAN	Amelogenin, Y isoform	AMELY AMGL AMGY	Homo sapiens (Human)	206	FUNCTION: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.		enamel mineralization [GO:0070166]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]	structural constituent of tooth enamel [GO:0030345]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; structural constituent of tooth enamel [GO:0030345]; enamel mineralization [GO:0070166]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
Q99442	reviewed	SEC62_HUMAN	Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1)	SEC62 TLOC1	Homo sapiens (Human)	399	FUNCTION: Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. {ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}.		cotranslational protein targeting to membrane [GO:0006613]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791]	signaling receptor activity [GO:0038023]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791]; signaling receptor activity [GO:0038023]; cotranslational protein targeting to membrane [GO:0006613]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q99445	reviewed	GML_HUMAN	Glycosyl-phosphatidylinositol-anchored molecule-like protein	GML LY6DL	Homo sapiens (Human)	158	FUNCTION: May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage.		apoptotic process [GO:0006915]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; negative regulation of cell population proliferation [GO:0008285]	extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; apoptotic process [GO:0006915]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; negative regulation of cell population proliferation [GO:0008285]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Q99525	reviewed	H4G_HUMAN	Histone H4-like protein type G (H4-clustered histone 7)	H4C7 H4/L H4FL HIST1H4G	Homo sapiens (Human)	98	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). {ECO:0000250}.		nucleosome assembly [GO:0006334]	nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Q99614	reviewed	TTC1_HUMAN	Tetratricopeptide repeat protein 1 (TPR repeat protein 1)	TTC1 TPR1	Homo sapiens (Human)	292			protein folding [GO:0006457]	cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]	unfolded protein binding [GO:0051082]	cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]	
Q99618	reviewed	CDCA3_HUMAN	Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1)	CDCA3 C8 GRCC8 TOME1	Homo sapiens (Human)	268	FUNCTION: F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}.		cell cycle [GO:0007049]; cell division [GO:0051301]; protein ubiquitination [GO:0016567]	adherens junction [GO:0005912]; cytosol [GO:0005829]		adherens junction [GO:0005912]; cytosol [GO:0005829]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
Q99666	reviewed	RGPD5_HUMAN	RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63)	RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6	Homo sapiens (Human)	1765		MISCELLANEOUS: One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.	NLS-bearing protein import into nucleus [GO:0006607]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]		cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; NLS-bearing protein import into nucleus [GO:0006607]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15710750}.
Q99678	reviewed	GPR20_HUMAN	G-protein coupled receptor 20	GPR20	Homo sapiens (Human)	358	FUNCTION: Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP. {ECO:0000269|PubMed:18347022}.		phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled receptor activity [GO:0004930]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled receptor activity [GO:0004930]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18347022}; Multi-pass membrane protein {ECO:0000269|PubMed:18347022}.
Q99727	reviewed	TIMP4_HUMAN	Metalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) (TIMP-4)	TIMP4	Homo sapiens (Human)	224	FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.		negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; Notch signaling pathway [GO:0007219]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]	metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; Notch signaling pathway [GO:0007219]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]	SUBCELLULAR LOCATION: Secreted.
Q99742	reviewed	NPAS1_HUMAN	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5)	NPAS1 BHLHE11 MOP5 PASD5	Homo sapiens (Human)	590	FUNCTION: May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity). Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97459}.		central nervous system development [GO:0007417]; maternal behavior [GO:0042711]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; startle response [GO:0001964]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; central nervous system development [GO:0007417]; maternal behavior [GO:0042711]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; startle response [GO:0001964]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q99805	reviewed	TM9S2_HUMAN	Transmembrane 9 superfamily member 2 (p76)	TM9SF2	Homo sapiens (Human)	663	FUNCTION: In the intracellular compartments, may function as a channel or small molecule transporter. {ECO:0000305|PubMed:9729438}.		ceramide metabolic process [GO:0006672]; glycosphingolipid biosynthetic process [GO:0006688]; protein localization to membrane [GO:0072657]; regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010908]	cytoskeleton [GO:0005856]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]		cytoskeleton [GO:0005856]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ceramide metabolic process [GO:0006672]; glycosphingolipid biosynthetic process [GO:0006688]; protein localization to membrane [GO:0072657]; regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010908]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000305|PubMed:9729438}; Multi-pass membrane protein {ECO:0000255}. Golgi outpost {ECO:0000250|UniProtKB:Q66HG5}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q66HG5}. Note=Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. {ECO:0000250|UniProtKB:Q66HG5}.
Q99811	reviewed	PRRX2_HUMAN	Paired mesoderm homeobox protein 2 (Paired-related homeobox protein 2) (PRX-2)	PRRX2 PMX2 PRX2	Homo sapiens (Human)	253	FUNCTION: May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development. {ECO:0000269|PubMed:9665387}.		regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Q99819	reviewed	GDIR3_HUMAN	Rho GDP-dissociation inhibitor 3 (Rho GDI 3) (Rho-GDI gamma)	ARHGDIG	Homo sapiens (Human)	225	FUNCTION: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.		blastocyst hatching [GO:0001835]; negative regulation of cell adhesion [GO:0007162]; regulation of protein localization [GO:0032880]; Rho protein signal transduction [GO:0007266]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; Rho GDP-dissociation inhibitor activity [GO:0005094]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; Rho GDP-dissociation inhibitor activity [GO:0005094]; blastocyst hatching [GO:0001835]; negative regulation of cell adhesion [GO:0007162]; regulation of protein localization [GO:0032880]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Cytoplasm.
Q99865	reviewed	SPI2A_HUMAN	Spindlin-2A (Protein DXF34) (Spindlin-like protein 2A) (SPIN-2) (SPIN-2A)	SPIN2A DXF34 SPIN2	Homo sapiens (Human)	258	FUNCTION: May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity (PubMed:29061846). {ECO:0000250|UniProtKB:Q9BPZ2, ECO:0000269|PubMed:29061846}.		cell cycle [GO:0007049]; gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	methylated histone binding [GO:0035064]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; methylated histone binding [GO:0035064]; cell cycle [GO:0007049]; gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BPZ2}.
Q99954	reviewed	SMR3A_HUMAN	Submaxillary gland androgen-regulated protein 3A (Proline-rich protein 5) (Proline-rich protein PBI)	SMR3A PBI PROL5	Homo sapiens (Human)	134	FUNCTION: May play a role in protection or detoxification. {ECO:0000250}.		regulation of sensory perception of pain [GO:0051930]	extracellular region [GO:0005576]	endopeptidase inhibitor activity [GO:0004866]	extracellular region [GO:0005576]; endopeptidase inhibitor activity [GO:0004866]; regulation of sensory perception of pain [GO:0051930]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BPW4	reviewed	APOL4_HUMAN	Apolipoprotein L4 (Apolipoprotein L-IV) (ApoL-IV)	APOL4	Homo sapiens (Human)	351	FUNCTION: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). {ECO:0000250}.		lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]	extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]	lipid binding [GO:0008289]	extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lipid binding [GO:0008289]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BPX5	reviewed	ARP5L_HUMAN	Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2)	ARPC5L	Homo sapiens (Human)	153	FUNCTION: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.		Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell migration [GO:0016477]; regulation of actin filament polymerization [GO:0030833]	Arp2/3 protein complex [GO:0005885]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]	actin filament binding [GO:0051015]	Arp2/3 protein complex [GO:0005885]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; actin filament binding [GO:0051015]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell migration [GO:0016477]; regulation of actin filament polymerization [GO:0030833]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q9BPY3	reviewed	F118B_HUMAN	Protein FAM118B	FAM118B	Homo sapiens (Human)	351	FUNCTION: May play a role in Cajal bodies formation. {ECO:0000269|PubMed:24569877}.	MISCELLANEOUS: Overexpression changes the morphology of Cajal bodies, while depletion disrupts the localization of components of Cajal bodies, reduces splicing capacity and inhibits cell proliferation. {ECO:0000269|PubMed:24569877}.		Cajal body [GO:0015030]	identical protein binding [GO:0042802]	Cajal body [GO:0015030]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Nucleus, Cajal body {ECO:0000269|PubMed:24569877}.
Q9BQ08	reviewed	RETNB_HUMAN	Resistin-like beta (Colon and small intestine-specific cysteine-rich protein) (Colon carcinoma-related gene protein) (Cysteine-rich secreted protein A12-alpha-like 1) (Cysteine-rich secreted protein FIZZ2) (RELMbeta)	RETNLB CCRG FIZZ2 HXCP2 RETNL2 UNQ408/PRO770	Homo sapiens (Human)	111	FUNCTION: Probable hormone.		epithelial cell proliferation [GO:0050673]	extracellular space [GO:0005615]	hormone activity [GO:0005179]	extracellular space [GO:0005615]; hormone activity [GO:0005179]; epithelial cell proliferation [GO:0050673]	SUBCELLULAR LOCATION: Secreted.
Q9BQC6	reviewed	RT63_HUMAN	Large ribosomal subunit protein mL63 (Mitochondrial ribosomal protein 63) (Mitochondrial ribosomal protein L57) (Ribosomal protein 63, mitochondrial) (hMRP63)	MRPL57 MRP63	Homo sapiens (Human)	102			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9BQI7	reviewed	PSD2_HUMAN	PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2)	PSD2 EFA6C	Homo sapiens (Human)	771			regulation of ARF protein signal transduction [GO:0032012]	cleavage furrow [GO:0032154]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]; ruffle membrane [GO:0032587]	guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543]	cleavage furrow [GO:0032154]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]; ruffle membrane [GO:0032587]; guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543]; regulation of ARF protein signal transduction [GO:0032012]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6P1I6}; Single-pass membrane protein {ECO:0000305}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q6P1I6}. Cleavage furrow {ECO:0000250|UniProtKB:Q6P1I6}. Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions. In cells undergoing cytokinesis, transiently found around the ingressing cleavage furrow. Not detected at the midbody ring/Flemming body. {ECO:0000250|UniProtKB:Q6P1I6}.
Q9BQI9	reviewed	NRIP2_HUMAN	Nuclear receptor-interacting protein 2	NRIP2	Homo sapiens (Human)	281	FUNCTION: Down-regulates transcriptional activation by nuclear receptors such as NR1F2. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	aspartic-type endopeptidase activity [GO:0004190]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; aspartic-type endopeptidase activity [GO:0004190]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9BQQ7	reviewed	RTP3_HUMAN	Receptor-transporting protein 3 (3CxxC-type zinc finger protein 3) (Transmembrane protein 7)	RTP3 TMEM7 Z3CXXC3	Homo sapiens (Human)	232	FUNCTION: Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43. {ECO:0000269|PubMed:16720576}.		detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612]	cytoplasm [GO:0005737]; membrane [GO:0016020]	metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849]	cytoplasm [GO:0005737]; membrane [GO:0016020]; metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Q9BQR3	reviewed	PRS27_HUMAN	Serine protease 27 (EC 3.4.21.-) (Marapsin) (Pancreasin)	PRSS27 MPN UNQ1884/PRO4327	Homo sapiens (Human)	290			proteolysis [GO:0006508]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted.
Q9BQS6	reviewed	HSPB9_HUMAN	Heat shock protein beta-9 (HspB9) (Cancer/testis antigen 51) (CT51)	HSPB9	Homo sapiens (Human)	159				cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus {ECO:0000269|PubMed:19464326}. Note=Translocates to nuclear foci during heat shock.
Q9BQY9	reviewed	DBND2_HUMAN	Dysbindin domain-containing protein 2 (Casein kinase-1 binding protein) (CK1BP) (HSMNP1)	DBNDD2 C20orf35	Homo sapiens (Human)	259	FUNCTION: May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro). {ECO:0000269|PubMed:16618118}.		negative regulation of protein kinase activity [GO:0006469]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of protein kinase activity [GO:0006469]	
Q9BR61	reviewed	ACBD6_HUMAN	Acyl-CoA-binding domain-containing protein 6	ACBD6	Homo sapiens (Human)	282	FUNCTION: Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. {ECO:0000269|PubMed:18268358}.			cytosol [GO:0005829]	fatty-acyl-CoA binding [GO:0000062]	cytosol [GO:0005829]; fatty-acyl-CoA binding [GO:0000062]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18268358}.
Q9BR84	reviewed	ZN559_HUMAN	Zinc finger protein 559	ZNF559	Homo sapiens (Human)	538	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BRJ2	reviewed	RM45_HUMAN	Large ribosomal subunit protein mL45 (39S ribosomal protein L45, mitochondrial) (L45mt) (MRP-L45)	MRPL45	Homo sapiens (Human)	306			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9BRP4	reviewed	PAAF1_HUMAN	Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71)	PAAF1 WDR71	Homo sapiens (Human)	392	FUNCTION: Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation. {ECO:0000269|PubMed:15831487, ECO:0000269|PubMed:17289585, ECO:0000269|PubMed:22316138}.		transcription initiation at RNA polymerase II promoter [GO:0006367]	proteasome complex [GO:0000502]; transcription factor TFIID complex [GO:0005669]		proteasome complex [GO:0000502]; transcription factor TFIID complex [GO:0005669]; transcription initiation at RNA polymerase II promoter [GO:0006367]	
Q9BRQ4	reviewed	CF300_HUMAN	Cilia- and flagella-associated protein 300	CFAP300 C11orf70	Homo sapiens (Human)	267	FUNCTION: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly. {ECO:0000250|UniProtKB:A0CY51}.			cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A0CY51}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A0CY51}.
Q9BRQ5	reviewed	ORAI3_HUMAN	Protein orai-3 (Transmembrane protein 142C)	ORAI3 TMEM142C	Homo sapiens (Human)	295	FUNCTION: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1. {ECO:0000269|PubMed:20354224}.		store-operated calcium entry [GO:0002115]	membrane [GO:0016020]; plasma membrane [GO:0005886]	store-operated calcium channel activity [GO:0015279]	membrane [GO:0016020]; plasma membrane [GO:0005886]; store-operated calcium channel activity [GO:0015279]; store-operated calcium entry [GO:0002115]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q9BRR8	reviewed	GPTC1_HUMAN	G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein)	GPATCH1 ECGP GPATC1	Homo sapiens (Human)	931			mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]	
Q9BRT6	reviewed	LLPH_HUMAN	Protein LLP homolog (Protein LAPS18-like)	LLPH C12orf31 cPERP-G	Homo sapiens (Human)	129	FUNCTION: In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission. {ECO:0000250|UniProtKB:Q9D945}.		dendrite extension [GO:0097484]; positive regulation of dendritic spine development [GO:0060999]	chromosome [GO:0005694]; nucleolus [GO:0005730]	basal RNA polymerase II transcription machinery binding [GO:0001099]; RNA binding [GO:0003723]	chromosome [GO:0005694]; nucleolus [GO:0005730]; basal RNA polymerase II transcription machinery binding [GO:0001099]; RNA binding [GO:0003723]; dendrite extension [GO:0097484]; positive regulation of dendritic spine development [GO:0060999]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9D945}. Chromosome {ECO:0000269|PubMed:20813266}. Note=Cell-permeable protein. 22 hours after injection in the hippocampal area CA1, internalized by most cells at the injection site (By similarity). Localizes at the chromosome periphery during mitosis (PubMed:20813266). {ECO:0000250|UniProtKB:Q9D945, ECO:0000269|PubMed:20813266}.
Q9BRU2	reviewed	TCAL7_HUMAN	Transcription elongation factor A protein-like 7 (TCEA-like protein 7) (Transcription elongation factor S-II protein-like 7)	TCEAL7	Homo sapiens (Human)	100	FUNCTION: Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines. {ECO:0000269|PubMed:18806825, ECO:0000269|PubMed:19966855, ECO:0000269|PubMed:20454512}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18806825}.
Q9BRY0	reviewed	S39A3_HUMAN	Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3)	SLC39A3 ZIP3	Homo sapiens (Human)	314	FUNCTION: Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen. {ECO:0000250|UniProtKB:Q99K24}.		cell morphogenesis [GO:0000902]; embryonic cranial skeleton morphogenesis [GO:0048701]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; T cell homeostasis [GO:0043029]; zinc ion transmembrane transport [GO:0071577]	apical plasma membrane [GO:0016324]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]	zinc ion transmembrane transporter activity [GO:0005385]	apical plasma membrane [GO:0016324]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; zinc ion transmembrane transporter activity [GO:0005385]; cell morphogenesis [GO:0000902]; embryonic cranial skeleton morphogenesis [GO:0048701]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; T cell homeostasis [GO:0043029]; zinc ion transmembrane transport [GO:0071577]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q99K24}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q99K24}; Multi-pass membrane protein {ECO:0000255}. Note=Localized primarily at the cell surface but also found in a perinuclear compartment in HC11 cells. In mammary epithelial cell, localized primary to the apical membrane. {ECO:0000250|UniProtKB:Q99K24}.
Q9BS18	reviewed	APC13_HUMAN	Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13)	ANAPC13	Homo sapiens (Human)	74	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:15060174, ECO:0000269|PubMed:18485873}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	anaphase-promoting complex [GO:0005680]		anaphase-promoting complex [GO:0005680]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BS31	reviewed	ZN649_HUMAN	Zinc finger protein 649	ZNF649	Homo sapiens (Human)	505	FUNCTION: Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways. {ECO:0000269|PubMed:15950191}.		regulation of transcription by RNA polymerase II [GO:0006357]	extracellular space [GO:0005615]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	extracellular space [GO:0005615]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15950191}.
Q9BSF4	reviewed	TIM29_HUMAN	Mitochondrial import inner membrane translocase subunit Tim29 (TIM29)	TIMM29 c19orf52	Homo sapiens (Human)	260	FUNCTION: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40. {ECO:0000269|PubMed:27554484, ECO:0000269|PubMed:27718247}.		protein insertion into mitochondrial inner membrane [GO:0045039]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]	protein transporter activity [GO:0140318]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]; protein transporter activity [GO:0140318]; protein insertion into mitochondrial inner membrane [GO:0045039]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:27554484, ECO:0000269|PubMed:27718247}; Single-pass membrane protein {ECO:0000305}; Intermembrane side {ECO:0000269|PubMed:27718247}.
Q9BSF8	reviewed	BTBDA_HUMAN	BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1)	BTBD10 GMRP1	Homo sapiens (Human)	475	FUNCTION: Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. {ECO:0000250|UniProtKB:Q80X66}.		phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of phosphorylation [GO:0042327]; type B pancreatic cell proliferation [GO:0044342]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]		cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]; positive regulation of phosphorylation [GO:0042327]; type B pancreatic cell proliferation [GO:0044342]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15556295}. Cytoplasm {ECO:0000250|UniProtKB:Q80X66}. Note=Colocalizes with KCTD20 in filamentous structures. {ECO:0000250|UniProtKB:Q80X66}.
Q9BSG0	reviewed	PADC1_HUMAN	Protease-associated domain-containing protein 1 (Protease-associated domain-containing protein of 21 kDa) (hPAP21)	PRADC1 C2orf7 PAP21 UNQ833/PRO1760	Homo sapiens (Human)	188	FUNCTION: Plays a role in the modulation of physical activity and adiposity. {ECO:0000250|UniProtKB:Q9D9N8}.			extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15498570}.
Q9BSG5	reviewed	RTBDN_HUMAN	Retbindin	RTBDN	Homo sapiens (Human)	229	FUNCTION: Riboflavin-binding protein which might have a role in retinal flavin transport. {ECO:0000250|UniProtKB:Q8QZY4}.			external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165]	riboflavin binding [GO:1902444]; riboflavin transmembrane transporter activity [GO:0032217]; signaling receptor activity [GO:0038023]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165]; riboflavin binding [GO:1902444]; riboflavin transmembrane transporter activity [GO:0032217]; signaling receptor activity [GO:0038023]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix {ECO:0000250|UniProtKB:Q8QZY4}. Cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8QZY4}.
Q9BSH3	reviewed	NICN1_HUMAN	Nicolin-1 (NPCEDRG) (Tubulin polyglutamylase complex subunit 5) (PGs5)	NICN1	Homo sapiens (Human)	213				microtubule [GO:0005874]; nucleoplasm [GO:0005654]		microtubule [GO:0005874]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12392556}.
Q9BSH5	reviewed	HDHD3_HUMAN	Haloacid dehalogenase-like hydrolase domain-containing protein 3	HDHD3 C9orf158	Homo sapiens (Human)	251				intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]		intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]	
Q9BSJ5	reviewed	CQ080_HUMAN	Uncharacterized protein C17orf80 (Cell migration-inducing gene 3 protein) (Human lung cancer oncogene 8 protein) (HLC-8)	C17orf80 HLC8 MIG3	Homo sapiens (Human)	609				extracellular exosome [GO:0070062]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9BSK1	reviewed	ZN577_HUMAN	Zinc finger protein 577	ZNF577	Homo sapiens (Human)	485	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BSN7	reviewed	TM204_HUMAN	Transmembrane protein 204 (Claudin-like protein 24)	TMEM204 C16orf30 CLP24 UNQ6509/PRO21434	Homo sapiens (Human)	226	FUNCTION: Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens.		lymph vessel development [GO:0001945]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; smooth muscle cell differentiation [GO:0051145]	adherens junction [GO:0005912]; plasma membrane [GO:0005886]		adherens junction [GO:0005912]; plasma membrane [GO:0005886]; lymph vessel development [GO:0001945]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; smooth muscle cell differentiation [GO:0051145]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:15206924}. Cell membrane {ECO:0000269|PubMed:15206924}; Multi-pass membrane protein {ECO:0000269|PubMed:15206924}. Note=Colocalizes with the beta-catenin adherins.
Q9BT76	reviewed	UPK3B_HUMAN	Uroplakin-3b (UP3b) (Uroplakin IIIb) (UPIIIb) (p35)	UPK3B	Homo sapiens (Human)	320	FUNCTION: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). {ECO:0000250}.		negative regulation of gene expression [GO:0010629]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; negative regulation of gene expression [GO:0010629]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000269|PubMed:12446744}.
Q9BTM1	reviewed	H2AJ_HUMAN	Histone H2A.J (H2a/j)	H2AJ H2AFJ	Homo sapiens (Human)	129	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.			extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Q9BTT6	reviewed	LRRC1_HUMAN	Leucine-rich repeat-containing protein 1 (LANO adapter protein) (LAP and no PDZ protein)	LRRC1 LANO	Homo sapiens (Human)	524				cytosol [GO:0005829]; membrane [GO:0016020]		cytosol [GO:0005829]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11440998}. Membrane {ECO:0000269|PubMed:11440998}; Peripheral membrane protein {ECO:0000269|PubMed:11440998}. Note=Localized at the basolateral side of epithelial cells.
Q9BTV6	reviewed	DPH7_HUMAN	Diphthine methyltransferase (EC 3.1.1.97) (Diphthamide biosynthesis protein 7) (WD repeat-containing protein 85)	DPH7 C9orf112 WDR85	Homo sapiens (Human)	452	FUNCTION: Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250|UniProtKB:P38332, ECO:0000269|PubMed:19965467, ECO:0000269|PubMed:23486472}.		protein histidyl modification to diphthamide [GO:0017183]	cytoplasm [GO:0005737]	diphthine methylesterase activity [GO:0061685]	cytoplasm [GO:0005737]; diphthine methylesterase activity [GO:0061685]; protein histidyl modification to diphthamide [GO:0017183]	
Q9BU23	reviewed	LMF2_HUMAN	Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153)	LMF2 TMEM112B TMEM153	Homo sapiens (Human)	707	FUNCTION: Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity). {ECO:0000250}.		protein maturation [GO:0051604]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]		endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; protein maturation [GO:0051604]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9BU70	reviewed	TRMO_HUMAN	tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O)	TRMO C9orf156 HSPC219	Homo sapiens (Human)	441	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability (By similarity). {ECO:0000250|UniProtKB:P28634, ECO:0000269|PubMed:25063302}.		tRNA methylation [GO:0030488]		tRNA m6t6A37 methyltransferase activity [GO:0089715]	tRNA m6t6A37 methyltransferase activity [GO:0089715]; tRNA methylation [GO:0030488]	
Q9BUG6	reviewed	ZSA5A_HUMAN	Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495)	ZSCAN5A ZNF495 ZSCAN5	Homo sapiens (Human)	496	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q9BUK0	reviewed	CHCH7_HUMAN	Coiled-coil-helix-coiled-coil-helix domain-containing protein 7	CHCHD7	Homo sapiens (Human)	85			mitochondrial respiratory chain complex assembly [GO:0033108]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]		mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; mitochondrial respiratory chain complex assembly [GO:0033108]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000305}.
Q9BUN1	reviewed	MENT_HUMAN	Protein MENT (Methylated in normal thymocytes protein)	MENT C1orf56 UNQ547/PRO1104	Homo sapiens (Human)	341	FUNCTION: Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B. {ECO:0000269|PubMed:22133874}.		regulation of cell population proliferation [GO:0042127]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BUT9	reviewed	MCRI2_HUMAN	MAPK regulated corepressor interacting protein 2 (Protein FAM195A)	MCRIP2 C16orf14 FAM195A	Homo sapiens (Human)	160		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm, Stress granule {ECO:0000269|PubMed:26184334}. Nucleus {ECO:0000269|PubMed:26184334}.
Q9BV19	reviewed	CA050_HUMAN	Uncharacterized protein C1orf50	C1orf50	Homo sapiens (Human)	199					identical protein binding [GO:0042802]	identical protein binding [GO:0042802]	
Q9BV99	reviewed	LRC61_HUMAN	Leucine-rich repeat-containing protein 61	LRRC61	Homo sapiens (Human)	259			outer dynein arm assembly [GO:0036158]	cytoplasm [GO:0005737]	alpha-tubulin binding [GO:0043014]; dynein heavy chain binding [GO:0045504]	cytoplasm [GO:0005737]; alpha-tubulin binding [GO:0043014]; dynein heavy chain binding [GO:0045504]; outer dynein arm assembly [GO:0036158]	
Q9BVC5	reviewed	ASHWN_HUMAN	Ashwin	C2orf49	Homo sapiens (Human)	232			embryonic morphogenesis [GO:0048598]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669]		cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669]; embryonic morphogenesis [GO:0048598]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18445686}.
Q9BW30	reviewed	TPPP3_HUMAN	Tubulin polymerization-promoting protein family member 3 (TPPP/p20)	TPPP3 CGI-38	Homo sapiens (Human)	176	FUNCTION: Regulator of microtubule dynamic that has microtubule bundling activity (PubMed:17105200, PubMed:19633818). Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin (PubMed:30667362). {ECO:0000250|UniProtKB:Q9CRB6, ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:19633818, ECO:0000269|PubMed:30667362}.		decidualization [GO:0046697]; embryo implantation [GO:0007566]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; positive regulation of protein polymerization [GO:0032273]	cytoplasm [GO:0005737]; microtubule [GO:0005874]	tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; tubulin binding [GO:0015631]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; positive regulation of protein polymerization [GO:0032273]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30667362}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:17105200}.
Q9BW72	reviewed	HIG2A_HUMAN	HIG1 domain family member 2A, mitochondrial (RCF1 homolog B) (RCF1b)	HIGD2A	Homo sapiens (Human)	106	FUNCTION: Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269|PubMed:22342701}.		mitochondrial respirasome assembly [GO:0097250]; negative regulation of apoptotic process [GO:0043066]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respirasome [GO:0070469]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respirasome [GO:0070469]; mitochondrial respirasome assembly [GO:0097250]; negative regulation of apoptotic process [GO:0043066]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000255|PROSITE-ProRule:PRU00836, ECO:0000269|PubMed:22342701}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00836, ECO:0000269|PubMed:22342701}. Mitochondrion inner membrane {ECO:0000305|PubMed:22342701}.
Q9BWU0	reviewed	NADAP_HUMAN	Kanadaptin (Human lung cancer oncogene 3 protein) (HLC-3) (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein)	SLC4A1AP HLC3	Homo sapiens (Human)	796				cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; mRNA binding [GO:0003729]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15764369}. Cytoplasm {ECO:0000269|PubMed:15764369}. Note=Mainly nuclear. Small amounts are found in the cytoplasm.
Q9BWW8	reviewed	APOL6_HUMAN	Apolipoprotein L6 (Apolipoprotein L-VI) (ApoL-VI)	APOL6 UNQ3095/PRO21341	Homo sapiens (Human)	343	FUNCTION: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.		lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	lipid binding [GO:0008289]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; lipid binding [GO:0008289]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q9BX82	reviewed	ZN471_HUMAN	Zinc finger protein 471 (EZFIT-related protein 1)	ZNF471 ERP1 KIAA1396	Homo sapiens (Human)	626	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BX93	reviewed	PG12B_HUMAN	Group XIIB secretory phospholipase A2-like protein (Group XIII secretory phospholipase A2-like protein) (GXIII sPLA2-like) (sPLA2-GXIIB) (GXIIB)	PLA2G12B PLA2G13 FKSG71	Homo sapiens (Human)	195	FUNCTION: Not known; does not seem to have catalytic activity.		arachidonic acid secretion [GO:0050482]; cholesterol homeostasis [GO:0042632]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644]; triglyceride homeostasis [GO:0070328]	extracellular region [GO:0005576]	calcium ion binding [GO:0005509]; phospholipase A2 activity [GO:0004623]	extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; phospholipase A2 activity [GO:0004623]; arachidonic acid secretion [GO:0050482]; cholesterol homeostasis [GO:0042632]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644]; triglyceride homeostasis [GO:0070328]	SUBCELLULAR LOCATION: Secreted.
Q9BXA9	reviewed	SALL3_HUMAN	Sal-like protein 3 (Zinc finger protein 796) (Zinc finger protein SALL3) (hSALL3)	SALL3 ZNF796	Homo sapiens (Human)	1300	FUNCTION: Probable transcription factor.	MISCELLANEOUS: [Isoform 1]: Lacks two zinc finger domains. Major isoform with isoform 2. {ECO:0000305}.; MISCELLANEOUS: [Isoform 2]: Lacks two zinc finger domains. Major isoform with isoform 1. {ECO:0000305}.	regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BXC1	reviewed	GP174_HUMAN	Probable G-protein coupled receptor 174	GPR174 FKSG79 GPCR17	Homo sapiens (Human)	333	FUNCTION: Putative receptor for purines coupled to G-proteins. {ECO:0000250}.		phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]; T cell homeostasis [GO:0043029]	centriolar satellite [GO:0034451]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	bioactive lipid receptor activity [GO:0045125]; G protein-coupled receptor activity [GO:0004930]	centriolar satellite [GO:0034451]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; bioactive lipid receptor activity [GO:0045125]; G protein-coupled receptor activity [GO:0004930]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]; T cell homeostasis [GO:0043029]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9BXG8	reviewed	SPZ1_HUMAN	Spermatogenic leucine zipper protein 1 (Testis-specific protein 1) (Testis-specific protein NYD-TSP1)	SPZ1 TSP1	Homo sapiens (Human)	430	FUNCTION: Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity). {ECO:0000250}.	MISCELLANEOUS: The helix-loop-helix and basic motifs form a SPZ1 specific bHLH different from the classical one. {ECO:0000250}.		cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q9BXK1	reviewed	KLF16_HUMAN	Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2)	KLF16 BTEB4 NSLP2	Homo sapiens (Human)	252	FUNCTION: Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}.		dopamine receptor signaling pathway [GO:0007212]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; dopamine receptor signaling pathway [GO:0007212]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9BXL5	reviewed	HEMGN_HUMAN	Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein)	HEMGN EDAG NDR PRO1037 PRO1620	Homo sapiens (Human)	484	FUNCTION: Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). {ECO:0000269|PubMed:14730214, ECO:0000269|PubMed:15332117, ECO:0000269|PubMed:15920494}.		cell differentiation [GO:0030154]; regulation of osteoblast differentiation [GO:0045667]	nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]; cell differentiation [GO:0030154]; regulation of osteoblast differentiation [GO:0045667]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14730214}.
Q9BXT2	reviewed	CCG6_HUMAN	Voltage-dependent calcium channel gamma-6 subunit (Neuronal voltage-gated calcium channel gamma-6 subunit)	CACNG6	Homo sapiens (Human)	260	FUNCTION: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. {ECO:0000269|PubMed:21127204}.		calcium ion transport [GO:0006816]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]	L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]	calcium channel regulator activity [GO:0005246]; voltage-gated calcium channel activity [GO:0005245]	L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; calcium channel regulator activity [GO:0005246]; voltage-gated calcium channel activity [GO:0005245]; calcium ion transport [GO:0006816]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:21127204}; Multi-pass membrane protein {ECO:0000305}.
Q9BY21	reviewed	GPR87_HUMAN	G-protein coupled receptor 87 (G-protein coupled receptor 95)	GPR87 GPR95 FKSG78	Homo sapiens (Human)	358	FUNCTION: Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. {ECO:0000269|PubMed:17905198, ECO:0000269|PubMed:19602589}.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled purinergic nucleotide receptor activity [GO:0045028]	plasma membrane [GO:0005886]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9BY60	reviewed	GBRL3_HUMAN	Gamma-aminobutyric acid receptor-associated protein-like 3 (GABA(A) receptor-associated protein-like 3)	GABARAPL3	Homo sapiens (Human)	117	FUNCTION: Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). {ECO:0000250}.		autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; macroautophagy [GO:0016236]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; microtubule [GO:0005874]	GABA receptor binding [GO:0050811]; ubiquitin protein ligase binding [GO:0031625]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; microtubule [GO:0005874]; GABA receptor binding [GO:0050811]; ubiquitin protein ligase binding [GO:0031625]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995]; macroautophagy [GO:0016236]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Q9BYC2	reviewed	SCOT2_HUMAN	Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 2A) (Testis-specific succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-t)	OXCT2 FKSG25	Homo sapiens (Human)	517	FUNCTION: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). {ECO:0000250}.		cellular ketone body metabolic process [GO:0046950]; ketone body catabolic process [GO:0046952]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]	succinyl-CoA:3-oxo-acid CoA-transferase activity [GO:0008260]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; succinyl-CoA:3-oxo-acid CoA-transferase activity [GO:0008260]; cellular ketone body metabolic process [GO:0046950]; ketone body catabolic process [GO:0046952]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11756565}.
Q9BYC8	reviewed	RM32_HUMAN	Large ribosomal subunit protein bL32m (39S ribosomal protein L32, mitochondrial) (L32mt) (MRP-L32)	MRPL32 HSPC283	Homo sapiens (Human)	188			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9BYC9	reviewed	RM20_HUMAN	Large ribosomal subunit protein bL20m (39S ribosomal protein L20, mitochondrial) (L20mt) (MRP-L20)	MRPL20	Homo sapiens (Human)	149			mitochondrial translation [GO:0032543]; ribosomal large subunit assembly [GO:0000027]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; ribosomal large subunit assembly [GO:0000027]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279069, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9BYD1	reviewed	RM13_HUMAN	Large ribosomal subunit protein uL13m (39S ribosomal protein L13, mitochondrial) (L13mt) (MRP-L13)	MRPL13	Homo sapiens (Human)	178			mitochondrial translation [GO:0032543]; negative regulation of translation [GO:0017148]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; ribosome [GO:0005840]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; ribosome [GO:0005840]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; negative regulation of translation [GO:0017148]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9BYD2	reviewed	RM09_HUMAN	Large ribosomal subunit protein bL9m (39S ribosomal protein L9, mitochondrial) (L9mt) (MRP-L9)	MRPL9	Homo sapiens (Human)	267			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9BYD3	reviewed	RM04_HUMAN	Large ribosomal subunit protein uL4m (39S ribosomal protein L4, mitochondrial) (L4mt) (MRP-L4)	MRPL4 CDABP0091 CGI-28	Homo sapiens (Human)	311			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9BYN8	reviewed	RT26_HUMAN	Small ribosomal subunit protein mS26 (28S ribosomal protein S13, mitochondrial) (MRP-S13) (S13mt) (28S ribosomal protein S26, mitochondrial) (MRP-S26) (S26mt)	MRPS26 C20orf193 RPMS13	Homo sapiens (Human)	205			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
Q9BYQ8	reviewed	KRA49_HUMAN	Keratin-associated protein 4-9 (Keratin-associated protein 4.9) (Ultrahigh sulfur keratin-associated protein 4.9)	KRTAP4-9 KAP4.9 KRTAP4.9	Homo sapiens (Human)	210	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.		hair cycle [GO:0042633]	cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]; hair cycle [GO:0042633]	
Q9BYQ9	reviewed	KRA48_HUMAN	Keratin-associated protein 4-8 (Keratin-associated protein 4.8) (Ultrahigh sulfur keratin-associated protein 4.8)	KRTAP4-8 KAP4.8 KRTAP4.8	Homo sapiens (Human)	185	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.		hair cycle [GO:0042633]	cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]; hair cycle [GO:0042633]	
Q9BZ76	reviewed	CNTP3_HUMAN	Contactin-associated protein-like 3 (Cell recognition molecule Caspr3)	CNTNAP3 CASPR3 KIAA1714	Homo sapiens (Human)	1288			cell adhesion [GO:0007155]; cell recognition [GO:0008037]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cell adhesion [GO:0007155]; cell recognition [GO:0008037]	SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Q9BZD7	reviewed	TMG3_HUMAN	Transmembrane gamma-carboxyglutamic acid protein 3 (Proline-rich gamma-carboxyglutamic acid protein 3) (Proline-rich Gla protein 3)	PRRG3 PRGP3 TMG3	Homo sapiens (Human)	231				extracellular space [GO:0005615]; membrane [GO:0016020]	calcium ion binding [GO:0005509]	extracellular space [GO:0005615]; membrane [GO:0016020]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9BZE1	reviewed	RM37_HUMAN	Large ribosomal subunit protein mL37 (39S ribosomal protein L2, mitochondrial) (L2mt) (MRP-L2) (39S ribosomal protein L37, mitochondrial) (L37mt) (MRP-L37)	MRPL37 MRPL2 RPML2 HSPC235	Homo sapiens (Human)	423			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9BZI1	reviewed	IRX2_HUMAN	Iroquois-class homeodomain protein IRX-2 (Homeodomain protein IRXA2) (Iroquois homeobox protein 2)	IRX2 IRXA2	Homo sapiens (Human)	471			cell development [GO:0048468]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; proximal/distal pattern formation involved in metanephric nephron development [GO:0072272]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of loop of Henle identity [GO:0072086]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; cell development [GO:0048468]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; proximal/distal pattern formation involved in metanephric nephron development [GO:0072272]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of loop of Henle identity [GO:0072086]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q9BZJ4	reviewed	S2539_HUMAN	Probable mitochondrial glutathione transporter SLC25A39 (Solute carrier family 25 member 39)	SLC25A39 CGI-69 PRO2163	Homo sapiens (Human)	359	FUNCTION: Mitochondrial transporter required for glutathione import into mitochondria (PubMed:34707288, PubMed:35513392). Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (PubMed:34707288). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis (PubMed:34707288). {ECO:0000269|PubMed:34707288, ECO:0000269|PubMed:35513392}.		glutathione import into mitochondrion [GO:0160007]; heme biosynthetic process [GO:0006783]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; glutathione import into mitochondrion [GO:0160007]; heme biosynthetic process [GO:0006783]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11139402, ECO:0000269|PubMed:11256614}; Multi-pass membrane protein {ECO:0000255}.
Q9BZJ6	reviewed	GPR63_HUMAN	Probable G-protein coupled receptor 63 (PSP24-2) (PSP24-beta)	GPR63 PSP24B	Homo sapiens (Human)	419	FUNCTION: Orphan receptor. May play a role in brain function.		G protein-coupled receptor signaling pathway [GO:0007186]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled receptor activity [GO:0004930]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9C009	reviewed	FOXQ1_HUMAN	Forkhead box protein Q1 (HNF-3/forkhead-like protein 1) (HFH-1) (Hepatocyte nuclear factor 3 forkhead homolog 1)	FOXQ1 HFH1	Homo sapiens (Human)	403	FUNCTION: Plays a role in hair follicle differentiation. {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; hair follicle morphogenesis [GO:0031069]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; hair follicle morphogenesis [GO:0031069]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Q9C010	reviewed	IPKB_HUMAN	cAMP-dependent protein kinase inhibitor beta (PKI-beta)	PKIB PRKACN2	Homo sapiens (Human)	78	FUNCTION: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. {ECO:0000250}.		positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	cAMP-dependent protein kinase inhibitor activity [GO:0004862]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]	
Q9C075	reviewed	K1C23_HUMAN	Keratin, type I cytoskeletal 23 (Cytokeratin-23) (CK-23) (Keratin-23) (K23)	KRT23	Homo sapiens (Human)	422		MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).	epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882]	structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]	
Q9C099	reviewed	LRCC1_HUMAN	Leucine-rich repeat and coiled-coil domain-containing protein 1 (Centrosomal leucine-rich repeat and coiled-coil domain-containing protein)	LRRCC1 CLERC KIAA1764	Homo sapiens (Human)	1032	FUNCTION: Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis. {ECO:0000269|PubMed:18728398}.		cell cycle [GO:0007049]; cell division [GO:0051301]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]		centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cell cycle [GO:0007049]; cell division [GO:0051301]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:18728398}. Note=Associates with the centrosome throughout the cell cycle and extensively accumulates during the mitotic phase.
Q9C0B6	reviewed	BRNP2_HUMAN	BMP/retinoic acid-inducible neural-specific protein 2 (DBCCR1-like protein 2)	BRINP2 DBCCR1L2 FAM5B KIAA1747	Homo sapiens (Human)	783	FUNCTION: Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. {ECO:0000250}.		cell cycle [GO:0007049]; cellular response to retinoic acid [GO:0071300]; central nervous system neuron differentiation [GO:0021953]; negative regulation of mitotic cell cycle [GO:0045930]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]		cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; cell cycle [GO:0007049]; cellular response to retinoic acid [GO:0071300]; central nervous system neuron differentiation [GO:0021953]; negative regulation of mitotic cell cycle [GO:0045930]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9C0D7	reviewed	ZC12C_HUMAN	Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C)	ZC3H12C KIAA1726 MCPIP3	Homo sapiens (Human)	883	FUNCTION: May function as RNase and regulate the levels of target RNA species. {ECO:0000305}.			cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521]	
Q9C0H5	reviewed	RHG39_HUMAN	Rho GTPase-activating protein 39	ARHGAP39 KIAA1688	Homo sapiens (Human)	1083			postsynapse organization [GO:0099173]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; GTPase activator activity [GO:0005096]; postsynapse organization [GO:0099173]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9GZK4	reviewed	OR2H1_HUMAN	Olfactory receptor 2H1 (Hs6M1-16) (OLFR42A-9004.14/9026.2) (Olfactory receptor 2H6) (Olfactory receptor 2H8) (Olfactory receptor 6-2) (OR6-2) (Olfactory receptor OR6-32)	OR2H1 OR2H6 OR2H8	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9GZK6	reviewed	OR2J1_HUMAN	Olfactory receptor 2J1 (Hs6M1-4) (Olfactory receptor 6-5) (OR6-5)	OR2J1 OR2J1P	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9GZM6	reviewed	OR8D2_HUMAN	Olfactory receptor 8D2 (Olfactory receptor OR11-303) (Olfactory receptor-like protein JCG2)	OR8D2	Homo sapiens (Human)	311	FUNCTION: Odorant receptor (Potential). May be involved in taste perception. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9GZN6	reviewed	S6A16_HUMAN	Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 (Solute carrier family 6 member 16)	SLC6A16 NTT5	Homo sapiens (Human)	736			neurotransmitter transport [GO:0006836]; nitrogen compound transport [GO:0071705]; organic substance transport [GO:0071702]; sodium ion transmembrane transport [GO:0035725]	membrane [GO:0016020]	neurotransmitter transmembrane transporter activity [GO:0005326]; symporter activity [GO:0015293]	membrane [GO:0016020]; neurotransmitter transmembrane transporter activity [GO:0005326]; symporter activity [GO:0015293]; neurotransmitter transport [GO:0006836]; nitrogen compound transport [GO:0071705]; organic substance transport [GO:0071702]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9GZP4	reviewed	PITH1_HUMAN	PITH domain-containing protein 1	PITHD1 C1orf128 AD039 HT014 PP603	Homo sapiens (Human)	211	FUNCTION: Promotes megakaryocyte differentiation by up-regulating RUNX1 expression (PubMed:25134913). Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene (PubMed:25134913). {ECO:0000269|PubMed:25134913}.		penetration of cumulus oophorus [GO:0061956]; penetration of zona pellucida [GO:0007341]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of proteasomal protein catabolic process [GO:0061136]; spermatid development [GO:0007286]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm cytoplasmic droplet [GO:0097598]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm cytoplasmic droplet [GO:0097598]; penetration of cumulus oophorus [GO:0061956]; penetration of zona pellucida [GO:0007341]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of proteasomal protein catabolic process [GO:0061136]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25134913}.
Q9GZP7	reviewed	VN1R1_HUMAN	Vomeronasal type-1 receptor 1 (G-protein coupled receptor GPCR24) (hGPCR24) (V1r-like receptor 1) (V3r-related gene protein) (Vomeronasal olfactory receptor chromosome 19 subtype I member 1)	VN1R1 V1RL1 VNR19I1	Homo sapiens (Human)	353	FUNCTION: Putative pheromone receptor.	MISCELLANEOUS: The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.	response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606]	plasma membrane [GO:0005886]	pheromone receptor activity [GO:0016503]	plasma membrane [GO:0005886]; pheromone receptor activity [GO:0016503]; response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9GZQ3	reviewed	COMD5_HUMAN	COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG)	COMMD5 HT002	Homo sapiens (Human)	224	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966). {ECO:0000250|UniProtKB:Q9ERR2, ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.			cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
Q9GZR7	reviewed	DDX24_HUMAN	ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24)	DDX24	Homo sapiens (Human)	859	FUNCTION: ATP-dependent RNA helicase. {ECO:0000305}.		RNA metabolic process [GO:0016070]	membrane [GO:0016020]; nucleolus [GO:0005730]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	membrane [GO:0016020]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA metabolic process [GO:0016070]	
Q9GZT6	reviewed	CC90B_HUMAN	Coiled-coil domain-containing protein 90B, mitochondrial	CCDC90B CUA003 MDS011 MDS025	Homo sapiens (Human)	254				mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]		mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:11256614}; Single-pass membrane protein {ECO:0000255}.
Q9GZY4	reviewed	COA1_HUMAN	Cytochrome c oxidase assembly factor 1 homolog (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa)	COA1 C7orf44 MITRAC15	Homo sapiens (Human)	146	FUNCTION: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV (PubMed:23260140). As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I (PubMed:32320651). {ECO:0000269|PubMed:23260140, ECO:0000269|PubMed:32320651}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex I assembly [GO:0032981]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex I assembly [GO:0032981]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:22356826, ECO:0000269|PubMed:23260140}; Single-pass membrane protein {ECO:0000269|PubMed:22356826, ECO:0000269|PubMed:23260140}.
Q9GZZ0	reviewed	HXD1_HUMAN	Homeobox protein Hox-D1 (Homeobox protein Hox-GG)	HOXD1 HOX4 HOX4G	Homo sapiens (Human)	328	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.		embryonic skeletal system development [GO:0048706]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of pain [GO:0019233]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; embryonic skeletal system development [GO:0048706]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of pain [GO:0019233]	SUBCELLULAR LOCATION: Nucleus.
Q9H009	reviewed	NACA2_HUMAN	Nascent polypeptide-associated complex subunit alpha-2 (Alpha-NAC-like) (Hom s 2.01) (Nascent polypeptide-associated complex subunit alpha-like) (NAC-alpha-like)	NACA2 NACAL	Homo sapiens (Human)	215	FUNCTION: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}.	MISCELLANEOUS: NACAL arose from a recent (40-63 million-year-old), anthropoid primate-specific retroduplication of NACA.	protein targeting to membrane [GO:0006612]	cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]	unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]; unfolded protein binding [GO:0051082]; protein targeting to membrane [GO:0006612]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q9H019	reviewed	MFR1L_HUMAN	Mitochondrial fission regulator 1-like	MTFR1L FAM54B HYST1888 MSTP116	Homo sapiens (Human)	292			aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266]	
Q9H061	reviewed	T126A_HUMAN	Transmembrane protein 126A	TMEM126A	Homo sapiens (Human)	195			mitochondrial respiratory chain complex I assembly [GO:0032981]; optic nerve development [GO:0021554]; toll-like receptor 4 signaling pathway [GO:0034142]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; mitochondrial respiratory chain complex I assembly [GO:0032981]; optic nerve development [GO:0021554]; toll-like receptor 4 signaling pathway [GO:0034142]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:19327736, ECO:0000269|PubMed:23500070}; Multi-pass membrane protein {ECO:0000269|PubMed:19327736, ECO:0000269|PubMed:23500070}.
Q9H069	reviewed	DRC3_HUMAN	Dynein regulatory complex subunit 3 (Leucine-rich repeat-containing protein 48)	DRC3 LRRC48	Homo sapiens (Human)	523	FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. {ECO:0000250|UniProtKB:A8IVX2}.			axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]		axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23354437}. Cell projection, cilium {ECO:0000269|PubMed:27120127}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8IVX2}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D5E4}.
Q9H091	reviewed	ZMY15_HUMAN	Zinc finger MYND domain-containing protein 15	ZMYND15	Homo sapiens (Human)	742	FUNCTION: Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis. {ECO:0000250|UniProtKB:Q8C0R7, ECO:0000303|PubMed:24431330}.		negative regulation of DNA-templated transcription [GO:0045892]; spermatid development [GO:0007286]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]	histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; negative regulation of DNA-templated transcription [GO:0045892]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q9H094	reviewed	NBPF3_HUMAN	Neuroblastoma breakpoint family member 3 (Protein AE2) (Protein SHIIIa4)	NBPF3 L7	Homo sapiens (Human)	633		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q9H0C3	reviewed	TM117_HUMAN	Transmembrane protein 117	TMEM117	Homo sapiens (Human)	514	FUNCTION: Involved in endoplasmic reticulum (ER) stress-induced cell death pathway. {ECO:0000269|PubMed:28285135}.		intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]		endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27391701}; Multi-pass membrane protein {ECO:0000255}.
Q9H0I3	reviewed	CC113_HUMAN	Coiled-coil domain-containing protein 113	CCDC113 HSPC065	Homo sapiens (Human)	377	FUNCTION: Component of centriolar satellites contributing to primary cilium formation. {ECO:0000269|PubMed:25074808}.		cilium assembly [GO:0060271]	axoneme [GO:0005930]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; protein-containing complex [GO:0032991]		axoneme [GO:0005930]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; protein-containing complex [GO:0032991]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:25074808}. Note=Colocalized with HAP1 at centriolar satellites. Centriolar satellite localization requires PCM1. {ECO:0000269|PubMed:25074808}.
Q9H0I9	reviewed	TKTL2_HUMAN	Transketolase-like protein 2 (EC 2.2.1.1)	TKTL2	Homo sapiens (Human)	626	FUNCTION: Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis. {ECO:0000269|PubMed:17321041}.			cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802]	
Q9H0U9	reviewed	TSYL1_HUMAN	Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1)	TSPYL1 TSPYL	Homo sapiens (Human)	437			nucleosome assembly [GO:0006334]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone binding [GO:0042393]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Q9H0V1	reviewed	TM168_HUMAN	Transmembrane protein 168	TMEM168	Homo sapiens (Human)	697	FUNCTION: Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A (PubMed:32175648). May play a role in the modulation of anxiety behavior by regulating GABAergic neuronal system in the nucleus accumbens (By similarity). {ECO:0000250|UniProtKB:Q91VX9, ECO:0000269|PubMed:32175648}.		regulation of ubiquitin-dependent protein catabolic process [GO:2000058]	nuclear membrane [GO:0031965]; transport vesicle [GO:0030133]	sodium channel regulator activity [GO:0017080]	nuclear membrane [GO:0031965]; transport vesicle [GO:0030133]; sodium channel regulator activity [GO:0017080]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:32175648}; Multi-pass membrane protein {ECO:0000255}.
Q9H0X4	reviewed	F234A_HUMAN	Protein FAM234A (Protein ITFG3)	FAM234A C16orf9 ITFG3	Homo sapiens (Human)	552				cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]		cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9H158	reviewed	PCDC1_HUMAN	Protocadherin alpha-C1 (PCDH-alpha-C1)	PCDHAC1	Homo sapiens (Human)	963	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9H175	reviewed	CSRN2_HUMAN	Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12)	CSRNP2 C12orf22 FAM130A1 TAIP12	Homo sapiens (Human)	543	FUNCTION: Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis. {ECO:0000250}.		apoptotic process [GO:0006915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; phosphatase binding [GO:0019902]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; phosphatase binding [GO:0019902]; sequence-specific DNA binding [GO:0043565]; apoptotic process [GO:0006915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9H1A3	reviewed	METL9_HUMAN	Protein-L-histidine N-pros-methyltransferase (EC 2.1.1.-) (DORA reverse strand protein) (DREV) (DREV1) (Methyltransferase-like protein 9) (hMETTL9)	METTL9 DREV CGI-81	Homo sapiens (Human)	318	FUNCTION: Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34562450). Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid) (PubMed:33563959). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (PubMed:33563959, PubMed:34562450). Constitutes the main methyltransferase for the 1-methylhistidine modification in cell (PubMed:33563959). {ECO:0000269|PubMed:33563959, ECO:0000269|PubMed:34562450}.		methylation [GO:0032259]	endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]	protein-L-histidine N-pros-methyltransferase activity [GO:0106370]	endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; protein-L-histidine N-pros-methyltransferase activity [GO:0106370]; methylation [GO:0032259]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:34562450, ECO:0000305|PubMed:33563959}. Mitochondrion {ECO:0000305|PubMed:33563959}. Note=Colocalizes with membranous compartments such as the endoplasmic reticulum and mitochondria. {ECO:0000269|PubMed:33563959}.
Q9H1C0	reviewed	LPAR5_HUMAN	Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (G-protein coupled receptor 93)	LPAR5 GPR92 GPR93	Homo sapiens (Human)	372	FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.		behavioral response to pain [GO:0048266]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; behavioral response to pain [GO:0048266]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H1U4	reviewed	MEGF9_HUMAN	Multiple epidermal growth factor-like domains protein 9 (Multiple EGF-like domains protein 9) (Epidermal growth factor-like protein 5) (EGF-like protein 5)	MEGF9 EGFL5 KIAA0818 UNQ671/PRO1305	Homo sapiens (Human)	602			regulation of actin filament polymerization [GO:0030833]	basement membrane [GO:0005604]; cytoplasm [GO:0005737]; membrane [GO:0016020]	small GTPase binding [GO:0031267]	basement membrane [GO:0005604]; cytoplasm [GO:0005737]; membrane [GO:0016020]; small GTPase binding [GO:0031267]; regulation of actin filament polymerization [GO:0030833]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9H1Z8	reviewed	AUGN_HUMAN	Augurin (Esophageal cancer-related gene 4 protein) (ECRG4)	ECRG4 C2orf40 UNQ761/PRO1508	Homo sapiens (Human)	148	FUNCTION: Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:D4A540}.		anaphase-promoting complex-dependent catabolic process [GO:0031145]; cellular senescence [GO:0090398]; central nervous system development [GO:0007417]; G1 to G0 transition [GO:0070314]; regulation of cell population proliferation [GO:0042127]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]		apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cellular senescence [GO:0090398]; central nervous system development [GO:0007417]; G1 to G0 transition [GO:0070314]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21349154}. Cytoplasm {ECO:0000269|PubMed:21349154}. Apical cell membrane {ECO:0000269|PubMed:21349154}.
Q9H1Z9	reviewed	TSN10_HUMAN	Tetraspanin-10 (Tspan-10) (Oculospanin)	TSPAN10 OCSP	Homo sapiens (Human)	355	FUNCTION: Regulates maturation of the transmembrane metalloprotease ADAM10. {ECO:0000250|UniProtKB:Q8VCF5}.		establishment of protein localization to organelle [GO:0072594]	membrane [GO:0016020]	enzyme binding [GO:0019899]	membrane [GO:0016020]; enzyme binding [GO:0019899]; establishment of protein localization to organelle [GO:0072594]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9H205	reviewed	O2AG1_HUMAN	Olfactory receptor 2AG1 (HT3) (Olfactory receptor 2AG3) (Olfactory receptor OR11-79)	OR2AG1 OR2AG3	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H207	reviewed	O10A5_HUMAN	Olfactory receptor 10A5 (HP3) (Olfactory receptor 10A1) (Olfactory receptor 11-403) (OR11-403) (Olfactory receptor-like protein JCG6)	OR10A5 OR10A1	Homo sapiens (Human)	317	FUNCTION: Odorant receptor (Potential). May be involved in taste perception. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H208	reviewed	O10A2_HUMAN	Olfactory receptor 10A2 (HP4) (Olfactory receptor OR11-86)	OR10A2 OR10A2P	Homo sapiens (Human)	303	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H209	reviewed	O10A4_HUMAN	Olfactory receptor 10A4 (HP2) (Olfactory receptor-like protein JCG5)	OR10A4 OR10A4P	Homo sapiens (Human)	315	FUNCTION: Odorant receptor (Potential). May be involved in taste perception. {ECO:0000305}.		axon guidance [GO:0007411]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; axon guidance [GO:0007411]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H210	reviewed	OR2D2_HUMAN	Olfactory receptor 2D2 (HB2) (Olfactory receptor 11-610) (OR11-610) (Olfactory receptor 2D1) (Olfactory receptor OR11-88)	OR2D2 OR2D1	Homo sapiens (Human)	308	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H213	reviewed	MAGH1_HUMAN	Melanoma-associated antigen H1 (Apoptosis-related protein 1) (APR-1) (MAGE-H1 antigen) (Restin)	MAGEH1 APR1	Homo sapiens (Human)	219			apoptotic process [GO:0006915]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; apoptotic process [GO:0006915]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
Q9H2A3	reviewed	NGN2_HUMAN	Neurogenin-2 (NGN-2) (Class A basic helix-loop-helix protein 8) (bHLHa8) (Protein atonal homolog 4)	NEUROG2 ATOH4 BHLHA8 NGN2	Homo sapiens (Human)	272	FUNCTION: Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').		axon development [GO:0061564]; forebrain development [GO:0030900]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]; axon development [GO:0061564]; forebrain development [GO:0030900]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q9H2T7	reviewed	RBP17_HUMAN	Ran-binding protein 17	RANBP17	Homo sapiens (Human)	1088	FUNCTION: May function as a nuclear transport receptor. {ECO:0000250}.		mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]	GTP binding [GO:0005525]; nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; GTP binding [GO:0005525]; nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267]; mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}.
Q9H2W6	reviewed	RM46_HUMAN	Large ribosomal subunit protein mL46 (39S ribosomal protein L46, mitochondrial) (L46mt) (MRP-L46) (P2ECSL)	MRPL46 C15orf4 LIECG2	Homo sapiens (Human)	279			mitochondrial translation [GO:0032543]	cell junction [GO:0030054]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	structural constituent of ribosome [GO:0003735]	cell junction [GO:0030054]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9H2X8	reviewed	I27L2_HUMAN	Interferon alpha-inducible protein 27-like protein 2 (Interferon-stimulated gene 12b protein) (ISG12(b)) (ISG12B) (Protein TLH29) (pIFI27-like protein)	IFI27L2 FAM14A TLH29	Homo sapiens (Human)	130	FUNCTION: Plays a role in the apoptotic process and has a pro-apoptotic activity. {ECO:0000269|PubMed:27673746}.		apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]	mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]		mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:27673746}; Multi-pass membrane protein {ECO:0000255}.
Q9H2Y9	reviewed	SO5A1_HUMAN	Solute carrier organic anion transporter family member 5A1 (Organic anion transporter polypeptide-related protein 4) (OATP-RP4) (OATPRP4) (Solute carrier family 21 member 15)	SLCO5A1 OATP5A1 SLC21A15	Homo sapiens (Human)	848			sodium-independent organic anion transport [GO:0043252]	intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	sodium-independent organic anion transmembrane transporter activity [GO:0015347]	intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; sodium-independent organic anion transport [GO:0043252]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H330	reviewed	TM245_HUMAN	Transmembrane protein 245 (Protein CG-2)	TMEM245 C9orf5	Homo sapiens (Human)	879		MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9H336	reviewed	CRLD1_HUMAN	Cysteine-rich secretory protein LCCL domain-containing 1 (CocoaCrisp) (Cysteine-rich secretory protein 10) (CRISP-10) (LCCL domain-containing cysteine-rich secretory protein 1) (Trypsin inhibitor Hl)	CRISPLD1 CRISP10 LCRISP1 UNQ342/PRO541	Homo sapiens (Human)	500			face morphogenesis [GO:0060325]; hematopoietic stem cell homeostasis [GO:0061484]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]		extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; face morphogenesis [GO:0060325]; hematopoietic stem cell homeostasis [GO:0061484]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H339	reviewed	O51B5_HUMAN	Olfactory receptor 51B5 (Odorant receptor HOR5'beta5) (Olfactory receptor OR11-37)	OR51B5	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H340	reviewed	O51B6_HUMAN	Olfactory receptor 51B6 (Odorant receptor HOR5'beta6)	OR51B6	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H341	reviewed	O51M1_HUMAN	Olfactory receptor 51M1 (Odorant receptor HOR5'beta7) (Olfactory receptor OR11-40)	OR51M1	Homo sapiens (Human)	326	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H342	reviewed	O51J1_HUMAN	Olfactory receptor 51J1 (Odorant receptor HOR5'beta8) (Olfactory receptor 51J2)	OR51J1 OR51J1P OR51J2	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H347	reviewed	UBQL3_HUMAN	Ubiquilin-3	UBQLN3	Homo sapiens (Human)	655			cellular response to stress [GO:0033554]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]	polyubiquitin modification-dependent protein binding [GO:0031593]	cytosol [GO:0005829]; polyubiquitin modification-dependent protein binding [GO:0031593]; cellular response to stress [GO:0033554]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q9H3C7	reviewed	GGNB2_HUMAN	Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403)	GGNBP2 LCRG1 LZK1 ZNF403	Homo sapiens (Human)	697	FUNCTION: May be involved in spermatogenesis.	MISCELLANEOUS: Strongly down-regulated in 40% of primary laryngeal carcinoma and in 6 of 10 various cancer cell lines.	cell differentiation [GO:0030154]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033140]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; cell differentiation [GO:0030154]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033140]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}. Note=Associated with vesicular structures. {ECO:0000250}.
Q9H3E2	reviewed	SNX25_HUMAN	Sorting nexin-25	SNX25 MSTP043	Homo sapiens (Human)	840	FUNCTION: May be involved in several stages of intracellular trafficking. {ECO:0000250}.		negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein transport [GO:0015031]; receptor catabolic process [GO:0032801]	endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]	phosphatidylinositol binding [GO:0035091]	endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; phosphatidylinositol binding [GO:0035091]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein transport [GO:0015031]; receptor catabolic process [GO:0032801]	SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:14975938}; Peripheral membrane protein {ECO:0000269|PubMed:14975938}. Note=Detected in endosome-derived secreted vesicles (exosomes) from malignant pleural effusions.
Q9H3G5	reviewed	CPVL_HUMAN	Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP)	CPVL VLP PSEC0124 UNQ197/PRO223	Homo sapiens (Human)	476	FUNCTION: May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.		proteolysis [GO:0006508]	extracellular exosome [GO:0070062]	serine-type carboxypeptidase activity [GO:0004185]	extracellular exosome [GO:0070062]; serine-type carboxypeptidase activity [GO:0004185]; proteolysis [GO:0006508]	
Q9H3M9	reviewed	ATX3L_HUMAN	Ataxin-3-like protein (EC 3.4.19.12) (Machado-Joseph disease protein 1-like)	ATXN3L ATX3L MJDL	Homo sapiens (Human)	355	FUNCTION: Deubiquitinating enzyme that cleaves both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro) (PubMed:21118805). Acts as a deubiquitinating enzyme for the transcription factor KLF5, playing a role in the regulation of KLF5 stability (PubMed:26079537). {ECO:0000269|PubMed:21118805, ECO:0000269|PubMed:26079537}.	MISCELLANEOUS: Identified only in primates. ATXN3L appeared to have arisen relatively recently, just prior to the first major division between hominids and old world monkeys. {ECO:0000305|PubMed:21118805}.	protein deubiquitination [GO:0016579]	cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; protein deubiquitination [GO:0016579]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9H3S5	reviewed	PIGM_HUMAN	GPI mannosyltransferase 1 (EC 2.4.1.-) (GPI mannosyltransferase I) (GPI-MT-I) (Phosphatidylinositol-glycan biosynthesis class M protein) (PIG-M)	PIGM	Homo sapiens (Human)	423	FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. {ECO:0000269|PubMed:11226175}.			endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-mannosyltransferase I complex [GO:1990529]	alpha-1,4-mannosyltransferase activity [GO:0051751]; glycolipid mannosyltransferase activity [GO:0004376]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-mannosyltransferase I complex [GO:1990529]; alpha-1,4-mannosyltransferase activity [GO:0051751]; glycolipid mannosyltransferase activity [GO:0004376]; mannosyltransferase activity [GO:0000030]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11226175}; Multi-pass membrane protein {ECO:0000269|PubMed:11226175}.
Q9H426	reviewed	RIMS4_HUMAN	Regulating synaptic membrane exocytosis protein 4 (RIM4 gamma) (Rab3-interacting molecule 4) (RIM 4)	RIMS4 C20orf190	Homo sapiens (Human)	269	FUNCTION: Regulates synaptic membrane exocytosis. {ECO:0000250}.		calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; positive regulation of synaptic transmission [GO:0050806]; regulation of membrane potential [GO:0042391]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300]	cytoskeleton of presynaptic active zone [GO:0048788]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]	small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]	cytoskeleton of presynaptic active zone [GO:0048788]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; positive regulation of synaptic transmission [GO:0050806]; regulation of membrane potential [GO:0042391]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300]	SUBCELLULAR LOCATION: Synapse {ECO:0000250}.
Q9H446	reviewed	RWDD1_HUMAN	RWD domain-containing protein 1 (DRG family-regulatory protein 2)	RWDD1 DFRP2 CGI-24 PTD013	Homo sapiens (Human)	243	FUNCTION: Protects DRG2 from proteolytic degradation. {ECO:0000250}.		androgen receptor signaling pathway [GO:0030521]; cellular response to oxidative stress [GO:0034599]; cellular response to testosterone stimulus [GO:0071394]; cytoplasmic translation [GO:0002181]	cytoplasm [GO:0005737]; polysome [GO:0005844]		cytoplasm [GO:0005737]; polysome [GO:0005844]; androgen receptor signaling pathway [GO:0030521]; cellular response to oxidative stress [GO:0034599]; cellular response to testosterone stimulus [GO:0071394]; cytoplasmic translation [GO:0002181]	
Q9H4A4	reviewed	AMPB_HUMAN	Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase)	RNPEP APB	Homo sapiens (Human)	650	FUNCTION: Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). {ECO:0000250}.		proteolysis [GO:0006508]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q9H4B8	reviewed	DPEP3_HUMAN	Dipeptidase 3	DPEP3 UNQ834/PRO1772	Homo sapiens (Human)	488	FUNCTION: Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem (PubMed:32325220). The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (PubMed:32325220). A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance (PubMed:32325220). {ECO:0000269|PubMed:32325220}.		proteolysis [GO:0006508]	acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	dipeptidase activity [GO:0016805]	acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; dipeptidase activity [GO:0016805]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9DA79}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9DA79}.
Q9H4G1	reviewed	CST9L_HUMAN	Cystatin-9-like (Testatin)	CST9L CTES7B UNQ1835/PRO3543	Homo sapiens (Human)	147		MISCELLANEOUS: Lacks critical consensus sites important for cysteine protease inhibition. {ECO:0000305}.	antimicrobial humoral response [GO:0019730]	extracellular space [GO:0005615]	cysteine-type endopeptidase inhibitor activity [GO:0004869]	extracellular space [GO:0005615]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; antimicrobial humoral response [GO:0019730]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H4I8	reviewed	SEHL2_HUMAN	Serine hydrolase-like protein 2 (EC 3.1.-.-)	SERHL2 SERHL	Homo sapiens (Human)	314	FUNCTION: Probable serine hydrolase. May be related to cell muscle hypertrophy.	MISCELLANEOUS: This gene may have been partially duplicated (see SERHL).		perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]	hydrolase activity [GO:0016787]	perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; hydrolase activity [GO:0016787]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}. Peroxisome {ECO:0000250}. Note=Concentrated in perinuclear vesicles. May be located in peroxisomes. {ECO:0000250}.
Q9H501	reviewed	ESF1_HUMAN	ESF1 homolog (ABT1-associated protein)	ESF1 ABTAP C20orf6 HDCMC28P	Homo sapiens (Human)	851	FUNCTION: May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}.		rRNA processing [GO:0006364]	extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}.
Q9H511	reviewed	KLH31_HUMAN	Kelch-like protein 31 (BTB and kelch domain-containing protein 6) (Kelch repeat and BTB domain-containing protein 1) (Kelch-like protein KLHL)	KLHL31 BKLHD6 KBTBD1 KLHL	Homo sapiens (Human)	634	FUNCTION: Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). {ECO:0000269|PubMed:18719355}.		negative regulation of JNK cascade [GO:0046329]; negative regulation of protein phosphorylation [GO:0001933]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein phosphorylation [GO:0001933]	
Q9H5L6	reviewed	THAP9_HUMAN	DNA transposase THAP9 (EC 2.7.7.-) (THAP domain-containing protein 9) (hTh9)	THAP9	Homo sapiens (Human)	903	FUNCTION: Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition. {ECO:0000269|PubMed:20010837, ECO:0000269|PubMed:23349291}.	MISCELLANEOUS: Able to mediate mobilization of P-elements when transfected in Drosophila. {ECO:0000305|PubMed:23349291}.	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA transposition [GO:0006313]		DNA binding [GO:0003677]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; transferase activity [GO:0016740]; transposase activity [GO:0004803]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; transferase activity [GO:0016740]; transposase activity [GO:0004803]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA transposition [GO:0006313]	
Q9H609	reviewed	ZN576_HUMAN	Zinc finger protein 576	ZNF576	Homo sapiens (Human)	170	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H665	reviewed	IGFR1_HUMAN	IGF-like family receptor 1 (Transmembrane protein 149) (U2 small nuclear RNA auxiliary factor 1-like 4)	IGFLR1 TMEM149 U2AF1L4	Homo sapiens (Human)	355	FUNCTION: Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2. {ECO:0000269|PubMed:21454693}.			nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21454693}; Single-pass type I membrane protein {ECO:0000269|PubMed:21454693}.
Q9H6A9	reviewed	PCX3_HUMAN	Pecanex-like protein 3 (Pecanex homolog protein 3)	PCNX3 PCNXL3	Homo sapiens (Human)	2034				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9H6D8	reviewed	FNDC4_HUMAN	Fibronectin type III domain-containing protein 4 (Fibronectin type III repeat-containing protein 1)	FNDC4 FRCP1 UNQ6389/PRO21134	Homo sapiens (Human)	234	FUNCTION: Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to down-regulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by down-regulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. {ECO:0000250|UniProtKB:Q3TR08}.		negative regulation of inflammatory response [GO:0050728]; response to transforming growth factor beta [GO:0071559]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]		endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; negative regulation of inflammatory response [GO:0050728]; response to transforming growth factor beta [GO:0071559]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted {ECO:0000250|UniProtKB:Q3TR08}. Note=The N-terminus is probably cleaved to release a secreted extracellular portion of the protein. {ECO:0000250|UniProtKB:Q3TR08}.
Q9H6F2	reviewed	TM38A_HUMAN	Trimeric intracellular cation channel type A (TRIC-A) (TRICA) (Transmembrane protein 38A)	TMEM38A	Homo sapiens (Human)	299	FUNCTION: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. {ECO:0000250|UniProtKB:Q3TMP8}.		cellular response to caffeine [GO:0071313]; endoplasmic reticulum organization [GO:0007029]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]	extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; sarcoplasmic reticulum membrane [GO:0033017]	identical protein binding [GO:0042802]; potassium channel activity [GO:0005267]	extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; sarcoplasmic reticulum membrane [GO:0033017]; identical protein binding [GO:0042802]; potassium channel activity [GO:0005267]; cellular response to caffeine [GO:0071313]; endoplasmic reticulum organization [GO:0007029]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:A5A6S6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A5A6S6}. Nucleus membrane {ECO:0000250|UniProtKB:A5A6S6}.
Q9H6F5	reviewed	CCD86_HUMAN	Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain)	CCDC86 CYCLON	Homo sapiens (Human)	360				chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	RNA binding [GO:0003723]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9H6K4	reviewed	OPA3_HUMAN	Optic atrophy 3 protein	OPA3	Homo sapiens (Human)	179	FUNCTION: May play some role in mitochondrial processes.		regulation of lipid metabolic process [GO:0019216]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; regulation of lipid metabolic process [GO:0019216]; response to stimulus [GO:0050896]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q9H6V9	reviewed	LDAH_HUMAN	Lipid droplet-associated hydrolase (EC 3.1.1.-) (Lipid droplet-associated serine hydrolase) (hLDAH)	LDAH C2orf43	Homo sapiens (Human)	325	FUNCTION: Probable serine lipid hydrolase associated with lipid droplets. Appears to lack cholesterol esterase activity. Appears to lack triglyceride lipase activity. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages. {ECO:0000250|UniProtKB:Q8BVA5}.		lipid catabolic process [GO:0016042]; lipid storage [GO:0019915]	endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]	sterol esterase activity [GO:0004771]	endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; sterol esterase activity [GO:0004771]; lipid catabolic process [GO:0016042]; lipid storage [GO:0019915]	SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:17135363}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8BVA5}. Note=Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction. {ECO:0000250|UniProtKB:Q8BVA5}.
Q9H6X4	reviewed	TM134_HUMAN	Transmembrane protein 134	TMEM134	Homo sapiens (Human)	195				cytosol [GO:0005829]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]		cytosol [GO:0005829]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27899274}.
Q9H6X5	reviewed	CS044_HUMAN	Uncharacterized protein C19orf44	C19orf44	Homo sapiens (Human)	657							
Q9H756	reviewed	LRC19_HUMAN	Leucine-rich repeat-containing protein 19	LRRC19	Homo sapiens (Human)	370	FUNCTION: Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of pro-inflammatory cytokines (PubMed:19679103, PubMed:25026888). In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances. In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (By similarity). {ECO:0000250|UniProtKB:Q8BZT5, ECO:0000269|PubMed:19679103, ECO:0000269|PubMed:25026888}.		host-mediated regulation of intestinal microbiota composition [GO:0048874]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; regulation of cytokine production [GO:0001817]; regulation of inflammatory response [GO:0050727]; toll-like receptor signaling pathway [GO:0002224]; TRAF-mediated signal transduction [GO:0038008]	plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; regulation of cytokine production [GO:0001817]; regulation of inflammatory response [GO:0050727]; toll-like receptor signaling pathway [GO:0002224]; TRAF-mediated signal transduction [GO:0038008]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9H7C9	reviewed	AAMDC_HUMAN	Mth938 domain-containing protein (Adipogenesis associated Mth938 domain-containing protein)	AAMDC C11orf67 PTD015	Homo sapiens (Human)	122	FUNCTION: May play a role in preadipocyte differentiation and adipogenesis. {ECO:0000250}.		positive regulation of fat cell differentiation [GO:0045600]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; positive regulation of fat cell differentiation [GO:0045600]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Diffuse distribution with some highly concentrated spots around the nucleus. {ECO:0000250}.
Q9H7R0	reviewed	ZN442_HUMAN	Zinc finger protein 442	ZNF442	Homo sapiens (Human)	627	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H7T0	reviewed	CTSRB_HUMAN	Cation channel sperm-associated auxiliary subunit beta (CatSper-beta)	CATSPERB C14orf161	Homo sapiens (Human)	1116	FUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. {ECO:0000250|UniProtKB:A2RTF1}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	CatSper complex [GO:0036128]; cilium [GO:0005929]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]		CatSper complex [GO:0036128]; cilium [GO:0005929]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:A2RTF1}; Single-pass membrane protein {ECO:0000250|UniProtKB:A2RTF1}. Note=Predominantly located in the principal piece of the sperm tail. {ECO:0000250|UniProtKB:A2RTF1}.
Q9H7U1	reviewed	CCSE2_HUMAN	Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog)	CCSER2 FAM190B KIAA1128 NPD012	Homo sapiens (Human)	834	FUNCTION: Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}.		microtubule bundle formation [GO:0001578]	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]	microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; microtubule binding [GO:0008017]; microtubule bundle formation [GO:0001578]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q3UHI0}. Note=Associates with microtubules in interphase. Has diffuse expression throughout the cell during mitosis. {ECO:0000250|UniProtKB:Q3UHI0}.
Q9H7X7	reviewed	IFT22_HUMAN	Intraflagellar transport protein 22 homolog (Rab-like protein 5)	IFT22 RABL5	Homo sapiens (Human)	185	FUNCTION: Small GTPase-like component of the intraflagellar transport (IFT) complex B. {ECO:0000250}.		cilium assembly [GO:0060271]; intracellular protein transport [GO:0006886]; intraciliary anterograde transport [GO:0035720]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; endomembrane system [GO:0012505]; intraciliary transport particle B [GO:0030992]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; endomembrane system [GO:0012505]; intraciliary transport particle B [GO:0030992]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cilium assembly [GO:0060271]; intracellular protein transport [GO:0006886]; intraciliary anterograde transport [GO:0035720]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
Q9H898	reviewed	ZMAT4_HUMAN	Zinc finger matrin-type protein 4	ZMAT4	Homo sapiens (Human)	229				nucleus [GO:0005634]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H8H0	reviewed	NOL11_HUMAN	Nucleolar protein 11	NOL11 L14	Homo sapiens (Human)	719	FUNCTION: Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. {ECO:0000269|PubMed:22916032}.	MISCELLANEOUS: Is the likely candidate for being the functional analog of yeast Utp8. {ECO:0000305|PubMed:22916032}.; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	maturation of SSU-rRNA [GO:0030490]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; t-UTP complex [GO:0034455]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; t-UTP complex [GO:0034455]; RNA binding [GO:0003723]; maturation of SSU-rRNA [GO:0030490]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:22916032}.
Q9H8J5	reviewed	MANS1_HUMAN	MANSC domain-containing protein 1 (Loss of heterozygosity 12 chromosomal region 3 protein)	MANSC1 LOH12CR3 UNQ316/PRO361	Homo sapiens (Human)	431				Golgi apparatus [GO:0005794]; membrane [GO:0016020]		Golgi apparatus [GO:0005794]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9H8S5	reviewed	CCNP_HUMAN	Cyclin-P (Cyclin N-terminal domain-containing protein 2)	CCNP CNTD2	Homo sapiens (Human)	307	FUNCTION: Seems to be involved in the regulation of proliferation and migration. {ECO:0000269|PubMed:28860486, ECO:0000269|PubMed:30087414}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	mitotic cell cycle phase transition [GO:0044772]	centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; mitotic cell cycle phase transition [GO:0044772]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28860486, ECO:0000269|PubMed:30087414}.
Q9H8Y1	reviewed	VRTN_HUMAN	Vertnin	VRTN C14orf115	Homo sapiens (Human)	702			regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]	sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; sequence-specific DNA binding [GO:0043565]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q9H920	reviewed	RN121_HUMAN	E3 ubiquitin ligase RNF121 (EC 2.3.2.27) (RING finger protein 121)	RNF121	Homo sapiens (Human)	327	FUNCTION: E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates thereby promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity). May regulate the unfolded protein response to reduce endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q09251}.		protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q09251}; Multi-pass membrane protein {ECO:0000305}.
Q9H967	reviewed	WDR76_HUMAN	WD repeat-containing protein 76	WDR76	Homo sapiens (Human)	626	FUNCTION: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000250}.		DNA damage response [GO:0006974]; regulation of DNA damage checkpoint [GO:2000001]	heterochromatin [GO:0000792]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]	heterochromatin [GO:0000792]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; DNA damage response [GO:0006974]; regulation of DNA damage checkpoint [GO:2000001]	
Q9H9H5	reviewed	MA6D1_HUMAN	MAP6 domain-containing protein 1 (21 kDa STOP-like protein) (SL21)	MAP6D1	Homo sapiens (Human)	199	FUNCTION: May have microtubule-stabilizing activity. {ECO:0000250}.		cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of microtubule cytoskeleton organization [GO:0070507]	cis-Golgi network [GO:0005801]; Golgi-associated vesicle [GO:0005798]; microtubule [GO:0005874]	calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]	cis-Golgi network [GO:0005801]; Golgi-associated vesicle [GO:0005798]; microtubule [GO:0005874]; calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of microtubule cytoskeleton organization [GO:0070507]	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with microtubules. {ECO:0000250}.
Q9H9Y2	reviewed	RPF1_HUMAN	Ribosome production factor 1 (Brix domain-containing protein 5) (Ribosome biogenesis protein RPF1)	RPF1 BXDC5	Homo sapiens (Human)	349	FUNCTION: May be required for ribosome biogenesis. {ECO:0000269|PubMed:11864606}.		maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]	nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]	RNA binding [GO:0003723]; rRNA primary transcript binding [GO:0042134]	nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]; RNA binding [GO:0003723]; rRNA primary transcript binding [GO:0042134]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Q9HA77	reviewed	SYCM_HUMAN	Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)	CARS2 OK/SW-cl.10	Homo sapiens (Human)	564			cysteinyl-tRNA aminoacylation [GO:0006423]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]	ATP binding [GO:0005524]; cysteine-tRNA ligase activity [GO:0004817]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; ATP binding [GO:0005524]; cysteine-tRNA ligase activity [GO:0004817]; metal ion binding [GO:0046872]; cysteinyl-tRNA aminoacylation [GO:0006423]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
Q9HA92	reviewed	RSAD1_HUMAN	Radical S-adenosyl methionine domain-containing protein 1, mitochondrial (Putative heme chaperone)	RSAD1	Homo sapiens (Human)	442	FUNCTION: May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity (Probable). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity). {ECO:0000250|UniProtKB:P32131, ECO:0000305|PubMed:29282292}.	MISCELLANEOUS: Might carry two S-adenosyl-L-methionine binding sites with only one binding to the iron-sulfur cluster. {ECO:0000250|UniProtKB:P32131}.	porphyrin-containing compound biosynthetic process [GO:0006779]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	4 iron, 4 sulfur cluster binding [GO:0051539]; coproporphyrinogen oxidase activity [GO:0004109]; heme binding [GO:0020037]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; 4 iron, 4 sulfur cluster binding [GO:0051539]; coproporphyrinogen oxidase activity [GO:0004109]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; porphyrin-containing compound biosynthetic process [GO:0006779]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q9HAT1	reviewed	LMA1L_HUMAN	Protein ERGIC-53-like (ERGIC53-like protein) (Lectin mannose-binding 1-like) (LMAN1-like protein)	LMAN1L ERGL UNQ2784/PRO7174	Homo sapiens (Human)	526			endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]	collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]	mannose binding [GO:0005537]	collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; mannose binding [GO:0005537]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]	SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9HAY2	reviewed	MAGF1_HUMAN	Melanoma-associated antigen F1 (MAGE-F1) (MAGE-F1 antigen)	MAGEF1	Homo sapiens (Human)	307	FUNCTION: Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed:29225034). {ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:29225034}.		negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; protein ubiquitination [GO:0016567]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; protein ubiquitination [GO:0016567]	
Q9HB09	reviewed	B2L12_HUMAN	Bcl-2-like protein 12 (Bcl2-L-12) (Bcl-2-related proline-rich protein)	BCL2L12 BPR	Homo sapiens (Human)	334		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	apoptotic process [GO:0006915]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]	membrane [GO:0016020]; nucleus [GO:0005634]		membrane [GO:0016020]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]	
Q9HB40	reviewed	RISC_HUMAN	Retinoid-inducible serine carboxypeptidase (EC 3.4.16.-) (Serine carboxypeptidase 1)	SCPEP1 RISC SCP1 MSTP034 UNQ265/PRO302	Homo sapiens (Human)	452	FUNCTION: May be involved in vascular wall and kidney homeostasis. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	blood vessel diameter maintenance [GO:0097746]; negative regulation of blood pressure [GO:0045776]; proteolysis [GO:0006508]; retinoic acid metabolic process [GO:0042573]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	serine-type carboxypeptidase activity [GO:0004185]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; serine-type carboxypeptidase activity [GO:0004185]; blood vessel diameter maintenance [GO:0097746]; negative regulation of blood pressure [GO:0045776]; proteolysis [GO:0006508]; retinoic acid metabolic process [GO:0042573]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9HBA9	reviewed	FOH1B_HUMAN	Putative N-acetylated-alpha-linked acidic dipeptidase (NAALADase) (EC 3.4.-.-) (Cell growth-inhibiting gene 26 protein) (Prostate-specific membrane antigen-like protein) (Putative folate hydrolase 1B)	FOLH1B PSMAL GIG26	Homo sapiens (Human)	442	FUNCTION: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. {ECO:0000250}.; FUNCTION: Exhibits a dipeptidyl-peptidase IV type activity. {ECO:0000250}.		C-terminal protein deglutamylation [GO:0035609]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallocarboxypeptidase activity [GO:0004181]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallocarboxypeptidase activity [GO:0004181]; C-terminal protein deglutamylation [GO:0035609]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:14716746}.
Q9HBF5	reviewed	ST20_HUMAN	Suppressor of tumorigenicity 20 protein (Human cervical cancer suppressor gene 1 protein) (HCCS-1)	ST20 HCCS1	Homo sapiens (Human)	79	FUNCTION: May act as a tumor suppressor. Promotes apoptosis of cancer cells. {ECO:0000269|PubMed:11857354}.		activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; cellular response to UV-C [GO:0071494]; negative regulation of cell growth [GO:0030308]; positive regulation of apoptotic DNA fragmentation [GO:1902512]		cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]	cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; cellular response to UV-C [GO:0071494]; negative regulation of cell growth [GO:0030308]; positive regulation of apoptotic DNA fragmentation [GO:1902512]	
Q9HBJ7	reviewed	UBP29_HUMAN	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.4.19.12) (Deubiquitinating enzyme 29) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29)	USP29	Homo sapiens (Human)	922	FUNCTION: Deubiquitinase involved in innate antiviral immunity by mediating 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization. {ECO:0000269|PubMed:32457395}.		defense response to virus [GO:0051607]; G1/S transition of mitotic cell cycle [GO:0000082]; innate immune response [GO:0045087]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K48-linked deubiquitination [GO:0071108]; protein stabilization [GO:0050821]	cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]	cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; defense response to virus [GO:0051607]; G1/S transition of mitotic cell cycle [GO:0000082]; innate immune response [GO:0045087]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K48-linked deubiquitination [GO:0071108]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9ES63}. Note=Localizes to perinuclear region in response to herpes simplex virus-1 (HSV-1) infection. {ECO:0000250|UniProtKB:Q9ES63}.
Q9HBL6	reviewed	LRTM1_HUMAN	Leucine-rich repeat and transmembrane domain-containing protein 1	LRTM1 HT017	Homo sapiens (Human)	345			axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]	membrane [GO:0016020]	heparin binding [GO:0008201]; Roundabout binding [GO:0048495]	membrane [GO:0016020]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9HBQ8	reviewed	GGA2B_HUMAN	Putative golgin subfamily A member 2B (Golgin subfamily A member 2-like protein 1)	GOLGA2P5 GOLGA2B GOLGA2L1 PP1757	Homo sapiens (Human)	144							
Q9HBU9	reviewed	POPD2_HUMAN	Popeye domain-containing protein 2 (Popeye protein 2)	POPDC2 POP2	Homo sapiens (Human)	364	FUNCTION: Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. {ECO:0000250|UniProtKB:Q6JWV8, ECO:0000250|UniProtKB:Q9ES82}.		heart development [GO:0007507]; regulation of heart rate [GO:0002027]; regulation of membrane potential [GO:0042391]; skeletal muscle tissue development [GO:0007519]; striated muscle cell differentiation [GO:0051146]	membrane [GO:0016020]; sarcolemma [GO:0042383]	cAMP binding [GO:0030552]	membrane [GO:0016020]; sarcolemma [GO:0042383]; cAMP binding [GO:0030552]; heart development [GO:0007507]; regulation of heart rate [GO:0002027]; regulation of membrane potential [GO:0042391]; skeletal muscle tissue development [GO:0007519]; striated muscle cell differentiation [GO:0051146]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:26642364}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000269|PubMed:26642364}.
Q9HBV1	reviewed	POPD3_HUMAN	Popeye domain-containing protein 3 (Popeye protein 3)	POPDC3 POP3	Homo sapiens (Human)	291	FUNCTION: May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding. May play a role in the regulation of KCNK2/TREK-1-mediated current amplitude (PubMed:31610034). {ECO:0000250|UniProtKB:Q9ES81, ECO:0000269|PubMed:10882522, ECO:0000269|PubMed:31610034}.		heart development [GO:0007507]; regulation of membrane potential [GO:0042391]; skeletal muscle tissue development [GO:0007519]; striated muscle cell differentiation [GO:0051146]	membrane [GO:0016020]; sarcolemma [GO:0042383]	cAMP binding [GO:0030552]	membrane [GO:0016020]; sarcolemma [GO:0042383]; cAMP binding [GO:0030552]; heart development [GO:0007507]; regulation of membrane potential [GO:0042391]; skeletal muscle tissue development [GO:0007519]; striated muscle cell differentiation [GO:0051146]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9HC38	reviewed	GLOD4_HUMAN	Glyoxalase domain-containing protein 4	GLOD4 C17orf25 CGI-150 My027	Homo sapiens (Human)	313		MISCELLANEOUS: Expression is decreased in hepatocellular carcinoma samples as compared to adjacent non-cancerous liver tissues from the same patients. Transfection in hepatocellular carcinoma cells and overexpression can inhibit the cell growth.		extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	cadherin binding [GO:0045296]	extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; cadherin binding [GO:0045296]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:12897971}.
Q9HC56	reviewed	PCDH9_HUMAN	Protocadherin-9	PCDH9	Homo sapiens (Human)	1237	FUNCTION: Potential calcium-dependent cell-adhesion protein.		cell adhesion [GO:0007155]; forebrain development [GO:0030900]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	cell-cell contact zone [GO:0044291]; growth cone [GO:0030426]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	cell-cell contact zone [GO:0044291]; growth cone [GO:0030426]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; forebrain development [GO:0030900]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9HCC6	reviewed	HES4_HUMAN	Transcription factor HES-4 (hHES4) (Class B basic helix-loop-helix protein 42) (bHLHb42) (Hairy and enhancer of split 4) (bHLH factor Hes4)	HES4 BHLHB42	Homo sapiens (Human)	221	FUNCTION: Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity). {ECO:0000250}.		anterior/posterior pattern specification [GO:0009952]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anterior/posterior pattern specification [GO:0009952]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Q9HCG1	reviewed	ZN160_HUMAN	Zinc finger protein 160 (Zinc finger protein HZF5) (Zinc finger protein Kr18) (HKr18)	ZNF160 KIAA1611	Homo sapiens (Human)	818	FUNCTION: May be involved in transcriptional regulation.		hemopoiesis [GO:0030097]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; hemopoiesis [GO:0030097]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9HCI6	reviewed	K1586_HUMAN	E3 SUMO-protein ligase KIAA1586 (EC 2.3.2.-) (E3 SUMO-protein transferase KIAA1586)	KIAA1586	Homo sapiens (Human)	787	FUNCTION: E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493).		protein sumoylation [GO:0016925]		SUMO ligase activity [GO:0061665]	SUMO ligase activity [GO:0061665]; protein sumoylation [GO:0016925]	
Q9HCL0	reviewed	PCD18_HUMAN	Protocadherin-18	PCDH18 KIAA1562	Homo sapiens (Human)	1135	FUNCTION: Potential calcium-dependent cell-adhesion protein.		brain development [GO:0007420]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; brain development [GO:0007420]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9HCN2	reviewed	TPIP1_HUMAN	p53-regulated apoptosis-inducing protein 1 (p53AIP1)	TP53AIP1	Homo sapiens (Human)	124	FUNCTION: May play an important role in mediating p53/TP53-dependent apoptosis. {ECO:0000269|PubMed:11030628}.	MISCELLANEOUS: [Isoform 3]: Dubious isoform. Could be a cloning artifact. {ECO:0000305}.	apoptotic process [GO:0006915]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]		mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; apoptotic process [GO:0006915]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11030628}.
Q9HCN8	reviewed	SDF2L_HUMAN	Stromal cell-derived factor 2-like protein 1 (SDF2-like protein 1) (PWP1-interacting protein 8)	SDF2L1 UNQ1941/PRO4424	Homo sapiens (Human)	221			chaperone cofactor-dependent protein refolding [GO:0051085]; ER-associated misfolded protein catabolic process [GO:0071712]; regulation of apoptotic process [GO:0042981]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]; protein folding chaperone complex [GO:0101031]	ATPase binding [GO:0051117]; misfolded protein binding [GO:0051787]; protein-folding chaperone binding [GO:0051087]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]; protein folding chaperone complex [GO:0101031]; ATPase binding [GO:0051117]; misfolded protein binding [GO:0051787]; protein-folding chaperone binding [GO:0051087]; chaperone cofactor-dependent protein refolding [GO:0051085]; ER-associated misfolded protein catabolic process [GO:0071712]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Q9HCT0	reviewed	FGF22_HUMAN	Fibroblast growth factor 22 (FGF-22)	FGF22 UNQ2500/PRO5800	Homo sapiens (Human)	170	FUNCTION: Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. {ECO:0000269|PubMed:16597617}.		animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; fibroblast growth factor receptor signaling pathway [GO:0008543]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]	fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; fibroblast growth factor receptor signaling pathway [GO:0008543]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9HD33	reviewed	RM47_HUMAN	Large ribosomal subunit protein uL29m (39S ribosomal protein L47, mitochondrial) (L47mt) (MRP-L47) (Nasopharyngeal carcinoma metastasis-related protein 1)	MRPL47 NCM1 CGI-204	Homo sapiens (Human)	250			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9HD64	reviewed	XAGE1_HUMAN	X antigen family member 1 (XAGE-1) (Cancer/testis antigen 12.1) (CT12.1) (G antigen family D member 2)	XAGE1A GAGED2 XAGE1; XAGE1B XAGE1C XAGE1D XAGE1E	Homo sapiens (Human)	81		MISCELLANEOUS: According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified.; MISCELLANEOUS: [Isoform B]: XAGE-1a and XAGE-1b mRNAs are produced by alternative promoter usage. However, for both isoforms, the translation initiator codon remains the same, generating an identical protein. XAGE-1b is the predominant transcript, compared to XAGE-1a.					
Q9HDB9	reviewed	GAK5_HUMAN	Endogenous retrovirus group K member 5 Gag polyprotein (HERV-K(II) Gag protein) (HERV-K_3q12.3 provirus ancestral Gag polyprotein) (Gag polyprotein)	ERVK-5 ERVK5	Homo sapiens (Human)	667	FUNCTION: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: Intergenic, closest flanking genes being RPL24 and FLJ23047.	viral process [GO:0016032]	plasma membrane [GO:0005886]	nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]; nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.
Q9N2J8	reviewed	ENH3_HUMAN	HERV-H_2q24.1 provirus ancestral Env polyprotein (Env protein HERV-H/p59) (Envelope polyprotein) (HERV-H/env59) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]		Homo sapiens (Human)	555	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: Orthologs in P.troglodytes, G.gorilla (truncated) and P.pygmaeus (truncated).; MISCELLANEOUS: HERV-H family subgenomic RNAs have been observed.; MISCELLANEOUS: This provirus is intergenic, the closest flanking genes being KCNJ3 and NR4A2.		plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Virion.; SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NNX1	reviewed	TUFT1_HUMAN	Tuftelin	TUFT1	Homo sapiens (Human)	390	FUNCTION: Involved in the mineralization and structural organization of enamel. {ECO:0000250|UniProtKB:P27628}.		bone mineralization [GO:0030282]; intracellular signal transduction [GO:0035556]; odontogenesis [GO:0042476]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	structural constituent of tooth enamel [GO:0030345]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; structural constituent of tooth enamel [GO:0030345]; bone mineralization [GO:0030282]; intracellular signal transduction [GO:0035556]; odontogenesis [GO:0042476]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P27628}. Note=Secreted at a very early stage of enamel formation, concentrated at the dentin-enamel junction and tightly bound to the surface of the growing crystallites. {ECO:0000250|UniProtKB:P27628}.
Q9NP08	reviewed	HMX1_HUMAN	Homeobox protein HMX1 (Homeobox protein H6)	HMX1 H6	Homo sapiens (Human)	348	FUNCTION: DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear. {ECO:0000269|PubMed:10206974}.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NP92	reviewed	RT30_HUMAN	Large ribosomal subunit protein mL65 (39S ribosomal protein S30, mitochondrial) (MRP-S30) (S30mt) (Large ribosomal subunit protein mS30) (Programmed cell death protein 9)	MRPS30 PDCD9 BM-047	Homo sapiens (Human)	439			apoptotic process [GO:0006915]; mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; apoptotic process [GO:0006915]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279123, ECO:0000269|PubMed:28892042}.
Q9NPA3	reviewed	M1IP1_HUMAN	Mid1-interacting protein 1 (Gastrulation-specific G12-like protein) (Mid1-interacting G12-like protein) (Protein STRAIT11499) (Spot 14-related protein) (S14R) (Spot 14-R)	MID1IP1 MIG12	Homo sapiens (Human)	183	FUNCTION: Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity). {ECO:0000250}.		lipid metabolic process [GO:0006629]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of ligase activity [GO:0051351]; protein polymerization [GO:0051258]; regulation of lipid biosynthetic process [GO:0046890]	cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; lipid metabolic process [GO:0006629]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of ligase activity [GO:0051351]; protein polymerization [GO:0051258]; regulation of lipid biosynthetic process [GO:0046890]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9CQ20}. Cytoplasm {ECO:0000250|UniProtKB:Q9CQ20}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9CQ20}. Note=Associated with microtubules. {ECO:0000250|UniProtKB:Q9CQ20}.
Q9NPB8	reviewed	GPCP1_HUMAN	Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5)	GPCPD1 GDE5 KIAA1434	Homo sapiens (Human)	672	FUNCTION: May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity. {ECO:0000250}.		glycerophospholipid catabolic process [GO:0046475]; skeletal muscle tissue development [GO:0007519]	cytosol [GO:0005829]	glycerophosphocholine phosphodiesterase activity [GO:0047389]; starch binding [GO:2001070]	cytosol [GO:0005829]; glycerophosphocholine phosphodiesterase activity [GO:0047389]; starch binding [GO:2001070]; glycerophospholipid catabolic process [GO:0046475]; skeletal muscle tissue development [GO:0007519]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
Q9NPH6	reviewed	OBP2B_HUMAN	Odorant-binding protein 2b (Odorant-binding protein IIb) (OBPIIb)	OBP2B UNQ653/PRO1283	Homo sapiens (Human)	170	FUNCTION: Probably binds and transports small hydrophobic volatile molecules.		chemosensory behavior [GO:0007635]; sensory perception of smell [GO:0007608]	extracellular space [GO:0005615]	odorant binding [GO:0005549]; small molecule binding [GO:0036094]	extracellular space [GO:0005615]; odorant binding [GO:0005549]; small molecule binding [GO:0036094]; chemosensory behavior [GO:0007635]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9NQ03	reviewed	SCRT2_HUMAN	Transcriptional repressor scratch 2 (Scratch homolog 2 zinc finger protein)	SCRT2 FP7030	Homo sapiens (Human)	307	FUNCTION: May be involved in transcriptional regulation.		negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron migration [GO:2001222]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron migration [GO:2001222]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NQ34	reviewed	TMM9B_HUMAN	Transmembrane protein 9B	TMEM9B C11orf15 UNQ712/PRO1375	Homo sapiens (Human)	198	FUNCTION: Enhances production of pro-inflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways. {ECO:0000269|PubMed:18541524}.		positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]		early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:18541524}; Single-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:18541524}; Single-pass membrane protein {ECO:0000255}.
Q9NQ60	reviewed	EQTN_HUMAN	Equatorin (Acrosome formation-associated factor)	EQTN AFAF C9orf11	Homo sapiens (Human)	294	FUNCTION: Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. {ECO:0000250}.		acrosomal vesicle exocytosis [GO:0060478]; endocytosis [GO:0006897]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	inner acrosomal membrane [GO:0002079]; outer acrosomal membrane [GO:0002081]; plasma membrane [GO:0005886]		inner acrosomal membrane [GO:0002079]; outer acrosomal membrane [GO:0002081]; plasma membrane [GO:0005886]; acrosomal vesicle exocytosis [GO:0060478]; endocytosis [GO:0006897]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=In the anterior acrosome region, enriched on the inner acrosomal membrane but minimal on the outer acrosomal membrane; in contrast in the posterior acrosome region enriched on both the inner and outer acrosomal membranes. {ECO:0000250}.
Q9NQA3	reviewed	WASH6_HUMAN	WAS protein family homolog 6 (Protein FAM39A)	WASH6P CXYorf1 FAM39A	Homo sapiens (Human)	447	FUNCTION: May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}.	MISCELLANEOUS: WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes. {ECO:0000305|PubMed:18159949}.	Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:A8K0Z3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8VDD8}. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2. {ECO:0000250|UniProtKB:A8K0Z3}.
Q9NQE7	reviewed	TSSP_HUMAN	Thymus-specific serine protease (EC 3.4.-.-) (Serine protease 16)	PRSS16 TSSP	Homo sapiens (Human)	514	FUNCTION: Protease that may play a role in T-cell development.		protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	endosome [GO:0005768]; lysosome [GO:0005764]	dipeptidyl-peptidase activity [GO:0008239]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236]	endosome [GO:0005768]; lysosome [GO:0005764]; dipeptidyl-peptidase activity [GO:0008239]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal.
Q9NQN1	reviewed	OR2S1_HUMAN	Olfactory receptor 2S2 (Olfactory receptor OR9-3)	OR2S2	Homo sapiens (Human)	319	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9NQS1	reviewed	AVEN_HUMAN	Cell death regulator Aven	AVEN	Homo sapiens (Human)	362	FUNCTION: Protects against apoptosis mediated by Apaf-1.		apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]		cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]	SUBCELLULAR LOCATION: Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes.
Q9NQT6	reviewed	FSCN3_HUMAN	Fascin-3 (Testis fascin)	FSCN3	Homo sapiens (Human)	498	FUNCTION: Acts as an actin bundling protein. {ECO:0000250}.		actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]	actin cytoskeleton [GO:0015629]; cell projection membrane [GO:0031253]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; ruffle [GO:0001726]	actin filament binding [GO:0051015]; protein-macromolecule adaptor activity [GO:0030674]	actin cytoskeleton [GO:0015629]; cell projection membrane [GO:0031253]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; ruffle [GO:0001726]; actin filament binding [GO:0051015]; protein-macromolecule adaptor activity [GO:0030674]; actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q9NQZ5	reviewed	STAR7_HUMAN	StAR-related lipid transfer protein 7, mitochondrial (Gestational trophoblastic tumor protein 1) (START domain-containing protein 7) (StARD7)	STARD7 GTT1	Homo sapiens (Human)	370	FUNCTION: May play a protective role in mucosal tissues by preventing exaggerated allergic responses. {ECO:0000250|UniProtKB:Q8R1R3}.			mitochondrial outer membrane [GO:0005741]	lipid binding [GO:0008289]	mitochondrial outer membrane [GO:0005741]; lipid binding [GO:0008289]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q9NR64	reviewed	KLHL1_HUMAN	Kelch-like protein 1	KLHL1 KIAA1490	Homo sapiens (Human)	748	FUNCTION: May play a role in organizing the actin cytoskeleton of the brain cells.		actin cytoskeleton organization [GO:0030036]; adult walking behavior [GO:0007628]; cerebellar Purkinje cell layer development [GO:0021680]; dendrite development [GO:0016358]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]	actin binding [GO:0003779]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; actin binding [GO:0003779]; actin cytoskeleton organization [GO:0030036]; adult walking behavior [GO:0007628]; cerebellar Purkinje cell layer development [GO:0021680]; dendrite development [GO:0016358]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
Q9NR77	reviewed	PXMP2_HUMAN	Peroxisomal membrane protein 2 (22 kDa peroxisomal membrane protein)	PXMP2 PMP22	Homo sapiens (Human)	195	FUNCTION: Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.			cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; protein-containing complex [GO:0032991]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; protein-containing complex [GO:0032991]	SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein.
Q9NRG7	reviewed	D39U1_HUMAN	Epimerase family protein SDR39U1 (EC 1.1.1.-) (Short-chain dehydrogenase/reductase family 39U member 1)	SDR39U1 C14orf124 HCDI	Homo sapiens (Human)	293	FUNCTION: Putative NADP-dependent oxidoreductase. {ECO:0000305}.	MISCELLANEOUS: Despite its name, it shares more sequence similarity with the sugar epimerase family than with the short-chain dehydrogenases/reductases (SDR) family.		nucleus [GO:0005634]	oxidoreductase activity [GO:0016491]	nucleus [GO:0005634]; oxidoreductase activity [GO:0016491]	
Q9NRH1	reviewed	YAE1_HUMAN	Protein YAE1 homolog (Yae1 domain-containing protein 1)	YAE1 C7orf36 YAE1D1 GK003	Homo sapiens (Human)	226	FUNCTION: The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:26182403). {ECO:0000269|PubMed:26182403}.		protein maturation by [4Fe-4S] cluster transfer [GO:0106035]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47118}. Nucleus {ECO:0000250|UniProtKB:P47118}.
Q9NRJ1	reviewed	MOST1_HUMAN	Protein MOST-1	C8orf17	Homo sapiens (Human)	99	FUNCTION: May be involved in cell survival, proliferation and progression of cancer cells. {ECO:0000269|PubMed:12665628}.		negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17143515}. Microsome membrane {ECO:0000269|PubMed:17143515}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17143515}.
Q9NRJ5	reviewed	PAPOB_HUMAN	Poly(A) polymerase beta (PAP-beta) (EC 2.7.7.19) (Polynucleotide adenylyltransferase beta) (Testis-specific poly(A) polymerase)	PAPOLB PAPT	Homo sapiens (Human)	637			mRNA polyadenylation [GO:0006378]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; mRNA polyadenylation [GO:0006378]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NRM2	reviewed	ZN277_HUMAN	Zinc finger protein 277 (Nuclear receptor-interacting factor 4)	ZNF277 NRIF4 ZNF277P	Homo sapiens (Human)	450	FUNCTION: Probable transcription factor. Involved in modulation of cellular senescence; represses transcription of the tumor suppressor gene INK4A/ARF, perhaps acting via the Polycomb group (PcG) complex PRC1. {ECO:0000250|UniProtKB:E9Q6D6}.		cellular response to hydrogen peroxide [GO:0070301]; regulation of cellular senescence [GO:2000772]	nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cellular response to hydrogen peroxide [GO:0070301]; regulation of cellular senescence [GO:2000772]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NRN5	reviewed	OLFL3_HUMAN	Olfactomedin-like protein 3 (HNOEL-iso) (hOLF44)	OLFML3 PSEC0035 PSEC0173 PSEC0244 UNQ663/PRO1294	Homo sapiens (Human)	406	FUNCTION: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes. {ECO:0000250, ECO:0000269|PubMed:15280020}.		signal transduction [GO:0007165]	extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]		extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15280020}.
Q9NRR1	reviewed	CYTL1_HUMAN	Cytokine-like protein 1 (Protein C17)	CYTL1 C4orf4 UNQ1942/PRO4425	Homo sapiens (Human)	136			cartilage homeostasis [GO:1990079]; chondrocyte differentiation [GO:0002062]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; inner ear development [GO:0048839]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]	extracellular space [GO:0005615]	signaling receptor binding [GO:0005102]	extracellular space [GO:0005615]; signaling receptor binding [GO:0005102]; cartilage homeostasis [GO:1990079]; chondrocyte differentiation [GO:0002062]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; inner ear development [GO:0048839]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10857752}.
Q9NRU3	reviewed	CNNM1_HUMAN	Metal transporter CNNM1 (Ancient conserved domain-containing protein 1) (Cyclin-M1)	CNNM1 ACDP1	Homo sapiens (Human)	951	FUNCTION: Probable metal transporter. {ECO:0000250}.	MISCELLANEOUS: Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.	magnesium ion homeostasis [GO:0010960]; monoatomic ion transport [GO:0006811]	plasma membrane [GO:0005886]	transmembrane transporter activity [GO:0022857]	plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; magnesium ion homeostasis [GO:0010960]; monoatomic ion transport [GO:0006811]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9NRV9	reviewed	HEBP1_HUMAN	Heme-binding protein 1 (p22HBP)	HEBP1 HBP	Homo sapiens (Human)	189	FUNCTION: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities. {ECO:0000269|PubMed:12413491}.		circadian rhythm [GO:0007623]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	heme binding [GO:0020037]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; heme binding [GO:0020037]; circadian rhythm [GO:0007623]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12413491}.
Q9NRX2	reviewed	RM17_HUMAN	Large ribosomal subunit protein bL17m (39S ribosomal protein L17, mitochondrial) (L17mt) (MRP-L17) (LYST-interacting protein 2)	MRPL17 LIP2	Homo sapiens (Human)	175			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	protein domain specific binding [GO:0019904]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; protein domain specific binding [GO:0019904]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9NRY5	reviewed	F1142_HUMAN	Protein FAM114A2	FAM114A2 C5orf3	Homo sapiens (Human)	505					purine nucleotide binding [GO:0017076]	purine nucleotide binding [GO:0017076]	
Q9NS25	reviewed	SPNXB_HUMAN	Sperm protein associated with the nucleus on the X chromosome B1 (Cancer/testis antigen 11.2) (CT11.2) (Nuclear-associated protein SPAN-Xb) (SPANX-B) (SPANX family member B1) (SPANX family member F1)	SPANXB1 SPANXB SPANXB2 SPANXF1	Homo sapiens (Human)	103			spermatid development [GO:0007286]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10906052}. Nucleus {ECO:0000269|PubMed:10906052}. Note=Associated with nuclear craters.
Q9NS26	reviewed	SPNXA_HUMAN	Sperm protein associated with the nucleus on the X chromosome A (Cancer/testis antigen 11.1) (CT11.1) (Nuclear-associated protein SPAN-Xa) (SPAN-X) (SPANX-A) (SPANX family member A)	SPANXA1 SPANXA; SPANXA2	Homo sapiens (Human)	97			spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10906052}. Nucleus {ECO:0000269|PubMed:10906052}. Note=Associated with nuclear craters.
Q9NS28	reviewed	RGS18_HUMAN	Regulator of G-protein signaling 18 (RGS18)	RGS18 RGS13	Homo sapiens (Human)	235	FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha. {ECO:0000269|PubMed:11042171, ECO:0000269|PubMed:11955952}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9NS66	reviewed	GP173_HUMAN	Probable G-protein coupled receptor 173 (Super conserved receptor expressed in brain 3)	GPR173 SREB3	Homo sapiens (Human)	373	FUNCTION: Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (By similarity). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (By similarity). In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (PubMed:30933929). {ECO:0000250|UniProtKB:Q9JJH2, ECO:0000269|PubMed:30933929}.		negative regulation of neuron migration [GO:2001223]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; gonadotropin-releasing hormone receptor activity [GO:0004968]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; gonadotropin-releasing hormone receptor activity [GO:0004968]; negative regulation of neuron migration [GO:2001223]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q9NS93	reviewed	TM7S3_HUMAN	Transmembrane 7 superfamily member 3 (Seven span transmembrane protein)	TM7SF3	Homo sapiens (Human)	570	FUNCTION: Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623). {ECO:0000269|PubMed:21853325, ECO:0000269|PubMed:27740623}.		cellular response to unfolded protein [GO:0034620]; negative regulation of programmed cell death [GO:0043069]; positive regulation of insulin secretion [GO:0032024]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]		extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; cellular response to unfolded protein [GO:0034620]; negative regulation of programmed cell death [GO:0043069]; positive regulation of insulin secretion [GO:0032024]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10828615}; Multi-pass membrane protein {ECO:0000255}.
Q9NS98	reviewed	SEM3G_HUMAN	Semaphorin-3G (Semaphorin sem2)	SEMA3G	Homo sapiens (Human)	782	FUNCTION: Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity). {ECO:0000250}.		axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	extracellular exosome [GO:0070062]	chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; signaling receptor binding [GO:0005102]	extracellular exosome [GO:0070062]; chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215]; signaling receptor binding [GO:0005102]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q9NSD7	reviewed	RL3R1_HUMAN	Relaxin-3 receptor 1 (RLN3 receptor 1) (G protein-coupled receptor SALPR) (G-protein coupled receptor GPCR135) (Relaxin family peptide receptor 3) (Somatostatin- and angiotensin-like peptide receptor)	RXFP3 GPCR135 RLN3R1 SALPR	Homo sapiens (Human)	469	FUNCTION: Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation. {ECO:0000269|PubMed:14522968}.		G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytokinesis [GO:0032467]	plasma membrane [GO:0005886]	G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytokinesis [GO:0032467]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9NSI2	reviewed	SLX9_HUMAN	Ribosome biogenesis protein SLX9 homolog	SLX9 C21orf70 FAM207A PRED56	Homo sapiens (Human)	230	FUNCTION: May be involved in ribosome biogenesis. {ECO:0000250|UniProtKB:P53251}.		maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]; preribosome, small subunit precursor [GO:0030688]		90S preribosome [GO:0030686]; nucleolus [GO:0005730]; preribosome, small subunit precursor [GO:0030688]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P53251}.
Q9NSI5	reviewed	IGSF5_HUMAN	Immunoglobulin superfamily member 5 (IgSF5) (Junctional adhesion molecule 4) (JAM-4)	IGSF5 JAM4	Homo sapiens (Human)	407	FUNCTION: Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity). {ECO:0000250}.	MISCELLANEOUS: A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells. {ECO:0000305|PubMed:22042635}.	cell-cell adhesion [GO:0098609]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]		apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; cell-cell adhesion [GO:0098609]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q5VJ70}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q5VJ70}.
Q9NSY0	reviewed	NRBP2_HUMAN	Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16)	NRBP2 PP9320 TRG16	Homo sapiens (Human)	501	FUNCTION: May regulate apoptosis of neural progenitor cells during their differentiation. {ECO:0000250}.	MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron apoptotic process [GO:0043524]; neuron differentiation [GO:0030182]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron apoptotic process [GO:0043524]; neuron differentiation [GO:0030182]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9NTI7	reviewed	INKA2_HUMAN	PAK4-inhibitor INKA2 (Induced in neural crest by AP2-alpha protein-related homolog) (Inca-r) (Inka-box actin regulator 2)	INKA2 C1orf183 FAM212B	Homo sapiens (Human)	297	FUNCTION: Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity. {ECO:0000250|UniProtKB:Q96EL1}.			intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]	intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26607847}.
Q9NTU4	reviewed	CTSRZ_HUMAN	Cation channel sperm-associated auxiliary subunit zeta (CatSper-zeta) (CatSperzeta) (Testis-expressed protein 40)	CATSPERZ C11orf20 TEX40	Homo sapiens (Human)	200	FUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel. {ECO:0000250|UniProtKB:Q9CQP8}.		flagellated sperm motility [GO:0030317]; male meiotic nuclear division [GO:0007140]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]	CatSper complex [GO:0036128]; cytoplasm [GO:0005737]; sperm principal piece [GO:0097228]		CatSper complex [GO:0036128]; cytoplasm [GO:0005737]; sperm principal piece [GO:0097228]; flagellated sperm motility [GO:0030317]; male meiotic nuclear division [GO:0007140]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:28226241}; Peripheral membrane protein {ECO:0000305}. Note=Specifically located in the principal piece of sperm tail (PubMed:28226241). Although it does not contain a transmembrane domain, localizes with the CatSper complex at the flagellum membrane (PubMed:28226241). {ECO:0000269|PubMed:28226241}.
Q9NTU7	reviewed	CBLN4_HUMAN	Cerebellin-4 (Cerebellin-like glycoprotein 1)	CBLN4 CBLNL1 UNQ718/PRO1382	Homo sapiens (Human)	201	FUNCTION: Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity). Essential for the formation and maintenance of inhibitory GABAergic synapses (By similarity). Promotes the development of dendrite-targeting inhibitory GABAergic synapses made by somatostatin-positive interneurons (By similarity). May contribute to the function of ventral medial habenula region of the brain implicated in the regulation of anxiety-related behaviors (By similarity). May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity). {ECO:0000250|UniProtKB:Q8BME9}.		inhibitory synapse assembly [GO:1904862]; protein secretion [GO:0009306]	collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; synapse [GO:0045202]		collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; synapse [GO:0045202]; inhibitory synapse assembly [GO:1904862]; protein secretion [GO:0009306]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8BME9}. Synapse {ECO:0000250|UniProtKB:Q8BME9}. Note=Detected at GABAergic synapses. {ECO:0000250|UniProtKB:Q8BME9}.
Q9NTX5	reviewed	ECHD1_HUMAN	Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD)	ECHDC1	Homo sapiens (Human)	307	FUNCTION: Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Acts preferentially on (S)-ethylmalonyl-CoA but has also some activity on the (R)-isomer (By similarity). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity). {ECO:0000250|UniProtKB:Q9D9V3, ECO:0000269|PubMed:22016388}.		fatty acid beta-oxidation [GO:0006635]	cytosol [GO:0005829]	carboxy-lyase activity [GO:0016831]; methyl/ethyl malonyl-CoA decarboxylase activity [GO:0004492]	cytosol [GO:0005829]; carboxy-lyase activity [GO:0016831]; methyl/ethyl malonyl-CoA decarboxylase activity [GO:0004492]; fatty acid beta-oxidation [GO:0006635]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:22016388}.
Q9NTZ6	reviewed	RBM12_HUMAN	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN)	RBM12 KIAA0765 HRIHFB2091	Homo sapiens (Human)	932			regulation of RNA splicing [GO:0043484]	nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; RNA binding [GO:0003723]; regulation of RNA splicing [GO:0043484]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9853615}.
Q9NU02	reviewed	ANKE1_HUMAN	Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5)	ANKEF1 ANKRD5	Homo sapiens (Human)	776					calcium ion binding [GO:0005509]	calcium ion binding [GO:0005509]	
Q9NUA8	reviewed	ZBT40_HUMAN	Zinc finger and BTB domain-containing protein 40	ZBTB40 KIAA0478	Homo sapiens (Human)	1239	FUNCTION: May be involved in transcriptional regulation.		bone mineralization [GO:0030282]; DNA damage response [GO:0006974]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; bone mineralization [GO:0030282]; DNA damage response [GO:0006974]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NUG6	reviewed	PDRG1_HUMAN	p53 and DNA damage-regulated protein 1	PDRG1 C20orf126 PDRG	Homo sapiens (Human)	133	FUNCTION: May play a role in chaperone-mediated protein folding. {ECO:0000305}.		protein folding [GO:0006457]; protein stabilization [GO:0050821]	cytoplasm [GO:0005737]; prefoldin complex [GO:0016272]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]	unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; prefoldin complex [GO:0016272]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q9NUP1	reviewed	BL1S4_HUMAN	Biogenesis of lysosome-related organelles complex 1 subunit 4 (BLOC-1 subunit 4) (Protein cappuccino homolog)	BLOC1S4 CNO	Homo sapiens (Human)	217	FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:17182842}.		anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; melanosome organization [GO:0032438]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; platelet aggregation [GO:0070527]	axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737]; cytosol [GO:0005829]		axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; melanosome organization [GO:0032438]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; platelet aggregation [GO:0070527]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9NUP7	reviewed	TRM13_HUMAN	tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76)	TRMT13 CCDC76	Homo sapiens (Human)	481	FUNCTION: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). {ECO:0000250|UniProtKB:Q12383}.		tRNA methylation [GO:0030488]		metal ion binding [GO:0046872]; tRNA 2'-O-methyltransferase activity [GO:0106050]; tRNA methyltransferase activity [GO:0008175]	metal ion binding [GO:0046872]; tRNA 2'-O-methyltransferase activity [GO:0106050]; tRNA methyltransferase activity [GO:0008175]; tRNA methylation [GO:0030488]	
Q9NUQ6	reviewed	SPS2L_HUMAN	SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP)	SPATS2L DNAPTP6 SP1224	Homo sapiens (Human)	558				cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19005571}. Nucleus, nucleolus {ECO:0000269|PubMed:19005571}. Note=During oxidative stress as well as UV irradiation, energy deprivation or heat shock, relocalizes to cytoplasmic stress granules. In the nucleus, found in structures lacking NPM1.
Q9NUQ8	reviewed	ABCF3_HUMAN	ATP-binding cassette sub-family F member 3	ABCF3	Homo sapiens (Human)	709	FUNCTION: Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. {ECO:0000250}.		defense response to virus [GO:0051607]	membrane [GO:0016020]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]	membrane [GO:0016020]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; defense response to virus [GO:0051607]	
Q9NUZ1	reviewed	ACOXL_HUMAN	Acyl-coenzyme A oxidase-like protein (Acyl-CoA oxidase-like protein) (EC 1.3.3.-)	ACOXL	Homo sapiens (Human)	547			fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; lipid homeostasis [GO:0055088]	peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]	peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; lipid homeostasis [GO:0055088]	
Q9NV66	reviewed	TYW1_HUMAN	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA wybutosine-synthesizing protein 1 homolog) (tRNA-yW-synthesizing protein)	TYW1 RSAFD1	Homo sapiens (Human)	732	FUNCTION: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). {ECO:0000250}.		wybutosine biosynthetic process [GO:0031591]		4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; tRNA-4-demethylwyosine synthase activity [GO:0102521]	4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; tRNA-4-demethylwyosine synthase activity [GO:0102521]; wybutosine biosynthetic process [GO:0031591]	
Q9NV72	reviewed	ZN701_HUMAN	Zinc finger protein 701	ZNF701	Homo sapiens (Human)	531	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NVE5	reviewed	UBP40_HUMAN	Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.4.19.12) (Deubiquitinating enzyme 40) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40)	USP40	Homo sapiens (Human)	1235	FUNCTION: May be catalytically inactive.		proteolysis [GO:0006508]	cytosol [GO:0005829]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]	
Q9NVG8	reviewed	TBC13_HUMAN	TBC1 domain family member 13	TBC1D13	Homo sapiens (Human)	400	FUNCTION: Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. {ECO:0000250|UniProtKB:Q8R3D1}.		intracellular protein transport [GO:0006886]	cytosol [GO:0005829]; membrane [GO:0016020]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; membrane [GO:0016020]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8R3D1}. Cytoplasm {ECO:0000250|UniProtKB:Q8R3D1}.
Q9NVK5	reviewed	FGOP2_HUMAN	FGFR1 oncogene partner 2	FGFR1OP2 HSPC123	Homo sapiens (Human)	253	FUNCTION: May be involved in wound healing pathway. {ECO:0000250}.		response to wounding [GO:0009611]; wound healing [GO:0042060]	cytosol [GO:0005829]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; identical protein binding [GO:0042802]; response to wounding [GO:0009611]; wound healing [GO:0042060]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9NVP4	reviewed	DZAN1_HUMAN	Double zinc ribbon and ankyrin repeat-containing protein 1	DZANK1 C20orf12 C20orf84	Homo sapiens (Human)	752	FUNCTION: Involved in vesicle transport in photoreceptor cells. {ECO:0000250|UniProtKB:Q1LXR6}.		eye photoreceptor cell development [GO:0042462]	centrosome [GO:0005813]	metal ion binding [GO:0046872]	centrosome [GO:0005813]; metal ion binding [GO:0046872]; eye photoreceptor cell development [GO:0042462]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26485514}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:26485514}. Note=Colocalizes with NINL at the base of cilia. {ECO:0000269|PubMed:26485514}.
Q9NVQ4	reviewed	FAIM1_HUMAN	Fas apoptotic inhibitory molecule 1	FAIM FAIM1	Homo sapiens (Human)	179	FUNCTION: Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. {ECO:0000250}.		apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of neurogenesis [GO:0050769]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of neurogenesis [GO:0050769]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9NVR2	reviewed	INT10_HUMAN	Integrator complex subunit 10 (Int10)	INTS10 C8orf35	Homo sapiens (Human)	710	FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.		regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180]	integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267}.
Q9NVR7	reviewed	TBCC1_HUMAN	TBCC domain-containing protein 1	TBCCD1	Homo sapiens (Human)	557	FUNCTION: Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration. {ECO:0000269|PubMed:20168327}.		maintenance of centrosome location [GO:0051661]; maintenance of Golgi location [GO:0051684]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]	cytoplasm [GO:0005737]; spindle pole centrosome [GO:0031616]		cytoplasm [GO:0005737]; spindle pole centrosome [GO:0031616]; maintenance of centrosome location [GO:0051661]; maintenance of Golgi location [GO:0051684]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20168327}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20168327}. Note=Localizes at the spindle midzone, midbody and basal bodies of primary and motile cilia.
Q9NVS2	reviewed	RT18A_HUMAN	Large ribosomal subunit protein mL66 (39S ribosomal protein S18-3, mitochondrial) (MRP-S18-3) (39S ribosomal protein S18a, mitochondrial) (MRP-S18-a) (Mrps18a) (S18mt-a) (Large ribosomal subunit protein bS18a)	MRPS18A	Homo sapiens (Human)	196		MISCELLANEOUS: There are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c) binds to the same site as bacterial bS18, mS40 (bS18b) binds to a novel location of the 28S small subunit, and mL66 (bS18a, this protein) binds to the 39S large subunit. {ECO:0000305|PubMed:27023846}.	mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9NVX7	reviewed	KBTB4_HUMAN	Kelch repeat and BTB domain-containing protein 4 (BTB and kelch domain-containing protein 4)	KBTBD4 BKLHD4	Homo sapiens (Human)	518							
Q9NVZ3	reviewed	NECP2_HUMAN	Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2)	NECAP2	Homo sapiens (Human)	263	FUNCTION: Involved in endocytosis. {ECO:0000250}.		endocytosis [GO:0006897]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]		clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; endocytosis [GO:0006897]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with AP-2 at the plasma membrane. {ECO:0000250}.
Q9NW68	reviewed	BSDC1_HUMAN	BSD domain-containing protein 1	BSDC1 UNQ2494/PRO5781	Homo sapiens (Human)	430				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q9NWA0	reviewed	MED9_HUMAN	Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9)	MED9 MED25	Homo sapiens (Human)	146	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.		positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleus [GO:0005634]	transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleus [GO:0005634]; transcription coregulator activity [GO:0003712]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NWB6	reviewed	ARGL1_HUMAN	Arginine and glutamate-rich protein 1	ARGLU1	Homo sapiens (Human)	273	FUNCTION: Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. {ECO:0000269|PubMed:21454576}.			cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	cadherin binding [GO:0045296]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; cadherin binding [GO:0045296]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21454576}. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters. Colocalizes with MED1.
Q9NWC5	reviewed	TM45A_HUMAN	Transmembrane protein 45A (DNA polymerase-transactivated protein 4) (Dermal papilla-derived protein 7)	TMEM45A DERP7 DNAPTP4	Homo sapiens (Human)	275				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NWH7	reviewed	SPAT6_HUMAN	Spermatogenesis-associated protein 6	SPATA6	Homo sapiens (Human)	488	FUNCTION: Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits. {ECO:0000250|UniProtKB:Q3U6K5}.		cell differentiation [GO:0030154]; motile cilium assembly [GO:0044458]; spermatogenesis [GO:0007283]	extracellular region [GO:0005576]; sperm connecting piece [GO:0097224]	myosin light chain binding [GO:0032027]	extracellular region [GO:0005576]; sperm connecting piece [GO:0097224]; myosin light chain binding [GO:0032027]; cell differentiation [GO:0030154]; motile cilium assembly [GO:0044458]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q3U6K5}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q3U6K5}. Note=Specifically localizes to the segmented columns and the capitulum of the sperm connecting piece. {ECO:0000250|UniProtKB:Q3U6K5}.
Q9NWV4	reviewed	CZIB_HUMAN	CXXC motif containing zinc binding protein (UPF0587 protein C1orf123)	CZIB C1orf123	Homo sapiens (Human)	160					zinc ion binding [GO:0008270]	zinc ion binding [GO:0008270]	
Q9NWW0	reviewed	HPIP_HUMAN	Host cell factor C1 regulator 1 (HCF-1 beta-propeller-interacting protein)	HCFC1R1 HPIP	Homo sapiens (Human)	138	FUNCTION: Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. {ECO:0000269|PubMed:12235138}.			cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]		cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12235138}. Nucleus {ECO:0000269|PubMed:12235138}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.
Q9NX08	reviewed	COMD8_HUMAN	COMM domain-containing protein 8	COMMD8 MDS022	Homo sapiens (Human)	183	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.			cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
Q9NX20	reviewed	RM16_HUMAN	Large ribosomal subunit protein uL16m (39S ribosomal protein L16, mitochondrial) (L16mt) (MRP-L16)	MRPL16 PNAS-111	Homo sapiens (Human)	251			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9NX38	reviewed	ABITM_HUMAN	Protein Abitram (Actin-binding transcription modulator) (Protein Simiate)	ABITRAM C9orf6 FAM206A	Homo sapiens (Human)	181	FUNCTION: Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons. {ECO:0000250|UniProtKB:Q80ZQ9}.	MISCELLANEOUS: Depletion of ABITRAM by siRNA or neutralizing antibodies results in cell death within a few hours. {ECO:0000305|PubMed:24349419}.	dendrite morphogenesis [GO:0048813]; regulation of actin filament polymerization [GO:0030833]; regulation of filopodium assembly [GO:0051489]	dendrite [GO:0030425]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]	dendrite [GO:0030425]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; dendrite morphogenesis [GO:0048813]; regulation of actin filament polymerization [GO:0030833]; regulation of filopodium assembly [GO:0051489]	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q80ZQ9}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q80ZQ9}. Nucleus {ECO:0000250|UniProtKB:Q80ZQ9}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q80ZQ9}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q80ZQ9}. Note=Localizes to somata and dendrites in cortical neurons (By similarity). Colocalizes with G- and F-actin in lamellipodia (By similarity). Colocalizes in the nucleus with PTK2 (By similarity). {ECO:0000250|UniProtKB:Q80ZQ9}.
Q9NX45	reviewed	SOLH2_HUMAN	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2	SOHLH2 TEB1	Homo sapiens (Human)	425	FUNCTION: Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity). {ECO:0000250|UniProtKB:Q6IUP1, ECO:0000250|UniProtKB:Q9D489}.		cell differentiation [GO:0030154]; oocyte differentiation [GO:0009994]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; cell differentiation [GO:0030154]; oocyte differentiation [GO:0009994]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D489, ECO:0000255|PROSITE-ProRule:PRU00981}. Cytoplasm {ECO:0000250|UniProtKB:Q9D489}. Note=Translocates from the cytoplasm into the nucleus and the translocation is dependent on SOHLH1 expression. {ECO:0000250|UniProtKB:Q9D489}.
Q9NXF1	reviewed	TEX10_HUMAN	Testis-expressed protein 10	TEX10 L18 Nbla10363	Homo sapiens (Human)	929	FUNCTION: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). {ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}.			mitochondrion [GO:0005739]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		mitochondrion [GO:0005739]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q3URQ0}. Cytoplasm {ECO:0000250|UniProtKB:Q3URQ0}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:21326211}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250|UniProtKB:Q3URQ0}.
Q9NXF7	reviewed	DCA16_HUMAN	DDB1- and CUL4-associated factor 16	DCAF16 C4orf30	Homo sapiens (Human)	216	FUNCTION: Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31209349}.		protein ubiquitination [GO:0016567]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31209349}.
Q9NXH3	reviewed	PP14D_HUMAN	Protein phosphatase 1 regulatory subunit 14D (Gastrointestinal and brain-specific PP1-inhibitory protein 1) (GBPI-1)	PPP1R14D GBPI	Homo sapiens (Human)	145	FUNCTION: Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. {ECO:0000269|PubMed:12974676}.		negative regulation of protein serine/threonine phosphatase activity [GO:1905183]; positive regulation of protein serine/threonine phosphatase activity [GO:1905184]; regulation of phosphorylation [GO:0042325]	cytoplasm [GO:0005737]	protein serine/threonine phosphatase inhibitor activity [GO:0004865]	cytoplasm [GO:0005737]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; negative regulation of protein serine/threonine phosphatase activity [GO:1905183]; positive regulation of protein serine/threonine phosphatase activity [GO:1905184]; regulation of phosphorylation [GO:0042325]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q9NXK6	reviewed	PAQR5_HUMAN	Membrane progestin receptor gamma (mPR gamma) (Membrane progesterone P4 receptor gamma) (Membrane progesterone receptor gamma) (Progesterone and adipoQ receptor family member 5) (Progestin and adipoQ receptor family member 5) (Progestin and adipoQ receptor family member V)	PAQR5 MPRG	Homo sapiens (Human)	330	FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167). {ECO:0000269|PubMed:12601167, ECO:0000303|PubMed:23763432}.	MISCELLANEOUS: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). {ECO:0000303|PubMed:23763432}.	oogenesis [GO:0048477]	plasma membrane [GO:0005886]	signaling receptor activity [GO:0038023]; steroid binding [GO:0005496]	plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; steroid binding [GO:0005496]; oogenesis [GO:0048477]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:23763432}; Multi-pass membrane protein {ECO:0000255}.
Q9NXK8	reviewed	FXL12_HUMAN	F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12)	FBXL12 FBL12	Homo sapiens (Human)	326	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia. {ECO:0000269|PubMed:23707388}.		protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]		cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	
Q9NXL2	reviewed	ARH38_HUMAN	Rho guanine nucleotide exchange factor 38	ARHGEF38	Homo sapiens (Human)	777	FUNCTION: May act as a guanine-nucleotide releasing factor. {ECO:0000250}.			cytoplasm [GO:0005737]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor activity [GO:0005085]	
Q9NXL6	reviewed	SIDT1_HUMAN	SID1 transmembrane family member 1	SIDT1	Homo sapiens (Human)	827	FUNCTION: In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. {ECO:0000250|UniProtKB:Q6AXF6}.		RNA transport [GO:0050658]	lysosome [GO:0005764]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; double-stranded RNA binding [GO:0003725]; RNA transmembrane transporter activity [GO:0051033]	lysosome [GO:0005764]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; double-stranded RNA binding [GO:0003725]; RNA transmembrane transporter activity [GO:0051033]; RNA transport [GO:0050658]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NXZ2	reviewed	DDX43_HUMAN	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.4.13) (Cancer/testis antigen 13) (CT13) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen)	DDX43 HAGE	Homo sapiens (Human)	648					ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	
Q9NY35	reviewed	CLDN1_HUMAN	Claudin domain-containing protein 1 (Membrane protein GENX-3745)	CLDND1 C3orf4 HSPC174 PSEC0054 UNQ2511/PRO6000	Homo sapiens (Human)	253				apical plasma membrane [GO:0016324]; cell surface [GO:0009986]		apical plasma membrane [GO:0016324]; cell surface [GO:0009986]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NY37	reviewed	ASIC5_HUMAN	Acid-sensing ion channel 5 (ASIC5) (Amiloride-sensitive cation channel 5) (Human intestine Na(+) channel) (HINaC)	ASIC5 ACCN5 HINAC	Homo sapiens (Human)	505	FUNCTION: Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride. {ECO:0000269|PubMed:10767424}.		sodium ion transmembrane transport [GO:0035725]	plasma membrane [GO:0005886]	ligand-gated sodium channel activity [GO:0015280]; proton channel activity [GO:0015252]	plasma membrane [GO:0005886]; ligand-gated sodium channel activity [GO:0015280]; proton channel activity [GO:0015252]; sodium ion transmembrane transport [GO:0035725]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10767424}; Multi-pass membrane protein {ECO:0000269|PubMed:10767424}.
Q9NY43	reviewed	BARH2_HUMAN	BarH-like 2 homeobox protein	BARHL2	Homo sapiens (Human)	387	FUNCTION: Potential regulator of neural basic helix-loop-helix genes. {ECO:0000250}.		amacrine cell differentiation [GO:0035881]; cell fate determination [GO:0001709]; neuron migration [GO:0001764]; positive regulation of translation [GO:0045727]; regulation of axon extension [GO:0030516]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; amacrine cell differentiation [GO:0035881]; cell fate determination [GO:0001709]; neuron migration [GO:0001764]; positive regulation of translation [GO:0045727]; regulation of axon extension [GO:0030516]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NY57	reviewed	ST32B_HUMAN	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (Yet another novel kinase 2)	STK32B YANK2 UNQ3003/PRO9744	Homo sapiens (Human)	414		MISCELLANEOUS: [Isoform 2]: It is unsure whether Met-1 or Met-3 is the initiator. {ECO:0000305}.	intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]		ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]	
Q9NYF5	reviewed	FA13B_HUMAN	Protein FAM13B (GAP-like protein N61)	FAM13B C5orf5 FAM13B1	Homo sapiens (Human)	915			regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	
Q9NYL4	reviewed	FKB11_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP11 (PPIase FKBP11) (EC 5.2.1.8) (19 kDa FK506-binding protein) (19 kDa FKBP) (FKBP-19) (FK506-binding protein 11) (FKBP-11) (Rotamase)	FKBP11 FKBP19 UNQ336/PRO535	Homo sapiens (Human)	201	FUNCTION: PPIases accelerate the folding of proteins during protein synthesis.		chaperone-mediated protein folding [GO:0061077]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; chaperone-mediated protein folding [GO:0061077]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NYL9	reviewed	TMOD3_HUMAN	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)	TMOD3	Homo sapiens (Human)	352	FUNCTION: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; erythrocyte development [GO:0048821]; mitotic cell cycle phase transition [GO:0044772]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of mitotic cell cycle phase transition [GO:1901992]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865]	actin binding [GO:0003779]; cadherin binding involved in cell-cell adhesion [GO:0098641]; tropomyosin binding [GO:0005523]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865]; actin binding [GO:0003779]; cadherin binding involved in cell-cell adhesion [GO:0098641]; tropomyosin binding [GO:0005523]; actin filament organization [GO:0007015]; erythrocyte development [GO:0048821]; mitotic cell cycle phase transition [GO:0044772]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of mitotic cell cycle phase transition [GO:1901992]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q9NYM9	reviewed	BET1L_HUMAN	BET1-like protein (Golgi SNARE with a size of 15 kDa) (GOS-15) (GS15) (Vesicle transport protein GOS15)	BET1L GS15	Homo sapiens (Human)	111	FUNCTION: Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity). {ECO:0000250|UniProtKB:O35152}.		protein transport [GO:0015031]; regulation of retrograde vesicle-mediated transport, Golgi to ER [GO:2000156]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SNARE complex [GO:0031201]	SNAP receptor activity [GO:0005484]	cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SNARE complex [GO:0031201]; SNAP receptor activity [GO:0005484]; protein transport [GO:0015031]; regulation of retrograde vesicle-mediated transport, Golgi to ER [GO:2000156]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Note=Present throughout the Golgi apparatus, with increasing concentration from cis-Golgi to the trans-Golgi face of the stacks. {ECO:0000250}.
Q9NYN1	reviewed	RASLC_HUMAN	Ras-like protein family member 12 (EC 3.6.5.2) (Ras-like protein Ris)	RASL12 RIS	Homo sapiens (Human)	266				plasma membrane [GO:0005886]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	
Q9NYV8	reviewed	T2R14_HUMAN	Taste receptor type 2 member 14 (T2R14) (Taste receptor family B member 1) (TRB1)	TAS2R14	Homo sapiens (Human)	317	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NYV9	reviewed	T2R13_HUMAN	Taste receptor type 2 member 13 (T2R13) (Taste receptor family B member 3) (TRB3)	TAS2R13	Homo sapiens (Human)	303	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; positive regulation of cytokinesis [GO:0032467]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; positive regulation of cytokinesis [GO:0032467]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NYW2	reviewed	TA2R8_HUMAN	Taste receptor type 2 member 8 (T2R8) (Taste receptor family B member 5) (TRB5)	TAS2R8	Homo sapiens (Human)	309	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NYW3	reviewed	TA2R7_HUMAN	Taste receptor type 2 member 7 (T2R7) (Taste receptor family B member 4) (TRB4)	TAS2R7	Homo sapiens (Human)	318	FUNCTION: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.	MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NYW6	reviewed	TA2R3_HUMAN	Taste receptor type 2 member 3 (T2R3)	TAS2R3	Homo sapiens (Human)	316	FUNCTION: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. {ECO:0000269|PubMed:10761934, ECO:0000269|PubMed:10761935}.	MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NYW7	reviewed	TA2R1_HUMAN	Taste receptor type 2 member 1 (T2R1) (Taste receptor family B member 7) (TRB7)	TAS2R1	Homo sapiens (Human)	299	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	membrane [GO:0016020]; plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	membrane [GO:0016020]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NZ32	reviewed	ARP10_HUMAN	Actin-related protein 10 (Actin-related protein 11) (hARP11)	ACTR10 ACTR11 ARP10 ARP11	Homo sapiens (Human)	417	FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:I3LHK5}.		retrograde axonal transport of mitochondrion [GO:0098958]	axon cytoplasm [GO:1904115]; azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]		axon cytoplasm [GO:1904115]; azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; retrograde axonal transport of mitochondrion [GO:0098958]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:I3LHK5}.
Q9NZH5	reviewed	PTTG2_HUMAN	Securin-2 (Pituitary tumor-transforming gene 2 protein)	PTTG2	Homo sapiens (Human)	202			chromosome organization [GO:0051276]; homologous chromosome segregation [GO:0045143]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; SH3 domain binding [GO:0017124]; chromosome organization [GO:0051276]; homologous chromosome segregation [GO:0045143]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q9NZL6	reviewed	RGL1_HUMAN	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1)	RGL1 KIAA0959 RGL	Homo sapiens (Human)	768	FUNCTION: Probable guanine nucleotide exchange factor.		Ras protein signal transduction [GO:0007265]; small GTPase mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; Ras protein signal transduction [GO:0007265]; small GTPase mediated signal transduction [GO:0007264]	
Q9NZQ0	reviewed	DJC27_HUMAN	DnaJ homolog subfamily C member 27 (Rab and DnaJ domain-containing protein)	DNAJC27 RABJS RBJ	Homo sapiens (Human)	273	FUNCTION: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. {ECO:0000250|UniProtKB:Q8CFP6}.	MISCELLANEOUS: DNAJC27/RBJ knockdown in several colorectal cancer cell lines is correlated to inhibition of MEK/ERK activation, cell proliferation, colony formation and in vivo tumor growth. {ECO:0000269|PubMed:24746703}.	intracellular protein transport [GO:0006886]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of MAPK export from nucleus [GO:0071701]	nucleus [GO:0005634]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of MAPK export from nucleus [GO:0071701]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8CFP6}.
Q9NZQ9	reviewed	TMOD4_HUMAN	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod)	TMOD4	Homo sapiens (Human)	345	FUNCTION: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.		actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]	cytoskeleton [GO:0005856]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865]	actin binding [GO:0003779]; tropomyosin binding [GO:0005523]	cytoskeleton [GO:0005856]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865]; actin binding [GO:0003779]; tropomyosin binding [GO:0005523]; actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25250574}. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). {ECO:0000269|PubMed:25250574}.
Q9NZT2	reviewed	OGFR_HUMAN	Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor)	OGFR	Homo sapiens (Human)	677	FUNCTION: Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.		regulation of cell growth [GO:0001558]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]	opioid growth factor receptor activity [GO:0140625]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; opioid growth factor receptor activity [GO:0140625]; regulation of cell growth [GO:0001558]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=The OGF/OGFR complex is probably translocated to the nucleus.
Q9NZW5	reviewed	PALS2_HUMAN	Protein PALS2 (MAGUK p55 subfamily member 6) (Membrane protein, palmitoylated 6) (Veli-associated MAGUK 1) (VAM-1)	PALS2 MPP6 VAM1	Homo sapiens (Human)	540			protein-containing complex assembly [GO:0065003]	cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]		cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex assembly [GO:0065003]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q9P015	reviewed	RM15_HUMAN	Large ribosomal subunit protein uL15m (39S ribosomal protein L15, mitochondrial) (L15mt) (MRP-L15)	MRPL15 HSPC145	Homo sapiens (Human)	296			cellular response to leukemia inhibitory factor [GO:1990830]; mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular response to leukemia inhibitory factor [GO:1990830]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9P031	reviewed	TAP26_HUMAN	Thyroid transcription factor 1-associated protein 26 (TTF-1-associated protein 26) (Coiled-coil domain-containing protein 59) (TTF-1-associated protein BR2)	CCDC59 BR22 TAP26 HSPC128	Homo sapiens (Human)	241	FUNCTION: Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities. {ECO:0000269|PubMed:12882447, ECO:0000269|PubMed:16630564}.			nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9P0J6	reviewed	RM36_HUMAN	Large ribosomal subunit protein bL36m (39S ribosomal protein L36, mitochondrial) (L36mt) (MRP-L36) (BRCA1-interacting protein 1)	MRPL36 BRIP1	Homo sapiens (Human)	103			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379}.
Q9P0M4	reviewed	IL17C_HUMAN	Interleukin-17C (IL-17C) (Cytokine CX2)	IL17C UNQ561/PRO1122	Homo sapiens (Human)	197	FUNCTION: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. {ECO:0000269|PubMed:21993848}.		cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; inflammatory response [GO:0006954]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; inflammatory response [GO:0006954]	SUBCELLULAR LOCATION: Secreted.
Q9P0M9	reviewed	RM27_HUMAN	Large ribosomal subunit protein bL27m (39S ribosomal protein L27, mitochondrial) (L27mt) (MRP-L27)	MRPL27 HSPC250	Homo sapiens (Human)	148			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279069, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9P0S2	reviewed	COX16_HUMAN	Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial (hCOX16)	COX16 C14orf112 HSPC203 PTD019	Homo sapiens (Human)	106	FUNCTION: Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:29355485, PubMed:29381136, PubMed:33169484). Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (PubMed:29355485, PubMed:29381136). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6 (PubMed:29381136). Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines (PubMed:29381136). {ECO:0000269|PubMed:29355485, ECO:0000269|PubMed:29381136, ECO:0000269|PubMed:33169484}.	MISCELLANEOUS: No COX16 mutations have been detected in patients with cytochrome c oxidase (COX) deficiency. {ECO:0000269|PubMed:15596615}.	mitochondrial cytochrome c oxidase assembly [GO:0033617]	mitochondrial inner membrane [GO:0005743]		mitochondrial inner membrane [GO:0005743]; mitochondrial cytochrome c oxidase assembly [GO:0033617]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:29355485, ECO:0000269|PubMed:29381136}; Single-pass membrane protein {ECO:0000305|PubMed:29381136}.
Q9P104	reviewed	DOK5_HUMAN	Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)	DOK5 C20orf180	Homo sapiens (Human)	306	FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.		neuron differentiation [GO:0030182]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]; cytosol [GO:0005829]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuron differentiation [GO:0030182]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	
Q9P1P5	reviewed	TAAR2_HUMAN	Trace amine-associated receptor 2 (TaR-2) (Trace amine receptor 2) (G-protein coupled receptor 58)	TAAR2 GPR58	Homo sapiens (Human)	351	FUNCTION: Orphan receptor.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9P1U0	reviewed	RPA12_HUMAN	DNA-directed RNA polymerase I subunit RPA12 (DNA-directed RNA polymerase I subunit H) (Zinc ribbon domain-containing protein 1)	POLR1H RPA12 ZNRD1	Homo sapiens (Human)	126	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.		nucleobase-containing compound metabolic process [GO:0006139]; termination of RNA polymerase I transcription [GO:0006363]	nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]	DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; nucleobase-containing compound metabolic process [GO:0006139]; termination of RNA polymerase I transcription [GO:0006363]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P32529}.
Q9P1U1	reviewed	ARP3B_HUMAN	Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4)	ACTR3B ARP11 ARP4	Homo sapiens (Human)	418	FUNCTION: Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. {ECO:0000269|PubMed:14651955}.			cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]	actin binding [GO:0003779]; ATP binding [GO:0005524]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; actin binding [GO:0003779]; ATP binding [GO:0005524]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}.
Q9P1Y6	reviewed	PHRF1_HUMAN	PHD and RING finger domain-containing protein 1	PHRF1 KIAA1542	Homo sapiens (Human)	1649			protein ubiquitination [GO:0016567]	membrane [GO:0016020]	metal ion binding [GO:0046872]; RNA polymerase binding [GO:0070063]	membrane [GO:0016020]; metal ion binding [GO:0046872]; RNA polymerase binding [GO:0070063]; protein ubiquitination [GO:0016567]	
Q9P203	reviewed	BTBD7_HUMAN	BTB/POZ domain-containing protein 7	BTBD7 KIAA1525	Homo sapiens (Human)	1132	FUNCTION: Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}.		morphogenesis of a branching epithelium [GO:0061138]; regulation of branching involved in salivary gland morphogenesis [GO:0060693]	nucleus [GO:0005634]		nucleus [GO:0005634]; morphogenesis of a branching epithelium [GO:0061138]; regulation of branching involved in salivary gland morphogenesis [GO:0060693]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9P206	reviewed	K1522_HUMAN	Uncharacterized protein KIAA1522	KIAA1522	Homo sapiens (Human)	1035			cell differentiation [GO:0030154]			cell differentiation [GO:0030154]	
Q9P242	reviewed	NYAP2_HUMAN	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2	NYAP2 KIAA1486	Homo sapiens (Human)	653	FUNCTION: Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}.		neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]			neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]	
Q9P244	reviewed	LRFN1_HUMAN	Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2)	LRFN1 KIAA1484 SALM2	Homo sapiens (Human)	771	FUNCTION: Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}.			cell surface [GO:0009986]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]		cell surface [GO:0009986]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Postsynaptic density membrane {ECO:0000250}. Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane. {ECO:0000250}.
Q9P260	reviewed	RELCH_HUMAN	RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats)	RELCH KIAA1468	Homo sapiens (Human)	1216	FUNCTION: Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}.		intracellular cholesterol transport [GO:0032367]	recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]		recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; intracellular cholesterol transport [GO:0032367]	SUBCELLULAR LOCATION: Recycling endosome {ECO:0000269|PubMed:29514919}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:29514919}. Note=Translocated to the trans-Golgi network area in an OSBP-dependent manner (PubMed:29514919). Colocalizes with RAB11A in recycling endosomes (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity). {ECO:0000250|UniProtKB:Q148V7, ECO:0000269|PubMed:29514919}.
Q9P265	reviewed	DIP2B_HUMAN	Disco-interacting protein 2 homolog B (DIP2 homolog B)	DIP2B KIAA1463	Homo sapiens (Human)	1576	FUNCTION: Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}.		negative regulation of axon extension [GO:0030517]; nervous system development [GO:0007399]; positive regulation of peptidyl-lysine acetylation [GO:2000758]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perikaryon [GO:0043204]	alpha-tubulin binding [GO:0043014]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perikaryon [GO:0043204]; alpha-tubulin binding [GO:0043014]; negative regulation of axon extension [GO:0030517]; nervous system development [GO:0007399]; positive regulation of peptidyl-lysine acetylation [GO:2000758]	SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000250|UniProtKB:Q3UH60}. Cell projection, axon {ECO:0000250|UniProtKB:Q3UH60}. Perikaryon {ECO:0000250|UniProtKB:Q3UH60}.
Q9P291	reviewed	ARMX1_HUMAN	Armadillo repeat-containing X-linked protein 1 (ARM protein lost in epithelial cancers on chromosome X 1) (Protein ALEX1)	ARMCX1 ALEX1 AD032	Homo sapiens (Human)	453	FUNCTION: Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1. {ECO:0000250|UniProtKB:Q9CX83}.		hematopoietic stem cell homeostasis [GO:0061484]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; hematopoietic stem cell homeostasis [GO:0061484]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9CX83}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9CX83}; Single-pass membrane protein {ECO:0000255}.
Q9P299	reviewed	COPZ2_HUMAN	Coatomer subunit zeta-2 (Zeta-2-coat protein) (Zeta-2 COP)	COPZ2	Homo sapiens (Human)	210	FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. {ECO:0000250|UniProtKB:P53600}.		intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cis-Golgi network [GO:0005801]; COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]		cis-Golgi network [GO:0005801]; COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows a significant preference for ERGIC and cis-Golgi apparatus compared with trans-Golgi network. {ECO:0000250}.
Q9P2D8	reviewed	UNC79_HUMAN	Protein unc-79 homolog	UNC79 KIAA1409	Homo sapiens (Human)	2635	FUNCTION: Auxiliary subunit of the NALCN sodium channel complex, a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability. Activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. {ECO:0000250|UniProtKB:Q8BLN6}.			plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32494638}; Multi-pass membrane protein {ECO:0000255}.
Q9P2E7	reviewed	PCD10_HUMAN	Protocadherin-10	PCDH10 KIAA1400	Homo sapiens (Human)	1040	FUNCTION: Potential calcium-dependent cell-adhesion protein.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9P2F8	reviewed	SI1L2_HUMAN	Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2)	SIPA1L2 KIAA1389	Homo sapiens (Human)	1722			regulation of small GTPase mediated signal transduction [GO:0051056]	cytoplasm [GO:0005737]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; GTPase activator activity [GO:0005096]; regulation of small GTPase mediated signal transduction [GO:0051056]	
Q9P2J8	reviewed	ZN624_HUMAN	Zinc finger protein 624	ZNF624 KIAA1349	Homo sapiens (Human)	865	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9P2J9	reviewed	PDP2_HUMAN	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial (PDP 2) (EC 3.1.3.43) (Pyruvate dehydrogenase phosphatase catalytic subunit 2) (PDPC 2)	PDP2 KIAA1348	Homo sapiens (Human)	529	FUNCTION: Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. {ECO:0000250}.			mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	[pyruvate dehydrogenase (lipoamide)] phosphatase activity [GO:0004741]; [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity [GO:0019909]; metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; [pyruvate dehydrogenase (lipoamide)] phosphatase activity [GO:0004741]; [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity [GO:0019909]; metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
Q9P2P1	reviewed	NYNRI_HUMAN	Protein NYNRIN (NYN domain and retroviral integrase catalytic domain-containing protein) (Protein cousin of GIN1)	NYNRIN CGIN1 KIAA1305	Homo sapiens (Human)	1898		MISCELLANEOUS: The gene encoding this protein may have arisen from the fusion of a cellular gene with retroviral sequences prior to the marsupial-eutherian split. Sequence and structural analyses suggest that the integrase catalytic domain is inactive.	DNA integration [GO:0015074]; DNA repair [GO:0006281]	cytoplasmic ribonucleoprotein granule [GO:0036464]; membrane [GO:0016020]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521]; RNA-DNA hybrid ribonuclease activity [GO:0004523]	cytoplasmic ribonucleoprotein granule [GO:0036464]; membrane [GO:0016020]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; DNA integration [GO:0015074]; DNA repair [GO:0006281]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9P2V4	reviewed	LRIT1_HUMAN	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 (Leucine-rich repeat-containing protein 21) (Photoreceptor-associated LRR superfamily protein) (Retina-specific protein PAL)	LRIT1 LRRC21 PAL	Homo sapiens (Human)	623	FUNCTION: Possible role in phototransduction. {ECO:0000303|PubMed:10777785}.			endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9JMH2}; Single-pass type I membrane protein {ECO:0000250}.
Q9P2Z0	reviewed	THA10_HUMAN	THAP domain-containing protein 10	THAP10	Homo sapiens (Human)	257			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q9QC07	reviewed	POK18_HUMAN	Endogenous retrovirus group K member 18 Pol protein (HERV-K(C1a) Pol protein) (HERV-K110 Pol protein) (HERV-K18 Pol protein) (HERV-K_1q23.3 provirus ancestral Pol protein) [Includes: Reverse transcriptase (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4)]	ERVK-18	Homo sapiens (Human)	812	FUNCTION: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein precursors. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; MISCELLANEOUS: Exact N-terminus of this protein has not been formally described.; MISCELLANEOUS: Intragenic, in the first intron of CD48 gene.	DNA integration [GO:0015074]; DNA repair [GO:0006281]		DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]	DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]; DNA integration [GO:0015074]; DNA repair [GO:0006281]	
Q9UBG7	reviewed	RBPJL_HUMAN	Recombining binding protein suppressor of hairless-like protein (Transcription factor RBP-L)	RBPJL RBPL RBPSUHL	Homo sapiens (Human)	517	FUNCTION: Putative transcription factor, which cooperates with EBNA2 to activate transcription. {ECO:0000250}.		signal transduction [GO:0007165]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UBL0	reviewed	ARP21_HUMAN	cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein)	ARPP21 TARPP	Homo sapiens (Human)	812	FUNCTION: Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000250}.			cytoplasm [GO:0005737]	calmodulin binding [GO:0005516]; nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; calmodulin binding [GO:0005516]; nucleic acid binding [GO:0003676]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9UBU2	reviewed	DKK2_HUMAN	Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)	DKK2 UNQ682/PRO1316	Homo sapiens (Human)	259	FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055]	extracellular space [GO:0005615]	co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019]	extracellular space [GO:0005615]; co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Secreted.
Q9UBU6	reviewed	FA8A1_HUMAN	Protein FAM8A1 (Autosomal highly conserved protein)	FAM8A1 AHCP	Homo sapiens (Human)	413	FUNCTION: Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD). {ECO:0000269|PubMed:28827405}.		ubiquitin-dependent ERAD pathway [GO:0030433]	Hrd1p ubiquitin ligase complex [GO:0000836]		Hrd1p ubiquitin ligase complex [GO:0000836]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9UDV7	reviewed	ZN282_HUMAN	Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1)	ZNF282 HUB1	Homo sapiens (Human)	671	FUNCTION: Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UDX5	reviewed	MTFP1_HUMAN	Mitochondrial fission process protein 1 (Mitochondrial 18 kDa protein) (MTP18)	MTFP1 MTP18 HSPC242 My022	Homo sapiens (Human)	166	FUNCTION: Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis. {ECO:0000269|PubMed:15155745, ECO:0000269|PubMed:15985469}.		apoptotic process [GO:0006915]; mitochondrial fission [GO:0000266]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; apoptotic process [GO:0006915]; mitochondrial fission [GO:0000266]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:15155745, ECO:0000305|PubMed:15985469}; Multi-pass membrane protein {ECO:0000305|PubMed:15155745, ECO:0000305|PubMed:15985469}.
Q9UEE9	reviewed	CFDP1_HUMAN	Craniofacial development protein 1 (Bucentaur)	CFDP1 BCNT CENP-29	Homo sapiens (Human)	299	FUNCTION: May play a role during embryogenesis. {ECO:0000250}.		cell adhesion [GO:0007155]; chromatin remodeling [GO:0006338]; fibroblast apoptotic process [GO:0044346]; negative regulation of fibroblast apoptotic process [GO:2000270]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]	kinetochore [GO:0000776]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]		kinetochore [GO:0000776]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]; cell adhesion [GO:0007155]; chromatin remodeling [GO:0006338]; fibroblast apoptotic process [GO:0044346]; negative regulation of fibroblast apoptotic process [GO:2000270]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]	SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
Q9UF02	reviewed	CCG5_HUMAN	Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5)	CACNG5	Homo sapiens (Human)	275	FUNCTION: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250}.		neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA receptor activity [GO:2000311]; transmission of nerve impulse [GO:0019226]	AMPA glutamate receptor complex [GO:0032281]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]	channel regulator activity [GO:0016247]; monoatomic ion transmembrane transporter activity [GO:0015075]; voltage-gated calcium channel activity [GO:0005245]	AMPA glutamate receptor complex [GO:0032281]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; channel regulator activity [GO:0016247]; monoatomic ion transmembrane transporter activity [GO:0015075]; voltage-gated calcium channel activity [GO:0005245]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA receptor activity [GO:2000311]; transmission of nerve impulse [GO:0019226]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic density membrane {ECO:0000250}.
Q9UGQ2	reviewed	FLOWR_HUMAN	Calcium channel flower homolog (Calcium channel flower domain-containing protein 1)	CACFD1 C9orf7 PSEC0107 PSEC0248 UNQ3071/PRO9903	Homo sapiens (Human)	172			vesicle-mediated transport [GO:0016192]	membrane [GO:0016020]		membrane [GO:0016020]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9UH62	reviewed	ARMX3_HUMAN	Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3)	ARMCX3 ALEX3 BM-017 UNQ2517/PRO6007	Homo sapiens (Human)	379	FUNCTION: Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}.		axonal transport of mitochondrion [GO:0019896]; mitochondrion organization [GO:0007005]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]	axon cytoplasm [GO:1904115]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]		axon cytoplasm [GO:1904115]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; axonal transport of mitochondrion [GO:0019896]; mitochondrion organization [GO:0007005]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8BHS6}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8BHS6}. Nucleus {ECO:0000250|UniProtKB:Q8BHS6}.
Q9UHA3	reviewed	RLP24_HUMAN	Probable ribosome biogenesis protein RLP24 (Ribosomal L24 domain-containing protein 1) (Ribosomal protein L24-like)	RSL24D1 C15orf15 RPL24L My024	Homo sapiens (Human)	163	FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity). {ECO:0000250|UniProtKB:Q07915}.		ribosomal large subunit biogenesis [GO:0042273]; translation [GO:0006412]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]	structural constituent of ribosome [GO:0003735]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; structural constituent of ribosome [GO:0003735]; ribosomal large subunit biogenesis [GO:0042273]; translation [GO:0006412]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:35354024}.
Q9UHF5	reviewed	IL17B_HUMAN	Interleukin-17B (IL-17B) (Cytokine Zcyto7) (Interleukin-20) (IL-20) (Neuronal interleukin-17-related factor)	IL17B IL20 NIRF ZCYTO7 UNQ516/PRO1031	Homo sapiens (Human)	180	FUNCTION: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.		cell-cell signaling [GO:0007267]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]	extracellular space [GO:0005615]	cytokine activity [GO:0005125]	extracellular space [GO:0005615]; cytokine activity [GO:0005125]; cell-cell signaling [GO:0007267]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]	SUBCELLULAR LOCATION: Secreted.
Q9UHP9	reviewed	SMPX_HUMAN	Small muscular protein (Stretch-responsive skeletal muscle protein)	SMPX SRMX	Homo sapiens (Human)	88	FUNCTION: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. {ECO:0000250}.		striated muscle contraction [GO:0006941]	costamere [GO:0043034]; M band [GO:0031430]; muscle tendon junction [GO:0005927]; nucleus [GO:0005634]		costamere [GO:0043034]; M band [GO:0031430]; muscle tendon junction [GO:0005927]; nucleus [GO:0005634]; striated muscle contraction [GO:0006941]	
Q9UHQ4	reviewed	BAP29_HUMAN	B-cell receptor-associated protein 29 (BCR-associated protein 29) (Bap29)	BCAP29 BAP29	Homo sapiens (Human)	241	FUNCTION: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity). {ECO:0000250}.		apoptotic process [GO:0006915]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; osteoblast differentiation [GO:0001649]; protein localization to endoplasmic reticulum exit site [GO:0070973]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]		endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; apoptotic process [GO:0006915]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; osteoblast differentiation [GO:0001649]; protein localization to endoplasmic reticulum exit site [GO:0070973]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9UHR6	reviewed	ZNHI2_HUMAN	Zinc finger HIT domain-containing protein 2 (Protein FON)	ZNHIT2 C11orf5	Homo sapiens (Human)	403	FUNCTION: May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (PubMed:28561026). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (PubMed:28561026). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:28561026}.				metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q9UHV5	reviewed	RPGFL_HUMAN	Rap guanine nucleotide exchange factor-like 1 (Link guanine nucleotide exchange factor II) (Link GEFII)	RAPGEFL1	Homo sapiens (Human)	662	FUNCTION: Probable guanine nucleotide exchange factor (GEF).		G protein-coupled receptor signaling pathway [GO:0007186]; nervous system development [GO:0007399]; Ras protein signal transduction [GO:0007265]	membrane [GO:0016020]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	membrane [GO:0016020]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; G protein-coupled receptor signaling pathway [GO:0007186]; nervous system development [GO:0007399]; Ras protein signal transduction [GO:0007265]	
Q9UHW5	reviewed	GPN3_HUMAN	GPN-loop GTPase 3 (ATP-binding domain 1 family member C)	GPN3 ATPBD1C AD-009 UNQ1876/PRO4319	Homo sapiens (Human)	284	FUNCTION: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. {ECO:0000269|PubMed:21768307}.			protein-containing complex [GO:0032991]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	protein-containing complex [GO:0032991]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	
Q9UIF3	reviewed	TEKT2_HUMAN	Tektin-2 (Tektin-t) (Testicular tektin) (Testicular tektin B1-like protein) (TEKTB1) (Tektin-B1)	TEKT2	Homo sapiens (Human)	430	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme (PubMed:36191189). Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. {ECO:0000250|UniProtKB:Q922G7, ECO:0000269|PubMed:36191189}.		cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]	axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; motile cilium [GO:0031514]; nucleus [GO:0005634]		axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; motile cilium [GO:0031514]; nucleus [GO:0005634]; cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q922G7}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q922G7}. Note=Colocalized with CCDC172 at the perinuclear region. {ECO:0000250|UniProtKB:Q922G7}.
Q9UII5	reviewed	ZN107_HUMAN	Zinc finger protein 107 (Zinc finger protein 588) (Zinc finger protein ZFD25)	ZNF107 ZFD25 ZNF588	Homo sapiens (Human)	783	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UIM3	reviewed	FKBPL_HUMAN	FK506-binding protein-like (WAF-1/CIP1 stabilizing protein 39) (WISp39)	FKBPL DIR1 NG7	Homo sapiens (Human)	349	FUNCTION: May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21. {ECO:0000269|PubMed:15664193}.		regulation of blood vessel branching [GO:1905553]; response to radiation [GO:0009314]	cytosol [GO:0005829]; extracellular region [GO:0005576]		cytosol [GO:0005829]; extracellular region [GO:0005576]; regulation of blood vessel branching [GO:1905553]; response to radiation [GO:0009314]	
Q9UJ04	reviewed	TSYL4_HUMAN	Testis-specific Y-encoded-like protein 4 (TSPY-like protein 4)	TSPYL4 KIAA0721	Homo sapiens (Human)	414			nucleosome assembly [GO:0006334]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; nucleosome assembly [GO:0006334]	
Q9UJ42	reviewed	GP160_HUMAN	Probable G-protein coupled receptor 160 (G-protein coupled receptor GPCR1) (hGPCR1)	GPR160 GPCR150	Homo sapiens (Human)	338	FUNCTION: Orphan receptor.			plasma membrane [GO:0005886]; receptor complex [GO:0043235]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled receptor activity [GO:0004930]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9UJ99	reviewed	CAD22_HUMAN	Cadherin-22 (Pituitary and brain cadherin) (PB-cadherin)	CDH22 C20orf25	Homo sapiens (Human)	828	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity). {ECO:0000250}.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	adherens junction [GO:0005912]; catenin complex [GO:0016342]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9UJG1	reviewed	MSPD1_HUMAN	Motile sperm domain-containing protein 1	MOSPD1	Homo sapiens (Human)	213	FUNCTION: Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. {ECO:0000250|UniProtKB:Q8VEL0}.		cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]		cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8VEL0}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8VEL0}; Multi-pass membrane protein {ECO:0000255}.
Q9UJK0	reviewed	TSR3_HUMAN	18S rRNA aminocarboxypropyltransferase (EC 2.5.1.-) (20S S rRNA accumulation protein 3 homolog) (HsTsr3)	TSR3 C16orf42 UND313L	Homo sapiens (Human)	312	FUNCTION: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable). {ECO:0000305|PubMed:27084949}.		enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; maturation of SSU-rRNA [GO:0030490]; rRNA modification [GO:0000154]	cytosol [GO:0005829]	18S rRNA aminocarboxypropyltransferase activity [GO:0106388]; S-adenosyl-L-methionine binding [GO:1904047]; transferase activity [GO:0016740]	cytosol [GO:0005829]; 18S rRNA aminocarboxypropyltransferase activity [GO:0106388]; S-adenosyl-L-methionine binding [GO:1904047]; transferase activity [GO:0016740]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; maturation of SSU-rRNA [GO:0030490]; rRNA modification [GO:0000154]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q12094, ECO:0000255|HAMAP-Rule:MF_03146}.
Q9UJU3	reviewed	ZN112_HUMAN	Zinc finger protein 112 (Zfp-112) (Zinc finger protein 228)	ZNF112 ZFP112 ZNF228	Homo sapiens (Human)	913	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UJV8	reviewed	PURG_HUMAN	Purine-rich element-binding protein gamma (Purine-rich element-binding protein G)	PURG	Homo sapiens (Human)	347			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]; synapse [GO:0045202]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; synapse [GO:0045202]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9UJW7	reviewed	ZN229_HUMAN	Zinc finger protein 229	ZNF229	Homo sapiens (Human)	825	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UK08	reviewed	GBG8_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (Gamma-9)	GNG8 GNG9 GNGT9	Homo sapiens (Human)	70	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.		cellular response to pheromone [GO:0071444]; G protein-coupled receptor signaling pathway [GO:0007186]; nose development [GO:0043584]; social behavior [GO:0035176]	heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]	G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]	heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]; cellular response to pheromone [GO:0071444]; G protein-coupled receptor signaling pathway [GO:0007186]; nose development [GO:0043584]; social behavior [GO:0035176]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q9UK11	reviewed	ZN223_HUMAN	Zinc finger protein 223	ZNF223	Homo sapiens (Human)	482	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UK13	reviewed	ZN221_HUMAN	Zinc finger protein 221	ZNF221	Homo sapiens (Human)	617	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UK85	reviewed	DKKL1_HUMAN	Dickkopf-like protein 1 (Cancer/testis antigen 34) (CT34) (Protein soggy-1) (SGY-1)	DKKL1 SGY1 UNQ735/PRO1429	Homo sapiens (Human)	242	FUNCTION: Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility. {ECO:0000250|UniProtKB:Q9QZL9}.		anatomical structure morphogenesis [GO:0009653]; canonical Wnt signaling pathway [GO:0060070]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of testosterone biosynthetic process [GO:2000225]; penetration of zona pellucida [GO:0007341]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fat cell differentiation [GO:0045600]	acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615]	co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019]	acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615]; co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019]; anatomical structure morphogenesis [GO:0009653]; canonical Wnt signaling pathway [GO:0060070]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of testosterone biosynthetic process [GO:2000225]; penetration of zona pellucida [GO:0007341]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fat cell differentiation [GO:0045600]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9QZL9}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9QZL9}. Note=Localized specifically to the crescent shaped acrosome at the apex of the sperm head. {ECO:0000250|UniProtKB:Q9QZL9}.
Q9UKB3	reviewed	DJC12_HUMAN	DnaJ homolog subfamily C member 12 (J domain-containing protein 1)	DNAJC12 JDP1	Homo sapiens (Human)	198				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: [Isoform a]: Cytoplasm {ECO:0000269|PubMed:24122553}.
Q9UKD2	reviewed	MRT4_HUMAN	mRNA turnover protein 4 homolog (Ribosome assembly factor MRTO4)	MRTO4 C1orf33 MRT4	Homo sapiens (Human)	239	FUNCTION: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. {ECO:0000269|PubMed:20083226}.		nuclear-transcribed mRNA catabolic process [GO:0000956]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]; RNA binding [GO:0003723]; nuclear-transcribed mRNA catabolic process [GO:0000956]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20083226}. Cytoplasm {ECO:0000269|PubMed:20083226}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:20083226}.
Q9UKH3	reviewed	ENK9_HUMAN	Endogenous retrovirus group K member 9 Env polyprotein (EnvK4 protein) (Envelope polyprotein) (HERV-K(C6) envelope protein) (HERV-K109 envelope protein) (HERV-K_6q14.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERVK-9	Homo sapiens (Human)	698	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: This envelope protein is encoded by a human specific provirus.; MISCELLANEOUS: ERVK-9 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.		plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.; SUBCELLULAR LOCATION: [Endogenous retrovirus group K member 9 Env polyprotein]: Virion {ECO:0000250}.
Q9UKJ0	reviewed	PILRB_HUMAN	Paired immunoglobulin-like type 2 receptor beta (Activating receptor PILR-beta) (Cell surface receptor FDFACT)	PILRB FDFACT PP1551	Homo sapiens (Human)	227	FUNCTION: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.		activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	plasma membrane [GO:0005886]	MHC class I protein binding [GO:0042288]	plasma membrane [GO:0005886]; MHC class I protein binding [GO:0042288]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9UKJ3	reviewed	GPTC8_HUMAN	G patch domain-containing protein 8	GPATCH8 GPATC8 KIAA0553	Homo sapiens (Human)	1502				nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	
Q9UKL2	reviewed	O52A1_HUMAN	Olfactory receptor 52A1 (HPFH1OR) (Odorant receptor HOR3'beta4) (Olfactory receptor OR11-319)	OR52A1	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; transmembrane signaling receptor activity [GO:0004888]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9UKL4	reviewed	CXD2_HUMAN	Gap junction delta-2 protein (Connexin-36) (Cx36) (Gap junction alpha-9 protein)	GJD2 GJA9	Homo sapiens (Human)	321	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.		cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; neuronal action potential [GO:0019228]; visual perception [GO:0007601]	connexin complex [GO:0005922]; plasma membrane [GO:0005886]; synapse [GO:0045202]	gap junction channel activity [GO:0005243]	connexin complex [GO:0005922]; plasma membrane [GO:0005886]; synapse [GO:0045202]; gap junction channel activity [GO:0005243]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; neuronal action potential [GO:0019228]; visual perception [GO:0007601]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Q9UKR3	reviewed	KLK13_HUMAN	Kallikrein-13 (EC 3.4.21.-) (Kallikrein-like protein 4) (KLK-L4)	KLK13 KLKL4	Homo sapiens (Human)	277			protein processing [GO:0016485]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]	hydrolase activity [GO:0016787]; serine-type endopeptidase activity [GO:0004252]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; hydrolase activity [GO:0016787]; serine-type endopeptidase activity [GO:0004252]; protein processing [GO:0016485]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9UKT6	reviewed	FXL21_HUMAN	Putative F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) (F-box and leucine-rich repeat protein 3B) (F-box/LRR-repeat protein 3B)	FBXL21P FBL21 FBL3 FBXL21 FBXL3B FBXL3P	Homo sapiens (Human)	434	FUNCTION: Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity). {ECO:0000250}.		entrainment of circadian clock by photoperiod [GO:0043153]; protein ubiquitination [GO:0016567]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]	ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; ubiquitin-protein transferase activity [GO:0004842]; entrainment of circadian clock by photoperiod [GO:0043153]; protein ubiquitination [GO:0016567]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly localizes in the cytosol. Present at low level in the nucleus (By similarity). {ECO:0000250}.
Q9UKU9	reviewed	ANGL2_HUMAN	Angiopoietin-related protein 2 (Angiopoietin-like protein 2)	ANGPTL2 ARP2 UNQ170/PRO196	Homo sapiens (Human)	493	FUNCTION: Induces sprouting in endothelial cells through an autocrine and paracrine action.		cell-cell signaling [GO:0007267]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	signaling receptor binding [GO:0005102]	collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; signaling receptor binding [GO:0005102]; cell-cell signaling [GO:0007267]	SUBCELLULAR LOCATION: Secreted.
Q9UKY3	reviewed	CES1P_HUMAN	Putative inactive carboxylesterase 4 (Inactive carboxylesterase 1 pseudogene 1) (Placental carboxylesterase 3) (PCE-3)	CES1P1 CES4	Homo sapiens (Human)	287	FUNCTION: Has no esterase activity. {ECO:0000305}.		anatomical structure morphogenesis [GO:0009653]; lipid catabolic process [GO:0016042]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]	carboxylic ester hydrolase activity [GO:0052689]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; carboxylic ester hydrolase activity [GO:0052689]; anatomical structure morphogenesis [GO:0009653]; lipid catabolic process [GO:0016042]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9UKZ1	reviewed	CNO11_HUMAN	CCR4-NOT transcription complex subunit 11	CNOT11 C2orf29 C40	Homo sapiens (Human)	510	FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.		nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulatory ncRNA-mediated gene silencing [GO:0031047]	CCR4-NOT complex [GO:0030014]; cytosol [GO:0005829]; nucleus [GO:0005634]		CCR4-NOT complex [GO:0030014]; cytosol [GO:0005829]; nucleus [GO:0005634]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulatory ncRNA-mediated gene silencing [GO:0031047]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Q9UL36	reviewed	ZN236_HUMAN	Zinc finger protein 236	ZNF236	Homo sapiens (Human)	1845	FUNCTION: May be involved in transcriptional regulation.	MISCELLANEOUS: [Isoform A]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cellular response to glucose stimulus [GO:0071333]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cellular response to glucose stimulus [GO:0071333]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UL58	reviewed	ZN215_HUMAN	Zinc finger protein 215 (BWSCR2-associated zinc finger protein 2) (BAZ-2) (Zinc finger protein with KRAB and SCAN domains 11)	ZNF215 BAZ2 ZKSCAN11	Homo sapiens (Human)	517	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9ULB5	reviewed	CADH7_HUMAN	Cadherin-7	CDH7 CDH7L1	Homo sapiens (Human)	785	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Q9ULE3	reviewed	DEN2A_HUMAN	DENN domain-containing protein 2A	DENND2A KIAA1277	Homo sapiens (Human)	1009	FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. {ECO:0000269|PubMed:20937701}.		protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]	guanyl-nucleotide exchange factor activity [GO:0005085]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20937701}. Note=Associated with actin filaments.
Q9ULE6	reviewed	PALD_HUMAN	Paladin	PALD1 KIAA1274 PALD	Homo sapiens (Human)	856				cytoplasm [GO:0005737]; cytosol [GO:0005829]	protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein tyrosine phosphatase activity [GO:0004725]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22354871}.
Q9ULJ7	reviewed	ANR50_HUMAN	Ankyrin repeat domain-containing protein 50	ANKRD50 KIAA1223	Homo sapiens (Human)	1429	FUNCTION: Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552).		endocytic recycling [GO:0032456]; protein transport [GO:0015031]	endosome [GO:0005768]		endosome [GO:0005768]; endocytic recycling [GO:0032456]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Endosome {ECO:0000305}.
Q9ULK2	reviewed	AT7L1_HUMAN	Ataxin-7-like protein 1 (Ataxin-7-like protein 4)	ATXN7L1 ATXN7L4 KIAA1218	Homo sapiens (Human)	861							
Q9ULK6	reviewed	RN150_HUMAN	RING finger protein 150	RNF150 KIAA1214	Homo sapiens (Human)	438			ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; membrane [GO:0016020]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9ULL5	reviewed	PRR12_HUMAN	Proline-rich protein 12	PRR12 KIAA1205	Homo sapiens (Human)	2036				neuron projection [GO:0043005]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]		neuron projection [GO:0043005]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:E9PYL2}. Postsynaptic density {ECO:0000250|UniProtKB:E9PYL2}. Synapse, synaptosome {ECO:0000250|UniProtKB:E9PYL2}.
Q9ULR5	reviewed	PAI2B_HUMAN	Polyadenylate-binding protein-interacting protein 2B (PABP-interacting protein 2B) (PAIP-2B) (Poly(A)-binding protein-interacting protein 2B)	PAIP2B KIAA1155	Homo sapiens (Human)	123	FUNCTION: Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail. {ECO:0000269|PubMed:16804161}.		negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]	cytoplasm [GO:0005737]	mRNA regulatory element binding translation repressor activity [GO:0000900]; translation repressor activity [GO:0030371]	cytoplasm [GO:0005737]; mRNA regulatory element binding translation repressor activity [GO:0000900]; translation repressor activity [GO:0030371]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]	
Q9ULS5	reviewed	TMCC3_HUMAN	Transmembrane and coiled-coil domain protein 3	TMCC3 KIAA1145	Homo sapiens (Human)	477				endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	14-3-3 protein binding [GO:0071889]; identical protein binding [GO:0042802]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; 14-3-3 protein binding [GO:0071889]; identical protein binding [GO:0042802]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24454821, ECO:0000269|PubMed:30220460}; Multi-pass membrane protein {ECO:0000255}. Note=Concentrates in discrete patches along peripheral endoplasmic reticulum tubules. {ECO:0000269|PubMed:30220460}.
Q9ULS6	reviewed	KCNS2_HUMAN	Potassium voltage-gated channel subfamily S member 2 (Delayed-rectifier K(+) channel alpha subunit 2) (Voltage-gated potassium channel subunit Kv9.2)	KCNS2 KIAA1144	Homo sapiens (Human)	477	FUNCTION: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. {ECO:0000250|UniProtKB:O35174}.		potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of delayed rectifier potassium channel activity [GO:1902259]	perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	voltage-gated potassium channel activity [GO:0005249]	perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; voltage-gated potassium channel activity [GO:0005249]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of delayed rectifier potassium channel activity [GO:1902259]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O35174}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O35174}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2. {ECO:0000250|UniProtKB:O35174}.
Q9ULZ0	reviewed	T53G3_HUMAN	TP53-target gene 3 protein (TP53-inducible gene 3 protein)	TP53TG3 TP53TG3A; TP53TG3B; TP53TG3C; TP53TG3D; TP53TG3E; TP53TG3F	Homo sapiens (Human)	124	FUNCTION: May play a significant role in p53/TP53-mediating signaling pathway. {ECO:0000269|PubMed:10534768}.	MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10534768}. Nucleus {ECO:0000269|PubMed:10534768}.
Q9UN30	reviewed	SCML1_HUMAN	Sex comb on midleg-like protein 1	SCML1	Homo sapiens (Human)	329	FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity). {ECO:0000250}.		negative regulation of DNA-templated transcription [GO:0045892]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UN66	reviewed	PCDB8_HUMAN	Protocadherin beta-8 (PCDH-beta-8) (Protocadherin-3I)	PCDHB8 PCDH3I	Homo sapiens (Human)	801	FUNCTION: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain. {ECO:0000250|UniProtKB:Q91XZ2}.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q91XZ2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q91XZ2}.
Q9UN67	reviewed	PCDBA_HUMAN	Protocadherin beta-10 (PCDH-beta-10)	PCDHB10 UNQ1906/PRO4352	Homo sapiens (Human)	800	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9UN70	reviewed	PCDGK_HUMAN	Protocadherin gamma-C3 (PCDH-gamma-C3) (Protocadherin-2) (Protocadherin-43) (PC-43)	PCDHGC3 PCDH2	Homo sapiens (Human)	934	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; synapse organization [GO:0050808]	membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9UN71	reviewed	PCDGG_HUMAN	Protocadherin gamma-B4 (PCDH-gamma-B4) (Cadherin-20) (Fibroblast cadherin-2)	PCDHGB4 CDH20 FIB2	Homo sapiens (Human)	923	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9UN75	reviewed	PCDAC_HUMAN	Protocadherin alpha-12 (PCDH-alpha-12)	PCDHA12	Homo sapiens (Human)	941	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9UNK9	reviewed	ANGE1_HUMAN	Protein angel homolog 1	ANGEL1 KIAA0759	Homo sapiens (Human)	670				cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	3'-5'-RNA exonuclease activity [GO:0000175]; eukaryotic initiation factor 4E binding [GO:0008190]; protein domain specific binding [GO:0019904]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; 3'-5'-RNA exonuclease activity [GO:0000175]; eukaryotic initiation factor 4E binding [GO:0008190]; protein domain specific binding [GO:0019904]	
Q9UNL2	reviewed	SSRG_HUMAN	Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma)	SSR3 TRAPG	Homo sapiens (Human)	185	FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.		SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Q9UNN4	reviewed	TF2AY_HUMAN	TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor)	GTF2A1L ALF GTF2A1LF	Homo sapiens (Human)	478	FUNCTION: May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. {ECO:0000269|PubMed:10364255}.		cognition [GO:0050890]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; transcription factor TFIIA complex [GO:0005672]	DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; transcription factor TFIIA complex [GO:0005672]; DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]; cognition [GO:0050890]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16525715}. Note=Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa.
Q9UNX9	reviewed	KCJ14_HUMAN	ATP-sensitive inward rectifier potassium channel 14 (Inward rectifier K(+) channel Kir2.4) (IRK-4) (Potassium channel, inwardly rectifying subfamily J member 14)	KCNJ14 IRK4	Homo sapiens (Human)	436	FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity). {ECO:0000250}.		potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765]	dendrite [GO:0030425]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	inward rectifier potassium channel activity [GO:0005242]	dendrite [GO:0030425]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; inward rectifier potassium channel activity [GO:0005242]; potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9UPU3	reviewed	SORC3_HUMAN	VPS10 domain-containing receptor SorCS3	SORCS3 KIAA1059	Homo sapiens (Human)	1222			learning [GO:0007612]; memory [GO:0007613]; neuropeptide signaling pathway [GO:0007218]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of long-term synaptic depression [GO:1900452]	glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; postsynaptic density membrane [GO:0098839]	neuropeptide receptor activity [GO:0008188]	glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; postsynaptic density membrane [GO:0098839]; neuropeptide receptor activity [GO:0008188]; learning [GO:0007612]; memory [GO:0007613]; neuropeptide signaling pathway [GO:0007218]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of long-term synaptic depression [GO:1900452]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q9UPX0	reviewed	TUTLB_HUMAN	Protein turtle homolog B (Immunoglobulin superfamily member 9B) (IgSF9B)	IGSF9B KIAA1030	Homo sapiens (Human)	1349	FUNCTION: Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion. {ECO:0000250|UniProtKB:D3ZB51, ECO:0000250|UniProtKB:E9PZ19}.		cell adhesion [GO:0007155]; nervous system development [GO:0007399]	neuron projection [GO:0043005]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]		neuron projection [GO:0043005]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; cell adhesion [GO:0007155]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:D3ZB51}; Single-pass type I membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000250|UniProtKB:D3ZB51}.
Q9UQ10	reviewed	DHDH_HUMAN	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase) (Hum2DD)	DHDH 2DD	Homo sapiens (Human)	334			D-xylose catabolic process [GO:0042843]		D-xylose 1-dehydrogenase (NADP+) activity [GO:0047837]; nucleotide binding [GO:0000166]; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115]	D-xylose 1-dehydrogenase (NADP+) activity [GO:0047837]; nucleotide binding [GO:0000166]; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115]; D-xylose catabolic process [GO:0042843]	
Q9UQ72	reviewed	PSG11_HUMAN	Pregnancy-specific beta-1-glycoprotein 11 (PS-beta-G-11) (PSBG-11) (Pregnancy-specific glycoprotein 11) (Pregnancy-specific beta-1-glycoprotein 13) (PS-beta-G-13) (PSBG-13) (Pregnancy-specific glycoprotein 13)	PSG11 PSG13 PSG14	Homo sapiens (Human)	335			female pregnancy [GO:0007565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]	cell surface [GO:0009986]; extracellular region [GO:0005576]		cell surface [GO:0009986]; extracellular region [GO:0005576]; female pregnancy [GO:0007565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9UQG0	reviewed	POK11_HUMAN	Endogenous retrovirus group K member 11 Pol protein (HERV-K_3q27.2 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]	ERVK-11	Homo sapiens (Human)	969	FUNCTION: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity). {ECO:0000250}.	MISCELLANEOUS: Exact N-terminus of this protein has not been formally described.; MISCELLANEOUS: The 102 C-terminal amino acids differ from HERV-K(HML-2) Pol prototype due to a frameshift in position 867.	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]		DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]	DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; zinc ion binding [GO:0008270]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]	
Q9Y2A4	reviewed	ZN443_HUMAN	Zinc finger protein 443 (Krueppel-type zinc finger protein ZK1)	ZNF443	Homo sapiens (Human)	671	FUNCTION: May be involved in transcriptional regulation.		apoptotic process [GO:0006915]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; apoptotic process [GO:0006915]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y2B2	reviewed	PIGL_HUMAN	N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) (Phosphatidylinositol-glycan biosynthesis class L protein) (PIG-L)	PIGL	Homo sapiens (Human)	252	FUNCTION: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.		GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]	endoplasmic reticulum membrane [GO:0005789]	N-acetylglucosaminylphosphatidylinositol deacetylase activity [GO:0000225]	endoplasmic reticulum membrane [GO:0005789]; N-acetylglucosaminylphosphatidylinositol deacetylase activity [GO:0000225]; GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q9Y2C2	reviewed	UST_HUMAN	Uronyl 2-sulfotransferase (EC 2.8.2.-)	UST DS2ST	Homo sapiens (Human)	406	FUNCTION: Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.		dermatan sulfate biosynthetic process [GO:0030208]; establishment of cell polarity [GO:0030010]; protein sulfation [GO:0006477]; regulation of axonogenesis [GO:0050770]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; sulfotransferase activity [GO:0008146]; dermatan sulfate biosynthetic process [GO:0030208]; establishment of cell polarity [GO:0030010]; protein sulfation [GO:0006477]; regulation of axonogenesis [GO:0050770]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q9Y2D9	reviewed	ZN652_HUMAN	Zinc finger protein 652	ZNF652 KIAA0924	Homo sapiens (Human)	606	FUNCTION: Functions as a transcriptional repressor. {ECO:0000269|PubMed:16966434}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y2G4	reviewed	ANKR6_HUMAN	Ankyrin repeat domain-containing protein 6 (Diversin)	ANKRD6 KIAA0957	Homo sapiens (Human)	727	FUNCTION: Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. {ECO:0000250}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of JNK cascade [GO:0046330]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of JNK cascade [GO:0046330]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]	
Q9Y2H8	reviewed	ZN510_HUMAN	Zinc finger protein 510	ZNF510 KIAA0972	Homo sapiens (Human)	683	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y2L6	reviewed	FRM4B_HUMAN	FERM domain-containing protein 4B (GRP1-binding protein GRSP1)	FRMD4B GRSP1 KIAA1013	Homo sapiens (Human)	1034	FUNCTION: Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}.		establishment of epithelial cell polarity [GO:0090162]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; ruffle [GO:0001726]		adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; ruffle [GO:0001726]; establishment of epithelial cell polarity [GO:0090162]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q920B0}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q920B0}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q920B0}. Note=Colocalized with PARD3 at adherens junction and tight junction. {ECO:0000250|UniProtKB:Q920B0}.
Q9Y2L8	reviewed	ZKSC5_HUMAN	Zinc finger protein with KRAB and SCAN domains 5 (Zinc finger protein 95 homolog) (Zfp-95)	ZKSCAN5 KIAA1015 ZFP95	Homo sapiens (Human)	839	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q9Y2Q1	reviewed	ZN257_HUMAN	Zinc finger protein 257 (Bone marrow zinc finger 4) (BMZF-4)	ZNF257 BMZF4	Homo sapiens (Human)	563	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y2Q9	reviewed	RT28_HUMAN	Small ribosomal subunit protein bS1m (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt)	MRPS28 MRPS35 HSPC007	Homo sapiens (Human)	187			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
Q9Y2R5	reviewed	RT17_HUMAN	Small ribosomal subunit protein uS17m (28S ribosomal protein S17, mitochondrial) (MRP-S17) (S17mt)	MRPS17 RPMS17 HSPC011	Homo sapiens (Human)	130			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]	rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
Q9Y2R9	reviewed	RT07_HUMAN	Small ribosomal subunit protein uS7m (28S ribosomal protein S7, mitochondrial) (MRP-S7) (S7mt) (bMRP-27a) (bMRP27a)	MRPS7	Homo sapiens (Human)	242			mitochondrial translation [GO:0032543]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; ribosome [GO:0005840]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; ribosome [GO:0005840]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
Q9Y2T4	reviewed	2ABG_HUMAN	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (IMYPNO1) (PP2A subunit B isoform B55-gamma) (PP2A subunit B isoform PR55-gamma) (PP2A subunit B isoform R2-gamma) (PP2A subunit B isoform gamma)	PPP2R2C	Homo sapiens (Human)	447	FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.			cytosol [GO:0005829]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase regulator activity [GO:0019888]	cytosol [GO:0005829]; protein phosphatase type 2A complex [GO:0000159]; protein phosphatase regulator activity [GO:0019888]	
Q9Y2T5	reviewed	GPR52_HUMAN	G-protein coupled receptor 52	GPR52	Homo sapiens (Human)	361	FUNCTION: Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). {ECO:0000269|PubMed:24587241, ECO:0000269|PubMed:25738228}.		cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; locomotory behavior [GO:0007626]; phototransduction [GO:0007602]; response to xenobiotic stimulus [GO:0009410]	plasma membrane [GO:0005886]	G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; locomotory behavior [GO:0007626]; phototransduction [GO:0007602]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9Y2U2	reviewed	KCNK7_HUMAN	Potassium channel subfamily K member 7	KCNK7	Homo sapiens (Human)	307	FUNCTION: Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.		potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; stabilization of membrane potential [GO:0030322]	plasma membrane [GO:0005886]	outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9Y305	reviewed	ACOT9_HUMAN	Acyl-coenzyme A thioesterase 9, mitochondrial (Acyl-CoA thioesterase 9) (EC 3.1.2.-) (Acyl-CoA thioester hydrolase 9)	ACOT9 CGI-16	Homo sapiens (Human)	439	FUNCTION: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs.		acyl-CoA metabolic process [GO:0006637]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	acetyl-CoA hydrolase activity [GO:0003986]; acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; palmitoyl-CoA hydrolase activity [GO:0016290]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; acetyl-CoA hydrolase activity [GO:0003986]; acyl-CoA hydrolase activity [GO:0047617]; carboxylic ester hydrolase activity [GO:0052689]; palmitoyl-CoA hydrolase activity [GO:0016290]; acyl-CoA metabolic process [GO:0006637]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
Q9Y330	reviewed	ZBT12_HUMAN	Zinc finger and BTB domain-containing protein 12 (Protein G10)	ZBTB12 C6orf46 G10 NG35	Homo sapiens (Human)	459	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	nucleoplasm [GO:0005654]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleoplasm [GO:0005654]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y334	reviewed	VWA7_HUMAN	von Willebrand factor A domain-containing protein 7 (Protein G7c)	VWA7 C6orf27 G7C NG37	Homo sapiens (Human)	891		MISCELLANEOUS: Found in the major hispocompatibility complex class III region. May be implicated in susceptibility to lung tumors.		extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9Y3B6	reviewed	EMC9_HUMAN	ER membrane protein complex subunit 9 (Protein FAM158A)	EMC9 C14orf122 FAM158A CGI-112	Homo sapiens (Human)	208	FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32459176, ECO:0000305}.		protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	cytoplasm [GO:0005737]; EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]		cytoplasm [GO:0005737]; EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:32459176}; Peripheral membrane protein {ECO:0000305|PubMed:32459176}; Cytoplasmic side {ECO:0000269|PubMed:22119785}.
Q9Y3C1	reviewed	NOP16_HUMAN	Nucleolar protein 16 (HBV pre-S2 trans-regulated protein 3)	NOP16 CGI-117 HSPC111	Homo sapiens (Human)	178			ribosomal large subunit biogenesis [GO:0042273]	intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; ribosomal large subunit biogenesis [GO:0042273]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Q9Y3X0	reviewed	CCDC9_HUMAN	Coiled-coil domain-containing protein 9	CCDC9	Homo sapiens (Human)	531	FUNCTION: Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. {ECO:0000305|PubMed:33973408}.			exon-exon junction complex [GO:0035145]	RNA binding [GO:0003723]	exon-exon junction complex [GO:0035145]; RNA binding [GO:0003723]	
Q9Y421	reviewed	FA32A_HUMAN	Protein FAM32A (Ovarian tumor-associated gene 12) (OTAG-12)	FAM32A OTAG12 CGI-144	Homo sapiens (Human)	112	FUNCTION: Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. {ECO:0000269|PubMed:21339736}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]	SUBCELLULAR LOCATION: [Isoform 1]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
Q9Y471	reviewed	CMAH_HUMAN	Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-NeuAc hydroxylase-like protein) (Cytidine monophosphate-N-acetylneuraminic acid hydroxylase pseudogene)	CMAHP CMAH	Homo sapiens (Human)	501	FUNCTION: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. That protein has no CMP-N-acetylneuraminate monooxygenase activity and is not able to convert CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells in vertebrates (PubMed:9624188). However, it may play a role in Wnt signaling (PubMed:19890979). {ECO:0000269|PubMed:19890979, ECO:0000269|PubMed:9624188, ECO:0000303|PubMed:11562455, ECO:0000303|PubMed:12192086, ECO:0000303|PubMed:9751737}.		CMP-N-acetylneuraminate metabolic process [GO:0046381]; regulation of Wnt signaling pathway [GO:0030111]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; nucleus [GO:0005634]	CMP-N-acetylneuraminate monooxygenase activity [GO:0030338]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; nucleus [GO:0005634]; CMP-N-acetylneuraminate monooxygenase activity [GO:0030338]; CMP-N-acetylneuraminate metabolic process [GO:0046381]; regulation of Wnt signaling pathway [GO:0030111]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19890979}. Note=May localize to membranes, nucleus and cytoskeleton. {ECO:0000269|PubMed:19890979}.
Q9Y4F5	reviewed	C170B_HUMAN	Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B)	CEP170B FAM68C KIAA0284	Homo sapiens (Human)	1589	FUNCTION: Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.			cytoplasm [GO:0005737]; microtubule [GO:0005874]		cytoplasm [GO:0005737]; microtubule [GO:0005874]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q498L0}.
Q9Y4I5	reviewed	MTL5_HUMAN	Tesmin (Metallothionein-like 5, testis-specific) (Testis-specific metallothionein-like protein)	TESMIN MTL5	Homo sapiens (Human)	508	FUNCTION: Essential for normal spermatogenesis and male fertility (By similarity). Required for the completion of meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:Q9WTJ6}.		cell differentiation [GO:0030154]; intracellular monoatomic cation homeostasis [GO:0030003]; male meiotic nuclear division [GO:0007140]; regulation of DNA-templated transcription [GO:0006355]; response to metal ion [GO:0010038]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; cell differentiation [GO:0030154]; intracellular monoatomic cation homeostasis [GO:0030003]; male meiotic nuclear division [GO:0007140]; regulation of DNA-templated transcription [GO:0006355]; response to metal ion [GO:0010038]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9WTJ6}. Nucleus {ECO:0000250|UniProtKB:Q9WTJ6}. Note=Predominantly localized to the cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc. {ECO:0000250|UniProtKB:Q9WTJ6}.
Q9Y4K1	reviewed	CRBG1_HUMAN	Beta/gamma crystallin domain-containing protein 1 (Absent in melanoma 1 protein)	CRYBG1 AIM1	Homo sapiens (Human)	1723	FUNCTION: May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.				carbohydrate binding [GO:0030246]	carbohydrate binding [GO:0030246]	
Q9Y4P3	reviewed	TBL2_HUMAN	Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein)	TBL2 WBSCR13 UNQ563/PRO1125	Homo sapiens (Human)	447			cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; endoplasmic reticulum unfolded protein response [GO:0030968]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	phosphoprotein binding [GO:0051219]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; translation initiation factor binding [GO:0031369]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; phosphoprotein binding [GO:0051219]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; translation initiation factor binding [GO:0031369]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; endoplasmic reticulum unfolded protein response [GO:0030968]	
Q9Y543	reviewed	HES2_HUMAN	Transcription factor HES-2 (Class B basic helix-loop-helix protein 40) (bHLHb40) (Hairy and enhancer of split 2)	HES2 BHLHB40	Homo sapiens (Human)	173	FUNCTION: Transcriptional repressor of genes that require a bHLH protein for their transcription. {ECO:0000250}.		anterior/posterior pattern specification [GO:0009952]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; anterior/posterior pattern specification [GO:0009952]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Q9Y573	reviewed	IPP_HUMAN	Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Kelch-like protein 27)	IPP KLHL27	Homo sapiens (Human)	584	FUNCTION: May play a role in organizing the actin cytoskeleton.			actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]	actin binding [GO:0003779]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; actin binding [GO:0003779]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
Q9Y585	reviewed	OR1A2_HUMAN	Olfactory receptor 1A2 (Olfactory receptor 17-6) (OR17-6) (Olfactory receptor OR17-10)	OR1A2	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		positive regulation of cytokinesis [GO:0032467]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; positive regulation of cytokinesis [GO:0032467]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9Y597	reviewed	KCTD3_HUMAN	BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45)	KCTD3	Homo sapiens (Human)	815	FUNCTION: Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}.	MISCELLANEOUS: Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors. Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens.	protein homooligomerization [GO:0051260]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; protein homooligomerization [GO:0051260]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BFX3}.
Q9Y5E1	reviewed	PCDB9_HUMAN	Protocadherin beta-9 (PCDH-beta-9) (Protocadherin-3H)	PCDHB9 PCDH3H	Homo sapiens (Human)	797	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5E2	reviewed	PCDB7_HUMAN	Protocadherin beta-7 (PCDH-beta-7)	PCDHB7	Homo sapiens (Human)	793	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5E4	reviewed	PCDB5_HUMAN	Protocadherin beta-5 (PCDH-beta-5)	PCDHB5	Homo sapiens (Human)	795	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5E5	reviewed	PCDB4_HUMAN	Protocadherin beta-4 (PCDH-beta-4)	PCDHB4	Homo sapiens (Human)	795	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5E6	reviewed	PCDB3_HUMAN	Protocadherin beta-3 (PCDH-beta-3)	PCDHB3	Homo sapiens (Human)	796	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5E7	reviewed	PCDB2_HUMAN	Protocadherin beta-2 (PCDH-beta-2)	PCDHB2	Homo sapiens (Human)	798	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5E8	reviewed	PCDBF_HUMAN	Protocadherin beta-15 (PCDH-beta-15)	PCDHB15	Homo sapiens (Human)	787	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5F0	reviewed	PCDBD_HUMAN	Protocadherin beta-13 (PCDH-beta-13)	PCDHB13 UNQ332/PRO531	Homo sapiens (Human)	798	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]	membrane [GO:0016020]; photoreceptor connecting cilium [GO:0032391]; photoreceptor disc membrane [GO:0097381]; postsynaptic membrane [GO:0045211]	calcium ion binding [GO:0005509]	membrane [GO:0016020]; photoreceptor connecting cilium [GO:0032391]; photoreceptor disc membrane [GO:0097381]; postsynaptic membrane [GO:0045211]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5F3	reviewed	PCDB1_HUMAN	Protocadherin beta-1 (PCDH-beta-1)	PCDHB1	Homo sapiens (Human)	818	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5F6	reviewed	PCDGM_HUMAN	Protocadherin gamma-C5 (PCDH-gamma-C5)	PCDHGC5	Homo sapiens (Human)	944	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; synapse organization [GO:0050808]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5F8	reviewed	PCDGJ_HUMAN	Protocadherin gamma-B7 (PCDH-gamma-B7)	PCDHGB7	Homo sapiens (Human)	929	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5F9	reviewed	PCDGI_HUMAN	Protocadherin gamma-B6 (PCDH-gamma-B6)	PCDHGB6	Homo sapiens (Human)	930	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5G0	reviewed	PCDGH_HUMAN	Protocadherin gamma-B5 (PCDH-gamma-B5)	PCDHGB5	Homo sapiens (Human)	923	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5G1	reviewed	PCDGF_HUMAN	Protocadherin gamma-B3 (PCDH-gamma-B3)	PCDHGB3	Homo sapiens (Human)	929	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5G2	reviewed	PCDGE_HUMAN	Protocadherin gamma-B2 (PCDH-gamma-B2)	PCDHGB2	Homo sapiens (Human)	931	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5G3	reviewed	PCDGD_HUMAN	Protocadherin gamma-B1 (PCDH-gamma-B1)	PCDHGB1	Homo sapiens (Human)	927	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	growth cone [GO:0030426]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	growth cone [GO:0030426]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5G4	reviewed	PCDG9_HUMAN	Protocadherin gamma-A9 (PCDH-gamma-A9)	PCDHGA9	Homo sapiens (Human)	932	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; RNA binding [GO:0003723]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; RNA binding [GO:0003723]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5G5	reviewed	PCDG8_HUMAN	Protocadherin gamma-A8 (PCDH-gamma-A8)	PCDHGA8 KIAA0327	Homo sapiens (Human)	932	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5G6	reviewed	PCDG7_HUMAN	Protocadherin gamma-A7 (PCDH-gamma-A7)	PCDHGA7	Homo sapiens (Human)	932	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5G7	reviewed	PCDG6_HUMAN	Protocadherin gamma-A6 (PCDH-gamma-A6)	PCDHGA6	Homo sapiens (Human)	932	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5G8	reviewed	PCDG5_HUMAN	Protocadherin gamma-A5 (PCDH-gamma-A5)	PCDHGA5	Homo sapiens (Human)	931	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5G9	reviewed	PCDG4_HUMAN	Protocadherin gamma-A4 (PCDH-gamma-A4)	PCDHGA4	Homo sapiens (Human)	962	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5H0	reviewed	PCDG3_HUMAN	Protocadherin gamma-A3 (PCDH-gamma-A3)	PCDHGA3	Homo sapiens (Human)	932	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; endosome to lysosome transport [GO:0008333]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lipid tube assembly involved in organelle fusion [GO:0060989]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; endosome to lysosome transport [GO:0008333]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lipid tube assembly involved in organelle fusion [GO:0060989]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5H1	reviewed	PCDG2_HUMAN	Protocadherin gamma-A2 (PCDH-gamma-A2)	PCDHGA2	Homo sapiens (Human)	932	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5H2	reviewed	PCDGB_HUMAN	Protocadherin gamma-A11 (PCDH-gamma-A11)	PCDHGA11	Homo sapiens (Human)	935	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5H3	reviewed	PCDGA_HUMAN	Protocadherin gamma-A10 (PCDH-gamma-A10)	PCDHGA10	Homo sapiens (Human)	936	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5H4	reviewed	PCDG1_HUMAN	Protocadherin gamma-A1 (PCDH-gamma-A1)	PCDHGA1	Homo sapiens (Human)	931	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5H6	reviewed	PCDA8_HUMAN	Protocadherin alpha-8 (PCDH-alpha-8)	PCDHA8	Homo sapiens (Human)	950	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5H7	reviewed	PCDA5_HUMAN	Protocadherin alpha-5 (PCDH-alpha-5)	PCDHA5 CNRS6	Homo sapiens (Human)	936	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5I0	reviewed	PCDAD_HUMAN	Protocadherin alpha-13 (PCDH-alpha-13)	PCDHA13 CNRS5	Homo sapiens (Human)	950	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5I1	reviewed	PCDAB_HUMAN	Protocadherin alpha-11 (PCDH-alpha-11)	PCDHA11 CNRS7	Homo sapiens (Human)	949	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5I4	reviewed	PCDC2_HUMAN	Protocadherin alpha-C2 (PCDH-alpha-C2)	PCDHAC2	Homo sapiens (Human)	1007	FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; serotonergic neuron axon guidance [GO:0036515]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; serotonergic neuron axon guidance [GO:0036515]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q9Y5J9	reviewed	TIM8B_HUMAN	Mitochondrial import inner membrane translocase subunit Tim8 B (DDP-like protein) (Deafness dystonia protein 2)	TIMM8B DDP2 DDPL TIM8B	Homo sapiens (Human)	83	FUNCTION: Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). {ECO:0000250}.		protein insertion into mitochondrial inner membrane [GO:0045039]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605]	extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]	protein transporter activity [GO:0140318]; zinc ion binding [GO:0008270]	extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; protein transporter activity [GO:0140318]; zinc ion binding [GO:0008270]; protein insertion into mitochondrial inner membrane [GO:0045039]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Intermembrane side {ECO:0000250}.
Q9Y5M8	reviewed	SRPRB_HUMAN	Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1)	SRPRB PSEC0230	Homo sapiens (Human)	271	FUNCTION: Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May mediate the membrane association of SR (By similarity). {ECO:0000250|UniProtKB:P47758}.		protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; signal recognition particle receptor complex [GO:0005785]	GTP binding [GO:0005525]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; signal recognition particle receptor complex [GO:0005785]; GTP binding [GO:0005525]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O13950}; Single-pass membrane protein {ECO:0000255}.
Q9Y5P1	reviewed	O51B2_HUMAN	Olfactory receptor 51B2 (Odorant receptor HOR5'beta3) (Olfactory receptor 51B1)	OR51B2 OR51B1P	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9Y5P3	reviewed	RAI2_HUMAN	Retinoic acid-induced protein 2	RAI2	Homo sapiens (Human)	530			animal organ development [GO:0048513]; embryo development ending in birth or egg hatching [GO:0009792]	nucleus [GO:0005634]		nucleus [GO:0005634]; animal organ development [GO:0048513]; embryo development ending in birth or egg hatching [GO:0009792]	
Q9Y5Y3	reviewed	GPR45_HUMAN	Probable G-protein coupled receptor 45 (PSP24-1) (PSP24-alpha)	GPR45	Homo sapiens (Human)	372	FUNCTION: Orphan receptor. May play a role in brain function.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9Y644	reviewed	RFNG_HUMAN	Beta-1,3-N-acetylglucosaminyltransferase radical fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)	RFNG	Homo sapiens (Human)	331	FUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis. {ECO:0000250|UniProtKB:O09009, ECO:0000250|UniProtKB:O12972, ECO:0000250|UniProtKB:Q9R1U9}.		animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; pattern specification process [GO:0007389]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of Notch signaling pathway [GO:0008593]	extracellular region [GO:0005576]; Golgi membrane [GO:0000139]	metal ion binding [GO:0046872]; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity [GO:0033829]	extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; metal ion binding [GO:0046872]; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity [GO:0033829]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; pattern specification process [GO:0007389]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of Notch signaling pathway [GO:0008593]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9Y661	reviewed	HS3S4_HUMAN	Heparan sulfate glucosamine 3-O-sulfotransferase 4 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4) (3-OST-4) (Heparan sulfate 3-O-sulfotransferase 4) (h3-OST-4)	HS3ST4 3OST4	Homo sapiens (Human)	456	FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). {ECO:0000250}.		heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan metabolic process [GO:0030201]	Golgi membrane [GO:0000139]	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]	Golgi membrane [GO:0000139]; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan metabolic process [GO:0030201]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9Y689	reviewed	ARL5A_HUMAN	ADP-ribosylation factor-like protein 5A	ARL5A ARFLP5 ARL5	Homo sapiens (Human)	179	FUNCTION: Lacks ADP-ribosylation enhancing activity. {ECO:0000250}.		intracellular protein transport [GO:0006886]; protein localization to Golgi membrane [GO:1903292]; vesicle-mediated transport [GO:0016192]	trans-Golgi network [GO:0005802]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	trans-Golgi network [GO:0005802]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; protein localization to Golgi membrane [GO:1903292]; vesicle-mediated transport [GO:0016192]	
Q9Y6I0	reviewed	VPK6_HUMAN	Endogenous retrovirus group K member 6 Pro protein (HERV-K(C7) Pro protein) (HERV-K(HML-2.HOM) Pro protein) (HERV-K108 Pro protein) (HERV-K_7p22.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)	ERVK-6 ERVK6	Homo sapiens (Human)	156	FUNCTION: Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: Two human-specific proviruses are inserted as tandem repeats with a shared LTR in most individuals tested. The telomeric copy is referred here as 'provirus 41574'. The centromeric copy is referred here as 'provirus 41575'.	proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; proteolysis [GO:0006508]	
Q9Y6I8	reviewed	PXMP4_HUMAN	Peroxisomal membrane protein 4 (24 kDa peroxisomal intrinsic membrane protein)	PXMP4 PMP24	Homo sapiens (Human)	212		MISCELLANEOUS: Hypermethylation-mediated silencing of PXMP4 may be involved in prostate carcinogenesis. PXMP4 undergoes hypermethylation and silencing during the transition of prostate adenocarcinoma cells from androgen dependence to androgen independence.	ether lipid metabolic process [GO:0046485]	cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]		cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; ether lipid metabolic process [GO:0046485]	SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9Y6N3	reviewed	CLCA3_HUMAN	Calcium-activated chloride channel regulator family member 3 (Calcium-activated chloride channel family member 3) (hCLCA3)	CLCA3P CLCA3	Homo sapiens (Human)	262			monoatomic ion transmembrane transport [GO:0034220]; regulation of monoatomic ion transmembrane transport [GO:0034765]	chloride channel complex [GO:0034707]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]	calcium channel activity [GO:0005262]; chloride channel activity [GO:0005254]; metalloendopeptidase activity [GO:0004222]; voltage-gated monoatomic ion channel activity [GO:0005244]	chloride channel complex [GO:0034707]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; chloride channel activity [GO:0005254]; metalloendopeptidase activity [GO:0004222]; voltage-gated monoatomic ion channel activity [GO:0005244]; monoatomic ion transmembrane transport [GO:0034220]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10095065}.
Q9Y6Q3	reviewed	ZFP37_HUMAN	Zinc finger protein 37 homolog (Zfp-37)	ZFP37	Homo sapiens (Human)	630	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y6S9	reviewed	RPKL1_HUMAN	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1)	RPS6KL1	Homo sapiens (Human)	549			phosphorylation [GO:0016310]	ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	
Q9Y6V7	reviewed	DDX49_HUMAN	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.4.13) (DEAD box protein 49)	DDX49	Homo sapiens (Human)	483			positive regulation of cell growth [GO:0030307]; regulation of rRNA stability [GO:0044357]; rRNA processing [GO:0006364]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; positive regulation of cell growth [GO:0030307]; regulation of rRNA stability [GO:0044357]; rRNA processing [GO:0006364]	
Q9YNA8	reviewed	GAK19_HUMAN	Endogenous retrovirus group K member 19 Gag polyprotein (HERV-K(C19) Gag protein) (HERV-K_19q11 provirus ancestral Gag polyprotein) (Gag polyprotein)	ERVK-19	Homo sapiens (Human)	666	FUNCTION: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.		viral process [GO:0016032]	plasma membrane [GO:0005886]	nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]; nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.
U3KPV4	reviewed	A3LT2_HUMAN	Alpha-1,3-galactosyltransferase 2 (EC 2.4.1.87) (Isoglobotriaosylceramide synthase) (iGb3 synthase) (iGb3S)	A3GALT2 A3GALT2P IGBS3S	Homo sapiens (Human)	340	FUNCTION: Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. {ECO:0000305|PubMed:23378701}.		carbohydrate metabolic process [GO:0005975]; glycosphingolipid biosynthetic process [GO:0006688]; lipid glycosylation [GO:0030259]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; vesicle [GO:0031982]	glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872]; N-acetyllactosaminide 3-alpha-galactosyltransferase activity [GO:0047276]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; vesicle [GO:0031982]; glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872]; N-acetyllactosaminide 3-alpha-galactosyltransferase activity [GO:0047276]; carbohydrate metabolic process [GO:0005975]; glycosphingolipid biosynthetic process [GO:0006688]; lipid glycosylation [GO:0030259]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:A0A4Z3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:A0A4Z3}. Note=Also found in numerous large vesicles throughout the cytoplasm of the soma. {ECO:0000250|UniProtKB:A0A4Z3}.
W5XKT8	reviewed	SACA6_HUMAN	Sperm acrosome membrane-associated protein 6 (BACHELOR-like protein)	SPACA6 SPACA6P UNQ2487/PRO5774	Homo sapiens (Human)	324	FUNCTION: Sperm protein required for fusion of sperm with the egg membrane during fertilization. {ECO:0000250|UniProtKB:E9Q8Q8}.	MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: Due to intron retention. {ECO:0000305}.	fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	acrosomal membrane [GO:0002080]		acrosomal membrane [GO:0002080]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:32210282}; Single-pass type I membrane protein {ECO:0000255}.
W6CW81	reviewed	PYDC5_HUMAN	Pyrin domain-containing protein 5 (Pyrin domain-only protein 3)	PYDC5 POP3	Homo sapiens (Human)	113	FUNCTION: Functions as an inhibitor of DNA virus-induced activation of AIM2-like receptors (ALR) inflammasome through interaction with AIM2. {ECO:0000269|PubMed:24531343}.		cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; inflammatory response [GO:0006954]; negative regulation of AIM2 inflammasome complex assembly [GO:0140972]; negative regulation of protein-containing complex assembly [GO:0031333]			cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; inflammatory response [GO:0006954]; negative regulation of AIM2 inflammasome complex assembly [GO:0140972]; negative regulation of protein-containing complex assembly [GO:0031333]	
A0A075B6H7	reviewed	KV37_HUMAN	Probable non-functional immunoglobulin kappa variable 3-7	IGKV3-7	Homo sapiens (Human)	116	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6H8	reviewed	KVD42_HUMAN	Probable non-functional immunoglobulin kappa variable 1D-42	IGKV1D-42	Homo sapiens (Human)	117	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6H9	reviewed	LV469_HUMAN	Immunoglobulin lambda variable 4-69	IGLV4-69	Homo sapiens (Human)	119	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6I0	reviewed	LV861_HUMAN	Immunoglobulin lambda variable 8-61	IGLV8-61	Homo sapiens (Human)	122	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6I1	reviewed	LV460_HUMAN	Immunoglobulin lambda variable 4-60	IGLV4-60	Homo sapiens (Human)	120	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6I3	reviewed	LVK55_HUMAN	Probable non-functional immunoglobulin lambda variable 11-55	IGLV11-55	Homo sapiens (Human)	123	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6I4	reviewed	LVX54_HUMAN	Immunoglobulin lambda variable 10-54	IGLV10-54	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6I6	reviewed	LV150_HUMAN	Probable non-functional immunoglobulin lambda variable 1-50	IGLV1-50	Homo sapiens (Human)	118	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6I7	reviewed	LV548_HUMAN	Probable non-functional immunoglobulin lambda variable 5-48	IGLV5-48	Homo sapiens (Human)	105	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6I9	reviewed	LV746_HUMAN	Immunoglobulin lambda variable 7-46	IGLV7-46	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6J1	reviewed	LV537_HUMAN	Immunoglobulin lambda variable 5-37	IGLV5-37	Homo sapiens (Human)	123	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6J2	reviewed	LV233_HUMAN	Probable non-functional immunoglobulin lambda variable 2-33	IGLV2-33	Homo sapiens (Human)	118	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6J6	reviewed	LV322_HUMAN	Immunoglobulin lambda variable 3-22	IGLV3-22	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6J9	reviewed	LV218_HUMAN	Immunoglobulin lambda variable 2-18	IGLV2-18	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6K0	reviewed	LV316_HUMAN	Immunoglobulin lambda variable 3-16	IGLV3-16	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6K2	reviewed	LV312_HUMAN	Immunoglobulin lambda variable 3-12	IGLV3-12	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6K4	reviewed	LV310_HUMAN	Immunoglobulin lambda variable 3-10	IGLV3-10	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6K5	reviewed	LV39_HUMAN	Immunoglobulin lambda variable 3-9	IGLV3-9	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6K6	reviewed	LV403_HUMAN	Immunoglobulin lambda variable 4-3	IGLV4-3	Homo sapiens (Human)	122	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6L2	reviewed	TVG11_HUMAN	Probable non-functional T cell receptor gamma variable 11	TRGV11	Homo sapiens (Human)	119	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) gamma chain (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0A075B6L6	reviewed	TVB73_HUMAN	Probable non-functional T cell receptor beta variable 7-3	TRBV7-3	Homo sapiens (Human)	115	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000269|PubMed:9619395, ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B6N2	reviewed	TVBT1_HUMAN	T cell receptor beta variable 20-1	TRBV20-1	Homo sapiens (Human)	111	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B6N3	reviewed	TVBX1_HUMAN	T cell receptor beta variable 24-1	TRBV24-1	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B6N4	reviewed	TVBY1_HUMAN	T cell receptor beta variable 25-1	TRBV25-1	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B6P5	reviewed	KV228_HUMAN	Immunoglobulin kappa variable 2-28	IGKV2-28	Homo sapiens (Human)	120	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6Q5	reviewed	HV364_HUMAN	Immunoglobulin heavy variable 3-64	IGHV3-64	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6R0	reviewed	TRGV2_HUMAN	T cell receptor gamma variable 2	TRGV2 TCRGV2	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]; innate immune response [GO:0045087]	external side of plasma membrane [GO:0009897]; T cell receptor complex [GO:0042101]		external side of plasma membrane [GO:0009897]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0A075B6R2	reviewed	HV404_HUMAN	Immunoglobulin heavy variable 4-4	IGHV4-4	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6R9	reviewed	KVD24_HUMAN	Probable non-functional immunoglobulin kappa variable 2D-24	IGKV2D-24	Homo sapiens (Human)	120	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6S2	reviewed	KVD29_HUMAN	Immunoglobulin kappa variable 2D-29	IGKV2D-29	Homo sapiens (Human)	120	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6S4	reviewed	KVD17_HUMAN	Immunoglobulin kappa variable 1D-17	IGKV1D-17	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6S5	reviewed	KV127_HUMAN	Immunoglobulin kappa variable 1-27	IGKV1-27	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6S6	reviewed	KVD30_HUMAN	Immunoglobulin kappa variable 2D-30	IGKV2D-30	Homo sapiens (Human)	120	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6S9	reviewed	KV137_HUMAN	Probable non-functional immunoglobulinn kappa variable 1-37	IGKV1-37	Homo sapiens (Human)	117	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A075B6T6	reviewed	TVAL2_HUMAN	T cell receptor alpha variable 12-2	TRAV12-2	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]	peptide antigen binding [GO:0042605]	T cell receptor complex [GO:0042101]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B6T7	reviewed	TVA6_HUMAN	T cell receptor alpha variable 6	TRAV6 TCRAV5S1	Homo sapiens (Human)	132	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B6T8	reviewed	TVA91_HUMAN	T cell receptor alpha variable 9-1	TRAV9-1	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B6U4	reviewed	TVA7_HUMAN	T cell receptor alpha variable 7	TRAV7	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B6V5	reviewed	TVA36_HUMAN	T cell receptor alpha variable 36/delta variable 7	TRAV36DV7	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B6W5	reviewed	TVA23_HUMAN	T cell receptor alpha variable 23/delta variable 6	TRAV23DV6	Homo sapiens (Human)	121	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]	peptide antigen binding [GO:0042605]	T cell receptor complex [GO:0042101]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B6X5	reviewed	TVA18_HUMAN	T cell receptor alpha variable 18	TRAV18	Homo sapiens (Human)	111	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B767	reviewed	PAL4H_HUMAN	Peptidyl-prolyl cis-trans isomerase A-like 4H (PPIase A-like 4H) (EC 5.2.1.8)	PPIAL4H	Homo sapiens (Human)	164	FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000250|UniProtKB:P62937}.	MISCELLANEOUS: It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1. {ECO:0000305}.	protein folding [GO:0006457]	cytoplasm [GO:0005737]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62937}.
A0A087WSX0	reviewed	LV545_HUMAN	Immunoglobulin lambda variable 5-45	IGLV5-45	Homo sapiens (Human)	123	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A087WSY4	reviewed	HV432_HUMAN	Immunoglobulin heavy variable 4-30-2	IGHV4-30-2	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A087WSY6	reviewed	KVD15_HUMAN	Immunoglobulin kappa variable 3D-15	IGKV3D-15	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A087WSZ0	reviewed	KVD08_HUMAN	Immunoglobulin kappa variable 1D-8	IGKV1D-8	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A087WSZ9	reviewed	TVA30_HUMAN	T cell receptor alpha variable 30	TRAV30	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A087WT02	reviewed	TVA92_HUMAN	T cell receptor alpha variable 9-2	TRAV9-2	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A087WT03	reviewed	TVAZ1_HUMAN	T cell receptor alpha variable 26-1	TRAV26-1	Homo sapiens (Human)	109	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A087WV62	reviewed	TVB16_HUMAN	T cell receptor beta variable 16	TRBV16	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A087WVF3	reviewed	TBC3D_HUMAN	TBC1 domain family member 3D	TBC1D3D	Homo sapiens (Human)	549	FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250|UniProtKB:Q8IZP1}.	MISCELLANEOUS: TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor. {ECO:0000305}.		plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IZP1}; Lipid-anchor {ECO:0000250|UniProtKB:Q8IZP1}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:Q8IZP1}.
A0A087WW87	reviewed	KV240_HUMAN	Immunoglobulin kappa variable 2-40	IGKV2-40	Homo sapiens (Human)	121	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A087WXM9	reviewed	MEIKN_HUMAN	Meiosis-specific kinetochore protein	MEIKIN	Homo sapiens (Human)	373	FUNCTION: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis. {ECO:0000250|UniProtKB:Q5F2C3}.		female meiosis chromosome segregation [GO:0016321]; homologous chromosome segregation [GO:0045143]; male meiosis chromosome segregation [GO:0007060]; meiotic sister chromatid cohesion involved in meiosis I [GO:0010789]; meiotic sister chromatid cohesion, centromeric [GO:0051754]	condensed chromosome, centromeric region [GO:0000779]; kinetochore [GO:0000776]		condensed chromosome, centromeric region [GO:0000779]; kinetochore [GO:0000776]; female meiosis chromosome segregation [GO:0016321]; homologous chromosome segregation [GO:0045143]; male meiosis chromosome segregation [GO:0007060]; meiotic sister chromatid cohesion involved in meiosis I [GO:0010789]; meiotic sister chromatid cohesion, centromeric [GO:0051754]	SUBCELLULAR LOCATION: Chromosome, centromere {ECO:0000250|UniProtKB:Q5F2C3}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q5F2C3}. Note=Localizes at kinetochores in meiosis I but undetectable in meiosis II. {ECO:0000250|UniProtKB:Q5F2C3}.
A0A087X0K7	reviewed	TVB17_HUMAN	Probable non-functional T cell receptor beta variable 17	TRBV17	Homo sapiens (Human)	114	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000269|PubMed:9619395, ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A087X0M5	reviewed	TVB18_HUMAN	T cell receptor beta variable 18	TRBV18	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A087X179	reviewed	TBC3E_HUMAN	TBC1 domain family member 3E	TBC1D3E	Homo sapiens (Human)	549	FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250|UniProtKB:Q8IZP1}.	MISCELLANEOUS: TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor. {ECO:0000305}.		plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IZP1}; Lipid-anchor {ECO:0000250|UniProtKB:Q8IZP1}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:Q8IZP1}.
A0A096LP55	reviewed	QCR6L_HUMAN	Cytochrome b-c1 complex subunit 6-like, mitochondrial	UQCRHL	Homo sapiens (Human)	91	FUNCTION: May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. {ECO:0000250|UniProtKB:P00127}.		mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	mitochondrial respiratory chain complex III [GO:0005750]		mitochondrial respiratory chain complex III [GO:0005750]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00127}.
A0A0A0MRZ7	reviewed	KVD26_HUMAN	Immunoglobulin kappa variable 2D-26	IGKV2D-26	Homo sapiens (Human)	120	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0A0MRZ8	reviewed	KVD11_HUMAN	Immunoglobulin kappa variable 3D-11	IGKV3D-11	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0A0MRZ9	reviewed	LV552_HUMAN	Immunoglobulin lambda variable 5-52	IGLV5-52	Homo sapiens (Human)	124	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0A0MS00	reviewed	LV332_HUMAN	Probable non-functional immunoglobulin lambda variable 3-32	IGLV3-32	Homo sapiens (Human)	114	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0A0MS01	reviewed	TVG10_HUMAN	Probable non-functional T cell receptor gamma variable 10	TRGV10	Homo sapiens (Human)	119	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) gamma chain (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0A0A0MS02	reviewed	TRGV1_HUMAN	Probable non-functional T cell receptor gamma variable	TRGV1	Homo sapiens (Human)	117	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) gamma chain (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]	external side of plasma membrane [GO:0009897]; T cell receptor complex [GO:0042101]		external side of plasma membrane [GO:0009897]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0A0A0MS03	reviewed	TVB53_HUMAN	Probable non-functional T cell receptor beta variable 5-3	TRBV5-3	Homo sapiens (Human)	114	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000269|PubMed:9619395, ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A0MS04	reviewed	TVB67_HUMAN	Probable non-functional T cell receptor beta variable 6-7	TRBV6-7	Homo sapiens (Human)	114	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000269|PubMed:9619395, ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A0MS05	reviewed	TVB57_HUMAN	Probable non-functional T cell receptor beta variable 5-7	TRBV5-7	Homo sapiens (Human)	114	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000269|PubMed:9619395, ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A0MS06	reviewed	TVB23_HUMAN	Probable non-functional T cell receptor beta variable 23-1	TRBV23-1	Homo sapiens (Human)	115	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000269|PubMed:9619395, ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A0MS14	reviewed	HV145_HUMAN	Immunoglobulin heavy variable 1-45	IGHV1-45	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0A0MS15	reviewed	HV349_HUMAN	Immunoglobulin heavy variable 3-49	IGHV3-49	Homo sapiens (Human)	119	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0A0MT36	reviewed	KVD21_HUMAN	Immunoglobulin kappa variable 6D-21	IGKV6D-21	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0A6YYC5	reviewed	TVA14_HUMAN	T cell receptor alpha variable 14/delta variable 4	TRAV14DV4	Homo sapiens (Human)	116	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; T cell receptor complex [GO:0042101]		extracellular space [GO:0005615]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A6YYD4	reviewed	TVB13_HUMAN	T cell receptor beta variable 13	TRBV13	Homo sapiens (Human)	124	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A6YYG2	reviewed	TVB66_HUMAN	T cell receptor beta variable 6-6	TRBV6-6	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A6YYG3	reviewed	TVB68_HUMAN	T cell receptor beta variable 6-8	TRBV6-8	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A6YYJ7	reviewed	TVA83_HUMAN	T cell receptor alpha variable 8-3	TRAV8-3	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A6YYK1	reviewed	TVA81_HUMAN	T cell receptor alpha variable 8-1	TRAV8-1	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A6YYK4	reviewed	TVB71_HUMAN	Probable non-functional T cell receptor beta variable 7-1	TRBV7-1	Homo sapiens (Human)	115	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000269|PubMed:9619395, ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A6YYK6	reviewed	TVA16_HUMAN	T cell receptor alpha variable 16	TRAV16	Homo sapiens (Human)	109	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A6YYK7	reviewed	TVA19_HUMAN	T cell receptor alpha variable 19 (T-cell receptor alpha chain V region HPB-MLT)	TRAV19	Homo sapiens (Human)	116	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A6YYL3	reviewed	POTEB_HUMAN	POTE ankyrin domain family member B (ANKRD26-like family B member 1) (Prostate, ovary, testis-expressed protein on chromosome 15) (POTE-15)	POTEB	Homo sapiens (Human)	544							
A0A0B4J1U3	reviewed	LV136_HUMAN	Immunoglobulin lambda variable 1-36	IGLV1-36	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J1U4	reviewed	TRGV5_HUMAN	T cell receptor gamma variable 5	TRGV5 TCRGV5	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]; innate immune response [GO:0045087]	external side of plasma membrane [GO:0009897]; T cell receptor complex [GO:0042101]		external side of plasma membrane [GO:0009897]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0A0B4J1U6	reviewed	TVB9_HUMAN	T cell receptor beta variable 9	TRBV9	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J1U7	reviewed	HV601_HUMAN	Immunoglobulin heavy variable 6-1	IGHV6-1	Homo sapiens (Human)	121	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J1V0	reviewed	HV315_HUMAN	Immunoglobulin heavy variable 3-15	IGHV3-15	Homo sapiens (Human)	119	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J1V1	reviewed	HV321_HUMAN	Immunoglobulin heavy variable 3-21	IGHV3-21	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J1V2	reviewed	HV226_HUMAN	Immunoglobulin heavy variable 2-26	IGHV2-26	Homo sapiens (Human)	119	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J1V6	reviewed	HV373_HUMAN	Immunoglobulin heavy variable 3-73	IGHV3-73	Homo sapiens (Human)	119	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J1V7	reviewed	HV781_HUMAN	Probable non-functional immunoglobulin heavy variable 7-81	IGHV7-81	Homo sapiens (Human)	117	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J1X5	reviewed	HV374_HUMAN	Immunoglobulin heavy variable 3-74	IGHV3-74	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J1X8	reviewed	HV343_HUMAN	Immunoglobulin heavy variable 3-43	IGHV3-43	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J1Y8	reviewed	LV949_HUMAN	Immunoglobulin lambda variable 9-49	IGLV9-49	Homo sapiens (Human)	123	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J1Y9	reviewed	HV372_HUMAN	Immunoglobulin heavy variable 3-72	IGHV3-72	Homo sapiens (Human)	119	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J1Z2	reviewed	KVD43_HUMAN	Immunoglobulin kappa variable 1D-43	IGKV1D-43	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J234	reviewed	TVA2_HUMAN	T cell receptor alpha variable 2	TRAV2	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; T cell receptor complex [GO:0042101]		extracellular space [GO:0005615]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J235	reviewed	TVAM2_HUMAN	T cell receptor alpha variable 13-2	TRAV13-2	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J237	reviewed	TVA82_HUMAN	T cell receptor alpha variable 8-2	TRAV8-2	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J238	reviewed	TVA12_HUMAN	T cell receptor alpha variable 1-2	TRAV1-2	Homo sapiens (Human)	106	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J240	reviewed	TVA10_HUMAN	T cell receptor alpha variable 10	TRAV10	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J241	reviewed	TVAM1_HUMAN	T cell receptor alpha variable 13-1	TRAV13-1	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J244	reviewed	TVA3_HUMAN	T cell receptor alpha variable 3	TRAV3	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J245	reviewed	TVAL1_HUMAN	T cell receptor alpha variable 12-1	TRAV12-1	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]	peptide antigen binding [GO:0042605]	T cell receptor complex [GO:0042101]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J248	reviewed	TVA11_HUMAN	T cell receptor alpha variable 1-1	TRAV1-1	Homo sapiens (Human)	108	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J249	reviewed	TVA5_HUMAN	T cell receptor alpha variable 5	TRAV5	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J262	reviewed	TVA86_HUMAN	T cell receptor alpha variable 8-6	TRAV8-6	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J263	reviewed	TVA39_HUMAN	T cell receptor alpha variable 39	TRAV39	Homo sapiens (Human)	110	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J264	reviewed	TV381_HUMAN	T cell receptor alpha variable 38-1	TRAV38-1	Homo sapiens (Human)	116	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; T cell receptor complex [GO:0042101]		extracellular space [GO:0005615]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J265	reviewed	TVAZ2_HUMAN	T cell receptor alpha variable 26-2	TRAV26-2	Homo sapiens (Human)	109	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J266	reviewed	TVA41_HUMAN	T cell receptor alpha variable 41	TRAV41	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J268	reviewed	TVA4_HUMAN	T cell receptor alpha variable 4	TRAV4	Homo sapiens (Human)	109	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J271	reviewed	TVAL3_HUMAN	T cell receptor alpha variable 12-3	TRAV12-3	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]	peptide antigen binding [GO:0042605]	T cell receptor complex [GO:0042101]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J272	reviewed	TVA24_HUMAN	T cell receptor alpha variable 24	TRAV24	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J273	reviewed	TVA34_HUMAN	T cell receptor alpha variable 34	TRAV34	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J274	reviewed	TVA20_HUMAN	T cell receptor alpha variable 20	TRAV20	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J275	reviewed	TVA17_HUMAN	T cell receptor alpha variable 17	TRAV17	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J276	reviewed	TVA25_HUMAN	T cell receptor alpha variable 25	TRAV25	Homo sapiens (Human)	109	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J277	reviewed	TVA22_HUMAN	T cell receptor alpha variable 22	TRAV22	Homo sapiens (Human)	110	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J279	reviewed	TVA21_HUMAN	T cell receptor alpha variable 21	TRAV21	Homo sapiens (Human)	112	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J280	reviewed	TVA40_HUMAN	T cell receptor alpha variable 40	TRAV40	Homo sapiens (Human)	105	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J2D5	reviewed	GAL3B_HUMAN	Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (Keio novel protein-I) (KNP-I) (Protein GT335) (Protein HES1)	GATD3B HES1 KNPI	Homo sapiens (Human)	268				mitochondrion [GO:0005739]		mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
A0A0B4J2D9	reviewed	KVD13_HUMAN	Immunoglobulin kappa variable 1D-13	IGKV1D-13	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0B4J2E0	reviewed	TVBL4_HUMAN	T cell receptor beta variable 12-4	TRBV12-4	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J2H0	reviewed	HV69D_HUMAN	Immunoglobulin heavy variable 1-69D	IGHV1-69D	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH24	reviewed	KV621_HUMAN	Immunoglobulin kappa variable 6-21	IGKV6-21	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH25	reviewed	KVD20_HUMAN	Immunoglobulin kappa variable 3D-20	IGKV3D-20	Homo sapiens (Human)	116	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH26	reviewed	KVD41_HUMAN	Probable non-functional immunoglobulin kappa variable 6D-41	IGKV6D-41	Homo sapiens (Human)	115	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH27	reviewed	TRGV8_HUMAN	T cell receptor gamma variable 8	TRGV8 TCRGV8	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]; innate immune response [GO:0045087]	external side of plasma membrane [GO:0009897]; T cell receptor complex [GO:0042101]		external side of plasma membrane [GO:0009897]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0A0C4DH28	reviewed	TRGV4_HUMAN	T cell receptor gamma variable 4	TRGV4 TCRGV4	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]; innate immune response [GO:0045087]	external side of plasma membrane [GO:0009897]; T cell receptor complex [GO:0042101]		external side of plasma membrane [GO:0009897]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0A0C4DH29	reviewed	HV103_HUMAN	Immunoglobulin heavy variable 1-3	IGHV1-3	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH30	reviewed	HV316_HUMAN	Probable non-functional immunoglobulin heavy variable 3-16	IGHV3-16	Homo sapiens (Human)	117	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH31	reviewed	HV118_HUMAN	Immunoglobulin heavy variable 1-18	IGHV1-18	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH32	reviewed	HV320_HUMAN	Immunoglobulin heavy variable 3-20	IGHV3-20	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH33	reviewed	HV124_HUMAN	Immunoglobulin heavy variable 1-24	IGHV1-24	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH34	reviewed	HV428_HUMAN	Immunoglobulin heavy variable 4-28	IGHV4-28	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH35	reviewed	HV335_HUMAN	Probable non-functional immunoglobulin heavy variable 3-35	IGHV3-35	Homo sapiens (Human)	117	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH36	reviewed	HV338_HUMAN	Probable non-functional immunoglobulin heavy variable 3-38	IGHV3-38	Homo sapiens (Human)	116	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH38	reviewed	HV551_HUMAN	Immunoglobulin heavy variable 5-51	IGHV5-51	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH39	reviewed	HV158_HUMAN	Immunoglobulin heavy variable 1-58	IGHV1-58	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH41	reviewed	HV461_HUMAN	Immunoglobulin heavy variable 4-61	IGHV4-61	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH42	reviewed	HV366_HUMAN	Immunoglobulin heavy variable 3-66	IGHV3-66	Homo sapiens (Human)	116	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH43	reviewed	HV70D_HUMAN	Immunoglobulin heavy variable 2-70D	IGHV2-70D	Homo sapiens (Human)	119	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH55	reviewed	KVD07_HUMAN	Immunoglobulin kappa variable 3D-7	IGKV3D-7	Homo sapiens (Human)	119	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH59	reviewed	TVB54_HUMAN	T cell receptor beta variable 5-4	TRBV5-4	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0C4DH67	reviewed	KV108_HUMAN	Immunoglobulin kappa variable 1-8	IGKV1-8	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH68	reviewed	KV224_HUMAN	Immunoglobulin kappa variable 2-24	IGKV2-24	Homo sapiens (Human)	120	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH69	reviewed	KV109_HUMAN	Immunoglobulin kappa variable 1-9	IGKV1-9	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH72	reviewed	KV106_HUMAN	Immunoglobulin kappa variable 1-6	IGKV1-6	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0C4DH73	reviewed	KV112_HUMAN	Immunoglobulin kappa variable 1-12	IGKV1-12	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0G2JMI3	reviewed	HV692_HUMAN	Immunoglobulin heavy variable 1-69-2	IGHV1-69-2	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0G2JS06	reviewed	LV539_HUMAN	Immunoglobulin lambda variable 5-39	IGLV5-39	Homo sapiens (Human)	123	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0J9YVY3	reviewed	HV741_HUMAN	Immunoglobulin heavy variable 7-4-1	IGHV7-4-1	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0J9YX35	reviewed	HV64D_HUMAN	Immunoglobulin heavy variable 3-64D	IGHV3-64D	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0J9YX75	reviewed	TVB69_HUMAN	T cell receptor beta variable 6-9	TRBV6-9	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0J9YXX1	reviewed	HV5X1_HUMAN	Immunoglobulin heavy variable 5-10-1	IGHV5-10-1	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0J9YXY3	reviewed	TVB62_HUMAN	T cell receptor beta variable 6-2	TRBV6-2	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0K0K1A3	reviewed	TVBJ1_HUMAN	T cell receptor beta variable 10-1	TRBV10-1	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0K0K1B3	reviewed	TVB30_HUMAN	T cell receptor beta variable 30	TRBV30	Homo sapiens (Human)	111	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0K0K1C0	reviewed	TVBK1_HUMAN	T cell receptor beta variable 11-1	TRBV11-1	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0K0K1C4	reviewed	TVB27_HUMAN	T cell receptor beta variable 27	TRBV27	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0K0K1D8	reviewed	TVB61_HUMAN	T cell receptor beta variable 6-1	TRBV6-1	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0K0K1E9	reviewed	TVB77_HUMAN	T cell receptor beta variable 7-7	TRBV7-7	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0K0K1G6	reviewed	TVBJ3_HUMAN	T cell receptor beta variable 10-3	TRBV10-3	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0K0K1G8	reviewed	TVBJ2_HUMAN	T cell receptor beta variable 10-2	TRBV10-2	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0U1RQF7	reviewed	DP2NB_HUMAN	DPEP2 neighbor protein	DPEP2NB	Homo sapiens (Human)	123							
A0A0U1RRN3	reviewed	MISFA_HUMAN	Mitochondrial sheath formation-associated protein (Putative transmembrane protein SPTY2D1OS) (SPTY2D1 antisense RNA 1) (SPTY2D1 opposite strand)	MISFA SPTY2D1-AS1 SPTY2D1OS	Homo sapiens (Human)	59	FUNCTION: [Isoform Kastor]: Regulates sperm development. May be involved in mitochondrial sheath formation. {ECO:0000250|UniProtKB:Q8C5Y2}.; FUNCTION: [Isoform Polluks]: Regulates sperm development. May be involved in mitochondrial sheath formation. {ECO:0000250|UniProtKB:Q8C5Y2}.	MISCELLANEOUS: Isoform Kastor and isoform Polluks are conserved only in mammals. {ECO:0000250|UniProtKB:Q8C5Y2}.		mitochondrial outer membrane [GO:0005741]		mitochondrial outer membrane [GO:0005741]	SUBCELLULAR LOCATION: [Isoform Kastor]: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8C5Y2}; Single-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform Polluks]: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8C5Y2}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GTK4	reviewed	F237A_HUMAN	Protein FAM237A	FAM237A	Homo sapiens (Human)	181	FUNCTION: May be capable of activating GPR83 via the GNAQ signaling pathway. {ECO:0000269|PubMed:32713278}.			extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:32713278}.
A0A1B0GUS4	reviewed	UB2L5_HUMAN	Ubiquitin-conjugating enzyme E2 L5 (EC 2.3.2.23) (Ubiquitin-protein ligase L5)	UBE2L5	Homo sapiens (Human)	154	FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins. {ECO:0000255|PROSITE-ProRule:PRU00388}.		protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	ATP binding [GO:0005524]; ligase activity [GO:0016874]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]	nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ligase activity [GO:0016874]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	
A0A1B0GVD1	reviewed	F237B_HUMAN	Protein FAM237B	FAM237B	Homo sapiens (Human)	139	FUNCTION: May be capable of activating GPR83 via the GNAQ signaling pathway. {ECO:0000269|PubMed:32713278}.			extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:32713278}.
A0A1B0GX31	reviewed	TVB76_HUMAN	T cell receptor beta variable 7-6	TRBV7-6	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A1B0GX49	reviewed	TVB64_HUMAN	T cell receptor beta variable 6-4	TRBV6-4	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A1B0GX51	reviewed	TVB78_HUMAN	T cell receptor beta variable 7-8	TRBV7-8	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A1B0GX56	reviewed	TRDV1_HUMAN	T cell receptor delta variable 1	TRDV1	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]; innate immune response [GO:0045087]	extracellular space [GO:0005615]; T cell receptor complex [GO:0042101]		extracellular space [GO:0005615]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0A1B0GX68	reviewed	TVB2_HUMAN	T cell receptor beta variable 2	TRBV2	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A1B0GX78	reviewed	TVBL5_HUMAN	T cell receptor beta variable 12-5	TRBV12-5	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A1B0GX95	reviewed	TVB74_HUMAN	T cell receptor beta variable 7-4	TRBV7-4	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A1B0GXF2	reviewed	TVB72_HUMAN	T cell receptor beta variable 7-2	TRBV7-2	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A1W2PPD8	reviewed	KDM4F_HUMAN	Probable lysine-specific demethylase 4F (EC 1.14.11.66)	KDM4F	Homo sapiens (Human)	638	FUNCTION: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. {ECO:0000250|UniProtKB:B2RXH2}.		chromatin remodeling [GO:0006338]; regulation of gene expression [GO:0010468]	chromatin [GO:0000785]; nucleus [GO:0005634]	histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]	chromatin [GO:0000785]; nucleus [GO:0005634]; histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; chromatin remodeling [GO:0006338]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
A0A1W2PPM1	reviewed	CPHXL_HUMAN	Cytoplasmic polyadenylated homeobox-like protein (Cytoplasmic polyadenylated homeobox 1)	CPHXL CPHX1	Homo sapiens (Human)	405	FUNCTION: Transcription factor that acts as activator. {ECO:0000269|PubMed:27412763}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A0A1W2PQD8	reviewed	S72L2_HUMAN	RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 2 (RNA polymerase II subunit A C-terminal domain phosphatase SSU72L2) (CTD phosphatase SSU72L2) (EC 3.1.3.16)	SSU72L2 SSU72P2	Homo sapiens (Human)	194	FUNCTION: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. {ECO:0000250|UniProtKB:Q9NP77}.		mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]	myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NP77}.
A0A1W2PR19	reviewed	GSTT4_HUMAN	Glutathione S-transferase theta-4 (EC 2.5.1.18) (GST class-theta-4) (Glutathione S-transferase theta pseudogene 1)	GSTT4 GSTTP1	Homo sapiens (Human)	241	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000250|UniProtKB:P30711}.		glutathione metabolic process [GO:0006749]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	glutathione transferase activity [GO:0004364]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutathione transferase activity [GO:0004364]; glutathione metabolic process [GO:0006749]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
A0A1W2PR82	reviewed	PERC1_HUMAN	Protein PERCC1 (Proline and glutamage-rich protein with a coiled coil domain)	PERCC1	Homo sapiens (Human)	267	FUNCTION: Plays a critical role in intestinal function (PubMed:31217582). Acts by promoting the development of enteroendocrine cells (EECs) of the gastrointestinal tract and pancreas (By similarity). It is thereby required for normal enteroendocrine peptide hormone secretion (By similarity). {ECO:0000250|UniProtKB:A0A286YDK6, ECO:0000269|PubMed:31217582}.		digestive tract morphogenesis [GO:0048546]; enteroendocrine cell differentiation [GO:0035883]			digestive tract morphogenesis [GO:0048546]; enteroendocrine cell differentiation [GO:0035883]	
A0A2R8Y619	reviewed	H2BK1_HUMAN	Histone H2B type 2-K1 (Histone H2B type 2-E1)	H2BK1 H2BE1	Homo sapiens (Human)	122	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000250|UniProtKB:P70696}.			nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:P70696}. Nucleus {ECO:0000250|UniProtKB:P70696}.
A0A2Z4LIS9	reviewed	FXO3B_HUMAN	Forkhead box protein O3B	FOXO3B	Homo sapiens (Human)	290	FUNCTION: Transcription factor. {ECO:0000250|UniProtKB:Q9R1E0}.		regulation of transcription by RNA polymerase II [GO:0006357]	cytosol [GO:0005829]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:29925039}. Note=Does not translocate to the nucleus upon phosphorylation. {ECO:0000269|PubMed:29925039}.
A0A3B3IS91	reviewed	PLGRF_HUMAN	POLG alternative reading frame (POLGARF) (ORF-Y) [Cleaved into: POLGARF C-terminal fragment (POLGARFin)]	POLGARF	Homo sapiens (Human)	260				extracellular space [GO:0005615]; nucleolus [GO:0005730]		extracellular space [GO:0005615]; nucleolus [GO:0005730]	SUBCELLULAR LOCATION: [POLG alternative reading frame]: Nucleus, nucleolus {ECO:0000269|PubMed:32958672}.; SUBCELLULAR LOCATION: [POLGARF C-terminal fragment]: Secreted {ECO:0000269|PubMed:32958672}.
A0A3B3IT33	reviewed	TR51G_HUMAN	Putative tripartite motif-containing protein 51G (Tripartite motif-containing 51G pseudogene)	TRIM51G TRIM51GP	Homo sapiens (Human)	452			innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
A0A455ZAR2	reviewed	PNT87_HUMAN	Transcriptional regulator PINT87aa	LINC-PINT	Homo sapiens (Human)	87	FUNCTION: Enhances the binding of the PAF1 complex to target gene promoters and plays a role in negative regulation of transcription (PubMed:30367041). May function as an anchor to keep the PAF1 complex on target gene promoters, sequentially pausing RNA polymerase II-induced mRNA elongation (PubMed:30367041). Inhibits FOXM1-mediated transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:30367041, ECO:0000269|PubMed:33754036}.	MISCELLANEOUS: Encoded by the circular form of the long non-coding RNA LINC-PINT. {ECO:0000269|PubMed:30367041}.; MISCELLANEOUS: Suppresses glioblastoma cell proliferation and shows decreased expression in glioblastomas compared to normal non-tumor brain tissue (PubMed:30367041). Induces growth inhibition and cellular sensescence and decreases mitophagy in hepatocellular carcinoma (HCC) cells with higher levels of expression in non-tumor tissue than in adjacent HCC tissue (PubMed:33754036). {ECO:0000269|PubMed:30367041, ECO:0000269|PubMed:33754036}.	negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30367041}.
A0A494C1R9	reviewed	TSPY9_HUMAN	Testis-specific Y-encoded protein 9	TSPY9 TSPY9P	Homo sapiens (Human)	314	FUNCTION: May be involved in sperm differentiation and proliferation. {ECO:0000250|UniProtKB:Q01534}.		cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01534}. Nucleus {ECO:0000250|UniProtKB:Q01534}.
A0A539	reviewed	TVB42_HUMAN	T cell receptor beta variable 4-2	TRBV4-2 TCRBV7S3A2 TCRBV7S3A2T	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A576	reviewed	TVB31_HUMAN	T cell receptor beta variable 3-1	TRBV3-1 TCRBV9S1A1T	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A577	reviewed	TVB41_HUMAN	T cell receptor beta variable 4-1	TRBV4-1 TCRBV7S1A1N2T	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A578	reviewed	TVB51_HUMAN	T cell receptor beta variable 5-1	TRBV5-1 TCRBV5S1A1T	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A584	reviewed	TVBK2_HUMAN	T cell receptor beta variable 11-2	TRBV11-2 TCRBV21S3A2N2T	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A589	reviewed	TVB43_HUMAN	T cell receptor beta variable 4-3	TRBV4-3 TCRBV7S2A1N4T	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A590UK83	reviewed	SMI45_HUMAN	Small integral membrane protein 45	SMIM45 LINC00634	Homo sapiens (Human)	68	FUNCTION: Plays a role in the regulation of neuron maturation. {ECO:0000269|PubMed:36593289}.		nervous system development [GO:0007399]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:36593289}. Cytoplasm {ECO:0000269|PubMed:36593289}. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A597	reviewed	TVB55_HUMAN	T cell receptor beta variable 5-5	TRBV5-5 TCRBV5S3A2T	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A599	reviewed	TVB56_HUMAN	T cell receptor beta variable 5-6	TRBV5-6 TCRBV5S2	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A5A2	reviewed	TVB58_HUMAN	T cell receptor beta variable 5-8	TRBV5-8 TCRBV5S4A2T	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A5A6	reviewed	TVBK3_HUMAN	T cell receptor beta variable 11-3	TRBV11-3 TCRBV21S2A2	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A5B0	reviewed	TVB14_HUMAN	T cell receptor beta variable 14	TRBV14 TCRBV14S1 TCRBV16S1A1N1	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A5B6	reviewed	TVB28_HUMAN	T cell receptor beta variable 28	TRBV28 TCRBV3S1	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	peptide antigen binding [GO:0042605]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A5B7	reviewed	TVB29_HUMAN	T cell receptor beta variable 29-1	TRBV29-1 TCRBV4S1A1T	Homo sapiens (Human)	111	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A7L8Y648	reviewed	MIAC_HUMAN	Micropeptide inhibiting actin cytoskeleton	AQP5-AS1 MIAC	Homo sapiens (Human)	51	FUNCTION: Reduces filamentous actin fibers by interacting with aquaporin AQP2 which leads to inhibition of the expression of SEPTIN4 and integrin ITGB4 (PubMed:32176498). Also inhibits the activation of the EREG/EGFR signaling pathway through interaction with AQP2 (PubMed:36117171). {ECO:0000269|PubMed:32176498, ECO:0000269|PubMed:36117171}.	MISCELLANEOUS: Inhibits head and neck squamous cell carcinoma (HNSCC) progression in vitro (PubMed:32176498). Also inhibits renal cell carcinoma progression in vitro (PubMed:36117171). {ECO:0000269|PubMed:32176498, ECO:0000269|PubMed:36117171}.	actin filament organization [GO:0007015]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]			actin filament organization [GO:0007015]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]	
A0A804HLA8	reviewed	GBG5B_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5B	GNG5B GNG5P2	Homo sapiens (Human)	68	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]	heterotrimeric G-protein complex [GO:0005834]	G-protein beta-subunit binding [GO:0031681]	heterotrimeric G-protein complex [GO:0005834]; G-protein beta-subunit binding [GO:0031681]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P63212}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000250|UniProtKB:P63212}.
A0AUZ9	reviewed	KAL1L_HUMAN	KAT8 regulatory NSL complex subunit 1-like protein (MSL1v2)	KANSL1L C2orf67	Homo sapiens (Human)	987				NSL complex [GO:0044545]	histone acetyltransferase binding [GO:0035035]	NSL complex [GO:0044545]; histone acetyltransferase binding [GO:0035035]	
A0AVI2	reviewed	FR1L5_HUMAN	Fer-1-like protein 5	FER1L5	Homo sapiens (Human)	2057	FUNCTION: Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation. {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: Gene prediction based on partial mRNA data. {ECO:0000305}.	regulation of neurotransmitter secretion [GO:0046928]	plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; calcium ion binding [GO:0005509]; regulation of neurotransmitter secretion [GO:0046928]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Colocalizes with EHD1 and EHD2 at plasma membrane in myoblasts and myotubes. Localizes into foci at the plasma membrane (By similarity). {ECO:0000250}.
A0JD32	reviewed	TV382_HUMAN	T cell receptor alpha variable 38-2/delta variable 8	TRAV38-2DV8	Homo sapiens (Human)	116	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; T cell receptor complex [GO:0042101]		extracellular space [GO:0005615]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0JD36	reviewed	TRDV2_HUMAN	T cell receptor delta variable 2	TRDV2 hDV102S1	Homo sapiens (Human)	115	FUNCTION: V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]; innate immune response [GO:0045087]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0JD37	reviewed	TRDV3_HUMAN	T cell receptor delta variable 3	TRDV3 hDV103S1	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]; innate immune response [GO:0045087]	extracellular space [GO:0005615]; T cell receptor complex [GO:0042101]		extracellular space [GO:0005615]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0PJE2	reviewed	DHR12_HUMAN	Dehydrogenase/reductase SDR family member 12 (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 40C member 1) (Protein SDR40C1)	DHRS12 SDR40C1	Homo sapiens (Human)	317	FUNCTION: Putative oxidoreductase. {ECO:0000250}.				oxidoreductase activity [GO:0016491]	oxidoreductase activity [GO:0016491]	
A0PJX4	reviewed	SHSA3_HUMAN	Protein shisa-3 homolog	SHISA3	Homo sapiens (Human)	238	FUNCTION: Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. {ECO:0000250}.		negative regulation of canonical Wnt signaling pathway [GO:0090090]	endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]; negative regulation of canonical Wnt signaling pathway [GO:0090090]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250, ECO:0000250|UniProtKB:Q7T0Z7}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q7T0Z7}.
A0ZSE6	reviewed	CC50C_HUMAN	Cell cycle control protein 50C (Transmembrane protein 30C)	TMEM30CP CDC50C TMEM30C	Homo sapiens (Human)	113			macromolecule localization [GO:0033036]	membrane [GO:0016020]		membrane [GO:0016020]; macromolecule localization [GO:0033036]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A1A4F0	reviewed	S66AL_HUMAN	Putative uncharacterized protein SLC66A1L (PQ-loop repeat-containing protein 2-like) (Solute carrier family 66 member 1-like)	SLC66A1L C3orf55 PQLC2L	Homo sapiens (Human)	135				lysosomal membrane [GO:0005765]	L-lysine transmembrane transporter activity [GO:0015189]	lysosomal membrane [GO:0005765]; L-lysine transmembrane transporter activity [GO:0015189]	
A1A4V9	reviewed	CF119_HUMAN	Cilia- and flagella-associated protein 119 (Coiled-coil domain-containing protein 189)	CFAP119 C16orf93 CCDC189	Homo sapiens (Human)	331				acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; sperm principal piece [GO:0097228]		acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; sperm principal piece [GO:0097228]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:B0BMZ6}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:B0BMZ6}. Cytoplasm {ECO:0000250|UniProtKB:B0BMZ6}. Note=In elongated spermatids, enriched in the principal piece of flagella where it is peri-axonemal. Disappears from sperm heads upon acrosome reaction. {ECO:0000250|UniProtKB:B0BMZ6}.
A1A580	reviewed	KR231_HUMAN	Keratin-associated protein 23-1	KRTAP23-1 KAP23.1	Homo sapiens (Human)	65	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
A1L168	reviewed	CT202_HUMAN	Uncharacterized protein C20orf202	C20orf202	Homo sapiens (Human)	99							
A1L1A6	reviewed	IGS23_HUMAN	Immunoglobulin superfamily member 23	IGSF23	Homo sapiens (Human)	192	FUNCTION: May be involved in osteoclast differentiation. {ECO:0000250|UniProtKB:B2RTN2}.		osteoclast differentiation [GO:0030316]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; osteoclast differentiation [GO:0030316]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31560140}; Single-pass membrane protein {ECO:0000255}.
A1L3X4	reviewed	MT1DP_HUMAN	Putative metallothionein MT1DP	MT1DP MTM	Homo sapiens (Human)	49	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals. {ECO:0000250}.		cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]	
A1L453	reviewed	PRS38_HUMAN	Serine protease 38 (EC 3.4.21.-) (Marapsin-2)	PRSS38 MPN2	Homo sapiens (Human)	326			proteolysis [GO:0006508]	extracellular region [GO:0005576]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A2A3N6	reviewed	PIPSL_HUMAN	Putative PIP5K1A and PSMD4-like protein (PIP5K1A-PSMD4)	PIPSL PSMD4P2	Homo sapiens (Human)	862	FUNCTION: Has negligible PIP5 kinase activity. Binds to ubiquitinated proteins.	MISCELLANEOUS: PIPSL gene appeared in hominoids by L1-mediated retrotransposition in a hominoid ancestor of a readthrough, intergenically spliced transcript between the PIP5K1A and PSMD4 genes.	phosphatidylinositol phosphate biosynthetic process [GO:0046854]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17623810}.
A2AJT9	reviewed	BCLA3_HUMAN	BCLAF1 and THRAP3 family member 3	BCLAF3 CXorf23	Homo sapiens (Human)	711			positive regulation of transcription by RNA polymerase II [GO:0045944]	mediator complex [GO:0016592]; mitochondrion [GO:0005739]	DNA binding [GO:0003677]; transcription coregulator activity [GO:0003712]	mediator complex [GO:0016592]; mitochondrion [GO:0005739]; DNA binding [GO:0003677]; transcription coregulator activity [GO:0003712]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
A2CJ06	reviewed	DYTN_HUMAN	Dystrotelin	DYTN	Homo sapiens (Human)	578			synaptic signaling [GO:0099536]	plasma membrane [GO:0005886]; synapse [GO:0045202]	zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]; synapse [GO:0045202]; zinc ion binding [GO:0008270]; synaptic signaling [GO:0099536]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
A2NJV5	reviewed	KV229_HUMAN	Immunoglobulin kappa variable 2-29	IGKV2-29	Homo sapiens (Human)	120	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A2RRH5	reviewed	WDR27_HUMAN	WD repeat-containing protein 27	WDR27	Homo sapiens (Human)	827				nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	
A2RRL7	reviewed	TM213_HUMAN	Transmembrane protein 213	TMEM213	Homo sapiens (Human)	107				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A2RTY3	reviewed	HEAT9_HUMAN	Protein HEATR9 (HEAT repeat-containing protein 9)	HEATR9 C17orf66	Homo sapiens (Human)	570			hematopoietic progenitor cell differentiation [GO:0002244]			hematopoietic progenitor cell differentiation [GO:0002244]	
A2RU48	reviewed	SMCO3_HUMAN	Single-pass membrane and coiled-coil domain-containing protein 3	SMCO3 C12orf69	Homo sapiens (Human)	225				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A2RU54	reviewed	HMX2_HUMAN	Homeobox protein HMX2 (Homeobox protein H6 family member 2)	HMX2	Homo sapiens (Human)	273	FUNCTION: Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. {ECO:0000250}.		brain development [GO:0007420]; cell differentiation [GO:0030154]; epithelial cell proliferation [GO:0050673]; inner ear morphogenesis [GO:0042472]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of stem cell proliferation [GO:2000648]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell proliferation [GO:0072089]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; brain development [GO:0007420]; cell differentiation [GO:0030154]; epithelial cell proliferation [GO:0050673]; inner ear morphogenesis [GO:0042472]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of stem cell proliferation [GO:2000648]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell proliferation [GO:0072089]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A2RUR9	reviewed	C144A_HUMAN	Coiled-coil domain-containing protein 144A	CCDC144A KIAA0565	Homo sapiens (Human)	1427	FUNCTION: May play a role in preventing the formation of kidney stones through inhibition of calcium oxalate monohydrate (COM) crystallization, attenuating COM-induced apoptotic injury to renal epithelial cells (PubMed:32991878). May exhibit antilithiatic (preventing the formation of kidney stones) activity through crystal binding, hindering the crystal attachment to renal epithelial cells, a pre-requisite to initiate inflammatory response (PubMed:32991878). {ECO:0000269|PubMed:32991878}.						
A2RUU4	reviewed	COLL1_HUMAN	Colipase-like protein 1	CLPSL1 C6orf127	Homo sapiens (Human)	121			digestion [GO:0007586]; lipid catabolic process [GO:0016042]; response to food [GO:0032094]	extracellular region [GO:0005576]	enzyme activator activity [GO:0008047]	extracellular region [GO:0005576]; enzyme activator activity [GO:0008047]; digestion [GO:0007586]; lipid catabolic process [GO:0016042]; response to food [GO:0032094]	SUBCELLULAR LOCATION: Secreted {ECO:0000255|PROSITE-ProRule:PRU00674}.
A2VCK2	reviewed	DCD2B_HUMAN	Doublecortin domain-containing protein 2B	DCDC2B	Homo sapiens (Human)	349			intracellular signal transduction [GO:0035556]	microtubule [GO:0005874]; microtubule organizing center [GO:0005815]		microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; intracellular signal transduction [GO:0035556]	
A3KFT3	reviewed	OR2M5_HUMAN	Olfactory receptor 2M5	OR2M5 OR2M5P	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A4D0V7	reviewed	CPED1_HUMAN	Cadherin-like and PC-esterase domain-containing protein 1	CPED1 C7orf58 UNQ9432/PRO34713	Homo sapiens (Human)	1026				endoplasmic reticulum [GO:0005783]		endoplasmic reticulum [GO:0005783]	
A4D1E1	reviewed	Z804B_HUMAN	Zinc finger protein 804B	ZNF804B	Homo sapiens (Human)	1349				nucleus [GO:0005634]	metal ion binding [GO:0046872]	nucleus [GO:0005634]; metal ion binding [GO:0046872]	
A4D1S0	reviewed	KLRG2_HUMAN	Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B)	KLRG2 CLEC15B	Homo sapiens (Human)	409				membrane [GO:0016020]	carbohydrate binding [GO:0030246]	membrane [GO:0016020]; carbohydrate binding [GO:0030246]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A4D1U4	reviewed	DEN11_HUMAN	DENN domain-containing protein 11 (DENND11) (Protein LCHN)	DENND11 KIAA1147 LCHN	Homo sapiens (Human)	455	FUNCTION: Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). {ECO:0000250|UniProtKB:Q0PGW2, ECO:0000305}.			cytoplasm [GO:0005737]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor activity [GO:0005085]	
A4D2G3	reviewed	O2A25_HUMAN	Olfactory receptor 2A25 (Olfactory receptor 2A27)	OR2A25 OR2A25P OR2A27	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A4D2H0	reviewed	CTGEF_HUMAN	cTAGE family member 15 (Protein cTAGE-15)	CTAGE15 CTAGE15P	Homo sapiens (Human)	777			endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A4D2P6	reviewed	GRD2I_HUMAN	Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)	GRID2IP	Homo sapiens (Human)	1211	FUNCTION: Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. {ECO:0000250}.		long-term synaptic depression [GO:0060292]; regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]	cerebellar granule cell to Purkinje cell synapse [GO:0150048]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]		cerebellar granule cell to Purkinje cell synapse [GO:0150048]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]; long-term synaptic depression [GO:0060292]; regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250}.
A4QMS7	reviewed	CFA90_HUMAN	Cilia- and flagella-associated protein 90	CFAP90 C5orf49	Homo sapiens (Human)	147	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.			axoneme [GO:0005930]; ciliary basal body [GO:0036064]		axoneme [GO:0005930]; ciliary basal body [GO:0036064]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
A4QPH2	reviewed	PI4P2_HUMAN	Putative phosphatidylinositol 4-kinase alpha-like protein P2	PI4KAP2	Homo sapiens (Human)	592			phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]		kinase activity [GO:0016301]	kinase activity [GO:0016301]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]	
A5PL33	reviewed	KRBA1_HUMAN	Protein KRBA1	KRBA1 KIAA1862	Homo sapiens (Human)	1030							
A5PLK6	reviewed	RGSL_HUMAN	Regulator of G-protein signaling protein-like	RGSL1 RGSL RGSL2	Homo sapiens (Human)	1076				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A5PLN7	reviewed	F149A_HUMAN	Protein FAM149A	FAM149A MST119	Homo sapiens (Human)	773							
A6H8M9	reviewed	CDHR4_HUMAN	Cadherin-related family member 4 (Cadherin-like protein 29)	CDHR4 CDH29 UNQ9392/PRO34300	Homo sapiens (Human)	788	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). {ECO:0000250}.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A6NC42	reviewed	DPPA5_HUMAN	Developmental pluripotency-associated 5 protein (hDPPA5) (Embryonal stem cell-specific gene 1 protein) (ESG-1)	DPPA5 ESG1	Homo sapiens (Human)	116	FUNCTION: Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs (By similarity). {ECO:0000250}.		regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; mRNA binding [GO:0003729]; regulation of gene expression [GO:0010468]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
A6NC78	reviewed	GOG8I_HUMAN	Putative golgin subfamily A member 8I (Golgin subfamily A member 8I pseudogene)	GOLGA8IP GOLGA8I GOLGA9P	Homo sapiens (Human)	632	FUNCTION: May be involved in maintaining Golgi structure. {ECO:0000250}.		Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
A6NC86	reviewed	PINLY_HUMAN	phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein	PINLYP	Homo sapiens (Human)	204				extracellular region [GO:0005576]	phospholipase inhibitor activity [GO:0004859]	extracellular region [GO:0005576]; phospholipase inhibitor activity [GO:0004859]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A6NCC3	reviewed	GOG8O_HUMAN	Golgin subfamily A member 8O	GOLGA8O	Homo sapiens (Human)	632			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
A6NCI4	reviewed	VWA3A_HUMAN	von Willebrand factor A domain-containing protein 3A	VWA3A	Homo sapiens (Human)	1184				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A6NCK2	reviewed	TR43B_HUMAN	Tripartite motif-containing protein 43B	TRIM43B	Homo sapiens (Human)	446			innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
A6NCL1	reviewed	GEMC1_HUMAN	Geminin coiled-coil domain-containing protein 1	GMNC GEMC1	Homo sapiens (Human)	334	FUNCTION: Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity). {ECO:0000250}.		cell cycle [GO:0007049]; cilium assembly [GO:0060271]; DNA replication [GO:0006260]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA replication [GO:0008156]	nucleus [GO:0005634]	chromatin binding [GO:0003682]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; cell cycle [GO:0007049]; cilium assembly [GO:0060271]; DNA replication [GO:0006260]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA replication [GO:0008156]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Associates with chromatin during pre-replication complex (pre-RC) formation. {ECO:0000250}.
A6NCN2	reviewed	KR87P_HUMAN	Putative keratin-87 protein (Keratin, hair, basic pseudogene 4) (Keratin-121 pseudogene)	KRT87P KRT121P KRTHBP4	Homo sapiens (Human)	255		MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).		extracellular space [GO:0005615]; keratin filament [GO:0045095]		extracellular space [GO:0005615]; keratin filament [GO:0045095]	
A6NCV1	reviewed	O6C74_HUMAN	Olfactory receptor 6C74	OR6C74	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NCW7	reviewed	U17L4_HUMAN	Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4	USP17L4	Homo sapiens (Human)	530			regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
A6NDD5	reviewed	SYN1L_HUMAN	Synapse differentiation-inducing gene protein 1-like (Capucin) (Dispanin subfamily C member 1) (DSPC1) (Transmembrane protein 90A)	SYNDIG1L TMEM90A	Homo sapiens (Human)	238				Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]		Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, cis-Golgi network {ECO:0000250}.
A6NDH6	reviewed	O5H15_HUMAN	Olfactory receptor 5H15	OR5H15	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NDI0	reviewed	TR49B_HUMAN	Putative tripartite motif-containing protein 49B (RING finger protein 18B)	TRIM49B RNF18B	Homo sapiens (Human)	452			innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
A6NDL8	reviewed	O6C68_HUMAN	Olfactory receptor 6C68	OR6C68	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NDN3	reviewed	GOG6B_HUMAN	Golgin subfamily A member 6B	GOLGA6B GOLGA	Homo sapiens (Human)	693			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
A6NDR6	reviewed	ME3L1_HUMAN	Putative homeobox protein Meis3-like 1	MEIS3P1	Homo sapiens (Human)	274			animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A6NDS4	reviewed	TBC3B_HUMAN	TBC1 domain family member 3B	TBC1D3B TBC1D3I	Homo sapiens (Human)	549	FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250}.	MISCELLANEOUS: TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor.		plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associated with lipid rafts. {ECO:0000250}.
A6NDX5	reviewed	ZN840_HUMAN	Putative zinc finger protein 840 (Zinc finger protein 840 pseudogene)	ZNF840P C20orf157 ZNF840	Homo sapiens (Human)	716	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
A6NDY0	reviewed	EPAB2_HUMAN	Embryonic polyadenylate-binding protein 2 (Embryonic poly(A)-binding protein 2) (ePABP-2) (ePABP2) (Embryonic poly(A)-binding protein type II) (Poly(A)-binding protein nuclear-like 1)	PABPN1L EPABP2 PABPNL1	Homo sapiens (Human)	278	FUNCTION: Binds the poly(A) tail of mRNA. {ECO:0000250}.		nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	poly(A) binding [GO:0008143]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; poly(A) binding [GO:0008143]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
A6NE52	reviewed	WDR97_HUMAN	WD repeat-containing protein 97	WDR97 KIAA1875	Homo sapiens (Human)	1622							
A6NEC2	reviewed	PSAL_HUMAN	Puromycin-sensitive aminopeptidase-like protein (EC 3.4.11.-)	NPEPPSL1	Homo sapiens (Human)	478	FUNCTION: Aminopeptidase with broad substrate specificity to several peptides. {ECO:0000250}.		peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]	
A6NEL2	reviewed	SWAHB_HUMAN	Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B)	SOWAHB ANKRD56	Homo sapiens (Human)	793							
A6NER0	reviewed	TBC3F_HUMAN	TBC1 domain family member 3F	TBC1D3F TBC1D3E	Homo sapiens (Human)	549	FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250}.	MISCELLANEOUS: TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor. {ECO:0000305}.		plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associated with lipid rafts. {ECO:0000250}.
A6NES4	reviewed	MRO2A_HUMAN	Maestro heat-like repeat-containing protein family member 2A (HEAT repeat-containing protein 7B1)	MROH2A HEATR7B1	Homo sapiens (Human)	1674				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
A6NET4	reviewed	OR5K3_HUMAN	Olfactory receptor 5K3	OR5K3	Homo sapiens (Human)	321	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NF34	reviewed	ANTRL_HUMAN	Anthrax toxin receptor-like	ANTXRL	Homo sapiens (Human)	631				cell surface [GO:0009986]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A6NF89	reviewed	OR6C6_HUMAN	Olfactory receptor 6C6	OR6C6	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			lipid droplet [GO:0005811]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	lipid droplet [GO:0005811]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NFC5	reviewed	TM235_HUMAN	Transmembrane protein 235	TMEM235	Homo sapiens (Human)	223				apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]		apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000305}.
A6NFC9	reviewed	OR2W5_HUMAN	Putative olfactory receptor 2W5 pseudogene	OR2W5P OR2W5	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NFI3	reviewed	ZN316_HUMAN	Zinc finger protein 316	ZNF316	Homo sapiens (Human)	1004	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
A6NFQ7	reviewed	DPRX_HUMAN	Divergent paired-related homeobox	DPRX	Homo sapiens (Human)	191	FUNCTION: Transcription factor that acts as repressor. {ECO:0000269|PubMed:27412763}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A6NFT4	reviewed	CFA73_HUMAN	Cilia- and flagella-associated protein 73 (Coiled-coil domain-containing protein 42B)	CFAP73 CCDC42B	Homo sapiens (Human)	308	FUNCTION: May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. {ECO:0000250|UniProtKB:M1V4Y8}.		cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; spermatid development [GO:0007286]	axonemal outer doublet [GO:0097545]; motile cilium [GO:0031514]	dynein complex binding [GO:0070840]	axonemal outer doublet [GO:0097545]; motile cilium [GO:0031514]; dynein complex binding [GO:0070840]; cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:M1V4Y8}.
A6NG13	reviewed	MGT4D_HUMAN	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D (N-acetylglucosaminyltransferase MGAT1 inhibitory protein) (GlcNAcT-I inhibitory protein) (GnT1IP)	MGAT4D	Homo sapiens (Human)	374	FUNCTION: May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis. {ECO:0000250|UniProtKB:Q9D4R2}.		cell differentiation [GO:0030154]; negative regulation of protein glycosylation [GO:0060051]; protein N-linked glycosylation [GO:0006487]; spermatogenesis [GO:0007283]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]	acetylglucosaminyltransferase activity [GO:0008375]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; acetylglucosaminyltransferase activity [GO:0008375]; cell differentiation [GO:0030154]; negative regulation of protein glycosylation [GO:0060051]; protein N-linked glycosylation [GO:0006487]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q4V8F8}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q4V8F8}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
A6NGD5	reviewed	ZSA5C_HUMAN	Zinc finger and SCAN domain-containing protein 5C (Zinc finger and SCAN domain-containing protein 5C pseudogene)	ZSCAN5C ZSCAN5CP	Homo sapiens (Human)	496	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
A6NGE7	reviewed	URAD_HUMAN	Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase) (EC 4.1.1.97) (Parahox neighbor) (Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase)	URAD PRHOXNB	Homo sapiens (Human)	173	FUNCTION: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. {ECO:0000305}.		allantoin metabolic process [GO:0000255]; purine nucleobase metabolic process [GO:0006144]	peroxisome [GO:0005777]	carboxy-lyase activity [GO:0016831]	peroxisome [GO:0005777]; carboxy-lyase activity [GO:0016831]; allantoin metabolic process [GO:0000255]; purine nucleobase metabolic process [GO:0006144]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000305}.
A6NGJ6	reviewed	TRI64_HUMAN	Tripartite motif-containing protein 64	TRIM64 C11orf28	Homo sapiens (Human)	449			innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
A6NH21	reviewed	SERC4_HUMAN	Serine incorporator 4	SERINC4	Homo sapiens (Human)	518	FUNCTION: Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. {ECO:0000269|PubMed:16120614}.		phospholipid biosynthetic process [GO:0008654]	membrane [GO:0016020]		membrane [GO:0016020]; phospholipid biosynthetic process [GO:0008654]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NH52	reviewed	TV23A_HUMAN	Golgi apparatus membrane protein TVP23 homolog A	TVP23A FAM18A	Homo sapiens (Human)	213			protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]	membrane [GO:0016020]		membrane [GO:0016020]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NH57	reviewed	ARL5C_HUMAN	Putative ADP-ribosylation factor-like protein 5C (ADP-ribosylation factor-like protein 12)	ARL5C ARL12	Homo sapiens (Human)	179	FUNCTION: Binds and exchanges GTP and GDP. {ECO:0000250}.		intracellular protein transport [GO:0006886]; protein localization to Golgi membrane [GO:1903292]; vesicle-mediated transport [GO:0016192]	trans-Golgi network [GO:0005802]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	trans-Golgi network [GO:0005802]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; protein localization to Golgi membrane [GO:1903292]; vesicle-mediated transport [GO:0016192]	
A6NHA9	reviewed	O4C46_HUMAN	Olfactory receptor 4C46	OR4C46	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NHG9	reviewed	O5H14_HUMAN	Olfactory receptor 5H14	OR5H14	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NHJ4	reviewed	ZN860_HUMAN	Zinc finger protein 860	ZNF860	Homo sapiens (Human)	632	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
A6NHM9	reviewed	MOXD2_HUMAN	Putative DBH-like monooxygenase protein 2 (EC 1.14.17.-) (DBH-like monooxygenase protein 2 pseudogene)	MOXD2P MOXD2	Homo sapiens (Human)	499			dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]	extracellular space [GO:0005615]; secretory granule membrane [GO:0030667]	copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]	extracellular space [GO:0005615]; secretory granule membrane [GO:0030667]; copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]	
A6NHS7	reviewed	MANS4_HUMAN	MANSC domain-containing protein 4	MANSC4	Homo sapiens (Human)	340			epidermis development [GO:0008544]; epithelium development [GO:0060429]; extracellular matrix organization [GO:0030198]	plasma membrane [GO:0005886]	serine-type endopeptidase inhibitor activity [GO:0004867]	plasma membrane [GO:0005886]; serine-type endopeptidase inhibitor activity [GO:0004867]; epidermis development [GO:0008544]; epithelium development [GO:0060429]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A6NI03	reviewed	TR64B_HUMAN	Putative tripartite motif-containing protein 64B	TRIM64B	Homo sapiens (Human)	449			innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
A6NI72	reviewed	NCF1B_HUMAN	Putative neutrophil cytosol factor 1B (NCF-1B) (Putative SH3 and PX domain-containing protein 1B)	NCF1B SH3PXD1B	Homo sapiens (Human)	391	FUNCTION: May be required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000250}.		respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]	cytoplasm [GO:0005737]; NADPH oxidase complex [GO:0043020]	phosphatidylinositol binding [GO:0035091]; superoxide-generating NADPH oxidase activator activity [GO:0016176]	cytoplasm [GO:0005737]; NADPH oxidase complex [GO:0043020]; phosphatidylinositol binding [GO:0035091]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
A6NIE9	reviewed	PRS29_HUMAN	Putative serine protease 29 (EC 3.4.21.-) (Implantation serine proteinase 2-like protein) (ISP2-like protein)	PRSS29P ISP2	Homo sapiens (Human)	313			proteolysis [GO:0006508]	extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]	extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
A6NIJ9	reviewed	O6C70_HUMAN	Olfactory receptor 6C70	OR6C70	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NIM6	reviewed	S15A5_HUMAN	Solute carrier family 15 member 5	SLC15A5	Homo sapiens (Human)	579	FUNCTION: Proton oligopeptide cotransporter. {ECO:0000305}.		peptide transport [GO:0015833]; protein transport [GO:0015031]; transmembrane transport [GO:0055085]	membrane [GO:0016020]	symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]; peptide transport [GO:0015833]; protein transport [GO:0015031]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NIR3	reviewed	AGAP5_HUMAN	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 (AGAP-5) (Centaurin-gamma-like family member 2)	AGAP5 CTGLF2	Homo sapiens (Human)	686	FUNCTION: Putative GTPase-activating protein. {ECO:0000305}.	MISCELLANEOUS: Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.			GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	
A6NIZ1	reviewed	RP1BL_HUMAN	Ras-related protein Rap-1b-like protein (EC 3.6.5.2)	RAP1BL	Homo sapiens (Human)	184	FUNCTION: Probable GTP-binding protein with intrinsic GTPase activity. {ECO:0000250|UniProtKB:P61224}.		cellular response to cAMP [GO:0071320]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; Rap protein signal transduction [GO:0032486]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cellular response to cAMP [GO:0071320]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; Rap protein signal transduction [GO:0032486]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P61224}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P61224}. Note=May shuttle between plasma membrane and cytosol. {ECO:0000250|UniProtKB:P61224}.
A6NJG6	reviewed	ARGFX_HUMAN	Arginine-fifty homeobox	ARGFX	Homo sapiens (Human)	315	FUNCTION: Transcription factor that acts as activator. {ECO:0000269|PubMed:27412763}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A6NJL1	reviewed	ZSA5B_HUMAN	Zinc finger and SCAN domain-containing protein 5B	ZSCAN5B	Homo sapiens (Human)	495	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
A6NJV1	reviewed	CMI2C_HUMAN	Ciliary microtubule inner protein 2C	CIMIP2C C2orf70 FAM166C	Homo sapiens (Human)	201	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.			axonemal microtubule [GO:0005879]; nucleus [GO:0005634]		axonemal microtubule [GO:0005879]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
A6NJW4	reviewed	LRR3C_HUMAN	Leucine-rich repeat-containing protein 3C	LRRC3C	Homo sapiens (Human)	275				extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A6NJW9	reviewed	CD8B2_HUMAN	T-cell surface glycoprotein CD8 beta-2 chain (CD8b pseudogene)	CD8B2 CD8BP	Homo sapiens (Human)	210	FUNCTION: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing (By similarity). {ECO:0000250}.		adaptive immune response [GO:0002250]; regulation of immune response [GO:0050776]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	coreceptor activity [GO:0015026]; MHC class I protein binding [GO:0042288]	cell surface [GO:0009986]; plasma membrane [GO:0005886]; coreceptor activity [GO:0015026]; MHC class I protein binding [GO:0042288]; adaptive immune response [GO:0002250]; regulation of immune response [GO:0050776]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
A6NJY4	reviewed	T238L_HUMAN	Transmembrane protein 238-like (FOXA1-regulated conserved small protein) (FORCP)	TMEM238L FORCP	Homo sapiens (Human)	79	FUNCTION: May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity. {ECO:0000269|PubMed:33112233}.	MISCELLANEOUS: The TMEM238L transcript is unstable, and this instability is partly mediated through a conserved region containing AU-rich sequences in the TMEM238L 3'UTR (PubMed:35274990). Cancer cells lacking this conserved region display decreased proliferation and clonogenicity (PubMed:35274990). {ECO:0000269|PubMed:35274990, ECO:0000305|PubMed:35274990}.	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]	endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:33112233}; Multi-pass membrane protein {ECO:0000255}.
A6NJZ3	reviewed	O6C65_HUMAN	Olfactory receptor 6C65	OR6C65	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NJZ7	reviewed	RIM3C_HUMAN	RIMS-binding protein 3C (RIM-BP3.C) (RIMS-binding protein 3.3) (RIM-BP3.3)	RIMBP3C	Homo sapiens (Human)	1639	FUNCTION: Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}.		fertilization [GO:0009566]; spermatid development [GO:0007286]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]	benzodiazepine receptor binding [GO:0030156]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; benzodiazepine receptor binding [GO:0030156]; fertilization [GO:0009566]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q3V0F0}.
A6NK02	reviewed	TRI75_HUMAN	Tripartite motif-containing protein 75	TRIM75 TRIM75P	Homo sapiens (Human)	468	FUNCTION: May play a role in female meiosis. {ECO:0000250|UniProtKB:Q3UWZ0}.		female meiosis I [GO:0007144]; protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; spindle [GO:0005819]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; spindle [GO:0005819]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; female meiosis I [GO:0007144]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q3UWZ0}.
A6NK53	reviewed	ZN233_HUMAN	Zinc finger protein 233	ZNF233	Homo sapiens (Human)	670	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A6NK59	reviewed	ASB14_HUMAN	Ankyrin repeat and SOCS box protein 14 (ASB-14)	ASB14	Homo sapiens (Human)	587	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]		cytosol [GO:0005829]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	
A6NK75	reviewed	ZNF98_HUMAN	Zinc finger protein 98 (Zinc finger protein 739) (Zinc finger protein F7175)	ZNF98 ZNF739	Homo sapiens (Human)	572	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A6NKD2	reviewed	TSPY2_HUMAN	Testis-specific Y-encoded protein 2 (Testis-specific Y-encoded protein Q1)	TSPY2 TSPYQ1	Homo sapiens (Human)	308	FUNCTION: May be involved in sperm differentiation and proliferation. {ECO:0000250|UniProtKB:Q01534}.		cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01534}. Nucleus {ECO:0000250|UniProtKB:Q01534}.
A6NKD9	reviewed	CC85C_HUMAN	Coiled-coil domain-containing protein 85C	CCDC85C	Homo sapiens (Human)	419	FUNCTION: May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}.		cerebral cortex development [GO:0021987]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; bicellular tight junction [GO:0005923]		adherens junction [GO:0005912]; apical junction complex [GO:0043296]; bicellular tight junction [GO:0005923]; cerebral cortex development [GO:0021987]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:E9Q6B2}. Cell junction, adherens junction {ECO:0000269|PubMed:25009281}. Note=Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain. Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall. {ECO:0000250|UniProtKB:E9Q6B2}.
A6NKF2	reviewed	ARI3C_HUMAN	AT-rich interactive domain-containing protein 3C (ARID domain-containing protein 3C)	ARID3C	Homo sapiens (Human)	412			positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; membrane raft [GO:0045121]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]	cytoplasm [GO:0005737]; membrane raft [GO:0045121]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
A6NKG5	reviewed	RTL1_HUMAN	Retrotransposon-like protein 1 (Mammalian retrotransposon derived protein 1) (Paternally expressed gene 11 protein) (Retrotransposon-derived protein PEG11)	RTL1 MAR1 MART1 PEG11	Homo sapiens (Human)	1358	FUNCTION: Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta. {ECO:0000250}.	MISCELLANEOUS: Rtl1 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.; MISCELLANEOUS: RTL1 is an imprinted gene located in a cluster of imprinted genes on chromosome 14. It is expressed from the paternal chromosome and has an antisense transcript with full complementarity to RTL1, RTL1as, expressed from the maternal chromosome, which acts as a repressor for RTL1. Excessive RTL1 expression and decreased RTL1 expression are relevant to upd(14)pat-like and upd(14)mat-like phenotypes, respectively. Paternal and maternal uniparental disomy for chromosome 14 (upd(14)pat and upd(14)mat) cause distinct phenotypes; Upd(14)pat results in a unique phenotype characterized by facial abnormality, a small, bell-shaped thorax and abdominal wall defects, and upd(14)mat leads to pre- and postnatal growth failure and early onset of puberty.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NKK0	reviewed	OR5H1_HUMAN	Olfactory receptor 5H1 (HTPCRX14)	OR5H1	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NKQ9	reviewed	CGB1_HUMAN	Choriogonadotropin subunit beta variant 1	CGB1	Homo sapiens (Human)	187		MISCELLANEOUS: Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates. {ECO:0000269|PubMed:11861891}.	G protein-coupled receptor signaling pathway [GO:0007186]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	hormone activity [GO:0005179]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Secreted.
A6NKT7	reviewed	RGPD3_HUMAN	RanBP2-like and GRIP domain-containing protein 3	RGPD3 RGP3	Homo sapiens (Human)	1758		MISCELLANEOUS: One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.	NLS-bearing protein import into nucleus [GO:0006607]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]		cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; NLS-bearing protein import into nucleus [GO:0006607]	
A6NL08	reviewed	O6C75_HUMAN	Olfactory receptor 6C75	OR6C75	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NL26	reviewed	O5B21_HUMAN	Olfactory receptor 5B21	OR5B21	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
A6NL82	reviewed	CF144_HUMAN	Cilia- and flagella-associated protein 144 (Protein FAM183A)	CFAP144 FAM183A	Homo sapiens (Human)	134	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.			axonemal microtubule [GO:0005879]; ciliary base [GO:0097546]	microtubule binding [GO:0008017]	axonemal microtubule [GO:0005879]; ciliary base [GO:0097546]; microtubule binding [GO:0008017]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
A6NL99	reviewed	AQP73_HUMAN	Putative aquaporin-7-like protein 3	AQP7P3	Homo sapiens (Human)	342			glycerol transmembrane transport [GO:0015793]; water transport [GO:0006833]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	glycerol channel activity [GO:0015254]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; glycerol channel activity [GO:0015254]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250]; glycerol transmembrane transport [GO:0015793]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NLI5	reviewed	TR64C_HUMAN	Tripartite motif-containing protein 64C	TRIM64C	Homo sapiens (Human)	450			innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
A6NLP5	reviewed	TTC36_HUMAN	Tetratricopeptide repeat protein 36 (TPR repeat protein 36) (HSP70-binding protein 21)	TTC36 HBP21	Homo sapiens (Human)	189			central nervous system neuron development [GO:0021954]; cilium assembly [GO:0060271]; memory [GO:0007613]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein polyubiquitination [GO:1902915]; tyrosine metabolic process [GO:0006570]; visual learning [GO:0008542]			central nervous system neuron development [GO:0021954]; cilium assembly [GO:0060271]; memory [GO:0007613]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein polyubiquitination [GO:1902915]; tyrosine metabolic process [GO:0006570]; visual learning [GO:0008542]	
A6NLW8	reviewed	DUXA_HUMAN	Double homeobox protein A	DUXA	Homo sapiens (Human)	204	FUNCTION: Transcription factor that acts as repressor. {ECO:0000269|PubMed:27412763}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A6NM03	reviewed	O2AG2_HUMAN	Olfactory receptor 2AG2	OR2AG2 OR2AG2P	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NM10	reviewed	AQ12B_HUMAN	Aquaporin-12B (AQP-12B)	AQP12B	Homo sapiens (Human)	295	FUNCTION: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. {ECO:0000250}.			cytoplasm [GO:0005737]; membrane [GO:0016020]	channel activity [GO:0015267]; water channel activity [GO:0015250]	cytoplasm [GO:0005737]; membrane [GO:0016020]; channel activity [GO:0015267]; water channel activity [GO:0015250]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NM11	reviewed	L37A2_HUMAN	Leucine-rich repeat-containing protein 37A2	LRRC37A2	Homo sapiens (Human)	1700				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A6NM28	reviewed	ZFP92_HUMAN	Zinc finger protein 92 homolog (Zfp-92)	ZFP92	Homo sapiens (Human)	416	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
A6NM43	reviewed	TCPQL_HUMAN	Putative T-complex protein 1 subunit theta-like 1	CCT8L1P CCT8L1	Homo sapiens (Human)	557	FUNCTION: Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis. {ECO:0000250|UniProtKB:P40227}.		protein folding [GO:0006457]	chaperonin-containing T-complex [GO:0005832]	ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082]	chaperonin-containing T-complex [GO:0005832]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40227}.
A6NM45	reviewed	CLD24_HUMAN	Putative claudin-24 (Claudin-21)	CLDN24 CLDN21	Homo sapiens (Human)	220	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.		bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]	bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
A6NM76	reviewed	O6C76_HUMAN	Olfactory receptor 6C76	OR6C76	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NMS3	reviewed	OR5K4_HUMAN	Olfactory receptor 5K4	OR5K4	Homo sapiens (Human)	321	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NMS7	reviewed	L37A1_HUMAN	Leucine-rich repeat-containing protein 37A	LRRC37A LRRC37A1	Homo sapiens (Human)	1700				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A6NMT0	reviewed	DBX1_HUMAN	Homeobox protein DBX1 (Developing brain homeobox protein 1)	DBX1	Homo sapiens (Human)	343	FUNCTION: Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity). {ECO:0000250}.		cell differentiation in spinal cord [GO:0021515]; regulation of transcription by RNA polymerase II [GO:0006357]; ventral spinal cord interneuron specification [GO:0021521]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; cell differentiation in spinal cord [GO:0021515]; regulation of transcription by RNA polymerase II [GO:0006357]; ventral spinal cord interneuron specification [GO:0021521]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A6NMU1	reviewed	O52A4_HUMAN	Olfactory receptor 52A4	OR52A4P OR52A4	Homo sapiens (Human)	304	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NMX2	reviewed	I4E1B_HUMAN	Eukaryotic translation initiation factor 4E type 1B	EIF4E1B	Homo sapiens (Human)	242	FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure. {ECO:0000250}.			eukaryotic translation initiation factor 4F complex [GO:0016281]; mRNA cap binding complex [GO:0005845]	RNA 7-methylguanosine cap binding [GO:0000340]; translation initiation factor activity [GO:0003743]	eukaryotic translation initiation factor 4F complex [GO:0016281]; mRNA cap binding complex [GO:0005845]; RNA 7-methylguanosine cap binding [GO:0000340]; translation initiation factor activity [GO:0003743]	
A6NMZ5	reviewed	O4C45_HUMAN	Olfactory receptor 4C45	OR4C45	Homo sapiens (Human)	306	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
A6NN14	reviewed	ZN729_HUMAN	Zinc finger protein 729	ZNF729	Homo sapiens (Human)	1252	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A6NN73	reviewed	GOG8C_HUMAN	Golgin subfamily A member 8C	GOLGA8CP GOLGA8C	Homo sapiens (Human)	597			Golgi organization [GO:0007030]; spindle assembly [GO:0051225]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]; spindle assembly [GO:0051225]	
A6NN92	reviewed	CXE1_HUMAN	Putative gap junction epsilon-1 protein (Connexin-23) (Cx23)	GJE1	Homo sapiens (Human)	205	FUNCTION: Mediates calcium-independent ATP release, suggesting activity as a hemichannel. Does not form functional gap junctions. {ECO:0000250|UniProtKB:Q9CX92}.		cell morphogenesis [GO:0000902]; cell-cell signaling [GO:0007267]; lens development in camera-type eye [GO:0002088]; organ growth [GO:0035265]	connexin complex [GO:0005922]	gap junction channel activity [GO:0005243]	connexin complex [GO:0005922]; gap junction channel activity [GO:0005243]; cell morphogenesis [GO:0000902]; cell-cell signaling [GO:0007267]; lens development in camera-type eye [GO:0002088]; organ growth [GO:0035265]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
A6NNF4	reviewed	ZN726_HUMAN	Zinc finger protein 726	ZNF726	Homo sapiens (Human)	616	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
A6NNM3	reviewed	RIM3B_HUMAN	RIMS-binding protein 3B (RIM-BP3.B) (RIMS-binding protein 3.2) (RIM-BP3.2)	RIMBP3B	Homo sapiens (Human)	1639	FUNCTION: Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}.		fertilization [GO:0009566]; spermatid development [GO:0007286]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]	benzodiazepine receptor binding [GO:0030156]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; benzodiazepine receptor binding [GO:0030156]; fertilization [GO:0009566]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q3V0F0}.
A6NNP5	reviewed	CC169_HUMAN	Coiled-coil domain-containing protein 169	CCDC169 C13orf38	Homo sapiens (Human)	214							
A6NP11	reviewed	ZN716_HUMAN	Zinc finger protein 716	ZNF716	Homo sapiens (Human)	495	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A6NP61	reviewed	ZAR1L_HUMAN	Protein ZAR1-like (Zygote arrest protein 1-like)	ZAR1L	Homo sapiens (Human)	321	FUNCTION: mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (By similarity). Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity). Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation (By similarity). {ECO:0000250|UniProtKB:C3VD30, ECO:0000250|UniProtKB:Q80SU3}.		negative regulation of translation [GO:0017148]; oocyte maturation [GO:0001556]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; intracellular non-membrane-bounded organelle [GO:0043232]	metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; intracellular non-membrane-bounded organelle [GO:0043232]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; negative regulation of translation [GO:0017148]; oocyte maturation [GO:0001556]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:C3VD30}.
A6PVL3	reviewed	KNCN_HUMAN	Kinocilin	KNCN	Homo sapiens (Human)	124	FUNCTION: May play a role in stabilizing dense microtubular networks or in vesicular trafficking. {ECO:0000250}.			apical plasma membrane [GO:0016324]; ciliary basal body [GO:0036064]; cuticular plate [GO:0032437]; kinocilium [GO:0060091]; neuronal cell body [GO:0043025]		apical plasma membrane [GO:0016324]; ciliary basal body [GO:0036064]; cuticular plate [GO:0032437]; kinocilium [GO:0060091]; neuronal cell body [GO:0043025]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6PVS8	reviewed	LRIQ3_HUMAN	Leucine-rich repeat and IQ domain-containing protein 3 (Leucine-rich repeat-containing protein 44)	LRRIQ3 LRRC44	Homo sapiens (Human)	624							
A6QL64	reviewed	AN36A_HUMAN	Ankyrin repeat domain-containing protein 36A	ANKRD36 ANKRD36A KIAA1641 UNQ2430/PRO499	Homo sapiens (Human)	1915							
A7E2U8	reviewed	CFA96_HUMAN	Cilia-and flagella-associated protein 96	CFAP96 C4orf47	Homo sapiens (Human)	309				9+0 non-motile cilium [GO:0097731]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]		9+0 non-motile cilium [GO:0097731]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25074808}.
A8K0R7	reviewed	ZN839_HUMAN	Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50)	ZNF839 C14orf131	Homo sapiens (Human)	811					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
A8K0S8	reviewed	ME3L2_HUMAN	Putative homeobox protein Meis3-like 2	MEIS3P2	Homo sapiens (Human)	358			animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A8K5M9	reviewed	CO062_HUMAN	Uncharacterized protein C15orf62, mitochondrial	C15orf62	Homo sapiens (Human)	175			positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; small GTPase binding [GO:0031267]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
A8MPS7	reviewed	YDJC_HUMAN	Carbohydrate deacetylase (EC 3.5.1.-)	YDJC	Homo sapiens (Human)	323	FUNCTION: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. {ECO:0000250|UniProtKB:Q53WD3}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	carbohydrate metabolic process [GO:0005975]		deacetylase activity [GO:0019213]; magnesium ion binding [GO:0000287]	deacetylase activity [GO:0019213]; magnesium ion binding [GO:0000287]; carbohydrate metabolic process [GO:0005975]	
A8MPX8	reviewed	PP2D1_HUMAN	Protein phosphatase 2C-like domain-containing protein 1	PP2D1 C3orf48	Homo sapiens (Human)	630					protein serine/threonine phosphatase activity [GO:0004722]	protein serine/threonine phosphatase activity [GO:0004722]	
A8MT70	reviewed	ZBBX_HUMAN	Zinc finger B-box domain-containing protein 1	ZBBX	Homo sapiens (Human)	800					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
A8MTI9	reviewed	PRS47_HUMAN	Putative serine protease 47 (EC 3.4.21.-) (Serine protease 47, pseudogene)	PRSS47P PRSS47	Homo sapiens (Human)	375			proteolysis [GO:0006508]	extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]	extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A8MTL9	reviewed	HMSD_HUMAN	Serpin-like protein HMSD (Minor histocompatibility protein HMSD) (Minor histocompatibility serpin domain-containing protein)	HMSD	Homo sapiens (Human)	139	FUNCTION: Putative serine protease inhibitor. {ECO:0000250}.		activation of immune response [GO:0002253]	extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; activation of immune response [GO:0002253]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A8MTY7	reviewed	KRA97_HUMAN	Keratin-associated protein 9-7 (Keratin-associated protein 9-like 1)	KRTAP9-7 KAP9.7 KRTAP9.7 KRTAP9L1	Homo sapiens (Human)	169	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
A8MUH7	reviewed	PDZ1P_HUMAN	Putative PDZ domain-containing protein PDZK1P1 (PDZ domain-containing 1 pseudogene 1) (PDZ domain-containing 1 pseudogene 2)	PDZK1P1 PDZK1P2	Homo sapiens (Human)	402			protein localization to plasma membrane [GO:0072659]	apical plasma membrane [GO:0016324]	protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]	apical plasma membrane [GO:0016324]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; protein localization to plasma membrane [GO:0072659]	
A8MUM7	reviewed	LEG16_HUMAN	Galectin-16	LGALS16	Homo sapiens (Human)	142	FUNCTION: Binds lactose with high affinity. Strong inducer of T-cell apoptosis. {ECO:0000269|PubMed:19497882}.		apoptotic process [GO:0006915]; positive regulation of T cell apoptotic process [GO:0070234]		lactose binding [GO:0030395]	lactose binding [GO:0030395]; apoptotic process [GO:0006915]; positive regulation of T cell apoptotic process [GO:0070234]	
A8MUV8	reviewed	ZN727_HUMAN	Putative zinc finger protein 727 (Zinc finger protein 727 pseudogene)	ZNF727 ZNF727P	Homo sapiens (Human)	499	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
A8MV23	reviewed	SERP3_HUMAN	Serpin E3	SERPINE3	Homo sapiens (Human)	424	FUNCTION: Probable serine protease inhibitor. {ECO:0000250}.			extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A8MVA2	reviewed	KRA96_HUMAN	Keratin-associated protein 9-6 (Keratin-associated protein 9-like 2)	KRTAP9-6 KAP9.6 KRTAP9.6 KRTAP9L2	Homo sapiens (Human)	160	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
A8MVS5	reviewed	HIDE1_HUMAN	Protein HIDE1	HIDE1 C19orf38	Homo sapiens (Human)	230				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
A8MVU1	reviewed	NCF1C_HUMAN	Putative neutrophil cytosol factor 1C (NCF-1C) (Putative SH3 and PX domain-containing protein 1C)	NCF1C SH3PXD1C	Homo sapiens (Human)	366	FUNCTION: May be required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000250}.		respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]	cytoplasm [GO:0005737]; NADPH oxidase complex [GO:0043020]	phosphatidylinositol binding [GO:0035091]; superoxide-generating NADPH oxidase activator activity [GO:0016176]	cytoplasm [GO:0005737]; NADPH oxidase complex [GO:0043020]; phosphatidylinositol binding [GO:0035091]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
A8MVW0	reviewed	F1712_HUMAN	Protein FAM171A2	FAM171A2	Homo sapiens (Human)	826				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A8MVZ5	reviewed	BTNLA_HUMAN	Putative butyrophilin-like protein 10 pseudogene	BTNL10P BTNL10	Homo sapiens (Human)	291			regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; signaling receptor binding [GO:0005102]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A8MWA4	reviewed	Z705E_HUMAN	Putative zinc finger protein 705EP (zinc finger protein 705E pseudogene)	ZNF705EP ZNF705E	Homo sapiens (Human)	300	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A8MWD9	reviewed	RUXGL_HUMAN	Putative small nuclear ribonucleoprotein G-like protein 15	SNRPGP15	Homo sapiens (Human)	76	FUNCTION: Associated with snRNP U1, U2, U4/U6 and U5. {ECO:0000250}.		mRNA splicing, via spliceosome [GO:0000398]; spliceosomal snRNP assembly [GO:0000387]	catalytic step 2 spliceosome [GO:0071013]; P granule [GO:0043186]; precatalytic spliceosome [GO:0071011]; SMN-Sm protein complex [GO:0034719]; spliceosomal tri-snRNP complex [GO:0097526]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U5 snRNP [GO:0005682]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; P granule [GO:0043186]; precatalytic spliceosome [GO:0071011]; SMN-Sm protein complex [GO:0034719]; spliceosomal tri-snRNP complex [GO:0097526]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U5 snRNP [GO:0005682]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal snRNP assembly [GO:0000387]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
A8MWK0	reviewed	FS2P1_HUMAN	Putative fatty acid desaturase 2-like protein FADS2B (Fatty acid desaturase 2 pseudogene 1) (Fatty acid desaturase 2B, pseudogene)	FADS2B FADS2P1	Homo sapiens (Human)	482			lipid metabolic process [GO:0006629]; unsaturated fatty acid biosynthetic process [GO:0006636]	endoplasmic reticulum membrane [GO:0005789]	metal ion binding [GO:0046872]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]	endoplasmic reticulum membrane [GO:0005789]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]; lipid metabolic process [GO:0006629]; unsaturated fatty acid biosynthetic process [GO:0006636]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O95864}; Multi-pass membrane protein {ECO:0000255}.
A8MX76	reviewed	CAN14_HUMAN	Calpain-14 (EC 3.4.22.-) (Calcium-activated neutral proteinase 14) (CANP 14)	CAPN14	Homo sapiens (Human)	684	FUNCTION: Calcium-regulated non-lysosomal thiol-protease. {ECO:0000250}.		proteolysis [GO:0006508]	cytoplasm [GO:0005737]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; proteolysis [GO:0006508]	
A8MXE2	reviewed	B3GT9_HUMAN	Beta-1,3-galactosyltransferase 9 (EC 2.4.1.-) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 10)	B3GALT9 B3GNT10	Homo sapiens (Human)	369	FUNCTION: Putative glycosyltransferase that could catalyze the transfer of galactose residues from UDP-alpha-D-galactose. {ECO:0000305}.		protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	hexosyltransferase activity [GO:0016758]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; hexosyltransferase activity [GO:0016758]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
A8MXU0	reviewed	DB108_HUMAN	Putative beta-defensin 108A (Defensin, beta 108A) (Defensin, beta 108C) (Putative beta-defensin 108B pseudogene 1/2)	DEFB108A DEFB108P1; DEFB108C DEFB108P2	Homo sapiens (Human)	73	FUNCTION: Has antibacterial activity. {ECO:0000305}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
A8MXY4	reviewed	ZNF99_HUMAN	Zinc finger protein 99	ZNF99 C19orf9	Homo sapiens (Human)	864	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A8MXZ3	reviewed	KRA91_HUMAN	Keratin-associated protein 9-1 (Keratin-associated protein 9-like 3)	KRTAP9-1 KAP9.1 KRTAP9.1 KRTAP9L3	Homo sapiens (Human)	250	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
A8MYV0	reviewed	DCD2C_HUMAN	Doublecortin domain-containing protein 2C	DCDC2C	Homo sapiens (Human)	364			intracellular signal transduction [GO:0035556]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; sperm flagellum [GO:0036126]		cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; sperm flagellum [GO:0036126]; intracellular signal transduction [GO:0035556]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:28395323}. Cytoplasm {ECO:0000269|PubMed:28395323}. Note=Detected along the length of the sperm flagellum and in the cytoplasm of the germ cells. {ECO:0000269|PubMed:28395323}.
A8MYZ6	reviewed	FOXO6_HUMAN	Forkhead box protein O6	FOXO6	Homo sapiens (Human)	492	FUNCTION: Transcriptional activator. {ECO:0000250}.		memory [GO:0007613]; positive regulation of dendritic spine development [GO:0060999]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; memory [GO:0007613]; positive regulation of dendritic spine development [GO:0060999]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}. Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity). {ECO:0000250}.
A8MZ26	reviewed	EFCB9_HUMAN	EF-hand calcium-binding domain-containing protein 9	EFCAB9	Homo sapiens (Human)	197	FUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. pH-dependent Ca(2+) sensor required to activate the CatSper channel. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel. {ECO:0000250|UniProtKB:Q9DAM2}.		flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]	CatSper complex [GO:0036128]; cytoplasm [GO:0005737]; sperm principal piece [GO:0097228]	calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]	CatSper complex [GO:0036128]; cytoplasm [GO:0005737]; sperm principal piece [GO:0097228]; calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9DAM2}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9DAM2}. Note=Localizes to the principal piece of the sperm tail. {ECO:0000250|UniProtKB:Q9DAM2}.
B1AJZ9	reviewed	FHAD1_HUMAN	Forkhead-associated domain-containing protein 1 (FHA domain-containing protein 1)	FHAD1 KIAA1937	Homo sapiens (Human)	1412							
B1AKI9	reviewed	ISM1_HUMAN	Isthmin-1	ISM1 C20orf82 ISM	Homo sapiens (Human)	464	FUNCTION: Acts as an angiogenesis inhibitor. {ECO:0000250|UniProtKB:A2ATD1}.		negative regulation of angiogenesis [GO:0016525]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; negative regulation of angiogenesis [GO:0016525]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
B1APH4	reviewed	ZN487_HUMAN	Putative zinc finger protein 487 (KRAB domain only protein 1)	ZNF487 KRBO1 ZNF487P	Homo sapiens (Human)	448	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
B2CW77	reviewed	KILIN_HUMAN	Killin	KLLN	Homo sapiens (Human)	178	FUNCTION: DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA. {ECO:0000269|PubMed:18385383}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18385383}.
B2RC85	reviewed	R10B2_HUMAN	Radial spoke head 10 homolog B2	RSPH10B2	Homo sapiens (Human)	870	FUNCTION: May function as part of the axonemal radial spoke complex 3 (RS3). Radial spoke complexes are important for ciliary motility. {ECO:0000250|UniProtKB:E9PYQ0}.			cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]		cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:E9PYQ0}.
B2RN74	reviewed	O11HC_HUMAN	Olfactory receptor 11H12	OR11H12	Homo sapiens (Human)	326	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
B2RPK0	reviewed	HGB1A_HUMAN	Putative high mobility group protein B1-like 1 (High mobility group protein B1 pseudogene 1) (Putative high mobility group protein 1-like 1) (HMG-1L1)	HMGB1P1 HMG1L1 HMGB1L1	Homo sapiens (Human)	211	FUNCTION: Binds preferentially single-stranded DNA and unwinds double-stranded DNA. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromosome [GO:0005694]; nucleus [GO:0005634]	DNA binding, bending [GO:0008301]	chromosome [GO:0005694]; nucleus [GO:0005634]; DNA binding, bending [GO:0008301]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Chromosome {ECO:0000250}.
B2RXH4	reviewed	BTBDI_HUMAN	BTB/POZ domain-containing protein 18	BTBD18	Homo sapiens (Human)	712	FUNCTION: Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene. {ECO:0000250|UniProtKB:A0A0A6YY25}.		cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; piRNA transcription [GO:0140541]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]		nucleus [GO:0005634]; cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; piRNA transcription [GO:0140541]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A0A0A6YY25}.
B3SHH9	reviewed	TM114_HUMAN	Transmembrane protein 114	TMEM114	Homo sapiens (Human)	223				apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]		apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255}.
B4DU55	reviewed	ZN879_HUMAN	Zinc finger protein 879	ZNF879	Homo sapiens (Human)	563	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
B4DYI2	reviewed	S31C2_HUMAN	Putative spermatogenesis-associated protein 31C2 (Protein FAM75C2)	SPATA31C2 FAM75C2	Homo sapiens (Human)	1134	FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
B5ME19	reviewed	EIFCL_HUMAN	Eukaryotic translation initiation factor 3 subunit C-like protein	EIF3CL	Homo sapiens (Human)	914	FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}.		formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]; formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99613}.
B7Z8K6	reviewed	TRDC_HUMAN	T cell receptor delta constant	TRDC	Homo sapiens (Human)	153	FUNCTION: Constant region of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]; gamma-delta T cell activation [GO:0046629]; T cell receptor signaling pathway [GO:0050852]	gamma-delta T cell receptor complex [GO:0042106]; plasma membrane [GO:0005886]		gamma-delta T cell receptor complex [GO:0042106]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; gamma-delta T cell activation [GO:0046629]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
B7ZAP0	reviewed	RBG10_HUMAN	Rab GTPase-activating protein 1-like, isoform 10	RABGAP1L HHL KIAA0471	Homo sapiens (Human)	253							
B7ZC32	reviewed	KIF28_HUMAN	Kinesin-like protein KIF28P (Kinesin-like protein 6)	KIF28P KLP6	Homo sapiens (Human)	967	FUNCTION: Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells. {ECO:0000250}.		cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384]	kinesin complex [GO:0005871]; microtubule [GO:0005874]; mitochondrial membrane [GO:0031966]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	kinesin complex [GO:0005871]; microtubule [GO:0005874]; mitochondrial membrane [GO:0031966]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
B9A064	reviewed	IGLL5_HUMAN	Immunoglobulin lambda-like polypeptide 5 (G lambda-1) (Germline immunoglobulin lambda 1)	IGLL5	Homo sapiens (Human)	214		MISCELLANEOUS: Located within the immunoglobulin lambda locus, but does not require somatic rearrangement for expression.	immunoglobulin mediated immune response [GO:0016064]	extracellular exosome [GO:0070062]; IgG immunoglobulin complex [GO:0071735]	antigen binding [GO:0003823]	extracellular exosome [GO:0070062]; IgG immunoglobulin complex [GO:0071735]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
B9EJG8	reviewed	T150C_HUMAN	Transmembrane protein 150C	TMEM150C	Homo sapiens (Human)	249	FUNCTION: Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception. {ECO:0000250|UniProtKB:Q8C8S3}.	MISCELLANEOUS: Tentonin comes from the Greek 'tentono' meaning to stretch. {ECO:0000250|UniProtKB:Q8C8S3}.	cellular response to mechanical stimulus [GO:0071260]; proprioception [GO:0019230]	lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	mechanosensitive monoatomic ion channel activity [GO:0008381]	lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; mechanosensitive monoatomic ion channel activity [GO:0008381]; cellular response to mechanical stimulus [GO:0071260]; proprioception [GO:0019230]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25608530}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000305|PubMed:25608530}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes at the plasma membrane. A portion co-localizes with LAMP1 lysosomal marker (PubMed:25608530). {ECO:0000269|PubMed:25608530}.
C0HLV8	reviewed	MP31_HUMAN	PTEN upstream open reading frame MP31 (Micropeptide 31)		Homo sapiens (Human)	31	FUNCTION: Inhibits lactate dehydrogenase (LDH)-mediated conversion of lactate to pyruvate in mitochondria by competing with mitochondrial LDH for binding to NAD(+) (PubMed:33406399). Also inhibits cellular lactate utilization (PubMed:33406399). {ECO:0000269|PubMed:33406399}.		lactate oxidation [GO:0019516]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; lactate oxidation [GO:0019516]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:33406399}.
C0HLZ6	reviewed	HAS3P_HUMAN	HOXB-AS3 peptide	HOXB-AS3	Homo sapiens (Human)	53	FUNCTION: Blocks the binding of HNRNPA1 to the intronic sequences flanking exon 9 of the PKM gene by competitively binding to the HNRNPA1 RGG-box motif (PubMed:28985503). This inhibits inclusion of exon 9 and promotes inclusion of exon 10, suppressing formation of the PKM M2 isoform and promoting production of the M1 isoform (PubMed:28985503). Also suppresses HNRNPA1-mediated processing of microRNA 18a (miR-18a) (PubMed:28985503). Promotes MYC stability through interaction with IGF2BP2 (PubMed:34457052). {ECO:0000269|PubMed:28985503, ECO:0000269|PubMed:34457052}.	MISCELLANEOUS: By blocking HNRNPA1-dependent PKM splicing, inhibits colon cancer cell aerobic glycolysis and suppresses colon cancer cell growth, colony formation, migration and invasion (PubMed:28985503). Promotes the proliferation and viability of oral squamous cell carcinoma cells (PubMed:34457052). {ECO:0000269|PubMed:28985503, ECO:0000269|PubMed:34457052}.	mRNA processing [GO:0006397]; negative regulation of pre-miRNA processing [GO:2000632]; protein stabilization [GO:0050821]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]			mRNA processing [GO:0006397]; negative regulation of pre-miRNA processing [GO:2000632]; protein stabilization [GO:0050821]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	
C0HM01	reviewed	RBRP_HUMAN	Putative RNA-binding regulatory peptide (RBRP) (Septin 14 pseudogene 20)	SEPTIN14P20 C20orf69 LINC00266-1	Homo sapiens (Human)	71	FUNCTION: Enhances binding of IGF2BP1 to N6-methyladenosine (m6A)-containing mRNAs, thereby contributing to increased mRNA stability (PubMed:32245947). Also increases the interaction of IGF2BP1 with RNA stabilizers ELAVL1/HUR, MATR3 and PABPC1, and increases the interaction of RNA stabilizers ELAVL1/HUR, MATR3 and PABPC1 with m6A-containing mRNAs (PubMed:32245947). Contributes to MYC stability by enhancing binding of IGF2BP1 to m6A-containing MYC mRNAs and increasing recruitment of RNA stabilizing proteins to m6A-containing MYC mRNAs (PubMed:32245947). {ECO:0000269|PubMed:32245947}.	MISCELLANEOUS: Promotes colon cancer cell growth, colony formation, migration and invasion through enhanced stability of MYC (PubMed:32245947). Expressed in colorectal, breast, ovarian and nasopharyngeal cancer cells (PubMed:32245947). Higher levels are found in colon cancer cells than in adjacent nontumor tissue (PubMed:32245947). {ECO:0000269|PubMed:32245947}.	mRNA stabilization [GO:0048255]; positive regulation of mRNA binding [GO:1902416]			mRNA stabilization [GO:0048255]; positive regulation of mRNA binding [GO:1902416]	
C0HM83	reviewed	SHMOS_HUMAN	Protein SHMOOSE (Small human mitochondrial ORF over serine tRNA)		Homo sapiens (Human)	58	FUNCTION: Increases neural cell metabolic activity and mitochondrial oxygen consumption rate. {ECO:0000269|PubMed:36127429}.	MISCELLANEOUS: Shows elevated expression in Alzheimer disease patient brains and protects against cell death in vitro in neuronal cells stressed with oligomerized amyloid-beta protein 42. {ECO:0000269|PubMed:36127429}.; MISCELLANEOUS: Intracerebroventricular administration to the rat brain for 24 hours results in significant alterations to the hypothalamus transcriptome and, to a lesser extent, the hippocampus transcriptome. {ECO:0000269|PubMed:36127429}.					SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:36127429}. Nucleus {ECO:0000269|PubMed:36127429}. Note=Detected in neuronal mitochondria and nuclei. {ECO:0000269|PubMed:36127429}.
C9J069	reviewed	AJM1_HUMAN	Apical junction component 1 homolog	AJM1 C9orf172	Homo sapiens (Human)	976	FUNCTION: May be involved in the control of adherens junction integrity. {ECO:0000250|UniProtKB:A0A1C3NSL9}.		cell-cell junction organization [GO:0045216]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cilium [GO:0005929]; plasma membrane [GO:0005886]		adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cilium [GO:0005929]; plasma membrane [GO:0005886]; cell-cell junction organization [GO:0045216]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:A0A1C3NSL9}. Cell projection, cilium {ECO:0000250|UniProtKB:A0A1C3NSL9}. Cell junction, adherens junction {ECO:0000250|UniProtKB:A0A1C3NSL9}.
C9J1S8	reviewed	TR49D_HUMAN	Tripartite motif-containing protein 49D (Tripartite motif-containing protein 49-like protein) (Tripartite motif-containing protein 49D1) (Tripartite motif-containing protein 49D2)	TRIM49D1 TRIM49L TRIM49L1; TRIM49D2 TRIM49D2P	Homo sapiens (Human)	452			innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
C9J2P7	reviewed	U17LF_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 15 (EC 3.4.19.12)	USP17L15	Homo sapiens (Human)	553	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
C9J798	reviewed	RAS4B_HUMAN	Ras GTPase-activating protein 4B	RASA4B	Homo sapiens (Human)	803	FUNCTION: Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway. {ECO:0000250|UniProtKB:O43374}.		cellular response to calcium ion [GO:0071277]; intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; cellular response to calcium ion [GO:0071277]; intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O43374}. Cell membrane {ECO:0000250|UniProtKB:O43374}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43374}.
C9JCN9	reviewed	HSBPL_HUMAN	Heat shock factor-binding protein 1-like protein 1	HSBP1L1	Homo sapiens (Human)	74			cellular heat acclimation [GO:0070370]	cytosol [GO:0005829]; nucleus [GO:0005634]	transcription corepressor activity [GO:0003714]	cytosol [GO:0005829]; nucleus [GO:0005634]; transcription corepressor activity [GO:0003714]; cellular heat acclimation [GO:0070370]	
C9JDP6	reviewed	CLD25_HUMAN	Putative claudin-25	CLDN25	Homo sapiens (Human)	229	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.		bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]	bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]; tight junction [GO:0070160]	structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]; tight junction [GO:0070160]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
C9JH25	reviewed	PRRT4_HUMAN	Proline-rich transmembrane protein 4	PRRT4	Homo sapiens (Human)	899				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
C9JJH3	reviewed	U17LA_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 10 (EC 3.4.19.12)	USP17L10	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
C9JLJ4	reviewed	U17LD_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 13 (EC 3.4.19.12)	USP17L13	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
C9JLR9	reviewed	ZFTA_HUMAN	Zinc finger translocation-associated protein (ZFTA)	ZFTA C11orf95	Homo sapiens (Human)	678			negative regulation of DNA-templated transcription [GO:0045892]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of DNA-templated transcription [GO:0045892]	
C9JPN9	reviewed	UL17C_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 12 (EC 3.4.19.12)	USP17L12	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
C9JQL5	reviewed	DSA2D_HUMAN	Putative dispanin subfamily A member 2d (DSPA2d)		Homo sapiens (Human)	133			defense response to virus [GO:0051607]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral genome replication [GO:0045071]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; type I interferon-mediated signaling pathway [GO:0060337]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; defense response to virus [GO:0051607]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral genome replication [GO:0045071]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; type I interferon-mediated signaling pathway [GO:0060337]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
C9JSJ3	reviewed	MEIOS_HUMAN	Meiosis initiator protein (Basic helix-loop-helix and HMG box domain-containing protein 1)	MEIOSIN BHMG1	Homo sapiens (Human)	638	FUNCTION: Gatekeeper of meiotic initiation in both male and female germ cells. In complex with STRA8, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. Temporal expression of MEIOSIN is required for meiotic entry decision. {ECO:0000250|UniProtKB:A0A5K7RLP0}.		activation of meiosis [GO:0090427]; cellular response to retinoic acid [GO:0071300]; meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]	DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]	nucleus [GO:0005634]; DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]; activation of meiosis [GO:0090427]; cellular response to retinoic acid [GO:0071300]; meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A0A5K7RLP0}.
C9JUS6	reviewed	ADM5_HUMAN	Putative adrenomedullin-5-like protein	ADM5 C19orf76	Homo sapiens (Human)	153	FUNCTION: Probable non-functional remnant of adrenomedullin-5. {ECO:0000269|PubMed:18434369}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; positive regulation of heart rate [GO:0010460]; regulation of systemic arterial blood pressure [GO:0003073]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; positive regulation of heart rate [GO:0010460]; regulation of systemic arterial blood pressure [GO:0003073]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
C9JVI0	reviewed	U17LB_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 11 (EC 3.4.19.12)	USP17L11	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
C9JXX5	reviewed	FREY_HUMAN	Protein Frey 1 (Frey regulator of sperm-oocyte fusion 1) (FREY1)	FREY1 C11orf94 FREY	Homo sapiens (Human)	98	FUNCTION: Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome. Through the interaction with SPPL2C, inhibits its intramembrane protease activity directly accessing the catalytic center of an I-CLiP. {ECO:0000250|UniProtKB:Q8CF31}.		fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; sperm-egg recognition [GO:0035036]	endoplasmic reticulum membrane [GO:0005789]	protein-macromolecule adaptor activity [GO:0030674]	endoplasmic reticulum membrane [GO:0005789]; protein-macromolecule adaptor activity [GO:0030674]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; sperm-egg recognition [GO:0035036]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8CF31}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8CF31}.
D6R901	reviewed	U17LL_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 21 (EC 3.4.19.12)	USP17L21	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
D6R9N7	reviewed	U17LI_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 18 (EC 3.4.19.12)	USP17L18	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
D6RA61	reviewed	U17LM_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 22 (EC 3.4.19.12)	USP17L22	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
D6RBQ6	reviewed	U17LH_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 17 (EC 3.4.19.12)	USP17L17	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
D6RCP7	reviewed	U17LJ_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 19 (EC 3.4.19.12)	USP17L19	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
D6RIA3	reviewed	CD054_HUMAN	Uncharacterized protein C4orf54 (Familial obliterative portal venopathy)	C4orf54 FOPV	Homo sapiens (Human)	1793							
D6RJB6	reviewed	U17LK_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 20 (EC 3.4.19.12)	USP17L20	Homo sapiens (Human)	530	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.		proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
E2RYF6	reviewed	MUC22_HUMAN	Mucin-22 (Panbronchiolitis-related mucin-like protein 1)	MUC22 G4 PBMUCL1	Homo sapiens (Human)	1773				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
E2RYF7	reviewed	PBMU2_HUMAN	Protein PBMUCL2 (HLA complex group 22) (Panbronchiolitis-related mucin-like protein 2)	HCG22 G2 PBMUCL2	Homo sapiens (Human)	251				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
E7ETH6	reviewed	Z587B_HUMAN	Zinc finger protein 587B	ZNF587B	Homo sapiens (Human)	402	FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
E9PB15	reviewed	PTG3L_HUMAN	Putative protein PTGES3L (Prostaglandin E synthase 3-like)	PTGES3L	Homo sapiens (Human)	166			chaperone-mediated protein complex assembly [GO:0051131]; protein folding [GO:0006457]	cytosol [GO:0005829]; nucleus [GO:0005634]	Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087]	cytosol [GO:0005829]; nucleus [GO:0005634]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087]; chaperone-mediated protein complex assembly [GO:0051131]; protein folding [GO:0006457]	
E9PQ53	reviewed	NDUCR_HUMAN	NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2 (NDUFC2-KCTD14 readthrough transcript protein)	NDUFC2-KCTD14	Homo sapiens (Human)	114	FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: Based on a readthrough transcript which may produce a NDUFC2-KCTD14 fusion protein.	mitochondrial electron transport, NADH to ubiquinone [GO:0006120]	mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]		mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
F7VJQ1	reviewed	APRIO_HUMAN	Alternative prion protein (AltPrP)	PRNP ALTPRP PRIP PRP	Homo sapiens (Human)	73		MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the major prion protein/PRNP from an overlapping reading frame. {ECO:0000305|PubMed:21478263}.; MISCELLANEOUS: The alternative prion protein/AltPrP and PRNP (AC P04156) have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP. In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon (PubMed:21478263). {ECO:0000305|PubMed:21478263}.		mitochondrial outer membrane [GO:0005741]		mitochondrial outer membrane [GO:0005741]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:21478263}; Single-pass membrane protein {ECO:0000269|PubMed:21478263}.
F8VTS6	reviewed	RFAL1_HUMAN	Ret finger protein-like 4A-like protein 1	RFPL4AL1	Homo sapiens (Human)	287			innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]	
G3V0H7	reviewed	SO1B7_HUMAN	Putative solute carrier organic anion transporter family member 1B7 (Liver-specific organic anion transporter 3) (LST-3) (Putative organic anion transporting polypeptide 1B7) (OATP1B7)	SLCO1B7 LST3 LST3TM12	Homo sapiens (Human)	640			sodium-independent organic anion transport [GO:0043252]	plasma membrane [GO:0005886]	serine-type endopeptidase inhibitor activity [GO:0004867]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]	plasma membrane [GO:0005886]; serine-type endopeptidase inhibitor activity [GO:0004867]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; sodium-independent organic anion transport [GO:0043252]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
G5E9R7	reviewed	KR416_HUMAN	Putative keratin-associated protein 4-16 (Keratin-associated protein 4 pseudogene 1) (Keratin-associated protein 4-16 pseudogene)	KRTAP4-16 KRTAP4-16P KRTAP4P1	Homo sapiens (Human)	235	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. {ECO:0000305|PubMed:15955084}.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
H3BQB6	reviewed	STMD1_HUMAN	Stathmin domain-containing protein 1	STMND1	Homo sapiens (Human)	276			microtubule depolymerization [GO:0007019]; neuron projection development [GO:0031175]; regulation of microtubule polymerization or depolymerization [GO:0031110]	cytoplasm [GO:0005737]; neuron projection [GO:0043005]	tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; neuron projection [GO:0043005]; tubulin binding [GO:0015631]; microtubule depolymerization [GO:0007019]; neuron projection development [GO:0031175]; regulation of microtubule polymerization or depolymerization [GO:0031110]	
H3BRN8	reviewed	PIRC2_HUMAN	Piercer of microtubule wall 2 protein	PIERCE2 C15orf65	Homo sapiens (Human)	121	FUNCTION: Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.		axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]	axonemal microtubule [GO:0005879]		axonemal microtubule [GO:0005879]; axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
H3BSY2	reviewed	GOG8M_HUMAN	Golgin subfamily A member 8M	GOLGA8M	Homo sapiens (Human)	632			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
I0J062	reviewed	PANO1_HUMAN	Proapoptotic nucleolar protein 1	PANO1 PANO	Homo sapiens (Human)	215	FUNCTION: Apoptosis-inducing protein that modulates the tumor suppressor function of CDKN2A/p14ARF. Enhances the stability of CDKN2A/p14ARF protein by protecting it from degradation. May act as a tumor suppressor (PubMed:22094112). {ECO:0000269|PubMed:22094112}.		apoptotic process [GO:0006915]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of apoptotic process [GO:0043065]; regulation of protein stability [GO:0031647]	nucleolus [GO:0005730]		nucleolus [GO:0005730]; apoptotic process [GO:0006915]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of apoptotic process [GO:0043065]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:22094112}. Note=Colocalizes with CDKN2A/p14ARF in the nucleolus. {ECO:0000269|PubMed:22094112}.
I1YAP6	reviewed	TRI77_HUMAN	Tripartite motif-containing protein 77	TRIM77 TRIM77P	Homo sapiens (Human)	450			innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
I3L273	reviewed	GFY_HUMAN	Golgi-associated olfactory signaling regulator (Golgi protein in olfactory neurons) (Goofy)	GFY	Homo sapiens (Human)	518	FUNCTION: Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling (By similarity). {ECO:0000250}.		non-motile cilium assembly [GO:1905515]; protein localization to non-motile cilium [GO:0097499]; response to stimulus [GO:0050896]; sensory perception of smell [GO:0007608]	Golgi membrane [GO:0000139]		Golgi membrane [GO:0000139]; non-motile cilium assembly [GO:1905515]; protein localization to non-motile cilium [GO:0097499]; response to stimulus [GO:0050896]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
I3L3R5	reviewed	CCER2_HUMAN	Coiled-coil domain-containing glutamate-rich protein 2	CCER2	Homo sapiens (Human)	266				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
L0R819	reviewed	ASURF_HUMAN	ASNSD1 upstream open reading frame protein (ASNSD1 small/short open reading frame-encoded polypeptide) (ASNSD1-SEP)	ASDURF	Homo sapiens (Human)	96		MISCELLANEOUS: [Isoform 2]: Product of the upstream open reading frame of this bicistronic gene. {ECO:0000303|PubMed:23160002, ECO:0000303|PubMed:23950983, ECO:0000303|PubMed:25857697}.	protein stabilization [GO:0050821]	cytoplasm [GO:0005737]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]		cytoplasm [GO:0005737]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; protein stabilization [GO:0050821]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23160002}.
O00110	reviewed	OVOL3_HUMAN	Putative transcription factor ovo-like protein 3	OVOL3	Homo sapiens (Human)	190	FUNCTION: May act as a transcription regulator. {ECO:0000250}.		epidermal cell differentiation [GO:0009913]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; epidermal cell differentiation [GO:0009913]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O00479	reviewed	HMGN4_HUMAN	High mobility group nucleosome-binding domain-containing protein 4 (Non-histone chromosomal protein HMG-17-like 3) (Non-histone chromosomal protein)	HMGN4 HMG17L3 NHC	Homo sapiens (Human)	90			chromatin organization [GO:0006325]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; nucleosomal DNA binding [GO:0031492]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; nucleosomal DNA binding [GO:0031492]; chromatin organization [GO:0006325]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
O00634	reviewed	NET3_HUMAN	Netrin-3 (Netrin-2-like protein)	NTN3 NTN2L	Homo sapiens (Human)	580	FUNCTION: Netrins control guidance of CNS commissural axons and peripheral motor axons. {ECO:0000250}.		axon guidance [GO:0007411]; regulation of transcription by RNA polymerase II [GO:0006357]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; signaling receptor binding [GO:0005102]; axon guidance [GO:0007411]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
O14498	reviewed	ISLR_HUMAN	Immunoglobulin superfamily containing leucine-rich repeat protein	ISLR UNQ189/PRO215	Homo sapiens (Human)	428			cell adhesion [GO:0007155]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093]		extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O14562	reviewed	UBFD1_HUMAN	Ubiquitin domain-containing protein UBFD1 (Ubiquitin-binding protein homolog)	UBFD1 UBPH	Homo sapiens (Human)	309	FUNCTION: May play a role as NF-kappa-B regulator. {ECO:0000269|PubMed:19285159}.				cadherin binding [GO:0045296]; RNA binding [GO:0003723]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]	
O14581	reviewed	OR7AH_HUMAN	Olfactory receptor 7A17	OR7A17	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O14598	reviewed	VCY1_HUMAN	Testis-specific basic protein Y 1 (Basic charge, Y-linked 1) (Variably charged protein Y)	VCY BPY1 VCY1A; VCY1B BPY1B	Homo sapiens (Human)	125	FUNCTION: May mediate a process in spermatogenesis or may play a role in sex ratio distortion.		brain development [GO:0007420]			brain development [GO:0007420]	
O14604	reviewed	TYB4Y_HUMAN	Thymosin beta-4, Y-chromosomal	TMSB4Y TB4Y	Homo sapiens (Human)	44	FUNCTION: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]	actin monomer binding [GO:0003785]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; actin monomer binding [GO:0003785]; actin filament organization [GO:0007015]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
O14715	reviewed	RGPD8_HUMAN	RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3)	RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3	Homo sapiens (Human)	1765		MISCELLANEOUS: One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.	NLS-bearing protein import into nucleus [GO:0006607]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]	small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; small GTPase binding [GO:0031267]; NLS-bearing protein import into nucleus [GO:0006607]	
O14921	reviewed	RGS13_HUMAN	Regulator of G-protein signaling 13 (RGS13)	RGS13	Homo sapiens (Human)	159	FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity). {ECO:0000250}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GTPase activity [GO:0003924]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]	
O14990	reviewed	IPP2C_HUMAN	Protein phosphatase inhibitor 2 family member C (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 9) (Type-1 protein phosphatase inhibitor 4) (I-4)	PPP1R2C PPP1R2P9	Homo sapiens (Human)	202	FUNCTION: Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-associated phosphates. {ECO:0000269|PubMed:11076525}.		regulation of signal transduction [GO:0009966]		protein phosphatase inhibitor activity [GO:0004864]	protein phosphatase inhibitor activity [GO:0004864]; regulation of signal transduction [GO:0009966]	
O15037	reviewed	KHNYN_HUMAN	Protein KHNYN (KH and NYN domain-containing protein)	KHNYN KIAA0323	Homo sapiens (Human)	678				cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634]	mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521]	
O15050	reviewed	TRNK1_HUMAN	TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog)	TRANK1 KIAA0342 LBA1	Homo sapiens (Human)	2925							
O15255	reviewed	CXX1_HUMAN	CAAX box protein 1 (Cerebral protein 5)	RTL8C CXX1 FAM127A MAR8 MAR8C MART8 hucep-5	Homo sapiens (Human)	209				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
O15442	reviewed	MPPD1_HUMAN	Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB)	MPPED1 C22orf1 FAM1A	Homo sapiens (Human)	326	FUNCTION: May have metallophosphoesterase activity (in vitro). {ECO:0000250}.				hydrolase activity [GO:0016787]	hydrolase activity [GO:0016787]	
O15482	reviewed	TEX28_HUMAN	Testis-specific protein TEX28	TEX28 CXorf2; TEX28P1; TEX28P2	Homo sapiens (Human)	410				endomembrane system [GO:0012505]; membrane [GO:0016020]		endomembrane system [GO:0012505]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
O43246	reviewed	CTR4_HUMAN	Cationic amino acid transporter 4 (CAT-4) (CAT4) (Solute carrier family 7 member 4)	SLC7A4	Homo sapiens (Human)	635	FUNCTION: Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).		amino acid transport [GO:0006865]	membrane [GO:0016020]; plasma membrane [GO:0005886]	amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]	membrane [GO:0016020]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; amino acid transport [GO:0006865]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O43325	reviewed	LYRM1_HUMAN	LYR motif-containing protein 1	LYRM1	Homo sapiens (Human)	122	FUNCTION: May promote cell proliferation and inhibition of apoptosis of preadipocytes. {ECO:0000269|PubMed:19022914}.			midbody [GO:0030496]; nucleoplasm [GO:0005654]		midbody [GO:0030496]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19022914}.
O43361	reviewed	ZN749_HUMAN	Zinc finger protein 749	ZNF749	Homo sapiens (Human)	778	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O43423	reviewed	AN32C_HUMAN	Putative uncharacterized protein ANP32CP (Acidic leucine-rich nuclear phosphoprotein 32 family member C) (Phosphoprotein 32-related protein 1) (Tumorigenic protein pp32r1)	ANP32CP PP32R1	Homo sapiens (Human)	234			nucleocytoplasmic transport [GO:0006913]; regulation of apoptotic process [GO:0042981]	nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	histone binding [GO:0042393]	nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; histone binding [GO:0042393]; nucleocytoplasmic transport [GO:0006913]; regulation of apoptotic process [GO:0042981]	
O43824	reviewed	GTPB6_HUMAN	Putative GTP-binding protein 6 (Pseudoautosomal GTP-binding protein-like)	GTPBP6 PGPL	Homo sapiens (Human)	516		MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.		cytoplasm [GO:0005737]	GTP binding [GO:0005525]; metal ion binding [GO:0046872]; ribosome binding [GO:0043022]	cytoplasm [GO:0005737]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; ribosome binding [GO:0043022]	
O43869	reviewed	OR2T1_HUMAN	Olfactory receptor 2T1 (Olfactory receptor 1-25) (OR1-25) (Olfactory receptor OR1-61)	OR2T1	Homo sapiens (Human)	369	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O60224	reviewed	SSX4_HUMAN	Protein SSX4 (Cancer/testis antigen 5.4) (CT5.4)	SSX4 SSX4A; SSX4B	Homo sapiens (Human)	188	FUNCTION: Could act as a modulator of transcription.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]		nucleus [GO:0005634]; regulation of DNA-templated transcription [GO:0006355]	
O60268	reviewed	K0513_HUMAN	Uncharacterized protein KIAA0513	KIAA0513	Homo sapiens (Human)	411				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:17010949}.
O60287	reviewed	NPA1P_HUMAN	Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog)	URB1 C21orf108 KIAA0539 NOP254 NPA1	Homo sapiens (Human)	2271			maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]	RNA binding [GO:0003723]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16963496}.
O60290	reviewed	ZN862_HUMAN	Zinc finger protein 862	ZNF862 KIAA0543	Homo sapiens (Human)	1169	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O60309	reviewed	L37A3_HUMAN	Leucine-rich repeat-containing protein 37A3	LRRC37A3 KIAA0563	Homo sapiens (Human)	1634				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
O60320	reviewed	EREP2_HUMAN	Protein ENTREP2 (Endosomal transmembrane epsin interactor 2) (Transmembrane protein 228)	ENTREP2 FAM189A1 KIAA0574 TMEM228	Homo sapiens (Human)	539				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O60347	reviewed	TBC12_HUMAN	TBC1 domain family member 12	TBC1D12 KIAA0608	Homo sapiens (Human)	775	FUNCTION: RAB11A-binding protein that plays a role in neurite outgrowth. {ECO:0000250|UniProtKB:M0R7T9}.		regulation of autophagosome assembly [GO:2000785]	autophagosome [GO:0005776]; recycling endosome [GO:0055037]	GTPase activator activity [GO:0005096]	autophagosome [GO:0005776]; recycling endosome [GO:0055037]; GTPase activator activity [GO:0005096]; regulation of autophagosome assembly [GO:2000785]	SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:28384198}.
O60361	reviewed	NDK8_HUMAN	Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6)	NME2P1	Homo sapiens (Human)	137	FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}.		CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; phosphorylation [GO:0016310]; regulation of apoptotic process [GO:0042981]; UTP biosynthetic process [GO:0006228]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; phosphorylation [GO:0016310]; regulation of apoptotic process [GO:0042981]; UTP biosynthetic process [GO:0006228]	
O60403	reviewed	O10H2_HUMAN	Olfactory receptor 10H2 (Olfactory receptor OR19-23)	OR10H2	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O60404	reviewed	O10H3_HUMAN	Olfactory receptor 10H3 (Olfactory receptor OR19-24)	OR10H3	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O60431	reviewed	OR1I1_HUMAN	Olfactory receptor 1I1 (Olfactory receptor 19-20) (OR19-20)	OR1I1	Homo sapiens (Human)	355	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O60518	reviewed	RNBP6_HUMAN	Ran-binding protein 6 (RanBP6)	RANBP6	Homo sapiens (Human)	1105	FUNCTION: May function in nuclear protein import as nuclear transport receptor.		protein import into nucleus [GO:0006606]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; synapse [GO:0045202]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; synapse [GO:0045202]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
O60637	reviewed	TSN3_HUMAN	Tetraspanin-3 (Tspan-3) (Tetraspanin TM4-A) (Transmembrane 4 superfamily member 8)	TSPAN3 TM4SF8	Homo sapiens (Human)	253	FUNCTION: Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair. {ECO:0000250}.			extracellular exosome [GO:0070062]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O60732	reviewed	MAGC1_HUMAN	Melanoma-associated antigen C1 (Cancer/testis antigen 7.1) (CT7.1) (MAGE-C1 antigen)	MAGEC1	Homo sapiens (Human)	1142			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
O60739	reviewed	EIF1B_HUMAN	Eukaryotic translation initiation factor 1b (eIF1b) (Protein translation factor SUI1 homolog GC20)	EIF1B	Homo sapiens (Human)	113	FUNCTION: Probably involved in translation.		regulation of translational initiation [GO:0006446]	eukaryotic 43S preinitiation complex [GO:0016282]	ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	eukaryotic 43S preinitiation complex [GO:0016282]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; regulation of translational initiation [GO:0006446]	
O75290	reviewed	Z780A_HUMAN	Zinc finger protein 780A	ZNF780A	Homo sapiens (Human)	641	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O75333	reviewed	TBX10_HUMAN	T-box transcription factor TBX10 (T-box protein 10)	TBX10 TBX7	Homo sapiens (Human)	385	FUNCTION: Probable transcriptional regulator involved in developmental processes.		anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
O75373	reviewed	ZN737_HUMAN	Zinc finger protein 737 (Zinc finger protein 102)	ZNF737 ZNF102	Homo sapiens (Human)	536	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O75426	reviewed	FBX24_HUMAN	F-box only protein 24	FBXO24 FBX24	Homo sapiens (Human)	580	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.		protein ubiquitination [GO:0016567]	ubiquitin ligase complex [GO:0000151]	ubiquitin-protein transferase activity [GO:0004842]	ubiquitin ligase complex [GO:0000151]; ubiquitin-protein transferase activity [GO:0004842]; protein ubiquitination [GO:0016567]	
O75467	reviewed	Z324A_HUMAN	Zinc finger protein 324A (Zinc finger protein ZF5128)	ZNF324 ZNF324A	Homo sapiens (Human)	553	FUNCTION: May be involved in transcriptional regulation. May be involved in regulation of cell proliferation. {ECO:0000305|PubMed:11779640}.		cell population proliferation [GO:0008283]; G1/S transition of mitotic cell cycle [GO:0000082]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell population proliferation [GO:0008283]; G1/S transition of mitotic cell cycle [GO:0000082]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O75474	reviewed	FRAT2_HUMAN	GSK-3-binding protein FRAT2 (Frequently rearranged in advanced T-cell lymphomas 2) (FRAT-2)	FRAT2	Homo sapiens (Human)	233	FUNCTION: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.		beta-catenin destruction complex disassembly [GO:1904886]; regulation of protein export from nucleus [GO:0046825]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; beta-catenin destruction complex disassembly [GO:1904886]; regulation of protein export from nucleus [GO:0046825]	
O75526	reviewed	RMXL2_HUMAN	RNA-binding motif protein, X-linked-like-2 (Testis-specific heterogeneous nuclear ribonucleoprotein G-T) (hnRNP G-T)	RBMXL2 HNRNPGT	Homo sapiens (Human)	392			mRNA splicing, via spliceosome [GO:0000398]	U12-type spliceosomal complex [GO:0005689]	mRNA binding [GO:0003729]; snRNA binding [GO:0017069]	U12-type spliceosomal complex [GO:0005689]; mRNA binding [GO:0003729]; snRNA binding [GO:0017069]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958650}.
O75794	reviewed	CD123_HUMAN	Cell division cycle protein 123 homolog (Protein D123) (HT-1080) (PZ32)	CDC123 C10orf7 D123	Homo sapiens (Human)	336	FUNCTION: Required for S phase entry of the cell cycle. {ECO:0000250}.		cell cycle [GO:0007049]; cell division [GO:0051301]; eukaryotic translation initiation factor 2 complex assembly [GO:1905143]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of translational initiation [GO:0045948]; regulation of cell cycle [GO:0051726]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; cell cycle [GO:0007049]; cell division [GO:0051301]; eukaryotic translation initiation factor 2 complex assembly [GO:1905143]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of translational initiation [GO:0045948]; regulation of cell cycle [GO:0051726]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
O75949	reviewed	NALF2_HUMAN	NALCN channel auxiliary factor 2 (Protein TED) (Transmembrane protein 28) (Transmembrane protein FAM155B)	NALF2 FAM155B TED TMEM28	Homo sapiens (Human)	472	FUNCTION: Probable component of the NALCN channel complex, a channel that regulates the resting membrane potential and controls neuronal excitability. {ECO:0000305|PubMed:32494638}.		calcium ion import across plasma membrane [GO:0098703]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; calcium ion import across plasma membrane [GO:0098703]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
O75954	reviewed	TSN9_HUMAN	Tetraspanin-9 (Tspan-9) (Tetraspan NET-5)	TSPAN9 NET5	Homo sapiens (Human)	239				focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197]		focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with GP6 in tetraspanin microdomains on the platelet surface. {ECO:0000250}.
O76000	reviewed	OR2B3_HUMAN	Putative olfactory receptor 2B3 (Hs6M1-1) (Olfactory receptor OR6-14) (OR6-4) (Olfactory receptor 6-4)	OR2B3 OR2B3P	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O76038	reviewed	SEGN_HUMAN	Secretagogin	SCGN SECRET	Homo sapiens (Human)	276			regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; nucleus [GO:0005634]; synapse [GO:0045202]; terminal bouton [GO:0043195]; transport vesicle membrane [GO:0030658]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; nucleus [GO:0005634]; synapse [GO:0045202]; terminal bouton [GO:0043195]; transport vesicle membrane [GO:0030658]; calcium ion binding [GO:0005509]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]	SUBCELLULAR LOCATION: Cytoplasm. Secreted {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions (By similarity). Detectable in human serum after ischemic neuronal damage. {ECO:0000250}.
O76087	reviewed	GAGE7_HUMAN	G antigen 7 (GAGE-7) (AL4) (Cancer/testis antigen 4.7) (CT4.7) (GAGE-12I) (GAGE-7B) (GAGE-8)	GAGE7 GAGE12I GAGE7B	Homo sapiens (Human)	117		MISCELLANEOUS: This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
O76100	reviewed	OR7AA_HUMAN	Olfactory receptor 7A10 (OST027) (Olfactory receptor OR19-18)	OR7A10	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O94819	reviewed	KBTBB_HUMAN	Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B)	KBTBD11 CMLAP KIAA0711 KLHDC7C	Homo sapiens (Human)	623							
O94952	reviewed	FBX21_HUMAN	F-box only protein 21	FBXO21 FBX21 KIAA0875	Homo sapiens (Human)	628	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: May be due to a competing acceptor splice site.	ubiquitin-dependent protein catabolic process [GO:0006511]	cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]	DNA binding [GO:0003677]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]; DNA binding [GO:0003677]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-dependent protein catabolic process [GO:0006511]	
O95006	reviewed	OR2F2_HUMAN	Olfactory receptor 2F2 (Olfactory receptor 7-1) (OR7-1) (Olfactory receptor OR7-6)	OR2F2	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O95013	reviewed	O4F21_HUMAN	Olfactory receptor 4F21	OR4F21 OR4F21P	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O95081	reviewed	AGFG2_HUMAN	Arf-GAP domain and FG repeat-containing protein 2 (HIV-1 Rev-binding protein-like protein) (Rev/Rex activation domain-binding protein related) (RAB-R)	AGFG2 HRBL RABR	Homo sapiens (Human)	481				cytoplasm [GO:0005737]; membrane [GO:0016020]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; membrane [GO:0016020]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	
O95156	reviewed	NXPH2_HUMAN	Neurexophilin-2	NXPH2 NPH2	Homo sapiens (Human)	264	FUNCTION: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. {ECO:0000305}.		neuropeptide signaling pathway [GO:0007218]	extracellular region [GO:0005576]	signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; signaling receptor binding [GO:0005102]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O95157	reviewed	NXPH3_HUMAN	Neurexophilin-3	NXPH3 KIAA1159 NPH3 UNQ687/PRO1327	Homo sapiens (Human)	252	FUNCTION: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity). {ECO:0000250}.		neuropeptide signaling pathway [GO:0007218]	extracellular region [GO:0005576]	signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; signaling receptor binding [GO:0005102]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O95158	reviewed	NXPH4_HUMAN	Neurexophilin-4	NXPH4 NPH4 UNQ1928/PRO4403	Homo sapiens (Human)	308	FUNCTION: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. {ECO:0000305}.		neuropeptide signaling pathway [GO:0007218]	extracellular region [GO:0005576]	signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; signaling receptor binding [GO:0005102]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O95170	reviewed	CDRT1_HUMAN	F-box and WD repeat domain containing protein 10B (CMT1A duplicated region transcript 1 protein)	FBXW10B C17orf1 C17orf1A CDRT1 HREP	Homo sapiens (Human)	752		MISCELLANEOUS: FBXW10B gene is located centromeric to and partially within proximal CMT1A-REP element. CMT1A-REP is a complex binary repeat element flanking a 1.5-Mb DNA region duplicated in Charcot-Marie-Tooth disease type I (CMT1A) or deleted in Hereditary neuropathy (HNPP).					
O95221	reviewed	OR5F1_HUMAN	Olfactory receptor 5F1 (Olfactory receptor 11-10) (OR11-10) (Olfactory receptor OR11-167)	OR5F1	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
O95424	reviewed	DEXI_HUMAN	Dexamethasone-induced protein (Protein MYLE)	DEXI MYLE	Homo sapiens (Human)	95							
O95478	reviewed	NSA2_HUMAN	Ribosome biogenesis protein NSA2 homolog (Hairy cell leukemia protein 1) (TGF-beta-inducible nuclear protein 1)	NSA2 TINP1 HUSSY-29	Homo sapiens (Human)	260	FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). {ECO:0000250}.		maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]	nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]; RNA binding [GO:0003723]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
O95502	reviewed	NPTXR_HUMAN	Neuronal pentraxin receptor	NPTXR	Homo sapiens (Human)	500	FUNCTION: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. {ECO:0000250}.			glutamatergic synapse [GO:0098978]; membrane [GO:0016020]	metal ion binding [GO:0046872]	glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
O95521	reviewed	PRAM1_HUMAN	PRAME family member 1	PRAMEF1	Homo sapiens (Human)	474			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
O95744	reviewed	PM2P2_HUMAN	Putative postmeiotic segregation increased 2-like protein 2 (Postmeiotic segregation increased 2-like protein 14) (Postmeiotic segregation increased protein 4) (Putative postmeiotic segregation increased 2 pseudogene 2)	PMS2P2 PMS2L14 PMS2L2 PMS4	Homo sapiens (Human)	297		MISCELLANEOUS: Encoded by one of the numerous copies of postmeiotic segregation increased 2-like genes scattered in the q11-q22 region of the chromosome 7.	mismatch repair [GO:0006298]	mismatch repair complex [GO:0032300]	ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]	mismatch repair complex [GO:0032300]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatch repair [GO:0006298]	
O95800	reviewed	GPR75_HUMAN	Probable G-protein coupled receptor 75	GPR75	Homo sapiens (Human)	540	FUNCTION: G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. {ECO:0000250|UniProtKB:Q6X632, ECO:0000303|PubMed:23979485}.		chemokine-mediated signaling pathway [GO:0070098]; G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	C-C chemokine receptor activity [GO:0016493]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; C-C chemokine receptor activity [GO:0016493]; G protein-coupled receptor activity [GO:0004930]; chemokine-mediated signaling pathway [GO:0070098]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000305}.
O95825	reviewed	QORL1_HUMAN	Quinone oxidoreductase-like protein 1 (EC 1.-.-.-) (Protein 4P11) (Quinone oxidoreductase homolog 1) (QOH-1) (Zeta-crystallin homolog)	CRYZL1 4P11	Homo sapiens (Human)	349			quinone metabolic process [GO:1901661]	cytosol [GO:0005829]	NADP binding [GO:0050661]; NADPH:quinone reductase activity [GO:0003960]	cytosol [GO:0005829]; NADP binding [GO:0050661]; NADPH:quinone reductase activity [GO:0003960]; quinone metabolic process [GO:1901661]	
O95857	reviewed	TSN13_HUMAN	Tetraspanin-13 (Tspan-13) (Tetraspan NET-6) (Transmembrane 4 superfamily member 13)	TSPAN13 NET6 TM4SF13 UNQ260/PRO296	Homo sapiens (Human)	204			regulation of calcium ion transmembrane transport [GO:1903169]	membrane [GO:0016020]; plasma membrane [GO:0005886]	calcium channel regulator activity [GO:0005246]	membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium channel regulator activity [GO:0005246]; regulation of calcium ion transmembrane transport [GO:1903169]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O95969	reviewed	SG1D2_HUMAN	Secretoglobin family 1D member 2 (Lipophilin-B)	SCGB1D2 LIPHB LPNB	Homo sapiens (Human)	90	FUNCTION: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.			extracellular space [GO:0005615]		extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O96001	reviewed	PPR17_HUMAN	Protein phosphatase 1 regulatory subunit 17 (G-substrate)	PPP1R17 C7orf16 GSBS	Homo sapiens (Human)	155	FUNCTION: Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes. {ECO:0000250}.		central nervous system development [GO:0007417]; intracellular signal transduction [GO:0035556]; regulation of phosphatase activity [GO:0010921]		protein serine/threonine phosphatase inhibitor activity [GO:0004865]	protein serine/threonine phosphatase inhibitor activity [GO:0004865]; central nervous system development [GO:0007417]; intracellular signal transduction [GO:0035556]; regulation of phosphatase activity [GO:0010921]	
P01737	reviewed	TVA84_HUMAN	T cell receptor alpha variable 8-4 (T cell receptor alpha chain V region PY14)	TRAV8-4	Homo sapiens (Human)	113	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
P03986	reviewed	TRGC2_HUMAN	T cell receptor gamma constant 2	TRGC2 TCRGC2	Homo sapiens (Human)	189	FUNCTION: Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; gamma-delta T cell receptor complex [GO:0042106]; plasma membrane [GO:0005886]	transmembrane signaling receptor activity [GO:0004888]	external side of plasma membrane [GO:0009897]; gamma-delta T cell receptor complex [GO:0042106]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
P09131	reviewed	P3_HUMAN	P3 protein (Solute carrier family 10 member 3)	SLC10A3 DXS253E P3	Homo sapiens (Human)	477	FUNCTION: The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.		bile acid and bile salt transport [GO:0015721]; response to retinoic acid [GO:0032526]	membrane [GO:0016020]	bile acid:sodium symporter activity [GO:0008508]	membrane [GO:0016020]; bile acid:sodium symporter activity [GO:0008508]; bile acid and bile salt transport [GO:0015721]; response to retinoic acid [GO:0032526]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P0C025	reviewed	NUD17_HUMAN	Nucleoside diphosphate-linked moiety X motif 17 (Nudix motif 17) (EC 3.6.1.-)	NUDT17	Homo sapiens (Human)	328	FUNCTION: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. {ECO:0000250}.		NAD catabolic process [GO:0019677]; NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742]	peroxisome [GO:0005777]	metal ion binding [GO:0046872]; NADH pyrophosphatase activity [GO:0035529]	peroxisome [GO:0005777]; metal ion binding [GO:0046872]; NADH pyrophosphatase activity [GO:0035529]; NAD catabolic process [GO:0019677]; NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742]	
P0C091	reviewed	FREM3_HUMAN	FRAS1-related extracellular matrix protein 3	FREM3	Homo sapiens (Human)	2139	FUNCTION: Extracellular matrix protein which may play a role in cell adhesion. {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell communication [GO:0007154]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; membrane [GO:0016020]	metal ion binding [GO:0046872]	basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; membrane [GO:0016020]; metal ion binding [GO:0046872]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell communication [GO:0007154]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
P0C0P6	reviewed	NPS_HUMAN	Neuropeptide S	NPS	Homo sapiens (Human)	89	FUNCTION: Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440). {ECO:0000250, ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:16790440}.		neuropeptide signaling pathway [GO:0007218]; positive regulation of action potential [GO:0045760]; positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; synaptic transmission, glutamatergic [GO:0035249]; visual learning [GO:0008542]	extracellular region [GO:0005576]; synapse [GO:0045202]		extracellular region [GO:0005576]; synapse [GO:0045202]; neuropeptide signaling pathway [GO:0007218]; positive regulation of action potential [GO:0045760]; positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; synaptic transmission, glutamatergic [GO:0035249]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Secreted.
P0C5J1	reviewed	F86B2_HUMAN	Putative protein N-methyltransferase FAM86B2 (EC 2.1.1.-)	FAM86B2	Homo sapiens (Human)	330			methylation [GO:0032259]	protein-containing complex [GO:0032991]	protein-lysine N-methyltransferase activity [GO:0016279]	protein-containing complex [GO:0032991]; protein-lysine N-methyltransferase activity [GO:0016279]; methylation [GO:0032259]	
P0C5Y4	reviewed	KRA14_HUMAN	Keratin-associated protein 1-4 (High sulfur keratin-associated protein 1.4) (Keratin-associated protein 1.4)	KRTAP1-4 KAP1.4 KRTAP1.4	Homo sapiens (Human)	121	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
P0C604	reviewed	OR4A8_HUMAN	Olfactory receptor 4A8 (Olfactory receptor OR11-110)	OR4A8 OR4A8P	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0C623	reviewed	OR4Q2_HUMAN	Olfactory receptor 4Q2 (olfactory receptor OR14-21)	OR4Q2 OR4Q2P	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0C626	reviewed	OR5G3_HUMAN	Olfactory receptor 5G3 (Olfactory receptor 5G6) (Olfactory receptor OR11-213)	OR5G3 OR5G3P OR5G6P	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0C628	reviewed	O5AC1_HUMAN	Olfactory receptor 5AC1 (Olfactory receptor OR3-2)	OR5AC1 OR5AC1P	Homo sapiens (Human)	307	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0C629	reviewed	O10J4_HUMAN	Olfactory receptor 10J4	OR10J4 OR10J4P	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0C646	reviewed	O52Z1_HUMAN	Olfactory receptor 52Z1P	OR52Z1P OR52Z1	Homo sapiens (Human)	298	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
P0C6A0	reviewed	ZGLP1_HUMAN	GATA-type zinc finger protein 1 (GATA-like protein 1) (GLP-1)	ZGLP1 GLP1	Homo sapiens (Human)	271	FUNCTION: Transcriptional regulator that plays a key role in germ cell development. Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry. Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells. Regulates expression of STRA8, a central downstream effector for the meiotic program. Acts independently of retinoic acid (RA). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase. {ECO:0000250|UniProtKB:Q1WG82}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte development [GO:0048599]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte development [GO:0048599]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q1WG82}.
P0C6S8	reviewed	LIGO3_HUMAN	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (Leucine-rich repeat neuronal protein 2) (Leucine-rich repeat neuronal protein 6B)	LINGO3 LERN2 LRRN6B	Homo sapiens (Human)	592				extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
P0C7A2	reviewed	F153B_HUMAN	Protein FAM153B	FAM153B	Homo sapiens (Human)	387							
P0C7H9	reviewed	U17L7_HUMAN	Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7	USP17L7	Homo sapiens (Human)	530			regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
P0C7I0	reviewed	U17L8_HUMAN	Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8	USP17L8	Homo sapiens (Human)	530			regulation of apoptotic process [GO:0042981]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]; regulation of apoptotic process [GO:0042981]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
P0C7N1	reviewed	OR8U8_HUMAN	Olfactory receptor 8U8	OR8U8	Homo sapiens (Human)	319	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0C7N5	reviewed	OR8U9_HUMAN	Olfactory receptor 8U9	OR8U9	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0C7P4	reviewed	UCRIL_HUMAN	Putative cytochrome b-c1 complex subunit Rieske-like protein 1 (Ubiquinol-cytochrome c reductase Rieske iron-sulfur subunit pseudogene 1)	UQCRFS1P1 UQCRFSL1	Homo sapiens (Human)	283			mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	mitochondrial respiratory chain complex III [GO:0005750]	2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; ubiquinol-cytochrome-c reductase activity [GO:0008121]	mitochondrial respiratory chain complex III [GO:0005750]; 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
P0C7Q2	reviewed	ARMS2_HUMAN	Age-related maculopathy susceptibility protein 2	ARMS2	Homo sapiens (Human)	107			retina homeostasis [GO:0001895]	mitochondrion [GO:0005739]; photoreceptor inner segment [GO:0001917]		mitochondrion [GO:0005739]; photoreceptor inner segment [GO:0001917]; retina homeostasis [GO:0001895]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16174643, ECO:0000269|PubMed:19255159}.
P0C7Q6	reviewed	S35G6_HUMAN	Solute carrier family 35 member G6 (Acyl-malonyl-condensing enzyme 1-like protein 3) (Transmembrane protein 21B)	SLC35G6 AMAC1L3 TMEM21B	Homo sapiens (Human)	338		MISCELLANEOUS: This gene appears to be the source locus of an SVA-mediated retrotransposition event that gave rise to SLC35G3, SLC35G4 and SLC35G5 genes.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P0C7T2	reviewed	OR2T7_HUMAN	Olfactory receptor 2T7 (OST723) (olfactory receptor OR1-44)	OR2T7 OR2T7P	Homo sapiens (Human)	308	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0C7T3	reviewed	O56A5_HUMAN	Olfactory receptor 56A5	OR56A5 OR56A5P	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0C7T4	reviewed	HMSDV_HUMAN	Minor histocompatibility protein HMSD variant form (HSMD-v) [Cleaved into: Minor histocompatibility antigen ACC-6 (mHA ACC-6)]	HMSD C18orf53	Homo sapiens (Human)	53	FUNCTION: This splice variant of HMSD is the precursor of the histocompatibility antigen ACC-6. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. However, associated with GVHD, a favorable graft-versus-leukemia (GVL) can be induced by donor-recipient disparities in mHags. ACC-6 is presented to the cell surface by MHC HLA-B*4403. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. Immunogenicity of most autosomal mHags results from single-nucleotide polymorphisms that cause amino-acid substitutions within epitopes, leading to the differential recognition of peptides between donor and recipient. {ECO:0000269|PubMed:17409267}.		activation of immune response [GO:0002253]; cytolysis [GO:0019835]; positive regulation of type II interferon production [GO:0032729]			activation of immune response [GO:0002253]; cytolysis [GO:0019835]; positive regulation of type II interferon production [GO:0032729]	
P0C7U1	reviewed	ASA2B_HUMAN	Putative inactive neutral ceramidase B (ASAH2-like protein) (Putative inactive N-acylsphingosine amidohydrolase 2B) (Putative inactive non-lysosomal ceramidase B)	ASAH2B ASAH2C ASAH2L	Homo sapiens (Human)	165		MISCELLANEOUS: ASAH2B/ASAH2L is a partial paralog of ASAH2, resulting from a partial duplication of ASAH2 on chromosome 10. It has a polymorphic start codon with a single nucleotide change of the original ASAH2 sequence plus other putative translation start site that might lead to several potential ORFs.	ceramide catabolic process [GO:0046514]		N-acylsphingosine amidohydrolase activity [GO:0017040]	N-acylsphingosine amidohydrolase activity [GO:0017040]; ceramide catabolic process [GO:0046514]	
P0C7V7	reviewed	SC11B_HUMAN	Putative signal peptidase complex catalytic subunit SEC11B (EC 3.4.21.89) (SEC11 homolog B) (SEC11-like protein 2)	SEC11B SEC11L2 SPCS4B	Homo sapiens (Human)	166	FUNCTION: Putative component of some signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.		signal peptide processing [GO:0006465]	signal peptidase complex [GO:0005787]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	signal peptidase complex [GO:0005787]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; signal peptide processing [GO:0006465]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
P0C7X1	reviewed	TBC3H_HUMAN	TBC1 domain family member 3H	TBC1D3H	Homo sapiens (Human)	549	FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250}.	MISCELLANEOUS: TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor. {ECO:0000305}.		plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associated with lipid rafts. {ECO:0000250}.
P0C851	reviewed	PIRT_HUMAN	Phosphoinositide-interacting protein	PIRT	Homo sapiens (Human)	137	FUNCTION: Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity). {ECO:0000250}.		behavioral response to pain [GO:0048266]; phosphatidylinositol-mediated signaling [GO:0048015]; response to heat [GO:0009408]	plasma membrane [GO:0005886]	phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; transmembrane transporter binding [GO:0044325]	plasma membrane [GO:0005886]; phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; transmembrane transporter binding [GO:0044325]; behavioral response to pain [GO:0048266]; phosphatidylinositol-mediated signaling [GO:0048015]; response to heat [GO:0009408]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P0C860	reviewed	MS3L2_HUMAN	Putative male-specific lethal-3 protein-like 2 (MSL3-like 2) (Male-specific lethal-3 homolog 2) (Male-specific lethal-3 homolog pseudogene 1)	MSL3P1 MSL3L2	Homo sapiens (Human)	447	FUNCTION: May be involved in chromatin remodeling and transcriptional regulation. {ECO:0000250}.		chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355]	MSL complex [GO:0072487]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]		MSL complex [GO:0072487]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]; chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00972}.
P0CB33	reviewed	ZN735_HUMAN	Putative zinc finger protein 735 (Zinc finger protein 735 pseudogene)	ZNF735 ZNF735P	Homo sapiens (Human)	412	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P0CB38	reviewed	PAB4L_HUMAN	Polyadenylate-binding protein 4-like (PABP-4-like) (Poly(A)-binding protein 4-like)	PABPC4L	Homo sapiens (Human)	370	FUNCTION: May bind RNA. {ECO:0000305}.			cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]	
P0CF51	reviewed	TRGC1_HUMAN	T cell receptor gamma constant 1	TRGC1 TCRGC1	Homo sapiens (Human)	173	FUNCTION: Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]; gamma-delta T cell activation [GO:0046629]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]; gamma-delta T cell receptor complex [GO:0042106]	small molecule binding [GO:0036094]	external side of plasma membrane [GO:0009897]; gamma-delta T cell receptor complex [GO:0042106]; small molecule binding [GO:0036094]; adaptive immune response [GO:0002250]; gamma-delta T cell activation [GO:0046629]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
P0CG00	reviewed	ZSA5D_HUMAN	Putative zinc finger and SCAN domain-containing protein 5D (Zinc finger and SCAN domain-containing protein 5D pseudogene)	ZSCAN5DP ZSCAN5D	Homo sapiens (Human)	497			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
P0CG01	reviewed	GKN3_HUMAN	Gastrokine-3	GKN3P	Homo sapiens (Human)	181	FUNCTION: May inhibit gastric epithelial cell proliferation. {ECO:0000250}.		regulation of cell population proliferation [GO:0042127]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
P0CG12	reviewed	DERPC_HUMAN	Decreased expression in renal and prostate cancer protein	DERPC	Homo sapiens (Human)	524	FUNCTION: Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269|PubMed:12477976}.	MISCELLANEOUS: Found in a common chromosomal region of deletion in breast cancer.		extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]		extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12477976}.
P0CG22	reviewed	DR4L1_HUMAN	Putative dehydrogenase/reductase SDR family member 4-like 1 (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 25C member 4) (Protein SDR25C4)	DHRS4L1 SDR25C4	Homo sapiens (Human)	281	FUNCTION: Putative oxidoreductase. {ECO:0000250}.	MISCELLANEOUS: Three homologous proteins DHRS4, DHRS4L1, and DHRS4L2 are derived from gene duplication of DHRS4, and the gene cluster is arranged in tandem in chromosome 14. {ECO:0000269|PubMed:27323117}.	retinal metabolic process [GO:0042574]	peroxisome [GO:0005777]	carbonyl reductase (NADPH) activity [GO:0004090]	peroxisome [GO:0005777]; carbonyl reductase (NADPH) activity [GO:0004090]; retinal metabolic process [GO:0042574]	
P0CG31	reviewed	Z286B_HUMAN	Putative zinc finger protein 286B	ZNF286B ZNF286C ZNF286L	Homo sapiens (Human)	522	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P0CG36	reviewed	CFC1B_HUMAN	Cryptic family protein 1B	CFC1B	Homo sapiens (Human)	223			anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; determination of left/right symmetry [GO:0007368]; gastrulation [GO:0007369]; heart development [GO:0007507]; nodal signaling pathway [GO:0038092]	cell surface [GO:0009986]; extracellular region [GO:0005576]	activin receptor binding [GO:0070697]; nodal binding [GO:0038100]	cell surface [GO:0009986]; extracellular region [GO:0005576]; activin receptor binding [GO:0070697]; nodal binding [GO:0038100]; anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; determination of left/right symmetry [GO:0007368]; gastrulation [GO:0007369]; heart development [GO:0007507]; nodal signaling pathway [GO:0038092]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P0CG40	reviewed	SP9_HUMAN	Transcription factor Sp9	SP9	Homo sapiens (Human)	484	FUNCTION: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). {ECO:0000250}.		embryonic limb morphogenesis [GO:0030326]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; embryonic limb morphogenesis [GO:0030326]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P0CH99	reviewed	Z705D_HUMAN	Zinc finger protein 705D	ZNF705D	Homo sapiens (Human)	300	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P0CI26	reviewed	TR49C_HUMAN	Tripartite motif-containing protein 49C (Tripartite motif-containing protein 49-like protein 2)	TRIM49C TRIM49L2	Homo sapiens (Human)	452			innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
P0CJ72	reviewed	HMN5_HUMAN	Humanin-like 5 (HN5) (MT-RNR2-like protein 5)	MTRNR2L5	Homo sapiens (Human)	24	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9, ECO:0000269|PubMed:19477263}.		cellular response to staurosporine [GO:0072734]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109]	extracellular region [GO:0005576]; mitochondrion [GO:0005739]	receptor antagonist activity [GO:0048019]	extracellular region [GO:0005576]; mitochondrion [GO:0005739]; receptor antagonist activity [GO:0048019]; cellular response to staurosporine [GO:0072734]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ78	reviewed	ZN865_HUMAN	Zinc finger protein 865	ZNF865	Homo sapiens (Human)	1059	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P0CJ79	reviewed	ZN888_HUMAN	Zinc finger protein 888	ZNF888	Homo sapiens (Human)	718	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P0CK96	reviewed	S352B_HUMAN	Solute carrier family 35 member E2B	SLC35E2B KIAA0447	Homo sapiens (Human)	405	FUNCTION: Putative transporter. {ECO:0000250}.		blastocyst hatching [GO:0001835]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	antiporter activity [GO:0015297]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; antiporter activity [GO:0015297]; blastocyst hatching [GO:0001835]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P0CK97	reviewed	S35E2_HUMAN	Solute carrier family 35 member E2A	SLC35E2A SLC35E2	Homo sapiens (Human)	266	FUNCTION: Putative transporter. {ECO:0000250}.			Golgi apparatus [GO:0005794]; membrane [GO:0016020]	antiporter activity [GO:0015297]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; antiporter activity [GO:0015297]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P0CL82	reviewed	GG12I_HUMAN	G antigen 12I (GAGE-12I)	GAGE12I	Homo sapiens (Human)	117		MISCELLANEOUS: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
P0CV98	reviewed	TSPY3_HUMAN	Testis-specific Y-encoded protein 3	TSPY3	Homo sapiens (Human)	308	FUNCTION: May be involved in sperm differentiation and proliferation. {ECO:0000250|UniProtKB:Q01534}.		cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01534}. Nucleus {ECO:0000250|UniProtKB:Q01534}.
P0CV99	reviewed	TSPY4_HUMAN	Testis-specific Y-encoded protein 4	TSPY4	Homo sapiens (Human)	314	FUNCTION: May be involved in sperm differentiation and proliferation. {ECO:0000250|UniProtKB:Q01534}.		cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01534}. Nucleus {ECO:0000250|UniProtKB:Q01534}.
P0CW00	reviewed	TSPY8_HUMAN	Testis-specific Y-encoded protein 8	TSPY8	Homo sapiens (Human)	308	FUNCTION: May be involved in sperm differentiation and proliferation. {ECO:0000250|UniProtKB:Q01534}.		cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01534}. Nucleus {ECO:0000250|UniProtKB:Q01534}.
P0CW01	reviewed	TSPYA_HUMAN	Testis-specific Y-encoded protein 10	TSPY10	Homo sapiens (Human)	308	FUNCTION: May be involved in sperm differentiation and proliferation. {ECO:0000250|UniProtKB:Q01534}.		cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01534}. Nucleus {ECO:0000250|UniProtKB:Q01534}.
P0CW20	reviewed	LIMS4_HUMAN	LIM and senescent cell antigen-like-containing domain protein 4 (LIM and senescent cell antigen-like-containing domain protein 3-like)	LIMS4 LIMS3L	Homo sapiens (Human)	117				cellular anatomical entity [GO:0110165]	metal ion binding [GO:0046872]	cellular anatomical entity [GO:0110165]; metal ion binding [GO:0046872]	
P0DJD0	reviewed	RGPD1_HUMAN	RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6)	RGPD1 RANBP2L6 RGP1	Homo sapiens (Human)	1748		MISCELLANEOUS: One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.	NLS-bearing protein import into nucleus [GO:0006607]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]		cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; NLS-bearing protein import into nucleus [GO:0006607]	
P0DJD1	reviewed	RGPD2_HUMAN	RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2)	RGPD2 RANBP2L2 RGP2	Homo sapiens (Human)	1756		MISCELLANEOUS: One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.	NLS-bearing protein import into nucleus [GO:0006607]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]		cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; NLS-bearing protein import into nucleus [GO:0006607]	
P0DKB6	reviewed	MPC1L_HUMAN	Mitochondrial pyruvate carrier 1-like protein	MPC1L	Homo sapiens (Human)	136	FUNCTION: Mediates the uptake of pyruvate into mitochondria. {ECO:0000269|PubMed:27317664}.		mitochondrial pyruvate transmembrane transport [GO:0006850]	mitochondrial inner membrane [GO:0005743]	pyruvate transmembrane transporter activity [GO:0050833]	mitochondrial inner membrane [GO:0005743]; pyruvate transmembrane transporter activity [GO:0050833]; mitochondrial pyruvate transmembrane transport [GO:0006850]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:27317664}; Multi-pass membrane protein {ECO:0000255}.
P0DKV0	reviewed	S31C1_HUMAN	Putative spermatogenesis-associated protein 31C1 (Protein FAM75C1)	SPATA31C1 FAM75C1	Homo sapiens (Human)	1188	FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P0DM35	reviewed	M1BL1_HUMAN	Metallothionein 1H-like protein 1	MT1HL1	Homo sapiens (Human)	61	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. {ECO:0000250}.		cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]	
P0DMP2	reviewed	SRG2B_HUMAN	SLIT-ROBO Rho GTPase-activating protein 2B (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2)	SRGAP2B SRGAP2P2	Homo sapiens (Human)	458	FUNCTION: May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2 (PubMed:31822692, PubMed:31822692). In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood (PubMed:31822692). {ECO:0000269|PubMed:31822692, ECO:0000305|PubMed:22559944, ECO:0000305|PubMed:31822692}.	MISCELLANEOUS: This is one of the 3 duplications of the ancestral gene SRGAP2/SRGAP2A which has undergone human-specific segmental gene duplications (PubMed:22559944). The appearance of SRGAP2B in the human genome is estimated to 3,4 million years. Two larger duplications later copied SRGAP2B to chromosome 1p12 (SRGAP2C) and to proximal 1q21.1 (SRGAP2D) (PubMed:22559944). SRGAP2B was identified in some individuals but it is not clear if it produces a functional protein (PubMed:22559944). {ECO:0000305|PubMed:22559944}.	nervous system development [GO:0007399]			nervous system development [GO:0007399]	
P0DMT0	reviewed	MLN_HUMAN	Myoregulin	MRLN MLN	Homo sapiens (Human)	46	FUNCTION: Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. {ECO:0000250|UniProtKB:Q9CV60, ECO:0000269|PubMed:25640239}.		calcium ion import into sarcoplasmic reticulum [GO:1990036]; negative regulation of calcium ion import into sarcoplasmic reticulum [GO:1902081]; response to wounding [GO:0009611]	sarcoplasmic reticulum membrane [GO:0033017]	enzyme inhibitor activity [GO:0004857]	sarcoplasmic reticulum membrane [GO:0033017]; enzyme inhibitor activity [GO:0004857]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; negative regulation of calcium ion import into sarcoplasmic reticulum [GO:1902081]; response to wounding [GO:0009611]	SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9CV60}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9CV60}.
P0DMU2	reviewed	OR83P_HUMAN	Putative olfactory receptor 8G3 pseudogene (Olfactory receptor OR11-297)	OR8G3P	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0DN37	reviewed	PAL4G_HUMAN	Peptidyl-prolyl cis-trans isomerase A-like 4G (PPIase A-like 4G) (EC 5.2.1.8) (Peptidylprolyl cis-trans isomerase A-like 4)	PPIAL4G	Homo sapiens (Human)	164	FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.	MISCELLANEOUS: It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1. {ECO:0000305}.	protein folding [GO:0006457]	cytoplasm [GO:0005737]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62937}.
P0DN80	reviewed	OR5H8_HUMAN	Olfactory receptor 5H8 (Olfactory receptor 5H8 pseudogene) (Olfactory receptor OR3-7)	OR5H8 OR5H8P	Homo sapiens (Human)	308	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
P0DN81	reviewed	O13C7_HUMAN	Olfactory receptor 13C7	OR13C7 OR13C7P	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
P0DN82	reviewed	O12D1_HUMAN	Olfactory receptor 12D1	OR12D1 OR12D1P	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
P0DP01	reviewed	HV108_HUMAN	Immunoglobulin heavy variable 1-8	IGHV1-8	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DP02	reviewed	HVC33_HUMAN	Immunoglobulin heavy variable 3-30-3	IGHV3-30-3	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DP03	reviewed	HVC05_HUMAN	Immunoglobulin heavy variable 3-30-5	IGHV3-30-5	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DP04	reviewed	HV43D_HUMAN	Immunoglobulin heavy variable 3-43D	IGHV3-43D	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DP06	reviewed	HVD34_HUMAN	Immunoglobulin heavy variable 4-30-4	IGHV4-30-4	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DP07	reviewed	HV431_HUMAN	Immunoglobulin heavy variable 4-31	IGHV4-31	Homo sapiens (Human)	118	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DP08	reviewed	HVD82_HUMAN	Immunoglobulin heavy variable 4-38-2	IGHV4-38-2	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DP09	reviewed	KV113_HUMAN	Immunoglobulin kappa variable 1-13	IGKV1-13	Homo sapiens (Human)	117	FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DP72	reviewed	VSXL2_HUMAN	V-set and immunoglobulin domain-containing protein 10-like 2	VSIG10L2	Homo sapiens (Human)	767			cell-cell adhesion [GO:0098609]	cell-cell junction [GO:0005911]; membrane [GO:0016020]	cell adhesion molecule binding [GO:0050839]	cell-cell junction [GO:0005911]; membrane [GO:0016020]; cell adhesion molecule binding [GO:0050839]; cell-cell adhesion [GO:0098609]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
P0DP73	reviewed	D130B_HUMAN	Beta-defensin 130B	DEFB130B	Homo sapiens (Human)	79	FUNCTION: Antimicrobial host-defense peptide. Has an antiplasmodial activity. {ECO:0000269|PubMed:28181499}.		cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]	extracellular space [GO:0005615]	CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]	extracellular space [GO:0005615]; CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]; cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P0DP74	reviewed	D130A_HUMAN	Beta-defensin 130A (Beta-defensin 130) (Beta-defensin 30) (DEFB-30) (Defensin, beta 130)	DEFB130A DEFB130 DEFB30	Homo sapiens (Human)	79	FUNCTION: Antimicrobial host-defense peptide. Has an antiplasmodial activity. {ECO:0000269|PubMed:28181499}.		cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]	extracellular space [GO:0005615]	CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]	extracellular space [GO:0005615]; CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]; cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P0DPB5	reviewed	RPC22_HUMAN	Protein POLR1D, isoform 2	POLR1D	Homo sapiens (Human)	122				cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	
P0DPF3	reviewed	NBPF9_HUMAN	Neuroblastoma breakpoint family member 9	NBPF9	Homo sapiens (Human)	1111		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P0DPF4	reviewed	TVA35_HUMAN	T cell receptor alpha variable 35	TRAV35	Homo sapiens (Human)	110	FUNCTION: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
P0DPF7	reviewed	TVB63_HUMAN	T cell receptor beta variable 6-3	TRBV6-3	Homo sapiens (Human)	114	FUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]		plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
P0DPI2	reviewed	GAL3A_HUMAN	Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial	GATD3 C21orf33 GATD3A	Homo sapiens (Human)	268				mitochondrion [GO:0005739]		mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
P0DPQ6	reviewed	DT3UO_HUMAN	DDIT3 upstream open reading frame protein (Alternative DDIT3 protein) (AltDDIT3)	DDIT3	Homo sapiens (Human)	34	FUNCTION: [Isoform AltDDIT3]: Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP. {ECO:0000250|UniProtKB:A0A2R8VHR8}.			cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29083303}. Cytoplasm {ECO:0000269|PubMed:29083303}.
P0DQD5	reviewed	NPY42_HUMAN	Neuropeptide Y receptor type 4-2	NPY4R2	Homo sapiens (Human)	375	FUNCTION: G protein-coupled receptor for PPY/pancreatic polypeptide/PP, NPY/neuropeptide Y and PYY/peptide YY that is negatively coupled to cAMP. The rank order of affinity for these polypeptides and their derivatives is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid. {ECO:0000250|UniProtKB:P50391}.		G protein-coupled receptor signaling pathway [GO:0007186]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]	neuropeptide binding [GO:0042923]; pancreatic polypeptide receptor activity [GO:0001602]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; neuropeptide binding [GO:0042923]; pancreatic polypeptide receptor activity [GO:0001602]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50391}; Multi-pass membrane protein {ECO:0000255}.
P0DSN7	reviewed	KVD37_HUMAN	Probable non-functional immunoglobulinn kappa variable 1D-37	IGKV1D-37	Homo sapiens (Human)	117	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		adaptive immune response [GO:0002250]; immune response [GO:0006955]	extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DSO2	reviewed	SCGR9_HUMAN	Small cysteine and glycine repeat-containing protein 9 (Keratin-associated protein 28-1 pseudogene)	SCYGR9 KRTAP28p1	Homo sapiens (Human)	92	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.	MISCELLANEOUS: Human have a similar number of genes as other primates despite the relative hairlessness of humans. {ECO:0000303|PubMed:18721477}.		intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
P0DTE1	reviewed	HV383_HUMAN	Probable non-functional immunoglobulin heavy variable 3-38-3	IGHV3-38-3 IGHV3-D	Homo sapiens (Human)	115	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170, PubMed:22158414, PubMed:24600447). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DTE2	reviewed	HV511_HUMAN	Probable non-functional immunoglobulin heavy variable 8-51-1	IGHV8-51-1	Homo sapiens (Human)	115	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170, PubMed:22158414, PubMed:24600447). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DTL5	reviewed	TM276_HUMAN	Transmembrane protein 276	TMEM276	Homo sapiens (Human)	192				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
P0DTL6	reviewed	ZTRF1_HUMAN	Zinc finger TRAF-type-containing protein 1 (Cysteine and histidine-rich protein 1)	ZFTRAF1 CYHR1 KIAA0496	Homo sapiens (Human)	404				nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]	zinc ion binding [GO:0008270]	nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QXA1}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9QXA1}. Note=Shows a prominent perinuclear and cytoplasmic localization. {ECO:0000250|UniProtKB:Q9QXA1}.
P0DTW3	reviewed	HV384_HUMAN	Probable non-functional immunoglobulin heavy variable 1-38-4	IGHV1-38-4 IGHV1-C	Homo sapiens (Human)	117	FUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:9619395}.		immunoglobulin mediated immune response [GO:0016064]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]	antigen binding [GO:0003823]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; antigen binding [GO:0003823]; immunoglobulin mediated immune response [GO:0016064]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DUH7	reviewed	HRURF_HUMAN	Protein HRURF (HR upstream open reading frame protein)	HRURF U2HR	Homo sapiens (Human)	34	FUNCTION: May function as an inhibitory translational control element that can negatively regulate protein translation of HR gene. {ECO:0000269|PubMed:19122663}.		regulation of translation [GO:0006417]			regulation of translation [GO:0006417]	
P0DV77	reviewed	TPRX2_HUMAN	Tetrapeptide repeat homeobox protein 2	TPRX2	Homo sapiens (Human)	301	FUNCTION: Transcription factor expressed after fertilization required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:27412763, PubMed:36074823). Binds and activates expression of key ZGA marker genes, such as NANOGNB, ZSCAN4, DUXB, KLF5 and DPPA3 (PubMed:36074823). Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif (PubMed:36074823). {ECO:0000269|PubMed:27412763, ECO:0000269|PubMed:36074823}.		maternal-to-zygotic transition of gene expression [GO:0160021]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; maternal-to-zygotic transition of gene expression [GO:0160021]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
P10075	reviewed	GLI4_HUMAN	Zinc finger protein GLI4 (Krueppel-related zinc finger protein 4) (Protein HKR4)	GLI4 HKR4	Homo sapiens (Human)	376			regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P11465	reviewed	PSG2_HUMAN	Pregnancy-specific beta-1-glycoprotein 2 (PS-beta-G-2) (PSBG-2) (Pregnancy-specific glycoprotein 2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E)	PSG2 PSBG2	Homo sapiens (Human)	335			cell migration [GO:0016477]; female pregnancy [GO:0007565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]	cell surface [GO:0009986]; extracellular region [GO:0005576]		cell surface [GO:0009986]; extracellular region [GO:0005576]; cell migration [GO:0016477]; female pregnancy [GO:0007565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P11844	reviewed	CRGA_HUMAN	Gamma-crystallin A (Gamma-A-crystallin) (Gamma-crystallin 5)	CRYGA CRYG1	Homo sapiens (Human)	174	FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.		lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]		structural constituent of eye lens [GO:0005212]	structural constituent of eye lens [GO:0005212]; lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]	
P12525	reviewed	MYCP1_HUMAN	Putative myc-like protein MYCLP1 (Protein L-Myc-2) (V-myc myelocytomatosis viral oncogene homolog pseudogene 1)	MYCLP1 MYCL1P1 MYCL2	Homo sapiens (Human)	358			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
P15421	reviewed	GLPE_HUMAN	Glycophorin-E	GYPE GPE	Homo sapiens (Human)	78	FUNCTION: This protein is a minor sialoglycoprotein in human erythrocyte membranes.			plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
P16415	reviewed	ZN823_HUMAN	Zinc finger protein 823 (Zinc finger protein ZFP-36)	ZNF823 ZFP36	Homo sapiens (Human)	610	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P16562	reviewed	CRIS2_HUMAN	Cysteine-rich secretory protein 2 (CRISP-2) (Cancer/testis antigen 36) (CT36) (Testis-specific protein TPX-1)	CRISP2 GAPDL5 TPX1	Homo sapiens (Human)	243	FUNCTION: May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. {ECO:0000250}.			extracellular space [GO:0005615]		extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P17017	reviewed	ZNF14_HUMAN	Zinc finger protein 14 (Gonadotropin-inducible ovary transcription repressor 4) (GIOT-4) (Zinc finger protein KOX6)	ZNF14 GIOT4 KOX6	Homo sapiens (Human)	642	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P20962	reviewed	PTMS_HUMAN	Parathymosin	PTMS	Homo sapiens (Human)	102	FUNCTION: Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.		DNA replication [GO:0006260]; immune system process [GO:0002376]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleus [GO:0005634]	histone binding [GO:0042393]	nucleus [GO:0005634]; histone binding [GO:0042393]; DNA replication [GO:0006260]; immune system process [GO:0002376]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944]	
P31275	reviewed	HXC12_HUMAN	Homeobox protein Hox-C12 (Homeobox protein Hox-3F)	HOXC12 HOC3F HOX3F	Homo sapiens (Human)	282	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.			nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	SUBCELLULAR LOCATION: Nucleus.
P43359	reviewed	MAGA5_HUMAN	Putative melanoma-associated antigen 5P (Cancer/testis antigen 1.5) (CT1.5) (MAGE family member A5 pseudogene) (MAGE-5 antigen)	MAGEA5P MAGE5 MAGEA5	Homo sapiens (Human)	124	FUNCTION: May negatively regulates apoptosis. {ECO:0000269|PubMed:17942928}.		regulation of chromosome segregation [GO:0051983]			regulation of chromosome segregation [GO:0051983]	
P43362	reviewed	MAGA9_HUMAN	Melanoma-associated antigen 9 (Cancer/testis antigen 1.9) (CT1.9) (MAGE-9 antigen)	MAGEA9 MAGE9 MAGEA9A; MAGEA9B	Homo sapiens (Human)	315	FUNCTION: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	histone deacetylase binding [GO:0042826]	nucleus [GO:0005634]; histone deacetylase binding [GO:0042826]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
P43366	reviewed	MAGB1_HUMAN	Melanoma-associated antigen B1 (Cancer/testis antigen 3.1) (CT3.1) (DSS-AHC critical interval MAGE superfamily 10) (DAM10) (MAGE-B1 antigen) (MAGE-XP antigen)	MAGEB1 MAGEL1 MAGEXP	Homo sapiens (Human)	347			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
P47881	reviewed	OR3A1_HUMAN	Olfactory receptor 3A1 (Olfactory receptor 17-40) (OR17-40) (Olfactory receptor OR17-15)	OR3A1 OLFRA03	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P47884	reviewed	OR1D4_HUMAN	Olfactory receptor 1D4 (Olfactory receptor 17-30) (OR17-30)	OR1D4	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P47890	reviewed	OR1G1_HUMAN	Olfactory receptor 1G1 (Olfactory receptor 17-209) (OR17-209) (Olfactory receptor 1G2) (Olfactory receptor OR17-8)	OR1G1 OR1G2	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P47944	reviewed	MT4_HUMAN	Metallothionein-4 (MT-4) (Metallothionein-IV) (MT-IV)	MT4	Homo sapiens (Human)	62	FUNCTION: Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.		cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]	
P48741	reviewed	HSP77_HUMAN	Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B)	HSPA7 HSP70B	Homo sapiens (Human)	367			chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; ubiquitin protein ligase binding [GO:0031625]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; ubiquitin protein ligase binding [GO:0031625]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026]	
P51523	reviewed	ZNF84_HUMAN	Zinc finger protein 84 (Zinc finger protein HPF2)	ZNF84	Homo sapiens (Human)	738	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P51786	reviewed	ZN157_HUMAN	Zinc finger protein 157 (Zinc finger protein HZF22)	ZNF157	Homo sapiens (Human)	506	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P51861	reviewed	CDR1_HUMAN	Cerebellar degeneration-related antigen 1 (CDR34)	CDR1	Homo sapiens (Human)	262		MISCELLANEOUS: Autoantibodies against CDR1 are found in patients with paraneoplastic cerebellar degeneration.					
P52740	reviewed	ZN132_HUMAN	Zinc finger protein 132	ZNF132	Homo sapiens (Human)	706	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P52743	reviewed	ZN137_HUMAN	Putative zinc finger protein 137 (Zinc finger protein 137 pseudogene)	ZNF137P ZNF137	Homo sapiens (Human)	207	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P52943	reviewed	CRIP2_HUMAN	Cysteine-rich protein 2 (CRP-2) (Protein ESP1)	CRIP2 CRP2	Homo sapiens (Human)	208			hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284]	cell cortex [GO:0005938]	zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; zinc ion binding [GO:0008270]; hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284]	
P55822	reviewed	SH3BG_HUMAN	SH3 domain-binding glutamic acid-rich protein (SH3BGR protein) (21-glutamic acid-rich protein) (21-GARP)	SH3BGR	Homo sapiens (Human)	239				cytoplasm [GO:0005737]	SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; SH3 domain binding [GO:0017124]	
P56749	reviewed	CLD12_HUMAN	Claudin-12	CLDN12	Homo sapiens (Human)	244	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.		calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; maintenance of blood-brain barrier [GO:0035633]	bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]	bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; maintenance of blood-brain barrier [GO:0035633]	SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane {ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}.
P57060	reviewed	RWD2B_HUMAN	RWD domain-containing protein 2B	RWDD2B C21orf6 GL011	Homo sapiens (Human)	319							
P58170	reviewed	OR1D5_HUMAN	Olfactory receptor 1D5 (Olfactory receptor 17-31) (OR17-31)	OR1D5	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P58180	reviewed	OR4D2_HUMAN	Olfactory receptor 4D2 (B-lymphocyte membrane protein BC2009) (Olfactory receptor OR17-24)	OR4D2	Homo sapiens (Human)	307	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P58181	reviewed	O10A3_HUMAN	Olfactory receptor 10A3 (HTPCRX12) (Olfactory receptor OR11-97)	OR10A3	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P58511	reviewed	SIM11_HUMAN	Small integral membrane protein 11	SMIM11 C21orf51 FAM165B SMIM11A	Homo sapiens (Human)	58				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P58549	reviewed	FXYD7_HUMAN	FXYD domain-containing ion transport regulator 7	FXYD7	Homo sapiens (Human)	80			monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269]	plasma membrane [GO:0005886]	sodium channel regulator activity [GO:0017080]	plasma membrane [GO:0005886]; sodium channel regulator activity [GO:0017080]; monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P59536	reviewed	T2R41_HUMAN	Taste receptor type 2 member 41 (T2R41) (Taste receptor type 2 member 59) (T2R59)	TAS2R41	Homo sapiens (Human)	307	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	sensory perception of taste [GO:0050909]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; sensory perception of taste [GO:0050909]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P59539	reviewed	T2R45_HUMAN	Taste receptor type 2 member 45 (T2R45) (G-protein coupled receptor 59)	TAS2R45 GPR59	Homo sapiens (Human)	299	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	sensory perception of taste [GO:0050909]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; sensory perception of taste [GO:0050909]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P59551	reviewed	T2R60_HUMAN	Taste receptor type 2 member 60 (T2R60) (Taste receptor type 2 member 56) (T2R56)	TAS2R60	Homo sapiens (Human)	318	FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.	sensory perception of bitter taste [GO:0050913]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; sensory perception of bitter taste [GO:0050913]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
P59861	reviewed	D131A_HUMAN	Beta-defensin 131A (Beta-defensin 31) (DEFB-31) (Defensin, beta 131)	DEFB131A DEFB131 DEFB31	Homo sapiens (Human)	70	FUNCTION: Has antibacterial activity (Probable). Upon stimulation with lipoteichoic acid, promotes cytokines and chemokines production and secretion (PubMed:26649771). {ECO:0000269|PubMed:26649771, ECO:0000305}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P59922	reviewed	OR2B8_HUMAN	Putative olfactory receptor 2B8 (Hs6M1-29P)	OR2B8P OR2B8	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P60673	reviewed	PROF3_HUMAN	Profilin-3 (Profilin III)	PFN3	Homo sapiens (Human)	137	FUNCTION: Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis. {ECO:0000269|PubMed:19419568}.		actin cytoskeleton organization [GO:0030036]; positive regulation of actin filament bundle assembly [GO:0032233]; regulation of actin filament polymerization [GO:0030833]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]	actin binding [GO:0003779]; lipid binding [GO:0008289]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; actin binding [GO:0003779]; lipid binding [GO:0008289]; actin cytoskeleton organization [GO:0030036]; positive regulation of actin filament bundle assembly [GO:0032233]; regulation of actin filament polymerization [GO:0030833]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}.
P60985	reviewed	KTDAP_HUMAN	Keratinocyte differentiation-associated protein	KRTDAP KDAP UNQ467/PRO826	Homo sapiens (Human)	99	FUNCTION: May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. {ECO:0000269|PubMed:15140226}.		cell differentiation [GO:0030154]; epidermis development [GO:0008544]	extracellular space [GO:0005615]; lamellar body [GO:0042599]		extracellular space [GO:0005615]; lamellar body [GO:0042599]; cell differentiation [GO:0030154]; epidermis development [GO:0008544]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15140226}.
P61129	reviewed	ZC3H6_HUMAN	Zinc finger CCCH domain-containing protein 6	ZC3H6 KIAA2035 ZC3HDC6	Homo sapiens (Human)	1189			macromolecule metabolic process [GO:0043170]; negative regulation of DNA-templated transcription [GO:0045892]	chromatin [GO:0000785]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	chromatin [GO:0000785]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; macromolecule metabolic process [GO:0043170]; negative regulation of DNA-templated transcription [GO:0045892]	
P61236	reviewed	YPEL3_HUMAN	Protein yippee-like 3	YPEL3 FKSG5	Homo sapiens (Human)	119	FUNCTION: Involved in proliferation and apoptosis in myeloid precursor cells. {ECO:0000250}.		positive regulation of cellular senescence [GO:2000774]	nucleolus [GO:0005730]	metal ion binding [GO:0046872]	nucleolus [GO:0005730]; metal ion binding [GO:0046872]; positive regulation of cellular senescence [GO:2000774]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15556292}.
P61570	reviewed	ENK25_HUMAN	Endogenous retrovirus group K member 25 Env polyprotein (Envelope polyprotein) (HERV-K_11q22.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERVK-25	Homo sapiens (Human)	661	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity). {ECO:0000250}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.	MISCELLANEOUS: Has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.		plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: Virion {ECO:0000250}.; SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P62502	reviewed	LCN6_HUMAN	Epididymal-specific lipocalin-6 (Lipocalin-5)	LCN6 LCN5 UNQ643/PRO1273	Homo sapiens (Human)	163	FUNCTION: May play a role in male fertility.		single fertilization [GO:0007338]	extracellular region [GO:0005576]	small molecule binding [GO:0036094]	extracellular region [GO:0005576]; small molecule binding [GO:0036094]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Secreted. Note=Located on the head and tail of spermatozoa with the highest concentration on the post-acrosomal region of the head, where it appears aggregated into large patches.
P62685	reviewed	GAK8_HUMAN	Endogenous retrovirus group K member 8 Gag polyprotein (HERV-K115 Gag protein) (HERV-K_8p23.1 provirus ancestral Gag polyprotein) (Gag polyprotein)	ERVK-8	Homo sapiens (Human)	647	FUNCTION: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: Insertional polymorphism. Provirus present in 16% of tested individuals.; MISCELLANEOUS: Intragenic, in first intron of DEFB107 gene.	viral process [GO:0016032]	plasma membrane [GO:0005886]	nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]; nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; viral process [GO:0016032]	SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.
P63119	reviewed	VPK21_HUMAN	Endogenous retrovirus group K member 21 Pro protein (HERV-K_12q14.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)	ERVK-21	Homo sapiens (Human)	156	FUNCTION: Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.		proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; proteolysis [GO:0006508]	
P63120	reviewed	VPK19_HUMAN	Endogenous retrovirus group K member 19 Pro protein (HERV-K(C19) Pro protein) (HERV-K_19q12 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)	ERVK-19	Homo sapiens (Human)	156	FUNCTION: Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.		proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; proteolysis [GO:0006508]	
P63121	reviewed	VP113_HUMAN	Endogenous retrovirus group K member 113 Pro protein (HERV-K113 envelope protein) (HERV-K_19p13.11 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)	HERVK_113	Homo sapiens (Human)	156	FUNCTION: Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: Insertional polymorphism. Provirus present in 29% of tested individuals.	proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; proteolysis [GO:0006508]	
P63122	reviewed	VPK8_HUMAN	Endogenous retrovirus group K member 8 Pro protein (HERV-K115 Pro protein) (HERV-K_8p23.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)	ERVK-8	Homo sapiens (Human)	156	FUNCTION: Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: Insertional polymorphism. Provirus present in 16% of tested individuals.	proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; proteolysis [GO:0006508]	
P63124	reviewed	VPK04_HUMAN	Endogenous retrovirus group K member 104 Pro protein (HERV-K104 Pro protein) (HERV-K_5q13.3 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)	HERV-K104	Homo sapiens (Human)	156	FUNCTION: Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution (By similarity). {ECO:0000250}.		proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; proteolysis [GO:0006508]	
P63125	reviewed	VPK25_HUMAN	Endogenous retrovirus group K member 25 Pro protein (HERV-K_11q22.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)	ERVK-25	Homo sapiens (Human)	156	FUNCTION: Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein has retained most of the characteristics of retroviral proteases.		proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; proteolysis [GO:0006508]	
P63127	reviewed	VPK9_HUMAN	Endogenous retrovirus group K member 9 Pro protein (HERV-K(C6) Pro protein) (HERV-K109 Pro protein) (HERV-K_6q14.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)	ERVK-9	Homo sapiens (Human)	156	FUNCTION: Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution (By similarity). {ECO:0000250}.		proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; proteolysis [GO:0006508]	
P63131	reviewed	VPK7_HUMAN	Endogenous retrovirus group K member 7 Pro protein (HERV-K(III) Pro protein) (HERV-K102 Pro protein) (HERV-K_1q22 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)	ERVK-7	Homo sapiens (Human)	156	FUNCTION: Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein has retained most of the characteristics of retroviral proteases.		proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; proteolysis [GO:0006508]	
P63302	reviewed	SELW_HUMAN	Selenoprotein W (SelW)	SELENOW SELW SEPW1	Homo sapiens (Human)	87	FUNCTION: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity). {ECO:0000250}.		response to selenium ion [GO:0010269]	cytoplasm [GO:0005737]	antioxidant activity [GO:0016209]	cytoplasm [GO:0005737]; antioxidant activity [GO:0016209]; response to selenium ion [GO:0010269]	SUBCELLULAR LOCATION: Cytoplasm.
P78312	reviewed	F193A_HUMAN	Protein FAM193A (Protein IT14)	FAM193A C4orf8 RES4-22	Homo sapiens (Human)	1265		MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
P82664	reviewed	RT10_HUMAN	Small ribosomal subunit protein uS10m (28S ribosomal protein S10, mitochondrial) (MRP-S10) (S10mt)	MRPS10 MSTP040	Homo sapiens (Human)	201			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
P82909	reviewed	KGD4_HUMAN	Alpha-ketoglutarate dehydrogenase component 4	MRPS36 KGD4 DC47	Homo sapiens (Human)	103	FUNCTION: May be necessary to recruit DLD/E3 to the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDC) core composed of OGDH/E1-DLST/E2, hence stabilizes the complex. {ECO:0000250|UniProtKB:Q9CQX8}.		2-oxoglutarate metabolic process [GO:0006103]; tricarboxylic acid cycle [GO:0006099]	mitochondrial inner membrane [GO:0005743]; mitochondrial oxoglutarate dehydrogenase complex [GO:0009353]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrial oxoglutarate dehydrogenase complex [GO:0009353]; mitochondrion [GO:0005739]; 2-oxoglutarate metabolic process [GO:0006103]; tricarboxylic acid cycle [GO:0006099]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P82908}.
P84157	reviewed	MXRA7_HUMAN	Matrix-remodeling-associated protein 7	MXRA7	Homo sapiens (Human)	204				collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]		collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P86790	reviewed	CCZ1B_HUMAN	Vacuolar fusion protein CCZ1 homolog B (Vacuolar fusion protein CCZ1 homolog-like)	CCZ1B C7orf28B	Homo sapiens (Human)	482			vesicle-mediated transport [GO:0016192]	intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658]		intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319}.
P98182	reviewed	ZN200_HUMAN	Zinc finger protein 200	ZNF200 ZNFMF	Homo sapiens (Human)	395	FUNCTION: Could have a role in spermatogenesis.			nucleus [GO:0005634]	metal ion binding [GO:0046872]	nucleus [GO:0005634]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q008S8	reviewed	ECT2L_HUMAN	Epithelial cell-transforming sequence 2 oncogene-like (Lung-specific F-box and DH domain-containing protein) (Putative guanine nucleotide exchange factor LFDH)	ECT2L C6orf91 LFDH	Homo sapiens (Human)	904	FUNCTION: May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.				guanyl-nucleotide exchange factor activity [GO:0005085]	guanyl-nucleotide exchange factor activity [GO:0005085]	
Q02325	reviewed	PLGB_HUMAN	Plasminogen-like protein B (Plasminogen-related protein B)	PLGLB1 PLGL PRGB; PLGLB2 PLGP1	Homo sapiens (Human)	96	FUNCTION: May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.			extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted.
Q03924	reviewed	ZN117_HUMAN	Zinc finger protein 117 (Provirus-linked krueppel) (h-PLK) (Zinc finger protein HPF9)	ZNF117	Homo sapiens (Human)	483	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q03938	reviewed	ZNF90_HUMAN	Zinc finger protein 90 (Zinc finger protein HTF9)	ZNF90	Homo sapiens (Human)	601	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q05BV3	reviewed	EMAL5_HUMAN	Echinoderm microtubule-associated protein-like 5 (EMAP-5)	EML5	Homo sapiens (Human)	1969	FUNCTION: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]	microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; microtubule binding [GO:0008017]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
Q05DH4	reviewed	FHI1A_HUMAN	FHF complex subunit HOOK-interacting protein 1A (FHIP1A) (FTS- and Hook-interacting protein like) (FHIP-L)	FHIP1A FAM160A1	Homo sapiens (Human)	1040	FUNCTION: Probable component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:32073997). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:32073997}.		protein localization to perinuclear region of cytoplasm [GO:1905719]			protein localization to perinuclear region of cytoplasm [GO:1905719]	
Q06250	reviewed	WIT1_HUMAN	Putative Wilms tumor upstream neighbor 1 gene protein (WIT-1) (Wilms tumor-associated antisense RNA)	WT1-AS WIT1	Homo sapiens (Human)	92							
Q075Z2	reviewed	BSPH1_HUMAN	Binder of sperm protein homolog 1 (Bovine seminal plasma protein homolog 1) (Bovine seminal plasma protein-like 1)	BSPH1	Homo sapiens (Human)	132	FUNCTION: Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B. {ECO:0000250|UniProtKB:Q3UW26}.		single fertilization [GO:0007338]; sperm capacitation [GO:0048240]	cell surface [GO:0009986]; extracellular region [GO:0005576]	heparin binding [GO:0008201]	cell surface [GO:0009986]; extracellular region [GO:0005576]; heparin binding [GO:0008201]; single fertilization [GO:0007338]; sperm capacitation [GO:0048240]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q08AF3	reviewed	SLFN5_HUMAN	Schlafen family member 5	SLFN5	Homo sapiens (Human)	891	FUNCTION: May have a role in hematopoietic cell differentiation. {ECO:0000250}.		cell differentiation [GO:0030154]	nucleus [GO:0005634]	ATP binding [GO:0005524]	nucleus [GO:0005634]; ATP binding [GO:0005524]; cell differentiation [GO:0030154]	
Q08AI6	reviewed	S38AB_HUMAN	Putative sodium-coupled neutral amino acid transporter 11 (Solute carrier family 38 member 11)	SLC38A11 AVT2	Homo sapiens (Human)	406	FUNCTION: Putative sodium-dependent amino acid/proton antiporter. {ECO:0000305}.		amino acid transmembrane transport [GO:0003333]; sodium ion transport [GO:0006814]	membrane [GO:0016020]	L-amino acid transmembrane transporter activity [GO:0015179]	membrane [GO:0016020]; L-amino acid transmembrane transporter activity [GO:0015179]; amino acid transmembrane transport [GO:0003333]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q08AN1	reviewed	ZN616_HUMAN	Zinc finger protein 616	ZNF616	Homo sapiens (Human)	781	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q09019	reviewed	DMWD_HUMAN	Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9)	DMWD DM9	Homo sapiens (Human)	674				cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]		cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]	SUBCELLULAR LOCATION: Perikaryon {ECO:0000250|UniProtKB:Q08274}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q08274}. Nucleus {ECO:0000250|UniProtKB:Q08274}. Note=In neurons, shows punctate expression throughout the cell body, nucleus and dendrites. Not detected in axons. {ECO:0000250|UniProtKB:Q08274}.
Q09MP3	reviewed	R51A2_HUMAN	RAD51-associated protein 2	RAD51AP2	Homo sapiens (Human)	1159				protein-containing complex [GO:0032991]		protein-containing complex [GO:0032991]	
Q0P651	reviewed	ABD18_HUMAN	Protein ABHD18 (Alpha/beta hydrolase domain-containing protein 18) (Abhydrolase domain-containing protein 18)	ABHD18 C4orf29	Homo sapiens (Human)	414				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q0P6D2	reviewed	DIK1C_HUMAN	Divergent protein kinase domain 1C (Protein FAM69C)	DIPK1C C18orf51 FAM69C	Homo sapiens (Human)	419				endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BQT2}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8BQT2}.
Q0VDE8	reviewed	ADIG_HUMAN	Adipogenin	ADIG	Homo sapiens (Human)	80	FUNCTION: Plays a role in stimulating adipocyte differentiation and development. {ECO:0000250|UniProtKB:Q8R400}.		brown fat cell differentiation [GO:0050873]; positive regulation of fat cell differentiation [GO:0045600]; spermatogenesis [GO:0007283]; white fat cell differentiation [GO:0050872]	cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleus [GO:0005634]; brown fat cell differentiation [GO:0050873]; positive regulation of fat cell differentiation [GO:0045600]; spermatogenesis [GO:0007283]; white fat cell differentiation [GO:0050872]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000250}.
Q0VDG4	reviewed	SCRN3_HUMAN	Secernin-3	SCRN3	Homo sapiens (Human)	424			proteolysis [GO:0006508]		cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805]	cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805]; proteolysis [GO:0006508]	
Q0VFZ6	reviewed	CF210_HUMAN	Cilia- and flagella- associated protein 210 (Coiled-coil domain-containing protein 173)	CFAP210 C2orf77 CCDC173	Homo sapiens (Human)	552	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.			axonemal microtubule [GO:0005879]		axonemal microtubule [GO:0005879]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q0VGE8	reviewed	ZN816_HUMAN	Zinc finger protein 816	ZNF816 ZNF816A	Homo sapiens (Human)	651	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q107X0	reviewed	KRIP1_HUMAN	Putative protein KRIP1 (Kallikrein-related in prostate protein 1) (Kallikrein-related mRNA protein) (KARMA)	KLKP1 KLK31P	Homo sapiens (Human)	134				cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18196551}. Nucleus {ECO:0000269|PubMed:18196551}.
Q12767	reviewed	TMM94_HUMAN	Transmembrane protein 94	TMEM94 KIAA0195	Homo sapiens (Human)	1356				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q13046	reviewed	PSG7_HUMAN	Pregnancy-specific beta-1-glycoprotein 7 (PS-beta-G-7) (PSBG-7) (Pregnancy-specific glycoprotein 7)	PSG7	Homo sapiens (Human)	419			female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	protein tyrosine kinase binding [GO:1990782]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein tyrosine kinase binding [GO:1990782]; female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q13066	reviewed	GAG2B_HUMAN	G antigen 2B/2C (GAGE-2B) (GAGE-2C) (Cancer/testis antigen 4.2) (CT4.2) (G antigen 2C)	GAGE2B GAGE2; GAGE2C	Homo sapiens (Human)	116	FUNCTION: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.	MISCELLANEOUS: This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
Q13069	reviewed	GAGE5_HUMAN	G antigen 5 (GAGE-5) (Cancer/testis antigen 4.5) (CT4.5)	GAGE5	Homo sapiens (Human)	117		MISCELLANEOUS: This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
Q13072	reviewed	BAGE1_HUMAN	B melanoma antigen 1 (B melanoma antigen) (Antigen MZ2-BA) (Cancer/testis antigen 2.1) (CT2.1)	BAGE BAGE1	Homo sapiens (Human)	43	FUNCTION: Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.	MISCELLANEOUS: The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.		extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q13296	reviewed	SG2A2_HUMAN	Mammaglobin-A (Mammaglobin-1) (Secretoglobin family 2A member 2)	SCGB2A2 MGB1 UGB2	Homo sapiens (Human)	93			androgen receptor signaling pathway [GO:0030521]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; androgen receptor signaling pathway [GO:0030521]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q13536	reviewed	CROC4_HUMAN	Protein CROC-4 (Contingent replication of cDNA 4) (MIR9-1 host gene)	MIR9-1HG C1orf61 CROC4	Homo sapiens (Human)	156	FUNCTION: May play a role in FOS signaling pathways involved in development and remodeling of neurons. Promotes transcription of the FOS promoter. {ECO:0000269|PubMed:10995546}.		positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleus [GO:0005634]		nucleus [GO:0005634]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10995546}. Note=Associates within the nuclear transcriptional apparatus during proliferation and differentiation.
Q14146	reviewed	URB2_HUMAN	Unhealthy ribosome biogenesis protein 2 homolog	URB2 KIAA0133	Homo sapiens (Human)	1524	FUNCTION: Essential for hematopietic stem cell development through the regulation of p53/TP53 pathway. {ECO:0000250|UniProtKB:B0V0U5}.		regulation of signal transduction by p53 class mediator [GO:1901796]; ribosome biogenesis [GO:0042254]	aggresome [GO:0016235]; midbody [GO:0030496]; nucleolus [GO:0005730]		aggresome [GO:0016235]; midbody [GO:0030496]; nucleolus [GO:0005730]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15635413}.
Q14390	reviewed	GGTL2_HUMAN	Glutathione hydrolase light chain 2 (Gamma-glutamyltransferase light chain 2) (Gamma-glutamyltransferase-like protein 4)	GGTLC2 GGTL4	Homo sapiens (Human)	218		MISCELLANEOUS: Corresponds to the light chain of other gamma-glutamyltransferase family members. Has no catalytic activity.	glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]	extracellular exosome [GO:0070062]	glutathione hydrolase activity [GO:0036374]	extracellular exosome [GO:0070062]; glutathione hydrolase activity [GO:0036374]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]	
Q14507	reviewed	EP3A_HUMAN	Epididymal secretory protein E3-alpha (Human epididymis-specific protein 3-alpha) (HE3-alpha)	EDDM3A FAM12A HE3A	Homo sapiens (Human)	147	FUNCTION: Possible function in sperm maturation.		sperm displacement [GO:0007321]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; sperm displacement [GO:0007321]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q14549	reviewed	GBX1_HUMAN	Homeobox protein GBX-1 (Gastrulation and brain-specific homeobox protein 1)	GBX1	Homo sapiens (Human)	363			adult walking behavior [GO:0007628]; neuron fate commitment [GO:0048663]; proprioception [GO:0019230]; regulation of nervous system development [GO:0051960]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory neuron axon guidance [GO:0097374]; spinal cord motor neuron differentiation [GO:0021522]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; adult walking behavior [GO:0007628]; neuron fate commitment [GO:0048663]; proprioception [GO:0019230]; regulation of nervous system development [GO:0051960]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory neuron axon guidance [GO:0097374]; spinal cord motor neuron differentiation [GO:0021522]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q14582	reviewed	MAD4_HUMAN	Max dimerization protein 4 (Max dimerizer 4) (Class C basic helix-loop-helix protein 12) (bHLHc12) (Max-associated protein 4) (Max-interacting transcriptional repressor MAD4)	MXD4 BHLHC12 MAD4	Homo sapiens (Human)	209	FUNCTION: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q14586	reviewed	ZN267_HUMAN	Zinc finger protein 267 (Zinc finger protein HZF2)	ZNF267	Homo sapiens (Human)	743	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q14588	reviewed	ZN234_HUMAN	Zinc finger protein 234 (Zinc finger protein 269) (Zinc finger protein HZF4)	ZNF234 ZNF269	Homo sapiens (Human)	700	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q14761	reviewed	PTCA_HUMAN	Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein)	PTPRCAP LPAP	Homo sapiens (Human)	206			defense response [GO:0006952]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; defense response [GO:0006952]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q147U1	reviewed	ZN846_HUMAN	Zinc finger protein 846	ZNF846	Homo sapiens (Human)	533	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q14DG7	reviewed	T132B_HUMAN	Transmembrane protein 132B	TMEM132B KIAA1786 KIAA1906	Homo sapiens (Human)	1078				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q15032	reviewed	R3HD1_HUMAN	R3H domain-containing protein 1	R3HDM1 KIAA0029 R3HDM	Homo sapiens (Human)	1099					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q15270	reviewed	NKX11_HUMAN	NK1 transcription factor-related protein 1 (Homeobox protein 153) (HPX-153) (Homeobox protein SAX-2) (NKX-1.1)	NKX1-1 HPX153 SAX2	Homo sapiens (Human)	448	FUNCTION: May be required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis, possibly by regulating the transcription of specific factors involved in energy balance. {ECO:0000250|UniProtKB:G3UXB3}.		cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q15434	reviewed	RBMS2_HUMAN	RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3)	RBMS2 SCR3	Homo sapiens (Human)	407			RNA processing [GO:0006396]	cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; RNA processing [GO:0006396]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q15486	reviewed	GUSP1_HUMAN	Putative inactive beta-glucuronidase-like protein SMA3	GUSBP1 SMA3	Homo sapiens (Human)	140			nervous system development [GO:0007399]; skeletal system development [GO:0001501]			nervous system development [GO:0007399]; skeletal system development [GO:0001501]	
Q15527	reviewed	SURF2_HUMAN	Surfeit locus protein 2 (Surf-2)	SURF2	Homo sapiens (Human)	256				nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]		nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	
Q15615	reviewed	OR4D1_HUMAN	Olfactory receptor 4D1 (Olfactory receptor 4D3) (Olfactory receptor TPCR16)	OR4D1 OR4D3	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q15619	reviewed	OR1C1_HUMAN	Olfactory receptor 1C1 (Olfactory receptor OR1-42) (Olfactory receptor TPCR27)	OR1C1	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q15622	reviewed	OR7A5_HUMAN	Olfactory receptor 7A5 (Olfactory receptor OR19-17) (Olfactory receptor TPCR92)	OR7A5	Homo sapiens (Human)	319	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q16048	reviewed	MCHL1_HUMAN	Putative pro-MCH-like protein 1 (Pro-MCH variant) (Pro-melanin-concentrating hormone-like protein 1)	PMCHL1	Homo sapiens (Human)	86			chemical synaptic transmission [GO:0007268]	extracellular region [GO:0005576]; synapse [GO:0045202]	melanin-concentrating hormone activity [GO:0030354]; type 1 melanin-concentrating hormone receptor binding [GO:0031777]	extracellular region [GO:0005576]; synapse [GO:0045202]; melanin-concentrating hormone activity [GO:0030354]; type 1 melanin-concentrating hormone receptor binding [GO:0031777]; chemical synaptic transmission [GO:0007268]	
Q16517	reviewed	NNAT_HUMAN	Neuronatin	NNAT	Homo sapiens (Human)	81	FUNCTION: May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels.		brain development [GO:0007420]; positive regulation of insulin secretion [GO:0032024]; protein lipoylation [GO:0009249]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; brain development [GO:0007420]; positive regulation of insulin secretion [GO:0032024]; protein lipoylation [GO:0009249]	
Q16559	reviewed	TAL2_HUMAN	T-cell acute lymphocytic leukemia protein 2 (TAL-2) (Class A basic helix-loop-helix protein 19) (bHLHa19)	TAL2 BHLHA19	Homo sapiens (Human)	108			midbrain development [GO:0030901]; multicellular organism growth [GO:0035264]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; thalamus development [GO:0021794]	chromatin [GO:0000785]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; midbrain development [GO:0030901]; multicellular organism growth [GO:0035264]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; thalamus development [GO:0021794]	
Q16609	reviewed	LPAL2_HUMAN	Putative apolipoprotein(a)-like protein 2 (Apo(a)-like protein 2) (Lp(a)-liker protein 2) (Apolipoprotein a-related gene C protein) (Apo(a)rg-C)	LPAL2 APOARGC	Homo sapiens (Human)	132				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q16626	reviewed	MEA1_HUMAN	Male-enhanced antigen 1 (MEA-1)	MEA1 MEA	Homo sapiens (Human)	185	FUNCTION: May play an important role in spermatogenesis and/or testis development.		cell differentiation [GO:0030154]; male gonad development [GO:0008584]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; cell differentiation [GO:0030154]; male gonad development [GO:0008584]; spermatogenesis [GO:0007283]	
Q17R31	reviewed	TATD3_HUMAN	Putative deoxyribonuclease TATDN3 (EC 3.1.21.-)	TATDN3	Homo sapiens (Human)	274	FUNCTION: Putative deoxyribonuclease.			nucleus [GO:0005634]	metal ion binding [GO:0046872]; nuclease activity [GO:0004518]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q17R55	reviewed	F187B_HUMAN	Protein FAM187B (Transmembrane protein 162)	FAM187B TMEM162	Homo sapiens (Human)	369				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q17RC7	reviewed	EX3L4_HUMAN	Exocyst complex component 3-like protein 4	EXOC3L4 C14orf73	Homo sapiens (Human)	722			exocyst localization [GO:0051601]; exocytosis [GO:0006887]	exocyst [GO:0000145]	SNARE binding [GO:0000149]	exocyst [GO:0000145]; SNARE binding [GO:0000149]; exocyst localization [GO:0051601]; exocytosis [GO:0006887]	
Q17RG1	reviewed	KCD19_HUMAN	BTB/POZ domain-containing protein KCTD19 (Potassium channel tetramerization domain-containing protein 19)	KCTD19	Homo sapiens (Human)	926	FUNCTION: Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes. Regulates progression of the pachytene stage of meiotic prophase and promotes the transcriptional activation activity ZNF541. Required for the organization of chromosomes during metaphase I. {ECO:0000250|UniProtKB:Q562E2}.		cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; protein homooligomerization [GO:0051260]; spermatogenesis [GO:0007283]	nucleus [GO:0005634]		nucleus [GO:0005634]; cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; protein homooligomerization [GO:0051260]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q562E2}.
Q17RH7	reviewed	TPRXL_HUMAN	Tetra-peptide repeat homeobox-like protein	TPRXL	Homo sapiens (Human)	139	FUNCTION: Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:36074823). Protein produced from maternal transcripts that binds and activates expression of key ZGA marker genes, such as NANOGNB, ZSCAN4, DUXB, KLF5 and DPPA3 (PubMed:36074823). Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif (By similarity). {ECO:0000250|UniProtKB:Q8N7U7, ECO:0000269|PubMed:36074823}.		maternal-to-zygotic transition of gene expression [GO:0160021]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; maternal-to-zygotic transition of gene expression [GO:0160021]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:36074823}.
Q17RR3	reviewed	LIPR3_HUMAN	Pancreatic lipase-related protein 3 (PL-RP3) (EC 3.1.1.3)	PNLIPRP3	Homo sapiens (Human)	467			lipid catabolic process [GO:0016042]	extracellular region [GO:0005576]	triglyceride lipase activity [GO:0004806]	extracellular region [GO:0005576]; triglyceride lipase activity [GO:0004806]; lipid catabolic process [GO:0016042]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q1AE95	reviewed	T183B_HUMAN	Putative transmembrane protein 183BP (Transmembrane protein 183B pseudogene)	TMEM183BP C1orf37-dup TMEM183B	Homo sapiens (Human)	376		MISCELLANEOUS: This gene was derived from TMEM183A through retroposition after the divergence of human and chimpanzee. {ECO:0000305|PubMed:16644869}.	regulation of protein stability [GO:0031647]	membrane [GO:0016020]; SCF ubiquitin ligase complex [GO:0019005]		membrane [GO:0016020]; SCF ubiquitin ligase complex [GO:0019005]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q1ED39	reviewed	KNOP1_HUMAN	Lysine-rich nucleolar protein 1 (Protein FAM191A) (Testis-specific gene 118 protein)	KNOP1 C16orf88 FAM191A TSG118	Homo sapiens (Human)	458				nucleolus [GO:0005730]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
Q1KMD3	reviewed	HNRL2_HUMAN	Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2)	HNRNPUL2 HNRPUL2	Homo sapiens (Human)	747				membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]	RNA binding [GO:0003723]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q00PI9}.
Q1W4C9	reviewed	ISK13_HUMAN	Serine protease inhibitor Kazal-type 13 (Hepatitis B virus DNA polymerase transactivated serine protease inhibitor) (Hespintor) (Serine protease inhibitor Kazal-type 5-like 3)	SPINK13 HBVDNAPTP1 SPINK5L3	Homo sapiens (Human)	94	FUNCTION: May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity). {ECO:0000250}.		negative regulation of acrosome reaction [GO:1902225]	extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of acrosome reaction [GO:1902225]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted into the lumen of the initial segment of the epididymis and binds to sperm. In the initial segment of epididymis, localizes on the dorsal surface of the acrosomal region of sperm, gradually becomes more restricted to the acrosomal region in spermatozoa during epididymal transit (By similarity). {ECO:0000250}.
Q1X8D7	reviewed	LRC36_HUMAN	Leucine-rich repeat-containing protein 36 (ROR gamma-binding protein 70)	LRRC36 RORBP70	Homo sapiens (Human)	754							
Q1XH10	reviewed	SKDA1_HUMAN	SKI/DACH domain-containing protein 1 (Protein DLN-1)	SKIDA1 C10orf140 DLN1	Homo sapiens (Human)	908			regulation of transcription by RNA polymerase II [GO:0006357]		DNA-binding transcription factor activity [GO:0003700]	DNA-binding transcription factor activity [GO:0003700]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q1ZYL8	reviewed	IZUM4_HUMAN	Izumo sperm-egg fusion protein 4 (Sperm 22 kDa protein c113)	IZUMO4 C19orf36 UNQ831/PRO1758	Homo sapiens (Human)	232		MISCELLANEOUS: Izumo is the name of a Japanese shrine to marriage.		extracellular region [GO:0005576]; nucleus [GO:0005634]		extracellular region [GO:0005576]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q24JQ0	reviewed	TM241_HUMAN	Transmembrane protein 241	TMEM241 C18orf45	Homo sapiens (Human)	296		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		Golgi apparatus [GO:0005794]; membrane [GO:0016020]	antiporter activity [GO:0015297]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; antiporter activity [GO:0015297]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q2KHR3	reviewed	QSER1_HUMAN	Glutamine and serine-rich protein 1	QSER1	Homo sapiens (Human)	1735	FUNCTION: Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}.			chromosome [GO:0005694]		chromosome [GO:0005694]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:33833093}.
Q2M218	reviewed	ZN630_HUMAN	Zinc finger protein 630	ZNF630	Homo sapiens (Human)	657	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q2M296	reviewed	MTHSD_HUMAN	Methenyltetrahydrofolate synthase domain-containing protein	MTHFSD	Homo sapiens (Human)	383				cytoplasm [GO:0005737]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; RNA binding [GO:0003723]	
Q2M2I3	reviewed	FA83E_HUMAN	Protein FAM83E	FAM83E	Homo sapiens (Human)	478	FUNCTION: May play a role in MAPK signaling. {ECO:0000303|PubMed:24736947}.		signal transduction [GO:0007165]		protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]; signal transduction [GO:0007165]	
Q2M2W7	reviewed	CQ058_HUMAN	UPF0450 protein C17orf58	C17orf58	Homo sapiens (Human)	339				collagen-containing extracellular matrix [GO:0062023]		collagen-containing extracellular matrix [GO:0062023]	
Q2M3D2	reviewed	EX3L2_HUMAN	Exocyst complex component 3-like protein 2 (HBV X-transactivated gene 7 protein) (HBV XAg-transactivated protein 7)	EXOC3L2 XTP7	Homo sapiens (Human)	409			exocytosis [GO:0006887]	exocyst [GO:0000145]		exocyst [GO:0000145]; exocytosis [GO:0006887]	
Q2M3V2	reviewed	SWAHA_HUMAN	Ankyrin repeat domain-containing protein SOWAHA (Ankyrin repeat domain-containing protein 43) (Protein sosondowah homolog A)	SOWAHA ANKRD43	Homo sapiens (Human)	549							
Q2M3W8	reviewed	ZN181_HUMAN	Zinc finger protein 181 (HHZ181)	ZNF181	Homo sapiens (Human)	571	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q2M5E4	reviewed	RGS21_HUMAN	Regulator of G-protein signaling 21 (RGS21)	RGS21	Homo sapiens (Human)	152	FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. {ECO:0000250}.		G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917]; transmission of nerve impulse [GO:0019226]	plasma membrane [GO:0005886]	GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917]; transmission of nerve impulse [GO:0019226]	
Q2PZI1	reviewed	D19L1_HUMAN	Probable C-mannosyltransferase DPY19L1 (EC 2.4.1.-) (Dpy-19-like protein 1) (Protein dpy-19 homolog 1)	DPY19L1 GA0500 KIAA0877	Homo sapiens (Human)	675	FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. {ECO:0000250}.	MISCELLANEOUS: It has been suggested that DPY19L1 has a related pseudogene DPY19L1P1.		membrane [GO:0016020]; nuclear inner membrane [GO:0005637]	mannosyltransferase activity [GO:0000030]	membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; mannosyltransferase activity [GO:0000030]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q2QD12	reviewed	RPEL1_HUMAN	Ribulose-phosphate 3-epimerase-like protein 1 (EC 5.1.3.1) (Ribulose-5-phosphate-3-epimerase-like protein 1)	RPEL1	Homo sapiens (Human)	228	FUNCTION: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. {ECO:0000250|UniProtKB:Q96AT9}.	MISCELLANEOUS: According to some authors, RPEL1 is a RPE retrogene on chromosome 2 which is likely to be functional. {ECO:0000305|PubMed:16201836}.	carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]	cytosol [GO:0005829]	D-ribulose-phosphate 3-epimerase activity [GO:0004750]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; D-ribulose-phosphate 3-epimerase activity [GO:0004750]; metal ion binding [GO:0046872]; carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]	
Q2TAA2	reviewed	IAH1_HUMAN	Isoamyl acetate-hydrolyzing esterase 1 homolog (EC 3.1.-.-)	IAH1	Homo sapiens (Human)	248	FUNCTION: Probable lipase. {ECO:0000250}.		lipid catabolic process [GO:0016042]		hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]	hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; lipid catabolic process [GO:0016042]	
Q2TAA8	reviewed	TXIP1_HUMAN	Translin-associated factor X-interacting protein 1 (Trax-interacting protein 1)	TSNAXIP1 TXI1	Homo sapiens (Human)	658	FUNCTION: Possible role in spermatogenesis. {ECO:0000250|UniProtKB:Q99P25}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]		cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q99P25}.
Q2TAL5	reviewed	SMTL2_HUMAN	Smoothelin-like protein 2	SMTNL2	Homo sapiens (Human)	461			actin cytoskeleton organization [GO:0030036]	filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815]		filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815]; actin cytoskeleton organization [GO:0030036]	
Q2TB10	reviewed	ZN800_HUMAN	Zinc finger protein 800	ZNF800 PP902	Homo sapiens (Human)	664	FUNCTION: May be involved in transcriptional regulation.		acinar cell differentiation [GO:0090425]; endocrine pancreas development [GO:0031018]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; acinar cell differentiation [GO:0090425]; endocrine pancreas development [GO:0031018]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q2TBF2	reviewed	WSCD2_HUMAN	Sialate:O-sulfotransferase 2 (WSC domain-containing protein 2)	WSCD2 KIAA0789	Homo sapiens (Human)	565	FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. {ECO:0000250|UniProtKB:D4PHA7}.			Golgi membrane [GO:0000139]	sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; sulfotransferase activity [GO:0008146]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:D4PHA7}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:D4PHA7}.
Q2TV78	reviewed	MST1L_HUMAN	Putative macrophage stimulating 1-like protein (Brain rescue factor 1) (BRF-1) (Hepatocyte growth factor-like protein homolog)	MST1L D1F15S1A MST1P9 MSTP9	Homo sapiens (Human)	715			proteolysis [GO:0006508]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	extracellular space [GO:0005615]	peptidase activity [GO:0008233]; receptor tyrosine kinase binding [GO:0030971]	extracellular space [GO:0005615]; peptidase activity [GO:0008233]; receptor tyrosine kinase binding [GO:0030971]; proteolysis [GO:0006508]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q2VY69	reviewed	ZN284_HUMAN	Zinc finger protein 284	ZNF284 ZNF284L	Homo sapiens (Human)	593	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q2VYF4	reviewed	LETM2_HUMAN	LETM1 domain-containing protein LETM2, mitochondrial (LETM1 and EF-hand domain-containing protein 2) (Leucine zipper-EF-hand-containing transmembrane protein 1-like)	LETM2	Homo sapiens (Human)	491				mitochondrial inner membrane [GO:0005743]	ribosome binding [GO:0043022]	mitochondrial inner membrane [GO:0005743]; ribosome binding [GO:0043022]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q2WGJ8	reviewed	TM249_HUMAN	Cation channel sperm-associated auxiliary subunit TMEM249 (Transmembrane protein 249)	TMEM249 C8orfK29	Homo sapiens (Human)	235	FUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. {ECO:0000250|UniProtKB:A0A2R8VHF7}.			CatSper complex [GO:0036128]; sperm principal piece [GO:0097228]		CatSper complex [GO:0036128]; sperm principal piece [GO:0097228]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:A0A2R8VHF7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A2R8VHF7}. Note=Predominantly located in the principal piece of the sperm tail. {ECO:0000250|UniProtKB:A0A2R8VHF7}.
Q2WGJ9	reviewed	FR1L6_HUMAN	Fer-1-like protein 6	FER1L6 C8orfK23	Homo sapiens (Human)	1857			positive regulation of gene expression [GO:0010628]; response to bacterium [GO:0009617]	membrane [GO:0016020]	metal ion binding [GO:0046872]	membrane [GO:0016020]; metal ion binding [GO:0046872]; positive regulation of gene expression [GO:0010628]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q2WGN9	reviewed	GAB4_HUMAN	GRB2-associated-binding protein 4 (GRB2-associated binder 2-like) (GAB2-like) (GRB2-associated binder 4) (GRB2-associated-binding protein 2-like) (Growth factor receptor bound protein 2-associated protein 4)	GAB4	Homo sapiens (Human)	574			signal transduction [GO:0007165]	cytoplasm [GO:0005737]	transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	cytoplasm [GO:0005737]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; signal transduction [GO:0007165]	
Q30KQ1	reviewed	DB133_HUMAN	Beta-defensin 133 (Defensin, beta 133)	DEFB133	Homo sapiens (Human)	61	FUNCTION: Has antibacterial activity. {ECO:0000305}.		cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular space [GO:0005615]	CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]	extracellular space [GO:0005615]; CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]; cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q30KQ4	reviewed	DB116_HUMAN	Beta-defensin 116 (Beta-defensin 16) (DEFB-16) (Defensin, beta 116)	DEFB116 DEFB16	Homo sapiens (Human)	102	FUNCTION: Has antibacterial activity. {ECO:0000250}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q30KQ5	reviewed	DB115_HUMAN	Beta-defensin 115 (Beta-defensin 15) (DEFB-15) (Defensin, beta 115)	DEFB115 DEFB15	Homo sapiens (Human)	88	FUNCTION: Has antibacterial activity. {ECO:0000250}.		defense response to bacterium [GO:0042742]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q30KQ8	reviewed	DB112_HUMAN	Beta-defensin 112 (Beta-defensin 12) (DEFB-12) (Defensin, beta 112)	DEFB112 DEFB12	Homo sapiens (Human)	113	FUNCTION: Has antibacterial activity. {ECO:0000250}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q30KR1	reviewed	DB109_HUMAN	Putative beta-defensin 109B (Defensin, beta 109, pseudogene 1B) (Defensin, beta 109B)	DEFB109B DEFB109P1B	Homo sapiens (Human)	87	FUNCTION: Has antibacterial activity. {ECO:0000250}.		cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]	extracellular space [GO:0005615]	CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]	extracellular space [GO:0005615]; CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056]; cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q32P51	reviewed	RA1L2_HUMAN	Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2)	HNRNPA1L2 HNRNPA1L	Homo sapiens (Human)	320	FUNCTION: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}.		mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]	mRNA 3'-UTR binding [GO:0003730]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; mRNA 3'-UTR binding [GO:0003730]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q3B7J2	reviewed	GFOD2_HUMAN	Glucose-fructose oxidoreductase domain-containing protein 2 (EC 1.-.-.-)	GFOD2 UNQ9430/PRO34691	Homo sapiens (Human)	385	FUNCTION: Promotes matrix assembly. {ECO:0000250}.		extracellular matrix organization [GO:0030198]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491]; extracellular matrix organization [GO:0030198]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q3B7T3	reviewed	BEAN1_HUMAN	Protein BEAN1 (Brain-expressed protein associating with Nedd4 homolog) (BEAN)	BEAN1	Homo sapiens (Human)	259				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q3B8N5	reviewed	PROX2_HUMAN	Prospero homeobox protein 2 (Homeobox prospero-like protein PROX2) (PROX-2)	PROX2	Homo sapiens (Human)	592	FUNCTION: Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). {ECO:0000250}.		cell development [GO:0048468]; regulation of transcription by RNA polymerase II [GO:0006357]; system development [GO:0048731]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell development [GO:0048468]; regulation of transcription by RNA polymerase II [GO:0006357]; system development [GO:0048731]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q3C1V8	reviewed	BSH_HUMAN	Brain-specific homeobox protein homolog	BSX BSX1	Homo sapiens (Human)	233	FUNCTION: DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance (By similarity). {ECO:0000250}.		eating behavior [GO:0042755]; locomotory behavior [GO:0007626]; mammary gland involution [GO:0060056]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; eating behavior [GO:0042755]; locomotory behavior [GO:0007626]; mammary gland involution [GO:0060056]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q810B3}.
Q3KNT7	reviewed	NSN5B_HUMAN	Putative NOL1/NOP2/Sun domain family member 5B (EC 2.1.1.-) (Williams-Beuren syndrome chromosomal region 20B protein)	NSUN5P1 NSUN5B WBSCR20B	Homo sapiens (Human)	163			rRNA base methylation [GO:0070475]	nucleolus [GO:0005730]	RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	nucleolus [GO:0005730]; RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; rRNA base methylation [GO:0070475]	
Q3KNW1	reviewed	SNAI3_HUMAN	Zinc finger protein SNAI3 (Protein snail homolog 3) (Zinc finger protein 293)	SNAI3 ZNF293	Homo sapiens (Human)	292	FUNCTION: Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity). {ECO:0000250}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	copper ion binding [GO:0005507]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; copper ion binding [GO:0005507]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q3KP31	reviewed	ZN791_HUMAN	Zinc finger protein 791	ZNF791	Homo sapiens (Human)	576	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q3KQV9	reviewed	UAP1L_HUMAN	UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 (EC 2.7.7.-)	UAP1L1	Homo sapiens (Human)	507			UDP-N-acetylglucosamine biosynthetic process [GO:0006048]		UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977]	UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	
Q3KQZ1	reviewed	S2535_HUMAN	Solute carrier family 25 member 35	SLC25A35	Homo sapiens (Human)	300	FUNCTION: Putative antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria. {ECO:0000269|PubMed:18682385}.			mitochondrial inner membrane [GO:0005743]		mitochondrial inner membrane [GO:0005743]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q3LI61	reviewed	KR202_HUMAN	Keratin-associated protein 20-2	KRTAP20-2 KAP20.2	Homo sapiens (Human)	65	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3LI67	reviewed	KRA63_HUMAN	Keratin-associated protein 6-3	KRTAP6-3 KAP6.3	Homo sapiens (Human)	103	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.		keratinization [GO:0031424]	cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]; keratinization [GO:0031424]	
Q3LI73	reviewed	KR194_HUMAN	Keratin-associated protein 19-4	KRTAP19-4 KAP19.4	Homo sapiens (Human)	84	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3LI81	reviewed	KR271_HUMAN	Keratin-associated protein 27-1	KRTAP27-1 KAP27.1	Homo sapiens (Human)	207	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; keratin filament [GO:0045095]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; keratin filament [GO:0045095]; structural molecule activity [GO:0005198]	
Q3LI83	reviewed	KR241_HUMAN	Keratin-associated protein 24-1	KRTAP24-1 KAP24.1	Homo sapiens (Human)	254	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	MISCELLANEOUS: Has a low cysteine content when compared to the majority of known KAP family members. Possesses several C-terminal tyrosine-containing tandem decameric repeat structures.		cytosol [GO:0005829]; keratin filament [GO:0045095]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; keratin filament [GO:0045095]; structural molecule activity [GO:0005198]	
Q3MIS6	reviewed	ZN528_HUMAN	Zinc finger protein 528	ZNF528 KIAA1827	Homo sapiens (Human)	628	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q3MIX3	reviewed	ADCK5_HUMAN	Uncharacterized aarF domain-containing protein kinase 5 (EC 2.7.11.-)	ADCK5	Homo sapiens (Human)	580	FUNCTION: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).		phosphorylation [GO:0016310]	membrane [GO:0016020]	protein serine/threonine kinase activity [GO:0004674]	membrane [GO:0016020]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q3SXZ3	reviewed	ZN718_HUMAN	Zinc finger protein 718	ZNF718	Homo sapiens (Human)	478	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q3ZCQ2	reviewed	AX2R_HUMAN	Annexin-2 receptor (Annexin II receptor) (AXIIR)	ANXA2R AX2R C5orf39	Homo sapiens (Human)	193	FUNCTION: May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.				signaling receptor activity [GO:0038023]	signaling receptor activity [GO:0038023]	
Q3ZCW2	reviewed	LEGL_HUMAN	Galectin-related protein (Galectin-like protein) (Lectin galactoside-binding-like protein)	LGALSL GRP HSPC159	Homo sapiens (Human)	172	FUNCTION: Does not bind lactose, and may not bind carbohydrates. {ECO:0000269|PubMed:18320588, ECO:0000269|PubMed:18433051}.				carbohydrate binding [GO:0030246]	carbohydrate binding [GO:0030246]	
Q400G9	reviewed	AMZ1_HUMAN	Archaemetzincin-1 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 1)	AMZ1 KIAA1950	Homo sapiens (Human)	498	FUNCTION: Probable zinc metalloprotease. {ECO:0000250|UniProtKB:Q8TXW1}.		proteolysis [GO:0006508]		metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]	metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; proteolysis [GO:0006508]	
Q494W8	reviewed	CRFM7_HUMAN	CHRNA7-FAM7A fusion protein (CHRNA7-DR1) (D-10)	CHRFAM7A	Homo sapiens (Human)	412			synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; postsynapse [GO:0098794]; synapse [GO:0045202]	acetylcholine binding [GO:0042166]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; postsynapse [GO:0098794]; synapse [GO:0045202]; acetylcholine binding [GO:0042166]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888]; synaptic transmission, cholinergic [GO:0007271]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q494X3	reviewed	ZN404_HUMAN	Zinc finger protein 404	ZNF404	Homo sapiens (Human)	552	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q495B1	reviewed	AKD1A_HUMAN	Ankyrin repeat and death domain-containing protein 1A	ANKDD1A	Homo sapiens (Human)	522		MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	signal transduction [GO:0007165]			signal transduction [GO:0007165]	
Q496H8	reviewed	NRN1L_HUMAN	Neuritin-like protein	NRN1L UNQ2446/PRO5725	Homo sapiens (Human)	165			neuron projection extension [GO:1990138]	axon [GO:0030424]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	identical protein binding [GO:0042802]	axon [GO:0030424]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; identical protein binding [GO:0042802]; neuron projection extension [GO:1990138]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Q499Z3	reviewed	SLNL1_HUMAN	Schlafen-like protein 1	SLFNL1	Homo sapiens (Human)	407					ATP binding [GO:0005524]	ATP binding [GO:0005524]	
Q499Z4	reviewed	ZN672_HUMAN	Zinc finger protein 672	ZNF672	Homo sapiens (Human)	452	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q49A92	reviewed	CH034_HUMAN	Uncharacterized protein C8orf34 (Protein VEST-1)	C8orf34	Homo sapiens (Human)	538							
Q49AA0	reviewed	ZFP69_HUMAN	Zinc finger protein 69 homolog (Zinc finger protein 642)	ZFP69 ZNF642	Homo sapiens (Human)	526	FUNCTION: Putative transcription factor that appears to regulate lipid metabolism. {ECO:0000250|UniProtKB:A2A761}.		lipid metabolic process [GO:0006629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of lipid metabolic process [GO:0019216]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; lipid metabolic process [GO:0006629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of lipid metabolic process [GO:0019216]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A2A761}.
Q49AG3	reviewed	ZBED5_HUMAN	Zinc finger BED domain-containing protein 5 (Transposon-derived Buster1 transposase-like protein)	ZBED5 Buster1	Homo sapiens (Human)	693		MISCELLANEOUS: May be derived from an ancient transposon that has lost its ability to translocate.			DNA binding [GO:0003677]; metal ion binding [GO:0046872]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	
Q49AR2	reviewed	CE022_HUMAN	UPF0489 protein C5orf22	C5orf22	Homo sapiens (Human)	442							
Q4AE62	reviewed	GTDC1_HUMAN	Glycosyltransferase-like domain-containing protein 1 (Mannosyltransferase-like protein Xa) (Mat-Xa)	GTDC1	Homo sapiens (Human)	458					glycosyltransferase activity [GO:0016757]	glycosyltransferase activity [GO:0016757]	
Q4G0F5	reviewed	VP26B_HUMAN	Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B)	VPS26B	Homo sapiens (Human)	336	FUNCTION: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity). {ECO:0000250|UniProtKB:O75436, ECO:0000250|UniProtKB:Q8C0E2}.		cellular response to type II interferon [GO:0071346]; intracellular protein transport [GO:0006886]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome [GO:0005770]; phagocytic vesicle [GO:0045335]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]		cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome [GO:0005770]; phagocytic vesicle [GO:0045335]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; cellular response to type II interferon [GO:0071346]; intracellular protein transport [GO:0006886]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8C0E2}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8C0E2}. Early endosome {ECO:0000250|UniProtKB:Q8C0E2}. Late endosome {ECO:0000250|UniProtKB:Q8C0E2}. Note=Localizes to early and late endosomal structures (By similarity). {ECO:0000250|UniProtKB:Q8C0E2}.
Q4G0I0	reviewed	UQCC4_HUMAN	Ubiquinol-cytochrome c reductase complex assembly factor 4 (Protein CCSMST1)	UQCC4 C16orf91 CCSMST1	Homo sapiens (Human)	132	FUNCTION: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation. {ECO:0000250|UniProtKB:Q6RUT7}.		mitochondrial respiratory chain complex III assembly [GO:0034551]	mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469]		mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469]; mitochondrial respiratory chain complex III assembly [GO:0034551]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q6RUT7}; Single-pass membrane protein {ECO:0000305}.
Q4G0S7	reviewed	CC152_HUMAN	Coiled-coil domain-containing protein 152	CCDC152 Chr5_400	Homo sapiens (Human)	254							
Q4G0Z9	reviewed	MCMD2_HUMAN	Minichromosome maintenance domain-containing protein 2 (MCM domain-containing protein 2)	MCMDC2 C8orf45	Homo sapiens (Human)	681	FUNCTION: Plays an important role in meiotic recombination and associated DNA double-strand break repair. {ECO:0000250|UniProtKB:E9Q956}.		DNA duplex unwinding [GO:0032508]; double-strand break repair via break-induced replication [GO:0000727]; meiotic cell cycle [GO:0051321]		ATP binding [GO:0005524]; DNA binding [GO:0003677]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA duplex unwinding [GO:0032508]; double-strand break repair via break-induced replication [GO:0000727]; meiotic cell cycle [GO:0051321]	
Q4G112	reviewed	HSF5_HUMAN	Heat shock factor protein 5 (HSF 5) (Heat shock transcription factor 5) (HSTF 5)	HSF5 HSTF5	Homo sapiens (Human)	596	FUNCTION: May act as a transcriptional factor. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q4KMZ1	reviewed	IQCC_HUMAN	IQ domain-containing protein C	IQCC	Homo sapiens (Human)	466							
Q4KMZ8	reviewed	NKAI1_HUMAN	Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1) (Protein FAM77C)	NKAIN1 FAM77C	Homo sapiens (Human)	207			regulation of sodium ion transport [GO:0002028]	plasma membrane [GO:0005886]	ATPase binding [GO:0051117]	plasma membrane [GO:0005886]; ATPase binding [GO:0051117]; regulation of sodium ion transport [GO:0002028]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q4V339	reviewed	ZNG1F_HUMAN	Zinc-regulated GTPase metalloprotein activator 1F (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 6) (COBW domain-containing protein 6)	ZNG1F CBWD6 CBWD7	Homo sapiens (Human)	395	FUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (By similarity). Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584702). Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1 (By similarity). After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1F to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis (By similarity). GTP/GDP exchange is required for release of active METAP1 (By similarity). {ECO:0000250|UniProtKB:Q8VEH6, ECO:0000269|PubMed:35584702}.			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VEH6}.
Q4VC39	reviewed	HIG2B_HUMAN	Putative HIG1 domain family member 2B (HIG1 domain family member 2B pseudogene)	HIGD2B HIGD2BP	Homo sapiens (Human)	106			mitochondrial respirasome assembly [GO:0097250]	membrane [GO:0016020]; mitochondrion [GO:0005739]		membrane [GO:0016020]; mitochondrion [GO:0005739]; mitochondrial respirasome assembly [GO:0097250]	SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00836}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00836}.
Q4VXA5	reviewed	KHDC1_HUMAN	KH homology domain-containing protein 1	KHDC1 C6orf147 C6orf148	Homo sapiens (Human)	237				cytoplasm [GO:0005737]; membrane [GO:0016020]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; membrane [GO:0016020]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q4VXU2	reviewed	PAP1L_HUMAN	Polyadenylate-binding protein 1-like	PABPC1L C20orf119	Homo sapiens (Human)	614				cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]	
Q4W5P6	reviewed	SIM43_HUMAN	Small integral membrane protein 43 (Nodal enhanced mesendoderm micropeptide) (NEMEP)	SMIM43 TMEM155	Homo sapiens (Human)	63	FUNCTION: Required for mesendoderm differentiation (By similarity). Interacts with glucose transporters and promotes glucose uptake (PubMed:35810171). Probably augments the glucose uptake capacity of glucose transporter proteins to meet the energy needs of mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:A0A286YD83, ECO:0000269|PubMed:35810171}.		mesendoderm development [GO:0048382]; positive regulation of glucose transmembrane transport [GO:0010828]	plasma membrane [GO:0005886]	transmembrane transporter binding [GO:0044325]	plasma membrane [GO:0005886]; transmembrane transporter binding [GO:0044325]; mesendoderm development [GO:0048382]; positive regulation of glucose transmembrane transport [GO:0010828]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A0A286YD83}; Single-pass membrane protein {ECO:0000255}.
Q502W7	reviewed	CCD38_HUMAN	Coiled-coil domain-containing protein 38	CCDC38	Homo sapiens (Human)	563			intraciliary anterograde transport [GO:0035720]; sperm flagellum assembly [GO:0120316]	centrosome [GO:0005813]; manchette [GO:0002177]; perinuclear region of cytoplasm [GO:0048471]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]		centrosome [GO:0005813]; manchette [GO:0002177]; perinuclear region of cytoplasm [GO:0048471]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; intraciliary anterograde transport [GO:0035720]; sperm flagellum assembly [GO:0120316]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25074808}.
Q504U0	reviewed	CD046_HUMAN	Renal cancer differentiation gene 1 protein	C4orf46 RCDG1	Homo sapiens (Human)	113				cytosol [GO:0005829]		cytosol [GO:0005829]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25059753}.
Q50LG9	reviewed	LRC24_HUMAN	Leucine-rich repeat-containing protein 24	LRRC24	Homo sapiens (Human)	513			positive regulation of synapse assembly [GO:0051965]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]		cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; positive regulation of synapse assembly [GO:0051965]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q52LA3	reviewed	LIN52_HUMAN	Protein lin-52 homolog	LIN52 C14orf46	Homo sapiens (Human)	116			regulation of DNA-templated transcription [GO:0006355]	DRM complex [GO:0070176]; nucleoplasm [GO:0005654]		DRM complex [GO:0070176]; nucleoplasm [GO:0005654]; regulation of DNA-templated transcription [GO:0006355]	
Q52LD8	reviewed	RFTN2_HUMAN	Raftlin-2 (Raft-linking protein 2)	RFTN2 C2orf11	Homo sapiens (Human)	501	FUNCTION: Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. {ECO:0000250|UniProtKB:Q8CHX7}.		dsRNA transport [GO:0033227]; response to exogenous dsRNA [GO:0043330]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; dsRNA transport [GO:0033227]; response to exogenous dsRNA [GO:0043330]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14699}; Lipid-anchor {ECO:0000250|UniProtKB:Q14699}.
Q52M58	reviewed	CN177_HUMAN	Testis-specific protein LINC02914 (Long intergenic non-protein coding RNA 2914)	LINC02914 C14orf177	Homo sapiens (Human)	125	FUNCTION: May play a role in the flagellum biology. {ECO:0000303|PubMed:28891297}.			cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28891297}. Nucleus {ECO:0000269|PubMed:28891297}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:28891297}. Note=Detected in the cytoplasm of germ cells in all stages of development up to the cytoplasmic lobes of elongated spermatids, whereas it appeared stronger in the nucleus of premeiotic and meiotic germ cells. Localizes in the headpiece and midpiece of ejaculated sperm. {ECO:0000269|PubMed:28891297}.
Q52M93	reviewed	Z585B_HUMAN	Zinc finger protein 585B (zinc finger protein 41-like protein)	ZNF585B	Homo sapiens (Human)	769	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q53EQ6	reviewed	TIGD5_HUMAN	Tigger transposable element-derived protein 5	TIGD5	Homo sapiens (Human)	642				nucleus [GO:0005634]	DNA binding [GO:0003677]	nucleus [GO:0005634]; DNA binding [GO:0003677]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q53EV4	reviewed	LRC23_HUMAN	Leucine-rich repeat-containing protein 23 (Leucine-rich protein B7)	LRRC23 LRPB7	Homo sapiens (Human)	343				cytoplasm [GO:0005737]; cytosol [GO:0005829]		cytoplasm [GO:0005737]; cytosol [GO:0005829]	
Q53FE4	reviewed	CD017_HUMAN	Uncharacterized protein C4orf17	C4orf17	Homo sapiens (Human)	359							
Q53RY4	reviewed	KCP3_HUMAN	Keratinocyte-associated protein 3 (KCP-3)	KRTCAP3 KCP3 UNQ3066/PRO9898	Homo sapiens (Human)	240				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q53S08	reviewed	RAB6D_HUMAN	Ras-related protein Rab-6D (Rab6-like protein WTH3DI)	RAB6D WTH3DI	Homo sapiens (Human)	254			intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	
Q53S58	reviewed	TM177_HUMAN	Transmembrane protein 177	TMEM177	Homo sapiens (Human)	311	FUNCTION: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. {ECO:0000269|PubMed:29154948}.			mitochondrial inner membrane [GO:0005743]		mitochondrial inner membrane [GO:0005743]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:29154948}; Multi-pass membrane protein {ECO:0000255}.
Q53S99	reviewed	CB083_HUMAN	Folate transporter-like protein C2orf83	C2orf83	Homo sapiens (Human)	150			organic substance transport [GO:0071702]	membrane [GO:0016020]	vitamin transmembrane transporter activity [GO:0090482]	membrane [GO:0016020]; vitamin transmembrane transporter activity [GO:0090482]; organic substance transport [GO:0071702]	
Q53SF7	reviewed	COBL1_HUMAN	Cordon-bleu protein-like 1	COBLL1 KIAA0977	Homo sapiens (Human)	1128				extracellular exosome [GO:0070062]	actin monomer binding [GO:0003785]; cadherin binding [GO:0045296]	extracellular exosome [GO:0070062]; actin monomer binding [GO:0003785]; cadherin binding [GO:0045296]	
Q56A73	reviewed	SPIN4_HUMAN	Spindlin-4	SPIN4	Homo sapiens (Human)	249	FUNCTION: Exhibits H3K4me3-binding activity. {ECO:0000269|PubMed:29061846}.		gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	methylated histone binding [GO:0035064]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; methylated histone binding [GO:0035064]; gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355]	
Q56VL3	reviewed	OCAD2_HUMAN	OCIA domain-containing protein 2 (Ovarian carcinoma immunoreactive antigen-like protein)	OCIAD2	Homo sapiens (Human)	154			endocytosis [GO:0006897]; hematopoietic stem cell homeostasis [GO:0061484]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; response to bacterium [GO:0009617]	endosome [GO:0005768]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]		endosome [GO:0005768]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; endocytosis [GO:0006897]; hematopoietic stem cell homeostasis [GO:0061484]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Endosome {ECO:0000305}.
Q58FF3	reviewed	ENPLL_HUMAN	Putative endoplasmin-like protein (Putative heat shock protein 90 kDa beta member 2)	HSP90B2P GRP94B GRP94P1 TRAP1	Homo sapiens (Human)	399	FUNCTION: Putative molecular chaperone. {ECO:0000250}.		protein folding [GO:0006457]	mitochondrial inner membrane [GO:0005743]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein kinase binding [GO:0019901]; unfolded protein binding [GO:0051082]	mitochondrial inner membrane [GO:0005743]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein kinase binding [GO:0019901]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]	
Q58FG0	reviewed	HS905_HUMAN	Putative heat shock protein HSP 90-alpha A5 (Heat shock protein 90-alpha E) (Heat shock protein 90Ae)	HSP90AA5P HSP90AE	Homo sapiens (Human)	334	FUNCTION: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.			cytoplasm [GO:0005737]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q5BJE1	reviewed	CC178_HUMAN	Coiled-coil domain-containing protein 178	CCDC178 C18orf34	Homo sapiens (Human)	867				ciliary basal body [GO:0036064]		ciliary basal body [GO:0036064]	
Q5BKX6	reviewed	S45A4_HUMAN	Solute carrier family 45 member 4	SLC45A4 KIAA1126	Homo sapiens (Human)	768	FUNCTION: Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}.		sucrose transport [GO:0015770]	membrane [GO:0016020]	sucrose:proton symporter activity [GO:0008506]	membrane [GO:0016020]; sucrose:proton symporter activity [GO:0008506]; sucrose transport [GO:0015770]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5BLP8	reviewed	NICOL_HUMAN	NELL2-interacting cell ontogeny regulator 1 (Neuropeptide-like protein C4orf48)	NICOL1 C4orf48	Homo sapiens (Human)	95	FUNCTION: Testis-derived lumicrine factor that triggers epididymal differentiation and sperm maturation. {ECO:0000250|UniProtKB:Q3UR78}.			extracellular space [GO:0005615]		extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q3UR78}.
Q5CZA5	reviewed	ZN805_HUMAN	Zinc finger protein 805	ZNF805	Homo sapiens (Human)	627	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.	MISCELLANEOUS: [Isoform 1]: Gene prediction based on similarity to orthologs.	regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5EBM4	reviewed	ZN542_HUMAN	Putative zinc finger protein 542 (Zinc finger protein 542 pseudogene)	ZNF542P ZNF542	Homo sapiens (Human)	170	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5FYA8	reviewed	ARSH_HUMAN	Arylsulfatase H (ASH) (EC 3.1.6.-)	ARSH	Homo sapiens (Human)	562				endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]	arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]	endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]; arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5GH70	reviewed	XKR9_HUMAN	XK-related protein 9 (hXKR9) [Cleaved into: XK-related protein 9, processed form]	XKR9 XRG9	Homo sapiens (Human)	373	FUNCTION: [XK-related protein 9, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:25231987). {ECO:0000269|PubMed:25231987}.		apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5GH62}; Multi-pass membrane protein {ECO:0000255}.
Q5GH73	reviewed	XKR6_HUMAN	XK-related protein 6	XKR6 C8orf21 C8orf5 C8orf7 XRG6	Homo sapiens (Human)	641			apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E9Q6C8}; Multi-pass membrane protein {ECO:0000255}.
Q5GH77	reviewed	XKR3_HUMAN	XK-related protein 3 (X Kell blood group-related 3) (XTES)	XKR3 XRG3	Homo sapiens (Human)	459				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16431037}; Multi-pass membrane protein {ECO:0000269|PubMed:16431037}.
Q5H8A3	reviewed	NMS_HUMAN	Neuromedin-S	NMS	Homo sapiens (Human)	153	FUNCTION: Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. {ECO:0000250}.		locomotor rhythm [GO:0045475]; neuropeptide signaling pathway [GO:0007218]	extracellular region [GO:0005576]	G protein-coupled receptor binding [GO:0001664]	extracellular region [GO:0005576]; G protein-coupled receptor binding [GO:0001664]; locomotor rhythm [GO:0045475]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q5H913	reviewed	AR13A_HUMAN	ADP-ribosylation factor-like protein 13A	ARL13A	Homo sapiens (Human)	290			non-motile cilium assembly [GO:1905515]; receptor localization to non-motile cilium [GO:0097500]	ciliary membrane [GO:0060170]; non-motile cilium [GO:0097730]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	ciliary membrane [GO:0060170]; non-motile cilium [GO:0097730]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; non-motile cilium assembly [GO:1905515]; receptor localization to non-motile cilium [GO:0097500]	
Q5H9K5	reviewed	ZMAT1_HUMAN	Zinc finger matrin-type protein 1	ZMAT1 KIAA1789	Homo sapiens (Human)	638				nucleus [GO:0005634]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5H9M0	reviewed	PWP3B_HUMAN	PWWP domain-containing DNA repair factor 3B (PWWP3B) (Mutated melanoma-associated antigen 1-like protein 1) (MUM1-like protein 1) (PWWP domain-containing protein MUM1L1)	PWWP3B MUM1L1	Homo sapiens (Human)	696				extracellular exosome [GO:0070062]		extracellular exosome [GO:0070062]	
Q5H9R4	reviewed	ARMX4_HUMAN	Armadillo repeat-containing X-linked protein 4	ARMCX4	Homo sapiens (Human)	2290		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q5HY98	reviewed	ZN766_HUMAN	Zinc finger protein 766	ZNF766	Homo sapiens (Human)	468	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5HYK9	reviewed	ZN667_HUMAN	Zinc finger protein 667	ZNF667	Homo sapiens (Human)	610	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5HYR2	reviewed	DMRTC_HUMAN	Doublesex- and mab-3-related transcription factor C1	DMRTC1; DMRTC1B	Homo sapiens (Human)	192				chromatin [GO:0000785]; nucleus [GO:0005634]		chromatin [GO:0000785]; nucleus [GO:0005634]	
Q5I0G3	reviewed	MDH1B_HUMAN	Putative malate dehydrogenase 1B (EC 1.1.1.-)	MDH1B	Homo sapiens (Human)	518			malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099]		L-malate dehydrogenase activity [GO:0030060]	L-malate dehydrogenase activity [GO:0030060]; malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099]	
Q5I0X7	reviewed	TTC32_HUMAN	Tetratricopeptide repeat protein 32 (TPR repeat protein 32)	TTC32	Homo sapiens (Human)	151							
Q5JNZ3	reviewed	ZN311_HUMAN	Zinc finger protein 311 (Zinc finger protein zfp-31)	ZNF311 ZFP31	Homo sapiens (Human)	666	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5JPF3	reviewed	AN36C_HUMAN	Ankyrin repeat domain-containing protein 36C (Protein immuno-reactive with anti-PTH polyclonal antibodies)	ANKRD36C	Homo sapiens (Human)	1778					ion channel inhibitor activity [GO:0008200]	ion channel inhibitor activity [GO:0008200]	
Q5JPI3	reviewed	CC038_HUMAN	Uncharacterized protein C3orf38	C3orf38	Homo sapiens (Human)	329	FUNCTION: May be involved in apoptosis regulation. {ECO:0000269|PubMed:17464193}.		apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]	nucleus [GO:0005634]		nucleus [GO:0005634]; apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]	
Q5JQF8	reviewed	PAP1M_HUMAN	Polyadenylate-binding protein 1-like 2 (RNA-binding motif protein 32) (RNA-binding protein 32)	PABPC1L2A PABPC1L2 RBM32A; PABPC1L2B PABPC1L2 RBM32B	Homo sapiens (Human)	200		MISCELLANEOUS: May be not functional as it lacks the poly(A)-binding protein C-terminal (PABC) domain implicated in the mRNA stability and translation regulation.		cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]	
Q5JQS5	reviewed	OR2BB_HUMAN	Olfactory receptor 2B11	OR2B11	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q5JQS6	reviewed	GSAML_HUMAN	Germinal center-associated signaling and motility-like protein	GCSAML C1orf150	Homo sapiens (Human)	135			regulation of B cell receptor signaling pathway [GO:0050855]; regulation of lymphocyte migration [GO:2000401]			regulation of B cell receptor signaling pathway [GO:0050855]; regulation of lymphocyte migration [GO:2000401]	
Q5JRC9	reviewed	FA47A_HUMAN	Protein FAM47A	FAM47A	Homo sapiens (Human)	791							
Q5JRS4	reviewed	O10J3_HUMAN	Olfactory receptor 10J3	OR10J3 OR10J3P	Homo sapiens (Human)	329	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q5JRV8	reviewed	T255A_HUMAN	Transmembrane protein 255A (Protein FAM70A)	TMEM255A FAM70A	Homo sapiens (Human)	349			response to bacterium [GO:0009617]	membrane [GO:0016020]		membrane [GO:0016020]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5JS37	reviewed	NHLC3_HUMAN	NHL repeat-containing protein 3	NHLRC3	Homo sapiens (Human)	347			negative regulation of translation [GO:0017148]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]	translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]	azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; negative regulation of translation [GO:0017148]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5JS54	reviewed	PSMG4_HUMAN	Proteasome assembly chaperone 4 (PAC-4) (hPAC4)	PSMG4 C6orf86 PAC4	Homo sapiens (Human)	123	FUNCTION: Chaperone protein which promotes assembly of the 20S proteasome. {ECO:0000250|UniProtKB:P0C7N9}.		proteasome assembly [GO:0043248]	protein-containing complex [GO:0032991]	protein-containing complex binding [GO:0044877]	protein-containing complex [GO:0032991]; protein-containing complex binding [GO:0044877]; proteasome assembly [GO:0043248]	
Q5JSS6	reviewed	MEIG1_HUMAN	Meiosis expressed gene 1 protein homolog	MEIG1	Homo sapiens (Human)	88	FUNCTION: Essential for spermiogenesis. {ECO:0000250|UniProtKB:Q61845}.		manchette assembly [GO:1905198]; protein localization [GO:0008104]; sperm axoneme assembly [GO:0007288]	cytosol [GO:0005829]; manchette [GO:0002177]; nucleus [GO:0005634]		cytosol [GO:0005829]; manchette [GO:0002177]; nucleus [GO:0005634]; manchette assembly [GO:1905198]; protein localization [GO:0008104]; sperm axoneme assembly [GO:0007288]	
Q5JTD7	reviewed	LRC73_HUMAN	Leucine-rich repeat-containing protein 73	LRRC73 C6orf154	Homo sapiens (Human)	316							
Q5JU00	reviewed	DRC5_HUMAN	Dynein regulatory complex subunit 5 (T-complex-associated testis-expressed protein 1) (Tcte-1)	TCTE1 DRC5	Homo sapiens (Human)	501	FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility. {ECO:0000250|UniProtKB:A6H639, ECO:0000250|UniProtKB:A8HMZ4}.		flagellated sperm motility [GO:0030317]; microtubule-based movement [GO:0007018]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126]; flagellated sperm motility [GO:0030317]; microtubule-based movement [GO:0007018]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A6H639}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8HMZ4}. Note=Detected along the length of the sperm flagellum. {ECO:0000250|UniProtKB:A6H639}.
Q5JUK9	reviewed	PAGE3_HUMAN	P antigen family member 3 (PAGE-3) (G antigen family D member 1) (Prostate-associated gene 3 protein)	PAGE3 GAGED1	Homo sapiens (Human)	113							
Q5JVG2	reviewed	ZN484_HUMAN	Zinc finger protein 484	ZNF484	Homo sapiens (Human)	852	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5JVG8	reviewed	ZN506_HUMAN	Zinc finger protein 506	ZNF506	Homo sapiens (Human)	444	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleolus [GO:0005730]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleolus [GO:0005730]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5JW98	reviewed	CAHM4_HUMAN	Calcium homeostasis modulator protein 4 (Protein FAM26D)	CALHM4 C6orf78 FAM26D UNQ6481/PRO21277	Homo sapiens (Human)	314	FUNCTION: Pore-forming subunit of a voltage-gated ion channel. {ECO:0000250|UniProtKB:Q8IU99}.			membrane [GO:0016020]	monoatomic cation channel activity [GO:0005261]	membrane [GO:0016020]; monoatomic cation channel activity [GO:0005261]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5JWR5	reviewed	DOP1_HUMAN	Protein dopey-1	DOP1A DOPEY1 KIAA1117	Homo sapiens (Human)	2465	FUNCTION: May be involved in protein traffic between late Golgi and early endosomes. {ECO:0000250|UniProtKB:Q03921}.		Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031]	cytosol [GO:0005829]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; trans-Golgi network [GO:0005802]		cytosol [GO:0005829]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; trans-Golgi network [GO:0005802]; Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q03921}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q03921}.
Q5JX69	reviewed	F209B_HUMAN	Protein FAM209B	FAM209B C20orf107	Homo sapiens (Human)	171	FUNCTION: May play a role in sperm acrosome biogenesis. {ECO:0000250|UniProtKB:A2APA5}.	MISCELLANEOUS: The primate lineage appears to have undergone gene duplication of FAM209, such that humans contain FAM209A and FAM209B. {ECO:0000305}.	cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	nuclear inner membrane [GO:0005637]; nucleus [GO:0005634]		nuclear inner membrane [GO:0005637]; nucleus [GO:0005634]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:A2APA5}; Single-pass type I membrane protein {ECO:0000255}.
Q5JXM2	reviewed	MET24_HUMAN	Probable methyltransferase-like protein 24 (EC 2.1.1.-)	METTL24 C6orf186	Homo sapiens (Human)	366	FUNCTION: Probable methyltransferase. {ECO:0000305}.		methylation [GO:0032259]	extracellular region [GO:0005576]	methyltransferase activity [GO:0008168]	extracellular region [GO:0005576]; methyltransferase activity [GO:0008168]; methylation [GO:0032259]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5M9N0	reviewed	CD158_HUMAN	Coiled-coil domain-containing protein 158	CCDC158	Homo sapiens (Human)	1113							
Q5MCW4	reviewed	ZN569_HUMAN	Zinc finger protein 569	ZNF569	Homo sapiens (Human)	686	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q5PT55	reviewed	NTCP5_HUMAN	Sodium/bile acid cotransporter 5 (Na(+)/bile acid cotransporter 5) (Solute carrier family 10 member 5)	SLC10A5	Homo sapiens (Human)	438			bile acid and bile salt transport [GO:0015721]	membrane [GO:0016020]	bile acid:sodium symporter activity [GO:0008508]	membrane [GO:0016020]; bile acid:sodium symporter activity [GO:0008508]; bile acid and bile salt transport [GO:0015721]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5R3K3	reviewed	CAHM6_HUMAN	Calcium homeostasis modulator protein 6 (Protein FAM26F)	CALHM6 C6orf187 FAM26F	Homo sapiens (Human)	315	FUNCTION: Pore-forming subunit of a voltage-gated ion channel. {ECO:0000250|UniProtKB:Q8IU99}.			membrane [GO:0016020]	monoatomic cation channel activity [GO:0005261]	membrane [GO:0016020]; monoatomic cation channel activity [GO:0005261]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5SNV9	reviewed	CA167_HUMAN	Uncharacterized protein C1orf167	C1orf167	Homo sapiens (Human)	1468							
Q5SRH9	reviewed	TT39A_HUMAN	Tetratricopeptide repeat protein 39A (TPR repeat protein 39A) (Differentially expressed in MCF-7 with estradiol protein 6) (DEME-6)	TTC39A C1orf34 KIAA0452	Homo sapiens (Human)	613				centrosome [GO:0005813]		centrosome [GO:0005813]	
Q5SSQ6	reviewed	SAPC1_HUMAN	Suppressor APC domain-containing protein 1 (Protein G7d)	SAPCD1 C6orf26 G7D NG23	Homo sapiens (Human)	148							
Q5SV17	reviewed	TM240_HUMAN	Transmembrane protein 240	TMEM240 C1orf70	Homo sapiens (Human)	173				synaptic membrane [GO:0097060]; TMEM240-body [GO:0160045]		synaptic membrane [GO:0097060]; TMEM240-body [GO:0160045]	SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:B2RWJ3}. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5SV97	reviewed	PERM1_HUMAN	PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1)	PERM1 C1orf170	Homo sapiens (Human)	790	FUNCTION: Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. {ECO:0000250|UniProtKB:Q149B8}.		regulation of DNA-templated transcription [GO:0006355]; response to muscle activity [GO:0014850]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; regulation of DNA-templated transcription [GO:0006355]; response to muscle activity [GO:0014850]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q149B8}. Nucleus {ECO:0000250|UniProtKB:Q149B8}. Note=Shows a nuclear localization in the presence of PPARGC1A. {ECO:0000250|UniProtKB:Q149B8}.
Q5SVQ8	reviewed	ZBT41_HUMAN	Zinc finger and BTB domain-containing protein 41	ZBTB41 FRBZ1	Homo sapiens (Human)	909	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5SWX8	reviewed	ODR4_HUMAN	Protein odr-4 homolog (hODR-4) (LAG1-interacting protein) (Transactivated by transforming growth factor beta protein 1)	ODR4 C1orf27 TTG1 TTG1A	Homo sapiens (Human)	454	FUNCTION: May play a role in the trafficking of a subset of G-protein coupled receptors. {ECO:0000250|UniProtKB:Q8I7F8}.		protein localization [GO:0008104]	membrane [GO:0016020]		membrane [GO:0016020]; protein localization [GO:0008104]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q5SXM1	reviewed	ZN678_HUMAN	Zinc finger protein 678	ZNF678	Homo sapiens (Human)	525	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5SY68	reviewed	S1A7B_HUMAN	Protein S100-A7-like 2 (S100 calcium-binding protein A7-like 2)	S100A7L2 S100A7B	Homo sapiens (Human)	101				cytoplasm [GO:0005737]; extracellular space [GO:0005615]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]	
Q5SYE7	reviewed	NHSL1_HUMAN	NHS-like protein 1	NHSL1 C6orf63 KIAA1357	Homo sapiens (Human)	1610			cell differentiation [GO:0030154]			cell differentiation [GO:0030154]	
Q5SZD1	reviewed	CF141_HUMAN	Uncharacterized protein C6orf141	C6orf141	Homo sapiens (Human)	244							
Q5SZD4	reviewed	GLYL3_HUMAN	Glycine N-acyltransferase-like protein 3 (EC 2.3.1.13) (Acyl-CoA:glycine-N-acyltransferase-like protein 3)	GLYATL3 C6orf140	Homo sapiens (Human)	288	FUNCTION: Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway. {ECO:0000250|UniProtKB:E9Q5L8}.		lipid metabolic process [GO:0006629]	mitochondrion [GO:0005739]	glycine N-acyltransferase activity [GO:0047961]	mitochondrion [GO:0005739]; glycine N-acyltransferase activity [GO:0047961]; lipid metabolic process [GO:0006629]	
Q5SZI1	reviewed	LRAD2_HUMAN	Low-density lipoprotein receptor class A domain-containing protein 2	LDLRAD2	Homo sapiens (Human)	272				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q5T0B9	reviewed	ZN362_HUMAN	Zinc finger protein 362	ZNF362 PP6997	Homo sapiens (Human)	420	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5T1A1	reviewed	DCST2_HUMAN	DC-STAMP domain-containing protein 2	DCST2	Homo sapiens (Human)	773	FUNCTION: Essential sperm cell-surface protein required for sperm-egg fusion and fertilization. {ECO:0000250|UniProtKB:A0A140LIJ0}.		fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; sperm-egg recognition [GO:0035036]	acrosomal membrane [GO:0002080]		acrosomal membrane [GO:0002080]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; sperm-egg recognition [GO:0035036]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:A0A140LIJ0}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in the anterior acrosome before the acrosome reaction and then translocates to the equatorial segment in acrosome-reacted sperm. {ECO:0000250|UniProtKB:A0A140LIJ0}.
Q5T1J5	reviewed	CHCH9_HUMAN	Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing 2 pseudogene 9)	CHCHD2P9 C9orf49 CHCHD9	Homo sapiens (Human)	151			mitochondrion organization [GO:0007005]; positive regulation of transcription by RNA polymerase II [GO:0045944]	mitochondrion [GO:0005739]; nucleus [GO:0005634]	sequence-specific DNA binding [GO:0043565]	mitochondrion [GO:0005739]; nucleus [GO:0005634]; sequence-specific DNA binding [GO:0043565]; mitochondrion organization [GO:0007005]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q5T1N1	reviewed	AKND1_HUMAN	Protein AKNAD1	AKNAD1 C1orf62	Homo sapiens (Human)	836							
Q5T1S8	reviewed	NCMAP_HUMAN	Noncompact myelin-associated protein (Myelin protein of 11 kDa) (MP11)	NCMAP C1orf130	Homo sapiens (Human)	102	FUNCTION: Plays a role in myelin formation. {ECO:0000250}.		peripheral nervous system myelin formation [GO:0032290]; positive regulation of myelination [GO:0031643]	paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220]	structural constituent of myelin sheath [GO:0019911]	paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220]; structural constituent of myelin sheath [GO:0019911]; peripheral nervous system myelin formation [GO:0032290]; positive regulation of myelination [GO:0031643]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized mainly in the Schmidt-Lanterman incisures and paranodes of noncompact peripheral nerve myelin. {ECO:0000250}.
Q5T292	reviewed	TM273_HUMAN	Transmembrane protein 273	TMEM273 C10orf128	Homo sapiens (Human)	105				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q5T2L2	reviewed	AKCL1_HUMAN	Putative aldo-keto reductase family 1 member C8 (Aldo-keto reductase family 1 member C-like protein 1) (EC 1.1.1.-)	AKR1C8 AKR1C8P AKR1CL1	Homo sapiens (Human)	129				cytoplasm [GO:0005737]	oxidoreductase activity [GO:0016491]	cytoplasm [GO:0005737]; oxidoreductase activity [GO:0016491]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q5T3I0	reviewed	GPTC4_HUMAN	G patch domain-containing protein 4	GPATCH4 GPATC4	Homo sapiens (Human)	446				nucleolus [GO:0005730]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; RNA binding [GO:0003723]	
Q5T5D7	reviewed	ZN684_HUMAN	Zinc finger protein 684	ZNF684	Homo sapiens (Human)	378	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5T5J6	reviewed	SWT1_HUMAN	Transcriptional protein SWT1	SWT1 C1orf26	Homo sapiens (Human)	900				nucleus [GO:0005634]		nucleus [GO:0005634]	
Q5T5M9	reviewed	CCNJ_HUMAN	Cyclin-J	CCNJ	Homo sapiens (Human)	372			mitotic cell cycle phase transition [GO:0044772]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; mitotic cell cycle phase transition [GO:0044772]	
Q5T5S1	reviewed	CC183_HUMAN	Coiled-coil domain-containing protein 183	CCDC183 KIAA1984	Homo sapiens (Human)	534							
Q5T681	reviewed	CJ062_HUMAN	Uncharacterized protein C10orf62	C10orf62	Homo sapiens (Human)	223							
Q5T6J7	reviewed	GNTK_HUMAN	Probable gluconokinase (EC 2.7.1.12) (Gluconate kinase)	IDNK C9orf103	Homo sapiens (Human)	187			D-gluconate catabolic process [GO:0046177]; phosphorylation [GO:0016310]		ATP binding [GO:0005524]; gluconokinase activity [GO:0046316]	ATP binding [GO:0005524]; gluconokinase activity [GO:0046316]; D-gluconate catabolic process [GO:0046177]; phosphorylation [GO:0016310]	
Q5T7M9	reviewed	DIK1A_HUMAN	Divergent protein kinase domain 1A (Protein FAM69A)	DIPK1A FAM69A	Homo sapiens (Human)	428				endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D6I7}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9D6I7}.
Q5T9S5	reviewed	CCD18_HUMAN	Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24)	CCDC18	Homo sapiens (Human)	1454				centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]		centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26638075}.
Q5TAG4	reviewed	NBPFC_HUMAN	Neuroblastoma breakpoint family member 12 (Chromosome 1 amplified sequence 1)	NBPF12 COAS1 KIAA1245	Homo sapiens (Human)	1457		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q5TC12	reviewed	ATPF1_HUMAN	ATP synthase mitochondrial F1 complex assembly factor 1 (ATP11 homolog)	ATPAF1 ATP11	Homo sapiens (Human)	328	FUNCTION: May play an essential role for the assembly of the mitochondrial F1-F0 complex. {ECO:0000250}.		mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
Q5TC63	reviewed	GRTP1_HUMAN	Growth hormone-regulated TBC protein 1 (TBC1 domain family member 6)	GRTP1 TBC1D6	Homo sapiens (Human)	336	FUNCTION: May act as a GTPase-activating protein for Rab family protein(s).				GTPase activator activity [GO:0005096]	GTPase activator activity [GO:0005096]	
Q5TEA3	reviewed	DAAF9_HUMAN	Dynein axonemal assembly factor 9 (DNAAF9)	DNAAF9 C20orf194	Homo sapiens (Human)	1177	FUNCTION: May act as an effector for ARL3.						
Q5TEA6	reviewed	SE1L2_HUMAN	Protein sel-1 homolog 2 (Suppressor of lin-12-like protein 2) (Sel-1L2)	SEL1L2 C20orf50	Homo sapiens (Human)	688			ERAD pathway [GO:0036503]	endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]; ERAD pathway [GO:0036503]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q5TEC3	reviewed	ZN697_HUMAN	Zinc finger protein 697	ZNF697	Homo sapiens (Human)	545	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5TF21	reviewed	SOGA3_HUMAN	Protein SOGA3	SOGA3 C6orf174	Homo sapiens (Human)	947			regulation of autophagy [GO:0010506]	extracellular space [GO:0005615]; membrane [GO:0016020]		extracellular space [GO:0005615]; membrane [GO:0016020]; regulation of autophagy [GO:0010506]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5TF39	reviewed	MFS4B_HUMAN	Sodium-dependent glucose transporter 1 (Major facilitator superfamily domain-containing protein 4B)	MFSD4B KIAA1919 NAGLT1 HSPC100	Homo sapiens (Human)	518	FUNCTION: May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney. {ECO:0000250|UniProtKB:Q80T22}.		sodium ion transport [GO:0006814]	apical plasma membrane [GO:0016324]	glucose transmembrane transporter activity [GO:0005355]; symporter activity [GO:0015293]	apical plasma membrane [GO:0016324]; glucose transmembrane transporter activity [GO:0005355]; symporter activity [GO:0015293]; sodium ion transport [GO:0006814]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q80T22}; Multi-pass membrane protein {ECO:0000250}.
Q5TFE4	reviewed	NT5D1_HUMAN	5'-nucleotidase domain-containing protein 1 (EC 3.1.3.-)	NT5DC1 NT5C2L1 LP2642	Homo sapiens (Human)	455					5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]	5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]	
Q5TFG8	reviewed	ZC21B_HUMAN	Zinc finger C2HC domain-containing protein 1B	ZC2HC1B C6orf94 FAM164B	Homo sapiens (Human)	222					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q5TG30	reviewed	RHG40_HUMAN	Rho GTPase-activating protein 40 (Rho-type GTPase-activating protein 40)	ARHGAP40 C20orf95	Homo sapiens (Human)	622	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.		regulation of actin filament polymerization [GO:0030833]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; regulation of actin filament polymerization [GO:0030833]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	
Q5TGI0	reviewed	FAXC_HUMAN	Failed axon connections homolog	FAXC C6orf168	Homo sapiens (Human)	409	FUNCTION: May play a role in axonal development. {ECO:0000250}.			cytoplasm [GO:0005737]; membrane [GO:0016020]		cytoplasm [GO:0005737]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5TGS1	reviewed	HES3_HUMAN	Transcription factor HES-3 (Class B basic helix-loop-helix protein 43) (bHLHb43) (Hairy and enhancer of split 3)	HES3 BHLHB43	Homo sapiens (Human)	186	FUNCTION: Transcriptional repressor of genes that require a bHLH protein for their transcription. {ECO:0000250}.		anterior/posterior pattern specification [GO:0009952]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anterior/posterior pattern specification [GO:0009952]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q5TGY1	reviewed	TMCO4_HUMAN	Transmembrane and coiled-coil domain-containing protein 4	TMCO4	Homo sapiens (Human)	634				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5THK1	reviewed	PR14L_HUMAN	Protein PRR14L (Proline rich 14-like protein)	PRR14L C22orf30	Homo sapiens (Human)	2151							
Q5TIE3	reviewed	VW5B1_HUMAN	von Willebrand factor A domain-containing protein 5B1	VWA5B1	Homo sapiens (Human)	1220				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5TZ20	reviewed	OR2G6_HUMAN	Olfactory receptor 2G6	OR2G6	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q5TZJ5	reviewed	S31A1_HUMAN	Spermatogenesis-associated protein 31A1 (Protein FAM75A1)	SPATA31A1 C9orf36 FAM75A1 FAM75A2 SPATA31A2	Homo sapiens (Human)	1347	FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5U3C3	reviewed	TM164_HUMAN	Transmembrane protein 164	TMEM164	Homo sapiens (Human)	297	FUNCTION: Positive regulator of ferroptosis. Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death. {ECO:0000269|PubMed:35947500}.		positive regulation of ferroptosis [GO:0160020]	membrane [GO:0016020]		membrane [GO:0016020]; positive regulation of ferroptosis [GO:0160020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5UAW9	reviewed	GP157_HUMAN	G-protein coupled receptor 157	GPR157	Homo sapiens (Human)	335	FUNCTION: Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger. {ECO:0000250|UniProtKB:Q8C206}.		adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; radial glial cell differentiation [GO:0060019]	ciliary membrane [GO:0060170]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	ciliary membrane [GO:0060170]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; radial glial cell differentiation [GO:0060019]	SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q8C206}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed in the primary cilia of radial glial progenitors (RGPs) exposed to the cerebrospinal fluid. {ECO:0000250|UniProtKB:Q8C206}.
Q5VIY5	reviewed	ZN468_HUMAN	Zinc finger protein 468	ZNF468	Homo sapiens (Human)	522	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5VSG8	reviewed	MANEL_HUMAN	Glycoprotein endo-alpha-1,2-mannosidase-like protein (EC 3.2.1.-)	MANEAL	Homo sapiens (Human)	457				Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	alpha-mannosidase activity [GO:0004559]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; alpha-mannosidase activity [GO:0004559]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q5VT79	reviewed	AXA81_HUMAN	Annexin A8-like protein 1	ANXA8L1 ANXA8L2	Homo sapiens (Human)	327			endosomal transport [GO:0016197]; endosome organization [GO:0007032]	cytoplasm [GO:0005737]; sarcolemma [GO:0042383]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]	cytoplasm [GO:0005737]; sarcolemma [GO:0042383]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]	
Q5VTE6	reviewed	ANGE2_HUMAN	Protein angel homolog 2	ANGEL2 KIAA0759L	Homo sapiens (Human)	544			3'-UTR-mediated mRNA stabilization [GO:0070935]; negative regulation of mitotic cell cycle [GO:0045930]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]	3'-5'-RNA exonuclease activity [GO:0000175]; mRNA 3'-UTR binding [GO:0003730]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; 3'-5'-RNA exonuclease activity [GO:0000175]; mRNA 3'-UTR binding [GO:0003730]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; negative regulation of mitotic cell cycle [GO:0045930]	
Q5VTJ3	reviewed	KLD7A_HUMAN	Kelch domain-containing protein 7A	KLHDC7A	Homo sapiens (Human)	777				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5VTL8	reviewed	PR38B_HUMAN	Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27)	PRPF38B	Homo sapiens (Human)	546	FUNCTION: May be required for pre-mRNA splicing. {ECO:0000305}.		mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	precatalytic spliceosome [GO:0071011]	RNA binding [GO:0003723]	precatalytic spliceosome [GO:0071011]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5VTM2	reviewed	AGAP9_HUMAN	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9 (AGAP-9) (Centaurin-gamma-like family member 6)	AGAP9 CTGLF6	Homo sapiens (Human)	703	FUNCTION: Putative GTPase-activating protein. {ECO:0000305}.	MISCELLANEOUS: Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.			GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	
Q5VTU8	reviewed	AT5EL_HUMAN	ATP synthase subunit epsilon-like protein, mitochondrial (ATP synthase F1 subunit epsilon pseudogene 2)	ATP5F1EP2 ATP5EP2	Homo sapiens (Human)	51	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity). {ECO:0000250|UniProtKB:P56381}.		proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) [GO:0000275]; mitochondrion [GO:0005739]	hydrolase activity [GO:0016787]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) [GO:0000275]; mitochondrion [GO:0005739]; hydrolase activity [GO:0016787]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P56381}.
Q5VU65	reviewed	P210L_HUMAN	Nuclear pore membrane glycoprotein 210-like (Nucleoporin 210 kDa-like) (Nucleoporin Nup210-like)	NUP210L	Homo sapiens (Human)	1888				membrane [GO:0016020]; nuclear pore [GO:0005643]		membrane [GO:0016020]; nuclear pore [GO:0005643]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5VU69	reviewed	CP141_HUMAN	Cilia- and flagella-associated protein 141	CFAP141 C1orf189	Homo sapiens (Human)	101	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.			axonemal microtubule [GO:0005879]		axonemal microtubule [GO:0005879]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q5VUD6	reviewed	DIK1B_HUMAN	Divergent protein kinase domain 1B (Protein FAM69B)	DIPK1B C9orf136 FAM69B PP6977	Homo sapiens (Human)	431				endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q5VUJ5	reviewed	AGAP7_HUMAN	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7 (AGAP-7) (Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7 pseudogene) (Centaurin-gamma-like family member 4)	AGAP7P AGAP7 CTGLF4	Homo sapiens (Human)	663	FUNCTION: Putative GTPase-activating protein. {ECO:0000305}.	MISCELLANEOUS: Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.			GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	
Q5VUJ6	reviewed	LRCH2_HUMAN	Leucine-rich repeat and calponin homology domain-containing protein 2	LRCH2 KIAA1495	Homo sapiens (Human)	765	FUNCTION: May play a role in the organization of the cytoskeleton. {ECO:0000250|UniProtKB:Q960C5, ECO:0000250|UniProtKB:Q96II8}.						
Q5VUY0	reviewed	ADCL3_HUMAN	Arylacetamide deacetylase-like 3 (EC 3.1.1.-)	AADACL3	Homo sapiens (Human)	407				membrane [GO:0016020]	carboxylic ester hydrolase activity [GO:0052689]	membrane [GO:0016020]; carboxylic ester hydrolase activity [GO:0052689]	
Q5VVM6	reviewed	CCD30_HUMAN	Coiled-coil domain-containing protein 30 (Prefoldin subunit 6-like protein)	CCDC30 PFDN6L	Homo sapiens (Human)	783							
Q5VW22	reviewed	AGAP6_HUMAN	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6 (AGAP-6) (Centaurin-gamma-like family member 3)	AGAP6 CTGLF3	Homo sapiens (Human)	663	FUNCTION: Putative GTPase-activating protein. {ECO:0000305}.	MISCELLANEOUS: Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.; MISCELLANEOUS: [Isoform 1]: Prediction based on family homologs sequence.			GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	
Q5VWQ0	reviewed	RSBN1_HUMAN	Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1)	RSBN1	Homo sapiens (Human)	802	FUNCTION: Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. {ECO:0000250|UniProtKB:Q80T69}.			nucleus [GO:0005634]	histone H4K20 demethylase activity [GO:0035575]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; histone H4K20 demethylase activity [GO:0035575]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q5VX52	reviewed	SPAT1_HUMAN	Spermatogenesis-associated protein 1 (Sperm-specific protein SP-2)	SPATA1	Homo sapiens (Human)	459		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		acrosomal vesicle [GO:0001669]		acrosomal vesicle [GO:0001669]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9D5R4}.
Q5VXU3	reviewed	CHIC1_HUMAN	Cysteine-rich hydrophobic domain-containing protein 1 (Brain X-linked protein)	CHIC1 BRX	Homo sapiens (Human)	224				cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]		cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Also present at a Golgi-like vesicular compartment and at scattered vesicles. {ECO:0000250}.
Q5VYM1	reviewed	CI131_HUMAN	Uncharacterized protein C9orf131	C9orf131	Homo sapiens (Human)	1079	FUNCTION: Dispensable for normal development and fertility. {ECO:0000250|UniProtKB:Q3V0E1}.						
Q5VYV0	reviewed	FOXB2_HUMAN	Forkhead box protein B2	FOXB2	Homo sapiens (Human)	432	FUNCTION: Transcription factor. {ECO:0000305}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5VYV7	reviewed	SLX4I_HUMAN	Protein SLX4IP (SLX4-interacting protein)	SLX4IP C20orf94	Homo sapiens (Human)	408							
Q5VZ03	reviewed	NXNL2_HUMAN	Nucleoredoxin-like protein 2 (Rod-derived cone viability factor 2) (RdCVF2)	NXNL2 C9orf121	Homo sapiens (Human)	156	FUNCTION: May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons. {ECO:0000250}.		photoreceptor cell maintenance [GO:0045494]; sensory perception of smell [GO:0007608]; visual perception [GO:0007601]			photoreceptor cell maintenance [GO:0045494]; sensory perception of smell [GO:0007608]; visual perception [GO:0007601]	
Q5VZ46	reviewed	K1614_HUMAN	Uncharacterized protein KIAA1614	KIAA1614	Homo sapiens (Human)	1190			centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; regulation of cellular localization [GO:0060341]	apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; nucleus [GO:0005634]		apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; nucleus [GO:0005634]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; regulation of cellular localization [GO:0060341]	
Q5VZ66	reviewed	JKIP3_HUMAN	Janus kinase and microtubule-interacting protein 3 (Neuroendocrine long coiled-coil protein 2)	JAKMIP3 C10orf14 C10orf39 JAMIP3 NECC2	Homo sapiens (Human)	844				Golgi apparatus [GO:0005794]	kinase binding [GO:0019900]; microtubule binding [GO:0008017]	Golgi apparatus [GO:0005794]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}.
Q5W041	reviewed	ARMC3_HUMAN	Armadillo repeat-containing protein 3 (Beta-catenin-like protein) (Cancer/testis antigen 81) (CT81) (KU-CT-1)	ARMC3	Homo sapiens (Human)	872				extracellular exosome [GO:0070062]		extracellular exosome [GO:0070062]	
Q5W0A0	reviewed	ERI6B_HUMAN	Glutamate-rich protein 6B (Protein FAM194B)	ERICH6B FAM194B	Homo sapiens (Human)	696							
Q5W0B7	reviewed	TM236_HUMAN	Transmembrane protein 236	TMEM236 FAM23A FAM23B	Homo sapiens (Human)	351				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5W0V3	reviewed	FHI2A_HUMAN	FHF complex subunit HOOK interacting protein 2A (FHIP2A)	FHIP2A FAM160B1 KIAA1600	Homo sapiens (Human)	765	FUNCTION: Required for proper functioning of the nervous system. {ECO:0000269|PubMed:31353455}.						
Q5W186	reviewed	CST9_HUMAN	Cystatin-9 (Cystatin-like molecule)	CST9 CLM CTES7A	Homo sapiens (Human)	159	FUNCTION: May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation (PubMed:12535658). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria (PubMed:23922243). {ECO:0000250|UniProtKB:Q9Z0H6, ECO:0000269|PubMed:12535658, ECO:0000269|PubMed:23922243}.		antimicrobial humoral response [GO:0019730]	extracellular space [GO:0005615]	cysteine-type endopeptidase inhibitor activity [GO:0004869]	extracellular space [GO:0005615]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; antimicrobial humoral response [GO:0019730]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12535658}. Note=May be targeted through the Golgi via the secretory pathway. {ECO:0000269|PubMed:12535658}.
Q5W5W9	reviewed	RES18_HUMAN	Regulated endocrine-specific protein 18	RESP18	Homo sapiens (Human)	228	FUNCTION: May play an important regulatory role in corticotrophs. {ECO:0000250}.	MISCELLANEOUS: [Isoform 3]: May be due to intron retention. {ECO:0000305}.		cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]		cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:P47940}. Golgi apparatus {ECO:0000250|UniProtKB:P47940}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:P47940}. Note=Found in the lumen of secretory vesicles (dense core vesicles, DCV). However, seems to be retained intracellularly and not secreted. {ECO:0000250|UniProtKB:P47939, ECO:0000250|UniProtKB:P47940}.
Q5XG99	reviewed	LYSM4_HUMAN	LysM and putative peptidoglycan-binding domain-containing protein 4	LYSMD4	Homo sapiens (Human)	296				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5XKK7	reviewed	F219B_HUMAN	Protein FAM219B	FAM219B C15orf17	Homo sapiens (Human)	198							
Q5XKR9	reviewed	F104B_HUMAN	Protein FAM104B	FAM104B CXorf44	Homo sapiens (Human)	115							
Q5XUX1	reviewed	FBXW9_HUMAN	F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9)	FBXW9 FBW9	Homo sapiens (Human)	458	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.			cytosol [GO:0005829]		cytosol [GO:0005829]	
Q5YKI7	reviewed	GGNB1_HUMAN	Putative gametogenetin-binding protein 1	GGNBP1	Homo sapiens (Human)	109	FUNCTION: May be involved in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]		Golgi apparatus [GO:0005794]; membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus {ECO:0000250}.
Q63HM2	reviewed	PCX4_HUMAN	Pecanex-like protein 4 (Hepatitis C virus F protein-binding protein 2) (HCV F protein-binding protein 2) (Pecanex homolog protein 4)	PCNX4 C14orf135 FBP2 PCNXL4	Homo sapiens (Human)	1172				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q63HM9	reviewed	PLCX3_HUMAN	PI-PLC X domain-containing protein 3	PLCXD3	Homo sapiens (Human)	321			lipid catabolic process [GO:0016042]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; synapse [GO:0045202]	phosphoric diester hydrolase activity [GO:0008081]	cytoplasm [GO:0005737]; synapse [GO:0045202]; phosphoric diester hydrolase activity [GO:0008081]; lipid catabolic process [GO:0016042]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22732399}.
Q63ZE4	reviewed	S22AA_HUMAN	Solute carrier family 22 member 10 (Organic anion transporter 5)	SLC22A10 OAT5	Homo sapiens (Human)	541			organic anion transport [GO:0015711]	membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]; organic anion transport [GO:0015711]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q64ET8	reviewed	FRG2_HUMAN	Protein FRG2 (FSHD region gene 2 protein)	FRG2 FRG2A	Homo sapiens (Human)	278				nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15520407}.
Q658K8	reviewed	EF1DL_HUMAN	Putative elongation factor 1-delta-like protein (Putative EF-1-delta-like pseudogene 3 protein)	EEF1DP3	Homo sapiens (Human)	133					translation elongation factor activity [GO:0003746]	translation elongation factor activity [GO:0003746]	
Q658L1	reviewed	SAXO2_HUMAN	Stabilizer of axonemal microtubules 2	SAXO2 FAM154B	Homo sapiens (Human)	398				axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126]	microtubule binding [GO:0008017]	axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126]; microtubule binding [GO:0008017]	
Q658N2	reviewed	WSCD1_HUMAN	Sialate:O-sulfotransferase 1 (WSC domain-containing protein 1)	WSCD1 KIAA0523	Homo sapiens (Human)	575	FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. {ECO:0000250|UniProtKB:Q80XH4}.			Golgi membrane [GO:0000139]	sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]; sulfotransferase activity [GO:0008146]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q80XH4}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q80XH4}.
Q68CQ7	reviewed	GL8D1_HUMAN	Glycosyltransferase 8 domain-containing protein 1 (EC 2.4.1.-)	GLT8D1 GALA4A AD-017 MSTP137 UNQ572/PRO1134	Homo sapiens (Human)	371			organic substance metabolic process [GO:0071704]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	UDP-glycosyltransferase activity [GO:0008194]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; UDP-glycosyltransferase activity [GO:0008194]; organic substance metabolic process [GO:0071704]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q68CR1	reviewed	SE1L3_HUMAN	Protein sel-1 homolog 3 (Suppressor of lin-12-like protein 3) (Sel-1L3)	SEL1L3 KIAA0746	Homo sapiens (Human)	1132				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q68DI1	reviewed	ZN776_HUMAN	Zinc finger protein 776	ZNF776	Homo sapiens (Human)	518	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q68DN1	reviewed	CB016_HUMAN	Uncharacterized protein C2orf16	C2orf16	Homo sapiens (Human)	1984				extracellular exosome [GO:0070062]; nucleus [GO:0005634]		extracellular exosome [GO:0070062]; nucleus [GO:0005634]	
Q68DU8	reviewed	KCD16_HUMAN	BTB/POZ domain-containing protein KCTD16 (Potassium channel tetramerization domain-containing protein 16)	KCTD16 KIAA1317	Homo sapiens (Human)	428	FUNCTION: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250|UniProtKB:Q5DTY9}.		protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]		cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]; protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Presynaptic cell membrane. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q5DTY9}.
Q68DY9	reviewed	ZN772_HUMAN	Zinc finger protein 772	ZNF772	Homo sapiens (Human)	489	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q69YU3	reviewed	AN34A_HUMAN	Ankyrin repeat domain-containing protein 34A	ANKRD34A ANKRD34	Homo sapiens (Human)	496			piRNA processing [GO:0034587]	pi-body [GO:0071546]		pi-body [GO:0071546]; piRNA processing [GO:0034587]	
Q6AHZ1	reviewed	Z518A_HUMAN	Zinc finger protein 518A	ZNF518A KIAA0335 ZNF518	Homo sapiens (Human)	1483	FUNCTION: Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes. {ECO:0000250|UniProtKB:B2RRF6}.		chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B2RRF6}.
Q6AI08	reviewed	HEAT6_HUMAN	HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1)	HEATR6 ABC1	Homo sapiens (Human)	1181	FUNCTION: Amplification-dependent oncogene.	MISCELLANEOUS: 17q23 region is one of the most commonly amplified regions in breast cancer and therefore may harbor genes important for breast cancer development and progression.			RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q6AI12	reviewed	ANR40_HUMAN	Ankyrin repeat domain-containing protein 40	ANKRD40	Homo sapiens (Human)	368							
Q6AW86	reviewed	Z324B_HUMAN	Zinc finger protein 324B	ZNF324B	Homo sapiens (Human)	544	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6B0B8	reviewed	TIGD3_HUMAN	Tigger transposable element-derived protein 3	TIGD3	Homo sapiens (Human)	471				nucleus [GO:0005634]	DNA binding [GO:0003677]	nucleus [GO:0005634]; DNA binding [GO:0003677]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000255|PROSITE-ProRule:PRU00583}.
Q6BEB4	reviewed	SP5_HUMAN	Transcription factor Sp5	SP5	Homo sapiens (Human)	398	FUNCTION: Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity). {ECO:0000250}.		bone morphogenesis [GO:0060349]; cellular response to organic cyclic compound [GO:0071407]; post-anal tail morphogenesis [GO:0036342]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; bone morphogenesis [GO:0060349]; cellular response to organic cyclic compound [GO:0071407]; post-anal tail morphogenesis [GO:0036342]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q6DD87	reviewed	ZN787_HUMAN	Zinc finger protein 787 (TTF-I-interacting peptide 20)	ZNF787	Homo sapiens (Human)	382	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6DHV5	reviewed	C2D2B_HUMAN	Protein CC2D2B	CC2D2B C10orf130 C10orf131	Homo sapiens (Human)	1437			non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]	ciliary transition zone [GO:0035869]		ciliary transition zone [GO:0035869]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]	
Q6DKI1	reviewed	RL7L_HUMAN	Ribosomal protein uL30-like (60S ribosomal protein L7-like 1) (Large ribosomal subunit protein uL30-like 1)	RPL7L1	Homo sapiens (Human)	255			blastocyst formation [GO:0001825]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]	cytosolic large ribosomal subunit [GO:0022625]; nucleolus [GO:0005730]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; blastocyst formation [GO:0001825]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]	
Q6EBC2	reviewed	IL31_HUMAN	Interleukin-31 (IL-31)	IL31	Homo sapiens (Human)	164	FUNCTION: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity). {ECO:0000250|UniProtKB:Q6EAL8, ECO:0000269|PubMed:15184896}.		immune system process [GO:0002376]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; immune system process [GO:0002376]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6EKJ0	reviewed	GTD2B_HUMAN	General transcription factor II-I repeat domain-containing protein 2B (GTF2I repeat domain-containing protein 2B) (Transcription factor GTF2IRD2-beta)	GTF2IRD2B	Homo sapiens (Human)	949				nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	SUBCELLULAR LOCATION: Nucleus.
Q6F5E7	reviewed	TR3N_HUMAN	Putative uncharacterized protein TXNRD3NB (Thioredoxin reductase 2 intronic transcript 1) (Thioredoxin reductase 3 intronic transcript 1) (Thioredoxin reductase 3 neighbor gene protein) (TXNRD3 neighbor gene protein) (Thioredoxin reductase 3 new transcript 1)	TXNRD3NB TR2IT1 TXNRD3IT1 TXNRD3NT1	Homo sapiens (Human)	133							
Q6GPI1	reviewed	CTRB2_HUMAN	Chymotrypsinogen B2 (EC 3.4.21.1) [Cleaved into: Chymotrypsin B2 chain A; Chymotrypsin B2 chain B; Chymotrypsin B2 chain C]	CTRB2	Homo sapiens (Human)	263			digestion [GO:0007586]; proteolysis [GO:0006508]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; digestion [GO:0007586]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted, extracellular space.
Q6ICC9	reviewed	RTL6_HUMAN	Retrotransposon Gag-like protein 6 (Leucine zipper protein down-regulated in cancer cells-like) (Mammalian retrotransposon-derived protein 6) (Protein LDOC1L)	RTL6 LDOC1L MAR6 MART6	Homo sapiens (Human)	239		MISCELLANEOUS: RTL6 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. {ECO:0000269|PubMed:16093683}.					
Q6ICG6	reviewed	K0930_HUMAN	Uncharacterized protein KIAA0930	KIAA0930 C22orf9	Homo sapiens (Human)	404							
Q6ICH7	reviewed	ASPH2_HUMAN	Aspartate beta-hydroxylase domain-containing protein 2 (EC 1.14.11.-)	ASPHD2	Homo sapiens (Human)	369	FUNCTION: May function as 2-oxoglutarate-dependent dioxygenase. {ECO:0000250}.			membrane [GO:0016020]	dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872]	membrane [GO:0016020]; dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q6IEE8	reviewed	SN12L_HUMAN	Schlafen family member 12-like	SLFN12L SLFN5	Homo sapiens (Human)	588				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.
Q6IEU7	reviewed	OR5MA_HUMAN	Olfactory receptor 5M10 (Olfactory receptor OR11-207)	OR5M10	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6IEV9	reviewed	OR4CB_HUMAN	Olfactory receptor 4C11 (Olfactory receptor OR11-136)	OR4C11 OR4C11P	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6IEY1	reviewed	OR4F3_HUMAN	Olfactory receptor 4F3/4F16/4F29 (Olfactory receptor OR1-1)	OR4F3; OR4F16; OR4F29	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6IEZ7	reviewed	OR2T5_HUMAN	Olfactory receptor 2T5 (Olfactory receptor OR1-62)	OR2T5	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6IF00	reviewed	OR2T2_HUMAN	Olfactory receptor 2T2 (Olfactory receptor OR1-43)	OR2T2 OR2T2P	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6IF36	reviewed	O8G2P_HUMAN	Putative olfactory receptor 8G2 (Olfactory receptor 8G4) (Olfactory receptor OR11-292) (Olfactory receptor TPCR120)	OR8G2P OR8G2 OR8G4	Homo sapiens (Human)	304	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q6IF42	reviewed	OR2A2_HUMAN	Olfactory receptor 2A2 (Olfactory receptor 2A17) (Olfactory receptor OR7-11)	OR2A2 OR2A17P OR2A2P	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6IF63	reviewed	O52W1_HUMAN	Olfactory receptor 52W1 (Olfactory receptor OR11-71)	OR52W1 OR52W1P	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6IF82	reviewed	O4A47_HUMAN	Olfactory receptor 4A47 (Olfactory receptor OR11-113)	OR4A47	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6IF99	reviewed	O10K2_HUMAN	Olfactory receptor 10K2 (Olfactory receptor OR1-4)	OR10K2	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6IFG1	reviewed	O52E8_HUMAN	Olfactory receptor 52E8 (Olfactory receptor OR11-54)	OR52E8	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6IFN5	reviewed	O7E24_HUMAN	Olfactory receptor 7E24 (Olfactory receptor OR19-14)	OR7E24 OR7E24P	Homo sapiens (Human)	339	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6IN97	reviewed	FRP2L_HUMAN	Putative protein FRMPD2-like (FERM and PDZ domain-containing protein 2 pseudogene 1) (FERM and PDZ domain-containing protein 2B pseudogene) (PDZ domain-containing protein 5A)	FRMPD2B FRMPD2L1 FRMPD2L2 FRMPD2P1 FRMPD2P2 PDZD5A PDZD5B PDZK5A PDZK5B	Homo sapiens (Human)	320							
Q6IPT2	reviewed	GAR5A_HUMAN	Golgi-associated RAB2 interactor protein 5A	GARIN5A FAM71E1	Homo sapiens (Human)	247	FUNCTION: RAB2B effector protein which promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis. {ECO:0000250|UniProtKB:A1L3C1}.		defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of type I interferon production [GO:0032481]	Golgi apparatus [GO:0005794]		Golgi apparatus [GO:0005794]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of type I interferon production [GO:0032481]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:A1L3C1}.
Q6IPX1	reviewed	TBC3C_HUMAN	TBC1 domain family member 3C	TBC1D3C TBC1D3D	Homo sapiens (Human)	549	FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250}.	MISCELLANEOUS: TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor. {ECO:0000305}.		plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associated with lipid rafts. {ECO:0000250}.
Q6IPX3	reviewed	TCAL6_HUMAN	Transcription elongation factor A protein-like 6 (TCEA-like protein 6) (Transcription elongation factor S-II protein-like 6)	TCEAL6	Homo sapiens (Human)	200	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6IQ21	reviewed	ZN770_HUMAN	Zinc finger protein 770	ZNF770	Homo sapiens (Human)	691	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6IS14	reviewed	IF5AL_HUMAN	Eukaryotic translation initiation factor 5A-1-like (eIF-5A-1-like) (eIF-5A1-like) (Eukaryotic initiation factor 5A isoform 1-like)	EIF5AL1	Homo sapiens (Human)	154	FUNCTION: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241}.		positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; translational elongation [GO:0006414]	endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]	endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; translational elongation [GO:0006414]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P63241}. Nucleus {ECO:0000250|UniProtKB:P63241}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P63241}; Peripheral membrane protein {ECO:0000250|UniProtKB:P63241}; Cytoplasmic side {ECO:0000250|UniProtKB:P63241}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250|UniProtKB:P63241}.
Q6J272	reviewed	CMI2A_HUMAN	Ciliary microtubule inner protein 2A	CIMIP2A FAM166A HSD46	Homo sapiens (Human)	317	FUNCTION: Probable microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. {ECO:0000250|UniProtKB:G3X6E2}.			ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleus [GO:0005634]		ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:G3X6E2}.
Q6JVE6	reviewed	LCN10_HUMAN	Epididymal-specific lipocalin-10	LCN10	Homo sapiens (Human)	187	FUNCTION: May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.			extracellular region [GO:0005576]	small molecule binding [GO:0036094]	extracellular region [GO:0005576]; small molecule binding [GO:0036094]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6JVE9	reviewed	LCN8_HUMAN	Epididymal-specific lipocalin-8	LCN8 LCN5	Homo sapiens (Human)	175	FUNCTION: May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.		response to hormone [GO:0009725]	extracellular region [GO:0005576]	small molecule binding [GO:0036094]	extracellular region [GO:0005576]; small molecule binding [GO:0036094]; response to hormone [GO:0009725]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q6L8G5	reviewed	KR510_HUMAN	Keratin-associated protein 5-10 (Keratin-associated protein 5.10) (Ultrahigh sulfur keratin-associated protein 5.10)	KRTAP5-10 KAP5.10 KRTAP5.10	Homo sapiens (Human)	202	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q6L9T8	reviewed	FA72D_HUMAN	Protein FAM72D (Gastric cancer up-regulated protein 2)	FAM72D GCUD2	Homo sapiens (Human)	149				cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]		cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]	
Q6MZZ7	reviewed	CAN13_HUMAN	Calpain-13 (EC 3.4.22.-) (Calcium-activated neutral proteinase 13) (CANP 13)	CAPN13	Homo sapiens (Human)	669	FUNCTION: Probable non-lysosomal thiol-protease. {ECO:0000250}.		proteolysis [GO:0006508]	cytoplasm [GO:0005737]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cytoplasm [GO:0005737]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; proteolysis [GO:0006508]	
Q6NSI8	reviewed	SANBR_HUMAN	SANT and BTB domain regulator of class switch recombination (SANT and BTB domain regulator of CSR)	SANBR KIAA1841	Homo sapiens (Human)	718	FUNCTION: Negatively regulates class switch recombination or isotype switching in splenic B-cells. {ECO:0000250|UniProtKB:Q68FF0}.		isotype switching [GO:0045190]		identical protein binding [GO:0042802]	identical protein binding [GO:0042802]; isotype switching [GO:0045190]	
Q6NSJ2	reviewed	PHLB3_HUMAN	Pleckstrin homology-like domain family B member 3	PHLDB3	Homo sapiens (Human)	640					enzyme binding [GO:0019899]	enzyme binding [GO:0019899]	
Q6NSW5	reviewed	DE10B_HUMAN	Putative DENN domain-containing protein 10 B (DENND10 pseudogene 1) (Putative protein FAM45B)	DENND10P1 FAM45 FAM45BP HT011	Homo sapiens (Human)	357	FUNCTION: May be a guanine nucleotide exchange factor (GEF). {ECO:0000250|UniProtKB:Q8TCE6}.		protein transport [GO:0015031]; regulation of early endosome to late endosome transport [GO:2000641]	late endosome [GO:0005770]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	late endosome [GO:0005770]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; protein transport [GO:0015031]; regulation of early endosome to late endosome transport [GO:2000641]	SUBCELLULAR LOCATION: Late endosome {ECO:0000250|UniProtKB:Q8TCE6}.
Q6NT04	reviewed	TIGD7_HUMAN	Tigger transposable element-derived protein 7	TIGD7	Homo sapiens (Human)	549				nucleus [GO:0005634]	DNA binding [GO:0003677]	nucleus [GO:0005634]; DNA binding [GO:0003677]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6NT52	reviewed	CGB2_HUMAN	Choriogonadotropin subunit beta variant 2	CGB2	Homo sapiens (Human)	163		MISCELLANEOUS: Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates. {ECO:0000269|PubMed:11861891}.	G protein-coupled receptor signaling pathway [GO:0007186]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]	hormone activity [GO:0005179]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Secreted.
Q6NT89	reviewed	TRNP1_HUMAN	TMF-regulated nuclear protein 1	TRNP1 C1orf225 TRNP	Homo sapiens (Human)	227	FUNCTION: DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points (By similarity). {ECO:0000250}.		cell cycle [GO:0007049]; cerebellar cortex morphogenesis [GO:0021696]; neural precursor cell proliferation [GO:0061351]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]	euchromatin [GO:0000791]; nucleus [GO:0005634]	DNA binding [GO:0003677]	euchromatin [GO:0000791]; nucleus [GO:0005634]; DNA binding [GO:0003677]; cell cycle [GO:0007049]; cerebellar cortex morphogenesis [GO:0021696]; neural precursor cell proliferation [GO:0061351]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q6NUN7	reviewed	JHY_HUMAN	Jhy protein homolog	JHY C11orf63	Homo sapiens (Human)	778	FUNCTION: Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. {ECO:0000250|UniProtKB:E9Q793}.		axoneme assembly [GO:0035082]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cerebrospinal fluid circulation [GO:0090660]; establishment of localization in cell [GO:0051649]; motile cilium assembly [GO:0044458]; regulation of establishment of planar polarity [GO:0090175]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; axoneme assembly [GO:0035082]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cerebrospinal fluid circulation [GO:0090660]; establishment of localization in cell [GO:0051649]; motile cilium assembly [GO:0044458]; regulation of establishment of planar polarity [GO:0090175]	
Q6NV75	reviewed	GP153_HUMAN	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1)	GPR153 PGR1	Homo sapiens (Human)	609	FUNCTION: Orphan receptor.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q6NVV3	reviewed	NIPA3_HUMAN	Magnesium transporter NIPA3 (NIPA-like protein 1) (Non-imprinted in Prader-Willi/Angelman syndrome region protein 3)	NIPAL1 NIPA3 NPAL1	Homo sapiens (Human)	410	FUNCTION: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). {ECO:0000250|UniProtKB:Q8BMW7}.		magnesium ion transport [GO:0015693]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	magnesium ion transmembrane transporter activity [GO:0015095]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; magnesium ion transmembrane transporter activity [GO:0015095]; magnesium ion transport [GO:0015693]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8BMW7}; Multi-pass membrane protein {ECO:0000255}.
Q6NVV9	reviewed	ADAM5_HUMAN	Putative disintegrin and metalloproteinase domain-containing protein 5 (Putative transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (tMDC II)	ADAM5 ADAM5P TMDC2	Homo sapiens (Human)	412	FUNCTION: This is a non catalytic metalloprotease-like protein. {ECO:0000250, ECO:0000269|PubMed:10417343}.						
Q6NW29	reviewed	RWDD4_HUMAN	RWD domain-containing protein 4 (Protein FAM28A)	RWDD4 FAM28A RWDD4A	Homo sapiens (Human)	188							
Q6NX49	reviewed	ZN544_HUMAN	Zinc finger protein 544	ZNF544	Homo sapiens (Human)	715	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6NXP0	reviewed	EFC12_HUMAN	EF-hand calcium-binding domain-containing protein 12	EFCAB12 C3orf25	Homo sapiens (Human)	572					calcium ion binding [GO:0005509]	calcium ion binding [GO:0005509]	
Q6NXP2	reviewed	GAR1A_HUMAN	Golgi-associated RAB2 interactor protein 1A	GARIN1A FAM137B FAM71F2	Homo sapiens (Human)	309	FUNCTION: RAB2B effector protein required for accurate acrosome formation and normal male fertility. {ECO:0000250|UniProtKB:B2RXB0}.		acrosome assembly [GO:0001675]	Golgi apparatus [GO:0005794]		Golgi apparatus [GO:0005794]; acrosome assembly [GO:0001675]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:B2RXB0}.
Q6NXT1	reviewed	ANR54_HUMAN	Ankyrin repeat domain-containing protein 54 (Lyn-interacting ankyrin repeat protein)	ANKRD54 LIAR	Homo sapiens (Human)	300	FUNCTION: Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. {ECO:0000250}.		nucleocytoplasmic transport [GO:0006913]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of intracellular signal transduction [GO:1902531]	cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleus [GO:0005634]	protein kinase regulator activity [GO:0019887]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleus [GO:0005634]; protein kinase regulator activity [GO:0019887]; protein-containing complex binding [GO:0044877]; nucleocytoplasmic transport [GO:0006913]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of intracellular signal transduction [GO:1902531]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Midbody {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation (By similarity). {ECO:0000250}.
Q6NZ63	reviewed	STEAL_HUMAN	STEAP family member 1B	STEAP1B	Homo sapiens (Human)	245				endosome [GO:0005768]; plasma membrane [GO:0005886]		endosome [GO:0005768]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6P093	reviewed	ADCL2_HUMAN	Arylacetamide deacetylase-like 2 (EC 3.1.1.-)	AADACL2	Homo sapiens (Human)	401		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		extracellular region [GO:0005576]; membrane [GO:0016020]	carboxylic ester hydrolase activity [GO:0052689]	extracellular region [GO:0005576]; membrane [GO:0016020]; carboxylic ester hydrolase activity [GO:0052689]	SUBCELLULAR LOCATION: Secreted.
Q6P161	reviewed	RM54_HUMAN	Large ribosomal subunit protein mL54 (39S ribosomal protein L54, mitochondrial) (L54mt) (MRP-L54)	MRPL54	Homo sapiens (Human)	138			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q6P1N9	reviewed	TATD1_HUMAN	Deoxyribonuclease TATDN1 (EC 3.1.21.-) (Hepatocarcinoma high expression protein)	TATDN1 CDA11	Homo sapiens (Human)	297	FUNCTION: Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules (By similarity). Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity (By similarity). {ECO:0000250|UniProtKB:Q6GML7}.			nucleoplasm [GO:0005654]	3'-5'-DNA exonuclease activity [GO:0008296]; metal ion binding [GO:0046872]	nucleoplasm [GO:0005654]; 3'-5'-DNA exonuclease activity [GO:0008296]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6P280	reviewed	ZN529_HUMAN	Zinc finger protein 529	ZNF529 KIAA1615	Homo sapiens (Human)	563	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6P387	reviewed	CP046_HUMAN	Uncharacterized protein C16orf46	C16orf46	Homo sapiens (Human)	395				cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	
Q6P3R8	reviewed	NEK5_HUMAN	Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5)	NEK5	Homo sapiens (Human)	708			phosphorylation [GO:0016310]		ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; phosphorylation [GO:0016310]	
Q6P3V2	reviewed	Z585A_HUMAN	Zinc finger protein 585A	ZNF585A	Homo sapiens (Human)	769	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6P474	reviewed	PDXD2_HUMAN	Putative pyridoxal-dependent decarboxylase domain-containing protein 2 (EC 4.1.1.-) (pyridoxal-dependent decarboxylase domain-containing 2 pseudogene)	PDXDC2P PDXDC2	Homo sapiens (Human)	469			carboxylic acid metabolic process [GO:0019752]	intracellular membrane-bounded organelle [GO:0043231]	carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170]	intracellular membrane-bounded organelle [GO:0043231]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170]; carboxylic acid metabolic process [GO:0019752]	
Q6P5X7	reviewed	TMM71_HUMAN	Transmembrane protein 71	TMEM71	Homo sapiens (Human)	295				membrane [GO:0016020]; mitochondrion [GO:0005739]		membrane [GO:0016020]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6P6B1	reviewed	ERIC5_HUMAN	Glutamate-rich protein 5	ERICH5 C8orf47	Homo sapiens (Human)	374							
Q6P6B7	reviewed	ANR16_HUMAN	Ankyrin repeat domain-containing protein 16	ANKRD16	Homo sapiens (Human)	361	FUNCTION: Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. {ECO:0000250|UniProtKB:A2AS55}.		tRNA modification [GO:0006400]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; tRNA modification [GO:0006400]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2AS55}. Nucleus {ECO:0000250|UniProtKB:A2AS55}.
Q6P995	reviewed	F171B_HUMAN	Protein FAM171B	FAM171B KIAA1946 NPD019	Homo sapiens (Human)	826				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000250|UniProtKB:Q14CH0}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In neurons, localizes to vesicular-like puncta in the cytoplasm. {ECO:0000250|UniProtKB:Q14CH0}.
Q6P9A1	reviewed	ZN530_HUMAN	Zinc finger protein 530	ZNF530 KIAA1508	Homo sapiens (Human)	599	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6P9A3	reviewed	ZN549_HUMAN	Zinc finger protein 549	ZNF549	Homo sapiens (Human)	640	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6P9G0	reviewed	CB5D1_HUMAN	Cytochrome b5 domain-containing protein 1	CYB5D1	Homo sapiens (Human)	228	FUNCTION: Radial spoke stalk protein that binds heme under oxidizing conditions. Required for the coordinated beating of multiple cilia maybe by functioning in a redox signaling pathway. {ECO:0000250|UniProtKB:Q567I9}.		cilium movement [GO:0003341]; regulation of cilium beat frequency [GO:0003356]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	metal ion binding [GO:0046872]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; metal ion binding [GO:0046872]; cilium movement [GO:0003341]; regulation of cilium beat frequency [GO:0003356]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q567I9}. Note=Localizes to the radial spoke stalk. {ECO:0000250|UniProtKB:Q567I9}.
Q6PCB5	reviewed	RSBNL_HUMAN	Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein)	RSBN1L	Homo sapiens (Human)	846	FUNCTION: Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}.			nucleus [GO:0005634]	dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9GRZ3}.
Q6PEW0	reviewed	PRS54_HUMAN	Inactive serine protease 54 (Cancer/testis antigen 67) (CT67) (Plasma kallikrein-like protein 4)	PRSS54 KLKBL4	Homo sapiens (Human)	395			proteolysis [GO:0006508]	extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]	extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6PEZ8	reviewed	PONL1_HUMAN	Podocan-like protein 1	PODNL1 SLRR5B	Homo sapiens (Human)	512				extracellular space [GO:0005615]		extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q6P3Y9}.
Q6PF15	reviewed	KLH35_HUMAN	Kelch-like protein 35	KLHL35	Homo sapiens (Human)	583							
Q6PG37	reviewed	ZN790_HUMAN	Zinc finger protein 790	ZNF790	Homo sapiens (Human)	636	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6PH81	reviewed	CP087_HUMAN	UPF0547 protein C16orf87	C16orf87	Homo sapiens (Human)	154							
Q6PI47	reviewed	KCD18_HUMAN	BTB/POZ domain-containing protein KCTD18	KCTD18	Homo sapiens (Human)	426			protein homooligomerization [GO:0051260]			protein homooligomerization [GO:0051260]	
Q6PI97	reviewed	HOATZ_HUMAN	Cilia- and flagella-associated protein HOATZ	HOATZ C11orf88 HOATZIN	Homo sapiens (Human)	169	FUNCTION: Required for motile ciliogenesis and flagellar genesis by mediating the maturation of the glycolytic enzyme ENO4. {ECO:0000250|UniProtKB:Q80Y73}.		axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283]	cilium [GO:0005929]; cytoplasm [GO:0005737]		cilium [GO:0005929]; cytoplasm [GO:0005737]; axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q80Y73}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80Y73}.
Q6PID6	reviewed	TTC33_HUMAN	Tetratricopeptide repeat protein 33 (TPR repeat protein 33) (Osmosis-responsive factor)	TTC33	Homo sapiens (Human)	262							
Q6PII5	reviewed	HAGHL_HUMAN	Hydroxyacylglutathione hydrolase-like protein (EC 3.1.2.-)	HAGHL	Homo sapiens (Human)	290	FUNCTION: Hydrolase acting on ester bonds. {ECO:0000305}.				hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872]	hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872]	
Q6PIV7	reviewed	S2534_HUMAN	Solute carrier family 25 member 34	SLC25A34	Homo sapiens (Human)	304	FUNCTION: Putative antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria. {ECO:0000269|PubMed:18682385}.		blastocyst hatching [GO:0001835]	mitochondrial inner membrane [GO:0005743]		mitochondrial inner membrane [GO:0005743]; blastocyst hatching [GO:0001835]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q6PJ61	reviewed	FBX46_HUMAN	F-box only protein 46 (F-box only protein 34-like)	FBXO46 FBX46 FBXO34L	Homo sapiens (Human)	603	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.						
Q6PJE2	reviewed	POZP3_HUMAN	POM121 and ZP3 fusion protein (POM-ZP3)	POMZP3	Homo sapiens (Human)	187				nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]		nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]	
Q6PK04	reviewed	CC137_HUMAN	Coiled-coil domain-containing protein 137	CCDC137 cPERP-B	Homo sapiens (Human)	289				chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleus [GO:0005634]	RNA binding [GO:0003723]	chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleus [GO:0005634]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:20813266}.
Q6PK81	reviewed	ZN773_HUMAN	Zinc finger protein 773 (Zinc finger protein 419B)	ZNF773 ZNF419B	Homo sapiens (Human)	442	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6PP77	reviewed	XKR2_HUMAN	XK-related protein 2 (Membrane protein XPLAC) (X Kell blood group-related, X-linked)	XKRX XKR2 XPLAC XRG2	Homo sapiens (Human)	449				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16431037}; Multi-pass membrane protein {ECO:0000269|PubMed:16431037}.
Q6Q6R5	reviewed	CRIP3_HUMAN	Cysteine-rich protein 3 (CRP-3) (Chromosome 6 LIM domain only protein) (h6LIMo)	CRIP3 CRP3	Homo sapiens (Human)	217				cytoplasm [GO:0005737]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q6S545	reviewed	POTEH_HUMAN	POTE ankyrin domain family member H (ANKRD26-like family C member 3) (Prostate, ovary, testis-expressed protein on chromosome 22) (POTE-22)	POTEH A26C3 ACTBL1 POTE22	Homo sapiens (Human)	545							
Q6S5H5	reviewed	POTEG_HUMAN	POTE ankyrin domain family member G (ANKRD26-like family C member 2) (Prostate, ovary, testis-expressed protein on chromosome 14) (POTE-14)	POTEG A26C2 POTE14	Homo sapiens (Human)	508		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q6S8J7	reviewed	POTEA_HUMAN	POTE ankyrin domain family member A (ANKRD26-like family A member 1) (Prostate, ovary, testis-expressed protein on chromosome 8) (POTE-8)	POTEA A26A1 POTE8	Homo sapiens (Human)	498							
Q6T423	reviewed	S22AP_HUMAN	Solute carrier family 22 member 25 (Organic anion transporter UST6)	SLC22A25 UST6	Homo sapiens (Human)	547			organic anion transport [GO:0015711]	membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]; organic anion transport [GO:0015711]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q6TFL3	reviewed	CC171_HUMAN	Coiled-coil domain-containing protein 171	CCDC171 C9orf93	Homo sapiens (Human)	1326							
Q6U949	reviewed	IG2AS_HUMAN	Putative insulin-like growth factor 2 antisense gene protein (IGF2 antisense RNA 1) (IGF2 antisense gene protein 1) (PEG8/IGF2AS protein) (Putative insulin-like growth factor 2 antisense gene protein 1) (IGF2-AS1)	IGF2-AS IGF2-AS1 IGF2AS	Homo sapiens (Human)	168							
Q6UE05	reviewed	TM270_HUMAN	Transmembrane protein 270 (Williams-Beuren syndrome chromosomal region 28 protein)	TMEM270 WBSCR28	Homo sapiens (Human)	265		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6UQ28	reviewed	PLET1_HUMAN	Placenta-expressed transcript 1 protein	PLET1 C11orf34	Homo sapiens (Human)	207	FUNCTION: Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; negative regulation of cell-matrix adhesion [GO:0001953]; positive regulation of cell migration [GO:0030335]; wound healing, spreading of epidermal cells [GO:0035313]	apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]		apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; cell differentiation [GO:0030154]; negative regulation of cell-matrix adhesion [GO:0001953]; positive regulation of cell migration [GO:0030335]; wound healing, spreading of epidermal cells [GO:0035313]	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Localized at the apical membrane of the most differentiated keratinocytes of the outer root sheath (ORS), clustered mainly in planar regions of the plasma membrane at the base of microvilli. {ECO:0000250}.
Q6UW01	reviewed	CBLN3_HUMAN	Cerebellin-3	CBLN3 UNQ755/PRO1486	Homo sapiens (Human)	205	FUNCTION: May be involved in synaptic functions in the CNS. {ECO:0000250}.		maintenance of synapse structure [GO:0099558]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; synapse [GO:0045202]		endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; synapse [GO:0045202]; maintenance of synapse structure [GO:0099558]	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, cis-Golgi network {ECO:0000250}. Secreted {ECO:0000250}. Synapse {ECO:0000250}. Note=In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on an association with CBLN1 and maybe CBLN4, but not on CBLN2 (By similarity). {ECO:0000250}.
Q6UW02	reviewed	CP20A_HUMAN	Cytochrome P450 20A1 (EC 1.14.-.-)	CYP20A1 UNQ667/PRO1301	Homo sapiens (Human)	462				membrane [GO:0016020]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	membrane [GO:0016020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6UW10	reviewed	SFTA2_HUMAN	Surfactant-associated protein 2 (Surfactant-associated protein G) (SP-G)	SFTA2 SFTPG UNQ541/PRO1098	Homo sapiens (Human)	78	FUNCTION: Putative surfactant protein. {ECO:0000305}.			extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; transport vesicle [GO:0030133]		extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; transport vesicle [GO:0030133]	SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:22768197}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:22768197}. Golgi apparatus {ECO:0000269|PubMed:22768197}.
Q6UWE3	reviewed	COLL2_HUMAN	Colipase-like protein 2	CLPSL2 C6orf126 UNQ3045/PRO9861	Homo sapiens (Human)	100			digestion [GO:0007586]; lipid catabolic process [GO:0016042]; response to food [GO:0032094]	extracellular region [GO:0005576]	enzyme activator activity [GO:0008047]	extracellular region [GO:0005576]; enzyme activator activity [GO:0008047]; digestion [GO:0007586]; lipid catabolic process [GO:0016042]; response to food [GO:0032094]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UWF7	reviewed	NXPE4_HUMAN	NXPE family member 4 (Protein FAM55D)	NXPE4 C11orf33 FAM55D UNQ3018/PRO9799	Homo sapiens (Human)	544				extracellular exosome [GO:0070062]		extracellular exosome [GO:0070062]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UWH4	reviewed	GAK1B_HUMAN	Golgi-associated kinase 1B (Expressed in nerve and epithelium during development) (Protein FAM198B)	GASK1B C4orf18 ENED FAM198B AD021 UNQ2512/PRO6001	Homo sapiens (Human)	519				Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]		Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:11256614}; Single-pass type II membrane protein {ECO:0000305|PubMed:11256614}.
Q6UWI4	reviewed	SHSA2_HUMAN	Protein shisa-2 homolog (Transmembrane protein 46)	SHISA2 C13orf13 TMEM46 UNQ9166/PRO28631	Homo sapiens (Human)	295	FUNCTION: Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. {ECO:0000250}.		negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of Wnt signaling pathway [GO:0030178]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of Wnt signaling pathway [GO:0030178]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q6UWJ8	reviewed	C16L2_HUMAN	CD164 sialomucin-like 2 protein	CD164L2 UNQ6122/PRO20044	Homo sapiens (Human)	174				cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]		cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6UWM9	reviewed	UD2A3_HUMAN	UDP-glucuronosyltransferase 2A3 (UDPGT 2A3) (EC 2.4.1.17)	UGT2A3 UNQ2559/PRO6239	Homo sapiens (Human)	527	FUNCTION: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). {ECO:0000250}.		cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]	membrane [GO:0016020]	glucuronosyltransferase activity [GO:0015020]	membrane [GO:0016020]; glucuronosyltransferase activity [GO:0015020]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6UWN0	reviewed	LYPD4_HUMAN	Ly6/PLAUR domain-containing protein 4	LYPD4 UNQ2552/PRO6181	Homo sapiens (Human)	246				extracellular region [GO:0005576]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; side of membrane [GO:0098552]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; side of membrane [GO:0098552]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Q6UWN8	reviewed	ISK6_HUMAN	Serine protease inhibitor Kazal-type 6 (Kallikrein inhibitor)	SPINK6 UNQ844/PRO1782	Homo sapiens (Human)	80	FUNCTION: Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8. {ECO:0000269|PubMed:20667819, ECO:0000269|PubMed:21439340}.			extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8BT20}.
Q6UWP8	reviewed	SBSN_HUMAN	Suprabasin	SBSN UNQ698/PRO1343	Homo sapiens (Human)	590				extracellular exosome [GO:0070062]		extracellular exosome [GO:0070062]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q6UWQ5	reviewed	LYZL1_HUMAN	Lysozyme-like protein 1 (EC 3.2.1.17)	LYZL1 LYC2 UNQ648/PRO1278	Homo sapiens (Human)	148			metabolic process [GO:0008152]	extracellular region [GO:0005576]	lysozyme activity [GO:0003796]	extracellular region [GO:0005576]; lysozyme activity [GO:0003796]; metabolic process [GO:0008152]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UWS5	reviewed	PT117_HUMAN	Protein PET117 homolog, mitochondrial	PET117 UNQ607/PRO1194	Homo sapiens (Human)	81			mitochondrial cytochrome c oxidase assembly [GO:0033617]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; mitochondrial cytochrome c oxidase assembly [GO:0033617]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22356826}.
Q6UWT2	reviewed	ENHO_HUMAN	Adropin (Energy homeostasis-associated protein)	ENHO C9orf165 UNQ470/PRO830	Homo sapiens (Human)	76	FUNCTION: Involved in the regulation of glucose homeostasis and lipid metabolism. {ECO:0000250}.		positive regulation of Notch signaling pathway [GO:0045747]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	hormone activity [GO:0005179]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; hormone activity [GO:0005179]; positive regulation of Notch signaling pathway [GO:0045747]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19041763}.
Q6UWU2	reviewed	GLB1L_HUMAN	Beta-galactosidase-1-like protein (EC 3.2.1.-)	GLB1L UNQ229/PRO262	Homo sapiens (Human)	654	FUNCTION: Probable glycosyl hydrolase. {ECO:0000305}.		carbohydrate metabolic process [GO:0005975]	extracellular region [GO:0005576]; lysosome [GO:0005764]; vacuole [GO:0005773]	beta-galactosidase activity [GO:0004565]	extracellular region [GO:0005576]; lysosome [GO:0005764]; vacuole [GO:0005773]; beta-galactosidase activity [GO:0004565]; carbohydrate metabolic process [GO:0005975]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UWV7	reviewed	SHL2A_HUMAN	Protein shisa-like-2A	SHISAL2A FAM159A UNQ2783/PRO7171	Homo sapiens (Human)	190		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6UWX4	reviewed	HIPL2_HUMAN	HHIP-like protein 2	HHIPL2 HHIP3 KIAA1822L UNQ841/PRO1779	Homo sapiens (Human)	724				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UWY5	reviewed	OLFL1_HUMAN	Olfactomedin-like protein 1	OLFML1 UNQ564/PRO1126	Homo sapiens (Human)	402			signal transduction [GO:0007165]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18708057}.
Q6UX68	reviewed	XKR5_HUMAN	XK-related protein 5	XKR5 XRG5 UNQ2754/PRO6493	Homo sapiens (Human)	686		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5GH66}; Multi-pass membrane protein {ECO:0000255}.
Q6UX72	reviewed	B3GN9_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 (BGnT-9) (Beta-1,3-Gn-T9) (Beta-1,3-N-acetylglucosaminyltransferase 9) (Beta3Gn-T9) (EC 2.4.1.-)	B3GNT9 UNQ1922/PRO4397	Homo sapiens (Human)	402			protein O-linked glycosylation [GO:0006493]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	hexosyltransferase activity [GO:0016758]; UDP-glycosyltransferase activity [GO:0008194]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; hexosyltransferase activity [GO:0016758]; UDP-glycosyltransferase activity [GO:0008194]; protein O-linked glycosylation [GO:0006493]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000255}.
Q6UX82	reviewed	LYPD8_HUMAN	Ly6/PLAUR domain-containing protein 8	LYPD8 UNQ511/PRO1026	Homo sapiens (Human)	237	FUNCTION: Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis. {ECO:0000250|UniProtKB:Q9D7S0}.		defense response to Gram-negative bacterium [GO:0050829]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; defense response to Gram-negative bacterium [GO:0050829]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9D7S0}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9D7S0}. Secreted {ECO:0000250|UniProtKB:Q9D7S0}. Note=Secreted into the lumen of the colon following cleavage of the GPI-anchor. {ECO:0000250|UniProtKB:Q9D7S0}.
Q6UXB1	reviewed	IGFL3_HUMAN	Insulin growth factor-like family member 3	IGFL3 UNQ483/PRO982	Homo sapiens (Human)	125	FUNCTION: Potential ligand of the IGFLR1 cell membrane receptor. {ECO:0000269|PubMed:21454693}.			extracellular space [GO:0005615]	signaling receptor binding [GO:0005102]	extracellular space [GO:0005615]; signaling receptor binding [GO:0005102]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UXB3	reviewed	LYPD2_HUMAN	Ly6/PLAUR domain-containing protein 2	LYPD2 LYPDC2 UNQ430/PRO788	Homo sapiens (Human)	125				extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Q6UXD7	reviewed	S49A3_HUMAN	Solute carrier family 49 member A3 (Major facilitator superfamily domain-containing protein 7) (Myosin light polypeptide 5 regulatory protein) (MYL5)	SLC49A3 MFSD7 LP2561 UNQ385/PRO717	Homo sapiens (Human)	560				membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6UXE8	reviewed	BTNL3_HUMAN	Butyrophilin-like protein 3 (Butyrophilin-like receptor)	BTNL3 BTNLR COLF4100 UNQ744/PRO1472	Homo sapiens (Human)	466			regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; signaling receptor binding [GO:0005102]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q6UXF7	reviewed	CL18B_HUMAN	C-type lectin domain family 18 member B (Mannose receptor-like protein 1)	CLEC18B MRLP1 UNQ306/PRO347	Homo sapiens (Human)	455	FUNCTION: Binds polysaccharides in a Ca(2+)-independent manner (By similarity). {ECO:0000250|UniProtKB:A5D8T8}.			endosome [GO:0005768]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; sarcoplasmic reticulum [GO:0016529]	polysaccharide binding [GO:0030247]	endosome [GO:0005768]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; sarcoplasmic reticulum [GO:0016529]; polysaccharide binding [GO:0030247]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A5D8T8}. Endoplasmic reticulum {ECO:0000305|PubMed:26170455}. Golgi apparatus {ECO:0000305|PubMed:26170455}. Endosome {ECO:0000305|PubMed:26170455}.
Q6UXN7	reviewed	TO20L_HUMAN	TOMM20-like protein 1	TOMM20L UNQ9438/PRO34772	Homo sapiens (Human)	152			protein import into mitochondrial matrix [GO:0030150]; tRNA import into mitochondrion [GO:0016031]	mitochondrial outer membrane translocase complex [GO:0005742]	mitochondrion targeting sequence binding [GO:0030943]	mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion targeting sequence binding [GO:0030943]; protein import into mitochondrial matrix [GO:0030150]; tRNA import into mitochondrion [GO:0016031]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6UXU4	reviewed	GSG1L_HUMAN	Germ cell-specific gene 1-like protein (GSG1-like protein)	GSG1L UNQ5831/PRO19651	Homo sapiens (Human)	331	FUNCTION: As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating. {ECO:0000250}.		regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]		glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Synapse {ECO:0000250}.
Q6UXU6	reviewed	TMM92_HUMAN	Transmembrane protein 92	TMEM92 UNQ5801/PRO19608	Homo sapiens (Human)	159				membrane [GO:0016020]; nucleoplasm [GO:0005654]		membrane [GO:0016020]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6UXV1	reviewed	IZUM2_HUMAN	Izumo sperm-egg fusion protein 2	IZUMO2 C19orf41 SCRL UNQ6978/PRO21961	Homo sapiens (Human)	221		MISCELLANEOUS: Izumo is the name of a Japanese shrine to marriage.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6UXY8	reviewed	TMC5_HUMAN	Transmembrane channel-like protein 5	TMC5 UNQ8238/PRO33604	Homo sapiens (Human)	1006	FUNCTION: Probable ion channel. {ECO:0000250}.			extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	mechanosensitive monoatomic ion channel activity [GO:0008381]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; mechanosensitive monoatomic ion channel activity [GO:0008381]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6UY01	reviewed	LRC31_HUMAN	Leucine-rich repeat-containing protein 31	LRRC31 UNQ9367/PRO34156	Homo sapiens (Human)	552							
Q6UY18	reviewed	LIGO4_HUMAN	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 (Leucine-rich repeat neuronal protein 6D)	LINGO4 LRRN6D UNQ9248/PRO34002	Homo sapiens (Human)	593			positive regulation of synapse assembly [GO:0051965]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; positive regulation of synapse assembly [GO:0051965]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6UY27	reviewed	PATE2_HUMAN	Prostate and testis expressed protein 2 (PATE-like protein M) (PATE-M)	PATE2 C11orf38 UNQ3112/PRO10144	Homo sapiens (Human)	113				extracellular space [GO:0005615]		extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6V702	reviewed	CF299_HUMAN	Cilia- and flagella-associated protein 299	CFAP299 C4orf22	Homo sapiens (Human)	233	FUNCTION: May be involved in spermatogenesis. {ECO:0000250|UniProtKB:Q810M1}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q810M1}. Nucleus {ECO:0000250|UniProtKB:Q810M1}. Note=Mainly cytoplasmic. {ECO:0000250|UniProtKB:Q810M1}.
Q6V9R5	reviewed	ZN562_HUMAN	Zinc finger protein 562	ZNF562	Homo sapiens (Human)	426	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6XE38	reviewed	SG1D4_HUMAN	Secretoglobin family 1D member 4 (IFN-gamma-inducible secretoglobin) (IIS)	SCGB1D4 UNQ517/PRO812	Homo sapiens (Human)	83	FUNCTION: Seems to be involved in the regulation of chemotactic cell migration and invasion.			extracellular space [GO:0005615]		extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted.
Q6XLA1	reviewed	CSC2A_HUMAN	Protein CASC2, isoform 3 (Cancer susceptibility candidate gene 2 protein, isoform 3)	CASC2 C10orf5	Homo sapiens (Human)	102	FUNCTION: May act as a potential tumor suppressor. {ECO:0000269|PubMed:15024726, ECO:0000269|PubMed:17352238}.		defense response to tumor cell [GO:0002357]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]			defense response to tumor cell [GO:0002357]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]	
Q6Y2X3	reviewed	DJC14_HUMAN	DnaJ homolog subfamily C member 14 (DnaJ protein homolog 3) (Dopamine receptor-interacting protein of 78 kDa) (DRIP78) (Human DnaJ protein 3) (hDj-3)	DNAJC14 DRIP78 HDJ3	Homo sapiens (Human)	702	FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000250}.		protein transport [GO:0015031]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	dopamine receptor binding [GO:0050780]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; dopamine receptor binding [GO:0050780]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q6ZMB5	reviewed	T184A_HUMAN	Transmembrane protein 184A	TMEM184A	Homo sapiens (Human)	413	FUNCTION: Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity). {ECO:0000250|UniProtKB:Q3UFJ6, ECO:0000250|UniProtKB:Q4QQS1}.			cytoplasmic vesicle membrane [GO:0030659]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]	heparin binding [GO:0008201]	cytoplasmic vesicle membrane [GO:0030659]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]; heparin binding [GO:0008201]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q4QQS1}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q4QQS1}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q1RMW2}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q3UFJ6}; Multi-pass membrane protein {ECO:0000255}. Endosome {ECO:0000250|UniProtKB:Q3UFJ6}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q3UFJ6}.
Q6ZMN7	reviewed	PZRN4_HUMAN	PDZ domain-containing RING finger protein 4 (Ligand of Numb protein X 4) (SEMACAP3-like protein)	PDZRN4 LNX4 SEMCAP3L	Homo sapiens (Human)	1036					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q6ZMN8	reviewed	CCNI2_HUMAN	Cyclin-I2	CCNI2	Homo sapiens (Human)	369			mitotic cell cycle phase transition [GO:0044772]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; mitotic cell cycle phase transition [GO:0044772]	
Q6ZMS4	reviewed	ZN852_HUMAN	Zinc finger protein 852	ZNF852	Homo sapiens (Human)	543	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q6ZMV5	reviewed	P4R3C_HUMAN	Protein PPP4R3C (SMEK homolog 3) (Serine/threonine-protein phosphatase 4 regulatory subunit 3C)	PPP4R3C PPP4R3CP SMEK3P	Homo sapiens (Human)	832			DNA damage response [GO:0006974]	nucleoplasm [GO:0005654]; protein phosphatase 4 complex [GO:0030289]	protein phosphatase activator activity [GO:0072542]	nucleoplasm [GO:0005654]; protein phosphatase 4 complex [GO:0030289]; protein phosphatase activator activity [GO:0072542]; DNA damage response [GO:0006974]	
Q6ZMW2	reviewed	ZN782_HUMAN	Zinc finger protein 782	ZNF782	Homo sapiens (Human)	699	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZMW3	reviewed	EMAL6_HUMAN	Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like)	EML6 EML5L	Homo sapiens (Human)	1958	FUNCTION: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. {ECO:0000250}.			cytoplasm [GO:0005737]; microtubule [GO:0005874]	microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule binding [GO:0008017]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
Q6ZMY6	reviewed	WDR88_HUMAN	WD repeat-containing protein 88 (PQQ repeat and WD repeat-containing protein)	WDR88 PQWD	Homo sapiens (Human)	472							
Q6ZMY9	reviewed	ZN517_HUMAN	Zinc finger protein 517	ZNF517	Homo sapiens (Human)	492	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZN01	reviewed	MASTR_HUMAN	MEF2-activating motif and SAP domain-containing transcriptional regulator (MEF2-activating SAP transcriptional regulatory protein)	MAMSTR MASTR	Homo sapiens (Human)	415	FUNCTION: Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity). {ECO:0000250}.		positive regulation of myotube differentiation [GO:0010831]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	transcription coregulator activity [GO:0003712]	nucleus [GO:0005634]; transcription coregulator activity [GO:0003712]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q6ZN06	reviewed	ZN813_HUMAN	Zinc finger protein 813	ZNF813	Homo sapiens (Human)	617	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZN08	reviewed	ZNF66_HUMAN	Putative zinc finger protein 66 (Zinc finger protein 66 pseudogene)	ZNF66 ZNF66P	Homo sapiens (Human)	573	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZN19	reviewed	ZN841_HUMAN	Zinc finger protein 841	ZNF841	Homo sapiens (Human)	808	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q6ZN32	reviewed	ETV3L_HUMAN	ETS translocation variant 3-like protein	ETV3L	Homo sapiens (Human)	361	FUNCTION: Transcriptional regulator. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
Q6ZN68	reviewed	D19P2_HUMAN	Putative C-mannosyltransferase DPY19L2P2 (EC 2.4.1.-) (Dpy-19-like protein 2 pseudogene 2) (Protein dpy-19 homolog 2-like 2)	DPY19L2P2	Homo sapiens (Human)	376	FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. {ECO:0000250}.		spermatid development [GO:0007286]	nuclear inner membrane [GO:0005637]	mannosyltransferase activity [GO:0000030]	nuclear inner membrane [GO:0005637]; mannosyltransferase activity [GO:0000030]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZN79	reviewed	Z705A_HUMAN	Zinc finger protein 705A	ZNF705A	Homo sapiens (Human)	300	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZN84	reviewed	CCD81_HUMAN	Coiled-coil domain-containing protein 81	CCDC81	Homo sapiens (Human)	652				centrosome [GO:0005813]; cytoplasm [GO:0005737]		centrosome [GO:0005813]; cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25074808}.
Q6ZNA1	reviewed	ZN836_HUMAN	Zinc finger protein 836	ZNF836	Homo sapiens (Human)	936	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZNA5	reviewed	FRRS1_HUMAN	Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2)	FRRS1 SDFR2 SDR2	Homo sapiens (Human)	592	FUNCTION: Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. {ECO:0000250|UniProtKB:Q8K385}.		intracellular iron ion homeostasis [GO:0006879]	membrane [GO:0016020]	metal ion binding [GO:0046872]; oxidoreductase activity, acting on metal ions [GO:0016722]	membrane [GO:0016020]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on metal ions [GO:0016722]; intracellular iron ion homeostasis [GO:0006879]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZNC4	reviewed	ZN704_HUMAN	Zinc finger protein 704	ZNF704	Homo sapiens (Human)	412	FUNCTION: Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ERQ3}.
Q6ZNF0	reviewed	ACP7_HUMAN	Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form)	ACP7 PAPL PAPL1	Homo sapiens (Human)	438				extracellular region [GO:0005576]	acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872]	extracellular region [GO:0005576]; acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6ZNG1	reviewed	ZN600_HUMAN	Zinc finger protein 600	ZNF600	Homo sapiens (Human)	722	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZNI0	reviewed	GCNT7_HUMAN	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 (EC 2.4.1.-)	GCNT7 C20orf105	Homo sapiens (Human)	430	FUNCTION: Glycosyltransferase. {ECO:0000250}.			Golgi membrane [GO:0000139]	acetylglucosaminyltransferase activity [GO:0008375]	Golgi membrane [GO:0000139]; acetylglucosaminyltransferase activity [GO:0008375]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q6ZNM6	reviewed	SMI10_HUMAN	Sperm-associated microtubule inner protein 10 (Testis-expressed protein 43)	SPMIP10 C5orf48 TEX43	Homo sapiens (Human)	134	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme, which is required for flagellum beating. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella (By similarity). Involved in the regulation of sperm motility (By similarity). {ECO:0000250|UniProtKB:A8SMG2, ECO:0000250|UniProtKB:Q9D9I1}.		flagellated sperm motility [GO:0030317]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]		cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; flagellated sperm motility [GO:0030317]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A8SMG2}. Note=Localizes at the ribbon and inner junction (IJ) between A- and B-tubules of the DMTs. {ECO:0000250|UniProtKB:A8SMG2}.
Q6ZNR0	reviewed	TMM91_HUMAN	Transmembrane protein 91 (Dispanin subfamily C member 3) (DSPC3)	TMEM91	Homo sapiens (Human)	172			hematopoietic progenitor cell differentiation [GO:0002244]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]		intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; hematopoietic progenitor cell differentiation [GO:0002244]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZP01	reviewed	RBM44_HUMAN	RNA-binding protein 44 (RNA-binding motif protein 44)	RBM44	Homo sapiens (Human)	1051	FUNCTION: Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility (By similarity). {ECO:0000250}.		mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]	mRNA 3'-UTR binding [GO:0003730]; protein homodimerization activity [GO:0042803]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; mRNA 3'-UTR binding [GO:0003730]; protein homodimerization activity [GO:0042803]; mRNA splicing, via spliceosome [GO:0000398]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Detected in the intercellular bridges. {ECO:0000250}.
Q6ZPB5	reviewed	SDIM1_HUMAN	Stress-responsive DNAJB4-interacting membrane protein 1	SDIM1	Homo sapiens (Human)	146	FUNCTION: Promotes neuronal cells survival to stress conditions. {ECO:0000269|PubMed:21255413}.		protein folding [GO:0006457]	membrane [GO:0016020]	protein homodimerization activity [GO:0042803]	membrane [GO:0016020]; protein homodimerization activity [GO:0042803]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZPD9	reviewed	D19L3_HUMAN	Probable C-mannosyltransferase DPY19L3 (EC 2.4.1.-) (Dpy-19-like protein 3) (Protein dpy-19 homolog 3)	DPY19L3	Homo sapiens (Human)	716	FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. {ECO:0000250}.			nuclear inner membrane [GO:0005637]	mannosyltransferase activity [GO:0000030]	nuclear inner membrane [GO:0005637]; mannosyltransferase activity [GO:0000030]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZQQ6	reviewed	WDR87_HUMAN	WD repeat-containing protein 87 (Testis development protein NYD-SP11)	WDR87	Homo sapiens (Human)	2873							
Q6ZR62	reviewed	RTL4_HUMAN	Retrotransposon Gag-like protein 4 (Mammalian retrotransposon-derived protein 4) (Zinc finger CCHC domain-containing protein 16)	RTL4 MAR3 MART4 ZCCHC16	Homo sapiens (Human)	310	FUNCTION: Involved in cognitive function in the brain, possibly via the noradrenergic system. {ECO:0000250|UniProtKB:Q3URY0}.	MISCELLANEOUS: RTL4 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. {ECO:0000269|PubMed:16093683}.	cognition [GO:0050890]; norepinephrine metabolic process [GO:0042415]		nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; cognition [GO:0050890]; norepinephrine metabolic process [GO:0042415]	
Q6ZRF7	reviewed	ZN818_HUMAN	Putative zinc finger protein 818	ZNF818P ZNF818	Homo sapiens (Human)	136	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZRI6	reviewed	CO039_HUMAN	Uncharacterized protein C15orf39	C15orf39 FP6578	Homo sapiens (Human)	1047				cytosol [GO:0005829]		cytosol [GO:0005829]	
Q6ZRI8	reviewed	RHG36_HUMAN	Rho GTPase-activating protein 36	ARHGAP36	Homo sapiens (Human)	547	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.		signal transduction [GO:0007165]		GTPase activator activity [GO:0005096]	GTPase activator activity [GO:0005096]; signal transduction [GO:0007165]	
Q6ZRR5	reviewed	TLCD5_HUMAN	TLC domain-containing protein 5 (Transmembrane protein 136)	TLCD5 TMEM136	Homo sapiens (Human)	245				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZRS4	reviewed	ITPI1_HUMAN	Protein ITPRID1 (Coiled-coil domain-containing protein 129) (ITPR-interacting domain-containing protein 1)	ITPRID1 CCDC129	Homo sapiens (Human)	1044					signaling receptor binding [GO:0005102]	signaling receptor binding [GO:0005102]	
Q6ZS11	reviewed	RINL_HUMAN	Ras and Rab interactor-like protein	RINL	Homo sapiens (Human)	566	FUNCTION: Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity). {ECO:0000250}.		endocytosis [GO:0006897]; protein transport [GO:0015031]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; ruffle [GO:0001726]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; ruffle [GO:0001726]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; endocytosis [GO:0006897]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cell projection, ruffle {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}.
Q6ZS30	reviewed	NBEL1_HUMAN	Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein)	NBEAL1 ALS2CR16 ALS2CR17	Homo sapiens (Human)	2694			protein localization [GO:0008104]	cytosol [GO:0005829]; membrane [GO:0016020]	protein kinase binding [GO:0019901]	cytosol [GO:0005829]; membrane [GO:0016020]; protein kinase binding [GO:0019901]; protein localization [GO:0008104]	
Q6ZS82	reviewed	R9BP_HUMAN	Regulator of G-protein signaling 9-binding protein (RGS9-anchoring protein)	RGS9BP R9AP	Homo sapiens (Human)	235	FUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity). {ECO:0000250}.		detection of light stimulus involved in visual perception [GO:0050908]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]	membrane [GO:0016020]; neuron projection [GO:0043005]		membrane [GO:0016020]; neuron projection [GO:0043005]; detection of light stimulus involved in visual perception [GO:0050908]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Q6ZS86	reviewed	GLPK5_HUMAN	Putative glycerol kinase 5 (GK 5) (Glycerokinase 5) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 5)	GK5	Homo sapiens (Human)	529			glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; glycerol-3-phosphate biosynthetic process [GO:0046167]; phosphorylation [GO:0016310]; triglyceride metabolic process [GO:0006641]	mitochondrion [GO:0005739]	ATP binding [GO:0005524]; glycerol kinase activity [GO:0004370]	mitochondrion [GO:0005739]; ATP binding [GO:0005524]; glycerol kinase activity [GO:0004370]; glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; glycerol-3-phosphate biosynthetic process [GO:0046167]; phosphorylation [GO:0016310]; triglyceride metabolic process [GO:0006641]	
Q6ZSI9	reviewed	CAN12_HUMAN	Calpain-12 (EC 3.4.22.-) (Calcium-activated neutral proteinase 12) (CANP 12)	CAPN12	Homo sapiens (Human)	719	FUNCTION: Calcium-regulated non-lysosomal thiol-protease. {ECO:0000250}.		proteolysis [GO:0006508]	cytoplasm [GO:0005737]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; proteolysis [GO:0006508]	
Q6ZSS3	reviewed	ZN621_HUMAN	Zinc finger protein 621	ZNF621	Homo sapiens (Human)	439	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZT07	reviewed	TBCD9_HUMAN	TBC1 domain family member 9 (TBC1 domain family member 9A)	TBC1D9 KIAA0882 TBC1D9A	Homo sapiens (Human)	1266	FUNCTION: May act as a GTPase-activating protein for Rab family protein(s).				calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096]	calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096]	
Q6ZT77	reviewed	ZN826_HUMAN	Putative zinc finger protein 826	ZNF826P ZNF826	Homo sapiens (Human)	177	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZTU2	reviewed	E400N_HUMAN	Putative EP400-like protein (EP400 pseudogene 1)	EP400P1 EP400NL	Homo sapiens (Human)	488							
Q6ZU65	reviewed	UBN2_HUMAN	Ubinuclein-2	UBN2 KIAA2030	Homo sapiens (Human)	1347				extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	
Q6ZU67	reviewed	BEND4_HUMAN	BEN domain-containing protein 4 (Coiled-coil domain-containing protein 4)	BEND4 CCDC4	Homo sapiens (Human)	534					DNA binding [GO:0003677]	DNA binding [GO:0003677]	
Q6ZU69	reviewed	S31F1_HUMAN	Protein SPATA31F1 (Protein FAM205A)	SPATA31F1 C9orf144B FAM205A	Homo sapiens (Human)	1335				membrane [GO:0016020]; nucleus [GO:0005634]		membrane [GO:0016020]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6ZUJ4	reviewed	CC062_HUMAN	Uncharacterized protein C3orf62	C3orf62	Homo sapiens (Human)	267	FUNCTION: Essential for normal spermatogenesis and male fertility. {ECO:0000250|UniProtKB:Q9D9C7}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]			cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	
Q6ZUK4	reviewed	TMM26_HUMAN	Transmembrane protein 26	TMEM26	Homo sapiens (Human)	368		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZUS6	reviewed	CC149_HUMAN	Coiled-coil domain-containing protein 149	CCDC149	Homo sapiens (Human)	474							
Q6ZUT6	reviewed	CCD9B_HUMAN	Coiled-coil domain-containing protein 9B	CCDC9B C15orf52	Homo sapiens (Human)	534					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q6ZV50	reviewed	RFX8_HUMAN	DNA-binding protein RFX8 (Regulatory factor X 8)	RFX8	Homo sapiens (Human)	586	FUNCTION: May be a transcription factor. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021914]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021914]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858}.
Q6ZV89	reviewed	SH2D5_HUMAN	SH2 domain-containing protein 5	SH2D5	Homo sapiens (Human)	423	FUNCTION: May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. {ECO:0000250|UniProtKB:Q8JZW5}.			postsynaptic density [GO:0014069]		postsynaptic density [GO:0014069]	SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250|UniProtKB:Q8JZW5}.
Q6ZVC0	reviewed	NYAP1_HUMAN	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1	NYAP1 C7orf51	Homo sapiens (Human)	841	FUNCTION: Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}.		neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]			neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction [GO:0043491]	
Q6ZVF9	reviewed	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth 3 (GRIN3)	GPRIN3 KIAA2027	Homo sapiens (Human)	776	FUNCTION: May be involved in neurite outgrowth. {ECO:0000250}.		neuron projection development [GO:0031175]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; neuron projection development [GO:0031175]	
Q6ZVL6	reviewed	K154L_HUMAN	UPF0606 protein KIAA1549L	KIAA1549L C11orf41 C11orf69	Homo sapiens (Human)	1849				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6ZVZ8	reviewed	ASB18_HUMAN	Ankyrin repeat and SOCS box protein 18 (ASB-18)	ASB18	Homo sapiens (Human)	466	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]		cytosol [GO:0005829]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	
Q6ZWB6	reviewed	KCTD8_HUMAN	BTB/POZ domain-containing protein KCTD8	KCTD8	Homo sapiens (Human)	473	FUNCTION: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}.		protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]		cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]; protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}.
Q719I0	reviewed	AHSA2_HUMAN	Putative activator of 90 kDa heat shock protein ATPase homolog 2 (Activator of HSP90 ATPase homolog 2 pseudogene)	AHSA2P AHSA2	Homo sapiens (Human)	299	FUNCTION: Co-chaperone that stimulates HSP90 ATPase activity. {ECO:0000250|UniProtKB:Q12449}.		protein folding [GO:0006457]	cytosol [GO:0005829]	ATPase activator activity [GO:0001671]; protein-folding chaperone binding [GO:0051087]	cytosol [GO:0005829]; ATPase activator activity [GO:0001671]; protein-folding chaperone binding [GO:0051087]; protein folding [GO:0006457]	
Q71RC9	reviewed	SMIM5_HUMAN	Small integral membrane protein 5	SMIM5 C17orf109	Homo sapiens (Human)	77				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q75NE6	reviewed	MIRH1_HUMAN	Putative microRNA 17 host gene protein (Putative microRNA host gene 1 protein)	MIR17HG C13orf25 MIRH1 MIRHG1	Homo sapiens (Human)	70		MISCELLANEOUS: The microRNAs that are encoded in a MIR17HG intron stimulate growth of cultured lung cancer cells.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q75VX8	reviewed	GARE2_HUMAN	GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like)	GAREM2 FAM59B GAREML KIAA2038 HRIHFB2063	Homo sapiens (Human)	874	FUNCTION: Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. {ECO:0000250}.						
Q765I0	reviewed	UTS2B_HUMAN	Urotensin-2B (Urotensin II-related peptide) (Urotensin IIB) (U-IIB) (UIIB) (Urotensin-2 domain-containing protein)	UTS2B URP UTS2D	Homo sapiens (Human)	119	FUNCTION: Potent vasoconstrictor. {ECO:0000250}.		blood vessel diameter maintenance [GO:0097746]; regulation of blood pressure [GO:0008217]	extracellular region [GO:0005576]	G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]	extracellular region [GO:0005576]; G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; blood vessel diameter maintenance [GO:0097746]; regulation of blood pressure [GO:0008217]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q76G19	reviewed	PDZD4_HUMAN	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein)	PDZD4 KIAA1444 PDZK4 PDZRN4L	Homo sapiens (Human)	769			proteolysis [GO:0006508]	cell cortex [GO:0005938]		cell cortex [GO:0005938]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:15077175}. Note=Mainly localized under the plasma membrane.
Q76KD6	reviewed	SPERI_HUMAN	Speriolin (Spermatogenesis and centriole-associated protein 1) (Spermatogenesis-associated protein 15) (Spermatogenic cell-specific Cdc20-binding protein)	SPATC1 SPATA15 SPRN	Homo sapiens (Human)	591				centrosome [GO:0005813]; cytoplasm [GO:0005737]		centrosome [GO:0005813]; cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with the centrosomal pericentrin protein PCNT1 (By similarity). Located in the connecting piece of sperm. {ECO:0000250, ECO:0000269|PubMed:20542897}.
Q76KX8	reviewed	ZN534_HUMAN	Zinc finger protein 534 (KRAB domain only protein 3)	ZNF534 KRBO3	Homo sapiens (Human)	674	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q7L0X2	reviewed	ERIP6_HUMAN	Glutamate-rich protein 6 (Protein FAM194A)	ERICH6 C3orf44 FAM194A	Homo sapiens (Human)	663							
Q7L211	reviewed	ABHDD_HUMAN	Protein ABHD13 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 13) (Abhydrolase domain-containing protein 13)	ABHD13 C13orf6	Homo sapiens (Human)	337				dendrite cytoplasm [GO:0032839]; membrane [GO:0016020]	palmitoyl-(protein) hydrolase activity [GO:0008474]	dendrite cytoplasm [GO:0032839]; membrane [GO:0016020]; palmitoyl-(protein) hydrolase activity [GO:0008474]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q7L311	reviewed	ARMX2_HUMAN	Armadillo repeat-containing X-linked protein 2 (ARM protein lost in epithelial cancers on chromosome X 2) (Protein ALEX2)	ARMCX2 ALEX2 KIAA0512	Homo sapiens (Human)	632	FUNCTION: May regulate the dynamics and distribution of mitochondria in neural cells. {ECO:0000250|UniProtKB:Q6A058}.			mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q6A058}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8BHS6}; Single-pass membrane protein {ECO:0000255}.
Q7L945	reviewed	ZN627_HUMAN	Zinc finger protein 627	ZNF627	Homo sapiens (Human)	461	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q7L985	reviewed	LIGO2_HUMAN	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (Leucine-rich repeat neuronal protein 3) (Leucine-rich repeat neuronal protein 6C)	LINGO2 LERN3 LRRN6C UNQ9234/PRO31993	Homo sapiens (Human)	606			positive regulation of synapse assembly [GO:0051965]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; positive regulation of synapse assembly [GO:0051965]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q7RTS6	reviewed	OTOP2_HUMAN	Proton channel OTOP2 (Otopetrin-2)	OTOP2	Homo sapiens (Human)	562	FUNCTION: Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. {ECO:0000250|UniProtKB:Q80SX5}.		proton transmembrane transport [GO:1902600]	plasma membrane [GO:0005886]	proton channel activity [GO:0015252]	plasma membrane [GO:0005886]; proton channel activity [GO:0015252]; proton transmembrane transport [GO:1902600]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80VM9}; Multi-pass membrane protein {ECO:0000255}.
Q7RTT3	reviewed	SSX9_HUMAN	Putative protein SSX9	SSX9P SSX9	Homo sapiens (Human)	188	FUNCTION: Could act as a modulator of transcription.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]		nucleus [GO:0005634]; regulation of DNA-templated transcription [GO:0006355]	
Q7RTT4	reviewed	SSX8_HUMAN	Putative protein SSX8	SSX8P SSX8	Homo sapiens (Human)	187	FUNCTION: Could act as a modulator of transcription.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]		nucleus [GO:0005634]; regulation of DNA-templated transcription [GO:0006355]	
Q7RTT5	reviewed	SSX7_HUMAN	Protein SSX7	SSX7	Homo sapiens (Human)	188	FUNCTION: Could act as a modulator of transcription.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]		nucleus [GO:0005634]; regulation of DNA-templated transcription [GO:0006355]	
Q7RTT6	reviewed	SSX6_HUMAN	Putative protein SSX6	SSX6P SSX6	Homo sapiens (Human)	188	FUNCTION: Could act as a modulator of transcription.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]		nucleus [GO:0005634]; regulation of DNA-templated transcription [GO:0006355]	
Q7RTU0	reviewed	TCF24_HUMAN	Transcription factor 24 (TCF-24)	TCF24	Homo sapiens (Human)	167	FUNCTION: Putative transcription factor. {ECO:0000250}.		developmental process [GO:0032502]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; developmental process [GO:0032502]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q7RTU5	reviewed	ASCL5_HUMAN	Achaete-scute homolog 5 (ASH-5) (hASH5) (Class A basic helix-loop-helix protein 47) (bHLHa47)	ASCL5 BHLHA47	Homo sapiens (Human)	278	FUNCTION: Transcription factor. Probably binds E-box motifs 5'-CANNTG-3' in complex with transcription factor TCF3/E12. Negatively modulates transcription of target genes such as CDH1/E-cadherin, perhaps by recruiting the PRC2 repressive complex to regulatory elements. Regulates ameloblast development and tooth germ growth, perhaps acting by positively modulating migration of inner enamel epithelium (IEE) cells. Plays a role in enamel formation. {ECO:0000250|UniProtKB:M0QWB7}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; RNA polymerase II transcription regulator complex [GO:0090575]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; RNA polymerase II transcription regulator complex [GO:0090575]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Q7RTV5	reviewed	PXL2C_HUMAN	Peroxiredoxin-like 2C (AhpC/TSA antioxidant enzyme domain-containing protein 1) (Thioredoxin-like protein AAED1)	PRXL2C AAED1 C9orf21	Homo sapiens (Human)	226	FUNCTION: May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis. {ECO:0000269|PubMed:29901208}.		positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glycolytic process [GO:0045821]			positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glycolytic process [GO:0045821]	
Q7RTX9	reviewed	MOT14_HUMAN	Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14)	SLC16A14 MCT14	Homo sapiens (Human)	510	FUNCTION: Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. {ECO:0000250}.		monocarboxylic acid transport [GO:0015718]	plasma membrane [GO:0005886]	monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]	plasma membrane [GO:0005886]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293]; monocarboxylic acid transport [GO:0015718]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q7RTY3	reviewed	PRS45_HUMAN	Putative serine protease 45 (EC 3.4.21.-) (Serine protease 45, pseudogene) (Testis serine protease 5)	PRSS45P PRSS45 TESSP5	Homo sapiens (Human)	260			proteolysis [GO:0006508]	extracellular space [GO:0005615]	serine-type endopeptidase activity [GO:0004252]	extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	
Q7Z2Q7	reviewed	LRR70_HUMAN	Leucine-rich repeat-containing protein 70 (Synleurin)	LRRC70 UNQ1891/PRO4337	Homo sapiens (Human)	622	FUNCTION: Renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS). {ECO:0000269|PubMed:12767927}.		positive regulation of response to cytokine stimulus [GO:0060760]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; positive regulation of response to cytokine stimulus [GO:0060760]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q7Z2Y8	reviewed	GVIN1_HUMAN	Interferon-induced very large GTPase 1 (Interferon-induced very large GTPase pseudogene 1)	GVINP1 GVIN1 VLIG1	Homo sapiens (Human)	2422				cytosol [GO:0005829]; nucleus [GO:0005634]	GTP binding [GO:0005525]	cytosol [GO:0005829]; nucleus [GO:0005634]; GTP binding [GO:0005525]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.
Q7Z304	reviewed	MAMC2_HUMAN	MAM domain-containing protein 2 (MAM domain-containing proteoglycan) (Mamcan)	MAMDC2	Homo sapiens (Human)	686			nervous system development [GO:0007399]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]		endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q7Z309	reviewed	PBIR2_HUMAN	PABIR family member 2	PABIR2 FAM122B	Homo sapiens (Human)	247					protein serine/threonine phosphatase inhibitor activity [GO:0004865]	protein serine/threonine phosphatase inhibitor activity [GO:0004865]	
Q7Z388	reviewed	D19L4_HUMAN	Probable C-mannosyltransferase DPY19L4 (EC 2.4.1.-) (Dpy-19-like protein 4) (Protein dpy-19 homolog 4)	DPY19L4	Homo sapiens (Human)	723	FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. {ECO:0000250}.			nuclear inner membrane [GO:0005637]	mannosyltransferase activity [GO:0000030]	nuclear inner membrane [GO:0005637]; mannosyltransferase activity [GO:0000030]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q7Z3E2	reviewed	CC186_HUMAN	Coiled-coil domain-containing protein 186 (CTCL tumor antigen HD-CL-01/L14-2)	CCDC186 C10orf118	Homo sapiens (Human)	898			insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; response to bacterium [GO:0009617]; vesicle cytoskeletal trafficking [GO:0099518]	trans-Golgi network [GO:0005802]	small GTPase binding [GO:0031267]	trans-Golgi network [GO:0005802]; small GTPase binding [GO:0031267]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; response to bacterium [GO:0009617]; vesicle cytoskeletal trafficking [GO:0099518]	
Q7Z3J3	reviewed	RGPD4_HUMAN	RanBP2-like and GRIP domain-containing protein 4	RGPD4 RGP4	Homo sapiens (Human)	1758		MISCELLANEOUS: One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.	NLS-bearing protein import into nucleus [GO:0006607]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]		cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; NLS-bearing protein import into nucleus [GO:0006607]	
Q7Z3V5	reviewed	ZN571_HUMAN	Zinc finger protein 571	ZNF571 HSPC059	Homo sapiens (Human)	609	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q7Z402	reviewed	TMC7_HUMAN	Transmembrane channel-like protein 7	TMC7	Homo sapiens (Human)	723	FUNCTION: Probable ion channel. {ECO:0000250}.			plasma membrane [GO:0005886]	mechanosensitive monoatomic ion channel activity [GO:0008381]	plasma membrane [GO:0005886]; mechanosensitive monoatomic ion channel activity [GO:0008381]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q7Z404	reviewed	TMC4_HUMAN	Transmembrane channel-like protein 4	TMC4	Homo sapiens (Human)	712	FUNCTION: Probable ion channel. {ECO:0000250}.			extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	mechanosensitive monoatomic ion channel activity [GO:0008381]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; mechanosensitive monoatomic ion channel activity [GO:0008381]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q7Z422	reviewed	SZRD1_HUMAN	SUZ domain-containing protein 1 (Putative MAPK-activating protein PM18/PM20/PM22)	SZRD1 C1orf144	Homo sapiens (Human)	152							
Q7Z4H9	reviewed	F220A_HUMAN	Protein FAM220A (STAT3-interacting protein as a repressor)	FAM220A C7orf70 SIPAR	Homo sapiens (Human)	259	FUNCTION: May negatively regulate STAT3. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	STAT family protein binding [GO:0097677]	nucleus [GO:0005634]; STAT family protein binding [GO:0097677]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q7Z4L0	reviewed	COX8C_HUMAN	Cytochrome c oxidase subunit 8C, mitochondrial (Cytochrome c oxidase polypeptide 8 isoform 3) (Cytochrome c oxidase polypeptide VIII isoform 3) (COX VIII-3) (Cytochrome c oxidase subunit 8-3) (COX8-3) (Cytochrome c oxidase subunit VIIIC)	COX8C	Homo sapiens (Human)	72	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10175}.		mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]		mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P10175}; Single-pass membrane protein {ECO:0000250|UniProtKB:P10175}.
Q7Z4L9	reviewed	PPR42_HUMAN	Protein phosphatase 1 regulatory subunit 42 (Leucine-rich repeat-containing protein 67)	PPP1R42 LRRC67	Homo sapiens (Human)	309	FUNCTION: Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis. {ECO:0000250|UniProtKB:Q8R1Z4}.			centrosome [GO:0005813]; cytoplasm [GO:0005737]; manchette [GO:0002177]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]	actin binding [GO:0003779]; dynein complex binding [GO:0070840]; tubulin binding [GO:0015631]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; manchette [GO:0002177]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; actin binding [GO:0003779]; dynein complex binding [GO:0070840]; tubulin binding [GO:0015631]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8R1Z4}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8R1Z4}. Note=Colocalizes with alpha tubulin to the manchette of developing spermatids. Detected to nuclear rim in pachytene spermatocytes. Detected at nuclear surface, opposite the acrosome in elongating spermatids. Detected at the microtubule-organizing center (MTOC). Localized to the centrosomal region of late-stage spermatids (By similarity). {ECO:0000250|UniProtKB:Q8R1Z4}.
Q7Z4M0	reviewed	RE114_HUMAN	Meiotic recombination protein REC114	REC114 C15orf60	Homo sapiens (Human)	266	FUNCTION: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. {ECO:0000250|UniProtKB:Q9CWH4}.		DNA recombination [GO:0006310]; meiotic cell cycle [GO:0051321]			DNA recombination [GO:0006310]; meiotic cell cycle [GO:0051321]	
Q7Z4R8	reviewed	CF120_HUMAN	UPF0669 protein C6orf120	C6orf120	Homo sapiens (Human)	191	FUNCTION: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes. {ECO:0000269|PubMed:22340178}.		apoptotic process [GO:0006915]	azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]		azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; apoptotic process [GO:0006915]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22340178}. Note=Secreted by hepatocytes.
Q7Z4Y8	reviewed	AT5L2_HUMAN	Putative ATP synthase subunit g 2, mitochondrial (ATPase subunit g 2) (ATP synthase membrane subunit g-like protein)	ATP5MGL ATP5K2 ATP5L2	Homo sapiens (Human)	100	FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity). {ECO:0000250}.		proton motive force-driven ATP synthesis [GO:0015986]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]	proton transmembrane transporter activity [GO:0015078]	mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]; proton transmembrane transporter activity [GO:0015078]; proton motive force-driven ATP synthesis [GO:0015986]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}.
Q7Z572	reviewed	SPT21_HUMAN	Spermatogenesis-associated protein 21	SPATA21	Homo sapiens (Human)	469	FUNCTION: Involved in the differentiation of haploid spermatids. {ECO:0000250}.				calcium ion binding [GO:0005509]	calcium ion binding [GO:0005509]	
Q7Z5A8	reviewed	TAFA3_HUMAN	Chemokine-like protein TAFA-3	TAFA3 FAM19A3	Homo sapiens (Human)	133	FUNCTION: Plays a role in the regulation of microglia polarization. {ECO:0000250|UniProtKB:Q7TPG6}.		negative regulation of microglial cell activation [GO:1903979]; neuroblast differentiation [GO:0014016]; positive regulation of microglial cell activation [GO:1903980]; regulation of neuroblast proliferation [GO:1902692]	extracellular space [GO:0005615]	receptor ligand activity [GO:0048018]	extracellular space [GO:0005615]; receptor ligand activity [GO:0048018]; negative regulation of microglial cell activation [GO:1903979]; neuroblast differentiation [GO:0014016]; positive regulation of microglial cell activation [GO:1903980]; regulation of neuroblast proliferation [GO:1902692]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15028294, ECO:0000269|PubMed:25595455}.
Q7Z5A9	reviewed	TAFA1_HUMAN	Chemokine-like protein TAFA-1	TAFA1 FAM19A1	Homo sapiens (Human)	133	FUNCTION: Regulatory factor which is ligand for CMKLR2 and is involved in the modulation of neural stem-cell proliferation and differentiation. {ECO:0000250|UniProtKB:Q7TPG8}.		neuroblast differentiation [GO:0014016]; regulation of neuroblast proliferation [GO:1902692]; regulation of signaling receptor activity [GO:0010469]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]	receptor ligand activity [GO:0048018]	endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; receptor ligand activity [GO:0048018]; neuroblast differentiation [GO:0014016]; regulation of neuroblast proliferation [GO:1902692]; regulation of signaling receptor activity [GO:0010469]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15028294}.
Q7Z5J8	reviewed	ANKAR_HUMAN	Ankyrin and armadillo repeat-containing protein	ANKAR	Homo sapiens (Human)	1434				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q7Z5L0	reviewed	VMO1_HUMAN	Vitelline membrane outer layer protein 1 homolog	VMO1 UNQ6350/PRO21055	Homo sapiens (Human)	202				extracellular exosome [GO:0070062]; extracellular space [GO:0005615]		extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q7Z5L3	reviewed	C1QL2_HUMAN	Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10)	C1QL2 CTRP10	Homo sapiens (Human)	287	FUNCTION: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). {ECO:0000250}.		neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; regulation of synapse maturation [GO:0090128]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; collagen trimer [GO:0005581]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synaptic cleft [GO:0043083]	identical protein binding [GO:0042802]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; collagen trimer [GO:0005581]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synaptic cleft [GO:0043083]; identical protein binding [GO:0042802]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; regulation of synapse maturation [GO:0090128]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q7Z5L4	reviewed	SPT19_HUMAN	Spermatogenesis-associated protein 19, mitochondrial (Spermatogenic cell-specific gene 1 protein) (Spergen-1)	SPATA19 SPERGEN1	Homo sapiens (Human)	167	FUNCTION: Essential for sperm motility and male fertility (By similarity). Plays an important role in sperm motility by regulating the organization and function of the mitochondria and is also required for correct sperm midpiece assembly (By similarity). {ECO:0000250|UniProtKB:Q9DAQ9}.		cell differentiation [GO:0030154]; sperm mitochondrion organization [GO:0030382]; spermatogenesis [GO:0007283]	mitochondrial outer membrane [GO:0005741]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]		mitochondrial outer membrane [GO:0005741]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; cell differentiation [GO:0030154]; sperm mitochondrion organization [GO:0030382]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9DAQ9}. Mitochondrion {ECO:0000250|UniProtKB:Q9DAQ9}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9DAQ9}. Note=Localizes to the midpiece of the sperm flagellum. {ECO:0000250|UniProtKB:Q9DAQ9}.
Q7Z5M5	reviewed	TMC3_HUMAN	Transmembrane channel-like protein 3	TMC3	Homo sapiens (Human)	1100	FUNCTION: Probable ion channel. {ECO:0000250}.			plasma membrane [GO:0005886]	mechanosensitive monoatomic ion channel activity [GO:0008381]	plasma membrane [GO:0005886]; mechanosensitive monoatomic ion channel activity [GO:0008381]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q7Z5S9	reviewed	TM144_HUMAN	Transmembrane protein 144	TMEM144	Homo sapiens (Human)	345				membrane [GO:0016020]	carbohydrate transmembrane transporter activity [GO:0015144]	membrane [GO:0016020]; carbohydrate transmembrane transporter activity [GO:0015144]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q7Z5Y7	reviewed	KCD20_HUMAN	BTB/POZ domain-containing protein KCTD20 (Potassium channel tetramerization domain containing 20)	KCTD20 C6orf69	Homo sapiens (Human)	419	FUNCTION: Promotes the phosphorylation of AKT family members. {ECO:0000250|UniProtKB:Q8CDD8}.		positive regulation of phosphorylation [GO:0042327]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; positive regulation of phosphorylation [GO:0042327]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8CDD8}. Note=Colocalizes with BTBD10 in filamentous structures. {ECO:0000250|UniProtKB:Q8CDD8}.
Q7Z6M2	reviewed	FBX33_HUMAN	F-box only protein 33	FBXO33 FBX33	Homo sapiens (Human)	555	FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity). {ECO:0000250}.		positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SCF ubiquitin ligase complex [GO:0019005]		SCF ubiquitin ligase complex [GO:0019005]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	
Q7Z6P3	reviewed	RAB44_HUMAN	Ras-related protein Rab-44	RAB44	Homo sapiens (Human)	1021			histamine secretion by mast cell [GO:0002553]; histamine secretion mediated by IgE immunoglobulin [GO:0097279]; vesicle-mediated transport [GO:0016192]	azurophil granule membrane [GO:0035577]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	azurophil granule membrane [GO:0035577]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; histamine secretion by mast cell [GO:0002553]; histamine secretion mediated by IgE immunoglobulin [GO:0097279]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Q7Z6W1	reviewed	TMCO2_HUMAN	Transmembrane and coiled-coil domain-containing protein 2	TMCO2	Homo sapiens (Human)	182				membrane [GO:0016020]; nucleus [GO:0005634]		membrane [GO:0016020]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q7Z6W7	reviewed	DNJB7_HUMAN	DnaJ homolog subfamily B member 7	DNAJB7 HSC3	Homo sapiens (Human)	309	FUNCTION: Probably acts as a co-chaperone. {ECO:0000250}.		chaperone-mediated protein folding [GO:0061077]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]	
Q7Z713	reviewed	ANR37_HUMAN	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp)	ANKRD37 LPR2BP	Homo sapiens (Human)	158				cytoplasm [GO:0005737]; cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15809689}. Cytoplasm {ECO:0000269|PubMed:15809689}.
Q7Z736	reviewed	PKHH3_HUMAN	Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3)	PLEKHH3	Homo sapiens (Human)	793			signal transduction [GO:0007165]	cytoskeleton [GO:0005856]; extracellular space [GO:0005615]		cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; signal transduction [GO:0007165]	
Q7Z7B8	reviewed	DB128_HUMAN	Beta-defensin 128 (Beta-defensin 28) (DEFB-28) (Defensin, beta 128)	DEFB128 DEFB28	Homo sapiens (Human)	93	FUNCTION: Has antibacterial activity. {ECO:0000305}.		defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q7Z7J9	reviewed	CK2N1_HUMAN	Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CaMKII inhibitory protein alpha) (CaMKIIN-alpha)	CAMK2N1	Homo sapiens (Human)	78	FUNCTION: Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (By similarity). {ECO:0000250|UniProtKB:Q6QWF9, ECO:0000250|UniProtKB:Q9JI15}.		long-term memory [GO:0007616]; positive regulation of inflammatory response [GO:0050729]	dendrite [GO:0030425]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	calcium-dependent protein kinase inhibitor activity [GO:0008427]; protein kinase binding [GO:0019901]	dendrite [GO:0030425]; postsynaptic density [GO:0014069]; synapse [GO:0045202]; calcium-dependent protein kinase inhibitor activity [GO:0008427]; protein kinase binding [GO:0019901]; long-term memory [GO:0007616]; positive regulation of inflammatory response [GO:0050729]	SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q6QWF9}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JI15}. Postsynaptic density {ECO:0000250|UniProtKB:Q6QWF9}.
Q7Z7K0	reviewed	COXM1_HUMAN	COX assembly mitochondrial protein homolog (Cmc1p)	CMC1 C3orf68	Homo sapiens (Human)	106	FUNCTION: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. {ECO:0000250}.			mitochondrion [GO:0005739]	metal ion binding [GO:0046872]	mitochondrion [GO:0005739]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18443040, ECO:0000269|PubMed:23676665}. Note=Colocalizes with MT-CO1.
Q7Z7K2	reviewed	ZN467_HUMAN	Zinc finger protein 467	ZNF467	Homo sapiens (Human)	595	FUNCTION: Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity). {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q86SI9	reviewed	CEI_HUMAN	Putative uncharacterized protein IRX2-DT (Coordinated expression to IRXA2 protein) (IRX2 divergent transcript) (Protein CEI)	IRX2-DT C5orf38 CEI	Homo sapiens (Human)	138		MISCELLANEOUS: According to PubMed:16515847, this gene is only represented in primates genome and it is highly conserved. Also found in bats (according to Ensembl).		extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86SM5	reviewed	MRGRG_HUMAN	Mas-related G-protein coupled receptor member G (G-protein coupled receptor 169)	MRGPRG GPR169 MRGG	Homo sapiens (Human)	289	FUNCTION: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). {ECO:0000250}.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q86SM8	reviewed	MRGRE_HUMAN	Mas-related G-protein coupled receptor member E (G-protein coupled receptor 167)	MRGPRE GPR167 MRGE	Homo sapiens (Human)	312	FUNCTION: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q86T20	reviewed	SIM29_HUMAN	Small integral membrane protein 29 (Protein LBH)	SMIM29 C6orf1 LBH	Homo sapiens (Human)	102				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q86T29	reviewed	ZN605_HUMAN	Zinc finger protein 605	ZNF605	Homo sapiens (Human)	641	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86T75	reviewed	NBPFB_HUMAN	Neuroblastoma breakpoint family member 11 (Neuroblastoma breakpoint family member 24)	NBPF11 NBPF24	Homo sapiens (Human)	865		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q86TE4	reviewed	LUZP2_HUMAN	Leucine zipper protein 2	LUZP2 UNQ2566/PRO6246	Homo sapiens (Human)	346				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86UF2	reviewed	CTGE6_HUMAN	cTAGE family member 6 (Protein cTAGE-6)	CTAGE6 CTAGE6P	Homo sapiens (Human)	777			endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q86UV7	reviewed	TRI73_HUMAN	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B)	TRIM73 TRIM50B	Homo sapiens (Human)	250			protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]	
Q86V35	reviewed	CABP7_HUMAN	Calcium-binding protein 7 (CaBP7) (Calneuron II) (Calneuron-2)	CABP7 CALN2	Homo sapiens (Human)	215	FUNCTION: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. {ECO:0000250}.			perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	calcium ion binding [GO:0005509]	perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000305|PubMed:19338761}; Single-pass type IV membrane protein {ECO:0000305|PubMed:19338761}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19338761}. Cell membrane {ECO:0000305|PubMed:19338761}; Single-pass type IV membrane protein {ECO:0000305|PubMed:19338761}.
Q86V71	reviewed	ZN429_HUMAN	Zinc finger protein 429	ZNF429	Homo sapiens (Human)	674	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86V87	reviewed	FHI2B_HUMAN	FHF complex subunit HOOK-interacting protein 2B (FHIP2B) (Retinoic acid-induced protein 16)	FHIP2B FAM160B2 RAI16 FP13191	Homo sapiens (Human)	743	FUNCTION: Able to activate MAPK/ERK and TGFB signaling pathways (PubMed:22971576). May regulate the activity of genes involved in intestinal barrier function and immunoprotective inflammation (By similarity). May play a role in cell proliferation (PubMed:22971576). {ECO:0000250|UniProtKB:Q80YR2, ECO:0000269|PubMed:22971576}.						
Q86V88	reviewed	MGDP1_HUMAN	Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48)	MDP1	Homo sapiens (Human)	176	FUNCTION: Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. {ECO:0000250}.				acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725]	acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725]	
Q86VE3	reviewed	SATL1_HUMAN	Spermidine/spermine N(1)-acetyltransferase-like protein 1 (EC 2.3.1.-)	SATL1	Homo sapiens (Human)	695			spermidine acetylation [GO:0032918]		diamine N-acetyltransferase activity [GO:0004145]; spermidine binding [GO:0019809]	diamine N-acetyltransferase activity [GO:0004145]; spermidine binding [GO:0019809]; spermidine acetylation [GO:0032918]	
Q86VG3	reviewed	IFTAP_HUMAN	Intraflagellar transport-associated protein (Protein HEPIS)	IFTAP C11orf74 NWC	Homo sapiens (Human)	221	FUNCTION: Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. {ECO:0000269|PubMed:30476139}.		acrosome reaction [GO:0007340]; spermatogenesis [GO:0007283]	9+0 non-motile cilium [GO:0097731]; cytosol [GO:0005829]	intraciliary transport particle A binding [GO:0120160]	9+0 non-motile cilium [GO:0097731]; cytosol [GO:0005829]; intraciliary transport particle A binding [GO:0120160]; acrosome reaction [GO:0007340]; spermatogenesis [GO:0007283]	
Q86VH4	reviewed	LRRT4_HUMAN	Leucine-rich repeat transmembrane neuronal protein 4	LRRTM4 UNQ3075/PRO9907	Homo sapiens (Human)	590	FUNCTION: May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). {ECO:0000250}.			extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; postsynaptic membrane [GO:0045211]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; postsynaptic membrane [GO:0045211]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q86VR8	reviewed	FJX1_HUMAN	Four-jointed box protein 1 (Four-jointed protein homolog)	FJX1	Homo sapiens (Human)	437	FUNCTION: Acts as an inhibitor of dendrite extension and branching. {ECO:0000250}.		cell-cell signaling [GO:0007267]; retina layer formation [GO:0010842]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; cell-cell signaling [GO:0007267]; retina layer formation [GO:0010842]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q86VS3	reviewed	IQCH_HUMAN	IQ domain-containing protein H (Testis development protein NYD-SP5)	IQCH	Homo sapiens (Human)	1027	FUNCTION: May play a regulatory role in spermatogenesis. {ECO:0000269|PubMed:15897968}.						
Q86VU5	reviewed	CMTD1_HUMAN	Catechol O-methyltransferase domain-containing protein 1 (EC 2.1.1.-)	COMTD1 UNQ766/PRO1558	Homo sapiens (Human)	262	FUNCTION: Putative O-methyltransferase. {ECO:0000305}.		methylation [GO:0032259]	membrane [GO:0016020]	O-methyltransferase activity [GO:0008171]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	membrane [GO:0016020]; O-methyltransferase activity [GO:0008171]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; methylation [GO:0032259]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q86VY9	reviewed	T200A_HUMAN	Transmembrane protein 200A	TMEM200A KIAA1913 HBE61	Homo sapiens (Human)	491				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q86W25	reviewed	NAL13_HUMAN	NACHT, LRR and PYD domains-containing protein 13 (Nucleotide-binding oligomerization domain protein 14)	NLRP13 NALP13 NOD14	Homo sapiens (Human)	1043	FUNCTION: Involved in inflammation. {ECO:0000305}.		regulation of inflammatory response [GO:0050727]	cytoplasm [GO:0005737]	ATP binding [GO:0005524]	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; regulation of inflammatory response [GO:0050727]	
Q86W34	reviewed	AMZ2_HUMAN	Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2)	AMZ2 BM-014	Homo sapiens (Human)	360	FUNCTION: Probable zinc metalloprotease. {ECO:0000250|UniProtKB:Q8TXW1}.		proteolysis [GO:0006508]		metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]	metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; proteolysis [GO:0006508]	
Q86WR7	reviewed	PRSR2_HUMAN	Proline and serine-rich protein 2	PROSER2 C10orf47	Homo sapiens (Human)	435							
Q86WS4	reviewed	CL040_HUMAN	Uncharacterized protein C12orf40	C12orf40	Homo sapiens (Human)	652							
Q86WT1	reviewed	IT70A_HUMAN	Intraflagellar transport protein 70A (Tetratricopeptide repeat protein 30A) (TPR repeat protein 30A)	IFT70A TTC30A	Homo sapiens (Human)	665	FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. {ECO:0000250}.		intraciliary transport [GO:0042073]	axonemal microtubule [GO:0005879]; intraciliary transport particle B [GO:0030992]	intraciliary transport particle B binding [GO:0120170]	axonemal microtubule [GO:0005879]; intraciliary transport particle B [GO:0030992]; intraciliary transport particle B binding [GO:0120170]; intraciliary transport [GO:0042073]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
Q86WZ6	reviewed	ZN227_HUMAN	Zinc finger protein 227	ZNF227	Homo sapiens (Human)	799	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86X60	reviewed	FA72B_HUMAN	Protein FAM72B	FAM72B	Homo sapiens (Human)	149		MISCELLANEOUS: Highly homologous to GCUD2 but localized to a distinct locus.		cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]		cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]	
Q86XA9	reviewed	HTR5A_HUMAN	HEAT repeat-containing protein 5A	HEATR5A C14orf125 KIAA1316	Homo sapiens (Human)	2040			endocytosis [GO:0006897]; protein localization [GO:0008104]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; endocytic vesicle [GO:0030139]		cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endocytosis [GO:0006897]; protein localization [GO:0008104]; retrograde transport, endosome to Golgi [GO:0042147]	
Q86XD8	reviewed	ZFAN4_HUMAN	AN1-type zinc finger protein 4 (AN1-type zinc finger and ubiquitin domain-containing protein-like 1)	ZFAND4 ANUBL1	Homo sapiens (Human)	727					zinc ion binding [GO:0008270]	zinc ion binding [GO:0008270]	
Q86XE3	reviewed	MICU3_HUMAN	Calcium uptake protein 3, mitochondrial (EF-hand domain-containing family member A2)	MICU3 EFHA2	Homo sapiens (Human)	530	FUNCTION: May play a role in mitochondrial calcium uptake. {ECO:0000250}.	MISCELLANEOUS: Binds calcium. {ECO:0000305}.	calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]	mitochondrial inner membrane [GO:0005743]; uniplex complex [GO:1990246]	calcium ion binding [GO:0005509]	mitochondrial inner membrane [GO:0005743]; uniplex complex [GO:1990246]; calcium ion binding [GO:0005509]; calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q86XJ0	reviewed	CAHM3_HUMAN	Calcium homeostasis modulator protein 3 (Protein A)	CALHM3 FAM26A	Homo sapiens (Human)	344	FUNCTION: Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3-mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances. {ECO:0000250|UniProtKB:J3QMI4}.		ATP transport [GO:0015867]; protein heterooligomerization [GO:0051291]; response to stimulus [GO:0050896]; sensory perception of taste [GO:0050909]	basolateral plasma membrane [GO:0016323]	monoatomic cation channel activity [GO:0005261]; voltage-gated monoatomic ion channel activity [GO:0005244]	basolateral plasma membrane [GO:0016323]; monoatomic cation channel activity [GO:0005261]; voltage-gated monoatomic ion channel activity [GO:0005244]; ATP transport [GO:0015867]; protein heterooligomerization [GO:0051291]; response to stimulus [GO:0050896]; sensory perception of taste [GO:0050909]	SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:J3QMI4}; Multi-pass membrane protein {ECO:0000255}.
Q86XN6	reviewed	ZN761_HUMAN	Zinc finger protein 761	ZNF761 KIAA2033	Homo sapiens (Human)	746	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86XS5	reviewed	ANGL5_HUMAN	Angiopoietin-related protein 5 (Angiopoietin-like protein 5)	ANGPTL5 UNQ5795/PRO19600	Homo sapiens (Human)	388				collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]	signaling receptor binding [GO:0005102]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; signaling receptor binding [GO:0005102]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86XU0	reviewed	ZN677_HUMAN	Zinc finger protein 677	ZNF677	Homo sapiens (Human)	584	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q86XZ4	reviewed	SPAS2_HUMAN	Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr)	SPATS2 SCR59 SPATA10 Nbla00526	Homo sapiens (Human)	545				cytoplasm [GO:0005737]; cytosol [GO:0005829]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q86YB7	reviewed	ECHD2_HUMAN	Enoyl-CoA hydratase domain-containing protein 2, mitochondrial	ECHDC2	Homo sapiens (Human)	292			fatty acid beta-oxidation [GO:0006635]	mitochondrion [GO:0005739]	lyase activity [GO:0016829]	mitochondrion [GO:0005739]; lyase activity [GO:0016829]; fatty acid beta-oxidation [GO:0006635]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q86YQ2	reviewed	LATH_HUMAN	Putative BPIFA4P protein (BPI fold containing family A, member 4, pseudogene) (Breast cancer and salivary gland-expressed protein) (Putative latherin)	BPIFA4P BASE LATH	Homo sapiens (Human)	179	FUNCTION: Major protein in sweat, has surfactant properties. {ECO:0000250}.			extracellular region [GO:0005576]	lipid binding [GO:0008289]	extracellular region [GO:0005576]; lipid binding [GO:0008289]	SUBCELLULAR LOCATION: Secreted.
Q86YQ8	reviewed	CPNE8_HUMAN	Copine-8 (Copine VIII)	CPNE8	Homo sapiens (Human)	564	FUNCTION: Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. {ECO:0000250|UniProtKB:Q99829}.		cellular response to calcium ion [GO:0071277]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]; cellular response to calcium ion [GO:0071277]	
Q86YR6	reviewed	POTED_HUMAN	POTE ankyrin domain family member D (ANKRD26-like family B member 3) (Ankyrin repeat domain-containing protein 21) (Prostate, ovary, testis-expressed protein) (Protein POTE)	POTED A26B3 ANKRD21 POTE	Homo sapiens (Human)	584				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12475935, ECO:0000269|PubMed:15276201}; Peripheral membrane protein {ECO:0000269|PubMed:12475935, ECO:0000269|PubMed:15276201}.
Q8IUA0	reviewed	WFDC8_HUMAN	WAP four-disulfide core domain protein 8 (Putative protease inhibitor WAP8)	WFDC8 C20orf170 WAP8	Homo sapiens (Human)	241				extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8IUB2	reviewed	WFDC3_HUMAN	WAP four-disulfide core domain protein 3 (Putative protease inhibitor WAP14)	WFDC3 WAP14	Homo sapiens (Human)	231			antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8IUB3	reviewed	WF10B_HUMAN	Protein WFDC10B	WFDC10B WAP12	Homo sapiens (Human)	73			antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8IUB5	reviewed	WFD13_HUMAN	WAP four-disulfide core domain protein 13	WFDC13 C20orf138 WAP13	Homo sapiens (Human)	93	FUNCTION: Putative acid-stable proteinase inhibitor. {ECO:0000250}.		antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8IUF1	reviewed	ZNG1B_HUMAN	Zinc-regulated GTPase metalloprotein activator 1B (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 2) (COBW domain-containing protein 2)	ZNG1B CBWD2	Homo sapiens (Human)	395	FUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1B to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}.			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VEH6}.
Q8IUH2	reviewed	CREG2_HUMAN	Protein CREG2 (Cellular repressor of E1A-stimulated genes 2)	CREG2	Homo sapiens (Human)	290				endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]		endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12408961}.
Q8IUK8	reviewed	CBLN2_HUMAN	Cerebellin-2	CBLN2 UNQ1892/PRO4338	Homo sapiens (Human)	224	FUNCTION: Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (By similarity). {ECO:0000250|UniProtKB:Q8BGU2}.		maintenance of synapse structure [GO:0099558]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; spontaneous synaptic transmission [GO:0098814]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]	extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; synapse [GO:0045202]		extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; synapse [GO:0045202]; maintenance of synapse structure [GO:0099558]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; spontaneous synaptic transmission [GO:0098814]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8BGU2}.
Q8IUL8	reviewed	CILP2_HUMAN	Cartilage intermediate layer protein 2 (CILP-2) [Cleaved into: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2]	CILP2	Homo sapiens (Human)	1156	FUNCTION: May play a role in cartilage scaffolding. {ECO:0000250|UniProtKB:O75339}.			extracellular exosome [GO:0070062]; extracellular space [GO:0005615]		extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:21880736}.
Q8IUS5	reviewed	EPHX4_HUMAN	Epoxide hydrolase 4 (EC 3.3.-.-) (Abhydrolase domain-containing protein 7) (Epoxide hydrolase-related protein)	EPHX4 ABHD7 EH4 EPHXRP	Homo sapiens (Human)	362				membrane [GO:0016020]	hydrolase activity [GO:0016787]	membrane [GO:0016020]; hydrolase activity [GO:0016787]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8IV03	reviewed	LUR1L_HUMAN	Leucine rich adaptor protein 1-like	LURAP1L C9orf150 HYST0841	Homo sapiens (Human)	228			positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of signal transduction [GO:0009966]			positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of signal transduction [GO:0009966]	
Q8IV33	reviewed	K0825_HUMAN	Uncharacterized protein KIAA0825	KIAA0825 C5orf36	Homo sapiens (Human)	1275							
Q8IV38	reviewed	ANKY2_HUMAN	Ankyrin repeat and MYND domain-containing protein 2	ANKMY2	Homo sapiens (Human)	441	FUNCTION: May be involved in the trafficking of signaling proteins to the cilia. {ECO:0000250}.			cilium [GO:0005929]	enzyme binding [GO:0019899]; metal ion binding [GO:0046872]	cilium [GO:0005929]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
Q8IV42	reviewed	PSTK_HUMAN	L-seryl-tRNA(Sec) kinase (EC 2.7.1.164) (O-phosphoseryl-tRNA(Sec) kinase)	PSTK C10orf89	Homo sapiens (Human)	348	FUNCTION: Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis. {ECO:0000250}.		phosphorylation [GO:0016310]; translation [GO:0006412]		ATP binding [GO:0005524]; kinase activity [GO:0016301]; L-seryl-tRNA(Sec) kinase activity [GO:0043915]; tRNA binding [GO:0000049]	ATP binding [GO:0005524]; kinase activity [GO:0016301]; L-seryl-tRNA(Sec) kinase activity [GO:0043915]; tRNA binding [GO:0000049]; phosphorylation [GO:0016310]; translation [GO:0006412]	
Q8IV50	reviewed	LYSM2_HUMAN	LysM and putative peptidoglycan-binding domain-containing protein 2	LYSMD2	Homo sapiens (Human)	215							
Q8IVA1	reviewed	PCP2_HUMAN	Purkinje cell protein 2 homolog	PCP2	Homo sapiens (Human)	136	FUNCTION: May function as a cell-type specific modulator for G protein-mediated cell signaling. {ECO:0000250}.				guanyl-nucleotide exchange factor activity [GO:0005085]	guanyl-nucleotide exchange factor activity [GO:0005085]	
Q8IVC4	reviewed	ZN584_HUMAN	Zinc finger protein 584	ZNF584	Homo sapiens (Human)	421	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IVF6	reviewed	AN18A_HUMAN	Ankyrin repeat domain-containing protein 18A	ANKRD18A KIAA2015	Homo sapiens (Human)	992							
Q8IVN3	reviewed	MSTN1_HUMAN	Musculoskeletal embryonic nuclear protein 1	MUSTN1	Homo sapiens (Human)	82	FUNCTION: May be involved in the development and regeneration of the musculoskeletal system. {ECO:0000250}.		chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of gene expression [GO:0010628]; positive regulation of proteoglycan biosynthetic process [GO:1902730]; tissue regeneration [GO:0042246]	nucleus [GO:0005634]		nucleus [GO:0005634]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of gene expression [GO:0010628]; positive regulation of proteoglycan biosynthetic process [GO:1902730]; tissue regeneration [GO:0042246]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8IVN8	reviewed	SBSPO_HUMAN	Somatomedin-B and thrombospondin type-1 domain-containing protein (RPE-spondin)	SBSPON C8orf84 RPESP	Homo sapiens (Human)	264				collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]		collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}.
Q8IVU1	reviewed	IGDC3_HUMAN	Immunoglobulin superfamily DCC subclass member 3 (Putative neuronal cell adhesion molecule)	IGDCC3 PUNC	Homo sapiens (Human)	814			cell-cell adhesion [GO:0098609]; neuromuscular process controlling balance [GO:0050885]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cell-cell adhesion [GO:0098609]; neuromuscular process controlling balance [GO:0050885]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q8IVV8	reviewed	NKAI4_HUMAN	Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4) (Protein FAM77A)	NKAIN4 C20orf58 FAM77A	Homo sapiens (Human)	208			regulation of sodium ion transport [GO:0002028]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; regulation of sodium ion transport [GO:0002028]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8IVY1	reviewed	CA210_HUMAN	Type III endosome membrane protein TEMP (TEMP)	C1orf210	Homo sapiens (Human)	113	FUNCTION: May be involved in membrane trafficking between endosomes and plasma membrane.			early endosome [GO:0005769]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]		early endosome [GO:0005769]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}. Early endosome {ECO:0000250|UniProtKB:Q9CQM1}. Recycling endosome {ECO:0000250|UniProtKB:Q9CQM1}. Cell membrane {ECO:0000250|UniProtKB:Q9CQM1}. Note=Also localizes to tubular endosome structures. {ECO:0000250|UniProtKB:Q9CQM1}.
Q8IW50	reviewed	F219A_HUMAN	Protein FAM219A	FAM219A C9orf25	Homo sapiens (Human)	185							
Q8IW70	reviewed	T151B_HUMAN	Transmembrane protein 151B (Transmembrane protein 193)	TMEM151B C6orf137 TMEM193	Homo sapiens (Human)	566				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8IW92	reviewed	GLBL2_HUMAN	Beta-galactosidase-1-like protein 2 (EC 3.2.1.-)	GLB1L2 MSTP014 UNQ210/PRO236	Homo sapiens (Human)	636			carbohydrate metabolic process [GO:0005975]	extracellular region [GO:0005576]; lysosome [GO:0005764]; vacuole [GO:0005773]	beta-galactosidase activity [GO:0004565]	extracellular region [GO:0005576]; lysosome [GO:0005764]; vacuole [GO:0005773]; beta-galactosidase activity [GO:0004565]; carbohydrate metabolic process [GO:0005975]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8IWB4	reviewed	S31A7_HUMAN	Spermatogenesis-associated protein 31A7 (Protein FAM75A7)	SPATA31A7 FAM75A4 FAM75A7 SPATA31A4	Homo sapiens (Human)	1347	FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8IX94	reviewed	CTGE4_HUMAN	cTAGE family member 4 (Protein cTAGE-4)	CTAGE4	Homo sapiens (Human)	777	FUNCTION: Tumor-associated antigen.	MISCELLANEOUS: Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL). Also found in colorectal and breast carcinomas, head and neck squamous cell carcinomas and melanoma.	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8IXE1	reviewed	OR4N5_HUMAN	Olfactory receptor 4N5 (Olfactory receptor OR14-33)	OR4N5	Homo sapiens (Human)	308	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8IXF9	reviewed	AQ12A_HUMAN	Aquaporin-12A (AQP-12)	AQP12A AQP12 AQPX2	Homo sapiens (Human)	295	FUNCTION: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. {ECO:0000250}.			cytoplasm [GO:0005737]; membrane [GO:0016020]	channel activity [GO:0015267]; water channel activity [GO:0015250]	cytoplasm [GO:0005737]; membrane [GO:0016020]; channel activity [GO:0015267]; water channel activity [GO:0015250]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8IXQ4	reviewed	GPAM1_HUMAN	GPALPP motifs-containing protein 1 (Lipopolysaccharide-specific response protein 7)	GPALPP1 KIAA1704 LSR7 AD029	Homo sapiens (Human)	340							
Q8IXT5	reviewed	RB12B_HUMAN	RNA-binding protein 12B (RNA-binding motif protein 12B)	RBM12B	Homo sapiens (Human)	1001			regulation of RNA splicing [GO:0043484]	nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; RNA binding [GO:0003723]; regulation of RNA splicing [GO:0043484]	
Q8IXU6	reviewed	S35F2_HUMAN	Solute carrier family 35 member F2	SLC35F2	Homo sapiens (Human)	374	FUNCTION: Putative solute transporter. {ECO:0000305}.			membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8IXX5	reviewed	T183A_HUMAN	Transmembrane protein 183A	TMEM183A C1orf37	Homo sapiens (Human)	376			regulation of protein stability [GO:0031647]	membrane [GO:0016020]; SCF ubiquitin ligase complex [GO:0019005]		membrane [GO:0016020]; SCF ubiquitin ligase complex [GO:0019005]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8IY50	reviewed	S35F3_HUMAN	Solute carrier family 35 member F3 (Thiamine transporter SLC35F3)	SLC35F3	Homo sapiens (Human)	421	FUNCTION: Mediates thiamine transport. {ECO:0000305|PubMed:24509276}.		thiamine transport [GO:0015888]	membrane [GO:0016020]		membrane [GO:0016020]; thiamine transport [GO:0015888]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q8IY51	reviewed	TIGD4_HUMAN	Tigger transposable element-derived protein 4	TIGD4	Homo sapiens (Human)	512				nucleus [GO:0005634]	DNA binding [GO:0003677]	nucleus [GO:0005634]; DNA binding [GO:0003677]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IY85	reviewed	EFC13_HUMAN	EF-hand calcium-binding domain-containing protein 13	EFCAB13 C17orf57	Homo sapiens (Human)	973							
Q8IYA7	reviewed	MKX_HUMAN	Homeobox protein Mohawk	MKX C10orf48 IRXL1	Homo sapiens (Human)	352	FUNCTION: May act as a morphogenetic regulator of cell adhesion. {ECO:0000250}.		cell development [GO:0048468]; muscle organ development [GO:0007517]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell development [GO:0048468]; muscle organ development [GO:0007517]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IYB9	reviewed	ZN595_HUMAN	Zinc finger protein 595	ZNF595	Homo sapiens (Human)	648	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IYK2	reviewed	TEKL1_HUMAN	Tektin-like protein 1 (Coiled-coil domain-containing protein 105)	TEKTL1 CCDC105	Homo sapiens (Human)	499				extracellular exosome [GO:0070062]		extracellular exosome [GO:0070062]	
Q8IYL3	reviewed	CA174_HUMAN	UPF0688 protein C1orf174	C1orf174	Homo sapiens (Human)	243				nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22361696}.
Q8IYM0	reviewed	F186B_HUMAN	Protein FAM186B	FAM186B C12orf25	Homo sapiens (Human)	893				protein-containing complex [GO:0032991]		protein-containing complex [GO:0032991]	
Q8IYN0	reviewed	ZN100_HUMAN	Zinc finger protein 100	ZNF100	Homo sapiens (Human)	542	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IYP2	reviewed	PRS58_HUMAN	Serine protease 58 (EC 3.4.21.4) (Trypsin-X3)	PRSS58 TRY1 TRYX3 UNQ2540/PRO6090	Homo sapiens (Human)	241			proteolysis [GO:0006508]	extracellular region [GO:0005576]; secretory granule [GO:0030141]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8IYS2	reviewed	K2013_HUMAN	Uncharacterized protein KIAA2013	KIAA2013	Homo sapiens (Human)	634				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8IYS8	reviewed	BD1L2_HUMAN	Biorientation of chromosomes in cell division protein 1-like 2 (Biorientation of chromosomes in cell division protein 1 pseudogene) (Protein FAM44C)	BOD1L2 BOD1P FAM44C	Homo sapiens (Human)	172	FUNCTION: May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. {ECO:0000250|UniProtKB:Q96IK1}.		cell cycle [GO:0007049]; cell division [GO:0051301]	cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule organizing center [GO:0005815]		cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule organizing center [GO:0005815]; cell cycle [GO:0007049]; cell division [GO:0051301]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96IK1}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q96IK1}.
Q8IYW4	reviewed	ENTD1_HUMAN	ENTH domain-containing protein 1 (Epsin-2B)	ENTHD1	Homo sapiens (Human)	607			endocytosis [GO:0006897]	clathrin vesicle coat [GO:0030125]; endosome [GO:0005768]; plasma membrane [GO:0005886]	clathrin binding [GO:0030276]; phospholipid binding [GO:0005543]	clathrin vesicle coat [GO:0030125]; endosome [GO:0005768]; plasma membrane [GO:0005886]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543]; endocytosis [GO:0006897]	
Q8IZ02	reviewed	LRC34_HUMAN	Leucine-rich repeat-containing protein 34	LRRC34	Homo sapiens (Human)	464	FUNCTION: Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. {ECO:0000250|UniProtKB:Q9DAM1}.		cell differentiation [GO:0030154]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]		cytoplasm [GO:0005737]; nucleolus [GO:0005730]; cell differentiation [GO:0030154]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9DAM1}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9DAM1}. Cytoplasm {ECO:0000250|UniProtKB:Q9DAM1}. Note=As stem cells differentiate, translocates from the nucleolus to the nucleus and then to the cytoplasm. Colocalizes with NPM1 and NCL in the nucleolus. {ECO:0000250|UniProtKB:Q9DAM1}.
Q8IZ13	reviewed	F200C_HUMAN	Protein FAM200C (Protein ZBED8) (Transposon-derived Buster3 transposase-like protein) (Zinc finger BED domain-containing protein 8)	FAM200C Buster3 C5orf54 ZBED8	Homo sapiens (Human)	594		MISCELLANEOUS: May be derived from an ancient transposon that has lost its ability to translocate. Exhibits a close evolutionary relationship with ZBED5, but does not contain any zinc finger. {ECO:0000269|PubMed:23533661}.		nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	
Q8IZ16	reviewed	SACDR_HUMAN	Sperm acrosome developmental regulator	SPACDR C7orf61	Homo sapiens (Human)	206	FUNCTION: May play a role in acrosome formation and nucleus shaping during spermiogenesis. {ECO:0000269|PubMed:31985809}.		spermatid development [GO:0007286]	acrosomal vesicle [GO:0001669]; nucleus [GO:0005634]		acrosomal vesicle [GO:0001669]; nucleus [GO:0005634]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:31985809}. Note=Detected in acrosome of round spermatids and spermatozoa. {ECO:0000269|PubMed:31985809}.
Q8IZ40	reviewed	RCOR2_HUMAN	REST corepressor 2	RCOR2	Homo sapiens (Human)	523	FUNCTION: May act as a component of a corepressor complex that represses transcription. {ECO:0000305}.		negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	histone deacetylase complex [GO:0000118]; transcription regulator complex [GO:0005667]	enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714]	histone deacetylase complex [GO:0000118]; transcription regulator complex [GO:0005667]; enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.
Q8IZ81	reviewed	ELMD2_HUMAN	ELMO domain-containing protein 2	ELMOD2	Homo sapiens (Human)	293	FUNCTION: Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses. {ECO:0000269|PubMed:17452337, ECO:0000269|PubMed:19966137}.		defense response to virus [GO:0051607]; regulation of defense response to virus [GO:0050688]	membrane [GO:0016020]	GTPase activator activity [GO:0005096]	membrane [GO:0016020]; GTPase activator activity [GO:0005096]; defense response to virus [GO:0051607]; regulation of defense response to virus [GO:0050688]	
Q8IZD0	reviewed	SAM14_HUMAN	Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14)	SAMD14	Homo sapiens (Human)	417			actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; neuron projection development [GO:0031175]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; postsynaptic density [GO:0014069]	actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; postsynaptic density [GO:0014069]; actin filament binding [GO:0051015]; actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; neuron projection development [GO:0031175]	
Q8IZJ6	reviewed	TDH_HUMAN	Inactive L-threonine 3-dehydrogenase, mitochondrial (Short chain dehydrogenase/reductase family 14E member 1 pseudogene)	TDH SDR14E1P	Homo sapiens (Human)	230				mitochondrial inner membrane [GO:0005743]		mitochondrial inner membrane [GO:0005743]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8MIR0}.
Q8IZM8	reviewed	ZN654_HUMAN	Zinc finger protein 654 (Melanoma-associated antigen)	ZNF654	Homo sapiens (Human)	1128	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8IZN7	reviewed	D107A_HUMAN	Beta-defensin 107 (Beta-defensin 7) (BD-7) (DEFB-7) (Defensin, beta 107)	DEFB107A DEFB107 DEFB7; DEFB107B	Homo sapiens (Human)	70	FUNCTION: Has antibacterial activity. {ECO:0000305}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular region [GO:0005576]	lipid binding [GO:0008289]	extracellular region [GO:0005576]; lipid binding [GO:0008289]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted.
Q8IZP2	reviewed	ST134_HUMAN	Putative protein FAM10A4 (Suppression of tumorigenicity 13 pseudogene 4)	ST13P4 FAM10A4	Homo sapiens (Human)	240				cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	protein dimerization activity [GO:0046983]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; protein dimerization activity [GO:0046983]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8IZY5	reviewed	BLID_HUMAN	BH3-like motif-containing cell death inducer (Breast cancer cell protein 2)	BLID BRCC2	Homo sapiens (Human)	108	FUNCTION: Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death. {ECO:0000269|PubMed:15069058}.		apoptotic process [GO:0006915]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]	cytosol [GO:0005829]; mitochondrion [GO:0005739]		cytosol [GO:0005829]; mitochondrion [GO:0005739]; apoptotic process [GO:0006915]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15069058}. Mitochondrion {ECO:0000269|PubMed:15069058}. Note=Lower abundance in mitochondrion than in cytoplasm.
Q8N0U6	reviewed	CF218_HUMAN	Putative uncharacterized protein encoded by LINC00518	LINC00518 C6orf218	Homo sapiens (Human)	118							
Q8N0V4	reviewed	LGI2_HUMAN	Leucine-rich repeat LGI family member 2 (LGI1-like protein 2) (Leucine-rich glioma-inactivated protein 2)	LGI2 KIAA1916 LGIL2	Homo sapiens (Human)	545	FUNCTION: Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells. {ECO:0000250|UniProtKB:Q8K4Z0}.		inhibitory synapse assembly [GO:1904862]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; inhibitory synapse assembly [GO:1904862]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N0Y3	reviewed	OR4N4_HUMAN	Olfactory receptor 4N4 (Olfactory receptor OR15-1) (Olfactory receptor OR15-5)	OR4N4	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8N0Y5	reviewed	OR8I2_HUMAN	Olfactory receptor 8I2 (Olfactory receptor OR11-170)	OR8I2	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8N0Z2	reviewed	ABRA_HUMAN	Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS)	ABRA	Homo sapiens (Human)	381	FUNCTION: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. {ECO:0000250|UniProtKB:Q8BUZ1}.		positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; transcription by RNA polymerase II [GO:0006366]	actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]; sarcomere [GO:0030017]	actin binding [GO:0003779]	actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]; sarcomere [GO:0030017]; actin binding [GO:0003779]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; transcription by RNA polymerase II [GO:0006366]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines. {ECO:0000250}.
Q8N0Z9	reviewed	VSI10_HUMAN	V-set and immunoglobulin domain-containing protein 10	VSIG10	Homo sapiens (Human)	540			cell-cell adhesion [GO:0098609]	cell-cell junction [GO:0005911]; membrane [GO:0016020]	cell adhesion molecule binding [GO:0050839]	cell-cell junction [GO:0005911]; membrane [GO:0016020]; cell adhesion molecule binding [GO:0050839]; cell-cell adhesion [GO:0098609]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8N127	reviewed	O5AS1_HUMAN	Olfactory receptor 5AS1 (Olfactory receptor OR11-168)	OR5AS1	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8N129	reviewed	CNPY4_HUMAN	Protein canopy homolog 4	CNPY4 PSEC0237 UNQ1909/PRO4354	Homo sapiens (Human)	248	FUNCTION: Plays a role in the regulation of the cell surface expression of TLR4. {ECO:0000269|PubMed:16338228}.		positive regulation of protein localization to plasma membrane [GO:1903078]	extracellular region [GO:0005576]	signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; signaling receptor binding [GO:0005102]; positive regulation of protein localization to plasma membrane [GO:1903078]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N141	reviewed	ZFP82_HUMAN	Zinc finger protein 82 homolog (Zfp-82) (Zinc finger protein 545)	ZFP82 KIAA1948 ZNF545	Homo sapiens (Human)	532	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N146	reviewed	OR8H3_HUMAN	Olfactory receptor 8H3 (Olfactory receptor OR11-172)	OR8H3	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8N148	reviewed	OR6V1_HUMAN	Olfactory receptor 6V1 (Olfactory receptor OR7-3)	OR6V1	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8N162	reviewed	OR8H2_HUMAN	Olfactory receptor 8H2 (Olfactory receptor OR11-171)	OR8H2	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8N1A6	reviewed	CD033_HUMAN	UPF0462 protein C4orf33	C4orf33	Homo sapiens (Human)	199							
Q8N1E2	reviewed	LYG1_HUMAN	Lysozyme g-like protein 1 (EC 3.2.1.-)	LYG1 UNQ1939/PRO4422	Homo sapiens (Human)	194			defense response to Gram-positive bacterium [GO:0050830]; peptidoglycan catabolic process [GO:0009253]	extracellular region [GO:0005576]	lysozyme activity [GO:0003796]	extracellular region [GO:0005576]; lysozyme activity [GO:0003796]; defense response to Gram-positive bacterium [GO:0050830]; peptidoglycan catabolic process [GO:0009253]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N1L4	reviewed	CP4Z2_HUMAN	Putative inactive cytochrome P450 family member 4Z2	CYP4Z2P	Homo sapiens (Human)	340				membrane [GO:0016020]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	membrane [GO:0016020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q8N1N0	reviewed	CLC4F_HUMAN	C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13)	CLEC4F CLECSF13	Homo sapiens (Human)	589	FUNCTION: Receptor with an affinity for galactose and fucose. Could be involved in endocytosis (By similarity). {ECO:0000250}.		endocytosis [GO:0006897]	external side of plasma membrane [GO:0009897]	carbohydrate binding [GO:0030246]	external side of plasma membrane [GO:0009897]; carbohydrate binding [GO:0030246]; endocytosis [GO:0006897]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Q8N1W2	reviewed	ZN710_HUMAN	Zinc finger protein 710	ZNF710	Homo sapiens (Human)	664	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N228	reviewed	SCML4_HUMAN	Sex comb on midleg-like protein 4	SCML4	Homo sapiens (Human)	414	FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}.		negative regulation of DNA-templated transcription [GO:0045892]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; negative regulation of DNA-templated transcription [GO:0045892]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N283	reviewed	ANR35_HUMAN	Ankyrin repeat domain-containing protein 35	ANKRD35	Homo sapiens (Human)	1001					actin binding [GO:0003779]	actin binding [GO:0003779]	
Q8N2I2	reviewed	ZN619_HUMAN	Zinc finger protein 619	ZNF619	Homo sapiens (Human)	560	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N2X6	reviewed	EXAS1_HUMAN	Uncharacterized protein EXOC3-AS1 (EXOC3 antisense RNA 1) (EXOC3 antisense gene protein 1)	EXOC3-AS1 C5orf55	Homo sapiens (Human)	119				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N309	reviewed	LRC43_HUMAN	Leucine-rich repeat-containing protein 43	LRRC43	Homo sapiens (Human)	656			axoneme assembly [GO:0035082]	axoneme [GO:0005930]	dynein complex binding [GO:0070840]	axoneme [GO:0005930]; dynein complex binding [GO:0070840]; axoneme assembly [GO:0035082]	
Q8N323	reviewed	NXPE1_HUMAN	NXPE family member 1 (Protein FAM55A)	NXPE1 FAM55A	Homo sapiens (Human)	547				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted.
Q8N328	reviewed	PGBD3_HUMAN	PiggyBac transposable element-derived protein 3	PGBD3	Homo sapiens (Human)	593	FUNCTION: Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF. {ECO:0000269|PubMed:22483866}.	MISCELLANEOUS: PGBD3 gene is located within ERCC6 intron 5. {ECO:0000269|PubMed:18369450}.		nucleus [GO:0005634]	sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; sequence-specific DNA binding [GO:0043565]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26218421}.
Q8N336	reviewed	ELMD1_HUMAN	ELMO domain-containing protein 1	ELMOD1	Homo sapiens (Human)	334	FUNCTION: Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. {ECO:0000269|PubMed:17452337}.				GTPase activator activity [GO:0005096]	GTPase activator activity [GO:0005096]	
Q8N349	reviewed	OR2LD_HUMAN	Olfactory receptor 2L13 (Olfactory receptor 2L14)	OR2L13 OR2L14	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8N3F9	reviewed	G137C_HUMAN	Integral membrane protein GPR137C (Transmembrane 7 superfamily member 1-like 2 protein)	GPR137C TM7SF1L2	Homo sapiens (Human)	429	FUNCTION: Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. {ECO:0000269|PubMed:31036939}.		positive regulation of TORC1 signaling [GO:1904263]	lysosomal membrane [GO:0005765]		lysosomal membrane [GO:0005765]; positive regulation of TORC1 signaling [GO:1904263]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:31036939}; Multi-pass membrane protein {ECO:0000255}.
Q8N3H0	reviewed	TAFA2_HUMAN	Chemokine-like protein TAFA-2	TAFA2 FAM19A2	Homo sapiens (Human)	131	FUNCTION: Has a role as neurotrophic factor involved in neuronal survival and neurobiological functions. {ECO:0000250|UniProtKB:Q7TPG7}.		memory [GO:0007613]; visual learning [GO:0008542]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]	receptor ligand activity [GO:0048018]	cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; receptor ligand activity [GO:0048018]; memory [GO:0007613]; visual learning [GO:0008542]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15028294}. Nucleus {ECO:0000250|UniProtKB:Q7TPG7}.
Q8N3R3	reviewed	TCAIM_HUMAN	T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1)	TCAIM C3orf23 TOAG1	Homo sapiens (Human)	496	FUNCTION: May regulate T-cell apoptosis. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		mitochondrion [GO:0005739]		mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
Q8N3S3	reviewed	PHTF2_HUMAN	Protein PHTF2	PHTF2	Homo sapiens (Human)	785				endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]		endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q8N3T6	reviewed	T132C_HUMAN	Transmembrane protein 132C	TMEM132C	Homo sapiens (Human)	1108				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8N3Z0	reviewed	PRS35_HUMAN	Inactive serine protease 35	PRSS35 C6orf158 UNQ522/PRO1057	Homo sapiens (Human)	413				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N3Z3	reviewed	GTPB8_HUMAN	GTP-binding protein 8	GTPBP8	Homo sapiens (Human)	284		MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		mitochondrion [GO:0005739]	GTP binding [GO:0005525]; metal ion binding [GO:0046872]	mitochondrion [GO:0005739]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]	
Q8N413	reviewed	S2545_HUMAN	Solute carrier family 25 member 45	SLC25A45	Homo sapiens (Human)	288				mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	transmembrane transporter activity [GO:0022857]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q8N431	reviewed	RGF1C_HUMAN	Ras-GEF domain-containing family member 1C	RASGEF1C	Homo sapiens (Human)	466	FUNCTION: Guanine nucleotide exchange factor (GEF). {ECO:0000250}.		Ras protein signal transduction [GO:0007265]	plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; Ras protein signal transduction [GO:0007265]	
Q8N434	reviewed	SVOPL_HUMAN	Putative transporter SVOPL (SV2-related protein-like) (SVOP-like protein)	SVOPL	Homo sapiens (Human)	492				membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N456	reviewed	LRC18_HUMAN	Leucine-rich repeat-containing protein 18	LRRC18 UNQ9338/PRO34010	Homo sapiens (Human)	261	FUNCTION: May be involved in the regulation of spermatogenesis and sperm maturation. {ECO:0000250}.		signal transduction [GO:0007165]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]		cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8N468	reviewed	MFD4A_HUMAN	Major facilitator superfamily domain-containing protein 4A (Major facilitator superfamily domain-containing protein 4)	MFSD4A MFSD4 UNQ3064/PRO9894	Homo sapiens (Human)	514				membrane [GO:0016020]	glucose transmembrane transporter activity [GO:0005355]	membrane [GO:0016020]; glucose transmembrane transporter activity [GO:0005355]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N4B4	reviewed	FBX39_HUMAN	F-box only protein 39	FBXO39 FBX39	Homo sapiens (Human)	442	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.		SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SCF ubiquitin ligase complex [GO:0019005]		SCF ubiquitin ligase complex [GO:0019005]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	
Q8N4F7	reviewed	RN175_HUMAN	RING finger protein 175	RNF175	Homo sapiens (Human)	328			ubiquitin-dependent ERAD pathway [GO:0030433]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-dependent ERAD pathway [GO:0030433]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N4H0	reviewed	SPA6L_HUMAN	Spermatogenesis associated 6-like protein	SPATA6L C9orf68	Homo sapiens (Human)	392		MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.	spermatogenesis [GO:0007283]	sperm connecting piece [GO:0097224]	myosin light chain binding [GO:0032027]	sperm connecting piece [GO:0097224]; myosin light chain binding [GO:0032027]; spermatogenesis [GO:0007283]	
Q8N4S0	reviewed	CCD82_HUMAN	Coiled-coil domain-containing protein 82	CCDC82 HT025	Homo sapiens (Human)	544				nucleus [GO:0005634]		nucleus [GO:0005634]	
Q8N4Z0	reviewed	RAB42_HUMAN	Ras-related protein Rab-42	RAB42	Homo sapiens (Human)	218				plasma membrane [GO:0005886]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P62820}; Lipid-anchor {ECO:0000250|UniProtKB:P62820}.
Q8N531	reviewed	FBXL6_HUMAN	F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6) (FBL6A)	FBXL6 FBL6	Homo sapiens (Human)	539	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.		proteolysis [GO:0006508]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SCF ubiquitin ligase complex [GO:0019005]	ubiquitin-protein transferase activity [GO:0004842]	SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; proteolysis [GO:0006508]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	
Q8N567	reviewed	ZCHC9_HUMAN	Zinc finger CCHC domain-containing protein 9	ZCCHC9	Homo sapiens (Human)	271	FUNCTION: May down-regulate transcription mediated by NF-kappa-B and the serum response element. {ECO:0000269|PubMed:18721783}.			nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:18721783}. Nucleus {ECO:0000269|PubMed:18721783}. Note=Expressed throughout the nucleus and concentrated mainly in the nucleolus. {ECO:0000269|PubMed:18721783}.
Q8N584	reviewed	TT39C_HUMAN	Tetratricopeptide repeat protein 39C (TPR repeat protein 39C)	TTC39C C18orf17	Homo sapiens (Human)	583			cilium assembly [GO:0060271]; otolith morphogenesis [GO:0032474]			cilium assembly [GO:0060271]; otolith morphogenesis [GO:0032474]	
Q8N587	reviewed	ZN561_HUMAN	Zinc finger protein 561	ZNF561	Homo sapiens (Human)	486	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N5C6	reviewed	SRBD1_HUMAN	S1 RNA-binding domain-containing protein 1	SRBD1	Homo sapiens (Human)	995			nucleobase-containing compound metabolic process [GO:0006139]; translation [GO:0006412]		mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735]	mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735]; nucleobase-containing compound metabolic process [GO:0006139]; translation [GO:0006412]	
Q8N5H3	reviewed	LRA25_HUMAN	Leucine repeat adapter protein 25	FAM89B Lrap25	Homo sapiens (Human)	189	FUNCTION: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. {ECO:0000250|UniProtKB:Q9QUI1}.		establishment of cell polarity [GO:0030010]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell migration [GO:0030335]	cytoplasm [GO:0005737]; lamellipodium [GO:0030027]	transcription corepressor binding [GO:0001222]	cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; transcription corepressor binding [GO:0001222]; establishment of cell polarity [GO:0030010]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell migration [GO:0030335]	SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000250|UniProtKB:Q9QUI1}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9QUI1}. Note=Co-localizes with CDC42BPA, CDC42BPB and LIMK1 in the lamellipodium. {ECO:0000250|UniProtKB:Q9QUI1}.
Q8N5I9	reviewed	NOPC1_HUMAN	NOP protein chaperone 1	NOPCHAP1 C12orf45	Homo sapiens (Human)	185	FUNCTION: Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2. {ECO:0000269|PubMed:33367824}.		box C/D snoRNP assembly [GO:0000492]	nucleus [GO:0005634]	box C/D snoRNP complex binding [GO:0062064]	nucleus [GO:0005634]; box C/D snoRNP complex binding [GO:0062064]; box C/D snoRNP assembly [GO:0000492]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:33367824}.
Q8N5J4	reviewed	SPIC_HUMAN	Transcription factor Spi-C	SPIC	Homo sapiens (Human)	248	FUNCTION: Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). {ECO:0000250}.		blastocyst development [GO:0001824]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; blastocyst development [GO:0001824]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N5T2	reviewed	TBC19_HUMAN	TBC1 domain family member 19	TBC1D19	Homo sapiens (Human)	526	FUNCTION: May act as a GTPase-activating protein for Rab family protein(s).				GTPase activator activity [GO:0005096]	GTPase activator activity [GO:0005096]	
Q8N5U1	reviewed	M4A15_HUMAN	Membrane-spanning 4-domains subfamily A member 15	MS4A15	Homo sapiens (Human)	240	FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex. {ECO:0000250}.		cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N5W9	reviewed	RFLB_HUMAN	Refilin-B (Regulator of filamin protein B) (RefilinB)	RFLNB	Homo sapiens (Human)	214	FUNCTION: Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. {ECO:0000250|UniProtKB:Q5SVD0}.		actin filament bundle organization [GO:0061572]; epithelial to mesenchymal transition [GO:0001837]; negative regulation of bone mineralization involved in bone maturation [GO:1900158]; negative regulation of chondrocyte development [GO:0061182]; skeletal system morphogenesis [GO:0048705]	actin filament bundle [GO:0032432]; cytoplasm [GO:0005737]	filamin binding [GO:0031005]	actin filament bundle [GO:0032432]; cytoplasm [GO:0005737]; filamin binding [GO:0031005]; actin filament bundle organization [GO:0061572]; epithelial to mesenchymal transition [GO:0001837]; negative regulation of bone mineralization involved in bone maturation [GO:1900158]; negative regulation of chondrocyte development [GO:0061182]; skeletal system morphogenesis [GO:0048705]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5SVD0}. Note=Colocalizes with FLNA along actin bundle-like structures. {ECO:0000250|UniProtKB:Q5SVD0}.
Q8N5X7	reviewed	IF4E3_HUMAN	Eukaryotic translation initiation factor 4E type 3 (eIF-4E type 3) (eIF-4E3) (eIF4E type 3) (eIF4E-3)	EIF4E3	Homo sapiens (Human)	224	FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; mRNA cap binding complex [GO:0005845]	RNA 7-methylguanosine cap binding [GO:0000340]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; mRNA cap binding complex [GO:0005845]; RNA 7-methylguanosine cap binding [GO:0000340]; translation initiation factor activity [GO:0003743]	
Q8N660	reviewed	NBPFF_HUMAN	Neuroblastoma breakpoint family member 15 (Neuroblastoma breakpoint family member 16)	NBPF15 NBPF16	Homo sapiens (Human)	670		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1. {ECO:0000303|PubMed:16079250}.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8N687	reviewed	DB125_HUMAN	Beta-defensin 125 (Beta-defensin 25) (DEFB-25) (Defensin, beta 125)	DEFB125 DEFB25	Homo sapiens (Human)	156	FUNCTION: Has antibacterial activity. {ECO:0000305}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N688	reviewed	DB123_HUMAN	Beta-defensin 123 (Beta-defensin 23) (DEFB-23) (Defensin, beta 123)	DEFB123 DEFB23 UNQ1963/PRO4485	Homo sapiens (Human)	67	FUNCTION: Has antibacterial activity. {ECO:0000305}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N6M5	reviewed	ALLC_HUMAN	Probable inactive allantoicase (Allantoate amidinohydrolase)	ALLC	Homo sapiens (Human)	391	FUNCTION: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals. {ECO:0000305|PubMed:12036579}.		allantoin catabolic process [GO:0000256]		allantoicase activity [GO:0004037]	allantoicase activity [GO:0004037]; allantoin catabolic process [GO:0000256]	
Q8N6M8	reviewed	IQCF1_HUMAN	IQ domain-containing protein F1	IQCF1	Homo sapiens (Human)	205	FUNCTION: Involved in sperm capacitation and acrosome reaction. {ECO:0000250|UniProtKB:Q9D9K8}.		positive regulation of acrosome reaction [GO:2000344]; positive regulation of flagellated sperm motility involved in capacitation [GO:0060474]	acrosomal vesicle [GO:0001669]	calmodulin binding [GO:0005516]	acrosomal vesicle [GO:0001669]; calmodulin binding [GO:0005516]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of flagellated sperm motility involved in capacitation [GO:0060474]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:25380116}.
Q8N6M9	reviewed	ZFN2A_HUMAN	AN1-type zinc finger protein 2A	ZFAND2A	Homo sapiens (Human)	145			cellular response to arsenic-containing substance [GO:0071243]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein targeting to ER [GO:0045047]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; proteasome complex [GO:0000502]	zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; zinc ion binding [GO:0008270]; cellular response to arsenic-containing substance [GO:0071243]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein targeting to ER [GO:0045047]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q8N6N3	reviewed	CA052_HUMAN	UPF0690 protein C1orf52 (BCL10-associated gene protein)	C1orf52 BAG GM117	Homo sapiens (Human)	182				nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; RNA binding [GO:0003723]	
Q8N6N6	reviewed	NATD1_HUMAN	Protein NATD1 (N-acetyltransferase domain-containing protein 1)	NATD1 C17orf103 GTLF3B	Homo sapiens (Human)	113							
Q8N6N7	reviewed	ACBD7_HUMAN	Acyl-CoA-binding domain-containing protein 7	ACBD7	Homo sapiens (Human)	88	FUNCTION: Binds medium- and long-chain acyl-CoA esters.		fatty acid metabolic process [GO:0006631]		fatty-acyl-CoA binding [GO:0000062]	fatty-acyl-CoA binding [GO:0000062]; fatty acid metabolic process [GO:0006631]	
Q8N6Q1	reviewed	TMC5A_HUMAN	Transmembrane and coiled-coil domain-containing protein 5A	TMCO5A TMCO5	Homo sapiens (Human)	288				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8N6V9	reviewed	TEX9_HUMAN	Testis-expressed protein 9	TEX9	Homo sapiens (Human)	391				centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]		centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26638075}.
Q8N6Y2	reviewed	LRC17_HUMAN	Leucine-rich repeat-containing protein 17 (p37NB)	LRRC17 P37NB UNQ3076/PRO9909	Homo sapiens (Human)	441	FUNCTION: Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity). {ECO:0000250}.		bone marrow development [GO:0048539]; negative regulation of osteoclast differentiation [GO:0045671]; ossification [GO:0001503]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; bone marrow development [GO:0048539]; negative regulation of osteoclast differentiation [GO:0045671]; ossification [GO:0001503]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
Q8N782	reviewed	ZN525_HUMAN	Zinc finger protein 525	ZNF525 KIAA1979	Homo sapiens (Human)	479	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N7C7	reviewed	RN148_HUMAN	RING finger protein 148	RNF148	Homo sapiens (Human)	305			ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; membrane [GO:0016020]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8N7F7	reviewed	UBL4B_HUMAN	Ubiquitin-like protein 4B	UBL4B	Homo sapiens (Human)	174		MISCELLANEOUS: May have arisen from retrotransposition of the X-linked UBL4A gene during mammalian evolution.	positive regulation of protein targeting to mitochondrion [GO:1903955]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; positive regulation of protein targeting to mitochondrion [GO:1903955]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8N7G0	reviewed	PO5F2_HUMAN	POU domain, class 5, transcription factor 2 (Sperm 1 POU domain transcription factor) (SPRM-1)	POU5F2 SPRM1	Homo sapiens (Human)	328	FUNCTION: Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity). {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00530}.
Q8N7M0	reviewed	DYLT5_HUMAN	Dynein light chain Tctex-type 5 (Tctex1 domain-containing protein 1)	DYNLT5 TCTEX1D1	Homo sapiens (Human)	179			microtubule-based movement [GO:0007018]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; dynein intermediate chain binding [GO:0045505]; microtubule-based movement [GO:0007018]	
Q8N7Q3	reviewed	ZN676_HUMAN	Zinc finger protein 676	ZNF676	Homo sapiens (Human)	588	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N7R0	reviewed	NANG2_HUMAN	Putative homeobox protein NANOG2	NANOGP1 NANOG2	Homo sapiens (Human)	232	FUNCTION: Probable transcriptional regulator.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q8N7R7	reviewed	CCYL1_HUMAN	Cyclin-Y-like protein 1	CCNYL1	Homo sapiens (Human)	359			regulation of canonical Wnt signaling pathway [GO:0060828]	plasma membrane [GO:0005886]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; protein kinase binding [GO:0019901]	plasma membrane [GO:0005886]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; protein kinase binding [GO:0019901]; regulation of canonical Wnt signaling pathway [GO:0060828]	
Q8N7S2	reviewed	DNJ5G_HUMAN	DnaJ homolog subfamily C member 5G (Cysteine string protein-gamma) (CSP-gamma)	DNAJC5G	Homo sapiens (Human)	189				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Q8N7Z5	reviewed	ANR31_HUMAN	Ankyrin repeat domain-containing protein 31	ANKRD31	Homo sapiens (Human)	1873	FUNCTION: Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes. {ECO:0000250|UniProtKB:A0A140LI88}.		homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break formation involved in reciprocal meiotic recombination [GO:0010780]; positive regulation of meiotic DNA double-strand break formation [GO:1903343]	chromatin [GO:0000785]; nucleus [GO:0005634]		chromatin [GO:0000785]; nucleus [GO:0005634]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break formation involved in reciprocal meiotic recombination [GO:0010780]; positive regulation of meiotic DNA double-strand break formation [GO:1903343]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A0A140LI88}. Chromosome {ECO:0000250|UniProtKB:A0A140LI88}. Note=Localizes on chromatin between preleptotene and early pachytene. Associates with the chromosome axes, but disappears from axes upon synaptonemal complex formation. {ECO:0000250|UniProtKB:A0A140LI88}.
Q8N815	reviewed	CNTD1_HUMAN	Cyclin N-terminal domain-containing protein 1	CNTD1 CNTD	Homo sapiens (Human)	330	FUNCTION: Plays a role in the different steps of crossover formation during meiotic recombination. Participates in the crossover differentiation step of crossover-specific recombination intermediates through its interaction with PRR19. In addition, stimulates crossover formation through the interactions with RFC3 and RFC4 and simultaneously regulates cell-cycle progression through interactions with CDC34 and subsequent ubiquitination of WEE1. May also participates in an active deselection process that destabilizes or removes excess pre-CO intermediates. {ECO:0000250|UniProtKB:Q9D995}.		reciprocal meiotic recombination [GO:0007131]; regulation of meiotic cell cycle [GO:0051445]; spermatogenesis [GO:0007283]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]		chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; reciprocal meiotic recombination [GO:0007131]; regulation of meiotic cell cycle [GO:0051445]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D995}. Cytoplasm {ECO:0000250|UniProtKB:Q9D995}. Chromosome {ECO:0000250|UniProtKB:Q9D995}. Note=Shuttles between the nucleus and cytoplasm in a stage-specific manner of prophase I cells. Co-localized at crossover sites with PRR19. {ECO:0000250|UniProtKB:Q9D995}.
Q8N878	reviewed	FRMD1_HUMAN	FERM domain-containing protein 1	FRMD1	Homo sapiens (Human)	549			positive regulation of hippo signaling [GO:0035332]	cytoplasmic side of apical plasma membrane [GO:0098592]; cytoskeleton [GO:0005856]		cytoplasmic side of apical plasma membrane [GO:0098592]; cytoskeleton [GO:0005856]; positive regulation of hippo signaling [GO:0035332]	
Q8N8C0	reviewed	ZN781_HUMAN	Zinc finger protein 781	ZNF781	Homo sapiens (Human)	355	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N8D1	reviewed	PDCD7_HUMAN	Programmed cell death protein 7 (ES18) (hES18)	PDCD7	Homo sapiens (Human)	485	FUNCTION: Promotes apoptosis when overexpressed. {ECO:0000250}.		apoptotic process [GO:0006915]; response to glucocorticoid [GO:0051384]; RNA splicing [GO:0008380]	nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689]		nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689]; apoptotic process [GO:0006915]; response to glucocorticoid [GO:0051384]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N8F7	reviewed	LSME1_HUMAN	Leucine-rich single-pass membrane protein 1	LSMEM1 C7orf53	Homo sapiens (Human)	131		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8N8M0	reviewed	NAT16_HUMAN	Probable N-acetyltransferase 16 (EC 2.3.1.-)	NAT16 C7orf52	Homo sapiens (Human)	369	FUNCTION: Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown. {ECO:0000269|PubMed:24121108}.	MISCELLANEOUS: NAT16 is the ortholog of the ectothermic vertebrates enzyme HISAT (AC I3J7Q8) responsible for the synthesis of N-acetyl-histidine (NAH). NAT16 protein, unlike fish HISAT, has only trace enzyme activity for NAH synthesis. {ECO:0000305|PubMed:24121108}.			acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]	acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]	
Q8N8U2	reviewed	CDYL2_HUMAN	Chromodomain Y-like protein 2 (CDY-like 2)	CDYL2	Homo sapiens (Human)	506				nucleus [GO:0005634]	methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8N8U3	reviewed	RTL3_HUMAN	Retrotransposon Gag-like protein 3 (Zinc finger CCHC domain-containing protein 5)	RTL3 MAR3 MART3 ZCCHC5	Homo sapiens (Human)	475	FUNCTION: May function as a transcriptional regulator. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal. {ECO:0000250|UniProtKB:Q6P1Y1}.	MISCELLANEOUS: RTL3 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. {ECO:0000269|PubMed:16093683}.		nucleus [GO:0005634]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6P1Y1}.
Q8N8Z6	reviewed	DCBD1_HUMAN	Discoidin, CUB and LCCL domain-containing protein 1	DCBLD1	Homo sapiens (Human)	715				membrane [GO:0016020]	signaling receptor activity [GO:0038023]	membrane [GO:0016020]; signaling receptor activity [GO:0038023]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8N944	reviewed	AMER3_HUMAN	APC membrane recruitment protein 3 (Amer3) (Protein FAM123C)	AMER3 FAM123C	Homo sapiens (Human)	861	FUNCTION: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). {ECO:0000250}.		regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055]	plasma membrane [GO:0005886]	beta-catenin binding [GO:0008013]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. {ECO:0000250}.
Q8N957	reviewed	ANKF1_HUMAN	Ankyrin repeat and fibronectin type-III domain-containing protein 1	ANKFN1	Homo sapiens (Human)	1146	FUNCTION: May play a role in neuronal function. {ECO:0000250|UniProtKB:A0A571BF63}.		establishment of mitotic spindle orientation [GO:0000132]; regulation of establishment of bipolar cell polarity [GO:0061172]	spindle [GO:0005819]		spindle [GO:0005819]; establishment of mitotic spindle orientation [GO:0000132]; regulation of establishment of bipolar cell polarity [GO:0061172]	
Q8N961	reviewed	ABTB2_HUMAN	Ankyrin repeat and BTB/POZ domain-containing protein 2	ABTB2	Homo sapiens (Human)	1025	FUNCTION: May be involved in the initiation of hepatocyte growth. {ECO:0000250}.		cellular response to toxic substance [GO:0097237]		protein heterodimerization activity [GO:0046982]	protein heterodimerization activity [GO:0046982]; cellular response to toxic substance [GO:0097237]	
Q8N967	reviewed	LRTM2_HUMAN	Leucine-rich repeat and transmembrane domain-containing protein 2	LRTM2	Homo sapiens (Human)	370			axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; positive regulation of synapse assembly [GO:0051965]	membrane [GO:0016020]	heparin binding [GO:0008201]; Roundabout binding [GO:0048495]	membrane [GO:0016020]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; positive regulation of synapse assembly [GO:0051965]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8N972	reviewed	ZN709_HUMAN	Zinc finger protein 709	ZNF709	Homo sapiens (Human)	641	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N998	reviewed	CCD89_HUMAN	Coiled-coil domain-containing protein 89 (Bc8 orange-interacting protein)	CCDC89 BOIP	Homo sapiens (Human)	374				cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1. {ECO:0000250}.
Q8N9B8	reviewed	RGF1A_HUMAN	Ras-GEF domain-containing family member 1A	RASGEF1A	Homo sapiens (Human)	481	FUNCTION: Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration. {ECO:0000269|PubMed:17121879, ECO:0000269|PubMed:19645719}.		cell migration [GO:0016477]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; cell migration [GO:0016477]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]	
Q8N9F8	reviewed	ZN454_HUMAN	Zinc finger protein 454	ZNF454	Homo sapiens (Human)	522	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N9K5	reviewed	ZN565_HUMAN	Zinc finger protein 565	ZNF565	Homo sapiens (Human)	539	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8N9M1	reviewed	CS047_HUMAN	Uncharacterized protein C19orf47	C19orf47	Homo sapiens (Human)	422				nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]	
Q8N9N7	reviewed	LRC57_HUMAN	Leucine-rich repeat-containing protein 57	LRRC57	Homo sapiens (Human)	239				extracellular exosome [GO:0070062]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Q8N9T8	reviewed	KRI1_HUMAN	Protein KRI1 homolog	KRI1	Homo sapiens (Human)	703			endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]	RNA binding [GO:0003723]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]	
Q8N9U0	reviewed	TAC2N_HUMAN	Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N)	TC2N C14orf47 MTAC2D1	Homo sapiens (Human)	490				nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8N9V7	reviewed	TOPZ1_HUMAN	Protein TOPAZ1 (Testis- and ovary-specific PAZ domain-containing protein 1)	TOPAZ1 C3orf77	Homo sapiens (Human)	1692	FUNCTION: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear. {ECO:0000250|UniProtKB:E5FYH1}.		apoptotic process [GO:0006915]; ectopic germ cell programmed cell death [GO:0035234]; ncRNA transcription [GO:0098781]; spermatocyte division [GO:0048137]	cytosol [GO:0005829]		cytosol [GO:0005829]; apoptotic process [GO:0006915]; ectopic germ cell programmed cell death [GO:0035234]; ncRNA transcription [GO:0098781]; spermatocyte division [GO:0048137]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:E5FYH1}.
Q8N9W8	reviewed	GAR2_HUMAN	Golgi-associated RAB2 interactor protein 2	GARIN2 C14orf54 FAM71D	Homo sapiens (Human)	422	FUNCTION: Seems to play a role in sperm motility. {ECO:0000305|PubMed:29025071}.		flagellated sperm motility [GO:0030317]	sperm midpiece [GO:0097225]		sperm midpiece [GO:0097225]; flagellated sperm motility [GO:0030317]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:D3YV92}. Note=In mature sperm, localizes in the midpiece of flagella. {ECO:0000250|UniProtKB:D3YV92}.
Q8N9Y4	reviewed	F181A_HUMAN	Protein FAM181A	FAM181A C14orf152 HSD-31 HSD31	Homo sapiens (Human)	354				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q8N9Z9	reviewed	LMTD1_HUMAN	Lamin tail domain-containing protein 1 (Intermediate filament tail domain-containing protein 1)	LMNTD1 IFLTD1	Homo sapiens (Human)	388			cell population proliferation [GO:0008283]	cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; nuclear envelope [GO:0005635]		cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; nuclear envelope [GO:0005635]; cell population proliferation [GO:0008283]	
Q8NA03	reviewed	FSIP1_HUMAN	Fibrous sheath-interacting protein 1	FSIP1 HSD10	Homo sapiens (Human)	581							
Q8NA23	reviewed	WDR31_HUMAN	WD repeat-containing protein 31	WDR31	Homo sapiens (Human)	367							
Q8NA47	reviewed	CCD63_HUMAN	Coiled-coil domain-containing protein 63	CCDC63	Homo sapiens (Human)	563	FUNCTION: Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads. {ECO:0000250|UniProtKB:Q8CDV6}.		cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]; spermatid development [GO:0007286]	axoneme [GO:0005930]		axoneme [GO:0005930]; cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]; spermatid development [GO:0007286]	
Q8NA69	reviewed	SAXO5_HUMAN	Stabilizer of axonemal microtubules 5 (Testis-expressed protein 45)	SAXO5 C19orf45 TEX45	Homo sapiens (Human)	505							
Q8NA92	reviewed	THAP8_HUMAN	THAP domain-containing protein 8	THAP8	Homo sapiens (Human)	274					DNA binding [GO:0003677]; metal ion binding [GO:0046872]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	
Q8NB37	reviewed	GALD1_HUMAN	Glutamine amidotransferase-like class 1 domain-containing protein 1 (Parkinson disease 7 domain-containing protein 1)	GATD1 PDDC1	Homo sapiens (Human)	220			methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	glyoxalase III activity [GO:0019172]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; glyoxalase III activity [GO:0019172]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8NB42	reviewed	ZN527_HUMAN	Zinc finger protein 527	ZNF527 KIAA1829	Homo sapiens (Human)	609	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NB46	reviewed	ANR52_HUMAN	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) (Ankyrin repeat domain-containing protein 52)	ANKRD52	Homo sapiens (Human)	1076	FUNCTION: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.						
Q8NB50	reviewed	ZFP62_HUMAN	Zinc finger protein 62 homolog (Zfp-62)	ZFP62	Homo sapiens (Human)	900	FUNCTION: May play a role in differentiating skeletal muscle. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NBL3	reviewed	T178A_HUMAN	Transmembrane protein 178A	TMEM178A TMEM178 PSEC0131 UNQ5926/PRO19820	Homo sapiens (Human)	297	FUNCTION: Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. {ECO:0000250|UniProtKB:Q9CZ16}.		negative regulation of osteoclast differentiation [GO:0045671]; regulation of cytosolic calcium ion concentration [GO:0051480]	endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]; negative regulation of osteoclast differentiation [GO:0045671]; regulation of cytosolic calcium ion concentration [GO:0051480]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9CZ16}; Multi-pass membrane protein {ECO:0000255}.
Q8NC74	reviewed	RB8NL_HUMAN	RBBP8 N-terminal-like protein	RBBP8NL C20orf151	Homo sapiens (Human)	664				extracellular space [GO:0005615]		extracellular space [GO:0005615]	
Q8NCI6	reviewed	GLBL3_HUMAN	Beta-galactosidase-1-like protein 3 (EC 3.2.1.-)	GLB1L3	Homo sapiens (Human)	653			carbohydrate metabolic process [GO:0005975]	lysosome [GO:0005764]; vacuole [GO:0005773]	beta-galactosidase activity [GO:0004565]	lysosome [GO:0005764]; vacuole [GO:0005773]; beta-galactosidase activity [GO:0004565]; carbohydrate metabolic process [GO:0005975]	
Q8NCL9	reviewed	APCDL_HUMAN	Protein APCDD1-like (Adenomatosis polyposis coli down-regulated 1 protein-like)	APCDD1L	Homo sapiens (Human)	501			negative regulation of Wnt signaling pathway [GO:0030178]	plasma membrane [GO:0005886]	Wnt-protein binding [GO:0017147]	plasma membrane [GO:0005886]; Wnt-protein binding [GO:0017147]; negative regulation of Wnt signaling pathway [GO:0030178]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8NCN5	reviewed	PDPR_HUMAN	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr)	PDPR KIAA1990	Homo sapiens (Human)	879	FUNCTION: Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine. {ECO:0000250}.			cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase (lipoamide) phosphatase complex [GO:0045253]	oxidoreductase activity [GO:0016491]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase (lipoamide) phosphatase complex [GO:0045253]; oxidoreductase activity [GO:0016491]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
Q8NCQ5	reviewed	FBX15_HUMAN	F-box only protein 15	FBXO15 FBX15	Homo sapiens (Human)	510	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.			cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]		cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	
Q8NCR9	reviewed	CLRN3_HUMAN	Clarin-3 (Transmembrane protein 12) (Usher syndrome type-3A-like protein 1)	CLRN3 TMEM12 USH3AL1	Homo sapiens (Human)	226			sensory perception of sound [GO:0007605]	extracellular exosome [GO:0070062]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; membrane [GO:0016020]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NCX0	reviewed	CC150_HUMAN	Coiled-coil domain-containing protein 150	CCDC150	Homo sapiens (Human)	1101							
Q8ND07	reviewed	BBOF1_HUMAN	Basal body-orientation factor 1 (Coiled-coil domain-containing protein 176)	BBOF1 C14orf45 CCDC176	Homo sapiens (Human)	529	FUNCTION: Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity). {ECO:0000250}.		motile cilium assembly [GO:0044458]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]		ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; motile cilium assembly [GO:0044458]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Localizes to a polar structure adjacent to the basal body. {ECO:0000250}.
Q8ND61	reviewed	CC020_HUMAN	Uncharacterized protein C3orf20	C3orf20	Homo sapiens (Human)	904				cytoplasm [GO:0005737]; membrane [GO:0016020]		cytoplasm [GO:0005737]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8NDA8	reviewed	MROH1_HUMAN	Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A)	MROH1 HEATR7A KIAA1833	Homo sapiens (Human)	1641				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q8NDW4	reviewed	ZN248_HUMAN	Zinc finger protein 248	ZNF248	Homo sapiens (Human)	579	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NDY3	reviewed	ARHL1_HUMAN	Inactive ADP-ribosyltransferase ARH2 (ADP-ribosylhydrolase-like protein 1) ([Protein ADP-ribosylarginine] hydrolase-like protein 1)	ADPRHL1 ARH2	Homo sapiens (Human)	354	FUNCTION: Required for myofibril assembly and outgrowth of the cardiac chambers in the developing heart (By similarity). Appears to be catalytically inactive, showing no activity against O-acetyl-ADP-ribose (By similarity). {ECO:0000250|UniProtKB:Q6AZR2, ECO:0000250|UniProtKB:Q8BGK2}.		cardiac chamber ballooning [GO:0003242]; cardiac myofibril assembly [GO:0055003]	sarcomere [GO:0030017]	ADP-ribosylarginine hydrolase activity [GO:0003875]; magnesium ion binding [GO:0000287]	sarcomere [GO:0030017]; ADP-ribosylarginine hydrolase activity [GO:0003875]; magnesium ion binding [GO:0000287]; cardiac chamber ballooning [GO:0003242]; cardiac myofibril assembly [GO:0055003]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q6AZR2}.
Q8NDY6	reviewed	BHE23_HUMAN	Class E basic helix-loop-helix protein 23 (bHLHe23) (Class B basic helix-loop-helix protein 4) (bHLHb4)	BHLHE23 BHLHB4	Homo sapiens (Human)	225	FUNCTION: May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity). {ECO:0000250}.		axon development [GO:0061564]; neuron fate commitment [GO:0048663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]; axon development [GO:0061564]; neuron fate commitment [GO:0048663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NDZ0	reviewed	BEND2_HUMAN	BEN domain-containing protein 2	BEND2 CXorf20	Homo sapiens (Human)	799					DNA binding [GO:0003677]	DNA binding [GO:0003677]	
Q8NDZ6	reviewed	T161B_HUMAN	Transmembrane protein 161B	TMEM161B UNQ679/PRO1313	Homo sapiens (Human)	487	FUNCTION: Essential for maintaining normal cardiac rhythm in the developing heart and for neonatal survival (By similarity). Inhibits potassium and calcium currents in the cardiomyocytes, this assists in timely action potential repolarization and thereby maintains normal cardiac rhythm (By similarity). {ECO:0000250|UniProtKB:Q8C2L6}.		regulation of cardiac muscle cell action potential [GO:0098901]; regulation of heart rate [GO:0002027]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of heart rate [GO:0002027]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7SY10}; Multi-pass membrane protein {ECO:0000255}.
Q8NE00	reviewed	TM104_HUMAN	Transmembrane protein 104	TMEM104	Homo sapiens (Human)	496				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NE18	reviewed	NSUN7_HUMAN	Putative methyltransferase NSUN7 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 7)	NSUN7	Homo sapiens (Human)	718	FUNCTION: May have S-adenosyl-L-methionine-dependent methyl-transferase activity. {ECO:0000305}.		methylation [GO:0032259]		RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; methylation [GO:0032259]	
Q8NE22	reviewed	SETD9_HUMAN	SET domain-containing protein 9 (EC 2.1.1.-)	SETD9 C5orf35	Homo sapiens (Human)	299			methylation [GO:0032259]; regulation of signal transduction by p53 class mediator [GO:1901796]	nucleoplasm [GO:0005654]	lysine N-methyltransferase activity [GO:0016278]	nucleoplasm [GO:0005654]; lysine N-methyltransferase activity [GO:0016278]; methylation [GO:0032259]; regulation of signal transduction by p53 class mediator [GO:1901796]	
Q8NE65	reviewed	ZN738_HUMAN	Zinc finger protein 738	ZNF738	Homo sapiens (Human)	375	FUNCTION: May be involved in transcriptional regulation.	MISCELLANEOUS: [Isoform 1]: Gene prediction based on partial EST data. {ECO:0000305}.	protein polyubiquitination [GO:0000209]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]	nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; protein polyubiquitination [GO:0000209]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NEA5	reviewed	CS018_HUMAN	Uncharacterized protein C19orf18	C19orf18	Homo sapiens (Human)	215				extracellular exosome [GO:0070062]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8NEC7	reviewed	GSTCD_HUMAN	Glutathione S-transferase C-terminal domain-containing protein	GSTCD	Homo sapiens (Human)	633				cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24058608}.
Q8NEG4	reviewed	FA83F_HUMAN	Protein FAM83F	FAM83F	Homo sapiens (Human)	500			signal transduction [GO:0007165]		protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]; signal transduction [GO:0007165]	
Q8NEG5	reviewed	ZSWM2_HUMAN	E3 ubiquitin-protein ligase ZSWIM2 (EC 2.3.2.27) (MEKK1-related protein X) (MEX) (RING-type E3 ubiquitin transferase ZSWIM2) (ZZ-type zinc finger-containing protein 2) (Zinc finger SWIM domain-containing protein 2)	ZSWIM2 ZZZ2	Homo sapiens (Human)	633	FUNCTION: E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes. {ECO:0000250}.		apoptotic process [GO:0006915]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]		protein self-association [GO:0043621]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	protein self-association [GO:0043621]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]	
Q8NEG7	reviewed	DEN6B_HUMAN	Protein DENND6B (DENN domain-containing protein 6B)	DENND6B FAM116B	Homo sapiens (Human)	585	FUNCTION: Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35. {ECO:0000269|PubMed:22595670}.			cytosol [GO:0005829]; recycling endosome [GO:0055037]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; recycling endosome [GO:0055037]; guanyl-nucleotide exchange factor activity [GO:0005085]	SUBCELLULAR LOCATION: Recycling endosome {ECO:0000305}. Cytoplasm {ECO:0000305}.
Q8NEK5	reviewed	ZN548_HUMAN	Zinc finger protein 548	ZNF548	Homo sapiens (Human)	533	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NEM1	reviewed	ZN680_HUMAN	Zinc finger protein 680	ZNF680	Homo sapiens (Human)	530	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8NEM2	reviewed	SHCBP_HUMAN	SHC SH2 domain-binding protein 1	SHCBP1	Homo sapiens (Human)	672	FUNCTION: May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. {ECO:0000250|UniProtKB:Q9Z179}.		fibroblast growth factor receptor signaling pathway [GO:0008543]; regulation of neural precursor cell proliferation [GO:2000177]	cytoplasm [GO:0005737]; midbody [GO:0030496]; spindle [GO:0005819]	SH2 domain binding [GO:0042169]	cytoplasm [GO:0005737]; midbody [GO:0030496]; spindle [GO:0005819]; SH2 domain binding [GO:0042169]; fibroblast growth factor receptor signaling pathway [GO:0008543]; regulation of neural precursor cell proliferation [GO:2000177]	SUBCELLULAR LOCATION: Midbody {ECO:0000269|PubMed:21187330}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:21187330}. Note=Displays weak localization to the spindle midzone in some early telophase cells and is concentrated at the midbody in late cytokinesis. {ECO:0000269|PubMed:21187330}.
Q8NEP7	reviewed	KLDC9_HUMAN	Kelch domain-containing protein 9 (Kelch/ankyrin repeat-containing cyclin A1-interacting protein)	KLHDC9 KARCA1	Homo sapiens (Human)	349					cyclin binding [GO:0030332]	cyclin binding [GO:0030332]	
Q8NES8	reviewed	DB124_HUMAN	Beta-defensin 124 (Beta-defensin 24) (DEFB-24) (Defensin, beta 124)	DEFB124 DEFB24	Homo sapiens (Human)	71	FUNCTION: Has antibacterial activity. {ECO:0000305}.		canonical NF-kappaB signal transduction [GO:0007249]; cellular response to peptidoglycan [GO:0071224]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of monocyte chemotaxis [GO:0090026]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to peptidoglycan [GO:0071224]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of monocyte chemotaxis [GO:0090026]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8NEY3	reviewed	SPAT4_HUMAN	Spermatogenesis-associated protein 4 (Testis and spermatogenesis cell-related protein 2) (Testis spermatocyte apoptosis-related gene 2 protein)	SPATA4 TSARG2	Homo sapiens (Human)	305	FUNCTION: May play a role in apoptosis regulation. {ECO:0000269|PubMed:26424010}.		regulation of cytoskeleton organization [GO:0051493]	axoneme [GO:0005930]; nucleus [GO:0005634]	microtubule binding [GO:0008017]	axoneme [GO:0005930]; nucleus [GO:0005634]; microtubule binding [GO:0008017]; regulation of cytoskeleton organization [GO:0051493]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15158438}.
Q8NFI4	reviewed	F10A5_HUMAN	Putative protein FAM10A5 (Suppression of tumorigenicity 13 pseudogene 5)	ST13P5 FAM10A5	Homo sapiens (Human)	369				cytoplasm [GO:0005737]	protein dimerization activity [GO:0046983]	cytoplasm [GO:0005737]; protein dimerization activity [GO:0046983]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8NFQ5	reviewed	BPIB6_HUMAN	BPI fold-containing family B member 6 (Bactericidal/permeability-increasing protein-like 3)	BPIFB6 BPIL3	Homo sapiens (Human)	453				extracellular region [GO:0005576]	lipid binding [GO:0008289]	extracellular region [GO:0005576]; lipid binding [GO:0008289]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q8NFQ6	reviewed	BPIFC_HUMAN	BPI fold-containing family C protein (Bactericidal/permeability-increasing protein-like 2) (BPI-like 2)	BPIFC BPIL2	Homo sapiens (Human)	507			innate immune response [GO:0045087]	extracellular space [GO:0005615]	lipopolysaccharide binding [GO:0001530]; phospholipid binding [GO:0005543]	extracellular space [GO:0005615]; lipopolysaccharide binding [GO:0001530]; phospholipid binding [GO:0005543]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P17213}.
Q8NFR7	reviewed	CC148_HUMAN	Coiled-coil domain-containing protein 148	CCDC148	Homo sapiens (Human)	591							
Q8NFU4	reviewed	FDSCP_HUMAN	Follicular dendritic cell secreted peptide (FDC secreted protein) (FDC-SP)	FDCSP C4orf7 UNQ733/PRO1419	Homo sapiens (Human)	85	FUNCTION: Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.			extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted.
Q8NFZ6	reviewed	VN1R2_HUMAN	Vomeronasal type-1 receptor 2 (G-protein coupled receptor GPCR25) (hGPCR25) (V1r-like receptor 2)	VN1R2 V1RL2	Homo sapiens (Human)	395	FUNCTION: Putative pheromone receptor.	MISCELLANEOUS: The chimpanzee, gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.	response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606]	plasma membrane [GO:0005886]	pheromone receptor activity [GO:0016503]	plasma membrane [GO:0005886]; pheromone receptor activity [GO:0016503]; response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG35	reviewed	D105A_HUMAN	Beta-defensin 105 (Beta-defensin 5) (BD-5) (DEFB-5) (Defensin, beta 105)	DEFB105A BD5 DEFB105 DEFB5; DEFB105B	Homo sapiens (Human)	78	FUNCTION: Has antibacterial activity. {ECO:0000305}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted.
Q8NG41	reviewed	NPB_HUMAN	Neuropeptide B (Preproprotein L7) (hPPL7) [Cleaved into: Neuropeptide B-23 (NPB23) (hL7); Neuropeptide B-29 (NPB29) (hL7C)]	NPB PPL7 PPNPB	Homo sapiens (Human)	125	FUNCTION: May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. {ECO:0000250}.		feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	extracellular region [GO:0005576]	G protein-coupled receptor binding [GO:0001664]	extracellular region [GO:0005576]; G protein-coupled receptor binding [GO:0001664]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Secreted.
Q8NG75	reviewed	OR5T1_HUMAN	Olfactory receptor 5T1 (Olfactory receptor OR11-179)	OR5T1 OR5T1P	Homo sapiens (Human)	326	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG76	reviewed	O2T33_HUMAN	Olfactory receptor 2T33 (Olfactory receptor OR1-56)	OR2T33	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG77	reviewed	O2T12_HUMAN	Olfactory receptor 2T12 (Olfactory receptor OR1-57)	OR2T12	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG78	reviewed	OR8G5_HUMAN	Olfactory receptor 8G5 (Olfactory receptor 8G6) (Olfactory receptor OR11-298)	OR8G5 OR8G5P OR8G6	Homo sapiens (Human)	346	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG80	reviewed	OR2L5_HUMAN	Olfactory receptor 2L5 (Olfactory receptor 2L11) (Olfactory receptor OR1-53)	OR2L5 OR2L11	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG81	reviewed	OR2M7_HUMAN	Olfactory receptor 2M7 (Olfactory receptor OR1-58)	OR2M7	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG83	reviewed	OR2M3_HUMAN	Olfactory receptor 2M3 (Olfactory receptor 2M6) (Olfactory receptor OR1-54)	OR2M3 OR2M3P OR2M6	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG84	reviewed	O2AK2_HUMAN	Olfactory receptor 2AK2 (Olfactory receptor 2AK1) (Olfactory receptor OR1-47)	OR2AK2 OR2AK1P	Homo sapiens (Human)	335	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG85	reviewed	OR2L3_HUMAN	Olfactory receptor 2L3	OR2L3	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG92	reviewed	O13H1_HUMAN	Olfactory receptor 13H1 (Olfactory receptor ORX-1)	OR13H1	Homo sapiens (Human)	308	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG94	reviewed	O11H1_HUMAN	Olfactory receptor 11H1 (Olfactory receptor OR22-1)	OR11H1	Homo sapiens (Human)	326	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG95	reviewed	OR7G3_HUMAN	Olfactory receptor 7G3 (OST085) (Olfactory receptor OR19-9)	OR7G3	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG97	reviewed	OR2Z1_HUMAN	Olfactory receptor 2Z1 (Olfactory receptor 2Z2) (Olfactory receptor OR19-4)	OR2Z1 OR2Z2	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NG99	reviewed	OR7G2_HUMAN	Olfactory receptor 7G2 (OST260) (Olfactory receptor 19-13) (OR19-13) (Olfactory receptor OR19-6)	OR7G2	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGA1	reviewed	OR1M1_HUMAN	Olfactory receptor 1M1 (Olfactory receptor 19-6) (OR19-6) (Olfactory receptor OR19-5)	OR1M1	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q8NGA2	reviewed	OR7A2_HUMAN	Putative olfactory receptor 7A2 (Putative olfactory receptor 7A7)	OR7A2P OR7A2 OR7A7	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGA5	reviewed	O10H4_HUMAN	Olfactory receptor 10H4 (Olfactory receptor OR19-28)	OR10H4	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGA6	reviewed	O10H5_HUMAN	Olfactory receptor 10H5 (Olfactory receptor OR19-25) (Olfactory receptor OR19-26)	OR10H5	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGA8	reviewed	O4F17_HUMAN	Olfactory receptor 4F17 (Olfactory receptor 4F11) (Olfactory receptor 4F18) (Olfactory receptor 4F19)	OR4F17 OR4F11P OR4F18 OR4F19	Homo sapiens (Human)	305	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGB2	reviewed	OR4C5_HUMAN	Olfactory receptor 4C5 (Olfactory receptor OR11-99)	OR4C5	Homo sapiens (Human)	326	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGB4	reviewed	OR4S1_HUMAN	Olfactory receptor 4S1 (Olfactory receptor OR11-100)	OR4S1	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGB6	reviewed	OR4M2_HUMAN	Olfactory receptor 4M2 (Olfactory receptor OR15-3)	OR4M2	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGB8	reviewed	O4F15_HUMAN	Olfactory receptor 4F15 (Olfactory receptor OR15-14)	OR4F15	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGB9	reviewed	OR4F6_HUMAN	Olfactory receptor 4F6 (Olfactory receptor 4F12) (Olfactory receptor OR15-15)	OR4F6 OR4F12	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGC0	reviewed	O5AU1_HUMAN	Olfactory receptor 5AU1 (Olfactory receptor OR14-38)	OR5AU1	Homo sapiens (Human)	362	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGC1	reviewed	O11G2_HUMAN	Olfactory receptor 11G2 (Olfactory receptor OR14-34)	OR11G2	Homo sapiens (Human)	345	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGC2	reviewed	OR4E2_HUMAN	Olfactory receptor 4E2 (Olfactory receptor OR14-42)	OR4E2	Homo sapiens (Human)	313	FUNCTION: Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT) and bis(methylthiomethyl) disulfide (By similarity). Also binds odorants cis-cyclooctene and tert-butyl mercaptan (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250|UniProtKB:Q7TQQ0}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; metal ion binding [GO:0046872]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; metal ion binding [GO:0046872]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7TQQ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7TQQ0}.
Q8NGC3	reviewed	O10G2_HUMAN	Olfactory receptor 10G2	OR10G2	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGC4	reviewed	O10G3_HUMAN	Olfactory receptor 10G3 (Olfactory receptor OR14-40)	OR10G3	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGC5	reviewed	OR6J1_HUMAN	Olfactory receptor 6J1 (Olfactory receptor 6J2)	OR6J1 OR6J2	Homo sapiens (Human)	347	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGC6	reviewed	OR4KH_HUMAN	Olfactory receptor 4K17 (Olfactory receptor OR14-29)	OR4K17	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGC7	reviewed	O11H6_HUMAN	Olfactory receptor 11H6 (Olfactory receptor OR14-35)	OR11H6	Homo sapiens (Human)	330	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGC9	reviewed	O11H4_HUMAN	Olfactory receptor 11H4 (Olfactory receptor OR14-36)	OR11H4	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGD1	reviewed	OR4N2_HUMAN	Olfactory receptor 4N2 (Olfactory receptor OR14-13) (Olfactory receptor OR14-8)	OR4N2	Homo sapiens (Human)	307	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGD2	reviewed	OR4K2_HUMAN	Olfactory receptor 4K2 (Olfactory receptor OR14-15)	OR4K2	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGD3	reviewed	OR4K5_HUMAN	Olfactory receptor 4K5 (Olfactory receptor OR14-16)	OR4K5	Homo sapiens (Human)	323	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGD4	reviewed	OR4K1_HUMAN	Olfactory receptor 4K1 (Olfactory receptor OR14-19)	OR4K1	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGD5	reviewed	OR4KE_HUMAN	Olfactory receptor 4K14 (Olfactory receptor OR14-22)	OR4K14	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGE0	reviewed	O10AD_HUMAN	Olfactory receptor 10AD1 (Olfactory receptor OR12-1)	OR10AD1 OR10AD1P	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGE1	reviewed	OR6C4_HUMAN	Olfactory receptor 6C4 (Olfactory receptor OR12-10)	OR6C4	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGE2	reviewed	O2AP1_HUMAN	Olfactory receptor 2AP1 (Olfactory receptor OR12-9)	OR2AP1 OR2AP1P	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGE5	reviewed	O10A7_HUMAN	Olfactory receptor 10A7 (Olfactory receptor OR12-6)	OR10A7	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGE7	reviewed	OR9K2_HUMAN	Olfactory receptor 9K2 (Olfactory receptor OR12-2)	OR9K2	Homo sapiens (Human)	335	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGE8	reviewed	OR4D9_HUMAN	Olfactory receptor 4D9 (Olfactory receptor OR11-253)	OR4D9	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGE9	reviewed	OR9Q2_HUMAN	Olfactory receptor 9Q2	OR9Q2 OR9Q2P	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGF0	reviewed	O52B6_HUMAN	Olfactory receptor 52B6 (Olfactory receptor OR11-47)	OR52B6	Homo sapiens (Human)	335	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGF1	reviewed	O52R1_HUMAN	Olfactory receptor 52R1 (Olfactory receptor OR11-22)	OR52R1	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGF3	reviewed	O51D1_HUMAN	Olfactory receptor 51D1 (Olfactory receptor OR11-14)	OR51D1	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGF4	reviewed	O5AP2_HUMAN	Olfactory receptor 5AP2	OR5AP2	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q8NGF6	reviewed	O10W1_HUMAN	Olfactory receptor 10W1 (Olfactory receptor OR11-236)	OR10W1 OR10W1P UNQ6469/PRO34070	Homo sapiens (Human)	305	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGF7	reviewed	OR5BH_HUMAN	Olfactory receptor 5B17 (Olfactory receptor 5B20) (Olfactory receptor OR11-237)	OR5B17 OR5B20P	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGF8	reviewed	OR4B1_HUMAN	Olfactory receptor 4B1 (OST208) (Olfactory receptor OR11-106)	OR4B1	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGF9	reviewed	OR4X2_HUMAN	Olfactory receptor 4X2 (Olfactory receptor OR11-105)	OR4X2	Homo sapiens (Human)	303	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGG0	reviewed	OR8J3_HUMAN	Olfactory receptor 8J3 (Olfactory receptor OR11-173)	OR8J3	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGG1	reviewed	OR8J2_HUMAN	Olfactory receptor 8J2	OR8J2 OR8J2P	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	membrane [GO:0016020]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NGG3	reviewed	OR5T3_HUMAN	Olfactory receptor 5T3 (Olfactory receptor OR11-178)	OR5T3	Homo sapiens (Human)	340	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGG4	reviewed	OR8H1_HUMAN	Olfactory receptor 8H1 (Olfactory receptor OR11-180)	OR8H1	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGG5	reviewed	OR8K1_HUMAN	Olfactory receptor 8K1 (Olfactory receptor OR11-182)	OR8K1	Homo sapiens (Human)	319	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGG6	reviewed	OR8BC_HUMAN	Olfactory receptor 8B12 (Olfactory receptor OR11-317)	OR8B12	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGG7	reviewed	OR8A1_HUMAN	Olfactory receptor 8A1 (OST025) (Olfactory receptor OR11-318)	OR8A1	Homo sapiens (Human)	326	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGG8	reviewed	OR8B3_HUMAN	Olfactory receptor 8B3 (Olfactory receptor OR11-311)	OR8B3	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGH3	reviewed	OR2D3_HUMAN	Olfactory receptor 2D3 (Olfactory receptor OR11-89)	OR2D3	Homo sapiens (Human)	330	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGH5	reviewed	O56A1_HUMAN	Olfactory receptor 56A1 (Olfactory receptor OR11-75)	OR56A1	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGH6	reviewed	O52L2_HUMAN	Putative olfactory receptor 52L2 (Olfactory receptor OR11-74)	OR52L2P OR52L2	Homo sapiens (Human)	319	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGH8	reviewed	O56A4_HUMAN	Olfactory receptor 56A4 (Olfactory receptor OR11-49)	OR56A4	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGH9	reviewed	O52E4_HUMAN	Olfactory receptor 52E4 (Olfactory receptor OR11-55)	OR52E4	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGI0	reviewed	O52N2_HUMAN	Olfactory receptor 52N2 (Olfactory receptor OR11-57)	OR52N2	Homo sapiens (Human)	321	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGI1	reviewed	O56B2_HUMAN	Putative olfactory receptor 56B2	OR56B2P	Homo sapiens (Human)	322	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGI3	reviewed	O56B1_HUMAN	Olfactory receptor 56B1 (Olfactory receptor OR11-65)	OR56B1 OR56B1P	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGI4	reviewed	OR4DB_HUMAN	Olfactory receptor 4D11	OR4D11 OR4D11P	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGI6	reviewed	OR4DA_HUMAN	Olfactory receptor 4D10 (Olfactory receptor OR11-251)	OR4D10 OR4D10P	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGI7	reviewed	O10V1_HUMAN	Olfactory receptor 10V1 (Olfactory receptor OR11-256)	OR10V1	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGI9	reviewed	OR5A2_HUMAN	Olfactory receptor 5A2 (Olfactory receptor OR11-248)	OR5A2	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGJ0	reviewed	OR5A1_HUMAN	Olfactory receptor 5A1 (OST181) (Olfactory receptor OR11-249)	OR5A1 OR5A1P	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGJ1	reviewed	OR4D6_HUMAN	Olfactory receptor 4D6 (Olfactory receptor OR11-250)	OR4D6	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGJ3	reviewed	O52E1_HUMAN	Olfactory receptor 52E1	OR52E1 OR52E1P	Homo sapiens (Human)	308	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGJ4	reviewed	O52E2_HUMAN	Olfactory receptor 52E2	OR52E2	Homo sapiens (Human)	325	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGJ5	reviewed	O51L1_HUMAN	Olfactory receptor 51L1 (Olfactory receptor OR11-31)	OR51L1	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGJ6	reviewed	O51A4_HUMAN	Olfactory receptor 51A4	OR51A4	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGJ7	reviewed	O51A2_HUMAN	Olfactory receptor 51A2	OR51A2	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGJ8	reviewed	O51S1_HUMAN	Olfactory receptor 51S1 (Olfactory receptor OR11-24)	OR51S1	Homo sapiens (Human)	323	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGJ9	reviewed	O51T1_HUMAN	Olfactory receptor 51T1 (Olfactory receptor OR11-26)	OR51T1	Homo sapiens (Human)	327	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGK0	reviewed	O51G2_HUMAN	Olfactory receptor 51G2 (Olfactory receptor OR11-28)	OR51G2	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGK1	reviewed	O51G1_HUMAN	Olfactory receptor 51G1 (Olfactory receptor 51G3) (Olfactory receptor OR11-29)	OR51G1 OR51G3P	Homo sapiens (Human)	321	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGK3	reviewed	O52K2_HUMAN	Olfactory receptor 52K2 (Olfactory receptor OR11-7)	OR52K2	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGK4	reviewed	O52K1_HUMAN	Olfactory receptor 52K1 (Olfactory receptor OR11-8)	OR52K1	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGK5	reviewed	O52M1_HUMAN	Olfactory receptor 52M1 (Olfactory receptor OR11-11)	OR52M1 OR52M1P	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGK6	reviewed	O52I1_HUMAN	Olfactory receptor 52I1 (Olfactory receptor OR11-13)	OR52I1	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGK9	reviewed	OR5DG_HUMAN	Olfactory receptor 5D16 (Olfactory receptor OR11-154)	OR5D16	Homo sapiens (Human)	328	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGL0	reviewed	OR5L2_HUMAN	Olfactory receptor 5L2 (HTPCRX16) (Olfactory receptor OR11-153)	OR5L2	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGL1	reviewed	OR5DI_HUMAN	Olfactory receptor 5D18 (Olfactory receptor OR11-143) (Olfactory receptor OR11-152)	OR5D18	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGL2	reviewed	OR5L1_HUMAN	Olfactory receptor 5L1 (OST262) (Olfactory receptor OR11-151)	OR5L1	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGL3	reviewed	OR5DE_HUMAN	Olfactory receptor 5D14 (Olfactory receptor OR11-141) (Olfactory receptor OR11-150)	OR5D14	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGL4	reviewed	OR5DD_HUMAN	Olfactory receptor 5D13 (Olfactory receptor OR11-142) (Olfactory receptor OR11-148)	OR5D13	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGL6	reviewed	O4A15_HUMAN	Olfactory receptor 4A15 (Olfactory receptor OR11-118)	OR4A15	Homo sapiens (Human)	344	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGL7	reviewed	OR4P4_HUMAN	Olfactory receptor 4P4 (Olfactory receptor 4P3)	OR4P4 OR4P3P	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGL9	reviewed	OR4CG_HUMAN	Olfactory receptor 4C16 (Olfactory receptor OR11-135)	OR4C16	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGM1	reviewed	OR4CF_HUMAN	Olfactory receptor 4C15 (Olfactory receptor OR11-127) (Olfactory receptor OR11-134)	OR4C15	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGM8	reviewed	OR6M1_HUMAN	Olfactory receptor 6M1 (Olfactory receptor OR11-271)	OR6M1	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGN0	reviewed	OR4D5_HUMAN	Olfactory receptor 4D5 (Olfactory receptor OR11-276)	OR4D5	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGN1	reviewed	OR6T1_HUMAN	Olfactory receptor 6T1 (Olfactory receptor OR11-277)	OR6T1	Homo sapiens (Human)	323	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGN2	reviewed	O10S1_HUMAN	Olfactory receptor 10S1 (Olfactory receptor OR11-279)	OR10S1	Homo sapiens (Human)	331	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGN4	reviewed	O10G9_HUMAN	Olfactory receptor 10G9 (Olfactory receptor 10G10)	OR10G9 OR10G10P	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGN5	reviewed	O10G8_HUMAN	Olfactory receptor 10G8 (Olfactory receptor OR11-282)	OR10G8	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGN6	reviewed	O10G7_HUMAN	Olfactory receptor 10G7 (Olfactory receptor OR11-283)	OR10G7	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGN7	reviewed	O10D4_HUMAN	Putative olfactory receptor 10D4	OR10D4P OR10D4	Homo sapiens (Human)	298	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGN8	reviewed	OR4A4_HUMAN	Putative olfactory receptor 4A4 (Olfactory receptor OR11-107)	OR4A4P	Homo sapiens (Human)	299	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGP0	reviewed	OR4CD_HUMAN	Olfactory receptor 4C13 (Olfactory receptor OR11-260)	OR4C13	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGP2	reviewed	OR8J1_HUMAN	Olfactory receptor 8J1 (Olfactory receptor OR11-183)	OR8J1	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGP3	reviewed	OR5M9_HUMAN	Olfactory receptor 5M9 (Olfactory receptor OR11-190)	OR5M9	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGP4	reviewed	OR5M3_HUMAN	Olfactory receptor 5M3 (Olfactory receptor OR11-191)	OR5M3	Homo sapiens (Human)	307	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGP6	reviewed	OR5M8_HUMAN	Olfactory receptor 5M8 (Olfactory receptor OR11-194)	OR5M8	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGP8	reviewed	OR5M1_HUMAN	Olfactory receptor 5M1 (OST050) (Olfactory receptor OR11-208)	OR5M1	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGP9	reviewed	O5AR1_HUMAN	Olfactory receptor 5AR1 (Olfactory receptor OR11-209)	OR5AR1	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	copper ion binding [GO:0005507]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; copper ion binding [GO:0005507]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VGS3}; Multi-pass membrane protein {ECO:0000255}.
Q8NGQ2	reviewed	OR6Q1_HUMAN	Olfactory receptor 6Q1 (Olfactory receptor OR11-226)	OR6Q1	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGQ3	reviewed	OR1S2_HUMAN	Olfactory receptor 1S2 (Olfactory receptor OR11-231)	OR1S2	Homo sapiens (Human)	325	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGQ4	reviewed	O10Q1_HUMAN	Olfactory receptor 10Q1 (Olfactory receptor OR11-233)	OR10Q1	Homo sapiens (Human)	319	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGQ5	reviewed	OR9Q1_HUMAN	Olfactory receptor 9Q1	OR9Q1	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGQ6	reviewed	OR9I1_HUMAN	Olfactory receptor 9I1 (Olfactory receptor OR11-228)	OR9I1	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGR1	reviewed	O13A1_HUMAN	Olfactory receptor 13A1 (Olfactory receptor OR10-3)	OR13A1	Homo sapiens (Human)	328	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGR3	reviewed	OR1K1_HUMAN	Olfactory receptor 1K1	OR1K1	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGR4	reviewed	OR5C1_HUMAN	Olfactory receptor 5C1 (Olfactory receptor 5C2) (Olfactory receptor 9-F) (OR9-F)	OR5C1 OR5C2P	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGR5	reviewed	OR1L4_HUMAN	Olfactory receptor 1L4 (OST046) (Olfactory receptor 1L5) (Olfactory receptor 9-E) (OR9-E) (Olfactory receptor OR9-29)	OR1L4 OR1L5	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGR8	reviewed	OR1L8_HUMAN	Olfactory receptor 1L8 (Olfactory receptor OR9-24)	OR1L8	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGR9	reviewed	OR1N2_HUMAN	Olfactory receptor 1N2 (Olfactory receptor OR9-23)	OR1N2	Homo sapiens (Human)	330	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGS0	reviewed	OR1N1_HUMAN	Olfactory receptor 1N1 (Olfactory receptor 1-26) (OR1-26) (Olfactory receptor 1N3) (Olfactory receptor OR9-22)	OR1N1 OR1N3	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGS1	reviewed	OR1J4_HUMAN	Olfactory receptor 1J4 (HTPCRX01) (Olfactory receptor OR9-21)	OR1J4	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGS3	reviewed	OR1J1_HUMAN	Olfactory receptor 1J1 (Olfactory receptor OR9-18)	OR1J1	Homo sapiens (Human)	322	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q8NGS4	reviewed	O13F1_HUMAN	Olfactory receptor 13F1 (Olfactory receptor OR9-6)	OR13F1	Homo sapiens (Human)	319	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGS5	reviewed	O13C4_HUMAN	Olfactory receptor 13C4 (Olfactory receptor OR9-7)	OR13C4	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGS6	reviewed	O13C3_HUMAN	Olfactory receptor 13C3 (Olfactory receptor OR9-8)	OR13C3	Homo sapiens (Human)	347	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGS7	reviewed	O13C8_HUMAN	Olfactory receptor 13C8	OR13C8	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGS9	reviewed	O13C2_HUMAN	Olfactory receptor 13C2 (Olfactory receptor OR9-12)	OR13C2	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGT1	reviewed	OR2K2_HUMAN	Olfactory receptor 2K2 (HTPCRH06) (Olfactory receptor OR9-17)	OR2K2 OR2AR1P	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGT2	reviewed	O13J1_HUMAN	Olfactory receptor 13J1 (Olfactory receptor OR9-2)	OR13J1	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGT5	reviewed	OR9A2_HUMAN	Olfactory receptor 9A2 (Olfactory receptor OR7-2)	OR9A2	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGT7	reviewed	O2A12_HUMAN	Olfactory receptor 2A12 (Olfactory receptor OR7-10)	OR2A12 OR2A12P	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGT9	reviewed	OR2A1_HUMAN	Olfactory receptor 2A1/2A42 (Olfactory receptor OR7-16) (Olfactory receptor OR7-19)	OR2A1; OR2A42	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGU1	reviewed	OR9A1_HUMAN	Olfactory receptor 9A1 (HSHTPRX06)	OR9A1P OR9A1	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGU2	reviewed	OR9A4_HUMAN	Olfactory receptor 9A4 (Olfactory receptor OR7-1)	OR9A4	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGU4	reviewed	OR2I1_HUMAN	Putative olfactory receptor 2I1 (Putative olfactory receptor 2I2) (Putative olfactory receptor 2I3) (Putative olfactory receptor 2I4)	OR2I1P OR2I2 OR2I3P OR2I4P	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGU9	reviewed	GP150_HUMAN	Probable G-protein coupled receptor 150	GPR150	Homo sapiens (Human)	434	FUNCTION: Orphan receptor.		cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGV0	reviewed	OR2Y1_HUMAN	Olfactory receptor 2Y1 (Olfactory receptor OR5-2)	OR2Y1	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGV5	reviewed	O13D1_HUMAN	Olfactory receptor 13D1 (Olfactory receptor OR9-15)	OR13D1	Homo sapiens (Human)	346	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGV7	reviewed	OR5H2_HUMAN	Olfactory receptor 5H2 (Olfactory receptor OR3-10)	OR5H2	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGX0	reviewed	O11L1_HUMAN	Olfactory receptor 11L1	OR11L1	Homo sapiens (Human)	322	FUNCTION: Odorant receptor. {ECO:0000305}.			extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGX1	reviewed	O2T34_HUMAN	Olfactory receptor 2T34 (Olfactory receptor OR1-63)	OR2T34	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGX2	reviewed	O2T35_HUMAN	Olfactory receptor 2T35 (Olfactory receptor OR1-66)	OR2T35	Homo sapiens (Human)	323	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGX5	reviewed	O10K1_HUMAN	Olfactory receptor 10K1 (Olfactory receptor OR1-6)	OR10K1	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGX6	reviewed	O10R2_HUMAN	Olfactory receptor 10R2 (Olfactory receptor OR1-8)	OR10R2	Homo sapiens (Human)	335	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGX8	reviewed	OR6Y1_HUMAN	Olfactory receptor 6Y1 (Olfactory receptor 6Y2) (Olfactory receptor OR1-11)	OR6Y1 OR6Y2	Homo sapiens (Human)	325	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGX9	reviewed	OR6P1_HUMAN	Olfactory receptor 6P1 (Olfactory receptor OR1-12)	OR6P1	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGY1	reviewed	O10Z1_HUMAN	Olfactory receptor 10Z1 (Olfactory receptor OR1-15)	OR10Z1	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGY2	reviewed	OR6K2_HUMAN	Olfactory receptor 6K2 (Olfactory receptor OR1-17)	OR6K2	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGY5	reviewed	OR6N1_HUMAN	Olfactory receptor 6N1	OR6N1	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGY6	reviewed	OR6N2_HUMAN	Olfactory receptor 6N2 (Olfactory receptor OR1-23)	OR6N2	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGY7	reviewed	O10J6_HUMAN	Putative olfactory receptor 10J6	OR10J6P OR10J6	Homo sapiens (Human)	276	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGY9	reviewed	OR2L8_HUMAN	Olfactory receptor 2L8 (Olfactory receptor OR1-46)	OR2L8	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGZ0	reviewed	O2AJ1_HUMAN	Olfactory receptor 2AJ1	OR2AJ1 OR2AJ1P	Homo sapiens (Human)	328	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGZ2	reviewed	O14K1_HUMAN	Olfactory receptor 14K1 (Olfactory receptor 5AY1) (Olfactory receptor OR1-39)	OR14K1 OR5AY1	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGZ3	reviewed	O13G1_HUMAN	Olfactory receptor 13G1 (Olfactory receptor OR1-37)	OR13G1	Homo sapiens (Human)	307	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGZ4	reviewed	OR2G3_HUMAN	Olfactory receptor 2G3 (Olfactory receptor OR1-33)	OR2G3	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGZ5	reviewed	OR2G2_HUMAN	Olfactory receptor 2G2 (Olfactory receptor OR1-32)	OR2G2	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGZ6	reviewed	OR6F1_HUMAN	Olfactory receptor 6F1 (Olfactory receptor OR1-38)	OR6F1	Homo sapiens (Human)	308	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NGZ9	reviewed	O2T10_HUMAN	Olfactory receptor 2T10 (Olfactory receptor OR1-64)	OR2T10	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH00	reviewed	OR2T4_HUMAN	Olfactory receptor 2T4 (Olfactory receptor OR1-60)	OR2T4	Homo sapiens (Human)	348	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH01	reviewed	O2T11_HUMAN	Olfactory receptor 2T11 (Olfactory receptor OR1-65)	OR2T11	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH02	reviewed	O2T29_HUMAN	Olfactory receptor 2T29	OR2T29	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH03	reviewed	OR2T3_HUMAN	Olfactory receptor 2T3	OR2T3	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH04	reviewed	O2T27_HUMAN	Olfactory receptor 2T27 (Olfactory receptor OR1-67)	OR2T27	Homo sapiens (Human)	317	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH05	reviewed	OR4Q3_HUMAN	Olfactory receptor 4Q3 (Olfactory receptor 4Q4) (Olfactory receptor OR14-3)	OR4Q3 C14orf13 OR4Q4	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH06	reviewed	OR1P1_HUMAN	Olfactory receptor 1P1 (Olfactory receptor 17-208) (OR17-208) (Olfactory receptor OR17-9)	OR1P1 OR1P1P	Homo sapiens (Human)	330	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH07	reviewed	O11H2_HUMAN	Olfactory receptor 11H2 (Olfactory receptor OR14-1)	OR11H2 C14orf15 OR11H2P	Homo sapiens (Human)	326	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NH08	reviewed	O10AC_HUMAN	Olfactory receptor 10AC1 (Olfactory receptor OR7-5)	OR10AC1 OR10AC1P	Homo sapiens (Human)	325	FUNCTION: Odorant receptor. {ECO:0000250}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NH09	reviewed	OR8S1_HUMAN	Olfactory receptor 8S1	OR8S1	Homo sapiens (Human)	359	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH16	reviewed	OR2L2_HUMAN	Olfactory receptor 2L2 (HTPCRH07) (Olfactory receptor 2L12) (Olfactory receptor 2L4)	OR2L2 OR2L12 OR2L4P	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH18	reviewed	OR5J2_HUMAN	Olfactory receptor 5J2 (Olfactory receptor OR11-266)	OR5J2	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH37	reviewed	OR4C3_HUMAN	Olfactory receptor 4C3 (Olfactory receptor OR11-98)	OR4C3	Homo sapiens (Human)	302	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH40	reviewed	OR6S1_HUMAN	Olfactory receptor 6S1 (Olfactory receptor OR14-37)	OR6S1	Homo sapiens (Human)	331	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH41	reviewed	OR4KF_HUMAN	Olfactory receptor 4K15 (Olfactory receptor OR14-20)	OR4K15	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH42	reviewed	OR4KD_HUMAN	Olfactory receptor 4K13 (Olfactory receptor OR14-27)	OR4K13	Homo sapiens (Human)	304	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH49	reviewed	OR4X1_HUMAN	Olfactory receptor 4X1 (Olfactory receptor OR11-104)	OR4X1	Homo sapiens (Human)	305	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH50	reviewed	OR8K5_HUMAN	Olfactory receptor 8K5 (Olfactory receptor OR11-174)	OR8K5	Homo sapiens (Human)	307	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH51	reviewed	OR8K3_HUMAN	Olfactory receptor 8K3 (Olfactory receptor OR11-181)	OR8K3	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH53	reviewed	O52N1_HUMAN	Olfactory receptor 52N1 (Olfactory receptor OR11-61)	OR52N1	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH54	reviewed	O56A3_HUMAN	Olfactory receptor 56A3 (Olfactory receptor 56A6)	OR56A3 OR56A3P OR56A6	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH55	reviewed	O52E5_HUMAN	Olfactory receptor 52E5	OR52E5	Homo sapiens (Human)	327	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH56	reviewed	O52N5_HUMAN	Olfactory receptor 52N5 (Olfactory receptor OR11-62)	OR52N5	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH57	reviewed	O52P1_HUMAN	Olfactory receptor 52P1	OR52P1 OR52P1P	Homo sapiens (Human)	321	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q8NH60	reviewed	O52J3_HUMAN	Olfactory receptor 52J3 (Olfactory receptor OR11-32)	OR52J3	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH61	reviewed	O51F2_HUMAN	Olfactory receptor 51F2 (Olfactory receptor OR11-23)	OR51F2	Homo sapiens (Human)	342	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH63	reviewed	O51H1_HUMAN	Olfactory receptor 51H1 (Olfactory receptor OR11-25)	OR51H1 OR51H1P	Homo sapiens (Human)	302	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH64	reviewed	O51A7_HUMAN	Olfactory receptor 51A7 (Olfactory receptor OR11-27)	OR51A7	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH67	reviewed	O52I2_HUMAN	Olfactory receptor 52I2 (Olfactory receptor OR11-12)	OR52I2	Homo sapiens (Human)	350	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH70	reviewed	O4A16_HUMAN	Olfactory receptor 4A16 (Olfactory receptor OR11-117)	OR4A16	Homo sapiens (Human)	328	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH72	reviewed	OR4C6_HUMAN	Olfactory receptor 4C6 (Olfactory receptor OR11-138)	OR4C6	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH73	reviewed	OR4S2_HUMAN	Olfactory receptor 4S2 (Olfactory receptor OR11-137)	OR4S2 OR4S2P	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH74	reviewed	O10A6_HUMAN	Olfactory receptor 10A6 (Olfactory receptor OR11-96)	OR10A6	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH76	reviewed	O56B4_HUMAN	Olfactory receptor 56B4 (Olfactory receptor OR11-67)	OR56B4	Homo sapiens (Human)	319	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH79	reviewed	OR6X1_HUMAN	Olfactory receptor 6X1 (Olfactory receptor OR11-270)	OR6X1	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH80	reviewed	O10D3_HUMAN	Olfactory receptor 10D3 (HTPCRX09) (Olfactory receptor OR11-293)	OR10D3 OR10D3P	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q8NH81	reviewed	O10G6_HUMAN	Olfactory receptor 10G6 (Olfactory receptor OR11-280)	OR10G6 OR10G6P	Homo sapiens (Human)	332	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH83	reviewed	OR4A5_HUMAN	Olfactory receptor 4A5 (Olfactory receptor OR11-111)	OR4A5	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH89	reviewed	O5AK3_HUMAN	Putative olfactory receptor 5AK3	OR5AK3P OR5AK3	Homo sapiens (Human)	298	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH90	reviewed	O5AK2_HUMAN	Olfactory receptor 5AK2	OR5AK2	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH93	reviewed	OR1L3_HUMAN	Olfactory receptor 1L3 (Olfactory receptor 9-D) (OR9-D) (Olfactory receptor OR9-28)	OR1L3	Homo sapiens (Human)	324	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NH95	reviewed	O13C6_HUMAN	Putative olfactory receptor 13C6 (Olfactory receptor, family 13, subfamily C, member 6 pseudogene) (Olfactory receptor, family 13, subfamily C, member 7 pseudogene) (Putative olfactory receptor 13C7)	OR13C6P	Homo sapiens (Human)	151	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHA4	reviewed	O2AE1_HUMAN	Olfactory receptor 2AE1 (Olfactory receptor 2AE2)	OR2AE1 OR2AE2	Homo sapiens (Human)	323	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHA6	reviewed	OR2W6_HUMAN	Putative olfactory receptor 2W6 (Olfactory receptor OR6-3) (Putative olfactory receptor 2W7)	OR2W6P OR2W7P	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHA8	reviewed	OR1FC_HUMAN	Putative olfactory receptor 1F12P (Hs6M1-35P)	OR1F12P OR1F12	Homo sapiens (Human)	337	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHB1	reviewed	OR2V1_HUMAN	Olfactory receptor 2V1	OR2V1	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHB7	reviewed	OR5K1_HUMAN	Olfactory receptor 5K1 (HTPCRX10) (Olfactory receptor OR3-8)	OR5K1	Homo sapiens (Human)	308	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHB8	reviewed	OR5K2_HUMAN	Olfactory receptor 5K2 (Olfactory receptor OR3-9)	OR5K2	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHC5	reviewed	O14AG_HUMAN	Olfactory receptor 14A16 (Olfactory receptor 5AT1) (Olfactory receptor OR1-45)	OR14A16 OR5AT1	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHC6	reviewed	O14L1_HUMAN	Olfactory receptor 14L1 (Olfactory receptor 5AV1)	OR14L1 OR14L1P OR5AV1P	Homo sapiens (Human)	325	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q8NHC7	reviewed	O14CZ_HUMAN	Olfactory receptor 14C36 (Olfactory receptor 5BF1) (Olfactory receptor OR1-59)	OR14C36 OR5BF1	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHR9	reviewed	PROF4_HUMAN	Profilin-4 (Profilin IV)	PFN4	Homo sapiens (Human)	129	FUNCTION: Involved in male fertility. Required for manchette development and acrosome biogenesis during spermiogenesis (By similarity). Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA) (PubMed:19419568). Contrary to other profilin family members, does not bind to actin in vitro (PubMed:19419568). {ECO:0000250|UniProtKB:Q9D6I3, ECO:0000269|PubMed:19419568}.		acrosome assembly [GO:0001675]; flagellated sperm motility [GO:0030317]; manchette assembly [GO:1905198]; sequestering of actin monomers [GO:0042989]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283]	cell cortex [GO:0005938]	actin monomer binding [GO:0003785]; lipid binding [GO:0008289]	cell cortex [GO:0005938]; actin monomer binding [GO:0003785]; lipid binding [GO:0008289]; acrosome assembly [GO:0001675]; flagellated sperm motility [GO:0030317]; manchette assembly [GO:1905198]; sequestering of actin monomers [GO:0042989]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19419568}. Note=In round spermatids, mainly observed in the acroplaxome. During the progression of spermiogenesis, relocalizes to the developing manchette of spermatids step 8 (S8). Coinciding with the initiation of manchette disassembly in spermatids S14, seen in the cytoplasm subjacent to the disassembling manchette. {ECO:0000269|PubMed:19419568}.
Q8NHS2	reviewed	AATC2_HUMAN	Putative aspartate aminotransferase, cytoplasmic 2 (EC 2.6.1.1) (Glutamate oxaloacetate transaminase 1-like protein 1) (Transaminase A-like protein 1)	GOT1L1	Homo sapiens (Human)	421		MISCELLANEOUS: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.	aspartate biosynthetic process [GO:0006532]	cytosol [GO:0005829]	L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; pyridoxal phosphate binding [GO:0030170]	cytosol [GO:0005829]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; pyridoxal phosphate binding [GO:0030170]; aspartate biosynthetic process [GO:0006532]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8NHS4	reviewed	CLHC1_HUMAN	Clathrin heavy chain linker domain-containing protein 1	CLHC1 C2orf63	Homo sapiens (Human)	586							
Q8NHU0	reviewed	CT453_HUMAN	Cancer/testis antigen family 45 member A3 (Cancer/testis antigen 45-3) (Cancer/testis antigen 45-4) (Cancer/testis antigen 45A3) (Cancer/testis antigen 45A4) (Cancer/testis antigen family 45 member A4)	CT45A3 CT45-3 CT45-4 CT45A4	Homo sapiens (Human)	189							
Q8NHV5	reviewed	MOSMO_HUMAN	Modulator of smoothened protein (Attenuator of hedgehog)	MOSMO ATTHOG C16orf52	Homo sapiens (Human)	167	FUNCTION: Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation. {ECO:0000250|UniProtKB:Q8C784}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell differentiation [GO:0030154]; negative regulation of smoothened signaling pathway [GO:0045879]; regulation of neuron differentiation [GO:0045664]; regulation of protein stability [GO:0031647]	ciliary membrane [GO:0060170]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]		ciliary membrane [GO:0060170]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; cell differentiation [GO:0030154]; negative regulation of smoothened signaling pathway [GO:0045879]; regulation of neuron differentiation [GO:0045664]; regulation of protein stability [GO:0031647]	SUBCELLULAR LOCATION: Cell projection, cilium membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8C784}. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8C784}.
Q8NHW5	reviewed	RLA0L_HUMAN	Putative ribosomal protein uL10-like (60S acidic ribosomal protein P0-like) (Large ribosomal subunit protein uL10-like)	RPLP0P6	Homo sapiens (Human)	317	FUNCTION: Ribosomal protein P0 is the functional equivalent of E.coli protein L10. {ECO:0000250}.		cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027]	cytosolic large ribosomal subunit [GO:0022625]	large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027]	
Q8NHW6	reviewed	OTOSP_HUMAN	Otospiralin	OTOS OTOSP	Homo sapiens (Human)	89	FUNCTION: May be essential for the survival of the neurosensory epithelium of the inner ear. {ECO:0000250}.		sensory perception of sound [GO:0007605]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8NHY5	reviewed	HUS1B_HUMAN	Checkpoint protein HUS1B (hHUS1B)	HUS1B	Homo sapiens (Human)	278			double-strand break repair via homologous recombination [GO:0000724]; meiotic DNA integrity checkpoint signaling [GO:0044778]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; nucleotide-excision repair [GO:0006289]; telomere maintenance [GO:0000723]	checkpoint clamp complex [GO:0030896]; nucleolus [GO:0005730]; site of double-strand break [GO:0035861]		checkpoint clamp complex [GO:0030896]; nucleolus [GO:0005730]; site of double-strand break [GO:0035861]; double-strand break repair via homologous recombination [GO:0000724]; meiotic DNA integrity checkpoint signaling [GO:0044778]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; nucleotide-excision repair [GO:0006289]; telomere maintenance [GO:0000723]	
Q8TA94	reviewed	ZN563_HUMAN	Zinc finger protein 563	ZNF563	Homo sapiens (Human)	476	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TAA1	reviewed	RNS11_HUMAN	Probable ribonuclease 11 (RNase 11) (EC 3.1.27.-)	RNASE11 C14orf6 UNQ5832/PRO19669	Homo sapiens (Human)	199			defense response to Gram-positive bacterium [GO:0050830]	extracellular region [GO:0005576]	endonuclease activity [GO:0004519]; nucleic acid binding [GO:0003676]	extracellular region [GO:0005576]; endonuclease activity [GO:0004519]; nucleic acid binding [GO:0003676]; defense response to Gram-positive bacterium [GO:0050830]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8TAI1	reviewed	TYMOS_HUMAN	TYMS opposite strand protein	TYMSOS C18orf56	Homo sapiens (Human)	123							
Q8TAV0	reviewed	FA76A_HUMAN	Protein FAM76A	FAM76A	Homo sapiens (Human)	307				nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]		nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	
Q8TAV5	reviewed	KC5S1_HUMAN	Uncharacterized protein KCNJ5-AS1 (KCNJ5 antisense RNA 1)	KCNJ5-AS1 C11orf45	Homo sapiens (Human)	145				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8TAW3	reviewed	ZN671_HUMAN	Zinc finger protein 671	ZNF671	Homo sapiens (Human)	534	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TB22	reviewed	SPT20_HUMAN	Spermatogenesis-associated protein 20 (Sperm-specific protein 411) (Ssp411)	SPATA20	Homo sapiens (Human)	786	FUNCTION: May play a role in fertility regulation. {ECO:0000250}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	carbohydrate metabolic process [GO:0005975]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; carbohydrate metabolic process [GO:0005975]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8TB69	reviewed	ZN519_HUMAN	Zinc finger protein 519	ZNF519	Homo sapiens (Human)	540	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TBF5	reviewed	PIGX_HUMAN	Phosphatidylinositol-glycan biosynthesis class X protein (PIG-X)	PIGX	Homo sapiens (Human)	258	FUNCTION: Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity). {ECO:0000250}.			endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q8TBF8	reviewed	FA81A_HUMAN	Protein FAM81A	FAM81A	Homo sapiens (Human)	368				glutamatergic synapse [GO:0098978]; postsynaptic density, intracellular component [GO:0099092]		glutamatergic synapse [GO:0098978]; postsynaptic density, intracellular component [GO:0099092]	
Q8TBP6	reviewed	S2540_HUMAN	Probable mitochondrial glutathione transporter SLC25A40 (Mitochondrial carrier family protein) (Solute carrier family 25 member 40)	SLC25A40 MCFP	Homo sapiens (Human)	338	FUNCTION: Probable mitochondrial transporter required for glutathione import into mitochondria (PubMed:34707288). Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (PubMed:34707288). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis (By similarity). {ECO:0000250|UniProtKB:Q8BGP6, ECO:0000269|PubMed:34707288}.		erythrocyte development [GO:0048821]; mitochondrial transmembrane transport [GO:1990542]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; erythrocyte development [GO:0048821]; mitochondrial transmembrane transport [GO:1990542]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein {ECO:0000255}.
Q8TBR7	reviewed	TLC3A_HUMAN	TLC domain-containing protein 3A (Protein CT120) (Protein FAM57A)	TLCD3A FAM57A	Homo sapiens (Human)	257			lipid homeostasis [GO:0055088]	endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]		endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; lipid homeostasis [GO:0055088]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8TC17	reviewed	GRAPL_HUMAN	GRB2-related adapter protein-like	GRAPL	Homo sapiens (Human)	118			cell migration [GO:0016477]; signal transduction [GO:0007165]	cytosol [GO:0005829]	receptor tyrosine kinase binding [GO:0030971]; signaling adaptor activity [GO:0035591]	cytosol [GO:0005829]; receptor tyrosine kinase binding [GO:0030971]; signaling adaptor activity [GO:0035591]; cell migration [GO:0016477]; signal transduction [GO:0007165]	
Q8TC90	reviewed	CCER1_HUMAN	Coiled-coil domain-containing glutamate-rich protein 1	CCER1 C12orf12	Homo sapiens (Human)	406							
Q8TCB0	reviewed	IFI44_HUMAN	Interferon-induced protein 44 (p44) (Microtubule-associated protein 44)	IFI44 MTAP44	Homo sapiens (Human)	444	FUNCTION: This protein aggregates to form microtubular structures. {ECO:0000250}.		immune response [GO:0006955]; response to bacterium [GO:0009617]; response to virus [GO:0009615]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; immune response [GO:0006955]; response to bacterium [GO:0009617]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8TCN5	reviewed	ZN507_HUMAN	Zinc finger protein 507	ZNF507 KIAA1084	Homo sapiens (Human)	953	FUNCTION: May be involved in transcriptional regulation.		positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TCP9	reviewed	F200A_HUMAN	Protein FAM200A	FAM200A C7orf38	Homo sapiens (Human)	573				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8TD55	reviewed	PKHO2_HUMAN	Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1)	PLEKHO2 PLEKHQ1 PP9099	Homo sapiens (Human)	490			macrophage apoptotic process [GO:0071888]	extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]		extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; macrophage apoptotic process [GO:0071888]	
Q8TD86	reviewed	CALL6_HUMAN	Calmodulin-like protein 6 (Calglandulin-like protein)	CALML6 CAGLP CALGP	Homo sapiens (Human)	181				cytoplasm [GO:0005737]; nucleus [GO:0005634]	calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15621662}. Nucleus {ECO:0000269|PubMed:15621662}.
Q8TDS7	reviewed	MRGRD_HUMAN	Mas-related G-protein coupled receptor member D (Beta-alanine receptor) (G-protein coupled receptor TGR7)	MRGPRD MRGD	Homo sapiens (Human)	321	FUNCTION: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).		G protein-coupled receptor signaling pathway [GO:0007186]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	extracellular space [GO:0005615]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15037633}; Multi-pass membrane protein {ECO:0000269|PubMed:15037633}. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
Q8TDU5	reviewed	VNRL4_HUMAN	Putative vomeronasal receptor-like protein 4 (G-protein coupled receptor GPCR23) (hGPCR23)	VN1R17P VNRL4	Homo sapiens (Human)	208	FUNCTION: Putative pheromone receptor. {ECO:0000250}.		response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606]	plasma membrane [GO:0005886]	pheromone receptor activity [GO:0016503]	plasma membrane [GO:0005886]; pheromone receptor activity [GO:0016503]; response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8TE96	reviewed	DQX1_HUMAN	ATP-dependent RNA helicase DQX1 (EC 3.6.4.12) (DEAQ box polypeptide 1)	DQX1	Homo sapiens (Human)	717				spliceosomal complex [GO:0005681]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]	spliceosomal complex [GO:0005681]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8TEE9	reviewed	SAP25_HUMAN	Histone deacetylase complex subunit SAP25 (25 kDa Sin3-associated polypeptide) (Sin3 corepressor complex subunit SAP25)	SAP25	Homo sapiens (Human)	199	FUNCTION: Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex. {ECO:0000250}.		regulation of DNA-templated transcription [GO:0006355]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
Q8TEQ0	reviewed	SNX29_HUMAN	Sorting nexin-29 (RUN domain-containing protein 2A)	SNX29 RUNDC2A	Homo sapiens (Human)	813					phosphatidylinositol binding [GO:0035091]	phosphatidylinositol binding [GO:0035091]	
Q8TF08	reviewed	CX7B2_HUMAN	Cytochrome c oxidase subunit 7B2, mitochondrial (Cytochrome c oxidase polypeptide VIIb2)	COX7B2	Homo sapiens (Human)	81	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P13183}.		mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; spermatogenesis [GO:0007283]	mitochondrial respirasome [GO:0005746]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]		mitochondrial respirasome [GO:0005746]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P13183}; Single-pass membrane protein {ECO:0000250|UniProtKB:P13183}.
Q8TF20	reviewed	ZN721_HUMAN	Zinc finger protein 721	ZNF721 KIAA1982	Homo sapiens (Human)	911	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q8TF27	reviewed	AGA11_HUMAN	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11 (AGAP-11) (Centaurin-gamma-like protein KIAA1975)	AGAP11 KIAA1975	Homo sapiens (Human)	550	FUNCTION: Putative GTPase-activating protein. {ECO:0000305}.				GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	
Q8TF32	reviewed	ZN431_HUMAN	Zinc finger protein 431	ZNF431 KIAA1969	Homo sapiens (Human)	576	FUNCTION: Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q8TF44	reviewed	C2C4C_HUMAN	C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C)	C2CD4C FAM148C KIAA1957 NLF3	Homo sapiens (Human)	421				cytosol [GO:0005829]		cytosol [GO:0005829]	
Q8TF61	reviewed	FBX41_HUMAN	F-box only protein 41	FBXO41 FBX41 KIAA1940	Homo sapiens (Human)	875	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.			cytosol [GO:0005829]		cytosol [GO:0005829]	
Q8WTP9	reviewed	XAGE3_HUMAN	X antigen family member 3 (XAGE-3) (Cancer/testis antigen 12.3) (CT12.3) (G antigen family D member 4) (Placenta-specific gene 6 protein)	XAGE3 GAGED4 PLAC6 PP9012	Homo sapiens (Human)	111							
Q8WTR8	reviewed	NET5_HUMAN	Netrin-5 (Netrin-1-like protein)	NTN5	Homo sapiens (Human)	489	FUNCTION: Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. {ECO:0000250|UniProtKB:Q3UQ22}.		neurogenesis [GO:0022008]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; neurogenesis [GO:0022008]	SUBCELLULAR LOCATION: Secreted {ECO:0000255}.
Q8WTU2	reviewed	SRB4D_HUMAN	Scavenger receptor cysteine-rich domain-containing group B protein (Four scavenger receptor cysteine-rich domains-containing protein) (S4D-SRCRB)	SSC4D SRCRB4D	Homo sapiens (Human)	575		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		extracellular region [GO:0005576]; membrane [GO:0016020]		extracellular region [GO:0005576]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8WU76	reviewed	SCFD2_HUMAN	Sec1 family domain-containing protein 2 (Syntaxin-binding protein 1-like 1)	SCFD2 STXBP1L1	Homo sapiens (Human)	684	FUNCTION: May be involved in protein transport.		intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]			intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	
Q8WUH6	reviewed	TM263_HUMAN	Transmembrane protein 263	TMEM263 C12orf23	Homo sapiens (Human)	116	FUNCTION: May play a role in bone development. {ECO:0000269|PubMed:34238371}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q8WUS8	reviewed	D42E1_HUMAN	Short-chain dehydrogenase/reductase family 42E member 1 (EC 1.1.1.-)	SDR42E1 HSPC105	Homo sapiens (Human)	393			steroid biosynthetic process [GO:0006694]	membrane [GO:0016020]	3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	membrane [GO:0016020]; 3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid biosynthetic process [GO:0006694]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8WUT9	reviewed	S2543_HUMAN	Solute carrier family 25 member 43	SLC25A43	Homo sapiens (Human)	341			transmembrane transport [GO:0055085]	mitochondrial inner membrane [GO:0005743]		mitochondrial inner membrane [GO:0005743]; transmembrane transport [GO:0055085]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q8WUY8	reviewed	NAT14_HUMAN	Probable N-acetyltransferase 14 (EC 2.3.1.-) (K562 cell-derived leucine-zipper-like protein 1)	NAT14 KLP1	Homo sapiens (Human)	206	FUNCTION: Probable acetyltransferase. {ECO:0000305}.; FUNCTION: May act as a transcription factor that regulates the expression of coproporphyrinogen oxidase by binding to a promoter regulatory element. {ECO:0000269|PubMed:10873651}.		DNA-templated transcription initiation [GO:0006352]; positive regulation of DNA-templated transcription [GO:0045893]	membrane [GO:0016020]; nucleus [GO:0005634]	DNA binding [GO:0003677]; N-acetyltransferase activity [GO:0008080]	membrane [GO:0016020]; nucleus [GO:0005634]; DNA binding [GO:0003677]; N-acetyltransferase activity [GO:0008080]; DNA-templated transcription initiation [GO:0006352]; positive regulation of DNA-templated transcription [GO:0045893]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8WUY9	reviewed	DEP1B_HUMAN	DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8)	DEPDC1B XTP8	Homo sapiens (Human)	529			cell migration [GO:0016477]; intracellular signal transduction [GO:0035556]; positive regulation of Wnt signaling pathway [GO:0030177]		GTPase activator activity [GO:0005096]	GTPase activator activity [GO:0005096]; cell migration [GO:0016477]; intracellular signal transduction [GO:0035556]; positive regulation of Wnt signaling pathway [GO:0030177]	
Q8WV15	reviewed	T255B_HUMAN	Transmembrane protein 255B (Protein FAM70B)	TMEM255B FAM70B	Homo sapiens (Human)	326				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8WV83	reviewed	S35F5_HUMAN	Solute carrier family 35 member F5 (Hepatitis C virus NS5A-transactivated protein 3) (HCV NS5A-transactivated protein 3)	SLC35F5 NS5ATP3 UNQ2545/PRO6097	Homo sapiens (Human)	523	FUNCTION: Putative solute transporter. {ECO:0000305}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8WVC6	reviewed	DCAKD_HUMAN	Dephospho-CoA kinase domain-containing protein	DCAKD	Homo sapiens (Human)	231			coenzyme A biosynthetic process [GO:0015937]	membrane [GO:0016020]	ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140]	membrane [GO:0016020]; ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140]; coenzyme A biosynthetic process [GO:0015937]	
Q8WVE6	reviewed	TM171_HUMAN	Transmembrane protein 171	TMEM171	Homo sapiens (Human)	324				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8WVF2	reviewed	UCMA_HUMAN	Unique cartilage matrix-associated protein [Cleaved into: Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C) (Gla-rich protein) (GRP)]	UCMA C10orf49	Homo sapiens (Human)	138	FUNCTION: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. {ECO:0000250}.		embryonic skeletal system development [GO:0048706]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of SMAD protein signal transduction [GO:0060392]; osteoblast differentiation [GO:0001649]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	BMP binding [GO:0036122]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; BMP binding [GO:0036122]; embryonic skeletal system development [GO:0048706]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of SMAD protein signal transduction [GO:0060392]; osteoblast differentiation [GO:0001649]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q8WVI7	reviewed	PPR1C_HUMAN	Protein phosphatase 1 regulatory subunit 1C (Inhibitor-5 of protein phosphatase 1) (IPP5)	PPP1R1C	Homo sapiens (Human)	109	FUNCTION: May increase cell susceptibility to TNF-induced apoptosis. {ECO:0000269|PubMed:19874272}.		cell cycle [GO:0007049]; cell division [GO:0051301]; intracellular signal transduction [GO:0035556]	cytoplasm [GO:0005737]	protein phosphatase inhibitor activity [GO:0004864]	cytoplasm [GO:0005737]; protein phosphatase inhibitor activity [GO:0004864]; cell cycle [GO:0007049]; cell division [GO:0051301]; intracellular signal transduction [GO:0035556]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8WW18	reviewed	CQ050_HUMAN	Uncharacterized protein C17orf50	C17orf50	Homo sapiens (Human)	174							
Q8WW32	reviewed	HMGB4_HUMAN	High mobility group protein B4	HMGB4	Homo sapiens (Human)	186			regulation of transcription by RNA polymerase II [GO:0006357]	chromosome [GO:0005694]; nucleus [GO:0005634]	DNA binding, bending [GO:0008301]	chromosome [GO:0005694]; nucleus [GO:0005634]; DNA binding, bending [GO:0008301]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6P8W9}. Chromosome {ECO:0000250|UniProtKB:Q6P8W9}. Note=Interacts specifically with the sex chromosomes. {ECO:0000250|UniProtKB:Q6P8W9}.
Q8WW33	reviewed	GTSF1_HUMAN	Gametocyte-specific factor 1 (Protein FAM112B)	GTSF1 FAM112B	Homo sapiens (Human)	167	FUNCTION: Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells. {ECO:0000250|UniProtKB:Q9DAN6}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]	metal ion binding [GO:0046872]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; tRNA binding [GO:0000049]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9DAN6}.
Q8WW36	reviewed	ZCH13_HUMAN	Zinc finger CCHC domain-containing protein 13	ZCCHC13	Homo sapiens (Human)	166			positive regulation of cytoplasmic translation [GO:2000767]	cytoplasm [GO:0005737]	mRNA binding [GO:0003729]; single-stranded RNA binding [GO:0003727]; translation regulator activity [GO:0045182]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; mRNA binding [GO:0003729]; single-stranded RNA binding [GO:0003727]; translation regulator activity [GO:0045182]; zinc ion binding [GO:0008270]; positive regulation of cytoplasmic translation [GO:2000767]	
Q8WW52	reviewed	F151A_HUMAN	Protein FAM151A	FAM151A C1orf179 UNQ3034/PRO9836	Homo sapiens (Human)	585				extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8WW62	reviewed	TMED6_HUMAN	Transmembrane emp24 domain-containing protein 6 (p24 family protein gamma-5) (p24gamma5)	TMED6 UNQ9146/PRO34237	Homo sapiens (Human)	240			endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]		COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q8WWA1	reviewed	TMM40_HUMAN	Transmembrane protein 40	TMEM40	Homo sapiens (Human)	233				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|Ref.6}; Multi-pass membrane protein {ECO:0000269|Ref.6}.
Q8WWU7	reviewed	ITLN2_HUMAN	Intelectin-2 (Endothelial lectin HL-2)	ITLN2 UNQ2789/PRO7179	Homo sapiens (Human)	325	FUNCTION: May play a role in the defense system against pathogens. {ECO:0000250}.			extracellular space [GO:0005615]	metal ion binding [GO:0046872]; oligosaccharide binding [GO:0070492]	extracellular space [GO:0005615]; metal ion binding [GO:0046872]; oligosaccharide binding [GO:0070492]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8WWX0	reviewed	ASB5_HUMAN	Ankyrin repeat and SOCS box protein 5 (ASB-5)	ASB5	Homo sapiens (Human)	329	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity). {ECO:0000250}.		intracellular signal transduction [GO:0035556]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]		cytosol [GO:0005829]; intracellular signal transduction [GO:0035556]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]	
Q8WX39	reviewed	LCN9_HUMAN	Epididymal-specific lipocalin-9 (MUP-like lipocalin)	LCN9	Homo sapiens (Human)	176				extracellular space [GO:0005615]	small molecule binding [GO:0036094]	extracellular space [GO:0005615]; small molecule binding [GO:0036094]	SUBCELLULAR LOCATION: Secreted.
Q8WXE0	reviewed	CSKI2_HUMAN	Caskin-2 (CASK-interacting protein 2)	CASKIN2 KIAA1139	Homo sapiens (Human)	1202				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q8WXF5	reviewed	CRGN_HUMAN	Gamma-crystallin N (Gamma-N-crystallin)	CRYGN	Homo sapiens (Human)	182			lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]		structural constituent of eye lens [GO:0005212]	structural constituent of eye lens [GO:0005212]; lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]	
Q8WXJ9	reviewed	ASB17_HUMAN	Ankyrin repeat and SOCS box protein 17 (ASB-17)	ASB17	Homo sapiens (Human)	295	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]		cytosol [GO:0005829]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	
Q8WXS4	reviewed	CCGL_HUMAN	Voltage-dependent calcium channel gamma-like subunit (Neuronal voltage-gated calcium channel gamma-like subunit) (Transmembrane protein 37)	TMEM37 PR	Homo sapiens (Human)	190	FUNCTION: Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity). {ECO:0000250|UniProtKB:Q9JJV3}.		regulation of monoatomic ion transmembrane transport [GO:0034765]	membrane [GO:0016020]	calcium channel activity [GO:0005262]; voltage-gated monoatomic ion channel activity [GO:0005244]	membrane [GO:0016020]; calcium channel activity [GO:0005262]; voltage-gated monoatomic ion channel activity [GO:0005244]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8WXT5	reviewed	FX4L4_HUMAN	Forkhead box protein D4-like 4 (FOXD4-like 4) (Forkhead box protein D4-like 2) (Forkhead box protein D4B) (Myeloid factor-gamma)	FOXD4L4 FOXD4B FOXD4L2	Homo sapiens (Human)	416			anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Q8WYK1	reviewed	CNTP5_HUMAN	Contactin-associated protein-like 5 (Cell recognition molecule Caspr5)	CNTNAP5 CASPR5	Homo sapiens (Human)	1306	FUNCTION: May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.		cell adhesion [GO:0007155]	membrane [GO:0016020]		membrane [GO:0016020]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8WZ33	reviewed	MAFIP_HUMAN	MaFF-interacting protein (Tektin-4 like protein PP5644)	MAFIP MIP PP5644	Homo sapiens (Human)	124	FUNCTION: Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency. {ECO:0000269|PubMed:15881666, ECO:0000269|PubMed:16549056}.		cilium movement involved in cell motility [GO:0060294]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]		cytoplasm [GO:0005737]; nucleolus [GO:0005730]; cilium movement involved in cell motility [GO:0060294]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16549056}. Nucleus, nucleolus {ECO:0000269|PubMed:16549056}. Note=Interaction with MAFF induces its translocation from the cytoplasm to the nucleolus.
Q8WZ71	reviewed	TM158_HUMAN	Transmembrane protein 158 (40 kDa BINP-binding protein) (p40BBP) (Ras-induced senescence protein 1)	TMEM158 HBBP RIS1	Homo sapiens (Human)	300	FUNCTION: Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide. {ECO:0000250}.			membrane [GO:0016020]	peptide binding [GO:0042277]	membrane [GO:0016020]; peptide binding [GO:0042277]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8WZ82	reviewed	OVCA2_HUMAN	Esterase OVCA2 (EC 3.1.2.-) (Ovarian cancer-associated gene 2 protein)	OVCA2	Homo sapiens (Human)	227			response to retinoic acid [GO:0032526]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	hydrolase activity [GO:0016787]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; hydrolase activity [GO:0016787]; response to retinoic acid [GO:0032526]	
Q8WZ92	reviewed	OR5P2_HUMAN	Olfactory receptor 5P2 (Olfactory receptor-like protein JCG3)	OR5P2	Homo sapiens (Human)	322	FUNCTION: Odorant receptor (Potential). May be involved in taste perception. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8WZA0	reviewed	LZIC_HUMAN	Protein LZIC (Leucine zipper and CTNNBIP1 domain-containing protein) (Leucine zipper and ICAT homologous domain-containing protein)	LZIC	Homo sapiens (Human)	190			negative regulation of Wnt signaling pathway [GO:0030178]		beta-catenin binding [GO:0008013]	beta-catenin binding [GO:0008013]; negative regulation of Wnt signaling pathway [GO:0030178]	
Q8WZA6	reviewed	OR1E3_HUMAN	Olfactory receptor 1E3 (Olfactory receptor 17-210) (OR17-210) (Olfactory receptor OR17-7)	OR1E3 OR1E3P	Homo sapiens (Human)	343	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q92527	reviewed	ANKR7_HUMAN	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806)	ANKRD7	Homo sapiens (Human)	254				centrosome [GO:0005813]; nucleoplasm [GO:0005654]		centrosome [GO:0005813]; nucleoplasm [GO:0005654]	
Q92545	reviewed	TM131_HUMAN	Transmembrane protein 131 (Protein RW1)	TMEM131 KIAA0257 RW1	Homo sapiens (Human)	1883	FUNCTION: May play a role in the immune response to viral infection. {ECO:0000250}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q92576	reviewed	PHF3_HUMAN	PHD finger protein 3	PHF3 KIAA0244	Homo sapiens (Human)	2039			DNA-templated transcription [GO:0006351]	nucleus [GO:0005634]	metal ion binding [GO:0046872]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; DNA-templated transcription [GO:0006351]	
Q92670	reviewed	ZN75C_HUMAN	Putative zinc finger protein 75C (Zinc finger protein 75C pseudogene)	ZNF75CP ZNF75C	Homo sapiens (Human)	426	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q93075	reviewed	TATD2_HUMAN	Putative deoxyribonuclease TATDN2 (EC 3.1.21.-)	TATDN2 KIAA0218	Homo sapiens (Human)	761	FUNCTION: Putative deoxyribonuclease. {ECO:0000250}.			nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; nuclease activity [GO:0004518]	nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q93083	reviewed	MT1L_HUMAN	Metallothionein-1L (MT-1L) (Metallothionein-IL) (MT-IL)	MT1L	Homo sapiens (Human)	61	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. {ECO:0000250}.		cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]	
Q969E1	reviewed	LEAP2_HUMAN	Liver-expressed antimicrobial peptide 2 (LEAP-2)	LEAP2	Homo sapiens (Human)	77	FUNCTION: Has an antimicrobial activity. {ECO:0000269|PubMed:20845358}.		antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to bacterium [GO:0042742]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to bacterium [GO:0042742]	SUBCELLULAR LOCATION: Secreted.
Q969W3	reviewed	F104A_HUMAN	Protein FAM104A	FAM104A	Homo sapiens (Human)	186							
Q969Y0	reviewed	NXPE3_HUMAN	NXPE family member 3 (Protein FAM55C)	NXPE3 FAM55C MSTP115 UNQ5791/PRO19596	Homo sapiens (Human)	559				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96A98	reviewed	TIP39_HUMAN	Tuberoinfundibular peptide of 39 residues (TIP39) (Parathyroid hormone 2)	PTH2 TIP39 TIPF39	Homo sapiens (Human)	100	FUNCTION: Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. {ECO:0000269|PubMed:11861531, ECO:0000269|PubMed:12559132, ECO:0000269|PubMed:12754053, ECO:0000269|PubMed:14988434}.		neuropeptide signaling pathway [GO:0007218]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Secreted.
Q96AB3	reviewed	ISOC2_HUMAN	Isochorismatase domain-containing protein 2	ISOC2	Homo sapiens (Human)	205			protein destabilization [GO:0031648]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein destabilization [GO:0031648]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17658461}. Nucleus {ECO:0000269|PubMed:17658461}. Note=Localizes to the nucleus in the presence of CDKN2A.
Q96AQ9	reviewed	F131C_HUMAN	Protein FAM131C	FAM131C C1orf117	Homo sapiens (Human)	280							
Q96B33	reviewed	CLD23_HUMAN	Claudin-23	CLDN23	Homo sapiens (Human)	292	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.		bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q96B45	reviewed	BORC7_HUMAN	BLOC-1-related complex subunit 7 (Diaskedin)	BORCS7 C10orf32	Homo sapiens (Human)	106	FUNCTION: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000305|PubMed:25898167}.	MISCELLANEOUS: Diaskedin is from the ancient Greek diaskedazo, meaning to disperse. {ECO:0000303|PubMed:25898167}.	lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]	BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]		BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000305|PubMed:25898167}.
Q96BJ8	reviewed	ELMO3_HUMAN	Engulfment and cell motility protein 3	ELMO3	Homo sapiens (Human)	720	FUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). {ECO:0000250}.		actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell motility [GO:0048870]; phagocytosis [GO:0006909]	cytoplasm [GO:0005737]	SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; SH3 domain binding [GO:0017124]; actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell motility [GO:0048870]; phagocytosis [GO:0006909]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96BM0	reviewed	I27L1_HUMAN	Interferon alpha-inducible protein 27-like protein 1 (Interferon-stimulated gene 12c protein) (ISG12(c)) (ISG12C)	IFI27L1 FAM14B	Homo sapiens (Human)	104	FUNCTION: Plays a role in the apoptotic process and has a pro-apoptotic activity. {ECO:0000269|PubMed:27673746}.		apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]	membrane [GO:0016020]; mitochondrion [GO:0005739]		membrane [GO:0016020]; mitochondrion [GO:0005739]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q96BQ1	reviewed	FAM3D_HUMAN	Protein FAM3D	FAM3D UNQ567/PRO1130	Homo sapiens (Human)	224			negative regulation of insulin secretion [GO:0046676]	extracellular region [GO:0005576]; extracellular space [GO:0005615]	cytokine activity [GO:0005125]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; negative regulation of insulin secretion [GO:0046676]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96BW5	reviewed	PTER_HUMAN	Phosphotriesterase-related protein (EC 3.1.-.-) (Parathion hydrolase-related protein) (hPHRP)	PTER	Homo sapiens (Human)	349			catabolic process [GO:0009056]; epithelial cell differentiation [GO:0030855]	extracellular exosome [GO:0070062]	hydrolase activity, acting on ester bonds [GO:0016788]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; hydrolase activity, acting on ester bonds [GO:0016788]; zinc ion binding [GO:0008270]; catabolic process [GO:0009056]; epithelial cell differentiation [GO:0030855]	
Q96BX8	reviewed	MOB3A_HUMAN	MOB kinase activator 3A (MOB-LAK) (Mob1 homolog 2A) (Mps one binder kinase activator-like 2A)	MOB3A MOBKL2A	Homo sapiens (Human)	217	FUNCTION: May regulate the activity of kinases. {ECO:0000250}.		positive regulation of protein phosphorylation [GO:0001934]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; positive regulation of protein phosphorylation [GO:0001934]; signal transduction [GO:0007165]	
Q96C01	reviewed	F136A_HUMAN	Protein FAM136A	FAM136A	Homo sapiens (Human)	138				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q96C34	reviewed	RUND1_HUMAN	RUN domain-containing protein 1	RUNDC1 LP5161	Homo sapiens (Human)	613	FUNCTION: May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. {ECO:0000269|PubMed:16929179}.		in utero embryonic development [GO:0001701]			in utero embryonic development [GO:0001701]	
Q96C57	reviewed	CSTOS_HUMAN	Protein CUSTOS	CUSTOS C12orf43	Homo sapiens (Human)	262	FUNCTION: Plays a role in the regulation of Wnt signaling pathway during early development. {ECO:0000250|UniProtKB:A9C3N6}.		negative regulation of Wnt signaling pathway [GO:0030178]; Spemann organizer formation [GO:0060061]; Wnt signaling pathway [GO:0016055]	nuclear envelope [GO:0005635]		nuclear envelope [GO:0005635]; negative regulation of Wnt signaling pathway [GO:0030178]; Spemann organizer formation [GO:0060061]; Wnt signaling pathway [GO:0016055]	SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000250|UniProtKB:A9C3N6}.
Q96C90	reviewed	PP14B_HUMAN	Protein phosphatase 1 regulatory subunit 14B (Phospholipase C-beta-3 neighbouring gene protein)	PPP1R14B PLCB3N PNG	Homo sapiens (Human)	147	FUNCTION: Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). {ECO:0000250}.		innate immune response [GO:0045087]; regulation of phosphorylation [GO:0042325]	cytoplasm [GO:0005737]	protein serine/threonine phosphatase inhibitor activity [GO:0004865]	cytoplasm [GO:0005737]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; innate immune response [GO:0045087]; regulation of phosphorylation [GO:0042325]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q96CD0	reviewed	FBXL8_HUMAN	F-box/LRR-repeat protein 8 (F-box and leucine-rich repeat protein 8) (F-box protein FBL8)	FBXL8 FBL8	Homo sapiens (Human)	374	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.		SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]		cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	
Q96CH1	reviewed	GP146_HUMAN	Probable G-protein coupled receptor 146 (G-protein coupled receptor PGR8)	GPR146 PGR8	Homo sapiens (Human)	333	FUNCTION: Orphan receptor.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96CS4	reviewed	ZN689_HUMAN	Zinc finger protein 689	ZNF689	Homo sapiens (Human)	500	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96CT2	reviewed	KLH29_HUMAN	Kelch-like protein 29 (Kelch repeat and BTB domain-containing protein 9)	KLHL29 KBTBD9 KIAA1921	Homo sapiens (Human)	875							
Q96DC7	reviewed	TMCO6_HUMAN	Transmembrane and coiled-coil domain-containing protein 6	TMCO6 PRO1580	Homo sapiens (Human)	493			protein import into nucleus [GO:0006606]	membrane [GO:0016020]	nuclear import signal receptor activity [GO:0061608]	membrane [GO:0016020]; nuclear import signal receptor activity [GO:0061608]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96DD0	reviewed	LRC39_HUMAN	Leucine-rich repeat-containing protein 39 (Myosin-interacting M-band-associated stress-responsive protein) (Myomasp)	LRRC39 UNQ6500/PRO21368	Homo sapiens (Human)	335	FUNCTION: Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart. {ECO:0000250|UniProtKB:D3ZXS4}.		signal transduction [GO:0007165]	M band [GO:0031430]		M band [GO:0031430]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:D3ZXS4}.
Q96DL1	reviewed	NXPE2_HUMAN	NXPE family member 2 (Protein FAM55B)	NXPE2 FAM55B	Homo sapiens (Human)	559		MISCELLANEOUS: [Isoform 1]: Gene prediction based on EST data and similarity to mouse ortholog.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96DS6	reviewed	M4A6E_HUMAN	Membrane-spanning 4-domains subfamily A member 6E	MS4A6E	Homo sapiens (Human)	147	FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex.		cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]		plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q96DU9	reviewed	PABP5_HUMAN	Polyadenylate-binding protein 5 (PABP-5) (Poly(A)-binding protein 5)	PABPC5 PABP5	Homo sapiens (Human)	382	FUNCTION: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250}.			cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion matrix {ECO:0000269|PubMed:23275553}. Note=Co-fractionates with mtDNA and co-immunoprecipitates with the mitochondrial poly(A) polymerase.
Q96DY2	reviewed	DRC10_HUMAN	Dynein regulatory complex protein 10 (IQ domain-containing protein D)	IQCD DRC10	Homo sapiens (Human)	449	FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. {ECO:0000250|UniProtKB:A8J0N6}.			ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]		ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8J0N6}.
Q96E16	reviewed	SMI19_HUMAN	Small integral membrane protein 19	SMIM19 C8orf40	Homo sapiens (Human)	107				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96E39	reviewed	RMXL1_HUMAN	RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)	RBMXL1	Homo sapiens (Human)	390	FUNCTION: RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.	MISCELLANEOUS: According to some authors, RBMXL1 is a RBMX retrogene on chromosome X which is likely to be functional. {ECO:0000305|PubMed:16201836}.	mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]	spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96E66	reviewed	LRC51_HUMAN	Leucine-rich repeat-containing protein 51 (Protein LRTOMT1)	LRRC51 LRTOMT	Homo sapiens (Human)	192		MISCELLANEOUS: LRRC51 and TOMT were originally considered as alternative reading frames, LRTOMT1 and LRTOMT2 of the same LRTOMT gene in primates. {ECO:0000303|PubMed:18953341}.; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96EH5	reviewed	RL39L_HUMAN	Ribosomal protein eL39-like 2 (60S ribosomal protein L39-2) (60S ribosomal protein L39-like) (Large ribosomal subunit protein eL39-like)	RPL39L RPL39L1	Homo sapiens (Human)	51	FUNCTION: Male germ cell-specific component of the ribosome, which is required for the formation of sperm and male fertility. Replaces the RPL39 paralog in the ribosome of male germ cells. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The male germ cell-specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome. It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm. {ECO:0000250|UniProtKB:Q9CQD0}.		spermatogenesis [GO:0007283]; translation [GO:0006412]	cytosolic large ribosomal subunit [GO:0022625]	structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]; structural constituent of ribosome [GO:0003735]; spermatogenesis [GO:0007283]; translation [GO:0006412]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9CQD0}.
Q96EI5	reviewed	TCAL4_HUMAN	Transcription elongation factor A protein-like 4 (TCEA-like protein 4) (Transcription elongation factor S-II protein-like 4)	TCEAL4 NPD017	Homo sapiens (Human)	215	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96EK2	reviewed	PF21B_HUMAN	PHD finger protein 21B	PHF21B KIAA1661	Homo sapiens (Human)	531					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q96EL2	reviewed	RT24_HUMAN	Small ribosomal subunit protein uS3m (28S ribosomal protein S24, mitochondrial) (MRP-S24) (S24mt) (bMRP-47) (bMRP47)	MRPS24 HSPC335	Homo sapiens (Human)	167			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
Q96ER3	reviewed	SAAL1_HUMAN	Protein SAAL1 (Synoviocyte proliferation-associated in collagen-induced arthritis protein 1) (SPACIA1)	SAAL1	Homo sapiens (Human)	474	FUNCTION: Plays a role in promoting the proliferation of synovial fibroblasts in response to pro-inflammatory stimuli. {ECO:0000269|PubMed:22127701}.		positive regulation of synoviocyte proliferation [GO:1901647]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]; positive regulation of synoviocyte proliferation [GO:1901647]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22127701}.
Q96ES6	reviewed	MFSD3_HUMAN	Major facilitator superfamily domain-containing protein 3	MFSD3	Homo sapiens (Human)	412				membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96ET8	reviewed	TV23C_HUMAN	Golgi apparatus membrane protein TVP23 homolog C	TVP23C FAM18B2 Nbla10383	Homo sapiens (Human)	276			protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]	membrane [GO:0016020]		membrane [GO:0016020]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96EV2	reviewed	RBM33_HUMAN	RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33)	RBM33 PRR8	Homo sapiens (Human)	1170					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q96EZ4	reviewed	MYEOV_HUMAN	Myeloma-overexpressed gene protein (Oncogene in multiple myeloma)	MYEOV OCIM	Homo sapiens (Human)	313							
Q96F63	reviewed	CCD97_HUMAN	Coiled-coil domain-containing protein 97	CCDC97	Homo sapiens (Human)	343	FUNCTION: May play a role pre-mRNA splicing through the association with the splicing factor SF3B complex which is involved in branch-site recognition. {ECO:0000269|PubMed:26344197}.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:26344197}.
Q96FB5	reviewed	MT25B_HUMAN	Methyltransferase-like protein 25B (Protein RRNAD1) (Ribosomal RNA adenine dimethylase domain-containing protein 1)	METTL25B C1orf66 RRNAD1 CGI-41	Homo sapiens (Human)	475				membrane [GO:0016020]	rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]	membrane [GO:0016020]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96G27	reviewed	WBP1_HUMAN	WW domain-binding protein 1 (WBP-1)	WBP1	Homo sapiens (Human)	269					WW domain binding [GO:0050699]	WW domain binding [GO:0050699]	
Q96GE5	reviewed	ZN799_HUMAN	Zinc finger protein 799 (Zinc finger protein 842)	ZNF799 ZNF842	Homo sapiens (Human)	643	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96GE6	reviewed	CALL4_HUMAN	Calmodulin-like protein 4 (Serologically defined breast cancer antigen NY-BR-20)	CALML4	Homo sapiens (Human)	196					calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]	calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]	
Q96GK7	reviewed	FAH2A_HUMAN	Fumarylacetoacetate hydrolase domain-containing protein 2A (EC 3.-.-.-)	FAHD2A CGI-105	Homo sapiens (Human)	314	FUNCTION: May have hydrolase activity. {ECO:0000250}.				hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	
Q96GT9	reviewed	XAGE2_HUMAN	X antigen family member 2 (XAGE-2) (Cancer/testis antigen 12.2) (CT12.2) (G antigen family D member 3)	XAGE2 GAGED3 XAGE2B	Homo sapiens (Human)	111							
Q96GU1	reviewed	PAGE5_HUMAN	P antigen family member 5 (PAGE-5) (Cancer/testis antigen 16.1) (CT16.1) (G antigen family E member 1) (Prostate-associated gene 5 protein)	PAGE5 GAGEE1	Homo sapiens (Human)	130							
Q96H12	reviewed	MSD3_HUMAN	Myb/SANT-like DNA-binding domain-containing protein 3	MSANTD3 C9orf30 L8	Homo sapiens (Human)	275							
Q96H40	reviewed	ZN486_HUMAN	Zinc finger protein 486 (KRAB domain only protein 2)	ZNF486 KRBO2	Homo sapiens (Human)	463	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96H79	reviewed	ZCCHL_HUMAN	Zinc finger CCCH-type antiviral protein 1-like	ZC3HAV1L C7orf39	Homo sapiens (Human)	300				cytosol [GO:0005829]		cytosol [GO:0005829]	
Q96HA4	reviewed	CA159_HUMAN	Uncharacterized protein C1orf159	C1orf159 UNQ2998/PRO9739	Homo sapiens (Human)	380				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96HP4	reviewed	OXND1_HUMAN	Oxidoreductase NAD-binding domain-containing protein 1 (EC 1.-.-.-)	OXNAD1	Homo sapiens (Human)	312					oxidoreductase activity [GO:0016491]	oxidoreductase activity [GO:0016491]	
Q96HV5	reviewed	TM41A_HUMAN	Transmembrane protein 41A	TMEM41A UNQ168/PRO194	Homo sapiens (Human)	264				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96I13	reviewed	ABHD8_HUMAN	Protein ABHD8 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 8) (Abhydrolase domain-containing protein 8)	ABHD8	Homo sapiens (Human)	439				extracellular exosome [GO:0070062]	hydrolase activity [GO:0016787]	extracellular exosome [GO:0070062]; hydrolase activity [GO:0016787]	
Q96IC2	reviewed	REXO5_HUMAN	RNA exonuclease 5 (EC 3.1.-.-) (Exonuclease NEF-sp)	REXO5 44M2.3	Homo sapiens (Human)	774				extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleus [GO:0005634]	exonuclease activity [GO:0004527]; RNA binding [GO:0003723]	extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleus [GO:0005634]; exonuclease activity [GO:0004527]; RNA binding [GO:0003723]	
Q96ID5	reviewed	IGS21_HUMAN	Immunoglobulin superfamily member 21 (IgSF21)	IGSF21	Homo sapiens (Human)	467	FUNCTION: Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2. {ECO:0000250|UniProtKB:Q7TNR6}.		heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse maturation [GO:0060074]	adherens junction [GO:0005912]; external side of plasma membrane [GO:0009897]; inhibitory synapse [GO:0060077]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]		adherens junction [GO:0005912]; external side of plasma membrane [GO:0009897]; inhibitory synapse [GO:0060077]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse maturation [GO:0060074]	SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q7TNR6}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q7TNR6}.
Q96J77	reviewed	TPD55_HUMAN	Tumor protein D55 (hD55) (Testis development protein NYD-SP25) (Tumor protein D52-like 3)	TPD52L3	Homo sapiens (Human)	140				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q96JF6	reviewed	ZN594_HUMAN	Zinc finger protein 594 (Zinc finger protein HZF18)	ZNF594 KIAA1871	Homo sapiens (Human)	807	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96JM4	reviewed	LRIQ1_HUMAN	Leucine-rich repeat and IQ domain-containing protein 1	LRRIQ1 KIAA1801	Homo sapiens (Human)	1722			regulation of signal transduction [GO:0009966]			regulation of signal transduction [GO:0009966]	
Q96K17	reviewed	BT3L4_HUMAN	Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4)	BTF3L4	Homo sapiens (Human)	158							
Q96K37	reviewed	S35E1_HUMAN	Solute carrier family 35 member E1	SLC35E1 PSEC0038	Homo sapiens (Human)	410	FUNCTION: Putative transporter. {ECO:0000250}.			Golgi apparatus [GO:0005794]; membrane [GO:0016020]	antiporter activity [GO:0015297]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; antiporter activity [GO:0015297]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96K75	reviewed	ZN514_HUMAN	Zinc finger protein 514	ZNF514	Homo sapiens (Human)	400	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96KC9	reviewed	CABS1_HUMAN	Calcium-binding and spermatid-specific protein 1 (Testis development protein NYD-SP26)	CABS1 C4orf35	Homo sapiens (Human)	395	FUNCTION: Calcium-binding protein (By similarity). Essential for maintaining the structural integrity of the sperm flagella (By similarity). {ECO:0000250|UniProtKB:Q68FX6, ECO:0000250|UniProtKB:Q8C633}.		flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]; mitochondrial inner membrane [GO:0005743]; motile cilium [GO:0031514]; sperm principal piece [GO:0097228]	calcium ion binding [GO:0005509]	acrosomal vesicle [GO:0001669]; mitochondrial inner membrane [GO:0005743]; motile cilium [GO:0031514]; sperm principal piece [GO:0097228]; calcium ion binding [GO:0005509]; flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q68FX6}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q68FX6}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8C633}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8C633}. Note=Mostly cytoplasmic, but associated with the mitochondrial inner membrane during the last steps of spermatid differentiation. Localizes to the principal piece of the sperm flagellum (By similarity). {ECO:0000250|UniProtKB:Q68FX6, ECO:0000250|UniProtKB:Q8C633}.
Q96KD3	reviewed	GAR1B_HUMAN	Golgi-associated RAB2 interactor protein 1B (Testis development protein NYD-SP18)	GARIN1B FAM137A FAM71F1	Homo sapiens (Human)	344	FUNCTION: RAB2B effector protein required for accurate acrosome formation and normal male fertility. In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation. {ECO:0000250|UniProtKB:Q3UZD7}.		acrosome assembly [GO:0001675]; acrosome reaction [GO:0007340]	Golgi apparatus [GO:0005794]		Golgi apparatus [GO:0005794]; acrosome assembly [GO:0001675]; acrosome reaction [GO:0007340]	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q3UZD7}.
Q96KF2	reviewed	PRAC1_HUMAN	Small nuclear protein PRAC1 (Prostate cancer susceptibility candidate protein 1) (Prostate, rectum and colon expressed gene protein)	PRAC1 C17orf92 PRAC	Homo sapiens (Human)	57				cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11340635}.
Q96KJ4	reviewed	MSLNL_HUMAN	Mesothelin-like protein (Pre-pro-megakaryocyte-potentiating-factor-like)	MSLNL C16orf37 MPFL	Homo sapiens (Human)	702	FUNCTION: May play a role in cellular adhesion. {ECO:0000250}.		cell-matrix adhesion [GO:0007160]	cell surface [GO:0009986]; membrane [GO:0016020]		cell surface [GO:0009986]; membrane [GO:0016020]; cell-matrix adhesion [GO:0007160]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q96KN9	reviewed	CXD4_HUMAN	Gap junction delta-4 protein (Connexin-40.1) (Cx40.1)	GJD4 CX40.1	Homo sapiens (Human)	370	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.		cell-cell signaling [GO:0007267]; regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014717]	connexin complex [GO:0005922]	gap junction channel activity [GO:0005243]	connexin complex [GO:0005922]; gap junction channel activity [GO:0005243]; cell-cell signaling [GO:0007267]; regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014717]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
Q96KT7	reviewed	S35G5_HUMAN	Solute carrier family 35 member G5 (Acyl-malonyl-condensing enzyme 1-like protein 2)	SLC35G5 AMAC AMAC1L2	Homo sapiens (Human)	338		MISCELLANEOUS: The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96KV6	reviewed	BT2A3_HUMAN	Putative butyrophilin subfamily 2 member A3	BTN2A3P BTN2A3	Homo sapiens (Human)	586			regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	external side of plasma membrane [GO:0009897]	signaling receptor binding [GO:0005102]	external side of plasma membrane [GO:0009897]; signaling receptor binding [GO:0005102]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Q96KW9	reviewed	SPAC7_HUMAN	Sperm acrosome-associated protein 7	SPACA7 C13orf28	Homo sapiens (Human)	195	FUNCTION: Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion. {ECO:0000250|UniProtKB:Q9D2S4}.		single fertilization [GO:0007338]	acrosomal lumen [GO:0043160]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]		acrosomal lumen [GO:0043160]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9D2S4}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:22495889}. Cytoplasmic vesicle, secretory vesicle, acrosome lumen {ECO:0000250|UniProtKB:Q9D2S4}. Note=Localized in perinuclear pro-acrosomal granules in round spermatides. Localized between the inner and outer acrosomal membranes (matrix or lumen) in spermatozoa. Secreted during acrosome exocytosis. {ECO:0000250|UniProtKB:Q9D2S4}.
Q96L03	reviewed	SPT17_HUMAN	Spermatogenesis-associated protein 17	SPATA17	Homo sapiens (Human)	361			establishment of meiotic spindle localization [GO:0051295]; mitotic cell cycle [GO:0000278]; spindle organization [GO:0007051]	cytoplasm [GO:0005737]; spindle pole [GO:0000922]	calmodulin binding [GO:0005516]	cytoplasm [GO:0005737]; spindle pole [GO:0000922]; calmodulin binding [GO:0005516]; establishment of meiotic spindle localization [GO:0051295]; mitotic cell cycle [GO:0000278]; spindle organization [GO:0007051]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96L11	reviewed	LCFC1_HUMAN	Sperm-egg fusion protein LLCFC1 (LLLL and CFNLAS motif-containing protein 1) (MSSP-binding protein CTM-1) (Sperm-oocyte fusion required protein 1)	LLCFC1 C7orf34 SOF1	Homo sapiens (Human)	122	FUNCTION: Sperm protein required for fusion of sperm with the egg membrane during fertilization. {ECO:0000250|UniProtKB:Q9D9P8}.		fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96LB0	reviewed	MRGX3_HUMAN	Mas-related G-protein coupled receptor member X3 (Sensory neuron-specific G-protein coupled receptor 1/2)	MRGPRX3 MRGX3 SNSR1 SNSR2	Homo sapiens (Human)	322	FUNCTION: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity). {ECO:0000250}.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96LK8	reviewed	SPT32_HUMAN	Spermatogenesis-associated protein 32 (Testis-expressed protein 34)	SPATA32 C17orf46 TEX34	Homo sapiens (Human)	384			spermatogenesis [GO:0007283]	perinuclear region of cytoplasm [GO:0048471]	actin binding [GO:0003779]	perinuclear region of cytoplasm [GO:0048471]; actin binding [GO:0003779]; spermatogenesis [GO:0007283]	
Q96LP2	reviewed	FA81B_HUMAN	Protein FAM81B	FAM81B	Homo sapiens (Human)	452				nucleus [GO:0005634]		nucleus [GO:0005634]	
Q96LQ0	reviewed	PPR36_HUMAN	Protein phosphatase 1 regulatory subunit 36	PPP1R36 C14orf50	Homo sapiens (Human)	422	FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.				phosphatase binding [GO:0019902]; protein phosphatase inhibitor activity [GO:0004864]	phosphatase binding [GO:0019902]; protein phosphatase inhibitor activity [GO:0004864]	
Q96LR4	reviewed	TAFA4_HUMAN	Chemokine-like protein TAFA-4	TAFA4 FAM19A4	Homo sapiens (Human)	140	FUNCTION: Modulates injury-induced and chemical pain hypersensitivity (By similarity). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685). {ECO:0000250|UniProtKB:Q7TPG5, ECO:0000269|PubMed:25109685}.		macrophage chemotaxis [GO:0048246]; phagocytosis [GO:0006909]; regulation of membrane potential [GO:0042391]; regulation of sensory perception of pain [GO:0051930]; regulation of signaling receptor activity [GO:0010469]; superoxide anion generation [GO:0042554]	extracellular space [GO:0005615]	receptor ligand activity [GO:0048018]	extracellular space [GO:0005615]; receptor ligand activity [GO:0048018]; macrophage chemotaxis [GO:0048246]; phagocytosis [GO:0006909]; regulation of membrane potential [GO:0042391]; regulation of sensory perception of pain [GO:0051930]; regulation of signaling receptor activity [GO:0010469]; superoxide anion generation [GO:0042554]	SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15028294, ECO:0000269|PubMed:25109685}.
Q96LT6	reviewed	CA074_HUMAN	UPF0739 protein C1orf74	C1orf74	Homo sapiens (Human)	269							
Q96LU5	reviewed	IMP1L_HUMAN	Mitochondrial inner membrane protease subunit 1 (EC 3.4.21.-) (IMP1-like protein)	IMMP1L	Homo sapiens (Human)	166	FUNCTION: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. {ECO:0000269|PubMed:15814844}.		protein processing involved in protein targeting to mitochondrion [GO:0006627]; signal peptide processing [GO:0006465]	mitochondrial inner membrane [GO:0005743]; mitochondrial inner membrane peptidase complex [GO:0042720]; mitochondrion [GO:0005739]	serine-type endopeptidase activity [GO:0004252]	mitochondrial inner membrane [GO:0005743]; mitochondrial inner membrane peptidase complex [GO:0042720]; mitochondrion [GO:0005739]; serine-type endopeptidase activity [GO:0004252]; protein processing involved in protein targeting to mitochondrion [GO:0006627]; signal peptide processing [GO:0006465]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:15814844}.
Q96LU7	reviewed	MRFL_HUMAN	Myelin regulatory factor-like protein	MYRFL C12orf15 C12orf28	Homo sapiens (Human)	910			positive regulation of DNA-templated transcription [GO:0045893]; protein autoprocessing [GO:0016540]	endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]	endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; positive regulation of DNA-templated transcription [GO:0045893]; protein autoprocessing [GO:0016540]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96LW1	reviewed	Z354B_HUMAN	Zinc finger protein 354B	ZNF354B	Homo sapiens (Human)	612	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96M20	reviewed	CNBD2_HUMAN	Cyclic nucleotide-binding domain-containing protein 2	CNBD2 C20orf152	Homo sapiens (Human)	576	FUNCTION: Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm. {ECO:0000250|UniProtKB:Q9D5U8}.		spermatogenesis [GO:0007283]	cytosol [GO:0005829]	cAMP binding [GO:0030552]	cytosol [GO:0005829]; cAMP binding [GO:0030552]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D5U8}.
Q96M34	reviewed	TEX55_HUMAN	Testis-specific expressed protein 55 (Testis-specific conserved, cAMP-dependent type II PK-anchoring protein)	TEX55 C3orf30 TSCPA	Homo sapiens (Human)	536				nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A6X8Z9}.
Q96M53	reviewed	TBATA_HUMAN	Protein TBATA (Protein SPATIAL) (Stromal protein associated with thymii and lymph node homolog) (Thymus, brain and testes-associated protein)	TBATA C10orf27 SPATIAL	Homo sapiens (Human)	351	FUNCTION: May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	ciliary basal body [GO:0036064]; cytosol [GO:0005829]		ciliary basal body [GO:0036064]; cytosol [GO:0005829]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
Q96M93	reviewed	ADAD1_HUMAN	Adenosine deaminase domain-containing protein 1 (Testis nuclear RNA-binding protein)	ADAD1 TENR	Homo sapiens (Human)	576	FUNCTION: Required for male fertility and normal male germ cell differentiation (By similarity). Plays a role in spermatogenesis (By similarity). Binds to RNA but not to DNA (By similarity). {ECO:0000250|UniProtKB:Q5SUE7}.		adenosine to inosine editing [GO:0006382]; RNA processing [GO:0006396]; spermatid development [GO:0007286]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]	double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; tRNA-specific adenosine deaminase activity [GO:0008251]	cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; tRNA-specific adenosine deaminase activity [GO:0008251]; adenosine to inosine editing [GO:0006382]; RNA processing [GO:0006396]; spermatid development [GO:0007286]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5SUE7}.
Q96M95	reviewed	CCD42_HUMAN	Coiled-coil domain-containing protein 42	CCDC42 CCDC42A	Homo sapiens (Human)	316	FUNCTION: Required for sperm development. {ECO:0000250|UniProtKB:Q5SV66}.		acrosome assembly [GO:0001675]; centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; spermatid development [GO:0007286]			acrosome assembly [GO:0001675]; centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; spermatid development [GO:0007286]	
Q96MC5	reviewed	MERB1_HUMAN	bMERB domain-containing protein 1	BMERB1 C16orf45	Homo sapiens (Human)	204			cell motility involved in cerebral cortex radial glia guided migration [GO:0021814]; microtubule depolymerization [GO:0007019]; negative regulation of cell motility involved in cerebral cortex radial glia guided migration [GO:0021822]; negative regulation of microtubule depolymerization [GO:0007026]	microtubule cytoskeleton [GO:0015630]		microtubule cytoskeleton [GO:0015630]; cell motility involved in cerebral cortex radial glia guided migration [GO:0021814]; microtubule depolymerization [GO:0007019]; negative regulation of cell motility involved in cerebral cortex radial glia guided migration [GO:0021822]; negative regulation of microtubule depolymerization [GO:0007026]	
Q96MC6	reviewed	MF14A_HUMAN	Hippocampus abundant transcript 1 protein (Major facilitator superfamily domain-containing 14A) (Putative tetracycline transporter-like protein)	MFSD14A HIAT1	Homo sapiens (Human)	490			acrosome assembly [GO:0001675]; sperm mitochondrion organization [GO:0030382]; spermatid nucleus differentiation [GO:0007289]	membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]; acrosome assembly [GO:0001675]; sperm mitochondrion organization [GO:0030382]; spermatid nucleus differentiation [GO:0007289]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96ME7	reviewed	ZN512_HUMAN	Zinc finger protein 512	ZNF512 KIAA1805	Homo sapiens (Human)	567	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96MF6	reviewed	CQ10A_HUMAN	Coenzyme Q-binding protein COQ10 homolog A, mitochondrial	COQ10A UNQ6192/PRO20219	Homo sapiens (Human)	247	FUNCTION: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable). {ECO:0000305}.		cellular respiration [GO:0045333]; ubiquinone biosynthetic process [GO:0006744]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	ubiquinone binding [GO:0048039]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ubiquinone binding [GO:0048039]; cellular respiration [GO:0045333]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Q96MK2	reviewed	RIPR3_HUMAN	RIPOR family member 3	RIPOR3 C20orf175 C20orf176 FAM65C	Homo sapiens (Human)	946							
Q96MN5	reviewed	TEAN2_HUMAN	Transcription elongation factor A N-terminal and central domain-containing protein 2	TCEANC2 C1orf83	Homo sapiens (Human)	208			DNA-templated transcription [GO:0006351]	nucleus [GO:0005634]		nucleus [GO:0005634]; DNA-templated transcription [GO:0006351]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649, ECO:0000255|PROSITE-ProRule:PRU00651}.
Q96MR6	reviewed	CFA57_HUMAN	Cilia- and flagella-associated protein 57 (WD repeat-containing protein 65)	CFAP57 WDR65	Homo sapiens (Human)	1250							
Q96MR9	reviewed	ZN560_HUMAN	Zinc finger protein 560	ZNF560	Homo sapiens (Human)	790	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96MS3	reviewed	GL1D1_HUMAN	Glycosyltransferase 1 domain-containing protein 1 (EC 2.4.-.-)	GLT1D1	Homo sapiens (Human)	346				cytosol [GO:0005829]; extracellular region [GO:0005576]	glycosyltransferase activity [GO:0016757]	cytosol [GO:0005829]; extracellular region [GO:0005576]; glycosyltransferase activity [GO:0016757]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96MU6	reviewed	ZN778_HUMAN	Zinc finger protein 778	ZNF778	Homo sapiens (Human)	729	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96MW1	reviewed	CCD43_HUMAN	Coiled-coil domain-containing protein 43	CCDC43	Homo sapiens (Human)	224				cytosol [GO:0005829]		cytosol [GO:0005829]	
Q96MY1	reviewed	NOL4L_HUMAN	Nucleolar protein 4-like	NOL4L C20orf112 C20orf113	Homo sapiens (Human)	436				cytosol [GO:0005829]; nucleoplasm [GO:0005654]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	
Q96N03	reviewed	VTM2L_HUMAN	V-set and transmembrane domain-containing protein 2-like protein	VSTM2L C20orf102	Homo sapiens (Human)	204			negative regulation of neuron apoptotic process [GO:0043524]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]		cytoplasm [GO:0005737]; extracellular region [GO:0005576]; negative regulation of neuron apoptotic process [GO:0043524]	
Q96N11	reviewed	INT15_HUMAN	Integrator complex subunit 15	INTS15 C7orf26	Homo sapiens (Human)	449	FUNCTION: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. {ECO:0000305|PubMed:33973408}.			integrator complex [GO:0032039]		integrator complex [GO:0032039]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:33973408}.
Q96N20	reviewed	ZN75A_HUMAN	Zinc finger protein 75A	ZNF75A	Homo sapiens (Human)	296	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96N22	reviewed	ZN681_HUMAN	Zinc finger protein 681	ZNF681	Homo sapiens (Human)	645	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96N46	reviewed	TTC14_HUMAN	Tetratricopeptide repeat protein 14 (TPR repeat protein 14)	TTC14 KIAA1980 UNQ5813/PRO19630	Homo sapiens (Human)	770		MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site. {ECO:0000305}.			nucleic acid binding [GO:0003676]	nucleic acid binding [GO:0003676]	
Q96NA8	reviewed	TSNA1_HUMAN	t-SNARE domain-containing protein 1	TSNARE1	Homo sapiens (Human)	513			intracellular protein transport [GO:0006886]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	endomembrane system [GO:0012505]; SNARE complex [GO:0031201]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	endomembrane system [GO:0012505]; SNARE complex [GO:0031201]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; intracellular protein transport [GO:0006886]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q96ND8	reviewed	ZN583_HUMAN	Zinc finger protein 583 (Zinc finger protein L3-5)	ZNF583	Homo sapiens (Human)	569	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96NG8	reviewed	ZN582_HUMAN	Zinc finger protein 582	ZNF582	Homo sapiens (Human)	517	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96NI8	reviewed	ZN570_HUMAN	Zinc finger protein 570	ZNF570	Homo sapiens (Human)	536	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96NJ3	reviewed	ZN285_HUMAN	Zinc finger protein 285 (Zinc finger protein 285A)	ZNF285 ZNF285A	Homo sapiens (Human)	590	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96NJ5	reviewed	KLH32_HUMAN	Kelch-like protein 32 (BTB and kelch domain-containing protein 5)	KLHL32 BKLHD5 KIAA1900	Homo sapiens (Human)	620							
Q96NJ6	reviewed	ZFP3_HUMAN	Zinc finger protein 3 homolog (Zfp-3) (Zinc finger protein 752)	ZFP3 ZNF752	Homo sapiens (Human)	502	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96NK8	reviewed	NDF6_HUMAN	Neurogenic differentiation factor 6 (NeuroD6) (Class A basic helix-loop-helix protein 2) (bHLHa2) (Protein atonal homolog 2)	NEUROD6 ATOH2 BHLHA2 My051	Homo sapiens (Human)	337	FUNCTION: Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity). {ECO:0000250}.		axon development [GO:0061564]; dentate gyrus development [GO:0021542]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; axon development [GO:0061564]; dentate gyrus development [GO:0021542]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96NS5	reviewed	ASB16_HUMAN	Ankyrin repeat and SOCS box protein 16 (ASB-16)	ASB16	Homo sapiens (Human)	453	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]		cytosol [GO:0005829]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	
Q96NT1	reviewed	NP1L5_HUMAN	Nucleosome assembly protein 1-like 5 (Down-regulated in liver malignancy)	NAP1L5 DRLM	Homo sapiens (Human)	182			nucleosome assembly [GO:0006334]	nucleus [GO:0005634]		nucleus [GO:0005634]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96NU7	reviewed	HUTI_HUMAN	Probable imidazolonepropionase (EC 3.5.2.7) (Amidohydrolase domain-containing protein 1)	AMDHD1 HMFT1272	Homo sapiens (Human)	426			histidine catabolic process [GO:0006548]; histidine catabolic process to glutamate and formamide [GO:0019556]; histidine catabolic process to glutamate and formate [GO:0019557]	cytosol [GO:0005829]	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; imidazolonepropionase activity [GO:0050480]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; imidazolonepropionase activity [GO:0050480]; metal ion binding [GO:0046872]; histidine catabolic process [GO:0006548]; histidine catabolic process to glutamate and formamide [GO:0019556]; histidine catabolic process to glutamate and formate [GO:0019557]	
Q96P64	reviewed	AGAP4_HUMAN	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 (AGAP-4) (Centaurin-gamma-like family member 1) (Centaurin-gamma-like family member 5)	AGAP4 AGAP8 CTGLF1 CTGLF5 MRIP2	Homo sapiens (Human)	663	FUNCTION: Putative GTPase-activating protein. {ECO:0000305}.	MISCELLANEOUS: Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.			GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]	
Q96P67	reviewed	GPR82_HUMAN	Probable G-protein coupled receptor 82	GPR82	Homo sapiens (Human)	336	FUNCTION: Orphan receptor.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96PG2	reviewed	M4A10_HUMAN	Membrane-spanning 4-domains subfamily A member 10 (CD20 antigen-like 7)	MS4A10 CD20L7 MS4A9	Homo sapiens (Human)	267	FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex.		cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q96PI1	reviewed	SPRR4_HUMAN	Small proline-rich protein 4	SPRR4	Homo sapiens (Human)	79	FUNCTION: Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification.		keratinization [GO:0031424]	cell cortex [GO:0005938]		cell cortex [GO:0005938]; keratinization [GO:0031424]	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cell cortex. Note=Translocates to the cell periphery of keratinocytes and is integrated into both rigid and fragile cornified envelopes.
Q96PT3	reviewed	DUX5_HUMAN	Double homeobox protein 5	DUX5	Homo sapiens (Human)	197		MISCELLANEOUS: DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found on the short arms of all acrocentric chromosomes as well as on several other chromosomes. May be functional despite lack of introns and a poly(A) addition signal.	regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96PT4	reviewed	DUX3_HUMAN	Putative double homeobox protein 3	DUX3	Homo sapiens (Human)	197		MISCELLANEOUS: DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found on the short arms of all acrocentric chromosomes as well as on several other chromosomes. May be functional despite lack of introns and of a poly(A) addition signal.	regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96PX6	reviewed	CC85A_HUMAN	Coiled-coil domain-containing protein 85A	CCDC85A KIAA1912	Homo sapiens (Human)	553	FUNCTION: May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family. {ECO:0000305|PubMed:25009281}.			adherens junction [GO:0005912]		adherens junction [GO:0005912]	SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:25009281}.
Q96QA6	reviewed	YPEL2_HUMAN	Protein yippee-like 2	YPEL2 FKSG4	Homo sapiens (Human)	119				nucleolus [GO:0005730]	metal ion binding [GO:0046872]	nucleolus [GO:0005730]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15556292}.
Q96QD5	reviewed	DEPD7_HUMAN	DEP domain-containing protein 7 (Protein TR2/D15)	DEPDC7	Homo sapiens (Human)	511			intracellular signal transduction [GO:0035556]			intracellular signal transduction [GO:0035556]	
Q96QE4	reviewed	LR37B_HUMAN	Leucine-rich repeat-containing protein 37B (C66 SLIT-like testicular protein)	LRRC37B	Homo sapiens (Human)	947				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q96QH8	reviewed	LYZL5_HUMAN	Sperm acrosome-associated protein 5 (EC 3.2.1.17) (Lysozyme-like protein 5) (Sperm-specific lysozyme-like protein X) (SLLP-X)	SPACA5 LYZL5 SPACA5A UNQ6288/PRO20753; SPACA5B	Homo sapiens (Human)	159			fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; metabolic process [GO:0008152]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; sperm flagellum [GO:0036126]	lysozyme activity [GO:0003796]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; sperm flagellum [GO:0036126]; lysozyme activity [GO:0003796]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; metabolic process [GO:0008152]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96QK8	reviewed	SIM14_HUMAN	Small integral membrane protein 14	SMIM14 C4orf34	Homo sapiens (Human)	99			blastocyst hatching [GO:0001835]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; blastocyst hatching [GO:0001835]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24499674}; Single-pass membrane protein {ECO:0000269|PubMed:24499674}.
Q96QZ0	reviewed	PANX3_HUMAN	Pannexin-3	PANX3	Homo sapiens (Human)	392	FUNCTION: Structural component of the gap junctions and the hemichannels.		cell-cell signaling [GO:0007267]; monoatomic cation transport [GO:0006812]; positive regulation of interleukin-1 production [GO:0032732]	gap junction [GO:0005921]; plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]; wide pore channel activity [GO:0022829]	gap junction [GO:0005921]; plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]; wide pore channel activity [GO:0022829]; cell-cell signaling [GO:0007267]; monoatomic cation transport [GO:0006812]; positive regulation of interleukin-1 production [GO:0032732]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap junction.
Q96R05	reviewed	RET7_HUMAN	Retinoid-binding protein 7 (Cellular retinoic acid-binding protein 4) (CRABP4) (CRBP4) (Cellular retinoic acid-binding protein IV) (CRABP-IV)	RBP7	Homo sapiens (Human)	134	FUNCTION: Intracellular transport of retinol. {ECO:0000269|PubMed:12177003}.		fatty acid transport [GO:0015908]	cytosol [GO:0005829]; nucleus [GO:0005634]	fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinol binding [GO:0019841]	cytosol [GO:0005829]; nucleus [GO:0005634]; fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinol binding [GO:0019841]; fatty acid transport [GO:0015908]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96R08	reviewed	OR5BC_HUMAN	Olfactory receptor 5B12 (Olfactory receptor 5B16) (Olfactory receptor OR11-241)	OR5B12 OR5B12P OR5B16	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96R09	reviewed	OR5B2_HUMAN	Olfactory receptor 5B2 (OST073) (Olfactory receptor OR11-240)	OR5B2	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96R27	reviewed	OR2M4_HUMAN	Olfactory receptor 2M4 (HTPCRX18) (OST710) (Olfactory receptor OR1-55) (Olfactory receptor TPCR100)	OR2M4	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96R28	reviewed	OR2M2_HUMAN	Olfactory receptor 2M2 (OST423)	OR2M2	Homo sapiens (Human)	347	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96R30	reviewed	OR2V2_HUMAN	Olfactory receptor 2V2 (Olfactory receptor 2V3) (Olfactory receptor OR5-3)	OR2V2 OR2V3	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96R45	reviewed	OR2A7_HUMAN	Olfactory receptor 2A7 (Olfactory receptor OR7-18)	OR2A7	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96R47	reviewed	O2A14_HUMAN	Olfactory receptor 2A14 (OST182) (Olfactory receptor 2A6) (Olfactory receptor OR7-12)	OR2A14 OR2A14P OR2A6	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96R54	reviewed	O14A2_HUMAN	Olfactory receptor 14A2 (Olfactory receptor 5AX1) (Olfactory receptor OR1-31)	OR14A2 OR5AX1 OR5AX1P	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96R67	reviewed	OR4CC_HUMAN	Olfactory receptor 4C12 (Olfactory receptor OR11-259)	OR4C12	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96R69	reviewed	OR4F4_HUMAN	Olfactory receptor 4F4 (HS14a-1-A) (Olfactory receptor OR19-3)	OR4F4	Homo sapiens (Human)	305	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96R72	reviewed	OR4K3_HUMAN	Olfactory receptor 4K3 (Olfactory receptor OR14-14)	OR4K3 OR4K3P	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96R84	reviewed	OR1F2_HUMAN	Putative olfactory receptor 1F2 (OLFmf2)	OR1F2P OR1F2	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RB7	reviewed	OR5MB_HUMAN	Olfactory receptor 5M11	OR5M11	Homo sapiens (Human)	305	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RC9	reviewed	OR8B4_HUMAN	Olfactory receptor 8B4 (Olfactory receptor OR11-315)	OR8B4 OR8B4P	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RD0	reviewed	OR8B2_HUMAN	Olfactory receptor 8B2 (Olfactory receptor OR11-309)	OR8B2	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RD1	reviewed	OR6C1_HUMAN	Olfactory receptor 6C1 (OST267)	OR6C1	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RD2	reviewed	O52B2_HUMAN	Olfactory receptor 52B2 (Olfactory receptor OR11-70)	OR52B2	Homo sapiens (Human)	323	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RD3	reviewed	O52E6_HUMAN	Olfactory receptor 52E6 (Olfactory receptor OR11-58)	OR52E6	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q96RM1	reviewed	SPR2F_HUMAN	Small proline-rich protein 2F (SPR-2F)	SPRR2F	Homo sapiens (Human)	72	FUNCTION: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). {ECO:0000250}.		epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]	cornified envelope [GO:0001533]; cytosol [GO:0005829]		cornified envelope [GO:0001533]; cytosol [GO:0005829]; epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q96RP8	reviewed	KCNA7_HUMAN	Potassium voltage-gated channel subfamily A member 7 (Voltage-gated potassium channel subunit Kv1.7)	KCNA7	Homo sapiens (Human)	456	FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity). {ECO:0000250}.		potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	delayed rectifier potassium channel activity [GO:0005251]	plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; delayed rectifier potassium channel activity [GO:0005251]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of monoatomic ion transmembrane transport [GO:0034765]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q96RT6	reviewed	CTGE2_HUMAN	cTAGE family member 2 (Protein cTAGE-2) (Cancer/testis antigen 21.2) (CT21.2)	CTAGE1 CTAGE2	Homo sapiens (Human)	745			endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96RY5	reviewed	CRML_HUMAN	Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein)	CRAMP1 C16orf34 CRAMP1L HN1L KIAA1426	Homo sapiens (Human)	1269			pattern specification process [GO:0007389]	nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; pattern specification process [GO:0007389]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
Q96S19	reviewed	MTL26_HUMAN	Methyltransferase-like 26	METTL26 JFP2 C16orf13	Homo sapiens (Human)	204					S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	
Q96S86	reviewed	HPLN3_HUMAN	Hyaluronan and proteoglycan link protein 3	HAPLN3 EXLD1 UNQ238/PRO271	Homo sapiens (Human)	360	FUNCTION: May function in hyaluronic acid binding. {ECO:0000303|PubMed:12663660}.		cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]	extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202]	hyaluronic acid binding [GO:0005540]	extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202]; hyaluronic acid binding [GO:0005540]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Q96S95	reviewed	CK2N2_HUMAN	Calcium/calmodulin-dependent protein kinase II inhibitor 2 (CaM-KII inhibitory protein) (CaM-KIIN)	CAMK2N2	Homo sapiens (Human)	79	FUNCTION: Potent and specific cellular inhibitor of CaM-kinase II (CAMK2) (PubMed:11444830). Traps Ca(2+)/calmodulin on CAMK2 (By similarity). {ECO:0000250|UniProtKB:Q9Z2N6, ECO:0000269|PubMed:11444830}.			cytosol [GO:0005829]; nucleus [GO:0005634]; synapse [GO:0045202]	calcium-dependent protein kinase inhibitor activity [GO:0008427]; protein kinase binding [GO:0019901]	cytosol [GO:0005829]; nucleus [GO:0005634]; synapse [GO:0045202]; calcium-dependent protein kinase inhibitor activity [GO:0008427]; protein kinase binding [GO:0019901]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Z2N6}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z2N6}. Synapse {ECO:0000250|UniProtKB:Q78WH7}. Note=Excluded from nucleus when coexpressed with activated CAMK2. {ECO:0000250|UniProtKB:Q9Z2N6}.
Q96SA4	reviewed	SERC2_HUMAN	Serine incorporator 2 (Tumor differentially expressed protein 2-like)	SERINC2 TDE2L FKSG84 UNQ263/PRO300	Homo sapiens (Human)	455				extracellular exosome [GO:0070062]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96SF2	reviewed	TCPQM_HUMAN	T-complex protein 1 subunit theta-like 2	CCT8L2 CESK1	Homo sapiens (Human)	557	FUNCTION: Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis. {ECO:0000250|UniProtKB:P40227}.	MISCELLANEOUS: Presence of two highly similar CCT8L genes (CCT8L1P and CCT8L2) in the genomes of human and chimp and of a single copy in other mammal genomes, including rhesus monkey, suggests that the duplication of this gene occurred in the ape lineage (Hominoidea) after its divergence from the old-world monkeys (Cercopithecidae). {ECO:0000303|PubMed:20193073}.; MISCELLANEOUS: Expression of CCT8L2 is confirmed by many ESTs mostly identified from the testis. {ECO:0000305|PubMed:20193073}.	protein folding [GO:0006457]	chaperonin-containing T-complex [GO:0005832]	ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; calcium-activated potassium channel activity [GO:0015269]; monoatomic anion channel activity [GO:0005253]; unfolded protein binding [GO:0051082]	chaperonin-containing T-complex [GO:0005832]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; calcium-activated potassium channel activity [GO:0015269]; monoatomic anion channel activity [GO:0005253]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40227}.
Q96SK2	reviewed	TM209_HUMAN	Transmembrane protein 209	TMEM209	Homo sapiens (Human)	561				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96T17	reviewed	MA7D2_HUMAN	MAP7 domain-containing protein 2	MAP7D2	Homo sapiens (Human)	732			microtubule cytoskeleton organization [GO:0000226]	microtubule cytoskeleton [GO:0015630]		microtubule cytoskeleton [GO:0015630]; microtubule cytoskeleton organization [GO:0000226]	
Q96T75	reviewed	DSCR8_HUMAN	Down syndrome critical region protein 8 (Cancer/testis antigen 25) (CT25) (DCR1-24.0) (Malignant melanoma-associated protein 1) (MMA-1) (Protein MTAG2)	DSCR8 C21orf65 MTAG2	Homo sapiens (Human)	97		MISCELLANEOUS: Potential cancer-testis antigen, with expression restricted to the testis and certain malignant cells. {ECO:0000305|PubMed:15472897}.; MISCELLANEOUS: [Isoform 1]: Predominantly expressed in the testis. {ECO:0000269|PubMed:11920614, ECO:0000269|PubMed:15472897}.; MISCELLANEOUS: [Isoform 3]: Predominantly expressed in the testis, at lower level in the placenta, during malignant progression of melanocytic tumors and in several tumors of varying origins. {ECO:0000269|PubMed:11920614, ECO:0000269|PubMed:15472897}.; MISCELLANEOUS: [Isoform 4]: Predominantly expressed in the testis, at lower level in the placenta, during malignant progression of melanocytic tumors and in several tumors of varying origins. {ECO:0000269|PubMed:11920614, ECO:0000269|PubMed:15472897}.; MISCELLANEOUS: [Isoform 5]: Predominantly expressed in the testis. {ECO:0000269|PubMed:11920614, ECO:0000269|PubMed:15472897}.; MISCELLANEOUS: [Isoform 6]: Predominantly expressed in the testis. {ECO:0000269|PubMed:11920614, ECO:0000269|PubMed:15472897}.					
Q96TA0	reviewed	PCDBI_HUMAN	Putative protocadherin beta-18 (PCDH-beta-18) (PCDH-psi2)	PCDHB18P PCDHB18	Homo sapiens (Human)	734	FUNCTION: Potential calcium-dependent cell-adhesion protein. {ECO:0000250}.		cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q99457	reviewed	NP1L3_HUMAN	Nucleosome assembly protein 1-like 3	NAP1L3 BNAP	Homo sapiens (Human)	506			nucleosome assembly [GO:0006334]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; nucleosome assembly [GO:0006334]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q99463	reviewed	NPY6R_HUMAN	Putative neuropeptide Y receptor type 6 (NPY6-R) (NPY Y1-like receptor) (Putative pancreatic polypeptide receptor 2) (PP2)	NPY6R NPY1RL Y2B	Homo sapiens (Human)	290	FUNCTION: When expressed, is unable to bind pancreatic polypeptide (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function. {ECO:0000269|PubMed:8910290, ECO:0000269|PubMed:8910373}.			neuron projection [GO:0043005]; plasma membrane [GO:0005886]	neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q99470	reviewed	SDF2_HUMAN	Stromal cell-derived factor 2 (SDF-2)	SDF2	Homo sapiens (Human)	211			chaperone cofactor-dependent protein refolding [GO:0051085]	endoplasmic reticulum [GO:0005783]; protein folding chaperone complex [GO:0101031]	misfolded protein binding [GO:0051787]	endoplasmic reticulum [GO:0005783]; protein folding chaperone complex [GO:0101031]; misfolded protein binding [GO:0051787]; chaperone cofactor-dependent protein refolding [GO:0051085]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q99603	reviewed	TRGV9_HUMAN	T cell receptor gamma variable 9	TRGV9 TCRGV9	Homo sapiens (Human)	122	FUNCTION: V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]; innate immune response [GO:0045087]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
Q99676	reviewed	ZN184_HUMAN	Zinc finger protein 184	ZNF184	Homo sapiens (Human)	751	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q99679	reviewed	GPR21_HUMAN	Probable G-protein coupled receptor 21	GPR21	Homo sapiens (Human)	349	FUNCTION: Orphan receptor.		glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of multicellular organism growth [GO:0040018]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of multicellular organism growth [GO:0040018]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q99680	reviewed	GPR22_HUMAN	G-protein coupled receptor 22	GPR22	Homo sapiens (Human)	433	FUNCTION: Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (PubMed:18539757). May be involved in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:A0A2R9YJI3, ECO:0000269|PubMed:18539757}.		cell projection organization [GO:0030030]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]; cell projection organization [GO:0030030]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:D4A3U0}; Multi-pass membrane protein {ECO:0000255}.
Q9BPW5	reviewed	RSLBB_HUMAN	Ras-like protein family member 11B (EC 3.6.5.2)	RASL11B	Homo sapiens (Human)	248			negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]		G protein activity [GO:0003925]; GTP binding [GO:0005525]; transforming growth factor beta receptor binding [GO:0005160]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; transforming growth factor beta receptor binding [GO:0005160]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	
Q9BQ13	reviewed	KCD14_HUMAN	BTB/POZ domain-containing protein KCTD14	KCTD14	Homo sapiens (Human)	255			protein homooligomerization [GO:0051260]			protein homooligomerization [GO:0051260]	
Q9BQ48	reviewed	RM34_HUMAN	Large ribosomal subunit protein bL34m (39S ribosomal protein L34, mitochondrial) (L34mt) (MRP-L34)	MRPL34	Homo sapiens (Human)	92			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Q9BQ75	reviewed	CMS1_HUMAN	Protein CMSS1 (Cms1 ribosomal small subunit homolog)	CMSS1 C3orf26	Homo sapiens (Human)	279					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q9BQD1	reviewed	MCHL2_HUMAN	Putative pro-MCH-like protein 2 (Pro-melanin-concentrating hormone-like protein 2)	PMCHL2	Homo sapiens (Human)	86			chemical synaptic transmission [GO:0007268]	synapse [GO:0045202]	melanin-concentrating hormone activity [GO:0030354]; type 1 melanin-concentrating hormone receptor binding [GO:0031777]	synapse [GO:0045202]; melanin-concentrating hormone activity [GO:0030354]; type 1 melanin-concentrating hormone receptor binding [GO:0031777]; chemical synaptic transmission [GO:0007268]	
Q9BQE6	reviewed	LBHD1_HUMAN	LBH domain-containing protein 1	LBHD1 C11orf48	Homo sapiens (Human)	289			positive regulation of DNA-templated transcription [GO:0045893]	nucleus [GO:0005634]		nucleus [GO:0005634]; positive regulation of DNA-templated transcription [GO:0045893]	
Q9BQN1	reviewed	FA83C_HUMAN	Protein FAM83C	FAM83C C20orf128	Homo sapiens (Human)	747	FUNCTION: May play a role in MAPK signaling. {ECO:0000303|PubMed:24736947}.		epidermal growth factor receptor signaling pathway [GO:0007173]		protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]; epidermal growth factor receptor signaling pathway [GO:0007173]	
Q9BQP9	reviewed	BPIA3_HUMAN	BPI fold-containing family A member 3 (Short palate, lung and nasal epithelium carcinoma-associated protein 3)	BPIFA3 C20orf71 SPLUNC3	Homo sapiens (Human)	254				extracellular region [GO:0005576]	lipid binding [GO:0008289]	extracellular region [GO:0005576]; lipid binding [GO:0008289]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BQY6	reviewed	WFDC6_HUMAN	WAP four-disulfide core domain protein 6 (Putative protease inhibitor WAP6)	WFDC6 C20orf171 WAP6	Homo sapiens (Human)	131				extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BR09	reviewed	NEUL2_HUMAN	Neuralized-like protein 2	NEURL2 C20orf163	Homo sapiens (Human)	285	FUNCTION: Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity). {ECO:0000250}.		intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9BR10	reviewed	SPT25_HUMAN	Spermatogenesis-associated protein 25 (Testis-specific gene 23 protein)	SPATA25 C20orf165 TSG23	Homo sapiens (Human)	227	FUNCTION: May play a role in spermatogenesis. {ECO:0000269|PubMed:19240080}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9BR26	reviewed	OCSTP_HUMAN	Osteoclast stimulatory transmembrane protein (OC-STAMP)	OCSTAMP C20orf123	Homo sapiens (Human)	566	FUNCTION: Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity). {ECO:0000250}.		cellular response to estrogen stimulus [GO:0071391]; cellular response to tumor necrosis factor [GO:0071356]; multinuclear osteoclast differentiation [GO:0072674]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of osteoclast proliferation [GO:0090290]	membrane [GO:0016020]		membrane [GO:0016020]; cellular response to estrogen stimulus [GO:0071391]; cellular response to tumor necrosis factor [GO:0071356]; multinuclear osteoclast differentiation [GO:0072674]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of osteoclast proliferation [GO:0090290]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9BR77	reviewed	CCD77_HUMAN	Coiled-coil domain-containing protein 77	CCDC77	Homo sapiens (Human)	488				centrosome [GO:0005813]; membrane [GO:0016020]		centrosome [GO:0005813]; membrane [GO:0016020]	
Q9BRH9	reviewed	ZN251_HUMAN	Zinc finger protein 251	ZNF251	Homo sapiens (Human)	671	FUNCTION: May be involved in transcriptional regulation.		hematopoietic stem cell homeostasis [GO:0061484]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; hematopoietic stem cell homeostasis [GO:0061484]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BRN9	reviewed	TM2D3_HUMAN	TM2 domain-containing protein 3 (Beta-amyloid-binding protein-like protein 2) (BBP-like protein 2)	TM2D3 BLP2	Homo sapiens (Human)	247			lateral inhibition [GO:0046331]; positive regulation of Notch signaling pathway [GO:0045747]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; lateral inhibition [GO:0046331]; positive regulation of Notch signaling pathway [GO:0045747]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9BRP7	reviewed	FDXA1_HUMAN	Ferredoxin-fold anticodon-binding domain-containing protein 1 (FDX-ACDB domain-containing protein 1)	FDXACB1	Homo sapiens (Human)	624			rRNA base methylation [GO:0070475]	cytoplasm [GO:0005737]	rRNA (uridine-N3-)-methyltransferase activity [GO:0070042]	cytoplasm [GO:0005737]; rRNA (uridine-N3-)-methyltransferase activity [GO:0070042]; rRNA base methylation [GO:0070475]	
Q9BSC4	reviewed	NOL10_HUMAN	Nucleolar protein 10	NOL10	Homo sapiens (Human)	688			maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	nucleolus [GO:0005730]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Q9BSJ1	reviewed	TRI51_HUMAN	Tripartite motif-containing protein 51 (SPRY domain-containing protein 5)	TRIM51 SPRYD5	Homo sapiens (Human)	452			innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
Q9BSK0	reviewed	MALD1_HUMAN	MARVEL domain-containing protein 1	MARVELD1 MRVLDC1	Homo sapiens (Human)	173	FUNCTION: Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration. {ECO:0000250}.	MISCELLANEOUS: Down-regulated in primary multiple tumors derived from ovary, vulva, uterus, cervix, breast, testis, kidney bladder and liver. The reduced expression is owing to DNA methylation and could be reversed by pharmacologic demethylation (PubMed:19364627). {ECO:0000305|PubMed:19364627}.	cell cycle [GO:0007049]; myelination [GO:0042552]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	structural constituent of myelin sheath [GO:0019911]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; structural constituent of myelin sheath [GO:0019911]; cell cycle [GO:0007049]; myelination [GO:0042552]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000269|PubMed:19364627}. Note=Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the plasma membrane during anaphase or upon microtubule depolymerization (By similarity). {ECO:0000250}.
Q9BSY4	reviewed	CHCH5_HUMAN	Coiled-coil-helix-coiled-coil-helix domain-containing protein 5	CHCHD5 C2orf9	Homo sapiens (Human)	110			cellular respiration [GO:0045333]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]		mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; cellular respiration [GO:0045333]	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000305}.
Q9BT73	reviewed	PSMG3_HUMAN	Proteasome assembly chaperone 3 (PAC-3) (hPAC3)	PSMG3 C7orf48 PAC3	Homo sapiens (Human)	122	FUNCTION: Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes. {ECO:0000269|PubMed:17189198}.		chaperone-mediated protein complex assembly [GO:0051131]; proteasome assembly [GO:0043248]	protein-containing complex [GO:0032991]	molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]	protein-containing complex [GO:0032991]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; chaperone-mediated protein complex assembly [GO:0051131]; proteasome assembly [GO:0043248]	
Q9BTE0	reviewed	NAT9_HUMAN	Alpha/beta-tubulin-N-acetyltransferase 9 (EC 2.3.1.308) (Embryo brain-specific protein)	NAT9 EBS	Homo sapiens (Human)	207	FUNCTION: N-acetyltransferase that mediates the acetylation of the N-terminal residues of alpha- and beta-tubulin. {ECO:0000269|PubMed:33479178}.			protein-containing complex [GO:0032991]	N-acetyltransferase activity [GO:0008080]	protein-containing complex [GO:0032991]; N-acetyltransferase activity [GO:0008080]	
Q9BTF0	reviewed	THUM2_HUMAN	THUMP domain-containing protein 2	THUMPD2 C2orf8	Homo sapiens (Human)	503			tRNA methylation [GO:0030488]		RNA binding [GO:0003723]; tRNA (guanine) methyltransferase activity [GO:0016423]	RNA binding [GO:0003723]; tRNA (guanine) methyltransferase activity [GO:0016423]; tRNA methylation [GO:0030488]	
Q9BTV7	reviewed	CABL2_HUMAN	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2)	CABLES2 C20orf150	Homo sapiens (Human)	478	FUNCTION: Unknown. Probably involved in G1-S cell cycle transition.		cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of cell cycle [GO:0051726]			cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of cell cycle [GO:0051726]	
Q9BTY7	reviewed	HGH1_HUMAN	Protein HGH1 homolog	HGH1 C8orf30A C8orf30B FAM203A FAM203B	Homo sapiens (Human)	390							
Q9BUA6	reviewed	MYL10_HUMAN	Myosin regulatory light chain 10 (Myosin light chain 2, lymphocyte-specific) (Precursor lymphocyte-specific regulatory light chain)	MYL10 MYLC2PL PLRLC	Homo sapiens (Human)	226		MISCELLANEOUS: This chain binds calcium. {ECO:0000250}.		cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; calcium ion binding [GO:0005509]	
Q9BUJ0	reviewed	ABHEA_HUMAN	Protein ABHD14A (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 14A) (Abhydrolase domain-containing protein 14A)	ABHD14A UNQ1913/PRO4373	Homo sapiens (Human)	271	FUNCTION: Possible role in granule neuron development. {ECO:0000250}.			cytoplasm [GO:0005737]; membrane [GO:0016020]	hydrolase activity [GO:0016787]	cytoplasm [GO:0005737]; membrane [GO:0016020]; hydrolase activity [GO:0016787]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9BUY7	reviewed	EFC11_HUMAN	EF-hand calcium-binding domain-containing protein 11	EFCAB11 C14orf143	Homo sapiens (Human)	163		MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.			calcium ion binding [GO:0005509]	calcium ion binding [GO:0005509]	
Q9BV87	reviewed	CNPD1_HUMAN	Protein CNPPD1 (Cyclin Pas1/PHO80 domain-containing protein 1)	CNPPD1 C2orf24 CDABP0125 CGI-57	Homo sapiens (Human)	410				cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; membrane [GO:0016020]; nucleus [GO:0005634]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; membrane [GO:0016020]; nucleus [GO:0005634]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9BV97	reviewed	ZN747_HUMAN	Zinc finger protein 747	ZNF747	Homo sapiens (Human)	330			regulation of DNA-templated transcription [GO:0006355]		metal ion binding [GO:0046872]	metal ion binding [GO:0046872]; regulation of DNA-templated transcription [GO:0006355]	
Q9BVM2	reviewed	DPCD_HUMAN	Protein DPCD	DPCD	Homo sapiens (Human)	203	FUNCTION: May play a role in the formation or function of ciliated cells. {ECO:0000269|PubMed:14630615}.		determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; lateral ventricle development [GO:0021670]; spermatogenesis [GO:0007283]; third ventricle development [GO:0021678]	extracellular region [GO:0005576]; nucleus [GO:0005634]		extracellular region [GO:0005576]; nucleus [GO:0005634]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; lateral ventricle development [GO:0021670]; spermatogenesis [GO:0007283]; third ventricle development [GO:0021678]	
Q9BVV8	reviewed	F174C_HUMAN	Protein FAM174C	FAM174C C19orf24	Homo sapiens (Human)	132				cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]		cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9BWD3	reviewed	RTL8A_HUMAN	Retrotransposon Gag-like protein 8A (Mammalian retrotransposon derived protein 8A)	RTL8A CXX1B FAM127B MAR8A	Homo sapiens (Human)	113		MISCELLANEOUS: RTL8A is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. {ECO:0000269|PubMed:16093683}.					
Q9BWG4	reviewed	SSBP4_HUMAN	Single-stranded DNA-binding protein 4	SSBP4	Homo sapiens (Human)	385			positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleus [GO:0005634]	single-stranded DNA binding [GO:0003697]	nucleus [GO:0005634]; single-stranded DNA binding [GO:0003697]; positive regulation of transcription by RNA polymerase II [GO:0045944]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9BWM5	reviewed	ZN416_HUMAN	Zinc finger protein 416	ZNF416	Homo sapiens (Human)	594	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BWT6	reviewed	MND1_HUMAN	Meiotic nuclear division protein 1 homolog	MND1 GAJ	Homo sapiens (Human)	205	FUNCTION: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. {ECO:0000250|UniProtKB:Q8K396, ECO:0000269|PubMed:16407260}.		homologous chromosome pairing at meiosis [GO:0007129]; reciprocal meiotic recombination [GO:0007131]	nucleus [GO:0005634]	double-stranded DNA binding [GO:0003690]	nucleus [GO:0005634]; double-stranded DNA binding [GO:0003690]; homologous chromosome pairing at meiosis [GO:0007129]; reciprocal meiotic recombination [GO:0007131]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BWV2	reviewed	SPAT9_HUMAN	Spermatogenesis-associated protein 9 (Testis development protein NYD-SP16)	SPATA9	Homo sapiens (Human)	254	FUNCTION: May play a role in testicular development/spermatogenesis and may be an important factor in male infertility. {ECO:0000269|PubMed:12493713}.	MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9BWW9	reviewed	APOL5_HUMAN	Apolipoprotein L5 (Apolipoprotein L-V) (ApoL-V)	APOL5	Homo sapiens (Human)	433	FUNCTION: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.		lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	high-density lipoprotein particle binding [GO:0008035]; lipid binding [GO:0008289]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; high-density lipoprotein particle binding [GO:0008035]; lipid binding [GO:0008289]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q9BX69	reviewed	CARD6_HUMAN	Caspase recruitment domain-containing protein 6	CARD6	Homo sapiens (Human)	1037	FUNCTION: May be involved in apoptosis.		apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981]			apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981]	
Q9BX73	reviewed	TM2D2_HUMAN	TM2 domain-containing protein 2 (Beta-amyloid-binding protein-like protein 1) (BBP-like protein 1)	TM2D2 BLP1	Homo sapiens (Human)	214				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9BXE9	reviewed	VN1R3_HUMAN	Vomeronasal type-1 receptor 3 (V1r-like receptor 3)	VN1R3 V1RL3 FKSG46	Homo sapiens (Human)	311	FUNCTION: Putative pheromone receptor.	MISCELLANEOUS: The gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.	response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606]	plasma membrane [GO:0005886]	pheromone receptor activity [GO:0016503]	plasma membrane [GO:0005886]; pheromone receptor activity [GO:0016503]; response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9BXM9	reviewed	FSD1L_HUMAN	FSD1-like protein (Coiled-coil domain-containing protein 10) (FSD1 N-terminal-like protein)	FSD1L CCDC10 CSDUFD1 FSD1CL FSD1NL	Homo sapiens (Human)	530		MISCELLANEOUS: [Isoform 3]: Due to intron retention. {ECO:0000305}.					
Q9BXN6	reviewed	SPNXD_HUMAN	Sperm protein associated with the nucleus on the X chromosome D (Cancer/testis antigen 11.4) (CT11.4) (Nuclear-associated protein SPAN-Xd) (SPANX-D) (SPANX family member D)	SPANXD SPANXE	Homo sapiens (Human)	97				cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with nuclear craters. {ECO:0000250}.
Q9BXU3	reviewed	TX13A_HUMAN	Testis-expressed protein 13A	TEX13A	Homo sapiens (Human)	409					metal ion binding [GO:0046872]; mRNA binding [GO:0003729]	metal ion binding [GO:0046872]; mRNA binding [GO:0003729]	
Q9BXU8	reviewed	FHL17_HUMAN	Ferritin heavy polypeptide-like 17 (Cancer/testis antigen 38) (CT38)	FTHL17	Homo sapiens (Human)	183			intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826]	cytoplasm [GO:0005737]	ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]	cytoplasm [GO:0005737]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826]	
Q9BXW7	reviewed	HDHD5_HUMAN	Haloacid dehalogenase-like hydrolase domain-containing 5 (Cat eye syndrome critical region protein 5)	HDHD5 CECR5	Homo sapiens (Human)	423		MISCELLANEOUS: Candidate gene for the Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. Duplication usually takes in the form of a surpernumerary bisatellited isodicentric chromosome, resulting in four copies of the region (represents an inv dup(22)(q11)). CES is characterized clinically by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development.	glycerophospholipid biosynthetic process [GO:0046474]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; glycerophospholipid biosynthetic process [GO:0046474]	
Q9BXX2	reviewed	AN30B_HUMAN	Ankyrin repeat domain-containing protein 30B (Serologically defined breast cancer antigen NY-BR-1.1)	ANKRD30B	Homo sapiens (Human)	1392		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q9BXX3	reviewed	AN30A_HUMAN	Ankyrin repeat domain-containing protein 30A (Serologically defined breast cancer antigen NY-BR-1)	ANKRD30A	Homo sapiens (Human)	1397							
Q9BXY0	reviewed	MAK16_HUMAN	Protein MAK16 homolog (NNP78) (Protein RBM13)	MAK16 RBM13	Homo sapiens (Human)	300			maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]	intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]	RNA binding [GO:0003723]	intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]; RNA binding [GO:0003723]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849}.
Q9BXY5	reviewed	CAYP2_HUMAN	Calcyphosin-2 (Calcyphosine-2)	CAPS2 UG0636c06	Homo sapiens (Human)	557					calcium ion binding [GO:0005509]	calcium ion binding [GO:0005509]	
Q9BY19	reviewed	M4A8_HUMAN	Membrane-spanning 4-domains subfamily A member 8 (Four-span transmembrane protein 4) (Membrane-spanning 4-domains subfamily A member 8B)	MS4A8 4SPAN4 MS4A8B	Homo sapiens (Human)	250	FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex.		cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9BY31	reviewed	ZN717_HUMAN	Zinc finger protein 717 (Krueppel-like factor X17)	ZNF717	Homo sapiens (Human)	914	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BY71	reviewed	LRRC3_HUMAN	Leucine-rich repeat-containing protein 3	LRRC3 C21orf102 LRRC3A UNQ9233/PRO31982	Homo sapiens (Human)	257				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9BYB4	reviewed	GNB1L_HUMAN	Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (DGCRK3) (WD repeat-containing protein 14) (WD40 repeat-containing protein deleted in VCFS) (WDVCF)	GNB1L GY2 KIAA1645 WDR14 FKSG1	Homo sapiens (Human)	327							
Q9BYD6	reviewed	RM01_HUMAN	Large ribosomal subunit protein uL1m (39S ribosomal protein L1, mitochondrial) (L1mt) (MRP-L1)	MRPL1 BM-022	Homo sapiens (Human)	325			mitochondrial translation [GO:0032543]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:A6QPQ5, ECO:0000305|PubMed:11279069}.
Q9BYE4	reviewed	SPR2G_HUMAN	Small proline-rich protein 2G (SPR-2G)	SPRR2G	Homo sapiens (Human)	73	FUNCTION: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). {ECO:0000250}.		epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]	cornified envelope [GO:0001533]; cytosol [GO:0005829]		cornified envelope [GO:0001533]; cytosol [GO:0005829]; epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9BYG7	reviewed	MSTRO_HUMAN	Protein maestro (Male-specific transcription in the developing reproductive organs) (Protein B29)	MRO B29 C18orf3	Homo sapiens (Human)	248				nucleolus [GO:0005730]		nucleolus [GO:0005730]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
Q9BYJ0	reviewed	FGFP2_HUMAN	Fibroblast growth factor-binding protein 2 (FGF-BP2) (FGF-binding protein 2) (FGFBP-2) (37 kDa killer-specific secretory protein) (Ksp37) (HBp17-related protein) (HBp17-RP)	FGFBP2 KSP37 UNQ425/PRO1065	Homo sapiens (Human)	223			cell-cell signaling [GO:0007267]	extracellular space [GO:0005615]	growth factor binding [GO:0019838]	extracellular space [GO:0005615]; growth factor binding [GO:0019838]; cell-cell signaling [GO:0007267]	SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:11342666}.
Q9BYT5	reviewed	KRA22_HUMAN	Keratin-associated protein 2-2 (High sulfur keratin-associated protein 2.2) (Keratin-associated protein 2.2)	KRTAP2-2 KAP2.2 KRTAP2.2	Homo sapiens (Human)	123	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q9BYU5	reviewed	KRA21_HUMAN	Keratin-associated protein 2-1 (High sulfur keratin-associated protein 2.1) (Keratin-associated protein 2.1)	KRTAP2-1 KAP2.1 KRTAP2.1A KRTAP2.1B	Homo sapiens (Human)	128	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
Q9BZE3	reviewed	BARH1_HUMAN	BarH-like 1 homeobox protein	BARHL1 FKSG31	Homo sapiens (Human)	327			midbrain development [GO:0030901]; negative regulation of outer hair cell apoptotic process [GO:1905586]; neuron migration [GO:0001764]; outer hair cell apoptotic process [GO:1905584]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; midbrain development [GO:0030901]; negative regulation of outer hair cell apoptotic process [GO:1905586]; neuron migration [GO:0001764]; outer hair cell apoptotic process [GO:1905584]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9BZK3	reviewed	NACP4_HUMAN	Putative nascent polypeptide-associated complex subunit alpha-like protein (Alpha-NAC pseudogene 1) (NAC-alpha pseudogene 1) (NACA family member 4, pseudogene)	NACA4P NACAP1 FKSG17	Homo sapiens (Human)	213			protein targeting to membrane [GO:0006612]	cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]	unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; unfolded protein binding [GO:0051082]; protein targeting to membrane [GO:0006612]	
Q9BZW5	reviewed	TM6S1_HUMAN	Transmembrane 6 superfamily member 1	TM6SF1	Homo sapiens (Human)	370	FUNCTION: May function as sterol isomerase. {ECO:0000303|PubMed:25566323}.			lysosomal membrane [GO:0005765]		lysosomal membrane [GO:0005765]	SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:P58749}; Multi-pass membrane protein {ECO:0000305}.
Q9C0B7	reviewed	TNG6_HUMAN	Transport and Golgi organization protein 6 homolog (Transmembrane and coiled-coil domain-containing protein 7)	TANGO6 KIAA1746 TMCO7	Homo sapiens (Human)	1094			protein secretion [GO:0009306]	membrane [GO:0016020]		membrane [GO:0016020]; protein secretion [GO:0009306]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9C0B9	reviewed	ZCHC2_HUMAN	Zinc finger CCHC domain-containing protein 2	ZCCHC2 C18orf49 KIAA1744	Homo sapiens (Human)	1178				cytoplasm [GO:0005737]	nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270]	
Q9C0D4	reviewed	Z518B_HUMAN	Zinc finger protein 518B	ZNF518B KIAA1729	Homo sapiens (Human)	1074	FUNCTION: Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes. {ECO:0000250|UniProtKB:B2RRE4}.		chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B2RRE4}.
Q9C0H6	reviewed	KLHL4_HUMAN	Kelch-like protein 4	KLHL4 KIAA1687	Homo sapiens (Human)	718				centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]	actin binding [GO:0003779]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; actin binding [GO:0003779]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
Q9C0I3	reviewed	CCSE1_HUMAN	Serine-rich coiled-coil domain-containing protein 1 (Coiled-coil serine-rich protein 1)	CCSER1 FAM190A KIAA1680	Homo sapiens (Human)	900							
Q9C0I9	reviewed	LRC27_HUMAN	Leucine-rich repeat-containing protein 27	LRRC27 KIAA1674	Homo sapiens (Human)	530			cardiac muscle cell development [GO:0055013]	cytoskeleton [GO:0005856]; sarcomere [GO:0030017]	actin binding [GO:0003779]	cytoskeleton [GO:0005856]; sarcomere [GO:0030017]; actin binding [GO:0003779]; cardiac muscle cell development [GO:0055013]	
Q9C0K3	reviewed	ARP3C_HUMAN	Actin-related protein 3C (Actin-related protein 11)	ACTR3C ARP11	Homo sapiens (Human)	210	FUNCTION: May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells. {ECO:0000269|PubMed:11162478}.			extracellular exosome [GO:0070062]	actin binding [GO:0003779]; ATP binding [GO:0005524]	extracellular exosome [GO:0070062]; actin binding [GO:0003779]; ATP binding [GO:0005524]	
Q9GIP4	reviewed	LAT1L_HUMAN	Putative L-type amino acid transporter 1-like protein IMAA (hLAT1 3-transmembrane protein IMAA) (hLAT1 3TM IMAA) (hLAT1 3-transmembrane protein MMAA) (hLAT1 3TM MMAA)	SLC7A5P2 IMAA MMAA	Homo sapiens (Human)	190				membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9GZK3	reviewed	OR2B2_HUMAN	Olfactory receptor 2B2 (Hs6M1-10) (Olfactory receptor 2B9) (Olfactory receptor 6-1) (OR6-1)	OR2B2 OR2B9	Homo sapiens (Human)	357	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9GZK7	reviewed	O11A1_HUMAN	Olfactory receptor 11A1 (Hs6M1-18) (Olfactory receptor 11A2) (Olfactory receptor OR6-30)	OR11A1 OR11A2	Homo sapiens (Human)	315	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9GZM3	reviewed	RPB1B_HUMAN	DNA-directed RNA polymerase II subunit RPB11-b1 (RNA polymerase II subunit B11-b1) (RPB11b1) (DNA-directed RNA polymerase II subunit J2)	POLR2J2	Homo sapiens (Human)	115	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250}.			RNA polymerase II, core complex [GO:0005665]	DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055]	RNA polymerase II, core complex [GO:0005665]; DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9GZN8	reviewed	ADSSP_HUMAN	Adipose-secreted signaling protein	ADISSP C20orf27	Homo sapiens (Human)	174	FUNCTION: Adipocyte-secreted protein (adipokine) that acts as a key regulator for white adipose tissue (WAT) thermogenesis and glucose homeostasis at least in part through activation of protein kinase A (PKA). {ECO:0000250|UniProtKB:Q9D1K7}.		adaptive thermogenesis [GO:1990845]; glucose homeostasis [GO:0042593]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]	extracellular space [GO:0005615]	protein phosphatase 1 binding [GO:0008157]	extracellular space [GO:0005615]; protein phosphatase 1 binding [GO:0008157]; adaptive thermogenesis [GO:1990845]; glucose homeostasis [GO:0042593]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9D1K7}.
Q9GZP1	reviewed	NRSN2_HUMAN	Neurensin-2	NRSN2 C20orf98	Homo sapiens (Human)	204	FUNCTION: May play a role in maintenance and/or transport of vesicles.		nervous system development [GO:0007399]	neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]		neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; nervous system development [GO:0007399]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9GZP8	reviewed	IMUP_HUMAN	Immortalization up-regulated protein (Hepatocyte growth factor activator inhibitor type 2-related small protein) (H2RSP) (HAI-2-related small protein)	IMUP C19orf33	Homo sapiens (Human)	106				cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11080599}.
Q9GZU3	reviewed	TM39B_HUMAN	Transmembrane protein 39B	TMEM39B	Homo sapiens (Human)	492	FUNCTION: May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase. {ECO:0000250|UniProtKB:Q7ZW11}.			endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]		endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7ZW11}; Multi-pass membrane protein {ECO:0000255}.
Q9GZW5	reviewed	SCND2_HUMAN	Putative SCAN domain-containing protein SCAND2P (SCAN domain-containing protein 2 pseudogene)	SCAND2P SCAND2	Homo sapiens (Human)	306		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Q9GZY1	reviewed	PBOV1_HUMAN	Prostate and breast cancer overexpressed gene 1 protein (Protein UROC28) (UC28)	PBOV1 UROC28	Homo sapiens (Human)	135				centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]		centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11156405}. Nucleus {ECO:0000269|PubMed:11156405}.
Q9H0K4	reviewed	RSH6A_HUMAN	Radial spoke head protein 6 homolog A (Radial spoke head-like protein 1)	RSPH6A RSHL1	Homo sapiens (Human)	717	FUNCTION: Functions as part of radial spoke complexes in the axoneme of sperm flagella that play an important part in motility. The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum. {ECO:0000250|UniProtKB:Q8CDR2}.		axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; manchette disassembly [GO:1905199]; sperm flagellum assembly [GO:0120316]	axoneme [GO:0005930]; radial spoke head [GO:0001535]; sperm flagellum [GO:0036126]		axoneme [GO:0005930]; radial spoke head [GO:0001535]; sperm flagellum [GO:0036126]; axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; manchette disassembly [GO:1905199]; sperm flagellum assembly [GO:0120316]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q8CDR2}.
Q9H0M5	reviewed	ZN700_HUMAN	Zinc finger protein 700	ZNF700	Homo sapiens (Human)	742	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H0R4	reviewed	HDHD2_HUMAN	Haloacid dehalogenase-like hydrolase domain-containing protein 2	HDHD2	Homo sapiens (Human)	259			dephosphorylation [GO:0016311]	extracellular exosome [GO:0070062]	enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]	extracellular exosome [GO:0070062]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; dephosphorylation [GO:0016311]	
Q9H114	reviewed	CSTL1_HUMAN	Cystatin-like 1 (RCET11)	CSTL1	Homo sapiens (Human)	145				extracellular region [GO:0005576]	cysteine-type endopeptidase inhibitor activity [GO:0004869]	extracellular region [GO:0005576]; cysteine-type endopeptidase inhibitor activity [GO:0004869]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H195	reviewed	MUC3B_HUMAN	Mucin-3B (MUC-3B) (Intestinal mucin-3B)	MUC3B	Homo sapiens (Human)	13477	FUNCTION: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity). {ECO:0000250}.			Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]		Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9H1A7	reviewed	RPB1C_HUMAN	DNA-directed RNA polymerase II subunit RPB11-b2 (RNA polymerase II subunit B11-b2) (RPB11b2) (DNA-directed RNA polymerase II subunit J3)	POLR2J3	Homo sapiens (Human)	115	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250}.			RNA polymerase II, core complex [GO:0005665]	DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055]	RNA polymerase II, core complex [GO:0005665]; DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9H1C3	reviewed	GL8D2_HUMAN	Glycosyltransferase 8 domain-containing protein 2 (EC 2.4.1.-)	GLT8D2 GALA4A UNQ1901/PRO4347	Homo sapiens (Human)	349			organic substance metabolic process [GO:0071704]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	UDP-glycosyltransferase activity [GO:0008194]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; UDP-glycosyltransferase activity [GO:0008194]; organic substance metabolic process [GO:0071704]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q9H1C7	reviewed	CYTM1_HUMAN	Cysteine-rich and transmembrane domain-containing protein 1	CYSTM1 C5orf32 ORF1-FL49	Homo sapiens (Human)	97				extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]		extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9H1E5	reviewed	TMX4_HUMAN	Thioredoxin-related transmembrane protein 4 (Thioredoxin domain-containing protein 13)	TMX4 KIAA1162 TXNDC13 PSEC0095 UNQ475/PRO938	Homo sapiens (Human)	349				endomembrane system [GO:0012505]; nuclear inner membrane [GO:0005637]	disulfide oxidoreductase activity [GO:0015036]	endomembrane system [GO:0012505]; nuclear inner membrane [GO:0005637]; disulfide oxidoreductase activity [GO:0015036]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:Q8C0L0}; Single-pass type I membrane protein {ECO:0000255}.
Q9H1H1	reviewed	GTSFL_HUMAN	Gametocyte-specific factor 1-like (Protein FAM112A)	GTSF1L C20orf65 FAM112A	Homo sapiens (Human)	148					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q9H1K6	reviewed	TLRN1_HUMAN	Talin rod domain-containing protein 1 (Mesoderm development candidate 1)	TLNRD1 MESDC1	Homo sapiens (Human)	362	FUNCTION: Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. {ECO:0000269|PubMed:22179486}.			stress fiber [GO:0001725]	actin binding [GO:0003779]; identical protein binding [GO:0042802]	stress fiber [GO:0001725]; actin binding [GO:0003779]; identical protein binding [GO:0042802]	
Q9H1M0	reviewed	N62CL_HUMAN	Nucleoporin-62 C-terminal-like protein	NUP62CL NUP62L	Homo sapiens (Human)	184			protein transport [GO:0015031]	nuclear pore [GO:0005643]	structural constituent of nuclear pore [GO:0017056]	nuclear pore [GO:0005643]; structural constituent of nuclear pore [GO:0017056]; protein transport [GO:0015031]	
Q9H1M3	reviewed	DB129_HUMAN	Beta-defensin 129 (Beta-defensin 29) (DEFB-29) (Defensin, beta 129)	DEFB129 C20orf87 DEFB29 UNQ5794/PRO19599	Homo sapiens (Human)	183	FUNCTION: Has antibacterial activity. {ECO:0000305}.		defense response to bacterium [GO:0042742]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H1Q7	reviewed	PED1A_HUMAN	PC-esterase domain-containing protein 1A (Protein FAM113A) (Sarcoma antigen NY-SAR-23)	PCED1A C20orf81 FAM113A	Homo sapiens (Human)	454					transferase activity [GO:0016740]	transferase activity [GO:0016740]	
Q9H1Z4	reviewed	WDR13_HUMAN	WD repeat-containing protein 13	WDR13	Homo sapiens (Human)	485			negative regulation of type B pancreatic cell proliferation [GO:1904691]	centriolar satellite [GO:0034451]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	promoter-specific chromatin binding [GO:1990841]	centriolar satellite [GO:0034451]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; promoter-specific chromatin binding [GO:1990841]; negative regulation of type B pancreatic cell proliferation [GO:1904691]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12659815}.
Q9H2C5	reviewed	O52A5_HUMAN	Olfactory receptor 52A5 (Odorant receptor HOR3'beta5) (Olfactory receptor OR11-33)	OR52A5	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H2C8	reviewed	O51V1_HUMAN	Olfactory receptor 51V1 (Odorant receptor HOR3'beta1) (Olfactory receptor 51A12) (Olfactory receptor OR11-36)	OR51V1 OR51A12	Homo sapiens (Human)	321	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H2I8	reviewed	LRMDA_HUMAN	Leucine-rich melanocyte differentiation-associated protein	LRMDA C10orf11 CDA017	Homo sapiens (Human)	198	FUNCTION: Required for melanocyte differentiation. {ECO:0000269|PubMed:23395477}.		melanocyte differentiation [GO:0030318]			melanocyte differentiation [GO:0030318]	
Q9H2Z4	reviewed	NKX24_HUMAN	Homeobox protein Nkx-2.4 (Homeobox protein NK-2 homolog D)	NKX2-4 NKX2D	Homo sapiens (Human)	354	FUNCTION: Probable transcription factor.		cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q9H321	reviewed	VCX3B_HUMAN	Variable charge X-linked protein 3B (Variably charged protein X-C) (VCX-C)	VCX3B VCXC	Homo sapiens (Human)	246	FUNCTION: May mediate a process in spermatogenesis or may play a role in sex ratio distortion.		brain development [GO:0007420]	nucleolus [GO:0005730]; nucleus [GO:0005634]		nucleolus [GO:0005730]; nucleus [GO:0005634]; brain development [GO:0007420]	
Q9H322	reviewed	VCX2_HUMAN	Variable charge X-linked protein 2 (Variable charge protein on X with two repeats) (VCX-2r) (Variably charged protein X-B) (VCX-B)	VCX2 VCX2R VCXB	Homo sapiens (Human)	139	FUNCTION: May mediate a process in spermatogenesis or may play a role in sex ratio distortion.		brain development [GO:0007420]			brain development [GO:0007420]	
Q9H343	reviewed	O51I1_HUMAN	Olfactory receptor 51I1 (Odorant receptor HOR5'beta11) (Olfactory receptor OR11-39)	OR51I1	Homo sapiens (Human)	314	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H344	reviewed	O51I2_HUMAN	Olfactory receptor 51I2 (Odorant receptor HOR5'beta12) (Olfactory receptor OR11-38)	OR51I2	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H346	reviewed	O52D1_HUMAN	Olfactory receptor 52D1 (Odorant receptor HOR5'beta14) (Olfactory receptor OR11-43)	OR52D1	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9H3H9	reviewed	TCAL2_HUMAN	Transcription elongation factor A protein-like 2 (TCEA-like protein 2) (Transcription elongation factor S-II protein-like 2)	TCEAL2 My048 MY0876G0	Homo sapiens (Human)	227	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H3V2	reviewed	MS4A5_HUMAN	Membrane-spanning 4-domains subfamily A member 5 (CD20 antigen-like 2) (Testis-expressed transmembrane protein 4)	MS4A5 CD20L2 TETM4	Homo sapiens (Human)	200	FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex.		cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9H3W5	reviewed	LRRN3_HUMAN	Leucine-rich repeat neuronal protein 3 (Neuronal leucine-rich repeat protein 3) (NLRR-3)	LRRN3 Nbla10363 UNQ194/PRO220	Homo sapiens (Human)	708			positive regulation of synapse assembly [GO:0051965]	extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]		extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; positive regulation of synapse assembly [GO:0051965]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9H3Y0	reviewed	CRSPL_HUMAN	Peptidase inhibitor R3HDML (Cysteine-rich secretory protein R3HDML)	R3HDML	Homo sapiens (Human)	253	FUNCTION: Putative serine protease inhibitor. {ECO:0000250}.			extracellular space [GO:0005615]	peptidase inhibitor activity [GO:0030414]	extracellular space [GO:0005615]; peptidase inhibitor activity [GO:0030414]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H3Z7	reviewed	ABHGB_HUMAN	Protein ABHD16B (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 16B) (Abhydrolase domain-containing protein 16B)	ABHD16B C20orf135	Homo sapiens (Human)	469			monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]	nucleoplasm [GO:0005654]	acylglycerol lipase activity [GO:0047372]; phospholipase activity [GO:0004620]	nucleoplasm [GO:0005654]; acylglycerol lipase activity [GO:0047372]; phospholipase activity [GO:0004620]; monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]	
Q9H425	reviewed	CA198_HUMAN	Uncharacterized protein C1orf198	C1orf198	Homo sapiens (Human)	327				cytosol [GO:0005829]		cytosol [GO:0005829]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22361696}.
Q9H4I0	reviewed	RD21L_HUMAN	Double-strand-break repair protein rad21-like protein 1	RAD21L1 RAD21L	Homo sapiens (Human)	556	FUNCTION: Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity). {ECO:0000250}.		chromosome segregation [GO:0007059]; meiotic cell cycle [GO:0051321]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; sister chromatid cohesion [GO:0007062]	chromosome [GO:0005694]; cohesin complex [GO:0008278]; meiotic cohesin complex [GO:0030893]; nucleus [GO:0005634]	chromatin binding [GO:0003682]	chromosome [GO:0005694]; cohesin complex [GO:0008278]; meiotic cohesin complex [GO:0030893]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; chromosome segregation [GO:0007059]; meiotic cell cycle [GO:0051321]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; sister chromatid cohesion [GO:0007062]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A2AU37}. Chromosome {ECO:0000250|UniProtKB:A2AU37}. Note=In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements. {ECO:0000250|UniProtKB:A2AU37}.
Q9H4K1	reviewed	RIBC2_HUMAN	RIB43A-like with coiled-coils protein 2	RIBC2 C22orf11	Homo sapiens (Human)	382	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.			axonemal microtubule [GO:0005879]; nucleus [GO:0005634]		axonemal microtubule [GO:0005879]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q9H568	reviewed	ACTL8_HUMAN	Actin-like protein 8 (Cancer/testis antigen 57) (CT57)	ACTL8	Homo sapiens (Human)	366			epithelial cell differentiation [GO:0030855]; skeletal muscle thin filament assembly [GO:0030240]	actin filament [GO:0005884]; stress fiber [GO:0001725]; striated muscle thin filament [GO:0005865]		actin filament [GO:0005884]; stress fiber [GO:0001725]; striated muscle thin filament [GO:0005865]; epithelial cell differentiation [GO:0030855]; skeletal muscle thin filament assembly [GO:0030240]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q9H5J0	reviewed	ZBTB3_HUMAN	Zinc finger and BTB domain-containing protein 3	ZBTB3	Homo sapiens (Human)	574	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H628	reviewed	RERGL_HUMAN	Ras-related and estrogen-regulated growth inhibitor-like protein (EC 3.6.5.2) (RERG/Ras-like protein)	RERGL	Homo sapiens (Human)	205	FUNCTION: Binds GDP/GTP and may possess intrinsic GTPase activity. {ECO:0000250}.				G protein activity [GO:0003925]; GTP binding [GO:0005525]	G protein activity [GO:0003925]; GTP binding [GO:0005525]	
Q9H6A0	reviewed	DEN2D_HUMAN	DENN domain-containing protein 2D	DENND2D	Homo sapiens (Human)	471	FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.			cytosol [GO:0005829]; nucleoplasm [GO:0005654]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; guanyl-nucleotide exchange factor activity [GO:0005085]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23182661}.
Q9H6B1	reviewed	Z385D_HUMAN	Zinc finger protein 385D (Zinc finger protein 659)	ZNF385D ZNF659	Homo sapiens (Human)	395				nucleus [GO:0005634]	sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H6Y2	reviewed	WDR55_HUMAN	WD repeat-containing protein 55	WDR55	Homo sapiens (Human)	383	FUNCTION: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). {ECO:0000250}.		rRNA processing [GO:0006364]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; rRNA processing [GO:0006364]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Q9H6Y5	reviewed	MAGIX_HUMAN	PDZ domain-containing protein MAGIX	MAGIX	Homo sapiens (Human)	334							
Q9H720	reviewed	PG2IP_HUMAN	PGAP2-interacting protein (Cell wall biogenesis protein 43 C-terminal homolog)	CWH43 PGAP2IP	Homo sapiens (Human)	699	FUNCTION: Involved in lipid remodeling during GPI-anchor maturation. {ECO:0000250}.			endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]		endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9H765	reviewed	ASB8_HUMAN	Ankyrin repeat and SOCS box protein 8 (ASB-8)	ASB8 PP14212	Homo sapiens (Human)	288	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]		cytosol [GO:0005829]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12559969}.
Q9H7J1	reviewed	PPR3E_HUMAN	Protein phosphatase 1 regulatory subunit 3E	PPP1R3E	Homo sapiens (Human)	279	FUNCTION: Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis. {ECO:0000269|PubMed:15752363}.		glycogen metabolic process [GO:0005977]; positive regulation of glycogen biosynthetic process [GO:0045725]; regulation of glycogen biosynthetic process [GO:0005979]	glycogen granule [GO:0042587]; protein phosphatase type 1 complex [GO:0000164]	[phosphorylase] phosphatase activity [GO:0050196]; glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]	glycogen granule [GO:0042587]; protein phosphatase type 1 complex [GO:0000164]; [phosphorylase] phosphatase activity [GO:0050196]; glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; glycogen metabolic process [GO:0005977]; positive regulation of glycogen biosynthetic process [GO:0045725]; regulation of glycogen biosynthetic process [GO:0005979]	
Q9H7L2	reviewed	KI3X1_HUMAN	Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 (Leukocyte receptor cluster member 12)	KIR3DX1 KIR3DL0 LENG12	Homo sapiens (Human)	352				extracellular region [GO:0005576]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H7R5	reviewed	ZN665_HUMAN	Zinc finger protein 665 (Zinc finger protein 160-like)	ZNF665 ZFP160L	Homo sapiens (Human)	678	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H7X2	reviewed	RDD1_HUMAN	Required for drug-induced death protein 1	C1orf115 RDD1	Homo sapiens (Human)	142	FUNCTION: Regulates drug efflux through modulation of ABCB1 localization and activity. {ECO:0000269|PubMed:32028983, ECO:0000269|PubMed:35970996}.		regulation of response to drug [GO:2001023]	9+0 non-motile cilium [GO:0097731]; membrane [GO:0016020]		9+0 non-motile cilium [GO:0097731]; membrane [GO:0016020]; regulation of response to drug [GO:2001023]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Q9H7Y0	reviewed	DIK2B_HUMAN	Divergent protein kinase domain 2B (Deleted in autism-related protein 1)	DIPK2B CXorf36 DIA1R UNQ1862/PRO3743	Homo sapiens (Human)	433				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H819	reviewed	DJC18_HUMAN	DnaJ homolog subfamily C member 18	DNAJC18	Homo sapiens (Human)	358	FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:25631089). Regulates the recruitment of DNAJB12:DNAJB14 into SV40-induced foci and all cooperate to guide SV40 across the endoplasmic reticulum membrane. The foci represent the site from which SV40 penetrates into the cytosol (PubMed:25631089). {ECO:0000269|PubMed:25631089}.		cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]	endoplasmic reticulum membrane [GO:0005789]	Hsp70 protein binding [GO:0030544]	endoplasmic reticulum membrane [GO:0005789]; Hsp70 protein binding [GO:0030544]; cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25631089}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Note=(Microbial infection) Upon SV40 infection, colocalizes with BCAP31, DNAJB12 and DNAJB14 in punctate structures within the endoplasmic reticulum membrane. {ECO:0000269|PubMed:25631089}.
Q9H841	reviewed	NPAL2_HUMAN	NIPA-like protein 2	NIPAL2 NPAL2	Homo sapiens (Human)	383			magnesium ion transport [GO:0015693]	membrane [GO:0016020]	magnesium ion transmembrane transporter activity [GO:0015095]	membrane [GO:0016020]; magnesium ion transmembrane transporter activity [GO:0015095]; magnesium ion transport [GO:0015693]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9H853	reviewed	TBA4B_HUMAN	Putative tubulin-like protein alpha-4B (EC 3.6.5.-) (Alpha-tubulin 4B)	TUBA4B TUBA4	Homo sapiens (Human)	241			microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	cytoplasm [GO:0005737]; microtubule [GO:0005874]	GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
Q9H857	reviewed	NT5D2_HUMAN	5'-nucleotidase domain-containing protein 2 (EC 3.1.3.-)	NT5DC2	Homo sapiens (Human)	520					5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]	5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]	
Q9H8G1	reviewed	ZN430_HUMAN	Zinc finger protein 430	ZNF430	Homo sapiens (Human)	570	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]; substantia nigra development [GO:0021762]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]; substantia nigra development [GO:0021762]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H8G2	reviewed	CAAP1_HUMAN	Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP)	CAAP1 C9orf82 CAAP	Homo sapiens (Human)	361	FUNCTION: Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}.		apoptotic process [GO:0006915]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]			apoptotic process [GO:0006915]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]	
Q9H8M1	reviewed	CQ10B_HUMAN	Coenzyme Q-binding protein COQ10 homolog B, mitochondrial	COQ10B	Homo sapiens (Human)	238	FUNCTION: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity). {ECO:0000250}.		cellular respiration [GO:0045333]; ubiquinone biosynthetic process [GO:0006744]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	ubiquinone binding [GO:0048039]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ubiquinone binding [GO:0048039]; cellular respiration [GO:0045333]; ubiquinone biosynthetic process [GO:0006744]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Q9H8U3	reviewed	ZFAN3_HUMAN	AN1-type zinc finger protein 3 (Testis-expressed protein 27)	ZFAND3 TEX27	Homo sapiens (Human)	227					DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	DNA binding [GO:0003677]; zinc ion binding [GO:0008270]	
Q9H930	reviewed	SP14L_HUMAN	Nuclear body protein SP140-like protein	SP140L	Homo sapiens (Human)	580			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q9H939	reviewed	PPIP2_HUMAN	Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2)	PSTPIP2	Homo sapiens (Human)	334	FUNCTION: Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity). {ECO:0000250}.		actin filament polymerization [GO:0030041]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	actin filament binding [GO:0051015]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; actin filament polymerization [GO:0030041]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Q9H963	reviewed	ZN702_HUMAN	Putative zinc finger protein 702	ZNF702P ZNF702	Homo sapiens (Human)	129	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9H972	reviewed	CN093_HUMAN	Uncharacterized protein C14orf93	C14orf93	Homo sapiens (Human)	538			cell differentiation [GO:0030154]; positive regulation of gene expression [GO:0010628]	extracellular region [GO:0005576]	RNA binding [GO:0003723]	extracellular region [GO:0005576]; RNA binding [GO:0003723]; cell differentiation [GO:0030154]; positive regulation of gene expression [GO:0010628]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H9L3	reviewed	I20L2_HUMAN	Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-)	ISG20L2 HSD-38 HSD38	Homo sapiens (Human)	353	FUNCTION: 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group. {ECO:0000269|PubMed:18065403}.		ribosome biogenesis [GO:0042254]	nucleolus [GO:0005730]; nucleus [GO:0005634]	3'-5'-RNA exonuclease activity [GO:0000175]; exonuclease activity [GO:0004527]; RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleus [GO:0005634]; 3'-5'-RNA exonuclease activity [GO:0000175]; exonuclease activity [GO:0004527]; RNA binding [GO:0003723]; ribosome biogenesis [GO:0042254]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:18065403}.
Q9H9S3	reviewed	S61A2_HUMAN	Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2)	SEC61A2	Homo sapiens (Human)	476	FUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. {ECO:0000250|UniProtKB:P61619}.		post-translational protein targeting to membrane, translocation [GO:0031204]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	Sec61 translocon complex [GO:0005784]	protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022]; signal sequence binding [GO:0005048]	Sec61 translocon complex [GO:0005784]; protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022]; signal sequence binding [GO:0005048]; post-translational protein targeting to membrane, translocation [GO:0031204]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P61619}; Multi-pass membrane protein {ECO:0000255}.
Q9H9S4	reviewed	CB39L_HUMAN	Calcium-binding protein 39-like (Antigen MLAA-34) (MO25beta) (Mo25-like protein)	CAB39L	Homo sapiens (Human)	337	FUNCTION: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Found in serum of 50% of patients with acute monocytic leukemia.	intracellular signal transduction [GO:0035556]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; serine/threonine protein kinase complex [GO:1902554]	protein serine/threonine kinase activator activity [GO:0043539]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; serine/threonine protein kinase complex [GO:1902554]; protein serine/threonine kinase activator activity [GO:0043539]; intracellular signal transduction [GO:0035556]	
Q9H9Y4	reviewed	GPN2_HUMAN	GPN-loop GTPase 2 (ATP-binding domain 1 family member B)	GPN2 ATPBD1B UNQ5828/PRO19647	Homo sapiens (Human)	310	FUNCTION: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. {ECO:0000250|UniProtKB:Q08726}.				GTP binding [GO:0005525]; GTPase activity [GO:0003924]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	
Q9HA72	reviewed	CAHM2_HUMAN	Calcium homeostasis modulator protein 2 (Protein FAM26B)	CALHM2 FAM26B	Homo sapiens (Human)	323	FUNCTION: Pore-forming subunit of a voltage-gated ion channel. {ECO:0000250|UniProtKB:Q8IU99}.		positive regulation of apoptotic process [GO:0043065]	membrane [GO:0016020]	monoatomic cation channel activity [GO:0005261]	membrane [GO:0016020]; monoatomic cation channel activity [GO:0005261]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9HA90	reviewed	EFCC1_HUMAN	EF-hand and coiled-coil domain-containing protein 1 (Coiled-coil domain-containing protein 48)	EFCC1 C3orf73 CCDC48	Homo sapiens (Human)	598					calcium ion binding [GO:0005509]	calcium ion binding [GO:0005509]	
Q9HAE3	reviewed	CLXN_HUMAN	Calaxin (EF-hand calcium-binding domain-containing protein 1)	CLXN EFCAB1	Homo sapiens (Human)	211	FUNCTION: Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Seems to regulate the assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). Regulates ciliary and flagellar motility and is required for cilia-driven determination of body laterality (By similarity). {ECO:0000250|UniProtKB:Q32L26, ECO:0000250|UniProtKB:Q9D3N2}.		cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]; regulation of cilium movement [GO:0003352]; regulation of flagellated sperm motility [GO:1901317]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	calcium ion binding [GO:0005509]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; calcium ion binding [GO:0005509]; cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]; regulation of cilium movement [GO:0003352]; regulation of flagellated sperm motility [GO:1901317]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q96M63}.
Q9HAH1	reviewed	ZN556_HUMAN	Zinc finger protein 556	ZNF556	Homo sapiens (Human)	456	FUNCTION: May be involved in transcriptional regulation.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9HB14	reviewed	KCNKD_HUMAN	Potassium channel subfamily K member 13 (Tandem pore domain halothane-inhibited potassium channel 1) (THIK-1)	KCNK13	Homo sapiens (Human)	408	FUNCTION: Potassium channel displaying weak inward rectification in symmetrical K(+) solution. {ECO:0000250}.	MISCELLANEOUS: The current is enhanced by arachidonic acid and inhibited by halothane. {ECO:0000250}.	potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]; stabilization of membrane potential [GO:0030322]	plasma membrane [GO:0005886]	outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]; outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9HB15	reviewed	KCNKC_HUMAN	Potassium channel subfamily K member 12 (Tandem pore domain halothane-inhibited potassium channel 2) (THIK-2)	KCNK12	Homo sapiens (Human)	430	FUNCTION: Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity). {ECO:0000250}.		potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]; stabilization of membrane potential [GO:0030322]	membrane [GO:0016020]	outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]	membrane [GO:0016020]; outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]; potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transmembrane transport [GO:0034765]; stabilization of membrane potential [GO:0030322]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9HB31	reviewed	SEBOX_HUMAN	Homeobox protein SEBOX (Homeobox OG-9) (Skin-, embryo-, brain- and oocyte-specific homeobox)	SEBOX OG9X	Homo sapiens (Human)	190	FUNCTION: Probable transcription factor involved in the control of specification of mesoderm and endoderm. {ECO:0000250}.		embryo development ending in birth or egg hatching [GO:0009792]; oogenesis [GO:0048477]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; embryo development ending in birth or egg hatching [GO:0009792]; oogenesis [GO:0048477]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q9HBJ0	reviewed	PLAC1_HUMAN	Placenta-specific protein 1	PLAC1	Homo sapiens (Human)	212	FUNCTION: May play a role in placental development. {ECO:0000269|PubMed:10995572}.		placenta development [GO:0001890]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; placenta development [GO:0001890]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9HBL7	reviewed	PLRKT_HUMAN	Plasminogen receptor (KT) (Plg-R(KT))	PLGRKT C9orf46 AD025 MDS030	Homo sapiens (Human)	147	FUNCTION: Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9. {ECO:0000269|PubMed:21940822}.		chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; positive regulation of plasminogen activation [GO:0010756]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; positive regulation of plasminogen activation [GO:0010756]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21940822}; Multi-pass membrane protein {ECO:0000269|PubMed:21940822}. Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR. {ECO:0000250}.
Q9HBT7	reviewed	ZN287_HUMAN	Zinc finger protein 287 (Zinc finger protein with KRAB and SCAN domains 13)	ZNF287 ZKSCAN13	Homo sapiens (Human)	761	FUNCTION: May be involved in transcriptional regulation.		positive regulation of DNA-templated transcription [GO:0045893]; regulation of cytokine production [GO:0001817]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cytokine production [GO:0001817]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9HC44	reviewed	GPBL1_HUMAN	Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1)	GPBP1L1 SP192	Homo sapiens (Human)	474	FUNCTION: Possible transcription factor. {ECO:0000305}.		DNA-templated transcription [GO:0006351]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA binding [GO:0003677]; RNA binding [GO:0003723]	nucleus [GO:0005634]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; DNA-templated transcription [GO:0006351]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9HC57	reviewed	WFDC1_HUMAN	WAP four-disulfide core domain protein 1 (Prostate stromal protein ps20) (ps20 growth inhibitor)	WFDC1 PS20	Homo sapiens (Human)	220	FUNCTION: Has growth inhibitory activity. {ECO:0000250}.		negative regulation of cell growth [GO:0030308]; negative regulation of inflammatory response [GO:0050728]; negative regulation of wound healing [GO:0061045]; regulation of cell growth [GO:0001558]	extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of cell growth [GO:0030308]; negative regulation of inflammatory response [GO:0050728]; negative regulation of wound healing [GO:0061045]; regulation of cell growth [GO:0001558]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9HCE3	reviewed	ZN532_HUMAN	Zinc finger protein 532	ZNF532 KIAA1629	Homo sapiens (Human)	1301	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9HCJ3	reviewed	RAVR2_HUMAN	Ribonucleoprotein PTB-binding 2 (Protein raver-2)	RAVER2 KIAA1579	Homo sapiens (Human)	691	FUNCTION: May bind single-stranded nucleic acids. {ECO:0000305}.			cytoplasm [GO:0005737]; nucleus [GO:0005634]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=May shuttle between the nucleus and the cytoplasm. {ECO:0000250}.
Q9HCJ5	reviewed	ZSWM6_HUMAN	Zinc finger SWIM domain-containing protein 6	ZSWIM6 KIAA1577	Homo sapiens (Human)	1215	FUNCTION: involved in nervous system development, important for striatal morphology and motor regulation. {ECO:0000250|UniProtKB:Q80TB7}.		striatal medium spiny neuron differentiation [GO:0021773]	Cul2-RING ubiquitin ligase complex [GO:0031462]	zinc ion binding [GO:0008270]	Cul2-RING ubiquitin ligase complex [GO:0031462]; zinc ion binding [GO:0008270]; striatal medium spiny neuron differentiation [GO:0021773]	
Q9HCJ6	reviewed	VAT1L_HUMAN	Synaptic vesicle membrane protein VAT-1 homolog-like (EC 1.-.-.-)	VAT1L KIAA1576	Homo sapiens (Human)	419					oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270]	oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270]	
Q9HCK1	reviewed	ZDBF2_HUMAN	DBF4-type zinc finger-containing protein 2	ZDBF2 KIAA1571	Homo sapiens (Human)	2354			genomic imprinting [GO:0071514]; post-fertilization epigenetic regulation of gene expression [GO:0043045]	nucleus [GO:0005634]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; genomic imprinting [GO:0071514]; post-fertilization epigenetic regulation of gene expression [GO:0043045]	
Q9HCL3	reviewed	ZFP14_HUMAN	Zinc finger protein 14 homolog (Zfp-14) (Zinc finger protein 531)	ZFP14 KIAA1559 ZNF531	Homo sapiens (Human)	533	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9HCM7	reviewed	FBSL_HUMAN	Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9)	FBRSL1 AUTS2L KIAA1545 XTP9	Homo sapiens (Human)	1045					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q9HCS5	reviewed	E41LA_HUMAN	Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4)	EPB41L4A EPB41L4	Homo sapiens (Human)	686			actomyosin structure organization [GO:0031032]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	cytoskeletal protein binding [GO:0008092]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytoskeletal protein binding [GO:0008092]; actomyosin structure organization [GO:0031032]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q9HCZ1	reviewed	ZN334_HUMAN	Zinc finger protein 334	ZNF334	Homo sapiens (Human)	680	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9HD45	reviewed	TM9S3_HUMAN	Transmembrane 9 superfamily member 3 (EP70-P-iso) (SM-11044-binding protein)	TM9SF3 SMBP UNQ245/PRO282	Homo sapiens (Human)	589			protein localization to membrane [GO:0072657]	membrane [GO:0016020]		membrane [GO:0016020]; protein localization to membrane [GO:0072657]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9HDB8	reviewed	ENK5_HUMAN	Endogenous retrovirus group K member 5 Env polyprotein (Envelope polyprotein) (HERV-K(II) envelope protein) (HERV-K_3q12.3 provirus ancestral Env polyprotein) [Includes: Truncated surface protein (SU)]	ERVK-5 ERVK5	Homo sapiens (Human)	245	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.	MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.; MISCELLANEOUS: Intergenic, closest flanking genes being RPL24 and FLJ23047.					SUBCELLULAR LOCATION: Virion.
Q9NNX9	reviewed	VCX3_HUMAN	Variable charge X-linked protein 3 (Variable charge protein on X with eight repeats) (VCX-8r) (Variably charged protein X-A) (VCX-A)	VCX3A VCX3 VCX8R VCXA	Homo sapiens (Human)	186	FUNCTION: May mediate a process in spermatogenesis or may play a role in sex ratio distortion.		brain development [GO:0007420]	nucleolus [GO:0005730]; nucleus [GO:0005634]		nucleolus [GO:0005730]; nucleus [GO:0005634]; brain development [GO:0007420]	
Q9NNZ3	reviewed	DNJC4_HUMAN	DnaJ homolog subfamily C member 4 (DnaJ-like protein HSPF2) (Multiple endocrine neoplasia type 1 candidate protein number 18)	DNAJC4 HSPF2 MCG18	Homo sapiens (Human)	241			protein folding [GO:0006457]; response to unfolded protein [GO:0006986]	membrane [GO:0016020]	unfolded protein binding [GO:0051082]	membrane [GO:0016020]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NNZ6	reviewed	PRM3_HUMAN	Protamine-3 (Sperm protamine P3)	PRM3	Homo sapiens (Human)	103	FUNCTION: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity). {ECO:0000250}.		cell differentiation [GO:0030154]; chromosome condensation [GO:0030261]; flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]	cytoplasm [GO:0005737]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; cell differentiation [GO:0030154]; chromosome condensation [GO:0030261]; flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Q9NPD7	reviewed	NRN1_HUMAN	Neuritin	NRN1 NRN	Homo sapiens (Human)	142	FUNCTION: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. {ECO:0000250}.		neuron projection extension [GO:1990138]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]; neuron projection extension [GO:1990138]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Synapse {ECO:0000250}.
Q9NPI7	reviewed	KRCC1_HUMAN	Lysine-rich coiled-coil protein 1 (Cryptogenic hepatitis-binding protein 2)	KRCC1 CHBP2 BM-003 BM-044	Homo sapiens (Human)	259							
Q9NQ35	reviewed	NRIP3_HUMAN	Nuclear receptor-interacting protein 3 (Sarcoma antigen NY-SAR-105)	NRIP3 C11orf14	Homo sapiens (Human)	241			proteolysis [GO:0006508]		aspartic-type endopeptidase activity [GO:0004190]	aspartic-type endopeptidase activity [GO:0004190]; proteolysis [GO:0006508]	
Q9NQ89	reviewed	CL004_HUMAN	Protein C12orf4	C12orf4	Homo sapiens (Human)	552	FUNCTION: Plays a role in mast cell degranulation. {ECO:0000250|UniProtKB:D4A770}.		regulation of mast cell degranulation [GO:0043304]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; regulation of mast cell degranulation [GO:0043304]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:D4A770}.
Q9NQF3	reviewed	SERHL_HUMAN	Serine hydrolase-like protein (SHL) (EC 3.1.-.-)	SERHL SERHL2	Homo sapiens (Human)	203	FUNCTION: Putative serine hydrolase.	MISCELLANEOUS: This gene may have been partially duplicated (see SERHL2).			hydrolase activity [GO:0016787]	hydrolase activity [GO:0016787]	
Q9NQX6	reviewed	ZN331_HUMAN	Zinc finger protein 331 (C2H2-like zinc finger protein rearranged in thyroid adenomas) (Zinc finger protein 361) (Zinc finger protein 463)	ZNF331 RITA ZNF361 ZNF463	Homo sapiens (Human)	463	FUNCTION: May be involved in transcriptional regulation. May play a role in spermatogenesis.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NRC9	reviewed	OTOR_HUMAN	Otoraplin (Fibrocyte-derived protein) (Melanoma inhibitory activity-like protein)	OTOR FDP MIAL UNQ3054/PRO9873	Homo sapiens (Human)	128			cartilage condensation [GO:0001502]; sensory perception of sound [GO:0007605]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; cartilage condensation [GO:0001502]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9NRD0	reviewed	FBX8_HUMAN	F-box only protein 8 (F-box/SEC7 protein FBS)	FBXO8 FBS FBX8 DC10 UNQ1877/PRO4320	Homo sapiens (Human)	319	FUNCTION: May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential). {ECO:0000305}.		regulation of ARF protein signal transduction [GO:0032012]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin ligase complex [GO:0000151]	guanyl-nucleotide exchange factor activity [GO:0005085]	ubiquitin ligase complex [GO:0000151]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of ARF protein signal transduction [GO:0032012]; ubiquitin-dependent protein catabolic process [GO:0006511]	
Q9NRP2	reviewed	COXM2_HUMAN	COX assembly mitochondrial protein 2 homolog	CMC2 C16orf61 DC13	Homo sapiens (Human)	79	FUNCTION: May be involved in cytochrome c oxidase biogenesis. {ECO:0000250}.			mitochondrion [GO:0005739]		mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20220131}.
Q9NS67	reviewed	GPR27_HUMAN	Probable G-protein coupled receptor 27 (Super conserved receptor expressed in brain 1)	GPR27 SREB1	Homo sapiens (Human)	375	FUNCTION: Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.		positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9NS85	reviewed	CAH10_HUMAN	Carbonic anhydrase-related protein 10 (Carbonic anhydrase-related protein X) (CA-RP X) (CARP X) (Cerebral protein 15)	CA10 hucep-15 UNQ533/PRO1076	Homo sapiens (Human)	328	FUNCTION: Does not have a catalytic activity.		brain development [GO:0007420]; one-carbon metabolic process [GO:0006730]		carbonate dehydratase activity [GO:0004089]; hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270]	carbonate dehydratase activity [GO:0004089]; hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270]; brain development [GO:0007420]; one-carbon metabolic process [GO:0006730]	
Q9NSJ1	reviewed	Z355P_HUMAN	Putative zinc finger protein 355P (Zinc finger protein ZnFP01)	ZNF355P ZNF834 PRED65	Homo sapiens (Human)	428	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NSY2	reviewed	STAR5_HUMAN	StAR-related lipid transfer protein 5 (START domain-containing protein 5) (StARD5)	STARD5	Homo sapiens (Human)	213	FUNCTION: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity). {ECO:0000250}.		cholesterol import [GO:0070508]	cytosol [GO:0005829]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]	cytosol [GO:0005829]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; cholesterol import [GO:0070508]	
Q9NU23	reviewed	LYRM2_HUMAN	LYR motif-containing protein 2	LYRM2	Homo sapiens (Human)	88	FUNCTION: Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I. {ECO:0000269|PubMed:31666358}.		mitochondrial respiratory chain complex I assembly [GO:0032981]	mitochondrion [GO:0005739]		mitochondrion [GO:0005739]; mitochondrial respiratory chain complex I assembly [GO:0032981]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:31666358}.
Q9NUG4	reviewed	CCM2L_HUMAN	Cerebral cavernous malformations 2 protein-like (CCM2-like)	CCM2L C20orf160	Homo sapiens (Human)	571			heart morphogenesis [GO:0003007]			heart morphogenesis [GO:0003007]	
Q9NV39	reviewed	PRR34_HUMAN	Proline-rich protein 34	PRR34 C22orf26	Homo sapiens (Human)	138							
Q9NVA4	reviewed	T184C_HUMAN	Transmembrane protein 184C (Transmembrane protein 34)	TMEM184C TMEM34 PRO1355	Homo sapiens (Human)	438	FUNCTION: Possible tumor suppressor which may play a role in cell growth. {ECO:0000269|PubMed:17072649}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NVE4	reviewed	CCD87_HUMAN	Coiled-coil domain-containing protein 87	CCDC87	Homo sapiens (Human)	849	FUNCTION: Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility. {ECO:0000250|UniProtKB:Q8CDL9}.		cell differentiation [GO:0030154]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of fertilization [GO:1905516]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]			cell differentiation [GO:0030154]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of fertilization [GO:1905516]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]	
Q9NVM1	reviewed	EVA1B_HUMAN	Protein eva-1 homolog B (Protein FAM176B)	EVA1B C1orf78 FAM176B	Homo sapiens (Human)	165				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NVR0	reviewed	KLH11_HUMAN	Kelch-like protein 11	KLHL11	Homo sapiens (Human)	708	FUNCTION: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. {ECO:0000250}.			cytosol [GO:0005829]		cytosol [GO:0005829]	
Q9NW07	reviewed	ZN358_HUMAN	Zinc finger protein 358	ZNF358	Homo sapiens (Human)	568	FUNCTION: May be involved in transcriptional regulation.		embryonic forelimb morphogenesis [GO:0035115]; neural tube development [GO:0021915]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell population maintenance [GO:0019827]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; embryonic forelimb morphogenesis [GO:0035115]; neural tube development [GO:0021915]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell population maintenance [GO:0019827]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NW61	reviewed	PKHJ1_HUMAN	Pleckstrin homology domain-containing family J member 1 (PH domain-containing family J member 1) (Guanine nucleotide-releasing protein x)	PLEKHJ1 GNRPX	Homo sapiens (Human)	149			endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]		cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]	
Q9NW82	reviewed	WDR70_HUMAN	WD repeat-containing protein 70	WDR70	Homo sapiens (Human)	654				nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	enzyme binding [GO:0019899]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; enzyme binding [GO:0019899]	
Q9NWL6	reviewed	ASND1_HUMAN	Asparagine synthetase domain-containing protein 1 (HCV NS3-transactivated protein 1)	ASNSD1 NS3TP1 Nbla00058	Homo sapiens (Human)	643			asparagine biosynthetic process [GO:0006529]; glutamine metabolic process [GO:0006541]		asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]	asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]; asparagine biosynthetic process [GO:0006529]; glutamine metabolic process [GO:0006541]	
Q9NWM3	reviewed	CUED1_HUMAN	CUE domain-containing protein 1	CUEDC1	Homo sapiens (Human)	386					ubiquitin binding [GO:0043130]	ubiquitin binding [GO:0043130]	
Q9NX05	reviewed	F120C_HUMAN	Constitutive coactivator of PPAR-gamma-like protein 2 (Protein FAM120C) (Tumor antigen BJ-HCC-21)	FAM120C CXorf17	Homo sapiens (Human)	1096				nucleus [GO:0005634]	RNA binding [GO:0003723]	nucleus [GO:0005634]; RNA binding [GO:0003723]	
Q9NX77	reviewed	ENK13_HUMAN	Endogenous retrovirus group K member 13-1 Env polyprotein (Envelope polyprotein) (HERV-K_16p13.3 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]	ERVK13-1	Homo sapiens (Human)	482	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity). {ECO:0000250}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.			plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]	SUBCELLULAR LOCATION: Virion {ECO:0000250}.; SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NXD2	reviewed	MTMRA_HUMAN	Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10)	MTMR10	Homo sapiens (Human)	777		MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.		cytoplasm [GO:0005737]; cytosol [GO:0005829]		cytoplasm [GO:0005737]; cytosol [GO:0005829]	
Q9NXH8	reviewed	TOR4A_HUMAN	Torsin-4A (Torsin family 4 member A)	TOR4A C9orf167	Homo sapiens (Human)	423				endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; platelet alpha granule lumen [GO:0031093]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; platelet alpha granule lumen [GO:0031093]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NXJ0	reviewed	M4A12_HUMAN	Membrane-spanning 4-domains subfamily A member 12	MS4A12	Homo sapiens (Human)	267	FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex.		cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NXN4	reviewed	GDAP2_HUMAN	Ganglioside-induced differentiation-associated protein 2	GDAP2	Homo sapiens (Human)	497			response to retinoic acid [GO:0032526]	lysosomal membrane [GO:0005765]		lysosomal membrane [GO:0005765]; response to retinoic acid [GO:0032526]	
Q9NXP7	reviewed	GIN1_HUMAN	Gypsy retrotransposon integrase-like protein 1 (GIN-1) (Ty3/Gypsy integrase 1) (Zinc finger H2C2 domain-containing protein)	GIN1 TGIN1 ZH2C2	Homo sapiens (Human)	522		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	DNA integration [GO:0015074]		nucleic acid binding [GO:0003676]	nucleic acid binding [GO:0003676]; DNA integration [GO:0015074]	
Q9NXT0	reviewed	ZN586_HUMAN	Zinc finger protein 586	ZNF586	Homo sapiens (Human)	402	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NXU5	reviewed	ARL15_HUMAN	ADP-ribosylation factor-like protein 15 (ADP-ribosylation factor-related protein 2) (ARF-related protein 2)	ARL15 ARFRP2	Homo sapiens (Human)	204				extracellular exosome [GO:0070062]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	extracellular exosome [GO:0070062]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	
Q9NXZ1	reviewed	SAGE1_HUMAN	Sarcoma antigen 1 (Cancer/testis antigen 14) (CT14)	SAGE1 SAGE	Homo sapiens (Human)	904			snRNA 3'-end processing [GO:0034472]	integrator complex [GO:0032039]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]		integrator complex [GO:0032039]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; snRNA 3'-end processing [GO:0034472]	
Q9NY87	reviewed	SPNXC_HUMAN	Sperm protein associated with the nucleus on the X chromosome C (Cancer/testis antigen 11.3) (CT11.3) (Cancer/testis-associated protein CTp11) (Nuclear-associated protein SPAN-Xc) (SPANX-C) (SPANX family member C)	SPANXC	Homo sapiens (Human)	97				cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10626816}. Nucleus {ECO:0000269|PubMed:10626816}. Note=Associated with nuclear craters.
Q9NYF3	reviewed	FA53C_HUMAN	Protein FAM53C	FAM53C C5orf6	Homo sapiens (Human)	392			protein import into nucleus [GO:0006606]	nucleus [GO:0005634]		nucleus [GO:0005634]; protein import into nucleus [GO:0006606]	
Q9NYJ1	reviewed	COA4_HUMAN	Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing protein 8) (E2-induced gene 2 protein)	COA4 CHCHD8 E2IG2	Homo sapiens (Human)	87	FUNCTION: Putative COX assembly factor. {ECO:0000250}.		mitochondrial cytochrome c oxidase assembly [GO:0033617]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]		mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; mitochondrial cytochrome c oxidase assembly [GO:0033617]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23676665}.
Q9NYS7	reviewed	WSB2_HUMAN	WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein)	WSB2	Homo sapiens (Human)	404	FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.		intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	cytosol [GO:0005829]		cytosol [GO:0005829]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]	
Q9NYT0	reviewed	PLEK2_HUMAN	Pleckstrin-2	PLEK2	Homo sapiens (Human)	353	FUNCTION: May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.		actin cytoskeleton organization [GO:0030036]; intracellular signal transduction [GO:0035556]; positive regulation of plasma membrane bounded cell projection assembly [GO:0120034]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]	phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; actin cytoskeleton organization [GO:0030036]; intracellular signal transduction [GO:0035556]; positive regulation of plasma membrane bounded cell projection assembly [GO:0120034]	SUBCELLULAR LOCATION: Cell projection, lamellipodium membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Q9NYT6	reviewed	ZN226_HUMAN	Zinc finger protein 226	ZNF226	Homo sapiens (Human)	803	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9NYW1	reviewed	TA2R9_HUMAN	Taste receptor type 2 member 9 (T2R9) (Taste receptor family B member 6) (TRB6)	TAS2R9	Homo sapiens (Human)	312	FUNCTION: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). {ECO:0000250}.	MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell.	detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]	plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Q9NZF1	reviewed	PLAC8_HUMAN	Placenta-specific gene 8 protein (Protein C15)	PLAC8 BM-004	Homo sapiens (Human)	115			brown fat cell differentiation [GO:0050873]; defense response to bacterium [GO:0042742]; negative regulation of apoptotic process [GO:0043066]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cold [GO:0009409]; transcription by RNA polymerase II [GO:0006366]	azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]	chromatin binding [GO:0003682]	azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; chromatin binding [GO:0003682]; brown fat cell differentiation [GO:0050873]; defense response to bacterium [GO:0042742]; negative regulation of apoptotic process [GO:0043066]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cold [GO:0009409]; transcription by RNA polymerase II [GO:0006366]	
Q9NZH4	reviewed	PTTG3_HUMAN	Putative pituitary tumor-transforming gene 3 protein (hPTTG3) (Securin-3) (rcPTTG1)	PTTG3P PTTG3	Homo sapiens (Human)	202			chromosome organization [GO:0051276]; homologous chromosome segregation [GO:0045143]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; SH3 domain binding [GO:0017124]; chromosome organization [GO:0051276]; homologous chromosome segregation [GO:0045143]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q9NZP0	reviewed	OR6C3_HUMAN	Olfactory receptor 6C3 (HSA8)	OR6C3	Homo sapiens (Human)	311	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9NZP2	reviewed	OR6C2_HUMAN	Olfactory receptor 6C2 (HSA3)	OR6C2	Homo sapiens (Human)	312	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9NZP5	reviewed	O5AC2_HUMAN	Olfactory receptor 5AC2 (HSA1)	OR5AC2	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9P016	reviewed	THYN1_HUMAN	Thymocyte nuclear protein 1 (Thymocyte protein Thy28)	THYN1 THY28 HSPC144 MDS012 My0054	Homo sapiens (Human)	225	FUNCTION: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000250}.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9P1A2	reviewed	PP4RL_HUMAN	Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like	PPP4R1L C20orf192 PRO1085	Homo sapiens (Human)	415	FUNCTION: May be a regulatory subunit of serine/threonine-protein phosphatase 4.						
Q9P1P4	reviewed	TAAR3_HUMAN	Putative trace amine-associated receptor 3 (TaR-3) (Trace amine receptor 3) (hTaar3) (G-protein coupled receptor 57)	TAAR3P GPR57 TAAR3	Homo sapiens (Human)	343			sensory perception of chemical stimulus [GO:0007606]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]; sensory perception of chemical stimulus [GO:0007606]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9P1Q5	reviewed	OR1A1_HUMAN	Olfactory receptor 1A1 (Olfactory receptor 17-7) (OR17-7) (Olfactory receptor OR17-11)	OR1A1	Homo sapiens (Human)	309	FUNCTION: Odorant receptor. {ECO:0000305}.		signal transduction [GO:0007165]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9P1Z9	reviewed	CC180_HUMAN	Coiled-coil domain-containing protein 180	CCDC180 C9orf174 KIAA1529	Homo sapiens (Human)	1701				extracellular exosome [GO:0070062]		extracellular exosome [GO:0070062]	
Q9P215	reviewed	POGK_HUMAN	Pogo transposable element with KRAB domain	POGK KIAA1513 LST003 SLTP003	Homo sapiens (Human)	609			regulation of DNA-templated transcription [GO:0006355]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9P227	reviewed	RHG23_HUMAN	Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)	ARHGAP23 KIAA1501	Homo sapiens (Human)	1491	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.		regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GTPase activator activity [GO:0005096]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	
Q9P255	reviewed	ZN492_HUMAN	Zinc finger protein 492 (Zinc finger protein 115)	ZNF492 KIAA1473 ZNF115	Homo sapiens (Human)	531	FUNCTION: May be involved in transcriptional regulation.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9P281	reviewed	BAHC1_HUMAN	BAH and coiled-coil domain-containing protein 1 (Bromo adjacent homology domain-containing protein 2) (BAH domain-containing protein 2)	BAHCC1 BAHD2 KIAA1447	Homo sapiens (Human)	2639					chromatin binding [GO:0003682]	chromatin binding [GO:0003682]	
Q9P2B7	reviewed	CFA97_HUMAN	Cilia- and flagella-associated protein 97	CFAP97 KIAA1430	Homo sapiens (Human)	532			spermatogenesis [GO:0007283]			spermatogenesis [GO:0007283]	
Q9P2C4	reviewed	TM181_HUMAN	Transmembrane protein 181	TMEM181 GPR178 KIAA1423	Homo sapiens (Human)	612	FUNCTION: Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication. {ECO:0000269|PubMed:19965467}.			membrane [GO:0016020]	toxic substance binding [GO:0015643]	membrane [GO:0016020]; toxic substance binding [GO:0015643]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9P2D6	reviewed	F135A_HUMAN	Protein FAM135A	FAM135A KIAA1411	Homo sapiens (Human)	1515			cellular lipid metabolic process [GO:0044255]			cellular lipid metabolic process [GO:0044255]	
Q9P2F5	reviewed	STOX2_HUMAN	Storkhead-box protein 2	STOX2 KIAA1392	Homo sapiens (Human)	926			embryo development ending in birth or egg hatching [GO:0009792]; maternal placenta development [GO:0001893]; regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; embryo development ending in birth or egg hatching [GO:0009792]; maternal placenta development [GO:0001893]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q9P2N5	reviewed	RBM27_HUMAN	RNA-binding protein 27 (RNA-binding motif protein 27)	RBM27 KIAA1311	Homo sapiens (Human)	1060			mRNA processing [GO:0006397]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus speckle. Note=Incorporated into the nuclear speckles and to speckles proximal to the nuclear periphery. Also localizes to punctate structures in the cytoplasm termed cytospeckles (By similarity). {ECO:0000250}.
Q9P2S6	reviewed	ANKY1_HUMAN	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc finger MYND domain-containing protein 13)	ANKMY1 TSAL1 ZMYND13	Homo sapiens (Human)	941					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q9UBI9	reviewed	HDC_HUMAN	Headcase protein homolog (hHDC)	HECA HDC	Homo sapiens (Human)	543	FUNCTION: May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. {ECO:0000303|PubMed:11696983}.		negative regulation of mitotic cell cycle [GO:0045930]; respiratory tube development [GO:0030323]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; negative regulation of mitotic cell cycle [GO:0045930]; respiratory tube development [GO:0030323]	
Q9UBK7	reviewed	RBL2A_HUMAN	Rab-like protein 2A	RABL2A	Homo sapiens (Human)	228	FUNCTION: Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail. {ECO:0000250|UniProtKB:E9Q9D5}.		intracellular protein transport [GO:0006886]	endomembrane system [GO:0012505]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endomembrane system [GO:0012505]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]	
Q9UC06	reviewed	ZNF70_HUMAN	Zinc finger protein 70 (Zinc finger protein N27C7-1)	ZNF70	Homo sapiens (Human)	446	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	cytoplasm [GO:0005737]; megasporocyte nucleus [GO:0043076]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytoplasm [GO:0005737]; megasporocyte nucleus [GO:0043076]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UD57	reviewed	NKX12_HUMAN	NK1 transcription factor-related protein 2 (Homeobox protein SAX-1) (NKX-1.1)	NKX1-2 C10orf121 NKX1.1	Homo sapiens (Human)	310	FUNCTION: May function in cell specification, particularly in the CNS. {ECO:0000250}.		cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q9UDX4	reviewed	S14L3_HUMAN	SEC14-like protein 3 (Tocopherol-associated protein 2)	SEC14L3 TAP2	Homo sapiens (Human)	400	FUNCTION: Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]	lipid binding [GO:0008289]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; lipid binding [GO:0008289]	
Q9UF47	reviewed	DNJ5B_HUMAN	DnaJ homolog subfamily C member 5B (Cysteine-string protein isoform beta) (CSP-beta)	DNAJC5B CSPBETA	Homo sapiens (Human)	199				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17034881}; Lipid-anchor {ECO:0000269|PubMed:17034881}. Note=May be associated with the trans-Golgi network. {ECO:0000269|PubMed:17034881}.
Q9UFN0	reviewed	NPS3A_HUMAN	Protein NipSnap homolog 3A (NipSnap3A) (Protein NipSnap homolog 4) (NipSnap4) (Target for Salmonella secreted protein C) (TassC)	NIPSNAP3A NIPSNAP4 HSPC299	Homo sapiens (Human)	247				cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]		cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12427096}. Note=May be part of some vesicular structure distinct from lysosomal vesicles.
Q9UG63	reviewed	ABCF2_HUMAN	ATP-binding cassette sub-family F member 2 (Iron-inhibited ABC transporter 2)	ABCF2 HUSSY-18	Homo sapiens (Human)	623				membrane [GO:0016020]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	membrane [GO:0016020]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	
Q9UGF5	reviewed	O14J1_HUMAN	Olfactory receptor 14J1 (Hs6M1-28) (Olfactory receptor 5U1) (Olfactory receptor OR6-25)	OR14J1 OR5U1	Homo sapiens (Human)	321	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9UGF6	reviewed	OR5V1_HUMAN	Olfactory receptor 5V1 (Hs6M1-21) (Olfactory receptor OR6-26)	OR5V1	Homo sapiens (Human)	321	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9UGF7	reviewed	O12D3_HUMAN	Olfactory receptor 12D3 (Hs6M1-27) (Olfactory receptor OR6-27)	OR12D3	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9UGV2	reviewed	NDRG3_HUMAN	Protein NDRG3 (N-myc downstream-regulated gene 3 protein)	NDRG3	Homo sapiens (Human)	375			cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]		cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]	
Q9UH36	reviewed	SRR1L_HUMAN	SRR1-like protein (SRR1 domain-containing protein)	SRRD SRR1L	Homo sapiens (Human)	339	FUNCTION: Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. {ECO:0000250|UniProtKB:Q8K2M3}.		heme biosynthetic process [GO:0006783]; microtubule-based process [GO:0007017]; regulation of circadian rhythm [GO:0042752]; regulation of heme biosynthetic process [GO:0070453]; rhythmic process [GO:0048511]	cytoplasm [GO:0005737]; nucleus [GO:0005634]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; heme biosynthetic process [GO:0006783]; microtubule-based process [GO:0007017]; regulation of circadian rhythm [GO:0042752]; regulation of heme biosynthetic process [GO:0070453]; rhythmic process [GO:0048511]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8K2M3}. Note=Also found in intracellular organelles. {ECO:0000250|UniProtKB:Q8K2M3}.
Q9UH90	reviewed	FBX40_HUMAN	F-box only protein 40 (Muscle disease-related protein)	FBXO40 FBX40 KIAA1195	Homo sapiens (Human)	709	FUNCTION: Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis. {ECO:0000250}.	MISCELLANEOUS: The expression decreases in the dystrophic muscle of Limb-girdle muscular dystrophy (LGMD) patient.	muscle cell differentiation [GO:0042692]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; muscle cell differentiation [GO:0042692]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9UI15	reviewed	TAGL3_HUMAN	Transgelin-3 (Neuronal protein 22) (NP22) (Neuronal protein NP25)	TAGLN3 NP25	Homo sapiens (Human)	199			actin filament organization [GO:0007015]; central nervous system development [GO:0007417]; negative regulation of transcription by RNA polymerase II [GO:0000122]	actin cytoskeleton [GO:0015629]; nucleus [GO:0005634]	actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; nucleus [GO:0005634]; actin filament binding [GO:0051015]; actin filament organization [GO:0007015]; central nervous system development [GO:0007417]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
Q9UIG5	reviewed	PS1C1_HUMAN	Psoriasis susceptibility 1 candidate gene 1 protein (Protein SEEK1)	PSORS1C1 C6orf16 SEEK1	Homo sapiens (Human)	152							
Q9UJ72	reviewed	ANX10_HUMAN	Annexin A10 (Annexin-10) (Annexin-14)	ANXA10 ANX14	Homo sapiens (Human)	324				cytoplasm [GO:0005737]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]	cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]	
Q9UJC5	reviewed	SH3L2_HUMAN	SH3 domain-binding glutamic acid-rich-like protein 2 (Fovea-associated SH3 domain-binding protein)	SH3BGRL2 FASH3	Homo sapiens (Human)	107				cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]	SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; SH3 domain binding [GO:0017124]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12095696}.
Q9UJH8	reviewed	METRN_HUMAN	Meteorin	METRN C16orf23 RJD6	Homo sapiens (Human)	293	FUNCTION: Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity). {ECO:0000250}.		axonogenesis [GO:0007409]; glial cell differentiation [GO:0010001]; positive regulation of axonogenesis [GO:0050772]; radial glial cell differentiation [GO:0060019]	extracellular space [GO:0005615]	hormone activity [GO:0005179]	extracellular space [GO:0005615]; hormone activity [GO:0005179]; axonogenesis [GO:0007409]; glial cell differentiation [GO:0010001]; positive regulation of axonogenesis [GO:0050772]; radial glial cell differentiation [GO:0060019]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q9UJJ7	reviewed	RUSD1_HUMAN	RNA pseudouridylate synthase domain-containing protein 1 (Ribosomal large subunit pseudouridine synthase C-like protein)	RPUSD1 C16orf40 RLUCL	Homo sapiens (Human)	312			enzyme-directed rRNA pseudouridine synthesis [GO:0000455]		pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]	pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]	
Q9UJN7	reviewed	ZN391_HUMAN	Zinc finger protein 391	ZNF391	Homo sapiens (Human)	358	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UJT0	reviewed	TBE_HUMAN	Tubulin epsilon chain (Epsilon-tubulin)	TUBE1 TUBE	Homo sapiens (Human)	475			centrosome cycle [GO:0007098]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; pericentriolar material [GO:0000242]	GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; microtubule [GO:0005874]; pericentriolar material [GO:0000242]; GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200]; centrosome cycle [GO:0007098]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10620804}. Note=Associated with pericentriolar material. {ECO:0000269|PubMed:10620804}.
Q9UK10	reviewed	ZN225_HUMAN	Zinc finger protein 225	ZNF225	Homo sapiens (Human)	706	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UK12	reviewed	ZN222_HUMAN	Zinc finger protein 222	ZNF222	Homo sapiens (Human)	451	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UK28	reviewed	TM59L_HUMAN	Transmembrane protein 59-like (Brain-specific membrane-anchored protein)	TMEM59L BSMAP C19orf4	Homo sapiens (Human)	342	FUNCTION: Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding. {ECO:0000269|PubMed:20427278}.		branching involved in ureteric bud morphogenesis [GO:0001658]	Golgi membrane [GO:0000139]; membrane [GO:0016020]		Golgi membrane [GO:0000139]; membrane [GO:0016020]; branching involved in ureteric bud morphogenesis [GO:0001658]	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:20427278}; Single-pass type I membrane protein {ECO:0000305|PubMed:20427278}.
Q9UKI3	reviewed	VPRE3_HUMAN	Pre-B lymphocyte protein 3 (N27C7-2) (Protein VPreB3)	VPREB3 UNQ355/PRO619	Homo sapiens (Human)	123	FUNCTION: Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.		immune response [GO:0006955]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]		endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immune response [GO:0006955]	
Q9UKQ9	reviewed	KLK9_HUMAN	Kallikrein-9 (EC 3.4.21.-) (Kallikrein-like protein 3) (KLK-L3)	KLK9	Homo sapiens (Human)	250			proteolysis [GO:0006508]	extracellular region [GO:0005576]; secretory granule [GO:0030141]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9UKR8	reviewed	TSN16_HUMAN	Tetraspanin-16 (Tspan-16) (Tetraspanin TM4-B) (Transmembrane 4 superfamily member 16)	TSPAN16 TM4SF16	Homo sapiens (Human)	245				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9UKY7	reviewed	CDV3_HUMAN	Protein CDV3 homolog	CDV3 H41	Homo sapiens (Human)	258				cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q9UL59	reviewed	ZN214_HUMAN	Zinc finger protein 214 (BWSCR2-associated zinc finger protein 1) (BAZ-1)	ZNF214 BAZ1	Homo sapiens (Human)	606	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9ULD9	reviewed	ZN608_HUMAN	Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36)	ZNF608 KIAA1281	Homo sapiens (Human)	1512	FUNCTION: Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	metal ion binding [GO:0046872]	nucleus [GO:0005634]; metal ion binding [GO:0046872]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q9ULL0	reviewed	K1210_HUMAN	Acrosomal protein KIAA1210	KIAA1210	Homo sapiens (Human)	1709				acrosomal vesicle [GO:0001669]		acrosomal vesicle [GO:0001669]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:E9Q0C6}. Note=Localizes to the sex body in spermatocyte, acrosome, and near the ectoplasmic specialization. {ECO:0000250|UniProtKB:E9Q0C6}.
Q9ULL1	reviewed	PKHG1_HUMAN	Pleckstrin homology domain-containing family G member 1	PLEKHG1 KIAA1209	Homo sapiens (Human)	1385			regulation of small GTPase mediated signal transduction [GO:0051056]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; regulation of small GTPase mediated signal transduction [GO:0051056]	
Q9ULM0	reviewed	PKHH1_HUMAN	Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1)	PLEKHH1 KIAA1200	Homo sapiens (Human)	1364				cytoskeleton [GO:0005856]		cytoskeleton [GO:0005856]	
Q9UMS5	reviewed	PHTF1_HUMAN	Protein PHTF1	PHTF1 PHTF	Homo sapiens (Human)	762				cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum membrane [GO:0005789]		cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum membrane [GO:0005789]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:F1M8G0}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:F1M8G0}; Multi-pass membrane protein {ECO:0000255}.
Q9UND3	reviewed	NPIA1_HUMAN	Nuclear pore complex-interacting protein family member A1 (Nuclear pore complex-interacting protein) (NPIP)	NPIPA1 NPIP	Homo sapiens (Human)	350			mRNA transport [GO:0051028]; protein transport [GO:0015031]	nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]		nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; mRNA transport [GO:0051028]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:11586358}. Nucleus membrane {ECO:0000269|PubMed:11586358}. Note=Colocalizes with nuclear pore complex protein NUP62.
Q9UNX3	reviewed	RL26L_HUMAN	Ribosomal protein uL24-like (60S ribosomal protein L26-like 1) (Large ribosomal subunit protein uL24-like 1)	RPL26L1 RPL26P1	Homo sapiens (Human)	145			cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]	cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]	
Q9UPC5	reviewed	GPR34_HUMAN	Probable G-protein coupled receptor 34	GPR34	Homo sapiens (Human)	381	FUNCTION: Orphan receptor.		G protein-coupled receptor signaling pathway [GO:0007186]	plasma membrane [GO:0005886]	G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q9UPR6	reviewed	ZFR2_HUMAN	Zinc finger RNA-binding protein 2	ZFR2 KIAA1086	Homo sapiens (Human)	939					double-stranded RNA binding [GO:0003725]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	double-stranded RNA binding [GO:0003725]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	
Q9UQ74	reviewed	PSG8_HUMAN	Pregnancy-specific beta-1-glycoprotein 8 (PS-beta-G-8) (PSBG-8) (Pregnancy-specific glycoprotein 8)	PSG8	Homo sapiens (Human)	426			regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	protein tyrosine kinase binding [GO:1990782]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein tyrosine kinase binding [GO:1990782]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9XRX5	reviewed	HHLA3_HUMAN	Putative uncharacterized protein ANKRD13C-DT (ANKRD13C divergent transcript) (HERV-H LTR-associating protein 3) (Human endogenous retrovirus-H long terminal repeat-associating protein 3)	ANKRD13C-DT HHLA3	Homo sapiens (Human)	114							
Q9Y236	reviewed	OSGI2_HUMAN	Oxidative stress-induced growth inhibitor 2 (hT41)	OSGIN2 C8orf1	Homo sapiens (Human)	505	FUNCTION: May be involved in meiosis or the maturation of germ cells.		meiotic cell cycle [GO:0051321]; negative regulation of cell growth [GO:0030308]		growth factor activity [GO:0008083]	growth factor activity [GO:0008083]; meiotic cell cycle [GO:0051321]; negative regulation of cell growth [GO:0030308]	
Q9Y291	reviewed	RT33_HUMAN	Small ribosomal subunit protein mS33 (28S ribosomal protein S33, mitochondrial) (MRP-S33) (S33mt)	MRPS33 CGI-139 PTD003	Homo sapiens (Human)	106			mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279123}.
Q9Y2B9	reviewed	IPKG_HUMAN	cAMP-dependent protein kinase inhibitor gamma (PKI-gamma)	PKIG	Homo sapiens (Human)	76	FUNCTION: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. {ECO:0000250}.		negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by RNA polymerase II [GO:0000122]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	cAMP-dependent protein kinase inhibitor activity [GO:0004862]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
Q9Y2E4	reviewed	DIP2C_HUMAN	Disco-interacting protein 2 homolog C (DIP2 homolog C)	DIP2C KIAA0934	Homo sapiens (Human)	1556							
Q9Y2G7	reviewed	ZFP30_HUMAN	Zinc finger protein 30 homolog (Zfp-30) (Zinc finger protein 745)	ZFP30 KIAA0961 ZNF745	Homo sapiens (Human)	519	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y2H5	reviewed	PKHA6_HUMAN	Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)	PLEKHA6 KIAA0969 PEPP3	Homo sapiens (Human)	1048							
Q9Y2S6	reviewed	TMA7_HUMAN	Translation machinery-associated protein 7 (Coiled-coil domain-containing protein 72)	TMA7 CCDC72 HSPC016 HSPC330	Homo sapiens (Human)	64							
Q9Y312	reviewed	AAR2_HUMAN	Protein AAR2 homolog (AAR2 splicing factor homolog)	AAR2 C20orf4 CGI-23 PRO0225	Homo sapiens (Human)	384	FUNCTION: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. {ECO:0000250|UniProtKB:P32357}.		spliceosomal tri-snRNP complex assembly [GO:0000244]	spliceosomal complex [GO:0005681]; U5 snRNP [GO:0005682]		spliceosomal complex [GO:0005681]; U5 snRNP [GO:0005682]; spliceosomal tri-snRNP complex assembly [GO:0000244]	
Q9Y343	reviewed	SNX24_HUMAN	Sorting nexin-24	SNX24 SBBI31 UNQ654/PRO1284	Homo sapiens (Human)	169	FUNCTION: May be involved in several stages of intracellular trafficking. {ECO:0000250}.		protein transport [GO:0015031]	cytoplasmic vesicle membrane [GO:0030659]	phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]	cytoplasmic vesicle membrane [GO:0030659]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protein transport [GO:0015031]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Q9Y3B1	reviewed	PLD3B_HUMAN	PRELI domain containing protein 3B (Protein slowmo homolog 2)	PRELID3B C20orf45 SLMO2 CGI-107	Homo sapiens (Human)	194			phospholipid transport [GO:0015914]	mitochondrial intermembrane space [GO:0005758]	phosphatidic acid transfer activity [GO:1990050]	mitochondrial intermembrane space [GO:0005758]; phosphatidic acid transfer activity [GO:1990050]; phospholipid transport [GO:0015914]	
Q9Y3B9	reviewed	RRP15_HUMAN	RRP15-like protein (Ribosomal RNA-processing protein 15)	RRP15 KIAA0507 CGI-115	Homo sapiens (Human)	282			maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]	preribosome, large subunit precursor [GO:0030687]		preribosome, large subunit precursor [GO:0030687]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]	
Q9Y3D5	reviewed	RT18C_HUMAN	Small ribosomal subunit protein bS18m (28S ribosomal protein S18-1, mitochondrial) (MRP-S18-1) (28S ribosomal protein S18c, mitochondrial) (MRP-S18-c) (Mrps18-c) (S18mt-c) (Small ribosomal subunit protein bS18c)	MRPS18C CGI-134	Homo sapiens (Human)	142		MISCELLANEOUS: There are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c, this protein) binds to the same site as bacterial bS18, mS40 (bS18b) binds to a novel location of the 28S small subunit, and mL66 (bS18a) binds to the 39S large subunit. {ECO:0000305|PubMed:27023846}.	mitochondrial translation [GO:0032543]; translation [GO:0006412]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]	small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; translation [GO:0006412]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
Q9Y3N9	reviewed	OR2W1_HUMAN	Olfactory receptor 2W1 (Hs6M1-15) (Olfactory receptor OR6-13)	OR2W1	Homo sapiens (Human)	320	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9Y3P4	reviewed	RHBD3_HUMAN	Rhomboid domain-containing protein 3	RHBDD3 C22orf3	Homo sapiens (Human)	386			liver development [GO:0001889]; MAPK cascade [GO:0000165]; negative regulation of natural killer cell activation [GO:0032815]; positive regulation of protein catabolic process [GO:0045732]; regulation of acute inflammatory response [GO:0002673]; regulation of protein secretion [GO:0050708]; response to xenobiotic stimulus [GO:0009410]	membrane [GO:0016020]	serine-type endopeptidase activity [GO:0004252]	membrane [GO:0016020]; serine-type endopeptidase activity [GO:0004252]; liver development [GO:0001889]; MAPK cascade [GO:0000165]; negative regulation of natural killer cell activation [GO:0032815]; positive regulation of protein catabolic process [GO:0045732]; regulation of acute inflammatory response [GO:0002673]; regulation of protein secretion [GO:0050708]; response to xenobiotic stimulus [GO:0009410]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9Y3T6	reviewed	R3HC1_HUMAN	R3H and coiled-coil domain-containing protein 1	R3HCC1	Homo sapiens (Human)	440					nucleic acid binding [GO:0003676]	nucleic acid binding [GO:0003676]	
Q9Y426	reviewed	C2CD2_HUMAN	C2 domain-containing protein 2 (Transmembrane protein 24-like)	C2CD2 C21orf25 C21orf258 TMEM24L	Homo sapiens (Human)	696				cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]		cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9Y485	reviewed	DMXL1_HUMAN	DmX-like protein 1 (X-like 1 protein)	DMXL1 XL1	Homo sapiens (Human)	3027			vacuolar acidification [GO:0007035]	RAVE complex [GO:0043291]		RAVE complex [GO:0043291]; vacuolar acidification [GO:0007035]	
Q9Y4A0	reviewed	JERKL_HUMAN	Jerky protein homolog-like (Human homolog of mouse jerky gene protein) (HHMJG)	JRKL	Homo sapiens (Human)	524			central nervous system development [GO:0007417]	nucleus [GO:0005634]	DNA binding [GO:0003677]	nucleus [GO:0005634]; DNA binding [GO:0003677]; central nervous system development [GO:0007417]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000255|PROSITE-ProRule:PRU00583}.
Q9Y4A9	reviewed	O10H1_HUMAN	Olfactory receptor 10H1 (Olfactory receptor OR19-27)	OR10H1	Homo sapiens (Human)	318	FUNCTION: Odorant receptor. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9Y4E6	reviewed	WDR7_HUMAN	WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG)	WDR7 KIAA0541 TRAG	Homo sapiens (Human)	1490			hematopoietic progenitor cell differentiation [GO:0002244]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; hematopoietic progenitor cell differentiation [GO:0002244]	
Q9Y519	reviewed	T184B_HUMAN	Transmembrane protein 184B (Putative MAPK-activating protein FM08)	TMEM184B C22orf5 PSEC0108	Homo sapiens (Human)	407	FUNCTION: May activate the MAP kinase signaling pathway. {ECO:0000269|PubMed:12761501}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9Y534	reviewed	CSDC2_HUMAN	Cold shock domain-containing protein C2 (RNA-binding protein PIPPin)	CSDC2 PIPPIN	Homo sapiens (Human)	153	FUNCTION: RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). {ECO:0000250}.		mRNA processing [GO:0006397]; regulation of mRNA stability [GO:0043488]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; regulation of mRNA stability [GO:0043488]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=PIPPin-RNA complexes are located to the nucleus. {ECO:0000250}.
Q9Y536	reviewed	PAL4A_HUMAN	Peptidyl-prolyl cis-trans isomerase A-like 4A (PPIase A-like 4A) (EC 5.2.1.8) (Chromosome one-amplified sequence 2) (COAS-2) (Cyclophilin homolog overexpressed in liver cancer)	PPIAL4A COAS2 PPIAL4B	Homo sapiens (Human)	164	FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.	MISCELLANEOUS: It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1. {ECO:0000305}.	protein folding [GO:0006457]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62937}.
Q9Y581	reviewed	INSL6_HUMAN	Insulin-like peptide INSL6 (Insulin-like peptide 6) (Relaxin/insulin-like factor 1) [Cleaved into: Insulin-like peptide INSL6 B chain; Insulin-like peptide INSL6 A chain]	INSL6 RIF1	Homo sapiens (Human)	213	FUNCTION: May have a role in sperm development and fertilization.			extracellular region [GO:0005576]	hormone activity [GO:0005179]	extracellular region [GO:0005576]; hormone activity [GO:0005179]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q9Y5P0	reviewed	O51B4_HUMAN	Olfactory receptor 51B4 (Odorant receptor HOR5'beta1)	OR51B4	Homo sapiens (Human)	310	FUNCTION: Odorant receptor. {ECO:0000305}.		sensory perception of smell [GO:0007608]	membrane [GO:0016020]; plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; sensory perception of smell [GO:0007608]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q9Y5P2	reviewed	CSAG2_HUMAN	Chondrosarcoma-associated gene 2/3 protein (Cancer/testis antigen 24.2) (CT24.2) (Taxol-resistant-associated gene 3 protein) (TRAG-3)	CSAG2 TRAG3; CSAG3 CSAG3A	Homo sapiens (Human)	127	FUNCTION: Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype.		response to xenobiotic stimulus [GO:0009410]			response to xenobiotic stimulus [GO:0009410]	
Q9Y614	reviewed	ACL7B_HUMAN	Actin-like protein 7B (Actin-like-7-beta)	ACTL7B	Homo sapiens (Human)	415				actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; structural constituent of cytoskeleton [GO:0005200]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q9Y651	reviewed	SOX21_HUMAN	Transcription factor SOX-21 (SOX-A)	SOX21 SOX25 SOXA	Homo sapiens (Human)	276	FUNCTION: May play a role as an activator of transcription of OPRM1. Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells. May play a role in ameloblast differentiation. {ECO:0000250|UniProtKB:Q811W0}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; hair follicle development [GO:0001942]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; hair follicle development [GO:0001942]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Q9Y693	reviewed	LHPL6_HUMAN	LHFPL tetraspan subfamily member 6 protein (Lipoma HMGIC fusion partner)	LHFPL6 LHFP	Homo sapiens (Human)	200				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9Y6F7	reviewed	CDY2_HUMAN	Testis-specific chromodomain protein Y 2 (EC 2.3.1.48)	CDY2A CDY2; CDY2B	Homo sapiens (Human)	541	FUNCTION: May have histone acetyltransferase activity. {ECO:0000250}.		spermatogenesis [GO:0007283]	nucleus [GO:0005634]	histone acetyltransferase activity [GO:0004402]; transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]; histone acetyltransferase activity [GO:0004402]; transcription corepressor activity [GO:0003714]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q9Y6R6	reviewed	Z780B_HUMAN	Zinc finger protein 780B (Zinc finger protein 779)	ZNF780B ZNF779	Homo sapiens (Human)	833	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9Y6U7	reviewed	RN215_HUMAN	RING finger protein 215	RNF215	Homo sapiens (Human)	377			ubiquitin-dependent protein catabolic process [GO:0006511]	cytoplasm [GO:0005737]; membrane [GO:0016020]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-dependent protein catabolic process [GO:0006511]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9Y6X4	reviewed	F169A_HUMAN	Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A)	FAM169A KIAA0888	Homo sapiens (Human)	670				nuclear inner membrane [GO:0005637]		nuclear inner membrane [GO:0005637]	SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:22412018}. Nucleus inner membrane {ECO:0000269|PubMed:22412018}; Peripheral membrane protein {ECO:0000269|PubMed:22412018}; Nucleoplasmic side {ECO:0000269|PubMed:22412018}. Note=Enriched at the nuclear lamina.
Q9Y6Z4	reviewed	KIAS1_HUMAN	Putative uncharacterized protein KIF25-AS1 (KIF25 antisense RNA 1) (KIF25 antisense gene protein 1) (Protein HGC6.1)	KIF25-AS1 C6orf54 NCRNA00300	Homo sapiens (Human)	181							
A0A075B6S0	reviewed	TRGJ1_HUMAN	T cell receptor gamma joining 1	TRGJ1 TCRGJ1	Homo sapiens (Human)	16	FUNCTION: J region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0A075B6Y3	reviewed	TJA3_HUMAN	T cell receptor alpha joining 3	TRAJ3	Homo sapiens (Human)	20	FUNCTION: J region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B6Y9	reviewed	TJA42_HUMAN	T cell receptor alpha joining 42	TRAJ42	Homo sapiens (Human)	20	FUNCTION: J region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B700	reviewed	TJA31_HUMAN	T cell receptor alpha joining 31	TRAJ31	Homo sapiens (Human)	18	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A075B706	reviewed	TRDJ1_HUMAN	T cell receptor delta joining 1	TRDJ1	Homo sapiens (Human)	16	FUNCTION: J region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0A075B734	reviewed	AQP7B_HUMAN	Aquaporin-7B	AQP7B	Homo sapiens (Human)	347			glycerol transmembrane transport [GO:0015793]; water transport [GO:0006833]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	glycerol channel activity [GO:0015254]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; glycerol channel activity [GO:0015254]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250]; glycerol transmembrane transport [GO:0015793]; water transport [GO:0006833]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A0A075B759	reviewed	PAL4E_HUMAN	Peptidyl-prolyl cis-trans isomerase A-like 4E (PPIase A-like 4E) (EC 5.2.1.8)	PPIAL4E	Homo sapiens (Human)	164	FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.	MISCELLANEOUS: It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1. {ECO:0000305}.	protein folding [GO:0006457]	cytoplasm [GO:0005737]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62937}.
A0A087WTH1	reviewed	TM265_HUMAN	Transmembrane protein 265	TMEM265	Homo sapiens (Human)	108				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A0A087WUL8	reviewed	NBPFJ_HUMAN	Neuroblastoma breakpoint family member 19	NBPF19	Homo sapiens (Human)	3843		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1. {ECO:0000305}.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
A0A087WUV0	reviewed	ZN892_HUMAN	Zinc finger protein 892	ZNF892	Homo sapiens (Human)	522	FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A0A087WWA1	reviewed	P3URF_HUMAN	PIK3R3 upstream open reading frame protein	P3R3URF	Homo sapiens (Human)	95			phosphatidylinositol phosphate biosynthetic process [GO:0046854]	phosphatidylinositol 3-kinase complex [GO:0005942]	1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]	phosphatidylinositol 3-kinase complex [GO:0005942]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]	
A0A087WXS9	reviewed	TBC3I_HUMAN	TBC1 domain family member 3I	TBC1D3I	Homo sapiens (Human)	549	FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250|UniProtKB:Q8IZP1}.	MISCELLANEOUS: TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor. {ECO:0000305}.		plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IZP1}; Lipid-anchor {ECO:0000250|UniProtKB:Q8IZP1}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:Q8IZP1}.
A0A087X1G2	reviewed	TBC3K_HUMAN	TBC1 domain family member 3K	TBC1D3K	Homo sapiens (Human)	549	FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250|UniProtKB:Q8IZP1}.	MISCELLANEOUS: TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor. {ECO:0000305}.		plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IZP1}; Lipid-anchor {ECO:0000250|UniProtKB:Q8IZP1}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:Q8IZP1}.
A0A096LNP1	reviewed	D131B_HUMAN	Beta-defensin 131B (Defensin, beta 131)	DEFB131B	Homo sapiens (Human)	70	FUNCTION: Has antibacterial activity. {ECO:0000305}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A0A096LNW5	reviewed	NT2NR_HUMAN	Notch homolog 2 N-terminal-like protein R (NOTCH2NL-related)	NOTCH2NLR	Homo sapiens (Human)	274					calcium ion binding [GO:0005509]	calcium ion binding [GO:0005509]	
A0A096LP49	reviewed	CC187_HUMAN	Coiled-coil domain-containing protein 187	CCDC187	Homo sapiens (Human)	1063			microtubule anchoring [GO:0034453]	centrosome [GO:0005813]	microtubule binding [GO:0008017]	centrosome [GO:0005813]; microtubule binding [GO:0008017]; microtubule anchoring [GO:0034453]	
A0A096LPK9	reviewed	ORN4C_HUMAN	Olfactory receptor 4N4C	OR4N4C	Homo sapiens (Human)	316	FUNCTION: Odorant receptor. {ECO:0000305}.			membrane [GO:0016020]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A0A0A0MT70	reviewed	TJB26_HUMAN	T cell receptor beta joining 2-6	TRBJ2-6	Homo sapiens (Human)	17	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A0MT76	reviewed	LJ01_HUMAN	Immunoglobulin lambda joining 1	IGLJ1	Homo sapiens (Human)	42	FUNCTION: J region of the variable domain of immunoglobulin lambda light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0A0MT78	reviewed	TJB27_HUMAN	T cell receptor beta joining 2-7	TRBJ2-7	Homo sapiens (Human)	15	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A0MT87	reviewed	TJB24_HUMAN	T cell receptor beta joining 2-4	TRBJ2-4	Homo sapiens (Human)	16	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A0MT89	reviewed	KJ01_HUMAN	Immunoglobulin kappa joining 1	IGKJ1	Homo sapiens (Human)	12	FUNCTION: J region of the variable domain of immunoglobulin kappa light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0A0MT94	reviewed	TJB22_HUMAN	T cell receptor beta joining 2-2	TRBJ2-2	Homo sapiens (Human)	16	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A0MTA4	reviewed	TJB25_HUMAN	T cell receptor beta joining 2-5	TRBJ2-5	Homo sapiens (Human)	15	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0A0MTA7	reviewed	TJB21_HUMAN	T cell receptor beta joining 2-1	TRBJ2-1	Homo sapiens (Human)	16	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J200	reviewed	TJB23_HUMAN	T cell receptor beta joining 2-3	TRBJ2-3 hCG_2039521	Homo sapiens (Human)	16	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0B4J2A2	reviewed	PAL4C_HUMAN	Peptidyl-prolyl cis-trans isomerase A-like 4C (PPIase A-like 4C) (EC 5.2.1.8)	PPIAL4C	Homo sapiens (Human)	164	FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.	MISCELLANEOUS: It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1. {ECO:0000305}.	protein folding [GO:0006457]	cytoplasm [GO:0005737]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62937}.
A0A0C4DH62	reviewed	HJ01_HUMAN	Immunoglobulin heavy joining 1	IGHJ1	Homo sapiens (Human)	17	FUNCTION: J region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
A0A0D9SF12	reviewed	CC163_HUMAN	Transmembrane protein CCDC163 (Coiled-coil domain-containing protein 163) (coiled-coil domain containing 163 pseudogene)	CCDC163 C1orf231 CCDC163P	Homo sapiens (Human)	145				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A0G2JMD5	reviewed	PRA33_HUMAN	PRAME family member 33	PRAMEF33	Homo sapiens (Human)	474			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
A0A0J9YWL9	reviewed	TX13C_HUMAN	Putative testis-expressed protein 13C	TEX13C	Homo sapiens (Human)	993					metal ion binding [GO:0046872]; mRNA binding [GO:0003729]	metal ion binding [GO:0046872]; mRNA binding [GO:0003729]	
A0A0J9YWP8	reviewed	TJB13_HUMAN	T cell receptor beta joining 1-3	TRBJ1-3	Homo sapiens (Human)	16	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0J9YWX3	reviewed	TJB16_HUMAN	T cell receptor beta joining 1-6	TRBJ1-6	Homo sapiens (Human)	17	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0J9YX06	reviewed	TJB12_HUMAN	T cell receptor beta joining 1-2	TRBJ1-2	Homo sapiens (Human)	15	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0J9YX57	reviewed	MAB6B_HUMAN	Melanoma-associated antigen B6B	MAGEB6B	Homo sapiens (Human)	407			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
A0A0J9YXA8	reviewed	TJB11_HUMAN	T cell receptor beta joining 1-1	TRBJ1-1	Homo sapiens (Human)	15	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0J9YXG5	reviewed	TJB14_HUMAN	T cell receptor beta joining 1-4	TRBJ1-4	Homo sapiens (Human)	16	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0J9YXM7	reviewed	TJB15_HUMAN	T cell receptor beta joining 1-5	TRBJ1-5	Homo sapiens (Human)	16	FUNCTION: J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
A0A0J9YY54	reviewed	TX13D_HUMAN	Testis-expressed protein 13D	TEX13D	Homo sapiens (Human)	714					metal ion binding [GO:0046872]; mRNA binding [GO:0003729]	metal ion binding [GO:0046872]; mRNA binding [GO:0003729]	
A0A0U1RQE8	reviewed	GLYLB_HUMAN	Putative glycine N-acyltransferase-like protein 1B (EC 2.3.1.68)	GLYATL1B	Homo sapiens (Human)	302	FUNCTION: Putative acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor. {ECO:0000250|UniProtKB:Q969I3}.		glutamine metabolic process [GO:0006541]	mitochondrion [GO:0005739]	glutamine N-acyltransferase activity [GO:0047946]; glycine N-acyltransferase activity [GO:0047961]	mitochondrion [GO:0005739]; glutamine N-acyltransferase activity [GO:0047946]; glycine N-acyltransferase activity [GO:0047961]; glutamine metabolic process [GO:0006541]	
A0A0U1RQI7	reviewed	KLF18_HUMAN	Kruppel-like factor 18	KLF18	Homo sapiens (Human)	1052			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A0A0U1RR11	reviewed	CENL1_HUMAN	Centromere protein V-like protein 1 (Centromere protein V pseudogene 1)	CENPVL1 CENPVP1	Homo sapiens (Human)	272					carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872]	carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872]	
A0A0U1RRA0	reviewed	ZNOS_HUMAN	Putative transmembrane protein ZNF593OS (ZNF593 opposite strand protein)	ZNF593OS	Homo sapiens (Human)	63				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A0U1RRI6	reviewed	CENL3_HUMAN	Centromere protein V-like protein 3 (Centromere protein V pseudogene 3)	CENPVL3 CENPVP3	Homo sapiens (Human)	272					carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872]	carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872]	
A0A0U1RRL7	reviewed	MMPOS_HUMAN	Protein MMP24OS (MMP24 opposite strand)	MMP24OS MMP24-AS1	Homo sapiens (Human)	71							
A0A0X1KG70	reviewed	ORM2B_HUMAN	Olfactory receptor 4M2	OR4M2B	Homo sapiens (Human)	313	FUNCTION: Odorant receptor. {ECO:0000305}.			membrane [GO:0016020]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	membrane [GO:0016020]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A0A183	reviewed	LCE6A_HUMAN	Late cornified envelope protein 6A	LCE6A C1orf44	Homo sapiens (Human)	80	FUNCTION: Precursors of the cornified envelope of the stratum corneum. {ECO:0000250}.	MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.	keratinization [GO:0031424]			keratinization [GO:0031424]	
A0A1B0GTD5	reviewed	SMI11_HUMAN	Sperm microtubule inner protein 11 (Testis-expressed protein 49)	SPMIP11 TEX49	Homo sapiens (Human)	131	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella. {ECO:0000250|UniProtKB:A0A3Q1MT14}.			cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A0A3Q1MT14}. Note=Localizes to the A-tubules of DMTs. {ECO:0000250|UniProtKB:A0A3Q1MT14}.
A0A1B0GTH6	reviewed	CS2IP_HUMAN	Casein kinase II subunit alpha'-interacting protein	CSNKA2IP	Homo sapiens (Human)	734	FUNCTION: May play a role in chromatin regulation of male germ cells. {ECO:0000250|UniProtKB:Q8CH19}.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8CH19}. Note=Present in nuclei of spermatids during chromatin condensation. {ECO:0000250|UniProtKB:Q8CH19}.
A0A1B0GTH9	reviewed	ZN475_HUMAN	Zinc finger protein 475	ZNF475	Homo sapiens (Human)	108					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
A0A1B0GTI8	reviewed	TM272_HUMAN	Transmembrane protein 272	TMEM272	Homo sapiens (Human)	187				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A0A1B0GTL2	reviewed	CT204_HUMAN	Uncharacterized protein C20orf204	C20orf204 PRR17	Homo sapiens (Human)	189							
A0A1B0GTR0	reviewed	EDD13_HUMAN	Epididymal protein 13	EDDM13	Homo sapiens (Human)	161				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A0A1B0GTS1	reviewed	HSFX4_HUMAN	Heat shock transcription factor, X-linked member 4	HSFX4	Homo sapiens (Human)	333			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A0A1B0GTU1	reviewed	ZC11B_HUMAN	Zinc finger CCCH domain-containing protein 11B	ZC3H11B ZC3HDC11B	Homo sapiens (Human)	805	FUNCTION: May play a role in mRNA transport. {ECO:0000305}.		poly(A)+ mRNA export from nucleus [GO:0016973]		metal ion binding [GO:0046872]	metal ion binding [GO:0046872]; poly(A)+ mRNA export from nucleus [GO:0016973]	
A0A1B0GTY4	reviewed	TEX50_HUMAN	Testis-expressed protein 50	TEX50	Homo sapiens (Human)	177				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
A0A1B0GTZ2	reviewed	CC196_HUMAN	Putative coiled-coil domain-containing protein 196 (Long intergenic non-protein coding RNA 238)	CCDC196 C14orf53 LINC00238 NCRNA00238	Homo sapiens (Human)	297							
A0A1B0GUA7	reviewed	TEX51_HUMAN	Testis-expressed protein 51	TEX51	Homo sapiens (Human)	166				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
A0A1B0GUI7	reviewed	BRDOS_HUMAN	Putative uncharacterized protein BRD3OS (BRD3 opposite strand protein) (Long intergenic non-protein coding RNA 94) (Non-protein coding RNA 94)	BRD3OS LINC00094 NCRNA00094	Homo sapiens (Human)	84							
A0A1B0GUV7	reviewed	TEX48_HUMAN	Testis-expressed protein 48	TEX48	Homo sapiens (Human)	120							
A0A1B0GUW6	reviewed	SPEM3_HUMAN	Uncharacterized protein SPEM3	SPEM3	Homo sapiens (Human)	1196			flagellated sperm motility [GO:0030317]; sperm individualization [GO:0007291]	cytoplasm [GO:0005737]; membrane [GO:0016020]		cytoplasm [GO:0005737]; membrane [GO:0016020]; flagellated sperm motility [GO:0030317]; sperm individualization [GO:0007291]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GUW7	reviewed	SIM27_HUMAN	Small integral membrane protein 27 (TOPORS antisense RNA 1)	SMIM27 C9orf133 TOPORS-AS1	Homo sapiens (Human)	55				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GUX0	reviewed	SMIP1_HUMAN	Protein SPMIP1 (ATP6V1F neighbor gene protein) (Protein ATP6V1FNB) (Sperm-associated microtubule inner protein 1)	SPMIP1 ATP6V1FNB	Homo sapiens (Human)	176							
A0A1B0GUY1	reviewed	MRCOL_HUMAN	MARCO-like protein	MARCOL	Homo sapiens (Human)	285			extracellular matrix organization [GO:0030198]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; extracellular matrix organization [GO:0030198]	
A0A1B0GV03	reviewed	GG6L7_HUMAN	Golgin subfamily A member 6-like protein 7	GOLGA6L7	Homo sapiens (Human)	622				cis-Golgi network [GO:0005801]		cis-Golgi network [GO:0005801]	
A0A1B0GV85	reviewed	RELD1_HUMAN	Reelin domain-containing protein 1	REELD1	Homo sapiens (Human)	526				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GVH4	reviewed	PRS51_HUMAN	Serine protease-like protein 51	PRSS51	Homo sapiens (Human)	220			proteolysis [GO:0006508]	extracellular region [GO:0005576]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A0A1B0GVK7	reviewed	F240A_HUMAN	Protein FAM240A	FAM240A	Homo sapiens (Human)	83							
A0A1B0GVM6	reviewed	CK097_HUMAN	Uncharacterized protein C11orf97	C11orf97	Homo sapiens (Human)	126				ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]		ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9DAE7}.
A0A1B0GVN3	reviewed	CB092_HUMAN	Uncharacterized protein C2orf92 (Long intergenic non-protein coding RNA 1125)	C2orf92 LINC01125	Homo sapiens (Human)	265				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GVS7	reviewed	MDFI2_HUMAN	MyoD family inhibitor domain-containing protein 2	MDFIC2	Homo sapiens (Human)	189							
A0A1B0GVV1	reviewed	SIM35_HUMAN	Small integral membrane protein 35 (TMPRSS4 antisense RNA 1)	SMIM35 TMPRSS4-AS1	Homo sapiens (Human)	85				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GVX0	reviewed	LITAD_HUMAN	LITAF domain-containing protein (LITAF-like protein)	LITAFD	Homo sapiens (Human)	72			regulation of cytokine production [GO:0001817]	cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; nucleus [GO:0005634]	zinc ion binding [GO:0008270]	cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; nucleus [GO:0005634]; zinc ion binding [GO:0008270]; regulation of cytokine production [GO:0001817]	SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU01181}; Peripheral membrane protein {ECO:0000255|PROSITE-ProRule:PRU01181}.
A0A1B0GVY4	reviewed	SIM31_HUMAN	Small integral membrane protein 31	SMIM31	Homo sapiens (Human)	71				axon [GO:0030424]; membrane [GO:0016020]		axon [GO:0030424]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GVZ6	reviewed	MB3LB_HUMAN	Methyl-CpG-binding domain protein 3-like 2B	MBD3L2B	Homo sapiens (Human)	204		MISCELLANEOUS: The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes. {ECO:0000305}.	DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	methyl-CpG binding [GO:0008327]	nucleus [GO:0005634]; methyl-CpG binding [GO:0008327]; DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
A0A1B0GW64	reviewed	SIM33_HUMAN	Small integral membrane protein 33	SMIM33	Homo sapiens (Human)	132				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GWB2	reviewed	PRT1B_HUMAN	Proline rich transmembrane protein 1B	PRRT1B IFITMD8	Homo sapiens (Human)	263				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A0A1B0GWG4	reviewed	SRTM2_HUMAN	Serine-rich and transmembrane domain-containing 2	SERTM2	Homo sapiens (Human)	90				intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]		intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GWH4	reviewed	HSFX3_HUMAN	Heat shock transcription factor, X-linked member 3	HSFX3	Homo sapiens (Human)	333			regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A0A1B0GWH6	reviewed	LSP1N_HUMAN	LASP1 neighbor protein (Long intergenic non-protein coding RNA 672)	LASP1NB LINC00672	Homo sapiens (Human)	25	FUNCTION: May play a key role in the skin fibroblasts (FBs)-keratinocyte-like cells (KLCs). {ECO:0000269|PubMed:31410210}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GWK0	reviewed	PVLEF_HUMAN	Parvalbumin-like EF-hand-containing protein	PVALEF	Homo sapiens (Human)	134			skeletal muscle contraction [GO:0003009]	troponin complex [GO:0005861]	calcium ion binding [GO:0005509]	troponin complex [GO:0005861]; calcium ion binding [GO:0005509]; skeletal muscle contraction [GO:0003009]	
A0A1W2PP81	reviewed	TFKL5_HUMAN	TATA-box-binding protein-associated factor 11-like protein 5	TAF11L5	Homo sapiens (Human)	198			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
A0A1W2PPE2	reviewed	TFKL4_HUMAN	TATA-box-binding protein-associated factor 11-like protein 4	TAF11L4	Homo sapiens (Human)	198			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
A0A1W2PPF3	reviewed	DUXB_HUMAN	Double homeobox protein B	DUXB	Homo sapiens (Human)	345			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A0A1W2PPG7	reviewed	GBG14_HUMAN	Putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14	GNG14	Homo sapiens (Human)	69	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. {ECO:0000305}.		G protein-coupled receptor signaling pathway [GO:0007186]	heterotrimeric G-protein complex [GO:0005834]	G-protein beta-subunit binding [GO:0031681]	heterotrimeric G-protein complex [GO:0005834]; G-protein beta-subunit binding [GO:0031681]; G protein-coupled receptor signaling pathway [GO:0007186]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
A0A1W2PPH5	reviewed	TFLM_HUMAN	TATA-box-binding protein-associated factor 11-like protein 13	TAF11L13	Homo sapiens (Human)	198			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
A0A1W2PPK0	reviewed	CPHL2_HUMAN	Cytoplasmic polyadenylated homeobox-like protein 2	CPHXL2	Homo sapiens (Human)	400			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
A0A1W2PPL8	reviewed	TFKLN_HUMAN	TATA-box-binding protein-associated factor 11-like protein 14	TAF11L14	Homo sapiens (Human)	197			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
A0A1W2PPW3	reviewed	TFKLL_HUMAN	TATA-box-binding protein-associated factor 11-like protein 12	TAF11L12	Homo sapiens (Human)	197			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
A0A1W2PQ09	reviewed	TFKLK_HUMAN	TATA-box-binding protein-associated factor 11-like protein 11	TAF11L11	Homo sapiens (Human)	198			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
A0A1W2PQ27	reviewed	S72L1_HUMAN	RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 1 (RNA polymerase II subunit A C-terminal domain phosphatase SSU72L1) (CTD phosphatase SSU72L1) (EC 3.1.3.16)	SSU72L1	Homo sapiens (Human)	194	FUNCTION: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. {ECO:0000250|UniProtKB:Q9NP77}.		mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]	myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NP77}.
A0A1W2PQ64	reviewed	S72L5_HUMAN	RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 5 (RNA polymerase II subunit A C-terminal domain phosphatase SSU72L5) (CTD phosphatase SSU72L5) (EC 3.1.3.16)	SSU72L5	Homo sapiens (Human)	194	FUNCTION: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. {ECO:0000250|UniProtKB:Q9NP77}.		mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]	myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NP77}.
A0A1W2PQ73	reviewed	ERFL_HUMAN	ETS domain-containing transcription factor ERF-like (ETS repressor factor-like)	ERFL	Homo sapiens (Human)	354			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
A0A1W2PQC6	reviewed	S72L4_HUMAN	RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 4 (RNA polymerase II subunit A C-terminal domain phosphatase SSU72L4) (CTD phosphatase SSU72L4) (EC 3.1.3.16)	SSU72L4	Homo sapiens (Human)	194	FUNCTION: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. {ECO:0000250|UniProtKB:Q9NP77}.		mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]	myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NP77}.
A0A1W2PQJ5	reviewed	S72L3_HUMAN	RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 3 (RNA polymerase II subunit A C-terminal domain phosphatase SSU72L3) (CTD phosphatase SSU72L3) (EC 3.1.3.16)	SSU72L3	Homo sapiens (Human)	194	FUNCTION: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. {ECO:0000250|UniProtKB:Q9NP77}.		mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]	myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NP77}.
A0A1W2PQL4	reviewed	ZN722_HUMAN	Zinc finger protein 722	ZNF722 ZNF722P	Homo sapiens (Human)	384	FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A0A1W2PQU2	reviewed	KANTR_HUMAN	KANTR integral membrane protein	KANTR	Homo sapiens (Human)	76				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
A0A1W2PR48	reviewed	TLE7_HUMAN	Transducin-like enhancer protein 7	TLE7	Homo sapiens (Human)	441			negative regulation of canonical Wnt signaling pathway [GO:0090090]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription corepressor activity [GO:0003714]; negative regulation of canonical Wnt signaling pathway [GO:0090090]	
A0A1W2PR64	reviewed	TFKL9_HUMAN	TATA-box-binding protein-associated factor 11-like protein 9	TAF11L9	Homo sapiens (Human)	198			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
A0A1W2PR75	reviewed	S72L6_HUMAN	RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 6 (RNA polymerase II subunit A C-terminal domain phosphatase SSU72L6) (CTD phosphatase SSU72L6) (EC 3.1.3.16)	SSU72L6	Homo sapiens (Human)	194	FUNCTION: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. {ECO:0000250|UniProtKB:Q9NP77}.		mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]	myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NP77}.
A0A1W2PR95	reviewed	IGB1C_HUMAN	Immunoglobulin-binding protein 1 family member C	IGBP1C IGBP1P2	Homo sapiens (Human)	340			regulation of dephosphorylation [GO:0035303]; regulation of signal transduction [GO:0009966]	cytosol [GO:0005829]	protein phosphatase 2A binding [GO:0051721]	cytosol [GO:0005829]; protein phosphatase 2A binding [GO:0051721]; regulation of dephosphorylation [GO:0035303]; regulation of signal transduction [GO:0009966]	
A0A1W2PRP0	reviewed	FOXL3_HUMAN	Forkhead box protein L3	FOXL3	Homo sapiens (Human)	233	FUNCTION: Probable transcriptional regulator. {ECO:0000250|UniProtKB:Q12952}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
A0A1W2PRV1	reviewed	TFKL3_HUMAN	TATA-box-binding protein-associated factor 11-like protein 3	TAF11L3	Homo sapiens (Human)	198			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
A0A1W2PS18	reviewed	PMIS2_HUMAN	Transmembrane protein PMIS2	PMIS2	Homo sapiens (Human)	150	FUNCTION: May play a role in spermatozoa mobility. {ECO:0000250|UniProtKB:Q8CES1}.			intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]		intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A0A286YEV6	reviewed	SCGR4_HUMAN	Small cysteine and glycine repeat-containing protein 4 (Keratin-associated protein 28-4)	SCYGR4 KRTAP28-4	Homo sapiens (Human)	105	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.	MISCELLANEOUS: Human have a similar number of genes as other primates despite the relative hairlessness of humans. {ECO:0000303|PubMed:18721477}.		intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
A0A286YEX9	reviewed	SCGRX_HUMAN	Small cysteine and glycine repeat-containing protein 10 (Keratin-associated protein 28 family pseudogene 2)	SCYGR10 KRTAP28p2	Homo sapiens (Human)	47	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.	MISCELLANEOUS: Human have a similar number of genes as other primates despite the relative hairlessness of humans. {ECO:0000303|PubMed:18721477}.		intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
A0A286YEY9	reviewed	SCGR1_HUMAN	Small cysteine and glycine repeat-containing protein 1 (Keratin-associated protein 28-1)	SCYGR1 KRTAP28-1	Homo sapiens (Human)	88	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.	MISCELLANEOUS: Human have a similar number of genes as other primates despite the relative hairlessness of humans. {ECO:0000303|PubMed:18721477}.		intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
A0A286YF01	reviewed	SCGR7_HUMAN	Small cysteine and glycine repeat-containing protein 7 (Keratin-associated protein 28-7)	SCYGR7 KRTAP28-7	Homo sapiens (Human)	96	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.	MISCELLANEOUS: Human have a similar number of genes as other primates despite the relative hairlessness of humans. {ECO:0000303|PubMed:18721477}.		intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
A0A286YF18	reviewed	SMI44_HUMAN	Small integral membrane protein 44	SMIM44	Homo sapiens (Human)	149				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A286YF46	reviewed	SCGR5_HUMAN	Small cysteine and glycine repeat-containing protein 5 (Keratin-associated protein 28-5)	SCYGR5 KRTAP28-5	Homo sapiens (Human)	85	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.	MISCELLANEOUS: Human have a similar number of genes as other primates despite the relative hairlessness of humans. {ECO:0000303|PubMed:18721477}.		intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
A0A286YF58	reviewed	TM271_HUMAN	Transmembrane protein 271	TMEM271	Homo sapiens (Human)	385				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A0A286YF60	reviewed	SCGR3_HUMAN	Small cysteine and glycine repeat-containing protein 3 (Keratin-associated protein 28-3)	SCYGR3 KRTAP28-3	Homo sapiens (Human)	100	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.	MISCELLANEOUS: Human have a similar number of genes as other primates despite the relative hairlessness of humans. {ECO:0000303|PubMed:18721477}.		intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
A0A286YF77	reviewed	SCGR6_HUMAN	Small cysteine and glycine repeat-containing protein 6 (Keratin-associated protein 28-6)	SCYGR6 KRTAP28-6	Homo sapiens (Human)	105	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.	MISCELLANEOUS: Human have a similar number of genes as other primates despite the relative hairlessness of humans. {ECO:0000303|PubMed:18721477}.		intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
A0A286YFB4	reviewed	SCGR2_HUMAN	Small cysteine and glycine repeat-containing protein 2 (Keratin-associated protein 28-2)	SCYGR2 KRTAP28-2	Homo sapiens (Human)	120	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.	MISCELLANEOUS: Human have a similar number of genes as other primates despite the relative hairlessness of humans. {ECO:0000303|PubMed:18721477}.		intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
A0A286YFG1	reviewed	SCGR8_HUMAN	Small cysteine and glycine repeat-containing protein 8 (Keratin-associated protein 28-8)	SCYGR8 KRTAP28-8	Homo sapiens (Human)	108	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.	MISCELLANEOUS: Human have a similar number of genes as other primates despite the relative hairlessness of humans. {ECO:0000303|PubMed:18721477}.		intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
A0A2R8Y4L2	reviewed	RA1L3_HUMAN	Heterogeneous nuclear ribonucleoprotein A1-like 3 (Heterogeneous nuclear ribonucleoprotein A1 pseudogene 48)	HNRNPA1L3 HNRNPA1P48	Homo sapiens (Human)	275			mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]	mRNA 3'-UTR binding [GO:0003730]	catalytic step 2 spliceosome [GO:0071013]; mRNA 3'-UTR binding [GO:0003730]; mRNA splicing, via spliceosome [GO:0000398]	
A0A2R8Y4Y8	reviewed	OSP4B_HUMAN	Oocyte-secreted protein 4B	OOSP4B	Homo sapiens (Human)	160				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A0A2R8Y7D0	reviewed	TINCR_HUMAN	Ubiquitin domain-containing protein TINCR (Placenta-specific protein 2) (Terminal differentiation-induced cornification regulator)	TINCR LINC00036 NCRNA00036 PLAC2	Homo sapiens (Human)	120							
A0A2R8Y7Y5	reviewed	CIST1_HUMAN	Protein CIST1 (Colon intestine and stomach enriched-protein 1)	CIST1	Homo sapiens (Human)	234				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
A0A2R8YFL7	reviewed	OSP4A_HUMAN	Oocyte-secreted protein 4A	OOSP4A	Homo sapiens (Human)	184				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A0A2R8YFM6	reviewed	OOSP3_HUMAN	Oocyte-secreted protein 3	OOSP3	Homo sapiens (Human)	193				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A0A3B3IRV3	reviewed	MCTS2_HUMAN	Malignant T-cell-amplified sequence 2	MCTS2	Homo sapiens (Human)	181		MISCELLANEOUS: Imprinted gene expressed from the paternal allele in fetal spinal cord. {ECO:0000305|PubMed:17291163}.	formation of translation preinitiation complex [GO:0001731]	cytoplasm [GO:0005737]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; RNA binding [GO:0003723]; formation of translation preinitiation complex [GO:0001731]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ULC4}.
A0A3B3IU46	reviewed	RMACL_HUMAN	RNA guanine-N7 methyltransferase-activating subunit-like protein	RAMACL	Homo sapiens (Human)	118	FUNCTION: Component of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. {ECO:0000250|UniProtKB:Q9BTL3}.		methylation [GO:0032259]; recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [GO:0036031]; RNA 5'-cap (guanine-N7)-methylation [GO:0106005]	mRNA cap binding complex [GO:0005845]; mRNA cap methyltransferase complex [GO:0031533]	RNA binding [GO:0003723]	mRNA cap binding complex [GO:0005845]; mRNA cap methyltransferase complex [GO:0031533]; RNA binding [GO:0003723]; methylation [GO:0032259]; recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [GO:0036031]; RNA 5'-cap (guanine-N7)-methylation [GO:0106005]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BTL3}.
A0A3B3IU63	reviewed	H2AL3_HUMAN	Histone H2A-like 3 (H2A.L.3)	H2AL3 H2AL1RP	Homo sapiens (Human)	148	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000305}.			nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
A0A494BZU4	reviewed	T217B_HUMAN	Putative transmembrane protein 217B	TMEM217B	Homo sapiens (Human)	170				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A0A494C071	reviewed	PWWP4_HUMAN	PWWP domain-containing DNA repair factor 4	PWWP4	Homo sapiens (Human)	2061							
A0A494C086	reviewed	SPD21_HUMAN	Putative speedy protein E21	SPDYE21	Homo sapiens (Human)	402					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
A0A494C0Z2	reviewed	SPD13_HUMAN	Putative speedy protein E13	SPDYE13	Homo sapiens (Human)	265					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
A0A494C103	reviewed	SPADH_HUMAN	CUB domain-containing protein	SPADH	Homo sapiens (Human)	137							
A0A494C191	reviewed	SPD9_HUMAN	Putative speedy protein E9	SPDYE9	Homo sapiens (Human)	265					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
A0A5F9ZHS7	reviewed	NFILZ_HUMAN	NFIL3 like protein (NFIL3 like basic leucine zipper)	NFILZ	Homo sapiens (Human)	289			circadian rhythm [GO:0007623]; regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; circadian rhythm [GO:0007623]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
A0A6I8PU40	reviewed	TUG1_HUMAN	Taurine up-regulated 1 protein	TUG1	Homo sapiens (Human)	153				mitochondrial membrane [GO:0031966]; nuclear membrane [GO:0031965]		mitochondrial membrane [GO:0031966]; nuclear membrane [GO:0031965]	SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:32894169, ECO:0000305|PubMed:31155234}; Single-pass type I membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:32894169}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:32894169}.
A0PG75	reviewed	PLS5_HUMAN	Phospholipid scramblase family member 5	PLSCR5	Homo sapiens (Human)	271			plasma membrane phospholipid scrambling [GO:0017121]	plasma membrane [GO:0005886]	phospholipid scramblase activity [GO:0017128]	plasma membrane [GO:0005886]; phospholipid scramblase activity [GO:0017128]; plasma membrane phospholipid scrambling [GO:0017121]	
A0PJX2	reviewed	TLDC2_HUMAN	TLD domain-containing protein 2 (TBC/LysM-associated domain-containing protein 2)	TLDC2	Homo sapiens (Human)	215			response to oxidative stress [GO:0006979]	nucleus [GO:0005634]		nucleus [GO:0005634]; response to oxidative stress [GO:0006979]	
A0PJX8	reviewed	TMM82_HUMAN	Transmembrane protein 82	TMEM82	Homo sapiens (Human)	343				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A0PJZ0	reviewed	A20A5_HUMAN	Putative ankyrin repeat domain-containing protein 20A5 (Ankyrin repeat domain-containing protein 20A5 pseudogene)	ANKRD20A5P ANKRD20A5	Homo sapiens (Human)	165							
A1A4G5	reviewed	LNP1_HUMAN	Leukemia NUP98 fusion partner 1	LNP1 NP3	Homo sapiens (Human)	178							
A1IGU5	reviewed	ARH37_HUMAN	Rho guanine nucleotide exchange factor 37	ARHGEF37	Homo sapiens (Human)	675	FUNCTION: May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.			cytoplasm [GO:0005737]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor activity [GO:0005085]	
A1L157	reviewed	TSN11_HUMAN	Tetraspanin-11 (Tspan-11)	TSPAN11	Homo sapiens (Human)	253				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A1L162	reviewed	ERIC2_HUMAN	Glutamate-rich protein 2	ERICH2	Homo sapiens (Human)	156							
A1L170	reviewed	CA226_HUMAN	Uncharacterized protein C1orf226	C1orf226	Homo sapiens (Human)	272							
A1L429	reviewed	GG12C_HUMAN	G antigen 12B/C/D/E (GAGE-12B) (GAGE-12C) (GAGE-12D) (GAGE-12E)	GAGE12B; GAGE12C; GAGE12D; GAGE12E	Homo sapiens (Human)	117		MISCELLANEOUS: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
A1L443	reviewed	NTM2F_HUMAN	NUT family member 2F	NUTM2F FAM22F	Homo sapiens (Human)	756							
A2A2Z9	reviewed	AN18B_HUMAN	Ankyrin repeat domain-containing protein 18B	ANKRD18B	Homo sapiens (Human)	1011							
A2A368	reviewed	MAGBG_HUMAN	Melanoma-associated antigen B16 (MAGE-B16 antigen)	MAGEB16	Homo sapiens (Human)	324			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
A2A3L6	reviewed	TTC24_HUMAN	Tetratricopeptide repeat protein 24 (TPR repeat protein 24)	TTC24	Homo sapiens (Human)	582							
A2RU37	reviewed	CI170_HUMAN	Uncharacterized protein encoded by LINC02872 (Long intergenic non-protein coding RNA 2872)	LINC02872 C9orf170	Homo sapiens (Human)	121							
A2RU67	reviewed	F234B_HUMAN	Protein FAM234B	FAM234B KIAA1467	Homo sapiens (Human)	622				cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]		cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Golgi outpost {ECO:0000250|UniProtKB:D3ZWJ9}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:D3ZWJ9}. Note=Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. {ECO:0000250|UniProtKB:D3ZWJ9}.
A2RUQ5	reviewed	CQ102_HUMAN	Uncharacterized protein TMEM132E-DT (TMEM132E divergent transcript)	TMEM132E-DT C17orf102	Homo sapiens (Human)	167							
A2RUT3	reviewed	TMM89_HUMAN	Transmembrane protein 89	TMEM89	Homo sapiens (Human)	159				membrane [GO:0016020]; nucleus [GO:0005634]		membrane [GO:0016020]; nucleus [GO:0005634]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A3QJZ6	reviewed	PRA22_HUMAN	PRAME family member 22	PRAMEF22	Homo sapiens (Human)	481			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
A3QJZ7	reviewed	PRA27_HUMAN	PRAME family member 27	PRAMEF27	Homo sapiens (Human)	478			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
A4D0T7	reviewed	SIM30_HUMAN	Small integral membrane protein 30	SMIM30	Homo sapiens (Human)	59				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A4D1F6	reviewed	LRRD1_HUMAN	Leucine-rich repeat and death domain-containing protein 1	LRRD1	Homo sapiens (Human)	860			signal transduction [GO:0007165]			signal transduction [GO:0007165]	
A4D1Z8	reviewed	GRIFN_HUMAN	Grifin (Galectin-related inter-fiber protein)	GRIFIN	Homo sapiens (Human)	144					carbohydrate binding [GO:0030246]	carbohydrate binding [GO:0030246]	
A4D263	reviewed	SMIP7_HUMAN	Protein SPMIP7 (Sperm microtubule inner protein 7) (Spermatogenesis-associated protein 48)	SPMIP7 C7orf72 SPATA48	Homo sapiens (Human)	438	FUNCTION: Essential for normal spermatogenesis. {ECO:0000250|UniProtKB:Q5NC83}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]			cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	
A4FU28	reviewed	CTGE9_HUMAN	cTAGE family member 9 (Protein cTAGE-9)	CTAGE9	Homo sapiens (Human)	777			endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A4IF30	reviewed	S35F4_HUMAN	Solute carrier family 35 member F4	SLC35F4 C14orf36	Homo sapiens (Human)	521	FUNCTION: Putative solute transporter. {ECO:0000305}.			membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A4QPB2	reviewed	LRP5L_HUMAN	Low-density lipoprotein receptor-related protein 5-like protein (LRP-5-like)	LRP5L	Homo sapiens (Human)	252							
A5PLL1	reviewed	AN34B_HUMAN	Ankyrin repeat domain-containing protein 34B	ANKRD34B	Homo sapiens (Human)	514			piRNA processing [GO:0034587]	nucleus [GO:0005634]; pi-body [GO:0071546]		nucleus [GO:0005634]; pi-body [GO:0071546]; piRNA processing [GO:0034587]	SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
A5YM69	reviewed	ARG35_HUMAN	Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein)	ARHGEF35 ARHGEF5L	Homo sapiens (Human)	484							
A6NC05	reviewed	YD286_HUMAN	Glutaredoxin-like protein C5orf63	C5orf63	Homo sapiens (Human)	138							
A6NC57	reviewed	ANR62_HUMAN	Ankyrin repeat domain-containing protein 62	ANKRD62	Homo sapiens (Human)	917							
A6NC97	reviewed	F172B_HUMAN	Putative protein FAM172B (FAM172B pseudogene)	FAM172BP FAM172B	Homo sapiens (Human)	362			regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	membrane [GO:0016020]; nucleus [GO:0005634]		membrane [GO:0016020]; nucleus [GO:0005634]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A6NCF5	reviewed	KLH33_HUMAN	Kelch-like protein 33	KLHL33	Homo sapiens (Human)	533							
A6NCF6	reviewed	MA13P_HUMAN	Putative MAGE domain-containing protein MAGEA13P	MAGEA13P	Homo sapiens (Human)	341			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
A6NCI5	reviewed	SIM16_HUMAN	Putative transmembrane protein encoded by LINC00862 (Small integral membrane protein 16)	LINC00862 C1orf98 SMIM16	Homo sapiens (Human)	91				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A6NCI8	reviewed	CB078_HUMAN	Uncharacterized protein C2orf78	C2orf78	Homo sapiens (Human)	922							
A6NCJ1	reviewed	TKTI1_HUMAN	Tektin bundle-interacting protein 1	TEKTIP1 C19orf71	Homo sapiens (Human)	209	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Located at the center of the tektin bundle where may function to recruit tektins or stabilize the bundle. {ECO:0000250|UniProtKB:Q2M2T2}.			axonemal microtubule [GO:0005879]		axonemal microtubule [GO:0005879]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q2M2T2}.
A6NCL2	reviewed	LRCL1_HUMAN	Leucine-rich colipase-like protein 1	LRCOL1	Homo sapiens (Human)	159			digestion [GO:0007586]; lipid catabolic process [GO:0016042]	extracellular region [GO:0005576]	enzyme activator activity [GO:0008047]	extracellular region [GO:0005576]; enzyme activator activity [GO:0008047]; digestion [GO:0007586]; lipid catabolic process [GO:0016042]	
A6NCL7	reviewed	AN33B_HUMAN	Ankyrin repeat domain-containing protein 33B	ANKRD33B	Homo sapiens (Human)	494							
A6NCM1	reviewed	IQCAL_HUMAN	IQ and AAA domain-containing protein 1-like (IQ and AAA domain-containing protein 1 pseudogene 1)	IQCA1L IQCA1P1	Homo sapiens (Human)	818					ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568]	
A6NCQ9	reviewed	RN222_HUMAN	RING finger protein 222	RNF222	Homo sapiens (Human)	220				membrane [GO:0016020]	metal ion binding [GO:0046872]	membrane [GO:0016020]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A6ND91	reviewed	ASPDH_HUMAN	Aspartate dehydrogenase domain-containing protein	ASPDH	Homo sapiens (Human)	283			NAD biosynthetic process [GO:0009435]		aspartate dehydrogenase activity [GO:0033735]; NADP binding [GO:0050661]	aspartate dehydrogenase activity [GO:0033735]; NADP binding [GO:0050661]; NAD biosynthetic process [GO:0009435]	
A6NDE8	reviewed	GG12H_HUMAN	G antigen 12H (GAGE-12H)	GAGE12H	Homo sapiens (Human)	117		MISCELLANEOUS: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
A6NDK9	reviewed	GOG6C_HUMAN	Golgin subfamily A member 6C	GOLGA6C	Homo sapiens (Human)	693			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
A6NDL7	reviewed	MT21E_HUMAN	Putative methyltransferase-like protein 21E pseudogene (EC 2.1.1.-)	METTL21EP METTL21CP1	Homo sapiens (Human)	271	FUNCTION: Protein-lysine methyltransferase. {ECO:0000250}.		methylation [GO:0032259]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-lysine N-methyltransferase activity [GO:0016279]; methylation [GO:0032259]	
A6NDX4	reviewed	YO011_HUMAN	Putative transmembrane protein ENSP00000320207		Homo sapiens (Human)	124				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A6NDY2	reviewed	F90AA_HUMAN	Putative protein FAM90A10	FAM90A10 FAM90A10P	Homo sapiens (Human)	464							
A6NDZ8	reviewed	MB3L4_HUMAN	Putative methyl-CpG-binding domain protein 3-like 4 (MBD3-like protein 4)	MBD3L4	Homo sapiens (Human)	208		MISCELLANEOUS: The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.	DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	methyl-CpG binding [GO:0008327]	nucleus [GO:0005634]; methyl-CpG binding [GO:0008327]; DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
A6NE01	reviewed	F186A_HUMAN	Protein FAM186A	FAM186A	Homo sapiens (Human)	2351							
A6NE02	reviewed	BTBDH_HUMAN	BTB/POZ domain-containing protein 17 (Galectin-3-binding protein-like)	BTBD17	Homo sapiens (Human)	478			negative regulation of viral genome replication [GO:0045071]; response to virus [GO:0009615]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; negative regulation of viral genome replication [GO:0045071]; response to virus [GO:0009615]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A6NE82	reviewed	MB3L3_HUMAN	Putative methyl-CpG-binding domain protein 3-like 3 (MBD3-like protein 3)	MBD3L3	Homo sapiens (Human)	208		MISCELLANEOUS: The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.	DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	methyl-CpG binding [GO:0008327]	nucleus [GO:0005634]; methyl-CpG binding [GO:0008327]; DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
A6NEE1	reviewed	PLHD1_HUMAN	Pleckstrin homology domain-containing family D member 1 (PH domain-containing family D member 1)	PLEKHD1	Homo sapiens (Human)	506							
A6NEF3	reviewed	GG6L4_HUMAN	Golgin subfamily A member 6-like protein 4	GOLGA6L4	Homo sapiens (Human)	574							
A6NEH6	reviewed	TM247_HUMAN	Transmembrane protein 247	TMEM247	Homo sapiens (Human)	219				endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]		endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NEH8	reviewed	ZNAS2_HUMAN	Putative uncharacterized protein encoded by ZNF503-AS2 (ZNF503 antisense RNA 2)	ZNF503-AS2 C10orf41 NCRNA00245	Homo sapiens (Human)	195							
A6NEK1	reviewed	ARRD5_HUMAN	Arrestin domain-containing protein 5	ARRDC5	Homo sapiens (Human)	342			protein transport [GO:0015031]	cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886]		cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886]; protein transport [GO:0015031]	
A6NEL3	reviewed	F86C2_HUMAN	Putative protein FAM86C2P (EC 2.1.1.-)	FAM86C2P	Homo sapiens (Human)	165			methylation [GO:0032259]		methyltransferase activity [GO:0008168]	methyltransferase activity [GO:0008168]; methylation [GO:0032259]	
A6NEN9	reviewed	CX065_HUMAN	Uncharacterized protein CXorf65	CXorf65	Homo sapiens (Human)	183							
A6NEQ2	reviewed	F181B_HUMAN	Protein FAM181B	FAM181B	Homo sapiens (Human)	426							
A6NER3	reviewed	GG12J_HUMAN	G antigen 12J (GAGE-12J)	GAGE12J	Homo sapiens (Human)	117		MISCELLANEOUS: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
A6NEV1	reviewed	PR23A_HUMAN	Proline-rich protein 23A	PRR23A	Homo sapiens (Human)	266							
A6NEY8	reviewed	PRXD1_HUMAN	Putative prolyl-tRNA synthetase associated domain-containing protein 1 (PrdX deacylase domain-containing protein 1) (Prolyl-tRNA synthetase associated domain-containing protein 1 pseudogene)	PRORSD1P NCRNA00117 PRDXDD1P	Homo sapiens (Human)	169					aminoacyl-tRNA editing activity [GO:0002161]	aminoacyl-tRNA editing activity [GO:0002161]	
A6NF01	reviewed	P121B_HUMAN	Putative nuclear envelope pore membrane protein POM 121B	POM121B	Homo sapiens (Human)	834	FUNCTION: Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}.		mRNA transport [GO:0051028]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]	nuclear pore [GO:0005643]	nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]	nuclear pore [GO:0005643]; nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]; mRNA transport [GO:0051028]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250}.
A6NFA0	reviewed	S31F3_HUMAN	Protein SPATA31F3 (Protein FAM205C)	SPATA31F3 FAM205C FAM205CP	Homo sapiens (Human)	338				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A6NFE2	reviewed	SMCO2_HUMAN	Single-pass membrane and coiled-coil domain-containing protein 2	SMCO2 C12orf70	Homo sapiens (Human)	343				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A6NFF2	reviewed	NP1L6_HUMAN	Putative nucleosome assembly protein 1-like 6	NAP1L6P NAP1L6	Homo sapiens (Human)	107			nucleosome assembly [GO:0006334]	nucleus [GO:0005634]		nucleus [GO:0005634]; nucleosome assembly [GO:0006334]	
A6NFH5	reviewed	FBP12_HUMAN	Fatty acid-binding protein 12	FABP12	Homo sapiens (Human)	140	FUNCTION: May play a role in lipid transport. {ECO:0000250}.		fatty acid transport [GO:0015908]	cytosol [GO:0005829]; nucleus [GO:0005634]	fatty acid binding [GO:0005504]	cytosol [GO:0005829]; nucleus [GO:0005634]; fatty acid binding [GO:0005504]; fatty acid transport [GO:0015908]	
A6NFN9	reviewed	ANKUB_HUMAN	Protein ANKUB1 (Ankyrin repeat and ubiquitin domain-containing 1)	ANKUB1 C3orf16	Homo sapiens (Human)	502							
A6NFU0	reviewed	F187A_HUMAN	Ig-like V-type domain-containing protein FAM187A	FAM187A	Homo sapiens (Human)	413				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A6NFU8	reviewed	PGPIL_HUMAN	Pyroglutamyl-peptidase 1-like protein (EC 3.4.19.-)	PGPEP1L	Homo sapiens (Human)	196			proteolysis [GO:0006508]		cysteine-type peptidase activity [GO:0008234]	cysteine-type peptidase activity [GO:0008234]; proteolysis [GO:0006508]	
A6NFY4	reviewed	NEMP2_HUMAN	Nuclear envelope integral membrane protein 2	NEMP2 TMEM194B	Homo sapiens (Human)	417				nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]		nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]	SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:Q6ZQE4}; Multi-pass membrane protein {ECO:0000255}; Nucleoplasmic side {ECO:0000250|UniProtKB:B9X187}.
A6NFZ4	reviewed	FA24A_HUMAN	Protein FAM24A	FAM24A	Homo sapiens (Human)	105				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A6NGA9	reviewed	TM202_HUMAN	Transmembrane protein 202	TMEM202	Homo sapiens (Human)	273				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NGB0	reviewed	T191C_HUMAN	Transmembrane protein 191C	TMEM191C	Homo sapiens (Human)	347				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A6NGB7	reviewed	TM221_HUMAN	Transmembrane protein 221	TMEM221	Homo sapiens (Human)	291				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NGE4	reviewed	DC8L1_HUMAN	DDB1- and CUL4-associated factor 8-like protein 1 (WD repeat-containing protein 42B)	DCAF8L1 WDR42B	Homo sapiens (Human)	600				Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; nucleus [GO:0005634]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	
A6NGG3	reviewed	CI092_HUMAN	Putative uncharacterized protein encoded by LINC03041 (Long intergenic non-protein coding RNA 3041)	LINC03041 C9orf92	Homo sapiens (Human)	77							
A6NGH7	reviewed	CC160_HUMAN	Coiled-coil domain-containing protein 160	CCDC160	Homo sapiens (Human)	325							
A6NGH8	reviewed	ANR61_HUMAN	Ankyrin repeat domain-containing protein 61	ANKRD61	Homo sapiens (Human)	418				nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	
A6NGK3	reviewed	GAG10_HUMAN	G antigen 10 (GAGE-10)	GAGE10	Homo sapiens (Human)	116		MISCELLANEOUS: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
A6NGN4	reviewed	PRA25_HUMAN	PRAME family member 25	PRAMEF25	Homo sapiens (Human)	478			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
A6NGN9	reviewed	IGLO5_HUMAN	IgLON family member 5	IGLON5	Homo sapiens (Human)	336				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A6NGR9	reviewed	MROH6_HUMAN	Maestro heat-like repeat-containing protein family member 6	MROH6 C8orf73	Homo sapiens (Human)	719				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
A6NGS2	reviewed	ERIC4_HUMAN	Glutamate-rich protein 4	ERICH4 C19orf69	Homo sapiens (Human)	130							
A6NGU7	reviewed	CX028_HUMAN	Putative uncharacterized protein encoded by LINC01546	LINC01546 CXorf28	Homo sapiens (Human)	62							
A6NGW2	reviewed	STRCL_HUMAN	Putative stereocilin-like protein (Stereocilin pseudogene 1)	STRCP1 STRCP	Homo sapiens (Human)	1772			cell-matrix adhesion [GO:0007160]	cell surface [GO:0009986]; extracellular region [GO:0005576]; kinocilium [GO:0060091]; stereocilium tip [GO:0032426]		cell surface [GO:0009986]; extracellular region [GO:0005576]; kinocilium [GO:0060091]; stereocilium tip [GO:0032426]; cell-matrix adhesion [GO:0007160]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A6NGY1	reviewed	FRG2C_HUMAN	Protein FRG2-like-2 (FSHD region gene 2 protein family member C) (HSA3-FRG2)	FRG2C	Homo sapiens (Human)	282				nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
A6NGZ8	reviewed	SMIM9_HUMAN	Small integral membrane protein 9	SMIM9 CXorf68	Homo sapiens (Human)	99				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A6NH11	reviewed	GLTD2_HUMAN	Glycolipid transfer protein domain-containing protein 2	GLTPD2	Homo sapiens (Human)	291			ceramide transport [GO:0035627]; intermembrane lipid transfer [GO:0120009]	cytosol [GO:0005829]	ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]	cytosol [GO:0005829]; ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ceramide transport [GO:0035627]; intermembrane lipid transfer [GO:0120009]	
A6NH13	reviewed	DAS1_HUMAN	Putative uncharacterized protein DNAJC9-AS1 (DNAJC9 antisense RNA 1) (DNAJC9 antisense gene protein 1)	DNAJC9-AS1 C10orf103	Homo sapiens (Human)	148							
A6NHG4	reviewed	DDTL_HUMAN	D-dopachrome decarboxylase-like protein (EC 4.1.1.-) (D-dopachrome tautomerase-like protein)	DDTL	Homo sapiens (Human)	134	FUNCTION: May have lyase activity. {ECO:0000305}.			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]	lyase activity [GO:0016829]; phenylpyruvate tautomerase activity [GO:0050178]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lyase activity [GO:0016829]; phenylpyruvate tautomerase activity [GO:0050178]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
A6NHN6	reviewed	NPB15_HUMAN	Nuclear pore complex-interacting protein family member B15 (Nuclear pore complex-interacting protein-like 2)	NPIPB15 NPIPL2	Homo sapiens (Human)	443				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A6NHP3	reviewed	SPE2B_HUMAN	Speedy protein E2B	SPDYE2B	Homo sapiens (Human)	402					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
A6NHY2	reviewed	AKD1B_HUMAN	Ankyrin repeat and death domain-containing protein 1B	ANKDD1B	Homo sapiens (Human)	528			signal transduction [GO:0007165]			signal transduction [GO:0007165]	
A6NHZ5	reviewed	LR14B_HUMAN	Leucine-rich repeat-containing protein 14B	LRRC14B	Homo sapiens (Human)	514				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
A6NI47	reviewed	POTEM_HUMAN	Putative POTE ankyrin domain family member M	POTEM	Homo sapiens (Human)	508							
A6NI56	reviewed	CC154_HUMAN	Coiled-coil domain-containing protein 154	CCDC154 C16orf29	Homo sapiens (Human)	667		MISCELLANEOUS: Overexpression suppresses cell proliferation by inducing G2/M arrest. {ECO:0000305|PubMed:22895184}.	bone mineralization involved in bone maturation [GO:0035630]; bone resorption [GO:0045453]; odontogenesis of dentin-containing tooth [GO:0042475]; tooth eruption [GO:0044691]	early endosome [GO:0005769]		early endosome [GO:0005769]; bone mineralization involved in bone maturation [GO:0035630]; bone resorption [GO:0045453]; odontogenesis of dentin-containing tooth [GO:0042475]; tooth eruption [GO:0044691]	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:22895184}.
A6NI86	reviewed	GG6LA_HUMAN	Golgin subfamily A member 6-like protein 10	GOLGA6L10 GOLGA6L18	Homo sapiens (Human)	522							
A6NI87	reviewed	CBY3_HUMAN	Protein chibby homolog 3	CBY3	Homo sapiens (Human)	242		MISCELLANEOUS: 'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.					
A6NIE6	reviewed	RN3P2_HUMAN	Putative RRN3-like protein RRN3P2 (RNA polymerase I transcription factor homolog pseudogene 2)	RRN3P2	Homo sapiens (Human)	340			transcription initiation at RNA polymerase I promoter [GO:0006361]	nucleus [GO:0005634]	RNA polymerase I core binding [GO:0001042]; RNA polymerase I general transcription initiation factor activity [GO:0001181]	nucleus [GO:0005634]; RNA polymerase I core binding [GO:0001042]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; transcription initiation at RNA polymerase I promoter [GO:0006361]	
A6NIJ5	reviewed	F90AK_HUMAN	Putative protein FAM90A20P	FAM90A20P FAM90A20	Homo sapiens (Human)	464							
A6NIK2	reviewed	LR10B_HUMAN	Leucine-rich repeat-containing protein 10B	LRRC10B	Homo sapiens (Human)	292							
A6NIN4	reviewed	RN227_HUMAN	RING finger protein 227 (Long intergenic non-protein coding RNA 2581)	RNF227 LINC02581	Homo sapiens (Human)	190			protein ubiquitination [GO:0016567]		metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]	
A6NIV6	reviewed	LRIQ4_HUMAN	Leucine-rich repeat and IQ domain-containing protein 4 (Leucine-rich repeat-containing protein 64)	LRRIQ4 LRRC64	Homo sapiens (Human)	560							
A6NIY4	reviewed	SPDE5_HUMAN	Speedy protein E5	SPDYE5	Homo sapiens (Human)	402					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
A6NJ08	reviewed	MB3L5_HUMAN	Putative methyl-CpG-binding domain protein 3-like 5 (MBD3-like protein 5)	MBD3L5	Homo sapiens (Human)	208		MISCELLANEOUS: The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.	DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	methyl-CpG binding [GO:0008327]	nucleus [GO:0005634]; methyl-CpG binding [GO:0008327]; DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
A6NJ64	reviewed	NPIB2_HUMAN	Putative nuclear pore complex-interacting protein family member B2	NPIPB2	Homo sapiens (Human)	397				nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
A6NJ69	reviewed	IGIP_HUMAN	IgA-inducing protein homolog	IGIP C5orf53	Homo sapiens (Human)	53	FUNCTION: Enhances IgA secretion from B-cells stimulated via CD40. {ECO:0000250}.			extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
A6NJ88	reviewed	SGE2P_HUMAN	Putative SAGE1-like protein (Sarcoma antigen 2 pseudogene)	SAGE2P	Homo sapiens (Human)	616			snRNA 3'-end processing [GO:0034472]	integrator complex [GO:0032039]		integrator complex [GO:0032039]; snRNA 3'-end processing [GO:0034472]	
A6NJG2	reviewed	SWAHD_HUMAN	Ankyrin repeat domain-containing protein SOWAHD (Ankyrin repeat domain-containing protein 58) (Protein sosondowah homolog D)	SOWAHD ANKRD58	Homo sapiens (Human)	315							
A6NJJ6	reviewed	CS067_HUMAN	UPF0575 protein C19orf67	C19orf67	Homo sapiens (Human)	358							
A6NJQ4	reviewed	F90A8_HUMAN	Putative protein FAM90A8	FAM90A8 FAM90A8P	Homo sapiens (Human)	464							
A6NJU9	reviewed	NPB13_HUMAN	Nuclear pore complex-interacting protein family member B13	NPIPB13	Homo sapiens (Human)	1138				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A6NJY1	reviewed	SL9P1_HUMAN	Putative SLC9B1-like protein SLC9B1P1 (Solute carrier family 9 subfamily B member 1 pseudogene 1)	SLC9B1P1	Homo sapiens (Human)	282			proton transmembrane transport [GO:1902600]	membrane [GO:0016020]	antiporter activity [GO:0015297]	membrane [GO:0016020]; antiporter activity [GO:0015297]; proton transmembrane transport [GO:1902600]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NK44	reviewed	GLOD5_HUMAN	Glyoxalase domain-containing protein 5	GLOD5	Homo sapiens (Human)	160							
A6NKC0	reviewed	F90A7_HUMAN	Putative protein FAM90A7	FAM90A7 FAM90A7P	Homo sapiens (Human)	464							
A6NKC9	reviewed	SH2D7_HUMAN	SH2 domain-containing protein 7	SH2D7	Homo sapiens (Human)	451				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
A6NKF7	reviewed	TM88B_HUMAN	Transmembrane protein 88B	TMEM88B	Homo sapiens (Human)	163			negative regulation of canonical Wnt signaling pathway [GO:0090090]	plasma membrane [GO:0005886]	PDZ domain binding [GO:0030165]	plasma membrane [GO:0005886]; PDZ domain binding [GO:0030165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NKH3	reviewed	RL37L_HUMAN	Putative ribosomal protein eL43-like (Putative 60S ribosomal protein L37a-like protein) (Ribosomal protein L37a pseudogene 8)	RPL37AP8 RPL37L	Homo sapiens (Human)	93			translation [GO:0006412]	cytosolic large ribosomal subunit [GO:0022625]	metal ion binding [GO:0046872]; structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]; metal ion binding [GO:0046872]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]	
A6NKL6	reviewed	T200C_HUMAN	Transmembrane protein 200C (Transmembrane protein TTMA) (Two transmembrane domain-containing family member A)	TMEM200C TTMA	Homo sapiens (Human)	621				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NKN8	reviewed	PC4L1_HUMAN	Purkinje cell protein 4-like protein 1 (PCP4-like protein 1)	PCP4L1 IQM1	Homo sapiens (Human)	68							
A6NKP2	reviewed	D42E2_HUMAN	Putative short-chain dehydrogenase/reductase family 42E member 2 (EC 1.1.1.-)	SDR42E2	Homo sapiens (Human)	422			steroid biosynthetic process [GO:0006694]		3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid biosynthetic process [GO:0006694]	
A6NKU9	reviewed	SPDE3_HUMAN	Speedy protein E3	SPDYE3	Homo sapiens (Human)	549					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
A6NKW6	reviewed	SHL2B_HUMAN	Protein shisa-like-2B	SHISAL2B FAM159B	Homo sapiens (Human)	160				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A6NKX4	reviewed	S22AV_HUMAN	Putative solute carrier family 22 member 31	SLC22A31	Homo sapiens (Human)	556	FUNCTION: Organic anion transporter that mediates the uptake of ions. {ECO:0000305}.		monoatomic ion transport [GO:0006811]	membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]; monoatomic ion transport [GO:0006811]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A6NL05	reviewed	F74A7_HUMAN	Protein FAM74A7	FAM74A7	Homo sapiens (Human)	159				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A6NLC5	reviewed	CC070_HUMAN	UPF0524 protein C3orf70	C3orf70	Homo sapiens (Human)	250	FUNCTION: May play a role in neuronal and neurobehavioral development. {ECO:0000250|UniProtKB:Q1LY84}.		circadian behavior [GO:0048512]; nervous system development [GO:0007399]			circadian behavior [GO:0048512]; nervous system development [GO:0007399]	
A6NLC8	reviewed	TFKL2_HUMAN	TATA-box binding protein associated factor 11 like protein 2	TAF11L2	Homo sapiens (Human)	198			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
A6NLE4	reviewed	SIM23_HUMAN	Small integral membrane protein 23	SMIM23 C5orf50	Homo sapiens (Human)	172				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
A6NLU5	reviewed	VTM2B_HUMAN	V-set and transmembrane domain-containing protein 2B	VSTM2B	Homo sapiens (Human)	285				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A6NLX4	reviewed	TM210_HUMAN	Transmembrane protein 210	TMEM210	Homo sapiens (Human)	147				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
A6NM36	reviewed	LRC30_HUMAN	Leucine-rich repeat-containing protein 30	LRRC30	Homo sapiens (Human)	301			signal transduction [GO:0007165]			signal transduction [GO:0007165]	
A6NM62	reviewed	LRC53_HUMAN	Leucine-rich repeat-containing protein 53	LRRC53	Homo sapiens (Human)	1247				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A6NMA1	reviewed	TR5OS_HUMAN	Putative uncharacterized protein TRPC5OS (TRPC5 opposite strand protein) (TRPC5-antisense RNA 1)	TRPC5OS TRPC5-AS1	Homo sapiens (Human)	111							
A6NMB9	reviewed	FIGL2_HUMAN	Fidgetin-like protein 2	FIGNL2	Homo sapiens (Human)	653					ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568]	
A6NMD0	reviewed	IFM10_HUMAN	Interferon-induced transmembrane protein 10 (Dispanin subfamily A member 3) (DSPA3)	IFITM10	Homo sapiens (Human)	228				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
A6NMD2	reviewed	GOG8J_HUMAN	Golgin subfamily A member 8J	GOLGA8J	Homo sapiens (Human)	632			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
A6NMK7	reviewed	CPS4L_HUMAN	Putative cleavage and polyadenylation specificity factor subunit 4-like protein	CPSF4L	Homo sapiens (Human)	179				mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	
A6NMK8	reviewed	INY2B_HUMAN	Protein INSYN2B (Inhibitory synaptic factor family member 2B)	INSYN2B C5orf57 FAM196B	Homo sapiens (Human)	535			inhibitory postsynaptic potential [GO:0060080]	postsynaptic density [GO:0014069]		postsynaptic density [GO:0014069]; inhibitory postsynaptic potential [GO:0060080]	
A6NMZ2	reviewed	SNTAN_HUMAN	Sentan (Protein S100-A1-like) (S100 calcium-binding protein A1-like)	SNTN S100A1L	Homo sapiens (Human)	147	FUNCTION: May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules. {ECO:0000250}.	MISCELLANEOUS: 'Sentan' means 'tip' in Japanese.		cilium [GO:0005929]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914]	cilium [GO:0005929]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}. Note=Expressed exclusively at the cilium tip where it localizes between the cell membrane and peripheral A-subfibers. {ECO:0000250}.
A6NN90	reviewed	CB081_HUMAN	Uncharacterized protein C2orf81	C2orf81	Homo sapiens (Human)	582							
A6NNA2	reviewed	SRRM3_HUMAN	Serine/arginine repetitive matrix protein 3	SRRM3	Homo sapiens (Human)	597	FUNCTION: May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911). {ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:27748911}.			nucleus [GO:0005634]	mRNA binding [GO:0003729]	nucleus [GO:0005634]; mRNA binding [GO:0003729]	
A6NNC1	reviewed	P12LL_HUMAN	Putative POM121-like protein 1-like		Homo sapiens (Human)	897				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A6NNJ1	reviewed	F90A9_HUMAN	Putative protein FAM90A9	FAM90A9 FAM90A9P	Homo sapiens (Human)	464							
A6NNL0	reviewed	NTM2B_HUMAN	NUT family member 2B	NUTM2B FAM22B	Homo sapiens (Human)	878							
A6NNL5	reviewed	CO061_HUMAN	Uncharacterized protein C15orf61	C15orf61	Homo sapiens (Human)	157				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A6NNT2	reviewed	CP096_HUMAN	Uncharacterized protein C16orf96	C16orf96	Homo sapiens (Human)	1141							
A6NNV3	reviewed	SPD16_HUMAN	Putative speedy protein E16	SPDYE16	Homo sapiens (Human)	312					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
A6PVI3	reviewed	NCB2L_HUMAN	Nuclear cap-binding protein subunit 2-like	NCBP2L	Homo sapiens (Human)	153			mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]	nuclear cap binding complex [GO:0005846]	RNA cap binding [GO:0000339]	nuclear cap binding complex [GO:0005846]; RNA cap binding [GO:0000339]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]	
A6PVY3	reviewed	F177B_HUMAN	Protein FAM177B	FAM177B	Homo sapiens (Human)	158							
A7E2S9	reviewed	A30BL_HUMAN	Putative ankyrin repeat domain-containing protein 30B-like	ANKRD30BL NCRNA00164	Homo sapiens (Human)	258		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
A8K010	reviewed	CF176_HUMAN	Putative transcriptional regulator encoded by LINC00473	LINC00473 C6orf176	Homo sapiens (Human)	186	FUNCTION: May play a role in cAMP-mediated gene transcription. {ECO:0000269|PubMed:22108211}.		DNA-templated transcription [GO:0006351]			DNA-templated transcription [GO:0006351]	
A8MQ11	reviewed	PM2P5_HUMAN	Postmeiotic segregation increased 2-like protein 5 (Postmeiotic segregation increased protein 4) (Postmeiotic segregation increased protein 7) (Putative postmeiotic segregation increased 2 pseudogene 5)	PMS2P5 PMS2L5 PMS4 PMS7	Homo sapiens (Human)	134		MISCELLANEOUS: Encoded by one of the numerous copies of postmeiotic segregation increased 2-like genes scattered in the q11-q22 region of the chromosome 7.	mismatch repair [GO:0006298]	mismatch repair complex [GO:0032300]	ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]	mismatch repair complex [GO:0032300]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatch repair [GO:0006298]	
A8MQ14	reviewed	ZN850_HUMAN	Zinc finger protein 850	ZNF850	Homo sapiens (Human)	1090	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
A8MQB3	reviewed	CQ051_HUMAN	Putative uncharacterized protein LINC02693	LINC02693 C17orf51	Homo sapiens (Human)	221							
A8MRT5	reviewed	NPIB5_HUMAN	Nuclear pore complex-interacting protein family member B5	NPIPB5	Homo sapiens (Human)	1133				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A8MSI8	reviewed	LYRM9_HUMAN	LYR motif-containing protein 9	LYRM9 C17orf108 HSD24	Homo sapiens (Human)	78							
A8MT19	reviewed	RHN2P_HUMAN	Putative rhophilin-2-like protein RHPN2P1 (Rhophilin-2 pseudogene 1)	RHPN2P1	Homo sapiens (Human)	583			negative regulation of stress fiber assembly [GO:0051497]			negative regulation of stress fiber assembly [GO:0051497]	
A8MT33	reviewed	SYC1L_HUMAN	Synaptonemal complex central element protein 1-like (Meiosis-related protein)	SYCE1L	Homo sapiens (Human)	242	FUNCTION: May be involved in meiosis. {ECO:0000250}.		synaptonemal complex assembly [GO:0007130]	intermediate filament cytoskeleton [GO:0045111]; synaptonemal complex [GO:0000795]		intermediate filament cytoskeleton [GO:0045111]; synaptonemal complex [GO:0000795]; synaptonemal complex assembly [GO:0007130]	
A8MT65	reviewed	ZN891_HUMAN	Zinc finger protein 891	ZNF891	Homo sapiens (Human)	544	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
A8MTB9	reviewed	CEA18_HUMAN	Carcinoembryonic antigen-related cell adhesion molecule 18	CEACAM18	Homo sapiens (Human)	384							
A8MTL3	reviewed	R212B_HUMAN	RING finger protein 212B	RNF212B C14orf164	Homo sapiens (Human)	300			homologous chromosome pairing at meiosis [GO:0007129]; protein sumoylation [GO:0016925]; reciprocal meiotic recombination [GO:0007131]	synaptonemal complex [GO:0000795]	metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789]	synaptonemal complex [GO:0000795]; metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789]; homologous chromosome pairing at meiosis [GO:0007129]; protein sumoylation [GO:0016925]; reciprocal meiotic recombination [GO:0007131]	
A8MTT3	reviewed	CEBOS_HUMAN	Protein CEBPZOS (CEBPZ antisense RNA 1) (CEBPZ opposite strand)	CEBPZOS CEBPZ-AS1	Homo sapiens (Human)	80				mitochondrial membrane [GO:0031966]		mitochondrial membrane [GO:0031966]	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:25002142}; Single-pass membrane protein {ECO:0000255}.
A8MTY0	reviewed	ZN724_HUMAN	Zinc finger protein 724	ZNF724 ZNF724P	Homo sapiens (Human)	619	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A8MUL3	reviewed	ADAS1_HUMAN	Putative uncharacterized protein ADARB2-AS1 (ADARB2 antisense RNA 1) (ADARB2 antisense gene protein 1)	ADARB2-AS1 C10orf109 NCRNA00168	Homo sapiens (Human)	147							
A8MUP6	reviewed	GS1L2_HUMAN	Germ cell-specific gene 1-like protein 2 (GSG1-like protein 2)	GSG1L2	Homo sapiens (Human)	293				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A8MUU1	reviewed	FB5L3_HUMAN	Putative fatty acid-binding protein 5-like protein 3 (Fatty acid-binding protein 5 pseudogene 3)	FABP5P3 FABP5L3	Homo sapiens (Human)	101	FUNCTION: High specificity for fatty acids. {ECO:0000250}.		fatty acid transport [GO:0015908]	cytosol [GO:0005829]; nucleus [GO:0005634]	fatty acid binding [GO:0005504]	cytosol [GO:0005829]; nucleus [GO:0005634]; fatty acid binding [GO:0005504]; fatty acid transport [GO:0015908]	
A8MUX0	reviewed	KR161_HUMAN	Keratin-associated protein 16-1	KRTAP16-1 KAP16.1	Homo sapiens (Human)	517				cytosol [GO:0005829]; keratin filament [GO:0045095]		cytosol [GO:0005829]; keratin filament [GO:0045095]	
A8MUZ8	reviewed	Z705G_HUMAN	Putative zinc finger protein 705G	ZNF705G	Homo sapiens (Human)	300	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
A8MV57	reviewed	MPTX_HUMAN	Putative mucosal pentraxin homolog	MPTX1 MPTX	Homo sapiens (Human)	137					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
A8MVJ9	reviewed	HPF1L_HUMAN	Putative histone PARylation factor 1-like		Homo sapiens (Human)	347			DNA damage response [GO:0006974]	nucleus [GO:0005634]	histone binding [GO:0042393]; poly-ADP-D-ribose binding [GO:0072572]	nucleus [GO:0005634]; histone binding [GO:0042393]; poly-ADP-D-ribose binding [GO:0072572]; DNA damage response [GO:0006974]	
A8MVX0	reviewed	ARG33_HUMAN	Rho guanine nucleotide exchange factor 33	ARHGEF33	Homo sapiens (Human)	844	FUNCTION: May act as a guanine-nucleotide releasing factor. {ECO:0000250}.				guanyl-nucleotide exchange factor activity [GO:0005085]	guanyl-nucleotide exchange factor activity [GO:0005085]	
A8MWA6	reviewed	F90AM_HUMAN	Putative protein FAM90A22	FAM90A22 FAM90A22P	Homo sapiens (Human)	464							
A8MWL6	reviewed	SNG2L_HUMAN	Putative synaptogyrin-2 like protein		Homo sapiens (Human)	223				neuromuscular junction [GO:0031594]; synaptic vesicle membrane [GO:0030672]		neuromuscular junction [GO:0031594]; synaptic vesicle membrane [GO:0030672]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
A8MWL7	reviewed	TM14D_HUMAN	Transmembrane protein 14DP	TMEM14DP TMEM14D	Homo sapiens (Human)	114			regulation of heme biosynthetic process [GO:0070453]	mitochondrial membrane [GO:0031966]		mitochondrial membrane [GO:0031966]; regulation of heme biosynthetic process [GO:0070453]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A8MWV9	reviewed	SM34A_HUMAN	Small integral membrane protein 34	SMIM34 SMIM34A	Homo sapiens (Human)	139				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A8MX19	reviewed	F90AC_HUMAN	Putative protein FAM90A12P	FAM90A12P FAM90A12	Homo sapiens (Human)	464							
A8MX34	reviewed	KR291_HUMAN	Keratin-associated protein 29-1 (Keratin-associated protein 29.2)	KRTAP29-1 KAP29.2	Homo sapiens (Human)	341				cytosol [GO:0005829]; keratin filament [GO:0045095]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; keratin filament [GO:0045095]; structural molecule activity [GO:0005198]	
A8MXJ8	reviewed	F90A5_HUMAN	Putative protein FAM90A5P	FAM90A5P FAM90A5	Homo sapiens (Human)	464							
A8MXQ7	reviewed	IQAK1_HUMAN	IQ motif and ankyrin repeat domain-containing protein 1	IQANK1	Homo sapiens (Human)	560							
A8MXT2	reviewed	MAGBH_HUMAN	Melanoma-associated antigen B17	MAGEB17	Homo sapiens (Human)	336			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
A8MXV6	reviewed	CD15L_HUMAN	CMT1A duplicated region transcript 15 protein-like protein	CDRT15L2	Homo sapiens (Human)	281				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A8MXZ1	reviewed	F90AN_HUMAN	Putative protein FAM90A23	FAM90A23 FAM90A23P	Homo sapiens (Human)	464							
A8MYA2	reviewed	CX049_HUMAN	Uncharacterized protein CXorf49	CXorf49; CXorf49B	Homo sapiens (Human)	514							
A8MYB1	reviewed	TMC5B_HUMAN	Transmembrane and coiled-coil domain-containing protein 5B	TMCO5B	Homo sapiens (Human)	307				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A8MYZ0	reviewed	MIY4B_HUMAN	Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B (Protein FAM188B2)	MINDY4B C3orf76 FAM188B2	Homo sapiens (Human)	460					cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]	cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]	
A8MZ36	reviewed	EVPLL_HUMAN	Envoplakin-like protein	EVPLL	Homo sapiens (Human)	301			intermediate filament cytoskeleton organization [GO:0045104]			intermediate filament cytoskeleton organization [GO:0045104]	
A8MZ97	reviewed	CB074_HUMAN	Uncharacterized protein C2orf74	C2orf74	Homo sapiens (Human)	187				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
A8MZA4	reviewed	GG6L6_HUMAN	Golgin subfamily A member 6-like protein 6	GOLGA6L6	Homo sapiens (Human)	724							
A8MZH6	reviewed	OOSP1_HUMAN	Putative oocyte-secreted protein 1 homolog	OOSP1	Homo sapiens (Human)	123	FUNCTION: May be involved in cell differentiation. {ECO:0000250}.			extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
B0FP48	reviewed	UPK3L_HUMAN	Uroplakin-3b-like protein 1	UPK3BL1 UPLP	Homo sapiens (Human)	263				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
B1AH88	reviewed	TSPOB_HUMAN	Putative peripheral benzodiazepine receptor-related protein	TSPO PBRS	Homo sapiens (Human)	102		MISCELLANEOUS: [Isoform 2]: The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support.					
B1AK76	reviewed	SNUFL_HUMAN	Putative SNURF-like protein	SNURFL CXorf19	Homo sapiens (Human)	121				nuclear speck [GO:0016607]		nuclear speck [GO:0016607]	
B1AL46	reviewed	NTM2E_HUMAN	NUT family member 2E	NUTM2E FAM22E	Homo sapiens (Human)	878							
B1ANH7	reviewed	IBADT_HUMAN	Putative uncharacterized protein IBA57-DT (IBA57 antisense RNA 1) (IBA57 antisense gene protein 1) (IBA57 divergent transcripte)	IBA57-DT C1orf148 IBA57-AS1	Homo sapiens (Human)	110							
B1ANS9	reviewed	WDR64_HUMAN	WD repeat-containing protein 64	WDR64	Homo sapiens (Human)	1081							
B1ANY3	reviewed	F220P_HUMAN	Putative protein FAM220BP (Protein FAM220B pseudogene)	FAM220BP C9orf51	Homo sapiens (Human)	271			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	STAT family protein binding [GO:0097677]	nucleus [GO:0005634]; STAT family protein binding [GO:0097677]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
B1ATL7	reviewed	PRR32_HUMAN	Proline-rich protein 32	PRR32 CXorf64	Homo sapiens (Human)	298							
B2RBV5	reviewed	MR1L2_HUMAN	MORF4 family associated protein 1 like 2 (MORF4 family-associated protein 1-like protein UPP) (Unnamed protein product) (UPP)	MRFAP1L2	Homo sapiens (Human)	119	FUNCTION: May play a role in cell proliferation. {ECO:0000305|PubMed:24248101}.		regulation of cell cycle [GO:0051726]			regulation of cell cycle [GO:0051726]	
B2RD01	reviewed	CENP1_HUMAN	Putative CENPB DNA-binding domain-containing protein 1	CENPBD1P CENPBD1	Homo sapiens (Human)	187				nucleus [GO:0005634]	DNA binding [GO:0003677]	nucleus [GO:0005634]; DNA binding [GO:0003677]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000255|PROSITE-ProRule:PRU00583}.
B2RV13	reviewed	CF97D_HUMAN	Sperm axonemal maintenance protein CFAP97D1 (CFAP97 domain-containing protein 1)	CFAP97D1 C17orf105	Homo sapiens (Human)	164	FUNCTION: Required for male fertility through its role in axonemal doublet stabilization which is essential for sperm motility and fertilization. {ECO:0000250|UniProtKB:Q9DAN9}.		sperm axoneme assembly [GO:0007288]			sperm axoneme assembly [GO:0007288]	
B2RXF0	reviewed	T229A_HUMAN	Transmembrane protein 229A	TMEM229A	Homo sapiens (Human)	380				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
B3GLJ2	reviewed	PATE3_HUMAN	Prostate and testis expressed protein 3 (Acrosomal vesicle protein HEL-127) (PATE-like protein DJ) (PATE-DJ)	PATE3	Homo sapiens (Human)	98				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
B3KS81	reviewed	SRRM5_HUMAN	Serine/arginine repetitive matrix protein 5	SRRM5 ZNF576	Homo sapiens (Human)	715							
B4DH59	reviewed	NBPFP_HUMAN	Neuroblastoma breakpoint family member 26	NBPF26	Homo sapiens (Human)	902		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
B4DJY2	reviewed	TM233_HUMAN	Transmembrane protein 233 (Dispanin subfamily B member 2) (DSPB2) (Interferon-induced transmembrane domain-containing protein D2)	TMEM233 IFITMD2	Homo sapiens (Human)	109				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
B4DX44	reviewed	ZN736_HUMAN	Zinc finger protein 736	ZNF736	Homo sapiens (Human)	427	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
B4DXR9	reviewed	ZN732_HUMAN	Zinc finger protein 732	ZNF732	Homo sapiens (Human)	585	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
B4DZS4	reviewed	T11X1_HUMAN	T-complex protein 11 X-linked protein 1	TCP11X1	Homo sapiens (Human)	312			protein kinase A signaling [GO:0010737]; regulation of sperm capacitation [GO:1902490]	acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126]		acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126]; protein kinase A signaling [GO:0010737]; regulation of sperm capacitation [GO:1902490]	
B4E2M5	reviewed	ANR66_HUMAN	Ankyrin repeat domain-containing protein 66	ANKRD66	Homo sapiens (Human)	196							
B5MCN3	reviewed	S14L6_HUMAN	Putative SEC14-like protein 6	SEC14L6	Homo sapiens (Human)	397				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
B5MD39	reviewed	GGTL3_HUMAN	Putative glutathione hydrolase light chain 3 (Putative gamma-glutamyltransferase light chain 3)	GGTLC3	Homo sapiens (Human)	225		MISCELLANEOUS: Corresponds to the light chain of other gamma-glutamyltransferase family members. Has no catalytic activity.	glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]	extracellular exosome [GO:0070062]	glutathione hydrolase activity [GO:0036374]	extracellular exosome [GO:0070062]; glutathione hydrolase activity [GO:0036374]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]	
B6SEH8	reviewed	ERVV1_HUMAN	Endogenous retrovirus group V member 1 Env polyprotein (HERV-V_19q13.41 provirus ancestral Env polyprotein 1)	ERVV-1 ENVV1	Homo sapiens (Human)	477				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
B6SEH9	reviewed	ERVV2_HUMAN	Endogenous retrovirus group V member 2 Env polyprotein (HERV-V_19q13.41 provirus ancestral Env polyprotein 2)	ERVV-2 ENVV2	Homo sapiens (Human)	535				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
B7Z1M9	reviewed	C2D4D_HUMAN	C2 calcium-dependent domain-containing protein 4D	C2CD4D FAM148D	Homo sapiens (Human)	353							
B7Z368	reviewed	CJ142_HUMAN	Uncharacterized protein encoded by LINC02881 (Long intergenic non-protein coding RNA 2881)	LINC02881 C10orf142	Homo sapiens (Human)	130							
B7Z6K7	reviewed	ZN814_HUMAN	Zinc finger protein 814	ZNF814	Homo sapiens (Human)	855			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	
B7ZBB8	reviewed	PP13G_HUMAN	Protein phosphatase 1 regulatory subunit 3G	PPP1R3G	Homo sapiens (Human)	358	FUNCTION: Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity). {ECO:0000250}.		glucose homeostasis [GO:0042593]; glycogen biosynthetic process [GO:0005978]; positive regulation of glycogen biosynthetic process [GO:0045725]; regulation of glycogen biosynthetic process [GO:0005979]	protein phosphatase type 1 complex [GO:0000164]	glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]	protein phosphatase type 1 complex [GO:0000164]; glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; glucose homeostasis [GO:0042593]; glycogen biosynthetic process [GO:0005978]; positive regulation of glycogen biosynthetic process [GO:0045725]; regulation of glycogen biosynthetic process [GO:0005979]	
B7ZW38	reviewed	HNRC3_HUMAN	Heterogeneous nuclear ribonucleoprotein C-like 3	HNRNPCL3	Homo sapiens (Human)	293				nucleus [GO:0005634]	RNA binding [GO:0003723]	nucleus [GO:0005634]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P07910}.
B9A6J9	reviewed	TBC3L_HUMAN	TBC1 domain family member 3L	TBC1D3L	Homo sapiens (Human)	549	FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250|UniProtKB:Q8IZP1}.	MISCELLANEOUS: TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor. {ECO:0000305}.		plasma membrane [GO:0005886]	GTPase activator activity [GO:0005096]	plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IZP1}; Lipid-anchor {ECO:0000250|UniProtKB:Q8IZP1}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:Q8IZP1}.
C0HLS1	reviewed	OSCRI_HUMAN	SCRIB overlapping open reading frame protein (oSCRIB)	SCRIB	Homo sapiens (Human)	120	FUNCTION: Represses translation of the downstream SCRIB protein (PubMed:34535749). Translation of oSCRIB hinders SCRIB translation but does not completely abolish it, probably due to leaky scanning which allows the ribosome to bypass the weaker oSCRIB start codon and initiate translation at the stronger SCRIB start codon (PubMed:34535749). {ECO:0000269|PubMed:34535749}.	MISCELLANEOUS: This protein is produced by a polycistronic gene which also produces the tumor suppressor gene SCRIB from an overlapping reading frame. {ECO:0000269|PubMed:34535749}.	negative regulation of translational initiation [GO:0045947]			negative regulation of translational initiation [GO:0045947]	
C9J202	reviewed	AG1L2_HUMAN	Putative glycosyltransferase ALG1L2 (EC 2.4.1.-)	ALG1L2	Homo sapiens (Human)	215	FUNCTION: Putative glycosyltransferase. {ECO:0000250}.		protein glycosylation [GO:0006486]	endoplasmic reticulum [GO:0005783]	mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; mannosyltransferase activity [GO:0000030]; protein glycosylation [GO:0006486]	
C9J3V5	reviewed	TEX22_HUMAN	Testis-expressed protein 22	TEX22	Homo sapiens (Human)	150				acrosomal vesicle [GO:0001669]		acrosomal vesicle [GO:0001669]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.
C9J7I0	reviewed	UMAD1_HUMAN	UBAP1-MVB12-associated (UMA)-domain containing protein 1 (RPA3 antisense RNA 1) (RPA3 opposite strand)	UMAD1 RPA3-AS1 RPA3OS	Homo sapiens (Human)	137							
C9JBD0	reviewed	KRBX1_HUMAN	KRAB domain-containing protein 1	KRBOX1	Homo sapiens (Human)	128			regulation of DNA-templated transcription [GO:0006355]			regulation of DNA-templated transcription [GO:0006355]	
C9JG80	reviewed	NPIB4_HUMAN	Nuclear pore complex-interacting protein family member B4	NPIPB4	Homo sapiens (Human)	1138				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
C9JI98	reviewed	TM238_HUMAN	Transmembrane protein 238	TMEM238	Homo sapiens (Human)	176				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
C9JJ37	reviewed	BTBDJ_HUMAN	BTB/POZ domain-containing protein 19	BTBD19	Homo sapiens (Human)	291							
C9JL84	reviewed	HHLA1_HUMAN	HERV-H LTR-associating protein 1	HHLA1	Homo sapiens (Human)	531		MISCELLANEOUS: [Isoform 2]: Expressed in teratocarcinoma cell lines. {ECO:0000305}.		extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
C9JN71	reviewed	ZN878_HUMAN	Zinc finger protein 878	ZNF878	Homo sapiens (Human)	531	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
C9JQI7	reviewed	TM232_HUMAN	Transmembrane protein 232	TMEM232	Homo sapiens (Human)	657	FUNCTION: Plays a critical role for male fertility and sperm motility by regulating sperm cytoplasm removal and maintaining axoneme integrity. {ECO:0000250|UniProtKB:Q5K6N0}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
C9JTQ0	reviewed	ANR63_HUMAN	Ankyrin repeat domain-containing protein 63	ANKRD63	Homo sapiens (Human)	380							
C9JVW0	reviewed	INAM1_HUMAN	Putative transmembrane protein INAFM1 (InaF-motif-containing protein 1) (Proline-rich protein 24)	INAFM1 PRR24	Homo sapiens (Human)	142				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
D3DTV9	reviewed	PRAC2_HUMAN	Putative protein PRAC2 (Prostate, rectum and colon expressed gene protein 2)	PRAC2 C17orf93 HOXB-AS5 HOXB13-AS1 NCRNA00253	Homo sapiens (Human)	90				nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12746837}.
D6RBM5	reviewed	U17LN_HUMAN	Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23	USP17L23	Homo sapiens (Human)	183				endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	cysteine-type deubiquitinase activity [GO:0004843]	endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type deubiquitinase activity [GO:0004843]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
D6REC4	reviewed	CFA99_HUMAN	Cilia- and flagella-associated protein 99	CFAP99	Homo sapiens (Human)	714				motile cilium [GO:0031514]		motile cilium [GO:0031514]	SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A8IUG5}.
D6RF30	reviewed	GOG8K_HUMAN	Golgin subfamily A member 8K	GOLGA8K	Homo sapiens (Human)	630			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
D6RGX4	reviewed	F90AP_HUMAN	Putative protein FAM90A26	FAM90A26 FAM90A26P	Homo sapiens (Human)	464							
E5RG02	reviewed	PRS46_HUMAN	Putative serine protease 46 (EC 3.4.21.-) (Serine protease 46 pseudogene)	PRSS46P PRSS46	Homo sapiens (Human)	174			proteolysis [GO:0006508]		serine-type endopeptidase activity [GO:0004252]	serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]	
E5RHQ5	reviewed	NPB11_HUMAN	Nuclear pore complex-interacting protein family member B11	NPIPB11	Homo sapiens (Human)	1161				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
E5RIL1	reviewed	UPKL2_HUMAN	Uroplakin-3b-like protein 2	UPK3BL2	Homo sapiens (Human)	263				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
E5RJ46	reviewed	CH087_HUMAN	Putative uncharacterized protein LINC02906 (Long intergenic non-protein coding RNA 2906)	LINC02906 C8orf87	Homo sapiens (Human)	101							
E5RJM6	reviewed	ANR65_HUMAN	Ankyrin repeat domain-containing protein 65	ANKRD65	Homo sapiens (Human)	399							
E5RQL4	reviewed	FONG_HUMAN	Formiminotransferase N-terminal subdomain-containing protein (Formiminotransferase-cyclodeaminase N-terminal-like protein)	FTCDNL1 FONG	Homo sapiens (Human)	147				intracellular membrane-bounded organelle [GO:0043231]	folic acid binding [GO:0005542]; transferase activity [GO:0016740]	intracellular membrane-bounded organelle [GO:0043231]; folic acid binding [GO:0005542]; transferase activity [GO:0016740]	
E7ERA6	reviewed	RN223_HUMAN	RING finger protein 223	RNF223	Homo sapiens (Human)	249			protein ubiquitination [GO:0016567]	membrane [GO:0016020]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
E7EW31	reviewed	PROB1_HUMAN	Proline-rich basic protein 1	PROB1 C5orf65	Homo sapiens (Human)	1015				nucleoplasm [GO:0005654]		nucleoplasm [GO:0005654]	
E9PGG2	reviewed	ANHX_HUMAN	Anomalous homeobox protein	ANHX	Homo sapiens (Human)	379			regulation of skeletal muscle cell proliferation [GO:0014857]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle fiber development [GO:0048741]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of skeletal muscle cell proliferation [GO:0014857]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle fiber development [GO:0048741]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
E9PI22	reviewed	P23D1_HUMAN	Proline-rich protein 23D1	PRR23D1	Homo sapiens (Human)	279							
E9PIF3	reviewed	NPIA2_HUMAN	Nuclear pore complex-interacting protein family member A2	NPIPA2	Homo sapiens (Human)	369							
E9PJ23	reviewed	NPIB6_HUMAN	Nuclear pore complex-interacting protein family member B6	NPIPB6	Homo sapiens (Human)	425							
E9PJI5	reviewed	NPIA7_HUMAN	Nuclear pore complex-interacting protein family member A7	NPIPA7	Homo sapiens (Human)	369							
E9PKD4	reviewed	NPIA5_HUMAN	Nuclear pore complex-interacting protein family member A5	NPIPA5	Homo sapiens (Human)	350							
E9PQR5	reviewed	NPIB8_HUMAN	Nuclear pore complex-interacting protein family member B8	NPIPB8	Homo sapiens (Human)	432							
F2Z333	reviewed	FND10_HUMAN	Fibronectin type III domain-containing protein 10	FNDC10 C1orf233	Homo sapiens (Human)	226				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
F5GYI3	reviewed	UBA1L_HUMAN	Ubiquitin-associated protein 1-like (UBAP-1L)	UBAP1L	Homo sapiens (Human)	381			ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	ESCRT I complex [GO:0000813]	ubiquitin binding [GO:0043130]	ESCRT I complex [GO:0000813]; ubiquitin binding [GO:0043130]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	
F5H284	reviewed	PAL4D_HUMAN	Peptidyl-prolyl cis-trans isomerase A-like 4D (PPIase A-like 4D) (EC 5.2.1.8)	PPIAL4D	Homo sapiens (Human)	164	FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.	MISCELLANEOUS: It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1. {ECO:0000305}.	protein folding [GO:0006457]	cytoplasm [GO:0005737]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62937}.
F5H4A9	reviewed	CC080_HUMAN	Uncharacterized membrane protein C3orf80	C3orf80	Homo sapiens (Human)	247				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
F5H4B4	reviewed	F227A_HUMAN	Protein FAM227A	FAM227A	Homo sapiens (Human)	570							
F8W0I5	reviewed	NPB12_HUMAN	Nuclear pore complex-interacting protein family member B12	NPIPB12	Homo sapiens (Human)	928				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
F8W1W9	reviewed	NPIB9_HUMAN	Nuclear pore complex-interacting protein family member B9	NPIPB9	Homo sapiens (Human)	429							
F8WBI6	reviewed	GOG8N_HUMAN	Golgin subfamily A member 8N	GOLGA8N	Homo sapiens (Human)	632			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
F8WCM5	reviewed	INSR2_HUMAN	Insulin, isoform 2 (INS-IGF2 readthrough transcript protein)	INS-IGF2	Homo sapiens (Human)	200		MISCELLANEOUS: [Isoform 2]: Based on a readthrough transcript which may produce an INS-IGF2 fusion protein.		extracellular space [GO:0005615]	hormone activity [GO:0005179]	extracellular space [GO:0005615]; hormone activity [GO:0005179]	
F8WFD2	reviewed	NPIA3_HUMAN	Nuclear pore complex-interacting protein family member A3	NPIPA3	Homo sapiens (Human)	350							
G3V211	reviewed	CL079_HUMAN	Uncharacterized protein encoded by LINC01619	LINC01619 C12orf79	Homo sapiens (Human)	115							
H0UI37	reviewed	TSTD3_HUMAN	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3 (Rhodanese domain-containing protein 3)	TSTD3	Homo sapiens (Human)	97							
H0Y354	reviewed	FA72C_HUMAN	Protein FAM72C	FAM72C	Homo sapiens (Human)	149				cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]		cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]	
H0Y7S4	reviewed	PRA26_HUMAN	Putative PRAME family member 26	PRAMEF26	Homo sapiens (Human)	382				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
H0YKK7	reviewed	GG6LS_HUMAN	Putative golgin subfamily A member 6-like protein 19	GOLGA6L19	Homo sapiens (Human)	550							
H0YM25	reviewed	GG6LV_HUMAN	Golgin subfamily A member 6-like protein 22	GOLGA6L22	Homo sapiens (Human)	810							
H3BPF8	reviewed	GOG8S_HUMAN	Golgin subfamily A member 8S	GOLGA8S	Homo sapiens (Human)	625			Golgi organization [GO:0007030]; spindle assembly [GO:0051225]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]; spindle assembly [GO:0051225]	
H3BPM6	reviewed	MKROS_HUMAN	MKRN2 opposite strand protein (MKRN2 antisense RNA 1) (MKRN2 antisense gene protein 1)	MKRN2OS C3orf83 MKRN2-AS1	Homo sapiens (Human)	223							
H3BQJ8	reviewed	LY6L_HUMAN	Lymphocyte antigen 6L (Lymphocyte antigen 6 complex locus protein L)	LY6L	Homo sapiens (Human)	138				plasma membrane [GO:0005886]; side of membrane [GO:0098552]		plasma membrane [GO:0005886]; side of membrane [GO:0098552]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}.
H3BQL2	reviewed	GOG8T_HUMAN	Golgin subfamily A member 8T	GOLGA8T	Homo sapiens (Human)	631			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
H3BR10	reviewed	SMLR1_HUMAN	Small leucine-rich protein 1	SMLR1	Homo sapiens (Human)	107				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
H3BS89	reviewed	T178B_HUMAN	Transmembrane protein 178B	TMEM178B	Homo sapiens (Human)	294				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
H3BTG2	reviewed	TEX46_HUMAN	Testis-expressed protein 46	TEX46 C1orf234	Homo sapiens (Human)	121							
H3BU77	reviewed	CC179_HUMAN	Coiled-coil domain-containing protein 179	CCDC179	Homo sapiens (Human)	68							
H3BUK9	reviewed	POTB2_HUMAN	POTE ankyrin domain family member B2	POTEB2	Homo sapiens (Human)	544							
H3BV12	reviewed	GOG8Q_HUMAN	Golgin subfamily A member 8Q	GOLGA8Q	Homo sapiens (Human)	632			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
H7BZ55	reviewed	CRCC2_HUMAN	Ciliary rootlet coiled-coil protein 2	CROCC2	Homo sapiens (Human)	1653				centriole [GO:0005814]; centrosome [GO:0005813]		centriole [GO:0005814]; centrosome [GO:0005813]	
H7C241	reviewed	CLD34_HUMAN	Claudin-34	CLDN34	Homo sapiens (Human)	214	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250|UniProtKB:O88552}.		bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]	bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]	structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]; bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]	SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:O88552}. Cell membrane {ECO:0000250|UniProtKB:O88552}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O88552}.
H7C350	reviewed	CC188_HUMAN	Coiled-coil domain-containing protein 188	CCDC188	Homo sapiens (Human)	402				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
I3L0S3	reviewed	PYAS1_HUMAN	Putative uncharacterized protein PYCARD-AS1 (PYCARD antisense RNA 1) (PYCARD antisense gene protein 1) (PYCARD opposite strand protein)	PYCARD-AS1 C16orf98 PYCARDOS	Homo sapiens (Human)	204							
I6L899	reviewed	GOG8R_HUMAN	Golgin subfamily A member 8R	GOLGA8R	Homo sapiens (Human)	631			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
K7EIQ3	reviewed	CS082_HUMAN	Uncharacterized protein ZNF561-AS1 (ZNF561 antisense RNA 1) (ZNF561 antisense gene protein 1)	ZNF561-AS1 C19orf82	Homo sapiens (Human)	104							
L0R6Q1	reviewed	S35U4_HUMAN	SLC35A4 upstream open reading frame protein	SLC35A4	Homo sapiens (Human)	103		MISCELLANEOUS: [Isoform 2]: Product of the upstream open reading frame of this bicistronic gene. This may be the major product of the gene under normal conditions. {ECO:0000269|PubMed:25621764}.	positive regulation of translation in response to stress [GO:0032056]	membrane [GO:0016020]		membrane [GO:0016020]; positive regulation of translation in response to stress [GO:0032056]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
M0QZC1	reviewed	RN225_HUMAN	RING finger protein 225	RNF225	Homo sapiens (Human)	329			protein ubiquitination [GO:0016567]	membrane [GO:0016020]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
O00193	reviewed	SMAP_HUMAN	Small acidic protein	SMAP C11orf58	Homo sapiens (Human)	183							
O14603	reviewed	PRY_HUMAN	PTPN13-like protein, Y-linked (Testis-specific PTP-BL-related Y protein)	PRY PRY1 PTPN13LY; PRY2 PTPN13LY2; PRYP3; PRYP4	Homo sapiens (Human)	147							
O14609	reviewed	XKRY_HUMAN	Testis-specific XK-related protein, Y-linked	XKRY XKRY1	Homo sapiens (Human)	159			single fertilization [GO:0007338]	membrane [GO:0016020]		membrane [GO:0016020]; single fertilization [GO:0007338]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O14683	reviewed	P5I11_HUMAN	Tumor protein p53-inducible protein 11 (p53-induced gene 11 protein)	TP53I11 PIG11	Homo sapiens (Human)	189			negative regulation of cell population proliferation [GO:0008285]	membrane [GO:0016020]		membrane [GO:0016020]; negative regulation of cell population proliferation [GO:0008285]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
O15172	reviewed	PSPHL_HUMAN	Putative phosphoserine phosphatase-like protein (L-3-phosphoserine-phosphatase homolog)	PSPHP1 CO9 PSPHL	Homo sapiens (Human)	72				nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]		nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]	
O15428	reviewed	PINL_HUMAN	Putative PIN1-like protein (Peptidylprolyl cis-trans isomerase NIMA-interacting 1 pseudogene 1)	PIN1P1 PIN1L	Homo sapiens (Human)	100							
O15480	reviewed	MAGB3_HUMAN	Melanoma-associated antigen B3 (MAGE-B3 antigen)	MAGEB3	Homo sapiens (Human)	346			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
O43261	reviewed	LEU1_HUMAN	Leukemia-associated protein 1 (Deleted in lymphocytic leukemia 1) (HBV X-transactivated gene 6 protein) (HBV XAg-transactivated protein 6)	DLEU1 LEU1 XTP6	Homo sapiens (Human)	78	FUNCTION: May act as a tumor suppressor.						
O43304	reviewed	S14L5_HUMAN	SEC14-like protein 5	SEC14L5 KIAA0420	Homo sapiens (Human)	696				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
O60397	reviewed	COX7S_HUMAN	Putative cytochrome c oxidase subunit 7A3, mitochondrial (Cytochrome c oxidase subunit VIIa 3)	COX7A2P2 COX7A3 COX7AL2 COX7AP2	Homo sapiens (Human)	106			mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]	mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex IV [GO:0005751]		mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
O60575	reviewed	ISK4_HUMAN	Serine protease inhibitor Kazal-type 4 (Peptide PEC-60 homolog)	SPINK4	Homo sapiens (Human)	86				extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
O60688	reviewed	YPEL1_HUMAN	Protein yippee-like 1	YPEL1 FKSG3	Homo sapiens (Human)	119	FUNCTION: May play a role in epithelioid conversion of fibroblasts.			nucleus [GO:0005634]	metal ion binding [GO:0046872]	nucleus [GO:0005634]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
O60809	reviewed	PRA10_HUMAN	PRAME family member 10	PRAMEF10	Homo sapiens (Human)	474			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
O60810	reviewed	PRAM4_HUMAN	PRAME family member 4	PRAMEF4	Homo sapiens (Human)	478			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
O60813	reviewed	PRA11_HUMAN	PRAME family member 11	PRAMEF11	Homo sapiens (Human)	478			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
O75071	reviewed	EFC14_HUMAN	EF-hand calcium-binding domain-containing protein 14	EFCAB14 KIAA0494	Homo sapiens (Human)	495					calcium ion binding [GO:0005509]	calcium ion binding [GO:0005509]	
O75200	reviewed	NPIB7_HUMAN	Nuclear pore complex-interacting protein family member B7 (Nuclear pore complex-interacting protein-like 1)	NPIPB7 NPIPL1	Homo sapiens (Human)	414				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
O75264	reviewed	SIM24_HUMAN	Small integral membrane protein 24	SMIM24 C19orf77 HSPC323	Homo sapiens (Human)	130				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
O75391	reviewed	SPAG7_HUMAN	Sperm-associated antigen 7	SPAG7	Homo sapiens (Human)	227				nucleus [GO:0005634]	nucleic acid binding [GO:0003676]	nucleus [GO:0005634]; nucleic acid binding [GO:0003676]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
O76042	reviewed	ERIT1_HUMAN	Putative uncharacterized protein encoded by ERC2-IT1 (ERC2 intronic transcript protein 1) (PO42)	ERC2-IT1 C1orf1 C3orf51	Homo sapiens (Human)	136							
O95177	reviewed	GAAS1_HUMAN	Uncharacterized protein GAS8-AS1 (GAS8 antisense RNA 1) (GAS8 antisense gene protein 1)	GAS8-AS1 C16orf3	Homo sapiens (Human)	125							
O95397	reviewed	PKHA9_HUMAN	Putative protein PLEKHA9 (Pleckstrin homology domain-containing family A member 8 pseudogene 1)	PLEKHA8P1 PLEKHA9 HAW1053	Homo sapiens (Human)	391			ER to Golgi ceramide transport [GO:0035621]; intermembrane lipid transfer [GO:0120009]	cytosol [GO:0005829]	ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]	cytosol [GO:0005829]; ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ER to Golgi ceramide transport [GO:0035621]; intermembrane lipid transfer [GO:0120009]	
O95473	reviewed	SNG4_HUMAN	Synaptogyrin-4	SYNGR4	Homo sapiens (Human)	234				neuromuscular junction [GO:0031594]; synaptic vesicle membrane [GO:0030672]		neuromuscular junction [GO:0031594]; synaptic vesicle membrane [GO:0030672]	SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
O95522	reviewed	PRA12_HUMAN	PRAME family member 12	PRAMEF12	Homo sapiens (Human)	483			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
O95561	reviewed	CA105_HUMAN	Uncharacterized protein C1orf105	C1orf105	Homo sapiens (Human)	183							
O95567	reviewed	CV031_HUMAN	Uncharacterized protein C22orf31	C22orf31	Homo sapiens (Human)	290							
O95626	reviewed	AN32D_HUMAN	Acidic leucine-rich nuclear phosphoprotein 32 family member D (Phosphoprotein 32-related protein 2) (Tumorigenic protein pp32r2)	ANP32D PP32R2	Homo sapiens (Human)	131							
O95873	reviewed	CF047_HUMAN	Uncharacterized protein C6orf47 (Protein G4)	C6orf47 G4	Homo sapiens (Human)	294							
O96002	reviewed	CX001_HUMAN	Putative transmembrane protein CXorf1	CXorf1	Homo sapiens (Human)	111				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
P09565	reviewed	IG2R_HUMAN	Putative insulin-like growth factor 2-associated protein (Cell growth-inhibiting gene 44 protein) (Insulin-like growth factor II-associated protein)	GIG44 PP9974	Homo sapiens (Human)	113		MISCELLANEOUS: Encoded within 3' untranslated region of IGF2 last exon (exon 7). However, might be transcribed separately. Parallels IGF2 mRNA in its abundance. {ECO:0000269|PubMed:3167054}.					
P0C221	reviewed	CC175_HUMAN	Coiled-coil domain-containing protein 175	CCDC175 C14orf38	Homo sapiens (Human)	793							
P0C2L3	reviewed	F163B_HUMAN	Protein FAM163B	FAM163B C9orf166	Homo sapiens (Human)	166				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P0C2S0	reviewed	CTXN2_HUMAN	Cortexin-2	CTXN2	Homo sapiens (Human)	81				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P0C2W7	reviewed	CT47B_HUMAN	Cancer/testis antigen family 47 member B1 (Cancer/testis antigen 47.13) (CT47.13)	CT47B1 CT47.13	Homo sapiens (Human)	299							
P0C2Y1	reviewed	NBPF7_HUMAN	Putative neuroblastoma breakpoint family member 7	NBPF7P NBPF7	Homo sapiens (Human)	421		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P0C671	reviewed	BNIP5_HUMAN	Protein BNIP5	BNIP5 C6orf222	Homo sapiens (Human)	652							
P0C672	reviewed	TSN19_HUMAN	Tetraspanin-19 (Tspan-19)	TSPAN19	Homo sapiens (Human)	248				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P0C6C1	reviewed	AN34C_HUMAN	Ankyrin repeat domain-containing protein 34C	ANKRD34C	Homo sapiens (Human)	535			piRNA processing [GO:0034587]	pi-body [GO:0071546]		pi-body [GO:0071546]; piRNA processing [GO:0034587]	
P0C6P0	reviewed	BCL8_HUMAN	Putative protein BCL8 (Neurobeachin pseudogene 1)	NBEAP1 BCL8 BCL8A	Homo sapiens (Human)	100							
P0C7I6	reviewed	CC159_HUMAN	Coiled-coil domain-containing protein 159	CCDC159	Homo sapiens (Human)	297							
P0C7L1	reviewed	ISK8_HUMAN	Serine protease inhibitor Kazal-type 8	SPINK8	Homo sapiens (Human)	97	FUNCTION: Probable serine protease inhibitor. {ECO:0000250}.			extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P0C7M6	reviewed	IQCF3_HUMAN	IQ domain-containing protein F3	IQCF3	Homo sapiens (Human)	154					calmodulin binding [GO:0005516]	calmodulin binding [GO:0005516]	
P0C7M8	reviewed	CLC2L_HUMAN	C-type lectin domain family 2 member L	CLEC2L	Homo sapiens (Human)	214				membrane [GO:0016020]	carbohydrate binding [GO:0030246]	membrane [GO:0016020]; carbohydrate binding [GO:0030246]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P0C7N4	reviewed	T191B_HUMAN	Transmembrane protein 191B	TMEM191B	Homo sapiens (Human)	346				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
P0C7N8	reviewed	OR9G9_HUMAN	Olfactory receptor 9G9	OR9G9	Homo sapiens (Human)	305	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
P0C7P2	reviewed	RFL3S_HUMAN	Putative protein RFPL3S (RFPL3 antisense RNA 1) (RFPL3 antisense gene protein 1) (Ret finger protein-like 3 antisense gene protein)	RFPL3S RFPL3-AS1	Homo sapiens (Human)	107		MISCELLANEOUS: The gene encoding RFPL3S is located on the opposite strand of the gene encoding RFPL3. Its transcription may play a role in RFPL3 transcription regulation.					
P0C7Q5	reviewed	S35G4_HUMAN	Putative solute carrier family 35 member G4 (Acyl-malonyl-condensing enzyme 1-like protein 1)	SLC35G4 AMAC1L1 SLC35G4P	Homo sapiens (Human)	338				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P0C7T7	reviewed	FMAS1_HUMAN	Putative uncharacterized protein FRMD6-AS1 (FRMD6 antisense RNA 1) (FRMD6 antisense gene protein 1)	FRMD6-AS1 C14orf82	Homo sapiens (Human)	363							
P0C7T8	reviewed	TM253_HUMAN	Transmembrane protein 253	TMEM253 C14orf176 C14orf95	Homo sapiens (Human)	217				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P0C7V0	reviewed	CF217_HUMAN	Putative uncharacterized protein encoded by LINC00271 (AHI1 divergent transcript)	AHI1-DT C6orf217 LINC00271 NCRNA00271	Homo sapiens (Human)	271							
P0C7V4	reviewed	F90AF_HUMAN	Putative protein FAM90A15P	FAM90A15P FAM90A15	Homo sapiens (Human)	464							
P0C7V6	reviewed	SP202_HUMAN	Putative transcription factor SPT20 homolog-like 2	SUPT20HL2 FAM48B2	Homo sapiens (Human)	817			regulation of transcription by RNA polymerase II [GO:0006357]	extracellular space [GO:0005615]; SAGA complex [GO:0000124]	transcription coregulator activity [GO:0003712]	extracellular space [GO:0005615]; SAGA complex [GO:0000124]; transcription coregulator activity [GO:0003712]; regulation of transcription by RNA polymerase II [GO:0006357]	
P0C7V8	reviewed	DC8L2_HUMAN	DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C)	DCAF8L2 WDR42C	Homo sapiens (Human)	631				Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; nucleus [GO:0005634]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	
P0C7V9	reviewed	ME15P_HUMAN	Putative methyltransferase-like protein 15P1 (EC 2.1.1.-) (Methyltransferase 5 domain-containing protein 2) (Methyltransferase-like protein 15 pseudogene 1)	METTL15P1 METT5D2	Homo sapiens (Human)	234	FUNCTION: Probable S-adenosyl-L-methionine-dependent methyltransferase. {ECO:0000250}.		rRNA base methylation [GO:0070475]		rRNA (cytosine-N4-)-methyltransferase activity [GO:0071424]	rRNA (cytosine-N4-)-methyltransferase activity [GO:0071424]; rRNA base methylation [GO:0070475]	
P0C7W0	reviewed	PRR29_HUMAN	Proline-rich protein 29	PRR29 C17orf72	Homo sapiens (Human)	189							
P0C7W8	reviewed	F90AD_HUMAN	Putative protein FAM90A13P	FAM90A13P FAM90A13	Homo sapiens (Human)	464							
P0C7W9	reviewed	F90AE_HUMAN	Putative protein FAM90A14	FAM90A14 FAM90A14P	Homo sapiens (Human)	464							
P0C7X0	reviewed	F90AO_HUMAN	Putative protein FAM90A24P	FAM90A24P FAM90A24	Homo sapiens (Human)	464							
P0C7X3	reviewed	CCYL3_HUMAN	Putative cyclin-Y-like protein 3	CCNYL3	Homo sapiens (Human)	344			regulation of canonical Wnt signaling pathway [GO:0060828]	plasma membrane [GO:0005886]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]	plasma membrane [GO:0005886]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; regulation of canonical Wnt signaling pathway [GO:0060828]	
P0C7X4	reviewed	FHL19_HUMAN	Putative ferritin heavy polypeptide-like 19 (Ferritin heavy polypeptide 1 pseudogene 19)	FTH1P19 FTHL19	Homo sapiens (Human)	201			intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826]	cytoplasm [GO:0005737]	ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]	cytoplasm [GO:0005737]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826]	
P0C841	reviewed	FA66E_HUMAN	Putative protein FAM66E	FAM66E	Homo sapiens (Human)	47							
P0C853	reviewed	BAAS2_HUMAN	Putative uncharacterized protein BAALC-AS2 (BAALC antisense RNA 2) (BAALC antisense gene protein 2) (BAALC opposite strand protein)	BAALC-AS2 BAALCOS C8orf56	Homo sapiens (Human)	105							
P0C854	reviewed	CECR9_HUMAN	Putative cat eye syndrome critical region protein 9	CECR9	Homo sapiens (Human)	216		MISCELLANEOUS: Candidate gene for the Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. Duplication usually takes in the form of a surpernumerary bisatellited isodicentric chromosome, resulting in four copies of the region (represents an inv dup(22)(q11)). CES is characterized clinically by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development.		extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P0C864	reviewed	DANCR_HUMAN	Putative uncharacterized protein DANCR (Anti-differentiation ncRNA protein) (Differentiation antagonizing non-protein coding RNA) (Small nucleolar RNA host gene protein 13)	DANCR ANCR KIAA0114 SNHG13	Homo sapiens (Human)	163							
P0C866	reviewed	F91A2_HUMAN	Putative uncharacterized protein encoded by LINC00869	LINC00869 FAM91A2 KIAA0493	Homo sapiens (Human)	280							
P0C874	reviewed	S31D3_HUMAN	Spermatogenesis-associated protein 31D3 (Protein FAM75D3)	SPATA31D3 FAM75D3	Homo sapiens (Human)	917	FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P0C881	reviewed	R10B1_HUMAN	Radial spoke head 10 homolog B	RSPH10B	Homo sapiens (Human)	870	FUNCTION: May function as part of the axonemal radial spoke complex 3 (RS3). Radial spoke complexes are important for ciliary motility. {ECO:0000250|UniProtKB:E9PYQ0}.			cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]		cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:E9PYQ0}.
P0CAT3	reviewed	TLXNB_HUMAN	Putative TLX1 neighbor protein (TLX1 divergent gene protein)	TLX1NB TDI	Homo sapiens (Human)	122		MISCELLANEOUS: Oriented in a head-to-head manner with TLX1/HOX11. Both genes share the same promoter with robust bidirectional activity.					
P0CB48	reviewed	UBFL6_HUMAN	Putative upstream-binding factor 1-like protein 6	UBTFL6	Homo sapiens (Human)	400			positive regulation of transcription by RNA polymerase I [GO:0045943]; transcription by RNA polymerase I [GO:0006360]	nucleus [GO:0005634]	RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]	nucleus [GO:0005634]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; positive regulation of transcription by RNA polymerase I [GO:0045943]; transcription by RNA polymerase I [GO:0006360]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
P0CE71	reviewed	OCM2_HUMAN	Putative oncomodulin-2	OCM2 OCMN	Homo sapiens (Human)	109				cytoplasm [GO:0005737]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]	
P0CF75	reviewed	EBLN1_HUMAN	Endogenous Bornavirus-like nucleoprotein 1 (Endogenous Borna-like N element-1) (EBLN-1)	EBLN1	Homo sapiens (Human)	366	FUNCTION: May act as an RNA-binding protein. Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity). {ECO:0000250}.	MISCELLANEOUS: Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-1 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.					
P0CG23	reviewed	ZN853_HUMAN	Zinc finger protein 853	ZNF853	Homo sapiens (Human)	659			regulation of transcription by RNA polymerase II [GO:0006357]		DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	
P0CG24	reviewed	ZN883_HUMAN	Zinc finger protein 883	ZNF883	Homo sapiens (Human)	379	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P0CG32	reviewed	ZCC18_HUMAN	Zinc finger CCHC domain-containing protein 18	ZCCHC18	Homo sapiens (Human)	403				nucleus [GO:0005634]	metal ion binding [GO:0046872]	nucleus [GO:0005634]; metal ion binding [GO:0046872]	
P0CG33	reviewed	GOG6D_HUMAN	Golgin subfamily A member 6D	GOLGA6D	Homo sapiens (Human)	693			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
P0CG41	reviewed	CTGE8_HUMAN	cTAGE family member 8 (Protein cTAGE-8)	CTAGE8	Homo sapiens (Human)	777			endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P0CI00	reviewed	Z705B_HUMAN	Putative zinc finger protein 705B	ZNF705B	Homo sapiens (Human)	300	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P0CI01	reviewed	SPDE6_HUMAN	Speedy protein E6	SPDYE6	Homo sapiens (Human)	402					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
P0CJ68	reviewed	HMN1_HUMAN	Humanin-like 1 (HN1) (MT-RNR2-like protein 1)	MTRNR2L1	Homo sapiens (Human)	24	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.		negative regulation of execution phase of apoptosis [GO:1900118]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	receptor antagonist activity [GO:0048019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; negative regulation of execution phase of apoptosis [GO:1900118]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ69	reviewed	HMN2_HUMAN	Humanin-like 2 (HN2) (MT-RNR2-like protein 2)	MTRNR2L2	Homo sapiens (Human)	28	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.		negative regulation of execution phase of apoptosis [GO:1900118]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	receptor antagonist activity [GO:0048019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; negative regulation of execution phase of apoptosis [GO:1900118]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ70	reviewed	HMN3_HUMAN	Humanin-like 3 (HN3) (MT-RNR2-like protein 3)	MTRNR2L3	Homo sapiens (Human)	24	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.		negative regulation of execution phase of apoptosis [GO:1900118]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	receptor antagonist activity [GO:0048019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; negative regulation of execution phase of apoptosis [GO:1900118]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ71	reviewed	HMN4_HUMAN	Humanin-like 4 (HN4) (MT-RNR2-like protein 4)	MTRNR2L4	Homo sapiens (Human)	28	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.		negative regulation of execution phase of apoptosis [GO:1900118]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	receptor antagonist activity [GO:0048019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; negative regulation of execution phase of apoptosis [GO:1900118]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ73	reviewed	HMN6_HUMAN	Humanin-like 6 (HN6) (MT-RNR2-like protein 6)	MTRNR2L6	Homo sapiens (Human)	24	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.		negative regulation of execution phase of apoptosis [GO:1900118]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	receptor antagonist activity [GO:0048019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; negative regulation of execution phase of apoptosis [GO:1900118]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ74	reviewed	HMN7_HUMAN	Humanin-like 7 (HN7) (MT-RNR2-like protein 7)	MTRNR2L7	Homo sapiens (Human)	24	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.		negative regulation of execution phase of apoptosis [GO:1900118]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	receptor antagonist activity [GO:0048019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; negative regulation of execution phase of apoptosis [GO:1900118]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ75	reviewed	HMN8_HUMAN	Humanin-like 8 (HN8) (MT-RNR2-like protein 8)	MTRNR2L8	Homo sapiens (Human)	24	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.		negative regulation of execution phase of apoptosis [GO:1900118]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	receptor antagonist activity [GO:0048019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; negative regulation of execution phase of apoptosis [GO:1900118]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ76	reviewed	HMN9_HUMAN	Humanin-like 9 (HN9) (MT-RNR2-like protein 9)	MTRNR2L9	Homo sapiens (Human)	24	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.		negative regulation of execution phase of apoptosis [GO:1900118]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	receptor antagonist activity [GO:0048019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; negative regulation of execution phase of apoptosis [GO:1900118]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ77	reviewed	HMN10_HUMAN	Humanin-like 10 (HN10) (MT-RNR2-like protein 10)	MTRNR2L10	Homo sapiens (Human)	24	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.		negative regulation of execution phase of apoptosis [GO:1900118]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	receptor antagonist activity [GO:0048019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; negative regulation of execution phase of apoptosis [GO:1900118]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ85	reviewed	DU4L2_HUMAN	Double homeobox protein 4-like protein 2	DUX4L2	Homo sapiens (Human)	424	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
P0CJ86	reviewed	DU4L3_HUMAN	Double homeobox protein 4-like protein 3	DUX4L3	Homo sapiens (Human)	424	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
P0CJ87	reviewed	DU4L4_HUMAN	Double homeobox protein 4-like protein 4	DUX4L4	Homo sapiens (Human)	422	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
P0CJ88	reviewed	DU4L5_HUMAN	Double homeobox protein 4-like protein 5	DUX4L5	Homo sapiens (Human)	424	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
P0CJ89	reviewed	DU4L6_HUMAN	Double homeobox protein 4-like protein 6	DUX4L6	Homo sapiens (Human)	424	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
P0CJ90	reviewed	DU4L7_HUMAN	Double homeobox protein 4-like protein 7	DUX4L7	Homo sapiens (Human)	424	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
P0CJ92	reviewed	GOG8H_HUMAN	Golgin subfamily A member 8H	GOLGA8H	Homo sapiens (Human)	632			Golgi organization [GO:0007030]	cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]		cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi organization [GO:0007030]	
P0CL80	reviewed	GG12F_HUMAN	G antigen 12F (GAGE-12F)	GAGE12F	Homo sapiens (Human)	117		MISCELLANEOUS: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
P0CL81	reviewed	GG12G_HUMAN	G antigen 12G (GAGE-12G)	GAGE12G	Homo sapiens (Human)	117		MISCELLANEOUS: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
P0CL83	reviewed	ST3L1_HUMAN	Putative STAG3-like protein 1 (Stromal antigen 3-like protein 1)	STAG3L1	Homo sapiens (Human)	205				nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750}.
P0CL84	reviewed	ST3L2_HUMAN	Putative STAG3-like protein 2 (Stromal antigen 3-like protein 2)	STAG3L2	Homo sapiens (Human)	134				nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750}.
P0CL85	reviewed	ST3L3_HUMAN	STAG3-like protein 3 (Stromal antigen 3-like protein 3)	STAG3L3	Homo sapiens (Human)	134				nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750}.
P0CW19	reviewed	LIMS3_HUMAN	LIM and senescent cell antigen-like-containing domain protein 3 (Particularly interesting new Cys-His protein 3) (PINCH-3)	LIMS3 PINCH3	Homo sapiens (Human)	117				cytoplasm [GO:0005737]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P0CW21	reviewed	SPGOS_HUMAN	Putative uncharacterized protein SPART-AS1 (SPART antisense RNA 1) (SPG20 antisense RNA 1) (SPG20 opposite strand transcript protein)	SPART-AS1 C13orf43 SPG20-AS1 SPG20OS	Homo sapiens (Human)	52							
P0CW24	reviewed	PNM6A_HUMAN	Paraneoplastic antigen-like protein 6A	PNMA6A PNMA6C	Homo sapiens (Human)	399							
P0CW27	reviewed	CC166_HUMAN	Coiled-coil domain-containing protein 166	CCDC166	Homo sapiens (Human)	439							
P0DI80	reviewed	SMIM6_HUMAN	Small integral membrane protein 6	SMIM6 C17orf110	Homo sapiens (Human)	62				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P0DJ93	reviewed	SIM13_HUMAN	Small integral membrane protein 13	SMIM13 C6orf228	Homo sapiens (Human)	91				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P0DJG4	reviewed	SMA2L_HUMAN	Sperm microtubule associated protein 2-like (Testicular haploid expressed gene protein-like) (Theg spermatid-like protein)	SPMAP2L THEGL	Homo sapiens (Human)	465							
P0DJH9	reviewed	RD3L_HUMAN	Protein RD3-like (Retinal degeneration protein 3-like)	RD3L	Homo sapiens (Human)	198							
P0DJR0	reviewed	GIMD1_HUMAN	GTPase IMAP family member GIMD1 (GIMAP family P-loop NTPase domain-containing protein 1)	GIMD1	Homo sapiens (Human)	217					GTP binding [GO:0005525]	GTP binding [GO:0005525]	
P0DKB5	reviewed	TPBGL_HUMAN	Trophoblast glycoprotein-like	TPBGL	Homo sapiens (Human)	382			negative regulation of canonical Wnt signaling pathway [GO:0090090]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; negative regulation of canonical Wnt signaling pathway [GO:0090090]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
P0DKX0	reviewed	ZN728_HUMAN	Zinc finger protein 728	ZNF728	Homo sapiens (Human)	622			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	
P0DKX4	reviewed	SIM18_HUMAN	Small integral membrane protein 18	SMIM18	Homo sapiens (Human)	95				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P0DL12	reviewed	SIM17_HUMAN	Small integral membrane protein 17	SMIM17	Homo sapiens (Human)	118				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P0DMB1	reviewed	P23D2_HUMAN	Proline-rich protein 23D2	PRR23D2	Homo sapiens (Human)	279							
P0DMB2	reviewed	CH088_HUMAN	Uncharacterized protein C8orf88	C8orf88	Homo sapiens (Human)	117			negative regulation of translational initiation [GO:0045947]	cytoplasm [GO:0005737]	eukaryotic initiation factor 4E binding [GO:0008190]	cytoplasm [GO:0005737]; eukaryotic initiation factor 4E binding [GO:0008190]; negative regulation of translational initiation [GO:0045947]	
P0DMP1	reviewed	HMN12_HUMAN	Humanin-like 12 (HN12) (MT-RNR2-like protein 12)	MTRNR2L12	Homo sapiens (Human)	24	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.		negative regulation of execution phase of apoptosis [GO:1900118]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	receptor antagonist activity [GO:0048019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; negative regulation of execution phase of apoptosis [GO:1900118]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
P0DMQ5	reviewed	INAM2_HUMAN	Putative transmembrane protein INAFM2 (InaF-motif-containing protein 2) (Osteogenesis up-regulated transcript 1)	INAFM2 LINC00984 OGU1	Homo sapiens (Human)	153				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
P0DMR1	reviewed	HNRC4_HUMAN	Heterogeneous nuclear ribonucleoprotein C-like 4	HNRNPCL4	Homo sapiens (Human)	293				nucleus [GO:0005634]	RNA binding [GO:0003723]	nucleus [GO:0005634]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P07910}.
P0DMR2	reviewed	SG1C2_HUMAN	Secretoglobin family 1C member 2	SCGB1C2	Homo sapiens (Human)	95				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P11684}.
P0DMR3	reviewed	AT8OS_HUMAN	Putative protein ATXN8OS (ATXN8 opposite strand) (Spinocerebellar ataxia 8) (kelch-like 1 antisense)	ATXN8OS KLHL1AS SCA8	Homo sapiens (Human)	200				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24040107}.
P0DMU7	reviewed	CT456_HUMAN	Cancer/testis antigen family 45 member A6 (Cancer/testis antigen 45-6) (Cancer/testis antigen 45A6)	CT45A6 CT45-6	Homo sapiens (Human)	189							
P0DMU8	reviewed	CT455_HUMAN	Cancer/testis antigen family 45 member A5 (Cancer/testis antigen 45-5) (Cancer/testis antigen 45A5)	CT45A5 CT45-5	Homo sapiens (Human)	189							
P0DMU9	reviewed	CT45A_HUMAN	Cancer/testis antigen family 45 member A10 (Cancer/testis antigen 45A10)	CT45A10	Homo sapiens (Human)	189					identical protein binding [GO:0042802]	identical protein binding [GO:0042802]	
P0DMV0	reviewed	CT457_HUMAN	Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7)	CT45A7	Homo sapiens (Human)	189							
P0DN25	reviewed	C1C1L_HUMAN	C1GALT1-specific chaperone 1-like protein	C1GALT1C1L	Homo sapiens (Human)	315				membrane [GO:0016020]	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263]	membrane [GO:0016020]; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
P0DN26	reviewed	PAL4F_HUMAN	Peptidyl-prolyl cis-trans isomerase A-like 4F (PPIase A-like 4F) (EC 5.2.1.8)	PPIAL4F	Homo sapiens (Human)	164	FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.	MISCELLANEOUS: It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1. {ECO:0000305}.	protein folding [GO:0006457]	cytoplasm [GO:0005737]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62937}.
P0DO92	reviewed	ENOL_HUMAN	Putative protein T-ENOL (CDIP transferase opposite strand, pseudogene) (CDIPT antisense RNA 1)	CDIPTOSP CDIPT-AS1 T-ENOL	Homo sapiens (Human)	83							
P0DOY5	reviewed	HD101_HUMAN	Immunoglobulin heavy diversity 1-1	IGHD1-1	Homo sapiens (Human)	5	FUNCTION: D region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.		adaptive immune response [GO:0002250]	extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DP42	reviewed	T225B_HUMAN	Transmembrane protein 225B	TMEM225B	Homo sapiens (Human)	221				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
P0DP75	reviewed	M14OS_HUMAN	Putative uncharacterized protein MED14OS (MED14 antisense gene protein 1) (MED14 opposite strand protein)	MED14OS MED14-AS1	Homo sapiens (Human)	135							
P0DPA2	reviewed	VSIG8_HUMAN	V-set and immunoglobulin domain-containing protein 8	VSIG8 C1orf204	Homo sapiens (Human)	414				membrane [GO:0016020]	RNA binding [GO:0003723]	membrane [GO:0016020]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
P0DPA3	reviewed	SNH28_HUMAN	Putative uncharacterized protein SNHG28 (Small nucleolar RNA host gene 2) (VSIG8 overlapping transcript protein) (VSIG8-OT1)	SNHG28 C1orf204	Homo sapiens (Human)	235					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
P0DPD5	reviewed	ZN723_HUMAN	Zinc finger protein 723	ZNF723	Homo sapiens (Human)	513	FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
P0DPE3	reviewed	TMDD1_HUMAN	Transmembrane and death domain protein 1	TMDD1 C12orf81	Homo sapiens (Human)	317			signal transduction [GO:0007165]	membrane [GO:0016020]		membrane [GO:0016020]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
P0DPF2	reviewed	NBPFK_HUMAN	Neuroblastoma breakpoint family member 20	NBPF20	Homo sapiens (Human)	5207		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
P0DPH9	reviewed	CX05B_HUMAN	Uncharacterized protein CXorf51B	CXorf51B	Homo sapiens (Human)	108							
P0DPI3	reviewed	CENL2_HUMAN	Centromere protein V-like protein 2 (Centromere protein V pseudogene 2)	CENPVL2 CENPVP2	Homo sapiens (Human)	272					carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872]	carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872]	
P0DPI4	reviewed	TDB01_HUMAN	T cell receptor beta diversity 1	TRBD1	Homo sapiens (Human)	4	FUNCTION: D region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
P0DPR3	reviewed	TRDD1_HUMAN	T cell receptor delta diversity 1	TRDD1	Homo sapiens (Human)	2	FUNCTION: D region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089, ECO:0000303|PubMed:28920588}.		adaptive immune response [GO:0002250]	T cell receptor complex [GO:0042101]		T cell receptor complex [GO:0042101]; adaptive immune response [GO:0002250]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
P0DQW0	reviewed	ZC11C_HUMAN	Zinc finger CCCH domain-containing protein 11C	ZC3H11C	Homo sapiens (Human)	805					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
P0DSN6	reviewed	T2R33_HUMAN	Putative taste receptor type 2 member 33 (T2R33) (hGR33)	TAS2R33	Homo sapiens (Human)	309	FUNCTION: Putative taste receptor which may play a role in the perception of bitterness. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
P0DSO1	reviewed	F246C_HUMAN	Protein FAM246C	FAM246C	Homo sapiens (Human)	240							
P0DSO3	reviewed	GAGE4_HUMAN	G antigen 4 (Cancer/testis antigen 4.4) (CT4.4)	GAGE4	Homo sapiens (Human)	117	FUNCTION: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:7544395}.	MISCELLANEOUS: This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells. {ECO:0000269|PubMed:10397259, ECO:0000269|PubMed:7544395}.					
P0DTA3	reviewed	SPD11_HUMAN	Putative speedy protein E11	SPDYE11	Homo sapiens (Human)	265	FUNCTION: Acts as a modulator of the nicotinic acetylcholine receptor alpha-7 (CHRNA7) activity. {ECO:0000269|PubMed:27789755}.				acetylcholine receptor regulator activity [GO:0030548]; protein kinase binding [GO:0019901]	acetylcholine receptor regulator activity [GO:0030548]; protein kinase binding [GO:0019901]	
P0DTE0	reviewed	T2R36_HUMAN	Putative taste receptor type 2 member 36 (T2R36) (hGR36)	TAS2R36	Homo sapiens (Human)	309	FUNCTION: Putative taste receptor which may play a role in the perception of bitterness. {ECO:0000305}.		detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	plasma membrane [GO:0005886]	bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
P0DTF9	reviewed	PTIP2_HUMAN	PTTG1IP family member 2	PTTG1IP2	Homo sapiens (Human)	154				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
P0DTL4	reviewed	LY6S_HUMAN	Lymphocyte antigen 6S	LY6S	Homo sapiens (Human)	134				plasma membrane [GO:0005886]; side of membrane [GO:0098552]		plasma membrane [GO:0005886]; side of membrane [GO:0098552]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}.
P0DTW1	reviewed	GAGE1_HUMAN	G antigen 1 (GAGE-1) (Antigen MZ2-F) (Cancer/testis antigen 4.1) (CT4.1)	GAGE1	Homo sapiens (Human)	117	FUNCTION: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:7544395}.	MISCELLANEOUS: This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells. {ECO:0000269|PubMed:10397259, ECO:0000269|PubMed:7544395}.					
P0DUD1	reviewed	SPD8_HUMAN	Putative speedy protein E8	SPDYE8	Homo sapiens (Human)	265					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
P0DUD2	reviewed	SPD17_HUMAN	Putative speedy protein E17	SPDYE17	Homo sapiens (Human)	265					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
P0DUD3	reviewed	SPD14_HUMAN	Putative speedy protein E14	SPDYE14	Homo sapiens (Human)	265					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
P0DUD4	reviewed	SPD15_HUMAN	Putative speedy protein E15	SPDYE15	Homo sapiens (Human)	265					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
P0DUQ1	reviewed	PRA15_HUMAN	PRAME family member 15	PRAMEF15	Homo sapiens (Human)	478			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
P0DUX0	reviewed	SPD10_HUMAN	Speedy protein E10	SPDYE10 SPDYE10P	Homo sapiens (Human)	265					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
P0DUX1	reviewed	SPD12_HUMAN	Speedy protein E12	SPDYE12 SPDYE12P	Homo sapiens (Human)	265					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
P0DV73	reviewed	F90AG_HUMAN	Protein FAM90A16	FAM90A16 FAM90A16P	Homo sapiens (Human)	464							
P0DV74	reviewed	F90AH_HUMAN	Protein FAM90A17	FAM90A17 FAM90A17P	Homo sapiens (Human)	464							
P0DV75	reviewed	F90AI_HUMAN	Protein FAM90A18	FAM90A18 FAM90A18P	Homo sapiens (Human)	464							
P0DV76	reviewed	F90AJ_HUMAN	Protein FAM90A19	FAM90A19 FAM90A19P	Homo sapiens (Human)	464							
P0DV79	reviewed	SPD18_HUMAN	Speedy protein E18	SPDYE18	Homo sapiens (Human)	352					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
P0DW11	reviewed	TFKL6_HUMAN	TATA-box-binding protein-associated factor 11-like protein 6	TAF11L6	Homo sapiens (Human)	198			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
P0DW12	reviewed	TFKL7_HUMAN	TATA-box-binding protein-associated factor 11-like protein 7	TAF11L7	Homo sapiens (Human)	198			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
P0DW13	reviewed	TFKL8_HUMAN	TATA-box-binding protein-associated factor 11-like protein 8	TAF11L8	Homo sapiens (Human)	198			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
P0DW14	reviewed	TFKLJ_HUMAN	TATA-box-binding protein-associated factor 11-like protein 10	TAF11L10	Homo sapiens (Human)	198			RNA polymerase II preinitiation complex assembly [GO:0051123]	transcription factor TFIID complex [GO:0005669]	protein heterodimerization activity [GO:0046982]	transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; RNA polymerase II preinitiation complex assembly [GO:0051123]	
P0DW85	reviewed	H2BN1_HUMAN	Histone H2A.N (H2B.N) (H2B.N variant histone 1)	H2BN1	Homo sapiens (Human)	118	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000305}.			nucleosome [GO:0000786]; nucleus [GO:0005634]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
P0DX00	reviewed	GG6LX_HUMAN	Golgin subfamily A member 6-like protein 24	GOLGA6L24	Homo sapiens (Human)	832							
P0DX01	reviewed	GG6LY_HUMAN	Golgin subfamily A member 6-like protein 25	GOLGA6L25	Homo sapiens (Human)	826							
P0DX02	reviewed	GG6LZ_HUMAN	Golgin subfamily A member 6-like protein 26	GOLGA6L26	Homo sapiens (Human)	649							
P0DX04	reviewed	TB15C_HUMAN	Thymosin beta-15C	TMSB15C	Homo sapiens (Human)	45	FUNCTION: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G-actin) and therefore inhibits actin polymerization. {ECO:0000250|UniProtKB:P62328}.		actin filament organization [GO:0007015]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	actin monomer binding [GO:0003785]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; actin monomer binding [GO:0003785]; actin filament organization [GO:0007015]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P62328}.
P49223	reviewed	SPIT3_HUMAN	Kunitz-type protease inhibitor 3 (HKIB9)	SPINT3	Homo sapiens (Human)	89				extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P56555	reviewed	DSCR4_HUMAN	Down syndrome critical region protein 4 (Down syndrome critical region protein B)	DSCR4 DCRB DSCRB	Homo sapiens (Human)	118							
P58417	reviewed	NXPH1_HUMAN	Neurexophilin-1	NXPH1 NPH1 Nbla00697	Homo sapiens (Human)	271	FUNCTION: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. {ECO:0000305}.			extracellular region [GO:0005576]	signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; signaling receptor binding [GO:0005102]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
P58505	reviewed	CU058_HUMAN	Uncharacterized protein C21orf58	C21orf58	Homo sapiens (Human)	322							
P58512	reviewed	CU067_HUMAN	Uncharacterized protein encoded by LINC01547	LINC01547 C21orf67 C21orf69	Homo sapiens (Human)	204				endoplasmic reticulum [GO:0005783]		endoplasmic reticulum [GO:0005783]	
P58550	reviewed	FXYD8_HUMAN	Putative FXYD domain-containing ion transport regulator 8	FXYD6P3 FXYD8	Homo sapiens (Human)	94			monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269]	membrane [GO:0016020]	sodium channel regulator activity [GO:0017080]	membrane [GO:0016020]; sodium channel regulator activity [GO:0017080]; monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
P59036	reviewed	CU082_HUMAN	Putative uncharacterized protein encoded by LINC00310	LINC00310 C21orf82 NCRNA00310	Homo sapiens (Human)	64							
P59037	reviewed	CU084_HUMAN	Putative uncharacterized protein encoded by LINC00313	LINC00313 C21orf84 NCRNA00313	Homo sapiens (Human)	77							
P59051	reviewed	BRAS2_HUMAN	Putative uncharacterized protein encoded by BRWD1-AS2 (ATP1A1 antisense RNA 1) (ATP1A1 antisense gene protein 1) (BRWD1 intronic transcript 2)	BRWD1-AS2 BRWD1-IT2 C21orf87 NCRNA00257	Homo sapiens (Human)	145							
P59052	reviewed	B3AS1_HUMAN	Putative uncharacterized protein B3GALT5-AS1 (B3GALT5 antisense RNA 1) (B3GALT5 antisense gene protein 1)	B3GALT5-AS1 C21orf88	Homo sapiens (Human)	145							
P59090	reviewed	TSAS2_HUMAN	Putative uncharacterized protein TSPEAR-AS2 (TSPEAR antisense RNA 2) (TSPEAR antisense gene protein 2)	TSPEAR-AS2 C21orf90	Homo sapiens (Human)	65							
P59091	reviewed	CU093_HUMAN	Putative uncharacterized protein encoded by LINC00315	LINC00315 C21orf93 NCRNA00315	Homo sapiens (Human)	139							
P59095	reviewed	STAR6_HUMAN	StAR-related lipid transfer protein 6 (START domain-containing protein 6) (StARD6)	STARD6	Homo sapiens (Human)	220	FUNCTION: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity). {ECO:0000250}.		lipid transport [GO:0006869]		lipid binding [GO:0008289]	lipid binding [GO:0008289]; lipid transport [GO:0006869]	
P59646	reviewed	FXYD4_HUMAN	FXYD domain-containing ion transport regulator 4	FXYD4 UNQ526/PRO1069	Homo sapiens (Human)	89			regulation of monoatomic ion transport [GO:0043269]	plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]	potassium channel activity [GO:0005267]; sodium channel regulator activity [GO:0017080]	plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; potassium channel activity [GO:0005267]; sodium channel regulator activity [GO:0017080]; regulation of monoatomic ion transport [GO:0043269]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
P60002	reviewed	ELOF1_HUMAN	Transcription elongation factor 1 homolog	ELOF1	Homo sapiens (Human)	83	FUNCTION: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. {ECO:0000250}.		transcription elongation by RNA polymerase II [GO:0006368]	transcription elongation factor complex [GO:0008023]	metal ion binding [GO:0046872]; RNA polymerase II complex binding [GO:0000993]	transcription elongation factor complex [GO:0008023]; metal ion binding [GO:0046872]; RNA polymerase II complex binding [GO:0000993]; transcription elongation by RNA polymerase II [GO:0006368]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
P60606	reviewed	CTXN1_HUMAN	Cortexin-1	CTXN1 CTXN	Homo sapiens (Human)	82	FUNCTION: May mediate extracellular or intracellular signaling of cortical neurons during forebrain development. {ECO:0000250}.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
P61568	reviewed	ENK11_HUMAN	Putative endogenous retrovirus group K member 11-1 Env polyprotein (Envelope polyprotein) (HERV-K_1p13.3 provirus ancestral Env polyprotein) [Includes: Truncated surface protein (SU)]	ERVK11-1	Homo sapiens (Human)	191	FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity). {ECO:0000250}.	MISCELLANEOUS: Intergenic, closest flanking genes being GSTM1 and GSTM5.					SUBCELLULAR LOCATION: Virion {ECO:0000250}.
P61571	reviewed	REC21_HUMAN	Endogenous retrovirus group K member 21 Rec protein (HERV-K_12q14.1 provirus Rec protein)	ERVK-21	Homo sapiens (Human)	104	FUNCTION: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity). {ECO:0000250}.	MISCELLANEOUS: Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex.; MISCELLANEOUS: ERVK-21 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HMLM-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3' part of the proviral genome.	mRNA transport [GO:0051028]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; mRNA transport [GO:0051028]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity). {ECO:0000250}.
P61572	reviewed	REC19_HUMAN	Endogenous retrovirus group K member 19 Rec protein (HERV-K(C19) Rec protein) (HERV-K_19q11 provirus Rec protein)	ERVK-19	Homo sapiens (Human)	105	FUNCTION: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity). {ECO:0000250}.	MISCELLANEOUS: Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex.; MISCELLANEOUS: ERVK-19 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HMLM-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3' part of the proviral genome.	mRNA transport [GO:0051028]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; mRNA transport [GO:0051028]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity). {ECO:0000250}.
P61573	reviewed	REC9_HUMAN	Endogenous retrovirus group K member 9 Rec protein (HERV-K(C6) Rec protein) (HERV-K109 Rec protein) (HERV-K_6q14.1 provirus Rec protein)	ERVK-9	Homo sapiens (Human)	105	FUNCTION: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity). {ECO:0000250}.	MISCELLANEOUS: Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex.; MISCELLANEOUS: This Rec protein is encoded by a human specific provirus.; MISCELLANEOUS: ERVK-9 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HMLM-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3' part of the proviral genome.	mRNA transport [GO:0051028]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; mRNA transport [GO:0051028]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity). {ECO:0000250}.
P61574	reviewed	RE113_HUMAN	Endogenous retrovirus group K member 113 Rec protein (HERV-K113 Rec protein) (HERV-K_19p13.11 provirus Rec protein)	HERVK_113	Homo sapiens (Human)	105	FUNCTION: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity). {ECO:0000250}.	MISCELLANEOUS: Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex.; MISCELLANEOUS: Insertional polymorphism. Provirus present in 29% of tested individuals.; MISCELLANEOUS: Has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HMLM-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3' part of the proviral genome.	mRNA transport [GO:0051028]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; mRNA transport [GO:0051028]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity). {ECO:0000250}.
P61575	reviewed	RECK8_HUMAN	Endogenous retrovirus group K member 8 Rec protein (HERV-K115 Rec protein) (HERV-K_8p23.1 provirus Rec protein)	ERVK-8	Homo sapiens (Human)	105	FUNCTION: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity). {ECO:0000250}.	MISCELLANEOUS: Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex.; MISCELLANEOUS: Insertional polymorphism. Provirus present in 16% of tested individuals.; MISCELLANEOUS: Has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HMLM-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3' part of the proviral genome.; MISCELLANEOUS: Intragenic, in first intron of DEFB107 gene.	mRNA transport [GO:0051028]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; mRNA transport [GO:0051028]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity). {ECO:0000250}.
P61576	reviewed	REC04_HUMAN	Endogenous retrovirus group K member 104 Rec protein (HERV-K104 Rec protein) (HERV-K_5q13.3 provirus Rec protein)	HERV-K104	Homo sapiens (Human)	105	FUNCTION: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity). {ECO:0000250}.	MISCELLANEOUS: Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex.; MISCELLANEOUS: This Rec protein is encoded by a human specific provirus.; MISCELLANEOUS: HERV-K104 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HMLM-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3' part of the proviral genome.	mRNA transport [GO:0051028]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; mRNA transport [GO:0051028]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity). {ECO:0000250}.
P61578	reviewed	REC16_HUMAN	Endogenous retrovirus group K member 16 Rec protein (HERV-K_10p14 provirus Rec protein)	ERVK-16	Homo sapiens (Human)	105	FUNCTION: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity). {ECO:0000250}.	MISCELLANEOUS: Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex.; MISCELLANEOUS: Has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HMLM-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3' part of the proviral genome.	mRNA transport [GO:0051028]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; mRNA transport [GO:0051028]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity). {ECO:0000250}.
P61579	reviewed	ERK25_HUMAN	Endogenous retrovirus group K member 25 Rec protein (Endogenous retrovirus group K member 25) (HERV-K_11q22.1 provirus Rec protein)	ERVK-25	Homo sapiens (Human)	105	FUNCTION: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity). {ECO:0000250}.	MISCELLANEOUS: Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex.; MISCELLANEOUS: Has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HMLM-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3' part of the proviral genome.	mRNA transport [GO:0051028]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; mRNA transport [GO:0051028]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm. When in the nucleus, resides in the nucleolus (By similarity). {ECO:0000250}.
P61580	reviewed	NP10_HUMAN	Endogenous retrovirus group K member 10 Np9 protein (HERV-K10 Np9 protein) (HERV-K107 Np9 protein) (HERV-K_5q33.3 provirus Np9 protein)	ERVK-10	Homo sapiens (Human)	75	FUNCTION: May possess a function in tumorigenesis. {ECO:0000250}.	MISCELLANEOUS: Protein expressed at very low level. {ECO:0000250}.; MISCELLANEOUS: This Np9 protein is encoded by a human specific provirus.; MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Np9 proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is encoded by a small exon located at the 3' end of the envelope gene. This exon shares the same splice acceptor site and therefore overlaps HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from an alternate reading frame.; MISCELLANEOUS: Intragenic, in the sixth intron of the SCGD gene.		nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=When overexpressed. {ECO:0000250}.
P61581	reviewed	NP24_HUMAN	Endogenous retrovirus group K member 24 Np9 protein (HERV-K101 Np9 protein) (HERV-K_22q11.21 provirus Np9 protein)	ERVK-24	Homo sapiens (Human)	75	FUNCTION: May possess a function in tumorigenesis.	MISCELLANEOUS: Protein expressed at very low level.; MISCELLANEOUS: This Np9 protein is encoded by a human specific provirus.; MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Np9 proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is encoded by a small exon located at the 3' end of the envelope gene. This exon shares the same splice acceptor site and therefore overlaps HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from an alternate reading frame.; MISCELLANEOUS: Intergenic, closest flanking gene being PRODH.		nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus. Note=When overexpressed.
P61582	reviewed	NP7_HUMAN	Endogenous retrovirus group K member 7 Np9 protein (HERV-K(III) Np9 protein) (HERV-K102 Np9 protein) (HERV-K_1q22 provirus Np9 protein)	ERVK-7	Homo sapiens (Human)	75	FUNCTION: May possess a function in tumorigenesis. {ECO:0000250}.	MISCELLANEOUS: Protein expressed at very low level. {ECO:0000250}.; MISCELLANEOUS: This Np9 protein is encoded by a human specific provirus.; MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Np9 proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is encoded by a small exon located at the 3' end of the envelope gene. This exon shares the same splice acceptor site and therefore overlaps HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from an alternate reading frame.		nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=When overexpressed. {ECO:0000250}.
P61583	reviewed	NP5_HUMAN	Endogenous retrovirus group K member 5 Np9 protein (Endogenous retrovirus K protein 5) (HERV-K(II) Np9 protein) (HERV-K_3q12.3 provirus Np9 protein)	ERVK-5 ERVK5	Homo sapiens (Human)	75	FUNCTION: May possess a function in tumorigenesis. {ECO:0000250}.	MISCELLANEOUS: Protein expressed at very low level. {ECO:0000250}.; MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Np9 proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is encoded by a small exon located at the 3' end of the envelope gene. This exon shares the same splice acceptor site and therefore overlaps HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from an alternate reading frame.; MISCELLANEOUS: Intergenic, closest flanking genes being RPL24 and FLJ23047.		nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=When overexpressed. {ECO:0000250}.
P86434	reviewed	AAS1_HUMAN	Putative uncharacterized protein ADORA2A-AS1 (ADORA2A antisense RNA 1) (ADORA2A antisense gene protein 1)	ADORA2A-AS1 C22orf45	Homo sapiens (Human)	159		MISCELLANEOUS: This protein has no orthologs in other species and appears to be the product of a protein-coding gene which has arisen since divergence from chimp.					
P86478	reviewed	PR20E_HUMAN	Proline-rich protein 20E	PRR20E	Homo sapiens (Human)	221							
P86496	reviewed	PR20A_HUMAN	Proline-rich protein 20A	PRR20A PRR20	Homo sapiens (Human)	221							
Q05C16	reviewed	LRC63_HUMAN	Leucine-rich repeat-containing protein 63	LRRC63	Homo sapiens (Human)	587			signal transduction [GO:0007165]			signal transduction [GO:0007165]	
Q08AI8	reviewed	MB214_HUMAN	Protein mab-21-like 4	MAB21L4 C2orf54	Homo sapiens (Human)	447							
Q08E93	reviewed	F27E3_HUMAN	Protein FAM27E3	FAM27E3	Homo sapiens (Human)	113							
Q0D2K2	reviewed	KLH30_HUMAN	Kelch-like protein 30	KLHL30	Homo sapiens (Human)	578							
Q0D2K5	reviewed	EGFEM_HUMAN	Putative EGF-like and EMI domain-containing protein 1	EGFEM1P C3orf50 NCRNA00259	Homo sapiens (Human)	195					scavenger receptor activity [GO:0005044]	scavenger receptor activity [GO:0005044]	
Q0IIN9	reviewed	ZNFS1_HUMAN	Putative uncharacterized protein ZNF252P-AS1 (ZNF252P antisense RNA 1) (ZNF252P antisense gene protein 1)	ZNF252P-AS1 C8orf77	Homo sapiens (Human)	211							
Q0P5P2	reviewed	CQ067_HUMAN	Uncharacterized protein C17orf67	C17orf67	Homo sapiens (Human)	90				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q0P641	reviewed	CB080_HUMAN	Uncharacterized protein C2orf80	C2orf80	Homo sapiens (Human)	193							
Q0P670	reviewed	SPEM2_HUMAN	Uncharacterized protein SPEM2	SPEM2 C17orf74	Homo sapiens (Human)	501				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q0P6D6	reviewed	CCD15_HUMAN	Coiled-coil domain-containing protein 15	CCDC15	Homo sapiens (Human)	951				centrosome [GO:0005813]		centrosome [GO:0005813]	
Q0P6H9	reviewed	TMM62_HUMAN	Transmembrane protein 62	TMEM62	Homo sapiens (Human)	643				membrane [GO:0016020]	hydrolase activity [GO:0016787]	membrane [GO:0016020]; hydrolase activity [GO:0016787]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q0VAA2	reviewed	LR74A_HUMAN	Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74)	LRRC74A C14orf166B LRRC74	Homo sapiens (Human)	488							
Q0VAA5	reviewed	PLCX2_HUMAN	PI-PLC X domain-containing protein 2	PLCXD2	Homo sapiens (Human)	305			lipid catabolic process [GO:0016042]; signal transduction [GO:0007165]	nucleus [GO:0005634]	phosphoric diester hydrolase activity [GO:0008081]	nucleus [GO:0005634]; phosphoric diester hydrolase activity [GO:0008081]; lipid catabolic process [GO:0016042]; signal transduction [GO:0007165]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22732399}.
Q0VAF6	reviewed	SYCN_HUMAN	Syncollin (Insulin synthesis-associated protein 1)	SYCN INSSA1 SYL	Homo sapiens (Human)	134	FUNCTION: Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity). {ECO:0000250}.		exocytosis [GO:0006887]	secretory granule membrane [GO:0030667]		secretory granule membrane [GO:0030667]; exocytosis [GO:0006887]	SUBCELLULAR LOCATION: Zymogen granule membrane {ECO:0000250|UniProtKB:O35775}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35775}; Lumenal side {ECO:0000250|UniProtKB:O35775}. Zymogen granule lumen {ECO:0000250|UniProtKB:O35775}. Note=Associated in a cholesterol-dependent manner with lipid rafts of zymogen granule membranes. {ECO:0000250|UniProtKB:O35775}.
Q0VDI3	reviewed	TM267_HUMAN	Transmembrane protein 267	TMEM267 C5orf28	Homo sapiens (Human)	215				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q0VF49	reviewed	K2012_HUMAN	Uncharacterized protein KIAA2012	KIAA2012	Homo sapiens (Human)	1180							
Q0VG73	reviewed	YC023_HUMAN	Putative uncharacterized protein LOC152225		Homo sapiens (Human)	95							
Q0Z7S8	reviewed	FABP9_HUMAN	Fatty acid-binding protein 9 (Testis lipid-binding protein) (TLBP) (Testis-type fatty acid-binding protein) (T-FABP)	FABP9	Homo sapiens (Human)	132			long-chain fatty acid transport [GO:0015909]	cytosol [GO:0005829]; nucleus [GO:0005634]	long-chain fatty acid binding [GO:0036041]	cytosol [GO:0005829]; nucleus [GO:0005634]; long-chain fatty acid binding [GO:0036041]; long-chain fatty acid transport [GO:0015909]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q12766	reviewed	HMGX3_HUMAN	HMG domain-containing protein 3 (HMG box-containing protein 3) (Protein SMF)	HMGXB3 KIAA0194 SMF	Homo sapiens (Human)	1292				nucleus [GO:0005634]	DNA binding [GO:0003677]	nucleus [GO:0005634]; DNA binding [GO:0003677]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Q13070	reviewed	GAGE6_HUMAN	G antigen 6 (GAGE-6) (Cancer/testis antigen 4.6) (CT4.6)	GAGE6	Homo sapiens (Human)	117		MISCELLANEOUS: This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
Q13278	reviewed	RIG_HUMAN	Putative protein RIG (Protein regulated in glioma)	RIG	Homo sapiens (Human)	110	FUNCTION: May serve as a molecular marker for or play a role in the malignant progression of glioblastomas. {ECO:0000269|PubMed:9070656}.						
Q13670	reviewed	PM2PB_HUMAN	Putative postmeiotic segregation increased 2-like protein 11 (PMS2-related protein 6) (Putative postmeiotic segregation increased 2 pseudogene 11)	PMS2P11 PMS2L11 PMSR6	Homo sapiens (Human)	270		MISCELLANEOUS: Encoded by one of the numerous copies of postmeiotic segregation increased 2-like genes scattered in the q11-q22 region of the chromosome 7.	phosphorylation [GO:0016310]		kinase activity [GO:0016301]	kinase activity [GO:0016301]; phosphorylation [GO:0016310]	
Q14236	reviewed	EPAG_HUMAN	Early lymphoid activation gene protein (DIAPH2 antisense RNA 1) (DIAPH2 antisense gene protein 1)	DIAPH2-AS1 EPAG	Homo sapiens (Human)	149	FUNCTION: May function as an early signal that helps mediate the activation of T-cells. {ECO:0000269|PubMed:8133036}.		signal transduction [GO:0007165]			signal transduction [GO:0007165]	
Q147U7	reviewed	SMCO1_HUMAN	Single-pass membrane and coiled-coil domain-containing protein 1 (Single-pass membrane protein with coiled-coil domains 1)	SMCO1 C3orf43	Homo sapiens (Human)	214				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q14CX5	reviewed	MF13A_HUMAN	Transmembrane protein 180 (Major facilitator superfamily domain-containing 13A)	MFSD13A C10orf77 TMEM180	Homo sapiens (Human)	517				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q15053	reviewed	K0040_HUMAN	Uncharacterized protein KIAA0040	KIAA0040	Homo sapiens (Human)	99				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q15195	reviewed	PLGA_HUMAN	Plasminogen-like protein A (Plasminogen-like protein A1) (Plasminogen-related protein A)	PLGLA PLGLA1 PLGP2 PRGA	Homo sapiens (Human)	96	FUNCTION: May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction (By similarity). {ECO:0000250}.			extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q156A1	reviewed	ATX8_HUMAN	Ataxin-8 (Protein 1C2)	ATXN8	Homo sapiens (Human)	80		MISCELLANEOUS: It is unknown whether this protein exists in non-SCA8 individuals.		nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16804541}. Note=Present in SCA8-specific 1C2-positive intranuclear inclusions.
Q15846	reviewed	CLUL1_HUMAN	Clusterin-like protein 1 (Retinal-specific clusterin-like protein)	CLUL1	Homo sapiens (Human)	466				extracellular space [GO:0005615]; nucleus [GO:0005634]	misfolded protein binding [GO:0051787]	extracellular space [GO:0005615]; nucleus [GO:0005634]; misfolded protein binding [GO:0051787]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q15940	reviewed	ZNF67_HUMAN	Putative zinc finger protein 726P1	ZNF726P1 ZNF67 ZNF67P	Homo sapiens (Human)	193			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q16473	reviewed	TENXA_HUMAN	Putative tenascin-XA (TN-XA)	TNXA XA	Homo sapiens (Human)	311		MISCELLANEOUS: TNX genes are located in the class III HLA region within a complex locus, named RCCX module, containing genes for RP1/STK19, C4B, CYP21B/CYP21A2 and TNXB. Most chromosomes bear 2 modules, but monomodular and trimodular haplotypes are common in most populations. The bimodular haplotype results from the duplication of the RCCX module, leading to a duplicate containing RP2/RP1 pseudogene, C4A, CYP21A/CYP21A1P and TNXA. TNXA is a duplicated section of TNXB and probably consists in a truncated pseudogene: it contains a 120 bp deletion causing a frameshift and a premature stop codon that probably render the gene non-functional. In some pathologies, an unequal crossover between monomodular and bimodular RCCX results in a chromosome with a TNXB-TNXA hybrid gene, arising from a fusion between the TNXB gene of a monomodular RCCX and the TNXA gene of a bimodular RCCX. The TNXB-TNXA hybrid may correspond to TNXB-Short gene and may produce a functional protein.		extracellular exosome [GO:0070062]		extracellular exosome [GO:0070062]	
Q17RM4	reviewed	CC142_HUMAN	Coiled-coil domain-containing protein 142	CCDC142 PSEC0243	Homo sapiens (Human)	750							
Q17RP2	reviewed	TIGD6_HUMAN	Tigger transposable element-derived protein 6	TIGD6	Homo sapiens (Human)	521				nucleus [GO:0005634]	DNA binding [GO:0003677]	nucleus [GO:0005634]; DNA binding [GO:0003677]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q17RQ9	reviewed	NKPD1_HUMAN	NTPase KAP family P-loop domain-containing protein 1	NKPD1	Homo sapiens (Human)	610				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q1A5X6	reviewed	IQCJ_HUMAN	IQ domain-containing protein J	IQCJ	Homo sapiens (Human)	159							
Q1A5X7	reviewed	WHAL1_HUMAN	Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1 (WAS protein homolog associated with actin, Golgi membranes and microtubules pseudogene 3) (WAS protein homology region 2 domain-containing protein 1-like protein 1) (WH2 domain-containing protein 1-like protein 1) (WHDC1-like protein 1)	WHAMMP3 WHAMML1 WHDC1L1	Homo sapiens (Human)	153							
Q1T7F1	reviewed	CCB42_HUMAN	Putative chemokine-related protein B42		Homo sapiens (Human)	81				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22586462}. Note=No secretion detected.
Q1W209	reviewed	ESRG_HUMAN	Embryonic stem cell-related gene protein (hES cell-related gene protein)	ESRG HESRG	Homo sapiens (Human)	222				nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23628413}.
Q2M238	reviewed	RN3P1_HUMAN	Putative RRN3-like protein RRN3P1 (RNA polymerase I transcription factor homolog pseudogene 1)	RRN3P1	Homo sapiens (Human)	152			transcription initiation at RNA polymerase I promoter [GO:0006361]		RNA polymerase I general transcription initiation factor activity [GO:0001181]	RNA polymerase I general transcription initiation factor activity [GO:0001181]; transcription initiation at RNA polymerase I promoter [GO:0006361]	
Q2M243	reviewed	CCD27_HUMAN	Coiled-coil domain-containing protein 27	CCDC27	Homo sapiens (Human)	656							
Q2M2E5	reviewed	CE064_HUMAN	Uncharacterized protein C5orf64	C5orf64	Homo sapiens (Human)	130				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q2M329	reviewed	CCD96_HUMAN	Coiled-coil domain-containing protein 96	CCDC96	Homo sapiens (Human)	555			cilium assembly [GO:0060271]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]		axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium assembly [GO:0060271]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25074808}.
Q2M3A8	reviewed	MRAS1_HUMAN	Putative uncharacterized protein MRGPRG-AS1 (MRGPRG antisense RNA 1) (MRGPRG antisense gene protein 1)	MRGPRG-AS1 C11orf36 HSD-40 HSD40	Homo sapiens (Human)	158							
Q2TAM9	reviewed	TUSC1_HUMAN	Tumor suppressor candidate gene 1 protein (TSG-9) (TSG9)	TUSC1	Homo sapiens (Human)	212							
Q2TB18	reviewed	ASTE1_HUMAN	Protein asteroid homolog 1	ASTE1 HT001	Homo sapiens (Human)	679	FUNCTION: Possible role in EGF receptor signaling. {ECO:0000250}.				nuclease activity [GO:0004518]	nuclease activity [GO:0004518]	
Q2VPJ9	reviewed	LR75B_HUMAN	Leucine-rich repeat-containing protein 75B (Leucine-rich repeat-containing protein FAM211B)	LRRC75B C22orf36 FAM211B	Homo sapiens (Human)	315	FUNCTION: May suppress myogenic differentiation by modulating MYOG expression and Erk1/2 signaling. {ECO:0000250|UniProtKB:Q7TPD7}.						
Q309B1	reviewed	TR16L_HUMAN	Tripartite motif-containing protein 16-like protein (Tripartite motif-containing protein 70)	TRIM16L TRIM70	Homo sapiens (Human)	348				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q30KP9	reviewed	DB135_HUMAN	Beta-defensin 135 (Defensin, beta 135)	DEFB135	Homo sapiens (Human)	77	FUNCTION: Has antibacterial activity. {ECO:0000305}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q30KQ7	reviewed	DB113_HUMAN	Beta-defensin 113 (Beta-defensin 13) (DEFB-13) (Defensin, beta 113)	DEFB113 DEFB13	Homo sapiens (Human)	82	FUNCTION: Has antibacterial activity. {ECO:0000250}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q32M84	reviewed	BTBDG_HUMAN	BTB/POZ domain-containing protein 16	BTBD16 C10orf87	Homo sapiens (Human)	506							
Q32M92	reviewed	CO032_HUMAN	Uncharacterized protein C15orf32	C15orf32	Homo sapiens (Human)	178							
Q32NC0	reviewed	CR021_HUMAN	UPF0711 protein C18orf21 (HBV X-transactivated gene 13 protein) (HBV XAg-transactivated protein 13)	C18orf21 XTP13 PNAS-124 PNAS-131	Homo sapiens (Human)	220							
Q3B7S5	reviewed	SMI21_HUMAN	Small integral membrane protein 21	SMIM21 C18orf62	Homo sapiens (Human)	101				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q3BBV2	reviewed	NBPF8_HUMAN	Putative neuroblastoma breakpoint family member 8	NBPF8 NBPF8P	Homo sapiens (Human)	869		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q3C1V0	reviewed	M4A18_HUMAN	Membrane-spanning 4-domains subfamily A member 18	MS4A18	Homo sapiens (Human)	400			cell surface receptor signaling pathway [GO:0007166]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; cell surface receptor signaling pathway [GO:0007166]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q3C1V1	reviewed	CK091_HUMAN	Uncharacterized protein C11orf91	C11orf91	Homo sapiens (Human)	193							
Q3C1V9	reviewed	YK041_HUMAN	Putative uncharacterized protein ENSP00000334305		Homo sapiens (Human)	767			intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]	external side of plasma membrane [GO:0009897]		external side of plasma membrane [GO:0009897]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]	
Q3KRA6	reviewed	CB076_HUMAN	UPF0538 protein C2orf76	C2orf76	Homo sapiens (Human)	126							
Q3LHN0	reviewed	KR251_HUMAN	Keratin-associated protein 25-1	KRTAP25-1 KAP25.1	Homo sapiens (Human)	102	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.			cytosol [GO:0005829]; keratin filament [GO:0045095]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; keratin filament [GO:0045095]; structural molecule activity [GO:0005198]	
Q3LHN1	reviewed	KR213_HUMAN	Keratin-associated protein 21-3	KRTAP21-3 KAP21.3	Homo sapiens (Human)	58	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3LI54	reviewed	KR198_HUMAN	Keratin-associated protein 19-8	KRTAP19-8 KAP19.8	Homo sapiens (Human)	63	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3LI58	reviewed	KR211_HUMAN	Keratin-associated protein 21-1	KRTAP21-1 KAP21.1	Homo sapiens (Human)	79	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3LI60	reviewed	KR203_HUMAN	Keratin-associated protein 20-3	KRTAP20-3 KAP20.3	Homo sapiens (Human)	44	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
Q3LI62	reviewed	KR204_HUMAN	Putative keratin-associated protein 20-4	KRTAP20-4 KAP20.4	Homo sapiens (Human)	44	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.			intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
Q3LI63	reviewed	KR201_HUMAN	Keratin-associated protein 20-1	KRTAP20-1 KAP20.1	Homo sapiens (Human)	56	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3LI68	reviewed	KR222_HUMAN	Keratin-associated protein 22-2	KRTAP22-2 KAP22.2	Homo sapiens (Human)	45	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.			intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
Q3MIP1	reviewed	IPIL2_HUMAN	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2	ITPRIPL2	Homo sapiens (Human)	535				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Q3MIV0	reviewed	KR221_HUMAN	Keratin-associated protein 22-1	KRTAP22-1 KAP22.1	Homo sapiens (Human)	48	FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.			cytosol [GO:0005829]; intermediate filament [GO:0005882]		cytosol [GO:0005829]; intermediate filament [GO:0005882]	
Q3MJ40	reviewed	C144B_HUMAN	Putative coiled-coil domain-containing protein 144B (Coiled-coil domain-containing protein 144B, pseudogene)	CCDC144BP CCDC144B	Homo sapiens (Human)	725							
Q3SXM0	reviewed	DC4L1_HUMAN	DDB1- and CUL4-associated factor 4-like protein 1 (WD repeat-containing protein 21B)	DCAF4L1 WDR21B	Homo sapiens (Human)	396				Cul4-RING E3 ubiquitin ligase complex [GO:0080008]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]	
Q3SY05	reviewed	CA157_HUMAN	Putative uncharacterized protein encoded by LINC00303	LINC00303 C1orf157 NCRNA00303	Homo sapiens (Human)	128							
Q3SYA9	reviewed	P12L1_HUMAN	Putative POM121-like protein 1	POM121L1P POM121L1	Homo sapiens (Human)	428							
Q3Y452	reviewed	TDRG1_HUMAN	Testis development-related protein 1	TDRG1	Homo sapiens (Human)	100				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22123530}.
Q3ZCT8	reviewed	KBTBC_HUMAN	Kelch repeat and BTB domain-containing protein 12 (Kelch domain-containing protein 6)	KBTBD12 KLHDC6	Homo sapiens (Human)	623							
Q3ZCU0	reviewed	GVQW3_HUMAN	Protein GVQW3 (GVQW motif-containing protein 3)	GVQW3	Homo sapiens (Human)	254							
Q3ZCV2	reviewed	CMAP2_HUMAN	Ciliary microtubule-associated protein 2 (Lymphocyte expansion molecule)	CIMAP2 LEM LEXM C1orf177	Homo sapiens (Human)	418							
Q3ZLR7	reviewed	SP201_HUMAN	Transcription factor SPT20 homolog-like 1	SUPT20HL1 FAM48B1	Homo sapiens (Human)	823			regulation of transcription by RNA polymerase II [GO:0006357]	SAGA complex [GO:0000124]	transcription coregulator activity [GO:0003712]	SAGA complex [GO:0000124]; transcription coregulator activity [GO:0003712]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q494R0	reviewed	FBAS1_HUMAN	Putative uncharacterized protein FBXL19-AS1 (FBXL19 antisense RNA 1) (FBXL19 antisense gene protein 1)	FBXL19-AS1 NCRNA00095	Homo sapiens (Human)	122							
Q495Y7	reviewed	SPDE7_HUMAN	Putative speedy protein E7 (Speedy protein E7 pseudogene)	SPDYE7P	Homo sapiens (Human)	208					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
Q495Y8	reviewed	SPDE2_HUMAN	Speedy protein E2	SPDYE2	Homo sapiens (Human)	402					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
Q495Z4	reviewed	ASAS1_HUMAN	Putative uncharacterized protein ASB16-AS1 (ASB16 antisense RNA 1) (ASB16 antisense gene protein 1)	ASB16-AS1 C17orf65	Homo sapiens (Human)	193							
Q49A33	reviewed	Z876P_HUMAN	Putative zinc finger protein 876	ZNF876P	Homo sapiens (Human)	203	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q49AM3	reviewed	TTC31_HUMAN	Tetratricopeptide repeat protein 31 (TPR repeat protein 31)	TTC31	Homo sapiens (Human)	519							
Q49AS3	reviewed	L37A5_HUMAN	Putative protein LRRC37A5P (Leucine-rich repeat-containing 37 member A5 pseudogene)	LRRC37A5P C9orf29	Homo sapiens (Human)	106							
Q4AC99	reviewed	1A1L2_HUMAN	Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 (ACC synthase-like protein 2)	ACCSL	Homo sapiens (Human)	568			amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058]		pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]	pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058]	
Q4G0G2	reviewed	H1AS1_HUMAN	Putative uncharacterized protein H1-10-AS1 (H1-10 antisense RNA 1) (H1FX antisense RNA 1)	H1-10-AS1 C3orf47 H1FX-AS1	Homo sapiens (Human)	97							
Q4G0G5	reviewed	SC2B2_HUMAN	Secretoglobin family 2B member 2 (Secretoglobin-like protein)	SCGB2B2 SCGB4A2 SCGBL	Homo sapiens (Human)	96				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q4G0N0	reviewed	GGTA1_HUMAN	Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase (Glycoprotein alpha-galactosyltransferase 1 pseudogene)	GGTA1 GGTA1P	Homo sapiens (Human)	100			leukotriene D4 biosynthetic process [GO:1901750]	Golgi cisterna [GO:0031985]; Golgi cisterna membrane [GO:0032580]		Golgi cisterna [GO:0031985]; Golgi cisterna membrane [GO:0032580]; leukotriene D4 biosynthetic process [GO:1901750]	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P23336}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P23336}.
Q4G0N7	reviewed	F229B_HUMAN	Protein FAM229B	FAM229B C6orf225	Homo sapiens (Human)	80							
Q4QY38	reviewed	DB134_HUMAN	Beta-defensin 134 (Defensin, beta 134)	DEFB134	Homo sapiens (Human)	66	FUNCTION: Has antibacterial activity. {ECO:0000305}.		defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	extracellular region [GO:0005576]		extracellular region [GO:0005576]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q4UJ75	reviewed	A20A4_HUMAN	Putative ankyrin repeat domain-containing protein 20A4 (Ankyrin repeat domain-containing protein 20A4 pseudogene)	ANKRD20A4P ANKRD20A4	Homo sapiens (Human)	823							
Q4V321	reviewed	GAG13_HUMAN	G antigen 13 (GAGE-13) (G antigen 12A) (GAGE-12A)	GAGE13 GAGE12A	Homo sapiens (Human)	117		MISCELLANEOUS: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
Q4V326	reviewed	GAG2E_HUMAN	G antigen 2E (GAGE-2E)	GAGE2E	Homo sapiens (Human)	110		MISCELLANEOUS: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
Q4V348	reviewed	Z658B_HUMAN	Zinc finger protein 658B	ZNF658B	Homo sapiens (Human)	819	FUNCTION: May be involved in transcriptional regulation.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q4VC31	reviewed	MIX23_HUMAN	Protein MIX23 (Coiled-coil domain-containing protein 58)	MIX23 CCDC58	Homo sapiens (Human)	144				mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]		mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]	
Q4VX62	reviewed	CF099_HUMAN	Putative uncharacterized protein LINC02901 (Long intergenic non-protein coding RNA 2901)	LINC02901 C6orf99	Homo sapiens (Human)	202							
Q4VXF1	reviewed	F74A3_HUMAN	Putative protein FAM74A3	FAM74A3	Homo sapiens (Human)	159				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q4W5G0	reviewed	TIGD2_HUMAN	Tigger transposable element-derived protein 2	TIGD2	Homo sapiens (Human)	525				nucleus [GO:0005634]	DNA binding [GO:0003677]	nucleus [GO:0005634]; DNA binding [GO:0003677]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000255|PROSITE-ProRule:PRU00583}.
Q502X0	reviewed	MORN2_HUMAN	MORN repeat-containing protein 2 (MORN motif protein in testis)	MORN2 MOPT	Homo sapiens (Human)	79	FUNCTION: Might have a role in spermatogenesis. {ECO:0000250|UniProtKB:Q6UL01}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	acrosomal vesicle [GO:0001669]; nucleus [GO:0005634]		acrosomal vesicle [GO:0001669]; nucleus [GO:0005634]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q6UL01}. Nucleus {ECO:0000250|UniProtKB:Q6UL01}. Note=Associated with the acrosome during post-meiotic stages of spermatogenesis. Appears to migrate to the nucleus during the final step of spermiogenesis. {ECO:0000250|UniProtKB:Q6UL01}.
Q52LC2	reviewed	VAS1L_HUMAN	V-type proton ATPase subunit S1-like protein (Vacuolar proton pump subunit S1-like protein)	ATP6AP1L	Homo sapiens (Human)	224			regulation of cellular pH [GO:0030641]	proton-transporting V-type ATPase complex [GO:0033176]		proton-transporting V-type ATPase complex [GO:0033176]; regulation of cellular pH [GO:0030641]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q537H7	reviewed	SPT45_HUMAN	Spermatogenesis-associated protein 45	SPATA45 C1orf227 HSD-44 HSD44	Homo sapiens (Human)	98							
Q538Z0	reviewed	LUZP6_HUMAN	Leucine zipper protein 6 (Myeloproliferative disease-associated 6 kDa antigen)	LUZP6 MPD6	Homo sapiens (Human)	58		MISCELLANEOUS: Elicits IgG antibody response in a subset of polycythemia vera patients and as well in patients with chronic myelogenous leukemia and prostate cancer receiving IFNA1 or other therapy, suggesting that it is broadly immunogenic.; MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the MTPN protein from a non-overlapping reading frame. LUZP6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN that is expressed following IRES-mediated alternative initiation of translation at a AUU start codon.					
Q53LP3	reviewed	SWAHC_HUMAN	Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C)	SOWAHC ANKRD57 C2orf26	Homo sapiens (Human)	525							
Q53RE8	reviewed	ANR39_HUMAN	Ankyrin repeat domain-containing protein 39	ANKRD39 HSPC200	Homo sapiens (Human)	183							
Q53SZ7	reviewed	PRR30_HUMAN	Proline-rich protein 30	PRR30 C2orf53	Homo sapiens (Human)	412							
Q569G3	reviewed	CE047_HUMAN	Uncharacterized protein C5orf47	C5orf47	Homo sapiens (Human)	176							
Q569K6	reviewed	CC157_HUMAN	Coiled-coil domain-containing protein 157	CCDC157 KIAA1656	Homo sapiens (Human)	752							
Q587I9	reviewed	SFT2C_HUMAN	Vesicle transport protein SFT2C (SFT2 domain-containing protein 3)	SFT2D3	Homo sapiens (Human)	215	FUNCTION: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. {ECO:0000250|UniProtKB:P38166}.		protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	membrane [GO:0016020]		membrane [GO:0016020]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q58A44	reviewed	PCOTH_HUMAN	Prostate collagen triple helix protein (C1QTNF9B antisense RNA 1) (C1QTNF9B antisense gene protein 1)	PCOTH C1QTNF9B-AS1	Homo sapiens (Human)	107	FUNCTION: May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway.			cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15930275}.
Q59GN2	reviewed	R39L5_HUMAN	Putative ribosomal protein eL39-like 5 (60S ribosomal protein L39 pseudogene 5) (Putative 60S ribosomal protein L39-like 5)	RPL39P5	Homo sapiens (Human)	51			translation [GO:0006412]	cytosolic large ribosomal subunit [GO:0022625]	structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]	
Q5BKU9	reviewed	OXLD1_HUMAN	Oxidoreductase-like domain-containing protein 1	OXLD1 C17orf90	Homo sapiens (Human)	147							
Q5BKY1	reviewed	LRC10_HUMAN	Leucine-rich repeat-containing protein 10	LRRC10	Homo sapiens (Human)	277	FUNCTION: May play important roles in cardiac development and/or cardiac function. {ECO:0000250}.		cardiac muscle cell development [GO:0055013]	cytoskeleton [GO:0005856]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; sarcomere [GO:0030017]	actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]	cytoskeleton [GO:0005856]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; sarcomere [GO:0030017]; actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; cardiac muscle cell development [GO:0055013]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q5BKY6	reviewed	YV018_HUMAN	Putative uncharacterized protein DKFZp434K191		Homo sapiens (Human)	102							
Q5BKY9	reviewed	F133B_HUMAN	Protein FAM133B	FAM133B	Homo sapiens (Human)	247					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q5CZ79	reviewed	AN20B_HUMAN	Ankyrin repeat domain-containing protein 20B (Ankyrin repeat domain-containing protein 20A pseudogene)	ANKRD20A8P ANKRD20B	Homo sapiens (Human)	823							
Q5DJT8	reviewed	CT452_HUMAN	Cancer/testis antigen family 45 member A2 (Cancer/testis antigen 45-2) (Cancer/testis antigen 45A2)	CT45A2 CT45-2	Homo sapiens (Human)	189							
Q5EBN2	reviewed	TRI61_HUMAN	Putative tripartite motif-containing protein 61 (RING finger protein 35)	TRIM61 RNF35	Homo sapiens (Human)	209			protein ubiquitination [GO:0016567]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]	
Q5FWF7	reviewed	FBX48_HUMAN	F-box only protein 48	FBXO48 FBX48	Homo sapiens (Human)	155			SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	SCF ubiquitin ligase complex [GO:0019005]		SCF ubiquitin ligase complex [GO:0019005]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	
Q5GAN3	reviewed	RNS13_HUMAN	Probable inactive ribonuclease-like protein 13	RNASE13	Homo sapiens (Human)	156	FUNCTION: Does not exhibit any ribonuclease activity. {ECO:0000305}.		defense response to Gram-positive bacterium [GO:0050830]	extracellular region [GO:0005576]	nucleic acid binding [GO:0003676]	extracellular region [GO:0005576]; nucleic acid binding [GO:0003676]; defense response to Gram-positive bacterium [GO:0050830]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5GAN4	reviewed	RNS12_HUMAN	Probable inactive ribonuclease-like protein 12	RNASE12	Homo sapiens (Human)	147	FUNCTION: Does not exhibit any ribonuclease activity. {ECO:0000305}.		defense response to Gram-positive bacterium [GO:0050830]	extracellular region [GO:0005576]	nucleic acid binding [GO:0003676]; RNA nuclease activity [GO:0004540]	extracellular region [GO:0005576]; nucleic acid binding [GO:0003676]; RNA nuclease activity [GO:0004540]; defense response to Gram-positive bacterium [GO:0050830]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5GH72	reviewed	XKR7_HUMAN	XK-related protein 7	XKR7 C20orf159 XRG7	Homo sapiens (Human)	579			apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5GH64}; Multi-pass membrane protein {ECO:0000255}.
Q5H943	reviewed	KKLC1_HUMAN	Kita-kyushu lung cancer antigen 1 (KK-LC-1) (Cancer/testis antigen 83)	CT83 CXorf61 KKLC1	Homo sapiens (Human)	113				nucleus [GO:0005634]; plasma membrane [GO:0005886]		nucleus [GO:0005634]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16651449}; Single-pass type II membrane protein {ECO:0000269|PubMed:16651449}.
Q5H9B9	reviewed	BM2KL_HUMAN	Putative BMP-2-inducible kinase-like protein	BMP2KL	Homo sapiens (Human)	411							
Q5H9E4	reviewed	S2553_HUMAN	Solute carrier family 25 member 53 (Mitochondrial carrier triple repeat protein 6)	SLC25A53 MCART6	Homo sapiens (Human)	307				mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	NAD transmembrane transporter activity [GO:0051724]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; NAD transmembrane transporter activity [GO:0051724]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5H9J9	reviewed	T11X2_HUMAN	T-complex protein 11 X-linked protein 2	TCP11X2	Homo sapiens (Human)	407			protein kinase A signaling [GO:0010737]; regulation of sperm capacitation [GO:1902490]	acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126]		acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126]; protein kinase A signaling [GO:0010737]; regulation of sperm capacitation [GO:1902490]	
Q5H9L2	reviewed	TCAL5_HUMAN	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5)	TCEAL5	Homo sapiens (Human)	206	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5HY64	reviewed	FA47C_HUMAN	Putative protein FAM47C	FAM47C	Homo sapiens (Human)	1035							
Q5HYC2	reviewed	K2026_HUMAN	Uncharacterized protein KIAA2026	KIAA2026	Homo sapiens (Human)	2103							
Q5HYL7	reviewed	TM196_HUMAN	Transmembrane protein 196	TMEM196	Homo sapiens (Human)	178				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5HYW3	reviewed	RTL5_HUMAN	Retrotransposon Gag-like protein 5 (Retrotransposon gag domain-containing protein 4)	RTL5 KIAA2001 RGAG4	Homo sapiens (Human)	569		MISCELLANEOUS: RTL5 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. {ECO:0000269|PubMed:16093683}.					
Q5I0X4	reviewed	CF226_HUMAN	Uncharacterized protein C6orf226	C6orf226	Homo sapiens (Human)	101							
Q5JNZ5	reviewed	RS26L_HUMAN	Putative ribosomal protein eS26-like (Putative 40S ribosomal protein S26-like 1)	RPS26P11 RPS26L1	Homo sapiens (Human)	115			translation [GO:0006412]	cytosolic small ribosomal subunit [GO:0022627]	mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735]	cytosolic small ribosomal subunit [GO:0022627]; mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]	
Q5JPB2	reviewed	ZN831_HUMAN	Zinc finger protein 831	ZNF831 C20orf174	Homo sapiens (Human)	1677					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q5JQD4	reviewed	PYY3_HUMAN	Putative peptide YY-3 (Putative peptide YY3) (PYY-III)	PYY3	Homo sapiens (Human)	70			feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]	extracellular space [GO:0005615]	neuropeptide hormone activity [GO:0005184]; neuropeptide Y receptor binding [GO:0031841]	extracellular space [GO:0005615]; neuropeptide hormone activity [GO:0005184]; neuropeptide Y receptor binding [GO:0031841]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q5JRK9	reviewed	GGEE3_HUMAN	Putative G antigen family E member 3 (Prostate-associated gene 2B protein) (PAGE-2B)	PAGE2B GAGEE3	Homo sapiens (Human)	111							
Q5JSJ4	reviewed	INT6L_HUMAN	Integrator complex subunit 6-like (Protein DDX26B)	INTS6L DDX26B	Homo sapiens (Human)	861			snRNA 3'-end processing [GO:0034472]	integrator complex [GO:0032039]		integrator complex [GO:0032039]; snRNA 3'-end processing [GO:0034472]	
Q5JSQ8	reviewed	KHDCL_HUMAN	Putative KHDC1-like protein	KHDC1L	Homo sapiens (Human)	128				cytoplasm [GO:0005737]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; RNA binding [GO:0003723]	
Q5JTB6	reviewed	PLAC9_HUMAN	Placenta-specific protein 9	PLAC9	Homo sapiens (Human)	97				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5JTN6	reviewed	WDR38_HUMAN	WD repeat-containing protein 38	WDR38	Homo sapiens (Human)	314			hematopoietic progenitor cell differentiation [GO:0002244]			hematopoietic progenitor cell differentiation [GO:0002244]	
Q5JTZ5	reviewed	CI152_HUMAN	Uncharacterized protein C9orf152	C9orf152	Homo sapiens (Human)	239							
Q5JUQ0	reviewed	FA78A_HUMAN	Protein FAM78A	FAM78A C9orf59	Homo sapiens (Human)	283							
Q5JUR7	reviewed	TEX30_HUMAN	Testis-expressed protein 30	TEX30 C13orf27	Homo sapiens (Human)	227							
Q5JV73	reviewed	FRPD3_HUMAN	FERM and PDZ domain-containing protein 3	FRMPD3 KIAA1817	Homo sapiens (Human)	1810				cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]		cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]	
Q5JVX7	reviewed	CA141_HUMAN	Uncharacterized protein C1orf141	C1orf141	Homo sapiens (Human)	400							
Q5JXB2	reviewed	UE2NL_HUMAN	Putative ubiquitin-conjugating enzyme E2 N-like (Epididymis tissue protein Li 174)	UBE2NL	Homo sapiens (Human)	153				extracellular exosome [GO:0070062]; nucleus [GO:0005634]	ubiquitin conjugating enzyme activity [GO:0061631]	extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ubiquitin conjugating enzyme activity [GO:0061631]	
Q5JXX7	reviewed	TMM31_HUMAN	Transmembrane protein 31	TMEM31	Homo sapiens (Human)	168				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5JYT7	reviewed	K1755_HUMAN	Uncharacterized protein KIAA1755	KIAA1755	Homo sapiens (Human)	1200			axon guidance [GO:0007411]	cytoplasm [GO:0005737]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; axon guidance [GO:0007411]	
Q5K130	reviewed	CLU1O_HUMAN	Putative uncharacterized protein CLLU1-AS1 (CLLU1 antisense RNA 1) (Chronic lymphocytic leukemia up-regulated protein 1 opposite strand transcript protein)	CLLU1-AS1 CLLU1OS	Homo sapiens (Human)	101							
Q5K131	reviewed	CLLU1_HUMAN	Chronic lymphocytic leukemia up-regulated protein 1	CLLU1	Homo sapiens (Human)	121		MISCELLANEOUS: Tridimensional modeling predicts that it may interact with the IL-4 receptor.; MISCELLANEOUS: This protein has no orthologs in other species and appears to be the product of a protein-coding gene which has arisen since divergence from chimp.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19212335}. Note=Detected in the cytoplasm of chronic lymphocytic leukemia (CLL) cells.
Q5MJ07	reviewed	SPXN5_HUMAN	Sperm protein associated with the nucleus on the X chromosome N5 (Nuclear-associated protein SPAN-Xn5) (SPANX-N5) (SPANX family member N5)	SPANXN5	Homo sapiens (Human)	72							
Q5MJ08	reviewed	SPXN4_HUMAN	Sperm protein associated with the nucleus on the X chromosome N4 (Nuclear-associated protein SPAN-Xn4) (SPANX-N4) (SPANX family member N4)	SPANXN4	Homo sapiens (Human)	99							
Q5MNV8	reviewed	FBX47_HUMAN	F-box only protein 47	FBXO47	Homo sapiens (Human)	452	FUNCTION: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000250}.						
Q5NE16	reviewed	CATL3_HUMAN	Putative inactive cathepsin L-like protein CTSL3P (Cathepsin L3 pseudogene) (HCTSL-s)	CTSL3P CTSL3	Homo sapiens (Human)	218							
Q5QFB9	reviewed	PAPAS_HUMAN	Protein PAPPAS (DIPLA1 antisense RNA 1) (DIPLA1 antisense gene protein 1) (DIPLA1-antisense expressed) (PAPPAS antisense RNA 1) (PAPPAS antisense gene protein 1) (PAPPAS-antisense expressed)	PAPPA-AS1 DIPAS PAPPAS	Homo sapiens (Human)	102				endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5QJ38	reviewed	TCHL1_HUMAN	Trichohyalin-like protein 1 (Basalin) (Protein S100-A17) (S100 calcium-binding protein A17)	TCHHL1 S100A17 THHL1	Homo sapiens (Human)	904					transition metal ion binding [GO:0046914]	transition metal ion binding [GO:0046914]	
Q5R3I4	reviewed	TTC38_HUMAN	Tetratricopeptide repeat protein 38 (TPR repeat protein 38)	TTC38	Homo sapiens (Human)	469				extracellular exosome [GO:0070062]		extracellular exosome [GO:0070062]	
Q5RGS3	reviewed	F74A1_HUMAN	Protein FAM74A1	FAM74A1	Homo sapiens (Human)	127				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5SQ80	reviewed	A20A2_HUMAN	Putative ankyrin repeat domain-containing protein 20A2 (Ankyrin repeat domain-containing protein 20A2 pseudogene)	ANKRD20A2P ANKRD20A2	Homo sapiens (Human)	823							
Q5SQH8	reviewed	CF136_HUMAN	Uncharacterized protein C6orf136	C6orf136	Homo sapiens (Human)	315							
Q5SQS7	reviewed	SH24B_HUMAN	SH2 domain-containing protein 4B	SH2D4B	Homo sapiens (Human)	431				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q5SQS8	reviewed	CJ120_HUMAN	Uncharacterized protein C10orf120	C10orf120	Homo sapiens (Human)	335	FUNCTION: Dispensable for normal development and fertility. {ECO:0000250|UniProtKB:Q8CDT9}.						
Q5SR53	reviewed	CA200_HUMAN	Putative uncharacterized protein PIK3CD-AS1 (PIK3CD antisense RNA 1) (PIK3CD antisense gene protein 1)	PIK3CD-AS1 C1orf200	Homo sapiens (Human)	167							
Q5SRD1	reviewed	TI23B_HUMAN	Mitochondrial import inner membrane translocase subunit Tim23B (TIMM23B)	TIMM23B	Homo sapiens (Human)	188	FUNCTION: May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity). {ECO:0000250|UniProtKB:O14925}.		protein import into mitochondrial matrix [GO:0030150]	TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	protein transmembrane transporter activity [GO:0008320]	TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; protein transmembrane transporter activity [GO:0008320]; protein import into mitochondrial matrix [GO:0030150]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Q5SVJ3	reviewed	SMIP3_HUMAN	Protein SPMIP3 (Sperm-associated microtubule inner protein 3)	SPMIP3 C1orf100	Homo sapiens (Human)	147							
Q5SVZ6	reviewed	ZMYM1_HUMAN	Zinc finger MYM-type protein 1	ZMYM1	Homo sapiens (Human)	1142				nucleus [GO:0005634]	protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q5SWH9	reviewed	TMM69_HUMAN	Transmembrane protein 69	TMEM69 C1orf154 HSPC229	Homo sapiens (Human)	247				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5SWL7	reviewed	PRA14_HUMAN	PRAME family member 14	PRAMEF14	Homo sapiens (Human)	474			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
Q5SWL8	reviewed	PRA19_HUMAN	PRAME family member 19	PRAMEF19	Homo sapiens (Human)	479			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
Q5SY13	reviewed	COAS1_HUMAN	Putative uncharacterized protein encoded by COL5A1-AS1 (COL5A1 antisense RNA 1) (COL5A1 antisense gene protein 1)	COL5A1-AS1 C9orf104	Homo sapiens (Human)	56							
Q5SZB4	reviewed	CI050_HUMAN	Uncharacterized protein C9orf50	C9orf50	Homo sapiens (Human)	431							
Q5T035	reviewed	CI129_HUMAN	Putative uncharacterized protein FAM120A2P (FAM120A2P pseudogene)	FAM120A2P C9orf129	Homo sapiens (Human)	196							
Q5T036	reviewed	F120S_HUMAN	Uncharacterized protein FAM120AOS (FAM120A opposite strand protein)	FAM120AOS C9orf10OS	Homo sapiens (Human)	256							
Q5T089	reviewed	MORN1_HUMAN	MORN repeat-containing protein 1	MORN1	Homo sapiens (Human)	497							
Q5T0U0	reviewed	CC122_HUMAN	Coiled-coil domain-containing protein 122	CCDC122	Homo sapiens (Human)	273							
Q5T0Z8	reviewed	CF132_HUMAN	Uncharacterized protein C6orf132	C6orf132	Homo sapiens (Human)	1188							
Q5T2N8	reviewed	ATD3C_HUMAN	ATPase family AAA domain-containing protein 3C	ATAD3C	Homo sapiens (Human)	411			mitochondrion organization [GO:0007005]	mitochondrion [GO:0005739]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	mitochondrion [GO:0005739]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; mitochondrion organization [GO:0007005]	
Q5T2Q4	reviewed	CCYL2_HUMAN	Cyclin-Y-like protein 2	CCNYL2 C10orf21	Homo sapiens (Human)	361			regulation of canonical Wnt signaling pathway [GO:0060828]	plasma membrane [GO:0005886]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; protein kinase binding [GO:0019901]	plasma membrane [GO:0005886]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; protein kinase binding [GO:0019901]; regulation of canonical Wnt signaling pathway [GO:0060828]	
Q5T319	reviewed	F182B_HUMAN	Protein FAM182B	FAM182B	Homo sapiens (Human)	152		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q5T4H9	reviewed	CSC10_HUMAN	Putative uncharacterized protein encoded by MIR1915-HG (Cancer susceptibility 10 protein) (Cancer susceptibility candidate gene 10 protein) (MIR1915 host gene protein)	MIR1915HG C10orf114 CASC10	Homo sapiens (Human)	136							
Q5T4I8	reviewed	CF052_HUMAN	Putative uncharacterized protein C6orf52	C6orf52	Homo sapiens (Human)	152			selenocysteine incorporation [GO:0001514]	nucleus [GO:0005634]	tRNA binding [GO:0000049]	nucleus [GO:0005634]; tRNA binding [GO:0000049]; selenocysteine incorporation [GO:0001514]	
Q5T5F5	reviewed	A4AS1_HUMAN	Uncharacterized protein ADAMTSL4-AS1 (ADAMTSL4 antisense RNA 1) (ADAMTSL4 antisense gene protein 1)	ADAMTSL4-AS1 C1orf138	Homo sapiens (Human)	129							
Q5T5N4	reviewed	CF118_HUMAN	Uncharacterized protein C6orf118	C6orf118	Homo sapiens (Human)	469							
Q5T6C5	reviewed	AT7L2_HUMAN	Ataxin-7-like protein 2	ATXN7L2	Homo sapiens (Human)	722							
Q5T6M2	reviewed	CF122_HUMAN	Putative uncharacterized protein encoded by LINC00242	LINC00242 C6orf122 NCRNA00242	Homo sapiens (Human)	205							
Q5T6R2	reviewed	TPT2L_HUMAN	Putative phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2P1	TPTE2P1	Homo sapiens (Human)	138							
Q5T6X4	reviewed	F162B_HUMAN	Protein FAM162B	FAM162B C6orf189	Homo sapiens (Human)	162				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5T742	reviewed	ZFAS1_HUMAN	Uncharacterized protein ZNF22-AS1 (ZNF22 antisense RNA 1)	ZNF22-AS1 C10orf25	Homo sapiens (Human)	122				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5T750	reviewed	KPLCE_HUMAN	Protein KPLCE (KPRP N-terminal and LCE C-terminal-like protein) (Skin-specific protein 32)	KPLCE C1orf68 LEP7 XP32	Homo sapiens (Human)	250			epidermis development [GO:0008544]			epidermis development [GO:0008544]	
Q5T764	reviewed	IFT1B_HUMAN	Interferon-induced protein with tetratricopeptide repeats 1B (Interferon-induced protein with tetratricopeptide repeats 1-like protein)	IFIT1B IFIT1L	Homo sapiens (Human)	474			defense response to virus [GO:0051607]	cytosol [GO:0005829]	RNA binding [GO:0003723]	cytosol [GO:0005829]; RNA binding [GO:0003723]; defense response to virus [GO:0051607]	
Q5T8I3	reviewed	EEIG2_HUMAN	EEIG family member 2 (EEIG2)	EEIG2 FAM102B	Homo sapiens (Human)	360							
Q5T8R8	reviewed	DOAS1_HUMAN	Uncharacterized protein DOCK8-AS1 (DOCK8 antisense RNA 1)	DOCK8-AS1 C9orf66	Homo sapiens (Human)	295							
Q5T953	reviewed	IER5L_HUMAN	Immediate early response gene 5-like protein	IER5L	Homo sapiens (Human)	404							
Q5T9Z0	reviewed	TEDM1_HUMAN	Transmembrane epididymal protein 1 (Human epididymis-specific protein 9) (He9)	TEDDM1 HE9	Homo sapiens (Human)	273				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5TAA0	reviewed	TTC22_HUMAN	Tetratricopeptide repeat protein 22 (TPR repeat protein 22)	TTC22	Homo sapiens (Human)	569							
Q5TBE3	reviewed	CI153_HUMAN	Uncharacterized protein C9orf153	C9orf153	Homo sapiens (Human)	101							
Q5TBK1	reviewed	N42L1_HUMAN	NEDD4-binding protein 2-like 1	N4BP2L1 CG081	Homo sapiens (Human)	243							
Q5TC04	reviewed	ATAS1_HUMAN	Putative uncharacterized protein ATP1A1-AS1 (ATP1A1 antisense RNA 1) (ATP1A1 antisense gene protein 1) (ATP1A1 opposite strand protein)	ATP1A1-AS1 ATP1A1OS C1orf203	Homo sapiens (Human)	95							
Q5TC84	reviewed	OGRL1_HUMAN	Opioid growth factor receptor-like protein 1	OGFRL1	Homo sapiens (Human)	451				membrane [GO:0016020]	opioid growth factor receptor activity [GO:0140625]	membrane [GO:0016020]; opioid growth factor receptor activity [GO:0140625]	
Q5TF58	reviewed	IFFO2_HUMAN	Intermediate filament family orphan 2	IFFO2	Homo sapiens (Human)	517				intermediate filament [GO:0005882]		intermediate filament [GO:0005882]	
Q5TG53	reviewed	SEAS1_HUMAN	Putative uncharacterized protein SERTAD4-AS1 (SERTAD4 antisense RNA 1) (SERTAD4 antisense gene protein 1)	SERTAD4-AS1 C1orf133	Homo sapiens (Human)	156							
Q5TGI4	reviewed	SAMD5_HUMAN	Sterile alpha motif domain-containing protein 5 (SAM domain-containing protein 5)	SAMD5 SAMDC1	Homo sapiens (Human)	173				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28388653}.
Q5TGJ6	reviewed	HDGL1_HUMAN	Hepatoma-derived growth factor-like protein 1 (PWWP domain-containing protein 1)	HDGFL1 PWWP1	Homo sapiens (Human)	251			chromatin remodeling [GO:0006338]	nucleus [GO:0005634]		nucleus [GO:0005634]; chromatin remodeling [GO:0006338]	
Q5TGL8	reviewed	PXDC1_HUMAN	PX domain-containing protein 1	PXDC1 C6orf145	Homo sapiens (Human)	231					phosphatidylinositol binding [GO:0035091]	phosphatidylinositol binding [GO:0035091]	
Q5TGP6	reviewed	MROH9_HUMAN	Maestro heat-like repeat-containing protein family member 9	MROH9 C1orf129	Homo sapiens (Human)	573							
Q5TI25	reviewed	NBPFE_HUMAN	Neuroblastoma breakpoint family member 14	NBPF14	Homo sapiens (Human)	921		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q5TYW2	reviewed	A20A1_HUMAN	Ankyrin repeat domain-containing protein 20A1	ANKRD20A1 ANKRD20A	Homo sapiens (Human)	823				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	
Q5TYX0	reviewed	PRAM5_HUMAN	PRAME family member 5	PRAMEF5 PRAMEF23 PRAMEF5L	Homo sapiens (Human)	476			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
Q5U4N7	reviewed	GDAS1_HUMAN	Protein GDF5-AS1, mitochondrial (GDF5 antisense RNA 1) (Growth/differentiation factor 5 opposite strand transcript protein)	GDF5-AS1 GDF5OS	Homo sapiens (Human)	250				mitochondrion [GO:0005739]		mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q5U4P2	reviewed	ASPH1_HUMAN	Aspartate beta-hydroxylase domain-containing protein 1 (EC 1.14.11.-)	ASPHD1	Homo sapiens (Human)	390				membrane [GO:0016020]	dioxygenase activity [GO:0051213]	membrane [GO:0016020]; dioxygenase activity [GO:0051213]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q5U5X8	reviewed	F222A_HUMAN	Protein FAM222A	FAM222A C12orf34	Homo sapiens (Human)	452							
Q5U649	reviewed	CL060_HUMAN	Uncharacterized protein C12orf60	C12orf60	Homo sapiens (Human)	245							
Q5VSP4	reviewed	LC1L1_HUMAN	Putative lipocalin 1-like protein 1 (Lipocalin 1-like pseudogene 1)	LCN1P1 LCN1L1	Homo sapiens (Human)	162	FUNCTION: May bind a variety of ligands including lipids. {ECO:0000250}.			extracellular space [GO:0005615]	small molecule binding [GO:0036094]	extracellular space [GO:0005615]; small molecule binding [GO:0036094]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q5VSR9	reviewed	SPXN1_HUMAN	Sperm protein associated with the nucleus on the X chromosome N1 (Nuclear-associated protein SPAN-Xn1) (SPANX-N1) (SPANX family member N1)	SPANXN1	Homo sapiens (Human)	72							
Q5VT03	reviewed	NTM2D_HUMAN	NUT family member 2D	NUTM2D FAM22D	Homo sapiens (Human)	806							
Q5VT28	reviewed	FAM27_HUMAN	Protein FAM27A/B/C	FAM27B FAM27A FAM27A1 FAM27A2; FAM27C FAM27A3	Homo sapiens (Human)	67							
Q5VT98	reviewed	PRA20_HUMAN	PRAME family member 20	PRAMEF20 PRAMEF21	Homo sapiens (Human)	475			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
Q5VTA0	reviewed	PRA17_HUMAN	PRAME family member 17	PRAMEF17	Homo sapiens (Human)	474			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
Q5VTL7	reviewed	FNDC7_HUMAN	Fibronectin type III domain-containing protein 7	FNDC7	Homo sapiens (Human)	733				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5VU36	reviewed	S31A5_HUMAN	Spermatogenesis-associated protein 31A5 (Protein FAM75A5)	SPATA31A5 FAM75A5	Homo sapiens (Human)	1347	FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5VU92	reviewed	DC121_HUMAN	DDB1- and CUL4-associated factor 12-like protein 1 (WD repeat-containing protein 40B)	DCAF12L1 WDR40B	Homo sapiens (Human)	463				Cul4-RING E3 ubiquitin ligase complex [GO:0080008]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]	
Q5VUR7	reviewed	A20A3_HUMAN	Putative ankyrin repeat domain-containing protein 20A3 (Ankyrin repeat domain-containing protein 20A3 pseudogene)	ANKRD20A3P ANKRD20A3	Homo sapiens (Human)	823							
Q5VUY2	reviewed	ADCL4_HUMAN	Arylacetamide deacetylase-like 4 (EC 3.1.1.-)	AADACL4	Homo sapiens (Human)	407				membrane [GO:0016020]	carboxylic ester hydrolase activity [GO:0052689]	membrane [GO:0016020]; carboxylic ester hydrolase activity [GO:0052689]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Q5VV16	reviewed	FX4L5_HUMAN	Forkhead box protein D4-like 5 (FOXD4-like 5)	FOXD4L5	Homo sapiens (Human)	416			anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Q5VVB8	reviewed	TM244_HUMAN	Putative transmembrane protein 244	TMEM244 C6orf191	Homo sapiens (Human)	128				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5VVC0	reviewed	SPO16_HUMAN	Protein SPO16 homolog (Synaptonemal complex reinforcing element)	SPO16 C1orf146 SCRE	Homo sapiens (Human)	180	FUNCTION: Plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC) thereby stabilizing SC, ensuring progression of meiotic prophase I in male and female germ cells (By similarity). Promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 (By similarity). Required for the localization of TEX11 and MSH4 to recombination intermediates (By similarity). {ECO:0000250|UniProtKB:Q3KQP7}.		reciprocal meiotic recombination [GO:0007131]; synaptonemal complex assembly [GO:0007130]	chromosome [GO:0005694]		chromosome [GO:0005694]; reciprocal meiotic recombination [GO:0007131]; synaptonemal complex assembly [GO:0007130]	SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q3KQP7}.
Q5VVH2	reviewed	FKB1C_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP1C (EC 5.2.1.8)	FKBP1C	Homo sapiens (Human)	108	FUNCTION: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000250|UniProtKB:P62942}.			cytoplasm [GO:0005737]; sarcoplasmic reticulum membrane [GO:0033017]	peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; sarcoplasmic reticulum membrane [GO:0033017]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	
Q5VVP1	reviewed	S31A6_HUMAN	Spermatogenesis-associated protein 31A6 (Protein FAM75A6)	SPATA31A6 FAM75A6	Homo sapiens (Human)	1343	FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5VW00	reviewed	DC122_HUMAN	DDB1- and CUL4-associated factor 12-like protein 2 (WD repeat-containing protein 40C)	DCAF12L2 WDR40C	Homo sapiens (Human)	463				Cul4-RING E3 ubiquitin ligase complex [GO:0080008]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]	
Q5VWI1	reviewed	TCRGL_HUMAN	Transcription elongation regulator 1-like protein	TCERG1L	Homo sapiens (Human)	586				nucleus [GO:0005634]	RNA polymerase binding [GO:0070063]; transcription coregulator activity [GO:0003712]	nucleus [GO:0005634]; RNA polymerase binding [GO:0070063]; transcription coregulator activity [GO:0003712]	
Q5VWK0	reviewed	NBPF6_HUMAN	Neuroblastoma breakpoint family member 6	NBPF6	Homo sapiens (Human)	638		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q5VWM3	reviewed	PRA18_HUMAN	PRAME family member 18	PRAMEF18	Homo sapiens (Human)	479			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
Q5VWM4	reviewed	PRAM8_HUMAN	PRAME family member 8	PRAMEF8 PRAMEF24	Homo sapiens (Human)	474			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
Q5VWM6	reviewed	PRA13_HUMAN	Putative PRAME family member 13	PRAMEF13	Homo sapiens (Human)	474			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
Q5VXD3	reviewed	SAM13_HUMAN	Sterile alpha motif domain-containing protein 13 (SAM domain-containing protein 13)	SAMD13 HSD-42 HSD42	Homo sapiens (Human)	122							
Q5VXH5	reviewed	PRAM7_HUMAN	PRAME family member 7	PRAMEF7	Homo sapiens (Human)	474			negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]	
Q5VXM1	reviewed	CDCP2_HUMAN	CUB domain-containing protein 2	CDCP2	Homo sapiens (Human)	449				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5VYP0	reviewed	S31A3_HUMAN	Spermatogenesis-associated protein 31A3 (Protein FAM75A3)	SPATA31A3 FAM75A3	Homo sapiens (Human)	1347	FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5VYY1	reviewed	ANR22_HUMAN	Ankyrin repeat domain-containing protein 22	ANKRD22	Homo sapiens (Human)	191							
Q5VZ18	reviewed	SHE_HUMAN	SH2 domain-containing adapter protein E	SHE	Homo sapiens (Human)	495					phosphotyrosine residue binding [GO:0001784]	phosphotyrosine residue binding [GO:0001784]	
Q5VZ19	reviewed	TDR10_HUMAN	Tudor domain-containing protein 10	TDRD10 UNQ9380/PRO34205	Homo sapiens (Human)	366					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q5VZ72	reviewed	IZUM3_HUMAN	Izumo sperm-egg fusion protein 3	IZUMO3 C9orf134	Homo sapiens (Human)	239		MISCELLANEOUS: Izumo is the name of a Japanese shrine to marriage.		plasma membrane [GO:0005886]	protein homodimerization activity [GO:0042803]	plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q5VZI3	reviewed	TM268_HUMAN	Transmembrane protein 268	TMEM268 C9orf91	Homo sapiens (Human)	342				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5VZQ5	reviewed	TEX36_HUMAN	Testis-expressed protein 36	TEX36 C10orf122	Homo sapiens (Human)	186							
Q5VZR2	reviewed	NTM2G_HUMAN	NUT family member 2G	NUTM2G FAM22G	Homo sapiens (Human)	741							
Q5VZR4	reviewed	MF14C_HUMAN	Major facilitator superfamily domain-containing 14C pseudogene (Hippocampus abundant transcript-like protein 2)	MFSD14CP HIATL2 MFSD14C	Homo sapiens (Human)	150				membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q5W064	reviewed	LIPJ_HUMAN	Lipase member J (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 1)	LIPJ LIPL1	Homo sapiens (Human)	366			lipid catabolic process [GO:0016042]	intracellular membrane-bounded organelle [GO:0043231]	hydrolase activity, acting on ester bonds [GO:0016788]	intracellular membrane-bounded organelle [GO:0043231]; hydrolase activity, acting on ester bonds [GO:0016788]; lipid catabolic process [GO:0016042]	
Q5W0N0	reviewed	CI057_HUMAN	Uncharacterized protein C9orf57	C9orf57	Homo sapiens (Human)	161				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5W150	reviewed	YT011_HUMAN	Putative uncharacterized protein MGC163334		Homo sapiens (Human)	140							
Q5W188	reviewed	CST9P_HUMAN	Putative cystatin-9-like protein CST9LP1 (Cystatin-9-like pseudogene 1)	CST9LP1	Homo sapiens (Human)	147			antimicrobial humoral response [GO:0019730]	extracellular space [GO:0005615]	cysteine-type endopeptidase inhibitor activity [GO:0004869]	extracellular space [GO:0005615]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; antimicrobial humoral response [GO:0019730]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q5XG85	reviewed	U633C_HUMAN	Putative UPF0633 protein LOC554249		Homo sapiens (Human)	94							
Q629K1	reviewed	TRIQK_HUMAN	Triple QxxK/R motif-containing protein (Triple repetitive-sequence of QXXK/R protein homolog)	TRIQK C8orf83	Homo sapiens (Human)	86	FUNCTION: May play a role in cell growth and maintenance of cell morphology. {ECO:0000250}.			endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18828657}; Single-pass membrane protein {ECO:0000269|PubMed:18828657}.
Q63HN1	reviewed	S31F2_HUMAN	Putative protein SPATA31F2P (Putative protein FAM205B)	SPATA31F2P C9orf144 C9orf144A FAM205B FAM205BP	Homo sapiens (Human)	556							
Q658T7	reviewed	F90A2_HUMAN	Putative protein FAM90A2P	FAM90A2P	Homo sapiens (Human)	463							
Q67FW5	reviewed	B3GNL_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 (BGnT-like protein 1) (Beta1,3-N-acetylglucosaminyltransferase-like protein 1) (Beta3Gn-T-like protein 1) (Beta3GnTL1) (EC 2.4.1.-) (Beta-1,3-N-acetylglucosaminyltransferase 8) (BGnT-8) (Beta-1,3-Gn-T8) (Beta3Gn-T8)	B3GNTL1 B3GNT8	Homo sapiens (Human)	361	FUNCTION: Putative glycosyltransferase. {ECO:0000305}.				glycosyltransferase activity [GO:0016757]	glycosyltransferase activity [GO:0016757]	
Q68CR7	reviewed	LRC66_HUMAN	Leucine-rich repeat-containing protein 66	LRRC66	Homo sapiens (Human)	880			long-term memory [GO:0007616]	membrane [GO:0016020]		membrane [GO:0016020]; long-term memory [GO:0007616]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q68D20	reviewed	PMS2L_HUMAN	Protein PMS2CL (PMS2-C terminal-like protein)	PMS2CL PMS2P13	Homo sapiens (Human)	193							
Q68D42	reviewed	TM215_HUMAN	Transmembrane protein 215	TMEM215	Homo sapiens (Human)	235			negative regulation of retinal cell programmed cell death [GO:0046671]; sprouting angiogenesis [GO:0002040]	membrane [GO:0016020]		membrane [GO:0016020]; negative regulation of retinal cell programmed cell death [GO:0046671]; sprouting angiogenesis [GO:0002040]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q69YL0	reviewed	NCAS2_HUMAN	Protein NCBP2AS2 (Hypoxia-induced angiogenesis regulator) (NCBP2 antisense gene protein 2)	NCBP2AS2 HIAR	Homo sapiens (Human)	99		MISCELLANEOUS: Induced by hypoxia in cancer-associated fibroblasts and promotes tumor angiogenesis by causing increased secretion of VEGFA which leads to endothelial sprouting. {ECO:0000269|PubMed:30723174}.					
Q69YW2	reviewed	STUM_HUMAN	Protein stum homolog	STUM C1orf95	Homo sapiens (Human)	141				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q69YZ2	reviewed	T200B_HUMAN	Transmembrane protein 200B (Transmembrane protein TTMA) (Two transmembrane domain-containing family member B)	TMEM200B TTMB	Homo sapiens (Human)	307				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6B9Z1	reviewed	IGFL4_HUMAN	Insulin growth factor-like family member 4	IGFL4	Homo sapiens (Human)	124				extracellular space [GO:0005615]	signaling receptor binding [GO:0005102]	extracellular space [GO:0005615]; signaling receptor binding [GO:0005102]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6DCA0	reviewed	AMERL_HUMAN	AMMECR1-like protein	AMMECR1L	Homo sapiens (Human)	310				nucleus [GO:0005634]		nucleus [GO:0005634]	
Q6EEV4	reviewed	GL1AD_HUMAN	DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 (DNA-directed RNA polymerase II subunit M, isoforms 4/5)	POLR2M GRINL1A	Homo sapiens (Human)	148		MISCELLANEOUS: The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene.					
Q6GMV3	reviewed	PTRD1_HUMAN	Putative peptidyl-tRNA hydrolase PTRHD1 (EC 3.1.1.29) (Peptidyl-tRNA hydrolase domain-containing protein 1)	PTRHD1 C2orf79	Homo sapiens (Human)	140					aminoacyl-tRNA hydrolase activity [GO:0004045]	aminoacyl-tRNA hydrolase activity [GO:0004045]	
Q6GV28	reviewed	TM225_HUMAN	Transmembrane protein 225	TMEM225 PMP22CD	Homo sapiens (Human)	225	FUNCTION: Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC. {ECO:0000250|UniProtKB:Q9D9S2}.			acrosomal membrane [GO:0002080]		acrosomal membrane [GO:0002080]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q9D9S2}; Multi-pass membrane protein {ECO:0000255}.
Q6ICI0	reviewed	LHPL7_HUMAN	LHFPL tetraspan subfamily member 7 protein (Transmembrane protein 211)	LHFPL7 TMEM211	Homo sapiens (Human)	200				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6IE37	reviewed	OVOS1_HUMAN	Ovostatin homolog 1	OVOS1	Homo sapiens (Human)	1185	FUNCTION: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. {ECO:0000250}.			extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q6IE38	reviewed	ISK14_HUMAN	Serine protease inhibitor Kazal-type 14	SPINK14 SPINK5L2	Homo sapiens (Human)	97	FUNCTION: May be a serine protease inhibitor. {ECO:0000250}.			extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6IPW1	reviewed	CK071_HUMAN	Uncharacterized protein C11orf71	C11orf71	Homo sapiens (Human)	123							
Q6JVE5	reviewed	LCN12_HUMAN	Epididymal-specific lipocalin-12	LCN12	Homo sapiens (Human)	192	FUNCTION: Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity). {ECO:0000250}.			extracellular region [GO:0005576]; extracellular space [GO:0005615]	retinoic acid binding [GO:0001972]	extracellular region [GO:0005576]; extracellular space [GO:0005615]; retinoic acid binding [GO:0001972]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6MZM9	reviewed	PRR27_HUMAN	Proline-rich protein 27	PRR27 C4orf40	Homo sapiens (Human)	219				extracellular exosome [GO:0070062]		extracellular exosome [GO:0070062]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6MZN7	reviewed	HCP5_HUMAN	HLA class I histocompatibility antigen protein P5 (HLA complex protein P5) (Protein P5-1)	HCP5	Homo sapiens (Human)	132		MISCELLANEOUS: Variation Gly-112 is associated with low viral loads in untreated HIV patients. The level of circulating virus in the plasma of HIV patients (viral set point) varies among individuals during the nonsymptomatic phase preceding the progression to AIDS. This polymorphism explains 9.6% of the total variation in set point and is associated with the HLA-B*5701 allele, which has the strongest described protective impact on HIV disease progression. However, it is possible that HPC5 polymorphism, and not HLA-B*5701 allele, plays a direct role in the control in viremia in HIV patients.; MISCELLANEOUS: HCP5 is localized within the MHC class I region, but is not structurally related to MHC class I genes. HCP5 is related in sequence to human endogenous retroviruses HERV-L and HERV-16. It has sequence homology with retroviral Pol genes in HERV retroviral element; thus, it is itself a good candidate to interact with HIV-1, possibly through an antisense mechanism against retroviral transcript.					
Q6NSI1	reviewed	AR26L_HUMAN	Putative ankyrin repeat domain-containing protein 26-like protein	ANKRD26P1	Homo sapiens (Human)	321							
Q6NSI3	reviewed	FA53A_HUMAN	Protein FAM53A (Dorsal neural-tube nuclear protein)	FAM53A	Homo sapiens (Human)	398	FUNCTION: May play an important role in neural development; the dorsomedial roof of the third ventricle. {ECO:0000250|UniProtKB:Q5ZKN5}.		protein import into nucleus [GO:0006606]	nucleus [GO:0005634]		nucleus [GO:0005634]; protein import into nucleus [GO:0006606]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5ZKN5}. Note=Subnuclear distribution. {ECO:0000250|UniProtKB:Q5ZKN5}.
Q6NT46	reviewed	GAG2A_HUMAN	G antigen 2A (GAGE-2A)	GAGE2A GAGE2	Homo sapiens (Human)	116		MISCELLANEOUS: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
Q6NUI1	reviewed	C144L_HUMAN	Putative coiled-coil domain-containing protein 144 N-terminal-like	CCDC144NL	Homo sapiens (Human)	221							
Q6NV74	reviewed	CRCDL_HUMAN	CRACD-like protein	CRACDL C2orf55 KIAA1211L	Homo sapiens (Human)	962							
Q6NVV0	reviewed	MKRN5_HUMAN	Putative makorin-5 (Makorin ring finger protein pseudogene 6) (Makorin ring finger protein pseudogene 9) (Putative RING finger protein 65)	MKRN9P MKRN5 MKRN9 MKRNP6 RNF65 ZNF127L3	Homo sapiens (Human)	33							
Q6NVV1	reviewed	R13P3_HUMAN	Putative ribosomal protein uL13-like (60S ribosomal protein L13a pseudogene 3) (Putative 60S ribosomal protein L13a protein RPL13AP3)	RPL13AP3	Homo sapiens (Human)	102			translation [GO:0006412]	nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]	structural constituent of ribosome [GO:0003735]	nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]	
Q6NXN4	reviewed	D19P1_HUMAN	Putative C-mannosyltransferase DPY19L2P1 (EC 2.4.1.-) (Dpy-19-like protein 2 pseudogene 1) (Protein dpy-19 homolog 2-like 1)	DPY19L2P1	Homo sapiens (Human)	242	FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. {ECO:0000250}.	MISCELLANEOUS: It has been suggested that DPY19L2P1 is an inactive pseudogene from which DPY19L2 has evolved by duplication. However, expressed transcript sequences derived from the DPY19L2P1 locus are known to exist.		membrane [GO:0016020]	glycosyltransferase activity [GO:0016757]	membrane [GO:0016020]; glycosyltransferase activity [GO:0016757]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6NXP6	reviewed	NXRD1_HUMAN	NADP-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) (Pyrroline-5-carboxylate reductase-like protein C14orf148)	NOXRED1 C14orf148	Homo sapiens (Human)	359	FUNCTION: Probable oxidoreductase. {ECO:0000250}.	MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	L-proline biosynthetic process [GO:0055129]		pyrroline-5-carboxylate reductase activity [GO:0004735]	pyrroline-5-carboxylate reductase activity [GO:0004735]; L-proline biosynthetic process [GO:0055129]	
Q6P047	reviewed	CH074_HUMAN	Uncharacterized protein C8orf74	C8orf74	Homo sapiens (Human)	294							
Q6P0A1	reviewed	F180B_HUMAN	Protein FAM180B	FAM180B	Homo sapiens (Human)	183				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6P1M9	reviewed	ARMX5_HUMAN	Armadillo repeat-containing X-linked protein 5	ARMCX5	Homo sapiens (Human)	558							
Q6P1R3	reviewed	MSD2_HUMAN	Myb/SANT-like DNA-binding domain-containing protein 2	MSANTD2 C11orf61	Homo sapiens (Human)	559							
Q6P1X6	reviewed	CH082_HUMAN	UPF0598 protein C8orf82	C8orf82	Homo sapiens (Human)	216							
Q6P2C0	reviewed	WDR93_HUMAN	WD repeat-containing protein 93	WDR93	Homo sapiens (Human)	686			electron transport chain [GO:0022900]	mitochondrial respiratory chain complex I [GO:0005747]		mitochondrial respiratory chain complex I [GO:0005747]; electron transport chain [GO:0022900]	
Q6P2I3	reviewed	FAH2B_HUMAN	Fumarylacetoacetate hydrolase domain-containing protein 2B (EC 3.-.-.-)	FAHD2B	Homo sapiens (Human)	314	FUNCTION: May have hydrolase activity. {ECO:0000250}.				hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]	
Q6P2I7	reviewed	EBLN2_HUMAN	Endogenous Bornavirus-like nucleoprotein 2 (Endogenous Borna-like N element-2) (EBLN-2)	EBLN2 GK006	Homo sapiens (Human)	272	FUNCTION: May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human.	MISCELLANEOUS: Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-2 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.					
Q6P2S7	reviewed	TTC41_HUMAN	Putative tetratricopeptide repeat protein 41 (TPR repeat protein 41) (Grp94-neighboring nucleotidase)	TTC41P GNN	Homo sapiens (Human)	1318				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Q6P3W6	reviewed	NBPFA_HUMAN	Neuroblastoma breakpoint family member 10	NBPF10	Homo sapiens (Human)	3795				cytoplasm [GO:0005737]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; RNA binding [GO:0003723]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q6P3X3	reviewed	TTC27_HUMAN	Tetratricopeptide repeat protein 27 (TPR repeat protein 27)	TTC27	Homo sapiens (Human)	843							
Q6P3X8	reviewed	PGBD2_HUMAN	PiggyBac transposable element-derived protein 2	PGBD2	Homo sapiens (Human)	592					sequence-specific DNA binding [GO:0043565]	sequence-specific DNA binding [GO:0043565]	
Q6P575	reviewed	BGP11_HUMAN	Putative inactive beta-glucuronidase protein GUSBP11 (Beta-glucuronidase pseudogene 11)	GUSBP11	Homo sapiens (Human)	273			carbohydrate metabolic process [GO:0005975]		hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; carbohydrate metabolic process [GO:0005975]	
Q6P5R6	reviewed	RL22L_HUMAN	Ribosomal protein eL22-like (60S ribosomal protein L22-like 1) (Large ribosomal subunit protein eL22-like 1)	RPL22L1	Homo sapiens (Human)	122			cytoplasmic translation [GO:0002181]	ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]	
Q6P7N7	reviewed	TMM81_HUMAN	Transmembrane protein 81	TMEM81 UNQ2788/PRO7178	Homo sapiens (Human)	255				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q6PDB4	reviewed	ZN880_HUMAN	Zinc finger protein 880	ZNF880	Homo sapiens (Human)	577			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	
Q6PEV8	reviewed	F199X_HUMAN	Protein FAM199X	FAM199X CXorf39	Homo sapiens (Human)	388							
Q6PEX7	reviewed	TEX38_HUMAN	Testis-expressed protein 38 (ATPAF1 antisense RNA 1) (ATPAF1 antisense gene protein 1)	TEX38 ATPAF1-AS1 C1orf223	Homo sapiens (Human)	206				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6PGQ1	reviewed	DRIC1_HUMAN	Aspartate-rich protein 1	DRICH1 C22orf43	Homo sapiens (Human)	229							
Q6PIY5	reviewed	ARMD1_HUMAN	Armadillo-like helical domain containing protein 1 (p40)	ARMH1 C1orf228 NCRNA00082	Homo sapiens (Human)	440							
Q6PK57	reviewed	DMP34_HUMAN	Putative GED domain-containing protein DNM1P34 (DNM1 pseudogene 34)	DNM1P34	Homo sapiens (Human)	102					GTP binding [GO:0005525]; GTPase activity [GO:0003924]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	
Q6Q795	reviewed	VBPC1_HUMAN	Putative viral protein-binding protein C1		Homo sapiens (Human)	121				protein-containing complex [GO:0032991]		protein-containing complex [GO:0032991]	
Q6QAJ8	reviewed	TM220_HUMAN	Transmembrane protein 220	TMEM220	Homo sapiens (Human)	160				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6T311	reviewed	ARL9_HUMAN	ADP-ribosylation factor-like protein 9	ARL9	Homo sapiens (Human)	187					GTP binding [GO:0005525]; GTPase activity [GO:0003924]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	
Q6UDR6	reviewed	SPIT4_HUMAN	Kunitz-type protease inhibitor 4	SPINT4 C20orf137	Homo sapiens (Human)	99				extracellular region [GO:0005576]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6URK8	reviewed	SMIP8_HUMAN	Sperm microtubule inner protein 8 (Testis, prostate and placenta-expressed protein)	SPMIP8 TEPP	Homo sapiens (Human)	271	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella. {ECO:0000250|UniProtKB:Q2YDM5}.			cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q2YDM5}. Note=Localizes to the A-tubules of DMTs. {ECO:0000250|UniProtKB:Q2YDM5}.
Q6UWF9	reviewed	F180A_HUMAN	Protein FAM180A	FAM180A UNQ1940/PRO4423	Homo sapiens (Human)	173				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UWH6	reviewed	TX261_HUMAN	Protein TEX261	TEX261 UNQ1882/PRO4325	Homo sapiens (Human)	196			endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of apoptotic process [GO:0043065]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; membrane [GO:0016020]	COPII receptor activity [GO:0097020]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; membrane [GO:0016020]; COPII receptor activity [GO:0097020]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6UWW0	reviewed	LCN15_HUMAN	Lipocalin-15	LCN15 UNQ2541/PRO6093	Homo sapiens (Human)	184				extracellular region [GO:0005576]	small molecule binding [GO:0036094]	extracellular region [GO:0005576]; small molecule binding [GO:0036094]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UXB0	reviewed	F131A_HUMAN	Protein FAM131A	FAM131A C3orf40 UNQ715/PRO1378	Homo sapiens (Human)	366							
Q6UXD1	reviewed	HRCT1_HUMAN	Histidine-rich carboxyl terminus protein 1	HRCT1 UNQ338/PRO537	Homo sapiens (Human)	115				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6UXP3	reviewed	TM14E_HUMAN	Transmembrane protein 14EP	TMEM14EP TMEM14E UNQ9344/PRO34067	Homo sapiens (Human)	125			regulation of heme biosynthetic process [GO:0070453]	mitochondrial membrane [GO:0031966]		mitochondrial membrane [GO:0031966]; regulation of heme biosynthetic process [GO:0070453]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6UXP7	reviewed	F151B_HUMAN	Protein FAM151B	FAM151B UNQ9217/PRO28685	Homo sapiens (Human)	276	FUNCTION: Essential for survival of retinal photoreceptor cells. {ECO:0000250|UniProtKB:D3YUE4}.		photoreceptor cell development [GO:0042461]	extracellular space [GO:0005615]		extracellular space [GO:0005615]; photoreceptor cell development [GO:0042461]	
Q6UXQ8	reviewed	YO002_HUMAN	Putative uncharacterized protein UNQ6190/PRO20217	UNQ6190/PRO20217	Homo sapiens (Human)	127				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UXR4	reviewed	SPA13_HUMAN	Putative serpin A13	SERPINA13P SERPINA13 UNQ6121/PRO20043	Homo sapiens (Human)	307				extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UXR6	reviewed	YI004_HUMAN	Putative uncharacterized protein UNQ6494/PRO21346	UNQ6494/PRO21346	Homo sapiens (Human)	183				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UXS0	reviewed	CL19A_HUMAN	C-type lectin domain family 19 member A	CLEC19A UNQ5810/PRO19627	Homo sapiens (Human)	136				extracellular region [GO:0005576]	carbohydrate binding [GO:0030246]	extracellular region [GO:0005576]; carbohydrate binding [GO:0030246]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UXU0	reviewed	YS002_HUMAN	Putative uncharacterized protein UNQ9165/PRO28630	UNQ9165/PRO28630	Homo sapiens (Human)	137				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UYE1	reviewed	LEU7_HUMAN	Leukemia-associated protein 7 (Deleted in lymphocytic leukemia 7)	DLEU7 LEU7	Homo sapiens (Human)	221							
Q6WQI6	reviewed	HEPN1_HUMAN	Putative cancer susceptibility gene HEPN1 protein	HEPN1	Homo sapiens (Human)	88				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12971969}.
Q6WRX3	reviewed	ZY11A_HUMAN	Protein zyg-11 homolog A	ZYG11A ZYG11	Homo sapiens (Human)	759	FUNCTION: Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC. {ECO:0000250}.			Cul2-RING ubiquitin ligase complex [GO:0031462]		Cul2-RING ubiquitin ligase complex [GO:0031462]	
Q6X4T0	reviewed	CL054_HUMAN	Uncharacterized protein C12orf54	C12orf54 HSD-29 HSD-30 HSD29 HSD30	Homo sapiens (Human)	127		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q6XXX2	reviewed	CU024_HUMAN	Putative uncharacterized protein encoded by LINC00114	LINC00114 C21orf24 NCRNA00114	Homo sapiens (Human)	140							
Q6ZMT9	reviewed	DTHD1_HUMAN	Death domain-containing protein 1	DTHD1	Homo sapiens (Human)	781			signal transduction [GO:0007165]			signal transduction [GO:0007165]	
Q6ZMU1	reviewed	C3P1_HUMAN	Putative protein C3P1	C3P1	Homo sapiens (Human)	363				extracellular space [GO:0005615]	endopeptidase inhibitor activity [GO:0004866]	extracellular space [GO:0005615]; endopeptidase inhibitor activity [GO:0004866]	
Q6ZMV8	reviewed	ZN730_HUMAN	Putative zinc finger protein 730	ZNF730	Homo sapiens (Human)	503	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of DNA-templated transcription [GO:0006355]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q6ZN03	reviewed	CU136_HUMAN	Putative uncharacterized protein encoded by LINC00322	LINC00322 C21orf136 NCRNA00322	Homo sapiens (Human)	302							
Q6ZN92	reviewed	DUTL_HUMAN	Putative inactive deoxyuridine 5'-triphosphate nucleotidohydrolase-like protein FLJ16323 (dUTPase-like protein)		Homo sapiens (Human)	141			dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]		dUTP diphosphatase activity [GO:0004170]; magnesium ion binding [GO:0000287]	dUTP diphosphatase activity [GO:0004170]; magnesium ion binding [GO:0000287]; dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]	
Q6ZNB5	reviewed	XNDC1_HUMAN	Protein XNDC1N (XRCC1 N-terminal domain-containing 1 N-terminal like)	XNDC1N	Homo sapiens (Human)	234			single strand break repair [GO:0000012]	chromosome [GO:0005694]; nucleolus [GO:0005730]	damaged DNA binding [GO:0003684]	chromosome [GO:0005694]; nucleolus [GO:0005730]; damaged DNA binding [GO:0003684]; single strand break repair [GO:0000012]	
Q6ZNG2	reviewed	DBX2_HUMAN	Homeobox protein DBX2 (Developing brain homeobox protein 2)	DBX2	Homo sapiens (Human)	339			regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q6ZNG9	reviewed	KRBA2_HUMAN	KRAB-A domain-containing protein 2	KRBA2	Homo sapiens (Human)	492			DNA integration [GO:0015074]; regulation of DNA-templated transcription [GO:0006355]		nucleic acid binding [GO:0003676]	nucleic acid binding [GO:0003676]; DNA integration [GO:0015074]; regulation of DNA-templated transcription [GO:0006355]	
Q6ZNQ3	reviewed	LRC69_HUMAN	Leucine-rich repeat-containing protein 69	LRRC69	Homo sapiens (Human)	347			signal transduction [GO:0007165]			signal transduction [GO:0007165]	
Q6ZQN5	reviewed	FOXI2_HUMAN	Forkhead box protein I2	FOXI2	Homo sapiens (Human)	318	FUNCTION: Possible transcriptional activator. {ECO:0000250}.		anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin [GO:0000785]; nucleus [GO:0005634]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q6ZQQ2	reviewed	S31D1_HUMAN	Spermatogenesis-associated protein 31D1 (Protein FAM75D1)	SPATA31D1 FAM75D1	Homo sapiens (Human)	1576	FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6ZQT0	reviewed	YD023_HUMAN	Putative uncharacterized protein FLJ45035		Homo sapiens (Human)	140							
Q6ZQV5	reviewed	ZN788_HUMAN	Putative KRAB domain-containing protein ZNF788 (Zinc finger family member 788, pseudogene)	ZNF788P ZNF788	Homo sapiens (Human)	82			regulation of DNA-templated transcription [GO:0006355]	nucleus [GO:0005634]		nucleus [GO:0005634]; regulation of DNA-templated transcription [GO:0006355]	
Q6ZQY2	reviewed	LR74B_HUMAN	Leucine-rich repeat-containing protein 74B	LRRC74B	Homo sapiens (Human)	392							
Q6ZRC1	reviewed	CD050_HUMAN	Uncharacterized protein C4orf50	C4orf50	Homo sapiens (Human)	276							
Q6ZRK6	reviewed	CCD73_HUMAN	Coiled-coil domain-containing protein 73 (Sarcoma antigen NY-SAR-79)	CCDC73	Homo sapiens (Human)	1079							
Q6ZRP0	reviewed	PR23C_HUMAN	Proline-rich protein 23C	PRR23C	Homo sapiens (Human)	262							
Q6ZRR7	reviewed	LRRC9_HUMAN	Leucine-rich repeat-containing protein 9	LRRC9	Homo sapiens (Human)	1453				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q6ZRT6	reviewed	PR23B_HUMAN	Proline-rich protein 23B	PRR23B	Homo sapiens (Human)	265							
Q6ZS02	reviewed	DMP46_HUMAN	Putative GED domain-containing protein DNM1P46 (DNM1 pseudogene 46)	DNM1P46 C15orf51	Homo sapiens (Human)	220							
Q6ZS62	reviewed	COLC1_HUMAN	Colorectal cancer-associated protein 1	COLCA1 C11orf92	Homo sapiens (Human)	124				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24154973}; Single-pass membrane protein {ECO:0000269|PubMed:24154973}. Note=Co-localizes with crystalloid granules of eosinophils and granular organelles of mast cells, neutrophils, macrophages and dendritic cells.
Q6ZSB3	reviewed	CB046_HUMAN	Putative uncharacterized protein encoded by LINC00299	LINC00299 C2orf46 NCRNA00299	Homo sapiens (Human)	139							
Q6ZSC3	reviewed	RBM43_HUMAN	RNA-binding protein 43 (RNA-binding motif protein 43)	RBM43 C2orf38	Homo sapiens (Human)	357					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q6ZSJ8	reviewed	CA122_HUMAN	Uncharacterized protein C1orf122 (Protein ALAESM)	C1orf122	Homo sapiens (Human)	110							
Q6ZSR9	reviewed	YJ005_HUMAN	Uncharacterized protein FLJ45252		Homo sapiens (Human)	355							
Q6ZST2	reviewed	COLDT_HUMAN	Putative uncharacterized protein COL25A1-DT (COL25A1 divergent transcript) (Zinc finger CCHC domain-containing protein 23)	COL25A1-DT ZCCHC23	Homo sapiens (Human)	131					nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	
Q6ZST4	reviewed	LCNL1_HUMAN	Lipocalin-like 1 protein	LCNL1	Homo sapiens (Human)	164					small molecule binding [GO:0036094]	small molecule binding [GO:0036094]	
Q6ZSU1	reviewed	C2G1P_HUMAN	Putative inactive cytochrome P450 2G1 (Cytochrome P450 2G1 pseudogene)	CYP2G1P CYP2GP1	Homo sapiens (Human)	146					heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	
Q6ZT52	reviewed	FA43B_HUMAN	Protein FAM43B	FAM43B	Homo sapiens (Human)	329							
Q6ZTB9	reviewed	ZN833_HUMAN	Putative zinc finger protein 833	ZNF833P ZNF833	Homo sapiens (Human)	187			regulation of gene expression [GO:0010468]	nucleus [GO:0005634]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; regulation of gene expression [GO:0010468]	
Q6ZTK2	reviewed	YP015_HUMAN	Putative uncharacterized protein LOC400499		Homo sapiens (Human)	550							
Q6ZTZ1	reviewed	MSD1_HUMAN	Myb/SANT-like DNA-binding domain-containing protein 1	MSANTD1 C4orf44	Homo sapiens (Human)	278			positive regulation of DNA-templated transcription [GO:0045893]	nuclear body [GO:0016604]		nuclear body [GO:0016604]; positive regulation of DNA-templated transcription [GO:0045893]	
Q6ZU45	reviewed	CL20A_HUMAN	Putative C-type lectin domain family 20 member A	CLEC20A	Homo sapiens (Human)	400					carbohydrate binding [GO:0030246]	carbohydrate binding [GO:0030246]	
Q6ZUA9	reviewed	MROH5_HUMAN	Maestro heat-like repeat family member 5	MROH5	Homo sapiens (Human)	1318				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q6ZUB0	reviewed	S31D4_HUMAN	Spermatogenesis-associated protein 31D4 (Protein FAM75D4)	SPATA31D4 FAM75D4	Homo sapiens (Human)	917	FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.		cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	membrane [GO:0016020]		membrane [GO:0016020]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q6ZUF6	reviewed	NC336_HUMAN	Putative uncharacterized protein encoded by LINC00336	LINC00336 C6orf227 NCRNA00336	Homo sapiens (Human)	198							
Q6ZUL3	reviewed	CH086_HUMAN	Uncharacterized protein LINC03042 (Long intergenic non-protein coding RNA 3042)	LINC03042 C8orf86	Homo sapiens (Human)	223							
Q6ZUS5	reviewed	CC121_HUMAN	Coiled-coil domain-containing protein 121	CCDC121	Homo sapiens (Human)	278							
Q6ZUU3	reviewed	FOXNB_HUMAN	FOXL2 neighbor protein	FOXL2NB C3orf72	Homo sapiens (Human)	175				fibrillar center [GO:0001650]		fibrillar center [GO:0001650]	
Q6ZV70	reviewed	LANC3_HUMAN	LanC-like protein 3	LANCL3	Homo sapiens (Human)	420			carbohydrate metabolic process [GO:0005975]; peptide modification [GO:0031179]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; carbohydrate metabolic process [GO:0005975]; peptide modification [GO:0031179]	
Q6ZV77	reviewed	CI139_HUMAN	Putative uncharacterized protein LINC02908 (Long intergenic non-protein coding RNA 2908)	LINC02908 C9orf139	Homo sapiens (Human)	190							
Q6ZV80	reviewed	CB091_HUMAN	Putative uncharacterized protein LINC02898 (Long intergenic non-protein coding RNA 2898)	LINC02898 C2orf91	Homo sapiens (Human)	131							
Q6ZVK1	reviewed	T179A_HUMAN	Transmembrane protein 179 (Transmembrane protein 179A)	TMEM179 C14orf90 TMEM179A	Homo sapiens (Human)	233				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6ZVN7	reviewed	SEML_HUMAN	Putative protein SEM1, isoform 2	SEM1 C7orf76	Homo sapiens (Human)	128			double-strand break repair via homologous recombination [GO:0000724]	proteasome complex [GO:0000502]		proteasome complex [GO:0000502]; double-strand break repair via homologous recombination [GO:0000724]	
Q6ZVS7	reviewed	F183B_HUMAN	Protein FAM183BP (Testis highly expressed protein 6)	FAM183BP FAM183B THEG6	Homo sapiens (Human)	135				ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]		ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q5NC57}.
Q6ZVT6	reviewed	CF20D_HUMAN	Protein CFAP20DC (Uncharacterized protein C3orf67)	CFAP20DC C3orf67	Homo sapiens (Human)	689							
Q6ZW13	reviewed	CP086_HUMAN	Uncharacterized protein C16orf86	C16orf86	Homo sapiens (Human)	317							
Q6ZWI9	reviewed	RFPLB_HUMAN	Ret finger protein-like 4B (RING finger protein 211)	RFPL4B RNF211	Homo sapiens (Human)	263			protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]	
Q71RG6	reviewed	YH006_HUMAN	Putative chemokine-related protein FP248 (Protein N73)	FP248	Homo sapiens (Human)	208				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q75LS8	reviewed	FKB9L_HUMAN	Putative FK506-binding protein 9-like protein (FK506-binding protein 9-like protein pseudogene)	FKBP9P1 FKBP9L	Homo sapiens (Human)	142				endoplasmic reticulum [GO:0005783]	calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum [GO:0005783]; calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	
Q75MW2	reviewed	ZN767_HUMAN	Protein ZNF767 (Zinc finger protein 767 pseudogene)	ZNF767P ZNF767	Homo sapiens (Human)	155							
Q7L0L9	reviewed	YA043_HUMAN	Transmembrane protein LOC653160		Homo sapiens (Human)	218			phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	membrane [GO:0016020]	G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]; G protein-coupled receptor activity [GO:0004930]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of Rho protein signal transduction [GO:0035025]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q7L4S7	reviewed	ARMX6_HUMAN	Protein ARMCX6	ARMCX6	Homo sapiens (Human)	300	FUNCTION: May regulate the dynamics and distribution of mitochondria in neural cells. {ECO:0000250|UniProtKB:Q8K3A6}.			mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8K3A6}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8BHS6}; Single-pass membrane protein {ECO:0000255}.
Q7Z2F6	reviewed	KRBX5_HUMAN	KRAB domain-containing protein 5	KRBOX5 ZNF720	Homo sapiens (Human)	126			regulation of DNA-templated transcription [GO:0006355]			regulation of DNA-templated transcription [GO:0006355]	
Q7Z2R9	reviewed	SSAS1_HUMAN	Putative uncharacterized protein SSBP3-AS1 (SSBP3 antisense RNA 1) (SSBP3 antisense gene protein 1)	SSBP3-AS1 C1orf191 MSTP128	Homo sapiens (Human)	100				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q7Z2V1	reviewed	TNT_HUMAN	Protein TNT	C16orf82	Homo sapiens (Human)	217							
Q7Z2X7	reviewed	PAGE2_HUMAN	P antigen family member 2 (PAGE-2) (G antigen family C 2) (Prostate-associated gene 2 protein)	PAGE2 GAGEC2 GAGEE2	Homo sapiens (Human)	111							
Q7Z3B0	reviewed	SIM15_HUMAN	Small integral membrane protein 15	SMIM15 C5orf43	Homo sapiens (Human)	74				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q7Z4B0	reviewed	CR020_HUMAN	Putative uncharacterized protein encoded by LINC00305	LINC00305 C18orf20 NCRNA00305	Homo sapiens (Human)	112				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q7Z4S9	reviewed	SH2D6_HUMAN	SH2 domain-containing protein 6	SH2D6	Homo sapiens (Human)	175			intracellular signal transduction [GO:0035556]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; intracellular signal transduction [GO:0035556]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	
Q7Z5D8	reviewed	NANGN_HUMAN	NANOG neighbor homeobox (Homeobox protein C14)	NANOGNB	Homo sapiens (Human)	188			regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]	nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Q7Z5U6	reviewed	WDR53_HUMAN	WD repeat-containing protein 53	WDR53	Homo sapiens (Human)	358							
Q7Z6I8	reviewed	CE024_HUMAN	UPF0461 protein C5orf24	C5orf24	Homo sapiens (Human)	188							
Q7Z6K3	reviewed	PTAR1_HUMAN	Protein prenyltransferase alpha subunit repeat-containing protein 1	PTAR1	Homo sapiens (Human)	402				cytoplasm [GO:0005737]	protein prenyltransferase activity [GO:0008318]	cytoplasm [GO:0005737]; protein prenyltransferase activity [GO:0008318]	
Q7Z7L8	reviewed	CK096_HUMAN	Uncharacterized protein C11orf96 (Protein Ag2 homolog)	C11orf96 AG2	Homo sapiens (Human)	435							
Q86SG4	reviewed	DPCA2_HUMAN	Putative Dresden prostate carcinoma protein 2 (D-PCa-2) (High mobility group nucleosome-binding domain-containing protein 2 pseudogene 46)	HMGN2P46 C15orf21	Homo sapiens (Human)	172			chromatin organization [GO:0006325]	nucleus [GO:0005634]	chromatin binding [GO:0003682]	nucleus [GO:0005634]; chromatin binding [GO:0003682]; chromatin organization [GO:0006325]	
Q86SH4	reviewed	PRNT_HUMAN	Putative testis-specific prion protein (Protein M8)	PRNT	Homo sapiens (Human)	94		MISCELLANEOUS: This putative protein is only present in primates and not in other mammals.		extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86SY8	reviewed	KTAS1_HUMAN	Putative uncharacterized protein KTN1-AS1 (KTN1 antisense RNA 1) (KTN1 antisense gene protein 1)	KTN1-AS1 C14orf33	Homo sapiens (Human)	53							
Q86T23	reviewed	CROL1_HUMAN	Putative ciliary rootlet coiled-coil protein-like 1 protein (Ciliary rootlet coiled-coil protein pseudogene 2)	CROCCP2 CROCCL1	Homo sapiens (Human)	111							
Q86TI4	reviewed	WDR86_HUMAN	WD repeat-containing protein 86	WDR86	Homo sapiens (Human)	376		MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q86TZ1	reviewed	TTC6_HUMAN	Tetratricopeptide repeat protein 6 (TPR repeat protein 6)	TTC6 C14orf25 NCRNA00291	Homo sapiens (Human)	520							
Q86U02	reviewed	CN165_HUMAN	Putative uncharacterized protein encoded by LINC00596	LINC00596 C14orf165	Homo sapiens (Human)	117				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q86U17	reviewed	SPA11_HUMAN	Serpin A11	SERPINA11	Homo sapiens (Human)	422				extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86UD1	reviewed	OAF_HUMAN	Out at first protein homolog (HCV NS5A-transactivated protein 13 target protein 2)	OAF NS5ATP13TP2	Homo sapiens (Human)	273							
Q86UD7	reviewed	TBC26_HUMAN	TBC1 domain family member 26	TBC1D26	Homo sapiens (Human)	250	FUNCTION: May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}.				GTPase activator activity [GO:0005096]	GTPase activator activity [GO:0005096]	
Q86UF4	reviewed	CC190_HUMAN	Coiled-coil domain-containing protein 190	CCDC190 C1orf110	Homo sapiens (Human)	302							
Q86UP9	reviewed	LHPL3_HUMAN	LHFPL tetraspan subfamily member 3 protein (Lipoma HMGIC fusion partner-like 3 protein)	LHFPL3 LHFPL4	Homo sapiens (Human)	236			sensory perception of sound [GO:0007605]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; sensory perception of sound [GO:0007605]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q86V59	reviewed	PNM8A_HUMAN	Paraneoplastic antigen-like protein 8A (PNMA-like protein 1)	PNMA8A PNMAL1	Homo sapiens (Human)	439							
Q86V85	reviewed	GP180_HUMAN	Integral membrane protein GPR180 (Intimal thickness-related receptor)	GPR180 ITR	Homo sapiens (Human)	440			G protein-coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236]	membrane [GO:0016020]		membrane [GO:0016020]; G protein-coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q86VQ1	reviewed	GLCI1_HUMAN	Glucocorticoid-induced transcript 1 protein	GLCCI1	Homo sapiens (Human)	547				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q86VZ2	reviewed	WDR5B_HUMAN	WD repeat-containing protein 5B	WDR5B	Homo sapiens (Human)	330	FUNCTION: May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex. {ECO:0000250}.			Set1C/COMPASS complex [GO:0048188]	histone binding [GO:0042393]	Set1C/COMPASS complex [GO:0048188]; histone binding [GO:0042393]	
Q86WR6	reviewed	CHCT1_HUMAN	CHD1 helical C-terminal domain containing protein 1	CHCT1 C17orf64	Homo sapiens (Human)	236	FUNCTION: May play a role in regulation of apoptosis. {ECO:0000250|UniProtKB:Q9D979}.			cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D979}. Note=Located in the cytoplasm of spermatogonia and spermatocytes. {ECO:0000250|UniProtKB:Q9D979}.
Q86WZ0	reviewed	HEAT4_HUMAN	HEAT repeat-containing protein 4	HEATR4	Homo sapiens (Human)	1026					oxidoreductase activity [GO:0016491]	oxidoreductase activity [GO:0016491]	
Q86X40	reviewed	LRC28_HUMAN	Leucine-rich repeat-containing protein 28	LRRC28 UNQ436/PRO867	Homo sapiens (Human)	367		MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.	signal transduction [GO:0007165]			signal transduction [GO:0007165]	
Q86X53	reviewed	ERIC1_HUMAN	Glutamate-rich protein 1	ERICH1 HSPC319	Homo sapiens (Human)	443							
Q86X59	reviewed	CQ082_HUMAN	Putative uncharacterized protein LINC02875	LINC02875 C17orf82	Homo sapiens (Human)	251							
Q86XG9	reviewed	NBPF5_HUMAN	Putative neuroblastoma breakpoint family member 5	NBPF5P NBPF5	Homo sapiens (Human)	351		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q86XI8	reviewed	ZSWM9_HUMAN	Uncharacterized protein ZSWIM9	ZSWIM9 C19orf68	Homo sapiens (Human)	627							
Q86Y27	reviewed	BAGE5_HUMAN	B melanoma antigen 5 (Cancer/testis antigen 2.5) (CT2.5)	BAGE5	Homo sapiens (Human)	43	FUNCTION: Unknown. Candidate gene encoding tumor antigens.	MISCELLANEOUS: The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.		extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86Y28	reviewed	BAGE4_HUMAN	B melanoma antigen 4 (Cancer/testis antigen 2.4) (CT2.4)	BAGE4 MLL3P	Homo sapiens (Human)	39	FUNCTION: Unknown. Candidate gene encoding tumor antigens.	MISCELLANEOUS: The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.		extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86Y29	reviewed	BAGE3_HUMAN	B melanoma antigen 3 (Cancer/testis antigen 2.3) (CT2.3)	BAGE3	Homo sapiens (Human)	109	FUNCTION: Unknown. Candidate gene encoding tumor antigens.	MISCELLANEOUS: The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.		extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86Y30	reviewed	BAGE2_HUMAN	B melanoma antigen 2 (Cancer/testis antigen 2.2) (CT2.2)	BAGE2	Homo sapiens (Human)	109	FUNCTION: Unknown. Candidate gene encoding tumor antigens.	MISCELLANEOUS: The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.		extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q86YG4	reviewed	NT5D4_HUMAN	5'-nucleotidase domain-containing protein 4	NT5DC4	Homo sapiens (Human)	428					5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]	5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]	
Q8IU53	reviewed	CASC2_HUMAN	Protein CASC2, isoforms 1/2 (Cancer susceptibility candidate gene 2 protein isoforms 1/2)	CASC2 C10orf5	Homo sapiens (Human)	76							
Q8IUI4	reviewed	S29P2_HUMAN	Putative protein SNX29P2 (RUN domain-containing protein 2C) (Sorting nexin 29 protein pseudogene 2)	SNX29P2 RUNDC2C	Homo sapiens (Human)	249							
Q8IV32	reviewed	CCD71_HUMAN	Coiled-coil domain-containing protein 71	CCDC71	Homo sapiens (Human)	467							
Q8IV35	reviewed	WDR49_HUMAN	WD repeat-containing protein 49	WDR49	Homo sapiens (Human)	697							
Q8IV56	reviewed	PRR15_HUMAN	Proline-rich protein 15	PRR15	Homo sapiens (Human)	129	FUNCTION: May have a role in proliferation and/or differentiation. {ECO:0000250}.						
Q8IVB5	reviewed	LIX1L_HUMAN	LIX1-like protein	LIX1L	Homo sapiens (Human)	337			autophagosome maturation [GO:0097352]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; autophagosome maturation [GO:0097352]	
Q8IVE0	reviewed	CROL2_HUMAN	Putative ciliary rootlet coiled-coil protein-like 2 protein (Ciliary rootlet coiled-coil protein pseudogene 3)	CROCCP3 CROCCL2 KIAA1922	Homo sapiens (Human)	287							
Q8IVF1	reviewed	NTM2A_HUMAN	NUT family member 2A	NUTM2A FAM22A KIAA2020	Homo sapiens (Human)	878							
Q8IVJ8	reviewed	APRG1_HUMAN	APRG1 tumor suppressor candidate (AP20 region protein 1)	APRG1 C3orf35	Homo sapiens (Human)	170				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8IVK1	reviewed	GLCM1_HUMAN	Putative glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1)	GLYCAM1	Homo sapiens (Human)	47				plasma membrane [GO:0005886]		plasma membrane [GO:0005886]	
Q8IVU9	reviewed	CBCO1_HUMAN	Ciliary-associated calcium-binding coiled-coil protein 1	CABCOCO1 C10orf107	Homo sapiens (Human)	208	FUNCTION: Calcium-binding protein. May be involved in the control of sperm flagellar movement. {ECO:0000250|UniProtKB:Q8CDT7}.			centrosome [GO:0005813]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]	calcium ion binding [GO:0005509]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8CDT7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8CDT7}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8CDT7}. Note=Colocalized with pericentrin at centrosome of spermatocytes and round spermatids. {ECO:0000250|UniProtKB:Q8CDT7}.
Q8IWA6	reviewed	CCD60_HUMAN	Coiled-coil domain-containing protein 60	CCDC60	Homo sapiens (Human)	550							
Q8IWD5	reviewed	MFS6L_HUMAN	Major facilitator superfamily domain-containing protein 6-like	MFSD6L FP7072	Homo sapiens (Human)	586				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8IWF7	reviewed	U2D2L_HUMAN	Putative ubiquitin-conjugating enzyme E2 D2-like protein (Ubiquitin carrier protein D2-like) (Ubiquitin-conjugating enzyme E2D N-terminal-like) (Ubiquitin-protein ligase D2-like)	UBE2DNL UBE2D2L	Homo sapiens (Human)	75							
Q8IWF9	reviewed	CCD83_HUMAN	Coiled-coil domain-containing protein 83	CCDC83 HSD9	Homo sapiens (Human)	413							
Q8IWN6	reviewed	F223A_HUMAN	Protein FAM223A (SPCX)	FAM223A CXorf52 LINC00204A NCRNA00204	Homo sapiens (Human)	122							
Q8IX95	reviewed	CTGE3_HUMAN	Putative cTAGE family member 3 (Protein cTAGE-3)	CTAGE3P CTAGE3	Homo sapiens (Human)	158	FUNCTION: Tumor-associated antigen.	MISCELLANEOUS: Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL). Expressed in 4 of 11 Mycosis fungoides tissues and in a T-zone lymphoma.					
Q8IXL9	reviewed	IQCF2_HUMAN	IQ domain-containing protein F2	IQCF2	Homo sapiens (Human)	164					calmodulin binding [GO:0005516]	calmodulin binding [GO:0005516]	
Q8IXM7	reviewed	CMA1C_HUMAN	Protein CIMAP1C (Ciliary microtubule associated protein 1C) (Outer dense fiber protein 3-like protein 1)	CIMAP1C ODF3L1	Homo sapiens (Human)	274				cytoskeleton [GO:0005856]		cytoskeleton [GO:0005856]	
Q8IXQ8	reviewed	PDZD9_HUMAN	PDZ domain-containing protein 9	PDZD9 C16orf65	Homo sapiens (Human)	264							
Q8IXR5	reviewed	F178B_HUMAN	Protein FAM178B	FAM178B HSPC234	Homo sapiens (Human)	679							
Q8IXR9	reviewed	CL056_HUMAN	Uncharacterized protein C12orf56	C12orf56	Homo sapiens (Human)	622							
Q8IXS0	reviewed	F217A_HUMAN	Protein FAM217A	FAM217A C6orf146	Homo sapiens (Human)	508							
Q8IY42	reviewed	CD019_HUMAN	Uncharacterized protein C4orf19	C4orf19	Homo sapiens (Human)	314							
Q8IY45	reviewed	AMN1_HUMAN	Protein AMN1 homolog	AMN1	Homo sapiens (Human)	258			SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	microvillus membrane [GO:0031528]; SCF ubiquitin ligase complex [GO:0019005]		microvillus membrane [GO:0031528]; SCF ubiquitin ligase complex [GO:0019005]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	
Q8IYA2	reviewed	C144C_HUMAN	Putative coiled-coil domain-containing protein 144C (Coiled-coil domain-containing protein 144C pseudogene)	CCDC144CP CCDC144C	Homo sapiens (Human)	1237							
Q8IYD2	reviewed	KLD8A_HUMAN	Kelch domain-containing protein 8A (Substitute for delta-EGFR expression 1) (S-delta-E1)	KLHDC8A	Homo sapiens (Human)	350							
Q8IYN6	reviewed	UBAD2_HUMAN	UBA-like domain-containing protein 2	UBALD2 FAM100B	Homo sapiens (Human)	164							
Q8IYQ7	reviewed	THNS1_HUMAN	Threonine synthase-like 1 (TSH1)	THNSL1	Homo sapiens (Human)	743				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q8IZ63	reviewed	PRR22_HUMAN	Proline-rich protein 22	PRR22	Homo sapiens (Human)	422							
Q8IZP6	reviewed	R113B_HUMAN	RING finger protein 113B (Zinc finger protein 183-like 1)	RNF113B RNF161 ZNF183L1	Homo sapiens (Human)	322			snoRNA splicing [GO:0034247]	U2-type spliceosomal complex [GO:0005684]	metal ion binding [GO:0046872]	U2-type spliceosomal complex [GO:0005684]; metal ion binding [GO:0046872]; snoRNA splicing [GO:0034247]	
Q8IZQ5	reviewed	SELH_HUMAN	Selenoprotein H (SelH)	SELENOH C11orf31 SELH	Homo sapiens (Human)	122	FUNCTION: May be involved in a redox-related process. {ECO:0000305}.			Golgi apparatus [GO:0005794]	RNA binding [GO:0003723]	Golgi apparatus [GO:0005794]; RNA binding [GO:0003723]	
Q8IZU2	reviewed	WDR17_HUMAN	WD repeat-containing protein 17	WDR17	Homo sapiens (Human)	1322							
Q8MH63	reviewed	LAT1N_HUMAN	Putative L-type amino acid transporter 1-like protein MLAS (hLAT1 3-transmembrane protein MLAS) (hLAT1 3TM MLAS)	SLC7A5P1 MLAS	Homo sapiens (Human)	180				membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N0U4	reviewed	F185A_HUMAN	Protein FAM185A	FAM185A	Homo sapiens (Human)	392		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q8N0U7	reviewed	CA087_HUMAN	Uncharacterized protein C1orf87	C1orf87	Homo sapiens (Human)	546							
Q8N0V1	reviewed	ZNAS1_HUMAN	Putative uncharacterized protein ZNF295-AS1 (ZNF295 antisense RNA 1) (ZNF295 antisense gene protein 1)	ZNF295-AS1 C21orf121 NCRNA00318 PRED87	Homo sapiens (Human)	137							
Q8N0W5	reviewed	IQCK_HUMAN	IQ domain-containing protein K	IQCK	Homo sapiens (Human)	287							
Q8N0W7	reviewed	FMR1N_HUMAN	FMR1 neighbor protein (Cancer/testis antigen 37) (CT37) (Sarcoma antigen NY-SAR-35)	FMR1NB	Homo sapiens (Human)	255				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N123	reviewed	CPXCR_HUMAN	CPX chromosomal region candidate gene 1 protein (Cancer/testis antigen 77) (CT77)	CPXCR1	Homo sapiens (Human)	301							
Q8N1D5	reviewed	CF107_HUMAN	Cilia- and flagella-associated protein 107	CFAP107 C1orf158	Homo sapiens (Human)	194	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.			axonemal microtubule [GO:0005879]		axonemal microtubule [GO:0005879]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}.
Q8N1P7	reviewed	CRBG2_HUMAN	Beta/gamma crystallin domain-containing protein 2 (Absent in melanoma 1-like protein)	CRYBG2 AIM1L	Homo sapiens (Human)	1661					carbohydrate binding [GO:0030246]	carbohydrate binding [GO:0030246]	
Q8N1Y9	reviewed	YI025_HUMAN	Putative uncharacterized protein FLJ37218		Homo sapiens (Human)	231				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8N239	reviewed	KLH34_HUMAN	Kelch-like protein 34	KLHL34	Homo sapiens (Human)	644				extracellular space [GO:0005615]		extracellular space [GO:0005615]	
Q8N268	reviewed	CT197_HUMAN	Putative uncharacterized protein encoded by LINC02910	LINC02910 C20orf197	Homo sapiens (Human)	126							
Q8N2C3	reviewed	DEPD4_HUMAN	DEP domain-containing protein 4	DEPDC4	Homo sapiens (Human)	294			intracellular signal transduction [GO:0035556]			intracellular signal transduction [GO:0035556]	
Q8N2G6	reviewed	ZCH24_HUMAN	Zinc finger CCHC domain-containing protein 24	ZCCHC24 C10orf56	Homo sapiens (Human)	241					RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	
Q8N2R8	reviewed	FA43A_HUMAN	Protein FAM43A	FAM43A PP7298	Homo sapiens (Human)	423							
Q8N2U0	reviewed	TM256_HUMAN	Transmembrane protein 256	TMEM256 C17orf61	Homo sapiens (Human)	113				extracellular exosome [GO:0070062]; membrane [GO:0016020]		extracellular exosome [GO:0070062]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N319	reviewed	CF223_HUMAN	Putative uncharacterized protein encoded by LINC03040	LINC03040 C6orf223	Homo sapiens (Human)	242							
Q8N326	reviewed	CJ111_HUMAN	Putative uncharacterized protein RPP38-DT (RPP38 divergent transcript protein)	RPP38-DT C10orf111	Homo sapiens (Human)	155				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q8N398	reviewed	VW5B2_HUMAN	von Willebrand factor A domain-containing protein 5B2	VWA5B2	Homo sapiens (Human)	1242							
Q8N412	reviewed	STPG2_HUMAN	Sperm-tail PG-rich repeat-containing protein 2	STPG2 C4orf37	Homo sapiens (Human)	459							
Q8N446	reviewed	ZN843_HUMAN	Zinc finger protein 843	ZNF843	Homo sapiens (Human)	348					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q8N485	reviewed	LIX1_HUMAN	Protein limb expression 1 homolog	LIX1 C5orf11	Homo sapiens (Human)	282			autophagosome maturation [GO:0097352]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; autophagosome maturation [GO:0097352]	
Q8N4B5	reviewed	PRR18_HUMAN	Proline-rich protein 18	PRR18	Homo sapiens (Human)	295							
Q8N4C9	reviewed	CQ078_HUMAN	Uncharacterized protein C17orf78	C17orf78	Homo sapiens (Human)	275				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8N4E4	reviewed	PDCL2_HUMAN	Phosducin-like protein 2	PDCL2	Homo sapiens (Human)	241			protein folding [GO:0006457]	cytoplasm [GO:0005737]		cytoplasm [GO:0005737]; protein folding [GO:0006457]	
Q8N4K4	reviewed	RPRML_HUMAN	Reprimo-like protein	RPRML	Homo sapiens (Human)	120				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8N4L4	reviewed	SPEM1_HUMAN	Spermatid maturation protein 1	SPEM1 C17orf83	Homo sapiens (Human)	309	FUNCTION: Required for proper cytoplasm removal during spermatogenesis. {ECO:0000250}.		flagellated sperm motility [GO:0030317]; sperm individualization [GO:0007291]	cytoplasm [GO:0005737]; membrane [GO:0016020]		cytoplasm [GO:0005737]; membrane [GO:0016020]; flagellated sperm motility [GO:0030317]; sperm individualization [GO:0007291]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250}.
Q8N4P6	reviewed	LRC71_HUMAN	Leucine-rich repeat-containing protein 71	LRRC71 C1orf92	Homo sapiens (Human)	559							
Q8N4S7	reviewed	PAQR4_HUMAN	Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV)	PAQR4	Homo sapiens (Human)	273				membrane [GO:0016020]	signaling receptor activity [GO:0038023]	membrane [GO:0016020]; signaling receptor activity [GO:0038023]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N4V2	reviewed	SVOP_HUMAN	Synaptic vesicle 2-related protein (SV2-related protein)	SVOP	Homo sapiens (Human)	548				basal plasma membrane [GO:0009925]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	transmembrane transporter activity [GO:0022857]	basal plasma membrane [GO:0009925]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q8N4W6	reviewed	DJC22_HUMAN	DnaJ homolog subfamily C member 22	DNAJC22	Homo sapiens (Human)	341	FUNCTION: May function as a co-chaperone.			membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N535	reviewed	CB052_HUMAN	Putative uncharacterized protein encoded by LINC00471	LINC00471 C2orf52	Homo sapiens (Human)	108							
Q8N5C1	reviewed	CAHM5_HUMAN	Calcium homeostasis modulator protein 5 (Protein FAM26E)	CALHM5 C6orf188 FAM26E	Homo sapiens (Human)	309	FUNCTION: Pore-forming subunit of a voltage-gated ion channel. {ECO:0000250|UniProtKB:Q8IU99}.			membrane [GO:0016020]	monoatomic cation channel activity [GO:0005261]	membrane [GO:0016020]; monoatomic cation channel activity [GO:0005261]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N5Q1	reviewed	GAR5B_HUMAN	Golgi-associated RAB2 interactor protein 5B	GARIN5B C19orf16 FAM71E2	Homo sapiens (Human)	922							
Q8N5S3	reviewed	CB073_HUMAN	Uncharacterized protein C2orf73	C2orf73	Homo sapiens (Human)	287							
Q8N5U0	reviewed	CK042_HUMAN	Uncharacterized protein C11orf42	C11orf42	Homo sapiens (Human)	333							
Q8N5W8	reviewed	FA24B_HUMAN	Protein FAM24B	FAM24B	Homo sapiens (Human)	94				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N614	reviewed	TM156_HUMAN	Transmembrane protein 156	TMEM156	Homo sapiens (Human)	296				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N6C7	reviewed	PGSF1_HUMAN	Putative uncharacterized protein encoded by MIR7-3HG (Pituitary gland-specific factor 1)	MIR7-3HG C19orf30 LINC00306 NCRNA00306 PGSF1	Homo sapiens (Human)	128		MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q8N6G2	reviewed	TEX26_HUMAN	Testis-expressed protein 26	TEX26 C13orf26	Homo sapiens (Human)	289				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q8N6L7	reviewed	TM252_HUMAN	Transmembrane protein 252	TMEM252 C9orf71	Homo sapiens (Human)	170				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N6N2	reviewed	TTC9B_HUMAN	Tetratricopeptide repeat protein 9B (TPR repeat protein 9B)	TTC9B	Homo sapiens (Human)	239		MISCELLANEOUS: [Isoform 2]: May be due to an intron retention. {ECO:0000305}.					
Q8N6Q8	reviewed	MET25_HUMAN	Probable methyltransferase-like protein 25 (EC 2.1.1.-)	METTL25 C12orf26	Homo sapiens (Human)	603	FUNCTION: Probable methyltransferase. {ECO:0000305}.		methylation [GO:0032259]		S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; methylation [GO:0032259]	
Q8N6V4	reviewed	CJ053_HUMAN	UPF0728 protein C10orf53	C10orf53	Homo sapiens (Human)	93							
Q8N755	reviewed	S66A3_HUMAN	Solute carrier family 66 member 3 (PQ-loop repeat-containing protein 3)	SLC66A3 C2orf22 PQLC3	Homo sapiens (Human)	202				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N769	reviewed	CN178_HUMAN	Uncharacterized protein C14orf178	C14orf178	Homo sapiens (Human)	122							
Q8N7C4	reviewed	TM217_HUMAN	Transmembrane protein 217	TMEM217 C6orf128	Homo sapiens (Human)	229				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N7L0	reviewed	F216B_HUMAN	Protein FAM216B	FAM216B C13orf30	Homo sapiens (Human)	139							
Q8N7N1	reviewed	F86B1_HUMAN	Putative protein N-methyltransferase FAM86B1 (EC 2.1.1.-)	FAM86B1	Homo sapiens (Human)	296			methylation [GO:0032259]		protein-lysine N-methyltransferase activity [GO:0016279]	protein-lysine N-methyltransferase activity [GO:0016279]; methylation [GO:0032259]	
Q8N7Q2	reviewed	CEAS1_HUMAN	Putative uncharacterized protein CELF2-AS1 (CELF2 antisense RNA 1) (CELF2 antisense gene protein 1)	CELF2-AS1 C10orf31	Homo sapiens (Human)	184				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8N7R1	reviewed	P1L12_HUMAN	POM121-like protein 12	POM121L12	Homo sapiens (Human)	296							
Q8N7S6	reviewed	ARI2O_HUMAN	Uncharacterized protein ARIH2OS (Ariadne-2 homolog opposite strand protein)	ARIH2OS C3orf71	Homo sapiens (Human)	290				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8N7U9	reviewed	CQ054_HUMAN	Putative uncharacterized protein encoded by LINC00469	LINC00469 C17orf54	Homo sapiens (Human)	141							
Q8N7X1	reviewed	RMXL3_HUMAN	RNA-binding motif protein, X-linked-like-3	RBMXL3 CXorf55	Homo sapiens (Human)	1067			mRNA splicing, via spliceosome [GO:0000398]	U12-type spliceosomal complex [GO:0005689]	mRNA binding [GO:0003729]; snRNA binding [GO:0017069]	U12-type spliceosomal complex [GO:0005689]; mRNA binding [GO:0003729]; snRNA binding [GO:0017069]; mRNA splicing, via spliceosome [GO:0000398]	
Q8N7X2	reviewed	STPG3_HUMAN	Protein STPG3 (Sperm-tail PG-rich repeat-containing protein 3)	STPG3 C9orf173	Homo sapiens (Human)	386		MISCELLANEOUS: [Isoform 1]: Dubious isoform produced through aberrant splice sites. {ECO:0000305}.		cytoskeleton [GO:0005856]		cytoskeleton [GO:0005856]	
Q8N7X8	reviewed	SIGL1_HUMAN	SIGLEC family-like protein 1	SIGLECL1 C19orf75	Homo sapiens (Human)	197				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8N7Y1	reviewed	KIAS3_HUMAN	Putative uncharacterized protein KIRREL3-AS3 (KIRREL3 antisense RNA 1) (KIRREL3 antisense gene protein 1) (Proline-rich protein 10)	KIRREL3-AS3 NCRNA00288 PRR10	Homo sapiens (Human)	241							
Q8N7Z2	reviewed	GG6L1_HUMAN	Golgin subfamily A member 6-like protein 1	GOLGA6L1	Homo sapiens (Human)	668							
Q8N808	reviewed	S35G3_HUMAN	Solute carrier family 35 member G3 (Acyl-malonyl-condensing enzyme 1) (Transmembrane protein 21A)	SLC35G3 AMAC1 TMEM21A	Homo sapiens (Human)	338		MISCELLANEOUS: The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N813	reviewed	PR23E_HUMAN	Proline-rich protein 23E	PRR23E C3orf56	Homo sapiens (Human)	242							
Q8N816	reviewed	TMM99_HUMAN	Uncharacterized protein KRT10-AS1 (Transmembrane protein 99)	KRT10-AS1 TMEM99	Homo sapiens (Human)	258				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N888	reviewed	BCOR2_HUMAN	Putative BCoR-like protein 2 (BCL-6 corepressor pseudogene 1) (BCL-6 corepressor-like protein 2)	BCORP1 BCORL2	Homo sapiens (Human)	145							
Q8N8A8	reviewed	F169B_HUMAN	Protein FAM169BP (FAM169BP pseudogene)	FAM169BP FAM169B KIAA0888L	Homo sapiens (Human)	192							
Q8N8D7	reviewed	NKAI3_HUMAN	Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3) (Protein FAM77D)	NKAIN3 FAM77D	Homo sapiens (Human)	197			regulation of sodium ion transport [GO:0002028]	plasma membrane [GO:0005886]		plasma membrane [GO:0005886]; regulation of sodium ion transport [GO:0002028]	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N8D9	reviewed	IRAS1_HUMAN	Uncharacterized protein IRF1-AS1 (IRF1 antisense RNA 1)	IRF1-AS1 C5orf56	Homo sapiens (Human)	126							
Q8N8E1	reviewed	MAAS1_HUMAN	Putative uncharacterized protein encoded by MAPKAPK5-AS1 (MAPKAPK5 antisense RNA 1) (MAPKAPK5 antisense gene protein 1)	MAPKAPK5-AS1 C12orf47	Homo sapiens (Human)	139							
Q8N8H1	reviewed	ZN321_HUMAN	Putative protein ZNF321 (Zinc finger protein 321 pseudogene)	ZNF321P ZNF321	Homo sapiens (Human)	164							
Q8N8I0	reviewed	SAM12_HUMAN	Sterile alpha motif domain-containing protein 12 (SAM domain-containing protein 12)	SAMD12	Homo sapiens (Human)	201			transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasmic side of plasma membrane [GO:0009898]		cytoplasmic side of plasma membrane [GO:0009898]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	
Q8N8I6	reviewed	CQ055_HUMAN	Putative uncharacterized protein encoded by LINC00482	LINC00482 C17orf55	Homo sapiens (Human)	264							
Q8N8J7	reviewed	F241A_HUMAN	Uncharacterized protein FAM241A	FAM241A C4orf32	Homo sapiens (Human)	132				Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]		Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Q8N8L6	reviewed	ARL10_HUMAN	ADP-ribosylation factor-like protein 10	ARL10 ARL10A	Homo sapiens (Human)	244					GTP binding [GO:0005525]; GTPase activity [GO:0003924]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	
Q8N8Z3	reviewed	PRR26_HUMAN	Putative uncharacterized protein DIP2C-AS1 (DIP2C antisense RNA 1) (Proline-rich protein 26)	DIP2C-AS1 C10orf108 PRR26	Homo sapiens (Human)	221							
Q8N910	reviewed	CO056_HUMAN	Putative uncharacterized protein PAK6-AS1 (PAK6 antisense RNA 1)	PAK6-AS1 C15orf56	Homo sapiens (Human)	161							
Q8N945	reviewed	PRLD2_HUMAN	PRELI domain-containing protein 2	PRELID2	Homo sapiens (Human)	189			phospholipid transport [GO:0015914]	mitochondrial intermembrane space [GO:0005758]	phosphatidic acid transfer activity [GO:1990050]	mitochondrial intermembrane space [GO:0005758]; phosphatidic acid transfer activity [GO:1990050]; phospholipid transport [GO:0015914]	
Q8N9B4	reviewed	ANR42_HUMAN	Ankyrin repeat domain-containing protein 42	ANKRD42	Homo sapiens (Human)	389				nucleus [GO:0005634]	NF-kappaB binding [GO:0051059]	nucleus [GO:0005634]; NF-kappaB binding [GO:0051059]	
Q8N9C0	reviewed	IGS22_HUMAN	Immunoglobulin superfamily member 22 (IgSF22)	IGSF22	Homo sapiens (Human)	903							
Q8N9H9	reviewed	CA127_HUMAN	Uncharacterized protein C1orf127	C1orf127	Homo sapiens (Human)	656							
Q8N9R0	reviewed	CP081_HUMAN	Putative uncharacterized protein encoded by LINC00304	LINC00304 C16orf81 NCRNA00304	Homo sapiens (Human)	145							
Q8N9R6	reviewed	CDRT4_HUMAN	CMT1A duplicated region transcript 4 protein	CDRT4	Homo sapiens (Human)	152							
Q8N9T2	reviewed	CX042_HUMAN	Putative uncharacterized protein CXorf42 (NF-kappa-B-activating protein pseudogene 1)	NKAPP1 CXorf42	Homo sapiens (Human)	125							
Q8N9V3	reviewed	WSDU1_HUMAN	WD repeat, SAM and U-box domain-containing protein 1	WDSUB1 WDSAM1	Homo sapiens (Human)	476			protein ubiquitination [GO:0016567]		ubiquitin-protein transferase activity [GO:0004842]	ubiquitin-protein transferase activity [GO:0004842]; protein ubiquitination [GO:0016567]	
Q8N9W7	reviewed	YO010_HUMAN	Putative transmembrane protein FLJ36131		Homo sapiens (Human)	124				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8N9X5	reviewed	TMM75_HUMAN	Putative protein encoded by LINC02912	LINC02912 TMEM75	Homo sapiens (Human)	138				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Q8N9Z2	reviewed	CC71L_HUMAN	Coiled-coil domain-containing protein 71L	CCDC71L C7orf74	Homo sapiens (Human)	235							
Q8NA57	reviewed	CL050_HUMAN	Uncharacterized protein C12orf50	C12orf50	Homo sapiens (Human)	414			poly(A)+ mRNA export from nucleus [GO:0016973]			poly(A)+ mRNA export from nucleus [GO:0016973]	
Q8NA66	reviewed	CNBD1_HUMAN	Cyclic nucleotide-binding domain-containing protein 1	CNBD1	Homo sapiens (Human)	436							
Q8NA70	reviewed	FA47B_HUMAN	Protein FAM47B	FAM47B	Homo sapiens (Human)	645							
Q8NA75	reviewed	DC4L2_HUMAN	DDB1- and CUL4-associated factor 4-like protein 2 (WD repeat-containing protein 21C)	DCAF4L2 WDR21C	Homo sapiens (Human)	395				Cul4-RING E3 ubiquitin ligase complex [GO:0080008]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]	
Q8NAA5	reviewed	LR75A_HUMAN	Leucine-rich repeat-containing protein 75A (Leucine-rich repeat-containing protein FAM211A)	LRRC75A C17orf76 FAM211A	Homo sapiens (Human)	344				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q8NAA6	reviewed	CO053_HUMAN	Putative uncharacterized protein encoded by LINC02694	LINC02694 C15orf53	Homo sapiens (Human)	179							
Q8NAB2	reviewed	KBTB3_HUMAN	Kelch repeat and BTB domain-containing protein 3 (BTB and kelch domain-containing protein 3)	KBTBD3 BKLHD3	Homo sapiens (Human)	612							
Q8NAJ2	reviewed	CI106_HUMAN	Putative uncharacterized protein encoded by LINC02913	LINC02913 C9orf106	Homo sapiens (Human)	232							
Q8NAP1	reviewed	CAST3_HUMAN	Putative protein CASTOR3P (CASTOR3 pseudogene) (STAG3 opposite strand transcript protein)	CASTOR3P CASTOR3 GATS STAG3OS	Homo sapiens (Human)	163			cellular response to L-arginine [GO:1903577]; negative regulation of TORC1 signaling [GO:1904262]	cytosol [GO:0005829]		cytosol [GO:0005829]; cellular response to L-arginine [GO:1903577]; negative regulation of TORC1 signaling [GO:1904262]	
Q8NAV2	reviewed	CH058_HUMAN	Uncharacterized protein C8orf58	C8orf58	Homo sapiens (Human)	365							
Q8NBB2	reviewed	STAS1_HUMAN	Putative uncharacterized protein ST20-AS1 (ST20 antisense RNA 1) (ST20 antisense gene protein 1)	ST20-AS1 C15orf37	Homo sapiens (Human)	130							
Q8NBC4	reviewed	CT203_HUMAN	Uncharacterized protein C20orf203	C20orf203	Homo sapiens (Human)	194		MISCELLANEOUS: Originated from non-coding DNA sequences (insertion of repeat elements especially Alu). Seems to exist only in human.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20376170}.
Q8NBE8	reviewed	KLH23_HUMAN	Kelch-like protein 23	KLHL23	Homo sapiens (Human)	558							
Q8NBP0	reviewed	TTC13_HUMAN	Tetratricopeptide repeat protein 13 (TPR repeat protein 13)	TTC13 PSEC0076	Homo sapiens (Human)	860							
Q8NBP5	reviewed	MFSD9_HUMAN	Major facilitator superfamily domain-containing protein 9	MFSD9 PSEC0066	Homo sapiens (Human)	474				membrane [GO:0016020]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; transmembrane transporter activity [GO:0022857]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NBR9	reviewed	CK072_HUMAN	Uncharacterized protein NDUFV1-DT (NDUFV1 divergent transcript)	NDUFV1-DT C11orf72	Homo sapiens (Human)	251							
Q8NBT3	reviewed	TM145_HUMAN	Transmembrane protein 145	TMEM145	Homo sapiens (Human)	493			G protein-coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236]	membrane [GO:0016020]		membrane [GO:0016020]; G protein-coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NBZ9	reviewed	NEAS1_HUMAN	Putative uncharacterized protein NEXN-AS1 (NEXN antisense RNA 1)	NEXN-AS1 C1orf118	Homo sapiens (Human)	246							
Q8NC38	reviewed	CA213_HUMAN	Putative uncharacterized protein ZNF436-AS1 (ZNF436 antisense RNA 1) (ZNF436 antisense gene protein 1)	ZNF436-AS1 C1orf213	Homo sapiens (Human)	126							
Q8NC54	reviewed	KCT2_HUMAN	Keratinocyte-associated transmembrane protein 2	KCT2 C5orf15 HTGN29	Homo sapiens (Human)	265				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8NCJ5	reviewed	SPRY3_HUMAN	SPRY domain-containing protein 3	SPRYD3	Homo sapiens (Human)	442							
Q8NCL8	reviewed	TM116_HUMAN	Transmembrane protein 116	TMEM116	Homo sapiens (Human)	245				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NCQ2	reviewed	CNAS1_HUMAN	Uncharacterized protein CSNK1G2-AS1 (CSNK1G2 antisense RNA 1) (CSNK1G2 antisense gene protein 1)	CSNK1G2-AS1 C19orf34	Homo sapiens (Human)	148							
Q8NCQ3	reviewed	NC301_HUMAN	Putative uncharacterized protein encoded by LINC00301	LINC00301 C11orf64 NCRNA00301	Homo sapiens (Human)	95				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8NCS4	reviewed	TM35B_HUMAN	Transmembrane protein 35B (ZMYM6 neighbor protein)	TMEM35B ZMYM6NB	Homo sapiens (Human)	154				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8NCU4	reviewed	CC191_HUMAN	Coiled-coil domain-containing protein 191	CCDC191 KIAA1407	Homo sapiens (Human)	936					phosphatase binding [GO:0019902]	phosphatase binding [GO:0019902]	
Q8ND24	reviewed	RN214_HUMAN	RING finger protein 214	RNF214	Homo sapiens (Human)	703					metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]	metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]	
Q8ND94	reviewed	LRN4L_HUMAN	LRRN4 C-terminal-like protein	LRRN4CL UNQ728/PRO1410	Homo sapiens (Human)	238				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q8NDY4	reviewed	MDS2_HUMAN	Myelodysplastic syndrome 2 translocation-associated protein	MDS2	Homo sapiens (Human)	140				extracellular space [GO:0005615]		extracellular space [GO:0005615]	
Q8NDY8	reviewed	TMM52_HUMAN	Transmembrane protein 52	TMEM52 UNQ3048/PRO9864	Homo sapiens (Human)	209				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8NEA4	reviewed	FBX36_HUMAN	F-box only protein 36	FBXO36 FBX36	Homo sapiens (Human)	188	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.						
Q8NEE0	reviewed	KLAS1_HUMAN	Putative uncharacterized protein KLHL30-AS1 (KLHL30 antisense RNA 1)	KLHL30-AS1 C2orf19	Homo sapiens (Human)	82							
Q8NEE8	reviewed	TTC16_HUMAN	Tetratricopeptide repeat protein 16 (TPR repeat protein 16)	TTC16	Homo sapiens (Human)	873							
Q8NEG2	reviewed	CG057_HUMAN	Uncharacterized protein C7orf57	C7orf57	Homo sapiens (Human)	295							
Q8NEL0	reviewed	CCD54_HUMAN	Coiled-coil domain-containing protein 54 (Testis development protein NYD-SP17)	CCDC54	Homo sapiens (Human)	328							
Q8NEQ5	reviewed	CA162_HUMAN	Transmembrane protein C1orf162	C1orf162	Homo sapiens (Human)	155				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8NET4	reviewed	RTL9_HUMAN	Retrotransposon Gag-like protein 9 (Retrotransposon gag domain-containing protein 1) (Tumor antigen BJ-HCC-23)	RTL9 KIAA1318 RGAG1	Homo sapiens (Human)	1388		MISCELLANEOUS: RTL9 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. {ECO:0000269|PubMed:16093683}.					
Q8NEX5	reviewed	WFDC9_HUMAN	Protein WFDC9	WFDC9 WAP9	Homo sapiens (Human)	89		MISCELLANEOUS: Although this protein was isolated in a region containing several WAP proteins and was defined as a WAP protein, it does not contain a classical WAP domain.	antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8NEX6	reviewed	WFD11_HUMAN	Protein WFDC11	WFDC11 WAP11	Homo sapiens (Human)	87		MISCELLANEOUS: Although this protein was isolated in a region containing several WAP proteins and was defined as a WAP protein, it does not contain a classical WAP domain.	antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8NF67	reviewed	A2012_HUMAN	Putative ankyrin repeat domain-containing protein 20A12 pseudogene	ANKRD20A12P	Homo sapiens (Human)	263							
Q8NFP0	reviewed	PXT1_HUMAN	Peroxisomal testis-specific protein 1 (Small testis-specific peroxisomal protein)	PXT1 STEPP	Homo sapiens (Human)	134			positive regulation of apoptotic process [GO:0043065]	nucleus [GO:0005634]; peroxisome [GO:0005777]		nucleus [GO:0005634]; peroxisome [GO:0005777]; positive regulation of apoptotic process [GO:0043065]	SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
Q8NFV5	reviewed	SPDE1_HUMAN	Speedy protein E1 (Williams-Beuren syndrome chromosomal region 19 protein)	SPDYE1 WBSCR19	Homo sapiens (Human)	336					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
Q8NH21	reviewed	OR4F5_HUMAN	Olfactory receptor 4F5	OR4F5	Homo sapiens (Human)	305	FUNCTION: Odorant receptor. {ECO:0000305}.			plasma membrane [GO:0005886]	G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]	SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Q8NHX4	reviewed	SPTA3_HUMAN	Spermatogenesis-associated protein 3 (Testis and spermatogenesis cell-related protein 1) (Testis spermatocyte apoptosis-related protein 1)	SPATA3 TSARG1	Homo sapiens (Human)	192							
Q8NI28	reviewed	R32DT_HUMAN	Putative transmembrane protein RNF32-DT (RNF32 divergent transcript)	RNF32-DT C7orf13 LINC01006 MY040	Homo sapiens (Human)	216				cytoplasm [GO:0005737]; membrane [GO:0016020]		cytoplasm [GO:0005737]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11890671}. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q8TAC1	reviewed	RFESD_HUMAN	Rieske domain-containing protein	RFESD	Homo sapiens (Human)	157					2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]	2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]	
Q8TAD7	reviewed	OCC1_HUMAN	Overexpressed in colon carcinoma 1 protein (OCC-1) (AGD3)	OCC1 C12orf75	Homo sapiens (Human)	63							
Q8TAF5	reviewed	LQK1_HUMAN	Putative uncharacterized protein LQK1 (FLVCR1 antisense RNA 1) (FLVCR1 divergent transcript)	FLVCR1-DT FLVCR1-AS1 LQK1	Homo sapiens (Human)	88							
Q8TAL5	reviewed	CI043_HUMAN	Uncharacterized protein C9orf43	C9orf43	Homo sapiens (Human)	461							
Q8TAY7	reviewed	F110D_HUMAN	Protein FAM110D	FAM110D GRRP1	Homo sapiens (Human)	271							
Q8TB05	reviewed	UBAD1_HUMAN	UBA-like domain-containing protein 1	UBALD1 FAM100A PP11303	Homo sapiens (Human)	177							
Q8TBR4	reviewed	ST3L4_HUMAN	Putative STAG3-like protein 4 (Stromal antigen 3-like protein 4)	STAG3L4	Homo sapiens (Human)	150							
Q8TBR5	reviewed	CSAS1_HUMAN	Putative uncharacterized protein CIRBP-AS1 (CIRBP antisense RNA 1) (CIRBP antisense gene protein 1)	CIRBP-AS1 C19orf23	Homo sapiens (Human)	109							
Q8TBZ9	reviewed	TEX47_HUMAN	Testis-expressed protein 47	TEX47 C7orf62	Homo sapiens (Human)	253							
Q8TC99	reviewed	FNDC8_HUMAN	Fibronectin type III domain-containing protein 8	FNDC8	Homo sapiens (Human)	324				nucleus [GO:0005634]		nucleus [GO:0005634]	
Q8TCA0	reviewed	LRC20_HUMAN	Leucine-rich repeat-containing protein 20	LRRC20 UNQ2429/PRO4989	Homo sapiens (Human)	184							
Q8TCZ7	reviewed	CU074_HUMAN	Putative uncharacterized protein encoded by LINC00308	LINC00308 C21orf74 NCRNA00308 PRED16	Homo sapiens (Human)	52							
Q8TD33	reviewed	SG1C1_HUMAN	Secretoglobin family 1C member 1 (Secretoglobin RYD5)	SCGB1C1	Homo sapiens (Human)	95				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Q8TD35	reviewed	LKAM1_HUMAN	Protein LKAAEAR1 (LKAAEAR motif-containing protein 1)	LKAAEAR1 C20orf201	Homo sapiens (Human)	194							
Q8TD47	reviewed	RS4Y2_HUMAN	Small ribosomal subunit protein eS4, Y isoform 2 (40S ribosomal protein S4, Y isoform 2)	RPS4Y2 RPS4Y2P	Homo sapiens (Human)	263			translation [GO:0006412]	cytosolic small ribosomal subunit [GO:0022627]	RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytosolic small ribosomal subunit [GO:0022627]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]	
Q8TD90	reviewed	MAGE2_HUMAN	Melanoma-associated antigen E2 (Hepatocellular carcinoma-associated protein 3) (MAGE-E2 antigen)	MAGEE2 HCA3	Homo sapiens (Human)	523			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
Q8TDY3	reviewed	ACTT2_HUMAN	Actin-related protein T2 (ARP-T2) (Actin-related protein M2)	ACTRT2 ARPM2	Homo sapiens (Human)	377				cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Q8TE82	reviewed	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeat-containing protein 1	SH3TC1	Homo sapiens (Human)	1336							
Q8TEF2	reviewed	CJ105_HUMAN	Uncharacterized protein C10orf105	C10orf105	Homo sapiens (Human)	133				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8WTQ4	reviewed	CP078_HUMAN	Uncharacterized protein C16orf78	C16orf78	Homo sapiens (Human)	265				nucleus [GO:0005634]		nucleus [GO:0005634]	
Q8WTZ4	reviewed	CA5BL_HUMAN	Putative inactive carbonic anhydrase 5B-like protein (CA-VB-like protein)	CA5BP1 CA5B CA5BL	Homo sapiens (Human)	195			one-carbon metabolic process [GO:0006730]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	carbonate dehydratase activity [GO:0004089]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; carbonate dehydratase activity [GO:0004089]; one-carbon metabolic process [GO:0006730]	
Q8WU43	reviewed	CB015_HUMAN	Uncharacterized protein C2orf15	C2orf15	Homo sapiens (Human)	91					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q8WUB2	reviewed	F216A_HUMAN	Protein FAM216A	FAM216A C12orf24	Homo sapiens (Human)	273							
Q8WUD4	reviewed	CCD12_HUMAN	Coiled-coil domain-containing protein 12	CCDC12	Homo sapiens (Human)	166				nucleoplasm [GO:0005654]; post-mRNA release spliceosomal complex [GO:0071014]; U2-type spliceosomal complex [GO:0005684]		nucleoplasm [GO:0005654]; post-mRNA release spliceosomal complex [GO:0071014]; U2-type spliceosomal complex [GO:0005684]	
Q8WUR7	reviewed	CO040_HUMAN	UPF0235 protein C15orf40	C15orf40	Homo sapiens (Human)	153				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q8WUY1	reviewed	THEM6_HUMAN	Protein THEM6 (Mesenchymal stem cell protein DSCD75) (Thioesterase superfamily member 6)	THEM6 C8orf55 PSEC0098	Homo sapiens (Human)	208				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8WVF5	reviewed	KCTD4_HUMAN	BTB/POZ domain-containing protein KCTD4	KCTD4	Homo sapiens (Human)	259			protein homooligomerization [GO:0051260]			protein homooligomerization [GO:0051260]	
Q8WW59	reviewed	SPRY4_HUMAN	SPRY domain-containing protein 4	SPRYD4	Homo sapiens (Human)	207				nucleus [GO:0005634]		nucleus [GO:0005634]	
Q8WWF6	reviewed	DNJB3_HUMAN	DnaJ homolog subfamily B member 3	DNAJB3 HCG3	Homo sapiens (Human)	145	FUNCTION: May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins. {ECO:0000305}.		chaperone-mediated protein folding [GO:0061077]		Hsp70 protein binding [GO:0030544]; unfolded protein binding [GO:0051082]	Hsp70 protein binding [GO:0030544]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]	
Q8WWF8	reviewed	CAPSL_HUMAN	Calcyphosin-like protein	CAPSL	Homo sapiens (Human)	208				cytoplasm [GO:0005737]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q8WWM1	reviewed	XAGE5_HUMAN	X antigen family member 5 (XAGE-5) (Cancer/testis antigen 12.5) (CT12.5) (G antigen family D member 5)	XAGE5 GAGED5	Homo sapiens (Human)	108							
Q8WWR9	reviewed	PDPFL_HUMAN	Pancreatic progenitor cell differentiation and proliferation factor-like protein (Exocrine differentiation and proliferation factor-like protein)	PPDPFL C8orf22	Homo sapiens (Human)	84			cell differentiation [GO:0030154]			cell differentiation [GO:0030154]	
Q8WZA9	reviewed	IRGQ_HUMAN	Immunity-related GTPase family Q protein	IRGQ IRGQ1 FKSG27	Homo sapiens (Human)	623					GTP binding [GO:0005525]	GTP binding [GO:0005525]	
Q8WZB0	reviewed	CI130_HUMAN	Putative uncharacterized protein ERCC6L2-AS1 (ERCC6L2 antisense RNA 1) (Nasopharyngeal carcinoma-associated gene 12 protein)	ERCC6L2-AS1 C9orf130 LINC00476 NAG12	Homo sapiens (Human)	136							
Q92623	reviewed	TTC9A_HUMAN	Tetratricopeptide repeat protein 9A (TPR repeat protein 9A)	TTC9 KIAA0227 TTC9A	Homo sapiens (Human)	222			bone development [GO:0060348]			bone development [GO:0060348]	
Q92628	reviewed	K0232_HUMAN	Uncharacterized protein KIAA0232	KIAA0232	Homo sapiens (Human)	1395					ATP binding [GO:0005524]	ATP binding [GO:0005524]	
Q969E4	reviewed	TCAL3_HUMAN	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3)	TCEAL3 MSTP072	Homo sapiens (Human)	200	FUNCTION: May be involved in transcriptional regulation.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q969H9	reviewed	DIRC1_HUMAN	Disrupted in renal carcinoma protein 1 (Disrupted in renal cancer protein)	DIRC1	Homo sapiens (Human)	104							
Q96A19	reviewed	C102A_HUMAN	Coiled-coil domain-containing protein 102A	CCDC102A	Homo sapiens (Human)	550				myosin complex [GO:0016459]		myosin complex [GO:0016459]	
Q96A22	reviewed	CK052_HUMAN	Uncharacterized protein C11orf52	C11orf52	Homo sapiens (Human)	123				extracellular exosome [GO:0070062]		extracellular exosome [GO:0070062]	
Q96AQ1	reviewed	CC74A_HUMAN	Coiled-coil domain-containing protein 74A	CCDC74A	Homo sapiens (Human)	378							
Q96AQ2	reviewed	TM125_HUMAN	Transmembrane protein 125	TMEM125	Homo sapiens (Human)	219				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96AT1	reviewed	K1143_HUMAN	Uncharacterized protein KIAA1143	KIAA1143	Homo sapiens (Human)	154							
Q96B54	reviewed	ZN428_HUMAN	Zinc finger protein 428 (Enzyme-like protein PIT13)	ZNF428 C19orf37	Homo sapiens (Human)	188					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q96B70	reviewed	LENG9_HUMAN	Leukocyte receptor cluster member 9	LENG9	Homo sapiens (Human)	501					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q96CN7	reviewed	ISOC1_HUMAN	Isochorismatase domain-containing protein 1	ISOC1 CGI-111	Homo sapiens (Human)	298				cytoplasm [GO:0005737]; peroxisome [GO:0005777]		cytoplasm [GO:0005737]; peroxisome [GO:0005777]	
Q96CP2	reviewed	FWCH2_HUMAN	FLYWCH family member 2	FLYWCH2	Homo sapiens (Human)	140					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q96CX6	reviewed	LRC58_HUMAN	Leucine-rich repeat-containing protein 58	LRRC58	Homo sapiens (Human)	371			signal transduction [GO:0007165]			signal transduction [GO:0007165]	
Q96D70	reviewed	R3HD4_HUMAN	R3H domain-containing protein 4	R3HDM4 C19orf22	Homo sapiens (Human)	268				nucleus [GO:0005634]	nucleic acid binding [GO:0003676]	nucleus [GO:0005634]; nucleic acid binding [GO:0003676]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96DE9	reviewed	EOLA2_HUMAN	Protein EOLA2 (Protein CXorf40B)	EOLA2 CXorf40B	Homo sapiens (Human)	158							
Q96DM1	reviewed	PGBD4_HUMAN	PiggyBac transposable element-derived protein 4	PGBD4	Homo sapiens (Human)	585							
Q96EE4	reviewed	CC126_HUMAN	Coiled-coil domain-containing protein 126	CCDC126 UNQ786/PRO1605	Homo sapiens (Human)	140				extracellular region [GO:0005576]; membrane [GO:0016020]		extracellular region [GO:0005576]; membrane [GO:0016020]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96EK9	reviewed	KTI12_HUMAN	Protein KTI12 homolog	KTI12 SBBI81	Homo sapiens (Human)	354			tRNA wobble uridine modification [GO:0002098]		ATP binding [GO:0005524]	ATP binding [GO:0005524]; tRNA wobble uridine modification [GO:0002098]	
Q96EX1	reviewed	SIM12_HUMAN	Small integral membrane protein 12	SMIM12 C1orf212	Homo sapiens (Human)	92				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96F83	reviewed	CLBA1_HUMAN	Uncharacterized protein CLBA1 (Clathrin-binding box of aftiphilin-containing protein 1)	CLBA1 C14orf79	Homo sapiens (Human)	325			intracellular transport [GO:0046907]	AP-1 adaptor complex [GO:0030121]; trans-Golgi network membrane [GO:0032588]	clathrin binding [GO:0030276]	AP-1 adaptor complex [GO:0030121]; trans-Golgi network membrane [GO:0032588]; clathrin binding [GO:0030276]; intracellular transport [GO:0046907]	
Q96FA7	reviewed	ZB10P_HUMAN	Putative protein ZBED10P (ZBED6 C-terminal-like protein) (zinc finger BED-type containing 10 pseudogene)	ZBED10P C7orf29 ZBED6CL	Homo sapiens (Human)	236							
Q96FF7	reviewed	MISP3_HUMAN	Uncharacterized protein MISP3 (MISP family member 3)	MISP3	Homo sapiens (Human)	219							
Q96FK6	reviewed	WDR89_HUMAN	WD repeat-containing protein 89	WDR89 C14orf150 MSTP050	Homo sapiens (Human)	387			corpus callosum development [GO:0022038]; ventricular system development [GO:0021591]			corpus callosum development [GO:0022038]; ventricular system development [GO:0021591]	
Q96FQ7	reviewed	CR018_HUMAN	Putative uncharacterized protein encoded by LINC00526	LINC00526 C18orf18	Homo sapiens (Human)	95							
Q96FV0	reviewed	LRC46_HUMAN	Leucine-rich repeat-containing protein 46	LRRC46	Homo sapiens (Human)	321							
Q96GI7	reviewed	FA89A_HUMAN	Protein FAM89A	FAM89A C1orf153	Homo sapiens (Human)	184							
Q96H35	reviewed	RBM18_HUMAN	Probable RNA-binding protein 18 (RNA-binding motif protein 18)	RBM18	Homo sapiens (Human)	190				cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]	
Q96HG1	reviewed	SIM10_HUMAN	Small integral membrane protein 10	SMIM10 CXorf69	Homo sapiens (Human)	83				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q96HH4	reviewed	TM169_HUMAN	Transmembrane protein 169	TMEM169	Homo sapiens (Human)	297				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96HM7	reviewed	PED1B_HUMAN	PC-esterase domain-containing protein 1B (Protein FAM113B)	PCED1B FAM113B	Homo sapiens (Human)	432							
Q96HZ7	reviewed	URAS1_HUMAN	Putative uncharacterized protein URB1-AS1 (URB1 antisense RNA 1) (URB1 antisense gene protein 1)	URB1-AS1 C21orf119 PRED84	Homo sapiens (Human)	61							
Q96I45	reviewed	TM141_HUMAN	Transmembrane protein 141	TMEM141	Homo sapiens (Human)	108				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96IM9	reviewed	DYDC2_HUMAN	DPY30 domain-containing protein 2	DYDC2	Homo sapiens (Human)	177				Set1C/COMPASS complex [GO:0048188]		Set1C/COMPASS complex [GO:0048188]	
Q96IR2	reviewed	ZN845_HUMAN	Zinc finger protein 845	ZNF845	Homo sapiens (Human)	970	FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.		regulation of transcription by RNA polymerase II [GO:0006357]	nucleus [GO:0005634]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; regulation of transcription by RNA polymerase II [GO:0006357]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96IW2	reviewed	SHD_HUMAN	SH2 domain-containing adapter protein D	SHD	Homo sapiens (Human)	340	FUNCTION: May function as an adapter protein. {ECO:0000250}.				phosphotyrosine residue binding [GO:0001784]	phosphotyrosine residue binding [GO:0001784]	
Q96K31	reviewed	CH076_HUMAN	Uncharacterized protein C8orf76	C8orf76	Homo sapiens (Human)	380							
Q96KF7	reviewed	SMIM8_HUMAN	Small integral membrane protein 8	SMIM8 C6orf162 DC18	Homo sapiens (Human)	97				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96KW2	reviewed	P12L2_HUMAN	POM121-like protein 2	POM121L2 POM121L	Homo sapiens (Human)	1035			protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]	nuclear pore [GO:0005643]	nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]	nuclear pore [GO:0005643]; nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]	
Q96LI9	reviewed	CX058_HUMAN	Uncharacterized protein CXorf58	CXorf58	Homo sapiens (Human)	332							
Q96LM9	reviewed	CT173_HUMAN	Uncharacterized protein C20orf173	C20orf173	Homo sapiens (Human)	149			ganglioside biosynthetic process via lactosylceramide [GO:0010706]; protein glycosylation [GO:0006486]; sialylation [GO:0097503]	membrane [GO:0016020]	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]	membrane [GO:0016020]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; ganglioside biosynthetic process via lactosylceramide [GO:0010706]; protein glycosylation [GO:0006486]; sialylation [GO:0097503]	
Q96LP6	reviewed	CL042_HUMAN	Uncharacterized protein C12orf42	C12orf42	Homo sapiens (Human)	360		MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q96LR7	reviewed	CB050_HUMAN	Uncharacterized protein C2orf50	C2orf50	Homo sapiens (Human)	162							
Q96LS8	reviewed	CB048_HUMAN	Putative uncharacterized protein C2orf48	C2orf48	Homo sapiens (Human)	159							
Q96LZ2	reviewed	MAGBA_HUMAN	Melanoma-associated antigen B10 (MAGE-B10 antigen)	MAGEB10	Homo sapiens (Human)	347			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
Q96M19	reviewed	CL067_HUMAN	Putative transmembrane protein encoded by LINC00477	LINC00477 C12orf67	Homo sapiens (Human)	166				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q96M43	reviewed	NBPF4_HUMAN	Neuroblastoma breakpoint family member 4	NBPF4	Homo sapiens (Human)	638		MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.		cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Q96M60	reviewed	F227B_HUMAN	Protein FAM227B	FAM227B C15orf33	Homo sapiens (Human)	508							
Q96MC4	reviewed	C295L_HUMAN	CEP295 N-terminal-like protein (KIAA1731 N-terminal like protein)	CEP295NL KIAA1731NL	Homo sapiens (Human)	621			regulation of centriole replication [GO:0046599]	centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]	microtubule binding [GO:0008017]	centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule binding [GO:0008017]; regulation of centriole replication [GO:0046599]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}. Note=Colocalizes to the motile cilium of mature spermatozoa. {ECO:0000250}.
Q96MC9	reviewed	CA147_HUMAN	Putative uncharacterized protein IKBKE-AS1 (IKBKE antisense RNA 1) (Uncharacterized protein C1orf147)	IKBKE-AS1 C1orf147	Homo sapiens (Human)	270							
Q96MD7	reviewed	CI085_HUMAN	Uncharacterized protein C9orf85	C9orf85	Homo sapiens (Human)	179		MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.					
Q96MP5	reviewed	ZSWM3_HUMAN	Zinc finger SWIM domain-containing protein 3	ZSWIM3 C20orf164	Homo sapiens (Human)	696					zinc ion binding [GO:0008270]	zinc ion binding [GO:0008270]	
Q96MR7	reviewed	OBAS1_HUMAN	Putative uncharacterized protein OBSCN-AS1 (OBSCN antisense RNA 1) (OBSCN antisense gene protein 1)	OBSCN-AS1 C1orf145	Homo sapiens (Human)	158		MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.					
Q96MU5	reviewed	CQ077_HUMAN	Uncharacterized protein CD300LD-AS1 (CD300LD antisense RNA 1)	CD300LD-AS1 C17orf77	Homo sapiens (Human)	243				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q96MW7	reviewed	TIGD1_HUMAN	Tigger transposable element-derived protein 1	TIGD1	Homo sapiens (Human)	591				nucleus [GO:0005634]	DNA binding [GO:0003677]	nucleus [GO:0005634]; DNA binding [GO:0003677]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q96MZ0	reviewed	GD1L1_HUMAN	Ganglioside-induced differentiation-associated protein 1-like 1 (GDAP1-L1)	GDAP1L1	Homo sapiens (Human)	367				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q96MZ4	reviewed	F218A_HUMAN	Protein FAM218A	FAM218A C4orf39	Homo sapiens (Human)	157							
Q96N35	reviewed	TMM83_HUMAN	Putative uncharacterized protein encoded by LINC00052 (Putative transmembrane protein 83)	LINC00052 NCRNA00052 TMEM83	Homo sapiens (Human)	136				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96N53	reviewed	CK037_HUMAN	Putative uncharacterized protein encoded by LINC00167 (PRDM10-DT divergent transcript)	PRDM10-DT C11orf37 LINC00167 NCRNA00167	Homo sapiens (Human)	147							
Q96NR7	reviewed	WWAS2_HUMAN	Putative uncharacterized protein WWC2-AS2 (WWC2 antisense RNA 2) (WWC2 antisense gene protein 2)	WWC2-AS2 C4orf38	Homo sapiens (Human)	200							
Q96NS1	reviewed	YPEL4_HUMAN	Protein yippee-like 4	YPEL4	Homo sapiens (Human)	127				nucleolus [GO:0005730]	metal ion binding [GO:0046872]	nucleolus [GO:0005730]; metal ion binding [GO:0046872]	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15556292}.
Q96NS8	reviewed	CLUP3_HUMAN	Putative protein CLUHP3 (Clustered mitochondria (cluA/CLU1) homolog pseudogene 3) (KIAA0664-like protein 3)	CLUHP3 C16orf67 KIAA0664L3	Homo sapiens (Human)	147							
Q96PG1	reviewed	M4A4E_HUMAN	Putative membrane-spanning 4-domains subfamily A member 4E	MS4A4E	Homo sapiens (Human)	132				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Q96PP4	reviewed	TSG13_HUMAN	Testis-specific gene 13 protein	TSGA13	Homo sapiens (Human)	275							
Q96PQ5	reviewed	IPP2L_HUMAN	Putative protein phosphatase inhibitor 2-like protein 1 (Protein phosphatase 1, regulatory subunit 2 pseudogene 1)	PPP1R2P1	Homo sapiens (Human)	205	FUNCTION: Inhibitor of protein-phosphatase 1. {ECO:0000250}.		glycogen metabolic process [GO:0005977]; regulation of signal transduction [GO:0009966]		protein phosphatase inhibitor activity [GO:0004864]	protein phosphatase inhibitor activity [GO:0004864]; glycogen metabolic process [GO:0005977]; regulation of signal transduction [GO:0009966]	
Q96PY0	reviewed	K1908_HUMAN	Putative uncharacterized protein PSMG3-AS1 (PSMG3 antisense RNA 1)	PSMG3-AS1 KIAA1908	Homo sapiens (Human)	264							
Q96QU4	reviewed	FRG2B_HUMAN	Protein FRG2-like-1 (FSHD region gene 2 protein family member B) (HSA10-FRG2)	FRG2B	Homo sapiens (Human)	278				nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
Q96S07	reviewed	PRR25_HUMAN	Proline-rich protein 25	PRR25 gs64	Homo sapiens (Human)	402							
Q99440	reviewed	CD006_HUMAN	Uncharacterized protein encoded by LINC01587 (Protein AC1)	LINC01587 AC1 C4orf6	Homo sapiens (Human)	93			nervous system development [GO:0007399]			nervous system development [GO:0007399]	
Q9BPW8	reviewed	NIPS1_HUMAN	Protein NipSnap homolog 1 (NipSnap1)	NIPSNAP1	Homo sapiens (Human)	284			sensory perception of pain [GO:0019233]	mitochondrion [GO:0005739]; synaptic membrane [GO:0097060]	neurotransmitter binding [GO:0042165]	mitochondrion [GO:0005739]; synaptic membrane [GO:0097060]; neurotransmitter binding [GO:0042165]; sensory perception of pain [GO:0019233]	
Q9BPX7	reviewed	CG025_HUMAN	UPF0415 protein C7orf25	C7orf25	Homo sapiens (Human)	421							
Q9BQ49	reviewed	SMIM7_HUMAN	Small integral membrane protein 7	SMIM7 C19orf42	Homo sapiens (Human)	75				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9BQM9	reviewed	CT144_HUMAN	Uncharacterized protein C20orf144 (Bcl-2-like protein from testis) (Bclt)	C20orf144	Homo sapiens (Human)	153							
Q9BR11	reviewed	ZSWM1_HUMAN	Zinc finger SWIM domain-containing protein 1	ZSWIM1 C20orf162	Homo sapiens (Human)	485				nucleus [GO:0005634]	zinc ion binding [GO:0008270]	nucleus [GO:0005634]; zinc ion binding [GO:0008270]	
Q9BR46	reviewed	SCAS1_HUMAN	Putative uncharacterized protein SCP2D1-AS1 (SCP2D1 antisense RNA 1)	SCP2D1-AS1 C20orf78	Homo sapiens (Human)	151							
Q9BRJ6	reviewed	CG050_HUMAN	Uncharacterized protein C7orf50	C7orf50 FP15621	Homo sapiens (Human)	194					RNA binding [GO:0003723]	RNA binding [GO:0003723]	
Q9BRP1	reviewed	PDD2L_HUMAN	Programmed cell death protein 2-like	PDCD2L	Homo sapiens (Human)	358	FUNCTION: Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. {ECO:0000269|PubMed:17393540}.		apoptotic process [GO:0006915]; cell cycle [GO:0007049]	cytoplasm [GO:0005737]; membrane [GO:0016020]		cytoplasm [GO:0005737]; membrane [GO:0016020]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]	
Q9BS92	reviewed	NPS3B_HUMAN	Protein NipSnap homolog 3B (NipSnap3B) (SNAP1)	NIPSNAP3B NIPSNAP3	Homo sapiens (Human)	247				mitochondrion [GO:0005739]		mitochondrion [GO:0005739]	
Q9BTA0	reviewed	F167B_HUMAN	Protein FAM167B	FAM167B C1orf90	Homo sapiens (Human)	163							
Q9BTX7	reviewed	TTPAL_HUMAN	Alpha-tocopherol transfer protein-like	TTPAL C20orf121	Homo sapiens (Human)	342	FUNCTION: May act as a protein that binds a hydrophobic ligand. {ECO:0000305}.			membrane [GO:0016020]	phosphatidylinositol bisphosphate binding [GO:1902936]	membrane [GO:0016020]; phosphatidylinositol bisphosphate binding [GO:1902936]	
Q9BU68	reviewed	PR15L_HUMAN	Proline-rich protein 15-like protein (Protein ATAD4)	PRR15L ATAD4	Homo sapiens (Human)	103							
Q9BVG4	reviewed	PBDC1_HUMAN	Protein PBDC1 (Polysaccharide biosynthesis domain-containing protein 1)	PBDC1 CXorf26	Homo sapiens (Human)	233							
Q9BVR0	reviewed	HRC23_HUMAN	Putative HERC2-like protein 3	HERC2P3	Homo sapiens (Human)	1158			protein ubiquitination [GO:0016567]		metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]	
Q9BVW6	reviewed	SMIM2_HUMAN	Small integral membrane protein 2	SMIM2 C13orf44	Homo sapiens (Human)	85				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9BWJ2	reviewed	RHAS1_HUMAN	Putative uncharacterized protein encoded by RHPN1-AS1 (RHPN1 antisense RNA 1) (RHPN1 antisense gene protein 1)	RHPN1-AS1 C8orf51	Homo sapiens (Human)	59							
Q9BX51	reviewed	GGTL1_HUMAN	Glutathione hydrolase light chain 1 (Gamma-glutamyltransferase light chain 1) (Gamma-glutamyltransferase-like activity 4) (Gamma-glutamyltransferase-like protein 6)	GGTLC1 GGTLA4	Homo sapiens (Human)	225		MISCELLANEOUS: Corresponds to the light chain of other gamma-glutamyltransferase family members. Has no catalytic activity.	glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]		glutathione hydrolase activity [GO:0036374]	glutathione hydrolase activity [GO:0036374]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]	
Q9BXJ2	reviewed	C1QT7_HUMAN	Complement C1q tumor necrosis factor-related protein 7	C1QTNF7 CTRP7	Homo sapiens (Human)	289				collagen trimer [GO:0005581]; extracellular region [GO:0005576]		collagen trimer [GO:0005581]; extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9BXQ6	reviewed	T121B_HUMAN	Transmembrane protein 121B (Cat eye syndrome critical region protein 6)	TMEM121B CECR6	Homo sapiens (Human)	578		MISCELLANEOUS: Candidate gene for the Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. Duplication usually takes in the form of a surpernumerary bisatellited isodicentric chromosome, resulting in four copies of the region (represents an inv dup(22)(q11)). CES is characterized clinically by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development. {ECO:0000305|PubMed:11381032}.					
Q9BXU2	reviewed	TX13B_HUMAN	Testis-expressed protein 13B	TEX13B	Homo sapiens (Human)	312					mRNA binding [GO:0003729]	mRNA binding [GO:0003729]	
Q9BY89	reviewed	K1671_HUMAN	Uncharacterized protein KIAA1671	KIAA1671	Homo sapiens (Human)	1806		MISCELLANEOUS: Antibodies against KIAA1671 are present in sera from patients with breast cancer who developed several autoantibodies.					
Q9BYD9	reviewed	ACTT3_HUMAN	Actin-related protein T3 (ARP-T3) (Actin-related protein M1)	ACTRT3 ARPM1	Homo sapiens (Human)	372				cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; male germ cell nucleus [GO:0001673]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; male germ cell nucleus [GO:0001673]	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Q9BYL1	reviewed	SAM10_HUMAN	Sterile alpha motif domain-containing protein 10 (SAM domain-containing protein 10)	SAMD10 C20orf136	Homo sapiens (Human)	202			transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	cytoplasmic side of plasma membrane [GO:0009898]		cytoplasmic side of plasma membrane [GO:0009898]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	
Q9BYS8	reviewed	LRRC2_HUMAN	Leucine-rich repeat-containing protein 2	LRRC2	Homo sapiens (Human)	371			signal transduction [GO:0007165]			signal transduction [GO:0007165]	
Q9BZ19	reviewed	ANR60_HUMAN	Ankyrin repeat domain-containing protein 60	ANKRD60 C20orf86	Homo sapiens (Human)	345							
Q9BZ68	reviewed	FR8P1_HUMAN	Putative FERM domain-containing protein FRMD8P1 (FERM domain-containing 8 pseudogene 1)	FRMD8P1 FKSG43	Homo sapiens (Human)	369			negative regulation of canonical Wnt signaling pathway [GO:0090090]	cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]		cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; negative regulation of canonical Wnt signaling pathway [GO:0090090]	
Q9BZ81	reviewed	MAGB5_HUMAN	Melanoma-associated antigen B5 (Cancer/testis antigen 3.3) (CT3.3) (MAGE-B5 antigen)	MAGEB5	Homo sapiens (Human)	275			negative regulation of transcription by RNA polymerase II [GO:0000122]	nucleus [GO:0005634]		nucleus [GO:0005634]; negative regulation of transcription by RNA polymerase II [GO:0000122]	
Q9BZ97	reviewed	TTY13_HUMAN	Putative transcript Y 13 protein	TTTY13 TTY13	Homo sapiens (Human)	58				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Q9BZA5	reviewed	TXNG2_HUMAN	Putative gamma-taxilin 2 (Gamma-taxilin 2 pseudogene) (Taxilin gamma pseudogene, Y-linked)	TXLNGY CYorf15A CYorf15B TXLNG2P	Homo sapiens (Human)	131					syntaxin binding [GO:0019905]	syntaxin binding [GO:0019905]	
Q9BZE7	reviewed	EVG1_HUMAN	UPF0193 protein EVG1	C22orf23	Homo sapiens (Human)	217							
Q9BZP3	reviewed	CR002_HUMAN	Putative uncharacterized protein encoded by LINC00470	LINC00470 C18orf2	Homo sapiens (Human)	86							
Q9C002	reviewed	NMES1_HUMAN	Normal mucosa of esophagus-specific gene 1 protein (Protein FOAP-11)	NMES1 C15orf48	Homo sapiens (Human)	83			response to bacterium [GO:0009617]	mitochondrial respiratory chain complex IV [GO:0005751]; nucleus [GO:0005634]		mitochondrial respiratory chain complex IV [GO:0005751]; nucleus [GO:0005634]; response to bacterium [GO:0009617]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12209954}.
Q9C073	reviewed	F117A_HUMAN	Protein FAM117A (C/EBP-induced protein)	FAM117A	Homo sapiens (Human)	453							
Q9GZL8	reviewed	BPEC1_HUMAN	Putative BPES syndrome breakpoint region protein (BPES candidate 1)	BPESC1	Homo sapiens (Human)	116							
Q9GZU0	reviewed	CF062_HUMAN	Uncharacterized protein C6orf62 (HBV X-transactivated gene 12 protein) (HBV XAg-transactivated protein 12)	C6orf62 XTP12 Nbla00237	Homo sapiens (Human)	229							
Q9H098	reviewed	F107B_HUMAN	Protein FAM107B	FAM107B C10orf45	Homo sapiens (Human)	131							
Q9H0H9	reviewed	C4F30_HUMAN	Putative cytochrome P450 family member 4F30	CYP4F30P C2orf14	Homo sapiens (Human)	118							
Q9H0P7	reviewed	AGIT1_HUMAN	Putative uncharacterized protein encoded by AGPAT4-IT1 (AGPAT4 intronic transcript 1)	AGPAT4-IT1 C6orf59 NCRNA00241	Homo sapiens (Human)	198							
Q9H0Q0	reviewed	CYRIA_HUMAN	CYFIP-related Rac1 interactor A (Protein CYRIA)	CYRIA FAM49A	Homo sapiens (Human)	323	FUNCTION: May negatively regulate RAC1 signaling and RAC1-driven cytoskeletal remodeling (Probable). May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions (Probable). {ECO:0000305|PubMed:30250061}.		regulation of actin filament polymerization [GO:0030833]	membrane [GO:0016020]	small GTPase binding [GO:0031267]	membrane [GO:0016020]; small GTPase binding [GO:0031267]; regulation of actin filament polymerization [GO:0030833]	SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NUQ9}; Lipid-anchor {ECO:0000250|UniProtKB:Q9NUQ9}.
Q9H0W7	reviewed	THAP2_HUMAN	THAP domain-containing protein 2	THAP2	Homo sapiens (Human)	228				nucleolus [GO:0005730]; nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]	
Q9H106	reviewed	SIRPD_HUMAN	Signal-regulatory protein delta (SIRP-delta) (Protein tyrosine phosphatase non-receptor type substrate 1-like 2)	SIRPD PTPNS1L2	Homo sapiens (Human)	197				extracellular region [GO:0005576]; plasma membrane [GO:0005886]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H1F0	reviewed	WF10A_HUMAN	WAP four-disulfide core domain protein 10A (Putative protease inhibitor WAP10A)	WFDC10A C20orf146 WAP10	Homo sapiens (Human)	79			antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	extracellular space [GO:0005615]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H1X3	reviewed	DJC25_HUMAN	DnaJ homolog subfamily C member 25	DNAJC25	Homo sapiens (Human)	360			protein folding [GO:0006457]	endoplasmic reticulum membrane [GO:0005789]		endoplasmic reticulum membrane [GO:0005789]; protein folding [GO:0006457]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9H246	reviewed	CA021_HUMAN	Uncharacterized protein C1orf21 (Cell proliferation-inducing gene 13 protein)	C1orf21 PIG13	Homo sapiens (Human)	121							
Q9H2J1	reviewed	CI037_HUMAN	Uncharacterized protein ARRDC1-AS1 (ARRDC1 antisense RNA 1) (ARRDC1 antisense gene protein 1)	ARRDC1-AS1 C9orf37 AD038	Homo sapiens (Human)	176							
Q9H3Y8	reviewed	PPDPF_HUMAN	Pancreatic progenitor cell differentiation and proliferation factor (Exocrine differentiation and proliferation factor)	PPDPF C20orf149 EXPDF	Homo sapiens (Human)	114	FUNCTION: Probable regulator of exocrine pancreas development. {ECO:0000250}.		cell differentiation [GO:0030154]			cell differentiation [GO:0030154]	
Q9H478	reviewed	KCQ1D_HUMAN	KCNQ1 downstream neighbor protein (Beckwith-Wiedemann region transcript protein)	KCNQ1DN BWRT	Homo sapiens (Human)	68							
Q9H489	reviewed	TSY26_HUMAN	Putative testis-specific Y-encoded-like protein 3 (TSPY-like protein 3) (Testis-specific Y-encoded protein 26 pseudogene)	TSPY26P TSPYL3	Homo sapiens (Human)	355			nucleosome assembly [GO:0006334]	chromatin [GO:0000785]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; histone binding [GO:0042393]	chromatin [GO:0000785]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; nucleosome assembly [GO:0006334]	
Q9H496	reviewed	IFG15_HUMAN	Torsin-1A-interacting protein 2, isoform IFRG15 (15 kDa interferon-responsive protein) (IFRG15)	TOR1AIP2 IFRG15	Homo sapiens (Human)	131		MISCELLANEOUS: [Isoform IFRG15]: Dubious isoform.					
Q9H4G8	reviewed	DPH3B_HUMAN	Putative DPH3 homolog B (CSL-type zinc finger-containing protein 1)	DPH3P1 C20orf143 DPH3B ZCSL1	Homo sapiens (Human)	78					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
Q9H4I3	reviewed	TRABD_HUMAN	TraB domain-containing protein (Protein TTG2)	TRABD TTG2 PP2447	Homo sapiens (Human)	376							
Q9H4R4	reviewed	CT191_HUMAN	Putative nuclear receptor corepressor 1-like protein NCOR1P1 (Nuclear receptor corepressor 1 pseudogene 1)	NCOR1P1 C20orf191	Homo sapiens (Human)	102							
Q9H560	reviewed	ANR19_HUMAN	Putative ankyrin repeat domain-containing protein 19 (Ankyrin repeat domain-containing protein 19 pseudogene)	ANKRD19P ANKRD19	Homo sapiens (Human)	264							
Q9H579	reviewed	MROH8_HUMAN	Protein MROH8 (Maestro heat-like repeat-containing protein family member 8)	MROH8 C20orf131 C20orf132	Homo sapiens (Human)	483							
Q9H606	reviewed	PRORY_HUMAN	Proline-rich protein, Y-linked	PRORY CYorf17	Homo sapiens (Human)	182							
Q9H607	reviewed	OCEL1_HUMAN	Occludin/ELL domain-containing protein 1	OCEL1	Homo sapiens (Human)	264			bicellular tight junction assembly [GO:0070830]	apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]		apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; bicellular tight junction assembly [GO:0070830]	
Q9H6K5	reviewed	PRR36_HUMAN	Proline-rich protein 36	PRR36	Homo sapiens (Human)	1346							
Q9H6N6	reviewed	MYH16_HUMAN	Putative uncharacterized protein MYH16 (Myosin heavy chain 16 pseudogene) (myosin heavy polypeptide 5)	MYH16 MYH5	Homo sapiens (Human)	1097	FUNCTION: Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes. {ECO:0000303|PubMed:15042088}.			myosin complex [GO:0016459]		myosin complex [GO:0016459]	
Q9H7B7	reviewed	CG069_HUMAN	Putative uncharacterized protein PKD1L1-AS1 (PKD1L1 antisense RNA 1)	PKD1L1-AS1 C7orf69	Homo sapiens (Human)	122				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9H7F4	reviewed	T185B_HUMAN	Transmembrane protein 185B (Protein FAM11B)	TMEM185B FAM11B	Homo sapiens (Human)	350				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9H7M6	reviewed	ZSWM4_HUMAN	Zinc finger SWIM domain-containing protein 4	ZSWIM4	Homo sapiens (Human)	989				Cul2-RING ubiquitin ligase complex [GO:0031462]	zinc ion binding [GO:0008270]	Cul2-RING ubiquitin ligase complex [GO:0031462]; zinc ion binding [GO:0008270]	
Q9H8W3	reviewed	F204A_HUMAN	Protein FAM204A	FAM204A C10orf84	Homo sapiens (Human)	233							
Q9H8X3	reviewed	CF208_HUMAN	Putative uncharacterized protein LINC00574	LINC00574 C6orf208	Homo sapiens (Human)	128							
Q9H9A6	reviewed	LRC40_HUMAN	Leucine-rich repeat-containing protein 40	LRRC40	Homo sapiens (Human)	602			signal transduction [GO:0007165]	membrane [GO:0016020]		membrane [GO:0016020]; signal transduction [GO:0007165]	
Q9H9R9	reviewed	DBND1_HUMAN	Dysbindin domain-containing protein 1	DBNDD1	Homo sapiens (Human)	158				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	
Q9HAH7	reviewed	FBRS_HUMAN	Probable fibrosin-1	FBRS FBS FBS1	Homo sapiens (Human)	460							
Q9HAU6	reviewed	TCTP8_HUMAN	Putative translationally-controlled tumor protein-like protein TPT1P8 (Putative apoptosis inhibitor FKSG2)	TPT1P8 FKSG2	Homo sapiens (Human)	139			apoptotic process [GO:0006915]	cytoplasm [GO:0005737]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]; apoptotic process [GO:0006915]	
Q9HBX3	reviewed	SNIT1_HUMAN	Uncharacterized protein encoded by SND1-IT1 (Brain and nasopharyngeal carcinoma susceptibility protein NSG-x) (Nasopharyngeal carcinoma-associated gene 8 protein) (SND1 intronic transcript 1)	SND1-IT1 C7orf54 NAG8	Homo sapiens (Human)	110							
Q9HC47	reviewed	CTGE1_HUMAN	Cutaneous T-cell lymphoma-associated antigen 1 (Protein cTAGE-1) (Cancer/testis antigen 21.1) (CT21.1)	CTAGE1 CTAGE2	Homo sapiens (Human)	74		MISCELLANEOUS: Cancer-testis antigen containing the epitope FVLFLFGGN which is detected in sera of CTCL patients according to PubMed:12839582. Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients. Detected by 5 of 15 sera of Mycosis fungoides patients and by 2 of 3 sera of Sezary syndrome patients, but not by any control sera. Expressed in around 35% of the tested CTCL tumors.		membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9HD87	reviewed	CF050_HUMAN	Putative uncharacterized protein C6orf50 (Nasopharyngeal carcinoma-associated gene 19 protein)	C6orf50 NAG19	Homo sapiens (Human)	102				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NPB0	reviewed	SMDC1_HUMAN	SAYSvFN domain-containing protein 1	SAYSD1 C6orf64	Homo sapiens (Human)	183				cytoplasmic vesicle membrane [GO:0030659]; intracellular membrane-bounded organelle [GO:0043231]		cytoplasmic vesicle membrane [GO:0030659]; intracellular membrane-bounded organelle [GO:0043231]	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:22361696}; Single-pass membrane protein {ECO:0000269|PubMed:22361696}.
Q9NPU4	reviewed	CN132_HUMAN	Uncharacterized protein C14orf132	C14orf132 C14orf88	Homo sapiens (Human)	83				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q9NQ32	reviewed	CK016_HUMAN	Uncharacterized protein C11orf16	C11orf16	Homo sapiens (Human)	467							
Q9NQ39	reviewed	RS10L_HUMAN	Putative ribosomal protein eS10-like (Putative 40S ribosomal protein S10-like)	RPS10P5 RPS10L	Homo sapiens (Human)	176				cytosolic small ribosomal subunit [GO:0022627]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosolic small ribosomal subunit [GO:0022627]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	
Q9NQR7	reviewed	CC177_HUMAN	Coiled-coil domain-containing protein 177 (Myelin proteolipid protein-like protein)	CCDC177 C14orf162 PLPL	Homo sapiens (Human)	707							
Q9NRI6	reviewed	PYY2_HUMAN	Putative peptide YY-2 (Putative peptide YY2)	PYY2	Homo sapiens (Human)	33				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted.
Q9NRJ2	reviewed	GSAS1_HUMAN	Putative uncharacterized protein GSN-AS1 (GSN antisense RNA 1) (GSN antisense gene protein 1) (Protein MOST-2)	GSN-AS1 C9orf31 MOST2	Homo sapiens (Human)	163							
Q9NRP4	reviewed	SDHF3_HUMAN	Succinate dehydrogenase assembly factor 3, mitochondrial (SDH assembly factor 3) (SDHAF3)	SDHAF3 ACN9 DC11	Homo sapiens (Human)	125	FUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. {ECO:0000250|UniProtKB:Q04401, ECO:0000250|UniProtKB:Q8SZ16}.		mitochondrial respiratory chain complex II assembly [GO:0034553]; regulation of gluconeogenesis [GO:0006111]; succinate metabolic process [GO:0006105]	mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]		mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex II assembly [GO:0034553]; regulation of gluconeogenesis [GO:0006111]; succinate metabolic process [GO:0006105]	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q04401}.
Q9NRX3	reviewed	NUA4L_HUMAN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 (NADH-ubiquinone oxidoreductase MLRQ subunit homolog) (NUOMS)	NDUFA4L2	Homo sapiens (Human)	87				mitochondrial respiratory chain complex IV [GO:0005751]		mitochondrial respiratory chain complex IV [GO:0005751]	
Q9NSQ0	reviewed	RRP7B_HUMAN	Putative ribosomal RNA-processing protein 7 homolog B (Putative gastric cancer antigen Zg14-like protein)	RRP7BP RRP7B	Homo sapiens (Human)	103			ribosomal small subunit assembly [GO:0000028]; rRNA processing [GO:0006364]	CURI complex [GO:0032545]; UTP-C complex [GO:0034456]		CURI complex [GO:0032545]; UTP-C complex [GO:0034456]; ribosomal small subunit assembly [GO:0000028]; rRNA processing [GO:0006364]	
Q9NU53	reviewed	GINM1_HUMAN	Glycoprotein integral membrane protein 1	GINM1 C6orf72 UNQ710/PRO1361	Homo sapiens (Human)	330				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Q9NUB4	reviewed	CT141_HUMAN	Uncharacterized protein C20orf141	C20orf141	Homo sapiens (Human)	165				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9NUC0	reviewed	SRTD4_HUMAN	SERTA domain-containing protein 4	SERTAD4	Homo sapiens (Human)	356				nucleus [GO:0005634]		nucleus [GO:0005634]	
Q9NUD7	reviewed	CT096_HUMAN	Uncharacterized protein C20orf96	C20orf96	Homo sapiens (Human)	363							
Q9NUJ7	reviewed	PLCX1_HUMAN	PI-PLC X domain-containing protein 1	PLCXD1	Homo sapiens (Human)	323		MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.	lipid metabolic process [GO:0006629]	cytoplasm [GO:0005737]	phosphoric diester hydrolase activity [GO:0008081]	cytoplasm [GO:0005737]; phosphoric diester hydrolase activity [GO:0008081]; lipid metabolic process [GO:0006629]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22732399}.
Q9NUR3	reviewed	TM74B_HUMAN	Transmembrane protein 74B	TMEM74B C20orf46	Homo sapiens (Human)	256				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q9NVM6	reviewed	DJC17_HUMAN	DnaJ homolog subfamily C member 17	DNAJC17	Homo sapiens (Human)	304	FUNCTION: May negatively affect PAX8-induced thyroglobulin/TG transcription. {ECO:0000250|UniProtKB:Q91WT4}.		negative regulation of transcription by RNA polymerase II [GO:0000122]; spliceosomal complex disassembly [GO:0000390]	cytoplasm [GO:0005737]; spliceosomal complex [GO:0005681]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; negative regulation of transcription by RNA polymerase II [GO:0000122]; spliceosomal complex disassembly [GO:0000390]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:D3ZSC8}. Nucleus {ECO:0000250|UniProtKB:D3ZSC8}. Note=Predominantly nuclear. {ECO:0000250|UniProtKB:D3ZSC8}.
Q9NVV2	reviewed	CS073_HUMAN	Putative uncharacterized protein C19orf73	C19orf73	Homo sapiens (Human)	129							
Q9NWW7	reviewed	CB042_HUMAN	Uncharacterized protein C2orf42	C2orf42	Homo sapiens (Human)	574				nucleoplasm [GO:0005654]; nucleus [GO:0005634]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]	
Q9NX00	reviewed	TM160_HUMAN	Transmembrane protein 160	TMEM160	Homo sapiens (Human)	188				mitochondrial inner membrane [GO:0005743]		mitochondrial inner membrane [GO:0005743]	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:34936870}; Multi-pass membrane protein {ECO:0000255}.
Q9NX31	reviewed	OSER1_HUMAN	Oxidative stress-responsive serine-rich protein 1 (Oxidative stress-responsive protein 1) (Peroxide-inducible transcript 1 protein)	OSER1 C20orf111 BM-038 HSPC168 HSPC207	Homo sapiens (Human)	292			cellular response to hydrogen peroxide [GO:0070301]			cellular response to hydrogen peroxide [GO:0070301]	
Q9NX36	reviewed	DJC28_HUMAN	DnaJ homolog subfamily C member 28	DNAJC28 C21orf55 C21orf78	Homo sapiens (Human)	388	FUNCTION: May have a role in protein folding or as a chaperone.						
Q9NXS3	reviewed	KLH28_HUMAN	Kelch-like protein 28 (BTB/POZ domain-containing protein 5)	KLHL28 BTBD5	Homo sapiens (Human)	571							
Q9NYP8	reviewed	CU062_HUMAN	Uncharacterized protein C21orf62 (B37)	C21orf62 C21orf120	Homo sapiens (Human)	219							
Q9NZY2	reviewed	FA30A_HUMAN	Putative uncharacterized protein FAM30A	FAM30A C14orf110 KIAA0125 HSPC053	Homo sapiens (Human)	134							
Q9P1F3	reviewed	ABRAL_HUMAN	Costars family protein ABRACL (ABRA C-terminal-like protein)	ABRACL C6orf115 HSPC280 PRO2013	Homo sapiens (Human)	81			regulation of actin filament-based process [GO:0032970]			regulation of actin filament-based process [GO:0032970]	
Q9P1G2	reviewed	RBAS1_HUMAN	Putative uncharacterized protein encoded by RBM12B-AS1 (RBM12B antisense RNA 1) (RBM12B antisense gene protein 1)	RBM12B-AS1 C8orf39 PRO1905	Homo sapiens (Human)	102							
Q9P1V8	reviewed	SAM15_HUMAN	Sterile alpha motif domain-containing protein 15 (SAM domain-containing protein 15)	SAMD15 C14orf174 FAM15A	Homo sapiens (Human)	674							
Q9P217	reviewed	ZSWM5_HUMAN	Zinc finger SWIM domain-containing protein 5	ZSWIM5 KIAA1511	Homo sapiens (Human)	1185				Cul2-RING ubiquitin ligase complex [GO:0031462]; extracellular space [GO:0005615]	zinc ion binding [GO:0008270]	Cul2-RING ubiquitin ligase complex [GO:0031462]; extracellular space [GO:0005615]; zinc ion binding [GO:0008270]	
Q9P298	reviewed	HIG1B_HUMAN	HIG1 domain family member 1B (Protein CLST 11240)	HIGD1B	Homo sapiens (Human)	99			mitochondrial respirasome assembly [GO:0097250]	membrane [GO:0016020]; mitochondrion [GO:0005739]		membrane [GO:0016020]; mitochondrion [GO:0005739]; mitochondrial respirasome assembly [GO:0097250]	SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00836}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00836}.
Q9P2W6	reviewed	CK021_HUMAN	Uncharacterized protein C11orf21	C11orf21	Homo sapiens (Human)	132				cytoplasm [GO:0005737]		cytoplasm [GO:0005737]	SUBCELLULAR LOCATION: Cytoplasm.
Q9P2X7	reviewed	DEC1_HUMAN	Deleted in esophageal cancer 1 (Candidate tumor suppressor CTS9)	DELEC1 CTS9 DEC1	Homo sapiens (Human)	70	FUNCTION: Candidate tumor suppressor. {ECO:0000269|PubMed:10612805}.		negative regulation of cell population proliferation [GO:0008285]			negative regulation of cell population proliferation [GO:0008285]	
Q9P2X8	reviewed	CI027_HUMAN	Putative uncharacterized protein encoded by LINC00474 (Protein EST-YD1)	LINC00474 C9orf27	Homo sapiens (Human)	69							
Q9UBP8	reviewed	KAAG1_HUMAN	Kidney-associated antigen 1 (RU2 antisense gene protein)	KAAG1 RU2AS	Homo sapiens (Human)	84			immune response [GO:0006955]			immune response [GO:0006955]	
Q9UEU5	reviewed	GGE2D_HUMAN	G antigen 2D (GAGE-2D) (Cancer/testis antigen 4.8) (CT4.8) (G antigen 8) (GAGE-8)	GAGE2D; GAGE8	Homo sapiens (Human)	116		MISCELLANEOUS: This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.					
Q9UFV1	reviewed	TBC29_HUMAN	Putative TBC1 domain family member 29	TBC1D29P TBC1D29	Homo sapiens (Human)	150							
Q9UH64	reviewed	NSGX_HUMAN	Putative protein CDKN2A-DT (CDKN2A antisense RNA 1) (CDKN2A antisense gene protein 1) (Protein CDKN2A-AS1) (Susceptibility protein NSG-x)	CDKN2A-DT C9orf53 CDKN2A-AS1	Homo sapiens (Human)	79							
Q9UHA2	reviewed	S18L2_HUMAN	SS18-like protein 2 (SYT homolog 2)	SS18L2	Homo sapiens (Human)	77					transcription coactivator activity [GO:0003713]	transcription coactivator activity [GO:0003713]	
Q9UHL3	reviewed	F153A_HUMAN	Protein FAM153A (Renal carcinoma antigen NY-REN-7)	FAM153A KIAA0752	Homo sapiens (Human)	310							
Q9UHQ7	reviewed	TCAL9_HUMAN	Transcription elongation factor A protein-like 9 (TCEA-like protein 9) (Transcription elongation factor S-II protein-like 9) (WW domain-binding protein 5) (WBP-5)	TCEAL9 WBP5	Homo sapiens (Human)	104	FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.			nucleus [GO:0005634]		nucleus [GO:0005634]	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
Q9UIY3	reviewed	RWD2A_HUMAN	RWD domain-containing protein 2A	RWDD2A RWDD2	Homo sapiens (Human)	292							
Q9UJQ7	reviewed	SCP2D_HUMAN	SCP2 sterol-binding domain-containing protein 1	SCP2D1 C20orf79	Homo sapiens (Human)	156				cytosol [GO:0005829]		cytosol [GO:0005829]	
Q9UK00	reviewed	CC018_HUMAN	Uncharacterized protein C3orf18 (Protein G20)	C3orf18	Homo sapiens (Human)	162				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9ULE4	reviewed	F184B_HUMAN	Protein FAM184B	FAM184B KIAA1276	Homo sapiens (Human)	1060							
Q9ULG3	reviewed	CFA92_HUMAN	Uncharacterized protein CFAP92 (Putative cilia and flagella associated protein 92)	CFAP92 KIAA1257	Homo sapiens (Human)	409							
Q9ULI1	reviewed	NWD2_HUMAN	NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239)	NWD2 KIAA1239	Homo sapiens (Human)	1742							
Q9ULN7	reviewed	PNM8B_HUMAN	Paraneoplastic antigen-like protein 8B (PNMA-like protein 2)	PNMA8B KIAA1183 PNMAL2	Homo sapiens (Human)	635							
Q9UNZ5	reviewed	L10K_HUMAN	Leydig cell tumor 10 kDa protein homolog	C19orf53 HSPC023	Homo sapiens (Human)	99	FUNCTION: May have a potential role in hypercalcemia of malignancy. {ECO:0000250}.						
Q9Y442	reviewed	CV024_HUMAN	Putative uncharacterized protein YWHAH-AS1 (YWHAH antisense RNA 1)	YWHAH-AS1 C22orf24	Homo sapiens (Human)	160				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9Y4M8	reviewed	CH071_HUMAN	Putative uncharacterized protein encoded by LINC00588	LINC00588 C8orf71	Homo sapiens (Human)	146							
Q9Y546	reviewed	LRC42_HUMAN	Leucine-rich repeat-containing protein 42	LRRC42	Homo sapiens (Human)	428							
Q9Y5L5	reviewed	LENEP_HUMAN	Lens epithelial cell protein LEP503	LENEP LEP503	Homo sapiens (Human)	61	FUNCTION: May play a role in lens epithelial cell differentiation.		lens development in camera-type eye [GO:0002088]		DNA binding [GO:0003677]	DNA binding [GO:0003677]; lens development in camera-type eye [GO:0002088]	
Q9Y5M1	reviewed	F215A_HUMAN	Uncharacterized protein FAM215A (Apoptosis-related protein 2) (APR-2)	FAM215A APR2 C17orf88	Homo sapiens (Human)	114							
Q9Y5V0	reviewed	ZN706_HUMAN	Zinc finger protein 706	ZNF706 HSPC038 PNAS-113	Homo sapiens (Human)	76	FUNCTION: Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4. {ECO:0000250|UniProtKB:Q9D115}.		negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; regulation of translation [GO:0006417]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; regulation of translation [GO:0006417]	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D115}. Nucleus {ECO:0000250|UniProtKB:Q9D115}.
Q9Y675	reviewed	SNURF_HUMAN	SNRPN upstream reading frame protein	SNURF	Homo sapiens (Human)	71		MISCELLANEOUS: Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF. In addition to the primary 1.6-kb bicistronic SNURF-SNRPN transcript, SNURF-only transcript is also detected.		nuclear speck [GO:0016607]; nucleus [GO:0005634]	ATPase binding [GO:0051117]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; ATPase binding [GO:0051117]	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10318933}.
Q9Y6J3	reviewed	SMA5O_HUMAN	SMAD5 antisense gene protein 1 (10.3 kDa proline-rich protein DAMS) (SMAD5 antisense RNA 1) (SMAD5 opposite strand protein)	SMAD5-AS1 DAMS SMAD5OS	Homo sapiens (Human)	95		MISCELLANEOUS: This protein is coded from a SMAD5 gene antisense transcript.	signal transduction [GO:0007165]			signal transduction [GO:0007165]	
Q9Y6Z5	reviewed	AFDDT_HUMAN	Putative uncharacterized protein AFDN-DT (AFDN divergent transcript) (Protein HGC6.4)	AFDN-DT AFDN-AS1 C6orf124	Homo sapiens (Human)	254							
S4R3P1	reviewed	HMN13_HUMAN	Humanin-like 13 (HN13) (MT-RNR2-like protein 13)	MTRNR2L13	Homo sapiens (Human)	24	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.		negative regulation of execution phase of apoptosis [GO:1900118]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	receptor antagonist activity [GO:0048019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; negative regulation of execution phase of apoptosis [GO:1900118]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
S4R3Y5	reviewed	HMN11_HUMAN	Humanin-like 11 (HN11) (MT-RNR2-like protein 11)	MTRNR2L11	Homo sapiens (Human)	24	FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.		negative regulation of execution phase of apoptosis [GO:1900118]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	receptor antagonist activity [GO:0048019]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; negative regulation of execution phase of apoptosis [GO:1900118]	SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
X6R8D5	reviewed	CMIP3_HUMAN	Putative uncharacterized protein CIMIP3 (Ciliary microtubule inner protein 3) (GUCA1A neighbor)	CIMIP3 GUCA1ANB	Homo sapiens (Human)	127							
A0A024R1R8	reviewed	TMA7B_HUMAN	Translation machinery-associated protein 7B	TMA7B	Homo sapiens (Human)	64							
A0A087WV53	reviewed	SPEGN_HUMAN	SPEG neighbor protein	SPEGNB	Homo sapiens (Human)	238							
A0A096LP01	reviewed	SIM26_HUMAN	Small integral membrane protein 26	SMIM26	Homo sapiens (Human)	95				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A096LPI5	reviewed	GVQW2_HUMAN	Putative uncharacterized protein CCDC28A-AS1 (GVQW motif-containing protein 2)	CCDC28A-AS1 GVQW2	Homo sapiens (Human)	108							
A0A0B4J1W7	reviewed	NPIA9_HUMAN	Nuclear pore complex-interacting protein family member A9	NPIPA9	Homo sapiens (Human)	369							
A0A0J9YX94	reviewed	PMA6F_HUMAN	Paraneoplastic antigen Ma6F	PNMA6F PNMA6BL	Homo sapiens (Human)	578							
A0A0J9YXQ4	reviewed	PMA6E_HUMAN	Paraneoplastic antigen Ma6E	PNMA6E	Homo sapiens (Human)	647							
A0A0J9YXV3	reviewed	GREP1_HUMAN	Glycine-rich extracellular protein 1 (Long intergenic non-protein coding RNA 514)	GREP1 LINC00514	Homo sapiens (Human)	536							
A0A0U1RQG5	reviewed	CT47C_HUMAN	Cancer/testis antigen family 47 member C1	CT47C1	Homo sapiens (Human)	324							
A0A0U1RQS6	reviewed	TM275_HUMAN	Transmembrane protein 275	TMEM275	Homo sapiens (Human)	177				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A0A0U1RR37	reviewed	CA232_HUMAN	Uncharacterized protein C1orf232	C1orf232	Homo sapiens (Human)	186							
A0A0U1RRK4	reviewed	LBHD2_HUMAN	LBH domain-containing protein 2	LBHD2	Homo sapiens (Human)	108							
A0A1B0GTC6	reviewed	CC085_HUMAN	Uncharacterized protein C3orf85	C3orf85	Homo sapiens (Human)	90							
A0A1B0GTI1	reviewed	CC201_HUMAN	Coiled-coil domain-containing protein 201	CCDC201	Homo sapiens (Human)	187							
A0A1B0GTJ6	reviewed	SAXO3_HUMAN	Stabilizer of axonemal microtubules 3	SAXO3	Homo sapiens (Human)	334							
A0A1B0GTK5	reviewed	F236D_HUMAN	Protein FAM236D	FAM236D	Homo sapiens (Human)	79							
A0A1B0GTR3	reviewed	CX05A_HUMAN	Uncharacterized protein CXorf51A	CXorf51A CXorf51	Homo sapiens (Human)	108							
A0A1B0GTR4	reviewed	SPRR5_HUMAN	Putative small proline-rich protein 5	SPRR5	Homo sapiens (Human)	108							
A0A1B0GTU2	reviewed	CTXD1_HUMAN	Cortexin domain-containing 1 protein	CTXND1	Homo sapiens (Human)	59				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GU29	reviewed	SIM28_HUMAN	Small integral membrane protein 28	SMIM28	Homo sapiens (Human)	152				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GU33	reviewed	TEX53_HUMAN	Testis-expressed protein 53	TEX53	Homo sapiens (Human)	70							
A0A1B0GU71	reviewed	C97D2_HUMAN	Uncharacterized protein CFAP97D2 (CFAP97 domain-containing protein 2)	CFAP97D2	Homo sapiens (Human)	98							
A0A1B0GUA5	reviewed	SIM32_HUMAN	Small integral membrane protein 32	SMIM32	Homo sapiens (Human)	103				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GUA6	reviewed	CC195_HUMAN	Putative coiled-coil domain-containing protein 195	CCDC195	Homo sapiens (Human)	201							
A0A1B0GUA9	reviewed	CM046_HUMAN	Uncharacterized protein C13orf46	C13orf46	Homo sapiens (Human)	212							
A0A1B0GUC4	reviewed	MYCOS_HUMAN	Myocilin opposite strand protein	MYOCOS	Homo sapiens (Human)	108							
A0A1B0GUJ8	reviewed	PNM8C_HUMAN	Paraneoplastic antigen-like protein 8C	PNMA8C	Homo sapiens (Human)	204							
A0A1B0GUQ0	reviewed	F236A_HUMAN	Protein FAM236A	FAM236A	Homo sapiens (Human)	79							
A0A1B0GUS0	reviewed	CS085_HUMAN	Uncharacterized protein C19orf85	C19orf85	Homo sapiens (Human)	222							
A0A1B0GUT2	reviewed	CJ143_HUMAN	Uncharacterized protein C10orf143	C10orf143	Homo sapiens (Human)	108							
A0A1B0GUU1	reviewed	CQ113_HUMAN	Uncharacterized protein C17orf113	C17orf113	Homo sapiens (Human)	675							
A0A1B0GUV1	reviewed	CQ114_HUMAN	Uncharacterized protein C17orf114	C17orf114	Homo sapiens (Human)	79							
A0A1B0GV22	reviewed	F236B_HUMAN	Protein FAM236B	FAM236B	Homo sapiens (Human)	79							
A0A1B0GV90	reviewed	CTXD2_HUMAN	Cortexin domain containing 2	CTXND2	Homo sapiens (Human)	55				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GV96	reviewed	CHD9N_HUMAN	CHD9 neighbor protein	CHD9NB	Homo sapiens (Human)	52							
A0A1B0GVG4	reviewed	CC194_HUMAN	Coiled-coil domain-containing protein 194	CCDC194	Homo sapiens (Human)	234							
A0A1B0GVG6	reviewed	TEX54_HUMAN	Testis-expressed protein 54	TEX54	Homo sapiens (Human)	124							
A0A1B0GVH6	reviewed	CM042_HUMAN	Uncharacterized protein C13orf42	C13orf42	Homo sapiens (Human)	325							
A0A1B0GVH7	reviewed	IQCM_HUMAN	IQ domain-containing protein M	IQCM	Homo sapiens (Human)	501							
A0A1B0GVM5	reviewed	ETDC_HUMAN	Embryonic testis differentiation protein homolog C	ETDC	Homo sapiens (Human)	59							
A0A1B0GVQ3	reviewed	CC200_HUMAN	Coiled-coil domain-containing protein 200	CCDC200	Homo sapiens (Human)	168							
A0A1B0GVR7	reviewed	F240C_HUMAN	Protein FAM240C	FAM240C	Homo sapiens (Human)	95							
A0A1B0GVT2	reviewed	SIM36_HUMAN	Small integral membrane protein 36	SMIM36	Homo sapiens (Human)	93				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1B0GVZ2	reviewed	F240B_HUMAN	Protein FAM240B	FAM240B	Homo sapiens (Human)	78							
A0A1B0GVZ9	reviewed	TM269_HUMAN	Transmembrane protein 269	TMEM269	Homo sapiens (Human)	203				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
A0A1B0GW35	reviewed	EXC1L_HUMAN	Exocyst complex component 1-like	EXOC1L	Homo sapiens (Human)	172							
A0A1B0GW54	reviewed	SIM39_HUMAN	Small integral membrane protein 39	SMIM39	Homo sapiens (Human)	56				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A1W2PP97	reviewed	THSD8_HUMAN	Thrombospondin type-1 domain-containing protein 8	THSD8	Homo sapiens (Human)	115							
A0A1W2PPE3	reviewed	CA202_HUMAN	Uncharacterized protein C1orf202	C1orf202	Homo sapiens (Human)	182							
A0A1W2PQ72	reviewed	MSD7_HUMAN	Myb/SANT-like DNA-binding domain-containing protein 7	MSANTD7	Homo sapiens (Human)	361							
A0A286YFK9	reviewed	SIM38_HUMAN	Small integral membrane protein 38	SMIM38	Homo sapiens (Human)	51				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A2R8Y2Y2	reviewed	CHO90_HUMAN	Uncharacterized protein C8orf90	C8orf90	Homo sapiens (Human)	192							
A0A2R8YCJ5	reviewed	SIM41_HUMAN	Small integral membrane protein 41	SMIM41	Homo sapiens (Human)	93				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A3B3IT52	reviewed	MSD5_HUMAN	Putative uncharacterized protein MSANTD5 (Myb/SANT DNA binding domain-containing protein 5)	MSANTD5	Homo sapiens (Human)	213							
A0A411D538	reviewed	SCPPQ_HUMAN	Secretory calcium-binding phosphoprotein proline-glutamine rich 1	SCPPPQ1	Homo sapiens (Human)	79	FUNCTION: Tooth-associated epithelia protein that may participate in structuring the basal lamina at cell-tooth interface. {ECO:0000250|UniProtKB:D6QY17}.						SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:D6QY17}.
A0A494C0N9	reviewed	F246B_HUMAN	Protein FAM246B	FAM246B	Homo sapiens (Human)	232							
A0A494C0Y3	reviewed	F246A_HUMAN	Protein FAM246A	FAM246A	Homo sapiens (Human)	232							
A0A5F9ZH02	reviewed	SIM42_HUMAN	Small integral membrane protein 42	SMIM42	Homo sapiens (Human)	70				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
A0A8I5KY20	reviewed	CC92B_HUMAN	Coiled-coil domain-containing 92B	CCDC92B	Homo sapiens (Human)	255							
A0A8V8TMC4	reviewed	CYL1B_HUMAN	Cyclin-Y-like protein 1B	CCNYL1B	Homo sapiens (Human)	285							
A1L4L8	reviewed	PL8L1_HUMAN	PLAC8-like protein 1	PLAC8L1	Homo sapiens (Human)	177							
A1L4Q6	reviewed	YK033_HUMAN	Putative uncharacterized protein FLJ41423		Homo sapiens (Human)	167							
A2JGV3	reviewed	TARP_HUMAN	T-cell receptor gamma alternate reading frame protein (TARP)	TRGC1	Homo sapiens (Human)	58		MISCELLANEOUS: Encoded in an alternative reading frame of the T-cell receptor gamma chain gene which is composed of variable (Vgamma), joining (Jgamma), and constant (Cgamma) gene segments. Originates within an intron directly upstream of the Jgamma1.2 gene segment and contains three exons from the Cgamma1 segment. {ECO:0000269|PubMed:10430935, ECO:0000269|PubMed:10931945}.; MISCELLANEOUS: Expressed in prostate cancer and breast cancer cells with little or no expression detected in normal breast tissue (PubMed:10931945). In prostate cancer cells, increases cell growth rate and changes expression levels of a number of genes including up-regulation of CAV1, CAV2, AREG and CXCL1/GRO1 and down-regulation of IL1B (PubMed:11719440). Localizes to the mitochondrion outer membrane in prostate cancer cells (PubMed:15150260). In acute myeloid leukemia cells, shows perinuclear staining and some localization at the endoplasmic reticulum (PubMed:31371409). Expressed at significantly higher levels in primary salivary adenoid cystic carcinomas (SACC) compared with adjacent non-cancerous tissues and promotes the proliferation, migration and invasion of SACC cells (PubMed:28153567). Expressed at higher levels in endometrial carcinomas than in normal endometrial tissue (PubMed:24238509). {ECO:0000269|PubMed:10931945, ECO:0000269|PubMed:11719440, ECO:0000269|PubMed:15150260, ECO:0000269|PubMed:24238509, ECO:0000269|PubMed:28153567, ECO:0000269|PubMed:31371409}.					
A4D0Y5	reviewed	CG077_HUMAN	Uncharacterized protein encoded by LINC03043 (Long intergenic non-protein coding RNA 3043)	LINC03043 C7orf77	Homo sapiens (Human)	90							
A4D1N5	reviewed	YG018_HUMAN	Putative uncharacterized protein FLJ40288		Homo sapiens (Human)	150							
A4D250	reviewed	BLACE_HUMAN	B-cell acute lymphoblastic leukemia-expressed protein	BLACE	Homo sapiens (Human)	179							
A4QN01	reviewed	CJ040_HUMAN	Putative uncharacterized protein encoded by LINC01553	LINC01553 C10orf40	Homo sapiens (Human)	128							
A6NC62	reviewed	RAKDN_HUMAN	Putative RBAK downstream neighbor protein	RBAKDN	Homo sapiens (Human)	111							
A6NCN8	reviewed	TEX52_HUMAN	Testis-expressed protein 52	TEX52	Homo sapiens (Human)	305							
A6NCS6	reviewed	CB072_HUMAN	Uncharacterized protein C2orf72	C2orf72	Homo sapiens (Human)	295							
A6NDN8	reviewed	UBIML_HUMAN	Putative ubiquitin-like protein FUBI-like protein ENSP00000310146		Homo sapiens (Human)	102							
A6NF36	reviewed	CC182_HUMAN	Coiled-coil domain-containing protein 182	CCDC182	Homo sapiens (Human)	153			female gonad development [GO:0008585]			female gonad development [GO:0008585]	
A6NFE3	reviewed	EFC10_HUMAN	EF-hand calcium-binding domain-containing protein 10	EFCAB10	Homo sapiens (Human)	127					calcium ion binding [GO:0005509]	calcium ion binding [GO:0005509]	
A6NGY3	reviewed	CE052_HUMAN	Uncharacterized protein C5orf52	C5orf52	Homo sapiens (Human)	159							
A6NHR8	reviewed	FA47D_HUMAN	Putative protein FAM47D	FAM47DP	Homo sapiens (Human)	397							
A6NHS1	reviewed	YK042_HUMAN	Putative uncharacterized protein ENSP00000347057		Homo sapiens (Human)	94							
A6NIU2	reviewed	CU037_HUMAN	Putative uncharacterized protein encoded by LINC01549	LINC01549 C21orf37	Homo sapiens (Human)	74							
A6NJI1	reviewed	CK086_HUMAN	Uncharacterized protein C11orf86	C11orf86	Homo sapiens (Human)	115							
A6NJI9	reviewed	LRC72_HUMAN	Leucine-rich repeat-containing protein 72	LRRC72	Homo sapiens (Human)	287							
A6NJR5	reviewed	SPDL3_HUMAN	Putative speedy protein-like protein 3		Homo sapiens (Human)	290					protein kinase binding [GO:0019901]	protein kinase binding [GO:0019901]	
A6NKX1	reviewed	F223B_HUMAN	Protein FAM223B	FAM223B CXorf52B LINC00204B	Homo sapiens (Human)	122							
A6NL46	reviewed	YF016_HUMAN	Putative UPF0607 protein ENSP00000332738		Homo sapiens (Human)	340							
A6NM66	reviewed	CU054_HUMAN	Uncharacterized protein encoded by LINC01548	LINC01548 C21orf54	Homo sapiens (Human)	108							
A6NML5	reviewed	TM212_HUMAN	Transmembrane protein 212	TMEM212	Homo sapiens (Human)	194				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
A6NN06	reviewed	U633A_HUMAN	Putative UPF0633 protein MGC21881		Homo sapiens (Human)	94							
A6NNH2	reviewed	F90AR_HUMAN	Protein FAM90A27P	FAM90A27P	Homo sapiens (Human)	459							
A6NNX1	reviewed	RIAD1_HUMAN	RIIa domain-containing protein 1	RIIAD1 C1orf230	Homo sapiens (Human)	92							
A8K554	reviewed	ZN815_HUMAN	Putative protein ZNF815	ZNF815P ZNF815	Homo sapiens (Human)	130							
A8MT66	reviewed	YU005_HUMAN	Putative uncharacterized protein ENSP00000383407		Homo sapiens (Human)	165							
A8MTL0	reviewed	IQCF5_HUMAN	IQ domain-containing protein F5	IQCF5	Homo sapiens (Human)	148					calmodulin binding [GO:0005516]	calmodulin binding [GO:0005516]	
A8MTW9	reviewed	YB043_HUMAN	Putative uncharacterized protein ENSP00000380674		Homo sapiens (Human)	85				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A8MTZ7	reviewed	CL071_HUMAN	Uncharacterized protein C12orf71	C12orf71	Homo sapiens (Human)	269							
A8MU10	reviewed	YQ047_HUMAN	Putative uncharacterized protein ENSP00000381562		Homo sapiens (Human)	97							
A8MU93	reviewed	CQ100_HUMAN	Uncharacterized protein C17orf100	C17orf100	Homo sapiens (Human)	118							
A8MUA0	reviewed	YB057_HUMAN	Putative UPF0607 protein ENSP00000381514		Homo sapiens (Human)	341							
A8MUI8	reviewed	YA034_HUMAN	Putative UPF0607 protein ENSP00000383783		Homo sapiens (Human)	341							
A8MUN3	reviewed	YQ048_HUMAN	Putative uncharacterized protein ENSP00000381830		Homo sapiens (Human)	132				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
A8MUU9	reviewed	YV023_HUMAN	Putative uncharacterized protein ENSP00000383309		Homo sapiens (Human)	505							
A8MV24	reviewed	SPMA1_HUMAN	Sperm microtubule associated protein 1	SPMAP1 C17orf98	Homo sapiens (Human)	154							
A8MV72	reviewed	YH009_HUMAN	Putative UPF0607 protein ENSP00000382826		Homo sapiens (Human)	311							
A8MVM7	reviewed	YD021_HUMAN	Putative uncharacterized protein ENSP00000382790		Homo sapiens (Human)	634							
A8MWE9	reviewed	EFCB8_HUMAN	EF-hand calcium-binding domain-containing protein 8	EFCAB8	Homo sapiens (Human)	144					calcium ion binding [GO:0005509]	calcium ion binding [GO:0005509]	
A8MWP4	reviewed	YU008_HUMAN	Putative uncharacterized protein ENSP00000401716		Homo sapiens (Human)	228							
A8MX80	reviewed	YM017_HUMAN	Putative UPF0607 protein ENSP00000383144		Homo sapiens (Human)	341							
A8MY62	reviewed	BLML_HUMAN	Putative beta-lactamase-like 1	LACTBL1	Homo sapiens (Human)	500							
A8MYJ7	reviewed	TTC34_HUMAN	Tetratricopeptide repeat protein 34 (TPR repeat protein 34)	TTC34	Homo sapiens (Human)	566							
A8MYZ5	reviewed	IQCF6_HUMAN	IQ domain-containing protein F6	IQCF6	Homo sapiens (Human)	107					calmodulin binding [GO:0005516]	calmodulin binding [GO:0005516]	
A8MZ25	reviewed	YQ037_HUMAN	Putative uncharacterized protein FLJ38767		Homo sapiens (Human)	164							
A8MZF0	reviewed	PRR33_HUMAN	Proline-rich protein 33	PRR33 C11orf89	Homo sapiens (Human)	331							
A8MZG2	reviewed	CP090_HUMAN	Uncharacterized protein C16orf90	C16orf90	Homo sapiens (Human)	182							
B1AMM8	reviewed	CI107_HUMAN	Putative uncharacterized protein encoded by LINC00587	LINC00587 C9orf107	Homo sapiens (Human)	73							
B3EWG3	reviewed	FM25A_HUMAN	Protein FAM25A	FAM25A	Homo sapiens (Human)	89							
B3EWG6	reviewed	FM25G_HUMAN	Protein FAM25G	FAM25G	Homo sapiens (Human)	89							
B5MCY1	reviewed	TDR15_HUMAN	Tudor domain-containing protein 15	TDRD15	Homo sapiens (Human)	1934							
B9A014	reviewed	F243A_HUMAN	Uncharacterized protein C21orf140 (Protein FAM243A)	C21orf140 FAM243A	Homo sapiens (Human)	251							
C9J302	reviewed	CD051_HUMAN	Uncharacterized protein C4orf51	C4orf51	Homo sapiens (Human)	202							
C9J3I9	reviewed	CE058_HUMAN	Putative uncharacterized protein C5orf58	C5orf58	Homo sapiens (Human)	81							
C9J6K1	reviewed	CS081_HUMAN	Putative uncharacterized protein C19orf81	C19orf81	Homo sapiens (Human)	198							
C9JC47	reviewed	F157A_HUMAN	Putative protein FAM157A	FAM157A	Homo sapiens (Human)	383							
C9JFL3	reviewed	PHGR1_HUMAN	Proline, histidine and glycine-rich protein 1	PHGR1	Homo sapiens (Human)	82							
D0EPY3	reviewed	SIM47_HUMAN	Small integral membrane protein 47	SMIM47	Homo sapiens (Human)	28				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
E9PRG8	reviewed	CK098_HUMAN	Uncharacterized protein C11orf98	C11orf98	Homo sapiens (Human)	123							
F2Z398	reviewed	LMO7D_HUMAN	LMO7 downstream neighbor protein	LMO7DN C13orf45	Homo sapiens (Human)	122							
F2Z3F1	reviewed	CE067_HUMAN	Uncharacterized protein C5orf67	C5orf67	Homo sapiens (Human)	127							
F2Z3M2	reviewed	CQ112_HUMAN	Uncharacterized protein encoded by LINC02876 (Long intergenic non-protein coding RNA 2876)	LINC02876 C17orf112	Homo sapiens (Human)	114							
H3BMG3	reviewed	SMKR1_HUMAN	Small lysine-rich protein 1	SMKR1	Homo sapiens (Human)	65							
H3BNL1	reviewed	CC084_HUMAN	Uncharacterized protein C3orf84	C3orf84	Homo sapiens (Human)	204							
H3BNL8	reviewed	ARMD2_HUMAN	Armadillo-like helical domain-containing protein 2	ARMH2 C6orf229	Homo sapiens (Human)	230							
H3BQW9	reviewed	F229A_HUMAN	Protein FAM229A	FAM229A	Homo sapiens (Human)	127							
I3L1E1	reviewed	CS084_HUMAN	Uncharacterized protein C19orf84	C19orf84	Homo sapiens (Human)	186							
J3KSC0	reviewed	CR064_HUMAN	Putative uncharacterized protein encoded by LINC01387	LINC01387 C18orf64	Homo sapiens (Human)	135							
O15225	reviewed	INE1_HUMAN	Putative inactivation escape 1 protein	INE1 DXS6974E	Homo sapiens (Human)	51							
O15544	reviewed	GR6_HUMAN	Protein GR6	LINC01565 C3orf27 GR6	Homo sapiens (Human)	149							
O60384	reviewed	ZN861_HUMAN	Putative zinc finger protein 861	ZNF861P	Homo sapiens (Human)	105					DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]	
O60756	reviewed	BCE1_HUMAN	Putative protein BCE-1	BCE1	Homo sapiens (Human)	84							
P0C5K6	reviewed	CT18_HUMAN	Putative tumor antigen NA88-A (Cancer/testis antigen 18) (CT18)	VENTXP1	Homo sapiens (Human)	33							
P0C5K7	reviewed	CT62_HUMAN	Cancer/testis antigen 62 (CT62)	CT62	Homo sapiens (Human)	136							
P0C7U9	reviewed	FA87A_HUMAN	Protein FAM87A	FAM87A	Homo sapiens (Human)	286				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
P0C875	reviewed	F228B_HUMAN	Protein FAM228B	FAM228B	Homo sapiens (Human)	324							
P0C879	reviewed	YJ018_HUMAN	Putative uncharacterized protein FLJ43185		Homo sapiens (Human)	139							
P0C880	reviewed	YT014_HUMAN	Putative uncharacterized protein FLJ40606		Homo sapiens (Human)	135							
P0CE67	reviewed	CC079_HUMAN	Putative uncharacterized protein encoded by LINC02877	LINC02877 C3orf79	Homo sapiens (Human)	100							
P0CF97	reviewed	F200B_HUMAN	Protein FAM200B	FAM200B C4orf53	Homo sapiens (Human)	657							
P0CG42	reviewed	F157B_HUMAN	Putative protein FAM157B	FAM157B	Homo sapiens (Human)	384							
P0CG43	reviewed	F157C_HUMAN	Putative protein FAM157C	FAM157C	Homo sapiens (Human)	387							
P0CH98	reviewed	F106C_HUMAN	Protein FAM106C (FAM106C pseudogene)	FAM106C FAM106CP	Homo sapiens (Human)	169							
P0CZ25	reviewed	D10OS_HUMAN	Uncharacterized protein DNAH10OS	DNAH10OS	Homo sapiens (Human)	163		MISCELLANEOUS: This protein has no orthologs in other species and appears to be the product of a protein-coding gene which has arisen since divergence from chimp.					
P0DH78	reviewed	RN224_HUMAN	RING finger protein 224	RNF224	Homo sapiens (Human)	156					metal ion binding [GO:0046872]	metal ion binding [GO:0046872]	
P0DKL9	reviewed	A14EL_HUMAN	ARL14 effector protein-like	ARL14EPL	Homo sapiens (Human)	152							
P0DM63	reviewed	NPIA8_HUMAN	Nuclear pore complex-interacting protein family member A8	NPIPA8	Homo sapiens (Human)	369							
P0DMQ9	reviewed	CH089_HUMAN	Putative uncharacterized protein C8orf89	C8orf89	Homo sapiens (Human)	161							
P0DMU3	reviewed	F231L_HUMAN	FAM231A/C-like protein LOC102723383		Homo sapiens (Human)	169							
P0DMV1	reviewed	CT458_HUMAN	Cancer/testis antigen family 45 member A8 (Cancer/testis antigen 45A8)	CT45A8	Homo sapiens (Human)	189							
P0DMV2	reviewed	CT459_HUMAN	Cancer/testis antigen family 45 member A9 (Cancer/testis antigen 45A9)	CT45A9	Homo sapiens (Human)	189							
P0DMW3	reviewed	SIML1_HUMAN	Small integral membrane protein 10-like protein 1	SMIM10L1	Homo sapiens (Human)	68							
P0DMW4	reviewed	SIL2A_HUMAN	Small integral membrane protein 10-like protein 2A	SMIM10L2A LINC00086 NCRNA00086	Homo sapiens (Human)	78							
P0DMW5	reviewed	SIL2B_HUMAN	Small integral membrane protein 10-like protein 2B	SMIM10L2B LINC00087 NCRNA00087	Homo sapiens (Human)	78							
P0DO97	reviewed	CC192_HUMAN	Coiled-coil domain-containing protein 192	CCDC192 LINC01183	Homo sapiens (Human)	292							
P0DP71	reviewed	F236C_HUMAN	Protein FAM236C	FAM236C	Homo sapiens (Human)	79							
P0DPF5	reviewed	CB27A_HUMAN	Uncharacterized protein C2orf27A	C2orf27A	Homo sapiens (Human)	203							
P0DPF6	reviewed	CB27B_HUMAN	Putative uncharacterized protein CDRT15P3	CDRT15P3 C2orf27B	Homo sapiens (Human)	209							
P0DPP9	reviewed	ETDB_HUMAN	Embryonic testis differentiation protein homolog B	ETDB	Homo sapiens (Human)	59							
P0DPQ3	reviewed	PR20G_HUMAN	Proline-rich protein 20G	PRR20G	Homo sapiens (Human)	210							
P0DQW1	reviewed	SIM46_HUMAN	Small integral membrane protein 46	SMIM46	Homo sapiens (Human)	50				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
P0DV60	reviewed	LCE7A_HUMAN	Late cornified envelope protein 7A	LCE7A	Homo sapiens (Human)	95	FUNCTION: Precursors of the cornified envelope of the stratum corneum. {ECO:0000250|UniProtKB:Q5TA76}.		keratinization [GO:0031424]			keratinization [GO:0031424]	
P13985	reviewed	HRES1_HUMAN	Putative HTLV-1-related endogenous sequence (p25)	HRES1	Homo sapiens (Human)	223							
P58513	reviewed	CU042_HUMAN	Putative uncharacterized protein encoded by LINC00158	LINC00158 C21orf42 NCRNA00158	Homo sapiens (Human)	81							
P59020	reviewed	DSCR9_HUMAN	Down syndrome critical region protein 9	DSCR9	Homo sapiens (Human)	149							
P59022	reviewed	DSC10_HUMAN	Down syndrome critical region protein 10	DSCR10	Homo sapiens (Human)	87							
P86481	reviewed	PR20B_HUMAN	Proline-rich protein 20B	PRR20B	Homo sapiens (Human)	221							
Q05BU3	reviewed	F86JP_HUMAN	Putative protein FAM86JP	FAM86JP	Homo sapiens (Human)	40							
Q0P140	reviewed	YA037_HUMAN	Putative uncharacterized protein HSD52	HSD52	Homo sapiens (Human)	79							
Q0VDD5	reviewed	CQ091_HUMAN	Putative uncharacterized protein encoded by MIR22HG	MIR22HG C17orf91	Homo sapiens (Human)	57							
Q0VFX4	reviewed	YL016_HUMAN	Putative uncharacterized protein LOC100128554		Homo sapiens (Human)	171							
Q13166	reviewed	CATR1_HUMAN	CATR tumorigenic conversion 1 protein (CATR1.3)	CATR1	Homo sapiens (Human)	79							
Q14602	reviewed	ID2B_HUMAN	Putative DNA-binding protein inhibitor ID-2B (Inhibitor of DNA binding 2B)	ID2B	Homo sapiens (Human)	36							
Q14695	reviewed	K0087_HUMAN	Uncharacterized protein KIAA0087	KIAA0087 HA1002	Homo sapiens (Human)	138							
Q17RA5	reviewed	CMAS1_HUMAN	Putative uncharacterized protein C21orf62-AS1 (C21orf62 antisense RNA 1) (C21orf62 antisense gene protein 1)	C21orf62-AS1 C21orf49	Homo sapiens (Human)	79							
Q1RN00	reviewed	YC018_HUMAN	Putative uncharacterized protein LOC151760		Homo sapiens (Human)	199							
Q2M2D7	reviewed	TBC28_HUMAN	TBC1 domain family member 28	TBC1D28	Homo sapiens (Human)	210							
Q3B7I2	reviewed	CNPY1_HUMAN	Protein canopy homolog 1	CNPY1	Homo sapiens (Human)	92							
Q3ZM63	reviewed	ETDA_HUMAN	Embryonic testis differentiation protein homolog A	ETDA	Homo sapiens (Human)	59							
Q495D7	reviewed	CL036_HUMAN	Putative uncharacterized protein encoded by LINC01559	LINC01559 C12orf36	Homo sapiens (Human)	138							
Q499Y3	reviewed	YJ016_HUMAN	Putative uncharacterized protein C10orf88-like		Homo sapiens (Human)	187							
Q4KMX7	reviewed	F106A_HUMAN	Protein FAM106A	FAM106A	Homo sapiens (Human)	169							
Q4W4Y0	reviewed	CN028_HUMAN	Uncharacterized protein C14orf28 (Dopamine receptor-interacting protein 1)	C14orf28 DRIP1	Homo sapiens (Human)	310							
Q52M75	reviewed	CE027_HUMAN	Putative uncharacterized protein encoded by LINC01554 (Protein FIS)	LINC01554 C5orf27	Homo sapiens (Human)	96							
Q53H64	reviewed	AK40L_HUMAN	Putative ANKRD40 C-terminal-like protein	ANKRD40CL C17orf73 LINC00483	Homo sapiens (Human)	114							
Q56UQ5	reviewed	TPT1L_HUMAN	TPT1-like protein		Homo sapiens (Human)	140				cytoplasm [GO:0005737]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]	
Q5JQF7	reviewed	CF100_HUMAN	Putative uncharacterized protein encoded by LINC01556	LINC01556 C6orf100	Homo sapiens (Human)	62							
Q5JWF8	reviewed	ACL10_HUMAN	Actin-like protein 10	ACTL10 C20orf134	Homo sapiens (Human)	245							
Q5PR19	reviewed	YI024_HUMAN	Putative UPF0607 protein LOC392364		Homo sapiens (Human)	223							
Q5STR5	reviewed	SIM40_HUMAN	Small integral membrane protein 40	SMIM40	Homo sapiens (Human)	79				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q5SY85	reviewed	F201A_HUMAN	Protein FAM201A	FAM201A C9orf122	Homo sapiens (Human)	155							
Q5T0J3	reviewed	CA220_HUMAN	Putative uncharacterized protein C1orf220	C1orf220	Homo sapiens (Human)	134							
Q5T1J6	reviewed	F182A_HUMAN	Protein FAM182A	FAM182A C20orf91	Homo sapiens (Human)	154							
Q5T3Y7	reviewed	BVAS1_HUMAN	Putative uncharacterized protein BVES-AS1 (BVES antisense RNA 1) (BVES antisense gene protein 1)	BVES-AS1 C6orf112	Homo sapiens (Human)	98							
Q5T7N8	reviewed	F27D1_HUMAN	Protein FAM27D1	FAM27D1	Homo sapiens (Human)	215							
Q5T7P6	reviewed	TMM78_HUMAN	Transmembrane protein 78	TMEM78	Homo sapiens (Human)	136				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q5T7R7	reviewed	CA185_HUMAN	Uncharacterized protein C1orf185	C1orf185	Homo sapiens (Human)	199				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q5T870	reviewed	PRR9_HUMAN	Proline-rich protein 9	PRR9	Homo sapiens (Human)	116							
Q5TEZ4	reviewed	CF164_HUMAN	Putative uncharacterized protein encoded by LINC01590 (Long intergenic non-protein coding RNA 1590)	LINC01590 C6orf164	Homo sapiens (Human)	76							
Q5TEZ5	reviewed	CF163_HUMAN	Uncharacterized protein C6orf163	C6orf163	Homo sapiens (Human)	329							
Q5VSD8	reviewed	YI029_HUMAN	Putative uncharacterized protein LOC401522		Homo sapiens (Human)	79							
Q5VT33	reviewed	CX031_HUMAN	Putative uncharacterized protein encoded by LINC01545	LINC01545 CXorf31	Homo sapiens (Human)	79							
Q5VT40	reviewed	FA78B_HUMAN	Protein FAM78B	FAM78B	Homo sapiens (Human)	261							
Q5VUE5	reviewed	CA053_HUMAN	Uncharacterized protein C1orf53	C1orf53	Homo sapiens (Human)	145							
Q5VV11	reviewed	U633B_HUMAN	Putative UPF0633 protein ENSP00000303136		Homo sapiens (Human)	94							
Q5VVS0	reviewed	CA140_HUMAN	Putative uncharacterized protein C1orf140	C1orf140	Homo sapiens (Human)	124							
Q68DL7	reviewed	CR063_HUMAN	Uncharacterized protein C18orf63	C18orf63	Homo sapiens (Human)	685							
Q6AWC8	reviewed	YK026_HUMAN	Putative uncharacterized protein LOC100129027		Homo sapiens (Human)	147							
Q6IC83	reviewed	CV042_HUMAN	Uncharacterized protein C22orf42	C22orf42	Homo sapiens (Human)	251							
Q6NUR6	reviewed	R216L_HUMAN	Putative protein RNF216-like	RNF216P1 RNF216L	Homo sapiens (Human)	42							
Q6P435	reviewed	SMG1L_HUMAN	Putative uncharacterized SMG1-like protein		Homo sapiens (Human)	159							
Q6UWF5	reviewed	YF002_HUMAN	Putative uncharacterized protein UNQ5815/PRO19632	UNQ5815/PRO19632	Homo sapiens (Human)	114				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q6UXP9	reviewed	YO001_HUMAN	Putative uncharacterized protein UNQ9370/PRO34162	UNQ9370/PRO34162	Homo sapiens (Human)	181							
Q6UXQ4	reviewed	CB066_HUMAN	Uncharacterized protein C2orf66	C2orf66 UNQ6411/PRO21186	Homo sapiens (Human)	117				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UXR8	reviewed	YS001_HUMAN	Putative uncharacterized protein UNQ6493/PRO21345	UNQ6493/PRO21345	Homo sapiens (Human)	122							
Q6UXV3	reviewed	YV010_HUMAN	Uncharacterized protein UNQ6126/PRO20091	UNQ6126/PRO20091	Homo sapiens (Human)	157				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6UY13	reviewed	YB003_HUMAN	Putative uncharacterized protein UNQ5830/PRO19650/PRO19816	UNQ5830/PRO19650/PRO19816	Homo sapiens (Human)	95				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6W349	reviewed	CD011_HUMAN	Putative uncharacterized protein encoded by LINC00575	LINC00575 C4orf11	Homo sapiens (Human)	94							
Q6XCG6	reviewed	YA011_HUMAN	Putative uncharacterized protein PP632	PP632	Homo sapiens (Human)	107							
Q6ZMV7	reviewed	LEKR1_HUMAN	Protein LEKR1	LEKR1	Homo sapiens (Human)	132							
Q6ZP68	reviewed	ATPUN_HUMAN	Putative protein ATP11AUN (Putative ATP11A upstream neighbor protein)	ATP11AUN C13orf35	Homo sapiens (Human)	121							
Q6ZPA2	reviewed	YS039_HUMAN	Putative uncharacterized protein FLJ26174		Homo sapiens (Human)	131							
Q6ZQT7	reviewed	YJ013_HUMAN	Putative uncharacterized protein FLJ44672		Homo sapiens (Human)	251							
Q6ZQY7	reviewed	YO026_HUMAN	Putative uncharacterized protein FLJ46792		Homo sapiens (Human)	126							
Q6ZR03	reviewed	YU004_HUMAN	Uncharacterized protein FLJ46757		Homo sapiens (Human)	302							
Q6ZR54	reviewed	YN009_HUMAN	Putative uncharacterized protein FLJ46641		Homo sapiens (Human)	194							
Q6ZR85	reviewed	CQ107_HUMAN	Uncharacterized protein C17orf107	C17orf107	Homo sapiens (Human)	190							
Q6ZRG5	reviewed	YQ015_HUMAN	Putative uncharacterized protein FLJ43944		Homo sapiens (Human)	221							
Q6ZRM9	reviewed	YG024_HUMAN	Putative uncharacterized protein FLJ46235		Homo sapiens (Human)	215							
Q6ZRN7	reviewed	YP029_HUMAN	Putative uncharacterized protein FLJ46214		Homo sapiens (Human)	208							
Q6ZRP5	reviewed	YD019_HUMAN	Putative uncharacterized protein FLJ46204		Homo sapiens (Human)	223							
Q6ZRU5	reviewed	YQ032_HUMAN	Putative uncharacterized protein FLJ46089		Homo sapiens (Human)	148				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q6ZRV3	reviewed	CC074_HUMAN	Putative uncharacterized protein encoded by LINC00696	LINC00696 C3orf74	Homo sapiens (Human)	163							
Q6ZRX8	reviewed	YL004_HUMAN	Putative uncharacterized protein FLJ45999		Homo sapiens (Human)	168							
Q6ZS46	reviewed	YF009_HUMAN	Putative uncharacterized protein FLJ45840		Homo sapiens (Human)	218							
Q6ZS49	reviewed	YQ050_HUMAN	Putative uncharacterized protein FLJ45831		Homo sapiens (Human)	121				extracellular space [GO:0005615]		extracellular space [GO:0005615]	
Q6ZS52	reviewed	YF013_HUMAN	Putative uncharacterized protein FLJ45825		Homo sapiens (Human)	159							
Q6ZS92	reviewed	YD022_HUMAN	Putative uncharacterized protein FLJ45721		Homo sapiens (Human)	163							
Q6ZSA8	reviewed	YS025_HUMAN	Putative uncharacterized protein FLJ45684		Homo sapiens (Human)	131							
Q6ZSK4	reviewed	NTAS1_HUMAN	Putative uncharacterized protein NTM-AS1 (NTM antisense RNA 1) (NTM antisense gene protein 1)	NTM-AS1 C11orf39	Homo sapiens (Human)	140							
Q6ZSN1	reviewed	YI023_HUMAN	Putative uncharacterized protein FLJ45355		Homo sapiens (Human)	163							
Q6ZSR3	reviewed	YO027_HUMAN	Putative uncharacterized protein FLJ45275, mitochondrial		Homo sapiens (Human)	168				mitochondrion [GO:0005739]		mitochondrion [GO:0005739]	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
Q6ZSR6	reviewed	YP007_HUMAN	Putative uncharacterized protein FLJ45256		Homo sapiens (Human)	202							
Q6ZSV7	reviewed	YF010_HUMAN	Putative uncharacterized protein FLJ45177		Homo sapiens (Human)	163							
Q6ZTC4	reviewed	YT009_HUMAN	Putative uncharacterized protein FLJ44790		Homo sapiens (Human)	211							
Q6ZTI0	reviewed	YK032_HUMAN	Putative uncharacterized protein FLJ44636		Homo sapiens (Human)	123							
Q6ZTR6	reviewed	ZNFDT_HUMAN	Putative uncharacterized protein ZNF516-DT (ZNF516 divergent transcript)	ZNF516-DT C18orf65	Homo sapiens (Human)	163							
Q6ZTY9	reviewed	CG065_HUMAN	Putative uncharacterized protein LINC02902 (Long intergenic non-protein coding RNA 2902)	LINC02902 C7orf65	Homo sapiens (Human)	151							
Q6ZUG5	reviewed	YC006_HUMAN	Uncharacterized protein FLJ43738		Homo sapiens (Human)	572							
Q6ZUT4	reviewed	YL014_HUMAN	Putative uncharacterized protein FLJ43343		Homo sapiens (Human)	128							
Q6ZV60	reviewed	YL023_HUMAN	Putative uncharacterized protein encoded by LINC00173	LINC00173 NCRNA00173	Homo sapiens (Human)	143							
Q6ZVH6	reviewed	YK004_HUMAN	Putative uncharacterized protein FLJ42569		Homo sapiens (Human)	145							
Q6ZVL8	reviewed	YP033_HUMAN	Putative uncharacterized protein FLJ42384		Homo sapiens (Human)	140							
Q6ZVQ6	reviewed	YS045_HUMAN	Putative uncharacterized protein FLJ42213		Homo sapiens (Human)	151							
Q6ZVU0	reviewed	YK022_HUMAN	Putative uncharacterized protein FLJ42102		Homo sapiens (Human)	165							
Q6ZVW7	reviewed	I17EL_HUMAN	Putative interleukin-17 receptor E-like (IL-17 receptor E-like) (IL-17RE-like)	IL17REL	Homo sapiens (Human)	336					interleukin-17 receptor activity [GO:0030368]	interleukin-17 receptor activity [GO:0030368]	
Q6ZWC4	reviewed	YS043_HUMAN	Putative uncharacterized protein LOC100128429		Homo sapiens (Human)	215							
Q71F78	reviewed	LCA10_HUMAN	Putative lung carcinoma-associated protein 10	LCA10	Homo sapiens (Human)	164							
Q75L30	reviewed	YG027_HUMAN	Putative uncharacterized protein FLJ92257		Homo sapiens (Human)	129							
Q86TA4	reviewed	YB049_HUMAN	Putative uncharacterized protein FLJ44553		Homo sapiens (Human)	180							
Q86TU6	reviewed	CN070_HUMAN	Putative uncharacterized protein encoded by LINC00523	LINC00523 C14orf70	Homo sapiens (Human)	105							
Q86U37	reviewed	CN023_HUMAN	Uncharacterized protein encoded by LINC01551	LINC01551 C14orf23	Homo sapiens (Human)	167							
Q86UQ5	reviewed	GTSC1_HUMAN	Gilles de la Tourette syndrome chromosomal region candidate gene 1 protein	GTSCR1	Homo sapiens (Human)	136				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q8IXQ3	reviewed	CI040_HUMAN	Uncharacterized protein C9orf40	C9orf40	Homo sapiens (Human)	194							
Q8IYB0	reviewed	YK038_HUMAN	Putative uncharacterized protein MGC39545		Homo sapiens (Human)	196							
Q8IZM0	reviewed	CNG1O_HUMAN	Putative CNGA1-overlapping antisense gene protein (Anti-CNG1)		Homo sapiens (Human)	81		MISCELLANEOUS: Located on the opposite DNA strand of the CNGA1 gene at chromosome 4p13. Its transcription may play a role in CNGA1 transcription regulation.					
Q8N1I8	reviewed	CAAS1_HUMAN	Putative uncharacterized protein encoded by CACTIN-AS1 (Cactin antisense RNA 1)	CACTIN-AS1 C19orf29-AS1 C19orf29OS	Homo sapiens (Human)	211							
Q8N1L1	reviewed	CV037_HUMAN	Putative uncharacterized protein encoded by LINC00528	LINC00528 C22orf37	Homo sapiens (Human)	170							
Q8N1V8	reviewed	CJ085_HUMAN	Uncharacterized protein encoded by LINC01561	LINC01561 C10orf85	Homo sapiens (Human)	128							
Q8N1X5	reviewed	YF001_HUMAN	Uncharacterized protein FLJ37310		Homo sapiens (Human)	172							
Q8N2A0	reviewed	CX062_HUMAN	Putative uncharacterized protein encoded by LINC00269	LINC00269 CXorf62 NCRNA00269	Homo sapiens (Human)	174							
Q8N2B8	reviewed	YB035_HUMAN	Putative uncharacterized protein FLJ33534		Homo sapiens (Human)	174							
Q8N2C9	reviewed	UMAS1_HUMAN	Uncharacterized protein UMODL1-AS1 (UMODL1 antisense RNA 1) (UMODL1 antisense gene protein 1)	UMODL1-AS1 C21orf128	Homo sapiens (Human)	162							
Q8N377	reviewed	YJ004_HUMAN	Putative uncharacterized protein LOC387726		Homo sapiens (Human)	158							
Q8N3U1	reviewed	YS014_HUMAN	Putative uncharacterized protein LOC400692		Homo sapiens (Human)	123							
Q8N402	reviewed	YV020_HUMAN	Putative uncharacterized protein LOC388882		Homo sapiens (Human)	240							
Q8N4M7	reviewed	CJ126_HUMAN	Putative uncharacterized protein C10orf126	C10orf126	Homo sapiens (Human)	172							
Q8N5N4	reviewed	CC022_HUMAN	Uncharacterized protein C3orf22	C3orf22	Homo sapiens (Human)	141							
Q8N616	reviewed	TM148_HUMAN	Putative uncharacterized protein encoded by LINC00311	LINC00311 NCRNA00311 TMEM148	Homo sapiens (Human)	119							
Q8N6K4	reviewed	YP021_HUMAN	Putative uncharacterized protein MGC34800		Homo sapiens (Human)	173							
Q8N6U2	reviewed	CL033_HUMAN	Putative uncharacterized protein encoded by LINC00612	LINC00612 C12orf33	Homo sapiens (Human)	182							
Q8N7H1	reviewed	CL061_HUMAN	Putative uncharacterized protein encoded by LINC01465	LINC01465 C12orf61	Homo sapiens (Human)	131							
Q8N7P7	reviewed	YH007_HUMAN	Uncharacterized protein FLJ40521		Homo sapiens (Human)	452							
Q8N812	reviewed	CL076_HUMAN	Uncharacterized protein C12orf76	C12orf76	Homo sapiens (Human)	135							
Q8N814	reviewed	YG045_HUMAN	Putative uncharacterized protein FLJ40140		Homo sapiens (Human)	137							
Q8N8G6	reviewed	CO054_HUMAN	Putative uncharacterized protein encoded by LINC02915	LINC02915 C15orf54	Homo sapiens (Human)	183							
Q8N8J0	reviewed	PI4P1_HUMAN	Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1	PI4KAP1	Homo sapiens (Human)	262							
Q8N8P6	reviewed	YX004_HUMAN	Putative uncharacterized protein FLJ39060		Homo sapiens (Human)	123							
Q8N8V8	reviewed	TM105_HUMAN	Transmembrane protein 105	TMEM105	Homo sapiens (Human)	129				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Q8N976	reviewed	YG039_HUMAN	Putative uncharacterized protein FLJ38264		Homo sapiens (Human)	141							
Q8N9G6	reviewed	YJ012_HUMAN	Putative UPF0607 protein FLJ37424		Homo sapiens (Human)	341							
Q8N9L7	reviewed	YV006_HUMAN	Putative uncharacterized protein FLJ36925		Homo sapiens (Human)	120							
Q8N9P0	reviewed	YF006_HUMAN	Putative uncharacterized protein FLJ36797		Homo sapiens (Human)	234							
Q8N9P6	reviewed	CI163_HUMAN	Uncharacterized protein C9orf163	C9orf163	Homo sapiens (Human)	203							
Q8N9U9	reviewed	SPOT1_HUMAN	Putative uncharacterized protein SPANXA2-OT1	SPANXA2-OT1 CXorf18	Homo sapiens (Human)	137							
Q8N9X3	reviewed	YA026_HUMAN	Putative uncharacterized protein encoded by LINC01356	LINC01356	Homo sapiens (Human)	169							
Q8NA96	reviewed	YE027_HUMAN	Putative uncharacterized protein FLJ35723		Homo sapiens (Human)	180							
Q8NA97	reviewed	FEAS1_HUMAN	Putative uncharacterized protein FER1L6-AS1 (FER1L6 antisense RNA 1) (FER1L6 antisense gene protein 1)	FER1L6-AS1 C8orf54	Homo sapiens (Human)	138							
Q8NAE3	reviewed	CA180_HUMAN	Putative uncharacterized protein encoded by LINC01555	LINC01555 C1orf180	Homo sapiens (Human)	123							
Q8NAQ8	reviewed	YP023_HUMAN	Putative uncharacterized protein FLJ34945		Homo sapiens (Human)	132							
Q8NBF4	reviewed	YG006_HUMAN	Putative uncharacterized protein FLJ33307		Homo sapiens (Human)	154							
Q8NFD4	reviewed	YI018_HUMAN	Uncharacterized protein FLJ76381		Homo sapiens (Human)	153							
Q8TAT8	reviewed	YK045_HUMAN	Putative uncharacterized protein LOC644613		Homo sapiens (Human)	98							
Q8TB33	reviewed	CX024_HUMAN	Putative uncharacterized protein encoded by LINC01560	LINC01560 CXorf24	Homo sapiens (Human)	94							
Q8TCH9	reviewed	YV004_HUMAN	Putative uncharacterized protein FLJ23865		Homo sapiens (Human)	128							
Q8TEV8	reviewed	SMCR5_HUMAN	Smith-Magenis syndrome chromosomal region candidate gene 5 protein	SMCR5	Homo sapiens (Human)	140							
Q8WU49	reviewed	CG033_HUMAN	Uncharacterized protein C7orf33	C7orf33	Homo sapiens (Human)	177							
Q8WWF1	reviewed	CA054_HUMAN	Uncharacterized protein C1orf54	C1orf54	Homo sapiens (Human)	131				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q8WXQ3	reviewed	CN183_HUMAN	Putative uncharacterized protein encoded by LINC01599	LINC01599 C14orf183	Homo sapiens (Human)	324							
Q8WY50	reviewed	PLAC4_HUMAN	Placenta-specific protein 4	PLAC4 C21orf115 D21S418E PP1416	Homo sapiens (Human)	150							
Q8WZ26	reviewed	YS006_HUMAN	Putative uncharacterized protein PP6455	PP6455	Homo sapiens (Human)	134							
Q8WZ69	reviewed	CK040_HUMAN	Putative uncharacterized protein C11orf40 (Ro/SSA1-related protein)	C11orf40 NOV1	Homo sapiens (Human)	217							
Q8WZA8	reviewed	GC224_HUMAN	Putative gastric cancer-related gene 224 protein (GCRG-224) (GCRG-p224)	GCRG224	Homo sapiens (Human)	35							
Q96BQ5	reviewed	CC127_HUMAN	Coiled-coil domain-containing protein 127	CCDC127	Homo sapiens (Human)	260							
Q96BT1	reviewed	CC049_HUMAN	Putative uncharacterized protein C3orf49	C3orf49	Homo sapiens (Human)	292							
Q96CB5	reviewed	CH044_HUMAN	Putative uncharacterized protein C8orf44	C8orf44	Homo sapiens (Human)	159							
Q96IR3	reviewed	YV007_HUMAN	Putative uncharacterized protein MGC15705		Homo sapiens (Human)	41							
Q96IT6	reviewed	ARAS1_HUMAN	Putative uncharacterized protein ARHGAP5-AS1 (ARHGAP5 antisense RNA 1) (ARHGAP5 antisense gene protein 1)	ARHGAP5-AS1 C14orf128	Homo sapiens (Human)	56							
Q96KT0	reviewed	FAAS1_HUMAN	Uncharacterized protein FAM167A-AS1 (FAM167A antisense RNA 1) (FAM167A antisense gene protein 1)	FAM167A-AS1 C8orf12	Homo sapiens (Human)	104							
Q96KT6	reviewed	CH014_HUMAN	Putative uncharacterized protein encoded by LINC00208	LINC00208 C8orf14 NCRNA00208	Homo sapiens (Human)	92							
Q96KX1	reviewed	CD036_HUMAN	Uncharacterized protein C4orf36	C4orf36	Homo sapiens (Human)	117							
Q96LM1	reviewed	CL037_HUMAN	Putative uncharacterized protein encoded by LINC00615	LINC00615 C12orf37	Homo sapiens (Human)	132							
Q96M15	reviewed	IFAS1_HUMAN	Putative uncharacterized protein IGF2BP2-AS1 (IGF2BP2 antisense RNA 1) (IGF2BP2 antisense gene protein 1)	IGF2BP2-AS1 C3orf65	Homo sapiens (Human)	143							
Q96M42	reviewed	CU129_HUMAN	Putative uncharacterized protein encoded by LINC00479	LINC00479 C21orf129 PRED76	Homo sapiens (Human)	142							
Q96M66	reviewed	YP010_HUMAN	Putative uncharacterized protein FLJ32790		Homo sapiens (Human)	194							
Q96M78	reviewed	FEAS2_HUMAN	Putative uncharacterized protein encoded by FER1L6-AS2 (FER1L6 antisense RNA 2) (FER1L6 antisense gene protein 2)	FER1L6-AS2 C8orf78	Homo sapiens (Human)	137							
Q96M85	reviewed	YV008_HUMAN	Putative uncharacterized protein FLJ32756		Homo sapiens (Human)	177							
Q96MF0	reviewed	YO028_HUMAN	Putative uncharacterized protein LOC100506887		Homo sapiens (Human)	132							
Q96MF4	reviewed	CC140_HUMAN	Coiled-coil domain-containing protein 140	CCDC140	Homo sapiens (Human)	163							
Q96MH7	reviewed	CE034_HUMAN	Uncharacterized protein C5orf34	C5orf34	Homo sapiens (Human)	638							
Q96MT0	reviewed	YJ006_HUMAN	Putative uncharacterized protein FLJ31958		Homo sapiens (Human)	163							
Q96MT4	reviewed	CF195_HUMAN	Uncharacterized protein encoded by LINC01600	LINC01600 C6orf195	Homo sapiens (Human)	127							
Q96N68	reviewed	CR015_HUMAN	Putative uncharacterized protein C18orf15	C18orf15	Homo sapiens (Human)	181				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96NJ1	reviewed	YI001_HUMAN	Uncharacterized protein FLJ30774		Homo sapiens (Human)	140		MISCELLANEOUS: This protein is produced by a bicistronic transcript which also produces the C9orf163 protein from an non-overlapping reading frame.					
Q96PS1	reviewed	FACOS_HUMAN	FANCD2 opposite strand protein (Fanconi anemia group D2 protein opposite strand transcript protein)	FANCD2OS C3orf24 HSD19	Homo sapiens (Human)	177							
Q96PS6	reviewed	GAFA1_HUMAN	Putative uncharacterized protein GAFA-1 (Gene associated with FGF-2 activity protein 1)	GAFA1	Homo sapiens (Human)	74				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q96T59	reviewed	CDRTF_HUMAN	CMT1A duplicated region transcript 15 protein	CDRT15	Homo sapiens (Human)	188							
Q9BRP9	reviewed	YK016_HUMAN	Putative uncharacterized protein MGC13053		Homo sapiens (Human)	147							
Q9BTD1	reviewed	SHAS3_HUMAN	Putative uncharacterized protein SHANK2-AS3	SHANK2-AS3 C11orf76	Homo sapiens (Human)	123							
Q9BTK2	reviewed	YX002_HUMAN	Putative uncharacterized protein LOC642776		Homo sapiens (Human)	45							
Q9BXW3	reviewed	SNH12_HUMAN	Putative uncharacterized protein SNHG12 (Transformation-related gene 11 protein) (TRG-11)	SNHG12 C1orf79 PNAS-123 TRG11	Homo sapiens (Human)	62							
Q9BZ98	reviewed	TTY12_HUMAN	Putative transcript Y 12 protein	TTTY12 TTY12	Homo sapiens (Human)	90							
Q9BZA0	reviewed	TTY10_HUMAN	Putative transcript Y 10 protein	TTTY10 TTY10	Homo sapiens (Human)	68							
Q9BZK8	reviewed	OCR1_HUMAN	Ovarian cancer-related protein 1	OCR1	Homo sapiens (Human)	76							
Q9BZS9	reviewed	YG041_HUMAN	Putative uncharacterized protein PNAS-138	PNAS-138	Homo sapiens (Human)	49							
Q9H0A3	reviewed	T191A_HUMAN	Transmembrane protein 191A	TMEM191A	Homo sapiens (Human)	160				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Q9H1L0	reviewed	MI1HG_HUMAN	Uncharacterized protein MIR1-1HG (MIR1-1 host gene protein)	MIR1-1HG C20orf166	Homo sapiens (Human)	117							
Q9H2U6	reviewed	CO005_HUMAN	Putative uncharacterized protein encoded by LINC00597	LINC00597 C15orf5	Homo sapiens (Human)	94							
Q9H354	reviewed	YJ001_HUMAN	Putative uncharacterized protein PRO1933	PRO1933	Homo sapiens (Human)	126				membrane [GO:0016020]		membrane [GO:0016020]	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Q9H379	reviewed	YI012_HUMAN	Putative uncharacterized protein PRO3102	PRO3102	Homo sapiens (Human)	93							
Q9H521	reviewed	YM006_HUMAN	Putative uncharacterized protein LOC645739		Homo sapiens (Human)	79							
Q9H693	reviewed	CP095_HUMAN	Uncharacterized protein C16orf95	C16orf95	Homo sapiens (Human)	158							
Q9H7T3	reviewed	CJ095_HUMAN	Uncharacterized protein C10orf95	C10orf95	Homo sapiens (Human)	257							
Q9H8Q6	reviewed	HEAS1_HUMAN	Putative uncharacterized protein encoded by HEXA-AS1 (HEXA antisense RNA 1) (HEXA antisense gene protein 1)	HEXA-AS1 C15orf34	Homo sapiens (Human)	139							
Q9H8V8	reviewed	YD018_HUMAN	Putative uncharacterized protein FLJ13197		Homo sapiens (Human)	135							
Q9H8W2	reviewed	CF155_HUMAN	Putative uncharacterized protein encoded by LINC00472	LINC00472 C6orf155	Homo sapiens (Human)	130							
Q9HAA7	reviewed	YG046_HUMAN	Putative uncharacterized protein FLJ11871		Homo sapiens (Human)	133							
Q9HBI5	reviewed	CEP15_HUMAN	Centrosomal protein 15 kDa	CEP15 C3orf14 HT021	Homo sapiens (Human)	128	FUNCTION: May play a role in ciliary assembly. {ECO:0000305}.			cilium [GO:0005929]		cilium [GO:0005929]	SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000305}. Note=Locates at ciliary distal appendages. {ECO:0000305}.
Q9NRI7	reviewed	PPY2_HUMAN	Putative pancreatic polypeptide 2	PPY2P PPY2	Homo sapiens (Human)	21							
Q9NZ38	reviewed	IDAS1_HUMAN	Uncharacterized protein IDI2-AS1 (IDI2 antisense RNA 1) (IDI2 antisense gene protein 1)	IDI2-AS1 C10orf110 HT009	Homo sapiens (Human)	188							
Q9P1C3	reviewed	YN010_HUMAN	Putative uncharacterized protein PRO2829	PRO2829	Homo sapiens (Human)	46				extracellular region [GO:0005576]		extracellular region [GO:0005576]	SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Q9P1D8	reviewed	YP008_HUMAN	Putative uncharacterized protein PRO2289	PRO2289	Homo sapiens (Human)	64							
Q9P1J3	reviewed	DHAS1_HUMAN	Putative uncharacterized protein DHRS4-AS1 (DHRS4 antisense RNA 1) (DHRS4 antisense gene protein 1)	DHRS4-AS1 C14orf167 PRO1488	Homo sapiens (Human)	65							
Q9UF83	reviewed	YM012_HUMAN	Uncharacterized protein DKFZp434B061		Homo sapiens (Human)	564				extracellular space [GO:0005615]		extracellular space [GO:0005615]	
Q9UFV3	reviewed	YO007_HUMAN	Putative uncharacterized protein DKFZp434L187		Homo sapiens (Human)	132							
Q9UHT4	reviewed	YG001_HUMAN	Putative uncharacterized protein PRO1854	PRO1854	Homo sapiens (Human)	67							
Q9UHU1	reviewed	YK039_HUMAN	Putative uncharacterized protein PRO1716	PRO1716	Homo sapiens (Human)	43							
Q9UI25	reviewed	YP002_HUMAN	Putative uncharacterized protein PRO0461	PRO0461	Homo sapiens (Human)	63							
Q9UI54	reviewed	YT001_HUMAN	Putative uncharacterized protein PRO0628	PRO0628	Homo sapiens (Human)	55							
Q9UI72	reviewed	YE014_HUMAN	Putative uncharacterized protein PRO0255	PRO0255	Homo sapiens (Human)	69							
Q9Y3F1	reviewed	TA6P_HUMAN	Putative TAP2-associated 6.5 kDa polypeptide		Homo sapiens (Human)	56	FUNCTION: May be associated with TAP2 isoform activity.						
Q9Y6C7	reviewed	L3R2A_HUMAN	Putative uncharacterized protein encoded by LINC00312 (Loss of heterozygosity 3 chromosomal region 2 gene A protein)	LINC00312 LOH3CR2A NCRNA00312 NAG7	Homo sapiens (Human)	94							
Q9Y6Z2	reviewed	CF123_HUMAN	Uncharacterized protein encoded by LINC01558 (Protein HGC6.2)	LINC01558 C6orf123	Homo sapiens (Human)	57							
X6R8R1	reviewed	ST15B_HUMAN	Synaptotagmin-15B	SYT15B	Homo sapiens (Human)	474